Patent ID: 6677364
Filing Date: 2004-01-13
Classification: A61K,A61P

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof wherein A is oxazolyl or isoxazolyl; YA is a bond, lower alkyl, lower alkenyl, lower alkynyl, lower alkyl-aryl-alkynyl, or lower alkyl-aryl-alkyl; YB is a bond or methylene; Ar is aryl where aryl is monosubstituted or disubstituted with a group of formula â€ƒwhere Bâ€”Xâ€”B1 together with the carbon atom to which B and B1 are attached forms a 6-membered ring, where B and B1 independently represent alkylene; and X is oxy; where the 6-membered ring is optionally substituted with 1-3 substituents independently selected from hydroxyl, alkyl, alkoxy, alkenyloxy and alkynyloxy; R5 is selected from hydroxyl, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, carboxyl, aminocarbonyl, alkylaminocarbonyl, alkoxycarbonyl, acyl, and cyano; R8 is oximino optionally substituted with alkyl; and n is 0 or 1; or aryl is optionally monosubstituted with halo, hydroxyl, mercapto, amino, nitro, cyano, carbamoyl, alkyl, alkenyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, haloalkyl, alkoxycarbonyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, alkanoylamino, cyanoalkoxy, carbamoylalkoxy, or alkoxycarbonylalkoxy; R1 is aryl optionally substituted with one or more radicals independently selected from alkyl, haloalkyl, cyano, carboxyl, alkoxycarbonyl, hydroxyl, hydroxyalkyl, haloalkoxy, amino, alkylamino, arylamino, nitro, alkoxyalkyl, alkylsulfinyl, halo, alkoxy and alkylthio; and R2 is alkyl or amino.