Patent ID: 6228400
Filing Date: 2001-05-08
Classification: A61K,A61P

Abstract:
An orally administered pharmaceutical granule comprising:an inert core comprising at least one compound and/or mixture selected from the group consisting of starch, a mixture of sugar and starch, and microcrystalline cellulose;a drug emulsion deposited on said inert core, wherein said drug emulsion comprises an effective amount of a free base omeprazole or a free base lansoprazole, a non-ionic surfactant, a basic amino acid, and water;a protective coating deposited on said drug emulsion, wherein said protective coating comprises at least one film-forming compound which is selected from the group consisting of hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), polyvinyl pyrrolidone (PVP) and hydroxy methylcellulose (HMC), and a plasticizer; andan enteric coating deposited on said protective coating, wherein said enteric coating comprises at least a polymer which is selected from the group consisting of hydroxypropyl methylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), and co-polymerized methacrylic acid/methacrylic acid methyl esters, and a plasticizer,wherein said plasticizer is one compound selected from the group consisting of triethyl citrate, triacetin, and diethyl phthalate.