Patent ID: 8071770
Filing Date: 2011-12-06
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: B is selected from: where B is linked to A 1 via a carbon atom in B and where B is unsubstituted or substituted with 1-5 substituents each independently selected from R 1 , R 2 , R 3a and R 3b , where R 1 , R 2 , R 3a and R 3b are each independently selected from: (1) —C (2) —C (3) phenyl or heterocycle, wherein heterocycle is selected from: pyridinyl, pyrimidinyl, pyrazinyl, thienyl, pyridazinyl, pyrrolidinyl, azetidinyl, azepanyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, triazolyl, tetrazolyl, azepinyl, benzimidazolyl, benzopyranyl, benzofuryl, benzothiazolyl, benzoxazolyl, chromanyl, furyl, imidazolinyl, indolinyl, indolyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, isoindolinyl, tetrahydroisoquinolinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, pyrazolidinyl, pyrazolyl, pyrrolyl, quinazolinyl, tetrahydrofuryl, thiazolinyl, purinyl, naphthyridinyl, quinoxalinyl, 1,3-dioxolanyl, oxadiazolyl, piperidinyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, and morpholinyl, which phenyl or heterocycle is unsubstituted or substituted with 1-5 substituents each independently selected from: (4) halo, (5) oxo, (6) hydroxy, (7) —O—C (8) —CN, (9) —CO (10) —NR (11) —SR (12) —S(O)R (13) —SO (14) —SO (15) —CONR (16) —OCO (17) —(NR (18) —O(CO)NR (19) —(NR (20) —(CO)—(CO)NR (21) —(CO)—(CO)OR or where R 3a and R 3b and the atom(s) to which they are attached join to form a ring selected from cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl, cyclohexenyl, azetidinyl, pyrrolidinyl, piperidinyl, azepanyl, tetrahydrofuranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, dihydropyranyl, thienyl, dihydrothienyl, tetrahydrothienyl, dihydrothiopyranyl, tetrahydrothiopyranyl, imidazolyl, imidazolinyl, and piperazinyl, which ring is unsubstituted or substituted with 1-5 substituents each independently selected from: (a) —C (b) phenyl or heterocycle, wherein heterocycle is selected from: pyridinyl, pyrimidinyl, pyrazinyl, thienyl, pyridazinyl, pyrrolidinyl, azetidinyl, piperidinyl and morpholinyl, which phenyl or heterocycle is unsubstituted or substituted with 1-3 substituents each independently selected from: (c) halo, (d) —SO (e) hydroxy, (f) —O—C (g) —CN, (h) —COR (i) —NR (j) —CONR (k) —CO (l) —(NR (m) —O(CO)NR (n) —(NR A A where one of A where one or both of A E E where one or both of E E G R R or a pharmaceutically acceptable salt thereof and individual enantiomers and diastereomers thereof.