Patent ID: 9216956
Filing Date: 2015-12-22
Classification: A61K,A61P,C07D

Abstract:
1. A method of preparing a deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide, or a pharmaceutically acceptable salt thereof, comprising reacting a C1-C4 alkyl ester of 4-hydroxy-5-methoxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid with deuterium-enriched N-methyl-p-trifluoromethylaniline, wherein the N-methyl group has a deuterium enrichment of at least 70%.