Patent ID: 8088734
Filing Date: 2012-01-03
Classification: A61K,A61P

Abstract:
1. An oral pharmaceutical composition comprising an active peptide agent that has an amide group at its C-terminus, and is not found in nature with an amide group at its C-terminus, wherein said active peptide agent is a human parathyroid hormone analog having the first 34 amino acids of human parathyroid hormone wherein the 34 th amino acid is amidated at its C-terminus, said composition further comprising an absorption enhancer effective to promote bioavailability of said active peptide agent, or a pharmaceutically acceptable pH-lowering agent that is present in said pharmaceutical composition in a quantity which, if said composition were added to ten milliliters of 0.1M aqueous sodium bicarbonate solution, would be sufficient to lower the pH of said solution to no higher than 5.5.