Patent ID: 6669956
Filing Date: 2003-12-30
Classification: A61K

Abstract:
A direct compression process for producing a tablet comprising the following steps:(a) mixing an initial formulation comprising an isoflavone-containing plant extract, a water-insoluble polysaccharide, wherein the amount of the water-insoluble polysaccharide in the tablet comprises at least about 15% of the dry weight of the tablet, a filler, and a silica gel glidant wherein the amount of the silica gel in the tablet comprises between about 1% to about 5% of the dry weight of the tablet; (b) milling the mixed formulation; (c) mixing into the milled and mixed formulation a micronized stearic acid, wherein the amount of the micronized stearic acid in the tablet comprises between about 1% to about 5% of the dry weight of the tablet; and (d) pressing the milled formulation into a tablet form, wherein the compression force of the press on the tablet is at least about 15 kilopounds.