Patent ID: 7321055
Filing Date: 2008-01-22
Classification: C07C

Abstract:
1. A method of producing an optically active diphenylalanine compound represented by formula (3): wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a nitro group, a hydroxyl group, or a protected hydroxyl group, each n is independently an integer of 1 to 5, P 1 is an amino-protecting group, * indicates an asymmetric carbon atom, and the configuration of each asymmetric carbon atom is S or R, which method comprises: (i) reacting a diphenylalanine compound represented by formula (1): wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a nitro group, a hydroxyl group, or a protected hydroxyl group, each n is independently an integer of 1 to 5, and P 1 is an amino-protecting group, with an optically active amine compound represented by formula (2): wherein R 3 is a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a hydroxyl group, a protected hydroxyl group, a cyano group, a nitro group, or an acyl group, or two adjacent R 3 are optionally condensed to form a benzene ring, n is an integer of 1-5, * indicates an asymmetric carbon atom, and the configuration of each asymmetric carbon atom is S or R; and (ii) separating the resulting diastereomeric salt.