Patent ID: 8895732
Filing Date: 2014-11-25
Classification: C07D

Abstract:
1. A method for the chromatographic separation of the enantiomers of a compound of the formula I or an acid-addition salt thereof, wherein said separation of the enantiomers is carried out on a chiral ion exchanger material wherein R R R R A is unbranched or branched alkyl having 1-10 C atoms, wherein 1-7 H atoms may be replaced by F, or cyclic alkyl having 3-7 C atoms; and comprising separating the enantiomers on a chiral ion exchanger which is a) of the structure below wherein X is a counterion determined by the type of buffer salt in the mobile phase and the sphere represents a support, b) of the structure below where the sphere represents a support: or c) contains one of the following structures, a spacer and a support,