Patent ID: 6127162
Filing Date: 2000-10-03
Classification: C07K,C12N

Abstract:
An isolated polynucleotide encoding a human prohormone convertase 4 polypeptide comprising a sequence of amino acid residues that is at least 90% identical to an amino acid sequence selected from the group consisting of:(a) the amino acid sequence as shown in SEQ ID NO:2 from amino acid number 114 (Ser) to amino acid number 443 (Ala);(b) the amino acid sequence as shown in SEQ ID NO:2 from amino acid number 114 (Ser) to amino acid number 755 (Thr);(c) the amino acid sequence as shown in SEQ ID NO:2 from amino acid number 20 (Arg) to amino acid number 755 (Thr); and(d) the amino acid sequence as shown in SEQ ID NO:2 from amino acid number 1 (Met) to amino acid number 755 (Thr), andwherein the prohormone convertase polypeptide encoded by the polynucleotide sequence has prohormone convertase activity.