Patent ID: 6509474
Filing Date: 2003-01-21
Classification: C07B,C07D

Abstract:
Method of lithiating CH-acidic five-membered heterocycles, wherein the five-membered heterocycle is reacted with metallic lithium in an ether-containing solvent in the presence of an H acceptor, and the CH-acidic bond of the five-membered heterocycle has a pKa value of 30 to 40 and the H acceptor isan open-chain, unsubstituted or substituted wherein R1, R2 =H, alkyl, vinyl,wherein R1, R2 in cis or trans configurationor a cyclic 1,3-diene whereinn=1 to 5 and is used in a quantity of 0.2 mol to 3 mol per mol of five-membered heterocycle.