Patent ID: 6207820
Filing Date: 2001-03-27
Classification: A61P,C07H,C40B

Abstract:
A method of synthesizing at least one compound having the formula ##STR38##wherein D represents a monosaccharide or disaccharide, A represents a monosaccharide, and P--R represents a lipophosphoglycerate mimetic group that is not a phospholipid group of moenomycin A or a saturated form thereof, said method comprising the steps of:(a) covalently linking an acceptor monosaccharide (A) to a support by forming a carboxylate or carboxyamide linkage between the C6 carbon of A and the support, with A substituted at its anomeric carbon with a thiophenyl group;(b) covalently linking the anomeric carbon of a donor saccharide (D) via an O-glycosidic linkage to the C2 carbon of A to form a D-A moiety linked to the support;(c) coupling a lipophosphoglycerate mimetic group (P--R) to the anomeric position of the A residue of the D-A moitty to form a D-A-P-R moiety linked to the support; and(d) cleaving the D-A-P-R moiety from the support, thereby affording said at least one compound.