Patent ID: 6037334
Filing Date: 2000-03-14
Classification: A61P,C07F

Abstract:
A compound of the formula ##STR13## wherein R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 hydroxyalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkinyl or aralkyl which comprises a phenyl, naphthyl or biphenyl group linked to a C.sub.1 -C.sub.6 alkyl chain, or R.sup.1 and R.sup.2 together are an alkylene group which, together with the oxygen atoms to which it is bound and the phosphorous atom to which the oxygen atoms are bound, forms a saturated 5-membered to 8-membered ring;R.sup.3 is (a) an amino group which is unsubstituted or substituted by at least one of C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 hydroxyalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkinyl or benzyl; (b) C.sub.1 -C.sub.6 alkyl, (c) C.sub.3 -C.sub.8 cycloalkyl or (d) an aryl residue selected from the group consisting of phenyl, biphenyl or naphthyl, which aryl residue is unsubstituted or substituted by at least one C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyloxy or halogen; andn is an integer of 1 to 4;or a pharmaceutically acceptable hydrate, solvate or salt thereof, or an optically active form thereof.