Patent ID: 6822000
Filing Date: 2004-11-23
Classification: A61K,A61L,C08G

Abstract:
A pharmaceutical composition comprising:(a) an active agent; and (b) as a vehicle, a poly(orthoester) that is the product of a reaction between: (i) a diketene acetal of formula II: where:R is a bond, â€”(CH2)aâ€”, or â€”(CH2)bâ€”Oâ€”(CH2)câ€”; where a is an integer of 1 to 10, and b and c are independently integers of 1 to 5; and L is hydrogen or a C13 alkyl, and (ii) a polyol or mixture of polyols in which at least 0.1 mole percent of the total polyol content is a diol of the formula HOâ€”R1â€”OH, where R1 is: where:p is an integer of 1 to 20; R5 is hydrogen or C1-4 alkyl; and R6 is: where:s is an integer of 0 to 30; t is an integer of 2 to 200; and R7 is hydrogen or C1-4 alkyl.