Patent ID: 8206748
Filing Date: 2012-06-26
Classification: A61K,A61P

Abstract:
1. A powdery composition for nasal administration comprising (i) a drug, (ii) one or more of a water-absorbing and gel-forming base material selected from the group consisting of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, hydroxyethyl cellulose, and sodium carboxymethyl cellulose and (iii) one or more of a water-absorbing and water-insoluble base material selected from the group consisting of crystalline cellulose, α-cellulose, cross-linked sodium carboxy-methyl cellulose, cross-linked starch, chitin and chitosan, wherein the content of the water-absorbing and gel-forming base material is about 5-40 wt% based on the total of the water-absorbing and water-insoluble base material and the water-absorbing and gel-forming base material, 70 wt % or more based on the drug is dispersed on or in the water-absorbing and water-insoluble base material and on or in the water-absorbing and gel-forming base material, the water-absorbing and water-insoluble base material and water-absorbing and gel-forming base material comprise particles, wherein the drug is dispersed more on or in the water-absorbing and water-insoluble base material than on or in the water-absorbing and gel-forming base material, wherein the powdery composition is obtained by a method comprising making an average particle diameter of the water-absorbing and water-insoluble base material larger than an average particle diameter of the water-absorbing and gel-forming base material, and wherein the water-absorbing and water-insoluble base material has an average particle diameter of 50-350 μm in at least 90 wt % based on the water-absorbing and water-insoluble particles, and the water-absorbing and gel-forming base material has an average particle diameter of 10-100 μm in at least 90 wt % based on the water-absorbing and gel-forming particles.