Patent ID: 7166593
Filing Date: 2007-01-23
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula I an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug; wherein m is 1 or 2; --- represents an optional bond; D is CR E is C or CR F is CR R Z for each occurrence is independently a) —(C R R provided that one of R R or R R or R R R or R R or R or R R R R or R or R aryl is a) phenyl substituted with 0 to 3 R het is a 5-,6- or 7-membered saturated, partially saturated or unsaturated ring containing from one (1) to three (3) heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur; and including any bicyclic group in which any of the above heterocyclic rings is fused to a benzene ring or another heterocycle; and the nitrogen may be in the oxidized state giving the N-oxide form; and substituted with 0 to 3 R R aryl′ is phenyl, naphthyl or biphenyl; het′ is a 5-,6- or 7-membered saturated, partially saturated or unsaturated ring containing from one (1) to three (3) heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur; and including any bicyclic group in which any of the above heterocyclic rings is fused to a benzene ring or another heterocycle; provided that: 1) when R 2) when R when R 2 is hydroxy, R 3 is hydrogen and R 9 is hydrogen on the A-ring, then R 10 is other than —O—(C 1 –C 6 )alkyl or —O—CH 2 -phenyl at the 2-position of the A-ring.