Patent ID: 8791118
Filing Date: 2014-07-29
Classification: A61K,A61P,C07D

Abstract:
1. A pyridopyrazine selected from the group consisting of: 1-[3-(4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3,5-dimethyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-[3-(2,3,4-trimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-[3-(4-methyl-piperazin-1-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3H-benzoimidazol-5-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3-amino-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-(3-piperazin-1-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; hydrochloride; 1-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-p-tolyl-butyl)-urea; 1-[3-(3,4-dimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[4-(4-fluoro-phenyl)-butyl]-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-(4-methyl-4-phenyl-pentyl)-3-[3-(1-propyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-[3-(2,4-dimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(2-ethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3,5-dichloro-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-[3-(2H-pyrazol-3-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-[3-(4-hydroxy-2-methyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; Acetic acid 4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl ester; 1-[3-(1-ethyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3-bromo-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-(3-pyridin-3-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-urea; 1-[3-(2,3-dimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(1-butyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[4-(4-methoxy-phenyl)-butyl]-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-(4-phenyl-butyl)-3-[3-(piperidin-4-ylamino)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-(4-phenyl-butyl)-3-{3-[(pyridin-4-ylmethyl)-amino]-pyrido[2,3-b]pyrazin-6-yl}-urea; 1-[3-(4-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-(3-propylamino-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-(4-phenyl-butyl)-3-(3-o-tolyl-pyrido[2,3-b]pyrazin-6-yl)-urea; 3-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-benzoic acid ethyl ester; Ethyl-carbamic acid 4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl ester; 1-[3-(4-amino-3-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(2-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-[3-(2,3,4-trimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-(1-methyl-4-phenyl-butyl)-3-[3-(1-propyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-{3-[1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-[3-(2-ethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(3-chloro-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(2-amino-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-oxo-4-phenyl-butyl)-3-[3-(1-propyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; Carbonic acid ethyl ester 4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl ester; 1-[3-(2-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(4-hydroxy-cyclohexylamino)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 2,2-dimethyl-propionic acid 4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl ester; 1-[3-(4-methylsulfanyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3-cyano-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-[3-(3,4,5-trimethoxy-phenylamino)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-{3-[(S)-1-(3-chloro-phenyl)-2-hydroxy-ethylamino]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-[3-(3-hydroxy-4,5-dimethoxy-phenylamino)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-{3-[1-(3-chloro-phenyl)-2-hydroxy-ethylamino]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-[3-(4-fluoro-2-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-{3-[4-methoxy-3-(morpholine-4-sulfonyl)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-[3-(2-methoxy-pyridin-3-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(3-hydroxy-4-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-(3-furan-3-yl-pyrido[2,3-b]pyrazin-6-yl)-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-(3-pyridin-3-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(3-hydroxy-4-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(3-furan-3-yl-pyrido[2,3-b]pyrazin-6-yl)-3-(4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-[3-(4-methyl-piperazin-1-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-(3-piperidin-1-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(4-hydroxymethyl-2-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-(3-pyridin-4-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(3-hydroxymethyl-2-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-[3-(1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-[3-(4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(2-methoxy-pyridin-3-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-{3-[1-(3-hydroxy-propyl)-1H-pyrazol-4-yl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-{3-[1-(2,2-difluoro-ethyl)-1H-pyrrol-3-yl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-(1-methyl-4-phenyl-butyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; Phosphoric acid mono-(4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl)ester; 1-((R)-1-methyl-4-phenyl-butyl)-3-(3-morpholin-4-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(4-hydroxymethyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-{3-[1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-pyrido[2,3-b]pyrazin-6-yl}-urea; 1-(4-methyl-4-phenyl-pentyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-[3-(1-propyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-[3-(1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-(4-phenyl-butyl)-3-(3-pyrrolidin-1-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-(3-pyrrolidin-1-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(3-fluoro-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(3-hydroxymethyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-(3-morpholin-4-yl-pyrido[2,3-b]pyrazin-6-yl)-3-(4-phenyl-butyl)-urea; 1-[3-(3,5-dimethyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(3,4-dimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(2-methoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-((R)-1-methyl-4-phenyl-butyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-urea; 1-[3-(3-hydroxymethyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(4-hydroxymethyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-(2,4-dimethoxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-(4-phenyl-butyl)-3-(3-pyridin-4-yl-pyrido[2,3-b]pyrazin-6-yl)-urea; 1-[3-(3-fluoro-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(3-chloro-4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-(4-phenyl-butyl)-urea; 1-[3-((S)-3-methyl-morpholin-4-yl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-[3-(4-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-{3-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 2-methoxy-4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-benzoic acid; (S)-2-amino-3-(4-{6-[3-((R)-1-methyl-4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl)-propionic acid; hydrochloride; 3-{6-[3-((R)-1-methyl-4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-benzoic acid; (S)-2-amino-3-(4-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-phenyl)-propionic acid; 3-{6-[3-(4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-benzoic acid; 1-{3-[4-(2-methoxy-ethoxy)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; rac 1-{3-[4-(2-hydroxy-propoxy)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-(3-{4-[2-(2-hydroxy-ethoxy)-ethoxy]-phenyl}-pyrido[2,3-b]pyrazin-6-yl)-3-(4-phenyl-butyl)-urea; 1-{3-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-(4-phenyl-butyl)-urea; 1-[3-(3-methoxymethyl-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-{3-[3-(2-methoxy-ethoxymethyl)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-((R)-1-methyl-4-phenyl-butyl)-urea; 1-{3-[3-(2-dimethylamino-ethoxymethyl)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-3-((R)-1-methyl-4-phenyl-butyl)-urea; Methanesulfonic acid 3-{6-[3-((R)-1-methyl-4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3yl}-benzyl ester; 1-((R)-1-methyl-4-phenyl-butyl)-3-{3-[3-(2-morpholin-4yl-ethoxymethyl)phenyl]pyrido[2,3-b]pyrazin-6-yl}-urea; Ethyl-carbamic acid 3-{6-[3-((R)-1-methyl-4-phenyl-butyl)-ureido]-pyrido[2,3-b]pyrazin-3-yl}-benzyl ester; and 1-((R)-1-methyl-4-phenyl-butyl)-3-{3-[3-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-phenyl]-pyrido[2,3-b]pyrazin-6-yl}-urea; or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof.