Patent ID: 6221959
Filing Date: 2001-04-24
Classification: A61K,A61P,C08F,C08L

Abstract:
A composition comprising a noncovalent polynucleotide/polymer complex consisting essentially of (i) a polynucleotide and (ii) a polymer of a plurality of covalently bound polymer segments comprising:(a) at least one polycationic homopolymer or copolymer having at least three cationic sites, including the protonated and quaternary forms thereof, and comprising at least one member selected from the group consisting of (i) a cationic amino acid, (ii) a tertiary amino monomer of the formula: ##STR19##and(iii) a secondary amino monomer of the formula: ##STR20##in which:R.sup.1 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;each of R.sup.2 and R.sup.3, taken independently of the other, is the same or different straight or branched chain alkanediyl group of the formula: ##STR21##in which z has a value of from 2 to 8;R.sup.4 is hydrogen satisfying one bond of the depicted geminally bonded carbon atom; andR.sup.5 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;R.sup.6 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;R.sup.7 is a straight or branched chain alkanediyl group of the formula: ##STR22##in which z has a value of from 2 to 8; andR.sup.8 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer; and(b) at least one water-soluble nonionic polymer segment.