Patent ID: 6846953
Filing Date: 2005-01-25
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula I wherein R R X is (CH n is 1, 2 or 3; R wherein R 5 is hydrogen, halogen, C 1 -C 4 alkyl, nitro, N 3 or CF 3 and R 6 is hydrogen, C 1-4 alkyl, — and the pharmaceutically acceptable salts thereof, with the proviso that in formula I: when R 1 is H, (X) n is (CH 2 ) 2 and R 2 and R 3 are both ethyl, R 4 is not benzyl, 4-methylbenzyl, 4-chlorobenzyl, 2-chlorobenzyl, 4-bromobenzyl, 3-ethylbenzyl, 4 isopropylbenzyl, 4-n-propylbenzyl, 3-n-butylbenzyl, 2-t-butylbenzyl, 4-s-butylbenzyl or 2-bromobenzyl; when R 1 is H, (X) n is CH r and R 4 is benzyl, NR 2 R 3 is not NHCH 2 Ph, NH-t-butyl, N(CH 3 ) 2 or N(CH 2 CH 3 ) 2 ; and when R 1 is n-butyl, (X) n is (CH 2 ) 2 and R 4 is benzyl, NR 2 R 3 is not NHCH 2 Ph.