Patent ID: 9149545
Filing Date: 2015-10-06
Classification: A61K,B82Y,C01G,C01P,C09C

Abstract:
1. A method for making an injectable solution for use in X-ray/computed tomography, comprising: a) providing a first precursor material comprising tantalum; b) forming an active core from the first precursor material, the core comprising tantalum in a non-zero valent state; c) providing a second precursor material; d) forming a passive shell from the second precursor material, wherein the passive shell is disposed about the core such that the core and the shell form a core/shell nanoparticle; e) forming a raw ensemble of nanoparticles and fractionating the raw ensemble; wherein fractionating comprises filtering the ensemble; and f) preparing the injectable solution of the ensemble nanoparticle in saline; wherein the passive shell comprises polyethylene imine, polyvinylsulfate, polyvinylpyrrolidinone, citrate, malate, glycolate, silanes, or combinations thereof; and wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.