Patent ID: 8224580
Filing Date: 2012-07-17
Classification: G16B,G16C

Abstract:
1. A method of selecting crossover points between two or more biomolecules, the method comprising: i) providing a reference sequence of a reference biomolecule; ii) generating a contact map for the reference sequence, the contact map identifying proximal elements of the reference sequence; iii) providing a first sequence of a first biomolecule and a second sequence of a second biomolecule, between which one or more crossover points are to be determined; iv) aligning the first sequence and the second sequence with the reference sequence and selecting a crossover point between a first subsequence from the first sequence and a second subsequence from the second sequence; v) replacing the first subsequence from the first sequence with the second subsequence from the second sequence to produce a chimeric biomolecule sequence, wherein the first subsequence of the first sequence and the second subsequence of the second sequence terminate at the selected-crossover point; vi) aligning the chimeric biomolecule sequence with the reference sequence and arranging the chimeric biomolecule sequence in the contact map for the reference sequence to select two or more elements in the chimeric biomolecule sequence that correspond to the proximal elements of the reference sequence such that the alignment between the chimeric biomolecule sequence and the reference sequence is preserved during selection of the two or more elements; and vii) scoring the two or more elements selected in vi) by considering the interaction of said elements with one another, wherein scoring provides a measure of the likelihood of a new biomolecule comprising the two or more elements having a property similar or identical to the reference biomolecule, wherein at least operation iv) is performed by executing instructions on a computer system programmed to perform said operation.