Patent ID: 6649620
Filing Date: 2003-11-18
Classification: A61P,C07D

Abstract:
A compound of formula I, whereinR1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents an aryl group selected from phenyl or naphthyl or a heteroaryl group selected from pyridinyl or furanyl, each aryl or heteroaryl group optionally substituted by C1-4 alkyl or SO2NH2; R3 represents a heterocyclic ring selected from morpholine, thiomorpholine-1,1-dioxide, 1,4-dioxan, tetrahydrofuran, piperidine, optionally fused to a benzene or pyridine ring, or 1,4-benzodioxane, each ring system as a whole being optionally substituted by one or more groups independently selected from OH, C1-4 alkyl, C1-4 alkoxy, halogen and NHSO2(C1-4 alkyl); X represents N; and L is absent, or represents a cyclic group of formula Ia, â€ƒin which A is attached to R3; A represents CO or SO2; Z represents CH or N; m represents 1 or 2, and in addition, when Z represents CH, it may represent 0; and n represents 1, 2 or 3, provided that the sum of m and n is 2,3,4 or 5; or represents a chain of formula Ib, â€ƒin which A is attached to R-hu 2; A and Z are as defined above; R4 and R5 independently represent H or C1-4 alkyl; and p represents 1, 2 or 3, and in addition, when Z represents CH, it may represent 0; or a pharmaceutically acceptable salt thereof.