Patent ID: 6323202
Filing Date: 2001-11-27
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of formula 1 ##STR38##whereinR.sub.1 is hydroxy or amino;R.sub.2 is hydrogen, halo, (C.sub.1-4)alkyl or (C.sub.1-4)alkoxy;R.sub.3 is halo, amino or azido;R.sub.4 has the same significance as R.sub.2 ;R.sub.5 is hydrogen or (C.sub.1-4)alkyl; andR is (C.sub.1-7)alkyl, (C.sub.3-6)cycloalkyl, {phenyl(C.sub.1-7)alky}, {phenyl(C.sub.1-7)alkoxy}, {{(monocyclic heterocyclo)- {(C.sub.1-7)alkoxy}}, CH(W)C(O){O-(C.sub.1-4)alkyl} wherein W is hydrogen or (C.sub.1-7)alkyl, or ##STR39##wherein Y in hydrogen or (C.sub.1-7)alkyl, and Z is (C.sub.1-7)alkyl, (C.sub.3-6)cycloalkyl, {(C.sub.3-6)cycloalkyl}-{(C.sub.1-7)alkyl}, phenyl(C.sub.1-7)alkyl or {{(monocyclic heterocyclo)-{(C.sub.1-7)alkyl}}, or Y and Z together with the nitrogen atom to which they are attached represent, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 1-(4-methylpiperazinyl);with the provisos that (1) when R is CH(W)C(O)-{O-(C.sub.1-4)alkyl} as defined herein, then R.sub.5 is hydrogen; and (2) at least one of R.sub.2, R.sub.3 and R.sub.4 is other than hydrogen; or a salt thereof.