Patent ID: 7879764
Filing Date: 2011-02-01
Classification: B01J,B01L,B82Y,C12Q,C40B,G01N

Abstract:
1. A method of detecting a biochemical analyte comprising: providing a substrate including an array of regions defining a plurality of cells, each of the plurality of cells including a reaction cavity comprising a sensor comprising at least one transistor with a source, a drain, and a gate; and multiple functional binding groups on the gate of said transistor, wherein the array of regions comprises a first gradient of a first functional binding group in a first direction of the array of regions and a second gradient of a second functional binding group in a second direction of the array of regions and wherein the multiple functional binding groups in the plurality of cells are in different ratios and/or densities; wherein a distance between the first binding group and the second binding group corresponds to an inter-molecular distance between binding locations on the biochemical analyte; contacting a sample containing said biochemical analyte onto said substrate, thereby allowing said biochemical analyte to interact with the multiple functional binding groups; applying a voltage between the transistor's source and drain; detecting an electrical parameter in at least one reaction cavity to thereby detect said biochemical analyte.