Patent ID: 7871615
Filing Date: 2011-01-18
Classification: A61K,A61P,C07K

Abstract:
1. A purified humanized antibody which specifically binds beta amyloid peptide (Aβ), or antigen-binding fragment of said humanized antibody, the humanized antibody or antigen-binding fragment comprising a humanized light chain comprising three complementarity determining regions (CDR1, CDR2 and CDR3) from the monoclonal antibody 12A11 light chain variable region sequence set forth as SEQ ID NO:2, and wherein L2 is occupied by V, L4 is occupied by M, L36 is occupied by Y, L38 is occupied by Q, L40 is occupied by P, L44 is occupied by P, L46 is occupied by L, L47 is occupied by L, L48 is occupied by I, L49 is occupied by Y, L64 is occupied by G, L66 is occupied by G, L68 is occupied by G, L69 is occupied by T, L71 is occupied by F, L87 is occupied by Y, and L98 is occupied by F (Kabat numbering convention) and a humanized heavy chain comprising three complementarity determining regions (CDR1, CDR2 and CDR3) from the monoclonal antibody 12A11 heavy chain variable region sequence and wherein at least three variable region framework residues and amino acids occupying them are selected from the group consisting of H24 occupied by F, H28 occupied by S, H29 occupied by L, H37 occupied by I, H48 occupied by L, H67 occupied by L, H71 occupied by K, H73 occupied by T, and H78 occupied by V (Kabat numbering convention).