Patent ID: 7700575
Filing Date: 2010-04-20
Classification: A61K,C12N

Abstract:
1. An isolated myocilin-specific ribonucleic acid (RNA), wherein the RNA is a double-stranded molecule with a first strand of RNA that is a ribonucleotide sequence that corresponds to a nucleotide sequence encoding myocilin and a second strand of RNA that is a ribonucleotide sequence that is complementary to the nucleotide sequence encoding myocilin, wherein the first and the second ribonucleotide strands are complementary strands that hybridize to each other to form the double-stranded molecule, wherein the RNA comprises less than 30 bp and has 21 contiguous nucleotides encoded by SEQ ID NOs. 1, 2, 3 or 4 and wherein the double-stranded molecule suppresses accumulation of myocilin in a trabecular meshwork (TM) cell.