Patent ID: 6326377
Filing Date: 2001-12-04
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR19##wherein:m is 3,n is 0,p is 1 to 6 inclusive,the junction between the B and C rings is in the trans configuration,X represents cyano or --CO--NR.sub.4 R.sub.5, R.sub.4 and R.sub.5 being selected hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, and optionally substituted aryl,A represents a .sigma. bond or a group selected from --NR--CO--, --CO--NR--, NR--SO.sub.2 and SO.sub.2 --NR wherein R represents hydrogen or linear or branched (C.sub.1 -C.sub.6)-alkyl,R.sub.1 and R.sub.2 each independently represent hydrogen or linear or branched (C.sub.1 -C.sub.6)-alkyl,R.sub.3 represents:hydrogen, or phenyl, naphthyl or heteroaryl each of which is optionally substituted by one or more halogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.6)-alkoxy, hydroxy, cyano, amino, nitro, carboxy, linear or branched (C.sub.1 -C.sub.6)-perhaloalkyl, sulpho, acylamino, linear or branched (C.sub.1 -C.sub.6)-alkylsulphonyl or linear or branched (C.sub.1 -C.sub.6)-alkylsulphonylamino,2-indolinon-5-yl,or aryloxy or arylthio (with the proviso that in that case A represents .sigma. bond),their enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.