Patent ID: 6180777
Filing Date: 2001-01-30
Classification: C07H,C12Q

Abstract:
In a method for synthesizing a branched or multiply connected macromolecular structure comprising oligonucleotide units, the method of the type wherein separately synthesized oligonucleotide units are assembled into a branched or multiply connected macromolecular structure, an improvement comprising:providing one or more first oligonucleotide units having one or more haloalkylamino groups;providing one or more second oligonucleotide units having one or more thiol or phosphorothioate groups; andcombining the one or more first oligonucleotide units with the one or more second oligonucleotide units so that the haloalkylamino groups react with the thiol or phosphorothioate groups to form thioalkylamino or thiophosphorylalkylamino bridges therebetween.