Patent ID: 8003315
Filing Date: 2011-08-23
Classification: A61P,C12Q,G01N

Abstract:
1. A method of identifying a candidate beta-catenin pathway modulating agent, said method comprising the steps of: (a) providing an in vitro cell-based assay system capable of detecting TAOJIK expression comprising mammalian cells in culture that express an endogenous and/or recombinant TAOJIK polypeptide comprising the amino acid sequence of SEQ ID NO:16, SEQ ID NO:17, or SEQ ID NO:18, wherein the cultured mammalian cells are living; (b) contacting the assay system with a candidate test agent; and (c) determining the expression of the TAOJIK in the assay system, wherein a change in TAOJIK expression between the presence and absence of said candidate test agent indicates that the candidate test agent is a candidate beta-catenin pathway modulating agent.