Patent ID: 6127546
Filing Date: 2000-10-03
Classification: C07D

Abstract:
A process for the preparation of an oxazoline compound represented by the following formula (2), comprising the steps of:subjecting a compound employed as a starting material and represented by the following formula (4) to cyclization using a palladium compound as a catalyst to produce a compound represented by the following formula (3);oxidizing the compound of the formula (3) using a first oxidizing agent and a solution of 9-borabicyclo[3.3.1]nonane in a tetrahydrofuran solvent; andfurther oxidizing the compound of the formula (3) using a second oxidizing agent and a mixed solvent of acetonitrile/carbon tetrachloride/water to obtain the oxazoline compound represented by the following formula (2): ##STR8## where R is methyl, isopropyl, isobutyl, sec-butyl, thiomethyl, cyclohexyl, cyclohexylmethyl, phenyl, p-hydroxyphenyl, phenylmethyl, or p-hydroxyphenylmethyl, Ph is a phenyl group, X represents leaving group, and is acetate, benzoate, carbonate, or halide, and Bz is a benzoyl group.