Patent ID: 7169564
Filing Date: 2007-01-30
Classification: G01N

Abstract:
1. A method for identifying a compound that modulates interactions between FKBP51, hsp90, and a binding partner selected from the group consisting of hairless, AFX-1, gli3, and a combination thereof, comprising: (i) contacting a cell that expresses, or a preparation comprising FKBP51, hsp90, and the binding partner with a test compound; (ii) determining the level of complex formation between FKBP51, hsp90, and the binding partner in the cell or the preparation contacted with the test compound; and (iii) comparing the level of complex formation obtained in (ii) to the level of complex formation between FKBP51, hsp90, and the binding partner in the cell or the preparation in the absence of the test compound; wherein a difference in the level of complex formation in the presence versus in the absence of the test compound indicates that the test compound is capable of modulating interactions between FKBP51 hsp90, and the binding partner.