Patent ID: 8362085
Filing Date: 2013-01-29
Classification: A61K,A61P,Y10S

Abstract:
1. A method of treating a patient with a neurological disorder selected from the group consisting of Alzheimer's disease, dementia, Parkinson's disease, and neuropathic pain, comprising: administering to said subject once daily a sustained release oral dosage form comprising 22.5 mg to 30 mg of memantine or a pharmaceutically acceptable salt thereof and a component that sustains release of said memantine or salt thereof, wherein said sustained release memantine provides a change in mean plasma concentration of memantine as a function of time (dC/dT) that is: (a) less than about 50% of the dC/dT provided by the same quantity of an immediate release form of memantine, determined in a time period between 0-Tmax of the immediate release form of memantine; and (b) 2.1 ng/ml/hr or less, determined in a time period of 0 to 4 hours; wherein dC/dT is measured in a single-dose human PK study.