Patent ID: 6524613
Filing Date: 2003-02-25
Classification: A61K,A61P,C12Q

Abstract:
A composition comprising:a) a recombinagenic oligonucleobase, which comprises a first and a second homologous region, which regions are homologous with a target gene of a mammal and a heterologous region, which is heterologous with the target gene and which contains an alteration disposed between the first and the second homologous region; b) an aqueous carrier; and c) a macromolecular carrier, which comprises a ligand for a clathrin-coated pit receptor, wherein the macromolecular carrier is selected from the group consisting of: (i) an aqueous-cored lipid vesicle, wherein the aqueous core contains the oligonucleobase, (ii) a lipid nanosphere, which comprises a lipophilic salt of the oligonucleobase, and (iii) a polycation having an average molecular weight of between 500 daltons and 1.3 Md wherein the polycation forms a salt with the oligonucleobase.