Patent ID: 8377864
Filing Date: 2013-02-19
Classification: A61K,A61L,A61P

Abstract:
1. A method for the controlled release of a platelet derived growth factor (PDGF) protein, said protein selected from the group consisting of PDGF-AB and PDGF-BB, in a patient in need thereof, comprising administering to a patient a fibrin sealant comprising PDGF, wherein at least 25% of the PDGF is retained in the fibrin sealant for at least 3 days, or wherein at least 20% of the PDGF is retained in the fibrin sealant for at least 10 days, wherein the fibrin sealant has a final fibrinogen complex concentration within the range of about 5 mg/ml to about 75 mg/ml.