Patent ID: 6677431
Filing Date: 2004-01-13
Classification: A61K,C07C

Abstract:
An antibacterial &bgr;-peptide having the following formula: whereinR1 is H, an alkyl group having 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R2 is an amine-containing alkyl group having the formula â€”(CH2)mNH2, wherein m=1, 2, 3, 4, or 5, (CH2)xNHC&boxH;NHNH2 wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine; R3 is H, an alkyl group having 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; X is â€”NH2, â€”OH, â€”NHR, or OR where R is alkyl, aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer; Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and n is 2, 3, 4, 5, 6, or 7; wherein at least one of X and Y is a polymer selected from the group consisting of polyurethane, polyetherurethane, polyester, silicone, polyamide, polyolefin, polystyrene, polypeptide, polysaccharide, cellulosic, and silk.