Patent ID: 8795251
Filing Date: 2014-08-05
Classification: A61B,A61K,A61N,Y10S

Abstract:
1. A method of drug delivery and thermal damage to target tumor cells in a patient in need thereof, the method comprising administering anti-tumor antibody specific coated drug containing nanoparticles to a patient in need thereof, the nanoparticles forming an antibody labeled nanoparticle-cell complex at a target site, thereafter locally administering thermal therapy at the tumor site containing the anti-tumor antibody specific coated drug containing nanoparticles wherein the nanoparticles respond by expanding thus generating a an acoustic signal, measuring the acoustic signal and relating the measured signal to controlling the temperature of the nanoparticle tumor cell complex from at least 37° C. to 43° C. for the first temperature for an initial stage of thermotherapy, and at least one of 43° C. to 58° C., 43° C. to 45° C., 43° C. to 58° C., 45° C. to 50° C., 50° C. to 58° C., 58° C. to 60° C., greater than 58° C., or greater than 60° C. for the second temperature, based on the acoustic signal, the thermotherapy resulting in specific drug delivery and thermal damage to tumor cells.