Patent ID: 8835362
Filing Date: 2014-09-16
Classification: B01L,G01N

Abstract:
1. A method for determining an association of molecules with different structures, the method comprising: translocating the molecules partially or entirely through one or more nanochannels filled with an electrolyte solution based on an electric potential difference applied in a longitudinal direction of the one or more nanochannels; measuring one or more electrical signals through, across, or both through and across the one or more nanochannels for every event, the event being a translocation event, a binding event, or both the translocation event and the binding event; and determining that at least two different molecules have combined into a combination based on a change in the one or more electrical signals, a change in translocation time for the translocation event, or both a change in the one or more electrical signals and in the translocation time for the translocation event; wherein the proteins are G-protein coupled receptors.