Patent ID: 9161944
Filing Date: 2015-10-20
Classification: A61K,A61P,C07H

Abstract:
1. A method for inhibiting or treating cancer metastasis with no effect on primary tumor growth, comprising a step of administering to a patient in need thereof a glycerolipid is selected from the group consisting of the compounds (A)-(K) and (M)-(O) below: wherein R3 means a Gal-β-(1-4)-Glu group, also termed lactose wherein R3 means a Gal-α-(1-4)-Glu group wherein R3 means a Glu-β-(1-4)-Glu group, wherein R3 means a Glu-α-(1-4)-Glu group, also termed maltose, wherein R 71 and R 72 are independently selected from the group consisting of a hydrogen atom and a hydroxyl group or acetyl group, which encompasses (i) Gal-β-(1-6)-Glu when R 71 is H and R 72 is OH or OAcl and (ii) Glu-β-(1-6)-Glu when R 71 is OH or OAc and R 72 is H, wherein R 71 and R 72 are independently selected from the group consisting of a hydrogen atom and a hydroxyl group or acetyl group, which encompasses (i) Gal-α-(1-6)-Glu when R 71 is H and R 72 is OH or OAc, also termed melibiose or acetylmelibiose and (ii) Glu-α-(1-6)-Glu when R 71 is OH or OAc and R 72 is H, wherein R 71 and R 72 are independently selected from the group consisting of a hydrogen atom and a hydroxyl group or acetyl group, which encompasses (i) Gal-β-(1-6)-Gal when R 71 is H and R 72 is OH or OAc and (ii) Glu-β-(1-6)-Gal when R 71 is OH or OAc and R 72 is H wherein R 71 and R 72 are independently selected from the group consisting of a hydrogen atom and a hydroxyl group or acetyl group, which encompasses (i) Gal-α-(1-6)-Gal when R 71 is H and R 72 is OH or OAc and (ii) Glu-α-(1-6)-Gal when R 71 is OH or OAc and R 72 is H, wherein R 4 means a Gal-β-(1-4)-Glu group, also termed lactose or acetyllactose, wherein R 4 means a Glu-α-(1-4)-Glu group, also termed maltose or acetylmaltose, wherein R 71 and R 72 are independently selected from the group consisting of a hydrogen atom and a hydroxyl group or acetyl, which encompasses (i) Gal-α-(1-6)-Glu when R 71 is H and R 72 is OH or OAc, also termed melibiose or acetylmelibiose, and (ii) Glu-α-(1-6)-Glu when R 71 is OH or OAc and R 72 is H.