Patent ID: 6054478
Filing Date: 2000-04-25
Classification: A61P,C07H,C12P

Abstract:
A compound of the formula (I) ##STR14## and pharmaceutically acceptable salts and solvates or metabolically labile derivatives thereof,wherein R.sup.1 represents hydrogen, halogen, hydroxyl or C.sub.1-4 alkoxy;R.sup.2 represents hydrogen, halogen, hydroxyl, C.sub.1-10 alkoxy, C.sub.1-10 alkylthio, C.sub.1-6 alkoxyC.sub.1-4 alkoxy, arylC.sub.1-6 alkyloxy, arylC.sub.3-6 alkenyloxy, azido, NR.sup.5 COR.sup.5 where each R.sup.5 is independently hydrogen or C.sub.1-6 alkyl, OR.sup.6 (where R.sup.6 is a cyclic ether containing 4 to 8 atoms linked to the oxygen atom via a ring carbon atom adjacent to the ring oxygen atom or a group ##STR15## where Y is oxygen, sulphur or NH, X is either a bond, an oxygen atom or a moiety NR.sup.8 in which R.sup.8 is hydrogen or C.sub.1-6 alkyl, and R.sup.7 is C.sub.1-10 alkyl optionally containing one or two double bonds, aryl, arylC.sub.1-4 alkyl, arylC.sub.2-4 alkenyl, haloC.sub.1-6 alkyl or C.sub.1-6 alkoxyC.sub.1-4 alkyl, and R.sup.3 represents hydrogen, or R.sup.2 and R.sup.3 may together with the carbon atom to which they are attached represent C.dbd.O or C.dbd.NOR.sup.9 where R.sup.9 is C.sub.1-6 alkyl; andR.sup.4 represents hydroxyl, C.sub.1-6 alkoxy or ##STR16## (where R.sup.7 is as defined above); with the proviso that when R.sup.1 represents a hydroxyl group in the axial configuration and R.sup.4 is methoxy then R.sup.2 cannot represent a group in the axial configuration selected from hydroxyl and OCOCH.dbd..sup.z CH--CH.dbd..sup.E CHCH.sub.3.