Patent ID: 6143793
Filing Date: 2000-11-07
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A surfactant-free aqueous composition for administration to a nail for the treatment of onychomycoses comprisinga) a pharmaceutically-effective amount of terbinafine hydrochloride;b) water;c) a C.sub.2 -C.sub.8 alkanol; andd) a penetration agent in an amount effective to allow penetration of terbinafine hydrochloride into and through the keratinized ungual layer of the nail, said penetration agent being selected from the group consisting of glycols, glycolmonoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, N-methyl-pyrrolidone-2, pyrrolidone-2, ethyl lactate, polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol glyceryl laurate and dimethylacetamide.