Patent ID: 6121252
Filing Date: 2000-09-19
Classification: A61P,C07F

Abstract:
A compound of formula I ##STR43## or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein:X is CR.sub.6 R.sub.7, O, or NR.sub.8 ;Y is C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.1, wherein Y is unsubstituted or substituted with one or more substituent(s);R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, Ar.sub.2, carboxy, carbonyl, sulfonyl, formanilido, and thioformamido, wherein R.sub.1 and R.sub.2 are independently unsubstituted or substituted with one or more substituent (s); provided that when X is CH.sub.2 and Y is an unsubstituted or a monosubstituted CH.sub.2, R.sub.1 is C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.2, wherein R.sub.1 is unsubstituted or substituted with one or more substituent(s); orR.sub.1 and R.sub.2 are taken together, with the nitrogen atom to which they are attached, to form a 5-7 membered heterocyclic ring, wherein said heterocyclic ring optionally contains one or more additional heteroatom(s) independently selected from the group consisting of N, O, and S, and said heterocyclic ring is unsubstituted or substituted with one or more substituent(s);R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are independently unsubstituted or substituted with one or more substituent(s) and selected from the group consisting of hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, and Ar.sub.3 ; andAr.sub.1, Ar.sub.2, and Ar.sub.3 are independently a carbocyclic or heterocyclic moiety, which is unsubstituted or substituted with one or more substituent(s).