Patent ID: 6153744
Filing Date: 2000-11-28
Classification: C07H,Y02P

Abstract:
A nucleoside derivative having a photolabile protective group of the general formula (I): ##STR9## in which R.sup.1 =H, NO.sub.2, CN, OCH.sub.3, halogen or alkyl or alkoxyalkyl having about 1 to about 4 C atomsR.sub.2 =H, OCH.sub.3R.sub.3 =H, F, Cl, Br, NO.sub.2, or an aliphatic acyl radical with about 2 to about 5 C atomsR.sub.4 =H, halogen, OCH.sub.3, an alkyl radical having about 1 to about 4 C atoms or an optionally substituted aryl radicalR.sub.5 =H or a phosphoramidite groupR.sub.6 =H, OH, halogen or XR.sup.8, where X=O, R.sup.8 is selected from alkyl, alkenyl, acetal, and silyl ether protective groups; where X=S, R.sup.8 is an alkyl protective group,B=9-adeninyl, 1-cytosinyl, 9-guaninyl, 1-thyminyl, 1-uracilyl, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5 amino-4-imidazolcarboxamid-1-yl, and 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=9-adeninyl, 1-cytosinyl, or 9-guaninyl, the primary amino function is optionally substituted with a permanent protective group.