Patent ID: 8460666
Filing Date: 2013-06-11
Classification: A61K,A61P,C07K

Abstract:
1. An isolated human monoclonal antibody having opsonic phagocytic killing activity against at least two different Staphylococcus species and against at least three different strains of Staphylococcus aureus , wherein the antibody is selected from the group consisting of: i) an antibody with a heavy chain comprising the variable region of SEQ ID NO:30 and a light chain comprising the variable region of SEQ ID NO:36; ii) an antibody with a heavy chain comprising the variable region of SEQ ID NO:117 and a light chain comprising the variable region of SEQ ID NO:177; iii) an antibody with a heavy chain comprising the variable region of SEQ ID NO:119 and a light chain comprising the variable region of SEQ ID NO:179; iv) an antibody with a heavy chain comprising the variable region of SEQ ID NO:121 and a light chain comprising the variable region of SEQ ID NO:181; and v) an antibody with a heavy chain comprising the variable region of SEQ ID NO:155 and a light chain comprising the variable region of SEQ ID NO:215.