Patent ID: 6066734
Filing Date: 2000-05-23
Classification: C07D,Y02P

Abstract:
A process for the preparation of a chloropyrimidine compound of the formula: ##STR10## wherein X and X' each, independently represents C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, or Cl with the proviso that at least one X and X' represents Cl;Y represents C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, or Cl; andZ represents H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, F, Cl, or Brwhich comprises contacting an hydroxypyrimidine compound of the formula: ##STR11## wherein Q and Q' each, independently represents C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, Cl, or OH with the proviso that at least one of Q and Q' represents OH;Y represents C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, or Cl; andZ represents H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 fluoroalkoxy, C.sub.1 -C.sub.4 alkylthio, CN, F, Cl, or Brwith, based on the number of moles of hydroxy group in the hydroxypyrimidine compound, at least about one to about two moles of phosphorus oxychloride, at least about one mole of phosphorus trichloride, and at least about one mole of a trialkylamine compound of Formula III:R.sub.3 Nwherein each R independently represents a C.sub.1 -C.sub.8 alkyl group and said trialkylamine compound contains up to about 15 carbon atoms and heating.