Patent ID: 6800641
Filing Date: 2004-10-05
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or dialkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; R2 is hydrogen, hydroxy, halo, carboxy, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, or alkyl of one to six carbon atoms; Z is NR3â€”(CH2)nâ€”Y, Y is hydrogen, hydroxy, cycloalkyl of 3 to 15 carbon atoms, or phenyl, phenoxy, naphthyl, naphthyloxy, heteroaryl, or heteroaryloxy, wherein heteroaryl is selected from thienyl, furanyl, pyridinyl, indolyl, chromanyl, coumarinyl, carbostyrilyl, and quinolinyl; R3 is hydrogen or alkyl of 1 to 6 carbon atoms; n is an integer from 0 to 6; R4 is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, &ohgr;-phenylalkyl, &ohgr;-diphenylalkyl, wherein the alkyl chain contains 1 to 4 carbon atoms, indolyl, indazolyl, pyridinyl, pyrimidinyl, quinolinyl, benzoisothiazolyl, or benzisoxazolyl; R5 is hydrogen, hydroxy, cyano or carboxamido; R6 is hydrogen, 1-benzimidazol-2-onyl, benzoisothiazolyl, or benzisoxazolyl, or â€”Qâ€”Ar; Q is C&boxH;O, CHOH, or (CH2)m, m is an integer from 0 to 4; Ar is phenyl or indolyl; or R5 and R6, taken together with the carbon atom to which they are attached form R7 is hydrogen; and R8 is phenyl, indolyl, naphthyl, thienyl, benzoisothiazolyl, benzisoxazolyl; or R7 and R8, taken together with the carbon atoms to which they are attached form a benzene ring; R9 is hydrogen or alkyl of 1 to 6 carbon atoms; and R10, R11 and R12 are, independently hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof; wherein said phenyl, naphthyl, pyridinyl, pyrimidinyl, pyrazinyl, furyl, thienyl, 1-benzimidazol-2-onyl, benzoisothiazolyl, or benzisoxazolyl groups are optionally substituted with substituents selected from hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms.