Patent ID: 6265435
Filing Date: 2001-07-24
Classification: A61K,Y10S

Abstract:
A method for enhancing the penetration of an ophthmalmic drug through the corneal epithelium in treating the interior of the human eye comprising the steps of:applying a therapeutic ophthalmic drug other than a loop diuretic in aqueous solution topically to the corneal epithelium;blocking the Na.sup.+ 2Cl.sup.- K.sup.+ cotransporter of the corneal epithelium by topical application of a loop diuretic, so as to stop outwardly directed ion movement through the baso-lateral membranes of the corneal epithelium and correspondingly increase the net inwardly directed movement of ions through the corneal epithelium and into the eye interior; andtaking the therapeutic ophthalmic drug into the eye interior along with the inwardly directed ion movement by the associated solvent drag.