Patent ID: 9222951
Filing Date: 2015-12-29
Classification: A61B,G01N,G06F

Abstract:
1. A method for operating measuring equipment for detecting at least one analyte in a bodily fluid, the measuring equipment including a continuously monitoring sensor and a reference measurement sensor, the method comprising: implanting the continuously monitoring sensor into the skin of a patient; detecting at least three calibration points, each calibration point comprising (i) a measurement signal obtained from the implanted sensor and corresponding to the concentration of the analyte in the bodily fluid and (ii) a reference value obtained using the reference measurement sensor, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; using the continuously monitoring sensor to perform at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid; and using the one or more sorting algorithms and/or the one or more permutation algorithms during the robust estimation to form a median.