Patent ID: 6287569
Filing Date: 2001-09-11
Classification: A61K,A61P,C12N

Abstract:
A pharmaceutical composition for generating in a patient an MHC-I-mediated cellular immune response to a target antigen(s) comprising a vector comprising a nucleotide sequence encoding a chimeric immunogen, wherein said chimeric immunogen comprisesa) a ubiquitin molecule,b) an intervening amino acid, selected from the group consisting of arginine and tyrosine, positioned at the carboxy terminal end of the ubiquitin molecule, andc) a target antigen, or portion thereof, positioned at the carboxy terminal end of said intervening amino acid, wherein said target antigen is selected from the group consisting of gp100, MART-1, tyrosinase, MAGE-1, MAGE-2, MAGE-3, MAGE-3b, MAGE-4, MAGE-4a, MAGE-4b, MAGE-5a, MAGE-5b, MAGE-6, MAGE-8, MAGE-9, MAGE-10, MAGE-11, MAGE-41, MAGE-Xp, BAGE, N-acetylglucosaminyltransferase-V Intron, p15, MUM-1, MUM-1b, MUM-1c, ErbB-2 (Her-2/neu), CDK4, Human papillomavirus, Human papillomavirus-E6, Human papillomavirus-E7, and Prostate Specific Antigen (PSA).