Patent ID: 6642261
Filing Date: 2003-11-04
Classification: A61K

Abstract:
A pharmaceutical composition comprising a pharmaceutically inert carrier and a pharmaceutically effective amount of a compound of formula I: wherein R1 is selected from the group consisting of:3-pyridyl and 4-pyridyl; R2 is selected from the group consisting of hydrogen, alkyl, phenyl, alkylalkoxy, alkylthioalkoxy; and R3 is selected from the group consisting of â€”(CH2)nCR10R5R6 wherein n is an integer equal to 0, 1 or 2, R5 and R6 are independently selected from hydrogen, alkyl, alkenyl, aryl, heteroaryl, heterocyclic, â€”NR7R8 where R7 and R8 are independently hydrogen or alkyl and â€”COOR9 where R9 is alkyl, and further wherein R5 and R6 can be joined to form a cycloalkyl group, a cycloalkenyl group, an aryl group, a heteroaryl group, and a heterocyclic group, and when R5 and R6 do not join to form an aryl or heteroaryl group, then R10 is selected from hydrogen and alkyl with the proviso that when n is zero, then R10 is hydrogen and when n is greater than zero and R5 and R6 are joined to form an aryl or heteroaryl group, then R10 becomes a bond within that group; X is selected from the group consisting of oxygen and sulfur; Xâ€² is hydrogen, hydroxy or fluoro; Xâ€³ is hydrogen, hydroxy or fluoro, or Xâ€² and Xâ€³ together form an oxo group, and pharmaceutically acceptable salts thereof with tile proviso that: when R1 is pyrid-3-yl, R2 is ethyl, X is oxygen, and Xâ€² and Xâ€³ are hydrogen, then R3 is not â€”CH2CH(CH3)2.