Patent ID: 6465423
Filing Date: 2002-10-15
Classification: A61K,A61P,C07K

Abstract:
A method for increasing the half-life of insulin-like growth factor in vivo in animals or humans, said method comprising:administering to said animal or human a therapeutically effective amount of a composition comprising a purified acid-labile subunit (ALS) of insulin-like growth factor binding protein complex, wherein in vivo, the ALS is in complexed form with insulin-like growth factor-I and acid-stable insulin-like growth factor binding protein, whereby the half life of insulin-like growth factor in vivo is increased, and wherein said ALS comprises a partial N-terminal amino acid sequence comprising: Gly AspProGlyThrProGlyGluAlaGluGlyProAlaCysProAlaAlaCysAla wherein the first amino acid may be Gly or Ala (SEQ ID NOs:1 and 2, respectively, with SEQ ID NO:1 starting with Gly and SEQ ID NO:2 starting with Ala).