Patent ID: 7094907
Filing Date: 2006-08-22
Classification: B01J,C07B,C07C,C07F

Abstract:
1. A process for the manufacture of compounds of the formulae IA or IIA, wherein Y or substituted moiety selected from the group consisting of aryl, heterocyclyl, cycloalkyl, aryl-lower alkyl, heterocyclyl-lower alkyl, cycloalkyl-lower alkyl, alkyl, aryloxy, heterocyclyloxy, cycloalkyloxy, aryl-lower alkoxy, heterocyclyl-lower alkoxy, cycloalkyl-lower alkoxy and alkoxy; or —N(Q) or one or all of the pairs (i) Z X X X or additionally, for compounds of formula IIA for the ring system attached to Y R, R wherein, for the manufacture of a compound of the formula IA, a compound of the formula IIIA, wherein the moieties have the meanings given above under formulae IA and IIA, is reacted with an organolithium compound to the corresponding ortho-lithiated derivative of the formula IVA, wherein M is lithium, and the other moieties are as defined for compounds of the formulae IIIA; if desired, trans-metallating the compounds with M ═Li into other metallates wherein M is a different metal or a metal halide; and then (a) for the preparation of compounds of the formulae IA a compound of the formula IVA is reacted with a compound of the formula V, wherein Y 2 *, Z 3 * and Z 4 * have the meanings of the corresponding moieties in formulae IA; and L is a leaving group, especially halogen; to the corresponding compound of formula IA*, wherein the moieties have the meanings given for compounds of the formula IA; which compounds fall under the definition of formula IA; and, if desired, a resulting compound of the formula IA is converted into a different compound of formula IA, and/or a mixture of isomers of a compound of the formula IA is separated into the individual isomers; or Image Page 5 (b) for the preparation of a compound of the formula IIA, a compound of the formula IVA, is oxidatively dimerized to a corresponding compound of the formula IIA*, wherein Y 1 * and Y 1 ′*, independently of each other, are P(═S), P(═O) or P, Q, X 1 , X 2 and X 3 have the meanings given for compounds of the formula IIA; which compound falls under the definition of formula IIA; and, if desired, a resulting compound of the formula IIA is converted into a different compound of formula IIA, and/or a mixture of isomers of a compound of the formula IIA is separated into the individual isomers; or (c) for the preparation of a compound of the formula IIA, where X where M* is 1 or Br for a Negishi type coupling or M* is B(R 3 ) 2 , where R 3 is alkyl or OH, for a Suzuki type coupling; to give when reacted with half a mole of compound IVA the corresponding compound of formula IIA*; which compound falls under the definition of formula IIA; and, if desired, a resulting compound of the formula IIA is converted into a different compound of formula IIA, and/or a mixture of isomers of a compound of the formula IIA is separated into the individual isomers.