Patent ID: 8178509
Filing Date: 2012-05-15
Classification: A61K,A61P

Abstract:
1. A method to treat an acute inflammatory event in a subject with sickle cell disease consisting essentially of administering to a subject in need thereof an effective amount of an A 2A adenosine receptor agonist, wherein the A 2A adenosine receptor agonist is a compound having formula (I): wherein Z Z is CR each R each R R R R wherein R R R each R X is —CH X is an aromatic ring of the formula: each Z each R wherein any of the alkyl, cycloalkyl, heterocycle, aryl, or heteroaryl, groups of R wherein any (C each R each R alternatively R R i is 1 or 2 m is 0 to 8 and p is 0 to 2; provided that m is at least 1 when Z is NR a pharmaceutically acceptable salt thereof, so as to treat an acute inflammatory event in a subject with sickle cell disease.