Patent ID: 6410730
Filing Date: 2002-06-25
Classification: C07D

Abstract:
A process for the preparation of a compound of formula I wherein R1 is selected from the group consisting of â€”CO2CH3, â€”CON(CH3)2, â€”OCH2CF3, â€”N(CH3)COCH3, â€”N(CH3)SO2CH3, â€”CF3, and â€”SO2C2H5; R2 is selected from the group consisting of hydrogen and â€”CF3; and M is selected from the group consisting of sodium and potassium; comprising: reacting a compound of formula IV in an aprotic, organic solvent with NH3 to form a compound of formula III which compound III is further reacted in an aprotic, organic solvent with an alkali metal compound selected from the group consisting of a hydride, hydroxide, alcoholate, hydrogen carbonate, and carbonate salt of M to form a compound of formula II wherein M is as defined above; which compound of formula II is further reacted with a compound of formula VI wherein R1 and R2 are as defined above.