Patent ID: 9187732
Filing Date: 2015-11-17
Classification: A61K,C07K,C12N

Abstract:
1. A replication deficient influenza virus, characterized in that the virus comprises: a) a modified NS segment coding for a NS1 protein comprising at least one amino acid modification within positions 1 to 73 resulting in a complete lack of functional RNA binding and at least one amino acid modification between position 74 and the carboxy-terminal amino acid residue resulting in a complete lack of effector function, and b) a heterologous sequence between a functional splice donor site and a functional splice acceptor site inserted in the NS gene segment, wherein the virus comprises a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:78, and SEQ ID NO:79.