Patent ID: 6290959
Filing Date: 2001-09-18
Classification: A61K,C07K,G01N

Abstract:
A method for screening and testing compounds useful for treatment of urinary tract infection, comprising:incubating uroplakin Ia and/or uroplakin Ib with a labeled microorganism expressing type I fimbriae which bind to uroplakin Ia and/or uroplakin Ib, in the presence or absence of a compound to be tested; measuring an amount of labeled microorganism bound to said uroplakin Ia and/or Ib in the presence of said compound relative to in the absence of said compound, whereby the lower the amount of labeled microorganism bound to said uroplakin Ia and/or Ib, the better the inhibition of binding and the more likely that said compound is useful for the treatment of urinary tract infection; andobtaining any compound found likely to be useful for the treatment of urinary tract infection in said measuring step.