Patent ID: 6083744
Filing Date: 2000-07-04
Classification: A61K,C07H,C12N

Abstract:
A compound comprising the structure: ##STR4## wherein each X represents a nucleotide which is the same or different; wherein each of A, C, U and G represents a nucleotide;wherein any nucleotide in the compound may be modified in its sugar, phosphate or base, and an least one nucleotide in the compound is modified in its sugar;wherein N represents any nucleotide;wherein (X)n and (X)n' represent oligonucleotides in which n and n' are integers which define the number of nucleotides in the oligonucleotides, such oligonucleotides having predetermined sequences sufficiently complementary to a predefined RNA target sequence to allow hybridization to the RNA target sequence;wherein each solid line represents a covalent bond between the nucleotides located on either side thereof;wherein m represents an integer from 2 to 20; and wherein none of the nucleotides (X)m are Watson-Crick base paired to any other nucleotide within (X)m.