Patent ID: 9011823
Filing Date: 2015-04-21
Classification: A61K,A61Q

Abstract:
1. A method of enhancing the cariostatic effect of fluoride on oral tissue, teeth and dental plaque in an oral cavity comprising the steps of: delivering, in a first delivery vehicle, an amount of a soluble calcium compound into the oral cavity, wherein the first delivery vehicle has a soluble calcium concentration of at least about 30 mMol/L; allowing calcium ions released from the soluble calcium compound to migrate to and penetrate into the oral tissue, teeth and dental plaque within the oral cavity for a sufficient delay period for solubilized calcium to be cleared from the oral cavity by swallowing or expectoration; and following the delay period, delivering, in a second delivery vehicle, a soluble fluoride-containing compound into the oral cavity whereby said calcium ions react with soluble fluoride ions released from the fluoride-containing compound in the oral cavity to form calcium-bound fluoride deposits on teeth, and in the oral tissue and dental plaque.