Patent ID: 7989589
Filing Date: 2011-08-02
Classification: A61K,A61P,C07K

Abstract:
1. A compound that inhibits complement activation, which comprises a peptide having a sequence: wherein: Xaa1 is Ile, Val, Leu, Ac-Ile, Ac-Val, Ac-Leu or a dipeptide comprising Gly-Ile; Xaa2 is Trp or a peptidic or non-peptidic analog of Trp; Xaa3 is His, Ala, Phe or Trp; Xaa4 is L-Thr, D-Thr, Ile, Val, Gly, or a tripeptide comprising Thr-Ala-Asn, wherein a carboxy terminal —OH of any of the L-Thr, D-Thr, Ile, Val, Gly or Asn optionally is replaced by —NH the two Cys residues are joined by a disulfide bond.