Patent ID: 7659076
Filing Date: 2010-02-09
Classification: G01N

Abstract:
1. A process of assay for the presence of an abnormal aggregating form of a protein in a sample, said process comprising the binding of said aggregating form protein by contacting under binding conditions selective for the binding of the abnormal aggregating form of the protein in the presence of a normal non-aggregating form of the protein, a sample containing said aggregating form protein with a binding agent which is a protease-resistant organic polyanionic material having a multiplicity of anionic groups or a protease-resistant organic polycationic material having a multiplicity of cationic groups having a selective binding avidity for said aggregating form of said protein as present in the sample, followed by determining the existence or amount of binding of the protein to the binding agent, wherein the said binding agent is selected from the group consisting of; polyanionic polyglycosides, hexadimethrine bromide, PAMAM dendrimer, poly L-lysine, pDADMAC and polyethyleneimine.