Patent ID: 6835754
Filing Date: 2004-12-28
Classification: A61K

Abstract:
A method for treating neuropathic pain in a patient comprising administering an effective neuropathic pain-treating dose of a pharmaceutical composition comprising a compound of formula I: whereinR1 is each R2 is independently selected from a group of the formula: R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl; R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R8 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; or R8 and R9 can be joined to form an alkylene or substituted alkylene group having from 2 to 10 carbon atoms; R10 is selected from the group consisting of hydrogen, lower alkyl and lower cycloalkyl; or R1 and R10 can be joined to form an alkylene, substituted alkylene, â€”C(O)â€”S(O)â€” or â€”S(O)2â€” group; R11 and R12 are independently selected from the group consisting of lower alkyl and lower cycloalkyl; or R11 and R12 can be joined to form an alkylene group having from 2 to 10 carbon atoms; and X is oxygen, sulfur, â€”S(O)â€” or â€”S(O)2â€”, or a pharmaceutically-acceptable salt thereof.