Patent ID: 9155472
Filing Date: 2015-10-13
Classification: A61B

Abstract:
1. A method for determination of parameters for evaluating vascular endothelium function in a human subject, the method comprising: (a) measuring and recording as a function of time the intensity of one NADH fluorescence emission wavelength signal emitted from skin tissue cells in a selected location on an upper limb of said subject to obtain a baseline, wherein said NADH fluorescence signal is emitted upon illumination with and absorption of one wavelength of UV exciting light; (b) blocking blood flow in an artery to the upper limb upstream to the selected location, while continuing measuring and recording said intensity as it grows up as a function of time; (c) releasing the block of blood flow while continuing measuring and recording said intensity as it changes as a function of time until obtaining a stationary state; and (d) determining parameters indicative of endothelial function from the course of changes of said intensity, the parameters being one or more selected from the group consisting of: the difference Δl between the maximum level of intensity of NADH fluorescence signal upon blocking blood flow and the minimum level of intensity of NADH fluorescence after releasing the block of blood flow in step (c); the difference Δl the difference Δl