Patent ID: 6495567
Filing Date: 2002-12-17
Classification: A61K,A61P,Y10S

Abstract:
A method for treating diarrhea, comprising, administering an effective amount for inhibiting Clâˆ’ secretion of an aromatic compound to a subject, wherein the aromatic compound has the general formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein:n is 0, 1, 2, 3 or 4; p is 0 or 1; X is absent, (C1-C3)alkyl, (C1-C3)alkenyl, (C1-C3)alkynyl, SCH2, OCH2, or NOCH2; Y is C, N, P, Si or Ge; Râ€² is -halo, â€”R, â€”OR, â€”SR, â€”NR2, â€”ONR2, â€”NO2, â€”CN, â€”C(O)R, â€”C(S)R, â€”C(O)OR, â€”C(S)OR, â€”C(O)SR, â€”C(S)SR, â€”C(O)NR2, â€”C(S)NR2, â€”C(O)NR(OR), â€”C(S)NR(OR), â€”C(O)NR(SR), C(S)NR(SR), â€”CH(CN)2, â€”CH[C(O)R]2, â€”CH[C(S)R]2, â€”CH[C(O)OR]2, â€”CH[C(S)OR]2, â€”CH[C(O)SR]2, â€”CH aryl, or heteroaryl; Ar1 is aryl, substituted aryl, heteroaryl, (C5-C8)cycloalkyl or (C5-C8)heterocycloalkyl; Ar2 is aryl or substituted aryl; Ar3 is aryl, substituted aryl, biaryl, biphenyl, bibenzyl, or heteroaryl other than imidazole, nitroimidazole and triazole; each R is independently selected from the group consisting of â€”H, (C1-C6)alkyl, substituted (C1-C6)alkyl, (C1-C6)alkenyl, substituted (C1-C6)alkenyl(C1-C6)alkynyl, substituted (C1-C6)alkynyl, and (C1-C6)alkoxy; the aryl substituents are each independently selected from the group consisting of -halo, trihalomethyl, â€”R, â€”R1, â€”OR1, â€”SR1, NR12, â€”NO2, â€”CN, â€”C(O)R1, â€”C(S)R1, â€”C(O)OR1, â€”C(S)OR1, â€”C(O)SR, and â€”C(S)SR1; the alkyl, alkenyl and alkynyl substituents are each independently selected from the group consisting of -halo, â€”R1, â€”OR1, â€”SR1, N(R1)2, â€”NO2, â€”CN, â€”C(O)R12, â€”C(S)R1, â€”C(O)OR1, â€”C(S)OR1, â€”C(O)SR1, â€”C(S)SR1, aryl, &ggr;-butyrolactonyl, pyrrolidinyl and succinic anhydridyl; and each R1 is independently selected from the group consisting of â€”H, (C1-C6)alkyl, (C1-C6)alkenyl and (C1-C6)alkynyl, and provided that neither Ar1 nor Ar3 are oxadiazolyl when X is absent, Y is C, p=O, n=1-4, and Râ€²=NR2.