Patent ID: 6596729
Filing Date: 2003-07-22
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I): or a stereoisomeric form or mixture of stereoisomeric forms or a pharmaceutically acceptable salt form thereof, wherein:A is a ring selected from: P is O or S; Rb, at each occurrence, is independently selected from H, F, Cl, Br, I, CN, C1-4 alkyl, C1-4 alkenyl, C1-4 alkynyl, C1-4 alkyl-Oâ€”, or C1-4 alkyl-NHâ€”, NH2; Rc, at each occurrence, is independently selected from H, C1-4 alkyl, C1-4 alkenyl, and C1-4 alkynyl; W is CR3; X is CR3a; Y is CR3b; Z is CR3c; R1 is selected from the group C1-4 alkyl substituted with 0-9 halogen, cyclopropyl, hydroxymethyl, and CN; R2 is selected from the group methyl substituted with 0-3 R3f, C1-6 alkyl substituted with 0-2 R4, C2-6 haloalkyl, C2-5 alkenyl substituted with 0-2 R4, C2-5 alkynyl substituted with 0-1 R4, C3-6 cycloalkyl substituted with 0-2 R3d, phenyl substituted with 0-2 R3d, and 3-6 membered heterocyclic system containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R3d; R3 is selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, CF3, F, Cl, Br, I, â€”(CH2)tNR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”(CH2)tNHC(O)R7, â€”(CH2)tNHC(O)NR5R5a, â€”NHSO2R10, â€”Sâ€”C1-4alkyl, â€”S(O)C1-4alkyl, â€”S(O)2C1-4alkyl, â€”SO2NR5R5a, and a 5-6 membered heteroaromatic ring containing 1-4 heteroatoms selected from the group O, N, and S; R3a is selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, CF3, F, Cl, Br, I, â€”(CH2)tNR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”(CH2)tNHC(O)R7, â€”(CH2)tNHC(O)NR5R5a, â€”NHSO2R10, â€”Sâ€”C1-4alkyl, â€”S(O)C1-4alkyl, â€”S(O)2C1-4alkyl, â€”SO2NR5R5a, and a 5-6 membered heteroaromatic ring containing 1-4 heteroatoms selected from the group O, N, and S; alternatively, R3 and R3a together form â€”OCH2Oâ€”; R3b is selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, F, Cl, Br, I, â€”NR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”NHC(O)R7, â€”NHC(O)NR5R5a, â€”NHSO2R10, and â€”SO2NR5R5a; alternatively, R3a and R3b together form â€”OCH2Oâ€”; R3C is selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, F, Cl, Br, I, â€”NR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”NHC(O)R7, â€”NHC(O)NR5R5a, â€”NHSO2R10, and â€”SO2NR5R5a; alternatively, R3b and R3c together form â€”OCH2Oâ€”; R3d, at each occurrence, is independently selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, F, Cl, Br, I, â€”NR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”NHC(O)R7, â€”NHC(O)NR5R5a, â€”NHSO2R10, and â€”SO2NR5R5a; R3e, at each occurrence, is independently selected from the group H, C1-4 alkyl, â€”OH, C1-4 alkoxy, OCF3, F, Cl, Br, I, NR5R5a, â€”NO2, â€”CN, â€”C(O)R6, â€”NHC(O)R7, â€”NHC(O)NR5R5a, â€”NHSO2R10, and â€”SO2NR5R5a; R3f, at each occurrence, is independently selected from the group H, F, Cl, Br, I, C1-4 alkyl, CN, â€”OH, â€”Oâ€”R11, OCF3, â€”O(CO)â€”R13, â€”OS(O)2C1-4alkyl, â€”NR12R12a, â€”C(O)R13, â€”NHC(O)R13, â€”SR11, â€”S(O)R11, â€”S(O)2R11, â€”NHSO2R10, and â€”SO2NR12R12a; R4 is selected from the group H, F, Cl, Br, I, C1-6 alkyl substituted with 0-2 R3e, C3-10 carbocycle substituted with 0-2 R3e, phenyl substituted with 0-5 R3e, and a 5-10 membered heterocyclic system containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R3e; R5 and R5a are independently selected from the group H and C1-4 alkyl; alternatively, R5 and R5a, together with the nitrogen to which they are attached, combine to form a 5-6 membered ring containing 0-1 O or N atoms; R6 is selected from the group H, OH, C1-4 alkyl, C1-4 alkoxy, and NR5R5a; R7 is selected from the group H, C1-3 alkyl and C1-3 alkoxy; R8 is selected from the group H, (C1-6 alkyl)carbonyl, C1-6 alkoxy, (C1-4 alkoxy)carbonyl, C6-10 aryloxy, (C6-10 aryl)oxycarbonyl, (C6-10 aryl)methylcarbonyl, (C1-4 alkyl) carbonyloxy(C1-4 alkoxy) carbonyl, C6-10 arylcarbonyloxy (C1-4 alkoxy) carbonyl, C1-6 alkylaminocarbonyl, phenylaminocarbonyl, phenyl (C1-4 alkoxy) carbonyl, and NR5R5a(C1-6 alkyl)carbonyl; R9 is selected from H, C1-4 alkyl, C1-4 alkenyl, C1-4 alkynyl, (C1-6 alkyl)carbonyl, C1-6 alkoxy, (C1-4 alkoxy)carbonyl, C6-10 aryloxy, (C6-10 aryl)oxycarbonyl, (C6-10 aryl)methylcarbonyl, (C1-4 alkyl)carbonyloxy(C1-4 alkoxy) carbonyl, C6-10 arylcarbonyloxy(C1-4 alkoxy) carbonyl, C1-6 alkylaminocarbonyl, phenylaminocarbonyl, phenyl (C1-4 alkoxy) carbonyl, and NR5R5a(C1-6 alkyl)carbonyl; R10 is selected from the group C1-4 alkyl and phenyl; R11 is selected from C1-6 alkyl, C1-6 haloalkyl, C1-6 alkyl substituted with C3-6cycloalkyl substituted with 0-2 R3e, C2-6 alkenyl, C2-6 alkynyl, C3-6 carbocycle substituted with 0-2 R3e; R12 and R12a are independently selected from H, C1-6 alkyl, C1-6 alkyl substituted with C3-6cycloalkyl substituted with 0-2 R3e, and C3-6 carbocycle substituted with 0-2 R3e; alternatively, R12 and R12a can join to form 4-7 membered heterocyclic ring; R13 is selected from the group H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, â€”Oâ€”C2-6 alkenyl, â€”Oâ€”C2-6 alkynyl, NR12R12a, C3-6carbocycle, and â€”Oâ€”C3-6carbocycle; and t is selected from 0 and 1.