Patent ID: 7459443
Filing Date: 2008-12-02
Classification: A61K,C12N,C12P

Abstract:
1. A process for making medicaments to treat cancer diseases at metastasis stage and diseases caused by viruses, the process comprising template directed assembling of biologically inactive precursors, in target cancer cells or cells infected by viruses, so as to synthesize biologically active compounds in said target cells, wherein the biologically active compounds are synthesized by the process comprising: using a composition comprising at least two different oligomers chemically bound at their 5′ and/or 3′ end via a linking moiety to said biologically inactive precursors of biologically active compound, and said biologically inactive precursors comprising chemically active groups wherein said oligomers allow the hybridization to a cellular RNA, DNA or dsDNA such that after hybridisation the distance between the 3′ or 5′ ends of said two oligomers coupled to the biologically inactive precursors is in the range of 0 to 8 ribo(deoxy)nucleotides and said hybridization leads to a chemical coupling of said two precursors via said chemically active groups and/or said linking moieties and the intracellular synthesis of said biologically active compound in the target cells.