Patent ID: 6306863
Filing Date: 2001-10-23
Classification: A61P,C07D

Abstract:
A method of treating asthma in a patient in need of such treatment, said method comprising the step of administering to said patient a therapeutically effective amount of a compound of formula (I) ##STR37##wherein--W represents --CH.sub.2 -- or a bond; Q represents an aryl group Ar.sup.1 or Ar.sup.2 ; in the case where W represents --CH.sub.2 --, Q represents Ar.sup.1 wherein Ar.sup.1 represents naphthyl, phenyl, quinolyl, isoquinolyl, indolyl, benzofuranyl or benzothienyl; in the case where W represents a bond, Q represents an aryl group Ar.sup.2 wherein Ar.sup.2 represents acenaphthenyl, fluorenyl or indanyl; wherein the ring systems which Ar.sup.1 and Ar.sup.2 represent may all be optionally substituted by one or more substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, or trifluoromethyl; R.sup.10 represents X--(A).sub.p --Y; X represents S(O).sub.n, C.ident.C, (CH.sub.2).sub.2, CH.dbd.CH or CH.sub.2 CH.dbd.CH; n represents 0, 1 or 2; A represents C.sub.1-6 alkylene; p is 0 or 1; Y represents CN, OR.sup.11, CO.sub.2 R.sup.12, CONR.sup.13 R.sup.14, NR.sup.15 R.sup.16, NHSO.sub.2 R.sup.17, NHCOR.sup.18 or an optionally substituted aryl or heteroaryl group, provided that when X represents S(O).sub.n and Y is other than an optionally substituted aryl or heteroaryl group, then p is 1 and also provided that when X represents S(O).sub.n, p is 1 and Y represents OH, then n is not 0; R.sup.13 and R.sup.14 independently represent H, C.sub.1-5 alkyl or phenyl, which latter group may be substituted by one or more substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, or CO.sub.2 R.sup.21 ; and R.sup.1, R.sup.2, R.sup.11, R.sup.12, R.sup.15, R.sup.16, R.sup.17, R.sup.18 and R.sup.21 independently represent H or C.sub.1-5 alkyl; or a pharmaceutically acceptable derivative thereof.