Patent ID: 8440420
Filing Date: 2013-05-14
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of assessing risk of a thrombotic event in a patient and facilitating a treatment decision for the patient, the method comprising: assaying in vitro platelet function by assaying platelet reactivity, time-to-thrombin formation (TTF), or time-to-fibrin formation (TFF) in a blood sample in response to an agonist, wherein the blood sample is obtained from a patient undergoing platelet inhibitor therapy and having or suspected of having a vascular disease, and wherein assaying platelet reactivity is by a method other than assaying GP Ith/IIIa receptor expression, said assaying in vitro platelet function providing a test score, wherein the test score is independent of a pre-treatment baseline of platelet reactivity in the patient; identifying the patient as at risk of a thrombotic event when the test score for the patient is greater than a risk threshold score based on a population study; and outputting a report indicating an overall risk assessment based on said identifying to facilitate a treatment decision by a clinician.