Patent ID: 6143328
Filing Date: 2000-11-07
Classification: A61K

Abstract:
An oral sustained release pharmaceutical formulation comprising multiparticulates including morphine or a pharmaceutically acceptable salt thereof dispersed in a matrix of a natural or synthetic wax or oil with a melting point of from about 35 degrees C. to about 100 degrees C., such that the multiparticulates provide a time to peak plasma level of morphine in about 1.0 to about 6.0 hours after administration, and when administered in an effective amount, provide morphine plasma levels which are effective for 24 hourly dosing, characterized by a width of the plasma profile at 50% Cmax (W.sub.50) for the morphine-6-glucoronide metabolite of morphine of between 4 and 12 hours, said multparticulates being prepared by mixing together said morphine or salt thereof and said natural or synthetic wax or oil at a rate and energy input sufficient to cause said natural or synthetic wax or oil to melt or soften whereby it forms said multiparticulates containing said morphine or salt thereof.