Patent ID: 7906118
Filing Date: 2011-03-15
Classification: A61K,A61P,B82Y,C07K,C12N

Abstract:
1. A cytokine-antibody DNL (dock and lock) complex comprising: a) a cytokine moiety attached to a DDD (dimerization and docking domain) moiety, wherein said DDD moiety has a peptide sequence from a dimerization and docking domain of protein kinase A and consisting of the amino acid sequence of SEQ ID NO: 10; and b) an antibody or antigen binding fragment thereof that binds to tumor associated antigen attached to an AD (anchor domain) moiety, wherein the AD moiety has a peptide sequence from an anchoring domain of an AKAP (A-kinase anchoring protein) and consisting of the amino acid sequence of SEQ ID NO: 11; wherein two copies of the DDD moieties form a dimer that binds to the AD moiety to form the complex.