Patent ID: 6803376
Filing Date: 2004-10-12
Classification: A61K

Abstract:
A method for modulating metabolism of pneumococcal pathogenic bacteria comprising the step of contacting pneumococcal pathogenic bacteria with an antibacterially effective amount of a composition comprising a gemifloxacin compound, or an antibacterially effective derivative thereof, wherein said pneumococcal pathogenic bacteria is selected from the group consisting of:bacteria comprising a mutation in a quinolone resistance-determining region (QRDR) of parC, gyrA, parE, and/or gyrB; bacteria comprising a mutation in parC at S79-F or Y, D83-N, R95-C, or K137-N; bacteria comprising a mutation in gyrA at S83-A, C, F, or Y; E87-K; or S116-G; bacteria comprising a mutation in parE at D435-N or I460-V; bacteria comprising a mutation in gyrB at D435-N or E474-K; bacteria comprising at least four mutations in a QRDR of parC, gyrA, parE, and gyrB; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise a mutation in parC at S79-F or Y, D83-N, R95-C, or K137-N; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise a mutation in gyrA at S83-A, C, F, or Y; E87-K; or S116-G; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise a mutation in parE at D435-N or I460-V; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise a mutation in gyrB at D435-N or E474-K; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise at least four mutations in a QRDR of parC, gyrA, parE, and gyrB; bacteria that are ciprofloxacin-resistant, levofloxacin-resistant, sparfloxacin-resistant, grepafloxacin-resistant, or trovafloxacin-resistant, or a combination thereof, that comprise a mutation in a quinolone resistance-determining region (QRDR) of parC, gyrA, parE, and/or gyrB; Streptococcus pneumoniae bacteria comprising a mutation in parC at S79-F or Y, D83-N, R95-C, or K137-N; Streptococcus pneumoniae bacteria comprising a mutation in gyrA at S83-A, C, F, or Y; E87-K; or S116-G; Streptococcus pneumoniae bacteria comprising a mutation in parE at D435-N or I460-V; Streptococcus pneumoniae bacteria comprising a mutation in gyrB at D435-N or E474-K; Streptococcus pneumoniae bacteria comprising at least four mutations in a QRDR of parC, gyrA, parE, and gyrB; and Streptococcus pneumoniae bacteria comprising a mutation in a quinolone resistance-determining region (QRDR) of parc, gyrA, parE, and/or gyrB.