Patent ID: 6117454
Filing Date: 2000-09-12
Classification: A61K,B82Y

Abstract:
A method of transmitting a pharmacologically active substance across the blood-brain barrier in a mammal to achieve a pharmacological effect in the central nervous system comprising the steps of:loading a nanoparticle with said pharmacologically active substance by absorption, adsorption, or incorporation thereto;coating said loaded nanoparticle with a surfactant selected from a group consisting of polyoxyethylene 20 sorbitan monolaurate, polyoxyethylene 20 sorbitan monopalmitate, polyoxyethylene 20 sorbitan monostearate, polyoxyethylene 20 sorbitan monooleate, and mixtures thereof;administering said coated nanoparticle to said mammal in a manner which allows said drug to enter the bloodstream whereby said pharmacologically active substance reaches and crosses the blood-brain barrier; andallowing said pharmacologically active substance to achieve said pharmacological effect.