Patent ID: 6495582
Filing Date: 2002-12-17
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:Ht is pyrrol-3-yl having R3 and QR4 substituents; Aâ€”B is Nâ€”O or Oâ€”N; R1 is hydrogen; T is a valence bond; Q is â€”C(O)â€”; each R is independently selected from hydrogen or an optionally substituted aliphatic group having one to six carbons; R2 is aryl substituted with one Lâ€”W substituent and up to three R8 substituents; L is a C1-6 alkylidene chain wherein up to two methylene units is replaced by â€”NHCOâ€”; W is CH(R9)N(R9)2; R3 is R, wherein R is hydrogen; R4 is â€”NHR6; R5 is hydrogen or an unsubstituted C1-6 aliphatic group; R6 is â€”(CH2)yCH(R7)2; y is 0-6; each R7 is independently selected from R, aryl, or hydroxyalkyl, wherein said aryl ring is optionally substituted with halogen, Râ€², ORâ€², CO2Râ€², or SO2Râ€², wherein each Râ€² is independently selected from hydrogen or a C1-6 aliphatic group; each R8 is independently selected from halogen; and each R9 is independently selected from R5.