Patent ID: 8673552
Filing Date: 2014-03-18
Classification: C07K,C12N,C12Q,G01N,G16B

Abstract:
1. A method for identifying a candidate therapeutic for a disease caused by a virus having class II E protein, comprising contacting the virus having a dengue virus class II E protein with a compound, assaying viral infectivity, wherein the inhibition of viral infectivity of said virus indicates a candidate therapeutic, wherein the dengue virus class II E protein consists of an amino acid sequence at least 20 amino acids but not greater than 394 amino acids in length having at least 85% identity along the length to the amino acid sequence of SEQ ID NO: 1 or 2, wherein amino acid residue 101 is Trp, amino acid residue 107 is Leu and amino acid residue 108 is Phe when numbered in accordance with SEQ ID NO: 1 or 2.