Patent ID: 6083962
Filing Date: 2000-07-04
Classification: A24B,A61K,B82Y,Y10S

Abstract:
A pharmacologic composition for the treatment and reduction of dependency on an abused drug which results in activation of nicotine receptors, said composition comprising:a) a drug acting upon nicotine receptors and which causes activation of those nicotine receptors, said drug being present in the composition in an amount which at least partially satiates the needs for the abused drug by a subject using the composition;b) an antagonist to the drug which is effective to reduce the effects of the drug activating these receptors and present in the composition in an amount sufficient to at least partially block the activation of those receptors by the drug, the antagonist being selected so that these same receptors responsive to the drug are also sensitive to the antagonist, the relative amount of the drug and the antagonist being present in the composition so that there is a substantial systemic amount of the antagonist present when there is a substantial systemic amount of the drug present in the blood of a subject using the composition, the drug or agonist of the drug causing the receptors to be activated and the antagonist causing additional receptors to be blocked, the drug and the antagonist being administered in the proper amounts to preclude intoxication or overdosing and to also reduce pleasure achieved by a subject when the abused drug is administered and to also reduce a state of withdrawal from the abused drug in the subject, such that the drug is complemented by the antagonist to occupy a greater number of receptors of the subject than would be occupied by the drug alone and with the drug and the antagonist having opposing effects on stimulation of the receptors and leaving a lessor number of receptors available to respond to an abused drug.