Patent ID: 6479671
Filing Date: 2002-11-12
Classification: C07D,Y02P

Abstract:
A crystalline salt of the formula (II): wherein * represents the position of an asymmetric carbon atom and that the compound is the (R) or (S) isomer and R1, R 2, R3 and R4 are each independently hydrogen, hydroxy, halogen, optionally substituted alkyl wherein the substituent is halogen, hydroxy, cycloalkyl, carboxy, alkoxycarbonyl, alkoxy, alkoxyalkyloxy, acyl, alkylenedioxy, amino alkylamino, aryl or heterocyclyl optionally substituted alkenyl wherein the substituent is the same as the above,optionally substituted alkynyl wherein the substituent is the same as the above, optionally substituted cycloalkyl wherein the substituent is the same as the above, optionally substituted alkoxy wherein the substituent is the same as the above, optionally substituted alkenyloxy wherein the substituent is the same as the above, optionally substituted alkynyloxy wherein the substituent is the same as the above, optionally substituted cycloalkoxy wherein the substituent is alkyl, alkenyl, halogen, hydroxy, cycloalkyl, carboxy, alkoxycarbonyl, alkoxy, alkoxyalkyloxy, acyl, amino, alkylamino, alkylenedioxy, aryl or heterocyclyl, optionally substituted acyloxy, wherein the substituent is halogen, hydroxy, cycloalkyl, carboxy, alkoxycarbonyl, alkoxy, alkoxyalkyloxy, acyl, alkylenedioxy, amino, alkylamino, aryl or heterocyclyl, or optionally substituted amino wherein the substituent is alkyl, cycloalkyl, aryl or acyl, R5 is alkyl or alkoxyalkyl, A is O or S, Ar is optionally substituted aryl wherein the substituent is alkyl, alkenyl, halogen, hydroxy, cycloalkyl, carboxy, alkoxycarbonyl, alkoxy, alkoxyalkyloxy, acyl, alkylenedioxy, amino, alkylamino, aryl or heterocyclyl, and Q represents an optically active compound.