Patent ID: 6127369
Filing Date: 2000-10-03
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR30## wherein: X represents nitrogen, carbon or CH,Y represents nitrogen, when X represents carbon, or CH, or Y represents carbon, or CH when X represents nitrogen it being understood that when X or Y represents carbon, then this carbon is substituted by R.sub.2,R.sub.1 represents linear or branched (C.sub.1 -C.sub.6)alkyl (optionally substituted by one or more, identical or different groups, selected from halogen, linear or branched (C.sub.1 -C.sub.6)-alkylthio, linear or branched (C.sub.1 -C.sub.6)alkoxy, monoalkyl- or dialkyl-amino wherein alkyl in each case is linear or branched and has 1 to 6 carbon atoms, aryl, hydroxy, formyl, linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl, and carboxy), it being understood that the two R.sub.1 have either identical definitions or different definitions,R.sub.2 and R.sub.3, which may be identical or different, each independently of the other represents Z, or one of R.sub.2 and R.sub.3 represents W and the other of R.sub.2 and R.sub.3 represents Z in whichZ represents:hydrogen,halogenlinear or branched (C.sub.1 -C.sub.6)alkyl, which alkyl may be substituted by one or more, identical or different groups, selected from hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, aryl, amino (optionally substituted by one or two, identical or different groups, selected from linear or branched (C.sub.1 -C.sub.6)alkyl, aryl, aryl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched, aminoalkyl in which alkyl is linear or branched and has 1 to 6 carbon atoms monoalkylaminoalkyl in which each alkyl is linear or branched and has 1 to 6 carbon atoms dialkylaminoalkyl in which each alkyl is linear or branched and has 1 to 6 carbon atoms linear or branched (C.sub.1 -C.sub.6)-hydroxyalkyl, and alkoxyalkyl in which each alkyl is linear or branched and has 1 to 6 carbon atoms, and formyl,amino (optionally substituted by one or two, identical or different groups, selected from linear or branched (C.sub.1 -C.sub.6)alkyl, aryl, aryl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched, linear or branched (C.sub.1 -C.sub.6)-alkylsulphonyl, arylsulphonyl, aminoalkyl in which alkyl is linear or branched and has 1 to 6 carbon atoms monoalkylaminoalkyl in which each alkyl is linear or branched and has 1 to 6 atoms dialkylaminoalkyl in which each alkyl is linear or branched and has 1 to 6 atoms linear or branched (C.sub.1 -C.sub.6)-hydroxyalkyl, and alkoxyalkyl in which each alkyl is linear or branched and has 1 to 6 carbon atoms),nitro,linear or branched (C.sub.1 -C.sub.6)alkylthio,formyl,hydroxycarbonyl,linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl,aminocarbonyl, monoalkylaminocarbonyl in which alkyl is linear or branched and has 1 to 6 carbon atoms, or dialkylaminocarbonyl in which each alkyl is linear or branched and has 1 to 6 carbon atoms,W represents linear or branched (C.sub.5 -C.sub.24)alkylene, in which one to four carbon atoms are optionally replaced by one to four, identical or different groups, each independently of the other selected from oxygen, imine, --N(R.sub.4)--CO--, --CO--N(R.sub.4)--, and N(R.sub.4) wherein R.sub.4 represents hydrogen or linear branched (C.sub.1 -C.sub.6)alkyl, which alkylene is substituted in its terminal position by one of the following groups: ##STR31## wherein X, Y and R.sub.1 are as defined above, and R.sub.2a, and R.sub.3a represent Z as defined above,their isomers and pharmaceutically-acceptable acid or base addition salts thereof.