Patent ID: 9127056
Filing Date: 2015-09-08
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated monoclonal antibody, or an antigen binding fragment thereof, wherein the monoclonal antibody or the antigen binding fragment comprises: a heavy chain variable domain comprising heavy chain complementarity determining regions (H-CDR)1, H-CDR2 and H-CDR3; and a light chain variable domain comprising light chain complementarity determining regions (L-CDR)1, L-CDR2 and L-CDR3, wherein the H-CDR1 comprises amino acids 26 to 33 of the amino acid sequence set forth as SEQ ID NO: 1, the H-CDR2 comprises amino acids 51 to 58 of the amino acid sequence set forth as SEQ ID NO: 1, and-the H-CDR3 comprises amino acids 97 to 109 of the amino acid sequence set forth as SEQ ID NO: 1, wherein the L-CDR1 comprises amino acids 27 to 32 of the amino acid sequence set forth as SEQ ID NO: 2, the L-CDR2 comprises amino acids 50 to 52 of the amino acid sequence set forth as SEQ ID NO: 2, and the L-CDR3 comprises amino acids 89 to 98 of the amino acid sequence set forth as SEQ ID NO: 2, and wherein the monoclonal antibody specifically binds a first epitope of insulin like growth factor (IGF)-II.