Patent ID: 9192624
Filing Date: 2015-11-24
Classification: A61K,A61L,D01D,D01F

Abstract:
1. A method for promoting mesenchymal stem cell differentiation, which comprises: (a) cultivating a mesenchymal stem cell in the presence of a medical material comprising a polyamino acid, or (b) transplanting a medical material comprising a polyamino acid to a subject in need thereof, wherein the medical material has a cell adhesion suppressive effect, and wherein the polyamino acid consists of: (i) one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue containing a protecting group in the side chain, and a glutamic acid residue containing a protecting group in the side chain; or (ii) two kinds of amino acid residues selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain, excluding polyamino acids consisting of two kinds of amino acid residues of (1) glutamic acid and alanine and (2) lysine and phenylalanine; wherein the medical material is a fiber structure, wherein the polyamino acid is: poly-L-alanine; poly-L-valine; poly-N poly-L-alanine/γ-methyl-L-glutamic acid; poly-L-leucine/γ-methyl-L-glutamic acid; poly-L-alanine/N poly-L-leucine; poly-L-valine/γ-methyl-L-glutamic acid; poly-L-isoleucine/γ-methyl-L-glutamic acid; poly-L-phenylalanine/γ-methyl-L-glutamic acid; poly-L-valine/N poly-L-isoleucine/N poly-L-valine/L-phenylalanine.