Patent ID: 6395749
Filing Date: 2002-05-28
Classification: A61K,C07C,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, stereoisomer, or mixtures of stereoisomers; wherein:Y represents the atoms necessary to form a fused 6-membered, aromatic or non-aromatic, N-containing heterocyclic ring containing one nitrogen atom, wherein Y is unsubstituted or independently substituted with at least one non-interfering alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, carboxy or halo substituent; X is at the 1-position of ring Y and is â€”COOR5 or a substituted or unsubstituted moiety selected from the group consisting of and â€ƒwherein R7 is hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkenyl, and is itself either unsubstituted or substituted with an alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R1 is hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkenyl, and is itself either unsubstituted or substituted with an alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R2, R3, R4 and R5 are independently hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl aryl, amino, hydroxyl, 1-piperazine, 1-piperidine, or 1-imidazoline, and are either unsubstituted or substituted with a moiety selected from the group consisting of alkyl, alkenyl, alkoxy, phenoxy, benzyloxy, cycloalkyl, cycloalkenyl, hydroxy, carboxy, amino, amido, cyano, isocyano, nitro, nitroso, sulfhydryl, halo, haloalkyl, trifluoromethyl, aralkyl and aryl.