Patent ID: 6090365
Filing Date: 2000-07-18
Classification: A61K,C07K,G01N

Abstract:
A method for the treatment of lymphoma which comprises:first administering to a patient an unlabelled antibody or antibody fragment having the ability to bind to the CD20 antigen present on lymphoma cells; andsubsequently administering to a patient a radioimmunotherapeutically effective amount of an antibody or antibody fragment having a radioactive label, the labelled antibody or antibody fragment having the ability to bind to the CD20 antigen present on lymphoma cells wherein the amount of radioactivity is less than the amount that provides irradiation at a dose which causes myelosuppression severe enough to require the reintroduction of hematopoietic stem cells into the patient in order for the patient to recover hematopoietic function after administration of the labelled antibody or antibody fragment which is administered in the radioimmunotherapeutically effective amount.