Patent ID: 6407228
Filing Date: 2002-06-18
Classification: C07D

Abstract:
A method for the preparation of a &bgr;-lactam compound represented by the formula in which R1 is a monovalent hydrocarbon group selected from the group consisting of alkyl groups having 1 to 20 carbon atoms, cycloalkyl groups having 3 to 20 carbon atoms, aryl groups having 6 to 20 carbon atoms and aralkyl groups having 7 to 20 carbon atoms, and R2 is a monovalent hydrocarbon group selected from the group consisting of alkyl groups having 1 to 20 carbon atoms and cycloalkyl groups having 3 to 20 carbon atoms, which comprises the steps of:(a) mixing an isocyanate compound represented by the formula R1NCO, â€ƒin which R1 has the same meaning as defined above, and a vinyl ether compound represented by the formula CH2&boxH;CHâ€”Oâ€”R2, â€ƒin which R2 has the same meaning as defined above, to form a reaction mixture; and (b) bringing the reaction mixture under a superatmospheric pressure of at least 2000 atmospheres.