Patent ID: 8691839
Filing Date: 2014-04-08
Classification: A61K,A61P,C07C,C07D,C07F

Abstract:
1. A method for treating a movement disorder comprising the steps of: administering to a recipient, a compound of formula I wherein R is OR1, di(C1-C3)alkylamino, SH, S(C1-C3)alkyl or NHR3; R1 is hydrogen, a group —C(═O)R2, —SO R2 is (C1-C6)alkyl, (C1-C6)alkyloxy, phenyl, phenyl(C1-C3)alkyl or phenyl(C1-C3)alkyloxy, wherein the phenyl group is optionally substituted with one or more substituents selected from (C1-C3)alkoxy, (C1-C3)alkyl, halogen, or CF R3 is hydrogen, (C1-C3)alkyl, formyl, (C1-C3)alkylcarbonyl, (C1-C3)alkoxycarbonyl, or (C1-C3)alkylamino carbonyl; Cy is an aromatic, heteroaromatic or non-aromatic cyclic group X, Y or Z, wherein X is a 5 membered aromatic or heteroaromatic ring which is unsubstituted or substituted with one or two groups R4, or a 6 membered aromatic or heteroaromatic ring which is substituted with one or two groups R4; Y is a bicyclic aromatic or heteroaromatic ring system which is unsubstituted or substituted with one to three groups R5 and which ring system is selected from among wherein the bond crossed by a dotted line indicates the attachment site of the group Y to the aminotetraline scaffold; wherein each R4 and R5 is independently selected from halogen, hydroxyl, CF Z is adamantyl which is unsubstituted or substituted with methyl and/or hydroxyl, including its enantiomers and pharmaceutically acceptable salts.