Patent ID: 6069137
Filing Date: 2000-05-30
Classification: A61K,Y02A,Y10S

Abstract:
A method to treat traveller's diarrhea mediated by enterotoxigenic E. coli in a subject, which method comprises administering to a subject in need of such treatment an effective amount of a composition comprising an oligosaccharide sequence selected from the group consisting of .beta.Gal(1-4).beta.Glc, .beta.Gal(1-3).beta.GalNAc, .beta.GalNAc(1-4).beta.Gal, .beta.Gal(1-3).beta.Gal, .beta.Gal(1-3).beta.GalNAc(1-4).beta.Gal, and .alpha.NeuAc(2-3).beta.Gal covalently attached to derivatized silica particles, wherein said oligosaccharide sequence binds at least one serotype of enterotoxigenic E. coli, and wherein said composition is capable of being eliminated from the gastrointestinal tract.