Patent ID: 9156814
Filing Date: 2015-10-13
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating beta-amyloid (Aβ) peptides aggregation-associated diseases and preventing development and progression of said diseases due to increased Aβ aggregates-induced neurotoxicity by administering carbazole-based fluorophores comprising formula S or V series, said method comprising: binding said carbazole-based fluorophores to Aβ peptides, oligomers and fibrils thereof; inhibiting the growth and/or aggregation of said Aβ peptides, oligomers and/or fibrils upon said binding; and protecting neuronal cells against the neurotoxic activities of the Aβ oligomers and/or fibrils; wherein in said carbazole-based fluorophores, Ar is a heteraromatic ring selected from the group consisting of pyridinyl, substituted pyridinyl, quinolinyl, substituted quinolinyl, acridinyl, substituted acridinyl, benzothiazolyl, substituted benzothiazolyl, benzoxazolyl, and substituted benzoxazolyl; R R R X is selected from the group consisting of F