Patent ID: 6468766
Filing Date: 2002-10-22
Classification: A01K,A61K,C07K,C12N,C12Y,G01N

Abstract:
An isolated nucleic acid molecule comprising a nucleotide sequence, said nucleotide sequence encoding a polypeptide comprising an amino acid sequence which is at least 87% identical to SEQ ID NO:2 over the entire length of SEQ ID NO: 2 and which amino acid sequence comprises(a) a discoidin domain comprising amino acids 385-540 of SEQ ID NO:2; (b) a lysine-rich/proline-rich domain comprising amino acids 117-164 of SEQ ID NO:2; and (c) a carboxypeptidase domain comprising amino acids 562-969 of SEQ ID NO:2, wherein an amino acid substitution in said polypeptide is conservative with respect to SEQ ID NO:2 and wherein the absence of said polypeptide is associated with gastroschisis.