Patent ID: 8642725
Filing Date: 2014-02-04
Classification: C07K

Abstract:
1. A process for producing a peptide thioester comprising the following steps (a) to (c): (a) a step of producing a first intermediate by reacting a compound A represented by the following formula (I) with a thiol group of a cysteine residue to eliminate R wherein X is a sulfur atom or an oxygen atom, and R (b) a step of reacting a compound B represented by the following formula (II) with said first intermediate in an organic solvent to add a —NH—C(═Y)NHR wherein Y is an oxygen atom, a sulfur atom or an NH group and R (c) a step of thioesterifying a C-terminal of the second intermediate by reacting thiol with the second intermediate to exchange the —NH—C(═Y)NHR