Patent ID: 6064945
Filing Date: 2000-05-16
Classification: G01N

Abstract:
On a computer system, a method of determining molecular weight distribution (MWD) of a sample processed using gel permeation chromatography apparatus, said method comprising:obtaining first data from a first detector detecting said sample;obtaining a parameterized model describing sample properties;choosing initial values for parameters for said parameterized model;constructing an initial curve from said first data, from said parameterized model, and from said initial values;obtaining second data from a second detector detecting said sample;determining a best fit curve and best fit parameter values from said initial curve, from said parameterized model, and from said second data to provide a molecular weight calibration for said chromatography apparatus; andobtaining a concentration profile of said sample using said chromatography apparatus, and using said molecular weight calibration and said concentration profile to determine said MWD.