Patent ID: 6313109
Filing Date: 2001-11-06
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound of formula V ##STR17##whereinAr is optionally substituted aryl or optionally substituted heterocycle, wherein each substituent is independently selected from the group consisting of aryl, heterocycle, halogen, OR.sup.9, NR.sup.9 R.sup.10, CN, NO.sub.2, CF.sub.3, and lower alkyl, said lower alkyl optionally substituted with (C.sub.1 -C.sub.4)-alkoxy, NR.sup.9 R.sup.10, (C.sub.3 -C.sub.6)-cycloalkyl, or OH;R.sup.1 and R.sup.2 each is, independently, CH.sub.2 or C(O);R.sup.3 and R.sup.4 each is, independently, H or CH.sub.3 ;R.sup.5, R.sup.6, R.sup.7, and R.sup.8 each is independently selected from the group consisting of H, or an optionally substituted moiety selected from the group consisting of (C.sub.1 -C.sub.8)-alkyl, alkenyl, alkynyl, aryl, and heterocycle;wherein said optionally substituted moiety is optionally substituted by one or more substituents independently selected from the group consisting of (C.sub.3 -C.sub.6)-cycloalkyl, optionally further substituted aryl, and optionally further substituted heterocycle,wherein said optionally further substituted aryl and heterocycle are optionally substituted by one or more substituents independently selected from the group consisting of (C.sub.1 -C.sub.4)-alkyl, halogen, (CH.sub.2).sub.m OR.sup.9, and (CH.sub.2).sub.m NR.sup.9 R.sup.10 ;R.sup.9 and R.sup.10 each is, independently, H lower alkyl or (C.sub.3 -C.sub.6)-cycloalkyl;R.sup.11 is H or NH.sub.2 ;m is 0 or an integer from 1 to 4; andn is 0, 1, or 2;or a pharmaceutically acceptable salt thereof.