Patent ID: 6395742
Filing Date: 2002-05-28
Classification: A61P,C07D

Abstract:
A compound having the formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, whereinAlk is C1-6alkanediyl or C3-6alkenediyl; R1 is hydrogen or C1-4alkyl; R2 and R3 each independently are hydrogen, C1-6alkyl or C3-7cycloalkyl; or R2 and R3 may also be taken together with the nitrogen atom to which they are attached, thus forming a pyrrolidine, a piperidine or a perhydro azepine ring; R4 is hydrogen or halo; Q is aryl, aryloxy, di(aryl)methyl or heteroaryl; aryl is naphthyl or phenyl, said naphthyl and phenyl may optionally be substituted with one, two or three substituents selected from halo, hydroxy, C1-4alkyl, C1-4alkyloxy, C1-4alkylcarbonyl, haloC1-4alkyl, nitro, amino, cyano and phenyl; and heteroaryl is quinolinyl, isoquinolinyl, pyridinyl, thienyl, indolyl, [2,3-dihydro-1,4-benzodioxinyl, 2,3-dihydro-benzofuranyl]2,3-dihydro-benzofuran-3-yl, 2,3-dihydro-benzofuran-4-yl, 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-benzofuran-6-yl, 2,3-dihydro-benzofuran-7-yl or benzodioxolanyl; said heteroaryls may optionally be substituted with one, two or three substituents selected from halo, hydroxy, C1-4alkyl, C1-4alkyloxy, C1-4alkylcarbonyl, haloC1-4alkyl and phenyl.