Patent ID: 6678556
Filing Date: 2004-01-13
Classification: A61N

Abstract:
A method for reducing inducement of histopathological change in a target muscle tissue site resulting from application of an electric field to a subject to deliver a therapeutic agent thereto, said method comprising:introducing an effective amount of at least one therapeutic agent into the target muscle tissue site of a subject; generating an electric field at the target muscle tissue site of the subject by introducing from 1 to about 4 monopolar DC pulses, each pulse having a duration of about 10 ms to about 100 ms, to generate a nominal field strength of about 100V/cm to about 300V/cm at the target muscle tissue site, thereby reducing the inducement of histopathological change in the target muscle tissue site resulting from application of the electric field as compared to alternative methods for applying an electric field to the target muscle tissue site.