Patent ID: 8027033
Filing Date: 2011-09-27
Classification: A61B,G01N

Abstract:
1. A method for estimating a target analyte concentration from a test spectrum collected from a sample, the method comprising: accessing a first spectral data set that includes a plurality of spectra collected from different samples, the first spectral data set including a training data set of training spectra and a test data set of test spectra; estimating target analyte concentrations for the spectra in the first spectral data set; estimating sample-to-sample variations other than variations of the target analyte concentration, for the samples represented in the first spectral data set, wherein estimating sample-to-sample variations comprises: generating, by a computer, a model that predicts target analyte concentration based at least in part on a test spectrum and the test spectrum's sample, the model generated based at least in part on the estimated target analyte concentrations, on the estimated residual sample-to-sample variations estimated from the generated second spectral data set, and on independently measured target analyte concentrations for the training spectra; and applying the model to the test spectra to estimate the target analyte concentrations.