Patent ID: 6353000
Filing Date: 2002-03-05
Classification: A61K,C07C

Abstract:
A method of treating glaucoma or ocular hypertension in a patient suffering therefrom, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: wherein:n=0 or 2; R1=CO2R, CONR4R5, CH2OR6, or CH2NR7R8; where: R=H or cationic salt moiety, or CO2R forms an ophthalmically acceptable ester moiety; R4, R5=same or different=H or alkyl; R6=H, acyl, or alkyl; R7, R8=same or different=H, acyl, or alkyl; with the proviso that if one of R7, R8=acyl, then the other=H or alkyl; Q=halo; one of T1, T2=H, and the other=OR3; wherein R3 is as defined below; or T1 and T2 together=O; R2, R3=same or different=H, alkyl, or acyl; - - - =single or non-cumulated double bond, with the provisos that a double bond between carbons 4 and 5 may not be of the trans configuration; and that a double bond between carbons 13 and 14 may not be of the cis configuration; X=(CH2)q or (CH2)qO; where q=1-6; and Y=a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; or Xâ€”Y=(CH2)pY1; where p=0-6; and â€ƒwherein: W=CH2, O, S(O)m, NR9, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)m, CH&boxH;N, or CH2NR9; where m=0-2, and R9&boxH;H, alkyl, or acyl; Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and - - - =single or double bond.