Patent ID: 6465501
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of formula I having the structure wherein, R1, R2, R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aryl of 6 to10 carbon atoms, aryloxy of 6-10 carbon atoms, halogen, trifluoromethyl of 1-6 carbon atoms, arylaikoxy of 7-14 carbon atoms, arylalkyl of 7-14 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, nitro, amino, aminocarbonyl, alkylamino of 1-6 carbon atoms, dialkyl amino of 1-6 carbon atoms per alkyl group, formamido, ureido, acyl of 2-7 carbon atoms, acylamino of 2-7 carbon atoms, amino, alkylsulfonylamino of 1-6 carbon atoms, or arylsulfonylamino of 6 to 10 carbon atoms; or two of R1, R2, and R3 are taken together to form a phenyl ring or a heterocyclic ring which is fused to the ring which contains the R1, R2, or R3 substituents, wherein the heterocyclic ring contains 1-3 heteroatoms selected from N, O, or S; R4 is hydrogen or alkyl of 1-6 carbon atoms; R5 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, arylalkyl of 7-14 carbon atoms, halogen substituted arylalkyl of 7-14 carbon atoms, arylalkene of 8-16 carbon atoms, arylalkyne of 8-16 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, aryloxycarbonyl of 7-11 carbon atoms, alkylsulfonyl of 1-6 carbon atoms, or arylsulfonyl of 1-6 carbon atoms; R6 is hydrogen, alkyl of 1-6 carbon atoms, aryl or arylalkyl of 7-14 carbon atoms; A is phenyl, naphthyl, benzofuryl, or benzothienyl; X is bond, â€”OCH2â€”, or â€”SCH2â€”; Y is alkyl of 1-6 carbon atoms, or alkoxy of 1-6 carbon atoms; Z is sulfur; W is carbon; or a pharmaceutically acceptable salt thereof.