Patent ID: 7611857
Filing Date: 2009-11-03
Classification: A01K,A61K,C07K,C12N,G01N,Y10S

Abstract:
1. A method for identifying a modulator of IL-17 receptor-like polypeptide activity comprising: (a) exposing a cell to a test compound, wherein the cell is transformed or transfected with a polynucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of: b) detecting IL-17 receptor-like polypeptide activity in said cell by measuring induction of expression of TNF-α, IL-1 α, or IL-6, and (c) comparing said activity of IL-17 receptor-like polypeptide in the presence and absence of the test compound, wherein an increase in said IL-17 receptor-like polypeptide activity indicates the candidate modulator is a stimulator of IL-17 receptor-like polypeptide and wherein a decrease in said IL-17 receptor-like polypeptide activity indicates the test compound is an inhibitor of IL-17 receptor-like polypeptide activity.