Patent ID: 8986609
Filing Date: 2015-03-24
Classification: A61K,A61L,A61P,C08G,C08L

Abstract:
1. A method for sterilizing a biodegradable poly(ethylene glycol) based insoluble hydrogel comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the method comprising the steps of: (a) providing the hydrogel; (b) solvating the hydrogel in a protective solvent, or in a mixture of the protective solvent with another protective solvent, or in an aqueous solution thereof; and (c) subjecting the solvated hydrogel, in the presence of the protective solvent, to gamma radiation; wherein the protective solvent comprises at least one component selected from the group consisting of NMP, DMA, DME and DMI; and wherein the protective solvent optionally contains one or more protecting agents.