Patent ID: 6638534
Filing Date: 2003-10-28
Classification: A61K,A61P

Abstract:
A unit dose composition capable of quickly releasing a medicinal substance at a targeted site in the intestine, comprising a core material containing a medicinal substance coated with a mixed film consisting essentially of a hydrophobic organic compound and an enteric polymer selected from the group consisting of an enteric acrylic copolymer, an enteric maleic copolymer and an enteric polyvinyl derivative, said mixed film having been deposited from solution, wherein the ratio of hydrophobic organic compound to enteric polymer is within a range of 30:70 to 80:20, and the coating ratio of the mixed film to core material is within a range of 20 to 300% by weight, wherein all of the core material in the composition has a coating with a ratio of hydrophobic organic compound to enteric polymer and a ratio of mixed film to core material which has been preselected so as to result in a product with a predetermined residency at acidic pH without release, and a predetermined residency at neutral or alkaline pH before release so as to quickly release the core material at a predetermined location in the intestinal tract of the subject to whom the composition is to be administered.