Patent ID: 8227628
Filing Date: 2012-07-24
Classification: C07D

Abstract:
1. A method of providing optically pure acetonide-protected 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH), comprising: a. protecting the amine group of L-DOPA with a phthaloyl group to yield Phth-DOPA-OH, the Phth-DOPA-OH comprising a carboxyl group; b. protecting the carboxyl group of Phth-DOPA-OH with a methyl ester to yield Phth-DOPA-OMe; c. converting Phth-DOPA-OMe via acetonide cyclization to yield Phth-DOPA(acetonide)-OMe; and d. deprotecting Phth-DOPA(acetonide)-OMe to yield optically pure H-DOPA(acetonide)-OH.