Patent ID: 6066651
Filing Date: 2000-05-23
Classification: C07D

Abstract:
A compound represented by the general formula (I): ##STR9## wherein M is (CH.sub.2).sub.m, CH.dbd.CH or C.tbd.C; A is selected from any of piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, NHR.sub.2 or ##STR10## wherein R.sub.9 is selected from any of H, alkyl, CH(NH), CMe(NH) or acyl;R.sub.10 is H or C(O)N(R.sup.1)YZ,wherein R.sup.1 is selected from H or cycloalkyl;R.sub.2 is selected from any of H, alkyl or acyl;R.sub.5 is H or C(O)NHQ(CHW).sub.r CO.sub.2 R.sub.8 ; wherein Q is selected from CH.sub.2, CH-aryl, CH-heteroaryl, CH-substituted-heteroaryl or CH-alkyl; W is selected from H or N(R.sub.6)T-R.sub.7 ; wherein R.sub.6 is selected from any of H, alkyl or acyl; T is selected from C(O), C(N-CN) or SO.sub.2 ; R.sub.7 is selected from any of alkyl, aryl, aralkyl, alkoxy, or aminoalkyl; and R.sub.8 is CH.sub.2 C(O)NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 are selected from H, alkyl, or cycloalkyl;m is the integer 1, 2, or 3;X is selected from any of C(O), C(O)O, C(O)NH, CH.sub.2, or SO.sub.2 ;n is the integer 1, 2, or 3;r is 0 or 1;Y is selected from any of (CH.sub.2).sub.p, CH(R.sup.3) (CH.sub.2).sub.q, (CH.sub.2).sub.q CH(R.sup.3), (CH(CO.sub.2 R.sup.4)CH.sub.2).sub.q, (CH.sub.2).sub.q CHOH or piperidine-3-carboxylic acid; with the proviso that when Y is (CH.sub.2).sub.p and p is 2, X is other than C(O) or when X is C(O) then either R.sup.1 is other than H or R.sub.2 is other than H, and with the proviso that when Y is (CH(CO.sub.2 R.sup.4)CH.sub.2).sub.q X is other than C(O) or CH.sub.2 ;p is 2 or 3;q is 1, 2, or 3;R.sup.3 is alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, aryl, aralkyl or heteroaryl;R.sup.4 is H or alkyl or cycloalkyl;Z is Ct.sub.2 CHC(O)NR.sub.11 R.sub.12 ; provided that at least one of R.sub.5 and R.sub.10 is hydrogen and R.sub.5 and R.sub.10 are not hydrogen at the same time;or the enantiomer or the pharmaceutically acceptable salt thereof.