Patent ID: 6468530
Filing Date: 2002-10-22
Classification: A61K,A61P,B82Y,C07K

Abstract:
A method for treating a mammal having either a multidrug resistant tumor that expresses a tumor associated antigen or a multidrug resistant disease caused by an infectious agent, said method comprising the step of:(1) administering an antibody composite to the mammal, wherein said antibody composite comprises: (a) at least one antibody component that binds with a first epitope of a multidrug transporter protein, (b) at least one antibody component that binds with a first epitope of an antigen, wherein said antigen is associated with said tumor or said infectious agent, and either (c) at least one therapeutic agent, thereby forming a polyspecific immunoconjugate, or (câ€²) a biotin-binding molecule or biotin for subsequent binding to a biotin-linked or biotin-binding molecule-linked therapeutic agent.