Patent ID: 6596718
Filing Date: 2003-07-22
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR is selected from the group hydrogen, â€”(CH2)n-phenyl, said â€”(CH2)n-phenyl being unsubstituted or substituted by a substituent selected from the group halogen, lower alkyl, lower alkoxy, trifluoromethyl and â€”N(Râ€²)â€”C(O)-lower alkyl, â€”(CH2)n-pyridinyl, said â€”(CH2)n-pyridinyl being unsubstituted or substituted by lower alkyl, â€”(CH2)nâ€”C3-6-cycloalkyl, said â€”(CH2)nâ€”C3-6-cycloalkyl cycloalkyl being unsubstituted or substituted by hydroxy, â€”(CH2)nâ€”N(Râ€²)â€”C3-6-cycloalkyl, said â€”(CH2)nâ€”N(Râ€²)â€”C3-6-cycloalkyl being unsubstituted or substituted by hydroxy, â€”(CH2)n-benzo[1,3]-dioxolyl, â€”(CRâ€²2)n-thiophenyl, said â€”(CRâ€²2)n-thiophenyl being unsubstituted or substituted by lower alkyl, â€”(CRâ€²2)n-thiazolyl, said â€”(CRâ€²2)n-thiazolyl being unsubstituted or substituted by lower alkyl, â€”(CH2)nâ€”C(O)-thiophenyl, said â€”(CH2)nâ€”C(O)-thiophenyl being unsubstituted or substituted by halogen, â€”(CH2)n-furanyl, said â€”(CH2)n-furanyl being unsubstituted or substituted by lower alkyl, â€”(CH2)nâ€”C(O)â€”(CH2)n-thiophenyl, â€”(CHRâ€²)n-benzofuran-2-yl, â€”(CH2)n-benzo[b]thiophenyl, said â€”(CH2)n-benzo[b]thiophenyl being unsubstituted or substituted by lower alkyl, â€”(CH2)nâ€”N(Râ€²)â€”C(O)-phenyl, said â€”(CH2)nâ€”N(Râ€²)â€”C(O)-phenyl being unsubstituted or substituted by halogen or lower alkoxy, â€”(CH2)nâ€”C(O)-phenyl, said â€”(CH2)â€”C(O)-phenyl being unsubstituted or substituted by lower alkoxy, â€”(CH2)nâ€”C(O)-2,3-dihydro-benzo[1,4]dioxin-6-yl, â€”(CH2)nâ€”N(Râ€²)â€”C(O)-pyridinyl, â€”(CH2)n-tetrahydrofuranyl, â€”CH-bi-phenyl, â€”CH(phenyl)-pyridinyl, â€”(CH2)n-1-oxo-1,3-dihydro-isoindol-2-yl, â€”(CH2)n-1,3-dioxo-1,3-dihydro-isoindol-2-yl, â€”(CH2)nâ€”CH(phenyl)-tetrahydropyranyl, â€”(CH2)n-1-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl or â€”(CH2)nâ€”S-[1,3,4]thiazol-2-yl, said â€”(CH2)nâ€”S-[1,3,4]thiazol-2-yl being unsubstituted or substituted by amino; Râ€² is independently selected from hydrogen and lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable acid addition salt thereof.