Patent ID: 6117453
Filing Date: 2000-09-12
Classification: A61K,Y10S

Abstract:
A solid pharmaceutical composition comprising, by weight based on the total weight of the composition:(a) from 5 to 45% of an active ingredient which is not in an amorphous form selected from the group consisting of acyclovir, nifedipine, nicardipine, captopril, verapamil, diltiazem, oxybutynine, valacyclovir, glipizide, felodipine, isosorbide, carbidopa, levodopa and pentoxiphylline;(b) from 25 to 70% polyethylene oxide;(c) the balance consisting of conventional additives, excluding basic components,said composition being obtained by the process, comprising the steps consisting of:(i) mixing in the dry state and for a sufficient time, an active ingredient, polyethylene oxide and optionally, one or several additives;(ii) adding solvent, followed by mixing for a sufficient period of time;(iii) granulation;(iv) drying the granules thus formed for a sufficient period of time;(v) optionally adding one or more additives, with mixing in the dry state for a sufficient time and passage through a suitable sieve;(vi) optionally adding one or several additives and mixing in the dry state for a sufficient period of time;(vii) compressing the mixture obtained from the preceding steps to obtain the desired compressed tablet; and(viii) optionally coating said compressed tablet.