Patent ID: 6239297
Filing Date: 2001-05-29
Classification: C07C

Abstract:
Derivatives of sphingosine analogues represented by the general formula (I) described below. ##STR31##In the formula, R.sup.1 and R.sup.2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 carbon atoms, or acyl groups having 2-5 carbon atoms. R.sup.3 and R.sup.4, which are the same or different each other, are hydrogen or hydroxyl groups; or R.sup.3 and R.sup.4 make up a covalent bond. X.sup.1 is --(CH.sub.2).sub.n --CO--NH--CH(R.sup.5)--R.sup.6 or --(CH.sub.2).sub.m --O--CO--CH(R.sup.7)--R.sup.8. The n means an integral number ranging from 0 to 3. R.sup.5 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.6 is --CH.sub.2 OH, --COOH, --CONH.sub.2, or --CO--NH--CH(R.sup.9)--R.sup.10. R.sup.9 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.10 is --CH.sub.2 OH, --COOH, --CONH.sub.2, or --CO--NH--CH(R.sup.11)--R.sup.12. R.sup.11 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.12 is --CH.sub.2 OH, --COOH, or --CONH.sub.2. The m means an integral number ranging from 1 to 3. R.sup.7 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.8 is --CH.sub.2 OH, --NH.sub.2, or --NH--CO--CH(R.sup.13)--R.sup.14. R.sup.13 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.14 is --CH.sub.2 O, --NH.sub.2, or --NH--CO--CH(R.sup.15)R.sup.16. R.sup.15 is hydrogen, a hydroxyl group, or an alkyl group having 1-4 carbon atoms which may have a hydroxyl group. R.sup.16 is --NH.sub.2 or --CH.sub.2 OH.The compound which has hydrogen as R.sup.1, R.sup.2, and R.sup.3, a hydroxyl group as R.sup.4, and --CH.sub.2 --CO--NH--CH(R.sup.5)--R.sup.6 as X.sup.1, in which R.sup.5 is --CH(CH.sub.3).sub.2 or --CH--(CH.sub.3)C.sub.2 H.sub.5, and R.sup.6 is --CO--NH--CH(R.sup.9)--R.sup.10 in which R.sup.9 and R.sup.10 are --CH.sub.2 OH, is excluded.