Patent ID: 6849599
Filing Date: 2005-02-01
Classification: A61K

Abstract:
1. A method of inhibiting tumor cell growth in a mammal, comprising administering to said mammal a composition comprising a thrombospondin polypeptide and an inhibitor of DNA topoisomerase I enzyme activity, wherein said tumor cell is a colon tumor cell, wherein said thrombospondin polypeptide is thrombospondin-1 (TSP-1) or thrombospondin-2 (TSP-2) and said inhibitor of DNA topoisomerase I enzyme activity is irinotecan (CPT-11) and wherein administering the composition produces a synergistic antineoplastic effect in said mammal such that tumor growth is inhibited in the presence of said thrombospondin polypeptide and said water soluble camptothecin compound compared to in the absence of said thrombospondin polypeptide and said water soluble camptothecin compound.