Patent ID: 9200276
Filing Date: 2015-12-01
Classification: A61P,C12N

Abstract:
1. A polynucleotide complex consisting of: a first polynucleotide that is fully or partially complementary to a first target sequence, and wherein the first polynucleotide is approximately 15-30 nucleotides in length; a second polynucleotide that is fully or partially complementary to a second target sequence, and wherein the second polynucleotide is approximately 15-30 nucleotides in length; and a third polynucleotide that is either (a) fully or partially complementary to a third target sequence or (b) not specific to any target sequence, and wherein the third polynucleotide is approximately 15-30 nucleotides in length; wherein a 3′ region of the first polynucleotide is complementary to a 5′ region of the second polynucleotide, where a 3′ region of the second polynucleotide is complementary to a 5′ region of the third polynucleotide, and wherein a 3′ region of the third polynucleotide is complementary to a 5′ region of the first polynucleotide; and wherein the first, second, and third polynucleotides hybridize via the complementary 3′ and 5′ regions to form a polynucleotide complex with a first, second, and third stem region.