Patent ID: 6281358
Filing Date: 2001-08-28
Classification: C07D

Abstract:
A process for the preparation of substituted pyrimidines of formula I, ##STR8##whereinR.sup.1 and R.sup.2 each independently represent an optionally substituted alkyl, cycloalkyl, phenyl or heteroaryl group,R.sup.3 and R.sup.4 each independently represent a hydrogen atom or an optionally substituted alkyl or phenyl group, and X represents O or S, which comprises reacting an amidine of formula II, ##STR9##or a salt thereof, wherein R.sup.1 has the meaning given for formula I, with a 3,3-disubstituted vinylcarbonyl compound of formula III ##STR10##wherein R.sup.3 and R.sup.4 have the meaning given, and L represent a halogen atom or a group of formula --X--R.sup.2,(a) in an inert solvent, in the presence of a base and a compound of formula IVH--X--R.sup.2 (IV)wherein X and R.sup.2 have the meaning given, in the event that L represent a halogen atom, or(b) in an inert solvent and in the presence of a base, in the event that L represents a group of formula --X--R.sup.2.