Patent ID: 6797269
Filing Date: 2004-09-28
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of inhibiting a T-cell response to an antigen, comprising;culturing mesenchymal stem cells in the presence of IFN-&ggr;; modifying said mesenchymal stem cells to present said antigen by contacting said mesenchymal stem cells with said antigen in vitro, wherein said mesenchymal stem cells do not produce co-stimulatory molecules in a sufficient amount to activate T-cells, whereby said mesenchymal stem cells present said antigen; and administering to a host said modified mesenchymal stem cells, thereby inhibiting a T-cell response to said antigen upon subsequent exposure of the T-cells to antigen presenting cells which express co-stimulatory molecules.