Patent ID: 7160872
Filing Date: 2007-01-09
Classification: A61P,C04B,C07D

Abstract:
1. A method for ameliorating a disorder modulated by the CXCR4 chemokine receptor in a subject which method comprises administering to a subject in need of such treatment an effective amount of a compound of formula (I), wherein V is a 1,4,8,11-tetraazacyclotetradecanyl group, and which may optionally comprise a fused aromatic or heteroaromatic ring; R R Ar is an aromatic ring or heteroaromatic ring each said ring being optionally substituted; x is 1 or 2; or the acid addition salts and metal complexes thereof, or a pharmaceutically acceptable composition thereof; wherein said disorder comprises a deficiency in vascularization of the gastrointestinal tract, hematopoiesis, or cerebellar development; abnormal basal leukocyte trafficking; abnormal extravasation and tissue infiltration of leukocytes in response to inciting antigens; or abnormal calcium ion transport.