Patent ID: 8633296
Filing Date: 2014-01-21
Classification: A61K,C08G,C08J

Abstract:
1. A composite hydrogel, comprising: an amphiphilic triblock copolymer (ABA), wherein i) the triblock copolymer comprises two independent peripheral hydrophobic A blocks and a hydrophilic central B block, ii) each of the A blocks comprises a steroidal repeat unit (repeat unit 1) comprising both a backbone carbonate and a side chain comprising a steroid functional group, iii) each of the A blocks has a degree of polymerization of about 0.5 to about 4.0, and iv) the B block comprises a first poly(alkylene oxide) backbone; and a loaded micelle comprising a biologically active substance and an amphiphilic diblock copolymer (CD), wherein i) the diblock copolymer comprises a hydrophilic C block and a hydrophobic D block, ii) the C block comprises a second poly(alkylene oxide) backbone, and iii) the D block comprises a steroidal repeat unit (repeat unit 2) comprising both a backbone carbonate group and a side chain comprising a steroid functional group; wherein the amphiphilic triblock copolymer and the loaded micelle are bound by noncovalent interactions, and the composite hydrogel is capable of controlled release of a biologically active substance.