Patent ID: 8519112
Filing Date: 2013-08-27
Classification: A61K,C07K

Abstract:
1. An isolated nucleic acid molecule encoding a humanized immunoglobulin or antigen-binding fragment thereof comprising a) heavy chain complementarity determining regions as set forth in SEQ ID NO:29, SEQ ID NO:30, and SEQ ID NO:31, wherein the heavy chain further comprises at least one variable region framework residue from the monoclonal antibody 11K2 heavy chain set forth as SEQ ID NO: 27, wherein the residue is selected from the group consisting of L27, I29, and T73 (Kabat numbering convention) and b) light chain complementarity determining regions as set forth in SEQ ID NO:32, SEQ ID NO:33, and SEQ ID NO:34, wherein the light chain further comprises at least one variable region framework residue from the monoclonal antibody 11K2 light chain set forth as SEQ ID NO: 28, wherein the residue is selected from the group consisting of S49 and Y71 (Kabat numbering convention), wherein the remainder of the immunoglobulin or antigen-binding fragment is from a human immunoglobulin, wherein the immunoglobulin or antigen-binding fragment binds to MCP-1, MCP-2, or MCP-3.