Patent ID: 6537998
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
A compound having the following structure: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein:A is N or CR4; B is N or CR5; Q is a direct bond or â€”(CR8aR8b)râ€”Zâ€”(CR10aR10b)sâ€”; m, r and s are the same or different and selected from 0 to 6; Z is a direct bond or â€”Oâ€”, â€”Sâ€”, â€”NR9â€”, â€”SOâ€”, â€”SO2â€”, â€”OSO2â€”, â€”SO2Oâ€”, â€”SO2NR9â€”, â€”NR9SO2â€”, â€”COâ€”, â€”COOâ€”, â€”OCOâ€”, â€”CONR9â€”, â€”NR9COâ€”, â€”NR9CONR9a, â€”OCONR9â€” or â€”NR9COOâ€”; R1 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, â€”C(R1a)(&boxH;NR1b) or â€”C(NR1aR1c)(&boxH;NR1b); R2 is hydrogen, alkyl or substituted alkyl; or R1 and R2 taken together with the nitrogen atom to which they are attached form heterocycle or substituted heterocycle; R3a and R3b are independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, heterocycle, heterocyclealkyl, hydroxy, alkoxy, alkylthio, alkylamino, CONR14R15 or â€”COOR14; or R3a and R3b taken together with the carbon atom to which they are attached form a 3-6 membered homocycle, substituted homocycle, heterocycle or substituted heterocycle; or R3a and R3b taken together form &boxH;NR3c; R4 is hydrogen, halogen, cyano, nitro, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, heterocyclealkyl, substituted heterocyclealkyl, â€”COR11, â€”COOR11, â€”CONR12R13, â€”OR11, â€”OCOR11, â€”OSO2R11, â€”SR11, â€”SO2R11, â€”NR12R13, â€”NR11COR12, â€”NR11CONR12R13, â€”NR11SO2R12 or â€”NR11SO2NR12R13; R5 is hydrogen, halogen, lower alkyl, arylalkyl, alkoxy, alkylthio, alkylamino, cyano or nitro; R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; R7 is hydrogen, halogen, cyano, alkyl, substituted alkyl, alkoxy, alkylthio, alkylsulfonyl or alkylamino; Ar is aryl, heteroaryl, substituted aryl or substituted heteroaryl; and R1a, R1b, R1c, R3c, R8a, R8b, R9, R9a, R10a, R10b, R11, R12, R13 and R14 are the same or different and at each occurrence independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; or R1a and R1b, R8a and R8b, R10a and R10b, or R12 and R13 taken together with the atom or atoms to which they are attached form homocycle, substituted homocycle, heterocycle or substituted heterocycle.