Patent ID: 8143391
Filing Date: 2012-03-27
Classification: A61K,A61P,C08B,C08J,C08L

Abstract:
1. A process for producing a water-soluble modified hyaluronic acid, which comprises converting a carboxy group contained in the glucuronic acid portion of hyaluronic acid or a salt thereof to a substituted amide group in a solvent consisting of dimethyl sulfoxide, using a condensing agent represented by the following formula (II): wherein each of R wherein the substituted amide group is formed by allowing hyaluronic acid or a salt thereof to react with one or more compounds selected from the group consisting of the following formulas: wherein each of m and p independently represents an integer selected from 2 to 10; t represents an integer selected from 1 to 200; R wherein the modification ratio is from 60 mole % to 100 mole %; and wherein the modification ratio is defined as a ratio of total number of substituted amide groups relative to the total number of the carboxy groups originally contained in the hyaluronic acid or the salt thereof.