Patent ID: 7166574
Filing Date: 2007-01-23
Classification: A61K,A61L,A61P,C07H,C07K

Abstract:
1. A synthetic heparin-binding growth factor (HBGF) analog comprising a molecule having the formula (I): wherein each X represents YRSRKYSSWYVALKR (SEQ ID NO:3), and n is 1; J J Y represents a linker that (i) is sufficiently hydrophobic to bind non-covalently to a polystyrene or polycaprolactone surface, (ii) comprises a chain of a minimum of about three and a maximum of about 17 residues, (iii) is not found in the natural ligand of the heparin-binding growth factor receptor (HBGFR), and (iv) is covalently bonded to J Z represents a peptide that comprises a heparin binding domain, comprising RKRKLERAIR (SEQ ID NO:2) and wherein the peptide analog has an avidity for heparin such that the synthetic heparin-binding growth factor analog binds heparin in 0.48M NaCl, but is eluted by 1M NaCl.