Patent ID: 6673600
Filing Date: 2004-01-06
Classification: A01K,A61P,C07K

Abstract:
A transgene, comprising:a) an isolated polynucleotide encoding an amyloid precursor protein (APP) or a part thereof, wherein the APP peptide or part thereof contains an AB peptide, and wherein the isolated polynucleotide encodes the 100 carboxyterminal amino acids of APP, beginning with the sequence of the AB peptide and ending with the carboxy terminal amino acid of APP (C100 fragment); b) a promoter for expression of the transgene in a cell of the nematode Caenorhabditis elegans (C. elegans); and c) an additional coding nucleotide sequence and an additional non-coding nucleotide sequence, wherein the APP peptide or part thereof is cleavable by a secretase for identifying and measuring the activity of a secretase, wherein said secretase is gamma-secretase, and wherein the polynucleotide encoding APP or part thereof and the additional coding and noncoding nucleotide sequences comprise SEQ ID NO: 5.