Patent ID: 6929910
Filing Date: 2005-08-16
Classification: A61K,C07K,C12Q

Abstract:
1. A method of examining a test biological sample comprising a human breast, ovarian or lung cell for evidence of altered cell growth that is indicative of a breast, ovarian or lung cancer, the method comprising evaluating levels of H37 polynucleotides that encode the H37 polypeptide shown in SEQ ID NO: 2 in a test biological sample, wherein a decrease in the levels of said H37 polynucleotides in the test biological sample relative to a normal tissue sample provide evidence of altered cell growth that is indicative of a breast, ovarian or lung cancer; and wherein the levels of said H37 polynucleotides in a sample are evaluated by contacting the sample with a polynucleotide probe that specifically hybridizes to a H37 nucleotide sequence shown in SEQ ID NO: 1 and evaluating the presence of a hybridization complex formed by the hybridization of the polynucleotide probe with said H37 polynucleotides in the sample.