Patent ID: 8212026
Filing Date: 2012-07-03
Classification: A61P,C07D

Abstract:
1. A process for the preparation of highly pure amorphous ivabradine hydrochloride of formula I, comprising the steps of: a. condensing methylamine of formula II, with 7,8-dimethoxy-3-[3-iodopropyl]-1,3-dihydro-2H-3-benzazepin-2-one of formula III in the presence of a base in polar solvent to prepare benzazepine intermediate of formula IV; b. hydrogenating the benzazepine intermediate of formula IV with palladium on carbon in glacial acetic acid under an atmosphere of hydrogen to get ivabradine, c. converting ivabradine in situ to its hydrochloride salt using alcoholic hydrogen chloride in an organic solvent; and d. isolating amorphous ivabradine hydrochloride.