Patent ID: 6084108
Filing Date: 2000-07-04
Classification: C07D

Abstract:
A process for making a substituted thiophene compound having the formula ##STR9## where: R.sub.1 and R.sub.2 are independently selected from the group consisting of H, alkyl, aryl, substituted alkyl or aryl, and a ring combining R.sub.1 and R.sub.2 ;R.sub.3 is selected from the group consisting of H, alkyl, aryl, and substituted equivalents thereof;Z is CN or CO.sub.2 R.sub.4, wherein R.sub.4 is chosen from the group consisting of alkyl and aryl and the substituted equivalents thereof, H, Na, Li, K, and NH.sub.4.sup.+ ;comprising:(a)(1) reacting a mercaptoketone having the formula ##STR10## where: R.sub.1 and R.sub.2 are defined above with an acrylic compound having the formula ##STR11## where: R.sub.3 is defined aboveA is selected from the group consisting of alkoxy, in the presence of an effective amount of a base as a catalyst;(b) aromatizing by acid treatment; and(c) recovering the substituted thiophene product.