Patent ID: 9018379
Filing Date: 2015-04-28
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of preparing solifenacin or a salt thereof, comprising the steps of: (a) reacting (R)-quinuclidinol of Formula (VI): with bis(pentafluorophenyl)carbonate of Formula (VII): in an organic solvent to prepare (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate of Formula (IV): (b) reacting the (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate of Formula (IV): with (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline of Formula (V): in an organic solvent to prepare solifenacin of Formula (II):