Patent ID: 7462459
Filing Date: 2008-12-09
Classification: A61K

Abstract:
1. A method of screening an agent, conjugate or conjugate moiety for capacity to be transported through the blood brain barrier, comprising: (a) providing a cell expressing a LAT1 transporter, wherein: (b) contacting the cell with an agent, conjugate or conjugate moiety in vitro; and (c) determining whether the agent, conjugate or conjugate moiety passes through the plasma membrane via the LAT1 transporter, passage through the plasma membrane via the LAT1 transporter indicating the agent, conjugate or conjugate moiety has capacity to be transported through the blood brain barrier, wherein: if step (b) comprises contacting the cell with the agent, the agent is a neuropharmaceutical agent or an imaging component; if step (b) comprises contacting the cell with the conjugate, the conjugate comprises an agent that is a neuropharmaceutical agent or an imaging component; or if step (b) comprises contacting the cells with the conjugate moiety, the method further comprises linking the conjugate moiety to an agent that is a neuropharmaceutical agent or an imaging component.