Patent ID: 6492409
Filing Date: 2002-12-10
Classification: A61P,C07D

Abstract:
A compound of formula (IIâ€²): wherein:X is O or S, R is H, OH, NH2, C1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, R1 is H, C1-6alkyl, fluoro substituted C1-6alkyl, phenyl, benzyl, carboC1-6alkoxy, carbobenzyloxy, carbohydroxy, carbamoyl, or methyl(N-C1-6alkylcarbamoyl), R2 and R21 are, independently, H, C1-6alkyl, haloC1-6alkyl, benzyl, C1-3alkoxy substituted benzyl, nitrileC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, (pyridinylmethyl)aminoC1-6alkyl, (mono- or di-C1-6alkyl)aminoC1-6alkyl, (mono- or di-C1-3haloalkyl)aminoC1-6alkyl, aminoC3-7cycloalkyl, (mono- or di-C1-6alkyl)aminoC3-7cycloalkyl, (aminoC3-7cycloalkyl)C1-3alkyl, (hydroxyC1-6alkyl)aminoC1-6alkyl, (aminoC1-6alkyl)aminoC1-6alkyl, (C1-6alkynyl)aminoC1-6alkyl, (benzyl)aminoC1-6alkyl, (mono- or di-C1-3alkoxy substituted benzyl)aminoC1-6alkyl, (aminoC1-3alkylphenyl)C1-3alkyl, (aminoC1-3alkylthiophenyl)C1-3alkyl, (aminoC1-3alkylpyridinyl)C1-3alkyl, guanidino C1-6alkyl, (guanidinoC1-3alkylphenyl)C1-3alkyl, amidinoC1-6alkyl or amidinothioC1-6alkyl; R3, R31, R5 and R51 are each independently H, halogen, C1-6alkyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, hydroxy, amino, nitro or nitrile, and R4 and R41 are, independently, H, C1-3alkyl or together with R2 or R21, form an annulated ring which may be substituted by hydroxyC1-3alkyl, amidinothioC1-3alkyl, or aminoC1-3alkyl, or a salt thereof, a solvate thereof, or a solvate of a salt thereof.