Patent ID: 6534530
Filing Date: 2003-03-18
Classification: A61K,A61P,C07K,Y02A

Abstract:
A compound of the formula: wherein: Y is â€”N(Ry)â€”, â€”C(Ry)(Ry)â€”, or â€”Oâ€”, where each Ry is independently H or lower alkyl; R1 is selected from optionally substituted benzothiazole and thiazole; R2 and R8 are each independently selected from H, F, and optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; R3 and R9 are each independently selected from H and optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, â€”OR17, â€”SR17, â€”NR17R18, â€”NR19NR17R18, and â€”NR17OR18where R17, R18, and R19 are each independently selected from H, alkyl, cycloalkyl, heterocyeloalkyl, aryl, heteroaryl, and acyl; R4 is a suitable organic moiety selected from hydroxy, alkyl, oxo, cycloalkyl, heteaocycloalkyl, aryl, heteroaryl, acyl, sulfonyl, mercapto, alkylthio, alkoxy, carboxy, amino, alkylamino, dialkylamino, carbamoyl, arylthio and heteroarylthio, wherein sulfonyl is â€”SO2R, where R is selected from hydroxy, halogen, alkyl, acyl, alkylthio, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carboxy, amino, alkylamino, dialkylamino, carbamoyl, aryloxy, heteroaryloxy, arylthio and heteroarylthio; each of R5, R6 and R7 is independently H, F, or lower alkyl; m is 1; p is 1; A1 is CH or N; A2 is selected from C(R10)(R11) and N(R12); A3 is independently selected from C(R10)(R11) and N(R12); where R10, R11 and R12 are each independently H or lower alkyl; A4 is selected from N(R13) and C(R10)(R11); where R10, R11 and R12 are each independently H or lower alkyl, R13 is H, alkyl, aryl, or acyl, and R14 is H, alkyl, or aryl; provided that A1, (A2)m, (A3)p, and A4 together form a pyrrolidinone ring; or a prodrug, pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof.