Patent ID: 8614307
Filing Date: 2013-12-24
Classification: A61P,C07K

Abstract:
1. An isolated nucleic acid encoding a variable heavy (VH) chain of an antibody or antigen-binding fragment thereof that binds to each one of human KIR2DL1, human KIR2DL2, and human KIR2DL3, but which does not bind human KIR2DS4, or a vector comprising said isolated nucleic acid, wherein said nucleic acid is selected from the following: (i) a nucleic acid encoding a VH chain of an antibody or antibody fragment, said heavy chain comprising a CDR1 region corresponding to amino acid residues 31-35 set forth in SEQ ID NO:17; a CDR2 region corresponding to amino acid residues 50-65 set forth in SEQ ID NO:17; and a CDR3 region corresponding to amino acid residues 99-112 set forth in SEQ ID NO:17; and (ii) a nucleic acid encoding a VH chain comprising the heavy chain CDR1, CDR2 and CDR3 regions recited in (i), and which VH chain is at least 90% identical to a VH chain comprising amino acids having the sequence set forth in SEQ ID NO: 17.