Patent ID: 7976845
Filing Date: 2011-07-12
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated protein comprising: a Human Cytomegalovirus (HCMV) polyepitope amino acid sequence that comprises a plurality of epitopes, wherein the epitopes are from gH, pp 28, pp 50, pp 65, pp 150, IE-1, and IE-2 HCMV antigens and are capable of eliciting a cytotoxic T-lymphocyte (CTL) response, and one or more HLA class II-restricted CTL epitopes, wherein the epitopes have an amino acid sequence selected from the group consisting of the amino acid sequences set forth in SEQ ID NOS: 6-51, and, wherein the polyepitope comprises each of the amino acid sequences set forth in SEQ ID NOS: 6-51; and an amino acid sequence of an extracellular domain of HCMV glycoprotein B, or a fragment that comprises at least 75% amino acid sequence identity thereof and comprises one or more B cell epitopes capable of eliciting a neutralizing antibody response.