Patent ID: 6534545
Filing Date: 2003-03-18
Classification: A61K,A61Q,C07C,C07D,Y10S

Abstract:
An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: in which:X represents: a divalent radical of formula: â€ƒand Y then represents a divalent radicals of following formula: Z being â€”Oâ€”, â€”Sâ€” or Nâ€”R3 R1 represents â€”CH3, â€”(CH2)pâ€”OR4, â€”(CH2)pâ€”COR5 or â€”S(O)tâ€”R8, p being 0, 1, 2 or 3, t being 0, 1 or 2, R4 represents H, lower alkyl, â€”COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, râ€² and râ€³, which are identical or different, represent H, lower alkyl, â€”COR7, aryl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, or râ€² and râ€³, taken together, form a heterocycle selected from the group consisting of piperidino, morpholino, pyrrolidino and piperazino radical, the latter optionally being substituted in the 4-position by a C1-C6 alkyl radical or a mono- or polyhydroxyalkyl, and the salts of the compounds of formula (I), when R1 represents a carboxylic acid functional group, and the geometrcal and optical isomers of the compounds of formula (I).