Patent ID: 6069156
Filing Date: 2000-05-30
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR14## wherein R.sup.1 is hydrogen, halogen, nitro, acyl, cyano, hydroxyimino(lower)alkyl, lower alkenyl optionally substituted with oxo, or lower alkyl optionally substituted with hydroxy;R.sup.2 is hydrogen, halogen, lower alkenyl, acyl, or lower alkyl optionally substituted with protected carboxy, carboxy, lower alkoxy or hydroxy;R.sup.3 is lower alkenyl, or lower alkyl substituted by(1) aryl optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, lower alkoxy, lower alkylenedioxy, cyano, nitro, carboxy, protected carboxy, acyl, and amino optionally substituted with acyl or protected carboxy, or(2) a heterocyclic group selected from the group consisting of pyridyl, thienyl, benzothiazolyl, and benzothiophenyl, each of which is optionally substituted with halogen; andR.sup.4 is acyl, cyano, halogen, a heterocyclic group, amino optionally substituted with acyl or protected carboxy, or lower alkyl optionally substituted with protected carboxy, carboxy or acyl or as defined above; orR.sup.1 and R.sup.2 together with the carbon atoms to which they are attached, represent a 4- to 7-membered carbocyclic ring optionally substituted with oxo;or a pharmaceutically acceptable salt thereof.