Patent ID: 8946477
Filing Date: 2015-02-03
Classification: C07C

Abstract:
1. A mixture of lacosamide enantiomers crystallized in a conglomerate Form, wherein said mixture of lacosamide enantiomers comprises a crystalline Form of lacosamide selected from the group consisting of lacosamide crystalline Form III characterized by an XRD pattern comprising peaks (2θ) at 6.5, 8.3, 10.3, 12.9, 15.6, 16.5, 17.5, 19.5, 21.2, 22.5, 24.2, 24.9, 27.0, and 28.5 degrees (±0.2 degrees); lacosamide crystalline Form I characterized by an XRD pattern comprising peaks (2θ) at 8.2, 10.3, 12.9, 15.6, 16.6, 17.6, 19.5, 20.8, 21.0, 21.4, 25.0, 25.3, 26.1, 27.2, 30.7, 31.4, and 36.6 degrees (±0.2 degrees); lacosamide crystalline Form II characterized by an XRD pattern comprising peaks (2θ) at 5.2, 6.6, 8.1, 10.6, 10.9, 12.5, 15.5, 16.1, 16.8, 17.4, 17.8, 20.5, 21.2, 21.5, 22.1, 22.5, 23.1, 23.8, 24.3, 25.7, 27.1, and 27.6 degrees (±0.2 degrees); lacosamide crystalline Form IV characterized by an XRD pattern comprising peaks (2θ) at 9.5, 14.3, 18.6, 20.0, 23.3 and 25.8 degrees (±0.2 degrees); and lacosamide crystalline Form T characterized by an XRD pattern comprising peaks (2θ) at 8.2, 12.9, 16.5, 19.5 and 24.8 degrees (±0.2 degrees); and mixtures of said crystalline Forms, wherein the mixture includes the (R)-enantiomer of lacosamide, and the (R)-enantiomer of lacosamide is present in an amount of at least about 80% by weight.