Patent ID: 6750019
Filing Date: 2004-06-15
Classification: A61K,C12N,Y02P

Abstract:
An antisense oligonucleotide 8 to 50 nucleobases in length targeted to nucleobases 580 through 599 nucleobases or nucleobases 676 through 728 of a coding region, nucleobases 996 through 1205 or nucleobases 1579 through 1598 of a 3â€² untranslated region of a nucleic acid molecule (SEQ ID NO: 3) encoding insulin-like growth factor binding protein 5, nucleobases 11 through 30 or nucleobases 584 through 603 of a nucleic acid molecule (SEQ ID NO: 10) encoding insulin-like growth factor binding protein 5, nucleobases 4214 through 4233 of an intron region or nucleobases 16817 through 16836 of an intron/exon junction region of a nucleic acid molecule (SEQ ID NO: 11) encoding insulin-like growth factor binding protein 5, or nucleobases 197 through 216 of a 3â€² untranslated region of a nucleic acid molecule (SEQ ID NO: 12) encoding insulin-like growth factor binding protein 5, wherein said oligonuclectide specifically hybridizes with one of said regions and inhibits the expression of insulin-like growth factor binding protein 5.