Patent ID: 7285539
Filing Date: 2007-10-23
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A composition comprising hepatitis C virus (HCV) polynucleotides, wherein the HCV polynucleotides comprise HCV coding sequences, wherein the HCV coding sequences consist of: (a) an isolated and purified polynucleotide encoding an NS3 polypeptide of a hepatitis C virus (HCV); (b) an isolated and purified polynucleotide encoding an NS4 polypeptide of a HCV; (c) an isolated and purified polynucleotide encoding an NS5a polypeptide of a HCV; and (d) an isolated and purified polynucleotide encoding an NS5b polypeptide of a HCV; wherein at least one of the polynucleotides encoding NS3, NS4, NS5a or NS5b is provided separately from the other polynucleotides and is adsorbed to a microparticle, and further wherein said composition includes a pharmaceutically acceptable excipient and optionally an adjuvant.