Patent ID: 6933116
Filing Date: 2005-08-23
Classification: A61K,A61P,B82Y,C07H,C07K,C12N,C12Q,C40B,F02B,G01N

Abstract:
1. A method for identifying a nucleic acid binding protein's binding site on a region of a DNA or RNA comprising: a) providing a nucleic acid ligand to the nucleic acid binding protein wherein said ligand has a sequence and a structure selected from the group consisting of loops, stems, hairpins, pseudoknots, helices and bulges; b) adding said nucleic acid ligand to said nucleic acid binding protein and said DNA or RNA region; and c) determining whether said added nucleic acid ligand inhibits said protein from binding to said RNA or DNA region, whereby if the nucleic acid ligand is inhibitory, the sequence or structure of said inhibitory nucleic acid ligand assists in the identification of the binding site in the DNA or RNA region or its structure.