Patent ID: 6025385
Filing Date: 2000-02-15
Classification: A61P,C07D

Abstract:
A taxane derivative represented by the following formula (1): ##STR119## wherein at least one of X and Y represents a group --CO--A--B in which A represents a single bond, a group --R--CO--, a group --R--OCO-- or a group --R--NHCO--, R representing a lower alkylene group or a phenylene group, B represents a group ##STR120## in which R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or an aralkyloxycarbonyl group, a group ##STR121## in which R.sup.2 represents an amino group, a mono or di-alkylamino group, a piperidino group, a pyrrolidino group or a morpholino group, or a group ##STR122## in which R.sup.3, R.sup.5 and R.sup.6 each independently represent a hydrogen atom or a lower alkyl group and R.sup.4 represents a lower alkylene group, and the other represents a hydrogen atom, a lower alkanoyl group, a benzoyl group, an alkoxycarbonyl group or a trihalogenoalkoxycarbonyl group; Z represents a hydrogen atom, a trialkylsilyl group or a trihalogenoalkoxycarbonyl group; Ac represents an acetyl group, Bz represents a benzoyl group, and Ph represents a phenyl group; or a salt thereof.