Patent ID: 6358946
Filing Date: 2002-03-19
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:each R1 is independently selected from the group consisting of hydrogen; C1-8alkyl; halogen; perfluoroC1-4alkyl; hydroxy; C1-4alkoxy; di(C1-4alkyl)amino; amino; amino(C1-8)alkylamino; nitro; C1-4alkoxycarbonyl; and C1-4alkylthio; R2 is selected from the group consisting of hydrogen; C1-6alkyl; aralkyl; heteroarylC1-4alkyl; (R4)2N(CH2)p wherein R4 is the same or different and are independently selected from H, C1-4alkyl, aralkyl, aryl or substituted aryl wherein the substituents are independently selected from C1-4alkyl, C1-4alkoxy, nitro, amino or halo; or R4 together with the nitrogen form a heterocyclic ring selected from piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, piperazinyl, imidazolyl, pyrazolyl, triazolyl, indolyl; indolinyl, benzimidazolyl, pyrrolyl and indazolyl; R5O(CH2)p and R5S(CH2)p wherein R5 is selected from C1-4alkyl, aralkyl, aryl or substituted aryl wherein the substituents are independently selected from C1-4alkyl, C1-4alkoxy, nitro, amino or halo; and p is an integer from 1-5; R3 is selected from the group consisting of aryl; substituted aryl wherein the substituents are independently selected from C1-8alkyl, halo, perfluoroC1-4alkyl, hydroxy, C1-4alkoxy, amino, nitro, di(C1-4alkyl)amino, C1-4alkoxycarbonyl, aminoC2-6alkoxy, C1-8alkylaminoC2-6alkoxy, di (C1-8alkyl) aminoC2-6alkoxy or C1-4alkylthio; a heteroaryl ring selected from pyridyl; thiazolyl; thiophenyl; furyl; indolyl; benzothiophenyl; pyridazinyl; pyrimidinyl; indolyl; imidazolyl; indolinyl; quinolinyl; indazolyl; benzofuryl; triazinyl; pyrazinyl; isoquinolinyl; isoxazolyl; thiadiazolyl; benzothiazolyl; triazolyl; and benzotriazolyl; a substituted heteroaryl ring wherein the substituents are independently selected from oxo, halo, perfluoroC1-4alkyl, amino, nitro, C1-4alkylthio, C1-4alkoxy, C1-4alkylamino, di (C1-4alkyl) amino, carboxy or C1-4alkoxycarbonyl; and cycloalkyl having 3-8 carbon atoms; X is a heterocyclic or carbocyclic ring selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, piperazinyl, imidazolyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, oxazolinyl, triazolyl, tetrazolyl, oxadiazolyl, dioxaazaspirodecanyl, thiadiazolyl, purinyl, benzimidazolyl, benzothiophenyl, benzothiazolyl, indolyl; cyclo(C3-8)alkyl; phenyl; and naphthyl; a substituted heterocyclic, carbocyclic, or aryl ring wherein the substituents are independently selected from C1-8alkyl, halogen, perfluoroC1-4alkyl, hydroxy, amino, nitro, oxo, C1-4-alkoxy, C1-4alkylamino, di(C1-4alkyl)amino, C1-4alkoxycarbonyl, C1-4alkoxyC1-4alkylcarbonyl, aryl, substituted aryl wherein the substituents are independently selected from C1-4alkyl, C1-4alkoxy, nitro, amino or halo; heteroaryl; or C1-4alkylthio; and n is an integer from 1-3; or pharmaceutically acceptable salts thereof.