Patent ID: 6455587
Filing Date: 2002-09-24
Classification: C07C,C07D

Abstract:
A compound of formula Ia wherein n is 1, 2, 3, 4 or 5 wherein Cx is selected from the group consisting of â€”COOH, â€”COOR5, â€”CH2OH, and â€”CONHOH, wherein R1 is selected from the group consisting of a straight or branched alkyl group of 1 to 6 carbon atoms, cyclopropylmethyl and benzyl, wherein R2 is selected from the group consisting of 4-C6H5CH2CH2CONHC6H4SO2â€”, 1-naphthyl-SO2â€”, and a sulfonyl group of formula (3) wherein R4 is selected from the group consisting of 9-fluorenylmethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl, C6H5OCH2COâ€”, C6H5SCH2COâ€”, 4-NO2C6H4CHCHCOâ€”, 9-fluorene-CH2COâ€”, 9-fluorene-COâ€”, C6H5CH2CH2COâ€”, 3-NH2C6H4CH2CH2COâ€”, 4-CH3OC6H4CH2CH2COâ€”, 3-CH3OC6H4CH2CH2COâ€”, 2-CH3OC6H4CH2CH2COâ€”, 3,4-(CH3O)2C6H3CH2CH2COâ€”, 2,3-(CH3O)2C6H3CH2CH2COâ€”, 2,4-(CH3O)2C6H3CH2CH2COâ€”, 2,5-(CH3O)2C6H3CH2CH2COâ€”, 3,5-(CH3O)2C6H3CH2CH2COâ€”, 2-CH3OC6H4CHCHCOâ€”, 3,5-(CH3O)2C6H3CHCHCOâ€”, 2,5-(CH3O)2C6H3CHCHCOâ€”, 2,4-(CH3O)2C6H3CHCHCOâ€”, and 3,4-(CH3O)2C6H3CHCHCOâ€”, wherein X, is selected from the group consisting of H, a straight or branched alkyl group of 1 to 6 carbon atoms, F, Cl, Br, I, â€”NO2, and â€”NH2 and wherein R5 is selected from the group consisting of straight and branched alkyl groups of 1 to 6 carbon atoms and when Cx is â€”COOH pharmaceutically acceptable alkali metal salts thereof, and when R2 R4 or both R2 and R4 comprises an amino group, pharmaceutically acceptable ammonium salts thereof.