Patent ID: 9132163
Filing Date: 2015-09-15
Classification: A61K,B01D,C07K

Abstract:
1. A method for producing a pharmaceutically acceptable Micafungin salt comprising the steps of: a) applying a Micafungin starting material to a hydrophobic adsorbent resin support, wherein the Micafungin starting material comprises a Micafungin salt and the Micafungin is adsorbed to the hydrophobic adsorbent resin support; b) exposing the adsorbed Micafungin to an aqueous solution of a dissolved pharmaceutically acceptable salt to produce a pharmaceutically acceptable salt of Micafungin; c) washing the adsorbed Micafungin with a washing solution; and d) eluting the pharmaceutically acceptable salt of Micafungin with an elution solution comprising a water miscible organic solvent; provided that at least one of i) the Micafungin starting material in step a) or ii) the aqueous solution of the dissolved pharmaceutically acceptable salt in step b) comprises a water miscible organic solvent, wherein the Micafungin salt and the pharmaceutically acceptable salt of Micafungin are different.