Patent ID: 6022500
Filing Date: 2000-02-08
Classification: B01J

Abstract:
A method of preparing, a polymer microsphere containing an encapsulated substance, comprising the steps of:(a) admixing a first solution comprising at least one polymerizing agent in an aqueous buffer solution with a second solution comprising at least one surfactant dissolved in a liquid hydrocarbon solvent to form a reversed micellar solution;(b) dissolving at least one monomer capable of being polymerized in the reversed micellar solution to provide an internal reaction medium comprising the admixture;(c) polymerizing the monomer to form a polymer microsphere, wherein density of the prepared polymer microsphere is controlled, and the polymer microsphere is isolated;(d) sonicating the prepared polymer microsphere; and(e) filling the sonicated polymer microsphere by contacting the sonicated polymer microsphere with solution of a substance.