Patent ID: 7531573
Filing Date: 2009-05-12
Classification: A61K,A61P,C07C,C07D,C07F

Abstract:
1. A method for inhibiting unwanted non-malignant lymphoproliferation associated with an inflammatory disease, wherein the inflammatory disease is diarrhea; autoimmune disease; proliferative glomerulonephritis; lupus erythematosus; scleroderma; temporal arteritis; thromboangiitis obliterans; mucocutaneous lymph node syndrome; asthma; host versus graft; or inflammatory bowel disease; and wherein said method comprising the step of contacting a cell the proliferation of which contributes to inflammation in situ with an effective amount of a compound having the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein: n is 0, 1, 2, 3 or 4; X is absent, (C Y is C, N, P, Si or Ge; R Ar Ar Ar each R is independently selected from the group consisting of —H, (C the aryl substituents are each independently selected from the group consisting of -halo, trihalomethyl, —R, —R′, —OR′, —SR′, NR′ the alkyl, alkenyl and alkynyl substituents are each independently selected from the group consisting of -halo, —R′, —OR′, —SR′, NR′ each R′ is independently selected from the group consisting of —H, (C wherein said administration is selected from the group consisting of oral, parenteral, intravenous, subcutaneous, transdermal and transmucosal for a living human.