Patent ID: 8580946
Filing Date: 2013-11-12
Classification: A61P,C12N

Abstract:
1. A multi-conjugate of siRNA having the following structure of [Structure Formula I] prepared by direct or indirect covalent bonding of double-stranded sense/antisense siRNA monomers mediated by a cross-linking agent or a polymer: wherein, X is a double-stranded siRNA monomer having a sense strand and an antisense strand; A, a cross-linking agent or a polymer; and n is the number of double-stranded siRNA monomers and is one of 2-100, wherein the multi-conjugate of siRNA has a direct covalent bonding or an indirect covalent bonding between one end of a sense strand of one double-stranded siRNA monomer and one end of an antisense strand of its neighbor double-stranded siRNA monomer.