Patent ID: 6511984
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A compound of the formulawherein X is NR4R5 where R4 and R5 are selected independently from C1-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C2-C8 alkynyl, C2-C8 alkoxy, alkylaryl, alkylheteroaryl, SO2R7, or SO2NR7R8; each optionally substituted with 1-2 substituents independently selected from R6; or R4 and R5 are taken together with the nitrogen to which they are attached to form a saturated nitrogen containing ring of 3 to 8 atoms, optionally substituted with 1-2 substituents independently selected from R6; an unsaturated nitrogen containing ring having 5 to 8 carbon atoms, optionally substituted with 1-2 substituents independently selected from R6; or a heterocyclic ring containing up to two heteroatoms selected from the group consisting of â€”Oâ€”, â€”NR7â€”, and â€”S(O)m â€”optionally substituted with 1-3 substituents independently selected from R6; and, furthermore, when R4 and R5 are taken together with the nitrogen to which they are attached to form said saturated nitrogen containing ring of 3 to 8 atoms, said unsaturated nitrogen containing ring having 5 to 8 carbon atoms, or said heterocyclic ring as described above then said saturated, said unsaturated or said heterocylic ring may be further substituted to form an additional 3-8 membered ring optionally containing up to two heteroatoms selected from the group consisting of â€”Oâ€”, â€”NR7â€”, and â€”S(O)mâ€”; and, furthermore, R5 may be selected from NR7R8;R6 is selected from hydrogen; halogen, nitro, cyano, hydroxy, alkylalkoxy, COOH, C1-C6 alkyl; C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, alkoxy; C1-4 alkylacyloxy, NR7NR8 , C1-C4 alkylthio, mono-, di-, or trihaloalkyl; R7 and R8 are independently selected from H, C1-C6 alkyl; C2-C6 alkenyl, alkoxy, C2-C6 alkynyl, aryl, or heteroaryl; and may be joined with the nitrogen to which they are attached to form a heterocyclic ring; Y is selected from C1-C6alkyl; alkoxyalkyl, C2-C6 alkenyl; C2-C6 alkynyl, alkoxy, aryl, or heteroaryl, or NR4R5 as defined for X; R3 is selected from aryl, optionally substituted with 1-3 substituents chosen from R6; and m is 0, 1, or 2.