Patent ID: 6472426
Filing Date: 2002-10-29
Classification: A01N,A61K,C07C,C07D

Abstract:
A method of preparing a polyamine having the formula: Wherein:R1 and R2 are hydrocarbyl alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically acceptable acid, comprising 1) reacting a compound having the formula â€ƒwith a compound having the/ formula: Xâ€”(CH2)bâ€”X wherein Q is an amine protective group, X is a leaving group which can be displaced by the anion of compound (III), andR1, R2 and a, have the meanings ascribed above to produce a compound, of the formula: and2) deprotecting compound (W) to remove said Q groups to produce said polyamine.