Patent ID: 8883307
Filing Date: 2014-11-11
Classification: A23L,A61K,C07H,C13B,Y10T

Abstract:
1. A powder consisting essentially of spherical particles of crystalline mannitol having an aspect ratio of 1.0 to 1.2, an oil absorption rate 1 of 25 to 60% and an oil absorption rate 2 of 15 to 40% according to test method A, wherein the powder has a mean particle diameter of 15 to 165 μm and a loose bulk density of 0.35 to 0.60 g/mL, wherein the test method A comprises: adding 30 g of middle chain fatty acid triglyceride and 15 g of the powder, (together referred to hereinafter as “the sample”) to a 100 ml glass beaker; stirring the sample with a spatula gently enough to avoid crushing of fine particles; introducing the sample into a vacuum constant temperature dryer for three hours at a room temperature at a pressure reduced down to 0.67 pascals; pouring the sample into a centrifuge tube having openings at bottom with a filter cloth of 325 meshes laid inside; centrifuging the centrifuge tube containing the sample by a centrifuge for 10 minutes at about 1300 G; obtaining the weight, in grams, of the powder remaining in the centrifuge tube after centrifugation (W placing the centrifuge tube containing the powder remaining after centrifugation into another 100 ml glass beaker and adding 20 g of n-hexane onto the powder, centrifuging the centrifuge tube for 10 minutes at about 1300 G; obtaining the weight, in grams, of the powder remaining in the centrifuge tube after the second centrifugation (W wherein the oil absorption rate 1 and the oil absorption rate 2 are given the following formulas: