Patent ID: 7612063
Filing Date: 2009-11-03
Classification: A61P,C07D

Abstract:
1. A method for treating or ameliorating a cell proliferative disorder, comprising administering to a subject in need thereof an effective amount of a compound of formula 1 or a pharmaceutically acceptable salt or a pharmaceutical composition thereof, wherein: V is H, halo, NR A is H, fluoro, or NR Z is O; U is selected from the group consisting of NR X is OR n is 1-6; R is an optionally substituted 5-14 membered heterocyclic ring containing one or more N, O or S; or R is a C R R or R wherein R W is selected from the group consisting of provided that U is not morpholinyl or 2,4-difluoroaniline when X is F or pyrrolidinyl; A is F; and W is phenylene; wherein said cell proliferative disorder is a cancer selected from colorectal cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, prostate cancer, brain cancer, skin cancer, renal cancer, ovarian cancer, cervical cancer, leukemia, and lymphoma; thereby treating or ameliorating said cell-proliferative disorder.