Patent ID: 7005276
Filing Date: 2006-02-28
Classification: C07K,C12Q,Y10S

Abstract:
1. An isolated nucleic acid molecule encoding a human Rhesus D antigen contributing to or indicative of the weak D phenotype, said nucleic acid molecule carrying at least one missense mutation, as compared to wild type Rhesus D antigen set forth as SEQ ID NO:41, wherein the missense mutation encodes an amino acid substitution selected from any of the following: in position 3 is from Ser to Cys, in position 10 from Arg to Gln, in position 16 from Trp to Cys, in position 114 from Arg to Trp, in position 149 from Ala to Asp, in position 182 from Ser to Thr, in position 198 from Lys to Asn, in position 201 from Thr to Arg, in position 220 from Trp to Arg, in position 223 from Phe to Val, in position 270 from Val to Gly, in position 276 from Ala to Pro, in position 277 from Gly to Glu, in position 282 from Gly to Asp, in position 294 from Ala to Pro, in position 295 from Met to Ile, in position 307 from Gly to Arg, in position 339 from Gly to Glu, in position 385 from Gly to Ala and in position 393 from Trp to Arg of the amino acid sequence encoded by SEQ ID NO:41 ( FIG. 2 ), or a combination of said substitutions.