Patent ID: 8461178
Filing Date: 2013-06-11
Classification: A61P,C07D

Abstract:
1. A naphthyridine derivative of the general formula I wherein R1 and R3 are independently hydrogen or NR7R8, wherein at least one of R1 and R3 is NR7R8 wherein R7 is hydrogen, R8 is —C(Y)NR9R10, Y is O or S, R9 is hydrogen and R10 can independently be (i) unsubstituted or substituted alkyl, (ii) unsubstituted or substituted cycloalkyl, (iii) unsubstituted or substituted heterocyclyl, (iv) unsubstituted or substituted aryl, (v) unsubstituted or substituted heteroaryl, R2 is (vi) hydrogen, (vii) unsubstituted or substituted alkyl, (viii) unsubstituted or substituted heterocyclyl, (ix) unsubstituted or substituted aryl, (x) unsubstituted or substituted heteroaryl, (xi) halogen, (xii) cyano, (xiii) hydroxyl, (xiv) alkoxy, (xv) amino, (xvi) carboxyl, alkoxycarbonyl, carboxyalkyl or alkoxycarbonylalkyl, (xvii) alkoxycarbonylamino, alkoxycarbonylaminoalkyl, and (xviii) NR7R8, wherein in R2 or R3 R7 is hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl may be optionally substituted, and R8 is —C(Y)NR9R10, where Y is O or S and R9 and R10 are independently of one another R5 is a unsubstituted or substituted heteroaryl, R4 and R6 are independently of one another: (i) hydrogen, (ii) unsubstituted or substituted alkyl, (iii) unsubstituted or substituted cycloalkyl, (iv) unsubstituted or substituted heterocyclyl, (v) unsubstituted or substituted aryl, (vi) unsubstituted or substituted heteroaryl, (vii) halogen, (viii) cyano, (ix) hydroxyl, (x) alkoxy, (xi) NR15R16, where R15 and R16 are, independently of each other, hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcyclyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl are optionally substituted, (xii) OR17, where R17 can be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl are optionally substituted, (xiii) SR18, where R18 can be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl are optionally substituted, their physiologically acceptable salts, hydrates, solvates, where the compounds of the general formula (I) and their salts, hydrates or solvates may be present in the form of their racemates, enantiomers and/or diastereomers, or in the form of mixtures of the enantiomers and/or diastereomers, in the form of the tautomers and their polymorphic forms.