Patent ID: 6710057
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A compound of formula I (or a pharmaceutically acceptable salt thereof) wherein:A3, A4, A5 and A6, together with the two carbons to which they are attached, complete a substituted benzene in which A3 is CR3, A4 is CR4, A5 is CR5, and A6 is CR6; whereinR3 is hydrogen; one of R4 and R5 is hydrogen, methyl, fluoro, chloro, RfO2Câ€”, or RgNHâ€”; the other of R4 and R5 is hydrogen; and R6 is hydrogen; in which Rf is hydrogen, (1-4C)alkyl or benzyl; Rg is hydrogen, or RhSO2â€”; and Rh is (1-4C)alkyl or dimethylamino; L1 is â€”NHâ€”COâ€”, â€”COâ€”NHâ€” or â€”CH2â€”NHâ€” such that â€”L1â€”Q1 is â€”NHâ€”COâ€”Q1 â€”COâ€”NHâ€”Q1 or â€”CH2â€”NHâ€”Q1; Q1 is 2-pyridyl-, the 2-pyridyl may bear an amino substituent at the 6-position; and R2 is â€”NHâ€”CH2â€”Q2 in which Q2 is Q2A wherein Q2A (showing the â€”CH2â€” to which it is attached) is in whichR2A is hydrogen, t-butyl, methylsulfonyl, or â€”CHRWRX wherein each of RW and RX independently is hydrogen or (1-3C) normal alkyl.