Patent ID: 6472371
Filing Date: 2002-10-29
Classification: A61P,C07H

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein:Y is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, â€”(CH2)mC6-C10aryl, â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the alkyl, alkenyl, aryl, heteroaryl and alkynyl groups are optionally substituted by 1 to 3 substituents independently selected from halo, cyano, nitro, trifluoromethyl, azido, â€”C(O)R21, â€”OC(O)R21, â€”NR21C(O)R22, â€”C(O)NR21 R22, â€”NR21R22, hydroxy, C1-C8 alkyl, C1-C6 alkoxy, C8-C10 aryl, and 5-10 membered heteroaryl; R1 is an alpha-branched C3-C8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group any of which may optionally be substituted by one or more hydroxyl groups; a C5-C8 cycloalkylalkyl group wherein the alkyl group is an alpha-branched C2-C5 alkyl group; a C3-C8 cycloalkyl or C5-C8 cycloalkenyl group, either of which may optionally be substituted by methyl or one or more hydroxyl or one or more C1-C4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be saturated, or fully or partially unsaturated and which may optionally be substituted by one or more C1-C4 alkyl groups or halo atoms; or R1 is phenyl which may be optionally substituted with at least one substituent selected from C1-C4 alkyl, C1-C4 alkoxy and C1-C4 alkylthio groups, halogen atoms, hydroxyl groups, trifluoromethyl, and cyano; or R1 may be with a formula (a) as shown below: â€ƒwherein X is O, S or â€”CH2â€”, a, b, c, and d are each independently an integer ranging from 0 to 2 and a+b+c+d&lE;5; or R1 is CH2R24, wherein R24 is H, C2-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, alkoxyalkyl or alkylthioalkyl containing from 1 to 6 carbon atoms in each alkyl or alkoxy group wherein any of said alkyl, alkoxy, alkenyl or alkynyl groups may be substituted by one or more hydroxyl groups or by one or more halo atoms; or a C3-C8cycloalkyl or C5-C8cycloalkenyl either or which may be optionally substituted by methyl or one or more C1-C4alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be saturated or fully or partially unsaturated and which may optionally be substituted by one or more C1-C4alkyl groups or halo atoms; or a group of the formula SR23 wherein R23 is C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C8cycloalkyl, C5-C8cycloalkenyl, phenyl or substituted phenyl wherein the substituent is C1-C4alkyl, C1-C4alkoxy or halo, or a 3 to 6 membered oxygen or sulphur-containing heterocyclic ring which may be saturated, or fully or partially unsaturated and which may optionally be substituted by one or more C1-C4alkyl groups or halo atoms; R2is H or OH; R3 is H, OH, or OCH3; R4 is H, â€”C(O)R9, â€”C(O)OR9, â€”C(O)NR9R10 or a hydroxy protecting group; R5 is â€”SR8, â€”(CH2)nC(O)R8 wherein n is 0 or 1, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, â€”(CH2)m(C6-C10 aryl), or â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R5 groups are optionally substituted by 1 to 3 R16 groups; each R6 and R7 is independently H, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, â€”(CH2)m(C6-C10 aryl), or â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4; each R8 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, â€”(CH2)qCR11R12(CH2)rNR13R14 wherein q and r are each independently an integer ranging from 0 to 3 except q and r are not both 0, â€”(CH2)m(C6-C10 aryl), or â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R8 groups, except H, are optionally substituted by 1 to 3 R16 groups; or where R8 is as â€”CH2NR8R15, R15 and R8 may be taken together to form a 4-10 membered monocyclic or polycyclic saturated ring or a 5-10 membered heteroaryl ring, wherein said saturated and heteroaryl rings optionally include 1 or 2 heteroatoms selected from O, S and â€”N(R8)â€”, in addition to the nitrogen to which R15 and R8 are attached, said saturated ring optionally includes 1 or 2 carbon-carbon double or triple bonds, and said saturated and heteroaryl rings are optionally substituted by 1 to 3 R16 groups; each R9 and R10 is independenily H or C1-C6alkyl; each R11, R12, R13 and R14 is independently selected from H, C1-C10 alkyl â€”(CH2)m(C6-C10 aryl), and â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R11, R12, R13 and R14 groups, except H, are optionally substituted by 1 to 3 R16 groups; or R11 and R13 are taken together to form â€”(CH2)pâ€” wherein p is an integer ranging from 0 to 3 such that a 4-7 membered saturated ring is formed that optionally includes 1 or 2 carbon-carbon double or triple bonds; or R13 and R14 are taken together to form a 4-10 membered monocyclic or polycyclic saturated ring or a 5-10 membered heteroaryl ring, wherein said saturated and heteroaryl rings optionally include 1 or 2 heteroatoms selected from O, S and â€”N(R8)â€”, in addition to the nitrogen to which R13 and R14 are attached, said saturated ring optionally includes 1 or 2 carbon-carbon double or triple bonds, and said saturated and heteroaryl rings are optionally substituted by 1 to 3 R16 groups; R16 is H, C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, wherein the foregoing R16 groups are optionally substituted by 1 to 3 substituents independently selected from halo and â€”OR9; each R16 is independently selected from halo, cyano, nitro, trifluoromethyl, azido, â€”C(O)R17, â€”C(O)OR17, â€”C(O)OR17, â€”OC(O)OR17, â€”NR6C(O)R7, â€”C(O)NR6R7, â€”NR6R7, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, â€”CH2)m(C6-C10 aryl), and â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein said aryl and heteroaryl substituents are optionally substituted by 1 or 2 substituents independently selected from halo, cyano, nitro, trifloromethyl, azido, â€”C(O)R17, â€”C(O)OR17, â€”C(O)OR17, â€”OC(O)OR17, â€”NR8C(O)R7, â€”C(O)NR6R7, â€”NR6R7, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy; each R17 is independently selected from H, C1-C10 alkyl C2-C10 alkenyl, C2-C10 alkynyl, â€”(CH2)m(C6-C10 aryl), and â€”CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, provided that R8 is not H where R19 is â€”CH2S(O)nR6; R16 is OH; R15 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, cyano, â€”CH2S(O)nR8 wherein n is an integer ranging from 0 to 2, â€”CH2OR8, â€”CH2N(OR9)R8, â€”CH2NR8R15, â€”(C2)m(C6-C10 aryl), or â€”(CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R19 groups are optionally substituted by 1 to 3 R16 groups; or R18 and R19 are taken together to form an oxazolyl ring as shown below â€ƒand; each R21 and R22 is independently H, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkenyl, (CH2)m(C5-C10) aryl, (CH2)m(5-10 membered heteroaryl), wherein m is an integer ranging from 0 to 4, or C2-C10 alkylyl.