Patent ID: 7041830
Filing Date: 2006-05-09
Classification: C07D

Abstract:
1. A process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine having formula 1 which comprises oximation of a ketone of formula 10 with hydroxyl amine hydrochloride in an alcohol solvent at a temperature in the range of 60–80° C., removing the solvent by evaporation to obtain an oxime of formula 11 reducing the oxime of formula 11 with a reducing agent in an alcohol solvent at a temperature in the range of 40–60° C. for a time period in the range of 5–10 hrs, wherein the reducing agent is selected from the group consisting of sodium borohydride, LiAlH 4 , ammonium formate and sodium cyano borohydride, removing the solvent, extracting with ethyl acetate, washing with brine, removing the solvent by evaporation to obtain the (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine having formula 1.