Patent ID: 6441214
Filing Date: 2002-08-27
Classification: A61P,C07F

Abstract:
A substantially pure thio-analog of phosphonoformic acid comprising the formula: wherein R1 and R2 are each independently selected from alkyl, aryl, H, and cation, R3 is independently selected from alkyl, aryl, H, cation, and a prodrug moiety, and X1, X2, X3, X4, and X5 are each independently selected from O and S, provided that: (a) at least one of X1-X3 is S; (b) when X1 is S, then either (i) R1 or R2 is alkyl, aryl, or H, or (ii) at least one of X2, X3, X4, and X5 is also S; (c) R1 and R2 are different provided that R3 has 1 carbon atom.