Patent ID: 6271253
Filing Date: 2001-08-07
Classification: A61P,C07D

Abstract:
A compound of Formula I"" ##STR237##wherein X is selected from S, CR.sup.c R.sup.b and NR.sup.a ;wherein R.sup.a is selected from hydrido, C.sub.1 -C.sub.3 -alkyl, (optionally substituted phenyl)-C.sub.1 -C.sub.3 -alkyl, acyl and carboxy-C.sub.1 -C.sub.6 -alkyl;wherein each of R.sup.b and R.sup.c is independently selected from hydrido, C.sub.1 -C.sub.3 -alkyl , phenyl-C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -perfluoroalkyl, chloro, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkoxy, nitro, cyano and cyano-C.sub.1 -C.sub.3 -alkyl; or wherein CR.sup.b R.sup.c forms a 3-6 membered cycloalkyl ring;wherein R is selected from carboxyl, aminocarbonyl, C.sub.1 -C.sub.6 -alkylsulfonylaminocarbonyl and C.sub.1 -C.sub.6 -alkoxycarbonyl;wherein R"" is selected from hydrido, phenyl, thienyl, C.sub.1 -C.sub.6 -alkyl and C.sub.2 -C.sub.6 -alkenyl;wherein R.sup.1 is selected from C.sub.1 -C.sub.3 -perfluoroalkyl, chloro, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkoxy, nitro, cyano and cyano-C.sub.1 -C.sub.3 -alkyl;wherein R.sup.2 is one or more radicals independently selected from hydrido, halo, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, halo-C.sub.2 -C.sub.6 -alkynyl, aryl-C.sub.1 -C.sub.3 -alkyl, aryl-C.sub.2 -C.sub.6 -alkynyl, aryl-C.sub.1 -C.sub.6 -alkenyl, C.sub.1 -C.sub.6 -alkoxy, methylenedioxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl, aryloxy, arylthio, arylsulfinyl, heteroaryloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, aryl-C.sub.1 -C.sub.6 -alkyloxy, heteroaryl-C.sub.1 -C.sub.6 -alkyloxy, aryl-C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -haloalkoxy, C.sub.1 -C.sub.6 -haloalkylthio, C.sub.1 -C.sub.6 -haloalkylsulfinyl, Cl-C.-haloalkylsulfonyl, C.sub.1 -C.sub.3 -(haloalkyl-C.sub.1 -C.sub.3 -hydroxyalkyl, C.sub.1 -C.sub.6 -hydroxyalkyl, hydroxyimino-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkylamino, arylamino, aryl-C.sub.1 -C.sub.6 -alkylamino, heteroarylamino, heteroaryl-C.sub.1 -C.sub.6 -alkylamino, nitro, cyano, amino, aminosulfonyl, C.sub.1 -C.sub.6 -alkylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, aryl-C.sub.1 -C.sub.6 -alkylaminosulfonyl, heteroaryl-C.sub.1 -C.sub.6 -alkylaminosulfonyl, heterocyclylsulfonyl, C.sub.1 -C.sub.6 -alkylsulfonyl, aryl-C.sub.1 -C.sub.6 -alkylsulfonyl, optionally substituted aryl, optionally substituted heteroaryl, aryl-C.sub.1 -C.sub.6 -alkylcarbonyl, heteroaryl-C.sub.1 -C.sub.6 -alkylcarbonyl, heteroarylcarbonyl, arylcarbonyl, aminocarbonyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, formyl, C.sub.1 -C.sub.6 -haloalkylcarbonyl and C.sub.1 -C.sub.6 -alkylcarbonyl; andwherein the A ring atoms A.sup.1, A.sup.2, A.sup.3 and A.sup.4 are independently selected from carbon and nitrogen with the proviso that at least two of A.sup.1, A.sup.2, A.sup.3 and A.sup.4 are carbon;or wherein R.sup.2 together with ring A forms a radical selected from naphthyl, quinolyl, isoquinolyl, quinolizinyl, quinoxalinyl and dibenzofuryl;or an isomer or pharmaceutically acceptable salt thereof.