Patent ID: 6358955
Filing Date: 2002-03-19
Classification: C07D

Abstract:
A compound of the formula: R1 is aryl, heteroaryl, arylalkyl, cycloalkyl or napthyl; unsubstituted or substituted by up to 3 substituents which are the same or different and represent hydrogen, halogen, trifluoromethyl, cyano, straight or branched chain lower alkyl having 1-6 carbon atoms, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms, or SO2R9 where R9 is H2 or NHCH3; X is N or NR2 where R2 is hydrogen or methyl; Y is N or CR3 Z is CR3 or N provided that Y and Z are not both CR3; and provided that Y and Z are not both N; R3 is hydrogen, lower alkyl, halogen, hydroxy, lower alkyl or phenyl unsubstituted or substituted by up to three substituents which are the same or different and represent hydrogen, halogen trifluoromethyl, cyano, sulfonamido, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; R4 is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms, or R3 and R4 together represent â€”(CH2)n1â€” where n1 is 2, 3 or 4; or R2 and R4 together represent â€”(CH2)n2â€” where n2 is 2, 3 or 4; m is zero, one or two; R5 and R6 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, straight or branched chain lower alkyl having 1-6 carbon atoms or R2 and R5 together represent â€”(CH2)n3â€” where n3 is 2 or 3; or NR5R6 together represent 2-(1,2,3,4-tetrahydroisoquionolinyl), either unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; or NR5R6 represents where R7 is phenyl, benzyl, or phenethyl with the phenyl ring unsubstituted or substituted with up to three substituents which are the same or different and represent hydrogen, halogen, trifluoromethyl, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; or NR5R6 represents where p is 1, 2, or 3; W is N or CH; and W is N and R8 is hydrogen, phenyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; or W is CH and R8 is phenyl, or phenylalkyl each of which is unsubstituted or substituted at the phenyl ring with up to three substituents independently selected from hydrogen, halogen, trifluoromethyl, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms.