Patent ID: 6646003
Filing Date: 2003-11-11
Classification: A61K,A61P,Y10S

Abstract:
A method of treating an ophthalmic inflammatory or angiogenesis-related disorder of the posterior segment of the eye in a patient suffering from or predisposed to such a disorder which comprises topically administering to the eye of the patient a therapeutically effective amount of a compound having the formula (I) or (II): whereinR1&boxH;H, C1-6(un)branched alkyl, (un)substituted (substitution as defined by Z below), â€”(CH2)nâ€”Xâ€”(CH2)nâ€²A; R2&boxH;H, C1-3 alkyl, OR3; R3&boxH;H, C1-3 alkyl; R4&boxH;H, Meâ€”, MeOâ€”, MeSâ€”; R5&boxH;H, Meâ€”; X=nothing (carbonâ€”carbon bond), O, C&boxH;O, OC(&boxH;O), C(&boxH;O)O, C(&boxH;O)NR3, NR3C(&boxH;O), S(O)n2, CHOR3, NR3; X2, X2â€² independently=H, F; n=2-6; nâ€²=1-6; n2=0-2; A=H, OH, optionally (un)substituted aryl (substitution as defined by Z below), (un)substituted heterocycle (substitution as defined by Z below); and Z&boxH;H, Cl, F, Br, I, OR3, CN, OH, CF3, R4, NO2.