Patent ID: 8450462
Filing Date: 2013-05-28
Classification: A61K,A61P,C07K

Abstract:
1. A compound represented by general formula (1-1): wherein, A is a single-chain antibody moiety, which is a polypeptide comprising an antigen-binding site; L is a linker moiety, which is a polypeptide comprising a protease cleavage site; Y is a peptide moiety, which comprises 1 or more amino acids connecting the linker moiety L with the single-chain antibody moiety A; and the linker moiety L binds to an N terminus of the peptide moiety Y, and the peptide moiety Y binds to an N terminus of the single-chain antibody moiety A in (1-1), and wherein L-Y-A (1-1) comprises a polypeptide comprising either one of the amino acid sequences of SEQ ID NO: 4 and SEQ ID NO: 7.