Patent ID: 9040494
Filing Date: 2015-05-26
Classification: A61K,A61P,C12N

Abstract:
1. A method of attenuating expression of Frizzled Related Protein-1 mRNA of a subject, comprising: administering to an eye of the subject a composition comprising an effective amount of interfering RNA and a pharmaceutically acceptable carrier, the interfering RNA comprising: a sense nucleotide strand, an antisense nucleotide strand, and a region of at least near-perfect contiguous complementarity between the sense and antisense strands of at least 19 nucleotides; wherein the sense strand is 19 to 21 nucleotides, and the antisense strand is 19 to 21 nucleotides and hybridizes to a nucleic acid sequence of SEQ ID NO: 98, wherein the thymines are replaced with uracils, wherein the expression of Frizzled Related Protein-1 mRNA is attenuated thereby.