Patent ID: 7683082
Filing Date: 2010-03-23
Classification: A61K,A61P,C07D

Abstract:
1. A method for testing whether a compound increases activity of a protein encoded by an mRNA that contains a premature stop codon, comprising: (a) contacting a composition comprising a cell extract or cell lysate and the mRNA with an effective amount of a compound of the formula:  or a pharmaceutically acceptable salt thereof, wherein: Z is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heterocycle, substituted or unsubstituted arylalkyl; R R each occurrence of R n is an integer from 1 to 7; and (b) detecting the activity of the protein, wherein a compound that increases the activity of the protein is detected if there is an increase in the activity of the protein in the presence of the compound relative to the absence of the compound.