Patent ID: 6759386
Filing Date: 2004-07-06
Classification: A61K,G01N

Abstract:
A method for the systematic, multi-tiered treatment of coronary artery disease by delivey of a formulation comprising one or more therapeutic growth factor proteins, the method comprising the steps of:a.) selecting a patient displaying symptoms of acute coronary artery disease; b.) administrating at least one dose of an effective amount of a first therapeutic growth factor protein formulation comprising a growth factor protein being selected from the group consisting of FGF-1, FGF-2, VEGF, and mixtures thereof by inhalation therapy; c.) monitoring one or more clinical indicators of acute coronary artery disease; d.) determining, based on monitoring the one or more clinical indicators of coronary artery disease, whether an additional dose of a therapeutic growth factor protein formulation is neceasary; e.) depending on the results of the step d.), administering one or more additional doses of a second growth factor protein formulation comprising a growth factor protein being selected from the group consisting of FGF-1, FGF-2, VEGF, and mixtures thereof; and f.) repeating steps c.) through e.) until there is a clinical indication of amelioration of the symptoms of acute coronary artery disease in the patient, or until there is a contraindication to continued treatment.