Patent ID: 6096709
Filing Date: 2000-08-01
Classification: A61K,A61P,C07K

Abstract:
A method of accelerating wound healing, comprising applying to a wound an effective amount to accelerate wound healing of at least one peptide other than Angiotensin II, said peptide consisting of at least three contiguous amino acids and having a sequence corresponding to a subsequence of groups R.sup.1 --R.sup.8 in general formula I:R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4 --R.sup.5 --R.sup.6 --R.sup.7 --R.sup.8 (SEQ ID NO:15), whereinR.sup.1 is selected from the group consisting of Asp, Glu, Asn, Acpc, Ala, Me.sup.2 Gly, Pro, Bet, Glu (NH.sub.2), Gly, Asp(NH.sub.2) and Suc;R.sup.2 is selected from the group consisting of Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys;R.sup.3 is selected from the group consisting of Val, Ala, Leu, Ile, Gly, Pro, Aib, Acpc and Tyr;R.sup.4 is selected from the group consisting of Tyr, Thr, Ser and azaTyr;R.sup.5 is selected from the group consisting of Ile, Ala, Leu, Val and Gly;R.sup.6 is His or Arg;R.sup.7 is Pro or Ala; andR.sup.8 is selected from the group consisting of Phe, Phe(Br), Ile and Tyr,excluding sequences wherein R.sup.4 is an amino terminal Tyr group of the peptide.