Patent ID: 6531457
Filing Date: 2003-03-11
Classification: C07H

Abstract:
A pharmaceutical composition comprising a compound of the formula (I): wherein(a) each R is individually hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl or phenyl(C1-C3)-alkyl; (b) X is â€”CH2OH, â€”CO2R2, â€”OC(O)R2, CH2OC(O)R2 or C(O)NR3R4; (c) each of R2, R3 and R4 is individually H, C1-6-alkyl; C1-6-alkyl substituted with 1-3 C1-6-alkoxy, C3-C7 cycloalkyl, C1-6-alkylthio, halogen, hydroxy, amino, mono(C1-6-alkyl)amino, di(C1-6-alkyl)amino, or C6-10-aryl, wherein aryl may be substituted with 1-3 halogen, C1-6-alkyl, hydroxy, amino, mono(C1-6-alkyl)amino, or di(C1-6-alkyl)amino; C6-10-aryl; or C6-10-aryl substituted with 1-3 halogen, hydroxy, amino, mono(C1-6-alkyl)amino, di(C1-6-alkyl)amino or C1-6-alkyl; (d) R1 is (Xâ€”(Z)â€”)n((C3-C10)cycloalkyl)- (Zâ€²)- wherein Z and Zâ€² are individually (C1-C6)alkyl, optionally interrupted by 1-3 S or nonperoxide O, or is absent, and n is 1-3; or a pharmaceutically acceptable salt thereof; in combination with a liquid carrier; wherein the composition can be intravenously administered.