Patent ID: 7368478
Filing Date: 2008-05-06
Classification: A61K

Abstract:
1. A method of inhibiting the interaction of MMP2 with integrin α v β 3 in a host cell, which comprises contacting the integrin with an interaction inhibiting amount of a compound represented by the formula: wherein G 1 and G 2 are each independently —NH—C(O)—O—(CH 2 ) v —(C 6 H 4 )—X 3 ; Y 1 and Y 2 are each independently —OH or C 1 -C 4 alkoxy; X 1 and X 2 are each independently halo or C 1 -C 4 alkoxy; X 3 is fluoro, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 perfluoroalkyl; Z is —C≡C—, —C 6 H 4 —, cis-CH═CH—, trans-CH═CH—, cis-CH 2 —CH═CH—CH 2 —, trans-CH 2 —CH═CH—CH 2 —, 1,4-naphthyl, cis-1,3-cyclohexyl, trans-1,3-cyclohexyl, cis-1,4-cyclohexyl, or trans-1,4-cyclohexyl; A is a covalent bond; m and n are each 1; t is 1; p and r are each 2, and v is 1.