Patent ID: 6238873
Filing Date: 2001-05-29
Classification: C07K,G01N

Abstract:
A method for identifying an agonist or antagonist of the KIAA0001 polypeptide set forth in SEQ ID NO:2, said method comprising the steps of:(a) contacting a cell expressing on the surface thereof the polypeptide, said polypeptide being associated with a second component capable of providing a detectable signal in response to the binding of a compound to said polypeptide, with a compound to be screened under conditions to permit binding to the polypeptide in the presence of a labeled or unlabeled UDP sugar selected from the group consisting of: UDP-glucose, UDP-galactose, UDP-glucoronic acid, and UDP-N-acetyl glucosamine; and(b) determining whether the compound binds to and activates or inhibits the polypeptide by measuring the level of a signal generated from the interaction of the compound with the polypeptide, thereby identifying an agonist or antagonist of the polypeptide set forth in SEQ ID NO:2.