Patent ID: 6083908
Filing Date: 2000-07-04
Classification: C07K

Abstract:
A compound of formula I ##STR138## wherein R.sup.1 and R.sup.2 are independently hydrogen, or C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl;R.sup.3a is hydrogen, C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl, or aryl or hetaryl optionally substituted with one or more C.sub.1-6 -alkyl;R.sup.4a is C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl, or C.sub.1-7 -acyl;R.sup.5a is hydrogen, C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl, or aryl or hetaryl optionally substituted with one or more C.sub.1-6 -alkyl; orR.sup.3a and R.sup.4a together with the nitrogen atoms to which they are attached may form a heterocyclic system optionally substituted with one or more C.sub.1-6 -alkyl, halogen, amino, hydroxyl, aryl or hetaryl; orR.sup.3a and R.sup.5a together with the nitrogen atoms to which they are attached may form a heterocyclic system optionally substituted with one or more C.sub.1-6 -alkyl, halogen, amino, hydroxyl, aryl or hetaryl; orR.sup.4a and R.sup.5a together with the nitrogen atom to which they are attached may form a heterocyclic system optionally substituted with one or more C.sub.1-6 -alkyl, halogen, amino, hydroxyl, aryl or hetaryl;a and b are independently 0, 1 or 2; ##STR139## whereinR.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, R.sup.32, R.sup.33, R.sup.34, R.sup.35 and R.sup.36 independently are hydrogen, halogen aryl, hetaryl, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy; k and l are independently 0, 1 or 2; ##STR140## wherein R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are independently hydrogen or C.sub.1-6 -alkyl optionally substituted with one or more halogen, amino, hydroxyl, aryl or hetaryl;n, m and q are independently 0, 1, 2, or 3;p is 0 or 1;M is --CR.sup.11 .dbd.CR.sup.11a --, arylene, hetarylene, --O--, --S-- or a valence bond;R.sup.11 and R.sup.11a are independently hydrogen, or C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl; orD isR.sup.7 --NH--(CR.sup.8 R.sup.9).sub.p --(CH.sub.2).sub.m --M--(CHR.sup.10).sub.o --(CH.sub.2).sub.n --whereinR.sup.7, R.sup.8, R.sup.9 and R.sup.10 are independently hydrogen or C.sub.1-6 alkyl optionally substituted with one or more halogen, amino, hydroxyl, aryl or hetaryl; orR.sup.7 and R.sup.8 or R.sup.7 and R.sup.9 or R.sup.8 and R.sup.9 may optionally form --(CH.sub.2).sub.i --U--(CH.sub.2).sub.j --, wherein i and j independently are 1 or 2 and U is --O--, --S-- or a valence bond;n and m are independently 0, 1, 2, or 3;o and p are independently 0 or 1;M is --CR.sup.11 .dbd.CR.sup.11a --, arylene, hetarylene, --O--, --S-- or a valence bond;R.sup.11 and R.sup.11a are independently hydrogen, or C.sub.1-6 -alkyl optionally substituted with one or more aryl or hetaryl;or a pharmaceutically acceptable salt thereof.