Patent ID: 8663967
Filing Date: 2014-03-04
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. An isolated arginine deiminase mutant with enzymatic activity of degrading arginine into citruline, the amino acid sequence of which comprises one or more substitutions of K9N, T; K59Q; K66R, A; K93E, A, Q; K111R, A; K119Q, L, M; K121Q, I; K122E, L; K126E, S, R; K1781, E, D; K1961, R; K209G , T, D; K243E, V, R; K249D, Q; K263N, Q; K279Y, T; K293R, H, E; K325V, I; K380T, R, E, and K406E, D, S, compared with the arginine deiminase derived from mycoplasma arginini with the amino acid sequence of SEQ ID NO: 1.