Patent ID: 9096568
Filing Date: 2015-08-04
Classification: C07C,C07D

Abstract:
1. A process for preparing a compound of formula (III) in which Ar is a group, where R the Ar radical may additionally also be a heteroaromatic radical or the Ar radical may also be 1- or 2-naphthyl, and R where R wherein an aryl or heteroaryl halide of formula (I) in which Hal is chlorine, bromine or iodine and Ar is as defined above, is reacted with a malonic ester of formula (II) in the presence of a palladium catalyst, of a phosphine ligand and of an inorganic base and of a phase transfer catalyst optionally using an organic solvent wherein the phase transfer catalyst comprises a quaternary ammonium salt or phosphonium salt of formula (V) in which R A is N or P and X is halogen, hydrogensulphate, sulphate, dihydrogenphosphate, hydrogenphosphate, phosphate or acetate; or a crown ether of formula (VI) in which n is a number from 4 to 8 and the R