Patent ID: 7135187
Filing Date: 2006-11-14
Classification: A01K,A61K,C12N

Abstract:
1. A helper adenovirus nucleic acid sequence comprising a packaging signal, an inserted endonuclease recognition site, a first adenoviral inverted terminal repeat (ITR) located at one end of, and a second adenoviral ITR located at the other end of, the nucleic acid sequence, and a third adenoviral ITR located between the first and second adenoviral ITRs, wherein: (a) said endonuclease recognition site is for an endonuclease that does not cleave anywhere else in said helper adenovirus nucleic acid sequence, and wherein said endonuclease recognition site is disposed at a location in said helper adenovirus nucleic acid sequence 3′ to said packaging signal; and (b) wherein said third adenoviral ITR is disposed at a location in said helper adenovirus nucleic acid sequence 3′ to said endonuclease recognition site.