Patent ID: 6350733
Filing Date: 2002-02-26
Classification: A61P,C07H

Abstract:
A compound selected from the group consisting of a compound of the formula wherein R1 is selected from the group consisting of a) hydrogen and â€”OH, b) alkyl, alkenyl and alkynyl of up to 12 carbon atoms optionally interrupted by a member of the group consisting of oxygen, sulfur and nitrogen and unsubstituted or substituted with at least one member of the group consisting of â€”OH, â€”CN, â€”NO2 and c) â€”CH2â€”pyridinyl and cycloalkyl of up to 12 carbon atoms, d) alkoxy of 1 to 8 carbon atoms unsubstituted or substituted with at least one member of the group consisting of halogen, â€”OH, â€”CN, â€”NO2 Ra and Rb are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing a second heteroatom selected from the group consisting of oxygen, sulfur and nitrogen, Rc and Rd are individually selected from the group consisting of hydrogen and alkyl of 1 to 12 carbon atoms optionally interrupted by a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally substituted by at least one member of the group consisting of halogen, â€”OH, â€”CN2 and â€”NO2 or taken together with the nitrogen form a heterocycle optionally containing a second heteroatom selected from the group consisting of oxygen, sulfur and nitrogen, X is selected from the group consisting of oxygen, &boxH;N-Nalk1 and &boxH;NOalk2, alk1 and alk2 are individually alkyl of up to 12 carbon atoms optionally interrupted with an oxygen, sulfur or nitrogen and optionally substituted by at least one halogen or Re and Rf are individually hydrogen or alkyl of 1 to 8 carbon atoms optionally substituted by at least one member of the group consisting of halogen, â€”OH, â€”CN and â€”NO2 or taken together with the nitrogen form a heterocycle optionally containing a second heteroatom selected from the group consisting of oxygen, sulfur and nitrogen, R2 is hydrogen or halogen, R3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, R4 is selected from the group consisting of aryl and heteroaryl with the latter two optionally substituted by at least one member of the group consisting of halogen, â€”OH and alkyl and alkoxy of up to 8 carbon atoms, Rg and Rh are individually selected from the group consisting of hydrogen, alkyl and cycloalkyl of up to 8 carbon atoms, aryl and heteroaryl, the latter two optionally substituted with at least one member of the group consisting of halogen, â€”OH and alkyl and alkoxy of 1 to 8 carbon atoms, R5 is hydrogen or alkoxy of 1 to 4 carbon atoms, R6 is alkyl or â€”CH2â€”O-alkyl of up to 8 carbon atoms, R7 is hydrogen or alkyl of 1 to 8 carbon atoms and a salt thereof of a pharmaceutically acceptable base or acid.