Patent ID: 6114549
Filing Date: 2000-09-05
Classification: C07D

Abstract:
A process for the preparation of compounds of the Formula (19): ##STR46## wherein three of A, B, C and D are carbon atoms and one is a nitrogen atom;R.sup.1 is ##STR47## where R.sup.3 and R.sup.4 are independently H, OH, protected OH, C.sub.1-8 alkoxy, Br, F, I, Cl, CF.sub.3 or C.sub.1-6 alkyl and R.sup.5 is --OCH.sub.2 CH.sub.2 OH;R.sup.2 is ##STR48## where R.sup.3 and R.sup.4 are as indicated above and Z is H, OH, or C.sub.1-5 alkoxy;or a pharmaceutically acceptable salt thereof, which comprises the steps of(1) treating the compound of Formula (12): ##STR49## where A, B, C, D, R.sup.3 and R.sup.4 are as described above; and R is H, OH, C.sub.1-5 alkoxy or a protected oxy group, with potassium carbonate and methanol to form compounds of formula (14): ##STR50## where A, B, C, D, R, R.sup.3 and R.sup.4 are as described above; (2) alkylation of the product of step (1), followed by saponification then treatment with ethylene diamine to form the product of Formula (1) above as the ethylene diamine salt (2:1).