Patent ID: 8852620
Filing Date: 2014-10-07
Classification: A61L,C08F

Abstract:
1. A medical device comprising a controlled-release drug delivery system comprising: a drug admixed with a polymer, said polymer comprising monomers arranged in a directional gradient of different hydrophobic and/or hydrophilic monomers throughout the polymer; wherein the directional gradient forms a drug solubility gradient that is continuous throughout the polymer from a region of high relative hydrophobicity to a region of high relative hydrophilicity; and wherein the polymer is prepared by a method comprising: preparing a first monomeric charge solution comprising at least one monomer; preparing at least one additional monomeric charge solution comprising at least one monomer; contemporaneously initiating polymerization of the at least one monomer of the first monomeric charge solution while adding the additional monomeric charge solution.