Patent ID: 7449603
Filing Date: 2008-11-11
Classification: C07B,C07C

Abstract:
1. A process for preparing cinacalcet, comprising: a) reducing 3-trifluoromethyl cinnamic acid to obtain 3-[3-(trifluoromethyl) phenyl]propanoic acid; b) optionally, converting the 3-[3-(trifluoromethyl)phenyl]propanoic acid into a compound of formula III c) converting the 3-[3-(trifluoromethyl)phenyl]propanoic acid into N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl]propanamide, or combining the compound of formula III with (R)-1-naphthylethyl amine in the presence of a base to obtain N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl]propanamide; and d) reducing the N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl propanamide to obtain cinacalcet, wherein X is carboxyl, alkoxy, halogen, or sulfonyl.