Patent ID: 6780878
Filing Date: 2004-08-24
Classification: A61P,C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein:A3, A4, A5 and A6, together with the two carbons to which they are attached, complete a substituted heteroaromatic ring in which one of A3, A4, A5 and A6 is N, and each of the others is CR3, CR4, CR5 or CR6, respectively; each of R3, R4, R5 and R6 is independently hydrogen or methyl; L1 is â€”NHâ€”COâ€”, â€”COâ€”NHâ€” or â€”CH2â€”NHâ€” such that â€”L1â€”Q1 is â€”NHâ€”COâ€”Q1 â€”COâ€”NHâ€”Q1 or â€”CH2â€”NHâ€”Q1; Q1 is 2-furanyl, 2-thienyl, 6-indolyl, 6-indolinyl, or 6-indazolyl, in which the 2-furanyl or 2-thienyl may bear a chloro or methyl substituent at the 5-position; 6-indolyl or 6-indazolyl may bear a chloro or methyl substituent at the 3-position; and R2 is â€”NHâ€”CH2â€”Q2 in which Q2 is Q2A wherein Q2A , showing the â€”CH2â€” to which it is attached, is â€ƒin which R2A is 4-pyridinyl, which is unsubstituted or bears a substituent Rv at the 2- or 3-position, wherein Rv is methyl, hydroxymethyl, cyano, carbamoyl, thiocarbamoyl, or N-hydroxyamidino.