Patent ID: 7645886
Filing Date: 2010-01-12
Classification: A61P,C07D

Abstract:
1. A method for the manufacture of a compound of formula II defined below, comprising a method for the manufacture of amides of the formula II, wherein n is a number from 0 to 4, each R R2 is hydrogen or unsubstituted or substituted alkyl, unsubstituted or substituted alkoxycarbonyl, unsubstituted or substituted arylsulfonyl, unsubstituted or substituted alkylsulfonyl, unsubstituted or substituted aryl, carbamoyl or N-mono- or N,N-disubstituted carbamoyl, silyl substituted by three moieties independently selected from unsubstituted or substituted alkyl and substituted or unsubstituted aryl, or acyl, and R3 and R4 are, independently of each other, unsubstituted or substituted alkyl or together form an unsubstituted or substituted alkylene bridge (thus forming a ring with the binding nitrogen) or an alkylene bridge to which a phenyl or a C where a starting material of the formula III, wherein n, R 1 and R2 have the meanings given under formula II and NB is a tertiary nitrogen base where the nitrogen is not part of a ring, is reacted (b) with an active amido carbonic acid derivative of the formula V, wherein X is halogen and R3 and R4 are as defined under formula II, to give the corresponding compound of the formula II.