Patent ID: 6756355
Filing Date: 2004-06-29
Classification: A01K,A61K,C07K,C12Q,G01N

Abstract:
A method for screening a candidate compound for inhibiting high mobility group protein I (HMGI) biological activity comprising the steps of:(a) immobilizing an HMGI protein, or a fragment thereof, on a solid surface, wherein the fragment includes a biologically active region of the HMGI protein; (b) incubating the HMGI protein, or the fragment thereof, with a candidate compound under conditions which promote optimal interaction; (c) identifying the candidate compound that binds the HMGI protein, or the fragment thereof; and (d) determining whether the candidate compound from step (c) inhibits HMGI biological activity, and identifying the candidate compound that inhibits HMGI biological activity, wherein the biological activity of HMGI is to regulate expression of downstream target gene interferon-&bgr;.