Patent ID: 8519124
Filing Date: 2013-08-27
Classification: A61P,C07D

Abstract:
1. A compound represented by formula (I): wherein A B E represents a spacer having a main chain of 1 to 10 atom(s); L represents a bond or a spacer having a main chain of 1 to 4 atom(s); J represents (1) an aliphatic hydrocarbon group which is substituted with a group having a basic group, and also may have a substituent(s), (2) a monocyclic or condensed cyclic group which is substituted with a group having a basic group, and also may have a substituent(s), (3) a spiro-bound cyclic group which may be substituted with a group having a basic group, and also may have a substituent(s), or (4) a bridged cyclic group which may be substituted with a group having a basic group, and also may have a substituent(s); G represents a bond, a carbon atom which may have a substituent(s), an oxygen atom, a nitrogen atom which may have a substituent(s), an optionally oxidized sulfur atom, or -carbon atom which may have a substituent(s)-nitrogen atom which may have a substituent(s)-; wherein when J represents (1) or (2), G represents a bond, a carbonyl group, an oxygen atom, a nitrogen atom which may have a substituent(s) or an optionally oxidized sulfur atom, or B wherein the compound of formula (I) is chosen from (1) 4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)-2,6-dimethylbenzamide, (2) 3-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (3) 4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (4) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[(4-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (5) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(4-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}methyl)benzamide, (6) 4-{[8-(3-hydroxypropyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (7) 4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)-3-methoxybenzamide, (8) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(8-{[3-(methoxymethyl)-2-thienyl]methyl}-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzamide, (9) 4-({8-[(3-chloro-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (10) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(2-methylbenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (11) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(3-methylbenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (12) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(4-methylbenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (13) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(2-methoxybenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (14) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(3-methoxybenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (15) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(4-methoxybenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (16) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[2-(trifluoromethyl)benzyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (17) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[3-(trifluoromethyl)benzyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (18) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[4-(trifluoromethyl)benzyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (19) 2,6-dichloro-N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (20) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(8-{[3-(trifluoromethyl)-2-thienyl]methyl}-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzamide, (21) 4-[(8-{[3-(hydroxymethyl)-2-thienyl]methyl}-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (22) 2-{[2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]carbonyl}benzyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-3-thiophenecarboxylic acid, (23) 2-{[2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]carbonyl}benzyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-3-thiophenecarboxamide, (24) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[(3-methoxy-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (25) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(2-nitrobenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (26) 4-{[8-(2-cyanobenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (27) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[2-(trifluoromethoxy)benzyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (28) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[2-(methylthio)benzyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (29) 4-{[8-(2-hydroxybenzyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (30) 4-({8-[(3-fluoro-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (31) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[(5-nitro-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (32) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(2-thienylmethyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}benzamide, (33) N-(1H-imidazol-2-ylmethyl)-N-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzyl]-1H-imidazole-2-carboxamide, (34) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-8-yl}methyl)benzamide, (35) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[2-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}benzamide, (36) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-9-yl}methyl)benzamide, (37) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}benzamide, (38) N,N-bis(1H-imidazol-2-ylmethyl)-4-({9-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}methyl)benzamide, (39) N,N-bis(1H-imidazol-2-ylmethyl)-4-({4-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-9-yl}methyl)benzamide, (40) 4-[(8-{[3-(1-hydroxyethyl)-2-thienyl]methyl}-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (41) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[(3-methyl-2-thienyl)carbonyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (42) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzamide, (43) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(2-thienylmethyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]methyl}benzamide, (44) N,N-bis(1H-imidazol-2-ylmethyl)-4-({9-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-4-yl}methyl)benzamide, (45) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[2-(2-thienylmethyl)-2,7-diazaspiro[3.5]non-7-yl]methyl}benzamide, (46) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}methyl)benzamide, (47) N,N-bis(1H-imidazol-2-ylmethyl)-4-({7-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[4.4]non-2-yl}methyl)benzamide, (48) N,N-bis(1H-imidazol-2-ylmethyl)-4-({9-[(3-methyl-2-thienyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methyl)benzamide, (49) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[7-(2-thienylmethyl)-2,7-diazaspiro[3.5]non-2-yl]methyl}benzamide, (50) N,N-bis(1H-imidazol-2-ylmethyl)-4-({7-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-2-yl}methyl)benzamide, (51) 4-{[8-(2-hydroxy-2-methylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (52) 4-{[8-(3-hydroxy-3-methylbutyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (53) 4-{[8-(4-hydroxy-4-methylpentyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (54) 4-{[8-(2-ethyl-2-hydroxybutyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (55) 4-({8-[(1-hydroxycyclohexyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (56) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[8-(1-propylbutyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}benzamide, (57) 4-({8-[2-hydroxy-1-(hydroxymethyl)ethyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (58) 4-{[8-(2-hydroxy-2-propylpentyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (59) N,N-bis(1H-imidazol-2-ylmethyl)-4-({8-[2-methoxy-1-(methoxymethyl)ethyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzamide, (60) 4-{[9-(2-ethylbutyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (61) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)methyl]benzamide, (62) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(tetrahydro-2H-pyran-4-yl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}benzamide, (63) 4-[(9-cyclobutyl-3,9-diazaspiro[5.5]undec-3-yl)methyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (64) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(9-isobutyl-2,9-diazaspiro[5.5]undec-2-yl)methyl]benzamide, (65) 4-{[9-(cyclobutylmethyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (66) 4-({9-[(3-chloro-2-thienyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (67) 3-[2-(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)ethyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (68) 4-[(9-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)methyl]-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (69) 4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (70) 4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)methyl]-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (71) N-(1H-imidazol-2-ylmethyl)-4-[(9-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)methyl]-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (72) N-(1H-imidazol-2-ylmethyl)-4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (73) N-(1H-imidazol-2-ylmethyl)-4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)methyl]-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (74) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(7-isobutyl-2,7-diazaspiro[3.5]non-2-yl)methyl]benzamide, (75) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(2-isobutyl-2,7-diazaspiro[3.5]non-7-yl)methyl]benzamide, (76) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(2-isobutyl-2,8-diazaspiro[4.5]dec-8-yl)methyl]benzamide, (77) 4-{[2-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (78) 4-{[2-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (79) 4-{[9-(1-ethylpropyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (80) 4-{[9-(2,2-dimethylpropyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (81) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(4-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-9-yl)methyl]benzamide, (82) 4-{[4-(1-ethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-9-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (83) 4-{[2-(2,2-dimethylpropyl)-2,7-diazaspiro[3.5]non-7-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (84) 4-{[2-(1-ethylpropyl)-2,7-diazaspiro[3.5]non-7-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (85) 4-{[7-(2,2-dimethylpropyl)-2,7-diazaspiro[3.5]non-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (86) 4-{[7-(1-ethylpropyl)-2,7-diazaspiro[3.5]non-2-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (87) N,N-bis(1H-imidazol-2-ylmethyl)-4-[(2-isobutyl-2,9-diazaspiro[5.5]undec-9-yl)methyl]benzamide, (88) 4-{[2-(2,2-dimethylpropyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (89) 4-{[2-(1-ethylpropyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (90) 4-{[9-(2,2-dimethylpropyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (91) 4-[2-(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)ethyl]-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (92) 4-({8-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)-N,N-bis(1H-imidazol-2-ylmethyl)benzamide, (93) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-8-yl}methyl)benzenesulfonamide, (94) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[2-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}benzenesulfonamide, (95) N,N-bis(1H-imidazol-2-ylmethyl)-4-({2-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-9-yl}methyl)benzenesulfonamide, (96) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}benzenesulfonamide, (97) N,N-bis(1H-imidazol-2-ylmethyl)-4-({9-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}methyl)benzenesulfonamide, (98) N,N-bis(1H-imidazol-2-ylmethyl)-4-({4-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-9-yl}methyl)benzenesulfonamide, (99) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[9-(2-thienylmethyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}benzenesulfonamide (100) N,N-bis(1H-imidazol-2-ylmethyl)-4-({9-[(3-methyl-2-thienyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methyl)benzenesulfonamide, (101) N,N-bis(1H-imidazol-2-ylmethyl)-4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzenesulfonamide, (102) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzyl]methanamine, (103) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[3.5]non-2-yl]methyl}benzyl)methanamine, (104) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({7-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-2-yl}methyl)benzyl]methanamine, (105) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[2-(2-thienylmethyl)-2,7-diazaspiro[3.5]non-7-yl]methyl}benzyl)methanamine, (106) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}methyl)benzyl]methanamine, (107) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-8-yl}methyl)benzyl]methanamine, (108) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[2-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}benzyl)methanamine, (109) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-9-yl}methyl)benzyl]methanamine, (110) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}benzyl)methanamine, (111) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}methyl)benzyl]methanamine, (112) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({4-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-9-yl}methyl)benzyl]methanamine, (113) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-thienylmethyl)-3,9-diazaspiro[5.5]undec-3-yl]methyl}benzyl)methanamine, (114) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methyl)benzyl]methanamine, (115) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-thienylmethyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]methyl}benzyl)methanamine, (116) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-4-yl}methyl)benzyl]methanamine, (117) 1-{4-[(1′-cyclohexylspiro[indole-3,4′-piperidin]-1(2H)-yl)methyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (118) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(8-phenyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}methanamine, (119) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[2-(2-thienylmethyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}benzyl)methanamine, (120) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]phenyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (121) methyl 5-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}-2-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)benzoate, (122) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]phenyl}-N-[(1-ethyl-1H-imidazol-2-yl)methyl]-N-(1H-imidazol-2-ylmethyl)methanamine, (123) 1-[4-({8-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)phenyl]-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (124) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]phenyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-isopropyl-1H-imidazol-2-yl)methyl]methanamine, (125) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]phenyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]methanamine, (126) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]phenyl}-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (127) 1-{3-[2-(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)ethyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (128) 2-(2-{[{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}(1H-imidazol-2-ylmethyl)amino]methyl}-1H-imidazol-1-yl)ethanol, (129) [2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-cyclohexyl-2,8-diazaspiro[4.5]dec-3-yl]methanol, (130) 1-{4-[2-(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)ethyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (131) 2-(2-{[{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}(1H-imidazol-2-ylmethyl)amino]methyl}-1H-imidazol-1-yl)-N,N-dimethylacetamide, (132) N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-8-yl}methyl)benzyl]-1H-imidazole-2-carboxamide, (133) N-(1H-imidazol-2-ylmethyl)-N-(4-{[2-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}benzyl)-1H-imidazole-2-carboxamide, (134) N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-9-yl}methyl)benzyl]-1H-imidazole-2-carboxamide, (135) N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-thienylmethyl)-2,9-diazaspiro[5.5]undec-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide, (136) N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}methyl)benzyl]-1H-imidazole-2-carboxamide, (137) N-(1H-imidazol-2-ylmethyl)-N-[4-({4-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-9-yl}methyl)benzyl]-1H-imidazole-2-carboxamide, (138) N-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}-N-(1H-imidazol-2-ylmethyl)-1H-imidazole-2-carboxamide, (139) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]benzyl}methanamine, (140) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}carbonyl)benzyl]methanamine, (141) 1-(4-{[8-(2-ethylbutyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (142) 1-{4-[(8-cyclopentyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (143) 1-(4-{[8-(cyclohexylmethyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (144) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[8-(2-methylbenzyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}benzyl)methanamine, (145) 1-(4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (146) 1-{4-[(9-cyclohexyl-3,9-diazaspiro[5.5]undec-3-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (147) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-thienylmethyl)-3,9-diazaspiro[5.5]undec-3-yl]carbonyl}benzyl)methanamine, (148) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}carbonyl)benzyl]methanamine, (149) 1-{4-[(8-cycloheptyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (150) 1-(4-{[8-(cyclopentylmethyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (151) 1-(4-{[8-(cyclopropylmethyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (152) 1-{4-[(2-cyclohexyl-2,7-diazaspiro[3.5]non-7-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (153) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({7-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-2-yl}carbonyl)benzyl]methanamine, (154) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({2-[(3-methyl-2-thienyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}carbonyl)benzyl]methanamine, (155) 1-{4-[(7-cyclohexyl-2,7-diazaspiro[3.5]non-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (156) 1-{4-[(9-cyclohexyl-2,9-diazaspiro[5.5]undec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (157) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-4-yl}carbonyl)benzyl]methanamine, (158) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(7-isobutyl-2,7-diazaspiro[3.5]non-2-yl)carbonyl]benzyl}methanamine, (159) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(2-isobutyl-2,7-diazaspiro[3.5]non-7-yl)carbonyl]benzyl}methanamine, (160) 1-(4-{[8-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (161) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(8-isopropyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]benzyl}methanamine, (162) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(9-isobutyl-2,9-diazaspiro[5.5]undec-2-yl)carbonyl]benzyl}methanamine, (163) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methyl-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}carbonyl)benzyl]methanamine, (164) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)carbonyl]benzyl}methanamine, (165) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(9-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]benzyl}methanamine, (166) 1-{4-[(9-cyclohexyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (167) 1-(1H-imidazol-2-yl)-N-{4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]benzyl}-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (168) 1-(1H-imidazol-2-yl)-N-{4-[(9-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]benzyl}-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (169) 1-(1H-imidazol-2-yl)-N-{4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)carbonyl]benzyl}-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (170) 1-{4-[(9-cyclopentyl-2,9-diazaspiro[5.5]undec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (171) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(tetrahydro-2H-pyran-4-yl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}benzyl)methanamine, (172) 1-[4-({8-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}carbonyl)phenyl]-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (173) 1-(4-{[9-(2-ethylbutyl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (174) 1-(4-{[9-(2,2-dimethylpropyl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (175) 1-(4-{[9-(cyclohexylmethyl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (176) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(2-methylbenzyl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}benzyl)methanamine, (177) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methoxy-2-thienyl)methyl]-2,9-diazaspiro[5.5]undec-2-yl}carbonyl)benzyl]methanamine, (178) 1-(4-{[9-(1-ethylpropyl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (179) 1-{4-[(9-cycloheptyl-2,9-diazaspiro[5,5]undec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (180) (2-{[2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzoyl)-2,9-diazaspiro[5.5]undec-9-yl]methyl}-3-thienyl)methanol, (181) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(1-oxidotetrahydro-2H-thiopyran-4-yl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}benzyl)methanamine, (182) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(tetrahydro-2H-thiopyran-4-yl)-2,9-diazaspiro[5.5]undec-2-yl]carbonyl}benzyl)methanamine, (183) 1-{4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]phenyl}-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (184) 1-{4-[(9-isobutyl-3,9-diazaspiro[5.5]undec-3-yl)carbonyl]phenyl}-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (185) 1-(4-{[9-(1-ethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (186) 1-(4-{[9-(2,2-dimethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (187) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({9-[(3-methoxy-2-thienyl)methyl]-1-oxa-4,9-diazaspiro[5.5]undec-4-yl}carbonyl)benzyl]methanamine, (188) (2-{[4-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzoyl)-1-oxa-4,9-diazaspiro[5.5]undec-9-yl]methyl}-3-thienyl)methanol, (189) 1-{4-[(9-cycloheptyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (190) 1-{4-[(9-cyclopentyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (191) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-(4-{[9-(tetrahydro-2H-pyran-4-yl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}benzyl)methanamine, (192) 1-(4-{[9-(cyclohexylmethyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (193) 1-{4-[(9-isobutyl-1-oxa-4,9-diazaspiro[5.5]undec-4-yl)carbonyl]phenyl}-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (194) 1-{4-[2-(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)-2-oxoethyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (195) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[2-(8 isobutyl-2,8-diazaspiro[4.5]dec-2-yl)-2-oxoethyl]benzyl}methanamine, (196) 1-(4-{[7-(1-ethylpropyl)-2,7-diazaspiro[3.5]non-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (197) 1-(4-{[7-(2,2-dimethylpropyl)-2,7-diazaspiro[3.5]non-2-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (198) 1-(4-{[2-(2,2-dimethylpropyl)-2,7-diazaspiro[3.5]non-7-yl]carbonyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (199) 1-(4-{[9-(1-ethylpropyl)-3,9-diazaspiro[5.5]undec-3-yl]carbonyl}-phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (200) 1-{3-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (201) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{3-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]benzyl}methanamine, (202) 1-(4-{[9-(2,2-dimethylpropyl)-3,9-diazaspiro[5.5]undec-3-yl]carbonyl}-phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (203) 1-(4-{2-[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]-2-oxoethyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (204) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[2 (8 isobutyl-2,8-diazaspiro[4.5]dec-2-yl)-1,1-dimethyl-2-oxoethyl]benzyl}methanamine, (205) 1 (4-{2-[8-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]-2-oxoethyl}phenyl)-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (206) 1-(4-{[8-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}-phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (207) 1-(4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (208) 1-(4-{[9-(2,2-dimethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (209) 1-(4-{[9-(1-ethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (210) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]phenyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]methanamine, (211) 1-(1H-imidazol-2-yl)-N-{4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)carbonyl]benzyl}-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]methanamine, (212) 1-(4-{[8-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]methanamine, (213) 1-(4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]methanamine, (214) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-{4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)sulfonyl]benzyl}methanamine, (215) 1-(1H-imidazol-2-yl)-N-(1H-imidazol-2-ylmethyl)-N-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}sulfonyl)benzyl]methanamine, (216) 1-{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)sulfonyl]phenyl}-N,N-bis(1H-imidazol-2-ylmethyl)methanamine, (217) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-cyclohexyl-2,8-diazaspiro[4.5]decan-3-one, (218) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]decan-3-one, (219) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]decan-3-one, (220) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decan-3-one, (221) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-cyclohexyl-2,8-diazaspiro[4.5]decan-1-one, (222) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-isobutyl-2,8-diazaspiro[4.5]decan-1-one, (223) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]decan-1-one, (224) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decan-1-one, (225) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-9-cyclohexyl-2,9-diazaspiro[5.5]undecan-1-one, (226) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-9-isobutyl-2,9-diazaspiro[5.5]undecan-1-one, (227) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-9-(2,2-dimethylpropyl)-2,9-diazaspiro[5.5]undecan-1-one, (228) 2-(4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-9-(1-ethylpropyl)-2,9-diazaspiro[5.5]undecan-1-one (229) N-(1H-imidazol-2-ylmethyl)-4-[(2-isobutyl-2,8-diazaspiro[4.5]dec-8-yl)methyl]-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (230) 4-{[2-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (231) 4-{[2-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-8-yl]methyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzamide, (232) 4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]benzamide, (233) N-(1H-imidazol-2-ylmethyl)-4-[(8-isobutyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]benzamide, (234) 4-{[8-(1-ethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]benzamide, (235) 4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]methyl}-N-(1H-imidazol-2-ylmethyl)-N-[(1-isobutyl-1H-imidazol-2-yl)methyl]benzamide, (236) 1-(4-{[8-(2,2-dimethylpropyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}phenyl)-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (237) 1-(4-{[9-(2,2-dimethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, (238) 1-(4-{[9-(1-ethylpropyl)-1-oxa-4,9-diazaspiro[5.5]undec-4-yl]carbonyl}phenyl)-N,N-bis[(1-methyl-1H-imidazol-2-yl)methyl]methanamine, a salt thereof, or an N-oxide thereof.