Patent ID: 6617451
Filing Date: 2003-09-09
Classification: C07D,C12P

Abstract:
A process for preparing a cis-&bgr;-lactam having structure II where R1 is â€”SO3(C1-C4)alkyl, â€”CH2CO2H, or â€”CH2CO2R1â€², where R1â€² is (C1-C4)alkyl, benzyl, or p-nitrophenylmethylene; R2 is benzyl or phenoxymethylene; and R3 is 2-furyl, phenyl, or 2-methoxyphenyl comprising the steps of(i) providing a racemic mixture of cis-azetidinones having structures Ia and Ib where R1 is â€”SO3(C1-C4)alkyl, â€”CH2CO2H, or â€”CH2CO2R1â€², where R1 is (C1-C4)alkyl, benzyl, or p-nitrophenylmethylene and R3 is 2-furyl, phenyl, or 2-methoxyphenyl; and (ii) reacting said racemic mixture with a (C1-C4)alkyl phenylacetate or a (C1-C4)alkyl phenoxyacetate in the presence of penicillin G amidase.