Patent ID: 9200279
Filing Date: 2015-12-01
Classification: A61K,A61P,C07H,C07K,C12N

Abstract:
1. A method of treating a disease which comprises administering a therapeutically effective amount of a molecule to an individual in need thereof, wherein the disease is one that can be treated by regulating the Stat3 pathway or genes under control of Stat3, wherein the molecule comprises a modified human STAT3 sense strand and a human CpG(D19)-STAT3 antisense strand, wherein the modified human STAT3 sense strand comprises an oligonucleotide having the nucleotides set forth in SEQ ID NO:17, wherein the modifications are selected from the group consisting of 2′F, 2′OMe, LNA, nucleotides and other modifications described herein, wherein the human CpG(D19)-STAT3 antisense strand comprises (a) a first oligonucleotide having the nucleotides set forth in SEQ ID NO:16, (b) a C3 carbon chain or propanediol linker and (c) a second oligonucleotide having the nucleotides set forth in SEQ ID NO:5 that is the antisense strand, and wherein the sense strand and the antisense strand anneal to form a double stranded siRNA.