Patent ID: 6369077
Filing Date: 2002-04-09
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound according to formula (Ia): wherein:R1 is Râ€³, Râ€³C(O), Râ€³C(S), Râ€³SO2, Râ€³OC(O), Râ€³Râ€²NC(O), or Râ€³Râ€²NC(S); R2 is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R3 is H, C2-6alkenyl, C2-6alkynyl, Het, Ar or C1-6alkyl optionally substituted by ORâ€², SRâ€², NRâ€²2, N(Râ€²)C(O)ORâ€³, CO2Râ€², CO2NRâ€²2, N(C&boxH;NH)NH2, Het or Ar; R4 is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R5 is â€ƒAr-C0-6alkyl, Het-C0-6alkyl, adamantyl-C(O)â€”, Ar-C(O)â€”, or Het-C(O)â€”; R6 is Râ€³, Râ€³C(O), Râ€³C(S), Râ€³SO2, Râ€³OC(O), Râ€³Râ€²NC(O), Râ€³Râ€²NC(S),or Râ€³OC(O)NRâ€²CH(R*)C(O); R7 is C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, Ar-C0-6alkoxy, Het-C0-6alkoxy, or C1-6alkyl optionally substituted by ORâ€², SRâ€², NRâ€²2, N(Râ€²)C(O)ORâ€³, CO2Râ€², CO2NRâ€²2, N(C&boxH;NH)NH2, Het or Ar; R* is H, C1-6alkyl, C2-6alkenyl, C3-6cycloalkyl-C0-6-alkyl, Ar-C0-6alkyl, Het-C0-6alkyl; each Râ€² independently is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; each Râ€³ independently is C1-6alkyl, C3-6cycloalkyl-C0-6-alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; Râ€²â€³ is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; Z is C(O) or CH2; and n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.