Patent ID: 7741053
Filing Date: 2010-06-22
Classification: C07K,G01N

Abstract:
1. An antibody that binds to a metal ion-affinity peptide in a polypeptide, protein or protein fragment represented by the formula R 1 -Sp 1 -(His-Z 1 -His-Arg-His-Z 2 -His)-Sp 2 -R 2 , wherein (His-Z 1 -His-Arg-His-Z 2 -His) is the metal ion-affinity peptide, R 1 is hydrogen, a polypeptide, protein or protein fragment; Sp 1 is a covalent bond or a spacer comprising at least one amino acid residue; R 2 is hydrogen, a polypeptide, protein or protein fragment; Sp 2 is a covalent bond or a spacer comprising at least one amino acid residue; Z 1 is an amino acid residue selected from the group consisting of Ala, Arg, Asn, Asp, Gln, Glu, Ile, Lys, Phe, Pro, Ser, Thr, Trp, and Val; and Z 2 is an amino acid residue selected from the group consisting of Ala, Arg, Asn, Asp, Cys, Gin, Glu, Gly, Ile, Leu, Lys, Met, Pro, Ser, Thr, Tyr, and Val.