Patent ID: 6828462
Filing Date: 2004-12-07
Classification: A61P,C07C,C07D

Abstract:
A compound selected from those of formula I: wherein:R* is â€”(A)nâ€”(A)nâ€”(CR1R2)mâ€”NR3R4, n+m=0, 1, or 2, A is selected from the group consisting of linear or branched lower alkyl (C1-C6), linear or branched lower alkenyl (C2-C6), and linear or branched lower alkynyl (C2-C6), R1 and R2 are independently selected from the group consisting of hydrogen, linear or branched lower alkyl (C1-C6), linear or branched lower alkenyl (C2-C6), and linear or branched lower alkynyl (C2-C6), R3 and R4 are independently selected from the group consisting of hydrogen, linear or branched lower alkyl (C1-C6), linear or branched lower alkenyl (C2-C6), and linear or branched lower alkynyl (C2-C6), or together form alkylene (C2-C10) or alkenylene (C2-C10) or together with the N form a 3-7-membered azacycloalkane or azacycloallcene, including substituted (alkyl (C1-C6), substituted alkenyl (C2-C6)) 3-7-membered azacycloalkafle or azacycloalkene, R5 is independently selected from the group consisting of linear or branched lower alkyl (C1-C6), linear or branched lower alkenyl (C2-C6), and linear or branched lower alkynyl (C2-C6), or R5 may combine with the carbon atom of W to which it is attached and an adjacent carbon atom of the group R* to form a double bond, or R5 combine with the carbon atom of W to which it is attached and an adjacent ring carbon atom to form a double bond, Rp, Rq, Rr, and Rs are independently selected from the group consisting of hydrogen, linear or branched lower alkyl (C1-C6), linear or branched lower alkenyl (C2-C6), and linear or branched lower alkynyl (C2-C6), or Rp, Rq, Rr, and Rs independently may combine with the carbon to which it is attached and the next adjacent carbon to form a double bond, or Rp, Rq, Rr, and Rs independently may form a double bond with U or with Y to which it is attached, provided that Uâ€”Vâ€”Wâ€”Xâ€”Yâ€”Z is selected from cyclohexane, cyclohex-2-ene, cyclohex-3-ene, cyclohex-1,4-diene, cyclohex-1,5-diene, cyclohex-2,4-diene, and cyclohex-2,5-diene, and provided that at least one of Rp and Rq, are not hydrogen and at least one of Rr, and Rs are not hydrogen, and provided that when U-Z equals cyclohexane, then at least one of â€”(A)nâ€”(CR1R2)m, R3, R4, R5, Rp, Rq, Rr, and Rs is linear or branched lower alkenyl (C2-C6) or linear or branched lower alkynyl (C2-C6), and its optical isomers and pharmaceutically-acceptable acid or base addition salt thereof.