Patent ID: 8263107
Filing Date: 2012-09-11
Classification: A61L,A61P,C08F,Y10T

Abstract:
1. A method of forming a coating on an implantable device, comprising (a) subjecting a polymer to ozonation to form a peroxy grafted polymer, (b) subjecting the peroxy grafted polymer to a process of reduction or CO (c) attaching a biofunctional compound to the functionalized polymer, and (d) forming a coating on the implantable device comprising the polymer prior to ozonation or forming a coating on the implantable device comprising the functionalized polymer with the biofunctional compound attached thereon, wherein the organic acid is selected from the group consisting of maleic acid, fumaric acid, cinimanic acid, and a combination thereof, wherein the biofunctional compound is an RGD peptide, YIGSR peptide, ANP peptide, elastin, an endothelial progenitor cell (EPC) capturing antibody, an endothelial cell adhesion molecule (ECAM), or combinations thereof.