Patent ID: 8097749
Filing Date: 2012-01-17
Classification: C07F

Abstract:
1. A process for preparing a phosphoromonochloridite comprising, contacting an aromatic diol represented by the following formula: wherein: m is zero, 1, or 2; R optionally, R optionally, R with phosphorus trichloride (PCl 3 ) in a reaction solution in a reaction zone, which solution comprises greater than about 0.01 to less than 5 mole percent of a nitrogen base, calculated on moles of aromatic diol used, at a reaction temperature sufficient to produce the phosphoromonochloridite represented by the following formula: wherein m and R 1 through R 8 have the definitions given hereinabove, and sufficient to drive off HCl being produced from the reaction solution; wherein the contacting is carried out by adding a feed solution of the aromatic diol to the reaction zone comprising PCl 3 to form the reaction solution, the addition being at such a rate that the reaction temperature remains substantially isothermal, the feed solution comprising essentially all of the aromatic diol dissolved in a first organic solvent, and wherein the molar ratio of PCl 3 to aromatic diol dissolved in the reaction solution at any given time is greater than 10:1.