Patent ID: 7101840
Filing Date: 2006-09-05
Classification: A61K

Abstract:
1. A method of forming a polymeric drug formulation comprising: blending a water-soluble drug with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with said drug and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of said drug, said tissue-compatible polymer and said poly(alkylene oxide); and adding said solution to an amount of a non-solvent for said drug, said tissue-compatible polymer and said poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of said drug, said tissue-compatible polymer and said poly(alkylene oxide) is formed, wherein said poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.