Patent ID: 8589082
Filing Date: 2013-11-19
Classification: G16H

Abstract:
1. A method for lowering the risk of developing blood-glucose-spike-induced diseases, or for managing the said diseases, if already developed, the method comprising the steps of: (a) generating, through measurements, a person-specific profile of glucose concentration vs. time for at least one significant meal, the profile indicating the timing and the amplitude of a glucose spike; (b) tuning or training a blood glucose response model with the measured person-specific blood glucose profile data for at least one meal to determine the best-fit values of meal-specific and person-specific parameters in the tuned model, or to obtain a trained blood glucose response model; wherein the blood glucose response model is a kinetic model for the reactions of carbohydrates (C) to glucose (G) to glycogen (GLY) and energy (E): C→G→GLY and E that yields a mathematical expression relating the blood glucose level at any time t since taking a meal with three measurable or known factors, and three tunable parameters, the said kinetic model is as shown by: where, G is the blood glucose concentration at any time following a meal, in mmol/L; Go is the blood glucose concentration prior to taking a meal, in mmol/L; Co is carbohydrate ingested during a meal, in g; BV is the blood volume of the person, in liters; CMW is a meal-specific tunable parameter representing the average molecular weight of the carbohydrates ingested during a meal, in g/mol; k1 is a person-specific tunable parameter representing the rate constant for the reaction C→G, in min k2 is a person-specific tunable parameter representing the rate constant for the reaction G→GLY and E, in min t is the time from the start of the most recent meal, in min; wherein the said kinetic model is tuned with the person-specific glucose profile data to determine the best-fit or the tuned values of CMW, k1 and k2, and which values are then used along with pre-meal Go, Co ingested, and BV to calculate: wherein at least one of which calculated values (G, tspike, Gmax or glucose shock) is used to develop a meal plan and/or a post-prandial exercise plan to keep the glucose spike, or the glucose shock following a meal within a target level, thereby lowering the risk of developing blood-glucose-spike-induced diseases, or for managing the said diseases, if already developed. (c) using the tuned or the trained blood glucose response model to develop at least one significant meal plan and/or a post-prandial exercise plan, needed for reducing the post-prandial glucose spike, or the glucose shock, defined by the increase in area over the pre-meal area under the blood glucose concentration vs. time plot, to a target level; and (d) executing the meal and/or the post-prandial exercise plan and comparing the measured blood glucose spike, or the glucose shock with a target range to assess the success of the glucose spike reduction plan, and readjusting, if necessary, the meal and/or the post-prandial exercise plan using the tuned or the trained blood glucose response model.