Patent ID: 7666888
Filing Date: 2010-02-23
Classification: A61P,C07D

Abstract:
1. A compound according to formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: wherein A-B represents O—N, or N(H)—N; each R R ring Q, together with the nitrogen atom it contains, is a cyclic moiety according to formula IIa or IIb: wherein R R R any two of R X and Y are independently selected CR′ Z is O or CR′ wherein any cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or fused polycycle is optionally substituted with from one to four members selected from the group consisting of oxo, halogen, —CN, —NO each occurrence of R′ is independently selected from the group consisting of H, C each occurrence of R″ is independently an unsubstituted member selected from the group consisting of C m and n are integers independently selected from 0, 1, 2, and 3; provided that the compound is not: 4-[[3-methyl-5-(2,3,4,5-tetrafluoro-6-hydroxyphenyl)-4-isoxazolyl]carbonyl]-morpholine 1-[(5-phenyl-4-isoxazolyl)carbonyl]-piperidine 4-[(5-phenyl-4-isoxazolyl)carbonyl]-morpholine 4-[[3-(5-chloro-2,4-dihydroxyphenyl)-1H-pyrazol-4-yl]carbonyl]-morpholine 4-[[3-(3,4-dimethoxyphenyl)-1H-pyrazol-4-yl]carbonyl]-morpholine