Patent ID: 8735379
Filing Date: 2014-05-27
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of treating inflammation that is associated with a metabolic disorder, wherein the metabolic disease is selected from the group consisting of Type II diabetes, insulin resistance, atherosclerosis, dyslipidemia, retinopathy associated with diabetic complications, nephropathy associated with diabetic complications, neuropathy associated with diabetic complications, and macular edema associated with diabetic complications, comprising administering to a patient in need thereof an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof, wherein: R 1 , R 2 , R 3 , and R 4 are each independently selected from the group consisting of H, Cl, F, CN, —NH(C 1 -C 3 alkyl), —N(C 1 -C 3 alkyl) 2 , —NH(C(O)C 1 -C 3 alkyl), —N(C(O)C 1 -C 3 alkyl) 2 , —C(O)H, —C(O)C 1 -C 3 alkyl, —C(O)OC 1 -C 3 alkyl, —C(O)NH 2 , —C(O)NH(C 1 -C 3 alkyl), —C(O)N(C 1 -C 3 alkyl) 2 , —O—C 1 -C 3 alkyl; W 1 is NH and W 2 is selected from null or NH; - - - - - represents an optional bond that when present requires that Q is null; a and c are each independently H, CH 3 , —OCH 3 , —OCH 2 CH 3 , or C(O)OH; b is H, CH 3 , C(O)OH, or O—Z; d is H or C(O)OH; each n, o, p, and q is independently 0 or 1; each Z is H or with the proviso that there is at least one in the compound; each r is independently 2 or 3; each s is independently 5 or 6; each t is independently 0 or 1; Q is null, C(O)CH 3 , Z, e is H or any one of the side chains of the naturally occurring amino acids; W 3 is null or N(R)—; R is H or C 1 -C 3 alkyl; and T is H, C(O)CH 3 , or Z.