Patent ID: 6500864
Filing Date: 2002-12-31
Classification: A61P,C07C,Y10S

Abstract:
A topically or locally administrable pharmaceutical composition for treating allergic diseases of the eye, nose, skin, ear or lung comprising a tonicity-adjusting agent in an amount sufficient to cause the composition to have an osmolality of 150-450 mOsm, a pharmaceutically acceptable preservative and a disulfide derivative of the formula whereinX=â€”NHC(&boxH;O)NHâ€”R; R=H; (un)substituted phenyl; (un)substituted benzyl; or C1-C8 alkyl or alkenyl, optionally substituted with or terminated by OH, OR2, NR3R4; C4-C7 cycloalkyl, (un)substituted aryl, or (un)substituted 5-7 membered heterocyclic ring; where optional substituents are selected from the group consisting of C1-C6 alkyl or alkoxy; halogen; OH; CN; CF3; NO2; and CO2R2; R2=C1-C3 alkyl; and R3 and R4 are independently H; benzyl; C1-C8 alkyl or alkenyl; C4-C7 cycloalkyl; (un)substituted aryl; or (un)substituted 5-7 membered heterocyclic ring; wherein optional substituents are selected from the group consisting of C1-C6 alkyl or alkoxy; halogen; OH; CN; CF3; NO2; and CO2R2.