Patent ID: 6552183
Filing Date: 2003-04-22
Classification: A61P,C07H

Abstract:
A compound having a structure according to Formula III: wherein:X is independently O, S, CH2 and NR, where R is COCH3; Râ€² and Râ€³ are independently selected from the group consisting of H, CN, C(&boxH;O)NH2, NH2, C(&boxH;S)NH2, C(&boxH;NH)NH2.HCl, C(&boxH;NOH)NH2, C(&boxH;NH)OMe, a halogen, lower alkyl and a lower alkyl aryl; R1 and R4 are independently selected from the group consisting of H, CN, N3, CH2OH, lower alkyl and a lower alkyl amino; and R2, R3, R5, R6, R7 and R8 are independently selected from the group consisting of H, OH, CN, N3, a halogen, CH2OH, NH2, OCH3, NHCH3, ONHCH3, SCH3, SPh, alkenyl, lower alkyl, and a lower alkyl amino, with the proviso that when R2&boxH;R3&boxH;H, then each of R7 and R8 is a hydrogen or taken together are a &pgr;-bond; and where in compounds of Formula III, Râ€² is carboxamide or CN and Râ€³ is hydrogen or a halogen; R1&boxH;R4&boxH;R5&boxH;R7&boxH;R8 H and R2&boxH;R3&boxH;OH, and X is oxygen.