Patent ID: 9187474
Filing Date: 2015-11-17
Classification: C07D

Abstract:
1. A compound of formula I wherein W is C1-C6 alkyl, optionally substituted with one or more of Z1A, Z1B, Z1C, Z1D, or Z1E; C4-C8 cycloalkyl optionally substituted with one or two Z2A or Z2B substituents; or W is C4-C8 heterocyclyl optionally substituted with one or two Z2A or Z2B substituents; each Z1A, Z1B, Z1C, Z1D, Z1E is individually and independently C1-C6 alkyl, halogen, fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated, C1-C4alkoxy, hydroxyl, fluoroC1-C4alkoxy wherein the alkyl chain is partially or completely fluorinated, cyano, C3-C8 cycloalkyl optionally substituted with one or two Z2A or Z2B substituents, phenyl optionally substituted with one to three Z2A or Z2B, or R5; each Z2A and Z2B is individually and independently hydrogen, C1-C6 alkyl, halogen, fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated, hydrogen, C1-C4alkoxy, hydroxyl, or cyano; X1 is fluoro or H; X2 is methyl, halogen, or hydrogen; R1 is selected from C1-C4alkyl, or hydrogen; R2 is C1-C6 alkyl, hydrogen, —(CH each R3 and R4 is individually and independently H, C1-C6 alkyl; each R5 is independently and individually selected from the group consisting of and wherein the symbol (##) is the point of attachment to —(CH each R5 is optionally substituted with —(R6) each R6 is individually and independently C1-C6 alkyl, —(CH R7 is C1-C6alkyl, C3-C8 cycloalkyl, hydrogen, —(CH each m is individually and independently 0, 1, 2, or 3; n is 2, 3, or 4; p is 0, 1, 2, 3, or 4; q is 0, 1, or 2.