Patent ID: 8455554
Filing Date: 2013-06-04
Classification: A61K,B01J,B82Y,C01B,C01F,C01G,C01P,C04B

Abstract:
1. A process for encapsulation of water-insoluble particles in a hydrated metal oxide or a mixture of hydrated metal oxides, comprising: a) preparing a metal alkoxide solution of one or several metal alkoxides in an alcohol which is miscible with water without phase separation; b) preparing a particle suspension in an aqueous solvent having a pH of from pH 0 to pH 7; c) mixing the solution of step a) and the suspension of step b) in a volume or weight proportion suitable for forming a suspension of said particles in a single-phase aqueous sol colloid of hydrated metal oxide(s); and d) storing said aqueous sol colloid particle suspension for a period of time sufficient to provide for formation and self-assembly of micelles of metal oxide(s) on the particles so as to form shells of hydrated metal oxide(s) on the particles, wherein the storage time can be selected to allow for transition of the aqueous sol to an aqueous gel; e) optionally removing water and/or solvent from the product of step d) to form aggregates of water-insoluble particles in shells of hydrated metal oxide(s); f) alternatively to step e), optionally separating the particles enclosed in shells of hydrated metal oxide(s) obtained in step d) from other components; and g) optionally removing water and alcohol from the product of step f); with the proviso that the process does not comprise the use of a surfactant.