Patent ID: 8003097
Filing Date: 2011-08-23
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A method of restoring cerebral vascular phenotype in a patient suffering from vascular Aβ deposits, comprising administering an antibody that is specific for Aβ in a treatment regime associated with efficacious vascular amyloid removal, wherein the administration of the antibody restores cerebral vascular phenotype, wherein the antibody binds to an epitope within residues 1-10 of Aβ and the antibody is administered intravenously at a quarterly frequency at a dose of 0.5-1.5 mg/kg, or monthly at a dose of 0.1-1 mg/kg, or is administered subcutaneously at a frequency between weekly and monthly at a dose of between 0.01 mg/kg to 0.35 mg/kg and the antibody is administered at least for a year.