Patent ID: 6258943
Filing Date: 2001-07-10
Classification: C07K

Abstract:
A human neurokinin-3 receptor protein comprising the amino acid sequence (SEQ ID NO:1:) which is:Met Ala Thr Leu Pro Ala Ala Glu 1 5 Thr Trp Ile Asp Gly Gly Gly Gly 10 15 Val Gly Ala Asp Ala Val Asn Leu 20 Thr Ala Ser Leu Ala Ala Gly Ala 25 30 Ala Thr Gly Ala Val Glu Thr Gly 35 40 Trp Leu Gln Leu Leu Asp Gln Ala 45 Gly Asn Leu Ser Ser Ser Pro Ser 50 55 Ala Leu Gly Leu Pro Val Ala Ser 60 Pro Ala Pro Ser Gln Pro Trp Ala 65 70 Asn Leu Thr Asn Gln Phe Val Gln 75 80 Pro Ser Trp Arg Ile Ala Leu Trp 85 Ser Leu Ala Tyr Gly Val Val Val 90 95 Ala Val Ala Val Leu Gly Asn Leu 100 Ile Val Ile Trp Ile Ile Leu Ala 105 110 His Lys Arg Met Arg Thr Val Thr 115 120 Asn Tyr Phe Leu Val Asn Leu Ala 125 Phe Ser Asp Ala Ser Met Ala Ala 130 135 Phe Asn Thr Leu Val Asn Phe Ile 140 Tyr Ala Leu His Ser Glu Trp Tyr 145 150 Phe Gly Ala Asn Tyr Cys Arg Phe 155 160 Gln Asn Phe Phe Pro Ile Thr Ala 165 Val Phe Ala Ser Ile Tyr Ser Met 170 175 Thr Ala Ile Ala Val Asp Arg Tyr 180 Met Ala Ile Ile Asp Pro Leu Lys 185 190 Pro Arg Leu Ser Ala Thr Ala Thr 195 200 Lys Ile Val Ile Gly Ser Ile Trp 205 Ile Leu Ala Phe Leu Leu Ala Phe 210 215 Pro Gln Cys Leu Tyr Ser Lys Thr 220 Lys Val Met Pro Gly Arg Thr Leu 225 230 Cys Phe Val Gln Trp Pro Glu Gly 235 240 Pro Lys Gln His Phe Thr Tyr His 245 Ile Ile Val Ile Ile Leu Val Tyr 250 255 Cys Phe Pro Leu Leu Ile Met Gly 260 Ile Thr Tyr Thr Ile Val Gly Ile 265 270 Thr Leu Trp Gly Gly Glu Ile Pro 275 280 Gly Asp Thr Cys Asp Lys Tyr His 285 Glu Gln Leu Lys Ala Lys Arg Lys 290 295 Val Val Lys Met Met Ile Ile Val 300 Val Met Thr Phe Ala Ile Cys Trp 305 310 Leu Pro Tyr His Ile Tyr Phe Ile 315 320 Leu Thr Ala Ile Tyr Gln Gln Leu 325 Asn Arg Trp Lys Tyr Ile Gln Gln 330 335 Val Tyr Leu Ala Ser Phe Trp Leu 340 Ala Met Ser Ser Thr Met Tyr Asn 345 350 Pro Ile Ile Tyr Cys Cys Leu Asn 355 360 Lys Arg Phe Arg Ala Gly Phe Lys 365 Arg Ala Phe Arg Trp Cys Pro Phe 370 375 Ile Lys Val Ser Ser Tyr Asp Glu 380 Leu Glu Leu Lys Thr Thr Arg Phe 385 390 His Pro Asn Arg Gln Ser Ser Met 395 400 Tyr Thr Val Thr Arg Met Glu Ser 405 Met Thr Val Val Phe Asp Pro Asn 410 415 Asp Ala Asp Thr Thr Arg Ser Ser 420 Arg Lys Lys Arg Ala Thr Pro Arg 425 430 Asp Pro Ser Phe Asn Gly Cys Ser 435 440 Arg Arg Asn Ser Lys Ser Ala Ser 445 Ala Thr Ser Ser Phe Ile Ser Ser 450 455 Pro Tyr Thr Ser Val Asp Glu Tyr 460 Ser 465the receptor protein being free of other human receptor proteins.