Patent ID: 6346404
Filing Date: 2002-02-12
Classification: C07K,C12P

Abstract:
An isolated nucleic acid fragment comprising a nucleotide sequence that encodes at least one polypeptide required for the biosynthesis of epothilone, wherein the complement of said nucleotide sequence hybridizes to a sequence selected from the group consisting of: nucleotides 7610-11875 of SEQ ID NO:1, nucleotides 7643-8920 of SEQ ID NO:1, nucleotides 9236-10201 of SEQ ID NO:1, nucleotides 10529-11428 of SEQ ID NO:1, and nucleotides 11549-11764 of SEQ ID NO:1, under conditions of hybridization at 65Â° C. for 36 hours and washing 3 times at high stringency with 0.1Ã—SSC and 0.5% SDS for 20 minutes at 65Â° C.