Patent ID: 8829175
Filing Date: 2014-09-09
Classification: A61K,A61P,C07K

Abstract:
1. An episome comprising: (a) a first promoter operationally connected to a first nucleic acid encoding a first polypeptide comprising a polypeptide chain represented by the formula α-factor-a (b) a second promoter operationally connected to a second nucleic acid encoding a polypeptide comprising a second polypeptide chain represented by the formula α-factor-b wherein said first and second polypeptide bind together form a complex comprising at least three antigen binding sites, wherein each of said antigen binding sites comprises a variable domain from said first polypeptide chain and a variable domain from said second polypeptide chain, wherein each of said polypeptides does not bind to itself to form an antigen binding site, wherein said first nucleic acid and said second nucleic acid are coexpressed when the episome is transformed into a host cell.