Patent ID: 6706692
Filing Date: 2004-03-16
Classification: A61P,C07H

Abstract:
A compound selected from the group consisting of a compound of the formula wherein X is selected from the group consisting of â€”(NH)aâ€”, â€”CH2â€”, â€”SO2 and â€”Oâ€”, a is 0 or 1, Y is â€”(CH2)mâ€”(CH&boxH;CH)nâ€”(CH2)oâ€”, n is 0 or 1, m+n+o&lE;8, Ar is aryl or heteroaryl each unsubstituted or substituted with at least one member of the group consisting of a) â€”OH, halogen, â€”NO2, â€”CN, b) alkyl, alkenyl, alkynyl, â€”Oalkyl, â€”Oalkenyl, â€”Oalkynyl, â€”Salkyl, â€”Salkenyl, â€”Salkynyl, â€”Nalkyl, â€”Nalkenyl and â€”Nalkynyl, all of up to 12 carbon atoms, c) with Ra and Rb being individually hydrogen or alkyl of up to 12 carbon atoms and d) R3 is selected from the group consisting of unsubstituted or substituted alkyl of up to 12 carbon atoms, aryl and heteroaryl, heteroaryl having 5 to 6 ring members and containing at least one heteroatom, W is hydrogen or halogen, Z is hydrogen or acyl and its non-toxic, pharmaceutically acceptable acid addition salts.