Patent ID: 7759303
Filing Date: 2010-07-20
Classification: C07H,C07K,C12N,C12P

Abstract:
1. A method for improving the folding efficiency and solubility of a target protein covalently linked to an RNA-binding protein comprising: reacting an RNA molecule as a molecular chaperone with a target protein covalently linked to an RNA-binding protein, wherein the RNA-binding protein is selected from the group consisting of Lysyl-tRNA synthetase, C5 protein of ribonuclease P, Ffh protein of signal recognition particle, NP protein of influenza virus, ribosomal S1 protein, ribosomal S4 protein, ribosomal S17 protein, DbpA, Hsp15, DnaK, and murine Hsc70; and the RNA molecule binds to the RNA-binding protein.