Patent ID: 6639105
Filing Date: 2003-10-28
Classification: A61P,C07C,C07D,C07F,C07H

Abstract:
A compound of formula (I): whereinR1 is (CH2)nâ€”(X)â€”(Y); n is 0-4, X is O or S or NH, and Y is an amino acid residue; R3 is H or (C1-C4)alkyl; R4 is H, SCH2CO2(C1-C4)alkyl, Oâ€”(C5-C12)aryl or Sâ€”(C5-C12)aryl where aryl is optionally substituted with halo, OH or (C1-C4)alkyl; R5 is H, OH or absent; R6 is (C1-C4)alkyl or H; and R7 is OH or Si((C1-C4)alkyl)3; or R6 and R7 together are ethylenedioxy; R8 is (C1-C4)alkyl, optionally substituted with OH or halo; the bond represented by - - - - is present or absent; or the pharmaceutically acceptable salts thereof.