Patent ID: 6586192
Filing Date: 2003-07-01
Classification: A01K,A61K,C07K,C12N

Abstract:
A method of obtaning a cell population enriched for long-term repopulating human hematopoietic stem cells (HSCs), the method comprising isolating hematopoietic cells from a human hematopoietic tissue and separating cells that express KDR on their surface (KDR+ cells) from cells that do not express KDR on their surface using a reagent selected from the group consisting ofi) an antibody that specifically binds with KDR, ii) a portion of an imrnunoglobilin, wherein the portion specifically binds with KDR, and iii) a conjugated vascular endothelial growth factor, thereby obtaining a KDR cell population that is enriched for long-term repopulating HSCS.