Patent ID: 7780966
Filing Date: 2010-08-24
Classification: A61K,C07K,Y02A

Abstract:
1. An artificial Invaplex consisting of IpaB:IpaC complex complexed with a purified lipopolysaccharide (LPS) from a gram negative bacteria selected from S. flexneri, S. sonnei, S. dysenteriae, S. boydii, enteroinvasive E. coli, Yersinia or Salmonella , wherein the artificial Invaplex is prepared by mixing IpaB and IpaC to form a complex, IpaB:IpaC, and then mixing IpaB:IpaC with the lipopolysaccharide to form the artificial Invaplex and wherein the IpaB and the IpaC are recombinantly produced and of Shigella origin.