Patent ID: 8003789
Filing Date: 2011-08-23
Classification: A61K,A61P

Abstract:
1. A compound having the formula a N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein -b 1 =b 2 -C(R 2a )=b 3 -b 4 = represents a bivalent radical of formula q is 0, 1, 2; 3; or 4; R R each R wherein each A independently is N, CH or CR L is C L is —X—R Q represents hydrogen, C R R Y represents hydroxy, halo, C aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C Het is an aliphatic or aromatic heterocyclic radical; said aliphatic heterocyclic radical is selected from pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl and tetrahydrothienyl wherein each of said aliphatic heterocyclic radical may optionally be substituted with an oxo group; and said aromatic heterocyclic radical is selected from pyrrolyl, furanyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl wherein each of said aromatic heterocyclic radical may optionally be substituted with hydroxy.