Patent ID: 6162823
Filing Date: 2000-12-19
Classification: C07C,C07D

Abstract:
A compound having the structure: ##STR46## and pharmaceutically acceptable salts and stereoisomers thereof wherein Ar.sup.1 is an aryl moiety selected from the group. consisting of: ##STR47## Ar.sup.2 is an aryl moiety selected from the group consisting of: (i) phenyl, mono-, di-, or tri-substituted phenyl with the substituents selected from the group. consisting of Cl, Br, F, CF.sub.3, lower alkyl, lower alkoxy, NH.sub.2, NO.sub.2, and OH;(ii) 2-, 4- or 5- thiazolyl,(iii) 2-, 3- or 4-pyridinyl,(iv) 2- or 3-thienyl, and(v) 2- or 3-furyl;Q is selected from the group consisting of:(i) --O--;(ii) --CH.sub.2 --,(iii) --OCH.sub.2 --,(iv) --CH.sub.2 O--,(v) --NH--;(vi) --NHCH.sub.2 --,(vii) --CH.sub.2 NH--,(viii) --CF.sub.2 --,(ix) --CH.dbd.CH--,(x) --CH.sub.2 CH.sub.2 --, and(xi) carbon-carbon single bond;Y is selected from the group consisting of(i) --O--,(ii) --S--,(iii) --NH--,(iv) --S(O)--, and(v) --S(O.sub.2)--;R.sup.1 is hydrogen, lower alkyl, lower alkoxy or cyclic alkyl;R.sup.2 is lower alkyl or phenyl optionally substituted with lower alkyl or halogen or NR.sup.1 (CH.sub.2)--CONHSO.sub.2 R.sup.2 taken together forms pyrrolidino, piperidino, or piperazino substituted with (CH.sub.2).sub.p --CONHSO.sub.2 R.sup.2 and wherein the pyrrolidino, piperidino, or piperazino group is optionally substituted with one or two lower alkyl groups;R.sub.7, R.sub.8, and R.sub.9 are independently H, halogen, lower alkyl, lower alkoxy, NH.sub.2, NO.sub.2 or OH;m is an integer from 2 to 4;n is an integer from 2 to 6; andp is an integer from 1 to 3.