Patent ID: 6232478
Filing Date: 2001-05-15
Classification: C07D

Abstract:
A process of preparing chiral 3,4-epoxybutyric acid of the following formula 1 and the salt thereof, wherein(S)-3-activated hydroxybutyrolactone of the following formula 2 is subjected to a ring-opening reaction in an aqueous solvent, 4-hydroxy-3-activated hydroxybutyric acid of the following formula 3 is prepared therefrom, and4-hydroxy-3-activated hydroxybutyric acid of said formula 3 is subjected to an inversion of the chiral center by epoxydation in the presence of a base in order to prepare 3,4-epoxybutyric acid of the following formula 1 ##STR11##where R is an alkylsulfonyl, arylsulfonyl, acyl group, or phosphoryl group.