Patent ID: 6987205
Filing Date: 2006-01-17
Classification: C12P

Abstract:
1. A process for the preparation of 1-(3-trifluoromethylphenyl)-propan-2-ol enantiomers, said method comprising the steps of: providing a lipase derived from esterifying racemic 1-(3-trifluoromethylphenyl)-propan-2-ol with an acylating agent in the presence of said lipase or performing an alcoholysis of 1-(3-trifluoromethylphenyl)-propan-2-ol esters of the following formula in the presence of said lipase: wherein R is alkyl or C 1 –C 8 alkenyl or benzoyl; and separating unreacted S-(+)1-(3-trifluoromethylphenyl)-propan-2-ol or the corresponding ester respectively from the R-(−)1-(3-trifluoromethylphenyl)-propan-2ol ester or from the R-(−)1-(3-trifluoromethylphenyl)-propan-2-ol resulting from the lipase-catalyzed esterification or alcoholysis reaction.