Patent ID: 8623395
Filing Date: 2014-01-07
Classification: A61F,A61K,A61M,A61P,C07K

Abstract:
1. An ophthalmic drug delivery system comprising: an extended release device configured to be implanted in an eye, the device comprising: a reservoir having a reservoir volume; and a rigid porous structure coupled to the reservoir and having a release rate index (RRI)=PA/FL, where P is porosity corresponding to the percentage of void space of channels extending within the rigid porous structure, A is area, F is channel parameter, and L is thickness, the rigid porous structure having a plurality of irregularly shaped channels, the porous structure located at the outlet of the reservoir and tuned to release a predetermined rate profile of a drug formulation from the reservoir through the plurality of channels and into the eye to treat the eye for an extended period of time; and a drug formulation contained in and delivered by the extended release device, wherein the drug formulation comprises a drug having a concentration in a solution volume and a given half-life upon bolus injection of the solution volume into an eye, wherein the extended release device is tuned to the drug formulation by selecting a value for at least one of the group consisting of: the concentration, the reservoir volume, and the RRI, to achieve an effective half-life in the eye when the drug formulation is delivered by the implantable extended release device, wherein the effective half-life is longer than the given half-life; and wherein the porosity P is between about 3% to about 70%, area A is between about 0.37 mm2 to about 16 mm2, channel parameter F is within a range of about 1.2 to 5.0 times the thickness of the porous structure, and thickness L is between about 0.029″ to about 0.049″.