Patent ID: 8097650
Filing Date: 2012-01-17
Classification: A61K,G01N

Abstract:
1. A method of treating an arrhythmia associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of a TREK-1 agonist effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the arrhythmia, wherein the TREK-1 agonist is a compound of the formula: or a pharmaceutically acceptable ester or salt thereof, wherein: R —C —C —O—(C —NH(C wherein each C each R3 is independently selected from the group consisting of halo, lower alkyl, lower alkoxy, NH2, NH—(lower alkyl), N(lower alkyl)2, NO2, CN, CF3, and; R4 is selected from the group consisting of H and lower alkyl; and n=0, m=0 to 2, and p=0 to 2.