Patent ID: 6444662
Filing Date: 2002-09-03
Classification: A61P,C07C

Abstract:
Salts of hyperforin and adhyperforin of formula I[Aâˆ’]m[B]p+â€ƒâ€ƒ(I) in whichm is a whole number from 1 to 3, and [B]p+ is an ion of an alkali metal or an ammonium ion of a salt-forming nitrogen base of formula III â€ƒwherein R1, R2 and R3 independently of one another, are a hydrogen atom, a straight-chain or branched alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl, alkenyl, alkynyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl group, or a derivative of the said groups which include one or more hydroxy, alkoxy, aryloxy, alkanoyl, aroyl, carboxy, alkoxycarbonyl, amino, alkylamino, hydroxylamino, carboxamido having the formula (lower alkyl) â€”COâ€”NHâ€”, carbamoyl, ureido, amidino, guanidino, cyano, azido, mercapto, alkylthio, alkylsulphonyl, alkylsulphenyl, aminosulphonyl, fluoro, chloro, bromo, iodo, alkyl or perfluoroalkyl groups, or wherein the residues R1 and R2 together with the N atom are an azetidine, pyrrolidine, pyrroline, piperidine, piperazine, homopiperazine, morpholine, thiomorpholine, pyridine, di- or tetrahydropyridine, pyrimidine, pyrazine, azepine, thiomorpholine, pyridine, di- or tetrahydropyridine, pyrimidine, pyrazine, azepine, dihydroazepine, oxazepine, diazepine, imidazole, pyrazole, oxazole, or thiazole ring, or one of the said rings which exhibits aliphatic, heteroaliphatic, aromatic or heteroaromatic rings condensed on to it and/or is substituted with one or more hydroxy, alkoxy, aryloxy, alkanoyl, aroyl, carboxy, alkoxycarbonyl, amino, alkylamino, hydroxylamino, amido, carbamoyl, ureido, amidino, guanidino, cyano, azido, mercapto, alkylthio, alkylsulphoxy, alkylsuphonyl, alkylsulphenyl, aminosulphonyl, fluoro, chloro, bromo, iodo, alkyl or perfluororoalkyl residue(s), and wherein the residue R4 is a hydrogen atom or a straight-chain or branched alkyl group, in which p=m and give the total number of positive charges of the residue [B].