Patent ID: 7005520
Filing Date: 2006-02-28
Classification: C07D

Abstract:
1. A process for the production of a compound of formula I: wherein A represents CH or N; R R R Het represents an optionally substituted four- to twelve-membered heterocyclic group, which group contains one or more heteroatoms selected from nitrogen, oxygen and sulfur; R R which process comprises the reaction of a compound of formula II, wherein R —OR —N H —NHR —N(R —SH; and —SR and A, R 3 and R 4 are as defined above, with a compound of formula III, wherein R 1 and R 2 are as defined above and wherein the compound of formula II is prepared by way of reaction of a compound of formula IV, wherein G represents a carboxylic acid group (—C(O)OH), CO 2 Et, —CN, —C(OR e ) 3 , —C(O)NH 2 , —C(═NOR f )N(R e ) 2 , wherein R f represents H or lower alkyl and R e is as hereinbefore defined, 5- or 6-membered heterocyclic group containing at least two heteroatoms selected from O, S, N and mixtures thereof wherein the heterocyclic group is bonded by a carbon atom wherein the group G is converted to a —C(R x )═NH group.