Patent ID: 6281193
Filing Date: 2001-08-28
Classification: A61K,A61P,C07K,C12N,C12Q,G01N,Y10S

Abstract:
A compound capable of disrupting the binding of Raf-1 protein and 14-3-3 to IL-2R.beta. and selected from the group consisting of a peptide having the amino acid sequence corresponding to residues 370 to 396 of SEQ ID NO:2, an analog of said peptide where one amino acid residue of residues 370 to 396 of SEQ ID NO:2 is replaced with a different amino acid residue or deleted, and a chemical derivative of said peptide which enhances the peptide's permeability across the cell membrane or facilitates the transport of the Peptide through the membrane into the cytoplasm, wherein said compound is not a full length human IL-2R.beta. chain.