Patent ID: 8710045
Filing Date: 2014-04-29
Classification: A61P,C07D

Abstract:
1. A compound which is selected from the group consisting of formula I-g, I-h, I-k-1, I-l-1, or I-m-1: wherein (a) the compound of formula I-g or I-h is: wherein W is S or O; n is 0, 1, or 2; q is 0, 1, 2, 3, or 4; each R is located at position 6, 7, 8 or 9 on the benzothiazepine ring; each R is independently selected from the group consisting of halogen, —OH, —NH R R′ and R″ are independently selected from the group consisting of H, halogen, —OH, —NH provided that when q is 0 and n is 0, then —C(═W)NR when q is 0, n is 0 or 2, then —C(═W)NR (b) the compound of formula I-k-1 is: wherein n is 0, 1, or 2; R R p is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; R′ is selected from the group consisting of halogen, —OH, —NH R″ is H; provided that when n is 0, and R′ is OH or C (c) the compound of formula I-l-1 is: wherein n is 0, 1, or 2; R R X is selected from the group consisting of halogen, —CN, —CO R R R′ and R″ are independently selected from the group consisting of H, halogen, —OH, —NH (d) the compound of formula I-m-1 is: wherein n is 0, 1, or 2; R R′ and R″ are independently selected from the group consisting of H, halogen, —OH, —NH