Patent ID: 9204648
Filing Date: 2015-12-08
Classification: A01N,A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula IA wherein A B is O or CH R R each R each R each R n is 0, 1 or 2; comprising preparing a compound of formula IV by either a. reacting a compound of formula II with a source of cyanide in the presence of water to give a compound of formula III b. reducing the compound of formula III with a suitable reducing agent to give a compound of formula IV c-i. reacting the compound of formula IV with a compound of formula V wherein R is OH, C A) reacting a compound of formula VII with CH B) reducing the compound of formula XI with a suitable reducing agent to give a compound of formula IV; or 1) homologating a compound of formula VII to give an ester of formula XII wherein R is C 2) reducing the compound of formula XII using a suitable reducing agent to give a compound of formula XIII 3) treating the compound of formula XIII with hydrazoic acid to give a compound of formula IV; and c-i. reacting the compound of formula IV with a compound of formula V wherein R is OH, C c-ii reacting the compound of formula IV with a compound of formula VI wherein X with carbon monoxide in the presence of a suitable catalyst to give a compound of formula IA; and wherein the method optionally comprises oxidizing the sulfur atom of the thietane moiety.