Patent ID: 6316405
Filing Date: 2001-11-13
Classification: A61K,A61P,C07K

Abstract:
Compounds of formula A-Z, wherein A is selected from the group consisting of ##STR45##wherein R is a C.sub.2 to C.sub.6 alkylcarboxy group (--(CH.sub.2).sub.1-5 C(.dbd.O)O--);V is a MeLeu(3-OH), MeLeu, MeSer, MeSer-PG, MeThr, or MeThr-PG residue;W is a (D)-N-methyl-amino acid or an N-methylglycidyl residue;X and X' are independently an N-methyl-leucinyl or an N-methylalanyl residue;Y is a lysyl, homo-lysyl, ornithinyl, lysyl-PG, homo-lysyl-PG, or ornithinyl-PG residue;wherein each PG is, independently, a side-chain protecting group; andZ is a polypeptide comprising 5 or more contiguous residues of A.beta. peptide; and salts thereof.