Patent ID: 6465215
Filing Date: 2002-10-15
Classification: A61K,C12N,C12Q

Abstract:
A method for determining the suitability of a candidate cell for transplantation into a damaged vertebrate brain for the purpose of repairing damage to the brain, wherein said method comprises:(i) selecting a candidate cell with a neural cell phenotype, or which differentiates into a cell with a neural cell phenotype; (ii) obtaining the gene expression profile of said candidate cell; (iii) identifying a gene expression profile common to a plurality of control cells known to be suitable for transplantation, wherein the gene expression profile common to said plurality of control cells is selected from the group consisting of: (a) at least one expressed gene selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, and SEQ ID NO. 5; (b) at least one non-expressed gene selected from the group consisting of SEQ ID NO. 6 and SEQ ID NO. 7; and (c) at least one expressed gene selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, and SEQ ID NO. 5, and at least one non-expressed gene selected from the group consisting of SEQ ID NO. 6 and SEQ ID NO. 7; (iv) comparing the gene expression profile of said candidate cell with the gene expression profile common to said plurality of control cells; and (v) identifying said candidate cell as being suitable for transplantation if said candidate cell shares the gene expression profile of said plurality of control cells.