Patent ID: 7425639
Filing Date: 2008-09-16
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: wherein: R R R X R wherein A represents an aryl, pyridine, thiophene or furan group; R 5 represents cyano, tetrazol-5-yl, —CO 2 H or —CO 2 R 8 ; R 6 and R 7 independently represent hydrogen, C 1-6 alkyl, —CO 2 H, —CO 2 R 8 , cyano, tetrazol-5-yl, halogen, trifluoromethyl or C 1-6 alkoxy, or when R 6 and R 7 are bonded to adjacent carbon atoms, R 6 and R 7 may, together with the carbon atoms to which they are bonded, form a fused 5- or 6- membered ring optionally having one or two nitrogen, oxygen or sulfur atoms; each R 12 independently represents substituents selected from: C 1-6 alkyl, halogen, trifluoromethyl and C 1-6 alkoxy, and n represents an integer from 0-4; and R comprising hydrolysis of a compound of Formula (IB) or a pharmaceutically acceptable salt thereof: wherein: R R R R wherein A represents an aryl, pyridine, thiophene or furan group; R 5 represents cyano, tetrazol-5-yl or —CO 2 R 8 ; R 6 and R 7 independently represent hydrogen, C 1-6 alkyl, —CO 2 R 8 , cyano, tetrazol-5-yl, halogen, trifluoromethyl, or C 1-6 alkoxy, or when R 6 and R 7 are bonded to adjacent carbon atoms, R 6 and R 7 may, together with the carbon atoms to which they are bonded, form a fused 5- or 6- membered ring optionally having one or two nitrogen, oxygen or sulfur atoms; each R 12 independently represents substituents selected from: C 1-6 alkyl, halogen, trifluoromethyl and C 1-6 alkoxy, and n represents an integer from 0-4; R R