Patent ID: 9102720
Filing Date: 2015-08-11
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting tumor angiogenesis comprising administering to a subject with cancer an effective amount of an isolated anti-vascular endothelial growth factor-C (VEGF-C) antibody, wherein the antibody comprises six HVRs: (1) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:3; (2) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:8; (3) an HVR-H3 comprising the amino acid sequence of SEQ ID NO:26; (4) an HVR-L1 comprising the amino acid sequence of SEQ ID NO:27; (5) an HVR-L2 comprising the amino acid sequence of SEQ ID NO:28; and (6) an HVR-L3 comprising the amino acid sequence of SEQ ID NO:29.