Patent ID: 8501793
Filing Date: 2013-08-06
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound, which is selected from 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)thio]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3-[1-(3-methoxypropyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3[1-(2-cyclohexylethyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3[1-(3-methoxypropyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-1-nonenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-(4S)-4-{(1E,3S)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2{[2-((4S)-4{-(3S)-3[1-(4-fluorobutyl)cyclobutyl]-3-hydroxypropyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]thio}-1,3-thiazole-4-carboxylic acid, 2-{[2-(4S)-4-{(3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxypropyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]thio}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-3-(1-butylcyclobutyl)-3-hydroxy-1-propenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-7-methoxy-4,4-dimethyl-1-heptenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3[1-(2-phenylethyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E)-3-[1(2-ethoxyethyl)cyclobutyl]-3 -hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-4-methyl-4-phenyl-1-pentenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3-[1-(4-methyl-3-pentenyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-[1-(cyclohexylmethyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3-[1-(2-methoxyethyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3-[1-(4-methylpentyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-hydroxy-3-[1-(3-methyl-2-butenyl)cyclobutyl]-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3[1-(2-butynyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-3-(1-isopentylcyclobutyl)-1-propenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-[1-(3,3-dimethylbutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3[1-(5-fluoropentyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3[1-(cyclopropylmethyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-3-hydroxy-4-phenoxy-1-butenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-3-(1-butylcyclobutyl)-3-hydroxy-1-propenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-3-hydroxy-7-methoxy-4,4-dimethyl-1-heptenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-[1-(2-ethoxyethyl)cyclobutyl]-3-hydroxy-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-3-(1-benzylcyclobutyl)-3-hydroxy-1-propenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3-[1-(4-methoxybenzyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-({2-[(4S,5S)-4-((1E)-3-hydroxy-3-{1-[(2E)-2-pentenyl]cyclobutyl}-1-propenyl)-5-methyl-2-oxo-1,3-oxazolidin-3-yl]lethyl}sulfanyl)-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3[1-(3-methoxypropyl)cyclopentyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E,3R)-3-hydroxy-3[1-(3-methoxypropyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3-[1-(4-methyl-3-pentenyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3-[1-(2-pentynyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S,5S)-4-{(1E)-3-hydroxy-3-[1-(4,4,4-trifluorobutyl)cyclobutyl]-1-propenyl}-5-methyl-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E,4S)-4-(1-ethylcyclobutyl)-4-hydroxy-1-butenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E)-4-hydroxy-4-methyl-1-nonenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-4-[(1E)-5 -cyclohexyl-4-hydroxy-4-methyl-1-pentenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-2-oxo-4-[(1E)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[3-(1-hydroxycyclohexyl)-1-propenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4[4-hydroxy-7 -methoxy-4-methyl-1-heptenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-1-octenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-1-decenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-5-cyclohexyl-4-hydroxy-4-methyl-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-8-fluoro-4-hydroxy-4-methyl-1-octenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-5-methyl-2-oxo-4-[(1E)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-isopropyl-1-octenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-10-fluoro-4-hydroxy-4-methyl-1-decenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E,6E)-4-hydroxy-4-methyl-1,6-nonadienyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-6-phenyl-1-hexenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-5-cyclobutyl-4-hydroxy-4-methyl-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-5-cyclopropyl-4-hydroxy-4-methyl-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-4-methyl-1-octen-5-in-1-yl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-5-cyclopentyl-4-hydroxy-4-methyl-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E,5E,7E)-4-hydroxy-4-methyl-1,5,7-nonatrienyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-4-hydroxy-1-nonenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-6-cyclobutyl-4-hydroxy-4-methyl-1-hexenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[(1E)-5-cyclohexyl-4-hydroxy-1-pentenyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S,5S)-4-[3-(1-butylcyclobutyl)-3-hydroxypropyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-({2-[(4S,5S)-4-(3-hydroxy-4-phenoxybutyl)-5-methyl-2-oxo-1,3-oxazolidin-3-yl]ethyl}sulfanyl)-1,3-thiazole-4-carboxylic acid, 2-({2-[(4S,5S)-4-(8-fluoro-3-hydroxy-4,4-dimethyloctyl)-5-methyl-2-oxo-1,3-oxazolidin-3-yl]ethyl}sulfanyl)-1,3-thiazole-4-carboxylic acid, 2-({2-[(4S)-4-(4-hydroxy-4-methyloctyl)-2-oxo-1,3-oxazolidin-3-yl]lethyl}sulfanyl)-1,3-thiazole-4-carboxylic acid, 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfonyl}-1,3-thiazole-4-carboxylic acid, 2-[(2-{(4S)-2-oxo-4-[(1E,4R)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, and 2-[(2-{(4S)-2-oxo-4-[(1E,4S)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, a salt thereof, or an N-oxide thereof.