Patent ID: 7115249
Filing Date: 2006-10-03
Classification: A61K,C07B,C07C,Y02P

Abstract:
1. A process for the production of 6-L- 18 F-fluorodopa ( 18 F-FDOPA) which comprises treatment of a solid support-bound FDOPA precursor of formula (I): wherein R 1 and R 2 independently selected from C 1-6 alkyl; P with a source of to give the labelled tracer of formula (II) wherein P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group; optionally followed by: (i) removal of excess fluorinating agent and (ii) removal of any protecting groups; and/or (iii) removal of organic solvent; and/or (iv) formulation of the resultant compound of formula (II) as an aqueous solution.