Patent ID: 6803365
Filing Date: 2004-10-12
Classification: A61P,C07D

Abstract:
An imidazo[1,3,5]triazinone of formula (I) in whichR1 represents straight-chain or branched alkyl having up to 4 carbon atoms, R2 represents straight-chain or branched alkyl having up to 4 carbon atoms or represents (C3-C8)-cycloalkyl, R3 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms, R4 and R5 are identical or different and represent hydrogen, (C1-C6)-alkoxy or hydroxyl or represent (C1-C8)-alkyl which is optionally substituted, up to 3 times, identically or differently, by hydroxyl or (C1-C6)-alkoxy or by radicals of the formulae â€ƒin which R6 and R7 are identical or different and denote hydrogen or (C1-C6)-alkyl, and/or, for its part, (C1-C8)-alkyl is optionally substituted by phenyl or phenoxy which, for their part, are optionally substituted, once to three times, identically or differently, by halogen, hydroxyl, (C1-C6)-alkoxy or (C1-C6)-alkyl or by a radical of the formula â€”SO2NR8R9, in which R8 and R9 are identical or different and denote hydrogen or (C1-C6)-alkyl, or R4 represents hydrogen or methyl, and R5 represents radicals of the formulae â€ƒor represents phenyl which is optionally substituted, up to 3 times, identically or differently, by halogen, acetyl or (C1-C6)-alkoxy or by radicals of the formulae â€ƒâ€”NR10R11 or â€”CH2â€”P(O)(OR12)(OR13) â€ƒin which R10 and R11 are identical or different and denote hydrogen or (C1-C4)-alkyl, R12 and R13 are identical or different and denote hydrogen or (C1-C6)-alkyl, or R4 and R5, together with the nitrogen atom to which they are bonded, form radicals of the formulae â€ƒin which R14 and R15 are identical or different and denote hydroxyl, hydrogen or (C1-C4)-alkyl which is optionally substituted by hydroxyl, or R14 denotes hydrogen, and R15 denotes a radical of the formula â€ƒor R14 and R15 together form a radical of the formula &boxH;Nâ€”Oâ€”CH3, R16 denotes hydrogen or (C1-C6)-alkyl which is optionally substituted by hydroxyl, or a 5- to 6-membered, aromatic heterocycle having up to 3 heteroatoms from the series S, N and/or O, or the salts, N-oxides and isomeric forms thereof.