Patent ID: 7842664
Filing Date: 2010-11-30
Classification: A61K,A61P,C07K

Abstract:
1. A reconstituted surfactant, consisting of: a) a phospholipid vehicle; b) an artificial peptide analog of natural surfactant protein SP-C; and c) an artificial peptide analog of natural surfactant protein SP-B, wherein said vehicle is a mixture consisting of: (i) dipalmitoyl phophatidylcholine (DPPC) and (ii) a palmitoyl oleyl phospholipid selected from the group consisting of 1 palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and a mixture of 1 palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol and 1 palmitoyl-2-oleoyl-sn-3-glycero-3-phosphocholine (POPC), in a weight ratio ranging from 80:20 to 60:40, and wherein said artificial peptide analog of natural surfactant protein SP-C has the formula (II): wherein Ω is a residue selected from the group consisting of M, I, L and nL.