Patent ID: 9040723
Filing Date: 2015-05-26
Classification: C07D,C08G

Abstract:
1. A method of synthesizing a substantially monodispersed mixture of oligomers comprising polyethylene glycol moieties of compounds represented by Formula IV, said method comprising steps of: (a) reacting a substantially monodispersed mixture of compounds having the structure of formula I wherein R wherein R (b) converting the compound of Formula II to a compound of Formula III in the presence of acid and water, wherein the acid is selected from the group consisting of p-Toluene sulphonic acid (PTSA), Pyridinium p-toluenesulfonate (PPTS), Trifluoro acetic acid (TFA), Methane sulphonic acid (MeSO wherein R (c) dissolving the compound of Formula III in at least one aprotic solvent, adding thionyl chloride at a temperature from about 0 to 40° C. to form an acid chloride and activating the acid chloride in the presence of N-hydroxysuccinimide and an aliphatic amine selected from the group consisting of monomethylamine, dimethylamine, trimethylamine, monoethylamine, diethylamine, triethylamine, monoisopropylamine, diisopropylamine, mono-n-butylamine, di-n-butylamine, tri-n-butylamine, monocyclohexylamine, dicyclohexylamine and mixtures thereof, to yield the compound of Formula IV