Patent ID: 8815946
Filing Date: 2014-08-26
Classification: A61K,A61P,Y10S

Abstract:
1. A method of inhibiting scar formation comprising topically administering to an ocular wound in a subject a composition comprising an ester of an alpha-ketoalkanoic acid chosen from one or more of ethyl pyruvate, propyl pyruvate, butyl pyruvate, carboxymethyl pyruvate, acetoxymethyl pyruvate, carbethoxymethyl pyruvate, ethoxymethyl pyruvate, 2-oxopropionic acid 3-methoxyphenyl ester, 2-oxopropionic acid 2-ethoxyethyl ester, 2-oxopropionic acid 2-chloroethyl ester, 2-oxopropionic acid isopropyl ester, 2-oxopropionic acid butyl ester, 2-oxopropionic acid p-tolyl ester, and 2-oxopropionic acid tert-butyl ester in an amount effective to inhibit a fibrotic response in the patient.