Patent ID: 8945512
Filing Date: 2015-02-03
Classification: A61K

Abstract:
1. A method of imaging a subject comprising, administering to the subject a paramagnetic CEST agent comprising, a substrate molecule (SH) comprising at least one mobile proton in exchange with bulk water bound by electrostatic interactions having a thermodynamic constant of association Ka greater than 10 to a paramagnetic chelate complex (SR) of a metal ion selected from the group consisting of: iron (II) (high-spin configuration), iron (III), cobalt (II), rhodium (II), copper (II), nickel (II), cerium (III), praseodymium (III), neodymium (III), dysprosium (III), erbium (III), terbium (III), holmium (III), thulium (III), ytterbium (III) and europium (III); applying an if pulse sufficient to saturate the resonance of the at least one mobile proton shifted from the bulk water as a result of said electrostatic interaction to create a saturated magnetization that is transferred to the bulk water through chemical exchange, and imaging the subject using a CEST-based MRI procedure.