Patent ID: 6224849
Filing Date: 2001-05-01
Classification: A61P,C07B,C07D

Abstract:
A compound of the formula (I) ##STR19##a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, whereinX is O or S;n is 2, 3, 4 or 5;R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy or halo;R.sup.2 is hydrogen, C.sub.1-6 alkyl, phenyl, phenylC.sub.1-6 alkyl or phenylcarbonyl;R.sup.3 and R.sup.4 each independently are selected from hydrogen, halo, nitro, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, haloC.sub.1-6 alkyl, aminosulfonyl, mono- or di(C.sub.1-4 alkyl)aminosulfonyl; orR.sup.3 and R.sup.4 may also be taken together to form a bivalent radical of formula --CH.dbd.CH--CH.dbd.CH--, wherein the compound has at least one halo which is a radioactive isotope of iodine, bromine or fluorine, or having at least one .sup.11 C-atom or tritium atom.