Patent ID: 6180739
Filing Date: 2001-01-30
Classification: A61K,C08B,C08F,C09J

Abstract:
A composition of matter comprising.(a) organofunctional monomers that are a mixture of reaction products resulting from a combinatorial synthesis of one or more cyclodextrins selected from the group consisting of alpha-cyclodextrin; beta-cyclodextrin; gamma-cyclodextrin; and hydroxyalkylated cyclodextrinswith a sufficient quantity of one or more reagents selected from the group consisting of methacrylic anhydride; methacrylic acid chloride; acrylic anhydride; acrylic acid chloride; glycidyl methacrylate; glycidyl acrylate; 2-isocyanatoethylmethacrylate; 2-isocyanatoethylacrylate; 2-halo-ethyl methacrylate; 2-halo-ethyl acrylate; 4-vinylbenzylchloride; and 4-vinylbenzylbromide;and with a sufficient quantity of one or more cyclic monoanhydrides selected from the group consisting of cyclic glutaric anhydride; maleic anhydride; itaconic anhydride; succinic anhydride; phthalic anhydride; tetrabromophthalic anhydride; methyl succinic anhydride; diacetyl-1-tartaric anhydride; 2-octen-1-ylsuccinic anhydride; hexahydro-4-methylphthalic anhydride; 1,2-cyclohexanedicarboxylic anhydride; 1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dicarboxylic anhydride; 1-cyclopentene-1,2-dicarboxylic anhydride; 2,2-dimethylglutaric anhydride; 2,2-dimethylsuccinic anhydride; 2,3-dimethylmaleic anhydride: 2-dodecen-1-ylsuccinic anhydride; 3,3-dimethylglutaric anhydride; 3,3-tetramethyleneglutaric anhydride; 3,4,5,6-tetrahydrophthalic anhydride; 3,5-diacetyltetrahydropyran-2,4,6-trione-anhydride; 3-ethyl-3-methylglutaric anhydride; 3-methylglutaric anhydride; bromomaleic anhydride; cis-1,2,3,6-tetrahydrophthalic anhydride; cis-1,2-cyclohexanedicarboxylic anhydride; cis-5-norbornene-endo-2,3-dicarboxylic anhydride; cis-aconitic anhydride; citraconic anhydride; dichloromaleic anhydride; endo-bicyclo(2.2.2)oct-5-ene-2,3-dicarboxylic anhydride; exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride: hexafluoroglutaric anhydride; methyl-5-norbornene-2,3-dicarboxylic anhydride: methylsuccinic anhydride; octadecenylsuccinic anhydride; S-acetylmercaptosuccinic anhydride; tetrapropenylsuccinic anhydride; phenylsuccinic anhydride; 1,2,4-benzenetricarboxylic anhydride; 1,8-naphthalic anhydride; 2,3-diphenylmaleic anhydride; 2-phenylglutaric anhydride; 2-sulfobenzoic acid cyclic anhydride; 3,6-dichlorophthalic anhydride; 3,6-difluorophthalic anhydride; 3-hydroxyphthalic anhydride; 4,5-dichlorophthalic anhydride: 4-bromo-1,8-naphthalic anhydride; 4-methylphthalic anhydride; 5-chloroisatoic anhydride; diphenic anhydride; homophthalic anhydride; isatoic anhydride; N-methylisatoic anhydride; phenylmaleic anhydride; tetrachlorophthalic anhydride; and tetrafluorophthalic anhydride to assure that each molecule in said mixture of reaction products contains no fewer than one covalently attached polymerizable group per molecule and contains no fewer than one covalently attached group containing at least one carboxylic acid group selected from the group consisting of a protonated carboxylic group, a dissociated carboxylate group, salts, amine complexes, esters, and amides thereof;(b) one or more amines selected from the group consisting of ethyl-4-dimethylaminobenzoate: 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU); 4-(dimethylamino)pyridine: hexamethylenetetramine (methenamine); 1,4-diazabicyclo[2.2.2]octane; guinuclidine; 2-quinuclidine carboxylic acid; N,N-dimethyl-p-toluidine: N,N-dimethyl-3,5-dimethylaniline; 4-tert-butyl-N,N-dimethylaniline; N,N-dimethylglycine; N-alkylated imidazoles; triphenylamine: N,N-dimethylaminoethyl methacrylate, N,N-diethylaminoethyl methacrylate; 4-vinylpyridine; 2-vinylpyridine; 1-vinylimidazole; N-vinylformamide; 1-vinyl-2-pyrrolidinone; and 2,6-di-tert-butyl-4-(dimethylamino)methylphenol;(c) one or more low-viscosity monomer(s) selected from the group consisting of 2-hydroxyethyl methacrylate: triethylene glycol dimethacrylate; cyclohexyl methacrylate; benzyl methacrylate; methyl methacrylate: glycerol dimethacrylate; polyethylene glycol 400 dimethacrylate; polyethylene glycol 600 dimethacrylate; polyethylene glycol 400 diacrylate; polyethylene glycol 1,000 dimethacrylate; polypropylene glycol dimethacrylate; triethylene glycol diacrylate; diethylene glycol diacrylate; diethylene glycol dimethacrylate; ethylene glycol diacrylate; ethylene glycol dimethacrylate; water-miscible liquid dimethacrylates and diacrylates; divinyl reaction products of 4,8-bis(hydroxymethyl)tricyclo[5.2.1.0.sup.2,6 ]decane with one or more members selected from the group consisting of methacrylic anhydride, methacryloyl chloride, acryloyl chloride, and acrylic anhydride; the divinyl condensation reaction products of 1,4-dimethylolcyclohexane with one or more members selected from the group consisting of methacrylic anhydride, methacroyl chloride, acrloyl chloride, and acrylic anhydride; styrene; and divinylbenzene;(d) one or more free-radical polymerization initiator(s) selected from the group consisting of camphorguinone (2,3-bornanedione); camphorquinone-10-sulfonic acid; benzoyl peroxide; t-butyl peroxide; per esters; and AIBN (2,2'-azobisisobutyronitrile); and(e) one or more polymerization inhibitor(s) selected from the group consisting of butylated hydroxy toluene (BHT): 3,5-di-tert-butyl-4-hydroxyanisole (2,6-di-tert-butyl-4-methoxyphenol); 2,6-di-tert-butyl-4-(dimethylamino)methylphenol; and 2,5-di-tert-butyl hydroquinone.