Patent ID: 6083981
Filing Date: 2000-07-04
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formula I ##STR13## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, or benzyl;R.sup.2 is --CHO, --COR.sup.a, or --CN;each R.sup.a is independently hydrogen or C.sub.1 -C.sub.6 alkyl;X is a bond, CH.sub.2, CHR.sup.5, NH, NR.sup.5, or O;R.sup.3 is aryl, substituted-aryl, heteroaryl, substituted-heteroaryl, cycloalkyl, substituted-cycloalkyl, heterocycle, or substituted heterocycle;Y is absent, NR.sup.5, CO, S, O, SO.sub.2, --O(CHR.sup.5).sub.n --, CHR.sup.5, NR.sup.5 CO, ##STR14## CONR.sup.5, OCHR.sup.5, CHR.sup.5 O, SCHR.sup.5, CHR.sup.5 S, SO.sub.2 NR.sup.5, C.sub.1 --C.sub.6 alkyl, NR.sup.5 SO.sub.2, CH.sub.2 CHR.sup.5 CHR.sup.5 CH.sub.2 COCH.sub.2, or CH.sub.2 CO;R.sup.4 is absent, aryl, substituted-aryl, C.sub.1 -C.sub.8 alkyl, heteroaryl, substituted-heteroaryl, cycloalkyl, C.sub.1 -C.sub.6 alkyl, substituted-cycloalkyl, heterocycloalkyl, or substituted heterocycloalkyl;each R.sup.5 is independently hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, --(CH.sub.2).sub.n aryl, or --(CH.sub.2).sub.n cycloalkyl;each n is independently 0 to 5, m is 1 or 2, and the pharmaceutically acceptable salts and amides thereof.