Patent ID: 8663688
Filing Date: 2014-03-04
Classification: A61K,A61P

Abstract:
1. A vaginal semisolid mucoadhesive formulation to treat estrogen deficit, the formulation comprising: a first bioadhesive gelling polymer that is a polyacrylic acid crosslinked with divinyl glycol in a quantity between 0.1% and 5% by weight of the vaginal semisolid mucoadhesive formulation; a second bioadhesive gelling polymer that is a polyacrylic acid crosslinked with allyl sucrose or allyl pentaerythritol in a quantity between 0.1% and 5% by weight of the vaginal semisolid mucoadhesive formulation; a neutralizing agent in sufficient quantity to position the vaginal semisolid mucoadhesive formulation's pH between 2 and 6; estriol in a quantity between 0.001% and 0.05% by weight of the vaginal semisolid mucoadhesive formulation, wherein the estriol is the only form of estrogen present in the vaginal semisolid mucoadhesive formulation; and water.