Patent ID: 6933388
Filing Date: 2005-08-23
Classification: A61P,C07D

Abstract:
1. A process for the production of a 3-cyano-6-alkoxy-7-nitro-4-quinolone comprising: a) reacting a substituted anthranilate of formula (I) with dimethylformamide dimethyl acetal:  wherein R and R  to obtain a compound of formula (II): b) condensing the compound of formula (II) with t-butylcyanoacetate to obtain a compound of formula (III): c) hydrolyzing the compound of formula (III) to yield compound of formula (IV): d) decarboxylating the compound of formula (IV) to a compound of formula (V): e) cyclizing the compound of formula (V) to obtain a 3-cyano-6-alkoxy-7-nitro-4-quinolone of formula: