Patent ID: 6653330
Filing Date: 2003-11-25
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a pharmacologically acceptable prodrug or salt thereof: wherein:Ar1 is selected from the group consisting of a phenyl group and a phenyl group substituted with 1 to 3 substituents wherein said substituents are selected from the group consisting of a halogen atom and a trifluoromethyl group; Ar2 is selected from the group consisting of a phenylene group, a phenylene group substituted with 1 or 2 substituents wherein aid substituents are selected from the group consisting of a fluorine atom and a chlorine atom, a naphthylene group and a naphthylene group substituted with 1 or 2 substituents wherein said substituents are selected from the group consisting of a fluorine atom and a chlorine atom; X is selected from the group consisting of a sulfur atom and a methylene group; R1 is selected from the group consisting of a hydrogen atom and a C1-3 alkyl group; R2 is selected from the group consisting of a hydrogen atom and a C1-3 alkyl group; R3 is selected from the group consisting of a C6-10 aryl group, a C6-10 aryl group substituted with 1 to 5 substituents selected from substituent group A, a heteroaryl group, a heteroaryl group substituted with 1 or 2 substituents selected from substituent group A, a C7-14 aralkyl group, and a C7-14 aralkyl group substituted with 1 to 5 substituents selected from substituent group A; the substituent group A substituent(s) are selected from the group consisting of a C1-6 alkyl group, a C1-6 alkyl group substituted with 1 to 5 substituents wherein said substituents are selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group and a C1-6 alkoxy group, a C1-6 alkoxy group, a C1-6 alkoxy group substituted with 1 to 5 substituents wherein said substituents are selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group and a C1-6 alkoxy group, a C1-6 alkanoyl group, a C2-6 alkanoyl group substituted with 1 to 5 substituents wherein said substituents are selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group and a C1-6 alkoxy groupe, a C1-6 alkanoyloxy group, a C2-6 alkanoyloxy group substituted with 1 to 5 substituents wherein said substituents are selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group and a C1-6 alkoxy group, a halogen atom, a hydroxyl group, an amino group, a mercapto group, a carbamoyl group, a nitro group, a cyano group, a carboxyl group, a group of formula â€”S(O)nR4 wherein R4 is selected from the group consisting of a C1-6 alkyl group and a C1-6 alkyl group substituted with 1 to 5 substituents wherein said substituents are selected from the group consisting of halogen atoms, and n represents 0, 1, or 2, a C2-6 alkenyl group, a C2-6 alkynyl group, a C3-6 cycloalkyl group, and a (C3-6 cycloalkyl)C1-6 alkyl group.