Patent ID: 6506778
Filing Date: 2003-01-14
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of the formula (I) whereinA is phenyl, or naphthyl, wherein the phenyl or naphthyl radical is optionally substituted up to three times by one or more of the following radicals: F, Cl, Br, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, Oâ€”(C1-C6)-alkenyl, Oâ€”(C1-C6)-alkynyl, Sâ€”(C1-C6)-alkyl, Sâ€”(C1-C6)-alkenyl, Sâ€”(C1-C6)-alkynyl, SOâ€”(C1-C6)-alkyl, SO2â€”(C1-C6)-alkyl, SO2â€”NH2, (C1-C6)-alkyl, (C1-C6)-alkenyl, (C1-C6)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkylene, (C1-C6)-alkylene-COOH, (C0-C6)-alkylene-COO(C1-C7)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON[(C1-C6)-alkyl]2, CONH(C3-C6)-cycloalkyl, (C0-C6)-alkylene-NH2, (C0-C6)-alkylene-NH(C2-C6)-alkyl, (C0-C6)-alkylene-N[(C1-C6)-alkyl]2, NHâ€”COâ€”(C1-C6)-Alkyl, NHâ€”CO-phenyl, or NHâ€”SO2-phenyl, wherein the phenyl ring in NHâ€”CO-phenyl, or NHâ€”SO2-phenyl is optionally substituted up to twice by one or two of the following radicals: F, Cl, CN, OH, (C1-C6)-alkyl, Oâ€”(C1-C6)-alkyl, CF3, OCF3, COOH, COO(C1-C6)-alkyl, or CONH2; R1, R2 are, independently of one another: H, (C1-C6)-alkyl, Oâ€”(C1-C6)-alkyl, COâ€”(C1-C6)-alkyl, COOâ€”(C1-C6)-alkyl, (C1-C6)-alkylene-COOH, or (C1-C6)-alkylene-COOâ€”(C1-C6)-alkyl; R3, R4, R5, R6 are, independently of one another: H, F, Cl, Br, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, Oâ€”(C1-C6)-alkenyl, Oâ€”(C1-C6)-alkynyl, Sâ€”(C1-C6)-alkyl, Sâ€”(C1-C6)-alkenyl, Sâ€”(C1-C6)-alkynyl, SOâ€”(C1-C6)-alkyl, SO2â€”(C1-C6)-alkyl, SO2â€”NH2, (C1-C6)-alkyl, (C1-C6)-alkenyl, (C1-C6)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkylene, COOH, COO(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON[(C1-C6)-alkyl]2, CONH(C3-C7)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N[(C1-C6)-alkyl]2, NHâ€”COâ€”(C1-C6)-alkyl, NHâ€”CO-phenyl, or NHâ€”SO2-phenyl, wherein the phenyl ring in NHâ€”CO-phenyl, or NHâ€”SO2-phenyl is optionally substituted up to twice by one or two of the following radicals: F, Cl, CN, OH, (C1-C6)-Alkyl, Oâ€”(C1-C6)-alkyl, CF3, OCF3, COOH, COO(C1-C6)-alkyl, or CONH2; X is O or S; R7 is (C1-C10)-alkylene-COOH, (C6-C10)-alkylene-COOâ€”(C1-C6)-alkyl, (C1-C10)-alkylene-CONH2, (C1-C10)-alkylene-CONHâ€”(C1-C6)-alkyl, (C1-C10)-alkylene-CONâ€”[(C1-C6)-alkyl]2, (C1-C10)-alkylene-NH2, (C4-C10)-alkylene-NHâ€”(C1-C6)-alkyl, (C1-C10)-alkylene-N[(C1-C6)-alkyl]2, or (C1-C10)-alkylene-B; â€ƒwherein B is (C3-C7)-cycloalkyl, phenyl, pyrrolyl, imidazolyl, thiazolyl, azetidinyl, thienyl, piperidinyl, pyrrolidinyl, morpholinyl, pyridyl-methyl, or furyl, wherein cycloalkyl, phenyl, pyrrolyl, imidazolyl, thiazolyl, azetidinyl, thienylmethyl, piperidinyl, pyrrolidinyl, morpholinyl, pyridyl or furyl may in each case be optionally substituted up to twice by one or two of the following radicals: Cl, F, CN, CF3, OCF3, COOH, COOâ€”(C1-C6)-alkyl, CONH2, CONHâ€”(C1-C6)-alkyl, CONâ€”[(C1-C6)-alkyl]2, (C1-C6)-alkyl, OH, or Oâ€”(C1-C6)-alkyl; or a physiologically tolerated salt thereof,except the compounds of the formula except compounds of the formula (I) in which the radicals are, at the same time:Aphenyl;XO;R1H;R7-(C1-C4)-alkyl-B;B(C3-C7)-cycloalkyl, or heteroaryl; andwherein, in the compounds of the formula (I) when X=O; R1-R2=H; and one of R3-R6 is Cl and the others are hydrogen, the (C1-C10)-alkylene-COOH group in R7 is instead a (C2-C10)-alkylene-COOH group.