Patent ID: 8728528
Filing Date: 2014-05-20
Classification: A01N,A61K,B01J,C11D

Abstract:
1. A process for preparing low residual solvent level microparticles, comprising: (a) providing a dispersed phase comprising a polymer excipient in a weight amount of a dispersed phase solvent, W (b) combining the dispersed phase with a continuous phase processing medium to form an emulsion wherein the dispersed phase is a discontinuous phase in the continuous phase; (c) combining the emulsion formed in (b) with a weight amount of an extraction phase solvent, W (d) isolating the microparticles; wherein the amount of residual dispersed phase solvent present in the isolated microparticles is less than or equal to about 3 wt %, and is less than the amount of residual dispersed phase solvent present in microparticles produced by said process in the absence of PEG; the total amount of extraction phase solvent is W wherein W S is the solubility of the dispersed phase solvent in water; and ER is the Extraction Ratio, wherein ER is less than or equal to about 10.