Patent ID: 6465508
Filing Date: 2002-10-15
Classification: C07D

Abstract:
A compound of formula I where the hydroxamic acid moiety and the sulfonamido moiety are bonded to adjacent carbons of group A wherein:A is aryl; Z is aryl; E and G are independently CH2, NR5, or O, or S or a bond: Y is cycloalkyl, â€”C1-C5-perfluoroalkyl, alkyl, alkenyl, alkynyl, or alkylaryl; J is benzothienyl or benzofuranyl; R5 and R6 are independently H, aryl, heteroaryl, cycloalkyl, cycloheteroalkyl, â€”C1-C4-perfluoroalkyl, alkyl, alkenyl, or alkynyl; R7 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or 3-6 membered cycloheteroalkyl; or R7CH2â€”Nâ€”Aâ€” can form a non-aromatic 1,2-benzo-fused 7-10 membered heterocyclic ring optionally containing an additional heteroatom selected from O, S and N wherein said heterocyclic ring may be optionally fused to another benzene ring; L is â€”C(O)â€”, S(O)y, â€”NR5C(O)NR6â€”, â€”NR5C(O)Oâ€”, â€”OC(O)NR5â€”, â€”SC(O)â€”, â€”C(O)Sâ€”, â€”NR5C(O)â€”, â€”C(O)NR5â€”, â€”SC(O)NR5, â€”NR5C(O)Sâ€”, â€”OC(O)Oâ€”; y is 1 or 2; or the pharmaceutically acceptable salts thereof or the optical isomers or diastereomers thereof.