Patent ID: 9066918
Filing Date: 2015-06-30
Classification: A61K,A61P

Abstract:
1. A method to improve the efficacy and/or reduce the side effects of suboptimally administered drug therapy comprising the steps of: (a) identifying at least one factor or parameter associated with the efficacy and/or occurrence of side effects of the drug therapy; and (b) modifying the factor or parameter to improve the efficacy and/or reduce the side effects of the drug therapy; wherein the suboptimally administered drug therapy comprises administration of a substituted hexitol and wherein the substituted hexitol is selected from the group consisting of dianhydrogalactitol and diacetyldianhydrogalactitol; and wherein the factor or parameter is selected from the group consisting of: (a) route of administration; (b) schedule of administration; (c) indications for use; (d) selection of disease stage; (e) other indications; (f) patient selection; (g) patient/disease phenotype; (h) patient/disease genotype; (i) pre/post-treatment preparation; (j) toxicity management; (k) drug combinations; (l) post-treatment patient management; (m) drug delivery systems; (n) drug conjugate forms; (o) prodrugs; (p) multiple drug systems; (q) novel mechanisms of action; and (r) selective target cell population therapeutics.