Patent ID: 6329351
Filing Date: 2001-12-11
Classification: A61K,C08B,Y02A

Abstract:
A process for the preparation of pharmaceutical compositions having antimetastatic activity and a reduced hemorrhagic risk, containing a sulfaminoheparosan sulfate, comprising:a) deacetylation of K5 polysaccharide from Escherichia coli to obtain deacetylated K5 polysaccharide;b) sulfation of deacetylated K5 polysaccharide obtained in step a) with sulfuric anhydride/trimethylamine adduct to obtain sulfaminoheparosan sulfate, andc) formulating said sulfaminoheparosan sulfate with conventional excipients, wherein said sulfation is carried out at 0.degree. C. for times ranging from 0.25 to 2 hours and using an adduct/polysaccharide ratio, defined as SO.sub.3 equivalents/available OH groups equivalents, equal to 5.