Patent ID: 6699864
Filing Date: 2004-03-02
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR7 and R8 independently represent hydrogen, halogen, C1-6-alkyl; or R7 and R8 together form a pyridyl-ring fused to the benzene ring; R6 and R6â€² represent H or C1-6-alkyl; X represents -O- or -S-; n is 2, 3, 4 or 5; R1, R2, R3, R4 and R5 are independently selected from a group consisting of hydrogen, halogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, aryl, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkoxy, C1-6-alkylsulfanyl, acyl, NR9R10 wherein R9 and R10 independently represent hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl aryl, hydroxy, hydroxyl C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkoxy, C1-6-alkylsulfanyl, acyl, NR9R10 wherein R9 and R10 independently represent hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl or aryl; or R9 and R10 together with the nitrogen to which they are attached form a 1-morpholinyl, 1-piperidinyl, 1-homopiperidinyl, 1-piperazinyl, 1-homopiperazinyl, 1-imidazolyl, 1-pyrrolyl, or pyrazolyl, all of which may be further substituted with C1-6-alkyl; or two adjacent substituents of R1- R5 together form a ring fused to the phenyl ring selected from the group consisting of: wherein W is O or S, and Râ€² and Râ€³ are hydrogen or C1-6-alkyl; or a pharmaceutically acceptable acid addition salt thereof.