Patent ID: 6337338
Filing Date: 2002-01-08
Classification: A61K,A61P

Abstract:
A method for inhibiting the activity of the insulin-like growth factor-1 receptor in a mammalian cell, comprising:administering to said mammalian cell an effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof, whereinR1-R5 are, independently, hydrogen, lower alkyl, substituted lower alkyl, hydroxyl, lower alkoxy, lower acyl, lower alkenyl, lower alkynyl, halo, C(O)NR7R8, COOR9, NR10R11, aryl, aralkyl, cyano or nitro, R6 is quinolinyl or thiazolyl, R7,R8,R9 are, independently, hydrogen, lower alkyl, substituted lower alkyl, aryl, or aralkyl, and R10, R11, are, independently, hydrogen, lower alkyl, substituted lower alkyl, aryl, lower acyl, or aralkyl.