Patent ID: 6172072
Filing Date: 2001-01-09
Classification: A61P,C07D

Abstract:
A benzamide of formula I ##STR158##or a tautomeric or isomeric form thereof, or its physiologically tolerated salt whereinR.sup.1 is hydrogen, C.sub.1 -C.sub.6 -alkyl, O--C.sub.1 -C.sub.6 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH, COO--C.sub.1 -C.sub.4 -alkyl, --NHCO--C.sub.1 -C.sub.4 -alkyl, --NHCO-phenyl, --CONHR.sup.8, NHSO.sub.2 --C.sub.1 -C.sub.4 -alkyl, --NHSO.sub.2 -phenyl, --SO.sub.2 --C.sub.1 -C.sub.4 -alkyl or --SO.sub.2 -phenyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.6 -alkyl, O--C.sub.1 -C.sub.6 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH, COO--C.sub.1 -C.sub.4 -alkyl, --NHCO--C.sub.1 -C.sub.4 -alkyl, --NHCO-phenyl, --CONHR.sup.8, NHSO.sub.2 --C.sub.1 -C.sub.4 -alkyl, --NHSO.sub.2 -phenyl, --SO.sub.2 --C.sub.1 -C.sub.4 -alkyl or --SO.sub.2 -phenyl, orR.sup.1 and R.sup.2 are, together, a chain --CH.dbd.CH--CH.dbd.CH--, which is unsubstituted or carries one or two substituents R.sup.6,R.sup.3 is hydrogen, chlorine, bromine, fluorine, C.sub.1 -C.sub.6 -alkyl, phenyl, NHCO--C.sub.1 -C.sub.4 -alkyl, NO.sub.2 or NH.sub.2,R.sup.4 is C.sub.1 -C.sub.6 -alkyl, which is unsubstituted or carries a phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indolyl, pyridyl or naphthyl ring which ring, in turn, is unsubstituted or substituted by one or two radicals selected from the group consisting of C.sub.1 -C.sub.4 -alkyl, --O--C.sub.1 -C.sub.4 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH, COO--C.sub.1 -C.sub.4 -alkyl, --CONHR.sup.8, --NHCO--C.sub.1 -C.sub.4 -alkyl, --NHCO-phenyl, --NHSO.sub.2 --C.sub.1 -C.sub.4 -alkyl, --NHSO.sub.2 -phenyl, --SO.sub.2 --C.sub.1 -C.sub.4 -alkyl and --SO.sub.2 -phenyl, ##STR159##R.sup.6 is hydrogen, C.sub.1 -C.sub.6 -alkyl, --O--C.sub.1 -C.sub.6 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH or COO--C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen or C.sub.1 -C.sub.6 -alkyl,R.sup.9 is hydrogen or C.sub.1 -C.sub.6 -alkyl which is unsubstituted or substituted by a phenyl ring which optionally carries a radical R.sup.11, and which is optionally substituted by ##STR160## ##STR161##R.sup.10 is hydrogen or C.sub.1 -C.sub.6 -alkyl,R.sup.11 is hydrogen, C.sub.1 -C.sub.6 -alkyl, --O--C.sub.1 -C.sub.6 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH or COO--C.sub.1 -C.sub.4 -alkyl,R.sup.12 is hydrogen or a --C.sub.0-4 -alkyl chain which is unsubstituted or substituted by a phenyl ring which, in turn, is unsubstituted or carries one or two radicals R.sup.11,X is --NH--CO--, --N.dbd.CH--,n is the number 0, 1 or 2, andm is the number 0, 1 and 2.