Patent ID: 7741446
Filing Date: 2010-06-22
Classification: A61K,A61P,C07K

Abstract:
1. An antibody composition comprising a fusion antibody that (i) is capable of crossing the blood-brain barrier (BBB) from the blood to the brain by binding to an endogenous BBB receptor-mediated transport system; (ii) comprises an Fc region that enables crossing the BBB from the brain to the blood by binding to an Fc receptor; and (iii) comprises a first and second antibody wherein the first antibody is an ScFv antibody that is covalently linked to either the carboxy terminus of the heavy chain of the second antibody or the carboxy terminus of the light chain of the second antibody, wherein the affinity of the ScFv for its antigen is more than 20% of the immunoglobulin from which the ScFv was derived.