Patent ID: 6329425
Filing Date: 2001-12-11
Classification: A61K,A61P,C07C,C07F,C07K,C12N,C12P,C12R,G01N,Y02A

Abstract:
A method for treating or preventing a disease or condition associated with columnar epithelial inflammation in a subject comprising administering to a subject an effective anti-inflammatory amount of a pharmaceutical composition comprising a lipoxin A.sub.4 analog, said lipoxin analog having one or more substitutions at C-13/C-14, C-15, C-16, C-19, or C-20, wherein C-15 or C-16, each independently, are substituted with a hydroxyl, a methyl, a fluoromethyl, or a fluoro group, wherein C-16 is substitued with a phenyl, a halo-substituted phenyl or an alkoxide group, wherein C-19 or C-20, each independently, are substituted with a fluromethyl, a phenyl, or a fluoro group, wherein C-13/C-14 can form a triple bond, and a pharmaceutically acceptable carrier.