Patent ID: 6500948
Filing Date: 2002-12-31
Classification: C07D

Abstract:
A compound of formula 8: whereinD is N, Z is O or S, R1 and R2 are each a methyl group, and Q is a cycloalkyl group, an aryl group, a heteroaryl group, a heterocycloalkyl group, or a group of formula â€ƒwherein A is C or Si and R8, R9, and R10 are independently selected from H and any suitable organic moiety selected from the group consisting of oxo, hydroxy, halo, cyano, nitro, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and trialkylsilyl groups, and moieties of formulae (A), (B), (C), (D), (E), (F), (G), (H), (J), and (K): (A) â€”C(O)â€”Ra, wherein Ra is hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, (B) â€”C(O)â€”Oâ€”Ra, wherein Ra is hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, (C) â€”C(O)â€”NRcRb, wherein Rb and Rc are independently hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, (D) â€”C(&boxH;NRd)Re, wherein Rd is hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, or acylamino group, and Re is hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, alkylamino, or dialkylamino group, (E) â€”S(O)2â€”Rf, wherein Rf is an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, (F) â€”S(O)2â€”NRgRh, wherein Rg and Rh are independently hydrogen or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, (G) â€”Oâ€”Ri, wherein Ri is an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, or a moiety of formula (A), (B), (C), (H), or (K), (H) â€”NRjRk, wherein Rj is hydrogen, or an alkyl, cycloalkyl heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, amino group, or a moiety of formula (A), (B), (C), or (D), and Rk is hydrogen, or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, or a moiety of formula (A), (B), (C), (D), (E), or (F), (J) â€”Sâ€”Rl, wherein Rl is hydrogen, or an alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, or a moiety of formula (C), and (K) â€”P(O)RmRn, wherein Rm and Rn are independently an alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, amino, alkylamino, or dialkyl amino group, or a salt or solvate thereof.