Patent ID: 7348148
Filing Date: 2008-03-25
Classification: A61P,C07B,C12Q

Abstract:
1. A process of modulating the expression of a gene in an organism, the process comprising administering to said organism a compound having the general formula: wherein: m and n are each independently an integer; m ≠n; m ≠n−1; d is an integer which equals to or greater than 0; f is an integer greater than 0; L is a linker chain; each of Bm, Bn−1 and Bn is a chemical functionality group independently selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group; each of Ym, Yn−1 and Yn is a first linker group; each of Xm, Xn−1 and Xn is a second linker group; Cm, Cn−1 and Cn are chiral carbon atoms; Q is a backbone bearing said Cm, Cn−1 and Cn chiral carbon atoms; and [K] and [I] are optional first and second exoconjugates, such that said compound binds in a sequence specific manner DNA or RNA deriving from said gene, thereby modulating the expression of the gene in the organism.