Patent ID: 8303977
Filing Date: 2012-11-06
Classification: A61K,A61M,Y10T

Abstract:
1. A method of delivering one or more active ingredients to a subject, comprising: implanting an implantable device into the subject, in which the implantable device comprises a polyurethane-based polymer having polycarbonate-based polyol segments represented by the formula: whereby an increase in “n” represents a decrease in Flex Modulus, said polyurethane-based polymer configured to provide a cylindrically shaped reservoir, wherein the reservoir is sealed after being charged with an effective amount of a solid formulation comprising one or more active ingredients exhibiting hydrophobic characteristics, such that the release of the one or more active ingredients at a substantially zero order rate in vitro by diffusion through the polyurethane-based polymer generally increases with the selection of polyurethane-based polymers of decreasing Flex Modulus.