Patent ID: 6468560
Filing Date: 2002-10-22
Classification: A61K

Abstract:
A controlled release oral dosage form containing [R-(Z)]-&agr;-(methoxyimino)-&agr;-(1-azabicyclo [2.2.2]oct-3-yl)acetonitrile monohydrochloride (compound X) comprising a tablet of the following composition (mg/tablet):Compound X0.005-0.1 pfbhydroxymethylcellulose 28-30%methoxyl, 400 mPa s nominal viscosity(2% in water), ultra fine (95% < 100 mesh)75.0Sodium Dihydrogen Citrate0-3.00Lactose70.38-73.38Magnesium Stearate1.50hydroxypropylmethylcellulose aqueous2.25dispersion with polyethylene glycol plasticizer seal coated with a solution of hydroxypropylmethylcellulose aqueous dispersion with polyethylene glycol plasticizer in purified water at 10% solids concentrations and polymer coated with a 60% w/w (25% as solids) dispersion containing ethylcellulose latex suspension at 10% weight gain, formed into core tablets, coated with the hydroxypropylmethylcellulose aqueous dispersion with polyethylene glycol plasticizer seal coating solution and polymer coated to 4% weight gain using 60% w/w (25% as solids) dispersion containing ethylcellulose latex suspension.