Patent ID: 6794532
Filing Date: 2004-09-21
Classification: C07B,C07C,C07D

Abstract:
A process for enantioselectively hydrogenating a prochiral ketone to an (S)-alcohol, which comprises hydrogenating the prochiral ketone in the presence of a platinum catalyst, a modifier and hydrogen, wherein the modifier is a compound of the formula XI with 8(R),9(S)-configuration whereR9 is H or CH3â€”CH&boxH; and R7 is H or methyl, and R8 is C6-C14-aryl which is unsubstituted or substituted by C1-C4-alkyl or C1-C4-alkoxy, or R8 is C5-C13-heteroaryl having a heteroatom selected from the group consisting of â€”N&boxH;, â€”Oâ€”, â€”Sâ€” and â€”N(C1-C4-alkyl)- which heteroaryl is unsubstituted or substituted by hydroxy, C1-C4-alkyl or C1-C4-alkoxy.