Patent ID: 6451785
Filing Date: 2002-09-17
Classification: A61K,A61P

Abstract:
A method of inhibiting or reducing cell proliferation in a human or mammal, in need of such treatment, which method comprises administering to said human or mammal an effective CoA-independent transacylase (CoA-IT) inhibiting amount of a compound of the formula: whereinY is NH; X is O or S(O)m; m is 0 or an integer having a value of 1, or 2; R3 is optionally substituted triphenylmethyl; R4 is optionally substituted C1-10 alkyl, (CR10R20)nâ€”Câ‰¡Câ€”R5, or (CR10R20)nC(R10)&boxH;C(R7)2; n is an integer having a value of 1 to 4; R10 and R20 are independently hydrogen or C1-4 alkyl; R5 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, C(O)2R6, or C(O)R6, wherein the alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl moieties may be optionally substituted; R6 is C1-10 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic, or heterocyclicalkyl, wherein the alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic, or heterocyclicalkyl moieties may be optionally substituted; R7 is independently hydrogen, C1-10 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic, or heterocyclicalkyl, wherein the alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic, or heterocyclicalkyl moieties may be optionally substituted; or a pharmaceutically acceptable salt thereof.