Patent ID: 6562836
Filing Date: 2003-05-13
Classification: A61K,A61P,Y10S

Abstract:
A method for inhibiting IAPP-associated amyloid deposits in a subject, comprising administering to said subject an effective amount of an IAPP-inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that said IAPP-associated amyloid deposits are inhibited, wherein said IAPP-inhibiting compound is of the formula wherein A1, A2, A3, A4, A5 and A6 are independently alkyl, O, S, or â€”NH; n (for each individual A group) is 0 or 1; m is 1; l, p and q are independently 0, 1, or 2; R7, R8, R9, R10, R11, R12, R13, and R14 are independently hydrogen, an anionic group at physiological pH, alkyl, alicyclyl, heterocyclyl or aryl, and adjacent R groups may form an unsubstituted or substituted cyclic or heterocyclic ring.