Patent ID: 6617457
Filing Date: 2003-09-09
Classification: A61P,C07D

Abstract:
A process for obtaining quinapril hydrochloride of formula (1) which comprises the stages of:a) treatment of the benzyl ester of quinapril (II) where Bz is the benzyl radical, with alcohol and hydrochloric acid or hydrogen chloride and hydrogenation of same through the addition of an appropriate hydrogenation catalyst;b) removal of the solvent used in step a); c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of the toluene solvate of quinapril hydrochloride with a solvent belonging to class 3, capable of forming a solvate of quinapril hydrochloride from which it is possible to eliminate said solvent by drying in an oven without degrading the quinapril hydrochloride; and e) drying of the solvate obtained in step d) at a temperature between 40Â° C. and 50Â° C. to yield quinapril hydrochloride (I).