Patent ID: 6335354
Filing Date: 2002-01-01
Classification: A61P,C07D

Abstract:
A compound having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein:R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, cycloalkyl, amino, aminoalkyl hydroxyalkyl, alkoxyalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfoniyl, carboxyalkyl, cyano, alkylamino, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, alkylcarbonyl, heterocyclocarbonyl, aminosulfdnyl, alkylaminostilfonyl, and heterocyclosulfonyl, all of which can be optionally substituted; R2 is hydrogen or C1-6 alkyl and R3 is hydrogen, or R2 and R3 together form a bond; R4 is hydrogen or C1-6 alkyl; R5, R6, R7, and R8 are independently selected from the (group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, aminoalkyl, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; X is one of O, S, NR9, or CH2, wherein R9 is hydrogen or alkyl; and m is 0-3.