Patent ID: 8404729
Filing Date: 2013-03-26
Classification: A61P,C07D

Abstract:
1. Compound according to Formula (I) an N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein: n is an integer, equal to zero; 1; 2; 3; 4; 5 or 6; i, j are integers, independently from each other, equal to zero; 1; 2; 3 or 4; r is an integer, equal to zero; 1; 2; 3 or 4; R wherein: p is an integer equal to zero; 1; 2; 3 or 4; q is an integer equal to 1 or 2; m is an integer equal to zero; 1; 2 or 3; each R R each R one of A or B is benzene and the other is thiophene; each R Y is selected from this group consisting of O; S; S(═O); and S(═O) X is CR R R aryl is phenyl or naphthyl, each optionally substituted with 1, 2 or 3 substituents selected from the group consisting of halo; nitro; cyano; hydroxy; alkyloxy and alkyl; alkyl is selected from the group consisting of a straight or branched saturated hydrocarbon radical having from 1 to 10 carbon atoms, a cyclic saturated hydrocarbon radical having from 3 to 8 carbon atoms and a saturated hydrocarbon radical containing a straight or branched moiety having from 1 to 10 carbon atoms and a cyclic moiety having from 3 to 8 carbon atoms; each radical optionally substituted with one or more substituents selected from the group consisting of halo; cyano; oxo; hydroxy; formyl; carboxyl and amino radicals; alkenyl is selected from the group consisting of a straight or branched unsaturated hydrocarbon radical having from 1 to 6 carbon atoms, and a cyclic unsaturated hydrocarbon radical having from 3 to 6 carbon atoms; said radical having one or more double bonds and said radical being optionally substituted with one or more substituents selected from the group consisting of halo; cyano; oxo; hydroxy; formyl; carboxyl and amino radicals; and halo is selected from the group consisting of fluoro; chloro; bromo and iodo.