Patent ID: 9102664
Filing Date: 2015-08-11
Classification: A61P,C07B,C07C,C07D

Abstract:
1. A process for the preparation of triazole derivative compound of Formula-1 comprising: a) reacting a compound of Formula-16 with ethyl magnesium halide in the presence of bis(trimethylsilyl)acetamide in a solvent to provide a compound of Formula-17, b) reacting the compound of Formula-17 in-situ with a compound of Formula-19 in the presence of a base in a solvent to provide a compound of Formula-20, c) condensing the compound of Formula-20 with a compound of Formula-10 in the presence of a base in a polar aprotic solvent to provide a compound of Formula-21, d) debenzylating the compound of Formula-21 with Pd/C under hydrogen pressure in the presence of mineral acid in an alcoholic solvent to provide the compound of Formula-1; and e) optionally, purifying the compound of Formula-1 obtained in step-(d) from a solvent to provide pure compound of Formula-1.