Patent ID: 6344465
Filing Date: 2002-02-05
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating an IMPDH mediated disease selected from the group consisting of transplant rejection, autoimmune diseases, multiple sclerosis, juvenile diabetes, asthma, inflammatory diseases, lymphoma or leukemia, and hyperproliferative vascular diseases, by inhibiting the IMPDH enzyme in a mammal said method comprising the step of administering to said mammal a composition comprising a compound selected from Table IC below:TABLE IC Compound #L116NHC(O)O-t-butyl117NCH3C(O)O-t-butyl118NHC(O)O-methyl119NHC(O)O-phenyl120NHC(O)O-(S)-3-tetrahydrofuranyl121NHC(O)O-2-picolinyl122NHC(O)O-(S)-5-oxazolidinonylmethyl123NHC(O)O-4-carbomethoxyphenyl124NHC(O)O-isobutyl125NHC(O)O-allyl126NHC(O)O-5-(1,3-dioxanyl)127NHC(O)O-4-acetamidophenyl128NHC(O)O-2-furfuryl129NHC(O)O-2-thiofurfuryl130NHC(O)O-2-methoxyethyl131NHC(O)O-4-tetrahydropyranyl132NHC(O)O-cyclohexyl133NHC(O)O-cyclopentyl134NHC(O)O-2-hydroxyethyl135NHC(O)O-cyclohexylmethyl136NHC(O)O-(R,S)-3-tetrahydrofuranyl137NHC(O)O-3-pyridyl138NHC(O)O-benzyl139NHC(O)O-3-(tBOC-amino)propyl140NHC(O)O-4-hydroxybutyl141NHC(O)O-5-hydroxypentyl142NHC(O)O-(R,S)-2-pyranyl143NHC(O)O-3-(N-tBOC)-piperidinyl144NHC(O)O-(R)-3-(2-oxo-4,4-dimethyl)furanyl145NHC(O)O-3-methylthiopropyl146NHC(O)O-4-[(2,2-dimethyl)-1,3-dioxanyl]methyl147NHC(O)O-2-di-(hydroxymethyl)ethyl148NHC(O)O-4-(N-tBOC)-piperidinylmethyl149NHC(O)O-3-(N-tBOC)-piperidinylmethyl150NHC(O)O-(dibenzyloxymethyl)methyl151NHC(O)O-di-(hydroxymethyl)methyl152NHC(O)O-2-(N-tBOC)-piperidinylmethyl153NHC(O)O-3-piperidinyl-TFA154NHC(O)O-(R,S)-(2-tetrahydropyranyl)methyl155NHC(O)O-4-piperidinylmethyl-TFA156NHC(O)O-(R,S)-tetrahydrofuranylmethyl157NHC(O)O-3-methylsulfonylpropyl158NHC(O)O-3-piperidinylmethyl-TFA159NHC(O)O-2-piperidinylmethyl-TFA160NHC(O)O-(R,S)-3-tetrahydrothiophenyl161NHC(O)O-(R,S)-3-tetrahydrothiopyranyl162NHC(O)O-3-methoxypropyl