Patent ID: 6254860
Filing Date: 2001-07-03
Classification: A61K,A61P

Abstract:
A method for enhancing or restoring lacrimal gland tearing in an eye, the method comprising administering topically to the eye, in a pharmaceutically acceptable excipient, a methyl thio-substituted or other alkyl thio-substituted cyclosporin A derivative selected from the group consisting of compounds represented by the general formulas: ##STR2## ##STR3##wherein Me is methyl; Alk is 2-6C alkylene or 3-6C cycloalkylene; R is OH, COOH, alkoxycarbonyl, --NR.sub.1 R.sub.2 or --N (R.sub.3)--(CH.sub.2).sub.n --NR.sub.1 R.sub.2 ; wherein R.sub.1, R.sub.2 is H, alkyl, 3-6C cycloalkyl, phenyl (optionally substituted by halo, alkoxy, alkoxycarbonyl, amino, alkylamino or dialkylamino), benzyl or saturated or unsaturated heterocyclyl having 5 or 6 members and 1-3 heteroatoms; or NR.sub.1 R.sub.2 is a 5 or 6 membered heterocycle which may contain a further N, O or S heteroatom and may be alkylated; R.sub.3 is H or alkyl and n is 2-4; and alkyl moieties contain 1-4C.