Patent ID: 8563022
Filing Date: 2013-10-22
Classification: A61K,A61P

Abstract:
1. A method of designing and fabricating particles having an enhanced adherence to cells of a target site, the method comprising (A) selecting a target site having a surface, said surface having one or more first moieties; (B) selecting second moieties that are capable of binding to the first moieties; (C) selecting a numerical value for a spheroid aspect ratio of a spheroidal particle; (D) calculating the numerical value of volume that maximizes the adherence strength of the spheroidal particle to the target site using the following input parameters; (i) the selected numerical value of the spheroid aspect ratio; (ii) the area of interaction ¶r (E) fabricating the spheroidal particle, that has a spheroid aspect ratio substantially equal to the selected numerical value and a volume that has a numerical value that is substantially equal to the calculated numerical value of the maximizing volume; and (F) disposing the second moieties on a surface of the particle wherein the particles obtained have an enhanced adherence to cells of the target site.