Patent ID: 9109228
Filing Date: 2015-08-18
Classification: C12N

Abstract:
1. A method for preventing or treating a disease or condition associated with CD154-CD40 interactions comprising administering to a subject in need of treatment an agent which modulates the level or activity of hnRNP L protein, wherein said agent comprises purified hnRNP L protein, a recombinant expression vector expressing hnRNP L, or a recombinant expression vector expressing a siRNA which binds hnRNP L mRNA, and wherein said disease or condition comprises allograft rejection, allergy, atherosclerosis, drug-induced lupus, systemic lupus erythematosus, adult rheumatoid arthritis, juvenile rheumatoid arthritis, scleroderma, Sjogren's Syndrome, Epstein-Barr infection, or retroviral infections, so that the disease or condition associated with CD154-CD40 interactions is prevented or treated.