Patent ID: 8946172
Filing Date: 2015-02-03
Classification: A61P,C12N

Abstract:
1. A method for reducing hypertrophic scarring resulting from dermal wound healing in a subject in need thereof which comprises administering directly to the subject's wound an antisense compound which targets a nucleic acid encoding, and inhibits expression of, connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring, wherein the antisense compound comprises an antisense oligonucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2, wherein the antisense compound is to be administered intermittently with each subsequent administration being effected at least 4 days after the prior administration and wherein the antisense compound is administered in an amount effective to reduce scarring without having an adverse effect on wound healing.