Patent ID: 6417359
Filing Date: 2002-07-09
Classification: A61K

Abstract:
A compound having the formula: wherein Xâ€² is nitrogen and X is nitrogen or carbon bonded to a substituent selected from the group consisting of H, F, Cl, Br, I, Râ€², NRâ€²Râ€³, CF3, OH, CN, NO2, C2Râ€², SH, SCH3, N3, SO2CH3, ORâ€², SRâ€², C(&boxH;O)NRâ€²Râ€³, NRâ€²C(&boxH;O)Râ€², C(&boxH;O)Râ€², C(&boxH;O)ORâ€², (CH2)qORâ€², OC(&boxH;O)Râ€², OC(&boxH;O)NRâ€²Râ€³, and NRâ€²C(&boxH;O) ORâ€², where Râ€² and Râ€³ are individually hydrogen, C1-C10 alkyl, an aromatic group-containing species, and q is an integer from 1 to 6; A, Aâ€² and Aâ€³ are the same substituents as the X substituents; Zâ€² and Zâ€³ are substituents selected from the group consisting of alkyl, aryl, aralkyl, halo, hydroxyl, alkoxyl, alkylhydroxy, cyano, and mercapto; wherein Zâ€³ additionally can be hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Y is C&boxH;O, C(OH)Râ€² or CHA, where Râ€² is hydrogen or lower alkyl.