Patent ID: 8486951
Filing Date: 2013-07-16
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula Ia and pharmaceutically acceptable salts, hydrates, solvates, and tautomers thereof; wherein Q1 and Q2 are each individually and independently selected from the group consisting of N and CH and wherein at least one of Q1 and Q2 are N; each D is individually taken from the group consisting of C, CH, C—R20, N—Z3, N, and O, such that the resultant ring is taken from the group consisting of pyrazolyl, isoxazolyl, triazolyl and imidazolyl; V is NR4, or each Q5 is C(Z2B) W is —[C(R13)R14] A is selected from the group consisting of phenyl, pyridinyl, thienyl, indanyl, tetrahydronapthyl, naphthyl, pyrazinyl, pyridazinyl, triazinyl, and pyrimidinyl; when A has one or more substitutable sp2-hybridized carbon atoms, each respective sp2 hybridized carbon atom may be optionally substituted with a Z1B substituent; when A has one or more substitutable sp3-hybridized carbon atoms, each respective sp3 hybridized carbon atom may be optionally substituted with a Z2B substituent; each Z1B is independently and individually selected from the group consisting of hydrogen, halogen, C1-6alkyl, branched C3-C7alkyl, fluoroC1-C6alkyl wherein the alkyl moiety can be partially or fully fluorinated, C1-C6alkoxy, fluoroC1-C6alkoxy wherein the alkyl moiety can be partially or fully fluorinated, and —(CH each Z2B is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, and branched C3-C7alkyl; each Z3 is independently and individually selected from the group consisting of C1-C6alkyl, hydrogen, branched C3-C7alkyl, C3-C8cycloalkyl, fluoroC1-C6alkyl wherein the alkyl moiety can be partially or fully fluorinated, hydroxyC2-C6alkyl-, R5C(O)(CH each R2 is selected from the group consisting of hydrogen, R17-substituted aryl-, C1-C6alkyl, branched C3-C8alkyl, R19 substituted C3-C8cycloalkyl-, and fluoroC1-C6alkyl- wherein the alkyl is fully or partially fluorinated; wherein each R3 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, branched C3-C7alkyl, and C3-C8cycloalkyl; each R4 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, hydroxyC1-C6alkyl-, dihydroxyC1-C6alkyl-, C1-C6alkoxyC1-C6alkyl-, branched C3-C7alkyl, hydroxyl substituted branched C3-C6alkyl-, C1-C6alkoxy branched C3-C6alkyl-, dihydroxy substituted branched C3-C6alkyl-, —(CH each R5 is independently and individually selected from the group consisting of and wherein the symbol (##) is the point of attachment to respective R4, R7, R8, R20 or Z3 moieties containing a R5 moiety; each R7 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, hydroxyC2-C6alkyl-, dihydroxyC2-C6alkyl-, C1-C6alkoxyC2-C6alkyl-, branched C3-C7alkyl, hydroxy substituted branched C3-C6alkyl-, C1-C6alkoxy branched C3-C6alkyl-, dihydroxy substituted branched C3-C6alkyl-, —(CH each R8 is independently and individually selected from the group consisting of C1-C6alkyl, branched C3-C7alkyl, fluoroC1-C6alkyl- wherein the alkyl moiety is partially or fully fluorinated, R19 substituted C3-C8cycloalkyl-, phenyl, phenylC1-C6alkyl-, OH, C1-C6alkoxy, —N(R3) each R10 is independently and individually selected from the group consisting of —CO R13 and R14 are each individually and independently selected from the group consisting of hydrogen, C1-C6alkyl, branched C3-C8alkyl, fluoroC1-C6alkyl- wherein the alkyl is fully or partially fluorinated, hydroxyl substituted C1-C6alkyl-, C1-C6alkoxy substituted C1-C6alkyl-, hydroxyl substituted branched C3-C8alkyl-, and alkoxy substituted branched C3-C8alkyl; each R16 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, branched C3-C7alkyl, R19 substituted C3-C8cycloalkyl-, halogen, fluoroC1-C6alkyl- wherein the alkyl moiety can be partially or fully fluorinated, cyano, hydroxyl, C1-C6alkoxy, fluoroC1-C6alkoxy- wherein the alkyl moiety can be partially or fully fluorinated, —N(R3) each R17 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, branched C3-C7alkyl, hydroxyC2-C6alkyl-, R19 substituted C3-C8cycloalkyl-, halogen, fluoroC1-C6alkyl- wherein the alkyl moiety can be partially or fully fluorinated, cyano, hydroxyl, C1-C6alkoxy, fluoroC1-C6alkoxy- wherein the alkyl moiety can be partially or fully fluorinated, —N(R3) each R19 is independently and individually selected from the group consisting of hydrogen, OH and C1-C6alkyl; each R20 is independently and individually selected from the group consisting of hydrogen, C1-C6alkyl, branched C3-C7alkyl, R19 substituted C3-C8cycloalkyl-, halogen, fluoroC1-C6alkyl- wherein the alkyl moiety can be partially or fully fluorinated, cyano, hydroxyl, hydroxyC1-C6alkyl-, C1-C6alkoxyC1-C6alkyl-, C1-C6alkoxy, fluoroC1-C6alkoxy- wherein the alkyl moiety can be partially or fully fluorinated, —N(R3) each m is independently and individually 1-3, each n is independently and individually 0-6; each p is independently and individually 1-4; each q is independently and individually 2-6; each v is independently and individually 1 or 2; each x is independently and individually 0-2; stereoisomers, regioisomers and tautomers of such compounds.