Patent ID: 6544546
Filing Date: 2003-04-08
Classification: A61K,Y10S

Abstract:
A ring-shaped device comprising:(a) a first compartment comprising a non-medicated core of ethylene-vinylacetate copolymer, encircled by steroid hormone loaded ethylene-vinylacetate copolymer middle layer, and a non-medicated outer layer of ethylene-vinylacetate copolymer; (b) a second compartment comprising a core of ethylene-vinylacetate copolymer loaded with a steroid hormone and a non-medicated outer layer of ethylene-vinylacetate copolymer; and wherein the ethylene-vinylacetate copolymer middle layer of the first compartment is saturated with the steroid hormone and comprises steroid hormone is crystalline form, said first compartment having been manufactured by co-extruding the core, the middle layer and the outer layer, wherein during co-extrusion the middle layer is saturated with steroid hormone and comprises steroid hormone in crystalline form, and wherein said ring-shaped device possesses an unexpectedly uniform steroid hormone release.