Patent ID: 6538005
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
An N-oxide of the compound of formula I, in whichR1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in whichR1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in whichR3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in whichR5 and R51 together represent an additional bond, R6 is SO2â€”N(R7)R8 or COâ€”N(R9)R10, where R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or an unsubstituted or R12-and/or R13-substituted phenyl radical, R8 is 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cyclo-alkylmethyl or an unsubstituted or R12- and/or R13-substituted phenyl radical, or where R7 and R8, together and including the nitrogen atom to which both are bonded, represent a 1-pyrrolidinyl, 1-piperidyl, 1-hexahydroazepinyl or 4-morpholinyl radical,R9 is hydrogen or 1-4C-alkyl, R10 is an unsubstituted or R11-substituted pyridyl radical or an unsubstituted or R12- and/or R13-substituted phenyl radical, where R11 is halogen, nitro, carboxyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkyl, trifluoromethyl or completely or predominantly fluorine-substituted 1-4C-alkoxy, R12 is hydroxyl, halogen, 1-4C-alkyl or 1-4C-alkoxy, R13 is hydroxyl, halogen, nitro, cyano, carboxyl, 1-4C-alkyl, trifluoromethyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl or completely or predominantly fluorine-substituted 1-4C-alkoxy, or a salt of this N-oxide.