Patent ID: 6433185
Filing Date: 2002-08-13
Classification: C07C,C07D

Abstract:
A compound of formula: in whichR1 is a phenyl, a naphthyl, a tetrahydronaphthyl, a quinolyl or an isoquinolyl, the said rings being unsubstituted or substituted one or more times with R10; R2 is a phenyl which is unsubstituted or substituted one or more times with R11, a phenyl(C1-C4)alkyl which is unsubstituted or substituted one or more times on the phenyl with R11, a naphthyl which is unsubstituted or substituted one or more times with R11, a cyclohexyl which is unsubstituted or substituted one or more times with R11; or R2 and R9 are linked together and constitute a (C3-C5)alkylene which is unsubstituted or substituted with R12 or a (C2-C4)alkylene which is interrupted with an oxygen atom or a sulphur atom and is unsubstituted or substituted with R12; or R2 and R9, together with the carbon atom and the nitrogen atom to which they are attached, constitute tetrahydroisoquinoline which is unsubstituted or substituted one or more times with a halogen, a hydroxyl, a (C1-C4)alkyl, a (C1-C4)alkoxy or a benzyloxy; R3 is hydrogen or a hydroxyl; R4 and R5 are each independently hydrogen or a (C1-C4)alkyl; or R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: 1-pyrrolidinyl, 1-piperidyl, perhydro-1-azepinyl, 4-morpholinyl, 4-oxo-1-piperidyl, dihydro-1-pyrrolyl or dihydro-2-imidazolyl, the said heterocyclic radicals being unsubstituted or substituted one or more times with R13; R9 is hydrogen, a (C1-C4)alkyl or a phenyl(C1-C4)alkyl which is unsubstituted or substituted on the phenyl one or more times with R11; R10 is a halogen, a (C1-C4)alkyl, a (C1-C4)alkoxy, a hydroxyl, an amino, a (C1-C4)alkylamino or a di(C1-C4)alkylamino; R11 is a halogen, a (C1-C4)alkyl, a trifluoromethyl, a phenyl, a hydroxyl, a (C1-C4)alkoxy or a benzyloxy; or R11 is in the ortho position to the phenyl representing R2 and forms with R3 a methylene group or an ethylene group; or R11 is in the ortho position to the phenyl representing R2 and forms with R9 a methylene group or an ethylene group; R12 is a halogen, a (C1-C4)alkyl, a hydroxyl, a (C1-C4)alkoxy, a benzyloxy, an oxo, a phenyl, an acetyloxy or a trifluoroacetyloxy; R16 is hydrogen or a methyl, or R16 forms with R9 a methylene group; R17 is hydrogen or a methyl; C* is an asymmetric carbon atom; as well as the salts thereof with inorganic or organic acids.