Patent ID: 6057358
Filing Date: 2000-05-02
Classification: A61P,C07C,C07D

Abstract:
An amine derivative of the general formula (I) set forth below or a salt thereof: ##STR10## (wherein A denotes the general formula --(CH.sub.2).sub.m --, --(CH.sub.2).sub.m --O--, --(CH.sub.2).sub.m --NH-- or --(CH.sub.2).sub.m --SO.sub.2 --, where a hydrogen atom in the --(CH.sub.2).sub.m -- moiety may be substituted by one or more hydroxyl groups;B denotes a group of the general formula --(CH.sub.2).sub.n --, --NR.sub.7 --(CH.sub.2).sub.n -- or --CONH--(CH.sub.2).sub.n --;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 denote each independently a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group, a lower alkoxy group, a lower alkanoyl group, a nitro group, a hydroxyl group, a lower alkylsulfonyloxy group, a phenoxymethyl group, a heterocyclic group or the group of the general formula --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 denote each independently a hydrogen atom, a lower alkanoyl group, a lower alkyl group or a heterocyclic group;R.sub.9 denotes a hydrogen atom, a halogen atom, a nitro group, an amino group, a lower alkyl group, a lower alkanoylamino group or a lower alkylamino group;R.sub.8a and R.sub.8b denote the same halogen atom or lower alkoxy group or, alternatively, when R.sub.8a is a hydrogen atom, R.sub.8b denotes a lower alkylsulfonylamino group or a halogen atom (provided that when R.sub.8a is a hydrogen atom and R.sub.8b is a lower alkylsulfonylamino group, R.sub.1 denotes a group of the general formula --NR.sub.5 R.sub.6) or a heterocyclic group);R denotes a lower alkyl group or an aryl group;R.sub.7 denotes a hydrogen atom or a lower alkyl group;X denotes a group of the general formula --NR.sub.10 R.sub.11, a nitro group, a cyano group or a heterocyclic group, where R.sub.10 and R.sub.11 denote each independently a hydrogen atom or a lower alkylsulfonyl group;m and n denote an integer of 0-3.