Patent ID: 6727359
Filing Date: 2004-04-27
Classification: C07D

Abstract:
A method for preparing Acesulfame, 6-METHYL-3.4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE, comprising steps of:(a) using the Substituted sodium phenoxide or the substituted phenol reacted with sulfonyl chloride in a suitable inert solvent under catalysis to produce substituted phenoxide sulfonylchloride, Compound I; (b) reacting Compound I with ammonia under catalysts to produce substituted phenoxide sulfonyl-amide, Compound II; (c) reacting Compound II with diketene in an organic solvent under amine catalysts to produce Acetoacetamide-N-sulfonyl-substituted phenoxide, Compound III; (d) dissolving Compound III in lower alcohol and addition of alkali metal hydroxide or carbonate so that cyclization of Compound II!will occur to produce Acesulfame, 6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE, and (e) isolating the produced Aceaulfame-K, Potassium salt of 6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE.