Patent ID: 6670364
Filing Date: 2003-12-30
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula: whereinR1, R2, and R3, are independently, hydrogen, or optionally substituted lower alkyl, alkenyl, alkynyl, cycloalkyl, cydoalkyl(lower alkyl), optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl(lower alkyl), halo(lower alkyl), â€”CF3, halogen, nitro, â€”CN, â€”OR9, â€”SR9, â€”NR9R10, â€”NR9(carboxy(lower alkyl)), â€”C(&boxH;O)R9, â€”C(&boxH;O)OR9, â€”C(&boxH;O)NR9R10, â€”OC(&boxH;O)R9, â€”SO2R9, â€”OSO2R9, â€”SO2NR9R10, â€”NR9SO2R10 or â€”NR9C(&boxH;O)R10, wherein R9 and R10 are independently, hydrogen, optionally substituted lower alkyl, lower alkyl-N(C1-2 alkyl)2, lower alkyl(optionally substituted heterocycloalkyl), alkenyl, alkynyl, optionally substituted cycloalkyl, cycloalkyl(lower alkyl), optionally substituted heterocycloalkyl(lower alkyl), aryl(lower alkyl), optionally substituted aryl, optionally substituted aryloxy, heteroaryl, heteroaryl(lower alkyl), or R9 and R10 together are â€”(CH2)4-6â€” optionally interrupted by one O, S, NH, N-(aryl), N-(aryl(lower alkyl)), N-(carboxy(lower alkyl)) or N-(optionally substituted C1-2 alkyl) group, R7 is hydrogen, optionally substituted lower alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl(lower alkyl), optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl(lower alkyl), â€”C(&boxH;O)R9, â€”C(&boxH;O)OR9, â€”C(&boxH;O)NR9R10, â€”SO2R9, or â€”SO2NR9R10, wherein R9 and R10 are independently, hydrogen, optionally substituted lower alkyl, lower alkyl-N(C1-2 alkyl)2, lower alkyl(optionally substituted heterocycloalkyl), alkenyl, alkynyl, optionally substituted cycloalkyl, cycloalkyl(lower alkyl), optionally substituted heterocycloalkyl(lower alkyl), aryl(lower alkyl), optionally substituted aryl, optionally substituted aryloxy, heteroaryl, heteroaryl(lower alkyl), or R9 and R10 together are â€”(CH2)4-6â€” optionally interrupted by one O, S, NH, N-(aryl), N-(aryl(lower alkyl)), N-(carboxy(lower alkyl)) or N-(optionally substituted C1-2 alkyl) group, R4 and R5 are, independently, hydrogen or lower alkyl, R6 is hydrogen, optionally substituted lower alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl(lower alkyl), optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aryl(lower alkyl), optionally substituted heteroaryl, optionally substituted heteroaryl(lower alkyl), â€”C(&boxH;O)R11, â€”C(&boxH;O)OR11, â€”C(&boxH;O)NR11R12, â€”SO2R11, or â€”SO2NR11R12, wherein R11 and R12 are independently, hydrogen, optionally substituted lower alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl(lower alkyl), aryl, optionally substituted aryloxy, heteroaryl, heteroaryl(lower alkyl), or R11 and R12 together are â€”(CH2)4-6â€”, or a pharmaceutically acceptable salt thereof optionally in the form of a single stereoisorner or mixture of stercoisomers thereof.