Patent ID: 6020311
Filing Date: 2000-02-01
Classification: A61K,C07K

Abstract:
A hydrophobic GRF analog of formula A:X--GRF-peptide (A)wherein;the GRF peptide is a peptide of formula B:A1-A2-Asp-Ala-Ile-Phe-Thr-A8-Ser-Tyr-Arg-Lys-A13-Leu-A15-Gln-Leu-A18-Ala-Ar g-Lys-Leu-Leu-A24-A25-Ile-A27-A28-Arg-A30-R.sub.0 (B)wherein,A1 is Tyr or His;A2 is Val or Ala;A8 is Asn or Ser;A13 is Val or Ile;A15 is Ala or Gly;A18 is Ser or Tyr;A24 is Gln or His;A25 is Asp or Glu;A27 is Met, Ile or Nle;A28 is Ser or Asn;A30 is a bond or any amino acid sequence of 1 up to 15 residues;R.sub.0 is NH.sub.2 or NH--(CH.sub.2)n--CONH.sub.2, with n=1 to 12 and;X is hydrophobic tail anchored via an amide bond at the N-terminus of said peptide, and said hydrophobic tail defining a backbone of 5 to 7 atoms;wherein said backbone can be substituted by C.sub.1-6 alkyl, C.sub.1-6 cycloalkyl, or C.sub.6-12 aryl;and comprises at least one rigidifying moiety connected to at least two atoms of the backbone;said rigidifying moiety selected from the group consisting of double bond, triple bond, saturated or unsaturated C.sub.3-9 cycloalkyl, and C.sub.6-12 aryl.