Patent ID: 8133695
Filing Date: 2012-03-13
Classification: C07D,G01N,Y10T

Abstract:
1. An assay for screening a test compound, wherein said assay is a binding assay using a fluorescent tracer and a source of a hERG K + channel or fragment thereof, comprising: a) incubating an assay sample comprising the fluorescent tracer, the source of the hERG K b) measuring the amount of the fluorescent tracer bound to the hERG K wherein the fluorescent tracer is a compound of structural formula: or a pharmaceutically acceptable salt thereof, wherein: Ar is a benzo ring; R the ring system comprising W, X, and Y 6-membered ring system wherein Y is —O—, W is C═O, —CH B is a 6-membered N-containing ring; L is —(CR R