Patent ID: 6448286
Filing Date: 2002-09-10
Classification: A61K,A61P,C07D

Abstract:
A pharmaceutical composition comprising a compound having the formula: and salts and pharmaceutically acceptable esters thereof, wherein:X is selected from the group consisting of methylene, SO, and SO2 wherein methylene may optionally be substituted with hydroxy, lower alkyl, lower alkoxy, amino, and haloalkyl groups; n is 1; R1 is selected from the group consisting of lower alkenyl, lower alkynyl, lower alkoxy, lower thioalkoxy, halogen, nitro, amino, cyano, haloalkyl, carboaryloxy, carboalkylaryloxy, alicyclic hydrocarbon, â€”SO2NR5R6, â€”COR5, â€”SO2R5, alkyl sulfoxide, aryl sulfoxide, alkyl sulfate, and aryl sulfate, wherein all said radicals can be optionally substituted with one or more of the following: hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy,lower thioalkoxy, halogen, nitro, amino, carboxyl, cyano, carboalkoxy, carboaryloxy, carboxyalkylaryloxy, haloalkyl, â€”SO2NR5R6 and â€”SO2R5 wherein all said substitutions may be optionally substituted with one or more of the following: amino, carboxyl, carboalkoxy, carboaryloxy, carboxyalkylaryloxy and lower alkoxy; R2 is selected from the group consisting of hydrogen, lower allyl, lower alkenyl, lower alkynyl, lower alkoxy, lower thioalkoxy, halogen, nitro, amino, cyano, haloalkyl, carboaryloxy, carboalkylaryloxy, alicyclic hydrocarbon, â€”CONR5R6, â€”SO2NR5R6, â€”COR5, â€”SO2R5, alkyl sulfoxide, aryl sulfoxide alkyl sulfate, and aryl sulfate, wherein all said radicals are optionally substituted with one or more of the following: hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower thioalkoxy, halogen, nitro, amino, carboxyl, cyano, carboalkoxy, carboaryloxy, carboxyalkylaryloxy, haloalkyl, â€”SO2NR5R6 and â€”SO2R5, wherein all said substitutions are optionally substituted with one or more of the following: amino, carboxyl, carboalkoxy, carboaryloxy, carboxyalkylaryloxy and lower alkoxy; R3, R4 are independently selected from the group consisting of hydrogen, hydroxy, and alkyloxy; R5 and R6 are independently selected from the group consisting of hydrogen, lower alkyl, and aryl; and together with at least one non-toxic pharmaceutical acceptable carrier.