Patent ID: 7371763
Filing Date: 2008-05-13
Classification: A61P,C07D

Abstract:
1. A compound of one of the following formulae or a pharmaceutically acceptable salt thereof, wherein D is —NH—C(O)—NH—, A is selected from the group consisting of substituted t-butylpyridyl groups, unsubstituted t-butylpyridyl groups, substituted (trifluoromethyl) pyridyl groups, unsubstituted (trifluoromethyl) pyridyl groups, substituted isopropylpyridyl groups, unsubstituted isopropylpyridyl groups, substituted (2-methyl-2-butyl) pyridyl groups, unsubstituted (2-methyl-2-butyl pyridyl) groups, substituted (3-methyl-3-pentyl) pyridyl groups, and unsubstituted (3-methyl-3-pentyl) pyridyl groups, substituted (3-ethyl-3-pentyl) pyridyl groups and unsubstituted (3-ethyl-3-pentyl) pyridyl groups, A′ is a substituted isoquinolinyl group or unsubstituted isoquinolinyl group or an unsubstituted quinolinyl group, A″ is a substituted quinolinyl group, B, B′ and B″ are each, independently, a substituted or unsubstituted bridged cyclic structure of up to 30 carbon atoms of the formula -L-(ML q is an integer of from 1-3, and each cyclic structure of L and L subject to the provisos that B is not and B′ is not wherein the substituents for A″ and the substituted isoquinolinyl groups of A′ are selected from the group consisting of halogen, up to per-halo, and Wn, where n is 0-3 and each W is independently selected from the group consisting of C wherein the substitutents for the substituted t-butyl pyridyl groups substituted trifluoromethyl pyridyl groups, substituted isopropyl pyridyl groups, substituted 2-methyl-2-butyl pyridyl groups and substituted 3-methyl-3-pentyl pyridyl groups of A are selected from the group consisting of halogen, up to per-halo, and Zn, where n is 0-3 and each Z is independently selected from the group consisting of C where B and B′ are substituted, the substituents are selected from the group consisting of halogen, up to per-halo, and Jn, where n is 0-3 and each J is independently selected from the group consisting of —CN, —CO where B″ is substituted, the substituents are selected from the group consisting of halogen, —CN, —C(O)NR subject to the proviso that where B, B′ or B″ is -L(ML where J is a substituted group, it is substituted by halogen, up to per halo, or by one or more substituents independently selected from the group consisting of —CN, —CO