Patent ID: 7105531
Filing Date: 2006-09-12
Classification: C07D,C07F

Abstract:
1. A compound of formula 1 having the structure: wherein: Ar is a phenyl ring; wherein the phenyl ring may be optionally mono-, di-, or tri-substituted with substituent(s) independently selected from the group consisting of halogen, alkyl of 1–6 carbon atoms, alkenyl of 2–6 carbon atoms, alkynyl of 2–6 carbon atoms, azido, hydroxyalkyl of 1–6 carbon atoms, halomethyl, alkoxymethyl of 2–7 carbon atoms, alkanoyloxymethyl of 2–7 carbon atoms, alkoxy of 1–6 carbon atoms, alkylthio of 1–6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, alkoxycarbonyl of 2–7 carbon atoms, alkanoyl of 2–7 carbon atoms, benzoyl, amino, alkylamino of 1–6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, alkanoylamino of 1–6 carbon atoms, alkenoylamino of 3–8 carbon atoms, alkynoylamino of 3–8 carbon atoms, alkanoyloxy of 1–6 carbon atoms, alkenoyloxy of 3–8 carbon atoms, alkynoyloxy of 3–8 carbon atoms, carbamoyl, N-alkylcarbamoyl of 2–7 carbon atoms, N,N-dialkylcarbamoyl of 3–13 carbon atoms, carboxyalkyl of 2–7 carbon atoms, carboalkoxyalkyl of 3–8 carbon atoms, aminoalkyl of 1–5 carbon atoms, N-alkylaminoalkyl of 2–9 carbon atoms, N,N-dialkylaminoalkyl of 3–10 carbon atoms, N-alkylaminoalkoxy of 3–9 carbon atoms, N,N-dialkylaminoalkoxy of 4–10 carbon atoms, mercapto, methylmercapto and benzoylamino; or Ar is the radical: A T is substituted on A′ at carbon and is —NH(CH L is a phenyl ring that is optionally substituted with one, two, or three substituent(s) independently selected from the group consisting of alkyl of 1–6 carbon atoms, alkenyl of 2–6 carbon atoms, alkynyl of 2–6 carbon atoms, azido, hydroxyalkyl of 1–6 carbon atoms, halogen, halomethyl, alkoxymethyl of 2–7 carbon atoms, alkanoyloxymethyl of 2–7 carbon atoms, alkoxy of 1–6 carbon atoms, alkylthio of 1–6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, alkoxycarbonyl of 2–7 carbon atoms, alkanoyl of 2–7 carbon atoms, phenoxy, phenyl, thiophenoxy, benzoyl, benzyl, amino, alkylamino of 1–6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, phenylamino, benzylamino, alkanoylamino of 1–6 carbon atoms, alkenoylamino of 3–8 carbon atoms, alkynoylamino of 3–8 carbon atoms, carboxyalkyl of 2–7 carbon atoms, carboalkoxyalkyl of 3–8 carbon atoms, aminoalkyl of 1–5 carbon atoms, N-alkylaminoalkyl of 2–9 carbon atoms, N,N-dialkylaminoalkyl of 3–10 carbon atoms, N-alkylaminoalkoxy of 3–9 carbon atoms, N,N-dialkylaminoalkoxy of 4–10 carbon atoms, mercapto, methylmercapto, alkanoyloxy of 1–6 carbon atoms, alkenoyloxy of 3–8 carbon atoms, alkynoyloxy of 3–8 carbon atoms, carbamoyl, N-alkylcarbamoyl of 2–7 carbon atoms, N,N-dialkylcarbamoyl of 3–13 carbon atoms, and benzoylamino; m is 0–3; n is 0–1; X is NH or NR; R is alkyl of 1–6 carbon atoms; Y and Z are both carbon; A and D are each N; B is carbon; the dashed line indicates an optional double bond; R R V is (CH R M is NR W is NR Het is a heterocycle selected from the group consisting of morpholine, thiomorpholine, thiomorpholine S-oxide, thiomorpholine S,S-dioxide, piperidine, pyrrolidine, aziridine, pyridine, imidazole, 1,2,3-triazole, 1,2,4-triazole, thiazole, thiazolidine, tetrazole, piperazine, furan, thiophene, tetrahydrothiophene, tetrahydrofuran, dioxane, 1,3-dioxolane pyrrole, and tetrahydropyran; wherein the heterocycle is optionally mono- or di-substituted on carbon or nitrogen with R6; optionally mono- or di-substituted on carbon with hydroxy, —N(R Ph is a phenyl ring optionally mono-, di- or tri-substituted with halogen, alkyl of 1–6 carbon atoms, trifluoromethyl, nitro, cyano, azido, halomethyl, carboxyl, alkoxycarbonyl, alkylthio, mercapto, mercaptomethyl, —N(R R R J is independently hydrogen, chlorine, fluorine, or bromine; g=1–6; k=0–4; p=2–4; q=0–4; r=1–4; s=1–6; or a pharmaceutically acceptable salt thereof; provided that at least one of the bonds between A and B or B and D must be a double bond, with the other being a single bond; provided that when R provided that when R provided that when V is NR provided that when M is O or S and R provided that when V is NR provided that when V is O or S and M or W is O or S, then k=1–4 provided that when W is not a bond with Het bonded through a nitrogen atom then q =2–4; and provided that when W is a bond with Het bonded through a nitrogen atom and V is O or NR