Patent ID: 6271238
Filing Date: 2001-08-07
Classification: A61P,C07D,Y02P

Abstract:
Novel acetamide compounds represented by the following chemical formula (I) or pharmacologically acceptable salts thereof: ##STR71##wherein R.sup.0 is a phenyl group whose ring may have one or more substituent groups selected from group A defined below (group A; group A represents halogen, nitro, a hydroxyl group, a lower alkoxy group, a lower alkyl group, or a halogen-substituted lower alkyl group);R.sup.1 is (i) aryl or (ii) heteroaryl which may independently have one or more substituent groups defined with respect to group A; or R.sup.1 may independently have one or more substituent groups selected from OH, COOH, NH.sub.2, CONH.sub.2, NHCHO and group B consisting of OR.sub.a, COOR.sub.a, CONR.sub.b R.sub.c, NR.sub.b R.sub.c, NR.sub.b CHO and NR.sub.b COR.sub.a on the above groups (i) or (ii) (among which R.sub.a to R.sub.c are independently lower alkyl or substituted lower alkyl; or R.sub.a to R.sub.c are independently aryl (1-7C) alkyl, heteroaryl (1-7C) alkyl, aryl and heteroaryl, among which the aryl or heteroaryl ring may have one or more, usually 1 to 3, substituent groups selected from the above-defined group A; the substituted lower alkyl has 1 to 3 atoms or groups selected from halogen and nitro group as substituent group; or R.sup.1 may have one or more of the following defined cyclic group G on the above groups (i) or (ii) (cyclic group G; cyclic group G represents a heterocyclic group consisting of a 5- or 6-membered ring containing 1 to 3 oxygen or nitrogen atoms and may have a substituent group);R.sup.2 represents (1-8C) alkyl, aryl (1-7C) alkyl, heteroaryl (1-7C) alkyl, and aryl; or R.sup.2 represents OH, NH.sub.2, NHCHO, the above-defined group B or (1-8C) alkyl having group B as a substituent group; or (1-8C) alkyl having the above-defined cyclic group G as a substituent group;R.sup.3 is hydrogen; or R.sup.3 is (i) D(CH.sub.2).sub.0-3 CO, (ii) DCOECO or (iii) DSO.sub.2 ECO as an acyl group; or R.sup.3 is D(CH.sub.2).sub.0-3 SO.sub.2 or DCOESO.sub.2 as a sulfonyl group (wherein group D represents hydrogen, a C1-6 straight-chain, branched or cyclic alkyl group, aryl group, halogeno lower alkyl, halogeno lower alkoxy, lower alkoxyamino, halogeno lower alkylamino, R.sub.b R.sub.c N, R.sub.b R.sub.c NO, R.sub.a O, R.sub.a, R.sub.a OCO, R.sub.b R.sub.c NCO, R.sub.a SO.sub.2 NR.sub.b, R.sub.a S and the above-defined group G; and group E represents a divalent crosslinking group containing 1 to 6 carbon atoms); or R.sup.3 is thiourea represented by R.sub.b R.sub.c NCS; or R.sup.3 is R.sub.a ;X represents a carbon atom, which may be substituted by groups represented by R.sub.a to R.sub.c, and Y represents a nitrogen atom; andZ represents a polymethylene group wherein hydrogen atoms on the polymethylene group may independently be replaced by R.sub.a and R.sub.b.