Patent ID: 7977320
Filing Date: 2011-07-12
Classification: A61K,A61P

Abstract:
1. A method of increasing the efficacy of a cell-killing agent on a neoplastic cell that expresses CD33, said method comprising: exposing the neoplastic cell to a substance that increases the amount of functional Syk protein kinase, SHP-1 protein phosphatase, or both, in the neoplastic cell, determining the presence or activity level of said Syk protein, SHP-1 protein, or both in said neoplastic cell in response to the exposure, wherein the presence or level of active Syk protein, SHP-1 protein, or both is indicative of a likelihood of successful treatment of a neoplasia with said cell-killing agent, and recommending administering a therapeutically effective amount of said cell-killing agent based upon the determination of the presence or activity of said Syk protein, SHP-1 protein, or both in said neoplastic cell, thereby increasing the efficacy of the cell-killing agent on the neoplastic cell.