Patent ID: 6417195
Filing Date: 2002-07-09
Classification: C07B,C07D,C40B

Abstract:
A combinatorial library of two or more compounds of the formula: wherein:R1 is selected from the group consisting of the structure â€ƒand the structure â€ƒwherein R10 is attached to each of the four carbon ring atoms and is, independently, selected from the group consisting of a hydrogen atom, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 phenylalkyl and C7 to C12 substituted phenylalkyl; and R11 is selected from the group consisting of a hydrogen atom, C1 to C6 alkyl, C1 to C6 substituted alkyl, C2 to C7 alkenyl, C2 to C7 substituted alkenyl, C2 to C7 alkynyl, C2 to C7 substituted alkynyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C12 phenylalkyl, C7 to C12 substituted phenylalkyl, heterocyclic ring and substituted heterocyclic ring; R2 is selected from the group consisting of a hydrogen atom, C1 to C6 alkyl, C1 to C6 substituted alkyl, C2 to C7 alkenyl, C2 to C7 substituted alkenyl, C2 to C7 alkynyl, C2 to C7 substituted alkynyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C7 to C12 phenylalkyl, C5 to C7 cylcoalkenyl, C5 to C7 substituted cycloalkenyl, C7 to C12 substituted phenylalkyl and a heterocyclic ring; R3 R4, R5 and R6 are, independently, selected from the group consisting of a hydrogen atom, halo, hydroxy, protected hydroxy, cyano, nitro, C1 to C6 alkyl, C2 to C7 alkenyl, C2 to C7 alkynyl, C1 to C6 substituted alkyl, C2 to C7 substituted alkenyl, C2 to C7 substituted alkynyl, C1 to C7 alkoxy, C1 to C7 acyloxy, C1 to C7 acyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, a heterocyclic ring, C7 to C12 phenylalkyl, C7 to C12 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted Cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, carboxamide, protected carboxamide, C1 to C4 alkylthio, C1 to C4 alkylsulfonyl, C1 to C4 alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl and substituted phenylsulfonyl; R7 and R9 are, independently, absent or present and, if present, are selected from the group consisting of C1 to C6 alkylene and C1 to C6 substituted alkylene; R8 is absent or present and, if present, is selected from the group consisting of C1 to C6 alkylene, C1 to C6 substituted alkylene, C2 to C7 alkenylene, C2 to C7 substituted alkenylene, C2 to C7 alkynylene, C2 to C7 substituted alkynylene, C3 to C7 cycloalkylene, C3 to C7 substituted cycloalkylene, C5 to C7 cycloalkenylene, C5 to C7 substituted cycloalkenylene, phenylene, substituted phenylene, naphthylene, substituted naphthylene, heterocyclene and substituted heterocyclene; X is selected from the group consisting of hydroxy, protected carboxy, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, an amino acid, aniline, substituted aniline and an amino-substituted heterocyclic ring; Y is selected from the group consisting of CO2H, CH2OH, SH, CH2NHR12, C(O)NHR12 and CH2NHR12, wherein R12 is selected from the group consisting of a hydrogen atom, C1 to C6 alkyl, C1 to C6 substituted alkyl and a functionalized resin; and Z is selected from the group consisting of &boxH;O and H2; or a salt of said compound.