Patent ID: 8895547
Filing Date: 2014-11-25
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula I in which L is R1, —CH(R10)(R11); R10, R11 are each independently H, F, Cl, Br, I, OH, CF  where the aryl radical may be mono- to trisubstituted by F, Cl, Br, I, OH, CF R1 is (C 6 -C 10 )-aryl, (C 3 -C 8 )-cycloalkyl,  where the radical, aryl radical or cycloalkyl radical may be mono- to trisubstituted by F, Cl, Br, I, OH, CF 3 , CHF 2 , CH 2 F, NO 2 , CN, OCF 3 , OCHF 2 , —O(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, NH 2 , NH(C 1 -C 6 )-alkyl, N((C 1 -C 6 )-alkyl) 2 , SO 2 —CH 3 , SO 2 —NH 2 , SO 2 —NH(C 1 -C 6 )-alkyl, SO 2 —N((C 1 -C 6 )-alkyl) 2 , COOH, COO—(C 1 -C 6 )-alkyl, CONH 2 , CONH(C 1 -C 6 )-alkyl, CON((C 1 -C 6 )-alkyl) 2 , SF 5 ; R2 is H, F, (C R3, R4, R5, R13 are each independently  H, F, Cl, Br, I, OH, CF  (C 4- to 12-membered heterocycle, —(C  where the heterocyclyl radical may be mono- to trisubstituted by F, Cl, Br, I, OH, CF  where the (C R6 is H, OH, CF R7, R8 are each independently H, (C R9 is H, OH, OCH and pharmaceutically acceptable salts thereof.