Patent ID: 6838562
Filing Date: 2005-01-04
Classification: A61K,A61P,C07D

Abstract:
1. A process for the synthesis of creatine orotic acid, thioorotic acid, and dihydroorotic acid salt comprising the steps of: a) mixing creatine with water appetent organic alcohol solvents, other water appetent organic solvents, or water at a temperature of 1 to 100 degree Celsius, b) reacting the product of step a) with orotic acid, thioorotic acid, or dihydroorotic acid at a temperature of 1 to 100 degree Celsius; C) filtering to remove the solvent and washing the residue with water appetent organic alcohol solvents, other water appetent organic solvents, or water for the recovery of a mono, di, or tricreatine orotic acid, thioorotic acid, and dihydroorotic acid salt.