Patent ID: 9005885
Filing Date: 2015-04-14
Classification: A61L,A61M,C12M

Abstract:
1. A method of providing a fuctional bioartificial airway organ, the method comprising: providing a decellularized lung tissue matrix comprising airway and vascular architecture; seeding a lumen of the vascular architecture by perfusing endothelial cells through the vascular architecture; seeding the lung tissue matrix with epithelial cells over the airway architecture through a wet ventilation line; providing the lung tissue matrix with wet ventilation, through the airway architecture, and perfusion, through the vascular architecture, for a time sufficient to produce a wet-matured organ; and providing the wet-matured organ with dry ventilation through the airway architecture, and with perfusion through the vascular architecture, for a time sufficient for providing a functional bioartifical lung that allows for the exchange of oxygen.