Patent ID: 7747395
Filing Date: 2010-06-29
Classification: C07K,C12N,C12Y,G01N

Abstract:
1. A method for the design and identification of a potential binding compound for human peptide deformylase (HsPDF) comprising the steps of: (a) generating, on a computer, a three-dimensional structure of HsPDF having the structural coordinates of Tables 1 and/or 2; (b) identifying amino acid residues forming an HsPDF active site from the three-dimensional structure of HsPDF from step (a) in order to generate a three-dimensional model of the HsPDF active site, wherein the HsPDF active site comprises amino acids (c) designing and/or selecting a compound that potentially binds to the HsPDF active site using the three-dimensional model of the HsPDF active site; and (d) synthesizing and/or choosing the potential binding compound.