Patent ID: 6432924
Filing Date: 2002-08-13
Classification: A61K,C07H,Y10S

Abstract:
A pharmaceutical or veterinary composition, comprising a phamaceutically or veterinarily acceptable carrier, and an active agent that, when administered to a subject, is effective for countering or diagnosing cytidine deaminase or deoxycytidine deaminase over-expression or a disorder associated with it, or an increase in number or toxicity of pro-inflammatory cells Thai over-express cytidine deaminase or deoxycytidine dearminase or a disorder associated with it, or HIV infection or a disorder associated with HIV infection, or cancer or arthritis; the agent having the chemical formula C7N3H8O2R1R2XX1, wherein X and X1 are each independently C or N, but not simultaneously both C in the case of HIV infection or a disorder associated with HIV infection; R1 is selected from lower alkyl, alkenyl and alkynyl, halogen or haloalkyl; and R2 is selected from H, â€”N3, â€”OH, amino or halogen, or pharmaceutically acceptable salts thereof.