Patent ID: 7173024
Filing Date: 2007-02-06
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula (I) wherein in the formula, the symbol Q is: a straight or branched alkylene chain having 1 to 6 carbon atoms optionally substituted with 1 to 2 substituent(s) each independently being hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl, a phenylene group optionally substituted with 1 to 2 substituent(s) each independently being lower alkyl, hydroxy, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl, or a cycloalkylene group with 5 to 7 carbon atoms optionally substituted with 1 to 2 substituent(s) each independently being lower alkyl, hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl; the symbol A is: a straight or branched alkyl chain having 1 to 3 carbon atoms optionally substituted with COOR wherein R a 5 to 7 membered saturated or unsaturated carbocyclic ring optionally substituted with lower alkyl, COOR a 5 to 7 membered saturated heterocyclic ring optionally substituted with lower alkyl, COOR the symbol G is -aa′-E, wherein E is: a straight or branched alkyl chain having 1 to 5 carbon atoms optionally substituted with COOR wherein R a 5 to 7 membered, saturated or unsaturated, carbocyclic ring optionally substituted with lower alkyl, COOR a 5 to 7 membered, saturated or unsaturated, heterocyclic ring optionally substituted with lower alkyl, COOR the symbols aa and aa′ mean a residue of an α-amino acid, whereby aa can be the same or different from aa′, wherein at least one of aa and aa′ is L-prolyl, and the other of aa and aa′ is L-prolyl, L-alanyl, L-methionyl, L-phenylalanyl, or L-thioprolyl, or a pharmaceutically acceptable salt thereof.