Patent ID: 7968583
Filing Date: 2011-06-28
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: R is an optionally further substituted straight or branched C R1 is selected from NHCOR4, NHSO R4 is selected from an optionally further substituted heterocycloalkyl, aryl, NR8R9, and R7O—C R5 is hydrogen, an optionally further substituted straight or branched C R6, is an optionally further substituted straight or branched C R7 is selected from hydrogen, an optionally further substituted straight or branched C R8 and R9, being the same or different, are independently selected from hydrogen, an optionally further substituted straight or branched C R10 is an optionally further substituted straight or branched C A, B, D and E represent a nitrogen atom, CH, CR2 or CR3, with a maximum of two of A, B, D and E representing a nitrogen atom, and with a maximum of two of A, B, D and E representing CR2 or CR3, wherein: R2 and R3, being the same or different, are independently selected from halogen, trifluoromethyl, nitro, OR7, NR8R9, an optionally further substituted straight or branched C Ra and Rb, being the same or different, are selected from hydrogen or methyl, with the proviso that: when A, D and E are CH, and B is CR2, wherein R2 is 4-methylpiperazine or morpholine, then R1 is not NHCOR4 wherein R4 is pyrrolidin-2-yl; or isomers, tautomers, carriers, and pharmaceutically acceptable salt thereof.