Patent ID: 6221906
Filing Date: 2001-04-24
Classification: A61K,A61P,C07F

Abstract:
A platinum complex conjugated to cyclotriphosphazene represented by Formula 1:Formula 1 ##STR12##(wherein N.sub.3 P.sub.3 is a cyclotriphosphazene backbone ##STR13##R is a solubilizing agent selected from the group consisting of methylamine, methoxy and amino acid;A is a monodentate neutral ligand ammonia (NH.sub.3) or as ##STR14##represents a bidentate chelating diamine selected from the group consisting of ethylenediamine (NH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2)(en), 2,2-dimethyl-1,3-propanediamine (NH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NH.sub.2)(dmpda), 2,2-bisaminomethylpropanediol (NH.sub.2 CH.sub.2 C(CH.sub.2 OH).sub.2 CH.sub.2 NH.sub.2)(bampd), and trans-(.+-.)-1,2-diaminocyclohexane ##STR15##n is the number defining the kind of anionic amino carboxylic acids and is an integer from 0 to 2; wherein 0 for amino malonic acid derivatives, 1 for aspartic acid derivatives and 2 for glutamic acid derivatives; andx is a value between 0 and 3).