Patent ID: 7785847
Filing Date: 2010-08-31
Classification: C07D,C12P

Abstract:
1. A process for preparing optically active alkanols of the formula I in which n is an integer from 0 to 5; Cyc is an optionally substituted, mono- or polynuclear, saturated or unsaturated, carbocyclic or heterocyclic ring, and R which process comprises incubating in a medium comprising alkanone of the formula II in which n, Cyc and R an enzyme (E) selected from the class of dehydrogenases, in the presence of reduction equivalents, the compound of the formula II being reduced enzymatically to give the compound of the formula I and the reduction equivalents consumed in the course of the reaction being regenerated by reacting an alcohol to give the corresponding ketone with the aid of the enzyme (E) and removing said ketone at least partially from the reaction medium, and isolating the product (I) formed, and wherein the enzyme (E) has a polypeptide sequence selected from the group consisting of: (i) the amino acid sequence of SEQ ID NO: 2, and an amino acid sequence which is 95% identical to SEQ ID NO: 2, which retains at least 50% of the alcohol dehydrogenase activity, compared to SEQ ID NO: 2.