Patent ID: 7935348
Filing Date: 2011-05-03
Classification: A61K,A61M,A61P

Abstract:
1. A method for treating Alzheimer's disease in a person, comprising: administering to the person an agent for inducing an efflux of amyloid β (Aβ) from the brain to the plasma of the person, wherein said agent is an Aβ-mimotope comprising a peptide selected from the group consisting of EIDYHR (SEQ ID NO: 2), ELDYHR (SEQ ID NO: 3), EVDYHR (SEQ ID NO: 4), DIDYHR (SEQ ID NO: 5), DLDYHR (SEQ ID NO: 6), DVDYHR (SEQ ID NO: 7), DIDYRR (SEQ ID NO: 8), DLDYRR (SEQ ID NO: 9), DVDYRR (SEQ ID NO: 10), DKELRI (SEQ ID NO: 11), DWELRI (SEQ ID NO: 12), YREFFI (SEQ ID NO: 13), YREFRI (SEQ ID NO: 14), YAEFRG (SEQ ID NO: 15), EAEFRG (SEQ ID NO: 16), DYEFRG (SEQ ID NO: 17), ELEFRG (SEQ ID NO: 18), DRELRI (SEQ ID NO: 19), DKELKI (SEQ ID NO: 20), DRELKI (SEQ ID NO: 21), GREFRN (SEQ ID NO: 22), EYEFRG (SEQ ID NO: 23), DWEFRDA (SEQ ID NO: 24), SWEFRT (SEQ ID NO: 25), DKELR (SEQ ID NO: 26), SFEFRG (SEQ ID NO: 27), DAEFRWP (SEQ ID NO: 28), DNEFRSP (SEQ ID NO: 29), SAEFRTQ (SEQ ID NO: 32), SAEFRAT (SEQ ID NO: 33), SWEFRNP (SEQ ID NO: 34), SWEFRLY (SEQ ID NO: 35), SWELRQA (SEQ ID NO: 36), SVEFRYH (SEQ ID NO: 37), SYEFRHH (SEQ ID NO: 38), SQEFRTP (SEQ ID NO: 39), SSEFRVS (SEQ ID NO: 40), DWEFRD (SEQ ID NO: 41), DAELRY (SEQ ID NO: 42), DWELRQ (SEQ ID NO: 43), SLEFRF (SEQ ID NO: 44), GPEFRW (SEQ ID NO: 45), and GKEFRT (SEQ ID NO: 46); and treating said person with an apheresis device to maintain the Aβ efflux, wherein said apheresis device comprises a solid carrier comprising an amyloid-β-precursor protein binding receptor (APP-binding receptor), wherein said APP-binding receptor is selected from the group consisting of gelsolin, an anti-Aβ antibody, an anti-APP antibody, apolipoprotein J (apoJ), apolipoprotein E (apoE), and GM1 ganglioside, and wherein said APP-binding receptor binds and removes Aβ from the plasma when said solid carrier of said apheresis device is brought into contact with the plasma of said person.