Patent ID: 6271239
Filing Date: 2001-08-07
Classification: A61K,C07D

Abstract:
A method for blocking .delta.-opioid receptors in mammalian tissue comprising contacting said receptors with an amount of a compound of the formula: ##STR6##wherein R.sup.1 is (C.sub.1 -C.sub.5)alkyl, C.sub.3 -C.sub.6 (cycloalkyl)alkyl, C.sub.5 -C.sub.7 (cycloalkenyl)alkyl, (C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10 aryl(C.sub.1 -C.sub.5)alkyl, trans(C.sub.4 -C.sub.5)alkenyl, allyl or furan-2-ylalkyl; R.sup.2 is H, OH or O.sub.2 C(C.sub.1 -C.sub.5)alkyl; R.sup.3 is H, (C.sub.1 -C.sub.5)alkyl, or ((C.sub.1 -C.sub.5)alkyl)C.dbd.O; and R.sup.4 and R.sup.5 are individually H, F, Cl, Br, NH.sub.2, NO.sub.2, (C.sub.1 -C.sub.5)alkyl or (C.sub.1 -C.sub.5)alkoxy, or R.sup.4 and R.sup.5 together are benzo or dioxymethylene; and the pharmaceutically acceptable salts thereof, wherein the amount is effective to block .delta.-opioid receptors in said tissue.