Patent ID: 8361777
Filing Date: 2013-01-29
Classification: A61P,C07C,C07K

Abstract:
1. A genetically engineered cell of the order of Actinomycetales, said cell being capable of producing a tetracycline compound, said tetracycline compound being produced by said cell by a genetically engineered biosynthetic pathway, wherein said genetically engineered biosynthetic pathway of said cell includes all polypeptides of SEQ ID NO: 1-5 and 8, wherein each of said polypeptides of SEQ ID NO: 1-5 and 8 can be substituted by a substituting polypeptide which is at least 95% identical to said substituted polypeptide, and wherein said substituting polypeptide has the same catalytic function as said substituted polypeptide.