Patent ID: 8952130
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. A recombinant TGF-β ligand polypeptide having at least 95% sequence identity to an amino acid sequence comprising a first segment of amino acid residues comprising amino acid residues 1 to 32 of SEQ ID NO:2 (“1b”); a second segment of amino acid residues comprising amino acid residues 30 to 45 of SEQ ID NO:5 (“2a”); a third segment of amino acid residues comprising amino acid residues 46 to x wherein: a fourth segment of amino acid residues comprising amino acid residues x wherein: a fifth segment of amino acid residues comprising amino acid residues x wherein: a sixth segment comprising amino acid residues x wherein: wherein the recombinant TGF-β ligand polypeptide activates cell proliferation or activity associated with SMAD pathway.