Patent ID: 7271176
Filing Date: 2007-09-18
Classification: A61P,C07D

Abstract:
1. A compound having the formula: or physiologically acceptable salt thereof, wherein: n is one to four; M is >CR R R R R R R Z is X R Rings A and B are independently unsubstituted or substituted; said acyl group is an aliphatic carbonyl aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl; said aliphatic group is a C said aromatic group is selected from the group consisting of phenyl, 1-naphthyl, 2-naphthyl, 1-anthracyl, 2-anthracyl, N-imidazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 2-thienyl, 3-thienyl, 2-furanyl, 3-furanyl, 2-pyrrolyl, 3-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 3-pyridazinyl, 4-pyridazinyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-pyrazinyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 5-tetrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, tetrahydronaphthyl, 2-benzothienyl, 3-benzothienyl, 2-benzofuranyl, 3-benzofuranyl, 2-indolyl, 3-indolyl, 2-quinolinyl, 3-quinolinyl, 2-benzothiazolyl, 2-benzooxazolyl, 2-benzimidazolyl, 1-isoquinolinyl, 3-quinolinyl, 1-isoindolyl, 3-isoindolyl, acridinyl, 3-benzisoxazolyl, benzocyclopentyl, and benzocyclohexyl; said non-aromatic heterocyclic group is a five to eight-membered non-aromatic ring which contains one or more heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur; said substituted aliphatic group is substituted with one or more substituents selected form the group consisting of oxo group, epoxy group, non-aromatic heterocyclic ring, benzyl group, substituted benzyl group, aromatic group, substituted aromatic group, electron withdrawing group, halo, azido, —CN, —CONR said substituted non-aromatic heterocyclic ring is substituted with one or more substituents selected from the group consisting of ═O, ═S, electron withdrawing group, halo, azido, —CN, —CONR said substituted aromatic group, substituted benzyl group, Ring A when substituted and Ring B when substituted, are substituted with one or more substituents selected from the group consisting of electron withdrawing group, aliphatic group, substituted aliphatic group, aromatic group, substituted aromatic group, halo, azido, —CN, —CONR Q is —O—, —S—, —S(O)—, —S(O) R R R R t is zero to three; u is zero or one; and p is one to five.