Patent ID: 7799925
Filing Date: 2010-09-21
Classification: C07D

Abstract:
1. A process for the preparation of substantially optically pure (S)-omeprazole of formula (II), or its pharmaceutically acceptable salts; comprising the steps of: a) treating a racemic mixture of omeprazole of formula (I) with (S)-1,1,2-triphenyl1-1,2-ethanediol of formula (III) in a solvent, whereby the corresponding (S)-omeprazole optical isomer forms an inclusion complex with said (S)-1,1,2-triphenyl-1,2-ethanediol, and isolating from the reaction medium the (S)-omeprazole.2[(S)-1,1,2-triphenyl-1,2-ethanediol] inclusion complex of formula (IV) thus obtained; b) separating (S)-omeprazole from (S)-1,1,2-triphenyl-1,2-ethanediol by destroying the inclusion complex of step a) and recovering (S)-omeprazole in a substantially optically pure form either in neutral form or as a pharmaceutically acceptable salt.