Patent ID: 6207404
Filing Date: 2001-03-27
Classification: C07D,C12Q,Y10S

Abstract:
A compound of the Formula I: ##STR6##(a) wherein R1 is an aryl containing an aryl ring carbon and/or an aryl ring nitrogen and the (CH.sub.2)n is coupled via a covalent bond to the aryl ring carbon or the aryl ring nitrogen;(b) wherein n is 0, 1, 2, or 3;(c) wherein R2 is selected from the group consisting of an hydrido, CN, CH.sub.3, sulfomethyl, and a haloalkyl having 1-18 carbons;(d) wherein R3 is selected from the group consisting of an hydrido, CN, and an aryl containing an aryl ring carbon and/or an aryl ring nitrogen, provided that R2 and R3 are not both hydrido, and wherein the aryl group is coupled directly to the coumarin ring via a covalent bond between the coumarin ring carbon and the aryl ring carbon or the aryl ring nitrogen;(e) wherein when R1 is phenyl and n is 1, R2 is not an hydrido when R3 is phenyl and R3 is not an hydrido when R2 is CH.sub.3 ;(f) wherein the compound is a cytochrome P450 substrate.