Patent ID: 6525050
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound having the structure: wherein:R1is H or CN; R2 is phenyl or thienyl, each of which may be optionally substituted with phenyl, phenoxy, thienyl, tetrazolyl, or 4-morpholinyl; and R3 is phenyl substituted by â€”SO2NR5R6 or â€”NR5SO2R6 and optionally further substituted with lower alkyl, lower alkoxy, or halogen, wherein R5 is H or lower alkyl, R6 is lower alkyl, heteroarylalkyl, substituted or unsubstituted with one or more substituents chosen from the group consisting of hydroxy, halogens, oxo, alkyl, acyl, sulfonyl, mercapto, alkylthio, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carboxy, amino, alkylamino, dialkylamino, carbamoyl, aryloxy, heteroaryloxy, arylthio, and heteroarylthio, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or R3 is â€ƒwherein n is an integer of from 1 to 4, R4 is OH, lower alkoxy, or glutamic-acid or glutamate-alkylester linked through the amine functional group, or a pharmaceutically acceptable salt thereof.