Patent ID: 8138376
Filing Date: 2012-03-20
Classification: C07C

Abstract:
1. A process for preparing (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethyl-pentanamine, or an acid addition salt thereof, comprising the steps of a) acylating (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl-3-pentanol  with an acylating agent; b) hydrogenolysis of the thus obtained compound (III)  using a transition metal catalyst in a reaction-inert organic solvent in the presence of hydrogen; and c) optionally converting the thus obtained (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine  into an acid addition salt.