Patent ID: 6410585
Filing Date: 2002-06-25
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
Compounds of formula I wherein G1 isa) â€”R2; wherein G2 isc) CH2OH; wherein R1 isa) â€”OSO3H, b) â€”OCH(CO2R5)2, c) â€”OCH2(CO2R5), d) â€”OCH(CO2R5)CH2CO2R5, e) â€”OC(CO2R5)&boxH;CHCO2R5, f) â€”CH2CH(CO2R5)2, g) â€”CH&boxH;C(CO2R5)2, h) â€”OCH2CONHOH, i) â€”N(CH2CO2R5)2, or j) â€”OCHF(CO2R5); wherein R2 isd) â€”CH(R7)NHXR6, or e) wherein R5 isa) â€”H, b) â€”C1-C10 alkyl, or c) â€”C1-C5 alkyl-phenyl; wherein R6 isa) C1-C10 alkyl, b) C0-C6 alkyl-G3, c) C1-C6 alkyl CONH2, d) C1-C6 alkyl NHCO2R5, e) C1-C6 alkyl-OR5, f) C1-C6 alkyl-NHSO2Me, g) C1-C6 alkyl-Oâ€”G3, h) C1-C6 alkyl-Sâ€”G3, or i) â€”C1-C6 alkyl-CO2R5; wherein R7 isa) â€”H, b) â€”C1-C6 alkyl-G3, c) â€”C1-C6 alkyl-CO2R5, d) C1-C6 alkyl CONH2, e) C1-C6 alkyl NHCO2R5, f) C1-C10 alkyl, g) C1-C10 cycloalkyl, h) â€”C1-C6 alkyl-SR , or i) â€”C1-C6 alkyl-S(&boxH;O)R5; wherein G3 isa) phenyl substituted by zero (0) to three (3) R9, b) naphthyl substituted by zero (0) to three (3) R9, or c) het1 substituted by zero (0) to three (3) R9; wherein het1 is a 5- or 6-membered saturated or unsaturated ring containing from one (1) to four (4) heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and including any bicyclic group in which any of the above heterocyclic rings is fused to a benzene ring, C3-C8 cycloalkyl, or another heterocycle; and optionally, the nitrogen and sulfur heteroatoms may be in oxidized form;wherein R9 may be any of the following:a) C1-C8 alkyl substituted by zero (0) to three (3) halo, b) C2-C8 alkenyl, c) OH, d) Oâ€”C1-C5 alkyl, e) Oâ€”C0-C5 alkyl-phenyl, e) â€”(CH2)nâ€”Oâ€”C1-C5 alkyl substituted by zero (0) to three (3) hydroxy, f) â€”(CH2)nâ€”Oâ€”C2-C7 alkenyl substituted by zero (0) to three (3) hydroxy, g) halo, h) NH2, i) amino-C1-C5 alkyl, j) mono- or di-C1-C5 alkylamino, k) â€”C(O)â€”C1-C5 alkyl, l) â€”CHO, m) â€”C(O)â€”C0-C5 alkyl-phenyl, n) â€”COOR5, o) â€”CON(R5)2, p) â€”C3-C7 cycloalkyl, q) â€”NO2, r) â€”CN, s) â€”SO3H, t) â€”SO2N(R5)2, u) â€”O[(CH2)2â€”O]nâ€”CH3, v) â€”[CH2â€”O]nâ€”C1-C3 alkyl, w) â€”NR5(CO)â€”NR5, x) â€”CF3, y) â€”NR5(CO)C1-C5 alkyl, z) â€”N(R5)â€”SO2â€”R5, a1) â€”Oâ€”C(O)â€”R5, b1) â€”S(O)â€”R5, c1) â€”SR5, or d1) â€”SO2â€”R5; wherein R10 isa) â€”H, b) CO2R5, c) CONHOH, d) 5-tetrazolyl, e) F, or f) OCH2CO2R5; wherein R11 isa) H; wherein X is â€”COâ€” or â€”SO2â€” or â€”CO2â€”;wherein n is zero, one, two or three;or a pharmaceutically acceptable salt thereof;provided that when R10 is H, R1 is other than â€”OCH2(CO2R5).