Patent ID: 7122628
Filing Date: 2006-10-17
Classification: C07K,Y02P

Abstract:
1. A process for making a peptide of the formula (I), wherein said process comprises: (a) temporarily protecting the indole-NH group on the side chain of any tryptophan residue with a side chain protecting group; (b) temporarily protecting the side chain of the histidine residue with a side chain protecting group; (c) attaching a cesium salt of Boc-Gly onto a chloromethylated polystyrene resin to yield Boc-Gly resin; (d) deblocking Boc-Gly-resin by mixing the Boc-Gly-resin with a mixture of a Boc-deblocking organic acid to yield an organic acid salt of H (e) neutralizing the organic acid salt of H (f) successively coupling H (g) deprotecting the protected indole-NH group on the side chains of the tryptophan residues and cleaving the completed peptide-resin to yield ρGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH (h) isolating ρGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH