Patent ID: 8956848
Filing Date: 2015-02-17
Classification: C12N

Abstract:
1. A ubiquitin protease-1 (UBP1) mutant comprising an amino acid sequence having at least one of the following modifications in the UBP1 sequence of SEQ ID NO:5: (a) a proline to leucine substitution at position 415 of the UBP1 sequence; (b) a phenylalanine to leucine substitution at position 739 of the UBP1 sequence; (c) a glutamine to leucine substitution at position 754 of the UBP1 sequence; (d) a fusion of a ubiquitin polypeptide to the N-terminal amino-acid of the UBP1 sequence with a peptide bond; and (e) deletion of at least a portion of the amino acid from positions 1 through 54 of the UBP1 sequence.