Patent ID: 6365617
Filing Date: 2002-04-02
Classification: A61P,C07D

Abstract:
A compound of the following formula (I): wherein:R1 is selected from the group consisting of amino, C1-C8 alkylamino, C1-C8 dialkylamino, arylamino, arC1-C8 alkylamino, C3-C8 cycloalkylamino, heteroalkylC1-C8 alkylamino, heteroalkyl C1-C8 alkyl-N-methylamino, C1-C8 dialkylamino C1-C8 alkylamino, â€”N(C1-C8alkyl)â€”C1-C8alkyl-N(C1-C8alkyl)2, â€”N(C1-C8 alkyl)(C1-C8 alkenyl), â€”N(C1-C8alkyl)(C3-C8cycloalkyl), heteroalkyl and substituted heteroalkyl, wherein the substituent on the heteroalkyl is selected from oxo, amino, C1-C8 alkoxy, C1-C8 alkyl, C1-C8 alkylamino or C1-C8 dialkylamino; R2 is selected from the group consisting of unsubstituted or substituted aryl, arC1-C8 alkyl, C3-C8cycloalkyl and heteroaryl, wherein the substituents on the aryl, aralkyl, cycloalkyl or heteroaryl group are independently selected from the group consisting of one or more of halogen, nitro, amino, cyano, hydroxyalkyl, C1-C8 alkyl, C1-C8 alkoxy, C1-C8alkoxycarbonyl, acetyl, fluorinated C1-C4 alkyl, fluorinated C1-C4 alkoxy and C1-C4 alkylsulfonyl; R3 is selected from the group consisting of H and C1-C8 alkyl; R4 and R5 are each independently selected from the group consisting of H, C1-C8 alkyl, aminoC1-C8 alkyl, amidinoC1-C8 alkyl, guanidinoC1-C8 alkyl, aryl, arC1-C8 alkyl, substituted aryl, substituted arC1-C8, alkyl, heteroaryl, heteroarylC1-C8 alkyl, substituted heteroaryl, substituted heteroarylC1-C8 alkyl, C3-C6 cycloalkyl and substituted C3-C6cycloalkyl, wherein the substituents on the aryl, aralkyl, cycloalkyl or heteroaryl group are independently selected from the group consisting of one or more of halogen, nitro, amino, amidino, guanidino, cyano, hydroxyalkyl, C1-C8alkyl, C1-C8alkoxy, C1-C8alkoxycarbonyl, acetyl, fluorinated C1-C4 alkyl, fluorinated C1-C4 alkoxy and C1-C4 alkylsulfonyl; R6 and R7 are each independently selected from the group consisting of H, C1-C8 alkyl, aminoC1-C8 alkyl, aminoC3-C8 cycloalkyl, amidinoC1-C8 alkyl, guanidinoC1-C8 alkyl, aryl, substituted aryl, arC1-C8 alkyl, substituted arC1-C8 alkyl, heteroarylC1-C8 alkyl and substituted heteroarylC1-C8 alkyl, wherein the one or more substituents on the aryl, aralkyl, cycloalkyl or heteroaryl group are independently selected from the group consisting of halogen, nitro, amino, amidino, guanidino, cyano, hydroxyalkyl, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, acetyl, fluorinated C1-C4 alkyl, fluorinated C1-C4 alkoxy and C1-C4 alkylsulfonyl; R8 is selected from the group consisting of H, C1-C8 alkyl, amino C1-C8 alkyl, allyl, C3-C8 cycloalkyl, substituted C3-C8 cycloalkyl, aryl, substituted aryl, C1-C8 alkyl, substituted arC1-C8 alkyl, heteroaryl, substituted heteroaryl, heteroarylC1-C8 alkyl and substituted heteroarylC1-C8 alkyl, wherein the one or more substituents on the aryl, aralkyl, cycloalkyl or heteroaryl group are independently selected from the group consisting of halogen, nitro, amino, amidino, guanidino, cyano, hydroxyalkyl, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, acetyl, fluorinated C1-C4 alkyl, fluorinated C1-C4 alkoxy and C1-C4 alkylsulfonyl; X is CH or N; n is an integer selected from the group consisting of 0, 1, 2 and 3; m is an integer selected from the group consisting of 0 and 1; and p is an integer selected from the group consisting of 1 and 2; provided that when m is 1, then one of R5 or R7 must be hydrogen; provided further that when R5 is hydrogen, then R4 cannot be hydrogen; and, when R7 is hydrogen, then R6 cannot be hydrogen; and pharmaceutically acceptable salts thereof.