Patent ID: 6265403
Filing Date: 2001-07-24
Classification: A61P,C07D

Abstract:
A compound in accordance with formula I: ##STR46##or a pharmaceutically acceptable salt or hydrate thereof, whereinX--Y.dbd.Z is N--CH.dbd.CH, CH--N.dbd.CH, or CH--CH.dbd.N;R.sup.1 is thienyl or phenyl, said thienyl and phenyl optionally substituted with one to three substituents selected from halogen, O(C.sub.1-6)alkyl, (C.sub.1-6)alkyl, and OH;R.sup.2 is C.sub.1-6 alkyl-NR.sup.7 R.sup.8 or C.sub.1-6 alkyl-heterocyclyl, wherein the heterocyclyl is piperidinyl, piperazinyl, azepinyl or morpholinyl and optionally substituted with CN, halo, or C.sub.1-6 alkyl;R.sup.3 is H, halogen, CN, O(C.sub.1-6)alkyl, (C.sub.1-6)alkyl, CO.sub.2 R, --C.sub.1-6 alkylene-CO.sub.2 R, or --C.sub.1-6 alkylene-O--C.sub.1-6 alkyl;R is H or C.sub.1-6 alkyl; andR.sup.7 and R.sup.8 are independently H, C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl, COR, --C.sub.1-6 alkylene-O--C.sub.1-6 alkyl, --C.sub.1-6 alkylene-aryl, COOR, aryl, benzyl, or NR.sup.7 R.sup.8 are taken together to form a 5-7 membered heterocyclic ring optionally containing, in addition to the nitrogen atom attached to R.sup.7 and R.sup.8, one or two non-adjacent additional hetero-atoms selected from N, O, and S, and optionally substituted with CN, halo, or C.sub.1-6 alkyl.