Patent ID: 6774110
Filing Date: 2004-08-10
Classification: C07D

Abstract:
A compound having formula (I) and pharmaceutically acceptable salts thereofwherein n is 1 or 2; A is hydrogen, C1-6 alkyl, aryl, â€”SO2R1, â€”PO(OC1-6 alkyl)2, â€”PO(C1-6 alkyl)2, â€”CO(C1-6 alkyl), â€”CO2R2, or â€”(CH2)mCO2(C1-6 alkyl), wherein R1 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, aryl, â€”(CH2)maryl or â€”NR3R4 R2 is C1-6 alkyl, C3-7 cycloalkyl, aryl, â€”(CH2)maryl or alkenyl, and m is 1, 2 or 3, wherein aryl is unsubsituted, substituted phenyl or 5-6 membered aromatic heterocyclic ring, and R3 and R4 are independently hydrogen, C1-6 alkyl or C3-7 cycloalkyl; B is hydrogen; C and D are both phenyl unsubsituted or substituted with one or two substituents selected from C1-4 alkyl, C1-4 alkoxy, methylenedioxy, halogen, hydroxy and NR4R5, or C3-7 cycloalkyl; E, F, and H are independently CR5 or N and G is N, wherein R5 is hydrogen, C1-4 alkyl, C1-4 alkoxy, CF3, halogen, hydroxy or â€”NR3R4; and I is â€”C(NH)NH2, â€”C(NH2)NOH, or â€”CH2NH2.