Patent ID: 6472200
Filing Date: 2002-10-29
Classification: A61M,A61P,C12M

Abstract:
A device for performing a biological modification of a fluid of a subject, the device comprising:(a) a chamber having an inlet for intake of the fluid from the subject and an outlet for outflow of the fluid to the subject; and (b) a collection of liver portions for performing the biological modification of the fluid, each individual liver portion of said collection including cells and having dimensions, such that cells positioned deepest within said individual liver portion are at least about 100 micrometers and not more than about 225 micrometers away from a nearest surface of said individual liver portion, said collection of liver portions being located within said chamber and said collection of liver portions being in contact with at least a portion of the fluid flowing through said chamber, wherein said collection of liver portions is cryo-preserved before being located within said chamber and further wherein viability of said collection of liver portions is maintained for at least 21 days upon operation of the device.