Patent ID: 7033746
Filing Date: 2006-04-25
Classification: C12N

Abstract:
1. A method of determining whether a human has a carcinoma or an increased likelihood of developing a carcinoma, the method comprising: (a) providing a biological sample from the human, wherein the biological sample comprises a Normal Epithelial Specific-1(NES1) gene, the expression of which is down-regulated during tumorigenic progression and the sequence of which comprises a coding sequence that encodes a polypeptide that is at least 95% identical to SEQ ID NO:1; and (b) examining the expression of the NES1 gene in the biological sample, wherein a decrease in the expression of the NES1 gene relative to expression of a NES1 gene in a control biological sample indicates that the human has a carcinoma or an increased likelihood of developing a carcinoma.