Patent ID: 8524892
Filing Date: 2013-09-03
Classification: C07D

Abstract:
1. A method of making a compound of Formula II: wherein: R R R A is selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, alkoxy, halo, mercapto, azido, cyano, hydroxyl, nitro, acyl, alkoxy, alkylthio, amino, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, amide, sulfonamide, urea, alkoxylacylamino, aminoacyloxy, hydrophilic groups, surface attachment groups, cross-coupling groups and bioconjugatable groups; said method comprising: reacting a dipyrromethane of Formula IV: wherein A, R 2 , R 3 , R 4 and R 5 are as given above with an N,N-dialkylmethylammonium halide of Formula V: wherein R a , R b and R 1 are as given above, and X is halo; in a polar or nonpolar aprotic solvent selected from the group consisting of methylene chloride, chloroform, tetrahydrofuran, nitromethane, toluene, acetonitrile, and mixtures thereof at a temperature of from room temperature to 100° C. to produce said compound of Formula II.