Patent ID: 7972774
Filing Date: 2011-07-05
Classification: A61K,C07K,C12Q,G01N,Y10S

Abstract:
1. A method of detecting the presence of an oncogenic human Papillomavirus (HPV) E6 protein in a sample, said method comprising: contacting a sample suspected of containing an oncogenic HPV E6 protein with a PDZ domain polypeptide, wherein the PDZ domain polypeptide binds at least two oncogenic HPV E6 polypeptides and wherein the PDZ domain polypeptide is Atrophin-1 interacting protein PDZ domain 1, KIAA 1095 PDZ domain 1, INADL PDZ domain 8, KIAA 0807 PDZ domain 1, NeDLG PDZ domain 1, NeDLG PDZ domain 2, Sim. Rat outer membrane PDZ domain 1, PSD 95 PDZ domain 3 or TIP-1; and detecting any binding of said oncogenic HPV E6 protein in said sample to said PDZ domain polypeptide; wherein binding of said oncogenic HPV E6 protein to said PDZ domain polypeptide indicates the presence of an oncogenic HPV E6 protein in said sample.