Patent ID: 6022307
Filing Date: 2000-02-08
Classification: C07D,C07F

Abstract:
A compound of general Formulae (I), (II), (III) and (IV), ##STR129## wherein: in general Formulae (I), and (II);R.sup.1 is a moiety selected from the group: ##STR130## Y is sulfur, oxygen, nitrogen or carbon; R.sup.4a, R.sup.4b, R.sup.4c, R.sup.4d, R.sup.4e, R.sup.4f and R.sup.4e are independently selected from hydrogen, hydroxy, amino, halogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, hydroxyalkyl of 2 to 6 carbon atoms, trifluoromethyl, cyano, nitro, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, alkylcarbonylamino of 1 to 6 carbon atoms, thiol, alkylthio of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, --N(R.sup.4h)(R.sup.4i), phenyl, phenylamino, and carboxaldehyde;R.sup.4h and R.sup.4i, independent from each other, are straight chain alkyl of 1 to 6 carbon atoms;R.sup.5a, R.sup.5b, R.sup.5c, R.sup.5d, and R.sup.5e are independently selected from hydrogen, hydroxy, amino, halogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, hydroxyalkyl of 2 to 6 carbon atoms, cyano, nitro, alkylamino of 1 to 6 carbon atoms, and --N(R.sup.4h)(R.sup.4i);R.sup.6a and R.sup.6b are independently selected from hydrogen, halogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkenyl of 2 to 6 carbon atoms, and alkynyl of 2 to 6 carbon atoms;R.sup.6c is hydrogen, methyl, cyano, halogen;R.sup.7a, R.sup.7b and R.sup.7c are independently selected from hydrogen, hydroxy, amino, halogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, hydroxyalkyl of 2 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, cyano, nitro, alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, and --N(R.sup.4h)(R.sup.4i);R.sup.8 is hydrogen, hydroxy, amino, straight chain alkyl of 1 to 6 carbon atoms or branched chain alkyl of 3 to 7 carbon atoms;R.sup.9, R.sup.10, R.sup.11a and R.sup.11b are independently hydrogen or alkyl of 1 or 2 carbon atoms;R.sup.12a and R.sup.12b are independently hydrogen, straight chain alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 4 carbon atoms, hydroxyalkyl of 2 to 4 carbons, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thiol, alkylthio of 1 to 4 carbon atoms, alkylamino of 1 to 4 carbon atoms, --N(R.sup.12c)(R.sup.12d); or trifluoromethyl;R.sup.12c and R.sup.12d, independent from each other, are straight chain alkyl of 1 to 4 carbon atoms;R.sup.13 is independently hydrogen, alkyl of 1 or 2 carbon atoms, hydroxy, amino, halogen, hydroxymethyl, or aminomethyl;R.sup.14 is hydrogen, alkyl of 1 or 2 carbon atoms, or halogen;R.sup.15 is hydrogen or cyano;R.sup.16 is a moiety selected from the group: ##STR131## in general formula (III): R.sup.2a and R.sup.2b are independently hydrogen, straight chain alkyl of 1 to 6 carbon atoms optionally substituted with trifluoromethyl, branched chain alkyl of 3 to 8 carbon atoms or benzyl with the proviso that each independent R.sup.2a and R.sup.2b may not simultaneously be hydrogen or a pharmaceutically acceptable salt;R.sup.1, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.4d, R.sup.4e, R.sup.4f, R.sup.4g, R.sup.4h, R.sup.4i, R.sup.5a R.sup.5b, R.sup.5c, R.sup.5d, R.sup.5e, R.sup.6a, R.sup.6b, R.sup.6c, R.sup.7a, R.sup.7b, R.sup.7c, R.sup.8, R.sup.9, R.sup.10, R.sup.11a, R.sup.11b, R.sup.12a, R.sup.12b, R.sup.12c, R.sup.12d, R.sup.13, R.sup.14, R.sup.15, R.sup.16 and Y are as defined for general Formulae (I), and (II);in general formula (IV):R.sup.1a is a moiety selected from the group: ##STR132## R.sup.4a, R.sup.4b, R.sup.4c, R.sup.4h, R.sup.4i, R.sup.6a, R.sup.6b, R.sup.6c, R.sup.7a, R.sup.7b, R.sup.7c, R.sup.8, R.sup.9, R.sup.10, R.sup.11a, R.sup.11b, R.sup.12a, R.sup.12b, R.sup.12c, R.sup.12d, R.sup.13, R.sup.14, R.sup.15, R.sup.16 and Y are as defined for general Formulae (I), (II) and (III); with the proviso that R.sup.15 is not H when R.sup.6 is phenyl;alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, alkylcarbonylamino of 1 to 6 carbon atoms, are defined where 1 to 6 carbon atoms describes the length of the alkyl or alkoxy as bonded to the carbonyl carbon;or a pharmaceutically acceptable salt of Formulae (I), (II), (III) and (IV) thereof.