Patent ID: 8658691
Filing Date: 2014-02-25
Classification: A61K,A61P,C07D

Abstract:
1. A crystalline hydrochloride salt of (S)-3-[(S)-2-methanesulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine; wherein the crystalline hydrochloride salt is selected from: (a) an anhydrous Form I, characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 5.37±0.20, 9.89±0.20, 10.28±0.20, 16.06±0.20, 16.66±0.20, 19.90±0.20, 21.46±0.20, 23.18±0.20, 26.88±0.20, and 27.28±0.20; (b) an anhydrous Form II, characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 7.14±0.20, 9.86±0.20, 11.38±0.20, 14.20±0.20, 15.64±0.20, 18.00±0.20, 21.38±0.20, 22.24±0.20, 30.20±0.20, and 36.36±0.20; and (c) a monohydrate, characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 11.54±0.20, 14.38±0.20, 14.96±0.20, 16.44±0.20, 18.30±0.20, 19.62±0.20, 21.56±0.20, 24.56±0.20, 25.06±0.20, 25.96±0.20, and 26.92±0.20.