Patent ID: 7501484
Filing Date: 2009-03-10
Classification: C07K,C12N,C12P

Abstract:
1. A polypeptide comprising in tandem: a) a first region comprising an inclusion body fusion partner having an amino acid sequence comprising SEQ ID NO: 2; and b) a second region not naturally associated with the first region comprising a preselected amino acid sequence selected from the group consisting of amino acids 7-36 of GLP-1 (SEQ ID NO: 31), amino acids 7-36 of GLP-1 (SEQ ID NO: 31) further consisting of an amide linkage at the C-terminus, amino acids 7-37 of GLP-1 (SEQ ID NO: 32), amino acids 7-37 of GLP-1 (SEQ ID NO: 32) further consisting of an amide linkage at the C-terminus, amino acids 7-36 of GLP-1 further consisting of a K to R substitution at position 26 (SEQ ID NO: 33), amino acids 7-36 of GLP-1 further consisting of a K to R substitution at position 26 (SEO ID NO:33) and further consisting of an amide linkage at the C-terminus, amino acids 7-37 of GLP-1 further consisting of a K to R substitution at position 26 (SEQ ID NO: 34), amino acids 7-37 of GLP-1 further consisting of a K to R substitution at position 26 SE ID NO:34 and further consisting of an amide linkage at the C-terminus (SEQ ID NO: 34), amino acids 1-34 of GLP-2 (SEQ ID NO: 35), amino acids 1-34 of GLP-2 (SEQ ID NO: 35) and further consisting of an amide linkage at the C-terminus, amino acids 1-33 of GLP-2 (SEQ ID NO: 36), amino acids 1-33 of GLP-2 (SEQ ID NO: 36) and further consisting of an amide linkage at the C-terminus, amino acids 1-33 of GLP-2 further consisting of an A to G substitution at position 2 (SEQ ID NO: 37), amino acids 1-33 of GLP-2 further consisting of an A to G substitution at position 2 (SEQ ID NO: 37) and further consisting of an amide linkage at the C-terminus, amino acids 1-34 of GLP-2 further consisting of an A to G substitution at position 2 (SEQ ID NO: 38), amino acids 1-34 of GLP-2 further consisting of an A to G substitution at position 2 (SEQ ID NO: 38) and further consisting of an amide linkage at the C-terminus, amino acids 1-44 of GRF (SEQ ID NO: 39), amino acids 1-34 of (SEQ ID NO: 40), amino acids 1-37 of PTH (SEQ ID NO: 41), amino acids 1-84 of PTH (SEQ ID NO: 42), amino acids 27-38 of Amyloid P Component (SEQ ID NO: 43) and further consisting of an amide linkage at the C-terminus, (Tyr0)-Fibrinopeptide A (SEQ ID NO: 44), Urechistachykinin II (SEQ ID NO: 45), amino acids 12-28 of Amyloid β-Protein (SEQ ID NO: 46), amino acids 22-35 of Amyloid β-Protein (SEQ ID NO: 47), camel β-Endorphin (SEQ ID NO: 48), porcine Valosin (SEQ ID NO: 49), and mouse Vasoactive Intestinal Contractor Peptide (SEQ ID NO: 50).