Patent ID: 9078844
Filing Date: 2015-07-14
Classification: A61K,A61P,Y02A

Abstract:
1. A Th1 immune response-eliciting combination comprising a first constituent, wherein the first constituent is a bacterial cell active as an adjuvant which comprises at least one recombinant nucleic acid molecule encoding a Listeria phagolysosomal escape peptide or a Listeria phagolysosomal escape polypeptide, wherein the bacterial cell is a urease-deficient Mycobacterium cell and a separate second constituent, wherein the second constituent is an immune response-eliciting biologically active agent selected from the group consisting of a tumor-specific antigen, a tumor-associated antigen, a virus antigen, a bacterial antigen, a parasite antigen, and a eukaryotic cell which expresses a cytokine, wherein the combination elicits the Th1 immune response in a mammal.