Patent ID: 6376205
Filing Date: 2002-04-23
Classification: A61K,A61P,C07K,G01N

Abstract:
A method of screening for an agent that modulates or inhibits tau-tau association comprisinga) contacting a tau protein or a derivative thereof comprising a tau core fragment and which is bound to a solid phase with i) an agent suspected of being capable of modulating or inhibiting tau-tau association and ii) a material selected from the group consisting of a labelled tau protein, a labelled tau protein derivative, a tau protein which is immunologically distinguishable from the bound tau protein and the bound tau protein derivative, and a tau protein derivative which is immunologically distinguishable from the bound tau protein and the bound tau protein derivative, wherein said material is capable of binding to the bound tau protein or the bound tau protein derivative, to provide tau-tau binding, and b) detecting the tau-tau binding, wherein a decrease in said binding as compared to tau-tau binding in the absence of said agent indicates that the agent modulates or inhibits tau-tau association.