Patent ID: 6103722
Filing Date: 2000-08-15
Classification: A61K,A61P

Abstract:
A method for reducing ischemic damage to an organ having a delta .delta. opioid receptor in a mammal, comprising the step of:administering to said mammal a therapeutically effective amount of an agonist to the delta .delta. opioid receptor in a suitable carrier,wherein the agonist is represented by the formula: ##STR4## wherein R.sub.1 represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, a cycloalkylalkyl group having 4-7 carbon atoms, a cycloalkenylalkyl group having 5-7 carbon atoms, an aralkyl group having 7-14 carbon atoms, an alkenyl group having 4-5 carbon atoms, an allyl group, a furan-2-yl alkyl group, a thiophen-2-yl alkyl group, an alkanoyl group having 1-5 carbon atoms, a benzoyl group, a vinyloxycarbonyl group, a 2,2,2-trichloroethoxycarbonyl group, a benzyloxycarbonyl group, or an arylalkanoyl group having 8-14 carbon atoms;R.sub.2 represents a hydrogen atom or OR.sub.5, wherein R.sub.5 represents a hydrogen atom or an alkanoyl group having 1-5 carbon atoms;R.sub.3 and R.sub.3 ' each independently represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, fluorine, chlorine, bromine, iodine, an alkoxy group having 1-5 carbon atoms, a nitro group, an amino group, or an alkylamino group;R.sub.4 represents a hydrogen atom, an alkyl group having 1-3 carbon atoms, a benzyl group, or an alkanoyl group having 1-5 carbon atoms; andX represents CH or N.