Patent ID: 6288031
Filing Date: 2001-09-11
Classification: A01N,A61F,A61K,A61L,C07K

Abstract:
A method for reducing inflammatory response in a patient with tissue damage, the method comprising:administering a morphogen other than TGF-.beta..sub.2 to the patient, said morphogen(a) comprising a dimeric protein having an amino acid sequence that has at least 70% amino acid sequence homology with the C-terminal seven-cysteine skeleton of human OP-1, amino acids 38-139 of SEQ ID NO:5,(b) wherein said morphogen induces endochondral bone formation in an in vivo assay, andwherein the damaged tissue is a non-periodontal tissue, and wherein said administration of said morphogen reduces adherence of activated immune effector cells to vascular endothelium, thereby reducing inflammatory response in the patient.