Patent ID: 6071509
Filing Date: 2000-06-06
Classification: A61K,A61P,C12N

Abstract:
A method for providing activated natural killer (NK) cells comprising the steps of:administering to a population of cells which includes lymphocytes and monocytes, an effective amount of an NK cell activating cytokine, wherein said cytokine is selected from the group consisting of Interleukin-1 (IL-1), Interleukin-12 (IL-12) Interleukin-15 (IL-15), Interferon-.beta. (IFN-.beta.), and Interferon-.gamma. (IFN-.gamma.), or an NK cell activating flavonoid, wherein said NK cell activating flavonoid is selected from a group consisting of flavone-8-acetic acid (FAA) and xanthenone-4-acetic acid (XAA); andadministering histamine, other H.sub.2 -receptor agonist or serotonin.