Patent ID: 8444972
Filing Date: 2013-05-21
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for detecting a tumor cell expressing an antigen recognized by antibody DMF10.62.3 in a subject, the method comprising: (a) contacting the tumor cell in the subject with an isolated antibody, or antigen-binding fragment thereof, wherein the antibody is selected from the group consisting of: (i) monoclonal antibody DMF10.62.3 produced by hybridoma cell line ATCC No. PTA-377; (ii) a chimeric version of antibody DMF10.62.3 comprising the light and heavy chain variable regions of monoclonal antibody DMF10.62.3 and human light and heavy chain constant regions, wherein said chimeric version specifically binds to the antigen to which monoclonal antibody DMF10.62.3 binds; and (iii) a humanized version of antibody DMF10.62.3 comprising the complementarity determining regions (CDRs) of monoclonal antibody DMF10.62.3, wherein said humanized version specifically binds to the antigen to which monoclonal antibody DMF10.62.3 binds, under conditions that enable specific binding; and (b) detecting any specific binding of the antibody to the tumor cell, wherein binding indicates the presence of a tumor cell in the subject.