Patent ID: 6828346
Filing Date: 2004-12-07
Classification: A61K,B82Y

Abstract:
A method for treating a disease associated with undesirable cell proliferation or angiogenesis in a patient suffering therefrom, comprising:providing a water miscible, non-aqueous paclitaxel formulation comprising paclitaxel and ascorbic acid dissolved in a water-miscible non-aqueous solvent and a pharmaceutically-acceptable, water-miscible solubilizer selected from the group consisting of solubilizers having the general structures of R1COOR2, R1CONR2, and R1COR2, wherein R1 is a derivative of d-&agr;-tocopherol and R2 is a hydrophilic moiety;diluting the water miscible, non-aqueous paclitaxel formulation into a pharmaceutically acceptable aqueous solution; and parenterally administering to the patient the pharmaceutically acceptable aqueous solution comprising paclitaxel at a dose of 0.1-50 mg/Kg, wherein the said disease is sensitive to the effects of said non-aqueous paclitaxel formulation.