Patent ID: 6815426
Filing Date: 2004-11-09
Classification: A61K,C07K

Abstract:
An angiogenesis-inhibitory tripeptide of formula aa1-aa2-aa3, having a first amino acid (aa1), a second amino acid (aa2) and a third amino acid (aa3), wherein:(a) said first amino acid is selected from the group consisting of Ser, Thr, Ala, Phe, Tyr, Cys, Gly, Leu, Lys, Pro, Arg, Gln, Glu, Asp, Asn, His, Met, Ile, Trp, Val, diaminoproprionic acid and trans-4-hydroxy-proline; (b) said second amino acid is selected from the group consisting of Asn, Ala, Gly, Asp, Glu, Gln diaminoproprionic acid and trans-4-hydroxy-proline; and (c) said third amino acid is selected from the group consisting of Ser, Thr, Ala, Phe, Tyr, Cys, Gly, Leu, Lys, Pro, Arg, Gln, Glu, Asp, Asn, His, Met, Ile, Trp, Val, diaminoproprionic acid and trans-4-hydroxy-proline; and wherein the tripeptide is not Arg-Gly-Asp, Asn-Gly-Arg, or Gly-Ser-Leu.