Patent ID: 6384278
Filing Date: 2002-05-07
Classification: C07C

Abstract:
A method for preparing a carboxamide having the formula whereinR1, R2, R3, R4, and R5 are independently hydrogen, â€”OH, â€”Oâ€”R7, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, carboxyl, substituted or unsubstituted alkoxycarbonyl, halogen, nitrile, â€”OC(O)CH3, â€”SO3H, or â€”NR13R14; R6 is C1-C12 alkyl; R6 is optionally substituted with one or more alkenyl, alkoxycarbonyl, carboxyl, â€”OH, or halogen; R7 is hydrogen, alkyl, or aryl; and R13 and R14 are independently hydrogen, C1-C4 alkyl, or oxygen, the method comprising reacting(a) an aromatic amine having the formula (b) an acid in the presence of a boron containing compound to form the carboxamide, wherein the acid has the formula wherein R15 is a C1-C12 alkyl and R16 is an alkyl.