Patent ID: 6258784
Filing Date: 2001-07-10
Classification: C07H

Abstract:
A compound of formula I having the structure ##STR19##whereinW is S, SO, SO.sub.2, NR;Y is O, S, NR, or CH.sub.2 ;R is hydrogen or alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms;R.sup.1 and R.sup.7 are each, independently, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, haloalkyl of 1-6 carbon atoms, nitroalkyl of 1-6 carbon atoms, cyanoalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, nitriloalkyl of 1-6 carbon atoms, phenyl mono-, di-, or tri-substituted with R.sup.8, phenylalkyl of 7-10 carbon atoms, wherein the phenyl ring is mono-, di-, or tri-substituted with R.sup.8, pyridyl substituted with R.sup.8, furyl substituted with R.sup.8, thienyl substituted with R.sup.8, and thiazolyl substituted with R.sup.8 ;R.sup.2 is hydrogen, ##STR20##R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are each, independently, hydrogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, benzyl, wherein the phenyl moiety is mono-, di-, or tri-substituted with R.sup.8, benzoyl, wherein the phenyl moiety is mono-, di-, or tri-substituted with R.sup.8 ;R.sup.8 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, --CN, --NO.sub.2, halogen, or --CF.sub.3 ;R.sup.9 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, --CN, --NO.sub.2, halogen, --NHCO.sub.2 R.sup.13, --NHSO.sub.2 R.sup.13, --NR.sup.14 R.sup.15, ##STR21##R.sup.10, R.sup.11, and R.sup.12, are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, --CN, --NO.sub.2, halogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms, or benzoyl, wherein the phenyl moiety of the benzoyl group is optionally mono-, di-, or tri-substituted with alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, --CN, --NO.sub.2, halogen, or --CF.sub.3 ;R.sup.13 is alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, phenyl or phenyl substituted with halogen;R.sup.14 and R.sup.15 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms;n=0-3;or a pharmaceutically acceptable salt thereof.