Patent ID: 6949517
Filing Date: 2005-09-27
Classification: A61K

Abstract:
1. A method of treating inflammatory conditions comprising administering to a mammal in need thereof an effective amount of a monosaccharide, in which said monosaccharide is substituted by at least three vicinal phosphorus containing radicals of the formula: wherein V T o1 to o3 are independently 0 or 1; n is 0 to 4; U is R Y m1 to m7 are independently 0 to 1; Y and where R i) hydrogen; ii) a straight or branched saturated or unsaturated alkyl group containing 1-22 carbon atoms; iii) a saturated, unsaturated aromatic or non-aromatic homo- or heterocyclic group containing 3-22 carbon atoms and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; iv) a straight or branched saturated or unsaturated alkyl group containing 1-22 carbon atoms substituted with a saturated or unsaturated aromatic or non-aromatic homo- or heterocyclic group containing 3-22 carbon and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; v) an aromatic or non-aromatic homo-or heterocyclic group containing 3-22 carbon and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur which aromatic or non-aromatic homo-or heterocyclic group is substituted with a straight or branched saturated or unsaturated group containing 1-22 carbon atoms; whereby said groups in ii-v are unsubstituted or are substituted by 1-6 of the following groups: hydroxy, alkoxy, aryloxy, acyloxy, carboxy, alkoxycarbonyl, alkoxycarbonyloxy, aryloxycarbonyl, aryloxycarbonyloxy, carbamoyl, fluoro, chloro, bromo, azido, cyano, oxo, oxa, amino, imino, alkylamino, arylamino, acylamino, arylazo, nitro, alkylthio or alkysulfonyl.