Patent ID: 8337830
Filing Date: 2012-12-25
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method to increase survival, reduce tumor burden, or inhibit tumor growth in a patient that has cancer, comprising the combination of the steps of: a) establishing a stable mixed bone marrow chimerism in a patient that has cancer by nonmyeloablative stem cell transfer, wherein the stem cells are provided by an allogeneic donor; b) administering lymphocytes obtained from the allogeneic donor to the patient; and c) administering to the patient, after step (b) and prior to detection of tumor response in the patient, a composition comprising a yeast vehicle and at least one cancer antigen or immunogenic domain thereof, wherein the cancer antigen or immunogenic domain thereof is expressed by the cancer for which the patient is treated.