Patent ID: 7847088
Filing Date: 2010-12-07
Classification: C12Q

Abstract:
1. An oligonucleotide pair library comprising at least one oligonucleotide pair, said oligonucleotide pair comprising a first nucleic acid molecule and a second nucleic acid molecule wherein said oligonucleotide pair is selected from the group consisting of: (a) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:1 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:2; (b) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:3 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:4; (c) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:5 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:6; (d) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:7 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:8; (e) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:9 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:10; (f) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:11 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:12; (g) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:13 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:14; (h) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:15 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:16; (i) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:17 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:18; (j) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:19 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:20; (k) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:21 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:22; (l) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:23 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:24; (m) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:25 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:26; (n) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:27 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:28; (o) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:29 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:30; (p) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:31 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:32; (q) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:33 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:34; (r) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:35 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:36; (s) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:37 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:38; (t) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:39 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:40; (u) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:41 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:42; (v) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:43 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:44; (w) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:45 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:46; (x) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:47 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:48; (y) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:49 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:50; (z) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:51 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:52; (aa) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:53 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:54; (ab) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:55 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:56; (ac) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:57 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:58; (ad) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:59 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:60; (ae) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:61 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:62; (af) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:63 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:64; (ag) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:65 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:66; (ah) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:67 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:68; (ai) the oligonucleotide pair consisting of a first nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:69 and a second nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:70; (aj) an oligonucleotide pair comprising a first nucleic acid molecule having a nucleotide sequence that differs by one nucleotide alteration from that set forth in SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, or SEQ ID NO:69; and (ak) an oligonucleotide pair comprising a second nucleic acid molecule having a nucleotide sequence that differs by one nucleotide alteration from that set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, or SEQ ID NO:70.