Patent ID: 6747035
Filing Date: 2004-06-08
Classification: A61P,C07D

Abstract:
A compound of formula (I), in whichR1 is: hydroxyl, halogen, nitro, mercapto, cyano or carboxyl, lower alkyl or lower alkoxy, these groups being optionally substituted with 1,2 or 3 halogen atoms, or â€”NR4R5 in which R4 and R5 are the same or different and are: H, lower alkyl, optionally substituted with 1,2 or 3 halogen, hydroxyl, cyano and lower alkoxy, or C(&boxH;O)R6 in which R6 is selected from: lower alkyl optionally substituted with OR7, or SR7 and â€”X1-cycloalkyl optionally substituted with OR7, SR7, NR7R8 or with a linear or branched C1-C4 alkyl, in which R7 and R8 are the same or different and are hydrogen or lower alkyl and X1 is a single bond or a linear or branched C1-C4 alkylene;R2 is: lower alkyl optionally substituted with OR9, SR9, or â€”X2-cycloalkyl optionally substituted with OR9, SR9, NR9R10 or with a linear or branched C1-C4 alkyl, in which R9 and R10 are the same or different and are hydrogen or lower alkyl and X2 is a single bond or a linear or branched C1-C4 alkylene; andR3 is: in which:n is an integer from 1 to 4, Ar is an aromatic ring comprising 5 or 6 atoms comprising zero to three O, S or N, and Y1, Y2 and Y3, which may be identical or different, are: hydrogen, hydroxyl, halogen, mercapto, nitro, C(=O)R11, C(=O)OR11, C(&boxH;O)NR12R13, NR12R13 or â€”(CH2)SCN in which s is an integer from 0 to 2; R11, R12 and R13 are each independently hydrogen or lower alkyl, lower alkyl or lower alkoxy, each optionally substituted with 1, 2 or 3 halogen atoms, or â€”S(O)mR14 in which m is 0 or 1 and R14 is lower alkyl, an isomer thereof or a pharmaceutically acceptable salt thereof.