Patent ID: 6797256
Filing Date: 2004-09-28
Classification: A61K,Y10T

Abstract:
A method for determining pyrimidine metabolizing activity in an individual subject, comprising:(i) administering to the subject uracil or thymine wherein at least one of C, O, and N is labeled with a non-radioactive isotope, and measuring a non-radioactive isotope-labeled metabolite; (ii) administering to the subject dihydrouracil or dihydrothymine wherein at least one of C, O, and N is labeled with anon-radioactive isotope, and measuring a non-radioactive isotope-labeled metabolite; (iii) administering to the subject &bgr;-ureidopropionic acid or &bgr;-ureidoisobutyric acid wherein at least one of C, O, and N is labeled with a non-radioactive isotope, and measuring a non-radioactive isotope-labeled metabolite; and (iv) determining pyrimidine metabolizing activity in the subject from the measurements of Steps (i), (ii), and (iii).