Patent ID: 8859515
Filing Date: 2014-10-14
Classification: A61K,A61P,C12N

Abstract:
1. A method of upregulating a function of and/or the expression of a Tumor Necrosis Factor Receptor 2 (TNFR2) polynucleotide having SEQ ID NO: 1 in human patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 16 to 26 nucleotides in length wherein said at least one oligonueleotide has at least 80% sequence identity to a reverse complement of a polynueleotide comprising 10 to 30 consecutive nucleotides within nucleotides 1 to 413 of SEQ ID NO: 2 and 1 to 413 of SEQ ID NO: 3; thereby upregulating a function of and/or the expression of the Tumor Necrosis Factor Receptor 2 (TNFR2) polynucleotide in patient cells or tissues in vivo or in vitro.