Patent ID: 7794729
Filing Date: 2010-09-14
Classification: A61K,C07K,C12N

Abstract:
1. A method of treating a breast cancer in a human subject, the method comprising administering to said human subject a Listeria vaccine strain, wherein said Listeria vaccine strain comprises a nucleic acid encoding a truncated listeriolysin O (LLO) protein fused to a Her-2/neu protein fragment, wherein said truncated LLO protein comprises the sequence set forth in SEQ ID NO: 10 and does not comprise cysteine 484, wherein said Her-2/neu protein fragment consists of amino acid residues selected from the group consisting of SEQ ID NO: 4 and SEQ ID NO: 5 of said Her-2/neu protein, and wherein at least one cell of said breast cancer expresses a Her-2/neu protein, thereby treating a breast cancer in a human subject.