Patent ID: 6458844
Filing Date: 2002-10-01
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: where in X is a group of the formula R15 is halogen, nitro, lower alkyl sulfonyl, cyano, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, lower alkyl aminosulfonyl, perfluorolower alkyl, lower alkylthio, hydroxy lower alkyl, alkoxy lower alkyl, lower alkylthio lower alkyl, lower alkylsulfinyl lower alkyl, lower alkylsulfonyl lower alkyl, lower alkylsulfinyl, lower alkanoyl, aroyl, aryl, aryloxy; R16 is hydrogen, halogen, nitro, cyano, lower alkyl, OH, perfluorolower alkyl, or lower alkylthio; Y is a ring of the formula R25, is lower alkyl, unsubstituted or fluorine substituted lower alkenyl, or a group of formula R26â€”(CH2)eâ€”, R26 is aryl, heteroaryl, azido, cyano, hydroxy, lower alkoxy, lower alkoxycarbonyl, lower alkanoyl, lower alkylthio, lower alkyl sulfonyl, lower alkyl sulfinyl, perfluoro lower alkanoyl, nitro, or â€”NR28R29; R28 is H or lower alkyl, R29 is hydrogen, lower alkyl , lower alkoxycarbonyl, lower alkanoyl, aroyl, perfluoro lower alkanoyamino, lower alkyl sulfonyl, lower alkylaminocarbonyl, arylaminocarbonyl, or R28 and R29 taken together form a 4, 5 or 6-membered saturated carbocyclic ring optionally containing one heteroatom selected from O, S, and N; with the carbon atoms in the ring being unsubstituted or substituted by lower alkyl or halogen; Q is â€”(CH2)fOâ€”, â€”(CH2)fSâ€”, â€”(CH2)fN(R27)â€”, or â€”(CH2)fâ€”; R27 is H, lower alkyl, aryl, lower alkanoyl, aroyl or lower alkoxycarbonyl; e is an integer from 0 to 4, and f is an integer from 0 to 3; and the dotted bond is optionally hydrogenated; or pharmaceutically acceptable salts or esters thereof.