Patent ID: 6348588
Filing Date: 2002-02-19
Classification: C07D,C07H

Abstract:
A method of specifically cleaving a nucleic acid bulge, the method comprising contacting the nucleic acid bulge with a metal complex of the following formula: whereineach of R1, R2, R3, R4, R5, R6, R7, and R8, independently, is hydrogen, alkyl, alkoxy, hydroxyl, hydroxylalkyl, halo, haloalkyl, amino, aminoalkyl, alkylcarbonylamino, alkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkylcarbonyloxy, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; each of R2 and R3, and R6 and R7, independently, optionally joining together to form a cyclic moiety fused with the two pyridyl rings to which R2 and R3, or R6 and R7 are bonded; the cyclic moiety, if present, optionally being substituted with alkyl, alkoxy, hydroxyl, hydroxylalkyl, halo, haloalkyl, amino, aminoalkyl, alkylcarbonylamino, alkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkylcarbonyloxy, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; each of L1 and L2, independently, is â€”Oâ€”, â€”Sâ€”, or â€”N(Rc)â€”; wherein Rc is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; M is a Fe, Co, Ni, Ru, Rh, Mn, Os, Ag, Cr, Zn, Cd, Hg, Re, Ir, Pt, or Pd ion; and each of X1 and X2, independently, is a labile ligand; or a salt thereof.