Patent ID: 7317100
Filing Date: 2008-01-08
Classification: A61P,C07C,C07D

Abstract:
1. A process for the preparation of an epothilone of formula I, wherein A represents O or NR R R R R R Z is O or a bond; or a pharmaceutically acceptable sale thereof; comprising the steps of: (a) reacting an aldehyde of formula II wherein R wherein R wherein R (b) reacting the aldol of formula IV with a reagent capable to introduce a protecting group which is different or identical to R wherein R (c) reacting the carboxylic acid of formula IV with a reagent capable to remove the protecting group R wherein R (d) macrolactonizing the carboxylic acid of formula IV providing the epothilone of formula I, wherein R (e) reacting the epothilone of formula I with a reagent capable of removing the protecting groups R wherein R (f) optionally reacting the epothilone of formula I into an epothilone of formula I wherein R