Patent ID: 7074412
Filing Date: 2006-07-11
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising a bone morphogenetic protein and a pyrrolidone in a pharmaceutically acceptable carrier, wherein said bone morphogenetic protein and said pyrrolidone are present in an amount at or adjacent to a site of administration of the pharmaceutical composition and at the time of administration sufficient to provide a synergistic therapeutic effect on bone formation, wherein said bone morphogenetic protein is selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6 and BMP-7, and wherein said pyrrolidone is selected from the group consisting of 1-methyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, 2-pyrrolidone and 1-cyclohexyl-2-pyrrolidone.