Patent ID: 7127357
Filing Date: 2006-10-24
Classification: G16B

Abstract:
1. A method of identifying a Pin1 WW domain binding agent, said method comprising: determining the ability of a potential binding agent to compete with a known Pin1 WW domain substrate for binding to a Pin1 WW domain by contacting said potential binding agent with said Pin1 WW domain in the presence of said known Pin1 WW domain substrate, wherein the potential binding agent is modeled on a computer to fit spatially into a Pin1 WW domain interaction site using a plurality of atomic coordinates obtained from a Pin1 WW domain crystallized in co-complex with a known Pin1 WW domain binding agent, substrate, or inhibitor, wherein said plurality of atomic coordinates are as set forth in Table 1, and wherein a potential binding agent which competes with a known Pin1 WW domain substrate for binding to a Pin1 WW domain is identified as a Pin1 WW domain binding agent.