Patent ID: 6299874
Filing Date: 2001-10-09
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
A method of improving the safety of a vaccine virus that produces protective immunity against a viral disease in an animal subject, said method comprising:administering to the animal subject a vaccine complex comprising a live vaccine virus and antibodies bound to said live vaccine virus;wherein said live vaccine virus is capable of producing a protective immune response in said animal subject;said antibodies are specific for said live vaccine virus and able to neutralize said live vaccine virus if provided in neutralizing amounts, said antibodies provided in an amount which reduces the pathology that would occur in the animal subject due to the administration of the live vaccine virus compared to that which would occur if the live vaccine virus were administered without complexed antibodies, and said antibodies provided in an amount insufficient to neutralize said virus; andsaid vaccine complex administered in an amount effective to produce a protective immune response to the live vaccine virus in the animal subject.