Patent ID: 8367402
Filing Date: 2013-02-05
Classification: A61K,C12N

Abstract:
1. A method of remodeling a dendrite, said method comprising: transfecting a dendrite with an RNA comprising at least one intron, wherein said dendrite comprises at least one component of a spliceosome and further wherein said at least one component of a spliceosome is capable of splicing an RNA; wherein said RNA comprising at least one intron is spliced by said at least one component of a spliceosome; wherein the at least one component of a spliceosome is selected from the group consisting of Y14, Magoh, RNPS1, SC-35, SF2, U2AF65, Smith antigen, pan-SR antigen, U1 snRNP, U2 snRNP, U4 snRNP, U5 snRNP, and U6 snRNP; and wherein said spliced RNA is translated in said dendrite; and wherein said dendrite is thereby remodeled as a consequence of said translation.