Patent ID: 7585888
Filing Date: 2009-09-08
Classification: A61P,C07D

Abstract:
1. A method of treating a hyper-proliferative disorder comprising administering to a patient in need thereof an effective amount of a compound of Formula I: wherein X is selected from O and S; R 1 is selected from H, (C 1 -C 6 )alkyl, C(O)(C 1 -C 6 )alkyl, and benzoyl; R 2 is selected from phenyl and naphthyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from a heterocycle selected from a six membered heterocycle, a five membered heterocycle and a fused bicyclic heterocycle, each heterocycle being optionally substituted with 1, 2 or 3 substituents each independently selected from R A is in each instance independently H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, NR B R B , or (C (C R B is in each instance independently H, (C 3 -C 6 )cycloalkyl, and (C and where R and where R and with the proviso that when R R 3 is selected from H, OH, CN, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, halo, halo(C 1 -C 3 )alkyl, and halo(C R 4 is selected from piperonyl, Y where phenyl and naphthyl each optionally substituted with 1, 2, or 3 substituents each independently selected from R 5 and R 6 are each independently selected from H, OH, CN, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, halo, halo(C or a pharmaceutically acceptable salt or ester thereof.