Patent ID: 6444645
Filing Date: 2002-09-03
Classification: A61K,A61P,C07K,Y02A

Abstract:
A crosslinked indolicidin (X-indolicidin) analog having the amino acid sequence:Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Pro-Xaa6-Xaa6-Pro-Xaa5-Xaa7-Xaa7-Xaa5, wherein: Xaa1 is Ile, Leu, Val, Ala, Gly or absent; Xaa2 is Ile, Leu, Val, Ala, Gly or absent; Xaa3 is Pro or absent; Xaa4 is Trp, Phe, Cys, Glu, Asp, Lys, AlaL or absent; Xaa5 is Arg, Lys or absent; Xaa6 is Trp, Phe, Cys, Glu, Asp, Lys, or AlaL; Xaa7 is Arg, Lys or absent; and Xaa8 is homoserine (Hse), Met, Met-Xaa9-Met or absent; wherein Xaa9 is one or more amino acids; provided that a crosslink can be formed between two amino acids selected from the group consisting of: a) Xaa4, when present, and an Xaa6; and b) a first Xaa6 and another Xaa6; and further provided that: if Xaa2 is absent, Xaa1 is absent; if Xaa3 is absent, Xaa1 and Xaa2 are absent; if Xaa4 is absent, Xaa1, Xaa2 and Xaa3 are absent; and if Xaa5 is absent, Xaa1, Xaa2, Xaa3 and Xaa4 are absent, and wherein said crosslinked indolicidin analog has antimicrobial activity.