Patent ID: 6521646
Filing Date: 2003-02-18
Classification: A61P,C07C,C07D

Abstract:
Compounds of the formula I in whichR1 is OR4, NHR4 or NAâ€³2, R2 is H, Hal, NO2, NHR4, NAâ€³2, OR4, SO3R4, SO2R4 or SR4, R3 is NH2, H2Nâ€”C(&boxH;NH) or H2Nâ€”(C&boxH;NH)â€”NH, where the primary amino groups are optionally protected with an amino protective group or R5â€”NHâ€”, R4 is H, A, Ar, or Aralk, R5 is a mono- or binuclear heterocycle having 1 to 4 N, O and/or S atoms, which can be unsubstituted or mono-, di- or trisubstituted by Hal, Aâ€³, â€”COâ€”A, OAâ€², CN, COOAâ€², CONH2, NO2, &boxH;NH or &boxH;O, A is alkyl having 1-15 C atoms or cycloalkyl having 3-15 C atoms, which is unsubstituted or mono-, di- or trisubstituted by R6, and in which one, two or three methylene groups can be replaced by N, O and/or S, R6 is Hal, NO2, NHAâ€², NAâ€³2, OAâ€², phenoxy, COâ€”Aâ€², SO3Aâ€², CN, NHCOAâ€², COOAâ€², CONAâ€²2, or SO2Aâ€², Aâ€² is H or alkyl having 1-6 C atoms, Aâ€³ is alkyl having 1-6 C atoms, Ar is a mono- or binuclear aromatic ring system, which is unsubstituted or mono-, di- or trisubstituted by alkyl having 1-6 C atoms and/or an R6-substituted mono- or binuclear aromatic ring system having 0, 1, 2, 3 or 4 N, O and/or S atoms, Aralk is a aralkylene having 7-14 C atoms, which is unsubstituted or mono-, di- or trisubstituted by R6 and in which one, two or three methylene groups can be replaced by N, O and/or S, Hal is F, Cl, Br, or I, m, n in each case independently of one another are 0, 1, 2, 3, or 4, and their physiologically acceptable salts and solvates.