Patent ID: 8586719
Filing Date: 2013-11-19
Classification: A61K,A61P,C07C,C07H,Y02A

Abstract:
1. A method for treating parasites in a subject, comprising contacting said subject with an effective amount of compound, or its salt, or ester thereof, wherein the parasitics comprise leishmaniases, amoebiasis, trypanosomiasis, toxoplasmosis or malaria; wherein the compound is selected from the following: a) A compound having structure Xanifolia(Y), or chemical name: 3-O-[β-D-galactopyranosyl (1→2)]-α-L-arabinofuranosy (1→3)-β-D-glucuronopyranosyl-21,22-O-diangeloyl-3β, 15α, 16α, 21 β, 22α, 28-hexahydroxyolean-12-ene; b) A compound having structure Xanifolia (Y1), or chemical name: 3-O-[β-D-galactopyranosyl (1→2)]-α-L-arabinofuranosyl (1→3)-β-D-glucuronopyranosyl-21-O-(3,4-diangeloyl)-α-L-rhamnophyranosyl-22-O-acetyl-3β,16α, 21β, 22α, 28-pentahydroxyolean-12-ene; c) A compound having structure Xanifolia (Y2), or chemical name: 3-O-[β-D-glucopyranosyl-(1→2)]- α-L-arabinofuranosy (1→3) -β-D-glucuronopyranosyl-21, 22-O-diangeloyl-3β, 15α, 16α, 21β, 22α, 24β, 28-heptahydroxyolean-12-ene; d) A compound having structure Xanifolia (Y8), or chemical name: 3-O- [β-glucopyranosyl (1→2) ]-α-arabinofuranosyl (1→3) -β-glucuronopyranosyl-21, 22-O-diangeloyl-3β, 16α, 21β, 22 α, 24β, 28-hexahydroxyolean-12-ene; e) A compound having structure Xanifolia (Y9), or chemical name: 3-O-[β-galactopyranosyl (1→2) ]-α-arabinofuranosyl (1→3) -β-glucuronopyranosyl-21-O- (3, 4-diangeloyl) -α-rhamnopyranosyl-28-O-acetyl-3β, 16α, 21β, 22α, 28-pentahydroxyolean-12-ene; and f) A compound having structure Xanifolia (Y10) , or chemical name: 3-O- [β-galactopyranosyl (1→2) ]-α-arabinofuranosyl (1→3) -β-glucuronopyranosyl-21, 22-O-diangeloyl-3 β, 16α, 21 β, 22α, 28-pentahydroxyolean-12-ene, g) A compound having structure Xanifolia (Y0), or chemical name: 3-O-[β-D-galactopyranosyl(1→2)]-α-L-arabinofuranosyl(1→3)-β-D-glucuronopyranosyl-21-O-angeloyl, 22-O-(2-methylpropanoyl)-3β, 15α, 16α, 21β, 22α, 28-hexahydroxyolean-12-ene, h) A compound having structure Xanifolia (X), or chemical name: 3-O-{[β-galactopyranosyl (1→2)]-[α-L-arabinofuranosyl (1→3)]-β-D-glucuronopyranoside butyl ester}-21-O-acetyl-22 -O-angeloyl-3β,16 α,21β,22α,28-pentahydroxyolean-12-ene, i) A compound having structure (Y7), or chemical name: 3-O-[O-D-galactopyranosyl-(1→2)]-α-L-arabinofuranosyl-(1→3)-β-D-glucuronopyranosyl-21-O-angeloyl-28-O-2-methylbutanoyl-3β, 15 α, 16α, 21β, 22α, 28-hexahydroxyolean-12-ene; j) A compound having structure (ACH-Y): k) A compound having structure: or chemical name: 3-O- [β-glucopyranosyl (1→2) ]-β-arabinofuranosyl (1→4) -β-glucuronopyranosyl-21-O-angeloyl-22-O-acteyl-3β, 16 α, 21β, 22α, 24β, 28-hexahydroxyolean-12-ene; l) A compound having structure (Y5): m) A compound having structure: wherein R1and R2are O(C═O)C(CH3)═CH(CH3), R3 is OH, and R4 is OH; (n) A compound having structure (ACH-Mb5): (o) A compound having structure (Ba 1): 3-O-[β-D-galactopyranosyl(1→2)]-β- D-xylopyranosyl (1→3) -β-D-glucuronopyranosyl-21-O-angeloyl, 22-O-angeloyl-3β, 15α, 21β, 22α, 28-pentahydroxyolean-12-ene, named Ba 1; and (p) A compound having structure (Z12): 3-O-[β-D-galactopyranosyl(1→2)]-β-D-xylopyranosyl (1→3)-β-D-glucuronopyranosyl-21-O-angeloyl, 22-O-tigloyl-3β, 16α, 21β, 22α, 28-pentahydroxyolean-12-ene.