Patent ID: 6613777
Filing Date: 2003-09-02
Classification: A61P,C07D

Abstract:
A compound of the formula: or stereoisomer thereof or the pharmaceutically acceptable acid addition salt form thereof, whereinR1 is C1-6alkyl, NR5R6, OR6 or SR6; R2 is C1-6alkyl, C1-6alkyloxy, or C1-6alkylthio; R3 is Ar1 or Het1; R4 is hydrogen or C1-6alkyl; R5 is mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxy-C1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl or C1-6alkyloxyC1-6alkyl; R6 is mono- or di(C3-6cycloalkyl)methyl, Ar2C1-6alkyl, Ar2oxy-C1-6alkyl, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, tetrahydrofuranylmethyl, C1-6alkylthioC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, or C1-6alkylcarbonylC1-6alkyl; or R5 and R6 taken together with the nitrogen atom to which they are attached may form a pyrrolidinyl, piperidinyl, or homopiperidinyl, which pyrrolidinyl, piperidinyl, or homopiperidinyl, group is substituted with 1 or 2 substituents each independently selected from the group consisting of C1-6alkyl and C1-6alkyloxy-C1-6alkyl; or R5 and R6 taken together with the nitrogen atom to which they are attached may form a morpholinyl or a thiomorpholinyl group, said morpholinyl or thiomorpholinyl group may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of C1-6alkyl and C1-6alkyloxyC1-6alkyl; Ar1 is phenyl; naphthyl; or phenyl substituted with 1, 2 or 3 substituents each independently selected from the group consisting of halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyl, benzyloxy, C1-6alkylthio, nitro, amino and mono- or di(C1-6alkyl)amino; Het1 is pyridinyl; pyridinyl substituted with 1, 2 or 3 substituents each independently selected from the group consisting of halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino or mono- or di(C1-6alkyl)amino; and Ar2 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from the group consisting of halo, hydroxy, C1-6alkyl, C1-6alkyloxy, di(C1-6alkyl)aminoC1-6alkyl, or trifluoromethyl; or pyridinyl.