Patent ID: 7572927
Filing Date: 2009-08-11
Classification: C07F

Abstract:
1. A method of producing an o-disubstituted aromatic compound, comprising: continuously conducting at least the following steps: (a) a step of mono-lithiating one halogen atom of an o-dihaloaromatic compound, using a first microreactor; (b) a step of making the thus-obtained monolithiated product to react with an electrophilic compound, using a second microreactor, to obtain a monosubstituted-monohaloaromatic compound; (c) a step of lithiating the other halogen atom of the o-dihaloaromatic compound, using a third microreactor; and (d) a step of making the thus-obtained lithiated product successively to react with an electrophilic compound, using a fourth microreactor, wherein a reaction temperature in a flow channel of each of the first microreactor and the second microreactor is in the range of from −85° C. to −60° C.