Patent ID: 6251869
Filing Date: 2001-06-26
Classification: A61K,A61P,Y02A

Abstract:
A method for treating gram-negative organisms infections in mammal which comprises administration of an effective amount of an oxazolidinone antibacterial agent and an arginine derivative of formula A ##STR4##wherein R.sub.1 isa) aryl, optionally substituted with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkythio, halo, or --NH.sub.2,b) --(CH.sub.2).sub.i --aryl, in which aryl is substituted with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkythio, halo, or --NH.sub.2, orc) thienyl, furyl, pyridyl, benzofuranyl, or benzothienyl;Z is R.sub.2, or --CHWR.sub.2 ;R.sub.2 isa) aryl, optionally substituted with one or two C.sub.1-4 alkyl, C.sub.1-4 alkythio, halo, --NH.sub.2, C.sub.1-4 alkylamino, C.sub.1-4 dialkylamino, or --NHOH,b) C.sub.1-4 alkyl, optionally substituted with fluoro,C) C.sub.1-4 alkoxy,d) C.sub.1-4 alkythio,e) halo, orf) thienyl, furanyl, or pyridyl;W is H, --NH.sub.2, C.sub.1-4 alkylamino, C.sub.1-4 dialkylamino, halo, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, or azaheterocycle;aryl is phenyl, or naphthyl;azaheterocycle is n-morpholinyl, n-piperazinyl, n-pyrrolidinyl, n-imidazolyl, n-pyrrolyl, n-pyrazolyl, n-triazolyl, or n-tetrazolyl;i is 0, 1, or 2;wherein the oxazolidinone is a compound of structure V-A ##STR5##wherein R.sub.1 is methyl, ethyl, cyclopropyl, or dichloromethyl;R.sub.2 is hydrogen or fluoro;and a pharmaceutically acceptable salt.