Patent ID: 6613903
Filing Date: 2003-09-02
Classification: A61K,C07D

Abstract:
A compound of Formula 1 whereinX is â€”C(O)â€” or S(O)2â€”; R1 and R2 are independently hydrogen or a functional group that can be converted to hydrogen in vivo; R3 is C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl, aryl-R10-, aryl-N(R35)-, aryl-R11-N(R36)-, N(R37)(R38)-R39-, C1-C6alkyloxy or aryl-R13â€”O- wherein aryl is phenyl, biphenyl, indenyl, naphthyl, imidazolyl, 1,2,3-triazolyl, thiophenyl, pyridyl, quinolyl, isoquinolyl, benzofuranyl, indolyl or benzimidazolyl, wherein the aryl group is optionally substituted with halogen, nitro, cyano, hydroxy, trihalomethyl, C1-C6alkyl, R42â€”, R42â€”R14â€”, C1-C6alkyloxy, R42â€”Oâ€”, R42â€”S(O)2â€”, R42â€”R50, R42â€”N(R16)â€”, R18â€”C(O)â€”N(R19), R40â€”C(O)â€”Oâ€”R41â€”Oâ€”C(O)â€”, R42â€”C(O)â€”N(R21)â€” or R42â€”R23â€”C(O)â€”N(R24)â€”; R4 is hydrogen, R27â€”Oâ€”C(O)â€”, aryl-R28â€”Oâ€”C(O)â€”, R29â€”C(O)â€”Oâ€”R30â€”Oâ€”C(O)â€” or aryl-R31â€”C(O)â€”Oâ€”R32â€”Oâ€”C(O)â€” wherein aryl is phenyl, naphthyl or thiophenyl, wherein the aryl group is optionally substituted with halogen, nitro, cyano, trihalomethyl, R43â€”, R43â€”R33â€”, C1-C6alkyloxy or R43â€”R34â€”Oâ€”; and wherein R10, R11, R13, R14, R15, R23, R28, R30, R31, R32, R33, R34, R39, and R41 independently are C1-C6alkylene, wherein R18, R27, R29, and R40 independently are C1-C6alkyl and wherein R16, R19, R21, R24, R35, R36, R37 and R38 independently are hydrogen or C1-C6alkyl, wherein R42 and R43 are independently phenyl, naphthyl or thiophenyl; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, or any tautomeric form.