Patent ID: 7429668
Filing Date: 2008-09-30
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula (I): wherein R, R′ and R″ represent, independently of each other, one or more hydrogen, halogen (Cl, F, Br or I), cyano, nitro, linear or branched alkyl of 1 to 6 carbon atoms, linear or branched alkoxy of 1 to 6 carbon atoms, linear or branched alkyl carboxylate of 1 to 6 carbon atoms, trifluoromethyl or trifluoromethoxy; and R′″ represents a linear or branched alkyl or perfluoroalkyl group of 1 to 6 carbon atoms or an aryl group optionally substituted with one or more radicals R″; comprising reacting a compound of formula (II): wherein R and R′ are as defined above and R1 represents a methyl, trifluoromethyl, C 4 F 9 , C 8 F 17 or phenyl optionally substituted with a methyl, bromo or nitro; with a compound of formula (III): wherein R″ and R′″ are as defined above; in an organic solvent optionally in the presence of water, at a temperature in the range of from about 20° C. to about 150° C. in the presence of mineral or organic base and of a phase-transfer agent.