Patent ID: 8686045
Filing Date: 2014-04-01
Classification: A61K,A61P,C07C,C07K

Abstract:
1. A method of treating a disorder in a subject in need thereof, comprising administering to the subject an effective amount of a compound that is an agonist or partial agonist of a TrkB receptor, thereby treating the disorder, wherein the compound is a small molecule mimetic of a brain-derived neurotrophic factor (BDNF) β-turn loop, wherein the β-turn loop is loop 2, and the small molecule mimetic has a structure of Formula (II): or a pharmaceutically acceptable salt thereof; wherein: L L Y X Z D and wherein the disorder is selected from the group consisting of Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, Rett syndrome, Parkinson's disease, spinal cord injury, stroke, ischemia, brain injury, motor neuron disease, multiple sclerosis, HIV dementia, peripheral nerve injury, hearing loss, and obesity.