Patent ID: 8541404
Filing Date: 2013-09-24
Classification: A61P,C07D

Abstract:
1. A method of treating hyperaldosteronism in a mammal in need thereof, the method comprising administering to the mammal a pharmaceutically effective amount of a compound of formula (I): wherein: Z is C═O or C═S; U is CR X is independently CR Y is CR b is 0; n is 0; m is 0 or 1; provided that when U is SO or SO wherein, when m is 1, the bond between U and X or U and Y, respectively, or X and Y can be a C═C or C═N double bond; Het is a ring system containing 1 or 2 rings, and at least one of the rings is aromatic and contains 5 or 6 ring atoms, of which at least one is nitrogen, and the other ring can be saturated or unsaturated and comprises from 5 to 7 ring atoms; while the ring system can contain additional 1 to 5 heteroatoms selected from the group consisting of N, S, and O, provided that not more than two heteroatoms are selected from the group consisting of S and O; and the ring system can be substituted by from one to four substituents R with the provisos that: R R R R R R R R or a pharmaceutically acceptable salt thereof.