Patent ID: 8564288
Filing Date: 2013-10-22
Classification: G01R

Abstract:
1. A method for preparation of a sample, containing a solute to be investigated, for magnetic resonance (=MR) measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, the method comprising the steps of: a) preparing frozen beads of a first kind containing paramagnetic stable radicals, in addition to the solute under investigation and suitable solvents; b) preparing frozen beads of a second kind containing a reducing agent dissolved in a solvent; c) inserting the frozen beads of the first kind into a polarizing magnet; d) inserting the frozen beads of the second kind into the polarizing magnet together with the frozen beads of the first kind; e) creating enhanced polarization of nuclei within the frozen beads of the first kind in the polarizing magnet at cryogenic temperatures; f) heating the frozen beads of the first and second kinds, thereby obtaining a polarized mixed solution at room temperature; g) transferring the polarised mixed solution from the polarizing magnet to an MR magnet; h) reducing the paramagnetic stable radicals with the reducing agent during step g); and i) carrying out an MR measurement on the mixed solution prepared in steps a) to h), wherein steps b), d) and f) are used to quench relaxation due to paramagnetic stable radicals.