Patent ID: 7662972
Filing Date: 2010-02-16
Classification: A01N,A61K,A61P,C07C,C07D,C07F

Abstract:
1. An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A G is a benzene ring; W is an oxygen atom or sulfur atom; X is halogen atom, cyano, nitro, azido, —SCN, —SF further, when two Xs are adjacent, the adjacent two Xs may form 5-membered or 6-membered ring together with carbon atoms to which the two Xs are bonded by forming —CH 2 CH 2 CH 2 —, —CH 2 CH 2 O—, —CH 2 OCH 2 —, —OCH 2 O—, —CH 2 CH 2 S—, —CH 2 SCH 2 —, —CH 2 CH 2 N(R 15 )—, —CH 2 N(R 15 )CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 O—, —CH 2 CH 2 OCH 2 —, —CH 2 OCH 2 O—, —OCH 2 CH 2 O—, —OCH 2 CH 2 S—, —CH 2 CH═CH—, —OCH═CH—, —SCH═CH—, —N(R 15 )CH═CH—, —OCH═N—, —SCH═N—, —N(R 15 )CH═N—, —N(R 15 )N═CH—, —CH═CHCH═CH— or —OCH 2 CH═CH—, in this case, hydrogen atoms bonded to each carbon atom forming the ring may be arbitrarily substituted with Z, further when the hydrogen atoms are substituted with two or more Zs at the same time, each Z may be identical with or different from each other; Y is halogen atom, cyano, nitro, azido, —SCN, —SF further, when two Ys are adjacent, the adjacent two Ys may form 5-membered or 6-membered ring together with carbon atoms to which the two Ys are bonded by forming —CH 2 CH 2 CH 2 —, —CH 2 CH 2 O—, —CH 2 OCH 2 —, —OCH 2 O—, —CH 2 CH 2 S—, —CH 2 SCH 2 —, —SCH 2 S—, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 O—, —CH 2 CH 2 OCH 2 —, —CH 2 OCH 2 O—, —OCH 2 CH 2 O—, —OCH 2 CH 2 S—, —SCH 2 CH 2 S—, —OCH═N— or —SCH═N—, in this case, hydrogen atoms bonded to each carbon atom forming the ring may be arbitrarily substituted with Z, further when the hydrogen atoms are substituted with two or more Zs at the same time, each Z may be identical with or different from each other; R or R R 1a and R 2a together may form a 5- or 6-membered ring together with the carbon atom bonding them by forming C 4 -C 5 alkylene chain or C 4 -C 5 alkenylene chain, in this case, the alkylene chain and the alkenylene chain may contain one to three oxygen atoms or sulfur atoms, or R 1a and R 2a together may form a 5-membered ring together with the carbon atom bonding them by forming C 4 alkylene chain or C 4 alkenylene chain, in this case, the alkylene chain and the alkenylene chain may contain one to three nitrogen atoms, and either ring may be arbitrarily substituted with halogen atom, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio or C 1 -C 6 haloalkylthio; R D-1 to D-46, and D-61 to D-65 are aromatic heterocyclic rings of the following formulae, respectively Z is halogen atom, cyano, nitro, C further, when two Zs are adjacent, the adjacent two Zs may form 5-membered or 6-membered ring together with carbon atoms to which the two Zs are bonded by forming —CH 2 CH 2 CH 2 —, —CH 2 CH 2 O—, —CH 2 OCH 2 —, —OCH 2 O—, —CH 2 CH 2 S—, —CH 2 SCH 2 —, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 O—, —CH 2 CH 2 OCH 2 —, —CH 2 OCH 2 O—, —OCH 2 CH 2 O—, —CH 2 CH 2 CH 2 S—, —OCH 2 CH 2 S— or —CH═CH—CH═CH—, in this case, hydrogen atoms bonded to each carbon atom forming the ring may be arbitrarily substituted with halogen atom, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy or C 1 -C 4 alkylthio; E-1 to E-28, E-32 to E-38 and E-43 to E-45 are saturated heterocyclic rings of the following formulae, respectively R R R R R R R R R R R R M-1 to M-11 are partially saturated heterocyclic rings of the following formulae, respectively R R R R R R R R R R R R R R R R R R R R R R m is an integer of 0 to 5; n is an integer of 0 to 4; p1 is an integer of 1 to 5; p2 is an integer of 0 to 4; p3 is an integer of 0 to 3; p4 is an integer of 0 to 2; p5 is an integer of 0 or 1; q1 is an integer of 0 to 3; q2 is an integer of 0 to 5; q3 is an integer of 0 to 7; q4 is an integer of 0 to 9; r is an integer of 0 to 2; and t is an integer of 0 or 1.