Patent ID: 6252070
Filing Date: 2001-06-26
Classification: A61P,C07C,C07D

Abstract:
A process for the preparation of a compound of Formula 1 ##STR97##or a pharmaceutically acceptable salt thereof whereinR.sub.1 is hydrogen, alkyl, or alkoxy;R.sub.2 is hydrogen or alkoxy;R.sub.3 is alkyl or alkoxy;R.sub.2 and R.sub.3 may be joined to form a ring ##STR98##R.sub.4 is hydrogen or alkyl;R.sub.5 is hydrogen, alkyl, alkoxy, halogen at the 2 or 3, or 4, or 5 positions or R.sub.5 is a 3,4-methylenedioxo; andR.sub.6 is CF.sub.3, halogen, alkyl, benzyl, phenyl, hydroxy, or pyrrole comprising:a) treating aryl bromide with n-butyl lithium followed by zinc bromide to generate an aryl zinc bromide of formula Y ##STR99##b) reacting the product of step a) above with ##STR100##in THF in the presence of a palladium catalyst to produce Formula 1 ##STR101##