Patent ID: 7125896
Filing Date: 2006-10-24
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) in which: R X represents O; R A represents a pyridyl group; said pyridyl group being optionally substituted by one or more substituents selected independently from halogen, cyano, nitro, —NR n represents an integer 1 or 2; and when n represents 2, each R R W represents O or S; Z represents a bond; Z represents: (a) a phenyl ring or a 5- or 6-membered heteroaromatic ring containing one to three heteroatoms selected independently from O, N and S; said phenyl or heteroaromatic ring being optionally substituted by one or more substituents selected independently from halogen, cyano, —NR (b) a 3- to 8-membered saturated or partially unsaturated monocyclic or saturated bicyclic ring system optionally incorporating one or two heteroatoms selected independently from O, N and S, and optionally incorporating a carbonyl group; said ring system being optionally substituted by one or more substituents selected independently from halogen, cyano, —NR (c) if W represents O, then Z may also represent hydroxyl, CF R R R R R R m, s, u and v independently represent an integer 0, 1 or 2; t represents an integer 2, 3 or 4; and pharmaceutically acceptable salts thereof: with the proviso that the following two compounds are excluded: 2-[(aminocarbonyl)amino]-5-(4-[2-(1-(2,2,6,6-tetramethyl)piperidinyl)ethoxy]phenyl)-3-thiophenecarboxamide; 2-[(aminocarbonyl)amino]-5-(4-(thiazol-4-yl-methoxy)phenyl)-3-thiophenecarboxamide.