Patent ID: 9000048
Filing Date: 2015-04-07
Classification: A61K,A61P

Abstract:
1. A therapeutic formulation comprising: an aqueous solution; semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block, wherein said fluorophilic block is a perfluorinated linear alkyl chain having a length of 6 to 16 carbons, and wherein said hydrophilic block is a poly(ethylene glycol) block having a molecular weight selected over the range of 500 g mol a fluorinated anesthetic compound selected from the group consisting of sevoflurane, isoflurane, desflurane, enflurane and methoxyflurane; and a stabilizing additive comprising a perhalogenated fluorocarbon selected from the group consisting of perfluorooctyl bromide and perfluorodecalin; wherein said formulation is a nanoemulsion comprising a continuous phase and a dispersed phase, wherein said continuous phase comprises said aqueous solution and said dispersed phase comprises said semi-fluorinated block copolymers, said fluorinated anesthetic compound and said stabilizing additive; and wherein said fluorinated anesthetic compound is greater than or equal to 5% by volume of said therapeutic formulation, said perhalogenated fluorocarbon is 1% to 20% by volume of said therapeutic formulation; and said semi-fluorinated block copolymers have a concentration selected over the range of 1 mg ml