Patent ID: 6429023
Filing Date: 2002-08-06
Classification: G01N

Abstract:
A waveguide sensing device for detecting or measuring the amount of analyte present in a sample, wherein said device comprises:(a) a sensor arm comprising a site for sample addition that has been modified with an analyte binding partner, and having a first end in optical communication with a second end; (b) a modulator arm comprising a site for application of an electric field and having a first end in optical communication with a second end; (c) a means for applying an electric field to said modulator arm; (d) an input port connected to said first end of each of said sensor arm and said modulator arm, that provides a means for directing an optical signal to each of said first ends; and (e) an output port connected to said second end of each of said sensor arm and said modulator arm, that provides a means for combining the optical signal received from each of said second ends and directing the combined signal to a detector, wherein said modulator arm and sensor arm are each comprised of an optical nonlinear second-order polymer.