Patent ID: 6599942
Filing Date: 2003-07-29
Classification: A61P,C07C,C07D

Abstract:
A method of lowering Lp(a) levels in mammals which comprises administering to a mammal in need thereof an effective Lp(a) lowering amount of a compound of the formula in whichW is O, S, S(O) or S(O)2; X is â€”SR4, â€”S(O)R4, â€”S(O)2R4, or â€”S(O)2NR5R6; or X is â€”C(O)NR5R6 located at the 3â€²-, 4â€²- or 5â€² position; Y is O or H2; Z is hydrogen, halogen, hydroxy, optionally substituted alkoxy, aralkoxy, acyloxy or alkoxycarbonyloxy; R is hydrogen, halogen, trifluoromethyl, lower alkyl or cycloalkyl; R1 is hydroxy, optionally substituted alkoxy, aryloxy, heteroaryloxy, aralkoxy, cycloalkoxy, heteroaralkoxy or â€”NR5R6; R2 is hydrogen, halogen or alkyl; R3 is halogen or alkyl; R4 is optionally substituted alkyl, aryl, aralkyl, heteroaralkyl or heteroaryl; R5, R6 and R7 are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or R5 and R6 combined are alkylene optionally interrupted by O, S, S(O), S(O)2 or NR7 which together with the nitrogen atom to which they are attached form a 5- to 7-membered ring; n represents zero or an integer from 1 to 4; with the proviso that when X is â€”C(O)NR5R6, Z is different from hydrogen; or a pharmaceutically acceptable salt thereof.