Patent ID: 6469065
Filing Date: 2002-10-22
Classification: A61K,C07C,C07D

Abstract:
A compound of formula (VIII): whereinRt and Ru are each independently a hydrogen, a lower alkyl, a cycloalkyl, or an aryl; Rk is hydrogen or a lower alkyl; Râ€²k is a lower alkyl; a is an integer of 2 or 3; D is: (i) â€”NO; (ii) â€”NO2; or (iii) â€”C(Rd)â€”Oâ€”C(O)â€”Yâ€”Zâ€”(C(Re)(Rf))pâ€”Tâ€”Q; Rd is a hydrogen, a lower alkyl, a cycloalkyl, an aryl or an arylalkyl; Y is oxygen, sulfur or NRi; Ri is a hydrogen or a lower alkyl; Re and Rf are each independently a hydrogen, a lower alkyl, a cycloalkyl, amido, alkyl amido, an amino, an alkylamino, an aryl, an arylalkyl, a carboxyl, or Re and Rf taken together with the carbon atoms to which they are attached are a carbonyl, a cycloalkyl group or a bridged cycloalkyl group; p is an integer from 1 to 6; T is independently a covalent bond, oxygen, sulfur or nitrogen; Z is a covalent bond, a lower alkyl, a cycloalkyl, an aryl, or an arylalkyl; and Q is â€”NO or â€”NO2.