Patent ID: 7837999
Filing Date: 2010-11-23
Classification: A61K,A61P,C07K

Abstract:
1. A method for increasing muscle mass in a subject that has a disease or condition which is accompanied by a decrease in muscle mass, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a fusion polypeptide and a pharmaceutically acceptable carrier to a subject in need thereof, thereby increasing muscle mass, wherein the fusion polypeptide comprises (a) an insulin-like growth factor 1 (IGF1) variant polypeptide component comprising a human IGF1 protein of SEQ ID NO:1 with deletions of amino acid residues 1-3, 37, and 65-70; and (b) a fusion component (F); wherein F is an Fc domain of human IgG, wherein the IGF1 variant polypeptide component retains the functional activity of IGF1.