Patent ID: 6692753
Filing Date: 2004-02-17
Classification: A61K,A61P,G01N,Y02A

Abstract:
A method for stimulating proliferation of T-cells in a patient infected with HIV, said method comprising administering to said patient an organic compound having the structure: whereinB is boron, D1 and D2 are each independently selected from the group consisting of a hydroxyl group and a group that is capable of being hydrolyzed to a hydroxyl group in aqueous solution at physiological pH; and X comprises an amino acid or a peptide which mimics the site of a substrate recognized by a post-prolyl cleaving enzyme; wherein said compound is further characterized in that:(a) it inhibits T-cell cytoplasmic post-prolyl cleaving dipeptidase activity at a concentration above 10âˆ’8 M, and (b) it is capable of crossing the membrane of T-cells of said patient to enter the cytoplasm, wherein said compound is administered to said patient so that its concentration in the blood of said patient does not exceed 10âˆ’8 M.