Patent ID: 7254487
Filing Date: 2007-08-07
Classification: C12Q,G01N,G16B,G16C

Abstract:
1. A method for evaluating specificity of a drug comprising: a) comparing activity of a drug against its target pathway (D wherein α target is a scaling constant of a scaling transformation of said target pathway, α off-target is a scaling constant of a scaling transformation of said at least one of its off-target pathways, R target, k (α target ,t l ) is a scaled response of cellular constituent k in said target pathway and R off-target, k (α off-target ,t l ) is a scaled response of cellular constituent k in said at least one of its off-target pathways, t l is a drug exposure level, β k is a constant for cellular constituent k, C target is the minimal level of said drug to achieve a threshold response in said target pathway, and C off-target is the minimal level of said drug to achieve a threshold response in said at least one of its off-target pathways; thereby evaluating specificity of said drug; and b) displaying or outputting a result of said comparing step a) to a user, a computer readable storage medium, a monitor, or a computer that is part of a network.