Patent ID: 8236853
Filing Date: 2012-08-07
Classification: C12P

Abstract:
1. A method of generating stereospecific heterocyclic compounds, comprising the step of: providing a cyclic dienic derivative, wherein the cyclic dienic derivative is a meso diacetate; desymmetrizing the cyclic dienic derivative with a stereospecific lipase to generate an asymmetric monoacetate, wherein the stereospecific lipase is obtained from generating a substituted cis diol from the asymmetric monoacetate, further comprising: generating a substituted asymmetric monoacetate from the substituted cis diol, further comprising: intramolecular cyclizing the asymmetric monoacetate using a palladium (0) catalyst in the presence of a base to form a stereospecific heterocyclic compound.