Patent ID: 6325937
Filing Date: 2001-12-04
Classification: B01D,B01J,G01N

Abstract:
In a fluidized bed chromatographic process for purification and binding of components in a liquid by binding said components to chromatographic beads derivitized to bind said components to said chromatographic beads in which process a fluidized bed of said chromatographic beads is formed and said liquid is passed through said fluidized bed, the improvement wherein:(a) said chromatographic beads are porous and comprise:(i) high density particles and(ii) a polymer matrix;(b) said polymer matrix is derivitized to bind said components to said chromatographic beads;(c) said high density particles are incorporated in said polymer matrix;(d) said chromatographic beads have a density of 1.10-1.50 g/ml when hydrated and a particle diameter of 100-1000 .mu.m; and(e) each of the density range and the particle diameter range of said chromatographic beads is selected to provide:(i) desired sedimentation properties of said chromatographic beads in said liquid in the fluidized bed chromatography process and(ii) a stabilized fluidized bed.