Patent ID: 6334996
Filing Date: 2002-01-01
Classification: A61K,C07K

Abstract:
A purified compound that predominately forms a single stereoisomer upon coordination to a metal center, the compound having the following formula I: wherein R1 is a linear or branched, saturated or unsaturated C1-4alkyl chain that is optionally interrupted by one or two heteroatoms selected from N, O and S; and is optionally substituted by one or more substituents selected from halogen, hydroxyl, amino, carboxyl, C1-4alkyl, aryl and C(O)R10; R2 is H or a substituent defined by R1; R1 and R2 may together form a 5- to 8-membered saturated or unsaturated heterocyclic ring optionally substituted by one or more substituents selected from halogen, hydroxyl, amino, carboxyl, oxo, C1-4alkyl, aryl and C(O)R10; R3, R4 and R5 are selected independently from H; carboxyl; C1-4alkyl; C1-4alkyl substituted with a substituent selected from hydroxyl, amino, sulfhydryl, halogen, carboxyl, C1-4alkoxycarbonyl and aminocarbonyl; an alpha carbon side chain of a D- or L-amino acid other than proline; and C(O)R10; R6 is an optionally substituted 3- to 6-membered heterocylic or carbocyclic ring; or R6 is wherein R11, R12 and R13 are independently selected from H, linear or branched, saturated or unsaturated C1-6alkyl chain that is optionally interrupted by one or two heteroatoms selected from N, O and S; and is optionally substituted by one or more substituents selected from the group consisting of alkoxycarbonyl, aminocarbonyl, alkoxy, an optionally substituted 3- to 6-membered heterocylic and carbocyclic ring; with the proviso that at least one of R11, R12 and R13 is not H; or R6 is wherein R14 and R15 are independently selected from H, linear or branched, saturated or unsaturated C1-6alkyl chain that is optionally interrupted by one or two heteroatoms selected from N, O and S; and is optionally substituted by one or more substituents selected from the group consisting of alkoxycarbonyl, aminocarbonyl, alkoxy, an optionally substituted 3- to 6-membered heterocylic and carbocyclic ring; with the proviso that at least one of R14 and R15 is not H; or R6 is wherein X is selected from O or S and R16 is selected from linear or branched, saturated or unsaturated C1-6alkyl chain that is optionally interrupted by one or two heteroatoms selected from N, O and S; and is optionally substituted by one or more substituents selected from the group consisting of alkoxycarbonyl, aminocarbonyl, alkoxy, and an optionally substituted 3- to 6-membered heterocylic and carbocyclic ring; R7 and R8 are selected independently from H; carboxyl; amino; C1-4alkyl; C1-4alkyl substituted by a substituent selected from hydroxyl, carboxyl and amino; and C(O)R10; R9 is selected from H and a sulfur protecting group; and R10 is selected from hydroxyl, alkoxy, an amino acid residue, a linking group and a targeting molecule.