Patent ID: 8492526
Filing Date: 2013-07-23
Classification: A61K,A61P,C07K

Abstract:
1. A recombinant antibody composition comprising a human IgG1 antibody, wherein said antibody comprises a CH2 domain in which the amino acids at positions 276 and 339, as indicated by the EU index as in Kabat, et al., are substituted with different amino acids; wherein the substitution at position 276 is with an amino acid selected from the group consisting of aspartic acid, leucine, serine and lysine; wherein the substitution at position 339 is with an amino acid selected from the group consisting of aspartic acid, phenylalanine, isoleucine, lysine, asparagine, serine, tryptophan, tyrosine and threonine; and wherein said antibody exhibits improved complement-dependent cytotoxic activity over the IgG1 antibody prior to said substitutions.