Patent ID: 8124120
Filing Date: 2012-02-28
Classification: A61K,A61P

Abstract:
1. A method of augmenting tissue in a subject that is in need of tissue augmentation, the method comprising: a) inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with a crosslinked hyaluronic acid (HA) composition that includes crosslinked, water-insoluble, hydrated HA gel particles, wherein the HA includes crosslinks with represented by the following structural formula: wherein: each HA′ is the same or different crosslinked HA molecule; each U is independently an O-acyl isourea or N-acyl urea; and R wherein the HA gel particles have an average particle diameter distribution selected from the group consisting of a hydrated particle average diameter between about 20 μm and about 1000 μm, and a dehydrated particle average diameter between about 10 μm and about 500 μm; wherein the crosslinked HA composition is a single hydrated particle phase; and b) applying force to the syringe, whereby at least a portion of the crosslinked HA composition is delivered into the subject; wherein the crosslinked HA composition is stable in the subject for at least 8 weeks.