Patent ID: 8114844
Filing Date: 2012-02-14
Classification: C07D,C07K

Abstract:
1. A peptidomimetic of the formula or a pharmaceutically acceptable salt thereof, wherein: T Xaa wherein the solid lines indicate a bond; R and R′ are independently H, a linear or branched C Xaa Xaa Xaa Xaa wherein the solid lines indicate a bond; at least one of R and R′ is (CH 2 ) y —R″ and if one, the remaining of R and R′ is H, where R″ is: —NH —NH—C(═NH)—NH —NH—(CH —NH—C(═O)—NH —C(═O)—NH —C(═O)—NH—CH —C(═O)—NH—(CH —NH—C(═NH)—NH-Me, —NH—C(═NH)—NH-Et, —NH—C(═NH)—NH-Pr, —NH—C(═NH)—NH-Pr-i, —NH—C(═O)—CH —NH—C(═O)—CH —NH—C(═O)—CH—(CH —NH—C(═O)—O—CH —NH—C(═O)—O—CH —NH—C(═O)—O—C—(CH —NH—C(═O)—NH—CH —NH—C(═N—C(═O)—O—C—(CH —N(C(═O)—O—C—(CH x is 1 or 2; Y is CH 2 or C═O; W is CH 2 , NH or NR′″; Z is H or CH 3 ; R′″ is an acyl, a C 1 to C 17 linear or branched alkyl chain, a C 2 to C 19 linear or branched alkyl acyl chain, a C 1 to C 17 linear or branched omega amino aliphatic, or a C 1 to C 17 linear or branched omega amino aliphatic acyl; n is 0, 1 or 2; m is 0 to 17; y is 1 to 5; and the carbon atoms marked with an asterisk can have any stereochemical configuration; Xaa Xaa T on the proviso that at least one of Xaa