Patent ID: 6498164
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A method of treating diseases of bones and cartilage in warm-blooded animals comprising administering to warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula wherein R and R1 are individually selected from the group consisting of unsubstituted or substituted alkyl and alkenyl of 3 to 15 carbon atoms and unsubstituted or substituted arylmethyl, R2 is 2-thienylmethyl and unsubstituted or substituted arylmethyl, the substituents being at least one member of the group consisting of â€”OH, â€”NH2, alkoxy of up to 10 carbon atoms, alkylthio of up to 10 carbon atoms, mono- and dialkylamino, halogen, â€”CN, â€”NO2, alkylenedioxy, alkyl of up to 10 carbon atoms and aryl and its pharmaceutical salts sufficient to treat bone and cartilage disease.