Patent ID: 9140697
Filing Date: 2015-09-22
Classification: B01L,G01N

Abstract:
1. A microfluidic device for capturing biological cells, comprising: a substrate comprising a nanostructured surface region; a plurality of binding agents attached to said nanostructured surface region of said substrate; and a flow layer attached to said substrate to form a microfluidic channel such that at least a portion of said nanostructured surface region of said substrate is in contact with fluid that flows through said microfluidic channel while in operation, wherein said nanostructured surface region comprises a plurality of nanostructures each having a longitudinal dimension and a lateral dimension, said longitudinal dimension being at least ten times greater than said lateral dimension, wherein biological cells are selectively captured by said binding agents and said plurality of nanostructures acting in cooperation, and wherein said flow layer comprises a textured surface that causes chaotic flow to increase the probability that said biological cells come into contact with said nanostructured surface region of said substrate to be captured.