Patent ID: 6617306
Filing Date: 2003-09-09
Classification: A61K,A61P

Abstract:
A carrier for in-vivo delivery of a therapeutic agent comprising a thiol group, wherein said carrier comprises:a) a polymer selected from the group consisting of carboxymethylcellulose, dextran, polyvinyl alcohol, polyvinyl pyrrolidone, poly-1,3-dioxolane, poly-1,3,6-trioxane, amino acid homopolymers, amino acid copolymers, polypropylene glycol, copolymers of ethylene glycol/propylene glycol, ethylene/maleic anhydride copolymer, copolymer of polyethylene glycol and an amino acid, polypropylene oxide/ethylene oxide copolymers, polyethylene glyco/thiomalic acid copolymers and unbranched polyethylene glycol; b) multiple thiol compounds each comprising a sulfur atom conjugated to said polymer such that said sulfur atom of said thiol compound and said thiol group of said therapeutic agent can form a disulfide bond.