Patent ID: 9109256
Filing Date: 2015-08-18
Classification: A61B,C12Q,Y10T

Abstract:
1. A method for monitoring disappearance, regression, progression or recurrence of diseased tissue in a patient, the method comprising the steps of: obtaining a first heterogeneous biological sample from the patient; generating a patient-specific genetic profile of diseased tissue by interrogating a plurality of genomic loci in genomic DNA and/or free DNA isolated from the first heterogeneous biological sample obtained from the patient for the presence and/or the amount of a plurality of biomarkers, wherein initiating a treatment protocol after the first heterogeneous biological sample is obtained; obtaining a second heterogeneous biological sample from said patient after treatment; and monitoring the patient-specific genetic profile by interrogating the plurality of genomic loci in genomic DNA and/or free DNA isolated from the second heterogeneous biological sample for the presence and/or the amount of the plurality of biomarkers, wherein a change of the patient-specific genetic profile is indicative of the disappearance, regression, progression or recurrence of the diseased tissue in the patient.