Patent ID: 6492363
Filing Date: 2002-12-10
Classification: C07C,C07D

Abstract:
The compounds of Formula I wherein:R1 is hydroxy, C1-C8 alkyl, C1-C8 alkoxy, halo, trifluoromethyl, or CN; R2 is hydrogen; R3 and R4 independently are hydrogen, hydroxy, halo, trifluoromethyl, C1-C8 alkyl, C1-C8 alkoxy, nitro, CN, or â€”(O or NH)mâ€”(CH2)nâ€”R9, where R9 is hydrogen, hydroxy, COOH, or NR10R11; R5 is C1-C8 alkoxy or nitro; n is 0-4; m is 0 or 1; R10 and R11 independently are hydrogen or C1-C8 alkyl, or taken together with the nitrogen to which they are attached form a 3-10 member cyclic ring optionally containing 1, 2, or 3 additional heteroatoms selected from O, S, NH, or Nâ€”C1-C8 alkyl; Z is COOR7, tetrazolyl, CONR6R7, CONHNR10R11, or CH2OR7; R6 and R7 independently are hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, heteroaryl, C3-C10 cycloalkyl, or C3-C10 cycloalkyl, optionally containing one, two, or three heteroatoms selected from O, S, NH, or N alkyl; or R6 and R7 together with the nitrogen to which they are attached complete a 3-10 member cyclic ring optionally containing 1, 2, or 3 additional heteroatoms selected from O, S, NH, or N alkyl; and wherein any of the foregoing alkyl, alkenyl, and alkynyl groups can be unsubstituted or substituted by halo, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cycloalkyl, aryl, aryloxy, heteroaryl, or heteroaryloxy, and the pharmaceutically acceptable salts thereof.