Patent ID: 6818774
Filing Date: 2004-11-16
Classification: A61P,C07D

Abstract:
A compound of formula whereinY is >C&boxH;O or â€”CH2â€”; Z is >C&boxH;O or â€”CH2â€”; R1 is hydrogen or is a group of formula R21-111 each R2 is independently selected from halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy, R3 is selected from â€”(CH2)nâ€”COâ€”NR6R7, â€”(CH2)nâ€”CN, â€”(CH2)pâ€”OR8, â€”(CH2)nâ€”NR6R7, â€”(CH2)nâ€”CF3, â€”(CH2)nâ€”NHâ€”COR9, â€”(CH2)n-tetrahydrofuranyl, â€”(CH2)pâ€”SR8, â€”(CH2)pâ€”SOâ€”R9, or â€”(CH2)nâ€”CSâ€”NR5R6; R4 is hydrogen, C1-C6-alkyl, â€”(CH2)pâ€”OR8, â€”(CH2)pâ€”SR8, or benzyl; R5 is hydrogen, C1-C6-alkyl, â€”(CH2)pâ€”OR8, â€”(CH2)pâ€”SR8, or benzyl; R6 and R7 are each independently selected from hydrogen or C1-C6-alkyl; R8 is hydrogen or C1-C6-alkyl; R9 is C1-C6-alkyl; m is 1, 2 or 3; n is 0, 1 or 2; and p is 1 or 2; or the pharmaceutically acceptable salts thereof.