Patent ID: 7235400
Filing Date: 2007-06-26
Classification: B01F,B01J,B01L,C40B,G01N

Abstract:
1. A microfluidic interface device for adhering to a substrate to form a sealed reaction chamber, comprising: a flexible main structure comprising a plurality of substantially planar flexible layers laminated together, wherein the layers comprise: a support layer; a diaphragm layer laminated directly or indirectly to the support layer; and at least two mixing bladders disposed between the support layer and the diaphragm layer; and an adhesive gasket laminated directly or indirectly to the diaphragm layer of said main structure, wherein said gasket defines the wall of a reaction chamber and is adapted to reversibly seal against a substrate to form a closed reaction chamber, said reaction chamber bounded by said substrate, the diaphragm layer, and said gasket; wherein said flexible main structure is sufficiently flexible that the gasket is capable of being released from the substrate without breaking the substrate during disassembly; and wherein each mixing bladder has at least one port providing communication between said mixing bladder and the exterior of said main structure and is adapted to connect to an external source of pressure or vacuum to produce alternate inflation or deflation of said mixing bladders and out of phase deflection of the diaphragm overlaying each opening of the mixing bladder layer, to thereby cause mixing of the fluid in the chamber.