Patent ID: 6753327
Filing Date: 2004-06-22
Classification: A61K,A61P,C07C,C07D

Abstract:
An amide of the formula I and its tautomeric forms, enantiomeric and diastereomeric forms, E and Z forms, and physiologically tolerated salts, in which the variables have the following meanings:A â€”(CH2)pâ€”R1, where R1 is pyrrolidine, morpholine, hexahydroazepine â€ƒpiperidine, or â€”NR5R6 where the cyclic amines are optionally be substituted by one or two R15 radicals, and R15 hydrogen, C1-C6-alkyl, Oâ€”C1-C6-alkyl or phenyl, and R5, R6 and R7 are, independently of one another, hydrogen, C1-C4-alkyl, cyclohexyl, cyclopentyl, CH2Ph, Ph, or CH2CH2Ph, where the phenyl rings are optionally substituted by R6, and p can be 1 or 2 and B is phenyl, pyridyl, pyrazyl, pyrimidyl or pyridazyl which are optionally substituted by up to 2 R8 radicals, and A and B together are also â€ƒand R16 is hyrogen, C1-C6-alkyl or (CH2)1-4-phenyl, where the phenyl ring is optionally substituted by a maximum of 2 R6 radicals, and D can be a bond, â€”(CH2)0-2â€”Oâ€”(CH2)0-2, â€”(CH2)mâ€”, â€”CH&boxH;CHâ€”, â€”Câ‰¡C, and R2 is chlorine, bromine, flourine, C1-C6-alkyl, NHCOâ€”C1-C4-alkyl, NHSO2â€”C1-C4-alkyl, NO2, â€”Oâ€”C1-C4-alkyl or NH2, and R3 is â€”C1-C6-alkyl, branched or unbranched, which is optionally substituted with a SCH3 radical, phenyl ring, imidazolyl ring, indolyl ring, cyclopentyl ring, cycloheptyl ring or cyclohexyl ring which is in turn substituted by a maximum of two R8 radicals, where R8 is hydrogen, C1-C4-alkyl, branched or unbranched, â€”Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, NHCOâ€”C1-C4-alkyl, â€”NHSO2â€”C1-C4-alkyl or â€”SO2â€”C1-C4-alkyl; and Y is phenyl and R4 is hydrogen, COOR9 or COâ€”Z in which Z is NR10R11, R9 is hydrogen or C1-C6-alkyl, linear or branched, which is optionally substituted by a phenyl ring which is optionally substituted by one or two R12 radicals, and R10 is hydrogen; C1-C6-alkyl; linear or branched, which is optionally substituted by a phenyl ring which is optionally substituted by one or two R12 radicals, R11 is hydrogen or C1-C6 alkyl, branched or unbranched, which is optionally substituted by a phenyl ring which is optionally substituted by an R9 radical, and R12 can be is hydrogen, C1-C4-alkyl, branched or unbranched, â€”Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, â€”NHCOâ€”C1-C4-alkyl, â€”NHCO-phenyl, â€”NHSO2â€”C1-C4-alkyl, NHSO2-phenyl, â€”SO2â€”C1-C4-alkyl or â€”SO2-phenyl, and R13 is hydrogen or C1-C6-alkyl, linear or branched, which is optionally substituted by a phenyl ring which is optionally substituted by one or two R12 radicals, and R14 is hydrogen or C1-C6-alkyl, linear or branched, which is optionally substituted by a phenyl ring which is optionally substituted by one or two R12 radicals, and n is a number 0, 1 or 2, and m and q are, independently of one another, a number 0, 1, 2, 3 or 4.