Patent ID: 6093723
Filing Date: 2000-07-25
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I): ##STR8## wherein: Q is selected from the group consisting of N--R.sub.2, O or S;n is an integer selected from the group consisting of 0, 1, 2, 3 and 4;R is selected from the group consisting of C.sub.2 -C.sub.6 branched or unbranched alkynyl, NR.sub.3 R.sub.4, phenyl substituted with one or more independently selected R.sub.1, naphthyl optionally substituted with one or more independently selected R.sub.1 and heterocycles selected from the group consisting of benzimidazolyl, imidazolyl, imidazolinoyl, imidazolidinyl, quinolyl, isoquinolyl, indolyl, oxadiazolyl, pyridyl, pyrrolyl, pyrazolyl, pyrazinyl, quinoxolyl, piperidinyl, morpholinyl, thiamorpholinyl, thienyl, triazolyl, thiazolyl, .beta.-carbolinyl, tetrazolyl, thiazolidinyl, benzofuranoyl, thiamorpholinyl sulfone, benzoxazolyl, oxopiperidinyl, oxopyrroldinyl, oxoazepinyl, azepinyl, isoxazolyl, tetrahydropyranyl, tetrahydrofuranyl, thiadiazolyl, benzodioxolyl, tetrahydrothiophenyl and sulfolanyl each optionally substituted with one or more independently selected R.sub.1 ;R' and R"" are independently selected from the group consisting of H, halo and C.sub.1 -C.sub.3 alkyl;each R.sub.1 is independently selected from the group consisting of OH, nitro, NR.sub.3 R.sub.4, COR.sub.4, CO.sub.2 R.sub.4, cyano, halo, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, C.sub.1 -C.sub.6 branched or unbranched alkyl, C.sub.2 -C.sub.6 branched or unbranched alkenyl, C.sub.2 -C.sub.6 branched or unbranched alkynyl, C.sub.1 -C.sub.6 branched or unbranched alkoxy, wherein said cycloalkyl, cycloalkenyl, alkyl, alkenyl, alkynyl or alkoxy may be optionally substituted with one to three substituents (the same or different) independently selected from the group consisting of OH, NR.sub.3 R.sub.4, COR.sub.4, CO.sub.2 R.sub.4, cyano and halo;R.sub.2 is selected from the group consisting of H, an amino protecting group, C.sub.1 -C.sub.6 branched or unbranched alkyl, C.sub.2 -C.sub.6 branched or unbranched alkenyl, C.sub.2 -C.sub.6 branched or unbranched alkynyl and benzyl;each R.sub.3 is independently selected from the group consisting of H, C.sub.1 -C.sub.6 branched or unbranched alkyl; C.sub.2 -C.sub.6 branched or unbranched alkenyl, C.sub.2 -C.sub.6 branched or unbranched alkynyl, C.sub.1 -C.sub.6 branched or unbranched alkoxy, phenyl and benzyl; andeach R.sub.4 is independently selected from the group consisting of H, phenyl and C.sub.1 -C.sub.6 branched and unbranched alkyl optionally substituted with phenyl with the proviso that R excludes o-methylphenyl, m-methylphenyl, methoxyphenyl, methylpyridinyl, 1-benzylimidazol-2-yl, N-methyl-piperidin-2-yl, 1-methyl-imidazolyl-2-yl and amino.