Patent ID: 6075041
Filing Date: 2000-06-13
Classification: C07C,C07D

Abstract:
A compound of the formula: ##STR11## in which: R.sup.5 is o-phenylene, substituted or unsubstituted with 1 to 3 substituents each selected independently from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy , acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halo;R.sup.7 is (i) cyclic alkyl of 1 to 12 carbon atoms, (ii) pyridyl, (iii) phenyl substituted with one or more substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amin o, alkyl of 1 to 10 carbon atoms, alkoxy of i to 10 carbo n atom s, or halo, (iv) benzyl unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomnthoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halo, (v) naphthyl, (vi) benzyloxy, (vii) imidazole-4-ylmethyl, or (viii) straight or branched alkyl of 1 to 12 carbon atoms when n=1;R.sup.12 is --OH, alkoxy of 1 to 12 carbon atoms, --O--CH.sub.2 -pyridyl, --O-benzyl, or ##STR12## in which: R.sup.8' is hydrogen or alkyl of 1 to 10 carbon atoms; andR.sup.9' is hydrogen, alkyl of 1 to 10 carbon atoms, --CH.sub.2 -pyridyl, benzyl, --COR.sup.10,or--SO.sub.2 R.sup.10 in which R.sup.10 is hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl; andn has a value of 0, 1, 2, or 3.