Patent ID: 6207677
Filing Date: 2001-03-27
Classification: A61P,C07D

Abstract:
A method for treating anxiety, epilepsy, convulsion, movement disorder, or amnesia by action on sigma receptors, comprising adminisering to a patient in need thereof a therapeutically effective amount of a sigma receptor binding compound of formula I: ##STR21##wherein R.sup.1 is a group having the Formula II: ##STR22##wherein X is CHR.sup.10, O, S, SO, SO, or NR.sup.10, R.sup.10 being hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl or cycloalkenylalkyl, acyl, aminoalkyl, mono- or dialkylaminoalkyl, sulfonyl or arylalkyl or phenyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and cyano, or R.sup.10 is 2-thienyl, 3-thienyl, 2-furanyl, 3-furanyl, 2-thiazolyl, 2-oxazolyl, 2-imidazolyl, 2-pyridyl, 3-pyridyl, or 4-pyridyl;one or two of the dashed lines may be a bond;when he dotted line emanating from Y indicates a bond, Y is N or CH; orwhen said dotted line indicates no bond, Y is CH.sub.2, NH, C.dbd.O or C.dbd.S;R.sup.a -R.sup.d is independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, lower alkylsulphonyl, lower alkylamino, lower dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio;U is CH.sub.2, O, or S; orwhen one of the dotted lines emanating from U indicates a bond, U is CH; the bond between Q.sup.1 or Q.sup.2, respectively, and U may also be a triple bond and in such case U is C;Q.sup.1 is elected from a bond, alkylene or alkenylene and Q.sup.2 is alkylene having at least two C-atoms, alkenylene or a group Q.sup.2 'D wherein Q.sup.2 is as defined for Q.sup.2 and D is CR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are independently selected from the substituents define below for R.sup.4 -R.sup.7, or a cycloalkylene group, Q.sup.1 and Q.sup.2 having together from 2 to 20 carbon atoms and being optionally substituted with one or more hydroxy groups, any such hydroxy group being optionally esterified with an aliphatic carboxylic acid having from two to twenty four carbon atoms inclusive; andR.sup.2 and R.sup.3 are independently hydrogen, lower alkyl or they may be linked together by forming an ethylene or propylene bridge;R.sup.4 to R.sup.7 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, lower alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio; andZ.sup.1 is a group as defined for R.sup.4 -R.sup.7, Z.sup.2 is hydrogen and Z.sup.3 is a bond;or an acid addition salt or a prodrug thereof.