Patent ID: 7667052
Filing Date: 2010-02-23
Classification: A61K,A61P,C07D,C12P

Abstract:
1. A compound represented by the formula (1) or a pharmacologically acceptable salt thereof: wherein in the formula (1), n represents an integer of 3 to 12; and R 2 , R 3a , R 3b , R 4 , R 5a , R 5b , R 6a , R 6b , R 7a , R 7b , R 8 , R 9a , R 9b , R 10 , R na and R nb are the same as or different from each other and each means (1) hydrogen, (2) hydroxy or (3) <1> methyl, <2> C 1-22 alkoxy, <3> ArCH 2 O— (wherein Ar represents C 6-14 aryl or 5-membered to 14-membered heteroaryl, each of which may have substituents), <4> C 2-22 acyloxy, <5> unsaturated C 3-22 acyloxy, <6> R CO COO— (wherein R CO represents C 6-14 aryl, 5-membered to 14-membered heteroaryl, C 1-22 alkoxy, unsaturated C 2-22 alkoxy, C 6-14 aryloxy or 5-membered to 14-membered heteroaryloxy, each of which may have substituents), <7> C 1-22 alkylsulfonyloxy, <8> benzenesulfonyloxy or <9> R s1 R s2 R s3 SiO— (wherein R s1 , R s2 and R s3 are the same as or different from each other and each represents methyl, ethyl, i-propyl, t-butyl or phenyl), each of which may have substituents, (4) halogen or (5) R N1 R N2 N—R M — (wherein R M represents a single bond or —CO—O—; and R N1 and R N2 are 1) the same as or different from each other and each represents <1> hydrogen or <2> (i) C 1-22 alkyl, (ii) unsaturated C 3-22 alkyl, (iii) C 2-22 acyl, (iv) unsaturated C 3-22 acyl, (v) C 6-14 aryl, (vi) 5-membered to 14-membered heteroaryl, (vii) benzyl, (viii) C 1-22 alkylsulfonyl or (ix) benzenesulfonyl, each of which may have substituents, or 2) —NR N1 R N2 may be bound together to represent 3-membered to 14-membered nitrogen-containing non-aromatic heterocyclic ring which may have substituents); further, R 2 may form a single bond with either of R 3a or R 3b to represent the partial structure further, R 3a and R 3b may be bound together to represent a ketone structure (═O) or an oxime structure {═NOR OX (wherein R OX represents C 1-22 alkyl, unsaturated C 3-22 alkyl, C 6-14 aryl, 5-membered to 14-membered heteroaryl or benzyl, each of which may have substituents)}; further, either of R 3a or R 3b and either of R 6a or R 6b may be bound with oxygen to represent the partial structure further, R 4 may form a single bond with either of R 5a or R 5b and may represent the partial structure further, R 5a and R 5b may be bound together to represent a ketone structure (═O) or an oxime structure (═NOR OX ); further, R 6a and R 6b may be bound together to represent a spirooxyrane ring or exomethylene; further, either of R 6a or R 6b and either of R 7a or R 7b may be bound together to form a 1,3-dioxolane ring; further, R 7a and R 7b may be bound together to represent a ketone structure (═O) or an oxime structure (═NOR OX ); further, R 8 may form a single bond with either of R 9a or R 9b to represent the partial structure further, R 9a and R 9b may be bound together to represent a ketone structure (═O) or an oxime structure (═NOR OX ); further, two adjacent R na s may form 0 to 3 ethylene structures where one R na and one other R na form a single bond; further, two R na s may form 0 to 2 epoxy structures together with oxygen; further two R na s may form one 2-oxo-1,3-dioxane structure; further, R na and R nb on the same carbon may be bound together to represent a ketone structure (═O) or an oxime structure (═NOR OX ), provided that (Restricted clause 1) when the above-mentioned compound is represented by the following formula (2): at least one of R (Restricted clause 2) when the above-mentioned compound is represented by the following formula (3): R (Restricted clause 3) a compound represented by the formula (4) is excluded: and (Restricted clause 4) a compound, wherein R