Patent ID: 6369092
Filing Date: 2002-04-09
Classification: A61K

Abstract:
A method for inhibiting the growth of neoplastic cells comprising exposing the cells to a growth inhibiting effective amount of a compound of Formula I: whereinR1 is substituted or unsubstituted aryl, and wherein said aryl group is selected from the group consisting of phenyl, benzyl, pyridyl, dibenzofuranyl, naphthyl, quinolinyl and isoquinolinyl and wherein said substituents are one to three selected from the group consisting of halogen, lower alkyl, lower alkoxy, aryloxy, lower haloalkyl, CN, amino, nitro, phenyl; R2 is selected from a group consisting of hydrogen, halo-substituted or unsustituted lower alkyl, and lower alkoxy; R3 and R4 are independently selected from a group consisting of hydrogen, lower alkyl, â€”C(O)â€”R5, â€”CH2â€”R5, or â€”SO2â€”R5; R5 is selected from a group consisting of halo-substituted or unsubstituted lower alkyl, lower alkoxy, NHR6, lower alkenyl, and substituted or unsubstituted aryl, wherein said aryl group is selected from the group consisting of phenyl, benzyl, pyridyl, or pyridylmethyl, quinolinyl, thiazolyl, tetrazolyl, thiadiazolyl, and triazolyl, and wherein said substituents are one to three independently selected from a group consisting of hydrogen, lower alkyl and lower alkoxy; R6 is hydrogen or lower alkyl; R7 is selected from a group consisting of halogen, lower alkoxy, lower alkyl, lower alkoxycarbonyl, carboxyl, and carbamoyl; and x and y are 0, 1, or 2.