Patent ID: 6358613
Filing Date: 2002-03-19
Classification: B05D,B82Y,G01N,Y10T

Abstract:
A silicon substrate having a surface comprising a covalently bound monolayer, said monolayer comprising a substituted or unsubstituted vinyl or alkyl group of the formula: whereinSi is a surface silicon atom through which the substituted or unsubstituted vinyl or alkyl group is bonded to the silicon surface; x represents a single or double bond; when x is a double bond, n is 0; when x is a single bond, n is 1; and R1 and R3 independently, are hydrogen or C1-C4 alkyl or R1 and R3, together with the carbon atoms to which they are attached, form a 5-, 6-, 7- or 8-membered ring, or R1 is hydrogen and R3 is BH2 or B(OH)2, or R1 is BH2 or B(OH)2, and R3 is hydrogen; R2 and R4 independently, are hydrogen or optionally substituted C1-C18 alkyl, aryl or heteroaryl, and when R2 or R4 is a substituted group, the group is substituted with one or more substituents from the group consisting of hydroxy, halo, cyano, aryl, heteroaryl, C1-C18 alkoxy, carboxy, phospho, phosphino, C1-C18 alkoxycarbonyl, primary, secondary or tertiary amino, carbamido, thiol, or C1-C18 alkylthio, ferrocene or another electron donor, a metal chelating ligand or a metal complex thereof, or a biologically significant ligand selected from an antibody, a receptor protein, DNA or RNA, or a DNA or RNA analog capable of forming a double or triple stranded complex with DNA or RNA; or R2 and R4, together with the carbon atoms to which they are attached, form a 5-, 6-, 7- or 8-membered ring.