Patent ID: 6472548
Filing Date: 2002-10-29
Classification: C07B,C07C

Abstract:
A process for the preparation of a complex of the formulaLÂ·BÂ·M wherein(a) L is an amino acid derivative including two optically active amino acids linked by a (CH2)n group, wherein the (CH2)n group is attached to a nitrogen of each optically active amino acid, said optically active amino acid may be the same or different; and wherein n is an integer from 1 to 10, (b) B is a base and (c) M is a metal, the process comprising the steps of (i) providing a reaction mixture comprising L and B and having a pH of less than 7.5; (ii) contacting the reaction mixture with M to provide a first complex mixture; (iii) contacting the first complex mixture with a further amount of B to provide a second complex mixture; and (iv) sequentially contacting the second complex mixture with further amounts of M and further amounts of B.