Patent ID: 6667307
Filing Date: 2003-12-23
Classification: C07C,C07D

Abstract:
Compound represented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein n and t each independently represent 0, 1 or 2;R1 represents hydrogen, alkyl of 1-5 carbon atoms, alkenyl of 2-5 carbon atoms, alkynyl of 2-5 carbon atoms, hydroxyalkyl of 1-3 carbon atoms, alkoxyalkyl of 1-3 alkyl and 1-3 alkoxy carbon atoms, cyanoalkyl of 1-3 alkyl carbon atoms, â€”CH2CONH2, â€”CH2CH2CONH2, â€”CH2S(O)2NH2, â€”CH2SCH3, â€”CH2S(O)CH3 or â€”CH2S(O)2CH3 radicals; R2 represents radicals of alkyl of 1-5 carbon atoms, aralkyl of 1-3 alkyl carbon atoms, alkylthioalkyl of 1-3 alkyl carbon atoms, arylthioalkyl of 1-3 alkyl carbon atoms or cycloalkylalkyl of 1-3 alkyl carbon atoms and 3-6 ring member carbon atoms; R3 represents radicals of alkyl radical of 1-5 carbon atoms, cycloalkyl of 5-8 ring members or cycloalkylmethyl radical of 3-6 ring members; R4 represents benzo fused 5 to 6 ring member heteroaryl or benzo fused 5 to 6 ring member heterocyclo radicals, or a radical of the formula wherein A and B each independently represent O, S, SO or SO2; R6 represents deuterium, alkyl of 1-5 carbon atoms, fluoro or chloro radicals; R7 represents hydrogen, deuterium, methyl, fluoro or chloro radicals; or a radical of the formula wherein Z represents O, S or NH; and R9 represents a radical of formula wherein Y represents O, S or NH; X represents a bond, O or NR21; R20 represents hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 2 to 5 carbon atoms, aralkyl of 1 to 5 alkyl carbon atoms, heteroaralkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, heterocycloalkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, aminoalkyl of 2 to 5 carbon atoms, N-mono-substituted or N,N-disubstituted aminoalkyl of 2 to 5 alkyl carbon atoms wherein said substituents are radicals of alkyl of 1 to 3 carbon atoms, aralkyl of 1 to 3 alkyl carbon atoms radicals, carboxyalkyl of 1 to 5 carbon atoms, alkoxycarbonylalkyl of 1 to 5 alkyl carbon atoms, cyanoalkyl of 1 to 5 carbon atoms or hydroxyalkyl of 2 to 5 carbon atoms; R21 represents hydrogen radical or alkyl radical of 1 to 3 carbon atoms; or the radical of formula â€”NR20R21 represents a 5 to 6 ring member heterocyclo radical; and R22 represents alkyl radical of 1 to 3 carbon atoms or R20R21N-alkyl radical of 1 to 3 alkyl carbon atoms; and R5 represents an alkyl radical of 1-5 carbon atoms, alkenyl radical of 2-5 carbon atoms, alkynyl radical of 2-5 carbon atoms or aryl substituted alkyl radical of 1-5 carbon atoms.