Patent ID: 6214999
Filing Date: 2001-04-10
Classification: C07C,Y02P

Abstract:
A process for preparing 4'-bromomethyl-biphenyl derivatives of general formula: ##STR6##in which R represents:a cyano groupa group:--CO.sub.2 R.sub.1 or --CONR.sub.2 R.sub.3in which R.sub.1, R.sub.2 and R.sub.3, which may be identical or different, represent hydrogen or a linear or branched C.sub.1 -C.sub.6 alkyl group which can be optionally substituted with a halogen atom, a hydroxyl, amino, C.sub.1 -C.sub.4 alkoxy group or with 1 to 3 phenyl groups optionally substituted with 1 to 3 groups chosen from halogen atoms and hydroxyl, nitro, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy groups,a tetrazolyl group of general formula: ##STR7##in which R.sub.4, in position 1 or 2 of the tetrazolyl group, represents hydrogen or a protecting group, wherein a brominating agent chosen from bromine, N-bromoacetamide, N-bromophthalimide, N-bromomaleimide, an N-bromosulphonamide, N-bromosuccinimide, 1,3-dibromo-5,5-dimethylhydantoin and a hydrobromic acid/alkali metal bromate system is reacted, in a two-phase medium and under the effect of a photo-irradiation, with a biphenyl derivative of general formula: ##STR8##in which R has the same meaning as above, which gives the desired compound.