Patent ID: 6641839
Filing Date: 2003-11-04
Classification: A61K,A61P

Abstract:
A controlled-release pharmaceutical formulation for once-per-day oral administration, comprising spheres having a core including sugar spheres or nonpareils coated with an isosorbide mononitrate; and a diffusion control membrane surrounding the core comprising a pharmaceutically acceptable, film forming polymer, the film forming polymer being present in an amount effective to permit release of the isosrbide monoitrate from the spheres, over a 24 hour dosing period, at a rate of release that achieves a therapeutically effective level of the isosrbide monoitrate for at least 12 hours after administration of the pharmaceutical formulation, while providing less than therapeutically effective levels of the at least one isosrbide monoitrate for the remainder of the 24 hour dosing period so as not to induce tolerance in a patient administered the pharmaceutical formulation once every 24 hours.