Patent ID: 8372432
Filing Date: 2013-02-12
Classification: A61K,A61P

Abstract:
1. A dosage form for extended release of an opioid and acetaminophen, comprising: an extended release (ER) portion comprising a polymer matrix with a first dose of acetaminophen and a first dose of an opioid selected from oxycodone and hydrocodone dispersed therein, said polymer matrix comprised of between about 20-60 weight percent poly(ethylene oxide) having a molecular weight of between about 900,000 Daltons to 4,000,000 Daltons, wherein said matrix swells upon imbibition of fluid to a size sufficient to promote gastric retention in a gastrointestinal tract of a subject, said first dose of acetaminophen released from the dosage form through erosion of the polymer matrix, and said first doses of opioid and acetaminophen controllably-released from the dosage form such that substantially all of each of the first doses is released within about ten hours, when measured in an in vitro disintegration test using a USP type II apparatus at 37° C. in 0.1N HCI.