Patent ID: 8293750
Filing Date: 2012-10-23
Classification: A61P,C07D

Abstract:
1. A method for treating mild to severe pain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I wherein R i) phenyl optionally substituted with one to two substituents independently selected from the group consisting of C ii) pyridinyl optionally substituted with one substituent selected from the group consisting of C iii) pyrimidin-5-yl; or, R Y is ethynyl or a bond; R or R X is O or CH L is absent and R i) pyrrolidin-2-yl; ii) 1-amino-eth-1-yl; and iii) 1-amino-cyclopent-1-yl; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.