Patent ID: 8613954
Filing Date: 2013-12-24
Classification: A61J,A61K,A61P,B82Y,C07C,Y10S

Abstract:
1. A therapeutic nanoparticle comprising: about 4 to about 25 weight percent of a taxane agent; about 10 to about 99 weight percent of a diblock poly(lactic) acid -poly(ethylene)glycol copolymer comprising poly(lactic) acid having a number average molecular weight of about 15 to 20 kDa, and poly(ethylene)glycol having a number average molecular weight of about 4 to 6 kDa; wherein the hydrodynamic diameter of the therapeutic nanoparticle is about 60 nm to about 140 nm; and wherein the therapeutic nanoparticle releases less than 10% of the taxane agent when placed in a phosphate buffer solution at room temperature for about 1 minute.