Patent ID: 6492366
Filing Date: 2002-12-10
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:R1 and R2 each independently represent hydrogen, or linear or branched (C1-C6)alkyl, T1 and T2 each independently represent linear or branched (C1-C6)alkylene, G represents a heterocyclic group selected from those of formula (&agr;): â€ƒwherein: W1 to W5 and X1 to X4 are defined as follows: W1, W2 and W3 each independently represent nitrogen, CR5, NR4, or CO, W4 represents nitrogen, CR3, NR4 or CO, W5 represents carbon or nitrogen, X1 represents a bond, or CR3, X2 to X4 each independently represent CR3, NR4, CO, SR4, SO2 oxygen, sulphur, or nitrogen, R3 represents hydrogen, halogen, linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)perhaloalkyl, nitro, or amino optionally substituted by one or two groups selected from linear or branched (C1-C6)alkyl, benzyl, R4 represents hydrogen, linear or branched (C1-C6)alkyl, optionally substituted aryl, or optionally substituted arylalkyl, R5 represents R3, or two adjacent groups R5 form, together with the carbon atoms carrying them, a saturated, partially unsaturated or unsaturated mono- or bi-cyclic group optionally containing 1 to 5 hetero atoms selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more groups selected from R3 or oxo, â€ƒit being understood that, in formulae (&agr;) and (&bgr;), at least one heteroatom is present, the dotted lines indicate that the groups in question may contain an unsaturated bond or a plurality of conjugated or unconjugated unsaturated bonds and that, if there is no unsaturated bond, the remaining valences are occupied by hydrogen atoms, the groups (&agr;) and (&bgr;) being linked to T2 by any one of their ring junctions, its enantiomers, diastereoisomers, or addition salts thereof with a pharmaceutically-acceptable acid or base.