Patent ID: 8697065
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method for treating a subject with, or suspected of having, cancer comprising: administering a composition to a subject with cancer or suspected of having cancer, wherein said composition comprises a variant of ribonuclease one (human RNase I) of SEQ ID NO:2 conjugated to a cell- or disease-specific monoclonal immunoglobulin, wherein said variant ribonuclease has the biological property of cell killing or RNA degradation and wherein said variant ribonuclease differs from SEQ ID NO:2 at positions 38 and 39, such that position 38 is arginine, as well as: a) two or more of changes in region 86-91, b) a change to a cysteine at a position 1-6; c) a change to a cysteine at a position 116-121; and d) a change consisting of one additional amino acid change that does not remove cell killing or RNA degradation activity.