Patent ID: 6121050
Filing Date: 2000-09-19
Classification: G01N,Y10T

Abstract:
An analyte detection system for determining the presence and/or concentration of glucose in a blood sample having two or more interfering components masking the presence and/or concentration of glucose in contact with a substrate having a blood application surface and an analyte detection surface wherein the presence and/or concentration of glucose cannot be directly determined comprising:a) means for introducing said blood sample onto said blood application surface;b) means for allowing said sample to migrate through said porous substrate to said analyte detection surface, wherein said detection surface includes a glucose-specific reagent and an indicator disposed thereon;c) means for forming a signal producing composition through the reaction of said glucose-specific reagent, said indicator and said glucose present in said blood sample;d) means for stimulating said sample with one or more stimuli;e) means for detecting one or more signals produced in response to d, and for correcting for any interfering signals produced by other analytes and/or two or more interfering components, wherein the number of stimuli required is equal to or greater than the sum of the number of analytes in said sample and any interfering components therein, provided that said stimuli for said interfering components are different from a stimulus for measuring said glucose and the interfering components must not simultaneously overlap at at least one correction point and further provided that said signal producing composition produces a measurable response having a characteristic ratio of signals at two different stimuli; andf) means for determining the presence and/or concentration of said glucose by applying a mathematical formula to said one or more signals.