Patent ID: 6018020
Filing Date: 2000-01-25
Classification: A01N,A61K,A61P,C07D,C07K

Abstract:
A compound of the formula ##STR23## wherein R.sup.1 is lower alkyl, halo-lower alkyl, cyano-lower alkyl, lower alkylthio-lower alkyl, aryl-lower alkylthio-lower alkyl, aryl-lower alkyl, heteroaryl-lower alkyl, lower alkenyl or lower alkynyl;R.sup.2 is lower alkyl, hydroxy-lower alkyl, carboxy-lower alkyl, aryl-lower alkyl, aminocarbonyl-lower alkyl or lower cycloalkyl-lower alkyl; andR.sup.3 is hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together are di- or trimethylene optionally substituted by hydroxy;R.sup.4 is lower alkyl, hydroxy-lower alkyl, lower cycloalkyl-lower alkyl, carboxy-lower alkyl, aryl-lower alkyl, lower alkylthio-lower alkyl, cyano-lower alkylthio-lower alkyl, aryl-lower alkylthio-lower alkyl, lower alkenyl, aryl or lower cycloalkyl;R.sup.5 is lower alkyl, hydroxy-lower alkyl, lower alkylthio-lower alkyl, aryl-lower alkyl, aryl-lower alkylthio-lower alkyl, cyano-lower alkylthio-lower alkyl or lower cycloalkyl;R.sup.6 is hydrogen or lower alkyl;R.sup.7 is lower alkyl, hydroxy-lower alkyl, carboxy-lower alkyl, aryl-lower alkyl, lower cycloalkyl-lower alkyl or lower cycloalkyl;R.sup.8 is lower alkyl, hydroxy-lower alkyl, carboxy-lower alkyl or aryl-lower alkyl; andR.sup.9 is lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl; andQ is ##STR24## wherein R.sup.12, R.sup.13, R.sup.14 and R.sup.15 each are hydrogen or lower alkyl and R.sup.16 and R.sup.17 each are hydrogen or lower alkyl, and wherein any carboxy, hydroxy or aminocarbonyl group present in the compound is or is not protected.