Patent ID: 6686440
Filing Date: 2004-02-03
Classification: A61K,A61Q,C07C,C08G

Abstract:
A method or preparing a derivative of a copolymer containing copolymerized aspartate units and succinimide units which comprises:heating to polymerize a comonomer mixture of aspartic acid and a salt of aspartic acid, which comonomer mixture was prepared by drying a solution of salt of aspartic acid having a cation which does not volatilize during the drying and a salt of aspartic acid having a cation which at least partially volatilizes to free aspartic acid during the drying to form a copolymer; derivatizing said copolymer by reacting an amino group-containing compound, â€”OH group-containing compound or other nucleophilic group-containing compound with at least one succinimide unit of the copolymer; wherein said derivatizing is conducted in an aqueous solution, an organic solvent or a mixture thereof.