Patent ID: 6419953
Filing Date: 2002-07-16
Classification: A61K

Abstract:
A controller release tablet dosage form comprising:a) a hydrophilic matrix formed from a uniform admixture of: i) about 50 weight percent to about 55 weight percent of an active ingredient selected from the group consisting of valproic sodium acid, a pharmaceutically acceptable salt or ester if valproic acid, divalproex sodium, and valpromide; ii) about 20 weight percent to about 40 weight percent of hydroxypropyl methylcellulose, and iii) about 5 weight percent to about 15 weight percent of lactose; b) from about 4 weight percent to about 6 weight percent of microcrystalline cellulose; c) and from about 1 about 5 weight percent of silicon dioxide; all weight percentages are based upon the total weight of the tablet dosage form.