Patent ID: 8551475
Filing Date: 2013-10-08
Classification: A61K,A61P,C12N

Abstract:
1. A method of reducing an immune response to a transplanted donor heart in a recipient subject comprising: administering isolated adult bone marrow progenitor cells to the transplanted donor heart, wherein said adult bone marrow progenitor cells are isolated from the recipient subject's bone marrow and are lineage negative and c-kit positive, and administering isolated vascular progenitor cells to the transplanted donor heart, wherein said vascular progenitor cells are isolated from the recipient subject's myocardial tissue and are lineage negative, c-kit positive, and vascular endothelial growth factor receptor 2 (VEGFR2) positive, wherein said bone marrow progenitor cells generate immunocompatible myocardium and immunocompatible myocardial vessels and said vascular progenitor cells generate immunocompatible vessels following their administration, thereby reducing the immune response to said transplanted donor heart.