Patent ID: 7341723
Filing Date: 2008-03-11
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for enhancing, in an animal, an immune response to an antigenic polypeptide of interest, said method comprising administering to said animal an effective amount of a composition comprising a nucleic acid construct encoding a fusion protein comprising a processing component and said antigenic polypeptide of interest wherein said processing component provides heterogeneous intracellular localisation to the membrane and cytosol compartments of the antigenic polypeptide when the nucleic acid construct is expressed in a host cell and a resulting enhancement of the immune response to the antigenic polypeptide, wherein said processing component is derived from N-terminal amino acids 1 to 100 of PORF2 protein of Hepatitis E Virus and comprises a sequence of 5 to 100 contiguous amino acids selected from said N-terminal amino acids 1 to 100.