Patent ID: 7635474
Filing Date: 2009-12-22
Classification: A61K,A61P,C07K

Abstract:
1. An article of manufacturing comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent comprises at least one vascular endothelial growth factor (VEGF)-binding fusion protein and the VEGF-binding fusion protein consists of R1, R2, and a multimerizing component (MC) wherein R1 is VEGF receptor component Ig domain 2 of Flt-1 consisting of amino acids 27-126 of SEQ ID NO:8 or 27-129 of SEQ ID NO: 10, R2 is Ig domain 3 of Flk-1 consisting of amino acids 127-228 of SEQ ID NO: 8 or 130-231 of SEQ ID NO:10, and MC comprises the amino acid sequence of SEQ ID NO:11.