Patent ID: 6670335
Filing Date: 2003-12-30
Classification: A61K,A61Q

Abstract:
A topical formulation containing fluorouracil, comprising:(i) an oil-in-water emulsion; and (ii) dispersed within the oil-in-water emulsion, (a) fluorouracil; and (b) fluorouracil-impregnated porous microparticles, where the formulation has a total fluorouracil content that the sum of the fluorouracil in (ii)(a) and the fluorouracil in the fluorouracil-impregnated porous microparticles of (ii)(b) of from about 0.01% to about 10% by weight and a free fluorouracil content that is the fluorouracil in (ii)(a) of from 20% to 50% by weight of the total fluorouracil content.