Patent ID: 9173957
Filing Date: 2015-11-03
Classification: A61K,A61P,C07K

Abstract:
1. An FGFR2 fusion protein comprising an extracellular domain of FGFR2-IIIc and a fusion partner, wherein the extracellular domain of FGFR2-IIIchas a deletion, as compared to wild-type FGFR2-IIIc, of a sequence consisting of an amino acid sequence chosen from SEQ ID NOs: 255-261 from the wild-type extracellular domain C-terminus, wherein the extracellular domain optionally lacks the native leader sequence, wherein the wild-type extracellular domain C terminus is defined as ending with the amino acids YLE; and wherein the fusion partner is chosen from an Fc polypeptide, a polyethylene glycol, albumin, a domain of a constant region of a heavy or light chain or a mammalian immunoglobulin, and a hinge and the CH2 and CH3 constant domains of a human IgG.