Patent ID: 8618270
Filing Date: 2013-12-31
Classification: A61P,C12N

Abstract:
1. An anti-flaviviral compound composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of the adjacent subunit, and characterized by: (i) a nuclease-resistant backbone, (ii) capable of uptake by virus-infected animal cells, (iii) containing between 11-40 nucleotide bases, (iv) comprising a sequence of 11 contiguous bases complementary to the sequence identified as SEQ ID NO:4, and (v) capable of forming with a flavivirus ssRNA genome containing SEQ ID NO:4, a heteroduplex structure characterized by a temperature of dissociation of at least 45° C.