Patent ID: 6649340
Filing Date: 2003-11-18
Classification: A61K,C07K,C12N

Abstract:
An isolated library containing a protein and mutants of said protein, wherein said protein is selected from the group consisting of: an antibody, an Fv region of an antibody, a VH chain of an antibody, and a VL chain of an antibody; wherein each mutant contains a single predetermined amino acid in one or more positions in a hypervariable region of the antigen-binding site of said protein, and the mutants collectively contain the single predetermined amino acid in every position in said hypervariable region of the antigen-binding site of said protein; and wherein the single predetermined amino acid is selected from the group consisting of: Ser, Thr, Asn, Gln, Tyr, Cys, His, Glu, Asp, Lys and Arg.