Patent ID: 8435544
Filing Date: 2013-05-07
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition in the form of mixed micelles, comprising: a calcineurin inhibitor or a mammalian target of rapamycin (mTOR) inhibitor; vitamin E tocopherol polyethylene glycol succinate (TPGS) with a hydrophilic/lipophilic balance (HLB) index greater than about 10; and octoxynol-40 with an HLB index of greater than about 13, wherein an absolute difference between the HLB index of the vitamin E TPGS and the HLB index of the octoxynol-40 is greater than about 3, and wherein the composition is in the form of mixed micelles having the vitamin E TPGS and the octoxynol-40.