Patent ID: 8834913
Filing Date: 2014-09-16
Classification: A61K,A61L,A61P

Abstract:
1. A medical implant device comprising: a device substrate having a surface; a silane derivative coating comprising a terminal amine, wherein the silane derivative coating is covalently bonded to the surface; a bioactive agent; and a hetero-bifunctional polyethylene glycol spacer comprising a carboxyl group and an amine group; wherein the spacer is between the silane derivative coating and the bioactive agent, the carboxyl group of the polyethylene glycol spacer being covalently bonded to the terminal amine of the silane derivative coating through a peptide bond and the amine group of the polyethylene glycol spacer being covalently bonded to the bioactive agent through a peptide bond; wherein the silane derivative coating is first bonded to the surface before bonding to the polyethylene glycol spacer.