Patent ID: 7572918
Filing Date: 2009-08-11
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of Formula (I): the process comprising: (a) reacting a compound of Formula (II); with a compound of Formula (III) or a salt thereof; and a first reductant to form a compound of Formula (IV) or a salt thereof; (b) reacting the compound of Formula (IV) or a salt thereof with an acid and water to form a compound of Formula (V) or a salt thereof; (c) reacting the compound of Formula (V) or a salt thereof with a compound of Formula (VI) or a salt or stereoisomer thereof; and a second reductant to form the compound of Formula (I) or a salt or stereoisomer thereof; wherein W, X, Y and Z are independently selected from the group consisting of CH, CR R each R each R each R each R each R R each R each R each R each R each R each R each R each R each —CH a is an integer from 2 to 7; b is 0 or 1; c is an integer from 2 to 7; provided that a+b+c equals 7, 8 or 9; m is an integer from 0 to 3; n is an integer from 0 to 3; p is 1 or 2; q is an integer from 0 to 4; r is an integer from 0 to 4; x is an integer from 2 to 4; and y is an integer from 2 to 4; wherein each heterocyclic group is independently selected from a pyrrolidine, imidazolidine, pyrazolidine, piperidine, 1,4-dioxane, morpholine, thiomorpholine, piperazine, and 3-pyrroline group; and wherein each heteroaryl group is independently selected from a pyrrole, imidazole, thiazole, oxazole, furan, thiophene, triazole, pyrazole, isoxazole, isothiazole, pyridine, pyrazine, pyridazine, pyrimidine, triazine, indole, benzofuran, benzothiophene, benzimidazole, benzthiazole, quinoline, isoquinoline, quinazoline, and quinoxaline group.