Patent ID: 8342737
Filing Date: 2013-01-01
Classification: B01F,C12M

Abstract:
1. A vibration mixer ( 1 ) for use in disposable bioreactors ( 4 , 4 ′) having a flexible wall, the vibration mixer comprising: a mixer stem ( 2 , 2 ′) which can be thrown into longitudinal movements by a drive ( 8 ), at least one mixing element ( 3 , 3 ′) mounted on the mixer stem ( 2 , 2 ′), the mixer stem ( 2 , 2 ′) being a tube with a free lumen ( 12 , 12 ′) defining at least one first duct ( 13 , 13 ′) having an inlet ( 14 ) external of the bioreactor ( 4 , 4 ′) for delivering gas into the free lumen ( 12 , 12 ′) and an outlet ( 16 ) toward a reactor interior ( 6 , 6 ′) for delivering the gas into the bioreactor ( 4 , 4 ′), and a tubular member or a hose ( 19 ) arranged in the free lumen ( 12 , 12 ′) of the mixer stem ( 2 , 2 ′) to define a second duct ( 20 ) in the mixer stem ( 2 , 2 ′), the second duct ( 20 ) having an inlet external of the bioreactor ( 4 , 4 ′) separated in a gas tight manner from the inlet ( 14 ) to the free lumen ( 12 , 12 ′) of the first duct ( 13 , 13 ′) and an outlet ( 21 ) in the bioreactor separated from the outlet ( 16 ) of the free lumen ( 12 , 12 ′) of the first duct ( 13 , 13 ′), the second duct ( 20 ) supplying media to the bioreactor ( 4 , 4 ′) or removing media from the bioreactor ( 4 , 4 ′).