Patent ID: 8022222
Filing Date: 2011-09-20
Classification: A61P,C07D

Abstract:
1. A compound selected from the Formula I and salts thereof, wherein: L is O, S, S(═O), S(═O) Y is CH; G is CH or CCl; Z is CR R R (i) phenyl optionally substituted with one or more groups independently selected from F, Cl, CN, C (ii) a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from N and O (provided the ring does not contain a O—O bond) wherein said heteroaryl is optionally substituted with one or two groups independently selected from NO (iii) a partially unsaturated 5 membered azacyclic ring optionally substituted with oxo; (iv) 9-10 membered heteroaryl ring having a nitrogen atom and optionally having 1 to 2 additional ring heteroatoms independently selected from N, O and S and optionally substituted with C (v) a 5-6 membered cycloalkyl ring optionally substituted with C R R or R R or R or R R R R R V is alkylene having from 1 to 12 carbons, or alkenylene or alkynylene each having from 2 to 12 carbons, wherein said alkylene, alkenylene, or alkynylene are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, saturated and partially unsaturated cycloalkyl, saturated and partially unsaturated heterocyclyl, aryl, heteroaryl, F, Cl, Br, I, CF n is 0 or 1.