Patent ID: 8921058
Filing Date: 2014-12-30
Classification: A61K,C07K,G01N

Abstract:
1. A method comprising: (a) providing a sample of a prostate tissue; (b) detecting whether the sample of the prostate tissue expresses at least one tumor marker selected from the group consisting of: wherein the detecting is performed by immunohistochemical analysis using an antibody that specifically binds to the at least one tumor marker; (c) determining that the expression of the at least one tumor marker in the sample of the prostate tissue is (d) identifying the sample of the prostate tissue expressing the at least one tumor marker at a higher level than in the non-malignant prostate tissue control sample as having a prostate malignancy, and identifying the sample of the prostate tissue expressing the at least one tumor marker at the same or lower level than in the non-malignant prostate tissue control sample as not having a prostate malignancy, and (e) administering to a subject from whom the sample of the prostate tissue is obtained that expresses the at least one tumor marker at a higher level than in the non-malignant prostate tissue control sample, a monoclonal antibody that specifically binds the at least one tumor marker for treating the prostate malignancy.