Patent ID: 6566393
Filing Date: 2003-05-20
Classification: C07D

Abstract:
A compound according to Formula I: wherein:X is a linking group selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”NHâ€”, â€”COâ€”, â€”CH&boxH;Nâ€”, or CH2NHâ€”; R1 is a covalent linkage between X and Y, or is loweralkyl, loweralkenyl, or phenyl, and when phenyl is unsubstituted or is substituted from one to four times with loweralkyl, hydroxy, alkoxyl, alkylogen, or alkylamino, alkyoxycarbonyl, amino, halogen, nitro, or nitrile; Y is â€”NHCOâ€” or â€”CONHâ€”; Z is â€”CHR2â€”(CH2)nR3, where n is 0 to 2 and R2 is â€”COOH, â€”NH2, â€”COOR31 where R31 is loweralkyl, COOCH2Ph, or â€”NHCOOCH2Ph; R3 is a lower alkyl, loweralkenyl or aryl, which may be unsubstituted or substituted one or more times with loweralkyl, loweralkenyl, or hydroxy, alkoxyl, alkylamino, thioalkyl, hydroxycarbonyl, guanidino, or amido; and D is selected from the group consisting of â€”CH2OC(&boxH;O)â€”; â€”CH2OC(&boxH;CH2)â€”; â€”CH2CH2C(&boxH;O)â€”; â€”CH2OC(&boxH;S)â€”; â€”CH2OCH2â€”; â€”CH2OCH(â€”OH)â€”; â€”CH2OCH(OCH3)â€”; â€”CH2CH2C(â€”NR12)â€” where R12 is loweralkyl; â€”C(&boxH;O)CH2C(O)â€”; â€”CH2OS(&boxH;O)(&boxH;O)OCH2â€”; and â€”CH2OS(&boxH;O)OCH2â€”; or a pharmaceutically acceptable salt thereof.