Patent ID: 8835509
Filing Date: 2014-09-16
Classification: A61K,A61P

Abstract:
1. A self-emulsifying drug delivery system for a pharmaceutical composition, said system comprising, a pharmaceutically effective amount of curcuminoid present in a range of 1-10% (w/w); an oil phase wherein said oil phase is propylene glycol monocaprylate present in a range of 25-33% (w/w); a surfactant, wherein said surfactant is a polyoxyethylene or polyethoxyl derivative of a vegetable oil present in a range of 35-45% (w/w); one or more co-surfactant(s) present in a range of 8-16% (w/w), wherein said co surfactant(s) is/are different from said surfactant; further wherein said composition is substantially free of polymeric molecular aggregation inhibitor; further wherein said pharmaceutical composition spontaneously forms a nano emulsion when brought in contact with an aqueous fluid of human gastrointestinal tract; further wherein said composition at 40° C./75 relative humidity is stable for at least 6 months; further wherein said composition has drug loading capability of more than 3%; and further wherein said composition has at least 8 fold increase in Cmax and at least 4 fold increase in AUC as compared to curcuminoid aqueous suspension.