Patent ID: 6365180
Filing Date: 2002-04-02
Classification: A61K,A61P

Abstract:
A pharmaceutical composition comprising:one or more pharmaceutically active agent wherein said pharmaceutically a active agent is selected from the group consisting of said agents wherein at least one of said agents having at least one acid moiety, and at least one of said agents having at least one ester group or other chemically active moiety in which the terminal moiety to said ester group or other chemically active moiety is hydrolyzed or otherwise removed in situ or in vivo forming at least one acid moiety; and wherein said pharmaceutically active agent is soluble in acid at a ratio of about 3:1 (acid to solute) to about 10,000:1 (acid to solute) or a pharmaceutically acceptable salt thereof; at least one dispersing agent selected from the group consisting of polymer-based dispersing agents and carbohydratebased dispersing agents, wherein the ratio of said one or more pharmaceutically active agent to said at least one polymer-based dispersing agent is from about 3:1 (w/w) to about 1:50 (w/w) and wherein the ratio of said one or more pharmaceutically active agent to said at least one carbohydrate-based dispersing agent is from about 3:1 (w/w) to about 1:20 (w/w); and at least one solubilizing agent; and, optionally, at least one surfactant; and further optionally, at least one plasticizing agent.