Patent ID: 7851438
Filing Date: 2010-12-14
Classification: A61P,C07K,C12P

Abstract:
1. A composition of erythropoietin protein, said composition comprising a plurality of bi-antennary N-linked glycans attached to the erythropoietin, said plurality of N-linked glycans comprising greater than 25 mole percent of an N-linked glycan having the structure of N-acetylglucosamine 2 Mannose 3 N-acetylglucosamine 2 Galactose 2 N-acetylneuraminic acid 2 (GIcNAc 2 Man 3 GIcNAc 2 Gal 2 NANA 2 ), wherein a polyethylene glycol moiety is linked to the N-terminal amino acid residue of at least 50% of the erythropoietin proteins, said link being an amine linkage.