Patent ID: 8212077
Filing Date: 2012-07-03
Classification: A61P,C07C,C07D

Abstract:
1. A process for the synthesis of a compound of formula (I) wherein 7-methoxy-1-naphthol of formula (II): is subjected to appropriate reaction conditions to convert the hydroxy function into a leaving group and then condensed, in the presence of palladium, with a compound of formula (III): CH wherein R represents wherein R′ and R″, which may be the same or different, each represent a linear or branched (C to yield a compound of formula (IV): wherein R is as defined hereinbefore, which is subjected to catalytic hydrogenation to yield a compound of formula (V): wherein R is as defined hereinbefore, which is subjected to base or acid hydrolysis or to a binary reducing agent/acid system to yield a compound of formula (VI) or its hydrochloride salt: which is successively subjected to the action of sodium acetate and then acetic anhydride to yield the compound of formula (I), which is isolated in the form of a solid.