Patent ID: 8633001
Filing Date: 2014-01-21
Classification: C07B,C07C,C07D,C12P

Abstract:
1. A process for producing an optically active succinimide derivative represented by the formula (I): [in the formula (I), R (A) the step of reacting an aminomalonate derivative represented by the formula (II): [in the formula (II), R [in the formula (III), R [in the formula (IV), each of R (B) the step of allowing an enzyme that is a pig liver esterase or a rabbit liver esterase to react on the ester derivative represented by the formula (IV) or a salt thereof for conversion into an optically active carboxylic acid derivative represented by the formula (V): [in the formula (V), each of R (C) the step of reacting the optically active carboxylic acid derivative represented by the formula (V) or a salt thereof with an ammonia source in the presence of a condensing agent, or reacting the optically active carboxylic acid derivative represented by the formula (V) or a salt thereof with an activating reagent and then reacting the resultant with an ammonia source, for conversion into an optically active amide derivative represented by the formula (VI): [in the formula (VI), each of R (D) the step of allowing a base to react on the optically active amide derivative represented by the formula (VI) or a salt thereof for conversion into an optically active succinimide derivative represented by the formula (I) or (VII): [in the formula (VII), R (E) the step of eliminating the protective group on R