Patent ID: 6303291
Filing Date: 2001-10-16
Classification: C12Q,G01N,G16B

Abstract:
A method for comparing a number of primary targets for two or more different drug compositions, said method comprising:(a) determining a number of primary targets of each drug composition according to a method comprising determining the number of expression sets wherein;(i) the expression sets each comprise a plurality of cellular constituents having similar inflection concentrations of the drug composition;(ii) the inflection concentration of the drug composition for a cellular constituent is the level of exposure to the drug composition at which the cellular constituent is increased or decreased by the drug composition in a drug response; and(iii) the drug response comprises measured amounts of the pluralities of cellular constituents in a cell of the cell type at a plurality of levels of exposure of said cell type to the drug composition, wherein each expression set indicates the presence of a different primary target of the drug composition in the cell type, and(b) comparing the number of primary targets determined for each drug composition.