Patent ID: 7582633
Filing Date: 2009-09-01
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein each m is independently an integer from 0 to 4; each n is independently an integer from 0 to 2; each s is independently an integer from 1 to 3; each t is independently an integer from 1 to 3; q is 0 or 1; r is 0 or 1; Z is O, S, or NR X—Y is N—CR W is heteroaryl selected from the group consisting of: Ar is phenyl, naphthyl, or heteroaryl optionally substituted with one to five R R R wherein R c is —(CH 2 ) m CO 2 H, —(CH 2 ) m CO 2 C 1-3 alkyl, —(CH 2 ) m -Z-(CH 2 ) p CO 2 H, or —(CH 2 ) m -Z-(CH 2 ) p CO 2 C 1-3 alkyl, wherein each (CH 2 ) methylene group is optionally substituted with one or two substituents selected from the group consisting of C 1-4 alkyl, fluorine, oxo, and hydroxy; and wherein said R 1 heteroaryl ring is optionally substituted with one substituent independently selected from the group consisting of cyano, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulfonyl, and trifluoromethyl; each R each R in which phenyl, naphthyl, heteroaryl, cycloalkyl, and heterocyclyl are optionally substituted with one to three substituents independently selected from halogen, hydroxy, C each R wherein alkyl, phenyl, heteroaryl, and cycloalkyl are optionally substituted with one to three groups independently selected from halogen, trifluoromethyl, C R R each R