Patent ID: 6303600
Filing Date: 2001-10-16
Classification: A61P,C07D

Abstract:
A compound of the general formula (I): ##STR167##wherein##STR168##represents a bicyclic ring system, of 9 ring members, in which the ring ##STR169##is an azaheterocycle, selected from imidazolyl, pyrrolyl, pyrrolinyl and pyrazolyl, and the ring ##STR170##represents a benzene ring;R.sup.1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms;R.sup.2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, --SO.sub.2 NR.sup.4 R.sup.5, --NR.sup.4 SO.sub.2 R.sup.5, --NR.sup.4 R.sup.5, --C(.dbd.O)R.sup.5, --C(.dbd.O)C(.dbd.O)R.sup.5, --C(.dbd.O)NR.sup.4 R.sup.5, --C(.dbd.O)OR.sup.5, --O(C.dbd.O)NR.sup.4 R.sup.5, or --NR.sup.4 C(.dbd.O)R.sup.5 ;R.sup.3 represents --C(.dbd.O)NHR.sup.6, --C(.dbd.O)CH.sub.2 R.sup.6 or --OCH.sub.2 R.sup.6 ;R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom, or an alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, or heteroarylalkyl group;R.sup.6 is optionally substituted pyridyl or isoxazolyl;A.sup.1 represents a direct bond, or a straight or branched C.sub.1-6 alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A.sup.1 represents a straight or branched C.sub.2-6 alkenylene or C.sub.2-6 alkynylene chain;Z.sup.1 represents a direct bond, an oxygen or sulphur atom or NH;n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1;provided further that, when ##STR171##is an indole ring, R.sup.1 and R.sup.2 are both hydrogen atoms, Z.sup.1 and A.sup.1 are both direct bonds and R.sup.3 is --OCH.sub.2 R.sup.6 attached to the 6-position of the indole ring, then R.sup.6 is not 3-pyridyl;and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs.