Patent ID: 9005447
Filing Date: 2015-04-14
Classification: A61K,C07B

Abstract:
1. A procedure for the preparation of purified radioactive tracer 3′-deoxy-3′-18[F]fluorothymidine ([ 18 F]FLT), comprising the following steps: a) preparing anhydrous [ b) labeling a precursor with the anhydrous [ c) adding HCI to the precursor mixture to achieve hydrolysis of the labelled precursor, thereby yielding a product mixture comprising [ d) purifying the product mixture to obtain the purified radioactive tracer [ 1) passing the product mixture through a ventilated filter to yield a filtrate, 2) passing the filtrate through one or more cartridges of the cationic exchange type to yield a first eluate, 3) passing the first eluate through one or more cartridges of the reverse phase type to yield a second eluate, and 4) passing the second eluate through a cartridge of the alumina N type to yield the purified radioactive tracer [ wherein the first eluate, the second eluate, and the purified radioactive tracer [ wherein the radiochemical purity of the purified radioactive tracer [