Patent ID: 6156884
Filing Date: 2000-12-05
Classification: C07C,G01N,Y10S

Abstract:
A reagent having the general formula of General Formula I: ##STR45## wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species;wherein group R.sub.2 is selected from one of H and OH moieties;wherein group R.sub.3 is selected from one of an alkyl and a methylene bearing an electronegative substituent;wherein group Z is a spacer selected from one of (CH.sub.2).sub.n and CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.n.sbsb.2, and n is an integer of from 1 to 5, and n.sub.2 is an integer of from 1 to 4; andwherein each of group Z.sub.2 and Z.sub.3 is a spacer selected from one of CH.sub.2, CH.sub.2 CONHCH.sub.2, CH.sub.2 CONH(CH.sub.2).sub.n.sbsb.3 CONHCH.sub.2, and (CH.sub.2).sub.n.sbsb.4 NHCO(CH.sub.2).sub.n.sbsb.5 CONHCH.sub.2, and n.sub.3 is an integer of from 1 to 5, n.sub.4 is an integer selected from one of 2 and 3, and n.sub.5 is an integer of from 1 to 4.