Patent ID: 8124783
Filing Date: 2012-02-28
Classification: C07D

Abstract:
1. A process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine of formula (1) or its salt thereof employing a novel intermediate, the process comprising: (a) oxidizing 4-[(5,6-dimethoxy-1-indanon-2-ylidene)methyl]pyridine of formula (4) using oxidizing agent in presence of solvent to get 4-[(5,6-dimethoxy-1-indanon-2-ylidene)methyl]pyridine N-oxide of formula (3) a novel intermediate, (b) reducing 4-[(5,6-dimethoxy-1-indanon-2-ylidene)methyl]pyridine N-oxide of formula (3) in presence of hydrogenating catalyst in solvent to yield 4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine of formula (2) or its salt thereof, (c) treating 4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine of formula (2) or its salt thereof with benzylating agent in presence of base and solvent, optionally in presence of phase transfer catalyst to produce 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine of formula (1) or its salt thereof.