Patent ID: 6951932
Filing Date: 2005-10-04
Classification: A61P,C07H

Abstract:
1. A method for synthesis of a 2-aralkyloxyadenosine or a 2-alkoxyadenosine, comprising: (a) activating a guanosine compound by halogenation of the aglycone to yield a halogenated compound; (b) hydrolyzing the halogenated compound by diazotization of the 2-amino moiety of the halogenated compound to yield a 2-hydroxy compound; (c) treating the 2-hydroxy compound with an alkylating agent to yield an alkylated compound; and (d) treating the alkylated compound with ammonia or an amine to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.