Patent ID: 7927821
Filing Date: 2011-04-19
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of screening for a compound or its salt that alters the binding property or signal transduction between (1) a G protein-coupled receptor protein comprising the amino acid sequence represented by SEQ ID NO: 1 or an amino acid sequence having at least 95% homology to the amino acid sequence of SEQ ID NO: 1, or a salt thereof and (2) a ligand to the receptor protein or a salt thereof, the method comprising comparing the binding amount of the ligand or a salt thereof to said receptor protein or a salt thereof or the cell stimulating activities between the following two cases: (i) the case wherein the receptor protein or salt thereof is brought in contact with the ligand or a salt thereof; and (ii) the case wherein the receptor protein or salt thereof is brought in contact with the ligand or a salt thereof and a test compound; wherein the ligand is a compound represented by formula: wherein each of Ar R each of R wherein ring A is an optionally substituted benzene ring; each of R R