Patent ID: 6787558
Filing Date: 2004-09-07
Classification: A61P,C04B,C07D

Abstract:
A compound of formula I whereinR1 is â€”Oâ€”R4 or â€”NR5R6; R2 is hydrogen, alkyl, cycloalkyl, alkoxy, halogen, heterocyclyl or amino; R3 is hydrogen, alkyl, amino or halogen; R4 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, alkoxyalkyl, hydroxyalkyl or heterocyclyl; R5 and R6 are independently selected from hydrogen, alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, alkoxyalkyl, hydroxyalkyl or heterocyclyl; or R5 and R6 together with the N atom to which they are attached form a 5- to 10-membered heterocyclic ring wherein the hetorocyclyc ring is optionally substituted with one or more substituents independently selected from alkyl or alkoxy; A1 is a substituted or unsubstituted pyrrolidine ring, wherein the pyrrolidine ring is substituted, the substituent is one to three substituents independently selected from alkyl, alkoxy, hydroxy, hydroxyalkyl, alkoxyalkyl, amino, acetylamino, cyano, tetrahydropyranyloxyalkyl or cycloalkylalkoxy; A2 is â€”CH2â€” or â€”C(O)â€”; or a pharmaceutically acceptable salt or ester thereof.