Patent ID: 6080767
Filing Date: 2000-06-27
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula ##STR315## R.sub.1 and R.sub.2 are hydrogen or taken together are .dbd.NR.sub.9 ; R.sub.3 is hydrogen, --CO.sub.2 R.sub.6, --C(O)R.sub.6, --CONR.sub.6 R.sub.6, --CH.sub.2 OR.sub.7 or --CH.sub.2 SR.sub.7 ;R.sub.4 is hydrogen, alkyl, Q-alkyl, thiocycloalkyl, or cycloalkylalkyl, or a group of formula ##STR316## R.sub.5 is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, or optionally substituted aralknyl;R.sub.6 is hydrogen or lower alkyl;R.sub.7 is hydrogen, lower alkyl, Ar(lower alkyl), lower acyl, aroyl or heteroaroyl;R.sub.8 is hydrogen or lower alkyl;R.sub.9 is hydrogen, R.sub.10 O.sub.2 C--, R.sub.10 O--, HO--, cyano, R.sub.10 CO--, HCO--, lower alkyl, nitro, or Y.sup.1a Y.sup.2a N--;R.sub.10 is optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted heteroaralkyl;Y.sup.1a and Y.sup.2a are independently hydrogen or alkyl;A and B are hydrogen or taken together are a bond;Q is R.sub.7 O-- or R.sub.7 S-- or Y.sup.1 Y.sup.2 N--;Ar is optionally substituted aryl or optionally substituted heteroaryl; andn is 0, 1 or 2; ora pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof, a solvate thereof, or prodrug thereof.