Patent ID: 6573247
Filing Date: 2003-06-03
Classification: A61P,C07H

Abstract:
A compound having the formula: wherein:R is selected from the group consisting of C6 to C20 alkyl, C5 to C20 cycloalkyl, halogens, aryl and alkylaryl, with the proviso that R is not 4-FC6H4, C6F5, 4-MeOC6H4, 3,5-(CF3)2C6H3, 3,5-F2C6H3, 4CF3C6H4, or C6H5; Râ€² is selected from the group consisting of hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, and aryl; Râ€³ is selected from the group consisting of hydrogen, alkyl, cycloalkyl, halogens, alkyloxy, aryloxy, and aryl; Q is selected from the group consisting of O, S, and CY2, where Y may be the same or different and is selected from the group consisting of H, alkyl, and halogens; X is selected from the group consisting of O, NH, S, N-alkyl, (CH2)n where n is 1 to 10, and CY2, where Y may be the same or different and is selected from H, alkyl, and halogens, with the proviso that when R is an unsubstituted C6 to C10 alkyl group and Q is O, X is other than NH or N-alkyl; Z is selected from the group consisting of O, S, NH, and N-alkyl; Uâ€² and Uâ€³ are joined so as to form a ring moiety wherein Uâ€²â€”Uâ€³ together is respectively selected from the group consisting of â€”CTHâ€”CTâ€²Tâ€³â€” and â€”CT&boxH;CTâ€”, and â€”CTâ€²&boxH;CTâ€²â€”, so as to provide ring moieties selected from the group consisting of: â€ƒwherein:T is selected from the group consisting of OH, H, halogens, O-alkyl, O-acyl, O-aryl, CN, NH2, and N3; Tâ€² is selected from the group consisting of H and halogens and where more than one Tâ€² is present they may be the same or different; Tâ€³ is selected from the group consisting of H and halogens; and W is selected from the group consisting of H, a phosphate group, and a pharmacologically acceptable salt or pro-drug thereof.