Patent ID: 7462717
Filing Date: 2008-12-09
Classification: A61P,C07D

Abstract:
1. A compound according to the general Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof or the N-oxide form thereof, wherein: X is CH R R Ar is phenyl or naphthyl, optionally substituted with one or more halo, cyano, oxo, hydroxy, alkyl, formyl, alkyloxy or amino radicals; Het is a heterocyclic radical selected from the group consisting of Het Het Het Het a and b are asymmetric centers; (CH Pir is a radical according to any one of Formula (IIa), (IIb) or (IIc)  optionally substituted with n radicals R R alkyl represents a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, optionally substituted with one or more halo, cyano, oxo, hydroxy, formyl or amino radicals and alkenyl represents a straight or branched unsaturated hydrocarbon radical having one or more double bonds, optionally substituted with one or more halo, cyano, oxo, hydroxy, formyl or amino radicals.