Patent ID: 7553973
Filing Date: 2009-06-30
Classification: A61P,C07D

Abstract:
1. A compound of structural Formula Ia or a pharmaceutically acceptable salt or ester thereof wherein: “A” is selected from the group consisting of (a) phenyl, (b) —CH and wherein A is optionally mono- or di-substituted with a substituent independently selected at each occurrence from the group consisting of (i) —F (ii) —Cl, (iii) —C 1-3 alkyl optionally substituted with one or more of halo, (iv) —OC 1-3 alkyl optionally substituted with one or more of halo, (v) —OC 3-6 cycloalkyl, (vi) —CH 2 OH, (vii) —COOR 1 , (viii) —CN and (ix) —NR 10 R 11 ; X is selected from —O— and —S—; Y is selected from —NR R R R R or R or R or R R R R R R R R Z is selected from the group consisting of phenyl, —CH and wherein Z is optionally mono- or di-subsituted with a substituent independently selected at each occurrence from the group consisting of (i) —F, (ii) —Cl, (iii) —C 1-3 alkyl optionally substituted with one or more of halo, (iv) —OC 1-3 alkyl optionally substituted with one or more of halo, (v) —OC 3-6 cycloalkyl, (vi) —CH 2 OH, (vii) —COOR 1 , (viii) —CN and (ix) —NR 10 R 11 .