Patent ID: 7544357
Filing Date: 2009-06-09
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of inhibiting differentiation of CD14 + monocytes into dendritic cells capable of antigen presentation, comprising administering an effective amount of (a) at least one interferon antagonist that reduces activity of a type I interferon, wherein the interferon antagonist comprises an anti-IFN-α antibody or an antigen-binding fragment thereof, and (b) at least one Flt3 ligand (Flt3L) antagonist that reduces activity of a Flt3L, wherein the Flt3L antagonist comprises an anti-Flt3L antibody or an antigen-binding fragment thereof, thereby inhibiting CD14 + monocyte differentiation into dendritic cells.