Patent ID: 6407106
Filing Date: 2002-06-18
Classification: A61P,C07D

Abstract:
A compound corresponding to the formula I: whereinR1 is hydrogen or lower alkyl, R2 is lower alkyl, di-lower-alkylamino lower alkyl, lower-alkoxycarbonyl lower alkyl; cyclo(hetero)alkyl having 5-6 ring atoms, which may optionally be substituted once or twice by lower alkyl and which optionally contains 1-2 double bonds; (hetero)phenyl lower alkyl optionally substituted once or twice in the (hetero)phenyl ring by halogen, lower alkyl and/or lower alkoxy, the lower-alkyl chain of which (hetero)phenyl lower alkyl is optionally substituted once or twice by lower alkyl or by spiro-C4-C5-alkylene; or phenyl lower alkoxy optionally substituted once or twice in the phenyl ring by halogen, lower alkyl and/or lower alkoxy, and R3 is lower alkyl, lower-alkoxycarbonyl lower alkyl or cyclo(hetero)alkyl with 5-6 ring atoms which is optionally substituted once or twice by lower alkyl, or R2 and R3, together with the nitrogen to which they are bonded, form a cyclic group of formula a: â€ƒwherein A is nitrogen, oxygen, methylene or methylidene, the double bond of which, together with the adjacent carbon, is formed in position 3 of group a, n is a whole number from 1 to 3, R4 is hydrogen, lower alkyl, lower-alkoxy lower alkyl, lower alkoxycarbonyl, lower-alkoxycarbonyl lower alkyl, di-lower-alkylamino lower alkyl; (hetero)phenyl optionally substituted once or twice by halogen, lower alkyl and/or lower alkoxy; (hetero)phenyl lower alkyl optionally substituted once or twice in the (hetero)phenyl ring by halogen, lower alkyl and/or lower alkoxy, the lower-alkyl chain of which (hetero)phenyl lower alkyl is optionally substituted once or twice by lower alkyl; cyclo(hetero)alkyl with 5-6 ring atoms, or cyclo(hetero)alkyl lower alkyl, the cyclo(hetero)alkyl group of which has 5-6 ring atoms, and R5 is hydrogen, lower alkyl or lower-alkoxy lower alkyl, or R4 and R5 together are spiroethylenedioxy bonded to a carbon of group a; C3-C4-alkylene bonded to two adjacent atoms of group a; or phenyl fused via two adjacent carbons of group a, or R2 and R3, together with the nitrogen to which they are bonded, form a pyrrolidine ring which is substituted twice by C4-alkylene which is bonded each time via two adjacent carbon atoms, or a physiologically compatible acid addition salts thereof.