Patent ID: 6187772
Filing Date: 2001-02-13
Classification: A61P,C07D

Abstract:
A compound or a salt thereof represented by formula (I): ##STR50##whereinthe ring P is represented by the formula: ##STR51##in whichA represents an alkylene group, an alkenylene group or an alkynylene group, and Y is a group represented by the formula: ##STR52##in whichW represents CH, C= or a nitrogen atom; and,when W represents CH, m is 0 or 1, B represents an oxygen atom, a sulfur atom, a carbonyl group, a sulfinyl group, a sulfonyl group, an alkylene group, an alkenylene group, a group --C(OH)R.sub.1 -- in which R.sub.1 represents a substituted or unsubstituted aryl group, wherein the substituents are selected from the group consisting of alkyl groups having 1-4 carbon atoms and aryl groups having 6-14 carbon atoms, wherein said alkyl and aryl groups may be substituted with one or more of halogen atoms, alkoxy groups having 1-4 carbon atoms, hydroxyl groups, cyano groups and nitro groups, a group --CHR.sub.2 -- in which R.sub.2 represents a substituted or unsubstituted aryl group, wherein said group may be substituted with one or more of halogen atoms, alkoxy groups having 1-4 carbon atoms, hydroxyl groups, cyano groups and nitro groups, or a substituted or unsubstituted, cyclic or acyclic acetal group, wherein said group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms, aryl groups having from 6-14 carbon atoms, aralkyl groups having 7-22 carbon atoms and alkylidene groups having 1-4 carbon atoms;when W represents C=, m is 1, B is a group represented by the formula: ##STR53##in which the double bond is coupled with W and R.sub.3 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group, wherein the substituents are selected from the group consisting of one or more of halogen atoms, alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms and hydroxyl groups;when W represents a nitrogen atom, m is 0 or 1, and B represents a carbonyl group, a sulfonyl group, an alkylene group, an alkenylene group or a group --CHR.sub.4 -- in which R.sub.4 represents a substituted or unsubstituted aryl group, wherein said aryl group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms and alkoxy groups having 1-4 carbon atoms;E.sub.1 and E.sub.2 each independently represents a hydrogen atom or a lower alkyl group; andD represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, wherein said group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, aryl groups having 6-14 carbon atoms, aralkyl groups having 7-22 carbon atoms, aralkyloxy groups having 7-22 carbon atoms, cyano groups, nitro groups, carboxyl groups, alkoxycarbonyl groups, lower alkylsulfonylamino groups, carbamoyl groups and hydroxy groups;the dashed line indicates the presence or absence of a bond; and, when the bond indicated by the dashed line is present, Z.sub.2 is not present and Z.sub.1 represents a hydrogen atom but, when the bond indicated by the dashed line is absent, Z.sub.1 and Z.sub.2 both represent hydrogen atoms; Z.sub.1 represents a hydrogen atom and Z.sub.2 represents a hydroxyl group; Z.sub.1 and Z.sub.2 both represent groups SR.sub.5 in which R.sub.5 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted aryl group, wherein said group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms and alkoxy groups having 1-4 carbon atoms; Z.sub.1 and Z.sub.2 are combined together to represent an oxygen atom, a group NOR.sub.6 in which R.sub.6 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted aryl group, wherein said group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms and alkoxy groups having 1-4 carbon atoms, or a group represented by the formula: ##STR54##in whichG represents a substituted or unsubstituted ethylene group or a substituted or unsubstituted trimethylene group, wherein said group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms, aryl groups having 6-14 carbon atoms, aralkyl groups having 7-22 carbon atoms and alkylidene groups having 1-4 carbon atoms; andR represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl-alkyl group or a substituted or unsubstituted aralkyl group, wherein said aralkyl group may be substituted with one or more of halogen atoms, alkyl groups having 1-4 carbon atoms and alkoxy groups having 1-4 carbon atoms.