Patent ID: 8715721
Filing Date: 2014-05-06
Classification: A61K,A61P

Abstract:
1. A once-a-day oral controlled-release dosage form comprising hydrocodone or a pharmaceutically acceptable salt thereof and a controlled release material comprising a hydrophobic and/or hydrophilic material, wherein the controlled release material is included in an effective amount such that the dosage form provides a rate of absorption during the time period from T an in-vitro release rate of hydrocodone or a pharmaceutically acceptable salt thereof, when measured by the USP Basket Method at 100 rpm in 900 ml aqueous buffer at a pH of between 1.6 and 7.2 at 37° C., of from 0% to about 35% at 1 hour, from about 10% to about 70% at 4 hours, from about 20% to about 75% at 8 hours, from about 30% to about 80% at 12 hours, from about 40% to about 90% at 18 hours, and greater than about 60% at 24 hours.