Patent ID: 6025384
Filing Date: 2000-02-15
Classification: C07D

Abstract:
A method for the treatment of inflammatory disorders in a host comprising administering an effective amount of a compound of formula: ##STR30## wherein: Ar is an aryl or heteroaryl group that is optionally substituted with halo, lower alkoxy, lower aryloxy, W, cyano, or R.sup.3 ;m is 0 or 1;n is 1-6;W is independently --AN(OM)C(O)N(R.sup.3)R.sup.4, --N(OM)C(O)N(R.sup.3)R.sup.4, --AN(R.sup.3)C(O)N(OM)R.sup.4, --N(R.sup.3)C(O)N(OM)R.sup.4 --AN(OM)C(O)R.sup.4, --N(OM)C(O)R.sup.4 --, AC(O)N(OM)R.sup.4, --C(O)N(OM)R.sup.4, --C(O)NHA;A is lower alkyl, lower alkenyl, lower alkynyl, alkylaryl or arylalkyl groups, wherein one or more carbons optionally can be replaced by O, N, or S (with valence completed with hydrogen or oxygen as necessary), however, --Y--A--, --A--, or --AW-- should not include two adjacent heteroatoms (i.e., --O--O--, --S--S--, --O--S--, etc.);M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable leaving group;X is O, S, S(O), S(O).sub.2, NR.sup.3, or CHR.sup.5 ;Y is O, S, S(O), S(O).sub.2, NR.sup.3, or CHR.sup.5 ;Z is O, S, S(O), S(O).sub.2, NR.sup.3 ;R.sup.1 and R.sup.2 are independently hydrogen, lower alkyl, cyclopropylmethyl, ethyl, isopropyl, butyl, pentyl hexyl, and C.sub.3-8 cycloalkyl, for example, cyclopentyl; halo lower alkyl, halo, or --COOH;R.sup.3 and R.sup.4 independently hydrogen or alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkylaryl, C.sub.1-6 alkoxy-C.sub.1-10 alkyl, C.sub.1-6 alkylthio-C.sub.1-10 alkyl, heteroaryl, or heteroarylalkyl-; andR.sup.5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, arylalkyl, alkylaryl, --AN(OM)C(O)N(R.sup.3)R.sup.4, --AN(R.sup.3)C(O)N(OM)R.sup.4, --AN(OM)C(O)R.sup.4, --AC(O)N(OM)R.sup.4, --AS(O)xR.sup.3, --AS(O).sub.n CH.sub.2 C(O)R.sup.3, --AS(O).sub.n CH.sub.2 CH(OH)R.sup.3, or --AC(O)NHR.sup.3, wherein x is 0-2.