Patent ID: 6063921
Filing Date: 2000-05-16
Classification: C07C,C07D

Abstract:
A method of preparing an 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepine represented by the following structural formula: ##STR8## wherein: Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents, wherein each substituent is independently chosen; andR is --H, an aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, --C(O)--R', --C(O)--H, --C(O)--NHR', --S(O).sub.2 R', --C(O)--C(O)--R', C(O)--C(O)--OH, --C(S)--R', --C(S)--H, --C(O)--OR', --C(S)--OR', --C(O)--SR', --C(S)--SR', --C(O)--NR'.sub.2 or --C(O)--C(S)--R', wherein R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group;said method comprising the steps of:a) reacting a base, a substituted 2-aminobenzophenone represented by the following structural formula: ##STR9## and a starting material represented by the following structural formula: ##STR10## wherein R.sub.1 is a leaving group, to form a diphenyl ketone represented by the following structural formula: ##STR11## b) reacting the diphenyl ketone formed in step a) with a ketone reducing agent to form an intermediate represented by the following structural formula: ##STR12## c) reacting the intermediate formed in step b) with one or more Lewis acids to form the 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepine.