Patent ID: 6469171
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A method for the preparation of a compound of Formula (II) comprising the step of performing an intramolecular cyclization of a compound of Formula wherein:RA1-A4 are each independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted aryl, optionally substituted heterocyclyl, carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate and cyano; or RA2 and RA3 may optionally together form a bond and RA1 and RA4 are as defined above or together with the carbon atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic group; or RA2 and RA3, together with the carbon atoms to which they are attached form an optionally substituted saturated or unsaturated carbocyclic or heterocyclic group; or RA1RA2Câ€”CRA3RA4 forms an optionally substituted aryl group or aromatic heterocyclic group; Y is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted aryl, optionally substituted heterocyclyl, carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate and cyano; W and X are as defined for Y, or together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group; V represents a halogen or hydrogen atom; Z is â€”(CH2)nâ€”Uâ€”(CH2)oâ€” where U is selected from CH2, NH or a heteroatom, and n and o are independently selected from 0, 1, 2 or 3.