Patent ID: 7955835
Filing Date: 2011-06-07
Classification: C07D,C12P

Abstract:
1. A process for producing a compound of formula I and a compound of formula VII: wherein R R said process comprising: a) subjecting a compound of formula II: to an enzymatic diastereomeric resolution in the presence of a suitable amount of Pig Liver Esterase enzyme or Porcine Pancreatic Lipase enzyme, wherein said resolution is conducted in the presence of a solvent selected from water, C 1-12 alkanol, toluene, acetonitrile, tetrahydrofuran, dimethylformamide, dimethylsulfonamide, N-methylpyrrolidone, isooctane, t-butylmethyl ether, and mixtures thereof; and b) recovering compounds of formula I and formula VII.