Patent ID: 6610732
Filing Date: 2003-08-26
Classification: A61K,A61P,C07C,C07D,Y10S

Abstract:
A method for relieving or preventing constipation in a human constipated patient or cleansing a bowel of a patient which comprises administering to the patient a therapeutically effective amount of the pharmaceutical composition comprising in an amount sufficient for relieving or preventing constipation in a human constipated patient or cleansing a bowel of a human patient a bi-cyclic compound represented by formula (I): where V1 and V2 are carbon atoms; W1 and W2 are â€ƒR3 and R4 are hydrogen atoms or one of them is OH; X1 and X2 are hydrogen, lower alkyl or halogen atom, and at least one of these is a halogen atom; Z is a sulfur atom; R2 a hydrogen atom or alkyl; Y is a saturated or unsaturated C2-10 hydrocarbon chain which is unsubstituted or substituted by oxo, halogen, an alkyl group, hydroxyl or aryl; A is â€”CH2OH, â€”COCH2OH, â€”COOH or its functional derivative; and R1 is a saturated or unsaturated, lower hydrocarbon forming a straight-chain, a branched-chain or a ring, which is unsubstituted or substituted by halogen, oxo, hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkyl, lower cycloalkyloxy, aryl, or aryloxy; lower cycloalkyl; lower cycloalkyloxy; aryl or aryloxy, a bond between C-13 and C-14 position is a double or single bond, and C-15 has a steric configuration of R, S, or a mixture thereof.