Patent ID: 6747053
Filing Date: 2004-06-08
Classification: A61P,C07D,Y02A

Abstract:
Compounds of formula (I) whereinR1 is heteroaryl, (CRâ€²Râ€³)mâ€”COâ€”Ra or â€”S(O)pâ€”Ra; wherein: Râ€² and Râ€³ are independently hydrogen or lower alkyl; m is zero or one; p is one or two; Ra is heteroaryl, heteroaryl-lower-alkyl, or heteroaryl-lower-alkoxy wherein the heteroaryl in each of the preceding is selected from the group consisting of indolyl, pyridyl, quinolinyl, isoquinolinyl, N-oxo-quinolinyl, N-oxo-isoquinolinyl, naphthyridinyl, pyrazolyl, indazolyl, furo[2,3-b]pyridinyl, furo[2,3-c]pyridinyl, furo[3,2-c]pyridinyl, furo[3,2-b]pyridinyl, 1H-pyrrolo[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, 1H-pyrrolo[3,2-c]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, 1H-pyrazolo[3,4-b]pyridine, 1H-pyrazolo[3,4-c]pyridine, 1H-pyrazolo[4,3-b]pyridine, 1H-pyrazolo[4,3-c]pyridine, benzothiazolyl, azaindolyl, imidazo[2,1-b]benzothiazolyl and indolizinyl, each optionally substituted; R2 is hydrogen or lower-alkyl R3 is hydrogen or lower-alkyl R4 is hydrogen or lower-alkyl, R5 is hydrogen, lower-alkyl, heteroalkyl, alkoxyacylalkyl, cycloalkyl, cycloalkyl-loweralkyl, aryl aralkyl, heteroaryl or heteroaryl-loweralkyl; R6 is hydrogen or alkyl; and n is an integer from one to three; and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof.