Patent ID: 6166015
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A compound selected from compounds of Formula (I): ##STR34## Z is --N-- or --(N.sup.+ R)--X.sup.- wherein R is alkyl, haloalkyl, aralkyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, or cyanoalkyl, and X.sup.- is a pharmaceutically acceptable counterion;Ar.sup.1 and Ar.sup.2 are, independently of each other, aryl or heteroaryl;Q is a straight or branched alkylene chain of 1-3 carbon atoms;R.sup.1 is hydrogen or alkyl;A is either:(I) --N(R.sup.2)C(O)-- when:B is:(i) an alkylene chain of 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from --C(O)--, --N(R.sup.4)--, --O--, --S(O).sub.n -- (where n is 0, 1 or 2), --NR.sup.5 C(O)-- and --N(R.sup.6)SO.sub.2 --; or(ii) an alkynylene chain;wherein:R.sup.2 is hydrogen, alkyl, acyl, haloalkyl, heteroalkyl, heterocyclylalkyl, or -(alkylene)--C(O)--Z' where Z' is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, or mono- or disubstituted amino; andR.sup.4, R.sup.5 and R.sup.6 are, independently of each other, hydrogen, alkyl, acyl, haloalkyl, heteroalkyl, heterocyclylalkyl, or -(alkylene)--C(O)--Z' where Z' is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, or mono- or disubstituted amino; or(II) a group selected from --N(R.sup.2)C(S)--, --N(R.sup.2)C(O)N(R.sup.3)--, --N(R.sup.2)C(S)N(R.sup.3)--, --N(R.sup.2)SO.sub.2 --, --N(R.sup.2)SO.sub.2 N(R.sup.3)--, --N(R.sup.2)C(O)O--, and --OC(O)N(R.sup.3)-- when:B is:(i) a bond;(ii) an alkylene chain of 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from --C(O)--, --N(R.sup.4)--, --O--, --S(O).sub.n -- (where n is 0, 1 or 2), --NR.sup.5 C(O)-- and --N(R.sup.6)SO.sub.2 --;(iii) an alkenylene chain; or(iv) an alkynylene chain;wherein:R.sup.3 is hydrogen, alkyl, acyl, haloalkyl, heteroalkyl, heterocyclylalkyl, or -(alkylene)--C(O)--Z' where Z' is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, or mono- or disubstituted amino; andR.sup.2, R.sup.4, R.sup.5 and R.sup.6 are as defined above; andprodrugs, individual isomers, mixtures of isomers and pharmaceutically acceptable salts thereof.