Patent ID: 7435412
Filing Date: 2008-10-14
Classification: A61P,C07K,G01N

Abstract:
1. A method of treating chronic lymphocytic leukemia (CLL) comprising administering to a patient suffering from CLL an antibody or antigen-binding fragment thereof that specifically binds to OX-2/CD200, wherein said antibody or antigen-binding fragment thereof comprises a light chain CDR1 having the sequence set forth in SEQ ID NO: 5; a light chain CDR2 having the sequence set forth in SEQ ID NO: 21; a light chain CDR3 having the sequence set forth in SEQ ID NO: 29; a heavy chain CDR1 having the sequence set forth in SEQ ID NO: 50; a heavy chain CDR2 having the sequence set forth in SEQ ID NO: 69; and a heavy chain CDR3 having the sequence set forth in SEQ ID NO: 88.