Patent ID: 7405055
Filing Date: 2008-07-29
Classification: A61B,Y10S,Y10T

Abstract:
1. A method of calibrating an analyte monitoring device for use in measuring analyte amount or concentration in a biological system, and said method comprising determining a calibration ratio (CalRatio) value, wherein wherein BG cp is a blood glucose concentration at the calibration point, active cp is an active signal that corresponds to an electrochemical sensor signal at the calibration point, and offset was a constant value; providing two or more ranges of CalRatio values; identifying a range in which said determined CalRatio value falls; employing an algorithm to predict further measurement values, the algorithm selected from one of a first algorithm and a second algorithm, the first algorithm comprising: where in which BG i is the analyte predicted, BG/cp is the blood glucose value at a calibration point, time is the elapsed time, ative is the active signal, signal being the calibrated signal, p i , q i , r i are coefficients, t i is a constant, e indicates an exponential function, d i is a parameter set usable to determine weightings w i , with τ i , β i , γ i , δ i , and ε i are constants, and the second equation comprising: where in which BG i is the analyte predicted, time c is the elapsed time since calibration, active is the active signal, signal is the calibrated signal, BG/cp is the blood glucose value at a calibration point, p i , q i , r i are coefficients, t i is a constant, e indicates an exponential function, d i is a parameter set usable to determine weightings w i , with τ i , β i , γ i , δ i , and ε i are constants, wherein each of said algorithms is optimized for performance in the identified range; and generating further measurement values indicative of amount or concentration of analyte present in the biological system, said generating comprising obtaining a raw signal specifically related to analyte amount or concentration in the biological system and using said algorithm to correlate the raw signal with a measurement value.