Patent ID: 6010861
Filing Date: 2000-01-04
Classification: C07K,G01N

Abstract:
A method of identifying a potential drug candidate capable of binding to at least one site of a biologically active target, which site is capable of conferring a biological response, and wherein said potential drug candidate exhibits either agonist or antagonist activity at the target, the method comprising:a) providing at least one detectable reporter of binding of said potential drug candidate to the biologically active target, wherein said reporter possesses agonist or antagonist activity at said target and wherein said reporter is selected from a recombinant library of antibodies comprising at least one variable region;b) screening potential drug candidates by assaying for the ability of the potential drug candidates to compete with the reporter for binding to the target; andc) selecting potential drug candidates possessing agonist or antagonist activity, which compete with the reporter for binding to the target.