Patent ID: 6028209
Filing Date: 2000-02-22
Classification: C07F

Abstract:
A process for the preparation of C14-C18-alkylphosphocholines, comprising(i) reacting an n-alkanol having a chain length of C14-C18 with phosphorus oxychloride in the presence of a halogenated hydrocarbon in a single vessel;(ii) reacting product obtained, without isolation and purification, in a halogenated hydrocarbon with a choline salt in the presence of a basic substance to form corresponding phosphoric acid diester chloride;(iii) hydrolyzing the phosphoric acid diester chloride to liberate alkylphosphocholine crude product in an organic phase;(iv) washing the organic phase at least one time with a solvent comprising a mixture selected from the group consisting of water and an acid substance, water and an alcohol, and water and a basic substance;(v) separating the organic phase and evaporating the solvent, optionally in the presence of an aliphatic alcohol to obtain alkylphosphocholine crude product;(vi) suspending the alkylphosphocholine crude product in a saturated aliphatic ketone with 3 to 6 carbon atoms; and(vii) recovering the alkylphosphocholine.