Patent ID: 8993721
Filing Date: 2015-03-31
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A composition for detecting apoptotic cells comprising: (i) an isolated polypeptide consisting of the sequence (I) Cys-X1-Val-Ala-Pro-X2; and (ii) a labeling agent bound to the polypeptide of (i) selected from the group consisting of a coloring enzyme, a radioactive isotope, and a fluorescer, wherein X1 is an amino acid with polar uncharged side chain and X2 is an amino acid with positive charged side chain, and wherein the coloring enzyme is peroxidase or alkaline phosphatase; the radioactive isotope is selected from the group consisting of 18F, 124I, 125I, 32P, and 35P; and the fluorescer is selected from the group consisting of Fluorescein isothiocyanate (FITC), Rhodamine isothiocyanate (RITC), Green Fluorescent Protein (GFP), Enhanced Green Fluorescent Protein (EGFP), Red Fluorescent Protein (RFP),