Patent ID: 8475764
Filing Date: 2013-07-02
Classification: A61K,C07K

Abstract:
1. An adrenomedullin derivative comprising a peptide and an active agent, wherein the peptide is: X1-X2-X3-X4-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr (SEQ ID NO:3), wherein: X1 is absent or is selected from the group consisting of: Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly, Ser-Phe-Gly and Gly-Gly-Ala-Gly; X2 is Cys or HomoCys; when X1 is Ser-Phe-Gly or Gly-Gly-Ala-Gly, X3 is Arg-Phe-Gly-Thr or a linear or branched PEG moiety having at least two Poly(ethylene glycol) (PEG) subunits; when X1 is absent or Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly, X3 is a linear or branched PEG moiety having at least two Poly(ethylene glycol) (PEG) subunits; and X4 is Cys or HomoCys.