Patent ID: 7456293
Filing Date: 2008-11-25
Classification: A61P,C07D

Abstract:
1. A compound represented by structural Formula 1: wherein R 1 , R 2 , R 3 and R 4 are independently selected from hydrogen, hydroxy, halogen, nitro, C 1-7 alkyl, —OC 1-7 alkyl, C 1-7 haloalkyl, —OC 1-7 haloalkyl, —SO 2 C 1-7 alkyl, —SO 2 NR a R b , —SO 2 phenyl, —OSO 2 C 1-7 alkyl, —C(O)C 1-7 alkyl, —COphenyl and phenyl, wherein the phenyl groups are unsubstituted or substituted with 1-3 substituents independently selected from halogen, —C 1-7 alkyl, —C 1-7 haloalkyl, —OC 1-7 alkyl, and —OC 1-7 haloalkyl; or adjoining pairs of R 1-4 , together with that portion of the ring to which they are attached, form a partially saturated or unsaturated 5-8 member cyclic ring containing from 0-4 heteroatoms independently selected from N, O and S, said ring is unsubstituted or independently substituted with 1-3 halogens and 1-4 C 1-7 alkyl groups; R R R R Ar is a 6-10 membered monocyclic or bicyclic ring system divalent linking group that is unsubstituted or substituted with 1-5 substituents independently selected from halogen, C X is a divalent linking group selected from ═O, ═CR n is an integer from 1-6; W is selected from the group of consisting of hydroxy, —OR each of R each of R R the asterisk represents an asymmetric carbon atom; each alkyl group is either linear or branched-chain; enriched enantiomers thereof and pharmaceutically acceptable salts thereof.