Patent ID: 6103907
Filing Date: 2000-08-15
Classification: A61P,C07C,C07D

Abstract:
Phenylalkylcarboxylic acid compounds of formula (I): ##STR8## wherein, R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms,R.sup.2 represents a straight- or branched-chain alkylene group having from 2 to 6 carbon atoms,R.sup.3 represents (i) a hydrogen atom, (ii) a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms, (iii) a straight- or branched-chain alkoxy group having from 1 to 4 carbon atoms, (iv) a straight- or branched-chain alkylthio group having from 1 to 4 carbon atoms, (v) a halogen atom, (vi) a nitro group, (vii) a straight- or branched-chain dialkylamino group in which alkyl groups are the same as or different from each other and each has from 1 to 4 carbon atoms, (viii) an aryl group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below, or (ix) an aralkyl group having from 7 to 12 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety,Z represents a single bond or a straight- or branched-chain alkylene group having from 1 to 6 carbon atoms,W represents (i) a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms, (ii) a hydroxyl group, (iii) a straight- or branched-chain alkoxy group having from 1 to 4 carbon atoms, (iv) a straight- or branched-chain alkylthio group having from 1 to 4 carbon atoms, (v) an amino group, (vi) a straight- or branched-chain monoalkylamino group having from 1 to 4 carbon atoms, (vii) a straight- or branched-chain dialkylamino group in which alkyl groups are the same as or different from each other and each has from 1 to 4 carbon atoms, (viii) an N-alkyl-N-arylamino group having a straight- or branched-chain alkyl having from 1 to 4 carbon atoms and an aryl having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below, (ix) an aryl group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below, (x) an aryloxy group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xi) an arylthio group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xii) an arylamino group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xiii) an aralkyl group having from 7 to 12 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xiv) an aralkyloxy group having from 7 to 12 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xv) an aralkylthio group having from 7 to 12 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xvi) an aralkylamino group having from 7 to 12 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below in the aryl moiety, (xvii) a 1-pyrrolyl group, (xviii) a 1-pyrrolidinyl group, (xix) a 1-imidazolyl group, (xx) a piperidino group or (xxi) a morpholino group,X represents an aryl group having from 6 to 10 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below, or a 5- to 10-membered monocyclic or bicyclic hetero aromatic group which is unsubstituted or substituted by 1 to 3 substituents .alpha. mentioned below containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms,the substituent .alpha. being (i) a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms, (ii) a straight- or branched-chain halogenated alkyl group having from 1 to 4 carbon atoms, (iii) a hydroxyl group, (iv) a straight- or branched-chain aliphatic acyloxy group having from 1 to 4 carbon atoms, (v) a straight- or branched-chain alkoxy group having from 1 to 4 carbon atoms, (vi) a straight- or branched-chain alkylenedioxy group having from 1 to 4 carbon atoms, (vii) an aralkyloxy group having from 7 to 12 carbon atoms, (viii) a straight- or branched-chain alkylthio group having from 1 to 4 carbon atoms, (ix) a straight- or branched-chain alkylsulfonyl group having from 1 to 4 carbon atoms, (x) a halogen atom, (xi) a nitro group, (xii) a straight- or branched-chain dialkylamino group in which alkyl groups are the same as or different from each other and each has from 1 to 4 carbon atoms, (xiii) an aralkyl group having from 7 to 12 carbon atoms, (xiv) an aryl group having from 6 to 10 carbon atoms (the aryl moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms, straight- or branched-chain halogenated alkyl having from 1 to 4 carbon atoms, straight- or branched-chain alkoxy having from 1 to 4 carbon atoms, halogen, or straight- or branched-chain alkylenedioxy having from 1 to 4 carbon atoms), (xv) an aryloxy group having from 6 to 10 carbon atoms (the aryl moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms, straight- or branched-chain halogenated alkyl having from 1 to 4 carbon atoms, straight- or branched-chain alkoxy having from 1 to 4 carbon atoms, halogen, or straight- or branched-chain alkylenedioxy having from 1 to 4 carbon atoms), (xvi) an arylthio group having from 6 to 10 carbon atoms (the aryl moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms, straight- or branched-chain halogenated alkyl having from 1 to 4 carbon atoms, straight- or branched-chain alkoxy having from 1 to 4 carbon atoms, halogen, or straight- or branched-chain alkylenedioxy having from 1 to 4 carbon atoms), (xvii) an arylsulfonyl group having from 6 to 10 carbon atoms (the aryl moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms, straight- or branched-chain halogenated alkyl having from 1 to 4 carbon atoms, straight- or branched-chain alkoxy having from 1 to 4 carbon atoms, halogen, or straight- or branched-chain alkylenedioxy having from 1 to 4 carbon atoms), (xviii) an arylsulfonylamino group having from 6 to 10 carbon atoms (the aryl moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms, straight- or branched-chair halogenated alkyl having from 1 to 4 carbon atoms, straight- or branched-chain alkoxy having from 1 to 4 carbon atoms, halogen or straight- or branched-chain alkylenedioxy having from 1 to 4 carbon atoms, and the nitrogen atom of the amino moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms), (xix) a 5- to 10-membered monocyclic or bicyclic hetero aromatic group containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms, (xx) a 5- to 10-membered monocyclic or bicyclic hetero aromatic oxy group containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms, (xxi) a 5- to 10-membered monocyclic or bicyclic hetero aromatic thio group containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms, (xxii) a 5- to 10-membered monocyclic or bicyclic hetero aromatic sulfonyl group containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms, or (xxiii) a 5- to 10-membered monocyclic or bicyclic hetero aromatic sulfonylamino group containing from 1 to 4 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur atoms (the nitrogen atom of the amino moiety is unsubstituted or substituted by straight- or branched-chain alkyl having from 1 to 6 carbon atoms), andY represents an oxygen atom, a sulfur atom or a group of the formula: >N--R.sup.4 (wherein R.sup.4 represents a hydrogen atom, a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms or a straight- or branched-chain aliphatic acyl group or aromatic acyl group having from 1 to 8 carbon), the pharmacologically acceptable salts thereof or the pharmacologically acceptable esters thereof.