Patent ID: 6608192
Filing Date: 2003-08-19
Classification: A61P,C07D,Y02P

Abstract:
A compound of formula (I): wherein:X is selected from COOH, NHZ, SH, or OH, where Z is either H or an amine protecting group; A is O, S, NH, or a single bond; R2 and R3 are independently selected from: H, R, OH, OR, &boxH;O, &boxH;CHâ€”R, &boxH;CH2, CH2â€”CO2R, CH2â€”CO2H, CH2â€”SO2R, Oâ€”SO2R, CO2R, COR, CN and there is optionally a double bond between C1 and C2 or C2 and C3; R6, R7, and R9 are independently selected from H, R, OH, OR, halo, nitro, amino, and Me3Sn; R11 is either H or R; Q is S, O or NH; R10 is a nitrogen protecting group; where R is selected from the group consisting of a lower alkyl group having 1 to 10 carbon atoms and optionally contains one or more carbon-carbon double or triple bonds, which may form part of a conjugated system; an alkyl-C(O)-alkyl group having 3 to 10 carbon atoms; an alkyl-O-alkyl group having 2 to 10 carbon atoms; an alkyl-S-alkyl group having 2 to 10 carbon atoms; an aralkyl group of up to 12 carbon atoms, wherein an alkyl group of the aralkyl group optionally contains one or more carbon-carbon double or triple bonds, which may form part of a conjugated system; and an aryl group of up to 12 carbon atoms; and where R is optionally substituted by one or more halo, hydroxy, amino, or nitro groups; and Y is a divalent group selected from the group consisting of a lower alkylene group having 1 to 10 carbon atoms, which optionally contains one or more carbon-carbon double or triple bonds, which may form part of a conjugated system; an alkylene-C(O)- alkylene group having 3 to 10 carbon atoms; an alkylene-O-alkylene group having 2 to 10 carbon atoms; an alkylene-S-alkylene group having 2 to 10 carbon atoms; an aralkylene group of up to 12 carbon atoms wherein an alkylene portion of the aralkylene group optionally contains one or more carbon-carbon double or triple bonds which may form part of a conjugated system; or an arylene group of up to 12 carbon atoms; and wherein Y is optionally substituted by one or more halo, hydroxy, amino or nitro groups.