Patent ID: 7927590
Filing Date: 2011-04-19
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of inhibiting growth of a cell from a tumor that is smad4 deficient, comprising: (a) determining the level of expression of smad4 in a cell from said cancer; and (b) treating a cancer cell that is deficient in smad4 expression with one or more αvβ6 antagonist antibody that selectively binds to the integrin αvβ6 in said cancer cell, wherein said one or more antibody is an antibody from a hybridoma selected from the group consisting of 2A1 (deposited under ATCC Accession No. ATCC PTA-3896), 2E5 (deposited under ATCC Accession No. ATCC PTA-3897), 1A8 (deposited under ATCC Accession No. ATCC PTA-3647), 2B10 deposited under ATCC Accession No. ATCC PTA-3648), 2B1 deposited under ATCC Accession No. ATCC PTA-3646), 1G10 (deposited under ATCC Accession No. ATCC PTA-3898), 7G5 (deposited under ATCC Accession No. ATCC PTA-3899), 8G6 (deposited under ATCC Accession No. ATCC PTA-3645), 3G9 (deposited under ATCC Accession No. ATCC PTA-3649), or a humanized version thereof wherein said treatment results in the growth inhibition of said cancer cell.