Patent ID: 9044425
Filing Date: 2015-06-02
Classification: A61K,A61P

Abstract:
1. An aqueous ophthalmic composition useful for treating eye diseases, lesions and injuries, comprising at least one peptide comprising N-acetyl-Arg-Gly-Asp-Ser (SEQ ID NO: 2), a pharmaceutically acceptable salt of the peptide or peptidomimetic thereof in topical pharmaceutical formulations used for viscosity-increasing properties, comprising a combination with a compound chosen among a cellulose compound selected from a group consisting of carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylycellulose or another polysaccharide compound related to cellulose compounds, a pharmacologically acceptable salt thereof, mixtures thereof, carboxypolymethylene or polyvinylpyrrolidone in an amount effectively increasing the intraocular absorption of said peptide, a pharmacologically acceptable salt of the peptide or peptidomimetic thereof in the aqueous humor or by an organism upon ophthalmic application of said composition, and wherein said peptide or pharmaceutically acceptable salt or peptidomimetic thereof is present in an amount ranging from 0.1-1.0 mg/ml (0.01 to 0.1%), and wherein said peptide or pharmaceutically acceptable salt or peptidomimetic thereof is administered using the optimal effective concentration in said ophthalmic composition that reduces effectively intraocular pressure on chronic topical ocular administration for the treatment of primary open-angle glaucoma and ocular hypertension.