Patent ID: 8198417
Filing Date: 2012-06-12
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A cell-binding agent maytansinoid conjugate having at least one thiol-containing maytansinoid linked to a cell-binding agent via a non-cleavable linker, wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically bind to a target cell, wherein the antibody, single chain antibody or antibody fragment comprises a human constant region and wherein the non-cleavable linker is a linker that is substantially resistant to acid-induced cleavage, light-induced cleavage, peptidase-induced cleavage, esterase-induced cleavage, and disulfide bond cleavage, provided that the cell-binding agent is not an anti-erbB antibody.