Patent ID: 7229756
Filing Date: 2007-06-12
Classification: C12Q

Abstract:
1. A method of establishing an alpha-2B-adrenergic receptor function comprising: a. obtaining an isolated polynucleotide that encodes said alpha-2B-adrenergic receptor, or a complement thereof, or a fragment thereof, or a complement of said fragment, that includes nucleotides 901 to 909 of SEQ ID NO: 1, or nucleotides 901 to 909 of SEQ ID NO: 2, or their complements; b. detecting in said isolated polynucleotide the presence or absence of a deletion polymorphism, said deletion polymorphism exclusively consisting of the deletion of nucleotide positions 901 to 909 of SEQ ID NO: 1; and c. establishing that the agonist-mediated receptor function of decreasing adenylyl cyclase activity of said alpha-2B-adrenergic receptor is reduced if said deletion polymorphism is present as compared to said agonist-mediated receptor function if said deletion polymorphism is absent.