Patent ID: 8835387
Filing Date: 2014-09-16
Classification: A61K,A61P,C12N,C12Q,C12Y,G01N,Y02A

Abstract:
1. A therapeutic composition, comprising a histidyl-tRNA synthetase (HRS) polypeptide of 500-506 amino acids in length that is least 90% identical to SEQ ID NO:70 (HRS(1-506)) and lacks residues 507-509 of SEQ ID NO:1, wherein the composition is: a) at least about 95% pure; b) less than about 5% aggregated; and c) substantially endotoxin-free, and wherein the HRS polypeptide has reduced interchain disulfide formation under reducing conditions relative to the polypeptide of SEQ ID NO:1 (full-length HRS).