Patent ID: 6281194
Filing Date: 2001-08-28
Classification: A61K,A61P,C07K

Abstract:
A compound having the Formula I ##STR35##whereinR.sup.Q is ##STR36##x is 0 or 1;each R.sup.14 is independently hydrogen or C.sub.1 -C.sub.6 alkyl;A is --COR.sup.a, --CO.sub.2 R.sup.a ', --CONHR.sup.a ', --CSR.sup.a, ##STR37##--C(S)OR.sup.a ', --C(S)NHR.sup.a ', --SO.sub.2 R.sup.a, or --CONR.sup.a R.sup.a "";R.sup.a, R.sup.a ', and R.sup.a "" are independently C.sub.1 -C.sub.6 alkyl, --(CR.sup.14 R.sup.14).sub.m -cycloalkyl, --(CR.sup.14 R.sup.14).sub.m -aryl, or --(CR.sup.14 R.sup.14).sub.m -heteroaryl;each m is independently 0 to 3;R.sup.1, R.sup.2, and R.sup.4 are independently hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.3 is ##STR38##C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, --(CR.sup.14 R.sup.14).sub.m -naphthyl, --(CH.sub.2).sub.v CO.sub.2 R.sup.14, --(CH.sub.2).sub.t NR.sup.14 R.sup.14, --(CH.sub.2).sub.v --O--C.sub.1 -C.sub.6 alkyl, --(CH.sub.2).sub.t --OH, --(CH.sub.2).sub.t -morpholino, ##STR39##--(CR.sup.14 R.sup.14).sub.m -(phenyl substituted with R.sup.b), or --(CR.sup.14 R.sup.14).sub.m -(heteroaryl substituted with R.sup.b);t is 2 to 6;v is 1 to 6;R.sup.b is --O-phenyl, --O-benzyl, halogen, C.sub.1 -C.sub.6 alkyl, hydrogen, --OC.sub.1 -C.sub.6 alkyl, --NH.sub.2, --NHR.sup.a, ##STR40##--O(CH.sub.2).sub.y NR.sup.a R.sup.a ', --CF.sub.3, --NO.sub.2, ##STR41##--OPO.sub.3 H.sub.2, --CF.sub.2 CF.sub.3, --SO.sub.2 R.sup.a, --SO.sub.2 NR.sup.a R.sup.a ', --CHO, --OCOCH.sub.3, --O(CH.sub.2).sub.m -aryl, --O(CH.sub.2).sub.m -cycloalkyl, --(CH.sub.2).sub.m -aryl, --(CH.sub.2).sub.m -cycloalkyl, --(CH.sub.2).sub.m -heteroaryl, or --CH.dbd.CHC.sub.6 H.sub.5, or --O(CH.sub.2).sub.m -heteroaryl;y is 2 or 3;R.sup.5 is ##STR42##each n is independently 2, 3, or 4;R.sup.i, R.sup.g, and R.sup.h are independently hydrogen, halogen, --OC.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyl, --CN, --OPO.sub.3 H.sub.2, --CH.sub.2 PO.sub.3 H.sub.2, --O-phenyl, --O-benzyl, ##STR43##--O(CH.sub.2).sub.y NR.sup.a R.sup.a ', --NH.sub.2, --NHR.sup.a, ##STR44##--CF.sub.2 CF.sub.3, --SO.sub.2 R.sup.a, --SO.sub.2 NR.sup.a R.sup.a ', --CHO, or --OCOCH.sub.3 ; andR.sup.c and R.sup.d are independently C.sub.1 -C.sub.6 alkyl, --(CH.sub.2).sub.m -cycloalkyl or hydrogen, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof.