Patent ID: 6790858
Filing Date: 2004-09-14
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I): whereinR1 (a) is an acyl group â€”COâ€”R11 or CN, wherein R11 is a saturated, unsaturated, cyclic and/or (hetero)aromatic organic radical, a straight or branched alkyl chain with 1-10 C atoms or a phenyl, furan or thiophene group that is optionally substituted by an alkyl group or a halogen atom, â€ƒb) is a carboxylic acid ester group â€”COâ€”OR12 or a carboxylic acid amide group â€”COâ€”NR12R13 or a group â€”SOxâ€”R12 with X=0, 1 or 2 or â€”SO2â€”NR12R13, wherein R12 is a saturated, unsaturated, cyclic and/or (hetero)aromatic organic radical, a straight or branched alkyl chain with 1-10 C atoms, an aralkyl group with 7-20 C atoms, wherein the aryl radical optionally can be substituted by alkyl groups or halogen atoms or is a phenyl radical that is optionally substituted by alkyl groups or halogen atoms, and R13 can be a hydrogen atom or a straight or branched alkyl chain with 1-10 C atoms, or â€ƒ(c) is the group â€”Aâ€”NR14-COâ€”NR15R16, in which A is an alkylene group with 1-4 C atoms, that is optionally substituted by a C1-C6 alkyl group, a carbonyl group, an oxygen atom or the group â€”SOxâ€” with X=0, or 2; R14 and R15, in each case independently are a hydrogen atom or a straight or branched alkyl chain with 1-10 C atoms, and R16 is a straight or branched alkyl chain with 1-10 C atoms, a cycloalkyl group with 3-10 C atoms, a cycloalkylalkyl group with 7-20 C atoms, an aralkyl group with 7-20 C atoms, wherein the aryl radical optionally can be substituted by alkyl groups or halogen atoms, a phenyl group that is optionally substituted by alkyl groups or halogen atoms or a heterocyclic ring that is optionally substituted by alkyl groups or halogen atoms, R2 is group â€”CH(R21)R22, whereby R21 is a hydrogen atom, a C1-C10-alkyl group or an optionally substituted phenyl ring and R22 is an optionally substituted phenyl ring or naphthyl ring, or a group â€”CH2CH(R23)R24, with R23 and R24 in the meaning of an optionally substituted phenyl ring, R3 and R4 in each case independently are a hydrogen atom or an alkyl group with 1-10 atoms and R3 also can be a halogen atom, R5 is a group that is linked via radical Z, â€ƒin which G is â€”C&boxH;Câ€”, â€”C&boxH;Nâ€”, â€”N&boxH;Câ€”, an oxygen or sulfur atom, Z is a direct bond, an oxygen atom or a sulfur atom, the group CHâ€”R52 or â€”CHR52-CHâ€”R53-, whereby R52 and R53, independently of one another, have the meaning of a hydrogen atom or an alkyl group and n means numbers 1 and 2, a â€”Câ‰¡Câ€” triple bond or an E- or Z-configured group â€”CR52=CR53- or C&boxH;CR52R53, whereby R52 and R53, independently of one another, have the meaning of a hydrogen atom or an alkyl group, L is a CH2 group or an NH group, Q is a carbonyl group or â€”SOx group, with X=0, 1 or 2, and R51 is an amino group that is optionally substituted by an alkyl group, or a straight or branched alkyl group that is optionally substituted by halogen atoms, hydroxyl or alkoxy groups, or a cycloalkyl group with 3-7 ring members that is optionally substituted by halogen atoms, hydroxyl or alkoxy groups, R6 is the group CH2â€”N(R61)R62, whereby R61, in each case independently, is a hydrogen atom or an alkyl group, and R62 is an alkyl group or an optionally substituted aralkyl group or a heteroarylalkyl group with 7-20 C atoms, and â€ƒâ€”W&boxH;X&boxH;Yâ€”â€” is the group â€ƒin any orientation; and a steroisomer of any of the above-mentioned structures, and a salt thereof with a physiologically compatible acid or base.