Patent ID: 8133690
Filing Date: 2012-03-13
Classification: C07K

Abstract:
1. A method for inhibiting the histone 3 lysine 4 of (H3K4) dimethylation activity of a Suppressor of variegation Enhancer of Zeste, Trithorax (SET1) protein core complex comprising the steps of exposing a peptide to a cell comprising both a tryptophan-aspartic acid repeat 5 (WDR5) and a SET1 family protein, wherein the WDR5 and SET1 family protein are components of a SET1 family core complex that has histone 3 lysine 4 dimethylation (H3K4) activity when exposed to histone protein H3 , the WDR5 having a SET receptor site (N-SET) that is N-terminal to a SET domain; wherein the peptide has fewer than twenty residues that includes SEQ ID NO. 7 where X inhibiting the H3K4 dimethylation activity of the SET1 family core complex by allowing the peptide and the WDR5 to bind such that the peptide blocks the N-SET receptor site of WDR5 , thus inhibiting the formation of the SET1 family core complex, the inhibition being relative to an identical sample that lacks the peptide.