Patent ID: 6262303
Filing Date: 2001-07-17
Classification: C07C

Abstract:
A process for the preparation of S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)ami no]-2,4,6-triiodo-1,3-benzenedicarboxamide, said process comprising forming S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-acetyloxy-1-oxopropyl)a mino]-2,4,6-triiodo-1,3-benzenedicarboxamide from S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]-amino]-2,4,6-triiodo-1,3-benzendicarb oxylic acid di-chloride and 2-amino-1,3-propanediol in a solvent selected from the group consisting of a lower alcohol or monoalkyl ether glycol.