Patent ID: 6025140
Filing Date: 2000-02-15
Classification: A61K,C07K,C12N

Abstract:
A membrane-permeable construct for transport across a lipid membrane comprising:a nucleic acid analog which hybridizes with an intracellular polynucleotide;a peptide comprisingR.sub.1 -INLKALAALAKKIL-R.sub.2 (SEQ ID NO: 1)wherein each of R.sub.1 and R.sub.2 is a peptide, an amino acid, NH.sub.2, H, or OH, at least one of R.sub.1 and R.sub.2 is a peptide, and said nucleic acid analog is bonded to the one of R.sub.1 and R.sub.2 that is a peptide; anda labile bond linking the nucleic acid analog and the peptide.