Patent ID: 6608227
Filing Date: 2003-08-19
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein:A is selected from G is selected from â€”C(O)NR2R3 and â€”C(&boxH;S)NR2R3; R1 and R2 are independently selected from H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 Ra; Ra, at each occurrence, is selected from C1-4 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNRbRb, (CH2)rOH, (CH2)rORc, (CH2)rSH, (CH2)rSRc, (CH2)rC(O)Rb, (CH2)rC(O)NRbRb, (CH2)rNRbC(O)Rb, (CH2)rC(O)ORb, (CH2)rOC(O)Rc, (CH2)rCH(&boxH;NRb)NRbRb, (CH2)rNHC(&boxH;NRb)NRbRb, (CH2)rS(O)pRc, (CH2)rS(O)2NRbRb, (CH2)rNRbS(O)2Rc, and (CH2)rphenyl; Rb, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; Rc, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl; R3 is selected from a (CR3â€²R3â€³)râ€”C3-10 carbocyclic residue substituted with 0-5 R15 and a (CR3â€²R3â€³)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15; R3â€² and R3â€³, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; R4 is hydrogen, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 Ra; alternatively, R4 joins with R8 or R11 to form a pyrrolidine or piperidine ring system substituted with 0-3 R4d; R4â€² is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, C2-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)qC(O)R4b, (CH2)qC(O)NR4aR4aâ€², (CH2)qC(O)OR4a, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R4c; R4a and R4aâ€², at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; R4b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, (CH2)rC3-6 cycloalkyl, C2-8 alkynyl, and phenyl; R4c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rNR4aR4aâ€², and (CH2)rphenyl; R4d, is selected from H, C1-6 alkyl, (CHRâ€²)qOH, (CHRâ€²)qOR7a, (CHRâ€²)qOC(O)R7b, (CHRâ€²)qOC(O)NHR7a; R5 is selected from a (CR5â€²R5â€³)tâ€”C3-10 carbocyclic residue substituted with 0-5 R16 and a (CR5â€²R5â€³)t-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16; R5â€² and R5â€³, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; R7, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CHRâ€²)qOH, (CHRâ€²)qSH, (CHRâ€²)qOR7d, (CHRâ€²)qSR7d, (CHRâ€²)qNR7aR7aâ€², (CHRâ€²)qC(O)OH, (CHRâ€²)rC(O)R7b, (CHRâ€²)qC(O)NR7aR7aâ€², (CHRâ€²)qNR7aC(O)R7a, (CHRâ€²)qNR7aC(O)H, (CHRâ€²)qC(O)OR7a, (CHRâ€²)qOC(O)R7b, (CHRâ€²)qS(O)pR7b, (CHRâ€²)qS(O)2NR7aR7aâ€², (CHRâ€²)qNR7aS(O)2R7b, (CHRâ€²)qNHC(O)NR7aâ€²R7a, (CHRâ€²)qNHC(O)OR7a, (CHRâ€²)qOC(O)NHR7a, C1-6 haloalkyl, and a (CHRâ€²)râ€”C3-10 carbocyclic residue substituted with 0-3 R7c; R7a and R7aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R7e; R7b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, and a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R7e; R7c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR7fR7f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R7b, (CH2)rC(O)NR7fR7f, (CH2)rNR7fC(O)R7a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R7b, (CH2)rC(&boxH;NR7f)NR7fR7f, (CH2)rS(O)pR7b, (CH2)rNHC(&boxH;NR7f)NR7fR7f, (CH2)rS(O)2NR7fR7f, (CH2)rNR7fS(O)2R7b, and (CH2)rphenyl substituted with 0-3 R7e; R7d, at each occurrence, is selected from methyl, CF3, C2-6 alkyl substituted with 0-3 R7e, and a C3-10 carbocyclic residue substituted with 0-3 R7c; R7e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)qOH, OH, (CH2)qSH, SH, (CH2)rSC1-5 alkyl, (CH2)qNR7fR7f, and (CH2)rphenyl; R7f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R8 is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)rphenyl substituted with 0-3 R8a; R8a, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR7fR7f, and (CH2)rphenyl; alternatively, R7 and R8 join to form C3-7 cycloalkyl, or &boxH;NR8b; R8b is selected from H, C1-6 alkyl, C3-6 cycloalkyl, OH, CN, and (CH2)r-phenyl; R11, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)qOH, (CH2)qSH, (CH2)qOR11d, (CH2)qSR11d, (CH2)qNR11aR11aâ€², (CH2)rC(O)OH, (CH2)rC(O)R11b, (CH2)rC(O)NR11aR11aâ€², (CH2)qNR11aC(O)R11b, (CH2)qNR11aC(O)NR11aâ€²R11a, (CH2)rC(O)OR11a, (CH2)qOC(O)R11b, (CH2)qS(O)pR11b, (CH2)qS(O)2NR11aR11aâ€², (CH2)qNR11aS(O)2R11b, C1-6 haloalkyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R11c; R11a and R11aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R11e; R11b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, and a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R11e; R11c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR11fR11f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R11b, (CH2)rC(O)NR11fR11f, (CH2)rNR11fC(O)R11a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R11b, (CH2)rC(&boxH;NR11f)NR11fR11f, (CH2)rNHC(&boxH;NR11f)NR11fR11f, (CH2)rS(O)pR11b, (CH2)rS(O)2NR11fR11f, (CH2)rNR11fS(O)2R11b, and (CH2)rphenyl substituted with 0-3 R11e; R11d, at each occurrence, is selected from methyl, CF3, C2-6 alkyl substituted with 0-3 R11e, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R11c; R11e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR11fR11f, and (CH2)rphenyl; R11f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R15, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHRâ€²)rNR15aR15aâ€², (CHRâ€²)rOH, (CHRâ€²)rO(CHRâ€²)rR15d, (CHRâ€²)rSH, (CHRâ€²)rC(O)H, (CHRâ€²)rS(CHRâ€²)rR15d, (CHRâ€²)rC(O)OH, (CHRâ€²)rC(O)(CHRâ€²)rR15b, (CHRâ€²)rC(O)NR15aR15aâ€², (CHRâ€²)rNR15fC(O)(CHRâ€²)rR15b, (CHRâ€²)rNR15fC(O)NR15aR15aâ€², (CHRâ€²)rC(O)O(CHRâ€²)rR15d, (CHRâ€²)rOC(O)(CHRâ€²)rR15b, (CHRâ€²)rC(&boxH;NR15f)NR15aR15aâ€², (CHRâ€²)rNHC(&boxH;NR15f)NR15aR15aâ€², (CHRâ€²)rS(O)p(CHRâ€²)rR15b, (CHRâ€²)rS(O)2NR15aR15aâ€², (CHRâ€²)rNR15fS(O)2(CHRâ€²)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 Râ€², C2-8 alkynyl substituted with 0-3 Râ€², (CHRâ€²)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; Râ€², at each occurrence, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e; R15a and R15aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; R15b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-3 R15e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; R15d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R15e, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R15e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e; R15e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, and (CH2)rphenyl; R15f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; R16, at each occurrence, is selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHRâ€²)rNR16aR16aâ€², (CHRâ€²)rOH, (CHRâ€²)rO(CHRâ€²)rR16d, (CHRâ€²)rSH, (CHRâ€²)rC(O)H, (CHRâ€²)rS(CHRâ€²)rR16d, (CHRâ€²)rC(O)OH, (CHRâ€²)rC(O)(CHRâ€²)rR16b, (CHRâ€²)rC(O)NR16aR16aâ€², (CHRâ€²)rNR16fC(O)(CHRâ€²)rR16b, (CHRâ€²)rC(O)O(CHRâ€²)rR16d, (CHRâ€²)rOC(O)(CHRâ€²)rR16b, (CHRâ€²)rC(&boxH;NR16f)NR16aR16aâ€², (CHRâ€²)rNHC(&boxH;NR16f)NR16aR16aâ€², (CHRâ€²)rS(O)p(CHRâ€²)rR16b, (CHRâ€²)rS(O)2NR16aR16aâ€², (CHRâ€²)rNR16fS(O)2(CHRâ€²)rR16b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 Râ€², C2-8 alkynyl substituted with 0-3 Râ€², and (CHRâ€²)rphenyl substituted with 0-3 R16e; R16a and R16aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R16e; R16b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, and a (CH2)rC3-6 carbocyclic residue substituted with 0-3 R16e; R16d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R16e, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R16e; R16e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR16fR16f, and (CH2)rphenyl; R16f, at each occurrence, is selected from H, C1-5 alkyl, and C3-6 cycloalkyl, and phenyl; R17, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)qOH, (CH2)qSH, (CH2)qOR17d, (CH2)qSR17d, (CH2)qNR17aR17aâ€², (CH2)rC(O)OH, (CH2)rC(O)R17b, (CH2)rC(O)NR17aR17aâ€², (CH2)qNR17aC(O)R17b, (CH2)qNR17aC(O)H, (CH2)rC(O)OR17a, (CH2)qOC(O)R17b, (CH2)qS(O)pR17b, (CH2)qS(O)2NR17aR17aâ€², (CH2)qNR17aS(O)2R17b, C1-6 haloalkyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R17c; R17a and R17aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R17e; R17b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, and a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R17e; R17c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR17fR17f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R17b, (CH2)rC(O)NR17fR17f, (CH2)rNR17fC(O)R17a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R17b, (CH2)rC(&boxH;NR17f)NR17fR17f, (CH2)rS(O)pR17b, (CH2)rNHC(&boxH;NR17f)NR17fR17f, (CH2)rS(O)2NR17fR17f, (CH2)rNR17fS(O)2R17b, and (CH2)rphenyl substituted with 0-3 R17e; R17d, at each occurrence, is selected from methyl, CF3, C2-6 alkyl substituted with 0-3 R17e, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R17c; R17e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR17fR17f, and (CH2)rphenyl; R17f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R18, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CHRâ€²)qOH, (CHRâ€²)qSH, (CHRâ€²)qOR18d, (CHRâ€²)qSR18d, (CHRâ€²)qNR18aR18aâ€², (CHRâ€²)rC(O)OH, (CHRâ€²)rC(O)R18b, (CHRâ€²)rC(O)NR18aR18aâ€², (CHRâ€²)qNR18aC(O)R18a, (CHRâ€²)qNR18aC(O)H, (CHRâ€²)rC(O)OR18a, (CHRâ€²)qOC(O)R18b, (CHRâ€²)qS(O)pR18b, (CHRâ€²)qS(O)2NR18aR18aâ€², (CHRâ€²)qNR18aS(O)2R18b, C1-6 haloalkyl, and a (CHRâ€²)râ€”C3-10 carbocyclic residue substituted with 0-3 R18c; R18a and R18aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R18e; R18b, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, and a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R18e; R18c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR18fR18f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R18b, (CH2)rC(O)NR18fR18f, (CH2)rNR18fC(O)R18a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R18b, (CH2)rC (&boxH;NR18f)NR18fR18f, (CH2)rS(O)pR18b, (CH2)rNHC(&boxH;NR18f)NR18fR18f, (CH2)rS(O)2NR18fR18f, (CH2)rNR18fS(O)2R18b, and (CH2)rphenyl substituted with 0-3 R18e; R18d, at each occurrence, is selected from methyl, CF3, C2-6 alkyl substituted with 0-3 R18e, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R18c; R18e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR18fR18f, and (CH2)rphenyl; R18f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; m, at each occurrence, is selected from 1, 2, 3, 4, and 5; n, at each occurrence, is selected from 0, 1, 2, 3, 4, and 5; o, at each occurrence, is selected from 1 and 2; p, at each occurrence, is selected from 1 and 2; r, at each occurrence, is selected from 0, 1, 2, 3, 4, and 5; q, at each occurrence, is selected from 1, 2, 3, 4, and 5; t, at each occurrence, is selected from 0, 1, 2, 3, 4, and 5; u, at each occurrence, is independently selected from 0, 1, and 2; v, at each occurrence, is selected from 0 and 1; and w, at each occurrence, is selected from 0, 1, 2, and 3.