Patent ID: 6740739
Filing Date: 2004-05-25
Classification: A61K,A61P,C07K

Abstract:
An isolated soluble Apo-2 ligand polypeptide selected from the group consisting of:(a) a polypeptide comprising amino acids 41-281 of FIG. 1A (SEQ ID NO:1) and having an alanine residue substituted for the amino acid at position 203, 269 or 218 in the sequence of FIG. 1A (SEQ ID NO:1); (b) a polypeptide comprising amino acids 91-281 of FIG. 1A (SEQ ID NO:1) and having an alanine residue substituted for the amino acid at position 203, 269 or 218 in the sequence of FIG. 1A (SEQ ID NO:1); (c) a polypeptide comprising amino acids 92-281 of FIG. 1A (SEQ ID NO:1) and having an alanine residue substituted for the amino acid at position 203, 269 or 218 in the sequence of FIG. 1A (SEQ ID NO:1); (d) a polypeptide comprising amino acids 114-281 of FIG. 1A (SEQ ID NO:1) and having an alanine residue substituted for the amino acid at position 203, 269 or 218 in the sequence of FIG. 1A (SEQ ID NO:1); and (e) a polypeptide which is a fragment of (a), (b), (c), or (d) and induces apoptosis in a mammalian cell or binds the DR4, DR5, or DcR2 receptor.