Patent ID: 7488828
Filing Date: 2009-02-10
Classification: C07D

Abstract:
1. A process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone (I), which comprises: i) contacting either a 4-alkoxy-1,1,1-trifluorobut-3-en-2-one of the formula in which R represents C 1 -C 4 alkyl, or a 4,4-dialkoxy-1,1,1-trifluorobutan-2-one of the formula in which R is as previously defined, with a trialkyl phosphonoacetate of the formula: in which R is as previously defined, in the presence of a base and an alcohol or glycol solvent to provide a mixture of condensation products of the formula in which R is as previously defined; and ii) cyclizing the mixture of condensation products to provide 4-trifluoromethyl-2(1H)-pyridinone.