Patent ID: 6541265
Filing Date: 2003-04-01
Classification: G01N

Abstract:
A method for screening a substance for inflammatory or oxidant properties comprising:(a) applying an eccentric exercise stimulus to a subject, thereby inducing a muscle injury in the subject; (b) administering a substance to the subject; (c) measuring at least one biological marker from said subject to obtain a value of said biological marker, wherein said biological marker is selected from the group consisting of free iron, total antioxidant status, 8-isoprostane, superoxide dismutase, glutathione peroxidase, lactate dehydrogenase, C-reactive protein, lipid hydroperoxidase, myeloperoxidase, interleukin-6, dityrosine, and 8-hydroxyguanine; and (d) correlating the measured value of said biological marker with the inflammatory or oxidant properties of said substance.