Patent ID: 8221720
Filing Date: 2012-07-17
Classification: C07B

Abstract:
1. A process for purifying a radiolabelled product comprising the steps of: (i) reacting a precursor with a radioisotope or radiolabeling agent to form a solution-phase radiosynthesis reaction mixture comprising a radiolabelled product and excess precursor; (ii) contacting said solution-phase radiosynthesis reaction mixture with a solid-support bound scavenger group of formula (IV): wherein: Z is a scavenger group selected from the group consisting of: isocyanate, isothiocyanate, thiol, hydrazine, hydrazide, aminooxy, 1,3-dipole, aldehyde, ketone, —NH SP is a solid support; wherein said excess precursor forms a covalent bond with said solid support bound scavenger group of formula (IV); and (iii) separating said radiolabelled product in the solution-phase; and wherein: said excess precursor is of formula (I) and said radiolabelled product is of formula (III): wherein XY of Formula (I) is either a leaving group capable of reacting with said radioisotope or said radiolabeling agent of Formula (II): and is a mesyl sulphonate ester, tosyl sulphonate ester, nosyl sulphonate ester, or a trimethylammonium salt; or a functional group which can react site-specifically with a moiety on said radiolabeling agent of Formula (II) and is an aldehyde, ketone, aminooxy, hydrazide, hydrazine, alpha-haloacetyl, or thiol.