Patent ID: 7964571
Filing Date: 2011-06-21
Classification: A61K,A61P,B82Y,C12N

Abstract:
1. A combination therapy for the treatment of a solid primary or metastasized tumor in a subject, comprising: administering a pharmaceutical composition to the subject, wherein the administering is intraperitoneal for treatment of tumors originated in or metastasized to the peritoneal cavity, peritumoral, or intratumoral, said pharmaceutical composition comprising a DNA plasmid that encodes interleukin-12 and a lipopolymer, said lipopolymer including a polyethylenimine backbone wherein cholesterol is covalently linked to the polyethylenimine backbone and polyethylene glycol is covalently linked to the polyethylenimine backbone and interleukin-12 is expressed; and administering at least one chemotherapeutic or anticancer agent to the subject, wherein said combination therapy results in inhibition of tumors.