Patent ID: 6455591
Filing Date: 2002-09-24
Classification: A01N,A61K,C07C,C07D,Y10S

Abstract:
An anti-diarrheal or gastrointestinal anti-spasmodic pharmaceutical composition comprising an anti-diarrheal, gastrointestinal anti-secretory, nitric oxide agonist or nitric oxide synthase activating or gastrointestinal anti-spasmodic effective amount of a compound having the formula: â€ƒR1â€”N1Hâ€”(CH2)3â€”N2Hâ€”(CH2)3â€”N3Hâ€”(CH2)4â€”N4Hâ€”(CH2)3â€”N5Hâ€”(CH2)3â€”N6Hâ€”R6â€ƒâ€ƒ(II);or wherein:R1 and R6 may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that, in formula (I), R1 and R6 are not H; R2-R5 may be the same or different and are H, R1 or R6; R7 is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV) a salt thereof with a pharmaceutically acceptable acid; and a pharmaceutically acceptable carrier therefor.