Patent ID: 7846891
Filing Date: 2010-12-07
Classification: A61K,A61P

Abstract:
1. A composition comprising: a nanoscale structured material comprising, self-assembling RADA 16-I (SEQ ID NO. 1) peptides provided at a concentration of between 0.1% (1 mg/ml) and 10% (100 mg/ml), inclusive, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible, and wherein the nanoscale structured material provides an environment that is permissive for the repair of neural axons, one or more regeneration promoting factors; and an siRNA, shRNA, or a template for synthesis of an siRNA or shRNA that is targeted to a transcript that encodes the molecule that inhibits regeneration or repair.