Patent ID: 6630171
Filing Date: 2003-10-07
Classification: A61K,A61Q,Y10S

Abstract:
A composition comprising particles of amphiphilic, linear polyaminoacids (PAAs) having &agr;-peptide chains of recurrent aminoacids (rAAs), wherein:said particles having a mean particle size of less than 200 &mgr;m; said particles being spontaneously obtainable by bringing the PAAs into contact with an aqueous liquid medium, in which the hydrophilic portion of the PAAs solubilizes more than the hydrophobic portion of said PAAs, such that the latter precipitate while becoming organized in discrete supramolecular arrangements and so forming spontaneously colloidal suspensions of particles compatible with the pH of physiological media; said particles being capable of spontaneous association with at least one active principle (AP) in an aqueous medium; said particles associated with at least one AP being capable of releasing the AP in vivo, under physiological conditions, in a sustained and controlled way; all the rAAs being selected from the group consisting of aspartates and glutamates; said rAAs being identical to or different from one to another; some of said rAAs bearing at least one hydrophobic R0 group which, when more than one R0 group is present on the rAA, may be identical or different.