Patent ID: 8552181
Filing Date: 2013-10-08
Classification: A61P,C07D

Abstract:
1. A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein each of A R R alternatively, R R W is —C(═O)—, —C(═S)—, —OC(═O)—, —NHC(═O)—, —S(═O) each R alternatively, two adjacent R R R R R X is CH Z is a 3-6 membered spirocyclic ring formed of carbon atoms optionally including 1-3 heteroatoms selected from O, N and S and optionally substituted independently with 1-5 substituents of R each R or R each R m is 0, 1, 2 or 3, provided that (1) the compound is not a compound wherein Z is a four membered spirocyclic ring and R (2) the compound is not (3S)-N-((1S,2R)-1-[(3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-1-cyclobutyl-5-oxo-3-pyrrolidinecarboxamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2, 1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)tetrahydro-2-furancarboxamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2, 1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)propanamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((2S,4S)-6-ethyl-3,4,4′,5′-tetrahydrospiro[chromene-2,3′-furan]-4-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide; 2-(((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4S)-6-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)amino)-2-oxoethyl dimethylcarbamate; N˜1˜-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-N˜2˜,N˜2˜-dimethylglycinamide; Methyl (4S)-4-(((2R,3S)-4-(3-cyanophenyl)-3-[((N,N-dimethylglycyl)amino)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate; Methyl (4S)-4-(((2R,3S)-3-(acetylamino)-4-(3-cyanophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate; and Methyl (4S)-4-(((2R,3S)-4-(3-cyanophenyl)-2-hydroxy-3-(((methyloxy)acetyl)amino)butyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate.