Patent ID: 8404656
Filing Date: 2013-03-26
Classification: A61P,C12N

Abstract:
1. A method of treating or preventing diet-induced obesity and/or one or more sequelae thereof in a subject, the method comprising administering to a subject in need of treatment or at risk for developing diet-induced obesity and/or one or more sequelae thereof, a therapeutically effective amount of a pharmaceutical composition comprising at least one inhibitor of RP105 expression and/or MD-1 expression, wherein the at least one inhibitor of RP105 and/or MD-1 expression is at least one shRNA or siRNA, or a precursor thereof, and wherein the at least one precursor comprises a sequence selected from the group consisting of CCTCTTGGTCTCCAGAGTCAGGCATTCAA (SEQ ID NO: 1); CTACCTCAATCTGGCTGCCAACAGCATTA (SEQ ID NO: 2); CATCAACCTAAGCCTGAACTTCAATGGCA (SEQ ID NO: 3); and GCAGGAACACCGCTTCTCTGACATCTCAT (SEQ ID NO: 4).