Patent ID: 7122666
Filing Date: 2006-10-17
Classification: C07D

Abstract:
1. A compound of formula (I)′, or a pharmacologically acceptable salt, ester or amide thereof: wherein: A′ represents a pyrrole ring; R R R  wherein m′ represents 1, E′ represents a nitrogen atom and D′ represents a group of formula >C(R B′ represents a 5-membered heterocyclic ring which has one ring nitrogen atom, said heterocyclic ring being saturated or unsaturated, and is unfused or fused with a group selected from the group consisting of aryl groups defined below, heteroaryl groups defined below, cycloalkyl groups defined below and heterocyclyl groups defined below, and R when B′ is a heterocyclic ring which is fused to an aryl group, a heteroaryl group, a cycloalkyl group or a heterocyclyl group, R provided that said substituents R Substituent group α′ is selected from the group consisting of hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, halogeno lower alkylthio groups defined below and groups of formula —NR Substituent group β′ is selected from the group consisting of lower alkyl groups defined below which are unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α defined above, lower alkenyl groups defined below which are unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α′ defined above, lower alkynyl groups defined below which are unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α′ defined above, aralkyl groups defined below and cycloalkyl groups defined below; Substituents group γ′ is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups defined below, lower alkylene groups defined below, lower alkylenedioxy groups defined below, lower alkylsulfinyl groups defined below, lower alkylsulfonyl groups defined below, aryl groups defined below which are unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α′ defined above and Substituent group β′ defined above, aryloxy groups defined below which are unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α′ defined above, Substituent group β′ defined above, lower alkylidenyl groups and aralkylidenyl groups; said aryl groups in the definitions of ring B′ and Substituent group γ′ above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aryl groups being unfused or fused with a cycloalkyl group having from 3 to 10 carbon atoms; said heteroaryl groups in the definition of ring B′ above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heteroaryl groups being unfused or fused with another cyclic group selected from the group consisting of aryl groups defined above and cycloalkyl groups having from 3 to 10 carbon atoms; said lower alkyl groups in the definitions of R said lower alkenyl groups in the definitions of R said lower alkynyl groups in the definitions of R said aralkyl groups in the definitions of R said lower alkylsulfonyl groups in the definitions of R where ring B′ is fused with a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain from 1 to 3 ring heteroatoms selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms; where R said lower alkoxy groups in the definition of Substituent group α′ above are groups in which an oxygen atom is bonded to a lower alkyl group as defined above; said halogeno lower alkoxy groups in the definition of Substituent group α′ above are groups in which a lower alkoxy group as defined above is substituted with at least one halogen atom; said lower alkylthio groups in the definition of Substituent group α′ above are groups in which a sulfur atom is bonded to a lower alkyl group as defined above; said halogeno lower alkylthio groups in the definition of Substituent group α′ above are groups in which a lower alkylthio group as defined above is substituted with at least one halogen atom; said cycloalkyl groups in the definitions of Substituent group β′ and ring B′ are cycloalkyl groups having from 3 to 7 carbon atoms; said lower alkoxyimino groups in the definition of Substituent group γ′ above are groups wherein the hydrogen atom of a hydroxyimino group is replaced by a lower alkyl group as defined above; said lower alkylene groups in the definition of Substituent group γ′ above are alkylene groups having from 2 to 6 carbon atoms; said lower alkylenedioxy groups in the definition of Substituent group γ′ above are groups wherein an alkylene moiety, which is a straight or branched chain alkylene group having from 1 to 6 carbon atoms, is subsitituted with 2 oxy groups; said lower alkylsulfinyl groups in the definition of Substituent group γ′ above are groups in which a lower alkyl group as defined above is bonded to a sulfinyl group; said lower alkylidenyl groups in the definition of Substituent group γ′ above are straight or branched alkylidenyl groups having from 1 to 6 carbon atoms; said aralkylidenyl groups in the definition of Substituent group γ′ above are lower alkylidenyl groups as defined above which are substituted with 1 or more aryl groups as defined above; said unsubstituted or substituted aryloxy groups in the definition of Substituent group γ′ above are groups in which an oxygen atom is attached to an aryl group as defined above.