Patent ID: 6500457
Filing Date: 2002-12-31
Classification: A61K

Abstract:
A pulsatile release oral dosage form for treatment of conditions responsive to the administration of an active agent selected from the group consisting of d,l-sotalol, d-sotalol, l-sotalol, amiodarone, and pharmaceutically acceptable acid addition salts thereof, comprising:(a) an immediate release dosage unit comprising a first dose of the active agent that is released immediately following oral administration of the dosage form to a patient said first dose providing an initial burst of active agent followed by a time interval during which little or no active agent is released from the immediate release dosage unit; (b) a delayed release dosage unit comprising a second dose of the active agent and a means for delaying release of the second dose until approximately 6 hours to less than 14 hours following oral administration of the dosage form; and (c) an optional second delayed release dosage unit comprising a third dose of the active agent and a means for delaying release of the third dose until at least 14 hours to approximately 18 hours following oral administration of the dosage form.