Patent ID: 8535670
Filing Date: 2013-09-17
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method for treating an individual having a colorectal cancer tumor, comprising: (i) determining in a sample of said tumor that a KRAS protein mutation or a nucleic acid encoding a KRAS protein mutation is absent; (ii) selecting an EGFR inhibitor appropriate for the treatment of said tumor; and (iii) administering said EGFR inhibitor to the individual wherein said method comprises determining whether a mutation in codon 12 or 13 of the DNA encoding KRAS is absent; wherein said mutation in codon 12 or 13 encodes a G12A, G12C, G12R, G12S, G12V, G13C, or G13D mutation, wherein said sample of said tumor comprises an epidermal growth factor receptor.