Patent ID: 6419949
Filing Date: 2002-07-16
Classification: A61K,Y10S

Abstract:
Compositions suitable to oral administration for transmucosal absorption and to intravenous administration for overcoming of the blood-brain barrier and the blood-cerebrospinal fluid barrier, comprising aqueous dispersions of microparticles having an average diameter ranging from 40 to 150 nm and a polydispersion index ranging from 0.15 to 0.28, said microparticles consisting of one or more lipids, a drug and, optionally, a stabilizing agent selected from the group consisting of dipalmitoyl phosphatidyl ethanolamine-PEG, PEG-stearate, esters of the fatty acids from myristic acid to docosanoic acid with methyl ether PEG, diacylphosphatidyl ethanolamines esterified with methyl ether PEG and polylactates and polyglycolactates esterified with methyl ether PEG, said microparticles prepared by dispersing in an aqueous medium, cooled at 2 to 4Â° C., an oil in water or a water/oil/water microemulsion warmed at a temperature near the melting temperature of the lipids, washing with water by diafiltration and freeze-drying.