Patent ID: 6274623
Filing Date: 2001-08-14
Classification: A61P,C07D

Abstract:
A compound having the formula ##STR8##where R.sup.1 and R.sup.1 ' are di- or polysubstituted aralkyl or aralkenyl; provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy; R.sub.2 and R.sub.2 ' are alkyl or alkenyl; A is normal or substituted alkanedicarbonyl, alkenedicardonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, polycycloalkenedicarbonyl, or aromatic dicarbonyl: N is 0, 1, or 2; m is 0, 1, or 2, p is 0, 1 or 2; R.sub.3 and R.sub.3 ' are H, CH.sub.3, or lower alkyl; R.sub.4 and R.sub.4 ' are H, CH.sub.3, or lower alkyl; R.sub.3 and R.sub.4 , together can also be -(CH.sub.2).sub.g -, -CH=CH-, -(CH.sub.2).sub.h - ##STR9##or --(CH.sub.2).sub.h S--(CH.sub.2).sub.k --, where g is 2,3,4, or 5, h is 1 or 2, and k is 1 or 2; and R.sub.3 ' and R.sub.4 ' can also be -(CH.sub.2).sub.g -, CH=CH-, -(CH.sub.2).sub.h -O-(CH.sub.2).sub.k, ##STR10##or --(CH.sub.2.sub.h --S--(CH.sub.2).sub.k --, where g is 2,3,4, or 5, h is 1 or 2, and k is 1 or 2; wherein R.sub.1 and R.sub.1 ', R.sub.2 and R.sub.2 ', R.sub.3 and R.sub.3 ', R.sub.4 and R.sub.4 ' can be the same or different; and X is a pharmaceutically acceptable anion.