Patent ID: 6127578
Filing Date: 2000-10-03
Classification: A61K,C07C,Y10S

Abstract:
A fumonisin derivative in the form of a racemic mixture or a single isomer having the formula: ##STR2## wherein the Spacer Group is selected from the group consisting of straight chain or branched C.sub.1 -C.sub.20 alkyl, straight chain or branched C.sub.1 -C.sub.20 hydroxyalkyl and straight chain or branched C.sub.1 -C.sub.20 dihydroxyalkyl; Z is selected from the group consisting of H, O, NH, NQ, NQC(O), NHC(O), CO.sub.2, C(O)NH, and C(O)NQ, wherein Q is straight chain or branched C.sub.1 -C.sub.6 alkyl; W is selected from the group consisting of no substituent, H, straight chain or branched C.sub.1 -C.sub.6 alkyl, aryl, phenyl substituted by straight chain or branched C.sub.1 -C.sub.6 alkyl or halo, C(O)(CH.sub.2).sub.n CO.sub.2 H (where n=1-6), C(O)(CH.sub.2).sub.n CW'.sub.2 CO.sub.2 H, where W' is selected independently from H, straight chain or branched C.sub.1 -C.sub.6 alkyl, aryl, phenyl substituted by straight chain or branched C.sub.1 -C.sub.6 alkyl or halo, and (CH.sub.2).sub.n CO.sub.2 H, wherein n=1-6; X is selected from the group consisting of H, methyl, CH.sub.2 NQ'.sub.2 (where Q' is selected independently from H, straight chain or branched C.sub.1 -C.sub.20 alkyl, and acyl, wherein acyl is defined as C(O)Q"" where Q"" is straight chain or branched C.sub.1 -C.sub.20 alkyl); V is OH, and Y is H; but not fumonisin B.sub.1, fumonisin B.sub.2, fumonisin B.sub.3, fumonisin B.sub.4 or AAL toxin.