Patent ID: 6060080
Filing Date: 2000-05-09
Classification: A61K

Abstract:
An aqueous liposomal dispersion which comprises:(1) an aqueous suspension medium;(2) a water-soluble cationic drug encapsulated in multilamellar liposomes having membranes made of membrane material comprising:(a) an anionic phospholipid comprised of saturated fatty acid residues having 10 to 30 carbon atoms, and(b) cholesterol, and,(c) a neutral phospholipid,wherein the mole ratio of said cholesterol is 30 to 60% of the total amount of all membrane material and the mole ratio of said neutral phospholipid is 0 to 40% of the total amount of all membrane material; and wherein:(1) the total electrolyte concentration of said aqueous suspension medium not including the drug used is not more than 40 mM; and(2) said anionic phospholipid is present in an amount of not less than 2 on an ionic equivalent basis relative to the amount of the drug.