Patent ID: 6087368
Filing Date: 2000-07-11
Classification: A61P,C07D

Abstract:
A compound of the following formula I or a salt thereof: ##STR143## where: X, Y and Z are defined such thatwhen X is --N(R.sub.9)-- and Y is --CH.dbd., Z is --N.dbd.;when X is --N(R.sub.9)-- and Y is --N.dbd., Z is --N.dbd. or --C(R.sub.9).dbd.;when Z is --N(R.sub.9)-- and Y is --CH.dbd., X is --N.dbd.;when Z is --N(R.sub.9)-- and Y is --N.dbd., X is --N.dbd. or --C(R.sub.9).dbd.;the dotted lines denote optional double bonds;R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, alkoxyalkyl, or haloalkyl;R.sub.2 is hydrogen, halo, cyano, nitro, --(CH.sub.2).sub.n --N.sub.3, --(CH.sub.2).sub.n --SO.sub.2 NR.sub.5 R.sub.6, --(CH.sub.2).sub.n --CO.sub.2 R.sub.7, --(CH.sub.2).sub.n --(C.dbd.O)NR.sub.5 R.sub.6, --(CH.sub.2).sub.n --NR.sub.5 R.sub.6, --(CH.sub.2).sub.n --NH (C.dbd.O)R.sub.8, or --(CH.sub.2).sub.n --NHSO.sub.2 R.sub.8 ;R.sub.3 and R.sub.4 are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, halo, aryl, arylalkyl, heterocyclo, heterocycloalkyl, --OR.sub.12 or --NHR.sub.12 ;R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each independently hydrogen, heterocyclo or alkyl wherein said alkyl is unsubstituted or substituted with a single substituent selected from --CO.sub.2 R.sub.10, hydroxy, amino, mono- or dialkylamino, and heterocyclo; orR.sub.5 and R.sub.6 may, together with the nitrogen to which they are bonded, form a five to seven membered unsubstituted heterocyclic ring or said heterocyclic ring having one or two substituents selected from alkyl, aryl, arylalkyl, heterocyclo, cycloalkyl, hydroxyalkyl, --(CH.sub.2).sub.n --CO.sub.2 R.sub.10, --N (R.sub.10)R.sub.11, --(CH.sub.2).sub.n --(CO) NR.sub.13 R.sub.14, --COR.sub.10, and --(CH.sub.2).sub.n --OR.sub.11 ;each R.sub.9 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocyclo, heterocycloalkyl, aryl or arylalkyl;R.sub.10, R.sub.11 and R.sub.12 are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, halo, aryl or arylalkyl;R.sub.13 and R.sub.14 are each independently hydrogen, hydroxy, alkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, arylalkyl, heterocycloalkyl, or heterocyclo, or R.sub.13 and R.sub.14 may, together with the nitrogen to which they are bonded, form a five to seven membered heterocyclic ring; andn is 0, 1, 2, 3 or 4;wherein cycloalkyl or cycloalkenyl alone or as part of another group may optionally be substituted by one, two, or three halo atoms, and wherein aryl alone or as part of another group may optionally be substituted by one, two, or three groups selected from halo, cyano, nitro, alkyl, amino, alkylamino, dialkylamino, and alkoxy.