Patent ID: 7408025
Filing Date: 2008-08-05
Classification: A61K,A61P,C07K

Abstract:
1. A compound having the formula (I): and salts thereof; wherein R is: wherein X′ and X″ are independently C═O, C═S, C═NH, C═NR wherein n is 0 or 1; wherein R wherein B is X″R wherein R wherein A is H, NH wherein R wherein when n is 0, then A is additionally: wherein each of R alternatively, wherein B and A together form a 5-7 membered heterocyclic or heteroaryl ring; wherein R wherein X′ and X′″ are independently C═O, C═S, C═NH, C═NR wherein m is 0 or 1; wherein R wherein B′ is X′″R wherein R wherein A′ is unsubstituted alkyl, alkenyl, alkynyl, alkoxy, aryloxy; or alkyl wherein one or more hydrogen atoms is replaced by a substituent group selected from acyl, amino, acylamino, acyloxy, carboalkoxy, carboxy, carboxyamido, cyano, halo, hydroxyl, nitro, thio, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkoxy, aryloxy, sulfinyl, sulfonyl, oxo, guanidino, and formyl; provided that when B′ is H then (X′) m -A′ is other than (a) —C(O)(C (b) —C(O)(C (c) —C(O)C (d) —C(O)C (f) —C(O)C (g) an amino protecting group; and wherein when B′ is H and m is 0, then A′ is other than C wherein R wherein K and K′ together form a C wherein J is hydrido, amino, NHR wherein each of R wherein R alternatively, wherein J together with R alternatively, wherein J, together with both R wherein each of R wherein R wherein each of R