Patent ID: 6335195
Filing Date: 2002-01-01
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of accelerating the proliferation of hematopoietic lineage-specific cells comprising contacting the cells with an amount effective to accelerate proliferation of the cells of at least one active agent comprising a sequence of at least seven contiguous amino acids of groups R1-R8 in the sequence of general formula IR1â€”R2â€”R3â€”R4â€”R5â€”R6â€”R7âˆ’R8 in which R1 and R2 together form a group of formulaâ€ƒXâ€”RAâ€”RBâ€”,wherein X is H or a one to three peptide group, or is absent; RA is selected from the group consisting of Asp, Glu, Asn, Acpc (1-aminocyclopentane carboxylic acid), Ala, Me2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2) and Suc, or RA is absent, RB is selected from the group consisting of Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys; R3 is selected from the group consisting of Val, Ala, Leu, norLeu, Ile, Gly, Pro, Aib, Acpc and Tyr; R4 is selected from the group consisting of Tyr, Tyr(PO3)2, Thr, Ser, homoSer and azaTyr; R5 is selected from the group consisting of Ile, Ala, Leu, norLeu, Val and Gly; R6 is His, Arg or 6-NH2-Phe; R7 is Pro or Ala; and R8 is selected from the group consisting of Phe, Phe(Br), Ile, Tyr, or is absent, wherein the compound is not SEQ ID NO:1.