Patent ID: 7629374
Filing Date: 2009-12-08
Classification: A61K,A61P,C07D

Abstract:
1. A method of inhibiting the phosphorylation of the tau protein in a patient, wherein a disease treatable by said inhibition is obesity or stroke, comprising administering to said patient an effective amount of a compound of formula (I): wherein R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, CSNR1R2, COOR1, SO R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH R1, R2, R8, R9, R10 and R11 are, independently of one another, a hydrogen, (1-6C)alkyl, aryl, alkenyl, alkynyl, heteroaryl, themselves optionally being substituted by 1 or more substituents chosen from halogen, (1-6C)alkyl, (1-6C)alkoxy, CN, NO R1 and R2 or R8 and R9 or R10 and R11 can form a 5- or 6-membered ring which may or may not have a heteroatom selected from O, S or N; and, when R3 is a 6-membered nitrogenous heteroaryl or a thiazolyl or an imidazolyl or an oxazolyl, then at least one of the R5 and R6 groups is an aryl which is optionally substituted by 1 or more substituents selected from halogen, CN, NO a racemate, an enantiomer or a diastereoisomer or a mixture thereof, or a tautomer thereof or a pharmaceutically acceptable salt thereof.