Patent ID: 6903068
Filing Date: 2005-06-07
Classification: A61K

Abstract:
1. A method for inducing a cytokine in a cell, the method comprising contacting the cell with an immunological regulator under conditions effective to induce a cytokine, wherein the immunological regulator is selected from the group consisting of a constituent peptide of colostrinin, an active analog thereof, and combinations thereof; wherein the constituent peptide of colostrinin is selected from the group consisting of MQPPPLP (SEQ ID NO:1), LQTPQPLLQVMMEPQGD (SEQ ID NO:2), DQPPDVEKPDLQPFQVQS (SEQ ID KO:3), LFFFLPVGVLP (SEQ ID NO:4), DLEMPVLPVEPFPFV (SEQ ID NO:5), MPQNFYKLPQM (SEQ ID NO:6), VLEMKFPPPPQETVT (SEQ ID NO:7), LKPFPCKVEVFPFP (SEQ ID NO:8), and MHQPPQPLPPTVMFP (SEQ ID NO:34); and wherein the active analog comprises a peptide having an amino acid sequence with at least about 15 percent proline and having at least about 70 percent sequence identity to a constituent peptide of colostrinin selected from the group consisting of MQPPPLP (SEQ ID NO:1), LQTPQPLLQVMMEPQGD (SEQ ID NO:2), DQPPDVEKPDLQPFQVQS (SEQ ID KO:3), LFFFLPVGVLP (SEQ ID NO:4), DLEMPVLPVEPFPFV (SEQ ID NO:5), MPQNFYKLPQM (SEQ ID NO:6), VLEMKFPPPPQETVT (SEQ ID NO:7), LKPFPCKVEVFPFP (SEQ ID NO:8), and MHQPPQPLPPTVMFP (SEQ ID NO:34) and wherein said active analog induces a cytokine.