Patent ID: 9103837
Filing Date: 2015-08-11
Classification: G01N

Abstract:
1. A method of predicting whether lung function will decline in a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD, comprising detecting the level of at least one biomarker protein selected from SIGLEC7, IGFBP1, GPC2, LYVE1, PSPN, CCDC80, IGFBP-7, PIGR, ANGPT2, GSK3β, LTA LTB, FGF19, CCL5, THPO, MST1R, CHST15, COL18A1, FST, HS6ST1, LGALS3, IL10, and LGMN in a sample from the subject, wherein lung function is predicted to decline if the level of SIGLEC7, IGFBP1, LYVE1, PIGR, ANGPT2, GSK3β, CCDC80, CHST15, COL18A1, CCL5, FST, LGALS3, or LGMN is higher than a control level of the respective biomarker protein, and wherein lung function is predicted to decline if the level of GPC2, PSPN, LTA LTB, FGF19, THPO, MST1R, HS6ST1, or IL10 is lower than a control level of the respective biomarker protein, wherein the detecting comprises: (i) contacting proteins of the sample with a set of aptamers, wherein each aptamer of the set of aptamers specifically binds to a different biomarker protein being detected; (ii) separating aptamers that are bound to biomarker protein from aptamers that are not bound to biomarker protein; and (iii) detecting the separated aptamers; thereby detecting the level of the at least one biomarker protein in the sample.