Patent ID: 6271402
Filing Date: 2001-08-07
Classification: C12P

Abstract:
A compound of the formula I ##STR23##wherein:""a"" is selected from a single bond or a double bond;R.sup.1 is selected from:(a) --OH,(b) --OC(O)CH.sub.3,(c) --OC(O)CH.sub.2 C(CH.sub.3)(OH)CH.sub.2 CO.sub.2 H,(d) --OC(O)CH.sub.2 C(CH.sub.3)(OH)CH.sub.2 CO.sub.2 CH.sub.3,(e) --OC(O)(CH.sub.2).sub.2 CO.sub.2 H,(f) --OC(O)(CH.sub.2).sub.2 CO.sub.2 CH.sub.3,(g) --OC(O)(CH.sub.2).sub.2 CONHOH,(h) --OCH.sub.2 OCH.sub.3,(i) --OC(O)C.sub.6 H.sub.5,(j) --OC(O)CH.sub.2 NH--C(O)OC(CH.sub.3).sub.3,(k) --OSO.sub.2 CH.sub.3,(l) --OC(O)CH.sub.2 NH.sub.2, and(m) --OC(O)--(CH.sub.2).sub.15 --OH;R.sup.2 is selected from:(a) --OH,(b) --OC(O)CH.sub.3,(c) .dbd.O,(d) --OC(O)(CH.sub.2).sub.2 CO.sub.2 H,(e) --OC(O)(CH.sub.2).sub.2 CO.sub.2 CH.sub.3,(f) --OC(O)(CH.sub.2).sub.2 CONHOH,(g) --OCH.sub.2 OCH.sub.3,(h) --OC(O)C.sub.6 H.sub.5,(i) --OC(O)CH.sub.2 NHC(O)OC(CH.sub.3).sub.3,(j) --OSO.sub.2 CH.sub.3,(k) --OSO.sub.2 OH, and(l) --OC(O)CH.sub.2 NH.sub.2 ;or R.sup.1 and R.sup.2 are joined to form: ##STR24##R.sup.3 is selected from:(a) --OH, and(b) --OC(O)CH.sub.3 ;R.sup.4 is selected from:(a) --OH, and(b) --OC(O)CH.sub.3 ;R.sup.5 and R.sup.6 are independently selected from:(a) --H, and(b) --OH,or together form:(c) .dbd.CH.sub.2, or(d) --CH.sub.2 O--;R.sup.7 is selected from:(a) H, and(b) OH;or a pharmaceutically acceptable salt thereof;provided that:whenR.sup.1 is --OH, --OC(O)--(CH.sub.2).sub.15 --OH, --OC(O)(CH.sub.2).sub.2 CO.sub.2 H, or --OC(O)CH.sub.3, andR.sup.2 is --OH, --OSO.sub.2 OH, --OC(O)CH.sub.3, or --OC(O)(CH.sub.2).sub.2 CO.sub.2 H, andR.sup.3 is --OH or --OC(O)CH.sub.3, andR.sup.4 is --OH or --OC(O)CH.sub.3,thenR.sup.5 and R.sup.6 do not together form(a) .dbd.CH.sub.2, or(b) --CH.sub.2 O--.