Patent ID: 8388933
Filing Date: 2013-03-05
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of treating a disease, said method comprising administering to a patient suffering from the disease a composition that comprises a first effector component of a multimeric bacterial protein toxin, the first effector component comprising at least a first modified monomer and a second modified monomer, wherein said first and second modified monomers form a heterooligomer, wherein said first and second modified monomers are different, and wherein said first and second modified monomers are generated by modification of a first and second unmodified monomers, respectively, the modification of each of said first and second unmodified monomers meeting at least one of the following criteria: (a) substitution of a native cell-recognition domain in said first or second unmodified monomer for a non-native cell-recognition domain, wherein cells characteristic of the disease are recognized by the non-native cell-recognition domain; and (b) substitution of a native proteolytic activation site in said first or second unmodified monomer for a non-native proteolytic activation site, wherein cells characteristic of the disease express a protease cleaving at the non-native proteolytic activation site.