Patent ID: 8603435
Filing Date: 2013-12-10
Classification: A61K,C07K,G01N

Abstract:
1. A compound according to the chemical structure: Wherein Y is a chelate group, said chelate group optionally incorporating or complexing with a radioisotope; Each X is independently an amino acid residue which may be optionally acylated at its amino terminal end or an amino acid linker according to the chemical structure: ABC is an amino acid linker wherein A is absent or is a neutral or negatively charged amino acid at physiological pH which is optionally acylated at its amino terminal end; B is a neutral or negatively charged amino acid at physiological pH which is optionally acylated at its amino terminal end; C is absent or is a neutral or negatively charged amino acid at physiological pH; m is an integer from 0 to 250; n is 0 or 1; p is an integer from 0 to 20; q is 0 or 1, and Cycpeptide is a cyclic peptide comprising between 11 and 13 amino acids according to the structure: Wherein X is norleucine (Nle), leucine or isoleucine; Y Z is glycine or alanine; W is valine, leucine or isoleucine; T is aspartic acid, glutamic acid or a Where Z j is 0, 1 or 2; r is an integer from 0 to 250; s is 1; w is 0 to 20; or a pharmaceutically acceptable salt thereof, optionally complexed with at least one radioisotope, selected from the group consisting of