Patent ID: 7709214
Filing Date: 2010-05-04
Classification: A61P,G01N

Abstract:
1. A method for upregulating an immune response, comprising contacting a PD-L2 polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2 or a cell expressing the polypeptide with a compound which binds to the polypeptide and downmodulates the interaction between the polypeptide and PD-1 in a sufficient concentration to downmodulate PD-1 mediated signaling by the polypeptide such that the immune response is upmodulated, wherein the compound is selected from the group consisting of: a blocking antibody that recognizes PD-L2, a combination of a blocking antibody that recognizes PD-L2 and a blocking antibody that recognizes PD-L1, a form of PD-L2 that does not activate PD-1, and a soluble form of PD-1.