Patent ID: 6284777
Filing Date: 2001-09-04
Classification: A61P,C07C,C07D,C12N,C12Q,G01N

Abstract:
A compound according to Formula IV: ##STR63##wherein:R.sup.21 and R.sup.26 are independently C.sub.5-6 alkyl; C.sub.2-6 alkenyl; C.sub.3-11 cycloalkyl;T-C.sub.3 - .sub.6 alkyl; V-C.sub.1-6 alkyl; T-C.sub.2-6 alkenyl; orT-(CH.sub.2).sub.n CH(T)(CH.sub.2)N; optionally substituted by one ortwo halogens, SR.sup.20, OR.sup.20, NR.sup.20 R.sup.27 or C.sub.1-4 alkyl;R.sup.27 is R.sup.28 CO, or R.sup.28 OCO;R.sup.28 is C.sub.1-6 alkyl; C.sub.3-11 cycloalkyl; Ar; Het; T-C.sub.1-6 alkyl; orT-(CH.sub.2).sub.n CH(T)(CH.sub.2).sub.n ; optionally substituted by one or two halogens,SR.sup.20,OR.sup.20, NR.sup.20 R.sup.73,or C.sub.1-6 alkyl;R.sup.20, R.sup.22, R.sup.23, R.sup.24, R.sup.25, and R.sup.73 are independently H, C.sub.1-4 alkyl, Ar-C.sub.0-6 alkyl, orHet-C.sub.0-6 alkyl;R.sup.58 and R.sup.59 are independently H, C.sub.1-6 alkyl, Ar-C.sub.0-6 alkyl, or Het-C.sub.0-6 alkyl;T is Ar, or Het;V is C.sub.3-7 cycloalkyl;n is 1 to 6:Ar is phenyl or naphthyl, optionally substituted by one or more ofPh-C.sub.0-6 alkyl, Het-C.sub.0-6 alkyl, C.sub.1-6 alkoxy, Ph-C.sub.0-6 alkoxy,Het-C.sub.0-6 alkoxy, OH, (CH.sub.2).sub.1-6 NR.sup.58 R.sup.59, orO(CH.sub.2).sub.1-6 NR.sup.58 R.sup.59 ;or a pharmaceutically acceptable salt, hydrate or solvate thereof.