Patent ID: 6734189
Filing Date: 2004-05-11
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinR1 is the OH or NHOH; R2 is heteroaryl, heteroarylalkyl, heterocyclo or heterocycloalkyl (any of which may be optionally substituted with one or more substituents selected from R6, W and WR6); and R3 is H or alkyl; R4 is alkyl, cycloalkyl, OR9, CO2R14, COR10, S(O)qR10 where q is 0 or 2, CONR7R8, CN or S(O)qNR7R8; two R4 substituents may be attached to the same carbon atom to form C(R4)2, where each R4 is the same or different, or C(R4)2 may represent C&boxH;O; R5 is alkyl, cycloalkyl, aryl, CF3, OR9, COR10, S(O)qR10, CO2R14, CONR7R8, S(O)qNR7R8, halogen, NR10R11 or CN; R6 is OR9, COR10, CO2R15, CONR7R8, NR10R11, S(O)qR10, S(O)qNR7R8, &boxH;O, &boxH;NOR10, succinimido or the group R7 and R8, which may the same or different, are each H, alkyl, cycloalkyl, aryl, arylalkyl, or cycloalkylalkyl; R9 is H, alkyl, CF3, CHF2, CH2F, cycloalkyl, aryl, arylalkyl, or cycloalkylalkyl; R10 is H, alkyl, cycloalkyl, aryl, arylalkyl, or cycloalkylalkyl; R11 is H, alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, COR12, CONR7R8, S(O)qR12 or S(O)qNR7R8; R12 is OR9 or R13; R13 is alkyl, cycloalkyl, aryl, arylalkyl, or cycloalkylalkyl; R14 is H, alkyl or cycloalkyl; R15 is H, alkyl, cycloalkyl, or arylalkyl; X is â€”Oâ€”, â€”S(O)qâ€”, â€”N(R11)â€”, Y is a bond (i.e. is absent); R16 is H, alkyl, cycloalkyl, OR9, CO2R14, COR10, S(O)qR10, CONR7R8, CN or S(O)qNR7R8; R17 is H or alkyl; W is alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclo or heterocycloalkyl;  represents a single or double bond; each k and m is independently 0, 1, 2 or 3; n is 0, 1 or 2; and p is 0, 1 or 2, provided that n+p is 3; or a salt, solvate, hydrate, N-oxide, protected amino, protected carboxy or protected hydroxamic acid thereof.