Patent ID: 7045625
Filing Date: 2006-05-16
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of the general formula (I) wherein Ar is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, or triazolyl, comprising the steps of; A) reacting a enantiomerically pure compound of the general formula (II)  wherein R  to give compounds of the general formula (IV)  wherein R B) Cleaving the 2-nitrobenzenesulfonyl group of compounds of the general formula (IV) to give compounds of the general formula (V)  wherein R C) Alkylating a compound of general formula (V);  wherein R  or its enantiomer, wherein R B) reducing a compound of the general formula (XIII) using a hydride donating reagent, to give a compound of the general formula (XI)  wherein R C)) methanolysing by acid treatment a compound of the general formula (XI) to give a compound of the general formula (II) to give compounds of the general formula (I), as defined above.