Patent ID: 8664443
Filing Date: 2014-03-04
Classification: C07C,C07D

Abstract:
1. A process for the preparation of (1S,3S,5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile of Formula-I, which comprises the debenzylation of benzyl N-[(1S)-2-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl]-1-(3-hydroxyadamantan-1-yl)-2-oxoethyl] carbamate of Formula-XI, by dissolving in a suitable solvent and reacting with a hydrogen source in the presence of a metal catalyst