Patent ID: 8492438
Filing Date: 2013-07-23
Classification: A61K,A61P

Abstract:
1. A method for treating a skin disorder, comprising administering to a subject in need thereof a composition containing an effective amount of a histone hyperacetylating agent or a pharmaceutically acceptable salt thereof, and a cosmetically or pharmaceutically acceptable carrier, wherein the skin disorder is selected from the group consisting of rosacea, pityriasis rosea, erythema, rhinophyma, and a rosacea-associated disorder that is pimple, papule, pustule, or telangiectasia, and the histone hyperacetylating agent is selected from the group consisting of trichostatin A, trichostatin C, oxamflatin, trapoxin A, FR901228, apicidin, HC-Toxin, WF27082, chlamydocin, salicylihydroxamic acid, suberoylanilide hydroxamic acid, azelaic bishydroxamic acid, azelaic-1-hydroxamate-9-an-ilide, M-carboxycinnamic acid bishydroxamide, 6-(3-chlorophenylureido) carpoic hydroxamic acid, MW2796, MW2996, sodium butyrate, arginine butyrate, isovalerate, valerate, 4-phenylbutyrate, propionate, butyramide, isobutyramide, phenylacetate, 3-bromopropionate, valproic acid, valproate, tributyrin, MS-27-275 or a 3′-amino derivative thereof, depudecin, and scriptaid.