Patent ID: 6201021
Filing Date: 2001-03-13
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for treating diseases induced by reactive astrocytes, which comprises administering an effective amount of a compound of the formula (X): ##STR223##wherein n is 0 or 1;R.sup.11 is hydrogen or chlorine;R.sup.5 is R.sup.7 --CH.sub.2 -- or R.sup.8, orR.sup.5 and R.sup.11, taken together, form C3-10 alkylidene;R.sup.7 is F--(CH.sub.2).sub.m --, in which m is 4-6,F.sub.3 C--CH.sub.2 --, C2-10 alkyl substituted by 1 or 2 chlorines, or C1-5 alkyl substituted by 1 or 2 C1-4 alkoxy, C3-7 cycloalkyl, phenyl or phenoxy groups;R.sup.8 is(i) C3-10 alkyl,(ii) C3-10 alkenyl,(iii) C2-10 alkoxy,(iv) C2-10 alkylthio,(v) C3-7 cycloalkyl,(vi) phenyl or(vii) phenoxy;R.sup.6 is hydroxy,or non-toxic salts thereof or acid addition salts thereof.