Patent ID: 8449889
Filing Date: 2013-05-28
Classification: A61K,A61P,C07K

Abstract:
1. A method of selectively killing a tumor cell in a patient, the cell presenting an antigen, the method comprising administering to the patient a molecule which comprises consecutive amino acids present in the following consecutive segments, beginning at the amino terminus of the molecule: (i) a human MHC-restricted peptide capable of eliciting a memory response when present in the molecule, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a human MHC class I molecule, and (vi) an antibody targeting domain which comprises an association of a heavy chain variable region and a light chain variable region, wherein said antibody is specific to said antigen, wherein the consecutive amino acids which correspond to segments (v) and (vi) are linked to each other directly by a peptide bond or by a third peptide linker and wherein the carboxyl terminus of each of segments (i) through (v) is covalently linked to the amino terminus of segments (ii) through (vi), respectively, whereby said molecule initiates a CTL mediated immune response against said cell, thereby selectively killing the tumor cell.