Patent ID: 9192303
Filing Date: 2015-11-24
Classification: A61B

Abstract:
1. An imaging system, comprising: an excitation light source configured to generate excitation light; an optical reporter and an associated nanoparticle or nanocapsule, the optical reporter configured to absorb excitation light and emit an optical signal; a temperature-modulating energy source different from the excitation light source, the temperature-modulating energy source configured to provide temperature-modulating energy to the nanoparticle or nanocapsule, wherein the nanoparticle or nanocapsule is configured to absorb the temperature-modulating energy and generate heat to modulate the temperature of the nanoparticle or nanocapsule associated optical reporter, thereby modulating the intensity and/or lifetime of the optical signal; and a detector configured to detect the optical signal after temperature modulation of the nanoparticle or nanocapsule associated optical reporter.