Patent ID: 7671196
Filing Date: 2010-03-02
Classification: A61P,C07D

Abstract:
1. A method for preparing a compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: n is 1; R each R is independently hydrogen or a C R comprising the steps of: (a) providing a compound of formula E  wherein: (b) treating said compound of formula E with a chiral agent to form a compound of formula D-1: (c) obtaining a compound of formula D by suitable physical means:  wherein: (d) treating said compound of formula D with a suitable base to provide a compound of formula C:  wherein: (e) alkylating said compound of formula C to form a compound of formula B:  wherein: (f) deprotecting said compound of formula B to form a compound of formula A  wherein: (g) reacting said compound of formula A with formaldehyde, or an equivalent thereof, to form a compound of formula II.