Patent ID: 6066636
Filing Date: 2000-05-23
Classification: C07D

Abstract:
A compound having the structural formula ##STR174## including all stereoisomers and pharmaceutically acceptable salts and solvates thereof,wherein Y and Z are both --N--;X is --O--, --S--, --SO--, --SO.sub.2 -- or --CH.sub.2 --;Q is ##STR175## R is (C.sub.1 -C.sub.20)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, aryl, or R.sup.8 -aryl;R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of H and (C.sub.1 -C.sub.20)alkyl;R.sup.4 is (C.sub.1 -C.sub.20)alkyl, (C.sub.3 -C.sub.12)cyclolalkyl or ##STR176## R.sup.5 is H, (C.sub.1 -C.sub.20)alkyl, --C(O)(C.sub.1 -C.sub.20)alkyl, R.sup.9 -arylcarbonyl, --SO2(C.sub.1 -C.sub.20)alkyl, R.sup.9 -arylsulfonyl --C(O)O(C.sub.1 -C.sub.20)alkyl, R.sup.9 -aryloxy-carbonyl, --C(O)NH--(C.sub.1 -C.sub.20)alkyl or R.sup.9 -arylaminocarbonyl;R.sup.6 is H or (C.sub.1 -C20)alkyl;R.sup.7 is H, (C.sub.1 -C20)alkyl, hydroxy(C.sub.1 -C.sub.20)alkyl or (C.sub.1 -C.sub.20)-alkoxy(C.sub.1 -C20)alkyl;R.sup.8 is 1-3 substituents independently selected from the group consisting of H, (C.sub.1 -C.sub.20)alkyl, halogen, hydroxy, (C.sub.1 -C.sub.20)alkoxy or hydroxy(C.sub.1 -C.sub.20)alkyl, or two adjacent R.sup.8 groups may be joined to form a (C.sub.1 -C.sub.2)alkylenedioxy group; andR.sup.9 is 1-3 substituents independently selected from the group consisting of H, (C.sub.1 -C20)alkyl, halogen, amino or (C.sub.1 -C.sub.20)alkylamino.