Patent ID: 8748636
Filing Date: 2014-06-10
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a benzofuran derivative substituted at position 5 of formula I: in which R represents a nitro or ester group —COOR′, in which R′ represents a hydrogen atom or an alkyl group; R 1 represents hydrogen or an alkyl group; and R 2 represents hydrogen, a halogen, haloalkyl, alkyl, alkoxy, dialkylaminoalkoxy or dialkylaminoalkyl group; said process comprising coupling a hydroxylamine of formula II: in the presence of an acid, with a diketone of formula III: in which R 1 and R 2 have the same meaning as above, to form an oxime of formula IV: in the form of a mixture of E and Z isomers, in which R 1 and R 2 have the same meaning as above, and cyclizing this oxime by heating to form the desired compound.