Patent ID: 8489336
Filing Date: 2013-07-16
Classification: G16C

Abstract:
1. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising: a) identifying a pharmaceutical compound, wherein the pharmaceutical compound is a drug that has failed in clinical development or an approved drug; b) creating a computer model for pharmacokinetics and pharmacodynamics of the drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug of (a) from a pre-clinical trial wherein the computer model created is adjusted based on data from in vitro or in vivo studies in animals; c) performing computer simulations using the computer model with data obtained from administration of different doses of the drug and dosing intervals for different indications and patient populations in at least one phase I clinical trial; wherein the computer model is an in silico patient that is adjusted according to results of the pre-clinical trial or the at least one phase I clinical trial.