Patent ID: 9134328
Filing Date: 2015-09-15
Classification: A61P,C07D,G01N

Abstract:
1. A method for distinguishing an Alzheimer's diseased brain from a normal brain comprising: (i) obtaining tissues from the cerebellum and another area of the same brain, of a normal mammal and of a mammal suspected of having Alzheimer's disease; (ii) contacting the tissues with a compound of formula I; (iii) quantifying the amyloid bound to the compound; (iv) calculating the ratio of (a) the amount of amyloid in the area of the brain other than the cerebellum to (b) the amount of amyloid in the cerebellum; and (v) comparing the ratio for a normal mammal with the ratio for a mammal suspected of having Alzheimer's disease, wherein the compound of formula I is represented by formula I or a pharmaceutically acceptable salt of the compound, wherein: R R is C R R R