Patent ID: 8962239
Filing Date: 2015-02-24
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of diagnosing and treating catabolism-related vitamin D deficiency or a susceptibility thereto in a patient having Chronic Kidney Disease, comprising: requesting a test providing the results of a measurement, direct or indirect, of a patient's CYP24 expression and/or activity, wherein abnormally elevated CYP24 expression and/or activity indicates a susceptibility for catabolism-related vitamin D deficiency; and administering an effective amount of a pharmaceutically acceptable formulation comprising a CYP24 inhibitor to the patient in response to abnormally elevated CYP24 expression and/or activity to treat or prevent catabolism-related vitamin D deficiency defined as a total serum level of 25-hydroxyvitamin D below 30 ng/mL.