Patent ID: 6613932
Filing Date: 2003-09-02
Classification: A61P,C07C

Abstract:
A prostaglandin derivative represented by the formula: [wherein X is CH2, O or a group represented by the formula: S(O)q1 (wherein q1 is an integer of 0 to 2),Y is an ethylene group, a vinylene group, an ethynylene group or a group represented by the formula: O(CH2)t1 or S(O)q2(CH2)t1 (wherein q2 is an integer of 0 to 2, and t1 is an integer of 1 to 3), Z is an ethylene group, a vinylene group or an ethynylene group, R1 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, R2 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-5 alkyl group, a hydroxy-C1-5 alkyl group, a halogeno-C1-5 alkyl group, a C1-5 alkoxy-C1-5 alkyl group, a C2-4 alkoxycarbonyl-C1-5 alkyl group, a carboxyl-C1-5 alkyl group, a cyano-C1-5 alkyl group, a C1-5 alkyl group substituted with a group represented by the formula: â€”NR7R8 (wherein R7 and R8 are the same or different, and each a hydrogen atom or a C1-5 alkyl group, or R7 and R8 together with the nitrogen atom to which they are attached form a pyrrolidino group, a piperidino group, a piperazino group, a morpholino group or a thiomorpholino group), an acyl group, a group represented by the formula: â€”(CH2)t2CH(NH2)COOR9 (wherein R9 is a hydrogen atom or a C1-5 alkyl group, t2 is 1 or 2) or a group represented by the formula: (wherein R4 and R5 are the same or different, and each a hydrogen atom, a hydroxyl group, a halogen atom, a C1-10 alkyl group, a C1-10 alkoxy group, a C2-10 alkenyl group, a C2-10 alkynyl group, a hydroxy-C1-5 alkyl group, a halogeno-C1-5 alkyl group, a C1-5 alkoxy-C1-5 alkyl group, a C2-4 alkoxycarbonyl group, a carboxyl group, an acyl group, a nitro group, an amino group or an amino group which is mono- or di-substituted with C1-5 alkyl group(s), and r is an integer of 0 to 3),R3 is a hydrogen atom, a C1-10 alkyl group, a C3-10 cycloalkyl group, a C1-5 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-5 alkyl group, a C2-10 alkenyl group or a C2-10 alkynyl group, m is an integer of 0 to 3, n is an integer of 1 to 3, p is an integer of 0 to 5, and q is an integer of 0 to 2], a pharmaceutically acceptable salt thereof or a hydrate thereof.