Patent ID: 9045564
Filing Date: 2015-06-02
Classification: C07K

Abstract:
1. A polypeptide comprising a human serum albumin (HSA) portion, which HSA portion comprises HSA domain III, or neonatal Fc receptor (FcRn) binding fragment thereof wherein the HSA domain III, or a neonatal Fc receptor (FcRn) binding fragment thereof, comprises amino acid substitutions at positions, numbered relative to the position in full length mature HSA, selected from the group consisting of: (a) residues 463 and 508; (b) residues 463 and 523; (c) residues 463 and 524; (d) residues 508 and 523; (e) residues 508 and 524; (f) residues 523 and 524; (g) residues 463, 508 and 523; (h) residues 463, 508 and 524; (i) residues 463, 523 and 524; (j) residue 508, 523 and 524; and (k) residue 463, 508, 523 and 524, wherein the substitutions increase one or both of affinity for FcRn and serum half-life of the polypeptide relative to a control polypeptide in which the HSA portion does not include said amino acid substitutions.