Patent ID: 7993627
Filing Date: 2011-08-09
Classification: A61K,C07K,G01N

Abstract:
1. A method for determining a compound is a compound that inhibits production of Aβ(42) and Aβ(40) separately: obtaining control values which are characteristic of the level of Aβ42 peptide and total Aβ or Aβ40 peptide in a sample from a non-human animal used as a model of Alzheimer's disease; administering the compound to the non-human animal used as a model of Alzheimer's disease; measuring an amount of Aβ42 peptide in a sample from the non-human animal administered the compound; and measuring an amount of total Aβ or Aβ40 peptide in a sample from the non-human animal administered the compound; wherein the measured amounts in comparison with the control values indicate differential inhibition of Aβ (42) and Aβ (40)thus indicating the compound is a compound that inhibits production of Aβ(42) and Aβ(40) separately.