Patent ID: 6140341
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A compound of the formula (I), ##STR17## wherein: R.sup.1,R.sup.2,R.sup.3 identical or different, are(1) (C.sub.1 -C.sub.5)-alkyl,(2) (C.sub.6 -C.sub.10)-aryl,(3) (C.sub.1 -C.sub.3)-alkyl-(C.sub.6 -C.sub.10)-aryl,(4) halogen,(5) hydrogen,(6) (C.sub.3 -C.sub.8)-cycloalkyl,(7) CHO,(8) CO--O--(C.sub.1 -C.sub.3)alkyl, or(9) COOH;R.sup.4, R.sup.5 identical or different, are(1) hydrogen,(2) halogen,(3) (C.sub.1 -C.sub.3)-alkoxy,(4) nitro,(5) cyano, or(6) S--(C.sub.1 -C.sub.3)-alkyl;n is a number from 1 to 8;R.sup.6 is(1) hydrogen,(2) (C.sub.1 -C.sub.3)-alkyl,(3) (C.sub.3 -C.sub.5)-alkylalkenyl, or(4) (C.sub.1 -C.sub.3)-alkyl-(C.sub.6 -C.sub.10)-aryl;R.sup.7 is hydrogen or the following substituted or unsubstituted acyl radicals:(C.sub.1 -C.sub.6)-alkanoyl, (C.sub.1 -C.sub.3)-alkoxy-(C.sub.2 -C.sub.6)-alkanoyl, (C.sub.1 -C.sub.6)-alkylcarbamoyl-(C.sub.2 -C.sub.6)alkanoyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.2 -C.sub.6)-alkanoyl, (C.sub.3 -C.sub.7)-alkenoyl, (C.sub.3 -C.sub.8)-cycloalkylcarbonyl, (C.sub.5 -C.sub.7)-cycloalkenylcarbonyl, (C.sub.1 -C.sub.3)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryloxycarbonyl, (C.sub.6 -C.sub.12)-aroyl, (C.sub.1 -C.sub.3)-alkoxy-(C.sub.6 -C.sub.12)-aroyl, halogen-(C.sub.6 -C.sub.12)-aroyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.3)-alkoxy-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.3)-alkylenedioxy-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, nitro-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, cyano-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, halo-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, halo-(C.sub.1 -C.sub.3)-alkyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, hetero-(C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, amino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.4)-alkylamino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.2 -C.sub.5)-acylamino-(C.sub.6 -C.sub.12)-arylcinnamoyl, (C.sub.1 -C.sub.3)-alkoxycarbonylamino-(C.sub.6 -C.sub.12)-arylcinnamoyl, (C.sub.1 -C.sub.4)-alkylaminocarbonylaminocinnamoyl, hetero-(C.sub.6 -C.sub.12)-aryl-(C.sub.2 -C.sub.6)-alkanoylamino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.6 -C.sub.12)-aroylamino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, hetero-(C.sub.6 -C.sub.12)-arylcarbonylamino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.5)alkylsulfonylamino-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.5)-alkylureido-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.2 -C.sub.6)-alkanoyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.5)-alkoxycarbonyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.1 -C.sub.5)-alkylcarbamoyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoyl, (C.sub.6 -C.sub.12)-arylcarbamoyl-(C.sub.6 -C.sub.12)-aryl-(C.sub.3 -C.sub.6)-alkenoxyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkoxycarbonyl, (C.sub.1 -C.sub.5)-alkylcarbamoyl, (C.sub.6 -C.sub.12)-arylcarbamoyl, (C.sub.6 -C.sub.12)-aroylcarbamoyl, (C.sub.1 -C.sub.6)-alkylsulfonyl, (C.sub.6 -C.sub.12)-arylsulfonyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.6)-alkylsulfonyl, or R.sup.6 and R.sup.7 together represent a phthaloyl group which forms a ring with the nitrogen atom; or a physiologically toleratedsalt thereof.