Patent ID: 8975267
Filing Date: 2015-03-10
Classification: A61K,A61P,C07C,C07D,C12N

Abstract:
1. A compound of formula (I): wherein R1 is hydrogen, halogen or an optionally substituted group selected from amino, straight or branched C R2 is a group selected from —NHR″ and —N(OR′″)R″ wherein R″ and R′″ are, each independently, hydrogen or an optionally substituted group selected from straight or branched C R3 is hydrogen or optionally substituted group selected from straight or branched C R4 is hydrogen or an optionally substituted group selected from straight or branched C X is a group selected from —NR′—, —O— and —S—, wherein R′ is hydrogen or an optionally substituted group selected from straight or branched C A is a group selected from —(CH or a pharmaceutically acceptable salt thereof, with the proviso that the following compounds are excluded: 2-amino-9-methyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline-7-carboxamide, 2-amino-8-phenyl-9H-pyrrolo[3,2-h]quinazoline-7-carboxamide, 2-amino-9-methyl-8-phenyl-9H-pyrrolo[3,2-h]quinazoline-7-carboxamide and 2-amino-9-methyl-8-phenyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline-7-carboxamide.