Patent ID: 9068020
Filing Date: 2015-06-30
Classification: A61K,A61P,C07K

Abstract:
1. A method of inducing a cytotoxic T lymphocyte (CTL) response in a human subject, the method comprising administering to the subject an effective amount of a composition comprising an isolated immunogen of 9 to 50 amino acid residues comprising a peptide consisting of the amino sequence set forth in SEQ ID NO:1 with four or fewer amino acid substitutions within SEQ ID NO:1, wherein the four or fewer amino acid substitutions do not occur at position 2 or position 8 of SEQ ID NO:1, wherein the peptide is a CD133 HLA-A2 restricted epitope, and wherein the administration of the composition comprising the isolated immunogen elicits a peptide-specific CTL response to cells expressing HLA-A2 and presenting the peptide.