Patent ID: 8247391
Filing Date: 2012-08-21
Classification: A61K,A61P,G01N

Abstract:
1. A gel system comprising Concanavalin A and dextran gel-forming moieties, stabilized by a network comprising a plurality of acrylic polymer backbones, formed by copolymerizing methacrylate derivatives of Concanavalin A and dextran, wherein 1) the polymer backbones are permanently cross-linked through one or more dextran moieties; and 2) pendant Concanavalin A and dextran moieties are appended to the backbones, and the pendant moieties are reversibly cross-linked, such that reversible binding controls viscosity of the gel system; wherein in absence of an analyte, all permanent and reversible cross-linkages are present and the gel system is a viscous liquid, but in presence of analyte, the reversible-cross-links between the pendant moieties are reversed, effecting increasing permeability corresponding to increasing concentration levels of analyte.