Patent ID: 6011038
Filing Date: 2000-01-04
Classification: C07D

Abstract:
A compound having the formula: ##STR42## wherein W isR.sup.2 CF.sub.2 C(R.sup.12)2;R.sup.2 and R.sup.14 are independentlyphenyl, unsubstituted or substituted with one or more of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R', where R' is C.sub.1-4 alkyl, or SO.sub.2 NH.sub.2,naphthyl,biphenyl,C.sub.1-7 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,halogen,amino,phenyl,naphthyl,C.sub.3-7 cycloalkyl,CF.sub.3,N(CH.sub.3).sub.2,--C.sub.1-3 alkylphenyl, or--C.sub.1-3 alkylnaphthyl,CF.sub.3C.sub.3-7 cycloalkyl, unsubstituted, monosubstituted with halogen, phenyl or naphthyl, or disubstituted with halogen,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl;R.sup.3 ishydrogen,C.sub.1-4 alkyl,C.sub.3-7 cycloalkyl, ortrifluoromethyl;X is hydrogen or halogen;A is chosen from one of the following radicals: ##STR43## wherein Y.sup.1 and Y.sup.2 are independently hydrogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,C.sub.3-7 cycloalkyl,halogen, ortrifluoromethyl;R.sup.4 ishydrogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,halogen,--OCH.sub.2 CF.sub.3,--OCH.sub.2 CN,--COOH,--OH,--COOR.sup.6, where R.sup.6 is C.sub.1-4 alkyl,--CONR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are independently hydrogen or C.sub.1-4 alkyl,--(CH.sub.2).sub.1-4 OH,--CH.sub.2 NHC(O)CH.sub.3,--CH.sub.2 NHC(O)CF.sub.3,--CH.sub.2 NHSO.sub.2 CH.sub.3,--SO.sub.2 NH.sub.2,--(CH.sub.2).sub.1-4 SO.sub.2 NR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are as defined above,--(CH.sub.2).sub.1-4 SO.sub.2 R.sup.6, where R.sup.6 is as defined above,--ZCH.sub.2 CO.sub.2 H,--ZCH.sub.2 CO.sub.2 CH.sub.3,--ZCH.sub.2 R.sup.14,--ZCH.sub.2 NHR.sup.14,--ZCH.sub.2 CO.sub.2 (CH.sub.2).sub.1-3 CH.sub.3,--Z(CHR.sup.9).sub.1-3 C(O)NR.sup.10 R.sup.11,whereinR.sup.9 is H or C.sub.1-4 alkyl,R.sup.10 and R.sup.11 are independentlyhydrogen,C.sub.3-7 cycloalkyl,phenyl,naphthyl,--(CH.sub.2).sub.1-2 NCH.sub.2 CH.sub.3,C.sub.1-4 alkyl unsubstituted or substituted with one or more of:hydroxy,COOH,amino,phenyl, ornaphthyl,R.sup.10 and R.sup.11 are joined to form a four to seven membered cycloalkyl ring unsubstituted or substituted with hydroxy, amino or phenyl or naphthyl or disubstituted with hydroxy,wherein Z is O, S or CH.sub.2 ;R.sup.5 ishydrogen,halogen ,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,CF.sub.3,CN, orCO.sub.2 NH.sub.2 ; andR.sup.12 ishydrogen,phenyl, unsubstituted or substituted with one or more Of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, COOH, CONH.sub.2,naphthyl,biphenyl,C.sub.1-4 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,amino,phenyl, ornaphthyl,CF.sub.3,C.sub.3-7 cycloalkyl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkylor a pharmaceutically acceptable salt thereof.