Patent ID: 6221876
Filing Date: 2001-04-24
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR10##where:R is hydrogen, COR.sup.1, SO.sub.2 R.sup.2, or a moiety of the formula ##STR11##R.sup.1 is C.sub.1 -C.sub.4 alkyl, aryl, substituted aryl, furanyl, indolyl, thiophenylmethyl, 5-methylisoxazolyl, NHR.sup.4, or CHR.sup.5 OR.sup.6 ;R.sup.2 is 3,5-dimethylisoxazolyl or phenyl where the phenyl group is optionally substituted once with nitro, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkanoyl, carbo(C.sub.1 -C.sub.4 alkoxy), or amino(C.sub.1 -C.sub.4 alkyl);R.sup.3 is phenyl where the phenyl group is optionally substituted once with trifluoromethyl or N-acetylamino;R.sup.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, or phenyl where the phenyl group is optionally substituted once with nitro, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkanoyl, carbo(C.sub.1 -C.sub.4 alkoxy), or amino(C.sub.1 -C.sub.4 alkyl);R.sup.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, or phenyl; andR.sup.6 is phenyl or acetyl; or a pharmaceutical salt or solvate thereof.