Patent ID: 6320060
Filing Date: 2001-11-20
Classification: C07D

Abstract:
A process for producing a compound of the formula (I): ##STR31##wherein R is hydrogen or a hydroxy-protecting group, or a reactive derivative thereof, which comprises introducing a propargyl group into 4-mercaptophenol, and protecting the hydroxyl group of the 4-mercaptophenol, to yield a compound of the formula (II): ##STR32##wherein R.sup.1 is a hydroxy-protecting group, oxidizing the compound (II) to yield a compound of the formula (III): ##STR33##wherein R.sup.1 is a hydroxy-protecting group; subjecting the compound (III) to a thermal rearrangement reaction to yield a compound of the formula (IV): ##STR34##wherein R.sup.1 is as defined above; and subjecting the compound (IV) to stepwise oxidation of the hydroxymethyl group and optionally deprotection.