Patent ID: 7482454
Filing Date: 2009-01-27
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound according to the steps shown in Scheme I: wherein B1 and P are protecting groups; and n is 1-3; wherein the resulting compound is a compound according to Formula (I): wherein: (a) X is selected from the group consisting of (b) R1 is selected from the group consisting of C (c) R3 is hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C (e) R6 is hydrogen; (f) R8 is unsubstituted methoxy, methylthio, or C (g) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C (h) each R9 is independently selected from the group consisting of hydrogen, C (i) a R7 moiety described in (g) and a R9 moiety described in (h) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to about 5 ring carbons and 0 or 1 ring nitrogen; or an optical isomer, diastereomer or enantiomer thereof; or a pharmaceutically-acceptable salt, thereof.