Patent ID: 7534793
Filing Date: 2009-05-19
Classification: A61P,C07D

Abstract:
1. A compound which is: (R)-2-{4-[(1H-Indol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(Quinolin-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(Benzofuran-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(Quinolin-3-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(3-Chloro-benzothiophen-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(Benzofuran-2-ylmethyl)-amino]-4-hydroxymethyl-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(1H-Benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; 3-({1-[(R)-2-Hydroxy-2-(6-methoxyquinolin-4-yl)-ethyl]-piperidin-4-ylamino}-methyl)-chromen-4-one; (R)-2-{4-[(5-Bromo-1H-indol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxy-quinolin-4-yl)-ethanol; (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[(1-methyl-1H-benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; (R)-2-{4-[(6-Methoxy-benzothiazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxy-quinolin-4-yl)-ethanol; (R)-2-{4-[(4,6-Difluoro-1H-benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-(4-[(4,5-Difluoro-1H-benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(5,6-Difluoro-1H-benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(5-Fluoro-1H-benzimidazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-2-{4-[(4,6-Difluoro-1H-indol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxy-quinolin-4-yl)-ethanol; (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[(1H-pyrrolo[2,3-b]pyridine-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; (R)-1-(6-Methoxy-[1,5]naphthyridin-4-yl)-2-{4-[(quinoxalin-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[(1-H-pyrrolo[3,2-b]pyridin-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; (R)-2-{4-[(Benzothiazol-2-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxy-quinolin-4-yl)-ethanol; 1-{4-[(8-Hydroxy-quinolin-2-ylmethyl)-amino]-piperidin-1-yl}-2-(6-methoxy-quinolin-4-yl)-ethanone; 4-[(4,7-Difluoro-1-H-indol-2-ylmethyl)-amino]-piperidine-1-carboxylic acid (8-fluoro-6-methoxy-quinolin-4-yl)-amide; 4-[(4,6-Difluoro-1H-benzimidazol-2-ylmethyl)-amino]-piperidine-1-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 4-[(1H-Indol-2-ylmethyl)-amino]-piperidine-1-carboxylic acid (6-methoxy-quinolin-4-yl)-amide; 7-Nitro-1H-indole-2-carboxylic acid {1-[(R)-2-hydroxy-2-(6-methoxy-quinolin-4-yl)-ethyl]-piperidin-4-yl}-amide; 4-[(5-Hydroxy-quinoxalin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid (5,8-difluoro-6-methoxy-quinolin-4-yl)-amide; 4-[(8-Hydroxy-quinoxalin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid (5,8-difluoro-6-methoxy-quinolin-4-yl)-amide; (R)-2-{4-[(8-Hydroxy-1-oxo-1,2-dihydro-isoquinolin-3-ylmethyl)-amino]-piperidin-1-yl}-1-(6-methoxyquinolin-4-yl)-ethanol; (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[(thiazolo[5,4-b]pyridin-6-ylmethyl)-amino]-piperidin-1-yl}-ethanol; (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[(1-carboxymethyl-1H-pyrrolo[2,3-b]pyridine-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; or (R)-1-(6-Methoxy-quinolin-4-yl)-2-{4-[carboxymethyl-(1-carboxymethyl-1H-pyrrolo[2,3-b]pyridine-2-ylmethyl)-amino]-piperidin-1-yl}-ethanol; or a pharmaceutically acceptable salt thereof.