Patent ID: 8530674
Filing Date: 2013-09-10
Classification: C07D

Abstract:
1. A process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine, comprising steps of: performing an N,O-cleavage reaction on a compound represented by formula (II), to form (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol as shown in formula (III), reacting the (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol with halonaphthalene in DMSO to form (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine represented by the following formula, wherein R is a hydrogen atom, C wherein KOR