Patent ID: 6794137
Filing Date: 2004-09-21
Classification: A61P,C12Q,G01N

Abstract:
A method for detecting exposure of a cell to ultraviolet radiation, comprising measuring the levels of a plurality of RNA molecules in the cell for at least one time point after ultraviolet radiation exposure to establish a pattern of expression, the response of the cell to ultraviolet radiation exposure comprising at least one of the following:(a) a first response comprising altered expression of at least one nucleic acid molecule encoding a transcription factor protein, at least one nucleic acid molecule encoding a signal transducing protein, and at least one nucleic acid molecule encoding a mitochondrial protein; (b) a second response comprising altered expression of at least one nucleic acid molecule encoding a secreted growth factor, at least one nucleic acid molecule encoding a cytokine, and at least one nucleic acid molecule encoding a chemokine; and (c) a third response comprising altered expression of at least one nucleic acid molecule encoding an actin-binding protein, at least one nucleic acid molecule encoding a desmosomal protein, and at least one nucleic acid molecule encoding a tubulin protein; and wherein if the pattern of expression for the cell is substantially similar to the response of the cell to ultraviolet radiation, the cell was exposed to ultraviolet radiation.