Patent ID: 6716820
Filing Date: 2004-04-06
Classification: C07H

Abstract:
A compound represented by the formula or a pharmaceutically acceptable salts, esters or prodrug thereof whereinA is selected from: (a) â€”OH; (b) â€”ORp, where Rp is a hydroxy protecting group; (c) â€”R1, where R1 is selected from: 1. aryl; 2. substituted aryl; 3. heteroaryl; or 4. substituted heteroaryl; (d) â€”OR1, where R1 is as previously defined; (e) â€”R2, where R2 is selected from: 1. hydrogen; 2. halogen; 3. C1-C6 alkyl containing 0, 1, 2, or 3 heteroatoms selected O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; 4. C2-C6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or 5. C2-C6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; (f) â€”OR2, where R2 is previously defined; (g) â€”S(O)nR11, where n=0, 1 or 2, and R11 is selected from hydrogen, R1 and R2, where R1 and R2 are as previously defined; (h) â€”OC(O)R11, where R11 is as previously defined; (i) â€”C(O)R11, where R11 is as previously defined; (j) â€”C(O)NHR11, where R11 is as previously defined; (k) â€”OC(O)NHR11, where R11 is as previously defined; (l) â€”NHC(O)R11, where R11 is as previously defined; (m) â€”NHC(O)NHR11, where R11 is as previously defined; (n) â€”NHS(O)nR11, where n and R11 are as previously defined; (o) â€”NR14R15, where R14 and R15 are each independently R11, where R11 is as previously defined; or (p) â€”NHR3, where R3 is an amino protecting group; B is selected from: (a) hydrogen; (b) deuterium; (c) â€”CN; (d) â€”NO2; (e) halogen; (f) â€”OH; (g) â€”R1, where R1 is as previously defined; (h) â€”R2, where R2 is as previously defined; or (i) â€”ORp, where Rp is as previously defined; provided that when B is halogen, â€”NO2, â€”OH or ORp, A is R1 or R2; or, alternatively, A and B taken together with the carbon atom to which they are attached are selected from: (a) C&boxH;O; (b) C(OR2)2, where R2 is as previously defined; (c) C(SR2)2, where R2 is as previously defined; (d) C(OR12)(OR13), where R12 and R13 taken together are â€”(CH2)mâ€”, and where m=2 or 3; (e) C(SR12)(SR13), where R12 and R13 taken together are â€”(CH2)mâ€” and where m is as previously defined; (f) C&boxH;CR11R14, where R11 and R14 are as previously defined; (g) C&boxH;Nâ€”Oâ€”R11, where R11 is as previously defined; (h) C&boxH;NNHR11, where R11 is as previously defined; (i) C&boxH;NNHC(O)R11, where R11 is as previously defined; (j) C&boxH;NN&boxH;CR11R14, where R11 and R14 are as previously defined; (k) C&boxH;NNHC(O)NHR11, where R11 is as previously defined; (l) C&boxH;NNHS(O)nR11, where n and R11 are as previously defined; (m) C&boxH;NNHR3, where R3 is as previously defined; or (n) C&boxH;NR11, where R11 is as previously defined; one of X and Y is hydrogen and the other is selected from: (a) hydrogen; (b) deuterium; (c) â€”OH; (d) â€”ORp, where Rp is as previously defined; or (e) â€”NR4R5, where R4 and R5 are each independently selected from: 1. hydrogen; 2. C1-C12 alkyl, optionally substituted with one or more substituents selected from halogen, cyano, aryl, substituted aryl, heteroaryl and substituted heteroaryl; or R4 and R5, taken together with the nitrogen atom to which they are attached form a 3-10 membered heteroalkyl ring containing 0-2 additional hetero atoms selected from O, S and N; or alternatively, X and Y taken together with the carbon atom to which they are attached are selected from: (a) C&boxH;O; (b) C&boxH;NR11, where R11 is as previously defined; (c) C&boxH;NC(O)R11, where R11 is as previously defined; (d) C&boxH;Nâ€”OR6, where R6 is selected from: 1. hydrogen; 2. â€”CH2O(CH2)2OCH3, 3. â€”CH2O(CH2O)nCH3, where n is as previously defined; 4. â€”C1-C12 alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, aryl, substituted aryl, heteroaryl and substituted heteroaryl; 5. C3-C12 cycloalkyl; 6. C(O)â€”C1-C12 alkyl; 7. C(O)â€”C3-C12 cycloalkyl; 8. C(O)â€”R1, where R1 is as previously defined; or 9. â€”Si(Ra)(Rb)(Rc), wherein Ra, Rb and Rc are each independently selected from C1-C12 alkyl, aryl and substituted aryl; or (e) C&boxH;Nâ€”Oâ€”C(R7)(R8)â€”Oâ€”R6, where R6 is as previously defined, provided that R6 is not C(O)â€”C1-C12 alkyl, C(O)â€”C3-C12 cycloalkyl, or C(O)â€”R1; and R7 and R8 taken together with the carbon atom to which they are attached form a C3-C12 cycloalkyl group or each is independently selected from: 1. hydrogen; or 2. C1-C12 alkyl; L is selected from: (a) â€”CH(OH)CH3; (b) C1-C6 alkyl, optionally substituted with one or more substituents selected from halogen, cyano, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; (c) C2-C6 alkenyl, optionally substituted with one or more substituents selected from halogen, cyano, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or (d) C2-C6 alkynyl, optionally substituted with one or more substituents selected from halogen, cyano, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; W is selected from: (a) C2C6 alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; (b) C2-C6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or (c) C2-C6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S and N, optionally substituted with one or more substituents selected from halogen, cyano, oxo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; Z is selected from: (a) hydrogen; (b) â€”OH; (c) â€”ORp, where Rp is as previously defined; (d) â€”OR11, where R11 is as previously defined; (e) â€”OC(O)R11, where R11 is as previously defined; (f) â€”OC(O)NHR11, where R11 is as previously defined; (g) â€”S(O)nR11, where n and R11 are as previously defined; or (h) â€” where R3â€³ is hydrogen or methyl; R4â€³ is hydrogen or Rp, where Rp is as previously defined; and R2â€² is hydrogen or Rp, where Rp is as previously defined.