Patent ID: 8927723
Filing Date: 2015-01-06
Classification: A01N,C07D

Abstract:
1. A process for making ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-((3-isobutyryloxy)azetidin-1-yl)-4-oxo-1,4-di hydroquinoline-3-carboxylate, or a salt thereof, comprising: (a) reacting ethyl (2E/Z)-3-((6-amino-3,5-difluoropyridin-2-yl)amino)-2-(2,4,5-trifluorobenzoyl) -2-propenoate, or a salt thereof, lithium chloride and 1,8-diazabicyclo[5.4.0]undec-7-ene and not isolating the product; (b) reacting the product of step (a), 3-azetidinol hydrochloride and 1,8-diazabicyclo[5.4.0]undec-7-ene and not isolating the product; and (c) reacting the product of step (b) and isobutyric anhydride and isolating or not isolating the product.