Patent ID: 8709790
Filing Date: 2014-04-29
Classification: B01L,B29C,C12M,C12Q,F16K,G01N,Y10T

Abstract:
1. A method of fabricating a microfluidic device comprising: (a) preparing a module comprising an elastomeric monolith having on one face a semi-rigid thermoplastic substrate permanently attached thereto, with ports through the semi-rigid permanently attached substrate accessing a microfluidic network formed in the elastomeric monolith; (b) preparing a holder having on a first surface at least two recessed openings configured to hold fluid or provide fluidic access and having on the opposite surface a cavity, the cavity having openings therein communicating with each of the recessed openings of the holder; and (c) permanently bonding the semi-rigid substrate of the monolith within the cavity of the holder such that the ports of the monolith align with the openings in the cavity of the holder to provide a continuous fluid passage from the openings on the first surface of the holder through the semi-rigid thermoplastic substrate to the microfluidic network formed in the elastomeric monolith.