Patent ID: 9175047
Filing Date: 2015-11-03
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A peptidomimetic macrocycle-comprising a crosslinker linking the α-positions of at least two amino acids, and an amino acid sequence that is at least 80% identical to the amino acid sequence NleDVN$TLL$LKVAibAQ (SEQ ID NO: 113) and, wherein the peptidomimetic macrocycle has a structure of Formula (I): wherein: each A, C, D, and E is independently a natural or non-natural amino acid; each B is independently a natural or non-natural amino acid, amino acid analog, or each R each L is independently a macrocycle-forming linker of the formula -L each L each R each K is independently O, S, SO, SO each R each R each R each R amino acids represented as $ are alpha-Me S5-pentenyl-alanine olefin amino acids; each v and w are independently integers from 1-1000; u is an integer from 1-10; each x, y and z are independently integers from 0-10; and each n is independently an integer from 1-5.