Patent ID: 8173167
Filing Date: 2012-05-08
Classification: A61K

Abstract:
1. A micelle composition comprising a plurality of micelles, wherein the micelles comprise an amphiphilic linear polymer, a hydrophobic excipient, and a hydrophobic passenger drug, wherein the hydrophobic excipient and the hydrophobic passenger drug are located within the micelles; wherein the mol % ratio of hydrophobic excipient to amphiphilic polymer is at least 10:1 and the concentration of the amphiphilic polymer is about 0.05 mM to about 1.7 mM; the micelles have a critical micelle concentration (CMC) of about 0.26 μM to about 28 μM; the amphiphilic linear polymer is PEG-poly(ε-caprolactone) (PEG-PCL); the hydrophobic excipient is Vitamin E; and the hydrophobic passenger drug is selected from the group consisting of rapamycin, paclitaxel, paclitaxel prodrugs comprising a carbonyloxy- or silyloxy-linked prodrug moiety at one or both of the paclitaxel positions C2 and C7, geldanamycin, and geldanamycin prodrugs comprising a nitrogen-linked prodrug moiety at the geldanamycin C17 in place of the C17 methoxy group; wherein when present, the presence of the paclitaxel prodrug moiety or geldanamycin prodrug moiety increases the octanol-water partition coefficient log Po/w of the paclitaxel or geldanamycin prodrug compared to paclitaxel or geldanamycin, respectively.