Patent ID: 7105513
Filing Date: 2006-09-12
Classification: C07D

Abstract:
1. A compound of the formula I, wherein: the ring A, which comprises the two carbon atoms common to the ring A and the cycloalkenyl ring in formula I, is an aromatic 5-membered or 6-membered ring containing 1 or 2 nitrogen atoms as ring heteroatoms, or ring A is an aromatic 5-membered ring containing 1 ring heteroatom which is an oxygen atom or a sulfur atom or containing 2 ring heteroatoms one of which is a nitrogen atom and the other of which is an oxygen atom or a sulfur atom; R H; unsubstituted or substituted C unsubstituted or substituted phenyl or heteroaryl the substituents of which are selected from the group consisting of halogen, —CN, C COR NO provided that, when R R H; halogen; unsubstituted or substituted C OH; C unsubstituted or substituted phenyl-CONH— or unsubstituted or substituted phenyl-SO C unsubstituted or substituted (C phenyl-CO— the phenyl part of which is unsubstituted or substituted by substituents selected from the group consisting of C provided that, when R provided that, when A is a 6-membered aromatic ring, then two or three of the groups R R halogen; —CN; NH unsubstituted or substituted C C a residue of a saturated or at least monounsaturated aliphatic, monocyclic 5-membered to 7-membered heterocycle containing 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S, which heterocycle can be substituted by one or more substituents selected from the group consisting of halogen, C wherein all aryl, heteroaryl, phenyl, aryl-containing, heteroaryl-containing and phenyl-containing groups, which are optionally present in the said substituents of the said group Ar or the said group Hetar, can be substituted by one or more substituents selected from the group consisting of halogen, —CN, C R H; C aryl-(C R H; C phenyl; indanyl; or heteroaryl; wherein each of the aromatic groups can be unsubstituted or carry one or more substituents selected from the group consisting of halogen, —CN, C R R C unsubstituted or substituted phenyl or unsubstituted or substituted heteroaryl the substituents of each of which are selected from the group consisting of C R R R R H; C unsubstituted or substituted phenyl, unsubstituted or substituted benzyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted (C R R H; C R C CF substituted or unsubstituted phenyl or substituted or unsubstituted heteroaryl, the substituents of which are selected from the group consisting of halogen, —CN, C R R R R R R R R R R R heteroaryl is a residue of a 5-membered to 10-membered, aromatic, monocyclic or bicyclic heterocycle containing one or more heteroatoms selected from the group consisting of N, O and S; the group Hetar is a residue of a 5-membered to 10-membered, aromatic, monocyclic or bicyclic heterocycle containing one or more heteroatoms selected from the group consisting of N, O and S; aryl is phenyl, naphth-1-yl or naphth-2-yl; the group Ar is phenyl, naphth-1-yl or naphth-2-yl; m is 0, 1 or 2; n is 1, 2 or 3; or a stereoisomer or a mixture of stereoisomers of such compound in any ratio, or a pharmaceutically acceptable salt of such compound, stereoisomer or mixture; provided that when the compound of the formula I is the compound of the formula then R 50 is other than hydrogen, unsubstituted C 1 –C 6 -alkyl, C 1 –C 6 -alkoxy, unsubstituted C 1 –C 6 -alkylthio, halogen, —CN, CF 3 , OH, amino, C 1 –C 6 -alkylamino or di(C 1 –C 6 -alkyl)amino; and provided that when the compound of formula I is the compound of the formula then R 51 , R 52 , R 53 and R 54 are other than hydrogen, unsubstituted or hydroxy-substituted C 1 –C 6 -alkyl, halogen, amino, C 1 –C 6 -alkylamino or di(C 1 –C 6 -alkyl)amino and R 55 is other than unsubstituted or substituted phenyl, thienyl, furyl, pyrrolyl or oxazolyl; and provided that the compound of formula I is other than N-(2-amino-5,6,7,8-tetrahydro-4-hydroxyquinazolin-6-yl)-3,4-dichlorobenzamide.