Patent ID: 6645975
Filing Date: 2003-11-11
Classification: A61P,C07D,Y02P

Abstract:
A process for preparing a compound of the formula wherein R1 and R2 each are hydrogen; A is CH2, CHOH or C&boxH;O; R is hydrogen or C1-4alkyl; and R4, R5 and R6 each are independently hydrogen, C1-4alkyl, C1-4alkoxy, hydroxy or halogen, comprising the steps of (a) reducing a compound of the formula wherein R1 and R2 each are a hydroxy-protecting group; or R1 and R2 may be joined together to form â€”(CH2)nâ€” in which n is 1 to 3 and R4, R5 and R6 and A are as defined above; with a reducing agent and (b) deprotecting the resulting reduced product to produce the compound of Formula IX wherein R1 and R2 are hydrogen and (c) optionally, alkylating the product of step (a) or (b) to produce a compound of Formula IX wherein R is C1-4alkyl.