Patent ID: 6183711
Filing Date: 2001-02-06
Classification: A61K

Abstract:
A method for increasing crystallite size of an apatite, thereby decreasing the angular range of x-rays diffracted therefrom, comprising the steps of:providing a partially alkylated xanthine chosen from the group consisting of compounds of the formula: ##STR2##wherein a hydrogen comprises one of the R1, R2, and R3 substituents, and alkyl groups independently comprise two of the substituents; andcontacting an apatite-forming-system with an amount of the partially alkylated xanthine sufficient to increase the crystallite size of the apatite formed therefrom; andmaintaining an ambient temperature of about 15 to 45.degree. C. for a period sufficient to crystallize apatite, andwherein the apatite forming system comprises a solution of CaCl2 and Na.sub.3 PO.sub.4 at a pH of approximately 9-9.5.