Patent ID: 6669935
Filing Date: 2003-12-30
Classification: A61K,A61P,C12N

Abstract:
A method for inhibiting the growth of a brain tumor in a subject, comprising:administering directly into a carotid artery or vertebral artery in close proximity to the brain tumor, a therapeutically effective amount of a replication-defective retroviral vector comprising a nucleic acid encoding a negative selective marker gene product that converts enzymatically an interacting agent into a cytotoxic agent, thereby selectively transfecting endothelial cells in the vaculature of the brain tumor and the negative selective marker is expressed in the endothelial cells; and administering the interacting agent to the vasculature of the brain tumor, wherein the negative selective marker gene product converts enzymatically the interacting agent to a cytotoxic agent, thereby destroying the endothelial cells in the vasculature of the brain tumor and inhibiting the growth of the brain tumor.