Patent ID: 6262067
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
The crystalline forms of (2-Benzhydryl-1-azo-bicyclo[2.2. 2]oct-3-yl)-(5-isopropyl-2-methoxy-benzgi)-amine dihydrochloride having the formula ##STR2##wherein said crystalline form is selected from the group consisting ofa) a hygroscopic dihydrochloride anhydrous form;b) a nonhygroscopic dihydrochloride dihydrate, Form I polymorph exhibiting the x-ray powder diffraction patternPeak No. 1 2 3 4 5 6 7 8 d space 17.2 9.5 8.4 6.9 4.9 4.4 3.9 3.5andc) a nonhygroscopic dihydrochloride dihydrate, Form II polymorph exhibiting the x-ray powder diffraction patternPeak No. 1 2 3 4 5 6 7 8 9 d space 11.3 8.8 7.5 6.4 4.9 4.5 3.8 3.7 3.0