Patent ID: 6455535
Filing Date: 2002-09-24
Classification: C07D

Abstract:
A substituted aminoquinazolinone (thione) derivative represented by the general formula (I), or a salt thereof: wherein R is a hydrogen atom; a hydroxyl group; a formyl group; a (C1-12)alkyl group; a halo(C1-6)alkyl group; a hydroxy (C1-6) alkyl group; a (C2-6) alkenyl group; a (C2-6)alkynyl group; a (C1-6)alkoxy group; a halo(C1-6)alkoxy group; a (C1-6)alkoxy (C1-3)alkyl group; a (C1-6)-alkoxy (C1-3) alkoxy (C1-3) alkyl group; a (C1-6) alkylthio group; a halo(C1-6)alkylthio group; a (C1-6)alkylsulfinyl group; a (C1-6)alkylsulfonyl group; a (C1-6)alkylthio(C1-3)alkyl group; a di(C1-6)alkoxy(C1 3)alkyl group in which the (C1-6)alkoxy groups may be the same or different; an unsubstituted amino(C1-6)alkyl group; a substituted amino(C1-6)alkyl group having one or two substituents which may be the same or different and are selected from the group consisting of (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C2-6)alkenyl groups and (C2-6)alkynyl groups; a cyano(C1-6)alkyl group; a (C1-6)alkylcarbonyl group; a (C1-6)alkoxycarbonyl group; a hydroxycarbonyl-(C1-3) alkyl group; a (C1-6) alkoxycarbonyl (C1-3) alkyl group; an unsubstituted aminocarbonyl group; a substituted aminocarbonyl group having one or two substituents which may be the same or different and are selected from the group consisting of (C1-6)alkyl groups, (C2-6)-alkenyl groups and (C2-6)alkynyl groups; a (C3-6)-cycloalkyl (C1-3)alkyl group; an unsubstituted phenyl(C1-3)alkyl group; a substituted phenyl(C1-3)alkyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups and halo (C1-6) alkylthio groups; an unsubstituted phenylcarbonyl group; a substituted phenylcarbonyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)-alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups and halo(C16)alkylthio groups; an unsubstituted phenylthio group; a substituted phenylthio group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6) alkyl groups, (C1-6)alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups and halo(C1-6)alkylthio groups; an unsubstituted phenylsulfonyl group; a substituted phenylsulfonyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6) alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups and halo (C1-6) alkylthio groups; an unsubstituted phenyl (C1-6)alkylsulfonyl group; a substituted phenyl(C1-6)alkylsulfonyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups and halo(C1-6)alkylthio groups; an unsubstituted phenyloxycarbonyl group; a substituted phenyloxycarbonyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo (C1-6)alkoxy groups, (C1-6)alkylthio groups and halo(C1-6)-alkylthio groups; an unsubstituted phenyloxy(C1-3)alkyl group; a substituted phenyloxy(C1-3)alkyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo (C1-6) alkoxy groups, (C1-6)alkylthio groups and halo(C1-6)alkylthio groups; an unsubstituted phenyl(C2-6)-alkenyl group; a substituted phenyl (C2-6)alkenyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups, halo(C1-6)alkylthio groups and (C1-2)alkylenedioxy groups; an unsubstituted phenyl(C2-6)alkynyl group; a substituted phenyl(C2-6)alkynyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups, (C1-6)alkoxy groups, halo(C1-6)alkoxy groups, (C1-6)alkylthio groups, halo(C1-6)alkylthio groups and (C1-2)alkylenedioxy groups; an unsubstituted phenyl (C2-4)alkynyl (C1-3)alkyl group; a substituted phenyl (C2-4)alkynyl (C1-3)alkyl group having on the ring 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, nitro groups, cyano groups, (C1-6)alkyl groups, halo(C1-6) alkyl groups, (C1-6)alkoxy groups, halo (C1-6) alkoxy groups, (C1-6) alkylthio groups, halo (C1-6)alkylthio groups and (C1-2)alkylenedioxy groups; a 1,3-dioxolan-2-yl(C1-3)alkyl group; or a phthalimido(C1-6)alkyl group,R1 is a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms which may be the same or different and are selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, said heterocyclic ring may have 1 to 5 substituents which may be the same or different and are selected from the group consisting of halogen atoms, cyano groups, (C1-6)alkyl groups, halo(C1-6)alkyl groups and (C1-6)alkoxy groups, and the nitrogen atom in the heterocyclic ring may form an N-oxide group, Y is an oxygen atom or a sulfur atom, Z is â€”N(R3)â€”CH(R2)â€”(wherein R2 is a hydrogen atom, a (C1-6)alkyl group or a halo(C1-6)alkyl group, and R3 is a hydrogen atom, a (C1-6)alkyl group, a formyl group, a (C1-3)-alkylcarbonyl group or a halo(C1-3)alkylcarbonyl group),X may be the same or different, and is a halo(C1-10)alkyl group; and n is an integer of 1 to 4.