Patent ID: 6399788
Filing Date: 2002-06-04
Classification: C07C,C07D

Abstract:
A process for preparing a compound of the formula (I): wherein R is hydrogen or a hydroxy-protecting group; X is hydrogen or alkyl; and double bond represents either E- or Z-configuration, or a pharmaceutically acceptable salt or hydrate thereof, which comprises reacting an amino alcohol of the formula (II): or a salt thereof with a compound of the formula (III): wherein R is hydrogen or a hydroxy-protecting group or a reactive derivative thereof to yield a compound of the formula (I-2): wherein R is as defined above; oxidizing the compound (I-2) with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls to yield a compound of the formula (I-3): wherein R is as defined above; reacting the compound (I-3) with an ylide under the conditions for Wittig reaction and, if desired, deprotecting the reaction product.