Patent ID: 6350860
Filing Date: 2002-02-26
Classification: A61K,C07K

Abstract:
An isolated molecule which binds and neutralizes interferon-gamma selected from the group consisting of:a scFv comprising a humanized variable domain, wherein said variable domain comprises amino acids 1-117 and 133-239 of SEQ ID) NO: 85; a chimeric antibody comprising: a) a humanized heavy chain variable domain, said heavy chain variable domain having an amino acid sequence as shown in positions 1-117 of SEQ ID NO: 85, and b) the humanized light chain variable domain, said light chain variable domain having an amino acid sequence as shown in positions 133-239 of SEQ ID NO: 85; a diabody comprising: a) a humanized heavy chain variable domain, said heavy chain variable domain having an amino acid sequence as shown in positions 1-117 of SEQ ID NO: 85, and b) a humanized light chain variable domain, said light chain variable domain having an amino acid sequence as shown in positions 133-239 of SEQ ID NO: 85; and, a multivalent antibody, wherein said multivalent antibody is selected from the group consisting of a triabody, a tetravalent antibody, a peptabody, and a hexabody, and wherein said multivalent antibody comprises: a) a humanized heavy chain variable domain, said variable domain comprising amino acids 1-117 of SEQ ID NO: 85; and b) a humanized light chain variable domain, said variable domain comprising amino acids 133-239 of SEQ ID NO: 85.