Patent ID: 6958330
Filing Date: 2005-10-25
Classification: C07D

Abstract:
1. A compound of formula I: wherein W is a substituted ε-caprolactam selected from the group consisting of: wherein ring A, together with the atoms of the ε-caprolactam to which it is attached, forms a carbocyclic or heterocyclic ring selected from the group consisting of: A) aryl having from 6 to 14 ring carbon atoms substituted with from 1 to 5 substituents selected from the group consisting of: B) cycloalkyl of from 3 to 12 carbon atoms; C) substituted cycloalkyl having 3 to 12 carbon atoms and from 1 to 5 substituents selected from the group consisting of: D) cycloalkenyl of from 4 to 8 carbon atoms; E) substituted cycloalkenyl having from 4 to 8 carbon atoms and from 1 to 5 substituents selected from the group consisting of: F) heteroaryl of from 1 to 15 ring carbon atoms and 1 to 4 ring heteroatoms selected from oxygen, nitrogen and sulfur, substituted with from 1 to 5 substituents selected from: G) heterocyclic of from 1 to 15 ring carbon atoms and from 1 to 4 ring atoms selected from nitrogen, sulfur and oxygen, substituted with from 1 to 5 substituents selected from: ring B, together with the atoms of the ε-caprolactam to which it is attached, forms a carbocyclic or heterocyclic ring selected from the group consisting of: H) aryl as defined in A herein; I) cycloalkyl as defined in B herein; J) substituted cycloalkyl as defined in C herein; K) cycloalkenyl as defined in D herein; L) substituted cycloalkenyl as defined in E herein; M) heteroaryl as defined in F herein; and N) heterocyclic as defined in G herein; ring C, together with the atoms of the ε-caprolactam to which it is attached, forms a heteroaryl as defined in F herein or heterocyclic ring as defined in G herein; R O) hydrogen; and P) an amino-blocking group being any group, bound to an amino group, which prevents undesired reactions from occurring at the amino group and which may be removed by conventional chemical and/or enzymatic procedures to reestablish the amino group; R Q) hydrogen; R) alkyl of from 1 to 20 carbon atoms; S) substituted alkyl of from 1 to 20 carbon atoms, having from 1 to 5 substituents selected from: T) alkenyl of from 2 to 10 carbon atoms and 1-2 sites of alkenyl unsaturation; U) substituted alkenyl having from 1 to 3 substituents selected from the group consisting of: V) alkynyl of from 2 to 10 carbon atoms and from 1-2 sites of alkynyl unsaturation; W) substituted alkynyl of from 1 to 3 substituents selected from: X) aryl as defined in A herein; Y) cycloalkyl as defined in B herein; Z) heteroaryl as defined in F herein; and AA) heterocyclic as defined in G herein; R BB) hydrogen; CC) alkyl as defined in R herein; DD) substituted alkyl as defined in S herein; EE) alkenyl as defined in T herein; FF) substituted alkenyl as defined in U herein; GG) alkynyl as defined in as defined in V herein; HH) substituted alkynyl as defined in W herein; II) acyl as defined in A3 herein; JJ) aryl as defined in A herein; KK) cycloalkyl as defined in B herein; LL) substituted cycloalkyl as defined in C herein; MM) cycloalkenyl as defined in D herein; NN) substituted cycloalkenyl as defined in E herein; OO) heteroaryl as defined in F herein; and PP) heterocyclic as defined in G herein; each R QQ) alkyl as defined in R herein; RR) substituted alkyl as defined in S herein; SS) alkenyl as defined in T herein; TT) substituted alkenyl as defined in U herein; UU) alkynyl as defined in V herein; VV) substituted alkynyl as defined in W herein; WW) aryl as defined in A herein; XX) cycloalkyl as defined in B herein; YY) substituted cycloalkyl as defined in C herein; ZZ) cycloalkenyl as defined in D herein; AAA) substituted cycloalkenyl as defined in E herein; BBB) heteroaryl as defined in F herein; and CCC) heterocyclic as defined in G herein; m is an integer from 0 to 2; or salts thereof.