Patent ID: 6680311
Filing Date: 2004-01-20
Classification: A61P,C07D,C07F

Abstract:
A compound of Formula I whereinAr is selected from the group consisting of phenyl, any simple unsubstituted or substituted aromatic, heteroaromatic group, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, NR51R52, OR53, and Formula Arâ€²R1 is selected from the group consisting of halogen and OH; R2 is halogen or OR31, provided that one, but not both, of R1 and R2 is halogen; R3 is a lower alkyl group; R4 is H or OH; R5 is H or OH; or R4 and R5 may be taken together to form a second bond between C13 and C14; R6 is selected from the group consisting of benzyl, hydroxybenzyl, alkoxybenzyl, halohydroxybenzyl, dihalohydroxybenzyl, haloalkoxybenzyl, or dihaloalkoxybenzyl group; R7 is H or a lower alkyl group; R8 is H or a lower alkyl group; R9 is H or a lower alkyl group; R10 is H or a lower alkyl group; R11 is hydrogen; R30 is hydrogen; R31 is R32; R32 is selected from the group consisting of amino acid, carbohydrate, amino sugar, (saccharide)q, and C(O)R33; R33 is R37R38; R37 is (C1-C6)alkyl linker; R38 is COOR39, â€ƒNH2, and amino acid; R39 is H or (C1-C6)alkyl; R40, R41, and R42 are each independently selected from the group consisting of hydrogen, OR43, halo, NH2, NO2, OPO(OR46)2, OR44phenyl, and R45; R43 is C1-C6 alkyl; R44 is C1-C6 alkylene; R45 is selected from the group consisting of an aromatic group and a substituted aromatic group; R46 is selected from the group consisting of H, Na, and â€”C(CH3)3; R50 is hydrogen or R51 is selected from the group consisting of hydrogen and C1-C3 alkyl; R52 is selected from the group consisting of hydrogen and C1-C3 alkyl; R53 is selected from the group consisting of C1-C12 alkyl; R54 is selected from the group consisting of hydrogen, C1-C6 alkyl, simple aromatic, phenyl, COOR57, PO3H, SO3H, SO2R58, NR59R60, NHOR61, NHCH2R61â€², CN, NO2, halogen, OR62, and SR63; R55 is selected from the group consisting of hydrogen, C1-C6 alkyl, simple aromatic, phenyl, COOR57, PO3H, SO3H, SO2R58, NR59R60, NHOR61, NHCH2R61â€², CN, NO2, halogen, OR62, and SR63; R56 is selected from the group consisting of hydrogen, C1-C6 alkyl, simple aromatic, phenyl, COOR57, PO3H, SO3H, SO2R58, NR59R60, NHOR61, NHCH2R61â€², CN, NO2, halogen, OR62, and SR63; R57 is selected from the group consisting of hydrogen and C1-C12 alkyl; R58 is selected from the group consisting of hydrogen and C1-C12 alkyl; R59 is selected from the group consisting of hydrogen, (C1-C6) alkyl and fluorenylmethoxycarbonyl (FMOC); R60 is selected from the group consisting of hydrogen and (C1-C6) alkyl; R61 is selected from the group consisting of hydrogen, OR64, CH2NHR65, NHR65 and fluorenylmethoxycarbonyl (FMOC); R61 is selected from the group consisting of hydrogen, OR64, CH2NHR65, NHR65 and fluorenylmethoxycarbonyl (FMOC); R62 is selected from hydrogen and C1-C6 alkyl; R63 is selected from hydrogen and C1-C6 alkyl; R64 is selected from the group consisting of hydrogen, (C1-C6) alkyl,and CH2NR66R67; R65 is selected from the group consisting of hydrogen, C1-C6 alkyl, NH2, and fluorenylmethoxycarbonyl (FMOC); R66 is selected from the group consisting of hydrogen, C1-C6 alkyl and fluorenylmethoxycarbonyl (FMOC); R67 is selected from the group consisting of hydrogen, C1-C6 alkyl; q is 2, 3, or 4; X is O, NH or alkylamino; and Y is C, O, NH, S, SO, SO2 or alkylamino; or a pharmaceutically acceptable salt or solvate thereof.