Patent ID: 6391280
Filing Date: 2002-05-21
Classification: A61K,C07K,Y10S

Abstract:
A targeting molecule linked to at least one imaging agent, wherein said targeting molecule is a polypeptide that:(a) forms a closed covalent loop; and (b) contains at least three peptide domains having &bgr;-sheet character, each of the domains being separated by domains lacking &bgr;-sheet character; wherein said polypeptide is a J chain, or a portion thereof such that the ability of the portion to specifically bind to a basolateral factor attached to a basolateral domain of an epithelial surface causing uptake of the linked imaging agent into cells of the epithelial surface, is not substantially reduced; and wherein the polypeptide or imaging agent is further linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.