Patent ID: 7834170
Filing Date: 2010-11-16
Classification: A61K,A61P,C12N,C12Y,G16B

Abstract:
1. A pool comprised of a first siRNA and a second siRNA, wherein said first siRNA consists of a first duplex region and either no overhangs or at least one overhang, wherein each overhang has up to six bases, wherein said first duplex region consists of 19 base pairs that form a first sense region and a first antisense region, wherein said first antisense region is complementary to a first region of a target, and said second siRNA consists of a second duplex region and either no overhangs or at least one overhang, wherein each overhang has up to six bases and said second duplex region consists of 19 base pairs that form a second sense region and a second antisense region, wherein said second antisense region is complementary to a second region of said target, and each of said first sense region and said second sense region satisfy the following criteria: an A base at position 19 and a U base at position 10.