Patent ID: 6780865
Filing Date: 2004-08-24
Classification: C07D

Abstract:
A compound having the following structure: or a structure according to formula I: wherein R1 has the formula II: R2 and R3 are independently C(1-12) alkyl, optionally, R2 having one or two nonadjacent carbon atoms of the C(1-12) alkyl being replaced by an oxygen atom; and wherein:C* is a chiral carbon atom; n is four; R4 is a naturally occurring amino acid attached by an oxygen atom to the chiral carbon atom C* by an ester linkage, â€”Oâ€”Xâ€”(R5)m; m being two or three, depending on valence, and X being selected from the group consisting of C, P or S; wherein one R5 is &boxH;O and any other R5 is a member independently selected from Group Q, and Group Q consists of:hydroxyl group; substituted or unsubstituted C(3-10) allyl, C(2-10) alkenyl, C(1-10) alkynyl, C(1-10) alkoxyl, C(1-10) oxoalkyl, C(1-10) carboxyalkyl, C(1-10) hydroxyalkyl, or substituted C(1-2) alkyl group; â€”OR6, R6 being a substituted or unsubstituted C(1-10) alkyl, C(2-10) alkenyl, C(2-10) alkynyl, or C(1-10) oxoalkyl; substituted or unsubstituted heterocylic group, attached to X through an atom within the ring, having one or two rings, each ring containing from four to seven atoms, wherein the heteroatom(s) of said heterocyclic group is 1 or 2 nitrogens; and substituted or unsubstituted carbocyclic group that is attached to X through a carbon atom within a ring, having one or two rings, each ring containing four to seven atoms, wherein the substituents of said substituted carbocyclic group are selected from the group consisting of amino, C(2-6) alkenyl, C(1-6) alkyl, C(1-6) alkoxyl, C(1-6) hydroxyalkyl, hydroxyl, C(1-6) oxoalkyl, azido, cyano, C(2-6) mono- or di-haloalkyl, isocyano, isothiocyano, imino, a chlorine atom, a bromine atom, a fluorine atom and an oxygen atom.