Patent ID: 7388118
Filing Date: 2008-06-17
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula I: or a pharmaceutically acceptable salt thereof, where R N is (I) R (C) —(CH″R′″) where R  pyridinyl, pyrimidinyl, quinolinyl, benzothienyl, indolyl, indolinyl, pryidazinyl, pyrazinyl, isoindolyl, isoquinolyl, quinazolinyl, quinoxalinyl, phthalazinyl, imidazolyl, isoxazolyl, pyrazolyl, oxazolyl, thiazolyl, indolizinyl, indazolyl, benzisothiazolyl, benzimidazolyl, benzofuranyl, furanyl, thienyl, pyrrolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, oxazolopyridinyl, imidazopyridinyl, isothiazolyl, naphthyridinyl, cinnolinyl, carbazolyl, beta-carbolinyl, isochromanyl, chromanyl, tetrahydroisoquinolinyl, isoindolinyl, isobenzotetrahydrofuranyl, isobenzotetrahydrothienyl, isobenzothienyl, benzoxazolyl, pyridopyridinyl, benzotetrahydrofuranyl, benzotetrahydrothienyl, purinyl, benzodioxolyl, triazinyl, henoxazinyl, phenothiazinyl, pteridinyl, benzothiazolyl, imidazothiazolyl, dihydrobenzisoxazinyl, benzisoxazinyl, benzoxazinyl, dihydrobenzisothiazinyl, benzopyranyl, benzothiopyranyl, coumarinyl, isocoumarinyl, chromonyl, chromanonyl, tetrahydroquinolinyl, dihydroquinolinyl, dihydroquinolinonyl, dihydroisoquinolinonyl, dihydrocoumarinyl, dihydroisocoumarinyl, isoindolinonyl, benzodioxanyl, benzoxazolinonyl, pyridinyl-N-oxide, pyrrolyl N-oxide, pyrimidinyl N-oxide, pyridazinyl N-oxide, pyrazinyl N-oxide, quinolinyl N-oxide, indolyl N-oxide, indolinyl N-oxide, isoquinolyl N-oxide, quinazolinyl N-oxide, quinoxalinyl N-oxide, phthalazinyl N-oxide, imidazolyl N-oxide, isoxazolyl N-oxide, oxazolyl N-oxide, thiazolyl N-oxide, indolizinyl N-oxide, indazolyl N-oxide, benzothiazolyl N-oxide, benzimidazolyl N-oxide, pyrrolyl N-oxide, oxadiazolyl N-oxide, thiadiazolyl N-oxide, triazolyl N-oxide, tetrazolyl N-oxide, benzothiopyranyl S-oxide, benzothiopyranyl S,S-dioxide, imidazopyrazolyl, quinazolinonyl, pyrazopyridyl, benzooxadiazolyl, dihydropyrimidinonyl, and dihydrobenzfuranonyl, (II) —CO—(C (III) —CO—(C (IV) —CO—(C (V) —CO—CH(—(CH  R (VI) —CO—(C where R 1 is (VI) —(CH where R 20 is H, CH 3 , or C 2 -C 6 alkyl or alkenyl either of which may be optionally substituted with one, two or three substituents independently selected from the group consisting of C 1 -C 3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —CON, —CF 3 , C 1 -C 3 alkoxy, —NR 1-a R 1-b ; where n is 0 or 1; where R c is —O—R A , —X—R A , —NH—NHR A , —NR 20 —NHR A , —NH—NR 20 R A or —NR 20 —NR 20 R A , wherein X is —S—, —S(═O), —SO 2 —, —NH—, —N(R 20 )—, —N(R A ), —NH—N(R A )—, or —NR 20 —N(R A )—; where R A is (I) —C  R (III) —(CH  —H,  C  C  —(CH  C  C or  R (IV) —(CH  R  where the R (V) —(CH (VI) —(CH (VII) —(CH (VIII) —(CH (IX) —(CH (X) —(CH (XI) —(CH (XII) —(CH (XIII) —(CH  R (XIV) —(CH (XV) —[C(R and where (XVI) —CH(R (XVII) —CH(R (XVIII) —CH(R (XIX)-cyclopentyl, -cyclohexyl, or -cycloheptyl ring fused to R (XX) C (XXI) C (XXI) —(CH  R (XXII) —(CH (XXIII) —CH(R (XXIV) —CH(CH (XXV) —(C (XXVII) —CH (XXVIII) —H, and (XXIX) —(CH provided that if X is NH, then R A is not —CH 2 —CH(OCH 2 CH 3 ) 2 ; and if R C is —OR A , then R A is not —(C 1 -C 6 alkyl)—OH.