Patent ID: 9139584
Filing Date: 2015-09-22
Classification: A61P,C07C,C07D

Abstract:
1. A method of treating a disease or condition in a human subject which benefits from inhibition of p38 MAP kinase activity, comprising administering, to a subject in need thereof, an effective amount of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein; W is N, wherein N is substituted with hydrogen, C Y is —O(CR R n is 0 or 1; R X R R R R A is a divalent cycloalkylene radical having 5, 6, or 7 ring atoms; said cycloalkylene ring being attached to W and Y, and fused to a phenyl ring or to a monocyclic heteroaryl ring having 5 or 6 ring atoms, said phenyl or heteroaryl ring being optionally substituted by one or two groups R R R wherein R wherein R R R R alternatively, R and/or R R R z wherein said disease or condition is chronic eosinophilic pneumonia, asthma, COPD, adult respiratory distress syndrome, exacerbation of airways hyper-reactivity consequent to other drug therapy or airways disease that is associated with pulmonary hypertension.