Patent ID: 6677363
Filing Date: 2004-01-13
Classification: A61K,A61P,Y10S

Abstract:
A method for improving or treating ketosis in a mammal in need thereof, which comprises administering to said mammal an effective amount of an insulin sensitizer selected from the group consisting of1) pioglitazone or a salt thereof, 2) a compound of the formula: wherein R4 represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Xa represents a chemical bond, a group of the formula â€”COâ€”, â€”CH(OH)â€”, or â€”NR9â€” where R9 represents hydrogen or an alkyl group that may be substituted; k is an integer of 1 to 3; Ya represents oxygen atom, sulfur atom, â€”SOâ€”, â€”SO2â€”, or â€”NR10â€” where R10 represents hydrogen or an alkyl group that may be substituted; ring Ea represents a benzene ring that may have further 1 to 3 substituents; p is an integer of 1 to 8; R5 represents hydrogen, a hydrocarbon group that may be substituted, or a heterocyclic group that may be substituted; q is an integer of 0 to 6; r is 0 or 1; R8 represents hydroxy, â€”OR11 where R11 represents a hydrocarbon group that may be substituted, or â€”NR12R13 where R12 and R13 are the same or different, and represent hydrogen, a hydrocarbon group that may be substituted, a heterocyclic group that may be substituted, or an acyl group that may be substituted, or R12 and R13 may be combined to form a ring; R6 and R7 are the same or different, and represent hydrogen or a hydrocarbon group that may be substituted, or R6 and R5 may be combined to form a ring; or a salt thereof;3) 5-[[6-(2-fluorobenzyloxy)-2-naphthyl]methyl]-2,4-thiazolidinedione; 4) FK-614; and 5) KRP-297.