Patent ID: 7417062
Filing Date: 2008-08-26
Classification: A61P,C07D

Abstract:
1. A compound having the formula: and all pharmaceutically acceptable salts thereof, wherein the subscript n is an integer of from 1 to 3; R R X is a member selected from the group consisting of a bond, CH Ar is a substituted or unsubstituted fused bicyclic aromatic ring system selected from the group consisting of naphthyl, quinolinyl, benzothienyl, isoquinolinyl, benzofuranyl, indolyl, benzothiazolyl, benzimidazolyl, 1,4-benzodioxan, quinoxalinyl, quinazolinyl, cinnolinyl and naphthyridinyl, or is a substituted or unsubstituted linked aromatic ring system selected from the group consisting of biphenyl, phenylthiazolyl, phenylpyrazolyl, pyridylthiazolyl and phenyl substituted with a 5- or 6-membered heteroaryl moiety selected from the group consisting of thiazolyl, thienyl, imidazolyl, pyrazolyl, furyl, oxazolyl, pyridyl, pyrimidinyl and pyrazinyl; and Z is a pyrrolidine ring that is optionally substituted with from one to four R