Patent ID: 6489134
Filing Date: 2002-12-03
Classification: A61P,C07C,C07D,C12Q,G01N,Y10S

Abstract:
A method of modulating kinesin motor activity, said method comprising contacting said kinesin motor with a molecule that competitively inhibits said kinesin motor at a microtubule binding site, wherein said molecule is identified according to the following steps:(i) assaying for competitive inhibition of said kinesin motor activity by said molecule at a kinesin ATPase site; (ii) assaying for competitive inhibition of said kinesin motor activity by said molecule at a microtubule binding site; and (iii) identifying said molecule as a kinesin modulator specific to a microtubule binding site when said molecule is a competitive modulator at said microtubule binding site, but not at said ATPase site.