Patent ID: 6288041
Filing Date: 2001-09-11
Classification: A61P,C07H,C07J,G01N

Abstract:
A sialic acid derivative represented by the following general formula (1AA) or its salt, or a hydrate or a solvate thereof: ##STR700##wherein:R.sup.1 represent a residue of a steroid compound excluding cholestane residue and cholestene residue,R.sup.2 represents hydrogen atom or methyl group,R.sup.3 represents a C.sub.1 -C.sub.6 alkyl group, a group of formula: ##STR701##wherein R.sup.6 and R.sup.7 independently represent hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, hydroxyl group, a group of formula R.sup.8 O-- (wherein R.sup.8 represents a C.sub.1 -C.sub.4 alkyl group, phenyl group, or a phenyl-(C.sub.1 -C.sub.3 alkyl) group), nitro group, amino group, a C.sub.1 -C.sub.4 alkylamino group, a C.sub.2 -C.sub.8 dialkylamino group, or a group of formula R.sup.9 O--CO-- (wherein R.sup.9 represents hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, phenyl group, or a phenyl-(C.sub.1 -C.sub.3 alkyl) group), and l represents an integer of 0-6; a group of R.sup.10 O(CH.sub.2).sub.m -- (wherein R.sup.10 represents hydrogen atom; a C.sub.1 -C.sub.4 alkyl group; phenyl group which may optionally have one or more substituents selected from the group consisting of a C.sub.1 -C.sub.4 alkyl group, a halogen atom, hydroxyl group, nitro group, amino group, and carboxyl group; or a phenyl-(C.sub.1 -C.sub.3 alkyl) group which may optionally have one or more substituents selected from the group consisting of a C.sub.1 -C.sub.4 alkyl group, a halogen atom, hydroxyl group, nitro group, amino group, and carboxyl group, and in represents an integer of 2-6); or a group of (R.sup.11)(R.sup.12)N(CH.sub.2).sub.n -- wherein R.sup.11 represents hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, and R.sup.12 represents hydrogen atom; a C.sub.1 -C.sub.4 alkyl group; a C.sub.2 -C.sub.7 acyl group; a C.sub.1 -C.sub.4 alkylsulfonyl group; phenylsulfonyl group which may optionally have one or more substituents selected from the group consisting of a C.sub.1 -C.sub.4 alkyl group, a halogen atom, hydroxyl group, nitro group, amino group, and carboxyl group; or a group of R.sup.13 O--CO-- (wherein R.sup.13 represents a C.sub.1 -C.sub.4 alkyl group, phenyl group, or a phenyl-(C.sub.1 -C.sub.3 alkyl) group), and n represents an integer of 2-6,R.sup.4 represents hydrogen atom or a C.sub.2 -C.sub.7 acyl group,R.sup.5 represents a group of R.sup.14 O-- (wherein R.sup.14 represents hydrogen atom or a C.sub.2 -C.sub.7 acyl group) or a group of R.sup.15 NH-- wherein R.sup.15 represents a C.sub.2 -C.sub.7 acyl group, a group of R.sup.16 O(CH.sub.2).sub.p --CO-- (wherein R.sup.16 represents hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, phenyl group, or a phenyl-(C.sub.1 -C.sub.3 alkyl) group, and p represents an integer of 0-4); a C.sub.7 -C.sub.11 aroyl group which may optionally have one or more substituents selected from the group consisting of a C.sub.1 -C.sub.4 alkyl group, a halogen atom, hydroxyl group, nitro group, amino group, and carboxyl group; or a phenyl-(C.sub.1 -C.sub.3 alkyl)carbonyl group which may optionally have one or more substituents selected from the group consisting of a C.sub.1 -C.sub.4 alkyl group, a halogen atom, hydroxyl group, nitro group, amino group, and carboxyl group, andX represents oxygen atom or sulfur atom.