Patent ID: 6699871
Filing Date: 2004-03-02
Classification: A61K,A61P,C07D,Y10S

Abstract:
A compound of the formula I: wherein:Ar is phenyl which is unsubstituted or substituted with 1-5 of R3, wherein R3 is independently selected from the group consisting of: (1) halogen, (2) C1-6alkyl, which is linear or branched and is unsubstituted or substituted with 1-5 halogens, (3) OCl-6alkyl, which is linear or branched and is unsubstituted or substituted with 1-5 halogens, and (4) CN; X is selected from the group consisting of: (1) N, and (2) CR2; R1 and R2 are independently selected from the group consisting of: (1) hydrogen, (2) CN, (3) C1-10alkyl, which is linear or branched and which is unsubstituted or substituted with 1-5 halogens or phenyl, which is unsubstituted or substituted with 1-5 substituents independently selected from halogen, CN, OH, R4, OR4, NHSO2R4, SO2R4, CO2H, and CO2C1-6alkyl, wherein the CO2Cl-6alkyl is linear or branched, (4) phenyl which is unsubstituted or substituted with 1-5 substituents independently selected from halogen, CN, OH, R4, OR4, NHSO2R4, SO2R4, CO2H, and CO2C1-6alkyl, wherein the CO2C1-6alkyl is linear or branched, and (5) a 5- or 6-membered heterocycle which may be saturated or unsaturated comprising 1-4 heteroatoms independently selected from N, S and O, the heterocycle being unsubstituted or substituted with 1-3 substituents independently selected from oxo, OH, halogen, C1-6alkyl, and OC1-6alkyl, wherein the C1-6alkyl and OC1-6alkyl are linear or branched and optionally substituted with 1-5 halogens; R4 is C1-6alkyl, which is linear or branched and which is unsubstituted or substituted with 1-5 groups independently selected from halogen, CO2H, and CO2C1-6alkyl, wherein the CO2C1-6alkyl is linear or branched; and pharmaceutically acceptable salts thereof and individual diastereomers thereof.