Patent ID: 6406713
Filing Date: 2002-06-18
Classification: A61K,G03B,Y10T

Abstract:
A method of preparing a drug-lipid complex comprising the steps of:(a) dissolving a lipid which comprises a fatty acid or a phospholipid in an organic solvent selected from the group consisting of chloroform, methanol, dimethylsulfoxide (DMSO), methylene chloride, chloroform:methanol mixtures and benzene:methanol mixtures; (b) dissolving a polyene antifungal agent in an organic solvent; (c) combining the product of step (a) and the product of step (b) so as to obtain a mixture of the lipid solution and the agent solution; (d) adding an aqueous phase to the product of step (c); and, (e) removing organic solvent from the mixture of step (c), wherein the complex has no captured volume, wherein the complex is substantially free of liposomes and wherein the relative amount of polyene antifungal agent used is such that the agent comprises from about 25 to 50 mole percent of the complex.