Patent ID: 6808876
Filing Date: 2004-10-26
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
A method of identifying a compound that modulates the activity of a cellular regulator comprising, contacting a sample containing a cellular regulator and a nucleic acid element acted on by the cellular regulator with a test compound under conditions that allow replication or expression of the nucleic acid element or a gene operatively linked to the nucleic acid element, and measuring the amount of replication or expression of the nucleic acid element or gene, an increase or decrease in the amount of replication or expression in the presence of the test compound compared to the absence of the test compound indicates that the compound has cellular regulator modulatory activity wherein said cellular regulator is eIF2B&ggr; (SEQ ID NOS: 1, 2, 16 or 35) and said nucleic acid element is an internal ribosome entry site (IRES).