Patent ID: 6369049
Filing Date: 2002-04-09
Classification: A61P,C07D

Abstract:
A compound of the formula whereinRa, Rb, Rc, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)nâ€” group having at least one fluorine substituent; Z is O, S, â€”SOâ€”, or â€”SO2â€”; m and n independently are 0 or 1; and R1 is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy; or a physiologically acceptable salt thereof; provided that:1) at least one of Ra, Rb, Rc, Rd or Re is other than hydrogen; and 2) when Rc is F, or one of Rb or Rd is CF3, at least one of the remaining Ra, Rb, Rc, Rd or Re is other than hydrogen.