Patent ID: 6743810
Filing Date: 2004-06-01
Classification: A61P,C07D

Abstract:
A compound of the formula I in whichA and B are each, independently of one another, O, S, NH, NR7, CO, CONH, NHCO or a direct bond, X is alkylene having 1 to 2 carbon atoms which is unsubstituted or monosubstituted by R4 or R5, or a direct bond, R1 is H, Z or â€”(CH2)oâ€”Ar, R2 is H, R7 or â€”C(O)Z, R3 is Het1, R4 and R5 are each, independently of one another, H, oxo, R7, â€”(CH2)oâ€”Ar, â€”C(O)â€”(CH2)oâ€”Ar, â€”C(O)â€”(CH2)oâ€”R7, â€”C(O)â€”(CH2)oâ€”Het, Het, NHR6, NHAr, NHâ€”Het, CONHâ€”R7, CONHâ€”(CH2)oâ€”Ar, CONHâ€”(CH2)oâ€”Het, OR7, OAr, OR6 or Oâ€”Het, R6 is H, â€”C(O)R7, â€”C(O)â€”Ar, â€”C(O)â€”Het, R7, COOR7, COOâ€”(CH2)oâ€”Ar, COOâ€”(CH2)oâ€”Het, SO2â€”Ar, SO2R7 or SO2â€”Het, R7 is alkyl having 1 to 10 carbon atoms or cycloalkyl having 3 to 10 carbon atoms, R8 is Hal, NO2, CN, Z, â€”(CH2)oâ€”Ar, COOR1, OR1, CF3, OCF3, SO2R1, NHR1, N(R1)2, NHâ€”C(O)R1, NHCOOR1, COOH, COOZ or C(O)R1, R9 is CN or NO2, Z is alkyl having 1 to 6 carbon atoms, Ar is aryl which is unsubstituted or monosubstituted or polysubstituted by R8, Hal is F, Cl, Br or I, Het is unsubstituted indol-2-yl, pyrrol-2-yl, pyridin-4-yl, thiophen-4-yl, thiazol-2-yl or benzothiadiazole, each of which Het1 is a pyridine, dihydropyridine or tetrahydropyridine, each of which may be unsubstituted or monosubstituted or disubstituted by Hal, R7, OR7, CN, NHZ, oxo or NO2, n is 0, 1 or 2, m is 0, 1, 2, 3, 4, 5 or 6, and o is 0, 1 or 2, and physiologically acceptable salts and solvates thereof.