Patent ID: 7381738
Filing Date: 2008-06-03
Classification: C07D

Abstract:
1. A compound of formula (I): or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: X is O; Z is selected from a bond, —C(O)—, —C(O)NR R R R R R alternatively, two R R R R R R R alternatively, two R R alternatively, two R R alternatively, two R R R R alternatively, two R R alternatively, two R R alternatively, two R R R R R alternatively, two R R R′, at each occurrence, is independently, selected from H, methyl, and C alternatively, two R′s, along with the carbon atom to which they are attached, join to form a cyclopropyl ring; R R R R alternatively, two R R R alternatively, two R R alternatively, two R R alternatively, two R R a is selected from 0 and 1; b is selected from 0, 1, 2 and 3; with the proviso that a+b is selected from 1, 2 and 3; c is 1; d is 1; with the proviso that c+d is 2; n is selected from 1 and 2; p, at each occurrence, is independently selected from 0, 1, and 2; q, at each occurrence, is independently selected from 1, 2, 3, and 4; r, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and u is selected from 1, 2 and 3.