Patent ID: 7358393
Filing Date: 2008-04-15
Classification: A61P,C07D,Y02P

Abstract:
1. A method for preparing β-alaninamides of the formula: in which (i) R (ii) R in which R 1 and R 2 are as defined above, or a corresponding salt, with a cyanoacetic ester of the formula: in which R 3 is C 1-10 -alkyl, in a solvent selected from the group consisting of ethanol, N,N-dimethyformamide and mixtures thereof, to give a cyanoacetamide of the formula: in which R 1 and R 2 are as defined above, or a corresponding salt, and, in a second stage, converting the cyanoacetamide of formula (IV), or a corresponding salt, by catalytic hydrogenation to the compound (I), or a corresponding salt.