Patent ID: 6048865
Filing Date: 2000-04-11
Classification: A61K

Abstract:
A compound of the following formula: ##STR3## wherein: R is hydrogen, alkyl, substituted alkyl, or aryl;R.sup.1 is heteroaryl-NR--, heteroaryl-, or aryl-,R.sup.2 is hydrogen, alkyl, substituted alkyl, or aryl-NH--C(X)--,R.sup.3 and R.sup.4 are independently selected from the group consisting of hydroxy, hydrogen, halo, azido, alkyl, alkoxy, carboxy, cyano, nitro, aryl, and amino,wherein the heteroaryl groups are selected from the group consisting of furyl, indolizinyl, benzothienyl, isoxazolyl, thiadiazolyl, and pyridinyl;wherein the aryl groups may optionally be substituted with from 1 to 5 substituents selected from the group consisting of hydroxy, acyl, alkyl, alkoxy, alkenyl, alkynyl, substituted alkyl, substituted alkoxy, substituted alkenyl, substituted alkynyl, amino, substituted amino, acyloxy, acylamino, aryl, aryloxy, azido, carboxyl, carboxylalkyl, cyano, halo, nitro, heteroaryl, heteroaryloxy, thioalkoxy, substituted thioalkoxy, thioaryloxy, thioheteroaryloxy, --SO-alkyl, --SO-substituted alkyl, --SO-aryl, --SO-heteroaryl, --SO.sub.2 -alkyl, --SO.sub.2 -substituted alkyl, --SO.sub.2 -aryl, --SO.sub.2 -heteroaryl and trihalomethyl,wherein the heteroaryl groups may optionally be substituted with from 1 to 5 substituents selected from the group consisting of hydroxy, acyl, alkyl, alkoxy, alkenyl, alkynyl, substituted alkyl, substituted alkoxy, substituted alkenyl, substituted alkynyl, amino, substituted amino, acyloxy, acylamino, aryl, aryloxy, azido, carboxyl, carboxylalkyl, cyano, halo, nitro, heteroaryl, heteroaryloxy, thioalkoxy, substituted thioalkoxy, thioaryloxy, thioheteroaryloxy, --SO-alkyl, --SO-substituted alkyl, --SO-aryl, --SO-heteroaryl, --SO.sub.2 -alkyl, --SO.sub.2 -substituted alkyl, --SO.sub.2 -aryl, --SO.sub.2 -heteroaryl, and trihalomethyl, andX is O.