Patent ID: 7553842
Filing Date: 2009-06-30
Classification: A61K,A61P,C07D

Abstract:
1. A compound including resolved enantiomers, diastereomers; and pharmaceutically acceptable salts thereof, said compound having the Formula I: wherein: X is alkyl, alkenyl, or alkynyl, wherein said alkyl, alkenyl and alkynyl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, aryl, COOR A is O; or A represents a carbon atom and an oxygen atom each bonded to carbon 32 of Formula I and which together complete a saturated or partially unsaturated five, six or seven membered spirocyclic lactone ring; Y is H or R or Y is  wherein said Y groups are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, OR L is alkylene, Z  wherein the asterisk indicates the point of attachment to Y; or Y is R  wherein said Y groups are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, OR L is absent, alkylene, Z  wherein the asterisk indicates the point of attachment to Y; Z is C Ar is arylene optionally substituted with one or more groups independently selected from F, Cl, Br and I; D is CH E is O, S, NR m is 0 or 1; j is 1, 2, 3, 4, or 5; R R R R