Patent ID: 6846833
Filing Date: 2005-01-25
Classification: A61P,C07D

Abstract:
1. A compound selected from those of formula (I): t, 0250 wherein: G represents a phenyl unsubstituted or substituted by R G —T R R R R —W— represents —CH—, ═C— or —C═ and —A— represents —CH —X— represents a group selected from —CO—X —Y — represents a group selected from —Y Z— represents a group selected from Z Z m is an integer of from 1 to 6 inclusive, wherein: “alkyl” is a linear or branched, 1 to 6 carbon alkyl group, “heteroalkyl” is an alkyl in which a carbon atom has been replaced by a hetero atom selected from nitrogen, oxygen and sulphur, “alkylene” is a linear or branched divalent 1 to 6 carbon group, “alkenylene” is a linear or branched divalent 2 to 6 carbon group with 1 to 3 double bonds, “alkynylene” is a linear or branched divalent 2 to 6 carbon group with 1 to 3 triple bonds, “cycloalkyl” is a saturated 3 to 8 carbon cyclic group, “cycloalkylene” is a saturated 3 to 8 carbon cyclic divalent group, “heterocycloalkyl” is a saturated cyclic 5 to 7 ring membered group with 1 to 3 hetero atoms selected from nitrogen, oxygen and sulphur, “aryl” is a phenyl or naphthyl, “heteroaryl” is an unsaturated or partially unsaturated mono- or bi-cyclic 5 to 11 membered group with 1 to 5 hereto atoms selected from nitrogen, oxygen and sulphur, “fused arylheteroaryl” is a polycyclic group formed by an aryl and a heteroaryl, each as defined hereinabove, and conjoined by means of any one of their bonds, “fused arylheterocycloalkyl” is a bi- or tri-cyclic group formed by an aryl and a heterocycloalkyl, each as defined hereinabove, and conjoined by means of any one of their bonds, “fused heteroarylheterocycloalkyl” is a bi- or tri-cyclic group formed by a heteroaryl and a heterocycloalkyl, each as defined hereinabove, and conjoined by means of any one of their bonds, “fused heterocycloalkylheteroaryl” is a bi- or tri-cyclic group formed by a heteroaryl and a heterocycloalkyl, each as defined hereinabove, and conjoined by means of any one of their bonds, “fused heteroarylheteroaryl” is a polycyclic group formed by two heteroaryl groups, as defined hereinabove, and conjoined by means of any one of their bonds, “fused cycloalkylheterocycloalkyl” is a bicyclic group formed by a cycloalkyl and a heterocycloalkyl, each as defined hereinabove, and conjoined by means of any one of their bonds, the ending “-ene” is that the group in question is a divalent radical having the same meanings as the base radical, the expression “optionally substituted” in connection with the groups heterocycloalkyl, aryl, arylalkyl, heteroaryl, fused arylheteroaryl, fused heteroarylheterocycloalkyl, fused heteroarylheteroaryl and fused arylheterocycloalkyl is that those groups are unsubstituted or substituted by one or more atoms or groups selected from alkyl, alkoxy, hydroxy mercapto, cyano, amino (optionally substituted by one or two alkyl), nitro, carboxy, alkoxycarbonyl, aminocarbonyl (optionally substituted by one or two alkyl), wherein the heteroaryl and heterocycloalkyl groups may also be substituted by an oxo, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.