Patent ID: 9089607
Filing Date: 2015-07-28
Classification: A61K,A61P,C07C

Abstract:
1. A controlled release oral solid formulation of levodopa comprising: a. a first controlled release component comprising levodopa, a decarboxylase inhibitor and one or more rate controlling excipients, b. a carboxylic acid component comprising a carboxylic acid that is not levodopa or the decarboxylase inhibitor and one or more rate controlling excipients, c. an immediate release component comprising levodopa and a decarboxylase inhibitor, and d. a second controlled release component comprising levodopa, a decarboxylase inhibitor and one or more rate controlling excipients, the second controlled release component (d) being in a separate bead or granule from (a) and having less levodopa and decarboxylase inhibitor than (a), wherein the carboxylic acid component of (b) is in a distinct component and is coated with an enteric polymer; and wherein the first controlled release component (a), the second release component (d), the immediate release component (c) and the carboxylic acid component (b) comprise beads or granules and wherein the first and second controlled release components release decarboxylase inhibitor and levodopa at different rates.