Patent ID: 6500985
Filing Date: 2002-12-31
Classification: C07B,C07C,C07D

Abstract:
A process for producing an &agr;-aminohalomethylketone represented by formula (3) wherein A represents an optionally substituted alkyl group having 1 to 10 carbon atoms, an optionally substituted aryl group having 6 to 15 carbon atoms, an optionally substituted aralkyl group having 7 to 20 carbon atoms, or a group in which heteroatom is contained in these carbon skeletons, and X represents a halogen atom or its salt, which comprises reacting an N-protected-&agr;-amino acid ester represented by formula (1) wherein R1 and R2, independently from each other, represent an optionally substituted aryl group or lower alkyl group, or a hydrogen atom, R3represents an optionally substituted lower alkyl group, aralkyl group or aryl group, and A is as defined above, provided R1 and R2 may together form a ring structure with a halomethyllithium, and then treating this with an acid.