Patent ID: 6677307
Filing Date: 2004-01-13
Classification: A61K,C07K

Abstract:
A PEGylated human TGF&agr; polypeptide of the formula:(R)n-Tâ€²wherein R is a PEG group, n is 1 or 2, Tâ€² is selected from one of the following:a polypeptide of SEQ ID NO:1; a polypeptide extending from amino acid #2 (Val) to amino acid #50 (Ala) of SEQ ID NO:1; a polypeptide extending from amino acid #3 (Ser) to amino acid #50 (Ala) of SEQ ID NO:1; a polypeptide extending from amino acid #4 (His) to amino acid #50 (Ala) of SEQ ID NO:1; a polypeptide extending from amino acid #5 (Phe) to amino acid #50 (Ala) of SEQ ID NO:1; or a polypeptide extending from amino acid #6 (Asn) to amino acid #50 (Ala) of SEQ ID NO:1; and wherein R is attached to Tâ€² at the amino-terminus, at amino acid #29 (Lys) of SEQ ID NO:1 or both.