Patent ID: 6831094
Filing Date: 2004-12-14
Classification: A61P,C07D

Abstract:
A compound of formula I whereinW is SO2, CO, CONH, CSNH or (CH2)x; X is O, SOy or NR13; Y is CR14; Z is CR15; m and x are each independently 0 or an integer of 1,2 or 3; n is an integer of 1, 2 or 3; p is an integer of 1; R1 is halogen, CN, OR16, CO2R17, CONR18R19, CNR20NR21R22, SO2NR23R24, SOwR25, or a C1-C6alkyl, C2-C8alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, phenyl or heteroaryl group each optionally substituted; R2, R3, R5, R6, R7, R8, R9, R10 and R11 are each independently H or an optionally substituted C1-C6alkyl group; R4 is H, CNR26NR27R28 or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R12 is an optionally substituted C1-C6alkyl, aryl or heteroaryl group; y and w are each 0 or an integer of 1 or 2; R13 is H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R14 and R15 are each independently H, halogen or a C1-C6alkyl, aryl, heteroaryl or C1-C6alkoxy group each optionally substituted; R16 is H, COR29 or a C1-C8alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted; R17 and R29 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R18, R19, R20, R21, R22, R26, R27 and R28 are each independently H or an optionally substituted C1-C6alkyl group; R23and R24 are each independently H or a C1-C6alkyl, aryl or heteroaryl group each optionally substituted; and R25 is an optionally substituted C1-C6alkyl, aryl, or heteroaryl group; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.