Patent ID: 6362317
Filing Date: 2002-03-26
Classification: C07K,G01N

Abstract:
An isolated or purified antibody or antigenically-reactive fragment thereof that binds to a C-terminal amino acid sequence of an H2A histone protein, said C-terminal amino acid sequence consisting of SQ(D/E/A)(I/L/Y/F) (SEQ ID NO: 1) that comprises a phosphorylated serine, wherin the antibody or antigenically reactive fragment thereof does not detectably bind to a C-terminal amino acid sequence of an H2A histone protein, said C-terminal amino acid sequence consisting of SQ(D/E/A)(I/L/Y/F) (SEQ ID NO: 1) that does not comprise a phosphorylated serine under conditions when the isolated or purified antibody or antigenically-reactive fragment thereof binds to the C-terminal amino acid sequence of an H2A histone protein, C-terminal amino acid sequence consisting of SQ(D/E/A)(I/L/Y/F) (SEQ ID NO: 1) that comprises a phosphorylated serine.