Patent ID: 8232255
Filing Date: 2012-07-31
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A method for eliciting an immune response against a malaria-causing pathogen in a human, the method comprising: a) priming an immune response in a human by administering a priming composition comprising at least one polynucleotide encoding all or substantially all of the circumsporozoite protein in a priming dose effective to establish the response; and b) boosting the primed immune response in the human by subsequently administering a boosting composition comprising at least one polypeptide which comprises substantially all of the circumsporozoite protein or a fragment thereof in a boosting dose effective to boost the primed immune response wherein administration of the priming composition primes CD8+ T cells and administration of the boosting composition recalls the primed CD8+ T cells, broadens the primed CD8+ T cell response, and results in the generation of anti-malaria CD8+ T cells, anti-malaria CD4+ T cells, and anti-malaria antibodies.