Patent ID: 7153828
Filing Date: 2006-12-26
Classification: A61K,C07K

Abstract:
1. A method of regenerating a layer of lung epithelial cells, comprising administering to a subject an effective amount of an isolated HER2, HER3 and/or HER4 activating ligand selected from the group consisting of a HRG-βI polypeptide comprising at least 95% sequence identity to the amino acid sequence of SEQ ID NO:15, a fragment of a heregulin polypeptide, wherein the fragment comprises at least 95% sequence identity to the amino acid sequence of residues 177 to 244 of SEQ ID NO:15, the amino acid sequence of residues 147 to 227 of SEQ ID NO:15, the amino acid sequence of residues 147 to 244 of SEQ ID NO:15, or the amino acid sequence of residues 177 to 227 of SEQ ID NO:15, or a HRG agonist antibody or fragment thereof, wherein upon binding to a HER2, HER3 and/or HER4 receptor said ligand regenerates a layer of lung epithelial cells by inducing proliferation of the cells in said subject.