Patent ID: 6596850
Filing Date: 2003-07-22
Classification: A61K,C07K

Abstract:
A high affinity LM609 grafted antibody exhibiting selective binding affinity to &agr;v&bgr;3, or a functional fragment thereof, comprising one or more CDRs having at least one amino acid substitution in one or more CDRs of a LM609 grafted heavy chain variable region polypeptide referenced as SEQ ID NO:6 or a LM609 grafted light chain variable region polypeptide referenced as SEQ ID NO:8, said antibody or functional fragment thereof having integrin &agr;v&bgr;3 binding activity, integrin &agr;v&bgr;3 binding specificity or integrin &agr;v&bgr;3-inhibitory activity, wherein the &agr;v&bgr;3 binding affinity of said high affinity LM609 grafted antibody is higher affinity relative to parental LM609 grafted antibody.