Patent ID: 7186401
Filing Date: 2007-03-06
Classification: A61K,A61P

Abstract:
1. A method of producing a dry powder formulation for inhalation, said formulation having a fine particle fraction (FPF) with reduced sensitivity to penetrating moisture, and comprising a pharmaceutically inactive carrier comprising particles of noninhalable size and a pharmaceutically active component comprising at least one finely-divided pharmaceutically active compound comprising particles of inhalable size; said method comprising: mixing together (i) said pharmaceutically inactive carrier; (ii) said pharmaceutically active component; and (iii) pulverulent magnesium stearate, in an amount of 0.1 to 2% by weight, based on the total weight of the formulation, said amount being effective to provide the FPF with reduced sensitivity to penetrating moisture and to stabilize the dry powder formulation.