Patent ID: 7930157
Filing Date: 2011-04-19
Classification: G01N,G16B

Abstract:
1. A polypeptide synthesiser comprising a computer system for determining a rate of aggregation of a second polypeptide in relation to a reference polypeptide, wherein said reference polypeptide is defined by said reference polypeptide sequence, and wherein said second polypeptide amino acid sequence comprises a modified version of said reference polypeptide sequence, the computer system comprising: a data store for storing data comprising hydrophobicity data, β-sheet propensity data and charge data for a set of amino acids; a program store storing computer program code; and a processor, coupled to said program store and to said data store for implementing said stored code, and wherein said code further comprises code for controlling the processor to: input said second polypeptide amino acid sequence; determine a relative rate of aggregation for said second polypeptide by