Patent ID: 8088357
Filing Date: 2012-01-03
Classification: A61K,C07K

Abstract:
1. A recombinant recognition molecule comprising variable heavy (VH) and variable light (VL) antibody framework sequences and complementarity determining regions (CDRs) comprising the amino acid sequences set forth in (i) the amino acid sequence SEQ ID NO. 1, (ii) the amino acid sequences SEQ ID NO.2 or 3, (iii) the amino acid sequence SEQ ID NO.4, 5 or 6, (iv) the amino acid sequence SEQ ID NO.7 or 8 or 9, (v) the amino acid sequence SEQ ID NO. 10 or 11, and (vi) the amino acid sequence SEQ ID NO. 12 or 13, wherein the antibody framework sequences a) FRH1, FRH2, FRH3 and FRH4 for the variable heavy chain VH are the following amino acid sequences, the amino acid position corresponding to the numbering according to Kabat: b) FRL1, FRL2, FRL3 and FRL4 for the variable light chain VT, are the following amino acid sequences, the amino acid position corresponding to the numbering according to Kabat: and which specifically binds to the core 1 antigen.