Patent ID: 8236806
Filing Date: 2012-08-07
Classification: A61P,C07D

Abstract:
1. A piperazinyl-propyl-pyrazole derivative or its pharmaceutically acceptable salt, wherein said derivative is a compound selected from the group consisting of (1) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperzine; (2) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(2-flourophenyl)piperazine; (3) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (4) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (5) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (6) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (7) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (8) 4-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (9) 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (10) 1-(3-(1-tert-butyl-3-phenyl-1H-pyrazol-5-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (11) 1-phenyl-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (12) 1-(2-fluorophenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (13) 1-(4-chlorophenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (14) 1-(2,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (15) 1-(3,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (16) 1-(2,3-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (17) 1-(4-methoxyphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (18) 2-methyl-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine; (19) 1-(3,4-dichlorophenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (20) 1-(bis(4-fluorophenyl)methyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine; (21) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (22) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (23) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (24) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (25) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (26) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (27) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (28) 4-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (29) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (30) 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (31) 1-phenyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (32) 1-(2-fluorophenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)piperazine; (33) 1-(4-chlorophenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)piperazine; (34) 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (35) 1-(3,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (36) 1-(2,3-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (37) 1-(4-methoxyphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (38) 2-methyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine; (39) 1-(3,4-dichlorophenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (40) 1-(bis(4-fluorophenyl)methyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine; (41) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (42) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (43) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (44) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (45) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (46) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (47) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (48) 4-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (49) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (50) 1-(3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (51) 1-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (52) 1-(2-fluorophenyl)-4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (53) 1-(4-chlorophenyl)-4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (54) 1-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (55) 1-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (56) 1-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (57) 1-(4-methoxyphenyl)-4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (58) 4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (59) 1-(3,4-dichlorophenyl)-4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (60) 1-(bis(4-fluorophenyl)methyl)-4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (61) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (62) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (63) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (64) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (65) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (66) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (67) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,3-methoxyphenyl)piperazine; (68) 4-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (69) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (70) 1-(3-(1-tert-butyl-5-(4-chlorophenyl)-1H-pyrazol-3-yl)propyl)-4-bis(4-fluorophenyl)methyl)piperazine; (71) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (72) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (73) 1-(4-chlorophenyl)-4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (74) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (75) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (76) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (77) 1-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (78) 4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (79) 1-(3,4-dichlorophenyl)-4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (80) 1-(bis(4-fluorophenyl)methyl)-4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (81) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (82) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (83) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (84) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (85) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (86) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (87) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (88) 4-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (89) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (90) 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (91) 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (92) 1-(2-fluorophenyl)-4-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (93) 1-(4-chlorophenyl)-4-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (94) 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (95) 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (96) 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (97) 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (98) 4-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (99) 1-(3,4-dichlorophenyl)-4-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (100) 1-(bis(4-fluorophenyl)methyl)-4-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine; (101) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (102) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (103) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (104) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (105) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (106) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (107) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (108) 4-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (109) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (110) 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (111) 1-phenyl-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (112) 1-(2-fluorophenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (113) 1-(4-chlorophenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (114) 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (115) 1-(3,4-dimethylphenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (116) 1-(2,3-dimethylphenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (117) 1-(4-methoxyphenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (118) 2-methyl-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine; (119) 1-(3,4-dichlorophenyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (120) 1-(bis(4-fluorophenyl)methyl)-4-(3-(1-phenyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)piperazine; (121) 1-phenyl-4-(3-(1-phenyl-3-methyl-1H-pyrazol-5-yl)propyl)piperazine; (122) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-methyl-1H-pyrazol-5-yl)propyl)piperazine; (123) 1-phenyl-4-(3-(1-phenyl-3-ethyl-1H-pyrazol-5-yl)propyl)piperazine; (124) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-ethyl-1H-pyrazol-5-yl)propyl)piperazine; (125) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-phenylpiperazine; (126) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(2-fluorophenyl)piperazine; (127) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(4-chlorophenyl)piperazine; (128) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (129) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (130) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (131) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(4-methoxyphenyl)piperazine; (132) 4-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine; (133) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (134) 1-(3-(1-tert-butyl-5-propyl-1H-pyrazol-3-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (135) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-phenylpiperazine; (136) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2-fluorophenyl)piperazine; (137) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(4-chlorophenyl)piperazine; (138) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2,4-dimethylphenyl)piperazine; (139) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(3,4-dimethylphenyl)piperazine; (140) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2,3-dimethylphenyl)piperazine; (141) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(4-methoxyphenyl)piperazine; (142) 4-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-2-methyl-1-m-tolylpiperazine; (143) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(3,4-dichlorophenyl)piperazine; (144) 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(bis(4-fluorophenyl)methyl)piperazine; (145) 1-phenyl-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (146) 1-(2-fluorophenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (147) 1-(4-chlorophenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (148) 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (149) 1-(3,4-dimethylphenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (150) 1-(2,3-dimethylphenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (151) 1-(4-methoxyphenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (152) 2-methyl-4-(3-(1-phenyl-5-propyl-1-H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine; (153) 1-(3,4-dichlorophenyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (154) 1-(bis(4-fluorophenyl)methyl)-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine; (155) 1-phenyl-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (156) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (157) 1-(4-chlorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (158) 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (159) 1-(3,4-dimethylphenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (160) 1-(2,3-dimethylphenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (161) 1-(4-methoxyphenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (162) 2-methyl-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)-1-m-tolylpiperazine; (163) 1-(3,4-dichlorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (164) 1-(bis(4-fluorophenyl)methyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (165) 1-(2-fluorophenyl)-4-(3-(1-(3-chlorophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (166) 1-(2-fluorophenyl)-4-(3-(1-(4-methoxyphenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (167) 1-(2-fluorophenyl)-4-(3-(1-(4-methylphenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (168) 1-(2-fluorophenyl)-4-(3-(1-(4-fluorophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (169) 1-(2-fluorophenyl)-4-(3-(1-(4-chlorophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine (Compound) (170) 1-(2-fluorophenyl)-4-(3-(1-(4-trifluorophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (171) 1-(2-fluorophenyl)-4-(3-(1-(4-trifluoromethoxyphenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (172) 1-(2-fluorophenyl)-4-(3-(1-(4-nitrophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (173) 1-(2-fluorophenyl)-4-(3-(1-benzyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (174) 1-(2-fluorophenyl)-4-(3-(1-(3-nitrophenyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (175) 1-(2-fluorophenyl)-4-(3-(1-(2′-pyridyl)-3-propyl-1H-pyrazol-5-yl)propyl)piperazine; (176) 1-phenyl-4-(3-(1-phenyl-3-isopropyl-1H-pyrazol-5-yl)propyl)piperazine; (177) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-isopropyl-1H-pyrazol-5-yl)propyl)piperazine; (178) 1-phenyl-4-(3-(1-phenyl-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (179) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (180) 1-(2-fluorophenyl)-4-(3-(1-(3-chlorophenyl-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (181) 1-(2-fluorophenyl)-4-(3-(1-(4-methoxyphenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (182) 1-(2-fluorophenyl)-4-(3-(1-(4-methylphenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (183) 1-(2-fluorophenyl)-4-(3-(1-(4-fluorophenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (184) 1-(2-fluorophenyl)-4-(3-(1-(4-chlorophenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (185) 1-(2-fluorophenyl)-4-(3-(1-(4-trifluoromethylphenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (186) 1-(2-fluorophenyl)-4-(3-(1-(4-nitrophenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (187) 1-(2-fluorophenyl)-4-(3-(1-benzyl-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (188) 1-(2-fluorophenyl)-4-(3-(1-(3-nitrophenyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (189) 1-(2-fluorophenyl)-4-(3-(1-(2′-pyridyl)-3-butyl-1H-pyrazol-5-yl)propyl)piperazine; (190) 1-phenyl-4-(3-(1-phenyl-3-isobutyl-1H-pyrazol-5-yl)propyl)piperazine; and (191) 1-(2-fluorophenyl)-4-(3-(1-phenyl-3-isobutyl-1H-pyrazol-5-yl)propyl)piperazine.