Patent ID: 6929919
Filing Date: 2005-08-16
Classification: A01K,A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method for identifying a compound that is useful in treating a neuropsychiatric or neurodevelopmental disorder, which method comprises: (a) contacting a reconstituted system for measuring the interaction of a presenilin associated membrane protein (PAMP) and a PAMP substrate, comprising a PAMP, or a functional fragment thereof, and a PAMP substrate, with a test compound, the PAMP comprising an amino acid sequence at least 90% identical to at least one amino acid sequence selected from the group consisting of SEQ ID NO:14, SEQ ID NO:16 and SEQ ID NO:18; and (b) detecting a difference in the interaction of a PAMP and a PAMP substrate in the presence of the compound compared to the interaction of a PAMP and a PAMP substrate in the absence of the compound, wherein a decrease in the interaction of a PAMP and a PAMP substrate identifies the candidate compound.