Patent ID: 6183776
Filing Date: 2001-02-06
Classification: A61K,A61P

Abstract:
An oral pharmaceutical composition comprising, as a first component, an acid susceptible proton pump inhibitor, and as a separate second component, at least one substance selected from the group consisting of antacid agents, alginates and mixtures thereof, and as an optional third component, pharmaceutically acceptable excipients, wherein:(a) the composition is in the form of a multiple unit tablet;(b) the first component is in the form of pellets covered with an enteric coating layer,(c) the second component is separated from the first component by the enteric coating layer covering the first component; and(d) the enteric coating layer has mechanical properties such that the acid resistance of the enteric coated pellets is not significantly affected by compression of the pellets with the other tablet components during tableting.