Patent ID: 6018058
Filing Date: 2000-01-25
Classification: A61K,C07D

Abstract:
A pharmaceutical composition comprising(a) a safe and effective amount of a DNA cleaving reagent having the formula ##STR22## wherein A is a moiety capable of intercalation between DNA base pairs or groove binding and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each selected from the group consisting of phenyl, substituted phenyl, C.sub.5 -C.sub.20 aryl, C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 substituted alkyl, C.sub.4 -C.sub.8 heterocyclic rings, and polypyrroles; at least one of said R groups being aromatic; and(b) a safe and effective amount of a pharmaceutical carrier.