Patent ID: 6290952
Filing Date: 2001-09-18
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
A method of dephosphorylating an endotoxin comprising:administering to a mammal a composition comprising a first alkaline phosphatase having dephosphorylating activity in vivo in an amount sufficient to dephosphorylate endotoxin produced by bacteria in vivo,optionally, a vehicle comprising a second alkaline phosphatase which may be identical to said first alkaline phosphatase, having dephosphorylating activity in vivo, wherein said second alkaline phosphatase is obtained from an isolated, purified recombinant DNA sequence encoding an alkaline phosphatase isozyme having dephosphorylating activity in vivo and;a pharmaceutically acceptable carrier, thereby dephosphorylating the endotoxin.