Patent ID: 7148322
Filing Date: 2006-12-12
Classification: A61P,C07K

Abstract:
1. A process for the preparation of compounds of formula (I), unsalified forms thereof, and salts thereof in which R represents a linear or branched or cyclic chain containing up to 30 carbon atoms, optionally containing one or more heteroatoms and one or more heterocycles, the process comprising: a) a compound of formula III is provided b) the compound of formula (III) is subjected to an alkylation reaction of the alcohol in position 5 by the action of an alcohol of formula Alk-OH in the presence of pyridinium p-toluenesulfonate (PPTS), Alk representing an alkyl radical containing 1 to 4 carbon atoms, in order to obtain the compound of formula (III′) c) the compound of formula (III) or (III′) is subjected to a dehydration reaction, in order to obtain a compound of formula d) the compound of formula (IV) is subjected to a reducing amination reaction by the action of ethylene diamine in the presence of a reducing agent comprising NaBH