Patent ID: 6218375
Filing Date: 2001-04-17
Classification: A61K,A61P,B82Y,Y10S

Abstract:
A ras-farnesyltransferase inhibitor complex comprising the ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof ##STR4##wherein n is 0 or 1; R.sub.1 is Cl, Br, phenyl, pyridyl or cyano; R.sub.2 is aralkyl; R.sub.3 is lower alkyl, aryl, substituted aryl or heterocyclo; Z.sub.1 is CO, SO.sub.2, CO.sub.2, or SO.sub.2 NR.sub.5, R.sub.5 is hydrogen, lower alkyl or substituted alkyl; and sulfobutylether-7-.beta.-cyclodextrin or 2-hydroxypropyl-.beta.-cyclodextrin in a molar ratio of the inhibitor to sulfobutylether-7-.beta.-cyclodextrin or 2-hydroxypropyl-.beta.-cyclodextrin of within the range of from about 1 to 2 or higher.