Patent ID: 6774242
Filing Date: 2004-08-10
Classification: C07C,C07D

Abstract:
A process for preparing compounds of general formula I, in which HETN is an indol-1-yl and R1, R2, R3, R4, and R5 are independently hydrogen, nitro, cyano, alkoxycarbonyl with up to 5 carbon atoms, aldehyde, alkylcarbonyl with up to 5 carbon atoms, arylcarbonyl, or amide, provided that R1, R2, R3, R4, and R5 are not all hydrogen atoms, the process comprising:reacting an aromatic aza-heterocycle with a compound of general formula XIV, â€ƒwherein HAL is halogen, and R1, R2, R3, R4, and R5 are as defined above, at a temperature between room temperature and about 80Â° C., inclusive, and in the presence of cesium carbonate and one or more dipolar aprotic solvents, wherein the aromatic aza-heterocycle is an indole.