Patent ID: 6656501
Filing Date: 2003-12-02
Classification: A61K

Abstract:
An oral dosage form for human ingestion configured to be swallowed in whole with a liquid, comprising:a capsule having a first portion and a second portion attached to the first portion, each portion having an interior; an active ingredient concentrated in the interior of the first portion; and a predetermined amount of filler concentrated in the interior of and adhered to the second portion of the capsule, the filler being chosen from the group consisting of sucrose, dextrose, lactose, fructose, microcrystaline cellulose, sorbitol, xylitol, isomalt, gelatin and starch, the filler having a predetermined weight that increases the density of the capsule to a predetermined density that effects sinking of the entire capsule in the liquid, the amount and concentration of the filler being such as to eliminate formation of regions within the interior of the second portion that are relatively low density with respect to the liquid with which the capsule is swallowed; wherein the percentage of the total weight of the capsule that is due to the weight of the filler is between about 15% and 80%; and wherein the amount and concentration of the filler in the interior of the second portion significantly reduce the buoyancy of the capsule so as to cause the entire capsule to sink in the liquid.