Patent ID: 6476058
Filing Date: 2002-11-05
Classification: C07B,C07D

Abstract:
A method for blocking calcium channels, while avoiding the concomitant liability of adverse effects associated with administration of racemic amlodipine, which comprises administering to an animal in need of calcium channel blocking therapy, an amount of deuterated S(âˆ’) amlodipine, or a pharmaceutically acceptable salt thereof, substantially free of its R(+) stereoisomer, wherein the deuterated S(âˆ’) amlodipine or salt thereof, comprises an amlodipine selected from the genus described by: wherein R represents either hydrogen or deuterium; and wherein R1 represents either hydrogen or deuterium, and at least one of the R or R1 is deuterium, said amount being sufficient to provide calcium channel blockade but insufficient to cause said adverse effects of racemic amlodipine.