Patent ID: 8309125
Filing Date: 2012-11-13
Classification: A61K,A61P

Abstract:
1. A method for preparing a sustained release oral tablet comprising: a) forming a controlled release metformin hydrochloride tablet comprising 500 mg to 1000 mg of metformin; b) preparing an immediate release coating solution comprising: wherein the ratio of water to organic solvent is 50:50 to 2:98 and the ratio of binder to pioglitazone hydrochloride is 1:9 to 1:11; c) applying the immediate release coating solution to the controlled release metformin hydrochloride tablet so that when tested in a United States Pharmacopeia (USP) Type 2 apparatus at 75 rpm in 900 ml of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37° C., not less than 75% of the pioglitazone hydrochloride is released from the sustained release tablet in 30 minutes.