Patent ID: 9139876
Filing Date: 2015-09-22
Classification: B01D,C07K,C08B,C12Q,G01N

Abstract:
1. A method of processing a low molecular weight heparin (LMWH) preparation, the method comprising: digesting the LMWH preparation with a heparinase I, a heparinase II, a heparinase III, a 2-O-sulfatase, and a Δ4,5 glycuronidase; providing a determination made using reverse phase high performance liquid chromatography (RP-HPLC), of whether all the structural moieties of the following first table: are present in the preparation in an amount which falls within Range A (mole %) of the following second table: and if said structural moieties are present in an amount that falls within Range A of the second table, then processing the LMWH preparation by a process selected from the group consisting of: classifying, selecting, accepting, releasing, shipping, formulating, labeling, and packaging, the LMWH preparation.