Patent ID: 7524819
Filing Date: 2009-04-28
Classification: A61K,A61P,C07K

Abstract:
1. A method for counteracting toxic levels of reactive oxygen species and other free radicals in cells and tissues, the method comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a composition comprising (a) at least one purified peptide compound or a pharmaceutically acceptable salt of the at least one purified peptide compound, wherein the at least one purified peptide compound of the composition is a terminal-amino-capped, a terminal-carboxy-capped or a terminal-amino-capped and a terminal-carboxy-capped amino acid sequence, wherein the amino acid sequence is: Asp Gly Asp, Asp Gly, Thr Val Ser, Glu Ala, [Lip]-Asp Gly Asp Gly Asp ([Lip]-SEQ ID NO: 4), or [Lip]-Asp Gly Asp Gly Asp Phe Ala ([Lip]-SEQ ID NO: 6) wherein the amino-terminal capping group is 1 to 6 lysine residues; a glucose-3-O-glycolic acid group; an acyl group containing a hydrocarbon chain from 1 to 25 carbon atoms in length; an acetyl group; a palmitoyl group; a lipoic acid group [Lip]; a docosahexaenoic acid group; or combinations thereof, and wherein the carboxy-terminal capping group is an amino group linked to the carboxy terminal carbonyl of the peptide compound amino acid sequence via an amide linkage; and (b) a pharmaceutically acceptable carrier.