Patent ID: 7094398
Filing Date: 2006-08-22
Classification: C12N

Abstract:
1. A recombinant, double-stranded, adenovirus vector, wherein the vector comprises: a. an adenovirus left inverted terminal repeat sequence; b. an adenovirus packaging sequence; c. a first adenoviral-associated inverted terminal repeat sequence; d. a first inverted repeat sequence; e. a heterologous promoter sequence which mediates transcription in a direction towards the adenoviral left inverted terminal repeat sequence in part a; f. a foreign gene sequence; g. a second inverted repeat sequence; h. a second adenoviral-associated inverted terminal repeat sequence; i. a gene sequence that mediates replication of an adenovirus in a transduced cell; and j. an adenovirus right inverted terminal repeat sequence; wherein the adenovirus packaging sequence is located on the one strand of the double-stranded vector; and wherein the other of the two strands of the double-stranded vector comprises a nucleotide sequence encoding a modified adenoviral fiber protein which alters the tropism of the adenovirus vector, and wherein the modified adenoviral fiber protein is a modified fiber knob, a modified fiber tail or a modified fiber shaft.