Patent ID: 8901281
Filing Date: 2014-12-02
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody, or an antigen-binding fragment thereof, comprising: a heavy chain variable region (VH) complementarity determining region 1 (VH CDR1) comprising the amino acid sequence shown in SEQ ID NO: 3; a heavy chain variable region (VH) complementarity determining region 2 (VH CDR2) comprising the amino acid sequence shown in SEQ ID NO: 4; a heavy chain variable region (VH) complementarity determining region 3 (VH CDR3) comprising the amino acid sequence shown in SEQ ID NO: 5; a light chain variable region (VL) complementarity determining region 1 (VL CDR1) comprising the amino acid sequence shown in SEQ ID NO: 6; a light chain variable region (VL) complementarity determining region 2 (VL CDR2) comprising the amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region (VL) complementarity determining region 3 (VL CDR3) comprising the amino acid sequence shown in SEQ ID NO: 8; wherein said antibody or antigen-binding fragment specifically binds a polypeptide consisting of the amino acid sequence of SEQ ID NO: 18.