Patent ID: 6323223
Filing Date: 2001-11-27
Classification: A61P,C07D,Y02P

Abstract:
A compound of Formula (I): ##STR40##wherein:R.sup.1 and R.sup.2 are, independently of each other, hydrogen or alkyl;n is an integer from 0 to 2;m is an integer from 0 to 3;Ar and Ar.sup.1 are aryl;F is alkylene, alkenylene or a bond;each R is independently hydrogen or alkyl, or R together with either R.sup.3 or R.sup.4 and the atoms to which they are attached form a carbocycle or a heterocycle;R.sup.3 and R.sup.4 are, independently of each other, selected from:(i) hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclyalkyl, heteroalkyl, cyano, or -(alkylene)-C(O)--Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy, provided that both R.sup.3 and R.sup.4 are not hydrogen; or(ii) R.sup.3 and R.sup.4 together with the carbon atom to which they are attached form a carbocycle or a heterocycle;E is --SO.sub.2 N(R.sup.5)--, --N(R.sup.6)C(O)N(R.sup.5)--, --N(R.sup.6)SO.sub.2 N(R.sup.5)--, --N(R.sup.6)C(S)N(R.sup.5)--, --N(R.sup.6)C(O)O--, --OC(O)N(R.sup.6)--, or --N(R.sup.6)SO.sub.2 -- wherein:R.sup.5 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, heteroalkyl, or -(alkylene)-C(O)--Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy;R.sup.6 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, heteroalkyl, or -(alkylene)-C(O)--Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy;provided that when E is --SO.sub.2 N(R.sup.5)--, --N(R.sup.6)C(O)N(R.sup.5)--, --N(R.sup.6)SO.sub.2 N(R.sup.5)--, or --N(R.sup.6)C(S)N(R.sup.5)--, then m>0;Q is --R.sup.7 --W--R.sup.8 -- wherein:R.sup.7 is an alkylene chain of between 1-6 carbon atoms inclusive;R.sup.8 is a bond or an alkylene chain of between 0-4 carbon atoms inclusive;W is a bond or a group selected from --C(O)--, NR.sup.9 --, --O--, --S(O).sub.0-2 --, --N(R.sup.9)C(O)--, --N(R.sup.9)SO.sub.2 --, --SO.sub.2 N(R.sup.9)--, --N(R.sup.9)C(O)N(R.sup.9)--, --N(R.sup.9)SO.sub.2 N(R.sup.9)-- or --N(R.sup.9)C(S)N(R.sup.9)-- wherein:R.sup.9 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclyalkyl, heteroalkyl, or -(alkylene)-C(O)--Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy or heteroaralkyloxy;and individual isomers, mixture of isomers and pharmaceutically acceptable salts thereof.