Patent ID: 6749867
Filing Date: 2004-06-15
Classification: A61K

Abstract:
A solid dosage form that provides a delayed and subsequently rapid release of omeprazole into an environment of use, wherein the dosage form comprises:a core comprising omeprazole and at least one pharmaceutical excipient, wherein the core rapidly releases the omeprazole after the core is contacted with a fluid in an environment of use; and a time-release non-enteric water soluble or water erodible coating surrounding and in contact with the core, wherein the coating delays the contact of the core with a fluid in an environment of use for a sufficient period of time to delay the release of the omeprazole from the core, and the coating loses its physical integrity in an essentially pH independent manner after the delay thereby permitting the core to rapidly release the omeprazole into the environment of use; and wherein, the dosage form excludes an enteric release coating made from an enteric release polymer; the dosage form is adapted for oral administration; the time-release coating is sufficiently thick to retain its chemical and physical integrity in the stomach when administered orally; and the time-release coating loses its physical integrity in the upper portion of the GI tract downstream from the stomach thereby releasing omeprazole.