Patent ID: 6680332
Filing Date: 2004-01-20
Classification: C07D

Abstract:
A pharmaceutical composition for treating a disorder responsive to the positive modulation of AMPA receptors in an animal suffering thereof, comprisinga pharmaceutically acceptable carrier or diluent; and an amount effective to positively modulate AMPA receptors in said animal of a compound of Formula I: â€ƒor a pharmaceutically acceptable salt or prodrug thereof, wherein: R1 and R2 are independently hydrogen, C1-10 alkyl, haloalkyl, aryl, fused aryl, a carbocyclic group, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, carbocycloalkyl, hydroxyalkyl, aminoalkyl or thioalkyl; or R1 and R2 are taken together to form a carbocycle; R3 is hydrogen, or C1-10 alkyl; R4 is substituted or unsubstituted aryl, heteroaryl, carbocycle or heterocycle; X is hydrogen, NO2, CN, C1-10 alkyl, haloalkyl, aryl, COR, CO2R or CONRxRy, wherein R, Rx and Ry are independently hydrogen, C1-10 alkyl, haloalkyl, aryl, fused aryl, a carbocyclic group, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, carbocycloalkyl, hydroxyalkyl or aminoalkyl; Y is NH2, NHR, or NHCOR, where R is as defined above; and Z is O or S.