Patent ID: 9096570
Filing Date: 2015-08-04
Classification: C07D

Abstract:
1. A process for manufacturing a compound of formula (I), wherein Q Z is hydrogen or halogen; Z Y and Y R R comprising (i) reacting a compound of formula (II), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from the group consisting of 1,2-dichloroethane, 1,2-dichlorobenzene, 1,3-dichlorobenzene, and 1,4-dichlorobenzene, and wherein the pH-value of the aqueous phase is from 3 to <8, to obtain a compound of formula (III), and (ii) reacting the compound of formula (III) with a tertiary amine base Q in a solvent at a temperature range of 0° C. to 100° C. to obtain a compound of formula (I).