Patent ID: 8106047
Filing Date: 2012-01-31
Classification: A61P,C07D

Abstract:
1. A compound of formula I in which R1 is —U-A, in which U is a direct bond, or methylene (—CH A is phenyl, pyridinyl, thienyl, or R11- and/or R111-substituted phenyl, in which R11 is 1-4C-alkyl, halogen, trifluoromethyl, hydroxyl, 1-4C-alkoxy, completely or predominantly fluorine-substituted 1-4C-alkoxy, phenoxy, 1-4C-alkoxycarbonyl, morpholino, or di-1-4C-alkylamino, R111 is 1-4C-alkoxy, halogen, hydroxyl, or 1-4C-alkyl, R2 is —N(H)—S(O) R3 is 1-4C-alkyl, phenyl, R31- and/or R311-substituted phenyl, phenyl-1-4C-alkyl, —N(R32)R33, Har1, or Har2, in which R31 is 1-4C-alkoxy, halogen, nitro, 1-4C-alkyl, trifluoromethyl, hydroxyl, 1-4C-alkoxycarbonyl, 3-7C-cyloalkylmethoxy, 1-4C-alkylcarbonyl, amino, morpholino, mono- or di-1-4C-alkylamino, or 1-4C-alkylcarbonylamino, R311 is 1-4C-alkoxy, halogen, 1-4C-alkyl, hydroxyl, or 3-7C-cyloalkylmethoxy, or R31 and R311 together are a 1-2C-alkylenedioxy group, R32 is hydrogen, or 1-4C-alkyl, R33 is 1-4C-alkyl, or R32 and R33 together and with inclusion of the nitrogen atom, to which they are attached, form a heterocyclic ring Het1, in which Het1 is optionally substituted by R34, and is a 3- to 7-membered monocyclic fully saturated heterocyclic ring radical comprising the nitrogen atom, to which R32 and R33 are bonded, and optionally one further heteroatom selected from the group consisting of nitrogen, oxygen and sulphur, in which R34 is 1-4C-alkyl, Har1 is optionally substituted by R35, and is a 5-membered monocyclic aromatic heteroaryl radical comprising one to four heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, whereby said Har1 radical is bonded to the parent molecular group via a ring carbon atom, in which R35 is 1-4C-alkyl, Har2 is optionally substituted by R36, and is a 6-membered monocyclic aromatic heteroaryl radical comprising one or two nitrogen atoms, whereby said Har2 radical is bonded to the parent molecular group via a ring carbon atom, in which R36 is 1-4C-alkyl, 1-4C-alkoxy, amino, morpholino, or mono- or di-1-4C-alkylamino, R4 is hydrogen, 1-4C-alkyl, pyridinyl, or pyrimidinyl, R5 is hydrogen, or 1-4C-alkyl, or R4 and R5 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring radical Het2 or Har3, in which Het2 is optionally substituted by R41, and is a 3- to 7-membered monocyclic fully saturated heterocyclic ring radical comprising the nitrogen atom, to which R4 and R5 are bonded, and optionally one further heteroatom selected from the group consisting of nitrogen, oxygen and sulphur, in which R41 is 1-4C-alkyl, Har3 is optionally substituted by R42, and is a 5-membered monocyclic unsaturated, aromatic heteroaryl radical comprising the nitrogen atom, to which R4 and R5 are bonded, and optionally one further nitrogen atom, in which R42 is 1-4C-alkyl, R6 is 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, aryl, or aryl-1-4C-alkyl, in which aryl is phenyl, or R61- and/or R62-substituted phenyl, in which R61 is 1-4C-alkyl, 1-4C-alkoxy, hydroxyl, or halogen, R62 is 1-4C-alkyl, 1-4C-alkoxy, or halogen, or a salt thereof.