Patent ID: 8013042
Filing Date: 2011-09-06
Classification: A61K,A61Q,C08J,Y10T

Abstract:
1. A process for producing a particle having a core-shell structure and comprising an organic solid component (A) containing a thermoplastic polymer (A1) and a thermoplastic hydrophilic polymer (A2), which comprises kneading the organic solid component (A) with a water-soluble auxiliary component (B) containing at least an oligosaccharide (B1) to provide a composition which has a disperse system and comprises a matrix comprising the water-soluble auxiliary component (B) and a particulate dispersed phase comprising the organic solid component (A) and dispersed in the matrix, wherein the particulate dispersed phase corresponds to the particle having a core-shell structure, and eluting the auxiliary component (B) from the composition; and wherein the core of the particle contains the polymer (A1) and the shell of the particle contains the hydrophilic polymer (A2) which has a hydrophilicity higher than the polymer (A1), wherein the particle is spherical and has an average particle size of 0.1 to 100 μm, a coefficient of variation of the average particle size of not more than 60.