Patent ID: 6861526
Filing Date: 2005-03-01
Classification: A61P,C07D

Abstract:
1. A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine comprising the steps of: contacting a compound containing a mixture of R- and S-isomers and having the formula with an effective amount of a chiral organic acid in the presence of an organic solvent and an effective amount of an organic carboxylic acid for converting said R-isomer into an acid salt of said S isomer, said organic solvent being capable of solubilizing said compound containing said mixture of R- and S-isomers, while precipitating said acid salt and said organic carboxylic acid being different from said chiral organic acid; neutralizing said acid salt with a base to provide an S-isomer of a chiral ketone of the formula reacting said chiral ketone with an organic amine in the presence of a Lewis acid to provide the corresponding imine and reducing said imine.