Patent ID: 8758804
Filing Date: 2014-06-24
Classification: A61K

Abstract:
1. A device for controlled local delivery of rifaximin to a mucosa of a body, the device comprising: rifaximin; and a bi-phasic material comprising a solid phase and a liquid phase, wherein the solid phase is an elastic polymeric matrix comprising polyvinylalcohol, and the liquid phase comprises water that fills up the pores of said polymeric matrix to form an interstitial solution, wherein the weight ratio between the water and the polymeric matrix is up to 10, and wherein the concentration of rifaximin dissolved in the interstitial solution is between 0.5% and 30% by weight, wherein the biphasic material enhances dissolution of rifaximin in the interstitial solution to deliver an efficacious concentration of rifaximin to the mucosa at a site where the device is placed, without permeation of rifaximin through the mucosa to form a systemic concentration of rifaximin, and to avoid the intense red color of rifaximin at the site where the device is placed.