Patent ID: 6974831
Filing Date: 2005-12-13
Classification: A61P,C07D

Abstract:
1. A cycloalkylfused indole compound of formula (I) , or a pharmaceutically acceptable salt, solvate or prodrug thereof; wherein; n is 1, 2 or 3; R R R and Z is selected from an oxime amide or oxime thioamide group represented by the formulae, wherein X is oxygen or sulfur, R a is independently selected from hydrogen, C 1 -C 8 alkyl, aryl, C 1 -C 8 alkaryl, C 1 -C 8 alkoxy, aralkyl and —CN; R or the group -(L wherein R 4a is selected from the group consisting of OH, (C 1 -C 6 )alkoxy, and aryloxy; and wherein R 4b is hydrogen or an organic substituent selected from the group consisting of (C 1 -C 8 )alkyl, aryl, (C 7 -C 14 )aralkyl, (C 7 -C 14 )alkaryl, (C 3 -C 8 )cycloalkyl, (C 1 -C 8 )alkoxyalkyl and these groups substituted with halogen, —CF 3 , —OH, (C 1 -C 8 )alkyl, amino, carbonyl, and —CN; or R wherein R 4c is selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, heteroaryl and aryl, —CF 3 ; and wherein NR 4d is an amino acid residue of either a natural or unnatural amino acid with the nitrogen atom being part of the amino group of the amino acid, R R