Patent ID: 7098219
Filing Date: 2006-08-29
Classification: A61K,C07D

Abstract:
1. An efflux pump inhibitor compound selected from the group consisting of Isopropyl 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4′-amino-3′,3′-dimethyl-piperidin-1-yl}-4-oxo-quinoline-3-carboxylate; n-Butyl 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4′-amino-3′,3′-dimethyl-piperidin-1-yl}-4-oxo-quinoline-3-carboxylate; Benzyl-1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4′-(t-butoxycarbonyl amino)-3′,3′-dimethyl-piperidin-1-yl}-4-oxo-quinoline-3-carboxylate; (R)-(+)-Ethoxycarbonylmethyl-9-fluoro-6,7-dihydro-8-(4′-hydroxypiperidin-1′-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylate; (S)-(−)-N-Methylpiperidin-1-yl-9-fluoro-6,7-dihydro-8-(4′-hydroxypiperidin-1′-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylate; (S)-(−)-N-Morpholinoethyl-1-yl-9-fluoro-6,7-dihydro-8-(4′-hydroxypiperidin-1′-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylate; (S)-(−)-9-Fluoro-6,7-dihydro-8-(4′-L-alaninyloxy-piperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid hydrochloride; (S)-(−)-9-Fluoro-6,7-dihydro-8-(4′-D-leucyloxy-piperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid hydrochloride and (RS)-(±)-9-Fluoro-6,7-dihydro-8-(4′-D-phenylalaninyloxy-piperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid hydrochloride.