Patent ID: 6420354
Filing Date: 2002-07-16
Classification: A61K,C07D,G01N

Abstract:
A compound of the formula: and pharmaceutically acceptable salts thereof;wherein each R20 is independently hydrogen, methyl or ethyl; and X is a linker of the formula: â€”Xâ€²â€”Zâ€”(Yâ€²â€”Z)mâ€”Yâ€³â€”Zâ€”Xâ€²â€”â€ƒin which: m is an integer of from 0 to 20; Xâ€² at each separate occurrence is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”NRâ€”, â€”C(O)â€”, â€”C(O)Oâ€”, â€”C(O)NRâ€”, â€”C(S), â€”C(S)Oâ€”, â€”C(S)NRâ€” or a covalent bond where R is as defined below; Z at each separate occurrence is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cylcoalkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, cycloalkenylene, substituted cycloalkenylene, arylene, heteroarylene, heterocyclene, or a covalent bond; Yâ€² and Yâ€³ at each separate occurrence are selected from the group consisting of: â€ƒâ€”Sâ€”Sâ€” and a covalent bond; â€ƒin which: n is 0, 1 or 2; and R, Râ€² and Râ€³ at each separate occurrence are selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl and heterocyclic.