Patent ID: 6337346
Filing Date: 2002-01-08
Classification: A61P,C07D

Abstract:
A method for inhibiting cellular mitosis in a tumor cell, said method comprising contacting a tumor cell with a compound in an amount effective to inhibit cellular mitosis therein, said compound selected from the group consisting of compounds of Formula I and compounds of Formula II: wherein:R1, R2, R3 and R4 are each independently selected from the group consisting of: hydrogen alkyl carboxy, alkoxy, hydroxyalkyl, alkylcarbonyl; alkylcarbonyloxy; alkyl substituted with alkylcarbonyloxy, thiophenylcarbonyl; nitro and cyano; thiophenyl and thiophenylthiophenyl, each of which may be unsubstituted or substituted with alkyl, carboxy, alkoxy, hydroxyalkyl, alkylcarbonyl; alkylcarbonyloxy; alkyl substituted with alkylcarbonyloxy, nitro or cyano; subject to the proviso that at least one of R1, R2, R3 and R4 is not hydrogen; A1 and A2 are each selected from the group consisting of &boxH;O, alkyl, alkoxy, and alkylcarbonyloxy; and the pharmaceutically acceptable salts thereof.