Patent ID: 8999654
Filing Date: 2015-04-07
Classification: A01K,A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method for identifying a candidate compound for use in reducing the body weight of a mammalian subject, said method comprising: (a) contacting a cell expressing a SREB3 polypeptide comprising an amino acid sequence having at least 95% identity to the amino acid sequence set forth in SEQ ID NO. 243 with a candidate compound; (b) measuring the expression of said SREB3 polypeptide expressed in said cell, (c) contacting a cell expressing a SREB2 polypeptide comprising an amino acid sequence having at least 95% identity the amino acid sequence set forth in SEQ ID NO. 552 with said candidate compound; and (d) measuring the expression of said SREB2 polypeptide expressed in said cell, wherein the candidate compound is identified as a compound for use in reducing the body weight of a mammalian subject when a decrease in the expression of said SREB3 polypeptide is measured in a cell contacted with said compound relative to a cell not contacted with said compound and a decrease in the expression of said SREB2 polypeptide is measured in a cell contacted with said compound, relative to a cell not contacted with said candidate compound.