Patent ID: 6633819
Filing Date: 2003-10-14
Classification: G16B,G16H,Y02A

Abstract:
A method for identifying the affect of a gene knockout on a regulatory pathway comprising the following steps:(i) identification of the shortest regulatory pathway connecting two gene products; (ii) assigning an initial sign value of â€œâˆ’â€  to the knockout gene product; (iii) multiplying the initial sign value of the knockout gene product with the sign value of the adjacent gene product in the pathway, wherein â€œâˆ’â€  stands for inhibition. â€œ+â€  stands for induction or activation, and â€œ0â€  stands for the lack of interaction between two gene products; and (iv) determining the final sign value at the end of the pathway, wherein â€œâˆ’â€  indicates inhibition and â€œ+â€  indicates induction or activation of the pathway.