Patent ID: 6262255
Filing Date: 2001-07-17
Classification: A61K,A61L

Abstract:
A non-immunogenic biocompatible macromolecular membrane sheet composition comprising: a non-immunogenic biocompatible macromolecular cellulosic membrane sheet having covalently bound to its surface a chondroitin sulfate through a binding moiety selected from the group consisting of divinyl sulfone and butanediol-diglycidyl ether, whereinthe binding moiety is covalently bound to a carbon or an oxygen of the cellulosic membrane sheet by an ether bond or an ester bond, and is covalently bound to a carbon, an oxygen, or a nitrogen of the chondroitin sulfate by an ether bond or an ester bond; and,the cellulosic membrane sheet is reinforced, and the non-immunogenic biocompatible macromolecular membrane sheet composition has a pore size or permeability of less than about 100,000 daltons.