Patent ID: 8372844
Filing Date: 2013-02-12
Classification: A61P,C07D

Abstract:
1. A piperazinyl-propyl-pyrazole derivative or its pharmaceutically acceptable salt represented by the following formula 1: wherein R1 is a C1-C10 alkyl group, or a substituted or unsubstituted aryl or heteroaryl group; one of R2 and R3 is a C1-C10 alkyl group, benzyl group, or substituted or unsubstituted aryl or heteroaryl group, such that only one of R2 and R3 is present which would result in a pyrazole ring; R4, R5, R6 and R7, being same or different with one another, are independently a hydrogen atom or a C1-C10 alkyl group; R8, R9, R10, R11 and R12, being same or different with one another, are independently a hydrogen atom, a halogen atom, a C1-C10 alkyl group, a C1-C10 alkoxy group, a bis(substituted or unsubstituted aryl)alkylene group, a benzyl group, a nitro group, a hydroxy group, a cyano group, an amino group, a mono or dialkylamino group, an alkylcarbonylamino group, an aminosulfonyl group, a mono or dialkylaminosulfonyl group, an alkylcarbonyl group, or an alkyloxycarbonyl group; the dotted line represents a single bond or a double bond which depends on the presence of either R2 or R3 to maintain the aromaticity of a pyrazole ring; said aryl group represents a phenyl group, said heteroaryl group represents a thiophenyl group or a pyridyl group, and said substituted aryl or heteroaryl group represents an aryl or a heteroaryl group with from 1 to 3 substituents selected from the group consisting of a halogen atom, a nitro group, a C1-C10 alkyl group, a C1-C10 alkoxy group, a C1-C10 haloalkyl group, and a C1-C10 haloalkoxy.