Patent ID: 6827938
Filing Date: 2004-12-07
Classification: A61K,A61P

Abstract:
A method of enhancing proliferation or survival of kidney tubule epithelial cells or epithelial cell precursors in a mammal in need thereof, comprising administering to the mammal a composition comprising a therapeutically effective amount of a zvegf4 protein, in combination with a pharmaceutically acceptable delivery vehicle, wherein the zvegf4 protein is a disulfide-bonded dimer of two polypeptide chains, each of said chains consisting of residues x-y of SEQ ID NO:2, inclusive, wherein the protein is optionally glycosylated, and wherein:x is selected from the group consisting of 16, 17, 18, 19, 20, 21, 22, 24, 25, 35, 52, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 246, 250, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, and 263; and y is selected from the group consisting of 365, 366, 367, 368, 369, and 370.