Patent ID: 7943175
Filing Date: 2011-05-17
Classification: A61K,A61Q,B01J,B82Y,C07C,C07H

Abstract:
1. A pharmaceutically or cosmetically acceptable dispersible colloidal composition containing nanoparticles in the shape of matrix nanospheres, each said matrix nanosphere defining a molecular cavity, said nanospheres consisting essentially of at least one amphiphilically modified calixarene and having a size of from 50 to 500 nm, wherein the nanospheres are dispersed in a continuous phase containing water, and wherein said modified calixarene has the general formula wherein: RI=H, OH, OR or OCOR; R2=H, R, COR, CH2Pol, Y or CH2Y; R3=H, OH, OR or OCOR; R4=H, OR, OCH2R, OCOR or an ester, carboxylic acid, amido, amino, peptide or carbohydrate group; R5=R or Y; R=a saturated or unsaturated straight or branched hydrocarbon chain that may be substituted by halogen and/or by a group Pol; or R is a cyclic hydrocarbon radical, saturated or not; Pol=a polar group selected from phosphoric acid, sulfuric acid, amino, ammonium, carboxylic acid and their salts; Y=halogen or pseudo-halogen; X=a direct bond, 0, S or NR6R7 R6=allcyl R7=alkyl n=an integer of from 3 to 20; and n′=an integer≦n; the compound of the above formula containing at least one group Pol.