Patent ID: 6187930
Filing Date: 2001-02-13
Classification: A61P,C07D

Abstract:
A process for resolving 2-[phenyl(1-methyl-1 H-pyrazole-5-yl)methoxy]-N,N-dimethylethanamine of formula I ##STR3##into its enantiomers comprising the steps of:a) reacting 2-[phenyl(1-methyl-1 H-pyrazole-5-yl)methoxy]-N,N-dimethylethanamine with an optically active acid selected from (+)-ditoluyl-L-tartaric acid, (-)-ditoluyl-L-tartaric acid or a mixture thereof in a solvent to form a diastereoisomeric salt between one of the enantiomers of formula (I) and one of (+)ditoluyl-L-tartaric acid or (-)ditoluyl-L-tartaric acid;b) separating the diastereoisomeric salt andc) isolating the enantiomer of 2-[phenyl(1-methyl-1-pyrazole-5-yl)methoxy]-N,N-dimethylethanamine.