Patent ID: 6242450
Filing Date: 2001-06-05
Classification: A61P,C07D

Abstract:
A substituted piperidine of Formula I: ##STR11##where:R and R' are independently hydrogen or hydroxy;AR.sup.1 is phenyl, naphthyl, quinolinyl, isoquinolinyl, indanyl, 1,2,3,4-tetrahydronaphthyl, indolyl, N-(C.sub.1 -C.sub.4 alkyl)indolyl, benzothiazolyl, benzothienyl, benzofuryl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzofuryl, julolidinyl, or dibenzofuryl, each optionally substituted with one or two substituents independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, benzoyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkylthio, trifluoromethyl, trifluoromethoxy, or halo;AR.sup.2 is pyridin-3-yl, quinolin-3-yl, isoquinolin-4-yl, or quinoxalin-2-yl; or pharmaceutically acceptable acid addition salts thereof.