Patent ID: 8558005
Filing Date: 2013-10-15
Classification: A61P,C07D

Abstract:
1. A process for the production of 2-halo-4-nitroimidazole wherein the halogen is Cl or Br, comprising the steps of: (i) nitration of 4-nitroimidazole to obtain 1,4-dinitroimidazole with the aid of nitric acid in a mixture of acetic acid and acetic anhydride; (ii) thermally rearranging 1,4-dinitroimidazole into 2,4-dinitroimidazole without isolating and drying operations; and (iii) reacting 2,4-dinitroimidazole wetted with a solvent with a chlorinating or bromating agent to obtain 2-halo-4-nitroimidazole.