Patent ID: 6541615
Filing Date: 2003-04-01
Classification: A61K,C07K,C12N,Y02A

Abstract:
An isolated, enriched or purified nucleic acid molecule comprising a nucleotide sequence that(a) encodes a polypeptide having the full length amino acid sequence set forth in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, or SEQ ID NO: 8; (b) is the complement of the nucleotide sequence of (a); or (c) hybridizes under highly stringent conditions to the nucleotide molecule of (a) and encodes a naturally occurring SIRP polypeptide of at least 160 contiguous amino acids of the full-length sequence wherein said highly stringent conditions are at least as stringent as 50% formamide, 5Ã—SSC (0.75 M NaCl, 0.075 M Sodium pyrophosphate, 5Ã—Denhardt's solution, sonicated salmon sperm DNA (50 g/mL), 0.1% SDS, and 10% dextran sulfate at 42Â° C., with washes at 42Â° C. in 0.2Ã—SSC and 0.1% SDS; and wherein said polypeptide binds to a receptor tyrosine kinase or a SH-2 domain bearing protein.