Patent ID: 8338472
Filing Date: 2012-12-25
Classification: A61P,C07D

Abstract:
1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R wherein the alkyl of choice (h) is optionally substituted with aryl, C 1-4 alkyl, and wherein the heteroaryl, aryl, heterocycle and cycloalkyl of choices (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), and (p) are optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of (1) hydroxyl, (2) halo, (3) —CN, (4) —CF (5) —C (6) -fluoroC (7) —OC (8) —O-fluoroC (9) heteroaryl selected from pyrazole, thiophene, imidazole, and oxazole, optionally substituted with 1, 2 or 3 substitutents independently selected from methyl, and halo, (10) —NH—OCH (11) phenyl, (12) —O-phenyl, (13) pyridine, (14) —O-pyridine, (15) —NH—C(O)—NH—CH (16) —NH—C(O)—C (17) —NH—C(O)—C (18) —C (19) —C (20) —C(O)—NH (21) —C(O)—C (22) —C(O)—NH—C (23) —C(O)—OH, (24) —C(O)—O—C (25) —C (26) —C (27) —O—S(O) (28) —S(O) (29) —S(O) R wherein the heteroaryl, aryl, heterocycle and cycloalkyl of choices (d), (e) (f), (g), (h), (i), (j), (k), (l), (o) and (p) are optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of (1) hydroxyl, (2) halo, (3) —CN, (4) —CF (5) —C (6) —C (7) —O—CH (8) heteroaryl selected from pyrazole, thiophene, imidazole, and oxazole, optionally substituted with 1, 2 or 3 substitutents independently selected from methyl, and halo, (9) —NH—OCH (10) phenyl, (11) —O-phenyl, (12) pyridine, (13) —O-pyridine, (14) —NH—C(O)—NH—CH (15) —NH—C(O)—C (16) —NH—C(O)—C (17) —C (18) —C (19) —C(O)—NH (20) —C(O)—C (21) —C(O)—NH—C (22) —C(O)—OH, (23) —C(O)—O—C (24) —C (25) —C (26) —O—S(O) R 1 and R 2 are joined so that together with the nitrogen atom to which they are attached there is formed an unsaturated ring of 4, 5, 6 or 7 atoms, said ring optionally containing 1 or 2 additional heteroatoms selected from N and O, and said ring being optionally mono- or di-substituted with substitutents independently selected from (1)oxo, (2) hydroxyl, (3) C (4) —OC (5) —C (6) —Ophenyl (7) —C(O)—NH (8) —CH (9) —CH (10) fluoroC (11) —SO Wherein the phenyl of choices (5) and (6) are optionally mono or di-substituted with substituents independently selected from halo, fluoroC 1-3 alkyl, R