Patent ID: 6403579
Filing Date: 2002-06-11
Classification: A61K,A61P

Abstract:
A process for producing a solid dosage form pharmaceutical combination preparation containing carvedilol, or a pharmaceutically acceptable salt thereof, and hydrochlorothiazide, or a pharmaceutically acceptable salt thereof, which comprises:a) forming a press mass containing a carvedilol, or pharmaceutically acceptable salt thereof, granulate and a hydrochlorothiazide carvedilol, or pharmaceutically acceptable salt thereof, granulate, the two granulates each having a granulate moisture content between about 6% and about 20% and a bulk density between about 0.1 g/ml and about 1.5 g/ml, the granuate moisture content and the bulk density of the two granulates not varying from each other by more than about 30%; and b) compressing the press mass to form the solid dosage form pharmaceutical combination preparation.