Patent ID: 9005904
Filing Date: 2015-04-14
Classification: A61P,C07K,G01N

Abstract:
1. An antibody that is immunospecific for an immunogenic region including an oxidized amino acid of an oxidized apoA-1 or an oxidized peptide fragment of apoA-I, or both, wherein the oxidized apoA-1 and oxidized apoA-1 comprising the oxidized apoA-1 fragment have reduced ABCA1-dependent cholesterol efflux activity or reduced lipid binding activity, or both, as compared to un-oxidized apoA-1, wherein said oxidized amino acid is selected from: chlorotyrosine, nitrotyrosine, trihydroxyphenylalanine, dihydroxyphenylalanine, and tyrosine peroxide, and wherein the oxidized amino acid is at position 18, 29, 166, 192 or 236 of SEQ ID NO: 1.