Patent ID: 9109221
Filing Date: 2015-08-18
Classification: C12N

Abstract:
1. An aqueous slurry of semi-permeable particles, each semi-permeable particle comprising a water-insoluble, semi-permeable polymer providing a continuous polymeric phase including an external particle surface,each semi-permeable particle further comprising multiple discrete cavities within the continuous polymeric phase, and having disposed within at least some of the multiple discrete cavities: (a) a cavity stabilizing hydrocolloid, and (b) an aqueous solution or suspension of an organic catalytic material, and each semi-permeable particle has a mode particle size of at least 1 μm, wherein each semi-permeable particle is impermeable to the organic catalytic material, and the semi-permeable particle is permeable to molecules having a molar mass that is 1000 Daltons or less, and the organic catalytic material is selected from the group consisting of catalase, peroxidase, superoxide dismutase, carbonic anhydrase, cytochrome P450, alcohol dehydrogenase, aspartate aminotransferase, luciferase, hydrolase, glucose oxidase, glucose isomerase, trypsin, papain, protease, lipase, esterase, urease, cellulase, amylase, lactase, phytase, amidase, thermolysin, diacetyl reductase, and nitrile hydrolase, wherein each semi-permeable particle further comprises an amphiphilic block copolymer that is disposed at the interface of the multiple discrete cavities and the continuous polymeric phase, which amphiphilic block copolymer has an HLB value of less than or equal to 6.