Patent ID: 8202911
Filing Date: 2012-06-19
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating breast tumor metastasis in a subject comprising: administering to a subject in need thereof a therapeutically effective amount of a composition comprising a compound having one of the following structures: or pharmaceutically acceptable salt thereof; wherein R R the bond R or R 4A and R 4B are independently a C 1-16 alkyl group optionally substituted with one or more of C 1-20 aliphatic; C 3-14 aryl; C 3-14 heteroaryl; C 1-20 alkylC 3-14 aryl; C 1-20 alkylC 3-14 heteroaryl, C 3-14 aryloxy; C 1-20 heteroalkoxy, C 3-14 heteroaryloxy; C 1-20 alkylthio; C 3-14 arylthio; heteroC 1-20 alkylthio; heteroC 3-14 arylthio; F; Cl; Br; I; —OH; —NO 2 ; —CN; —CF 3 ; —CH 2 CF 3 ; —CHCl 2 ; —CH 2 OH; —CH 2 CH 2 OH; —CH 2 NH 2 ; —CH 2 SO 2 CH 3 ; —C(O)R x ; —CO 2 (R x ); —CON(R x ) 2 ; —OC(O)R x ; —OCO 1 R x ; —OCON(R x ) 2 ; —N(R x ) 2 ; S(O) 2 R x ; —NR x (CO)R x wherein each occurrence of R x is independently C 1-20 aliphatic, heteroC 1-20 aliphatic, C 3-14 aryl, C 3-14 heteroaryl, C 1-20 alkylC 3-14 aryl or C 1-20 alkylC 3-14 heteroaryl; X Q is hydrogen, halogen, —CN, —S(O) Y W is O or NH; and R wherein for the compound of formula (a), when X wherein the composition is administered at a dose corresponding to a dose in a mouse that is between about 10 mg/kg and about 20 mg/kg.