Patent ID: 6342480
Filing Date: 2002-01-29
Classification: A61K,A61P,C07K

Abstract:
A compound, W-Z-M, comprising a component, M, chosen from the group consisting of therapeutic agents, said M being linked to a ligand, W-Z, said ligand comprising an arm, Z, linked to a terminal group, W, wherein linkage in the arm, Z, of the ligand, W-Z, or between the arm, Z, and the component, M, prevents intracellular entry of the compound, W-Z-M, wherein said linkage can be selectively cleaved by a factor or factors secreted by a target cell so as to permit entry of the therapeutic agent into said target cell, wherein the terminal group, W, provides for the stability of the compound, W-Z-M, in the serum and the circulating blood, wherein W provides for the stability of the compound when less than 20% of the compound is cleaved during storage of the compound in human blood at 37Â° C. for more than 2 hours, and further wherein M is an anti-inflammatory agent.