Patent ID: 6503900
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 and R2 are independently selected from hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluorinated alkyl of 1-6 carbon atoms, â€”CN, â€”NHâ€”SO2-alkyl of 1-6 carbon atoms, â€”SO2â€”NH-alkyl of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluorinated alkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, phenoyl or thiophenoyl; R3, R4, R5 and R6 are independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy or C3-C6 cycloalkoxy; R7 is hydrogen or C1-C6 alkyl; R8 is hydrogen or C1-C6 alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof; provided that when R1 or R2 is hydrogen, halogen or alkyl of 1 to 6 carbon atoms, at least one of R3, R4, R5 or R6 is not hydrogen.