Patent ID: 6331539
Filing Date: 2001-12-18
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of the formula (I): ##STR241##whereinR.sub.1 is -alkyl-NR.sub.3 --SO.sub.2 --X--R.sub.4 or -alkenyl-NR.sub.3 --SO.sub.2 --X--R.sub.4 ;X is a bond or --NR.sub.5 --;R.sub.4 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, each of which may be unsubstituted or substituted by one or more substituents selected from the group consisting of:-alkyl;-alkenyl;-aryl;-heteroaryl;-heterocyclyl;-substituted cycloalkyl;-substituted aryl;-substituted heteroaryl;-substituted heterocyclyl;--O-alkyl;--O-(alkyl).sub.0-1 -aryl;--O-(alkyl).sub.0-1 -substituted aryl;--O-(alkyl).sub.0-1 -heteroaryl;--O-(alkyl).sub.0-1 -substituted heteroaryl;--O-(alkyl).sub.0-1 -heterocyclyl;--O-(alkyl).sub.0-1 -substituted heterocyclyl;--COOH;--CO--O-alkyl;--CO-alkyl;--S(O).sub.0-2 -alkyl;--S(O).sub.0-2 -(alkyl)-aryl;--S(O).sub.0-2 -(alkyl)-substituted aryl;--S(O).sub.0-2 -(alkyl)-heteroaryl;--S(O).sub.0-2 -(alkyl)-substituted heteroaryl;--S(O).sub.0-2 -(alkyl)-heterocyclyl;--S(O).sub.0-2 -(alkyl)-substituted heterocyclyl;-(alkyl).sub.0-1 --NR.sub.3 R.sub.3 ;-(alkyl).sub.0-1 --NR.sub.3 --CO--O-alkyl;-(alkyl).sub.0-1 --NR.sub.3 --CO-alkyl;-(alkyl).sub.0-1 --NR.sub.3 --CO-aryl;-(alkyl).sub.0-1 --NR.sub.3 --CO-substituted aryl;-(alkyl).sub.0-1 --NR.sub.3 --CO-heteroaryl;-(alkyl).sub.0-1 --NR.sub.3 --CO-substituted heteroaryl;--N.sub.3 ;-halogen;-haloalkyl;-haloalkoxy;--CO-haloalkyl;--CO-haloalkoxy;--NO.sub.2 ;--CN;--OH;--SH; and in the case of alkyl, alkenyl, or heterocyclyl, oxo;R.sub.2 is selected from the group consisting of:-hydrogen;-alkyl;-alkenyl;-aryl;-substituted aryl;-heteroaryl;-substituted heteroaryl;-alkyl-O-alkyl;-alkyl-O-alkenyl; and-alkyl or alkenyl substituted by one or more substituents selected from the group consisting of:--OH;-halogen;--N(R.sub.3).sub.2 ;--CO--N(R.sub.3).sub.2 ;--CO--C.sub.1-10 alkyl;--CO--O--.sub.C1-10 alkyl;--N.sub.3 ;-aryl;-substituted aryl;-heteroaryl;-substituted heteroaryl;-heterocyclyl;-substituted heterocyclyl;--CO-aryl;--CO-(substituted aryl);--CO-heteroaryl; and--CO-(substituted heteroaryl);each R.sub.3 is independently selected from the group consisting of hydrogen and C.sub.1-0 alkyl;R.sub.5 is selected from the group consisting of hydrogen and C.sub.1-10 alkyl, or R.sub.4 and R.sub.5 can combine to form a 3 to 7 membered heterocyclic or substituted heterocyclic ring;n is 0 to 4 and each R present is independently selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 alkoxy, halogen and trifluoromethyl, or a pharmaceutically acceptable salt thereof.