Patent ID: 6060512
Filing Date: 2000-05-09
Classification: A61K,A61P,A61Q,B24D,Y10S

Abstract:
A method of treating skin changes associated with intrinsic and/or extrinsic aging comprising topically applying to an area of skin containing said skin change associated with aging a hydroxymonocarboxylic acid having the following formula:R.sub.1 (CR.sub.2 OH).sub.m (CH.sub.2).sub.n COOHwhereinR.sub.1, R.sub.2 are selected from the group consisting of hydrogen, alkyl, aralkyl and aryl, where said alkyl, aralkyl or aryl can be saturated or unsaturated, straight, branched or cyclic, and each has from 1-25 carbon atoms;where the hydrogen atoms of R.sub.1 and R.sub.2 and (CH.sub.2) may be substituted by a component selected from the group consisting of F, Cl, Br, I, S, lower alkyl, lower alkoxy, wherein the alkyl and alkoxy groups have from 1-9 carbon atoms and can be saturated or unsaturated;m is an integer of from 1 to 9; andn is zero or an integer of from 1 to 23;existing in isomeric or non-isomeric form, free acid or lactone form,or a topically effective salt thereof,wherein said hydroxymonocarboxylic acid is applied in an amount and for a period of time sufficient to treat said skin change associated with intrinsic or extrinsic aging, andwherein said skin change associated with intrinsic or extrinsic aging is selected from the group consisting of pigmented age spots, melasmas, lentigines, solar lentigines, pigmented skin spots, blemished skin, hyperpigmented skin, pigmented lesions, mottling, excessive deposition of abnormal elastic materials (elastosis), and thickening of the skin.