Patent ID: 6429298
Filing Date: 2002-08-06
Classification: C07K,C12N,C12Q

Abstract:
A polynucleotide encoding a thermostable p53 polypeptide comprising a first point mutation selected from the group consisting of Val133, Tyr239, Asp268, Val336, Pro364, Val62, Thr116, Pro166, Thr270, Ser88, Ile157, Val344, Gly42, Ser268, Lys51, Gly326, Glu207, Ser212, His264, Ala203, Leu80, Ala30, Lys56, Asn106, Arg115, Ser227, Met344, Gln45, Ala102, Ser191, Thr322, Ala31, Gly49, Thr183, Ile264 and Val346, wherein the noted amino acid position is in reference to SEQ ID NO:2.