Patent ID: 6353007
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound of Formula I wherein:R1 is in the 4-, 5-, 6-, or 7-position of the indole, and R1 is H; CF3; halogen; CN; branched or unbranched C1-8 alkyl; branched or unbranched C2-8 alkenyl; C3-8 cycloalkyl optionally substituted with OH, CN, or methoxy; C1-8 alkoxy; C1-4 alkyloxyalkyl; C1-8 alkylthio; C1-4 alkylthioalkyl; C1-8 dialkylamino; C1-4 dialkylaminoalkyl; CO2R4; or aryl or heterocyclyl connected to the indole in any position that makes a stable bond and wherein the aryl thereof is optionally substituted with halogen, C1-4 alkyl, C2-4 alkenyl, CN, Me2N, CO2Me, OMe, aryl, heterocyclyl, or R4; R2 is H; CF3; halogen; CN; branched or unbranched C1-8 alkyl; branched or unbranched C2-8 alkenyl; C3-8 cycloalkyl optionally substituted with OH, CN, or methoxy; C1-8 alkoxy; C1-4 alkyloxyalkyl; C1-8 alkylthio; C1-4 alkylthioalkyl; C1-8 dialkylamino; C1-4 dialkylaminoalkyl; CO2R4; or aryl connected to the indole in any position that makes a stable bond and wherein the aryl thereof is optionally substituted with halogen, C1-4 alkyl, C2-4 alkenyl, CN, Me2N, CO2Me, OMe, or aryl; L is â€”NHC(O)â€”, â€”NHC(O)Oâ€”, â€”NHC(O)C(O)â€”, â€”NHC(S)â€”, â€”NHC(O)NHâ€”, or â€”NHC(S)NHâ€”; R3 is pyridyl optionally substituted with one or more of the following: halogen, CN, NO2, SO2NH2, or R6, wherein R6 is phenyl, heterocyclyl, C3-6 cycloalkyl, C1-6 alkyl, C2-6 alkenyl, C1-6 alkyloxyalkyl, C1-6 alkylthioalkyl, C1-6 alkyl-sulfinylalkyl, C1-6 alkylsulfonylalkyl, or C2-6 alkynyl, and R6 is optionally substituted with halogen, OH, alkyloxy, CN, â€”COO-lower alkyl, â€”CONH-lower alkyl, â€”CON(lower alkyl)2, dialkylamino, phenyl, or heterocyclyl; and R4 is C1-4 alkyl or C2-4 alkenyl optionally substituted with carbocyclyl, or a pharmaceutically acceptable derivative thereof.