Patent ID: 6767909
Filing Date: 2004-07-27
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof whereinR1, R2, R3, R4 and R5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain having 1 to 4 carbon atoms, phenyl or â€”OH; Z is H, acetyl, â€”CH2â€”Phâ€”Oâ€”CF3 or â€”CH2â€”Phâ€”CF3, where Ph is phenyl; Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms, wherein the ring structure is a) phenyl optionally mono- or disubstituted, wherein each substituent is independently selected from the group consisting of a halogen, a straight or branched alkyl or alkoxy chain with 1 to 4 carbon atoms, a halogen substituted methyl or methoxy group, a nitrile group, an amide group, an amino group, and a nitro group; b) 2-benzimidazolyl, 2-imidazolyl, or 2- or 3-indolyl, wherein one N optionally has a substituent that is a straight or branched alkyl or alkoxy chain with 1 to 4 carbon atoms, or benzyl; and wherein the 2-benzimidazolyl, 2-imidazolyl, or 2- or 3-indolyl is optionally mono- or disubstituted, wherein each substituent is independently a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; (c) pyridinyl optionally mono- or disubstituted, wherein each substituent is independently a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; or (d) naphthyl optionally mono- or disubstituted, wherein each substituent is independently a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; provided that if R1 is methyl; and R2, R4, R5, Z and X is H; then Y cannot be an unsubstituted 2-benzimidazolyl if R3 is methyl or H, nor can Y be a monosubstituted 2-benzimidazolyl wherein one N has a methyl or ethyl substitution if R3 is methyl, and provided that the compound of formula 1 cannot be N-(4-methyl-2-pyrimidinyl)-4-[[(1-methyl-1H-benzimidazol-2-yl )methyl]amino-benzene.