Patent ID: 6057315
Filing Date: 2000-05-02
Classification: C07D

Abstract:
A compound of Formula I Wherein:X is O, S or N--R.sub.8 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, phenyl or a heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, all of which rings may be optionally substituted up to 3 times by halogen, OR, N(R).sub.2, N(R')(COR'), CN, CO.sub.2 R' or C(O)N(R').sub.2, CO.sub.2 R, COR, CON(R).sub.2, CON(R"").sub.2, SR, SCO.sub.2 R or SC(O)N(R).sub.2 ;R.sub.4 is H, straight or branched alkyl of from 1-6 carbon atoms, alkenyl or alkynyl of from 2 to 6 atoms, phenyl or a heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, all of which rings may be optionally substituted up to 3 times by halogen, OR, N(R).sub.2, N(R')COR', CN, CO.sub.2 R' or CON(R').sub.2, NO.sub.2, N(R).sub.2, N(R)COR, N(R)COR"", COR, CO.sub.2 R, CON(R).sub.2, CON(R"").sub.2, N(R)CON(R).sub.2, or N(R)CO.sub.2 R;R.sub.5 is 1-6 straight or branched alkyl, a cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, phenyl or heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, all of which rings may be optionally substituted up to 3 times by halogen, OR, N(R).sub.2, N(R')COR', CN, CO.sub.2 R' or CON(R').sub.2, OR, N(R).sub.2, N(R)COR, N(R)COR"", C(O)R, CON(R).sub.2, CON(R"").sub.2, SR or SO.sub.2 R;R.sub.6, R.sub.7 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, COR, COR"", SO.sub.2 N(R).sub.2, C(O)N(R).sub.2 and these may be optionally substituted by any of the groups listed for R.sub.5 ;R is H, straight or branched alkyl of 1-6 carbon atoms, cycloalkyl of from 3-6 carbon atoms, phenyl or heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, all of which may be optionally substituted by halogen, OR', N(R').sub.2, N(R')COR', CN, CO.sub.2 R', CON(R').sub.2 ;R' is H, alkyl of from 1-3 carbon atoms or Ph;R"" is part of a naturally occurring amino acid connected via an amide or acyl bond as determined by the formula;halogen is any one of fluoro, chloro, bromo or iodo;or a pharmaceutically acceptable salt.