Patent ID: 7943340
Filing Date: 2011-05-17
Classification: A61K,A61P,C07K,C12N,C12P,C12Q,G01N

Abstract:
1. A method for removing an aminoterminal Xaa-Pro tag from a protein, wherein Xaa is any amino acid, comprising the steps of: (1) purification of the protein by covalent capture, and, (2) contacting the protein with a polypeptide comprising an amino acid sequence which is at least 95% identical to SEQ ID NO: 35, or a fragment thereof, wherein said polypeptide or fragment has dipeptidyl peptidase IV activity, wherein the DPPIV activity consists of cleavage of the aminoterminal Xaa-Pro tag of the protein such that the aminoterminal Xaa-Pro is removed.