Patent ID: 6110963
Filing Date: 2000-08-29
Classification: C07C,C07D

Abstract:
A compound of formula I having the structure ##STR11## wherein A is C;B is O, or S;E is ##STR12## or --X--D; D is ##STR13## or alkyl of 1-12 carbon atoms; X is CO, CH(OH), CH.sub.2, or --CH--S-2-benzothiazole;Y is hydrogen, alkyl of 1-6 carbon atoms, or halogen;Z is O, S, or N;R is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, or trifluoromethyl;R.sup.1 is alkyl of 1-12 carbon atoms, aryl of 6-10 carbon atoms, aralkyl of 7-15 carbon atoms, halogen, Het-alkyl wherein the alkyl moiety contains 1-6 carbon atoms, or aryl mono-, di- or tri-substituted with a substituent selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, trifluoromethyl, and alkoxy of 1-6 carbon atoms;Het is ##STR14## G is O, S, or N; R.sup.2 is hydrogen, halogen, alkyl of 1-6 carbon atoms, or --OR.sup.5R.sup.3 and R.sup.4 are each, independently, hydrogen, halogen, alkyl of 1-8 carbon atoms, aryl of 6-12 carbon atoms, nitro, amino, alkylsulfoamide, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, heterocycle of 5 to 7 ring atom containing from 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur, or aryl of 6-10 carbon atoms mono-, di- or tri-substituted with a substituent selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, trifluoromethyl, alkoxy of 1-6 carbon atoms;R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, --CH(R.sup.7)R.sup.8, --C(CH.sub.2).sub.n CO.sub.2 R.sup.9, --C(CH.sub.3).sub.2 CO.sub.2 R.sup.9, CH(R.sup.7)(CH.sub.2).sub.n CO.sub.2 R.sup.9, or --CH(R.sup.7)C.sub.6 H.sub.4 CO.sub.2 R.sup.9 ;R.sup.6 is alkylene of 1-3 carbon atoms;R.sup.7 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, phthalic acid, or Q-alkyl wherein the alkyl moiety contains 1-6 carbon atoms;Q is ##STR15## R.sup.8 is --CO.sub.2 R.sup.11, --CONHR.sup.11, tetrazole, or --PO.sub.3 R.sup.11 ;R.sup.9 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, or aralkyl of 7-15 carbon atoms;W is O, N, or S;R.sup.11 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, or aralkyl of 7-15 carbon atoms;n=1-6;or a pharmaceutically acceptable salt thereof with the proviso that when E is --X--D, D is not ##STR16## further provided that when E is X-- D, R1 cannot be phenyl substituted with alkoxy.