Patent ID: 6291530
Filing Date: 2001-09-18
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula ##STR19##or of the formula ##STR20##wherein in formula II the substituents --X--Y--Z and --X.sup.1 --R are located at the meta (3) and para (4) positions or at the two meta (3 and 3') positions and wherein in formula III the said substituents are at adjacent 5 and 6 positions of the pyridine ring;R is (mono or di-carbocyclic or heterocyclic aryl)-lower alkyl;R.sup.1 is hydrogen or lower alkyl;R.sup.2 and R.sup.3 are hydrogen, lower alkyl, lower alkoxy-lower alkyl or aryl-lower alkyl;or R.sup.2 and R.sup.3 together with the nitrogen to which they are attached represent pyrrolidino, piperidino, or morpholino;X is O, S or a direct bond;X.sup.1 is O, S or a direct bond;Y is a direct bond, lower alkylene or lower alkylidene; andZ is carboxyl, 5-tetrazolyl, hydroxymethyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; or a pharmaceutically acceptable salt thereof.