Patent ID: 6040322
Filing Date: 2000-03-21
Classification: A61K,A61P

Abstract:
A method for the treatment of an animal, including man, suffering from inappropriate endothelial cell activation, which method comprises administration of a therapeutically effective amount of a compound of formula (I): ##STR4## in which: R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group;R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.6 aliphatic acyl group, a (C.sub.5 -C.sub.7 cycloalkane) carbonyl group, an aromatic acyl group which is a benzoyl or naphthoyl group optionally with one or more nitro, amino, alkylamino, dialkylamino, alkoxy, halo, alkyl or hydroxy substituents, a heterocyclic acyl group having one or more oxygen, sulphur or nitrogen hetero atoms and with 4 to 7 ring atoms, an optionally halo-substituted phenylacetyl or phenylpropionyl group, a cinnamoyl group, a (C.sub.1 -C.sub.6 alkoxy) carbonyl group or a benzoyloxycarbonyl group;R.sup.4 and R.sup.5 are the same or different and each represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or a C.sub.1 -C.sub.5 alkoxy group, or R.sup.4 and R.sup.5 together represent a C.sub.1 -C.sub.4 alkylenedioxy group;n is 1, 2 or 3;W represents the --CH.sub.2, >CO or >CH--OR.sup.6 group (in which R.sup.6 represents any one of the atoms or groups defined for R.sup.3 and may be the same as or different from R.sup.3); andY and Z are the same or different and each represents an oxygen atom or an imino (.dbd.NH) group;or a pharmaceutically acceptable salt thereof.