Patent ID: 8173144
Filing Date: 2012-05-08
Classification: A61K,A61Q

Abstract:
1. A regime or regimen for regulating epidermal differentiation, and/or inhibiting the reduction in the amount of free amino acids in the stratum corneum related to age, and/or reducing the age-related accumulation of abnormal proteins, the regime or regimen comprising: administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: regulating epidermal differentiation, and/or inhibiting the reduction in the amount of free amino acids in the stratum corneum related to age, and/or reducing the age-related accumulation of abnormal proteins; and said effective amount of the compound of formula (I) is an amount equivalent to that observed in an in vitro measurement of protease activity for the same compound at concentrations of from 1M to 4M.