Patent ID: 8853178
Filing Date: 2014-10-07
Classification: A61K,A61P,C12N,C12Y,Y02P

Abstract:
1. A chimeric antisense oligonucleotide 20 to 50 nucleobases in length targeted to a nucleic acid molecule encoding PTP1B (SEQ ID NO: 3 or 243), wherein said oligonucleotide comprises the sequence selected from the group consisting of SEQ ID NO: 244, 245, 247, 248, 249, 250, 251, 252, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 267, 268, 269, 271, 275, 276, 277, 278, 279, 281, 282, 283, 288, 290, 291, 292, 294, 296, 297, 298, 299, 300, 302, 303, 307, 310, 311, 313, 317, 318, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 340, 342, 347, 349, 350, 352, 353, 354, 355, 356, 357, 360, 361, 362, 363, 364, 365, 366, 368, 369, 371, 372, 374, 377, 378, 380, 381, and 388 wherein said oligonucleotide specifically hybridizes with said nucleic acid molecule encoding PTP and inhibits the expression of human PTP1B.