Patent ID: 6255333
Filing Date: 2001-07-03
Classification: A01N,A61P,C07D,C07F

Abstract:
A compound of formula I, ##STR5##whereinR.sup.1 represents CN, C.sub.1-6 alkoxycarbonyl, NO.sub.2, CHO, C.sub.1-6 alkanoyl, phenyl optionally substituted by one or more halogen, or C.sub.1-6 alkyl optionally substituted by one or more halogen;R.sup.2 represents a group of formula II, III or IV, ##STR6##in whichR.sup.7 represents H, halogen, carbamoyl, cyano, tri(C.sub.1-6 alkyl)silyl, C.sub.1-6 alkyl optionally substituted by one or more halogen, OH or C.sub.1-6 alkoxy, C.sub.1-6 alkoxycarbonyl, phenyl, or a 5- or 6-membered ring heterocycle which is saturated or partially or fully unsaturated and contains up to 4 hetero-atoms independently selected from up to 4 N atoms, up to 2 O atoms and up to 2 S atoms and which is attached to the alkynyl moiety by an available C, S or N atom where the valence allows;and R.sup.8, R.sup.9 and R.sup.10 each independently represent H, halogen, phenyl optionally substituted by one or more halogen, CN or C.sub.1-6 alkyl optionally substituted by one or more halogen; R.sup.3 represents H, C.sub.1-6 alkyl, halogen, NH.sub.2, NH(C.sub.1-6 alkanoyl), NH(C.sub.1-6 alkoxycarbonyl), N(C.sub.1-6 alkoxycarbonyl).sub.2, NH(C.sub.1-6 alkyl), N(C.sub.1-6 alkyl).sub.2, NHCONH(C.sub.1-6 alkyl), N-pyrrolyl, NHCONH phenyl wherein the phenyl ring may be optionally substituted by one or more halogen, N.dbd.CH(phenyl), OH, C.sub.1-6 alkoxy, SH or S(O).sub.n C.sub.1-6 alkyl wherein the alkyl group may be optionally substituted by one or more halogen) where n is 0, 1 or 2; and R.sup.4, R.sup.5 and R.sup.6 each independently represent H, halogen, C.sub.1-6 alkyl optionally substituted by one or more halogen, C.sub.1-6 alkoxy optionally substituted by one or more halogen, S(O).sub.n (C.sub.1-6 alkyl optionally substituted by one or more halogen) where n is 0, 1 or 2, or CH.sub.3 CO, CN CONH.sub.2, CSNH.sub.2, OCF.sub.3, SCF.sub.3 or SF.sub.5 ; with the proviso that when R.sup.4 and R.sup.6 are H, then R.sup.5 is not H;or a pharmaceutically or veterinarily acceptable salt thereof.