Patent ID: 8415461
Filing Date: 2013-04-09
Classification: A61K

Abstract:
1. An amphiphilic substance, comprising: a polynucleotide group comprising a first polynucleotide segment and a second polynucleotide segment that is at least partially complementary to the first polynucleotide segment, wherein the first polynucleotide segment comprises an aptamer, and wherein base pairing between the first polynucleotide segment and the second polynucleotide segment occurs in an absence of binding of an effector specific for the aptamer and base pairing between the first polynucleotide segment and the second polynucleotide segment is disrupted in the presence of the effector; a hydrophobic group attached to only one of the first polynucleotide segment and the second polynucleotide segment; and a stabilizing group, attached to the first or second polynucleotide segment that is not attached to the hydrophobic group, where the stabilizing group is different from the hydrophobic group and the first and second polynucleotide segments.