Patent ID: 6313160
Filing Date: 2001-11-06
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR46##whereinR.sup.1 represents hydrogen, substituted or unsubstituted linear or branched (C.sub.1 -C.sub.6)alkyl, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6)alkenyl, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6)alkynyl, substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl, substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, or OR.sup.4 (wherein R.sup.4 represents hydrogen, substituted or unsubstituted linear or branched (C.sub.1 -C.sub.6)alkyl, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6)alkenyl, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6) alkynyl, aryl, aryl-(C.sub.1 -C.sub.6) alkyl in which the alkyl moiety is linear or branched, substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl, or substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched),R.sup.2 represents hydrogen,X represents oxygen, sulphur, C(H).sub.q (wherein q is equal to 0, 1 or 2), SO, or SO.sub.2,when X is oxygen, sulphur, SO, or SO.sub.2, Y must be C(H).sub.q (wherein q is equal to 0, 1 or 2),Y represents oxygen, sulphur, C(H).sub.q (wherein q is equal to 0, 1 or 2), SO or SO.sub.2,when Y is oxygen, sulphur, SO, or SO.sub.2, X must be C(H).sub.q (wherein q is equal to 0, 1 or 2),it being understood that X and Y cannot simultaneously represent C(H).sub.q (wherein q is equal to 0, 1 or 2),R.sup.3 represents hydrogen, aryl, aryl-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, or linear or branched (C.sub.1 -C.sub.6) alkyl,n is equal to 1, 2, 3, 4 or 5,it being possible for the --(CH.sub.2).sub.n -- chain to be substituted by one or more halogen or one or more identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)alkyl, OH, linear or branched (C.sub.1 -C.sub.6)alkylcarbonyl, and linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl,A represents*NR.sup.5 R.sup.6 whereinR.sup.6 represents hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl,R.sup.5 represents ##STR47##wherein Z represents oxygenor sulphur, and R.sup.7 represents:hydrogen, orR.sup.8 which represents substituted or unsubstituted linear or branched (C.sub.1 -C.sub.6)alkyl, substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl, substituted or unsubstituted (C.sub.3 -C.sub.8)cycloalkyl-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6)alkenyl, substituted or unsubstituted linear or branched (C.sub.2 -C.sub.6)alkynyl, aryl, or aryl-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched,or NR.sup.8 R.sup.9 wherein R.sup.9 represents hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl and R.sup.8 is as defined hereinabove,the symbol ##STR48##means that the bonds can be single or double, it being understood that two adjacent bonds cannot simultaneously be double and that the valency of the atoms is respected,it being understood that:the term ""aryl"" denotes phenyl or naphthyl optionally substituted by one or more halogen or one or more identical or different groups selected from OH, linear or branched (C.sub.1 -C.sub.6)alkoxy, linear or branched (C.sub.1 -C.sub.6)alkyl, cyano, nitro, amino, alkylamino, dialkylamino, and tahaloalkyl,the term ""substituted"" used in respect of the terms ""alkyl"", ""alkenyl"" and ""allynyl"" means that the group is substituted by one or more halogen or one or more identical or different groups selected from OH, linear or branched (C.sub.1 -C.sub.6)alkoxy, amino, alkylamino and dialkylamino,the term ""substituted"" used in respect of the terms ""cycloalkyl"" and ""cycloalkylalkyl"" means that the cyclic moiety is substituted by one or more halogen or one or more identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxy, oxo, amino, alkylamino, and dialkylamino,provided that:when the compound of formula (I) is a chroman compound (X represents CH.sub.2, Y represents oxygen and R.sup.1, R.sup.2 and R.sup.3 are as defined hereinabove and the bonds {character pullout} are single), the group --(CH.sub.2).sub.n --A is other than the following groups:--CH.sub.2 --NHCOR.sub.e (wherein R.sub.e repesents cycloalkyl) in the 2-position of the chroman group,when A represents NHCSNHR.sup.8 and n is equal to 2, R.sup.8 cannot represent aryl,when X represents CH.sub.2, A cannot represent urea or thiourea substituted by substituted or unsubstituted phenyl,its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.