Patent ID: 8859850
Filing Date: 2014-10-14
Classification: A61P,C12N

Abstract:
1. A polynucleotide comprising two sequence pairs (a1-a2) and (b2-b1) separated by a spacer sequence wherein: (a) the sequences a1, a2, b1, and b2 differ among themselves and are selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4; (b) if a1 is SEQ ID NO: 1 or SEQ ID NO: 4, then b1 is SEQ ID NO: 4 or SEQ ID NO: 1, a2 is SEQ ID NO: 2 or SEQ ID NO: 3, and b2 is SEQ ID NO: 3 or SEQ ID NO: 2; and (c) if a1 is SEQ ID NO: 2 or SEQ ID NO: 3, then b1 is SEQ ID NO: 3 or SEQ ID NO: 2, a2 is SEQ ID NO: 1 or SEQ ID NO: 4, and b2 is SEQ ID NO: 4 or SEQ ID NO: 1.