Patent ID: 6476011
Filing Date: 2002-11-05
Classification: A61K,C07D,C07J

Abstract:
A method for introducing an estrogenic compound into a subject in need thereof comprising administering an effective amount of a ring system compound having the formula (II) wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl; and at least one of R1 and R2 is II, or together represent alkylene optionally having one or more hetero atoms or groups in the alkylene chain; and the ring system ABCD represents a substituted or unsubstituted, saturated or unsaturated steroid nucleus selected from the group consisting of oestrones, dehydroepiandrosterones, substituted oestrones, oestradiols, substituted oestradiols, oestriols, substituted dehydroepiandrosterones and substituted oestriols; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2), or a pharmaceutically acceptable salt thereof.