Patent ID: 8946145
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K

Abstract:
1. A modified compstatin peptide (ICVVQDWGHHRCT (cyclic C2-C12); SEQ ID NO:1), in which the Gly at position 8 is N-methylated to constrain the backbone conformation of the peptide at that location, and comprising one or more additional modifications selected from: a) acetylated N-terminus; b) Ala instead of His at position 9 of the peptide; c) Trp or an analog of Trp instead of Val at position 4 of the peptide; d) halogenated Trp at position 7 of the peptide; e) Ile, Leu, Nle, N-methyl Thr or N-methyl Ile instead of Thr at position 13 of the peptide; and f) amidated C-terminus.