Patent ID: 7282590
Filing Date: 2007-10-16
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound having the formula Y-A-Z, wherein: A is a phenyl group; wherein A is unsubstituted or substituted with 1 to 4 substituents selected from lower alkyl, hydroxy-(lower alkyl), amino-(lower alkyl), N-(lower alkyl)amino-(lower alkyl), N,N-di(lower alkyl)amino-(lower alkyl), hydroxylamino, O-(lower alkoxy)amino, fluoro, chloro, bromo, nitro, hydroxyl, lower alkoxy, amino, N-(lower alkyl)amino, or N,N-di(lower alkyl)amino; Y and Z are substituents at adjacent positions on A; Y represents: wherein X is O or S; Z represents: R G is a hydrogen, a lower alkyl, a metal ion or a quaternary ion; J is omega-hydroxycarbonyl-(lower alkyl), omega-(lower alkoxy)carbonyl-(lower alkyl), or omega-(X-G)-carbonyl-(lower alkyl), wherein X-G represents a carbonyl activating group selected from the group consisting of hydroxybenzotriazole-1-oxy, succinimide-N-oxy, p-nitrophenoxy and pentafluorophenyloxy, wherein lower means having 1-6 carbon atoms.