Patent ID: 6979695
Filing Date: 2005-12-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula: wherein X is selected from the group consisting of C—H, C—F, C—Cl, C—Br, C—I, C—R′, C—NR′R″, C—CF 3 , C—CN, C—NO 2 , C—C 2 R′, C—, C—SCH 3 , C—N 3 , C—SO 2 CH 3 , C—OR′, C—SR′, C—C(═O)NR′R″, C—NR′C(═O)R′, C—C(═O)R′, C—C(═O)OR′, C(CH 2 ) q OR′, C—OC(═O)R′, COC(═O)NR′R″ and C—NR′C(═O)OR′, X′ is N or NO, q is an integer from 1 to 6; each A, A″ and A′″ individually is a substituent selected from the group consisting of H, F, Cl, Br, I, R′, —NR′R″, —CF m and n are integers such that the sum of m and n is an integer from 1 to 8 and n is at least 1; E each Z′ and Z″ individually is hydrogen, lower alkyl, —C(═O)R′, —C(═O)OR′, —C(═O)NR′R″, —C(═S)R′, —C(═S)OR′, —C(═S)NR′R″, —C(═NR′)R′, —C(═NR′)OR′, or —C(═NR′)NR′R″; and R′ and R″ are, individually, hydrogen, C wherein the aromatic group-containing species is pyridyl, quinolinyl, pyrimidinyl, phenyl, or benzyl and the substituents are as defined above with respect to A, A′, and A″ or pharmaceutically acceptable salt thereof.