Patent ID: 6569846
Filing Date: 2003-05-27
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I, Iâ€² or Iâ€³whereinA represents OH, OR1, â€”Oâ€”(CH2)nâ€”Y, â€”Sâ€”(CH2)nâ€”Y, â€”NHâ€”(CH2)nâ€”Y, â€”Oâ€”(CH2)2â€”OH, â€”NHâ€”(CH2)2â€”NHâ€”BOC or â€”Nâ€”(CH2â€”CH&boxH;CH2)2 whereinR1 represents Na+, K+, (Ca2+)0.5, (Mg2+)0.5, Li+, NH4++NH3â€”C(CH2OH)3, +NH3â€”CH2â€”(CHOH)4â€”CH2OH, +NH2(CH3)â€”CH2â€”(CHOH)4â€”CH2OH or +N(Cnâ€²H2nâ€²+1)4; R2 represents H, OH or COOR4, wherein R4 is C1-C12 alkyl or C3-C12 cycloalkyl; R3 represents H, OH or C1-C12 alkyl or alkoxy; n is 1, 2, 3, 4, 5 or 6, Y is â€”NRâ€²1Râ€²2 or â€”+NRâ€²1Râ€²2Râ€²3, Xâˆ’ wherein Râ€²1, Râ€²2 and Râ€²3 independently from each other represent â€”CH3 or â€”C2H5; X is F, Cl, Br or I, nâ€² is 1, 2, 3 or 4, and wherein * denotes an asymmetric carbon and â€” â€” â€” represents a single saturated bond or a double unsaturated bond.