Patent ID: 7026316
Filing Date: 2006-04-11
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: X is selected from —S—, —S(O)—, —S(O) 2 —, —CH 2 —, —CHF—, and —CF 2 —; Y is selected from CH—(C 0-4 alkyl-R 2 ) and N—R 3 ; m is an integer selected from 0, 1 and 2, and n is an integer selected from 0, 1 and 2, with the proviso that the sum of m+n is 1 or 2; R 1 is selected from hydrogen and —CN; R 2 is selected from the group consisting of: (1) —NR (2) —NR (3) —NR (4) —NR (5) —NH (6) —NR (7) —S(O) (8) —CO—NR (9) —O—CO—NR (10) —OH, (11) —O—R (12) —R (13) hydrogen, with the proviso that R R 3 is selected from the group consisting of: (1) —CO—NR (2) —CO (3) —COR (4) —S(O) (5) —R (6) hydrogen, with the proviso that R R 4 and R 5 are independently selected from hydrogen and C 1-6 alkyl; R 6 is independently selected from: (1) C (2) phenyl, phenyloxy, C (3) heterocycle, and C and pharmaceutically acceptable salts thereof and individual diastereomers thereof.