Patent ID: 8871908
Filing Date: 2014-10-28
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody, or an antigen binding fragment thereof, which specifically binds to trophoblast cell-surface antigen-2 (Trop-2), wherein the antibody comprises (a) a heavy chain variable (VH) region comprising (i) a VH complementary determining region one (CDR1) comprising the sequence SYGVH (SEQ ID NO: 30), GGSISSY (SEQ ID NO: 36), or GGSISSYGVH (SEQ ID NO: 37); (ii) a VH CDR2 comprising the sequence VIWTX (b) a light chain variable region (VL) comprising (i) a VL CDR1 comprising the sequence RASKSVSTSX