Patent ID: 6339070
Filing Date: 2002-01-15
Classification: A61K,A61P,B82Y,C07K,C12N,Y10S

Abstract:
A matched two component system designed for use in a mammalian host in which the components comprise:(i) a first component that comprises a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme and a secretory leader sequence for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and heterologous prodrug activating enzyme and the secretory leader sequence as a conjugate within a cell in the mammalian host and wherein the conjugate is directed by the secretory leader sequence to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety; and (ii) a second component that comprises a prodrug which can be converted into a cytotoxic drug by the heterologous enzyme encoded by the first component.