Patent ID: 9034334
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of measuring Aβ protofibrils in a mammal, said method comprising the steps of: (a) providing a labeled antibody or fragment thereof, being selective and having high affinity for human Aβ protofibrils, and wherein the labeled antibody or fragment thereof in its six CDR regions comprises: said antibody or fragment thereof is labeled with an agent that generates a measurable signal; (b) administering the labeled antibody or fragment thereof to a mammal comprising or suspected of comprising Aβ protofibrils; and (c) measuring the concentration of a complex formed between said Aβ protofibril and said antibody or fragment thereof by measuring the signal generated by the agent.