Patent ID: 6489364
Filing Date: 2002-12-03
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula I: â€ƒwherein: Aâ€² and Aâ€³ are independently the same or different group of the formula II: â€ƒwherein: Râ€² is H, CH3, C(CH3)2, â€”ORa, â€”N(Ra)2, â€”N(Ra)ORa or -DP Râ€²â€³ is H or CH3; Ra is H, C1-C3 alkyl; D is a bond, C1-3 alkylene, â€”C(&boxH;O)â€”, â€”S(O)â€” or â€”S(O)2â€”; P is an optionally substituted, mono or bicyclic carbo- or heterocycle; Râ€³ is H, any of the sidechains found in the natural amino acids, carboxacetamido, or a group (CH2)nDP; M is a bond or â€”C(&boxH;O)N(Râ€²â€³)â€”; Q is absent, a bond, â€”CH(OH)â€” or â€”CH2â€”; or Râ€³ together with Q , M and Râ€² define an optionally substituted 5 or 6 membered carbo- or heterocyclic ring which is optionally fused with a further 5 or 6 membered carbo- or heterocyclic ring; with the proviso that Râ€² is â€”ORa, â€”N(Ra)2, â€”N(Ra)ORa or -DP, if M is a bond and Q is absent; X is H, OH, OCH3; Y is H, OH, OCH3, but X and Y are not both H; Zâ€² and Zâ€³ are independently â€”(CH2)mP where P is as defined above; n and m are independently 0, 1 or 2; and pharmaceutically acceptable salts and prodrugs thereof.