Patent ID: 7476670
Filing Date: 2009-01-13
Classification: A61P,C07D

Abstract:
1. A product of formula (I): in which: Y represents N, O, S, CHR3 or ═CR3, the dashed line on the ring indicating that the corresponding bond is single or double; R and R1, which may be identical or different, represent hydrogen, halogen, hydroxyl, alkyl, alkoxy, cyano, NO n represents an integer of 0 to 2, R3 represents hydrogen, halogen, alkyl, cyano, NO R2 represents a radical alkyl, cycloalkyl, aryl, OR4, SR4 or NR4R5 in which R4 represents a hydrogen atom or an alkyl, cycloalkyl or aryl radical; NR4R5 being such that either R4 and R5, which may be identical or different, are chosen from the values for R4, or R4 and R5 form, together with the nitrogen atom to which they are attached, a heterocyclic radical containing 4 to 6 ring members containing one or more hetero atoms, which may be identical or different, chosen from N, O and S; all the alkyl, alkoxy, cycloalkyl, aryl and heterocyclic radicals defined above being optionally substituted with one or more radicals chosen from halogen atoms, hydroxyl, cyano, trifluoromethyl, trifluoromethoxy, alkoxy, aryl and heterocyclic radicals optionally substituted with a radical with an acid or acid isostere function; and the radicals —NHR4, —NalkR4, —COR4, —COOR4, CONalkR4 and —CONHR4, in which R4 represents a hydrogen atom or an alkyl, cycloalkyl or aryl radical, and alk represents an alkyl radical, all the above phenylalkyl radicals being optionally substituted with one or more radicals chosen from halogen atoms, hydroxyl, cyano, trifluoromethyl, trifluoromethoxy, alkoxy, aryl and heterocyclic radicals optionally substituted with a radical with an acid or acid isostere function; and the radicals —NHR4, —NalkR4, —COR4, —COOR4, —CONalkR4 and —CONHR4, in which R4 represents a hydrogen atom or an alkyl, cycloalkyl or aryl radical, and alk represents an alkyl radical; all the aryl and heterocyclic radicals defined above also being optionally substituted with one or more alkyl, hydroxyalkyl and phenylalkyl radicals; all the aryl radicals defined above also being optionally substituted with a dioxolyl radical; all the alkyl and alkoxy radicals defined above being linear or branched and containing at most 6 carbon atoms; all the cycloalkyl radicals defined above containing at most 6 carbon atoms; wherein the acid or acid isostere function represents a free, salified or esterified carboxyl radical, a free or salified tetrazolyl radical, or a radical selected from the group consisting of —SO3H, —PO(OH)2, NH—SO2-CF3, —NH—SO2-NH—V, NH—SO2-NH—CO—V, NH—CO—V, —NH—CO—NH—V, —NH—CO—NH—SO2-V, —SO2-NH—CO—V, —SO2-NH—CO—NH—V, —CO—NH—V, —CO—NH—OH, —CO—NH—SO2-V; V represents a linear or branched alkyl or alkenyl radical containing at most 6 carbon atoms or a phenyl radical; said alkyl, alkenyl and phenyl radicals represented by V optionally being substituted with one or more radicals chosen from halogen atoms, hydroxyl, cyano, trifluoromethyl, trifluoromethoxy, alkoxy, aryl, heterocyclic, —NHR4, —NalkR4, —COR4, —COOR4, —CONalkR4 and —CONHR4 radicals, in which R4 represents a hydrogen atom or an alkyl, cycloalkyl or aryl radical and alk represents an alkyl; said compounds of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms; or a pharmaceutically acceptable addition salt with an inorganic or organic acid or with an inorganic or organic base of said compound of formula (I).