Patent ID: 6306892
Filing Date: 2001-10-23
Classification: A61K,C07D,C07K

Abstract:
A compound of the formula I: ##STR275##whereinX is a single bond or a straight or branched, saturated or unsaturated chain containing 1 to 6 carbon atoms, wherein one or more of the carbon atoms are optionally independently replaced with O or S, and wherein one or more of the hydrogen atoms are optionally replaced with F;Y is a single bond, --CH(OH)--, or --C(O)--;R.sub.1 is an aryl group, a heteroaryl group, a cycloalkyl group, or a heterocycloalkyl group;R.sub.2 is H, an alkyl group, an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, or C(O)R.sub.10,wherein R.sub.10 is H, an alkyl group, an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, an O-aryl group, an O-alkyl group, or NR.sub.11 R.sub.12 ;wherein R.sub.11 is H, an alkyl group, an O-alkyl group, an aryl group, a heteroaryl group, a cycloalkyl group, or a heterocycloalkyl group, andwherein R.sub.12 is H, an alkyl group, an aryl group, a heteroaryl group, a cycloalkyl group, or a heterocycloalkyl group,or wherein R.sub.11 and R.sub.12 form, together with the nitrogen to which they are attached, a heteroaryl group or a heterocycloalkyl group, andR.sub.3 is H, an alkyl group, an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, NR.sub.11 R.sub.12, or OR.sub.11 wherein R.sub.11 and R.sub.12 are as defined above,or R.sub.2 and R.sub.3, together with the atom(s) to which they are attached, form a cycloalkyl group or a heterocycloalkyl group;R4 is H or any suitable organic moiety;R.sub.5 is C(O)NHOH, C(O)OR.sub.13, SH, N(OH)CHO, SC(O)R.sub.14, P(O)(OH)R.sub.15 or P(O)(OH)OR.sub.13,R.sub.13 is H, an alkyl group, or an aryl group,R.sub.14 is an alkyl group or an aryl group, andR.sub.15 is an alkyl group; and ##STR276##is a heteroaryl group having five ring atoms, including 1, 2 or 3 S heteroatoms;or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutically acceptable prodrug thereof, said prodrug being different from a compound of the formula (I).