Patent ID: 6407104
Filing Date: 2002-06-18
Classification: A61K,A61P,C07D

Abstract:
A compound represented by the formula (I): wherein R1 is hydrogen atom or a group selected from (a) C6 to C20 alkyl, C6 to C20 alkenyl, C6 to C20 alkynyl, carbocyclic groups, and heterocyclic groups, (b) the groups represented by (a) each substituted independently with at least one group selected from non-interfering substituents, and (c) -(L1)-R6 wherein L1 is a divalent linking group of 1 to 18 atom(s) selected from hydrogen atom(s), nitrogen atom(s), carbon atom(s), oxygen atom(s), and sulfur atom(s), and R6 is a group selected from the groups (a) and (b);R2 is hydrogen atom, or a group containing 1 to 4 non-hydrogen atoms; R3 is -(L2)-(acidic group) wherein L2 is an acid linker having an acid linker length of 1 to 5; R4 and R5 are selected independently from hydrogen atom, non-interfering substituents, carbocyclic groups, carbocyclic groups substituted with a non-interfering substituent(s), heterocyclic groups, and heterocyclic groups substituted by a non-interfering substituent(s); and RA is a group represented by the formula: wherein L7 is a divalent linker group selected from a bond or a divalent group selected from â€”CH2â€”, â€”Oâ€”, â€”Sâ€”, â€”NHâ€”, or â€”COâ€”, R27 and R28 are independently hydrogen atom, C1 to C3 alkyl or a halogen; X and Y are independently an oxygen atom or a sulfur atom; and Z is â€”NH2 or â€”NHNH2; a prodrug thereof, or its pharmaceutically acceptable salt, or its solvate.