Patent ID: 8227503
Filing Date: 2012-07-24
Classification: A61P,C07D

Abstract:
1. A method for treating, alleviating or diagnosing a neoplastic disease comprising administering to a subject a therapeutically effective amount of a compound having the structure of Formula (I), or pharmaceutically acceptable salt, ester or prodrug thereof, wherein Formula (I) has the structure: wherein: R R R n is 1, 2 or 3; E E E E provided that when R R 4 has a molecular weight equal to or greater than 92 g/mol; and provided that when R R 4 has a molecular weight equal to or greater than 77 g/mol; wherein the neoplastic disease is a cancer is selected from the group consisting of: breast cancer, sarcoma, leukemia, ovarian cancer, bladder cancer, prostate cancer, colon cancer, rectal cancer, stomach cancer, lung cancer, lymphoma, multiple myeloma, pancreatic cancer, kidney cancer, endocrine cancer, melanoma, skin cancer, angiosarcoma, sinus cancer, esophageal cancer, uretal cancer, liver cancer, angioma, central nervous system (CNS) cancer, Mantle cell lymphoma, low IgM secreting lymphoma, Burkitt's lymphoma, B-NHL and Waldenstrom's Macroglobulinemia.