Patent ID: 7375127
Filing Date: 2008-05-20
Classification: A61P,C07D

Abstract:
1. A tetrahydrocarbazole compound of the formula (1) in which: X X R1 and R2 are independently of one another selected from the group consisting of —H, aryl, alkyl and arylalkyl radicals which are optionally substituted in the alkyl and/or aryl group by up to 3 substituents independently selected from the group consisting of -Hal, —CN and —O-alkyl, where R1 and R2 are in particular hydrogen, R3 is an alkyl, arylalkyl or heteroarylalkyl radical, which are optionally substituted by up to 3 substituents independently selected from the group consisting of -Hal, —CN, —CO—O—R12, —CO—NR12R12′, —OH, —O—R13, —O—CO—R13, —O—SO R4, R5, R6 and R7 are selected independently of one another from the group consisting of H, -Hal, —CN, —CONH R9 is a hydrogen atom, an alkyl, an aryl, a heteroaryl, an arylalkyl or a heteroarylalkyl radical; R10 is a hydrogen atom, or the radical —R11, —CO—R11, —CO—OR11, —CO—NHR11, —C(NH)—NHR11, —SO R11 is an alkyl, an aryl, a heteroaryl, an arylalkyl or a heteroarylalkyl radical, which are optionally substituted by one or more substituents independently selected from the group consisting of -Hal, —CN, -alkyl, —CF R8 is —C R12 and R12′ are independently of one another H, or an alkyl, arylalkyl, aryl, heteroarylalkyl, or heteroaryl radical; R13 is selected from an alkyl, arylalkyl, aryl, heteroarylalkyl, and heteroaryl radical, or is the group —(CH n is an integer from 1 to 10; and physiologically tolerated salts, derivatives or analogues of the compound of the formulae (1), where the salts are obtainable by neutralizing the bases with inorganic or organic acids or by neutralizing the acids with inorganic or organic bases, where the compound of the formula (1) and its salts, derivatives or analogues may be in the form of their racemates, in the form of the pure enantiomers and/or diastereomers or in the form of mixtures of these enantiomers and/or diastereomers, in the form of the tautomers, the solvates and hydrates thereof and the polymorphic forms thereof.