Patent ID: 7144901
Filing Date: 2006-12-05
Classification: A61K,A61P,C07D,C07K

Abstract:
1. An oxadiazole compound of formula (I), wherein R is R CycA wherein CycA is mono-, bi- or tri-cyclic C3–15 carboring AA a single bond AA wherein R CycD is a C3–14 mono- or bi-cyclic carboring, R (i) hydrogen, (ii) C1–8 alkyl, or (iii) C1–8 alkyl substituted with 1–5 of groups selected from the following (1)˜(7): (1) —NR (6) CycA, (7)-NR R R R (i) C1–8 alkyl, (ii) C2–8 alkenyl, (iii) CycA, (iv) —COR (v) C1–8 alkyl substituted with 1–3 of group selected from CycA, —COR wherein R (1) C1–4 alkyl, (2) C1–4 alkoxy, (3) CycA, (4) —O-CycA, (5) —NR (6) C1–4 alkyl substituted with CycA, (7) C1–4 alkoxy substituted with CycA, or (8) hydroxy, R R (1) hydrogen, (2) C1–8 alkyl, (3) CycA, (4) C1–8 alkyl substituted with —SiR (5) C1–8 alkyl substituted with CycA, R and, CycA's included in R R (1) C1–8 alkyl, (2) halogen, (3) —NR (4) —OR (5) a C5–10 mono- or bi-cyclic carboring, (6) nitro, (7) CF (8) cyano, (9) —SR (10) —COR (11) oxo, (12) —SO (13) —OCF (14) C1–8 alkyl substituted with 1–5 of group selected from the following (a)˜(k): (a) halogen, (b) —NR (g) cyano, (h) —SR wherein R R R or a non-toxic salt thereof.