Patent ID: 6531277
Filing Date: 2003-03-11
Classification: G01N,Y10S

Abstract:
A method of diagnosing endometriosis in a female patient suspected of having endometriosis by:(a) obtaining a uterine endometrial tissue sample from the patient; and (b) detecting an aberrant expression of a protein in the sample, wherein the aberrant expression presence of the protein indicates a diagnosis of endometriosis, the protein designated ENDO-1 and characterized by (i) having a molecular weight of 40,000 to 55,000 as determined by two-dimensional SDS-PAGE polyacrylamide gel electrophoresis; (ii) having an isoelectrlc point of 4.0 to 5.5; (iii) being synthesized and secreted specifically by stromal cells of endometriotic tissue origin; and (v) being encoded in part by a cDNA sequence consisting of SEQ ID No: 1.