Patent ID: 6906171
Filing Date: 2005-06-14
Classification: C07C,C07K

Abstract:
1. A process the for the preparation of a compound comprising at least two disulphide bonds from a precursor having at least two pairs of thiol groups, each pair of thiol groups being protected with different thiol-protecting groups selected from acetamidomethyl (Acm), 4-methylbenzyl (MBzl) and t-butyl (tBu), said process comprising: (i) reaction of the precursor with an acid in the presence of an oxidising agent at a first temperature sufficient to effect deprotection of tBu protected thiols and disulphide bond formation for a first pair of protected thiol groups; (ii) raising the temperature of the reaction mixture from step (i) to a second temperature sufficient to effect deprotection of Acm and/or MBzl protected thiols and disulphide bond formation for a second pair of protected thiol groups.