Patent ID: 8101654
Filing Date: 2012-01-24
Classification: A61K,A61P

Abstract:
1. A method for delivering olopatadine or a pharmaceutically acceptable salt thereof to an anterior ocular segment of a mammalian subject, which comprises applying a percutaneously absorptive preparation comprising 5 to 30% by weight of olopatadine or a pharmaceutically acceptable salt thereof to the skin surface including the surface of an eyelid of the subject, thereby causing transfer of a therapeutically effective amount of olopatadine or a pharmaceutically acceptable salt thereof from the preparation to the anterior ocular segment of the subject, wherein the therapeutically effective amount of olopatadine or a pharmaceutically acceptable salt thereof is maintained in the anterior ocular segment of the subject for at least 8 hours, wherein the percutaneously absorptive preparation is an adhesive preparation, and wherein a base matrix for the adhesive preparation is selected from the group consisting of an acrylic pressure sensitive adhesive, a silicone pressure sensitive adhesive and a rubber pressure sensitive adhesive.