Patent ID: 6545004
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A compound of a formula: whereinR1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(isopropylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is p-chlorobenzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(dimethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is m-methoxybenzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is isopropyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is azetidin-3-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-aminoethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-aminoethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(methylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(methylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(methylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is azetidin-2-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is methylsulfinylmethyl; R2â€² is hydrogen; R3 is p-toyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is piperidin-3-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is fluoro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-aminoethyl; R5, R6, R7 and R8 are hydrogen; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is piperidin-2-yl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 4-aminobutyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is m-chlorobenzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(piperidin-1-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(imidazol-3-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is pyrrolidin-3-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(diethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-chlorophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 4-aminobutyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is pyrrolidin-2-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(azetidin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(pyrrolidin-1-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(pyrrolidin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(dimethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is propyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(pyrrolidin-1-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(pyrrolidin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is piperidin-4-ylmethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is methylsulfinylethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(piperidin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is benzyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is (N-ethylpyrrolidin-2-yl)methyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-piperidinyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 4-piperidinyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is p-chlorobenzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2,2-dimethyl-3-(dimethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 5-aminopentyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-(dimethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is fluoro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(2-methylpiperidin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is fluoro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(N-methylpyrrolidin-2-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-trifluoromethylphenyl; R4 is 3-(dimethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(diethylamino)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 3-(N-methylpiperazin-1-yl)propyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is 4-(CBZ)aminobutyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is aminoethoxyethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is 2-naphthyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro R1 is benzyl; R2 is cyclohexylmethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(piperidin-1-yl)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-hydroxypropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-fluorophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 6-aminohexyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(dimethylamino)ethyl; R5, R7, and R8 are hydrogen; and R6 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is fluoro; R1 is benzyl; R2 is methyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-aminoethyl; R5, R6, R7 and R8 are hydrogen; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R7 are hydrogen; and R8 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R6, R7, and R8 are hydrogen; and R5 is chloro; R1 is benzyl; R2 is aminobutyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 3-aminopropyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-tolyl; R4 is 2-(dimethylamino)ethyl; R5 and R8 are hydrogen; and R6 and R7 are fluoro; R1 is m-tolyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5, R6, and R8 are hydrogen; and R7 is chloro; R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-(dimethylamino)ethyl; R5 and R8 are hydrogen; and R6 and R7 are fluoro; or R1 is benzyl; R2 is ethyl; R2â€² is hydrogen; R3 is p-bromophenyl; R4 is 2-carboxyethyl; R5, R6, and R8 are hydrogen; and R7 is chloro, or a pharmaceutically acceptable salt of any of the foregoing compounds.