Patent ID: 8119775
Filing Date: 2012-02-21
Classification: A61P,C07K

Abstract:
1. An isolated human antibody that binds to each one of human KIR2DL1, human KIR2DL2, and human KIR2DL3, but which does not bind human KIR2DS4, said human antibody comprising: (a)(i) a heavy chain CDR1 amino acid sequence corresponding to residues 31-35 of SEQ ID NO:17; (a)(ii) a heavy chain CDR2 amino acid sequence corresponding to residues 50-65 of SEQ ID NO:17; (a)(iii) a heavy chain CDR3 amino acid sequence corresponding to residues 99-112 of SEQ ID NO:17; (a)(iv) a light chain CDR1 amino acid sequence corresponding to residues 24-34 of SEQ ID NO:15; (a)(v) a light chain CDR2 amino acid sequence corresponding to residues 50-56 of SEQ ID NO:15; and (a)(vi) a light chain CDR3 amino acid sequence corresponding to residues 89-97 or SEQ ID NO:15; or (b) a VL region comprising SEQ ID NO: 15 and a VH region comprising SEQ ID NO: 17.