Patent ID: 7432392
Filing Date: 2008-10-07
Classification: A61P,C07C,C07D

Abstract:
1. An ester compound of the formula (1): wherein R ring A is phenyl; X is —CON(R R R (wherein R (wherein R 0 is hydrogen and p is 0)); —(CH 2 ) q′ —N(R 13 )(R 14 ) (wherein R 13 and R 14 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkoxycarbonyl; or C 1 -C 6 acyl; or R 13 and R 14 taken together with the nitrogen atom to which they are attached may form (wherein p has the same meaning as defined above) and q′ is 0 or an integer of 1 to 3)); —CO—(R 15 ) (wherein R 15 is hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, optionally substituted C 6 -C 14 aryloxy or C 7 -C 16 aralkyloxy); or —(CH 2 ) r′ —O—CO—R 100′ (wherein R 100′ is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 12 alkoxyalkyl or —N(R 40 )(R 41 ) (wherein R 40 and R 41 are each independently hydrogen, C 1 -C 6 alkyl or optionally substituted C 6 -C 14 aryl, and r′ is 0 or an integer of 1 to 3)); ring B is Alk Alk l is 0 or an integer of 1 to 3; m is 0 or an integer of 1 to 3; ring C is R R E is —O— or —N(R Y is —O—CO—O—, —O—CO—, —CO—O—, —CO—O—C(R (wherein R 110 and R 111 are each independently hydrogen or C 1 -C 6 alkyl), provided that when Y is —CO—O—, then R 3 is —(CH 2 ) r′ —O—CO—R 100′ wherein R 100′ and r′ each has the same meaning as defined above; or a pharmaceutically acceptable salt thereof.