Patent ID: 8716215
Filing Date: 2014-05-06
Classification: A61K,A61P,G01N

Abstract:
1. A method of treating or reducing deterioration of, injury to, or damage to a subject's tissue that is caused by at least one disease selected from a neuro-, muscular- or neuro-muscular-degenerative disease other than Duchenne muscular dystrophy, or restoring said subject's tissue that has been adversely affected by said at least one disease, comprising administering to said subject an effective amount of a composition comprising a peptide agent comprising amino acid sequence LKKTET (SEQ ID NO: 1) or a conservative variant thereof, Thymosin β4 (Tβ4), KLKKTET (SEQ ID NO: 3) or a conservative variant thereof, LKKTETQ (SEQ ID NO: 4) or a conservative variant thereof, so as to treat or reduce tissue deterioration, injury or damage caused by said at least one disease, or to restore tissue adversely affected by said at least one disease, wherein said disease is associated with an inflammatory disorder in said subject or wherein said disease comprises an inflammatory disorder in said subject, and wherein said disease is at least one of a disease of neurovascular cells or nervous tissue other than brain neurovascular cells or nervous tissue, multiple sclerosis (MS), spinal muscular atrophy (SMA), myasthenia gravis, transmissible spongiform encephalopathies (TSEs), bovine spongiform encephalopathy (BSE) or muscular dystrophy other than Duchenne muscular dystrophy.