Patent ID: 6809077
Filing Date: 2004-10-26
Classification: A61P,C07K,Y10S

Abstract:
A cyclosporin analog of formula (I) or a pro-drug or a pharmaceutically acceptable salt thereof; wherein(i) A is of the formula: â€ƒwherein: X is absent, â€”C1-C6 alkyl-, or â€”C3-C6 cycloalkyl-; Y is selected from the group consisting of: (a) aryl substituted with one or more substituents independently selected from: â€”CN, C3-C8-alkoxy, C1-C6-alkoxy, C3-C6-alkoxy substituted with aryl, haloalkyl, thioalkoxy, amino, alkylamino, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl, or carboxamide; (b) heteroaryl; or (c) substituted heteroaryl; (ii) B is -&agr;Abu-, -Val-, -Thr- or -Nva-; and (iii) U is -(D)Ala-, -(D)Ser-, â€”[O-(2-hydroxyethyl)(D)Ser]-, â€”[O-(acyl)(D)Ser]- or â€”[O-(2-acyloxyethyl)(D)Ser]-.