Patent ID: 6641833
Filing Date: 2003-11-04
Classification: A61K,A61P,Y10S

Abstract:
A biodegradable polymer composition suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer, said composition comprising:(a) paclitaxel and (b) a biodegradable polymer comprising the recurring monomeric units shown in formula VI: wherein the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and n is about 5-5,000; wherein said polymer composition provides extended release of said antineoplastic agent into the peritoneum of said subject; and wherein said polymer composition increases the median survival rate of said mammalian subject from said cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of said antineoplastic agent without said biodegradable polymer.