Patent ID: 6242616
Filing Date: 2001-06-05
Classification: A61P,C07B,C07C,C07D,C07F

Abstract:
A process for forming a tetraene of formula: ##STR139##wherein:R.sub.1, R.sub.2, R.sub.7, and R.sub.8 are independently C.sub.1 -C.sub.10 alkyl;R.sub.3, R.sub.6, and R.sub.16 are independently selected from hydrogen and C.sub.1 -C.sub.6 alkyl;R.sub.4 and R.sub.9 are independently an acid labile hydroxyl protecting group;R.sub.25 is an oxidatively labile protecting group; andJ is selected from: ##STR140## ##STR141##wherein R.sub.32 is C.sub.1 -C.sub.6 alkyl and R.sub.33 is an acid labile hydroxyl protecting group;the process comprising contacting a compound of the formula:J--CHOwith a phosphonium salt of the formula: ##STR142##wherein R.sub.18 is C.sub.6 -C.sub.14 aryl, in the presence of a base for a time and under conditions effective to form the tetraene.