Patent ID: 6683079
Filing Date: 2004-01-27
Classification: A61K,A61P,C07D

Abstract:
A method of treatment of an HIV infection comprising administration of an effective amount of a compound having the formula (1) wherein:Q represents â€”NR1R2 or â€”R0NR1R2 wherein: R0 represents C1-5 alkanediyl; R1 and R2 are taken together and form a bivalent radical â€”R1-R2â€” wherein â€”R1-R2â€” represents â€”(CH2)2â€”Oâ€”(CH2)2â€”, â€”(CH2)2â€”NR7â€”(CH2)2, â€”(CH2)2â€”CH(NHR7)â€”(CH2)2â€” or â€”(CH2)n wherein R7 represents hydrogen or C1-4alkyl and n represents 2, 3, 4, 5 or 6; R3 represents phenyl or substituted phenyl: R4 and R5 each independently represent hydrogen, C1-6alkyl, C3-6alkenyl, C1-4 alkoxy, C1-4 alkyloxy C1-4 alkyl, amino, mono- or di (C1-4alkyl) amino, formyl, C1-4alkylcarbonyl carboxyl, C1-4alkyloxycarbonyl, or C1-4alkyl aminocarbonyl; wherein C1-6alkyl and C3-6alkenyl may be substituted with one, two or three substituents selected from hydroxy, C1-4alkyloxy, C1-4alkyl thio, aryloxy, arylthio, amino, mono- or di(C1-4alkyl)amino and aryl; or R4 and R5 taken together form a bivalent radical or formula â€”R4-R5â€” wherein â€”R4-R5â€” represents â€”CH&boxH;CHâ€”CH&boxH;CHâ€” or â€”(CH2)t, wherein t represents 3 or 4; R6 represents hydrogen, hydroxy, C1-4alkyloxy, C1-6alkyl, C3-6alkenyl, aryl, C1-4alkyl, amino, mono- or di(C1-4alkyl)amino or alkylaryl; Y represents O or S; X represents a radical of formula: â€”(CH2)p(a) or â€”(CH2)qâ€”Zâ€”(CH2)r(b) wherein p represents 1, 2, 3, 4 or 5; q represents 0, 1, 2, 3, 4 or 5; r represents 0, 1, 2 or 3; Z represents NR8, C(&boxH;O), CHOH, CHNR8R9; CF2, O, S or CH&boxH;CH; wherein R8 and R9 each independently represent hydrogen or C1-4alkyl; ora N-oxide, a stereochemically isomeric form or a pharmaceutically acceptable addition salt thereof.