Patent ID: 6277364
Filing Date: 2001-08-21
Classification: A61K,A61Q,C08G,Y10S

Abstract:
A method for protecting the skin of a mamnmal, comprising applying to the skin of a mammal an effective amount of a polyurethane of Formula (I) in the absence of a pharmacologically active agent:H-[-(YR).sub.m --OC(O)NH-X-NHC(O)].sub.n --(YR).sub.m --OC(O)NH--X--NHC(O)O--(RY).sub.m --[C(O)NH--X--NHC(O)O--(RY).sub.m -]n -H (I)wherein:X is an alkylene or alkenylene radical containing from 1 to about 20 carbon atoms, or a cycloalkylene or cycloalkenylene radical containing from about 5 to 20 carbon atoms, or a mononuclear or fused ring arylene radical containing from about 6 to about 10 carbon atoms, unsubstituted or substituted with one or more lower alkyl, lower alkoxy, lower alkoxy-substituted lower alkyl, nitro or amino groups or halogen atoms;Y is oxygen, sulfur or --NR'--, where R' is hydrogen or lower alkyl;R is the same or different, and is chosen from alkylene, alkenylene, ---SiR.sup.2 R.sup.3 --, and --CR.sup.2 R.sup.3 NR.sup.4 --CR.sup.2 R.sup.3 --, wherein R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or lower alkyl;m is an integer selected to provide a (YR) moiety having a molecular weight of from about 40 to about 10,000; andn and n' are the same or a different integer from 0-30 inclusive, correlated with m so as to provide a polyurethane compound having a molecular weight of up to about 200,000;wherein said polyurethane forms a barrier on the surface of the skin and is absorbed into the outer layer of the skin.