Patent ID: 6451798
Filing Date: 2002-09-17
Classification: C07D

Abstract:
A substituted piperazine compound having the following formula: whereinm=1 or 2; R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, halo, CF3, OR22 and straight or branched C1-4 alkyl that is optionally substituted with CF3 and wherein R22 is a straight or branched C1-3 alkyl; R6, R7 and R8 each independently selected from the group consisting of hydrogen and C1-3 alkyl; R9, R10, R11, R12, R13, R14, R15 and R16 are each independently selected from the group consisting of hydrogen, CON(R20)2, straight or branched C1-4 alkyl, or aryl wherein the alkyl and aryl substituents are each optionally substituted with 1 substituent selected from the group consisting of halo, CF3, OR20, N(R20)2, CON(R20)2 or aryl wherein R9 and R10 may together form a carbonyl, or R11 and R12 may together form a carbonyl, or R13 and R14 may together form a carbonyl, or R15 and R16 may together form a carbonyl; R17 is selected from the group consisting of straight or branched alkyl, cycloalkyl, and fused phenylcycloalkyl wherein the point of attachment is on the cycloalkyl wherein the alkyl, cycloalkyl, and fused phenylcycloalkyl are optionally substituted with from 1 and two substituents selected from the group consisting of halo, CF3, OR20, and aryl wherein the optionally aryl substituent is optionally substituted with from 1 to 3 substituents selected from the group consisting of halo, phenyl, CF3, CN, OR20, and straight or branched C1-6 alkyl; and R20 is selected from the group consisting of H, straight or branched C1-3 alkyl, or aryl, wherein the alkyl and aryl substituents are optionally substituted with 1 substituents individually selected from the group consisting of halo, â€”OMe, and CF3.