Patent ID: 7045504
Filing Date: 2006-05-16
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method of antagonizing a urokinase receptor (uPAR) which comprises administering to a subject in need thereof an effective amount of a compound of the formula (I) wherein X 21 –X 30 are monomeric building blocks, preferably aminocarboxylic acid residues and are derived from a structure in which X 21 =D-Cys, X 22 =Asn, X 23 =Lys, X 24 =Tyr, X 25 =Phe, X 26 =Ser, X 27 =Asn, X 28 =Ile, X 29 =Cys and X 30 =Trp, Y is a spacer and m is 0 or 1, and the monomeric building blocks are linked via —CONR 1 or —NR 1 CO bonds, in which R 1 in each case independently is hydrogen, methyl or ethyl, and pharmaceutically acceptable salts and derivatives thereof, with the proviso that at least one of the amino acid residues X 21 –X 30 is replaced by one of the amino acid residues listed below: X X X X X X X X X