Patent ID: 8470872
Filing Date: 2013-06-25
Classification: A61P,C07D

Abstract:
1. A method of reducing inflammation, treating neuropathic pain, treating allergic conjunctivitis, treating dry eye, hormonal replacement therapy, lowering cholesterol, triglycerides, or LDL levels, treating impaired cognition or providing neuroprotection, preventing conception, treating colorectal cancer, prostate cancer, breast cancer, ovarian cancer, endometrial cancer, or uterine cancer or treating a disorder in a subject comprising: identifying a subject in need thereof; and administering to the subject a pharmaceutically effective amount of one or more estrogen receptor β (ERβ) agonist; wherein the disorder is selected from the group consisting of inflammatory bowel syndrome; Crohn's disease; ulcerative proctitis or colitis; prostatic hypertrophy; uterine leiomyomnas; breast carcinoma; endometrial carcinoma; polycystic ovary syndrome; endometrial polyps; benign breast disease; adenomyosis; ovarian carcinoma; melanoma; prostate carcinoma; colon carcinoma; brain tumors; prostatitis; interstitial cystitis; bone density loss; discholesterolemia; dislipidemia; cardiovascular disease; atherosclerosis; hypertension; peripheral vascular disease; restenosis; vasospasm; neurodegenerative disorders cognitive decline; stroke; anxiety; vaginal atrophy; vulvar atrophy; atrophic vaginitis; vaginal dryness; pruritus; dyspareunia; frequent urination; urinary incontinence; urinary tract infections; vasomotor symptoms; arthritis; psoriasis; dermatitis; asthma; pleurisy; multiple sclerosis; systemic lupus erthematosis; uveitis; sepsis; hemmorhagic shock; type II diabetes; acute or chronic inflammation; acute or chronic pain; lung disorders; ophthalmologic disorders; and free radical induced disease states; and wherein the ERβ agonist is a compound of Formula I: or a pharmaceutically acceptable salt or metabolite thereof, wherein: X is selected from the group consisting of oxygen, sulfur, S═O, and SO n is an integer selected from the group consisting of 1, 2, 3 and 4; R R or two of R R or two of R R or two geminal R or two geminal R or two geminal R or two R or one of R or one of R or one of R Z is oxygen or sulfur; and R or R or R