Patent ID: 6828278
Filing Date: 2004-12-07
Classification: C07D

Abstract:
A process for preparing a reaction product comprising N-aryl-2-lactam (III), N-cycloalkyl-2-lactam (IV), or a mixture thereof, which comprises the step of contacting a lactone (I) with an aryl amine (II) in the presence of hydrogen gas and a catalyst, the catalyst being optionally supported on a catalyst support, and, optionally, said contacting is performed in the presence of a solvent; wherein: (i) n=0-11; (ii) R1, R2, R3, R4, R5 and R6 taken independently are hydrogen, hydrocarbyl or substituted hydrocarbyl, C1 to C18 unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkyl containing at least one heteroatom, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl; and (iii) R7 is an aromatic group having from 6 to 30 carbons, and R8 is a fully or partially reduced derivative of R7.