Patent ID: 6947845
Filing Date: 2005-09-20
Classification: A61K,A61P,C07D,C07K,G01N,Y02A

Abstract:
1. A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of: (a) providing a molecular model comprising one or more target regions selected from the group consisting of at least a portion of (i) an anisomycin binding site, (ii) an azithromycin binding site, (iii) a blasticidin binding site, (iv) a carbomycin A binding site, (v) an erythromycin binding site, (vi) a linezolid binding site, (vii) a sparsomycin binding site, (viii) a spiramycin binding site, (ix) a tylosin binding site, and (x) a virginiamycin M binding site, wherein the molecular model is made; (1) from the atomic co-ordinates for the (2) from atomic co-ordinates derived by molecular modeling using the atomic coordinates for the (b) using the molecular model to identify a candidate molecule that can bind to the molecular model; and (c) producing the candidate molecule identified in step (b).