Patent ID: 7476402
Filing Date: 2009-01-13
Classification: A61K,A61P

Abstract:
1. A therapeutic pharmaceutical composition comprising a mixture including: (a) at least one opioid analgesic agonistic to the mu-receptor selected from the group consisting of: alfentanil, buprenorphine, carfentanil, codeine, dezocine, diacetylmorphine, dihydrocodeine, dihydromorphine, fentanyl, hydrocodone, hydromorphone, β-hydroxy-3-methylfentanyl, levo-α-acetylmethadol, lofentanil, methadone, morphine, oxycodone, oxymorphone, propoxyphene, remifentanil, sufentanil, tilidine, and tramadol; (b) at least one opioid analgesic agonistic to the kappa-receptor selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine; (c) gel-forming polyethylene oxide at about 3 to about 40 percent by weight; (d) at least one disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and (e) sodium lauryl sulfate at about 1 to 10 percent by weight.