Patent ID: 6177444
Filing Date: 2001-01-23
Classification: A61K,A61P,C07D

Abstract:
A compound selected from a group consisting of compounds of formula IA: ##STR8##wherein:R.sub.1 is hydrogen, lower alkyl, or haloacetyl;R.sub.2, R.sub.3, and R.sub.4 are independently hydrogen, halogen, lower alkyl, phenyl, lower alkenyl, lower alkanoyl, amino, trifluoromethyl, amino lower alkyl, nitro, or cyano;t is 0, 1, 2, or 3;Z is N--(Gr).sub.m (Am).sub.n (Alk).sub.p (Ph).sub.q, or CH--(Gr).sub.m (Am).sub.n (Alk).sub.p (Ph).sub.q, wherein Gr is --SO2--, --COO--, or --CO--,Am is --CH(NH.sub.2)--, naturally occurring alpha amino acid residue, or an amino protected residue thereof,Alk is lower alkylene or lower alkenylene, except that, when q is 0, Alk is hydrogen, lower alkyl or lower alkenyl,Ph is phenyl; phenyl substituted with one or more lower alkyl groups; or phenyl substituted with one or more nitro groups,m is 0 or 1 andn, p, and q are independently 0, 1, or 2,provided that at least two of m, n, p, and q are other than 0, when m is 1 and Gr is --COO--, then p is 0, and when q is 1 and Ph is phenyl p is 0 and provided that when Z is N --(Gr).sub.m (Am).sub.n (Alk).sub.p (Ph).sub.q, --(Gr).sub.m (Am).sub.n (Alk).sub.p (Ph).sub.q is not acetyl or 4-chlorobenzoyl.