Patent ID: 7498339
Filing Date: 2009-03-03
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein X and Y are selected from the combinations of: X is CH X is C═O, and Y is O, X is O, and Y is CH and X is O, and Y is C═O; R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy or C 1-6 -haloalkoxy; R 5 and R 5′ are each independently hydrogen or methyl; R 6 and R 6′ are each independently hydrogen or methyl; R 7 is hydrogen, C 1-6 -alkyl, —C(O)O—C 1-6 -alkyl, or —C(O)O—C 2-6 -alkenyl; R 8 , R 8′ , R 9 , R 9′ , and R 10 are each independently selected from hydrogen, halogen, C C C C hydroxy; R 11 is hydrogen, C —(CR A is halo, nitro, hydroxy, cyano, ═O, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -hydroxyalkyl, C 1-6 -cyanoalkyl, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —(CH 2 ) x —S(O) 0-2 C 1-6 -alkyl, —(C 1-6 -alkylene)-O—C 1-6 -alkyl, —(C 1-6 -alkylene)-O—C 1-6 -haloalkyl, —(CH 2 ) x —NR a R b , —(CH 2 ) x —C(O)NR a R b , —(CH 2 ) x —S(O) 2 NR a R b , —(CH 2 ) x —R c , —(CH 2 ) x —O—R d , —(CH 2 ) x —S(O) 0-2 —R d , —(CH 2 ) x —NR a R d , —(CH 2 ) x —C(O)—NR a R d , —(CH 2 ) x —C(O)R e , —(CH 2 ) x —NR a S(O) 2 R e , or —(CH 2 ) x —NR a (CH 2 ) x C(O)R e , wherein x is from 0 to 4; R R R R or one of R 8 or R 8′ together with R 11 and the atoms to which they are bound form a 5-membered carbocycle, optionally anellated with benzo, wherein the benzo is optionally substituted with one, two or three substituents selected from halo, C or a pharmaceutically acceptable salt thereof.