Patent ID: 6589778
Filing Date: 2003-07-08
Classification: B01J,B01L,C07B,C40B

Abstract:
An apparatus for performing biological reactions, comprising:(a) a glass microscope slide having a first surface and a second surface opposite thereto; (b) an array of biomolecules positioned on the first surface of the slide, wherein each biomolecule within the array is anchored to the first surface by a polyacrylamide gel pad; (c) a layer of polyvinylidene chloride affixed to the first surface of the slide by a layer of double-sided adhesive, wherein the adhesive layer is deposited on the first surface of the slide and encloses an area thereupon; (d) a first and second port extending through the slide from the first surface to the second surface thereof each having a first opening and a second opening, wherein the first opening of each port is provided within the area on the first surface of the slide bounded by the adhesive and covered by the flexible layer and the second opening of each port is provided on the second surface of the slide, and wherein each port is in the shape of a truncated cone having a small-diameter end and a large diameter end, and wherein the small diameter end is the first opening and the large diameter end is the second opening; (e) a layer of foil tape positioned over the second opening of each port; (f) a layer of a polyethylene glycol positioned between the first surface of the slide and the layer of polyvinylidene chloride; (g) a reflective layer positioned between the array and the first substrate surface; (h) a layer of parylene positioned between the reflective layer and the layer of polyvinylidene chloride; and (i) a resistive heater.