Patent ID: 6548651
Filing Date: 2003-04-15
Classification: A61K,A61L,C12N

Abstract:
A modified PNA molecule comprising:H-KFFKFFKFFK-ado-TTC AAA CAT AGT-NH2,H-FFKFFKFFK-GGC-smcc-ado-TTC AAA CAT AGT-NH2,H-FFRFFRFFR-GGC-smcc-ado-TTC AAA CAT AGT-NH2,H-LLKLLKLLK-GGC-smcc-ado-TTC AAA CAT AGT-NH2,H-LLRLLRLLR-GGC-smcc-ado-TTC AAA CAT AGT-NH2,H-LLKKLAKALK-GC-smcc-ado-TTC AAA CAT AGT-NH2,H-KRRWPWWPWKK-C-smcc-ado-TTC AAA CAT AGT-NH2,H-KFKVKFVVKK-GC-smcc-ado-TTC AAA CAT AGT-NH2,H-LLKLLLKLLLK-C-smcc-ado-TTC AAA CAT AGT-NH2,H-FFKFFKFFK-GGC-smcc-ado-TTC AAA CAT AGT-NH2,H-KFFKFFKFFK-C-smcc-ado-TTC AAA CAT AGT-NH2,H-ado-TTC AAA CAT AGT-NH2,H2N-KFFKVKFVVKK-C-smcc-ado-TTC AAA CAT AGT-NH2,H2N-KKFKVKFVVKKC-achc-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-&bgr;.ala-TCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-mbs-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-emcs-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-smph-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-amas-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-smpb-ado-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-gly-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-&bgr;.ala-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-&bgr;.cypr-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-aha-TTCAAACATAGT-NH2,H2N-KKFKVKFVVKKC-lcsmcc-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-ado-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-Gly-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-aha-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-&bgr;.ala-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-p-TTCAAACATAGT-NH2,H-KFFKFFKFFK-P-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-K-K-TTCAAACATAGT-NH2,H-KFFKFFKFFK-F-F-TTCAAACATAGT-NH2,H-KFFKFFKFFK-F-K-TTCAAACATAGT-NH2,H-KFFKFFKFFK-K-F-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-&bgr;.ala-TTCAAACATAGT-NH2,H-KFFKFFKFFK-phg-achc-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-ado-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-Gly-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-P-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-aha-TTCAAACATAGT-NH2,H-KFFKFFKFFK-achc-&bgr;.ala-TTCAAACATAGT-NH2 orH-KFFKFFKFFK-achc-achc-TTCAAACATAGT-NH2.