Patent ID: 8435792
Filing Date: 2013-05-07
Classification: A61K,A61P,G01N,Y10T

Abstract:
1. A method of identifying a tissue factor pathway inhibitor (TFPI)-inhibiting compound which is capable of enhancing blood coagulation, the method comprising: measuring peak thrombin generation or peak time of a first plasma sample comprising TFPI; contacting a second plasma sample comprising TFPI with a composition comprising a sulfated polysaccharide specifically configured to have a fucose content of 60% or greater; measuring peak thrombin generation or peak time in the second plasma sample; and comparing the peak thrombin generation or peak time of the second plasma sample with the peak thrombin generation or peak time of the first plasma sample, wherein an increase in peak thrombin generation or decrease in peak time of the second plasma sample compared to the first plasma sample indicates that the sulfated polysaccharide is a TFPI-inhibiting compound.