Patent ID: 6894042
Filing Date: 2005-05-17
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: wherein Azabicyclo is R R k is 1 or 2, provided that when k is 2, each R R W W Each R m is 1 or 2, provided that when m is 2 each R R or R  wherein each A is independently CR R or R R Each R R Each R Each R R R Each R R Each R Aryl is phenyl, substituted phenyl, naphthyl, or substituted naphthyl; Substituted phenyl is a phenyl either having 1-4 substituents independently selected from F, Cl, Br, or I, or having 1 substituent selected from R Substituted naphthyl is a naphthalene moiety either having 1-4 substituents independently selected from F, Cl, Br, or I, or having 1 substituent selected from R Alkyl is both straight- and branched-chain moieties having from 1-6 carbon atoms; Lower alkyl is both straight- and branched-chain moieties having from 1-4 carbon atoms; Halogenated alkyl is an alkyl moiety having from 1-6 carbon atoms and having 1 to (2n+1) substituent(s) independently selected from F, Cl, Br, or I Where n is the maximum number of carbon atoms in the moiety; Lower halogenated alkyl is an alkyl moiety having from 1-4 carbon atoms and having 1 to (2n+1) substituent(s) independently selected from F, Cl, Br, or I where n is the maximum number of carbon atoms in the moiety; Substituted alkyl is an alkyl moiety from 1-6 carbon atoms and having 0-3 substituents independently selected from R Lower substituted alkyl is lower alkyl having 0-3 substituents independently selected from F, Cl, Br, or I, and further having 1 substituent selected from —OR wherein each R wherein any lower alkyl, cycloalkyl, heterocycloalkyl, or phenyl is optionally substituted with up to two halogens independently selected from F or Cl and up to one other substituent independently selected from —OR and wherein each R Alkenyl is straight- and branched-chain moieties having from 2-6 carbon atoms and having at least one carbon-carbon double bond; Lower alkenyl is straight- and branched-chain moieties having from 2-4 carbon atoms and having at least one carbon-carbon double bond; Halogenated alkenyl is an unsaturated alkenyl moiety having from 2-6 carbon atoms and having 1 to (2n−1) substituent(s) independently selected from F, Cl, Br, or I where n is the maximum number of carbon atoms in the moiety; Lower halogenated alkenyl is an unsaturated alkenyl moiety having from 2-4 carbon atoms and having 1 to (2n−1) substituent(s) independently selected from F, Cl, Br, or I where n is the maximum number of carbon atoms in the moiety; Substituted alkenyl is an unsaturated alkenyl moiety having from 2-6 carbon atoms and having 0-3 substituents independently selected from F, or Cl, and further having 1 substituent selected from R Lower substituted alkenyl is lower alkenyl having 0-3 substituents independently selected from F, Cl, Br, or I, and further having 1 substituent selected from R wherein each R wherein any lower alkyl, cycloalkyl, heterocycloalkyl, or phenyl is optionally substituted with up to two halogens independently selected from F or Cl and up to one other substituent independently selected from —OR and wherein each R Alkynyl is straight- and branched-chained moieties having from 2-6 carbon atoms and having at least one carbon-carbon triple bond; Lower alkynyl is straight- and branched-chained moieties having from 2-6 carbon atoms and having at least one carbon-carbon triple bond; Halogenated alkynyl is an unsaturated-alkynyl- moiety having-from 3-6-carbon atoms and having 1 to (2n−3) substituent(s) independently selected from F, Cl, Br, or I where n is the maximum number of carbon atoms in the moiety; Lower halogenated alkynyl is an unsaturated alkynyl moiety having from 3-4 carbon atoms and having 1 to (2n−3) substituent(s) independently selected from F, Cl, Br, or I where n is the maximum number of carbon atoms in the moiety; Substituted alkynyl is an unsaturated alkynyl moiety having from 3-6 carbon atoms and having 0-3 substituents independently selected from F, or Cl, and further having 1 substituent selected from R Lower substituted alkynyl is lower alkynyl having 0-3 substituents independently selected from F, or Cl, and further having 1 substituent selected from R wherein each R wherein any lower alkyl, cycloalkyl, heterocycloalkyl, or phenyl is optionally substituted with up to two halogens independently selected from F or Cl and up to one other substituent independently selected from —OR and wherein each R Cycloalkyl is a cyclic alkyl moiety having from 3-6 carbon atoms; Halogenated cycloalkyl is a cyclic moiety having from 3-6 carbon atoms and having 1-4 substituents independently selected from F, or Cl; Substituted cycloalkyl is a cyclic moiety having from 3-6 carbon atoms and having 0-3 substituents independently selected from F, or Cl, and further having 1 substituent selected from —OR Heterocycloalkyl is a cyclic moiety having 4-7 atoms with 1-2 atoms within the ring being —S—, —N(R Halogenated heterocycloalkyl is a cyclic moiety having from 4-7 atoms with 1-2 atoms within the ring being —S—, —N(R Substituted heterocycloalkyl is a cyclic moiety having from 4-7 atoms with 1-2 atoms within the ring being —S—, —N(R Lactam heterocycloalkyl is a cyclic moiety having from 4-7 atoms with one atom being only nitrogen with the bond to the lactam heterocycloalkyl thru said atom being only nitrogen and having a ═O on a carbon adjacent to said nitrogen, and having up to 1 additional ring atom being oxygen, sulfur, or nitrogen and further having 0-2 substituents selected from F, Cl, Br, I, or R or pharmaceutical composition, pharmaceutically acceptable salt, racemic mixture, and pure enantiomer thereof.