Patent ID: 9108954
Filing Date: 2015-08-18
Classification: A61P,C07D

Abstract:
1. A method for synthesizing Dasatinib, comprising the following steps: the compound of Formula I: reacts with the compound of Formula II: to yield the compound of Formula III: wherein, R R R R the compound of Formula III reacts with 1-(2-hydroxyethyl)piperazine: to yield the compound of Formula VII: the compound of Formula VII is hydrolyzed to yield the compound of Formula VIII: the compound of Formula VIII is converted by the action of chlorination agents to be the compound of Formula IX: the compound of Formula IX reacts with 2-chloro-6-methylaniline to yield Dasatinib; alternatively, the compound of Formula VIII reacts with 2-chloro-6-methylaniline in the presence of an amidation condensing agent to yield Dasatinib; wherein, R4 in Formula VII is defined as the one in Formula III.