Patent ID: 6027941
Filing Date: 2000-02-22
Classification: G01R,Y10T

Abstract:
A method for determining one or more distances in a solid-state sample comprising one or more molecules, said one or more molecules comprising one or more pairs of sites, each said pair of sites comprising a first site and a second site, each said distance being between said first and said second site, said method comprising:a. generating NMR time-domain data from NMR active nuclei, wherein each pair of said one or more pairs of sites has said first site occupied by a first NMR active nucleus and has said second site occupied by a second NMR active nucleus, wherein said first NMR active nucleus is observed in said generating step and said second NMR active nucleus has a chemical shift, and said first and second NMR active nuclei have a dipolar coupling characterized by a dipolar coupling frequency responsive to the distance between said first and second sites, and said time-domain data is responsive along at least one first time dimension to said dipolar coupling of each said one or more pairs and along at least one second time dimension to said chemical shift of said second NMR active nuclei at said second site of said one or more pairs of sites;b. analyzing said NMR time-domain data to obtain spectral-domain data identifying said one or more dipolar coupling frequencies characterizing said dipolar couplings between said first and said second nuclei in said one or more pairs of sites, said analyzing comprising applying a maximum entropy transform to said time-domain data along said first time dimension;c. identifying, for each said dipolar coupling frequency, said one or more chemical shifts of each said second NMR active nucleus with that dipolar coupling frequency; andd. calculating one or more distances between said pairs of sites based on said one or more dipolar coupling frequencies.