Patent ID: 8900576
Filing Date: 2014-12-02
Classification: A61K,A61P,C12Y

Abstract:
1. A method for treating burns of varying depth, pressure sores, vascular ulcers or diabetic foot ulcers, and wounds by the enzymatic debridement for eschar removal which comprises administering a pharmaceutical composition comprising hyaluronic acid or at least one hyaluronic acid derivative and the proteolytic enzyme collagenase, wherein said collagenase is from the non-pathogenic micro-organism belonging to the strain Vibrio Alginolyticus sub. Iophagus , said hyaluronic acid derivative is at least one member selected from the group consisting of salts of hyaluronic acid with organic and/or inorganic bases, amides, sulphatated derivatives, deacetylated derivatives and percarboxylated derivatives, the concentration of the proteolytic enzyme collagenase is between 0.01 U and 100 U/milligrams of said hyaluronic acid or said hyaluronic acid derivative, said hyaluronic acid or said hyaluronic acid derivative is present in a concentration of between 0.01 and 5% weight/weight of the composition and wherein said hyaluronic acid or the hyaluronic acid used in the preparation of said at least one hyaluronic acid derivative has a molecular weight of between 50 kDa and 200 kDa.