Patent ID: 6663901
Filing Date: 2003-12-16
Classification: A61K,A61P

Abstract:
A process for preparing pellets, each of said pellets comprisinga central, rounded or spherical core having a diameter from about 710 to about 1180 &mgr;m (16-25 mesh); a coating film of a water-soluble polymer and an antifungal agent, and a seal-coating polymer layer, wherein the process comprises a) coating sugar cores by spraying them with a solution of an antifungal agent and a water-soluble polymer in an organic solvent comprising methylene chloride and an alcohol in a fluidized-bed granulator equipped with a bottom spray insert; b) drying the resulting coated cores in vacuo by irradiating said cores with microwave or radiofrequency radiation; and c) seal-coating the dried cores by spraying them with a solution of a seal-coating polymer in an organic solvent comprising methylene chloride and an alcohol in a fluidized-bed granulator equipped with a bottom spray insert, wherein said pellets have a residual concentration of dichloromethane of less than 600 ppm.