Patent ID: 6656958
Filing Date: 2003-12-02
Classification: A61K,C07D,C07F

Abstract:
A compound of the structure wherein n is an integer of 1 to 4;R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, alkynyl, aralkyl and cyanomethyl; R3, at each occurrence, is selected from the group consisting of hydrogen, haloalkyl and lower alkyl; R4, at each occurrence, is independently selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, and aralkyl; R5 is selected from the group consisting of hydrogen, halogen, lower alkyl, nitro, lower alkylamino and lower alkoxy; R6 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, alkenoxy, â€”CF3, carboxaldahyde, â€”CH&boxH;NOH, aryl, heterocyclyl, wherein the heterocyclyl is unsubstituted pyridinyl or pyridinyl substituted with alkenyl, and aralkenyl; and A is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”N(R1)â€”, â€”SO2N(R1)â€” and â€”NR1SO2â€”; and pharmaceutically acceptable salts thereof; with the proviso that when A=O at least one of R5 or R6 is halogen; and with the further proviso that when R3 and R4 are attached to a carbon which is alpha to a heteroatom, R4 is not halogen, hydroxyl or amino.