Patent ID: 8877804
Filing Date: 2014-11-04
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A method for modulating chemokine receptors, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I wherein: R R R R R R R R R R R R R R N-{2-[(3-aminobenzyl)thio]phenyl}-1-benzofuran-2-sulfonamide; N-{2-[(3-nitrobenzyl)sulfinyl]phenyl}-1-benzofuran-2-sulfonamide; N-{2-[(3-aminobenzyl)sulfinyl]phenyl}-1-benzofuran-2-sulfonamide; N-{2-[(3-nitrobenzyl)sulfonyl]phenyl}-1-benzofuran-2-sulfonamide; and N-{2-[(3-aminobenzyl)sulfonyl]phenyl}-1-benzofuran-2-sulfonamide; and with the proviso that R wherein the disease treatable by such modulation is dry eye disease.