Patent ID: 6486158
Filing Date: 2002-11-26
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinY1 and Y2 are independently selected from the group of (CH2)n, â€”C(X)â€”NHâ€”, â€”(CH2)nâ€”C(X)â€”Oâ€”, and X is O or S; R1 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, hydrogen, and substituted or unsubstituted phenyl, pyridinyl, pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolidinyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, morpholinyl, naphthyl, tetrazolyl, triazinyl, furfuryl and thiophenyl, wherein said substituents are one to three independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, nitro, cyano, carboxyl, lower alkyl mercapto, and lower alkyl sulfonyl; R2 is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolidinyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, tetrazolyl, morpholinyl, triazinyl, furfuryl and thiophenyl, wherein said substituents are one to three independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, nitro, cyano, carboxyl, aminosulfonyl, lower alkyl mercapto, and lower alkyl; A is a pyridine ring fused with the pyridazine ring; R3 is independently selected in each instance form the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, nitro, cyano, carboxyl, lower alkyl mercapto, and lower alkyl sulfonyl; m is an integer from 0 to 4; n is an integer from 0 to 3 p is 0 or 1; x is 0 to 2; and pharmaceutically acceptable salts thereof.