Patent ID: 6316671
Filing Date: 2001-11-13
Classification: C07B,C07C

Abstract:
A method of splitting 1-amino-alkan-2-ol compounds of general formula: ##STR14##in which R represents linear, branched or cyclic alkyl groups, comprising from 1 up to about 25 carbon atoms, optionally having one or more double bonds, one or more hetero-atoms separated from the asymmetric carbon atom by at least one carbon link which do not destroy the aliphatic nature of R optionally substituted by one or more halogen atoms or lower alkoxy groupswherein the method comprises the steps of:a) dissolving a racemic form of a compound of formula (I) and one of enantiomers R or S of N-tosyl-leucine, in pure alcohol, in suitable proportions, and thenb) isolating the less soluble diastereoisomeric salt of the compound of formula (I) in crystallized form.