Patent ID: 7081489
Filing Date: 2006-07-25
Classification: B01J

Abstract:
1. A method of making polymeric nanoparticles comprising: providing active agent nanoparticles having an average diameter between about 5 and about 100 nm; treating said active agent nanoparticles with an anionic surfactant to form modified active agent nanoparticles: mixing the modified active agent nanoparticles with a solution of a polymer in a solvent at a first temperature, which is greater than the melting temperature of the polymer and less than the boiling point of the solvent to form a first mixture, said mixing comprising the use of sonication; mixing a non-solvent with the first mixture to form a second mixture, the non-solvent being non-solvent for the solvent and for the polymer and having a boiling point greater than the melting temperature of the polymer; sonicating the second mixture to form an emulsion; and cooling the emulsion to a second temperature and at a rate effective to precipitate polymeric nanoparticles comprising the polymer with the modified active agent nanoparticles dispersed therein.