Patent ID: 6045794
Filing Date: 2000-04-04
Classification: A61K,C07K,C12N

Abstract:
A method of treating a mammal susceptible to or suffering from pre-term labor comprising administering a pharmaceutical composition comprising platelet-activating factor acetyl hydrolase (PAF-AH) enzyme to said mammal in an amount sufficient to supplement endogenous PAF-AH activity and to inactivate pathological amounts of PAF, wherein said PAF-AH enzyme comprises the mature human amino acid sequence of SEQ ID NO: 8 or comprises a PAF-AH polypeptide fragment, variant or variant fragment that hydrolyzes .sup.3 H-acetate from PAF, said PAF-AH enzyme being produced by growing a host cell transformed or transfected with a DNA and isolating said PAF-AH enzyme from said host cell or the medium of its growth, said DNA being selected from the group consisting of (a) a DNA comprising the sequence set out in SEQ ID NO: 7, and (b) a DNA which hybridizes under stringent conditions to the non-coding strand of (a).