Patent ID: 6803460
Filing Date: 2004-10-12
Classification: C12P

Abstract:
A process for the recovery from a complex mixture of a compound of formula (I): whereinR0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulphur, or an oxidised form of sulphur; R1 is selected from the group consisting of hydrogen; hydroxy; halogen; saturated or unsaturated, straight or branched alkyl (1-5 carbon atoms), optionally substituted with hydroxy, halogen, aryl, or alkoxy (1-3 carbon atoms) or acyl; alkoxy (1-3 carbon atoms), optionally substituted with hydroxy or halogen; cycloalkyl (3-8 carbon atoms) optionally substituted with hydroxy, halogen, or amino; aryl; and heteroaryl; R2 is selected from the group consisting of adipyl, succinyl, glutaryl, pimelyl, suberyl, 2-(carboxyethylthio)acetyl, 3-(carboxyethylthio)propionyl, higher alkyl saturated and higher alkyl unsaturated dicarboxylic acids, wherein said complex mixture comprises in addition to the compound of formula (I), 6-aminopenicillanic acid (6-APA) and optionally one or more additional N-substituted &bgr;-lactam compounds, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 50Â° C. and 130Â° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) subjecting the mixture obtained after steps (a) and/or (b) to adsorption chromatography to obtain the compound of formula (I).