Patent ID: 6864054
Filing Date: 2005-03-08
Classification: A61K,A61P,C07K

Abstract:
1. A method for determining whether a compound is capable of inhibiting an interaction between a first polypeptide and a second polypeptide said method comprising: (a) (i) incubating said first polypeptide with said second polypeptide in vitro under conditions which allow the first polypeptide to bind to the second polypeptide to form a complex; and bringing the complex thus formed into contact with a candidate compound; or (b) determining if said candidate compound inhibits binding of the first polypeptide to the second polypeptide; wherein said first polypeptide comprises a Transcriptional Adaptor Motif (TRAM) sequence of any one of the sequences shown in SEQ ID NO: 3 to 9 and said second polypeptide is a human papillomavirus (HPV) polypeptide E6 of HPV-16 or HPV-18 comprising a sequence which binds to a said TRAM sequence.