Patent ID: 6201007
Filing Date: 2001-03-13
Classification: A61P,C07D,Y02P

Abstract:
A compound of the following formula: ##STR34##and the salts thereof, whereinA is hydrogen, halo, hydroxy, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo C.sub.1 -C.sub.6 alkoxy, oxo, OY wherein Y is a hydroxy protecting group, or absent;the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent;Ar.sup.1 is phenyl optionally substituted by one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy, CF.sub.3, carboxy-C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alkoxy-carbonyl-C.sub.1 -C.sub.4 alkoxy;Ar.sup.2 is aryl or heteroaryl selected from phenyl, napththyl, thienyl, furyl, and pyrrolyl, the aryl or heteroaryl being optionally substituted by one or more substituents selected from halo, hydroxy, amino, nitro, carboxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylamino, di C.sub.1 -C.sub.4 alkylamino, halo C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkythio and sulfonyl methyl;R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or OY wherein Y is a hydroxy protecting group; andR.sup.2 and R.sup.3 are independently selected from hydrogen, hydroxy, C.sub.1 -C.sub.7 alkyl optionally substituted by one or more hydroxy or halo, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.7 alkoxy, phenyl optionally substituted by halo, phenyl C.sub.1 -C.sub.7 alkyl, halo substituted phenyl C.sub.1 -C.sub.7 alkyl, and (CH.sub.2) nX--R.sup.4 wherein n is one or two; X is O, NH or S and R.sup.4 is C.sub.1 -C.sub.3 alkyl, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a pyrrolidine, optionally substituted by C.sub.1 -C.sub.3 alkyl or halo.