Patent ID: 8771705
Filing Date: 2014-07-08
Classification: A61K,C12N

Abstract:
1. A method for inhibiting growth and/or metastasis of a cancer cell, cornprising: administering to a mammal in need thereof an effective amount of mesenchymal stem cells comprising a transgene encoding human papillomavirus (HPV) oncogenic protein selected from the group consisting of HPV E7, HPV E6 and a combination thereof, wherein the mesenchymal stem cells are immortal and show no signs of neoplastic transformation; administering to the mammal a vaccine composition comprising an effective amount of an immunogenic protein capable of eliciting an antibody specific against the HPV oncogenic protein selected from the group consisting of HPV E7, HPV E6 and a combination thereof; wherein the mesenchymal stem cells fuse with the cancer cell in the mammal, and wherein the fusion results in the expression of the HPV oncogneic protein selected from the group consisting of HPV E7, HPV E6 and a combination thereof on the cancer cell in the mammal; and wherein the antibody specific against the HPV oncogenic protein selected from the group consisting of HPV E7, HPV E6 and a combination thereof effects the death of the cancer cell expressing the HPV concogenic protein selected from the group consisting, of HPV E7, HPV E6 and a combination thereof in the mammal.