Patent ID: 6417190
Filing Date: 2002-07-09
Classification: A61K,Y10S

Abstract:
A method of treating a disease in a warm-blooded animal, said disease being treatable by inhibiting the production of type IV phosphodiesterase in said animal, which comprises administering to said animal a type IV phosphodiesterase production-inhibiting amount of a tricyclic, nitrogen heterocycle of formula I whereinR1 is C1-C5-alkyl, C5-C6-cycloalkyl, phenyl, benzyl or a 5- or 6-membered, saturated or unsaturated heterocyclic ring which may contain one or two heteroatoms, selected from the group consisting of oxygen and nitrogen; R2 is C1-C5-alkyl or C2-C4-alkenyl; R3 is C1-C5-alkyl, which may optionally be substituted by C1-C4-alkoxy, C5-C6 -cycloalkyl, phenoxy or by a 5- or 6-membered, saturated or unsaturated heterocyclic ring which may contain one or two heteroatoms, selected from the group consisting of oxygen and nitrogen, C5-C6-cycloalkyl or phenyl or benzyl optionally substituted by C1-C4-alkoxy, in the form of racemate, an enantiomer, a diastereomer or a mixture thereof, or in the form of a tautomer or a pharmacologically acceptable addition salt thereof.