Patent ID: 8927009
Filing Date: 2015-01-06
Classification: A61K,A61P

Abstract:
1. A pharmaceutical capsule comprising a capsule shell having encapsulated therewithin, in an amount not greater than about 1000 mg per capsule, a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof at an ABT-263 free-base equivalent concentration of at least about 40 mg/ml in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycolides, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant, and (d) at least one sulfur-containing antioxidant in an amount effective to reduce oxidative degradation of ABT-263 upon storage.