Patent ID: 6127379
Filing Date: 2000-10-03
Classification: C07D

Abstract:
A compound of formula (I), or a pharmaceutically acceptable salt thereof ##STR7## in which X.sub.1 --(CH.sub.2).sub.x --X.sub.2 and the aromatic carbon atoms to which they are attached form a 5-7 membered ring,wherein:one of X.sub.1 and X.sub.2 is O or S, and the other is CH.sub.2 ;x is 1, 2 or 3;R.sub.1 is hydrogen, amino, halo, C.sub.1-6 alkyl, hydroxy or C.sub.1-6 alkoxy;R.sub.2 is hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro, amino or C.sub.1-6 alkylthio;R.sub.3 is hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or amino;R.sub.4 and R.sub.5 are independently hydrogen or C.sub.1-6 alkyl;Y is O or NH;Z is of sub-formula (a): ##STR8## wherein R.sub.a.sup.1 is C.sub.1-12 alkyl or benzyl, unsubstituted or substituted by one or more substituents selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy.