Patent ID: 6710179
Filing Date: 2004-03-23
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I) whereinm is 0 or 1; n is 1 or 2; R1 is selected from hydrogen; a branched or straight C1-C6 alkyl; C3-C8 cycloalkyl; C4-C8(alkyl-cycloalkyl) wherein alkyl is C1-C2 alkyl and cycloalkyl is C3-C6 cycloalkyl; benzyl; where G is a hydroaromatic or a heteroaromatic group having 5 or 6 atoms, and where the heteroatoms are selected from O, S and N; and and wherein n=0 or 1; C6-C10 aryl; or heteroaryl having from 5 to 10 atoms selected from any of C, S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, (CH2)pCF3, halogen, CONR5R4, COOR5, COR5, (CH2)pNR5R4, (CH2)pCH3(CH2)pSOR5R4, (CH2)pSO2R5, and (CH2)pSO2NR5, wherein R4 and R5 are each independently as defined below and p is 0, 1 or 2; (C1-C2 alkyl)-(C6-C10 aryl); or (C1-C2 alkyl)heteroaryl, the heteroaryl moieties having from 5 to 10 atoms selected from any of C, S, N and O and where the aryl or heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, CONR5R4, COOR5, COR5, (CH2)qNR5R4, (CH2)qCH3(CH2)qSOR5R4, (CH2)qSO2R5, (CH2)qSO2NR5, and (CH2)qOR4, wherein R4 and R5 are each independently as defined below and q is 0, 1 or 2; A is wherein R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are each independently as defined below and wherein the phenyl ring of each A substituent may be optionally end independently substituted by 1 or 2 substituents Z1 and Z2 which are each and independently selected from hydrogen, CH3, (CH2)rCF3, halogen, CONR2R3, CO2R2, COR2, (CH2)rNR2R3, (CH2)rCH3(CH2)rSOR2, (CH2)rSO2R2 and (CH2)rSO2NR2R3 wherein R2 and R3 are each indpendently as defined below and wherein r is 0, 1 or 2; X is O, S or NR19 where R19 is as defined below; B is a substituted or unsubstituted aromatic, heteroaromatic, hydroaromatic or heterohydroaromatic moiety having from 5 to 10 atoms selected from any of C, S, N an O, optionally and independently substituted by 1 or 2 substituents independently selected from hydrogen, CH3, (CH2)tCF3, halogen, (CH2)tCONR5R4, (CH2)tNR5R4, (CH2)tCOR5, (CH2)tCOOR5, OR5, (CH2)tSOR5, (CH2)tS2R5, and (CH2)tSO2NR5R4, wherein R4 and R5 are each independently as defined below and t is 0, 1, 2 or 3; wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are selected from hydrogen; a branched or straight C1-C6 alkyl; C3-C8 cycloalkyl; C4-C8(alkyl-cycloalkyl) wherein alkyl is C1-C2 alkyl and cycloalkyl is C3-C6 cycloalkyl; benzyl; where G is a hydroaromatic or a heteroaromatic group having 5 or 6 atoms, and where the heteroatoms are selected from O, S and N; and and wherein n=0 or 1; C6-C10 aryl; or heteroaryl having from 5 to 10 atoms selected from any of C, S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, (CH2)pCF3, and halogen and p is 0, 1 or 2; (C1-C2 alkyl)-(C6-C10 aryl); or (C1-C2 alkyl)heteroaryl, the heteroaryl moieties having from 5 to 10 atoms selected from any of C, S, N and O, and where the aryl or heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, and CH3; or the pharmaceutically acceptable salt, isomer, hydrate, isoform or prodrug thereof, and wherein said compound is sufficiently isotopically labeled for diagnostic or imaging purposes.