Patent ID: 6011181
Filing Date: 2000-01-04
Classification: C07B,C07C,C07D

Abstract:
A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide in a mixture comprising a desired product and at least one such oxide, said process comprisinga) the addition of a metal salt to form a complex or complexes with the tri-substituted phosphine, arsine or stibine oxide or oxides, andb) the separation of the resultant complex or complexes from the remainder of the mixture,with the proviso that when the mixture is the result of a Mitsunobu reaction, and one of the starting materials of said reaction is a compound of formula A, then the other starting material is other than a compound of formula B, such compounds being defined as follows: ##STR2## in which R.sub.1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C.sub.1-6 alkyl, C.sub.1-6 alkoxy or C.sub.1-6 alkanoyl;R.sub.2 and R.sub.3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkanoyl, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulphinyl or C.sub.1-6 alkylsulphonyl;R.sub.4 and R.sub.5 independently represent H, C.sub.1-6 alkyl or R.sub.4 and R.sub.5 combined together with the carbon atom to which they are attached represent C.sub.3-6 cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C.sub.1-6 alkyl) andR.sub.6, R.sub.7 and R.sub.8 independently represent H, halo, hydroxy, mercapto, nitro, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C.sub.1-6 alkyl): C.sub.1-6 alkyl, C.sub.1-6 alkanoyl, C.sub.1-6 alkoxy, C.sub.2-6 alkoxycarbonyl, carboxy, C.sub.1-6 alkanoyloxy, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkyl-sulphonylamino, sulphamoyl, carbamoyl, C.sub.2-6 alkyl-carbamoyl or C.sub.1-6 alkanoylamino.