Patent ID: 6294531
Filing Date: 2001-09-25
Classification: A61P,C07C,C07D

Abstract:
A compound selected from the group consisting of:(R)-3-[2-cyano-4-[N-benzyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-2-(4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1-dimethyl- 2-(4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-methyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-2-(4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-methyl-N-[methylsulfonyl]amino]phenoxy]-1-[1,1-dimethyl -2-(4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[methylsulfonyl]amino]phenoxy]-1-[1,1-dimethyl -2-(4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-methylsulfonylamino]phenoxy]-1-[1,1-dimethyl-2-(4-metho xyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[methylsulfonyl]amino]phenoxy]-1-[1,1-dimethyl -2-(2-naphthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-[methylsulfonyl]amino]phenoxy]-1-[1,1-dimethyl-2-(2-nap hthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-2-(2-naphthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-2-(benzyloxy)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-3-phenylpropylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-[4-methylphenylsulfonyl]amino]phenoxy]-1-[1,1- dimethyl-4-phenylbutylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N-ethylcarbonyl]phenoxy]-1-[1,1-dimethyl-2-(2-na phthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N'-morpholino]ureido]phenoxy]-1-[1,1-dimethyl-2- (2-naphthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-benzyl-N'-morpholino]ureido]phenoxy]-1-[1,1-dimethyl-2- (4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-methyl-N'-morpholino]ureido]phenoxy]-1-[1,1-dimethyl-2- (2-naphthyl)ethylamino]-propan-2-ol;(R)-3-[2-cyano-4-[N-methyl-N'-morpholino]ureido]phenoxy]-1-[1,1-dimethyl-2- (4-methoxyphenyl)ethylamino]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N,N-diprop ylaminocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N-propylam inocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N-piperidi nylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N-morpholi nylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2,3-dichloro-4-(N-mor pholinylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2,3-dichloro-4-(N-morpholi nylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2,3-dichloro-4-(N,N-d ipropylaminocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2,3-dichloro-4-(N,N-diprop ylaminocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano, 3-chloro-4-(N-morpholinylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano, 3-chloro-4-(N-morpholinylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano, 3-chloro-4-(N,N-dipropylaminocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano, 3-chloro-4-(N,N-dipropylaminocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N-pyrrolid inylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(4-methoxyphenyl)ethylamino]-3-[2-cyano-4-(N-piperazi nylcarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano-4-(N,N-dipropylami nocarbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano-4-(N-piperidinylca rbonyl)phenoxy3-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano-4-(N-morpholinylca rbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano-4-(N-piperazinylca rbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(2-naphthyl)ethylamino]-3-[2-cyano-4-(N-pyrrolidinylc arbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-3-(phenyl)propylamino]-3-[2-cyano-4-(N,N-dipropylaminoc arbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-4-(phenyl)butylamino]-3-[2-cyano-4-(N,N-dipropylaminoca rbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-3-(phenoxy)propylamino]-3-[2-cyano-4-(N,N-dipropylamino carbonyl)phenoxy]-propan-2-ol;(R)-1-[1,1-dimethyl-2-(oxybenzyl)ethylamino]-3-[2-cyano-4-(N,N-dipropylamin ocarbonyl)phenoxy]-propan-2-ol;N-[3-(3-chloro-2-cyano-4-dipropylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4 -methoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-dipropylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(2,3-d ichlorophenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-dimethylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4 -methoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-morpholinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2-(4-me thoxyphenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-morpholinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2-( 4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-pyrrolidinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2- (4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-pyrrolidinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2- (2-naphthyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-morpholinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2-( 2-naphthyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-thiomorpholinosulfamyl)phenoxy-2(R)-hydroxypropyl] -2-(2-naphthyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-thiomorpholinosulfamyl)phenoxy-2(R)-hydroxypropyl] -2-(4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(2'-cyanoeth-1-yl)-cyclopropylsulfamoyl]phenoxy-2( R)-hydroxypropyl]-2-(4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(2'-cyanoeth-1-yl)-cyclopropylsulfamoyl]phenoxy-2( R)-hydroxypropyl]-2-(2-napthyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(benzyl-cyclopropyl)sulfamoyl]phenoxy-2(R)-hydroxy propyl]-2-(2-napthyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(benzyl-cyclopropyl)sulfamoyl]phenoxy-2(R)-hydroxy propyl]-2-(4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(4'-N-t-butoxycarbonylpiperazino)sulfamyl]phenoxy- 2(R)-hydroxypropyl]-2-(4-methoxyphenyl)-1,1-dimethylethylamine;N-[3-[3-chloro-2-cyano-4-(4'-N-t-butoxycarbonylpiperazino)sulfamyl]phenoxy) -2(R)-hydroxypropyl]-2-(2-naphthyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-dipropysulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(2-naph thyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-pyrrolidinolsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4 -methoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-pyperidinolsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4- methoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-cyclopropylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4- methoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-dipropylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4-met hoxyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-propylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4-metho xyphenyl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-sulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4-methoxyphen yl)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-methylsulfamoyl)phenoxy-2(R)-hydroxypropyl]-2-(4-metho xyphenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-pyrrolidinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2- (4-fluorophenyl)-1,1-dimethylethylamine;N-[3-(3-chloro-2-cyano-4-morphoinosulfamyl)phenoxy-2(R)-hydroxypropyl]-2-(b enzyloxy)-1,1-dimethylethylamine;N-[3-(2,3-dichloro-4-morpholinosulfamyl)phenoxy-2(R)-hydroxypropyl]-3-pheny l-1,1-dimethylpropylamine;N-[3-(2,3-dichloro-4-morpholinosulfamyl)phenoxy-2(R)-hydroxypropyl]-4-pheny l-1,1-dimethylbutylamine;or a pharmaceutically acceptable salt thereof.