Patent ID: 6610700
Filing Date: 2003-08-26
Classification: A61P,C07C,C07D

Abstract:
A compound according to formula (1): whereinR1 is a group Ar1L2Ar2Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an optionally substituted arylene or heteroarylene group and Alk is a chain â€”CH2â€”CH(R)â€”, â€”CH&boxH;C(R)â€”, in which R is a carboxylic acid (â€”CO2H) group;R2 is a hydrogen atom or a C1-6alkyl group; the ring Cy is an unsaturated cycloaliphatic or heterocycloaliphatic ring containing X, in which X is a N atom or a C(RW) group; RW is a group RZ; RX which maybe present or any available carbon atom of the ring Cy is a oxo (&boxH;O), thioxo (&boxH;S) or imino (&boxH;NR30) group in which R30 is an aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or hetero-aromatic group; m is zero or the integer 1, 2 or 3; RZ which may be present on any available carbon or nitrogen atom of the ring Cy is selected from a halogen atom or -(Alk4)VL1(Alk1)nR3 in which Alk4 is a straight or branched C1-3alkylene chain, v is zero or the integer 1, L1 is a covalent bond or a linker atom or group, n is zero or the integer 1, Alk1 is an optionally substituted aliphatic chain and R3 is a hydrogen atom or a â€”CN, â€”NO2 or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or hetero-aromatic group; p is zero or the integer 1, 2, 3 or 4; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof.