Patent ID: 6764996
Filing Date: 2004-07-20
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of compounds of formula (I) compounds of formula (II) compounds of formula (III) andcompounds of formula (IV) or pharmaceutically acceptable salts thereof, wherein, in formulas (I)-(IV), R1 is selected from the group consisting of(1) â€”C3-C12-alkenyl, and (2) â€”C3-C12-alkynyl, wherein (1)-(2) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of(a) halogen, (b) â€”OR9, wherein R9 is selected from the group consisting of (i) hydrogen, (ii) â€”C1-C12-alkyl, (iii) â€”C2-C12-heteroalkyl, wherein (ii) and (iii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iv) aryl, (v) substituted aryl, (vi) heteroaryl, and (xv) substituted heteroaryl, (c) â€”NR11R12, wherein R11 and R12 are independently selected from the group consisting of (i) hydrogen, (ii) â€”C1-C12-alkyl, (iii) â€”C2-C12-heteroalkyl, wherein (ii) and (iii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iv) aryl, (v) substituted aryl, (vi) heteroaryl, and (xv) substituted heteroaryl, or R11 and R12, together with the atom to which they are attached, form a heterocycloalkyl ring, wherein the heterocycloalkyl ring can be optionally substituted, (d) &boxH;Nâ€”Oâ€”R9, wherein R9 is defined above, (e) aryl, (f) substituted aryl, (g) heteroaryl, (h) substituted heteroaryl, (i) â€”C3-C8-cycloalkyl, (j) heterocycloalkyl, (k) substituted heterocycloalkyl, (l) â€”NHC(O)R9, wherein R9 is defined above, (m) â€”NHC(O)OR10, wherein R10 is selected from the group consisting of (i) â€”C1-C12-alkyl, (ii) â€”C1-C12-heteroalkyl, wherein (i) and (ii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iii) aryl, (iv) substituted aryl, (v) heteroaryl, and (vi) substituted heteroaryl, (n) â€”NHC(O)NR11R12, wherein R11 and R12 are defined above, (o) â€”OC(O)R10, wherein R10 is defined above, (p) â€”OC(O)OR10, wherein R10 is defined above, (q) â€”OC(O)NR11R12, where in R11 and R12 are defined above, (s) â€”CO2R9, wherein R9 is defined above, and (t) â€”C(O)NR11R12, wherein R11 and R12 are defined above; R2 is hydrogen; R3 is â€”OR13, wherein R13 is selected from the group consisting of (1) hydrogen, (2) â€”C(O)R10, wherein R10 is defined above, (3) â€”CO2R10, wherein R10 is defined above, and (4) â€”C(O)NR11R12, wherein R11 and R12 are defined above; or R2 and R3 together are oxo; R4 and R5 are hydrogen; or R4 and R5 together are â€”C(O)â€” or â€”CH2)xâ€”, wherein x is one, two, or three; or R5 and R6 together are â€”C(O)â€” or â€”CH2)xâ€”, wherein x is defined above; R6 is selected from the group consisting of (1) hydrogen, (2) â€”C1-C12-alkyl, (3) (1) â€”C3-C12-alkenyl, and (4) (2) â€”C3-C12-alkynyl, wherein (1)-(4) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (a) halogen, (b) â€”OR9, wherein R9 is selected from the group consisting of (i) hydrogen, (ii) â€”C1-12-alkyl, (iii) â€”C2-C12-heteroalkyl, wherein (ii) and (iii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iv) aryl, (v) substituted aryl, (vi) heteroaryl, and (xv) substituted heteroaryl, (c) â€”NR11R12, wherein R11 and R12 are independently selected from the group consisting of (i) hydrogen, (ii) â€”C1-12-alkyl, (iii) â€”C2-C12-heteroalkyl, wherein (ii) and (iii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iv) aryl, (v) substituted aryl, (vi) heteroaryl, and (xv) substituted heteroaryl, or R11 and R12, together with the atom to which they are attached, form a heterocycloalkyl ring, wherein the heterocycloalkyl ring can be optionally substituted, (d) &boxH;Nâ€”Oâ€”R9, wherein R9 is defined above, (e) aryl, (f) substituted aryl, (g) heteroaryl, (h) substituted heteroaryl, (i) â€”C3-C8-cycloalkyl, (j) heterocycloalkyl, (k) substituted heterocycloalkyl, (l) â€”NHC(O)R9, wherein R9 is defined above, (m) â€”NHC(O)OR10, wherein R10 is selected from the group consisting of (i) â€”C1-C12-alkyl, (ii) â€”C1-C12-heteroalkyl, wherein (i) and (ii) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (1â€²) aryl, (2â€²) substituted aryl, (3â€²) heteroaryl, and (4â€²) substituted heteroaryl, (iii) aryl, (iv) substituted aryl, (v) heteroaryl, and (vi) substituted heteroaryl (n) â€”NHC(O)NR11R12, wherein R11 and R12 are defined above, (o) â€”OC(O)R10, wherein R10 is defined above, (p) â€”OC(O)OR10, wherein R10 is defined above, (q) â€”OC(O)NR11R12, wherein R11 and R12 are defined above, (r) â€”C(O)R9, wherein R9 is defined above, (s) â€”CO2R9, wherein R9 is defined above, and (t) â€”C(O)NR11R12, wherein R11 and R12 are defined above; R7 is selected from the group consisting of (1) hydrogen, (2) â€”C1-C12-alkyl, (3) â€”C3-C12-alkenyl, (4) â€”C3-C12-alkynyl, (5) â€”C2-C12-heteroalkyl, (6) â€”C4-C12-heteroalkenyl, (7) â€”C4-C12-heteroalkynyl, wherein (2)-(7) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (a) halo, (b) hydroxy, (c) â€”NR11R12, wherein R11 and R12 are defined above, (d) aryl, (e) substituted aryl, (f) heteroaryl, and (g) substituted heteroaryl, (8) â€”C(O)R9, wherein R9 is defined above, (9) â€”CO2R9, wherein R9 is defined above, and (11) â€”C(O)NR11R12, wherein R11 and R12 are defined above; and R8 is hydrogen or a hydroxy protecting group; wherein substituted aryl is an aryl group substituted by independent replacement of one, two, or three of the hydrogen atoms thereon with â€”F, â€”Cl, â€”Br, â€”I, â€”OH, â€”NO2, â€”CN, â€”C(O)â€”C1-C6-alkyl, â€”C(O)-aryl, â€”C(O)-heteroaryl, â€”CO2-alkyl, â€”CO2-aryl, â€”CO2-heteroaryl, â€”CONH2, â€”CONHâ€”C1-C6-alkyl, â€”CONH-aryl, â€”CONH-heteroaryl, â€”OC(O)â€”C1-C6-alkyl, â€”OC(O)-aryl, â€”OC(O)-heteroaryl, â€”OCO2-alkyl, â€”OCO2-aryl, â€”OCO2-heteroaryl, â€”OCONH2, â€”OCONHâ€”C1-C6-alkyl, â€”OCONH-aryl, â€”OCONH-heteroaryl, â€”NHC(O)â€”C1-C6-alkyl, â€”NHC(O)-aryl, â€”NHC(O)-heteroaryl, â€”NHCO2-alkyl, â€”NHCO2-aryl, â€”NHCO2-heteroaryl, â€”NHCONH2, â€”NHCONHâ€”C1-C6-alkyl, â€”NHCONH-aryl, â€”NHCONH-heteroaryl, â€”SO2â€”C1-C6-alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, â€”SO2NH2, â€”SO2NHâ€”C1-C6-alkyl, â€”SO2NH-aryl, â€”SO2NH-heteroaryl, â€”C1-C6-alkyl, â€”C3-C6-cycloalkyl, â€”CF3, â€”CH2CF3, â€”CHCl2, â€”CH2OH, â€”CH2CH2OH, â€”CH2NH2, â€”CH2SO2CH3, aryl, heteroaryl, benzyl, benzyloxy, aryloxy, heteroaryloxy, â€”C1-C6-alkoxy, methoxymethoxy, methoxyethoxy, amino, benzylamino, arylamino, heteroarylamino, â€”C1-C3-alkylamino, arylthio, heteroarylthio, benzylthio, â€”C1-C6-alkylthio, or methylthiomethyl; substituted heteroaryl is a heteroaryl group substituted by independent replacement of one, two or three of the hydrogen atoms thereon with â€”F, â€”Cl, â€”Br, â€”I, â€”OH, â€”NO2, â€”CN, â€”C(O)â€”C1-C6-alkyl, â€”C(O)-aryl, â€”C(O)-heteroaryl, â€”CO2-alkyl, â€”CO2-aryl, â€”CO2-heteroaryl, â€”CONH2, â€”CONHâ€”C1-C6-alkyl, â€”CONH-aryl, â€”CONH-heteroaryl, â€”OC(O)â€”C1-C6-alkyl, â€”OC(O)-aryl, â€”OC(O)-heteroaryl, â€”OCO2-alkyl, â€”OCO2-aryl, â€”OCO2-heteroaryl, â€”OCONH2, â€”OCONHâ€”C1-C6-alkyl, â€”OCONH-aryl, â€”OCONH-heteroaryl, â€”NHC(O)â€”C1-C6-alkyl, â€”NHC(O)-aryl, â€”NHC(O)-heteroaryl, â€”NHCO2-alkyl, â€”NHCO2-aryl, â€”NHCO2-heteroaryl, â€”NHCONH2, â€”NHCONHâ€”C1-C6-alkyl, â€”NHCONH-aryl, â€”NHCONH-heteroaryl, â€”SO2â€”C1-C6-alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, â€”SO2NH2, â€”SO2NHâ€”C1-C6-alkyl, â€”SO2NH-aryl, â€”SO2NH-heteroaryl, â€”C1-C6-alkyl, â€”C3-C6-cycloalkyl, â€”CF3, â€”CH2CF3, â€”CHCl2, â€”CH2OH, â€”CH2CH2OH, â€”CH2NH2, â€”CH2SO2CH3, aryl, heteroaryl, benzyl, benzyloxy, aryloxy, heteroaryloxy, â€”C1-C6-alkoxy, methoxymethoxy, methoxyethoxy, amino, benzylamino, arylamino, heteroarylamino, â€”C1-C3-alkylamino, arylthio, heteroarylthio, benzylthio, â€”C1-C6-alkylthio, or methylthiomethyl; and substituted heterocycloalkyl is a heterocycloalkyl group substituted by independent replacement of one, two or three of the hydrogen atoms thereon with â€”F, â€”Cl, â€”Br, â€”I, â€”OH, â€”NO2, â€”CN, â€”C(O)â€”C1-C6-alkyl, â€”C(O)-aryl, â€”C(O)-heteroaryl, â€”CO2-alkyl, â€”CO2-aryl, â€”CO2-heteroaryl, â€”CONH2, â€”CONHâ€”C1-C6-alkyl, â€”CONH-aryl, â€”CONH-heteroaryl, â€”OC(O)â€”C1-C6-alkyl, â€”OC(O)-aryl, â€”OC(O)-heteroaryl, â€”OCO2-alkyl, â€”OCO2-aryl, â€”OCO2-heteroaryl, â€”OCONH2, â€”OCONHâ€”C1-C6-alkyl, â€”OCONH-aryl, â€”OCONH-heteroaryl, â€”NHC(O)â€”C1-C6-alkyl, â€”NHC(O)-aryl, â€”NHC(O)-heteroaryl, â€”NHCO2-alkyl, â€”NHCO2-aryl, â€”NHCO2-heteroaryl, â€”NHCONH2, â€”NHCONHâ€”C1-C6-alkyl, â€”NHCONH-aryl, â€”NHCONH-heteroaryl, â€”SO2â€”C1-C6-alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, â€”SO2NH2, â€”SO2NHâ€”C1-C6-alkyl, â€”SO2NH-aryl, â€”SO2NH-heteroaryl, â€”C1-C6-alkyl, â€”C3-C6-cycloalkyl, â€”CF3, â€”CH2CF3, â€”CHCl2, â€”CH2OH, â€”CH2CH2OH2, â€”CH2NH2, â€”CH2SO2CH3, aryl, heteroaryl, benzyl, benzyloxy, aryloxy, heteroaryloxy, alkoxy, methoxymethoxy, methoxyethoxy, amino, benzylamino, arylamino, heteroarylamino, â€”C1-C3-alkylamino, arylthio, heteroarylthio, benzylthio, alkylthio, or methylthiomethyl.