Patent ID: 8206707
Filing Date: 2012-06-26
Classification: A61K,A61P,C12N

Abstract:
1. A method for ameliorating wet type age-related macular degeneration, comprising administering to a mammal in need thereof: (a) a PDGF-B antagonist, wherein the PDGF-B antagonist is a pegylated aptamer having the sequence of SEQ ID NO: 23; and (b) a VEGF antagonist, wherein the VEGF antagonist is a humanized anti-VEGF antibody or binding fragment thereof that binds to VEGF-A, wherein the PDGF-B antagonist and the VEGF antagonist are administered simultaneously or within 90 days of each other, and wherein the PDGF-B antagonist and the VEGF antagonist are administered in an amount effective to ameliorate the wet type age-related macular degeneration, resulting in stable or improved vision in the mammal, and wherein the mammal is a human or mouse.