Patent ID: 8614296
Filing Date: 2013-12-24
Classification: A61K,A61P,C07K

Abstract:
1. A humanized antibody or an antigen-binding fragment thereof that immunospecifically recognizes the RGD sequence, comprising: (i) a H-chain comprising FRH1-4 of a VH of a human antibody, and the amino acid sequences of SEQ ID NOS: 1, 2 and 3 as CDRH1, CDRH2 and CDRH3 respectively; and (i) a L-chain comprising FRL1-4 of a VL of a human antibody, and the amino acid sequences of SEQ ID NOS: 4, 5 and 6 as CDRL1, CDRL2 and CDRL3 respectively, wherein said FRH1-4 consists of the amino acid sequences of SEQ ID NOS: 14, 15, 16 and 17, respectively, and said FRL1-4 consists of the amino acid sequences of SEQ ID NOS: 19, 20, 21 and 22, respectively.