Patent ID: 7553831
Filing Date: 2009-06-30
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula I where R —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, —NR 1-a R 1-b where R 1-a and R 1-b are —H or C 1 -C 6 alkyl, and —OC═O NR 1-a R 1-b where R 1-a and R 1-b are as defined above, where the R 1-heteroaryl group is bonded to —(CH 2 ) n1 — by any ring atom of the parent R N-heteroaryl group substituted by hydrogen such that the new bond to the R 1-heteroaryl group replaces the hydrogen atom and its bond, where heteroaryl is optionally substituted with one, two, three, or four: (1) C (2) C (3) C (4) —F, Cl, —BR, or —I, (6) —C (7) —NR (8) —OH, (9) —C≡N, (10) C (11) —CO—(C (12) —SO (13) —CO—NR (14) —SO (VIII) —(CH where the R 1-heterocycle group is bonded by any atom of the parent R 1-heterocycle group substituted by hydrogen such that the new bond to the R 1-heterocycle group replaces the hydrogen atom and its bond, where heterocycle is optionally substituted with one, two, three, or four: (1) C (2) C (3) C (4) —F, Cl, —Br, or —I, (5) C (6) —C (7) —NR (8) —OH, (9) —C≡N, (10) C (11) —CO—(C (12) —SO (13) —CO—NR (14) —SO (15) ═O, with the proviso that when n where R where R where R 2 and R 3 are taken together with the carbon to which they are attached to form a carbocycle of three, four, five, six or seven carbon atoms, optionally where one carbon atom is replaced by a heteroatom selected from the group consisting of —O—, —S—, —SO 2 —, and —NR N-2 —, where R where one X is —C(O)—and the other is —CH2—, wherein in the rings drawn, a dotted line indicates an optional double bond or an optional ring; wherein ring A is phenyl; and where R where n is equal to 0, 1, 2 or 3; where Z is selected from the group consisting of: where R where R where R where the ring or fused rings may optionally have one, two, or three substituents independently chosen from the group of: or a pharmaceutically acceptable salt thereof.