Patent ID: 6670354
Filing Date: 2003-12-30
Classification: A61K,A61P,C07D

Abstract:
A method to treat a subject for nonviral hematopoietic disorder which method comprisesadministering to said subject in need of such treatment an amount effective to treat said disorder of a compound of the formula Z-linker-Zâ€²â€ƒâ€ƒ(1) or pharmaceutically acceptable salt thereofwherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; Zâ€² may be embodied in a form as defined by Z above, or alternatively may be of the formula â€”N(R)â€”(CR2)nâ€”X â€ƒwherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; â€œlinkerâ€  represents a bond, alkylene (1-6C) wherein said alkylene may further comprise aryl, fused aryl, and/or oxygen atoms contained in an alkylene chain.