Patent ID: 8323645
Filing Date: 2012-12-04
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal antibody or antigen-binding fragment, wherein the antibody or antigen-binding fragment comprises: (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) comprising the following amino acid sequences: HCDR1: SEQ ID NO:19, HCDR2: SEQ ID NO:20, and HCDR3: SEQ ID NO:21; and (b) three light chain complementarity determining region (LCDR1, LCDR2 and LCDR3) comprising the following amino acid sequences: LCDR1: SEQ ID NO:28, LCDR2: SEQ ID NO:29, and LCDR3: SEQ ID NO:30.