Patent ID: 6512118
Filing Date: 2003-01-28
Classification: A61K,A61P,C08B

Abstract:
A compound comprising camptothecin of formula (I): wherein any two of the substituent variables R1, R2, R3, R4 and R5 that are adjacent to one another combine to form an alkylene group, and the remaining three substituent variables among R1, R2, R3, R4 and R5 are independently selected from the group consisting of a hydrogen atom, an alkyl group or a halogen atom, and wherein one of the carbon atoms of said alkylene group is substituted by a group of the formula Xn-AlkmR6, and whereinone or two methylene groups of the alkylene group may optionally be replaced by â€”Oâ€”, â€”Sâ€” or â€”NHâ€”; and wherein X is â€”Oâ€” or â€”NHâ€”, Alk is an alkylene group, R6 is â€”NHR7, â€”OR7, or a moiety of the formula: R7 is an amino acid or a peptide, m and n are both 0 or 1, or m is 1 and n is 0; or a salt thereof.