Patent ID: 6649410
Filing Date: 2003-11-18
Classification: A61K,C07K,C12N

Abstract:
A method of assay for a retroviral antibody comprising:a) obtaining a sample suspected of containing a retroviral antibody; b) obtaining an inactive retroviral particle comprising inactivated reverse transcriptase, wherein said reverse transcriptase has been inactivated by a method comprising binding said reverse transcriptase with one or more compounds that binds said reverse transcriptase and then irradiating said HIV particles; c) contacting the sample with the inactive retroviral particle under conditions sufficient to allow the formation of a specific immunocomplex comprising the inactive retroviral particle and any retroviral antibody that may be in the sample; and d) assaying for the specific immunocomplex wherein the presence or abundance of the immunocomplex indicates the presence or abundance of retroviral antibody.