Patent ID: 6030989
Filing Date: 2000-02-29
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR10## wherein: A.sub.1 equals A.sub.2 and denotes a group Z--(CH.sub.2).sub.k --(NR'"").sub.q, whereinZ is pyridyl wherein the pyridyl ring is unsubstituted or substituted on one or two of the ring carbons by C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.4, oxo, oxime, O--C.sub.1-4 alkyloxime, hydroxy, N(R.sub.3).sub.2, acylamino or aminoacyl groups;R' and R"" are the same and are hydrogen, C.sub.1-4 alkylC(O)R.sub.4, C.sub.1-4 alkyl or R' and R"" are benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sub.3).sub.2 ;k is an integer from 0 to 4;R'"" denotes hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkylcarboxylic acid;q is an integer from 0 to 1;Q denotes a group ##STR11## wherein: B.sub.1 equals B.sub.2 and denotes halogen, --(CH.sub.2).sub.m --CN, --(CH.sub.2).sub.m+1 --R.sup.2, --(CH.sub.2).sub.m --R.sup.3, --(CH.sub.2).sub.m --COR.sup.2 or --(CH.sub.2).sub.m --COR.sup.3 ;R.sup.2 denotes --OR.sup.3, --N(R.sup.3).sub.2, --SR.sup.3 ;R.sup.3 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;m is independently an integer from 0 to 4;C.sub.1 equals C.sub.2 and denotes halogen, --(CH.sub.2).sub.n --CN, --(CH.sub.2).sub.n+1 --R.sup.4, --(CH.sub.2).sub.n --R.sup.5, --(CH.sub.2).sub.n --COR.sup.4 or --(CH.sub.2).sub.n --COR.sup.5 ;R.sup.4 is independently --OR.sup.5, --N(R.sup.5).sub.2, --SR.sup.5 ;R.sup.5 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;n is independently an integer from 0 to 4;D denotes --(CH.sub.2).sub.x --E--(CH.sub.2).sub.y --; whereinE denotes a mono- or bicyclic aromatic or nonaromatic ring system consisting of 5-10 carbon atoms, which is optionally mono-, poly or mixed substituted by alkyl, alkoxy, oxo, alkoxyalky, hydroxy, amino or dialkylamino; andx and y independently denote an integer from 0 to 5; with the proviso thatB.sub.1 is not identical to C.sub.1 and B.sub.2 is not identical to C.sub.2 ;and pharmaceutically acceptable salts thereof.