Patent ID: 6544771
Filing Date: 2003-04-08
Classification: A61K,A61L,A61P,C07K,C12N,C12Y

Abstract:
A recombinant retroviral vector useful to nonselectively transduce cells, comprising:(a) a 5â€² LTR derived from a retrovirus of interest; (b) a splice donor site located 3â€² to said 5â€² LTR; (c) a Psi packaging site located 3â€² to said splice donor site; (d) a consensus splice acceptor site located 3â€² to said Psi packaging site; (e) an insertion site for a gene of interest located 3â€² to said consensus splice acceptor site; (f) a 3â€² LTR derived from a retrovirus of interest located 3â€² to said insertion site; and wherein said vector does not contain a complete selectable marker gene used for the transduction of said cells, or a complete gag, env, or pol gene between said 5â€² and 3â€² LTR.