Patent ID: 6265579
Filing Date: 2001-07-24
Classification: C07D

Abstract:
A process for preparing a piperazine-substituted aliphatic carboxylic acid having the formula ##STR8##wherein R is phenyl and R' is 4-cholorophenyl, said process comprising (a) treating a solution comprising a compound of the formula ##STR9##wherein R and R' are as defined above and an aliphatic ester of the formulaX--CH.sub.2 --CO(O)R""wherein X is a leaving group and R"" is tert-butyl, with a base in the presence of an effective amount of a phase-transfer catalyst, for a time and at a temperature sufficient to form said piperazine-substituted aliphatic carboxylate of the formula ##STR10##wherein R, R' and R"" are as defined above and (b) hydrolyzing said piperazine-substituted aliphatic carboxylate with acid to form said piperazine-substituted aliphatic carboxylic acid.