Patent ID: 6683181
Filing Date: 2004-01-27
Classification: A61P,C07D,Y02P

Abstract:
A method for making an intermediate of formula C2-12alkynyl-NRxRx comprising t e steps of:(a) mixing polystyrene-Ts-Cl resin with a C2-12alkynol, an (b) reacting the product of step (a) with a compound of formula HNRxRx, wherein each Rx is independently H, C1-7alkyl, or each Rx taken together with the nitrogen form a het; wherein het is a four-(4), five-(5), six-(6), or seven-(7) membered saturated or unsaturated heterocyclic ring optionally having 1 or 2, additional heteroatoms selected from the group consisting of O, SOm, and NX; wherein X is H, C1-4alkyl or absent, wherein het is optionally substituted with one or more halo, C1-4alkyl, CF3, oxo or oxime; wherein m is 0, 1, or 2.