Patent ID: 8940522
Filing Date: 2015-01-27
Classification: A61B,C12Q,G01N

Abstract:
1. A method of delivering a therapy using an implantable medical device, comprising: presenting a tagged substrate into a bodily fluid, wherein the bodily fluid is blood, wherein the bodily fluid contains an enzyme and a protein substrate, and wherein presenting the tagged substrate to the bodily fluid comprises controlling a substrate pump to present the tagged substrate to the blood via a catheter with a distal end located in a blood vessel of a patient, and further wherein the tagged substrate is tagged with at least two fluorescent dyes; emitting energy at a first wavelength into the bodily fluid that contains the enzyme and the protein substrate, and into which the substrate tagged with the at least two fluorescent dyes has been presented; detecting energy emitted by a first one of the dyes at a second wavelength based on fluorescent resonant energy transfer from a second one of the dyes in response to the emitted energy at the first wavelength; and providing a therapy device comprising a therapy pump configured to deliver a therapy based on the detected energy.