Patent ID: 8946425
Filing Date: 2015-02-03
Classification: A61P,C07B,C07D,C07F

Abstract:
1. A process for preparing a compound of Formula 1: or a pharmaceutically acceptable salt thereof, wherein R 1 is —H, —Cl or —F; comprising the steps of: iva) reacting a compound of Formula 5 with bromine in an organic solvent to generate a compound of Formula 6: va) reacting the compound of Formula 6 with p-toluenesulfonyl chloride to generate a compound of Formula 7: vi) reacting the compound of Formula 7 with triisopropyl borate, in the presence of an organic solvent and a strong lithium base to generate a compound of Formula 8:  and vii) esterifying the compound of Formula 8 with pinacolate alcohol in an organic solvent to generate a compound of Formula 1.