Patent ID: 8491927
Filing Date: 2013-07-23
Classification: A61K,A61P

Abstract:
1. A transdermal patch for induction therapy used with a monoclonal antibody treatment, the patch comprising: a first reservoir for containing a first component; a first microporous membrane in fluid communication with the first reservoir, the first membrane having a first porosity; a second reservoir for containing a second component; a second microporous membrane in fluid communication with the first reservoir, the second membrane having a second porosity; wherein the first component comprises a DNA and histone hypomethylating agent in a first transdermal composition and the second component comprises a histone deacetylase inhibitor (HDACi) in a second transdermal composition; wherein the first porosity and the first transdermal composition are selected to transfer an effective amount of the DNA and histone hypomethylating agent across the first membrane over a first desired period of time, and the second porosity and the second transdermal composition are selected to transfer an effective amount of the HDACi across the second membrane over a second desired period of time; wherein the first and second microporous membranes define a plurality of holes having a diameter of about 0.05 to about 10 micrometers, to form the first and second porosities; and wherein the transdermal patch delivers 5-20 mg/m