Patent ID: 6025326
Filing Date: 2000-02-15
Classification: A61K,C07K

Abstract:
A method of treating or preventing oral mucositis in a subject, said method comprising the step of topically administering the oral cavity of said subject a therapeutically effective amount of an antimicrobial peptide selected from the group consisting of:(OM-3) RGGLCYCRGRFCVCVGR (SEQ ID NO:3); - (OM-4) RLLRACYCRXRFCVCVGR (X = MeGly) (SEQ ID NO:4); - (OM-6) RGGGLCYKRGWIKFCVGR (SEQ ID NO:6); - (OM-7) RGWGLCYCRPRFCVCVGR (SEQ ID NO:7); - (OM-8) RLCYCRPRFCVCVGR (SEQ ID NO:8); - (OM-10) LCYCRGRFCVCVGR (SEQ ID NO:10); - (OM-11) RWRLCYCRPRFCVCV (SEQ ID NO:11); - (OM-12) RGWRLCYCRPRFCVCVGR (SEQ ID NO:12); - (OM-13) RGWRACYCRPRFCACVGR (SEQ ID NO:13); - (OM-14) GWRLCYCRPRFCVCVGR (SEQ ID NO:14); - (OM-15) XCYCRRRFCVCV (X = Cha) (SEQ ID NO:15); - (OM-16) WLXYXRRRFCVCV* (SEQ ID NO:16); - (OM-17) RLCYCRXRFCVCV (X = MeGly) (SEQ ID NO:17); - (OM-18) RLCYCRPRFCVCVGR* (SEQ ID NO:18); - (OM-20) RXCFCRPRFCVCV (X = Cha) (SEQ ID NO:20); - (OM-21) RWCFCRPRFCVCV (SEQ ID NO:21); - (OM-22) LCXCRRRXCVCV (X = Cha) (SEQ ID NO:22); - (OM-23) RGGRLCYCRRRFCVC (SEQ ID NO:23); - (OM-24) LCYTRRRFTVCV (SEQ ID NO:24); - (OM-25) RRCYCRRRFCVCVGR (SEQ ID NO:25); - (OM-26) RKCTCRRRFCVCV* (SEQ ID NO:26); - (OM-27) RXRLCYCRZRFCVCV (X = Cha) (SEQ ID NO:27); (Z = MeGly) - (OM-28) RGWRLCYCRGRXCVCV (X = Cha) (SEQ ID NO:28); - (OM-29) RGLRXCYCRGRFCVCVGR (X = Cha) (SEQ ID NO:29); - (OM-30) RGWRGCYKRGRFKGCVGR (SEQ ID NO:30); - (OM-31) RGWRGCYCRXRFCGC (X = MeGly) (SEQ ID NO:31); - (OM-32) RGGLCYCRGRFCVCVGR (SEQ ID NO:32); - (OM-33) RLLRLCYCRXRFCVCVGR (X = MeGly) (SEQ ID NO:33); - (OM-35) RGWRLCYCRGRFCVCVGR (SEQ ID NO:35); - (OM-40) WLXYXRRRFCVCV (SEQ ID NO:40); - (OM-41) RGGGLCYARGWIAFCVCVGR (SEQ ID NO:41); - (OM-42) LCYCRRRFCVCVF (SEQ ID NO:42); - (OM-43) RLCYCRPRFCVCV (SEQ ID NO:43); and - (OM-44) RLCACRGRACVCV (SEQ ID NO:44), wherein peptides denoted with .sup.* are acid forms and all others are amide forms.