Patent ID: 7563865
Filing Date: 2009-07-21
Classification: B01J,C07K

Abstract:
1. A process for accelerating the solid phase synthesis of peptides, and comprising: deprotecting the alpha-amino group of a first amino acid protected with a composition selected from the group consisting of Na-9-fluorenylmethyloxycarbonyl (Fmoc) and Na-t-butoxycarbonyl (Boc) and linked to solid phase resin particles by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves; activating a second amino acid by adding the second acid and an activating solution to the same vessel; coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves; and successively deprotecting, activating, and coupling a plurality of amino acids into a peptide in the same microwave transparent vessel without removing the peptide from the same vessel between cycles.