Patent ID: 6252061
Filing Date: 2001-06-26
Classification: C07D,C07F,C07H

Abstract:
A method for synthesizing 2-halo-6-aminopurine derivatives, comprising the steps of:admixing a nonpolar aprotic organic solvent with a polar aprotic organic solvent to produce a solvent mixture;dissolving in said solvent mixture a compound having the formula ##STR24##wherein R is selected from the group consisting of hydrogen, C.sub.1 to C.sub.20 linear and branched chain alkyl, C.sub.3-20 cycloalkyl, C.sub.1-20 alkoxyalkyl, C.sub.1-20 alkylamino, C.sub.1-20 ether, C.sub.1-20 thioether, C.sub.1-20 haloalkyl, a C.sub.6-20 monocyclic aryl group, a C.sub.6-20 multicyclic aryl group, a heterocyclic aryl group having from 1 to 20 carbon atoms and 1 to 10 heteroatoms, sugar moieties selected from the group consisting of .beta.-D-ribofuranosyl, deoxy-.beta.-D-furanosyl, xylofuranosyl, arabinofuranosyl, wherein the hydroxyl groups of said sugar moieties are unprotected; 2'-, 3'-, and 2', 3'-substituted analogs of .beta.-D-ribofuranosyl, deoxy-.beta.-D-furanosyl, xylofuranosyl, or arabinofuranosyl; andreacting said compound in said solvent mixture with an organic nitrite and a metal halide, wherein said metal halide is a Lewis acid, to produce a reaction product.