Patent ID: 6414026
Filing Date: 2002-07-02
Classification: A61K,A61P

Abstract:
A method of alleviating a fibrotic disease selected from lung fibrosis and liver cirrhosis in a warm blooded animal, which comprises administering an effective amount of at least one compound having the formula (I) in which X stands for the oxygen or sulphur atom or for the imino (â€”NHâ€”) or sulphonyl (â€”SO2â€”) radical, Y stands for a direct linkage, or for the oxygen or sulphur atom or for the sulphonyl (â€”SO2â€”) radical or for the radical of the formula â€”CR1R2â€”, wherein R1 and R2 which may be the same or different are hydrogen, alkyl or aryl radicals or R1 and R2 may be joined together to form a cycloalkyl ring, and ring B may be optionally substituted by one or more substituents selected from halogen atoms and alkyl and aryl radicals, when n is an integer having the value 1, or Y stands for the oxygen or sulphur atom or for the sulphonyl (â€”SO2â€”) radical, and ring B may be optionally substituted by one or more substituents selected from halogen atoms and alkyl and aryl radicals when n has the value 0, or an ester, amide or salt thereof.