Patent ID: 7022490
Filing Date: 2006-04-04
Classification: A61K,C07K

Abstract:
1. A method for identifying specific transcription-modulating substances which comprises the following steps (a) incubating a protein, the protein having the amino acid sequence depicted in SEQ ID NO:2 or being a mutein thereof obtainable by substitution, deletion or insertion of 1 to 100 amino acids and retaining the ability to bind specifically to myc, with the myc gene product under conditions such that a complex between these two proteins is formed, (b) incubating the two proteins in the presence of one or more substances which are to be tested for specific transcription-modulating activities but under conditions which are otherwise the same as in (a), (c) determining the difference in the protein complex formation between (b) and (a), (d) selecting those substances with which the protein complex formation in step (b) is different from that in step (a).