Patent ID: 6072073
Filing Date: 2000-06-06
Classification: C07B,C07C

Abstract:
A process for preparing an alpha-arylated or -vinylated carbonyl compounds, comprising the step of:reacting a compound having at least one carbonyl group and an atom alpha to said carbonyl group bearing at least one hydrogen atom with an arylating or vinylating compound selected from the group consisting of ketone, amides, esters, carboxylic acids, thioesters, amidines, anhydrides, .beta.-dicarbonyl compounds, .alpha.-dicarbonyl compounds, malononitriles, compounds with carbonyl groups .beta.- to sulfoxides, sulfones, phosphates, phosphate esters, and nitriles in the presence of a base and a transition metal catalyst under reaction conditions effective to form said alpha-arylated or vinylated carbonyl compound, said transition metal catalyst having the formula:X.sub.n M(ER.sub.1-4).sub.mwherein X is an optional ligand, M is a group 8 transition metal, E is an element bearing a nonbonding electron pair when E is not bonded to the metal, and R is a substituent bonded to E through a carbon, nitrogen, oxygen, or sulfur atom, with the proviso that R.sub.3 cannot contain 3 aryl groups, n is an integer from 0 to 4, and m is an integer from 1-4.