Patent ID: 8299104
Filing Date: 2012-10-30
Classification: A61K,A61P

Abstract:
1. A compound of the formula I, wherein: R1, R2 independently of one another H, (C o 0, 1, 2, 3, 4, 5, 6; q, s independently of one another 0, 1, 2, 3, 4; R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28 independently of one another H, (C R17 and R18, R23 and R24, R27 and R28 independently of one another optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C1-C6)-alkyl, oxygen and sulfur; R12 OH, O—(C u 0, 1,2; R34, R35 independently of one another H, (C R34 and R35 optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C R36, R37 H, (C R13, R14 independently of one another H, (C R29, R30, R31 independently of one another H, (C R32, R33 independently of one another H, (C or R32 and R33 optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C R3 H, (C R4, R5 independently of one another H, (C R6, R7, R8, R9 independently of one another H, (C or R6 and R7, R8 and R9 independently of one another optionally oxo; n, m are 1; A, B, D, G independently of one another C(R38); R38 H, F, Cl, Br, I, OH, CF R39, R40, R41, R42, R43, R45 independently of one another H, (C or R39 and R40, R41 and R42 independently of one another optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C R44, R46, R47 independently of one another H, (C R48, R49 independently of one another H, (C R50 H, (C x 1, 2, 3, 4; Het represents 1,2,4-oxadiazolyl; X a bond, a group of the formula —(CR51R52) Y O, S, N(R53), CO, SO, SO R51, R52 independently of one another H, (C y 1, 2, 3, 4, 5, 6; R53 H, (C E 3-14 membered bivalent carbo- or heterocyclic ring structure having 0-4 heteroatoms from the group of N, O and S, which may optionally have substituents from the group of H, F, Cl, Br, I, OH, CF R54, R55, R56, R57, R58, R60 independently of one another H, (C R54 and R55, R56 and R57 independently of one another optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C R59, R61, R62 independently of one another H, (C K a bond, a group of the formula —(CR63R64) Z O, S, N(R65), CO, SO, SO R63, R64 independently of one another H, (C z 1, 2, 3, 4, 5, 6; R65 H, (C R11 H, (C R66, R67, R68, R69, R70, R71, R72 independently of one another H, (C or R67 and R68, R71 and R72 independently of one another optionally together with the nitrogen atom to which they are bonded a 5-6 membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms from the group of NH, N—(C N-oxides thereof and physiologically tolerated salts thereof.