Patent ID: 8536118
Filing Date: 2013-09-17
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a lung tumor in a subject, said method comprising administering a c-met antagonist to the subject, whereby the tumor is treated, wherein the antagonist inhibits c-met signaling activity of a human hyperstabilized c-met polypeptide, wherein the hyperstabilized c-met polypeptide comprises a deletion removing a Y1003 phosphorylation site of SEQ ID NO: 17 such that its degradation is diminished compared to wild type c-met, and wherein the hyperstabilized c-met polypeptide has c-met signaling activity and binds c-met ligand, and wherein the c-met antagonist binds the hyperstabilized c-met polypeptide.