Patent ID: 6645981
Filing Date: 2003-11-11
Classification: A01N,A61P,C07D

Abstract:
A compound having a structure according to Formula (I) wherein: (A) (1) A1 â€”is C(R8)â€”, where R8 is selected from hydrogen, halo, C1 to about C6 alkoxy, C1 to about C6 alkylthio, C1 to about C6 alkyl, C2 to about C6 alkene and alkyne; (2) (a) X is â€”Câ€”, a is a double bond and b is a single bond; and (b) Y is â€”N(R1)â€”; (3) R1 is selected from C3 to about C6 cycloalkyl, C4 to about C6 heterocycloalkyl, C1 to about C6 alkyl, C2 to about C6 alkene, a 6-membered aryl and a 6-membered heteroaryl; (4) R2 is hydrogen; (5) R3 is selected from hydrogen and hydroxy; (6) R5 is selected from hydrogen, hydroxy, amino, halo, C1 to about C6 alkyl, C2 to about C6 alkene-and C1 to about C6 alkoxy; (7) R6 is selected from fluoro and chloro; (8) R7 is â€”Qâ€”C(R11)(R11â€²)(R11â€³), where Q is selected from â€”Sâ€”, â€”Oâ€” and â€”C(R12)(R12â€²)â€”, where R12 and R12â€² are each independently selected from hydrogen and fluoro; where R11, R11â€² and R11â€³ are each independently selected from hydrogen, hydroxy and halo; and where R11 and R12 may also both be nil, such that a double bond is formed between the respective carbon atoms; (9) R9 and R9â€² are each independently selected from hydrogen and C1 to about C15 alkyl, or R9 and R9â€² join to form a heterocyclic ring containing the nitrogen atom to which they are bonded; and (10) R10 represents the moieties on the piperidine ring other than R7 and â€”NR9R9â€², where each R10 is independently selected from hydrogen, C1 to about C6 alkyl and fluoro; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.