Patent ID: 6040320
Filing Date: 2000-03-21
Classification: A61P,C07D

Abstract:
A compound of Formula I ##STR32## wherein: one of R1 and R2 is phenyl optionally substituted by one or more of the members of the group consisting of C1-5 alkyl, halogen, nitro, trifluoromethyl and nitrile; the other is pyridyl optionally substituted by one or more of the members of the group consiting of C1-5alkyl and halogen;R.sub.3 is hydrogen, SEM, C.sub.1-5 alkoxycarbonyl, aryloxycarbonyl, aryiC.sub.1-5 alkyloxycarbonyl, arylC.sub.1-5 alkyl, phthalimidoC.sub.1-5 alkyl, aminoC.sub.1-5 alkyl, diaminoC.sub.1-5 alkyl, succinmidoC.sub.1-5 alkyl, C.sub.1-5 alkylcarbonyl, arylcarbonyl, C.sub.1-5 alylcarbonylC.sub.1-5 alkyl, aryloxycarbonylC.sub.1-5 alkyl, orsubstituted arylC.sub.1-5 alkylwherein the aryl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, halogen, amino, C.sub.1-5 alkylamino, and diC.sub.1-5 alkylamino;R.sub.4 is (A).sub.n -(CH.sub.2).sub.q -X wherein:A is sulfur;n is 1;q is 0-9;X is selected from the group consisting of amino, C.sub.1-5 alkylamino, phthalimido, amido, phenylcarbonyl, C.sub.1-5 alkylaminocarbonyl, phenylaminocarbonyl, arylC.sub.1-5 alkylaminocarbonyl, C.sub.1-5 alkylsulfonyl, phenylsulfonyl,substituted amidowherein the carbonyl substituent is selected from the group consisting of C.sub.1-5 alkyl, phenyl, arylC.sub.1-5 alkyl, thienyl, furanyl, and naphthyl,substituted phenylcarbonylwherein the phenyl substituents are independently selected from one or members of the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy,substituted C.sub.1-5 alkylsulfonylwherein the alkyl substituent is selected from the group consisting of hydroxy and phthalimido,substituted phenylsulfonylwherein the phenyl substituents are independently selected from one or members of the group consisting of bromine, fluorine, chlorine, C.sub.1-5 alkoxy and trifluoromethyl,with the proviso:if A is sulfur and X is other than, C.sub.1-5 alkylaminocarbonyl, phenylarninocarbonyl, arylC.sub.1-5 alkylaminocarbonyl, C.sub.1-5 alkylsulfonyl or phenylsulfonyl, then q must be equal to or greater than 1;and pharmaceutically acceptable salts thereof.