Patent ID: 8460653
Filing Date: 2013-06-11
Classification: A61K,A61P,C12N,C12Q,C12Y,G01N

Abstract:
1. A variant superoxide dismutase-2 (SOD2) polypeptide, wherein the variant SOD2 polypeptide comprises amino acid substitutions of at least K53 and K89 compared to the amino acid sequence set forth in SEQ ID NO: 1, wherein the variant SOD2 polypeptide comprises an amino acid sequence having at least 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and wherein the variant SOD2 polypeptide exhibits superoxide dismutase enzymatic activity that is at least 50% higher than the superoxide dismutase enzymatic activity of a SOD2 polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1.