Patent ID: 7276507
Filing Date: 2007-10-02
Classification: A61K,A61P,C07D

Abstract:
1. A pyrido[2,3-b]pyrazine compound of general Formula I in which the substituents R1-R4 have the following meaning: R1 and R2 are independently of one another: (i) hydrogen, (ii) hydroxyl, (iii) halogen, (iv) allyl, where the alkyl radical is saturated and may consist of 1 to 8 C atoms, (v) unsubstituted or substituted aryl, where the aryl radical may have one or more identical or different F, Cl, Br, I, CF (vi) unsubstituted or substituted heteroaryl, where the heteroaryl radical may have one or more identical or different F, Cl, Br, I, CF (vii) OR5, where R5 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents can, for their part, in turn be substituted, (viii) SR6, where R6 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents can, for their part, in turn be substituted, (ix) NR7R8, where R7 and R8 are, independently of each other, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcyclyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents can, for their part, in turn be substituted,  or R7 and R8 are together cycloalkyl or heterocyclyl, where the cycloalkyl and heterocyclyl can, for their part, in turn be substituted; R3 and R4 are, independently of each other, hydrogen or NR9R10 with the proviso that, when R3=NR9R10, R4=H and when R4=NR9R10, R3=H, and R3 and R4 are not both H or NR9R10 at the same time, where R9 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents can, for their part, in turn be substituted, and R10 is: A, B, or C, where (A) is: —C(Y)NR11R12, where Y is O, or S and R11 and R12 are independently of one another (B) is —C(Y)NR13R14, where Y is NH and R13 and R14 are independently of one another (C) is —C(NR15)R16 where R15 is H and R16 is and physiologically tolerable salts, hydrates thereof, and where the compound of the general Formula I and the physiologically tolerable salts and hydrates thereof are present in the form of their racemates, in the form of their pure enantiomers and/or diastereomers or in the form of their tautomers or in the form of mixtures of these enantiomers and/or diastereomers.