Patent ID: 6011048
Filing Date: 2000-01-04
Classification: B05D,C07D

Abstract:
A compound having the formula I: ##STR22## wherein X is(1) a bond;m is0 to 5;A is(1) phenyl, or(2) a benzene ring fused to a C.sub.5 -C.sub.10 carbocyclic ring;R.sup.1 is(1) C.sub.1 -C.sub.10 alkyl optionally substituted with up to 5 groups selected from(a) hydroxy,(b) halogen,(c) cyano,(d) QR.sup.2,(e) C.sub.3 -C.sub.8 cycloalkyl,(f) A optionally substituted with up to 5 groups selected from halogen, C.sub.1 -C.sub.10 alkyl and C.sub.1 -C.sub.10 alkoxy,(g) Q'COR.sup.3,(h) S(O).sub.n R.sup.3, where n is 0 to 2,(i) NR.sup.2 SO.sub.2 R.sup.3,(j) NR.sup.2 CO.sub.2 R.sup.2, and(k) CO.sub.2 R.sup.2,(2) C.sub.3 -C.sub.8 cycloalkyl,(3) halogen,(4) cyano,(5) QR.sup.2,(6) S(O).sub.n R.sup.3, where n is 0 to 2,(7) Q'COR.sup.3,(8) NR.sup.2 SO.sub.2 R.sup.3,(9) NR.sup.2 CO.sub.2 R.sup.2,(10) A optionally substituted with up to 5 groups independently selected from(a) R.sup.2,(b) QR.sup.2, and(c) halogen; or(11) CO.sub.2 R.sup.2 ;R.sup.2 is(1) hydrogen,(2) C.sub.1 -C.sub.10 alkyl optionally substituted with up to 5 groups selected from(a) hydroxy,(b) halogen,(c) CO.sub.2 R.sup.4,(d) S(O).sub.n -C.sub.1 -C.sub.10 alkyl, where n is 0 to 2,(e) C.sub.3 -C.sub.8 cycloalkyl,(f) C.sub.1 -C.sub.10 alkoxy, and(g) A optionally substituted with up to 5 groups selected from halogen, C.sub.1 -C.sub.10 alkyl and C.sub.1 -C.sub.10 alkoxy,(3) C.sub.3 -C.sub.8 cycloalkyl, or(4) A optionally substituted with up to 5 groups selected from(a) halogen,(b) nitro,(c) NR.sup.4 R.sup.4,(d) C.sub.1 -C.sub.10 alkoxy,(e) S(O).sub.n -C.sub.1 -C.sub.10 alkyl where n is 0 to 2, and(f) C.sub.1 -C.sub.10 alkyl optionally substituted with up to 5 groups selected from hydroxy, halogen, CO.sub.2 R.sup.4, S(O).sub.n -C.sub.1 -C.sub.10 alkyl, where n is 0 to 2, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.10 alkoxy, and A optionally substituted with up to 5 groups selected from halogen, C.sub.1 -C.sub.10 alkyl and C.sub.1 -C.sub.10 alkoxy;R.sup.3 is(1) R.sup.2 or(2) NR.sup.2 R.sup.2 ;R.sup.4 is(1) H, or(2) C.sub.1 -C.sub.10 alkyl;Q is(1) N(R.sup.2),(2) O or(3) S(O).sub.n, and n is 0 to 2;Q' is(1) N(R.sup.2),(2) O or(3) a bond; ora pharmaceutically acceptable salt thereof or a prodrug thereof.