Patent ID: 6440943
Filing Date: 2002-08-27
Classification: C07H

Abstract:
An oligomeric compound comprising a plurality of covalently-bound nucleosides; said compound having the formula:5â€²-T1â€”(Nuâ€”Sp)nâ€”(Nuâ€”Lp)mâ€”(NUâ€”Sp)pâ€”Nuâ€”T2-3â€²wherein:T1 and T2 are each, independently, hydroxyl, a protected hydroxyl, a covalent attachment to a solid support, a nucleoside, an oligonucleoside, a nucleotide, an oligonucleotide, a conjugate group or a 5â€² or 3â€² substituent group; each Sp is a chiral Sp phosphorothioate internucleoside linkage; each Lp is, independently, a chiral Rp phosphorothioate internucleoside linkage, a racemic phosphorothioate internucleoside linkage or an internucleoside linkage other than a chiral phosphorothioate internucleoside linkage; each n and m is, independently, from 1 to 100; each p is from 0 to 100; where the sum of n, m and p is from 3 to about 200; each Nu independently, has the formula: â€ƒwherein: Bx is a heterocyclic base moiety; and R1 is H, hydroxyl, a protected hydroxyl, a 2â€²-substituent group or a protected 2â€²-substituent group.