Patent ID: 8252959
Filing Date: 2012-08-28
Classification: C07C,C07F

Abstract:
1. Process for the preparation of an alpha-hydroxy ketone of the formula I by converting a 1,1-dicarbo substituted oxirane of the formula II wherein n ranges from 1 to 4; A A A A A or A Ar stands for a divalent carbocyclic aryl which is unsubstituted or substituted by OPr, NR Aro stands for aryloxy which is unsubstituted or substituted by OPr, NR Pr stands for hydrogen or a protecting group; R R R R R R R R R R wherein the 1,1-dicarbo substituted oxirane is subjected to aerobic oxidation in the presence of water and in the presence of a transition metal catalyst selected from a group consisting of Pd, Ru, Cu, Fe, Mn, Co, Mo, W, V, Ti, Ta, and Pt catalysts; wherein the transition metal catalyst is a complex having an organic chelating ligand bonded to the transition metal as central atom.