Patent ID: 6649352
Filing Date: 2003-11-18
Classification: G01N,Y10S

Abstract:
A kit for assessing myclosuppressive state of a patient, comprising a cytokine-specific detection reagent, wherein said cytokines-specific detection reagent comprises antibodies to cytokines selected from the group consisting of fms-like tyrosine-kinase 3 ligand (FLT3-L), tumor necrosis factor-alpha (TNF-&agr;) and transforming growth factor-beta (TGF-&bgr;), and said reagent is adapted to detect a threshold level of at least one said cytoline, said threshold correlating with said state, and instructions for assessing said myelosuppressive state of a patient,wherein said threshold level of FLT3-L is a maximum threshold level, wherein said maximum threshold level is at least about 135 pg/ml of said FLT3-L in plasma; and wherein said threshold level of TGF-&bgr; and TNF-&agr; is a minimum threshold level, wherein said mum threshold level is at most about 0.5 pg/ml of plasma for TNF-&agr;, and about 15 pg/ml of plasma for TGF-&bgr;.