Patent ID: 6313165
Filing Date: 2001-11-06
Classification: A61K,Y10S

Abstract:
A method of preventing in a subject in need therof a disease resulting from oxidative stress wherein oxidative stress causes oxidation of DNA bases and the disease is selected from the group consisting of rheumatoid arthritis, lupus, sickle cell anemia and cancer, which comprises administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective oxidative stress-inhibiting amount of a compound having the structure: ##STR26##whereinX and Y are independently carbonyl, C.dbd.S, S.dbd.O, or O.dbd.S.dbd.O; n and p are independently 0 or 1;R.sup.1 and R.sup.2 are independently hydrogen, linear or branched C.sub.1 -C.sub.18 alkyl, alkenyl, or alkynyl, either unsubstituted or substituted with halogen, including F, Cl, Br, and I, C.sub.1 -C.sub.6 alkoxy, (C.dbd.O)R.sup.7, or (C.dbd.O)OR.sup.8 ; wherein R.sup.7 and R.sup.8 are independently C.sub.1 -C.sub.6 linear or branched alkyl;R.sup.3, R.sup.4, and R.sup.5 are independently hydrogen, halogen, including F, Cl, Br, and I, trihalomethyl, C.sub.1 -C.sub.18 linear or branched alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkoxyalkyl, alkylthio, or (C.dbd.O)R.sup.9, (C.dbd.O)OR.sup.10, O(C.dbd.O) R.sup.11, (C.dbd.S)R.sup.12, (C.dbd.S) OR.sup.13, O(C.dbd.S)R.sup.14, (S.dbd.O)R.sup.15, (S.dbd.O)OR.sup.16, or (O.dbd.S.dbd.O)OR.sup.17 ; wherein R.sup.19, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, and R.sup.17 are independently C.sub.1 -C.sub.18 linear or branched alkyl, alkenyl, or alkynyl; andR.sup.6 is aryl or C.sub.1 -C.sub.18 branched or linear alkyl, alkenyl, or alkynyl, either unsubstituted or substituted with halogen, including F, Cl, Br, and I, C.sub.1 -C.sub.6 alkoxy, (C.dbd.O)R.sup.18, (C.dbd.O)OR.sup.19, or aryl; wherein R.sup.18 and R.sup.19 are independently C.sub.1 -C.sub.6 branched or linear alkyl;wherein when n and p are 0 and R1, R2, R3, R4, and R5 are hydrogen, R6 is not phenylethyl or a pharmaceutically acceptable salt thereof.