Patent ID: 8309544
Filing Date: 2012-11-13
Classification: A61P,C07D

Abstract:
1. A compound of formula Ia or a pharmaceutically acceptable salt thereof: wherein A is selected from imidazole-2-yl, pyrrol-2-yl, and pyrid-2-yl; the group  is selected from 4-biphenyl, 3-quinolinyl, 6-(methoxycarbonyl)-2-naphthyl, 7-trifluoromethyl-3-quinolinyl, 2-naphthyl, 4-bromophenyl, 6,7-bis(cyano)-2-naphthyl, (3-methyl-4-phenyl)-phenyl, 4-(4-methoxyphenyl)phenyl, N-methyl-1,4-benzoxazin-7-yl, 4-(4-fluorophenyl)phenyl, 4-(1-pyrrolyl)phenyl, 4-(4-t-butylphenyl)phenyl, 2-(trifluoromethyl)-6-quinolinyl, 3-(trifluoromethyl)-7-isoquinolinyl, 3-(trifluoromethyl)-7-quinolinyl, 2-(trifluoromethyl)-6-quinoxalinyl, 2-(trifluoromethyl)-6-quinazolinyl, 2-oxo-6-benzoxazolinyl, 5-indolyl, pyrazolo[3,4-b]pyrid-5-yl, 3-chloro-7-cinnolinyl, 4-(3-pyridyl)phenyl, 4-(3-cyanophenyl)phenyl, 3-(phenyl)phenyl, 2-(cyclopropyl)-5-pyridyl, 6-chromonyl, 3,4-dimethylphenyl, 6-quinolinyl, 6-isoquinolinyl, 4-(phenoxy)phenyl, 7-(methoxy)-3-quinolinyl, 7-chloro-3-quinolinyl, 2-(1-pyrrolyl)-5-pyridyl, 2-methoxy-5-pyridyl, 2-hydroxy-5-pyridyl, 2-(dimethylamino)-5-pyridyl, and 1-naphthyl; R R and R