Patent ID: 6150356
Filing Date: 2000-11-21
Classification: A61P,C07C,C07D

Abstract:
A compound having the structure ##STR459## including pharmaceutically acceptable salts thereof, prodrug esters thereof, and all stereoisomers thereof, whereinA, B and D are CH;X.sup.1 is ##STR460## wherein the oxygen atom is linked to the aromatic ring; (where R.sup.3 and R.sup.4 are independently H, alkyl, arylalkyl or cycloalkyl, or R.sup.3 and R.sup.4 can be taken together with the carbon to which they are attached to form a 5 to 8 carbon containing ring);R is H, alkyl, alkenyl, aryl, arylalkyl, heterocycloalkyl, cycloalkyl, or cycloalkylalkyl;R.sup.1 is alkyl, arylalkyl, aryl, alkenyl, heterocyclo, heterocycloalkyl, ##STR461## (where R.sup.5a can be H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl), cycloalkyl, cycloalkylalkyl or ##STR462## (where R.sup.6 and R.sup.7 are independently selected from H, aryl, alkyl, arylalkyl or cycloalkyl, or R.sup.6 and R.sup.7 can be taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered ring); or R and R.sup.1 can be taken together with the --N--S--atoms to form a 5- to 8-membered ring;X.sup.2 is a single bond, ##STR463## or --O-- (where R.sup.8 is H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl);R.sup.2 is H, alkyl, arylalkyl, ##STR464## (where R.sup.10 and R.sup.11 are independently selected from H, alkyl, arylalkyl or cycloalkyl, or R.sup.10 and R.sup.11 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring); andQ is ##STR465## (where R.sup.12 is ##STR466## heterocycle, heterocycloalkyl, ##STR467## where R.sup.14 can be any of the R.sup.8 groups), CF.sub.3, aryloxy, arylalkoxy, cycloalkyl or cycloalkylalkyl), and where R.sup.15 and R.sup.16 are independently selected from H, alkyl, arylalkyl, heterocyclo, cycloalkyl, amino, aminoalkyl or heterocycloalkyl, or R.sup.15 and R.sup.16 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring which may optionally contain an additional nitrogen atom in the ring and/or an amino group or an aminoalkyl group attached to the ring; andR.sup.13 is ##STR468## (wherein this moiety is as defined with respect to R.sup.12 and at least one of R.sup.15 and R.sup.16 is other than lower alkyl);wherein the term heterocyclo by itself or as part of heterocycloalkyl refers to a cycloheteroalkyl group or a heteroalkyl group wherein cycloheteroalkyl is a 5-, 6- or 7-memebered saturated ring which includes 1 to 2 hetero atoms which are nitrogen, oxygen and/or sulfur, which may be optionally substituted with 1 to 4 substituents, and which optionally can be fused to a cycloalkyl, aryl, heteroaryl or cycloheteroalkyl ring, and heteroaryl is a 5- or 6-membered aromatic ring which includes 1, 2, 3 or 4 hetero atoms which are nitrogen, oxygen and/or sulfur, which may be optionally substituted with 1 or 2 substituents, and which optionally can be fused to an aryl, cycloalkyl, heteroaryl or cycloheteroalkyl ring;with the provisos that(1) where Q is ##STR469## R.sup.12 or R.sup.13 is ##STR470## then at least one of R.sup.15 and R.sup.16 is aryl, arylalkyl, heterocyclo or heterocycloalkyl, or alkyl of 4 to 12 carbons; and/or(2) Q is other than ##STR471## (where R.sup.12 is CF.sub.3 ; and/or (3) where Q is ##STR472## and R.sup.12 is ##STR473## then heterocycle is a monocyclic or bicyclic heterocycle ring containing from 5 to 10 ring members, containing one to five nitrogen atoms, and/or one or two oxygen atoms, and/or one sulfur atom; and/or(4) where Q is ##STR474## and R.sup.12 is ##STR475## then at least one of R.sup.15 and R.sup.16 contains an amino group or R.sup.15 and R.sup.16 taken together with the nitrogen atom to which they are attached form a ring which contains an additional nitrogen atom in the ring and/or an amino group or an aminoalkyl group attached to the ring and/or(5) where Q is ##STR476## and R.sup.13 is ##STR477## then at least one of R.sup.15 and R.sup.16 contains an amino group or R.sup.15 and R.sup.16 taken together with the nitrogen atom to which they are attached form a ring which contains an additional nitrogen atom in the ring and/or an amino group or an aminoalkyl group attached to the ring.