Patent ID: 8278479
Filing Date: 2012-10-02
Classification: C07B,C07C

Abstract:
1. A method for producing an optically active, fluorine-containing, carbonyl-ene product represented by formula [3] wherein Rf represents a perfluoroalkyl group, R represents an alkyl group, each of R * represents an asymmetric carbon but is not an asymmetric carbon in case that R wave line represents an E configuration or Z configuration in geometrical configuration of the double bond, the method comprising reacting a fluorine-containing α-ketoester represented by formula [1] wherein Rf and R respectively represent the same substituents as above, with an alkene represented by formula [2] wherein each of R 1 , R 2 , R 3 , R 4 and R 5 independently represents the same substituent as above, in the presence of a transition metal complex having an optically active ligand and in the absence of a reaction solvent that is different from the fluorine-containing α-ketoester and the alkene.