Patent ID: 7737137
Filing Date: 2010-06-15
Classification: A61P,C07D

Abstract:
1. A method inhibiting 11-β-HSD-1 enzyme comprising administering to the mammal an effective amount of a selective inhibitor of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme activity, wherein the inhibitor is a compound of formula (I) wherein n is 1; R each of which is independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, —CN, —NO 2 , —OR b , —SR b , —S(O)R Z , —S(O) 2 R Z , —NR a R b , —C(O)R b , —C(O)OR b , —C(O)NR a R b , —S(O) 2 NR a R b , —C(═NOH)NH 2 , —C(═NH)NH 2 , R c , and —(CR d R e ) m —CN; R R R R R R R m is 1; or a pharmaceutically acceptable salt, or a combination thereof.