Patent ID: 6387926
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of the formula I wherein: r, s and t are 0 or 1; l is 0; m is 1; n is 1; Y is selected from the group consisting of CHR12, SO2, SO3, CO2, O, NR13, SO2NR14, CONR15, C(NCN), C(NCN)NR16, NR17CO, NR18SO2, CONR19NR20, SO2NR21 NR22, S(O)(NR23), S(NR24)(NR25), or without Y; Z is selected from the group consisting of S, SO, SO2, SO3, CO, CO2, O, NR13, SO2NR14, CONR15, NR26NR27, ONR28, NR29O, NR30SO2NR31, NR32SO2, NR33C(NCN), NR34C(NCN)NR35, NR36CO, NR37CONR38, NR39CO2, OCONR40, S(O)(NR41), or S(NR42)(NR43); R7, R8 are selected from the group consisting of hydrogen, halo, nitro, cyano and U-R44; U is selected from the group consisting of S, O, NR45, CO, SO, SO2, CO2, NR46CO2, NR47CONR48, NR49SO2, NR50SO2NR51, SO2NR52, NR53CO, CONR54, PO2R55 and PO3R56 or without U; R9, R10, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R45, R46, R47, R48, R49, R50, R51, R52, R53, R54, R55, R56, R57, R58 and R59 are selected from the group consisting of hydrogen, lower alkyl, aryl, heterocyclo, substituted alkyl or aryl; R11 and R44 are selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aralkyl, cycloalkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo; R1, R2, R3 R4, R5 and R6 are selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aralkyl, cycloalkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, cyano, alkoxycarbonyl, carboxy, carbamyl, substituted carbamyl wherein substituents on the nitrogen of the substituted carbamyl are selected hydrogen, alkyl, substituted alkyl, aryl or aralkyl, substituted aryl, heterocyclo, substituted heterocyclo; any two of R1, R2, R3, R4, R5 and R6 can join to form a cycloalkyl group; any two of R1, R2, R3, R4, R5 and R6 together can be oxo, except when the carbon atom bearing the substituent is part of a double bond; R, S and T are selected from the group consisting of CH2, and CH(CH2)pQ wherein Q is NR57R58, OR59, or CN; wherein p is 0, 1 or 2; and A, B, C and D are carbon; its enantiomers, diastereomers, pharmaceutically acceptable salts and solvates thereof; with the provisos that: R11 may be hydrogen except when Z is SO, or when Z is O, NR13 or S and the carbon to which it is attached is part of a double bond or when Y is SO2, CO2, NR18SO2, S(O)(NR23), or S(NR24)(NR25); and R44 may be hydrogen except when U is SO, SO2, NR46CO2 or NR49SO2.