Patent ID: 8299032
Filing Date: 2012-10-30
Classification: A61P,C07K

Abstract:
1. A self-assembling peptide comprising polar amino acid residues and nonpolar amino acid residues, wherein the self-assembling peptide consists of 12 to 32 amino acid residues, comprises one or more acidic amino acid residues and one or more basic amino acid residues as the polar amino acid residues, wherein the sum of charge of the acidic amino acid residue(s) and charge of the basic amino acid residue(s), when the self-assembling peptide is in a neutral pH environment, is from −3 to −2 or +2 to +3, wherein all of the amino acids in the self-assembling peptide form a beta (β)-sheet structure in which one face consists of only nonpolar amino acid residues upon self-assembly in a neutral aqueous solution, and wherein the nonpolar amino acid residues are selected from the group consisting of alanine, glycine, leucine, isoleucine, methionine, valine, phenylalanine, and tryptophan.