Patent ID: 6300078
Filing Date: 2001-10-09
Classification: C12Q,G01N,G16B

Abstract:
A computer system for determining a number of primary targets of a drug composition in a cell type comprising:(a) a processor;(b) a memory coupled to the processor; and(c) one or more programs encoded by the memory, the one or more programs causing the processor to determine the number of expression sets wherein(i) the expression sets each comprise a plurality of cellular constituents having similar inflection concentrations of the drug composition;(ii) the inflection concentration of the drug composition for a cellular constituent is the level of exposure to the drug composition at which the cellular constituent is increased or decreased by the drug composition in a drug response; and(iii) the drug response comprises measured amounts of the pluralities of cellular constituents in a cell of the cell type at a plurality of levels of exposure of said cell type to the drug composition,wherein each expression set indicates the presence of a different primary target of the drug composition in the cell type.