Patent ID: 6372432
Filing Date: 2002-04-16
Classification: C12Q,G01N

Abstract:
A process for the detection in vitro of a cancer or neurodegenerative disease in a subject, comprising (i) taking a sample of blood cells from the subject, wherein said blood cells comprise lymphocytes, macrophages, monocytes or dendritic cells, (ii) preparing nucleic acids from the sample and (iii) hybridizing all or part of the nucleic acids so prepared with at least one nucleic acid library in order to obtain a hybridization profile, wherein the nucleic acid library comprises a plurality of different nucleic acid molecules specific for splicing forms of genes wherein the splicing forms are characteristic of a cancer or neurodegenerative disease, the hybridization profile indicating the presence of blood cells in the sample characteristic of a cancer or neurodegenerative disease, thereby detecting the presence of a cancer or neurodegenerative disease in the subject.