Patent ID: 6849738
Filing Date: 2005-02-01
Classification: C07D

Abstract:
1. A process for producing a compound represented by the formula(XII): wherein respective symbols have the same meanings as those described below, which comprises: subjecting a compound represented by the formula(I wherein R 1a denotes nitro, phthalimido, mono(alkylcarbonyl)amino or di(alkylcarbonyl)amino, or a salt thereof, to an acid halogenating reaction, which is successively reacted with malonic acid ester and magnesium alkoxide and, thereafter, treated with an acid and, then, reacted with a sulfur and a compound represented by the formula(II): wherein R 2 denotes alkyl or aryl, or a salt thereof in the presence of primary amine, to obtain a compound represented by the formula (III): wherein respective symbols have the same meanings as those described above, or a salt thereof and, then, reacting the compound (III) or a salt thereof with a compound represented by the formula(IV): wherein R 3 denotes alkyl optionally having a substituent or aryl optionally having a substituent, or a salt thereof, to obtain a compound represented by the formula (V): wherein respective symbols have the same meanings as those described above, or a salt thereof and, then, subjecting the compound (V) or a salt thereof to a ring closing reaction, which is reacted with a compound represented by the formula(VI): wherein R 4 denotes a leaving group, and R 5 denotes aryl optionally having a substituent, or a salt thereof, to obtain a compound represented by the formula (VII): wherein respective symbols have the same meanings as those described above, or a salt thereof and, then, subjecting the compound (VII) or a salt thereof to a brominating reaction, which is successively reacted with a compound represented by the formula (VIII): wherein R 6 and R 7 denote alkyl optionally having a substituent, aryl optionally having a substituent, alkoxy optionally having a substitutent, aralkyl optionally having a substituent or a heterocycle group optionally having a substituent, or a salt thereof, to obtain a compound represented by the formula (IX): wherein respective symbols have the same meanings as those described above, or a salt thereof, and (1) when R (2) when R (3) when R to obtain a compound represented by the formula (X): wherein respective symbols have the same meanings as those described above, or a salt thereof and, then, (i) reacting the compound (X) or a salt thereof, with halogenoformic acid ester and a compound represented by the formula (XI): wherein R 8 and R 9 denote a hydrogen atom, alkoxy optionally having a substituent or alkyl optionally having a substituent, or a salt thereof, or (ii) reacting the compound (X) or a salt thereof with carbonyldiimidazole and a compound represented by the formula (XI): wherein respective symbols have the same meanings as those described above or a salt thereof.