Patent ID: 7109371
Filing Date: 2006-09-19
Classification: C07C

Abstract:
1. A process for synthesising Latanoprost comprising the steps of: a) preparing a compound of formula (3):  said preparing comprising converting a compound of formula (1):  to a cuprate reagent and performing a 1,4 addition reaction between the cuprate reagent and a compound of formula (2): b) selectively reducing the compound of formula (3) to provide a compound of formula (4): c) dihydroxylating the compound of formula (4) to provide a compound of formula (7): d) reducing the compound of formula (7) to provide a compound of formula (10): e) performing a diol cleavage reaction on the compound of formula (10) to provide a compound formula (13): f) performing a Wittig reaction on the compound of formula (13) to provide a compound of formula (16): g) esterifying the compound of formula (16) to provide a compound of formula (19): h) deprotecting the compound of formula (19) to provide Latanoprost.