Patent ID: 9046536
Filing Date: 2015-06-02
Classification: A61K,A61P,G01N,Y10T

Abstract:
1. A method of identifying a tissue factor pathway inhibitor (TFPI)-inhibiting compound which is capable of enhancing blood coagulation, the method comprising: contacting a first portion of a plasma sample comprising TFPI with an antibody which inhibits TFPI activity; measuring peak thrombin generation or peak time of the first portion of plasma sample; contacting a second portion of the plasma sample comprising TFPI with a composition comprising a sulfated polysaccharide having a fucose content of 60% or greater; measuring peak thrombin generation or peak time in the second portion of plasma sample; and comparing the peak thrombin generation or peak time of the second portion of plasma sample with the peak thrombin generation or peak time of the first portion of plasma sample, wherein no difference in peak thrombin generation or peak time between the second portion of plasma sample compared to the first portion of plasma sample indicates that the sulfated polysaccharide is a TFPI-inhibiting compound.