Patent ID: 6528676
Filing Date: 2003-03-04
Classification: A61K,A61P,C07J,Y10S

Abstract:
A compound of the formula: wherein:I. Ra-Ro are defined as follows: A) each Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Rj, Rk, RL, Rm, Rn, Ro independently is â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR2, â€”Br, or â€”I; and Ri is â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR2, â€”Br, â€”I or â€”Câ‰¡CH; or B) each Ra, Rd, Rf, Rj, Rm, Rn, Ro independently is â€”R1, â€”OR1, â€”OCR1, â€”SR1, â€”F, â€”NHR2, â€”Br, â€”I; and each Rb, Rc, Re, Rg, Rh, Rk independently is &boxH;O, â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR1, â€”Br or â€”I; RL independently is â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR1, â€”Br or â€”I; and Ri is &boxH;O, â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR1, â€”Br, â€”I or â€”Câ‰¡CH; or C) each Ra, Rb, Rc, Rd, Rf, Rj, Rm, Rn, Ro independently is â€”R1, â€”OR1, â€”OCR1, â€”SR1, â€”F, â€”NHR2, â€”Br, â€”I; and each Re, Rg, Rh, Rk independently is &boxH;O, R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR1, â€”Br or â€”I; RL independently is â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”NHR1, â€”Br or â€”I; and Ri is &boxH;O, â€”R1, â€”OR1, â€”OCOR1, â€”SR1, â€”F, â€”HNR1, â€”Br, â€”I or â€”Câ‰¡â€”CH; and II. Z is defined as follows: â€ƒis â€”R1, â€”OR1, â€”SR1, â€”F, â€”NHR2, â€”Br or â€”I; and Xâ€² is X, as defined above; or Xâ€² is >C&boxH;O; where, in each formula set forth above, each R1 and R2 independently is â€”H, or an alkyl, alkenyl or alkynl group of up to 6 carbons; and the bond indicated by Câ€” â€” â€”C is absent or, in combination with the Câ€”C bond is the unit HC&boxH;CH.