Patent ID: 7163920
Filing Date: 2007-01-16
Classification: A61K,A61L

Abstract:
1. An osteoinductive composition comprising an isolated or recombinant peptide component having the formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is H; formyl; mono- or di-lower (C1–C8 linear or branched) alkyl; aryl; lower (C1–C8 linear or branched) alkanoyl; aroyl; aroyl substituted with 1–3 substituents selected from the group consisting of fluorine, chlorine, bromine, C 1–C8 linear or branched alkyl, and C1–C8 linear or branched alkyloxy; C1–C8 linear or branched alkyloxycarbonyl; aryloxycarbonyl; or aryloxycarbonyl substituted with 1–3 substituents selected from the group consisting of fluorine, chlorine, bromine, C1–C8 linear or branched alkyl, and C1–C8 linear or branched alkyloxy; R 2 and R 8 are each independently selected from D-cysteine, L-cysteine, D-homocysteine, L-homocysteine, D-penicillamine, or L-penicillamine; R 3 , R 4 and R 5 are each glycine; or R 3 and R 4 taken together are δ-amino-pentanoic acid; or R 4 and R 5 taken together are δ-amino-pentanoic acid; R 6 is arginine or homo-arginine; R 7 is tryptophan; R 9 is glycine; and R 10 is OH, C1–C8 linear or branched alkyl ester, lower aryl ester, or NR 11 R 12 where R 11 and R 12 are each selected independently from H, C1–C8 linear or branched alkyl, or aryl.