Patent ID: 6313127
Filing Date: 2001-11-06
Classification: A61P,C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof, ##STR120##whereinG.sup.1 is CH;G.sup.2 is CH;n is 1 or 2;R is hydrogen, halogeno, trifluoromethyl, trifluoromethoxy, cyano, amino, hydroxy, nitro, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di(1-4C)alkylamino or phenyl(1-4C)alkyl;A is methylene or ethylene; B is ethylene; and wherein A and B may independently optionally bear a substituent selected from (1-6C)alkyl, (1-6C)alkoxy, phenyl(1-4C)alkyl, halogeno and (1-6C)alkoxycarbonyl;T is N;X.sup.1 is selected from SO.sub.2, SO, CO and CR.sup.3 R.sup.4 O; wherein R.sup.3 and R.sup.4 are independently selected from hydrogen and (1-4C)alkyl;Y.sup.1 represents CR.sup.6 R.sup.7, wherein R.sup.6 and R.sup.7 are independently selected from hydrogen and (1-4C)alkyl;Ar.sup.1 is a phenylene, naphthylene, a 5- or 6-membered monocyclic heteroaryl ring containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur, or a 9- or 10-membered bicyclic heteroaryl ring containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur;Q is a group of formula L.sup.1 X.sup.2 L.sup.2 Z in which L.sup.1 is a bond, (1-4C)alkylene or (2-4C)alkenylene, L.sup.2 is a bond or (1-4C)alkylene, X.sup.2 is a bond, O, S, SO, SO.sub.2, CR.sup.8 R.sup.9, CO, OSO.sub.2, OCR.sup.8 R.sup.9, OCO, SO.sub.2 O, CR.sup.8 R.sup.9 O, COO, NR.sup.10 SO.sub.2, SO.sub.2 NR.sup.11, NR.sup.12 CO, CONR.sup.12, NR.sup.13 CONR.sup.14 and NR.sup.14 in which R.sup.8 and R.sup.9 are independently selected from hydrogen, hydroxy and (1-4C)alkyl; and R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 are independently selected from hydrogen and (1-4C)alkyl;Z is hydrogen, (1-4C)alkyl, phenyl, naphthyl, phenyl(2-4C)alkenyl, phenyl(2-4C)alkynyl or a heterocyclic moiety containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur;and wherein the phenyl, naphthyl or heteroaryl moiety in Ar.sup.1 and the alkyl, phenyl, naphthyl, or heterocyclic moiety in Z may optionally bear one or more substituents selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, hydroxy(1-6C)alkyl, (1-6C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkyl, (1-4C)alkylenedioxy, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, N-(1-6C)alkylcarbamoyl, di-N[(1-6C)alkyl]carbamoyl, (1-6C)alkanoylamino, (1-6C)alkoxycarbonyl, (1-6C)alkylthio, (1-6C)alkylsulphinyl, (1-6C)alkylsulphonyl, halogeno(1-6C)alkyl, halogeno(1-6C)alkoxy, (1-6C)alkanoyl, tetrazoyl, phenyl, phenoxy, phenylsulphonylpiperidinocarbonyl, morpholinocarbonyl, hydroxy(1-6C)alkyl and amino(1-6C)alkyl; wherein any phenyl containing substituents may optionally bear one or more substituents selected from halogeno, trifluoromethyl, trifluoromethoxy, cyano, amino, hydroxy, nitro, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino and di(1-4C)alkylamino;provided that the compound is not N-[4-[4-(4-pyridyl)piperazin-1-ylcarbonyl]phenyl]-(E)-4-chlorostyrenesulph onamide or N-[4-[4-(4-pyridyl)piperazin-1-ylcarbonyl]phenyl]-4'-bromo-4-biphenylesulp honamide;and pharmaceutically acceptable salts thereof.