Patent ID: 6225292
Filing Date: 2001-05-01
Classification: A61K,A61P,C07H,C07K,C12N,C12Q,Y02A

Abstract:
A pharmaceutical composition for inhibiting immunostimulation by a immunostimulatory polynucleotide sequence (ISS) comprising a hexamer region consisting of at least one CpG nucleotide motif flanked by two 5' purines and two 3' pyrimidines, the composition comprising:(a) a nucleic acid molecule comprising a hexameric nucleotide sequence of the formula 5'-Purine--Purine-[Y]-[Z]-Pyrimidine-Pyrimidine-3' or 5'-Purine--Purine-[Y]-[Z]-poly(Pyrimidine)-3';where Y is any naturally occurring or synthetic nucleotide except cytosine and Z is any naturally occurring or synthetic nucleotide, wherein when Y is not guanosine or inosine, Z is guanosine or inosine; and(b) a pharmaceutically acceptable carrier.