Patent ID: 8663937
Filing Date: 2014-03-04
Classification: A01K,A61K,C07K,G01N

Abstract:
1. A method of identifying a compound capable of binding to a 24-hydroxylated vitamin D compound receptor, the method comprising: (a) contacting a 24-hydroxylated vitamin D compound receptor with a candidate compound wherein said 24-hydroxylated vitamin D compound receptor comprises either the amino acid sequence of SEQ ID NO: 1, or said sequence comprising conservative amino acid substitutions thereof; and (b) determining whether the candidate compound binds to the 24-hydroxylated vitamin D compound receptor, wherein binding is detected by an assay selected from the group consisting of: i) a receptor competition assay, wherein said receptor is contacted with said candidate compound, wherein said candidate compound is labeled in the presence of an excess of unlabeled 24,25(OH)