Patent ID: 6437135
Filing Date: 2002-08-20
Classification: C07D

Abstract:
A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde of the formula (III): which comprises oxidizing 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline of the formula (I): with a salt of a hypohalogenous acid in the presence of a quaternary ammonium salt of the formula (II): wherein each of R1, R2, R3 and R4, which are each the same or different from each other, is a C1-C16 alkyl or benzyl, which benzyl is optionally substituted by C1-C4 alkyl C1-C4 alkoxy or halogen; and Xâˆ’ is halogen, sulfate or methanesulfonate ion.