Patent ID: 8633193
Filing Date: 2014-01-21
Classification: A61P,C07D

Abstract:
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: E is a single bond, O, S(O) R m is 0, 1, or 2; Ar is chosen from: phenyl which is mono-, di-, or tri-substituted, 1-naphthyl and 2-naphthyl, each of which is optionally mono-, di-, or tri-substituted, and optionally mono-, di-, or tri-substituted heteroaryl, said heteroaryl having from 1 to 3 rings, 5 to 7 ring members in each ring and, in at least one of said rings, from 1 to about 3 heteroatoms selected from the group consisting of N, O, and S; the group: represents an aromatic 5-membered ring system containing exactly one heteroatom, wherein: Z Z R Z R R R R X is independently selected at each occurrence from the group consisting of —CH Y and Z are independently selected at each occurrence from: 3- to 7-membered carbocyclic or heterocyclic groups which are saturated, unsaturated, or aromatic, which may be further substituted with one or more substituents independently selected from halogen, oxo, hydroxy, amino, cyano, C n is independently selected at each occurrence from 0, 1, and 2.