Patent ID: 6468991
Filing Date: 2002-10-22
Classification: A61K,A61P

Abstract:
A method of combatting a rhinoviral infection in a subject in need of such treatment, comprising administering to said subject a compound ofFormula I: wherein n is 0, 1, 2, or 3; each R1 and R2 is independently selected from the group consisting of hydrogen, halogen, and N3; each R5 is independently hydrogen or â€”OH; each R6 is independently hydrogen or â€”OH; R7 is Oâˆ’ or â€”OH; R9 is hydrogen or â€”OH, with the proviso that when R9 is â€”OH, R5 is hydrogen; Y is wherein m is 1, 2, or 3; X is â€”CHOHCH2OH, or is selected from the group consisting of wherein R3 and R4 are each independently selected from the group consisting of hydrogen, â€”OH, and â€”PO4âˆ’2, or R3 and R4 together represent a cyclophosphate; and A is selected from the group consisting of: wherein each R1 and R2 are as provided above; and R8 is selected from the group consisting of hydrogen, cyanogen, and amido; each Z is independently O or S; and each Zâ€² is independently O or S; or a pharmaceutically acceptable salt thereof;said compound being administered in an amount effective to combat the rhinoviral infection.