Patent ID: 7122646
Filing Date: 2006-10-17
Classification: A61K,C07K,C12N

Abstract:
1. A nucleic acid molecule comprising a nucleotide sequence encoding a first polypeptide and a nucleotide sequence encoding a second polypeptide, wherein said first polypeptide comprises a first domain which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain which comprises a binding region of an immunoglobulin light chain variable region, the first and second domains of the first polypeptide being linked by a polypeptide linker; and said second polypeptide comprises a first domain which comprises a binding region of an immunoglobulin heavy chain variable region, a second domain which comprises a binding region of an immunoglobulin light chain variable region, the first and second domains of the second polypeptide being linked by a polypeptide linker; the first domain of the first polypeptide and the second domain of the second polypeptide associating to form a first antigen binding site; and the second domain of the first polypeptide and the first domain of the second polypeptide associating to form a second antigen binding site; said first antigen binding site being different from said second antigen binding site; and the polypeptide linker of the first polypeptide is of a length such that said first and second domains of said first polypeptide are incapable of associating with each other to form an antigen binding site.