Patent ID: 6652836
Filing Date: 2003-11-25
Classification: A61B,A61K

Abstract:
A method for in vivo diagnosis of diseased tissue in a subject in need thereof, said method comprising:irradiating an in vivo exposed body cavity of the subject containing diseased tissue with light having at least one excitation wavelength in the range from about 401 nm to about 500 nm, directly viewing without the aid of an endoscope fluorescence emitted from the exposed body cavity in response to the light from a fluorescent targeting construct comprising an antibody or a tumor avid entity and a biologically compatible fluorescing moiety responsive to the excitation wavelength administered to the subject and which has specifically bound to and/or been taken up by the diseased tissue in the exposed body cavity, and determining the location and/or surface area of the diseased tissue in the subject from the fluorescence provided by the targeting construct.