Patent ID: 8198101
Filing Date: 2012-06-12
Classification: A61K,A61P,C07D

Abstract:
1. A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: each Q is independently (CHR Q each R is independently hydrogen, benzyl or C R each R A is CH, N, C—Br, C—Cl, C—SO Z and Z E is O, S or P; R R R R R X and Y are each independently hydrogen or may be taken with an adjacent X and Y to form an additional carbon-carbon bond; n is 0 or 1; m is an integer from 0 to 10 inclusive; p is 1 or 2; r is 0 or 1; w is 0 or 1; L is a linker/spacer group covalently bonded to, and replaces one hydrogen atom of one of the carbon atoms to which it is joined, said linker/spacer group being represented by the formula: wherein: or a pharmaceutically acceptable salt thereof.