Patent ID: 6503910
Filing Date: 2003-01-07
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I)(B)2Nâ€”Xâ€”(CH2)nâ€”CR1R2â€”COâ€”Yâ€ƒâ€ƒ(I) whereinn=0-2; X is S(O)1-2; Y is OH or NHOH; CR1R2 is a cycloalkyl ring substituted with a group selected from &boxH;O, &boxH;CR3R4 or &boxH;NOR3, or CR1R2 is dioxaspirodecane optionally substituted with R3 or R5; R3 is H or a group (optionally substituted with R5) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, hetercycloalkyl or C1-6 alkyl-heterocycloalkyl; R4 is H or C1-6 alkyl; R5 is OR9, OCF3, OCH2F, OCHF2, COR9, CO2R4, CON(R9)2, N(R9)2, NR9COR9, NR9CON(R9)2, NR9CO2R10, NR9SO2R10, S(O)0-2R10, SO2N(R9)2 or cycloimidyl (optionally substituted with R6); R6 is C1-6 alkyl; (B)2N is a piperazine optionally substituted with a group selected from R7, &boxH;CR7R4, &boxH;O or &boxH;NOR7; R7 is H, R8 or a group (optionally substituted with R8) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl; R8 is H or a group selected from N(R9)2, NR9COR9, NR9CON(R9)2, NR9CO2R10, NR9SO2R10, OR9, OCF3, OCH2F, OCHF2, COR9, CO2R4, CON(R9)2, S(O)0-2R10 or SO2N(R9)2; R9 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R10, COR10, SO0-2R10, CO2R10, OR10, OCF3, OCH2F, OCHF2, CONR4R10, NR4R10, or SO2NR4R10 and for each case of N(R9)2 the R9 groups are the same or different, or N(R9)2 is heterocycloalkyl optionally substituted with R10, COR10, SO0-2R10, CO2R10OR10, CONR4R10, NR4R10, or SO2NR4R10, and R10 is C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl; and the salts, solvates, hydrates, N-oxides, protected amino, protected carboxy and protected hydroxamic acid derivatives thereof.