Patent ID: 6479460
Filing Date: 2002-11-12
Classification: A61K,A61P,C07K

Abstract:
Pseudopeptidic osteogenic growth polypeptide (OGP) analogs having the general formula whereinA, B, D and E, which may be the same or different, represent CONH, CH2NH, CH2S, CH2O, NHCO, N(CH3)CO, (CH2)2, CH&boxH;CH, C(O)CH2, CH2SO or C(O)O, M represents C(O)OH, CH2OH, C(O)NH2, C(O)OCH3, CH2OCH3, H, C(O)NHCH3, or C(O)N(CH3)2, Z represents NH2, H, NHCH3, N(CH3)2, OH, SH, OCH3, SCH3, C(O)OH, C(O)NH2, C(O)OCH3, C(O)NHCH3 or C(O)N(CH3)2, n and m each represent an integer of from 1 to 6, X and Y, if in the ortho or para positions, each represent OH, OCH3, F, Cl, Br, CF3, CN, NO2, NH2, NHCH3, N(CH3)2, SH, SCH3, CH2OH, NHC(O)CH3, C(O)OH, C(O)OCH3, C(O)NH2, C(O)NHCH3, C(O)N(CH3)2, or CH3, and Y, if in the meta position, represents C(O)C6H5, C(O)CH3, C6H5, and, if in the ortho or para positions can additionally represent C(O)C6H5, C(O)CH3, C6H5, CH2 C6H5, CH2CH3, CH(CH3)2, or C6H11 with the proviso that said compound is not Tyr-Gly-Phe-Gly-Gy (SEQ ID NO 61).