Patent ID: 6100376
Filing Date: 2000-08-08
Classification: A61K,A61P,C07K

Abstract:
An insulin derivative having an isoelectric point between 5 and 8.5, or a physiologically tolerated salt thereof, of the formula II ##STR5## in which: R.sup.1 at position B1 denotes H or H-Phe,R.sup.2 at position A21 denotes a genetically encodable L-amino acid selected from the group consisting of Gly, Ala, Val, Leu, Ile, Pro, Phe, Trp, Met, Ser, Thr, Tyr, Asp, and Glu,R.sup.30 represents the residue of a neutral genetically encodable L-amino acid selected from the group consisting of Tyr, Gly, Phe, and Thr,R.sup.31 represents 1, 2, or 3 neutral or basic .alpha.-amino acids, whose terminal carboxyl group can be free or in the form of an amide functionality;X represents His at position B10; andthe sequences A1 to A20 and B2 to B29 in Formula II correspond to a mammalian insulin.