Patent ID: 7939052
Filing Date: 2011-05-10
Classification: A61B,A61K

Abstract:
1. A method of screening a candidate compound for an ability to increase the biological activity of an urotensin II receptor in an animal, comprising the steps of: a. administering the candidate compound to the animal; b. measuring the redness or the skin temperature of an ear of the animal within an effective time period; c. comparing said redness or skin temperature to a baseline redness or skin temperature of the ear or to the redness or skin temperature of the ear prior to administering said candidate compound; d. correlating an increase in the redness or the skin temperature of the ear of the animal with the ability of the candidate compound to increase the biological activity of the urotensin II receptor in the animal; and e. further testing the candidate compound in an assay for the urotensin II receptor if the administration of the candidate compound results in an increase in the redness of the skin temperature of the ear of the animal.