Patent ID: 7378232
Filing Date: 2008-05-27
Classification: G01N

Abstract:
1. A method of identifying an agent that modifies the viability of a cell expressing p (pink eyed dilution) protein, the method comprising: (a) contacting control cells expressing a p protein with a toxin and obtaining a measurement of the viability or death of the control cells contacted with the toxin; (b) contacting test cells expressing the p protein with a candidate agent; (c) contacting the agent-contacted test cells with the toxin and obtaining a measurement of the viability or death of the agent-contacted test cells contacted with the toxin, the toxin being different than the agent; (d) comparing the control cell measurement of step (a) to the test cell measurement of step (c); and (e) identifying the agent as a modifier of the viability of a cell expressing p protein, if the test cells, which were contacted with the agent and toxin, are more or less sensitive to the toxin than the control cells, which were not contacted with the agent, when there is a difference between the control cell measurement and the test cell measurement.