Patent ID: 6558912
Filing Date: 2003-05-06
Classification: A61K,A61P,C07K

Abstract:
A method for identifying a compound that modulates apoptosis, said method comprising:(a) contacting (i) a p75NTR polypeptide; (ii) an NRAGE polypeptide comprising at least 90% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2, said NRAGE polypeptide capable of binding said p75NTR polypeptide; and (iii) a candidate compound; and (b) monitoring the level of binding of said NRAGE polypeptide to said p75NTR polypeptide, wherein a change in said level of binding in the presence of said candidate compound, relative to a level of binding of said NRAGE polypeptide to said p75NTR polypeptide in the absence of said candidate compound, identifies said candidate compound as a compound that modulates apoptosis.