Patent ID: 6413991
Filing Date: 2002-07-02
Classification: A61K,A61P,C07D

Abstract:
A compound of the Formula II wherein:X1 is â€”OCH2â€”, â€”SCH2â€”, or a bond; X3 is O, S, or a bond; R2 is independently hydrogen, C1-C4 alkyl, or aryl; R3 is hydrogen or C1-C4 alkyl; R4 is a moiety selected from the group consisting of: X2 is a bond, or a 1 to 5 carbon straight or branched alkylene; R5 is hydrogen or C1-C4 alkyl; R6 is hydrogen, C1-C4 alkyl, or CO2(C1-C4 alkyl); or R5 and R6 combine with the carbon to which each is attached to form a C3-C6 cycloalkyl; or R6 combines with X2 and the carbon to which each is attached to form a C3-C8 cycloalkyl; or R6 combines with X2, R4, and the carbon to which each is attached to form: â€ƒprovided that R5 is hydrogen; R7 is independently hydrogen, halo, hydroxy, OR2, C1-C4 alkyl, C1-C4 haloalkyl, aryl, COOR2, CONHR2, NHCOR2, C1-C4 alkoxy, NHR2, SR2, CN, SO2R2, SO2NHR2, or SOR2; R8 is independently hydrogen, halo or C1-C4 alkyl; R9 is halo, CN, OR10, C1-C4 alkyl, C1-C4 haloalkyl, CO2R2, CONR11R12, CONH(C1-C4 alkyl or C1-C4 alkoxy), SR2, CSNR2, CSNR11R12, NR2SO2R2, SO2R2, SO2NR11R12, SOR2, NR11R12, optionally substituted aryl, or C2-C4 alkenyl substituted with CN, CO2R2 or CONR11R12; R10 is C1-C4 alkyl, C1-C4 haloalkyl, (CH2)nC3-C8 optionally substituted cycloalkyl, (CH2)n optionally substituted aryl or (CH2)nCO2R2; R11 and R12 are independently hydrogen, C1-C4 alkyl, aryl, or (CH2)naryl; m is 0 or 1; n is independently 0, 1, 2, or 3; or a pharmaceutically acceptable salt or solvate thereof; provided that if R4 is a moiety selected from the group consisting of: then:R9 is CN, OR10, C1-C4 haloalkyl, CO2R2, CONH(C1-C4 alkyl or C1-C4 alkoxy), CSNR2, CSNR11R12, NR2SO2R2, SO2NR11R12, NR11R12, optionally substituted aryl, or C2-C4 alkenyl substituted with CN, CO2R2 or CONR11R12; and â€ƒR10 is C1-C4 haloalkyl, (CH2)nC3-C8 optionally substituted cycloalkyl, (CH2)n substituted aryl, or (CH2)nCO2R2.