Patent ID: 6492344
Filing Date: 2002-12-10
Classification: C07K,C12N

Abstract:
A method for promoting cutaneous wound healing, said method comprising:(a) providing, by directly introducing to a cutaneous wound site, a recombinant expression vector comprising the syndecan enhancer element, FiRE, operably linked to a FiRE-activated promoter wherein said syndecan enhancer element is less than or about 280 nucleotides of SEQ ID No. 5 in length and comprises binding sites for nuclear proteins FIN-1, AP-1 and USF, and wherein said FiRE activated promoter is operably linked to a structural gene encoding a growth factor that promotes said cutaneous wound healing; and (b) inducing expression of said structural gene encoding said growth factor by activating said syndecan enhancer element, wherein expression of said growth factor promotes said cutaneous wound healing.