Patent ID: 8912341
Filing Date: 2014-12-16
Classification: C07D

Abstract:
1. A method of preparing a bicyclic lactone compound, said method comprising: providing a mixture of a heterocyclic alkylidene imidazolidinone, a triazolium N-heterocyclic carbene catalyst precursor compound and a base component, said alkylidene imidazolidinone of a formula wherein Ar is selected from aryl and substituted aryl moieties, said Ar substituents selected from alkyl, alkoxy, halo and haloalkyl substituents and combinations thereof, and R 1 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl and cycloalkyl moieties, said R 1 substituents selected from alkyl, alkoxy, halo and haloalkyl substituents and combinations thereof; and introducing to said mixture an α,β-unsaturated aldehyde in the presence of an acid component, said aldehyde of a formula  wherein R