Patent ID: 7555337
Filing Date: 2009-06-30
Classification: A61B,A61N

Abstract:
1. A method for non-invasively determining the relative levels of two substances present in a biological system, said method comprising contacting an anodal chamber and a cathodal chamber of an iontophoresis device comprising reversible electrodes with a biological system; extracting by reverse iontophoresis charged and uncharged substances from said biological system, and collecting said charged and uncharged substances each independently into the anodal chamber or the cathodal chamber; determining a first substance and a second substance from said extracted charged and uncharged substances analysing the collected amount of the first substance and the second substance; subsequently, determining the extraction ratio of the first substance to the second substance to determine their relative levels in the biological system; determining at least one of a physiological and pathological condition based on the determined extraction ratio and without requiring blood sampling for calibration.