Patent ID: 8999380
Filing Date: 2015-04-07
Classification: A61K,A61P,C07H,C07K,C12N,C12P,C12Y,Y02A

Abstract:
1. An isolated polynucleotide comprising; (a) a first region of linked nucleosides, said first region encoding a polypeptide of interest, said polypeptide of interest is SEQ ID NO: 1089; (b) a first flanking region located at the 5′ terminus of said first region comprising at least one 5′ terminal cap; (c) a second flanking region located at the 3′ terminus of said first region comprising a 3′ tailing sequence of linked nucleosides; and wherein at least one of said linked nucleosides of (a) comprises at least one modification as compared to the chemical structure of an A, G, U or C ribonucleoside.