Patent ID: 6555372
Filing Date: 2003-04-29
Classification: A61K,C07H

Abstract:
A method for treating tumors in a mammal in need thereof, comprising:administering to the mammal an effective amount of the tumor cell that has been in in vitro contact with the compound of formula (I): whereinR1 represents H or OH, X represents an integer between 7 and 27, R2 represents a substituent selected from the group consisting of the following (a) to (e) (wherein Y represents an integer between 5 and 17): (a) â€”CH2(CH2)YCH3 (b) â€”CH(OH)(CH2)YCH3 (c) â€”CH(OH)(CH2)YCH(CH3)2 (d) â€”CH&boxH;CH(CH2)Y(CH3) (e) â€”CH(OH)(CH2)YCH(CH3)CH2CH3, and R3 to R9 represent substituents as defined in any one of the following i) and ii): i) when R3, R6 and R8 represent H, R4 represents H, OH, NH2, NHCOCH3, or a substituent selected from the group consisting of the following groups (A) to (D): R5 represents OH or a substituent selected from the group consisting of the following groups (E) and (F): R7 represents OH or a substituent selected from the group consisting of the following groups (A) to (D): R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (Aâ€²) to (Dâ€²): ii) when R3, R6 and R7 represent H, R4 represents H, OH, NH2, NHCOCH3, or substituent selected from the group consisting of the following groups (A) to (D): R5 represents OH or a substituent selected from the group consisting of groups (E) and (F): R8 represents OH or a substituent selected from the group consisting of the following groups (A) to (D): R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (Aâ€²) to (Dâ€²): or a salt or solvate thereof.