Patent ID: 6498168
Filing Date: 2002-12-24
Classification: A61P,C07C,C07D

Abstract:
A compound having the structural formula or an isomer or pharmaceutically acceptable salt or solvate thereof,wherein one ofY and Z is N and the other is CH, or C-alkyl; X is â€”Oâ€”, â€”Sâ€”, â€”SOâ€” or â€”SO2â€”; R is pyridyl; R1 and R21 are independently selected from the group consisting of alkyl, cyano, H or â€”OH, (provided R1 and R21 are both not â€”OH and Y is not N); additionally R1 and R21 together may form the group &boxH;CH2, &boxH;CH-alkyl, &boxH;O or &boxH;C(alkyl)2; R2 is cycloalkyl; R3and R4 are H; and R27 and R28 are independently selected from the group consisting of H and alkyl.