Patent ID: 8785121
Filing Date: 2014-07-22
Classification: A61K,A61P,C12N

Abstract:
1. A single-stranded nucleic acid molecule comprising: an expression inhibitory sequence that inhibits expression of a target gene, wherein the single-stranded nucleic acid molecule comprises, in sequence from a 5′ side to a 3′ side: a 5′ side region (Xc); a linker region (Lx); an inner 5′ side region (X); an inner 3′ side region (Y); a linker region (Ly); and a 3′ side region (Yc), the 5′ end and the 3′ end of the single-stranded nucleic acid molecule are not linked to each other, the 5′ side region (Xc) and the inner 5′ side region (X) are linked to each other by the linker region (Lx), wherein the 5′ side region (Xc) has 1 to 29 bases, the 3′ side region (Yc) and the inner 3′ side region (Y) are linked to each other by the linker region (Ly), wherein the 3′ side region (Yc) has 1 to 29 bases, a inner region (Z) consists of the inner 5′ side region (X) and the inner 3′ side region (Y) that are linked to each other, and has 19 to 30 bases, the 5′ side region (Xc) is complementary to the inner 5′ side region (X), the 3′ side region (Yc) is complementary to the inner 3′ side region (Y), and the inner region (Z), comprises the expression inhibitory sequence, and the expression inhibitory sequence is a ribonucleic acid (RNA) molecule.