Patent ID: 6579452
Filing Date: 2003-06-17
Classification: G01N,H01J,Y10T

Abstract:
A system comprising:a microfabricated device defining a liquid chromatography device comprising an entrance for receiving fluid containing an analyte, the device further defining a monolithic electrospray device having an entrance orifice on an injection side and a nozzle on an ejection surface on an opposite planar side from the injection side, a channel extending continuously through the monolithic device in communication with the entrance orifice and the nozzle, and a region surrounding the nozzle recessed from the ejection surface, the monolithic electrospray device being configured to receive the fluid containing analyte from the liquid chromatography device and to generate an electrospray from the fluid; and a mass spectrometer comprising a sampling orifice, said microfabricated device being positioned to eject the electrospray from the nozzle into the sampling orifice.