Patent ID: 6277967
Filing Date: 2001-08-21
Classification: C07H,C12N

Abstract:
A compound comprising a plurality of covalently-bound 2'-modified nucleosides having the formula: ##STR12##wherein:each B is a nucleobase;one of X.sub.1 or X.sub.2 is O, and the other of X.sub.1 or X.sub.2 is S;each R.sub.1 is F, or a group of formula Z--R.sub.22 --(R.sub.23).sub.v ;Z is O, S, NH, or N--R.sub.22 --(R.sub.23).sub.v ;R.sub.22 is C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl, or C.sub.2 -C.sub.20 alkynyl;R.sub.23 is hydrogen, amino, halogen, hydroxyl, thiol, keto, carboxyl, nitro, nitroso, nitrile, trifluoromethyl, trifluoromethoxy, O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aryl, S-aryl, NH-aryl, O-aralkyl, S-aralkyl, NH-aralkyl, amino, N-phthalimido, imidazole, azido, hydrazino, hydroxylamino, isocyanato, sulfoxide, sulfone, sulfide, disulfide, silyl, aryl, heterocycle, carbocycle, intercalator, reporter molecule, conjugate, polyamine, polyamide, polyalkylene glycol, or polyether;v is from 0 to about 10;or R.sub.1 has one of the formulas: ##STR13##wherein:y1 is 0 or 1;y2 is 0 to 10, provided that y1 and y2 are not simultaneously 0;y3 is 1 to 10;E is N(R.sub.41)(R.sub.42) or N.dbd.C(R.sub.41)(R.sub.42);each R.sub.41 and each R.sub.42 is independently H, C.sub.1 -C.sub.10 alkyl, a nitrogen protecting group, or R.sub.41 and R.sub.42 taken together form a nitrogen protecting group; or R.sub.41 and R.sub.42 taken together with the N or C atom to which they are attached form a ring structure that can include at least one heterotom selected from N and O;n is from 2 to 50; andm is 0 or 1.