Patent ID: 8841334
Filing Date: 2014-09-23
Classification: A61P,C07D

Abstract:
1. A compound according to formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R R R R then R 1 is A or A-alkylene-; and with a further proviso that when R R R R R R A is a 4-, 5-, 6-, 7-, 8-, or 9-membered monocyclic heterocycle containing zero or one double bond, one or two oxygen, and zero or one nitrogen as ring atoms; two non-adjacent atoms of said heterocycle ring can be optionally linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms; or A is furanyl, oxazolyl, isoxazolyl, or oxadiazolyl; each ring A is optionally fused with a monocyclic ring selected from the group consisting of benzo, cycloalkyl, cycloalkenyl, heterocycle and heteroaryl; and each A is independently unsubstituted or substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; L R the aryl, cycloalkyl, cycloalkenyl, heterocycle, or heteroaryl moieties, as a substituent, or as part of a substituent, as represented by R G 1 , —NZ 1 Z 2 , —(CR 41 R 42 ) p —NZ 1 Z 2 , and (NZ 3 Z 4 )carbonyl; G oxo, —OR 51 , —OC(O)R 51 , —OC(O)N(R 51 ) 2 , —S(O) 2 R 52 , —S(O) 2 N(R 51 ) 2 , —C(O)R 51 , —C(O)OR 51 , —C(O)N(R 51 ) 2 , —N(R 51 ) 2 , —N(R 51 )C(O)R 51 , —N(R 51 )S(O) 2 R 52 , —N(R 51 )C(O)O(R 52 ), —N(R 51 )C(O)N(R 51 ) 2 , —(CR 1c R 1d ) q —OR 51 , —(CR 1c R 1d ) q —OC(O)R 51 , —(CR 1c R 1d ) q —OC(O)N(R 51 ) 2 , —(CR 1c R 1d ) q —S(O) 2 R 52 , —(CR 1c R 1d ) q —S(O) 2 N(R 51 ) 2 , —(CR 1c R 1d ) q —C(O)R 51 , —(CR 1c R 1d ) q —C(O)OR 51 , —(CR 1c R 1d ) q —C(O)N(R 51 ) 2 , —(CR 1c R 1d ) q —N(R 51 ) 2 , —(CR 1c R 1d ) q —N(R 51 )C(O)R 51 , —(CR 1c R 1d ) q —N(R 51 )S(O) 2 R 52 , —(CR 1c R 1d ) q —N(R 51 )C(O)O(R 52 ), —(CR 1c R 1d ) q —N(R 51 )C(O)N(R 51 ) 2 , and —(CR 1c R 1d ) q —CN; R R the monocyclic cycloalkyl moiety, as a substituent, or as part of a substituent, as represented by R R m, p, q, and u, at each occurrence, are each independently 1, 2, 3, or 4; Z Z