Patent ID: 6455699
Filing Date: 2002-09-24
Classification: A61K,A61P,C07D,C07F

Abstract:
A compound having the structure: wherein R1 is hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group, an aryloxy group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, â€”C(O)Rf, wherein Rf is an alkyl group, a haloalkyl group, an alkoxyl group, an amino group or a hydroxyl group, an amino group, â€”SRc, wherein Rc is hydrogen, â€”C(O)Rf, an alkyl group, or an aryl group, â€”OC(O)Rd or â€”OC(O)ORd, wherein Rd is an alkyl group; wherein R2 is an alkenyl group, an alkynyl group, an alkoxyl group, an aryloxy group, a carbamoyloxy group, a halogen, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, â€”C(O)Rf, wherein Rf is an alkyl group, a haloalkyl group, an alkoxyl group, an amino group or a hydroxyl group, an amino group, â€”SRc, wherein Rc is hydrogen, â€”C(O)Rf, an alkyl group, or an aryl group, â€”OC(O)Rd or â€”OC(O)ORd, wherein Rd is an alkyl group; or R1 and R2 together form a group of the formula â€”O(CH2)nOâ€” wherein n represents the integer 1 or 2; R3 is H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano group; or R2 and R3 together form a group of the formula â€”O(CH2)nOâ€” wherein n represents the integer 1 or 2; R4 is H, F, a C1-3 alkyl group, a C2-3 alkenyl group, a C2-3 alkynyl group, or a C1-3 alkoxyl group; R5 is a C1-10 alkyl group, or a propargyl group; and R6, R7 and R8 are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group or a â€”(CH2)NR9 group, wherein N is an integer within the range of 1 through 10 and R9 is a hydroxyl group, alkoxy group, an amino group, an alkylamino group, a dialkylamino group, a halogen atom, a cyano group or a nitro group; and pharmaceutically acceptable salts thereof.