Patent ID: 8853362
Filing Date: 2014-10-07
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A single-chain antibody comprising a variable light chain framework VL and a variable heavy chain framework VH of a human and naturally occurring antibody which is highly stable and soluble under reducing conditions having the general structure: NH NH wherein the single-chain antibody has the VH framework and the VL framework of AJ, BJ, CJ, DJ, EJ, FJ, or GJ; wherein A is the amino acid sequence (Seq. Id. No. 1) B is the amino acid sequence (Seq. Id. No. 2) C is the amino acid sequence (Seq. Id. No. 3) D is the amino acid sequence (Seq. Id. No. 4) E is the amino acid sequence (Seq. Id. No. 5) F is the amino acid sequence (Seq. Id. No. 6) G is the amino acid sequence (Seq. Id. No. 7) H is the amino acid sequence (Seq. Id. No. 8) I is the amino acid sequence (Seq. Id. No. 9) J is the amino acid sequence (Seq. Id. No. 10)