Patent ID: 9024015
Filing Date: 2015-05-05
Classification: C07D

Abstract:
1. A process for the preparation of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine, comprising: a) reacting 7-chloro-4-ethoxycarbonyl-5-oxo-N-p-toluenesufonyl-2,3,4,5-tetrahydro-1H-benzazepine with sulfuric acid; b) maintaining the contents obtained in step (a) at above 50° C. to form reaction mass; c) cooling the first reaction mass obtained in step (b) at room temperature; d) pouring the reaction mass into water; e) adjusting the pH of the reaction mass to about 7.0 to 8.5 with a base; and f) isolating 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine from the reaction mass.