Patent ID: 7933722
Filing Date: 2011-04-26
Classification: A61P,C12Q,Y02A

Abstract:
1. A method of assessing a human subject's risk of developing a disease having a genetic basis, comprising: obtaining a biological sample from a human subject; analyzing said sample for a presence or absence of at least one protective polymorphism and for a presence or absence of at least one susceptibility polymorphism, wherein said at least one protective polymorphism and said at least one susceptibility polymorphism are associated with a disease having a genetic basis, and wherein the total number of susceptibility and protective polymorphisms analyzed is four or greater; assigning a positive score for each protective polymorphism and a negative score for each susceptibility polymorphism or vice versa; and calculating a net score for said subject, said net score representing a balance between a combined value of the at least one protective polymorphism and the combined value of the at least one susceptibility polymorphism present in the subject sample; wherein the disease is selected from the group consisting of lung cancer, chronic obstructive pulmonary disease (COPD), occupational chronic obstructive pulmonary disease (OCOPD), and emphysema, and wherein a net protective score is predictive of a reduced risk of developing said disease and a net susceptibility score is predictive of an increased risk of developing said disease.