Patent ID: 7396542
Filing Date: 2008-07-08
Classification: A61K

Abstract:
1. A tablet comprising of the following active ingredient and excipients, in weight to weight percentages: a) about 10% to about 12.5% of paroxetine hydrochloride anhydrous; b) about 70% to about 90% of dibasic calcium phosphate anhydrous; c) about 1.5% to about 5% of sodium starch glycolate; d) about 0.5% to about 3% of magnesium stearate; and e) about 2.5% to about 7.5% of one member selected from the group consisting of povidone and co-povidone, wherein the tablet is prepared by wet granulating paroxetine hydrochloride anhydrous in the presence of povidone or copovidone, dibasic calcium phosphate anhydrous and sodium starch glycolate to obtain a granulate, and converting the granulate to the tablet, and with the proviso that the paroxetine hydrochloride remains substantially anhydrous during the wet granulation process.