Patent ID: 6613926
Filing Date: 2003-09-02
Classification: A61P,C07H

Abstract:
A compound having the structure of formula (III) wherein:x and y are integers in the range of 1 to 3 inclusive; LG is a leaving group displaceable by a nucleophilic moiety; R2 is selected from the group consisting of Nâˆ’â€”ClO3, Nâˆ’â€”NO2, and Nâˆ’â€”SO2R3, wherein R3 is lower alkyl, halogenated lower alkyl, halo, or amino; X is â€”X1â€”X2â€” or â€”X3&boxH;Nâ€”X1 and Y are independently selected from the group consisting of wherein Z1 is selected from the group consisting of O, S, C(CN)2, NClO3, Nâ€”NO2, Nâ€”SO3, and Nâ€”SO2R3, and Z2 is selected from the group consisting of Oâˆ’, Sâˆ’, lower alkyl, halogenated lower alkyl, halo, BH3âˆ’, Nâˆ’â€”ClO3, Nâˆ’â€”NO2, and Nâˆ’â€”SO2R3;X2 is selected from the group consisting of O, S, and Nâˆ’; X3 is wherein Z3 and Z4 are independently selected from the group consisting of Oâˆ’, Sâˆ’, lower alkyl, halogenated lower alkyl, halo, BH3âˆ’â€”, Nâˆ’â€”ClO3, Nâˆ’â€”NO2, and Nâˆ’â€”SO2R3;n is 0, 1, or 2, wherein when n is 2, the two X moieties may be the same or different; and Cat is a cationic species, with the proviso that when R2 is Nâˆ’â€”ClO3, then Y is other than