Patent ID: 9176064
Filing Date: 2015-11-03
Classification: C07D,C07K,C09B,C12N,C12Q,G01N

Abstract:
1. A bisubstrate fluorescent probe which binds to protein kinase CK2 (casein kinase 2) with affinity KD=0.02-10 nm and wherein fragment X is 1H-benzimidazol or substituted 1H-benzimidazol, j is from 1 to 10, i is from 1 to 10, R 1 and R 2 are independently H or —(CH 2 ) n COOH, n is independently 0 to 3, at least one of R 1 and R 2 is —(CH 2 ) n COOH, and the α-carbon connected to R 2 is independently in either R or S configuration, FL is a fluorescent label, and L is a linker formed of a hydrocarbon chain.