Patent ID: 7235375
Filing Date: 2007-06-26
Classification: C07K,G01N

Abstract:
1. A method of identifying a compound that is transported by an OATP2 (organic anion transport protein 2) protein comprising the amino acid sequence of SEQ ID NO: 2, said method comprising the steps of: (a) contacting a cell expressing OATP2 protein with said compound, under conditions which permit the movement of said compound across the cell membrane; (b) contacting a control cell that lacks OATP2 protein with said compound, under said conditions of step (a); and (c) determining the presence of said compound inside the cell expressing OATP2 protein and inside the cell that lacks OATP2 protein, wherein the presence or a greater quantity of said compound inside the cell expressing OATP2 protein as compared to the cell that lacks OATP2 protein indicates said compound is transported by OATP2.