Patent ID: 6200999
Filing Date: 2001-03-13
Classification: A61K,A61P,C07D

Abstract:
A (3-alkoxyisoxazol-4-yl)-substituted 2-amino carboxylic acid derivative having general Formula I or II ##STR15##wherein R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, cycloalk(en)yl, cycloalk(en)yl-C.sub.1-6 alk(en/yn)yl or phenyl-C.sub.1-6 alk(en/yn)yl, the phenyl group being optionally substituted with CF.sub.3, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;A is a bond or a spacer group selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene, and cycloalkylene;B is a group --CR.sub.a (NR.sub.b R.sub.c)--COOR.sub.5 wherein R.sub.a -R.sub.c are independently hydrogen or C.sub.1-6 alkyl, and R.sub.5 is defined as R.sub.1 or pivaloyloxymethyl, or B is a group of Formula III ##STR16##wherein R.sub.2, R.sub.3 and R.sub.4 are independently selected from the group consisting ofa) hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, cycloalk(en)yl, cycloalk(en)yl-C.sub.1-6 alk(en/yn)yl, phenyl-C.sub.1-6 alkyl, thienyl-C.sub.1-6 -alkyl, andb) C.sub.1-6 alkyl, C.sub.2-6 alkenyl and C.sub.2-6 alkynyl in which one or more carbon atoms are replaced by N, O, and/or S, orR.sub.3 and R.sub.4 are connected, thereby forming a C.sub.2 -C.sub.6 alkylene, C.sub.2 -C.sub.6 alkenylene or C.sub.2 -C.sub.6 alkynylene group, orR.sub.4 and R.sub.2 are connected in order to form a C.sub.1 -C.sub.3 alkylene, C.sub.2 -C.sub.3 alkenylene or C.sub.2 -C.sub.3 alkynylene group optionally mono- or di-substituted with hydroxy or methyl, or to form CH.sub.2 --O--CH.sub.2 ;E is COOR.sub.6, where R.sub.6 is defined as R.sub.5 ;X is O; Y is O or S; or apharmaceutically acceptable salt thereof.