Patent ID: 6046206
Filing Date: 2000-04-04
Classification: A61K

Abstract:
A method of treating a patient having precancerous lesions in the need of treatment, comprising administering to the patient sensitive to such a compound a pharmacologically effective amount of a compound of the formula: ##STR226## wherein R1, R2, R3 and R4, each of which may be the same or different, are selected from a hydrogen atom, a alkoxy group having 1 to 6 carbon atoms, a hydroxyalkyl group, a cyano group, an acylamino group, a carboxyl group which may be protected or two of R1, R2, R3 or R4 may together form methylenedioxy, ethylenedioxy, or a phenyl ring;R5 is selected from a hydrogen atom, a halogen atom, a hydroxyl group, a hydrazino group, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 2 to 8 carbon atoms, an alkenyl group which may be protected having 2 to 8 carbon atoms, a carboxyalkenyl group which may be protected having 3 to 8 carbon atoms, a hydroxyalkyl group having 1 to 6 carbon atoms, or a carboxyl group which may be protected,R6 is selected from a hydrogen atom, a alkyl group having 1 to 6 carbon atoms, an acyl group, a lower alkoxyalkyl group having 2 to 8 carbon atoms, a carboxyalkyl group having 2 to 8 carbon atoms which may be protected or a hydroxyalkyl group having 2 to 8 carbon atoms;R7 is selected from a hydrogen atom, a hydroxyl group, a carboxyl group which may be protected, a cyano group, an acyl group, or a benzyl group which may be substituted, said substitutions, which may be the same or different, are selected from a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a alkyl group having 1 to 6 carbon atoms, a alkoxy group having 1 to 6 carbon atoms, a alkoxyalkyl group having 2 to 8 carbon atoms, a alkenyl group having 2 to 8 carbon atoms, an acyl group an acylamino group, an alkylsulfonylamino group, a hydroiminoalkyl group, an alkyloxy-carbonylamino group, or an alkyloxybarbonyloxy group, wherein the alkyls are 2 to 8 carbon atoms; andY is a group represented by the formula --(CH2)q--wherein q is an integer of 1 to 8, when q is an integer of 1 to 8, each carbon atom may have from 1 to 2 substituents, or Y is a group represented by the formula: ##STR227##