Patent ID: 6207417
Filing Date: 2001-03-27
Classification: A61K,A61P,C07K,Y02A,Y10S

Abstract:
An isolated DNA sequence for use in securing expression in a procaryotic or eukaryotic host cell of a polypeptide product having an amino acid sequence sufficiently duplicative of that of naturally-occurring non-human stem cell factor to allow possession of a hematopoietic biological activity of naturally occurring stem cell factor, said DNA sequence selected from among:(a) DNA sequences set out in FIG. 14B, FIG. 14C or their complementary strands;(b) DNA sequences which hybridize to the DNA sequences defined in (a) or fragments thereof, the polypeptide fragment encoded by said DNA possessing hematopoietic biological activity;(c) DNA sequences differing from the isolated DNAs of (a) or (b) in nucleotide sequence due to the degeneracy of the genetic code, and which encode a polypeptide product having a hematopoietic biological activity.