Patent ID: 6528503
Filing Date: 2003-03-04
Classification: A61K,C07D,C07K

Abstract:
A compound of the general formula: or a pharmaceutically acceptable salt thereof, whereinR1 and R2 are independently selected from the group consisting of 1) hydrogen, 2) C1-6 alkyl, 3) C1-6 alkyl substituted with one, two or three members, same or different, selected from the group consisting of i) hydroxyl, ii) halogen, iii) CF3, iv) phenyl, v) phenyl, substituted with one, two or three members, same or different, selected from the group consisting of a) hydroxyl, b) halogen, c) CF3, d) C1-6 alkyl, e) C1-4 alkoxyl, f) amino, g) C1-4 alkylamino, and h) CH3C(O)NHâ€”, vi) pyridyl, vii) pyridyl substituted with one or two members, same or different, selected from the group consisting of a) halogen, b) C1-4 alkoxyl, and c) C1-6 alkyl, viii) pyridyl N-oxide ix) pyridyl N-oxide substituted with one or two members, same or different, selected from the group consisting of a) halogen, b) C1-4 alkoxyl, and c) C1-6 alkyl, x) C3-6 cycloalkyl, and xi) C3-6 cycloalkyl substituted with C1-4 alkyl or halogen, 4) Câ‰¡Câ€”R8, 5) phenyl, 6) phenyl substituted with one, two or three members, same or different, selected from the group consisting of i) hydroxyl, ii) halogen, iii) CF3, iv) C1-6 alkyl, v) C1-4 alkoxyl, vi) amino, vii) C1-4 alkylamino, and viii) CH3C(O)NHâ€”, 7) pyridyl, 8) pyridyl substituted with one or two members, same or different, selected from the group consisting of i) halogen, ii) C1-4 alkoxyl, and iii) C1-6 alkyl, 9) pyridyl N-oxide, 10) pyridyl N-oxide substituted with one or two members, same or different, selected from the group consisting of i) halogen, ii) C1-4 alkoxyl, and iii) C1-6 alkyl, 11) C3-6 cycloalkyl, and 12) C3-6 cycloalkyl substituted with C1-4 alkyl or halogen; R3 is hydrogen or halogen; R4 is halogen; R8 is selected from the group consisting of 1) hydrogen, 2) C1-6 alkyl, 3) C3-6 cycloalkyl, and 4) C3-6 cycloalkyl substituted with C1-4 alkyl or halogen, provided that when R3 is hydrogen, R4 is Cl, or a pharmaceutically acceptable salt thereof.