Patent ID: 6451804
Filing Date: 2002-09-17
Classification: A61P,C07D

Abstract:
A compound selected from the group of compounds represented by formula I: whereinthe subscript n is an integer of from 0 to 3; R1 is acyl, heteroalkyl, arylheteroalkyl, heteroalkenyl, heteroalkynyl, heteroalkylcarbonyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkylalkyl, heterosubstituted cycloalkylalkenyl, heterosubstituted cycloalkylalkynyl, heteroalkylsubstituted cycloalkyl, heterocyclyl, heterocyclylalkyl, heterocyclyl spiro cycloalkyl, -(alkylene)â€”C(O)â€”R11, or -(heteroalkylene)â€”C(O)â€”R11; wherein: R11 is alkyl, haloalkyl, amino, monosubstituted amino, disubstituted amino, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, hydroxy, or alkoxy; R2 is independently in each occurrence alkyl, halo, heteroalkyl, or vinyl; R3 is hydrogen, alkyl, heteroalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, haloalkyl, cyanoalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterocyclyl, heterocyclylalkyl, -(alkylene)â€”C(O)R31, or -(heteroalkylene)â€”C(O)R31; and R4 is hydrogen, alkyl, or -(alkylene)â€”C(O)R31; wherein: R31 is alkyl, haloalkyl, hydroxy, alkoxy, amino, monsubstituted amino, disubstituted amino, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or an individual isomer, a racemic or nonracemic mixture of isomers, or a pharmaceutically acceptable salt thereof.