Patent ID: 6812232
Filing Date: 2004-11-02
Classification: A61P,C07D

Abstract:
A compound of the following formula: wherein:R1 are the same or different and independently selected from the group consisting of: H; C1-C6-straight chain alkyl; C2-C6-straight alkenyl chain; C3-C6-branched alkyl chain; C3-C6-branched alkenyl chain; C3-C7-cycloalkyl; CH2â€”(C3-C7-cycloalkyl); CH2CF3; CH2CH2CF3; and CH(CF3)2; V=NH; O; S; or CH2; R2=phenyl; substituted phenyl, wherein the substituents (1-2 in number) are in any position and are independently selected from the group consisting of R1, OR1, SR1, S(O)R1, S(O2)R1, NHR1, NO2, OC(O)CH3, NHC(O)CH3, F, Cl, Br, CF3, C(O)R1, C(O)NHR1, phenyl, and C(O)NHCHR1CH2OH; 1-naphthyl; 2-naphthyl; heterocycles selected from the group consisting of: 2-pyridyl; 3-pyridyl; 4-pyridyl; 2-pyrimidyl; 4-pyrimidyl; 5-pyrimidyl; thiophene-2-yl; thiophene-3-yl; 2-furanyl; 3-furanyl; oxazol-2-yl; oxazol-4-yl; oxazol-5-yl; thiazol-2-yl; thiazol-4-yl; thiazol-5-yl; imidazol-2-yl; imidazol-4-yl; pyrazol-3-yl; pyrazol-4-yl; isoxazol-3-yl; isoxazol-4-yl; isoxazol-5-yl; isothiazol-3-yl; isothiazol-4-yl; isothiazol-5-yl; 1,3,4-thiadiazol-2-yl; benzo[b]furan-2-yl; benzo[b]thiophene-2-yl; 2-pyrrolyl; 3-pyrrolyl; 1,3,5-triazin-2-yl; pyrazin-2-yl; pyridazin-3-yl; pyridazin-4-yl; 2-quinolinyl; 3-quinolinyl; 4-quinolinyl; 1-isoquinolinyl; 3-isoquinolinyl; and 4-isoquinolinyl; or substituted heterocycle, wherein the heterocycle is as defined above and the substituents (1-2 in number) are in any position and are independently selected from the group consisting of Br, Cl, F, R1, and C(O)CH3; R3 are the same or different and independently selected from the group consisting of: H; C1-C4-straight chain alkyl; C3-C4-branched chain alkyl; C2-C4-alkenyl chain; (CH2)nPh; and (CH2)n-substituted phenyl, wherein the phenyl substituents are as defined above in R2; R4=H; C1-C4-straight chain alkyl; or C3-C4-branched chain alkyl; R3 and R4 can be linked together by a carbon chain to form with intervening atoms a 5-8-membered saturated or unsaturated ring; n1=0-3; n=0-3; A=CH2; (CH2)2; (CH2)3; OCH2CH2; or CHCH3; Y=H; OR1; N(R1)2; N(R1)C(O)R3; N(R1)C(O)R5; N(R1)C(O)CH(R6)NH2; N(R1)SO2R3; N(R1)C(O)NHR3; or N(R1)C(O)OR6; R5=C3-C7-cycloalkyl; R6=C1-C4-straight chain alkyl; C3-C4-branched chain alkyl; C2-C4-alkenyl chain; (CH2)nPh; or (CH2)n-substituted phenyl, wherein the phenyl substituents are as defined above in R2; R7 is a heterocycle selected from the group consisting of: thiophene; furan; pyrrole; thiazole; pyrazole; imidazole; isoxazole; isothiazole; and 1,3,4-thiadiazole; or a pharmaceutically acceptable salt thereof.