Patent ID: 8551720
Filing Date: 2013-10-08
Classification: A61K,C12Q,G01N

Abstract:
1. A method for detecting, and/or monitoring, a non-cancerous colorectal disease in a subject, comprising: (a) providing a sample from a subject; (b) measuring an amount of a BD-marker protein in the subject sample using an immunoassay; (c) measuring an amount of BD-marker protein in a control sample using the immunoassay; (d) comparing the amount from (b) to the amount from (c) to detect a difference between the amount of the BD-marker protein in the control sample and the amount of the BD-marker protein in the subject sample; and (e) diagnosing the subject as having a non-cancerous colorectal disease when the difference detected in step (d) shows a loss of the BD-marker protein or a reduction in the amount of the BD-marker protein in the subject sample relative to the amount of the BD-marker protein in the control sample, wherein the BD-marker protein is AKR1B10, and further wherein the non-cancerous colorectal disease is selected from the group consisting of non-cancerous rectal disease, non-cancerous chronic colorectal disease, non-cancerous chronic inflammatory bowel disease, adenoma, inflammatory bowel disease, ulcerative colitis, and Crohn's disease.