Patent ID: 7553641
Filing Date: 2009-06-30
Classification: A61K,A61P,C07K

Abstract:
1. A cell line producing an antibody or fragment thereof, wherein the antibody or fragment thereof specifically binds to mature human TNF-α, wherein when the antibody or fragment thereof binds mature human TNF-α, the induction of endothelial procoagulant activity is inhibited; and wherein the antibody or fragment thereof competitively inhibits sheep anti-sera raised against a TNF-α peptide for specific binding to mature human TNF-α, wherein the TNF-α peptide is a peptide consisting of residues Val wherein the antibody or fragment thereof competitively inhibits Mab 25 (ECACC Accession No. 89121401) for specific binding to mature human TNF-α; and wherein the cell line has been isolated.