Patent ID: 6204249
Filing Date: 2001-03-20
Classification: A61P,C07H

Abstract:
A compound of the formula (I): ##STR9##whereinR.sup.1 represents hydrogen, a halo atom, azido,--NR.sup.8 R.sup.9 where R.sup.1 and R.sup.9 are the same or different and are each independently selected from the group consisting of hydrogen, hydroxyl, C.sub.1-12 alkyl, where the alkyl moiety is optionally substituted by one or more substituents selected from the group consisting of halo, amino, azido, hydroxy, cyano, NO.sub.2, NHR.sup.10, SO.sub.2 R.sup.10, SR.sup.10, OR.sup.10, COR.sup.10 and haloC.sub.1-6 alkyl where R.sup.10 is C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.2-6 alkynyl, or aryl, C.sub.2-8 alkenyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl, C.sub.2-8 alkynyl, C.sub.3-7 cycloalkenyl, C.sub.3-7 cycloalkylC.sub.1-6 alkyl, aryl, arylC.sub.1-6 alkyl, heteroaryl, heterocarylC.sub.1-6 alkyl, heterocyclyl and heterocyclylC.sub.1-6 alkyl or R.sup.8 R.sup.9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring;--NHNR.sup.11 R.sup.12 where R.sup.11 and R.sup.12 are the same or different and each represent hydrogen or C.sub.1-6 alkyl;--N.dbd.NC.sub.1-6 alkyl or --NHOC.sub.1-6 alkyl;R.sup.2 represents hydrogen, halo atom, C.sub.1-6 alkyl or C.sub.2-6 alkenyl;R.sup.3 and R.sup.4 are the same or different and each represent hydrogen, halogen or NO.sub.2 ;wherein the sugar moiety of Formula I ##STR10##is selected from the group consisting of: ##STR11##with the proviso that when R.sup.2 represents hydrogen, R.sup.3 and R.sup.4 each represent chloro, and the sugar moiety is ##STR12##then R.sup.1 represents:azido,--NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are the same or different and are each independently selected from the group consisting of hydroxyl, C.sub.1-6 alkyl, where the alkyl moiety is substituted by one or more substituents selected from the group consisting of amino, azido, NO.sub.2, NHR.sup.10, SO.sub.2 R.sup.10, SR.sup.10, OR.sup.10, haloC.sub.1-6 alkyl where R.sup.10 is as hereinbefore defined, C.sub.7-12 alkyl (where the alkyl moiety is optionally substituted by one or more substituents selected from the group consisting of halo, amino, azido, hydroxy, cyano, NO.sub.2, NHR.sup.10, SO.sub.2 R.sup.10, SR.sup.10, OR.sup.10, COR.sup.10 and haloC.sub.1-6 alkyl where R.sup.10 is as hereinbefore defined), C.sub.1-6 alkoxy, C.sub.3-7 cycloalkenyl, heteroaryl, heteroaryl C.sub.1-6 alkyl and heterocyclyl;--NHR.sup.11 R.sup.12 where R.sup.11 and R.sup.12 are as hereinbefore defined;--N.dbd.NC.sub.1-6 alkyl or--NHOC.sub.1-6 alkyl;or a pharmaceutically acceptable derivative thereof.