Patent ID: 8476454
Filing Date: 2013-07-02
Classification: A61K,A61P,C07D

Abstract:
1. A pharmaceutical composition comprising an effective amount of a compound having indoleamine 2,3 dioxygenase (IDO) inhibitory activity and a pharmaceutically acceptable carrier medium, said compound being of formula (I): wherein R 1 is H or lower alkyl; R 2 is H; R 3 is wherein R A is selected from the group consisting of (C 3 -C 6 )alkenyl, substituted or unsubstituted aralkyl and substituted or unsubstituted cycloalkyl, and R B is selected from the group consisting of H, (C 1 -C 6 ) alkyl, (C 3 -C 6 ) alkenyl, substituted or unsubstituted aralkyl and substituted or unsubstituted cycloalkyl, said substituted aralkyl and substituted cycloalyl having one or two substituents selected from the group of halo, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkythio, hydroxyl, carbonyl, epoxy, —C(═O)—OR, —OC(═O)—R, amino, —NHC(═O)—R, —NHCONH 2 , —NHCONHR or thiol wherein R represents hydrogen or (C 1 -C 4 )alkyl; X, Y, and Z may be the same or different and are selected from the group consisting of H, halogen, NO 2 , and hydrocarbyl; with the proviso that formula (I) does not include 3-(N-allyl-thiohydantoin)-indole.