Patent ID: 8309316
Filing Date: 2012-11-13
Classification: C12Q,G01N,Y10S,Y10T

Abstract:
1. A method of profiling a first cell population, said method comprising: contacting each of a first cell population and at least one second cell population with at least two distinguishably detectable activation state-specific binding elements, wherein each said activation state-specific binding element is specific for a state of a signaling node in a cell of said first cell population and a cell of said second cell population; detecting the level of binding of said at least two distinguishably detectable activation state-specific binding elements to their corresponding signaling node state in each of said cell populations to determine the state of each of said signaling nodes in each of said cell populations; comparing the state of each of said signaling nodes in said first cell population with the state of each of said signaling nodes in said at least one second cell population; and producing a profile of said first cell population based on said comparison of the state of each of said signaling nodes in said first cell population to the state of each of said signaling nodes in said second cell population.