Patent ID: 8298565
Filing Date: 2012-10-30
Classification: A61F,A61L,A61P,Y10T

Abstract:
1. A method for coating a substrate, said coating comprising at least one polymer; and at least one pharmaceutical agent in a therapeutically desirable morphology; said method comprising the following steps: a) discharging the at least one pharmaceutical agent in dry powder form through a first orifice; discharging the at least one polymer in dry powder form through a second orifice; depositing polymer and pharmaceutical agent particles onto said substrate, wherein an electrical potential is maintained between the substrate and the polymer and pharmaceutical agent particles, thereby forming said coating; and then b) sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent, wherein said sintering comprises treating said coated substrate with a compressed gas, compressed liquid or supercritical fluid that is a non-solvent for both the polymer and the pharmaceutical agent, wherein the therapeutically desirable morphology of said pharmaceutical agent is crystalline or semi-crystalline.