Patent ID: 9062111
Filing Date: 2015-06-23
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating prostate cancer in a patient comprising administering a CTLA-4 antibody to the patent according to a dosage escalation regimen, which comprises: (a) administering a first CTLA-4 antibody dosage of about 3 mg/kg and then administering one or more increased dosages of the CTLA-4 antibody to the patient until the dosage results in a complete response in the patient; and (b) when the patient experiences a complete response, administering two additional cycles of the CTLA-4 antibody at the dosage level that resulted in the complete response, wherein a complete response is disappearance of the measurable prostate tumor for greater than or equal to one month, wherein the CTLA-4 antibody comprises a heavy chain variable region that comprises CDR1, CDR2, and CDR3 domains; and a light chain variable region that comprises CDR1, CDR2, and CDR3 domains, wherein the heavy chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO:1; the heavy chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:2; the heavy chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:3; the light chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO:4; the light chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:5; and the light chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:6.