Patent ID: 8580838
Filing Date: 2013-11-12
Classification: A61P,C07D

Abstract:
1. A method of treating or ameliorating cardiac reperfusion injury, comprising administering to a subject in need thereof a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: R R G is phenyl substituted with R B is phenyl; C is a pyrazole or imidazole; D is C(O)NH(cyclopropyl); R (a) amino, alkylamino or dialkylamino; (b) acylamino; (c) optionally substituted phenyl or naphthyl; (d) heteroalkylcarbonyl; (e) —Y-(alkylene)-R (f) —CONR (g) —S(O) (h) cycloalkylalkyl, cycloalkylalkenyl and cycloalkylalkynyl, all optionally substituted with alkyl, halo, hydroxy or amino; (i) Z-alkylene-NR (j) —OC(O)-alkylene-CO (k) hydrogen; (l) halo; (m) cyano; (n) hydroxy; (o) optionally substituted alkoxy; (p) C(L)R (q) optionally substituted alkyl; R (a) hydrogen; (b) halo; (c) alkyl; (d) alkoxy; and (e) hydroxy; R (a) hydrogen; (b) halo; and (c) alkyl; R (a) hydrogen; (b) halo; (c) alkyl; and (d) alkoxy.