Patent ID: 7790201
Filing Date: 2010-09-07
Classification: A61K

Abstract:
1. A non-coated, sustained release pharmaceutical composition consisting of a plurality of granules, the granules consisting of: (i) about 10% to about 60% by weight of a non-coated complex particulate comprising an ion consisting of a styrene-divinylbenzene sulfonic acid cationic exchange resin and a pharmaceutically active material complexed with the ion exchange resin, the pharmaceutically active material being selected from the group consisting of oxycodone hydrochloride, tramadol hydrochloride, dextromethorphan, hydrocodone bitartrate, chlorpheniramine maleate, codeine, morphine or morphine salt, hydrocodone, phenylpropanolamine, pseudoephedrine, dihydrocodeine, methylephedrine, ephedrin, paraamino salicylic acid, phentermine, pilocarpine, metoclopramide and theophylline; and, (ii) a non-coated, granulated water-insoluble matrix consisting of microcrystalline cellulose, wherein the non-coated, complex particulate is embedded into the non-coated, granulated water-insoluble matrix of microcrystalline cellulose, and further wherein the non-coated, granulated water-insoluble matrix of microcrystalline cellulose sustains release of the pharmaceutically active material from the non-coated, complex particulate.