Patent ID: 6426355
Filing Date: 2002-07-30
Classification: C07D

Abstract:
A compound having the formula: whereinR1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, â€”CN, â€”NO2, â€”CO2R6, â€”COR6, â€”OR6, â€”SR6, â€”SOR6, â€”SO2R6, â€”CONR7R8, â€”NR6N(R7R8), â€”N(R7R8) or Wâ€”Yâ€”(CH2)nâ€”Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is â€”(CO)â€” or â€”(CO2)â€”, or is absent; Z is alkyl of 1 to 4 carbon atoms, â€”CN, â€”CO2R6, COR6, â€”CONR7R8, â€”OCOR6, â€”NR6COR7, â€”OCONR6, â€”OR6, â€”SR6, â€”SOR6, â€”SO2R6, SR6N(R7R8), â€”N(R7R8) or phenyl; G is isothiazolyl, pyrazolyl, isoxazolyl, oxazolyl, thienyl, pyrrolyl, thiadiazolyl, furyl, oxazolyl or imidazolyl; X is a bond, â€”NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6.