Patent ID: 8420686
Filing Date: 2013-04-16
Classification: A61K,A61P,C07D,C07F,C12N

Abstract:
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein: L is an aromatic group selected from the group consisting of: i. a bicyclic aryl or bicyclic heteroaryl, wherein the rings of said bicyclic ring system are fused or covalently attached, wherein each imidazole moiety is attached to a different ring of said bicyclic ring system and wherein at least one ring of said bicyclic is a 5- or 7-membered ring; ii. a tricyclic aryl or tricyclic heteroaryl, wherein the rings of said tricyclic ring system are covalently attached or a combination of fused and covalently attached and wherein each imidazole moiety is attached to a different ring of said tricyclic; iii. a tricyclic aryl or tricyclic heteroaryl, wherein the rings of said tricyclic ring system are fused and each of the three rings is aromatic, and wherein each imidazole moiety is attached to a different ring of said tricyclic; iv.  wherein ring B is a five to seven-membered heteroaryl; and Z is selected from the group consisting of: absent, O, S, S(O), S(O) v.  wherein each ring B vi.  wherein Z is independently selected from the group consisting of: O, S, S(O), S(O) vii. each A is independently a 5-7 membered aryl or heteroaryl, wherein said aryl or heteroaryl are optionally substituted; W is an aliphatic group containing zero to eight carbons; R R R Q and J are each independently selected from: R R R R R R m is 0, 1, or 2; n is 1, 2, 3, or 4; u and v at each occurrence are each independently 0, 1, 2, or 3; X is selected from O, S, S(O), SO R or alternatively two geminal R 7 groups can be taken together with the carbon atom to which they are attached to form a spiro, optionally substituted C 3 -C 8 cycloalkyl or optionally substituted heterocyclic ring.