Patent ID: 6410510
Filing Date: 2002-06-25
Classification: A61K,C07K

Abstract:
A method of increasing striatal GABAergic neuronal survival comprising direct administration, to the central nervous system, of an effective dose of a modified ciliary neurotrophic factor selected from the group consisting of human ciliary neurotrophic factor as set forth in SEQ. NO. 1 having the modification Gln63â†’Arg, human ciliary neurotrophic factor as set forth in SEQ. NO. 1 having the modifications Gln63â†’Arg and Trp64â†’Ala, human ciliary neurotrophic factor as set forth in SEQ. NO. 1 having the modifications Cys17â†’Ala and Gln63â†’Arg and a deletion of the terminal 13 amino acid residues, and human ciliary neurotrophic factor as set forth in SEQ. NO. 1 having the modifications Gln63â†’Arg and a deletion of the terminal 13 amino acid residues.