Patent ID: 8577106
Filing Date: 2013-11-05
Classification: A61B,G06T,G16H

Abstract:
1. A method for ready automated screening, diagnosis and classification of Alzheimer's disease using magnetic resonance imaging (MRI) signal from ventricular zone contour of brain, wherein to get a topological index of the cognitive dementic brain the method comprises of the following steps: i) obtaining a gray scale MRI image of a brain slice, ii) applying a contour edge-detecting algorithm to the image to produce a binary image of the contour of the ventricular zone, iii) employing a grid covering method to calculate the first order topological metric index of the contour of ventricular zone, iv) superimposing the binary contour image on a succession of square grids of increasing edge length wherein a metric grid square is counted only once if the square is encountered by a border of the binary contour image; and v) plotting the log of the number of grid squares encountered against the log of the edge length of the grid area, wherein the gradient of the plot is the linear topological metric index.