Patent ID: 6051705
Filing Date: 2000-04-18
Classification: A61K,C07D,C07K,Y02P

Abstract:
A process for the preparation of a 6-aminothiazolo(3,2-a)azepine derivative comprising the step of electrolytically oxidizing a pipecolic acid derivative represented by the general formula (2): ##STR66## wherein R.sup.3, R.sup.4 and R.sup.5 each independently represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group, an aryl group which may be substituted or a heteroaryl group which may be substituted; R.sup.11 represents a protecting group of a carboxylic acid; and Z represents an acyl group, to give a hemiacetal represented by the general formula (3): ##STR67## R.sup.3, R.sup.4, R.sup.5 and R.sup.11 having the meanings as described above; and wherein R.sup.12 represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms.