Patent ID: 7015347
Filing Date: 2006-03-21
Classification: A61L,A61P,C07C

Abstract:
1. A compound containing at least one S-nitrosyl group, at least one free thiol group or free alcohol group, optionally one or more functional groups selected from the group consisting of alcohols, thiols, amides, thioamides, aldehydes, ketones, halogens, double bonds, triple bonds and aryl groups wherein the compound has a molecular weight of at least 225 atomic mass units, wherein the S-nitrosyl group is stabilized by the free alcohol group or the free thiol group and wherein the compound has a half-life for NO-release that is at least two times as great as the corresponding compound without the free thiol group or free alcohol group, with the proviso that the polythiol or thioalcohol is not a polypeptide, an unsubstituted straight chained or branched dithiolated alkane, an unsubstituted straight chained or branched thioalkanol, a polythiolated polysaccharide, or a polymer with pendant thiol groups and is not represented by one of the following structural formulas: wherein each Ra is —H or methyl and is independently chosen.