Patent ID: 8518446
Filing Date: 2013-08-27
Classification: A61K,A61P

Abstract:
1. A pharmaceutically acceptable composition comprising: a granulation comprising intragranular components: (a) 10-70 weight percent neratinib maleate; (b) 15-65 weight percent of one or more fillers; (c) 0-8 weight percent of one or more disintegrants; (d) 0.2-8 weight percent of one or more glidants; and (e) 5-15 weight percent of one or more surface modifying agents; wherein the granulation is combined with extragranular components: (f) 1-25 weight percent of one or more fillers; (g) 0-8 weight percent of one or more disintegrants; and (h) 0.1-3 weight percent of one or more lubricants.