Patent ID: 7608403
Filing Date: 2009-10-27
Classification: C12N,G01N

Abstract:
1. A method for cancer detection, cancer progression analysis and malign tumor progression in cancer cells, comprising the steps of: detecting the expression level of the polypeptide of subunit β of H(+)-ATP synthase of the cancer cells; calculating a ration of the expression of β-F1-ATPase to Hsp60 of the cancer cells; and comparing the ration with a ratio of β-F1-ATPase to Hsp60 of one of a) control non-cancerous cells of a same cellular type as the cancer cells and b) control cancer cells of a same cellular type as the cancer cells, wherein, if the ratio of the cancer cells is lower than the ratio of the control non-cancerous cells, a presence of cancer is indicated, and wherein, if the ratio of the cancer cells is lower than the ratio of the control cancer cells, that the cancer cells are further progressed cancer cells is implied and a subject from which the cancer cells were obtained has a worse prognosis than a subject from which the control cancer cells were obtained is implied.