Patent ID: 6022892
Filing Date: 2000-02-08
Classification: A61P,C07C,C07F,Y02P

Abstract:
A bis-platinum(II) complex comprising formula (I): whereintwo of the X,Y, and Z ligands attached to each platinum atom are ammonia and the other ligand is selected from the group consisting of chloride, bromide, iodide, and a (C.sub.1 -C.sub.4)acyloxy group;n and m are each independently an integer of two to eight;p is one or two;A is selected in the group consisting of --B--,--B--(CH.sub.2).sub.r --B--, --B--(CH.sub.2).sub.r --B--(CH.sub.2).sub.z --B--, wherein r and z are an integer ranging of two to eight, B is a group --NR.sup.1 -- or --N(R.sup.2).sup.+ 1/pQ.sup.-p, which R.sup.1 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)acyl, tert-butyloxycarbonyl, and R.sup.2 is selected in the group consisting of hydrogen, (C.sub.1 -C.sub.4)alkyl; andQ.sup.--p is an anion selected from chloride, bromide, iodide, nitrate, sulfate, hydrogensulfate, perchlorate.