Patent ID: 6294561
Filing Date: 2001-09-25
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR17##wherein Y is O or NR.sup.4 ;R.sup.1 is selected from the group consisting of lower alkyl, bridged alkyl, aralkyl, cycloalkyl, a 5- or 6-membered saturated heterocycle, C.sub.1-3 alkylenecycloalkyl, aryl- or heteroaryl-substituted propargyl, aryl- or heteroaryl-substlituted allyl, and halocycloalkyl;R.sup.2 is hydrogen, methyl, or halo-substituted methyl;R.sup.3 is selected from the group consisting of C(.dbd.O)OR.sup.7, C(.dbd.O)R.sup.7, C(.dbd.NH)NR.sup.8 R.sup.9, C(.dbd.O)NR.sup.8 R.sup.9, lower alkyl, bridged alkyl, cycloalkyl, haloalkyl, halocycloalkyl, C.sub.1-3 alkylenecycloalkyl, a 5- or 6-membered saturated heterocycle, aryl, heteroaryl, heteroarlySO.sub.2, aralkyl, alkaryl, heteroaralkyl, heteroalkaryl, C.sub.1-3 alkyleneC(.dbd.O)OR.sup.7, C(.dbd.O)C.sub.1-3 alkyleneC(.dbd.O)OR.sup.7, C.sub.1-3 alkyleneheteroaryl, C(.dbd.O)C(.dbd.O)OR.sup.7, C(.dbd.O)C.sub.1-3 alkyleneC(.dbd.O)OR.sup.7, C(.dbd.O)C.sub.1-3 alkyleneNH(C.dbd.O)OR.sup.7, C(.dbd.O)C.sub.1-3 alkyleneNH.sub.2, and NHC(.dbd.O)OR.sup.7 ;R.sup.4 is hydrogen, lower alkyl, haloalkyl, cycloalkyl, aryl, or hereroaryl;R.sup.7 is selected from the group consisting of cycloalkyl, branched or unbranched lower alkyl, heteroaryl, a heterocycle, aralkyl, and aryl, and R.sup.7 can be optionally substituted with one or more of OR.sup.8, NR.sup.8 R.sup.9, or SR.sup.8 ;R.sup.8 and R.sup.9, same or different, are selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, alkaryl, heteroaralkyl, heteroalkaryl, and aralkyl, or R.sup.8 and R.sup.9 together form a 4-membered to 7-membered ring;R.sup.10 is hydrogen, alkyl, haloalkyl, cyclcalkyl, aryl, C(.dbd.O)alkyl, C(.dbd.O)cycloalkyl, C(.dbd.O)aryl, C(.dbd.O)Oalkyl, C(.dbd.O)Ocycloalkyl, C(.dbd.O)aryl, CH.sub.2 OH, CH.sub.2 Oalkyl, CHO, CN, NO.sub.2, or SO.sub.2 R.sup.11 ; andR.sup.11 is alkyl, cycloalkyl, trifluoromethyl, aryl, aralkyl, or NR.sup.8 R.sup.9.