Patent ID: 6716826
Filing Date: 2004-04-06
Classification: C07H,Y10S

Abstract:
A compound represented by the formula:Yâ€”Xâ€”1,6-chiro-inositol wherein:X represents a sugar radical; Y represents one to three sugar radicals; the sugar residue is unsubstituted or substituted with between one and four groups, and the chiro-inositol is unsubstituted or is further substituted with between one and four groups, the group or groups being independently selected from: (a) the phosphoryl groups phosphate, â€”Oâ€”P(O)(OH)2, thiophosphate, â€”Oâ€”P(S)(OH)2, phosphate esters, â€”Oâ€”P(O)(OH)2, thiophosphate esters, â€”Oâ€”P(S)(OR)2, phosphonate, â€”Oâ€”P(O)OHR, thiophosphonate, â€”Oâ€”P(S)OHR, substituted phosphonate, â€”Oâ€”P(O)OR1R2, substituted thiophosphonate, â€”Oâ€”P(S)OR1R2, â€”Oâ€”P(S)(OH)(SH) and cyclic phosphate; (b) the phosphorus-containing groups phosphoramidite, â€”Oâ€”P(OR)â€”NR1R2 and phosphoramidate, â€”Oâ€”P(O)(OR)â€”NR1R2; (c) the sulphur-containing groups â€”Oâ€”S(O)(OH), â€”SH, â€”SR, â€”S(â€”O)â€”R, â€”S(O)2R, ROâ€”S(O)2âˆ’, â€”Oâ€”SO2NH2, â€”Oâ€”SO2R1R2 or sulphamide â€”NHSO2NH2; (d) the amino groups â€”NHR, â€”NR1R2, â€”NHAc, â€”NHCOR, â€”NHâ€”Oâ€”COR, â€”NHSO3âˆ’, â€”NHSO2R, â€”N(SO2R)2; the amidino group, â€”NHâ€”C(&boxH;NH)NH2; and the ureido groups, â€”NHâ€”COâ€”NR1R2 or thiouriedo group, â€”NHâ€”C(S)â€”NH2; (e) the hydroxy group; the substituted hydroxy groups â€”OR3, where R3 is C1-10 unsubstituted or substituted alkyl, alkoxyalkyl, aryloxyalkyl, cycloalkyl, alkenyl (unsubstituted alkyl), alkylene (C3-7 cycloalkyl), â€”OCOR, aryl, heteroaryl, acetal, or said substituted groups comprise two hydroxyl groups that are joined to form a ketal; (f) the halogen substituents fluorine or chlorine; and (g) hydrogen, forming a deoxy sugar; wherein R, R1 and R2 are independently hydrogen or C1-10 unsubstituted or substituted alkyl or aryl, or derivatives thereof, said derivatives comprising physiologically tolerated salts, coordination complexes with metal ions, esters, free acids or bases, hydrates, prodrugs, or coupling partners selected from the group consisting of a reporter molecule, a substrate, a transport molecule, an effector, a drug, an antibody or an inhibitor.