Patent ID: 9085617
Filing Date: 2015-07-21
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody capable of binding to human PlGF or an antigen-binding fragment of said antibody, wherein said antibody comprises a variable heavy chain sequence of which the sequence of the CDR1, CDR2, and CDR3 region corresponds to the sequence of SEQ ID NO: 17, 18, and 19, respectively, and comprises a variable light chain sequence of which the sequence of the CDR1, CDR2, and CDR3 region corresponds to the sequence of SEQ ID NO: 20, 21, and 22, respectively, and wherein the variable heavy chain comprises the sequence of SEQ ID NO:2 comprising one or more of the amino acid changes selected from the group consisting of I2V, P9A, K40a and T111L, and the variable light chain comprises the sequence of SEQ ID NO:4 comprising one or more of the amino acid changes selected from the group consisting of S5T, S9D, A15L, K18R, R22N and L89V.