Patent ID: 6639059
Filing Date: 2003-10-28
Classification: C07H

Abstract:
A method for the synthesis of a compound of the general formula II: whereinR1 is selected form optionally substituted aryl(C1-6-alkyl), optionally substituted tetrahydropyran-2-yl, optionally substituted arylcarbonyl and optionally substituted aryl; each of the substituents R2 and R3 is independently selected from hydrogen, optionally substituted C1-6-alkyl, optionally substituted aryl, and optionally substituted aryl(C1-6-alkyl), or R2 and R3 together designate C3-7-alkylene, with the proviso that R2 and R3 are not both hydrogen; and each of the substituents R4 and R5 independently is Râ€²SO2Oâ€” wherein Râ€² is selected from optionally substituted alkyl and optionally substituted aryl; said method comprising the following step:treatment of a compound of the general formula I: whereinR1 is selected form optionally substituted aryl(C1-6-alkyl), optionally substituted tetrahydropyran-2-yl, optionally substituted arylcarbonyl and optionally substituted aryl; each of the substituents R2 and R3 is independently selected from hydrogen, optionally substituted C1-6-alkyl, optionally substituted aryl, and optionally substituted aryl(C1-6-alkyl), or R2 and R3 together designate C3-7-alkylene, with the proviso that R2 and R3 are not both hydrogen; and with Râ€²SO2X wherein Râ€² is selected from optionally substituted C1-6-alkyl and optionally substituted aryl, and X designates halogen.