Patent ID: 7807840
Filing Date: 2010-10-05
Classification: C07B,C07D

Abstract:
1. A process for preparing an optically active aminopentane derivative represented by formula (8): wherein Ar represents phenyl, thienyl, naphthyl, benzofuryl, benzothienyl, methylenedioxyphenyl or indolyl which may have a substitution of C1 to C3 alkyl group, and * indicates the position of an asymmetric carbon atom in the R or S configuration, said process comprising the steps of: i) treating an optically active oxathiazolidine derivative represented by formula (5-2): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, to react with an aryl lithium represented by formula (6): wherein Ar has the same meaning as defined above, to obtain an optically active lithium N-sulfonate derivative represented by formula (7): wherein Ar and * each has the same meaning as defined above, and ii) hydrolyzing the optically active lithium N-sulfonate derivative represented by formula (7) to hydrolyze with an acid.