Patent ID: 7291602
Filing Date: 2007-11-06
Classification: C07H

Abstract:
1. A compound represented by formula (I): or the pharmaceutically acceptable salts, and esters thereof, wherein W is selected from the group consisting of: a) hydrogen; b) CN;  provided that when A=S(O) or SO R 1 is selected from the group consisting of: a) hydrogen; b) deuterium; c) —CH d) aryl; e) substituted aryl; f) heteroaryl; g) substituted heteroaryl; and h) —C R 2 is: a) hydrogen; b) hydroxy; or c) activated hydroxy; when R 1 is H, R 2 is selected from the group consisting of: a) hydrogen; b) hydroxy; c) activated hydroxy; d) N e) NH f) CN; g) protected hydroxy; h) protected amino; i) -A-R  provided that when A=S(O) or SO wherein G is absent, O, S, S(O), S(O) 2 , NR 4 , N(CO)R 4 , NSO 2 R 4 , or CHR 4 ; n=1, 2, or 3; and m=2 or 3, where R 3 is as previously defined; or alternatively, R 1 and R 2 taken together with the carbon atom to which they are attached is selected from the group consisting of: a) C═O; b) C(OR c) C(SR d) C═CHR e) C═CNH; and f) C═N-Z-R X and Y are: (a) when one of X and Y is a hydrogen, the other is selected from the group consisting of: wherein G is absent, O, S, S(O), S(O) 2 , NR 4 , N(CO)R 4 , NSO 2 R 4 , or CHR 4 ; n=1, 2, or 3; and m=2 or 3, where R 4 is as previously defined; or b) X and Y taken together with the carbon atom to which they are attached is: B is NR 30 R 40 ; wherein R 30 and R 40 is independently selected from the group consisting of hydrogen, acyl, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, saturated or unsaturated heterocyclic group; or can be taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted heterocyclic or heteroaromatic ring; V is selected from the group consisting of hydrogen, azido, cyano, nitro, aldehyde, carboxylic acid, amide, a substituted or unsubstituted, saturated or unsaturated aliphatic; Q is selected from the group consisting of: (a) hydrogen; (b) protected hydroxy; and (c) OR L is selected from the group consisting of: (a) —CH (b) —CH(OH)CH (c) —C R x is hydrogen, hydroxyl protecting group or hydroxyl prodrug group.