Patent ID: 8129371
Filing Date: 2012-03-06
Classification: A61P,C07D

Abstract:
1. A compound of the Formula (Ia): or pharmaceutically acceptable salts thereof, wherein: het is a 5-10-membered bridged heterobicyclyl-group containing at least one oxygen atom, at least one nitrogen atom, and optionally additional heteroatoms selected from oxygen, sulfur and nitrogen, and is connected to the pyrazolopyrimidinyl group through one of the nitrogen atoms; R t is 0-16; each R heteroaryl optionally substituted with from 1 to 3 substituents independently selected from C m is 0, 1, 2, 3, or 4; r is 0 or 1; each R or R each s is independently 1 or 2; R R with the proviso that when m>1, two R R R C R Ar is phenyl, naphthyl, or a monocyclic or bicyclic ring system having from 5 to 14 ring members, and containing at least one ring nitrogen atom, wherein the phenyl, naphthyl, and monocyclic or bicyclic ring system is optionally substituted with from 1 to 3 substituents independently selected from C