Patent ID: 6399104
Filing Date: 2002-06-04
Classification: A61K,A61P

Abstract:
A dry powder layering process for preparing a pharmaceutical composition which comprises a plurality of pellets, each of said pellets comprising:a) a core; b) a first layer surrounding said core which layer contains amorphous zafirlukast substantially free of other physical forms; and c) a second coating layer which does not contain zafirlukast; each layer optionally comprising other pharmaceutically acceptable ingredients, said process comprising the step of applying in separate feeds (1) amorphous zafirlukast in dry powder form and (2) a binding agent, and each feed optionally adding other pharmaceutically acceptable ingredients to a plurality of cores to form layered pellets, wherein the feed containing the binding agent commences slightly before the feed containing zafirlukast and ends slightly after the feed containing zafirlukast.