Patent ID: 7399901
Filing Date: 2008-07-15
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A mouse whose genome comprises a mutant LAT gene encoding a mutant mouse LAT protein, wherein the amino acid sequence of said mutant mouse LAT protein comprises a single mutation of a tyrosine located at position 136 of the wild-type mouse LAT protein sequence, wherein the mutation is not a composite mutation of the tyrosine residue at positions 175, 195 and 235 of said wild-type mouse LAT protein sequence, wherein the single mutation of the tyrosine located at position 136 consists of a replacement with a residue preventing the association with SH2 domain of proteins, wherein said mutant LAT gene replaces the endogenous wild-type LAT gene such that the mutant LAT gene is under the control of the regulatory regions of the endogenous LAT gene, and wherein the mouse is homozygous for said mutant mouse LAT gene, and wherein the mouse has a phenotype of exaggerated TH2 cell differentiation.