Patent ID: 6063370
Filing Date: 2000-05-16
Classification: A61K,A61P,Y10S

Abstract:
A macromolecular drug complex comprising:(a) a drug having at least one quaternary ammonium nitrogen atom; and(b) a polymer having a plurality of acid moieties and a weight average molecular weight of about 2,000 to about 12,000, wherein the acid moieties of the polymer are selected from the group consisting of carboxyl, phosphate, phosphonate, sulfate, sulfonate, phenolic, and mixtures thereof, for noncovalent complexing with the quaternary ammonium nitrogen atom of the drug,wherein the complex is water-insoluble at an acidic pH and has a weight ratio of the drug to the polymer in the complex is about 10:90 to about 90:10, and wherein the formation of the macromolecular drug complex is confirmed by the CF-MALLS technique.