Patent ID: 7262049
Filing Date: 2007-08-28
Classification: A61K,C07K,C12N,C40B

Abstract:
1. A vector system comprising a first vector containing a lentiviral gag gene encoding a lentiviral gag protein, wherein the lentiviral gag gene is operably linked to a promoter and a polyadenylation sequence, wherein said lentiviral gag gene is from a primate immunodeficiency virus or a feline immunodeficiency virus (FIV); a second vector containing an env gene encoding a functional envelope protein, wherein the env gene is operably linked to a promoter and a polyadenylation sequence; a lentiviral pol gene encoding a lentiviral pol protein on the first or second vectors or on at least a third vector, wherein said lentiviral pol gene is operably linked to a promoter and a polyadenylation sequence, wherein said lentiviral pol gene is from a primate immunodeficiency virus or FIV; a packaging vector containing a nucleic acid sequence encoding a desired molecule, where the nucleic acid sequence is operably linked to an inducible promoter and a lentiviral packaging sequence including portions of lentiviral long terminal repeat (LTR) sequences necessary to package the lentiviral RNA into the lentiviral virion; and wherein the envelope protein is encoded by a filovirus envelope gene.