Patent ID: 8906859
Filing Date: 2014-12-09
Classification: A61K,A61P,C07K

Abstract:
1. A method of prophylaxis or treatment of a kappa opioid receptor-associated disease or condition in a mammal, wherein the kappa opioid receptor-associated disease or condition is an inflammatory disease or condition associated with an elevated level of a pro-inflammatory cytokine, the method comprising administering to the mammal a composition comprising an effective amount of a synthetic peptide amide of the formula; or a stereoisomer, mixture of stereoisomers, pharmaceutically acceptable salt, hydrate, acid salt hydrate, or N-oxide thereof, wherein Xaa Xaa Xaa Xaa G is wherein W is selected from the group consisting of; wherein V is C wherein provided that when the Y and Z-containing ring moiety is a six or seven membered ring comprising a single ring heteroatom and wherein such heteroatom is N, and e is zero, then R provided further that when the Y and Z-containing ring moiety is a six membered ring comprising two ring heteroatoms, both Y and Z are N, W is null, and —V lastly, provided that if the Y and Z-containing ring moiety is a six membered ring comprising an S or O ring heteroatom, or if the Y and Z-containing ring moiety is a six membered ring comprising two ring heteroatoms, wherein both Y and Z are N and W is null, or if the Y and Z-containing ring moiety is a six membered aromatic ring comprising a single ring heteroatom, which heteroatom is N, then, when e is zero, R