Patent ID: 9017724
Filing Date: 2015-04-28
Classification: A61B,A61K,A61P,C07B,C07D,C07F

Abstract:
1. A method of making a radiofluorinated compound, represented by A-Y, by reacting a substrate, represented by A-X, with a radiofluorinating agent, represented by MY, wherein A is (i)a 5-, 6-, or 7-membered single-ring aromatic group that includes no heteroatoms in its ring structure, or (ii) a polycyclic ring system having two or more fused rings wherein at least one of the rings is a 5-, 6-, or 7-membered single-ring aromatic group that includes no heteroatoms in its ring structure, and A does not contain an activating group to enhance the reactivity of X; X is sulfonate, nitro, acetate, or halogen; M is an alkali metal or transition metal; Y is radioactive fluoride; A is non-covalently bound to a transition metal or transition metal cation to form a transition metal complex; the method is practiced under substantially anhydrous conditions; the reaction temperature is between about 50 ° C. and about 220 ° C ; and the synthesis of A-Y is completed within two hours.