Patent ID: 9085805
Filing Date: 2015-07-21
Classification: C12Q

Abstract:
1. In vitro method for diagnosing and/or monitoring in a subject a gastrointestinal stromal tumor, the method comprising: detecting in a test sample derived from the subject one or more tumor specific mutations at the DNA level in any one or both of the marker genes cKIT (GenBank acc. no. NM determining the amount of tumor specific mutated DNA, wherein the amount of tumor specific mutated DNA is determined by directly comparing tumor specific mutated and wild-type DNA fractions; wherein the DNA is circulating DNA; wherein the presence of any one of the tumor specific mutations detected in the test sample is indicative of a gastrointestinal stromal tumor in the subject; and wherein an elevated amount of tumor specific mutated DNA is indicative of gastrointestinal stromal tumor progression.