Patent ID: 6316627
Filing Date: 2001-11-13
Classification: C07C,C07D

Abstract:
A process for preparing a compound of formula (A): ##STR24##whereinAr represents a benzene ring;R is hydrogen or a substituent selected from alkyl, alkoxy, alkylthio, halogen, haloalkyl, haloalkoxy, haloalkylthio, phenyl, phenoxy, benzyloxy, N-substituted or N,N-disubstituted amino groups, nitro, alkoxycarbonyl, cyano, carboxyl and when m>1 the R substituents may be the same or different;R' is a 2-piperidyl or 2-pyridyl radical,n is 1, 2 or 3;m is 0, 1, 2, 3 or 4; where n+m.ltoreq.5; andpharmaceutically acceptable salts thereof, which process comprises the steps of:a) reacting a halobenzoic acid or a salt thereof of the formula [II] ##STR25##whereinAr, R, n and m are as defined above;M is hydrogen or a metal, ammonium or phosphonium cation; andX is Cl, Br or I, and when n>1 the X substituents may be the same or different;with 2,2,2-trifluoroethanol in the presence of a strong base and copper or a copper compound or alloy, if desired followed by acidification to obtain a compound of formula [I] ##STR26##wherein Ar, R, m and n are as defined above, andb) converting the product obtained in step a) above into the compound of formula (A) or a pharmaceutically acceptable salt thereof.