Patent ID: 8323360
Filing Date: 2012-12-04
Classification: A61K,B01D,C30B

Abstract:
1. A method of crystallization comprising: providing a solution comprising a solute dissolved in a first solvent; providing a dispersion comprising a plurality of nanoparticles in a second solvent, wherein the nanoparticles comprise a surface modified with aliphatic silane groups or polyalkyleneoxidealkoxy silane groups, wherein the first solvent and the second solvent are mutually miscible; combining the solution and the dispersion to form a mixture, wherein the nanoparticles remain dispersed in the mixture and the solute remains dissolved in the mixture at or below a saturation concentration; cooling the mixture such that the solute exceeds the saturation concentration forming crystals; and separating the crystals from the mixture, wherein the nanoparticles remain dispersed in the mixture.