Patent ID: 7868180
Filing Date: 2011-01-11
Classification: C07D

Abstract:
1. A process for the preparation of a sartan derivative of formula (I) wherein can be a single bond or a double bond and wherein if and if or a pharmaceutically acceptable salt thereof, comprising the steps of: reacting 2-cyanophenylboronic acid or a derivative thereof, wherein said 2-cyanophenylboronic acid or derivative is selected from (a) a compound represented by formula (III) wherein the R or an alkali metal salt thereof, (b) a compound represented by formula (IV) wherein n is 0 or 1; and A or (c) a compound represented by formula (V) wherein M is an alkali metal or an NR wherein in the presence of a solvent, a transition metal catalyst and an inorganic or organic base to form a substituted biphenyl imidazole compound of formula (II) wherein converting the compound of formula (II) into the corresponding 2-tetrazole derivative to obtain a sartan derivative of formula (I) and, optionally, converting the sartan derivative into one of its pharmaceutically acceptable salts or esters.