Patent ID: 6329383
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A compound of the formula (I) ##STR62##wherein Y--X is >C.dbd.X and X is NR8, O, or S and R2 is H, C.sub.1 -C.sub.8 alkyl, substituted C.sub.1 -C.sub.8 alkyl(Ring) or substituted Ring; orY--X is >C--X and X is H, C.sub.1 -C.sub.8 alkyl, substituted C.sub.1 -C.sub.8 alkyl, Ring, substituted Ring, OR9 or NHR9 and R2 is a bond to Y;Z is O, S or NR12;R1 is H, methyl, propyl, butyl, substituted C.sub.1 -C.sub.8 alkyl, Ring or substituted Ring;R3 is H, C.sub.1 -C.sub.8 alkyl, substituted C.sub.1 -C.sub.8 alkyl, Ring, substituted Ring, OR9 or NHR9;R4, R5, R6 and R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination, and/or two adjacent R4, R5, R6 or R7 form Ring; andR8, R9, R10, R11, R12 and R13 are H, C.sub.1 -C.sub.8 alkyl, substituted C.sub.1 -C.sub.8 alkyl(Ring), Ring and/or substituted Ring in any combination; andwherein Ring is a C.sub.5 -C.sub.12 ring, optionally including one or two ring heteroatoms selected from the group consisting of O, S and N, and the substituents for the substituted groups are individually selected from the group consisting of halogen, OH, C.sub.1 -C.sub.8 alkyl, OR10, NR10, R11, NO2, CF3, CN, COR8 and COOR8.