Patent ID: 7173137
Filing Date: 2007-02-06
Classification: C07D

Abstract:
1. A compound represented by the following structure (formula (I)): wherein n is 1 to 5; either R* is —OR 1 and R** is hydrogen, or R* and R** together form a further bond so that a double bond is present between the two carbon atoms carrying R* and R**; R 1 is a radical selected from the group consisting of hydrogen or methyl, or a protecting group; R 2 is a radical selected from the group consisting of hydrogen, methylene and methyl; R 3 is a radical selected from the group consisting of hydrogen, methylene and methyl; R 4 is a radical selected from the group consisting of hydrogen or methyl, or is a protecting group; R 5 is a radical selected from the group consisting of hydrogen, methyl, —CHO, —COOH, —CO 2 Me, —CO 2 (tert-butyl), —CO 2 (iso-propyl), —CO 2 (phenyl), —CO 2 (benzyl), —CONH(furfuryl), —CO 2 (N-benzo-(2R,3S)-3-phenylisoserine), —CON(methyl) 2 , —CON (ethyl) 2 , —CONH(benzyl), —CH═CH 2 , HC≡C—, and —CH 2 R 11 ; R 11 is a radical selected from the group consisting of —OH, —O-Trityl, —O—(C 1 –C 6 alkyl), —(C 1 –C 6 alkyl), —O-benzyl, —O-allyl, —O—COCH 3 , —O—COCH 2 Cl, —O—COCH 2 CH 3 , —O—COCF 3 , —O—COCH(CH 3 ) 2 , —O—CO—C(CH 3 ) 3 , —O—CO(cyclopropane), —OCO(cyclohexane), —O—COCH═CH 12 , —O—CO-Phenyl, —O-(2-furoyl), —O-(N-benzo-(2R,3S)-3-phenylisoserine), —O-cinnamoyl, —O-(acetyl-phenyl), —O-(2-thiophenesulfonyl), —S—(C 1 –C 6 alkyl), —SH, —S-Phenyl, —S-Benzyl, —S-furfuryl, —NH 2 , —N 3 , —NHCOCH 3 , —NHCOCH 2 Cl, —NHCOCH 2 CH 3 , —NHCOCF 3 , —NHCOCH(CH 3 ) 2 , —NHCO—C(CH 3 ) 3 , —NHCO(cyclopropane), —NHCO(cyclohexane), —NHCOCH═CH 2 , —NHCO-Phenyl, —NH(2-furoyl), —NH—(N-benzo-(2R,3S)-3-phenylisoserine), —NH-(cinnamoyl), —NH-(acetyl-phenyl), —NH-(2-thiophenesulfonyl), —F, —Cl, I, —CH 2 CO 2 H and methyl; R 6 is absent, methylene, or oxygen; R 8 is a radical selected from the group represented by the formulas: wherein R 9 is a radical selected from the group consisting of hydrogen and methyl; R 10 is a radical selected from the group represented by the formulas: wherein R or a salt thereof where a salt-forming group is present; where, in the above structures, “a” can be either absent or a single bond; “b” can be either a single or double bond; “c” can be either absent or a single bond; “d” can be either absent or a single bond, and the following provisos pertain: a. if R b. if R c. if R d. if n is 3, R wherein R 9 is hydrogen, and R 10 is represented by the formula then R 1 and R 4 cannot both be simultaneously hydrogen or methyl or acetyl; e. if R f. if R g. if “b” is a double bond then R