Patent ID: 6011006
Filing Date: 2000-01-04
Classification: A61K

Abstract:
A method for treating migraine, Type II diabetes, sepsis, inflammation and/or vasomotor disturbances, the method comprising administering to a patient in need thereof an effective amount of a compound of formula (I)A.sup.1 -A.sup.2 -A.sup.3 -A.sup.4 -A.sup.5 -A.sup.6 -Y (I)whereinA.sup.1 is Arg, Lys, His, D-Arg, D-Lys, D-His, acylated Arg, acylated Lys, acylated His, acylated D-Arg, acylated D-Lys or acylated D-His;A.sup.2 is Tyr, Trp, Phe, D-Tyr, D-Trp or D-Phe;A.sup.3 is Tyr, Trp, Phe, D-Tyr, D-Trp or D-Phe;A.sup.4 is Lys, Arg, His, D-Arg, D-Lys or D-His;A.sup.5 is Phe, Tyr, Trp, IIe, D-Phe, D-Tyr, D-Trp or D-IIe;A.sup.6 is Arg, Lys, His, D-Arg, D-Lys or D-His; andY is OH or NH.sub.2or a pharmaceutically acceptable salt thereof.