Patent ID: 6727251
Filing Date: 2004-04-27
Classification: A61P,C07D

Abstract:
A compound of formula II: or a pharmaceutically acceptable salt or prodrug thereof, wherein:Z1 is nitrogen; Ry is Zâ€”R3â€² or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; Q is selected from â€”N(R4)â€”, â€”Oâ€”, â€”Sâ€”, or â€”CH(R6)â€”; R1 is T-(Ring D); Ring D is a 6-membered monocyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, said heteroaryl or heterocyclyl ring having 1-4 ring heteroatoms selected from nitrogen, oxygen or sulfur, wherein each substitutable ring carbon of Ring D is independently substituted by oxo, Tâ€”R5, or Vâ€”Zâ€”R5, and each substitutable ring nitrogen of Ring D is independently substituted by â€”R4; T is a valence bond or a C1-4 alkylidene chain, wherein when Q is â€”CH(R6)â€”, a methylene unit of said C1-4 alkylidene chain is optionally replaced by â€”Oâ€”, â€”Sâ€”, â€”N(R4)â€”, â€”COâ€”, â€”CONHâ€”, â€”NHCOâ€”, â€”SO2â€”, â€”SO2NHâ€”, â€”NHSO2â€”, â€”CO2â€”, â€”OC(O)â€”, â€”OC(O)NHâ€”, or â€”NHCO2â€”; Z is a C1-4 alkylidene chain; L is â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”N(R6)SO2â€”, â€”SO2N(R6)â€”, â€”N(R6)â€”, â€”COâ€”, â€”CO2â€”, â€”N(R6)COâ€”, â€”N(R6)C(O)Oâ€”, â€”N(R6)CON(R6)â€”, â€”N(R6)SO2N(R6)â€”, â€”N(R6)N(R6)â€”, â€”C(O)N(R6)â€”, â€”OC(O)N(R6)â€”, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2SO2â€”, â€”C(R6)2SO2â€”, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”, â€”C(R6)2N(R6)C(O)â€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”,â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, or â€”C(R6)2N(R6)CON(R6)â€”; R2 and R2â€² are independently selected from â€”R, â€”Tâ€”Wâ€”R6, or R2 and R2â€² are taken together with their intervening atoms to form a fused, 5-8 membered, unsaturated or partially unsaturated, ring having 0-3 ring heteroatoms selected from nitrogen, oxygen, or sulfur, wherein each substitutable ring carbon of said fused ring formed by R2 and R2â€² is independently substituted by halo, oxo, â€”CN, â€”NO2, â€”R7, or â€”Vâ€”R6, and each substitutable ring nitrogen of said ring formed by R2 and R2â€² is independently substituted by R4; R3â€² selected from -halo, â€”OR, â€”C(&boxH;O)R, â€”CO2R, â€”COCOR, â€”COCH2COR, â€”NO2, â€”CN, â€”S(O)R, â€”S(O)2R, â€”SR, â€”N(R4)2, â€”CON(R7)2, â€”SO2N(R7)2, â€”OC(&boxH;O)R, â€”N(R7)COR, â€”N(R7)CO2(C1-6 aliphatic), â€”N(R4)N(R4)2, â€”C&boxH;NN(R4)2, â€”C&boxH;Nâ€”OR, â€”N(R7)CON(R7)2, â€”N(R7)SO2N(R7)2, â€”N(R4)SO2R, â€”OC(&boxH;O)N(R7)2, or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; each R is independently selected from hydrogen or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; each R4 is independently selected from â€”R7, â€”COR7, â€”CO2(optionally substituted C1-6 aliphatic), â€”CON(R7)2, or â€”SO2R7; each R5 is independently selected from â€”R, halo, â€”OR, â€”C(&boxH;O)R, â€”CO2R, â€”COCOR, â€”NO2, â€”CN, â€”S(O)R, â€”SO2R, â€”SR, â€”N(R4)2, â€”CON(R4)2, â€”SO2N(R4)2, â€”OC(&boxH;O)R, â€”N(R4)COR, â€”N(R4)CO2(optionally substituted C1-6 aliphatic), â€”N(R4)N(R4)2, â€”C&boxH;NN(R4)2, â€”C&boxH;Nâ€”OR, â€”N(R4)CON(R4)2, â€”N(R4)SO2N(R4)2, â€”N(R4)SO2R, or â€”OC(&boxH;O)N(R4)2, V is â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”N(R6)SO2â€”, â€”SO2N(R6)â€”, â€”N(R6)â€”, â€”COâ€”, â€”CO2â€”, â€”N(R6)COâ€”, â€”N(R6)C(O)Oâ€”, â€”N(R6)CON(R6)â€”, â€”N(R6)SO2N(R6)â€”, â€”N(R6)N(R6)â€”, â€”C(O)N(R6)â€”, â€”OC(O)N(R6)â€”, â€”C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2SO2â€”, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”, â€”C(R6)2N(R6)C(O)â€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, or â€”C(R6)2N(R6)CON(R6)â€”; W is â€”C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2SO2â€”, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”, â€”COâ€”, â€”CO2â€”, â€”C(R6)OC(O)â€”, â€”C(R6)OC(O)N(R6)â€”, â€”C(R6)2N(R6)COâ€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, â€”C(R6)2N(R6)CON(R6)â€”, or â€”CON(R6)â€”; each R6 is independently selected from hydrogen or an optionally substituted C1-4 aliphatic group, or two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to form a 5-6 membered heterocyclyl or heteroaryl ring; and each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group, or two R7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclyl or heteroaryl ring.