Patent ID: 6093420
Filing Date: 2000-07-25
Classification: A61K,A61P,Y10S

Abstract:
A sustained release dosage form, comprising from about 500 mg to about 1000 mg of an insoluble NSAID and an effective amount of a sustained release carrier comprising xanthan gum, locust bean gum and a pharmaceutically acceptable inert diluent, wherein the total weight of said dosage form is from about 110 percent to about 140 percent by weight of said insoluble NSAID, said xanthan gum and said locust bean gum comprising from about 7 to about 40 percent by weight of the dosage form, said locust bean gum comprising from about 50% to about 95% of the sustained release carrier, said dosage form providing a dissolution of said NSAID in-vitro when measured by the USP Type II (Paddle) Method, of from about 6 percent by weight of said NSAID released after about 2 hours and a t.sub.5 at about 12 to about 16 hours.