Patent ID: 6133251
Filing Date: 2000-10-17
Classification: A61K,A61P,Y10S

Abstract:
A combination preparation for contraception comprising a first stage consisting of from 2 to 4 first stage daily dosage portions, a second stage consisting of two groups of second stage daily dosage portions, a third stage consisting of from 2 to 4 third stage daily dosage portions and an additional stage consisting of from 2 to 4 additional stage daily dosage portions;wherein said first stage daily dosage portions each consist of an effective amount of at least one natural estrogen, said second stage daily dosage portions of said first group and said second group each consist of an effective amount of a combination of said at least one natural estrogen and at least one natural or synthetic gestogen, said third stage daily dosage portions each consist of an effective amount of said at least one natural estrogen and said additional stage daily dosage portions each consist of a pharmaceutically acceptable placebo;wherein said first group of said second stage consists of 3 to 5 of said second stage daily dosage portions, said second group of said second stage consists of 13 to 17 of said second stage daily dosage portions and said second stage daily dosage portions each include more of said at least one synthetic or natural gestogen in said second group than in said first group;wherein said effective amount of said at least one natural estrogen is constant in said first stage and also constant in said third stage but said effective amount in said third stage is smaller than said effective amount in said first stage; andwherein said at least one natural estrogen is selected from the group consisting of estradiol, conjugated equine estradiol and estradiol compounds that are metabolized to form estradiol when taken into the body.