Patent ID: 7619111
Filing Date: 2009-11-17
Classification: C07B,C07C

Abstract:
1. A stereoselective method for preparing a fluorinated molecule having a fluorine atom carried by an asymmetric carbon atom having the (R) or (S) configuration, located a to an ester or ketone group, said method comprising: (i) introducing into a reactor a single enantiomer of a fluorosulfite compound having a given configuration at the C* carrying the fluorosulfite group, of formula (III) (2i) conducting thermal decomposition of the fluorosulfite compound in the presence of a nucleophilic catalyst, and (3i) recovering the resulting single enantiomer fluorinated molecule, having the inverse configuration at the C*, of formula (IV) wherein: C* represents a chiral carbon; R n is an integer from 1 to 12; R or R R R R