Patent ID: 8912228
Filing Date: 2014-12-16
Classification: A61K

Abstract:
1. A sterile pharmaceutical formulation for use in treatment of a patient in need thereof, comprising: (a) docetaxel, or a pharmaceutically acceptable salt thereof; (b) a solubilizer selected from the group consisting of ethanol, glycofurol, and mixtures thereof; (c) d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS 1000); (d) one or more hydrotropes, wherein the one or more hydrotropes are selected from the group consisting of polyethylene glycol, propylene glycol, acetic acid, and a combination thereof; (e) one or more agents having a pK (f) α-lipoic acid, or a pharmaceutically acceptable salt thereof, in an amount of about 0.1 mg/mL to about 5 mg/mL; wherein the formulation is substantially free of polysorbates and polyethoxylated castor oil.