Patent ID: 7220829
Filing Date: 2007-05-22
Classification: A61K,A61P,C07K

Abstract:
1. A cytokine-binding domain of an isolated Domain 4 of a β c chain (D4β c ) of a human cytokine receptor selected from the group consisting of GM-CSF receptor, IL-3 receptor, and IL-5 receptor, and consisting of a portion of amino acid residues 338-438 of D4β c , the portion capable of binding to at least one cytokine and transducing a cytokine signal through a single cytokine receptor, said cytokine-binding domain comprising a B′-C′ loop of D4β c comprising residues Lys362, Met363, Arg364, Tyr365, Glu366, and His367, a F′-G′ loop comprising residues Thr416, Arg418, and Tyr421, and a groove located at an N-terminal end of the cytokine-binding domain where one wall of the groove is formed by the B′-C′ loop and the F′-G′ loop and the other wall of the groove is formed by residues 338-342 of D4β c .