Patent ID: 7935815
Filing Date: 2011-05-03
Classification: A61P,C07D

Abstract:
1. A compound represented by formula (I-1), (I-2) or (1-3): or a pharmacologically acceptable salt thereof, wherein X Het represents a group which may be substituted with 1 to 3 substituents selected from Substituent Group A1 and is represented by the following formula: wherein n Substituent Group A1: (1) a hydrogen atom, (2) a halogen atom, (3) a hydroxyl group, (4) a cyano group, (5) a nitro group, (6) a C3-8 cycloalkyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (7) a C2-6 alkenyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (8) a C2-6 alkynyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (9) a C3-8 cycloalkoxy group, (10) a C3-8 cycloalkylthio group, (11) a formyl group, (12) a C1-6 alkylcarbonyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (13) a C1-6 alkylthio group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (14) a C1-6 alkylsulfinyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (15) a C1-6 alkylsulfonyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (16) a hydroxyimino group, (17) a C1-6 alkoxyimino group, (18) a C1-6 alkyl group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (19) a C1-6 alkoxy group which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (20) an amino group which may be substituted with 1 or 2 substituents selected from Substituent Group A2, (21) a carbamoyl group which may be substituted with 1 or 2 substituents selected from Substituent Group A2, (22) A* (wherein A* represents an aromatic hydrocarbon ring selected from a phenyl group, an indenyl group, a naphthyl group, an azulenyl group, a heptalenyl group, a fluorenyl group, a phenalenyl group, a phenanthrenyl group and an anthracenyl group, an aromatic heterocycle selected from a pyrrolyl group, a pyridyl group, a pyridazinyl group, a pyrimidinyl group, a pyrazinyl group, a pyrazolinyl group, an imidazolyl group, an indolyl group, an isoindolyl group, an indolizinyl group, a purinyl group, an indazolyl group, a quinolyl group, an isoquinolyl group, a quinolizinyl group, a phthalazinyl group, a naphthyridinyl group, a quinoxalinyl group, a quinazolinyl group, a cinnolinyl group, a pteridinyl group, an imidazotriazinyl group, a pyrazinopyridazinyl group, an acridinyl group, a phenanthridinyl group, a carbazolyl group, a perimidinyl group, a phenanthrolinyl group, a thienyl group and a benzothienyl group, a furyl group, a pyranyl group, a cyclopentapyranyl group, a benzofuranyl group and an isobenzofuranyl group, a thiazolyl group, an isothiazolyl group, a benzothiazolinyl group, a benzothiadiazolyl group, a phenothiazinyl group, an isoxazolyl group, a furazanyl group, a phenoxazinyl group, a pyrazoloxazolyl group, an imidazothiazolyl group, a thienofuryl group, a furopyrrolyl group and a pyridooxazinyl group), which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (23) a 6- to 14-membered non-aromatic hydrocarbon ring which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (24) a 5- to 14-membered non-aromatic heterocycle, which may be substituted with 1 to 3 substituents selected from Substituent Group A2, (25) a C2-6 alkenyloxy group, (26) a C2-6 alkynyloxy group, (27) a C3-8 cycloalkylsulfinyl group, (28) a C3-8 cycloalkylsulfonyl group, (29) —X-A* (wherein X represents an imino group, —O— or —S— and A* is as defined above, wherein A* may be substituted with 1 to 3 substituents selected from Substituent Group A2), (30) —CO-A* (wherein A* is as defined above, which may be substituted with 1 to 3 substituents selected from Substituent Group A2), (31) ═CH-A* (wherein A* is as defined above, which may be substituted with 1 to 3 substituents selected from Substituent Group A2), (32) a carboxyl group, (33) a C1-6 alkoxycarbonyl group and (34) an azido group; Substituent Group A2: (1) a hydrogen atom, (2) a halogen atom, (3) a hydroxyl group, (4) a cyano group, (5) a nitro group, (6) a C3-8 cycloalkyl group, (7) a C2-6 alkenyl group, (8) a C2-6 alkynyl group, (9) a C3-8 cycloalkoxy group, (10) a C3-8 cycloalkylthio group, (11) a formyl group, (12) a C1-6 alkylcarbonyl group, (13) a C1-6 alkylthio group, (14) a C1-6 alkylsulfinyl group, (15) a C1-6 alkylsulfonyl group, (16) a hydroxyimino group, (17) a C1-6 alkoxyimino group, (18) a C1-6 alkyl group (wherein the C1-6 alkyl group may be substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a hydroxyl group, a C1-6 alkoxy group, a phenyl group which may be substituted with 1 to 3 halogen atoms and a pyridinyl group which may be substituted with 1 to 3 halogen atoms), (19) a C1-6 alkoxy group (wherein the C1-6 alkoxy group may be substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a hydroxyl group, a C1-6 alkoxy group, a phenyl group which may be substituted with 1 to 3 halogen atoms and a pyridinyl group which may be substituted with 1 to 3 halogen atoms), (20) an amino group which may be substituted with 1 or 2 C1-6 alkyl groups or C1-6 alkylcarbonyl groups, (21) a carbamoyl group which may be substituted with 1 or 2 C1-6 alkyl groups, (22) A* (wherein A* is as defined above), (23) a 6- to 14-membered non-aromatic hydrocarbon ring, (24) a 5- to 14-membered non-aromatic heterocycle, (25) a C2-6 alkenyloxy group, (26) a C2-6 alkynyloxy group, (27) a C3-8 cycloalkylsulfinyl group, (28) a C3-8 cycloalkylsulfonyl group, (29) —X-A* (wherein X represents an imino group, —O—, —S— or —SO2- and A* is as defined above, wherein A* may be substituted with 1 to 3 halogen atoms), (30) —CO-A* (wherein A* is as defined above, which may be substituted with 1 to 3 halogen atoms) and (31) ═CH-A* (wherein A* is as defined above, which may be substituted with 1 to 3 halogen atoms).