Patent ID: 7459565
Filing Date: 2008-12-02
Classification: C07D

Abstract:
1. A regiospecific process for preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile, a compound of formula 1, said process comprising: (a) reacting 4-halomethylbenzonitrile with 4-amino-1,2,4-triazole to give 4-[(4-amino-4H-1,2,4-triazolium-1-yl)methyl]benzonitrile halide, a compound of formula 2, deaminating the compound of formula 2 to 4-[1-(1H-1,2,4-triazol-1-yl)methylene]benzonitrile, a compound of formula 3, (c) reacting the compound of formula 3 with 4-fluorobenzonitrile.