Patent ID: 6280704
Filing Date: 2001-08-28
Classification: A61K,G02B

Abstract:
A system for providing a ultrasound image of at least a part of an object or body comprising:an ultrasound imaging apparatus; anda kit capable of producing a stabilized microbubble preparation wherein said preparation comprises an aqueous medium having dispersed therein a plurality of osmotically stabilized microbubbles, said microbubbles comprising a generally spherical microbubble membrane containing at least one modifier gas and at least one gas osmotic agent, wherein said modifier gas and said gas osmotic agent are present in a molar ratio from about 1:100 to about 1000:1 wherein said ratio is effective to stabilize said microbubble preparation, and wherein said gas osmotic agent is selected from the group consisting of perfluoropentane, perfluorocyclopentane, perfluoromethylcyclopentane, perfluorodimethylcyclobutane, perfluorohexane, perfluorocyclohexane, perfluoroheptane, perfluorocycloheptane, perfluoromethylcyclohexane, perfluorodimethylcyclopentane, perfluorotrimethylcyclobutane, perfluorotriethylamine and combinations thereof.