Patent ID: 6352981
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound of the formula IAr1â€”Aâ€”Bâ€”Ar2â€ƒâ€ƒ(I) whereAr1 is â€ƒor a 5-membered heteroaromatic ring with 1, 2 or 3 heteroatoms which are selected, independently of one another, from O, N and S, where Ar1 may have 1, 2, 3 or 4 substituents which are selected, independently of one another, from OR1, alkyl which is unsubstituted or substituted by OH, OC1-C8-alkyl or halogen, or C2-C6-alkenyl, C2-C6-alkynyl, cycloalkyl, halogen, CN, CO2R1, NO2, NR1R2, SR1, CF3, CHF2, phenyl which is unsubstituted or substituted by C1-C6-alkyl, OC1-C6-alkyl, HCO, C1-C8-alkyl-CO, phenyl, amino, nitro, cyano or halogen, or phenoxy which is unsubstituted or substituted by C1-C6-alkyl, OC1-C6-alkyl, or halogen, or C1-C6-alkanoyl or benzoyl; R1 is H, alkyl which is unsubstituted or substituted by OH, OC1-C6-alkyl, phenyl or halogen; R2 has the meanings stated for R1 or is COR1 or CO2R1; A is a C3-C15-alkylene group when Ar1 is C6H5 CONH, or, when Ar1 is a 5- or 6-membered heteroaromatic ring, is a C4-C15-alkylene group or a C3-C15-alkylene group which comprises at least one group Z which is selected from O, S, NR1, a double and a triple bond, where R1 is as defined above, B is a 7- or 8-membered saturated ring with one or two nitrogen heteroatoms, the nitrogen heteroatoms being located in the 1,4 or 1,5 position and the ring being bonded in position 1 to the radical A and in position 4 or 5 to the radical Ar2, and it additionally being possible for the ring to have a double bond in position 3 or 4; Ar2 is phenyl, pyridyl, pyrimidinyl or triazinyl, it being possible for Ar2 to have 1, 2, 3 or 4 substituents which are selected, independently of one another, from OR1, alkyl, C2-C6-alkenyl, C2-C6-alkynyl, alkoxyalkyl, haloalkyl, halogen, CN, CO2R1, NO2, SO2R1, NR121, SO2NR12, SR1, a 5- or 6-membered carbocyclic, aromatic or, non-aromatic ring and a 5- or 6-membered heterocyclic aromatic or non-aromatic ring with 1 to 3 heteroatoms which are selected from O, S and N, the carbocyclic or heterocyclic ring being unsubstituted or substituted by C1-C6-alkyl, phenyl, halogen, OC1-C6-alkyl, OH, NO2 or CF3, and Ar2 may also be fused to a carbocyclic ring of the type defined above, and where Ar2 cannot be a pyrimidinyl radical substituted by 2 hydroxyl groups, and the salts thereof with physiologically tolerated acids.