Patent ID: 6303597
Filing Date: 2001-10-16
Classification: A61P,C07D

Abstract:
A compound of formula I, or a salt or prodrug thereof: ##STR13##whereinY represents hydrogen or C.sub.1-6 alkyl;Z represents a C.sub.6-8 bicycloalkyl moiety optionally substituted with one or two independent C.sub.1-6 alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, halogen, cyano, hydroxy, hydroxymethyl, C.sub.1-6 alkoxy or C.sub.3-7 cycloalkyl(C.sub.1-6)alkoxy substituents;R.sup.1 represents C.sub.3-7 cycloalkyl, phenyl, furyl, thienyl or pyridinyl, any of which groups may be optionally substituted with one or two independent C.sub.1-6 alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, halogen, cyano, hydroxy, hydroxymethyl, C.sub.1-6 alkoxy or C.sub.3-7 cycloalkyl(C.sub.1-6)alkoxy substituents; andR.sup.2 represents cyano(C.sub.1-6)alkyl, C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, propargyl, azetidinylcarbonyl(C.sub.1-6)alkyl, pyrrolidinylcarbonyl(C.sub.1-6)alkyl, piperidinylcarbonyl(C.sub.1-6)alkyl, piperazinylcarbonyl(C.sub.1-6)alkyl, morpholinylcarbonyl(C.sub.1-6)alkyl, thiomorpholinylcarbonyl(C.sub.1-6)alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, pyridinyl(C.sub.1-6)alkyl, quinolinyl(C.sub.1-6)alkyl, isoquinolinyl(C.sub.1-6)alkyl, pyridazinyl(C.sub.1-6)alkyl, pyrimidinyl(C.sub.1-6)alkyl, pyrazinyl(C.sub.1-6)alkyl, quinoxalinyl(C.sub.1-6)alkyl, furyl(C.sub.1-6)alkyl, benzofuryl(C.sub.1-6)alkyl, dibenzofuryl(C.sub.1-6)alkyl, thienyl(C.sub.1-6)alkyl, benzthienyl(C.sub.1-6)alkyl, pyrrolyl(C.sub.1-6)alkyl, indolyl(C.sub.1-6)alkyl, pyrazolyl(C.sub.1-6)alkyl, indazolyl(C.sub.1-6)alkyl, oxazolyl(C.sub.1-6)alkyl, isoxazolyl(C.sub.1-6)alkyl, thiazolyl(C.sub.1-6)alkyl, isothiazolyl(C.sub.1-6)alkyl, imidazolyl(C.sub.1-6)alkyl, benzimidazolyl(C.sub.1-6)alkyl, oxadiazolyl(C.sub.1-6)alkyl, thiadiazolyl(C.sub.1-6)alkyl, triazolyl(C.sub.1-6)alkyl, or tetrazolyl(C.sub.1-6)alkyl, any of which groups may be optionally substituted with one or two independent C.sub.1-6 alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, halogen, cyano, hydroxy, hydroxymethyl, C.sub.1-6 alkoxy or C.sub.3-7 cycloalkyl(C.sub.1-6)alkoxy substituents.