Patent ID: 8178834
Filing Date: 2012-05-15
Classification: G06K,G16C,H01J

Abstract:
1. A method of LC/IMS/MS analysis, comprising: obtaining, from a sample, noisy raw data comprising a set of three-dimensional data elements each associating an ion-count intensity with a retention-time dimension, an ion-mobility dimension, and a mass-to-charge-ratio dimension, wherein the noise is associated with ion-peak artifacts; collapsing, in the ion-mobility dimension, the set of data elements to obtain a set of collapsed data elements each associating a combined ion-count intensity with the retention-time and mass-to-charge-ratio dimensions; convolving the set of collapsed data elements with an artifact-reducing filter associated with a two-dimensional matrix, thereby obtaining a convolved set of collapsed data elements having reduced peak artifacts; locating, in the retention-time and mass-to-charge-ratio dimensions, ion peaks of the convolved set of collapsed data elements; selecting one or more portions of the noisy raw data for further analysis, in response to the located ion peaks of the convolved set of collapsed data elements; convolving the selected one or more portions of the noisy raw data with an artifact-reducing filter associated with a three-dimensional matrix; and locating, in the ion mobility dimension, one or more ion peaks for each convolved portion of the raw data.