Patent ID: 6770650
Filing Date: 2004-08-03
Classification: C07D

Abstract:
A compound having the Formula (I), wherein:R1 and R2 are, independently of each other, hydrogen or alkyl; m is 0 or 1; Ar is heteroaryl, and Ar1 is aryl or heteroaryl, with the proviso that Ar is not indazolyl and Ar1 is not imidazopyridine; F is alkylene, or a bond; each R is independently hydrogen or alkyl, or R together with either R3 or R4 and the atoms to which they are attached form a carbocycle or a heterocycle; R3 and R4 are, independently of each other, selected from: (i) hydrogen, branched alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclyalkyl, heteroalkyl, cyano, or â€”(alkylene)â€”C(O)â€”Z, where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy, provided that both R3 and R4 are not hydrogen; or (ii) R and R4 together with the carbon atom to which they are attached form a carbocycle or a heterocycle; E is â€”N(R6)C(O)N(R5)â€”, â€”N(R6)C(S)N(R5)â€”, or â€”C(&boxH;O)N(R5)â€”, wherein: R5, R6, and R9 are independently hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, heteroalkyl, or â€”(alkylene)â€”C(O)â€”Z, where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy; provided that when E is â€”C(&boxH;O)N(R5)â€”, â€”N(R6)C(O)N(R5)â€”, or â€”N(R6)C(S)N(R5)â€”, then m is 1; Q is an alkylene chain of between 1-6 carbon atoms inclusive; and individual isomers, mixture of isomers and pharmaceutically acceptable salts thereof.