Patent ID: 6297356
Filing Date: 2001-10-02
Classification: A61K,C07K,G01N

Abstract:
A vertebrate telomere repeat binding factor 2 (TRF2) obtained by expressing a nucleic acid operatively linked to an expression control sequence in a cell; wherein said nucleic acid encodes a TRF2 comprising the amino acid sequence of SEQ ID NO:27, or an amino acid sequence that is at least 80% identical to that of SEQ ID:27; wherein said cell has been transformed or transfected by said nucleic acid; and wherein said TRF2 has the following characteristics:a) a basic N-terminal domain;b) a dimerization domain; anda Myb domain; wherein when the basic N-terminal domain is removed, the TRF detectable binds to the telomere repeat sequence (TTAGGG).sub.12.