Patent ID: 6809102
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound of formula I its enantiomers, diastereomers, or pharmaceutically acceptable salts, and solvates thereof, whereinR1 is selected from the group consisting of hydrogen, alkyl and cycloalkyl; R2 is aryl, or heteroaryl; R3 is H; R4 is selected from the group consisting of alkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, heterocycloalkyl, aminoalkyl, heterocycloalkylalkyl, CN, C(O)R5, CO2R5, C(O)SR5 and CONR5R6; R5 and R6 are each independently selected from the group consisting of H, alkyl, cycloalkyl, hydroxyalkyl, alkenyl, alkoxy, thioalkoxy, alkoxyalkyl, haloalkyl, aryl, heteroaryl, arylalkyl, cycloalkylalkyl, heteroarylalkyl and heterocycloalkylalkyl or Nâ€”R5R6 together form a heterocycloalkyl Z is selected from the group consisting of O, S and NR6; R8 is selected from the group consisting of H, CN, sulfonamido, OR7, alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl and heteroarylalkyl; and R7 is selected from the group consisting of H, alkyl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl and heteroarylalkyl.