Patent ID: 7780986
Filing Date: 2010-08-24
Classification: A61K,A61P,C07D,Y10S

Abstract:
1. A process for the production of an orally administrable antibiotic matrix preparation comprising a mixture of a salt with the free base of a quinolone active compound at a salt-to-free base weight ratio of from 1:10 to 10:1, wherein the preparation releases 80% of the active compound both in 0.1 N hydrochloric acid and in acetate buffer at pH 4.5 in the USP XXIV paddle test at 50 revolutions per minute/37° C. in the course of 1 to 4 hours, and wherein the preparation is a combination preparation comprising a rapid-release (IR) part and a delayed release (CR) part, according to which one part of the active compound is mixed with disintegrant, granulated and mixed with glidant and lubricant (IR part), and another part of the active compound is mixed with acid and a gel-forming polymer, granulated and mixed with glidant and lubricant (CR part), and IR part and CR part are tabletted to give combination tablets and the resulting tablets are coated.