Patent ID: 6743608
Filing Date: 2004-06-01
Classification: C12P

Abstract:
A process by which one of the two enantiomers of a racemic or enantiomerically enriched substrate of formula (I) is converted to formula (III) by a higher rate than the other enantiomer to give a reaction mixture from which the product mixtures (II) and (III) can be separated, comprising:hydrolyzing one of the two enantiomeric forms of a racemic or enantiomerically enriched ester of the formula (I) by a higher rate than the other by an enzyme to give an ester (II) and an acid (III) both with increased enantiomeric purity in a solvent â€ƒwherein R1 is defined as straight or branched C1-30-alkyl, straight or branched C2-30-alkenyl, straight or branched C2-30-alkynyl, straight or branched C4-30-alkenynyl, each of which is optionally substituted with one or more selected from halogen(s), â€”CF3, â€”CN, â€”OH, â€”SH, â€”COOH, C1-6-alkoxy, C1-6-alkylthio, â€”SCF3, â€”OCF3, â€”CONH2, â€”CSNH2, or â€”NXY, wherein X and Y independently are defined as hydrogen or C1-4-alkyl, or R is optionally substituted with phenyl or phenoxy wherein phenyl or phenoxy is optionally substituted with one or more groups selected from halogen(s), â€”OH, â€”SH, â€”COOH, â€”NXY, â€”CF3, â€”CN, C1-4-alkyl, C1-4-alkoxy, C1-4-alkylthio, â€”SCF, â€”OCF3, â€”CONH2 or â€”CSNH2.