Patent ID: 6555544
Filing Date: 2003-04-29
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition suitable as a depot formulation for administration by intramuscular or subcutaneous injection, comprising a dispersion of particles consisting essentially of a therapeutically effective amount of a crystalline 9-hydroxyrisperidone fatty acid ester having the formula or a salt, or a stereoisomer or a stereoisomeric mixture thereof, wherein R represents a straight C15 (pentadecyl) chain and the active ingredient is 9-hydroxyrisperidone palmitate ester; having a surfactant adsorbed to the surface thereof in an amount effective in maintaining a specific surface area >4 m2/g (corresponding to an effective average particle size of less than 2,000 nm) in a pharmaceutically acceptable carrier comprising water.