Patent ID: 6133275
Filing Date: 2000-10-17
Classification: C07D

Abstract:
A compound of formula (I) ##STR15## wherein R.sub.1 represents 1 or more optional substituents independently selected from the group consisting ofC.sub.1-8 alkyl;C.sub.2-8 alkenyl;C.sub.2-8 alkynyl;alkoxyalkyl, wherein the alkyl and alkylene groups are independently C.sub.1-8 ;C.sub.1-8 alkoxy;C.sub.1-8 alkoxycarbonyl;hydroxy;C.sub.1-8 hydroxyalkyl;carboxy;O-protected carboxy;C.sub.1-8 carboxyalkyl;O-protected C.sub.1-8 carboxyalkyl;halo;amino;N-protected amino;C.sub.1-8 aminoalkyl; andC.sub.1-8 N-protected aminoalkyl;L is C.sub.2-8 alkylene; andR.sub.3 is selected from the group consisting of ##STR16## wherein, for (1), (3), (5) and (6), R.sub.4 and R.sub.5 together form a ring which is fused to its adjacent ring and is selected from the group consisting of(a) a five-membered carbocyclic ring and(b) a five-membered ring having four carbon atoms and one heteroatom selected from the group consisting ofnitrogen,oxygen, andsulfur;(c) a five-membered ring having three carbon atoms and two heteroatoms independently selected from the group consisting ofnitrogen,oxygen, andsulfur;(d) a six-membered carbocyclic ring;(e) a six-membered ring having five carbon atoms and one heteroatom selected from the group consisting ofnitrogen,oxygen, andsulfur;(f) a six-membered ring having four carbon atoms and two heteroatoms selected from the group consisting ofnitrogen,oxygen, andsulfur;(g) a six-membered ring having three carbon atoms and three heteroatoms selected from the group consisting ofnitrogen,oxygen, andsulfur;wherein the five-membered rings formed by R.sub.4 and R.sub.5 together with the ring to which they are fused have 1 or 2 double bonds, and wherein the six-membered rings formed by R.sub.4 and R.sub.5 together with the ring to which they are fused have 1, 2 or 3 double bonds, and wherein the rings formed by R.sub.4 and R.sub.5 together are optionally substituted with one or two substituents independently selected from the group consisting ofC.sub.1-8 alkyl;C.sub.1-8 alkoxy;cyano;nitro;carboxy;C.sub.1-8 alkoxycarbonyl;halo;C.sub.3-8 cycloalkyl;aryl; andheterocycle,A is selected from the group consisting of--O--;--S(O).sub.t --, wherein t is zero to two, and--NR.sub.6 --, andX is --NR.sub.6 --; andor a pharmaceutically acceptable salt, ester or prodrug thereof.