Patent ID: 7619061
Filing Date: 2009-11-17
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. An isolated antigen construct wherein said antigen construct comprises a fusion protein, said fusion protein comprising a first HIV-1 Group O gp120 polypeptide fused to a second HIV-1 Group O gp41 polypeptide, further wherein the first polypeptide comprises amino acid residues 476 through 520 of SEQ ID NO:61; and still further wherein: (a) a portion of the hydrophobic region of the gp41 polypeptide has been deleted; (b) the second Group O polypeptide is from HIV-1 Group O isolate HAM112 (SEQ ID NO:61); or (c) the second polypeptide comprises an immunoreactive portion of the gp41 protein of HIV-1 Group O isolate HAM112 (SEQ ID NO:61).