Patent ID: 6296893
Filing Date: 2001-10-02
Classification: A61L,A61M

Abstract:
A method of making a pharmaceutical packing device comprising an extended hollow plastic body (1) having an axial length (I) and a cylindrical portion (7) extending over at least a part of said axial length of said plastic body (1) and an interior silicone lubricant layer (3) provided in said cylindrical portion (7); wherein said hollow plastic body (1) is formed so as to be closed by means of a stopper (4); said method comprising the steps of:a) forming the hollow plastic body by an injection molding technique, said hollow plastic body consisting of a cycloolefin copolymer;b) preparing a mixture of reactive silicone oil and non-reactive silicone oil so that said mixture contains from 5 to 85 percent by weight of said non-reactive silicone oil;c) applying said mixture prepared in step b) in a single application step to an interior surface in said cylindrical portion of the hollow plastic body immediately after said forming of step a) when said hollow plastic body has a temperature of at least 40.degree. C. to form a preliminary layer, said applying being performed without activating the interior surface prior to the applying; andd) cross-linking said reactive silicone oil in the preliminary layer to form said silicone lubricant layer, said silicone lubricant layer consisting of an adherent base layer in which the non-reactive silicone oil is locally embedded.