Patent ID: 6077849
Filing Date: 2000-06-20
Classification: A61K,C07D

Abstract:
A compound represented by formula I: ##STR73## or a tautomer, salt, hydrate, prodrug or reduced form thereof wherein: ring Y represents a 5-6 membered aryl or heteroaryl fused ring, which is optionally substituted with 1-4 groups selected from R.sup.a ;X represents O, S(O).sub.m or N, wherein m is 0, 1 or 2;A represents a member selected from the group consisting of:(a) a 6-10 membered mono-or bicyclic aryl group;(b) a 5-6 membered isolated monocyclic heteroaryl group;(c) a 9-10 membered bicyclic heteroaryl group, attachment to which is through a 6 membered ring, or(d) an 8-membered bicyclic heteroaryl group, the heteroaryl groups having 1-4 heteroatoms selected from O, S(O).sub.m and N,said aryl and heteroaryl groups being optionally substituted with 1-3 R.sup.a groups;each R.sup.a is independently selected from the group consisting of:halo, --OH, --C.sub.1-12 alkyl(R.sup.b).sub.3, --C.sub.2-10 alkenyl(R.sup.b).sub.3, --C.sub.2-10 alkynyl(R.sup.b).sub.3, --C.sub.6-10 aryl(R.sup.b).sub.3, -heteroaryl(R.sup.b).sub.3 ,-heterocyclyl(R.sup.b).sub.3, --NH.sub.2, --NHC.sub.1-6 alkyl(R.sup.b).sub.3, --N(C.sub.1-6 alkyl(R.sup.b).sub.3).sub.2, --N.sub.3, --OC.sub.1-6 alkyl(R.sup.b).sub.3, --S(O).sub.m H, --S(O).sub.m C.sub.1-6 alkyl(R.sup.b).sub.3, --CHO, --C(O)C.sub.1-6 alkyl(R.sup.b).sub.3, --CO.sub.2 H, --C(O)OC.sub.1-6 alkyl(R.sup.b).sub.3, --C(O)SC.sub.1-6 alkyl(R.sup.b).sub.3, --C(O)NH.sub.2, --C(O)NHC.sub.1-6 alkyl(R.sup.b).sub.3, --NHC(O)C.sub.1-6 alkyl(R.sup.b).sub.3, --S(O).sub.m NH.sub.2, --NHS(O).sub.m C.sub.1-6 alkyl(R.sup.b).sub.3, --S(O).sub.m NHC.sub.1-6 alkyl(R.sup.b).sub.3 and --S(O).sub.m N(C.sub.1-6 alkyl(R.sup.b).sub.3).sub.2,and each R.sup.b is independently selected from: H, OH, halo, --C.sub.1-4 alkyl, --C.sub.2-4 alkenyl, --C.sub.2-4 alkynyl, --CF.sub.3, --OCF.sub.3, --NO.sub.2, --N.sub.3, --CHO, --OC.sub.1-6 alkyl, --S(O).sub.m C.sub.1-6 alkyl, --NH.sub.2, --NHC.sub.1-6 alkyl, --N(C.sub.1-6 alkyl).sub.2, --C(O)C.sub.1-6 alkyl, --CO.sub.2 H, --CO.sub.2 C.sub.1-6 alkyl, --C(O)NH.sub.2, --C(O)NHC.sub.1-6 alkyl, --C(O)N(C.sub.1-6 alkyl).sub.2, --OC(O)C.sub.1-6 alkyl, --NHC(O)C.sub.1-6 alkyl, --S(O).sub.m NH.sub.2, --S(O).sub.m NHC.sub.1-6 alkyl, --S(O).sub.m (C.sub.1-6 alkyl).sub.2, aryl, heteroaryl and heterocyclyl.