Patent ID: 7820680
Filing Date: 2010-10-26
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: R R or alternatively R R R each HetA is independently a C each HetB is independently a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein the heteroaromatic ring is optionally substituted with from 1 to 4 substituents each of which is independently halo, —C each aryl is independently phenyl, indenyl, indanyl, naphthyl, or tetrahydronaphthyl; each bicyclic carbocycle is independently a bridged or fused two-ring system containing from 7 to 11 carbons, in which each ring is either saturated or unsaturated, but neither ring is aromatic; each tricyclic carbocycle is independently a bridged or fused or bridged and fused three-ring system containing from 8 to 12 carbons, in which each ring is either saturated or unsaturated, but no ring is aromatic; each heteroaryl is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S or (ii) a 8- or 12-membered bicyclic, fused ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein one or both of the rings in the ring system contain at least one heteroatom, at least one ring is aromatic, and any S atom in a ring which is not aromatic is optionally present in the form of a monoxide or dioxide; each heteromonocycle is independently a 4- to 7-membered saturated or mono-unsaturated heterocyclic ring containing at least one carbon atom and from 1 to 4 heteroatoms independently selected from N, O and S; each bicyclic heterocycle is independently a 7- to 11-membered bridged or fused two-ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, in which each ring is either saturated or unsaturated, but neither ring is aromatic, and one or both rings in the ring system contain at least one heteroatom; each tricyclic heterocycle is independently an 8- to 12-membered bridged or fused or bridged and fused three-ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, in which each ring is either saturated or unsaturated, but no ring is an aromatic, and one or two or all three of the rings contain at least one heteroatom; each R each R each R each R each R each R