Patent ID: 6448242
Filing Date: 2002-09-10
Classification: A61P,C07C,C07D

Abstract:
A compound having the formula (1): wherein: A is indenyl, phenyl, naphthyl, dihydronaphthyl, indolyl, isoindolyl, pyridyl, quinolyl or isoquinolyl, each of which is optionally substituted by 1 to 3 substituents selected from the group consisting of hydroxyl; halogen; lower alkyl which is optionally substituted by 1 to 3 halogen; lower alkoxy; amino; monoalkylamino; dialkylamino; and lower alkylthio; X is a single bond; lower alkylene which is optionally substituted; divalent residue of an alicyclic compound which is optionally substituted; aromatic compound which is optionally substituted; heterocyclic compound which is optionally substituted; imino which is optionally substituted; or a sulfur atom or an oxygen atom; Y is a single bond, lower alkylene, imino or lower alkylimino; Z is a group of the formula â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”(CH&boxH;CH)2â€”, â€”Câ‰¡Câ€”CH&boxH;CHâ€” or â€”CH&boxH;CHâ€”Câ‰¡Câ€”, or a divalent residue of benzene, pyridine, pyrimidine or pyrazine which is each optionally substituted; B is a nitrogen atom; and m and n are the same or different from each other and are each independently an integer of 1 to 4; or a salt or solvate thereof.