Patent ID: 6919190
Filing Date: 2005-07-19
Classification: C12N,C12P

Abstract:
1. A method of producing an amino acid by fermentation which comprises: (a) cultivating a host microorganism belonging to the genus Escherichia, Corynebacterium or Brevibacterium in a suitable medium; and (b) isolating from the culture medium an amino acid, wherein said host microorganism (a) is transformed with a DNA fragment comprising a gene encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein the nucleotides of said gene encoding the amino acid sequence Met-Ala-Ser-Ile-Asp-Ala-Gln-Leu-Arg are deleted, wherein said host microorganism (a) expresses said gene, and wherein said polypeptide does not require acetyl coenzyme A for activation and is desensitized to feedback inhibition by aspartic acid.