Patent ID: 9056318
Filing Date: 2015-06-16
Classification: B01J,B01L,G01N

Abstract:
1. A device for the separation of a component in a liquid sample prior to the detection of an analyte in said liquid sample, said device having a non-porous substrate having a substrate surface and comprising: a sample receiving zone formed in a portion of the substrate; a separator element including a plurality of first projections extending substantially vertical to said substrate surface, said plurality of first projections having a height, diameter, and reciprocal spacing, in which the plurality of first projections, based on at least one of the dimensions or the reciprocal spacing between the first projections, forms a gradient in a direction of flow such that separation of the component occurs, and wherein said separator element is provided adjacent to or in said receiving zone wherein the separator element includes a filtration zone having the plurality of first projections which is arranged as a threshold adjacent to and raised in relation to the sample receiving zone; and a transport or incubation zone connected to said filtration zone thereby forming a lateral flow path on said non-porous substrate extending from the sample receiving zone to the transport or incubation zone, wherein at least part of said flow path outside of the filtration zone has areas of second projections substantially vertical to said substrate surface, said first and second projections each having a height, a diameter and a reciprocal spacing such that lateral capillary flow of said liquid sample in said transport or incubation zone is achieved, said flow path being defined by an open flow path wherein said lateral capillary flow is induced solely due to the height, diameter and reciprocal spacing of said first and said second projections without requiring additional structure to induce or assist said flow.