Patent ID: 7879977
Filing Date: 2011-02-01
Classification: C07K

Abstract:
1. A modified peanut allergen protein whose amino acid sequence differs from that of an intact wild-type peanut allergen protein in that at least one IgE epitope has a substitution in the modified peanut allergen protein such that the modified peanut allergen protein has a reduced ability to bind or crosslink IgE as compared with the unmodified peanut allergen protein, the at least one IgE epitope being one that is recognized when the unmodified peanut allergen protein is contacted with serum IgE from an individual that is allergic to the unmodified peanut allergen protein, wherein: when the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 2, the substitution is in an IgE epitope selected from the group consisting of: when the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 4, the substitution is in an IgE epitope selected from the group consisting of: when the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 6, the substitution is in an IgE epitope selected from the group consisting of: