Patent ID: 9192584
Filing Date: 2015-11-24
Classification: A61K,A61P

Abstract:
1. A process for preparing a substantially solvent-free composition comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, said water-soluble carrier material comprising a water-soluble polymer selected from the group consisting of polyvinylalcohol, polyethylene glycol, polyvinylpyrrolidone, poly(2-ethyl-2-oxazaline), hydroxypropylcellulose, hydroxypropylmethylcellulose, alginates, and mixtures thereof, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form, said process comprising: (a) forming an emulsion comprising: (i) a solution of the water-insoluble antiviral drug in a water-immiscible solvent, where the water-immiscible solvent is selected from the group consisting of chloroform, toluene, cyclohexane, ethyl acetate, dichloromethane, and mixtures thereof, and (ii) a solution of the water-soluble carrier material in an aqueous solvent, and, (b) spray-drying or freeze-drying the emulsion or single phase solution to remove the aqueous solvent and the water-immiscible solvent to obtain the substantially solvent-free composition comprising a nano-dispersion of the antiviral drug in the carrier material.