Patent ID: 7892547
Filing Date: 2011-02-22
Classification: A61K,A61P,B82Y,Y10S

Abstract:
1. A method for enhancing cellular internalization of a therapeutic or diagnostic agent, comprising administering to a subject: a) a bispecific antibody comprising at least one target binding moiety that binds to a tumor-associated marker selected from the group consisting of carcinoembryonic antigen (CEA), colon-specific antigen-p (CSAp), CD4, CD5, CD8, CD14, CD15, CD19, CD20, CD22, CD40, CD40L, CD74, B7, HLA-DR, EGFR, HER 2/neu, TAG-72, EGP-1, HCG, HCG-beta, PSMA, PSA, VEGF, IL-2 and MAGE and at least one first targetable construct binding moiety that binds to a hapten selected from the group consisting of HSG (histamine succinyl glycine) and In-DTPA; b) a targetable construct comprising a first hapten that is HSG and a second hapten that is In-DTPA, wherein said targetable construct comprises at least one therapeutic or diagnostic agent; and c) an internalization agent comprising a second targetable construct binding moiety that binds to a hapten selected from the group consisting of HSG and In-DTPA and an internalization moiety selected from the group consisting of an anti-CD74 antigen-binding antibody fragment and a folate; wherein said first and second targetable construct binding moieties bind to different haptens and wherein binding of the internalization agent to the second targetable construct enhances internalization of the diagnostic or therapeutic agent.