Patent ID: 9101508
Filing Date: 2015-08-11
Classification: A61F,A61K,A61L,D04H

Abstract:
1. An electro spun nanofibrous wound dressing comprises: a first nanofibrous layer, and wherein the first nanofibrous layer is a polymeric layer, and wherein the first nanofibrous layer is an outer supporting layer, and wherein the first nanofibrous layer is hydrophobic in nature; a second nanofibrous layer, and wherein the second nanofibrous layer is a polymeric layer, and wherein the second nanofibrous layer is a genipin cross linked middle reservoir layer loaded with a herbal extract, wherein the genipin is present in the second nanofibrous layer at a ratio of 0.5-10% of chitosan by weight, and wherein a cross-linking of the chitosan based nanofibers with genipin decreases an initial burst release of a herbal extract and prolongs a release rate of the herbal extract, and wherein the second nanofibrous layer is hydrophobic or hydrophilic in nature, and wherein the herbal extract is a a third nanofibrous layer, and wherein the third nanofibrous layer is a polymeric layer, and wherein the third nanofibrous layer is a wound contacting inner layer, and wherein the third nanofibrous layer is a non-cross-linked chitosan based nanofibrous layer, and wherein the third nanofibrous layer is hydrophilic in nature; and additives, wherein the additives are selected from a group consisting of surfactants, block-co-polymers, salts and rubbers, and wherein the additives enhances a mechanical property and a chemical property of the wound dressing and wherein the additives controls a release profile of the herbal extract.