Patent ID: 7498171
Filing Date: 2009-03-03
Classification: A61K,A61P,C12N

Abstract:
1. A method for promoting the differentiation of mammalian CD34+ or CD133+ hematopoietic stem cells to CFU-GM (colony-forming units−granulocyte/macrophage) while inhibiting their differentiation to BFU-E (blast-forming units−erythrocyte), said method comprising: contacting said stem cells with an amino-substituted thalidomide analog under conditions under which said stem cells differentiate, wherein the amino-substituted thalidomide analog is selected from the group consisting of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione and 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, and wherein said contacting detectably increases the number of CFU-GM and detectably decreases the number of BFU-E differentiated from said stem cells relative to the numbers of CFU-GM and BFU-E differentiated from mammalian CD34+ or CD133+ hematopoietic stem cells not contacted with said amino-substituted thalidomide analog.