Patent ID: 6537594
Filing Date: 2003-03-25
Classification: A61K,A61P,C07K,C12N

Abstract:
A composition for inducing an antigenic or immunological response, said composition comprising a recombinant poxvirus in admixture with a suitable carrier, wherein said recombinant poxvirus contains in a non-essential region an exogenous DNA sequence comprising the coding sequences for a cytokine and/or tumor-associated antigen wherein said recombinant poxvirus expresses the exogenous DNA sequence and said recombinant poxvirus is a recombinant vaccinia virus wherein regions C7-K1L, J2R, B13R+B14R, A56R, A26L, and I4L have been deleted therefrom, or wherein the open reading frames for the thymidine kinase gene, the hemorrhagic region, the A type inclusion body region, the hemagglutinin gene, the host range gene region, and the gene for the large subunit of ribonucleotide reductase have been deleted therefrom.