Patent ID: 6124344
Filing Date: 2000-09-26
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a cyclopentane heptan(ene)oic acid, 2-heteroaryl alkenyl compound represented by formula II ##STR48## wherein the hatched segments represent .alpha. bonds, the solid triangle represents a .beta. bond, the wavy line represents either an .alpha. or .beta. bond, R.sup.1 is hydrogen or a lower alkyl radical hazing up to six carbon atoms, X is selected from the soup consisting of --OR.sup.1 and --N(R.sup.1).sub.2 ; Y is .dbd.O or represents 2 hydrogen radicals, Z is selected from the group consisting of O and S, A is C when A is bonded directly to said alkenyl of said 2-heteroalkenyl of the compound and CR.sup.2 when A is not bonded directly to said alkenyl of said 2-heteroalkenyI of the compound, R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen, halogen, cyano and lower alkyl having from 1 to 6 carbon atoms and the 9,11, or 15 alkyl esters thereof.