Patent ID: 6444677
Filing Date: 2002-09-03
Classification: A61P,C07D

Abstract:
A compound of the formula (I): or the pharmaceutically acceptable salts thereof whereinA is independently halo; Y1 is â€”(CH2)mâ€”, C(O) or S(O); Y2 is N or CH; R1 and R2 are independently C1-4 alkyl; R3 is selected from the following: (a) â€”(CH2)pâ€”C3-7 cycloalkyl, the cycloalkyl moiety being optionally substituted with one, two or three substituents selected from cyano, amino-C1-4 alkyl-, C1-4 alkylamino-C1-4 alkyl-, C1-3 alkyl-carbonylamino-C1-4 alkyl-, C1-4 alkylsulfonylamino-C1-4 alkyl, amino, 2-oxopyrrolidinyl, C4-7 cycloalkylamino-C1-4 alkyl, di-C1-4 alkylamino-C1-4 alkyl-, hydroxyl, carbamoyl, C1-3 alkylcarbonyl(C1-4 alkyl)amino, C1-4 alkylcarbonyl(C1-4 alkyl)amino-C1-4 alkyl, di-C1-4 alkylamino, pyrrolidinyl-C1-4 alkyl, 2-oxopyrrolidinyl-C1-4 alkyl and di-C1-4 alkylamino-C1-4 alkyl; (b) â€”C5-7 alkyl optionally substituted with one or two substituents selected from 2-oxopyrrolidinyl, C1-3 alkylsuflonylamino, cyano, C1-3 alkylcarbonylamino, 1,1-dioxoisothiazolinyl, 2-oxo-1,3-oxazolidinyl, amino, C1-4 alkylamino, morpholinylcarbonyl, morpholino, C1-3alkyl-2-oxopyrrolidinyl, piperidinyl and 2-oxo-piperidinyl; (c) â€”C1-4 alkyl substituted with one or two substituents selected from 2-oxopyrrolidinyl, C1-3 alkylsuflonylamino, cyano, C1-3 alkylcarbonylamino, 1,1-dioxoisothiazolinyl, 2-oxo-1,3-oxazolidinyl, morpholino, C1-3alkyl-2-oxopyrrolidinyl, piperidinyl and 2-oxo-piperidinyl; and (d) C7-9 bicycloalkyl optionally substitued with di-C1-4 alkylamino and oxopyrrolidinyl; R4 is thiazolyl, imidazolyl or oxazolyl, the thiazolyl, imidazolyl or oxazolyl being optionally substituted with one or two substituents independently selected from C1-4 alkyl and halo; X is S, â€”NH, â€”Nâ€”C1-4 alkyl or 0; R5 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl or halo; m is 0, 1 or 2; n is 0, 1, 2, 3, 4 or 5; and p is 0, 1, 2, 3, 4, 5 or 6.