Patent ID: 6518429
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (3): whereinX represents O or S, B represents hydrogen, or lower alkyl which may be optionally substituted by hydroxy, mercapto, lower alkoxy, lower alkylthio or aryl, C represents hydrogen, or lower alkyl which may be optionally substituted by aryl; or represents a radical selected from the following group: whereinR11 and R12 independently represent hydrogen, lower alkyl, lower alkoxy, halogen, cyano, hydroxycarbonyl, aminocarbonyl, aminothiocarbonyl, hydroxy, phenyl or phenoxy, R13 and R14 independently represent hydrogen, lower alkyl, aryl or wherein X is O or S, n4 is an integer of 2 to 4 and R15 is lower alkyl, D represents a radical selected from the following group: wherein R10 represents hydrogen, lower alkyl or lower alkoxy,Q represents O, S, S&boxH;O or SO2, Z represents O, S, S&boxH;O, SO2, C&boxH;O or C&boxH;S, or represents CHâ€”R20 or Nâ€”R20 (wherein R20 is hydrogen, lower alkyl or hydroxy), n5 denotes an integer of 1 to 3, and R18 and R19 independently represent hydrogen, halogen, hydroxy, cyano, lower alkyl, lower alkoxy, alkoxyalkyl, alkylthio, hydroxycarbonyl, aminocarbonyl, aminothiocarbonyl, alkylsulfonyl, alkylthioalkyl, alkylthioalkyloxy, aryl; or oxy, thio, sulfonyl or lower alkyl substituted by aryl.