Patent ID: 7674778
Filing Date: 2010-03-09
Classification: A61P,C07H,C12N

Abstract:
1. A single-stranded siRNA or microRNA represented by formula I: wherein X is H, —P(O)(OM) M represents independently for each occurrence an alkali metal or a transition metal with an overall charge of +1; n is 16, 17, 18, 19, 20, 21, 22, 23, or 24; R A Z Z R R R A A A B B R represents independently for each occurrence hydrogen or alkyl; m represents independently for each occurrence 1, 2, 3, 4, 5, 6, 7 or 8; m v represents independently for each occurrence 1, 2, 3, or 4; w represents independently for each occurrence 1, 2, or 3 in accord with the rules of valence; provided that A A and compound C′ is represented by: wherein for C and C′ R R R R p represents independently for each occurrence 1, 2, 3, 4, 5, 6, or 7; and compound D is represented by: and compound D′ is represented by: wherein for D and D′ R R R t represents independently for each occurrence 1, 2, 3, 4, 5, 6, or 7.