Patent ID: 7445767
Filing Date: 2008-11-04
Classification: A61K,C09B

Abstract:
1. An in-vivo diagnostic near infrared radiation method comprising: (a) administering a compound of the general formula I wherein L represents a number from 1 to 6 n represents a number from 0 to 10, and m represents a number from 1 to 100; B is a biological detecting unit having a molecular weight of up to 30,000 that bonds to specific cell populations or selectively to receptors, or accumulates in tissues or tumours, or generally stays in the blood, or is a macromolecule that bonds non-selectively; F represents a cyanine dye of the general formula IIa wherein r represents the numbers 0, 1 or 2, wherein, for r=2, the respective L R is a halogen atom, a hydroxy, carboxy, acetoxy, amino, nitro, cyano or sulfonic acid group or an alkyl, alkenyl, hydroxyalkyl, carboxyalkyl, alkoxy, alkoxycarbonyl, sulfoalkyl, alkylamino, dialkylamino or halogenalkyl group containing up to 6 carbon atoms, aryl, alkylaryl, hydroxyaryl, carboxyaryl, sulfoaryl, arylamino, diarylamino, nitroaryl or halogenaryl group containing up to 9 carbon atoms, or where R represents a bond that bonds to another group R and forms a 4−to 6-member ring together with the interspersed groups L R X and Y are the same or different, each independently representing an O, S, Se or Te or a —C(CH3)2—, —CH═CH—or —CR where R W represents a hydrophilic group that improves water-solubility, with n-octanol-water distribution coefficient of the compound according to formula I being less than or equal to 2.0 for 1=0; as well as a physiologically tolerable salt, W being selected from the group consisting of (i) a carboxy or sulfonic acid group; (ii) a carboxyalkyl group; and (iii) an alkoxycarbonyl or alkoxyoxoalkyl group containing up to 12 carbon atoms, wherein W takes the position of (i) both R (b) irradiating the compound with light in the near infrared range; and (c) recording the radiation produced by the compound.