Patent ID: 6291452
Filing Date: 2001-09-18
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound represented by the formula: ##STR24##whereinR.sup.1 is(5) aryl(lower)alkyl which may have one or more suitable substituent(s), or ##STR25##whereinA is lower alkylene andR.sup.5 is(a) lower alkyl,(b) C.sub.3 -C.sub.8 cycloalkyl,(c) adamantyl, or(d) aryl which may have one or more suitable substituent(s),R.sup.2 is(1) lower alkyl,(3) lower alkoxy(lower)alkyl,(5) N,N-di(lower)alkylamino(lower)alkyl,(6) lower alkylpiperazinyl(lower)alkyl,(7) lower alkylthio(lower)alkyl,(8) hydroxy(lower)alkyl,(9) protected hydroxy(lower)alkyl,(10) azabicyclo[3.2.2]nonyl(lower)alkyl,(12) cyano,(13) lower alkanoyl,(14) carboxy(lower)alkenyl, or(15) protected carboxy(lower)alkenyl,R.sup.3 is indolyl or --NH--R.sup.6 wherein R.sup.6 is(1) aryl which may have one or more suitable substituent(s),(2) pyridyl which may have one or more suitable substituent(s), or(3) C.sub.3 -C.sub.8 cycloalkyl, andR.sup.4 is(1) hydrogen,(2) lower alkyl,(3) halogen, or(4) di(lower)alkylamino,with proviso that when R.sup.4 is hydrogen, then R.sup.2 is lower alkyl,or a pharmaceutically acceptable salt thereof.