Patent ID: 6759412
Filing Date: 2004-07-06
Classification: A61P,C07C

Abstract:
A compound of formula (I) in any of its stereoisomeric forms or a mixture thereof in any ratio or a pharmaceutically acceptable salt thereof whereinR1 and R4 are independently from each other chosen from: H; unsubstituted and at least monosubstituted C1-C10-alkyl, C2-C10-alkenyl and C2-C10-alkynyl, the substituents of which are chosen from, F, OH, C1-C8-alkoxy, (C1-C8-alkyl)mercapto, CN, COOR6, CONR7R8, and unsubstituted and at least monosubstituted phenyl and heteroaryl, the substituents of which are chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3; unsubstituted and at least monosubstituted phenyl and heteroaryl, the substituents of which are chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3; R9CO; CONR1OR11; COOR12; CF3; halogens; pseudohalogens; NR13R14; OR15; S(O)mR16; SO2NR17R18; and NO2; R2 and R3 are independently from each other chosen from: H; halogens; pseudohalogens; unsubstituted and at least monosubstituted C1-C10-alkyl, the substituents of which are chosen from OH, phenyl, and heteroaryl; OH; C1-C10-alkoxy; phenoxy; S(O)mR19; CF3; CN; NO2; (C1-C10-alkyl)amino; di(C1-C10-alkyl)amino; (C1-C6-alkyl)-CONHâ€”; unsubstituted and at least monosubstituted phenyl-CONHâ€” and phenyl-SO2â€”Oâ€”, the substituents of which are chosen from halogens, pseudohalogens, CH3 and methoxy; (C1-C6-alkyl)SO2â€”Oâ€”; unsubstituted and at least monosubstituted (C1-C6-alkyl)CO, the substituents of which are chosen from F, di(C1-C3-alkyl)amino, pyrrolidinyl and piperidinyl; and phenyl-CO, the phenyl part of which can be substituted by one or more substituents chosen from C1-C3-alkyl, halogens and methoxy; A is chosen from CH2, CHOH and CHâ€”(C1-C3-alkyl); B is chosen from CH2 and CHâ€”(C1-C3-alkyl); C independently has the same meaning as B; D independently has the same meaning as B; R5 is a group Ar or a group Hetar both of which can be unsubstituted or carry one or more substituents chosen from: halogens; pseudohalogens; NH2; unsubstituted and at least monosubstituted C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C1-C10-alkoxy, (C1-C10-alkyl)amino, and di(C1-C10-alkyl)amino, the substituents of which are chosen from F, OH, C1-C8-alkoxy, aryloxy, (C1-C8-alkyl)mercapto, NH2, (C1-C8-alkyl)amino, and di(C1-C8-alkyl)amino; C3-C5-alkandiyl; phenyl; heteroaryl; aryl- or heteroaryl-substituted C1-C4-alkyl; CF3; NO2; OH; phenoxy; benzyloxy; (C1-C10-alkyl)COO; S(O)mR20; SH; phenylamino; benzylamino; (C1-C10-alkyl)-CONHâ€”; (C1-C10-alkyl)-CON(C1-C4-alkyl)-; phenyl-CONHâ€”; phenyl-CON(C1-C4-alkyl)-; heteroaryl-CONHâ€”; heteroaryl-CON(C1-C4-alkyl)-; (C1-C10-alkyl)-CO; phenyl-CO; heteroaryl-CO; CF3â€”CO; â€”OCH2Oâ€”; â€”OCF2Oâ€”; â€”OCH2CH2Oâ€”; â€”CH2CH2Oâ€”; COOR21; CONR22R23; CNH(NH2); SO2NR24R25; R26O2NHâ€”; R27SO2N(C1-C6-alkyl)-; and saturated and at least monounsaturated aliphatic, mononuclear 5- to 7-membered heterocycles containing 1 to 3 heteroatoms chosen from of N, O, and S, which heterocycles can be substituted by one or more substituents chosen from halogens, C1-C3-alkyl, C1-C3-alkoxy, OH, oxa and CF3, and wherein said heterocycles can optionally be condensed to said group Ar or said group Hetar; and wherein all aryl, heteroaryl, phenyl, aryl-containing, heteroaryl-containing and phenyl-containing groups, which are optionally present in said substituents of said group Ar or said group Hetar, can be substituted by one or more substituents chosen from halogens, pseudohalogens, C1-C3-alkyl, OH, C1-C3-alkoxy, and CF3; R6 is chosen from: H; C1-C10-alkyl, which can be substituted by one or more substituents chosen from F, C1-C8-alkoxy, and di(C1-C8-alkyl)amino; aryl-(C1-C4-alkyl) and heteroaryl-(C1-C4-alkyl), which can be substituted by one or more substituents chosen from halogens, C1-C4-alkoxy, and di(C1-C6-alkyl)amino; R7 is chosen from: H; C1-C10-alkyl which can be substituted by one or more substituents chosen from F, C1-C8-alkoxy, di(C1-C8-alkyl)amino and phenyl; phenyl; indanyl; and heteroaryl; and wherein each of the aforementioned aromatic groups can be unsubstituted or carry one or more substituents chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3; R8 is H or C1-C10-alkyl; R9 is chosen from: C1-C10-alkyl which can be unsubstituted or carry one or more substituents chosen from: F, (C1-C4)-alkoxy, di(C1-C3-alkyl)amino; and unsubstituted and at least monosubstituted phenyl and heteroaryl, the substituents of which are chosen from C1-C3-alkyl, C1-C3-alkoxy, halogens, pseudohalogens, and CF3; R10 independently has the same meaning as R7; R11 independently has the same meaning as R8; R12 independently has the same meaning as R6; R13 is chosen from: H; C1-C6-alkyl; unsubstituted and substituted phenyl, benzyl, heteroaryl, (C1-C6-alkyl)-CO, phenyl-CO, and heteroaryl-CO, the substituents of which are chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy, and CF3, and wherein one or more of these substituents can be present; R14 independently has the same meaning as R13; R15 is chosen from: H; C1-C10-alkyl; (C1-C3-alkoxy)-C1-C3-alkyl; and substituted and unsubstituted benzyl, phenyl and heteroaryl, the substituents of which are chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy, and CF3, and wherein one or more of these substituents can be present; R16 is chosen from: C1-C10-alkyl which can be substituted by one or more substituents chosen from F, OH, C1-C8-alkoxy, aryloxy, (C1-C8-alkyl)mercapto, (C1-C8-alkyl)amino and di(C1-C8-alkyl)amino; CF3; and substituted and unsubstituted phenyl and heteroaryl, the substituents of which are chosen from halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3, and wherein one or more of these substituents can be present; R17 independently has the same meaning as R7; R18 independently has the same meaning as R8; R19 independently has the same meaning as R16; R20 independently has the same meaning as R16; R21 independently has the same meaning as R6; R22 independently has the same meaning as R7; R23 independently has the same meaning as R8; R24 independently has the same meaning as R7; R25 independently has the same meaning as R8; R26 independently has the same meaning as R16; R27 independently has the same meaning as R16; heteroaryl is a 5 to 10-membered, aromatic, mono- or bicyclic heterocycle containing one or more heteroatoms chosen from N, O, and S; the group Hetar is a 5 to 10-membered, aromatic, mono- or bicyclic heterocycle containing one or more heteroatoms chosen from of N, O, and S; aryl is phenyl, naphth-1-yl or naphth-2-yl; the group Ar is phenyl, naphth-1-yl or naphth-2-yl; and m is 0, 1 or 2.