Patent ID: 8637449
Filing Date: 2014-01-28
Classification: A61P,C07K

Abstract:
1. A process for preparing compounds of Formula I, or pharmaceutically acceptable salts, solvates or hydrates thereof, wherein: p and q are independently 1 or 2; R R R Het is a 5- or 6-membered saturated cyclic ring having 1 or 2 heteroatoms selected from N, O and S, wherein said ring is substituted with from 0 to 3 substituents selected from halo, OR R R R Y is C(═O), SO Z is C(R M is C each R each W is independently halo, OR R R or R each R said process comprising a) coupling a compound of structural formula IA with a compound of structural formula IB to form a compound of structural formula IC wherein R* is selected from the group consisting of carbobenzyloxy and tert-butyloxycarbonyl; R** is selected from the group consisting of C X is selected from the group consisting of halides and sulfonides; and M′ is a C b) hydrogenating said compound of structural formula IC to form a compound of structural formula ID c) cyclizing said compound of structural formula ID to form a compound of structural formula IE d) hydrolyzing the compound of structural formula IE to provide a compound of structural formula IF and e) reacting said compound of structural formula IF with a compound of structural formula IG to provide the compound of Formula I;