Patent ID: 6187337
Filing Date: 2001-02-13
Classification: A61K

Abstract:
A rapidly dissolving pharmaceutical dosage form, comprising:a particulate support matrix comprising a first polypeptide component having a predetermined net charge, a second polypeptide component having a predetermined net charge of the same sign as the net charge of the first polypeptide component, and a bulking agent, and wherein the first polypeptide component and the second polypeptide component together comprise about 2% to 35% by weight of the particulate support matrix and wherein the bulking agent comprises about 45% to 97% by weight of the particulate support matrix, and wherein the second polypeptide component has a solubility in aqueous solution greater than that of the first polypeptide component; anda pharmaceutical ingredient;and wherein when the dosage form is introduced into an aqueous environment the support matrix is substantially completely disintegrable within less than about 20 seconds.