Patent ID: 6495165
Filing Date: 2002-12-17
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition comprising particulate eplerenone and one or more pharmaceutically acceptable carrier materials; wherein said composition, upon oral administration in an eplerenone dosage amount of about 100 mg to a fasted adult human subject, exhibits an eplerenone pharmacokinetic profile having at least one of (a) Cmax not less than about 1500 ng/ml; (b) Tmax not greater than about 1.8 hours; (c) AUC0-96 not less than about 7900 (ng/ml)hr and (d) plasma concentration one hour after administration not less than about 1225 ng/ml; said dosage amount being administered in one to a plurality of dosage unit forms.