Patent ID: 8916168
Filing Date: 2014-12-23
Classification: A61K,A61P,Y02A

Abstract:
1. A vaccine composition comprising a fusion polypeptide and an immunostimulant, wherein the fusion polypeptide comprises a first polypeptide and a second polypeptide, wherein the second polypeptide is heterologous fusion partner as to the first polypeptide, wherein the first polypeptide comprises a recombinant Leishmania sterol 24-c-methyltransferase (SMT) polypeptide comprising an amino acid sequence of SEQ ID NO:1, or a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:1, and the immunostimulant comprises a synthetic CpG unmethylated dinucleotide (CpG-containing oligonucleotide), a synthetic lipid A, monophosphoryl lipid (MPL) adjuvant, 3-de-O-acylated monophosphoryl lipid A (3D-MPL) adjuvant, an aminoalkyl glucosaminide 4-phosphates (AGP), a synthetic Toll-like receptor agonist or a combination thereof and the fusion polypeptide and the immunostimulant are present in amounts effective to induce an immune response.