Patent ID: 6124314
Filing Date: 2000-09-26
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating a vertebrate which presents with low bone mass comprising administering to said vertebrate a therapeutically effective amount of a compound of Formula II ##STR10## a prodrug thereof or a pharmaceutically acceptable salt of said compound or said prodrug, wherein:A is ethylene, n-propylene, .alpha.-methylethylene, .beta.-methylethylene, .alpha.,.alpha.-dimethylethylene, .beta.,.beta.-dimethylethylene or oxymethylene;B is N or C(Q);R is carboxy, (C.sub.1 -C.sub.10) alkoxycarbonyl, carbamoyl, mono-N- or di-N,N-(C.sub.1 -C.sub.4)alkyl-substituted carbamoyl or --COOY wherein Y is 1-succinimidoethyl, 1-pivaloyloxyethyl, 2-acetamidoethyl, diloweralkylaminoloweralkyl, or carbazoyl;R.sup.1 is H, methyl, ethyl or propyl;R.sup.2 is H or (C.sub.2 -C.sub.5) alkanoyl;R.sup.3 is independently H or methyl;R.sup.4 is H, (C.sub.1 -C.sub.4) alkyl, vinyl or 2,2,2-trifluoroethyl; or R.sup.4 and R.sup.1 are taken together to form a 5-9 membered carbocyclic ring;R.sup.5, when B is C(Q), is formyl, acetyl, pivaloyl, propionyl, acryloyl, hydroxyacetyl, 3-hydroxypropionyl, hydroxymethyl, 1-hydroxyethyl, 1,2-dihydroxyethyl, 1,3-dihydroxypropyl or 1-hydroxyl-1-methylethyl;R.sup.5, when B is N, is formyl, acetyl, propionyl, acryloyl, hydroxyacetyl, 2,2,2-trifluoroethyl or R.sup.6 SOy;Z is methylene, ethylene, n-propylene, tetramethylene, vinylene or ethynylene;Q is H, chloro, bromo, methyl, phenyl or substituted phenyl;R.sup.6 is methyl, ethyl, propyl or isopropyl; andy is 1 or 2.