Patent ID: 6455700
Filing Date: 2002-09-24
Classification: A61P,C07C,C07D

Abstract:
A process for the preparation of a compound of formula whereinR5, R6, R7 independently of one another denote H, alkyl, cycloalkyl, alkenyl, aryl, aralkyl, alkanoyl, benzoyl, heteroaryl, dialkylamino, dialkylaminoalkyl, trialkylammoniumalkyl, cyano, alkyloxycarbonyl, aralkyloxycarbonyl, OH, O-alkyl or O-aryl, wherein the alkyl groups contain 1 to 5 carbon atoms, the cycloalkyl groups contain 3 to 6 carbon atoms, the alkenyl groups contain 2 to 5 carbon atoms, aryl denotes phenyl, or phenyl or naphthyl substituted by methyl or halogen; or R5 and R6 or R6 and R7 together form the group (CH2)2â€”, â€”(CH2)3â€”, â€”(CH2)4â€”, â€”(CH2)5â€” or â€”(CH2)2O(CH2)2; and R8 represents H, alkyl with 1 to 5 carbon atoms or cycloalkyl with 3 to 6 carbon atoms or R7+R8 together form the group â€”(CH2)2â€”, â€”(CH2)3â€”, â€”(CH2)4â€”, â€”(CH2)5â€” or â€”(CH2)2 O(CH2)2â€”; said process comprises reacting under suitable conditions an amide of formula with a piperidine of formula to produce the final product compound and if desired subsequently isolating the product;whereinR5, R6, R7 and R8 have the meaning given above.