Patent ID: 7175989
Filing Date: 2007-02-13
Classification: C07K,G01N

Abstract:
1. A method of diagnosing the presence or absence of a painful, predominantly sensory, axonal polyneuropathy in an individual, the method comprising: a) contacting a trisulfated disaccharide sample comprising IdoA2S-GlcNS-6S with a test sample from the individual, wherein the test sample is selected from the group consisting of: blood, serum, cerebrospinal fluid, urine, nasal secretion, saliva, and antibodies isolated from blood, serum, cerebrospinal fluid, urine, nasal secretion, or saliva; and wherein the trisulfated disaccharide sample is contacted with the test sample under conditions that allow antibodies, if present, to bind to IdoA2S-GlcNS-6S, thereby generating a contacted sample; and b) comparing the amount of antibodies to IdoA2S-GlcNS-6S in the contacted sample with a reference amount of antibodies to IdoA2S-GlcNS-6S correlating with a diagnosis of painful, predominantly sensory, axonal polyneuropathy, wherein an amount of antibodies to IdoA2S-GlcNS-6S in the contacted sample that is equal to, or greater than, the reference amount, in the absence of selective antibody binding to myelin-associated glycoprotein, is indicative of the presence of the painful, predominantly sensory, axonal polyneuropathy.