Patent ID: 7217421
Filing Date: 2007-05-15
Classification: A61K

Abstract:
1. A composition for generating an immune response to a human prostate tumor-associated antigen in a human subject, comprising: a proliferation-incompetent cell engineered to express GM-CSF selected from LnCaP and PC3, wherein said composition is capable of eliciting a humoral immune response to a prostate tumor-associated antigen with a molecular weight selected from the group consisting of 250 kD, 160 kD, 150 kD. 31 kD, 26 kD and 14 kD, as detected by SDS-PAGE, wherein said humoral immune response is not detected in said human subject prior to administering said composition and said prostate tumor-associated antigen does not cross-react immunologically with prostate-specific antigen.