Patent ID: 6165711
Filing Date: 2000-12-26
Classification: A61K,A61L,C12N

Abstract:
A method for disintegrating nucleic acids in a biologically active proteinaceous material that has biological integrity, comprising admixing a phenothiazine photodynamic substance to the biologically active material to form a mixture, andexposing the mixture to at least one cycle of irradiation with laser beam light having an intensity of .ltoreq.0.1 J/cm.sup.2 per cycle in order to (i) reduce nucleic acid template activity in the biologically active material by at least a factor of 7 log steps and/or (ii) to reduce the nucleic acid content to less than 100 pg/ml, thereby disintegrating and/or inactivating substantially all biologically active nucleic acid contained in the biologically active material while substantially retaining the biological integrity and activity of the biologically active material.