Patent ID: 8669368
Filing Date: 2014-03-11
Classification: C07D,C07F

Abstract:
1. A process for the preparation of a compound of formula I, or a salt thereof, where Ar 1 is phenyl substituted with 0-3 substituents selected from the group consisting of cyano, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, and alkylSO 2 comprising the reductive amination and alcohol deprotection of a compound of formula IV, or a salt thereof, where R 1 is selected from the group consisting of trialkylsilyl, alkoxy, alkylcarbonyl, benzyl, benzoyl, and pivaloyl to a compound of formula II, or a salt thereof, where R 1 is hydrogen, and coupling the compound of formula II with a compound of formula III, or a salt thereof, where R 2 is selected from the group consisting of imidazolyl, pyrrolyl, N-hydroxysuccinimidyl, chloro, phenoxy, substituted phenoxy, phenylthio, and substituted phenylthio