Patent ID: 6225117
Filing Date: 2001-05-01
Classification: A61K,A61P,C07K

Abstract:
An antibody to the human IL-12 p75 heterodimer, said heterodimer consisting a p35 subunit and a p40 subunit, wherein said antibody(a) immunologically reacts with an epitope presented by the p75 heterodimer of human IL-12, but is not immunologically reactive with any epitope presented by said p40 subunit; and(b) is produced from a hybridoma cell line obtained from a mouse which is deficient in the gene encoding said p35 subunit or the p40 subunit of IL-12, said hybridoma cell line being selected from the group consisting of ATCC designation HB-12446, HB-12447, HB-12448, and HB-12449, or a humanized antibody, thereof.