Patent ID: 6329402
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A heterocycle-containing carboxylic acid derivative represented by the formula (I): ##STR246##wherein A is a group represented by the following formula ##STR247##in which E.sup.3, F.sup.3 and G.sup.3 are the same or different and each independently represents an oxygen atom or a nitrogen, carbon or sulfur atom which may have a substituent with the proviso where in the ring (iii), E.sup.3, F.sup.3 and G.sup.3 each represents a carbon group which may have a substituent are excluded; R.sup.1 and R.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, a lower alkoxy group which may have a substituent, a cycloalkyloxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an aryloxy group which may have a substituent, a heteroaryloxy group which may have a substituent, a cycloalkylalkyl group which may have a substituent, an arylalkyl group which may have a substituent, a heteroarylalkyl group which may have a substituent, a cycloalkylalkyloxy group which have a substituent, an arylalkyloxy group which may have a substituent, a heteroarylalkyloxy group which may have a substituent, an alkenyl group which may have a substituent or an alkynyl group which may have a substituent, or R.sup.1 and R.sup.2 are coupled together to form a cycloalkylene group may have a substituent, a carbon group forming said cycloalkylene group which may be substituted by a sulfur atom, an oxygen atom, a sulfinyl group, a sulfonyl group or >NR.sup.4, R.sup.4 representing a hydrogen atom or a lower alkyl group;B is a heteroarylene group which may have a substituent, an arylene group which may have a substituent, or a group represented by the following formula: ##STR248##wherein R.sup.5 represents a hydrogen atom or a lower alkyl group; R.sup.6 and R.sup.7 are the same or different and each independently represents a hydrogen atom, a lower alkyl group or a halogen atom and m1 stands for 1 to 3, m.sub.2 stands for 0 to 2; R.sup.8 to R.sup.15 are the same or different and each independently represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom, a sulfur atom or >NR.sup.4, R.sup.4 having the same meaning as defined above;D is an arylene group which may have a substituent, a heteroarylene group which may have a substituent, or a group represented by the formula: --CR.sup.6.dbd.CR.sup.7 --, R.sup.6 and R.sup.7 having the same meanings as defined above;n.sub.1 stands for 0 to 1;M is a hydroxyl group, a lower alkoxy group or a group represented by the following formula: --NR.sup.16 R.sup.17 in which R.sup.16 and R.sup.17 are the same or different and each independently represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a hydroxyalkyl group, an aryl group or a heteroaryl group or R.sup.16 and R.sup.17 are coupled together with the adjacent nitrogen atom to form an oxygen- or sulfur-containing ring; and{character pullout} represents a single bond or double bond; or a physiologically acceptable salt thereofprovided that when B is CONH or NHCO and M is a hydroxyl group, n.sub.1 is O or D is --CR.sup.6.dbd.CR.sup.7 --, and further provided that when B is CONH or NCHO and M is a lower alkoxy group or a group of the formula NR.sup.16 R.sup.17, n.sub.1 is 0 or D is --CR.sup.6.dbd.CR.sup.7 --.