Patent ID: 6096338
Filing Date: 2000-08-01
Classification: A61K,Y10S

Abstract:
A carrier system for a hydrophobic drug which comprises:(a) a digestible oil;(b) a pharmaceutically acceptable surfactant for dispersing the oil in vivo upon administration of the carrier system, said surfactant comprising a hydrophilic surfactant component, and being such that it does not substantially inhibit the lipolysis of the digestible oil, said surfactant comprising:(i) a hydrophilic surfactant component which substantially inhibits the in vivo livolysis of said digestible oil, and(ii) a lipophilic surfactant component capable of at least substantially reducing said inhibitory effect of said hydrophilic surfactant component, said lipophilic surfactant component being present in an amount sufficient to achieve the required counteracting of the lipolysis-inhibiting properties of said hydrophilic surfactant,said lipophilic surfactant component comprising one or more of oleic acid, a glyceryl mono-/di-caprylate surfactant and a glyceryl mono-/di-caprylate/caprate surfactant.