Patent ID: 7575762
Filing Date: 2009-08-18
Classification: A61K,A61P

Abstract:
1. A method of manufacturing a composition comprising sustained-release fine particles, said method comprising: providing sustained-release fine particles having controlled dissolution for quick-disintegrating tablets in the buccal cavity, wherein each particle comprises a coated drug over a core selected from the group consisting of microcrystalline cellulose, sodium chloride and silicon dioxide, and further a coating of a polymer substance over the drug; and granulating by intermittent spraying said sustained-release fine particles and one or two or more fillers selected from the group consisting of sugars and sugar alcohols together with a binder for quick-disintegrating tablets in the buccal cavity, and wherein the ratio of ungranulated sustained-release fine particles in the entire composition is 0 to 15% and the coefficient of variation (CV %) of the amount of drug is 3.5% or less, wherein the mean particle diameter of the sustained-release fine particles is approximately 0.1 μm to approximately 350 μm to produce said composition; wherein the binder for quick-disintegrating tablets in the buccal cavity is one or two or more selected from the group consisting of saccharides of high moldability, water-soluble polymer substances, and saccharides with a low melting point, and wherein the sugar or sugar alcohol is one or two or more selected from the group consisting of saccharides with low moldability, saccharides with a high melting point, and saccharides with a low melting point.