Patent ID: 7998698
Filing Date: 2011-08-16
Classification: A61P,C12Q,G01N

Abstract:
1. A method for determining whether an individual is likely to be susceptible to radiation pneumonitis comprising: determining in a red blood cell sample obtained from the individual enzymatic activity of glutathione peroxidase (GPX), or enzymatic activity of superoxide dismutase (SOD), or a ratio of GPX and SOD enzymatic activity, wherein: determining an SOD enzymatic activity that is higher than a normal control indicates that the individual is likely to be susceptible to radiation pneumonitis; determining an SOD enzymatic activity that is not higher than a normal control is indicative that the individual is likely not to be susceptible to radiation pneumonitis; determining a GPX enzymatic activity that is lower than a normal control is indicative that the individual is likely to be susceptible to radiation pneumonitis; determining a GPX enzymatic activity that is not lower than a normal control is indicative that the individual is likely not to be susceptible to radiation pneumonitis; determining a ratio of GPX enzymatic activity to SOD enzymatic activity that is lower than a normal control is indicative that the individual is likely to be susceptible to radiation pneumonitis; and/or determining a ratio of GPX enzymatic activity to SOD enzymatic activity that not lower than a normal control is indicative that the individual is likely not to be susceptible to radiation pneumonitis.