Patent ID: 6627644
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A compound comprising Formula I wherein:A is â€”C(O)R4 or â€”S(O)2R5; R1 is (C1-6)alkyl or allyl; R2 and R3 are independently in each occurrence hydrogen, halogen, (C1-6)alkyl, haloalkyl, â€”ORâ€², â€”S(O)0-2Râ€², â€”NRâ€²Râ€³, â€”NRâ€²CORâ€³, â€”NRâ€²â€³CONRâ€²Râ€³, â€”NRâ€²SO2Râ€³, â€”NRâ€²â€³SO2NRâ€²Râ€³, â€”SO2NRâ€²Râ€³, â€”OSO2Râ€², nitro, cyano, heteroaryl, or aryl, wherein said heteroaryl or aryl group is optionally substituted with one or more groups selected from hydroxy, cyano, (C1-6)alkyl, (C1-6)alkoxy, haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylaminocarbonyl, and alkylcarbonylamino, with the proviso that R2 and R3 are not both hydrogen; with the proviso that R2 and R3 are not both hydrogen; Râ€², Râ€³, and Râ€²â€³ are independently in each occurrence hydrogen, (C1-6)alkyl, (C3-6)cycloalkyl, haloalkyl, diphenylmethyl, aryl or aryl(C1-6)alkyl, wherein the aryl group is optionally substituted with one or more groups selected from hydroxy, cyano, (C1-6)alkyl, (C1-6) alkoxy, haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylaminocarbonyl, alkylcarbonylamino and phenyl, heterocycyl, wherein the heterocylcyl group is optionally substituted with one or more groups selected from hydroxy, oxo, cyano, (C1-6)alkyl, (C1-6) alkoxy, haloalkoxy, alkylthio, halo, and haloalkyl, heteroaryl, wherein the heteroaryl is optionally substituted with one or more groups selected from (C1-6)alkyl, (C1-6)alkoxy, and halogen, or Râ€² and Râ€³ together with the nitrogen they are attached may also form a 5- to 7-membered ring, optionally incorporating one additional heteroatom chosen from O, N, or S(O)0-2, said ring being optionally substituted with one or two (C1-6)alkyl groups; R4 is (C1-6)alkyl, haloalkyl, benzyloxy, diphenylmethyl, â€”NRaRb, wherein Ra and Rb are as defined herein, â€”Y-heterocyclyl, â€”Y-heteroaryl, wherein the heterocyclyl and heteroaryl groups are independently of each other optionally substituted with one or more groups selected from (C1-6)alkyl, (C1-6)alkoxy, halo, haloalkyl, alkylsulfonyl, alkylaminosulfonyl, and alkylsulfonylamino, and wherein Y is a bond or (C1-3)alkylene; Ra is hydrogen, (C1-6)alkyl, haloalkyl, cycloalkyl or aryl, wherein the cycloalkyl or the aryl group are each independently of each other optionally substituted with (C1-6)alkyl, (C1-6)alkoxy, halo, haloalkyl, and alkylsulfonyl, or Ra and Rb together with the nitrogen they are attached may also form a 5- to 7-membered ring, optionally incorporating one additional heteroatom chosen from O, N, or S(O)0-2, said ring being optionally substituted with one or two (C1-6)alkyl groups; Rb is hydrogen or (C1-6)alkyl; R5 is (C1-6)alkyl, haloalkyl, â€”NRaRb, wherein Ra and Rb are as defined above, aryl or heteroaryl, wherein the aryl or heteroaryl are each independently of each other optionally substituted with one or two groups selected from (C1-6)alkyl, (C1-6)alkoxy, halo, and alkylsulfonyl; and p is an integer from 1 to 2 inclusive; or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof.