Patent ID: 6767541
Filing Date: 2004-07-27
Classification: A61K,C07K,C12Q

Abstract:
A method of inhibiting the growth of mammalian breast cancer cells that overexpress Her-2/neu comprising exposing the mammalian breast cancer cells to a therapeutically effective amount of an antibody that binds to a Her-2/neu epitope to which monoclonal antibody 4D5 (ATCC CRL 10463) binds and a Transforming Growth Factor-&bgr; family member selected from the group consisting of Transforming Growth Factor-&bgr;1 (TGF-&bgr;1), Transforming Growth Factor-&bgr;2 (TGF-&bgr;2) and Transforming Growth Factor-&bgr;3 (TGF-&bgr;3).