Patent ID: 8500720
Filing Date: 2013-08-06
Classification: A61K,A61M

Abstract:
1. A method comprising: diagnosing a patient as having a cardiac disorder caused by a protein deficiency due to a gene mutation, the disorder being selected from the group consisting of glycogen storage disease Type II and Fabry disease; injecting a therapeutic protein formulation into an implantable source, the therapeutic protein formulation comprising a protein in a form that is deficient in cardiac cells in the patient with the cardiac disorder, the protein being selected from lysosomal acid α-glucosidase and α-galactosidase; determining a rate for delivering the therapeutic protein formulation based on the genetic sequence of the patient's gene encoding the deficient protein; and delivering the therapeutic protein formulation from the source through an implantable catheter directly to a pericardial sac region of a heart of a patient, wherein the source is an implantable pump that provides for a programmable delivery rate of the protein formulation, and wherein the protein formulation is delivered at the determined delivery rate.