Patent ID: 9207247
Filing Date: 2015-12-08
Classification: G01N

Abstract:
1. A method of diagnosing hip osteoarthritis in a test subject suspected of having osteoarthritis, said method comprising: i) obtaining a serum sample from the test subject. ii) quantitating a total amount of COMP protein fragments that comprise an amino acid sequence consisting of SEQ ID NO: 3 by contacting the serum sample with an antibody or antigen-binding fragment thereof that specifically recognizes SEQ ID NO: 3 to form a complex, wherein the antibody is produced by a hybridoma having a deposit accession number selected from the group consisting of PTA-11688, PTA-11690, PTA-11686, and PTA-11687; and iii) comparing the total amount of COMP protein fragments quantitated in step (ii) to a control level of COMP protein fragments that comprise the amino acid sequence consisting of SEQ II) NO: 3, wherein the control level is calculated in a serum sample obtained from an age matched sample from subjects not having hip osteoarthritis, and wherein a statistically significant increase of COMP protein fragments in step (ii) in the sample from the test subject relative to the control level is indicative of hip osteoarthritis in the test subject.