Patent ID: 6306439
Filing Date: 2001-10-23
Classification: A61K,A61P

Abstract:
A pharmacologically active composition in a physical form imparting a prolonged gastric residence time, said physical form being selected from the group consisting of tablets, capsules, granules and pellets, said composition comprising:(I) at least one pharmacologically active compound,(II) at least one pharmacologically acceptable auxiliary,(III) polyvinylpyrrolidone,(IV) a carboxymethyl cellulose polymer having an acidic number between 100 and 1,200 mg of KOH/g of polyrmr solid substance, and(V) optionally a gas-forming additive,the polymers (III) and (IV) being present in the form of a homogeneous mixture on the molecular level, the mixture being present in 30-90% by weight of the composition, the weight ratio of (III):(IV) ranging from 80:20 to 95:5, andthe composition in dry compressed state being able to absorb many times its weight of acidic water thereby to form a highly swollen gel of high mechanical and dimensional stability capable of improved prolonged release of the pharmacologically active compound.