Patent ID: 8326389
Filing Date: 2012-12-04
Classification: A61B

Abstract:
1. A system for in vivo biosensing of one or more target analyte molecules in a subject, the system comprising: at least one implant member configured to be completely implanted in the subject's body and to be exposed to the one or more target analyte molecules in the subject's body, the implant member including a reflective substrate having deposited thereon at least one biocompatible polymer comprised of at least one polyaniline or oligomer thereof, and at least one sensitizing agent; the sensitizing agent configured to cause an oxidation-reduction reaction with the polymer in the presence of the target analyte molecule; the biocompatible polymer configured to immobilize the sensitizing agent without covalent bonding and to accept electrons sufficient to alter the biocompatible polymer's optical properties and to provide a detectable signal; at least one reader member separate from the implant member and configured to be at least temporarily positioned external to the subjects' body and adjacent to the implant member, the reader member being configured: i) to emit light having one or more specific wavelengths, and ii) to detect a reflected signal from the implant member; and at least one data system configured to determine a concentration of the target analyte molecule.