Patent ID: 6667313
Filing Date: 2003-12-23
Classification: A61P,C07D

Abstract:
A compound having the formula: wherein:R1 is hydrogen; R2 is selected form the group of hydrogen, C1-C6 alkyl and C2-C6 alkenyl, wherein the C1-C6 alkyl and C2-C6 alkenyl groups are optionally substituted with C1-C6 alkyl, arylalkyl, or aryl; R3 and R4 each independently is C1-C6 alkyl; R5 and R6 each independently is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 perhaloalkyl, C2-C6 alkenyl, and C2-C6 alkynyl; or R5 and R6 taken together form a &boxH;O; R7 and R8 each independently is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 perhaloalkyl, C2-C6 alkenyl, and C2-C6 alkynyl; or R7 and R8 taken together form a &boxH;O; R9 is hydrogen; R10 is selected from the group F, Cl, Br, CF3, CF2OR2, CH2OR2, [OR2,] and C1-C6 alkyl; R11 is selected from the group of hydrogen, F, Cl, Br, I, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 perhaloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and aryl, wherein the alkyl, haloalkyl, perhaloalkyl, alkenyl, alkynyl, and aryl, groups are optionally substituted with hydrogen, F, Cl, Br, C1-C4 alkyl, OR2, NR13R14, or SR2; R12 is selected from the group of hydrogen, C(O)R11, SR2, S(O)R13, S(O2)R13, C1-C6 alkyl, C2-C6 alkenyl, aryl and benzyl, wherein the alkyl, alkenyl, aryl, and benzyl groups are optionally substituted with hydrogen, F, Cl, Br, C1-C4 alkyl, OR2, NR13R14, or SR2; X is S(O)R13; R13 is selected from the group of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C1-C6 perhaloalkyl, aryl, and arylalkyl, wherein the alkyl, alkenyl, haloalkyl, perhaloalkyl, aryl, and arylalkyl groups are optionally substituted with hydrogen, F, Cl, Br, C1-C4 alkyl, OR2, NR13R14, or SR2; R14 each independently is selected from the group of hydrogen C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C1-C6 perhaloalkyl, aryl, and arylalkyl, wherein the alkyl, alkenyl, haloalkyl, perhaloalkyl, aryl, and arylalkyl groups are optionally substituted with hydrogen, F, Cl, Br, C1-C4 alkyl, OR2, NR13R14, or SR2; with the proviso that when the dotted line in the ring structure is a double bond, R6 and R7 are absent; or a pharmaceutically acceptable salts thereof.