Patent ID: 6214545
Filing Date: 2001-04-10
Classification: C12Q

Abstract:
A method, comprising:a) providing:i) one or more copies of a target DNA comprising a folded structure comprising one or more double stranded regions and one or more single stranded regions; andii) a plurality of different oligonucleotide probes complementary to at least a portion of said target DNA;b) mixing said one or more copies of target DNA and said plurality of oligonucleotide probes under conditions such that at least two of said probes hybridize to at least one copy of said target DNA to form probe/folded target complexes;c) detecting said probe/folded target complexes; andd) generating a fingerprint of said folded structure, wherein said generating comprises measuring the level of complex formation between said target nucleic acid and individual members of said plurality of oligonucleotide probes.