Patent ID: 6696478
Filing Date: 2004-02-24
Classification: A61K,A61P

Abstract:
A method of treating a mammal suffering from a cancer comprising the steps of administering to said mammal a chemical targeted to PKC &agr; and monitoring said mammal to determine state of said cancer;wherein said cancer is a cancer sensitive to said chemical targeted to PKC &agr;, wherein the amount administered is a quantity sufficient to constitute effective treatment, wherein said chemical is chosen from a group consisting of: A) GÃ¶6976 (trade name): C24H18N40 (formula): 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo [2,3-a] purrolo[3,4-c] carbazole (chemical name), B) C-o 002 (trade name): C23H22N4 (formula): 12-(3-Aminopropyl)-5,6,7,12,13-pentahydro-indolo [2, 3,-a] pyrrolo [3,4-c] carbazole (chemical name), and C) C-o 003 (trade name): C23H24N4Cl2 (formula): 12-(3-Aminopropyl)-5,6,7,12,13-pentahydro-indolo [2, 3,-a] pyrrolo [3,4-c] carbazole hydrochloride (chemical name) and wherein said cancer is chosen from a group of cancers consisting of: breast cancer, leukemia, lymphoma, lung cancer, bone cancer, prostate cancer gastric cancer, colon cancer, rectal cancer, liver cancer, cervical cancer, renal cancer, bladder cancer, nasopharyngeal cancer, esophagus cancer, pituitary gland tumor; thyroid cancer melanoma and pancreatic cancer.