Patent ID: 7838027
Filing Date: 2010-11-23
Classification: A61K,A61P

Abstract:
1. Pantoprazole multiparticulates having reduced release under gastric conditions and fast release at neutral pH, wherein each of said multiparticulates comprises: a spheroid core comprising about 20% w/w to about 45% w/w of a pantoprazole salt or a hydrate thereof, as the sole active component in the multiparticulate and about 25% to about 30% w/w microcrystalline cellulose, about 4% to about 6% w/w polysorbate 80, about 14% to about 16% w/w crospovidone, about 0.5 to about 2% w/w hydroxypropyl methylcellulose, about 5% to about 8% w/w sodium carbonate, and about 1 to about 2% w/w water; an initial seal coat comprising hydroxypropylmethyl cellulose on the spheroid core; and an enteric coat on the initial seal coat, wherein said multiparticulates have an average diameter of about 0.7 mm to about 1.25 mm.