Patent ID: 8039218
Filing Date: 2011-10-18
Classification: C12Q

Abstract:
1. A method of predicting melanoma recurrence in a subject and relapse-free survival of a subject, comprising: obtaining a body fluid from a first subject; and detecting the expression of a panel of genes in the body fluid, the panel of genes including PAX-3, GalNac-T, MAGE-A3, and MART-1, wherein, as compared to the number of the expressed genes selected from the group consisting of PAX-3, GalNac-T, MAGE-A3, and MART-1 in a body fluid obtained from a second subject, a higher number of the expressed genes selected from the group consisting of PAX-3, GalNac-T, MAGE-A3, and MART-1 in the body fluid obtained from the first subject indicates that the first subject has a higher probability of melanoma recurrence, and wherein, as compared to the expression of one or no gene selected from the group consisting of PAX-3, GalNac-T, MAGE-A3, and MART-1 in a body fluid obtained from a second subject, the expression of at least two genes selected from the group consisting of PAX-3, GalNac-T, MAGE-A3, and MART-1 in the body fluid obtained from the first subject indicates that the first subject has a likelihood of a shorter relapse-free survival.