Patent ID: 6376529
Filing Date: 2002-04-23
Classification: A61K,A61P,C07D

Abstract:
A method of treating an insulin related disorder in an animal, which comprises administering to an animal in need thereof a therapeutically effective amount of a compound of formula I, II, or III: or a pharmaceutically acceptable salt thereof, wherein:A is monocyclic aryl, bicyclic aryl or heteroaryl; R1 and R2 are each independently Br, Cl, F, I, H, OH, or â€”OC(O)R, wherein R is lower alkyl, aryl or alkylaryl; R1â€³ and R2â€³ are each independently H, C1-C7 alkyl, C2-C7 alkenyl, C2-C7 alkynyl, alkylaryl or aryl; and R3 to R6 and R8 to R12 are each independently hydrogen, branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkenyl, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, mercapto, or 2-methylbut-2-en-4-yl; or a pharmaceutically acceptable salt thereof, wherein:A1 and A2 are each independently carboxy, monocyclic aryl, bicyclic aryl or heteroaryl; R1 and R2 are each independently Br, Cl, F, I, H, OH, or â€”OC(O)R, wherein R is lower alkyl, aryl or alkylaryl; R1â€³ and R2â€³ are each independently H, C1-C7 alkyl, C2-C7 alkenyl, C2-C7 alkynyl, alkylaryl or aryl; and R3 to R6 and R8 to R11 are each independently hydrogen, branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkenyl, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, mercapto, or 2-methylbut-2-en-4-yl, or a pharmaceutically acceptable salt thereof, wherein:R1 and R2 are each independently Br, Cl, F, I, H, OH, or â€”OC(O)R, wherein R is lower alkyl, aryl or alkylaryl; R1â€³ and R2â€³ are each independently H, C1-C7 alkyl, C2-C7 alkenyl, C2-C7 alkynyl, alkylaryl or aryl; and R4 to R6 and R9 to R11 are each independently hydrogen, branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkenyl, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, mercapto, or 2-methylbut-2-en-4-yl; R7 is branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, mercapto, or 2-methylbut-2-en-4-yl; R12 is branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkenyl, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, mercapto, or 2-methylbut-2-en-4-yl; and R3 and R8 are each independently hydrogen, branched or unbranched C1-C20 alkyl, alkylcarboxy, C2-C12 alkynyl, alkenylcarboxy, aryl, alkylaryl, hydroxy, hydroxyalkyl, C1-C12 alkoxy, nitro, halo, trihalomethyl, amido, carboxamido, carboxy, sulfonyl, sulfonamido, amino, or mercapto.