Patent ID: 6605599
Filing Date: 2003-08-12
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:Q is selected from the group consisting of: G is selected from the group consisting of alkyl; substituted alkyl; substituted aryl; a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; W is O or NR15; X is O or H, H; Y is selected from the group consisting of O; H, OR16; OR17, OR17; NOR18; H,NHOR19; H, NR20R21; H, H; and CHR22; wherein OR17, OR17 can be a cyclic ketal; Z1 and Z2 are independently CH2; B1 and B2 are independently selected from the group consisting of OR24, OCOR25, and Oâ€”C(&boxH;O)â€”NR26R27, and when B1 is OH and Y is OH, H, they can form a six-membered ring ketal or acetal; R1, R2, R3, R4, R5, R7, R13, R14, R18, R19, R20, R21, R22, R26 and R27 are selected from the group consisting of H, alkyl, substituted alkyl, and aryl, and when R1 and R2 are alkyl can be joined to form a cycloalkyl, and when R3 and R4 are alkyl can be joined to form a cycloalkyl; R6is methyl; R9, R10, R16, R17, R24, R25 and R31 are selected from the group consisting of H, alkyl, and substituted alkyl; R11, R12, R28, R30, R32, and R33 are selected from the group consisting of H; alkyl; substituted alkyl; aryl; substituted aryl; cycloalkyl containing 1 to 3 rings and 3 to 7 carbons per ring which may be further fused with an unsaturated C3-C7 carbocyclic ring; and a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; R8 is hydrogen or methyl; R15, R23 and R29 are selected from the group consisting of H; alkyl; substituted alkyl; aryl; substituted aryl; cycloalkyl containing 1 to 3 rings and 3 to 7 carbons per ring which may be further fused with an unsaturated C3-C7 carbocyclic ring; a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; R32C&boxH;O; R33SO2; hydroxy; O-alkyl or O-substituted alkyl; or pharmaceutically acceptable salts thereof, hydrates, solvates or geometric, optical or stereoisomers thereof; with the proviso that compounds wherein W and X are both O; and R1, R2 and R7 are H; and R3, R4 and R6 are methyl; and R8 is H or methyl; and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above are excluded.