Patent ID: 6737424
Filing Date: 2004-05-18
Classification: A61P,C07D

Abstract:
A compound of the formula Ia: wherein:R1 is selected from hydrogen, halo, (C1-C4)alkyl and NO2; R2 is a cycloalkyl moiety of 5-7 carbon atoms, or R2 is a group selected from the formulae R2â€² and R2â€³wherein:R3 is selected from CF3, COOH, (C1-C6)alkylCOOH, (C1-C6)alkyl and (C1-C6)alkylCF3; n is selected from 0, 1 or 2; R4 is selected from (C1-C3)alkyl or (C0-C3)alkylphenyl wherein said phenyl moiety is substituted with 0, 1, 2, 3, 4 or 5 J moieties where J at each occurrence is selected from halogen, (C1-C4)alkyl, NO2, CN, perfluoro(C1-C3)alkyl, OH, CF3, (C2-C4)alkenyl, (C2-C4)alkynyl, Oâ€”(C1-C4)alkyl; R5 is phenyl wherein the phenyl group is substituted with 0, 1, 2, 3, 4 or 5 J moieties where J is as in the definition of R4; R6 is selected from hydrogen and (C1-C3)alkyl; R7 is selected from hydrogen and C(O)(C1-C3)alkyl, and with the proviso that said compound is not 7-chloro-4-hydroxy-2-[1-(N-phenylcarbamoyl)ethyl]-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, 7-chloro-4-hydroxy-2-cyclohexyl-1,2,5,10-tetrahydropryidazino[4,5-b]quinoline-1,10-dione, 7-chloro-4-hydroxy-2-(1-methylbenzyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, 7-chloro-4-hydroxy-2-(1-methylbutyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, 7-chloro-4-hydroxy-2-(1-methyl-2-phenylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, or 7-chloro-4-hydroxy-2-(1,3-dimethylbutyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione.