Patent ID: 6613896
Filing Date: 2003-09-02
Classification: A61P,C07D,C07H

Abstract:
A method of synthesizing a nucleoside according to Structure A, comprising:providing a compound according to Structure B wherein L is a reactive group selected from the group consisting of CN, CHO, or halogen; in a single step reacting L of Structure B to form Structure D having a heterocyclic ring; and in a single step aromatizing the heterocyclic ring; wherein the step of reacting L of Structure B to form Structure D comprises reacting Structure B with Structure C wherein A is O, S, CH2, or NR where R is H or a blocking group; X is O, S, Se or NH; R1, R2, R3, and R4 are independently H or lower alkyl; B1, B2, and B3 are independently blocking groups or lower alkyl, and Z1, Z2, and Z3 are independently H or non-H.