Patent ID: 6110945
Filing Date: 2000-08-29
Classification: A61P,C07D

Abstract:
A compound of formula (1): ##STR6## wherein: Az is an optionally substituted pyridyl group;R.sup.1 is an optionally substituted phenyl group or an optionally substituted pyridyl group;Alk.sup.1 is an optionally substituted aliphatic or heteroaliphatic chain;L.sup.1 is an --O--or --S--atom or a --C(O)--, --C(O)O--, --C(S)--, --S(O)--, --S(O).sub.2 --, --S(O)2O--, --N(R.sup.8)--, --CON(R.sup.8)--, --OC(O)N(R.sup.8)--, --CSN(R.sup.8)--, --N(R.sup.8)CO--, --N(R.sup.8)C(O)O--, --N(R.sup.8)CS--, --S(O).sub.2 N(R.sup.8)--, --N(R.sup.8)S(O).sub.2 --, --N(R.sup.8)CSN(R.sup.8)-- or --N(R.sup.8)SO.sub.2 N(R.sup.8) group (where R.sup.8 is a hydrogen atom or an optionally substituted straight or branched alkyl group);r and s is each zero or an integer 1;Alk.sup.2 is a straight or branched alkylene chain;m is zero or an integer 1;R.sup.4 is a hydrogen atom or a methyl group;R.sup.5 is a group --L.sup.2 (CH.sub.2).sub.t R.sup.6 where L.sup.2 is a --N(R.sup.7)CO-- or --N(R.sup.7)CS-- group (where R.sup.7 is a hydrogen atom or a straight or branched alkyl (group), t is zero or the integer 1 and R.sup.6 is an optionally substituted pyrrolidinyl, thiazolidinyl, pyridyl or phenyl group;R is a carboxylic acid (--CO.sub.2 H) group or a derivative thereof;or a pharmaceutically acceptable salt or a solvate or hydrate thereof.