Patent ID: 8808516
Filing Date: 2014-08-19
Classification: G01N

Abstract:
1. A method of electrically recording from a cell, the method comprising: contacting a cell membrane with a probe electrode comprising a base region and a post projecting from the base region, the post having a diameter of less than about 2 μm, a distal electrochemically active region, a proximal non-electrochemically active region, and a medial heterofunctional region between the distal electrochemically active region and the proximal non-electrochemically active region, wherein the medial heterofunctional region is more hydrophobic than either the distal electrochemically active region or the proximal non-electrochemically active region; forming a seal with the cell membrane so that the electrochemically active region is in electrical communication with the cell and the medial heterofunctional region is held in the cell membrane; and recording electrical activity with the probe electrode.