Patent ID: 7850990
Filing Date: 2010-12-14
Classification: A61K,A61P

Abstract:
1. A composition for treating cancer, which composition comprises liposomes, said liposomes having stably associated therewith at least a first antineoplastic agent and a second antineoplastic agent in a mole ratio of the first agent to the second agent which exhibits a synergistic cytotoxic or cytostatic effect on cancer cells in vitro, wherein said stable association maintains, for at least one hour, said synergistic ratio of said agents in the blood when administered in vivo, and wherein said synergistic ratio is such that when said ratio is provided to cancer cells relevant to said cancer in an in vitro assay over the concentration range at which the fraction of affected cells is 0.20 to 0.80, synergy is exhibited over at least 20% of said range; wherein said liposomes comprise at least 10 mol% of a phospholipid selected from the group consisting of phosphatidylcholine, phosphatidylglycerol, phosphatidylserine, sphingomyelin and combinations thereof and comprise 0-45 mol% cholesterol in composition in amounts that provide coordinated pharmacokinetics to said agents.