Patent ID: 6635773
Filing Date: 2003-10-21
Classification: C07D

Abstract:
A process for preparing pure citalopram that comprises purifying citalopram by selective extractions of citalopram or its impurities, said method comprising the following steps:a) extraction of citalopram dissolved in an organic solvent immiscible in water, with water at a pH of between 3.0 and 6.0, at a temperature of between 10Â° C. and 60Â° C., and separation of the aqueous phase that contains citalopram; b) washing the aqueous phase that contains citalopram proceeding from step a) with an organic solvent immiscible in water, at a pH of between 4.0 and 7.0, at a temperature of between 20Â° C. and 60Â° C., and separation of the purified aqueous phase that contains citalopram; and c) extraction of citalopram contained in the aqueous phase proceeding from step b) with a solvent immiscible in water at a pH in the interval from 5.0 to 7.5, at a temperature between 20Â° C. and 60Â° C.