Patent ID: 8399193
Filing Date: 2013-03-19
Classification: C12Q

Abstract:
1. A method of diagnosing lung cancer comprising: obtaining a lung tissue test sample from a subject; measuring a methylation level of one or a combination of DNA biomarkers selected from the group consisting of NR2E1 (SEQ ID NO. 33), OSR1 (SEQ ID NO. 7) and OTX1 (SEQ ID NO. 10) in the lung tissue test sample; comparing the methylation level of the one or a combination of DNA biomarkers with the methylation level of a corresponding one or combination of DNA biomarkers in a normal lung tissue sample or lung standard sample; and predicting that an increase in the methylation level of the lung tissue test sample in relation to that of the normal lung tissue sample or lung standard sample indicates that the subject is likely to have lung cancer.