Patent ID: 6458789
Filing Date: 2002-10-01
Classification: C07D

Abstract:
A single compound of the formula: wherein:one of R1 and R2 is selected from the group consisting of C1 to C12 alkyl, C2 to C12 alkenyl, C2 to C12 alkynyl, C1 to C12 substituted alkyl, C2 to C12 substituted alkenyl, C2 to C12 substituted alkynyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, heteroaryl, substituted heteroaryl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy and protected carboxy; and the other of R1 and R2 is selected from the group consisting of heteroaryl, substituted heteroaryl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 heteroalkylene and substituted cyclic C2 to C7 heteroalkylene; R3 and R4 are, independently, selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, C2 to C12 alkynyl, C2 to C12 substituted alkynyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C12 alkylaminocarbonyl, C1 to C12 substituted alkylaminocarbonyl, heterocyclic ring and substituted heterocyclic ring, or the group consisting of (i) the formula â€”C(O)R6; (ii) the formula â€”C(O)OR6; (iii) the formula C(O)NHR6; (iv) the formula C(O)NR6R7; and (v) the formula â€”S(O2)R6, wherein R6 and R7 are, independently, selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, C2 to C12 alkynyl, C2 to C12 substituted alkynyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, heterocyclic ring and substituted heterocyclic ring, or R3 and R4, together with the adjoining nitrogen atom depicted in the formula, form a heterocyclic ring or substituted heterocyclic ring, wherein said ring is pyrrolidino; provided that R2 is also selected from the group consisting of heterocyclic ring and substituted heterocyclic ring; provided that R2 cannot be phenyl; R5is selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C2 to C12 alkenyl, C2 to C12 alkynyl, C1 to C12 substituted alkyl, C2 to C12 substituted alkenyl, C2 to C12 substituted alkynyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, heteroaryl, substituted heteroaryl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy, protected carboxy or cyano, or R5 combines with R1 to form a substituent selected from the group consisting of C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, heterocyclic ring and substituted heterocyclic ring, wherein said ring is non-aromatic; provided that the compound thereof does not contain four or more carboxy groups; and provided that both R3 and R4 are not hydrogen atoms; or a pharmaceutically acceptable salt of the compound thereof.