Patent ID: 8796205
Filing Date: 2014-08-05
Classification: A61K,A61P,C07K

Abstract:
1. An insulin derivative having a formula wherein Ins is a parent insulin and X 1 —X 2 —X 3 —Q—Z is a substituent and where the Ins is attached to the substituent via an amide bond between the α-amino group of the N-terminal amino acid residue of the B chain of Ins or an e-amino group of a Lys residue present in the A or B chain of Ins and a CO-group in X 1 , X 2 or X 3 of the substituent; X X X Q is a chain of the formula —(CH and Z is: —COOH; —CO-Asp; —CO-Glu; —CO-Gly; —CO-Sar; —CH(COOH) —N(CH —SO —PO O—SO O—PO tetrazo-5-lyl; and any Zn 2+ complex thereof.