Patent ID: 8895017
Filing Date: 2014-11-25
Classification: A61K,A61P,C07K

Abstract:
1. An isolated immunogenic HER-2 peptide which comprises an ECD-derived peptide, wherein the ECD-derived peptide comprises an amino acid sequence that (i) is 90% to 100% identical to amino acids 23-645 of SEQ ID NO: 5 or 95% to 100% identical to amino acids 25-647 of SEQ ID NO: 14, (ii) comprises amino acid sequences of at least four of the conserved T cell epitopes in the ECD of human HER-2 protein, and (iii) is 70% to 95% identical to the amino acid sequence of the ECD of human HER-2 protein, and wherein the amino acid sequence of the human HER-2 protein is set forth in SEQ ID NO: 1.