Patent ID: 7858298
Filing Date: 2010-12-28
Classification: C07K,G01N

Abstract:
1. A method of inhibiting fusion of a CCR5+, CD4+ human cell by with a macrophage-tropic HIV-1, which comprises contacting the CCR5+, CD4+ cell with a non-chemokine agent which is a CCR5 chemokine receptor antagonist which (a) binds to the CCR5 chemokine receptor on the surface of the CCR5+, CD4+ cell; (b) competes with RANTES, MIP-1α and MIP-1β for binding to the CCR5 chemokine receptor on the surface of the CCR5+, CD4+ cell; (c) inhibits binding of HIV1 (d) inhibits fusion of HIV-1 (e) does not inhibit fusion of HIV-1 (f) does not activate an inflammatory response upon binding to the CCR5 chemokine receptor on the surface of the CCR5+, CD4+ cell; in an amount and under conditions such that fusion of the macrophage-tropic HIV-1 with the CCR5+, CD4+ cell is inhibited.