Patent ID: 7575746
Filing Date: 2009-08-18
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating cancer in a human, comprising administering to the human a therapeutically effective amount of a human antibody or an antigen-binding portion thereof that specifically binds to human insulin-like growth factor I receptor (IGF-1R), wherein the antibody comprises: (i) a light chain variable region that comprises three framework mutations reverted back to an amino acid sequence encoded by a germ line A30 gene and (ii) a heavy chain variable region that comprises two framework mutations reverted back to amino acid sequence encoded by a germ line DP-35 gene, and wherein the light chain variable region of the antibody comprises amino acid numbers 23 to 130 of SEQ ID NO: 5 and the heavy chain variable region of the antibody comprises amino acid numbers 20 to 144 of SEQ ID NO: 3.