Patent ID: 6956047
Filing Date: 2005-10-18
Classification: A61K

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein A is —CR B is —NR Z is NH, O, S, —N (C R or when R R 1 and R 2 of B may form a saturated 5- to 8-membered ring which may optionally contain one or two double bonds and in which one or two of the ring carbons may optionally be replaced by an oxygen, S(O) m , nitrogen or NR 12 ; and which carbocyclic ring can optionally be substituted with from 1 to 3 substituents selected from the group consisting of hydroxy, C 1 -C 4 alkyl, fluoro, chloro, bromo, iodo, CF 3 , —O—(C 1 -C 4 alkyl), —O—CO—(C 1 -C 4 alkyl), —O—CO—NH(C 1 -C 4 alkyl), —O—CO—N(C 1 -C 4 alkyl)(C 1 -C 2 alkyl), —NH(C 1 -C 4 alkyl), —N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), —S(C 1 -C 4 alkyl), —N(C 1 -C 4 alkyl)CO(C 1 -C 4 alkyl), —NHCO(C 1 -C 4 alkyl), —COO(C 1 -C 4 alkyl), —CONH(C 1 -C 4 alkyl), —CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), CN, NO 2 , —OSO 2 (C 1 -C 4 alkyl), —SO(C 1 -C 4 alkyl), and —SO(C 1 -C 4 alkyl), wherein one of said one to three substituents can further be selected from phenyl; R R R R R R R R R R wherein each m is independently zero, one, or two, with the proviso that heterocyclohydrocarbylene groups of the compound of formula I, do not comprise any —S—S—, —S—O—, —N—S—, or —O—O—bonds, and do not comprise more than two oxygen or S(O)