Patent ID: 6492425
Filing Date: 2002-12-10
Classification: A61K,A61P,C07C

Abstract:
A method of inhibiting NF-&kgr;B comprising administering to a patient in need of NF-&kgr;B inhibition an amount effective for inhibiting NF-&kgr;B of a compound of Formula I: wherein:RA substitutes ring A 0-3 times and is independently selected from the group consisting of: NO2, halogen,C1-6alkyl, trifluoromethyl, Oâ€”C1-6alkyl and Sâ€”C1-6alkyl; and RB substitutes ring B 0-3 times and is independently selected from the group consisting of: halogen,C(O)C1-6alkyl, C1-6alkyl, Oâ€”C1-6alkyl, Sâ€”C1-6alkyl, CH2-aryl, and aryl; and pharmaceutically acceptable salts, hydrates and solvates thereof.