Patent ID: 7576108
Filing Date: 2009-08-18
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein M is hydrogen, halo, lower alkyl, or perfluoro lower alkyl; and Rx and Ry are hydrogen, halo or methyl; and R R R R R substituted with hydrogen, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, an unsubstituted or hydroxy substituted cycloalkyl ring containing 5 or 6 carbon atoms, a five- or six-membered saturated heterocyclic ring which contains from 1 to 3 hetero atoms selected from the group consisting of sulfur, oxygen or nitrogen, or an unsubstituted five- or six-membered heteroaromatic ring, connected by a ring carbon atom, which contains from 1 to 3 heteroatoms in the ring selected from the group consisting of sulfur, nitrogen and oxygen, or —(CH 2 )n-NR 8 R 9 , with n=1, 2, and R R W is oxygen, sulfur, —SO—, —SO R10 is a heteroaromatic ring, connected by a ring carbon atom, which contains from 5 to 6 ring members with from 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur or nitrogen, or aryl containing 6 or 10 ring carbon atoms, or aryl containing from 6 ring carbon atoms fused with a heteroaromatic ring containing 5 or 6 ring members with 1 or 2 heteroatoms in the ring being selected from the group consisting of nitrogen, oxygen or sulfur, or a saturated 5- or 6-membered cycloheteroalkyl ring, which contains from 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, or a cycloalkyl ring having 5 or 6 carbon atoms, or —NR y is independently 0, 1, 2, 3 or 4; z is independently 0,1; or R U is —NHCO—, —CONH—, —NHSO R perfluoro-lower alkyl, lower alkyl, lower alkoxycarbonyl or —NR t is an integer being 0, 1, 2, 3 or 4; R s is independently 0, 1 or 2; R R R n is 0, 1, 2, 3 or 4; R and its pharmaceutically acceptable salts thereof.