Patent ID: 8748105
Filing Date: 2014-06-10
Classification: C07K,C40B,G01N

Abstract:
1. A method for synthesizing a compound comprising at least one peptide structure attached via at least two thioether linkages to a (hetero)aromatic molecule, the method comprising: providing a (hetero)aromatic molecule comprising a bis-, tris-, or tetrakis(halomethyl)-substituted (hetero)aromatic ring system; providing at least one peptide comprising at least one amino acid having a side chain comprising an unprotected functional group selected from the group consisting of amine, guanidinium, amido, carboxylic acid, alcohol, phenol, indole, thioether, and imidazole, wherein the peptide further comprises at least two SH functionalities; and contacting the (hetero)aromatic molecule and the at least one peptide in a buffered aqueous solution comprising at least 50% water, to form in a coupling reaction the compound comprising at least one peptide structure attached via at least two thioether linkages to the (hetero)aromatic molecule, wherein each of the thioether linkages is formed between one of the halomethyl substituents on the (hetero)aromatic ring system and one of the SH functionalities.