Patent ID: 6242435
Filing Date: 2001-06-05
Classification: A61K,A61P,A61Q

Abstract:
A composition comprising a vitamin D analog and a retinoid, wherein:(a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and(b) the retinoid is selected from the group consisting of retinoid D with an alcohol CH.sub.2 OH terminal side chain, an ester of retinoid D having an ester bond, an ether of retinoid D having an ether bond, and retinoid D where the alcohol CH.sub.2 OH terminal side chain is replaced with an aldehyde CHO terminal side chain, wherein each of the ester bond and the ether bond is formed with the oxygen at the terminal side chain of Retinoid D and wherein retinoid D with the alcohol CH.sub.2 OH terminal side chain has the structure: ##STR13##wherein R.sub.1 is selected from the group consisting of ##STR14##wherein the keto group at the 4-position is free or protected, or is replaced by a thioketone group which is free or protected or is replaced by C.sub.1-6 -alkylidene group; ##STR15##wherein X is selected from the group consisting of hydrogen and C.sub.1-6 -alkyl and Y is selected from the group consisting of C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino and wherein the absolute configuration at the 4-position is independently R or S; ##STR16##wherein X.sub.1, Y.sub.1 are independently selected from the group consisting of hydrogen, C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino and Z.sub.1 is selected from the group consisting of C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino; ##STR17##wherein X.sub.2 is selected from the group consisting of hydrogen, C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino and Z.sub.2 is selected from the group consisting of C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino; and ##STR18##wherein X.sub.3 and Y.sub.3 are independently selected from the group consisting of hydrogens, C.sub.1-6 -alkyl, hydroxyl, alkoxyl, acyloxyl, halide, azide, sulfhydryl, amine and C.sub.1-6 -alkyl substituted amino so long as X.sub.3 and Y.sub.3 are not both hydrogens.