Patent ID: 7662623
Filing Date: 2010-02-16
Classification: C07K,C12N

Abstract:
1. An oligonucleotide construct for expression of a recombinant antibody or a recombinant antibody fragment having antigen-binding activity, wherein the antibody fragment is selected from the group consisting of Fab, F(ab′) 2 , Fv(scFv) and Fv antibody fragments, the oligonucleotide construct comprising, in the 5′ to 3′ direction, a promoter operably linked to all of (1) a coding sequence for a heavy chain of the antibody or a fragment of the heavy chain, (2) a coding sequence for a furin cleavage site, (3) a coding sequence for a 2A self-processing cleavage site and (4) a coding sequence for a light chain of the antibody or a fragment of the light chain.