Patent ID: 8716455
Filing Date: 2014-05-06
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A pharmaceutical composition comprising an antibody conjugated to a therapeutic agent and a pharmaceutically compatible carrier or adjuvant, wherein the antibody is capable of specifically binding to an extracellularly exposed region of a protein or polypeptide, said protein or polypeptide being encoded by a nucleic acid which is selected from the group consisting essentially of: (a) a nucleic acid which comprises a nucleic acid sequence set forth in SEQ ID NO. 19; and (b) a nucleic acid which hybridizes with the complement to the nucleic acid of (a) under stringent conditions, wherein the stringent conditions are a hybridization temperature of 65° C. in a hybridization buffer containing 3.5×SSC, 0.02% Ficoll, 0.02% polyvinylpyrrolidone, 0.02% bovine serum albumin, 2.5 mM NaH