Patent ID: 6124285
Filing Date: 2000-09-26
Classification: A61P,C07D

Abstract:
A compound represented by the formula (1): ##STR28## wherein R.sup.1 represents hydrogen or lower alkyl;R.sup.3 represents a group of the formula: ##STR29## wherein R.sup.31 and R.sup.33 independently of each other represent hydrogen or lower alkyl, andR.sup.34 represents carboxy, alkoxycarbonyl, cycloalkylalkoxycarbonyl, a group of the formula --CONR.sup.35 R.sup.36, or Het; whereinR.sup.35 and R.sup.36 represent hydrogen, lower alkyl, hydroxyalkyl, phenyl, or a group of the formula --CH.sub.2 --R.sup.37, wherein R.sup.37 represents carboxy or alkoxycarbonyl; orR.sup.35 and R.sup.36 together with the N-atom to which they are attached form a saturated 6-membered heterocyclic ring, optionally containing one additional O atom; andHet represents a saturated or unsaturated 5-membered monocyclic, heterocyclic ring, containing N and/or O as the heteroatom, which ring may optionally be substituted one or more times with substituents selected from the group consisting of halogen, lower alkyl, and oxo;R.sup.5 represents a phenyl group, which may be substituted once with a group of the formula --SO.sub.2 NR.sup.51 R.sup.52 ; wherein R.sup.51 and R.sup.52 each independently represents hydrogen or lower alkyl; orR.sup.51 and R.sup.52 together with the N-atom to which they are attached form a saturated 6-membered monocyclic, heterocyclic ring; andR.sup.6 represents hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof.