Patent ID: 7166578
Filing Date: 2007-01-23
Classification: A61K,A61P,C07K

Abstract:
1. A method of stimulating the formation and cycling of pre-beta high density lipoprotein-like particles in a mammal, said method comprising: administering to said mammal a peptide or a concatamer of a peptide that: ranges in length up to about 30 amino acids; comprises at least one class A amphipathic helix; protects a phospholipid against oxidation by an oxidizing agent; and comprises the amino acid sequence D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F (SEQ ID NO. 5); wherein said peptide is administered in a concentration sufficient to stimulate the formation and cycling of pre-beta high density lipoprotein like particles.