Patent ID: 6153750
Filing Date: 2000-11-28
Classification: C07D

Abstract:
A process for preparing (E)-methyl 2-[2-(6-(-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate comprising contacting (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate or methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropanoate with 2-cyanophenate anions in which said 2-cyanophenate anions are generated in situ by reacting 2-cyanophenol with an alkali metal carbonate, said process being conducted in the absence of copper or a copper salt and in the absence of N,N-dimethylformamide.