Patent ID: 8541403
Filing Date: 2013-09-24
Classification: A61K,A61N,A61P,C07D

Abstract:
1. A method of polymerase (PARP) in a treating a disease associated with a PTEN deficiency ameliorated by the inhibition of PARP, wherein the disease associated with a PTEN deficiency is endometrial carcinoma, comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I): wherein: Y and Z are each independently selected from the group consisting of: R A and B are each independently selected from the group consisting of hydrogen, Br, Cl, F, I, OH, C R R each R a single isomer, stereoisomer, or enantiomer, or mixture thereof, optionally as a salt, solvate, chemically protected form or prodrug thereof.