Patent ID: 6759409
Filing Date: 2004-07-06
Classification: A61P,C07D

Abstract:
A compound of formula (I), or an enantiomer or diastereoisomer thereof: wherein: A is a 5- or 6-membered carbocyclic ring; X is H and W is OH; or X and W together form a carbonyl group or an epoxide; R1 is H; or one or two substituents independently selected from the group consisting of: hydroxy; halo; lower alkyl; lower alkoxy; lower thioalkyl; haloalkyl (e.g. trifluoromethyl); or â€”C(O)R2 wherein R2 is lower alkyl, aryloxy or benzyloxy; Y is phenyl optionally mono- or di-substituted with R5 or C(O)R6, wherein R5 is lower alkyl, lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile or trifluoromethyl, and R6 is lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy or trifluoromethyl; said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring; or Y is ethylene-phenyl, said ethylene moiety being optionally mono-substituted with lower alkyl, wherein said phenyl ring is optionally mono- or di-substituted with R5 or C(O)R6, wherein R5 and R6 are as defined above; said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring; R3 is selected from the group consisting of: aryl, mono- or di-substituted with: morphiline, said morpholine optionally mono- or di-substituted with lower alkyl, lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile, trifluoromethyl, C(O)R6 wherein R6 is as defined above; and R4 is a carboxylic acid, a salt or an ester thereof.