Patent ID: 6214339
Filing Date: 2001-04-10
Classification: A61K

Abstract:
A method for treating otitis externa outer ear infection in dogs and cats, which comprises:administering to an infected outer ear a dosage effective amount of a substantially non-aqueous therapeutic composition in a fluid carrier,said fluid carrier being a member selected from the group consisting of glycerol, propylene glycol, and mixtures thereof, wherein the concentration of the fluid carrier in the therapeutic composition is from about 80 to about 96 wt. % based on the weight of the therapeutic composition,said therapeutic composition comprising, per gram, from about 0.015 to about 0.6 millimole of oxidizable substrate and from about 0.5 to about 500 International Units of an oxidoreductase enzyme specific to said substrate for producing hydrogen peroxide upon administration to the outer ear and further containing from about 0.0001 to about 0.01 millimole of an iodide salt and from about 0.05 to about 20 International Units of peroxidatic peroxidase selected from the group consisting of lactoperoxidase, horse radish peroxidase, iodide peroxidase, myeloperoxidase and mixtures thereof for interacting with hydrogen peroxide to produce a hypoiodite biocidal agent; andlimiting any unbound water present to an amount not more than about 1.0 wt. % based on the weight of the therapeutic composition to stabilize the composition against the production of hydrogen peroxide prior to administering said cccomposition to said outer ear.