Patent ID: 8784885
Filing Date: 2014-07-22
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition containing a tablet, granule, or fine granule, in which a release of an active ingredient is controlled, wherein the pharmaceutical composition comprises a first component and a second component, each of which has different release properties of the active ingredient relative to the other component, each of the first and second components comprises a core particle containing the active ingredient, which is at least one benzimidazole proton pump inhibitor (PPI) or a salt thereof, the release of the active ingredient in the first component is controlled by a release-controlled coating layer formed on the core particle containing the active ingredient, the release of the active ingredient in the second component is controlled by an enteric coating layer, the first component and the second component individually contain a sufficient amount of the active ingredient to raise a plasma level of the active ingredient in a mammal to whom the pharmaceutical composition is administered to at least 100 ng/ml.