Patent ID: 7122695
Filing Date: 2006-10-17
Classification: C07B,C07C,C07D

Abstract:
1. A process for the preparation of a compound of formula (I): wherein: R is phenyl substituted with one or more halogen; and Y is OR a. chlorinating a compound of formula (Ill) by reaction with a chlorinating agent in the presence of an inert solvent and a catalyst at a temperature of 0–200° C.; and then reacting the resulting solution with YH or Y, at an elevated temperature to provIde a compound of formula (II): reacting a trimethylsulfoxonium salt with a solid metal hydroxide in dimethyl sulfoxide at ambient or an elevated temperature to produce dimethylsulfoxonium methylide; and, contacting the compound of formula (II) with the dimethylsulfoxonium methylide in the presence of a solvent at a temperature of −10° C.–90° C.