Patent ID: 6124438
Filing Date: 2000-09-26
Classification: A61K,C07K,G01N

Abstract:
A receptor that specifically binds to brain cell tissue comprising an isolated and purified antibody or epitope-binding portion thereof raised to a synthetic polypeptide about 10 to about 50 amino acid residues in length or a conjugate of that synthetic polypeptide bound to a carrier, said synthetic polypeptide having(a) a determined amino acid residue sequence substantially corresponding to an amino acid residue sequence of at least a portion of a naturally occurring proteinoid, and(b) a molecular weight equal to less than that of said proteinoid,said proteinoid containing an amino acid residue sequence that is translated from a cytoplasmic messenger RNA present in brain cells but not in the cells of the liver, kidney, gut, lung, heart, or skeletal muscle of the same species of mammal, said receptor binding specifically to said synthetic polypeptide and to said proteinoid when admixed with brain cell tissue including said naturally occurring proteinoid.