Patent ID: 6310092
Filing Date: 2001-10-30
Classification: A61P,C07D

Abstract:
A method for preventing the onset of an autoimmune or inflammatory disease in a patient at risk for developing an autoimmune or inflammatory disease which method comprises:(a) identifying a patient at risk for developing an autoimmune or inflammatory disease;(b) administering to said patient a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective autoimmune or inflammatory disease-preventing amount of a compound of formula I: ##STR10##whereinR.sup.1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cyloalkyl, cycloalkylalkyl and cycloalkenyl;each R.sup.2 is independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, alkoxy, substituted alkoxy, cycloalkyl and halo;R.sup.3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl and cycloalkylalkyl;R.sup.4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl; andn is an integer ranging from 0 to 2; and optical isomers and racemates thereof, and pharmaceutically acceptable salts thereof.