Patent ID: 7141594
Filing Date: 2006-11-28
Classification: A61K,C07K

Abstract:
1. A compound represented by the formula: or a pharmaceutically acceptable salt thereof, wherein n represents 0 or 1; R R R wherein A and B each independently represent O, S, SO or SO wherein Z represents O, S or NH; and R wherein Y represents O, S or NH; X represents a bond, O or NR R R R R R R wherein aryl, alone or in combination, is a phenyl or naphthyl radical optionally substituted with one or more substituents selected from the group consisting of alkyl alkoxy, halogen, hydroxy, amino, nitro, cyano, haloalkyl, carboxy, alkoxycarbonyl, cycloalkyl, heterocyclo, alkanoylamino, amido, amidino, alkoxycarbonylamino, N-alkylamidino, alkylamino, dialkylamino, N-alkylamido, N,N-dialkylamido, aralkoxycarbonylamino, alkylthio, alkylsulfinyl, and alkylsulfonyl; wherein cycloalkyl, alone or in combination, is a saturated or partially saturated monocyclic, bicyclic or tricyclic alkyl radical optionally substituted with one or more substituents as defined with respect to aryl; wherein heterocyclo, alone or in combination, is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle radical having at least one nitrogen, oxygen, or sulfur atom ring member, or a corresponding sulfone, sulfoxide, or N-oxide derivative of said heterocycle radical, wherein said heterocycle radical is optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, oxo, aryl, aralkyl, heteroaryl, heteroaralkyl, amidino, N-alkylamidino, alkoxycarbonylamino, and alkylsulfonylamino, is optionally substituted on a secondary nitrogen atom with a substituent selected from the group consisting of hydroxy, alkyl, aralkoxycarbonyl, alkanoyl, heteroaralkyl, phenyl and phenylalkyl, and is optionally substituted on a tertiary nitrogen atom by oxido; and wherein heteroaryl, alone or in combination, is an aromatic heterocycle radical optionally substituted with one or more substituents as defined with respect to aryl or heterocyclo.