Patent ID: 6022955
Filing Date: 2000-02-08
Classification: A61K,C07K

Abstract:
A purified composition of matter consisting of a covalently linked compound in physical admixture with at least one lipid, wherein said covalently linked compound consists of two parts and has the structural formula: FA-SPC, wherein -SP-C is protein selected from the group comprising human, porcine, canine and bovine surfactant associated protein C (SP-C) produced by chemical or enzymatic synthesis or recombinant DNA means, wherein said SP-C protein comprises a sequence of thirty-four (34) amino acids, said sequence containing eleven (11) valine amino acid residues, nine (9) of said valine residues being contained in two (2) adjacent polyvaline stretches, said polyvaline stretches having a first stretch of six adjacent valine amino acid residues and a second stretch of three adjacent valine amino acid residues separated from the first stretch by two hydrophobic amino acid residues, said SP-C protein enhances surfactant-like activity of phospholipids in lungs of an animal, and is substantially resistant to protease, endoglycosidase F and collagenase enzymes, and wherein FA- is a single fatty acid selected from the group comprising fatty acids having a carbon chain length from two(2) to about twenty(20) carbon atoms and wherein said fatty acid is covalently attached to the amino end terminal amino acid residue of said SP-C.