Patent ID: 6541475
Filing Date: 2003-04-01
Classification: A61P,C07C,C07D

Abstract:
(amended) A compound of the formula I: wherein:Q1 is selected from the group consisting of(a) a phenyl radical according to formula II wherein R1, R2, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1 -C6 trifluoroalkoxy and trifluoromethyl; R3 is selected from the group consisting of halogen, C1 -C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl; (b) an aromatic radical selected from the group consisting of 1-naphthyl, 2- naphthyl and 9-anthryl; and (c) an aromatic radical according to formula III whereinn1 is 1 or 2, Y1 and Y2 are independently selected from the group consisting of hydrogen and halogen and X1 is selected from the group consisting of oxygen, nitrogen, sulfur and Q2 is selected from the group consisting of(d) a phenyl radical according to formula II whereinR1, R2, R1 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl; R3 is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl; (e) an aromatic radical selected from the group consisting of 1-naphthyl, 2- naphthyl and 9-anthryl; (f) an aromatic radical according to formula IV whereinn2 is 1 or 2, Y3 and Y4 are independently selected from the group consisting of hydrogen, halogen, and nitro, and X2, X3 and X4 are independently selected from the group consisting of carbon, oxygen, nitrogen, sulfur and provided that not all of X2, X3 and X4 may be carbon; and(g) 1-piperazinyl; provided that at least one of Q1 or Q2 is other than a phenyl radical according to formula II; or a pharmaceutically acceptable salt thereof.