Patent ID: 8153365
Filing Date: 2012-04-10
Classification: A61P,C07H

Abstract:
1. A method for using an oligomer to isolate, purify, amplify, detect, identify, quantify or capture a natural or synthetic nucleic acid, the oligomer being modified with at least one Locked Nucleic Acid (LNA), the method comprising the step of contacting LNA-modified oligomer with the nucleic acid under conditions sufficient to form a binding complex to isolate, purify, amplify, detect, identify, quantify or capture the nucleic acid, wherein the LNA is represented by the following general formula I: wherein X is selected from —O—; B is selected from hydrogen, hydroxy, optionally substituted C P designates a radical position for an internucleoside linkage to a succeeding monomer or a 5′-terminal group, optionally including the substituent R one of the substituents R the substituents R each of the substituents R and basic salts and acid addition salts thereof, wherein a natural or synthetic nucleic acid is isolated, purified, amplified, detected, identified, quantified, or captured using the oligomer.