Patent ID: 6190872
Filing Date: 2001-02-20
Classification: G01N

Abstract:
A method of identifying a patient at risk for developing a selected systemic inflammatory condition prior to development of signs and symptoms which are diagnostic of the selected systemic inflammatory condition comprising;a) measuring selected physiological parameters in the patient, wherein measured selected physiologic parameters comprise physical examination, vital signs, hemodynamic measurements and calculations, clinical laboratory tests and concentrations of acute inflammatory response mediators, wherein said acute inflammatory response mediators comprise prostaglandin 6-keto F1.alpha., thromboxane B.sub.2, leukotrienes B.sub.4, C.sub.4, D.sub.4 and E.sub.4, interleukin 1.beta., interleukin-6, interleukin-8, tumor necrosis factor, neutrophil elastase, complements C3a and C5a, platelet activating factor, nitric oxide metabolites and endotoxin levels;b) producing a systemic mediators-associated response test profile for the patient, wherein said systemic mediators-associated response test profile comprises the physiological parameters set forth in step (a); andc) comparing said profile with an established control profile to identify the patient as being at risk for developing a selected systemic inflammatory condition prior to development of signs and symptoms which are diagnostic of the selected systemic inflammatory condition wherein the systemic inflammatory condition is selected from a group consisting of Adult Respiratory Distress Syndrome, Systemic Inflammatory Response Syndrome, sepsis, Multiple Organ Dysfunction Syndrome, single organ dysfunction, shock, transplant rejection, cancer and trauma.