Patent ID: 6303625
Filing Date: 2001-10-16
Classification: A61P,C07D

Abstract:
A compound of the formula selected from the group consisting of (I) and (II): ##STR22##wherein M is (CH.sub.2).sub.m, CH.dbd.CH, CH.dbd.CF, CF.dbd.CH, or C.ident.C;n is an integer selected from the group consisting of 0, 1 and 2;A is selected from the group consisting of piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, NHR.sub.2 and ##STR23##wherein R is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl, CH.dbd.(NH), CMe.dbd.(NH), C.sub.2 -C.sub.6 acyl, C.sub.1 -C.sub.8 alkoxycarbonyl and ar(C.sub.1 -C.sub.8 alkoxy)carbonyl;R.sub.2 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl and C.sub.2 -C.sub.6 acyl;R.sub.10 is selected from the group consisting of hydrogen and C(O)N(R.sub.1)YZ, wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl and C.sub.3 -C.sub.8 cycloalkyl;Y is selected from the group consisting of (CH.sub.2).sub.p, CH(R.sub.3)(CH.sub.2).sub.q, (CH.sub.2).sub.q CH(R.sub.3), (CH(CO.sub.2 R.sub.4)CH.sub.2).sub.q, (CH.sub.2).sub.q CHOH and piperidine-3-carboxylic acid;R.sub.3 is selected from the group consisting of C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, aryl, ar(C.sub.1 -C.sub.8)alkyl and heteroaryl; p1 R.sub.4 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl and C.sub.3 -C.sub.8 cycloalkyl;p is an integer selected from the group consisting of 2 and 3;q is an integer selected from the group consisting of 1, 2, and 3;Z is CO.sub.2 R.sub.8 ;R.sub.5 is C(O)NHQ(CHW).sub.r CO.sub.2 R.sub.8 ;wherein Q is selected from the group consisting of CH.sub.2, CH-aryl, CH-heteroaryl, CH-substituted-heteroaryl and CH-(C.sub.1 -C.sub.8)alkyl;W is selected from the group consisting of hydrogen and N(R.sub.6)T-R.sub.7 ;R.sub.6 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl and C.sub.2 -C.sub.6 acyl;T is selected from the group consisting of C(O), C(N--CN) and SO.sub.2 ;R.sub.7 is selected from the group consisting of C.sub.1 -C.sub.8 alkyl, aryl, ar(C.sub.1 -C.sub.8)alkyl, ar(C.sub.1 -C.sub.8)alkoxy, C.sub.1 -C.sub.8 alkoxy, (C.sub.1 -C.sub.8)alkylamino, unsubstituted heteroaryl(C.sub.0 -C.sub.8)alkyl and substituted heteroaryl(C.sub.0 -C.sub.8)alkyl; andR.sub.8 is hydrogen, C.sub.1 -C.sub.8 alkyl, or CH.sub.2 C(O)NR.sub.11 R.sub.12 ; wherein R.sub.11 and R.sub.12 are each independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl, and C.sub.3 -C.sub.8 cycloalkyl;m is an integer selected from the group consisting of 1, 2, and 3;r is an integer selected from the group consisting of 0 and 1; andR.sub.15 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.8 alkyl;and pharmaceutically acceptable salts thereof.