Patent ID: 6046047
Filing Date: 2000-04-04
Classification: A01K,A61K,C07D,C07F,C07H,C07K,C12N,C12P

Abstract:
A genetic construct encoding a chimeric protein which comprises:(a) a ligand-binding domain which binds to a selected ligand to form a ligand cross-linked protein complex including the chimeric protein, wherein the ligand has one or more of the following characteristics:(i) the ligand is not a protein,(ii) the ligand has a molecular weight less than 5 kD, and(iii) the ligand is membrane permeable; and(b) an intracellular targeting domain which is heterologous with respect to the ligand binding domain and, as a result of formation of the ligand cross-linked protein complex, causes cellular localization of said ligand cross-linked protein complex.