Patent ID: 8956643
Filing Date: 2015-02-17
Classification: A61L

Abstract:
1. An intelligent porous biodegradable polymer scaffold for in situ tissue regeneration of the musculoskeletal system comprising: a polymer scaffold having a surface modified with a carboxyl group-containing hydrophilic monomer; a first physiologically active substance introduced into the inside of the polymer scaffold, wherein the first physiologically active substance is selected from the group consisting of dexamethasone, β-glycerophosphate, ascorbate-2-phosphate, ascorbate, demineralized bone matrix (DBM), hydroxyapatite (HAP), ascorbic acid, 1,25-dihydroxyvitamin D a second physiologically active substance conjugated to the surface of the polymer scaffold via heparin immobilized on the hydrophilic monomer, wherein the second physiologically active substance is selected from the group consisting of dexamethasone, β-glycerophosphate, ascorbate-2-phosphate, ascorbate, demineralized bone matrix (DBM), hydroxyapatite (HAP), ascorbic acid, 1,25-dihydroxyvitamin D