Patent ID: 6812364
Filing Date: 2004-11-02
Classification: A61P,C07C

Abstract:
A compound of formula III or a pharmaceutically acceptable equivalent of said compound, wherein:X and Y are independently â€”CR5R6â€”, â€”Oâ€”, â€”Sâ€” or â€”NRâ€”, provided that at least one of X and Y is/are â€”CR5R6â€”; A1, A2, A3, A4 and A5 are independently hydrogen, C1-C9 alkyl, C2-C9 alkenyl, C2-C9 alkynyl, aryl, heteroaryl, carbocycle, heterocycle, C1-C9 alkoxy, C2-C9 alkenyloxy, phenoxy, benzyloxy, hydroxy, halo, cyano, isocyano, â€”COOR7, â€”COR7, â€”NR7R8, â€”SR7, â€”SOR7, â€”SO2R7, â€”SO2(OR7), â€”(C&boxH;O)NR7R8, â€”(C&boxH;O)NR7(CH2)nCOOH, â€”NR7(C&boxH;O)R8 or â€”(CH2)nCOOH, or any adjacent two of A1, A2, A3, A4 and A5 form with the benzene ring a fused ring that is saturated or unsaturated, aromatic or non-aromatic, and carbocyclic or heterocyclic, said heterocyclic ring containing 1 or 2 oxygen, nitrogen and/or sulfur heteroatom(s); n is 1-3; R, R1, R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen, C1-C9 alkyl, C2-C9 alkenyl, C2-C9 alkynyl, aryl, heteroaryl, carbocycle or heterocycle; and said alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocycle, heterocycle, alkoxy, alkenyloxy, phenoxy, benzyloxy, and fused ring are independently unsubstituted or substituted with one or more substituent(s); provided that if A1, A2 and A3 are each hydrogen, and A4 and A5 are each â€”COOH, then A4 is ortho to A5 and provided that if Y is â€”CR5R6â€”, then at least one of A1, A2, A3, A4 and A5 is/are independently phenoxy, benzyloxy, aryl, heteroaryl, carbocycle or heterocycle that is substituted with one or more substituent(s). and provided that at least one of A1, A2, A3, A4 and A5 are not hydrogen.