Patent ID: 6875743
Filing Date: 2005-04-05
Classification: A61K

Abstract:
1. A cell adhesion inhibitory compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein: Z is selected from the group consisting of aliphatic acyl substituted with N-arylamido; heterocycloyl; substituted aralkylcarbonyl; heterocycloalkylcarbonyl; cycloalkylcarbonyl optionally fused with aryl; heterocycloalkoxycarbonyl; alkylaminocarbonyl; arylamino-carbonyl optionally substituted with bis(alkylsulfonyl)amino, alkoxycarbonylamino or alkenyl; aralkylamino-carbonyl optionally substituted with bis(alkylsulfonyl)amino, alkoxycarbonylamino or alkenyl; alkylsulfonyl; aralkylsulfonyl; arylsulfonyl; cycloalkylsulfonyl optionally fused with aryl; heterocyclylsulfonyl; heterocyclylalkylsulfonyl; aryloxycarbonyl; cycloalkyloxycarbonyl; heterocyclyloxycarbonyl; heterocyclylalkoxycarbonyl; mono or di-alkylaminocarbonyl optionally substituted with aryl; (alkyl)(aralkyl)aminocarbonyl; mono- or di-aralkylaminocarbonyl; mono- or di-arylaminocarbonyl; (aryl)(alkyl)aminocarbonyl; mono- or di-cycloalkylaminocarbonyl; heterocyclylaminocarbonyl; heterocyclylalkylaminocarbonyl; (alkyl)(heterocyclyl)aminocarbonyl; (alkyl)(heterocyclylalkyl)aminocarbonyl; (aralkyl)(heterocyclyl)aminocarbonyl; (aralkyl)(heterocyclylalkyl)aminocarbonyl; alkenoyl optionally substituted with aryl; alkenylsulfonyl optionally substituted with aryl; alkynoyl optionally substituted with aryl; alkynylsulfonyl optionally substituted with aryl; cycloalkenylcarbonyl; cycloalkenylsulfonyl; cycloalkylalkylsulfonyl; arylaroyl; biarylsulfonyl; alkoxysulfonyl; aralkoxysulfonyl; alkylaminosulfonyl; aryloxysulfonyl; arylaminosulfonyl; N-arylurea-substituted alkanoyl; N-arylurea-substituted alkylsulfonyl; cycloalkenyl-substituted carbonyl; cycloalkenyl-substituted sulfonyl; alkenoxycarbonyl optionally substituted with aryl; alkenoxysulfonyl optionally substituted with aryl; alkynoxycarbonyl optionally substituted with aryl; alkynoxysulfonyl optionally substituted with aryl; alkynylaminocarbonyl optionally substituted with aryl; alkenylaminocarbonyl optionally substituted with aryl; alkenylaminosulfonyl optionally substituted with aryl; alkynylaminosulfonyl optionally substituted with aryl; acylamino-substituted alkanoyl; acylamino-substituted alkylsulfonyl; aminocarbonyl-substituted alkanoyl; carbamoyl-substituted alkanoyl; carbamoyl-substituted alkylsulfonyl; heterocyclylaminosulfonyl; carboxyalkyl-substituted aralkoyl; carboxyalkyl-substituted aralkylsulfonyl; oxocarbocyclyl-fused aroyl; oxocarbocyclyl fused arylsulfonyl; heterocyclylalkanoyl; N′,N′-alkyl arylhydrazinocarbonyl; aryloxy-substituted alkanoyl; and heterocyclylalkylsulfonyl; Y Y each Y A A each A each R or R each R n is an integer from 0 to 8; and X is selected from the group consisting of provided that the compound of formula I is expressly not N-carboxymethyl-N-(phenylacetyl-L-leucyl-L-aspartyl-L phenylalanyl-L-prolyl)piperazine and expressly not phenylacetyl L leucyl-L-aspartyl-L-phenylalanyl-D-proline amide; and provided that Z is not pyridylcarbonyl, pyridylacetyl, phthalimido, 3-quinolinoyl, pyrazolylcarbonyl, or 2-pyrazinylcarbonyl, when Y