Patent ID: 7402605
Filing Date: 2008-07-22
Classification: A61P,C07D

Abstract:
1. An 8-azaprostaglandin derivative compound represented by formula (I-a1-1) (wherein Y ring6 is 5 or 6 membered mono-heterocyclic aryl consisting of hetero atoms selected from 1 to 4 nitrogen, 1 to 2 oxygen, and/or 1 to 2 sulfur atoms which may be partially or fully saturated; R U ring 4 is C3-15 mono-, bi- or tri-carbocyclic aryl which may be partially or fully saturated; ring4 may be substituted by 1 to 5 R; R is (1) C1-10 alkyl, (2) C2-10 alkenyl, (3) C2-10 alkynyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) halogen, (7) hydroxy, (8) nitro, (9) —NR R ring5 is (1) C3-15 mono-, bi- or tri-carbocyclic aryl which may be partially or fully saturated or (2) 3- to 15-membered mono-, bi- or tri-heterocyclic aryl which may be partially or fully saturated and contains a hetero atom(s) selected from 1 to 4 nitrogen, 1 to 2 oxygen and/or 1 to 2 sulfur atom(s); ring5 may be substituted by 1 to 3 sustituent(s) selected from following (1)-(9): (1) C1-10 alkyl, (2) C2-10 alkenyl, (3) C2-10 alkynyl, (4) C1-10 alkoxy, (5) C1-10 alkyl substituted by C1-10 alkoxy, (6) halogen atom, (7) hydroxy, (8) C1-10 alkyl substituted by 1 to 3 halogen atom(s), (9) C1-10 alkyl substituted by C1-10 alkoxy substituted by 1 to 3 halogen atom(s); a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof.