Patent ID: 7422738
Filing Date: 2008-09-09
Classification: A61K,C07K

Abstract:
1. A method for treating an animal having a vascularized tumor, comprising simultaneously or sequentially administering to said animal a therapeutically effective combination of at least a first pharmaceutical composition comprising at least a first antibody, or antigen-binding fragment thereof, that targets and binds to an aminophospholipid of an aminophospholipid-protein complex on the luminal surface of blood vessels of the vascularized tumor and at least a second therapeutic agent; wherein said second therapeutic agent is: (a) a chemotherapeutic agent selected from the chemotherapeutic agents listed in Table B; (b) an anti-angiogenic agent selected from the anti-angiogenic agents listed in Table C; (c) an inflammatory cytokine; or (d) a compound that interferes with tubulin activity; and wherein said at least a first antibody, or antigen-binding fragment thereof, kills at least a portion of the endothelial cells of the blood vessels of the vascularized tumor, promotes coagulation in at least a portion of the blood vessels of the vascularized tumor, destroys or occludes at least a portion of the blood vessels of the vascularized tumor, induces necrosis in at least a portion of the tumor, induces tumor regression or induces tumor remission.