Patent ID: 6734191
Filing Date: 2004-05-11
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of the formula and the salts and prodrug forms thereofwherein the dotted lines represent optional unsaturation; R1 is a non-interferein substituent selected from halo, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted thiol, and substituted or unsubstituted acyl; R2 and R3 are independently H or non-interfering substituents selected from halo, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted thiol, and subsituted or unsubstituted acyl, or R2 and R3 may together form a benzo ring; k is 0-3; each n is independently 0-1; each R is independently H or alkyl (1-6C); j is 0-3; and each Y is independently, non-interfering substituent selected from the group consisting of halo, OR; SH; SO; SO2; optionally substituted phenyl; (CR2)mOR; (CR2)mCOR; (CR2)mCOOR; (CR2)mN&boxH;CHâ€”NR2; (CR2)mCN; (CR2)mNR52; (CR2)mNR(CR2)mNRR4; (CR2)mNR(CR2)mNR(CR2)mNR52; (CR2)mCO(CR2)mNR52; (CR2mCO(CR2)mNR(CR2)mNRR4; (CR2)mCO(CR2)mNR(CR2)mNR(CR2)mNR52; (CR2)mNRCO(CR2mNRR4; (CR2)mNRCO(CR2)mNR(CR2)mNR52; (CR2)mNRCO(CR2)mNR(CR2)mNR(CR2)mNR(CR2)mNR52; (CR2)mNROH; (CR2mCONROH; (CR2)mCR&boxH;NOH; (CR2)m guanidino; (CR2)mCONHNHR; and (CR2)m amidino; wherein R is H or alkyl (1-6C), each m is independently 0-4, and each R4 and each R5 is independently H, alkyl (1-6C), alkenyl (1-6C), alkynyl (1-bC), or acyl (1-6C), eahc optionally substituted by one or more nonaromatic, nonheterocyclic substitutent(s).