Patent ID: 6121480
Filing Date: 2000-09-19
Classification: C07C

Abstract:
A method for producing unsymmetrically substituted biphenyls of the general formula ##STR12## where R=H, alkyl, alkoxy, F, Cl or 4-phenylmethoxy by the palladium-catalysed coupling of an aryl Grignard compound of the general formula ##STR13## where X=Cl, Br or I; R=H, alkyl, alkoxy, F, Cl or 4-phenylmethoxy and the ring bearing the R substituent is optionally further substituted, with optionally substituted bromobenzonitrile comprising adding the Grignard compound to the bromobenzonitrile slowly at 10-100.degree. C., over a time span of at least 30 minutes, said palladium catalyst being present at a concentration of 0.1 to 20.0% molar based on the benzonitrile.