Patent ID: 9138405
Filing Date: 2015-09-22
Classification: A61K,A61L,A61P

Abstract:
1. A sterile, injectable and viscoelastic aqueous gel for injection into intra-articular spaces of a subject, comprising: hyaluronic acid or a salt thereof at a concentration of 10-25 mg/ml, the hyaluronic acid being non-cross-linked and having a molecular weight of 2×10 one or more polyols selected from the group consisting of propylene glycol, sorbitol, mannitol, and mixtures thereof, at a concentration of 10-45 mg/ml; and a physiologically acceptable buffer, wherein, the gel has been moist heat sterilized, the gel is injectable into the intra-articular space of a subject, and the gel has a crossover frequency point between an elastic modulus G′ and a viscous modulus G″ in a range of greater than zero to 0.82 Hz, and G′ is greater than G″ at the frequencies higher than the crossover frequency point.