Patent ID: 8828976
Filing Date: 2014-09-09
Classification: A61K,A61P,C07C,C07D,C12Q,G01N

Abstract:
1. A method of altering the fidelity of eukaryotic translation initiation codon selection, the method comprising administering to a cell a compound of Formula I-V: where n is an integer from 1 to 4; R 1 is H, halogen, alkyl, NO 2 , OR 3 , N(R 4 ) 2 , or SR 5 ; R 2 is H or alkyl; R 3 is H or alkyl, and R 4 is H or alkyl and R 5 is H or alkyl; where X 1 is Br or I; R 6 is H, halogen, alkyl, NO 2 , OR 3 , N(R 4 ) 2 , or SR 5 ; R 3 is H or alkyl, and R 4 is H or alkyl and R 5 is H or alkyl; where X 2 is F, Cl, Br, or I; R 7 is H or alkyl; where X 3 is F, Cl, Br, or I; R 8 is H or alkyl; R 9 is H or alkyl; where R 10 is H or alkyl and R H is H or alkyl; and pharmaceutically acceptable salts thereof.