Patent ID: 6451325
Filing Date: 2002-09-17
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A composition comprising:(1) an adjuvant composition consisting essentially of: (a) a metabolizable oil, wherein the oil is present in an amount of 0.5% to 15% of the total volume and (b) an emulsifying agent, wherein the emulsifying agent is 0.01% to 2.5% by weight (w/w), and wherein said oil and said emulsifying agent are present in the form of an oil-in-water emulsion having oil droplets substantially all of which are about 100 nm to less than 500 nm in diameter and wherein said composition exists in the absence of any polyoxypropylene-polyoxyethylene block copolymer; and (2) an antigenic substance, wherein said antigenic substance is not present in the internal phase of the adjuvant composition and further wherein said adjuvant composition is capable of increasing the immune response to the antigenic substance.