Patent ID: 6476060
Filing Date: 2002-11-05
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinR represents phenyl, thienyl or pyridyl, each of which is unsubstituted or substituted with 1, 2 or 3 substituents Y, which are the same or different and are chosen from C1-3-alkyl, C1-3-alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, monoalkyl (C1-2)-amino, dialkyl (C1-2)-amino, monoalkyl (C1-2)-amido, dialkyl (C1-2)-amido, (C1-3)-alkyl sulfonyl, dimethylsulfamido, C1-3-alkoxycarbonyl, carboxyl, trifluoromethylsulfonyl, cyano, carbamoyl, sulfamoyl and acetyl, orR represents naphthyl, R1 represents phenyl, thienyl or pyridyl, each of which is unsubstituted or substituted with 1, 2 or 3 substituents Y, which are the same or different and are chosen from C1-3-alkyl, C1-3-alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, monoalkyl (C1-2)-amino, dialkyl (C1-2)-amino, monoalkyl (C1-2)-amido, dialkyl (C1-2)-amido, (C1-3)-alkyl sulfonyl, dimethylsulfamido, C1-3-alkoxycarbonyl, carboxyl, trifluoromethylsulfonyl, cyano, carbamoyl, sulfamoyl and acetyl, orR1 represents naphthyl, R2 represents hydrogen, hydroxy, C1-3-alkoxy, acetyloxy or propionyloxy, Aa represents one of groups (i), (ii), (iii), (iv) or (v) whereinR4 represents hydrogen, C1-8 branched or unbranched alkyl or C3-8 cycloalkyl; and when R5 represents hydrogen, R4 optionally further represents acetamido, dimethylamino, 2,2,2-trifluoroethyl, phenyl or pyridyl, R5 represents hydrogen, C1-8 branched or unbranched alkyl or C3-8 cycloalkyl, R6 represents hydrogen or C1-3 unbranched alkyl, Bb represents sulfonyl or carbonyl, R3 represents benzyl, phenyl, thienyl or pyridyl, each of which is unsubstituted or substituted with 1, 2 or 3 substituents Y, which are the same or different, or R3 represents C1-8 branched or unbranched alkyl or C3-8 cycloalkyl, or R3 represents naphthyl.