Patent ID: 6544498
Filing Date: 2003-04-08
Classification: A23G,A23J,A61K,A61P,A61Q,Y10S

Abstract:
A method of preventing and ameliorating a periodontal disease comprising administrating a milk-derived basic protein to a candidate for the prevention and amelioration of the periodontal disease in an effective amount to prevent and ameliorate the disease, (a) said protein having a molecular weight distribution of 3,000-80,000 and an isoelectric point within a range of 7.5-11, (b) said protein's main components being lactoferrin and lactoperoxidase, (c) said protein containing, as its amino acid constituent in protein, basic amino acids by more than 15 weight percents, and (d) said protein being obtained by passing a milk or milk-derived ingredient through cation-exchange resin and performing gradient elution using phosphate buffer of pH 7 containing 0. 1M sodium chloride and phosphate buffer of pH 7 containing 1.0M sodium chloride.