Patent ID: 6013856
Filing Date: 2000-01-11
Classification: A61L,Y10S

Abstract:
A terminally sterilized osteogenic device for implantation into a mammal produced by a method comprising the steps of:(a) providing an osteogenic device comprising osteogenic protein 1 (OP-1) in combination with a biocompatible, biodegradable insoluble carrier material defining pores dimensioned to permit infiltration, proliferation, and differentiation of migratory progenitor cells when implanted into the mammal; and(b) exposing the osteogenic device of step (a) to ionizing radiation in an amount sufficient to achieve a sterility assurance factor of 10.sup.-6 thereby to produce a terminally sterilized osteogenic device which is competent to induce endochondral bone formation or articular cartilage formation in the mammal.