Patent ID: 6842641
Filing Date: 2005-01-11
Classification: A61B,A61M

Abstract:
1. An apparatus for performing in-vivo sonoporation of skin area and transdermal and/or intradermal delivery of a drug solution comprising: an ultrasound horn having a tip submerged in said drug solution and applying ultrasound radiation to said drug solution wherein said ultrasound radiation has a frequency in the range of 15 KHz and 1 MHz and is applied at an intensity, for a period of time and at a distance from said skin area effective to generate cavitation bubbles, wherein said cavitation bubbles collapse and transfer their energy into the skin area thus causing the formation of pores in the skin area; and wherein said ultrasound radiation intensity and distance from the skin area are also effective in generating ultrasonic jets, said ultrasonic jets driving said drug solution transdermally through said formed pores into the skin area.