Patent ID: 7563455
Filing Date: 2009-07-21
Classification: A61K,A61L,A61P

Abstract:
1. An osteogenic sponge composition comprising: a highly mineralized sponge implant device, said device being three-dimensionally stable but flexible, said device exhibiting sufficient flexibility to be rolled up when hydrated, said device consisting essentially of a resorbable sponge matrix formed of lyophilized collagen and having particulate biocompatible mineral embedded within said matrix, said device comprised 1% to 3% by weight of the lyophilized collagen and 97% to 99% by weight of the particulate biocompatible mineral, said resorbable sponge matrix having been prepared by a process comprising freeze-drying a slurry including the collagen and particulate biocompatible mineral; and an osteogenic factor effective to stimulate both osteoblasts and osteoclasts when administered to a human, and wherein said osteogenic factor is incorporated into said sponge implant device in an amount to stimulate the osteoclasts to cause an increase in the rate of resorption of said resorbable sponge matrix when said sponge implant device is implanted in a human; and wherein said particulate biocompatible mineral is resorbed more slowly than said resorbable sponge matrix when said sponge implant device is implanted in a human and thereby provides a scaffold for bone ingrowth that remains after said resorbable sponge matrix is resorbed.