Patent ID: 7067110
Filing Date: 2006-06-27
Classification: A61K,C07K,C12N

Abstract:
1. A method for eliciting an immune response against an antigen in a mammal, the method comprising: administering to the mammal intramuscularly, intravenously, transdermally or subcutaneously, a fusion protein comprising an antigen linked by a polypeptide bond to an immunoglobulin heavy chain constant region whose ability to bind an Fc receptor is not modified by mutation, thereby to elicit an immune response against the antigen, wherein the fusion protein lacks an immunoglobulin variable domain and the antigen is selected from the group consisting of Prostate-Specific Membrane Antigen, an ectodomain of a cytokine receptor, a viral protein and a tumor-specific protein, the antigen of the fusion protein eliciting a stronger immune response in the mammal than the antigen alone.