Patent ID: 6780613
Filing Date: 2004-08-24
Classification: C07K,C12N,Y10S

Abstract:
A DNA molecule comprising a nucleic acid sequence encoding a variant of a human growth hormone that binds to a target with an affinity different from the affinity of said human growth hormone for said target, wherein the amino acid sequence of said variant is not found in nature, and said variant comprises an amino acid substitution at an amino acid residue selected from the group consisting of P2, T3, P5, S7, L9, N12, L15, R16, R19, E30, E33, S43, F44, Q46, N47, P48, Q49, T50, F54, S55, E56, S57, I58, P59, S62, N63, F66, Q68, K70, S71, L73, R77, L80, F97, A98, N99, S100, L101, V102, Y103, G104, D169, T175, R178, Q181, C182, R183, S184, V185, E186, G187, S188, and F191, numbered from the N-terminus of 191-amino acid human growth hormone, wherein said variant is not hGH-V.