Patent ID: 7262183
Filing Date: 2007-08-28
Classification: A61K,A61P,C07D

Abstract:
1. A compound is selected from the group consisting of: 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 3-phenoxy-1-propyl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 2-[N-ethyl-N-(3-methylphenyl)]amino-1-ethyl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 2-(2-thienyl)-1-ethyl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, dec-9-en-1-yl (2S)-5,5-dimethyl-1-(2-cyclohexyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(2-cyclopentyl-1,2-dioxoethyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, 3-phenoxy-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, 2-[N-ethyl-N-(3-methylphenyl)]amino-1-ethyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, 2-(2-thienyl)-1-ethyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 3-(6-methyl-2-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 1-phenoxy-2-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 3-cyclohexyl-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, (1R)-1-(4-methoxyphenyl)-3-phenyl -1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 3-(N,N-dibenzylamino)-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, dec-9-en-1-yl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, (2R)-1-methoxy-2-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2-dioxobutyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxooctyl)-2-(4-thiazolidine)carboxylate, 3-(6-methyl-2-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxooctyl)-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxooctyl)-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-(1,2-dioxooctyl)-2-(4-thiazolidine)carboxylate, 2-(2-chlorophenyl)-1-ethyl (2S)-5,5-dimethyl-1-(1,2-dioxooctyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxodecyl)-2-(4-thiazolidine)carboxylate, 3-(6-methyl-2-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxodecyl)-2-(4-thiazolidine)carboxylate, 2-(2-chlorophenyl)-1-ethyl (2S)-5,5-dimethyl-1-(1,2-dioxodecyl)-2-(4-thiazolidine)carboxylate, (2R)-1-methoxy-2-propyl (2S)-5,5-dimethyl-1-(1,2-dioxodecyl)-2-(4-thiazolidine)carboxylate, 2-pentyl (2S)-5,5-dimethyl-1-(1,2-dioxodecyl)-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxo-2-phenyl)ethyl-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxo-2-phenyl)ethyl-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-(1,2-dioxo-2-phenyl)ethyl-2-(4-thiazolidine)carboxylate, 3-cyclohexyl-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxo-2-phenyl)ethyl-2-(4-thiazolidine)carboxylate, dec-9-en-1-yl (2S)-5,5-dimethyl-1-(1,2-dioxo-2-phenyl)ethyl-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-[2-(4-chlorophenyl)-1,2-dioxoethyl]-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl]ethyl-2-(4-thiazolidine)carboxylate, 3-phenyl-1-propyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, (E)-3-phenyl-prop-2-en-1-yl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 3-cyclohexyl-1-propyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 3-phenoxy-1-propyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 2-(2-thienyl)-1-ethyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 2-aminobenzyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 2-(N-benzyl-N-methyl)amino-1-ethyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 1-phenoxy-2-propyl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, dec-9-en-1-yl (2S)-5,5-dimethyl-1-[1,2-dioxo-2-(2,4,6-trimethylphenyl)]ethyl-2-(4-thiazolidine)carboxylate, 3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(1,2-dioxo-4-methyl-4-phenyl)pentyl-2-(4-thiazolidine)carboxylate, and 2-phenylbenzyl (2S)-5,5-dimethyl-1-(1,2-dioxo-4-methyl-4-phenyl)pentyl-2-(4-thiazolidine)carboxylate, or a pharmaceutically acceptable salt or a hydrate thereof.