Patent ID: 6424921
Filing Date: 2002-07-23
Classification: C12Q,G16B

Abstract:
A computer-implemented method of averaging a plurality of hybridization data arrays, each hybridization data array having a plurality of array locations storing relative transcript abundance ratios, each relative transcript abundance ratio being the ratio of two hybridization measures and having a positive value greater than 0.0, to provide a single averaged hybridization data array having an averaged relative abundance value in each of the array locations, the method comprising:for each array location on each of the plurality of arrays, converting the relative transcript abundance ratio to a fractional percent difference value (FPD) having a value over a range of at least âˆ’1 to 1, to provide a plurality of FPD's; for each array location, determining an average FPD from the plurality of FPD's; for each array location, converting the average FPD to a differential expression (DE) having a value in the range [âˆ’âˆž, âˆ’1)âˆª[1, âˆž), the DE values representing the averaged relative transcript abundance ratios; and storing the plurality of DE values in an averaged hybridization data array.