Patent ID: 6218431
Filing Date: 2001-04-17
Classification: A61P,C07D,C07F

Abstract:
A compound having glucagon receptor antagonistic activity and the structural formula ##STR390##wherein:R.sup.1a and R.sup.1b independently represent (C.sub.1 -C.sub.6) alkyl;R.sup.2 represents (C.sub.1 -C.sub.10) alkyl, or substituted (C.sub.1 -C.sub.10) alkyl wherein the substituents are independently from 1 to 3 of --SR.sup.7 ;R7 represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkoxy, nitro, cyano, or hydroxyl;R.sup.3 represents substituted (C.sub.1 -C.sub.6) alkyl wherein the substituents are 1-2 hydroxyl groups;G represents a substituent selected from the group consisting of halogen, (C.sub.1 -C.sub.6) alkyl, and OR.sup.4, whereinR.sup.4 is H or (C.sub.1 -C.sub.6) alkyl; andy is 0 or an integer of 1-3.