Patent ID: 6455545
Filing Date: 2002-09-24
Classification: A61P,C07D

Abstract:
A compound of the general formula (I) wherein:R1 is selected from hydrogen, a branched or straight C1-C6 alkyl, C1-C6 alkenyl, C3-C8 cycloalkyl, C4-C8(alkyl-cycloalkyl) wherein alkyl is C1-C2 alkyl and cycloalkyl is C3-C6 cycloalkyl; C6-C10 aryl; or heteroaryl having from 5 to 10 atoms selected from any of C, S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, â€”(CH2)pCF3, halogen, â€”CONR5R4, â€”COOR5, â€”COR5, â€”(CH2)pNR5R4, â€”(CH2)pCH3(CH2)pSOR5R4, â€”(CH2)pSO2R5, and â€”(CH2)pSO2NR5, wherein R4 and R5 are each and independently as defined for R1 above and p is 0, 1 or 2; (C1-C2 alkyl)-(C6-C10 aryl); or (C1-C2 alkyl)heteroaryl, the heteroaryl moieties having from 5 to 10 atoms selected from any of C, S, N and O, and where the aryl or heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, â€”(CH2)qCF3, halogen, â€”CONR5R4, â€”COOR5, â€”COR5, â€”(CH2)qNR5R4, â€”(CH2)qCH3(CH2)qSOR5R4, â€”(CH2)qSO2R5, â€”(CH2)qSO2NR5 and â€”(CH2)pOR5, wherein R4 and R5 are each and independently as defined for R1 above and q is 0, 1 or 2; and wherein R18, R19, R20, R21, R22, R23, R24 and R25 is each and independently hydrogen, C1-C6 alkyl or C1-C6 alkenyl; R2 and R3 are each and independently hydrogen or C1-C6 alkyl; A is selected from wherein R8, R9, R10, R11, R12, R13, R14, R15, R16 and R17 are each and independently as defined for R1 above, and wherein the phenyl ring of each A substituent may be optionally and independently substituted at any position of the phenyl ring by 1 or 2 substituents Z1 and Z2 which are each and independently selected from hydrogen, CH3, â€”(CH2)qCF3, halogen, CONR6R7, â€”COOR6, â€”COR6, â€”(CH2)rNR6R7, â€”(CH2)rCH3(CH2)rSOR6, â€”(CH2)rSO2R6 and â€”(CH2)rSO2NR6R7 wherein R6 and R7 are each and independently as defined for R1 above and r is 0, 1, or 2; Q is C5-C6 hydroaryl or heterohydroaromatic having 5 or 6 atoms selected from any one of C, S, N and O; C5-C6 cykloalkyl, or heterocycloalkyl having 5 or 6 atoms selected from any one of C, N, O and S; and where each Q may optionally be substituted by a substituent Z1 and Z2 as defined above; B is a substituted or unsubstituted aromatic, heteroaromatic, hydroaromatic or heterohydroaromatic moiety having from 5 to 10 atoms selected from any of C, S, N and O, optionally and independently substituted by 1 or 2 substituents independently selected from hydrogen, CH3, â€”(CH2)tCF3, halogen, â€”(CH2)tCONR5R4, â€”(CH2)tNR5R4, â€”(CH2)tCOR5, â€”(CH2)tCOOR5, â€”OR5, â€”(CH2)tSOR5, â€”(CH2)tSO2R5, and â€”(CH2)tSO2NR5R4, wherein R4and R5 are each and independently as defined for R1 above, and t is 0, 1, 2 or 3; R4 and R5 are each and independently as defined for R1 above; or a pharmaceutically acceptable salt, isomer, hydrate, isoform or prodrug thereof.