Patent ID: 6835745
Filing Date: 2004-12-28
Classification: A61K,C07D

Abstract:
A compound of formula I having the structure, wherein,R1 is phenyl optionally substituted with 1-4 Y groups; R2 is alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, alkylthio of 1-6 carbon atoms, haloalkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, haloalkenyl of 2-7 carbon atoms, haloalkynyl of 2-7 carbon atoms, or phenyl optionally substituted with 1-4 Y groups; R3 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, alkylthio of 1-6 carbon atoms, haloalkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, haloalkenyl of 2-7 carbon atoms, haloalkynyl of 2-7 carbon atoms or phenyl optionally substituted with 1-4 Y groups; X is S; Y is â€”OH, â€”OR4, halogen, â€”CN, â€”CO2H, â€”CO2R4, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, or â€”COR4; Z is â€”CHO, â€”CN, â€”CO2H, â€”CO2R4, â€”CONR4R5, â€”NO2, â€”CH&boxH;NR4, â€”CH&boxH;NOH, or â€”CH&boxH;NOR4; R4 and R5 are each, independently, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, or cycloalkyl of 3-8 carbon atoms; with the proviso that at least one of R2 or R3 is phenyl or phenyl substituted with 1-4 Y groups; or a pharmaceutically acceptable salt thereof.