Patent ID: 8598232
Filing Date: 2013-12-03
Classification: A61P,C07C

Abstract:
1. A process for producing non-genotoxic Diacerein, starting from raw Diacerein or raw Rhein, comprising the following successive steps: a. transforming raw Diacerein or raw Rhein into a water-soluble salt thereof; then b. dissolving said salt in water; c. adsorbing Diacerein or Rhein on a hydrophobic resin, by percolation of the aqueous solution obtained after step b. through a column filled with hydrophobic resin; d. after step c., desorbing the impurities using an organic solution, recovering the organic fractions which contain the impurities; e. after step d., desorbing Diacerein or Rhein using an hydro alcoholic solution, recovering the hydro alcoholic fractions which contain Diacerein or Rhein salt; f. acidifying the collected hydro alcoholic fractions recovered after step e.; g. recovering and drying non-genotoxic Diacerein.