Patent ID: 6048854
Filing Date: 2000-04-11
Classification: C07C,C07D

Abstract:
A compound of the formula (1): ##STR202## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a cycloalkyl group, a lower alkenyl group, a lower alkynyl group, an aryl group, a heterocyclic group, a substituted lower alkyl group, a substituted cycloalkyl group, a substituted lower alkenyl group, a substituted lower alkynyl group, a substituted aryl group or a substituted heterocyclic group;R.sup.2 is a lower alkyl group, a cycloalkyl group, a lower alkenyl group, a lower alkynyl group, an aryl group, a heterocyclic group, a substituted lower alkyl group, a substituted cycloalkyl group, a substituted lower alkenyl group, a substituted lower alkynyl group, a substituted aryl group or a substituted heterocyclic group;A.sup.1 is --CO-- or --CO--A.sup.4 -- (wherein A.sup.4 is a residue of an .alpha.-amino acid, an .alpha.-amino acid derivative, a .beta.-amino acid or a .beta.-amino acid derivative, or a residue of a peptide consisting of 2 or 3 residues thereof);A.sup.2 and A.sup.3 are the same or different and each a single bond, --NR.sup.6 -- (wherein R.sup.6 is a hydrogen atom or a lower alkyl group), an oxygen atom, S(O).sub.n (wherein n is 0, 1 or 2), --CO--NR.sup.7 -- (wherein R.sup.7 is a hydrogen atom or a lower alkyl group), --NR.sup.7 --CO-- (wherein R.sup.7 is the same as defined above), --CO--A.sup.5 --NR.sup.8 -- (wherein R.sup.8 is a hydrogen atom or a lower alkyl group, A.sup.5 is a residue of an .beta.-amino acid, an .alpha.-amino acid derivative, a .beta.-amino acid or a .beta.-amino acid derivative, or a reside of a dipeptide consisting of 2 residues thereof), --NR.sup.8 --A.sup.5 --CO-- (wherein R.sup.8 and A.sup.5 are the same as defined above), a divalent group of a monocyclic hydrocarbons or a divalent group of a monocyclic heterocyclic group;R.sup.3, R.sup.4 and R.sup.5 are the same or different and each a single bond, or an alkylene, alkenylene or alkynylene group, which may optionally be substituted by 1 to 4 groups selected from the hydroxy group, an oxo group, a halogen atom, an aryl group and a cycloalkyl group, provided that when A.sup.2 and A.sup.3 are the same or different and each --NR.sup.6 -- (wherein R.sup.6 is the same as defined above), an oxygen atom or S(O).sub.n (wherein n is the same as defined above), R.sup.4 should not be a single bond;the definition for X and the number of atoms comprising a divalent main chain represented by --R.sup.5 --A.sup.3 --R.sup.4 --A.sup.2 --R.sup.3 --A.sup.1 -- are shown in the following (a):(a) X is a group of the formula (4): ##STR203## wherein Y.sup.2 and Y.sup.3 are the same or different and each a methine group or a nitrogen atom, V.sup.3 is a hydrogen atom, an alkyl group, a substituted lower alkyl group, a cycloalkyl group, an amino group, an acylamino group, a lower alkyloxycarbonyl group or a lower alkyloxycarbonyl group substituted by an aryl group, m is 2 or 3, and the number of atoms comprising a divalent main chain represented by --R.sup.5 --A.sup.3 --R.sup.4 --A.sup.2 --R.sup.3 --A.sup.1 -- is 4 to 9,or a pharmaceutically acceptable salt thereof.