Patent ID: 6620782
Filing Date: 2003-09-16
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formulae I or II or III: or a pharmaceutically acceptable salt or prodrug thereof, wherein:R1 is an optionally substituted alkyl or hydrogen; R3 is an N-protecting group; R2 is hydrogen or optionally substituted alkyl; Q is an optionally substituted saturated or partially saturated carbocycle or heterocycle; X is a peptide of 1-4 amino acids or a bond; Y is a peptide of 1-4 amino acids or a bond; A is CR6 or nitrogen; B is CR7 or nitrogen; C is CR8 or nitrogen; D is CR9 or nitrogen; provided that not more than two of A, B, C or D is nitrogen; and R6-R9 independently are hydrogen, halo, C1-C6 haloalkyl, C6-C10 aryl, C4-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C10 aryl(C1-C6)alkyl, C6-C10 aryl(C2-C6)alkenyl, C6-C10 aryl(C2-C6)alkynyl, C1-C6 hydroxyalkyl, nitro, amino, cyano, C1-C6 acylamino, hydroxy, C1-C6 acyloxy, C1-C6 alkoxy, alkylthio, or carboxy; or one of R6 and R7, or R7 and R8, or R8 and R9 are taken together with the carbon atoms to which they are attached to form a carbocycle or heterocycle; E is C14, nitrogen, oxygen or sulfur; F is C15, nitrogen, oxygen or sulfur; G is C16, nitrogen, oxygen or sulfur; provided that only one of E, F, G is nitrogen, oxygen or sulfur and R14-R16 are independently hydrogen, halo, C1-C6 haloalkyl, C6-C10 aryl, C4-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C10 aryl(C1-C6)alkyl, C6-C10 aryl(C2-C6)alkenyl, C6-C10 aryl(C2-C6)alkynyl, C1-C6 hydroxyalkyl, nitro, amino, cyano, C1-C6 acylamino, hydroxy, C1-C6 acyloxy, C1-C6 alkoxy, alkylthio, or carboxy; or one of R14 and R15, or R15 and R16, are taken together with the carbon atoms to which they are attached to form a carbocycle or heterocycle.