Patent ID: 6114142
Filing Date: 2000-09-05
Classification: C07K

Abstract:
An isolated nucleic acid molecule selected from the group consisting of: (a) a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:21 and SEQ ID NO:22; (b) a nucleic acid molecule from a filariid nematode selected from the group consisting of Dirofilaria immitis, Onchocerca volvulus and Brugia malayi comprising a homologue of a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 and SEQ ID NO:9, wherein said homologue encodes a protein containing one or more amino acid deletions, substitutions, or insertions, wherein said protein encoded by said homologue comprises at least one epitope comprising at least 5 contiguous amino acids that elicits an immune response against a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:7 and SEQ ID NO:10, wherein said homologue has at least a 15 contiguous nucleotide portion identical in sequence to a 15 contiguous nucleotide portion of a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 and SEQ ID NO:9; and (c) nucleic acid molecules that are fully complementary to any of said nucleic acid molecule of (a) or (b).