Patent ID: 6903078
Filing Date: 2005-06-07
Classification: A61K,A61L,A61P,C07K

Abstract:
1. A method of repairing epithelial cell damage comprising applying directly to the site of epithelial cell damage a pharmaceutical composition comprising a first DNA molecule, a second DNA molecule, a third DNA molecule, and a fourth DNA molecule wherein the first DNA molecule comprises a first nucleotide sequence encoding PDGF, the second DNA molecule comprises a second nucleotide sequence encoding KGF, wherein the second DNA molecule further comprises a secretion leader encoding nucleotide sequence, where the secretion leader is sufficient for secretion of KGF, the third DNA molecule comprises a third nucleotide sequence encoding IGF, and the fourth DNA molecule comprises a fourth nucleotide sequence encoding an IGFBP, wherein the first, second, third and fourth nucleotide sequences are operably linked to control elements that provide for expression thereof at the site of epithelial cell damage.