Patent ID: 8017363
Filing Date: 2011-09-13
Classification: C12N,C12P

Abstract:
1. A methanol-assimilating bacterium comprising: a DNA encoding dihydrodipicolinate synthase which is desensitized to feedback inhibition by L-lysine; and a DNA encoding a LysE protein which has been mutated to promote the export of L-lysine to the outside of said methanol-assimilating bacterium, wherein said bacterium is modified to enhance the intracellular activities of diaminopimelate dehydrogenase, diaminopimelate decarboxylase, dihydrodipicolinate reductase, and aspartate-semialdehyde dehydrogenase, wherein the DNA encoding dihydrodipicolinate synthase, the DNA encoding dihydrodipicolinate reductase, and the DNA encoding aspartate-semialdehyde dehydrogenase are from