Patent ID: 6087130
Filing Date: 2000-07-11
Classification: A01K,C07K,C12N,G01N

Abstract:
An antibody substance selected from the group consisting of monoclonal antibodies, singe chain antibodies, chimeric antibodies, CDR-grafted antibodies, humanized antibodies and antibody fragments thereof, which specifically binds a domain of Intercellular Adhesion Molecule-R (ICAM-R) selected from the group consisting of:(a) the third extracellular domain of ICAM-R (amino acid residues 188 to 285 of SEQ ID NO: 1);(b) the fourth extracellular domain of ICAM-R (amino acids 286 to 387 of SEQ ID NO: 1);(c) the fifth extracellular domain of ICAM-R (amino acids 388 to 456 of SEQ ID NO: 1); and(d) the cytoplasmic domain of ICAM-R (amino aids 482 to 518 of SEQ ID NO: 1).