Patent ID: 8895543
Filing Date: 2014-11-25
Classification: A61P,C07D

Abstract:
1. A method for treating a condition selected from the group consisting of leukemia, carcinoma of the breast, lymphosarcoma, ovarian cancer, squamous cell cancer of the lung, and Hodgkin's disease in mammals comprising: administering to a mammal a therapeutically effective amount of the compound of Formula (I) as follows: where: R 1 is: alkyl; alkenyl; alkynyl; aryl; 3-methylpyrazol-1-yl; pyridyl; thienyl; thiazolyl; piperidinyl; morpholinyl; pyrrolidinyl; azetidinyl; Cl; Br; F; CN; C(O)NR C(O)NHR C(O)NH C(O)NHNH C(O)NR C(O)NR C(O)NR C(O)NHNHR C(O)NHNR C(O)NHOH; SO SO SO SO SO SO CO SR SSR SO SO B(OR CF SH; SO NH NHR NHSO NR NHCOR NR NR R 2 =alkyl or CH(O); R 3 =hydrogen, alkyl, or C(O)R 5 ; R 4 =hydrogen or C(O)R 5 ; R 5 , R 6 and R 7 each are independently alkyl, alkenyl, alkynyl, or aryl; R 8 =hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, acyl, or thioalkyl; R 9 ═OH and R 10 ═H or R 9 and R 10 together form a bridging double bond; R 5 and R 6 can form a ring or R 6 and R 7 can form a ring; X═OR 5 , NR 5 R 6 , NHNH 2 , NHNHC(O)R 5 , OH, NHR 5 , NH 2 , or NHNHC(O)H; R 4 and X can be linked together with intervening atoms to form a ring; R 1 and R 8 can be linked together; or a pharmaceutically acceptable salt thereof, wherein the alkyl and alkenyl groups can be branched or straight, with the proviso, that when R 8 ═H, R 9 ═OH, and R 10 ═H, then R 1 ≠Br and the proviso that if R 1 is an unsubstituted aryl, then R 2 ≠CH 3 .