Patent ID: 9089490
Filing Date: 2015-07-28
Classification: A61K

Abstract:
1. A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of: rapidly dispersing microgranules comprising a sugar alcohol or a saccharide or a mixture thereof having an average particle size not more than about 30 microns, and a disintegrant, and taste-masked microcapsules containing at least one drug, prepared by granulating a pharmaceutically acceptable formulation comprising the at least one drug in a therapeutically effective amount and at least one polymeric binder imparting resilient characteristics to the resulting microcapsules, wet milling the granulated mass, and coating the milled granules with one or more polymers to provide taste-masked microcapsules, wherein not less than 60% of the at least one drug from said tablet dissolves in about 60 minutes when dissolution tested using USP Apparatus 2 (paddle at 50 RPM, 900 mL of 0.1N HCl at 37° C.).