Patent ID: 6171617
Filing Date: 2001-01-09
Classification: A61K,Y10S

Abstract:
An effervescent ibuprofen formulation containing two, separately produced granules:(a) ibuprofen granules, prepared from ibuprofen acid and a basic adjuvant in a molar ratio of 1 mole of ibuprofen acid to 0.5-10 mole of basic adjuvant, wherein at least 70% of the basic ibuprofen granules (a) are present in a grain size in the range of 0.1 and 2.0 mm, and(b) ibuprofen-free effervescent granules, containing an acid component and a carbon-dioxide generating component,wherein said effervescent formulation has a molar ratio of the ibuprofen acid to the acid component of the effervescent granules (b) in the range of 1 mole of ibuprofen acid to 0.5-6 mole of acid component and the molar ratio of the ibuprofen acid to the carbon dioxide generating component of the effervescent granules (b) is in the range of 1 mole of ibuprofen acid to 1-30 mole of the carbon dioxide generating component, andwherein upon disintegration of the ibuprofen effervescent formulation, the effervescent granules (b) dissolve upon contact with water immediately to release ibuprofen granules (a), from which ibuprofen subsequently dissolves.