Patent ID: 6506755
Filing Date: 2003-01-14
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinA is a linear C1-C6-alkylene chain or a group >CHR, wherein R is a C1-C6-alkyl residue, an aryl residue, an aralkyl residue or a carboxyalkyl residue, A1 and A2 each independently in any combination are a linear or branched saturated or unsaturated C1-C6-alkylene chain, R1 and R2 each independently in any combination are a group of formula II, formula III or formula IV, wherein X is an oxygen or sulphur atom and each Y independently is a nitrogen or carbon atom, with the proviso that both Y's can not simultaneously be nitrogen, Z is a C1-C4-alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, C3-C5-alkenyl, C1-C4-alkoxy, C1-C4-alkylthio, acylamino, (alkyl)aminocarbonyl, C1-C4-alkyl-carbonyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, trifluoromethylthio, nitro, hydroxy or carboxy group or a chlorine, bromine or fluorine atom or the aromatic ring in formulae II-IV is substituted with a methylenedioxy or ethylenedioxy group and n is a whole number between 0 and 3, whereby the Z substituents can be present in any positions, with the proviso that the R1-A1- and R2-A2- residues can not simultaneously be an unsubstituted benzyl residue when A is a methylene group, or a pharmaceutically acceptable salt or ester of a compound of formula I, or a position isomer, optically active form, racemate or diastereomer mixture thereof.