Patent ID: 6790938
Filing Date: 2004-09-14
Classification: A61K,A61P,C07K

Abstract:
An isolated human antibody or antigen binding fragment thereof which is able to bind to a GPIIb/IIIa complex, wherein the heavy chain of said antibody or antigen binding fragment comprises a CDR3 region a CDR2 region and a CDR1 region, wherein said CDR3 region is encoded by a nucleotide sequence selected from the group consisting of:(a) a nucleotide sequence which encodes the amino acid sequence: VLPFDPISMDV (SEQ ID NO:31), and (b) a nucleotide sequence which encodes the amino acid sequence ALGSWGGWDHYMDV (SEQ ID NO:32), and said CDR1 region is encoded by a nucleotide sequence selected from the group consisting of:(c) a nucleotide sequence which encodes the amino acid sequence: GYSWR (SEQ ID NO: 33), and (d) a nucleotide sequence which encodes the amino acid sequence: SYAMH (SEQ ID NO: 34), and said CDR2 region is encoded by a nucleotide sequence selected from the group consisting of:(e) a nucleotide sequence which encodes the amino acid sequence: DISYSGSTKYKPSLRS (SEQ ID NO: 35), and (f) a nucleotide sequence which encodes the amino acid sequence: VISYDGSNKYYADSVKG (SEQ ID NO: 36).