Patent ID: 6455025
Filing Date: 2002-09-24
Classification: A61K,A61P,C07K

Abstract:
A compound comprising a polysaccharide-somatostatin analog, wherein the somatostatin analog has the formula: wherein said somatostatin analog is directly or indirectly coupled from a terminal N-amino group of the somatostatin analog to a polysaccharide, wherein said amino group has no significant binding activity to somatostatin receptors, and the polysaccharide-somatostatin analog is provided with an effective surface charge by a group of the formula: W1â€”(W2)nâ€”Z wherein the pKa of W1â€”(W2)nâ€”Z is 7 or less and whereinW1 is a group which can form an ether, ester, or amino bond with the polysaccharide; W2 is at least one of C1-6 alkyl or C1-6 arylalkyl, optionally coupled to â€”NH2, â€”SH, or â€”COOH; n is an integer of from 0-7; Z is COOH or SO3H; and wherein said group W1â€”(W2)nâ€”Z provides an effective negative charge to the compound.