Patent ID: 7745427
Filing Date: 2010-06-29
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: wherein: Z is selected from: A is C(R B is (C(R D is selected from R R R R R W is O, NR X is C or S; Y is O, (R R J is a bond, C(R V is selected from a bond, C(R G-L is selected from: N, N—C(R Q is selected from: T is selected from: R R “heteroaryl” is a 5- to 7-membered monocyclic- or 9- to 10-membered fused bicyclic heterocyclic ring system which contains an aromatic ring, any ring of which may be saturated partially saturated, or unsaturated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O and S, and wherein the N and S heteroatoms may optionally be oxidized, and the N may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring; “heterocyclic” is a 5- to 7-membered monocyclic- or 8- to 11-membered bicyclic heterocyclic ring system which is either saturated or unsaturatated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O and S, and wherein the N and S heteroatoms may optionally be oxidized, and the N heteroatom may be optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring; p is 0 to 2q+1, for a substituent with q carbons; m is 0,1 or 2; n is 1; s is 1,2 or 3; or a pharmaceutically acceptable salt or individual diastereomers thereof.