Patent ID: 8017625
Filing Date: 2011-09-13
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a condition mediated at least in part by hypoxia inducible factor (HIF) and/or erythropoietin (EPO), wherein said condition is selected from the group consisting of anemic disorders, neurological disorders and/or injuries, stroke, trauma, epilepsy, neurodegenerative disease, myocardial infarction, liver ischemia, renal ischemia, peripheral vascular disorders, ulcers, burns, chronic wounds, pulmonary embolism, and ischemic-reperfusion injury, comprising administering to a mammalian patient a therapeutically effective amount of a compound of formula ID: wherein q is zero or one; R R R R″ is selected from the group consisting of hydrogen, alkyl and substituted alkyl; and R′″ is selected from the group consisting of hydroxy, alkoxy, substituted alkoxy, acyloxy, cycloalkoxy, substituted cycloalkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, aryl, and —S(O) or a pharmaceutically acceptable salt, ester, or amide derived from an amine of the formula HNR with the proviso that when R″ is hydrogen and q is zero, then at least one of the following occurs: 1) R 2) R a) when R b) —XR c) when —XR where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 3) R a) when R b) —XR c) when —XR where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 4) R a) when R b) —XR c) when —XR where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 5) R a) when R b) —XR c) when —XR where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); and with the further following proviso: that when R