Patent ID: 7141673
Filing Date: 2006-11-28
Classification: C07D

Abstract:
1. A process for preparing 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulfonyl)phenyl]ethanone of formula: comprising initially reacting 2-methyl-5-vinylpyridine with ozone and subsequently reducing the ozonized 2-methyl-5-vinylpyridine that is thereby converted into 2-methylpyridine-5-carbaldehyde that is used without isolation, and reacting it with a dialkylamine and a cyano compound to give an N,N dialkylamino-(6-methyl-3-pyridyl)-acetonitrile of formula: wherein R 1 and R 2 are identical or different and are C 1-4 -alkyl, and, finally, in the presence of a base, reacting said acetonitrile of formula III with a 4-(methylsulfonyl)benzyl halide to give 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone of formula I.