Patent ID: 6534282
Filing Date: 2003-03-18
Classification: C12Q,G01N,Y10S,Y10T

Abstract:
A method for assessing hypertension in a mammal comprising the steps of only measuring an amount of of free and conjugated dihydroxyeicosatrienoic acids and their metabolites of arachidonic acid converted to dihydroxyeicosatrienoic acid metabolites by both arachidonic acid (AA) epoxygenases and soluble epoxide hydrolases, in a first biological sample; comparing the amount of the free and conjugated dihydroxyeicosatrienoic acids and their metabolites to a second sample from a non-hypertension mammal of a same species and determining if the first mentioned sample contains a comparatively elevated amount of the free and conjugated dihydroxyeicosatrienoic acids and their metabolites as an indication of hypertension mediated by the epoxygenases and epoxide hydrolases.