Patent ID: 7250518
Filing Date: 2007-07-31
Classification: C07D

Abstract:
1. A compound of Formula (1.0.0): —wherein— j is 0 or 1; provided that when j is 0, n must be 2; k is 0 or 1; m is 0, 1, or 2; n is 1 or 2; A is —wherein— “*” indicates the point of attachment of Formula (1.1.3) to the remaining portion of Formula (1.0.0); R —the following:— (1) —H; (2) —(C —where— R —where— R —and— R (3) —(CH —and— (4) phenyl or benzyl, where said phenyl or benzyl is independently substituted by 0 to 3 substituents R R R W is —O—; —S(═O) Y is ═C(R —where— R —Where— R R —or— R —where— r and s are independently 0 to 4 provided that the sum of r+s is at least 1 but not greater than 5; —and— X R R R R —the following:— (a) —H, provided that R —where— p is 0, 1, or 2; and R (b) —(C —and— (c) an aryl or heterocyclyl moiety selected from the group consisting of phenyl; benzyl; furanyl; tetrahydrofuranyl; oxetanyl; thienyl; tetrahydrothienyl; pyrrolyl; pyrrolidinyl; oxazolyl; oxazolidinyl; isoxazolyl; isoxazolidinyl; thiazolyl; thiazolidinyl; isothiazolyl; isothiazolidinyl; pyrazolyl; pyrazolidinyl; oxadiazolyl; thiadiazolyl; imidazolyl; imidazolidinyl; pyridinyl; pyrazinyl; pyrimidinyl; pyridazinyl; piperidinyl; piperazinyl; triazolyl; triazinyl; tetrazolyl; pyranyl; azetidinyl; morpholinyl, parathiazinyl; indolyl; indolinyl; benzo[b]furanyl; 2,3-dihydrobenzofuranyl; 2-H-chromenyl; chromanyl; benzothienyl; 1-H-indazolyl; benzimidazolyl; benzoxazolyl; benzisoxazolyl; benzthiazolyl; quinolinyl; isoquinolinyl; phthalazinyl; quinazolinyl; quinoxalinyl; and purinyl; wherein said aryl and heterocyclyl moieties are each independently substituted with 0 to 2 substituents R —or in the case where B 1 is phenyl— (d) R —wherein— R R B —wherein— said moiety defining B B —wherein— said moiety defining B —or— a pharmaceutically acceptable salt thereof.