Patent ID: 9034871
Filing Date: 2015-05-19
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A compound selected from: 3-[3-(5-tert-Butyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl)-phenyl] propionic acid; 3-[3-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl)-phenyl]propionic acid; 5-t-Butyl-2-phenyl-1-[3-(1H-tetrazol-5-yl) phenyl]-4,5,6,7-tetrahydro-1H-indole; 3-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzamide; 4-[4-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]butyric acid; 3-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzenesulfonamide; 3-(5-t-Butyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) N-methyl benzamide; 4-[4-(5-t-Butyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]butyric acid; 4-methyl-2-phenyl-1-[3-(1H-tetrazol-5-yl) phenyl]-4,5,6,7-tetrahydro-1H-indole; 3-[5-(1,1-dimethylpropyl)-2-phenyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-(2-phenyl-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 5-ethyl-2-phenyl-1-[3-(1H-tetrazol-5-yl)-phenyl]-4,5,6,7-tetrahydro-1H-indole; 2-phenyl-1-[3-(1H-tetrazol-5-yl)-phenyl]-5-trifluoromethyl-4,5,6,7-tetrahydro-1H-indole; 3-[3-(5-ethyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl)-phenyl]propionic acid; 3-(5-ethoxycarbonyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[5-(t-Butyldimethylsilyl)-2-phenyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-(5-carboxy-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[3-(4-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]propionic acid; 3-[3-((R)-6-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]propionic acid; 3-[3-(6,6-dimethyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]propionic acid; 5-methyl-2-phenyl-1-[3-(1H-tetrazol-5-yl) phenyl]-4,5,6,7-tetrahydro-1H-indole; N-methyl-3-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzamide; 3-[3-(5-ethoxycarbonyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl)-phenyl]propionic acid; 1-[3-(2-carboxy-ethyl)-phenyl]-2-phenyl-4,5,6,7-tetrahydro-1H-indole-5-carboxylic acid ethyl ester; 3-[3-(2-phenyl-5-propyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]propionic acid; 3-(5-hydroxy-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; [3-(5-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]morpholin-4-yl-methanone; 3-(2-phenyl-4-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-(2-phenyl-6-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-{4-[4-(ethoxycarbonyl)phenyl]-2-phenyl-4,5,6,7-tetrahydroindol-1-yl}benzoic acid; 3-{6-[4-(ethoxycarbonyl)phenyl]-2-phenyl-4,5,6,7-tetrahydroindol-1-yl}benzoic acid; 3-[2-(3,4-dichlorophenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-(5-oxo-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[2′-phenyl-4′,5′,6′,7′-tetrahydrospiro(1,3-dioxolane-2,5′-indol)-1′-yl]benzoic acid; 3-(5-cyclohexyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 5-[1-(3-carboxyphenyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indol-4-yl]-furan-2-carboxylic acid ethyl ester; 5-[1-(3-carboxyphenyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indol-6-yl]-furan-2-carboxylic acid ethyl ester; 3-[2-(3,4-dichlorophenyl)-4-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[2-(3,4-dichlorophenyl)-6-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 4-{4-[5-(1,1-dimethylpropyl)-2-phenyl-4,5,6,7-tetrahydroindol-1-yl]-phenyl}butyric acid; 4-[4-(6-methyl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) phenyl]butyric acid; 3-[5-(1,1-dimethylpropyl)-2-phenyl-4,5,6,7-tetrahydroindol-1-yl]4-hydroxybenzoic acid; 2-chloro-5-[5-(1,1-dimethylpropyl)-2-phenyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-(5-benzyloxy-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[2-(3,4-dimethoxyphenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]-benzoic acid; 3-[2-(2,4-dimethoxyphenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[2-(4-morpholin-4-yl-phenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[5-trifluoromethyl-2-(2,3,4-trimethoxyphenyl)-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-(5-diethylamino-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-(5-morpholin-4-yl-2-phenyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-(2-phenyl-5-pyrrolidin-1-yl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[2-(4-chlorophenyl)-5-(1,1-dimethylpropyl)-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[5-(1,1-dimethylpropyl)-2-(3-trifluoromethylphenyl)-4,5,6,7-tetrahydro-indol-1-yl]benzoic acid; 3-[5-(1,1-dimethylpropyl)-2-(4-fluoropheny)-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[5-(1,1-dimethylpropyl)-2-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-indol-1-yl]benzoic acid; 5-morpholin-4-yl-1,2-diphenyl-4,5,6,7-tetrahydro-1H-indole; 3-[2-(3-chlorophenyl)-5-(1,1-dimethylpropyl)-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[2-(3,4-dichlorophenyl)-5-(1,1-dimethylpropyl)-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-[2-(4-nitrophenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; 3-amino-5-(2-phenyl-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; 3-[2-(4-aminophenyl)-5-trifluoromethyl-4,5,6,7-tetrahydroindol-1-yl]benzoic acid; or 3-(2-phenyl-6-pyridin-2-yl-4,5,6,7-tetrahydroindol-1-yl) benzoic acid; and pharmaceutically-acceptable salts thereof.