Patent ID: 6228889
Filing Date: 2001-05-08
Classification: A61K,A61P

Abstract:
A method for determining the therapeutic capacity of a GalT-2 inhibitor compound to reduce restenosis in a mammal, comprising:performing an invasive surgical procedure on the mammal;administering a GalT-2 inhibitor compound to the mammal; andexamining a vessel of the mammal for restenosis;wherein the GalT-2 inhibitor compound is represented by Formula I: ##STR3##wherein R and R.sup.1 are independently selected from the group consisting of hydrogen and straight-chained or branched C.sub.1 -C.sub.6 alkyl with or without a substituent, and further wherein R and R.sup.1 may be taken together to form a 5, 6 or 7-membered ring,R.sup.2 is selected from the group consisting of branched or straight-chained C.sub.6 -C.sub.30 alkyl with or without one to three double bonds, and R.sup.3 is selected from the group consisting of straight-chained or branched C.sub.6 -C.sub.20 alkyl with or without one to three double bonds and aryl or substituted aryl, where the substituent is halo, C.sub.1 -C.sub.4 alkoxy, methylenedioxy, C.sub.1 -C.sub.4 mercapto, amino or substituted amino in which the amino substituents may suitably be C.sub.1 -C.sub.4 alkyl.