Patent ID: 8614245
Filing Date: 2013-12-24
Classification: C07D

Abstract:
1. A pharmaceutical composition comprising at least one pharmaceutically acceptable additive and/or adjuvant and about 25 μg to about 600 μg of an active ingredient that comprises a crystalline form of (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro-[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine having an X-ray powder diffraction pattern comprising characteristic peaks at 7.8±0.2 degrees 2θ and at 31.6±0.2 degrees 2θ, and wherein the active ingredient comprises (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro-[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine at a diasteromeric excess of about 90% de.