Patent ID: 6872853
Filing Date: 2005-03-29
Classification: A61K,A61P,C07C

Abstract:
1. A process for the preparation of polymorphic form II of sertraline hydrochloride, wherein a solution of sertraline free amino is seeded with some crystals, of polymorphic form II before addition of a solution of hydrogen chloride, or wherein a stirred suspension of sertraline hydrochloride polymorphic form V is stirred with some seeding crystals of sertraline hydrochloride polymorphic form II, or wherein sertraline hydrochloride alcohol solvate is dried at temperatures from 0 to 30° C. in a high vacuum of less than 1 mbar, or wherein suspensions of sertraline hydrochloride polymorphic form CSC1, CSC2 or T1 are stirred with some seeding crystals of sertraline hydrochloride polymorphic form II.