Patent ID: 6784298
Filing Date: 2004-08-31
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinR1 is a five- or six-membered aromatic heterocyclic ring having one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which ring is unsubstituted or substituted with halo, amino, hydroxylamino, nitro, cyano, sulfonamido, lower alkyl, perfluoro lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or â€”(R5)nâ€”C(O)â€”OR6; R2 is a cycloalkyl ring containing from 5 to 7 carbon atoms; R3 is an unsubstituted five- or six-membered aromatic heterocyclic ring having one or two heteroatoms selected from nitrogen, oxygen, and sulfur; R4 is hydrogen or lower alkyl; R5 is â€”C(O)â€” or lower alkyl; R6 is lower alkyl; n is 0 or 1; * and * * each designate an asymmetric centers or a pharmaceutically acceptable salt thereof.