Patent ID: 7390630
Filing Date: 2008-06-24
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of identifying a compound that selectively inhibits cytokine-stimulated T cell (T ck cell) induced production of TNFα by monocytes at least two-fold greater than the compound inhibits T cell antigen receptor-stimulated T cell (T tcr cell) induced production of TNFα by monocytes wherein said method comprises the following steps: (a) providing a population of T (b) providing a population of T (c) incubating separate cultures of T (d) resuspending the cultures of T (e) fixing the cultures of T (f) co-culturing equal portions of each of said fixed T (g) assaying for TNFα production by said monocytes, wherein the method identifies a compound that selectively inhibits T