Patent ID: 6372216
Filing Date: 2002-04-16
Classification: A61K,C07K

Abstract:
A method of producing an antibody composition, wherein said antibody composition (1) contains a substantial hyperconcentration of a multiplicity of hepatitis C virus neutralizing antibodies effective to neutralize different strains of hepatitis C virus and (2) blocks hepatitis C virus infection in subjects infected with hepatitis C virus, comprising:(a) obtaining anti-hepatitis C virus-positive blood units which contain high titers of hepatitis C virus neutralizing antibodies from a multiplicity of anti-hepatitis C virus-positive blood donors; (b) pooling the blood units which contain high titers of hepatitis C virus neutralizing antibodies to form a pooled plasma which contains a high titer of hepatitis C virus neutralizing antibodies; and (c) fractioning the pooled plasma to produce the antibody composition wherein infectious agents in the composition have been inactivated.