Patent ID: 7507546
Filing Date: 2009-03-24
Classification: A61K,C07C,C07D,C07K,G01N

Abstract:
1. A method of screening a conjugate or conjugate moiety for transport by a PEPT2 transporter, comprising: providing a cell expressing a PEPT2 transporter wherein the PEPT2 transporter is from a rat, wherein the PEPT2 transporter has the amino acid sequence of SEQ ID NO:12 or has at least 90% sequence identity thereto and the PEPT2 transporter can transport Gly-Sar; contacting the cell with a conjugate or conjugate moiety in vitro; and determining whether the conjugate or conjugate moiety passes into and/or through the cell by way of the PEPT2 transporter; wherein the conjugate comprises an orally active agent having pharmacological activity.