Patent ID: 7795007
Filing Date: 2010-09-14
Classification: B01J,B82Y,C40B,G01N

Abstract:
1. A device for differentiating between a post-translationally modified peptide and a peptide, comprising: (a) a support having a top surface; (b) metal overlying the top surface of the support providing a metallized surface; (c) a functionalized thiol compound comprising the reaction product of a first thiol compound comprising a —S-Metal linkage formed when a thiol compound comprising an —SH group is attached to the top of the metallized surface and further comprising an amine or ammonium group or an ammonium salt thereof linked to a heterobifunctional linker comprising a functional group that is capable of reacting with an —SH group on a post-translationally modified peptide or a peptide; and (d) a liquid crystal in contact with the functionalized thiol compound of (c) above, wherein the post-translationally modified peptide, and the peptide are bound to the functionalized thiol compound of (c) and wherein the orientation of the liquid crystal in contact with the post-translationally modified peptide is different than the orientation of the liquid crystal in contact with the peptide, thereby differentiating between the post-translationally modified peptide and the peptide.