Patent ID: 8507551
Filing Date: 2013-08-13
Classification: A61K,A61P,Y02A

Abstract:
1. A method of treating a Staphylococcus sp, having decreased susceptibility to a vancomycin, or for treating a vancomycin-resistant Staphylococcus sp, bacterial infection, comprising: (1) providing a pharmaceutical composition comprising a small molecule selected from 2-diethylaminoethyl-2,2-diphenyl-valerate; 2,4-dichloro-6-phenylphenoxyethylamine; 2,4-dichloro-6-phenylphenoxyethyldiethylamine; a piperonyl butoxide; or any combination thereof, that inhibits or slows the production and/or activity of a carotenoid in a bacteria; and (2) administering to a subject inflicted with the wherein a therapeutically effective dose inhibits or slows the production and/or activity of a carotenoid in the bacteria, thereby causing the bacteria to be more susceptible to oxidative damage and/or killing by neutrophils, and the therapeutically effective dose is a dose that is not directly cytotoxic to the bacteria.