Patent ID: 8389284
Filing Date: 2013-03-05
Classification: A61K,C12N,C12Y,G01N

Abstract:
1. A method for in vitro screening for a compound which inhibits or decreases the activity of an IGS5 polypeptide having a zinc metallopeptidase activity and comprising an amino acid sequence having a sequence identity of at least 95% when compared to SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:6, the method comprising the steps of: (a) contacting a preparation comprising said IGS5 polypeptide with a candidate compound; and (b) assessing whether the candidate compound results in a inhibition of the activity of the polypeptide, wherein a test compound which decreases or inhibits said activity is identified as a potential agent for the treatment of a CNS disorder or disease and/or a metabolic disorder or disease.