Patent ID: 6440723
Filing Date: 2002-08-27
Classification: C07B,C07H

Abstract:
An array comprising a plurality of modified oligonucleotide compositions stably associated with a surface of a support, comprising:a support comprised of a plurality of distinct areas on a surface of the support, said areas having a plurality of a first binding unit bound to the surface; and a plurality of different modified oligonucleotide compositions wherein each composition is characterized by an oligonucleotide backbone structure modified from that of a naturally occurring nucleotide polymer, wherein oligonucleotides of the compositions comprise a second binding unit which forms a non-covalent bond with said first binding unit and a blocking chemical modification at or near at least one end of each oligonucleotide; wherein each different modified oligonucleotide composition is stably associated with a different distinct area of the support, and further wherein modified oligonucleotides of each composition are characterized by a pH stability of at least one hour at 37Â° C. at a pH range of about 0.5 to about 6.0 and a nuclease resistance of at least twice that of a naturally occurring oligonucleotide having the same sequence and number of bases.