Patent ID: 8765946
Filing Date: 2014-07-01
Classification: A61P,C07D

Abstract:
1. A method for inhibiting overexpression of human epidermal growth factor receptor or human epidermal growth factor receptor 2 in cells of a patient in need thereof, the method comprising administering to the patient a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein, X represents N; Y represents CH R R R R R R R A represents a 5-7 membered aromatic ring containing from 0 to 4 heteroatoms selected from N, O, or S; or a polycyclic aromatic group consisting of two or three 5 to 7-membered fused rings; B represents a 5-7 membered aromatic ring containing from 0 to 4 heteroatoms selected from N, O, or S; or a polycyclic aromatic group consisting of two or three 5 to 7-membered fused rings; Ar is phenyl, pyridyl, or substituted phenyl; D represents O, S, NH, or methylene; m and n independently represent an integer from 0 to 4; z is 1, or 2; and t and u independently represent an integer from 0 to 4.