Patent ID: 7569559
Filing Date: 2009-08-04
Classification: A61K

Abstract:
1. A composition comprising a C-based diazeniumdiolate compound, wherein said composition releases NO under physiological conditions in predictable and tunable quantities and does not generate nitrosamines under physiologic conditions, wherein said C-based diazeniumdiolate compound is represented by the formula: wherein x is an integer from 0 to 2 and y is an integer from 1 to 3 and the sum of x plus y equals 3; wherein R wherein R wherein said protecting group is selected from the group consisting of aryl, glycosyl, acyl, alkyl and olefinic groups; wherein said alkyl group is selected from the group consisting of saturated alkyl, unsaturated alkyl, and functionalized alkyl; and wherein said functionalized alkyl is selected from the group consisting of 2-bromoethyl, 2-hydroxypropyl, 2-hydroxyethyl and S-acetyl-2-mercaptoethyl;