Patent ID: 6818771
Filing Date: 2004-11-16
Classification: C07D

Abstract:
A process for the production of 7-(3-aminomethyl-4-syn-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate sesquihydrate which comprises: (a) forming a crystallization solution comprising 7-(3-aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid, and a solvent comprising at least one least one water miscible cosolvent and water, wherein the ratio of water miscible cosolvent:water is in the range of 2:1 to 1:2 v/v,(b) reacting said carboxylic acid and methanesulfonic acid in the solvent, and (c) isolating the resulting solid product which comprises 7-(3-aminomethyl-4-syn-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate sesquihydrate.