Patent ID: 7417130
Filing Date: 2008-08-26
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A collection of nucleic acid molecules encoding a collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein each of said repeat modules is derived from one or more repeat units, wherein said repeat units are ankyrin repeats and wherein said repeat units comprise framework residues, which contribute to the folding topology of said repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein said repeat proteins differ from other repeat proteins in said collection in at least one amino acid position of the repeat modules, and wherein said derivation of each of said repeat modules is carried out by an analysis comprising the steps of wherein said structural and sequence analysis includes the identification of said framework residues and said target interaction residues of said repeat units; and