Patent ID: 7867994
Filing Date: 2011-01-11
Classification: A61P,C07D

Abstract:
1. A process for the synthesis of ivabradine, 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of formula (I): and addition salts thereof with a pharmaceutically acceptable acid, wherein the compound of formula (V): wherein R is subjected to a catalytic hydrogenation reaction, and then the compound of formula (VI) thereby obtained: wherein R is subjected to a reaction with the compound of formula (VII): wherein HX represents a pharmaceutically acceptable acid, in the presence of hydrogen and a catalyst, to yield directly, after filtering off the catalyst and isolation, the addition salt of ivabradine with the acid HX, which is optionally subjected, when it desired to obtain free ivabradine, to the action of a base.