Patent ID: 8283489
Filing Date: 2012-10-09
Classification: C07B,C07C

Abstract:
1. A process for producing an optically active α-fluorocarboxylate represented by formula [2] wherein R 1 represents a C 1-6 alkyl group, R 2 represents a C 1-4 alkyl group, and * represents an asymmetric carbon, the process comprising reacting an optically active α-hydroxycarboxylate represented by formula [1] wherein R 1 , R 2 and * are defined as above, with sulfuryl fluoride (SO 2 F 2 ), trifluoromethanesulfonyl fluoride (CF 3 SO 2 F) or nonafluorobutanesulfonyl fluoride (C 4 F 9 SO 2 F), in the presence of organic base and in the absence of reaction solvent, wherein stereochemistry of the asymmetric carbon in formula [1] is inverted by the reaction.