Patent ID: 6100422
Filing Date: 2000-08-08
Classification: C07K

Abstract:
A method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester (aspartame), comprising:preparing an aqueous solution of the aspartame;introducing the aspartame solution into a vessel having a first end and a second end at or near the first end thereof;introducing a coolant into a coolant passage having a first end and a second end at the second end thereof, the first end of coolant being located near the first end of the vessel, the second end being located near the second end of the vessel;flowing the coolant through the passage toward the first end thereof;flowing the aspartame solution toward at or near the second end of the vessel, the aspartame solution flowing in the vessel being in thermal contact with the coolant flowing through the passage, thereby the aspartame solution is cooled and the aspartame dissolved therein crystallizes; andobtaining aspartame slurry including aspartame crystals and remaining solution at or near the second end of the vessel.