Patent ID: 7846479
Filing Date: 2010-12-07
Classification: A61K,A61P

Abstract:
1. A method of producing a microparticle composition, said method comprising: (a) forming an emulsion comprising (i) a polymer selected from the group consisting of a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and a polycyanoacrylate, (ii) an organic solvent, (iii) a detergent and (iv) water; (b) removing the organic solvent from the emulsion to form a microparticle suspension; (c) wherein said microparticle suspension is subjected to a filtration step to remove excess detergent such that about 10-90% of the total detergent in the resulting microparticle suspension is bound to the microparticles and the remainder is unbound, or wherein said microparticle suspension is not subjected to a step to remove excess detergent and the ratio of the detergent to the polymer used is such that about 10-90% of the total detergent in the microparticle suspension is bound to the microparticles and the remainder is unbound; and (d) mixing a biologically active macromolecule with said microparticle suspension in which about 10-90% of the total detergent in the microparticle suspension is bound to the microparticles and the remainder is unbound such that said biologically active macromolecule is adsorbed to microparticles in said suspension.