Patent ID: 8633159
Filing Date: 2014-01-21
Classification: A61K,A61M,A61P

Abstract:
1. A method of treating a patient having need of increased bone density comprising administering a hPTH (1-34) or salts thereof transdermally to said patient in an amount effective to increase bone density, comprising the steps of: i) providing a device for pulsatile delivery of hPTH (1-34) comprising a microprojection member comprising a plurality of microprojections adapted to pierce the stratum corneum of the patient; wherein a biocompatible coating is disposed on at least one of said plurality of microprojections of said microprojection member, said coating being formed from a coating formulation comprising hPTH (1-34) or salts thereof, and ii) applying said microprojection member of said device to a skin site of said patient, whereby said plurality of stratum corneum-piercing microprojections pierce the stratum corneum and deliver said hPTH (1-34) or salts thereof to said patient; wherein said transdermal administration of said hPTH (1-34) or salts thereof to said patient is effective to achieve rapid on-set of biological action in said patient and rapid off-set after reaching Cmax, thereby effecting an increase in bone density in said patient.