Patent ID: 8948852
Filing Date: 2015-02-03
Classification: A61B,G01N

Abstract:
1. A real time Diffusive Optical Tomographic (DOT) imaging system for imaging of a biological tissue of a subject comprising: (a) an excitation light source for directing excitation light waves from the excitation light source into the biological tissue to cause an administered fluorescent imaging probe in the three-dimensional target region to emit fluorescent light, wherein the biological tissue of the subject has a volume V bounded by boundary S, and wherein the volume V is of arbitrary geometry; (b) a detector for detecting an intensity of the fluorescent light and the excitation light waves emitted from multiple points from the biological tissue by using non-contact measurements of the excitation light waves and the fluorescent light outside the biological tissue, where there is air between the detector and biological tissue; and (c) a computer processor for processing the detected intensity of fluorescent light and the detected intensity of the excitation light waves to generate a tomographic image indicating the quantity of fluorescent imaging probe in the three-dimensional target region within the subject; wherein the computer processor generates the tomographic image by modeling propagation of diffuse photon waves inside the volume V taking into account the boundary surface S and a modeling of the intensities at the detector located outside the biological tissue of the subject.