Patent ID: 6060281
Filing Date: 2000-05-09
Classification: C07K,C12N

Abstract:
An isolated nucleic acid molecule selected from the group consisting of: (a) a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:18, and SEQ ID NO:19; (b) a nucleic acid molecule comprising a homologue of a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, wherein said nucleic acid homologue encodes a protein containing one or more amino acid deletions, substitutions, or insertions, wherein said protein encoded by said homologue comprises at least one epitope comprising at least 5 contiguous amino acids that elicits an immune response against a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5 and SEQ ID NO:7, wherein said homologue has at least a 15 contiguous nucleic acid portion identical in sequence to a contiguous 15 nucleic acid portion of sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, wherein said homologue is of a D. immitis nucleic acid molecule; and (c) a nucleic acid molecule that is fully complementary to any of said nucleic acid molecules of (a) or (b).