Patent ID: 6815213
Filing Date: 2004-11-09
Classification: G01N,G01R,H01J,Y10T

Abstract:
A process for the analysis of a sample of a complex molecule relative to a reference batch of the same complex molecule so as to determine their degree of similarity and/or the nature of their process of production, comprising:cleaving the complex molecule into at least two molecular sub-entities, in that, if necessary, at least one of the cleavage products is cleaved into at least two new molecular sub-entities and in that this cleavage operation is repeatable on the molecular sub-entities until analyzable and isolable molecular sub-entities are obtained, in that there is determined, as a function of the atomic sites of the cleavage products in question, by generally chemical cleavage reactions, the isotope or isotopes to be studied, in that there is established, for at least a portion of the cleavage products, their isotopic profile at least by nuclear magnetic resonance NMR for the measurement of the specific positional isotopic content and in that the isotopic profile of the cleavage products is compared to the isotopic profile of primary materials already cataloged and taking part in the synthesis process of the reference complex molecule and/or in the isotopic profile of the cleavage products of the reference complex molecule subjected to the same cleavage reactions.