Patent ID: 6436992
Filing Date: 2002-08-20
Classification: A61K,A61P,C07C

Abstract:
A method for treating a patient suffering from an auto immune disease selected from the group consisting of graft-versus host reactions, juvenile diabetes, Hashimoto's thyroiditis, Grave's disease, systemic Lupus erythematosus (SLE), Sjogren's syndrome, pernicious anaemia and chronically active (=lupoid) hepatitis comprising:administering an effective amount of a compound of a sodium, potassium, calcium, magnesium, zinc or iron salt of a funaric acid monoalkyl ester of the general formula optionally in combination with dialkyl fumarate of the formulawherein A is a bivalent cation selected from the group consisting of Ca, Mg, Zn or Fe or a monovalent cation from the series consisting of potassium or sodium, respectively, and n denotes the numeral 1 or 2 depending on the type of cation, or administering at least one alkyl hydrogen fumarate compound of the general formulaoptionally in combination with dialkyl fumarate of the formulawherein each of R, R1 and R2 is C1-C5 alkyl and may be the same or different; and optionally, in combination with commonly used pharmaceutical excipients and vehicles.