Patent ID: 6313313
Filing Date: 2001-11-06
Classification: A61K,A61Q

Abstract:
A water soluble cationic amide or ester compound obtained by reacting 5,6-dihydroxyindole-2carboxylic acid or an N-substituted derivative thereof with a quaternary salt having at least one reactive amino or hydroxyl group the quaternary salt having the structure ##STR3##wherein YH is a reactive amino or hydroxyl group; R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are alkyls of from 1 to 22 carbons, an amidoalkyl group, the alkyl having from 1 to 6 carbons, an alkyl- or dialkyl-substituted aryl or alicyclic group, the alkyl group(s) having from 1 to 6 carbons or a heterocyclic group selected from morpholinyl, piperindinyl or pyrrole, and R.sub.4 is alkylene group of from 1 to 20 carbons; an amidoallal group, the alkyl having from 1 to 6 carbons; an alkylene- or dialkylene-substituted aryl or alicyclic group, the alkylene group(s) having from 1 to 6 carbons, or a heterocyclic group selected from morpholinyl piperindinyl or pyrrole, each group R.sub.4, R.sub.1, R.sub.2, and R.sub.3 being unsubstituted or substituted with a substituent that does not prevent ester oramide formation, the substituents being selected from the groups consisting of hydroxy; mono- and polyhydroxyalkyl having from 1 to 4 carbons and from 1 to 3 hydroxyl groups; alkloxyl, mono- and polyhydroxyalkyloxy having from 1 to 4 carbons and from 0 to 3 hydroxy groups; amino and alkylamino having from 1 to 6 carbons in the alkyl group; amidoalkyl having from 1 to 6 carbons; halo; cyano, and nitro, and X is an anion.