Patent ID: 6156336
Filing Date: 2000-12-05
Classification: A61K,Y10S

Abstract:
A process for producing active ingredient reservoirs from active-ingredient-containing layered articles or discs with uniform or regionally varying constitution within the layer for use in transdermal therapeutic systems, said process comprising:(a) die casting or extruding polymers or polymer containing preparations into an elongated article having an active ingredient-containing core and an inert enveloping surface corresponding to a contour of a layered article to be produced and a cross-sectional constitution corresponding to a uniform or regionally varying constitution of the layered article; and(b) converting said elongated article into single discs having a thickness of 10-2000 .mu.m by detaching said discs from said elongated article perpendicularly to a longitudinal axis of said elongated article, wherein detachment is achieved by planing, cutting, sawing, pinching, splitting or by using high-energy radiation or particle beam.