Patent ID: 7534761
Filing Date: 2009-05-19
Classification: A61K,B82Y,C07K,Y10S

Abstract:
1. A peptide amphiphile composition comprising: a hydrophobic component having a single alkyl group greater than six carbons in length; and a hydrophilic component selected from the group consisting of CCCCGGGSS*DS*D (SEQ ID NO:1), AAAAGGGSS*DS*D (SEQ ID NO:2), SLSLGGGSS*DS*D (SEQ ID NO:3), CCCCGGGS*S*DS*D (SEQ ID NO:4), AAAAGGGS*S*DS*D (SEQ ID NO:5), SLSLGGGS*S*DS*D (SEQ ID NO:6), CCCCGGGDSS*DS* (SEQ ID NO:7), AAAAGGGDSS*DS* (SEQ ID NO:8), SLSLGGGDSS*DS* (SEQ ID NO:9), CCCCGGGDS*S*DS* (SEQ ID NO:10), AAAAGGGDS*S*DS* (SEQ ID NO:11), SLSLGGGDS*S*DS* (SEQ ID NO:12), CCCCGGGSDS*DS* (SEQ ID NO:13), AAAAGGGSDS*DS* (SEQ ID NO:14), SLSLGGGSDS*DS* (SEQ ID NO:15), CCCCGGGS*DS*DS* (SEQ ID NO:16), AAAAGGGS*DS*DS* (SEQ ID NO:17), SLSLGGGS*DS*DS* (SEQ ID NO:18), CCCCGGGDS*DS*D (SEQ ID NO:19), AAAAGGGDS*DS*D (SEQ ID NO:20), and SLSLGGGDS*DS*D (SEQ ID NO:21), wherein S* is phosphorylated serine, wherein said hydrophilic component is covalently bonded to said hydrophobic component in said peptide amphiphile, said hydrophilic component having a net charge at physiological pH, and wherein said peptide amphiphile self-assembles to form a cylindrical micelle.