Patent ID: 8057793
Filing Date: 2011-11-15
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating an autoimmune disease in a subject, wherein said autoimmune disease is mediated by B-cells, comprising administering to said subject a therapeutically effective amount of a chimeric or humanized monoclonal antibody that binds to CD20, said antibody having a light chain variable region CDR1 comprising the sequence of RASSSVSYIH (SEQ ID NO:1); CDR2 comprising the sequence of ATSNLAS (SEQ ID NO:4); and CDR3 comprising the sequence of QQWTSNPPT (SEQ ID NO:5); and said antibody having a heavy chain variable region CDR1 comprising the sequence of SYNMH (SEQ ID NO:8); CDR2 comprising the sequence of AIYPGNGDTSYNQKFKG (SEQ ID NO:9); and CDR3 comprising the sequence of STYYGGDWYFDV (SEQ ID NO:10) or the sequence of VVYYSNSYWYFDV (SEQ ID NO: 13).