Patent ID: 7638319
Filing Date: 2009-12-29
Classification: C12Q,G16B

Abstract:
1. A method for detecting, in a sample from a subject infected with or suspected of being infected with HIV-1, the presence of HIV-1 virus that is selective for X4-co- receptors (X4 virus), the method comprising: (i) from the amino acid sequence of at least a pan of the HIV-1 gp120 V3 region peptide that includes positions 11, 24 and 25, or (ii) from the nucleotide sequence of at least a part of the HIV gp120 V3 coding region comprising codons encoding the amino acids at positions 11, 24, and 25, identifying the amino acids at positions 11, 24 and 25, or the codons encoding said amino acids, wherein the finding of a positively charged amino acid, or a codon encoding a positively charged amino acid, at any one of said positions upon examination of all three positions predicts the presence of the X4 virus in the subject.