Patent ID: 8697662
Filing Date: 2014-04-15
Classification: A61K,A61P

Abstract:
1. A method for treating a Kaposi sarcoma (KS), comprising administering to a human having the KS an effective amount of a compound having Formula (II): or a pharmaceutically acceptable salt, racemate or stereoisomer thereof, wherein, X is hydrogen; C R R wherein amino is optionally substituted with C wherein alkylamino and dialkylamino are each optionally substituted on alkyl with hydroxyl, C wherein morpholinyl, thiomorpholinyl, pyrrolidinyl, piperidinyl, piperazinyl and oxiranyl are each optionally substituted with —C(O)—R R R R R wherein administering the compound to the human produces one or more of the results selected from the group consisting of: (i) decrease in the number of previously existing KS lesions in the human relative to the number of KS lesions observed prior to administration of the compound; (ii) decrease in the number of raised KS lesions in the human relative to the number of raised KS lesions observed prior to administration of the compound; (iii) complete flattening of one or more previously raised KS lesions in the human; and (iv) decrease in the sum of perpendicular diameters of a KS lesion in the human, relative to the sum of perpendicular diameters in the KS lesion observed prior to administration of the compound.