Patent ID: 7560540
Filing Date: 2009-07-14
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule that encodes a human or murine B7-DC protein, wherein the B7-DC protein is selectively expressed on dendritic cells as compared to activated macrophages, wherein murine B7-DC protein has 32% homology to human B7-H1, wherein the B7-DC protein comprises single IgV and IgC domains, wherein the B7-DC protein comprises a single transmembrane domain, wherein the B7-DC protein comprises an intracytoplasmic tail 4 amino acids in length, wherein the B7-DC protein does not bind to CD28 or CTLA-4 and does not include the CD28/CTLA-4 binding motifs, and wherein the B7-DC protein is capable of co-stimulating T cells.