Patent ID: 7074768
Filing Date: 2006-07-11
Classification: A61K,C07H,C12N

Abstract:
1. A method for inhibiting proliferation of cancer cells comprising: (a) administering to the cells a first therapeutic agent comprising a synthetic, modified antisense oligonucleotide fully complementary to at least 15 consecutive nucleotides of nucleic acid sequence GCCAGTGAGGAGGCACGC (SEQ ID NO:11) encoding N-terminal codons 8–13 of protein kinase A subunit RIα, and wherein the oligonucleotide is a hybrid, inverted hybrid, or inverted chimeric oligonucleotide, the hybrid oligonucleotide comprising a region of at least two deoxyribonucleotides, flanked by 3′ and 5′ flanking ribonucleotide regions each having at least four ribonucleotides, the inverted hybrid oligonucleotide comprising a region of at least four ribonucleotides flanked by 3′ and 5′ flanking deoxyribonucleotide regions of at least two deoxyribonucleotides, and the inverted chimeric oligonucleotide comprising an oligonucleotide nonionic region of at least four nucleotides flanked by two oligonucleotide phosphorothioate regions; and (b) administering to the cells a second therapeutic agent comprising an active ingredient for cancer therapy, wherein the administering steps may be performed simultaneously or sequentially in any order.