Patent ID: 6136346
Filing Date: 2000-10-24
Classification: A61K,Y10S

Abstract:
A method of preparing a spray-dried, dispersible powdered pharmaceutical composition, comprising:spray-drying a homogeneous aqueous mixture comprising a pharmaceutically-acceptable excipient, a dispersibility-enhancing, physiologically-acceptable, water-soluble polypeptide and an active agent to obtain an aerosolizable, dispersible powder composition suitable for administration to a human subject by inhalation therapy, whereby the presence of the polypeptide in the mixture is effective to increase the dispersibility of the spray-dried powder composition over the dispersibility of thespray-drying a homogeneous aqueous mixture comprising a pharmaceutically-acceptable excipient, a dispersibility-enhancing, physiologically-acceptable, water-soluble polypeptide and an active agent to obtain an aerosolizable, dispersible powder composition suitable for administration to a human subject by inhalation therapy, whereby the presence of the polypeptide in the mixture is effective to increase the dispersibility of the spray-dried powder composition over the dispersibility of the composition prepared in the absence of said polypeptide.