Patent ID: 6677376
Filing Date: 2004-01-13
Classification: A61K,A61P,C07C

Abstract:
A complex comprising a compound of Formula II and a cyclophilin, wherein Formula II is where R4 and R5 may independently be â€”Nâ€”SO2â€”R, â€”SO2â€”NRR, â€”Oâ€”R, â€”COâ€”Nâ€”R, â€”Nâ€”COâ€”R, â€”COâ€”R, wherein each of R may independently be hydrogen, Q, or C1-C6 branched or straight alkyl or alkenyl chain, which may be substituted in one or more positions by C3-C8 cycloalkyl or cycloalkenyl, hydroxyl, or carbonyl oxygen, and where in said alkyl or alkenyl chain one or more carbon atoms are either optionally substituted with Q, or optionally replaced by O, S, SO, SO2, N, or NH; where Q, which is optionally saturated, partially saturated, or aromatic, is a mono-, bi-, or tricyclic, carbo- or heterocyclic ring, wherein each ring may be optionally substituted in one to five positions with halo, hydroxyl, nitro, trifluoromethyl, acetyl, aminocarbonyl, methylsulfonyl, oxo, cyano, carboxy, C1-C6 straight or branched chain alkyl or alkenyl, C1-C4 alkoxy, C1-C4 alkenyloxy, phenoxy, benzyloxy, amino, or a combination thereof, and wherein the individual ring sizes are 5-6 members, and wherein each heterocyclic ring contains 1-6 heteroatoms selected from the group consisting of O, N, S, or a combination thereof.