Patent ID: 9045466
Filing Date: 2015-06-02
Classification: A61P,C07D

Abstract:
1. A compound represented by a formula (I): (wherein A R 8 and R 9 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, or R 8 and R 9 represent, together with the nitrogen atom bonded thereto, a saturated heterocyclic ring which may be substituted with oxo group; A R R 10 , R 13 , R 15 , R 16 , R 21 and R 22 are the same or different and represent a hydrogen atom, a C 1-6 alkyl group which may be substituted with 1 to 6 substituents selected from Substituent Group 1, a C 3-6 cycloalkyl group which may be substituted with 1 to 5 substituents selected from Substituent Group 1, an adamantyl group, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2 or a heterocyclic group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, R 11 represents a hydroxy group, a C 1-6 alkoxy group, a C 1-6 alkyl group which may be substituted with 1 to 6 substituents selected from Substituent Group 1, a C 3-6 cycloalkyl group which may be substituted with 1 to 5 substituents selected from Substituent Group 1, an adamantyl group, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, a heterocyclic group which may be substituted with 1 to 5 substituents selected from Substituent Group 2 or a group represented by a formula NR 23 R 24 , where R 23 and R 24 are the same or different and represent a hydrogen atom, a C 1-6 alkyl group which may be substituted with 1 to 6 substituents selected from Substituent Group 1 or a C 3-6 cycloalkyl group which may be substituted with 1 to 5 substituents selected from Substituent Group 1, R 12 , R 14 , R 17 and R 19 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, R 18 and R 20 are the same or different and represent a C 1-6 alkyl group which may be substituted with 1 to 6 substituents selected from Substituent Group 1, a C 3-6 cycloalkyl group which may be substituted with 1 to 5 substituents selected from Substituent Group 1, an adamantyl group, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2 or a heterocyclic group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, Substituent Group 1 is the group consisting of a halogen atom, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, a heterocyclic group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, a group represented by a formula —OR R 25 represents a hydrogen atom, a C 1-6 alkyl group, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2 or a C 1-6 alkanoyl group, R 29 represents a hydroxy group, a C 1-6 alkoxy group or a group represented by a formula NR 30 R 31 , where R 30 and R 31 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, or R 30 and R 31 represent, together with the nitrogen atom bonded thereto, a saturated heterocyclic ring which may be substituted with oxo group, R 27 and R 28 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, R 29 represents a C 1-6 alkyl group, a C 3-6 cycloalkyl group, an aryl group which may be substituted with 1 to 5 substituents selected from Substituent Group 2 or a heterocyclic group which may be substituted with 1 to 5 substituents selected from Substituent Group 2, Substituent Group 2 is the group consisting of a halogen atom, an oxo group, a hydroxy group, a C R 32 represents a hydroxy group, a C 1-6 alkoxy group or a group represented by a formula NR 33 R 34 , where R 33 and R 34 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, or R 33 and R 34 represent, together with the nitrogen atom bonded thereto, a saturated heterocyclic ring which may be substituted with oxo group; R R R 35 represents a hydroxy group, a C 1-6 alkoxy group or a group represented by a formula NR 36 R 37 , where R 36 and R 37 are the same or different and represent a hydrogen atom or a C 1-6 alkyl group, or R 36 and R 37 represent, together with the nitrogen atom bonded thereto, a saturated heterocyclic ring which may be substituted with oxo group, or R or a pharmaceutically acceptable salt thereof.