Patent ID: 8426617
Filing Date: 2013-04-23
Classification: C07B,C07C,C07D

Abstract:
1. Process for the manufacture of a compound of the formula I wherein the position labelled with the asterisk is an asymmetry center and R with R comprising the step of hydrogenating a compound of the formula II wherein at least one carbon-carbon double bond is present, and wherein the dotted lines represent the possible positions of such (facultative) carbon-carbon double bonds; and R in the presence of a chiral iridium (Ir) complex as the catalyst selected from the group consisting of Ir complexes of the formula III, IV, V, VI, VII, VIII, IX, X, XI or XV, and their enantioners of formula: wherein R, X the anion Y is a weakly coordinating anion, n is 1 to 2, and “o-Tol” means ortho-tolyl, “Ph” means phenyl, “TBDMS” means tert-butyl-dimethylsilyl, “p-Tol” means para-tolyl, “BAr and the Ir complexes of the formula III to XI and XV, and the corresponding enantiomeric formula whereby the cyclooctadiene ligand is replaced by ethene or norbornadiene.