Patent ID: 8759307
Filing Date: 2014-06-24
Classification: C07H,C07K,C12N

Abstract:
1. An antisense compound, which is composed of morpholino subunits and phosphorus-containing intersubunit linkages, which join a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, for use in inhibiting replication of a nidovirus in mammalian host cells, comprising: (i) a nuclease-resistant backbone, (ii) 12-25 nucleotide bases, and (iii) a targeting sequence that is complementary to at least 12 contiguous bases contained in SEQ ID NO: 3; wherein the targeting sequence forms a heteroduplex structure composed of SEQ ID NO: 3 and the antisense compound, SEQ ID NO:3 comprising a transcriptional regulatory sequence in a 5′ leader region of a positive-strand viral genome, the heteroduplex structure characterized by a T