Patent ID: 7247618
Filing Date: 2007-07-24
Classification: A61K,A61P,C12N

Abstract:
1. A method of inhibiting macrophage colony stimulating factor (M-CSF), the method comprising: providing a recombinant viral vector comprising a nucleic acid expressing antisense c-fms RNA; and administering the recombinant viral vector to a mammal in an amount effective to inhibit the M-CSF by an administration technique selected from the group consisting of intramural delivery, delivery with a nipple balloon catheter, periadventitial delivery, and inclusion in a coating on a stent that is implanted in the mammal, wherein the nucleic acid is constructed using at least one primer selected from the group consisting of a primer represented by SEQ ID NO:5, a primer represented by SEQ ID NO:6, and combinations thereof, and the nucleic acid corresponds to the ligand binding domain of a c-fms receptor.