Patent ID: 6027712
Filing Date: 2000-02-22
Classification: A61K,Y10S

Abstract:
A method for effecting the localized treatment of inflamed mucosal tissue lining a cavity within the ear, nose or sinuses comprising the steps of:(a) presenting an aerosol spray dispenser having a reservoir and a dispensing nozzle thereon, said reservoir containing a therapeutic composition comprising Interleukin-1 receptor antagonist dispersed in a pharmacologically acceptable fluid vehicle, said therapeutic composition being formulated for aerosol spray dispensation of said Interleukin-1 receptor antagonist consisting essentially of a protein having the amino acid sequence:Met Arg Pro Ser Gly Arg Lys Ser Ser Lys 5 10 - Met Gln Ala Phe Arg Ile Trp Asp Val Asx 15 20 - Gln Lys Thr Phe Tyz Leu Arg Asx Asx Gln 25 30 - Leu Val Ala Gly Tyr Leu Gln Gly Pro Asx 35 40 - Val Asp Leu Glu Glu Lys Ile Asp Val Val 45 50 - Pro Ile Glu Pro His Ala Leu Phe Leu Gly 55 60 - Ile His Gly Gly Lys Met Cys Leu Ser Cys 10 65 70 - Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 75 80 - Leu Glu Ala Val Asp Ile Thr Asp Leu Ser 85 90 - Glu Asp Arg Lys Gln Asp Lys Arg Phe Ala 95 100 - Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 105 110 - Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 115 120 - Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 125 130 - Pro Val Ser Leu Thr Asp Met Pro Asp Glu 135 140 - Gly Val Met Val Thr Lys Phe Tyr Phe Glx 145 150 - Glu Asp Glu; (b) placing the dispensing nozzle in fluid communication with the cavity; and(c) spraying the therapeutic composition into the cavity until at least a portion of the therapeutic composition impinges upon said inflamed mucosal tissue.