Patent ID: 8951523
Filing Date: 2015-02-10
Classification: A61K,C07K,C12Q

Abstract:
1. A method of reducing cholesterol level or maintaining previously reduced cholesterol level in a human in need thereof comprising a. selecting a human comprising a nucleotide sequence encoding a proprotein convertase subtilisin/kexin type 9 (PSCK9) that comprises a C-terminal domain comprising a mutation I474V in SEQ ID NO: 1; and b. administering to said human an antibody or antibody fragment that specifically binds a PCSK9 amino acid sequence encoded by said nucleotide sequence comprised by the human, wherein the antibody comprises a VH domain derived from the recombination of a human VH gene segment, a human D gene segment, and a human JH segment, the human VH gene segment encoding the framework 1 of SEQ ID NO: 40; and wherein said human comprises a VH gene segment encoding the framework 1 of SEQ ID NO: 40.