Patent ID: 6518310
Filing Date: 2003-02-11
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:R1 is one of C3-8alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl, any of which may be optionally substituted; Z is â€”NR10COâ€”or â€”CONR10â€”; R2, R3 and R4 are each independently one of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamido, â€”CO2Rx, â€”CH2ORx or â€”ORx, or when present on adjacent carbon atoms, R2 and R3 may also be taken together to form one of â€”CH&boxH;CHâ€”CH&boxH;CHâ€” or â€”(CH2)qâ€”, where q is from 2 to 6, and R4 is defined as above; Rx, in each instance, is independently one of hydrogen, alkyl or cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations; Y is one of â€”Oâ€”, â€”NR10â€”, â€”Sâ€”, â€”CHR10â€” or a covalent bond; X is oxygen or NR9; R9 is one of hydrogen, alkyl, cycloalkyl or aryl, wherein said alkyl, cycloalkyl or aryl can be optionally substituted with amino, monoalkylamino, dialkylamino, alkoxy, hydroxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, aryl, heteroaryl, acylamino, cyano or trifluoromethyl; R6 is one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C2-10)alkyl, dialkylamino(C2-10)alkyl or carboxyalkyl; R7, R8, R11 and R12 are each independently one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or carboxyalkyl; or R7 and R8 are taken together to form â€”(CH2)yâ€” where y is zero (a bond), 1 or 2, while R11 and R12 are defined as above; or R7 and R12 are taken together to form â€”(CH2)qâ€” where q is zero (a bond), or 1 to 8, while R8 and R11 are defined as above; or R8 and R11 are taken together to form â€”(CH2)râ€”, where r is 2-8, while R7 and R12 are defined as above; R10, in each instance, is independently one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C2-10)alkyl, dialkylamino(C2-10)alkyl or carboxyalkyl; Ra, Rb and Rc are independently hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano orâ€”CO2Rw; Rw is alkyl, cycloalkyl, phenyl, benzyl, â€ƒwhere Rd and Re are independently hydrogen, C1-6alkyl, C2-6alkenyl or phenyl, Rf is hydrogen, C1-6alkyl, C2-6alkenyl or phenyl, Rg is hydrogen, C1-6alkyl, C2-6alkenyl or phenyl, and Rh is aralkyl or C1-6alkyl; n is from zero to 8; and m is from zero to 4.