Patent ID: 6099856
Filing Date: 2000-08-08
Classification: A61K,A61Q,C07C,C07K

Abstract:
A method for preparing an agent which is transportable across a cellular membrane or a lipid-bilayer and which is bioavailable after crossing said membrane or bilayer, said method comprising(a) providing a biologically active agent which can exist in (i) a native conformational state, (ii) a denatured conformational state, and (iii) an intermediate conformational state, said intermediate conformational state being reversible to said native state and said intermediate conformational state being between said native and denatured states; and(b) exposing said biologically active agent to a complexing perturbant to reversibly transform said biologically active agent to said intermediate state and to form a transportable supramolecular complex,said perturbant having a molecular weight ranging from about 150 to about 600 daltons, and having at least one hydrophilic moiety and at least one hydrophobic moiety,said supramolecular complex comprising said perturbant non-covalently complexed with said biologically active agent, andsaid biologically active agent not forming a microsphere with said perturbant; and(c) preparing a mimetic of said supramolecular complex.