Patent ID: 7795012
Filing Date: 2010-09-14
Classification: C12M

Abstract:
1. A device for carrying out of investigations on living cells, cell cultures and for detection of metabolic activity of the cells, which are located in a liquid medium, the device comprises at least one receptacle for liquid medium along with the cell culture, and wherein one or more measuring apparatuses and/or sensors for measurement of the cell culture are provided and wherein a movable separating element is provided, which confiningly borders a reaction space, the separating element ( 7 , 7 a ) is placed in a measurement position, closely above a cell culture on a bottom of the receptacle to separate a reaction space ( 8 , 8 a ) from a reservoir space wherein a volume of the reservoir space is an order of magnitude greater than a volume of the reaction space ( 8 , 8 a ), and the separating element ( 7 , 7 a ) is movable through one of an essentially vertical up and down motion, from a bottom proximal location, which covers the cell culture and serves as the measurement position, and a bottom distal position, in at least which position, the reservoir ( 14 , 14 a ) is in fluid communication with the reaction space ( 8 , 8 a ), or a forward and back, lateral motion between the measurement position and a position in which the reaction space ( 8 , 8 a ) is in fluid communication with the reservoir ( 14 , 14 a ), the one or more measuring apparatuses and/or sensors comprises at least one sensor that is placed on, or in, the bottom of the receptacle ( the bottom of the receptacle is formed by at least one part of at least one wafer upon which the at least one sensor ( an open top container, is provided as a receptacle (