Patent ID: 6492547
Filing Date: 2002-12-10
Classification: C07B,C07C,C07D

Abstract:
A carboxylic acid amide of formula I whereinR1 is a hydrogen atom, a C1-3-alkyl or trifluoromethyl group, R2 is a hydrogen, fluorine, chlorine or bromine atom or a C1-3-alkyl group, R3 is a hydrogen atom or a C1-5-alkyl group, A is a naphthyl group substituted by a fluorine, chlorine, bromine or iodine atom, by a C1-6-alkyl, C3-7-cycloalkyl, phenyl, C1-3-alkoxy, cyano, trifluoromethyl or nitro group, whilst the abovementioned monosubstituted phenyl and naphthyl groups may additionally be substituted by a fluorine, chlorine or bromine atom, by a C1-3-alkyl or C1-3-alkoxy group and the abovementioned disubstituted phenyl groups may additionally be substituted by a C1-3-alkyl or C1-3-alkoxy group, a naphthyl group, a chromane or chromene group wherein a methylene group may be replaced by a carbonyl group, or a 5- or 6-membered heteroaryl group optionally substituted in the carbon skeleton by a fluorine, chlorine or bromine atom or by a C1-3-alkyl or C1-3-alkoxy group, while the 6-membered heteroaryl groups contain one, two or three nitrogen atoms and the 5-membered heteroaryl groups contain an imino group optionally substituted by a C1-3-alkyl group, an oxygen or sulphur atom, or an imino group optionally substituted by a C1-3-alkyl group and an oxygen or sulphur atom or one or two nitrogen atoms and additionally a phenyl ring may be fused to the abovementioned monocyclic heteroaryl groups via two adjacent carbon atoms and may also be substituted in the carbon skeleton by a fluorine, chlorine or bromine atom or by a C1-3-alkyl or C1-3-alkoxy group, and B is a phenyl or naphthyl group which is substituted in each case by a carboxy group, by a group which may be converted into a carboxy group in vivo or by a group which is negatively charged under physiological conditions and may optionally additionally be substituted by a fluorine, chlorine, bromine or iodine atom or by a C1-3-alkyl, trifluoromethyl or methoxy group, whilst the abovementioned phenyl groups are additionally substituted by a C1-3-alkyl group which is substituted by an amino, C1-4-alkylamino, di-(C1-4-alkyl)-amino, C3-7-cycloalkylamino, pyrrolidino, piperidino, morpholino, piperazino or N-(C1-3-alkyl)-piperazino group, an isomer thereof or a salt thereof.