Patent ID: 6596724
Filing Date: 2003-07-22
Classification: C07D

Abstract:
A compound of Formula (I) or its pharmaceutically acceptable acid addition salts or hydrates thereof wherein B is â€ƒwith X being O, S or â€ƒand X1 is O or S; R1 and R4 are independently selected from the group consisting of CO2R6, â€ƒcyano, and â€ƒR2 and R3 are independently selected from the group consisting of hydrogen, cyano and lower alkyl; R5 is selected from either hydrogen or halogen; R6 is lower alkyl; n is an integer selected from 1 to 5; â€ƒin which R7 and R8 are independently selected from the group consisting of lower alkyl and hydroxy-lower-alkyl; R9 is selected from the group consisting of hydrogen, lower alkyl, â€”CO2R6, â€”(CH2)mR10, hydroxy, cyano, and â€”(CH2)mNR11R12, wherein m is zero or an integer from 1 to 3; R10 is C3-7 cycloalkyl, naphthyl, or â€ƒwith R13 selected from the group consisting of lower alkyl, lower alkenyl, C3-7 cycloalkyl, lower alkoxy, hydrogen, halogen, hydroxy, dialkylamino, phenoxy, amino, â€”NHCOR6, â€”CO2R6, NO2, trifluoromethyl, and phenyl, and R11 and R12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, phenyl, alkylamino, heterocyclic alkyl, methoxy, cyano, hydroxy-lower alkyl, naphthyl, furfuryl, tetrahydrofurfuryl, thienyl, azetidinyl, â€”CO2R6, â€”CH2CONH2, and â€”O2CNH2 and where â€”NR11R12 is a heterocyclic amine or imine.