Patent ID: 7049444
Filing Date: 2006-05-23
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula I or a pharmaceutically or veterinarily acceptable derivative thereof, wherein the “Ar” ring represents an optionally benzo-fused phenyl; R Y W is SO Y Het and if a S atom is present in a ring, it can be present as part of a —S—, S(O)— or —S(O R R or R R R E is H, CONR R R R R R R R R R R Z is a direct bond, CO or S(O) B is (CH R or R R or R R R R R R X is halogen, C m is 1 or 2; n is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and q is 0 or 1 wherein said process comprises: (a) for compounds of formula I in which q is 0 and R with a compound of formula III, wherein Z (b) for compounds of formula I in which q is 0 and R (c) for compounds of formula I in which q is 0 and R (d) where q is 0, reacting a compound of formula VIII, with a compound of formula IX wherein Lg is a leaving group; (e) for compounds of formula I in which q is 0 and R (f) for compounds of formula I in which q is 0 and R (g) for compounds of formula I in which q is 0 and R (h) for compounds of formula I in which q is 1, oxidizing a compound of formula I where q is 0; or (i) for compounds of formula I where q is 0, by reducing the corresponding compound of formula XXXI, where R and where desired or necessary converting the resulting compound of formula I into a pharmaceutically or veterinarily acceptable derivative.