Patent ID: 9161933
Filing Date: 2015-10-20
Classification: A61K,A61P

Abstract:
1. A solid pharmaceutical composition comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, wherein amlodipine or a pharmaceutically acceptable salt thereof is of granular form, and losartan or a pharmaceutically acceptable salt thereof is of granule form, wherein the granule of amlodipine or a pharmaceutically acceptable salt thereof and the granule of losartan or a pharmaceutically acceptable salt thereof are separated from each other; wherein the composition comprises losartan or a pharmaceutically acceptable salt thereof in an amount ranging from 5 to 22.3% by weight based on the total weight of the composition; wherein the composition comprises a granule form of losartan of which the percentage of a fine granule passing through a 75 μm mesh is below 50%; wherein the dissolution rate of amlodipine in the solid pharmaceutical composition is 80% or more thereof in 30 minutes at a pH range of 1.0 to 2.0; and wherein the dissolution rate of losartan in the solid pharmaceutical composition is 80% or more thereof in 30 minutes at a pH range of 1.0 to 2.0.