Patent ID: 8361970
Filing Date: 2013-01-29
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a subject suffering from, or at risk of, restenosis, comprising administering to the subject an effective amount of a growth factor binding compound or a pharmaceutically acceptable salt thereof, or a composition comprising the growth factor binding compound, wherein R is substituted or unsubstituted n-butyl, n-propyl, benzyl, (C 1 -C 12 ) alkyl, (C 7 -C 18 ) aralkyl, (C 6 -C 18 ) aryl, (C 1 -C 12 ) alkenyl, (C 7 -C 18 ) aralkenyl, or (C 1 -C 12 ) alkylether, and X are each independently cyclic peptide loops of the general structure: wherein R 1 , R 2 , R 3 , and R 4 are each amino acid side chains that define a tetrapeptide, wherein said tetrapeptide is covalently attached at the amino and carboxy termini of said tetrapeptide to a 3-aminomethyl-5-aminobenzamide linking group, and wherein said tetrapeptide is GDFD (SEQ ID NO. 1), GDDD (SEQ ID NO. 2), D-ADGD (SEQ ID NO. 3), GDLD (SEQ ID NO. 4), GDAD (SEQ ID NO. 5), GDGY (SEQ ID NO. 6), ADGD (SEQ ID NO. 7), GDSD (SEQ ID NO. 8), GKGF (SEQ ID NO. 9), GKGK (SEQ ID NO. 10), GDND (SEQ ID NO. 11), PDGD (SEQ ID NO. 12), GDDG (SEQ ID NO. 13), or GDDY (SEQ ID NO. 14), wherein the compound inhibits, prevents or ameliorates restenosis.