Patent ID: 8822495
Filing Date: 2014-09-02
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) wherein: R1, R1′, R1″ and R1′″ are independently of one another H, F, Cl, Br, I, OH, CF R3, R4, R5, R6, R7 and R9 are independently of one another H or (C or R3 and R4, or R5 and R6 independently of one another taken together with the nitrogen atom to which they are bonded form a 5-6 membered ring which optionally contains one additional heteroatom selected from the group consisting of NH, N—(C R8, R10 and R11 are independently of one another H, (C R12 and R13 are independently of one another H, or (C R14 is H, (C x is 0, 1, 2, 3, 4, 5, or 6; R2 is H; Y is C(R27)(R27′)C(R28)(R28′) or C(R29)=C(R29′); R27, R27′, R28, R28′, R29 and R29′ are H; X is S, O, or C(R30)=C(R30′); R30 and R30′ are H; A is a bond or a linker having 1 to 8 members, where the members are selected from the group consisting of O, S, SO R31, R34 and R34′ are independently of one another H or (C R32 and R33 are independently of one another H, (C B is N(R35)(R36), hydroxy-(C R35, R36, R37, R38, R39, R40, R41, R42 and R43 are independently of one another H, or (C or R38 and R39, or R42 and R43 independently of one another taken together with the nitrogen atom to which they are bonded form a 5-6 membered ring which optionally contains one additional heteroatom selected from the group consisting of NH, N—(C Q is mono-, bi-, tri- or spirocyclic saturated or partly unsaturated ring structure having one nitrogen atom and 0-3 additional heteroatoms selected from the group consisting of N, O and S, where the ring of the structure may be spiro-linked, fused or bridged, and where the ring system is optionally substituted one or more times by substituents selected from the group consisting of F, OH, CF or Q is selected from the group consisting of: each of which is optionally substituted one or more times by F, OH, oxo, (C R44 is H or (C R45 and R46 are independently of one another H, (C o and p are independently of one another 0, 1, 2, 3, 4, 5 or 6; R47 and R48 are independently of one another OH, F, O—(C R49, R50, R51, R52, R55 and R56 are independently of one another H or (C or R49 and R50 taken together with the nitrogen atom to which they are bonded form a 5-6 membered ring which optionally contains one additional heteroatom selected from the group consisting of NH, N—(C R53 and R54 are independently of one another H, (C R53 and R54 taken together with the nitrogen atom to which they are bonded form a 4 to 10-membered mono-, bi- or spirocyclic ring which optionally contains 1 to 3 additional heteroatoms selected from the group consisting of N, O and S, and is optionally substituted one or more times by F, Cl, Br, CF R58 and R59 are independently of one another H, (C R57, R61, R62, R64, R65, R66, R67, R68, R69, R70 and R71 are independently of one another H or (C or R69 and R70 taken together with the nitrogen atom to which they are bonded form a 5-6 membered ring which optionally contains one additional heteroatom selected from the group consisting of NH, N—(C q and r are independently of one another 0, 1, 2, 3, 4, 5 or 6; R60 and R63 are independently of one another OH, F, O—(C R72, R73, R74, R76, R77 and R78 are independently of one another H or (C or R72 and R73, or R76 and R77 independently of one another taken together with the nitrogen atom to which they are bonded form a 5-6 membered ring which optionally contains one additional heteroatom selected from the group consisting of NH, N—(C or a hydrate, solvate, or pharmaceutically acceptable salt thereof.