Patent ID: 7425563
Filing Date: 2008-09-16
Classification: A61K,A61P,C07D

Abstract:
1. A 4-substituted aryl-5-hydroxyisoquinolinone compound represented by a formula (1) wherein ring Ar denotes a phenyl group, naphthyl group, 5- or 6-membered aromatic heterocycle or its condensed ring, R1 denotes a hydrogen atom or halogen atom, R2 denotes a hydrogen atom, halogen atom, hydroxy group, lower alkyl group which may be substituted with halogen atom, cycloalkyl group which may be substituted with halogen atom, lower alkoxy group which may be substituted with halogen atom, aralkyloxy group which may have substituents, nitro group, amino group which may have substituents, aralkyl group which may have substituents, phenyl group which may have substituents, naphthyl group which may have substituents, or 5-or 6-membered heterocycle which may have substituents and its condensed ring, A denotes a C1˜C4 alkylene or C2˜C4 alkenylene, R3 denotes a hydrogen atom, lower alkyl group which may be substituted with halogen atom, or formula (2) wherein Q1 denotes a C1˜C4 alkylene, and R5 denotes a hydroxy group, lower alkoxy group which may be substituted with halogen atom, amino group which may have substituents, lower alkoxycarbonyl group or carboxy group, R4 denotes a lower alkyl group which may be substituted with halogen atom, cycloalkyl group which may have substituents, phenyl group which may have substituents, naphthyl group which may have substituents, or 5- or 6-membered heterocycle which may have substituents and its condensed ring, formula (3) wherein Q2 denotes a C1˜C4 alkylene, and R6 denotes a hydroxy group, lower alkoxy group which may be substituted with halogen atom, lower alkoxycarbonyl group, carboxy group, cycloalkyl group which may have substituents, cycloalkenyl group which may have substituents, phenyl group which may have substituents, naphthyl group which may have substituents, or 5- or 6-membered heterocycle which may have substituents and its condensed ring, or formula (4) wherein R7 and R8 denote identically or differently hydrogen atoms, lower alkyl groups which may be substituted with halogenatom, aralkyl groups which may have substituents, or R7 and R8 are bound together to form a 5- or 6-membered heterocycle which may have substituents and its condensed ring, or R3 with R4 are bound together to form a 5- or 6-membered heterocycle which may have substituents and its condensed ring, or a pharmacologically acceptable addition salt thereof.