Patent ID: 8834848
Filing Date: 2014-09-16
Classification: A61K,A61M,Y10S

Abstract:
1. A drug and device combination system for the treatment of a patient suffering from oral corticosteroid-dependent asthma, said combination comprising: an inhalable corticosteroid formulation; and an electronically controlled inhalation device adapted to administer the inhalable corticosteroid formulation to the patient as an aerosol predominantly into the small airways of the lower lungs of the patient; the inhalation device being further adapted to generate the aerosol as a bolus with a mean particle size from about 1 μm to about 5 μm at a controlled flow rate preset to be from 100 ml/second to 400 ml/second; the inhalation device being further adapted to administer the aerosol with an overpressure of 0.1 mbar to 40 mbar; and the inhalation device being further adapted to administer the aerosol in two or three phases wherein a first phase is optional and consists of administering particle-free air to the patient, wherein said first phase is followed by a second phase consisting of administration of the aerosol comprising the corticosteroid to the patient, and wherein said second phase is followed by a third phase consisting of administration of particle-free air to the patient; and wherein such administration of the inhalable corticosteroid formulation results in: complete or partial weaning of the patient from the orally administered corticosteroids and an increase of the FEV1-values of the patient.