Patent ID: 7834180
Filing Date: 2010-11-16
Classification: A61P,C07D

Abstract:
1. A method for preparing a compound having formula 1: or a pharmaceutically acceptable salt thereof, wherein: A, V, and Z are independently H, halo, azido, R W is NR X is NR each R each R R R is a substituent at any position on B′; and is H, OR B′ is an optionally substituted phenyl ring; n is 0-4; comprising: contacting a compound having formula (6A) wherein each L and L with a compound having formula (7) or tautomers thereof wherein n, X, B′ and R are as defined in formula (1); and W is OR wherein said compound having formula (6A) is contacted with said compound having formula (7) or tautomers thereof in the presence of a non-nucleophilic base to produce a compound having formula (1); and wherein each optionally substituted group is unsubstituted or is substituted with one or more halo, OR where R