Patent ID: 7504232
Filing Date: 2009-03-17
Classification: A61P,C07K,G01N

Abstract:
1. A method for identifying a product which is capable of disrupting an interaction between amino acids 162 to 168 of human osteopontin (OPN) and an α4 integrin, which method comprises: (i) providing, as a first component, a polypeptide which comprises the amino acid sequence selected from the group consisting of: SVVYGLR (SEQ ID NO: 4) and RADSVVYGLR (SEQ ID NO: 19); (ii) providing, as a second component, an α4 integrin; (iii) contacting the two components under conditions that would permit the two components to interact and determining the degree of interaction between the two components (iv) contacting the two components with a test product under conditions that would permit the two components to interact in the absence of the test product and determining the degree of interaction between the two components; and (v) determining whether the test product is capable of disrupting the interaction between the first and second components by comparing the degrees of interaction found in (iii) and (iv).