Patent ID: 7507538
Filing Date: 2009-03-24
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method of inducing a cytotoxic T lymphocyte response against human papilloma virus 16 (HPV 16) in a patient, the method comprising contacting cytotoxic T cells from a patient with an immunogenic peptide of 20 amino acid residues or less comprising a cross-reactive peptide from the E6 protein of a related HPV strain, HPV 18, that has higher affinity for the HLA-A2.1 molecule than the corresponding epitope from HPV 16 itself, said peptide comprising the sequence X 1 KLPDLCTEL(SEQ ID NO:1)X 2 , wherein X 1 and X 2 are peptides of 0-11 amino acids in length consisting of contiguous HPV 18 E6 amino acids, and returning said cytotoxic T cells to the patient in an amount sufficient to induce a cytotoxic T cell response.