Patent ID: 9163215
Filing Date: 2015-10-20
Classification: A61K,C12N,C12Q,C12Y,G01N

Abstract:
1. A method comprising: contacting a differentiated cell in vitro with an effective amount of an agent that inhibits tyrosine phosphatases and an effective amount of an agent that inhibits apoptosis, wherein the agent that inhibits tyrosine phosphatases is potassium bisperoxo(1,10-phenanthroline)oxoyanadate (bpV(phen)) and the agent that inhibits apoptosis is N-(2-Quinolybyalyl-aspartyl-(2,6- difluorophenoxy)methyl ketone (Q-VD-oPh); and generating lineage-restricted progenitor cells from the differentiated cell, wherein the differentiated cell and the lineage-restricted progenitor cells have the same lineage, wherein the differentiated cell is a myocyte and the lineage-restricted progenitor cells are myogenic progenitor cells.