Patent ID: 6600038
Filing Date: 2003-07-29
Classification: A61K,A61P,C07D

Abstract:
A carbamoyl tetrahydropyridine derivative represented by the formula: wherein: R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-C5 alkyl group, or a phenyl group, or alternatively, R1 and R2, taken together with the nitrogen atom to consisting of a pyrrolidino group, a piperidino group, a morpholino group, a thiomorpholino group, a piperazino group, and a 4-methylpiperazino group; R3 represents a hydrogen atom or a C1-C5 alkyl group; Y1-Y2 represents (R4)C&boxH;C(R5), (R6)C&boxH;N, N&boxH;N, (R7)Nâ€”CO, or N&boxH;C(R8); X1, X2, and X3 are identical or different, and each represents a hydrogen atom, a halogen atom, a C1-C5 alkyl group, a C1-C5 alkoxy group, a C1-C5 alkylthio group, a trifluoromethyl group, a trifluoromethoxy group, an amino group, or a C1-C5 alkylamino group; wherein R4 and R5 are identical or different, and each represents a hydrogen atom or a C1-C5 alkyl group; R6 represents a hydrogen atom or a C1-C5 alkyl group; R7 represents a hydrogen atom, a C1-C5 alkyl group, a (C1-C5 alkoxy)carbonylmethyl group, a carboxymethyl group, or a group represented by the formula: CH2CONR11(R12), wherein R11 and R12 are identical or different, and each represents a hydrogen atom or a C1-C5 alkyl group, or alternatively, R11 and R12, taken together with the nitrogen atom to which they are adjacent, represent a saturated heterocyclic group selected from the group consisting of a pyrrolidino group, a piperidino group, a morpholino group, a thiomorpholino group, a piperazino group, and a 4-methylpiperazino group; and R8 represents a hydrogen atom or a carbamoyl group; or a pharmaceutically acceptable salt thereof.