Patent ID: 6420341
Filing Date: 2002-07-16
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating vasoconstrictor and hypertension effects in warm-blooded animals comprising administering to warm-blooded animals an amount sufficient to inhibit vasoconstrictor and hypertension effects of a compound of the formula wherein R1 is unsubstituted or substituted phenyl or biphenyl, the substituents being at least one member of the group consisting of hydroxy, protected hydroxy, alkoxy of 1 to 4 carbon atoms, â€”CN, carboxy, salified carboxy, carboxy esterif ied with alkanol of up to 6 carbon atoms, amidified carboxy, benzyloxy and dioxol, n1 and n2 are individually 0 or 1, R2 is hydrogen or methyl substituted with a member of the group consisting of phenyl, phenylthio and indolyl, all unsubstituted or substituted by phenyl or substituted with at least one member of the group consisting of a) halogen, â€”OH, protected â€”OH, â€”CN, alkoxy of 1 to 4 carbon atoms, carboxy, salified carboxy, carboxy esterified with alkanol of 1 to 6 carbon atoms, amidified carboxy, benzyloxy and b) thienyl, naphthyl and phenyl, each unsubstituted or substituted with at least one member of the group consisting of halogen, â€”OH, protected â€”OH, alkoxy of 1 to 4 carbon atoms, â€”CN, carboxy, salified carboxy, carboxy esterified with alkanol of 1 to 6 carbon atoms and amidified carboxy, A is selected from the group consisting of carboxy, salified carboxy, carboxy esterified with an alkanol of 1 to 6 carbon atoms, amidified carboxy, tetrazolyl, salified tetrazolyl and alkyl of 1 to 10 carbon atoms substituted with a member selected from the group consisting of a) carboxy, salified carboxy, carboxy esterified with an alkanol of 1 to 6 carbon atoms, amidified carboxy, â€”OH, protected â€”OH, alkoxy of 1 to 4 carbon atoms, and b) phenoxy, phenyl, naphthyl, thienyl, indolyl and pyridyl, each unsubstituted or substituted with at least one member of the group consisting of halogen, â€”OH, protected â€”OH, alkoxy of 1 to 4 carbon atoms, â€”CN, carboxy, salified carboxy, carboxy esterified with an alkanol of 1 to 6 carbon atoms and amidified carboxy, 1) and 2) indicating possible asymmetric centers and its addition salts with a non-toxic, pharmaceutically acceptable acid or base.