Patent ID: 6465173
Filing Date: 2002-10-15
Classification: A61K,C07K,Y10S

Abstract:
A method for detecting HIV-related pathologies comprising:a) contacting an antibody-containing sample of an HIV-infected individual with an anti-idiotypic monoclonal antibody or binding fragment thereof having specific reactivity with an idiotype specifically bound by monoclonal antibody 1F7produced by hybridoma ATCC Accession No. HB 11296, and which idiotope is common to at least three types of human anti-HIV-1-antibody of differing specificities, but not significantly reactive with idiotypes of human non-HIV-1 antibodies, and b) determining if the anti-idiotypic monoclonal antibody binds to the antibody-containing sample, wherein binding indicates the presence of HIV-1antibodies having a common idiotope, thereby detecting an HIV-1-related pathology.