Patent ID: 8008486
Filing Date: 2011-08-30
Classification: A61P,C07D

Abstract:
1. A process for the industrial manufacture of polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-methyl-acetamide comprising the following steps: (i) reacting (5-amino-1H-pyrazol-4-yl)-thiophen-2-yl-methanone with N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-acetamide in a solvent selected from the group consisting of acetic acid, propionic acid, and formic acid at a temperature ranging from 50° C. to the boiling point of the mixture (ii) adding a (C (iii) aging for at least 30 min. at a temperature comprised between 30° C. and 55° C. to initiate the crystallization; and (iv) recovering the crystallized product.