Patent ID: 8945569
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody that specifically binds to an extracellular domain of human Jagged, wherein the antibody comprises: (a) a heavy chain CDR1 comprising SYWIH (SEQ ID NO:9), a heavy chain CDR2 comprising RIYPGIGSTYYNEKFKD (SEQ ID NO:10), and a heavy chain CDR3 comprising NGGFFDY (SEQ ID NO:11); and a light chain CDR1 comprising RASESVDSYGNSFMH (SEQ ID NO:12), a light chain CDR2 comprising RASNLES (SEQ ID NO:13), and a light chain CDR3 comprising QQSNEDPWT (SEQ ID NO:14); (b) a heavy chain CDR1 comprising SYAMH (SEQ ID NO:23), a heavy chain CDR2 comprising VISYDGSNKYYADSVKG (SEQ ID NO:24), AIYPDSSNKYYADSVKG (SEQ ID NO:47), AISPEASNKYYADSVKG (SEQ ID NO:48), or AIYPASSNKYYADSVKG (SEQ ID NO:49), and a heavy chain CDR3 comprising DKYDIPDAFDI (SEQ ID NO:25); and a light chain CDR1 comprising RASQGISNDLA (SEQ ID NO:26), a light chain CDR2 comprising ATSTLQS (SEQ ID NO:27), and a light chain CDR3 comprising QQSYNAPI (SEQ ID NO:28); or (c) a heavy chain CDR1 comprising SSNWWS (SEQ ID NO:37), a heavy chain CDR2 comprising EIFHGENTNYNPSLKS (SEQ ID NO:38), and a heavy chain CDR3 comprising NPGIGAAKFDS (SEQ ID NO:39); and a light chain CDR1 comprising KSSQSLLHSDGKTYLY (SEQ ID NO:40), a light chain CDR2 comprising EVSNRFS (SEQ ID NO:41), and a light chain CDR3 comprising MQHIDFP (SEQ ID NO:42).