Patent ID: 6096754
Filing Date: 2000-08-01
Classification: A61K,C07D

Abstract:
Compounds of general formula I ##STR9## wherein: R represents a straight, branched or cyclic lower alkyl of 1 to 5 carbon atoms, optionally substituted by a OR.sub.4 group, where R.sub.4 represents hydrogen or a C.sub.1 -C.sub.4 alkyl; or a lower alkenyl group of up to 5 carbon atoms,R.sub.1 and R.sub.3 represent independently hydrogen or a C.sub.1 -C.sub.4 alkyl,R.sub.2 represents a CN group; a CH.sub.2 OR.sub.5 group wherein R.sub.5 represents hydrogen or a C.sub.1 -C.sub.4 alkyl; a COR.sub.6 group wherein R.sub.6 represents a C.sub.1 -C.sub.4 alkyl or a NR.sub.7 R.sub.5 group wherein R.sub.7 and R.sub.8, which are the same or different, represent hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl,n represents 1 or 2,A, A.sub.1, A.sub.2, represent independently N, O, S atoms, or (CH).sub.m, wherein m=1, 2, with the proviso that at least one be a heteroatom, and they form, together with two carbon atoms, a 5- or 6-membered heterocyclic ring,Z represents a COOR.sub.9 group, wherein R.sub.9 represents hydrogen or a C.sub.1 -C.sub.4 alkyl; a NHSO.sub.2 CF.sub.3 group; a CN group; a NO.sub.2 group; a SO.sub.2 NHR.sub.10 group, wherein R.sub.10 represents hydrogen, COR.sub.11, wherein R.sub.11 represents an optionally substituted phenyl, a C.sub.1 -C.sub.4 alkyl, a C.sub.1 -C.sub.4 alkoxy, or CONHR.sub.12, where R.sub.12 is a straight or branched C.sub.1 -C.sub.4 alkyl; a tetrazol-5-yl group;and the pharmaceutically acceptable salts thereof.