Patent ID: 6303638
Filing Date: 2001-10-16
Classification: C07D

Abstract:
A compound having the structural formula (I) ##STR35##wherein:R has the structure ##STR36##R.sup.1 is halo or C.sub.1 -C.sub.8 alkyl;R.sup.2 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, C.sub.1 -C.sub.8 alkoxy, cyano, halo and nitro;R.sup.3 is hydrogen or C.sub.1 -C.sub.8 alkyl;X is selected from the group consisting of --CHR.sup.7.dbd.CHR.sup.8 --, --CR.sup.7 R.sup.8 --CR.sup.9 R.sup.10 --(CR.sup.11 R.sup.12).sub.P --(CR.sup.13 R.sup.14).sub.q --, --CR.sup.7 R.sup.8 --NH--CR.sup.9 R.sup.10 --, --CR.sup.7 R.sup.8 --N(CH.sub.3)--CR.sup.9 R.sup.10 --, --CR.sup.7 R.sup.8 --O--CR.sup.9 R.sup.10 -- and --CR.sup.7 R.sup.8 --S--CR.sup.9 R.sup.10 -- wherein R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 are independently hydrogen or C.sub.1 -C.sub.8 alkyl and p and q are independently zero or 1;Y is selected from the group consisting of CR.sup.15 R.sup.16, NR.sup.17, O and S, wherein R.sup.15 and R.sup.16 are independently hydrogen or C.sub.1 -C.sub.8 alkyl, and R.sup.17 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl or C.sub.2 -C.sub.8 alkynyl;Z is selected from the group consisting of NH, O and S; andn is 1, 2 or 3,and pharmaceutically acceptable salts thereof,with the proviso that when Z is NH and X is --CH.sub.2 --CH.sub.2 --, then Y is other than NH.