Patent ID: 7144876
Filing Date: 2006-12-05
Classification: A61K,A61P

Abstract:
1. A pharmaceutical preparation comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of: 3-(3-Amino-4-chloro-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]-oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(3-dimethylamino-4-chloro-phenyl)-[1,2,4]-oxadiazole; 3-(3-Amino-4-chloro-phenyl)-5-(3-bromofuran-2-yl)-[1,2,4]-oxadiazole; 5-(3-Bromofuran-2-yl)-3-(3-dimethylamino-4-chloro-phenyl)-[1,2,4]-oxadiazole; N-{2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-2-(4-methyl-piperazin-1-yl)-acetamide; N-{2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-succinamic acid ethyl ester; 5-(3-Chlorothiophen-2-yl)-3-(4-chloro-3-cyano-phenyl)-[1,2,4]-oxadiazole; 3-(4-Chloro-benzyloxy)-5-(3-chlorothiophen-2-yl)-[1,2,4]-oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(4-chloro-3-fluoro-phenyl)-[1,2,4]-oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(4-chloro-3-nitro-phenyl)-[1,2,4]-oxadiazole; 3-(5-Chloro-pyridin-2-yl)-5-(3-methoxy-thiophen-2-yl)-[1,2,4]-oxadiazole; 3-(5-Chloro-pyridin-2-yl)-5-(3-methyl-3H-imidazol-4-yl)-[1,2,4]-oxadiazole; 3-[2-(4-Chloro-phenyl)-vinyl]-5-(3-chlorothiophen-2-yl)-[1,2,4]-oxadiazole; 5-(3-Chloro-1H-pyrrol-2-yl)-3-(5-chloro-pyridin-2-yl)-[1,2,4]-oxadiazole; 3-(4-Chloro-phenyl)-5-(3-chloro-1H-pyrrol-2-yl)-[1,2,4]-oxadiazole; 5-(3-Chloro-1-methyl-1H-pyrrol-2-yl)-3-(4-chloro-phenyl)-[1,2,4]-oxadiazole; 5-[3-Chloro-1-(2-dimethylaminoethyl)-1H-pyrrol-2-yl]-3-(4-chloro-phenyl)-[1,2,4]-oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(morpholin-4-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(pyrrolidin-1-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(4-methylpiperidin-1-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(2-methylpiperidin-1-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(4-trifluoromethylpiperidin-1-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(4-methylpiperazin-1-yl)-[1,2,4]oxadiazole; 4-[5-(3-Chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-piperazine-1-carboxylic acid benzyl ester; 4-[5-(3-Chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-piperazine-1-carboxylic acid tert-butyl ester; {1-[5-(3-Chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidin-4-yl}-carbamic acid tert butyl ester; {1-[5-(3-Chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidin-4-yl}-acetic acid ethyl ester; {1-[5-(3-Chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidin-3-yl}-acetic acid ethyl ester; 5-(3-Chlorothiophen-2-yl)-2-(piperidine-1-yl)-[1,3,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-2-(morpholin-4-yl)-[1,3,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-2-(4-methylpiperazin-1-yl)-[1,3,4]oxadiazole; 4-[5-(3-Bromofuran-2-yl)-[1,2,4]oxadiazol-3-yl]-piperazine-1-carboxylic acid benzyl ester; 4-[5-(3-Bromofuran-2-yl)-[1,2,4]oxadiazol-3-yl]-piperazine-1-carboxylic acid tert-butyl ester; 5-(3-Chlorothiophen-2-yl)-2-(piperazin-1-yl)-[1,3,4]oxadiazole trifluoroacetic acid salt; 5-(3-Bromofuran-2-yl)-2-(piperazin-1-yl)-[1,3,4]oxadiazole trifluoroacetic acid salt; 5-(3-Chlorothiophen-2-yl)-3-(4-aminopiperidin-1-yl)-[1,2,4]oxadiazole trifluoroacetic acid salt; 5-(3-Chlorothiophen-2-yl)-3-(thiophen-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(furan-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(furan-3-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-2-methyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(5-methylfuran-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(5-nitrofuran-2-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-2-fluoro-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 5-(3-Chlorothiophen-2-yl)-3-(3-methyl-pyridin-2-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-3-methyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 5-(3-Bromofuran-2-yl)-3-(4-chloro-2-methyl-phenyl)-[1,2,4]oxadiazole; 5-(3-Bromofuran-2-yl)-3-(5-chloro-3-methyl-pyridin-2-yl)-[1,2,4]oxadiazole; {2-Chloro-5-[5-(3-chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-phenylamino}-acetic acid ethyl ester; N′-{2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-N,N-diethyl-ethane-1,2-diamine; {2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-(2-morpholin-4-yl-ethyl)-amine; ({2-Chloro-5-[5-(3-chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methylamino)-acetic acid ethyl ester; ({2-Chloro-5-[5-(3-chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methylamino)-acetic acid; ({2-Chloro-5-[5-(3-chlorothiophene-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methylamino)-acetic acid N-hydroxysuccinimidyl ester; 5-(3-Bromofuran-2-yl)-3-(3-methyl-pyridin-2-yl)-[1,2,4]oxadiazole; 4-({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-butyric acid methyl ester; 4-({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-butyric acid; 4-({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-butyric acid N-hydroxysuccinimidyl ester; 4-({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-1-(4-methyl-piperazin-1-yl)-butan-1-one; N-Butyl-4({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-butyramide; 4-({2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methyl-amino)-butyric acid octyl ester; {2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-ethyl-amine; N-{2-Chloro-5-[5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetamide; 3-(3-Bromomethyl-4-chloro-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 3-(2-Bromomethyl-4-chloro-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-3-pyrrolidin-1-ylmethyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-3-dimethylaminomethyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; 3-(4-Chloro-2-pyrrolidin-1-ylmethyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; and 3-(4-Chloro-2-dimethylaminomethyl-phenyl)-5-(3-chlorothiophen-2-yl)-[1,2,4]oxadiazole; or a pharmaceutically acceptable salt or prodrug thereof; a) an ester of a carboxylic acid containing compound of Formula IV obtained by condensation with a C b) an ester of a hydroxy containing compound of Formula IV obtained by condensation with a C c) an imine of an amino containing compound of Formula IV obtained by condensation with a C d) a carbamate of an amino containing compound of Formula IV; or e) an acetal or ketal of an alcohol containing compound of Formula IV obtained by condensation with chloromethyl methyl ether or chloromethyl ethyl ether.