Patent ID: 6521635
Filing Date: 2003-02-18
Classification: A61K,G01N

Abstract:
A method of inhibiting a MXR transporter in a cell overexpressing a MXR gene but not overexpressing a Pgp gene comprising:contacting said cell, which overexpresses a MXR gene, but does not overexpress a Pgp gene, with a compound of formula (I): wherein R0 represents a hydrogen or halogen atom, or a C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, amino, or nitro group; R1 represents a hydrogen or a halogen atom, or a C1-4 alkyl, C1-4 alkoxy, or C1-4 alkylthio group; R2 represents a hydrogen or a C1-4 alkyl group; A represents an oxygen or a sulfur atom or a bond; B represents an unsubstituted C1-4 alkylene chain R3 and R4 each independently represents a C1-4 alkoxy group; or salts and solvates thereof; and wherein said compound of formula (I) is present in an amount sufficient to inhibit a MXR transporter.