Patent ID: 6663608
Filing Date: 2003-12-16
Classification: A61D,A61K

Abstract:
A method of postponing oestrus or treating anoestrus in an animal, said method comprising the steps ofmoulding a progesterone impregnated silicone rubber matrix having a progesterone content in the matrix of 5% or greater by weight, a total progesterone load of at least one gram, a surface area greater than 75 cm2, and at least substantially all of the progesterone in the matrix being less than one millimeter away from a release surface, administering the progesterone impregnated silicone rubber matrix intra vaginally in the animal, maintaining the matrix in position until achieving an ultimate progesterone blood plasma level in the animal of from 2 to about 4 nanograms per milliliter, and removing the device after an insertion period of from 5 to 12 days with a residual load of progesterone in the matrix being less than 65% by weight of an initial progesterone load during the administering step.