Patent ID: 6538006
Filing Date: 2003-03-25
Classification: C07D

Abstract:
A compound represented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein:t represents either 0 or 1; R1 represents hydrogen, â€”CH2SO2NH2, â€”CO2CH3, â€”CH2CO2CH3, â€”C(O)NH2, â€”C(O)NHCH3, â€”C(O)N(CH3)2, â€”CH2C(O)NHCH3, â€”CH2C(O)N(CH3)2, alkyl, thioalkyl, thioalkyl and the corresponding sulfoxide and sulfone derivatives thereof, alkenyl, alkynyl, alkoxyalkyl, haloalkyl and cycloalkyl radicals and amino acid side chains selected from the group consisting of asparagine, S-methyl cysteine and the corresponding sulfoxide and sulfone derivatives thereof, glycine, leucine, isoleucine, allo-isoleucine, tert-leucine, alanine, phenylalanine, ornithine, histidine, norleucine, glutamine, valine, threonine, allo-threonine, serine, aspartic acid and beta-cyano alanine side chains; R2 represents alkylthioalkyl, cycloalkylthioalkyl, or arylthioalkyl radicals, which radicals are optionally substituted with a substituent selected from the group consisting of â€”NO2, â€”OR15, â€”SR15, and halogen radicals, wherein R15 represents hydrogen and alkyl radicals; R3 represents hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, and heteroaralkyl radicals; Xâ€² represent O, N and C(R17) where R17 represents hydrogen and alkyl radicals; Yâ€² and Yâ€³ independently represent O, S and NR3; R4 and R5 together with the nitrogen atom to which they are bonded represent a N-heterocycle; R6 represents hydrogen and alkyl radicals; R30, R31 and R32 independently represent radicals as defined for R1, or one of R1 and R30 together with one of R31 and R32 and the carbon atoms to which they are attached form a cycloalkyl radical; and R33 and R34 independently represent radicals as defined for R3, or R33 and R34 together with Xâ€² represent cycloalkyl, aryl, heterocyclyl and heteroaryl radicals, provided that when Xâ€² is O, R34 is absent.