Patent ID: 7662387
Filing Date: 2010-02-16
Classification: A61K,A61P,C07K

Abstract:
1. A method for the treatment of a CD70-expressing cancer in a subject, the method comprising: administering to the subject, in an amount effective for the treatment thereof, an antibody-drug conjugate comprising an antibody that binds to CD70, wherein: (i) the drug is a cytotoxic agent, (ii) the antibody is a mouse antibody comprising a heavy chain variable region having the amino acid sequence set forth in residues 20 to 137 of SEQ ID NO:2, and a light chain variable region having the amino acid sequence set forth in residues 21 to 132 of SEQ ID NO:12, or a chimeric or humanized form of the mouse antibody, and (iii) the antibody-drug conjugate is internalized into cells, where it exerts a therapeutic effect.