Patent ID: 8658196
Filing Date: 2014-02-25
Classification: A61L,A61P

Abstract:
1. A multilaminate medical graft product, comprising: a first isolated tissue layer of remodelable collagenous extracellular matrix tissue material that promotes cellular invasion and ingrowth, said first tissue layer isolated from a biological tissue source; a second isolated tissue layer of remodelable collagenous extracellular matrix tissue material that promotes cellular invasion and ingrowth, said second tissue layer isolated from a biological tissue source, wherein said second tissue layer is bonded to said first tissue layer; a first bioactive component, wherein said first isolated tissue layer is enriched with said first bioactive component relative to said second isolated tissue layer; and a second bioactive component, wherein said second isolated tissue layer is enriched with said second bioactive component relative to said first tissue layer; and wherein said first bioactive component and said second bioactive component are each selected from the group consisting of basic fibroblast growth factor (FGF-2), transforming growth factor-beta (TGF-β), epidermal growth factor (EGF), platelet derived growth factor (PDGF), cartilage derived growth factor (CDGF), vascular endothelial growth factor (VEGF) an anti-clotting agent, an antibiotic agent, an anti-inflammatory agent, a therapeutic protein, and an anti-proliferative agent.