Patent ID: 8138190
Filing Date: 2012-03-20
Classification: A61P,C07D

Abstract:
1. A method for treating a condition or disorder, the method comprising administering to a patient suffering from said condition or disorder a therapeutically effective amount of a compound having the formula (I): a pharmaceutically acceptable salt, or stereoisomer thereof, or a mixture thereof, wherein: X is —C(R R R R R R R optionally, R Q is selected from the group consisting of a bond, (C wherein n, at each occurrence, is 0 or 1; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, (C wherein when Q is a bond, then Y is not hydrogen; R the subscript m is 1 or 2; wherein any cycloalkyl portion, heterocycloalkyl portion, aryl portion or heteroaryl portion is optionally substituted with from one to four members selected from oxo, aryl(C wherein each occurrence of R′ is independently hydrogen or an unsubstituted member selected from (C optionally, two R′ groups, when attached to the same nitrogen atom, is combined with the nitrogen atom to which they are attached to form a heterocycle or a heteroaryl group; wherein each occurrence of R″ is independently an unsubstituted member selected from (C wherein the condition or disorder is selected from the group consisting of diabetes, syndrome X, obesity, hypertriglyceridemia, hyperinsulinemia, age-related cognitive disorders, dementia, depression, osteoporosis, an inflammatory disorder and an immune disorder; wherein said compound is other than 2-[[4-[(4-methylphenyl)sulfonyl]-1-piperazinyl]carbonyl-benzoic acid, 1-(4-methylbenzoyl)-4[(4-methylphenyl)sulfonyl])-piperazine, 1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindo-2-yl)-1-oxopropyl]-4-[(4-methylphenyl)sulfonyl]-piperazine, N-[2-(4-fluorophenyl)ethyl]-4-[(4-methylphenyl)sulfonyl]-gamma-oxo-1-piperazinebutanamide, 3-chloro-N-(2-[4-[(4-methylphenyl)sulfonyl]-1-piperazineyl]-2-oxoethyl]-5-nitro benzamide, 1-[[4-(2-methylphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-ylthio]acetyl]-4-[(4methylphenyl)sulfonyl]-piperazine, 1-[[[3,4-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl]thio]acetyl]-4-[(4-methylphenyl)sulfonyl]-piperazine, 1-[(4-methylphenyl)sulfonyl]-4-[[5,6,7,8-tetrahydro[1]benzothieno[2,3 -d]pyrimidin-4-yl)thio]acetyl]-piperazine, 1-[[[3,4-dihydro-4-oxo-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]thio]acetyl]-4-[[4-methylphenyl)sulfonyl]-piperazine, 1-[(2,4-dimethylphenyl)sulfonyl]-4-(phenylacetyl)-piperazine or 2-(methylthio)-2-[4-[(4-methylphenyl)sulfonyl]-1-piperazinyl]-2-oxoethyl benzoic acid.