Patent ID: 7759379
Filing Date: 2010-07-20
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): in which: p represents the integer 0; A represents aryl, heteroaryl or a monocyclic or bicyclic fused carbocyclic or heterocyclic 5- to 11-membered radical, all these radicals optionally being substituted with one or more substituents, which may be identical or different, chosen from the values of R3; X represents a single bond or the following divalent radicals: —N(R6)-; —NH-alk-; alkylene; —O—; —C(O)—; —S(O)n-; —N(R6)-C(O)—; NH—CO-alk-, —N(R6)-C(O)—N(R6′)—; —N(R6)-C(S)—N(R6′)—; —N(R6)-C(O)O—; —N(R6)-SO2—; —N(R6)-SO2—N(R6′)—; —C(O)—N(R6)-; —SO2—N(R6)-; and —C(O)O—; L the radical NR1R2 is such that: either R1 and R2, which may be identical or different, are such that: R1 represents a hydrogen atom; alkyl, alkenyl, alkynyl and cycloalkyl, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; aryl, heteroaryl, arylalkyl and heteroarylalkyl in which each of the aromatic rings may optionally be substituted with one or more substituents, which may be identical or different, chosen from the values of R8; —SO2R9; —C(O)R9; —C(O)OR9; —C(O)NR10R11, —C(S)NR10R11 and —SO2NR10R11; and R2 represents a hydrogen atom; alkyl, alkenyl, alkynyl and cycloalkyl, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or R1 and R2 form, together with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more other hetero atoms, which may be identical or different, chosen from O, N, NR12 and S, and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or NR1 with L R3 represents a hydrogen atom; a halogen atom; hydroxyl; alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy and alkylenedioxy, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or R3 represents —NR13R14; —C(O)R13; —S(O) provided that when A represents a mono or bicyclic fused 11-membered radical, R3 represents one or more oxo; R4, R4′, R R4 represents a hydrogen atom; a halogen atom; an alkyl, alkenyl, alkynyl or cycloalkyl radical, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or R4 represents aryl and heteroaryl, these last two radicals optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R8; or R4 represents oxo; L Y represents a saturated, partially saturated or unsaturated N-heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R5; R5 represents a hydrogen atom; a halogen atom; an alkyl, alkenyl, alkynyl or cycloalkyl radical, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or R5 represents aryl, arylalkyl, heteroaryl and heteroarylalkyl, in which the aromatic rings are optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R8; or R5 represents —OR18; —NR19R20; —NR19COR20; —NR19CONR19′R20; —NR19—S(O)2—R20; —NR19-S(O)2—NR19′R20; —COR18; COOR21; —CONR22R23; —S(O)nR18; —SO2NR22R23; cyano; or nitro; R6 is such that: either R6 represents a hydrogen atom; an alkyl, alkenyl, alkynyl, acyl or cycloalkyl radical, all optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R6 represents aryl and heteroaryl, these last two radicals optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R8; or R6 with NR1R2 together form a 4- to 8-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; or R6 with L R6′, which may be identical to or different from R6, is chosen from the values of R6; R7 represents a halogen atom; alkyl; cycloalkyl; cycloalkylalkyl; hydroxyl; alkoxy; cycloalkoxy; cyano; —CF3; —NR24R25; —NR26COR27; —NR26CONR26′R27; —NR26—S(O)2—R27; —NR26—S(O)2—NR26′R27; —COOR26; —COR26; —CO(NR24R25); S(O)nR26; —S(O)2NR24R25; 4- to 7-membered heterocycle optionally substituted with one or more substituents, which may be identical or different, chosen from OH and NH2 radicals, halogen atoms, and alkyl, alkoxy or oxo radicals; or R7 represents aryl optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and alkyl and alkoxy radicals; or R7 represents heteroaryl, optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and NH2, alkyl and alkoxy radicals; or R7 represents phenoxy, optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and alkyl and alkoxy radicals; R8, which may be identical to or different from R7, represents the same values as R7; nitro; —OCF3; alkylenedioxy; difluoromethylenedioxy; or benzyl optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and alkyl and alkoxy radicals; R9, which may be identical to or different from R6, represents the same values as R6; R10 and R11, which may be identical to or different from each other and also which may be identical to or different from R6, are chosen from the same values as R6 and may optionally form, with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R12 represents a hydrogen atom; an alkyl, alkenyl, alkynyl, cycloalkyl, alkylCO or alkylSO R13, which may be identical to or different from R6, represents the same values as R6; R14, which may be identical to or different from R13, represents the same values as R13 and also represents C(O)R28; C(O)N28R29; SO2R28 and SO2NR28R29; R13 and R14 may optionally form, together with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R15 and R16, which may be identical to or different from each other and also which may be identical to or different from R13, are chosen from the same values as R13 and may optionally form, with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R17 represents a hydrogen atom, alkyl or cycloalkyl; R18, which may be identical to or different from R6, represents the same values as R6; R19 and R20, which may be identical to or different from each other and also which may be identical to or different from R6, are chosen from the same values as R6 and may optionally form, with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R21, which may be identical to or different from R13, represents the same values as R13 or hydrogen; R22 and R23, which may be identical to or different from each other and also which may be identical to or different from R6, are chosen from the same values as R6 and may optionally form, with the nitrogen atom to which they are attached, a 4- to 10-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N and NR12 and optionally substituted with one or more substituents, which may be identical or different, chosen from the values of R7; R24 and R25, which may be identical or different, represent a hydrogen atom or an alkyl, alkenyl or alkynyl radical optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and OH and alkoxy radicals, or alternatively R24 and R25 may optionally form, with the nitrogen atom to which they are attached, a 4- to 7-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N, N-alkyl and N—C(O)alkyl, and optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and OH, alkyl, alkoxy and oxo radicals; R26 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and OH and alkoxy radicals; R26′, which may be identical to or different from R26, represents the same values as R26; R27, which may be identical to or different from R26, represents the same values as R26; R26 and R27 may also optionally form, with the nitrogen atom to which they are attached, a 4- to 7-membered heterocycle optionally containing one or more hetero atoms, which may be identical or different, chosen from O, S, N, N-alkyl and N—C(O)alkyl, and optionally substituted with one or more substituents, which may be identical or different, chosen from halogen atoms and OH, alkyl, alkoxy and oxo radicals; R28, which may be identical to or different from R26, represents the same values as R26; R29, which may be identical to or different from R26, represents the same values as R26; R30, which may be identical to or different from R26, represents the same values as R26; and n represents the integers 0, 1 and 2; or a racemate, enantiomer, diastereoisomer of such compound or mixture thereof, or an addition salt of such compound, racemate, enantiomer, diastereomer or mixture with a mineral acid or organic acid or with a mineral base or organic base.