Patent ID: 6040297
Filing Date: 2000-03-21
Classification: A61P,C07H

Abstract:
A dinucleoside-5',5'-P.sup.1,P.sup.2 -pyrophosphate of the formula (I): ##STR48## wherein: the symbols A and B each independently represent a 5'-C' radical of a non-naturally occurring nucleoside selected from 1-thyminyl-3-azido-2,3-dideoxy-D-riboside and 1-uracilyl-3-azido-2,3-dideoxy-D-riboside;the symbols X each independently represent oxygen or sulfur;the symbols R and R.sub.1 each independently represent hydrogen or an alkyl group of from 1 to 10 carbon atoms, which may optionally contain an unsaturation and/or one or two substituents selected from hydroxy, mercapto, chloro, iodo, fluoro, bromo, amino, (C.sub.1 -C.sub.4)alkylamino, di-(C.sub.1 -C.sub.4)alkylamino, (C.sub.1 -C.sub.4)alkoxy and (C.sub.1 -C.sub.4)alkylthio;and the addition salts of the compounds of formula (I) wherein R and/or R.sub.1 represent hydrogen with bases providing biologically acceptable cations.