Patent ID: 6207156
Filing Date: 2001-03-27
Classification: A61K,A61P,C07K

Abstract:
A composition, comprising an isolated CTLA-4 specific antibody or antibody fragment that selectively binds to human CTLA4 and co-stimulates T-cell proliferation,wherein the isolated CTLA-4 specific antibody or antibody fragment comprises a CDR selected from the group consisting of a CDR from monoclonal antibody.sub.A3.4H2 produced by hybridoma A3.4H2 deposited under ATCC Accession No. HB-12319 and a CDR from monoclonal antibody.sub.A3.6B10 produced by hybridoma A3.6B10 deposited under ATCC Accession No. HB-12318.