Patent ID: 6620829
Filing Date: 2003-09-16
Classification: A61K,A61P

Abstract:
A method of treating noninflammatory cartilage damage in a mammal suffering therefrom, comprising administering a therapeutically effective amount of a GABA analog having the characteristic of being an inhibitor of cartilage damage, wherein the GABA analog is a compound of Formula: or a pharmaceutically acceptable salt thereof wherein: n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; R1 to R14 are each independently selected from hydrogen or straight or branched alkyl of from 1 to 6 carbons, unsubstituted or substituted benzyl or phenyl which substituents are selected from halogen, alkyl, alkoxy, hydroxy, carboxy, carboalkoxy, trifluoromethyl, and nitro; Aâ€² is a bridged ring selected from: â€ƒwherein â€ƒis the point of attachment; Z1 to Z4 are each independently selected from hydrogen and methyl; o is an integer of from 1 to 4; and p is an integer of from 0 to 2 with the proviso that in formula 1 R is not â€”SO3H when m is 2 and n is 1.