Patent ID: 8932635
Filing Date: 2015-01-13
Classification: A61K,A61P

Abstract:
1. Microparticles for use in a pharmaceutical composition for pulmonary administration, comprising particles of an active substance having, on their surfaces, particles of a hydrophobic material comprising magnesium stearate suitable for promoting the dispersal of the active particles on actuation of an inhaler and suitable for delaying the dissolution of the active substance, the microparticles being such that the active substance exerts its pharmacological effect over a period of greater than 12 hours and the microparticles comprise a rapidly dissolving active substance under the conditions obtained in the lung, wherein the microparticles comprise an effective amount of at least one of the substances selected from the group consisting of an antimuscarinic substance, a β2-agonist, a steroid, a peptide and a polypeptide.