Patent ID: 6469023
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A stereochemically pure (N1-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivative represented by formula (I): wherein X1 represents a halogen atom; X2 represents a halogen atom; R1 represents an amino group, a hydrogen atom, a hydroxyl group or a methyl group; R2 is a group represented by formula (II): â€ƒwherein R3 and R4 independently represents a hydrogen atom and m is an integer of 1: A represents a partial structure of formula (III): â€ƒwherein X3 represents a methyl group; and R represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a pthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxo-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbonatoms or a phenyl alkyl group composed of alkylene group having 1 to 6 carbon atoms and a phenyl group; or a salt thereof.