Patent ID: 6194416
Filing Date: 2001-02-27
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR23##whereinW is oxygen or sulphur;R is selected from the group consisting of --OR.sup.4 and --SR.sup.4 ;R.sup.4 is selected from the group consisting of C.sub.2-15 -alkenyl and C.sub.2-15 -alkynyl, each of which is optionally substituted with one or more substituents independently selected from the group consisting of halogen(s), --CF.sub.3, --CN, phenyl, and phenoxy wherein the phenyl or phenoxy is optionally substituted with one or more selected from the group consisting of halogen, --CN, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, --OCF.sub.3, --CF.sub.3, --CONH.sub.2 and --CSNH.sub.2 ;G is the azabicyclic ring system: ##STR24##R.sup.1 and R.sup.2 independently are selected from the group consisting of hydrogen, C.sub.1-15 -alkyl, C.sub.2-5 -alkenyl, C.sub.2-5 -alkynyl, C.sub.1-10 -alkoxy, and C.sub.1-5 -alkyl substituted with a substituent independently selected from the group consisting of --OH, --COR.sup.6 ', CH.sub.2 --OH, halogen, --NH.sub.2, carboxy, and phenyl;R.sup.6 ' is hydrogen or C.sub.1-6 -alkyl;m, n, p, and r, independently, are 0, 1 or 2;....... is a single or double bond;or a pharmaceutically acceptable salt thereof.