Patent ID: 7767402
Filing Date: 2010-08-03
Classification: A61K,G06Q

Abstract:
1. A screening assay method for identifying a compound that decreases insulin resistance or increases insulin sensitivity, comprising providing a cell-free composition that comprises a polypeptide which is an endoplasmic reticulum stress response pathway molecule; contacting the cell-free composition with a test compound; and determining an effect of the test compound on an activity of the polypeptide in the composition, wherein an increase in the activity of the polypeptide in the presence of the compound, relative to a suitable control, identifies the compound as one that decreases insulin resistance or increases insulin sensitivity wherein the polypeptide is selected from the group consisting of BiP, ERO-1, CHOP and XBP-1 and wherein said polypeptide has an effect on regulating glucose uptake which is in an insulin-dependent manner in the adipocyte or preadipocyte during adipogenesis.