Patent ID: 8501771
Filing Date: 2013-08-06
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein: D is N or C(R1″); R1, R1′, R1″ and R1′″ are R3, R4, R5, R6, R7 and R9 are or R3 and R4, or R5 and R6 R8, R10 and R11 are R12 and R13 are R14 is H, (C x is 0 , 1, 2, 3, 4, 5 or 6; R2 is H, F, Cl, Br, I, OH, CF R15, R16, R17, R18, R19 and R21 are or R15 and R16, or R17 and R18 R20, R22 and R23 are R24 and R25 are R26 is H, (C x′ is 0, 1, 2, 3, 4, 5 or 6; Y is C(R27)(R27′)C(R28)(R28′), or C(R29)=C(R29′); R27, R27′, R28, R28′, R29 and R29′ are X is C(R30)=C(R30′); R30 and R30′ are A is a linker having 2 to 8 members, where the members are selected from the group consisting of O, S, CO, C(R32)(R33), C(R34)=C(R34′), cyclopropylene, resulting in a chemically reasonable radical; R34 and R34′ are R32 and R33 are B is (C R37, R38, R39, R40, R41, R42 and R43 or R38 and R39, or R42 and R43 L is a bond or (C1-C3)-alkylene; Q is N(R53′)(R54′), or a bi-, tri- or spirocyclic saturated or partly unsaturated ring structure having one nitrogen atom and 0-3 additional heteroatoms selected from the group consisting of N, O and S, where the rings of the structure may be spiro-linked, fused or bridged, and where the ring system is optionally substituted one or more times by F, OH, CF R44 is H, (C R45 and R46 are o and p are independently of one another 0, 1, 2, 3, 4, 5 or 6; R47 and R48 are R49, R50, R51, R52, R55 and R56 are or R49 and R50 R53, R54, R53′ and R54′ are or R53 and R54, or R53′ and R54′ o′ is 0, 1, 2, 3, 4, 5 or 6; R58 and R59 are R57, R61, R62, R64, R65, R66, R67, R68, R69, R70 and R71 or R69 and R70 q and r are independently of one another 0, 1, 2, 3, 4, 5 or 6; R60 and R63 are R72, R73, R74, R76, R77 and R78 are or R72 and R73, or R76 and R77 provided that when L is (C or a pharmaceutically acceptable salt thereof.