Patent ID: 6416793
Filing Date: 2002-07-09
Classification: A61K

Abstract:
A process for the preparation of a composition comprising the steps of:a. heating one or more solubilizing emulsifiers selected from the group consisting of vitamin E succinate polyethylene glycol 1000, polyvinylpyrrolidone, polyoxyethylene stearate, sodium cholate, deoxycholate and taurocholate; b. adding to the product of step (a) a solvent and a surfactant phospholipid selected from the group consisting of phosphatidyl choline, dioleoyl phosphatidyl choline, phosphatidylglycerol, dioleoylphosphatidylglycerol, dimyristoylphosphatidylcholine, dipalitoylphosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and sphingomyelin to produce a solution; c. dissolving in the solution of step (b) one or more phytochemicals or compositions comprising phytochemicals selected from the group consisting of Pausinystalia yohinbe bark extracts, Tabernanthe iboga extracts, yohimbine, ibogaine, corynanthine, and rauwolscine; d. adding to the solution of step (c) a solution containing an encapsulator; e. mixing the solution produced in step (d) to produce a microdispersion with a particle size of 5 microns or less; and f. spray drying the resulting mixture to leave a solid hydrophobic phytochemical composition.