Patent ID: 6794397
Filing Date: 2004-09-21
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula III: or a pharmaceutically acceptable salt or prodrug thereof, whereinR1 and R5 are independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, halogen, NO2, cyano, haloalkyl, haloalkoxy, amino and aminoalkyl, provided that at least one of R1 and R5 is selected from the group consisting of NO2, cyano, alkyl and haloalkyl; R2 and R4 are independently selected from the group consisting of hydrogen, hydroxy, halogen, cyano, haloalkyl, haloalkoxy, amino and aminoalkyl; R3 is propyl, isopropyl, butyl, sec-butyl, tert-butyl, 3-pentyl, hexyl, octyl, Cl, F, haloalkyl, alkoxy, arylalkoxy, cyano, haloalkyloxy, amino or aniinoalkyl; R6 is hydrogen, hydroxy, alkyl, NO2, cyano, haloalkyl, haloalkyloxy, amino or aminoalkyl; R7 is hydrogen, hydroxy, alkyl, NO2, cyano, haloalkyl, haloalkyloxy, amino or aminoalkyl; R9 is hydroxy, alkyl, halogen, NO2, haloalkyl, alkoxy, cyano, haloalkyloxy, amino or aminoalkyl; R10 is hydrogen, hydroxy, alkyl, Cl, F, NO2, cyano, haloalkyl, haloalkyloxy, amino or aminoalkyl; and R11 is hydrogen, alkyl or haloalkyl; wherein said prodrug is: a) an ester of a carboxylic acid containing compound of Formula III obtained by condensation with a C1-4 alcohol; b) an ester of a hydroxyl group containing compound of Formula III obtained by condensation with a C1-4 carboxylic acid, C3-6 dioic acid or anhydride thereof; c) an imine of an amine group containing compound of Formula III obtained by condensation with a C1-4 aldehyde or ketone; or d) an acetal or ketal of at least one of the R1-10 hydroxy containing groups obtained by condensation with chloromethyl methyl ether or chloromethyl ethyl ether.