Patent ID: 7666674
Filing Date: 2010-02-23
Classification: A61K,A61P,Y02A

Abstract:
1. A sterically stabilized cationic liposome composition, comprising a cationic lipid, a co-lipid, and a stabilizing agent encapsulating a K-type oligodeoxynucleotide of at least ten nucleotides in length comprising a CpG motif, wherein the K-type oligodeoxynucleotide comprising a CpG motif comprises a sequence represented by the formula 5′N 1 N 2 N 3 Q-CpG-WN 4 N 5 N 6 3′(SEQ ID NO: 97), wherein Q is a T, G, or A, W is A or T, and N 1 , N 2 , N 3 , N 4 , N 5 , and N 6 are any nucleotide, and the lipid:co-lipid:stabilizing agent molar ratio is 4:6:0.06, wherein the lipid is dimethyaminoethane-carbamol-cholesterol, the co-lipid is dioleyl phosphatidyl ethanolamine, and the stabilizing agent is a polyethylene glycol: phosphatidyl ethanolamine.