Patent ID: 7702465
Filing Date: 2010-04-20
Classification: G16B

Abstract:
1. A method for predicting the binding affinity of a peptide for a major histocompatibility (MHC) class I or class II molecule, the method being executed on a computer under the control of a program stored on the computer, comprising the following steps: a) receiving a representation of a complete or partial three-dimensional structure of a MHC class I or class II molecule, b) obtaining an ensemble of conformational representations of peptide backbone structures of said peptide, said conformational representations located within the binding site of said MHC molecule, c) modeling the side-chains of said peptide for each peptide backbone structure of said ensemble in relation to said MHC molecule, thereby obtaining an ensemble of modeled MHC/peptide complexes, d) evaluating the binding properties of said peptide for said MHC molecule, by using scoring function which combines at least: e) outputting said evaluation to a user in a user-readable format.