Patent ID: 6605624
Filing Date: 2003-08-12
Classification: A61K

Abstract:
A compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein:the compound corresponds in structure to the following generic formula: as to R2 and R6: R2 and R6 are independently selected from the group consisting of hydrogen, hydroxy, alkyl, fluorinated alkyl, fluorinated aralkyl, chlorofluorinated alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkoxy, alkoxyalkyl, and alkoxycarbonyl; at least one of R2 and R6 is selected from the group consisting of fluorinated alkyl, chlorofluorinated alkyl, and alkoxyalkyl; if R4 is aryl, and one of R2 and R6 is trifluoromethyl, then the other of R2 and R6 is difluoromethyl; R3 is â€”CO2R7; R4 is selected from the group consisting of hydrogen, hydroxy, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heteroarylalkyl, alkoxy, thio, trialkylsilyl, alkylamino, OP(O)(O R10)2, and â€”OC(O)N(R8)2; R7 is alkyl; R8 is aryl; each R10 is alkyl; as to R5: R5 is selected from the group consisting of cycloalkylthioalkyl, arylthioalkyl, heteroarylthioalkyl, â€”SR45, if R4 is alkyl, cycloalkyl, or cycloalkylalkyl, then R5 is other than â€ƒwherein R16b is alkyl and R15b is alkylthio; R15b is selected from the group consisting of alkylthio and alkylsulfonyloxy; R16b is selected from the group consisting of alkyl, alkenyl, aryl, and heteroaryl; R17 is alkyl; R18 is alkyl; R19 is â€”SR20; R20 is selected from the group consisting of aryl, heteroaryl, and aminoalkyl; R28 is alkyl; R29 is alkyl; as to R37 and R38: R37 is selected from the group consisting of hydrogen, alkoxy, and alkylthio; R38 is selected from the group consisting of haloalkyl, cycloalkyl, heterocyclylalkoxy, and alkylthio; at least one of R37 and R38 is alkylthio; R45 is selected from the group consisting of hydrogen, haloalkyl, heterocyclyl, aryalkyl, heteroaralkyl, alkylthioalkyl, aminocarbonylalkyl, â€”SR46, and â€”CH2R47; R46 is selected from the group consisting of aryl and heteroaryl; R47 is selected from the group consisting of methylenedioxyphenyl, pyridyl, quinolinyl, tetrahydronaphthyl, and benzodioxanyl; R48 is selected from the group consisting of hydrogen and alkyl; R49 is selected from the group consisting of alkoxy and haloalkyl; R50 is selected from the group consisting of alkyl, alkoxy, and heteroaryl; and R51 is haloalkyl.