Patent ID: 8580562
Filing Date: 2013-11-12
Classification: A61K,A61P,C12N

Abstract:
1. A cell proliferation inhibiting method, comprising: expressing in a cell an inhibitory siRNA which comprises a double-stranded siRNA composed of a sense siRNA having a base sequence with contiguous 20 to 30 bases of ZFAT mRNA and an anti-sense siRNA having a base sequence complementary to the base sequence of the sense siRNA to inhibit the expression of ZFAT gene and to inhibit proliferation of the cell; and wherein the double-stranded siRNA is a human ZFAT gene (hZFAT) siRNA comprising a sense siRNA having a base sequence as indicated by SQ ID NO. 3 and an anti-sense siRNA having a base sequence as indicated by SQ ID NO. 4,