Patent ID: 8956572
Filing Date: 2015-02-17
Classification: A61K,B01J,C12N

Abstract:
1. A system for sterilely preparing a lipid-nucleic acid nanoparticle, comprising: a 1 a 2 a mixing unit for mixing the organic lipid solution and the aqueous solution to produce a fluid mixture, wherein the mixing unit comprises a first inlet opening for receiving the organic lipid solution by a 1 a 3 a dilution unit for diluting the fluid mixture with the aqueous buffer to produce a diluted fluid mixture, wherein the dilution unit comprises a 1 a concentrating unit comprising a transflow filter for concentrating and removing the organic solvent from the diluted fluid mixture to produce a filter retentate, wherein the concentrating unit comprises an inlet opening for receiving the diluted fluid mixture by a 5 a vessel for collecting the filter retentate, wherein the vessel comprises an inlet opening for receiving the filter retentate by a 6 wherein the system consists of components that are sterilized and disposable so as to be adapted for single batch usage.