Patent ID: 7081469
Filing Date: 2006-07-25
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A method for treatment of a solid cancerous tumor in a mammal wherein a composition of formula I is administered to said mammal in a dosage sufficient to damage new vasculature but insufficient to exhibit anti-mitotic activity: wherein: alk is an alkyl group; X is oxygen, sulfur, sulphinyl, sulphonyl, carbonyl (CO), thiocarbonyl (CS), sulphonyloxy, NH, iminomethylene (C═NH), N-hydroxyiminomethylene, N-alkoxyiminomethylene, dialkoxymethylene, 1,3-dioxolan-2yl, 1,1-ethenyl, a group CHR R R R A is a substituted aromatic or substituted alkyl group; wherein the substituent on A is selected from phosphate, alkylphosphate, NHC(O)R R prodrugs and pharmaceutically acceptable salts, solvates and hydrates thereof.