Patent ID: 6448285
Filing Date: 2002-09-10
Classification: A61K,A61P,A61Q,C07D

Abstract:
An indolecarboxylic derivative having formula (Iâ€²): in whichYâ€² represents a hydrogen atom or a radical â€”Oâ€”CHRâ€²3Râ€²4, in which Râ€²3 is a hydrogen atom or an optionally substituted phenyl radical or alternatively a 5- or 6-membered heterocycle and Râ€²4 is an optionally substituted phenyl radical or alternatively a 5- or 6-membered heterocycle, or Râ€²3 and Râ€²4 taken together form, with the carbon atom, a 5- or 6-membered ring or heterocycle; Xâ€² represents a radical â€”Oâ€”CHRâ€²3Râ€²4, in which Râ€²3 is a hydrogen atom or an optionally substituted phenyl radical or alternatively a 5- or 6-membered heterocycle and Râ€²4 is an optionally substituted phenyl radical or alternatively a 5- or 6-membered heterocycle, or Râ€²3 and Râ€²4 taken together form, with the carbon atom, a 5- or 6-membered ring or heterocycle; or, Xâ€² and Yâ€² taken together, form, with the 2 carbon atoms bearing them, a ring or a heterocycle containing 5 or 6 carbon atoms; Z represents a hydrogen atom or a radical â€”Oâ€”Râ€²5 in which R5 is a C1-C6, alkyl radical or a C6-C12, aralkyl radical; Râ€²1 represents a hydrogen atom or a C1-C6, alkyl radical or a C6-C12 aralkyl radical, which is optionally substitutedâ€²; Râ€²2 represents a hydrogen atom or a C1-C6 alkyl radical or a radical â€”CH Râ€²3 Râ€²4 in which Râ€²3 and Râ€²4 have the above definitions; or the esters thereof or the optical isomers thereof, alone or as a mixture in all proportions, the acylated forms thereof or alternatively the pharmaceutically acceptable salts thereof, it being understood: that when Xâ€² is an â€”Oâ€”CH2phenyl radical, then Yâ€² and Zâ€² must not be a hydrogen atom; when Râ€²1=Râ€²2&boxH;Z=H, then Xâ€² and Yâ€² taken together must not form, with the two carbon atoms bearing them, a 5- or 6-membered ring; when Râ€²2&boxH;Z=H, and Xâ€² and Yâ€² taken together form a phenyl ring, Râ€²1 must not be a hydrogen atom or a CH3 radical; when Râ€²1&boxH;Râ€²2=Yâ€²=H, and Xâ€²=â€”OCH2-phenyl radical, then Zâ€² must not be a OCH3 radical; (Iâ€²) is not 3H-pyrrolo-quinoline-2-carboxylic acid; (Iâ€²) is not 2,3-dihydro-7H-1,4-dioxino-2,3-elindole-8-carboxylic acid.