Patent ID: 6897034
Filing Date: 2005-05-24
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of designing a prodrug, the method comprising: (1) providing an oligopeptide of the formula (AA) (2) linking the oligopeptide at a first attachment site of the oligopeptide to a stabilizing group that hinders cleavage of the oligopeptide by enzymes present in whole blood, and (3) directly or indirectly linking the oligopeptide to a therapeutic agent at a second attachment site of the oligopeptide, wherein steps (2) and (3) may be performed in any order or concurrently and further wherein a conjugate is formed by performance of steps (1) through (3), (4) testing if the conjugate is cleavable by CD10, and (5) selecting the conjugate as a prodrug if the conjugate is cleavable by CD10.