Patent ID: 8476319
Filing Date: 2013-07-02
Classification: A61K,A61P

Abstract:
1. A method of treating otitis media in a subject, the method comprising delivering an antimicrobial composition across the tympanic membrane and/or tympanic membrane surrounding tissue to the middle ear by contacting the tympanic membrane, and/or tympanic membrane surrounding tissue with the antimicrobial composition comprising: an effective amount of an antimicrobial lipid component having a solubility in water of no greater than 1.0 gram per 100 grams deionized water and comprising an antiseptic selected from the group of a (C7-C14)saturated fatty acid monoester of glycerol, a (C7-C14)saturated fatty acid monoester of propylene glycol, a (C8-C22)unsaturated fatty acid monoester of glycerol, a (C8-C22)unsaturated fatty acid monoester of propylene glycol, an alkoxylated derivative of any of the foregoing having a free hydroxyl group, and combinations thereof; wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of glycerol or propylene glycol; and an effective amount of a penetration agent, wherein the penetration agent promotes the diffusion of the antimicrobial component into the middle ear; wherein the fatty acid esters or alkoxylate derivatives thereof comprise less than 15 wt-% di- or tri-esters based on the total weight of the antimicrobial lipid component; and wherein the viscosity of the composition is less than 20 cps at 23° C.