Patent ID: 6024958
Filing Date: 2000-02-15
Classification: A61K,A61P,C07K

Abstract:
A polypeptide or an extended polypeptide, wherein said extended polypeptide is extended at the N-terminus or C-terminus or both with non-wild-type amino acid sequence to form said extended polypeptide;wherein said polypeptide is selected from the group consisting ofa polypeptide consisting of an amino acid sequence corresponding to residues 925-1114 of the Streptococcus mutans antigen I/II (SA I/II) (SEQ ID NO: 1);a polypeptide consisting of an amino acid sequence corresponding to residues 1005-1044 of SA I/II (SEQ ID NO:2);a polypeptide consisting of an amino acid sequence corresponding to residues 1085-1104 of SA I/II (SEQ ID NO:3);a polypeptide consisting of an amino acid sequence corresponding to residues 1005-1114 of SA I/II (SEQ ID NO:4);a polypeptide consisting of an amino acid sequence corresponding to residues 925-1004 of SA I/II (SEQ ID NO:5);a polypeptide consisting of an amino acid sequence corresponding to residues 925-1054 of SA I/II (SEQ ID NO:6);a polypeptide consisting of an amino acid sequence corresponding to residues 803-854 of SA I/II (SEQ ID NO:7);a polypeptide consisting of an amino acid sequence corresponding to residues 975-1044 of SA I/II (SEQ ID NO:8);a polypeptide consisting of an amino acid sequence corresponding to residues 1024-1044 of SA I/II (SEQ ID NO:9);a polypeptide consisting of an amino acid sequence corresponding to residues 1025-1044 of SA I/II (residues 2-21 of SEQ ID NO:9);a polypeptide consisting of an amino acid sequence corresponding to residues 804-1114 of SA I/II (SEQ ID NO:10);a polypeptide consisting of an amino acid sequence corresponding to residues 975-1004 of SA I/II (SEQ ID NO:11); anda polypeptide which differs from any of the aforesaid polypeptides by up to and including 8 amino acid alterations wherein said alterations consist of the substitution and/or deletion and/or insertion of up to and including 8 amino acids and having the same immunological and adhesion properties as said corresponding sequence of any one of the aforesaid polypeptides; andwherein said polypeptide or extended polypeptide may be in the N-terminal acylated and/or C-terminal amidated form.