Patent ID: 8476054
Filing Date: 2013-07-02
Classification: A61K,A61P,C12N

Abstract:
1. A composition comprising an isolated hemocoagulase of Agkistrodon acutus, the isolated hemocoagulase consisting of an alpha subunit and a beta subunit, which are linked by seven disulfide bonds, wherein the alpha subunit consists of the 129 amino acids as set forth in SEQ ID No. 1, and the beta subunit consists of the 123 amino acids as set forth in SEQ ID No. 2, wherein the hemocoagulase has a molecular weight, as determined by sequence analysis, of about 29.3 kD to about 29.5 kD and an isoelectric point of about 5.5, wherein the isolated hemocoagulase constitutes more than 95% of the composition.