Patent ID: 8697664
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule encoding both a variable light chain and a variable heavy chain of an antibody that specifically binds Platelet Derived Growth Factor Receptor alpha, wherein the antibody comprises: (a) a variable heavy (VH) chain comprising the complementarity determining region (CDR) 1, CDR2, and CDR3 of SEQ ID NO:2 and a variable light (VL) chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:4; or (b) a VH chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:6 and a VL chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:22; or (c) a VH chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:6 and a VL chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:8; or (d) a VH chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:10 and a VL chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:12; or (e) a VH chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:18 and a VL chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:20; or (f) a VH chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:14 and a VL chain comprising the CDR1, CDR2, and CDR3 of SEQ ID NO:16.