Patent ID: 6028088
Filing Date: 2000-02-22
Classification: C07D

Abstract:
A compound of the formula ##STR17## wherein: Y is S;X is a member selected from the group consisting of O, S and NR.sup.6, wherein R.sup.6 is a member selected from the group consisting hydrogen and optionally substituted (C.sub.1 -C.sub.10)alkyl;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are members independently selected from the group consisting of hydrogen, hydroxy, halogen, optionally substituted (C.sub.1 -C.sub.6)alkyl, optionally substituted (C.sub.1 -C.sub.20)alkoxy, (C.sub.1 -C.sub.6)alkylcarbonyl, (C.sub.1 -C.sub.20)alkenyl, R.sup.24 R.sup.23 N(CH.sub.2).sub.x CH(OH)(CH.sub.2).sub.y O--, optionally substituted aroyl and aryl(C.sub.1 -C.sub.10)alkylcarbonyl;R is a member selected from the group consisting of hydrogen, phenyl, 3,4-dihydroxyphenyl and R.sup.11, whereinR.sup.11 is a member selected from the group consisting of --A--NR.sup.13 R.sup.14, --CONHR.sup.15, --A--S--R.sup.16 and --COOR.sup.17, wherein A denotes a lower alkylene group;R.sup.13 and R.sup.14 are members independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, cycloalkyl and a sulfur- and a nitrogen-containing 5- or 6-membered heterocyclic ring, wherein said heterocyclic ring may be optionally substituted by one or two hydroxyl groups, or, alternatively,R.sup.13 and R.sup.14 together with the nitrogen to which they are bound form a pyrrolidine, piperidine or morpholine ring;R.sup.15 is a member selected from the group consisting of hydrogen and optionally substituted (C.sub.1 -C.sub.6)alkyl;R.sup.16 is a member selected from the group consisting of (C.sub.1 -C.sub.6)alkyl and a sulfur- and nitrogen containing 5- or 6-membered heterocyclic ring wherein said heterocyclic ring may be optionally substituted by one or two hydroxyl groups, carboxyl groups, or (C.sub.1 -C.sub.6)alkoxycarbonyl groups;R.sup.17 is optionally substituted (C.sub.1 -C.sub.6)alkyl;R.sup.23 is a member selected from the group consisting of hydrogen and optionally substituted (C.sub.1 -C.sub.6)alkyl;R.sup.24 is a member selected from the group consisting of phenyl, benzyl, and R.sup.25 (CH.sub.2).sub.s CH(T)(CH.sub.2).sub.k, or a heterocyclic ring having the formula ##STR18## or alternatively, together with R.sup.23 and the nitrogen atom to which they are bound form a 5- or 6-membered heterocyclic ring having the formula ##STR19## R.sup.25 is either phenoxy or unsubstituted, monosubstituted, or disubstituted Ar, wherein,Ar is a member selected from the group consisting of phenyl, pyridinyl, furanyl, thiophenyl, naphthyl, each substituent of monosubstituted Ar is a member selected from the group consisting of hydroxy, (C.sub.1 -C.sub.6)alkoxy, and O(CH.sub.2).sub.r CO.sub.2 R.sup.23, each substituent of disubstituted Ar is independently hydroxy or (C.sub.1 -C.sub.6)alkoxy,Q is a member selected from the group consisting of SO.sub.2, S, or O;x is an integer from 1 to 5;y is an integer from 1 to 5;h is an integer from 1 to 2;k is an integer from 1 to 7;r is an integer from 0 to 2;s is a integer from 0 to 6;T is either hydrogen or OH;Z is a member of the group consisting of CH.sub.2, O, NH, NCH.sub.3, and ##STR20## q is an integer from 0 to 1; n is an integer from 0 to 5;t is an integer from 0 to 1;m is an integer from 0 to 2;p is an integer from 0 to 1;z is an integer from 0 to 1; provided that (1) at least one of x and y is one and (2) s plus k total no more than 7.