Patent ID: 6080747
Filing Date: 2000-06-27
Classification: A61K,A61P

Abstract:
A method for inhibiting JAK-3 tyrosine kinase activity comprising contacting JAK-3 tyrosine kinase with a compound of formula I: ##STR13## wherein X is HN, R.sub.11 N, S, O, CH.sub.2, or R.sub.11 CH;R.sub.11 is hydrogen, (C.sub.1 -C.sub.4)alkyl, or (C.sub.1 -C.sub.4)alkanoyl;R.sub.1 -R.sub.8 are each independently hydrogen, hydroxy, mercapto, amino, nitro, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, or halo;wherein two adjacent groups of R.sub.1 -R.sub.5 together with the phenyl ring to which they are attached may optionally form a fused ring, for example forming a naphthyl or a tetrahydronaphthyl ring; andfurther wherein the ring formed by the two adjacent groups of R.sub.1 -R.sub.5 may optionally be substituted by 1, 2, 3, or 4 hydroxy, mercapto, amino, nitro, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, or halo or R.sub.9 and R.sub.10 can independently be a prodrug derivative.