Patent ID: 7033598
Filing Date: 2006-04-25
Classification: A61N

Abstract:
1. A method of delivering a biologically active agent to the central nervous system (CNS) of a mammal utilizing pathways that bypass blood-brain barrier comprising the steps of: (a) establishing a source of the agent at a zone adjacent a mammal body surface area, the zones being selected from the group consisting of olfactory region, ocular region, brain surface, spinal cord, and intrabrain, (b) establishing a radiant energy gradient from the source to CNS and maintaining the gradiant by energy supply to drive the agent directly from the source to and into the CNS region adjacent the source and within CNS essentially bypassing the mammal's blood-brain barrier, the biological agent being selected of a species and size responsive to the radiant energy driving force and mobile within its selected pathway to and within CNS, but larger than sizes of agents that readily traverse blood-brain barrier.