Patent ID: 7384929
Filing Date: 2008-06-10
Classification: A61P,C07D

Abstract:
1. A compound of Formula 1: wherein: R is H or C m is 1, 2, 3, or 4; n is 0, 1, or 2; p is 0, 1, 2, or 3; q is 0, 1, 2, 3, or 4; and j is 0, 1, 2, or 3; and the values of m, n, p and q are selected such that the depicted azaspiro ring contains 6, 7, 8, 9, 10 or 11 members; and when m is 1, n is not 0; and m and n combine such that the depicted aza-containing ring is 4-, 5-, or 6-membered; each Z is, individually, selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, and substituted arylalkyl; the dashed line represents an optional double bond; Cy is pyridinyl or substituted pyridinyl; wherein the term substituted refers to one or more of a group consisting of alkyl, alkenyl, heterocyclyl, cycloalkyl, aryl, alkylaryl, arylalkyl, halogen, —OR′, —NR′R″, —CF each R′ and R″ individually is hydrogen. C R′ and R″ can combine to form a 3- to 7-membered saturated or unsaturated ring; or a pharmaceutically acceptable salt thereof wherein any open valences are filled by hydrogen.