Patent ID: 6365712
Filing Date: 2002-04-02
Classification: A61K,C07K

Abstract:
An isolated soluble CD97 &agr; subunit, wherein said soluble &agr; subunit is selected from the group consisting of &agr;1, &agr;2, and &agr;3, wherein:contact of endothelial cells with said soluble &agr; subunit increases adherence of the endothelial cells; &agr;3 has a molecular weight of about 45 kDa in non-glycosylated form, has an EGF-like repeat selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:5, and is immunologically cross-reactive to an antibody that is specifically reactive to the protein of SEQ ID NO:6; &agr;2 has a molecular weight of about 50 kDa in non-glycosylated form, has an EGF-like repeat selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:5, and is immunologically cross-reactive to an antibody that is specifically reactive to the protein of SEQ ID NO:6; and, &agr;1 has a molecular weight of about 55 kDa in non-glycosylated form, has an EGF-like repeat selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:5, and is immunologically cross-reactive to an antibody that is specifically reactive to the protein of SEQ ID NO:6.