Patent ID: 6013839
Filing Date: 2000-01-11
Classification: C07C

Abstract:
A process for preparing a 2-(thiosubstituted)-4-haloacetophenone of formula (I): ##STR5## wherein R.sup.1 is lower alkyl, or phenyl which is unsubstituted or substituted by from one to five groups which are the same or different selected from the group consisting of halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy and --S(O).sub.n R.sup.5 ;R.sup.2 is hydrogen, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy or --S(O).sub.n R.sup.5 ;R.sup.3 is halogen; n is zero, one or two;R.sup.5 is lower alkyl or phenyl which is unsubstituted or substituted by from one to five groups which are the same or different selected from the group consisting of halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy and --S(O).sub.n -alkyl;said process comprising reacting a 2,4-dihaloacetophenone of formula (II): ##STR6## wherein R.sup.2 and R.sup.3 are as defined above and R.sup.4 is halogen; with a thiolating agent of formula (III):R.sup.1 S--X (III)wherein R.sup.1 is as defined above and X is hydrogen or a metal cation;under substantially anhydrous conditions in which the volume of water present is less than about 1 percent.