Patent ID: 6514975
Filing Date: 2003-02-04
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, whereinR1 is H, C2-C6 alkanoyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C3-C7 cycloalkyl)-(C1-C4 alkyl), (C1-C4 alkoxy)-(C1-C4 alkyl), carboxy-(C1-C4 alkyl), aryl-(C1-C4 alkyl) or heteroaryl-(C1-C4 alkyl); R2 and R3 are each independently H or C1-C4 alkyl; R4 is selected from (i) H (ii) a group of the formula R6â€”(CH2)mâ€”Zâ€”(CH2)nâ€”, where m is 0, 1, 2 or 3, n is 1, 2 or 3, Z is a direct link or O, and R6 is â€”CO2H or â€”CO2(C1-C4 alkyl), or (iii) a group of the formula where R7 is H or C1-C4 alkyl;and R5 is hydroxy, C1-C4 alkoxy or â€”NHSO2(C1-C4 alkyl); with the proviso that when Z is O, m is 1, 2 or 3 and n is 2 or 3; and wherein (a) â€œarylâ€  is phenyl or naphthyl, both optionally substituted by up to three substituents each independently selected from halo, trifluoromethyl, C1-C4 alkyl and C1-C4 alkoxy, and (b) â€œheteroarylâ€  is thiazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, pyridinyl, pyrimidinyl or pyrazolyl.