Patent ID: 6096535
Filing Date: 2000-08-01
Classification: A61K,A61P,C07K,C12N,G16H,Y02A

Abstract:
A recombinant viral vector or plasmid comprising and expressing in vivo the nucleotide sequence of the FIPV S gene having the nucleotide sequence of the 79-1146 FIPV strain S gene modified in a codon selected from the group consisting of:(i) the codon coding for Asp at position 568;(ii) the codon coding for Asp at position 591;(iii) the codon coding for Asp at position 643;(iv) the codon coding for Arg at position 649; and(v) the codon coding for Arg at position 656;said modification being such that the modified S protein expressed by said modified sequence no longer induces enhancing antibodies.