Patent ID: 8992984
Filing Date: 2015-03-31
Classification: A61K

Abstract:
1. A protocell comprising: a porous silica nanoparticle core comprising a plurality of pores, said nanoparticle core being formed from an aqueous precursor mixture comprising tetraethylorthosilicate (TEOS) and an amine-modified silane precursor, said porous silica nanoparticle core having an average particle size ranging from about 30 nm to about 3000 nm; and a supported lipid bilayer encasing the porous particle core and supported by the porous particle core, wherein said lipid bilayer consists essentially of a zwitterionic phosphoholipid selected from the group consisting of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), dipalmitoylphosphatidylcholine (DPPC) and a mixture thereof, and wherein said protocell, after administration to a subject, decreases non-specific binding of said protocells in said subject when compared to protocells which are encased with a lipid bilayer comprising positively or negatively charged phospholipids.