Patent ID: 8921572
Filing Date: 2014-12-30
Classification: C07D

Abstract:
1. A process for preparing 5,5-disubstituted 4,5-dihydroisoxazole-3-thiocarboxamidine salts of the formula (I) where R R R A is chlorine or bromine; comprising i) reacting a compound of formula (II) with a chlorinating or brominating reagent to give a compound of formula (III) ii) reacting the compound of formula (III) with thiourea to give the compounds of the formula (I); wherein the compound of formula (II) is prepared in a preliminary stage by reaction of a compound of formula (AII) wherein R with a compound of formula (AIII) in the presence of an acid catalyst or of an acid-base catalyst and optionally in the presence of an organic solvent.