Patent ID: 6057313
Filing Date: 2000-05-02
Classification: C07D

Abstract:
A nitrogen substituted azacycloalkyl ring fused 2,3 quinoxalinedione compound represented by the formula: ##STR94## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or W-alkyl;X and Y are independently hydrogen, halogen, nitro, cyano, trifluoromethyl, SO.sub.2 CF.sub.3, SO.sub.2 R.sup.4, SO.sub.2 NR.sup.4 R.sup.5, alkyl, alkenyl, (CH.sub.2).sub.z CONR.sup.4 R.sup.5, (CH.sub.2).sub.z COOR.sup.4, or NHCOR.sup.4, wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl having 1 to 6 carbon atoms, cycloalkyl or W-alkyl, and z is an integer from 0 to 4;R.sup.2 is benzoyl, W, W-alkyl, COcycloalkyl, COalkyl-W, CONR.sup.3 alkyl, CONR.sup.3 -W, CONR.sup.3 alkyl-W, CSNR.sup.3 alkyl, CSNR.sup.3 alkyl-W, ##STR95## or a moiety derived from a common amino acid by removal of the --OH from the carboxyl group which is alpha to the amino, wherein R.sup.3 is hydrogen, alkyl or W-alkyl and wherein W is phenyl, naphthyl, thienyl, furyl, tetrazolyl, pyrrolyl, pyrimidinyl, triazolyl, imidazolyl, piperidyl, piperazinyl, morpholinyl or pyrrolinyl;and m and n are independently 0, 1 or 2 provided that m+n is >1;provided that when R.sup.2 is benzoyl, ##STR96## X is nitro, Y and R.sup.1 are H, m is 2 and n is 1; where R.sup.2 is ##STR97## X is nitro, Y and R.sup.1 are H, and m is 2 and n is 1; or when R.sup.2 is ##STR98## X is bromo, Y and R.sup.1 are H, m is 1 and n is 2.