Patent ID: 7879092
Filing Date: 2011-02-01
Classification: A61C,A61L

Abstract:
1. A method for coating a recombinant bone morphogenic protein on the surface of a dental implant, comprising: i) a pretreatment step of coating the surface of the implant with titanium oxide, titanium balls, ceramic balls or calcium triphosphate, or increasing the surface area of the implant by processing the implant surface by mechanical sandblasting treatment or chemical acid corrosion treatment; ii) a step of the coating the pretreated implant with a recombinant bone morphogenic protein wherein the bone morphogenic protein is rhBMP-2; iii) freezing the BMP2-coated implant in a freezer at −75±0.5° C. for 3-4 hours (first freezing step); and iv) freeze-drying the implant of Step iii) in a freeze dryer pre-cooled to −75±0.5° C. at a pressure of 0.05-0.005 torr for 8 hours (second freeze-drying step).