Patent ID: 7960343
Filing Date: 2011-06-14
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method for decreasing follicle-stimulating hormone (FSH) levels in a human subject, the method comprising administering to a subject in need thereof an amount of an activin receptor type IIa-immunoglobulin Fc domain (ActRIIa-Fc) fusion protein effective to reduce FSH levels in the subject, wherein the ActRIIa-Fc fusion protein comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3, wherein the amount administered results in an ActRIIa-Fc serum concentration of at least 1000 ng/mL, and wherein the ActRIIa-Fc fusion protein binds to activin.