Patent ID: 6197812
Filing Date: 2001-03-06
Classification: A61K,A61P,C07D

Abstract:
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula (III): ##STR21##wherein:R=ophthalmically acceptable ester moiety, CO.sub.2 R.sup.1, CONR.sup.7 R.sup.8, CH.sub.2 OR.sup.9, or CH.sub.2 NR.sup.10 R.sup.11, where R.sup.1 =H or cationic salt moiety; R.sup.7 and R.sup.8 are the same or different=H or alkyl; R.sup.9 =H, acyl, or alkyl; R.sup.10 and R.sup.11 are the same or different=H, acyl, or alkyl; with the proviso that if one of R.sup.10 and R.sup.11 =acyl, then the other=H or alkyl;n=0, 2;G is: ##STR22##wherein:Z=C.tbd.C, trans CH.dbd.CH or CH.sub.2 CH.sub.2 ;Y.sup.2 =halogen or alkoxy;X.sup.2 =O, S, or CH.sub.2 ; andA=cis CH.dbd.CH, CH.sub.2 CH.sub.2, or C.tbd.C;R.sup.2, R.sup.3 are different=H and OH; andR.sup.4 =cyclohexyl or linear or branched C.sub.5 -C.sub.7 alkyl.