Patent ID: 6476197
Filing Date: 2002-11-05
Classification: A61K,A61P,C07K,Y02A

Abstract:
An artificial polypeptide derived from a wild-type polypeptide capable of inducing the production of interferon-&ggr; by immunocompetent cells and comprising the amino acid sequence of either SEQ ID NO:4 or SEQ ID NO:5, said artificial polypeptide having the activity of inducing the production of interferon-&ggr; by immunocompetent cells and consisting of a 157-amino acid sequence which comprises (i) the amino acid sequences of SEQ ID NOS: 1 to 3, and (ii) the amino acid sequence of SEQ ID NO:4 or 5 in which one or more cysteine residues are replaced with an amino acid residue(s) other than cysteine.