Patent ID: 6706478
Filing Date: 2004-03-16
Classification: C12Q,G01N,Y10T

Abstract:
A method for detecting whether a subject is suffering from or is perdisposed to developing a disease or condition associated with an IL-1 inflammatory haplotype, comprising detecting one or more alleles selected from the group consisting of: allele 4 of the 222/223 marker of IL-1A, allele 4 of the gz5/gz6 marker of IL-1A, allele 1 of the âˆ’889 marker of IL-1A, allele 1 of the +3954 marker of IL-1B, allele 2 of the âˆ’511 marker of IL-1B, allele 3 of the gaat.p33330 marker, allele 3 of the Y31 marker, allele 2 of +2018 of IL-1RN, allele 1 of +4845 of IL-1A, allele 3 of the 222/223 marker of IL-1A, allele 3 of the gz5/gz6 market of IL-1A, allele 2 of the âˆ’889 marker of IL-1A, allele 2 of the +3954 marker of IL-1B, allele 1 of the âˆ’511 marker of IL-1B, allele 4 of the gaat.p33330 marker, allele 6 of the Y31 marker, allele 1 of +2018 of IL-1RN, allele 2 of +4845 of IL-1A, and allele 1 of the VNTR marker of IL-1R, wherein the presence of said one or more alleles indicates that the subject is predisposed to the development of or has the disease or condition.