Patent ID: 7632680
Filing Date: 2009-12-15
Classification: A61K,C12N

Abstract:
1. A method of administering GABAergic neurons into a patient suffering from Parkinson's disease, comprising: (a) obtaining central nervous system (CNS) stem cells; (b) initiating differentiation of the CNS stem cells into differentiated cells comprising GABAergic neurons by culturing them in vitro in differentiation medium comprising fibroblast growth factor 8 (FGF8), glial cell line derived neurotrophic factor (GDNF), all-trans retinoic acid (RA) and dibutyryl cyclic AMP (dBcAMP); (c) analyzing the development of GABAergic neurons in the differentiated cells; and (d) transplanting, 2-4 days after the initiation of differentiation, the CNS stem cells including GABAergic neurons into the central nervous system of the patient, wherein the transplanting is performed before the cells are fully differentiated.