Patent ID: 6821980
Filing Date: 2004-11-23
Classification: A61K,A61P,C07D

Abstract:
A compound selected from the group consisting of compounds of the formula in whichR1 is C2-C3 alkyl; R2 is phenyl, naphthyl or heterocyclyl bonded via one of its C atoms, where the heterocyclyl and phenyl, groups are unsubstituted or mono- or polysubstituted by halogen, cyano, alkyl, alkoxy, hydroxyl, nitro, amino, alkylamino, dialklamino, alkanoylamino, formyl, alkanoyloxy, cyanoalky, cyanoalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, hydroxyalkylamino, alkoxyalkoxy, carbamoylalkoxy, alkylaminoalkyl, dialkylaminoalkyl halogenoalkylaminoalkyl, N-alkyl-N-halogenoalky-aminoalkyl, alkylsulphanyl (alkylthio), alkylsulphinyl, alkylsulphonyl, alkylsulphonyloxy, alkylsulphonylamino, R7, R7-alkyl, R7-alkoxy, R7-carbonylalkoxyalkyl or R7-alkanoylamino, or are also substituted by two adjacent substituents which together form a fused-5- or 6-membered heteromylic radical; and R7 is heterocyclyl or alkyl containing up to 6 carbon atoms; and where the napthyl group is unsubstituted or mono- or polyhydroxysubstituted; and R3 is C2-C6 alkyl, C2-C6 alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulphonyl, phenylsulphonyl, cycloalkylsulphonyl, cycloalkylalkylsulphonyl, cycloalkylalkylsulphamoyl, heterocyclylsulphonyl, heterocyclylallylsulphonyl or dialkylsulphamoyl, where the cycloalkyl, cycloalkylalkyl, heterocyclyalkyl, cycloalkylsulphonyl, cycloalkalkysulphonyl, heterocyclylsulphonyl, heterocyclylalkylsulphonyl, phenylsulphonyl or cycloalkylalkylsulphamoyl substituents are unsubstituted or substituted with alkyl, alkoxy, bydroxyalkyl, alkoxyalkyl, cyano, cyanoalkyl or cyanoalkenyl; wherein alkl, alkoxy and alkenyl can contain up to 6 carbon atoms, and where the C2-C6 alkyl, C2-C6 alkenyl, alkylsulphonyl and dialkylsulphamoyl substituents are unsubstituted or substituted by haldgen, cyano, hydroxyl or alkoxy having up to 6 carbon atoms; and with heterocyclyl being a 5 or 6 membered heterocyclic ring containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen or sulfur; and acid addition salts of these compounds.