Patent ID: 7943574
Filing Date: 2011-05-17
Classification: A61P,C07K

Abstract:
1. A method of inhibiting apoptosis in a neuronal cell or a pancreatic cell, comprising contacting said cell with a chimeric peptide less than 50 amino acids in length, wherein the peptide comprises a first domain and a second domain linked by a covalent bond, wherein said first domain comprises the amino acid sequence of SEQ ID NO:38 and the second domain comprises the amino acid sequence of SEQ ID NO:2, wherein Xaa at the amino acid residue positions 2 and 6 can be any single amino acid, Xaa at the amino acid residue 3 position can be either serine or proline, Xaa at the amino acid residue 5 position can be either glycine or leucine, and wherein said chimeric peptide inhibits the binding of mitogen-activated protein kinase-7 (MKK7) to insulin binding protein 1 (IB1) or insulin binding protein 2 (IB2).