Patent ID: 6096337
Filing Date: 2000-08-01
Classification: A61K

Abstract:
A method of producing a free-flowing and compressible liquid/powder admixture of a liquid medication, which involves converting the liquid medication into a liquisolid system, comprising the steps of:(a) selecting a weight of the liquid medication to be included in a single liquisolid system possessing a dosage of active ingredient;(b) selecting a carrier material and a coating material to be included in the liquisolid system;(c) admixing the liquid medication with a quantity of carrier material to make a wet mixture; and(d) blending the resulting wet mixture with the coating material to produce a nonadherent, free-flowing and compressible liquid/powder admixture, the amounts of liquid medication, carrier material and coating material being selected to optimize flow and compressibility according to values predetermined by liquisolid flowability and liquisolid compressibility tests.