Patent ID: 8962279
Filing Date: 2015-02-24
Classification: C12Q,G01N

Abstract:
1. A device comprising: a substrate comprising a plurality of individually-addressable electronic sensors wherein each electronic sensor has a surface and the sensor surface comprises attached molecules capable of selectively binding pyrophosphate ions, attachment sites for nucleic acid molecules to be sequenced wherein one attachment site is located in close proximity to one sensor, wherein in close proximity is between 0 nm to 100 nm of the sensor surface, an electronics system operably coupling a computer to the plurality of electronic sensors, and the computer capable of receiving, storing, and processing data from the electronics system and capable of assembling the sequence of a nucleic acid molecule to be sequenced wherein assembling the sequence of a nucleic acid molecule includes using data from an individually-addressable electronic sensor indicative of whether or not pyrophosphate ion is bound to the molecules capable of selectively binding pyrophosphate ions on the sensor surface.