Patent ID: 8153781
Filing Date: 2012-04-10
Classification: A61K,A61P

Abstract:
1. A conjugate comprising a dendrimer, at least one ligand covalently linked to the dendrimer, and optionally one or more surface modifying moieties covalently linked to the dendrimer, wherein the ligand is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, with the proviso that when a functionalized congener of an agonist or antagonist of a P2Y receptor is present as a ligand, the conjugate also includes at least one additional ligand which is a functionalized congener of an agonist or antagonist of an adenosine receptor selected from the group consisting of A 1 , A 2A , A 2B , and A 3 adenosine receptors.