Patent ID: 8951998
Filing Date: 2015-02-10
Classification: A61P,C07D,C07K

Abstract:
1. A compound of Formula I or II: or a pharmaceutically acceptable salt or ester thereof, wherein A is absent or selected from —(C═O)—, —S(O) L M is absent or selected from O, S, SO, SO (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C L Z W X and Y taken together with the carbon atoms to which they are attached form a moiety selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclic, or substituted heterocyclic; R (i) hydrogen, halogen, CN, CF (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C R and R′ are each independently selected from the group consisting of: (i) —C (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) hydrogen; deuterium; G is selected from —OH, —NHS(O) R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl; substituted heterocycloalkyl; (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C alternatively, R Z is selected from the groups consisting of: (i) hydrogen; (ii) CN; (iii) N (iv) halogen; (v) —NH—N═CHR (vi) aryl, substituted aryl; (vii) heteroaryl, substituted heteroaryl; (viii) —C (ix) —C (x) —C (xi) —C W is absent, or selected from alkylene, alkenylene, alkynylene, —O—, —S—, —NR m is 1; m′ is 1; and s is 1.