Patent ID: 7700748
Filing Date: 2010-04-20
Classification: A01K,A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule selected from the group consisting of: (a) a nucleic acid molecule encoding a human polypeptide having the sequence of SEQ ID NO 2, (b) a nucleic acid molecule encoding a human polypeptide having the amino acid sequence of amino acid position 405 to 594 in SEQ ID NO 2, (c) a nucleic acid molecule encoding a human polypeptide consisting of the amino acid sequence of SEQ ID NO 4, (d) a nucleic acid molecule having the nucleotide sequence of SEQ ID NO 1 or 3, and (e) a nucleic acid molecule consisting of the 85 bp nucleotide sequence of position 1253 to 1337 in SEQ ID NO 1, (f) a modified SEQ ID NO: 1 having a mutation selected from the group consisting of deletion of 2 nucleotides, positions 31-32; insertion of a G, position 107; substitution of a C by an A, position 108; deletion of 5 nucleotides, positions 157-161; insertion of an A, position 423; deletion of 4 nucleotides, positions 554+556−558; deletion of the 5th nucleotide (G) in the splice-site consensus in intron 5 (5′ end of intron); deletion of 4 nucleotides, positions 842-845; deletion of 3 nucleotides, positions 1179-1181; deletion of a T, position 1355; deletion of 4 nucleotides, positions 1470-1473; substitution of a C by a G, position 1547; and deletion of GT, positions 1711-1712, wherein numbering of said mutations refers to the nucleotide numbering as used in SEQ ID NO: 1, where +1 is the A of the ATG codon at positions 39 to 41, and (g) a nucleic acid molecule comprising the nucleotide sequence set forth by SEQ ID NO: 143 with a deletion of the TA at position 3800-3801 and the full length complement thereof.