Patent ID: 8877195
Filing Date: 2014-11-04
Classification: A61P,C07K,G01N

Abstract:
1. An isolated antibody that binds human fibrin or fibrinogen γC domain, and inhibits Mac-1 binding to fibrin or fibrinogen γC domain, wherein the antibody light chain comprises three complementarity determining regions comprising the amino acid sequences of RSSKSLLHSSGITYLS (SEQ ID NO:2), QMSNLAS (SEQ ID NO:3), and AQNLELPLT (SEQ ID NO:4), respectively, and the antibody heavy chain comprises three complementarity determining regions comprising the amino acid sequences of GYTFTSYWIH (SEQ ID NO:6), LIDPSDSYTNYNQKFRG (SEQ ID NO:7), and SDPTGC (SEQ ID NO:8), respectively.