Patent ID: 8431726
Filing Date: 2013-04-30
Classification: C07D

Abstract:
1. A preparation method for a compound represented by formula (I), comprising the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III) using sodium borohydride/aluminum trichloride as a reduction reagent, wherein, in the formula (II), R wherein R then, oxidizing the substance represented by formula (III) to form a substance represented by formula (IV) using an oxidation reagent under basic condition, wherein R b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, and then condensing the obtained n-octanoyl chloride with 2-mercaptopyridine under basic condition to form a substance represented by formula (V), then, the substance represented by formula (V) is converted to a substance represented by formula (VI) under basic condition: wherein R c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to form a substance represented by formula (VII), wherein, R then, reacting with an acid to obtain the compound represented by formula (I); wherein, the sequence of the step a) and the step b) is alterable.