Patent ID: 6632451
Filing Date: 2003-10-14
Classification: A61K,Y10S

Abstract:
A two pulse delivery device for delivering one or more active agents to the gastrointestinal tract of a subject in need of the same, wherein said device comprises:a. a core comprising said one or more active agents and a core material that swells in the presence of an aqueous liquid; b. an inner coat that surrounds said core, wherein said inner coat has an outer surface and comprises water-insolubic hydrophilic particulate matter embedded in a water-insoluble carrier such that in the presence of an aqueous liquid, said particulate matter forms channels in said inner coat that interconnect said core with said outer surface of said inner coat and wherein said inner coat bursts when said core is swollen, thereby releasing said one or more activc agents from said core, wherein said water-insoluble hydrophilic particulate matter and said water-insoluble carrier both include at least one polyssacharide, and wherein said inner coat does not contain an active agent; and c. an outer coat that surrounds said outer surface of said inner coat, wherein said outer coat comprises one or more active agents which may be identical to or different from the one or more active agents that are present in said core, said outer coat comprising at least one excipient for controlling release of said one or more active agents and at least one polysaccharide; wherein release of said one or more active agents from said core and release of said one or more active agents from said outer coat are separated by a predetermined period of time, controlled according to at least a thickness of said inner coat and a relative concentration of said water-insoluble hydrophilic particulate matter of said inner coat.