Patent ID: 6579869
Filing Date: 2003-06-17
Classification: A61P,C07D,Y02P

Abstract:
A compound selected from the group consisting of a compound of formula (I) wherein,W=O or NH, Q=COZâ€”R8, Z=O, S, or NH, and â€ƒwhen W represents O, the dotted line forms a double bond, R1 is null, R2 is H, R3 and R4 represent â€”Oâ€”CH2â€”Oâ€”, R5=OMe, Z=O, R=H, R6=â€”(Câ€”Y)Me2, Y=OH and n=3, or or Zâ€”R8 is NR12R13, R12 and R13 representing respectively R9 and R10, wherein R9 and R10 are independently H, unsubstituted C1-C30 alkyl, unsubstituted C3-C30 cycloalkyl, unsubstituted aryl, unsubstituted aryl-(C1-C30)-alkyl, unsubstituted C2-C30 alkenyl, unsubstituted C2-C30 alkynyl, unsubstituted C1-C30 trihalogenoalkyl, unsubstituted C1-C30 alkylamino-(C1-C30)alkyl, unsubstituted C1-C30 dialkylamino(C1-C30)-alkyl, or unsubstituted amino-(C1-C30)-alkyl, or where R14, R15 and R16 are independently H, halogen, unsubstituted C1-C30 alkyl, unsubstituted C3-C30 cycloalkyl, unsubstituted aryl, unsubstituted aryl-(C1-C30)-alkyl, unsubstituted C2-C30 alkenyl or unsubstituted C2-C30 alkynyl, unsubstituted C1-C30 trihalogenoalkyl, m is 0 to 4, and R11 is unsubstituted C2-C30 alkyl, unsubstituted C3-C30 cycloalkyl, unsubstituted aryl, unsubstituted aryl-(C1-C30)-alkyl, unsubstituted C2-C30 alkenyl, unsubstituted C2-C30 alkynyl, unsubstituted C1-C30 trihalogenoalkyl, unsubstituted C1-C30 alkylamino-(C1-C30)alkyl, unsubstituted C1-C30 dialkylamino(C1-C30)-alkyl, or unsubstituted amino-(C1-C30)-alkyl, or where R14, R15 and R16 are independently H, halogen, unsubstituted C1-C30 alkyl, unsubstituted C3-C30 cycloalkyl, unsubstituted aryl, unsubstituted aryl-(C1-C30)-alkyl, unsubstituted C2-C30 alkenyl or unsubstituted C2-C30 alkynyl, unsubstituted C1-C30 trihalogenoalkyl, m is 0 to 4, and wherein R11 may be CH3 when R9 and R10 are as stated above and Z represents S or NH and R9, R10 and R11 may simultaneously be H when Z represents S or NH and, R1 is H, OH, OMe, unsubstituted O-(C1-C30)-alkyl, unsubstituted O-aryl-(C1-C30)-alkyl, unsubstituted O-(C2-C30)-alkenyl, unsubstituted O-(C3-C30)-cycloalkyl or null, R2 is H or OH, or R1 and R2 form together â€”Oâ€”, R3=R4=OMe or R3 and R4 form together â€”OCH2Oâ€”, R is H, unsubstituted C1-C30alkyl or O-protecting group, R6=â€”(Câ€”Y)Me2, â€”CH&boxH;CMe2, or an unsubstituted aryl group or R and R6 form together â€”CMe2â€”, Y=H, OH or halogen, n is 0 to 8, R5 is H, OH, OMe, unsubstituted O-(C1-C30)-alkyl, unsubstituted O-aryl-(C1-C30)-alkyl, unsubstituted O-(C2-C30)-alkenyl, unsubstituted O-(C3-C30)-cycloalkyl or unsubstituted O-aryl, the dotted line is null or forms a double bond depending on the meaning of R1, and a compound according to the following formulae: