Patent ID: 6906034
Filing Date: 2005-06-14
Classification: A61K,A61P,C07K

Abstract:
1. A method for promoting growth or re-growth of tissue in vivo in an animal or human, said method comprising: administering to said animal or human a therapeutically effective amount of a composition comprising the acid-labile sub-unit (ALS) of insulin-like growth factor binding protein complex, wherein in vivo, the ALS is in complexed form with insulin-like growth factor-I and acid-stable insulin-like growth factor binding protein, whereby growth or regrowth of said tissue is promoted; and wherein said ALS comprises a partial N-terminal amino acid sequence comprising: GlyAspProGlyThrProGlyGluAlaGluGlyProAlaCysProAlaAlaCysAla, wherein the first amino acid may be Gly or Ala (SEQ ID NOs: 1 and 2, respectively, with SEQ ID NO:1 starting with Gly and SEQ ID NO:2 starting with Ala.