Patent ID: 9085630
Filing Date: 2015-07-21
Classification: A61K,A61N,A61P,C07K

Abstract:
1. A method of inhibiting the growth of a cell that expresses a protein having: (a) the amino acid sequence—shown in (b) an extracellular domain of the polypeptide having the amino acid sequence shown in (c) a polypeptide encoded by the nucleotide sequence shown in (d) a polypeptide encoded by the full-length coding region of the nucleotide sequence shown in said method comprising contacting said cell with an antibody that binds to said protein, wherein said antibody is conjugated to a growth inhibitory agent or cytotoxic agent and is internalized by and inhibits the growth of a cell expressing said polypeptide, wherein said cell is a cancer cell selected from the group consisting of a leukemia cell, a lymphoma cell and a myeloma cell.