Patent ID: 8476243
Filing Date: 2013-07-02
Classification: A61P,C12N

Abstract:
1. A method of treating a hyperproliferation skin disorder in a subject who is manifesting a hyperproliferation disorder, comprising: administering to the subject who is manifesting a hyperproliferation disorder selected from the group consisting of keratosis pilaris, calluses, corns, psoriasis, keratosis follicularis, pityriasis rubra pilaris, and Clouston syndrome, a therapeutically effective amount of an RNA sequence which inhibits expression of a gene encoding for a keratin selected from the group consisting of K6a, K6b, K16, K17, and combinations thereof, wherein the inhibited gene encodes the K6a keratin and the RNA sequence is a member selected from the group consisting of: SEQ. ID NO: 2, SEQ. ID NO: 4, SEQ. ID NO: 6, SEQ. ID NO: 8, SEQ. ID NO: 10, SEQ. ID NO: 12, SEQ. ID NO: 14, SEQ. ID NO: 16, SEQ. ID NO: 18, SEQ. ID NO: 20, SEQ. ID NO: 86, SEQ. ID NO: 91, SEQ. ID NO: 92, SEQ. ID NO: 94, and combinations thereof.