Patent ID: 6395755
Filing Date: 2002-05-28
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl) or OCON(C1-C6 alkyl)2; R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl or 4-hydroxycyclohexyl; R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen atom to which they are attached, piperidinyl, morpholino, pyrrolidinyl, 3-methylpyrrolidinyl, 3,3-dimethylpyrrolidinyl, 3,4-dimethylpyrrolidinyl, azepinyl, or pipecolinyl; R6 is >C&boxH;CH2, >CH(C2-C5 alkenyl), >CH&boxH;CH(C1-C5 alkyl), >CH(aryl), >C(OH)(C1-C5 alkyl), >C(OH)(C2-C5 alkenyl), >C(OH)(aryl); or a pharmaceutically acceptable salt thereof.