Patent ID: 6730809
Filing Date: 2004-05-04
Classification: C07C

Abstract:
A process for the preparation of a compound of the formula the process comprising:(a) selectively reducing a nitrile moiety of a compound of the formula wherein R1 is linear or branched C1 to C4 alkyl and Z is(i) â€”NH2 or (ii) a moiety selected from the group consisting of wherein R2 is hydrogen, linear or branched C1 to C4 alkyl or aryl, and wherein R4 is linear or branched C1 to C4 alkyl, alkoxy or aryl;(b) if present, hydrolyzing the moiety, producing, as a result of step (a), or step (a) and step (b), a compound of one of the following formulas (c) hydrolyzing the ester and amide (including the lactam) moieties of formulas 7, 9, or 10 to give the compound of formula 1.