Patent ID: 6620838
Filing Date: 2003-09-16
Classification: A61P,C07D

Abstract:
A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein:n is 2, 3 or 4; R1 is hydrogen, C(&boxH;O)R2, C(&boxH;O)OR2, C(&boxH;O)NHR2, C(&boxH;O)NR2R3, or S(&boxH;O2)NR2R3; R2 and R3 are independently C1-8alkyl, C6-12aryl, C7-12arylalkyl, or a five- or six-membered heterocycle containing up to two heteroatoms selected from O, NR4 and S(O)q, wherein each of the above groups are optionally substituted with one to three substituents independently selected from R5 and q is 0, 1 or 2; R4 is hydrogen or C1-4alkyl; R5 is hydrogen, halogen, hydroxy, C1-6alkyl, C1-4alkoxy, C1-4acyloxy, C1-4thio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, (hydroxy)C1-4alkyl, C6-12aryl, C7-12aralkyl, COOH, CN, CONHOR6, SO2NHR6, NH2, C1-4alkylamino, C1-4dialkylamino, NHSO2R6, NO2, or a five- or six-membered heterocycle, where each occurrence of R6 is independently C1-6alkyl; X is hydrogen, halogen or trifluoromethyl; and Y is halogen or trifluoromethyl.