Patent ID: 7943750
Filing Date: 2011-05-17
Classification: A61K,A61P,C07H,Y02A

Abstract:
1. A process for the isolation and purification of monosialoganglioside GM1 comprising the steps of: (a) separating GM1 from Fucosyl-GM-1 in a lipidic mixture containing the monosialoganglioside GM1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions; (b) recovering the solute from the eluted solution; (c) diafiltrating an aqueous solution of the recovered solute of step (b); (d) adding a sodium salt and re-diafiltrating the resulting aqueous solution; and (e) collecting GM1 in the form of its sodium salt.