Patent ID: 8987244
Filing Date: 2015-03-24
Classification: A61K,A61P

Abstract:
1. A method of treating tissue damage relating to copper values content in a mammal, said tissue being selected from myocardial tissue, kidney tissue, eye tissue, nerve tissue, and vascular tissue, the method comprising administering to said mammal in need thereof, an amount of an agent or agents effective to lower the copper (II) values content in one or more of said tissues and thereby treat said damage, wherein said mammal does not have Wilson's Disease or diabetes mellitus, and wherein the agent(s) is (are) selected from the group consisting of: trientine; ethylenediaminetetraacetic acid (EDTA); diethylenetriaminetetraacetic acid (DPTA); 2,2,2 tetramine tetrahydrochloride (TETA); 2,3,2 tetramine tetrahydrochloride; 5,7,7′12,14,14′hexaxmethyl-1,4,8,11 tetraazacyclotretradecane (Cyclam S); 3-7-Diazanonan-1,9-diamin (BE 6184); 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid; 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane; 4,11-bis(N,N-diethyl-amidomethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane; 4,11-bis(amidoethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane; melatonin; N,N′-diethyldithiocarbamate; bathocuproinedisulfonic acid; bathocuprinedisulfonate; trimetazidine; triethylene tetramine tetrahydrochloride; 2,3,2-tetraamine; 1,10-orthophenanthroline; 3,4-Dihydroxybenzoic acid; 2,2′-bicinchinonic acid; diamsar; 3,4′,5, trihydroxystilbene (resveratrol); mercaptodextran; o-phenanthroline; disulfiram (antabuse); sar; diethylene triamine pentaacetic acid; and calcium trisodium diethylenetriaminepentaacetate.