Patent ID: 8198457
Filing Date: 2012-06-12
Classification: A61P,C07D

Abstract:
1. A method of treating a subject with a hyperproliferative disease comprising administering to the subject an effective amount of a MEK inhibitor, wherein the hyperproliferative disease is related to the hyperactivity of MEK and diseases modulated by the MEK cascade in mammals, and wherein the MEK inhibitor is a compound according to of Formula (II): or a pharmaceutically acceptable salt thereof, wherein: R R R R R R R R′, R″ and R″′ are independently selected from: hydrogen, C R″″ is selected from: C W is —C(O)OR provided that W is not —C(O)OH; R R X is N or N m is 0, 1, 2, 3, 4 or 5; and j is 1 or 2; with the proviso that 3-phenylamino-isonicotinic acid methyl ester and 3-oxo-3-(3-phenylamino-pyridin-4-yl)-propionic acid ethyl ester are not included.