Patent ID: 9173840
Filing Date: 2015-11-03
Classification: A61K,A61P

Abstract:
1. A method of making a combinatorial formulation library comprising a plurality of therapeutic agent-loaded polymeric nanoparticulate delivery systems, the method comprising: a) determining the partition coefficient of a therapeutic agent, wherein the therapeutic agent is selected from an siRNA and an anticancer drug; b) solubilizing the therapeutic agent in an aqueous solution; c) combinatorially combining the solubilized therapeutic agent with each of a first plurality of derivatized water-soluble polymers encapsulating the therapeutic agent to form a plurality of nanoparticle cores by self-assembly; d) combinatorially combining each of the plurality of nanoparticle cores with each of a second plurality of derivatized water-soluble polymers to form a plurality of hydrogel-encapsulated nanoparticles by self-assembly; e) combinatorially combining each of the plurality of hydrogel-encapsulated nanoparticles with a plurality of activated PEG derivatives to form a plurality of therapeutic agent-loaded polymeric nanoparticulate delivery systems; wherein each of the therapeutic agent-loaded polymeric nanoparticulate delivery systems differs from one another by at least one of: thereby making a combinatorial formulation library comprising a plurality of therapeutic agent-loaded polymeric nanoparticulate delivery systems.