Patent ID: 7713966
Filing Date: 2010-05-11
Classification: A61P,C07D

Abstract:
1. A compound having Formula (I): wherein: R wherein R wherein R R R wherein each R wherein each R wherein optionally two R optionally two R R R R wherein each R wherein each R R R R wherein cycloalkyl, heterocycloalkyl, bicycloalkyl, heterobicycloalkyl, spiroalkyl, spiroheteroalkyl, aryl, heteroaryl, cycloalkyl fused aryl, heterocycloalkyl fused aryl, cycloalkyl fused heteroaryl, heterocycloalkyl fused heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, bicycloalkylalkyl, heterobicycloalkylalkyl, spiroalkylalkyl, spiroheteroalkylalkyl, arylalkyl, heteroarylalkyl, cycloalkyl fused arylalkyl, heterocycloalkyl fused arylalkyl, cycloalkyl fused heteroarylalkyl, and heterocycloalkyl fused heteroarylalkyl are optionally substituted one or more times; R R R E is selected from a bond, CR L L Q is a 4- to 8-membered ring selected from cycloalkyl, heterocycloalkyl or a 5- or 6-membered ring selected from aryl and heteroaryl, wherein Q is optionally substituted one or more times, or wherein Q is optionally substituted one or more times with R U is selected from C(R W X is selected from a bond and (CR X g and h are independently selected from 0-2; w is selected from 0-4; x is selected from 0 to 2; y is selected from 1 and 2; the dotted line optionally represents a double bond; and N-oxides, pharmaceutically acceptable salts, formulations, tautomers, racemic mixtures and stereoisomers thereof.