Patent ID: 8354534
Filing Date: 2013-01-15
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula II: or its geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein: R Q is absent or selected from (C═O), (SO W is O, S, NOR R 3 is independently selected from the group consisting of: (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocyclic or substituted heterocyclic; and (iv) —C R 4 is hydrogen, OR a , or NR b -Q 1 -R c , where Q 1 is absent or selected from (C═O) or (SO 2 ); R 5 is (C═W)NR b R c ; Y is hydrogen, lower alkyl, or lower alkoxy; V 1 is C═O, C 1 -C 6 alkylene, or substituted alkylene; V 2 is absent, alkylene, substituted alkylene, or C═O; V 3 is absent; V 4 is absent; n is 1, 2, 3 or 4; wherein each repeating unit can be the same or different; Z is (C═W)OH or C(O)NHOH; alternatively, can be selected from natural amino acids; and denotes a carbon-carbon single or double bond.