Patent ID: 8304539
Filing Date: 2012-11-06
Classification: A61P,C07D

Abstract:
1. A compound according to formula I an enantiomer, diastereomer, tautomer, or a pharmaceutically-acceptable salt thereof, wherein: Z is selected from heterocyclo, heteroaryl, and cyano; J R —OC(═O)R 12 , —NR 12 C(═O)R 13 , —NR 12 C(O)OR 13 , —NR 12 C(S)OR 13 , —S(O) p R 16 , NR 12 SO 2 R 16 , dialkylaminoalkoxy, alkoxyalkyloxyalkyloxy, SO 2 NR 12 R 13 , cycloalkyl, cycloalkenyl, cycloalkynyl, heterocyclo, aryl, and heteroaryl; and/or (ii) where possible, together with the atoms to which they are attached, each one of R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 is taken together with any one of R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 located on an adjacent atom to form a fused ring; R R R R p is 0, 1 or 2.