Patent ID: 6630124
Filing Date: 2003-10-07
Classification: A61K,A61P

Abstract:
A pharmaceutical composition comprising:a) a vasoactive intestinal polypeptide (VIP) antagonist, said VIP antagonist comprising the following amino acid sequence: R1-Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X1-Ala-X2-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-AsnNH-R2 wherein:R1 and R2 are independently members selected from the group consisting of hydrogen, C1 to C20 alkyl and C1 to C20 acyl, provided that at least one of R1 or R2 is hydrogen; and X1 and X2 are independently members selected from the group consisting of naturally occurring amino acids, amino acid analogs, and amino acid mimetics (SEQ ID NO:1); with the proviso that said VIP antagonist does not have the following amino acid sequence: Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (SEQ ID NO:6); b) a chemotherapeutic agent; and c) a pharmaceutically acceptable carrier.