Patent ID: 7785891
Filing Date: 2010-08-31
Classification: A61P,G01N

Abstract:
1. A method of treating an aspirin non-responsive subject comprising: (i) identifying a subject as an aspirin non-responder, wherein an aspirin non-responder is a subject having an aspirin responsiveness of less than or equal to 50% of the value for aspirin responsiveness; by (a) perfusing a blood sample from a subject through a channel in a perfusion device, wherein the channel has a coating which produces a blood deposit when exposed to blood and wherein the perfusion device comprises a pump which draws the blood through the channel at a selected shear rate, producing a blood deposit; and (b) determining a status of aspirin responsiveness by measuring the level of blood deposited in the chamber and comparing the measured level of deposited blood with a control level of deposited blood, wherein said control level is selected from the group consisting of (1) a level measured using a sample of blood from said subject which has been treated with aspirin; (2) a level measured using a sample of blood from said subject which has been contacted with a thromboxane A2 receptor antagonist; and (3) a level previously determined to correspond to a status of aspirin responsiveness; wherein the perfusion device provides real time measurements of (1) the thrombotic profile of aspirin effects on top of P2Y (ii) administering to the aspirin non-responsive subject a thromboxane A2 receptor antagonist.