Patent ID: 9144414
Filing Date: 2015-09-29
Classification: A61B

Abstract:
1. A method for quantifying drug delivery with a characteristic of measuring a variation of a signal intensity of peripheral vessels using contrast-enhanced ultrasound, comprising: a. producing an ultrasound with a specific mechanical index (MI) by an ultrasound device; b. injecting a specific dose of ultrasound contrast agent into a tested object; c. triggering microbubbles destruction at the target site of the tested object by a ultrasound of high mechanical index; d. monitoring an ultrasound signal intensity of the peripheral vessels in a remote region from the target site using a contrast-enhanced ultrasound of low mechanical index; e. determining, by a processor, an attenuation amount A and an attenuation constant α of the ultrasound signal monitored in the step d based on the microbubble destruction triggered by the sonication in the step c; f. calculating, by the processor, a real time systemic microbubble concentration by using a pharmacokinetic formula C=Ae g. quantifying, by the processor, the drug delivery at a target site based on the real time systemic microbubble concentration.