Patent ID: 7868158
Filing Date: 2011-01-11
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A composition for enhancing the immunopotency of an immune cell, said composition comprising (i) an inhibitor of the expression of any one or more of a suppressor of cytokine signaling (SOCS) selected from the group consisting of: SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and a cytokine-inducible SH2-domain-containing protein (CIS); and (ii) a cytokine or a Toll-like receptor (TLR) agonist, wherein the TLR agonist is selected from the group consisting of: Poly I:C, lipopolysaccharide (LPS), and a CpG oligonucleotide, wherein said inhibitor is a small interfering RNA (siRNA).