Patent ID: 6825204
Filing Date: 2004-11-30
Classification: A61K,A61P,C07B,C07D

Abstract:
An N-substituted 3-hydroxy-4-pyridinone compound of the formula (I): or a pharmaceutically acceptable salt thereof, or prodrug thereof, wherein:X is selected from the group: CH2, C(O), C(S), P(O)R3R4, SO2, C(&boxH;NH)NH, C(O)NH, and C(S)NH; R1 and R2 are independently selected from: H, C1-C10 alkyl substituted with 0-5 R5, C2-C10 alkenyl substituted with 0-5 R5, aryl substituted with 0-3 R5, and heteroaryl substituted with 0-3 R5; R3 and R4 are independently selected from: C1-C10 alkyl substituted with 0-5 R5, C2-C10 alkenyl substituted with 0-5 R5, aryl substituted with 0-3 R5, and heteroaryl substituted with 0-3 R5, or R3 and R4 may be taken together to form a C5-C7 cyclic alkyl group optionally interrupted with O or NR6; R5 is selected from: OH, C(&boxH;O)R6, C(&boxH;O)OR6, C(&boxH;O)NR6R7, PO(OR6)(OR7), and S(O)2OR6; and R6 and R7 are independently selected from: H, C1-C10 alkyl, and aryl.