Patent ID: 8759012
Filing Date: 2014-06-24
Classification: A61P,C12Q

Abstract:
1. A method of increasing the dose of a statin to a human patient suffering from a cardiovascular disease comprising: Step (1) measuring SmgGDS expression level in leukocytes of the patient suffering from a cardiovascular disease with the use of an anti SmgGDS antibody before administration of a statin; Step (2) administering a statin to the patient; Step (3) measuring SmgGDS expression level in leukocytes of the patient with the use of an anti SmgGDS antibody after administration of the statin; Step (4) comparing the expression level measured in Step (1) to the expression level measured in Step (3) and detecting an SmgGDS expression level measured in Step (3) that is less than 1.4 times the SmgGDS expression level measured in Step (1); and Step (5) administering a statin dose to the patient that is increased by 10 mg as compared to the statin administered in Step (2).