Patent ID: 6331623
Filing Date: 2001-12-18
Classification: A61P,C07D

Abstract:
A pyrrolesulfonamide compound or a salt thereof, said pyrrolesulfonamide compound being represented by the following formula (I): ##STR55##whereinthe ring P represented by ##STR56##means a pyrrole ring represented by the following structure: ##STR57##in which A represents a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group or a substituted or unsubstituted alkynylene group; Y represents a group ##STR58##in which W represents CH, C.dbd. or a nitrogen atom; and, when W represents CH, m stands for 0 or 1, B represents a carbonyl group, a sulfonyl group, an alkylene group, an alkenylene group, a group --C(OH)R.sub.1 -- in which R.sub.1 represents a substituted or unsubstituted aryl group, a group --CHR.sub.2 -- in which R.sub.2 represents a substituted or unsubstituted aryl group, or a substituted or unsubstituted cyclic or acyclic acetal group; when W represents C.dbd., m stands for 1, B represents a group ##STR59##in which the double bond is coupled with W and R.sub.3 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; when W represents a nitrogen atom, m stands for 0 or 1, and B represents a carbonyl group, a sulfonyl group, an alkylene group, an alkenylene group or a group --CHR.sub.4 -- in which R.sub.4 represents a substituted or unsubstituted aryl group; E.sub.1 and E.sub.2 each independently represents a hydrogen atom or a lower alkyl group; and D represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group;l represents 0 or 1;the dashed line indicates the presence or absence of a bond; and, when the bond indicated by the dashed line is present, Z.sub.2 is not present and Z.sub.1, represents a hydrogen atom but, when the bond indicated by the dashed line is absent, Z.sub.1 represents a hydrogen atom and Z.sub.2 represents a hydroxyl group; or Z.sub.1 and Z.sub.2 are combined together to represent an oxygen atom or a group NOR.sub.5 in which R.sub.5 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted aryl group; andR represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl-alkyl group or a substituted or unsubstituted aralkyl group.