Patent ID: 9090695
Filing Date: 2015-07-28
Classification: A61P,C07K

Abstract:
1. An isolated antibody or antigen-binding portion thereof that selectively binds to an epitope located in an extracellular domain of natriuretic peptide receptor A (NPRA) wherein said epitope forms when said NPRA is bound to atrial natriuretic peptide (ANP), or brain natriuretic peptide (BNP), wherein said antibody or antigen-binding portion thereof is not reactive with the atrial natriuretic peptide (ANP), or brain natriuretic peptide (BNP) binding site of NPRA, wherein said epitope is located in the three dimensional structure of NPRA when NPRA is bound to ANP or BNP, wherein said epitope comprises amino acids within NLTVAVVLPLANTSYPWSWARV (SEQ ID NO:30), VKDEYALTT (SEQ ID NO:31), TMEDGLVN (SEQ ID NO:32), HDGLLLY (SEQ ID NO:33) and VTDGE (SEQ ID NO:34).