Patent ID: 6083941
Filing Date: 2000-07-04
Classification: A61K,A61P

Abstract:
A method for inhibiting N-methyl-D-aspartate glutamate receptor mediated ion-channel activity in an individual in need thereof comprising administering an effective amount of a compound selected from the group consisting of 3.alpha.-hydroxy-16-imino-5.beta.-17-aza-androstane-11-one, 3.alpha.-hydroxy-5.alpha.-pregnane-11,20-dione hemisuccinate, pregnanolone sulfate, pregnanalone hemisuccinate, pregnenolone phosphate, pregnenolone formate, pregnenolone hemioxalate, pregnenolone hemimalonate, pregnenolone hemiglutarate, 20-oxopregn-5-en-3.beta.-yl carboxymethyl ether, 3.alpha.-hydroxypregn-5-en-20-one sulfate, 3-hydroxy-19-norpregna-1,3,5(10)-trien-20-one, 3-hydroxy-19-norpregna-1,3,5(10), 6,8-pentaen-20-one, 17.alpha.-isopregnenolone sulfate, 17-acetoxypregnenolone sulfate, 21-hydroxypregnenolone sulfate, 20.beta.-acetoxy-3.beta.-hydroxypregn-5-ene-sulfate, pregnenolone sulfate 20-ethyleneketal, pregnenolone sulfate 20-carboxymethyloxime, 20-deoxypregnenolone sulfate, 21-acetoxy-17-hydroxypregnenolone sulfate, 17-propyloxypregnenolone sulfate, 17-butyloxypregnenolone sulfate, pyridinium, imidazolium, 6-methylpregnenolone sulfate, 6,16.alpha.-dimethylpregnenolone sulfate, 3.beta.-hydroxy-5.beta.-pregnan-20-one sulfate, 3.beta.-hydroxy-6-methylpregna-5,16-dien-20-one sulfate, 3.beta.-hydroxy-6,16-dimethylpregna-5,16-dien-20-one sulfate, 3.beta.-hydroxypregna-5,16-dien-20-one sulfate, diosgenin sulfate, 3.beta.-hydroxyandrost-5-en-17.beta.-carboxylic acid methyl ester sulfate, 3.alpha.-hydroxy-5.alpha.-pregnan-20-one sulfate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one sulfate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one formate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one hemioxalate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one hemimalonate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one hemisuccinate, 3.alpha.-hydroxy-5.beta.-pregnan-20-one hemiglutarate, estradiol-3-formate, estradiol-3-hemioxalate, estradiol-3-hemimalonate, estradiol-3-hemisuccinate, estradiol-3-hemiglutarate, estradiol-17-methyl ether, estradiol-17-formate, estradiol-17-hemioxalate, estradiol-17-hemimalonate, estradiol-17-hemisuccinate, estradiol-17-hemiglutarate, estradiol 3-methyl ether, 17.beta.-estradiol-3-hemisuccinate, 17-deoxyestrone, 17.beta.-hydroxyestra-1,3,5(10)-trien-3-yl carboxymethyl ether, 11.beta.-OH-pregnanolone sulfate, and androsterone sulfate.