Patent ID: 6653283
Filing Date: 2003-11-25
Classification: A61K,A61P,C07K

Abstract:
A method of inhibiting angiogenesis in a subject, having a disease or disorder causing angiogenesis comprising administering to the subject an amount of a peptide that is effective to inhibit angiogenesis, in which the peptide is:(a) an inhibitor of bFGF-stimulated bovine endothelial cell proliferation having an IC50 of 10 &mgr;M or less; (b) selected from the group consisting of fast-twitch troponin subunit C (SEQ ID NO:1), fast-twitch troponin subunit I (SEQ ID NO:2), and fast-twitch troponin subunit T (SEQ ID NO:3), and cartilage troponin I (SEQ ID NO:17).