Patent ID: 6545007
Filing Date: 2003-04-08
Classification: A61K,A61P,C07D

Abstract:
A method for inhibiting sexual transmission of HIV comprising topically applying to the skin or epithelial tissue of a human an effective amount of a dihydro-alkyloxy-benzyl-oxopyrimidine of formula (A): wherein:a) X is â€”NK2; b) K2 is â€”H, â€”C1-4alkyl, â€”C3-6cycloalkyl, or a bond when Xâ€”R is Nâ†‘O; c) R is â€”H, â€”C1-4alkyl (optionally containing one or more of heteroatoms selected from O, S, and N), â€”C3-6cycloalkyl (optionally containing one or more of heteroatoms selected from O, S, and N), -aryl, -arylalkyl, heterocycle, or oxo; d) Y is â€”H, â€”C1-4alkyl, or â€”C3-6cycloalkyl; e) Z is â€”H, â€”C1-4alkyl, or â€”C3-6cycloalkyl; f) R1, R2, R3, R4, and R5, are independently selected from â€”H, â€”C1-4alkyl, -halogen, â€”NO2, â€”OW, or â€”SW; and g) W is â€”H, â€”CH3, or -aryl.