Patent ID: 7128927
Filing Date: 2006-10-31
Classification: A61K,Y02A

Abstract:
1. A composition for delivering a biologically active agent, comprising: an emulsion of a biologically active mixture and a controlled release formulation, the biologically active mixture consisting essentially of the biologically active agent and a pharmaceutically acceptable, aqueous medium as a protective carrier; and the controlled release formulation comprising a pharmaceutically acceptable, biodegradable thermoplastic polymer that is substantially insoluble in an aqueous or body fluid and a pharmaceutically acceptable organic solvent having a water solubility of from about 2 percent to about 20 percent by weight relative to a weight of a combination of organic solvent and water, and wherein the concentration of polymer in organic solvent ranges from about 0.5 gm per ml to about 3 gm per ml, the volume to volume ratio of the controlled release formulation to the biologically active mixture is about 1:1 to about 2:1, and the composition forms a solid implant in which the biologically active mixture is entrapped when the controlled release formulation contacts an aqueous medium or body fluid.