Patent ID: 7611853
Filing Date: 2009-11-03
Classification: G01N,Y02A,Y10S,Y10T

Abstract:
1. An assay to screen anti-malarial drugs by testing for binding of a test compound with plasmodium 90 kDa heat shock protein which comprises: (a) immobilizing said test compound covalently on a matrix thereby forming an immobilized test compound; (b) reacting saponin-freed Plasmodial trophozoite lysate comprising plasmodium 90 kDa heat shock protein with said immobilized test compound; (c) detecting binding of plasmodium 90 kDa heat shock protein to said immobilized test compound; (d) selecting said test compound if binding between said plasmodium 90 kDa heat shock protein and said immobilized test compound is detected in step (c); (e) measuring growth of (f) comparing the growth of (g) detecting a decrease in said measured growth of