Patent ID: 6956033
Filing Date: 2005-10-18
Classification: A61K,A61P,C07D

Abstract:
1. A 3,4-dihydroisoquinoline derivative compound of formula (I) (wherein R 1) hydrogen, or 2) C1˜8 alkyl or R Z is 1) —CR 2) —O—, R 1) hydrogen, 2) C1˜8 alkyl, 3) C1˜8 alkoxy or 4) hydroxy, or R R 1) hydrogen or 2) C1˜8 alkyl, or R Cyc1 represented by R 1) C3˜10 cycloalkyl or 2) 3˜10 membered mono-cyclic heteroring comprising 1˜2 of heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, Cyc1 may be substituted with R R 1) C1˜8 alkyl, 2) C1˜8 alkoxy, 3) hydroxy, 4) —COOR R R R 1) hydrogen, 2) C1˜8 alkyl, 3) C1˜8 alkoxy, 4) hydroxy, 5) cyano, 6) halogen, 7) —COOR 8) —CONR 9) Cyc2, 10) C2˜8 alkenyl, 11) C2˜8 alkynyl, 12) —NR 13) nitro, 14) formyl, 15) C2˜8 acyl, 16) hydroxy, C1˜8 alkoxy, Cyc2, —NR 17) —NR 18) —NR 19) —SO 20) C2˜8 alkenyl substituted with —COOR 21) —CH═N—OH, 22) —(C1˜8 alkylene)—NR 23) C1˜8 alkylthio; R R R R R R R R (abbreviated as ring hereafter) is Cyc2, but the atom which attaches to the carbonyl group in formula (I) is carbon; Cyc2, represented by R 1) C3˜15 mono-, bi- or tri-cyclic (fused or spiro) carbocyclic ring or 2) 3˜15 membered mono-, bi- or tri-cyclic (fused or spiro) heterocyclic ring comprising 1˜4 of hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur, Cyc2 may be substituted with 1˜5 of R R 1) C1˜8 alkyl, 2) C2˜8 alkenyl, 3) C2˜8 alkynyl, 4) C1˜8 alkoxy, 5) C1˜8 alkylthio, 6) hydroxy, 7) halogen, 8) nitro, 9) keto, 10) carboxy, 11) formyl, 12) cyano, 13) —NR R R R R R 1) C1˜8 alkyl, 2) C2˜8 alkenyl, 3) C1˜8 alkyl substituted with 1˜5 of R R R R Cyc3 is 1) C3˜15 mono-, bi- or tri-cyclic (fused or spiro) carbocycle, or 2) 3˜15 membered mono-, bi- or tri-cyclic (fused or spiro) heteroring comprising 1˜4 of heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, Cyc3 may be substituted with 1˜5 of R R 1) C1˜8 alkyl, 2) C2˜8 alkenyl, 3) C2˜8 alkynyl, 4) C1˜8 alkoxy, 5) C1˜8 alkylthio, 6) hydroxy, 7) halogen, 8) nitro, 9) keto, 10) cyano, 11) benzyl, 12) benzyloxy, 13) C1˜8 alkyl, C1˜8 alkoxy or C1˜8 alkylthio substituted with 1˜5 of R R R R R R Cyc4 is 1) C5˜7 mono-cyclic carbocyclic ring, or 2) 5˜7 membered mono-cyclic heterocyclic ring comprising 1-2 of heteroatom selected from the group consisting of oxygen, nitrogen and sulfur; (abbreviated as broken line a hereafter) and (abbreviated as broken line b hereafter) is 1) a bond or 2) a double bond; R with the proviso that, 1) when the broken line a is a bond, then the broken line b is a double bond and R 2) when the broken line a is a double bond, then the broken line b is a bond and R 3) 2-(3,3-dimethyl-3,4-dihydro-(2H)-isoquinolin-1-ylidene)-1-phenylethan-1-one is excluded), or a non-toxic salt thereof.