Patent ID: 7947692
Filing Date: 2011-05-24
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein X is N, R R R R or R wherein R 3 and R 4 are both CH 2 or one is CH 2 and the other is a methylene mono-substituted with lower alkyl, Ya is a saturated or partially unsaturated alkyl segment of 2 to 3 ring carbons which is substituted with an aromatic substituent selected from the group consisting of aryl, aralkyl, aralkyloxy, aroyl, aryloxy, arylsulfonyl, aralkylamino, aryloxyalkyl, aryloxyalkylamino and aroylamino, and Ya may additionally have 0, 1 or 2 non-aromatic substituents selected from hydroxy, amino, lower alkylamino, lower alkanoylamino, oxo, cyano, carboxy, hydroxyalkylamino, carbamoyl and lower alkylcarbamoyl, or R wherein R 3 and R 4 are both CH 2 or one is CH 2 and the other is a methylene mono-substituted with lower alkyl, Yh is a saturated heteroalkyl segment of 2 to 3 ring atoms one of which is a heteroatom, and Yh is substituted with one aromatic group which in the case of a carbon ring atom is selected from the group consisting of aryl, aralkyl, aroyl, aryloxy, arylsulfonyl, aralkylamino, aryloxyalkyl, aryloxyalkylamino and aroylamino or, in the case of nitrogen, is selected from the group consisting of aryl, aralkyl, aroyl, arylhydroxymethylalkyl, arylcarboxymethylalkyl, arylalkoxymethylalkyl, arylsulfonyl, aryloxyalkyl, arylaminoalkyl and aroylaminoalkyl, or R or R or R or the pharmaceutically acceptable salts or esters thereof.