Patent ID: 6693126
Filing Date: 2004-02-17
Classification: A61K

Abstract:
A pharmaceutical composition for the hepatoprotection and treatment of liver diseases comprising as an active ingredient a dihydroxyphenyl derivative represented by the following formula (1), pharmaceutically acceptable acid addition salt or stereochemical isomer thereof together with a pharmaceutically acceptable inert carrier: in whichA and B both represent hydrogen, or together represent a methylene group, D represents hydrogen or C1-C4-alkoxy, E represents the following substituent (a-1) whereinR1 represents hydrogen, C1-C4-alkyl or N-acetylmethylaminomethyl, R2 represents hydrogen, or represents C1-C4-alkyl which is optionally substituted by hydroxycarbonyl, phenyl or 5- or 6-membered heteroaryl containing one or more hetero atoms selected from a group consisting of nitrogen and sulfur, wherein the heteroaryl can be substituted by C1-C4-alkyl, provided that when A and B together form a methylene group, D is hydrogen, R1 is hydrogen, and R2 is not hydroxycarbonylethyl; and provided that when A, B, D and R1 independently are hydrogen, R2 is not hydrogen.