Patent ID: 8618146
Filing Date: 2013-12-31
Classification: A61K,A61P,C07D

Abstract:
1. A process for preparing a formulation of an epothilone compound having formula A, where R is hydrogen, or an alkyl, substituted alkyl, aryl, substituted aryl, or heterocyclic group, including any salts and any stereoisomers of the compounds or salts, comprising: a) dissolving the epothilone compound in a mixture of at least 20% by volume tertiary-butanol and acetone or acetonitrile; b) drying the solution at about −80° C. to about 40° C. under vacuum from about 5 millitorr to about 250 millitorr, to form a primary lyophilized product; and c) drying the primary lyophilized product at about 10° C. to about 30° C. under vacuum from about 5 millitorr to about 300 millitorr, to provide a lyophilized product of the epothilone compound.