Patent ID: 6274686
Filing Date: 2001-08-14
Classification: B01J,C07B,G01N

Abstract:
A synthetic molecularly imprinted co-polymer prepared by steps consisting essentially of:copolymerizing (i) at least one monomer providing the synthetic molecularly imprinted copolymer with a free amide group, and (ii) at least one crosslinker, in the presence of (i) at least one polar organic solvent, and (ii) an enantiomer print molecule optionally having carboxylic acid functionality to form a co-polymerized composition;substantially removing from the co-polymerized composition the enantiomeric print molecule to form the synthetic molecularly imprinted co-polymer;wherein the print molecule, the monomer providing free amide, and the crosslinker are provided in a ratio sufficient to form specific noncovalent binding sites for the print molecule in the molecularly imprinted copolymer;and wherein the molecularly imprinted copolymer exhibits toward racemic mixtures of the enantiomer print molecule in polar solvent an enantiomeric separation factor alpha of at least 2.03.