Patent ID: 6503902
Filing Date: 2003-01-07
Classification: C07D

Abstract:
A compound of the formula (I): or a pharmaceutically acceptable salt form thereof, wherein:Q is Q1, â€”(C1-C3 alkylene)-Oâ€”Q1, â€”(C1-C3 alkylene)-Sâ€”Q1, â€”(C1-C3 alkylene)-S(&boxH;O)â€”Q1, â€”(C1-C3 alkylene)-S(&boxH;O)2â€”Q1, or â€”(C1-C3 alkylene)-N(R20)â€”Q1; Q1 is C1-C8 alkyl substituted with 0-3 R1a; C2-C8 alkenyl substituted with 0-3 R1a; C2-C8 alkynyl substituted with 0-3 R1a; C3-C10 cycloalkyl substituted with 0-3 R1b; C3-C10 carbocycle substituted with 0-3 R1b; aryl substituted with 0-3 R1b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b; R1a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, NR15R16, CF3; C3-C10 carbocycle substituted with 0-3 R1b; aryl substituted with 0-3 R1b; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b; R1b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl-Sâ€”, and (C1-C6 alkyl)-Oâ€”C(&boxH;O)â€”; R2 is H, methyl, ethyl, propyl, or butyl; R3 is H; R5 is H, OR14; C1-C6 alkyl substituted with 0-3 R5b; C1-C6 alkoxy substituted with 0-3 R5b; C2-C6 alkenyl substituted with 0-3 R5b; C2-C6 alkynyl substituted with 0-3 R5b; C3-C10 cycloalkyl substituted with 0-3 R5c; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3R5c; R5a is H, C1-C4 alkyl, or C2-C4 alkenyl; alternatively, R5 and R5a may be combined to form a 3-7 membered cycloalkyl ring substituted with 0-3 R5c; optionally the cycloalkyl ring formed by combining R5 and R5a may be benzo fused, wherein the benzo fused ring may be substituted with 0-3 R5c; R5b, at each occurrence, is independently selected from: H, C1-C6 alkyl, CF3, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl-Sâ€”, C3-C10 cycloalkyl substituted with 0-3 R5c; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c; R5c, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R6 is H or C1-C6 alkyl; W is â€”(CR8R8a)pâ€”; p is 0, 1, 2, 3, or 4; R8 and R8a, at each occurrence, are independently selected from H, F, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl and C3-C8 cycloalkyl; X is a bond; aryl substituted with 0-3 RXb; C3-C10 cycloalkyl substituted with 0-3 RXb; C3-C10 carbocycle substituted with 0-3 RXb; or 5 to 10 membered heterocycle substituted with 0-2 RXb; RXb, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; Y is a bond or â€”(CR9R9a)tâ€”Vâ€”(CR9R9a)uâ€”; t is 0, 1, 2, or 3; u is 0, 1, 2, or 3; R9 and R9a, at each occurrence, are independently selected from H, F, C1-C6 alkyl or C3-C8 cycloalkyl; V is a bond, â€”C(&boxH;O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”(R19)â€”, â€”C(&boxH;O)NR19bâ€”, â€”NR19bC(&boxH;O)â€”, â€”NR19bS(&boxH;O)2â€”, â€”S(&boxH;O)2NR19bâ€”, â€”C(&boxH;O)Oâ€”, or â€”OC(&boxH;O)â€”; Z is H; C1-C8 alkyl substituted with 0-2 R12; C2-C4 alkenyl substituted with 0-2 R12; C2-C4 alkynyl substituted with 0-2 R12; aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; Ring B is R11 is selected from H, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl substituted with 0-1 R11a; aryl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3; phenyl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl-Sâ€”, benzyl, benzoyl, C(&boxH;O)CH3, t-butoxycarbonyl, and 3,5-dimethyl-isoxazole-S(&boxH;O)2â€”; R12 at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, â€”C(&boxH;O)NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R13, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, and CF3; R14, at each occurrence, is independently selected from H, phenyl, benzyl, C1-C6 alkyl, and C2-C6 alkoxyalkyl; R14a is H, phenyl, benzyl, or C1-C6 alkyl; R15, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, (C1-C6 alkyl)-Oâ€”C(&boxH;O)â€” and (C1-C6 alkyl)-S(&boxH;O)2â€”; R16, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, (C1-C6 alkyl)-Oâ€”C(&boxH;O)â€” and (C1-C6 alkyl)-S(&boxH;O)2â€”; alternatively, â€”NR15R16 may be a heterocyclic ring selected from the group piperidinyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, homopiperidinyl, piperazinyl, and N-methylpiperizinyl; R17 is H, C1-C6 alkyl, or C2-C6 alkoxyalkyl, aryl substituted by 0-4 R17a, or aryl-CH2â€” wherein said aryl is substituted by by 0-4 R17a; R17a is H, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, â€”OH, F, Cl, Br, I, CF3, OCF3, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, â€”NH2, â€”N(CH3)2, or C1-C4 haloalkyl; R18, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€” and (C1-C6 alkyl)-S(&boxH;O)2â€”; alternatively, â€”NR18R19 may be a heterocyclic ring selected from the group: piperidinyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, homopiperidinyl, piperazinyl, and N-methylpiperizinyl; wherein said heterocyclic ring is substituted with 0-3 R11bâ€”; R19, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€” and (C1-C6 alkyl)-S(&boxH;O)2â€”; R19b, at each occurrence, is independently selected from H and C1-C6 alkyl; R20 is H, OH, C1-C4 alkyl, phenyl, benzyl, or phenethyl; R21, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, and phenethyl; and R22, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, and phenethyl.