Patent ID: 8557806
Filing Date: 2013-10-15
Classification: A61K,A61P,C07D,Y10S

Abstract:
1. A method of treating rheumatoid arthritis and/or one or more symptoms associated therewith in a mammal, the method comprising administering to the mammal an effective amount of a compound of formula (I) and one or more additional compounds selected from a steroid, a membrane stabilizer, a 5LO inhibitor, a leukotriene synthesis inhibitor, a leukotriene receptor inhibitor, an inhibitor of IgE isotype switching, an inhibitor of IgE synthesis, an inhibitor of IgG isotype switching, an inhibitor of IgG synthesis, a β-agonist, a tryptase inhibitor, aspirin, a COX inhibitor, methotrexate, an anti-TNF drug, rituxan, a PD4 inhibitor, a p38 inhibitor, a PDE4 inhibitor, and an antihistamine, wherein the compound of formula (I) is: and salts, hydrates, solvates and N-oxides thereof, wherein: L R R wherein at least one of R R R R each R each R each R each R each R each m is independently an integer from 1 to 3; and each n is independently an integer from 0 to 3, wherein one or both of R wherein: p is an integer from one to three; each R X is selected from the group consisting of CH, N and N—O; each Y is independently selected from the group consisting of O, S and NH; each Y each Y R R R A is selected from the group consisting of O, NH and NR R each Z is selected from the group consisting of hydroxyl, alkoxy, aryloxy, ester, and carbamate; Q is selected from the group consisting of —OH, —OR R