Patent ID: 6414157
Filing Date: 2002-07-02
Classification: A61P,C07D

Abstract:
A compound of the formula I whereone of the two radicals X and Y is CH2 and the other is NR1, R1 is hydrogen, (C1-8) alkyl branched or unbranched, COâ€”(C1-4)-alkyl, CO2tBu, CO-aryl and a phenylalkyl-C1-C4 radical which in turn may be substituted on the aromatic system by F, Cl, Br, I, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, hydroxyl, amino, cyano or nitro, A is branched or unbranched (C1-10)-alkylene or straight-chain or branched (C2-10)-alkylene which comprises at least one group Z which is selected from O, S, NR2, cyclopropyl, CO2, CHOH, a double or triple bond, R2 is hydrogen and C1-C4 alkyl, B is 1,4-piperidinylene, 1,2,3,6-tetrahydro-1,4-pyridinylene, 1,4-piperazinylene or the corresponding cyclic compounds enlarged by one methylene group, with the linkage to A being via an N atom of B, and Ar is phenyl which is unsubstituted or substituted by (C1-6) alkyl branched or unbranched, Oâ€”(C1-8)-alkyl branched or unbranched, F, Cl, Br, I, trifluoromethyl, NR22, CO2R2, cyano or phenyl, or is tetratinyl, indanyl, fused aromatic systems.