Patent ID: 6369069
Filing Date: 2002-04-09
Classification: A61P,C07C

Abstract:
A compound of the formula (I), in which the symbols have the following meaning:R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine; 3. alkenyl having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; 4. â€”CnH2nâˆ’nnâ€”Y, nn is zero or 2; and n is zero, 1, 2, 3 or 4; where n is unequal to zero or 1 if nn is equal to 2; or 5. â€”CnH2nâˆ’nnâ€”Y, nn is zero or 2; and n is 1, 2, 3 or 4; where n is unequal to 1 if nn is equal to 2; where 1, 2 or 3 hydrogen atoms in the divalent radical â€”CnH2nâˆ’nnâ€” independently of one another are replaced by a radical from the group consisting of 1. aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; 2. amino; 3. NR(22)R(23); 4. alkoxycarbonyl; 5. COOR(16); 6. alkyl having 1, 2, 3 or 4 carbon atoms; and 7. (C6-C14)-aryl-(C1-C4)-alkylcarbonyl; R(2)is 1. hydrogen; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 3. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine; 4. alkenyl having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; 5. alkynyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 6. â€”CnH2nâˆ’nnâ€”Z, nn is zero or 2; and n is zero, 1, 2, 3 or 4; where n is unequal to zero or 1 if nn is equal to 2; or 7. â€”CnH2nâˆ’nnâ€”Z, nn is zero or 2; and n is 1, 2, 3 or 4, where n is unequal to 1 if nn is equal to 2; where 1, 2 or 3 hydrogen atoms in the divalent radical â€”CnH2nâˆ’nnâ€” independently of one another are replaced by a radical from the group consisting of 1. aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; 2. amino; 3. NR(22)R(23); 4. (C1-C4)-alkoxycarbonyl; 5. COOR(16); and 6. alkyl having 1, 2, 3 or 4 carbon atoms; R(3) and R(4) independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(5), R(6) and R(7) independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3,â€”CN, â€”NO2, SOqâ€”R(8), COâ€”R(21) or Oâ€”R(10); R(8) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, NR(11)R(12) or phenyl which is unsubstituted or is substituted by 1, 2 or 3 identical or different radicals from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(11)R(12); R(9) and R(21) independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or OR(13); R(10) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms which is unsubstituted or substituted by (C1-C4)-alkoxy; or phenyl which is unsubstituted or is substituted by 1, 2 or 3 identical or different radicals from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(11)R(12); R(11), R(12), R(19) and R(20) independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or (C1-C4)-alkanoyl; R(13) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; X is carbonyl, â€”COâ€”NHâ€”, â€”COâ€”COâ€” or sulfonyl; Y and Z independently of one another are 1. aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; 2. a radical as defined in 1., which is substituted by 1, 2, 3, 4 or 5 identical or different radicals from the group consisting of alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms, F, Cl, Br, I, CF3, SOqR(18), OR(16), NR(19)R(20), â€”CN, NO2 and COâ€”R(9); or where two radicals together form a fused heterocyclyl radical; 3. heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms; 4. a radical as defined in 3., which is substituted by 1, 2 or 3 identical or different radicals from the group consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl and NR(11)R(12); 5. cycloalkyl having 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms; 6. a radical as defined in 5., substituted by aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; 7. Oâ€”R(14); 8. Oâ€”R(17); 9. â€”SO2â€”R(14); 10. arylalkylcarbonyl; or 11. heterocyclyl; R(14) and R(17) independently of one another are 1. hydrogen; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 3. alkenyl having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; 4. â€”CnH2nâˆ’nn-phenyl, nn is zero or 2; and n is zero, 1, 2, 3 or 4; where n is unequal to zero or 1 if nn is equal to 2; or 5. a radical as defined in 4., where the phenyl group is substituted by 1, 2 or 3 identical or different radicals from the group consisting of alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, SOqR(15), OR(16), NR(11)R(12), â€”CN, â€”NO2 and COâ€”R(9); R(15) and R(18) independently of one another are alkyl having 1, 2, 3 or 4 carbon atoms, alkyl having 1, 2, 3 or 4 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine, or NR(11)R(12); R(16) is 1. hydrogen, 2. alkyl having 1, 2, 3 or 4 carbon atoms, 3. alkyl having 1, 2, 3 or 4 carbon atoms, substituted by (C1-C4)-alkoxy, 4. alkyl having 1, 2, 3 or 4 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine; 5. aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; or 6. a radical as defined in 5., which is substituted by 1, 2 or 3 identical or different radicals from the group consisting of F, Cl, Br, I, CF3, NR(19)R(20), â€”CN, and NO2; R(22) and R(23) independently of one another are hydrogen or COâ€”OR(24); R(24) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or â€”CnH2n-phenyl where n is equal to 1, 2, 3 or 4; and q independently of one another is zero, 1 or 2; or a physiologically tolerable salt thereof.