Patent ID: 6521622
Filing Date: 2003-02-18
Classification: A01N,A61K,C07D

Abstract:
A compound of Formula I: wherein:(a) â€ƒrepresents a 5- or 6-membered heterocyclic aromatic ring in which (i) each of X1-X4 is independently O, S, NRâ€², N, CRâ€³ or a bond; (ii) no more than one of X1-X4 is O, S or NRâ€²; (iii) no more than one of X1-X4 is a bond; (iv) when any one of X1-X4 is S, O or NRâ€², one of the adjacent X1-X4 must represent a bond; and (v) at least one of X1-X4 must be O, S, NRâ€² or N; wherein Râ€² is H, C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, hydroxy, acyloxy, C1-C6 alkoxymethyl, CHF2, cyclopropyl or C1-C4 alkoxy; and, Râ€³ is independently H, halogen, cyano, hydroxy, C1-C3 alkyl, C1-C3 haloalkyl, cyclopropyl, C1-C3 alkoxy, C1-C3 haloalkoxy, C1-C3 alkylthio, aryl, C1-C3 NHC(O)alkyl, NHC(O)H, C1-C3 haloalkylthio, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl or nitro wherein adjacent Râ€³ substituents may form a ring or adjacent Râ€² and Râ€³ substituents may form a ring; (b) Z is O, S or NORZ in which RZ is H or C1-C3 alkyl; and (c) A represents â€ƒin which Q1, Q2 are O or S; W is O, CH2, CHR6, or a bond; R1 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, aryl or heteroaryl; R3 is H, R1, OR1, OC(O)OR1 or OC(O)NR1R6; R6 is independently C1-C6 alkyl, C3-C6 cycloalkyl, C2-C5 alkenyl or C2-C5 alkynyl.