Patent ID: 6713482
Filing Date: 2004-03-30
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein Ar is a 6-membered monocyclic aromatic ring having two N atoms; and said heteroaryl being connected to the nitrogen atom on the benzimidazole through a carbon atom on the heteroaryl ring; X1 is independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halo-substituted C1-C4 alkyl, hydroxy-substituted C1-C4 alkyl, (C1-C4 alkoxy)C1-C4 alkyl, halo-substituted C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino, N,N-di(C1-C4 alkyl)amino, [N-(C1-C4 alkyl)amino]C1-C4 alkyl, [N,N-di(C1-C4 alkyl)amino]C1-C4 alkyl, Nâ€”(C1-C4 alkanoyl)amino, Nâ€”(C1-C4 alkyl)-Nâ€”(C1-C4 alkanoyl)amino, Nâ€”[(C1-C4 alkyl)sulfonyl]amino, N-[(halo-substituted C1-C4 alkyl)sulfonyl]amino, C1-C4 alkanoyl, carboxy, (C1-C4 alkoxy)carbonyl, carbamoyl, [Nâ€”(C1-C4 alkyl)amino]carbonyl, [N,N-di(C1-C4 alkyl)amino]carbonyl, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, [Nâ€”(C1-C4 alkyl)amino]sulfonyl and [N,N-di(C1-C4 alkyl)amino]sulfonyl; X2 is independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halo-substituted C1-C4 alkyl, hydroxy-substituted C1-C4 alkyl, (C1-C4 alkoxy)C1-C4 alkyl, halo-substituted C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino, N,N-di(C1-C4 alkyl)amino, [Nâ€”C1-C4 alkyl)amino]C1-C4 alkyl, [N,N-di(C1-C4 alkyl)amino]C1-C4 alkyl, Nâ€”(C1-C4 alkanoyl)amino, Nâ€”(C1-C4 alkyl)-Nâ€”(C1-C4 alkanoyl)amino, Nâ€”[(C1-C4 alkyl)sulfonyl]amino, N-[(halo-substituted C1-C4 alkyl)sulfonyl]amino, C1-C4 alkanoyl, carboxy, (C1-C4 alkoxy)carbonyl, carbamoyl, [Nâ€”(C1-C4 alkyl)amino]carbonyl, [N,N-di(C1-C4 alkyl)amino]carbonyl, N-carbamoylamino, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, [Nâ€”(C1-C4 alkyl)amino]sulfonyl and [N,N-di(C1-C4 alkyl)amino]sulfonyl; R1 is selected from hydrogen; straight or branched C1-C4 alkyl optionally substituted with one to three substituent(s) wherein said substituents are independently selected from halo, hydroxy, C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino and N,N-di(C1-C4 alkyl)amino; C3-C8 cycloalkyl optionally substituted with one to three substituent(s) wherein said substituents are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino and N,N-di(C1-C4 alkyl)amino; C4-C8 cycloalkenyl optionally substituted with one to three substituent(s) wherein said substituents are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino and N,N-di(C1-C4 alkyl)amino; phenyl optionally substituted with one to three substituent(s) wherein said substituents are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halo-substituted C1-C4 alkyl, hydroxy-substituted C1-C4 alkyl, (C1-C4 alkoxy)C1-C4 alkyl, halo-substituted C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino, N,N-di(C1-C4 alkyl)amino, [Nâ€”(C1-C4 alkyl)amino]C1-C4 alkyl, [N,N-di(C1-C4 alkyl)amino]C1-C4 alkyl, Nâ€”(C1-C4 alkanoyl)amino, Nâ€”[(C1-C4 alkyl)(C1-C4 alkanoyl)]amino, Nâ€”[(C1-C4 alkyl)sulfonyl]amino, N-[(halo-substituted C1-C4 alkyl)sulfonyl]amino, C1-C4 alkanoyl, carboxy, (C1-C4 alkoxy)carbonyl, carbamoyl, [Nâ€”(C1-C4 alkyl)amino]carbonyl, [N,N-di(C1-C4 alkyl)amino]carbonyl, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, [Nâ€”(C1-C4 alkyl)amino]sulfonyl and [N,N-di(C1-C4 alkyl)amino]sulfonyl; and R2 and R3 are independently selected from: hydrogen; halo; C1-C4 alkyl; phenyl optionally substituted with one to three substituent(s) wherein said substituents are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino, Nâ€”(C1-C4 alkyl)amino and N,N-di(C1-C4 alkyl)amino; or R1 and R2 can form, together with the carbon atom to which they are attached, a C3-C7 cycloalkyl ring; m is 0, 1, 2, 3, 4 or 5; and n is 0, 1, 2, 3 or 4.