Patent ID: 6326380
Filing Date: 2001-12-04
Classification: C07D

Abstract:
A compound represented by the structural formula ##STR2152##or a pharmaceutically acceptable salt thereof, wherein:the single dotted line represents an optional double bond;n is 0;Q is ##STR2153##whereinn.sub.1 and n.sub.2 are independently 0-2; or when the double bond is not present, Q is also fused R-substituted aryl;R is 1 to 3 substituents independently selected from the group consisting of H, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, and (C.sub.1 -C.sub.6)alkoxy;R.sup.1 and R.sup.2 are independently selected from the group consisting of H and C.sub.1 -C.sub.6 alkyl;R.sup.3 is H or C.sub.1 -C.sub.6 alkyl;Het is W-pyridyl or W-quinolyl, wherein Het is attached to B by a carbon atom ring member, and wherein the Het group is substituted by 1 to 4 substituents, W, independently selected from the group consisting of H; C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 alkoxy; R.sup.21 -aryl; aryl wherein adjacent carbons form a ring with a methylenedioxy group; heteroaryl; heteroaryl substituted by 1 to 4 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, (C.sub.1 -C.sub.6)alkyl-amino, di-((C.sub.1 -C.sub.6)alkyl)amino, --OCF.sub.3, --NO.sub.2, hydroxy(C.sub.1 -C.sub.6)alkyl, --CHO and phenyl; and heteroaryl wherein adjacent carbon atoms form a ring with a C.sub.3 -C.sub.5 alkylene group or a methylenedioxy group;R.sup.8, R.sup.10 and R.sup.11 are H, provided that when the optional double bond is present, R.sup.10 is absent, and when ring Q is aromatic, R.sup.10 and R.sup.11 are absent;R.sup.9 is H, OH, or C.sub.1 -C.sub.6 alkoxy;B is trans --CH.dbd.CH--;X --OH;Y.dbd.O, (H, H), (H, OH) or (H, C.sub.1 -C.sub.6 alkoxy);R.sup.15 is H or --NR.sup.18 R.sup.19 ;R.sup.16 is independently selected from the group consisting of C.sub.1 -C.sub.6 lower alkyl, phenyl or benzyl;R.sup.17 is independently selected from the group consisting of H, C.sub.1 -C.sub.6 alkyl, phenyl and benzyl;R.sup.18 and R.sup.19 are independently selected from the group consisting of H and C.sub.1 -C.sub.6 alkyl;R.sup.21 is 1 to 3 substutuents independently selected from the group consisting of --CF.sub.3, --OCF.sub.3, halogen, --NO.sub.2, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, (C.sub.1 -C.sub.6)alkylamino, di-((C.sub.1 -C.sub.6)alkyl)amino, amino(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)-alkylamino(C.sub.1 -C.sub.6)alkyl, di-((C.sub.1 -C.sub.6)alkyl)-amino(C.sub.1 -C.sub.6)alkyl, hydroxy-(C.sub.1 -C.sub.6)alkyl, --COOR.sup.17, --COR.sup.17, --NHCOR.sup.16, --NHSO.sub.2 R.sup.16 and --NHSO.sub.2 CH.sub.2 CF.sub.3 ; andZ is --CH.sub.2 --.