Patent ID: 8598343
Filing Date: 2013-12-03
Classification: A61P,C07D

Abstract:
1. A process for preparing the compound having the structural Formula I: comprising: (i) preparing a compound of Formula II: using a process comprising: (a) treating a compound V with triethyl orthoformate to obtain imidate VI: (b) condensing imidate VI with 2-butynoylhydrazine p-toluenensulfonate (VII) to obtain the adduct compound VIII: (c) cyclizing and dehydrating compound VIII with N,O-bistrimethylsilyl acetamide to obtain the 2-propynyl-substituted compound IX: and (d) hydrolyzing compound IX to obtain compound II; (ii) condensing compound II with compound III to obtain compound IV (iii) cyclizing compound IV to obtain compound I; and (iv) optionally purifying the product of step (iii).