Patent ID: 6235753
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I): ##STR43##wherein:R is hydroxy, hydrogen, alkyl, alkenyl, alkynyl or aryl;R.sup.1 is arylmethyl or heterocyclylmethyl;R.sup.2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl; andR.sup.3 is hydrogen, alkyl, alkenyl, alkynyl or aryl;with the proviso that;if R.sup.1 is phenylmethyl or naphthylmethyl, wherein the phenyl or naphthyl group is unsubstituted or substituted by up to five substituents selected from the group consisting of halogen, (C.sub.1-6)alkyl, aryl(C.sub.1-6)alkyl, (C.sub.1-6)alkoxy, (C.sub.1-6)alkoxy(C.sub.1-6)alkyl, halo(C.sub.1-6)alkyl, hydroxy, nitro, amino, mono- and di-N-(C.sub.1-6)alkylamino, acylamino, acyloxy, carboxy, carboxy salts, carboxy esters, carbamoyl, mono- and di-N-(C.sub.1-6)alkylcarbamoyl, (C.sub.1-6)alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, sulphonylamino, aminosulphonyl, (C.sub.1-6)alkylthio, (C.sub.1-6)alkyl sulphinyl (C.sub.1-6)alkylsulphonyl, heterocyclyl, heterocyclyl (C.sub.1-6)alkyl, and a (C.sub.3-5)alkylene chain linking two adjacent ring carbon atoms to form a carbocyclic ring; then R is hydroxy.