Patent ID: 6093409
Filing Date: 2000-07-25
Classification: A61K,A61Q

Abstract:
A method for treating the clinical signs of skin aging in a subject in need of such treatment, comprising topically applying thereto an anti-free radical effective amount of the dermocosmetic composition wherein said dermocosmetic composition comprises an anti-free-radical effective amount of at least one melatonin derivative having structural formula (I): ##STR4## in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, with the proviso that the hydroxyl radical is in the 6- or 7-position on the indole ring system, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor, and wherein the amount of said at least one melatonin derivative ranges from 10.sup.-14 % to less than