Patent ID: 8252047
Filing Date: 2012-08-28
Classification: A61F,A61L

Abstract:
1. A method for achieving an effective rate of release of an anti-restenosis drug from a radially expandable stent placed within a vessel at a vascular site of injury, comprising bringing the vessel in contact with the stent having a substantially continuous, substantially polymer-free surface drug coating containing at least about 90 weight percent of an anti-restenosis drug, wherein the surface drug coating is attached to the stent using a liquid-infusible mechanical anchoring layer having an average thickness of at least 3 μm, where the surface drug coating is infused into the anchoring layer, forming a drug coating substratum within the anchoring layer, forming over the drug coating substratum, a substantially continuous surface stratum of drug and, wherein the rate of release of the anti-restenosis drug from the surface drug coating is determined solely by the composition of the surface drug coating, wherein the drug coating substratum constitutes no more than about 25% of said surface drug coating, and the anti-restenosis drug has the structure: where (i) R is H, a linear or branched short-chain alkyl, alkyl alcohol, alkyl ether or aldal group containing no more than ten carbon atoms.