Patent ID: 6136845
Filing Date: 2000-10-24
Classification: A61K,A61P

Abstract:
A method of inhibiting the growth of estrogen-dependent tumors comprising administering to a patient in need of such treatment an enhanced therapeutically effective amount of a first compound of the formula: ##STR3## wherein R.sub.1, R.sub.3, R.sub.6 and R.sub.8 or R.sub.2, R.sub.4, R.sub.6 and R.sub.8 are individually and independently a hydrogen or a substituent selected from the group consisting of chlorine, fluorine, and bromine, and a linear or branched alkyl group of one to four carbons, said first compound having at least one alkyl substituent and at least two halogen substituents; anda therapeutically effective amount of a second compound which is a triphenylethylene antiestrogen which is tamoxifen.