Patent ID: 8921412
Filing Date: 2014-12-30
Classification: A61P,C07D

Abstract:
1. A compound of formula I, or a pharmaceutically acceptable salt or a prodrug thereof: wherein, X is methylene or cyclopropane; ring A is benzene, naphthalene, or indole; ring B is said ring D being C ring C is a macrocycle formed by connecting ansa bridge between the tetrahydropyran ring and ring A; and n is an integer of 5 to 10, wherein, said ring A and ring B are each independently optionally substituted with at least one selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, cyano, nitro, amino, carboxy, C said R said alkyl, alkenyl, alkynyl, or alkoxy is optionally substituted with at least one selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C said cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycloalkyl is optionally substituted with at least one selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C