Patent ID: 6024090
Filing Date: 2000-02-15
Classification: A61J,A61K,A61M

Abstract:
A method of treating a diabetic patient, comprising:(a) aerosolizing a formulation comprising monomeric insulin and a carrier to make an aerosol;(b) inhaling a volume of the aerosol into a patient's lungs, thereby obtaining a maximum monomeric insulin concentration (C.sub.MAX) for the patient in a time needed to obtain a maximum concentration (T.sub.MAX) for the patient wherein said C.sub.MAX and T.sub.MAX are less affected by an amount of air inhaled during inhalation of or after aerosolizing the formulation as compared to an effect on C.sub.MAX and T.sub.MAX obtained with a formulation of regular hexameric recombinant insulin;(c) measuring the patient's inspiratory flow rate and inspiratory volume; and (d) repeatedly aerosolizing the formulation at the same measured inspiratory flow rate and inspiratory volume as measured in step (c); and (e) maintaining serum glucose levels in the patient in a range of greater than 60 mg/dl and less than 125 mg/dl.