Patent ID: 6607754
Filing Date: 2003-08-19
Classification: A61K,Y10S

Abstract:
A method for manufacturing by dry granulation a tablet for the delivery of the active ingredient of St. John's Wort, said tablet comprising by weight of the tablet:40 to 75% by weight St. John's Wort extract, 1.0-5.0% by weight binder, 8-18% by weight dissolution regulator, up to 30% by weight filler, 0.2 to 5.0% by weight glidant as a final proportion of glidant, and 0.5 to 2.5% by weight lubricant as a final proportion of lubricant; said method comprising the steps of: a) mixing components comprising: 40 to 75% by weight St. John's Wort extract, 1.0-5.0% by weight binder, 8-18% by weight dissolution regulator, up to 30% by weight filler, and less than at least one of the final proportion of glidant and the final proportion of lubricant of 0.2 to 5.0% by weight glidant, and 0.5 to 2.5% by weight lubricant to form a slug, b) breaking the slug down into particulates which can be subsequently compressed into a tablet, c) adding sufficient glidant and/or lubricant to form a composition with final proportions of both glidant and lubricant of 0.2 to 5.0% by weight glidant, and 0.5 to 2.5% by weight lubricant, and d) compressing the composition to form a tablet.