Patent ID: 6500854
Filing Date: 2002-12-31
Classification: A61K,A61P,C07D

Abstract:
A method for promoting chondrogenesis comprising oral or parenteral administration, to a patient in need thereof, of an effective amount of an agent comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: whereinR1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group with an optional substituent; R2 represents a hydrogen atom, a lower alkyl group with an optional substituent, a lower alkenyl group with an optional substituent, a lower alkynyl group with an optional substituent, a lower alkoxy group with an optional substituent, an acyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent; R3 represents a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent; R4 represents a hydrogen atom, a lower alkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, â€”OR5, â€”SR5 or â€”NR6NR7 wherein R5, R6 and R7 may be the same or different and each represents a hydrogen atom, a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, a lower alkoxy group or an amino group with an optional substituent, or R6 and R7 may together form a group represented by â€”(CH2)mâ€” or â€”(CH2)1NR8(CH2)kâ€” wherein k, 1 and m each represents an integer of 1-8 and R8 represents a hydrogen atom or a lower alkyl group; X and Y may be the same or different and each represents â€”CH2â€”, â€”NHâ€” or â€”Oâ€”; and n represents an integer of 0-4.