Patent ID: 8883160
Filing Date: 2014-11-11
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated DNL complex comprising: a) a first fusion protein comprising (i) an antibody selected from the group consisting of hRS7 (anti-EGP-1), hA20 (anti-CD20), hLL2 (anti-CD22) and hL243 (anti-HLA-DR), and (ii) an AD moiety, wherein the amino acid sequence of the AD moiety is from the anchoring domain of an AKAP (A-kinase anchoring protein); and b) a second fusion protein comprising (iii) ranpirnase, and (iv) a DDD moiety, wherein the amino acid sequence of the DDD moiety is from the dimerization and docking domain of human protein kinase A regulatory subunit R1α, R11α or R11β; wherein two copies of the DDD moiety form a dimer that binds to one copy of the AD moiety to form the DNL complex.