Patent ID: 8546404
Filing Date: 2013-10-01
Classification: A61P,C07D

Abstract:
1. A compound of formula 1.0: or the pharmaceutically acceptable salts, esters and solvates thereof, wherein: Y —CH═, and —CR 9 ═; z is 1 to 3; Q is a substituent selected from the group consisting of: Z m is 1 to 6; n is 1 to 6; p is 0 to 6; t is 0, 1, or 2; R wherein each R 10 is independently selected, wherein each R 10 is independently selected, R wherein each alkyl is independently selected, which each alkyl is independently selected, wherein each alkyl is independently selected, each R wherein said R wherein said R R R each R each R said R said R (19) —NHR 20 , (20) cycloalkyl, (21) —O-alkyl-O—R 20 , (22) hydroxyalkyl, (23) —N(R 20 ) 2 wherein each R 20 is independently selected, (24) -alkyl-OR 20 , (25) —O-alkyl-OH, (26) —NH(hydroxyalkyl), and (27) oxazolidinone; R R R R R R each R R each R each R each R R each R said R said R (18) and (19) —NHR 20 ; R R Each R