Patent ID: 6680339
Filing Date: 2004-01-20
Classification: A61K,C07C

Abstract:
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: wherein:R1=CO2R, CONR4R5, CH2OR6, or CH2NR7R8; where R=H or cationic salt moiety, or CO2R=ophthalmically acceptable ester moiety; R4, R5=same or different=H or alkyl; R6=H, acyl, or alkyl; R7, R8=same or different=H, acyl, or alkyl; with the proviso that if one of R7, R8=acyl, then the other=H or alkyl; n=0 or 2; - - - =a single bond between carbons 5 and 6, a cis double bond between carbons 4 and 5, and a single or trans double bond between carbons 13 and 14; R2, R3=same or different=H, alkyl, or acyl; D, D1=different=H and fluorine; X=(CH2)q or (CH2)qO; where q=1-6; and Y=a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; or X-Y=(CH2)pY1; where p=0-6; and wherein:W=CH2, O, S(O)m, NR9, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)m, CH&boxH;N, or CH2NR9; where m=0-2, and R9=H, alkyl, or acyl; Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and - - -=single or double bond.