Patent ID: 7528110
Filing Date: 2009-05-05
Classification: A61K,A61P,C07K

Abstract:
1. A method for reducing late phase inflammatory responses induced by mitogen activated protein kinase activation, comprising the step of administering a therapeutically effective amount of an agent to the subject, said agent comprising a complex molecule having at least a first segment at the N terminus competent for importation of said molecule into mast cells, and a second segment at the C terminal for preventing late phase inflammatory responses induced by mitogen activated protein kinase activation within said mast cells, said first segment being a peptide and joined to said second segment through a linker, said linker providing a bend or turn at the junction between the C terminal of said first segment and the N terminus of said second segment, with the proviso that the first segment is other than the peptide AAVALLPAVLLALLAP (SEQ ID NO:27), when the second segment is the anti-allergic decapeptide derived of the C-terminal end of Gαi3 (SEQ ID NO.: 1) or Gαt (SEQ ID NO.: 2), wherein said first segment comprises 10-50 amino acids having a hydrophobic, lipid soluble portion.