Patent ID: 6316436
Filing Date: 2001-11-13
Classification: C07D

Abstract:
A compound as illustrated by formula F: ##STR37##wherein:R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d are independently selected from:a) hydrogen,b) unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, R.sup.8 O--, R.sup.9 S(O).sub.q --, CN, NO.sub.2, R.sup.8 C(O)--, R.sup.8 OC(O)--, N(R.sup.8).sub.2, (R.sup.8).sub.2 NC(O)--, C(O)N(R.sup.8).sub.2 --, or N.sub.3 ;c) C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted by unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, R.sup.8 O--, R.sup.9 S(O).sub.q --, CN, R.sup.8 C(O)--, R.sup.8 OC(O)--, N(R.sup.8).sub.2, N.sub.3, or R.sup.8 C(O)O--;R.sup.1 is selected from:a) H,b) unsubstituted or substituted C.sub.1 -C.sub.6 alkyl,c) unsubstituted or substituted aryl,d) unsubstituted or substituted heterocycle,e) --(C.sub.1 -C.sub.6 alkyl)N(R.sup.8).sub.2,f) --R.sup.8 C(O)R.sup.8,g) --(C.sub.1 -C.sub.6 alkyl)OR.sup.8,h) --N(R.sup.8).sub.2,i) --OR.sup.8,j) --R.sup.8 NHC(O)R.sup.8,k) --R.sup.8 C(O)N(R.sup.8).sub.2,l) CF.sub.3,m) halo,n) --C(O)OR.sup.8,o) C.sub.2 -C.sub.6 alkynyl,p) C.sub.2 -C.sub.6 alkenyl,q) perfluoroalkyl,r) N.sub.3,s) NO.sub.2,t) CN, andu) R.sup.9 S(O).sub.q --R.sup.2 is selected from:a) hydrogen,b) CN,c) NO.sub.2,d) halogen,e) aryl, unsubstituted or substituted,f) heteroaryl, unsubstituted or substituted,g) C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted,h) OR.sup.8,i) N.sub.3,j) R.sup.9 S(O).sub.q,k) R.sup.8 HC.dbd.CH--, andl) R.sup.8 C.ident.C--;R.sup.3 is selected from:a) H,b) CN,c) NO.sub.2,d) halogen,e) C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted,f) OR.sup.8,g) aryl, unsubstituted or substituted,h) heteroaryl, unsubstituted or substituted, andi) CF.sub.3 ;R.sup.4 is H;R.sup.5 is selected from:a) H,b) CN,c) NO.sub.2,d) halogen,e) C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted,f) N.sub.3,g) R.sup.9 S(O).sub.q,h) --HC.dbd.CH.sub.2,i) HC.ident.C--,j) aryl, unsubstituted or substituted,k) heterocycle, unsubstituted or substituted,l) CF.sub.3 O--,m) CF.sub.3 CH.sub.2 O--,n) C.sub.3 -C.sub.10 cycloalkyl,o) CF.sub.3,p) --(C.sub.1 -C.sub.6 alkyl)N(R.sup.8).sub.2,q) --(C.sub.1 -C.sub.6 alkyl)OR.sup.8,r) OR.sup.8,s) N(R.sup.8).sub.2,t) --C(O)(C.sub.1 -C.sub.6 alkyl), andu) --(C.sub.1 -C.sub.6 alkyl)C(O)R.sup.8 ;R.sup.8 is independently selected from hydrogen, unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted benzyl, unsubstituted or substituted heterocycle and unsubstituted or substituted aryl;R.sup.9 is independently selected from unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted benzyl and unsubstituted or substituted aryl;A.sup.1 is selected from:a) a bond, orb) O;X is selected from: a bond or --C(.dbd.O)--;Z is an aryl;m is 0, 1, 2, 3 or 4;n is 0, 1, 2, 3 or 4;p is 0, 1, 2, 3 or 4;q is 0, 1 or 2;r is 0, 1, 2, 3, or 4;s is 0, 1, 2, 3 or 4;u is 0, 1, 2, 3 or 4;or a pharmaceutically acceptable salt or stereoisomer thereof.