Patent ID: 7470687
Filing Date: 2008-12-30
Classification: A61P,C07D

Abstract:
1. A method of preparing a pharmaceutical composition, which comprises combining a pharmaceutically acceptable excipient with at least one compound of the formula I: in which: R R R B is an aromatic isocyclic or heterocyclic radical, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by R X is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH R R R R Y is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH A, A′ are each, independently of one another, aryl, Het, alkyl having 1-10 carbon atoms or alkenyl having 2-8 carbon atoms, in which one, two or three CH A and A′ together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH A″, A′″are each, independently of one another, a single bond, alkylene having 1-10 carbon atoms, alkenylene having 2-8 carbon atoms or cycloalkylene having 3-7 carbon atoms, in which one, two or three CH A″, and A′″ together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH aryl is phenyl, naphthyl, fluorenyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, R R R Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 2 N, O and/or S atoms, which is unsubstituted or monosubstituted or disubstituted by carbonyl oxygen, Hal, R Hal is F, Cl, Br or I, and m is 0, 1 or 2;