Patent ID: 6459000
Filing Date: 2002-10-01
Classification: C07C,Y02P

Abstract:
A liquid phase process for the acylation of aromatic compound of the formula (R1R2R3R4)â€”Mâ€”H by an acylating agent of the formula (R5R6R7)â€”Yâ€”Z to obtain the corresponding acylated compound of the formula (R1R2R3R4)â€”Mâ€”Yâ€”(R5R6R7), wherein M is an aromatic nucleus with R1R2R3, and R4 being the chemical groups attached thereto, Y is the nucleus of the acylating agent and is selected from the group consisting of Câ€”CO, CnH2nâˆ’2CO, C6H2CO, C6H2CnH2nâ€”CO and C6H2CnH2nâˆ’1(X)â€”CO with R5, R6 and R7 being chemical groups attached thereto Y, Z is selected from the group consisting of Cl, Br, I and OH, X is a halogen, and n is an integer having a value equal to or greater than 1.0, using a solid catalyst comprising a metal oxide of the formula AOx with or without a catalyst support, wherein A is a metallic element selected from Ga, In, Tl, Fe and a mixture of two or more thereof, and x is the number of oxygen atoms required to fulfil the valance requirement of A, the said process comprising,i. pretreating the solid catalyst by contacting it with a dry gas comprising a hydrogen halide in the presence or absence of the aromatic compound to be acylated; ii. contacting the hydrogen halide pretreated catalyst with a liquid reaction mixture comprising the aromatic compound and the acylating agent in a stirred batch reactor at following reaction conditions: weight ratio of catalyst to acylating agent in the range of about 0.01 to about 2.0, mole ratio of the aromatic compound to the acylating agent in the range of from about 0.1 to 100, weight ratio of non-aqueous solvent to the aromatic compound being in the range of about 0 to about 100, reaction temperature being in the range of about 10Â° C. to about 300Â° C., pressure in the range of about 0.5 atm to about 10 atm., gas hourly space velocity of inert gas bubbled through the reaction mixture being in the range of about 0 hâˆ’1 to 5000 hâˆ’1 and reaction period in the range of from about 0.02 hours to about 100 hours; iii. cooling the reaction mixture to a temperature of about 30Â° C., removing the catalyst from the reaction mixture by filtration and then separating the reaction products from the reaction mixture.