Patent ID: 6314316
Filing Date: 2001-11-06
Classification: A61N

Abstract:
A device for manipulating a molecule in vivo relative to a target tissue comprising:a support comprising a generally cylindrical post having a portal therethrough from a top end to a bottom end and at least two discrete electrodes extending away from and affixed to the support in spaced-apart relation from each other, each electrode being in circuit communication with a respective portion of a source of electrical energy;a disc affixed to the post bottom end, the disc having a bottom surface having an outer downwardly depending annulus comprising alternating sectors of conductive and nonconductive areas, the electrodes comprising the conductive sectors; andleads in circuit communication with the conductive areas and extending from the disc through the post portal to the top end thereof;the electrodes being configured to establish a first electromagnetic field between selected electrodes sufficient to manipulate a molecule relative to a target tissue and a second electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue;the device being configured so that at least two of the electrodes are locatable against a selected portion of the target tissue.