Patent ID: 7393933
Filing Date: 2008-07-01
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A monoclonal antibody which binds to an epitope of two or more HBsAg variants, wherein said epitope comprises the mutations selected from the group consisting of: (a) Met to Ile at amino acid 133, Phe to His at amino acid 134, and Asp to Val at amino acid 144 of NP HBsAg; (b) Met to Ile at amino acid 133, Phe to Asn at amino acid 134, Pro to Ser at amino acid 142, Ser to Leu at amino acid 143, and Gly to Lys at amino acid 145 of MAM HBsAg; and (c) Ser to Met at amino acid 143 of SP HBsAg.