Patent ID: 7235584
Filing Date: 2007-06-26
Classification: A61K,C07D

Abstract:
1. A compound of the general Formula (I): having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, wherein A—B indicates an optional 1(2) or 6(1) double bond, R 1 is A) R B) an amine or an amide substituted with at least one substituent as defined in R C) a thiol, a sulfide, a sulfoxide, a sulfone, a thioester or a thioamide optionally substituted with one substituent as defined in R D) an ether—OR G is (a) halogen, (b) C 1 –C 6 alkyl, or (c) —OR wherein R is (a′) —R″, wherein R″ is hydrogen or C 1 –C 6 alkyl optionally containing a terminal —OR′″ or —OC(O)R′″ moiety wherein R′″ is hydrogen or C 1 –C 6 alkyl, or (b′) —C(O)R′″ wherein R′″ is as previously defined, and R 2 is (a) C 1 –C 12 alkyl, (b) —OR″″, in which R″″ is a straight chain or branched C 2 –C 9 alkyl which may be substituted at the terminal carbon atom by a phenyl group, or (c) —(CH 2 ) n OR′″ wherein n is an integer of 1 to 7 and R′″ is hydrogen or C 1 –C 6 alkyl; with the proviso that R 1 is other than a heterocyclic moiety having a labile hydrogen atom so that said moiety acts as a carboxylic acid analogue.