Patent ID: 6348195
Filing Date: 2002-02-19
Classification: G01N

Abstract:
A method for treating a subject with a cancer, cells of which present antigen LK26 on their surfaces, comprising administering to said subject a therapeutically effective amount of a humanized antibody specific for said LK26 antigen, wherein said humanized antibody comprises a variable region heavy chain and a variable region light chain, wherein said variable region heavy chain comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 18, SEQ ID NO: 19 and SEQ ID NO: 22, and said variable region light chain comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 23 and SEQ ID NO: 25, with the proviso that, in SEQ ID NO: 25, amino acid 72 is Tyr, wherein said humanized antibody is conjugated to a label having a therapeutic property.