Patent ID: 8932636
Filing Date: 2015-01-13
Classification: A61B,A61K,A61N,B82Y,G01R

Abstract:
1. A method of treating a tumor at a discrete and/or metastasized site of a lesion by targeted thermotherapy, the method comprising the steps of (a) administering ferromagnetic nanoparticles or nanowires and positioning an electromagnet at the lesion site, (b) allowing elapse of a time interval sufficient to attract, concentrate, and expose a sufficient amount of nanoparticles or nanowires to a reversible electromagnet at the lesion site, (c) thereafter exposing the nanoparticles or nanowires to the reversible electromagnet or an alternating magnet to achieve a rapidly alternating magnetic field in the ferromagnetic nanoparticles or nanowires sufficient to heat the ferromagnetic nanoparticles or nanowires to a desired temperature to generate an acoustic signal producing conditions at the target site sufficient to heat the nanoparticles or nanowires sound in-situ to hyperthermally treat cells to effect thermotherapy at the lesion site, (d) recording and maintaining the desired temperature for a desired period sufficient to effect thermotherapy controlled by a photoacoustic imaging system communicated by a processor with a source of energy or the electromagnet, and (e) thereafter removing the magnet or electromagnet, the method resulting in a predetermined and controlled define targeted thermotherapy and imaging.