Patent ID: 6562846
Filing Date: 2003-05-13
Classification: A61P,C07D

Abstract:
Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereofwhereinR1 are R2 are each independently H, C1-3 alkyl or halo; R3 is C1-C3alkyl or C3-7cycloalkyl; A is L; L is -phenyl-Oâ€”C1-4alkylene wherein said C1-4alkylene is attached to D; provided that if A is L, then D is X(O)O and Aâ€”D is not interrupted with Jâ€”Jâ€², â€”Z-phenyl- or â€”Zâ€”C1-3alkylene; D is X(O)O, X(O)N(Gâ€²), HYC(O)O or HYC(O)ON&boxH;C(Gâ€²); X is C and is attached to A; Y is N and is attached to A; G is H, C1-5alkyl, C1-5haloalkyl, C3-7cycloalkyl, phenyl, â€”C1-2alkylene-phenyl, C-pyridyl or N-pyridyl, said phenyl or â€”C1-2alkylene-phenyl are each optionally and independently substituted with one or more of the same or different substitutents selected from the group consisting of halo, NO2, CN, â€”C(O)Oâ€”C1-3-alkyl, C1-3alkyl, hydroxy and C1-3alkoxy; Gâ€² is H, C1-5alkyl or C1-5haloalkyl; and wherein Aâ€”D is optionally interrupted with Jâ€”Jâ€², â€”Z-phenyl- or â€”Zâ€”C1-3alkylene; â€ƒwherein Z is O or S and is attached to A; J is CH and is attached to A, D and Jâ€²; Jâ€² is C1-4alkyl or phenyl; provided thatif Aâ€”D is interrupted with â€”Z-phenyl-, then A is C1-5 alkylene; if Aâ€”D is not interrupted with â€”Z-phenyl-, then A is C5-12 alkylene.