Patent ID: 7125869
Filing Date: 2006-10-24
Classification: A61P,C07C,C07D

Abstract:
1. A polycyclic compound having the structural formula (I): in which R 1 is a radical selected from among those of the following formulae (a)–(c): wherein R 4 , R 5 , V, W and Y are as defined below; R wherein R 6 , R 14 , R′, R″ and n are as defined below; R′ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, a hydroxyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R″ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a radical —(CH 2 ) n —R 6 , wherein R 6 and n are as defined below; R 6 is an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a radical NH—CO—R 7 , a radical NH—CO—O—R 7 or a radical N—R 7 R 8 , wherein R 7 and R 8 are as defined below; n has the values 1, 2 or 3; R 7 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R 8 is a hydrogen atom or an alkyl radical having from 1 to 3 carbon atoms; X is an oxygen or sulfur atom, or a methylene (CH 2 ) or NR 9 radical, wherein R 9 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms or an aralkyl radical; A is a linking radical having the following structure: or wherein D, r, g, p and m are as defined below and R 10 is also as defined below; D is an oxygen or sulfur atom, a radical NR 11 , or a CH 2 radical, wherein R 11 is as defined below; m, p, q and r, which may be identical or different, each has the values 0 or 1; R 10 and R 11 , which may be identical or different, are each a hydrogen atom or an alkyl radical having from 1 to 12 carbon atoms; V is an oxygen, sulfur or nitrogen atom, the nitrogen atom being bonded to a hydrogen atom or an alkyl radical having from 1 to 6 carbon atoms; W is a nitrogen atom or a radical C—R 12 , wherein R 12 is as defined below; Y is a nitrogen atom or a carbon atom; R 12 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R 13 is a hydrogen or halogen atom; R 14 is a heterocyclic radical; R 15 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; t, u and z, which may be identical or different, each has a value from 0 to 4; R 16 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a radical NHCOR 7 , a radical NHCOOR 7 or a radical NR 7 R 8 , wherein R 7 and R 8 are as defined above, with the proviso that, when m is 0, then q is 1 and R 10 is an alkyl radical having from 1 to 12 carbon atoms; and the optical and geometrical isomers and salts thereof.