Patent ID: 7276524
Filing Date: 2007-10-02
Classification: A61P,C07D,C07F

Abstract:
1. A compound of formula (I) wherein R R R R R R k is 0 or 1, A is selected from C  1,2-cyclopropylene D is selected from C  C  C  the group consisting of C R  wherein the heterocyclic ring optionally has a double bond and n and p are, independently of each other selected from, 0, 1, 2 and 3, with the proviso that n+p≦4, q is 1 or 2, R R R G is selected from  G1, G2, G3, G4 and G5, wherein  Gi represents the residue  wherein r is an integer from 1 to 3 or 0, s is 0 or 1, R  the group consisting of saturated, five- to seven-membered heterocycles, which contain one or two hetero-atoms selected from N, S and O,  the group consisting of monocyclic aromatic five and six-membered heterocycles, which contain one to three hetero-atoms selected from N, S and O and are either bound directly or over a methylene group, and  the group consisting of anellated bi- and tricyclic aromatic or partially hydrogenated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms are selected from N, S and O, and the linkage occurs either over an aromatic ring or a hydrogenated ring, and either directly or over a methylene group, R R  the group consisting of monocyclic aromatic five- and six-membered heterocycles, which contain one to three hetero-atoms selected from N, S and O and are either bound directly or over a methylene group,  the group consisting of anellated bi- and tricyclic aromatic or partially hydrogenated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage occurs either over an aromatic or a hydrogenated ring and either directly or over a methylene group, and  the group consisting of anellated bi- and tricyclic aromatic or partially hydrogenated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms are selected from N, S and O and the linkage occurs either over an aromatic ring or a hydrogenated ring and either directly or over a methylene group, G2 is the residue  wherein the substituents R  is a nitrogen-containing heterocycle bound over the nitrogen atom, the nitrogen-containing heterocycle being selected from  the group consisting of saturated and unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, optionally contain one or two further hetero-atoms selected from N, S and O, and  the group consisting of saturated and unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, optionally contain one or two further hetero-atoms selected from N, S and O, G3 is the residue  and G4 is the residue  wherein Ar G5 is the residue  wherein R aromatic ring systems in the substituents R stereoisomers thereof, mixtures thereof and pharmacologically acceptable acid addition salts.