Patent ID: 6991806
Filing Date: 2006-01-31
Classification: A61K,A61P

Abstract:
1. A stable pharmaceutical composition comprising a mixture of (i) an ibuprofen medicament; (ii) 0.1 to 20% by weight of a domperidone medicament based on the total weight of the composition; and (iii) a carrier material characterized in that the carrier material is substantially free of povidone and comprises at least one diluent combined with at least one disintegrating agent excluding (a) a compressed tablet comprising granulated ibuprofen and a carrier-material consisting essentially of either maize starch at 35–38% total tablet weight in combination with dried maize starch at 3–4% total tablet weight or microcrystalline cellulose at 10–11% total tablet weight in combination with croscarmellose sodium at 14–16% total tablet weight and pre-gelled starch at 10% total tablet weight; (b) a direct compression tablet comprising a carrier material consisting essentially of microcrystalline cellulose at 8–11% total tablet weight and lactose at 5–6% total tablet weight; (c) a hard gelatin capsule comprising a carrier consisting essentially of maize starch at 15–20% total capsule contents weight in combination with pre-gelled starch at 5–6% total capsule contents weight.