Patent ID: 7803801
Filing Date: 2010-09-28
Classification: A61P,C07D

Abstract:
1. An aminopyridine compound represented by the following formula (I): wherein X (1) —C(R (2) a nitrogen atom; X (1) C(R (2) a nitrogen atom; X (1) —C(R (2) a nitrogen atom; Z represents (1) a nitrogen atom or (2) —C(R Y (1) —CH═ or (2) a nitrogen atom; Y (1) —CH═, or, (2) a nitrogen atom; R (1) a hydrogen atom, (2) a C (3) an acyl group; R (1) a hydrogen atom, (2) a C (3) a halogen atom; R (1) a hydrogen atom, (2) a C (3) a halogen atom; R (1) a hydrogen atom, (2) a halogen atom, (3) —N(R wherein R (4) a hydroxyl group, (5) a C [Group Aa] (a) a hydroxyl group, (b) a C (c) —N(R wherein R (d) —COOR wherein R (e) —CO—N(R wherein R (f) a halogen atom, (6) an aralkoxy group, (7) an acyl group, (8) a saturated heterocyclic group or an aromatic heterocyclic group, wherein the heterocyclic group may be substituted with a C (9) a C [group Ab] (a) a hydroxyl group, (b) —COOR (c) —CO—N(R (d) a halogen atom, (10) —COOR wherein R (11) —CO—N(R (12) a cyano group; R R (1) a hydrogen atom, (2) a C (3) a nitro group; R (1) a hydrogen atom, (2) a C (3) —COOR wherein R (4) a nitro group; R (1) a hydrogen atom, (2) a C (3) —COOR wherein R (4) —N(R wherein R (5) —CO—N(R wherein R (6) an acyl group; R R wherein (1) p represents an integer from 1 to 6, (2) R (3) R [Group Ba] (a) a hydroxyl group, (b) a carboxy group, (c) a C (d) an amino group, (e) a C (f) a di-C (g) an acyloxy group and (h) a halogen atom, (4) R wherein R a hydrogen atom, an acyl group, wherein the acyl group may be substituted with a hydroxyl group or a carboxy group, a C a C a C R R wherein (1) p represents an integer from 1 to 6, (2) R (3) R (a) a hydrogen atom, (b) an aralkyl group, wherein the aralkyl group may be substituted with a hydroxyl group, a C wherein R (c) an aryl group, wherein the aryl group may be substituted with a hydroxyl group, a C (d) a C [Group Ca] a hydroxyl group, an aralkoxy group, —COOR wherein R —N(R an aryl group, wherein the aryl may be substituted with a substituent selected from a hydroxyl group, a C wherein R (4) R (a) a hydrogen atom, (b) a C (c) —COOR wherein R (d) —COR wherein R a C a hydroxyl group, a carboxy group, a C an acyl group, an acyloxy group, an amino group and an acylamino group, a C a 5- or 6-membered aromatic heterocyclic group having 1 to 4 hetero atoms, wherein the heterocyclic group may be substituted with a C an aryl group, wherein the aryl group may be substituted with a hydroxyl group, (e) —CO—N(R (f) —SO R wherein (1) R (a) a hydroxyl group, (b) a C (c) an acyloxy group, and (2) R R wherein R (1) a hydrogen atom, (2) a C (3) a hydroxyl group, (4) a C (5) —N(R wherein R [Group Da] (a) a hydrogen atom, (b) a C (c) a C (d) a C R R wherein Ring A represents a 5- or 6-membered saturated heterocyclic group having 1 or 2 hetero atoms, a 5- or 6-membered aromatic heterocyclic group having 1 to 4 hetero atoms, a 9- to 12-membered condensed aromatic heterocyclic group having 1 or 2 hetero atoms which may be partially saturated a C a C which may be substituted with a substituent respectively selected from the following group Ea: [Group Ea] (a) —OR a hydrogen atom, a C wherein R an acyl group, a carbamoyl group or an aralkyl group, (b) —COOR wherein R (c) —CO—N(R wherein R a hydrogen atom, a C a hydroxyl group, a C a C a C (d) —COR wherein R a hydrogen atom, a C a 5- or 6-membered saturated heterocyclic group or aromatic heterocyclic group having 1 or 2 hetero atoms, wherein the saturated heterocyclic group or aromatic heterocyclic group may be substituted with a hydroxyl group, an oxo group, a carboxy group, a C a C (e) an oxo group, (f) —N(R wherein R a hydrogen atom, a C a C an acyl group, wherein the acyl group may be substituted with a hydroxyl group or a C —CON(R —COR wherein R (g) a C [Group Eb] a hydroxyl group, a C —COOR wherein R —N(R wherein R —CO—N(R wherein R a halogen atom, and a 5- or 6-membered saturated heterocyclic group having 1 or 2 hetero atoms, wherein the saturated heterocyclic group may be substituted with a hydroxyl group or a C (h) —(CH wherein n and m represent an integer of 0 or 1 to 4, and n+m is 1 to 6, R (i) a hydroxyimino group, (j) a C (k) a cyano group, (l) a 5- or 6-membered saturated heterocyclic group (which may be partially unsaturated) containing 1 or 2 hetero atoms selected from a nitrogen atom and an oxygen atom or a 5- or 6-membered aromatic heterocyclic group containing 1 to 4 hetero atoms selected from a nitrogen atom and an oxygen atom, wherein the saturated heterocyclic group and aromatic heterocyclic group may be substituted with an oxo group or a C (m) an aminosulfonyl group and (n) a C R [Group Fa] (a) a C wherein R a hydrogen atom, an acyl group, wherein the acyl group may be substituted with a hydroxyl group or a carboxy group, a C —O—COOR wherein R a C wherein the C a C a carbamoyl group, (b) —COOR wherein R (c) —N(R wherein R (d) —CON(R wherein R (e) —N(R wherein R R (f) an acyl group and (g) a halogen atom; R wherein A represents a linker selected from the following group Ga: [Group Ga] —(CH —(CH —(CH —(CH —(CH —(CO)—, —(CH —(CH —(CH —(CO)NR —(CH wherein k, j and g may be the same or different and represent an integer from 0 to 4 but k and j, or k and g are not 0 at the same time, R a hydrogen atom, a hydroxyl group, a C an acyl group, wherein the acyl group may be substituted with a hydroxyl group or a carboxy group, a C an aralkyl group or a C wherein R an acyl group, wherein the acyl group may be substituted with a hydroxyl group, an aralkyl group, a C a C wherein the C wherein R a hydrogen atom, an acyl group, wherein the acyl group may be substituted with a hydroxyl group, a C wherein the C a C a C a C R Ring B represents a ring selected from the following group Ha: [Group Ha] an aryl group, a C a 5- to 7-membered saturated heterocyclic group containing one or more nitrogen atoms, a 5- or 6-membered aromatic heterocyclic group containing at least one hetero atoms, and an 8- to 11-membered condensed aromatic heterocyclic group containing at least one hetero atoms, and the Ring B may be substituted with a substituent selected from follows group Ia: [Group Ia] (a) —OR wherein R a hydrogen atom, a C an aralkyl group, (b) —COOR wherein R a hydrogen atom, a C an aralkyl group, wherein the alkyl group may be substituted with a hydroxyl group, (c) —N(R wherein R (d) —CO—R a C a C a 5- or 6-membered saturated heterocyclic group containing at least one hetero atoms, wherein the saturated heterocyclic group may be substituted with a hydroxyl group, a C an aryl group, wherein the aryl may be substituted with a hydroxyl group, a 5- or 6-membered aromatic heterocyclic group containing at least one hetero atoms, an aralkyl group or a 5- or 6-membered saturated heterocyclic group containing 1 or 2 hetero atoms, (e) a C wherein R (f) —CO—N(R wherein R (g) a C (h) an oxo group, (i) an aryl group, wherein the aryl group may be substituted with a hydroxyl group, (j) an aralkyl group and (k) a halogen atom; and R wherein R (1) a hydrogen atom, (2) a C wherein R (3) a C (4) a C (5) an aralkyl group, R (1) a C [Group Ja] a hydroxyl group, a C a carboxy group, an aromatic carbocyclic group, wherein the aromatic carbocyclic group may be substituted with a hydroxyl group, a C a C a 5- or 6-membered aromatic heterocyclic group containing 1 or 2 hetero atoms, wherein the aromatic heterocyclic group may be substituted with a carboxy group, a 5- or 6-membered saturated heterocyclic group containing 1 or 2 hetero atoms, —N(R wherein R —CON(R wherein R —COR —COOR (2) an acyl group, wherein the acyl group may be substituted with a hydroxyl group, (3) a C (4) a C (5) a C (6) a 5- or 6-membered saturated heterocyclic group containing 1 or 2 hetero atoms, wherein the saturated heterocyclic group may be substituted with —COR (7) an aromatic carbocyclic group, wherein the aromatic carbocyclic group may be substituted with a carboxy group, a C or a pharmaceutically acceptable salt thereof.