Patent ID: 6403633
Filing Date: 2002-06-11
Classification: C07D

Abstract:
A compound of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof, wherein:X is sulfur; Y is a covalent bond; Z is NR5R6; R1 is hydrogen; R3 is methyl or methylthio; R4, R5 and R6 are all hydrogen; and R2 is Formula II: â€ƒwherein Ar is thiazolyl and one of R8 and R9 is selected from the group consisting of tetrahydronaphthyl, naphthyl and optionally substituted phenyl, wherein said optionally substituted phenyl is optionally substituted with one or more substituents selected from the group consisting of alkyl, halo, aryl, alkoxy, hydroxy, nitro, alkylenedioxy, acetyloxy, methylacetyloxy, trifluoromethoxy, sulfonylamino, amidino, dialkylamino and pyridyloxy, and the other of R8 and R9 is selected from the group consisting of hydrogen, halogen, amino, mono(C1-4)alkylamino, arylamino, mono(C6-14)arylamino, di(C6-14)arylamino, mono(C6-14)ar(C1-6)alkylamino, di(C6-14)ar(C1-6)alkylamino, di(C1-4)alkylamino, formylamino, C2-6 acylamino, aminocarbonyl, C2-8 aminoacyl, C2-6 thioacylamino, aminothiocarbonyl, C2-8 aminothioacyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, carboxy, carboxy(C1-6)alkyl, C2-8 alkoxycarbonyl, nitro, cyano, trifluoromethyl, tetrazolyl, thienyl, C6-14 aryloxy, C1-6 alkylthio, C6-14 arylthio, C6-14 aryl, and C6-14 ar(C1-6)alkyl, wherein the aryl portions of any of said groups may be optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, hydroxy, amino, mono(C1-4)alkylamino, di(C1-4)alkylamino, formylamino, C1-4 acylamino, C1-4 aminoacyl, mono(C1-4)alkylaminocarbonyl, di(C1-4)alkylaminocarbonyl, thiocarbonylamino, C1-4 thioacylamino, aminothiocarbonyl, C1-4 alkoxy, C6-10 aryloxy, aminocarbonyloxy, mono(C1-4)alkylaminocarbonyloxy, di(C1-4)alkylaminocarbonyloxy, mono(C6-10)arylaminocarbonyloxy, di(C6-10)arylaminocarbonyloxy, mono(C4-12)aralkylaminocarbonyloxy, di(C4-12)aralkylaminocarbonyloxy, C1-4 alkylsulfonyl, C6-10 arylsulfonyl, C7-12 aralkylsulfonyl, C1-4 alkylsulfonylamino, C6-10 arylsulfonylamino, C7-12 aralkylsulfonylamino, C1-4 alkoxycarbonylamino, C7-12 aralkoxycarbonylamino, C6-10 aryloxycarbonylamino, mono(C1-4)alkylaminothiocarbonyl, di(C1-4)alkylaminothiocarbonyl, C7-12 aralkoxy, carboxy, carboxy(C1-4)alkyl, C1-4 alkoxycarbonyl, C1-4 alkoxycarbonylalkyl, nitro, cyano, trifluoromethyl, C1-4 alkylthio, C6-10 arylthio, 3,4-methylenedioxy, 3,4-ethylenedioxy, and 3,4-propylenedioxy.