Patent ID: 6121266
Filing Date: 2000-09-19
Classification: A61P,C07D

Abstract:
A method of inhibiting interleukin-1.beta. protease activity in a mammal in need of such treatment comprising administering to said mammal an effective inhibitory amount of a pharmaceutical composition comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR27## wherein: R.sub.1 is halogen;R.sub.2 is OR.sub.5, NH(CHR.sub.5).sub.m --COOR.sub.5, NH(CHR.sub.5).sub.m CON(R.sub.5)R.sub.6, N(R.sub.5)R.sub.6 or NH(CHR.sub.5).sub.m OH;R.sub.3 is H or alkyl;R.sub.4 is H; substituted or unsubstituted aryl, heteroaryl, or alkyl;R.sub.5 and R.sub.6 are independently H, lower alkyl, aryl, hydroxy alkyl, amino alkyl, heteroaryl, lower alkylene-aryl, lower alkylene-heteroaryl or lower cycloalkyl; andm is 0-6in a pharmaceutically acceptable carrier.