Patent ID: 8236308
Filing Date: 2012-08-07
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical composition for the treatment of a human patient, comprising a bispecific single chain antibody which comprises (i) a first binding domain binding to an epitope of human and non-chimpanzee primate CD3, and (ii) a second binding domain binding to a cell surface antigen, wherein the bispecific single chain antibody comprises an amino acid sequence selected from the group consisting of: (a) the amino acid sequence as shown in SEQ ID NOs. 70, 72, 78 or 80; (b) the amino acid sequence encoded by a nucleic acid sequence as shown in SEQ ID NOs. 69, 71, 77 or 79; and (c) the amino acid sequence encoded by a nucleic acid sequence which is degenerate as a result of the genetic code to the nucleotide sequence of (b).