Patent ID: 6500845
Filing Date: 2002-12-31
Classification: A61K,A61P,C07D

Abstract:
A method of treating a condition selected from the group consisting of Graft-versus-Host-Syndrome, transplant or graft rejection, Morbus Behcet, erythema nodosum leprosum, Morbus Boeck, rheumatoid fever, rheumatoid arthritis, lupus erythematodes, stomatitis aphthosa, autoimmune consequences of chronic infections, Morbus Crohn, multisystem vasculitis, late infection reaction, and mucocutaneous ulcerations in a mammal, said method comprising administering to said mammal a lactam derivative corresponding to formula I whereinX is CH2, S or Se; R is a C1-6-alkyl group or a benzyl group; and Z and Zâ€² are different and denote CH2 or CO, or Z and Zâ€² are both CO; with the proviso that when X is CH2, R is not CH3, or Z and Zâ€² are not both CO, in racemic or in optically active form in an amount effective to attenuate cytokine release without eliminating immunocompetence.