Patent ID: 6030644
Filing Date: 2000-02-29
Classification: A61K,Y10S

Abstract:
A process for the production of medicinal sustained-release granular preparations comprising a medicinal ingredient solid at room temperature in a matrix of polymer and a plasticizer for the polymer which process comprises the steps of(1) preparing a suspension of the plasticizer in water,(2) admixing and wet granulating an initially dry mixture of fine particulate polymer, having an average particle size not greater than 50 .mu.m, and the medicinal ingredient in the form of a powder by adding the amount of the suspension produced in step (1) to the mixture of polymer and medicinal agent, to obtain granules in which the mixture of the polymer and the plasticizer has a melt film-forming temperature (MFT) and glass transition temperature (Tg) of not more than 100.degree. C., and(3) treating said granules at a temperature higher than the lower of the MFT and Tg of the polymer-plasticizer mixture to obtain dry granular preparations.