Patent ID: 6110910
Filing Date: 2000-08-29
Classification: A61P,C07D

Abstract:
A compound of Formula 3 or 4: ##STR27## or a pharmaceutically acceptable salt form thereof, wherein: R.sup.1 and R.sup.2 are independently H, F, Cl, Br, CF.sub.3, or alkyl of 1-4 carbons;R.sup.3 is selected from: phenyl, phenoxy, phenylthio, phenylsulfinyl, phenyl-N(R.sup.4)--, furyl, thienyl, pyridyl, thiazolyl, or oxazolyl; wherein said phenyl, phenoxy, phenylthio, phenylsulfinyl, phenyl-N(R.sup.4)--, furyl, thienyl, pyridyl, thiazolyl, or oxazolyl is substituted with 0-2 groups independently selected from: F, Cl, Br, CF.sub.3, alkyl of 1-4 carbons, alkoxy of 1-4 carbons, alkylthio of 1-4 carbons or alkylsulfinyl of 1-4 carbons;R.sup.4 is H, alkyl of 1-4 carbons or acyl of 1-4 carbons;X is --Y--, --CH.sub.2 Y--, --YCH.sub.2 --, --CH.sub.2 CH.sub.2 Y--, --YCH.sub.2 CH.sub.2 --, --CH.sub.2 YCH.sub.2 --, --CR.sup.5 =C(R.sup.6)--, --CR.sup.6 =N--, or --N=C(R.sup.6)-- (the first atom of X as listed being attached to the quinoline ring); wherein each methylene group in X may be optionally substituted with one or two groups independently selected from alkyl of 1-4 carbons;Y is --CH.sub.2 -- (said --CH.sub.2 -- being optionally and independently substituted with one or two alkyl groups of 1-4 carbons), --O--, --S--, or --N(R.sup.7)--;R.sup.5 and R.sup.6 are independently H or alkyl of 1-4 carbons;R.sup.7 is H, alkyl of 1-4 carbons, or acyl of 1-4 carbons;wherein, in compounds of Formula 3:one of Q.sup.1 and Q.sup.2 is NR.sup.9 and the other is CR.sup.10 or N, provided that the ring which contains Q.sup.1 and Q.sup.2 contains an additional double bond placed so as to generate an aromatic ring;R.sup.9 is H or alkyl of 1-4 carbons;R.sup.10 is H, F, Cl, Br, CF.sub.3, or alkyl of 1-4 carbons;wherein, in compounds of Formula 4:one of Q.sup.3 and Q.sup.4 is N and the other is C, provided that the ring of Formula 4 which contains Q.sup.3 and Q.sup.4 contains an additional double bond placed so as to generate an aromatic pyrrole ring; andR .sup.11 is H, F, Cl, Br, CF.sub.3, or alkyl of 1-4 carbons;subject to the following provisos:1) X is not NR.sup.7 ;3) in compounds of Formula 3, or of Formula 4 where Q.sup.4 is N, X must form a bridge of at least two atoms, and the atom of X attached to the ring containing Q.sup.1 and Q.sup.2 or Q.sup.3 and Q.sup.4 must be carbon;4) in compounds of Formula 4 where Q.sup.3 is N, X must consist of either --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 --, with each methylene group of X optionally and independently substituted as described above; and5) in compounds of Formula 4 where Q.sup.4 is N, then R.sup.3 must not be phenoxy, phenylthio, phenylsulfinyl, or phenyl-N(R.sup.4)--.