Patent ID: 9086420
Filing Date: 2015-07-21
Classification: A61P,C07H,C12Q,G01N

Abstract:
1. A method of predicting the analgesic effect on a human patient afflicted with chronic pain by an analgesic agent that selectively inhibits human SCN9A activity comprising determining in a cDNA or mRNA from said patient the presence or absence of a polymorphism that induces a mutated SCN9A polypeptide wherein the absence of such polymorphism indicates that said agent is likely to produce an analgesic effect in said patient, wherein the presence of said polymorphism indicates that said agent is less likely to produce an analgesic effect in said patient, and wherein said mutated SCN9A polypeptide comprises the mutation Y328X, R830X, W1689X or a truncation of said polypeptide.