Patent ID: 8927707
Filing Date: 2015-01-06
Classification: C07D

Abstract:
1. A process for refining Aztreonam comprising the following steps: 1) treating a crude Aztreonam with an alkali metal alkoxylate or an alkali earth metal alkoxylate with heat in a suitable solvent or a mixture of solvents, then adjusting pH with a suitable acid and cooling to precipitate Aztreonam which yields a primary purified Aztreonam; 2) loading the primary purified Aztreonam into a strongly basic ion exchange resin, then eluting the resin and collecting eluate which is concentrated by a reduced pressure to yield a secondary purified Aztreonam; and 3) adjusting pH value with a suitable acid to allow crystallization, then centrifuging, washing and drying the resultant crystals to yield a tertiary purified Aztreonam.