Patent ID: 7767693
Filing Date: 2010-08-03
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of inhibiting a heat shock protein 90 (Hsp90) family protein, comprising administering an effective amount of a benzoyl compound represented by formula (IA): wherein nA represents an integer of 1 to 5; R R R R wherein (i) substituents in the substituted lower alkyl, the substituted lower alkoxy and the substituted lower alkoxycarbonyl are 1 to 3 substituents independently selected from the group (A) consisting of hydroxy, oxo, cyano, nitro, carboxy, amino, halogen, substituted or unsubstituted lower alkoxy, cycloalkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylamino and di-lower alkylamino, wherein substituents in said substituted lower alkoxy are 1 to 3 substituents independently selected from the group consisting of hydroxy and halogen, and (ii) substituents in the substituted cycloalkyl, the substituted heterocyclic alkyl, the substituted aryl, the substituted lower alkanoyl, the substituted heterocyclic group, the substituted aralkyl, the substituted aroyl and the substituted heterocyclic group formed together with the adjacent nitrogen atom are 1 to 3 substituents independently selected from the group (B) consisting of hydroxy, halogen, nitro, cyano, amino, carboxy, carbamoyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, aralkyloxy, lower alkylsulfonyl, lower alkylsulfanyl, cycloalkyl, lower alkoxycarbonyl, lower alkylamino, di-lower alkylamino, lower alkanoyl, a heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic alkyloxy and substituted or unsubstituted heterocyclic carbonylalkyloxy, wherein substituents in said substituted lower alkyl, said substituted lower alkoxy and said substituted aryl are 1 to 3 substituents independently selected from the group consisting of hydroxy, halogen, lower alkoxy, cyano, lower alkylamino and di-lower alkylamino, and substituents in said substituted heterocyclic alkyloxy and said substituted heterocyclic carbonylalkyloxy are 1 to 3 substituents independently selected from the group consisting of hydroxy, halogen, lower alkyl, lower alkoxy and a heterocyclic group, or a pharmaceutically acceptable salt thereof.