Patent ID: 6458383
Filing Date: 2002-10-01
Classification: A61K,A61P,Y10S

Abstract:
A delayed release pharmaceutical dosage form for oral adminisitraion of low moleclar weight heparin comprising a semi-solid, substantially nonaqueous composition of:(a) a therapeutically effective amount of low molecular weight heparin; (b) a bile salt or a bile acid that is suspended in the composition (i) in amorphous form, (ii) in milled, micronized, or nanosized form, or both (i) and (ii); (c) at least one hydrophilic surfactant and at least one lipoplilic surfactant; and (d) a means for delaying release of the composition from the dosage form following oral administration, wherein the bile salt or bile acid and the surfactants are selected such that upon mixing the composition with an aqueous mediuim at 100Ã— dilution, an optically clear aqucous dispersion is formed having an absorbance of less than about 0.3 at 400 nm.