Patent ID: 8334136
Filing Date: 2012-12-18
Classification: A61K,A61P,C12N,G01N,Y02A

Abstract:
1. A method for culturing dermal papilla cells that maintain the ability to induce hair follicles, comprising: maintaining or increasing expression of one or a plurality of genes involved in cell adhesion belonging to GO:7155 in the dermal papilla cells, and sub-culturing those dermal papilla cells in which expression of the gene involved in cell adhesion has been maintained or increased; wherein the gene involved in cell adhesion is selected from the group consisting of HAPLN1 (SEQ ID NO:13), COL8A2 (SEQ ID NO:14), NRCAM (SEQ ID NO: 15), EDIL3 (SEQ ID NO:17), CX3CL1 (SEQ ID NO:18), CDON (SEQ ID NO:19), HMCN1 (SEQ ID NO:20), FRAS1 (SEQ ID NO:22), CDH4 (SEQ ID NO:23), MYBPH (SEQ ID NO:24), CDHR3 (SEQ ID NO:25), SLIT2 (SEQ ID NO:27), FN1 (SEQ ID NO:28), ITGBL1 (SEQ ID NO:30), PVRL3 (SEQ ID NO:31) and NRP2 (SEQ ID NO:26).