Patent ID: 6180687
Filing Date: 2001-01-30
Classification: A61K,C08F,C09K,Y10S

Abstract:
A method of repairing torn or detached retinal tissue comprising administering to the site in need of repair the ophthalmic composition comprising an ophthalmically acceptable vehicle and a biocompatible, in vivo polymerizable monomer of the structure ##STR6##wherein n is 2-20;w is 1-20;q is 1, 1;Y is H, F;T is --CH.dbd.CH--, --CH.sub.2 --C(.dbd.CH.sub.2)--;R is OH, O.sup.- M.sup.+, OCH.sub.3, NH(CH.sub.2).sub.n N(CH.sub.3).sub.3.sup.+ X.sup.-, (OCH.sub.2 CH.sub.2).sub.w N(CH.sub.3).sub.3.sup.+ X.sup.-, OCH.sub.2 C(CH.sub.2 OH).sub.3, ##STR7##R' is H, CH.sub.3' CH.sub.2 CO.sub.2 H, CH.sub.2 COO.sup.- M.sup.+ ;m is 1-100;M.sup.+ is a pharmaceutically acceptable cation; andX.sup.- is a pharmaceutically acceptable anion,and then polymerizing the composition in vivo using a photoinitiator selected from the group consisting of UV photoinitiators and blue-light photoinitiators.