Patent ID: 6583265
Filing Date: 2003-06-24
Classification: A61K,A61P,C07K

Abstract:
A compound of formula I or a pharmaceutically acceptable salt, thereof, wherein the letters A to L represent residues of the following amino acids:A (L)-alpha-N-methylamino-beta-hydroxy acid of the formula II â€ƒwherein R1 is (E)-2-butenyl-1, B alpha-amino-butyric acid, alpha-amino-valerianic acid (norvaline), threonine, or valine, C substituted sarcosine of the formula III in which X is Oâ€”R3 or Oâ€”R10, wherein R3 is hydrogen, methyl, vinyl or allyl, and R10 is selected from the group consisting of ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 1-pentyl, 2-pentyl, 3-pentyl, isopentyl, tert-pentyl, neopentyl, hexyl and isomers of hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.1.1]hexyl, norbornyl, bicyclo[2.2.2]octyl, butenyl, pentenyl, pentadienyl, hexenyl, hexadienyl, formyl, acetyl, propionyl, butyryl, pivaloyl, benzoyl, alkoxycarbonyl, which can be substituted by hydroxy, methoxy, ethoxy, propoxy, isopropoxy, halogen, carboxy, carbamido, amino, methylamino, ethylamino, n-propylamino, isopropylamino, n-butylamino, isobutylamino, sec-butylamino, tert-butylamino, 1-pentylamino, 2-pentylamino, 3-pentylamino, isopentylamino, tert-pentylamino, neopentylamino, hexylamino and isomers of hexylamino, N,N-dimethylamino, N-methyl-N-ethylamino, N,N-diethylamino, N-propyl-N-methylamino, N-methyl-N-isopropylamino, dipropylamino, diisopropylamino, N-butyl-N-methylamino or an isomer thereof, N-butyl-N-ethylamino or an isomer thereof, N-butyl-N-propylamino or an isomer thereof, N,N-dibutylamino or an isomer thereof, azetidine, pyrrolidine, piperidine, morpholine, piperazine, Nâ€²-alkylpiperazine, azabicylo[2.1.1]hexane, azanorbornane, azabicylo[2.2.2]octane, N-formylamino, N-acetylamino, N-tert-butoxycarbonyl-amino, N-benzyloxycarbonyl-amino, N-benzoyl-amino, N-phthaloyl, or C is a residue of the formula VI [Hâ€”N+(CH3)&boxH;CHâ€”COâ€”OH]Yâˆ’â€ƒâ€ƒFormula VI, â€ƒwherein Yâˆ’ is an anion D is N-methyl-leucine, N-methyl-valine, or N-methyl-isoleucine, E is valine, F is N-methyl-leucine, G is alanine, H is glycine, (D)-alanine, (D)-serine, O-hydroxyethyl-(D)-serine, I, K are N-methyl-leucine, and L is N-methyl-valine.