Patent ID: 6284923
Filing Date: 2001-09-04
Classification: A61P,C07C

Abstract:
A compound having the formula: ##STR48##or a pharmaceutically acceptable salt thereof, wherein:n is 2;R.sup.1 is a member selected from the group consisting of hydrogen, (C1-C6) alkyl, halogen, OCF.sub.3, CF.sub.3, NO.sub.2, CN, and CO.sub.2 --R.sup.8 ;R.sup.2 is a member selected from the group consisting of NO.sub.2, CN, CO.sub.2 --R.sup.8 and SO.sub.2 --R.sup.8 ;R.sup.3 is a member selected from the group consisting of halogen and OCF.sub.3 ;R.sup.4 is a member selected from the group consisting of hydrogen, halogen, OCF.sub.3, CF.sub.3, NO.sub.2, CN, and CO.sub.2 --R.sup.8 ;R.sup.5 is a member selected from the group consisting of hydrogen, (C1-C6) alkyl, halogen, OCF.sub.3, CF.sub.3, NO.sub.2, CN, and CO.sub.2 --R.sup.8 ;Y is N(R.sup.9);wherein R.sup.6 and R.sup.7 are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl and (C2-C6) heteroalkyl; R.sup.8 is selected from the group consisting of (C1-C6) alkyl and (C2-C6) heteroalkyl; and R.sup.9 is selected from the group consisting of hydrogen, substituted or unsubstituted (C1-C10)alkyl, substituted or unsubstituted (C3-C6)alkenyl, subsituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl; andAr is a substituted or unsubstituted phenyl group,wherein said substituents are independently selected from the group consisting of OH, halogen, NH.sub.2, NH(C1-C6)alkyl, N((C1-C6)alkyl).sub.2, (C1-C6) alkyl, and (C1-C6)alkoxy.