Patent ID: 6017509
Filing Date: 2000-01-25
Classification: A61K,C07B,C07K,Y10S

Abstract:
A reagent comprising:a) a somatostatin receptor-binding peptide having a formulacyclo-A.sup.4 -B.sup.1 B.sup.2 B.sup.3 B.sup.4 -C.sup.4 -whereinB.sup.1 is D-Phe, L-Phe, D-Tyr, L-Tyr, D-Nal, L-Nal, or Ain;B.sup.2 is D-Trp, or L-Trp;B.sup.3 is D-Lys, L-Lys, Hly, Achxa, Amf, Aec, Apc, Aes, or Aps;B.sup.4 is Thr, Ser, Val, Phe, Ile, Abu, Nle, Leu, Nva or Aib;C.sup.4 is an L-amino acid;A.sup.4 is a lipophilic D-amino acid, a lipophilic L-(.alpha.-N-alkyl)amino acid, or L-proline;wherein A.sup.4 and C.sup.4 are covalently linked through an amino terminus of A.sup.4 and a carboxyl terminus of C.sup.4 to form a cyclic peptide; andb) a radiolabel-binding moiety covalently linked to C.sup.4.