Patent ID: 8022046
Filing Date: 2011-09-20
Classification: A61P,C12N

Abstract:
1. A method of treating or reversing type-1 diabetes in a mammal comprising administering a composition comprising microspheres in an amount effective to treat or reverse type-1 diabetes, said microspheres comprising oligonucleotides that are antisense to and targeted to bind to primary transcripts selected from the group consisting of CD40, CD80 and CD86 primary transcripts, said oligonucleotides individually comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and modified forms of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7 which target and bind CD40, CD80 and CD86 primary transcripts.