Patent ID: 6121316
Filing Date: 2000-09-19
Classification: A61P,C07B,C07C,C07D

Abstract:
A method for the therapy of a disease or disorder characterized by increased connective tissue or cartilage degradation which comprises administering to a host in need of such therapy a pharmaceutical composition comprising a pharmaceutically effective amount of at least one compound of the formula I ##STR45## wherein R.sup.1 is a hydrogen atom or (C.sub.1 -C.sub.4)-alkyl,R.sup.2 isa) (C.sub.1 -C.sub.12)-alkyl,b) (C.sub.2 -C.sub.12)-alkenyl,c) (C.sub.2 -C.sub.12)-alkynyl,d) (C.sub.3 -C.sub.7)-cycloalkyl,f) phenyl,g) phenyl, mono- to trisubstituted by1) (C.sub.1 -C.sub.4)-alkyl,2) halogen,3) --CN,4) --CF.sub.3,5) --O--(C.sub.1 -C.sub.4)-alkyl,6) --O--(C.sub.1 -C.sub.4)-alkyl substituted by phenyl, or7) methylenedioxyl,h) (C.sub.1 -C.sub.6)-alkyl, monosubstituted by1) phenyl [or2) a radical of the formula II ##STR46## in which R.sup.5 and R.sup.6 independently of one another are 1) a hydrogen atom or2) (C.sub.1 -C.sub.4)-alkyl],i) (C.sub.2 -C.sub.6)-alkenyl, monosubstituted by1) phenyl ork) (C.sub.2 -C.sub.6)-alkynyl, monosubstituted by1) phenylR.sup.3 isa) --CF.sub.3,b) --O--CF.sub.3,c) --S--CF.sub.3,d) --OH,e) --NO.sub.2,f) halogen,g) benzyl,h) phenyl,i) --O-phenyl,j) a hydrogen atom,k) --CN,l) --O-phenyl, mono- or polysubstituted by1) (C.sub.1 -C.sub.4)-alkyl,2) halogen,3) --O--CF.sub.3 or4) --O--CH.sub.3,R.sup.4 isa) (C.sub.1 -C.sub.4)-alkyl,b) halogen, orc) a hydrogen atom, andn is the integer zero, 1, 2, 3 or 4,or of a physiologically tolerable salt of said formula I compound or of a stereoisomeric form of said formula I compound,together with a pharmaceutically suitable and physiologically tolerable carrier, additive, or auxiliary.