Patent ID: 7399612
Filing Date: 2008-07-15
Classification: A61K,C07K

Abstract:
1. An isolated nucleic acid molecule encoding a fusion protein which binds and inhibits VEGF consisting of components (R1R2) x , wherein X≧1, R1 is vascular endothelial cell growth factor (VEGF) receptor component Ig domain 2 of Flt-1 (amino acids 27-126 of SEQ ID NO:8, amino acids 1-126 of SEQ ID NO:8, or amino acids 1-129 of SEQ ID NO:10) and R2 is Ig domain 3 of Flk-1 (amino acids 127-228 of SEQ ID NO:8 or amino acids 130-231 of SEQ ID NO:10).