Patent ID: 6136958
Filing Date: 2000-10-24
Classification: C07K

Abstract:
An antibody which specifically binds to an isolated, vertebrate Smoothened polypeptide, wherein said Smoothened polypeptide is encoded by a nucleic acid which hybridizes to the complement of the nucleic acid sequence of SEQ ID NO:3 under the following conditions: hybridization at 42.degree. C. in 50% formamide, 5.times.SSC, 10.times.Denhardt's, 0.05M sodium phosphate (pH 6.5), 0.1% sodium pyrophosnhate, 50 .mu.g/ml sonicated salmon sperm; and rinsing with 2.times.SSC and washing with 0.5.times.SSC, 0.1% SDS at 42.degree. C.