Patent ID: 6653312
Filing Date: 2003-11-25
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula wherein A is T is â€”CH2â€”, k is 1, R31 is selected from the group consisting of alkyl of 1 to 6 carbon atoms and one of the aralkyl, diaralkyl, bis-aralkyl, amino alkyl, alkylaminoalkyl, dialkylaminoalkyl and heterocycloalkyl radicals wherein the alkyl radicals each have 1 to 6 carbon atoms and the saturated or unsaturated heterocycle has 3 to 7 ring members and has at least one nitrogen with a hydrogen or alkyl substituent, X is selected from the group consisting of a bond, â€”(CH2)mâ€”, â€”(CH2)mâ€”COâ€”, â€”Oâ€”(CH2)mâ€”, â€”Sâ€”(CH2)mâ€”, â€”NR36â€”(CH2)mâ€”, â€”COâ€”NR36â€”, â€”Oâ€”(CH2)mâ€”COâ€”, â€”Sâ€”(CH2)mâ€”COâ€”, â€”NR36â€”(CH2)mâ€”COâ€”, â€”(CH2)mâ€”C(OH)(CH3)â€”COâ€”, â€”CH&boxH;CHâ€” and â€”CH&boxH;Nâ€”, Y is selected from the group consisting of a bond, â€”(CH2)nâ€” and â€”(CH2)râ€”Qâ€”(CH2)sâ€”, Q is selected from the group consisting of piperazine, homopiperazine, 2-methyl-piperazinc, 2,5-dimethyl-piperazine, 1,2,3,6-tetrahydro-pyridine, pyrrolidine, azetidine, thiazolidine and a saturated carbon ring of 3 to 7 carbon atoms , &PHgr; is selected from the group consisting of a bond, â€”(CH2)pâ€”Oâ€”(CH2)qâ€”, â€”(CH2)pâ€”Sâ€”(CH2)qâ€”, â€”(CH2)pâ€”NR37â€”(CH2)qâ€”, â€”(CH2)pâ€”COâ€”NR37â€”(CH2)qâ€” and â€”COâ€”(CH2)pâ€”NR37â€”(CH2)qâ€”, B is selected from the group consisting of alkyl of 1 to 6 carbon atoms, unsubstituted or substituted carbocyclic and heterocyclic aryl of 5 to 6 ring members with 1 to 4 heteroatoms selected from the group consisting of nitrogen and sulfur and â€ƒthe substituents being at least one member of the group consisting of alkyl, alkenyl and alkoxy of up to 6 carbon atoms, R34 and R35 are individually hydrogen or alkyl of 1 to 6 carbon atoms or together with the nitrogen form a non-aromatic heterocycle of 5 to 6 ring members selected from the group consisting of â€”CH2â€”, â€”NHâ€”, â€”Oâ€” and â€”Sâ€”, m, n, p, q, r and s are individually integers from 0 to 6, R36 and R37 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and â€”COâ€”R38, R38 is alkyl or alkoxy of 1 to 6 carbon atoms, R39 is hydrogen or alkyl of 1 to 6 carbon atoms or its non-toxic, pharmaceutically acceptable salts.