Patent ID: 6143929
Filing Date: 2000-11-07
Classification: C07C

Abstract:
A process for preparing guanidine derivatives of the formula I ##STR5## in which R.sup.1 is C.sub.1 -C.sub.8 -alkylene or a divalent cycloaliphatic radical with 5 to 10 carbon atomsR.sup.2 is H, C.sub.1 -C.sub.8 -alkyl, orR.sup.1 and R.sup.2 represent, together with the N atom to which they are bonded, a 5- or 6-membered Z-substituted ring,Z is COOR.sup.3.sub., SO.sub.2 OR.sup.3 or PO(OR.sup.3)(OR.sup.4),R.sup.3 is in each case independently H, an alkali metal or an equivalent of an alkaline earth metal andR.sup.4 is in each case independently H, an alkali metal, an equivalent of an alkaline earth metal or C.sub.1 -C.sub.6 -alkyl,which process comprises providing seed crystals of the guanidine derivative of the formula I and reacting an O-alkylisourea salt of the formula II ##STR6## in which R.sup.5 is C.sub.1 -C.sub.8 -alkyl and X.sup..crclbar. is an equivalent of an anion,with an amine of the formula III ##STR7## in the presence of the seed crystals.