Patent ID: 7749729
Filing Date: 2010-07-06
Classification: G01N,Y10T

Abstract:
1. A method for assessing the presence of cardiovascular disease wherein abnormal levels of at least one high-density lipoprotein (“HDL”) oxidation product is associated with the presence of cardiovascular disease comprising the steps of: A) obtaining a biological sample from a subject; B) measuring the amount of an HDL tyrosine oxidation product in the biological sample, wherein the HDL tyrosine oxidation product is at least one of 3-nitrotyrosine, 3-chlorotyrosine or o′,o′-dityrosine; C) comparing the amount of the HDL tyrosine oxidation product in the biological sample with a range of predetermined values indicative of a healthy population, wherein an increase in the oxidized HDL tyrosine product as compared to a predetermined normal reference range, is indicative of the presence of cardiovascular disease in the subject.