Patent ID: 6855716
Filing Date: 2005-02-15
Classification: A61P,C07D

Abstract:
1. A dihydropyrimidine compound of the following formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof: wherein Z represents a group of the following formula (Z1), which is bonded to the nitrogen atom at the symbol “*”: wherein B wherein R X A represents a group of the following formula (2), or a substituted or unsubstituted 1-naphthyl, 2-naphthyl, indole-2-yl, indole-3-yl, thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl or pyridine-2-yl group wherein the substituents in these groups are those described later with reference R wherein R Q represents a hydrogen atom or a lower alkyl group, D represents a hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, a benzyl group, a pyridylmethyl group, a hydroxy-lower alkyl group, a halogeno-lower alkyl group, an amino-lower alkyl group, a carboxy-lower alkyl group or a group of the following formula (5) or (6): wherein X n represents an integer of 0 to 6 K in the formula (5) represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, azido group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted heteroaryl group, wherein said heteroaryl group is selected from the group consisting of a pyridyl group, a furyl group and a thienyl group and wherein the substituents in these groups are those described with reference R G in the formula (6) represents N or C—H, wherein R E represents a group of the following general formula (7) or a substituted or unsubstituted heteroaryl group, wherein said heteroaryl group is selected from the group consisting of thiophen-3-yl, thiophen-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl, pyridine-2-yl and imidazol-1-yl wherein the substitute is selected from the group consisting of halogens, lower alkyl groups and alkoxyl groups: wherein R X L represents >N-J wherein J represents a hydrogen atom, a lower alkyl group, a carboxy-lower alkyl group or a lower alkyloxycarbonyl-lower alkyl group, Y represents a saturated or unsaturated linear hydrocarbon group having 1 to 6 carbon atoms, which may contain a hetero atom in the group thereof, or a group of the following general formula (8): wherein R m represents an integer of 0 to 5.