Patent ID: 6372735
Filing Date: 2002-04-16
Classification: A61P,C07C,C07D,C07F

Abstract:
A compound represented by formula (I) or a physiologically acceptable salt or solvate thereof: whereinR1 represents a hydrogen atom, a hydroxyl group, C1-4 alkyl, or phenyl C1-4 alkyl; R2, R3, R4, and R5, which may be the same or different, represent any one of the following (a) to (n): (a) a hydrogen atom; (b) a halogen atom; (c) an optionally protected hydroxyl group; (d) formyl; (e) C1-12 alkyl which may be substituted by a halogen atom; (f) C2-12 alkenyl which has one or more carbonâ€”carbon double bonds and may be substituted by (1) a halogen atom, (2) cyano, (3) â€”COR9 wherein R9 represents a hydrogen atom or C1-6 alkyl, (4) â€”COOR10 wherein R10 represents a hydrogen atom or C1-6 alkyl, (5) â€”CONR11R12 wherein R11 and R12, which may be the same or different, represent (i) a hydrogen atom, (ii) C1-6 alkyl which may be substituted by amino optionally substituted by C1-4 alkyl, phenyl optionally substituted by C1-4 alkyl which may be substituted by a saturated five- to seven-membered heterocyclic ring containing one or two nitrogen atoms (the nitrogen atoms may be substituted by C1-4 alkyl), or a saturated or unsaturated five- to seven-membered heterocyclic ring, (iii) phenyl which may be substituted by carboxyl, or (iv) a saturated or unsaturated five to seven-membered heterocyclic ring, (6) a saturated or unsaturated five- to seven-membered heterocyclic ring which may be substituted by C1-4 alkyl or may form a bicyclic ring fused with another ring; (g) C1-2 alkoxy which may be substituted by (1) a halogen atom, (2) a hydroxyl group, (3) cyano, (4) C3-7 cycloalkyl, (5) phenyl, (6) C1-4 alkoxy, (7) phenoxy, (8) amino which may be substituted by C1-4 alkyl, (9) â€”COR13 wherein R13 represents a hydrogen atom, C1-6 alkyl, phenyl optionally substituted by halogen or C1-4 alkoxy, or phenyl C1-4 alkyl, (10) â€”COOR14 wherein R14 represents a hydrogen atom or C1-6 alkyl, (11) â€”CONR15R16 wherein R15 and R16, which may be the same or different, represent a hydrogen atom or C1-6 alkyl which may be substituted by a saturated or unsaturated five- to seven-membered heterocyclic ring, or (12) a saturated or unsaturated five- to seven-membered heterocyclic ring which may be substituted by C1-4 alkyl or phenyl C1-4 alkyl; (h) â€”C&boxH;Nâ€”OR16a wherein R16a represents a hydrogen atom, C1-6 alkyl, phenyl C1-4 alkyl, or phenyl; (i) â€”(CH2)mOR17 wherein m is an integer of 0 to 4, and R17 represents a hydrogen atom, C1-6 alkyl, or phenyl C1-4 alkyl of which one or more hydrogen atoms on the benzene ring may be substituted by C1-4 alkyl; (j) â€”(CH2)kâ€”COR18 wherein k is an integer of 1 to 4, and R18 represents a hydrogen atom or C1-4 alkyl; (k) â€”(CH2)jâ€”COOR19 wherein j is an integer of 0 to 4, and R19 represents a hydrogen atom or C1-6 alkyl; (l) â€”(CH2)p-NR20R21 wherein p is an integer of 1 to 4, and R20 and R21, which may be the same or different, represent (1) a hydrogen atom, (2) C1-6 alkyl which may be substituted by amino optionally substituted by C1-4 alkyl, (3) phenyl C1-4 alkyl, (4) â€”COR22 wherein R22 represents a hydrogen atom or C1-4 alkyl which may be substituted by carboxyl, or (5) â€”SO2R23 wherein R23 represents C1-4 alkyl or phenyl which may be substituted by a halogen atom; (m) â€”(CH2)qâ€”CONR24R25 wherein q is an integer of 0 to 4, and R24 and R25, which may be the same or different, represent a hydrogen atom, a saturated or unsaturated five- to seven-membered heterocyclic ring, or C1-6 alkyl which may be substituted by a saturated or unsaturated five- to seven-membered heterocyclic ring, or alternatively R24 and R25 may form a saturated or unsaturated five- to seven-membered heterocyclic ring together with a nitrogen atom to which they are attached (the heterocyclic ring may further contain at least one oxygen, nitrogen, or sulfur atom, may form a bicyclic ring fused with another ring, or may be substituted by C1-4 alkyl); and (n) â€”NR26R27 wherein R26 and R27, which may be the same or different, represent a hydrogen atom or â€”COR28 wherein R28 represents a hydrogen atom, C1-6 alkyl, or phenyl which may be substituted by C1-4 alkyl or C1-6 alkoxy optionally substituted by phenyl; R31 and R32, which may be the same or different, represent a hydrogen atom or C1-6 alkyl which may be substituted by a halogen atom; and Q represents a group selected from the following groups (i) to (iv) or a halogen atom or C1-6 alkoxy: â€ƒwherein R33 represents C1-6 alkyl which may be substituted by C1-6 alkoxy optionally substituted by C1-6 alkoxy, phenyl optionally substituted by C1-6 alkoxy, amino, or nitro, or a saturated or unsaturated five- to seven-membered heterocyclic ring optionally substituted by C1-6 alkoxy, amino, or nitro, phenyl which may be substituted by C1-6 alkoxy, amino, or nitro, or a saturated or unsaturated five- to seven-membered heterocyclic ring which may be substituted by C1-6 alkoxy, amino, or nitro, or R33 may form C1-4 alkylene together with R31 or R32, R34 represents C1-16 alkyl which may be substituted by a halogen atom, carboxyl, phenyl optionally substituted by C1-6 alkoxy, amino, or nitro, or a saturated or unsaturated five- to seven-membered heterocyclic ring optionally substituted by C1-6 alkoxy, amino, or nitro, phenyl which may be substituted by C1-6 alkoxy, amino, or nitro, or a saturated or unsaturated five- to seven-membered heterocyclic ring which may be substituted by C1-6 alkoxy, amino, or nitro, R35 and R36, which may be the same or different, represent a hydrogen atom or C1-6 alkyl which may be substituted by amino optionally substituted by C1-4 alkyl or R35 and R36 may form a saturated or unsaturated five- to seven-membered heterocyclic ring together with a nitrogen atom to which they are attached, and R37 and R38, which may be the same or different, represent C1-6 alkyl, provided that the group â€”CR31R32Q does not represent C1-6 alkyl substituted by a halogen atom or C1-6 alkoxy.