Patent ID: 7820181
Filing Date: 2010-10-26
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated, infectious, self-replicating, recombinant human parainfluenza virus type 2 (HPIV2) comprising a PIV major nucleocapsid (N) protein, a PIV nucleocapsid phosphoprotein (P), a PIV large polymerase protein (L), and a partial or complete, polyhexameric recombinant HPIV2 genome or antigenome encoding one or more attenuating mutation(s) selected from amino acid substitution(s) or deletion(s) in the HPIV2 L polymerase at the amino acid corresponding to residue 11 of SEQ ID NO. 4 and/or residue 11 of SEQ ID NO. 10.