Patent ID: 6057303
Filing Date: 2000-05-02
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR6## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each individually hydrogen; or --(C.sub.0 -C.sub.6 alkylene, C.sub.1 -C.sub.6 alkenylene or C.sub.2 -C.sub.6 alkynylene)--SiR.sub.12 R.sub.13 R.sub.14, --(C.sub.0 -C.sub.6 alkylene, C.sub.1 -C.sub.6 alkenylene, C.sub.2 -C.sub.6 alkynylene, phenylene or benzylene)--NR.sub.9 R.sub.10, or OR.sub.6, wherein one or more hydrogen atoms of these moieties are optionally substituted by halo, lower alkyl, nitro, amino, substituted amino, hydroxy, lower alkoxy, aryloxy or trihalomethyl groups; wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than hydrogen;R.sub.6 is hydrogen, lower alkyl, or an oxygen-protecting group;R.sub.7 is --(C.sub.0 -C.sub.6 alkylene)--SiR.sub.16 R.sub.17 R.sub.18 ;R.sub.9 and R.sub.10 are each individually hydrogen, lower alkyl or a nitrogen-protecting group;R.sub.11 is carbonyl, sulfonyl, thiocarbonyl or sulfoxo;R.sub.12, R.sub.13, and R.sub.14 are each individually hydrogen or C.sub.1 -C.sub.10 alkyl;R.sub.16, R.sub.17, and R.sub.18 are each individually hydrogen, C.sub.1 -C.sub.16 alkyl, C.sub.1 -C.sub.16 alkenyl, C.sub.1 -C.sub.16 alkynyl, aryl,; ora pharmaceutically acceptable salt thereof.