Patent ID: 6436973
Filing Date: 2002-08-20
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I): in which:X is chosen from the following groups: i) â€”NH2 R1 and R2 are independently chosen from the following groups: i) a hydrogen atom ii) a lower alkyl group iii a lower alkyl group substituted with a halogen atom iv) CF3 v) a halogen atom; n1 varies from 1 to 4 n2 varies from 0 to 10 R3 is chosen from the following groups: i) a hydrogen atom Y is chosen from the following groups: i) â€”Oâ€”ii) â€”CH2â€”iii) â€”Sâ€”iv) â€”OCH2â€”v) â€”SCH2â€”Ar is chosen from the following groups: i) a phenyl group which is unsubstituted or which is mono- or polysubstituted with substituents chosen from halogen atoms and CF3, lower alkyl, lower alkoxy, NH2, NO2, CN, OH, CO2H, OPh, OCH2Ph, SMe, SEt, Ph, CH2Ph and NHCOR7 groups where R7 is a lower alkyl group, R4 and R5 are independently chosen from the following groups: an unsubstituted phenyl group, a phenyl group which is mono- or polysubstituted with substituents chosen from halogen atoms and CF3, NO2, CN, OH, lower alkyl and lower alkoxy groups; R6 represents a lower alkyl group or a phenyl group; excluding the compounds of formula I in which X is â€”NH2, R1 and R2 are each a hydrogen atom, n1=1, n2=0, R3 is a hydrogen atom or formula (v), Y is a group â€”OCH2â€” or â€”SCH2â€” and Ar is a phenyl group, as well as their isomers, diastereoisomers and enantiomers and their pharmaceutically acceptable salts.