Patent ID: 6376490
Filing Date: 2002-04-23
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof,wherein R is a 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-4-yl or tetrazol-5-yl said R being optionally substituted by 1 or 2 substituents each independently selected from C1-C4 alkyl, C2-C4 alkenyl, C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, C3-C7 cycloalkyloxy, â€”COOH, C1-C4alkoxycarbonyl, â€”CONR3R4, â€”NR3R4, â€”S(O)p(C1-C4 alkyl), â€”SO2NR3R4, aryl, aryloxy, aryl(C1-C4)alkoxy quinolinyl and het, said C1-C4alkyl being optionally substituted by C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, halo(C1-C4)alkoxy, C3-C7 cycloalkyloxy, C3-C7 cycloalkyl(C1-C4)alkoxy, â€”COOH, C1-C4 alkoxycarbonyl, â€”CONR3R4, â€”NR3R4, â€”S(O)p(C1-C4 alkyl), â€”SO2(aryl), â€”SO2NR3R4, morpholino, aryl, aryloxy, aryl(C1-C4)alkoxy or het, and said C2-C4 alkenyl being optionally substituted by aryl; R1 and R2 are each independently selected from H, fluoro, chloro, bromo, C1-C4 alkyl and halo(C1-C4)alkyl; R3 and R4 are either each independently selected from H and C1-C4 alkyl or, when taken together, are C5-C7 alkylene; p is 0, 1 or 2; â€œarylâ€ , used in the definition or aryl, aryloxy, aryl(C1-C4)alkoxy moieties in R and in the definition or aryl and arylalkyl moieties in â€œhetâ€ , means phenyl or naphthyl, each optionally substituted by 1 or 2 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, hydroxy, halo, halo(C1-C4)alkyl and â€”NR3R4; â€œhetâ€ , used in the definition or R, means furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, triazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl, each being optionally substituted by 1 or 2 substituents each independently selected from C1-C4 alkyl, C3-C7 cycloalkyl, C1-C4 alkoxy, halo, hydroxy, â€”COOH, C1-C4 alkoxycarbonyl, allyloxycarbonyl, â€”CONR3R4, â€”NR3R4 â€”S(O)p(C1-C4alkyl), â€”SO2â€”NR3R4, halo (C1-C4)alkyl, hydroxy(C1-C4)alkyl, C1-C4 alkoxy(C1-C4)alkyl, R3R4NCO(C1-C4)alkyl, aryl, arylalkyl, and/or by an oxido substituent on a ring nitrogen heteroatom when â€œhetâ€  a pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl group.