Patent ID: 6573260
Filing Date: 2003-06-03
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (I) its salts and hydrates thereof: wherein R1 and R2 each independently represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, in which the alkyl group may have one or more substituents selected from the group consisting of hydroxyl group, a halogen atom, an alkylthio group having 1 to 6 carbon atoms and an alkyloxy group; n is an integer of 1 to 4; and Q is a partial structure represented by the following formula (Ia): wherein R3 represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a halogenoalkyl group having 1 to 6 carbon atoms, a cyclic alkyl group having 3 to 6 carbon atoms which may have a substituent, with the proviso that when R3 is a cyclopropyl group it is substituted by a halogen compound an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an alkoxyl group having 1 to 6 carbon atoms or an alkylamino group having 1 to 6 carbon atoms; R4 represents a hydrogen atom or an alkylthio group having 1 to 6 carbon atoms; R4 and R3 may form together with a part of the mother skeleton a ring structure optionally containing a sulfur atom as a ring constituting atom thereof and optionally having an alkyl group having 1 to 6 carbon atoms as a substituent; R5 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms or an alkoxyl group having 1 to 6 carbon atoms, in which the amino group may have one or more substituents selected from the group consisting of a formyl group, an alkyl group having 1 to 6 carbon atoms and an acyl group having 2 to 5 carbon atoms; X1 represents a halogen atom or a hydrogen atom; A1 represents a nitrogen atom or a partial structure represented by formula (II): wherein X2 represents a hydrogen atom, an amino group, a halogen atom, a cyano group, a halogenomethyl group, a halogenamethoxyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms or an alkoxyl group having 1 to 6 carbon atoms, in which the amino group may have one or more substituents selected from the group consisting of a formyl group, an alkyl group having 1 to 6 carbon atoms and an acyl group having 2 to 5 carbon atoms; and X2 and R3 may form together with a part of the mother skeleton a ring structure optionally containing an oxygen atom, a nitrogen atom or sulfur atom as a ring constituting atom thereof and optionally having an alkyl group having 1 to 6 carbon atoms as a substituent; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms or a phenylalkyl group composed of an alkylene group having 1 to 6 carbon atoms and a phenyl group.