Patent ID: 7381744
Filing Date: 2008-06-03
Classification: A61K,A61P

Abstract:
1. A method of treating a condition treatable by the inhibition of vacuolar-type (H+)-ATPase, said method comprising administering to a patient in need thereof an amount effective to inhibit vacuolar-type (H+)-ATPase of at least one compound of the formula: wherein R wherein R R the aromatic ring of formula (I) is unsubstituted or substituted with at least one substituent selected from the group consisting of a halogen, a nitro, an amino, a hydroxyl, a thio, an acyl, an alkyl, and a cyano; the saturated alkyl, unsaturated alkyl and aryl substituents defined in any one or more of R Z is a contiguous linker comprising a chain of 7-10 carbon atoms which, together with the five atoms beginning with the carbon of the aromatic ring of formula (I) in meta-relationship with OR or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein the condition is osteoporosis.