Patent ID: 8148422
Filing Date: 2012-04-03
Classification: A61P,C07C,C07D

Abstract:
1. A compound of Formula (I) wherein Y is R R R R R R or, R or, R (i) azetidin-1-yl optionally substituted with 3-fluoro, 3,3-difluoro, 3-hydroxy, hydroxymethyl, 3-trifluoromethyl, one to two C (ii) piperazin-1-yl wherein the piperazinyl nitrogen is substituted with R (iii) pyrrolidin-1-yl optionally substituted with 3-fluoro, 3,3-difluoro, 3-hydroxy, 2-trifluoromethyl, 3-trifluoromethyl, hydroxymethyl, one to two C (iv) piperidin-1-yl optionally substituted with 3,3-difluoro, 4,4-difluoro, 3- or 4-hydroxy, 3- or 4-trifluoromethyl, hydroxymethyl, one to two C (v) [1,4]diazepan-1-yl wherein the 4-nitrogen of the diazepan-1-yl is substituted with R (vi) [1,4]diazepan-5-yl wherein the 1-nitrogen of the [1,4]diazepan-5-yl is substituted with R (vii) a heterocyclyl that is benzofused to form a benzofused heterocyclyl selected from the group consisting of  wherein (a), (b), and (c) are optionally substituted on the heterocyclyl portion of said ring with one to two methyl substituents;  or, the heterocyclyl portion of a benzofused heterocyclyl (a), (b), or (c) is unsubstituted, and the benzo portion of said ring is optionally substituted with one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, iodo, methyl, trifluoromethyl, cyano, C R and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof wherein the compound of Formula (I) does not include solvates.