Patent ID: 6783931
Filing Date: 2004-08-31
Classification: A61K,C07H,C07J,C12N,C12Q,C12Y

Abstract:
A compound comprising a plurality of linked nucleosides, wherein:each nucleoside includes a pentofuranosyl sugar portion and a base portion; and at least one of said nucleosides bears at a 2â€²-O-position, a 3â€²-O-position, or a 5â€²-O-position of said pentofuranosyl sugar a terminal substituent having formula: â€”RAâ€”N(R1a)(R1b) where:RA is alkyl having from 1 to about 10 carbon atoms or (CH2â€”CH2â€”Q)x; R1a and R1b, independently, are H, R2, or an amine protecting group or have formula C(X)â€”R2, C(X)â€”RAâ€”R2, C(X)â€”Qâ€”RAâ€”R2, C(X)â€”Qâ€”R2; and R2 is a folate, a steroid molecule, a reporter molecule, a lipophilic molecule, a reporter enzyme, a peptide, a protein, or has formula â€”Qâ€”(CH2CH2â€”Qâ€”)xâ€”R3; X is O or S; each Q is, independently, is NH, O, or S; x is about 1 to about 50; R3 is H, RA, C(O)OH, C(O)ORA, C(O)R4, RAâ€”N3, or RAâ€”NH2; R4 is Cl, Br, I, SO2R5 or has structure: m is 2 to 7; and R5 alkyl having 1 to about 10 carbon atoms.