Patent ID: 6583283
Filing Date: 2003-06-24
Classification: A61P,C07D

Abstract:
A process for producing a crystalline polymorph of 1,3-di-cyclopropylmethyl-8-amino xanthine, Form I, which process comprisesa) dissolving 1,3-di-cyclopropylmethyl-8-amino xanthine in 1-propanol or in a 1-propanol:water admixture; and b) cooling the solution to crystallize out of solution the desired polymorphic Form I, as characterized in any one of FIGS. 1, 4, 20, or wherein Form I exhibits a single crystal X-ray crystallographic analysis with (a) crystal parameters that are approximately equal to the following: Crystal shape (mm)Flat needlesCrystal dimensions1.0 Ã— 0.12 Ã— 0.08 mmCrystal colorColorlessSpace GroupP1 triclinic #2Temperature295 KCell Constantsa = 10.829(2)Ã¥b = 12.636(2)Ã¥c = 5.105(3)Ã¥alpha (&agr;) = 99.48(4)beta (&bgr;) = 91.53(4)gamma (&ggr;) = 83.84(3)Volume685.0(8)Ã¥3Molecules/unit cell (Z)4Density, (&rgr;) g/cm=31.354&mgr;7.362 cmâˆ’1F(000)292â€ƒthe atomic positions of all atoms relative to the origin of the unit cell as represented in the tables of FIGS. 12 to 15.