Patent ID: 6630496
Filing Date: 2003-10-07
Classification: C07D

Abstract:
A compound of the formula: wherein:R1 and R1â€² are independently selected from the group consisting of H, C1-C6 alkyl, â€”Zâ€”C1-C6 alkyl, phenyl, â€”(CH2)nâ€”Zâ€”(CH2)n-phenyl, benzyl, â€”(CH2)nâ€”Zâ€”(CH2)n-benzyl, naphthyl, â€”(CH2)nâ€”Zâ€”(CH2)n-napthyl, pyrimidinyl, and â€”(CH2)nâ€”Zâ€”(CH2)n-pyrimidinyl, wherein the alkyl, phenyl, benzyl, napthyl and pyrimidinyl groups may be optionally substituted by from 1 to 3 substituents selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, â€”NO2, â€”NH2, â€”CN, â€”CF3, and â€”OH; Z is O or S; n is an integer from 0 to 3; R2 is selected from the group consisting of H, halogen, â€”CF3, â€”OH, â€”C1-C10 alkyl, C1â€”C10 alkoxy, â€”CHO, â€”CN, â€”NO2, â€”NH2, â€”NHâ€”C1-C6 alkyl, â€”N(C1-C6 alkyl)2, â€”NHâ€”SO2â€”C1-C6 alkyl, and â€”SO2-C1-C6 alkyl; R3 is selected from the group consisting of H, halogen, â€”CF3, â€”OH, C1-C10 alkoxy, â€”CHO, â€”CN, â€”NO2, â€”NH2, â€”NHâ€”C1-C6 alkyl, â€”N(C1-C6 alkyl)2, â€”NHâ€”SO2â€”C1-C6 alkyl, and â€”SO2â€”C1-C6 alkyl; n in each appearance is independently an integer selected from 0-3; R4 is R12 is selected from the group consisting of H, â€”CF3, C1-C6 alkyl, â€”(CH2)nâ€”C3-C6 cycloalkyl, phenyl, and benzyl, the cycloalkyl, phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from the group consisting of halogen, â€”CF3, â€”OH, â€”COOH, â€”(CH2)nâ€”COOH, â€”(CH2)nâ€”C(O)â€”COOH, â€”C1-C6 alkyl, â€”Oâ€”C1-C6 alkyl, â€”NH(C1-C6 alkyl), and â€”N(C1-C6 alkyl)2; R5 is selected from the group consisting of 4-{[3,5-bis(trifluoromethyl)phenoxy]-methyl}benzyl, 3-[3,5-bis(trifluoromethyl)phenoxy]propyl, 2,4-bis(trifluoromethyl)benzyl, 4-chlorobenzyl, 2-naphthylmethyl, 4-benzylbenzyl, and 3-[3,5-bis(trifluoromethyl)phenoxy]-propyl; provided that R1, R1â€², R2 and R3 are not all H, or a pharmaceutically acceptable salt thereof.