Patent ID: 6756392
Filing Date: 2004-06-29
Classification: A61K,C07D

Abstract:
A compound of the formula (1): wherein;m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; R1 and R2 are each independently hydrogen, halo, cyano, (C1-C4)alkyl or (C1-C4)alkoxy; X is â€”Oâ€”, â€”Sâ€” or â€”NHâ€”; R3 is: (a) phenyl, naphthyl, heteroaryl or (C3-C8)cycloalkyl, each optionally substituted independently with 1 to 3 halo, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)thioalkyl, â€”C(&boxH;O)NH2, â€”C(&boxH;O)NH((C1-C4)alkyl), hydroxy, â€”Oâ€”C(&boxH;O)(C1-C4)alkyl, â€”C(&boxH;O)â€”Oâ€”(C1-C4)alkyl or hydroxy(C1-C4)alkyl; or (b) a bicyclic group of the following formula: â€ƒwhere the symbol â€œ*â€  in the definition of R3 indicates the point of attachment of each partial formula (1.1) through (1.4) to the remaining portion of formula (1); Y is â€ƒwhere the symbol â€œâ€  in the definition of Y indicates the point of attachment of each partial formula (1.5) through (1.11) to the remaining portions â€”NHâ€” of formula (I) and â€œ**â€  in the definition of V indicates the point of attachment of each partial formula (1.5) through (1.11) to the remaining portions â€”R4 of formula (1); and R4 is: (a) phenyl, naphthyl or heteroaryl, each optionally substituted independently with 1 to 3 carboxy, â€”C(&boxH;O)â€”Oâ€”(C1-C4)alkyl, halo, cyano, â€”C(&boxH;O)NH2, (C1-C4)alkyl, (C1-C4)alkoxy (C1-C4)haloalkyl, hydroxy or hydroxy(C1-C4)alkyl; or (b) (C1-C4alkyl optionally substituted with hydroxy, carboxyl, C(&boxH;O)â€”Oâ€”(C1-C4)alkyl, phenyl, naphthyl or heteroaryl wherein said phenyl, naphthyl and heteroaryl are each optionally substituted independently with 1 to 3 carboxy, â€”C(=O)O(C1-C4)alkyl, halo, cyano, â€”C(&boxH;O)NH2, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, hydroxy or hydroxy(C1-C4)alkyl; provided that the compounds wherein 1) m is different from 0 simultaneously with Y representing the partial formula (1.5) and R4 representing a non-substituted (C1-C4)alkyl are excluded; 2) m is equal to 0 simultaneously with Y representing the partial formula (1.5) and R4 representing a phenyl, a naphthyl or a heteroaryl each optionally substituted with 1 to 3 substituents independently selected from the proud consisting of carboxylic acid, halo, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, hydroxy and hydroxy(C1-C4)alkyl or R4 representing a (C1-C4)alkyl optionally substituted with a hydroxy, carboxylic acid, or a heteroaryl, which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of carboxylic acid, halo, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, hydroxy and hydroxy(C1-C4)alkyl are excluded; and 3) m is eaual to 0 sImultaneously with Y representing the partial formula (1.6) and R4 representing a phenyl or a naphtyl, each optionally substituted with 1 to 3 substituents independently selected from the group consisting of carboxylic acid, halo, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, hydroxy and hydroxy(C1-C4)alkyl are excluded; and provided that 2-(4-fluoro-phenoxy)-N-(4-methanesulfoxyamino-benzyl)-nicotinamide is excluded; or a pharmaceutically acceptable salt, thereof.