Patent ID: 6828332
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:W represents; X represents O or S; Y represents â€”C(&boxH;O)â€”, â€”CH(OH)â€”, â€”CH2â€”, S, SO, or SO2;  represents a single or a double bond; n is 1, 2, 3 or 4; R1a, R1b, R1c, R1d, and R2 are each independently H, F, Cl, Br, I, OH, C1-C6alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, phenyl, NO2, â€”NR7R8, CN or phenyl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; R3 represents H, OH, hydroxy(C1-C6)alkyl, C1-C6 alkyl, or C1-C6 alkoxy; R4 represents aryl, heterocycle, C3-C8 cycloalkyl, aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; or heterocycle substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; R5 represents aryl, heterocycle, C3-C8 cycloalkyl, aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl C1-C6 alkoxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; heterocycle substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; or C3-C8 cycloalkyl substituted with C1-C4 alkyl; R6a and R6b are each independently H or C1-C3 alkyl; R7 and R8 are each independently H, C1-C6 alkyl, aryl or aryl substituted with from 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 alkoxy, halo(C1-C6)alkyl, phenyl, NO2, NH2, or CN; or a pharmaceutically acceptable salt thereof.