Patent ID: 6180134
Filing Date: 2001-01-30
Classification: A61K,Y10S

Abstract:
A liposome composition for use in treating a condition mediated by binding of one binding member, which is a pathogen or cell in the bloodstream, to a second binding member, which is a target cell or cell matrix, comprisingliposomes having an outer surface layer of polyethylene glycol chains, each chain having a free distal end, andcovalently attached to a portion of said distal chain ends, a polypeptide or polysaccharide effector molecule which (i) interferes with specific binding between said first and second binding members, and (ii) is rapidly removed by renal clearance from the bloodstream when administered in free form,wherein binding of the liposomes to one of said first or second binding members is effective to inhibit binding between said first and second binding members.