Patent ID: 8153646
Filing Date: 2012-04-10
Classification: A61K,A61P

Abstract:
1. A method comprising: (a) providing cognitive training to an animal having a central nervous system disorder or condition under conditions sufficient to produce an improvement in performance by said animal of a cognitive task whose deficit is associated with said central nervous system (CNS) disorder or condition; (b) administering in conjunction with said cognitive training a phosphodiesterase 4 (PDE4) inhibitor that enhances CREB pathway function during said cognitive training; (c) repeating said providing and administering of steps (a) and (b) one or more times; and (d) reducing the number of training sessions sufficient to produce said improvement in performance relative to the improvement in performance produced by cognitive training alone; wherein said phosphodiesterase 4 (PDE4) inhibitor is one or more compounds of Formula I: wherein “Me” means “methyl” and “cPent” means “cyclopentyl” and enantiomers and mixtures thereof.