Patent ID: 6432964
Filing Date: 2002-08-13
Classification: A01N,C07D

Abstract:
A method of combating fungi comprising applying to a locus infected or liable to be infected an effective fungicidal amount of a compound of general formula whereinR1 is hydrogen, hydroxy, acyl, acyloxy, optionally substituted amino, Ra, Ra3Si, RaS or RaO, where Ra is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; Z is oxygen or sulfur; M is a thiophene ring; and R3 and R4, which may be the same or different, have the same meaning as Ra or can be optionally substituted amino, hydrogen, halogen, cyano, nitro or a group ORc or S(O)mRc, where Rc has the same meaning as Ra or is hydrogen or acyl and m is 0, 1 or 2; or R3 and R4 together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; wherein any heterocyclic ring has 5, 6 or 7 ring members and up to 4 hetero atoms and is selected from the group consisting of furyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolindinyl, imidazolyl, dioxolanyl, oxazolyl, thiazolyl, imidazolyl, imidazolinyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyranyl, pyridyl, piperidinyl, dioxanyl, morpholino, dithianyl, thiomorpholino, pyridazinyl, pyriridinyl, pyrazinyl, piperzinyl, triazinyl, thiazolinyl, benzimidazolyl, tetrazolyl, benzoxazolyl, imidazopyridinyl, 1,3-benzoxazinyl, 1,3-benzothiazinyl, oxazolopyridinyl, benzofuranyl, quinolinyl, quinazolinyl, quinoxalinyl, sulfolanyl, dihydroquinazolinyl, benzothiazolyl, phthalimido, benzofuranyl, azepinyl, oxazepinyl, thiazepinyl, tetrahydrofuryl, diazepinyl and benzodiazepinyl; wherein any cycloalkyl, cycloalkenyl or cycloalkynyl group has 3 to 7 carbon atoms; any substituent when present on any alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or cycloalkynyl is halogen, cyano, optionally substituted alkoxy, optionally substituted alkylthio, mercapto, hydroxy, nitro, optionally substituted amino, acyl, acyloxy, acylthio, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted phenylthio, optionally substituted phenoxy, optionally substituted heterocycloloxy, optionally substituted heterocyclythio; any cycloalkyl, cycloalkenyl or cycloalkynyl is optionally substituted by optionally substituted by optionally substituted by alkyl, alkenyl or alkynyl and vice versa; substituents when present on any phenyl or heterocyclyl group may be the same or different and are Raâ€”(X)nâ€” where X is oxygen or sulfur and n is 0 or 1, optionally substituted amino, hydroxy, halogen, cyano, nitro, acyl, or two adjacent groups together with the carbon atoms to which they are attached form an optionally substituted benzo or heterocyclic ring and the heterocyclic group may be also be substituted by oxo or imino, substituents when present on an amino group are one or two R1 groups or two substituents form a 5 to 7 membered ring which optionally contains other hetero atoms and can be substituted in the same manner as heterocyclyl; together with tautomers where R1 is hydrogen.