Patent ID: 6632951
Filing Date: 2003-10-14
Classification: C07D

Abstract:
A method of making a compound having the formula: whereinR1, R2, R4, and R5 are, independently, H or a C1 to C6 alkyl or substituted alkyl; and R3 is H or a C1 to C6 alkyl or substituted alkyl; comprising a first step of reacting a composition comprising: a compound having the formula: whereinR1, R2, R4, and R5 are, independently, H or a C1 to C6 alkyl or substituted alkyl; or wherein R2 and R4 together are replaced by a double bond; R3 is H or a C1 to C6 alkyl or substituted alkyl; and X and Y are, independently, OH, Oâˆ’, or where X and Y together are a bridging oxo; and an ammonia source, in the presence of water, to form a compound having the formula: whereinR1, R2, R4, and R5 are, independently, H or a C1 to C6 alkyl or substituted alkyl; or wherein R2 and R4 together are replaced by a double bond; R3 is H or a C1 to C6 alkyl or substituted alkyl; a second step of extracting the compound of formula (A) into an organic solvent; and a third step comprising hydrogenating the compound of formula (A), that was extracted in the second step, in the presence of a catalyst.