Patent ID: 6472387
Filing Date: 2002-10-29
Classification: A61P,C07D

Abstract:
A method of treating a disease selected from the group consisting of Alzheimer's disease, Parkinson's disease, amytrophic lateral sclerosis or cerebral trauma in a mammal in need of such treatment which comprises administering to said mammal a lipid peroxidation inhibitory amount of a compound of formula (III) wherein:Ar is phenyl, pyridyl, tetrahydronaphthyl, benzofuranyl or chromanyl substituted with zero to two substituents selected from the group consisting of â€”(C1-C6)alkyl, hydroxy and halo; and substituted with one or two substituents selected from the group consisting of â€”O(CH2)tR6, and â€”(C1-C6 alkyl)R6;provided that the phenyl or pyridyl group of Ar may additionally be substituted with two substituents which when taken together with the carbon atoms to which they are attached form a phenyl ring; where R6 is â€”NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-y1, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with â€”(C1-C4)alkyl or and R7 and R8 are each individually hydrogen, â€”(C1l-C6)alkyl, â€”(CH2)pOH, â€”(CH2)p-piperidyl, â€”(CH2)pS(C1-C6)alkyl, â€”(CH2)pO(C1-C6)alkyl where R9 is (C1-C6)alkyl;  represents a double or single bond; X is â€”Oâ€” or â€”Sâ€”; Y is â€”CR5â€²R5â€”, â€”Oâ€” or â€”Sâ€”, where R5â€² is H and R5 is â€”H or â€”OH or R5 and R5â€² taken together are &boxH;O; R is R or â€”(C1-C6)alkyl; R1 and R2 are each individually â€”(C1-C6)alkyl, â€”(C1-C6)alkoxy or phenyl; R3 is H or â€”(C1-C6)alkyl; R4 is hydrogen or â€”OH, or when Y is â€”CHR5, R4 and R5 are each individually H or when taken together form a bond; m is an integer from 0 to 2, both inclusive; q is 0 or 1; n is an integer from 0 to 4 both inclusive; p is an integer from 1 to 6 both inclusive; and t is an integer from 1 to 4 both inclusive; or a pharmaceutically acceptable salt, hydrate or optical isomer thereof.