Patent ID: 8299296
Filing Date: 2012-10-30
Classification: A61P,C07B,C07C,C07D

Abstract:
1. A spiro compound of the following general formula [Ia]: or a pharmaceutically acceptable salt thereof, wherein: R (1) a hydrogen atom, (2) a C (3) a C (4) a C (5) a C (6) a hydroxy C (7) a C (8) —CONR (9) a phenyl group or (10) a five-membered heteroaryl group which has at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, and which is optionally substituted by a C R (1) a halogen atom, (2) a C (3) a hydroxy group or (4) a C p is 0, 1, 2 or 3; X is a carbon atom or a nitrogen atom; m1 is 0, 1 or 2; m2 is 0 or 1; spiro-ring AB is optionally substituted by 1 to 5 same or different substituent(s) selected from the group consisting of (1) a hydroxy group, (2) a C (3) a C (4) an oxo group; n1 is 0, 1, 2, 3 or 4; n2 is 1, 2, 3 or 4; n3 is 0, 1 or 2 with the proviso that n2+n3 is 2, 3 or 4; and a bond represented by the symbol: means a single bond or a double bond with the proviso that three contiguous carbon atoms do not constitute an allene bond represented by the formula: