Patent ID: 8658653
Filing Date: 2014-02-25
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A method for treating a B-cell malignancy in a subject in need thereof comprising administering to the subject two or more agents, wherein the first agent is an irreversible inhibitor of Bruton's tyrosine kinase (Btk) and the second agent is selected from paclitaxel, amrubicin, or azacitidine, wherein the irreversible Btk inhibitor is a compound having the structure of Formula (A): wherein: A is N; R R R wherein, R 6 , R 7 and R 8 are independently selected from among H, lower alkyl or substituted lower alkyl, lower heteroalkyl or substituted lower heteroalkyl, substituted or unsubstituted lower cycloalkyl, and substituted or unsubstituted lower heterocycloalkyl; R each R two R R R