Patent ID: 6750212
Filing Date: 2004-06-15
Classification: A61K,A61P

Abstract:
A method for the treatment of disorders or abnormalities of internal surfaces of the body which are responsive to photochemotherapy, said method comprising simultaneous, separate or sequential administration to affected surfaces of the body of a protoporphyrin precursor photochemotherapeutic agent and a vascular stroma-localizing photosensitizer, and optionally at least one chelating agent, wherein the photochemotherapeutic agent and photosensitizer have a syncrgistically enhanced therapeutic efficacy relative to the photochemotherapeutic agent or photosensitizer alone, and wherein the total dosage of the vascular stroma-localizing photosensitizer administered is in the range of 0.01 to 10 mg/kg body weight and the total dosage of the protoporphyrin precursor photochemotherapeutic agent administered is in the range of 1 to 500 mg/kg body weight, and exposing the surfaces to light.