Patent ID: 8022232
Filing Date: 2011-09-20
Classification: C07C,C07D

Abstract:
1. A method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4-[4-(dimethylamino)-1-(4′fluorophenyl)1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S) or (−)-(R,R)-enantiomer of O,O′-di-p-toluoyl-tartaric acid in a solvent system wherein 1-propanol constitutes at least 50% of the solvent system.