Patent ID: 9101606
Filing Date: 2015-08-11
Classification: A61K,A61L,A61P

Abstract:
1. A delivery system comprising: a covering configured for implantation into a bone defect site and comprising one or more polymers, the covering being porous and comprising at least one compartment, and a score line extending partially across the width of the covering; a demineralized bone matrix material comprising fully demineralized bone matrix fibers and surface demineralized bone chips in a ratio of about 25:75 to about 75:25, the demineralized bone matrix material disposed within the at least one compartment, wherein the covering retains the demineralized bone matrix material for placement at the bone defect site and facilitates transfer of cells into and out of the covering and the covering comprises a therapeutic agent disposed within the at least one compartment or on a surface of the covering, wherein the covering comprises a modulus of elasticity of about 1×10 2 to about 6×10 5 dynes/cm 2 before placement at the bone defect site, and a modulus of elasticity of 1×10 2 to about 6×10 5 dynes/cm 2 after placement at the bone defect site, and the covering comprises edges comprising a polymer that is different and more hydrophilic than the at least one or more polymers of the rest of the covering.