Patent ID: 6271371
Filing Date: 2001-08-07
Classification: C07D,Y02P

Abstract:
A process for the preparation of a compound of formula (2), comprising phenolic oxidation of a compound of formula (1) ##STR3##wherein X.sup.1 and X.sup.2 are independently selected from H or a protecting group for the phenolic function; groups A.sup.1, A.sup.2, B.sup.1, B.sup.2 and Y are selected from the group consisting of (i) wherein each of A.sup.1, A.sup.2, B.sup.1 and B.sup.2 are H and Y is COR.sup.1, wherein R.sup.1 is selected from the group consisting of H, alkyl, aryl, arylalkyl, and alkyloxy; (ii) wherein A.sup.1 and A.sup.2 are H, B.sup.1 and B.sup.2 are, together, O, and Y is H or Me; and (iii) wherein A.sup.1 and A.sup.2 are, together, O, B.sup.1 and B.sup.2 are H, and Y is H or Me; Z is a blocking group; and R is selected from the group consisting of H, alkyl, aryl, and arylalkyl, and wherein the process is carried out in a two phase liquid system comprising an aqueous base and an organic solvent having a dielectric constant below 4.8, as measured at 20.degree. C., wherein said solvent is toluene.