Patent ID: 7671207
Filing Date: 2010-03-02
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula 1, said process comprising: (a) condensing a compound of formula 9, with 2,4-thiazolidinedione of formula 12, in a solvent selected from the group consisting of methanol, ethanol, propanol, 2-propanol, butanol, iso-butanol, 2-methoxyethanol, dimethyl formamide, dimethyl sulfoxide, sulfolane, acetonitrile, dioxalane, dimethoxyethane, toluene, acetic acid and their mixtures thereof; in the presence of an organic base selected from the group consisting of ammonia, methyl amine, ethyl amine, n-butyl amine, pyrrolidine, piperidine, pyridine, morpholine, piperazine, diethylamine, di-isopropyl amine and triethyl amine and a catalytic amount of an organic acid selected from the group consisting of acetic acid, p-toluene sulfonic acid, hydrochloric acid and hydrobromic acid to obtain a compound of formula 13; (b) reducing chemoselectively the compound of formula 13 to obtain a compound of formula 14; and (c) reducing the compound of formula 14 to obtain the compound of formula 1; wherein X is selected from the group consisting of OH, Cl, Br, OMs and OTs.