Patent ID: 8071781
Filing Date: 2011-12-06
Classification: C07D

Abstract:
1. A process for preparing rabeprazole sodium comprising the steps of: (a) contacting rabeprazole sodium compound with a solvent system to thereby obtain a clear solution under a first temperature ranging from 25 to 50, wherein said solvent system is a mixture comprising a ketone solvent and a cyclic hydrocarbon solvent, a mixture comprising a ketone solvent and an ether solvent, or a mixture comprising a heterocyclic organic solvent and a cyclic hydrocarbon solvent, and wherein: (b) stirring said clear solution of step (a) under a second temperature for more than 3 hours to obtain a solution containing resultant separated solid, wherein said second temperature ranges from 25 to 50; (c) filtering said solution containing resultant separated solid obtained from step (b) to obtain a wet solid; and (d) drying said wet solid to obtain an amorphous rabeprazole sodium compound.