Patent ID: 6759420
Filing Date: 2004-07-06
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound of formula (I): in any stereoisomeric form, or a physiologically acceptable salt thereof, wherein:R(1) is C6 aryl, wherein aryl is unsubstituted or substituted by 1, 2, or 3 identical or different groups R(8); R(2) is hydrogen or (C1-C4)-alkyl; R(3) is (C6-)-aryl-(C1-C4)-alkyl which is substituted in the aryl or alkyl moiety by a group R(11); R(4) is hydrogen, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkyl, or (C6-C10)-aryl (C1-C4)-alkyl; R(5) is (C3-C7)-cycloalkyl, wherein cycloalkyl is unsubstituted or substituted with hydroxy, benzyloxy, hydroxycarbonyl, or N(R(9))2; R(6a) and R(6b) independently of each other are hydrogen or (C1-C8)-alkyl which is unsubstituted or substituted by 1, 2, or 3 identical or different groups R(15); R(8) is (C1-C10)-alkyl, (C1-C6)-alkoxy, (C3-C10)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkyl, SO2-(C1-C4)-alkyl, fluoro, chloro, bromo; or (C1-C10)-alkyl, (C1-C6)-alkoxy, (C3-C10)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkyl or SO2-(C1-C4)-alkyl in which one or more of the hydrogen atoms in the alkyl part or cycloalkyl part of the foregoing have been replaced by fluoro, chloro, or bromo; or two groups R(8) form a â€”Oâ€”(CH2)2)Oâ€” bridge or aâ€”(CH2)4-bridge; R(9) is R(10) or (C6-C10)-aryl-(C1-C4)-alkyl; R(10) is hydrogen, nitro, (C1-C6)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxycarbonyl, (C1-C18)-alkylcarbonyloxy-(C1-C6)-alkoxycarbonyl, (C6-C14)-arylcarbonyl which is optionally substituted, (C6-C14)-aryloxycarbonyl which is optionally substituted, or (C6-C14)-aryl-(C1-C6)-alkoxycarbonyl which is optionally substituted in the aryl moiety; R(11) is R(12) or (C1-C4)-alkyl which is unsubstituted or substituted by a group R(12); R(12) is N(R(9))2, CON(R(9))2, CN, chloro, NR(10)â€”C(&boxH;NR(13)â€”NHR(10), C(&boxH;NR(13))NHR(10), or S(O)(&boxH;NR(9))â€”N(R(9))2; R(13) is R(10), cyano, nitro, amino, hydroxy, (C1-C6)-alkoxy, or (C6-C14)-aryl-(C1-C6)-alkoxy which is unsubstituted or substituted in the aryl moiety by (C1-C4)-alkoxy, chloro, or (C1-C4)-alkyl; R(15) is a six membered saturated or unsaturated heterocyclic ring with one nitrogen atom and five carbon atoms, which is unsubstituted or substituted with a group R(23); R(23) is hydrogen, â€”C(&boxH;NR(9))â€”R(39), R(9), oxo, R(11), â€”NHâ€”S(O)(&boxH;NR(9))-(C1-C4)-alkyl, or â€”S(O)(&boxH;NR(9))â€”N(R(9))2; and R(39) is hydrogen, (C8-C10)-aryl, or (C1-C6)-alkyl, which are unsubstituted or substituted by cyano.