Patent ID: 6063940
Filing Date: 2000-05-16
Classification: C07C,C07F

Abstract:
A process for preparing a phenylalkene derivative of the formula: ##STR12## wherein R.sup.1, R.sup.2, R.sup.3 independently represent a hydrogen atom, a halogen atom, a lower alkyl group containing 1 to 5 carbon atoms or a lower alkoxy group containing 1 to 5 carbon atoms, or R.sup.1 and R.sup.2 together form a methylenedioxy group or an ethylenedioxy group when R.sup.3 is a hydrogen atom, and n is an integer of 1 to 10, comprising the steps of:reacting an alkenyl halide of the formula:CH.sub.2 .dbd.CH--(CH.sub.2).sub.n-1 --X (III)wherein X represents a chlorine atom or a bromine atom, and n is the same as defined above, with metal magnesium to form a Grignard reagent of the formula:CH.sub.2 .dbd.CH--(CH.sub.2).sub.n-1 --MgX (IV)wherein X and n are the same as defined above; andthen reacting the Grignard reagent of the formula (IV) with a benzyl halide derivative of the formula: ##STR13## wherein R.sup.1, R.sup.2, R.sup.3 and X are the same as defined above, to form the phenylalkene derivative of the formula (II), wherein the reaction of said Grignard reagent of the formula (IV) with said halide derivative of the formula (V) is carried out in the presence of a nickel catalyst.