Patent ID: 7667076
Filing Date: 2010-02-23
Classification: C07C,C07D,C07K

Abstract:
1. A method of forming an amide, the method comprising the step of: reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof wherein the amine has the structure of formula (2): wherein R 2 is selected from optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, optionally hetero-, optionally substituted arylalkyl, optionally hetero-, optionally substituted acyl, a carbohydrate moiety, an amino acid moiety, a peptide moiety, a nucleotide moiety, a nucleoside moiety, and a peptide nucleic acid moiety; X is selected from an oxygen atom, a nitrogen atom, and a sulfur atom; and R 3 is selected from hydrogen, optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, optionally hetero-, optionally substituted arylalkyl, optionally hetero-, optionally substituted acyl, and a bond that joins X to R 2 that, taken together with the nitrogen atom, forms a optionally substituted heterocyclic ring of 4 to 7 atoms; whereby an amide bond is formed between the α-carbon of the ketoacid and the nitrogen of the amine.