Patent ID: 6103501
Filing Date: 2000-08-15
Classification: A61K,C07K

Abstract:
A glycosylated or nonglycosylated protein having agonist and/or antagonist activity of the formula.beta..sup.1 -(linker.sup.1).sub.m -.alpha.-(linker.sup.2).sub.n -.beta..sup.2 ( 1);or.beta..sup.1 -(linker.sup.1).sub.m -.beta..sup.2 -(linker.sup.2).sub.n -.alpha. (2);or.alpha.-(linker.sup.1).sub.m -.beta..sup.1 -(linker.sup.2).sub.n -.beta..sup.2 ( 3)wherein each of .beta..sup.1 and .beta..sup.1 has the amino acid sequence of the .beta. subunit of a vertebrate glycoprotein hormone which is selected from the group consisting of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), leutinizing hormone (LH) and chorionic gonadotrophin (CG) or a variant thereof which variant binds to the receptor for said .beta.-subunit;"".alpha."" designates the .alpha. subunit of a vertebrate glycoprotein hormone TSH, FSH, LH or CG or a variant thereof;""linker"" refers to a covalently linked moiety that spaces the .beta..sup.1 and .beta..sup.2 subunits at distances from the .alpha. subunit and from each other effective to retain said activity, andeach of m and n is independently 0 or 1;wherein said agonist and/or antagonist activity is with respect to the receptor for which at least one of said .beta. subunits is a ligand.