Patent ID: 6214330
Filing Date: 2001-04-10
Classification: A61K,A61P

Abstract:
A compound of the formula: ##STR26##wherein ##STR27##B is H, OH, OSiR.sub.13, a residue of an amine-containing target moiety or a residue of a hydroxyl-containing target moiety;G is ##STR28##or CH.sub.2 ;Y.sub.1 and Y.sub.2 are independently O or S;M is X or Q; whereX is an electron withdrawing group;Q is a moiety containing a free electron pair positioned three to six atoms from C(.dbd.Y.sub.2);R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.13 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.3-12 branched alkyl, C.sub.3-8 cycloalkyl, C.sub.1-6 substituted alkyl, C.sub.3-8 substituted cycloalkyl, aryl, substituted aryl, aralkyl, C.sub.1-6 heteroalkyl, substituted C.sub.1-6 heteroalkyl, C.sub.1-6 alkoxy, phenoxy, C.sub.1-6 heteroalkoxy;R.sub.1 and R.sub.4 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.3-12 branched alkyl, C.sub.3-8 cycloalkyl, C.sub.1-6 substituted alkyl, C.sub.3-8 substituted cycloalkyl, aryl, substituted aryl, aralkyl, C.sub.1-6 heteroalkyl, substituted C.sub.1-6 heteroalkyl, C.sub.1-6 alkoxy, phenoxy, C.sub.1-6 heteroalkoxy, cyano, nitro, carboxyl, acyl, substituted acyl, carboxyalkyl;Ar is a moiety which when included in Formula (I) forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group;(m) is zero or one;(n) is zero or a positive integer;(p) is zero or one;(q) is three or four; andR.sub.11 is a polymer residue.