Patent ID: 8124766
Filing Date: 2012-02-28
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: X is oxygen, sulfur or nitrogen; Y is carbon or nitrogen; Z is carbon or nitrogen; R1 is lower alkyl, halo lower alkyl, alkoxy, lower alkyl alkoxy or absent; R2, R2′, independently of each other, is halogen, alkoxy, lower alkyl, haloloweralkyl, haloalkoxy, benzyloxy or absent; R3 is hydrogen or lower alkyl, wherein if X is oxygen or sulfur, then R3 is absent; and Q is piperazine-1-carboxylic acid lower alkyl ester, piperidine-1-carboxylic acid lower alkyl ester, piperazin-1-yl-2,2-dimethyl-4-oxo-lower akanoic acid, piperidin-1-yl-2,2-dimethyl-4-oxo-lower alkanoic acid, piperazine-1-carbonyl-4-cyclohexanecarboxylic acid benzyl ester, piperazine-1-carbonyl-4-cyclohexanecarboxylic acid, piperidine-1-carbonyl-4-cyclohexanecarboxylic acid, piperazine-1-carbonyl-2-cyclopentanecarboxylic acid, N-lower alkoxy lower alkyl-N-lower alkyl-amino, N-cycloloweralkyl-N-lower alkyl-amino, N-pyrrolidine-1-carboxylic acid lower alkyl ester, O-pyrrolidine-1-carboxylic acid lower alkanoic ester, O-pyrrolidine-1-carboxylic acid lower alkyl ester, pyrrolidine-3-ylamino-1-carboxylic acid lower alkyl ester, pyrrolidin-3-ylamino-1-carboxylic acid lower alkyl amide, piperidin-1-yl-4-oxo-2-phenyl-lower alkanoic acid, piperidine-1-carbonyl-2-cyclopentanecarboxylic acid, piperidin-1-yl-2-oxo-lower alkyl-cyclopentanecarboxylic acid, piperazin-1-yl-4-oxo-lower alkyl acid, piperidin-1-yl-4-oxo-lower alkanoic acid, piperazin-1-yl-2-oxo-ethyl-3-methyl-lower alkanoic acid, piperazin-1-yl-4-oxo-2-cyclohexyl-butyric acid, pyrrolidine-3-oxy-1-carboxylic acid lower alkyl ester, pyrrolidine-3-oxy-1-carboxylic acid lower alkyl ester, pyrrolidin-3-oxy-1-yl-2,2-dimethyl-4-oxo-lower alkanoic acid, pyrrolidin-3-oxy-1-yl-4-benzoic acid, 2,4-dioxo-thiazolidin-5-yl-acetyl-piperazin-1-yl or piperazin-1-yl-4-benzoic acid, or a pharmaceutically acceptable salt thereof.