Patent ID: 7314855
Filing Date: 2008-01-01
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting growth of a tumor cell, which method comprises inhibiting transcriptional activity of ATF2 by contacting the cell with an inhibitory N-terminal fragment of ATF2, wherein the inhibitory N-terminal fragment of ATF2 is selected from the group consisting of: i. a peptide consisting of amino acid residues 1 to 115 of ATF-2; ii. a peptide consisting of amino acid residues 50 to 100 of ATF-2; iii. a peptide consisting of amino acid residues 45 to 75 of ATF-2; iv. a peptide consisting of amino acid residues 45 to 100 of ATF-2; and v. a peptide consisting of amino acid residues 50 to 75 of ATF-2.