Patent ID: 6696488
Filing Date: 2004-02-24
Classification: A61K,C07C

Abstract:
A method of treating a subject having or at risk of having a &bgr;-amyloid-associated disease, comprising:administering to a subject having or at risk of having Alzheimer disease a therapeutically effective amount of a compound of Formula I wherein:R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aromatic, heteroaromatic, RO(C&boxH;O), and R7R8N(C&boxH;O), wherein R6, R7, and R8 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aromatic, and heteroaromatic, provided R1 is not bonded to the Formula I nitrogen via a group wherein Z is C and X is O, S, or N;R2 and R3 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aromatic, and heteroaromatic; NHâ€”R4 is peptidyl or R4 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aromatic, and heteroaromatic; and non-hydrogen R1, R2, R3, R4, R6, R7, and R8 can independently be substituted with alkylamino, alkoxy, amino, halide, nitro, sulfate, sulfonamide, sulfoxide, or thiol ether, whereby the &bgr;-amyloid-associated disease is treated.