Patent ID: 7943587
Filing Date: 2011-05-17
Classification: A61K,A61P,C12N

Abstract:
1. A method of inducing an enhanced specific immune response against an immunogen in an individual comprising the steps of: identifying a Major Histocompatibility Complex antigen (MHC) subtype of the individual that forms a MHC/immunogen/T cell receptor (TCR) complex in the individual that is essential in induction of immune responses against the immunogen; and administering to said individual at a site on said individual's body, a first plasmid and a second plasmid, wherein said first plasmid comprises a nucleotide sequence that encodes an immunogen operably linked to regulatory elements necessary for expression in said individual and said second plasmid comprises a nucleotide sequence that encodes the Major Histocompatibility Complex Class I antigen subtype operably linked to regulatory elements necessary for expression in said individual, wherein said first and second plasmids are taken up by a cell of said individual, said nucleotide sequences that encode said immunogen and said Major Histocompatibility Complex Class I antigen subtype are expressed and an enhanced specific immune response against said immunogen is induced in said individual; and wherein the immunogen is a pathogen antigen.