Patent ID: 6274590
Filing Date: 2001-08-14
Classification: A61K,A61P,C07D

Abstract:
A method of treating a skin related condition selected from psoriasis, eczema, burns and dermatitis, in a subject, the method comprising administering to a subject having such condition, a therapeutically-effective amount of a compound of Formula I ##STR32##wherein Y is S;wherein X is one or more substituents selected froma) hydrido,halo,cyano,nitro,hydroxy,acyl,lower alkyl substituted with a substituent selected from halo, hydroxyl, amino, acylamino, lower alkylamino, lower alkyl(acyl)amino, acyl, aryl optionally substituted with hydroxyl, a heterocyclic group, hydroxyimino and lower alkoxyimino,lower alkenyl optionally substituted with cyano,amino optionally substituted with a radical selected from acyl and lower alkylsulfonyl,sulfo, sulfamoyl optionally substituted with a substituent selected from the group consisting of lower alkyl, halo-(lower) alkyl, aryl, hydroxyl, lower alkylamino(lower)alkyl, a heterocyclic group and (esterified carboxy)lower alkyl,N-containing heterocyclicsulfonyl,a heterocyclic group optionally substituted with a substituent selected from the group consisting of hydroxyl, oxo, amino and lower alkylamino,b) S(O).sub.n R.sup.5, wherein r.sup.5 is C.sub.1 -C.sub.6 alkyl optionally substituted with fluoro, and n is 0, 1 or 2,c) C(R.sup.5) (OR.sup.8) (R.sup.7), wherein R.sup.6 and R.sup.7 independently are selected from CF.sub.3, CF.sub.2 H, CFCl.sub.2, CF.sub.2 Cl, CClFH, CCl.sub.2 F, CF.sub.3 CF.sub.2 and C.sub.1 -C.sub.2 alkyl, wherein R.sup.8 is selected from hydrido, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkyl)C(O) and CO.sub.2 r.sup.9, and wherein R.sup.9 is C.sub.1 -C.sub.4 alkyl,d) C(O)ZR.sup.4, wherein Z is O, N, or S, and R.sup.4 is selected from hydrido, C.sub.1 -C.sub.6 alkyl and aryl, provided when Z is N then R.sup.4 is independently taken twice, ande) C(R.sup.9) (NHR.sup.11) (R.sup.10), wherein R.sup.9 and R.sup.10 are independently selected from CF.sub.3, CF.sub.2 H, CFCl.sub.2, CF.sub.2 Cl, CClFH and CCl.sub.2 H, and R.sup.11 is selected from hydrido and C.sub.1 -c.sub.3 alkyl; andwherein R.sup.2 and R.sup.3 are independently selected from aryl or heteroaryl, wherein the aryl or heteroaryl radical is optionally substituted with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower akylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amide, amino, lower alkylamino, sulfamyl and lower alkylsulfonylamino;provided that R.sup.2 is 4-methylsulfonylphenyl or 4-sulfamylphenyl;or a pharmaceutically-acceptable salt thereof.