Patent ID: 8142783
Filing Date: 2012-03-27
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a condition involving an inflammatory reaction in which VAP-1 adhesion plays a role in mediating the transmigration and infiltration of leukocytes from the blood into a site of inflammation, said method comprising: administering to a patient who has an inflammatory reaction in which VAP-1 adhesion plays a role in mediating the transmigration and infiltration of leukocytes from the blood into a site of inflammation an efficient amount of a pharmaceutical composition comprising a fully human anti-VAP-1 antibody or VAP-1 binding fragment thereof, comprising a heavy chain polypeptide, wherein the heavy chain polypeptide comprises, in the following order, the CDR sequences set forth as SEQ ID NOS: 1, 2, and 3 and a light chain polypeptide, wherein the light chain polypeptide comprises, in the following order, the CDR sequences set forth as SEQ ID NOS: 24, 25, and 26, characterized in that it is fully human.