Patent ID: 6140331
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A fused benzo compound having the formula ##STR12## wherein A is a 2 to 6 membered spacer group selected from alkylene, alkenylene, and alkynylene which optionally may be branched chain when A is a 3 to 6 membered spacer, or straight chain, or a 3-7 membered cycloalkylene group, said spacer group being optionally substituted with aryl or hydroxy;B is a polar divalent group selected from the group consisting of SO, SO.sub.2, and a group having the formula, ##STR13## wherein W is O or S, and Z is selected from the group consisting of --(CH.sub.2).sub.n --, ##STR14## said phenylene being optionally substituted with halogen or trifluoromethyl;U is N; the dotted line designates an optional double bond;wherein X is selected from the group of divalent 4-membered groups consisting of ##STR15## wherein the dotted lines indicate optional double bonds; thereby forming a heterocyclic ring fused with the benzene ring;R.sup.1 is alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenyl, cycloalkylalkyl, cycloalkenylalkyl, cycloalkylalkenyl, cycloalkenylalkenyl, cycloalkylalkynyl, cycloalkenylalkynyl, phenylalkyl, or diphenylalkyl; wherein any alkyl group optionally may be substituted with one or two hydroxy groups, with the proviso that if Z is 1,2-phenylene, then R.sup.1 is selected from phenyl and substituted phenyl; R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl or they may be linked together, to form an ethylene or propylene bridge; R.sup.4, R.sup.5, and R.sup.6 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, hydroxy, lower alkylthio, lower alkylamino, di-lower-alkylamino, cyano, nitro, trifluoromethyl and trifluoromethylthio; R.sup.7 and R.sup.8 are independently selected from the group consisting of hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkyl substituted with one or more hydroxy groups, aryl, cyano, --COOR.sup.9 and --CONR.sup.10 R.sup.11, R.sup.9, R.sub.10, and R.sup.11 are hydrogen or lower alkyl; any phenyl group present optionally may be substituted with one or more substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, lower alkylsulfonyl, lower alkylamino, lower dialkylamino, cyano, trifluoromethyl and trifluoromethylthio; and pharmaceutically acceptable acid addition salts thereof.