Patent ID: 6462184
Filing Date: 2002-10-08
Classification: C07B,C07H

Abstract:
A compound of formula: wherein:T4 is hydroxyl or a protected hydroxyl; Bx is a heterocyclic base moiety; and R2 has one of formula I or II: â€ƒwherein:E is C1-C10 alkyl, N(R4)(R5) or N&boxH;C(R4)(R5); each R4 and R5 is, independently, H, C1-C10 alkyl, a nitrogen protecting group, or R4 and R5, together, are a nitrogen protecting group, or R4 and R5 are joined in a ring structure that can include at least one additional heteroatom selected from a group consisting of nitrogen and oxygen; R3 is OX, SX, or N(X)2; each X is, independently, H, C1-C8 alkyl, C1-C8 haloalkyl, C(&boxH;NH)N(H)Z, C(&boxH;O)N(H)Z or OC(&boxH;O)N(H)Z; Z is H or C1-C8 alkyl; L1, L2 and L3 comprise a ring system having from about 4 to about 7 carbon atoms or having from about 3 to about 6 carbon atoms and at least 1 heteroatom, said heteroatom being selected from a group consisting of oxygen, nitrogen and sulfur, said ring system being aliphatic, unsaturated aliphatic, aromatic, or saturated or unsaturated heterocyclic; Y is alkyl or haloalkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, alkynyl having 2 to about 10 carbon atoms, aryl having 6 to about 14 carbon atoms, N(R4)(R5)OR4, halo, SR4 or CN; each q1 is, independently, from 2 to 10; each q2 is 0 or 1; p is from 0 to 10; and r is from 1 to 10, provided that when p is 0, r is greater than 1.