Patent ID: 6300310
Filing Date: 2001-10-09
Classification: A61K,A61P,C07K,C12N

Abstract:
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:(a) the amino acid sequence shown as residues 1 to 224 in SEQ ID NO:2;(b) the amino acid sequence shown as residues 2 to 224 in SEQ ID NO:2;(c) the amino acid sequence shown as residues 30 to 224 in SEQ ID NO:2;(d) a fragment of the sequence described in (a) wherein a polypeptide consisting of the fragment retains protease inhibiting activity; and(e) the amino acid sequence of a polypeptide which possesses protease inhibiting activity wherein said amino acid sequence is encoded by a polynucleotide which hybridizes to a DNA consisting of a sequence complementary to SEQ ID NO: 1 when incubated in Church buffer with 100 ug/ml denatured herring sperm DNA as a blocking agent followed by washing sequentially with 2.times. SSC/0.1% SDS and 0.2.times. SSC/0.1% SDS at 65.degree. C.