Patent ID: 6162817
Filing Date: 2000-12-19
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR13## wherein R.sup.1 is a hydrogen, C.sub.1-4 alkyl, --CR.sup.3 R.sup.4 CO.sub.2 H, --(CH.sub.2).sub.2 --NR.sup.5 R.sup.6 ;R.sup.2 is hydrogen, C.sub.1-4 alkyl; or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached, is a heterocyclic ring selected from piperazine, N-methyl piperazine, piperidine, thiomorpholine and morpholine;R.sup.3 is hydrogen or methyl;R.sup.4 is hydrogen; or substituted or unsubstituted C.sub.1-4 alkyl in which the substituent is selected from the group consisting of hydroxy, amino, methylthio, carboxyl, carboxamide, guanidino, phenyl and hydroxyphenyl; andR.sup.5 and R.sup.6 each are independently hydrogen, C.sub.1-4 alkyl; or R.sup.5 and R.sup.6, taken together with the nitrogen atom to which they are attached, is a heterocyclic ring selected from piperazine, N-methyl piperazine, piperidine, thiomorpholine and morpholine;or a nontoxic pharmaceutically acceptable salt or solvate thereof.