Patent ID: 6846803
Filing Date: 2005-01-25
Classification: A61K,C07K

Abstract:
1. An isolated antagonist of a ligand of the Corticotropin-Releasing Factor Receptor, type 2 (CRFR2) lacking the 8 to 10 N-terminal amino acids of native sauvagine and comprising the amino acid sequence, Xaa 1 -Xaa 2 -Leu—Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Gln—Gln-Ala-Ala-Asn-Asn-Arg-Leu—Leu—Leu-Asp-Thr-Ile-NH 2 , SEQ ID NO. 1 wherein Xaa 1 is a neutral amino acid, and Xaa 2 is a charged amino acid.