Patent ID: 9175320
Filing Date: 2015-11-03
Classification: A61P,C07B,C07C,C07D,C12P

Abstract:
1. A process for preparing (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia): comprising the step of hydrolyzing a compound of Formula (IIk):  wherein R in the presence of a lipase and a hydrolyzing-step solvent to form said (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia).