Patent ID: 9084822
Filing Date: 2015-07-21
Classification: A61K

Abstract:
1. A freeze-dried solid form consisting essentially of a biodegradable copolymer and an amide compound, wherein the biodegradable copolymer has a structure represented by Formula (I) or Formula (II): wherein A comprises a hydrophilic block of polyethylene glycol polymer, B comprises a hydrophobic block of polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0; wherein the amide compound is selected from the group consisting of: and combinations thereof; and wherein the biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the amide compound.