Patent ID: 6646124
Filing Date: 2003-11-11
Classification: C07D

Abstract:
A compound of the formula: or a Pharmaceutically acceptable salt thereof wherein:X is (i) hydrogen, halogen, mono- or dialkylamino, alkoxy, (ii) a group of the formula: where G is lower alkylene having 1-6 carbon atoms, or a cyclic group of the formula where n is 0, 1, or 2, and m is an integer of from 1 to 5, with the proviso that the sum of n+m is not less than 1 or greater than 5; and R1 is hydrogen, lower alkyl, or (C3-C7)cycloalkyl, where the alkyl or cycloalkyl is optionally substituted with halogen, lower alkoxy, or mono- or di (C1-C6) alkylamino; (iii) a group of the formula: where C is as defined for ii; and R2 and R3 independently represent hydrogen, lower alkyl having 1-6 carbon atoms, cycloalkyl having 3-7 carbon atoms, â€”SO2R8 where R8 is (C1-C6)alkyl, (C3-C7)cycloalkyl, or optionally substituted phenyl, or R2 and R3 together with the nitrogen atom to which they are attached form a heterocyclic moiety such as imidazolyl, pyrrolidinyl, morpholinyl, piperazinyl, or piperidinyl; (iv) a group of the formula: where R2 is as defined for iii; R4 is hydrogen, lower alkyl having 1-6 carbon atoms, or cycloalkyl having 3-7 carbon atoms, and may be optionally substituted with one or more (C1-C6)alkoxy or mono-or di(C1-C6)alkylamino groups; and G is as defined for ii; (v) a group of the formula: where R2 and G are as defined for iv and ii, respectively, and R5 and R6 independently represent hydrogen, lower alkyl having 1-6 carbon atoms, cycloalkyl having 3-7 carbon atoms, â€”SO2R8 where R8 is (C1-C6)alkyl, (C3-C7)cycloalkyl, or optionally substituted phenyl, or R5 and R6 together with the nitrogen atom to which they are attached form a heterocyclic moiety; (vi) a group of the formula: where G is as defined for ii; or (vii) a group of the formula: where each G is as defined above for ii; and Y is (viii) pyrimidinyl (C1-C6alkyl) or pyridyl (C1-C5) alkyl; or (ix) a group of the formula: where is R18 hydrogen, amino, mono-, or di(C1-C6)alkylamino, or C1-C6 alkyl optionally substituted with R19 where R19 represents: where V and Vâ€² are independently CH or nitrogen; Aâ€³ is C1-C6 alkylene; and R20 is phenyl, pyridyl, or pyrimidinyl, each of which is optionally mono-, di-, or tri-substituted independently with halogen, hydroxy, C1-C6alkoxy, amino, and mono- and di(C1-C6) alkylamino.