Patent ID: 8569426
Filing Date: 2013-10-29
Classification: A61K,A61P,C07D

Abstract:
1. A process for the preparing a conjugate of the formula I: B is a bio-compatible polymer moiety optionally covalently attached to a branched-arm hub molecule; q is from about 1 to about 100; A at each occurrence is independently a compound of formula II or a pharmaceutically acceptable salt thereof, wherein J is a group of formula: Ar T is a group of formula R provided that: comprising the steps of: a) adding a polymeric alcohol of formula Ia  wherein B and q are as described above, to a nucleophile of formula H-Nu in the presence of a trivalent phosphine and a dialkyl azodicarboxylate to form the compound of formula I, wherein Nu is a radical of formula A described above; and b) isolating the compound of formula I.