Patent ID: 6610708
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A cyclic amino compound represented by the following formula: wherein:R1 represents a phenyl group which may optionally be substituted by at least one substituent selected from the group consisting of halogen atoms, C1-C4 alkyl groups, fluoro-substituted-(C1-C4 alkyl) groups, C1-C4 alkoxy groups, fluoro-substituted- (C1-C4 alkoxy) groups, cyano groups and nitro groups; R2 represents a substituent selected from the group consisting of C1-C8 aliphatic acyl groups which may optionally be substituted by at least one substituent selected from the group consisting of halogen atoms, C1-C4 alkoxy groups and cyano groups, benzoyl groups which may optionally be substituted by at least one substituent selected from the group consisting of halogen atoms, C1-C4 groups and C1-C4 alkoxy groups, and (C1-C4 alkoxy) carbonyl groups; and R3 represents a saturated cyclic amino group having five carbon atoms and one ring nitrogen atom, said saturated cyclic amino group being substituted by a group having the formula â€”Sâ€”Xâ€” R4 wherein R4 and X are as defined below, said saturated cyclic amino group being attached via the ring nitrogen atom thereof to the carbon atom to which substitutents R1 and R2 are attached, R4 represents a substituent selected from the group consisting of phenyl groups which may optionally be substituted by at least one substituent selected from the group consisting of halogen atoms, C1-C4 alkyl groups, C1-C4 alkoxy groups, nitro groups and cyano groups, C1-C4 alkyl groups which may optionally be substituted by at least one substituent selected from the group consisting of amino groups, hydroxyl groups, carboxyl groups, (C1-C4 alkoxy) carbonyl groups, substituents having the formula â€”NHâ€”A1, wherein A1 represents an &agr;-amino acid residue, and substituents having the formula â€”COâ€”A2, wherein A2 represents an &agr;-amino acid residue, and C3-C8 cycloalkyl groups; and X represents a sulfur atom, a sulfinyl group or a sulfonyl group; said cyclic amino group may optionally be further substituted by a group having the formula =CR5R6, wherein R5 and R6 are the same or different and each is independently selected from the group consisting of hydrogen atoms, C1-C4 alkyl groups, carboxyl groups, (C1-C4 alkoxy) carbonyl groups, carbamoyl groups, (C1-C4 alkyl) carbamoyl groups and di- (C1-C4 alkyl) carbamoyl groups; or a pharmacologically acceptable salt thereof.