Patent ID: 6326406
Filing Date: 2001-12-04
Classification: A61K,A61P

Abstract:
A process for the preparation of a clear, aqueous injectable pharmaceutical formulation of propofol, comprising the following steps:(a) adding a lecithin to an aqueous solution of a pharmaceutically acceptable bile acid salt, the aqueous solution having a pH from 4.5 to 6.5;(b) heating the aqueous dispersion obtained in step (a) to a temperature from 35.degree. C. to 85.degree. C. to dissolve the lecithin;(c) dissolving any foam which is obtained in step (b);(d) heating the dispersion obtained in step (c) to a temperature from 35.degree. C. to 85.degree. C.;(e) adding propofol to the dispersion obtained in step (d); and(f) cooling the dispersion obtained in step (e) and adding water to obtain the clear, aqueous formulation in the desired final volume.