Patent ID: 6406850
Filing Date: 2002-06-18
Classification: C07H,C12Q

Abstract:
A method for preventing hybridization of a repetitive chromosomal nucleic acid sequence, while permitting hybridization of a unique chromosomal nucleic acid sequence, the method comprising the steps of:providing a nucleic acid sequence that is complementary to the repetitive sequence, wherein the complementary sequence or the repetitive sequence or both comprise a cross-linking agent, the cross-linking agent being capable of cross-linking the complementary sequence to the repetitive sequence when the complementary sequence is hybridized to the repetitive sequence; and hybridizing the repetitive nucleic acid sequence to its complementary sequence in the presence of the unique sequence, thereby cross-linking the complementary sequence to the repetitive sequence; whereby the cross-linked repetitive sequence is prevented from further hybridizing, while the unique sequence is permitted to hybridize.