Patent ID: 6593497
Filing Date: 2003-07-15
Classification: C07C,C08G,C08L

Abstract:
A compound of Formula (II): wherein:Ar1 is a phenyl ring of formula (c): â€ƒwherein: R4 is hydrogen, alkyl, halo, or alkoxy;. R5 is hydrogen, hydroxy, halo, amino, or â€”NHSO2Ra where Ra is alkyl; and R6 is hydrogen, halo, alkoxy, substituted alkyl, sulfonylamino, aminoacyl, or acylamino; X is selected from the group consisting of -(alkylene)-Oâ€”{(alkylene)-Oâ€”}n-(alkylene)- (where n is an integer of from 0-9) and further wherein alkylene is â€”(CH2)6; and Ar is either: (i) a phenyl ring of formula (câ€²): â€ƒwherein: R4 is hydrogen, alkyl, halo, or alkoxy; R5 is hydrogen, hydroxy, halo, amino, or â€”NHSO2Ra where Ra is alkyl; and R6 is hydrogen, halo, hydroxy, alkoxy, substituted alkyl, sulfonylamino, aminoacyl, or acylamino; or (ii) a phenyl ring of formula (d): â€ƒwherein: R7 is hydrogen, alkyl, alkenyl, substituted alkyl, halo, alkoxy, substituted alkoxy, hydroxy, aminoacyl, or heteroaryl; and R8 is hydrogen, halo, alkoxy, substituted alkoxy, acylamino; or (iii) naphthyl, pyridyl, benzimidazol-1-yl, indolyl, 2-cyanoindolyl, carbazolyl, 4-methylindanyl, 5-(CH3CO2CH2Oâ€”)-1,2,3,4-tetrahydronaphthyl, 1H-2oxoindole, 2,3,4-trihydrothianaphthalene, or 4-oxo-2,3-dihydrothianapthalene; or a pharmaceutically acceptable salt thereof.