Patent ID: 6683108
Filing Date: 2004-01-27
Classification: A61K,C07D

Abstract:
A method for agonizing the hedgehog pathway in a cell, comprising contacting the cell with a hedgehog agonist represented in general formula (II): whereinAr and Arâ€² independently represent substituted or unsubstituted aryl or heteroaryl rings; Y, independently for each occurrence, is absent or represents â€”N(R)â€”, â€”Oâ€”, â€”Sâ€”, or â€”Seâ€”; X is selected from â€”C(&boxH;O)â€”, â€”C(&boxH;S)â€”, â€”S(O2)â€”, â€”S(O)â€”, â€”C(&boxH;NCN)â€”, â€”P(&boxH;O)(OR)â€”, and a methylene group optionally substituted with 1-2 groups selected from lower alkyl, alkenyl, and alkynyl groups; M represents, independently for each occurrence, a substituted or unsubstituted methylene group, or two adjacent M taken together represent substituted or unsubstituted ethene or ethyne, wherein some or all occurrences of M in Mj form all or part of a cyclic ring; R represents, independently for each occurrence, H or substituted or unsubstituted aryl, heterocyclyl, heteroaryl, aralkyl, heteroaralkyl, alkynyl, alkenyl, or alkyl, or two R taken together may form a 4- to 8-membered ring; Cyâ€² represents substituted or unsubstituted aryl, heterocyclyl, heteroaryl, or cycloalkyl; j represents, independently for each occurrence, an integer from 0 to 10; and i represents, independently for each occurrence, an integer from 0 to 5.