Patent ID: 7582657
Filing Date: 2009-09-01
Classification: A61P,C07D

Abstract:
1. A compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein: n is independently, at each instance, 0, 1 or 2, R or R 1 is a saturated or unsaturated 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, and the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ; R R R or R 4 is an unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, oxo, —R d , —S(═O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —OC 1-6 alkylC(═O)OR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , —C(═O)C 1-6 alkyl, —C(═O)OC 1-6 alkyl, —OC(═O)C 1-6 alkyl, —C(═O)NR d C 1-6 alkyl and —NR d C(═O)C 1-6 alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any nitrogen atoms in the bridge are substituted by H, —C 1-6 alkylOR d , —C 1-6 alkyl, —C 1-6 alkylNR d R d , —C 1-3 alkylC(═O)OR d , —C 1-3 alkylC(═O)NR d R d , —C 1-3 alkylOC(═O)C 1-6 alkyl, —C 1-3 alkylNR d C(═O)C 1-6 alkyl, —C(═O)R f or —C 1-3 alkylR f ; or R 4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, OR d , NR d R d , C 1-6 alkyl and C 1-3 haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; but in no instance is R 4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl; R R R R R R R R R R R R R