Patent ID: 8802090
Filing Date: 2014-08-12
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for treating colorectal or pancreatic carcinoma-associated pathologies comprising administering to a subject an effective amount of an antibody selected from the group consisting of a monoclonal, Fab, Fab′, F(ab′)2, and Fv, that binds 16C3 colorectal and pancreatic carcinoma-associated antigens (16C3 CPAA), wherein said antibody comprises a. a light chain, said light chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 4; (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 5; and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 6, and b. a heavy chain, said heavy chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO: 7; (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 10; and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO: 9 or SEQ ID NO: 11.