Patent ID: 8691841
Filing Date: 2014-04-08
Classification: A61P,C07D

Abstract:
1. A method of treating a patient suffering from anxiety, Alzheimer's disease, Parkinson disease, schizophrenia, memory loss, dementia, cognition deficit, attention deficit, Attention Deficit Hyperactive disorder, memory impairment, depression or an inflammatory disease, comprising administering to the patient an effective amount of a compound according to Formula I: wherein A is X is O or S; R′ is H; R R Ar is phenyl which is unsubstituted or substituted one or more times by alkyl having 1 to 8 C atoms, alkoxy having 1 to 8 C atoms, halogen, dialkylamino wherein the alkyl portions each have 1 to 8 C atoms, amino, cyano, hydroxyl, nitro, halogenated alkyl having 1 to 8 C atoms, halogenated alkoxy having 1 to 8 C atoms, hydroxyalkyl having 1 to 8 C atoms, hydroxyalkoxy having 2 to 8 C atoms, alkenyloxy having 3 to 8 C atoms, alkylthio having 1 to 8 C atoms, alkylsulphinyl having 1 to 8 C atoms, alkylsulphonyl having 1 to 8 C atoms, monoalkylamino having 1 to 8 C atoms, cycloalkylamino wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted, aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted, arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted, cycloalkyloxy wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted, sulfo, sulfonylamino, acylamido, acyloxy or combinations thereof; Het is dihydropyranyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolyl, oxazolyl, pyrrolidinyl, piperidinyl, imidazolyl, imidazolidinyl, or morpholinyl, which is unsubstituted or substituted one or more times by alkyl having 1 to 8 C atoms, alkoxy having 1 to 8 C atoms; or a pharmaceutically acceptable salt thereof, wherein A is attached to the remainder of the compound via its 3 position.