Patent ID: 8187818
Filing Date: 2012-05-29
Classification: C12Q,G01N

Abstract:
1. A method for determining an increased risk of mortality or risk of a cardiac and/or vascular event in a patient, wherein said cardiac and/or vascular event is selected from the group consisting of myocardial infarction, vascular cerebral accident, hospitalization due to cardiac and/or vascular disease, and revascularization procedure, the method comprising: determining a value of secretory phospholipase A2 (sPLA2) activity of said patient as a first risk marker, wherein the sPLA2 activity is measured from a blood sample of said patient, and locating this value in an interval of a set of predetermined intervals of sPLA2 activity range obtained from a given population, wherein said predetermined intervals are medians, tertiles, quartiles or quintiles of sPLA2 activity range of said given population, determining a value of C-reactive protein (CRP) level of said patient as a second risk marker, wherein the CRP level is measured from a blood sample of said patient, and locating this value in an interval of a set of predetermined intervals of CRP level obtained from said given population, wherein said predetermined intervals are medians, tertiles, quartiles or quintiles of CRP level range of said given population and, assessing a combined interval obtained by combining the two above mentioned intervals of said patient, said combined interval being indicative of an increased risk of mortality or risk of a cardiac and/or vascular event in the patient.