Patent ID: 6040148
Filing Date: 2000-03-21
Classification: A61P,C07K,Y10S

Abstract:
A purified Corynebacterial stress protein having an apparent molecular weight of about 86 Kd, said stress protein having the following features:(1) being an antigen;(2) inducing in patients with Corynebacterium jeikeium septicemia on recovery antibody to a 52 Kd breakdown product of the stress protein;(3) inducing in patients with Corynebacterium jeikeium endocarditis antibody to a 52 Kd breakdown product of the stress protein;(4) being cross reactive with a mouse monoclonal antibody against a peptide antigen KVIRKNIVKKMIE (SEQ ID NO: 1); and(5) cross-reaction of the stress protein with said mouse monoclonal antibody is neutralized by peptide KVIRKNIVKKMIE (SEQ ID NO: 1).