Patent ID: 9198879
Filing Date: 2015-12-01
Classification: A61K,A61P

Abstract:
1. A method for treating a metabolic disorder in a subject comprising oral administration of a nordihydroguiaretic acid (NDGA) composition to the subject, wherein the NDGA composition is comprised in a multi-modal drug delivery system defined by multi-modal NDGA delivery kinetics, and wherein the multi-modal drug delivery system comprises: a first portion of the NDGA composition that is releasable at a peak pH of 1 to 4, and a second portion of the NDGA composition that is a releasable at a peak pH of 5.0 to 7.5, wherein over 30% of a total portion of NDGA present in the NDGA composition is present in the second portion, and over 90% of the total portion of NDGA present in the NDGA composition is releasable at a pH of 7.5 or lower, and wherein the structure of the NDGA comprised in the first portion or the second portion of the single dose of NDGA is given by Formula I: