Patent ID: 6436964
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:X is O, S, NR, S(&boxH;O), or S(&boxH;O)2; Y is â€”C(&boxH;O)â€”, â€”CH(OH)â€”, â€”CH2â€”, â€”C(&boxH;NOR), CHNR7R, S, SO, or SO2; ------- represents a single or a double bond; n is 1, 2, 3 or 4; R is H or C1-C6 alkyl; R1a, R1b, R1c and R2 are each independently H, F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, â€”NR7R8, â€”C(&boxH;O)NR7R8, â€”NR7C(&boxH;O)R8, CN or phenyl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; R3 is H, OH, hydroxy(C1-C6)alkyl, C1-C6 alkyl, C1-C6 alkoxy, or (C1-C6)alkylthio; R4 is aryl, pyridyl, C3-C8 cycloalkyl, aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; or pyridyl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; R5 is aryl, pyridyl, C3-C8 cycloalkyl, aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; or pyridyl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; R6a and R6b are each independently H or C1-C3 alkyl; R7 and R8 are each independently H, C1-C6 alkyl, aryl or aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, (C1-C6)alkylthio, phenyl, NO2, NH2, or CN; and the pharmaceutically acceptable salts thereof.