Patent ID: 7306734
Filing Date: 2007-12-11
Classification: B01D,B01J,G01N

Abstract:
1. In a method of separating enantiomeric isomers by simulated moving bed chromatography, the improvement comprising bringing the enantiomeric isomers into contact with a filler comprising a porous carrier carrying a polysaccharide derivative thereon in an amount of 25 to 30% by mass, the filler having a TS coefficient in a range of 0.645 to 0.796, the TS coefficient being determined by formula (I) and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is fitted in a column tube by a slurry filling method: wherein: TS is tetrakis (trimethylsilyl) silane; Vc (cm FR (ml/min.) is a flow velocity; t(TS) (min.) is an elution time for tetrakis (trimethylsilyl) silane; and t(blank) (min.) is an elution time for TS in the state where the column is not connected, wherein the productivity is from 1.89 to 2.15 kg-rac./kg-CSP/day.