Patent ID: 9044494
Filing Date: 2015-06-02
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method of upregulating a function of and/or the expression of a Fibroblast growth factor 21 (FGF21) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specifically hybridizable to a natural antisense polynucleotide of the FGF21 gene and has at least 80% sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 consecutive nucleotides within nucleotides 1 to 4246 of SEQ ID NO: 2; thereby upregulating a function of and/or the expression of the Fibroblast growth factor 21 (FGF21) polynucleotide in patient cells or tissues in vivo or in vitro.