Patent ID: 6660719
Filing Date: 2003-12-09
Classification: A61K

Abstract:
A process for enhancing the inhibition of T-cell proliferation in a mammalian host in need thereof by administering to said boat an enhanced effective amount of 2â€²-deoxyguanosine, and at least one PNP inhibitor having a Ki of 500 picomolar or less and wherein said at least one PNP inhibitor comprises at least one compound represented by the formula: wherein A is CH or N; B is selected from the group consisting of OH, NH2, NHR, H or halogen; D is selected from the group consisting of OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from the group consisting of H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof.