Patent ID: 8460669
Filing Date: 2013-06-11
Classification: A61K,A61P,C07K,G01N,Y02A

Abstract:
1. A method for reducing cytokine release from macrophages mediated by Japanese Encephalitis Virus (JEV) infection, comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition including an anti-human DVLR1/CLEC5A receptor antibody and a pharmaceutically acceptable carrier, wherein the anti-human DVLR1/CLEC5A antibody includes (i) the heavy chain variable sequence (VH) of SEQ ID NO:66 and the light chain variable sequence (VL) of SEQ ID NO:69; (ii) the VH sequence of SEQ ID NO:67 and the VL sequence of SEQ ID NO:70; or (iii) the VH sequence of SEQ ID NO:68 and the VL sequence of SEQ ID NO:71.