Patent ID: 6593296
Filing Date: 2003-07-15
Classification: A61K,A61P

Abstract:
A method for the preparation of a stable, liquid formulation of growth hormone, comprising growth hormone, a buffer and at least one stabilizer selected from the group consisting of:(i) polyoxyethylene-polyoxypropylene block copolymer non-ionic surfactants, (ii) taurocholic acid or salts or derivatives thereof, and (iii) methyl cellulose derivatives, wherein the method comprises the step of adding said buffer and stabilizer(s) to a solution of growth hormone such that the growth hormone is not exposed to concentrations of said buffer or stabilizer(s) that are greater than two times the final concentrations of said buffer or stabilizer(s) in the formulation, such that the formulation is suitable for prolonged storage at temperatures below and above freezing.