Patent ID: 6013634
Filing Date: 2000-01-11
Classification: A61P,C07H

Abstract:
A solid support matrix of the formula: ##STR8## wherein SS is a solid support; R.sup.1 is selected from the group consisting of a covalent bond and a hydrocarbylene group having from 1 to about 20 carbon atoms;R.sup.2 is a hydrocarbylene group of from 2 to 20 carbon atoms;each X' is independently selected from the group consisting of --O-- and >NR.sup.4 wherein each R.sup.4 is independently selected from hydrogen, R.sup.2 NH.sub.2 or R.sup.2 NR.sup.3 Z wherein R.sup.2 is as defined above;R.sup.3 is selected from the group consisting of hydrogen and --C(O)R.sup.5 wherein R.sup.5 is selected from the group consisting of hydrogen and hydrocarbyl of from 1 to 20 carbon atoms;W is selected from oxygen or sulfur;X is selected from the group consisting of --NH--, --O-- and --S--;Y is selected from the group consisting of --NH--, --O-- and --S--;Z is toxin-binding oligosacchlaride;p is an integer from 0 to 50; andn is an integer such that the matrix has a loading level of the toxin-binding oligosaccharide of from about 0.001 to about 2000 .mu.moles per grain of solid supportwherein the total number of atoms separating the solid support from the toxin-binding, oligosaccharide is at least 6.