Patent ID: 7049072
Filing Date: 2006-05-23
Classification: A61K,C12N,C12Q,G01N

Abstract:
1. A method for diagnosing a leukemic disease state in a patient, the method comprising: (a) providing a gene expression profile of a patient's bone marrow derived isolated pluri-differentiated mesenchymal progenitor cell of unknown state, wherein the isolated pluri-differentiated mesenchymal progenitor cell simultaneously expresses a plurality of genes at the protein level that are markers for multiple cell lineages, wherein the multiple cell lineages comprise at least four different mesenchymal cell lineages, and wherein each of the markers is specific for a single cell lineage; and (b) comparing the patient's gene expression profile to a reference gene expression profile obtained from a normal bone marrow derived pluri-differentiated mesenchymal progenitor cell, wherein the reference gene expression profile comprises an expression value of a target gene selected from the group consisting of human mRNA for cartilage specific proteoglycan,