Patent ID: 6657104
Filing Date: 2003-12-02
Classification: A01K,A61K,A61P,C12N,G01N,Y10S

Abstract:
A transgenic mouse having a genome comprising a transgene which comprises:a) a coding region which encodes calcineurin, calcium calmodulin dependent kinase IV (CaMKIV), or a functional fragment of calcineurin or CaMKIV; and b) a transcriptional control element (TRE) operably linked to said coding region, wherein said TRE comprises a promoter preferentially active in cardiomyocytes, wherein the expression of calcineurin, CaMKIV, or a functional fragment of calcineurin or CaMKIV in said transgenic mouse results in an increased probability of spontaneously developing cardiac hypertrophy when compared to a non-transgenic littermate.