Patent ID: 8278315
Filing Date: 2012-10-02
Classification: A61K

Abstract:
1. A method for preferential disruption of malfunctioning cells in a living mammal, which comprises: (a) administering a compound which associates with DNA in cells of said mammal, said compound comprising a pre-selected element selected from the group consisting of Pt, Ca, Ti, Br, I, Gd, Y and Ru; and then (b) irradiating a selected region, in which malfunctioning cells having said compound associated with DNA are located, with line emission x-rays from an X-ray tube, said line emission X-rays being of an energy selected to cause emission of Auger electrons from said pre-selected element of said compound in a dose effective to disrupt DNA proximate to the irradiated pre-selected element, said dose for each activation of said X-ray tube being at least about 10