Patent ID: 7829075
Filing Date: 2010-11-09
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method for expansion of hematopoietic cells and hematopoietic cell progenitors comprising culturing bone marrow or peripheral blood cells with a composition comprising an amount of zalpha11 Ligand comprising a sequence that is at least 90% identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO: 2, wherein the residue at position 44 is Asp, the residue at position 47 is Asp and the residue at position 135 is Glu, wherein the polypeptide binds a receptor as shown in SEQ ID NO: 115, sufficient to produce an increase in the number of natural killer (NK) cells, cytotoxic T cells, or B cells in the bone marrow or peripheral blood cells as compared to bone marrow or peripheral blood cells cultured in the absence of zalpha11 Ligand.