Patent ID: 7790200
Filing Date: 2010-09-07
Classification: A61K,A61P

Abstract:
1. A controlled release pellet consisting of: a) a water soluble non-pareil core; b) a drug layer applied to the non-pareil core wherein the drug layer consists of: c) a controlled release coating surrounding the drug layer wherein the controlled release coating consists of: d) optionally an immediate release form of metoprolol; wherein, the controlled release pellet exhibits the following dissolution profile when tested in a USP Type 2 apparatus at 75 rpm and 37° C. in a phosphate buffer with a pH of 7.5: 0-40% of the metoprolol is released after 2 hours; 5-50% of the metoprolol is released after 4 hours; 25-80% of the metoprolol is released after 8 hours; and not less than 50% of the metoprolol is released after 16 hours.