Patent ID: 6329356
Filing Date: 2001-12-11
Classification: A61K,A61P

Abstract:
A method for modulating amyloid deposition in a subject, comprising administering to a subject an effective amount of a therapeutic compound such that modulation of amyloid deposition occurs, wherein the therapeutic compound has the formula: ##STR12##in whichR.sup.1 and R.sup.2 are each independently hydrogen, a substituted or unsubstituted aliphatic group, an aryl group, a heterocyclic group, or a salt-forming cation;R.sup.3 is hydrogen, lower alkyl, aryl, or a salt-forming cation;R.sup.4 is hydrogen, lower alkyl, aryl or amino;X is, independently for each occurrence, O or S;Y.sup.1 and Y.sup.2 are each independently hydrogen, halogen, alkyl, amino, hydroxy, alkoxy, or aryloxy;Z is XR.sup.2 or R.sup.4 ; andn is an integer from 0 to 12.