Patent ID: 7652139
Filing Date: 2010-01-26
Classification: A61P,C07D

Abstract:
1. Polymorphic Form A of methyl(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H) acetate naphthalene-1,5-disulfonate 1,4-dioxane made by the process comprising the steps of: a) Combining methyl(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H) acetate and naphthalene-1,5-disulfonic acid in a solution of ethanol followed by addition of heptane; b) Filtering the solution formed in step a) through a 0.2 μm nylon filter into a clean vial; c) Evaporating the solvent under nitrogen; d) Slurrying the gel formed in step c) in a 1,4-dioxane-ethanol (9:1) mixture; e) Covering the slurry of step d) with perforated parafilm and allowing the 1,4-dioxane-ethanol mixture to evaporate; f) Temperature cycling the solids formed in step e) between 25-35° C.; and g) Filtering and drying the solids formed in step f), wherein the Polymorphic Form A of methyl(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H) acetate naphthalene-1,5-disulfonate 1,4-dioxane made by steps a)-g) has an X-ray powder diffraction pattern with peaks at 10.8 (Intensity=50%), 11.7 (Intensity=48%), and 13.0 (Intensity=64.5%) degrees two-theta, an FTIR spectrum with peaks at about 1249, 1452, 1760, 2848, 2955, 3090, and 3490 cm −1 , and a melting point of 165° C.