Patent ID: 6372730
Filing Date: 2002-04-16
Classification: A61P,C07F

Abstract:
A compound having the following structure: wherein R1 is H or lower alkyl; R2 is H, alkyl, heteroalkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring; X is O or S; Y is O, S or NH; V is C4 alkyl or M4 heteroalkyl; a is single bond, cis double bond, or trans double bond; b is single bond, trans double bond, or triple bond; when a is single bond, W is OH or N(R3)(OR4); wherein R3 is selected from H, lower alkyl, or lower heteroalkyl; wherein said lower alkyl is unsubstituted or substituted with from 1 to about 3 substituents selected from the group consisting of: hydroxyl, halo, thiol, and nitrile; and wherein said lower heteroalkyl is unsubstituted or substituted with from 1 to about 3 substituents selected from the group consisting of: hydroxyl, halo, thiol, and nitrile; and R4 is H, lower alkyl, or lower heteroalkyl; when a is cis double bond or trans double bond, W is N(OR4); wherein R4, is as defined above; Z is C1 alkyl, M1 heteroalkyl, Cm alkyl-G', Mn heteroalkyl-G', Cp alkyl-Gâ€ , or Mq heteroalkyl-Gâ€ ; wherein 1 is an integer from about 3 to about 7; m is an integer from 0 to about 5; n is an integer from about 2 to about 5; p is an integer from 0 to about 3; q is 2 or 3; G' is monocyclic carbocyclic aliphatic ring, monocyclic heterocyclic aliphatic ring, monocyclic aromatic ring or monocyclic heteroaromatic ring; Gâ€  is bicyclic carbocyclic aliphatic ring, bicyclic heterocyclic aliphatic ring, bicyclic aromatic ring or bicyclic heteroaromatic ring; and any pharmaceuticallyâ€”acceptable salt, or biohydrolyzable amide, ester, or imide thereof.