Patent ID: 9056152
Filing Date: 2015-06-16
Classification: A61F,A61K,A61L,C09D

Abstract:
1. A method of forming a coating comprising a drug on at least a portion of an outer surface of a medical device, the drug being a member of the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin, the method comprising the steps of: providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; providing crystals of the drug; grinding the crystals of the drug to form microcrystals of the drug having a maximum size of about 10 μm or less; applying the microcrystals of the drug to at least said portion of the outer surface of the device; and vapor annealing the coating of amorphous drug with a solvent vapor to form crystalline drug; the solvent selected from the group consisting of alcohols, acetonitrile, ethers, ketones solvents, halogenated solvents, aliphatic hydrocarbons, aromatic hydrocarbons, and ester solvents, wherein the microcrystals of the drug are applied before or after applying the drug solution, but prior to any vapor annealing of the coating of amorphous coating.