Patent ID: 9161971
Filing Date: 2015-10-20
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method for treating Chronic Lymphocytic Leukemia (CLL) comprising administering to a patient with CLL a single dose comprising a population of about 5×10 9 to about 2×10 10 autologous T cells activated and expanded according to a method comprising, (a) activating a population of T cells in vitro with an agent which stimulates a TCR/CD3 complex-associated signal in the T cells, wherein the agent is attached on a surface; and (b) stimulating a CD28 accessory molecule on the surface of the T cells in vitro with a ligand that binds the CD28 accessory molecule on the surface of the T cells, wherein the ligand is attached on the same surface as the agent; and wherein the activating and stimulating steps thereby induce proliferation of the T cells such that T cell counts are increased in the CLL patient at least one month after administration.