Patent ID: 6040339
Filing Date: 2000-03-21
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I): ##STR19## wherein: R.sup.1 represents an alkyl group having from 1 to 12 carbon atoms;R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each represents:a hydrogen atom;an alkyl group having from 1 to 12 carbon atoms;an alkyl group which has from 1 to 4 carbon atoms and which is substituted by from 1 to 5 fluorine atoms;an alkyl group which has from 1 to 12 carbon atoms and which is substituted by an unprotected or protected hydroxy group;a group of formula --(C.dbd.O)--B.sup.1wherein B.sup.1 represents a hydrogen atom, an alkyl group having from 1 to 12 carbon atoms, a group of formula --O--D,wherein D represents a hydrogen atom or a carboxy-protecting group,a group of formula --NR.sup.a R.sup.b,wherein R.sup.a and R.sup.b are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 12 carbon atoms,a nitro group;a group of formula --NR.sup.c R.sup.d,wherein R.sup.c represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.d represents an alkyl group having from 1 to 4 carbon atoms;a hydroxy group or a protected hydroxy group;an alkoxy group having from 1 to 10 carbon atoms;a group of formula --O--B.sup.2 --(C.dbd.O)--B.sup.1,wherein B.sup.1 is as defined above and B.sup.2 represents an alkylene group having from 1 to 5 carbon atoms;a group of formula --O--B.sup.2 --B.sup.3,wherein B.sup.2 is as defined above and B.sup.3 represents an alkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms, an alkylsulfinyl group having from 1 to 6 carbon atoms, an alkylsulfonyl group having from 1 to 6 carbon atoms or an alkylsulfonylarmino group having from 1 to 6 carbon atoms;a cyano group;a group of formula --CH.dbd.N--OB.sup.4,wherein B.sup.4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;an alkylthio group having from 1 to 6 carbon atoms;an alkylsulfinyl group having from 1 to 6 carbon atoms;an alkylsulfonyl group having from 1 to 6 carbon atoms;an alkylsulfonylamino group having from 1 to 6 carbon atoms;a group of formula --SO.sub.2 NR.sup.e R.sup.f,wherein R.sup.e represents a hydrogen atom or an alkyl group which has from 1 to 6 carbon atoms and R.sup.f represents an alkyl group which has from 1 to 6 carbon atoms;or a halogen atom; orR.sup.2a and R.sup.2b are adjacent to each other and together represent a group of formula--O--(CH.sub.2).sub.m --O--wherein m is an integer of from 1 to 3;R.sup.3 represents an alkyl group having from 1 to 6 carbon atoms;R.sup.4 represents a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR20## wherein: A.sup.1 represents a single bond, an alkylene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;A.sup.2 represents an alkyene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;A.sup.3 represents a single bond, an alkylene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;R.sup.5a and R.sup.5b are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a group of formula --A.sup.4 R.sup.5c,wherein A.sup.4 represents a single bond, an alkylene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;R.sup.5c represents an alkoxy group having from 1 to 4 carbon atoms;R.sup.6 represents an alkyl group having from 1 to 4 carbon atoms or a phenyl group which is substituted or unsubstituted;R.sup.7 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;R.sup.8 represents an alkyl group having from 1 to 12 carbon atoms, an alkyl group having from 1 to 12 carbon atoms substituted by an unprotected or protected carboxy group, an alkyl group having from 1 to 12 carbon atoms substituted by from 1 to 5 fluorine atoms, an alkoxy group having from 1 to 10 carbon atoms, an aralkoxy group in which an alkoxy group having from 1 to 4 carbon atoms is substituted by a carbocyclic aryl group having from 6 to 10 ring carbon atoms, a phenyl group which is substituted or unsubstituted;R.sup.9 and R.sup.10 are the same or different and each represents an alkyl group having from 1 to 4 carbon atoms;or a ortho-phenylene group; andn represents 0;or pharmaceutically acceptable salts thereof.