Patent ID: 8399505
Filing Date: 2013-03-19
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating a tumor of the cervix or kidney comprising administering to said patient a therapeutically effective and tolerable amount of a compound of formula I or a pharmaceutically acceptable salt thereof in which R1 is hydrogen, R2 is hydrogen, R3 is hydrogen, R4 is hydrogen, R5 is hydrogen, R6 is -T1-Q1, in which T1 is a bond, or 1-2C-alkylene, Q1 is Ar1, in which Ar1 is phenyl, or R61 -substituted phenyl, in which R61 is 1-4C-alkyl, or -T2-N(R611)R612, in which either T2 is a bond, R611 is hydrogen, 1-4C-alkyl, phenyl-1-2C-alkyl, or Har1-1-2C-alkyl, in which Har1 is pyridinyl, benzimidazolyl, benzoxazolyl, benzofuranyl, benzothiophenyl or indolyl, and R612 is hydrogen, 1-4C-alkyl, or hydroxy-2-3C-alkyl, or R611 and R612 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring Het1, in which Het1 is morpholino, or T2 is 1-2C-alkylene, R611 is hydrogen, 1-4C-alkyl, phenyl-1-2C-alkyl, or Har1-1-2C-alkyl, in which Har1 is pyridinyl, benzimidazolyl, benzoxazolyl, benzofuranyl, benzothiophenyl or indolyl, and R612 is hydrogen, 1-4C-alkyl, or hydroxy-2-3C-alkyl, or R611 and R612 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring Het1, in which Het1 is morpholino, and R7 is hydroxyl, or 2-aminophenyl.