Patent ID: 6403593
Filing Date: 2002-06-11
Classification: C07D

Abstract:
A triazole compound of formula I whereinA is a straight-chain or branched C1-C18-alkylene group, or a straight chain or branched group consisting of 1 to 18 methylene members and one or two members selected from the group consisting of O, S, NR3, NR3CO, COO, OCO, C3-C6-cycloalkylene, a double bond and a triple bond, X is R1 is H, CO2R3, NR3R4, OR4, C3-C6-cycloalkyl or C1-C8-alkyl which is unsubstituted or substituted by OH, OC1-C8-alkyl or halogen; R2 has the meanings indicated for R1 or is CF3, SR3, halogen or CN; R3 is H or C1-C8-alkyl which is unsubstituted or substituted by OH, OC1-C8-alkyl, phenyl or halogen; R4 has the meanings indicated for R3 or is COR3 or CO2R3; Ar is an optionally fused phenyl ring selected from the group consisting of phenyl, naphthalene, dihydronaphthalene, tetrahydronaphthalene, quinoline, dihydroquinoline, tetrahydroquinoline, indole, dihydroindole, benzimidazole, benzothiazole, benzothiadiazole, benzopyrrole and benzotriazole, and which optionally fused phenyl ring is unsubstituted or carries from one to four substituents selected from the group consisting of: OR4, C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, CN, CO2R3, NO2, SO2R3, SO3R3, NR3R4, SO2NR3R4, SR3, CF3, CHF2, C3-C6-cycloalkyl, phenyl, naphthalene, pyrrolidine, piperidine, morpholine, piperazine, pyridine, pyrimidine, triazine, pyrrole, thiophene, thiazole, imidazole, oxazole, isoxazole, pyrazole and thiadiazole, wherein each of the cyclic substituents is unsubstituted or substituted by C1-C8-alkyl, halogen, OC1-C8-alkyl, OH, NO2 or CF3, or a salt thereof with a physiologically tolerated acid.