Patent ID: 6458784
Filing Date: 2002-10-01
Classification: C07D

Abstract:
A compound according to formula (I): whereinXâ€”Xâ€² is NR1â€”CH, NC(O)R3â€”CH or N&boxH;C; R1 is H, C1-6 alkyl or benzyl; R2 is (CH2)nCO2H; R3 is H, C1-6alkyl, Arâ€”C0-6alkyl, Het-C0-6alkyl, or C3-6cycloalkyl-C0-6alkyl; R4 is Wâ€”U; R6 is H, C1-6alkyl, Arâ€”C0-6alkyl, Het-C0-6alkyl and C3-6cycloalkyl-C0-6alkyl; n is 1 or 2; U is NR1C(O), C(O)NR1, CH&boxH;CH, Câ‰¡C, CH2â€”CH2, Oâ€”CH2, CH2â€”O or CH2OCONR1; W is Ra is H, OH, NO2, N(R6)2, CON(R6)2, CH2N(R6)2, or R6HNâ€”C(&boxH;NH); and pharmaceutically acceptable salts thereof,provided that R3 is not phenylethyl when R4 is (3-amidino)phenylaminocarbonyl and Xâ€”Xâ€² is NHâ€”CH.