Patent ID: 6482855
Filing Date: 2002-11-19
Classification: A61K,A61P,A61Q,C07C

Abstract:
A process for the preparation of a compound of formula (I) or an organic or inorganic salt thereof, comprising reacting a salt of an N,Nâ€²-dibenzylalkylenediamine-N,Nâ€²-diacetic acid compound or an N-benzylalkylenediamine-N,Nâ€²,Nâ€²-triacetic acid compound with 2 to 4 equivalents of a substituted halomethyl compound,wherein said compound of formula (I) is chosen from: wherein:R1, R2 and R3 are, independently of one another, chosen from H, OH and linear and branched C1-C8 alkoxy radicals; R4 and R5 are, independently of one another, chosen from H and linear and branched C1-C4 alkyl radicals, it being possible for R4 and R5, taken together, to form a 5- or a 6-membered ring; X1 and X2 are, independently of one another, chosen from â€”(CO)NR6R7 groups in which R6 and R7 are, independently of one another, chosen from H and linear and branched C1-C4 alkyl radicals; it being possible for R6 and R7, taken together, to form a 5- or a 6-membered ring, and â€”O(CO)R8 groups in which R8 is chosen from H and linear and branched C1-C8 alkyl radicals; Z is chosen from compounds of formula (II) and formula (III) in which:Râ€²1, Râ€²2 and Râ€²3 are, independently of one another, chosen from H, OH, and linear and branched C1-C8 alkoxy radicals; Xâ€² is chosen from â€”(CO)NRâ€²4Râ€²5 groups in which Râ€²4 and Râ€²5 are, independently of one another, chosen from H and linear and branched C1-C4 alkyl radicals; it being possible for Râ€²4 and Râ€²5, taken together, to form a 5- or a 6-membered ring, and â€”O(CO)Râ€²6 groups in which Râ€²6 is chosen from H and linear and branched C1-C8 alkyl radicals.