Patent ID: 8568745
Filing Date: 2013-10-29
Classification: A61K,C12N

Abstract:
1. A process for producing a drug delivery carrier that includes a water-soluble drug double-coated with two types of inner and outer surfactants 1 and 2, the process comprising the steps of: 1) mixing and agitating a water-soluble drug-containing aqueous phase with an oily phase containing the surfactant 1 to form a W/O emulsion in which the water-soluble drug-containing aqueous phase is dispersed in the oily phase; 2) removing the inner aqueous phase from the W/O emulsion to form a S/O in which the water-soluble drug coated with the surfactant 1 is dispersed in the oily phase; 3) mixing and agitating the S/O with an aqueous phase containing the surfactant 2 to form a S/O/W emulsion in which the S/O is dispersed in the aqueous phase; and 4) removing the inner oily phase from the S/O/W emulsion to form a S/W in which the water-soluble drug coated with the surfactant 1 and the surfactant 2 is dispersed in the aqueous phase, wherein the inner surfactant 1 is at least one member selected from the group consisting of: sucrose erucate ester and sucrose laurate ester; and the outer surfactant 2 is at least one member selected from the group consisting of: PC, sucrose laurate ester L-1695, PEG (2K)-DSPE, PEG(5K)-DSPE, PEG(comb)-DSPE, polysorbate 80, sodium dodecyl sulfate, and glycerin fatty acid ester.