Patent ID: 7091187
Filing Date: 2006-08-15
Classification: A61P,C07H

Abstract:
1. A compound of the formula: wherein M represents a group of Formula II: wherein (i) Z and W independently are >C═O, >CH R R R provided that Z and W cannot both simultaneously be, >C═O, >CH (ii) U and Y independently are hydrogen, halogen, alkyl, or hydroxyalkyl; (iii) R (iv) S wherein R R R S wherein R R R (vi) R (vii) A is hydrogen or methyl; (viii) B is methyl or epoxy; (ix) E hydrogen or halogen; R (xi) R (xii) R (xiii) R wherein M has a linkage site through which it is linked to S via linking group L; provided that linkage site at one or more of the following: a) any reactive hydroxy, nitrogen, or epoxy group located on S b) a reactive >N—R c) a reactive hydroxy group located at any one of R d) any other group that can be first derivatized to a hydroxy or —NR S represents a group of Formula X: wherein R R R R R or a pharmaceutically acceptable salt or solvate thereof; wherein L is a linker molecule to which each of M and S are covalently linked.