Patent ID: 9072697
Filing Date: 2015-07-07
Classification: A61K,A61P

Abstract:
1. A method comprising: orally administering to a human subject with Parkinson's disease once-daily a composition consisting of (i) a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and (ii) at least one excipient, wherein at least 50% of the drug in the composition is in an extended release form, and wherein the composition has an in vitro dissolution profile ranging between 35% and 55% in 2 hours, 60% and 80% in 4 hours, and greater than 90% in 8 hours using a USP type 2 (paddle) dissolution system at 50 rpm at a temperature of 37±0.5° C. in water, and wherein the daily dose of drug administered to the human subject is 200 to 500 mg.