Patent ID: 6248716
Filing Date: 2001-06-19
Classification: A61K,C07K

Abstract:
A method for preventing or reducing conditions or complications resulting from stress in an animal in need thereof, comprising administering to said animal an effective amount of a peptide of the formula I,X-Tyr-Y-Phe-Z-A Iwherein X is hydrogen, arginine, D-arginine, ornithine, D-ornithine, lysine, D-lysine, homoarginine, D-homoarginine, citrulline, D-citrulline; Tyr is tyrosine; Y is D-alanine, D-valine, D-leucine, D-isoleucine, D-phenylalanine, D-asparagine, D-tryptophan, D-proline, D-serine, D-threonine, D-tyrosine, D-hydroxyproline, D-cysteine, D-cysteyl-cysteine, D-methionine, D-lysine, D-homoarginine, D-arginine, D-histidine, D-aspartic acid, D-glutamic acid, D-.beta.-alanine, or D-ornithine Phe is phenylalanine; Z is alanine, D-alanine, valine, D-valine, leucine, D-leucine, isoleucine, D-isoleucine, phenylalanine, D-phenylalanine, asparagine, D-asparagine, glycine, glutamine, D-glutamine, tryptophan, D-tryptophan, proline, D-proline, serine, D-serine, threonine, D-threonine, tyrosine, D-tyrosine, hydroxyproline, D-hydroxyproline, cysteine, D-cysteine, cysteyl-cysteine, cysteine-D-cysteine, D-cysteyl-cysteine, D-cysteine-D-cysteine, methionine, D-methionine, lysine, D-lysine, arginine, D-arginine, histidine, D-histidine, aspartic acid, D-aspartic acid, glutamic acid, D-glutamic acid, .beta.-alanine, D-.beta.-alanine, ornithine, or D-ornithine; and A is hydroxyl or an amide which may be substituted, wherein when X is H and Y is D-Arg Z-A is not Lys-NH.sub.2 ; and when X is H, and Y is Pro, Z-A is not Pro-OH or Pro-NH.sub.2.