Patent ID: 9161977
Filing Date: 2015-10-20
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a skeletal disorder associated with FGFR3 activation and/or expression, the method comprising administering to a subject in need thereof an anti-FGFR3 antagonist antibody comprising: (i) a light chain variable region comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:87, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:88, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:89, and (ii) a heavy chain variable region comprising (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:84, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:85, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:86.