Patent ID: 6562375
Filing Date: 2003-05-13
Classification: A61K

Abstract:
A stable hydrogel-forming pharmaceutical composition for oral use comprising:a yellow ferric oxide and/or a red ferric oxide in an amount effective to stabilize a matrix sustained-release preparation containing (a) a drug, (b) 5 to 80 wt % of hydrophilic base having a solubility that the amount of water needed to dissolve 1 g of said hydrophilic base is 5 ml or less at 20Â±5Â° C., and (c) 10 to 95 wt % of polyethylene oxide (i) having a viscosity of 2,000 cP or higher as an aqueous 2% solution at 25Â° C. or (ii) having a viscosity-average molecular weight of 2,000,000 or higher, wherein said matrix preparation contains polyethylene oxide as a base of a sustained-release preparation, wherein said drug and said hydrophilic base are dispersed in a polyethylene oxide, and wherein said amount of yellow ferric oxide is 1 to 20 wt % or red ferric oxide is 3 to 20 wt %, with physical mixing in the matrix per preparation weight, or said amount of yellow ferric oxide and/or red ferric oxide is 0.3 to 2 wt %, in film coating per tablet weight.