Patent ID: 7067260
Filing Date: 2006-06-27
Classification: A61K,C07K,G01N

Abstract:
1. A method for identifying a binding analog for a morphogen receptor, said morphogen sharing at least 60% amino acid sequence identity or at least 70% amino acid sequence homology with the sequence of the C-terminal 102 amino acid of SEQ ID NO: 7, and being able to substitute for OP-1 in binding to a protein comprising SEQ ID NOs. 4, 6, or 8, said binding analog having substantially the same binding affinity for said morphogen receptor as said morphogen, the method comprising: (a) providing a sample without a Type II serine/threonine kinase morphogen receptor but containing a protein selected from: (b) contacting said sample with a candidate morphogen receptor-binding analog; and (c) detecting specific binding between said candidate morphogen receptor-binding analog and said protein; wherein binding of said candidate morphogen receptor-binding analog to said protein is indicative that said candidate analog is a morphogen receptor-binding analog.