Patent ID: 9175037
Filing Date: 2015-11-03
Classification: A61K,A61P,C07K

Abstract:
1. A compound represented by formula wherein Y represents a polypeptide consisting of an amino acid sequence set forth in SEQ ID NO.: 1 wherein 1 to 4 amino acids are substituted, the amino acid substitution is selected from: (1) substitution of Tyr at position 1 with Arg, NMeArg, or Pro; (2) substitution of Phe at position 2 with Nal(2); (3) substitution of Leu at position 3 with Gln, Arg, Val, Cha or NMeArg; (4) substitution of Arg at position 5 with Gln or NMeArg; (5) substitution of Pro at position 6 with NMeAla; and (6) substitution of Arg at position 7 with Arg(Me); X represents a methoxypolyethylene glycol; X′ is absent or represents a methoxypolyethylene glycol; La is a divalent or trivalent group represented by formula Lb represents —(CH Lc is a divalent group represented by formula (i): wherein m1 is an integer of 0 to 15, and C wherein m1′ is an integer of 0 to 15, j is an integer of 1 to 3; or a salt thereof,