Patent ID: 7838562
Filing Date: 2010-11-23
Classification: A61K,A61P,Y02A

Abstract:
1. A method of treating a mammal in need of treatment for a vascular permeability disorder, comprising administering to the mammal in need of treatment for a vascular permeability disorder a therapeutically effective amount of a vascular endothelial sphingosine-1-phosphate receptor agonist, wherein the vascular endothelial sphingosine-1-phosphate receptor agonist is 2-amino-2-[2-(4-octaphenyl)ethyl]propane-1,3 diol, or 2-amino-2-methyl-4-[4-heptoxy-phenyl]butane-1-ol, wherein the vascular permeability disorder is increased vascular permeability associated with endothelial injury, thrombocytopenia, ischemic peripheral vascular disease, a peripheral vascular disorder associated with diabetes, Dengue hemorrhagic fever, acute respiratory distress syndrome, vascular leak syndrome, or a combination comprising one or more of the foregoing disorders.