Patent ID: 8372985
Filing Date: 2013-02-12
Classification: C07C,C07D

Abstract:
1. A process of making an enantioenriched α-aminooxyaldehyde comprising reacting an aldehyde of formula (I): with a nitroso compound of formula (IIIa) or (IIIb): in the presence of a solvent and a catalyst of formula (IVa): wherein: R represents hydrogen; a substituted or unsubstituted alkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted alkoxycarbonyl group; a substituted or unsubstituted aryl group; or R n is an integer from 0-5; R the configuration of the stereogenic carbon alpha to the nitrogen on the pyrolidine ring is the (L) or optionally (D) configuration.