Patent ID: 6107284
Filing Date: 2000-08-22
Classification: A61P,C07H

Abstract:
A compound of formula I ##STR37## wherein R is an acyl group of the formulaA--Z--CH.sub.2 --COwherein A is substituted or unsubstituted phenyl, benzyl, napthyl or heteroaryl;wherein Z is selected from the group consisting of oxygen, sulfur, an SO.sub.2 group, and a linear or branched C.sub.1 -C.sub.4 alkylene,said substituted aryl substituted with up to five substituents, each independently selected from the group consisting of halogens, linear or cyclic C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, methylenedioxy, OCF.sub.3, CF.sub.3, NO.sub.2, CN, OCH.sub.2 Aryl, OH, OPO.sub.3 H.sub.2, CH.sub.2 OP.sub.3 H.sub.2, PO.sub.3 H.sub.2, OCH.sub.2 CO.sub.2 H, COOH, CH.sub.2 COOH, COCH.sub.3 and CHO groups; andR' is selected from the group consisting of carbamates of the formula --CO--N--(R.sub.1 R.sub.2) where N(R.sub.1 R.sub.2) represents aminodiacetic groups, polycyclic amines, H.sub.2 O.sub.3 P--CH.sub.2 --CO, C(O)CH.sub.2 OCH.sub.2 CO.sub.2 H, C(O)CH.sub.2 SO.sub.2 CH.sub.2 COOH, and phosphate monoesters;or a therapeutically acceptable salt thereof.