Patent ID: 6596857
Filing Date: 2003-07-22
Classification: C07F,C07H

Abstract:
An oligomeric compound comprising a moiety having a phosphate linkage of the Formula XXX: wherein:R3 is hydrogen, alkyl, cyanomethyl, monohalomethyl, dihalomethyl, trihalomethyl, â€”CH2Si(R4)3, or â€”CH2â€”SOkR4 where k is 0, 1 or 2; R4 is independently alkyl, aryl, aralkyl or alkaryl having up to 15 carbon atoms; R5 is H, â€”CN, â€”Si(R4)3, SOkR4 or halogen; or R8 and R16 are each H, and R3 and R5, together, form one of the structures â€ƒwherein: R10 and R11 are H, alkyl having from 1 to about 10 carbons, â€”CH2C(&boxH;O)OR22, â€”CH2CN, â€”CH2Si(CH3)3, or o- or p-C6H4â€”R21; R21 is hydrogen, â€”Oâ€”C(&boxH;O)CH3, alkoxy having from 1 to about 10 carbons, â€”NO2, or â€”N(R22)2; R22 is independently H or alkyl having from one to about 10 carbon atoms; p is 1 or 2; Z1 and Z2 are independently halogen, CN, â€”Si(CH3)3, and â€”C(&boxH;O)OR22; R30 is hydrogen, â€”Oâ€”C(&boxH;O)CH3, alkoxy having from 1 to about 10 carbons, or â€”Oâ€”Si(R4)3; R6 is H, alkyl or aralkyl having up to 15 carbon atoms; or R5 and R6, together with the atoms to which they are attached, form a 5 or 6 membered ring; R7 is alkyl or aralkyl having up to 15 carbon atoms; or R6 and R7, together, form one of the structures wherein X, T, and Z are independently CH or NH; or Z and R5, together with the atoms to which they are attached, form a phenyl ring; R8 is H or methyl; R9 is a hydroxyl protecting group or a solid support; R16 is H, alkyl or aralkyl having up to 15 carbon atoms; B is a nucleobase; and n is an integer from 0 to 50.