Patent ID: 7537894
Filing Date: 2009-05-26
Classification: C12Q

Abstract:
1. A method of assessing risk of adenocarcinoma in a mammal with Barrett's esophagus comprising: (a) determining the ratio of the expression of GATA6 and SPRR3 in esophageal cells from the mammal; and (b) comparing the ratio of step (a) to the ratio of expression of GATA6 and SPRR3 in a reference selected from the group consisting of normal esophageal epithelium obtained from the mammal at the same or different time, cells characteristic of Barrett's esophagus obtained from the mammal at a different time, and a normal range established using normal esophageal epithelium obtained from a population of individuals, an increase in the ratio of step (a) relative to the ratio of the reference being indicative of increased risk of adenocarcinoma.