Patent ID: 6211160
Filing Date: 2001-04-03
Classification: A61K,A61P

Abstract:
A method for reducing an anti-adenovirus immune response in a mammalian subject to the administration of a live recombinant adenovirus carrying a transgene of interest, said method comprising:(a) administering to said mammal, via a route of administration which is either oral or intravenous, an inactivated adenovirus which has capsid proteins or expresses viral proteins that arc antigenically related to the capsid and viral proteins of said live recombinant adenovirus, said inactivated adenovirus being administered in an amount sufficient to reduce the anti-adenovirus immune response to said live recombinant adenovirus, and(b) administering to said mammal said live recombinant adenovirus,wherein said administering step (a) suppresses the immune response directed against said live recombinant adenovirus upon administering step (b).