Patent ID: 6171613
Filing Date: 2001-01-09
Classification: A61K,Y10S

Abstract:
A method for encapsulating at least one biologically active compound in a liposome comprisinga) obtaining a liposome, by any conventional means, having the substance encapsulated therein and having at least one first amphipathic lipid having a carbon chain from about 1 to about 12 carbons in the lipid component of the formulation;b) determining the percent amount of the encapsulated compound; andc) substituting said at least one first amphipathic lipid having a carbon chain from about 1 to about 12 carbons in the lipid component of the formulation with at least one second amphipathic lipid with a substantially similar chemical structure having from one to 16 more carbons in a fatty acyl chain of the second lipid;wherein the resulting percent of the compound encapsulated is from about 0.2 to about 85 percent.