Patent ID: 7847120
Filing Date: 2010-12-07
Classification: A61K

Abstract:
1. A method for the preparation of a composition comprising an allosteric effector compound that is substantially free of polymeric impurities said method comprising the steps of: a) coupling a substituted aniline with 4-hydroxyphenylacetic acid to yield the corresponding substituted phenol; b) adding the product of step (a) to an alkyl ester halide to yield a substituted ethyl ester; and c) saponifying the substituted alkyl ester to provide the salt of the acid, wherein all steps are performed in a reaction vessel that does not, either in the reaction mixture or in the material constituting the reaction vessel itself, contain metals that promote the formation of polymeric byproducts, wherein said polymeric impurity is present in the composition at less than about 500 ppm.