Patent ID: 6762330
Filing Date: 2004-07-13
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
A process to prepare biaryls of the formula R1-R7 comprising contacting a Grignard reagent of the formula R7â€”MgX with an aryl compound of the formula R1â€”X in the presence of a catalytic amount of a coordination compound comprising one or more transition metals complexed to a phosphine oxide compound of the formula HP(O)R4R5 or a phosphine sulfoxide compound of the formula HP(S)R4R5,wherein X is a halogen;R1 is an optionally substituted aryl; R7 is selected from the group consisting of hydrocarbyl, substituted hydrocarbyl, hydrocarbylamino, alkoxy, aryloxy, and heterocyclic; and R4 and R5 are independently selected from the group consisting of hydrocarbyl, substituted hydrocarbyl, heterocyclic, organometallic, Cl, Br, I, SQ1, OQ2, PQ3Q4, and NQ5Q6, where Q1, Q2, Q3, Q4, Q5, and Q6 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, hydrocarbylamino, alkoxy, aryloxy, and heterocyclic, and optionally R4 and R5 can together form a ring.