Patent ID: 6512001
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A D-proline compound of the formula: whereinR1 is hydrogen or halogen; X is â€”(CH2)nâ€”; â€”CH(R2)(CH2)nâ€”; â€”CH2O(CH2)nâ€”; â€”CH2NHâ€”; benzyl; â€”C(R2)&boxH;CHâ€”; â€”CH2CH(OH)â€”; or thiazol-2,5-diyl; Y is 2,5-furanyl or 2,5-thienyl; Xâ€² is â€”(CH2)nâ€”; â€”(CH2)nCH(R2)â€”; â€”(CH2)nOCH2â€”; â€”NHCH2â€”; benzyl; â€”CH&boxH;C(R2)â€”; â€”CH(OH)CH2â€”; or thiazol-2,5-diyl; R2 is lower alkyl, lower alkoxy, or benzyl;  is a single or a double bond; and n is 0-3, or a pharmaceutically acceptable salt, monoester, or diester thereof.