Patent ID: 6949534
Filing Date: 2005-09-27
Classification: A61K,C07C,C07D,C07K,G01N

Abstract:
1. A cell adhesion inhibitor having Formula (I) wherein A comprises a VLA-4 specificity determinant which does not impart significant IIb/IIIa activity and is selected from the group consisting of alkyl; aliphatic acyl optionally substituted with N-alkyl- or N-arylamido; aroyl; heterocycloyl; aralkylcarbonyl optionally substituted with aryl; heterocycloalkylcarbonyl; alkoxycarbonyl; aralkyloxycarbonyl; cycloalkylcarbonyl optionally fused with aryl; heterocycloalkoxycarbonyl; alkylaminocarbonyl optionally substituted with bis(alkylsulfonyl)amino, alkoxycarbonylamino or alkenyl; arylaminocarbonyl optionally substituted with bis(alkylsulfonyl)amino, alkoxycarbonylamino or alkenyl; aralkylaminocarbonyl optionally substituted with bis(alkylsulfonyl)amino, alkoxycarbonylamino or alkenyl; alkylsulfonyl; aralkylsulfonyl; arylsulfonyl; cycloalkylsulfonyl optionally fused with aryl; heterocyclylsulfonyl; heterocyclylalkylsulfonyl; aralkoxycarbonyl; aryloxycarbonyl; cycloalkyloxycarbonyl; heterocyclyloxycarbonyl; heterocyclylalkoxycarbonyl; mono- or di-alkylaminocarbonyl optionally substituted with aryl; (alkyl)(aralkyl)aminocarbonyl; mono- or di-aralkylaminocarbonyl; mono- or di-arylaminocarbonyl; (aryl)(alkyl)aminocarbonyl; mono- or di-cycloalkylaminocarbonyl; heterocyclylaminocarbonyl; heterocyclylalkylaminocarbonyl; (alkyl)(heterocyclyl) aminocarbonyl; (alkyl)(heterocyclylalkyl)aminocarbonyl; (aralkyl)(heterocyclyl)aminocarbonyl; (aralkyl)(heterocyclylalkyl)aminocarbonyl; alkenoyl optionally substituted with aryl; alkenylsulfonyl optionally substituted with aryl; alkynoyl optionally substituted with aryl; alkynylsulfonyl optionally substituted with aryl; cycloalkenylcarbonyl; cycloalkenylsulfonyl; cycloalkylalkanoyl; cycloalkylalkylsulfonyl; arylaroyl; biarylsulfonyl; alkoxysulfonyl; aralkoxysulfonyl; alkylaminosulfonyl; aryloxysulfonyl; arylaminosulfonyl; N-arylurea-substituted alkanoyl; N-arylurea-substituted alkylsulfonyl; cycloalkenyl-substituted carbonyl; cycloalkenyl-substituted sulfonyl; alkenoxycarbonyl optionally substituted with aryl; alkenoxysulfonyl optionally substituted with aryl; alkynoxycarbonyl optionally substituted with aryl; alkynoxysulfonyl optionally substituted with aryl; alkenyl-aminocarbonyl optionally substituted with aryl; alkynyl-aminocarbonyl optionally substituted with aryl; alkenyl-aminosulfonyl optionally substituted with aryl; alkynyl-aminosulfonyl optionally substituted with aryl; acylamino-substituted alkanoyl; acylamino-substituted alkylsulfonyl; aminocarbonyl-substituted alkanoyl; carbamoyl-substituted alkanoyl; carbamoyl-substituted alkylsulfonyl; heterocyclylalkanoyl; heterocyclylaminosulfonyl; carboxyalkyl-substituted aralkoyl; carboxyalkyl-substituted aralkylsulfonyl; oxocarbocyclyl-fused aroyl; oxocarbocyclyl-fused arylsulfonyl; heterocyclylalkanoyl; N′,N′-alkyl, arylhydrazinocarbonyl; aryloxy-substituted alkanoyl; heterocyclylalkylsulfonyl; alkenyl; alkynyl; cycloalkyl; aryl-fused cycloalkyl; cycloalkenyl; aryl; aryl-substituted alkyl; aryl-substituted alkenyl; aryl-substituted alkynyl; cycloalkyl-substituted alkyl; cycloalkenyl-substituted cycloalkyl; biaryl; alkoxy; alkenoxy; alkynoxy; aryl-substituted alkoxy; aryl-substituted alkenoxy; aryl-substituted alkynoxy; alkylamino; alkenylamino; alkynylamino; aryl-substituted alkylamino; aryl-substituted alkenylamino; aryl-substituted alkynylamino; aryloxy; arylamino; N-alkylurea-substituted alkyl; N-arylurea-substituted alkyl; alkylcarbonylamino-substituted alkyl; aminocarbonyl-substituted alkyl; heterocyclyl; heterocyclyl-substituted alkyl; heterocyclyl-substituted amino; carboxyalkyl substituted aralkyl; oxocarbocyclyl-fused aryl; arylurea-substituted arylalkylcarbonylamino; heteroarylamido-substituted arylalkylcarbonylamino; and arylurea-substituted arylurea, and B is of Formula IIIa wherein n=0-5; W is selected from the group consisting of CO R R provided that R