Patent ID: 6204267
Filing Date: 2001-03-20
Classification: A61P,C07D,G01N

Abstract:
A quinazoline compound having a structure set forth in formulas VI or VII: ##STR18##wherein(a) R.sub.1 and R.sub.2 are independently selected form the group consisting of hydrogen and --NH.sub.2, provided at least one of R.sub.1 and R.sub.2 is --NH.sub.2 ;(b) R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 are independently selected from the group consisting of(i) hydrogen,provided that at least one of R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 is a non-hydrogen moiety if R.sub.2 is --NH.sub.2 ;(ii) saturated or unsaturated alkyl,provided that when R.sub.2 is --NH.sub.2, then R.sub.8 is not methyl, propyl, isopropyl, t-butyl, 1,1-dimethylpropyl, or n-hexyl;(iii) NX.sub.2 X.sub.3, where X.sub.2 and X.sub.3 are independently selected from the group consisting of hydrogen and saturated or unsaturated alkylprovided that when R.sub.2 is --NH.sub.2, then X.sub.2 and X.sub.3 are not both hydrogen or ethyl;(iv) halogen,provided that only one R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 is a halogen, also provided that when R.sub.2 is --NH.sub.2, then R.sub.8 is not chlorine, bromine, or fluorine, and when R.sub.2 is --NH.sub.2, then R.sub.6 and R.sub.7 are not chlorine;(v) trihalomethylprovided that when R.sub.2 is --NH.sub.2, then R.sub.8 is not trifluoromethyl; and(vi) OX.sub.9, where X.sub.9 is selected from the group consisting of hydrogen, saturated or unsaturated alkyl, and a five-membered or six-membered heteroaryl or six-membered aryl ring moietyprovided that when R.sub.2 is --NH.sub.2, then R.sub.8 is not hydroxy or methoxy,also provided that when R.sub.2 is --NH.sub.2, then R.sub.6 or R.sub.7 are not each methoxy.