Patent ID: 6482925
Filing Date: 2002-11-19
Classification: A61K,A61P,C07K

Abstract:
A purified polypeptide which is a mutated form of the soluble LAG-3 protein of residues 1-412 of SEQ ID NO:11 or of a fragment thereof comprising the extracellular domains D1 and D2, wherein said protein or fragment thereof comprises an amino acid substitution at one of the positions in SEQ ID NO:1l selected from the group consisting of:position 30 where aspartic acid is replaced by alanine (D30A), position 56 where histidine is replaced by alanine (H56A), position 77 where tyrosine is replaced by phenylalanine (Y77F), position 88 where arginine is replaced by alanine (R88A), position 103 where arginine is replaced by alanine (R103A), position 109 where aspartic acid is replace by glutamic acid (D1 09E), position 115 where arginine is replaced by alanine (R115A); or wherein said protein or fragment thereof comprises a deletion of the region between position 54 (P) and position 66 (A).