Patent ID: 6790458
Filing Date: 2004-09-14
Classification: A61K,A61Q

Abstract:
A pharmaceutical composition, comprising:(a) an active agent; and (b) a semi-solid delivery vehicle comprising: (i) a polyorthoester of formula I or formula II â€ƒwhere: R is a bond, â€”(CH2)aâ€”, or â€”(CH2)bâ€”Oâ€”(CH2)câ€”; where a is an integer of 1 to 10, and b and c are independently integers of 1 to 5; R* is a C1-4 alkyl; n is an integer of at least 5; and A is R1, R2, R3, or R4, where R1 is: â€ƒwhere: p is an integer of 1 to 20; R5 is hydrogen or C1-4 alkyl; and R6 is: â€ƒwhere: s is an integer of 0 to 30; t is an integer of 2 to 200; and R7 is hydrogen or C1-4 alkyl; R2 is: R3 is: â€ƒwhere: x is an integer of 0 to 30; y is an integer of 2 to 200; R8 is hydrogen or C1-4 alkyl; R9 and R10 are independently C1-12 alkylene; R11 is hydrogen or C1-6 alkyl and R12 is C1-6 alkyl; or R11 and R12 together are C3-10 alkylene; and R4 is a diol containing at least one functional group independently selected from amide, imide, urea, and urethane groups; â€ƒin which at least 0.1 mol percent of the A units are of the formula R1, and (ii) a pharmaceutically acceptable, polyorthoester-compatible liquid excipient selected from polyethylene glycol ether derivatives having a molecular weight between 200 and 4000, polyethylene glycol copolymers having a molecular weight between 400 and 4000, mono-, di-, or tri-glycerides of a C2-19 aliphatic carboxylic acid or a mixture of such acids, alkoxylated tetrahydrofurfuryl alcohols and their C1-4 alkyl ethers and C2-19 aliphatic carboxylic acid esters, and biocompatible oils.