Patent ID: 6174887
Filing Date: 2001-01-16
Classification: A61K,A61P,C07C,C07D,Y02P

Abstract:
An amide compound of the formula (I): ##STR179##wherein;R is a piperazinyl optionally substituted by lower alkyl, a piperidyl optionally substituted by lower alkyl or an aminowherein amino is optionally substituted by lower alkyl;A is a linear alkylene;X is an oxygen atom, a sulfur atom, --NH-- or --CH.sub.2 --;M is an arylene;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each is a hydrogen atom, provided at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is not a hydrogen atom, a hydroxy, a halogen atom, or --O--CO--R.sup.11 ""' wherein R.sup.11 ""' is lower alkyl optionally substituted by a substituent selected from the group consisting of amino, acyloxy and benzyloxycarbonyl, or phenyl optionally substituted by lower alkyl;R.sup.5 is a hydrogen atom;m is 1;R.sup.6 is a phenyl andR.sup.7 is --COO--R.sup.12 '""wherein R.sup.12 '"" is hydrogen atom, aralkyl, adamantyl, cyclohexylideneamino,cyclohexyl optionally substituted by lower alkyl, piperidyl optionally substituted by lower alkyl, or alkyl optionally substituted by a substituent selected from the group consisting of hydroxy, lower alkoxy, lower alkoxy lower alkoxy, lower alkoxycarbonyl, acyloxy, piperazinyl and amino optionally substituted by lower alkyl;or a pharmaceutically acceptable acid addition salt thereof.