Patent ID: 6288091
Filing Date: 2001-09-11
Classification: C07D

Abstract:
A compound of the formula: ##STR261##wherein:R is selected from the group consisting of hydrogen, lower alkyl, amino, lower alkylamino, di(lower alkyl)amino, lower alkanoylamino, (lower alkoxycarbonyl)amino, di(lower alkoxycarbonyl)amino, {(lower alkylamino)carbonyl}amino and pyridinylamino; andZ is:(i) NR.sup.2 --C(O)--Q--CH(R.sup.3)--NR.sup.4 R.sup.5 wherein:R.sup.2 is hydrogen or lower alkyl;Q is absent (i.e. a valance bond) or methylene;R.sup.3 is hydrogen, lower alkyl, phenyl(lower alkyl) or phenyl(lower alkyl) monosubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy or lower alkyl;R.sup.4 is hydrogen, (1-8C)alkyl, {di(lower alkyl)amino}-(lower alkyl), phenyl(lower)alkyl, phenyl(lower)alkyl monosubstituted or disubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy or lower alkyl; 1-indanyl, 2-indanyl, or (lower cycloalkyl)-(lower alkyl); andR.sup.5 is (Het)-(lower alkyl) wherein Het is pyridinyl (Het)-sulfonyl wherein Het is as defined in this claim, (Het)-(CH.sub.2).sub.n C(O) wherein Het is as defined in this claim, (Het)-Y--(CH.sub.2).sub.n C(O) wherein Het is as defined in this claim, wherein Y is oxy (--O--) or thio (--S--) and n is 0, 1 or 2 when Y is oxy or n is 1 or 2 when Y is thio;or a therapeutically acceptable acid addition salt thereof.