Patent ID: 6022541
Filing Date: 2000-02-08
Classification: A61K,A61P,B82Y,C07K

Abstract:
A mixed immunological preparation for concurrent specific binding to multiple epitopes presented by spatially exposed regions of immobilized vascular permeability factor (VPF) bound in-vivo to endothelial cells of a tumor-associated blood vessel, said immunological preparation comprising not less than two types of conjugate molecules in admixture,(a) wherein a first type of conjugate molecule comprisesat least the binding portion of a first antibody which binds specifically to an epitope presented by a spatially exposed region of VPF bound to a tumor associated blood vessel in-vivo, anda single type of effector moiety covalently bound to said first antibody; and(b) wherein a second type of conjugate molecule comprisesat least the binding portion of a second antibody which binds specifically to another epitope presented by a spatially exposed region of VPF bound to a tumor-associated blood vessel in-vivo, andsaid single type of effector moiety covalently bound to said second antibody.