Patent ID: 6140332
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A 7H-pyrrolo[2,3-d]pyrimidine derivative of formula I ##STR23## wherein q is 0 or 1,n is from 1 to 3 when q is 0, or n is from 0 to 3 when q is 1,R is halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, cyano, amino, lower alkanoylamino, lower alkylamino, N,N-di-lower alkylamino or trifluoromethyl, it being possible when several radicals R are present in the molecule for those radicals to be identical or different,a) R.sub.1 and R.sub.2 are each independently of the other.alpha.) phenyl substituted by carbamoylmethoxy, carboxy-methoxy, benzyloxycarbonylmethoxy, lower alkoxycarbonyl-methoxy, phenyl, amino, lower alkanoylamino, lower alkylamino, N,N-di-lower alkylamino, hydroxy, lower alkanoyloxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, cyano or by nitro;.beta.) hydrogen, with the proviso that R.sub.1 and R.sub.2 are not hydrogen simultaneously;.gamma.) unsubstituted or halo- or lower alkyl-substituted pyridyl;.delta.) N-benzyl-pyridinium-2-yl; naphthyl; cyano; carboxy; lower alkoxycarbonyl; carbamoyl; N-lower alkyl-carbamoyl; N,N-di-lower alkyl-carbamoyl; N-benzylcarbamoyl; formyl; lower alkanoyl; lower alkenyl; lower alkenyloxy; or.epsilon.) lower alkyl substituted by.epsilon..alpha.) halogen, amino, lower alkylamino, piperazino, di-lower alkylamino,.epsilon..beta.) phenylamino that is unsubstituted or substituted in the phenyl moiety by halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, cyano, amino, lower alkanoylamino, lower alkylamino, N,N-di-lower alkylamino or by tyrifluoromethyl,.epsilon..gamma.) hydroxy, lower alkoxy, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, mercapto or.epsilon..delta.) a radical of the formula R.sub.3 --S(O).sub.m -- wherein R.sub.3 is lower alkyl and m is 0, 1 or 2, orb) when q is 0, one of the radicals R.sub.1 and R.sub.2 is unsubstituted lower alkyl or unsubstituted phenyl and the other of the radicals R.sub.1 and R.sub.2 has one of the meanings given above in paragraph a) with the exception of hydrogen, orc) when q is 1, R.sub.1 and R.sub.2 are each independently of the other unsubstituted lower alkyl with the exception of methyl or unsubstituted phenyl or have one of the meanings given above in paragraph a), andR.sub.6 is hydrogen, lower alkyl, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl or N,N-di-lower alkyl-carbamoyl,or a salt thereof,with the exception of the compound of formula I wherein n is 0, q is 1, R.sub.1 and R.sub.6 are each hydrogen and R.sub.2 is methyl, the compound of formula I wherein n is 2, q is 1, R.sub.1 and R.sub.6 are each hydrogen, R.sub.2 is methyl and R is 3,4-methoxy and the compounds of formula I wherein n is 1, q is 0, R.sub.1 is 3-pyridyl, 4-cyanophenyl or 4-hydroxyphenyl, R.sub.2 is hydrogen and R is fluoro.