Patent ID: 6096735
Filing Date: 2000-08-01
Classification: A61P,C07D

Abstract:
A benzoheterocyclic compound of the following formula (1): ##STR1127## wherein G is a group of the formula: ##STR1128## R.sup.1 is a hydrogen atom or a halogen atom, R.sup.2 is a hydrogen atom, or a group of the formula: -(O).sub.m -A-(CO).sub.u -NR.sup.6 R.sup.7 (in which m is 0 and u is 1, A is a lower alkylene group, R.sup.6 and R.sup.7 are the same or different and each is a hydrogen atom, a lower alkyl group, or an amino-substituted lower alkyl group having optionally a lower alkyl substituent, or R.sup.6 and R.sup.7 may bind together with the nitrogen atom to which they bond to form a 5- to 7-membered saturated heterocyclic group selected from the group consisting of a pyrrolidinyl group, piperidinyl group, a piperazinyl group, a morpholino group and a homopiperazinyl group, said heterocyclic group being optionally substituted by a lower alkyl group or a phenyl-lower alkyl group),R.sup.3 is a hydrogen atom,R is a pyridylcarbonyl group which may optionally have a substituent selected from a phenyl group having optionally a lower alkyl substituent and a pyridyl group on the pyridine ring, a quinolylcarbonyl group having optionally a phenyl substituent on the quinoline ring, an adamantylcarbonyl group, a thienylcarbonyl group having optionally a phenyl substituent on the thiophene ring, or a group of the formula: ##STR1129## (in which p is 1 or 2), R.sup.8 is a hydrogen atom, a lower alkyl group, a halogen atom or a lower alkoxy group, and R.sup.9 is a hydrogen atom, a lower alkoxy group, a cycloalkyl group, a lower alkyl group, a phenyl group having optionally a substituent selected from a lower alkyl group, a lower alkoxy group, a phenyl-lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, a halogen-substituted lower alkoxy group, a nitro group, an amino group having optionally a lower alkanoyl substituent, a phenyl group, and an amino-substituted lower alkoxy group having optionally a lower alkyl substituent, or a cycloalkenyl group),X is a methylene group,provided that when R.sup.2 is a hydrogen atom, and when R is a group of the formula: ##STR1130## and R.sup.8 in said group is a hydrogen atom, a lower alkyl group, a halogen atom, or a lower alkoxy group, then R.sup.9 should not be a hydrogen atom, orwhen R.sup.1 is a hydrogen atom, R.sup.2 is a hydrogen atom, then R.sup.9 should not be a phenyl group having optionally a substituent selected from a hydroxy group, a lower alkyl group, a lower alkoxy group and a lower alkanoyloxy group on the phenyl ring, orwhen R.sup.1 and R.sup.2 are simultaneously a hydrogen atom, then R should not be an unsubstituted pyridylcarbonyl group, nor an unsubstituted thienylcarbonyl group, orwhen R.sup.3 is a hydrogen atom, R.sup.2 is a hydrogen atom, then R.sup.9 should not be a hydrogen atom, a lower alkoxy group nor a lower alkyl group; ora pharmaceutically acceptable salt thereof.