Patent ID: 6136438
Filing Date: 2000-10-24
Classification: B01J,Y10T

Abstract:
A method for the modification of a silanol- or silanol group containing stationary support phase with calixarene for monomolecular covering of the support surface for chromatography comprising(a) reacting said silanol group of said stationary support with a dialkylsilane of the formula: ##STR3## to form a modified stationary support, wherein each R is the same or different and is an hydrocarbyl group which is an alkyl, cyclicalkyl or aryl group wherein said hydrocarbyl group may optionally contain a heteroatom, andX=N--R, O, S or Se,(b) and then reacting the linkage of an olefinic group which is present in said calixarene and has the formula ##STR4## with the silane functionality of said modified stationary support under heterogeneous hydrosilylation reaction conditions, where in the formula of the calixarene,n is 3 to 12;R.sup.1 is H, OR.sup.4, SR.sup.4, N(R.sup.4).sub.2, or N.sup.+ (R.sup.4).sub.3 ;R.sup.2 is H, R.sup.4, OR.sup.4, SR.sup.4, N(R.sup.4).sub.2, or N.sup.+ (R.sup.4).sub.3 ;R.sup.3 is H, R.sup.4, OR.sup.4, SR.sup.4 N(R.sup.4).sup.2, N.sup.+ (R.sup.4).sub.3, COR.sup.4, COOR.sup.4, CON(R.sup.4).sup.2, N.dbd.NR.sup.4, or SO.sub.3 R.sup.4each Z is independently C(R.sup.4).sub.2, R.sup.4 ' OR.sup.4 ', Si(R.sup.4).sub.2, O, R.sup.4, S, or N--R.sup.4 ;each R.sup.4 in calixarene is independently hydrogen, halogen, a hydrocarbyl group which is linear or branched or cyclic, which hydrocarbyl group is saturated or unsaturated, wherein the carbon atom in said hydrocarbyl group may optionally be replaced with a heteroatom;each R.sup.4' is the same or different and is alkylene, provided R.sup.1 and/or R.sup.3 contains at least one unsaturated group of the formula CH.dbd.CH.sub.2.