Patent ID: 6034057
Filing Date: 2000-03-07
Classification: A61K,A61P,C07K

Abstract:
A cyclic dimeric peptide of formula 1 ##STR43## wherein peptide 1 and peptide 2 independently represent a tetrapeptide of formula-AA1-AA2-AA3-AA4- juxtaposed in parallel or antiparallel orientation; andAA1 is an L or D amino acid selected from Ile, Leu, Pro, Gly, Tic, Gln, and Phe;AA2 is an L amino acid selected from Leu, Ile, Phe, Pro and Val;AA3 is an L amino acid selected from Asp and Glu;AA4 is an L amino acid selected from Val, Leu, Ile, Phe, Ser. Pro and Cha;L1 and L2 independently represent linking moieties for linking peptides 1 and 2 to form a cyclic peptide; or a salt thereof, whereinAA1 to AA4 each have the general formula 2 ##STR44## wherein R.sup.1 is the amino acid side chain and R.sup.2 and R.sup.3 are independently selected from H and C.sub.1-4 alkyl.