Patent ID: 6710068
Filing Date: 2004-03-23
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I): or a pharmaceutically acceptable salt thereof, whereina) R1 is hydrogen; acyl; â€”C(&boxH;O)H; â€”C(&boxH;W)H; â€”C(&boxH;O)R2; â€”C(&boxH;W)R2; â€”C(&boxH;O)OH; â€”C(&boxH;W)OH; â€”C(&boxH;O)OR2; â€”C(&boxH;W)OR2; â€”C(&boxH;O)SH; â€”C(&boxH;)W)SH; â€”C(&boxH;O)SR2; â€”C(&boxH;W)SR2; â€”C(&boxH;O)NH2; â€”C(&boxH;W)NH2; â€”C(&boxH;O)NHR2; â€”C(&boxH;W)NHR2; â€”C(&boxH;O)NR2R3; â€”C(&boxH;W)NR2R3; â€”C(&boxH;W)NHâ€”(CH2)p-(amino acid) or â€”(CH2)p-(amino acid); b) R4â€², R5â€², R6â€², R7â€², R2â€³, R3â€³, R4â€³, R5â€³ and R6â€³ are each independently H; halo; â€”NO2; â€”CN; â€”OH; â€”OR2; â€”SH; â€”SR2; â€”NH2; â€”NHR2; â€”NR2R3; â€”NHSO2â€”C1-3alkyl; â€”NR2SO2â€”C1-3alkyl; â€”NHCOâ€”C1-3alkyl; â€”NR2COâ€”C1-3alkyl; optionally substituted or unsubstituted branched or unbranched alkyl, alkenyl or alkynyl; CH3, CF3, vinyl bromide, â€”CR2R2â€”S(O)nâ€”R3, â€”CR2R2NH2, â€”CR2R2NHR2, â€”CR2R2NR2R3 or â€”CR2R2â€”C(&boxH;O)R2; alkacyl; optionally substituted or unsubstituted acyl; â€”C(&boxH;O)H; â€”C(&boxH;W)H; â€”C(&boxH;O)R2; â€”C(&boxH;W)R2; â€”C(&boxH;O)OH; â€”C(&boxH;W)OH; â€”C(&boxH;O)OR2; â€”C(â€”W)OR2; â€”C(&boxH;O)â€”SH; â€”C(&boxH;W)SH; â€”C(&boxH;O)SR2; â€”C(&boxH;W)SR2; â€”C(&boxH;O)NH2; â€”C(&boxH;W)NH2; â€”C(&boxH;O)NHR2; â€”C(&boxH;W)NHR2; â€”C(&boxH;O)NR2R3; â€”C(&boxH;W)â€”NR2R3; â€”C(&boxH;W)NH(CH2)p-(amino acid), a residue of an amino acid or â€”(CH2)p(amino acid); wherein if R5â€² is hydrogen, F, Cl, Br, â€”NO2, â€”CN, â€”OR2, â€”NR2R2, â€”NHSO2â€”C1-3alkyl or â€”NHCOâ€”C1-3alkyl, then at least one of R4â€², R6â€² and R7â€² is not hydrogen or alternatively, wherein at least two of R4â€², R5â€², R6â€², R7â€² are not hydrogen; c) Z is optionally substituted or unsubstituted acyl, â€”C(&boxH;O)NH2; â€”C(&boxH;W)â€”NH2; â€”C(&boxH;O)NHR2; â€”C(&boxH;W)NHR2; â€”C(&boxH;O)NR2R3; â€”C(&boxH;W)NR2R3; â€”C(&boxH;W)NH(CH2)p-(amino acid); a residue of an amino acid, â€”(CH2)p-(amino acid); â€”C(&boxH;O)R3; â€”C(&boxH;O)H; â€”C(&boxH;W)H; â€”C(&boxH;O)R2; â€”C(&boxH;W)R2; â€”C(&boxH;O)OR3; â€”C(&boxH;O)OH; â€”C(&boxH;W)OH; â€”C(&boxH;O)OR2; â€”C(&boxH;W)â€”OR2; â€”C(&boxH;O)â€”SH; â€”C(&boxH;W)SH; â€”C(&boxH;O)SR2; â€”C(&boxH;W)SR2; optionally substituted or unsubstituted branched or unbranched alkyl, alkenyl or alkynyl; CH3, CF3, vinyl bromide, â€”CR2R2â€”S(O)nâ€”R3, â€”CR2R2NH2, â€”CR2R2NHR2, â€”CR2R2NR2R3 or â€”CR2R2â€”C(&boxH;O)R2; â€”CN, or halo; d) Y is O, S or S(O)n; e) each W is independently O, S, â€”NH2, â€”NHR2, â€”NR2R2, â€”Nâ€”CN, â€”Nâ€”NH2, â€”Nâ€”NHR2, â€”Nâ€”NR2R3, â€”Nâ€”OH or â€”Nâ€”OR2; f) each R2 is independently hydrogen or an optionally substituted or unsubstituted branched or unbranched lower alkyl, alkenyl or alkynyl; or CH3, CF3, vinyl bromide, â€”CR2R2â€”S(O)nâ€”R3, â€”CR2R2NH2, â€”CR2R2NHR2, â€”CR2R2NR2R3 or â€”CR2R2â€”C(&boxH;O)R2; (g) each R3 is independently hydrogen; optionally substituted or unsubstituted branched or unbranched alkyl, alkenyl or alkynyl; CH3CF3, vinyl bromide, â€”CR2R2â€”S(O)nâ€”R3, â€”CR2R2NH2, â€”CR2R2NHR2, â€”CR2R2NR2R3 or â€”CR2R2â€”C(&boxH;O)R2); optionally substituted or unsubstituted aryl; optionally substituted or unsubstituted heterocycle; optionally substituted or unsubstituted alkylaryl; optionally substituted or unsubstituted alkylhereterocycle; optionally substituted or unsubstituted aralkyl; or optionally substituted or unsubstituted heterocyclealkyl; h) each n is independently 0, 1 or 2; i) each p is independently 0, 1, 2, 3, 4 or 5; and j) wherein an optionally substituted branched or unbranched alkyl, alkenyl, alkynyl, lower alkyl, lower alkenyl or lower alkynyl; acyl; aryl; heterocycle; alkaryl; alkheterocycle; arylalkyl or alkylheterocycle substitutents is substituted with one or more of halogen â€”OH, â€”OR2, â€”SH, â€”SR2, oxime, hydrazine â€”C(&boxH;O)H, â€”C(&boxH;W)H, â€”C(&boxH;O)R2, â€”C(&boxH;W)R2, â€”C(&boxH;O)OH, â€”C(&boxH;W)OH, â€”C(&boxH;O)OR2, â€”C(&boxH;W)OR2, â€”C(&boxH;O)SH, â€”C(&boxH;W)SH, â€”C(&boxH;O)SR2, â€”C(&boxH;W)SR2, â€”C(&boxH;O)NH2, â€”C(&boxH;W)NH2, â€”C(&boxH;O)â€”NHR2, â€”C(&boxH;W)NHR2, â€”C(&boxH;O)NR2R3, â€”C(&boxH;W)â€”NR2R3, â€”NH2, â€”NHR2, â€”NR2R3, â€”NHSO2â€”C1-3alkyl, â€”NR2SO2â€”C1-3alkyl, â€”NHCOâ€”C1-3alkyl, â€”NR2COâ€”C1-3alkyl, â€”S(O)nâ€”R3, C1-3 alkoxy, C1-3thioether, or an amino acid residue.