Patent ID: 9029391
Filing Date: 2015-05-12
Classification: A61K,C07D

Abstract:
1. A compound comprising the structure of Formula (II): or a pharmaceutically acceptable salt thereof, wherein: L is linker that is selected from the group consisting of a direct bond, methylene, —SO2—, and —C(O)NH—; X is phenyl; R4 is selected from the group consisting of phenyl, dihydrobenzopyranyl, naphthalenyl, pyridinyl, benzodioxolyl, benzodioxinyl, dihydrobenzodioxepinyl, quinolinyl, dihydrobenzofuranyl, tetrahydroisoquinolinyl, dihydrobenzoxazinyl, dihydroindenyl, benzothiazolyl, furanyl, pyrazolyl, and tetrahydropyridoquinolinyl; R5, R6, and R7 are independently selected from H, methyl, ethyl, propyl, butyl, hydroxyl, fluoro, chloro, bromo, methoxy, ethoxy, propoxy, methoxyethoxy, fluorophenylmethoxy, difluorophenylmethoxy, pyridinylmethoxy, trifluorophenylmethoxy, fluoropyridinylmethoxy, methylpyridinylmethoxy, phenyl, dimethyloxazolylmethoxy, thiophenylmethoxy, fluoroethoxy, chlorothiophenylmethoxy, methylthiophenylmethoxy, hydroxyethoxy, dimethylaminoethoxy, difluoromethoxy, pyrrolidinylethoxy, morpholinylethoxy, carboxylmethoxy, dimethylsulfamoyloxy, trifluoromethyl, methylsulfonylphenylmethoxy, chlorophenylmethoxy, pyrimidinylmethoxy, trifluoromethoxyphenylmethoxy, chlorobromophenylamino, piperidinyl, piperidinylmethyl, dioxothiomorpholinyl, morpholinyl, morpholinylcarbonyl, ethylamide, fluorophenyl, methoxyphenylmethyl, methylpyridinyl, phenylmethyl, phenylethyl, nitrile, aminocarbonyl, aminomethyl, morpholinylmethyl, bis(pyridinylmethyl)aminomethyl, pentylpyrazolyl, pyridinylmethylaminomethyl, acetamidomethyl, ethylureidomethyl, pyridinyl, carboxyformamidomethyl, methylsulfonamidomethyl, dimethylaminophenyl, dimethylaminosulfonylaminomethyl, methylpyrrolyl, methylpyrazolyl, methylfuranyl, furanyl, dimethylpyrazolyl, pyrazolyl, methoxypyridinyl, and dimethylisoxazolyl; R9 is independently selected from the group consisting of —H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, and septyl; R10 is selected from the group consisting of —H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, penty, and septyl; R11, R12, and R13 are independently selected from the group consisting of —H, methyl, ethyl, methoxy, ethoxy, oxo, chloro, fluoro, bromo, trifluoromethyl, trifluoromethoxy, methylsulfonyl, —C(O)methyl, —C(O)R15, and methylmethoxy; R14 is selected from the group consisting of chloro, fluoro, and bromo; R15 is —N(R16)2; R16 is independently selected from the group consisting of —H, methyl, ethyl, hydroxyl, methylsulfonyl, —SO2N(methyl)2, —C(O)NHmethyl, —C(O)R18, and —(X)(R11); R17 is —OR9; and R18 is —CO2R9.