Patent ID: 7794755
Filing Date: 2010-09-14
Classification: A61K,C08F,Y10T

Abstract:
1. A process for making a microsphere preparation, comprising: a) forming a first solution comprising: b) forming a second solution comprising at least one substantially chlorinated hydrocarbon of less than 6 carbon units, provided that the chlorinated hydrocarbon is not a halogenated aromatic hydrocarbon, and an organic soluble protecting colloid; c) forming a first suspension with agitation comprising the first and second solutions at a temperature below the initiation temperature of the azo initiator of (a); d) increasing the temperature of the agitating first suspension to a temperature at which the low temperature aqueous soluble azo initiator is activated; e) agitating the first suspension until it forms a second suspension comprising a gelatinous precipitate suspended in an organic liquid phase, wherein microspheres are formed; f) allowing the second suspension to cool to a temperature that is at about 30° C. or below 30° C. while agitating the second suspension; g) washing the second suspension at least once with a dehydrating solvent wherein water is removed from the microspheres forming a microsphere preparation; and h) recovering the microsphere preparation.