Patent ID: 8613776
Filing Date: 2013-12-24
Classification: A61L

Abstract:
1. A biocompatible skin substitute, comprising: a gel first layer having a top surface and a bottom surface, a thickness of the gel first layer being from the top surface to the bottom surface, a length of the gel first layer being in a direction perpendicular to said thickness, the thickness being less than said length, the gel first layer including a plurality of substantially discontinuous cylindrical zones, each zone extending entirely through the thickness of the gel first layer from the top surface to the bottom surface; the zones being substantially regularly spaced and having a mean diameter of between 70 and 120-μm such that the gel first layer has a void fraction between 20% and 60%; an average density of fibers in each zone being lower than an average density of fibers in the gel first layer between the zones; an average distribution of fibers in the gel first layer being uniform across the thickness of the gel first layer; and the fibers including collagen and a glycosaminoglycan containing chondroitin-6-sulfate, wherein the respective densities of the fibers in the zones and between the zones permits freer migration of human epithelial dermal cells into the zones than between the zones.