Patent ID: 6645964
Filing Date: 2003-11-11
Classification: C07D

Abstract:
Compounds which bind the G-quadruplex structure of the telomers, characterized in that they correspond to the following general formula:nitrogen-containing aromatic ring â€”NR3â€” distribution agent â€”NRâ€²3â€” aromatic ring in whichnitrogen-containing aromatic ring represents: a quinoline optionally substituted with at least one group in which Ra and Rb, which are identical or different, represent a short-chain C1-C4 alkyl, alkoxy radical, a quinoline possessing a nitrogen atom in quaternary form, a benzamidine, or a pyridine the aromatic ring represents a quinoline optionally substituted with at least one group N(Ra) (Rb) in which Ra and Rb, which are identical or different, represent hydrogen, a short-chain C1-C4 alkyl, alkoxy radical, a quinoline possessing a nitrogen atom quaternary form, a benzamidine, a pyridine, a phenyl ring optionally substituted at the meta or para position with a halogen group, C1-C4 alkoxy group, cyano group, carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, guanyl groups, C1-C4 alkylthio groups, amino groups, C1-C4 alkylamino groups, C1-C4 dialkylamino groups for each alkyl group, nitro group, alkylene-amino group or alkenyleneamino group, or a mono- or bi- or tricyclic hetero-cyclic ring comprising 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups, or with alkylene or alkenylene groups R3 and Râ€²3, which are identical or different, represent independently of one another hydrogen or a C1-C4 alkyl radical the distribution agent represents: a triazine group optionally substituted with an alkyl radical having 1 to 4 carbon atoms, a thio, oxy or amino radical which are themselves optionally substituted with one or more short-chain alkyl chains containing 1 to 4 carbon atoms or a halogen atom or one of its saltswith the proviso that the compound is not (a) benzenecarboximidamide,4-[4-chloro-6-(phenylamino)-1,3,5-triazin-2-yl]amino, or (b) 1,3,5-triazine-2,4,6-triamine,N,Nâ€²-bis(4-amino-2-methyl-6-quinolinyl)-trihydrochloride.