Patent ID: 8940928
Filing Date: 2015-01-27
Classification: C07B,C07C,C07F

Abstract:
1. A method of synthesizing levorotatory p-hydroxyphenylglycine compounds, characterized in that, the method comprises the following steps: step 1: the compound of formula II and the compound of formula III undergo nucleophilic addition reaction in a first solvent, to produce the compound of formula IV; wherein the first solvent is selected from the group consisting of ether solvent, ester solvent, haloalkane solvent, C step 2: the compound of formula IV and the compound of formula V undergo a Friedel-Crafts-like reaction in a second solvent, using acid as catalyst, to produce the levorotatory p-hydroxyphenylglycine compound having the structure of formula VI; wherein the second solvent is selected from the group consisting of nitrile solvent, haloalkane solvent, C wherein, R