Patent ID: 7547445
Filing Date: 2009-06-16
Classification: A61L,Y10S

Abstract:
1. A method of reducing immediate and chronic adverse reactions to an implanted medical device, comprising: providing a medical device, providing a matrix-forming system comprising a multifunctional polymerization initiator and a crosslinikable macromer comprising one or more polymer backbones having pendent polymerizable groups, implanting the medical device within a tissue site with the matrix-forming system positioned between the medical device and the tissue, and polymerizing the matrix-forming system to form a crosslinked matrix between the medical device and the tissue, wherein the multifunctional polymerization initiator is a non-polymer bound initiator and comprises a non-polymeric core with pendent chemical molecules that are capable of initiating a free radical reaction and pendent chemical molecules capable of reducing immediate and chronic adverse reactions to the medical device.