Patent ID: 7544798
Filing Date: 2009-06-09
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A process for preparing a compound of the following formula (I), or a pharmaceutically acceptable salt or ester thereof: wherein Q is a substituent of the following formula: the olefin group attached to the cyclopropyl ring is in the configuration syn to the A group as represented by the following structure: W is N; L one of L R wherein R 6 is NH—R 7 or NH—C(O)—R 7 , wherein R 7 is independently: C 1-6 alkyl, or C 3-6 cycloalkyl; R R D is a 5-atom saturated alkylene chain; and A is a carboxyl group, said process comprising the step of cyclyzing a diene compound of formula (IX) in the presence of a suitable catalyst to obtain a compound of the formula (I): and when A is a protected carboxylic acid group, optionally subjecting the compound of formula (I) to deprotection (e.g., hydrolysis) conditions to obtain a compound of formula (I) wherein A is a carboxylic acid group; and when A is a carboxyl group in the resulting compound of formula (I), optionally coupling this compound with a sulfonamide of formula R 11A SO 2 NH 2 , in which R 11A is C 1-8 -alkyl, C 3-7 -cycloalkyl or C 1-6 -alkyl-C 3-7 -cycloalkyl, in the presence of a suitable coupling agent to obtain a compound of formula (I) wherein A is -C(O)—NH—SO 2 R 11A .