Patent ID: 9126981
Filing Date: 2015-09-08
Classification: A61P,C07C,C07D

Abstract:
1. A compound having the following general formula (II): wherein A is —(CHR 7 )—; wherein R B and E are the same or different and independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl, and wherein B and E do not form an optionally substituted spiro ring indicated by dashed lines; G is —NH—, —NR 6 —, —O—, —CH 2 —, —CHR 6 — or —C(R 6 ) 2 —; wherein each R R 1 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, or optionally substituted heterocycloalkylalkyl; R 2 is —W 21 —W 22 —Rb—R 20 ; wherein W W Rb is bond or optionally substituted lower alkylene; and R R 3 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl; R 91 is selected from optionally substituted alkyl, linker and solid support; and R 92 is selected from optionally substituted alkyl, linker and solid support; with the proviso that 1) when Rb is optionally substituted lower alkylene, then W 22 should be —O— or —NH—, 2) when E and B are hydrogen, then R 3 should be hydrogen, 3) when G is —NH—, —CH 2 —, —CHR 6 — or —NR 6 —, then B and E should not be hydrogen, and 4) when G is —O—, B and E are hydrogen and R 3 is hydrogen, then R 1 should not be 8-quinolylmethyl; or a salt thereof.