Patent ID: 6495569
Filing Date: 2002-12-17
Classification: A61P,C07D

Abstract:
An imidazolidine compound having the structural formula: or physiologically acceptable salt thereof, wherein:W is a bond, â€”Oâ€”, â€”Sâ€”, or â€”NR12â€”, wherein R12 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; X1 and X2, are each, independently, hydrogen, â€”CN, â€”NO2, â€”SO2R13a, â€”SO2NR13aR13b, â€”C(&boxH;O)â€”R13a, â€”C(&boxH;O)â€”OR13a, or â€”C(&boxH;O)â€”NR13aR13b, wherein R13a and R13b are each, independently, hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl; Y is a bond, â€”(C&boxH;O)â€”, or â€”(CR14aR14)â€”, wherein R14a and R14b are each, independently, hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl; R1 is substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted polycycloalkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R6a, and R6b are each, independently, hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; R7, R8, R9 and R10 are each, independently, hydrogen, hydroxy, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted lower alkanoyloxy substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, halogen, â€”CN, â€”NO2, â€”COOR15a, â€”NR15aR15b, or â€”CONR15aR15b, wherein R5a and R15b are each, independently, hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, or R15a and R15b taken together with the nitrogen atom to which they are bonded a substituted or unsubstituted heterocyclic group containing at least one nitrogen atom; R11a and R11b are each, independently, hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, or R11a and R11b taken together with the nitrogen atom to which they are bonded form a substituted or unsubstituted heterocyclic group containing at least one nitrogen atom; n is an integer form zero to about 4; n is an integer form zero to about 6; and p is an integer form zero to about 2.