Patent ID: 6828323
Filing Date: 2004-12-07
Classification: A61L,A61P,C07D

Abstract:
A non-toxic composition comprising:(a) a member selected from the group consisting of biologically active protein derived from blood, blood, and blood constituents other than water; and (b) a water soluble blood product additive photosensitizer for inactivating microorganisms suitable for administration to a patient having the structure: wherein R1, R2, R3, R4, R5 and R6 are, independently from one another, selected from the group consisting of hydrogen; â€”OH; â€”NH2; â€”SO4; â€”PO4; â€”Cl; â€”Br; â€”I; straight chain or cyclic saccharides with 5 or 6 carbon atoms; ascorbate; amino acid groups; optionally substituted alkyl, alkenyl, alkynyl or aryl groups with from 1 to 20 carbon atoms said alkyl, alkenyl, alkynyl or aryl groups optionally substituted with one or more of â€”Oâ€”, â€”Sâ€”, â€”OH, â€”SH, â€”COH, â€”CO2H, â€”NH2, â€”SO4, â€”PO4, â€”F, â€”Cl, â€”Br, â€”I; and â€”NRaâ€”(CRbRc)nâ€”X wherein n is an integer from 0 to 20, X is a halogen selected from the group consisting of chlorine, bromine and iodine, Ra, Rb and Rc are, independently of each other, selected from the group consisting of hydrogen; straight chain or cyclic saccharides with 5 or 6 carbon atoms; ascorbate; amino acid groups; optionally substituted alkyl, alkenyl, alkynyl or aryl groups with from 1 to 20 carbon atoms said alkyl, alkenyl, alkynyl or aryl groups optionally substituted with one or more of â€”Oâ€”, â€”Sâ€”, â€”OH, â€”SH, â€”COH, â€”CO2H, â€”NH2, â€”SO4, â€”PO4, â€”F, â€”Cl, â€”Br, â€”I; and salts of the foregoing; provided that R1, R4, R5 are not all methyl groups when all of R2, R3 and R6 are hydrogens, and provided that R1 is neither H nor â€”OH nor a straight chain alkyl group where the second carbon of the chain is substituted with â€”OH or &boxH;O except that the compound may be