Patent ID: 8735625
Filing Date: 2014-05-27
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a compound of formula I: comprising deprotecting a compound selected from: where r is 0, 1 or 2; Ar is an aryl group selected from: Ar* is Ar—R R R 1a is H, —C 1-6 alkyl, —C 1-3 alkylenearyl, —C 1-3 alkyleneheteroaryl, —C 3-6 cycloalkyl, —CH(C 1-4 alkyl)OC(O)R 1aa , —C 0-6 alkylenemorpholine, R 1aa is —O—C 1-6 alkyl, —O-cycloalkyl, —NR 1ab R 1ac , or —CH(NH 2 )CH 2 COOCH 3 ; R 1ab and R 1ac are independently selected from H, —C 1-6 alkyl, and benzyl, or are taken together as —(CH 2 ) 3-6 —; R 1b is R 1c or —NHC(O)R 1c ; R 1c is —C 1-6 alkyl, —C 0-6 alkylene-O—R 1ca , —C 1-5 alkylene-NR 1cb R 1cc , or —C 0-4 alkylenearyl; R 1ca is H, —C 1-6 alkyl, or —C 1-6 alkylene-O—C 1-6 alkyl; R 1cb and R 1cc are independently selected from H and —C 1-6 alkyl, or are taken together as —(CH 2 ) 2 —O—(CH 2 ) 2 — or —(CH 2 ) 2 —N[C(O)CH 3 ]—(CH 2 ) 2 —; R 1d is H, R 1c , —C(O)R 1c , or —C(O)NHR 1c ; R 1e is —C 1-4 alkyl or aryl; R R X is —C R R R R wherein: each —CH each carbon atom in X is optionally substituted with one or more R each alkyl and each aryl in R each ring in Ar and each aryl in R P P P P P P