Patent ID: 7429591
Filing Date: 2008-09-30
Classification: A61P,C07D

Abstract:
1. A method for treating an autoimmune disease in a subject, said method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound of formula (I) below: wherein: R R each of R R R R R R R R R each of R R R each of R each of R n is 1; G represents C each of R L is amino, mono- or di-C X is nitrogen or R Y is nitrogen or R Z is nitrogen or R with the following provisons: R R R Ar represents a monocyclic or bicyclic aryl or heteroaryl ring, optionally substituted with between 1 and 3 substituents selected from halogen, C R R each of R 17 and R 53 is C 1-5 alkyl, phenyl, or C 1-5 heterocyclyl; each of R 54 and R 55 is independently hydrogen, C 1-5 alkyl, C 2-5 alkenyl, phenyl, benzyl, or C 1-5 heterocyclyl; W represents SO R R R R R R wherein each of the above hydrocarbyl or heterocarbyl groups, unless otherwise indicated, and in addition to any specified substituents, is optionally and independently substituted with between 1 and 3 substituents selected from methyl, halomethyl, hydroxymethyl, halo, hydroxy, amino, nitro, cyano, C or a pharmaceutically acceptable salt, ester, or amide thereof; and wherein the autoimmune disease is selected from lupos, rheumatritis,and asthma.