Patent ID: 9222123
Filing Date: 2015-12-29
Classification: C12Q,G01N

Abstract:
1. An analytic device, comprising: a substrate comprising a first surface, wherein the first surface comprises a detection region; at least one optical waveguide disposed within the substrate, wherein the optical waveguide traverses the detection region, and wherein the optical waveguide receives optical energy from an optical energy source at a first end, and further wherein the optical waveguide is configured to have a gradually increasing confinement of the optical energy in a propagation direction of the optical energy such that the confinement is lower at the first end than in the detection region; and at least one nanometer-scale aperture in the detection region, wherein the nanometer-scale aperture penetrates into a first side of the substrate and extends toward a core of the optical waveguide such that a reaction site within the nanometer-scale aperture is sufficiently proximal to the core to be illuminated by an evanescent field emanating from the core when optical energy is passed through the optical waveguide.