Patent ID: 7741529
Filing Date: 2010-06-22
Classification: A01K

Abstract:
1. A transgenic mouse model for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) on a genetic basis carrying an R4496C mutation in the cardiac Ryanodine receptor (RyR2) gene in a heterozygous form, wherein sustained ectopic activity leading to bidirectional Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF) is obtained by exposure of the mouse to a RyR-agonist (caffeine) or during adrenergic stimulation and wherein said transgenic mouse model further exhibits the following characteristics: adrenergically mediated arrhythmogenesis; normal electrocardiogram at baseline; lack of fatty fibrous infiltration in the heart; absence of extra-cardiac abnormalities; incomplete response to beta blocker therapy; and incomplete penetrance.