Patent ID: 9060986
Filing Date: 2015-06-23
Classification: A61K,A61P

Abstract:
1. A delivery system for sustained release of nicardipine free base, a hydrate or solvate thereof, adapted for introduction into the cerebrospinal fluid of a subject, comprising a solid dispersion product of nicardipine free base, hydrate or solvate thereof, in a mixture of: (i) a first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn (ii) a second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn wherein: Mn the nicardipine free base, hydrate or solvate thereof is molecularly dispersed in a monophasic mixture comprising the first poly(lactide-co-glycolide) and the second poly(lactide-co-glycolide); and the solid dispersion product is formed into a predetermined shape prior to introduction into the cerebrospinal fluid of said subject.