Patent ID: 8147482
Filing Date: 2012-04-03
Classification: A61B,A61K,A61M,A61P

Abstract:
1. An ingestible capsule for administering a drug for treatment of a disease in a gastrointestinal tract of a mammal according to a pre-determined drug release profile, the gastrointestinal tract having sites of diseased tissue and normal tissue, the capsule comprising: a drug reservoir for storing the drug; a drug dispensing device for dispensing or stopping the dispensing of the drug from the drug reservoir into the gastrointestinal tract; an electronic control circuitry communicating with the drug dispensing device for regulating amount and time interval for dispensing of the drug into the gastrointestinal tract by the drug dispensing device according to a predetermined drug release profile, wherein the electronic control circuitry further comprises a memory for storage or updating of data specific to the predetermined drug release profile for the mammal; at least one sensor configured to communicate with the electronic control circuitry; and a non-digestible outer protective shell housing the drug reservoir, the drug dispensing device and the electronic control circuitry; wherein the drug is substantially dispensed at the diseased tissue sites by the electronic control circuitry activating the drug dispensing device in response to detection of a biological condition by the at least one sensor, wherein the at least one sensor is a threshold sensor that detects a level of the biological condition crossing a predetermined threshold, and wherein the electronic control circuitry is configured to start a timer for the dispensing of the drug into the gastrointestinal tract in response to the level of the biological condition crossing the predetermined threshold.