Patent ID: 7390811
Filing Date: 2008-06-24
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I′) an addition salt, or stereochemically isomeric form thereof, wherein -a wherein each hydrogen atom in (a-2) may optionally be replaced by halo, C wherein Z is O, CH—C(═O)—NR Q is a radical of formula wherein Alk is C 1-6 alkanediyl; Y X 1 is NR 4 , S, S(═O), S(═O) 2 , O, CH 2 , C(═O), C(═CH 2 ), CH(OH), CH(CH 3 ), CH(OCH 3 ), CH(SCH 3 ), CH(N 5a R 5b ), CH 2 —NR 4 or NR 4 —CH 2 ; X 2 is a direct bond, CH 2 , C(═O), NR 4 , C 1-4 alkyl-NR 4 , NR 4 —C 1-4 alkyl; t is 2, 3, 4 or 5; u is 1, 2, 3, 4 or 5; v is 2 or 3; and whereby each hydrogen atom in Alk and the carbocycles and the heterocycles defined in radicals (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8) may optionally be replaced by R G is a direct bond or C R each n independently is 1, 2, 3 or 4; R R R R R R aryl is phenyl or phenyl substituted with 1 or more substituents selected from halo, hydroxy, C provided that when G is methylene, and R