Patent ID: 8026266
Filing Date: 2011-09-27
Classification: A61K,A61P

Abstract:
1. A method for the treatment of painful length dependent neuropathy that is not sympathetically maintained in a patient in need thereof and having functional pain signaling primary afferent (sensory) fibers and their receptors comprising locally or topically administering to a site at or adjacent to painful areas in the patient having functional pain signaling primary afferent (sensory) fibers and their receptors, an effective amount of an alpha2-adrenergic agonist at the site of administration and not systemically, to reduce or alleviate pain from length dependent neuropathy or other neuropathy that results in pain associated with disease or damage to the pain signaling primary afferent (sensory) fibers or their receptor, that is not sympathetically maintained pain, wherein the alpha2-adrenergic agonist is a compound having the structure represented by formula I: wherein A 4 may be selected from aryl, and heteroaryl, which may be substituted by one or more radicals selected from alkyl, branched alkyl, cycloalkyl, hydroxyl, alkoxy, cycloalkylalkyl, alkoxyalkyl, aryl, alkanoyl, alkoxycarbonyl, carboxyl, amino, cyano, halogen, thioalkyl, dialkylamino, arylamino, alkylsulfinyl, alkylsulfonyl, arylsulfinyl or arylsulfonyl; wherein X is selected from thio, imino, or methylene; wherein R 7 is selected from hydrogen, lower alkyl, or oxygen-containing heterocycle; and wherein n is either 2 or 3; or a pharmaceutically acceptable salt thereof.