Patent ID: 6727098
Filing Date: 2004-04-27
Classification: C07B,C07C,C07D,Y10T

Abstract:
A method for determining an absolute configuration of a chiral compound, which comprises steps of:(a) selecting a chiral compound from the group consisting of alcohols, thiols and amines; (b) introducing an achiral circular dichroism (CD) chromophore represented by formula I: (wherein R is H, Meâ€”, Etâ€”, i-Prâ€”, n-Buâ€”, i-Buâ€” or t-Buâ€” and X is H, Meâ€”, Me2Nâ€”, MeOâ€”, NO2â€”, NH2â€”, CNâ€”, Cl or Br, and Y is OHâ€”, CNâ€”, provided that X is Me2Nâ€” or CNâ€” when R&boxH;H and Y&boxH;OH, X is Meâ€”, Me2Nâ€”, NO2â€”, NH2â€” or CNâ€” when R&boxH;Me and Y&boxH;OH, and X is Meâ€”, Me2Nâ€”, MeOâ€”, NO2â€”, NH2â€” or CNâ€” when R&boxH;Et and Y&boxH;OH, and R is t-Buâ€” when X&boxH;H and Y&boxH;OH) into the chiral compound; and(c) determining the absolute configuration of the chiral compound from relative bulkiness of a substituent on &agr;-carbon, preferential order in a sequence rule (CIP method) and sign of exciton chirality.