Patent ID: 6716395
Filing Date: 2004-04-06
Classification: C40B,G01N,Y10T

Abstract:
An apparatus for screening a proteome, comprising:a) an array of affinity elements, said affinity elements including at least one ligand and said at least one ligand being bound to a compound of the proteome; b) a means for applying a centrifugal force to the array whereby a flow of eluent can be directed through the array by centrifugal force and can release the compound of the proteome that is bound to the at least one ligand, thereby eluting the compound of the proteome from the array as a component of an eluate for screening of the proteome; c) at least one swing basket supporting the array, said swing basket including a hinge, whereby rotation of the swing basket about an axis causes the swing basket to rotate about the hinge, thereby causing the centrifugal force on the array to be parallel to the flow of eluent through the affinity elements of the array; d) at least one tube sheet having a plurality of tube elements positioned between the hinge and the array, the plurality of tube elements aligned with the affinity elements of the array, the tube sheet being moveable laterally relative to the flow of eluent from the tube sheet through the affinity elements of the array; e) a plurality of orifices, defined by the tube sheet and heated between at least a portion of the tube elements of the tube sheet; and f) a moveable set of collection tubes aligned with the affinity elements of the array, the set of collection tubes being positioned on a side of the array opposite to that of the tube sheet to contain the eluate.