Patent ID: 7693664
Filing Date: 2010-04-06
Classification: G16B

Abstract:
1. A method of determining whether or not a test protein has thermostability, comprising the steps of: identifying (i) a thermostability index of the test protein based upon an amino acid sequence of the test protein and (ii) a thermostability index of a corresponding protein produced by a thermophilic microorganism selected from a plurality of thermophilic microorganisms, the corresponding protein being in an orthologous relationship with the test protein, wherein the proteins have amino acid sequences greater than 50 amino acids and are not predicted to contain two or more transmembrane domains; comparing the thermostability indices of the test protein and the corresponding protein; determining that the test protein has thermostability when the difference between the thermostability index of the test protein and the thermostability index of the corresponding protein falls within a predetermined range; and outputting the result of said determining step, wherein all steps are performed on a suitably programmed computer.