Patent ID: 8754048
Filing Date: 2014-06-17
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A modified Volvox carteri-derived light-receiving channel rhodopsin protein, wherein the protein is modified to comprise an N-terminal region of Chlamydomonas reinhardtii -derived channel rhodopsin-1 at the N-terminal of a Volvox carteri-derived light-receiving channel rhodopsin protein, wherein the N-terminal region imparts cell membrane-localized expression and comprises no transmembrane domain of the Chlamydomonas reinhardtii -derived channel rhodopsin-1, wherein the protein comprises (a) or (b) below: (a) the amino acid sequence shown in SEQ ID NO: 8 or SEQ ID NO: 10; (b) the amino acid sequence having at least 98% sequence identity to the amino acid sequence shown in SEQ ID NO:8 or SEQ ID NO: 10 and having biological activities equivalent to or higher than those of the polypeptides of (a), wherein the amino acid sequence comprises at least amino acids 1-66 of SEQ ID NO: 2.