Patent ID: 7776846
Filing Date: 2010-08-17
Classification: A61K,A61P,Y10S

Abstract:
1. A method for enhancing the anti-inflammatory activity or duration of action, or both, of a compound having the formula: wherein: R Z is carbonyl or β-hydroxymethylene; X is Cl or F; R Y is —OH, —SH or —OCOR and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated; following topical or other local administration of said compound to a warm-blooded animal in need of treatment to alleviate a topical or other localized inflammatory response, said method comprising topically or otherwise locally co-administering said compound to said animal with a synergistically effective amount of a compound having the formula: wherein: R is H or C Z X R and the dotted line is defined as above; with the proviso that when R is C the amount of compound of formula (II) being sufficient to enhance the anti-inflammatory activity or duration of action, or both, of said compound having formula (Ia) or (Ib).