Patent ID: 8440816
Filing Date: 2013-05-14
Classification: A61K,C07K,C08G,C08L,C12N

Abstract:
1. A method of preparing a biologically active conjugate of the formula comprising: reacting a branched reactive polymer having the structure Y—(X)p-R(—X′-POLY) wherein: Y is a functional group; R is an aliphatic hydrocarbon having a length of at least three carbon atoms; X′ is —O—; X is a linker of 1 to 10 atoms in length; p is 0 or 1; q is 2 to about 10; L each POLY is a water soluble and non-peptidic polymer that terminates with a hydroxyl or methoxy group, and further wherein the branched polymer has a molecular weight of about 12,000 Da to about 100,000 Da.