Patent ID: 7129357
Filing Date: 2006-10-31
Classification: A61P,C04B,C07C,C07D

Abstract:
1. A process of making a compound of formula IV comprising: (1) reacting a compound of formula V with a compound of formula VI to yield a compound of formula VII:  wherein A is selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, —CF M is selected from the group consisting of Br, Cl, I, —CN, —C(O)OR, —C(O)NR Z is selected from the group consisting of halogen, —OR R is selected from the group consisting of H, alkyl, aryl, aralkyl, heteroaryl, cycloalkyl, and heterocyclyl; and R (2) cyclizing the compound of formula VII to yield a compound of formula VIII: (3) converting the compound of formula VIII to yield a compound of formula IX:  and (4) reacting the compound of formula IX with a compound of formula X to yield the compound of formula IV: