Patent ID: 6174548
Filing Date: 2001-01-16
Classification: A61K,A61P

Abstract:
A stable pharmaceutical dosage formulation for oral administration consisting essentially of:(a) a tabletted core consisting essentially of 5 to 70 weight percent based on the total weight of the core of omeprazole, 0.1 to 5 weight percent based on the total weight of the core of a surface active agent, 25 to 50 weight percent based on the total weight of the core of a filler, 0.1 to 10 weight percent based on the total weight of the core of a binder and 20 to 60 weight percent based on the total weight of the core of a pharmaceutically acceptable alkaline agent, wherein the alkaline agent is selected from the group consisting of lysine and arginine; and(b) a coating layer surrounding the core that consists of an enteric coating agent, 10 to 50 weight percent based on the total weight of the coating layer of an inert processing aid and 0 to 40 weight percent based on the total weight of the coating layer of a plasticizer wherein the coating layer is applied directly to the omeprazole containing core without a separating layer between the omeprazole containing core and coating layer.