Patent ID: 8940333
Filing Date: 2015-01-27
Classification: A61K,A61P,C08G,Y10S

Abstract:
1. A nanocarrier, comprising: a nanoparticle comprising one or more block copolymers, wherein the block copolymer comprises a hydrophobic block, a hydrophilic block bonded to the hydrophobic block, and one zwitterion, wherein the zwitterion is only bonded to the hydrophobic block, and the zwitterion has one positive charge and one negative charge, wherein the nanoparticle has a hydrophobic interior and hydrophilic surface, wherein the hydrophobic block comprises polycaprolactone (PCL), polyvalerolactone (PVL), poly(lactide-co-glycolide) (PLGA), polylactic acid (PLA), polybutyrolactone (PBL), polyglycolide, or polypropiolactone (PPL), and the hydrophilic block comprises polyethylene glycol (PEG), hyaluronic acid (HA), or poly-γ-glutamic acid (PGA); and an active substance encapsulated in the particle, wherein the nanoparticle has a diameter of about 20-1,000 nm.