Patent ID: 6759403
Filing Date: 2004-07-06
Classification: A61K,A61P,C07D

Abstract:
A radiosensitizer comprising a pharmaceutical carrier and as an active ingredient, a compound of the formula wherein M is a single-photon-emission tomography (SPECT) imageable radiometal and/or a paramagnetic metal, at least one R is a halogen, a halogen isotope or a nitro group and seven R are selected from the group consisting of a halogen, a halogen isotope, a nitro group and hydrogen, and Y is selected from the group consisting of ortho, meta, or para O(CH2)n C2 HB9 H10 or O(CH2)n C2 HB10 H10 wherein, 0&lE;n&lE;20 and C2 HB9 H10 is nido ortho, meta- or para-carborane and C2 HB10 H10 is ortho-carborane, meta-carborane or para-carborane.