Patent ID: 6537764
Filing Date: 2003-03-25
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
A method of identifying an inhibitor of a human Câ€”C chemokine receptor 3 comprising:a) combining a compound to be tested, a host cell expressing a recombinant protein comprising a Câ€”C chemokine receptor 3 polypeptide, and a ligand of said receptor under conditions suitable for binding of ligand to said polypeptide, wherein said polypeptide has at least 90% amino acid sequence identity with SEQ ID NO:2 or SEQ ID NO:6 and binds RANTES; and b) detecting or measuring the formation of a complex between said polypeptide and said ligand, wherein inhibition of complex formation by the compound is indicative that the compound is an inhibitor.