Patent ID: 6441053
Filing Date: 2002-08-27
Classification: A61K,C12N,C12Q

Abstract:
A method of treating a GSK-3 related disorder other than Alzheimer's disease in an animal comprising administering to said animal a GSK-3 inhibitor suspended in a pharmaceutically acceptable carrier, wherein said GSK-3 inhibitor is not lithium and is identified by:(a) providing a mixture comprising GSK-3, a source of phosphate, a GSK-3 substrate, and a GSK-3 assay buffer; (b) incubating said mixture in the presence or absence of a test compound; (c) measuring the level of phosphorylation of said GSK-3 substrate; and (d) determining whether the level of phosphorylation of said GSK-3 substrate is lower in the presence of said test compound than in the absence of said test compound, and further wherein the GSK-3 related disorder is selected from the group consisting of bipolar disorder, mania, and leukopenia.