Patent ID: 7198776
Filing Date: 2007-04-03
Classification: A61K

Abstract:
1. A metal complex compound comprising a paramagnetic chelate comprising a paramagnetic metal ion M and a chelating agent, said chelating agent is a chelating agent according to formula (I) wherein R A and B are the same or different and represent CHR Z represents NH X represents a molecular moiety whose coordination distance to the paramagnetic metal ion chelated by the chelating agent of formula (I) changes upon influence of enzyme activity, being selected from the group of; Y represents a fluorine atom or a hydrocarbon group comprising at least one fluorine atom, D represents a saturated or unsaturated straight or branched-chain hydrocarbon group containing 1 to 4 carbon atoms or a phenyl group, m represents an integer from 2 to 3 and n and o are the same or different and represent an integer from 1 to 3, wherein the coordination distance between X and M changes upon influence of enzymatic activity and thereby changing the chemical shift of the at least one fluorine atom.