Patent ID: 8314121
Filing Date: 2012-11-20
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: X—Y represents NH—C(S), N═C—NR7R8, N═C—SR, N═C—R or N═C—OR; R1 represents a hydrogen atom, a cycloalkyl radical or an alkyl, heterocycloalkyl, aryl or heteroaryl radical, all these radicals being optionally substituted; R, which may be identical to or different from R1, is selected from the values of R1; R2 represents a hydrogen atom, a halogen atom or an alkyl radical; R3 represents a hydrogen atom, a halogen atom, a hydroxyl radical or an alkyl or alkoxy radical; R4 represents a hydrogen atom, a halogen atom or a cyano, CF3 or alkyl radical; R5 represents a hydrogen atom, a halogen atom, a hydroxyl, cyano, NR7R8, CONR7R8, NR11COR12 radical or optionally substituted cycloalkyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl radical; R6 represents a hydrogen atom, a halogen atom or an NR7R8, alkyl or alkoxy radical; R7 and R8 are such that: either R7 and R8, which may be identical or different, are such that one of R7 and R8 represents a hydrogen atom or an alkyl radical, optionally substituted; and the other one of R7 and R8 represents a hydrogen atom or a cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl radical, all these radicals being optionally substituted; or R7 and R8 form, together with the nitrogen atom to which they are attached, a cyclic radical formed from 3 to 7 ring members optionally containing one or more other heteroatoms selected from O, S or N, N being optionally substituted with R11, said cyclic radical itself being optionally substituted; all the alkyl, alkoxy, cycloalkyl, heterocycloalkyl, heteroaryl and aryl radicals, as well as the cyclic radical that R7 and R8 can form together with the nitrogen atom to which they are attached, indicated as optionally substituted, thus being optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl, cyano, nitro, CF3, NR9R10, NHCOR11, NHCO2R11, NHCONR9R10, NHSO2R13, COOH, COOalk, CONR9R10, SO2NR9R10, alkoxy, alkylthio, haloalkoxy, haloalkylthio, alkyl, fluoroalkyl, hydroxyalkyl, cycloalkyl, heterocycloalkyl, heteroaryl and phenyl radicals, these last-mentioned heteroaryl, aryl and phenyl radicals themselves being optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl, NH2, NH(alk), N(alk)2, alkyl, hydroxyalkyl and alkoxy radicals; R9 and R10 are such that: either R9 and R10, which may be identical or different, are such that one of R9 and R10 represents a hydrogen atom or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl and alkoxy radicals; and the other one of R9 and R10 represents a hydrogen atom or a cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl radical, all these radicals themselves being optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl, NH2, NH(alk), N(alk)2, alkyl, hydroxyalkyl and alkoxy radicals; or R9 and R10 form, together with the nitrogen atom to which they are attached, a cyclic radical formed from 3 to 7 ring members optionally containing one or more other heteroatoms selected from O, S or N, N being optionally substituted with R12, said cyclic radical itself being optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl, NH2, NH(alk), N(alk)2, alkyl, hydroxyalkyl and alkoxy radicals; R11 and R12, which may be identical or different, represent a hydrogen atom or an alkyl or phenyl radical, optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl and alkoxy radicals, the phenyl radical itself being optionally substituted with one or more alkyl radicals; R13 represents an alkyl or phenyl radical, optionally substituted with one or more radicals, which may be identical or different, selected from the halogen atoms and the hydroxyl and alkoxy radicals, the phenyl radical itself being optionally substituted with one or more alkyl radicals; all the above alkyl (alk) and alkoxy radicals being linear or branched and containing at most 12 carbon atoms; or a tautomer, racemate, enantiomer or diastereoisomer of the compound of formula (I), or an addition salt with an organic or inorganic acid or organic or inorganic base, of such compound of formula (I), tautomer, racemate, enantiomer or diastereoisomer; it being understood that the compounds of formula (I) in which all of the following conditions are fulfilled, are excluded: R2 represents hydrogen; R3 represents hydrogen or alkyl; X—Y represents N═C—NR7R8, or N═C—SR in which X represents N and Y represents ═C—NR7R8, or ═C—SR and R7, R8, and R are as defined above; or X—Y represents N═CR in which X represents N and Y represents ═CR and R represents aryl or heteroaryl; R1 represents H or alk; and R4, R5 and R6 are such that two of them represent H and the other one represents hydrogen, NH2 or NHalk or NR11COR12, wherein R11 represents a hydrogen atom and R12 represents an alkyl or a phenyl; or a tautomer, racemate, enantiomer or diastereoisomer of such excluded compounds of formula (I), or an addition salt with an organic or inorganic acid or organic or inorganic base, of such excluded compounds of formula (I), tautomer, racemate, enantiomer or diastereoisomer.