Patent ID: 8268855
Filing Date: 2012-09-18
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof wherein R 1 is C 1-3 alkyl; R 2 is hydrogen; R 5 is —NR 3 R 4 ; R 3 and R 4 are independently selected from (a) hydrogen, or (b) alkyl, which may be optionally independently substituted as valence allows with one or more Z R 6 is pyridyl, which is substituted with Z R 7 is hydrogen; R 8 is (a) hydrogen, (b) alkyl, or alkenyl, either of which may be optionally substituted with one or both of hydroxyalkyl and hydroxy; Z 1d is an optional substituent at each occurrence independently selected from —W 1 —V 1 , where W 1 is independently selected from (1) a bond, and (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl, where heterocyclo alone or as part of another group is piperazinyl, morpholinyl, pyrrolo, or pyrrolidinyl, and where heteroaryl alone or as part of another group is imidazolyl, any of which W where V 1 is independently selected from (1) H, (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl, where heterocyclo alone or as part of another group is piperazinyl, morpholinyl, pyrrolo or pyrrolidinyl, and where heteroaryl alone or as part of another group is imidazolyl, any of which V (3) —U (4) —U (5) —U (6) —U (7) —U (8) —U (9) —U (10) —U (11) —U (12) —U (13) —U (14) —U (15) —U (16) —U (17) —U (18) —U (19) —U V 1a is independently hydrogen, alkyl, —CN, —C(O)Y 1 , or —C(O)NY 2 Y 3 ; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl, any of which may be optionally independently substituted as valence allows with one or more Z the term “heteroaryl”, alone or as part of another group, is thiadiazolyl, pyridyl, pyrazinyl, or imidazolyl; and the term “heterocyclo”, alone or as part of another group, is pyrrolo, tetrahydrofuranyl, dioxolanyl, piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl, or oxopyrrolidinyl; Z 4 , Z 5 , and Z 6 are optional substituents at each occurrence independently selected from (1) H, (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo which is tetrahydrofuranyl, piperidinyl, or pyrrolidinyl, or heteroaryl which is furanyl or pyridinyl, (3) —U (4) —U (5) —U (6) —U (7) —U (8) —U (9) —U (10) —U (11) —U (12) —U (13) —U (14) —U (15) —U (16) —U (17) —U Y 1a , Y 2a , Y 3a , Y 4a and Y 5a are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl; the term “heteroaryl”, alone or as part of another group, is thiadiazolyl, pyridyl, pyrazinyl, or imidazolyl; and the term “heterocyclo”, alone or as part of another group, is pyrrolo, tetrahydrofuranyl, dioxolanyl, piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl, or oxopyrrolidinyl; U 1 is independently (1) a single bond, or (2) alkylene.