Patent ID: 7435419
Filing Date: 2008-10-14
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method of diagnosing a pregnant human subject as having, or having a propensity to develop, pre-eclampsia or eclampsia, said method comprising: (a) measuring the level of free PlGF in a urine sample from said pregnant human subject, wherein said free PlGF is a PlGF polypeptide that has the ability to bind to sFlt-1; and (b) measuring the level of sFlt-1 in a bodily fluid sample from said pregnant human subject; wherein a level of free PlGF in said urine sample less than 400 pg/ml and a level of sFlt-1 polypeptide greater than 2 ng/ml measured during mid-gestation or late gestation is a diagnostic indicator of pre-eclampsia or eclampsia or a propensity to develop pre-eclampsia or eclampsia.