Patent ID: 6358921
Filing Date: 2002-03-19
Classification: A61K,C07K,Y02A

Abstract:
A 14-mer cyclic peptide having an amino acid substitution in the amino acid sequence V1-K2-L3-K4-V5-Y6-P7-L8-K9-V10-K11-L12-Y13-P14 also identified by SEQ ID NO: 1, where Y represents D-tyrosine, numerals represent relative positions in said peptide, P14 is linked to V1, and said amino acid substitution is a D-amino acid in at least one of positions 1-5, 7-12 and 14, or an L-amino acid in position 6 or 13, and further characterized by a therapeutic index of greater than 1, wherein said therapeutic index value is determined as a ratio of the concentration of peptide required to produce hemolysis of human red blood cells divided by the concentration of peptide required to inhibit growth of a specified microorganism.