Patent ID: 6565828
Filing Date: 2003-05-20
Classification: A61K,A61P,C07B,C07D,C07F

Abstract:
A compound of formula: or pharmaceutically acceptable salts thereof,wherein:R1, R2, and R3 are independently selected from: C1-C10 alkyl substituted with 1-5 R4, C1-C10 fluoroalkyl substituted with 1-5 R4, C2-C10 alkenyl substituted with 1-5 R4, C2-C10 fluoroalkenyl substituted with 1-5 R4, and aryl substituted with 1-5 R4, fluoroaryl substituted with 1-5 R4; R4 is independently selected at each occurrence from: C(&boxH;O)R5, S(O)2OR5, C(&boxH;O)OR5, C(&boxH;O)NR6R7, PO(OR6)(OR7); R5, R6 and R7 are independently selected from: H, C1-C10 alkyl substituted with 0-5 R8, C2-C10 alkenyl substituted with 0-5 R8, C3-C10 cycloalkyl substituted with 0-5 R8, C1-C10 fluoroalkyl substituted with 0-5 R8, C2-C10 fluoroalkenyl substituted with 0-5 R8, aryl substituted with 0-5 R8, and fluoroaryl substituted with 0-3 R8, said C1-C10 alkyl and C2-C10 alkenyl groups optionally interrupted with â€”Oâ€”, â€”Sâ€”, â€”NHâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”P(O)(OR9)Oâ€”, â€”P(O)(NHR9)Oâ€”, â€”C(O)NHâ€”, â€”NHC(O)â€”, â€”NHC(O)NHâ€”, or â€”NHC(S)NHâ€”; or alternatively, R6 and R7 may be taken together, with the atoms through which they are attached, to form a C3-C10 cycloalkyl substituted with 0-5 R8, C3-C10 cycloalkenyl substituted with 0-5 R8, aryl substituted with 0-5 R8, or fluoroaryl substituted with 0-5 R8; said C3-C10 alkyl and C3-C10 cycloalkenyl groups optionally interrupted with â€”Oâ€”, â€”Sâ€”, â€”NR9â€”, â€”S(O)â€”, â€”S(O)2-, â€”P(O)(OR9)â€”, â€”P(O)(OR9)Oâ€”, â€”P(O)(NHR9)â€”, â€”P(O)(NHR9)Oâ€”, â€”C(O)NHâ€”, â€”NHC(O)â€”, â€”NHC(O)NHâ€”, or â€”NHC(S)NHâ€”; R8 is independently selected at each occurrence from: H, â€”OH, â€”NHR9, â€”C(&boxH;O)R9, â€”OC(&boxH;O)R9, â€”OC(&boxH;O)OR9, â€”C(&boxH;O)OR9, â€”C(&boxH;O)N(R9)2, â€”PO(OR9)2, â€”SR9, â€”SOR9, â€”SO2R9, â€”NHC(&boxH;O)R9, â€”NHC(&boxH;O)NHR9, â€”CH2OR9, and â€”NHC(&boxH;S)NHR9; R9 is independently selected at each occurrence from: H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 fluoroalkyl, C1-C6 alkenyl, C3-C6 cycloalkyl, C1-C6 fluoroalkenyl, benzyl, fluorobenzyl, phenyl, and fluorophenyl; A1, A2, A3, and A4 are independently â€”(CR5R5)nâ€”, wherein n is 2 or 3; Q is a functional group selected from: wherein R10 and R11 are independently selected at each occurrence from: H, C1-C10 alkyl substituted with 0-5 R12, C3-C10 cycloalkyl substituted with 0-5 R12, C1-C10 fluoroalkyl substituted with 0-5 R12, C2-C10 alkenyl substituted with 0-5 R12, C3-C10 cycloalkenyl substituted with 0-5 R12, C2-C10 fluoroalkenyl substituted with 0-5 R12, and aryl substituted with 0-5 R12, or, alternatively, R10 and R11 may be taken together, with the atoms through which they are attached, to form a cyclic ring system, said ring system selected from: C3-C10 cycloalkyl substituted with 0-5 R12, and aryl substituted with 0-3 R12; m is 1-3; R12 is independently selected at each occurrence from the group: COR13, C(&boxH;O)OR13, C(&boxH;O)N(R13)2, PO(OR13)2, OR13, and SO2OR13; R13 is independently selected at each occurrence from the group: H, and C1-C6 alkyl; X is selected from O or NR5; and Z1, Z2, and Z3 are independently selected from: O, NH, CH2NH, and a direct bond.