Patent ID: 6169088
Filing Date: 2001-01-02
Classification: A61K,A61P,C07D

Abstract:
A nitrogen-containing heterocyclic compound represented by formula (I): ##STR577## wherein V represents an oxygen atom or a sulfur atom; W represents 1,4-piperazinediyl or 1,4-homopiperazinediyl in which carbons on the ring may be substituted by 1-4 alkyl groups which may be the same or different; R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted heteroarylalkyl group; R.sup.2 represents a substituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted heteroarylalkyl group, --COR.sup.10 (wherein R.sup.10 has the same significance as R.sup.1) or --SO.sub.2 R.sup.11 (wherein R.sup.11 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alknyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted heteroarylalkyl group); R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a nitro group, a cyano group, --OR.sup.12 {wherein R.sup.12 has the same significance as R.sup.10 , or represents --COR.sup.13 (wherein R.sup.13 has the same significance as R.sup.10) or --SO.sub.2 R.sup.14 (wherein R.sup.14 has the same significance as R.sup.11)}, --NR.sup.15 R.sup.16 {wherein R.sup.15 has the same significance as R.sup.10, and R.sup.16 has the same significance as R.sup.10, or represents --SO.sub.2 R.sup.17 (wherein R.sup.17 has the same significance as R.sup.11) or ##STR578## (wherein X.sup.1 represents an oxygen atom or a sulfur atom; and R.sup.18 has the same significance as R.sup.10, or represents --OR.sup.19 (wherein R.sup.19 has the same significance as R.sup.11) or --NR.sup.20 R.sup.21 (wherein R.sup.20 and R.sup.21 have the same significance as R.sup.10, or R.sup.20 and R.sup.21 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)); or R.sup.15 and R.sup.16 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing heterocyclic group}, ##STR579## {wherein m represents an integer of 0-2; and when m is 0, R.sup.22 has the same significance as R.sup.10 ; when m is 1, R.sup.22 has the same significance as R.sup.11 ; and when m is 2, R.sup.22 has the same significance as R.sup.11, or represents --OR.sup.23 (wherein R.sup.23 has the same significance as R.sup.10 ) or --NR.sup.24 R.sup.25 (wherein R.sup.24 and R.sup.25 independently have the same significance as R.sup.10, or R.sup.24 and R.sup.25 are combLned together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)} or --COR.sup.26 {wherein R.sup.26 has the same significance as R.sup.10, or represents --OR.sup.27 (wherein R.sup.26 has the same significance as R.sup.10) or --NR.sup.28 R.sup.29 (wherein R.sup.28 and R.sup.29 independently have the same significance as R.sup.10, or R.sup.28 and R.sup.29 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)}; or any adjoining two of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are combined together to represent methylenedioxy or ethylenedioxy; or any adjoining two of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are combined together with the two adjoining carbon atoms to form a substituted or unsubstituted phenyl ring; or R.sup.3 and R.sup.4, R.sup.4 and R.sup.5, or R.sup.5 and R.sup.6 are combined together with the two adjoining carbon atoms to represent ##STR580## {wherein A represents an oxygen atom, a sulfur atom or --NR.sup.30 -- (wherein R.sup.30 has the same significance as R.sup.10); and Q.sup.1 has the same siqnificance as R.sup.10, or represents --NR.sup.31 R.sup.32 (wherein R.sup.31 and R.sup.32 independently have the same significance as R.sup.10, or R.sup.31 and R.sup.32 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group) or --SR.sup.33 (wherein R.sup.33 has the same significance as R.sup.10)}, or ##STR581## (wherein R.sup.34 and R.sup.35 independently have the same significance as R.sup.10 ; and Q.sup.2 represents an oxygen atom, a sulfur atom or .dbd.N--CN), or ##STR582## wherein R.sup.36 has the same significance as R.sup.10); Z represents a nitrogen atom; Y represents C--R.sup.8 (wherein R.sup.8 has the same significance as R.sup.7); and X represents a nitrogen atom, or a pharmaceutically acceptable salt thereof.