Patent ID: 8722351
Filing Date: 2014-05-13
Classification: C07K,G01N

Abstract:
1. A method to determine the presence and concentration of anti-SELENBP1 autoantibodies in a biological sample from an individual suspected of having ovarian cancer, comprises: (a) contacting the biological sample with antigen SELENBP1 or a fragment thereof in conditions where naturally occurring autoantibodies form antigen antibody complexes with the antigen provided; (b) determining the presence and concentration of anti-SELENBP1 autoantibodies in the biological sample by analysis of the complexes; and (c) comparing the presence and concentration of anti-SELENBP1 autoantibodies determined in (b) with values in biological samples from subjects without ovarian cancer; and (d) inferring that ovarian cancer is present in the individual, if anti-SELENBP1 autoantibodies are present in a concentration that is higher than the concentration in the subjects without ovarian cancer.