Patent ID: 7919260
Filing Date: 2011-04-05
Classification: A61P,G01N

Abstract:
1. A method of screening a compound or a salt thereof that changes the binding property of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 or the amino acid sequence having at least about 90% homology to the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, to a ligand capable of specifically binding to said protein or a salt thereof, which comprises assaying the binding amounts of said ligand to said protein, or a salt thereof, (a) in the case of contacting said ligand with said protein, or a salt thereof and (b) in the case of contacting said ligand and a test compound with said protein, or a salt thereof, and comparing the binding amounts, wherein a change in binding amounts of said ligand with said protein compared to the binding amounts of said ligand and test compound with said protein indicates that the compound changes the binding property of a protein, the ligand being a reserpine compound, methoctramine compound, or N-[3-(3-chlorophenoxy)phenyl]-2-methyl-8-[3-(1-piperazinyl)propyl]-5, 6, 7, 8-tetrahydropyrido[2, 3-d]pyrimidine-5-amine tetrahydrochloride.