Patent ID: 6448277
Filing Date: 2002-09-10
Classification: A61K,A61P,C07D

Abstract:
A method of treating a warm-blooded animal with a neoplastic disease that responds to an inhibitor of VEGF receptor tyrosine kinase, which comprises administering to the warm-blooded animal an effective amount of a compound of formula I, whereinW is O or S X is NR8; Y is CR9R10â€”(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R1 is aryl; R2 is a 5- or 6-member heteroaryl ring comprising one ring nitrogen; any of R3, R4, R5 and R6, independently of the other, is H, halogen, lower alkyl or two adjacent substituents together are lower alkylene dioxy; and R7 and R8, independently of each other, are H or lower alkyl; or an N-oxide or a pharmaceutically acceptable salt thereof.