Patent ID: 8697348
Filing Date: 2014-04-15
Classification: A61P,C07K,C12Q,G01N

Abstract:
1. A method of detecting an imatinib-resistant mutant abl kinase domain in a Bcr-Abl polypeptide in an individual, the method comprising the steps of: a) obtaining a sample containing a DNA or RNA coding for a Bcr-Abl polypeptide, or obtaining a sample containing a Bcr-Abl polypeptide, from the individual; and b) detecting the presence in the sample of at least one mutation in the Bcr-Abl polypeptide corresponding to an amino acid position of SEQ ID NO: 1 selected from the group consisting of Q252H, D276N, T277P, M278K, E292G, L298M, V299L, V304A, V304D, F311L, M343V, M343T, E355G, L364H, V379I and H396K, wherein the presence of the at least one mutation indicates that the individual has a Bcr-Abl polypeptide having an imatinib-resistant mutant abl kinase domain, the method of detecting comprising the steps of: