Patent ID: 8784823
Filing Date: 2014-07-22
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating a human condition, disorder or disease mediated in whole or in part by CD40 signaling, or a symptom of any of the foregoing, the method comprising the step of administering to a subject in need thereof a therapeutically effective amount of a CD154 binding protein comprising heavy chain CDR1, CDR2 and CDR3 sequences selected from: (a) SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; (b) SEQ ID NO: 42, SEQ ID NO: 43 and SEQ ID NO: 44, respectively; or (c) SEQ ID NO: 48, SEQ ID NO: 49 and SEQ ID NO: 50, respectively; and comprising light chain CDR1, CDR2 and CDR3 sequences selected from: (a) SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8, respectively; (b) SEQ ID NO: 45, SEQ ID NO: 46 and SEQ ID NO: 47, respectively; or (c) SEQ ID NO: 51, SEQ ID NO: 52 and SEQ ID NO: 53, respectively, wherein the condition, disorder or disease is an inflammatory or autoimmune response or fibrosis.