Patent ID: 9173843
Filing Date: 2015-11-03
Classification: A61K,A61P,H04R

Abstract:
1. A method for producing crystalline microparticles of a hydrophobic active substance, the method comprising: preparing a suspension from primary particles of the hydrophobic active substance, the suspension comprising a solution of the hydrophobic active substance in a solvent having a solubility greater than 10 g/L, a non-solvent having a solubility less than 0.5 g/L for the hydrophobic active substance, and inert formed pieces having a particle size between 0.1-2 mm that do not dissolve in the solvent for the solution of the hydrophobic active substance or the non-solvent for the hydrophobic active substance, wherein a proportion of the inert formed pieces relative to the total volume of the suspension is about 20-80 vol. %, and wherein the primary particles of the hydrophobic active substance are crystalline and in the most stable crystal modification of the hydrophobic active substance; mixing the prepared suspension to cause crystallization of the hydrophobic active substance out of the suspension forming a crystallization mixture; separating the hydrophobic active substance in the form of particles; and drying the product particles, wherein the primary particles and the product particles are crystalline, are in the most stable crystal modification of the hydrophobic active substance, have a crystal surface area of 3-10 m