Patent ID: 9150926
Filing Date: 2015-10-06
Classification: A61P,C12N,C12Q

Abstract:
1. A method of distinguishing malignant adrenocortical tumor from a benign adrenocortical tumor, comprising: providing an adrenocortical tumor sample measuring expression of at least one microRNA (miR) gene product, RNU4-8 and IGF2 mRNA in the adrenocortical tumor sample, wherein the at least one miR gene product comprises at least miR-483-5p; and identifying a malignant adrenocortical tumor, with a positive predictive value of 100% and a negative predictive value of 92% by detecting increased expression in at least one miR-483-5p relative to RNU48 expression and increased expression in IGF2 mRNA compared to a control in the tumor sample.