Patent ID: 8673334
Filing Date: 2014-03-18
Classification: A61L,A61P,C08L,C09D

Abstract:
1. A medical article comprising an implantable substrate and a coating, the coating comprising: a bulk polymer selected from a group consisting of a poly(meth)acrylate, a vinyl polymer, a halogenated polymer, and a polymer having urethane groups; an additive polymer in less quantity in the coating than the bulk polymer, the additive polymer being entangled with the bulk polymer; and a drug; wherein the bulk polymer has an equilibrium water adsorption less than about 10 mass % at room temperature; wherein the poly(meth)acrylate is poly(n-propyl methacrylate), poly(iso-propyl methacrylate), poly(n-propyl acrylate), poly(iso-propyl acrylate), poly(n-butyl acrylate), poly(iso-butyl acrylate), or a mixture thereof; wherein the vinyl polymer is poly(ethylene-co-vinyl acetate), poly(styrene-co-iso-butylene), poly(styrene-co-ethylene-co-butylene-co-styrene) terpolymer, poly(styrene-co-butadiene-co-styrene) terpolymer, or a mixture thereof; wherein the halogenated polymer is poly(vinyl fluoride), poly(vinylidene fluoride), polyhexafluoropropene, poly(hexafluoropropene-co-vinylidene fluoride), poly(ethylene-co-hexafluoropropene), poly(vinyl chloride), poly(vinylidene chloride), or a mixture thereof; wherein the polymer having urethane groups is a polyurethaneurea, a silicone urethane, or a mixture thereof; wherein the additive polymer is chondroitan sulfate, a glucosaminoglucan, dextrin, dextran sulfate, or a mixture thereof, or poly(trimethylene glycol), poly(tetramethylene glycol), or a mixture thereof; and wherein the ratio of the bulk polymer to the additive polymer is about 74:1 to about 14:1.