Patent ID: 6572867
Filing Date: 2003-06-03
Classification: A61K,A61P,C07K

Abstract:
A composition useful for reducing plasma levels of anti-(&agr;Gal(1,3)Gal) antibodies in a primate subject, said composition comprising:a plurality of non-immunogenic polymers, wherein each of said non-immunogenic polymers comprises a plurality of &agr;Gal(1,3)Gal moieties covalently linked to said non-immunogenic polymer; and a plurality of cross-links between adjacent non-immunogenic polymers, wherein said cross-links are covalent tethers, derived from N-hydroxysulfosuccinimide, between a hydroxy group of an &agr;Gal(1,3)Gal moiety on a first non-immunogenic polymer and a hydroxy group of an &agr;Gal(1,3)Gal moiety on a second non-immunogenic polymer.