Patent ID: 6117839
Filing Date: 2000-09-12
Classification: A61K,A61P,C07K

Abstract:
A synthetic polypeptide having the amino acid sequence identified as SEQ ID NO:1 wherein at least one amino acid has been deleted therefrom provided that amino acids 5 to 14 of SEQ ID NO:1 are not deleted, or a substituted variant thereof in which (i) a non-polar, aliphatic neutral amino acid has been substituted for another non-polar, aliphatic neutral amino acid, (ii) a polar aliphatic neutral amino acid has been substituted for another polar aliphatic neutral amino acid, (iii) a charged acidic amino acid has been substituted for another charged acidic amino acid, (iv) a charged basic amino acid has been substituted for another charged basic amino acid, (v) cysteine has been substituted by alanine, or (vi) a combination of substitutions (i)-(v) has been made, whereby said synthetic polypeptide has bone stimulatory activity in animals and which increases mineral content in bones of animals.