Patent ID: 6034084
Filing Date: 2000-03-07
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR6## wherein: A is --N.dbd.;Z.sup.1 and Z.sup.2 are each --O--, --S-- or --N(R.sup.12)--;R.sup.1 and R.sup.4 are independently hydrogen, halo, alkyl or --OR.sup.12 ;R.sup.2 is --C(NH)NH.sub.2, --C(NH)N(H)C(O)R.sup.12, or --C(NH)N(H)S(O).sub.2 R.sup.15 ;R.sup.3 is ureido, guanidino, --OR.sup.12, --C(NH)NH.sub.2, --C(O)N(R.sup.12)R.sup.13, --N(R.sup.12)R.sup.13, (1,2)-tetahydropyrimidinyl (optionally substituted by alkyl), (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);R.sup.5 and R.sup.6 are independently hydrogen, halo, alkyl, or haloalkyl;R.sup.7 is --S(O).sub.n --(C(R.sup.12)(R.sup.13)).sub.p --R.sup.16 (where n is 0 to 2 and p is 0 to 4);R.sup.11 is --C(O)OR.sup.12 or --C(O)N(R.sup.12)R.sup.13 ;each R.sup.12 and R.sup.13 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl);R.sup.15 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); andR.sup.16 is a mono-, bi- or tricyclic heterocyclic ring system containing from 3 to 15 ring members including carbon and 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, wherein the carbon, nitrogen and sulfur atoms may be optionally oxidized and wherein the heterocyclic ring system may be partially or fully saturated or aromatic and is substituted by --(C(R.sup.12)(R.sup.13)).sub.p --R.sup.11 (where p is 0 to 4 and R.sup.11 is defined above), and is optionally substituted by alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, halo, haloalkyl, haloalkoxy, hydroxy, --N(R.sup.12)R.sup.13, --C(O)OR.sup.12, or --C(O)N(R.sup.12)R.sup.13 ;as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.