Patent ID: 6054579
Filing Date: 2000-04-25
Classification: C07D

Abstract:
A method of preparing a compound represented by the following structural formula: ##STR8## comprising reacting a difunctional component, R.sup.2 --CO--(CR.sup.3 R.sup.4).sub.n --(CR.sup.5 R.sup.6)--CO.sub.2 H, an amine R.sup.1 --NH.sub.2, and an isocyanide, R--N.dbd.C, in the presence of a nucleophilic polar protic solvent,wherein n can be zero or an integer of one or more; andR, R.sup.1, and R.sup.2 are independently selected from the group consisting of: H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl and heterocyclic rings; andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently selected from the group consisting of: H, substituted or unsubstituted alkyl, alkoxy, hydroxy, aryl, aryloxy, aryloxycarbonyl, alkylamino, dialkylamino, amino, alkylthio, mercapto, halogen, nitro, cyano, carboxy, alkoxy carbonyl, acyloxy, aminocarbonyl, N-alkylamido, N,N-dialkylamido, acylamino, arylalkyl, sulfonic acid, sulfonic acid esters, isonitrilo, substituted or unsubstituted aryl and heterocyclic rings.