Patent ID: 7619003
Filing Date: 2009-11-17
Classification: B01J,C07B,C07C

Abstract:
1. A process for producing an optically active compound represented by the following formula (VI), the process comprising reacting water with a compound represented by the following formula (I) in the presence of one or more transition metal complexes having, as a ligand, an optically active compound represented by the following formula (III): wherein R 1 , R 2 and R 3 , which are different from each other, represent a hydrogen atom, a straight-chain, branched-chain or cyclic alkyl group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, a straight-chain or branched-chain alkoxy group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, an aralkyl group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, an aryl group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, an aralkyloxy group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, an alkylthio group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, or an aralkylthio group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine; any two of R 1 , R 2 and R 3 optionally form a ring; and R 4 , R 5 and R 6 each independently represent a hydrogen atom, or a straight-chain, branched-chain or cyclic alkyl group optionally substituted with alkyl, alkoxy, halogen, trifluoromethyl, phenyl, benzyl, hydroxyl, alkoxycarbonyloxy, benzoyl, benzyloxy, methoxymethyl, 2H-tetrahydropyran-2-yloxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, benzyloxycarbonyloxy, oxirane-2-yl, 1,3-dioxolan-4-yl, 2-oxo-1,3-dioxolan-yl, amino, dimethylamino, diethylamino, acetoxyamino, benzyloxycarbonylamine, aniline or benzylamine, R 4 and R 5 or R 5 and R 6 are optionally combined with each other together with an adjacent carbon atom having a double bond to form a ring; and A represents a carbonyl group or a single bond; wherein R 11 and R 12 each independently represent a hydrogen atom or a methyl group, R 13 , R 14 , R 15 and R 16 each independently represent a hydrogen atom or an alkyl group and, * represents an asymmetric carbon atom; wherein R 1 , R 2 and A have the same meanings as above, and * represents an asymmetric carbon atom.