Patent ID: 8563720
Filing Date: 2013-10-22
Classification: A61P,C07D

Abstract:
1. A method for preparing a thioester compound, comprising a step of reacting a 4-[(4-methyl-1-piperazinyl)methyl]benzoic acid compound represented by the following formula (2) with a 2,2′-dibenzothiazolyl disulfide derivative represented by the following formula (5) in a reaction solvent selected from the group consisting of tetrahydrofuran, halogenated hydrocarbon, aromatic hydrocarbon, and mixtures thereof, in the presence of a phosphine derivative represented by the following formula (6), thereby preparing a thioester compound represented by the following formula (4): wherein HA represents an acid; n is 0, 1 or 2; R X, Y and Z represent a phenyl group.