Patent ID: 7566706
Filing Date: 2009-07-28
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of formula 1; or a therapeutically effective amount of a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and a compound of formula 1: wherein independently for each occurrence: W is oxygen or sulfur; Q is oxygen, NR, N(acyl) or a bond; X R for each occurrence is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, and heteroaralkyl; R R R wherein R 17 is selected independently from the group consisting of hydrogen, halide, hydroxyl, alkoxyl, aryloxy, acyloxy, amino, alkylamino, arylamino, acylamino, aralkylamino, nitro, acylthio, carboxamide, carboxyl, nitrile, —COR 18 , —CO 2 R 18 , —N(R 18 )CO 2 R 19 , —OC(O)N(R 18 )(R 19 ), —N(R 18 )SO 2 R 19 , —N(R 18 )C(O)N(R 18 )(R 19 ), and —CH 2 O-heterocyclyl; R R R R R R R p is 1,2,3,4,5, or 6; R R R R R provided that when R the absolute stereochemistry at a stereogenic center of formula 1 may be R or S or a mixture thereof and the stereochemistry of a double bond may be E or Z or a mixture thereof; and wherein the cancer is: breast cancer, multiple myeloma, Hodgkin lymphoma, non-Hodgkin lymphoma, acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, chronic myeloid leukemia, malignant melanoma, lung cancer, colon cancer, ovarian cancer, or myelodysplastic syndrome.