Patent ID: 6355796
Filing Date: 2002-03-12
Classification: C07D

Abstract:
A process for the preparation of a 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compound having the structural formula I whereinZ and Z1 are each independently C1-C8alkyl or Z and Z1 may be taken together with the nitrogen atom to which they are attached to form a 4- to 7-membered ring wherein Z and Z1 are represented by â€”(CH2)mâ€” where m is an integer of 3, 4, 5 or 6 or by â€”(CH2)2O(CH2)2â€”; and n is an integer of 1, 2, 3, 4, 5 or 6, which process comprises:(a) reacting a &bgr;-amino-&bgr;-(perfluoroalkyl)acrylate compound having the structural formula II wherein n is as described above, and Z2 is C1-C6alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups, with a base and a carbamoyl chloride compound having the structural formula III wherein Z and Z1 are as described above to form a urea compound having the structural formula IV (b) reacting the formula IV urea with a phosphorous pentahalide or oxalyl halide.