Patent ID: 6066632
Filing Date: 2000-05-23
Classification: C07D

Abstract:
A compound of formula I ##STR17## wherein R.sup.1 and R.sup.2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C.sub.1-6 alkyl or C.sub.1-6 -alkoxy;Y is >N--CH.sub.2 -- wherein only the underscored atom participates in the ring system;X is --C(R.sup.6 R.sup.7)--, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--CH.sub.2 --, --CH.sub.2 --CH.dbd.CH--, --CH.sub.2 --(C.dbd.O)--, --(C.dbd.O)--CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH(R.sup.10)CH.sub.2 --, --CH.sub.2 CH(R.sup.10)-- or --(C.dbd.O)--, wherein R.sup.6 and R.sup.7 independently are hydrogen or C.sub.1-6 -alkyl; and wherein R.sup.10 is C.sub.1-6 -alkyl or phenyl;r is 1, 2 or 3; andZ is selected from ##STR18## wherein R.sup.3 is --(CH.sub.2).sub.p COOH wherein p is 2, 3, 4, 5 or 6; ora pharmaceutically acceptable salt thereof.