Patent ID: 6608053
Filing Date: 2003-08-19
Classification: A61K,C07D

Abstract:
A fused heteroaryl compound of formula (Ia): or a salt thereof, wherein: R2 and R3, which may be the same or different, are independently â€”H or -a lower alkyl, or R2 and R3 are combined together with the N atom adjacent thereto to form a nitrogen-containing saturated heterocyclic group as â€”NR2R3 which may have 1 or 2 substituents selected from the group comprising of â€”OH, &boxH;O and -a lower alkyl; X is N; Y is O, S or NH; R41 is -(an aryl which may have one to 5 substituents selected from Group A4), -a lower alkylene-(an aryl which may have one to 5 substituents selected from Group A4), -a lower alkenylene-(an aryl which may have one to 5 substituents selected from Group A4), -a lower alkynylene-(an aryl which may have one to 5 substituents selected from Group A4), -(a cycloalkyl which may have one to 5 substituents selected from Group A), -(a cycloalkenyl which may have one to 5 substituents selected from Group A), -a lower alkylene-(a cycloalkyl which may have one to 5 substituents selected from Group A), -a lower alkenylene-(a cycloalkyl which may have one to 5 substituents selected from Group A), -a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may have one to 5 substituents selected from Group A), -a lower alkenylene-(a nitrogen-containing saturated heterocyclic group which may have one to 5 substituents selected from Group A), -(a heteroaryl which may have one to 5 substituents selected from Group A4), -a lower alkylene-(a heteroaryl which may have one to 5 substituents selected from Group A4), or -a lower alkenylene-(a heteroaryl which may have one to 5 substituents selected from Group A4); and Group A consists of -a lower alkyl, -a lower alkenyl, -a lower alkynyl, -a halogen, -a halogenated lower alkyl, -a lower alkylene-OR, â€”NO2, â€”CN, &boxH;O, â€”OR, â€”O-a halogenated lower alkyl, â€”O-a lower alkylene-NRRâ€², â€”O-a lower alkylene-OR, â€”O-a lower alkylene-an aryl, â€”SR, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOR, â€”COO-a lower alkylene-an aryl, â€”COR, â€”CO-an aryl, -an aryl, â€”CONRRâ€², â€”SO2NRRâ€², â€”NRRâ€², â€”NRâ€³-a lower alkylene-NRRâ€², â€”NRâ€²-a lower alkylene-OR, â€”NR-a lower alkylene-an aryl, â€”NRCO-a lower alkyl, â€”NRSO2-a lower alkyl, -a cycloalkyl and -a cycloalkenyl; and wherein R, Râ€²and Râ€³, which may be the same or different, represent H or a lower alkyl; Group A4 consists of a) -a lower alkyl, -a lower alkenyl, -a lower alkynyl, -a halogen, -a halogenated lower alkyl, -a lower alkylene-OR, â€”NO2, â€”CN, &boxH;O, â€”O-halogenated lower alkyl, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOR, â€”COO-a lower alkylene-an aryl, â€”COR, â€”CO-an aryl, â€”CONRRâ€², â€”SO2NRRâ€², -Cyc or -Alp-Cyc (wherein Alp is a lower alkylene, a lower alkenylene or a lower alkynylene, and Cyc is an aryl which may have 1 to 5 substituents selected from Group A, a heteroaryl which may have 1 to 5 substituents selected from Group A, a nitrogen-containing saturated heterocyclic group which may have 1 to 5 substituents selected from Group A, a cycloalkyl which may have 1 to 5 substituents selected from Group A, or a cycloalkenyl which may have 1 to 5 substituents selected from Group A; b) â€”NR-E-F (wherein B is â€”COâ€”, â€”COOâ€”, â€”CONRâ€²â€”, â€”SO2NRâ€²â€” or â€”SO2â€”; F is -Cyc or -(a lower alkyl, a lower alkenyl or a lower alkynyl which may be substituted by one or more substituents selected from the group comprising of -a halogen, â€”NO2, â€”CN, â€”OR, â€”O- a lower alkylene-NRRâ€², â€”O-a lower alkylene-OR, â€”SR, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOR, â€”COR, â€”CO-an aryl, â€”CONRRâ€², â€”SO2NRRâ€², â€”NRCO-a lower alkyl, â€”NRRâ€², â€”NRâ€²-a lower alkylene-OR, â€”NRâ€³-a lower alkylene-NRRâ€² and -Cyc), and c) â€”Zâ€”Râ€², â€”Z-Cyc, â€”Z-Alp-Cyc, â€”Z-Alp-Zâ€²â€”Râ€² or â€”Z-Alpâ€”Zâ€²-Cyc (wherein each of Z and Zâ€², which may be the same or different, are independently O, S or NR.