Patent ID: 6677355
Filing Date: 2004-01-13
Classification: A61P,C07C,C07D

Abstract:
A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein X is selected from OH and NHOH; d is 1 or 2;R1 is selected from the group consisting of: â€ƒwherein Y is selected from the group consisting of O; R5 is selected from the group consisting of H, C1-10 alkyl, CF3, CONH2, halo, CN, COOH, C1-4 alkoxy, CHO, NO2, OH, (CH2)pOH, (CH2)pNH2, Ar, and NH2; R2 is selected from the group consisting of (a) hydrogen; (b) C1-4 alkyl; (c) benzyl; and (d) benzyl substituted with one or more of C1-4 alkyl, C1-4 alkoxy, F, Cl, Br, I, NH2, NO2, CN, carboxy, and CO2R7 (where R7 is H or C1-4 alkyl); and R3 and R4 are either (1) each independently selected from the group consisting of C1-20 alkyl; C3-10 cycloalkyl; phenyl; phenyl substituted with C1-4 alkyl, C1-4 alkoxy, halo, NH2, NO2, CN, COOH, CO2R7, or CF3; C3-10 heterocyclic; and heteroaryl; or (2) substituents taken together to form a group of the empirical formula â€”(CH2)sZgâ€”, wherein said substituents form a ring including the carbon atom adjacent the carbonyl group in Formula I, and wherein s is an integer from 2 to 10; g is 0 to 6; and each Z is located at any position of said substituents and each Z is independently selected from the group consisting of O, S, and NR8 (where R8 is selected from H and C1-3 alkyl).