Patent ID: 6914144
Filing Date: 2005-07-05
Classification: A61P,C07D

Abstract:
1. A process for preparing the compound of structural formula I: comprising (a) producing a compound of structural formula II: by treating a 2,5-pyridine dicarboxylate diester of structural formula III: wherein R 1 and R 2 are each independently C 1-4 alkyl or phenyl-C 1-3 alkyl, with acetonitrile in a reaction solvent in the presence of a base; (b) producing a compound of structural formula IV: by reacting a compound of structural formula II: with an acylating, sulfonylating, or phosphorylating reagent; (c) producing the compound of structural formula VI: by hydrogenating a compound of structural formula IV: wherein Y is an acyl, sulfonyl, or phosphoryl group; and (d) hydrogenating the compound of structural formula VI: