Patent ID: 8329219
Filing Date: 2012-12-11
Classification: A61K,A61L,A61P,B29C

Abstract:
1. A method for forming an extracellular matrix (ECM) material comprising: a. providing an ECM composition containing ECM particles, the ECM particles including a first population of ECM particles and a second population of ECM particles, the first and second populations of ECM particles having different respective abilities to migrate through a fluid medium, wherein the first population comprises expanded ECM particles and the second population comprises non-expanded ECM particles; b. forming a flowable ECM composition including the ECM particles and the fluid medium; c. subjecting the flowable ECM composition to a centrifugal force in a mold for a period of time sufficient to distribute the first and second populations of ECM particles in the mold according to their respective abilities to migrate through the fluid medium; and d. drying the ECM composition to form a dried ECM material having a density gradient extending from a less dense region to a more dense region.