Patent ID: 7718128
Filing Date: 2010-05-18
Classification: B01D,B01J,B82Y,C07D,C07K

Abstract:
1. A sensor chip comprising a compound of formula (1) below bound to a first material and a ligand bound to a second material, wherein one of the first and second materials is a solid phase, and the other is selected from the group consisting of an enzyme including histidine, cystein, or tryptophane, a substrate, a substrate analogue, a suppressor, a coenzyme, an antibody, an antigen, a virus, cell lectin, a polysaccharide, a glucoprotein, a cell surface receptor, a nucleic acid, a complementary base sequence, histone, a nucleic acid polymerase, a nucleic acid binding protein, ATP, ADP, a hormone, a vitamine, a receptor, a carrier protein, glutathione, a GST fusion protein, a metallic ion, a polyHIS fusion protein, a natural protein, and a combination thereof, where n is an integer from 6 to 10; X is O, S or NH; each of A1 and A2 is independently H, OR, SR, or NHR, and A1 and A2 are not simultaneously H, where R is selected from the group consisting of H; a substituted or non-substituted C1-C30 alkyl group; a substituted or non-substituted C2-C30 alkenyl group; a substituted or non-substituted C2-C30 alkynyl group; a substituted or non-substituted C2-C30 carbonylalkyl group; a substituted or non-substituted C1-C30 thioalkyl group; a substituted or non-substituted C1-C30 alkylthiol group; a substituted or non-substituted C1-C30 hydroxyalkyl group; a substituted or non-substituted C1-C30 alkylsilyl group; a substituted or non-substituted C1-C30 aminoalkyl group; a substituted or non-substituted C1-C30 aminoalkylthioalkyl group; a substituted or non-substituted C5-C30 cycloalkyl group; a substituted or non-substituted C2-C30 heterocycloalkyl group; a substituted or non-substituted C6-C30 aryl group; a substituted or non-substituted C6-C30 arylalkyl group; a substituted or non-substituted C4-C30 heteroaryl group; and a substituted or non-substituted C4-C30 heteroarylalkyl group.