Patent ID: 6369087
Filing Date: 2002-04-09
Classification: A61K,A61P,C07D,G01N

Abstract:
A compound represented by the formula (Ia) in a solid state: wherein:Sx represents a chiral sulfur atom comprising at least one of the diastereomers represented by Sxa and Sxb, wherein Sxa is the (âˆ’) diasteromer and Sxb is the (+) diasteromer; R is alkoxy; R1 is selected from the group consisting of hydrogen, alkyl, halogen, carboalkoxy, alkoxy, and alkanoyl; R2 is hydrogen or alkyl; and R3, R4, and R5 may be the same or different and are each selected from the group consisting of hydrogen, alkyl, alkoxy, and alkoxyalkoxy, wherein when R4 is alkoxy and R3 and R5 are not hydrogen, the alkyl substituent of such alkoxy group is selected from the group consisting of at least one of the diastereomers represented by R4q and R4z, wherein R4q is the (âˆ’) diastereomer and lies above the chiral plane; and R4z is the (+) diastereomer and lies below the chiral plane; or one or more pharmaceutically acceptable salts, hydrates, or combinations thereof; subject to the proviso that racemic mixtures are excluded when R is methoxy, R1 is hydrogen, R2 is hydrogen, R3 is methyl, R4 is methoxy and R5 is methyl for the compound represented by formula (Ia).