Patent ID: 6635630
Filing Date: 2003-10-21
Classification: C07C,C07D,C07F

Abstract:
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are independently â€ƒX1 is â€”Oâ€”, â€”NR12â€”, â€”N(COR12)â€” or â€”N(SO2R15)â€”; R1, R2, R3 and R7 are each independently selected from the group consisting of H, C1-C6 alkyl, hydroxy(C1-C3)alkyl, C3-C8 cycloalkyl, â€”CH2F, â€”CHF2 and â€”CF3; or R1 and R2, together with the carbon to which they are attached, form a C3-C6 alkylene ring; each R6 is independently selected from H, C1-C6 alkyl, â€”OR13 or â€”SR12; n is 1; â€ƒis selected from the group consisting of X2 is â€”NR5â€”; Y1 is H, C1-C6 alkyl, â€”NR17R13, â€”SCH3, R19-aryl(CH2)n6â€”, R19-heteroaryl-(CH2)n6â€”, â€”(CH2)n6-heterocycloalkyl, â€”(C1-C3)alkyl-NHâ€”C(O)O(C1-C6)alkyl or â€”NHC(O)R15; R5 is H or â€”(CH2)n1â€”G, wherein n1 is 0-5, G is H, â€”CF3, â€”CHF2, â€”CH2F, â€”OH, â€”Oâ€”(C1-C6 alkyl), â€”SO2R13, â€”Oâ€”(C3-C8 cycloalkyl), â€”NR13R14, â€”SO2NR13R14, â€”NR13SO2R15, â€”NRâ€”COR12, â€”NR12(CONR13R14), â€”CONR13R14, â€”COOR12, C3-C8 cycloalkyl, R19-aryl, â€ƒor when n1 is 0, R5 can also be â€”C(O)R13 or â€”C(S)R13; provided that G is not H when n1=0; X is â€”CF2â€”, â€”CH2â€” or â€”CR12Fâ€”; R8, R9 and R10 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, â€”OR12, halogen, â€”CN, â€”NO2, â€”CF3, â€”CHF2, â€”CH2F, â€”OCF3, â€”OCHF2, â€”OCH2F, â€”COOR12, â€”CONR21R22, â€”NR21COR12, â€”NR21CO2R15, â€”NR21CONR21R22, â€”NR21SO2R15, â€”NR21R22, â€”SO2NR21R22, â€”S(O)n5R15, R16-aryl and R19-heteroaryl; R11 is H, C1-C6 alkyl, C3-C8 cycloalkyl, â€”NO2, â€”CN, OH, â€”OR12, â€”O(CH2)n6R12, â€”(C1-C3)alkyl-C(O)NHR12, R19-aryl(CH2)n6â€” or R19-heteroaryl-(CH2)n6â€”; R4 and R12 are each independently selected from the group consisting of H, C1-C6 alkyl and C3-C8 cycloalkyl; R13 and R14 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, R19-aryl(CH2)n6â€” or R19-heteroaryl-(CH2)n6â€”; R15 is C1-C6 alkyl, C3-C8 cycloalkyl or â€”CF3; R16 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, halogen and â€”CF3; R19 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, â€”OH, halogen, â€”CN, â€”NO2, â€”CF3, â€”CHF2, â€”CH2F, â€”OCF3, â€”OOHF2, â€”OCH2F, â€”Oâ€”(C1-C6 alkyl), â€”Oâ€”(C3-C8 cycloalkyl), â€”COOR12, CONR21R22, â€”NR21R22, â€”NR21COR12, â€”NR21CO2R12, â€”NR21CONR21R22, â€”NR21SO2R15 and â€”S(O)n5R15; R21 and R22 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl and benzyl; n3 and n4 are independently 1-5, provided that the sum of n3 and n4 is 2-6; and n6 is independently 0-3; wherein heteroaryl means a 5- to 10-membered single or benzofused aromatic ring consisting of 4 to 6 carbon atoms and 1 to 4 heteroatoms independently selected form the group consisting of â€”0â€”, â€”Sâ€”, â€”N&boxH;, and â€”NHâ€”, provided that the rings do not include adjacent oxygen and/or sulfur atoms.