Patent ID: 6147075
Filing Date: 2000-11-14
Classification: A61K,A61P,C07D

Abstract:
A method of treating chronic pain, treating or preventing anxiety, treating or preventing convulsions, inducing anesthesia, treating or preventing NMDA receptor-ion channel psychosis, inducing a hypnotic effect, or treating or preventing opiate tolerance, comprising:administering to an animal in need of such treatment an effective amount of a compound having the Formula: ##STR46## or a tautomer or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is alkyl, azido, alkoxy, hydroxy, haloalkyl, halo, nitro, cyano or alkanoylamino;R.sup.2 is alkyl, azido, alkoxy, aralkoxy, cyano, haloalkyl, halo, hydroxy or nitro;R.sup.3 is alkyl, azido, alkoxy, cyano, halo, haloalkyl or hydroxy;R.sup.4 is hydrogen or fluoro;provided that (a) at least one of R.sup.1, R.sup.2 or R.sup.3 is hydroxy or azido, or (b) at least one of R.sup.2 or R.sup.3 is alkyl or alkoxy, or (c) R.sup.1 is cyano.