Patent ID: 7780973
Filing Date: 2010-08-24
Classification: A61L

Abstract:
1. An implantable active agent delivery device for providing an active agent to a subject, the delivery device comprising: (a) a reservoir, wherein the reservoir contains a substance, wherein the reservoir includes openings, wherein the openings are adjacent to the substance; (b) a biomaterial, wherein the biomaterial is near the substance within the reservoir, wherein the openings of the reservoir allow the substance in the reservoir to contact the biomaterial, the biomaterial comprising: (c) an external selectively permeable jacket surrounding the core, the jacket comprising a biocompatible membrane having a molecular weight cutoff permitting passage of molecules of an active agent to and from the core through the jacket to adjacent vascular tissue within the subject; and (d) a tether coupled with the biomaterial, wherein the tether is configured to anchor the biomaterial at an implantation site, wherein the tether comprises a tube configured to replenish the reservoir.