Patent ID: 8470800
Filing Date: 2013-06-25
Classification: A61K,A61P,C07H

Abstract:
1. A method of reducing intraocular pressure (IOP) in a human in need thereof, comprising the step of: applying an effective amount of a compound according to Formula I or a pharmaceutically acceptable salt thereof, to an affected eye of a human, wherein A is —CH B and C are —OH; D is A and B are trans with respect to each other; B and C are cis with respect to each other; C and D are cis or trans with respect to each other; R R R R R wherein -3- to 7-membered monocyclic heterocyclyl is a 3- or 4-membered non-aromatic monocyclic cycloalkyl in which 1 of the ring carbons has been replaced with an NH, an O, or an S moiety; or a 5-, 6-, or 7-membered aromatic or non-aromatic monocyclic cycloalkyl in which 1-4 of the ring carbons have been independently replaced with an NH, an O, or an S moiety, wherein -8- to 12-membered bicyclic heterocyclyl is a bicyclic 8- to 12-membered aromatic or non-aromatic bicyclic cycloalkyl in which one or both of the rings of the bicyclic ring system have 1-4 of its ring carbons independently replaced with an NH, an O, or an S moiety, and each n is independently an integer ranging from 1 to 5, and a pharmaceutically acceptable vehicle.