Patent ID: 6124295
Filing Date: 2000-09-26
Classification: C07D

Abstract:
A compound of the formula: ##STR122## or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c and d represents N or NR.sup.9 wherein R.sup.9 is O.sup.--, --CH.sub.3 or --(CH.sub.2).sub.n CO.sub.2 H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR.sup.1 or CR.sup.2 ; oreach of a, b, c, and d are independently selected from CR.sup.1 or CR.sup.2 ;each R.sup.1 and each R.sup.2 is independently selected from H, halo, --CF.sub.3, --OR.sup.10, --COR.sup.10, --SR.sup.10, --S(O).sub.t R.sup.11 (wherein t is 0, 1 or 2), --SCN, --N(R.sup.10).sub.2, --NR.sup.10 R.sup.11, --NO.sub.2, --OC(O)R.sup.10, --CO.sub.2 R.sup.10, --OCO.sub.2 R.sup.11, --CN, --NHC(O)R.sup.10 ; --NHSO.sub.2 R.sup.10, --CONHR.sup.10, --CONHCH.sub.2 CH.sub.2 OH, --NR.sup.10 COOR.sup.11, ##STR123## --SR.sup.11 C(O)OR.sup.11, --SR.sup.11 N(R.sup.75).sub.2 wherein each R.sup.75 is independently selected from H and --C(O)OR.sup.11, benzotriazol-1-yloxy, tetrazol-5-ylthio, or substituted tetrazol-5-ylthio, alkynyl, alkenyl or alkyl, said alkyl or alkenyl group optionally being substituted with halo, --OR.sup.10 or --CO.sub.2 R.sup.10 ;R.sup.3 and R.sup.4 are the same or different and each independently represents H, any of the substituents of R.sup.1 and R.sup.2, or R.sup.3 and R.sup.4 taken together represent a saturated or unsaturated C.sub.5 -C.sub.7 fused ring to the benzene ring (Ring III);R.sup.5, R.sup.6, R.sup.7 and R.sup.8 each independently represents H, --CF.sub.3, --COR.sup.10, alkyl or aryl, said alkyl or aryl optionally being substituted with --OR.sup.10, --SR.sup.10, --S(O).sub.t R.sup.11, --NR.sup.10 COOR.sup.11, --N(R.sup.10).sub.2, --NO.sub.2, --COR.sup.10, --OCOR.sup.10, --OCO.sub.2 R.sup.11, --CO.sub.2 R.sup.10, OPO.sub.3 R.sup.10 or R.sup.5 is combined with R.sup.6 to represent .dbd.O or .dbd.S and/or R.sup.7 is combined with R.sup.8 to represent .dbd.O or .dbd.S;R.sup.10 represents H, alkyl, aryl, or aralkyl;R.sup.11 represents alkyl or aryl;the dotted line between carbon atoms 5 and 6 represents an optional double bond, such that when a double bond is present, A and B independently represent --R.sup.10, halo, --OR.sup.11, --OCO.sub.2 R.sup.11 or --OC(O)R.sup.10, and when no double bond is present between carbon atoms 5 and 6, A and B each independently represent H.sub.2, --(OR.sup.11).sub.2 ;H and halo, dihalo, alkyl and H, (alkyl).sub.2, --H and --OC(O)R.sup.10, H and --OR.sup.10, .dbd.O, aryl and H, .dbd.NOR.sup.10 or --O--(CH.sub.2).sub.p --O-- wherein p is 2, 3 or 4; andW represents a group selected from: --SO.sub.2 R.sup.12 or --P(O)R.sup.13 R.sup.14 ;R.sup.12 is selected from the group consisting of:(1) alkyl;(2) aralkyl;(3) cycloalkyl;(4) aryl;(5) heteroaryl;(6) substituted heteroaryl wherein said heteroaryl is as defined above and said substituents are selected from: (a) heteroaryl, (b) alkyl, (c) aryl, (d) aralkyl, (e) --OR.sup.10, and (f) N(R.sup.10).sub.2 ;(7) camphor; and(8) --NR.sup.15 R.sup.16 wherein R.sup.15 and R.sup.16 are independently selected from the group consisting of: (a) H, (b) alkyl, (c) aryl, (d) aralkyl, (e) heteroaryl, and (f) heterocycloalkyl; andR.sup.13 and R.sup.14 are independently selected from the group consisting of:(1) H;(2) alkyl;(3) aryl;(4) aralkyl; and(5) --OR.sup.13 wherein R.sup.13 is as defined above.