Patent ID: 9211287
Filing Date: 2015-12-15
Classification: A61K,C07D

Abstract:
1. A method of: (a) treating a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder or a neuronal disorder; (b) lowering blood pressure; (c) (i) increasing renal blood flow, and/or (ii) decreasing or inhibiting sodium reabsorption; (d) treating a disease or condition that is hypertension, hypertensive emergency or a cardiac or renal disease or condition; (e) regulating blood glucose levels; (f) (i) increasing insulin secretion, and/or (ii) promoting insulin release into the blood stream; (g) treating a disease or condition that is type 2 diabetes, glucose intolerance or metabolic syndrome; or (h) delaying the onset of a disease or condition that is type 2 diabetes, glucose intolerance or metabolic syndrome; in an individual in need thereof comprising administering to the individual an effective amount of a compound of the formula (IA), (J-1), (J-2), (J-3), (J-4), (J-5), (K-1), (K-2), (K-3), (K-4) or (K-5): wherein the formula (IA) is: or a salt or solvate thereof; wherein: R each R each R each R each X each m, n, o and p is independently 0 or 1; each R each R Q is a group of the formula —CR the formula (J-1), (J-2), (J-3), (J-4), or (J-5) is: or a salt or solvate thereof, wherein: R each R each X each R each R Q is a group of the formula —CR wherein R 9 is H or a substituted or unsubstituted C 1 -C 8 alkyl and R 10a and R 10b are taken together with the carbon to which they are attached to form a substituted or unsubstituted cycloalkyl, cycloalkenyl or heterocyclyl moiety; the formula (K-1), (K-2), (K-3), (K-4), or (K-5) is: or a salt or solvate thereof, wherein: R each R each X each R each R Q is a group of the formula —CR wherein R 9 is H or a substituted or unsubstituted C 1 -C 8 alkyl and R 10a and R 10b are taken together with the carbon to which they are attached to form a substituted or unsubstituted cycloalkyl, cycloalkenyl or heterocyclyl moiety.