Patent ID: 6703385
Filing Date: 2004-03-09
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, and heterocyclic groups, (b) the groups represented by (a) each substituted independently with at least one group selected from non-interfering substituents, or (c) â€”(CH2)mâ€”R5 wherein m is an integer from 1 to 6, and R5 is a group selected from the groups (a) and (b); R2 is a group represented by the formula: wherein R18 and R19 are independently a hydrogen atom, C1 to C3 alkyl or a halogen; G1 and G2 are independently an oxygen atom or a sulfur atom; and G3 is â€”NH2 or â€”NHNH2; Q1 is a nitrogen atom or Câ€”R4; one of R3 and R4 is â€”(L2)-(acidic group) wherein L2 is represented by the formula: wherein M is â€”CH2â€”, â€”Oâ€”, â€”N(R15)â€”, or â€”Sâ€”; R13 and R14 are independently a hydrogen atom, C1 to C10 alkyl, aryl, aralkyl, carboxy, or a halogen, and R15 is C1 to C6 alkyl; and the acidic group is represented by the formula: wherein R16 is hydrogen atom, a metal, or C1 to C10 alkyl; R17 is independently a hydrogen atom or C1 to C10 alkyl; R35 is C1-C5 alkyl or phenyl; h is an integer from 1 to 8; and the other is a hydrogen atom, provided that when Q1 is nitrogen, R3 is â€”(L2)-(acidic group) wherein L2 and acidic group are as defined above; R21 and R22 are independently a hydrogen atom, C1 to C6 alkyl, aryl, a halogen or aralkyl; X is â€”CR23R24â€”, O, or S, wherein R23 and R24 are independently a hydrogen atom or C1 to C6 alkyl; Y is a bond or â€”CR25R26â€”, wherein R25 and R26 are independently a hydrogen atom or C1 to C6 alkyl; Z is CHRA, CRA, N, or NRB, wherein RA is a hydrogen atom, alkyloxycarbonyl, or carboxy; RB is a hydrogen atom or acyl; a broken line ( - - - ) represents the presence or absence of a bond, its prodrug, pharmaceutically acceptable salt, or solvate thereof.