Patent ID: 6699870
Filing Date: 2004-03-02
Classification: A61P,C07D

Abstract:
A phthalazine compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a hydroxyl group, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group;X represents a cyano group, a nitro group, a halogen atom, a thiocarbamoyl group, a hydroxyimino group which may be substituted with a C1 to C4 alkyl group, a phenyl C1 to C4 alkyl group or a carboxy C1 to C4 alkyl group, or a heteroaryl group selected from the group consisting of pyrazole, triazole, tetrazole, thiazole, and thiophene which may be substituted with 1 to 3 substituent groups selected from the following substituent group A; Y represents: i) a group represented by the formula (V): â€ƒwherein M represents a single bond or a C1 to C4 alkylene group which may be substituted with a hydroxyl group, carboxyl group, a C1 to C4 alkyl group or a C1 to C4 alkoxy group, ring K represents a 5- to 8-membered amine ring formed together with M, and ring L represents a 5- to 8-membered alkyl ring which may have a substituent group selected from the group consisting of hydroxyl; carboxyl; carboxyl having a protective group which can be degraded by any means in vivo to form a carboxylic acid; a C1 to C4 alkyl group, a C1 to C4 alkyl group substituted with a hydroxyl group, a carboxyl group or a halogen atom and may have oxygen in the ring L; ii) a group represented by the formula (VI): â€ƒwherein ring P represents a 5- to 7-membered amine ring, and R5 represents a hydrogen atom or a C1 to C4 alkyl group which may be substituted with a halogen atom, a hydroxyl group or a carboxyl group; and 1 is an integer of 1 to 3.