Patent ID: 6194421
Filing Date: 2001-02-27
Classification: A61K,A61P,Y02A

Abstract:
A method for treating a patient infected with a metazoan parasite, said method comprising administering a composition comprising a suitable carrier or excipient and an amount effective to kill the parasite of at least one metazoan protease inhibitor of formulaA--X--Bwherein A is a substituted or unsubstituted heteroaromatic ring system selected from the group consisting of pyridyl, indolyl, quinolyl, isoquinolyl, coumarinyl, and phthalazinyl comprising one or two rings which binds to at least one of the S2, S1 and S1' subsites;B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1', S1 and S2 subsites;wherein the substituent on A or B is selected from the group consisting of hydroxyl, lower alkyl, lower alkoxy, amino, mono- and di-(lower alkyl)-amino, --NO.sub.2, halogen, aryl, aryloxy, --COOH and COOR', wherein R' is lower alkyl or aryl; andX is --C.dbd.C--C(.dbd.O)--.