Patent ID: 6548298
Filing Date: 2003-04-15
Classification: A01K,A61L,A61M,C12N,C12Q,C12Y

Abstract:
A method for inhibiting telomerase activity in human cells, comprising contacting the human cells in vivo with an exogenous oligonucleotide in an amount sufficient to inhibit telomerase activity, the oligonucleotide comprising at least 10 consecutive nucleotides exactly complementary to a human telomerase RNA component sequence,wherein the human telomerase RNA component comprises a sequence located in an Ëœ2.5 kb HindIII-SacI insert of plasmid pGRN33 (ATCC 75926), wherein the oligonucleotide does not consist of a plurality of 5â€²-TTAGGG-3â€² telomeric repeat units, and wherein the oligonucleotide inhibits telomerase activity.