Patent ID: 8901286
Filing Date: 2014-12-02
Classification: C07H,C12N,C12Q,G01N

Abstract:
1. An isolated cDNA encoding a DOT1L polypeptide, said cDNA selected from the group consisting of: (a) a cDNA comprising SEQ ID NO:1; (b) a cDNA comprising the nucleotide sequence that encodes the DOT1L polypeptide of SEQ ID NO:2; (c) a cDNA that differs from the nucleotide sequence of (a) due to the degeneracy of the genetic code; (d) a cDNA consisting of a fragment of SEQ ID NO:1, wherein said fragment consists of a nucleotide sequence that encodes amino acids 1 to 416 of SEQ ID NO:2; (e) a cDNA consisting of a nucleotide sequence that has at least 95% sequence similarity to the cDNA of (d), wherein said cDNA encodes a polypeptide having H3-K79 methyltransferase activity; and (f) a cDNA consisting of a nucleotide sequence that differs from the nucleotide sequence of (d) due to the degeneracy of the genetic code, wherein said cDNA encodes a polypeptide having H3-K79 methyltransferase activity.