Patent ID: 6030614
Filing Date: 2000-02-29
Classification: A61M,A61P,C07K

Abstract:
A method to ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient, comprising:(a) providing a sterile and pyrogen-free column coupled to anti-human immunoglobulin antibodies, wherein the pyrogen content of the column matrix material is below 0.25 EU/mL,(b) passing plasma of the human recipient over the column under conditions which effect the binding of said anti-human immunoglobulin antibodies to immunoglobulin in the recipient's plasma, thereby removing at least 50% of the immunoglobulin from said plasma, and recovering a column effluent, and(c) reinfusing said effluent to the recipient, and thereby ameliorating hyperacute or acute rejection of a human donor organ transplanted to the recipient.