Patent ID: 6043217
Filing Date: 2000-03-28
Classification: A61K,A61P,C07K

Abstract:
An amide derivative of amythiamicin represented by the following general formula (I) ##STR16## wherein n is an integer of 1 to 6, R.sup.1 is a hydrogen atom, a carboxyl group or a hydroxylmethyl group, and R.sup.2 is a group of the formula --COOR.sup.3 where R.sup.3 is a hydrogen atom or a lower alkyl group or a benzyl group of which phenyl ring may optionally be substituted by a halogen or a hydroxyl group, or R.sup.2 is a group of the formula --NR.sup.4 R.sup.5 where R.sup.4 is a hydrogen atom or a lower alkyl group and R.sup.5 is a hydrogen atom, a lower alkyl group, 3-aminopropyl group, 3-[2-(p-chloro or bromophenyl)ethyl]aminopropyl group or 3-(n-butylamino)propyl group, or R.sup.2 is a methyl group, a hydroxyl group or a guanidino group of the formula --NH--C(.dbd.NH)--NH.sub.2, or a pharmaceutically acceptable salt or ester thereof.