Patent ID: 6184370
Filing Date: 2001-02-06
Classification: C07K

Abstract:
A substantially biologically pure molecule as set forth in FIG. 1 comprising:(i) a polypeptide backbone having a tertiary structure;(ii) amino acid residues constituting a binding determinant for the a chain of hLIF binding receptor inserted into said polypeptide backbone such that the arrangement of said amino acid residues in the tertiary structure of the polypeptide provides a hLIF receptor-binding face;and wherein said molecule exhibits at least about 50% hLIF-like activity as defined by the equation: ##EQU3##wherein X.sub.m is a dose of unlabelled mLIF; X.sub.h is a dose of unlabelled hLIF; and X.sub.C is a dose of said molecule required to give 50% inhibition of .sup.125 I-hLIF binding to murine LIF binding protein.