Patent ID: 8372415
Filing Date: 2013-02-12
Classification: A61K,A61P

Abstract:
1. A method for formulating (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b ][1,4]oxazin-4(3H)-yl)methyl phosphate disodium salt into a formulation for tablet compression, which method comprises: a) blending (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino) -2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl phosphate disodium salt with starch and optionally at least one of a filler, a lubricant, a suspending/dispersing agent, a binding agent and a disintegrant, at an impellor speed sufficient to form a homogenous powder mixture having a bulk density after drying of about 6 kp to about 30 kp; b) spraying into the homogenous powder mixture between about 15% and about 40% by weight of water with respect to the total weight of the powder mixture plus water and mixing to form wet granules; and c) drying the wet granules until a loss on drying of between about 5% and about 11% is achieved, to provide dried granules.