Patent ID: 6512112
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A compound of the formula I wherein X1 and X2 are independently â€”H, â€”F, or â€”Cl;wherein Q 1 is a structure of formula II wherein Z1 isa) â€”CH2â€”, or b) â€”CH(R5)â€”CH2â€”; wherein A1 isa) Hâ€”, or b) CH3â€”; wherein A2 isa) Hâ€”, b) HOâ€”, c) CH3CO2â€”, d) CH3â€”, e) CH3Oâ€”, f) R2Oâ€”CH2â€”C(O)â€”NHâ€”g) R3Oâ€”C(O)â€”NHâ€”, h) R4â€”C(O)â€”NHâ€”, i) (C1-C2)alkyl-Oâ€”C(O)â€”, or j) HOâ€”CH2â€”; A1 and A2 taken together are: wherein R1 isa) â€”CHO, b) â€”COCH3, c) â€”COCHCl2, d) â€”COCHF2, e) â€”CO2CH3, f) â€”SO2CH3, or g) â€”COCH2OH; wherein R2 isa) Hâ€”, b) CH3â€”, c) phenyl-CH2â€”, or d) CH3C(O)â€”; wherein R3 isa) (C1-C3)alkyl-, or b) phenyl-; wherein R4 isa) Hâ€”, b) (C1-C4)alkyl, c) aryl -(CH2)p, d) ClH2Câ€”, e) Cl2HCâ€”, f) FH2Câ€”, g) F2HCâ€”, or h) (C3-C6)cycloalkyl; wherein R5 isa) Hâ€”, or b) (C1-C3)alkyl; wherein R6 isa) Hâ€”, or b) HOH2Câ€”; n is one (1) to three (3), inclusive;p is zero (0) or one (1);wherein aryl is phenyl substituted with zero (0) or one (1) of the following:a) â€”F, b) â€”Cl, c) â€”OCH3, d) â€”OH, e) â€”NH2, f) â€”(C1-C4)alkyl, g) â€”Oâ€”C(O)â€”OCH3, h) â€”NO2, or i) â€”CN; with the following provisos:1) Z1 is â€”CH(R5)â€”CH2- wherein R5 is (C1-C3)alkyl, n is one (1), then A1 is H; and A2 is R2Oâ€”CH2â€”C(O)â€”NHâ€”, R3Oâ€”C(O)â€”NHâ€”, or R4â€”C(O)â€”NHâ€”; 2) when Z1 is â€”CH2â€”, n is one (1).