Patent ID: 8101159
Filing Date: 2012-01-24
Classification: A61K,A61P,C12N,G01N

Abstract:
1. A method of identifying a compound which is able to preferentially target suppressed micrometastatic cancer cells over non-suppressed micrometastatic cancer cells, comprising: providing labeled cancer cells comprising a fluorescent label; providing a malignant phenotype-suppressing matrix; injecting, in a test animal, a first portion of the labeled cancer cells and the malignant phenotype suppressing matrix thereby producing an injected test animal having a suppressed population of malignant phenotype cancer cells; injecting, in a control animal, a second portion of the labeled cancer cells without the malignant phenotype suppressing matrix thereby producing an injected control animal having a non-suppressed population of malignant phenotype cancer cells; treating the injected test animal and injected control animal with a test compound and incubating said labeled cancer cells within the injected test animal and injected control animal; and measuring the injected test animal and injected control animal for fluorescence emitted from the labeled cancer cells therein, and wherein when the fluorescence measured from the injected control animal exceeds the fluorescence measured from the injected test animal, the test compound is shown to preferentially target suppressed micrometastatic cancer cells over non-suppressed micrometastatic cancer cells.