Patent ID: 9119787
Filing Date: 2015-09-01
Classification: A61K,A61P

Abstract:
1. A method of treating a kidney disease comprising: administering into an artery directly servicing the kidney glomeruli of a patient in need thereof, microparticles comprising a bioactive agent, wherein the microparticles comprise a polymer selected from the group consisting of poly(lactide-co-glycolide-co-caprolactone), poly(lactide-bl-glycolide), poly(lactide-co-glycolide)-bl-polyethyleneglycol, poly(lactide-co-glycolide)-bl-polyethyleneglycol-bl-poly(lactide-co-glycolide), poly(lactide-co-glycolide-co-caprolactone), poly(lactide-co-glycolide-co-hydroxybutyric acid), poly(lactide-co-glycolide-co-trimethylene carbonate), poly(lactide-co-glycolide)-bl-polycaprolactone, poly(lactide-co-glycolide)-bl-poly(hydroxybutyric acid), poly(lactide-co-glycolide)-bl-poly(methylene carbonate), wherein: less than 10% of the microparticles degrade under physiological conditions to release a therapeutic amount of the bioactive agent within 1 week of administration and more than 90% of the microparticles degrade under physiological conditions to release a therapeutic amount of the bioactive agent within 12 months of administration, and wherein at least 80% of the microparticles become entrapped in the glomeruli of the kidney upon administration of the microparticles.