Patent ID: 6018019
Filing Date: 2000-01-25
Classification: A61K,A61P,C07H,C07K,Y02A,Y02P,Y10S

Abstract:
A synthetic peptide having an amino acid sequence which includes at least one antigenic determinant of at least one outer membrane protein (OMP) of Haemophilus influenzae, wherein said OMP is selected from the group consisting of (a) the P1 protein of Haemophilus influenzae type b and said amino acid sequence is at least one selected from the amino acid sequences 39 to 64 (SEQ ID NO: 12) and 179 to 218 (SEQ ID NO: 15) as set forth in Table 1, (b) the P2 protein of Haemophilus influenzae type b and said amino acid sequence is at least one selected from any of the amino acid sequences 1 to 14 (SEQ ID NO: 16), 53 to 81 (SEQ ID NO: 20), 125 to 150 (SEQ ID NO: 23), 148 to 174 (SEQ ID NO: 24), 193 to 219 (SEQ ID NO: 26), 219 to 244 (SEQ ID NO: 27), 241 to 265 (SEQ ID NO: 28), 263 to 289 (SEQ ID NO: 29), 285 to 306 SEQ ID NO: 30), 302 to 319 (SEQ ID NO:31), and 314 to 341 (SEQ ID NO: 32) as set forth in Table 2, and (c) the P6 protein of Haemophilus influenzae type b and said amino acid sequence is at least one selected from any of the amino acid sequences set forth in Table 3.