Patent ID: 6420604
Filing Date: 2002-07-16
Classification: A61K,A61Q,C07C,C07H

Abstract:
A process for the preparation of an N-acylated amino alcohol comprising the N-acylation of an amino alcohol or a salt thereof with an organic acid of formula Râ€”COOH,wherein R is hydrogen; an optionally unsaturated, optionally substituted, optionally one or more heteroatoms containing straight chain or branched alkyl group having up to 55 carbon atoms; an optionally unsaturated, optionally substituted, optionally one or more heteroatoms containing C5-8 cycloalkyl group; an optionally substituted aryl or heteroaryl group; or an optionally substituted benzyl group, the organic acid being in the form of an acid halogenide, wherein the coupling (N-acylation) occurs in an organic solvent in the additional presence of water.