Patent ID: 9110078
Filing Date: 2015-08-18
Classification: G01N,G16B

Abstract:
1. A method for detecting a liver disease in a subject suspected of having the liver pathology comprising: obtaining biological fluid from the subject; separating anti-gal IgG from said biological fluid using a separation agent; contacting said separated anti-gal IgG from said biological fluid with a fucose-binding lectin, IgG, and allowing said lectin to bind to said anti-gal IgG; quantifiably detecting lectin bound to said anti-gal IgG to obtain a detected bound lectin value; comparing the detected bound lectin value with a reference value for lectin binding on said anti-gal IgG from a comparable biological fluid of subjects without said liver disease, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver disease, wherein a detected bound lectin value that deviates from said reference value to a statistically significant degree is indicative of the presence of said liver disease, or, comparing the detected bound lectin value with a reference value for lectin binding on said anti-gal IgG from a comparable biological fluid of subjects in which said liver disease is known to be present, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver disease, wherein a detected bound lectin value that deviates from said reference value to a statistically significant degree is indicative of the absence of said liver disease.