Patent ID: 6207836
Filing Date: 2001-03-27
Classification: A61P,C07D

Abstract:
A compound represented by formula (I): ##STR209##wherein R.sub.1 represents a halogen atom; a lower alkyl group having 1-6 carbon atoms; a lower alkoxy group having 1-6 carbon atoms; a hydroxyl group; a nitro group; a trifluoromethyl group; a lower alkylthio group; a carbonyl group which is substituted by a hydrogen atom, a lower alkyl group, a carbocyclic aryl group having 6-14 carbon atoms, a lower alkoxy group or an amino group; a carboxyl group; a mercapto group; or a substituted or unsubstituted amino group;R.sub.2 represents a hydrogen atom; a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms; a substituted or unsubstituted lower alkenyl group having 2-6 carbon atoms; a substituted or unsubstituted lower alkynyl group having 2-6 carbon atoms; a substituted or unsubstituted lower alkoxy group having 1-6 carbon atoms; a substituted or unsubstituted carbonyl group which is substituted by a hydrogen atom, an alkyl group, a carbocyclic aryl group having 6-14 carbon atoms, a lower alkoxy group or an amino group; a substituted or unsubstituted aryl group having 6-14 carbon atoms;R.sub.3 represents a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms; a substituted or unsubstituted cycloalkyl group having 3-8 carbon atoms; a substituted or unsubstituted aryl group having 6-14 carbon atoms; a menthyl group or an adamantyl group;R.sub.4 represents --OR.sub.5 ; --SR.sub.5 ; or --NR.sub.6 R.sub.7, wherein R.sub.5 and R.sub.6 each represent a substituted or unsubstituted pyridyl group and R.sub.7 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms, a substituted or unsubstituted aryl group selected from the group consisting of phenyl and naphthyl, a lower alkoxy group or a substituted or unsubstituted amino group;X and Y, which may be the same or different, each represent --CH.sub.2 --, --NH-- or --O--; andn represents an integer of from 0 to 4;wherein the substituents in the definition of R.sub.1 to R.sub.7 represent a halogen atom; a lower alkyl group having 1-6 carbon atoms; a C3-C8 cycloalkyl group; a C6-C14 aryl group; a hydroxyl group; a lower alkoxy group having 1-6 carbon atoms; a C6-C14 aryloxy group; a lower alkylthio group; --CH(OR').sub.2, wherein R' represents a lower alkyl group having 1-6 carbon atoms; a lower alkylcarbonyl group; a C6-C14 arylcarbonyl group; a carboxyl group; a lower alkoxycarbonyl group; an amino group which may be substituted with one to two methyl groups, an ethyl group or a trifluoromethylcarbonyl group; an imino group; --CR""(SR').sub.2, wherein R' and R"" represent a lower alkyl group having 1-6 carbon atoms; a nitro group; a nitrile group; or a trifluoromethyl group; or a salt thereof or an optically active isomer thereof.