Patent ID: 6821986
Filing Date: 2004-11-23
Classification: A61P,C07C,C07D

Abstract:
A compound of formula wherein R1 is hydrogen or alkyl;one of A and Aâ€² is and the other is hydrogen, R28 is selected from the group consisting of hydrogen, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl and aralkyl with the aryl unsubstituted or substituted by at least one, member selected from the group consisting of â€”OH, halogen, alkyl, alkoxy, nitro and â€”NR29R30, R29 and R30 are individually selected from the group consisting of hydrogen, alkyl, and â€”COR31 or R29 and R30 together with the nitrogen form an unsubstituted or substituted heterocycle of 4 to 7 ring members and 1 to 3 heteroatoms selected from the group consisting of N, O and S, R31 is selected from the group consisting of hydrogen, alkyl, alkoxy, and â€”NR32R33, R32 and R33 are individually hydrogen or alkyl or R32 and R33 together with the nitrogen atom form an unsubstituted or substituted heterocycle of 4 to 7 ring members and 1 to 3 herteroatoms selected from the group consisting of O, N and S, T is â€”(CH2)m with m=1 or 2; D is selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbocyclic or heterocyclic aryl with 5 or 6 ring members containing 1 to 4 heteroatoms selected from the group consisting of O, S and N, the carbocyclic or heterocyclic aryl unsubstituted or substituted by at least one member selected from the group consisting of alkyl, alkenyl and alkoxy of up to 6 carbon atoms, or D is â€”NR42R43, R42 and R43 are individually selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl to 6 carbon atoms, cyano, nitro and amino, or R42 and R43 together with the nitrogen form a non-aromatic heterocycle of five to six ring members, the elements of the chain being selected from the group consisting of â€”CH2â€”, â€”NHâ€”, â€”Oâ€” and â€”Sâ€”; or D is â€”SR44, R44 is alkyl of 1 to 6 carbon atoms unsubstituted or substitute with a member selected from the group consisting of â€”OH, halogen, amino, cyano and aralkyl; X is selected from the group consisting of â€”(CH2)n, â€”(CH2)nâ€”COâ€”, â€”Oâ€”(CH2)pâ€”â€”Sâ€”(CH2)p, â€”CH&boxH;CHâ€”(CH2)pâ€” and â€”CH&boxH;CHâ€”(CH2)nâ€”COâ€”, n is an integer from 0 to 6 and p is an integer from 1 to 6; W is â€”Oâ€” or â€”NR45, R45 is hydrogen or alkyl; Y is selected from the group consisting of â€”(CH2)tâ€”, â€”(CH2)qâ€”Oâ€”, â€”(CH2)qâ€”Sâ€” and â€”(CH2)qâ€”NR46â€”, R46 is hydrogen or alkyl, t is an integer from 2 to 6; and q is an integer from 2 to 6; V is selected from the group consisting of â€”(CH2)r, â€”(CH2)râ€”Oâ€”(CH2)s, â€”(CH2)râ€”Sâ€”(CH2)sâ€”, â€”(CH2)râ€”Sâ€”(O)â€”(CH2)sâ€” and â€”(CH2)râ€”S(O)2â€”(CH2)sâ€”r is an integer from 1 to 6; s is an integer from 2 to 6; and a pharmaceutically acceptable salt thereof.