Patent ID: 7316900
Filing Date: 2008-01-08
Classification: A61K,A61P,C12N,C12Q,C12Y

Abstract:
1. An oligonucleotide that is from 15 to 150 nucleotides in length wherein said oligonucleotide comprises a nucleic acid sequence that is exactly complementary to at least one CpG island present in a portion of a nucleic acid molecule having a nucleotide sequence of nucleotide position 1 to nucleotide position 1226 of SEQ ID NO: 18, and wherein said oligonucleotide: (i) forms a stable complex in a mammalian cell with said portion of said nucleic acid molecule; and (ii) comprises one or more 5-methylated cytosines complementary to a guanosine of said CpG island.