Patent ID: 6716860
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein:one of A and B is a (C1-C10)-straight or branched alkyl, substituted with pyridine or a (C2-C10)-straight or branched alkenyl or alkynyl, substituted with pyridine; and the other of A and B (C1-C10)-straight or branched alkyl, substituted with phenyl or a (C2-C10)-straight or branched alkenyl or alkynyl, substituted with phenyl; X is O; J is selected from hydrogen, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, or cyclohexylmethyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E; wherein E is a saturated, partially saturated unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in E are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O-[(C1-C6)-straight or branched alkyl], O-[(C3-C6)-straight or branched alkenyl], (CH2)nâ€”N(R4)(R5), (CH2)nâ€”NH(R4)â€”(CH2)nâ€”Z, (CH2)nâ€”N(R4â€”(CH2)nâ€”Z)(R5â€”(CH2)nâ€”Z), (CH2)nâ€”Z, Oâ€”(CH2)nâ€”Z, (CH2)nâ€”Oâ€”Z, Sâ€”(CH2)nâ€”Z, CH&boxH;CHâ€”Z, 1,2-methylenedioxy, C(O)OH, C(O)O-[(C1-C6)-straight or branched alkyl], C(O)Oâ€”(CH2)nâ€”Z or C(O)â€”N(R4)(R5); wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S; wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z; each n is independently 0 to 4; each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, Oâ€”(C1-C3)-straight or branched alkyl, C(O)O-[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or N-[(C1-C3)-straight or branched alkyl]2; K is (C1-C10)-straight or branched alkyl substituted with phenyl or a (C2-C10)-straight or branched alkenyl or alkynyl substituted with phenyl; wherein J and K are optionally and independently substituted with up to 3 substituents selected from halogen, OH, Oâ€”(C1-C6)-alkyl, Oâ€”(CH2)nâ€”Z, NO2, C(O)OH, C(O)â€”Oâ€”(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)nâ€”Z; G, when present, is â€”S(O)2â€”, â€”C(O)â€”, or â€”C(O)â€”C(O)â€”; D is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 carbon ring atoms; wherein 1 to 4 hydrogen atoms in D are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O-[(C1-C6)-straight or branched alkyl], O-[(C3-C6)-straight or branched alkenyl], (CH2)nâ€”NH2, (CH2)nâ€”NH[(C1-C6)-straight or branched alkyl or (C3-C5)-straight or branched alkenyl)], (CH2)nâ€”N[(C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl)]2, 1,2-methylenedioxy, C(O)OH, C(O)O-[(C1-C6)-straight or branched alkyl], C(O)â€”NH2, C(O)â€”NH[(C1-C6)-straight or branched alkyl or (C3-C5)-straight or branched alkenyl)], or C(O)â€”N[(C1-C6)-straight or branched alkyl or (C3-C5)-straight or branched alkenyl)]2; m is 0 to 3; and x is 0 or 1.