Patent ID: 8071084
Filing Date: 2011-12-06
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method of protecting a susceptible host against an infection of Shigella sonnei ( S. sonnei ) comprising administering to said host an amount of an immunoprotective composition sufficient to invoke an immunoprotective response in the host, wherein the composition comprises an attenuated bacteria expressing an antigen comprising the wherein said attenuated bacteria comprises an expression cassette comprising the genes wbgT, wbgU, wzx, wzy, wbgV, wbgW, wbgX, wbgY, and wbgZ isolated from the wherein the expression cassette does not include at least one of the following genes: IS1, wzz, IS630, aqpZ, IS629, IS91, and IS911.