Patent ID: 7192752
Filing Date: 2007-03-20
Classification: C12M,G01N

Abstract:
1. A system for monitoring cell-substrate impedance, comprising: a) one or more multiple well cell-substrate impedance monitoring devices, wherein at least two of the multiple wells of said device comprise an electrode array at the bottom of the well, wherein said electrode array is individually addressed, further wherein said device can be used to measure differences in impedance values that relate to cell behavior; b) an impedance analyzer; c) a device station comprising electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and d) a software program that can control said device station and record and analyze data obtained from said impedance analyzer; wherein said electrode array has an approximately uniform electrode resistance distribution across said electrode array so that the electrode resistances between two locations on said array do not differ by more than 30%.