Patent ID: 6107522
Filing Date: 2000-08-22
Classification: C07C

Abstract:
A process for the preparation of cyclopropylamine from butyrolactone, comprising:(a) reacting butyrolactone with hydrogen chloride, thereby yielding chlorobutyric acid;(b) esterifying said chlorobutyric acid with a primary or secondary alcohol having 4-8 carbon atoms;(c) cyclizing the ester with an alkali metal alcoholate of a primary alcohol having 1-3 carbon atoms without addition of an inert solvent to give a mixture of cyclopropanecarboxylic acid esters;(d) converting the cyclopropanecarboxylic acid ester mixture into cyclopropanecarboxylic acid amide by reacting the mixture with ammonia; and(e) reacting said cyclopropanecarboxylic acid amide with hypohalite ion in a basic medium, thereby forming cyclopropylamine.