Patent ID: 8278317
Filing Date: 2012-10-02
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: N,N-diisopropyl-3-phenyl-4-[(4-phenylbutanoyl)amino]-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[({[(1S)-1-phenylethyl]amino}carbonyl)amino]-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[(3-phenylpropanoyl)amino]-2-pyridin-3-ylbutanamide, 4-{([3-(2-fluorophenyl)propanoyl]amino}-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[(3-phenylbutanoyl)amino]-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-({[(3-methylbenzyl)amino]carbonyl}amino)-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(4-bromobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(4-fluorobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[({[(1R,2S)-2-phenylcyclopropyl]amino}carbonyl)amino]-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-[({[1-(1-naphthyl)ethyl]amino}carbonyl)amino]-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(3-fluorobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-[(benzylsulfonyl)amino]-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-({[(4-methylbenzyl)amino]carbonyl}amino)-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(2-fluorobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-{[(2-phenyl-1,3-thiazol-4-yl)acetyl]amino}-2-pyridin-3-ylbutanamide, 4-{[3-(2-chlorophenyl)propanoyl]amino}-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-({[(4-methoxybenzyl)amino]carbonyl}amino)-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-({[(E)-2-phenylvinyl]sulfonyl}amino)-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-2-pyridin-3-yl-4-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)butanamide, N,N-diisopropyl-3-phenyl-2-pyridin-3-yl-4-[(3-pyridin-2-ylpropanoyl)amino]butanamide, N,N-diisopropyl-3-phenyl-4-({[(2-phenylethyl)amino]carbonyl}amino)-2-pyridin-3-ylbutanamide, 4-({[(2-chlorobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-{[(cyclohexylamino)carbonyl]amino}-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(3-fluorophenyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-{[(1-naphthylamino)carbonyl]amino}-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[({[(1R)-1-phenylethyl]amino}carbonyl)amino]-2-pyridin-3-ylbutanamide, 4-({[(diphenylmethyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-4-[({[(1S)-1-phenylethyl]amino}carbonyl)amino]-2-pyridin-3-ylbutanamide, 4-{[(sec-butylamino)carbonyl]amino}-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-({[(diphenylmethyl)amino]carbonyl}amino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-[(2,3-dihydro-1H-inden-2-ylacetyl)amino]-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, 4-(acetylamino)-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-3-phenyl-2-pyridin-3-yl-4-({[2-(trifluoromethyl)phenyl]acetyl}amino)butanamide, 4-{[(2-chloro-6-fluorophenyl)acetyl]amino}-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N-[4-(diisopropylamino)-4-oxo-2-phenyl-3-pyridin-3-ylbutyl]pentanamide, N,N-diisopropyl-4-{[3-(1-methyl-1H-pyrazol-4-yl)propanoyl]amino}-3-phenyl-2-pyridin-3-ylbutanamide, methyl 5-{[2-(1,3-benzodioxol-5-yl)ethyl]amino}-5-oxo-3-phenyl-4-pyridin-3-ylpentanoate, N N N N N N N N N N N N methyl 5-{[5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-3-ylpentanoyl]amino}pentanoate, 1-tert-butyl 5-methyl 3-phenyl-2-pyridin-3-ylpentanedioate, methyl 4-(3-cyanophenyl)-5-(diisopropylamino)-5-oxo-3-pyridin-3-ylpentanoate, methyl 4-(3-bromophenyl)-5-(diisopropylamino)-5-oxo-3-pyridin-3-ylpentanoate, N N methyl 5-(diisopropylamino)-5-oxo-4-pyridin-3-yl-3-pyridin-4-ylpentanoate, 5-methoxy-5-oxo-3-phenyl-2-pyridin-3-ylpentanoic acid, methyl 5-(diisopropylamino)-5-oxo-4-pyridin-3-yl-3-pyridin-4-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-2-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-4-pyridin-2-yl-3-pyridin-4-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3,4-dipyridin-4-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-4-phenyl-3-pyridin-4-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-4-ylpentanoate, 3-(3-cyanophenyl)-4-({[(2-fluorobenzyl)amino]carbonyl}amino)-N,N-diisopropyl-2-pyridin-3-ylbutanamide, N-[4-(diisopropylamino)-4-oxo-2-phenyl-3-pyridin-3-ylbutyl]-2-fluoro-N-(methylsulfonyl)phenylalaninamide, N-[4-(diisopropylamino)-4-oxo-2-phenyl-3-pyridin-3-ylbutyl]-2-fluorophenylalaninamide, N-(tert-butoxycarbonyl)-N-[4-(diisopropylamino)-4-oxo-2-phenyl-3-pyridin-3-ylbutyl]-2-fluorophenylalaninamide, N,N-diisopropyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-(2-methyl-2H-tetrazol-5-yl)-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-(1-methyl-1H-tetrazol-5-yl)-3-phenyl-2-pyridin-3-ylbutanamide, 5-hydrazino-N,N-diisopropyl-5-oxo-3-phenyl-2-pyridin-3-ylpentanamide, N,N-diisopropyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-(5-methyl-1,3-oxazol-2-yl)-3-phenyl-2-pyridin-3-ylbutanamide, 4-cyano-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-[(methylsulfonyl)amino]-3-phenyl-2-pyridin-3-ylbutanamide, N,N-diisopropyl-4-(5-methyl-1,3-oxazol-2-yl)-3-phenyl-2-pyridin-3-ylbutanamide, 5-hydroxy-N,N-diisopropyl-3-phenyl-2-pyridin-3-ylpentanamide, tert-butyl 4-(diisopropylamino)-4-oxo-2-phenyl-3-pyridin-3-ylbutylcarbamate, methyl 3-(3-cyanophenyl)-5-(diisopropylamino)-5-oxo-4-pyridin-3-ylpentanoate, methyl 3-(3-bromophenyl)-5-(diisopropylamino)-5-oxo-4-pyridin-3-ylpentanoate, 5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-3-ylpentanoic acid, N methyl 5-(diisopropylamino)-5-oxo-4-phenyl-3-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-4-pyridin-2-yl-3-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-4-pyridin-2-yl-3-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-4-phenyl-3-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3,4-dipyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-3-(6-methoxypyridin-3-yl)-5-oxo-4-phenylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3-pyridin-2-yl-4-pyridin-4-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3-pyridin-2-yl-4-pyridin-3-ylpentanoate, methyl 5-(diisopropylamino)-5-oxo-3,4-dipyridin-2-ylpentanoate, and methyl 5-(diisopropylamino)-5-oxo-4-phenyl-3-pyridin-2-ylpentanoate, or a pharmaceutically acceptable salt thereof.