Patent ID: 9012477
Filing Date: 2015-04-21
Classification: A61K,A61P

Abstract:
1. A method of treating neuropathic pain in a subject, comprising: applying a layer of a solid-forming local anesthetic formulation to a skin surface of a human experiencing neuropathic pain, said solid-forming local anesthetic formulation comprising a local anesthetic agent, water, and at least one polymer selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, ethylcellulose, or combinations thereof, and being in the state of a semi-solid before being applied to said skin surface; and maintaining said layer of said formulation on said skin surface for a period of time sufficient to allow said layer of said formulation to transdermally deliver the local anesthetic to the subject and to form a layer of a coherent soft solid after a sufficient amount of water is evaporated from said layer of said formulation, wherein the solid-forming local anesthetic formulation is formulated to deliver the local anesthetic agent to the subject until substantially all of the water present in the formulation has evaporated and delivery of the local anesthetic stops or slows significantly so as to have no therapeutic effect thereafter, and wherein the solid-forming local anesthetic formulation provides relief from said neuropathic pain within about 45 minutes after application to the skin surface.