Patent ID: 8115012
Filing Date: 2012-02-14
Classification: C07D

Abstract:
1. A process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of formula (I) wherein R 1 is C 1 -C 8 -alkyl, C 3 -C 8 -cycloalkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 8 -cycloalkoxy-C 1 -C 4 -alkyl, C 2 -C 8 -alkenyl or is benzyl which is optionally substituted by 1, 2 or 3 substituents R y1 independently of one another selected from the group consisting of C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and nitro; and R 2 is hydrogen, C 1 -C 4 -alkyl, benzyl or phenyl, where the two last-mentioned substituents may be unsubstituted or optionally substituted by 1, 2 or 3 substituents R y2 independently of one another selected from the group consisting of halogen, CN, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy; wherein a) a compound of the general formula (II) in which X is fluorine, chlorine or bromine, R in which n is 1, 2 or 3 and the substituents R with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R