Patent ID: 7226906
Filing Date: 2007-06-05
Classification: A61K,C07K

Abstract:
1. A cyclosporin analog having the Formula I or a pharmaceutically acceptable salt thereof, wherein: residue A has the formula R V, W, Y and T are independently selected from H, F, Br, Cl, alkyl, Z X is selected from and D is O, S, —CH R R R R R A Z is alkylene having from 1 to 4 carbons, or alkenylene or alkynylene each having from 2 to 4 carbons, wherein said alkylene, alkenylene, and alkynylene are optionally substituted with one or more groups independently selected from alkyl, OH, O-alkyl, NR R R residue B is -αABu-, -Val-, -Thr-, or NVa-; residue U is -(D)Ala-, (-D)Ser-, —[O-(2-hydroxyethyl)(D)Ser]-, —[O-acyl(D)Ser] or —[O-(2-acyloxyethyl)(D)Ser]-; and n is 0, 1, 2, 3, or 4.