Patent ID: 9150576
Filing Date: 2015-10-06
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method for preparing L-aspartate of a quinolone antimicrobial agent, comprising reacting the quinolone antimicrobial agent with L-aspartic acid in an inert organic solvent that comprises ethyl acetate, methanol, ethanol, isopropanol, acetone, acetonitrile, hexane, isopropyl ether, or water, wherein the quinolone antimicrobial agent comprises norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, or combinations thereof, provided that about 0.9 to about 2.5 equivalent weight of the L-aspartic acid is added to about 1 equivalent weight of the quinolone antimicrobial agent.