Patent ID: 8603485
Filing Date: 2013-12-10
Classification: A61K,A61P,C07K

Abstract:
1. A method of administering a vaccine comprising at least one of a target antigen and a nucleic acid molecule encoding the target antigen to an individual in need thereof, the method comprising the step of: administering to the individual the vaccine and an agent that suppresses an immunosuppressive function of at least one immune regulatory cell-associated molecule selected from a cytokine and CTLA-4, wherein the agent is selected from the group consisting of a CTLA-4 antagonist, an IL-35 antagonist, a TGF beta antagonist, an IL-10 antagonist, an antagonistic anti-CTLA-4 antibody, an antagonistic anti-IL-35 antibody, an antagonistic anti-TGF beta antibody, and an antagonistic anti-IL-10 antibody, and wherein the individual is selected to receive the vaccine by a method comprising the steps of: