Patent ID: 8637231
Filing Date: 2014-01-28
Classification: A01N,A61K,A61P

Abstract:
1. A method of increasing the volume of available blood substitute for treatment in a subject in need thereof, comprising: obtaining a volume of donor blood; determining the hematocrit (Hct) of said donor blood; isolating red blood cells (RBCs) from said donor blood; and diluting said isolated RBCs with a plasma expander to a final Hct of not less than 10% but not greater than 70%, wherein said plasma expander consists essentially of: (a) from 0.1 to 10 percent by weight of basic alpha keratose; said basic alpha keratose having an average molecular weight of from 10 to 100 kilodaltons; (b) from 0 to 5 percent by weight of gamma keratose; and (c) from 90 to 99.9 percent by weight of an electrolyte solution; with said basic alpha keratose and said gamma keratose solubilized in said electrolyte solution to form a homogeneous liquid composition having: