Patent ID: 8716342
Filing Date: 2014-05-06
Classification: A61K,A61P,B82Y,C07C

Abstract:
1. A method for preparing a soluble molecular complex comprising adapalene or a salt thereof included in randomly methylated β-cyclodextrin (RAMEB), the method comprising the following steps: (a) bringing adapalene into contact with RAMEB to form a mixture, (b) carrying out a molecular diffusion step by bringing a dense fluid under pressure into contact, in static mode, with the mixture obtained in step (a), in the presence of a diffusion agent comprising water to afford an aqueous mixture, and (c) recovering the molecular complex from the aqueous mixture thus formed, said molecular complex having a molar ratio of adapalene to RAMEB of from 1:2 to 1:10; followed by (b′) dissolving the molecular complex in water to form an aqueous solution thereof and then adding to said aqueous solution free RAMEB in excess to the amount of RAMEB in the molecular complex, in an amount which stabilizes the molecular complex in the aqueous solution.