Patent ID: 7553841
Filing Date: 2009-06-30
Classification: A61P,C07D

Abstract:
1. A compound of formula IIa: wherein: X is C; R R R R Z is selected from C and N; R (a) hydrogen, (b) —C (c) —C (d) —C (e) —(C (f) hydroxy, (g) heterocycle, (h) —CN, (i) —NR (j) —NR (k) —NR (l) —COR (m) —CONR (n) phenyl; where said alkyl and cycloalkyl are unsubstituted or substituted with 1-7 substituents, and where said substituents are independently selected from: halo, hydroxy, —O—C R R (a) C (b) —O—C (c) —CO—C (d) —S—C (e) -pyridyl, which is unsubstituted or substituted with one or more substituents selected from: halo, trifluoromethyl, C (f) fluoro, (g) chloro, (h) bromo, (i) —C (j) —O—C (k) phenyl, which is unsubstituted or substituted with one or more substituents selected from: halo, trifluoromethyl, C (l) —O-phenyl, which is unsubstituted or substituted with one or more substituents selected from: halo, trifluoromethyl, C (m) —C (n) —O—C (o) -heterocycle, (p) —CN, and (q) —COR R (a) 1H-indene, (b) 2,3-dihydro-1H-indene, (c) 2,3-dihydro-benzofuran, (d) 1,3-dihydro-isobenzofuran, (e) 2,3-dihydro-benzothiofuran, (f) 1,3-dihydro-isobenzothiofuran, (g) 6H-cyclopenta[d]isoxazol-3-ol (h) cyclopentane, and (i) cyclohexane, where the ring formed is unsubstituted or substituted with 1-5 substituents independently selected from: halo, trifluoromethyl, hydroxy, C R or a pharmaceutically acceptable salt or individual diastereomer thereof.