Patent ID: 8618119
Filing Date: 2013-12-31
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) in which ring Q represents a group of the formula where * represents in each case the point of attachment to the C2 atom, # represents in each case the point of attachment to the C3 atom, R R R R in which (C R in which (C i) R in which (C and R or R and R and R in which (C X represents S or O, R where (C in which phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, nitro, cyano, (C R where (C in which (C in which (C and where 5- or 6-membered heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of oxo, thioxo, hydroxyl, (C in which (C in which (C and in which (C and in which (C and where phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, hydroxyl, (C in which (C and in which (C and in which (C and in which R in which (C R in which (C and in which (C or in which two adjacent substituents at the phenyl together with the carbon atoms to which they are attached may form a 1,3-dioxolane or 2,2-difluoro-1,3-dioxolane, or an N-oxide, salt, or salt of the N-oxide thereof, except for the compounds 5,6,7,8-tetrahydro-2-[[(2-methylphenyl)methyl]thio]-4-(2-thienyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(2-phenylmethyl)thio]-4-(2-thienyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[[(2-methylphenyl)methyl]thio]-4-(4-pyridyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(phenylmethyl)thio]-4-phenyl-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(phenylmethyl)thio]-4-(4-chlorophenyl)-3-quinolinecarbonitrile, 6,7-dihydro-4-(4-hydroxyphenyl)-2-[(phenylmethyl)thio]-5H-cyclopentapyridine-3-carbonitrile.