Patent ID: 6337406
Filing Date: 2002-01-08
Classification: C07B,C07C,C07F

Abstract:
A compound of the formula or their corresponding enantiomers whereinA) R is C1-C8 alkyl, C1-C8 alkyl aryl, aryl C1-C8 alkyl, aryl, each of which may be substituted with carboxylic acid, alkoxy, hydroxy, alkylthio, thiol, dialkylamino, diphenylphosphino or chiral oxazoline; and B) the ring component represents a protected diol, a crown ether linkage, â€”Oâ€”C1-C8 alkyl-Oâ€” wherein the alkyl group is linked to a polymer, â€”Oâ€”(CH2CH2)nâ€”Oâ€” wherein n is an integer ranging from 1 to 8 and the methylene groups are optionally substituted by C1-C8 alkyl, or Oâ€”Wâ€”O, where W is BR9, POR9, PO (OR9), SO2, CO, or Si(R9)2;where R9 is C1-C8 alkyl, aryl, C1-C8 alkyl aryl, or aryl C1-C8 alkyl, alkoxy, hydroxy, alkylthio, thio, alkylamino, dialkylamino; and C) R2 is either R, H, phenyl or a symmetrical bidentate structure having the formula â€ƒwherein isi) â€”(CH2)nâ€” where n is an integer from 1 to 8; or ii) â€”(CH2)nX(CH2)mâ€” where n and m are the same or different integers from 1 to 8, and X is O, S, NR4, PR4, AsR4, SbR4, divalent aryl, divalent fused aryl, divalent 5-membered heterocyclic ring, or divalent fused heterocyclic ring, where R4 is C1-C8 alkyl, aryl, substituted aryl, or substituted alkyl; or iii) 1,2-divalent phenyl, 2,2â€²-divalent 1,1â€²biphenyl, 2,2â€²-divalent, 1,1â€²binapthyl, or ferrocene, each of which may be substituted independently with C1-C8 alkyl or aryl, F, Cl, Br, I, COOR5, SO3R5, PO3R52, OR5, SR5, NR52, PR52, AsR52, SbR52, nitro, vinyl, substituted vinyl, alkynyl wherein R5 is H, C1-C8 alkyl, substituted C1-C8 alkyl, C1-C8 fluoroalkyl, C1-C8 perfluoroalkyl, aryl or substituted aryl; and wherein Z is a compound selected from the group of compounds having the following formulas and their corresponding enantiomers: