Patent ID: 7879817
Filing Date: 2011-02-01
Classification: A61K,A61P

Abstract:
1. A hyaluronic acid compound in which a non-steroidal anti-inflammatory drug is bound to hyaluronic acid through a covalent bond, wherein a partial structure of a hyaluronic acid disaccharide unit into which the anti-inflammatory drug is introduced is represented by the following formula (1): wherein Y—CO— represents the glucuronic acid residue of the hyaluronic acid disaccharide unit; R —NH—R R —CO—NH— represents an amide bond of a carboxyl group in the glucuronic acid as a constituting saccharide of the hyaluronic acid with an amino group in the spacer compound; wherein a hydroxyl group in the spacer compound forms an ester bond with a carboxyl group in the non-steroidal anti-inflammatory drug residue; and n is an integer of from 1 to 3, wherein the hyaluronic acid compound has a degree of substitution of the non-steroidal anti-inflammatory drug of from 5 to 50 mol % per repeating disaccharide unit of hyaluronic acid, and the carbonyl group in a hyaluronic acid residue constituting the hyaluronic acid compound is present as an amide bond participating in the binding with the spacer-binding anti-inflammatory drug residue or as a free carboxyl group not participating therein, according to the degree of substitution of the non-steroidal anti-inflammatory drug residue.