Patent ID: 8314067
Filing Date: 2012-11-20
Classification: A61K,A61P,C07K,C12N,C12Q

Abstract:
1. A method of treating a condition in a mammal characterized by programmed cell death, said method comprising administering to a cell of said mammal, said cell at increased risk of undergoing programmed cell death, a therapeutically effective amount of a composition which inhibits interleukin 1β-convertase (ICE) comprising (i) a peptide aldehyde having the amino acid sequence tyr-val-X-asp (SEQ ID NO:15), wherein X is selected from the group consisting of ala, his, gln, lys, phe, cha, and asp, or (ii) the cowpox virus CrmA protein, a therapeutically effective amount being an amount which reduces the likelihood that said cell will undergo said programmed cell death.