Patent ID: 8969118
Filing Date: 2015-03-03
Classification: B82Y,G01N,Y10S

Abstract:
1. A method for base recognition in an integration of a transistor and a nanochannel, the method comprising: forcing a target molecule down to a carbon nanotube a single base at a time in the nanochannel, the target molecule being forced to the carbon nanotube by applying a gate voltage to a top electrode of the transistor, by a narrow thickness of the nanochannel, or both by applying the gate voltage to the top electrode of the transistor and by the narrow thickness of the nanochannel; wherein the nanochannel having been patterned over the carbon nanotube exposes an exposed portion of the carbon nanotube at a bottom wall of the carbon nanotube, the top electrode of the transistor positioned over the exposed portion of the carbon nanotube through the nanochannel; wherein the exposed portion of the carbon nanotube is smaller than a separating distance between bases on the target molecule, the exposed portion of the carbon nanotube being configured to only accommodate the single base at a time; stretching the target molecule by the narrow thickness of the nanochannel and by applying a traverse voltage across a length direction of the nanochannel between a first electrode and a second electrode at opposite ends of the nanochannel in the length direction; wherein the target molecule is frictionally restricted by the narrow thickness of the nanochannel causing the target molecule to stretch as the target molecule restrictedly translocates in the length direction while the traverse voltage is applied; measuring a transistor current while the single base of the target molecule is forced down to the exposed portion of the carbon nanotube in the nanochannel, the single base affecting the transistor current; and determining an identity of the single base according to a change in the transistor current while the single base is forced down to the exposed portion of the carbon nanotube in the nanochannel.