Patent ID: 7067309
Filing Date: 2006-06-27
Classification: A61K,C07K,C12N

Abstract:
1. An adenoviral vector which is defective for replication, capable of being encapsidated in a complementation cell, and which is derived from an adenoviral genome comprising, from 5′ to 3′, a 5′ ITR, an encapsidation region, an E1A region, an E1B region, an E2 region, an E3 region, an E4 region and a 3′ ITR, by deletion of all or part of the E1A region, all or part of the E4 region, and all of the E3 region, and which comprises a gene of interest placed under the control of the elements needed for its expression in a host cell; and further comprising a gene coding for a protein which trans-activates non-adenoviral transcription wherein said gene is placed under the control of the elements needed for the expression of said protein in a host cell.