Patent ID: 6348449
Filing Date: 2002-02-19
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of inducing a mucosal immune response against an antigen in an individual comprising the step of administering by topical or lavage administration to mucosal tissue of said individual, a composition comprising bupivacaine and a DNA molecule that comprises a nucleotide sequence that encodes said antigen, said nucleotide sequence operatively linked to regulatory sequences which control the expression of said DNA sequence,wherein: said mucosal tissue is selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal; said DNA molecule is administered free of an infectious agent; and said DNA molecule is taken up by cells, said DNA sequence is expressed in said cells and a mucosal immune response is generated against said antigen.