Patent ID: 6465491
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of the formula (1) or a pharmaceutically acceptable salt thereof whereinR1 and R2 form, together with the nitrogen to which they are attached, does not form a ring or N R1 and R2 form a piperidine or pyrrolidine ring; or R1 and R2 are selected, independently, from (C1-C6) alkyl, tetrahydronaphthalene and aralkyl, wherein the aryl moiety of said aralkyl is phenyl or naphthyl and wherein said (C1-C6) alkyl or said tetrahydronaphthalene group or the aryl ring of said aralkyl group may optionally be substituted with from one to three substituents, that are selected, independently, from halo, nitro, hydroxy, cyano, amino, (C1-C4) alkoxy, and (C1-C4) alkylamino; n is 0, 1 or 2; and each carbon of said (CH2)n can optionally be substituted with a substituent R8; m is 0, 1, or 2; and each carbon of said (CH2)m can optionally be substituted with a substituent R9; each R8 and each R9 is selected, independently, from (C1-C4)alkyl, aryl-(C1-C4)alkyl wherein said aryl is selected from phenyl and naphthyl; allyl and phenallyl; X and Y are selected, independently, from methyl, methoxy, hydroxy and hydrogen; R 10 is hydrogen or (C1-C6) alkyl; and with the proviso that R8 is absent when n is zero and R9 is absent when m is zero.