Patent ID: 6200590
Filing Date: 2001-03-13
Classification: A61K,Y10S

Abstract:
A four-stage, phased-release drug delivery means, comprising a suppository preparation comprising drug-ladened, polymeric synthesized microscopic particles within a pharmaceutically acceptable suppository base component wherein said microscopic particles have been specially formulated as a homogeneous matrix of active agent(s) and biodegradable polymers wherein the process for formulating said microscopic particles produces drug-ladened spheres no larger than 300 nanometers in diameter, the size and formulation of which allows these ""nanoparticles"" to be delivered, substantially intact, across the fenestrated capillaries of the rectal or vaginal mucosa for the controlled release of active agent(s) directly into the subject's systemic circulation; said four-stage, phased-release, delivery means comprising first, the delivery of the suppository containing said drug-ladened nanoparticle spheres into the rectal or vaginal cavity; second, the aquaous solubility of the chosen suppository base component; third, the uptake of said nanoparticle spheres into the fenestrated capillaries of the chosen cavity; and fourth, the release of active agent(s), controlled by the percentage composition of polymers used in the production of the nanoparticles, directly into the subject's systemic circulation.