Patent ID: 6673795
Filing Date: 2004-01-06
Classification: A61P,C07D

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof, whereinR1 is selected from the group consisting of nitro and cyano; R2 is selected from the group consisting of hydrogen, (C1-C7)-alkyl and â€”NHR10; wherein R10 is selected from the group consisting of hydrogen, (C1-C7)-alkyl, â€”(CH2)mâ€”OR11, â€”(CH2)pâ€”(C3-C6)-cycloalkyl, â€”(CH2)mâ€”NHâ€”C(O)Oâ€”(C1-C7)-alkyl and â€”(CH2)p-pyridyl; wherein R11 is selected from the group consisting of hydrogen and (C1-C7)-alkyl; R3 is selected from the group consisting of hydrogen, (C1-C7)-alkyl, fluoro, hydroxy, (C1-C7)-alkoxy, (C1-C7)-alkylthio, cyano and nitro; R4 is selected from the group consisting of hydrogen and fluoro; â€ƒis selected from the group consisting of R5 is selected from the group consisting of hydrogen, (C1-C7)-alkyl, (C1-C7)-alkenyl, â€”(CH2)mâ€”OR11, fluoro-(C1-C7)-alkyl and â€”(CH2)nâ€”CN; R6 is selected from the group consisting of (C1-C7)-alkyl, halogen, hydroxy, (C1-C7)-alkoxy, (C1-C7)-alkylthio, â€”Oâ€”(CH2)mOR11, â€”O-fluoro-(C1-C7)-alkyl and â€”NHR12; and R12 is selected from the group consisting of (C1-C7)-alkyl, â€”(CH2)mâ€”OR11, â€”(CH2)pâ€”(C3-C6)-cycloalkyl and â€”(CH2)p-pyridyl; R7 is selected from the group consisting of hydrogen, (C1-C7)-alkyl and phenyl; R8 is selected from the group consisting of hydrogen, (C1-C7)-alkyl and phenyl; Z is selected from the group consisting of R9 is selected from the group consisting of hydrogen, hydroxy and cyano; m is independently from each other in each occurrence 2, 3, 4, 5 or 6; n is independently from each other in each occurrence 1, 2, 3, 4, 5 or 6; and p is independently from each other in each occurrence 0, 1, 2, 3, 4, 5 or 6.