Patent ID: 6110947
Filing Date: 2000-08-29
Classification: A61P,C07D,Y02P

Abstract:
A compound of the following formula ##STR7## and a salt thereof wherein A is hydrogen, hydroxy or OY wherein Y is a hydroxy protecting group selected from benzyl, triphenylmethyl, tetrahydropyrandyl, methoxymethyl and Si, R.sup.1, r.sup.2, R.sup.3 wherein R.sup.1, R.sup.2 and R.sup.3 are each C.sub.1 -C.sub.6 alkyl or phenyl;Ar is phenyl optionally substituted with one or more substituent selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyloxy and carboxy-C.sub.1 -C.sub.4 alkyloxy;X is benzofuranyl, benzothiophenyl, and pyridyl, these groups optionally being substituted with up to three substituents selected from halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, NO.sub.2, CF.sub.3 and SO.sub.2 CH.sub.3 ; andR is hydrogen, C.sub.1 -C.sub.4 alkyl or a hydroxy protecting group selected from benzyl, triphenylmethyl, tetrahydropyranyl, methoxymethyl and Si, R', R.sup.2, R.sup.3 wherein R', R.sup.2, R.sup.3 are each C.sub.1 -C.sub.6 alkyl or phenyl.