Patent ID: 7714131
Filing Date: 2010-05-11
Classification: C07D

Abstract:
1. A method for preparing a compound of formula (I): wherein R each R the subscript n is 1 when R the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R the method comprising: (a) contacting a compound of formula (II): with a carboxylic acid activating reagent selected from the group consisting of thionyl halides, anhydrides and thioester generating reagents; in a compatible solvent; (b) brominating the product of step (a) with bromine in a compatible solvent; (c) esterifying the product of step (b) with a chiral alcohol selected from the group consisting of: in a compatible solvent to stereoselectively produce a compound of formula (I).