Patent ID: 9060973
Filing Date: 2015-06-23
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant viral surface antigenic protein, wherein the viral surface antigenic protein in its native state forms a homotrimer on the surface of an enveloped virus, comprising an alpha-helix transmembrane domain, wherein three of the alpha-helix transmembrane domains of three molecules of the recombinant viral surface antigenic protein form a trimeric bundle, and wherein each of the alpha-helix transmembrane domains in the trimeric bundle contains at least one two-cysteine mini-domain selected from CxxC (SEQ ID NO 3), CxxxC (SE( )ID NO 4) and CxxxxC (SEQ ID NO 5), where x represents any amino acids as long as they do not break the helix structure; wherein when only one of the at least one two-cysteine minidomain (SEQ ID NO 4) is CFLLC that is present in transmembrane domain, native influenza A virus H3 HA is excluded.