Patent ID: 7217701
Filing Date: 2007-05-15
Classification: A61K,A61P

Abstract:
1. A boron compound represented by the formula (I) or nontoxic salts thereof, wherein R 1 is (1) a hydrogen atom; (2) —(CH (3) C1–6 alkyl or C2–6 alkenyl substituted with mono-cyclic C5–6 carboring, wherein the carboring may be substituted with 1 to 5 R (4) —CHR R Cyc1 represents mono- or bi-cyclic C5–10 carboring, wherein the carboring may be substituted with 1 to 5 R wherein the carboring may be substituted with 1 to 4 R 9 ; Cyc3 and Cyc4 independently represents mono- or bi-cyclic C5–10 carboring which may be substituted with 1 to 2 R 7 ; R (a) C1–4 alkyl, (b) C2–4 alkenyl, (c) C1–4 alkoxy, (d) a halogen atom, (e) —CF (f) C1–4 alkylthio, (g) amino, (h) (C1–4 alkyl)amino, (i) di(C1–4 alkyl)amino, (j) formyl, (k) phenyl, (l) phenoxy, (m) hydroxy(C1–2)alkyl, (n) (mono- or bi-cyclic C5–10 carboring)-O—(C1–2)alkyl, (o) C1–4 alkoxycarbonylvinyl, (p) C1–2 alkyl substituted with a group selected from —O—(C1–2 alkylene)-phenyl, wherein phenyl may be substituted with 1 to 3 C1–4 alkoxy, —O—CONH-phenyl, wherein phenyl may be substituted with 1 to 3 C1–4 alkyl, nitro or C1–4 alkoxycarbonyl, or —O—CONH—(C1–4) alkyl, wherein alkyl may be substituted with 1 to 3 C1–4 alkyl, carboxyl or C1–4 alkoxycarbonyl, (q) phenylthio, (r) —CON(C1–4 alkyl) (s) —SO (t) C1–4 alkoxy(C1–2)alkyl, or (u) C1–4 alkoxycarbonyloxy(C1–2)alkyl, in R p represents an integer of 1 to 4; q represents an integer of 1 to 4; and E represents a single bond.