Patent ID: 8133723
Filing Date: 2012-03-13
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A DNA plasmid vaccine capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising: a DNA plasmid capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, the consensus influenza antigen comprising consensus hemagglutinin (HA) subtype H1 and a pharmaceutically acceptable excipient; the DNA plasmid comprising a promoter operably linked to a coding sequence that encodes the consensus influenza antigen HA subtype H1, and the DNA plasmid vaccine having a concentration of total DNA plasmid of 1 mg/ml or greater, wherein the coding sequence that encodes the consensus HA subtype H1 comprises SEQ ID NO:9.