Patent ID: 6174922
Filing Date: 2001-01-16
Classification: C07C,C07D

Abstract:
A compound of the formula: ##STR197##in which:A represents CR.sup.5 (X.sup.1 R.sup.6) or C.dbd.NO(CH.sub.2).sub.n R.sup.7 ;R.sup.1 represents hydrogen, or together with R.sup.5 a bond;R.sup.2 and R.sup.3 each independently represents hydrogen or (1-4C)alkyl, or together with the carbon atom to which they are attached form a (3-6C)cycloalkyl ring;R.sup.4 represents (1-6C)alkyl, (3-6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1-6C)alkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, (1-4C)alkylphenyl wherein the phenyl group is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or NR.sup.9 R.sup.10 in which each of R.sup.9 and R.sup.10 independently represents (1-4C)alkyl or together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group;;R.sup.5 represents hydrogen, hydroxy, (1-4C)alkoxy, (1-4C)alkoxycarbonyl, or together with a substituent on R.sup.6 a bond, or together with R.sup.1 a bond;X.sup.1 represents a bond, or when R.sup.1 represents hydrogen, NHCO;R.sup.6 represents (3-8C)cycloalkyl or an unsubstituted or substituted aromatic or heteroaromatic group;n is an integer of from 1 to 4; andR.sup.7 is as defined for R.sup.6 ;or a pharmaceutically acceptable salt thereof.