Patent ID: 6090802
Filing Date: 2000-07-18
Classification: A61P,C07D

Abstract:
A 1-methylcarbapenem compound of the formula (I): ##STR464## wherein: R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.2 represents a hydrogen atom or an ester residue which can be hydrolyzed in vivo, andA represents a group of the formula (A1) ##STR465## wherein, in the formula (A1): n stands for 0, 1 or 2,p stands for 0, 1 or 2,R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group, andR.sup.4 represents a group of the formula (Q2) ##STR466## B represents a phenylene, phenylene(C.sub.1 -C.sub.3)alkyl, cyclohexylene, cyclohexylene(C.sub.1 -C.sub.3)alkyl or a C.sub.1-5 alkylene group which is unsubstituted or substituted by one to three substituents which are the same or different from each other and each represents an amino, hydroxyl, cyclohexyl(C.sub.1 -C.sub.3)alkyl, C.sub.1-4 alkyl, phenyl or benzyl group,R.sup.7 represents a hydrogen atom or a C.sub.1-4 alkyl group, andR.sup.14 represents a group of the formula --C(.dbd.NH)R.sup.8, wherein R.sup.8 represents a hydrogen atom, a C.sub.1-4 alkyl group or a group of the formula --NR.sup.9 R.sup.10, in which R.sup.9 and R.sup.10 are the same as or different from each other and each represents a hydrogen atom or a C.sub.1-4 alkyl group;or a pharmacologically acceptable salt thereof.