Patent ID: 7148234
Filing Date: 2006-12-12
Classification: A61K,A61P

Abstract:
1. A method of treating atherosclerosis comprising administering to a mammal, in need thereof, an effective amount of an EP4 receptor antagonist; wherein said EP4 receptor antagonist is a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein one of Y R Q A is a 5–6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, wherein said 5–6 membered monocyclic aromatic ring is optionally substituted with up to 3 substituents selected from halo, C B is halo-substituted C W is NH, N—C R Z is a 5–12 membered monocyclic or bicyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, wherein said 5–12 membered monocyclic or bicyclic aromatic ring is optionally substituted with halo, C L is halo, C m is 0, 1 or 2; R R Q