Patent ID: 6783761
Filing Date: 2004-08-31
Classification: A61K,A61P,C07K,Y02A

Abstract:
A synthetic immunogen for inducing specific antibodies against GnRH comprising:(i) a promiscuous helper T-lymphocyte epitope selected from the group consisting of SEQ ID NO: 8 of measles virus protein F (MVP-F), SEQ ID NO: 2, SEQ ID NO: 4 of tetanus toxoid (TT), and SEQ ID NO: 3 of malaria circumsporozoitc protein (M-CSP), fused through (ii) a spacer peptide selected from the group consisting of Gly-Pro-Ser-Leu (SEQ ID NO: 5), Ser-Ser-Gly-Pro-Ser-Leu (SEQ ID NO: 6), and Ser-Ser-Gly-Pro-Ser-Leu-Lys-Leu (SEQ ID NO: 7) to (iii) a GnRH immunonmimic peptide comprising either the amino acid sequence of SEQ ID NO: 1, or amino acids 2-10 of SEQ ID NO: 1.