Patent ID: 8435754
Filing Date: 2013-05-07
Classification: A61P,C12N,G01N

Abstract:
1. A method of diagnosing the presence of a tumor in a mammal suspected of having a primary central nervous system malignant neuroectodermal tumor, comprising: (a) obtaining a test sample comprising tissue or cells from said mammal suspected of having a primary central nervous system malignant neuroectodermal tumor; (b) contacting said test sample obtained from the mammal with a molecule that binds to a CDO (cell adhesion molecule-related/down-regulated by oncogene) polypeptide, which molecule is an anti-CDO antibody or CDO-binding antibody fragment that binds to a CDO polypeptide having the amino acid sequence of SEQ ID NO: 4; (c) detecting the formation of a complex between the CDO-binding molecule and the CDO polypeptide in the test sample; (d) comparing said formation of a complex in the test sample relative to a control sample, wherein the formation of more complex in the test sample relative to a control sample is indicative of the presence of the tumor in the mammal; and (e) if the comparison in (d) is indicative of the presence of the tumor, administering to said mammal having said tumor a molecule that blocks the smoothened receptor from transmitting to a downstream component in the hedgehog signaling pathway.