Patent ID: 8278307
Filing Date: 2012-10-02
Classification: A61P,C07D

Abstract:
1. A compound of the Formula: or a tautomer or a pharmaceutically acceptable salt thereof, wherein: Ring T represents Ring A represents a 5- or 6-membered aryl or heteroaryl ring; Ring B represents a 5- or 6-membered aryl or heteroaryl ring; L each R each R 1 , R 2 and R 3 is independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocycle and heteroaryl, and in addition, NR 2 R 3 may be a 5- or 6-membered saturated, partially saturated or unsaturated ring, which is optionally substituted and contains 0-2 additional heteroatoms selected from N, O and S(O) r ; each R 4 is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclic and heteroaryl; R in which: (i) Ring C is a 5- or 6-membered heteroaryl or heterocyclic ring comprising carbon atoms and 1-3 heteroatoms independently selected from O, N and S(O) (ii) L (iii) Ring D is a 5- or 6-membered heterocyclic or heteroaryl ring comprising carbon atoms and 1-3 heteroatoms independently selected from O, N and S(O) each R each of the foregoing alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclic and heteroaryl moieties is optionally substituted; m is 0, 1, 2, 3 or 4; n is 0, 1, 2 or 3; p is 1, 2, 3, 4 or 5; r is 0, 1 or 2; x is 0, 1, 2 or 3; z is 1, 2, 3 or 4; each optional substituent for an unsaturated carbon atom of an aryl or heteroaryl moiety and for a carbon atom of an alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkynyl or non-aromatic heterocyclic group is selected from F, Cl, Br, I, —CN, —R 4 , —OR 2 , —S(O) r R 2 , —SO 2 NR 2 R 3 , —NR 2 R 3 , —(CO)YR 2 , —O(CO)YR 2 , —NR 2 (CO)YR 2 , —S(CO)YR 2 , —NR 2 C(═S)YR 2 , —OC(═S)YR 2 , —C(═S)YR 2 , —YC(═NR 3 )Y′R 2 , —COCOR 2 , —COMCOR 2 , —YP(═O)(YR 4 )(YR 4 ), —Si(R 2 ) 3 , —NO 2 , —NR 2 SO 2 R 2 and —NR 2 SO 2 NR 2 R 3 , where M is a 1-6 carbon alkyl group; each optional substituent for an alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkynyl or non-aromatic heterocyclic group alternatively is selected from ═O, ═S, ═NH, ═NNR 2 R 3 , ═NNHC(O)R 2 , ═NNHCO 2 R 2 , and ═NNHSO 2 R 2 ; and each optional substituent on a nitrogen is selected from R 4 , —NR 2 R 3 , —C(═O)R 2 , —C(═O)OR 2 , —C(═O)SR 2 , —C(═O)NR 2 R 3 , —C(═NR 2 )NR 2 R 3 , —C(═NR 2 )OR 2 , —C(═NR 2 )R 3 , —COCOR 2 , —COMCOR 2 , —CN, —SO 2 R 3 , S(O)R 3 , —P(═O)(YR 2 )(YR 2 ), —NR 2 SO 2 R 3 and —NR 2 SO 2 NR 2 R 3 .