Patent ID: 6855543
Filing Date: 2005-02-15
Classification: A61K,C07K

Abstract:
1. A composition comprising: (a) a plasmid DNA comprising in 5′ to 3′ direction, a GAL4 responsive element a promoter, and a polynucleotide encoding a transmembrane region and an apoptosis-inducing domain of a Fas antigen; and (b) a plasmid DNA encoding a fusion protein comprising in a 5′ to 3′ direction a GAL4 DNA binding region and a nuclear receptor ligand binding region selected from the group consisting of: amino acids 166 to 478 of human PPARγ1 subtype receptor, amino acids 194 to 506 of human PPARγ2 subtype receptor, amino acids 164 to 475 of mouse PPARγ1 subtype receptor, amino acids 194 to 505 of mouse PPARγ2 subtype receptor, amino acids 157 to 468 of human PPARα receptor, amino acids 157 to 468 of rat PPARα receptor, amino acids 129 to 441 of human PPARδ receptor, and amino acids 128 to 440 of mouse PPARδ receptor.