Patent ID: 8399005
Filing Date: 2013-03-19
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising a NO donor and a silver-based therapeutic agent, wherein the NO donor comprises a NO-releasing macromolecular scaffold and wherein the NO-releasing macromolecular scaffold is a nanoparticle or microparticle comprising a matrix material that releases nitric oxide, wherein said matrix material comprises a co-condensed silica network and said silver-based therapeutic agent is selected from the group consisting of silver sulfadiazine, silver nitrate, silver bromide, silver sulfate and combinations thereof, and wherein the NO donor and the silver-based therapeutic agent exhibit a superadditive effect wherein the combination of the NO donor and the silver-based therapeutic agent is more effective than would be expected based on adding the therapeutic effects observed with the NO donor and silver-based therapeutic agent individually.