Patent ID: 8137970
Filing Date: 2012-03-20
Classification: A61K,A61P,C12N,C12Q,G01N

Abstract:
1. A method for inducing the differentiation of CD34 + hematopoietic stem cells into megakaryocytes and platelets, comprising the steps of (a) coculturing CD34 + hematopoietic stem cells with stromal' cells; and (b) adding the compound of the following Formula 1, wherein expression level of a gene selected from the group consisting of KLF2 (Kruppel-like factor2, NM 016270), LOC138255 (OTTHUMP00000021439, NM 001010940), GDF15 (growth differentiation factor 15, NM 004864) and INHBE (inhibin, betaE, NM 031479) is increased in CD34 + hematopoietic stem cells that are differentiated, relative to undifferentiated CD34 + hematopoietic stem cells.