Patent ID: 6107102
Filing Date: 2000-08-22
Classification: A61K,B01J,Y10S

Abstract:
A suspension of microdevices for use in delivering a therapeutic compound to the interstitial space of a target region which is characterized by a target-specific marker on a basement membrane forming a vasculature of the target region, comprisinga suspension of microdevices in an aqueous medium, said microdevices (i) having a selected non-spherical shape, uniform dimensions and a selected maximum dimension in a range of 0.1 and 3 microns and (ii) composed of at least two separate bodies, including a support having at least one planar surface, and a therapeutic agent attached to the support, said therapeutic agent being in a form such that the activity of the therapeutic agent is expressed in direct response to a chemical or biochemical interaction that occurs upon exposure of the microdevice to a biochemical environment of a target site after administration of the microdevices to a subject, said microdevices containing a surface-bound marker-binding molecule effective to bind to such marker, and an enzyme effective to lyse the basement membrane.