Patent ID: 8470842
Filing Date: 2013-06-25
Classification: A61K,A61P,C07B,C07D

Abstract:
1. A method of treating or delaying the onset of chemotherapy-induced nausea and/or chemotherapy-induced emesis in a mammal receiving chemotherapy which comprises administering to said mammal a medicament comprising a therapeutically effective amount of a crystalline Form I monohydrate hydrochloride salt form of the compound (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one (Formula I): wherein the crystalline Form I monohydrate hydrochloride salt form is characterized by an x-ray powder diffraction pattern including at least a strong peak having a diffraction angle (in 2θ) of 21.6±0.2 and lattice spacing (in Å) of 4.11±0.04.