Patent ID: 8329725
Filing Date: 2012-12-11
Classification: A61P,C07D

Abstract:
1. Compound of the formula I wherein R1 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene —(C3-C7) cycloalkyl, (C0-C4) alkylene —(C5-C10) heteroaryl, (C0-C4) alkylene —O—(C0-C8) alkyl, (C0-C4) alkylene —(C6-C10) aryl, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; R2 is H, (C1-C8) alkyl, halogen, (C0-C4) alkylene —O—(C0-C8) alkyl, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; R3, R4 are independently H, (C1-C8) alkyl, halogen, (C0-C4) alkylene —O—(C0-C8) alkyl, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; R5, R6 are independently H, (C1-C8) alkyl, (C0-C4) alkylene —(C3-C7) cycloalkyl, (C0-C4) alkylene —(C5-C10) heteroaryl, (C0-C4) alkylene —O—(C0-C8) alkyl, (C0-C4) alkylene —(C6-C10) aryl, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; R5 and R6 together with the carbon atom carrying them form a (C3-C7) cycloalkylring, wherein one carbon atom can be replaced by one heteroatom selected from the group consisting of O, S or N; R7 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; R8 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F, whereby R8 is only attached to carbon; R9 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene —(C3-C7) cycloalkyl, (C0-C4) alkylene —O—(C0-C8) alkyl, (C0-C4) alkylene —(C6-C10) aryl, (C0-C4) alkylene —(C5-C10) heteroaryl, wherein alkyl and alkylene are unsubstituted or 1- to 3-fold substituted by F; at least one of X1, X2, X3, X4, X5 is N, the others are CH; in all its stereoisomeric forms and mixtures in any ratio, and its physiologically acceptable salts and tautomeric forms.