Patent ID: 6025444
Filing Date: 2000-02-15
Classification: C07C,C07K,C08B,C08L

Abstract:
A cinnamic acid-polysaccharide derivative represented by any of the formulas (13)-(15):R.sup.1 --A--P.sup.1 ( 13)R.sup.1 --B--P.sup.2 ( 14)R.sup.2 --C--P.sup.1 ( 15)wherein R.sup.1 represents a group of the formula (4): ##STR21## wherein R.sup.3 and R.sup.4 independently represent a hydrogen atom, a nitro group, an amino group hydroxyl group or a C.sub.1-4 alkoxy group;R.sup.2 represents a group of the formula (5): ##STR22## wherein R.sup.3 and R.sup.4 are as defined above; R.sup.5 represents a lower alkyl group;--A represents an amino- and hydroxy-containing compound residue represented by any of the formulas (6')-(9'):--O--(CH.sub.2).sub.n --NH (6')wherein n represents a whole number of 3-18,--(O--CH.sub.2 CH.sub.2).sub.m --NH (7')wherein m represents a whole number of 2-10,--O--CHR.sup.6 CH(COOR.sup.7)--NH (8')wherein R.sup.6 represents a hydrogen atom or a lower alkyl group;R.sup.7 represents a lower alkyl group,--O--(CH.sub.2).sub.l --NHCO--CHR.sup.8 --NH (9')wherein l represents a whole number of 2-18; R.sup.8 represents the side chain of an .alpha.-amino acid residue;--B represents an amino acid residue of the formula (10'):--NH--(CH.sub.2).sub.k --CO (10')wherein k represents a whole number of 1-18;--C represents an amino acid residue of the formula (11') or (12');--CO--(CH.sub.2).sub.k --NH (11')wherein k is as defined above,--(COCHR.sup.8 NH).sub.i ( 12')wherein i represents a whole number of 1-6; R.sup.8 is as defined above;P.sup.1 represents a carboxy-containing polysaccharide residue; P.sup.2 represents a hydroxy-containing polysaccharide residue; andthe A--P.sup.1 linkage is the amide bond between the terminal amino residue of the formula (6'), (7'), (8') or (9') and the carboxyl residue of P.sup.1 ; the B--P.sup.2 linkage is the ester bond formed between the terminal carboxyl residue of the formula (10') and the hydroxyl residue of P.sup.2 ; and the C--P.sup.1 linkage is the amide bond between the terminal amino residue of the formula (11') or (12') and the carboxyl residue of P.sup.1 ;with the provisos that the polysaccharide is a hyaluronic acid and the photodimerizable-crosslinkable group is introduced into the cinnamic acid-polysaccharide derivative at a degree of substitution of 0.05-5.0% to a repeating constituent saccharide unit of the hyaluronic acid.