Patent ID: 8039470
Filing Date: 2011-10-18
Classification: A61P,C07D,C12Q

Abstract:
1. A method of treating a disease or disease symptom modulated by any one or any combination of the kinases selected from VEGFR, PDGFR, KIT, and Flt-3, in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I), wherein Cy is a cyclic structure that can be cycloalkyl or heterocyclic, each optionally substituted with Z R (1) hydrogen or R (2) —OH or —OR (3) —SH or —SR (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) —Z (12) —P(O)(OR R (1) hydrogen or R (2) R (3) any two of R Z (1) hydrogen or Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z (13) any two of Z Z (1) a single bond; (2) —Z (3) —Z (4) —Z (5) —Z (6) —Z (7) —Z Z (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; each Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z each Z each Z each Z each Z each Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z where Z where any two of Z provided said compound is other than a compound of formula IIa or IIb or pharmaceutical salt thereof; wherein the disease or disease symptom is renal cell carcinoma or GI stroma tumor.