Patent ID: 8648102
Filing Date: 2014-02-11
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of treating a disease selected from the group consisting of rheumatoid arthritis, inflammatory bowel disease, osteoarthritis, leiomyomas, adenomas, lipomas, hemangiomas, fibromas, vascular occlusion, restenosis, pre-neoplastic lesions, carcinoma in situ, oral leukoplakia, melanoma, non-small cell lung cancer, small cell lung cancer, lung cancer, hepatocarcinoma, retinoblastoma, astrocytoma, glioblastoma, neuroblastoma, mesothelioma, lymphoma, head cancer, neck cancer, breast cancer, pancreatic cancer, renal cancer, bone cancer, testicular cancer, ovarian cancer, cervical cancer, gastrointestinal cancer, colon cancer, bladder cancer, blood cancer, brain cancer, skin cancer, eye cancer, tongue cancer, and gum cancer, comprising the administration, to a patient in need thereof, of a therapeutically acceptable amount of a compound comprising the chemical formula: wherein R where X R R where Z is NH; and where X R