Patent ID: 8980274
Filing Date: 2015-03-17
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
1. A composition comprising: (A) one or more purified polypeptides consisting of SEQ ID NO:22-33; (B) one or more purified polypeptides having at least 95% identity to 15 to 27 contiguous amino acids of SEQ ID NO:22; 15 to 30 contiguous amino acids of SEQ ID NO:23; 15 to 27 contiguous amino acids of SEQ ID NO:24; 15 to 27 contiguous amino acids of SEQ ID NO:25; 15 to 30 contiguous amino acids of SEQ ID NO:26; 15 to 27 contiguous amino acids of SEQ ID NO:27; 15 to 16 contiguous amino acids of SEQ ID NO:28; 15 to 19 contiguous amino acids of SEQ ID NO:29; 15 to 30 contiguous amino acids of SEQ ID NO:30; 15 to 27 contiguous amino acids of SEQ ID NO:31; 15 to 19 contiguous amino acids of SEQ ID NO:32; 15 to 49 contiguous amino acids of SEQ ID NO:33; (C) one or more purified polypeptides comprising SEQ ID NO:22-33, wherein the one or more purified polypeptides are 15 to 75 amino acids in length; (D) a purified polypeptide set forth in SEQ ID NO:33, wherein the X at position 1 is absent or C, the X at position 4 is 14 or Q, the X at position 25 is D or G, and the X at position 36 is E or G; (E) a purified polypeptide comprising amino acids 13-41 of SEQ ID NO: (F) a purified polypeptide comprising amino acids 24-49 of SEQ ID NO:33, wherein the X at position 25 is D or G, the X at position 36 is E or G, and a C is optionally present at the amino terminus (SEQ ID NO:31); (G) a purified polypeptide comprising amino acids 1-27 of SEQ ID NO: 33, wherein the X at position 1 is C or absent, and wherein the X at position 25 is D or G (SEQ ID NO 25); (H) a purified polypeptide comprising amino acids 13-27 of SEQ ID NO:33, wherein the X at position 25 is D or G, and a C is optionally present at the amino terminus (SEQ ID NO:28); (I) a purified polypeptide comprising amino acids 24-41 of SEQ ID NO:33, wherein the X at position 25 is D or G, the X at position 36 is E or G, and a C is optionally present at the amino terminus (SEQ ID NO:32); or (J) combinations of (A)-(l), wherein the purified polypeptides of (A)-(J) are: (i) in a multimeric form; (ii) are linked to a heterologous protein, an indicator reagent, an amino acid spacer, an amino acid linker, a signal sequence, a stop transfer sequence, a transmembrane domain, a protein purification ligand, or a combination thereof; (iii) are linked to a moiety that enhances an immune response; (iv) are linked to a moiety that facilitates polypeptide stability; or (v) are present in a fusion protein.