Patent ID: 7145005
Filing Date: 2006-12-05
Classification: C07D

Abstract:
1. A method of preparing crystalline 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one citrate, comprising the steps of: (a) dissolving 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one in a solution of citric acid and ethanol; (b) heating the reaction mixture to a temperature of about 40° C. to about 65° C.; (c) adding a seed slurry of 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one crystals; (d) cooling the resulting solution to less than 5° C. for at least one hour to provide a suspension; and (e) filtering the resulting suspension.