Patent ID: 6528627
Filing Date: 2003-03-04
Classification: A61K,A61P,C07B,C07C,C07D,C07F

Abstract:
A compound of the formula: wherein:n=0 or 1; R1 and R2 are independently selected from hydrogen, &boxH;O, with the proviso that both are not &boxH;O, â€”(CH2)mâ€”Z where m is 0-10 and Z represents a conjugation group or targeting moiety, and â€”(CH2)mâ€”W where m is 0-10 and W represents a hydrolyzable group, or R1 and R2 are taken together with the carbon atoms to which they are attached to form a cyclic anhydride or when n=0 to form a benzene ring; R3 is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, â€”(CH2)mâ€”Z or â€”(CH2)mâ€”W; R4 and R5 are attached at one or more of the ring positions and are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, â€”(CH2)mâ€”Z and â€”(CH2)mâ€”W; R6 and R7 are independently selected from hydrogen with the proviso that both are not hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, â€”(CH2)mâ€”Z, â€”(CH2)mâ€”Wâ€” and where Q represents a multivalent acid functionality group able to coordinate with metal ions, and p=0 to 1; R12 and R13 are independently selected from hydrogen, hydroxyl, carboxyl, phosphoric, and hydrocarbon radicals having from 1-10 carbon atoms, and physiologically acceptable salts of the acid radicals; X, Xâ€², Y and Yâ€² are independently selected from carbon, oxygen and sulfur, wherein at least one is oxygen or sulfur, to independently form 5 or 6 member aromatic rings wherein the remaining ring atoms are carbon; A and Aâ€² are independently selected from sulfur, nitrogen and oxygen, where sulfur may bear a hydrogen or a sulfur protecting group; where an oxygen or a nitrogen may bear a hydrogen; or where A or Aâ€² is nitrogen, A may bear R8 or R10 or both and Aâ€² may bear R9 or R11 or both, wherein R8, R9, R10 and R11 are independently selected from lower alkyl, alkoxy, halogen, hydroxyl, nitro, â€”(CH2)mâ€”Z, â€”(CH2)mâ€”W and â€ƒor R8 and R10 may be joined together to form a cyclic anhydride that is attached to A only or R9 and R11 may be joined together to form a cyclic anhydride that is attached to Aâ€² only; and the compound has at least one Z, W or Q.