Patent ID: 6232475
Filing Date: 2001-05-15
Classification: C07C,C07D

Abstract:
A process for preparing fluorine-containing phenethylamines of the formula ##STR17##in which one of the radicalsR.sup.1 and R.sup.2 represents fluorine, trifluoromethyl, trifluoromethoxy, tetrafluoroethoxy or pentafluoroethoxy and the other represents hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, fluorine, trifluoromethyl, trifluoromethoxy, tetrafluoroethoxy or pentafluoroethoxy orR.sup.1 and R.sup.2 together represent --O--CF.sub.2 --O--, --O--CF.sub.2 --CF.sub.2 -- or --O--CF.sub.2 --CF.sub.2 --O-- andR.sup.3 represents hydrogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy,in which in a first step a substituted bromobenzene of the formula ##STR18##in whichR.sup.1, R.sup.2 and R.sup.3 are each as defined under formula (I)is reacted with an N-vinylimide of the formula ##STR19##in whichA represents --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --C(CH.sub.3).sub.2 --CH.sub.2 --, --CH.sub.2 --O--CH.sub.2 --, --CH.dbd.CH-- or o-phenylene,in the presence of a palladium catalyst, to produce .beta.-iminovinylbenzene of the formula ##STR20##in whichthe radicals R.sup.1, R.sup.2 and R.sup.3 are each as defined under formula (I) and the radical A is as defined under formula (V)is, in a second step, hydrogenated with catalyst and, in a third step, the substituted .beta.-iminoethylbenzene of the formula ##STR21##in whichR.sup.1, R.sup.2 and R.sup.3 are each as defined under formula (I) andA is as defined under formula (V),the imide moiety, is cleaved.