Patent ID: 6228988
Filing Date: 2001-05-08
Classification: C07K,C08F,Y02P

Abstract:
A process for the preparation of a desired synthetic product having a covalently bonded hydroxamic acid group --CONHOH, wherein the process comprises:(i) forming a mixture of a liquid reaction medium and a solid phase reaction product which carries a plurality of moieties of formula (A1): ##STR28##wherein X represents a residual, non-hydroxamate, partial structure of the desired synthetic product, P.sub.1 represents hydrogen or an amino-protecting group, and the bond designated (a) covalently links the moieties (A1) to a residue of a solid substrate and is cleavable under acid conditions or by photolysis; and(ii) in the resultant mixture, cleaving the bond designated (a) and, if P.sub.1 is not hydrogen, removing that protecting group P.sub.1 before, after or during cleavage of bond (a); and(iii) separating the resultant liquid reaction phase from the resultant reaction solids and recovering the desired synthetic product from the separated liquid reaction phase.