Patent ID: 6048984
Filing Date: 2000-04-11
Classification: C07D

Abstract:
A compound having the formula (VII), (VIII), (IX) or (X): ##STR9## or an isomeric ester in which the position of the ring carbonyl and ester groups of formula (IX) or (X) is reversed; wherein:R.sup.2 represents:halogen;lower alkyl which is unsubstituted or is substituted by one or more halogen or --OR.sup.10 ;cycloalkyl having from three to six carbon atoms; ornitro, cyano, --CO.sub.2 R.sup.10, --NR.sup.10 R.sup.11, --S(O).sub.p R.sup.12, --O(CH.sub.2).sub.m OR.sup.10, --COR.sup.10, --N(R.sup.13)SO.sub.2 R.sup.12, --OR.sup.12, --OH, --OSO.sub.2 R.sup.12, --(CR.sup.14 R.sup.15).sub.t S(O).sub.q R.sup.12, --CONR.sup.10 R.sup.11, --N(R.sup.13)--C(Z).dbd.Y, --C(R.sup.14 R.sup.15)NR.sup.13 R.sup.16, --CH.sub.2 P(O)R.sup.10a R.sup.10b, R.sup.17, SF.sub.5, or benzyl which is unsubstituted or is substituted by from one to five R.sup.18 which are the same or different;or two groups R.sup.2, together with adjacent carbon atoms of the phenyl ring, form a second phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring which is fused to the first ring and has one or two oxygen or sulfur ring atoms and is unsubstituted or substituted by one or more halogen, lower alkyl, lower haloalkyl or lower alkoxy, or one of the ring carbon atoms of the heterocyclic ring forms part of a carbonyl group or an oxime or lower alkoxyimine thereof;n represents zero or an integer from one to three; when n is greater than one, the groups R.sup.2 are the same or different;m represents one, two or three;p and q represent zero, one or two;t represents one, two, three of four; when t is more than one, R.sup.14 and R.sup.15 are the same or different;X represents --(CR.sup.14 R.sup.15).sub.v --;v represents zero or one;R.sup.3 represents a 5-membered heteroaromatic ring of formula (VI) ##STR10## in which D, E, G and J independently represent CR.sup.9 or a nitrogen atom, with at least one of D, E, G and J representing CR.sup.19, each CR.sup.19 when more than one is present being the same or different; ortwo adjacent groups form a phenyl or a 5- to 7-membered heteroaromatic ring which is fused to the first ring and is unsubstituted or substituted by one or more R.sup.20, the 5- to 7-membered heterocyclic ring having from one to four heteroatoms in the ring which are the same or different and which are nitrogen, oxygen or sulfur;z represents one or two; when z represents two, the --XR.sup.3 groups are the same or different;L represents oxygen or NR.sup.14 ;R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.6a, R.sup.6b, R.sup.7, R.sup.7a, R.sup.7b, R.sup.8, R.sup.8a, R.sup.8b, R.sup.9, R.sup.9a and R.sup.9b represent the same or different members selected from the group consisting of hydrogen, R.sup.17, --(CH.sub.2).sub.u CO.sub.2 R.sup.14, halogen, cyano, lower alkoxy, --(CH.sub.2).sub.x -phenyl wherein phenyl is unsubstituted or is substituted by from one to five R.sup.18 which are the same or different, and cycloalkyl having from three to six carbon atoms and being unsubstituted or substituted by lower alkyl or --S(O).sub.p R.sup.22 ;u represents zero, one or two;x represents zero or one;each of R.sup.10 and R.sup.11, which are the same or different, represents hydrogen or R.sup.17 ;each of R.sup.10a and R.sup.10b, which are the same or different, represents lower alkyl or lower alkoxy;R.sup.12 represents:R.sup.17 ;cycloalkyl having from three to six carbon atoms; or--(CH.sub.2).sub.w -phenyl wherein phenyl is unsubstituted or is substituted by from one to five R.sup.18 which are the same or different;w represents zero or one;R.sup.13 represents hydrogen, R.sup.12 or OR.sup.22 ;R.sup.14 and R.sup.15 independently represent hydrogen, lower alkyl or lower haloalkyl;R.sup.16 represents --SO.sub.2 R.sup.12 or --C(Z).dbd.Y;R.sup.17 represents lower alkyl, lower haloalkyl, lower alkenyl, lower haloalkenyl, lower alkynyl or lower haloalkynyl;R.sup.18 represents halogen, R.sup.23, nitro, cyano, --CO.sub.2 R.sup.10, --S(O).sub.p R.sup.22, --OR.sup.22 or --NR.sup.10 R.sup.11 ;R.sup.19 represents hydrogen, halogen, R.sup.23, nitro, cyano, --CO.sub.2 R.sup.10, --S(O).sub.p R.sup.22, --OR.sup.22, --NR.sup.10 R.sup.11 or cyclopropyl;R.sup.20 represents halogen or R.sup.17 ;R.sup.22 represents lower alkyl or lower haloalkyl;R.sup.23 represents straight- or branched-chain alkyl having one to three carbon atoms, which is unsubstituted or is substituted by one or more halogen atoms;Y is oxygen or sulfur; Z represents R.sup.17, --NR.sup.24 R.sup.25, --SR.sup.12 or --OR.sup.12 ; andR.sup.24 and R.sup.25 independently represent hydrogen or R.sup.12.