Patent ID: 8731640
Filing Date: 2014-05-20
Classification: G01N,G01R,Y10T

Abstract:
1. A fluid path system comprising: a vial to contain a pharmaceutical product therein; the pharmaceutical product positioned within the vial wherein said pharmaceutical product comprises a material to enhance contrast in at least one of magnetic resonance (MR) imaging and nuclear magnetic resonance (NMR) spectroscopy; a dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel to contain a dissolution medium used to dissolve said pharmaceutical product forming a mixture; a dissolution medium positioned within the pressure vessel wherein said dissolution medium comprises a base solution and a buffering agent; a delivery fluid path having a first end hermetically attached to the vial to transport therefrom a mixture of the dissolved pharmaceutical product and the dissolution medium; wherein the dissolution fluid path and the delivery fluid path are tubular structures and the dissolution fluid path is positioned internal to or parallel to the delivery fluid path; a receiving vessel connected to a second end of the delivery fluid path to receive the mixture; a dissolution fluid path valve positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium; a delivery fluid path valve to control flow of the mixture from the delivery fluid path to the receiving vessel; a filter cartridge integrated within the delivery fluid path to remove at least one of an electron paramagnetic agent (EPA) and a processing agent from the mixture before entering the receiving vessel; and a sliding seal unit positioned between the pressure vessel and the vial to seal a cryogenically cooled chamber containing the vial therein from an ambient environment without contacting contents of the vial, and wherein said sliding seal unit bisects the dissolution fluid path and the delivery fluid path and is capable of traversing the length of said fluid paths.