Patent ID: 6316009
Filing Date: 2001-11-13
Classification: A61P,C07C

Abstract:
A biphenyl compound substituted with an aromatic radical, having the following formula (I) ##STR13##in whichAr represents an aromatic radial having the formula (a) ##STR14##R.sub.1 represents --COR.sub.9,R.sub.2 and R.sub.3, taken together, form a 5- or 6-membered ring, optionally substituted with at least one methyl,R.sub.4 represents H, a halogen atom, linear or branched C.sub.1 -C.sub.20 alkyl, --OR.sub.10, --OCOR.sub.11 or a polyether radical,R.sub.5 represents H, a halogen atom, linear or branched C.sub.1 -C.sub.20 alkyl, --OCOR.sub.11, --OR.sub.12, mono- or polyhydroxyalkyl, ##STR15##--(CH.sub.2).sub.n --NHCOCH.sub.3, --CH.dbd.CH--COR.sub.13, --(CH.sub.2.sub.n,COR.sub.13 n being 0 to 6, --O--(CH.sub.2).sub.m COR.sub.13, --O--(CH.sub.2).sub.m OH, m being 1 to 12, optionally substituted aryl, optionally substituted aralkyl, a polyether radical or a --CH.sub.2 -polyether radical,R.sub.6 represents H, lower alkyl or --OR.sub.10,R.sub.7 represents H, a halogen atom, linear or branched C.sub.1 -C.sub.20 alkyl, --OR.sub.10 or --OCOR.sub.11 or a polyether radical,R.sub.8 represents H, lower alkyl or --COR.sub.11,R.sub.9 represents --OR.sub.14R.sub.10 represents H or lower alkyl,R.sub.11 represents lower alkyl,R.sub.12 represents H, linear or branched C.sub.1 -C.sub.20 alkyl, mono- or polyhydroxyalkyl, or optionally substituted aryl or aralkyl,R.sub.13 represents H, lower alkyl, --OR.sub.10, aryl or ##STR16##R.sub.14 represents H, alkyl, linear or branched C.sub.1 -C.sub.20 alkyl, alkenyl, mono- or polyhydroxyalkyl, or optionally substituted aryl or aralkylr' and r"", which may be identical or different, represent H, OH, lower alkyl, mono- or polyhydroxyalkyl, or optionally substituted aryla salt of the compound of formula (I) when R.sub.1 represents a carboxylic acid function, or an optical or geometrical isomer of the said compound of formula (I).