Patent ID: 6534276
Filing Date: 2003-03-18
Classification: A61K,A61P,C07K

Abstract:
A method of detecting a first polypeptide in a biological fluid, wherein said first polypeptide is selected from the group consisting of Tissue Factor Inhibitor (TFI) as shown in SEQ ID NO:2 and a polypeptide comprising one or more Kunitz domains of TFI, wherein the Kunitz domains consist of amino acids 47-117 of SEQ ID NO:2, amino acids 118-188 of SEQ ID NO:2, and amino acids 210-280 of SEQ ID NO:2, comprising the following steps;(a) containing said fluid with a second polypeptide having a binding specificity for said first polypeptide, and (b) assaying the presence of said second polypeptide to determine the level of said first polypeptide.