Patent ID: 7696149
Filing Date: 2010-04-13
Classification: A61K,A61P,Y10S

Abstract:
1. A method for suppressing aggregation of the LHRH antagonist salt cetrorelix acetate in a pharmaceutical composition for parenteral administration, comprising the steps of: providing a pharmaceutically effective amount of cetrorelix acetate, in a concentration of 2.5 mg/ml total solution; dissolving or dispersing cetrorelix acetate in a carrier; and including in said carrier a pharmaceutically acceptable acid and % in total solution thereof, selected from the group consisting of gluconic acid of at least 0.0071%, or glucaric acid or galacturonic acid of 2.5%, wherein the pharmaceutically acceptable acid is present as free acid and is in an amount capable of imparting a pH of 2.5 to 4.5 to the composition and suppressing aggregation of cetrorelix acetate.