Patent ID: 6121321
Filing Date: 2000-09-19
Classification: A61K

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula II or a pharmaceutically acceptable salt thereof: ##STR3## wherein R and R.sub.1 are independently selected from the group consisting of hydrogen, hydroxy, lower alkyl, lower alkoxy, amino, lower dialkylamino, and halogen;R.sub.2, R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, hydroxy, halogen, lower alkoxy or lower alkyl, lower dialkyl amino, mercapto and alkyl mercapto;at least two of R.sub.5, R.sub.6 and R.sub.7 are lower alkoxy and the third is selected from the group consisting of hydrogen, hydroxy, halogen, lower alkoxy and lower alkyl; with the proviso that when at least one of R.sub.2, R.sub.3 or R.sub.4 is lower alkoxy, then each of R.sub.5, R.sub.6 and R.sub.7 are lower alkoxy;R.sub.8 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, phenyl, halo(lower)alkyl, hydroxy(lower)alkyl, acetoxy(lower)alkyl, benzyloxy(lower)alkyl, or (lower)alkyl(lower)alkoxy, or (lower)dialkylamino-(lower)alkyl;R.sub.9 is selected from the group consisting of hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or aryl; andM is selected from the group consisting of hydroxy, lower alkoxy, amino, alkylamino, dialkylaminio, benzylamino, anilino, N-morpholino, hydroxyalkyl amino, hydroxy amino, dialkylaminoalkylamino, aminoalkylamino, and the group O-Cat, wherein Cat is a pharmaceutically acceptable cation.