Patent ID: 9186332
Filing Date: 2015-11-17
Classification: A61J,A61K,A61P

Abstract:
1. A method of administering a glucocorticosteroid active substance selected from prednisone, prednisolone, and methylprednisolone to a patient in need thereof comprising administering to the patient an oral dosage form comprising a defined core and a compression coating completely covering the core, wherein the core comprises the glucocorticosteroid active substance, wherein the compression coating comprises at least one material chosen from fatty acids or their esters or salts; long chain fatty alcohols; polyoxyethylene alkyl ethers; polyoxyethylene stearates; sugar esters; lauroyl macrogol-32 glyceryl; and stearoyl macrogol-32 glyceryl and further provided that the compression coating contains substantially no natural or synthetic gum; wherein the compression coating lacks ingredients that swell and gel to such an extent that the compression coating acts as a diffusion barrier to the release of the active substance, and wherein the compression coating is sufficiently porous to permit the ingress of aqueous media to the core at a rate to ensure release of the glucocorticosteroid active substance after a period of time between 2 to 6 hours wherein said period of time is followed by rupture of the compression coating.