Patent ID: 6664281
Filing Date: 2003-12-16
Classification: C07D

Abstract:
A compound of the formula (I) (wherein,A1 is C1-4 alkylene, A2 is C2-8 alkylene, C3-8 alkenylene or C3-8 alkynylene, E1 is â€”Oâ€” or â€”Sâ€”, E2 is â€”CH2â€”, â€”Oâ€”, or â€”S(O)mâ€”. m is 0, 1 or 2, each R1 in (R1)n independently, is hydrogen, C1-8 alkyl, halogen, C1-4 alkoxy, C1-4 alkythio, nitro, NR7R8 (in which R7 and R8 each independently, is C1-4 alkyl), cyano, trifluoromethyl, trifluoromethyloxy, carbocyclic ring or heterocyclic ring (in which carbocyclic ring and heterocyclic ring may be substituted with the group selected from C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl), R2 is hydrogen, C1-8 alkyl, halogen, C1-4 alkoxy, C1-4 alkythio, nitro, NR7R8 (in which R7 and R8 each independently, is C1-4 alkyl), cyano, trifluoromethyl or trifluoromethyloxy, R3 and R4 each independently, is hydrogen or C1-4 alkyl or R3 and R4 taken together with carbon atom to which is attached represents C3-7 cycloalkylene, R5 is â€”COOR9 (in which R9 is hydrogen or C1-4 alkyl) or heterocyclic ring which is equivalent to carboxylic acid, is oxazole, is phenyl or pyridinyl, and n is 1-3) a non-toxic salt thereof, or a hydrate thereof.