Patent ID: 6479492
Filing Date: 2002-11-12
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of formula A: wherein:R7 is selected from the group consisting of hydrogen, hydroxy, chloro, and â€”NR30R31 wherein R30 is hydrogen, alkyl, substituted alkyl, or alkenyl; and R31 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, or â€”SO2R32 (wherein R32 is aryl or substituted aryl); or R30 and R31 together with the nitrogen atom to which they are attached form a heterocycle or substituted heterocycle; R8 is â€”NR33R34 wherein R33 is hydrogen, alkyl, substituted alkyl, or aryl; and R34 is alkyl, cycloalkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle substituted heterocycle, or â€”SO2R35 (wherein R35 is substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, or substituted heterocycle); or R33 and R34 together with the nitrogen atom to which they are attached form a heterocycle or substituted heterocycle; R11 and R11â€² are independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclic, substituted heterocyclic, and where R11 and R11â€² are joined to form a heterocycle or a substituted heterocycle; X is selected from the group consisting of hydroxyl, alkoxy, substituted alkoxy, alkenoxy, substituted alkenoxy, cycloalkoxy, substituted cycloalkoxy, cycloalkenoxy, substituted cycloalkenoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy and â€”NRâ€³Râ€³ where each Râ€³ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; and x is an integer from 1 to 4.