Patent ID: 6600037
Filing Date: 2003-07-29
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (1): whereinR1 is a â€”XR6 group; X is a covalent bond, â€”Oâ€”, â€”Sâ€”, â€”C(O)â€”, â€”C(S)â€”, â€”C(O)Oâ€”, â€”S(O)â€”, S(O2)â€”, â€”CH2â€”, or â€”N(R7)â€”; R7 is a hydrogen atom or a straight or branched alkyl group; R6 is a hydrogen or halogen atom or an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group, or a â€”NO2, â€”CN, â€”SO2N(R8)(R9), â€”CON(R8)(R9), â€”CSN(R8)(R9), â€”NH2 or substituted amino group; R8 and R9, which may be the same or different are a hydrogen atom or an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; R2 and R3 are each a hydrogen atom; R4 is a X1R11 group; X1 is a covalent bond or a â€”C(R12)(R13)â€” or â€”C(O)â€” group; R12 and R13 are each a hydrogen or halogen atom or a hydroxyl, alkyl or haloalkyl group; R11 is an optionally substituted phenyl, thienyl, thiazolyl or indolyl group; R5 is a halogen atom or an alkynyl group; and the salts, solvates, hydrates and N-oxides thereof.