Patent ID: 9044507
Filing Date: 2015-06-02
Classification: A61K,C07K,C12N

Abstract:
1. A method of suppressing, in a mammalian recipient receiving a viral vector for gene therapy or for gene vaccination which encodes a therapeutic protein, an immune response to a protein encoded by said viral vector, other than the therapeutic protein, comprising the step of administering to said recipient an immunogenic peptide of between 12 and 50 amino acids comprising (i) a T-cell epitope of said protein encoded by said viral vector; and (ii) a C-(X)2-[CST] or [CST]-(X)2-C motif, wherein said C-(X)2-[CST] or [CST]-(X)2-C motif is immediately adjacent to said T-cell epitope, or is separated from said T-cell by a linker of at most 7 amino acids.