Patent ID: 9145564
Filing Date: 2015-09-29
Classification: A61K,A61P,C12N

Abstract:
1. A recombinant Sendai virus genome, comprising: a mutated L gene which encodes a mutated L protein of a persistently non-infective Sendai virus, in which mutated L protein an amino acid residue at position-1088 is serine, an amino acid residue at position-1169 is threonine, an amino acid residue at position-1207 is cysteine, an amino acid residue at position-1618 is valine, and an amino acid residue at position-1664 is isoleucine; an NP gene of the persistently non-infective Sendai virus; a P gene of the persistently non-infective Sendai virus; and the recombinant Sendai virus genome lacking (A) an HN gene and (B) at least one of an M gene and an F gene, wherein a transcription termination sequence is added to the 3′ terminus of a leader RNA sequence of a Sendai virus.