Patent ID: 8673584
Filing Date: 2014-03-18
Classification: A61P,C07C,C07D,G01N

Abstract:
1. A composition comprising an oxalate and phosphoenolpyruvate binding pocket of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in crystalline form, wherein said oxalate and phosphoenolpyruvate binding pocket comprises R87, Y235, G237, K244, S286, F333, N403 and R405 of PEPCK, and wherein the crystalline form comprises crystals that belong to space group P2 1 with a combination of unit cell parameters selected from the group of a=64.0 Å, b=118.9 Å, c=86.5 Å, α=γ=90° and β=107°, a=62.3 Å, b=119.5 Å, c=86.9 Å, α=γ=90° and β=107.1°, a=60.7 Å, b=119.7 Å, c=90.9 Å, α=γ=90° and β=108.9°, a=45.3 Å, b=119.4 Å, c=60.8 Å, α=γ=90° and β=108.7°, and a=45.2 Å, b=119.0 Å, c=60.9 Å, α=γ=90° and β=108.8°.