Patent ID: 8865739
Filing Date: 2014-10-21
Classification: A61P,C07D

Abstract:
1. A method of treating a disease state in a human that is alleviable by treatment with an agent capable of reducing late sodium current, wherein the disease state is a cardiovascular disease selected from atrial arrhythmias, ventricular arrhythmias, heart failure, congestive heart failure, diastolic heart failure, systolic heart failure, acute heart failure, Prinzmetal's variant angina, stable angina, unstable angina, exercise induced angina, congestive heart disease, ischemia, recurrent ischemia, reperfusion injury, myocardial infarction, acute coronary syndrome, peripheral arterial disease, intermittent claudication, diabetes and diabetic peripheral neuropathy, comprising administering to said human in need thereof, a therapeutically effective dose of a compound of Formula (I): wherein: R R R R X is a covalent bond, cyano, —C(O)—, —C(O)O—, —CH(OH)—, or —C(O)NR Y is a covalent bond, alkylene of 1-6 carbon atoms, heterocyclyl, or heteroaryl; Z is a covalent bond, hydrogen, phenyl, benzyl, or cycloalkyl of 3-8 carbon atoms, all of which are optionally substituted by phenyl or heteroaryl, both of which are optionally substituted by 1, 2, or 3 substituents independently chosen from halo, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, and —C(O)R Z is phenyl optionally substituted by 1, 2, or 3 substituents independently chosen from halo, alkyl of 1-6 carbon atoms optionally substituted by heteroaryl, and alkoxy of 1-6 carbon atoms; with the proviso that X, Y and Z cannot all be covalent bonds; or a pharmaceutically acceptable salt, ester, prodrug, or solvate thereof.