Patent ID: 8653065
Filing Date: 2014-02-18
Classification: A61K,A61P

Abstract:
1. A method for forming a drug substance consisting essentially of A-B-C wherein A is a pharmaceutically active compound; C is an amine and B is a bidentate linking group comprising: mixing at least two moles of said pharmaceutically active compound or said amine with a mole of pamoic acid or a salt thereof thereby forming a conjugate; and mixing 0.9 to 1.1 moles of other of said amine or said pharmaceutically active compound with said conjugate thereby forming said A-B-C selected from the group consisting of: amorphous racemic-methylphenidate pamoate characterized by at least one method selected from the group consisting of: polymorphic racemic-methylphenidate stearylamine pamoate characterized by at least one method selected from the group consisting of: amorphous d-methylphenidate pamoate characterized by at least one method selected from the group consisting of: polymorphic d-methylphenidate pamoate characterized by at least one method selected from the group consisting of: polymorphic racemic-methylphenidate pamoate characterized by at least one method selected from the group consisting of: amorphous dextro-amphetamine pamoate characterized by at least one method selected from the group consisting of: polymorphic dextro-amphetamine pamoate characterized by at least one method selected from the group consisting of: amorphous d-methylphenidate mono-triethylammonium pamoate characterized by at least one method selected from the group consisting of: amorphous imipramine mono-triethylammonium pamoate characterized by an PXRD diffractogram of polymorphic imipramine stearylamine pamoate characterized by at least one method selected from the group consisting of: amorphous imipramine, CH amorphous hydrocodone stearylamine pamoate characterized by at least one method selected from the group consisting of: amorphous hydrocodone, CH polymorphic imipramine pamoate (1:1) characterized by at least one method selected from the group consisting of: amorphous imipramine pamoate (1:1) characterized by at least one method selected from the group consisting of: