Patent ID: 6531133
Filing Date: 2003-03-11
Classification: A61K,C07K,Y10S

Abstract:
A chimeric protein, consisting of a Pseudomonas aeruginosa exotoxin (PE) moiety as a cytotoxic agent linked to a myelin basic protein (MBP) moiety selected from the group consisting of:(a) amino acids 69-88 of guinea-pig myelin basic protein, encoded by nucleotides 8-64 of SEQ ID NO:1, or an antigenic portion thereof recognizing anti-MBP specific T-cells; (b) amino acids 84-102 (SEQ ID NO:15) of human myelin basic protein or an antigenic portion thereof recognizing anti-MBP specific T-cells; and (c) amino acids 143-168 (SEQ ID NO:16) of human myelin basic protein or an antigenic portion thereof recognizing anti-MBP specific T-cells, wherein one of said MBP amino acid sequences (a), (b) and (c) is linked to said PE moiety by a pentapeptide or by a peptide consisting of said pentapeptide repeated twice.