Patent ID: 8562948
Filing Date: 2013-10-22
Classification: A61K,A61P,C07K

Abstract:
1. A method of visualizing malignant cells having somatostatin receptor-2 (SST2) and/or somatostatin receptor-5 (SST5) that bind a somatostatin analog in a subject comprising administering to the subject a compound selected from any one of 4-amino-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH 2 (SEQ ID NO:1); 4-amino-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH 2 (SEQ ID NO:2); 4-amino-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-D-Asp-NH 2 (SEQ ID NO:3); 4-amino-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-D-Thr-NH 2 (SEQ ID NO:4); 4-amino-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH 2 (SEQ ID NO:5); 4-amino-3-iodo-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH 2 (SEQ ID NO:6); 4-amino-3-iodo-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH 2 (SEQ ID NO:7); 4-amino-3-iodo-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH 2 (SEQ ID NO:8); 4-amino-3-iodo-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH 2 (SEQ ID NO:9); and D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH 2 (SEQ ID NO:10), wherein the compound is labeled with a detectable label, and visualizing malignant cells that bind the compound.