Patent ID: 6323215
Filing Date: 2001-11-27
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR83##or a pharmaceutically acceptable salt thereof wherein(a) R.sup.1 is selected from the group consisting of(i) COCOR.sup.2, wherein R.sup.2 is (C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl, (C.sub.5 -C.sub.7)-cycloalkyl, 2-thienyl, 3-thienyl, phenyl, or substituted phenyl (the substituted phenyl ring having one to three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, hydroxy and halogen),(ii) CONHR.sup.3, wherein R.sup.3 is (C.sub.1 -C.sub.6)-straight or branched alkyl, and(iii) SO.sub.2 R.sup.4, wherein R.sup.4 is phenylalkyl or substituted phenylalkyl (the substituted phenyl ring having one to three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, hydroxy and halogen);(b) X is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, hydroxy and halogen;(c) Y is O or NR.sup.5, wherein R.sup.5 is (C.sub.1 -C.sub.6)-straight or branched alkyl;(d) Z is cyclohexyl(C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.5)-straight or branched alkyl or (C.sub.2 -C.sub.5)-straight or branched alkenyl substituted in one or more positions with Ar, which Ar is selected from the group consisting of 2-pyridyl, 3-pyridyl, 4-pyridyl, phenyl and substituted phenyl (the substituted phenyl ring having from one to three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, hydroxy and halogen), with the proviso that Z and R.sup.2 cannot both be C.sub.1 -alkyl, and when Z is (C.sub.1 -C.sub.5)alkyl, Ar is not phenyl; and(e) A is S or CH.dbd.CH.