Patent ID: 6908922
Filing Date: 2005-06-21
Classification: A61P,C07D

Abstract:
1. A compound selected from those of formula (I): wherein: V represents a single bond or a linear or branched (C M represents a single bond or a linear or branched (C A and E each represents nitrogen or CH, but at least one of the two groups A or E represents nitrogen, W represents a group of formula (i): X represents carbonyl, G R Y represents aryloxy, heteroaryloxy or heteroaryl-B, each of which groups may optionally be substituted by one or more groups, which may be the same or different, selected from hydrogen, halogen, linear or branched (C its isomers, its hydrates, its solvates and addition salts thereof with a pharmaceutically acceptable acid, wherein: aryl is understood to mean a group selected from phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl, indenyl and benzocyclobutyl, heteroaryl-A is understood to mean a monocyclic aromatic or bicyclic, 5- to 12-membered system containing one or two hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur, and wherein, in the case of a bicyclic system, one of the rings has an aromatic character and the other ring may be aromatic or partially hydrogenated, heteroaryl-B is understood to mean a monocyclic aromatic or bicyclic aromatic, 5- to 12-membered system containing from 1 to 3 hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur, aryloxy is understood to mean aryl as defined hereinbefore attached to oxygen, heteroaryloxy is understood to mean heteroaryl-A as defined hereinbefore attached to an oxygen atom, with the proviso that: when V represents a single bond and W represents a group of formula (i) wherein R when M represents a single bond and W represents a group of formula (i), then if Y represents a bicyclic heteroaryl-B group wherein one of the rings represents a benzene ring the said group Y cannot be joined to M by the said benzene ring, and when M represents a single bond, V represents ethylene and W represents a group of formula (i) wherein R