Patent ID: 7943136
Filing Date: 2011-05-17
Classification: A01K,A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
1. A method for increasing the ratio of normal to abnormal hematopoietic cells in a subject in need thereof, the method comprising: contacting a population of cells expressing a PTH/PTHrP receptor in the subject with an agent that activates the PTH/PTHrP receptor in an amount and for a duration effective to expand a population of hematopoietic stem or progenitor cells, thereby increasing the ratio of normal to abnormal hematopoietic cells in the subject, wherein the subject is a bone marrow donor who has donated bone marrow, is a bone marrow donor who has yet to donate bone marrow, is a bone marrow donor transplant recipient, has hematopoietic progenitor cells under environmental stress, has anemia, has a reduced level of immune cell function compared to a normal subject, has an immune system deficiency, has received chemotherapy or radiation therapy for cancer, will receive chemotherapy or radiation therapy for cancer, has a disorder characterized by a lack of functional immune cells, has received an immuno-suppressive drug, will receive an immuno-suppressive drug, is receiving an immuno-suppressive drug or is a stem cell donor.