Patent ID: 6153641
Filing Date: 2000-11-28
Classification: A61P,C07D

Abstract:
A compound of formula (IA) ##STR5## wherein: A.sub.1, A.sub.2, A.sub.3, A.sub.4, B.sub.1, B.sub.2, B.sub.3 and B.sub.4, which may be the same or different, are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, carboxy C.sub.1 -C.sub.4 alkyl, or halogen,n is 0 or 1,R is a 5 or 6 membered aromatic carbocyclic or aromatic heterocyclic ring, the heterocyclic ring containing N or S,R is a substituted by R.sub.1 and up to four of R.sub.2, R.sub.3, R.sub.4, and R.sub.5, wherein;R.sub.1 is aminomethyl, (N-(C.sub.1-4 -alkyl)amino)methyl, (N,N-di(C.sub.1-4 -alkyl)amino)methyl or pyridiniummethyl, andeach of R.sub.3, R.sub.4 and R.sub.5 independently, which may be the same or different, is hydrogen, hydroxy, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl, tri(C.sub.1-4 -alkyl)silyl(C.sub.1-4 -alkoxy)(C.sub.1-4 -alkoxy), or halogen, andR.sub.2 is hydrogen, hydroxy, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl, tri(C.sub.1-4 -alkyl)silyl(C.sub.1-4 -alkoxy)(C.sub.1-4 -alkoxy), halogen orR.sub.2 forms a ring together with the 2-carbon atom on the indole to which the --(CH.sub.2)-- group is attached when R.sub.2 is in a position contigous to the bond connecting R to the --(CH.sub.2).sub.n -- group and n is 1; andX is hydrogen or is deleted when R.sub.2 forms a ring together with the 2-carbon atom on the indole to which the --(CH.sub.2)-- group is attached where R.sub.2 is in a position contigous to the bond connection R to the --(CH.sub.2).sub.n -- group and n is 1;or a pharmaceutically acceptable salt thereof.