Patent ID: 8835115
Filing Date: 2014-09-16
Classification: C12Q

Abstract:
1. A method for identifying a human subject at increased risk for developing microtubule-stabilizing-agent-induced adverse effects selected from the group consisting of neutropenia and peripheral neuropathy, comprising: amplifying DNA isolated from a biological sample obtained from a human subject having a tumor that can be treated with a microtubule-stabilizing-agent or a subject who has been treated with a microtubule-stabilizing-agent using primer sequences selected from the group consisting of SEQ ID NOS: 3, 4, 5 and 6; determining in a biological sample obtained from a human subject having a tumor that can be treated with a microtubule-stabilizing-agent or a subject who has been treated with a microtubule-stabilizing-agent that the human subject has a 2677G>T (Ala893Ser) and a 3435C>T (synonymous) predictive polymorphism in an ABCB1 gene, wherein the primer sequences consisting of SEQ ID NOS: 9 and 10 are used to detect 2677G>T and the primer sequences consisting of SEQ ID NOS: 11 and 12 are used to detect 3435C>T; and identifying the subject as one at increased risk for developing microtubule-stabilizing agent-induced adverse effects selected from the group consisting of neutropenia and peripheral neuropathy as compared to a subject which does not have the 2677G>T (Ala893Ser) and 3435C>T (synonymous) predictive polymorphisms.