Patent ID: 7019133
Filing Date: 2006-03-28
Classification: C07D

Abstract:
1. A process for making mycophenolate mofetil comprising the steps of: A. conducting a transesterification by reacting an alkyl mycophenolate with 2-morpholinoethanol in the presence of an organic solvent and a catalyst selected from the group consisting of alkaline metal salt, alkaline earth metal salt, tin oxide and stannous oxide to produce crude mycophenolate mofetil; B. adding an acid aqueous solution into said crude mycophenolate mofetil to form an acid salt of mycophenolate mofetil to be soluble in the acid aqueous solution to be separated from the unreacted reactants insoluble in the acid aqueous solution; C. basifying the acid aqueous solution to be a base aqueous solution by adding a base therein; and D. extracting the mycophenolate mofetil from the base aqueous solution by an extracting organic solvent, and purifying the mycophenolate mofetil.