Patent ID: 6441007
Filing Date: 2002-08-27
Classification: A61K,A61P,C07D

Abstract:
A method for treating a central nervous system disorder comprising administering to a subject in need thereof, an effective amount of a compound of the formula: where X is selected from the group consisting of Câ€”H, Câ€”F, Câ€”Cl, Câ€”Br, Câ€”I, Câ€”Râ€², Câ€”NRâ€²Râ€³, Câ€”CF3, Câ€”OH, Câ€”CN, Câ€”NO2, Câ€”C2Râ€², Câ€”SH, Câ€”SCH3, Câ€”N3, Câ€”SO2CH3, Câ€”ORâ€², Câ€”SRâ€², Câ€”C(&boxH;O)NRâ€²Râ€³, Câ€”NRâ€²C(&boxH;O)Râ€², Câ€”C(&boxH;O)Râ€², Câ€”C(&boxH;O)ORâ€², C(CH2)qORâ€², Câ€”OC(&boxH;O)Râ€², COC(&boxH;O)NRâ€²Râ€³ and Câ€”NRâ€²C(&boxH;O)ORâ€² wherein Râ€² and Râ€³ are individually hydrogen, lower alkyl, an aromatic group containing species or a substituent aromatic group; and q is an integer from 1 to 6; Xâ€² is nitrogen; m is an integer and n is an integer such that the sum of m plus n is 1, 2, 3, 4, 5, 6, 7, or 8; E, Eâ€², Eâ€³ and Eâ€²â€³ individually are hydrogen or lower alkyl; Zâ€² and Zâ€³ individually are hydrogen or lower alkyl; Aâ€² and Aâ€³ are selected from the group consisting of H, C(CH2)qORâ€², Râ€², NRâ€²Râ€³, CF3, OH, CN, NO2, C2Râ€², SH, SCH3, N3, SO2CH3, ORâ€², SRâ€², C(&boxH;O)NRâ€²Râ€³, NRâ€²C(&boxH;O)Râ€², C(&boxH;O)Râ€², C(&boxH;O)ORâ€², OC(&boxH;O)NRâ€²Râ€³ and NRâ€²C(&boxH;O)ORâ€², F, Br, Cl and I; wherein Râ€², Râ€³ and q are as defined previously; and A is selected from the group consisting of hydrogen, lower alkyl, F, Br, Cl, and I.