Patent ID: 6492360
Filing Date: 2002-12-10
Classification: A61P,C07D

Abstract:
A compound of formula wherein is a single or double bond; Z is NH, methylene, a (C2-C6) alkylene chain optionally branched and/or unsaturated and/or interrupted by a (C5-C7) cycloalkyl residue; A is phenyl or heterocycle optionally substituted by one or more substituent(s) selected among oxo, nitro, carboxy groups and halogen atoms, or A is a COR4 group wherein R4 is hydroxy, (C1-C6) alkoxy, amino optionally substituted by one or two (C1-C6) alkyl group(s) or by hydroxy; R is a (C1-C6) alkyl or polyluoro (C1-C6) alkyl group; R1 is absent when  is a double bond or, when  single bond, is a) hydrogen; b) (C1-C6) alkyl optionally substituted by aryl, by heterocycle or by a COR5 group wherein R5 is hydroxy, (C1-C4) alkoxy or hydroxyamino; c) â€”COR6 wherein R6 is hydrogen, aryl, aryl-(C1-C6) alkyl, amino optionally alkylated or monohydroxylated, hydroxy, (C1-C4) alkoxy, carboxy, (C1-C4) alkoxycarbonyl, â€ƒor (C1-C4) alkyl optionally substituted by heterocycle; d) (C1-C4) alkylsulfonyl; R2 represents two hydrogen atoms or a group &boxH;O when  is a single bond, or, when  is a double bond, R2 is hydrogen, cyano, (C1-C4) alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (C1-C8) alkyl, (C2-C8) alkenyl or (C2-C8) alkynyl optionally branched and/or substituted by aryl or heterocycle; aryloxy, heterocyclyloxy, aryl-(C1-C4)-alkoxy, heterocyclyl-(C1-C4) alkoxy, amino substituted by one or two (C1-C4) alkyl group(s), arylamino, heterocyclylamino, aryl-(C1-C4) alkylamino, heterocyclyl-(C1-C4)-alkylamino; R3 is hydrogen, or a (C1-C8) alkyl, (C2-C8) alkenyl or (C2-C8) alkynyl group optionally substituted by hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s) or heterogroup(s); the Nâ†’O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof.