Patent ID: 7780949
Filing Date: 2010-08-24
Classification: A61K,G01N

Abstract:
1. A method for reducing an accumulation of collagen associated with chronic kidney disease, renal fibrosis or renal sclerosis comprising: providing a human subject having an accumulation of collagen associated with chronic kidney disease, renal fibrosis or renal sclerosis; measuring a CCN3 level and/or a CCN2 level in the subject prior to the step of administering a full-length nephroblastoma overexpressed product or protein (CCN3) to the subject; administering to the human subject a full-length nephroblastoma overexpressed gene product or protein (CCN3) to reduce accumulation of collagen in the subject; and measuring the CCN3 level and/or a CCN2 level in the subject after the step of administering and confirming the CCN3 level is higher in the subject than before the administering step or confirming the CCN2 level is lower in the subject than before the administering step to verify a reduction in the accumulation of collagen in the subject.