Patent ID: 6822101
Filing Date: 2004-11-23
Classification: C07C,C07D

Abstract:
A process for preparing a compound of formula (I): or a salt thereof, whereinA is heterocyclic group selected from pyrrolidinyl or piperidinyl, wherein the heterocycle is substituted with 0, 1, 2, 3, or 4 substituents selected from the group consisting of alkyl and fluoroalkyl; and R1 is 4-cyanophenyl, the process comprising the steps of: (6a) treating a compound of formula (III-a), wherein RA1 is selected the group consisting of bromo chloro, 4-cyanophenyl; with a compound of formula (VII), wherein A is a heterocylic group selected from the group consisting of pyrrolidinyl and piperidinyl, said heterocyclic group substituted with 0, 1, 2, 3, or 4 substituents selected from the group consisting of alkyl and fluoroalkyl, to provide a compound of formula (VI-a), wherein RA1 and A are as defined above; and(6b) further treating the compound of formula (VI-a), wherein RA1 is bromo or chloro, with a compound of formula (VIII), (HO)2Bâ€”R1â€ƒâ€ƒ(VIII), or a compound of formula (VIII-a),(ReO)(RfO)Bâ€”R1â€ƒâ€ƒ(VIII-a), wherein R1 is 4-cyanophenyl; and Re and Rf are each independently alkyl or Re and Rf are taken together to form a ring, wherein the ring is substituted with 0, 1, 2, 3, or 4 substituents selected from the group consisting of alkyl or aryl.