Patent ID: 6441020
Filing Date: 2002-08-27
Classification: C07D,C07F

Abstract:
A compound of the formula:PIâ€”Oâ€”Gx wherein PI is a moiety of the formula: â€ƒin the form of an individual isomer, an isomer mixture, a racemate or optical antipode, or a pharmaceutically acceptable salt thereof; wherein K1 represents 1-3 substituents located independently at any of carbons 5, 6 and 7, which substituents are selected from the group consisting of hydrogen, halogen and a straight chain or branched chain, cyclic or acyclic, saturated or unsaturated or aromatic carbon- and/or heteroatom-containing moiety which moieties, taken together, contain not more than 40 carbon atoms, not more than 24 halogen atoms and not more than 9 heteroatoms selected from the group consisting of oxygen, nitrogen, silicon, phosphorus, and sulfur, the moieties being optionally connected to one another, to K3 and/or to K2 to form 1-3 additional carbocyclic or heterocyclic rings; wherein K2 is a straight chain or branched chain, cyclic or acyclic, saturated or unsaturated or aromatic carbon- and/or heteroatom-containing moiety which is bound to N1 via a carbon atom of the moiety and which contains 1-40 carbon atoms, not more than 20 halogen atoms and not more than 8 heteroatoms selected from the group consisting of oxygen, nitrogen, silicon, phosphorus and sulfur, said moiety being optionally connected to K1 to form an additional carbocyclic or heterocyclic ring; wherein K3 is hydrogen or a straight chain or branched chain, cyclic or acyclic, saturated or unsaturated or aromatic carbon- and/or heteroatom-containing moiety containing not more than 30 carbon atoms, not more than 24 halogen atoms and not more than 8 heteroatoms selected from the group consisting of oxygen, nitrogen, silicon, phosphorus and sulfur, said moiety being optionally connected to either K4 or K1 to form an additional ring; wherein K4 is hydrogen or a straight chain or branched chain, cyclic or acyclic, saturated or unsaturated or aromatic carbon- and/or heteroatom-containing moiety containing not more than 20 carbon atoms, not more than 24 halogen atoms and not more than 9 heteroatoms selected from the group consisting of oxygen, nitrogen, silicon, phosphorus and sulfur, said moiety being optionally connected to K3 to form an additional ring; and wherein Gx is bound to the oxygen atom attached to carbon 14 of PI and comprises a moiety selected from the group consisting of substituted or unsubstituted, straight or branched, acyclic or cyclic alkyls, alkenyls, alkynyls, aryls and aralkyls containing not more than 30 carbon atoms, not more than 15 halogen atoms and not more than 8 heteroatoms selected from the group consisting of oxygen, nitrogen, silicon, phosphorus and sulfur; provided that carbon 14 of PI, the oxygen atom and the carbon atom of Gx which is attached to 14-O form an ether linkage; and provided that PIâ€”Oâ€”Gx may not be N1,14-O-dimethyl-(9S,12S)-indolactam V.