Patent ID: 8415501
Filing Date: 2013-04-09
Classification: A61P,C07C

Abstract:
1. A method of preparing a crystalline polymorph of N-[1-(R)-(−)-(1-naphthyl)ethyl]-3-[-3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride having a powder X ray powder diffraction (XRPD) pattern having peaks at diffraction angle 2 θ of 16.6942; 17.6152; 19.4992; 20.2946; and 20.5877, said method comprising: a. melting cinacalcet polymorph Form I at 190° C. and quenching said amorphous form in a cooling bath of dry ice and acetone for 30 minutes; b. grinding said quenched amorphous form to reduce particle size of said quenched amorphous form, and c. heating the amorphous quenched, size-reduced particles from step (b) at 90° C. for approximately 3.5 hours.