Patent ID: 7078495
Filing Date: 2006-07-18
Classification: A61K,C07K,Y10S

Abstract:
1. A monoclonal antibody to tacrolimus produced by a hybridoma produced by fusion of antibody-producing cells from an antibody-producing mammal immunized with tacrolimus derivatized with a carboxymethyl oxime moiety at carbon atom 22 conjugated to a high molecular weight protein with a suitable fusion partner, that has a binding affinity for tacrolimus of about 3.7×10 9 liters/mole, that cross-reacts with 13-demethyl tacrolimus, and that has less than about 8% cross-reactivity to all of the following tacrolimus metabolites: 15-demethyl tacrolimus; 31-demethyl tacrolimus; 13,31-didemethyl tacrolimus; 15,31-didemethyl tacrolimus; and 12-hydroxy tacrolimus.