Patent ID: 6251435
Filing Date: 2001-06-26
Classification: A61K,A61L,B33Y,C08G,C08L,C09D

Abstract:
A drug delivery matrix comprising a drug, a crosslinked aliphatic polyoxaamide wherein the crosslinked aliphatic polyoxaamide is formed from an aliphatic polyoxaamide having a first divalent repeating unit of formula I:[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub. 2)--C(O)--]tm Iand a second repeating unit selected from the group of formulas consisting of:[--Y--R.sub.17 --].sub.T, II[--O--R.sub.5 --C(O)--].sub.B, III([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen and alkyl group containing 1 to 8 carbon atoms; R.sub.3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula:--[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IVwherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is 0, in which case E will be an integer in the range of from 2 to 12; R.sub.17 is an alkylene unit containing form 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an integer in the range of from 1 to 2000; R.sub.18 and R.sub.21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are selected from the group consisting of --C(R.sub.6)(R.sub.7)--, --(CH.sub.2).sub.3 --O--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, --CR.sub.8 H--CH.sub.2 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.F --C(O)-- and --(CH.sub.2).sub.K --C(O)--CH.sub.2 --; R.sub.6 and R.sub.7 are independently selected from the group consisting of hydrogen and an alkyl containing from to 1 to 8 carbon atoms; R.sub.8 selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is in integer in the range of from 1 to n such that the number average number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaamide is cross-linked; and a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate) absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.2.The drug delivery matrix of claim 1 wherein the aliphatic polyoxaamide in the matrix contains as a second repeat unit a lactone derived repeating unit derived from lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, .epsilon.-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-