Patent ID: 6218405
Filing Date: 2001-04-17
Classification: A61P,C07D

Abstract:
Compounds of formula I ##STR28##including enantiomers and pharmaceutically acceptable salts thereof in whichA is methylene or --O--;B is methylene or --O--;G.sub.1 --G.sub.2 --G.sub.3 represent --N(R')--C(R').dbd.N--, --N.dbd.C(R"")--N(R')--, --N(R')--C(R"").dbd.C(R'"")--, --C(R'"").dbd.C(R"")--N(R')--, --N(R')--N.dbd.C(R"")--, --C(R"").dbd.N--N(R')--, --N(R')--N.dbd.N--, --N.dbd.N--N(R')--, --N.dbd.C(R"")--O--, --N.dbd.C(R"")--S--, --O--C(R"").dbd.N--, --S--C(R"").dbd.N--, --O--N.dbd.C(R"")--, --S--N.dbd.C(R"")--, --C(R"").dbd.N--O--, --C(R"").dbd.N--S--, --S--C(R"").dbd.C(R'"")--, --C(R"").dbd.C(R'"")--S--, --O--C(R"").dbd.C(R'"")--, --C(R"").dbd.C(R'"")--O-- or --O--C(R')(R')--O--;R' is H or an alkyl group containing 1 to 3 carbon atoms;R"" and R'"", which are the same or different, are H; halo; an alkyl group containing 1 to 3 carbon atoms optionally substituted by one or more halo; carboxy; an alkanoyl group containing 1 to 6 carbon atoms; an alkoxycarbonyl group in which the alkoxy group contains 1 to 3 carbon atoms; formyl; cyano; or a carbamoyl group or carbamoylmethyl group each optionally N-substituted by one or two alkyl groups, which may be the same or different, each containing 1 to 3 carbon atoms;g is 0, 1 or 2;R.sub.1 represents an alkyl group containing 1 to 3 carbon atoms optionally substituted by one or more halo; an alkoxy group containing 1 to 3 carbon atoms optionally substituted by one or more halo; halo; or an alkylthio group containing 1 to 3 carbon atoms optionally substituted by one or more halo; the substituents represented by R.sub.1 being the same or different when g is 2;R.sub.2 is H or an alkyl group containing 1 to 3 carbon atoms;R.sub.3 and R.sub.4, which are the same or different, are H, or an alkyl group containing 1 to 3 carbon atoms;U is an alkylene chain containing 1 to 3 carbon atoms, optionally substituted by one or more alkyl groups each containing 1 to 3 carbon atoms;Q represents a divalent group of formula IIa, IIb or IIc ##STR29##in which V is (CH.sub.2).sub.n, wherein n is 0, 1, 2 or 3, optionally substituted by one or more alkyl groups each containing 1 to 3 carbon atoms;V' is an alkylene chain containing 2 to 6 carbon atoms, optionally substituted by one or more alkyl groups each containing 1 to 3 carbon atoms;E is an alkylene chain containing 0 to 2 carbon atoms and E' is an alkylene chain containing 1 to 4 carbon atoms provided that the total number of carbon atoms in E and E' amounts to 3 or 4;R.sub.5 and R.sub.6, which may be the same or different, are H or an alkyl group containing 1 to 4 carbon atoms; andT represents phenyl, 1- or 2-naphthyl, 1-naphth[2,1-d][1,2,3]oxadiazolyl, 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, 2- or 3-thienyl, 2- or 3-furyl, 2-, 3- or 7-benzo[b]furanyl, 2,3-dihydro-7-benzo[b]furanyl, 2-, 3- or 7-benzo[b]thiophenyl, 3-, 4- or 5-pyrazolyl, 1,2,3-triazol-4-yl, 1,2,3-triazol-5-yl, 1,2,4-triazol-2-yl, 5-tetrazolyl, 2-, 3- or 4-quinolinyl, 2- or 4-quinazolinyl, 3-, 4- or 5-isoxazolyl, 2-, 4- or 5-oxazolyl, 3-, 4- or 5-isothiazolyl or 2-, 4- or 5-thiazolyl each of which may be optionally substituted by one or more substituents selected from a) halo, b) an alkyl group containing 1 to 4 carbon atoms optionally substituted by one or more halo, c) an alkoxy group containing 1 to 3 carbon atoms optionally substituted by one or more halo, d) an alkylthio group containing 1 to 3 carbon atoms optionally substituted by one or more halo, e) hydroxy, f) an acyloxy group containing 1 to 3 carbon atoms, g) hydroxymethyl, h) cyano, i) an alkanoyl group containing 1 to 6 carbon atoms, j) an alkoxycarbonyl group containing 2 to 6 carbon atoms, k) a carbamoyl group or carbamoylmethyl group each optionally N-substituted by one or two alkyl groups each containing 1 to 3 carbon atoms, I) a sulphamoyl or sulphamoylmethyl group each optionally N-substituted by one or two alkyl groups each containing 1 to 3 carbon atoms, m) an amino group optionally substituted by one or two alkyl groups each containing 1 to 5 carbon atoms, n) 1-pyrrolidinyl or 1-piperidinyl, o) nitro or p) acetamido.