Patent ID: 9051311
Filing Date: 2015-06-09
Classification: C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: R R —CF 3 , —OH, —OCF 3 , C 1-6 alkyl, —OC 1-6 alkyl, —CN, —(CH 2 ) n NR e R e , —O(CH 2 ) m OR e , —CO 2 R e , —SR e , —S(═O) 2 R e or —NR e (CH 2 ) m OR e ; A is a three to ten membered cycloalkyl, six to ten membered aryl, five to ten membered heteroaryl or three to ten membered heterocycloalkyl group, where the heteroaryl or heterocycloalkyl group can have from one to three heteroatoms independently selected from O, N or S, and where the cycloalkyl, aryl, heteroaryl or heterocycloalkyl group can be unsubstituted or substituted with from 1 to 3 substituents independently selected from halo, C R R R W is a bond; X is CR Y is CR Z is CR each R each n is independently 0 to 3; each m is independently 1 to 3; and each R provided that the compound of Formula I is not 5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-N-(1,3,4-thiadiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide or 5-(1,2,3,6-tetrahydropyridin-4-yl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide.