Patent ID: 9074018
Filing Date: 2015-07-07
Classification: A61K,A61P,C07K

Abstract:
1. A reconstituted surfactant, comprising: (a) a phospholipid mixture; (b) a polypeptide analogue of the native surfactant protein SP-B; and (c) a polypeptide analogue of the native surfactant protein SP-C represented by formula (I): in which: Ω is M or M oxidized on the sulfur atom, I, L, or nL; p is 0 or 1 wherein said phospholipid mixture consists of: i) about 50% by weight of DPPC; ii) about 10% by weight of POPG; and iii) about 40% by weight of a naturally-derived fraction of unsaturated phospholipids essentially consisting of: all the amounts i), ii) and iii) being calculated on the total weight of the phospholipid mixture, wherein said polypeptide analogue of the native surfactant protein SP-B is represented by formula (II): wherein: θ is L, I or C; Δ is W, I or L; Ω is M, I, L, or nL; Φ is R or T; and f is an integer having a value of 0 or 1, which, when f is 0, may be in the form of a disulfide linked molecule wherein the intramolecular disulfide linkage is between the two C residues in positions 1 and 33 and/or between the two C residues in positions 4 and 27, or which, when f is 1, may be in the form of a disulfide linked molecule wherein the linkage is between the C residues at positions 8 and 40 and/or between the C residues at positions 11 and 34.