Patent ID: 7589061
Filing Date: 2009-09-15
Classification: A61K,A61P

Abstract:
1. A somatostatin receptor (sst) binding molecule comprising: a peptidic ligand that binds the somatostatin receptor, the peptidic ligand selected from the group consisting of octreotide and octreotate; a carbohydrate, wherein the carbohydrate is a sugar selected from the group consisting of glucose, galactose, maltose, mannose, maltotriose, and lactose; a chelating group that complexes a radioisotope selected from Tc and Re, the chelating group selected from the group consisting of histidine, picolylamine diacetic acid, hydroxy nicotine amide (HYNIC) and mercaptoacetyl-glycyl-glycine (MAG3); and, a multifunctional linker unit selected from the group consisting of lysine, ornithine serine, glutamic acid, aspartic acid, O-amine serine, and mercaptopropionic acid, wherein the multifunctional linker unit is covalenty bound to the peptidic ligand and the chelating group, and further wherein the carbohydrate is covalently bound to the multifunctional linker unit or the chelating group.