Patent ID: 8912230
Filing Date: 2014-12-16
Classification: A61K,A61P

Abstract:
1. A method for treating the senescence of vascular endothelial cells induced by repeated inflammatory episodes in an individual in need thereof, which comprises administering to an individual having senescence of vascular endothelial cells induced by repeated inflammatory episodes at least one plant-origin compound of terpene type, wherein said plant-origin terpene compound is selected from the group consisting of geranyl acetate, geraniol, isomenthone and limonene and said plant-origin compound of terpene type reverses the senescent phenotype of vascular endothelial cells and wherein said individual is selected by determining in a biological sample of an individual comprising vascular endothelial cells the expression level of the adhesion molecule ICAM-1 and wherein a patient is selected when ICAM-1 is overexpressed in vascular endothelial cells.