Patent ID: 7407654
Filing Date: 2008-08-05
Classification: A61P,C12P

Abstract:
1. An isolated antibiotic GE 81112 Factor A comprising the following characteristics: A) Mass spectrum recorded from a 0.01 mg/ml solution in acetonitrile: water 50:50 giving a monoprotonated ion at 644 m/z on a Thermofinnigan® LCQ deca mass spectrum instrument under the following electrospray conditions: Spray Voltage: 4.7 kV; Capillary temperature: 250° C.; Capillary Voltage 9V; Infusion mode 5 μl/min; B) Infrared Spectrum recorded as a nujol mull with an IFS-48® Fourier Transform infrared spectrophotometer showing the following main bands (cm C) D) E) Retention time 14.1 min, determined by using an analytical HPLC pump Shimadzu® LC10-AS equipped with a chromatographic column Altima® RP18, 5 μm, 250×4.6 mm i.d column; isocratic elution performed at 1 ml/min. flow rate, with 40 mM ammonium formate buffer, brought to pH 4.5 by addition of formic acid; UV detection at 230 nm; F) possesses acid functions and basic functions; and G) inhibits the growth of wherein the antibiotic GE 81112 Factor A also includes one or more corresponding salts formed with acids and/or bases.