Patent ID: 6080873
Filing Date: 2000-06-27
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR64## or the pharmaceutically acceptable salts thereof wherein: ##STR65## independently represent a carbon chain optionally substituted with hydrogen, halogen, or straight or branched chain lower alkyl having 1-6 carbon atoms;whereinm is 1, 2, or 3; andn is 1 or 2;T is halogen, hydrogen, hydroxyl, amino or alkoxy having 1-6 carbon atoms;X is hydrogen, hydroxyl, or alkyl;Z is amino, mono or dialkylamino where each alkyl is independently alkyl or cycloalkyl having 3-7 carbon atoms, or NR.sub.9 COR.sub.10 where R.sub.9 and R.sub.10 are the same or different and represent hydrogen or alkyl or cycloalkyl having 3-7 carbon atoms; andR.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and are selected from hydrogen, alkyl , --COR.sub.11 or --CO.sub.2 R.sub.11 where R.sub.11 is alkyl or cycloalkyl having 3-7 carbon atoms; or --CONR.sub.12 R.sub.13 where R.sub.12 and R.sub.13 are selected independently from hydrogen, alkyl, cycloalkyl having 3-7 carbon atoms, phenyl, 2-, 3-, or 4-pyridyl, or NR.sub.12 R.sub.13 forms a heterocyclic group which is morpholinyl, piperidinyl, pyrrolidinyl, or N-alkyl piperazinyl; orR.sub.3 -R.sub.4 may be taken together to form a cyclic moiety having 3-7 carbon atoms; orR.sub.5 -R.sub.6 may be taken together to form a cyclic moiety having 3-7 carbon atoms; andwhere each alkyl group forming an R.sub.3, R.sub.4, R.sub.5, or R.sub.6 substitutent or portion thereof may be substituted independently with hydroxy or mono- or dialkylamino where each alkyl is independently alkyl or cycloalkyl having 3-7 carbon atoms.Y represents hydrogen or halogen.