Patent ID: 6156784
Filing Date: 2000-12-05
Classification: A61K,C07D,Y02A

Abstract:
A compound of the formula (I): ##STR15## wherein: A is selected from the group consisting of alkyl; alkenyl; alkynyl; alkoxy; cycloalkyl; cycloalkenyl; heterocyclyl selected from pyrrolyl and pyrrolinyl each heterocycyl is optionally partially or fully halogenated and optionally substituted with alkyl, hydroxyl, nitro, --COOH, --CO(lower alkoxy), --CO(lower alkyl), amino, alkylamino dialkylamino, alkoxy, --NCOH, --NCO(lower alkyl), --NSO.sub.2 --Ph(halo).sub.0-3, Ph, --O--Ph, naphthyl, --O--naphthyl, pyrrolyl and pyrrolyl subsituted with lower alkyl; and aryl; wherein said cycloalkyl, heterocyclyl or aryl is optionally linked to Q or N via an alkoxy, --O--, amino, lower alkyl, lower alkyl amino, carbonyl, amido, amido alkyl, alkoxycarbonyl, carbonylalkyloxy, cycloalkyl and heterocyclyl linker wherein the heterocyclyl is as hereinabove defined;Q is selected from the group consisting of a bond, >C.dbd.O, >S(O).sub.2 and >C.dbd.S; wherein A and Q optionally form a nitrogen protecting group (NPG);B is selected from the group consisting of H; lower alkyl and a nitrogen-protecting group;G is selected from the group consisting of H or an oxygen-protecting group (OPG);R is CR.sub.1 R.sub.2 wherein R.sub.1 is H, alkyl, or alkoxy and R.sub.2 is OH, alkyl or alkoxy, and wherein R.sub.1 and R.sub.2 may be connected to form a ring of between three and 6 members if R.sub.1 is alkyl or alkyloxy;C is an acidic functionality selected from carboxyl, sulfonyl and the ester derivates thereof wherein C is optionally covalently attached to an OPG and the pharmaceutically acceptable salts thereof.