Patent ID: 6716982
Filing Date: 2004-04-06
Classification: C07D

Abstract:
A compound of Formula (II): wherein:R1 and R2 is selected from hydrogen, (C1-C8) alkyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl (C1-C8) alkyl, lower alkenyl, hydroxy (C1-C8) alkyl, or alkoxy alkyl, or (â€”CH2NR7R8), wherein: i) R7 and R8, which may be the same or different, are independently selected from hydrogen, (C1-C8) alkyl, (C3-7) cycloalkyl, (C3-7) cycloalkyl (C1-C8) alkyl, lower alkenyl, hydroxy (C1-C8) alkyl, or lower alkoxy (C1-C8) alkyl; or ii) R7 represents hydrogen, (C1-C8) alkyl, (C3-7)cycloalkyl, (C3-7) cycloalkyl (C1-C8) alkyl, lower alkenyl, hydroxy (C1-C8) alkyl, or lower alkoxy (C1-C8) alkyl, and R8 represents â€”COR9, wherein: R9 represents hydrogen, (C1-C8) alkyl, perhalo-(C1-C8) alkyl, (C3-7)cycloalkyl, (C3-7) cycloalkyl (C1-C8) alkyl, lower alkenyl, hydroxy(C1-C8) alkyl, lower alkoxy, lower alkoxy (C1-C8) alkyl; or iii) R7 represents hydrogen or (C1-C8) alkyl; and R8 represents diphenyl-methyl or â€”(CH2)t Ar wherein: t is 0 to 5 and Ar represents phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl optionally substituted with one or more substituents selected from hydroxy, methyl, halogen, and amino; or iv) R7 and R8 taken together with the linking nitrogen form a saturated 3 to 7 atom heterocyclic group of formula (IA) wherein:Y represents O, S, SO, SO2, CH2 or NR10, wherein: R10 represents hydrogen, (C1-C8) alkyl, perhalo (C1-C8) alkyl, aryl, aryl substituted with one or more substituents selected from (C1-C8) alkyl, lower alkoxy, halogen, nitro, amino, (C1-C8) alkyl amino, perhalo-(C1-C8) alkyl, hydroxy (C1-C8) alkyl, lower alkoxy (C1-C8) alkyl groups or â€”COR11, wherein: R11 represents hydrogen, (C1-C8) alkyl, perhalo-(C1-C8) alkyl, lower alkoxy, aryl, aryl substituted with one or more substituents selected from (C1-C8) alkyl, perhalo-(C1-C8) alkyl, hydroxy (C1-C8) alkyl, lower alkoxy (C1-C8) alkyl groups; R3 and R4 are independently selected from hydrogen, (C1-C8) alkyl, (C3-7)cycloalkyl, (C3-7) cycloalkyl (C1-C8) alkyl, lower alkenyl, hydroxy (C1-C8) alkyl, or alkoxy alkyl; or R3 and R4 taken together form a saturated 5 to 6 atom heterocyclic group of formula (IB) wherein, n represents the integer 1 or 2; or R3 represents â€”OCONR12R13, wherein, R12 and R13, which may be the same or different, are independently selected from hydrogen, a substituted or unsubstituted alkyl group with 1-4 carbon atoms or a substituted or unsubstituted carbocyclic or heterocyclic group, or R12 and R13 together with the nitrogen atom to which they are bonded form a heterocyclic ring which may be interrupted with â€”Oâ€”, â€”Sâ€” and/or â€”Nâ€”R14 in which R14 is hydrogen, a substituted or unsubstituted alkyl group with 1-4 carbon atoms or a substituted or unsubstituted phenyl group; R5 represents hydrogen or alkyl; and R6 represents hydrogen or alkyl, or a pharmaceutically acceptable salt thereof.