Patent ID: 8097456
Filing Date: 2012-01-17
Classification: A61L,B33Y,C12N

Abstract:
1. A tissue engineered structure comprising: a substrate defining micromachined surface structures, wherein said micromachined surface structures include nanotopographic features, the nanotopographic features having a first portion configured to enhance adhesion of a first cell type and a second portion configured to enhance adhesion of a second cell type and being arranged in such a manner so as to localize and organize the first and second cell types into desired subassemblies within said micromachined surface structures; a first cell type seeded microfluidically, and organized and localized on the substrate by the first portion to form a first subassembly; and a second cell type seeded microfluidically, and organized and localized on the substrate by the second portion to form a second subassembly.