Patent ID: 6479503
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A method of treating obesity in a patient in need thereof comprising administering to such patient an amount effective thereof of a compound of the formula in whichR1 and R2 form a pyridyl ring which is optionally substituted 1 to 3 times by identical or different substituents; R3 and R4, including the double bond connecting them, form a phenyl ring or a 6-membered cycloalkene ring each of which are optionally substituted 1 to 3 times by identical or different substituents; wherein said substituents on the pyridyl, phenyl or cycloalkene ring are selected from the group consisting of halogen, trifluoromethyl, carboxyl, hydroxyl, straight-chain or branched C1-C6 alkoxy, straight-chain or branched C1-C6 alkoxycarbonyl, or an optionally substituted straight-chain or branched C1-C6 alkyl wherein the substituents on the alkyl group are hydroxyl or straight-chain or branched alkoxy having up to 4 carbon atoms, D represents hydrogen, cycloalkyl having 4 to 12 carbon atoms or straight-chain or branched alkyl having up to 12 carbon atoms, E represents the â€”COâ€” or â€”CSâ€” group, L represents a group of the formula â€”NR9 wherein R9 denotes hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or phenyl, R5 represents phenyl which is optionally substituted 1 to 3 times by identical of different substituents selected from the group consisting of nitro, carboxyl, halogen, cyano straight-chain or branched C2-C6 alkenyl, straight-chain or branched C1-C6 alkoxycarbonyl or optionally substituted C1-C6 straight-chain or branched alkyl wherein the substituents on the alkyl are hydroxyl, carboxyl, straight-chain or branched C1-C6 alkoxy, or straight-chain or branched C1-C6 alkoxycarbonyl, or said phenyl ring is further optionally substituted by a group of the formula â€”ORâ€ƒor â€”NR11R12, wherein R10 denotes hydrogen or straight-chain or branched alkyl or alkenyl each having up to 6 carbon atoms, R11 and R12 are identical or different and denote phenyl, hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms or straight-chain or branched acyl having up to 8 carbon atoms, which is optionally substituted by a group of the formula â€”NR13N14, wherein R13 and R14 are identically or different and denote hydrogen or straight-chain or branched acyl having up to 8 carbon atoms, R6 represents hydrogen, carboxyl or straight-chain or branched alkoxycarbonyl having up to 5 carbon atoms, or represents straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or by a group of the formula â€”Oâ€”COâ€”R15, wherein R15 denotes phenyl which is optionally substituted up to 3 times by identical or different halogen or hydroxyl substituents or by straight-chain or branched alkyl having up to 5 carbon atoms, or straight-chain or branched alkyl or alkenyl each having up to 22 carbon atoms, each of which is optionally substituted by a group of the formula â€”OR16, wherein R16 is hydrogen, benzyl, triphenylmethyl or straight-chain or branched acyl having up to 6 carbon atoms, R7 represents hydrogen, or R6 and R7 together represent the group of the formula &boxH;O, or an isomeric form of said compound or a salt thereof.