Patent ID: 6506756
Filing Date: 2003-01-14
Classification: A61P,C07D

Abstract:
A compound, or enantiomers, stereoisomers and tautomers thereof, or pharmaceutically acceptable salts or solvates of said compound, said compound having the structure shown in Formula I: wherein:X is N or N-oxide; y is CH; f=1; G is a moiety selected from the group consisting of the moieties II, III and IV with the top end of said II, III and IV being linked to the tricyclic moiety and the bottom end of II, III and IV being linked to M: â€ƒwhere s=t=1 or 2; and p=q=0, 1 or 2; M is a moiety selected from the group consisting of C1-C8 alkyl; â€”C(O)â€”(CH2)yâ€”; â€”(CH2)xâ€”Aâ€”(CH2)yâ€”; â€”C(O)â€”Oâ€”(CH2)dâ€”; and â€”C(O)â€”NR3â€”(CH2)dâ€”; where A&boxH;O, S(O)râ€”, and â€”NR4â€”; n=0, 1, 2 or 3; x is a whole number in the range 2-5; y is a whole number in the range 0-5; d is a number in the range 0-5; r=0, 1 or 2; R1 and R2 may each number 1-3 and are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, OCF3, OCHF2, â€”OH, and â€”N(R4)2; R3 is selected from the group consisting of hydrogen, lower alkyl, and polyhaloloweralkyl; R4 is selected from hydrogen, lower alkyl, polyhalolower alkyl; and R5 is H, C1-C6 alkyl or OH.