Patent ID: 8993722
Filing Date: 2015-03-31
Classification: A61P,C07K,C08G

Abstract:
1. A process for preparing copolymer-1, comprising: reacting protected copolymer-1 with hydrobromic acid for 1 to 5 hr at 35-45° C. to form trifluoroacetyl copolymer-1; washing the trifluoroacetyl copolymer-1 with organic solvent, thus removing benzyl bromide, wherein the organic solvent comprises a hydrocarbon, a halogenated hydrocarbon, an alcohol, an ether, or an ester; treating the trifluoroacetyl copolymer-1 with aqueous piperidine to form copolymer-1; and purifying the copolymer-1; wherein copolymer-1 has a molecular weight of 5,000 to 9,000 Daltons and is glatiramer acetate comprising a mixture of polypeptides composed of glutamic acid, alanine, tyrosine, and lysine in a molar ratio of approximately of 0.141, 0.427, 0.095 and 0.338.