Patent ID: 8193229
Filing Date: 2012-06-05
Classification: A61P,C07D

Abstract:
1. A method of alleviating or inhibiting the progress of cancer in a mammal, wherein said cancer is lung cancer, squamous cell cancer, pancreatic cancer, breast cancer, head cancer, neck cancer, colorectal cancer or melanoma, said method comprising administering to said mammal in need thereof an effective amount of a compound of the formula or a pharmaceutically accepted salt thereof, wherein: R R R′, R″ and R′″ independently are selected from hydrogen, C R″″ is selected from C any two of R′, R″, R′″ or R″″ can be taken together with the atom to which they are attached to form a 4 to 10 membered heteroaryl or heterocyclic ring, each of which is optionally substituted with one to three groups independently selected from halogen, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl; or R R R R R A is selected from —OR R m is 0, 1, 2, 3, 4 or 5; and j is 1 or 2.