Patent ID: 8609635
Filing Date: 2013-12-17
Classification: A61P,C07F

Abstract:
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: A is -alkylene-N(R B is 5-membered monocyclic heteroarylene group or a 9-membered bicyclic heteroarylene group containing at least one nitrogen atom, wherein said 5-membered monocyclic heteroarylene group and said 9-membered bicyclic heteroarylene group can be optionally fused to a benzene, pyridine or pyrimidine ring, and wherein said 5-membered monocyclic heteroarylene group or its fused counterpart and said 9-membered bicyclic heteroarylene group or its fused counterpart, can be optionally and independently substituted on one or more ring nitrogen atoms with R C is a bond, —C(R D is -alkylene-N(R M X X each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R and wherein an R 15 group can be optionally and independently substituted on one or two ring carbon atoms with R 12 ; each occurrence of R and wherein when R 16 is said 3 to 7-membered cycloalkyl group, said 4- to 7-membered heterocycloalkyl group, said phenyl group or said heteroaryl group, then R 16 can be optionally substituted with up to three groups, which can be the same or different, and are selected from C 1 -C 6 alkyl, halo, —C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, —OH, —C(O)NH—(C 1 -C 6 alkyl), —C(O)N(C 1 -C 6 alkyl) 2 , —O—(C 1 -C 6 alkyl), —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 and —NHC(O)—(C 1 -C 6 alkyl); each occurrence of R and wherein an R 17 group can be optionally and independently substituted on one or two ring carbon atoms with up to two R 12 groups; each occurrence of q is independently an integer ranging from 1 to 4; and each occurrence of r is independently an integer ranging from 0 to 6, wherein at least one of A and D is R