Patent ID: 7759366
Filing Date: 2010-07-20
Classification: A61P,C07D

Abstract:
1. A compound of the formula I in which R, R′ are each independently H, (C or R and R′ together with the carbon atom to which they are attached form a ring having from three to eight carbon atoms, wherein optionally one carbon atom is replaced by O, S(O) m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; p is 1, 2, 3, 4 or 5; q is 1, 2, 3 or 4; r is 2, 3, 4, 5 or 6; v is 0, 1, 2, 3 or 4; A, D, E, G, L are each independently C or N, where there is no corresponding R1, R2, R3, R4, R5 substituent when they are defined as N; R1, R2, R3, R4, R5 are each independently H, F, Cl, Br, I, CN, N wherein the alkyl, cycloalkyl, cycloalkenyl, bicycloalkyl, bicycloalkenyl and tricycloalkyl radicals are optionally substituted by fluorine atoms and wherein the aryl or heteroaryl radicals are optionally substituted by halogen, CN, (C R6, R7, R8, R9, R10 are each independently R11, NR17-bicyclic heterocycle, NR17-aryl, NR17-heteroaryl, wherein the aryl or heteroaryl radical is optionally fused to a 5- or 6-membered aromatic or nonaromatic carbon ring in which one or more CH or CH SO 2 —NH—CO—R12, SO 2 —NHR12, SO 2 —NH—(CH 2 ) r —OH, SO 2 —N[(C 1 -C 8 )-alkyl] 2 , SO 2 —NH—(CH 2 ) r —NH 2 , SF 5 , COOH, CO—NH 2 , (CH 2 ) q —CN, (CH 2 ) n —CO—NH—CN, (CH 2 ) n —CO—NH-piperidin-1-yl, (CH 2 ) n —CO—NH—SO 2 —NHR12, (CH 2 ) n —CO—NH—SO 2 —R18, (CH 2 ) n —CHO, (CH 2 ) n —C(═NH)—NH 2 , (CH 2 ) n —C(═NH)—NHOH, (CH 2 ) n —C(═NH)—[NH—O—(C 1 -C 6 )-alkyl], (CH 2 ) n —C(═NH)(R16), (CH 2 ) n —C(═NR13)NHR12, (CH 2 ) n —C(═NR12)NR12R13, (CH 2 ) n —C(═NH)O[(C 1 -C 6 )-alkyl], wherein the alkyl and cycloalkyl radicals are optionally substituted by fluorine atoms and wherein the aryl or heteroaryl radicals are optionally substituted by halogen, CN, (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, O—(C 1 -C 6 )-alkyl, S(O) m —(C 1 -C 6 )-alkyl, SO 2 —NH 2 , COOH, CONH 2 , CO—O(C 1 -C 6 )-alkyl, CO—(C 1 -C 6 )-alkyl and where the alkyl radicals are optionally substituted by F, Cl, Br, I, CN, N 3 , NC, NO 2 , CF 3 , (CH 2 ) n —O—R11, (CH 2 ) n —O—(CH 2 ) r —OH, (CH 2 ) n —O—CH(CH 2 OH) 2 , (CH 2 ) n —O—(CH 2 ) n —CO—O—(CH 2 ) r —NH 2 , (CH 2 ) n —O—(CH 2 ) n —CO—NH—(CH 2 ) r —OH, (CH 2 ) n —O-sugar, (CH 2 ) n —O-sugar acid, (CH 2 ) n —O-glucoside, (CH 2 ) n —O-galactoside, (CH 2 ) n —O-glucuronide, O—R13, OCF 3 , (CH 2 ) n —NH—R11, (CH 2 ) n —NH—R13, (CH 2 ) n —NH—CN, (CH 2 ) n —NH—SO 2 —R16, (CH 2 ) n —NH—(CH 2 ) n —SO 2 —R12, (CH 2 ) n —NR12-CO—R16, (CH 2 ) n —NR12-CO—NR12R13, (CH 2 ) n —NR12-CO—N(R12) 2 , (CH 2 ) n —NR12-CO—NHR11, (CH 2 ) n —NH—C(═NH)—NH 2 , (CH 2 ) n —NH—C(═NH)—R16, (CH 2 ) n —NH—C(═NH)—NHR12, (CH 2 ) n —NR12—C(═NR13)—NHR12, (CH 2 ) n —NR12—C(═NR12)—NR12R13, (CH 2 ) n —NH—(CH 2 ) n —CO—O—(CH 2 ) r —NH 2 , (CH 2 ) n —NH—(CH 2 ) n —CO—NH—[(C 1 -C 8 )-alkyl], (CH 2 ) n —NH—(CH 2 ) n —CO—NH—(CH 2 ) r —OH, (CH 2 ) n —NH—(CH 2 ) n —CO—N [(C 1 -C 8 )-alkyl] 2 , (CH 2 ) n —NH—(CH 2 ) n —CO—NH—[(C 3 -C 8 )-cycloalkyl], (CH 2 ) n —NH—(CH 2 ) n —CO—N[(C 3 -C 8 )-cycloalkyl] 2 , (CH 2 ) n —NH—C(CH 3 ) 2 —CO—O(C 1 -C 8 )-alkyl, (CH 2 ) n —NH—C(CH 3 ) 2 —CO—O(C 3 -C 8 )-cycloalkyl, (CH 2 ) n —NH—C(CH 3 ) 2 —CO—O—(CH 2 ) r —NH 2 , (CH 2 ) n —NH—C(CH 3 ) 2 —CO—O—(CH 2 ) n -aryl, (CH 2 ) n —NH—C(CH 3 ) 2 —CO—O—(CH 2 ) n -heteroaryl, (CH 2 ) n —NH—C(CH 3 ) 2 —CO—NH 2 , (CH 2 ) n —NH—C(CH 3 ) 2 —CO—NH—[(C 1 -C 8 )-alkyl], (CH 2 ) n —NH—C(CH 3 ) 2 —CO—NH—(CH 2 ) r —OH, (CH 2 ) n —NH—C(CH 3 ) 2 —CO—N[(C 1 -C 8 )-alkyl] 2 , (CH 2 ) n —NH—(CH 3 ) 2 —CO—NH—[(C 3 -C 8 )-cycloalkyl], (CH 2 ) n —NH—C(CH 3 ) 2 —CO—N[(C 3 -C 8 )-cycloalkyl] 2 , (CH 2 ) n —NH—C(CH 3 ) 2 —COOH, S(O) m —R12, SO 2 —R16, SO 2 N═CH—N(CH 3 ) 2 , SO 2 —NH—CO—R12, SO 2 —NHR12, SO 2 —NH—(CH 2 ) r —OH, SO 2 —N[(C 1 -C 8 )-alkyl] 2 , SO 2 —NH—(CH 2 ) r —NH 2 , SF 5 , COOH, CONH 2 , (CH 2 ) q —CN, (CH 2 ) n —CO—NH—CN, (CH 2 ) n —CO—NH-piperidin-1-yl, (CH 2 ) n —CO—NH—SO 2 —NHR12, (CH 2 ) n —CO—NH—SO 2 —R18, (CH 2 ) n —CHO, (CH 2 ) n —C(═NH)NH 2 , (CH 2 ) n —C(═NH)NHOH, (CH 2 ) n —C(═NH)(R16), (CH 2 ) n —C(═NR13)NHR12, (CH 2 ) n —C(═NR12)NR12R13, (CH 2 ) n —C(═NH)O[(C 1 -C 6 )-alkyl], where the alkyl and cycloalkyl radicals may be substituted by fluorine atoms and where the aryl or heteroaryl radicals may be substituted by halogen, CN, (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, O—(C 1 -C 6 )-alkyl, S(O) m —(C 1 -C 6 )-alkyl, SO 2 —NH 2 , COOH, CONH 2 , CO—[O(C 1 -C 6 )-alkyl], CO—(C 1 -C 6 )-alkyl and where the alkyl radicals may be substituted by fluorine atoms; wherein at least one of the R6, R7, R8, R9 and R10 radicals is always defined as NR17-aryl or NR17-bicyclic heterocycle or NR17-heteroaryl; wherein one of the four radical pairs of R6 and R7, or R7 and R8, or R8 and R9, or R9 and R10 optionally in each case together form the —CH R11 is H, (C R12 is H, (C R13 is H, SO R14 is H, (C R15 is H, (C R16 is aziridine-1-yl, azetidin-1-yl, 3-hydroxyazetidin-1-yl, piperidin-1-yl, 3-hydroxypiperidin-1-yl, 4-hydroxypiperidin-1-yl, 3-oxopiperidin-1-yl, 4-oxopiperidin-1-yl, pyrrolidin-1-yl, 3-pyrrolidinol-1-yl, 2-cyanopyrrolidin-1-yl, morpholin-N-yl, piperazin-1-yl, 4-[(C R17 is R18, R13, (CH R18 is (C R20 is H, (C R21 is H, F, CF R22 is H, CF or a physiologically compatible salt thereof.