Patent ID: 6417219
Filing Date: 2002-07-09
Classification: A61P,C07D

Abstract:
A compound having a structure according to Formula (I) whereinA is alkyl, heteroalkyl, aryl or heteroaryl, substituted or unsubstituted; R1 is NHOR2, where R2 is hydrogen or alkyl; W is one or more of hydrogen; lower alkyl; or an alkylene bridge that forms a ring in addition to the ring depicted in Formula (I); Y is independently one or more of hydroxy, SR3, SOR4, SO2R8, alkoxy, or amino, wherein amino is of formula NR6R7, wherein R6 and R7 are independently chosen from hydrogen, alkyl, heteroalkyl, heteroaryl, aryl, OR3, SO2RS, COR9, CSR10, and PO(R11)2; R3 is hydrogen, alkyl, aryl, or heteroaryl; R4 is alkyl, aryl, or heteroaryl; each R8 is independently alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylarnino, diarylarnino or alkylarylamino; R9 is hydrogen, alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino or alkylarylamino; R10 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino or alkylarylamino; R11 is alkyl, aryl, heteroaryl, or heteroalkyl; Z is hydrogen; hydroxy; alkyl; or an alkylene or heteroalkylene bridge that forms a ring in addition to the ring depicted in Formula (I); and n is 1; provided that (i) when any one or more of R3, R4, R8, R9, R10, R11, W, Y or Z is itself, or together with another moiety forms, a heterocyclic moiety, that heterocyclic moiety is fiuran, and (ii) when W or Z is an alkylene or heteroalkylene bridge that forms a second ring filsed to the ring depicted in Formula (I), that second ring does not include the ring carbon atom depicted in Formula (I) that is bonded to C(&boxH;O)â€”R1; or an optical isomer, diastereomer or enantiomer of Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.