Patent ID: 9163240
Filing Date: 2015-10-20
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method of identifying a female human subject at increased risk of low progesterone levels and/or poor fetal viability during pregnancy comprising: a. obtaining a biological sample from the female human subject; b. extracting genomic DNA from the biological sample; c. hybridizing primers to the genomic DNA to form a primer:DNA complex; d. amplifying the primer:DNA complex using polymerase chain reaction to amplify a portion of exon 1 of the SR-BI gene; e. sequencing the amplified DNA to detect the presence or absence of rs4238001 single nucleotide polymorphism (SNP); f. identifying the female human subject as having an increased risk of low progesterone levels and/or poor fetal viability during pregnancy based on the detection of an A allele at rs4238001 SNP; and g. treating the female human subject with progesterone.