Patent ID: 6072030
Filing Date: 2000-06-06
Classification: A61K,A61P,A61Q,C07K

Abstract:
A method for obtaining hydroxyproline-rich glycoproteins which comprises:a) culturing cells of Gingko biloba or Lycopersicum esculentum in a liquid culture medium for 3 to 12 days;b) extracting the cultured cells with an alcohol having one to three carbon atoms in the presence of a dilute acid material to obtain an extract;c) neutralizing, concentrating and heating the extract at a temperature of between 70.degree. C. and 100.degree. C.; andd) centrifuging the heated extract to obtain a supernatant and precipitate, discarding the precipitate, and subjecting the supernatant to fractional ultrafiltration and dialysis to obtain the hydroxyproline-rich glycoproteins.