Patent ID: 6596924
Filing Date: 2003-07-22
Classification: A01K,A61K

Abstract:
A graft mouse model for improving the rate of induction and formation of human papillomas comprising:(a) a recipient mouse selected from the group consisting of: severe combined immuno-deficient (SCID) mice, SCID/beige mice, nude mice, and NIH-nu-bg-xid mice, said mouse being grafted with human foreskin tissue, said foreskin tissue having been meshed prior to said grafting; and (b) inoculating said grafted foreskin tissue prior to healing with an inoculum of human papillomavirus, wherein said grafted foreskin is supported by said recipient mouse and is capable of inducing and sustaining growth of said human papillomavirus and harboring at least one papilloma containing infectious viral particles.