Patent ID: 6015825
Filing Date: 2000-01-18
Classification: A61K,A61P,B82Y,C07D

Abstract:
A compound of formula (I) ##STR209## or a pharmaceutically acceptable salt thereof, wherein: Ar is phenyl substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;Z is H or F; and,Het is pyrazolyl optionally substituted by 1 to 3 substituents each independently selected from halo, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.4 alkoxy)methyl, 2-(C.sub.1 -C.sub.4 alkoxy)ethoxymethyl, 2-hydroxyethoxymethyl, cyanomethyl, phenylthio, phenyl-substituted C.sub.1 -C.sub.2 alkyl, --NHC(O)(C.sub.1 -C.sub.4 alkyl), --NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl), --S(O).sub.n (C.sub.1 -C.sub.4 alkyl) where n is an integer from 0 to 2, --NHC(O)NR.sup.1 R.sup.2, --NR.sup.1 R.sup.2 and --CH.sub.2 C(O)NR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.4 alkyl, and the phenyl groups of the foregoing Het groups are optionally substituted by halo, trifluoromethyl, or C.sub.1 -C.sub.4 alkyl.