Patent ID: 7514557
Filing Date: 2009-04-07
Classification: A61P,C07C,C07D,C07K

Abstract:
1. A process for preparing a compound of formula II: wherein Het is a five-, six- or seven-membered saturated or unsaturated heterocycle containing from one to four heteroatoms selected from nitrogen, oxygen and sulfur; said heterocycle being substituted with R 1 at any available position on the heterocycle; R R R R Alk is a C R wherein: A is O or NH; B is (C a) wherein said cycloalkyl, cycloalkylalkyl may be mono-, di- or tri-substituted with (C b) wherein said alkyl, cycloalkyl, cycloalkylalkyl may be mono- or di-substituted with substituents selected from hydroxy and (C c) wherein all said alkyl-groups may be mono-, di- or tri-substituted with halogen; and d) wherein said cycloalkyl-groups being 4-, 5-, 6- or 7-membered having optionally one (for the 4-, 5, 6, or 7-membered) or two (for the 5-, 6- or 7-membered) —CH R R wherein: R R or R said process comprising reacting a compound of formula QUIN, wherein X is an SO 2 R group, wherein R is C 1-6 alkyl, C 6 or C 10 aryl or heteroaryl, with a compound of formula P2 to obtain a compound of formula II: wherein Alk, Het, R 1 , R A and R B in formulas QUIN and P2 are the same as defined above for formula II.