Patent ID: 6638535
Filing Date: 2003-10-28
Classification: A61K

Abstract:
A pharmaceutical pellet comprising a substantially homogenous mixture of a rapidly-acting hypnotic agent or a pharmaceutically acceptable salt thereof and a pellet forming carrier of microcrystalline cellulose, wherein the amount of said hypnotic agent and said pellet forming carrier is at least 90% of the pellet weight, said pellet having a particle size within the range of 0.85 to 2.0 mm and wherein said pellet exhibits a dissolution profile under U.S. Pharmacopoeia XXIII, Dissolution method I, in a basket apparatus at temperature 37Â° C., in 0.01N HCl medium and at 100 r.p.m., such that at 5 minutes from the start of the test, less than 60% of the hypnotic agent has been released from the pellet.