Patent ID: 6465618
Filing Date: 2002-10-15
Classification: C12N,C12Q,C12Y,G01N

Abstract:
A substantially pure human mitogen-activated protein kinase (MAPK) kinase, wherein said MAPK kinase has the following characteristics:(a) said MAPK kinase is activated by a stimulus induced by TNF-&agr; and/or by a stimulation of Fas antigen; (b) said MAPK kinase activates SAPK/JNK; and (c) said MAPK kinase does not activate p38; and (d) said MAPK kinase conserves fifteen amino acid residues which correspond to the following fifteen amino acid residues of SEQ ID NO:2: the 143rd Gly, the 145th Gly, the 150th Val, the 165th Lys, the 175th Glu, the 259th Asp, the 261st Lys, the 264th Asn, the 277th Asp, the 279th Gly, the 302nd Pro, the 303rd Glu, the 320th Asp, the 325th Gly and the 384th Arg.