Patent ID: 7547725
Filing Date: 2009-06-16
Classification: A61P,C07D

Abstract:
1. A method of treating a disease selected from the group consisting of Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome, in a subject, said method comprising administering a compound of formula I to said subject in an amount sufficient to alleviate the symptoms or progress of said disease, wherein said compound of formula I is of the structure: wherein: T is selected from the group consisting of CHO, COR R R R n=1-3; R W, Y and Z are independently selected from the group consisting of C, CR R X is selected from the group consisting of O, S, SO R R or a pharmaceutically acceptable salt, hydrate, or prodrug thereof.