Patent ID: 6458823
Filing Date: 2002-10-01
Classification: C07D

Abstract:
A compound according to the formula wherein:R1 and R2 are independently straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbon atoms, or cycloalkyl of 3 to 6 carbon atoms where R1 and R2 may be optionally substituted by F, Cl, Br, I, OH, NH2, cyano, C1-C6 alkoxy, C1-C6 alkylthio, COOH or COOC1-C6 alkyl; R3 is a heteroaryl, optionally substituted with 1 to 4 groups selected independently from straight chain C1-C6 alkyl, branched alkyl of 3 to 6 carbons, or a cycloalkyl of 3 to 10 carbons; C1-C6 alkoxy, cyano, F, Cl, Br, C1-C6 alkylthio, CO2R1, CONH2, OH, NH2, and NO2; wherein heteroaryl is furan, thiophene, pyrrole, imidazole, oxazole, thiazole, isoxazole, pyrazole, isothiazole, oxadiazole, triazole, thiadiazole, and pyran; R4 is a straight chain alkyl group of 1 to 10 carbon atoms, a branched alkyl of 3 to 10 carbons, a cycloalkyl of 3 to 10 carbons, all of which may be optionally substituted by one or more F or Cl atoms; n is 0 or 1; all crystalline forms; an enantiomer or diastereomer, or a pharmaceutically acceptable salt thereof.