Patent ID: 6288055
Filing Date: 2001-09-11
Classification: A61K,A61P,C07B,C07C,C07D,C07K,C40B,G01N

Abstract:
A multibinding compound of the formula:(L).sub.p X.sub.q Formula Iin which L is a compound of formula (a) that may be the same or different at each occurrence: ##STR29##in which:n is an integer of 1-3;R.sup.1 is hydrogen, halo, cyano, haloalkyl, alkoxy, alkyl, or a covalent bond connecting the ligand to a linker;R.sup.2 is hydrogen, alkyl, or a covalent bond connecting the ligand to a linker;R.sup.3 is hydrogen, halo, or a covalent bond connecting the ligand to a linker; andR.sup.4 is hydrogen, halo, alkyl, alkenyl, alkynyl, nitro, alkoxy, or a covalent bond connecting the ligand to a linker;Q is --O--, --NR.sup.5 -- in which R.sup.5 is hydrogen, alkyl, or a covalent bond connecting the ligand to a linker), or --S(O).sub.m, in which m is 0 to 2;or a pharmaceutically acceptable salt or prodrug thereof;provided that at least one of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is a covalent bond connecting the ligand to a linker;X is a linker that may be the same or different at each occurrence;p is an integer of 2-10; andq is an integer of 1-20,each of said ligands compromising a ligand domain capable of binding to an nAChR receptor, or a salt thereof.