Patent ID: 6683192
Filing Date: 2004-01-27
Classification: A61K,A61P,C07D

Abstract:
compound represented in general formula (X): wherein, as valence and stability permit, Ar represents a substituted or unsubstituted aryl or heteroaryl ring; X is selected from â€”C(&boxH;O)â€”, â€”C(&boxH;S)â€”, â€”S(O2)â€”, â€”S(O)â€”, and a methylene group optionally substituted with 1-2 lower alkyls; Y is absent for each occurrence; Z is absent or represents a substituted or unsubstituted aryl, carbocyclyl, heterocyclyl, or heteroaryl ring, or a lower alkyl, nitro, cyano, or halogen substituent; R represents, independently for each occurrence, H or substituted or unsubstituted lower alkyl; Cyâ€² represents a 3-chloro-benzo(b)thien-2-yl, 3-fluoro-benzo(b)thien-2-yl, or 3-methyl-benzo(b)thien-2-yl, wherein the benzo ring is substituted with from 1-4 substituents selected from halogen, nitro, cyano, methyl, and ethyl; M represents, independently for each occurrence, a substituted or unsubstituted methylene group, or two M taken together represent substituted or unsubstituted ethene or ethyne, wherein some or all occurrences of M in Mj form all or part of a cyclic structure; j represents an integer from 2 to 7; i represents 0 for all occurrences except in the sequence Nâ€”Miâ€”Yâ€”Ar, where i represents 1; and k represents 0.