Patent ID: 6358514
Filing Date: 2002-03-19
Classification: A61K,A61P,A61Q

Abstract:
A composition, comprising:(a) at least one retinoid selected from the group consisting of vitamin A, retinal and bioconvertible precursors of vitamin A, and (b) at least one histidine compound represented by the formula (I): â€ƒwherein: n is an integer from 0 to 5; nâ€² is an integer from 1 to 16; R represents a side chain of a natural amino acid; X represents â€”COâ€”, â€”Oâ€”COâ€”, â€”NHâ€”COâ€”, â€”SO2â€”, â€”NHâ€”COâ€”COâ€” or â€”Oâ€”COâ€”COâ€”; Râ€² represents a linear or branched, saturated or unsaturated, optionally hydroxylated, C6 to C22 alkyl radical or C6 to C22 aminoalkyl radical, wherein the amine function of the aminoalkyl radical is optionally protected in the form of acetamide or is substituted with one or two lower alkyl groups; with the proviso that Râ€² is an aminoalkyl radical as defined above when X represents â€”COâ€”; and Q+ represents H+ or an organic or inorganic cation; or an addition salt thereof.