Patent ID: 7351841
Filing Date: 2008-04-01
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula (1) wherein A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl group or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino group, a mono- or di-C 1-10 alkylamino group, a C 1-10 alkoxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkylcarbonylamino group, the mono- or di-C 1-10 alkylamino group and the C 1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group (the C 2-14 aryl group and the C 2-14 aryloxy group may be substituted with one or more C 1-6 alkyl groups (the C 1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C 2-14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group), a C 2-14 aryloxy group (the C 2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group), SO 2 R 5 , SOR 5 or COR 5 (wherein R 5 is a hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group and the C 1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group (the C 2-14 aryl group and the C 2-14 aryloxy group may be substituted with one or more C 1-6 alkyl groups (the C 1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C 2-14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group), a C 2-14 aryloxy group (the C 2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group) or NR 6 R 7 (wherein each of R 6 and R 7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group (the C 2-14 aryl group and the C 2-14 aryloxy group may be substituted with one or more C 1-6 alkyl groups (the C 1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C 2-14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group), or R 6 and R 7 mean, together with each other, —(CH 2 ) m1 -E-(CH 2 ) m2 — (wherein E is an oxygen atom, a sulfur atom, CR 26 R 27 (wherein each of R 26 and R 27 is independently a hydrogen atom, a C 1-10 alkyl group, a C 2-14 aryl group, a C 1-10 alkoxy group, a C 2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR 8 (wherein R 8 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group (the C 2-14 aryl group and the C 2-14 aryloxy group may be substituted with one or more C 2-6 alkyl groups (the C 1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C 2-14 aryl group (the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkyl group (the C 1-10 alkyl group may be substituted with one or more halogen atoms), a C 2-6 alkenyl group, a C 2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C 2-14 aryl group and a C 2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1m2 is 3, 4 or 5)))), B is a sulfur atom, R L X is OR R L L L Y is an oxygen atom, a sulfur atom or NR R