Patent ID: 7666582
Filing Date: 2010-02-23
Classification: A61K,C07K,C12N

Abstract:
1. A method of generating Fc or Fab fragments of IgG comprising: (i) contacting IgG with: wherein said polypeptide (a) and said polypeptide (b) have a cysteine residue at the position corresponding to position 65 of SEQ ID NO:1, position 65 of SEQ ID NO:1 corresponding to position 94 of SEQ ID NO:2, wherein IgG is contacted with said polypeptide (a) or said polypeptide (b) under conditions that permit the IgG specific cysteine protease activity of said polypeptide (a) or said polypeptide (b); (ii) thereby generating said fragments of IgG; and (iii) isolating the fragments of IgG obtained, or analysing the starting materials or reaction products to determine whether the desired product is present.