Patent ID: 6613776
Filing Date: 2003-09-02
Classification: A61P,C07D

Abstract:
A composition comprising a pharmaceutically acceptable carrier and a compound of formula V: or a pharmaceutically acceptable salt thereof, wherein:Z1 is N, CRa, or CH, and Z2 is N or CH, provided that one, and only one, of Z1 or Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl pyridinyl, pyridazinyl, pyridazinyl, pyrazinyl 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from â€”R1, any non-ortho carbon position on Ring C is optionally and independently substituted by â€”R5, and two adjacent substituents on Ring C are optionally taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-6 membered ring having 0-3 heteroatoms selected from oxygen, sulfur or nitrogen said fused ring being optionally substituted by halo, oxo, or â€”R8; Ring D is a 5-7 membered monocycle ring or 8-10 membered bicycle ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, said heteroaryl or heterocyclyl ring having 1-4 ring heteroatoms selected from nitrogen, oxygen or sulfur, wherein Ring D is substituted at any substitutable ring carbon by oxo or â€”R5, and at any substitutable ring nitrogen by â€”R4 provided that when Ring D is a six-membered aryl or heteroaryl ring, â€”R5 is hydrogen at each ortho carbon position of Ring D; R1 is selected from -halo, â€”CN, â€”NO2, Tâ€”Vâ‰ R6, phenyl, 5-6 membered heteroaryl ring, 5-6 membered heterocyclyl ring, or C1-6 aliphatic group, said phenyl, heteroaryl, and heterocyclyl rings each optionally substituted by up to three groups independently elected from halo, oxo, or â€”R8; said C1-6 aliphatic group optionally substituted with halo, cyano, nitro, oxygen, or R1 and an adjacent substituent taken together with their interviewing atoms form said ring fused to Ring C; Rx and Ry are independently selected from Tâ€”R3 or Rx and Ry are taken together with their interviewing atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered rink having 0-3 ring heteroatoms selected from oxygen; sulfur, or nitrogen, wherein any substitutable carbon on said fused ring formed by Rx and Ry is substituted by oxo Tâ€”R3, and any substitutable nitrogen on said ring formed by Rx and Ry is sustained by Rx Ry is substituted by R4; T is a valence bond or a C1-4 alkylidene chain; R2 and R2â€² are independently selected from â€”R, â€”Tâ€”Wâ€”R6, or R2 and R2â€² are taken together with their intervening atoms to form a fused, 5-8 membered, unsaturated or partially unsaturated, ring having 0-3 ring heteroatoms selected from nitrogen oxygen; or sulfur, wherein each substitutable carbon on said fused ring formed by R2 and R2â€² is substituted by halo, oxo, â€”CN, â€”NO2, â€”R7, or â€”Vâ€”R6, and any substitutable nitrogen on said ring formed by R2 and R2â€² is substituted by R4; R3 is selected from â€”R, â€”halo, â€”OR, â€”C(&boxH;O)R, â€”CO2R, â€”COCOR, â€”COCH2COR, â€”NO2, â€”CN, â€”S(O)R, â€”S(O)2R, â€”SR, â€”N(R4)2, â€”CON(R7)2, â€”SO2N(R7)2, â€”OC(&boxH;O)R, â€”N(R7)COR, â€”N(R7)CO2(optionally substituted C1-6 aliphatic), â€”N(R4)N(R4), C&boxH;NN(R2) C&boxH;Nâ€”OR, â€”N(R1)CON(R7)2, â€”N(R7)SO2N(R7)2, N(R4)SO2R, or â€”OC(&boxH;O)N(R7)2; each R is independently selected from hydrogen or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; each R4 is independently selected from â€”R7, COR7, â€”CO2(optionally substituted C1-6 aliphatic) CON(R7)2, or â€”SO2 R7, or two R4 on the same nitrogen are taken together to form a 5-8 membered heterocyclyl or heteroaryl ring; each R5 is independently selected from â€”R7, halo â€”OR, â€”C(&boxH;O)R,â€”CO2R, â€”COCOR, â€”NO2 â€”CN â€”S(O)R, â€”SO2R, â€”SR, â€”N(R4)2, â€”CON(R4), â€”SO2N(R4)2, â€”OC(&boxH;O)R, â€”N(R4)COR, â€”N(R)CO2(optionally substituted C1-6 aliphatic), â€”N(R4)N(R4)2, â€”C&boxH;NN(R4)2, C&boxH;Nâ€”OR, â€”N(R4)CON(R4)2, â€”N(R4)SO2N(R4)2, N(R4)SO2R, or â€”OC(&boxH;O)N(R4)2, or R5 and an adjacent substituent taken together with their intervening atoms from said ring fused Ring C; V is â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”N(R6)SO2â€”, â€”SO2N(R6)â€”, â€”N(R6)â€”, â€”Câ€”, â€”CO2â€”, â€”N(R6)COâ€”, â€”N(R6)C(O)Oâ€”, â€”N(R6)CON(R6)â€”, â€”N(R6)SO2N(R6)â€”, â€”N(R6)N(R6, â€”C(O)N(R6â€”, OC(O)N(R6)â€”, â€”C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2SO2, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)2N(R6)â€”, â€”C(R6),N(R6)C(O)â€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)SO2N(R6)â€”, or â€”C(R6)2N(R6)CON(R6)â€”; W is â€”C(R6)2O, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2â€”SO2â€”, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”, â€”COâ€”, â€”CO2â€”, â€”C(R6)OC(O)â€”, â€”C(R6)OC(O)N(R6)â€”, â€”C(R6)2N(R6)COâ€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, C(R6)2N(R6)CON (R6)â€”, or â€”CON(R6); each R6 is independently selected from hydrogen, an optionally substituted C1-4 aliphatic group, or two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to form a 5-6 membered heterocyclyl or heteroaryl ring; each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group or two R7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclyl or heteroaryl ring; each R8 is independently selected from an optionally substituted aliphatic group, â€”OR6, â€”SR6, COR6, â€”SO2R6, â€”N(R6)2, â€”N(R6)N(R6)2, â€”CN; â€”NO2, â€”CON(R6)2, or â€”CO2R6; and Ra is selected from halo, â€”OR, â€”C(&boxH;O)R, â€”CO2R, â€”COCOR, â€”NO2, â€”CN, â€”S(O)R, â€”SO2R, â€”SR, â€”N(R4), â€”CON(R4)2, â€”SO2N(R4)2, â€”OC(&boxH;O)R, â€”N(R4)COR, â€”N(R4)CO2(optionally substituted C1-6 aliphatic), â€”N(R6)N(R4)2, â€”C&boxH;NN(R4)2, â€”C&boxH;Nâ€”OR, â€”N(R4)CON(R4)2, â€”N(R4)SO2N(R4)2, â€”N(R4)SO2R â€”OC(&boxH;O)N(R4)2, or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms.