Patent ID: 8052960
Filing Date: 2011-11-08
Classification: C12Q,G01N

Abstract:
1. A method for aiding detection and assessment of renal dysfunction in a subject, said method comprising: a) quantifying in a blood or urine sample obtained from the subject a netrin-1 polypeptide which comprises an amino acid sequence having at least 95% identity to SEQ ID NO:1 or SEQ ID NO:3 and binds to UNC5B receptor; and b) comparing the level of the netrin-1 polypeptide in the blood or urine sample obtained from the subject with level of the netrin-1 polypeptide in a control sample or with a standard, wherein an increased level of the netrin-1 polypeptide in the urine sample relative to the level of the netrin-1 polypeptide in the control sample or standard is indicative of renal dysfunction; and wherein a decreased level of the netrin-1 polypeptide in the blood sample relative to the level of the netrin-1 polypeptide in the control sample or standard is indicative of renal dysfunction.