Patent ID: 8980248
Filing Date: 2015-03-17
Classification: A61K,A61L

Abstract:
1. An injectable cell delivery composition comprising as a cell delivery vehicle a polymer composition comprising: i) at least one thermal gelling polymer; ii) at least one anionic gelling polymer; and iii) a water-based carrier, wherein the polymer composition is injectable due to its shear thinning properties, the viscosity and network density of said polymer composition being effective to promote cell survival in vivo and in vitro and to maintain a distribution of cells after injection; and at least one cell type for delivery selected from the group consisting of mammalian cells, stem cells, precursor and progenitor cell populations isolated from the adult neural subventricular zone, hippocampal subgranular zone, spinal cord, skin-derived precursors or adult retinal ciliary epithelium and their undifferentiated and differentiated progeny; embryonic stem cells and their undifferentiated and differentiated progeny; epiblast stem cells and their undifferentiated and differentiated progeny; primitive and definitive neural stem cells and their undifferentiated and differentiated progeny; induced pluripotent stem cells and their undifferentiated and differentiated progeny; mesenchymal stem cells and their undifferentiated and differentiated progeny; bone-marrow derived stem cells and their undifferentiated and differentiated progeny; hematopoietic stem cells and their undifferentiated and differentiated progeny; umbilical cord derived stem/progenitor cells and their undifferentiated and differentiated progeny; neural precursor cells of the forebrain, midbrain, hindbrain, spinal cord, neural crest, and retinal precursors isolated from developing tissue and their undifferentiated and differentiated progeny; and at least one factor capable of stimulating endogenous stem cells when present.