Patent ID: 6548061
Filing Date: 2003-04-15
Classification: A61K,A61P

Abstract:
A kit for parenteral administration comprising one or more containers comprising(a) one or more complement-fixing human, recombinant human or humanized antibodies or fragments thereof in a sterile pharmaceutical carrier, wherein said antibodies or fragments comprise a complement-binding Fc region of a complement-fixing antibody which specifically binds to an epitope of a mammalian myelin selected from the group consisting of galactocerebroside (GalC), O4, Myelin Associated Glycoprotein (MAG), NOGO, NI220, NI-35/250, myelin oligodendrocyte glycoprotein (MOG) and arretin; and (b) complement protein in a sterile pharmaceutical carrier; wherein when (a) and (b) are administered together are effective to cause in vivo transient disruption and/or transient demyelination of mammalian neurons.