Patent ID: 8318899
Filing Date: 2012-11-27
Classification: A61K,A61P,C07K

Abstract:
1. A fusion construct comprising a first lytic domain and a second domain, wherein said first lytic domain consists of peptide KFAKFAKKFAKFAKKFA (SEQ ID NO:3), or KFAKFAKKFAKFAKKFAKF (SEQ ID NO.5) or KFAKFAKKFAKFAKKFAKFA (SEQ ID NO.6); and said second domain comprises a binding moiety, wherein the binding moiety comprises a luteinizing hormone releasing hormone (LHRH), a LHRH analogue, a fragment of a LHRH, or a fragment of a LHRH analogue that binds to a LHRH receptor, or wherein the binding moiety comprises a chorionic gonadotropin beta subunit (β-CG), a β-CG analogue, a fragment of a β-CG or a β-CG analogue that binds to a luteinizing hormone (LH)/chorionic gonadotropin (CG) receptor.