Patent ID: 6482845
Filing Date: 2002-11-19
Classification: A61P,C07D,C07H,C12N,C12P,C12R,Y02P,Y10S

Abstract:
A method for inhibiting interleukin -2 (IL-2) production by administering to a subject in need thereof an amount of a compound of formula (I) effective to inhibit the production of IL-2: whereinR1 is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio)(lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyl-diphenyl-silyloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy, R2 is hydrogen or the same meanings as R1, R3 is methyl, ethyl, propyl or allyl, n is an integer of 1 or 2, and the symbol of a line and dotted line is a single bond or a double bond, or pharmaceutically acceptable basic salt thereof.