Patent ID: 6201158
Filing Date: 2001-03-13
Classification: C07C

Abstract:
A method of synthesizing a compound of formula (I): ##STR14##wherein R.sup.1 represents aryl, alkyl, alkynyl, alkylsilyl, ester or ether; said aryl, alkyl and alkynyl being optionally substituted with one to three groups selected from R.sup.a, R.sup.2 is aryl or C.sub.1-6 alkyl; said aryl and C.sub.1-6 alkyl being optionally substituted with one to three groups selected from R.sup.a, comprising:reacting a compound of formula (II): ##STR15##wherein R.sup.1 is defined above;with a compound of formula (III):R Zn R (III)wherein, R is C.sub.1-6 alkyl or aryl;in the presence of a chiral ligand of formula (IV): ##STR16##wherein, R.sup.3 and R.sup.4 are independently aryl, alkylaryl, alkyl, or H; said aryl, akylaryl and alkyl being optionally substituted with one to three groups of R.sup.a, or R.sup.3 and R.sup.4 together can form a 5- or 6-membered ring, which can be optionally substituted with one to three groups of R.sup.a ;R.sup.5 and R.sup.6 are independently, H, alkyl, aryl, said alkyl and aryl being optionally substituted with one to three groups of R.sup.a, or R.sup.5 and R.sup.6 together with the N atom to which they are attached form a 5- or 6-membered heterocyclic ring, which can be optionally substituted with one to three groups of R.sup.a and;R.sup.a is H, C.sub.1-10 alkyl, halogen, NO.sub.2, OR, --NR, C.sub.5-10 aryl or C.sub.5-10 heteroaryl;adding the resultant mixture to a compound of formula (V): ##STR17##wherein, R.sup.2 is defined above to produce a compound of formula (I).