Patent ID: 7678787
Filing Date: 2010-03-16
Classification: A61P,C07D

Abstract:
1. A compound having the Formula I: wherein R R A is selected from the group consisting of C═O, CH B is wherein R 6 , R 7 , R 8 , R 9 , R 10 , R 101 , and R 102 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, trihalomethyl, halogen, —C(O) alkyl, hydroxy, hydroxyalkyl, alkyloxyalkyl, —CH(OH)alkyl, —CH(alkoxy)alkyl, formyl, nitro, thioalkyl, —SO 2 alkyl, —SO 2 NHR 11 , —SO 2 N(R 11 ) 2 , —(CH 2 ) p CN, —(CH 2 ) p COOR 12 , —(CH 2 ) p NR 13 R 14 , —(CH 2 ) p CONR 13 R 14 , —CH═NOH, —CH═NO-alkyl, and —C(O)aryl optionally substituted by alkyl; wherein R 5 and R 100 are selected independently from the group consisting of hydrogen, alkyl, trihalomethyl, halogen, —C(O) alkyl, hydroxy, hydroxyalkyl, alkyloxyalkyl, —CH (OH)alkyl, —CH(alkoxy)alkyl, formyl, nitro, thioalkyl, —SO 2 alkyl, —SO 2 NHR 11 , —SO 2 N(R 11 ) 2 , —(CH 2 ) p CN , —(CH 2 ) p COOR 12 , —(CH 2 ) p NR 13 R 14 , —(CH 2 ) p CONR 13 R 14 , —CH═NOH, —CH═NO-alkyl, and —C(O)aryl optionally substituted by alkyl; R R p is 0 or 1; R is a group consisting of wherein R X is selected independently from the group consisting of wherein R R R m is an integer from 1 to 4; q is an integer from 1 to 2; and r is 0 or 1; provided that: if A is C═O, m is 1 or 2, r is 0, R if A is C═O, m is 2, r is 0, R if A is C═O, m is 1 or 2, r is 0, R if A is C═O, m is 1 or 2, r is 0 or 1, R if A is C═O, m is 1, r is 0, R if A is C═O, m is 2, r is 0, R if A is C═O, m is 1 or 2, r is 0, R if A is C═O, m is 1, r is 0 or 1, R if A is C═O, m is 1 or 2, r is 0, R if A is C═O, m is 1 or 2, r is 0, and R a pharmaceutically acceptable salt thereof.