Patent ID: 8377935
Filing Date: 2013-02-19
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), an N-oxide form, a pharmaceutically acceptable addition salt or a stereo-chemically isomeric form thereof, wherein: X is N or CH; Y is independently 0, CH or CH 2 and when Y is CH then the substituent is attached to the Y atom of the ring structure; n is 0 or 1 and when n is 0 than a direct bond is intended; R 1 is phenyl, naphthalenyl or heterocyclyl; wherein each of said phenyl or naphtalenyl is optionally substituted with one or two substituents that are each independently halo, C R 2 is —CH 2 —R 5 , trifluoromethyl, —C(═O)—R 6 , or —CH 2 —NR 7 R 8 ; wherein each R each R N-methylpiperazinyl, morpholinyl or thiomorpholinyl; each R C R 3 is hydrogen, C 1-6 alkyl, cyanoC 1-4 -alkyl, C 1-6 alkyloxycarbonyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 cycloalkyl, C 3-6 cycloalkylC 1-6 alkyl, arylC 1-6 alkyl, C 1-6 alkylcarbonyl, or C 1-6 alkylsulfonyl; R 4 is hydroxy or a radical of formula (a-1) wherein R R R wherein R heterocyclyl in the above is furanyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, dioxolyl, oxazolyl, thiazolyl, imidazolyl, imidazolinyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyranyl, pyridinyl, piperidinyl, dioxanyl, morpholinyl, dithianyl, thiomorpholinyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperazinyl, triazinyl, trithianyl, indolizinyl, indolyl, indolinyl, benzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzthiazolyl, purinyl, quinolizinyl, quinolinyl, cinnolinyl, phthlazinyl, quinazolinyl, quinoxalinyl or naphthyridinyl; wherein each of said heterocycles is optionally substituted with one or two substituents that are each independently halo, C 1-6 alkyl, C 1-6 alkyloxy, cyano, amino, mono-or di(C 1-4 alkyl)amino.