Patent ID: 7705027
Filing Date: 2010-04-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (A) or (B) or a salt or N-oxide thereof: wherein R 1 is a group of formula (IB) wherein in any compatible combination R represents one or more optional substituents selected from (C Alk p, r and s are independently 0 or 1, Z is —O—, —S—, —(C═O)—, —(C═S)—, —SO Q is hydrogen or an optionally substituted phenyl or pyridinyl radical; R 2 is (i) a group of formula (IA): wherein in any compatible combination Ar Alk (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula-(Alk R 3 is a carboxyl, carboxamide, or carboxyl ester group, wherein the term optionally substituted means substituted with up to four substituents selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, hydroxy(C 1 -C 6 )alkyl, mercapto, mercapto(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile (—CN), oxo, phenyl, —COOH, —COOR A , —COR A , —SO 2 R A , —CONH 2 , —SO 2 NH 2 , —CONHR A , —SO 2 NHR A , —CONR A R B , —SO 2 NR A R B , —NH 2 , —NHR A , —NR A R B , —OCONH 2 , —OCONHR A , —OCONR A R B , —NHCOR A , —NHCOOR A , —NR B COOR A , —NHSO 2 OR A , —NR B SO 2 OH, —NR B SO 2 OR A , —NHCONH 2 , —NR A CONH 2 , —NHCONHR B , —NR A CONHR B , —NHCONR A R B or —NR A CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group.