Patent ID: 6455322
Filing Date: 2002-09-24
Classification: G01N,Y10S

Abstract:
A competition binding assay to identify a P2YADP receptor ligand, which comprises contacting a P2YADP receptor with a P2YADP receptor radioligand and a candidate P2YADP receptor ligand, and measuring reactivity bound to the P2YADP receptor, wherein the radioligand is selected from the group consisting of [125I]-1S-[1a, 2b,3b,4a(E)]]-2,3-dihydroxy-4-[7-(3-iodo-prop-2-enylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentanecarboxylic acid, [3H]-[1S-(1&agr;,2&bgr;,3&bgr;,4&agr;)]-4-[7(butylamino)-5-(propylthio)-3H-1,2,3-triazolo-[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentanepropanoic acid, salts and solvates thereof.