Patent ID: 6248354
Filing Date: 2001-06-19
Classification: A61K,A61P

Abstract:
A capsule system for oral delivery of an active agent having low aqueous solubility, said capsule system comprising:an active retinoid agent having low aqueous solubility consisting of Tazarotene;vehicle means for initially dissolving the active agent;emulsifier means for promoting self-emulsification of the active agent and vehicle means in the gastrointestinal tract; andcapsule shell means for encapsulating the active agent, vehicle means, and emulsifier means as a non-emulsified, homogeneous mixture, said capsule shell means being formulated to open upon ingestion into said gastrointestinal tract and release the mixture, thus enabling self-emulsification of the vehicle means, with the active agent dissolved therein in the gastrointestinal tract.