Patent ID: 9221828
Filing Date: 2015-12-29
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a pharmaceutically acceptable salt thereof: wherein Ar is selected from the series consisting of phenyl and a 5-membered or 6-membered monocyclic aromatic heterocycle comprising 1, 2 or 3 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur and bonded via a ring carbon atom, which are all unsubstituted or substituted by one or more identical or different substituents R10; n is selected from the series consisting of 0, 1 and 2; R1 is selected from the series consisting of hydrogen, —N(R11)-R12, —N(R13)-C(O)—R14, —N(R13)-S(O) R2 is selected from the series consisting of halogen, —(C R10 is selected from the series consisting of halogen, (C R11 and R12 are independently of one another selected from the series consisting of hydrogen, (C R13 is selected from the series consisting of hydrogen, (C R14 and R15 are independently of one another selected from the series consisting of (C R16 is selected from the series consisting of hydrogen, (C R17 is selected from the series consisting of hydrogen, (C R18 is selected from the series consisting of hydrogen and (C R19 is selected from the series consisting of hydrogen, (C R20 is selected from the series consisting of hydrogen, (C or R19 and R20, together with the nitrogen atom carrying them, form a monocyclic, 4-membered to 7-membered, saturated heterocycle which, in addition to the nitrogen atom carrying R19 and R20, comprises 0 or 1 further ring heteroatom selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more identical or different substituents selected from the series consisting of fluorine and (C R21 is selected from the series consisting of hydrogen, (C R22 is selected from the series consisting of (C R23 and R24 are independently of one another selected from the series consisting of hydrogen and (C R30 is selected from the series consisting of halogen, (C Het is a monocyclic, 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocycle which comprises 1 or 2 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, and which is bonded via a ring carbon atom; wherein all cycloalkyl groups can be substituted by one or more identical substituents selected from the series consisting of fluorine and (C wherein all alkyl groups, independently of any other substituents which can be present on an alkyl group, can be substituted by one or more fluorine substituents.