Patent ID: 6150129
Filing Date: 2000-11-21
Classification: A61K,C07D,C40B,Y02A

Abstract:
A method of identifying a compound having antimicrobial activity comprising:preparing a composition comprising at least three compounds, each of said compounds having the formula: ##STR26## wherein each p is independently 0, 1 or 2;each x and y are independently 1, 2 or 3;each Q.sub.1 is independently --N(R.sub.15)--, --O-- or --S--;each R.sub.2 is hydrogen, C.sub.1 -.sub.6 alkyl, C.sub.6 -C.sub.15 aryl, C.sub.7 -C.sub.20 alkaryl, pyran, pyrrolidone, benzothiazole, pyridine, benzoxazole, piperidine, piperazine, furan thiofuran pyrimidine, carbazole, or a moiety of the formula --(CH.sub.2).sub.m --R.sub.3 -R.sub.4 where:each m is 0 or 1;each R.sub.3 is --CH.sub.2 --, --C(.dbd.O)-- or --C(.dbd.S)--; andeach R.sub.4 is --O--R.sub.5, C.sub.1 -C.sub.6 alkyl, C.sub.6 -C.sub.15 aryl or pyran, pyrrolidone, benzothiazole, pyrdine, benzoxazole, piperidine, piperazine, furan, thiofuran, pyrimidine, carbazole, where R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.6 -C.sub.15 aryl, C.sub.3 -C.sub.12 cycloalkyl, pyran, pyrrolidone, benzothiazole, pyridine, benzoxazole, piperidine, piperazine, furan, thiofuran, pyrimidine, carbazole or C.sub.7 -C.sub.20 alkaryl;each R.sub.11 is independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.7 -C.sub.20 alkaryl, C.sub.6 -C.sub.20 aryl, pyran, pyrrolidone, benzothiazole, pyridine, benzoxazole, piperidine, piperazine, furan, thiofuran, pyrimidine, carbazole or C.sub.3 -C.sub.20 cycloalkyl;each R.sub.12 is independently --CH.sub.2 -- or --C(.dbd.O)--; andeach R.sub.15 is independently hydrogen or C.sub.1 -C.sub.6 alkyl;assaying said composition to determine at least one biological activity of said plurality of compounds; andidentifying which of said compounds contribute to said activity.