Patent ID: 6203803
Filing Date: 2001-03-20
Classification: A61K,A61Q,Y10S

Abstract:
A topically applicable cosmetic composition which is adapted for use in a cosmetic regimen that comprises topical application of said composition to at least one of the skin, hair, or mucous membranes, which composition comprises:(1) an amount of at least one irritant substance sufficient to elicit an irritant side effect to a user having capsaicin-sensitive skin when utilized in a topical cosmetic regimen that does not include the use of a substance P antagonist, wherein said irritant substance is an active agent in said topical cosmetic regimen;(2) an amount of at least one substance P antagonist sufficient to prevent or alleviate said irritation when said composition is utilized in a topical cosmetic regimen on a user having capsaicin-sensitive skin, wherein said substance P antagonist is a substance which possesses at least one of the following characteristics:(i) it elicits a pharmacological response in at least one of the following tests:(a) it reduces the extravasation of plasma through the vascular wall caused by capsaicin or antidromic nerve excitation; and(b) it inhibits the contraction of smooth muscle induced by substance P; and(3) a cosmetically acceptable medium.