Patent ID: 8974814
Filing Date: 2015-03-10
Classification: A61K,A61P

Abstract:
1. A layered polymeric drug delivery system comprising: an elongated monofilament fiber body having a length and a cross-sectional profile, the cross-sectional profile having a perimeter; wherein the elongated monofilament fiber body comprises a plurality of connected segments disposed along a longitudinal axis of the monofilament fiber body, each of said segments formed of at least two simultaneously coagulated and coextruded polymeric layers, the polymeric layers being formed from polymeric materials extrudable in one or more compatible non-solvents, wherein: the at least two coextruded polymeric layers are bound by polymer fusion at their interface, said interface between the at least two polymeric layers extending in a direction along the longitudinal axis of the monofilament fiber body; at least a portion of each of the at least two polymeric layers defines at least a portion of the perimeter of the monofilament fiber body; at least one therapeutic agent is disposed or contained within at least one of the at least two polymeric layers of at least one segment, said at least one therapeutic agent having a release rate at which the therapeutic agent is released from the layered polymeric drug delivery system into a subject; and each of the polymeric layers of the layered polymeric drug delivery system being defined by a dissolution rate at which the polymeric layer is dissolved, wherein the dissolution rate of a least one of the polymeric layers is slower that the release rate of all of the therapeutic agents such that the therapeutic agent delivery and structural integrity of the layered polymeric drug delivery system are distinct; and wherein the monofilament fiber body further comprises a plurality of connected segments disposed along the longitudinal axis of the monofilament fiber body.