Patent ID: 8871794
Filing Date: 2014-10-28
Classification: A61K,A61P

Abstract:
1. A method for promoting enhanced wakefulness of a person subject determined to be in need thereof, comprising the step of: (a) orally administering to the subject a type-2 orexin receptor (OX2R) agonist of formula I: in which: R substituted or unsubstituted alkyl; substituted or unsubstituted cycloalkyl; substituted or unsubstituted alkenyl; adamantyl; substituted or unsubstituted phenyl; a 5- or 6-membered optionally substituted saturated or unsaturated heterocyclic group having from one to three heteroatoms selected from nitrogen, oxygen and sulfur; substituted or unsubstituted benzyl; a saturated or unsaturated fused ring carbocyclic group having from 8 to 10 ring atoms; or CH R substituted or unsubstituted alkyl; substituted or unsubstituted cycloalkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkoxyalkyl; a 5- or 6-membered optionally substituted saturated or unsaturated heterocyclic group having from one to three heteroatoms selected from nitrogen, oxygen and sulfur; —(CH substituted or unsubstituted phenyl; substituted or unsubstituted benzyl; a saturated or unsaturated fused ring carbocyclic group having from 8 to 10 ring atoms; or methylene-1-naphthyl; and R hydrogen; (CH CONR C optionally substituted phenoxy; SO NR COR COOR SO or a pharmaceutically acceptable salt thereof, or prodrug thereof.