Patent ID: 6596545
Filing Date: 2003-07-22
Classification: B82Y,Y10S,Y10T

Abstract:
A multi-channel sample detection device, comprising(a) a substrate having an upper surface; (b) a plurality of open channels formed in or on said substrate adjacent said upper surface, each channel extending between first and second ends and having a bottom wall surface defining a substantially planar immobilization region intermediate the first and second ends; (c) a transparent cover attached to said substrate and forming with each channel a closed channel having open first and second ends, where the first ends of the channels are linearly aligned so that said channels can each be both independently loaded with a fluid having a fluid surface and containing one or more analytes or simultaneously loaded with said fluid by simultaneously placing said aligned first open ends of said channels in contact with said fluid surface; (d) a thinfilm having a hydrophilic display surface, and covering each immobilization region, said thinfilm being effective to resist non-specific protein binding; and, (e) a plurality of immobilization groups for immobilizing selected proteins or peptides or small molecules, said immobilization groups being attached to said thinfilm in each channel; wherein when said liquid containing said one or more analytes is introduced into said channels to interact with said peptides or proteins or small molecules, such interactions, if any, can be observed through said transparent cover.