Patent ID: 8716296
Filing Date: 2014-05-06
Classification: A61P,C07D

Abstract:
1. A compound of general Formula I: or a pharmaceutically acceptable salt or polymorph thereof, including all tautomers and stereoisomers thereof wherein: A is N and B is CH, C(C 1-4 alkyl) or C(NH 2 ), R a is H or methyl; R 1 is selected from the group consisting of: C 1-8 alkyl; —NR 6 R 7 , C 1-6 alkyl-NR 6 R 7 , R 20 , —C 1-6 alkyl-R 20 , —C 1-6 alkyl-C(O)OR 4 , C 1-6 alkyl-C(O)R 4 , —NR 10 —(C 1-6 alkyl)-NR 6 R 7 , —NR 10 —(C 1-6 alkyl)-R 20 , —NR 10 —(C 1-6 alkyl)-C(O)OR 4 , —NR 10 R 20 , O—(C 1-6 alkyl)-NR 6 R 7 , —O—(C 1-6 alkyl)-R 20 , —O—(C 1-6 alkyl)-C(O)OR 4 , —OR 20 , C 1-6 alkyl-OR 20 , C 1-6 alkyl-SR 20 , C 1 -C 6 alklyl-NR 10 R 20 , (C 1-6 alkyl)-O—(C 1-6 alkyl)-R 20 , (C 1-6 alkyl)-S—(C 1-6 alkyl)-R 20 , C(O)R 20 ; where alkyl moieties may be straight or branched and may be substituted by one or more substituents chosen from halo, methoxy, ethoxy NR R R R R C R —O(C OR R each R x represents the number of independently selected R