Patent ID: 7348341
Filing Date: 2008-03-25
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: m and n are, independently, 0, 1, 2, 3 or 4; X is O; Y is NR 4 S(O) 2 R 5 or S(O) 2 NR 4 R 5 ; T is C═O or CR 7 R 8 ; R 1 is hydrogen, C 1-6 alkyl, aryl or heterocyclyl; R 2 and R 3 are, independently, hydrogen or C 1-6 alkyl; R 4 and R 6 are, independently, hydrogen or C 1-6 alkyl (optionally substituted with aryl); R 5 is C 1-6 alkyl {optionally substituted by halogen, CO 2 R 11 , aryl or heterocyclyl}, C 3-10 cycloalkyl {optionally substituted by C 1-4 alkyl or oxo}, C 3-7 cycloalkenyl {optionally substituted by C 1-6 alkyl or aryl}, aryl or heterocyclyl; or, when Y is S(O) 2 NR 4 R 5 , R 5 may also be hydrogen; R 7 , R 8 , R 9 and R 10 are, independently, hydrogen or C 1-6 alkyl (optionally substituted with aryl); wherein the foregoing aryl and heterocyclyl moieties are, independently, optionally substituted by one or more of halo, cyano, nitro, hydroxy, S(O) q R 11 , OCONR 12 R 13 , NR 14 R 15 , NR 16 COR 17 , NR 18 CONR 19 R 20 , SO 2 NR 21 R 22 , NR 23 SO 2 R 24 , CONR 25 R 26 , COR 27 , CO 2 R 28 , OCOR 29 , NR 30 CO 2 R 31 , C 1-6 alkyl (itself optionally substituted with halo, C 1-6 alkoxy, C 3-10 cycloalkyl, CO 2 (C 1-6 alkyl), OCO(C 1-6 alkyl), SO 2 R 32 , CONR 33 R 34 , phenyl, phenoxy, heterocyclyl or heterocyclyloxy), C 3-10 cycloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 2-6 alkenyl, C 2-6 alkynyl, methylenedioxy, phenyl, phenoxy, phenylthio, phenyl(C 1-4 )alkoxy, heterocyclyl, heterocyclyloxy or heterocyclyl(C 1-4 )alkoxy; wherein any of the immediately foregoing phenyl and heterocyclyl moieties are optionally substituted with halo, hydroxy, nitro, S(O) k C 1-4 alkyl, SO 2 NH 2 , cyano, C 1-4 alkyl, C 1-4 alkoxy, CONH 2 , CONH(C 1-4 alkyl), CO 2 H, CO 2 (C 1-4 alkyl), NHCO(C 1-4 alkyl), NHSO 2 (C 1-4 alkyl), CO(C 1-4 alkyl), CF 3 or OCF 3 ; R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 , R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 33 and R 34 are, independently, hydrogen, C 1-6 alkyl or aryl (itself optionally substituted by halo, C 1-6 alkyl, C 1-6 haloalkyl, CN, NO 2 , C 1-6 alkoxy or C 1-6 haloalkoxy); R 11 , R 24 and R 32 are, independently, C 1-6 alkyl or aryl (itself optionally substituted by halo, C 1-6 alkyl, C 1-6 haloalkyl, CN, NO 2 , C 1-6 alkoxy or C 1-6 haloalkoxy); k and q are, independently, 0, 1 or 2; or a pharmaceutically acceptable salt thereof.