Patent ID: 6433169
Filing Date: 2002-08-13
Classification: C07D

Abstract:
A process for the preparation of a 2-alkoxy-6-trifluoromethyl-N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide of Formula I whereinW represents H or O(C1-C3 alkyl); Z represents H or O(C1-C3 alkyl), with the proviso that at least one of W or Z represents O(C1-C3 alkyl); and R represents C1-C4 alkyl optionally substituted with at least 2 and up to the maximum possible number of fluorine atoms which comprises contacting a 2-fluoro-6-trifluoromethyl-N-([1,2,4]triazolo-[1,5-c]pyrimidin-2-yl)benzenesulfonamide of Formula II whereinW and Z are as previously defined with an alcohol ROH wherein R is as previously defmed and at least 2 molar equivalents of base in a polar aprotic organic solvent.