Patent ID: 6660773
Filing Date: 2003-12-09
Classification: C07C,C07D

Abstract:
A process for preparing N-(4-methoxyphenyl)-3-chloropropionamide comprising the steps ofadding p-anisidine and from about 1 to 1.2 equivalents of sodium bicarbonate, with respect to the p-anisidine, to toluene to form a suspension of sodium bicarbonate in a p-anisidine solution, adding from about 0.9 to about 1.1 equivalents of 3-chloropropionyl chloride to the suspension, with respect to the p-anisidine, maintaining the temperature of the suspension at from about 25Â° C. to about 111Â° C. for a period of time sufficient to cause substantially all of the p-anisidine to be converted to N-(4-methoxyphenyl)-3-chloropropionamide, quenching the mixture with aqueous mineral acid, wherein quenching causes precipitation of a solid, and washing the solid with water and toluene, yielding a washed solid that is N-(4-methoxyphenyl)-3-chloropropionamide in greater than 98% purity, and wherein the purity is obtained without requiring recrystallizing the N-(4-methoxyphenyl) -3-chloropropionamide.