Patent ID: 6129956
Filing Date: 2000-10-10
Classification: A61L

Abstract:
A process of coating a surface of an object with hyaluronic acid or a derivative thereof, which comprises the following steps:reacting hyaluronic acid, or a derivative thereof, with an alkoxy silane coupling agent in an aqueous solution or an organic solvent, in the presence of a condensing or bifunctional agent, to give a solution containing the reaction product of the hyaluronic acid, or the derivative thereof, and the alkoxy silane coupling agent;treating a surface of an object with a plasma;coating the treated surface of said object with the solution containing the reaction product of the hyaluronic acid, or the derivative thereof, and the alkoxy silane coupling agent;removing the solution from the surface of said object, while allowing said reaction product of the hyaluronic acid, or the derivative thereof, and the alkoxy silane coupling agent to react with said surface of the object.