Patent ID: 9005655
Filing Date: 2015-04-14
Classification: A61K,A61P

Abstract:
1. A long circulating non-pegylated liposomal doxorubicin composition for parenteral administration consisting of, doxorubicin hydrochloride non-pegylated liposomes, histidine hydrochloride, sucrose, ammonium sulfate and water; wherein the doxorubicin non-pegylated liposomes consist of doxorubicin hydrochloride, cholesterol, sucrose, water and saturated phosphatidylcholines wherein the saturated phosphatidylcholines consist of distearoylphosphatidyl choline (DSPC) and/or hydrogenated soya phosphatidylcholines (HSPC); wherein the doxorubicin hydrochloride is encapsulated in liposomes having an average size 0.06 μm to 0.16 μm; and wherein the non-pegylated doxorubicin liposomes have a circulation time in blood at least 25 times longer than that of ADRIAMYCIN when tested in Swiss albino mice at equivalent doses.