Patent ID: 6211228
Filing Date: 2001-04-03
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula:[Z--X.sup.1 --X.sup.2 --X.sup.3 --X.sup.4 --X.sup.5 ].sub.2 Yin which:Z is amino, guanidino or amidino;Y is optionally substituted heterocyclo(C.sub.3-14)alkylene containing one or more oxygen atoms;X.sup.1 is optionally substituted (C.sub.3-6)alkylene, optionally substituted oxa(C.sub.4-6) alkylene or --X.sup.6 --X.sup.7 --X.sup.8 -- (wherein X.sup.7 is optionally substituted phenylene, optionally substituted cyclo(C.sub.3-6)alkylene or optionally substituted heterocyclo(C.sub.3-6)alkylene and X.sup.6 and X.sup.8 are optionally substituted (C.sub.n6)alkylene and optionally substituted heterocyclo(C.sub.n8)alkylene, respectively, wherein the sum of n6 and n8 is equal to 1, 2, 3 or 4, with the proviso that when Z is amino n6 is not 0);X.sup.2 and X.sup.4 are independently --C(O)--, --C(O)O--, --OC(O)--, --C(O)N(R.sup.1)--, --N(R.sup.1)C(O)--, --OC(O)NR.sup.1)--, --N(R.sup.1)C(O)O--, --N(R.sup.1)C(O)N(R.sup.1)-- or --OC(O)O-- (wherein each R.sup.1 is independently hydrogen, optionally substituted (C.sub.1-8)alkyl or optionally substituted cyclo(C.sub.3-8) alkyl);X.sup.3 is optionally substituted (C.sub.1-8)alkylene, --X.sup.9 --X.sup.10 -- or --X.sup.10 --X.sup.9 -- (wherein X.sup.9 is optionally substituted (C.sub.n9)alkylene, wherein n9 is 0, 1 or 2, and X.sup.10 is optionally substituted cyclo(C.sub.3-8)alkylene or optionally substituted heterocyclo(C.sub.3-8)alkylene, with the proviso that covalent bonds do not occur between hetero atoms contained within X.sup.10 and hetero atoms contained within either X.sup.2 or X.sup.4); andX.sup.5 is optionally substituted (C.sub.n5)alkylene wherein n5 is 0, 1 or 2; and the pharmaceutically acceptable salts thereof.