Patent ID: 6716433
Filing Date: 2004-04-06
Classification: A61K,A61P,C07K,Y10S

Abstract:
A recombinant fusion polypeptide, comprising a multivalent immunogenic portion fused to an immunogenic polypeptide carboxy-terminal to the multivalent immunogenic portion, which protects the immunogenicity of the multivalent immunogenic portion, wherein the multivalent immunogenic portion comprises at least two immunogenic amino-terminal polypeptides of Group A streptococcal M protein from at least two different Group A streptococcal serotypes, wherein each of the immunogenic amino-terminal polypeptides is at least 10 amino acids in length, and wherein the immunogenic polypeptide carboxy-terminal to the multivalent immunogenic portion is a reiteration of the immunogenic amino-terminal polypeptide from the amino terminus of the multivalent immunogenic portion.