Patent ID: 7883552
Filing Date: 2011-02-08
Classification: A23L,A61K,A61P,C01F,Y10S,Y10T

Abstract:
1. A method for preparing a high density, highly compactable granulation comprising the steps of: (a) mixing a composition comprising a powdered calcium carbonate having a median particle diameter of about 0.1 to about 20 μm, and additionally a material selected from the group consisting of dicalcium phosphate, calcium sulfate, ferrous sulfate, iron compounds, lactose, cellulose, micro-crystalline cellulose, kaolin, mannitol, maltodextrin, sodium chloride, starch, sugar, talc, silica, and combinations thereof, with water in a high shear mixer; and (b) drying the composition in a horizontal fluidized bed oven; thereby providing a high density, highly compactable granulation having a tap density between about 0.9 and about 2.0 g/cm 3 and that is free-flowing and has sufficient cohesive properties for compression into pharmaceutical or nutraceutical tablets.