Patent ID: 6410548
Filing Date: 2002-06-25
Classification: A61K,C07K

Abstract:
A compound having the formula I: whereinCy2 is benzene or cyclohexane; Q is X is NRb, NSO2Ra, NSO2N(Rb)2, NCORa, or NCON(Rb)2; Y is (CH2)r, CHâ€”C1-8alkyl, or C&boxH;O; R1 is H, C1-8alkyl, CH(Rb)-aryl, or (CH2)nâ€”C5-6cycloalkyl in which aryl is optionally substituted by one or two Rc groups; R2 is H or halo; Ra is Rb, (CH2)nN(Rb)2, (CH2)nN(Rb)C(&boxH;NRd)NRb, (CH2)nNH-2-pyridyl, (CH2)nNH-2-imidazolyl, (CH2)nNH-2-thiazolyl, or Rb is H, C1-8alkyl, (CH2)naryl, C3-6cycloalkyl; or 2 Rb together with the nitrogen atom to which they are attached form a 5- or 6-membered ring optionally containing an additional heteroatom selected from O, S, and NR1; Rc is Rb, halo, ORb, NHSO2Rb, N(Rb)2, CN, NO2, SO2N(Rb)2, SO2Rb, CF3, OCF3; or two Rc groups attached to adjacent carbon atoms together form methylenedioxy; Rd is H, NO2, or CN; Cy is pyridine; n is 0 to 3; m, p and q are independently 0, 1 or 2; r is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.