Patent ID: 6465005
Filing Date: 2002-10-15
Classification: A61F,A61K

Abstract:
A method of preparing a transdermal delivery device comprising the steps of:(a) preparing a mixture of: (i) an active drug component, (ii) a matrix-forming material, and (iii) a measured amount of a steroid hormone, and (b) applying said mixture to a support to form on said support a matrix containing said active drug component, â€ƒsaid step (a) including mixing said measured amount of said steroid hormone with said active drug component and said matrix-forming material, wherein: said active drug component is at least one active hormone drug present in said matrix in an amount having a pharmaceutical or physiological effect when the transdermal delivery device is used; said active hormone drug is present in said matrix at a concentration such that said matrix is one of saturated and supersaturated therewith; said steroid hormone is different from any said active hormone drug present in said matrix; and said steroid hormone being effective to inhibit crystallization of said active drug component during storage of the transdermal delivery device, and said measured amount of said steroid hormone present in said matrix providing no significant pharmaceutical or physiological effect when said device is used.