Patent ID: 6498276
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A production method of an acetophenone compound of the formula [5]wherein R1 is an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group, R2 is a lower alkyl or a halogenated lower alkyl and R3 is a halogen atom or a hydrogen atom, comprising reacting a compound of the formula [1]wherein R1 and R2 are as defined above, with thionyl chloride in an inert solvent in the presence of a base to give an oxazolone compound of the formula [2]wherein R1 and R2 are as defined above, sequentially reacting this compound with a compound of the formula [3]wherein R3 is as defined above and X is a halogen atom, in ethyl acetate in the presence of a magnesium salt and a base to give a compound of the formula [4]wherein R1, R2 and R3 are as defined above, and subjecting this compound to hydrolysis and decarboxylation with an acid.