Patent ID: 6310066
Filing Date: 2001-10-30
Classification: C07D

Abstract:
A compound according to the formula: ##STR8##whereinR.sub.1 and R.sub.2 are each independently selected from H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR.sub.5, nitro, amino, CF.sub.3 and when R.sub.1 and R.sub.2 are taken together, form a fused ring at the 2,3- or 3,4- positions providing a fused phenyl group or a benzodioxane group, or a 4- or 7-substituted indole group, or a 5- or 8-substituted quinoline group;the group formed by the fusion of R.sub.1 and R.sub.2 being taken together is further optionally substituted by from 1 to 3 groups selected from H, COOH or the C.sub.1 to C.sub.6 alkyl esters thereof, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, OR.sub.5, --C(O)NR.sub.6 R.sub.7, nitro, amino, or CF.sub.3 ;R.sub.3 represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen;R.sub.4 represents a group selected from hydrogen, 1 to 6 carbon alkyl or R.sub.5 ;R.sub.5 is CH.sub.2 Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, CF.sub.3 ;R.sub.6 and R.sub.7 are independently selected from H or C.sub.1 to C.sub.6 alkyl;X is N;A is selected from a group represented by N, CH and CH.sub.2 ; andB is selected from a group represented by .dbd.O, H and H.sub.2 ; such that the moiety in formula (1) represented by the formula: ##STR9##with the proviso that when R.sub.1 and R.sub.2 taken together with the ring to which they are attached form a 4- or 7-substituted indole group, then B is .dbd.O;or a pharmaceutically acceptable salt thereof.