Patent ID: 6229050
Filing Date: 2001-05-08
Classification: C07C,Y02P

Abstract:
A process for producing a hydroxyadamantanone derivative, said process comprising the step of allowing a 2-adamantanone derivative represented by the following formula (1): ##STR6##wherein each of R.sup.a, R.sup.b, and R.sup.c is, identical to or different from one another, a hydrogen atom, a halogen atom, an alkyl group, a hydroxyl group which may be protected by a protective group, a hydroxymethyl group which may be protected by a protective group, an amino group which may be protected by a protective group, a carboxyl group which may be protected by a protective group, or a nitro group, and of carbon atoms constituting an adamantane skeleton, the other carbon atoms than carbon atoms at bridgehead positions and at a bonding position of an oxo group may have a substituent, to react with oxygen in the presence of an imide compound represented by the following formula (2): ##STR7##wherein each of R.sup.1 and R.sup.2 is, identical to or different from each other, a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, where R.sup.1 and R.sup.2 may be combined to form a double bond or an aromatic or non-aromatic ring; X is an oxygen atom or a hydroxyl group; and one or two of N-substituted cyclic imido group indicated in the formula (2) may be further formed on said R.sup.1, R.sup.2, or on the double bond or aromatic or non-aromatic ring formed together by R.sup.1 and R.sup.2, a vanadium compound, and a manganese compound to yield a 5-hydroxy-2-adamantanone derivative represented by the following formula (3): ##STR8##wherein R.sup.a, R.sup.b, and R.sup.c have the same meanings as defined above.