Patent ID: 6664372
Filing Date: 2003-12-16
Classification: C07C,C40B

Abstract:
A process for producing precursors of a combinatorial oligoazatide library comprising the following steps:Step A: providing a soluble homopolymer support with a linker unit attached to said soluble homopolymer support in each of â€œnâ€  reaction vessels; then Step B: providing â€œnâ€  Boc-protected aza-amino acids; then Step C: reacting each of the â€œnâ€  Boc-protected aza-amino acid of said Step B with a carbonyl activation element for producing an activated carbamate of the Boc-protected aza-amino acids capable of coupling with the soluble homopolymer support or with a nascent protected chain thereon, the carbonyl activation element being bis-pentafluorophenyl carbonate; then Step D: adding one of the â€œnâ€  activated carbamates of said Step C to each of the â€œnâ€  reaction vessels and coupling the soluble homopolymer support of said Step A with the activated carbamate of said Step C for producing the nascent protected chain in each of the â€œnâ€  reaction vessels; and then Step E: washing each of the nascent protected chain by precipitation of the soluble homopolymer, thus producing precursors of the combinatorial oligoazatide library.