Patent ID: 8822449
Filing Date: 2014-09-02
Classification: A61P,C07D

Abstract:
1. A compound of the formula I in which A is a phenyl radical where one or more hydrogen atoms in said phenyl radical may be replaced by substituents R1 which are selected independently of one another from the group of F, Cl, Br, I, (C where said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkyloxy, cycloheteroalkyl, alkoxy, and alkylthio radicals may be substituted independently of one another one or more times by F, OH or (C B is a mono-or fused bicyclic radical selected from the group of 6to 10 membered aryl radicals, of 5 to 10 membered heteroaryl radicals, of 3 to 10 membered cycloalkyl radicals, of 9 to 14 membered cycloalkylaryl radicals, of 8 to 14 membered cycloalkylheteroaryl radicals, of 3 to 10 membered cycloheteroalkyl radicals, of 9 to 14 membered cycloheteroalkylaryl radicals and of 8 to 14 membered cycloheteroalkylheteroaryl radicals, where the cycloalkyl or cycloheteroalkyl units may be saturated or partly unsaturated, and where the heterocyclic groups may comprise one or more heteroatoms selected from the group of nitrogen, oxygen and sulfur; where one or more hydrogen atoms in the radicals B may be replaced by substituents R5which are selected independently of one another from the group of (C the cycloalkyl and cycloheteroalkyl units may be saturated or partly unsaturated, and where one or more hydrogen atoms in said radicals R5 may be replaced by further radicals which are selected independently of one another from the group of R11 radicals, it is further possible for R5 to be one or more radicals which are selected independently of one another from the group of OH, (═O), NH R16, R17 and R18 independently of one another for a radical selected from the group of H, (C all of which may be substituted independently of one another by OH, (═O), F, Cl, Br, I, CN, NO and where R17 and R18 can form together with the nitrogen to which they are bonded a 4-7 membered, saturated, unsaturated or partly unsaturated heterocycle having 1 to 13 carbon atoms which may additionally comprise one or more heteroatoms from the list —O—, —S(O) L is a covalent bond; X is a group —O—; R2 is absent or is one or more substituents which may be selected independently of one another from the group of F, (C R3 and R4 are independently of one another a radical which is selected from the group of (C R8 in the group —NR8- may form with the ring which R3 and R4 may form a further saturated, unsaturated or partly unsaturated heterocycle which may be substituted independently of one another one or more times by radicals selected from the group of R7 and R9, and may additionally comprise one or more heteroatoms from the list —O—, —S(O) R7 are a (C R8 is H, a (C R9 is a radical selected from the group of OH, (═O), F, Cl, Br, I, CN, NO R10 is a radical selected from the group of F, OH, CN, (C R11 is a radical selected from the group of (C R12, R13 and R14 may independently of one another be H, (C R13 and R14 may form together with the nitrogen to which they are bonded a 4-7 membered, saturated, unsaturated or partly unsaturated heterocycle having 1 to 13 carbon atoms, which may additionally comprise one or more heteroatoms from the list —O—, ═N— and —NR15-, where the formed heterocycle may be substituted independently of one another one or more times by F, OH, (═O), NH R15 is a radical selected from the group of H, (C R19 is an H, a (C and in which n is 0, 1or 2; p is 1and q is 0, and the pharmaceutically acceptable salts thereof, and in which i) in the case where A is phenyl, B is phenyl or benzodioxolanyl and R3 and R4 are (C ii) in the case where A is phenyl and R3 and R4 are a (C