Patent ID: 9044460
Filing Date: 2015-06-02
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising a trio of anti-EGFR antibodies comprising a first monoclonal antibody, a second monoclonal antibody and a third monoclonal antibody, wherein (i) the first antibody is or binds to the same epitope as, antibody ca (comprising heavy chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 29, 30 and 34, respectively, and light chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 48, 45 and 49, respectively); (ii) the second antibody is or binds to the same epitope as, antibody cd (comprising heavy chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 29, 30 and 31, respectively, and light chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 53, 54 and 55, respectively); and (iii) the third antibody is or binds to the same epitope as, antibody ch (comprising heavy chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 23, 24 and 26, respectively, and light chain CDRs 1, 2 and 3 set forth in SEQ ID NOs: 39, 40 and 42, respectively).