Patent ID: 8283463
Filing Date: 2012-10-09
Classification: A61K,A61L,A61P,C08B

Abstract:
1. A process for sterilizing a solution, the process comprising: providing an aqueous solution of hyaluronic acid having a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight; wherein the aqueous solution has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight to provide a high salt, hyaluronic acid solution; maintaining the aqueous high salt, hyaluronic acid solution at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days; and filtering the heated, high salt, hyaluronic acid solution through a sterilization filter medium, wherein the filter medium has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.