Patent ID: 8946456
Filing Date: 2015-02-03
Classification: C07C,C07D

Abstract:
1. Process for the preparation of 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol of formula (I), comprising: a. silylating 4-hydroxymethylphenol of formula (A) with a silylating agent to obtain a bis-silylated compound of formula (B) wherein PG is a silylated protective group; b. selectively deprotecting the phenolic hydroxyl of the bis-silylated compound of formula (B) to obtain a mono-silylated compound of formula (C) c. reacting the compound of formula (C) with trans-cinnamaldehyde and a cyclic secondary amine of formula (F) wherein R W is (CH2) to obtain a compound of formula (D) d. deprotecting the compound of formula (D), to obtain a compound of formula (E) and e. hydrolyzing the compound of formula (E) to provide the compound of formula (I).