Patent ID: 9051335
Filing Date: 2015-06-09
Classification: A61K,A61P,C07D

Abstract:
1. A method for reducing pruritus caused by multiple sclerosis, said method comprising the steps of: identifying a patient having pruritus caused by multiple sclerosis; and administering an effective amount of a compound represented by Formula (I) to said patient wherein R R R A represents —XC(═Y)—, —XC(═Y)Z—, —X— or —XSO B represents valence bond, C R wherein Q represents NH, O, or S; T represents CH 2 , NH, S, or O; 1 represents an integer of 0 to 5; and m and n independently represent integers of 0 to 5, the total of m and n being not more than 5; each of said organic groups may have at least one substituent selected from the group consisting of C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 1 -C 5 alkanoyloxy, hydroxy, fluorine, chlorine, bromine, iodine, amino, nitro, cyano, isothiocyanato, trifluoromethyl, trifluoromethoxy and methylenedioxy; R R R the Formula (I) includes (+), (−) and (±) isomers or a pharmaceutically acceptable acid addition salt thereof.