Patent ID: 7695921
Filing Date: 2010-04-13
Classification: G01N

Abstract:
1. A method for detecting the presence of prostate cancer in a subject, comprising: a) providing a prostate tumor cell sample from a subject, b) detecting the presence or absence of an increased level of phosphorylated, nuclear IKKα (SEQ ID NO: 8) in said prostate tumor cell sample, relative to the level of phosphorylated, nuclear IKKα (SEQ ID NO: 8) in a normal cell sample, wherein an increased level of phosphorylated, nuclear IKKα (SEQ ID NO: 8) in said prostate tumor sample indicates the presence of a cancer selected from the group consisting of prostate carcinoma and metastatic prostate cancer, and the absence of phosphorylated, nuclear IKKα (SEQ ID NO: 8) in said prostate tumor cell sample indicates benign prostatic hyperplasia, and c) detecting the presence or absence of a reduced level of Maspin (SEQ ID NO: 10) in said prostate tumor cell sample relative to the level of Maspin (SEQ ID NO: 10) in a normal cell sample, wherein a reduced level of Maspin (SEQ ID NO: 10) in said prostate tumor sample indicates the presence of a cancer selected from the group consisting of prostate cancer and metastatic prostate cancer.