Patent ID: 6624189
Filing Date: 2003-09-23
Classification: A61P,C07D

Abstract:
A compound having the structure represented by Formula I: wherein: R20 is H, OH, or O2CRâ€²; R21 is &boxH;CRaRb or R21 represents independent moieties Rc and Rd where: Ra and Rb are independently H, CO2Râ€² or Râ€²; Rc and Rd are independently H, alkyl, alkenyl or alkynyl containing 1 to 20 carbon atoms, or (CH2)n CO2Râ€² where n is 1, 2 or 3; R26 is H, OH or Râ€²; each Râ€² being independently selected from the group: alkyl, alkenyl or alkynyl containing 1 to 20 carbon atoms, or aryl, heteroaryl, aralkyl or heteroaralkyl containing 2 to 20 carbon atoms; and L consists essentially of a straight or branched linear, cyclic or polycyclic, lipophilic moiety containing a continuous chain of from 6 to 14 chain atoms, which substantially maintains relative distance of the C1 and C17 atoms and the directionality of the C1C2 and C16C17 bonds of naturally-ocurring bryostatin; and Z is â€”Oâ€” or â€”N(H)â€”; or a pharmaceutically acceptable salt thereof, excluding the compounds of Formula I where R26 is methyl.