Patent ID: 7049058
Filing Date: 2006-05-23
Classification: A61K,A61P,C12N,Y10S

Abstract:
1. A method for suppressing induction of inducible nitric oxide synthase in a cell compris said cell with an effective amount of at least one induction suppressor of either inducible nitric oxide synthase or a cytokine, wherein said induction suppressor is an inhibitor of mevalonate synthesis, an inhibitor of the farnesylation of Ras, an antioxidant wherein the antioxidant is N-acetyl cysteine (NAC), an enhancer of intracellular cAMP, an enhancer of protein kinase A (PKA), an inhibitor of Ras/Raf/MAP kinase pathway, an inhibitor of mevalonate pyrophosphate decarboxylase or an inhibitor of farnesyl pyrophosphate.