Patent ID: 9161992
Filing Date: 2015-10-20
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A conjugate, comprising a p97 polypeptide that consists of at least one of SEQ ID NO:1-8 or 9 or a sequence having at least 95% identity along its length to SEQ ID NO:1-8 or 9 or a sequence that differs from SEQ ID NO:1-8 or 9 by the addition or deletion of about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 N-terminal and/or C-terminal residues, where the p97 polypeptide is covalently or operatively linked to (a) etanercept or an antigen-binding fragment or variant thereof that specifically binds to tumor necrosis factor (TNF)-α, or (b) an antibody or antigen-binding fragment thereof that specifically binds to amyloid-β(Aβ).