Patent ID: 8785466
Filing Date: 2014-07-22
Classification: A61K,G01N

Abstract:
1. A method utilizing proteinacious channels in a lipid membrane of a mammalian cell, the method comprising: administering a pharmaceutical to a lipid membrane of a mammalian cell; measuring an electrical activity across the lipid membrane to determine an effect of the pharmaceutical on the electrophysiology of arterial Kv7 potassium channels of the lipid membrane; and then identifying pharmaceutical treatments for hypertensive, cancer, vasospastic, or cardiovascular medical conditions or risks of the pharmaceutical based on the electrical activity caused by the pharmaceutical, wherein the medical conditions are affected by the electrophysiology of arterial Kv7 potassium channels; and wherein pharmaceutical treatments for hypertensive, cancer, vasospastic, or cardiovascular medical conditions are identified if the effect of the pharmaceutical is to activate the arterial Kv7 potassium channels during the step of measuring the electrical activity, and risks of the pharmaceutical are identified if the effect of the pharmaceutical is to inhibit the arterial Kv7 potassium channels during the step of measuring the electrical activity.