Patent ID: 6054448
Filing Date: 2000-04-25
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: ##STR23## in which R.sup.1 is Y or Y--C.sub.1-6 alkyl, where Y is carboxy, tetrazolyl, --SO.sub.2 H, --SO.sub.3 H, --OSO.sub.3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or optionally substituted phenyl-C.sub.1-6 alkyl,R.sup.2, R.sup.3 and R.sup.4 are each hydrogen, hydroxyl, halo, carboxy, C.sub.1-6 alkyl, carboxy-C.sub.1-6 alkyl, optionally substituted phenyl, optionally substituted phenyl-C.sub.1-6 alkyl or C.sub.2-6 alkenyl,X and Z are each hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, optionally substituted phenyl, optionally substituted phenyl-C.sub.1-6 alkyl, optionally substituted naphthylmethyl, optionally substituted anthracenylmethyl, ##STR24## where R"" and R'"" are optionally substituted phenyl, n is 0 or 1 to 3, Q is --O--, --NH--, --S--, --SO--, --SO.sub.2 --, --CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 S--, --CH.sub.2 O --, --CH.sub.2 CH.sub.2 -- or --CONR"""" where R"""" is hydrogen or C.sub.1-6 alkyl, and R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy or hydroxy;provided that one of X and Z is hydrogen, or both of X and Z are hydrogen;or a salt or ester thereof.