Patent ID: 9039782
Filing Date: 2015-05-26
Classification: A61F,A61K,A61L

Abstract:
1. A biocompatible composite scaffolding system capable of providing structural support for engineered bone tissue comprising: a first biodegradable matrix comprising a synthetic polymer and a naturally derived collagen matrix, wherein the first matrix has a porosity greater than about 50%; and comprises about 25% to about 75% synthetic polymer; a population of cells selected from the group consisting of cartilage-forming cells, bone-forming cells and combinations thereof seeded onto the first matrix; a second matrix comprising a flexible, collagen-containing matrix; and a population of muscle progenitor cells seeded onto the second matrix; wherein the seeded second matrix is preconditioned to induce muscle fiber orientation; wherein the first matrix and the second matrix are joined thereby forming a biocompatible composite scaffolding system.