Patent ID: 6020358
Filing Date: 2000-02-01
Classification: A61K,A61P,C07D,Y02A

Abstract:
A sulfone selected from the group consisting of(a) a compound of the formula: ##STR4## in which: the carbon atom designated * constitutes a center of chirality;Y is C.dbd.O, CH.sub.2, or CH.sub.2 C.dbd.O;each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, independently of the others, is hydrogen, halo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, hydroxy, or --NR.sup.8 R.sup.9 ; or any two of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 on adjacent carbon atoms, together with the depicted phenylene ring are naphthylideneeach of R.sup.5 and R.sup.6, independently of the other, is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, cyano, or cycloalkoxy of up to 18 carbon atoms;R.sup.7 is hydroxy, alkyl of 1 to 8 carbon atoms, phenyl, benzyl, or NR.sup.8' R.sup.9' ; each of R.sup.8 and R.sup.9 taken independently of the other is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl, or benzyl, or one of R.sup.8 and R.sup.9 is hydrogen and the other is --COR.sup.10, or --SO.sub.2 R.sup.10, or R.sup.8 and R.sup.9 taken together are tetramethylene, pentamethylene, hexamethylene, or --CH.sub.2 CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 -- in which X.sup.1 is --O--, --S-- or --NH--;each of R.sup.8' and R.sup.9' taken independently of the other is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl, or benzyl, or one of R.sup.8' and R.sup.9' is hydrogen and the other is --COR.sup.10', or --SO.sub.2 R.sup.10', or R.sup.8' and R.sup.9' taken together are tetramethylene, pentamethylene, hexamethylene, or --CH.sub.2 CH.sub.2 X.sup.2 CH.sub.2 CH.sub.2 -- in which X.sup.2 is --O--, --S-- or --NH--;R.sup.10 is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl; andR.sup.10' is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl; and(b) the acid addition salts of said compounds which contain a nitrogen atom susceptible of protonation.