Patent ID: 6235907
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
A compound selected from the compounds described and labeled in the specification as 6MG, 6bMG, 7MG, 8MG, 9MG, 10MG, 11MG, 12MG or 13MG;where R.sub.1 is optionally substituted C.sub.1-8 alkyl, C.sub.3-10 cycloalkyl, lower alkyl-C.sub.3-10 cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl, or substituted alklaryl; where R.sub.2 isa)H;b) any optionally substituted alkyl, alkylaryl,c) --C(O)--R.sub.3, ord) --C(R.sub.7).sub.2 --O--R.sub.3 where each R.sub.7 is independent of the other;where R.sub.3 is H, optionally substituted C.sub.1-8 alkyl, cycloalkyl, alkenyl, aryl, substituted aryl, and alkylaryl, or substituted alkylaryl;where R.sub.4 is H, optionally substituted C.sub.1-8 alkyl, C.sub.3-10 cycloalkyl, lower alkyl-C.sub.3-10 cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl, or substituted alkylaryl;where R.sub.5 is H, optionally substituted C.sub.1-8 alkyl, aryl, substituted aryl, or two R.sub.5 groups may be combined to form cyclopentane or cyclohexane, or substituted derivatives thereof;where R.sub.6 is optionally substituted C.sub.1-8 alkyl, lower alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, C.sub.3-10 cycloalkyl, lower alkyl-C.sub.3-10 cycloalkyl, heteroaryl, or substituted heteroaryl,where R.sub.7 is independently H, optionally substituted C.sub.1-8 alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, or two R.sub.7 groups may be combined to form cyclopentane or cyclohexane or substituted derivatives thereof; andwhere R.sub.8 is optionally substituted C.sub.1-8 alkyl, C.sub.3-10 cycloalkyl, lower alkyl-C.sub.3-10 cycloalkyl, alkenyl, aryl, substituted aryl, alkylaryl, or substituted alkylaryl;with the proviso that if the compound is of formula 13MG and R.sub.6 is either methyl, ethyl or substituted alkyl then R.sub.2 is not methyl or hydroxymethyl with the proviso that if the compound is of the formula 6MG, R.sub.2 is not optionally substituted alkyl and with the proviso that if the compound is of the formula 6bMG, R.sub.3 is H and with the proviso that in the case that the compound is one of the remainder of the formulae, R.sub.3 is not H.