Patent ID: 8697845
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An antibody molecule which is A monoclonal antibody, or a fragment or antigen binding domain thereof, which binds specifically to a native soluble form of cytotoxic T-lymphocyte antigen 4 (sCTLA-4) and which does not specifically bind to cytotoxic T-lymphocyte antigen 4 (CTLA-4) on the surfaces of lymphocytes, wherein the antibody molecule specifically binds an sCTLA-4 epitope within the amino acid sequence AKEKKPSYNRGLCENAPNRARM (SEQ ID NO: 11) and wherein the antibody molecule comprises: (i) a VH domain comprising an amino acid sequence that is identical to SEQ ID NO: 4 and, (ii) a VL domain comprising an amino acid sequence that is identical to SEQ ID NO: 2.