Patent ID: 6482404
Filing Date: 2002-11-19
Classification: A01K,A61K,C07K,C12N

Abstract:
A method of transplanting non-human donor tissue into a recipient mammal, wherein the donor tissue is from a non-human mammal of a different species from the recipient, the donor species being a discordant species with respect to the recipient, the method comprising grafting the donor tissue into the recipient, wherein said donor tissue is from a transgenic non-human mammal comprising transplantable tissue and whose genome comprises a DNA sequence or DNA sequences coding for a peptide or peptides having complement inhibiting activity of one or more homologous complement restriction factors (HCRFs) and said DNA sequence or DNA sequences are expressed in at least some of the cells of said tissue, wherein expression of said DNA sequence, or DNA sequences, results in transplantable tissue which inhibits complement mediated xenograft rejection on transplantation into or exposure to a component or components of the immune system of a discordant species.