Patent ID: 6777421
Filing Date: 2004-08-17
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is selected from the group consisting of hydrogen, C1-6alkyl, aryl and aralkyl; wherein the aryl or aralkyl group is optionally substituted with one to four substituents independently selected from halogen, C1-6alkyl, halogenated C1-6alkyl, C1-6alkoxy, nitro, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, C1-6alkylsulfonyl, amido, (C1-6alkyl)amido, di(C1-6alkyl)amido, sulfonyl, aminosulfonyl, (C1-6alkyl)aminosulfonyl, di(C1-6alkyl)aminosulfonyl or C3-8cycloalky; R2 is selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxyaminoC1-6alkyl, aminocarbonylC1-6alkyl, C1-6alkoxycarbonylC1-6alkyl, aryl, C3-8cycloalkyl, partially unsaturated carbocyclyl, C1-6aralkyl, and carbocyclylC1-6alkyl; wherein the alkyl group is optionally substituted with one to two substituents independently selected from hydroxy, carboxy, cyano, amino, C1-6alkylamino, di(C1-6alkyl)amino, hydroxyC1-6alkylamino, aminoC1-6alkylamino, C1-6alkylaminoC1-6alkylamino or di(C1-6alkyl)aminoC1-6alkylamino, wherein the aryl, cycloalkyl, or carbocyclyl, group is optionally substituted with one to four substituents independently selected from halogen, C1-6alkyl, halogenated C1-6alkyl, C1-6alkoxy, nitro, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, C1-6alkylsulfonyl, amido, (C1-6alkyl)amido, di(C1-6alkyl)amido, sulfonyl, aminosulfonyl, (C1-6alkyl)aminosulfonyl, di(C1-6alkyl)aminosulfonyl or C1-4alkoxycarbonyl; a is an integer from 0 to 2; R3 is selected from the group consisting of C1-4alkyl and hydroxy C1-4alkyl; n is an integer from 0 to 1; X is selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-4alkyl-O and C2-4alkyl-S; wherein the alkyl group is optionally substituted with one to two substituents independently selected from fluoro, C1-6alkyl, fluorinated C1-6alkyl, C1-6alkoxy, nitro, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, C1-6alkylsulfonyl, amido, (C1-6alkyl)amido, di(C1-6alkyl)amido, sulfonyl, aminosulfonyl, (C1-6alkyl)aminosulfonyl or di(C1-6alkyl)aminosulfonyl; and wherein X is C2-4alkyl-O or C2-4alkyl-S, the X group is incorporated into the molecule such that the C2-4alkyl is bound directly to the piperidine portion of the molecule; is phenyl;b is an integer from 0 to 1; R4 is selected from the group consisting of aryl, C3-8cycloalkyl, and partially unsaturated carbocyclyl; c is an integer from 0 to 3; R5 is selected from the group consisting of halogen, C1-6alkyl, halogenated C1-6alkyl, C1-6alkoxy, nitro, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, C1-6alkylsulfonyl, amido, (C1-6alkyl)amido, di(C1-6alkyl)amido, sulfonyl, aminosulfonyl, (C1-6alkyl)aminosulfonyl or di(C1-6alkyl)aminosulfonyl; m is 0; Y is selected from the group consisting of C1-4alkyl, C2-4alkenyl, O, S, NH, N(C1-4alkyl), C1-6alkyl-O, C1-6alkyl-S, Oâ€”C1-6alkyl and Sâ€”C1-6alkyl-S; R6 is a heteroaryl selected from the group consisting of furyl, thienyl, pyridyl and imidazolyl; wherein the heteroaryl group is optionally substituted with one to four substituents independently selected from halogen, hydroxy, C1-6alkyl, halogenated C1-6alkyl, C1-6alkoxy, nitro, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, C1-6alkylsulfonyl, amido, (C1-6alkyl)amido, di(C1-6alkyl)amido, sulfonyl, aminosulfonyl, (C1-6alkyl)aminosulfonyl, di(C1-6alkyl)aminosulfonyl or triphenylmethyl; and pharmaceutically acceptable salts thereof.