Patent ID: 6545011
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt, hydrate, or mixtures thereof, wherein:R1 hydrogen, OH, halogen, amino, nitro; R2 is independently, â€”TP, hydrogen, OH, halogen, amino, nitro, â€”SO2OH or acetylamino; wherein T is one of P is Zâ€”(N(R3R4)), Z or a 5 or 6 membered substituted or unsubstituted aromatic or non-aromatic ring which contains 0, 1, 2 or 3 heteroatoms selected from the group consisting of O, N, S and a combination of two or three of O, N and S; Q is methylene, hydroxymethyl, carbonyl, S, NH, >CHNH2, >Câ€”Oâ€”C(O)(C1-C6 alkyl) or O; and n is 1 or 2; wherein A is carbon or S&boxH;O, X is O, S, N or an N-substituted amino acid; provided that, when R2 is hydrogen, Q is NH, S or O; when R2 is OH, halogen, amino, nitro or acetylamino, n=1 and R1 is hydrogen, then Q is not methylene or carbonyl; when R1 and R2 are both NH2, Q is not methylene; when X is O or S, then Y is absent, when X is N, then Y is hydrogen, C1-C6 straight or branched chain alkyl, optionally substituted alkoxy or alkyl amino, or Y and Z are taken together to form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic aromatic or non-aromatic ring which contains 1, 2 or 3 heteroatoms selected from O, N, S and mixtures combination; Z is hydrogen, a direct bond, a carbonyl, an optionally substituted C1-C5 straight or branched chain alkyl, cycloalkyl, carboxy, optionally substituted C1-C6 ether, aryl or heteroaryl, alkylalkenyl, alkynyl, alkylhalo, straight or branched chain, aryl, cycloalkyl or CH2COOH, provided that when P is Z, Z is not hydrogen and R3 and R4 are independently hydrogen, lower alkyl, lower alkenyl, lower alkanol, heterocycle, heteroaryl, alkoxy, aryloxy, alkylamino, arylamino, CH2COOH, or R3 and R4 taken together form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O, N, S and combinations thereof.