Patent ID: 6465434
Filing Date: 2002-10-15
Classification: A61K,C07H,C07K

Abstract:
A method for inhibiting in a warm-blooded animal the spread of malignant cells expressing sialyl Lea or di-sialyl Lea, to secondary sites, comprising:administering to a warm-blooded animal an effective amount of at least one agent that inhibits the binding of malignant cells expressing sialyl Lea or di-sialyl Lea, to endothelial cells expressing a LEC-CAM, wherein said agent is selected from the group consisting of sialyl Lea, a carbohydrate portion of sialyl Lea, di-sialyl Lea, a carbohydrate portion of di-sialyl Lea, and a glycoconjugate that includes a carbohydrate portion of sialyl Lea or di-sialyl Lea or derivative of either that inhibits the binding of sialyl Lea or di-sialyl Lea to a LEC-CAM.