Patent ID: 6566495
Filing Date: 2003-05-20
Classification: B01J,B82Y,C07B,C07C,C07D,C07H,C07K,C12Q,C40B,G01N,G03F,G11C,Y02P,Y10S

Abstract:
A method of electrically directed synthesis of a plurality of biological polymers on a surface of a substrate, comprising:a) providing a substrate having a surface with a plurality of localized areas, wherein each localized area comprises a molecule having a protected functional group is attached thereto; b) electrically activating a first set of one or more localized areas by applying an electric field or current to the first set of localized areas, thereby generating one or more activated groups in the first set of localized areas; c) selectively binding a first monomer having a protected functional group to an activated functional group in the first set of localized areas by reacting the first monomer with the molecule attached to the first set of localized areas; d) electrically activating a second set of one or more localized areas, said second set of localized areas containing the same, different or a combination of the same and different localized areas as in the first set of localized areas, by applying an electric field or current to the second set of localized areas, thereby generating one or more activated functional groups in the second set of localized areas; e) selectively binding a second monomer having a protected functional group to an activated functional group in the second set of localized areas by reacting the second monomer with the molecule attached to the second set of localized areas; and f) repeating (b)-(e) to synthesize a plurality of biological polymers on the surface of the substrate.