Patent ID: 8148557
Filing Date: 2012-04-03
Classification: A61P,C07J,C12N,C12P

Abstract:
1. A microbial method of producing Δ 5 -Tibolone (C 21 H 28 O 2 ), 6β-Hydroxy-Δ 4 -tibolone (C 21 H 28 O 3 ), 6α-Hydroxy-Δ 4 -tibolone (C 21 H 28 O 3 ), 15α-Hydroxy-Δ 4 -tibolone (C 21 H 28 O 3 ), 6α-Hydroxy-Δ 1,4 -tibolone (C 21 H 28 O 3 ) and 6β-Methoxy-Δ 4 -tibolone (C 22 H 30 O 3 ) by growing Gibberella fujikuroi (ATCC 10704) in a nutrient media containing tibolone.