Patent ID: 8975286
Filing Date: 2015-03-10
Classification: A61K,A61P,C07D

Abstract:
1. A compound according to Formula A or a pharmaceutically acceptable salt thereof, wherein: W is Cl, Br, CN or CF R each R A is selected from phenyl, naphthyl or heteroaryl, any of which is optionally substituted with up to 4 substituents selected from R each R each X is independently selected from the group consisting of: H, C each k is independently 0, 1 or 2; each R is independently selected from the group consisting of: H and C each R each R heteroaryl at each occurrence independently means a 5- or 6-membered monocyclic aromatic or 9- or 10-membered bicyclic aromatic, wherein at least one atom in the aromatic is selected from N,N-oxide, O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N,N-oxide, O and S, the sulfur optionally oxidized to sulfone or sulfoxide; and heterocycle at each occurrence independently means a 4- to 7-membered monocyclic non-aromatic ring, an 8- to 11-membered bi-cyclic, including spiro-cyclic, non- or partially-aromatic ring or a 12- to 20-membered tri-cyclic, including spiro-cyclic portions, non- or partially-aromatic ring, each optionally substituted with 1 to 2 oxo groups, wherein at least one atom is selected from N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide.