Patent ID: 6262046
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR59##and pharmaceutically-acceptable salts thereof,whereinA is CO, SO.sub.2 or CH.sub.2 ;Ar.sup.1 is phenyl optionally substituted by one or more substituents independently selected from halogen, C.sub.1-6 alkoxy optionally substituted by one or more halogen, and C.sub.1-6 alkyl optionally substituted by one or more halogen;X.sup.1 is C.sub.3-7 cycloalkyl, aryl or C.sub.1-6 alkyl,said C.sub.1-6 alkyl being optionally substituted by fluoro, CO.sub.2 H, CO.sub.2 (C.sub.1-4 alkyl), C.sub.3-7 cycloalkyl, adamantyl, aryl or het,and said C.sub.3-7 cycloalkyl being optionally substituted by 1 or 2 substituents each independently selected from C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.1-4 alkoxy, OH, F, fluoro(C.sub.1-4 alkyl) and fluoro(C.sub.1-4 alkoxy);X is a direct link or NR.sup.1 ;R is SO.sub.2 aryl, SO.sub.2 (C.sub.1-6 alkyl optionally substituted by one or more halogen), ##STR60##R.sup.1 is H, C.sub.1-6 alkyl optionally substituted by one or more halogen,or R.sup.1 is phenyl optionally substituted by one or more substituents independently selected from halogen, C.sub.1-6 alkoxy optionally substituted by one or more halogen, or C.sub.1-6 alkyl optionally substituted by one or more halogen;Y is O, NCO(C.sub.1-6 alkyl optionally substituted by one or more halogen), NCO.sub.2 (C.sub.1-6 alkyl optionally substituted by one or more halogen), NSO.sub.2 (C.sub.1-6 alkyl optionally substituted by one or more halogen), NCOaryl, NCO.sub.2 aryl, NSO.sub.2 aryl, NSO.sub.2 (C.sub.1-6 alkyl optionally substituted by one or more halogen), CH.sub.2, CHF, CF.sub.2, NH, NCH.sub.2 aryl, N(C.sub.1-6 alkyl optionally substituted by one or more halogen), or NCH.sub.2 (C.sub.3-7 cycloalkyl);with the proviso that X is not NR.sup.1 when R is ##STR61##wherein ""aryl"" used in all the above definitions represents phenyl or naphthyl optionally substituted with one or more substituents independently selected from halogen, C.sub.1-6 alkoxy optionally substituted by one or more halogen, or C.sub.1-6 alkyl optionally substituted by one or more halogen;and ""het"" used in the definition of X.sup.1 means thienyl or a 5- or 6-membered ring heteroaryl group containing either 1 or 2 nitrogen heteroatoms or 1 nitrogen heteroatom and one oxygen or sulphur heteroatom, each optionally substituted by 1 or 2 substituents each independently selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, fluoro(C.sub.1-4 alkyl) and fluoro(C.sub.1-4 alkoxy).