Patent ID: 6780428
Filing Date: 2004-08-24
Classification: A61K,B01J

Abstract:
A unimolecular polymeric micelle comprising an ionizable inner core and a hydrophilic outer shell wherein said ionizable inner core includes ionizable repeating units alone or in combination with non-ionic hydrophobic repeating units and wherein said ionizable repeating units include at least one compound selected from the group consisting of alkylacrylic acid derivatives, acrylic acid derivatives (aminoalkyl) acrylate derivatives, and (aminoalkyl) alkylacrylate derivatives and wherein said non-ionic hydrophobic repeating units include at least one compound selected from the group consisting of acrylate derivatives, acrylamide derivatives, alkylacrylate derivatives, alkylacrylamide derivatives, arylacrylate derivatives and arylacrylamide derivatives; andwherein said hydrophilic outer shell is non-ionic and originates from functionalized and hydrophilic polymers, and includes at least one hydrophilic compound selected from the group consisting of vinyl monomers a vinyl oligomers and vinyl polymers.