Patent ID: 6462182
Filing Date: 2002-10-08
Classification: C07H

Abstract:
A glycosylated analog of fusidic acid synthesized by a method comprising the steps:a) providing in any order: i) an unmodified fusidic acid, wherein said fusidic acid has an acetate group at the C-16 position, ii) a derivatizing reagent selected from the group consisting of carbohydrate glycals and activated carbohydrate glycals, wherein said carbohydrate glycals and said activated carbohydrate glycals are olefins, and iii) a catalyst; b) reacting said hydroxylated fusidic acid, said derivatizing reagent, and said catalyst under conditions such that a glycosylated analog of fusidic acid is produced; and c) Hydrolyzing said glycosylated analog of fusidic acid under conditions such that said acetate group at said C-16 position is not hydrolyzed.