Patent ID: 6399071
Filing Date: 2002-06-04
Classification: A61K,A61P,B01J,C07K

Abstract:
A method for removing xenoantibodies from the human body fluid of a xenograft recipient, which method comprises extracorporally contacting said body fluid with a composition comprising a polyamide conjugate comprising a human xenoantigenic group bound to a linear polyamide backbone, wherein the polyamide backbone comprises at least one structural element of formula I wherein A is a trivalent bridging group; R1 is a direct bond or C1-C6alkylene; X1 is â€”C(O)Oâ€”, â€”C(O)NRâ€”, â€”NRâ€”, â€”Sâ€”, or â€”Oâ€”; R2 is a direct bond or a bivalent bridging group; X2 is a direct bond or â€”Oâ€” or â€”NRâ€”; wherein R is hydrogen, OH, C1-C12alkyl, C2-C12alkenyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, C2-C7heterocycloalkyl, C2-C11heterocycloalkenyl, C6 C10aryl, C5-C9heteroaryl, C7-C16aralkyl, C8-C16aralkenyl with C2-C6or alkenylene and C6 or C10aryl, or di-C6 or C10aryl-C1-6-alkyl; and Y is a direct bond or a bivalent bridging group; with the proviso that X1 is not â€”NRâ€”, â€”Sâ€” or â€”Oâ€” when R1 is a direct bond; and reintroducing the body fluid into said xenograft recipient; or for inducing tolerance or anergy towards xenoantigenic epitopes or to specifically target B cells with xenoantigen receptors in a human xenograft recipient in need of such treatment, which method comprises administering into said xenograft recipient prior to and/or after transplantation of the xenograft an effective amount of a composition comprising said polyamide conjugate.