Patent ID: 6713635
Filing Date: 2004-03-30
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having a general formula (A), and pharmaceutically acceptable salts thereof, whereinX is â€”CONR5R6 or â€”COOR7 or â€”COâ€”R8 or CN; R1 is alkyl, aryl, heterocycloalkyl, heteroaryl, halogen, hydroxy, amino, nitro or cyano; R2, R3and R4, are the same or different and each is independently hydrogen or halogen, hydroxy, amino, nitro, cyano, acyl, acyloxy, sulfonyl, sulfinyl, alkylamino, carboxy, ester, ether, amido, sulfonic acid, sulfonamide, alkylsulfonyl, arylsulfonyl, alkoxycarbonyl, alkylsulfinyl, arylsulfinyl, alkylthio, arylthio, alkyl, alkoxy, oxyester, oxyamido, aryl, arylamino, aryloxy, heterocycloalkyl, heteroaryl, vinyl; R3 is hydrogen, halogen, hydroxy, amino, nitro, cyano, acyl, acyloxy, sulfonyl, sulfinyl, alkylamino, carboxy, ester, ether, amido, sulfonic acid, sulfonamide, alkylsulfonyl, arylsulfonyl, alkoxycarbonyl, alkylsulfinyl, arylsulfinyl, alkylthio, arylthio, alkyl, alkoxy, oxyester, oxyamido, aryl, arylamino, aryloxy, heterocycloalkyl, heteroaryl, (C2-C5)alkenyl, (C2-C5)alkynyl, azido, phenylsulfonyloxy; R5, R6, R7 are the same or different and each is independently hydrogen, hydroxy, alkyl, aryl, heterocycloalkyl, heteroaryl, alkoxy, aryloxy; and R8 is hydrogen, hydroxy, thiol, halogen, alkyl, aryl, heterocycloalkyl, heteroaryl, alkylthio, arylthio; each alkenyl, azido may independently be optionally substituted by one or more halogen, cyano, thiocyano, azido, alkylthi, cyclopropyl, acyl, phenyl.