Patent ID: 6521256
Filing Date: 2003-02-18
Classification: A61K,C07D,Y10S

Abstract:
A method of producing capsules with improved stability which comprises:producing granules by coating a core with a mixture of a basic inorganic salt stabilizing agent, an additive and a benzimidazole compound of the formula 1 wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy hydroxyalkyl, trifluoromethyl, acyl carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl:R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl; R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy; R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy; and m is an integer from 0 to 4 or derivative thereof having an antiulcer activity, followed by further coating with a coating agent and filling the granules in hard capsules.