Patent ID: 6284222
Filing Date: 2001-09-04
Classification: A61K,Y10T

Abstract:
A method of producing an injectable in vivo formulation of hyperpolarized .sup.3 He, comprising the steps of:introducing a plurality of microbubbles into a chamber;directing a quantity of hyperpolarized .sup.3 He into the chamber with the plurality of microbubbles;directing a quantity of liquid into the chamber after the quantity of hyperpolarized .sup.3 He gas and the microbubbles are located therein such that microbubbles are formed and introduced into the chamber independent of the liquid being directed into the chamber, wherein the liquid has a low solubility for .sup.3 He;increasing the pressure in the container to above one atmosphere; andcontacting the microbubbles and the hyperpolarized .sup.3 He with the liquid thereby producing an injectable formulation of hyperpolarized .sup.3 He microbubbles.