Patent ID: 7547680
Filing Date: 2009-06-16
Classification: A61P,C07H

Abstract:
1. A benzimidazole derivative represented by the general formula: wherein n represents 1 or 2; R R (A) a C (B) a C (C) a C (D) a C (E) a 3 to 10-membered cyclic heterocycloalkyl group; (F) a C (G) a 5 to 10-membered cyclic heteroaryl group; (H)OR (I) SR (J)NR (K) COOR (L)CONR (M) NHCOR in which R 7 to R 14 independently represents a hydrogen atom, or any of the following substituents (N) to (P) which may have the same or different 1 to 3 groups selected from a substituent group α, or any of the following substituents (Q) to (V) which may have the same or different 1 to 3 groups selected from substituent groups α and β (N) a C (O) a C (P) a C (Q) a C (R) a 3 to 10-membered cyclic heterocycloalkyl group; (S) a quaternary salt of a 3 to 10-membered cyclic nitrogen-containing heterocycloalkyl group; (T) a C (U) a 5 to 10-membered cyclic heteroaryl group; (V) a quaternary salt of a 5 to 10-membered cyclic nitrogen-containing heteroaryl group; R R R and with the proviso that at least one of R 1 , R 2 and R 3 does not represent a group selected from a hydrogen atom, a halogen atom, a hydroxy group, a C 1-6 alkoxy group, NH 2 and COOH wherein Substituent group α is: wherein Substituent group α is: (a) a halogen atom; (b) a cyano group; any of the following substituents (c) to (h) which may have the same or different 1 to 3 groups selected from a substituent group γ, or any of the following substituents (i) to (v): (c) a C (d) a 3 to 10-membered cyclic heterocycloalkyl group; (e) a quaternary salt of a 3 to 10-membered cyclic nitrogen-containing heterocycloalkyl group; (f) a C (g) a 5 to 10-membered cyclic heteroaryl group; (h) a quaternary salt of a 5 to 10-membered cyclic nitrogen-containing heteroaryl group; (i) OR (j) SR (k) NR (l) N (m) COOR (o) NHCOR (p) NHC(═NH)—NH (q) C(═NH)—NH (r) NR (s)NR (t) SO (u) CONR (v) SO in which R D-F independently represent any of the following substituents (y1) to (y11) which may have the same or different 1 to 3 groups selected from a substituent group γ; R or any of the following substituents (y1) to (y11) which may have the same or different 1 to 3 groups selected from a substituent group γ; R (y1) a C (y2) a C (y3) a C (y4) a C (y5) a 3 to 10-membered cyclic heterocycloalkyl group; (y6) a C (y7) a 5 to 10-membered cyclic heteroaryl group; (y8) a C (y9) a 3 to 10-membered cyclic heterocycloalkyl-C (y10) a C (y11) a 5 to 10-membered cyclic heteroaryl-C wherein Substituent group β is: any of the following substituents (z1) to (z3) which may have the same or different 1 to 3 groups selected from a substituent group γ; substituent group γ: (z1) a C (z2) a C (z3) a C wherein Substituent group γ is: (1) a halogen atom; (2) a nitro group; (3) a cyano group; (4)OR (5)SR (6) NR (7) N (8) COR (9) COOR (10) OCOR (11) NHCOR (12) NHC(═NH)—NH (13) C(═NH)—NH (14)NR (15)NR (16)CONR (17)SO (18) a hydroxy(C (19) a 5 to 10-membered cyclic nitrogen-containing heteroaryl group wherein R