Patent ID: 6429311
Filing Date: 2002-08-06
Classification: C07D

Abstract:
A solid phase reaction component comprising a solid support, substantially insoluble in aqueous or organic reaction media, carrying a plurality of compounds of Formula I whereinR1 is an independently selected mono-, di-, tri-, or quad-substituent on the phenyl ring, wherein R1 is independently hydrogen or halogen; C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, each optionally substituted with halogen, hydroxy, C1-C6 alkoxy or C4-C10 aryl; or hydroxy, C1-C6 alkoxy, NO2, SO2Ph, phenyl, SO2NR3R4, OCOR5, SR5, CO2R5, or NHCOR5; or R1, when disubstituted, can be taken together to form a 5-7 membered carbocyclic aromatic group or heterocyclic aromatic group wherein the heterocyclic aromatic group is selected from the group consisting of furo, thieno, pyrido, pyrrolo, oxazolo, thiazolo, imidizolo, pyrazolo, isoxazolo, isothiazolo, pyridazino, pyrimidino, pyrazino, and indolo; R2 is a branched or straight chain C1-C6 alkyl, C1-C6 alkoxy, a nitrogen-protected amino acid, phenyl, benzyl, C1-C6 alkenyl, hydroxy, SO2Ph, SO2NR3R4, NR3R4, OCOR5, SR5, CO2R5, NHCOR5, or a 5-7 membered heterocyclic aromatic group; R3 and R4 are independently hydrogen, or C1-C6 alkyl or, taken together, are (CH2)f where f is 3-6; R5 is C1-C6 alkyl, benzyl, phenyl, or substituted phenyl with 1-3 substituents independently selected from the group consisting of C1-C6 alkoxy, NO2, CF3, and CN; and Y is a cleavable linker selected from the group consisting of â€”NHCO2CH2â€” and â€”Oâ€”CH2â€”; linked to a suitable solid support.