Patent ID: 8946200
Filing Date: 2015-02-03
Classification: A61K

Abstract:
1. A method for preparing a nanoparticulate suspension of a pharmaceutically active compound comprising: combining a pharmaceutically active compound in a solvent to provide a solution of said pharmaceutically active compound at a concentration of 0.001 mg to 1.99 mg to 0.5 ml and wherein said solvent is an organic solvent having a pKa≧7.0; introducing said solution of said pharmaceutically active compound into an aqueous buffered solution and forming said nanoparticulate suspension of said pharmaceutically active compound by precipitation and without mechanical shearing under ambient conditions; wherein said suspension has a level of surfactant that is less than or equal to 1.0 ppm; and wherein said solvent consists essentially of an organic alcohol having the following structure: wherein one or more R groups are fluorine atoms and wherein the remaining R groups are independently selected from the group consisting of a hydrogen atom and an alkyl group.