Patent ID: 6103762
Filing Date: 2000-08-15
Classification: A61K,A61P,A61Q,C07D

Abstract:
Biaromatic compounds connected by a propynylene or allenylene bond corresponding to the following formula (I): ##STR18## wherein Ar represents a radical of the following formula (a): ##STR19## R.sub.1 represents --CH.sub.3, --CH.sub.2 --OR.sub.6, --OR.sub.6 or --COR.sub.7,R.sub.2 and R.sub.3 taken together, form a 5- or 6-membered ring optionally substituted by at least one methyl,R.sub.4 represents aryl,R.sub.5 represents H, a halogen, linear or branched C.sub.1 -C.sub.20 alkyl or an --OR.sub.8 radical,R.sub.6 represents H, lower alkyl or a --COR.sub.9 radical,R.sub.7 represents H, lower alkyl, ##STR20## or --OR.sub.10, R.sub.8 represents H, lower alkyl or --COR.sub.9,R.sub.9 represents lower alkyl,R.sub.10 represents H, linear or branched C.sub.1 -C.sub.20 alkyl, alkenyl, mono- or polyhydroxyalkyl, optionally substituted aryl or aralkyl, or a sugar residue,r' and r"" represent H, lower alkyl, mono- or polyhydroxyalkyl, optionally substituted aryl, or an amino acid or sugar residue,X represents a divalent radical which, from right to left or vice versa, has the formula: ##STR21## R.sub.11 representing H or --OR.sub.6, R.sub.6 having the same meaning as above,R.sub.12 representing H or lower alkyl, orR.sub.11 and R.sub.12 taken together, form an oxo (.dbd.O) radical,and the salts of the compounds of formula (I), when R.sub.1 represents a carboxylic acid functional group, and the optical and geometrical isomers of the compounds of formula (I).