Patent ID: 8367062
Filing Date: 2013-02-05
Classification: A61K,A61P,C12N

Abstract:
1. A method of detection in vitro of a subject suffering from a pancreatic pathology, comprising contacting a biological sample from the subject with an antibody and detecting the formation of immunological complexes resulting from the immunological reaction between said antibody and said biological sample; wherein said antibody is a monoclonal antibody selected from the group consisting of monoclonal antibody 16D10 or an antigen binding fragment thereof having binding specificity for glycosylated bile salt dependent lipase (BSDL) or fetoacinar pancreatic protein (FAPP) and produced by the hybridoma deposited under the accession number I-3188; a monoclonal antibody, or an antigen binding fragment thereof, which competes with monoclonal antibody 16D10 for binding to BSDL or FAPP; and a derivative of the 16D10 monoclonal antibody selected from the group consisting of a chimeric 16D10, humanized 16D10 or single chain scFv 16D10 antibody.