Patent ID: 6174898
Filing Date: 2001-01-16
Classification: A61K,A61P,Y02A

Abstract:
A method of treating filariae in the lymphatic system in a subject in need thereof comprising administering to said subject an effective amount of a compound of formula I ##STR3##wherein A is ##STR4##wherein R.sup.1 and R.sup.2 independently are furanyl, imidazolyl, oxazolyl, phenyl, pyrazolyl, pyrazinyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, thiazolyl, thienyl or triazolyl wherein each aromatic ring is optionally substituted with one, two or three substituents selected from --NR.sup.8 R.sup.9, C.sub.1-6 -alkylthio, C.sub.1-6 -alkoxy, azido, cyano, halogen, hydroxy, C.sub.1-6 -alkyl, nitro, mercapto or trifluoromethyl; andX is --CH.sub.2 --, --O-- or --N(R.sup.3)-- wherein R.sup.3 is hydrogen or C.sub.1-6 -alkyl; andR.sup.4 is hydrogen or C.sub.1-6 -alkyl; andm is 1 or 2; andn is 1 when m is 1 and n is 0 when m is 2; andR.sup.5 and R.sup.6 each represents hydrogen or may when m is 2 together represent a bond; andR.sup.7 is hydroxy or C.sub.1-6 -alkoxy; andR.sup.8 and R.sup.9 independently are hydrogen or C.sub.1-6 -alkyl; andp is 0, 1, 2 or 3; andq is 0, 1 or 2; andr is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.