Patent ID: 7390910
Filing Date: 2008-06-24
Classification: A61P,C07K

Abstract:
1. A compound represented by Formula I: wherein: A is selected from the group consisting of an alkyl moiety of 1 to 10 carbon atoms, alkenyl moiety of 2 to 10 carbon atoms, aryl and a cyclic hydrocarbon moiety of 3 to 10 carbon atoms, wherein carbon atoms may optionally be replaced with 0 to 4 nitrogen atoms, 0 to 4 oxygen atoms, and 0 to 4 sulfur atoms, and the carbon atoms are optionally substituted with: ═O, ═S, —OH, —OR R is selected from the group consisting of H, an alkyl moiety of 1 to 18 carbon atoms, alkenyl moiety of 2 to 18 carbon atoms, aryl and a cyclic hydrocarbon moiety of 3 to 18 carbon atoms, wherein carbon atoms may optionally be replaced with 0 to 4 nitrogen atoms, 0 to 4 oxygen atoms, and 0 to 4 sulfur atoms, and the carbon atoms are optionally substituted with: ═O, ═S, —OH, —OR B′ is O or H E is the moiety or aryl, a 5 to 14-membered monocydic, bicyclic or tricyclic saturated or unsaturated hydrocarbon ring moiety wherein carbon atoms may optionally be replaced with 0 to 4 nitrogen atoms, 0 to 4 oxygen atoms, and 0 to 4 sulfur atoms wherein the carbon atoms may optionally be substituted with: R, ═O, ═S, —OH, —OR R R R R R R R R R R R R D is O or OH; Y is an alkyl moiety of 1 to 10 carbon atoms optionally substituted with R, AryIR-, or X, or an alkenyl moiety of 2 to 10 carbon atoms optionally substituted with R, ArylR-, or X; Z is defined as a moiety selected from the group consisting of: pyrrolidinyl, pyrrolyl and a moiety of formula the dotted line is an optional bond; m is 1; R R R and a moiety of the formula R R X is defined as a moiety selected from the group consisting of: —OH, —OR, ═O, ═S, —O Aryl is defined as an aromatic hydrocarbon moiety having 6, 10 or 14 carbon atoms, optionally substituted with R or Z; Heteroaryl means a 5- or 6-membered heterocyclic ring, which may be fused to another 5- or 6-membered heterocyclic ring, especially heteroaromatic rings which contain 1 to 3 heteroatoms independently selected from 0, N and S optionally substituted with R or X or fused to a cyclic hydrocarbon moiety of 3 to 10 carbon atoms; or pharmaceutically acceptable salts thereof.