Patent ID: 7186854
Filing Date: 2007-03-06
Classification: C07C

Abstract:
1. A process for making bicalutamide, which comprises reacting a compound of formula (2) wherein Z represents a cation, with a suitable reaction partner to form a bicalutamide of formula (1): or a non-bicalutamide product and, if said reacting step produces said non-bicalutamide product, then converting said non-bicalutamide product to a bicalutamide of formula (1); wherein said suitable reaction partner is a compound of the formula (3), formula (3.1) or Formula (3.2): wherein A represents OR, in which R is a hydrogen, a C 1 –C 6 alkyl, a C 3 –C 6 cycloalkyl, a phenyl, or a benzyl group; or an aniline derivative of the formula: Y represents a leaving group and X represents hydrogen or X and Y join together to form a 3- to 6-membered heterocyclic ring or X and A join together to form a 5- to 10-membered fused or unfused heterocyclic ring with the proviso that if a ring nitrogen is present, it may be substituted by a 3-trifluoromethyl-4-cyano-phenyl group: wherein Y is as defined for formula (3); wherein Y is as defined for formula (3).