Patent ID: 8877238
Filing Date: 2014-11-04
Classification: A61K,A61P

Abstract:
1. A process for the production of granules containing as an active ingredient imatinib monomethanesulfonate in the alpha crystalline form, said process comprising: dry granulating an active ingredient consisting of imatinib monomethanesulfonate in the alpha crystalline form and at least one compound acting as a filler-binder to obtain a flowable mixture starting material; and pressing the starting material to produce the granules; wherein at least 80% the active ingredient has a mean particle size distribution in the range from 0.01 mm to 1.0 mm; wherein said dry-granulation is carried out in a compactor at pressures in the range from 10 to 300 bar at room temperature; and wherein the resulting granules contain the active ingredient in a proportion of 25% by weight to 80% by weight, based on the total weight of the granules.