Patent ID: 6376534
Filing Date: 2002-04-23
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound according to formula I whereinR1 is selected from any one of (i) a straight or branched C1-C6 alky, C2-C6 alkenyl or C2-C6 alkynyl, where each alkyl, alkenyl or alkynyl may optionally be substituted by one or more aromatic or heteroaromatic substituents; (ii) C3-C7 cycloalkyl optionally substituted by any one of C1-C6 alkyl, C1-C6 alkoxy, or hydroxy; (iii) hydrogen, halogen or C1-C6 alkoxy; (iv) C6-C10 aryl; (v) heteroaryl having from 5 to 10 atoms, each heteroatom being selected from any of S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents Y wherein each Y is as defined below; Q is selected from any of CH3; â€ƒwherein R2, R3 and R4 are each and independently selected from any of (i) C6-C10 aryl; or (ii) heteroaryl having from 5 to 10 atoms, each heteroatom being selected from any of S, N and O; and â€ƒwherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents Y where each Y is as defined below; (iii) hydrogen; (iv) a straight or branched C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; (v) saturated or unsaturated C3-C10 cycloalkyl, optionally and independently substituted by one or more heteroaryls having from 5 to 10 atoms, each heteroatom being selected from any of S, N and O and wherein the heteroaryl may optionally and independently be substituted by 1 or 2 substituents Y wherein each Y is as defined below; Y is each and independently selected from any of hydrogen, CH3; â€”(CH2)p1CF3; halogen; C1-C3 alkoxy; hydroxy; â€”NO2; â€”OCF3; â€”CONRaRb; â€”COORa; â€”CORa; â€”(CH2)p2NRaRb; â€”(CH2)p3CH3; (CH2)p4SORaRb; â€”(CH2)p5SO2Ra; â€”(CH2)p6SO2NRa; C4-C8(alkyl-cycloalkyl) wherein alkyl is C1-C2 alkyl and cycloalkyl is C3-C6 cycloalkyl; 1 or 2 heteroaryls having from 5 to 10 atoms, each heteroatom being selected from any of S, N and O; and oxides; and wherein Ra and Rb are each and independently selected from hydrogen, a branched or straight C1-C6 alkyl, C1-C6 alkenyl, C3-C8 cycloalkyl; and wherein p1, p2, p3, p4, p5 and p6 are each and independently 0, 1 or 2; or a pharmaceutically acceptable salt thereof.