Patent ID: 6780642
Filing Date: 2004-08-24
Classification: A61P,C12Q

Abstract:
A method of decreasing SIM2 short form gene expression comprising the steps of:(a) providing a cell that expresses a SIM2 short form nucleic acid having the sequence of SEQ ID NO:2; and (b) introducing into the cell an agent that decreases the expression of a nucleic acid having the sequence of SEQ ID NO: 2 or the complement of SEQ ID NO: 2 in the cell, wherein the agent is an oligonucleotide that hybridizes under stringent conditions to a nucleic acid having the sequence of SEQ ID NO: 2 or the complement of SEQ ID NO: 2, said oligonucleotide being selected from the group consisting of an antisense oligonucleotide, a ribozyme, and a triple-helix forming molecule.