Patent ID: 8022079
Filing Date: 2011-09-20
Classification: A61P,C07D

Abstract:
1. A method for the treatment of common acne, comedones, polymorphous acne, nodulocystic acne, acne conglobata, senile acne or secondary acne, comprising administering to an individual in need of such treatment, an effective PPARγ receptor-activating amount of a compound having the following structural formula (I): in which: R2 is an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a 9-fluorenylmethyl radical or a radical of formula (CH R5, R6, m, n and p are as defined below; R5 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical, R6 is: an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a radical or a radical NR′(CH where R10, R′, R″ and v are as defined below; m has the value 0, 1 or 2; n and p have the value 0 or 1; v has the value 1, 2 or 3; R10 is an alkyl radical having from 1 to 12 carbon atoms, an aryl, aralkyl, heteroaryl or heterocyclic radical, a radical NH—CO—R12, a radical NH—CO—O—R12 or C—R12R13 or a radical N—R12R13, wherein R12 and R13 are as defined below; R″ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, a heteroaryl radical or a heterocyclic radical; R″ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, optionally substituted with one or more halogens, a heteroaryl radical, a heterocyclic radical, a radical (CH R12 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R13 is a hydrogen atom or an alkyl radical having from 1 to 12 carbon atoms; T is an oxygen or sulfur atom; and Ar1 and Ar2, which may be identical or different, are each an optionally substituted aromatic radical of one of the formulae: wherein A is an S or O atom or a radical N—R13, with the proviso that, when Ar1 or Ar2 is a  radical, then Ar2 or Ar1 is not a  radiacal, or an optical or geometrical isomer or salt thereof.