Patent ID: 7763580
Filing Date: 2010-07-27
Classification: A61K,C07K

Abstract:
1. A method for reducing excess accumulation of extracellular matrix associated with TGFβ overproduction and/or activity, in a tissue and/or organ, or at a dermal wound site, by administering a combination of agents that decrease TGFβ by different biochemical pathways, comprising a first agent that binds to and inhibits TGFβ, and a different, second agent that inhibits TGFβ by inhibiting a different biochemical pathway than said first agent, that results in decreased TGFβ activity, in an amount sufficient to inhibit TGFβ overproduction and/or activity, the administration of the combination of said first and second agents resulting in greater reduction in extracellular matrix, than the total reduction of extracellular matrix achieved when each agent is administered separately, whereby the accumulation of extracellular matrix in said tissue and/or organ or wound site is reduced from the level existing at the time of administration of the agents.