Patent ID: 6620600
Filing Date: 2003-09-16
Classification: C07C,C12P,H01M,Y02E

Abstract:
A method of resolving a racemic mixture of a compound of formula I wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1, to C6 alkyl, trifluoromethyl or halo, R5 is halo or â€”Sâ€”R1 wherein R1 is H or acetyl, and R2 is C1 to C6 alkyl, to obtain a desired enantiomer of the corresponding acid wherein R2 is hydrogen comprising:a) reacting the ester compound of formula I with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and b) isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase and said solvent is selected to be effective to produce an enantiomeric excess of the desired enantiomer of the acid of at least 88% and preserve at least 90% of the enzymatic activity of the lipase.