Patent ID: 8834893
Filing Date: 2014-09-16
Classification: A61K,C07K,C12N

Abstract:
1. An isolated nucleic acid comprising a 5′ untranslated region, an NS3 protein coding region, an NS4A protein coding region, an NS4B protein coding region, an NS5A protein coding region, an NS5B protein coding region, and a 3′ untranslated region of a hepatitis C virus genome, wherein the nucleic acid has nucleotide substitutions causing one or more amino acid substitutions selected from the group consisting of F1548L, C1615W, T1652N, A2196T, A2218S, H2223Q, Q2281 R, K2520N, and G2374S, as defined using the amino acid sequence shown in SEQ ID NO: 5 or 6 as a reference sequence, in the NS3 protein coding region, the NS 5 A protein coding region, or the NS5B protein coding region.