Patent ID: 7714147
Filing Date: 2010-05-11
Classification: C07D,Y02P

Abstract:
1. A method of preparing a compound according to formula 1: wherein PG is a silyl protecting group and at least one of position 1, 2, 3, 4, 5, 6, 7 or 8 is bound to radical Y; Y is a radical containing a N-maleimidyl-moiety having a structure R R at least one of an available position 1, 2, 3, 4, 5, 6, 7 or 8 is optionally bound to radical X; X is —SO R R said method comprises the steps of reacting the 9-hydroxymethyl group of a compound of formula 2: wherein at least one of position 1, 2, 3, 4, 5, 6, 7 or 8 is bound to an amine, with a silyl protecting reagent introducing PG, and subsequently reacting said compound with an N-maleimidyl reagent to form the compound of formula (1).