Patent ID: 6235778
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formula I: ##STR33##or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:R.sup.1 is one of C.sub.3-8 alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, any of which may be optionally substituted;Z is --OSO.sub.2 -- or --SO.sub.2 O--;R.sup.y and R.sup.z are each independently one of hydrogen, alkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or carboxy;R.sup.2, R.sup.3 and R.sup.4 are each independently one of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamido, --CO.sub.2 R.sup.x, --CH.sub.2 OR.sup.x or --OR.sup.x, or when present on adjacent carbon atoms, R.sup.2 and R.sup.3 may also be taken together to form one of --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.q --, where q is from 2 to 6, and R.sup.4 is defined as above;R.sup.x, in each instance, is independently one of hydrogen, alkyl or cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations;Y is one of --O--, --NR.sup.10 --, --S--, --CHR.sup.10 -- or a covalent bond;X is oxygen or NR.sup.9 ;R.sup.9 is one of hydrogen, alkyl, cycloalkyl or aryl, wherein said alkyl, cycloalkyl or aryl can be optionally substituted with amino, monoalkylamino, dialkylamino, alkoxy, hydroxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, aryl, acylamino, cyano or trifluoromethyl;R.sup.6 is one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C.sub.2-10)alkyl, dialkylamino(C.sub.2-10)alkyl or carboxyalkyl; or R.sup.6 and R.sup.12 are taken together to form --(CH.sub.2).sub.w --, where w is 1-5;R.sup.7 is one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, hydroxy, alkoxy, aralkoxy, aryloxy, or mono- or di-alkylamino, provided that n is other than zero when R.sup.7 is hydroxy, alkoxy, aralkoxy, aryloxy, or mono- or di-alkylamino; R.sup.8, R.sup.11 and R.sup.12 are each independently one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or carboxyalkyl; or R.sup.7 and R.sup.8 are taken together to form --(CH.sub.2).sub.y --, where y is zero (a bond), 1 or 2, while R.sup.11 and R.sup.12 are defined as above; or R.sup.7 and R.sup.12 are taken together to form --(CH.sub.2).sub.q --, where q is zero (a bond), or 1 to 8, while R.sup.8 and R.sup.11 are defined as above; or R.sup.8 and R.sup.11 are taken together to form --(CH.sub.2).sub.r --, where r is 2-8, while R.sup.7 and R.sup.12 are defined as above;R.sup.10, in each instance, is independently one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C.sub.2-10)alkyl, dialkylamino(C.sub.2-10)alkyl or carboxyalkyl;R.sup.a, R.sup.b and R.sup.c are independently hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano or --CO.sub.2 R.sup.w ;R.sup.w is alkyl, cycloalkyl, phenyl, benzyl, ##STR34##where R.sup.d and R.sup.e are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.f is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.g is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, and R.sup.h is aralkyl or C.sub.1-6 alkyl;n is from zero to 8; and m is from zero to 4.