Patent ID: 9121020
Filing Date: 2015-09-01
Classification: A61K,A61P,C12N

Abstract:
1. A method of treating a patient suffering, or at risk of suffering, from an ocular disease, an ocular disorder or an ocular injury, comprising administering to the patient a therapeutically effective amount of a double-stranded oligonucleotide having the structure: wherein each of A, C, U and G is a nucleotide and each consecutive nucleotide is joined to the next nucleotide by a phosphodiester bond; wherein the sense strand comprises, counting from the 5′ terminus, an unmodified ribonucleotide at each of positions 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 and 19, a L-deoxycytidine at position 18, and an inverted deoxyabasic moiety (iB) covalently attached at the 5′ terminus; and wherein the antisense strand comprises, counting from the 5′ terminus, a