Patent ID: 6172256
Filing Date: 2001-01-09
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for the preparation of a chiral .beta.-amino ester of the formula ##STR111##wherein R is lower alkyl; X and Y are the same or different halogens selected from the group consisting of Cl, Br and I; comprising protecting the amino group of a racemic amino acid of the formula ##STR112##with a CBZ protecting group to produce a protected amino acid compound of the formula ##STR113##subjecting the protected amino acid compound so obtained to chiral chromatography to obtain a chiral protected amino acid of the formula ##STR114##deprotecting the chiral protected amino acid so obtained by reacting with trimethylsilyl iodide in dichloromethane; and isolating the chiral .beta.-amino ester of the formula ##STR115##