Patent ID: 8609634
Filing Date: 2013-12-17
Classification: A61K,A61P

Abstract:
1. A method for preparing a preserved hyaluronic acid composition, the method comprising: dissolving/diluting in a first quantity of a first aqueous solvent a cationic preservative that is benzalkonium chloride, to form a first volume of the first solution having a cationic preservative concentration of from about 0.001% to about 0.02%; dissolving hyaluronic acid (HA) or physiologically-acceptable salt thereof separately in a second quantity of a second aqueous solvent to form a second volume of the second solution having an HA concentration of at least 0.001%; and combining the first solution of dissolved cationic preservative with the second solution of dissolved HA or physiologically-acceptable salt thereof to form a third solution of volume equal to the total volume of the first volume and the second volume; wherein the first quantity of the first solvent to the second quantity of the second solvent is between about 1.8:1 and about 2.2:1 by volume; and wherein the third solution has a transmittance between about 93% and about 98% at 440 nm before filtration.