Patent ID: 6872806
Filing Date: 2005-03-29
Classification: C07K

Abstract:
1. A coiled-coil polypeptide comprising the formula (ab i c i de i f i g i ) n , where i=1, 2, . . . , n, and n is at least three, said polypeptide being prepared by (a) selecting a solvent-accessible region of an epitope of a selected natural protein, wherein said region is not in a coiled-coil conformation in its native state, and inserting the amino acids from said region into the b (b) independently inserting an amino acid selected from the group consisting of leucine, isoleucine, valine, phenylalanine, methionine, tyrosine, and derivatives thereof, into each of the a and d positions such that the amino acids from the epitope in the b wherein (ab