Patent ID: 9067981
Filing Date: 2015-06-30
Classification: A61K,C07K

Abstract:
1. An isolated antibody that binds to an epitope within residues 3-7 of Aβ, wherein CDRs L1, L2 and L3 are CDRs L1, L2 and L3 of an antibody other than 12A11 that binds to an epitope within residues 3-7 of Aβ, and CDRs H1 and H2 are CDRs H1 and H2 of the antibody other than 12A11 and CDRs L1, L2, L3, H1 and H2 of the isolated antibody differ from corresponding CDRs of 12A11 and CDR H3 is either CDR H3 of antibody 12A11 or CDR H3 of the antibody other than 12A11 modified by absence of residues X2, X3 and X4 of SEQ ID NO:28, wherein CDRs L1, L2 and L3 are CDRs L1, L2 and L3 of antibody PFA1, and CDRs H1 and H2 are CDRs H1 and H2 of antibody PFA1 and CDR H3 is CDR H3 of antibody 12A11.