Patent ID: 7687682
Filing Date: 2010-03-30
Classification: A01K,A61K,C12N,G01N

Abstract:
1. A method of screening an agent for toxic activity and a pharmacological activity in vivo comprising: administering the agent to a plurality of teleosts in vivo; detecting in vitro or in situ a change in expression of a protein or mRNA in a specific organ or tissue of the teleost responsive to the agent relative to the expression of the protein or mRNA in the specific organ or tissue of a teleost to which the agent has not been administered, the change in expression indicating toxic activity in at least one tissue or organ of the teleost administered the agent; and detecting in vitro or in situ a change in a different teleost administered the agent relative to a control teleost not administered the agent, wherein the change is indicative of the pharmacological activity.