Patent ID: 8921545
Filing Date: 2014-12-30
Classification: A61K,A61P,C07D

Abstract:
1. A method of preparing a spiro indolinone compound represented by the following Structural Formula: or a salt thereof, comprising the step of reacting an indolinone compound represented by the following Structural Formula: with a base and an indazole compound represented by the following Structural Formula: wherein: each of R C (C each R i) hydrogen; ii) a C iii) a C each R R R R each R i) hydrogen; ii) a C iii) a C each R each R each R N(R each R each R independently is hydrogen, C N(R) each R′ independently is C each Ar X P P each p is 1, 2 or 3; each q is 2, 3, 4 or 5; n is 1, 2 or 3; and m is 1 or 2.