Patent ID: 7788045
Filing Date: 2010-08-31
Classification: A61K,A61P

Abstract:
1. A method of increasing blood hemoglobin concentration in a patient requiring such treatment, comprising: (a) determining hemoglobin concentration (Hb) in a patient's blood sample; (b) determining the ideal blood volume (IBV) of the patient; (c) determining a first red cell mass value corresponding to the patient's hemoglobin concentration based on a predetermined mean cell hemoglobin concentration (MCHC) parameter; (d) determining a target red cell mass (tRCM-B) of the patient based on the predetermined MCHC; (e) calculating a therapeutically effective amount of packet red blood cells for transfusion into a patient to increase the patient's red cell mass to approximately the tRCM-B level, wherein the therapeutically effective amount is directly proportional to k, wherein k is equivalent to about 30% of the IBV value, further wherein the therapeutically effective amount of packet red blood cells (PRBC) is defined by the mathematical formula: wherein steps (a) to (d) can occur in any order; and (f) administering to the patient the calculated therapeutically effective amount of packet red blood cells thereby increasing the hemoglobin concentration in the patient's blood.