Patent ID: 8669350
Filing Date: 2014-03-11
Classification: A61K,A61P,C07K

Abstract:
1. A fusion protein comprising three or six monomer polypeptides, wherein each monomer polypeptide independently comprises: (a) a single domain antibody, or an extracellular domain of a TNF receptor in a TNF receptor family, (b) a collagen-like domain comprising at least 8 G-P-X1 blocks, a trimerizing motif, and wherein X1 is P or O, (c) optionally, a hinge region of IgG or a glycine linker, and (d) an Fc domain comprising the CH2 and CH3 regions of human IgG wherein the trimerizing motif comprises SEQ ID NO: 34, or a variation thereof which comprises one or more of the following structures: SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, and SEQ ID NO: 45.