Patent ID: 6329378
Filing Date: 2001-12-11
Classification: C07C,C07D

Abstract:
A compound of formula (I) ##STR12##whereinY is CH when the dotted line leading from Y to N is present and represents a bond, or CH.sub.2 when the dotted line leading from Y to N is absent;R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are carbon;X.sup.1 is selected from the group consisting of ZH, where Z is O or S, or NR.sup.21 R.sup.22, wherein R.sup.21 and R.sup.22 are independently selected from the group consisting of hydrogen, alkyl or acyl;X.sup.2, X.sup.3, X.sup.4 and X.sup.5 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, alkenyl, alkynyl, acyl, alkoxy, alkenyloxy, alkynyloxy, acyloxy, cyano, trifluoromethyl, nitro, aryl, heteroaryl, a non-aromatic heterocyclic group, a fused or polycyclic ring structure, N-alkyl amino, N-alkenyl amino, N-alkynyl amino, N-acyl amino, N,N-alkyl amino, N,N-alkenyl amino, N,N-alkynyl amino, N,N-acyl amino, thio, sulfonamide, and SO.sub.2 ; or are independently selected from the group consisting of(a) C(O)NHQ.sup.1 Q.sup.2, wherein Q.sup.1 is C.sub.1-3 alkyl and Q.sup.2 is aryl, heteroaryl or a non-aromatic heterocyclic group, wherein said aryl, heteroaryl or non-aromatic heterocyclic group is optionally substituted with hydroxyl, alkyl, alkoxy, carboxyl, or acyl; or(b) C(O)Q.sup.3, wherein Q.sup.3 is selected from the group consisting of hydrogen, OH, O--C.sub.1-3 alkyl; or(c) SO.sub.2 Q.sup.4, wherein Q.sup.4 is aryl, heteroaryl or non-aromatic heterocyclic, wherein said aryl, heteroaryl or non-aromatic heterocyclic is optionally substituted with hydroxyl, alkyl, alkoxy, carboxyl or acyl; or(d) OQ.sup.5 Q.sup.6, wherein Q.sup.5 is C.sub.1-3 alkyl and Q.sup.6 is aryl, heteroaryl or a non-aromatic heterocyclic group, wherein said aryl, heteroaryl or non-aromatic heterocyclic group is optionally substituted with hydroxyl, allyl, alkoxy, carboxyl, or acyl;R.sup.6 and R.sup.9 are nitrogen;R.sup.7, R.sup.8 and R.sup.10 are carbon;X.sup.6 and X.sup.9 are absent;X.sup.7, X.sup.8 and X.sup.10 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, alkenyl, alkynyl, acyl, alkoxy, alkenyloxy, alkynyloxy, acyloxy, cyano, trifluoromethyl, nitro, aryl, heteroaryl, a non-aromatic heterocyclic group, a fused or polycyclic ring structure, N-alkyl amino, N-alkenyl amino, N-alkynyl amino, N-acyl amino, N,N-alkyl amino, N,N-alkenyl amino, N,N-alkynyl amino, N,N-acyl amino, thio, sulfonamide, and sulfonyl; or are independently selected from the group consisting of(a) C(O)NHQ.sup.1 Q.sup.2, wherein Q.sup.1 is C.sub.1-3 alkyl and Q.sup.2 is aryl, heteroaryl or non-aromatic heterocyclic group, wherein said aryl, heteroaryl or non-aromatic heterocyclic group is optionally substituted with hydroxyl, alkyl, alkoxy, carboxyl, or acyl; or(b) C(O)Q.sup.3, wherein Q.sup.3 is selected from the group consisting of hydrogen, OH, O--C.sub.1-3 alkyl; or(c) SO.sub.2 Q.sup.4, wherein Q.sup.4 is aryl, heteroaryl or non-aromatic heterocyclic, wherein said aryl, heteroaryl or non-aromatic heterocyclic is optionally substituted with hydroxyl, alkyl, alkoxy, carboxyl or acyl; or(d) OQ.sup.5 Q.sup.6, wherein Q.sup.5 is C.sub.1-3 alkyl and Q.sup.6 is aryl, heteroaryl or a non-aromatic heterocyclic group, wherein said aryl, heteroaryl or non-aromatic heterocyclic group is optionally substituted with hydroxyl, alkyl, alkoxy, carboxyl, or acyl;or a pharmaceutically acceptable salt thereof.