Patent ID: 8957037
Filing Date: 2015-02-17
Classification: A61K,A61P,C12N

Abstract:
1. A method of upregulating a function of or the expression of a Reprogramming factor polynucleotide selected from SEQ ID NOS: 1,2 or 3 in mammalian cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded antisense oligonucleotide 14 to 28 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of said Reprogramming thetor polynucleotide and has at least 90% sequence identity to a reverse complement of said natural antisense polynucleotide comprising 10 to 30 consecutive nucleotides within nucleotides 1 to 993 of SEQ ID NO: 4, 1 to 493 of SEQ ID NO: 5, and 1 to 418 of SEQ ID NO: 6; thereby upregulating a function of and/or the expression of the Reprogramming factor polynucleotide in mammalian cells or tissues in vivo or in vitro.