Patent ID: 6017908
Filing Date: 2000-01-25
Classification: A61K,A61P,C07C

Abstract:
An isolated 3-epi vitamin D.sub.2 compound having the formula (I) ##STR9## wherein: the orientation of the X and R.sub.1 groups on the A-ring is in an .alpha.-configuration; A.sub.1, A.sub.2 and A.sub.3 are each independently selected from the group consisting of a single and a double bond; X is selected from the group consisting of a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, and an aryl group; R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are each independently selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, and an aryl group; and wherein R.sub.4 is a saturated or unsaturated carbon chain represented by the general formula: ##STR10## wherein I represents the above-described general formula; A.sub.4 and A.sub.5 are a single, or a double bond; R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are each independently selected from the group consisting of a hydrogen, a deuterium, a hydroxy, an alkyl, an alkoxide, an O-acyl, a halogen, a haloalkyl, a hydroxyalkyl, an oxygen atom, an amine and a thiol group; R.sub.11 and R.sub.12 are each selected from the group consisting of an alkyl, a hydroxyalkyl, a halogen, a hydroxy, a haloalkyl and a deuteroalkyl; and Z is selected from the group consisting of a hydrogen, a hydroxyl, and O-acyl moiety; wherein n is an integer having a value from 1 to 5.