Patent ID: 6426348
Filing Date: 2002-07-30
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: wherein X has the formula R15 is halogen, nitro, lower alkyl sulfonyl, cyano, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, lower alkyl aminosulfonyl, perfluoro lower alkyl, lower alkylthio, hydroxy lower alkyl, alkoxy lower alkyl, lower alkylthio lower alkyl, lower alkylsulfinyl lower alkyl, lower alkylsulfonyl lower alkyl, lower alkylsulfinyl, lower alkanoyl, aroyl, aryl, aryloxy; R16 is hydrogen, halogen, nitro, cyano, lower alkyl, OH, perfluoro lower alkyl, or lower alkylthio; and Y is â€ƒwherein Het is a five or six membered heteroaromatic ring bonded via a carbon atom wherein said ring contains one, two or three heteroatoms selected from the group consisting of N, O and S and R30 and R31 are independently hydrogen, lower alkyl, cycloalkyl, halogen, cyano, perfluoroalkyl, or aryl and at least one of R30 and R31 is adjacent to the point of attachment; p is an integer of from 0 to 1; or pharmaceutically acceptable salts and esters thereof.