Patent ID: 8979797
Filing Date: 2015-03-17
Classification: A61K,A61M,A61P

Abstract:
1. A method for treating or preventing a disease of the pelvic floor in a subject comprising a step of delivering a composition comprising a therapeutic agent selected from the group consisting of nucleic acids and polypeptides to a tissue of the male or female urogenital tract or lower gastrointestinal tract within the subject's body, wherein the tissue is selected from bladder, prostrate, urethral, kidney, vaginal, and endometrial tissues, and wherein the nucleic acid or polypeptide is present in a nanoparticle or microparticle comprising an excipient polymeric material selected from the group consisting of polylactic acid, poly(lactide-co-glycolide), polycaprolactone, polyhydroxybutyrate, polyorthoesters, polyphosphazine, polymethylidenemalonate, polyalkeneanhydrides, polypeptides, and polyanhydrides, where the composition is delivered to the tissue using a pressure in the range of 100 psi to 4000 psi, and therapeutic agent treats or prevents the disease in the tissue.