Patent ID: 6602508
Filing Date: 2003-08-05
Classification: A61K,A61P,C08B,Y10S

Abstract:
A method of immunizing a mammal against Group B Streptococcus (GBS) type II or type III infection comprising administering to a mammal an effective immunizing amount of a vaccine composition comprising a conjugate molecule comprising a Group B Streptococcus type II or type III polysaccharide fragment covalently bound to a protein, wherein the Group B Streptococcus type II or type LII polysaccharide fragment is obtained by a process comprising partial depolymerization by deamination, wherein the conjugate molecule has the structure wherein R1 is H and R2 is a sialylated heptasaccharide repeating-unit of formula â€ƒwherein n is about 5 to about 50 for the type II GBS polysaccharide fragment and wherein R1 is a sialylated pentasaccharide repeating-unit of formula wherein n is about 5 to 50 and R2 is disaccharide NeuAc(2-3)&bgr;-D-Galp1- for the type III GBS polysaccharide fragment.