Patent ID: 6767915
Filing Date: 2004-07-27
Classification: A61K,A61P,C07D

Abstract:
A compound of structural formula I: whereinQ is Cy is selected from the group consisting of aryl, 5- or 6-membered heteroaryl, 5- or 6-membered heterocyclyl, and 5- to 7-membered carbocyclyl; wherein Cy is substituted with one to three groups independently selected from R3; A is O, S(O)m, NR7, or CH2; m is 0, 1, or 2; n is 0, 1, 2, or 3; p is 0, 1 or 2; q is 0, 1 or 2; r is 1, 2, or 3; R1 is selected from the group consisting of hydrogen, C1-8 alkyl, (CHR7)nâ€”C3-7 cycloalkyl, (CHR7)naryl, and (CHR7)nheteroaryl; in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; R2 is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)nC3-7 cycloalkyl, and (CH2)n-aryl; each R3 is independently selected from hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)nC3-7 cycloalkyl, (CH2)n-heteroaryl, halo, OR7, NHSO2R7, N(R7)2, Câ‰¡N, CO2R7, C(R7)(R7)N(R7)2, NO2, SO2N(R7)2, S(O)mR7, CF3, and OCF3; R4 and R5 are each independently selected from the group consisting of hydrogen, C1-10 alkyl, and C3-8 cycloalkyl; or R4 and R5 together with the nitrogen to which they are attached form a 5- to 8-membered ring optionally containing an additional heteroatom selected from O, S, and NR7; wherein alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; R6 is selected from the group consisting of â€ƒC1-8 alkyl, â€ƒ(CH2)n-aryl, â€ƒ(CH2)nC3-7 cycloalkyl, â€ƒ(CH2)n-heteroaryl, â€ƒhalo, â€ƒOR7, â€ƒNHSO2R7, â€ƒN(R7)2, â€ƒCâ‰¡N, â€ƒCO2R7, â€ƒC(R7)(R7)N(R7)2, â€ƒNO2, â€ƒSO2N(R7)2, â€ƒS(O)mR7, â€ƒCF3, and â€ƒOCF3; each R7 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; each R8 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)n-heteroaryl, and (CH2)nC3-7 cycloalkyl; wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, and (CH2)n are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; or two R8 groups together with the atoms to which they are attached form a 5- to 8-membered mono- or bi-cyclic ring system optionally containing an additional heteroatom selected from O, S, and NR7; R9 is hydrogen or C1-4 alkyl; X is selected from the group consisting of C1-8 alkyl, (CH2)nC3-8 cycloalkyl, (CH2)naryl, (CH2)nheteroaryl, (CH2)nheterocyclyl, (CH2)nCâ‰¡N, (CH2)nCON(R8R8), (CH2)nCO2R8, (CH2)nCOR8 (CH2)nNR8C(O)R8, (CH2)nNR8CO2R8, (CH2)nNR8C(O)N(R8)2, (CH2)nNR8SO2R8, (CH2)nS(O)mR8, (CH2)nSO2N(R8)(R8), (CH2)nOR8, (CH2)nOC(O)R8, (CH2)nOC(O)OR8, (CH2)nOC(O)N(R8)2, (CH2)nN(R8)(R8), and (CH2)nNR8SO2N(R8)(R8); wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups selected from R6, and alkyl, (CH2)n, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to four groups independently selected from R6 and oxo; Y is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)nC3-8 cycloalkyl, (CH2)naryl, (CH2)nheterocyclyl, and (CH2)nheteroaryl; wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups selected from R6; and alkyl, (CH2)n, cycloalkyl, and heterocyclyl are optionally substituted with one to three groups selected from R6 and oxo; or a pharmaceutically acceptable salt thereof.