Patent ID: 8008329
Filing Date: 2011-08-30
Classification: A61K,A61P

Abstract:
1. A method of treating osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising the following compounds (a) and (b) for the purpose of using simultaneously, separately, or sequentially as active ingredients: (a) a benzamidine derivative represented by the following Formula 1 or salt thereof, and (b) bisphosphonate represented by the following Formula 2, wherein R straight or branched C  unsubstituted or substituted with hydroxy; C  group which is substituted with straight or branched C  (wherein A is C R  imidazolyl, or pyrrolidinyl; R R R  phenyl; benzyl; pyridinyl; carbonyl which is substituted with one group selected from C  or C R  carbonyl which is substituted with C R X Y is O, S, NR n is an integer of 0, 1 and 2, wherein R R M is hydrogen or sodium, and Z is any number, preferably an integer of 0 to 7.