Patent ID: 7906550
Filing Date: 2011-03-15
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R hydrogen-, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl- or -cycloalkenyl-, [(C3-C10)-cycloalkyl or -cycloalkenyl]-(C1-C12)-aliphatic-, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12)aliphatic-, (C3-C10)-heterocyclyl-, (C3-C10)-heterocyclyl-(C1-C12)aliphatic-, (C5-C10)-heteroaryl-, or (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein up to three aliphatic carbon atoms in each of R wherein each of R J is halogen, —OR′, —NO wherein; each R′ is independently selected from the group consisting of: hydrogen-, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl- or -cycloalkenyl-, [(C3-C10)-cycloalkyl or -cycloalkenyl]-(C1-C12)-aliphatic-, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12)aliphatic-, (C3-C10)-heterocyclyl-, (C3-C10)-heterocyclyl-(C1-C12)aliphatic-, (C5-C10)-heteroaryl-, and (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein up to 5 atoms in R′ are optionally and independently substituted with J; wherein two R′ groups bound to the same atom optionally form a 5- to 6-membered aromatic or a 3- to 7-membered saturated or partially unsaturated ring system having up to 3 heteroatoms independently selected from the group consisting of N, NH, O, S, SO, and SO R hydrogen-, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl- or -cycloalkenyl-, [(C3-C10)-cycloalkyl or -cycloalkenyl]-(C1-C12)-aliphatic-, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12)aliphatic-, (C3-C10)-heterocyclyl-, (C3-C10)-heterocyclyl-(C1-C12)aliphatic-, (C5-C10)-heteroaryl-, or (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein any ring is optionally fused to a (C6-C10)aryl, (C5-C10)heteroaryl, (C3-C10)cycloalkyl, or (C3-C10)heterocyclyl; wherein up to 3 aliphatic carbon atoms in each of R wherein each of R R R R R wherein the R wherein said ring optionally contains up to 4 heteroatoms independently selected from the group consisting of N, NH, O, S, SO, and SO wherein any atom is optionally singly or multiply substituted with up to 2 substituents selected independently from J; and wherein said ring is optionally fused to a second ring selected from the group consisting of (C6-C10)aryl, (C5-C10)heteroaryl, (C3-C10)cycloalkyl, and a (C3-C10)heterocyclyl, wherein said second ring has up to 3 substituents selected independently from J; or R R R R (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl- or -cycloalkenyl-, [(C3-C10)-cycloalkyl- or -cycloalkenyl]-(C1-C12)-aliphatic-, (C6-C10)-aryl-(C1-C12)aliphatic-, or (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein up to 3 aliphatic carbon atoms in each of R wherein each of R R hydrogen-, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl-(C1-C12)-aliphatic-, or (C6-C10)-aryl-(C1-C12)-aliphatic-; wherein up to two aliphatic carbon atoms in each of R wherein each of R R R W is: wherein m is 0 or 1; wherein each R hydrogen-, (C1-C12)-aliphatic-, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12)aliphatic-, (C3-C10)-cycloalkyl- or cycloalkenyl-, [(C3-C10)-cycloalkyl- or cycloalkenyl]-(C1-C12)-aliphatic-, (C3-C10)-heterocyclyl-, (C3-C10)-heterocyclyl-(C1-C12)-aliphatic-, (C5-C10)-heteroaryl-, or (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein up to 3 aliphatic carbon atoms in each R wherein R two R wherein each R V is —C(O)—, —C(S)—, —S(O)—, or —S(O) A is hydrogen or —C(R T is oxygen or a bond; R hydrogen-, or (C1-C6)-aliphatic-; wherein up to two aliphatic carbon atoms in each of R R R R hydrogen, (C1-C12)-aliphatic-, (C6-C10)-aryl-(C1-C12)aliphatic-, or (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; wherein up to 3 aliphatic carbon atoms in each R wherein up to 3 aliphatic carbon atoms in each R wherein R wherein any NR R R U is O, N, or a bond; and R wherein the R wherein said ring optionally contains up to 1 additional heteroatom selected from the group consisting of N, NH, O, S, SO, and SO wherein any substitutable atom is optionally singly or multiply substituted with up to 2 substituents selected independently from J; wherein said ring is optionally fused to a second ring selected from the group consisting of (C6-C10)aryl, (C5-C10)heteroaryl, (C3-C10)cycloalkyl, and a (C3-C10)heterocyclyl, wherein said second ring has up to 3 substituents selected independently from J; provided that when R R provided that when R provided that when R and a acceptable carrier, adjuvant or vehicle, wherein said composition is formulated for administration to a patient.