Patent ID: 8962265
Filing Date: 2015-02-24
Classification: A61K,C12Q,G01N

Abstract:
1. A method of identifying a compound, comprising the steps of: providing at least one translation initiation factor identified in a single celled eukaryotic parasite, wherein the translation initiation factor is phosphorylated by a TgIF2K-D kinase having at least 90% identity to SEQ ID NO: 13; contacting the TgIF2k-D kinase of SEQ ID NO: 13 with at least one compound; measuring the activity of the TgIF2K-D kinase of SEQ ID NO: 13 in the presence of the at least one compound; and identifying the at least one compound as an inhibitor of TgIF2K-D kinase of SEQ ID NO: 13 if the at least one compound reduces the activity of the TgIF2K-D kinase of SEQ ID NO: 13.