Patent ID: 6111132
Filing Date: 2000-08-29
Classification: A61P,C07B,C07C,C07D

Abstract:
A compound of the formula (I): ##STR22## wherein: R.sup.1 is H, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;R is H, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is H, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is H, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 Ph and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 Ph and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.3, R.sup.2 is -(cyclohexyl) and R.sup.3 is H;R.sup.1 is --CH.sub.3, R.sup.2 is -(cyclohexyl) and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 (cyclopropyl) and R.sup.3 is H;R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 (cyclopropyl) and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is H;R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is H;R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- and R.sup.3 is H; orR.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;and salts, solvates and resolved enantiomers thereof.