Patent ID: 6372940
Filing Date: 2002-04-16
Classification: C07C

Abstract:
A process for the preparation of a stable, non-hygroscopic salt of L(âˆ’)-carnitine selected from the group consisting of L(âˆ’)-carnitine acid fumarate (1:1) and L(âˆ’)-carnitine L(+)-tartrate (2:1), comprising:a) mixing at room temperature, in any desired order, (1) L(âˆ’)-carnitine inner salt; (2) fumaric acid or L(+)-tartaric acid, respectively in equimolar amount or in half the equimolar amount to L(âˆ’)-carnitine inner salt; and (3) 5-9%, preferably 6-8%, by weight of water calculated on the weight of the (1)+(2)+(3) mixture; (b) heating under stirring the above mixture at a temperature of 100-120Â° C. to obtain a substantially colourless, transparent molten mass; (c) cooling the molten mass until complete solidification; and (d) grinding the solidified mass to obtain a granulate or powder having the desired particle size.