Patent ID: 6331544
Filing Date: 2001-12-18
Classification: A61P,C07D

Abstract:
An indane compound of formula I ##STR13##wherein A and B are independently O or S;D is a methylene group optionally substituted with one or two C.sub.1-4 alkyl groups;Y is CH.sub.2 ;W is a bond, and n+m is 1, 2, 3, 4, 5, or 6;W is CO, SO, or SO.sub.2, n is 2,3,4, or 5 and m is 0, 1, 2, or 3, provided that n+m is not more than 6; orW is O, S, n is 2, 3, 4, or 5 and m is 0, 1, 2, or 3, provided that n+m is not more than 6, andX is N and the dotted line is absent;R.sup.2 -R.sup.5 are independently selected from hydrogen, halogen, cyano, nitro, C.sub.1-6 alk(en/yn)yl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, hydroxy, C.sub.3-8 cycloalk(en)yl, C.sub.3-8, cycloalk(en)yl-C.sub.1-6 alk(en/yn)yl, C.sub.1-6 alkylcarbonyl, phenylcarbonyl, halogen substituted phenylcarbonyl, trifluoromethyl, trifluoromethylsulfonyloxy and C.sub.1-6 alkylsulfonyl;R.sup.6 -R.sup.8 are independently selected from hydrogen, halogen, cyano, nitro, C.sub.1-6 -alk(en/yn)yl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, hydroxy, trifluoromethyl, or C.sub.1-6 alkylsulfonyl; or a pharmaceutically acceptable acid addition salt thereof.