Patent ID: 8932460
Filing Date: 2015-01-13
Classification: B01D,G01N

Abstract:
1. A preparative separation/purification system for passing a solution containing a target component through a trap column to capture the target component in the trap column and then passing a solvent having an elution capability through the trap column to elute the target component from the trap column and collect the target component, comprising: a) a holding means for holding the trap column to extend an internal passage of the trap column vertically with an inlet end thereof directed downwards and a discharge end thereof directed upwards; b) a liquid supply means for supplying a second solvent to the inlet end of the trap column, with the target component captured in the trap column held by the holding means, the second solvent having a low solubility to a first solvent remaining in the trap column and having a specific gravity greater than a specific gravity of the first solvent; c) a passage selection means for changing a passage configuration to selectively send a solution exiting from the discharge end of the trap column to either a collection passage leading to a collection container or a disposal passage leading to a disposal port; d) a passage control means for controlling the passage selection means to send the first solvent extruded from the discharge end of the trap column by a push of the second solvent to the disposal passage according to the action of supplying the second solvent to the trap column by the liquid supply means, and to send the solution with the second solvent contained therein to the collection passage at a timing when the solution exits from the discharge end of the trap column; and e) a flow rate control means for controlling the liquid supply means to supply the second solvent at a first supply flow rate when the first solvent is sent to the disposal passage from the discharge end of the trap column, and to supply the second solvent at a second supply flow rate which is lower than the first supply flow rate when the solution with the second solvent contained therein is sent to the collection passage from the discharge end of the trap column; wherein the passage control means is further configured to control the passage selection means to send an emulsion containing the target component in the second solvent, to the collection passage from the discharge end of the trap column.