Patent ID: 8377895
Filing Date: 2013-02-19
Classification: A61K,A61P,C07D

Abstract:
1. A series of Scutellaria flavonoid organic amine derivatives with the structures illustrated in the following scheme: wherein R 6 is OH and R 8 is N-2′-hydroxyethylpiperazinylmethyl, N-2′-mercapto-ethylpiperazinylmethyl, 4′-hydroxylpiperidinylmethyl, 4′-keto-piperidinylmethyl, 2′-hydroxymethylpyrrolidinylmethyl, 2′-hydroxylpyrrolidinylmethyl or bis(2′-hydroxyethyl)aminomethyl; or wherein R 8 is OCH 3 and R 6 is piperazinylmethyl, N-methylpiperazinylmethyl, N-2′-hydroxyethylpiperazinylmethyl, N-2′-mercapto-ethylpiperazinylmethyl, 4′-hydroxylpiperidinylmethyl, 4′-keto-piperidinylmethyl, 2′-hydroxymethylpyrrolidinylmethyl, 2′-hydroxylpyrrolidinylmethyl, bis(2′-hydroxyethyl)aminomethyl, dimethylaminomethyl, pyrrolidinylmethyl, piperidinylmethyl, N-morpholinomethyl or N-thiomorpholinomethyl