Patent ID: 6710080
Filing Date: 2004-03-23
Classification: A61P,C07C,C07D

Abstract:
A substituted 2-dialkylaminoalkylbiphenyl compound of formula I whereinn is 1 or 2; R1, R2, R3, which are identical or different, represent H, F, Cl, Br, CN, NO2, CHO, SO2CH3, SO2CF3, OR6 in the 3â€² or 5â€² position, NR6R7, a C1-6-alkyl, an aryl, an acetyl, an acetamidyl or a benzoyl group or represent an aryl group bonded via a C1-6-alkylene group; or R1 and R2 together denote the group OCH2O, OCH2CH2O, CH&boxH;CHO, CH&boxH;C(CH3)O or CH&boxH;CHNH; R4, R5, which are identical or different, represent a C1-6-alkyl group; R6, R7, which are identical or different, represent H, a C1-6-alkyl or an aryl group, or represent an aryl group bonded via a C1-6-alkylene group; or a physiologically tolerated salt, provided that the compounds: 2â€²-dimethylaminomethylbiphenyl-2-carbaldehyde; biphenyl-2-ylmethyldimethylamine; 2â€²-dimethylaminomethylbiphenyl-2-ol, and the corresponding hydrochloride; (2â€²,3â€²-dimethoxybiphenyl-2-ylmethyl)dimethylamine, and the corresponding hydrochloride and hydrobromide; (4â€²-methylbiphenyl-2-ylmethyl)-dimethylamine; (2â€²-methylbiphenyl-2-ylmethyl)-dimethylamine; (4)-chloro-2â€²-dimethylaminomethylbiphenyl-2-carbonitrile; (2â€²-dimethylaminomethylbipheny-2-yl)methanol; 2â€²-dimethylaminomethylbiphenyl-2,3-diol, and the corresponding hydrobromide; [2-(3â€²,4â€²-dimethoxybiphenyl-2-yl)ethyl)]-dimethylamine, and the corresponding hydrochloride; [2-(2â€², 3â€²-dimethoxy-6â€²-methylbiphenyl-2-yl)ethyl)]-dimethylamine, and the corresponding hydrobromide; and biphenyl-2-ylethyldimethylamine are excluded.