Patent ID: 7432342
Filing Date: 2008-10-07
Classification: A01K,C07K

Abstract:
1. A polypeptide that is a mutein of SEQ ID NO: 2, wherein the mutein exhibits modified binding to a regulatory subunit of PKA compared to SEQ ID NO: 2 and wherein said mutein: is a peptide selected from the group consisting of a) a peptide having the sequence SEQ ID NO: 2, b) a peptide having the sequence SEQ ID NO: 2 further comprising a C-terminal cysteine, c) a peptide having the sequence SEQ ID NO: 2 wherein residues 1-8 are deleted, and d) a peptide having the sequence SEQ ID NO: 2 wherein residues 1-8 are deleted further comprising a C-terminal cysteine; except that said peptide has an amino acid residue substitution at the residue equivalent to residue 21 of SEQ ID NO: 2 of Trp and/or Ile for Val, or an amino acid residue substitution at the residue equivalent to residue 12 of SEQ ID NO: 2 of Phe for Leu; and zero, one, or two amino acid residue substitutions selected from the group consisting of Phe, Ile, Leu, Val, His, Met, Arg, Thr, Trp, or Tyr at the residue equivalent to residue 9 of SEQ ID NO: 2 for Gln; and Phe, Ile, Leu, Thr, Val, Trp, or Tyr at the residue equivalent to residue 25 of SEQ ID NO: 2 for Met.