Patent ID: 6762198
Filing Date: 2004-07-13
Classification: A61P,C07C,C07D

Abstract:
A compound having a structure according to Formula (I): wherein:(A) R3 is selected from hydrogen, and alkyl; (B) T is selected from hydrogen and hydroxy; (C) X1 and X2 are each independently selected from â€”Oâ€” or â€”Sâ€”; (D) M is â€”Eâ€”(CR19R19â€²)wR20 where (1) w is from 0 to 4; (2) E is selected from a â€”Oâ€”; â€”SOxâ€” where x is from 0 to 2; and â€”NR21â€” where R21 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, uryl, heteroaryl, cycloalkyl, and heterocycloalkyl, or R21 can join with R20 to form a ring with 5 to 8 members and 1 to 3 heteroatoms; (3) each R10 and R1â€² is hydrogen (4) R20 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; (E) Z is â€ƒwhere (a) Eâ€² and Y are â€”CHâ€”; (b) L is â€”C(R35)&boxH;(R35â€²)â€”, where R35 and R35â€² are each hydrogen; (c) c is 0; (d) Aâ€² is selected from covalent bond, â€”Oâ€” and â€”Sâ€”; and (e) Tâ€² is â€”(CR37R37â€²)câ€”R38 where c is 0; and R38 is selected from hydrogen, alkyl, alkenyl, alkynyl, halogen, heteroalkyl, haloalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; or an optical isomer, diastereomer or enantlomer for Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.