Patent ID: 8034931
Filing Date: 2011-10-11
Classification: A01N,C07D

Abstract:
1. A process for producing a substituted aminoquinazolinone represented by formula (I): (wherein R, R 1 , R 2 , X and n are as defined below), which comprises reducing a substituted iminoquinazolinone represented by formula (II): (wherein R is a hydrogen atom; a formyl group; a (C 1 -C 6 )alkyl group; a (C 1 -C 6 )alkoxy(C 1 -C 3 )alkyl group; a (C 1 -C 6 )alkylsulfonyl group; a cyano(C 1 -C 3 )alkyl group; a (C 1 -C 6 )alkylcarbonyl group; a (C 1 -C 6 )alkoxycarbonyl group; a (C 1 -C 3 )alkoxy(C 1 -C 6 )alkylcarbonyl group; a (C 3 -C 6 )cycloalkylcarbonyl group; a phenylcarbonyl group; a substituted phenylcarbonyl group having 1 to 5 substituents which may be the same or different and are selected from the group consisting of a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkylthio group, a halo(C 1 -C 6 )alkylthio group and a phenyl group; a phenylsulfonyl group; a substituted phenylsulfonyl group having 1 to 5 substituents which may be the same or different and are selected from the group consisting of a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkylthio group and a halo(C 1 -C 6 )alkylthio group; or a naphthylcarbonyl group, R R each of Xs, which may be the same or different, is a halogen atom, a (C wherein the catalyst is a palladium-based catalyst; the additive is iodine, iodobenzene, 2-iodoacetamide, N-iodosuccinimide, 5,5-dimethyl-1,3-diiodohydantoin, palladium iodide, 1-iodo-2-methylpropane, lithium iodide, sodium iodide, potassium iodide, dimethyl sulfoxide or diphenyl sulfoxide.