Patent ID: 9199956
Filing Date: 2015-12-01
Classification: C07D

Abstract:
1. A green process for the production of 5-Hydroxymethyl furfural (HMF) comprising the following steps: (a) dissolving cellulose in a choline chloride-citric acid-citric acid monohydrate system to obtain a solution; (b) adding a solid acidic catalyst to the solution as obtained in step (a) and reacting for a period ranging between 5 to 25 minutes followed by adding a hybrid catalyst and then reacting for a period ranging between 90 to 120 minutes to allow the formation of a reaction mixture; (c) extracting the reaction mixture as obtained in step (b) with a liquid solvent selected from the group consisting of ethyl acetate and methyl isobutyl ketone to obtain a first liquid solvent extract containing 5-Hydroxymethyl furfural and a residual reaction mixture; (d) treating the residual reaction mixture as obtained in step (c) with the solid acidic catalyst followed by treating with the hybrid catalyst and extracting as provided in step (b) and (c) to obtain a second liquid solvent extract containing 5-Hydroxymethyl furfural and a residual reaction mixture; (e) combining the liquid solvent extracts obtained in step (c) and step (d) and distilling the combined extract to extract 5-Hydroxymethyl furfural, followed by purification of 5-Hydroxymethyl furfural by column chromatography, wherein the hybrid catalyst used in steps (b) and (d) is selected from the group consisting of γ-H-zeolite-phosphomolybdic acid and β-H-zeolite-phosphomolybdic acid, and wherein the solid acidic catalyst used in steps (b) and (d) is selected from the group consisting of Indion 225H and Indion 790.