Patent ID: 8268310
Filing Date: 2012-09-18
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An isolated anti-Factor D antibody, or a binding fragment thereof, wherein said antibody or said binding fragment comprises the Complementarity Determining Regions (CDRs) of antibody 20D12 light and heavy chain variable domains (SEQ ID NOS: 1 and 2, respectively), and wherein the light chain CDR1 sequence comprises amino acid residues 24-34, the light chain CDR2 sequence comprises amino acid residues 50-56, and the light chain CDR3 sequence comprises amino acid residues 89-97 of SEQ ID NO: 1, and the heavy chain CDR1 sequence comprises amino acid residues 31-35, the heavy chain CDR2 sequence comprises amino acid residues 50-65, and the heavy chain CDR3 sequence comprises amino acid residues 95-102 of SEQ ID NO: 2.