Patent ID: 6274737
Filing Date: 2001-08-14
Classification: C07C,C07D,C07F

Abstract:
A compound of Formula (I): ##STR20##wherein:R.sub.1 is --X(CH.sub.2).sub.n Ar', dihydrobenzofuranyl, benzodioxanyl,cyclohexyl or C.sub.1-4 alkyl, wherein Ar' is a moiety of formula (a) or (b); ##STR21##wherein A is C.dbd.O, or (C(R.sub.6).sub.2)m; andB is --CH.sub.2 -- or --O--;R.sub.2 is a moiety of fornula (a) or (b);P.sub.1 is --X(CH.sub.2).sub.n Rg;P.sub.2 is hydrogen or C.sub.1-4 alkyl,R.sub.6 is independently hydrogen or C.sub.1-10 alkyl;R.sub.7 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-10 alkenyl or C.sub.2-8 alkynyl, all of which may be unsubstituted or substituted by one or morc OH, N(R.sub.6).sub.2, CO.sub.2 R.sub.12, Br, Cl, F, I, or XC.sub.1-5 alkyl; or R.sub.7 is (CH.sub.2).sub.n Ar;R.sub.8 is hydrogen, R.sub.11, CO.sub.2 R.sub.7, CO.sub.2 C(R.sub.11).sub.2 O(CO)XR.sub.7, PO.sub.3 (R.sub.7).sub.2, SO.sub.2 NR.sub.7 R.sub.11, N.sub.7 SO.sub.2 R.sub.11,CONR.sub.7 SO.sub.2 R.sub.11, SO.sub.3 R.sub.7, SO.sub.2 RR.sub.7, P(O)(OR.sub.7)R.sub.7, CN, --CO.sub.2 (CH.sub.2).sub.m C(O)N(R.sub.6).sub.2, C(R.sub.11).sub.2 N(R.sub.7).sub.2, C(O)N(R.sub.6).sub.2, tetrazole or OR.sub.6 ;R.sub.9 is a bond, C.sub.1-10 alkylene, C.sub.2-10 alkenylene, C.sub.1-10 alkylidene, C.sub.2-10 aldkynylene, all of which may be linear or branched, or R.sub.9 is phenylene, all of which may be unsubstituted or substituted by one or more OH, N(R.sub.6).sub.2, COOH or halogen;R.sub.10 is hydrogen;R.sub.11 is hydrogen, Ar, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, all of whiich may be unsubstituted or substituted by one or more OH, CH.sub.2 OH, N(R.sub.6).sub.2 'Br, Cl, I, or F;R.sub.12 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-7 alkynyl;R.sub.13 is divalent Ar, C.sub.1-10 alkylene, C.sub.1-10 alkylidene, C.sub.2-10 alkenylene, C.sub.2-10 alkynylene, all of which may be unsubstltuted or substituted by one or two OH, CH.sub.2 OH, N(R.sub.6).sub.2 Br, Cl, I, or F;X is (CH.sub.2).sub.n or O;Y is CH.sub.3 or X(CH.sub.2).sub.n Ar;Ar is naplthyl, indolyl, pyridyl, thienyl, oxazolidinyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyll imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, prolyl, or pyrimidyl; all of which may be unsubstituted or substituted by one or two OH, C.sub.1-5 alkoxy, I, Br, F, Cl, --OC.sub.1-4 alkylphenyl, R.sub.13 CO.sub.2 R.sub.7, C.sub.1-4 alkyl, --N(R).sub.6).sub.2, --NH(CO)CH.sub.3, --X(CH.sub.2).sub.n Rg, --X--R.sub.9 --Y, pyridyl, phenyl or S(O).sub.q Cl.sub.5 alkyl, provided that when R.sub.13, R.sub.8 pr Y are Ar, the Ar is not substituted by another Ar which is further substituted by an yet another Ar;Z.sub.1, Z.sub.2 and Z.sub.3 are independently hydrogen, OH, C.sub.1-8 alkoxy, S(O)qC.sub.1-8 alkyl, N(R.sub.6).sub.2, Br, F, I, Cl, NHCOR.sub.6, --X--R.sub.9 --Y, --X(CH.sub.2).sub.n R.sub.8 ; or Z.sub.1 and Z.sub.2 together may be --O--A--O-- on contiguous carbons;q is zero, onc or two;n is an integer from 0 to six;m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof; provided thatwhen Z.sub.1, Z.sub.2, or Z.sub.3 is X(CH.sub.2).sub.n R.sup.8, n is not 0 when X is oxygcn and R.sup.8 is OR.sub.6 or CO.sub.2 H; andP.sub.1 is not CO.sub.2 H, C(R.sub.6).sub.2 COOH or tetrazole wien P.sub.2 is hydrogen and Ar is pyridyl.