Patent ID: 8329645
Filing Date: 2012-12-11
Classification: A61K,A61P,C07K

Abstract:
1. A polymyxin derivative of formula: wherein A is a polymyxin ring moiety, wherein the polymyxin ring moiety has a formula of wherein R R R R4 is Glu, Asp, Dab, diaminopropionic acid, Thr, Ser or Cys; R5 is Dab or Abu; R6 is D-Phe or D-Leu; R7 is Leu, Thr or Ile; R8 is Dab or Abu; R9 is Dab or Abu; R10 is Thr or Leu; m m D is selected from R wherein said polymyxin derivative has at least two but no more than three positive charges at physiological pH.