Patent ID: 6509349
Filing Date: 2003-01-21
Classification: A61P,C07D

Abstract:
A compound having a structure according to Formula (I) wherein:(A) (1) R1 is selected from C3 to about C6 cycloalkyl, C4 to about C6 heterocycloalkyl, C1 to about C6 alkyl, C2 to about C6 alkene, a 6-membered aryl, and a 6-numbered heteroaryl; (2) R2 is hydrogen; (3) R3 is selected from hydrogen and hydroxy; (4) R5 is selected from hydrogen, hydroxy, amino, halo, C1 to about C6 alkyl, C2 to about C6 alkene, and C1 to about C6 alkoxy; (5) R6 is selected from hydrogen, hydroxy, aminocarbonyl, cyano, C1 to about C4 alkyl, an C2 to about C4 alkene; all such alkyl and alkene moieties being unsubstituted or substituted with from 1 to about 3 fluoro, or in the case of methyl or ethyl, optionally substituted with one hydroxy or one amino moiety; (6) R7 is selected from â€ƒwherein (a) R9 is (i) amino which is attached to a ring carbon of R7 which is not adjacent to the ring nitrogen of R7, the amino being unsubstituted or substituted with one or two C1 to about C3 alkyl; or (ii) aminoalkyl which is attached to any ring carbon of R7 and is C1 to about C3 alkyl substituted with one amino, the amino being unsubstituted or substituted with one or two C1 to about C3 alkyl; and (b) R10 represents the moieties on R7 other than R9 and each R10 is independently selected from hydrogen, C1 to about C4 alkyl, C2 to about C6 alkene, and a C3 to about C6 fused or spirocycle alkyl ring; all alkyl, alkene and cycle R10 moieties being unsubstituted or substituted with one hydroxy or with from 1 to about 3 fluoro moieties; and (7) R8 is selected from halo, C1 to about C6 alkoxy, C1 to about C6 alkylthio, C1 to about C6 alkyl and C2 to about C6 alkene; or an optical isomer, diastereomer or enantiomer thereof; or a phanmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.