Patent ID: 8722720
Filing Date: 2014-05-13
Classification: A61P,C07D

Abstract:
1. A compound according to the formula, a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein n is 1, 2, or 3; p is 0 or 1; each R R R R R R R is hydrogen, C provided that the compound is not 4-(2-(2-bromophenethoxy)phenyl)-1H-imidazole; 3-(2-chlorophenethoxy)-2-(1H-imidazol-5-yl)phenol; 5-(2-(4-chlorobenzyloxy)phenyl)-1H-imidazole; 4-(2-(2-chlorophenethoxy)phenyl)-1H-imidazole; 4-(2-(2-cyclohexylethoxy)phenyl)-1H-imidazole; 4-(2-(2-cyclopropylethoxy)phenyl)-1H-imidazole; 5-(2-(2-cyclopentylethoxy)phenyl)-1H-imidazole; 4-(2-phenethoxyphenyl)-1H-imidazole; 5-(2-(3-chlorobenzyloxy)phenyl)-1H-imidazole; 4-(2-(3-chlorophenethoxy)phenyl)-1H-imidazole; N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)acetamide; N-(3-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)acetamide; 5-(2-(3-phenylpropoxy)phenyl)-1H-imidazole; 4-(2-(benzyloxy)phenyl)-1H-imidazole; 4-(3-bromo-2-(4-chlorobenzyloxy)phenyl)-1H-imidazole; 4-(2-(4-chlorophenethoxy)phenyl)-1H-imidazole; 3-(4-chlorobenzyloxy)-2-(1H-imidazol-5-yl)phenol; 4-(2-(2-chlorobenzyloxy)phenyl)-1H-imidazole; 3-((2-(1H-imidazol-4-yl)phenoxy)methyl)piperidine; 1-(4-((2-(1H-imidazol-4-yl)phenoxy)methyl)piperidin-1-yl)ethanone; 1-(3-((2-(1H-imidazol-4-yl)phenoxy)methyl)piperidin-1-yl)ethanone; 4-(2-(2-bromophenethoxy)phenyl)-1H-imidazole; tert-butyl 4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)piperidine-1-carboxylate; 1-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)piperidin-1-yl)ethanone; 4-((2-(1H-imidazol-4-yl)phenoxy)methyl)piperidine; N-(2-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)acetamide; 4-((2-(1H-imidazol-5-yl)phenoxy)methyl)-7-methoxy-2H-chromen-2-one; 3-(2-(2-(1H-imidazol-5-yl)phenoxy)ethyl)-1H-indole; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(4-(pyrrolidin-1-yl)phenyl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(benzofuran-2-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(thiazol-2-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(benzofuran-5-yl)ethanone; 2-(3-(2-(1H-imidazol-5-yl)phenoxy)propyl)isoindoline-1,3-dione; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(4-(diethylamino)phenyl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(thiophen-3-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(thiophen-2-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(benzofuran-3-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(pyridin-2-yl)ethanone; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(pyridin-4-yl)ethanone; 1-(2-(2-(1H-imidazol-5-yl)phenoxy)ethyl)-1H-pyrazole; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(benzo[b]thiophen-5-yl)ethanone; 2-(2-(2-(1H-imidazol-5-yl)phenoxy)ethyl)isoindoline-1,3-dione; 2-(2-(1H-imidazol-5-yl)phenoxy)-1-(3-phenylisoxazol-5-yl)ethanone; 5-(2-(2-(2,3-dihydrobenzofuran-5-yl)ethoxy)phenyl)-1H-imidazole; 5-(2-(1-phenylpropan-2-yloxy)phenyl)-1H-imidazole; 3-(2-(2-(1H-imidazol-5-yl)phenoxy)acetyl)-2H-chromen-2-one; 2-(2-(1H-imidazol-5-yl)phenoxy)-2,3-dihydro-1H-inden-1-one; 5-(2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methoxy)phenyl)-1H-imidazole; 5-(2-(2-(1H-pyrrol-1-yl)ethoxy)phenyl)-1H-imidazole; 2-((2-(1H-imidazol-5-yl)phenoxy)methyl)-1H-benzo[d]imidazole; 6-(2-(2-(1H-imidazol-5-yl)phenoxy)acetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-(2-(2-(1H-imidazol-5-yl)phenoxy)acetyl)benzo[d]oxazol-2(3H)-one; 2-((2-(1H-imidazol-5-yl)phenoxy)methyl)pyridine; 5-((2-(1H-imidazol-5-yl)phenoxy)methyl)-2-chloropyridine; 4-((2-(1H-imidazol-5-yl)phenoxy)methyl)pyridine; 2-((2-(1H-imidazol-5-yl)phenoxy)methyl)quinazolin-4(3H)-one; 2-((2-(1H-imidazol-5-yl)phenoxy)methyl)quinoline; 3-((2-(1H-imidazol-5-yl)phenoxy)methyl)quinoxalin-2(1H)-one; 3-((2-(1H-imidazol-5-yl)phenoxy)methyl)benzo[d]thiazol-2(3H)-one; 5-(2-(naphthalen-2-ylmethoxy)phenyl)-1H-imidazole; and 5-(2-(2-(naphthalen-1-yl)ethoxy)phenyl)-1H-imidazole.