Patent ID: 6632919
Filing Date: 2003-10-14
Classification: C07K

Abstract:
A compound for binding Watson-Crick base pairs in a double helix having the formula: wherein:R8 is H, COCH3 or an amino protecting group; R9 is hydrogen or a side chain of a naturally occurring amino acid; R10 is O, NH, O-alkylene or a lysine residue; W is â€”(CH2)mâ€” where m is from 0 to 6, or whereb is an integer from 0 to 4; k is from 0 to 5; n is 0 or 1; L has the formula Q is CH or N; R17 is H or C1-C8 alkyl; each R11 and R12 is, independently, H, C1-C8 alkyl, or halogen; or R11 and R12 together with the carbon atoms to which they are attached form a phenyl group; T has the formula: j and z are each, independently, from 0 to 5 with the sum of j and z being from 1 to 7; M is C(&boxH;O), S(O)2, phenyl or P(O)2; V is NH, S, or CH2; a, h and g are each, independently, 0 or 1; and R13 and R14 are each independently H or a nitrogen or oxygen protecting group.