Patent ID: 6620837
Filing Date: 2003-09-16
Classification: C07D

Abstract:
A compound of formula I (or a pharmaceutically acceptable salt thereof) whereinA is carbonyl or methylene; Rd is â€”[Oâ€”(CH2)d]câ€”Rc in which c is 0 or 1; d is 1, 2, or 3; and Rc is carboxy, [(1-4C)alkoxy]carbonyl, hydroxymethyl or carbamoyl; provided that if c is 0, Rc is carboxy, [(1-4C)alkoxy]carbonyl or carbamoyl; or Rd is â€”[Oâ€”(CH2)d]câ€”Rc in which c is 1; d is 1, 2, or 3; and Rc is carboxy, [(1-4C)alkoxy]carbonyl, hydroxymethyl or carbamoyl; Re is hydrogen, methyl, methoxy or halo; R2 is R2a or R2b in which R2a is â€”X2â€”(CH2)nâ€”Rf in which X2 is a direct bond, methylene or O; n is 1, 2 or 3; and Rf is 5-tetrazolyl, carboxy, [(1-4C)alkoxy]carbonyl or hydroxymethyl; R2b is â€”X2â€”(CH2)mâ€”NRaRb in which X2 is a direct bond, methylene or O; m is 1, 2 or 3; provided that when m is 1, then X2 is a direct bond; and Ra and Rb are independently hydrogen or (1-3C)alkyl or the group NRaRb is pyrrolidino, piperidino or morpholino; R3 is R3a or R3b in which R3a is 2-(2-oxopyrolidin-1-yl)ethoxy; provided that R2 is R2b when R3 is R3a; R3b is â€”X3â€”(CH2)sâ€”NRsRt in which X3 is a direct bond, methylene or O; s is 1 or 2; provided that when s is 1, then X3 is a direct bond; and Rs and Rt are independently hydrogen or (1-3C)alkyl or the group NRsRt is pyrrolidino, piperidino or morpholino; and R6 is hydrogen, hydroxy or methoxy.