Patent ID: 7579451
Filing Date: 2009-08-25
Classification: A61K,C07F,C07H,Y02A

Abstract:
1. A single-stranded RNAi agent represented by formula I: wherein: X is H, —P(O)(OM) M represents independently for each occurrence an alkali metal or a transition metal with an overall charge of +1; n is 16, 17, 18, 19, 20, 21, 22, 23, or 24; A A R R R R R R R R R R R R m represents independently for each occurrence 1, 2, 3, 4, 5, 6, 7, or 8; v represents independently for each occurrence 1, 2, 3, or 4; w Z Z A A wherein Y 1 represents independently for each occurrence N or CR 50 , Y 2 represents independently for each occurrence NR 50 , O, S, or Se; w 2 represents independently for each occurrence 0, 1, 2, or 3; R 50 represents independently for each occurrence H, alkyl, aryl, or aralkyl; and R 51 represents independently for each occurrence H, halogen, hydroxyl amino, dialkylamino, alkoxyl, alkyl, aryl, or aralkyl; A R