Patent ID: 6200987
Filing Date: 2001-03-13
Classification: C07C,C07D

Abstract:
A compound of the formula: ##STR11##in which:R.sup.5 is the divalent residue of (i) pyridine, (ii) pyrrolidine, (iii) imidizole, or (iv) thiophene, unsubstituted or substituted with phenyl or phenyl substituted with nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halo, wherein the divalent bonds of said residue are on vicinal ring carbon atoms;R.sup.6 is --CO-- or --SO.sub.2 --;R.sup.7 is (i) straight, branched, or cyclic alkyl of 1 to 12 carbon atoms, (ii) pyridyl, (iii) phenyl substituted with one or more substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, or halo, (iv) benzyl unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halo, (v) naphthyl, (vi) benzyloxy, or (vii) imidazole4-ylmethyl; R.sup.12 is --OH, alkoxy of 1 to 12 carbon atoms, --O--CH.sub.2 -pyridyl, --O---benzyl, or ##STR12##in which:R.sup.8' is hydrogen or alkyl of 1 to 10 carbon atoms; andR.sup.9', is hydrogen, alkyl of 1 to 10 carbon atoms, --CH.sub.2 -pyridyl, benzyl, --COR.sup.10, or--SO.sub.2 R.sup.10 in which R.sup.10 is hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl; andn has a value of 0, 1, 2, or 3.