Patent ID: 6040342
Filing Date: 2000-03-21
Classification: A61K,C07B,C07C,C07D

Abstract:
A compound of Formula (I): ##STR7## wherein: Ret is selected from the group consisting of retinoyl group, a therapeutically-active retinoid carboxyl group, a group represented by the formula ##STR8## and retinoids which are C20 and C22 desmethyl vinylogs of said groups, wherein Z is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group or a cyclohexenyl group, and said phenyl or naphthyl group can be substituted with from 0 to 5 substitutents selected from the group consisting of halo, hydroxy, alkyl, alkyoxy, amino, cyano or carbalkoxy, and wherein double bonds in the polyene chain of any of said groups can have a cis or trans configuration;R is H or saturated or unsaturated group of C.sub.1 to C.sub.5 alkyl;R.sub.1 is ethyl, n-propyl or isopropyl; andpharmaceutically acceptable salts thereof, with the proviso that when Ret is 13-cis-retinoyl and R.sub.1, is n-propyl, then R cannot be H or C.sub.1 to C.sub.5 alkyl.