Patent ID: 6812249
Filing Date: 2004-11-02
Classification: A61K,C07C

Abstract:
A process for the synthesis of 3-hydroxy-3-methylbutyrate or an amino acid salt thereof, in a molar ratio of 0.1:100 to 100:0.1 comprising the steps of:a) reacting an inorganic alkali in water and combining a halogen at a temperature of minus 25 degrees to 50 degrees Celsius to provide an acid solution, b) reacting the product of step a) in an organic alcohol and water solution; decoloring the solution with an inorganic anion; adjusting the water layer to a ph of minus 4 to 7 with an inorganic acid; and extracting the water layer with an organic alcohol to provide a HMB alcohol solution, c) reacting the product of step b) in water and combining an amino acid at 1 to 100 degree Celsius; separating the water layer from the mixture; and removing the water under vacuum for the recovery of the 3-hydroxy-3-methylbutyrate amino acid salt.