Patent ID: 6803378
Filing Date: 2004-10-12
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula wherein:a) R1 is C1-C4 alkyl, carbocyclic radical, aryl-C1-C3 alkylene, aryloxy-C1-C2 alkylene, alkoxy-C1-C2 alkylene, wherein R1 is optionally substituted from 1-3 times with halo, C1-C2 alkyl or C1-C2 alkoxy, or R1 is H; b) R2 is H or C1-C4 alkyl; c) R3 is H, C1-C4 alkyl or phenyl-C0-C2 alkylene which is optionally substituted with 1-3 R5; d) R4 is aryl-C1-C4 alkylene, carbocylic radical, heterocyclic radical, selected from the group consisting of furanyl, pyridiyl, and benzothienyl; aryloxy, aryl-cyclopropylene, aryl-NHC(O)â€”, wherein R4 is optionally substituted with 1-3 R5, provided that, when R1, R2 and R3 are each H, R4 is not unsubstituted phenyl, o-methoxyphenyl or naphthalen-1-yl; e) each R5 is independently selected from H, halo, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 haloalkyl, C1-C4 alkoxy, R6-phenyl, R6-phenoxy, R6-benzyl, R6-benzyloxy, NH2C(O)â€”, alkyl-NHC(O)â€”; f) R6 is H, halo; g) Z is a bond or a substituted or unsubstituted C1-C4 alkylene group; h) B1 is selected from the group consisting of i) R7 is H or C1-C4 alkyl, or a pharmaceutically acceptable salt or solvate thereof.