Patent ID: 7276520
Filing Date: 2007-10-02
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein X and Y are independently selected from the group consisting of wherein alkenyl, phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 , and wherein alkyl, cycloalkyl, heterocycloalkyl, and (CH 2 ) are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 , and wherein alkyl, cycloalkyl and (CH 2 ) are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 , and wherein alkyl is unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; each R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy, and wherein alkyl, cycloalkyl, heterocycloalkyl, and (CH 2 ) are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, oxo, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy, or wherein two R 3 substituents on the same carbon atom are taken together with the carbon atom to form a cyclopropyl group; each R wherein alkyl, phenyl, heteroaryl, heterocycloalkyl, cycloalkyl, bicycloalkyl, and (CH 2 ) are unsubstituted or substituted with one to three groups independently selected from halogen, C 1-4 alkyl, hydroxy, and C 1-4 alkoxy, or two R 4 groups together with the atom to which they are attached form a 4- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and —NC 1-4 alkyl; each R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 , and wherein alkyl, (CH 2 ) and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo, or wherein two R 5 groups together with the atom to which they are attached form a 5- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and —NC 1-4 alkyl; R r is 1 or 2; s is 0, 1, or 2; t is 1, 2, or 3; n is 0, 1 or 2; and p is 0, 1, or 2.