Patent ID: 7906493
Filing Date: 2011-03-15
Classification: A61K,A61P,C07H

Abstract:
1. A method of treatment of a condition associated with raised activity of the enzyme Core 2 GlcNAc-T comprising administration of an effective amount of a compound of the formula IV to a patient in need thereof: wherein Z is either a group of the formula VII: wherein: R R R R R R R R R R R R R R Y is O; or a group of the formula XI: wherein: R R R R R R R X is O or NH; or a pharmaceutically acceptable salt, ester or tautomeric form thereof; and wherein said condition associated with raised activity of the enzyme Core 2 GlcNAc-T is selected from the group consisting of an inflammatory disease, diabetic cardiomyopathy, myocardial dysfunction, cancer, cancer metastasis and diabetic retinopathy.