Patent ID: 8039436
Filing Date: 2011-10-18
Classification: A61K,C07K,G01N

Abstract:
1. A mutated human HoxB4 polypeptide, said mutated human HoxB4 polypeptide differs from the wild type human HoxB4 polypeptide as set forth in SEQ ID NO: 2 only by a mutation selected from the group consisting of a) a mutation replacing the amino acid residue at position 6, 7, 23 and/or 28 of SEQ ID NO: 2 with an aliphatic nonpolar neutral amino acid residue, b) a deletion of the first 31 to 35 amino acid residues of the sequence set forth in SEQ ID NO: 2, and c) a combination of a) and b), wherein said mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation, and said mutated HoxB4 polypeptide has the activity of enhancing expansion of a hematopoietic stem cell containing population.