Patent ID: 8815824
Filing Date: 2014-08-26
Classification: A61P,C07K,C12N,C12Q,C12Y,G01N

Abstract:
1. A method for inhibiting fibrosis, tumor growth, or tumor metastasis, in a subject, the method comprising: administering a polynucleotide to the subject, thereby inhibiting fibrosis, tumor growth, or tumor metastasis, wherein the tumor is breast adenocarcinoma, fibrosarcoma or melanoma, wherein the polynucleotide comprises: a first sequence comprising a nucleic acid sequence of SEQ ID NO: 20 or SEQ ID NO: 21, a second sequence comprising a region of complementarity to the nucleic acid sequence of SEQ ID NO: 20 or SEQ ID NO: 21, wherein the region of complementarity is at least 19 bases in length, and a linking sequence that joins the first sequence to the second sequence, wherein the polynucleotide forms a hairpin-loop structure having a double-stranded stem region of between 19 and 21 base pairs in length that comprises the region of complementarity, wherein ends of the double-stranded stem region are connected by the linking sequence.