Patent ID: 6310070
Filing Date: 2001-10-30
Classification: A61P,C07D

Abstract:
A purine derivative of the following formula (I), ##STR8##or a pharmaceutically acceptable salt thereof, whereinR.sup.1 isa hydrocarbon group having 17 or less carbon atoms ora substituted hydrocarbon group having 17 or less carbon atoms selected from the group consisting of(1) hydrocarbon group having 17 or less carbon atoms in which a carbon atom and two hydrogen atoms of one or more >CH.sub.2 g roups, --CH.sub.3 g roups, or .dbd.CH.sub.2 g roups which do not directly bind with the carbon atom at 2 position of the purine ring are replaced by carbonyl groups, sulfonyl groups, O, or S,(2) hydrocarbon group having 17 or less carbon atoms in which a carbon and one hydrogen atom of one or more >CH-- groups, >CH.sub.2 g roups, --CH.sub.3 g roups, .dbd.CH.sub.2 g roups, .dbd.CH-- groups, or .ident.CH which do not directly bind with the carbon atom at 2 position of the purine ring are replaced by N, C-halogen, or C--C.ident.N, or(3) hydrocarbon group having 17 or less carbon atoms in which(i) a carbon atom and two hydrogen atoms of one or more >CH.sub.2 g roups, --CH.sub.3 g roups, or .dbd.CH.sub.2 g roups which do not directly bind with the carbon atom at 2 position of the purine ring are replaced by carbonyl groups, sulfonyl groups, O, or S, and(ii) a carbon and one hydrogen atom of one or more >CH-- groups, >CH.sub.2 g roups, --CH.sub.3 groups, .dbd.CH.sub.2 g roups, .dbd.CH-- groups, or .ident.CH which do not directly bind with the carbon atom at 2 position of the purine ring are replaced by N, C-halogen, or C--C.ident.N; andR.sup.2 isa hydrocarbon group having 16 or less carbon atoms ora substituted hydrocarbon group having 16 or less carbon atoms selected from the group consisting of(1) hydrocarbon group having 16 or less carbon atoms in which carbon atom and two hydrogen atoms of one or more >CH.sub.2 g roups, --CH.sub.3 g roups, or .dbd.CH.sub.2 g roups which do not directly bind with the methylene group at 7 position of the purine ring are replaced by carbonyl groups, sulfonyl groups, O, or S,(2) hydrocarbon group having 16 or less carbon atoms in which a carbon and one hydrogen atom of one or more >CH-- groups, >CH.sub.2 g roups, --CH.sub.3 g roups, .dbd.CH.sub.2 g roups, .dbd.CH-- groups, or .ident.CH which do not directly bind with the methylene group at 7 position of the purine ring are replaced by N, C-halogen, or C--C.ident.N, or(3) hydrocarbon group having 16 or less carbon atoms in which(i) a carbon atom and two hydrogen atoms of one or more >CH.sub.2 g roups, --CH.sub.3 g roups, or .dbd.CH.sub.2 g roups which do not directly bind with the methylene group at 7 position of the purine ring are replaced by carbonyl groups, sulfonyl groups, O, or S, and(ii) a carbon and one hydrogen atom of one or more >CH-- groups, >CH.sub.2 g roups, --CH.sub.3 groups, .dbd.CH.sub.2 g roups, .dbd.CH-- groups, or .ident.CH which do not directly bind with the methylene group at 7 position of the purine ring are replaced by, N, C-halogen, or C--C.ident.N.