Patent ID: 8741623
Filing Date: 2014-06-03
Classification: C12N,C12P

Abstract:
1. A recombinant microorganism of the genus Corynebacterium which has a deregulated lysine decarboxylase gene and a deregulated diamine acetyltransferase gene and at least one deregulated gene (i) selected from the group consisting of up-regulated aspartokinase, up-regulated aspartatesemialdehyde dehydrogenase, up-regulated dihydrodipicolinate synthase, up-regulated dihydrodipicolinate reductase, up-regulated tetrahydrodipicolinate succinylase, up-regulated succinyl-amino-ketopimelate transaminase, up-regulated succinyl-diamino-pimelate desuccinylase, up-regulated diaminopimelate epimerase, up-regulated diaminopimelate dehydrogenase, up-regulated arginyl-tRNA synthetase, up-regulated diaminopimelate decarboxylase, up-regulated pyruvate carboxylase, up-regulated phosphoenolpyruvate carboxylase, up-regulated glucose-6-phosphate dehydrogenase, up-regulated transketolase, up-regulated transaldolase, up-regulated 6-phosphogluconolactonase, up-regulated fructose 1,6-biphosphatase, down-regulated homoserine dehydrogenase, down-regulated phophoenolpyruvate carboxykinase, down-regulated succinyl-CoA synthetase, and down-regulated methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as the at least one deregulated gene (i), at least a second gene (i) other than aspartokinase has to be deregulated, wherein the deregulated diamine acetyltransferase gene is from Corynebacterium.