Patent ID: 8791279
Filing Date: 2014-07-29
Classification: C07D

Abstract:
1. A process for preparing a taxoid of general formula (X), comprising the steps of: (a) reacting a protected baccatin III derivative (B) with a β-lactam of the general formula (C) in the presence of one or more Lewis acids ML and a first base agent to obtain a protected taxoid of general formula (X and (b) removing the silyl ether protecting groups to obtain the taxoid of general formula (X); wherein: M is selected from the group consisting of cations of Li, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Ba, Cu, Ag, Au, Zn, Cd, Hg, Fe, Co, Ni, Ru, Rh, Pd, Os, Ir, Pt, Sc, Y, Ti, V, Nb, Co, B, Al, In, Sn, Ce, and any combination thereof; L is a counter ion to M; R′ R′ R′ R′ R R R R R R