Patent ID: 6011014
Filing Date: 2000-01-04
Classification: A61K,C07K,C12N

Abstract:
A method of treating or preventing multiple sclerosis in a subject by administering an effective amount of the peptide:I-A-B-C-D-E-F-G-H-II (General Formula I)(SEQ ID No:1)whereasA is Ala, Gly, Val, Ser, Thr or absent,B is Ala, Gly, Val, Ser, Thr or absent,C is Ser, Thr or absent,D is Ser, Thr, Asn, Glu, Arg, Ile, Leu or absent,E is Ser, Thr, Asp or absent,F is Thr, Ser, Asn, Arg, Gln, Lys, Trp or absent,G is Tyr or absent;H is Thr, Arg, Gly, Met, Met(O), Gys, Thr, Gly or absent,andI is Cys or absent,II is Cys, and amide group, an ester group or absent, at least one of the amino acids optionally being substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino and/or an alkyl ester or alkyl ether amido groups of the amino acids, and wherein the peptide comprises at least 4 amino acid residues, or a pharmaceutically acceptable salt thereof.