Patent ID: 6576760
Filing Date: 2003-06-10
Classification: C07F

Abstract:
A process for the manufacture of a cyclic compound having the formula in which:R1, R3, and R5 are methylenephosphonate esters of the formula â€ƒin which R11 and R12 are members independently selected from the group consisting of alkyl and aryl, R2 and R4 are members independently selected from the group consisting of unsubstituted and substituted divalent alkyl, divalent aryl, divalent alkylaryl, and divalent alkylarylalkyl groups, R6 is a member selected from the group consisting of unsubstituted and substituted divalent alkyl, divalent aryl, divalent alkylaryl, and divalent alkylarylalkyl groups, and n is 0, 1, 2, 3, 4, 5 or 6, said process comprising:(a) reacting a compound having the formula â€ƒwith a tri-substituted phosphite of the formula in which R13 is a member selected from the group consisting of alkyl and aryl, p2 and a source of formaldehyde in the presence of water, to yield a substituted polyamine having the formula and(b) reacting said substituted polyamine with a bridging agent which contains leaving groups capable of participating in a nucleophilic reaction with the NH groups of said starting compound of Formula II to yield the R6 bridge of said cyclic compound of Formula I.