Patent ID: 8999724
Filing Date: 2015-04-07
Classification: G01N

Abstract:
1. A method comprising: exposing a surface of a sensing electrode of a device to an analyte, the surface of the sensing electrode having a probe molecule attached thereto; wherein the device comprises a substrate; at least one drive electrode, the sensing electrode and at least one reference electrode on a surface of the substrate, and an integrating charge amplifier connected to the sensing electrode and configured to detect a change in effective capacitance on the surface of the sensing electrode due to binding of an analyte to the sensing electrode, wherein the sensing electrode comprises a sensing routing path, the reference electrode comprises a reference routing path and the sensing routing path and reference routing path are matched and wherein the reference electrode configured to provide differential measurements of change in charge and effective capacitance; detecting a change in capacitance at an interface of the surface of the sensing electrode and the analyte with the integrating charge amplifier, while changing a parameter that affects molecular interaction between the analyte and the probe molecule; and correlating the change in capacitance with the molecular interaction between the analyte and the probe molecule.