Patent ID: 7628995
Filing Date: 2009-12-08
Classification: A61K,A61P,C07K

Abstract:
1. An outer membrane vesicle preparation from a Neisserial bacterium that expresses Imp protein wherein expression of the Imp protein is functionally downregulated by disrupting the structure of the Imp protein such that the level of lipopolysaccharide in the outer membrane is decreased compared to a wild-type Neisserial bacterium, wherein at least one of the extracellular loops of the Imp protein is disrupted by inserting a sequence from a different protein into the loop to make a chimeric protein, wherein the chimeric protein comprises at least one part from an Imp protein and at least one part from a Neisserial Hsf protein, wherein the part from a Neisserial Hsf protein is inserted into loop 8 of the Imp protein.