Patent ID: 6040314
Filing Date: 2000-03-21
Classification: A61P,C07C,C07D

Abstract:
A method of treatment or prophylaxis of diseases or conditions in which inhibition of NOS is beneficial which comprises administering to a person in need thereof a therapeutically effective amount of a compound of formula (1) ##STR6## wherein D represents alkyl C1 to 6T represents a C.sub.3-5 saturated or unsaturated alkylene chain substituted by (CH.sub.2).sub.m --NXY, --O--(CH.sub.2).sub.2 --NH-- substituted by --(CH.sub.2).sub.m --NXY; or --U--(CH.sub.2).sub.a --N(X)--(CH.sub.2).sub.b --;U represents NH, O or CH.sub.2 ;a and b, which may be the same or different, represent an integer 0 to 3, provided that a+b is in the range 1 to 3;X and Y, which may be the same or different, represent hydrogen, alkyl C1 to 6, or a group --(CH.sub.2).sub.n Q,or NXY together represents piperidinyl, pyrrolidinyl, morpholinyl, or tetrahydroisoquinolinyl;Q represents phenyl optionally substituted by alkyl C1 to 6, alkoxy C1 to 6, trifluoromethyl, halogen, nitro or cyano;m and n independently represents an integer 0 to 5;or a pharmaceutically acceptable salt thereof.