Patent ID: 6627643
Filing Date: 2003-09-30
Classification: A61K,A61P,C07D

Abstract:
A method of preparing a compound of formula Iâ€²comprising:combining a mixture of acetonitrile and a compound of formula IXâ€²with thionyl chloride to form a mixture comprising a compound of formula Xâ€²; evaporating excess thionyl chloride from said mixture to form an evaporated mixture; and combining said evaporated mixture with guanidine to form a compound of formula Iâ€², wherein R1 is methylsulfonyl or hydrogen, R2 is hydrogen or a halogen, R3 is hydrogen, R4 is hydrogen or a halogen, or R3 and R4, together with the carbon atoms to which they are attached, form a six member fully unsaturated ring having one hetero atom that is nitrogen.