Patent ID: 6171576
Filing Date: 2001-01-09
Classification: A61K,C07C,C07D

Abstract:
A radiopharmaceutical compound which is capable of complexing with .sup.99m Tc, said compound having the following structural formula: ##STR5##whereinR.sub.1 is selected from COOR.sup.a, COR.sup.a, CONHR.sup.a, CONR.sup.a R.sup.b, CH.sub.2 CH.sub.3, (CH.sub.2).sub.n CH.sub.3, CHCHR.sup.c, (CH.sub.2).sub.n CCR.sup.c or an ester bioisostere;R.sub.2 is selected from C.sub.6 H.sub.4 X, C.sub.6 H.sub.3 X.sub.2, C.sub.10 H.sub.6 X, or C.sub.12 H.sub.8 WYCHO (diarylmethoxy);R.sup.a and R.sup.b are each selected from CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3, (CH.sub.2).sub.n CH.sub.3, CH(CH.sub.3).sub.2, C(CH.sub.3).sub.3, (CH.sub.2).sub.n C.sub.6 H.sub.5, C.sub.6 H.sub.5, C.sub.6 H.sub.4 X, C.sub.10 H.sub.7, or C.sub.10 H.sub.6 X;R.sup.c is selected from COOR.sup.a, CH.sub.3, (CH.sub.2).sub.n CH.sub.3, C.sub.6 H.sub.5, C.sub.6 H.sub.4 X, C.sub.10 H.sub.7, or C.sub.10 H.sub.6 X;X is selected from H, Br, Cl, I, F, OH, OCH.sub.3, CF.sub.3, NO.sub.2, NH.sub.2, CN, OR, NHCOCH.sub.3, N(CH.sub.3).sub.2, CH.sub.2 CH.sub.3, CHOCH.sub.3, C(CH.sub.3).sub.3 ;W and Y are each selected from H, Br, Cl, I, F, OH, OCH.sub.3, CF.sub.3, NO.sub.2, NH.sub.2, CN, OR, NHCOCH.sub.3, N(CH.sub.3).sub.2 ;n is an integer 0-6;L is a linking moiety comprising a chain of atoms containing 2 to about 6 carbon atoms in the backbone of the chain or, if a ring is part of the chain, 1 to about 4 carbon atoms in the backbone of the chain in addition to the ring carbons; andCh is a tridentate or tetradentate chelating ligand capable of forming a neutral complex with technetium or rhenium.