Patent ID: 6822089
Filing Date: 2004-11-23
Classification: C07H,Y02P

Abstract:
A process for preparing a 2â€²-deoxynucleoside comprising the steps of:selecting a ribonucleoside; treating said ribonucleoside with at least one protecting agent for a time and under conditions effective to form a 3â€²-O,5â€²-O-bisprotected ribonucleoside; contacting said 3â€²-O,5â€²-O-bisprotected ribonucleoside with an isomeric mixture of tert-butylphenyl chlorothionoformates for a time and under conditions effective to form isomeric 2â€²-O-tert-butylphenoxythiocarbonyl derivatives of said bisprotected ribonucleoside; and treating said derivatives with a triethylsilyl hydride or poly(alkyl)hydrosiloxane radical reagent and a radical initiator for a time and under conditions effective to form said 2â€²-deoxyribonucleoside.