Patent ID: 8273325
Filing Date: 2012-09-25
Classification: A61K

Abstract:
1. A compound of formula I having affinity for proteoglycans, and pharmaceutically acceptable salts thereof wherein C represents a core unit linked to the L units and to the S unit when S is present or to the R moiety when S is not present, and which comprises amino acid residues selected from the group consisting of lysine, ornithine, and diaminopropionic acid, and optionally an amine; L is the same or different and represents a bifunctional linker unit comprising a PEG linker, wherein said PEG linker is of formula (II) wherein q equals an integer from 1 to 10 and which binds to the carboxy and the amino entities of amino acids; or said PEG linker is of formula: P is the same or different and represents a positively charged peptide unit comprising 2 to 8 positive charges and 2 to 20 amino acids, wherein at least one amino acid contains a guanidine group; S represents a spacer unit; R represents an imaging moiety comprising an imaging entity selected from the group consisting of: (i) a radioactive metal ion; (ii) a paramagnetic metal ion; (iii) a gamma-emitting radioactive halogen; (iv) a positron-emitting radioactive non-metal; (v) a hyperpolarised NMR-active nucleus; (vi) a reporter suitable for in vivo optical imaging; and (vii) a β-emitter suitable for intravascular detection; p represents an integer of 0 or 1; and n represents an integer from 1 to 16.