Patent ID: 7381795
Filing Date: 2008-06-03
Classification: A61P,C07K

Abstract:
1. A modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human; wherein the modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by amino acid residue substitutions at residue 57 and residue 67: where the substitution at residue 57 is selected from the group consisting of L57A, L57C, LS57D, L57E, L57G, L57H, L7K, L57N, L57P, L570, L570 , L75R, L57S, and L57T, and the substitution at residue 67 is selected from the group consisting of F67A, F67C, F67D, F67E, F67G, F67H, F67K, F67N, F67P, F67O, F67R, F67S, and F67T.