Patent ID: 9200285
Filing Date: 2015-12-01
Classification: A61K,A61N,A61P,C12N

Abstract:
1. A method for enhancing radiation sensitivity or chemosensitivity in a human suffering from cancer comprising administering from 300 Co 640 mg anti-clusterin antisense oligonucleotide intravenously to the human in need of treatment for a cancer expressing clusterin, which human also receives radiation therapy or a chemotherapeutic agent, wherein the anti-clusterin antisense oligonucleotide has the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin antisense oligonucleotide has a phosphorothioate backbone throughout, sugar moieties of nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modification, has nucleotides 5-17 which are 2′deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19, thereby enhancing radiation sensitivity or chemosensitivity in the human.