Patent ID: 6335339
Filing Date: 2002-01-01
Classification: A61K

Abstract:
A method of preventing or treating hepatitis B virus infection in a patient in need of such treatment, said method comprising administering a compound of the formula IA: or IB: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclic, fused or polycyclic ring and aryloxy; wherein said alkyl, alkenyl or alkynyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkyl, nitro, trihalomethyl, aryl, aryloxy, alkoxy, amino, carbonyl, carboxyl, ester, amide, primary, secondary or tertiary amines, cyano, cycloalkyl, alkenyl, cycloalkenyl or alkynyl, and wherein said aryl, aryloxy, heteroaryl, non-aromatic heterocyclic, or fused or polycyclic ring is optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, alkyl, nitro, trihalomethyl, aryl, aryloxy, alkoxy, amino, carbonyl, carboxyl, ester, amide, primary, secondary or tertiary amines, cyano, cycloalkyl, alkenyl, cycloalkenyl and alkynyl; or wherein R1 and R2 together, R3 and R4 together, or R5 and R6 together, optionally form a cycloalkyl or cycloalkenyl ring system, or an unfused polycyclic or monocyclic, non-aromatic heterocyclic or heteroaryl ring system, wherein said ring systems are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkyl, nitro, trihalomethyl, aryl, aryloxy, alkoxy, amino, carbonyl, carboxyl, ester, amide, primary, secondary or tertiary amines, cyano, cycloalkyl, alkenyl, cycloalkenyl and alkynyl; or wherein R7 and R8 together optionally form a cycloalkyl, cycloalkenyl, non-aromatic heterocyclic, or fused or polycyclic ring wherein said cycloalkyl, cycloalkenyl, non-aromatic heterocyclic, or fused or polycyclic ring are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkyl, nitro, trihalomethyl, aryl, aryloxy, alkoxy, amino, carbonyl, carboxyl, ester, amide, primary, secondary or tertiary amines, cyano, cycloalkyl, alkenyl and alkynyl, with the proviso that when R7 and R8 together form a non-fused polycyclic ring, the moiety of the non-fused polycyclic ring that binds with N is non-aromatic, and pharmaceutically acceptable salts thereof,and a pharmaceutically acceptable carrier or diluent, wherein said compound is administered in an amount and for a time sufficient to inhibit viral replication.