Patent ID: 8455623
Filing Date: 2013-06-04
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody that specifically binds human MET, the antibody selected from the group consisting of: (a) an antibody comprising (i) a heavy chain CDR1 comprising GFSLSTSGMVVS (SEQ ID NO:3), a heavy chain CDR2 comprising FISWDDDKYYSTSLKT (SEQ ID NO:4), and a heavy chain CDR3 comprising EPGRYGGYYFDY (SEQ ID NO:5); and (ii) a light chain CDR1 comprising RASQTISHYLA (SEQ ID NO:8), a light chain CDR2 comprising AASILQS (SEQ ID NO:9), and a light chain CDR3 comprising QQYSGFPV (SEQ ID NO:10); (b) an antibody comprising (i) a heavy chain CDR1 comprising GGSISGYYWS (SEQ ID NO:13), a heavy chain CDR2 comprising EIYYAGSTLYNPSLKG (SEQ ID NO:14), and a heavy chain CDR3 comprising HYGLDWFGDTGMDV (SEQ ID NO:15); and (ii) a light chain CDR1 comprising SGDNLGDKYVH (SEQ ID NO:18), a light chain CDR2 comprising DDNERPSG (SEQ ID NO:19), and a light chain CDR3 comprising SAYGSHSGT (SEQ ID NO:20); and (c) an antibody comprising (i) a heavy chain CDR1 comprising GGSISGYYWS (SEQ ID NO:13), a heavy chain CDR2 comprising EIYYAGSTLYNPSLKG (SEQ ID NO:14), and a heavy chain CDR3 comprising HYGLDWFGDTGMDV (SEQ ID NO:15); and (ii) a light chain CDR1 comprising SGDNLGEQYVH (SEQ ID NO:23), a light chain CDR2 comprising DDSERPSG (SEQ ID NO:24), and a light chain CDR3 comprising QSYTFYPNSR (SEQ ID NO:25).