Patent ID: 6794392
Filing Date: 2004-09-21
Classification: C07C,C07D

Abstract:
An anilide compound having the structure represented by formula (13): wherein A is an optionally substituted phenyl group or an optionally substituted heterocyclic group selected from the group consisting of pyridine, pyrazine, pyrimidine, pyridazine, thiophene, furan, pyrrole, isoxazole, isothiazole, imidazole, thiazole, oxazole, tetrahydrofuran, piperidine, piperazine, quinuclidine, quinoline, benzofuran, benzothiophene, indole, furopyridine, thienopyridine and pyrrolopyridine, wherein the substituent(s) for the phenyl group or the heterocyclic group is (are) 1 to 3 substituents selected from a nitro group or a cyano group or 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, an alkyl group having 1 to 4 carbons, an alkoxy group having 1 to 4 carbons, an aminoalkyl group having 1 to 4 carbons, an alkylamino group having 1 to 4 carbons, an acyl group having 1 to 4 carbons, an acylamino group having 1 to 4 carbons, an alkylthio group having 1 to 4 carbons, a perfluoroalkyl group having 1 to 4 carbons, a perfluoroalkyloxy group having 1 to 4 carbons, a carboxyl group, an alkoxycarbonyl group having 1 to 4 carbons, a phenyl group and a heterocyclic group;B is an optionally substituted phenyl group or an optionally substituted heterocyclic group selected from the group consisting of thiophene, benzofuran and benzothiophene, wherein the substituent(s) for the phenyl group or the heterocyclic group is (are) 1 to 3 substituents selected from a nitro group or a cyano group or 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, an alkyl group having 1 to 4 carbons, an alkoxy group having 1 to 4 carbons, an aminoalkyl group having 1 to 4 carbons, an alkylamino group having 1 to 4 carbons, an acyl group having 1 to 4 carbons, an acylamino group having 1 to 4 carbons, an alkylthio group having 1 to 4 carbons, a perfluoroalkyl group having 1 to 4 carbons, a perfluoroalkyloxy group having 1 to 4 carbons, a carboxyl group, an alkoxycarbonyl group having 1 to 4 carbons, a phenyl group and a heterocyclic group; Y, which links A and B is represented by formula (27): -T1-T2-T3-â€ƒâ€ƒ(27) â€ƒwherein T1 is â€”Oâ€”CH2â€”, â€”CH2â€”Oâ€”CH2â€”, â€”CH2â€”NHâ€”, â€”CH2â€”or â€”Oâ€”; T3 is â€”NHâ€”CH2â€”, â€”CH2â€”, â€”COâ€”NHâ€”, â€”COâ€” or a direct bond; when T3 is â€”NHâ€”CH2â€”, â€”CH2â€”, or a direct bond, T2 is a cyclic moiety having â€”COâ€” or â€”CSâ€”, said cyclic moiety consisting of one selected from the group consisting of an oxazolidine ring, an imidazolidine ring, a piperazine ring, a pyrrolidine ring or a cyclobutene ring, wherein one or two of said â€”COâ€” or â€”CSâ€” is formulated by combining O or S with one or two carbon atoms of the cyclic moiety; or when T3 is â€”COâ€”NHâ€” or â€”COâ€”, T2 is a cyclic moiety consisting of a pyrrolidine ring; R3 is a hydroxy or amino group; or a pharmaceutically acceptable salt thereof.