Patent ID: 8158808
Filing Date: 2012-04-17
Classification: A61P,C07D

Abstract:
1. A process for preparing duloxetine hydrochloride comprising (i) reacting (S)-3-(dimethylamino)-1-(2-thienyl)-1-propanol (Compound S-II) and 1-fluoronaphthalene (Compound III) and at least one alkaline metal hydroxide or alkoxide in DMSO or DMSO-cosolvent mixtures so as to form (S)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propylamine (Compound IV), wherein the process does not require the use of a phase transfer catalyst, (ii) converting Compound IV to a carbamate form via treatment with a formate, and (iii) converting the resulting carbamate form of Compound IV to its hydrochloride salt, thereby preparing duloxetine hydrochloride.