Patent ID: 6639089
Filing Date: 2003-10-28
Classification: A61K,A61P

Abstract:
An anticancer agent comprising, as an active ingredient, at least one compound selected from the group consisting of:an &ohgr;-hydroxy fatty acid represented by general formula (1) or a salt or ester thereof: HOâ€”R1â€”COOHâ€ƒâ€ƒ(1) â€ƒwherein R1 is a straight carbon chain having 10 to 25 carbon atoms, with no or one double bond, where an alkyl or alkylene group having 1 to 4 carbon atoms or a hydroxyl group may be linked to any position as a side chain; a hydroxy oxo-fatty acid represented by general formula (2) or a salt or ester thereof: R2â€”COOHâ€ƒâ€ƒ(2) â€ƒwherein R2 is a saturated straight carbon chain having 9 to 25 carbon atoms, with at least one carbonyl group and at least one hydroxyl group, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain; a lactone represented by general formula (3): â€ƒwherein R3 is a carbon chain having 2 to 24 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, or a carbon chain having 8 to 24 carbon atoms with at least one oxygen atom in any position which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain; R4 is hydrogen, a hydroxyl group, or a carbon chain having 1 to 30 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position; and the dashed line represents a single bond or a double bond; a macrocyclic ketone represented by general formula (4): â€ƒwherein R5 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms; R6 is a carbon chain having 7 to 17 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain; R7 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms; and the dashed line represents a single bond or a double bond; and a macrocyclic diester represented by general formula (5) â€ƒwherein R8 is a carbon chain having 2 to 10 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position; and R9 is a carbon chain having 8 to 20 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position.