Patent ID: 8975265
Filing Date: 2015-03-10
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A compound of formula (I) in which R1 is hydrogen, hydroxy, halogen, cyano, CO-(1-6C-alkyl), C(O)OR10, CO(NR8R9), NR8R9, NH—C(O)NR8R9, NH—C(O)R11, 2-6C-alkinyl, or R2 is hydrogen, hydroxy, halogen, cyano, CO-(1-6C-alkyl),C(O)OR10, CO(NR8R9), NR8R9, —NH—C(O)R11, —NH—C(O)NR8R9, —NHS(O) R3 is hydrogen, 1-6C-alkyl, R4 is phenyl optionally substituted by 1-6C-alkyl, halogen, cyano, R5 is hydrogen, halogen, R6 is hydrogen, 1-6C-alkyl, A is N, C(R7), R7 is hydrogen, hydroxy, halogen, cyano, C(O)OR10, CO(NR8R9), 3-7C-cycloalkyl, or X is —CH Y is —CH R8, R9 which can be the same or different, is hydrogen, hydroxy, 3-7C-cycloalkyl or R10 is hydrogen, 1-6C-alkyl, R11 is 1-4C-alkyl (optionally substituted independently with one or more halogen or hydroxyl groups) or 3-7C-cycloalkyl, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.