Patent ID: 6297250
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A pyrimidopyrimidine compound which is a compound having the structural formula I ##STR54##or a pharmaceutically acceptable salt thereof,characterised in that in structural formula IR.sub.1 and R.sub.3 are identical and are selected from allyl, diethanolamino, solketalo and a group having the formula --O--R.sub.Z or --NHR.sub.z,R.sub.Z being selected from alkyl, hydroxyalkyl, alkoxyalkyl, dialkoxyalkyl and 2-oxo-alkyl wherein the or each alkyl and/or alkoxy moiety has less than six carbon atoms, andR.sub.2 and R.sub.4 are identical and are selected from N-tetrahydroisoquinolyl, and a benzylamino group having the structural formula II ##STR55##whereR.sub.5 is H, or an optionally substituted alkyl or benzyl group, andR.sub.6 and R.sub.7 represent H or optional substituents in the aromatic nucleus selected from halo, alkyl, alkoxy, hydroxy, trifluoromethyl, azido, cyano, nitro, carboxyl, carboxylic ester, amino or a substituted amino NR.sub.x R.sub.y where R.sub.x and R.sub.y each represent hydrogen or alkyl,subject to the proviso thatif R.sub.1 and R.sub.3 are both diethanolamino, R.sub.2 and R.sub.4 do not correspond to structure II with R.sub.5, R.sub.6 and R.sub.7 each being hydrogen and provided further that, if R.sub.1 and R.sub.3 are --NHR.sub.z and R.sub.2 and R.sub.4 are both benzylamino groups of formula II, R.sub.5 is hydrogen.