Patent ID: 7638649
Filing Date: 2009-12-29
Classification: C07B,C07C,Y02P

Abstract:
1. A method of preparation of (R)-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of formula I wherein a. a protecting group is introduced to N-[(1R)-2-(4-methoxyphenyl)-1-methylethyl]-N-[(1R)-1-phenylethyl)]amine of formula VIII to obtain an amide of formula IX wherein A can be an acyl having 2 to 8 carbons, b. whereupon the amide of formula IX is chlorosulfonated and the resulting sulfochloride is converted to a sulfonamide of formula X wherein A is as defined above, c. and the sulfonamide of formula X is hydrogenated to obtain the compound of formula I.