Patent ID: 8697368
Filing Date: 2014-04-15
Classification: C07K,G01N

Abstract:
1. A method for diagnosing lung cancer, comprising: (a) obtaining a blood sample from a subject and isolating a serum fraction from the blood sample; (b) contacting the serum fraction with an anti-HpαR (haptoglobin alpha 2 chain with C-terminal arginine) antibody; (c) measuring the concentration of HpαR in the serum fraction; and (d) diagnosing the subject with lung cancer based on the concentration of the HpαR; wherein the anti-HpαR antibody specifically binds to a C-terminal amino acid sequence CKLPECEAVCGKPKNPANPVQR (SEQ ID NO: 1) of HpαR and not to a C-terminal sequence of CKLPECEAVCGKPKNPANPVQ (SEQ ID NO: 2) of HpαQ (haptoglobin alpha 2 chain without C-terminal arginine).