Patent ID: 6699858
Filing Date: 2004-03-02
Classification: A61P,C07D

Abstract:
A compound of formula a N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein:n is zero, 1, 2, 3, 4, 5 or 6; X is CH2 or O; R1 and R2 each independently are hydrogen, C1-6alkyl, C1-6alkylcarbonyl, halomethylcarbonyl or C1-6alkyl substituted with hydroxy, C1-6alkyloxy, carboxyl, C1-6alkylcarbonyloxy, C1-6alkyloxycarbonyl or aryl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or a radical of formula: wherein:R9, R10, R11 and R12 each independently are hydrogen, halo, halomethyl or C1-6alkyl; m is zero, 1, 2, or 3; R13, R14, R15 and R16 each independently are hydrogen, C1-6alkyl, aryl or arylcarbonyl; or R15 and R16 taken together may form a bivalent radical C4-5alkanediyl; R17 is hydrogen, C1-6alkyl, C1-6alkylcarbonyl, halomethylcarbonyl, C1-6alkyloxycarbonyl, aryl, di(aryl)methyl or C1-6alkyl substituted with hydroxy, C1-6alkyloxy, carboxyl, C1-6alkylcarbonyloxy, C1-6alkyloxycarbonyl or aryl; R3 and R4 are both halogen; or R3 is halogen and R4 is hydrogen; or R3 is hydrogen and R4 and halogen; and aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents selected from halo, hydroxy, C1-6alkyl and halomethyl.