Patent ID: 7365064
Filing Date: 2008-04-29
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula (I) its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, or its pharmaceutically acceptable solvates wherein R 1 , R 2 and R 3 , R 4 when attached to the carbon atom, are the same or different and represent hydrogen, halogen, hydroxy, nitro, cyano, formyl or a a group selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyloxy, hydroxyalkyl, amino, acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, carboxylic acid or its derivatives, or sulfonic acid or its derivatives, one or both of R 3 and R 4 represents oxo or thioxo group attached to carbon atom; R 3 and R 4 when attached to a nitrogen atom represent hydrogen, hydroxy, formyl or a group selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aralkyl, heterocyclyl, heteroaryl, heteroaralkyl, acyloxy, hydroxyalkyl, amino, acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, aminoalkyl, aryloxy, aralkoxy, heteroaryloxy, heteroaralkoxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl groups, carboxylic acid derivatives, or sulfonic acid derivatives; X is oxygen; W represents NR 12 , —C(═O)—(CR 10 R 11 ) o NR 12 , or —O-aryl-(CR 10 R 11 ) o NR 12 , where R 12 represents hydrogen or a group selected from alkyl, aryl or aralkyl group; o is an integer of from 0 to 6; R 10 and R 11 are same or different and represent hydrogen or a group selected from alkyl, alkoxy, aryl or aralkyl group; Ar represents a divalent single or fused aromatic or heterocyclic group selected from divalent phenylene, naphthylene, pyrrolyl, pyridyl, quinolinyl, benzofuryl, dihydrobenzofuryl, benzopyranyl, dihydrobenzopyranyl, indolyl, indolinyl, azaindolyl, azaindolinyl, pyrazolyl, benzothiazolyl or benzoxazolyl; R 5 represents hydrogen atom, hydroxy, alkoxy, halogen, alkyl, aralkyl group or forms a bond together with the adjacent group R 6 ; R 6 represents hydrogen, hydroxy, alkoxy, halogen, alkyl group, aralkyl or R 6 forms a bond together with R 5 ; R 7 represents hydrogen or a group selected from alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, heterocyclyl, heteroaryl, or heteroaralkyl R 8 represents hydrogen or a group selected from alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl or heteroaralkyl; Y represents oxygen, sulfur or NR 9 , where R 9 represents hydrogen or a group selected from alkyl, aryl, hydroxyalkyl, aralkyl heterocyclyl, heteroaryl, or heteroaralkyl or NR 9 represents chiral amine, or a chiral amine alcohol derived from a chiral amino acid; and m and n are integers from 0 to 6.