Patent ID: 6924386
Filing Date: 2005-08-02
Classification: C07B,C07C,C07D

Abstract:
1. A process for preparing compounds of the general formula (1a) or (1b) where R R R X is selected from l is an integer having the value 0 or 1, W may be O or NR R R Y is CN, (C═O)—Z, (SO 2 )—Z, (P═O)(—Z) 2 or an aromatic radical where one or more methine units in the ring may be replaced by —N═ or —P═ groups and the ring may be of the heteroatoms —O—, —S— or —NH—, and where the aromatic ring is optionally halogen- or cyano-substituted or substituted by C 1 -C 30 -hydrocarbon radicals in which one or more, nonadjacent methylene units may be replaced by —O—, —CO—, —COO—, —OCO—, or —OCOO—, —S— or —NR x -groups, and Z is an optionally halogen-substituted C which comprises reacting aldehydes or imines of the general formula (2) at a temperature of less than 15° C. in the presence of a chiral, enantiomerically pure auxiliary having at least two nitrogen donors and at least one cyclic group, with the proviso that protons present have a pKa of greater than 18 with an organozinc halide which is obtained from zinc and a reactive halogen compound of the general formula (3) where Hal is chlorine, bromine or iodine, and subsequently adding water, acid or base, or a reagent selected from the group consisting of an alkylating reagent, an arylating reagent, an acylating reagent and a silylating reagent.