Patent ID: 8664358
Filing Date: 2014-03-04
Classification: G01N,Y02A

Abstract:
1. A set of reagents to measure the levels of biomarkers in a specimen, wherein the biomarkers are selected from the group consisting of the following panels of biomarkers and their measurable fragments: (a) CA-125, CRP, EGF-R, CA-19-9, Apo-AI, Apo-CIII, IL-6, IL-18, MIP-1a, Tenascin C and Myoglobin; (b) CA-125, CRP, EGF-R, CA-19-9, Apo-AI, Apo-CIII, IL-6, MIP-1a, Tenascin C and Myoglobin; (c) CA19-9, CA125, CRP, and EGFR; (d) CA19-9, CA125, CRP, EGFR, ApoCIII, IL-18, and Myoglobin; (e) CA19-9, CA125, CRP, EGFR, IL-6, IL-18, and MIP1a; (f) CA19-9, CA125, CRP, EGFR, IL-18, MIP1a, and Myoglobin; (g) CA19-9, CA125, CRP, EGFR, ApoCIII, IL-18, and Myoglobin; (h) CA19-9, CA125, CRP, EGFR, IL-6, IL-18, and Myoglobin; (i) CA19-9, CA125, CRP, EGFR, ApoA1, MIP1a, and Myoglobin; (j) CA19-9, CA125, CRP, EGFR, ApoCIII, MIP1a, and Myoglobin; and (k) CA19-9, CA125, CRP, EGFR, ApoCIII, IL-6, and MIP1a, the set of reagents having a sensitivity and specificity of about 85% in a population that is symptomatic for ovarian cancer.