Patent ID: 6177103
Filing Date: 2001-01-23
Classification: A61K,B01F,B01J,Y10S

Abstract:
A process of preparing a stable suspension of sub-micron particles of a water-insoluble or substantially water-insoluble biologically active compound of up to 2000 nm in size comprising the successive steps of:(a) dissolving a water-insoluble or substantially water-insoluble biologically active compound and a first surface modifier in a liquefied compressed gas solvent therefor and forming a solution of greater than 1% w/w of said compound in said solvent and thereafter;(b) expanding the compressed fluid solution prepared in step (a) into water or aqueous solution containing a second surface modifier and water-soluble agents thereby producing a suspension of microparticles, and thereafter(c) homogenizing the suspension of step (b) at high pressure.