Patent ID: 6239288
Filing Date: 2001-05-29
Classification: A61P,C07C

Abstract:
A compound of Formula I ##STR75##wherein R and R.sup.1 are the same or different and arehydrogen,alkyl,halogen,nitro,cyano,trifluoromethyl,OCF.sub.3,OCF.sub.2 H,OCH.sub.2 F,--OR.sup.6 wherein R.sup.6 is hydrogen,alkyl,aryl,arylalkyl,heteroaryl, orcycloalkyl, ##STR76##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR77##wherein R.sup.6 is as defined above, ##STR78##wherein R.sup.6 is as defined above, ##STR79##wherein R.sup.6 is as defined above,--SR.sup.6 wherein R.sup.6 is as defined above, ##STR80##wherein R.sup.6 is as defined above,--CH.sub.2 --OR.sup.6 wherein R.sup.6 is as defined above, ##STR81##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR82##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR83##wherein R.sup.6 is as defined above, ##STR84##wherein R.sup.6 is as defined above,cycloalkyl, orheteroaryl, with the proviso that R and R.sup.1 are not both hydrogen;R.sup.2 is --OR.sup.6 wherein R.sup.6 is as defined above, or ##STR85##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6 ;R.sup.3, R.sup.3a, R.sup.4, and R.sup.4a are the same or different and arehydrogen,fluorine,alkyl,--(CH.sub.2).sub.n -aryl wherein n is an integer from 1 to 6,--(CH.sub.2).sub.n -heteroaryl wherein n is as defined above,--(CH.sub.2).sub.n -cycloalkyl wherein n is as defined above,--(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -aryl wherein X is O, S, SO, SO.sub.2, or NH, and p and q are each zero or an integer of 1 to 6, and the sum of p+q is not greater than six,--(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -heteroaryl wherein X, p, and q are as defined above, or--(CH.sub.2).sub.n --R.sup.7 wherein R.sup.7 isN-phthalimido,N-2,3-naphthylimido,--OR.sup.6 wherein R.sup.6 is as defined above, ##STR86##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6,--SR.sup.6 wherein R.sup.6 is as defined above, ##STR87##wherein R.sup.6 is as defined above, ##STR88##wherein R.sup.6 is as defined above, ##STR89##wherein R.sup.6 is as defined above, ##STR90##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR91##wherein R.sup.6 is as defined above, ##STR92##wherein R.sup.6 is as defined above, ##STR93##wherein R.sup.6 is as defined above, or ##STR94##wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, and n is as defined above;R.sup.5 is OH, SH; or OR.sup.5a wherein R.sup.5a is alkyl, arylalkyl, cycloalkyl, or acyloxymethyl;with the proviso that R.sup.3, R.sup.3a, R.sup.4, and R.sup.4a are hydrogen or at least one of R.sup.3, R.sup.3a, R.sup.4, or R.sup.4a is fluorine;or corresponding isomers thereof; or a pharmaceutically acceptable salt thereof.