Patent ID: 6046159
Filing Date: 2000-04-04
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical formulation comprising a solution or suspension of i) an effective amount of an antineoplastic agent selected from the group consisting of peptides, proteins, enzymes, antibodies, fusion toxins, interleukins, interferons, retinoids, hydroxyurea, mitotane, PZA, bryostatin, pentosan and fumigillins; and ii) a compound of the formula: ##STR6## wherein: R.sub.1 is hydrogen, lower alkyl or ##STR7## R.sub.2 and R.sub.4 are each individually SO.sub.3.sup.- M.sup.+, PO.sub.3.sup.2- M.sub.2.sup.2+, or PO.sub.2 S.sup.2- M.sub.2.sup.2+ ;R.sub.3 and R.sub.5 are each individually hydrogen, hydroxy or sulfhydryl;m and n are individually 0, 1, 2, 3 or 4, with the proviso that if m or n is 0, then R.sub.3 is hydrogen; andM is hydrogen or an alkali metal ion; ora pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers, excipients or diluents.