Patent ID: 6376685
Filing Date: 2002-04-23
Classification: C07C,C07D

Abstract:
A process for producing an optically active threo-3-amino-1,2-epoxy compound represented by the formula(3), where R1 is a C3-C12 hydrocarbon residual group; R2 is an amino group or a protected amino group; *2 is, if *3 is S in configuration, R in configuration and, if *3 is R in configuration, S in configuration, which comprises reacting the optically active threo-3-amino-1,2-diol derivative represented by the formula(1) where R1, R2, *2 and *3 show the same meanings as described above, with an alkylsulfonyl halogenide or an arylsulfonyl halogenide for sulfonylating under the presence of a base in an organic solvent to obtain site-specifically the optically active threo-3-amino-2-hydroxysulfonate derivative represented by the formula(2) where R1, R2, *2 and *3 show the same meanings as described above, and R3 is a C1-C12 hydrocarbon residual group, and then epoxydating, without isolating from the organic phase, under the presence of a base.