Patent ID: 6833456
Filing Date: 2004-12-21
Classification: A61P,C07D

Abstract:
A compound represented by the formula I whereinX is â€”CHâ€”; Y is â€”NHâ€”, â€”Oâ€”, or â€”Sâ€”, R1 is indole substituted at the N position by â€”C(O)NR6R7 or â€”C(O)NHCH2â€”Câ‰¡CH, and is optionally further substituted with 1 to 5 R5 substituents; each R5 is independently selected from halo, cyano, nitro, trifluoromethoxy, trifluoromethyl, azido, â€”C(O)R8, â€”C(O)OR8, â€”OC(O)R8, â€”OC(O)OR8, â€”NR6C(O)R7, â€”C(O)NR6R7, â€”NR6R7, â€”OR9, â€”SO2NR6R7, C1-C6 alkyl, C1-C6 alkylamino, C3-C10 cycloalkyl, â€”(CH2)jO(CH2)qNR6R7, â€”(CH2)tO(CH2)qOR9, â€”(CH2)tOR9,â€”S(O)j(C1-C6 alkyl), â€”(CH2)t(C6-C10 aryl), â€”(CH2)t(5 to 10 membered heterocyclic), â€”C(O)(CH2)t(C6-C10 aryl), â€”(CH2)tO(CH2)j(C8-C10 aryl), â€”(CH2)tO(CH2)q(5 to 10 membered heterocyclic), â€”C(O)(CH2)t(5 to 10 membered heterocyclic), â€”(CH2)jNR7(CH2)qNR6R7, â€”(CH2)jNR7CH2C(O)NR6R7, â€”(CH2)jNR7(CH2)qNR9C(O)R8, â€”(CH2)jNR7(CH2)tO(CH2)qOR9, â€”(CH2)jNR7(CH2)qS(O)j(C1-C6alkyl), â€”(CH2)jNR7(CH2)tR6, â€”SO2(CH2)t(C6-C10 aryl), and â€”SO2(CH2)t(5 to 10 membered heterocyclic), wherein j is an integer from 0 to 2, t is an integer from 0 to 6, q is an integer from 2 to 6, the â€”(CH2)qâ€” and â€”(CH2)tâ€” moieties of the said R5 groups optionally include a carbon-carbon double or triple bond where t is an integer between 2 and 6, and the alkyl, aryl and heterocyclic moieties of the said R5 groups are unsubstituted or substituted with one or more substituents independently selected from halo, cyano, nitro, trifluoromethyl, azido, â€”OH, â€”C(O)R8, â€”C(O)OR8, â€”OC(O)R8, â€”OC(O)OR8, â€”NR6C(O)R7, â€”C(O)NR6R7, â€”(CH2)tNR6R7, C1-C6 alkyl, C3-C10 cycloalkyl, â€”(CH2)t(C6-C10 aryl), â€”(CH2)t(5 to 10 membered heterocyclic), â€”(CH2)tO(CH2)qOR9, and â€”(CH2)tOR9, wherein t is an integer from 0 to 6 and q is an integer from 2 to 6; each R6 and R7 is independently selected from H, OH, C1-C6 alkyl, C3-C10 cycloalkyl, â€”(CH2)t(C6-C10 aryl), â€”(CH2)t(5 to 10 membered heterocyclic), â€”(CH2)tO(CH2)qOR9, â€”(CH2)tCN(CH2)tOR9, â€”(CH2)tCN(CH2)tR9 and â€”(CH2)tOR9, wherein t is an integer from 0 to 6 and q is an integer from 2 to 6, and the alkyl, aryl and heterocyclic moieties of the said R6 and R7 groups are unsubstituted or substituted with one or more substituents independently selected from hydroxy, halo, cyano, nitro, trifluoromethyl, azido, â€”C(O)R8, â€”C(O)OR8, â€”CO(O)R8, â€”OC(O)OR8, â€”NR9C(O)R10, â€”C(O)NR9R10, â€”NR9R10, C1-C6 alkyl, â€”(CH2)t(C6-C10 aryl), â€”(CH2)t(5 to 10 membered heterocyclic), â€”(CH2)tO(CH2)qOR9, and â€”(CH2)tOR9, wherein t is an integer from 0 to 6 and q is an integer from 2 to 6, where when R6 and R7 are both attached to the same nitrogen, then R6 and R7 are not both bonded to the nitrogen directly through an oxygen; each R8 is independently selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, â€”(CH2)t(C6-C10 aryl), and â€”(CH2)t(5 to 10 membered heterocyclic), wherein t is an integer from 0 to 6; each R9 and R10 is independently selected from H, â€”OR6, C1-C6 alkyl, and C3-C10 cycloalkyl; and, R11 is â€”C(O)NR12R13, (CH2)t(5 to 10 membered heterocyclic), â€”(CH2)tNR12R13, or â€”SO2NR12R13 wherein the heterocyclic is thiazolyl, imidazolyl, or pyrrolidinyl, and is optionally substituted by one or more R5 groups; each R12 and R13 is independently selected from H, C1-C6 alkyl, C3-C10 cycloalkyl, â€”(CH2)t(C3-C10 cycloalkyl), â€”(CH2)t(C6-C10 aryl), â€”(CH2)t(5 to 10 membered heterocyclic), â€”(CH2)tO(CH2)qOR9, and â€”(CH2)tOR9, q is an integer from 2 to 6, and the alkyl, aryl and heterocyclic moieties of the said R12 and R13 groups are unsubstituted or substituted with one or more substituents independently selected from R5, or R12 and R13 are taken together with the nitrogen to which they are attached to form a pyrrolidinyl, ring, wherein said pyrrolidinyl, rings are unsubstituted or substituted with one or more R5 substituents and wherein t is an integer from 0 to 6 or pharmaceutically acceptable salts or solvates of said compounds.