Patent ID: 6121244
Filing Date: 2000-09-19
Classification: A61K

Abstract:
A method of inhibiting the growth of tumor cells sensitive to at least one compound represented by formula (I): ##STR4## wherein R' is a hydrogen atom or a methyl group;R.sub.1 is an aminoaceyl radical --CO(CH.sub.2).sub.m NR.sub.3 R.sub.4, wherein m=1, 2 or 3, R.sub.3 and R.sub.4, which can be the same or different, are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group or form with the nitrogen atom to which they are bound, a five- or six-membered heterocyclic ring optionally containing another hetero atom selected from the group consisting of O, S and N, wherein said N may be substituted by a methyl or 2-hydroxyethyl group;R.sub.2 is a hydroxy, C.sub.1 -C.sub.6 alkoxy, NR.sub.3 R.sub.4 amino or --NH--(CH.sub.2).sub.m --NR.sub.3 R.sub.4 aminoalkylamino group, wherein m, R.sub.3 and R.sub.4 are as defined above, or a substituted --NH--(CH.sub.2).sub.m --R.sub.5 alkylamino group, wherein m is as defined above, and R.sub.5 is a five- or six-membered heterocyclic ring, wherein the heteroatom is nitrogen which may be substituted with a methyl or ethyl group;X is the anion of a pharmaceutically acceptable organic or inorganic acid; and n is 0, 1 or 2;comprising administering to a mammal in need thereof a synergistic effective amount of said compound represented by formula (I) in combination with an effective amount at least another antineoplastic agent.