Patent ID: 9005619
Filing Date: 2015-04-14
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating cancer, the method comprising: administering to a patient a composition comprising an agonistic antibody to a molecule; whose expression increases on surfaces of natural killer (NK) cells that mediate antibody-dependent cellular cytotoxicity (ADCC) when such cells are exposed to tumor cells bound by an anti-tumor antibody (an “inducible costimulatory molecule”), which agonistic antibody is characterized as agonistic in that, when the NK cells with the inducible costimulatory molecule on their surface are contacted with the agonistic antibody, their ADCC is increased as compared with that observed absent such contact; the patient having received anti-tumor antibody therapy a period of time prior to the administering, such that the increase in expression of the inducible costimulatory molecule has occurred.