Patent ID: 6355798
Filing Date: 2002-03-12
Classification: A61P,C07D

Abstract:
A compound of formula I, or a salt thereof: whereinY represents hydrogen or C1-6alkyl; Z represents C1-6alkyl, C3-7cycloalkyl, C4-7cycloalkenyl, aryl, or di(C1-6)alkylamino, any of which groups may be optionally substituted by one or two substituents independently being C1-6alkyl, phenyl(C1-6)alkyl, naphthyl(C1-6)alkyl, pyridyl(C1-6)alkyl, halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, oxo, hydroxy, hydroxymethyl, C1-6alkoxy, C3-7cycloalkyl(C1-6)alkoxy, C3-7cycloalkoxy, amino, C1-6alkylamino, di(C1-6)alkylamino, amino(C1-6)alkyl, di(C1-6)alkylamino(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, N-(C1-6)alkylpiperidinyl, pyrrolidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, di(C1-6)alkylmorpholinyl(C1-6)alkyl or imidazolyl(C1-6)alkyl; R1 represents C3-7cycloalkyl, phenyl, furyl, thienyl or pyridinyl, any of which groups may be optionally substituted by one or two substituents independently being C1-6alkyl, phenyl(C1-6)alkyl, naphthyl(C1-6)alkyl, pyridyl(C1-6)alkyl, halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, oxo, hydroxy, hydroxymethyl, C1-6alkoxy, C3-7cycloalkyl(C1-6)alkoxy, C3-7cycloalkoxy, amino, C1-6alkylamino, di(C1-6)alkylamino, amino(C1-6)alkyl, di(C1-6)alkylamino(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, N-(C1-6)alkylpiperidinyl, pyrrolidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, di(C1-6)alkylmorpholinyl(C1-6)alkyl or imidazolyl(C1-6)alkyl; R2 represents hydrogen or C1-6alkyl; and R3 represents hydrogen or C1-6alkyl, C3-7cycloalkyl(C1-6)alkyl, propargyl, aryl(C1-6)alkyl, azetidinyl(C1-6)alkyl, pyrrolidinyl(C1-6)alkyl, piperidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, thiomorpholinyl(C1-6)alkyl, pyridinyl(C1-6)alkyl, quinolinyl(C1-6)alkyl, isoquinolinyl(C1-6)alkyl, pyridazinyl(C1-6)alkyl, pyrimidinyl(C1-6)alkyl, pyrazinyl(C1-6)alkyl, quinoxalinyl(C1-6)alkyl, furyl(C1-6)alkyl, benzofuryl(C1-6)alkyl, dibenzofuryl(C1-6)alkyl, thienyl(C1-6)alkyl, benzthienyl(C1-6)alkyl, pyrrolyl(C1-6)alkyl, indolyl(C1-6)alkyl, pyrazolyl(C1-6)alkyl, indazolyl(C1-6)alkyl, oxazolyl(C1-6)alkyl, isoxazolyl(C1-6)alkyl, thiazolyl(C1-6)alkyl, isothiazolyl(C1-6)alkyl, imidazolyl(C1-6)alkyl, benzimidazolyl(C1-6)alkyl, oxadiazolyl(C1-6)alkyl, thiadiazolyl(C1-6)alkyl, triazolyl(C1-6)alkyl, or tetrazolyl(C1-6)alkyl, any of which groups may be optionally substituted by one or two substituents independently being C1-6alkyl, phenyl(C1-6)alkyl, naphthyl(C1-6)alkyl, pyridyl(C1-6)alkyl, halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, oxo, hydroxy, hydroxymethyl, C1-6alkoxy, C3-7cycloalkyl(C1-6)alkoxy, C3-7cycloalkoxy, amino, C1-6alkylamino, di(C1-6)alkylamino, amino(C1-6)alkyl, di(C1-6)alkylamino(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, N-(C1-6)alkylpiperidinyl, pyrrolidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, di(C1-6)alkylmorpholinyl(C1-6)alkyl or imidazolyl(C1-6)alkyl.