Patent ID: 6482957
Filing Date: 2002-11-19
Classification: C07D,C07F

Abstract:
A method for preparing a bicycloamide derivative represented by the formula (II): wherein R1 is an electron withdrawing group having sulfur atom or phosphorus atom directly bonded to the nitrogen atom of the amido group, comprising the step of:reacting in the presence of an organolithium compound and at a temperature of from âˆ’120Â° C. to 0Â° C., azabicyclo[2.2.1]hept-5-en-3-one represented by the formula (IV): â€ƒwith a compound represented by the formula (V): R1â€”Xâ€ƒâ€ƒ(V) â€ƒwherein R1 is an electron withdrawing group having sulfur atom or phosphorus atom directly bonded to X, and X is a halogen atom.