Patent ID: 6573277
Filing Date: 2003-06-03
Classification: A61P,C07D

Abstract:
A compound of formula I or an optionally stereoisomeric farm of the compound of the formula I, or a physiologically tolerable salt of the foregoing, where in the case (i):R1 is (1) a radical of formula III â€ƒor (2) a radical of the formula V â€ƒwhere o is the number 1 or 2 and one of the carbon atoms in the ring is optionally replaced by â€”Oâ€” or â€”Sâ€”: and Q as part of the compound of formula I is structural moiety (X) R3 is (1) a hydrogen atom, (2) (C1-C5)-alkyl, (3) (C1-C5)-alkoxy, (4) halogen, (5) hydroxyl, or (6) â€”Oâ€”C(O)â€”R10, where R10 is 6.1 (C1-C6)-alkyl, 6.2 (C3-C6)-cycloalkyl, 6.3 benzyl, or 6.4 phenyl; R6, R7, and R8 are identical or different, and each is (1) a hydrogen atom, or (2) 2.1 hydroxyl, 2.2 â€”Oâ€”R10, where R10 is 2.2.1 (C1-C6)-alkyl, 2.2.2 (C3-C6)-cycloalkyl, 2.2.3 benzyl, or 2.2.4 phenyl, 2.3 â€”COOH, 2.4 (C1-C6)-alkyl, 2.5 (C3-C6)-cycloalkyl-Oâ€”(C1-C4-alkyl, 2.6 halogen, 2.7 â€”CN, 2.8 â€”NO2, 2:9 â€”CF3, 2.10 â€”Oâ€”C(O)â€”R10, where R10 is as defined above, 2.11 â€”Oâ€”C(O)-phenyl, mono- or disubstituted by R3, 2.12 â€”C(O)â€”Oâ€”R10, where R10 is as defined above, 2.13 methylenodioxo, 2.14 â€”C(O)â€”NR11R12, where R11 and R12 are identical or different and each is 2.14.1 a hydrogen atom, 2.14.2 (C1-C4-alkyl, 2.14.3 benzyl or 2.14.4 R11 and R12 together with the linking nitrogen atom form a pyrrolidine, piperidine, morpholine or piperazine radical, or 2.15 â€”NR13R14, where R13 is a hydrogen atom or (C1-C4)-alkyl, and R14 is 2.15.1 a hydrogen atom, 2.15.2 (C1-C4-alkyl, 2.15.3 benzyl, 2.15.4 â€”C(O)â€”R10, or 2.15.5 â€”C(O)â€”Oâ€”R10, and R10 is as defined above; n is 1, and m is 1; and X is (1) a covalent bond, (2) â€”Oâ€”, (3) â€”Sâ€”, (4) â€”S(O)â€”, (5) â€”S(O)2â€”, (6) â€”C(O)â€”, or (7) â€”C(OH)â€”; Y is (1) â€”Oâ€” or (2) â€”Sâ€”; A is HOâ€”NHâ€”C(O)â€” or HOâ€”C(O)â€”; and B is (1) â€”(CH2)qâ€”, where q is zero, 1, 2, 3 or 4, or (2) â€”CH&boxH;CHâ€”.