Patent ID: 6221670
Filing Date: 2001-04-24
Classification: A61P,G01N

Abstract:
A method for identifying a beta amyloid reducing agent which method comprises(a) contacting a test compound with a test organotypic brain slice culture and measuring (1) the viability and (2) the amount of beta amyloid production of said test organotypic brain slice culture; and,(b) measuring (1) the viability and (2) the amount of beta amyloid production of a control organotypic brain slice culture; and(c) identifying as a beta amyloid reducing agent a test compound which reduces the amount of beta amyloid production in said test culture as compared to said control culture, but does not reduce viability of said test culture in comparison with said control culture;wherein said test organotypic brain slice culture and control brain slice culture contain viable cells and are derived from a mammal.