Patent ID: 7700761
Filing Date: 2010-04-20
Classification: A61P,C07H,F16H,Y02P

Abstract:
1. A process for the preparation of a 3′-deoxypentopyranosyl nucleoside, comprising the steps of: (a) bonding a 4′-protected-3′-deoxypentopyranosyl nucleoside to a solid support by coupling of the 2′-OH with a CPG support or other similar support with an amide linkage; (b) deprotecting the 4′-protected-3′-deoxypentopyranosyl nucleoside at the 4′-OH position; and (c) conjugating a linker or biomolecule to the free 4′-OH position, wherein the linker comprises a reactive group for effecting conjugation to the 4′-OH position.