Patent ID: 6320050
Filing Date: 2001-11-20
Classification: A61P,C07C,C07D

Abstract:
A compound selected from the group consisting of an amide of the formula: ##STR139##wherein, the * indicates an asymmetric carbon atom,R.sup.1 and R.sup.2 are independently hydrogen, halo, amino, hydroxyamino, cyano, nitro, lower alkyl, --OR.sup.5, ##STR140##perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or sulfonamido, R.sup.3 is cycloalkyl having from 3 to 7 carbon atoms;R.sup.4 is an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano,--(CH.sub.2).sub.n -OR.sup.6,##STR141##--(CH.sub.2).sub.n -NHR.sup.6n is 0, 1, 2, 3 or 4;R.sup.5 is hydrogen, lower alkyl, or perfluoro-lower alkyl and R.sup.6, R.sup.7 and R.sup.8 are independently hydrogen or lower alkyl;and a pharmaceutically acceptable salt thereof.