Patent ID: 9156914
Filing Date: 2015-10-13
Classification: A61K,C07K

Abstract:
1. A compound or VHH construct, that comprises or essentially consists of: a) an amino acid sequence that specifically binds to A Disintegrin And Metalloprotease Thrombospondin 5 (ADAMTS5), and inhibit the proteinase activity of ADAMTS5, and that essentially consists of a VHH sequence, which consists of 4 framework regions (FR1 to FR4 respectively) and 3 complementarity determining regions (CDR1 to CDR3 respectively), in which: CDR1 is SEQ ID NO: 313, CDR2 is SEQ ID NO: 525 and CDR3 is SEQ ID NO: 737; CDR1 is SEQ ID NO: 314, CDR2 is SEQ ID NO: 526 and CDR3 is SEQ ID NO: 738; CDR1 is SEQ ID NO: 315, CDR2 is SEQ ID NO: 527 and CDR3 is SEQ ID NO: 739; CDR1 is SEQ ID NO: 316, CDR2 is SEQ ID NO: 528 and CDR3 is SEQ ID NO: 740; CDR1 is SEQ ID NO: 317, CDR2 is SEQ ID NO: 529 and CDR3 is SEQ ID NO: 741; CDR1 is SEQ ID NO: 318, CDR2 is SEQ ID NO: 530 and CDR3 is SEQ ID NO: 742; CDR1 is SEQ ID NO: 319, CDR2 is SEQ ID NO: 531 and CDR3 is SEQ ID NO: 743; CDR1 is SEQ ID NO: 320, CDR2 is SEQ ID NO: 532 and CDR3 is SEQ ID NO: 744; CDR1 is SEQ ID NO: 321, CDR2 is SEQ ID NO: 533 and CDR3 is SEQ ID NO: 745; CDR1 is SEQ ID NO: 322, CDR2 is SEQ ID NO: 534 and CDR3 is SEQ ID NO: 746; CDR1 is SEQ ID NO: 323, CDR2 is SEQ ID NO: 535 and CDR3 is SEQ ID NO: 747; CDR1 is SEQ ID NO: 324, CDR2 is SEQ ID NO: 536 and CDR3 is SEQ ID NO: 748; CDR1 is SEQ ID NO: 325, CDR2 is SEQ ID NO: 537 and CDR3 is SEQ ID NO: 749; CDR1 is SEQ ID NO: 326, CDR2 is SEQ ID NO: 538 and CDR3 is SEQ ID NO: 750; CDR1 is SEQ ID NO: 327, CDR2 is SEQ ID NO: 539 and CDR3 is SEQ ID NO: 751; CDR1 is SEQ ID NO: 328, CDR2 is SEQ ID NO: 540 and CDR3 is SEQ ID NO: 752; CDR1 is SEQ ID NO: 329, CDR2 is SEQ ID NO: 541 and CDR3 is SEQ ID NO: 753; CDR1 is SEQ ID NO: 330, CDR2 is SEQ ID NO: 542 and CDR3 is SEQ ID NO: 754; CDR1 is SEQ ID NO: 331, CDR2 is SEQ ID NO: 543 and CDR3 is SEQ ID NO: 755; CDR1 is SEQ ID NO: 332, CDR2 is SEQ ID NO: 544 and CDR3 is SEQ ID NO: 756; CDR1 is SEQ ID NO: 333, CDR2 is SEQ ID NO: 545 and CDR3 is SEQ ID NO: 757; CDR1 is SEQ ID NO: 334, CDR2 is SEQ ID NO: 546 and CDR3 is SEQ ID NO: 758; CDR1 is SEQ ID NO: 335, CDR2 is SEQ ID NO: 547 and CDR3 is SEQ ID NO: 759; CDR1 is SEQ ID NO: 336, CDR2 is SEQ ID NO: 548 and CDR3 is SEQ ID NO: 760; CDR1 is SEQ ID NO: 337, CDR2 is SEQ ID NO: 549 and CDR3 is SEQ ID NO: 761; or CDR1 is SEQ ID NO: 993, CDR2 is SEQ ID NO: 1013 and CDR3 is SEQ ID NO: 1033; and further comprises b) a serum protein, a VHH that specifically binds to human serum albumin, or an Fc portion.