Patent ID: 7824891
Filing Date: 2010-11-02
Classification: A23K,C12P

Abstract:
1. A process for preparing D-pantothenic acid and/or salts thereof which comprises a) culturing at least one bacterium from the Bacillaceae family which produces D-pantothenic acid and in which the biosynthesis of pantothenic acid (pan) and/or isoleucine/valine (ilv) is deregulated and which forms at least 2 g/L of salts of D-pantothenic acid by fermentation in a culture medium, b) passing the D-pantothenate-containing fermentation solution through at least one ion-selective membrane by applying an electric field, wherein the concentration of monovalent ions selected from the group consisting of ammonium, potassium, sodium and chloride, and/or polyvalent ions selected from the group consisting of iron, phosphate and/or sulfate ions is reduced in the D-pantothenate-containing solution, c) adding a calcium base and/or magnesium base to the resulting solution containing free D-pantothenic acid to set the pH to between 3-10, a solution being obtained which contains calcium and/or magnesium pantothenate and d) subjecting the calcium pantothenate- and/or magnesium pantothenate-containing solution to drying and/or formulation wherein no free β-alanine and/or β-alanine salt is fed to the culture medium.