Patent ID: 8338406
Filing Date: 2012-12-25
Classification: A61P,C07D

Abstract:
1. A benzodiazepine compound of Formula (1) or a pharmaceutically acceptable salt thereof, wherein R R A R wherein R (4-1) cyano, (4-2) hydroxy, (4-3) halogen, (4-4) lower alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, imidazolyl, morpholinyl, and lower alkoxy, (4-5) lower alkoxy optionally substituted with one or more substituents selected from the group consisting of amino and lower alkyl amino, (4-6) pyridyl, (4-7) thienyl, (4-8) piperazinyl optionally substituted with one or more lower alkyl, (4-9) phenyl optionally substituted with one or more substituents selected from the group consisting of amino and lower alkoxy, (4-10) pyrazolyl optionally substituted with one or more lower alkyl, (4-11) pyrimidinyl optionally substituted with one or more lower alkyl, (4-12) piperidyl optionally substituted with one or more lower alkyl, (4-13) furyl, (4-14) carboxy, (4-15) lower alkoxycarbonyl, (4-16) amino optionally substituted with one or more substituents selected from the group consisting of lower alkanoyl, lower alkylsulfonyl, and lower aykyl, (4-17) lower alkylthio, (4-18) triazolyl, (4-19) imidazolyl, (4-20) pyrrolidinyl optionally substituted with one or more oxo, (4-21) lower alkylsulfonyl, (4-22) lower alkylenedioxy optionally substituted with one or more halogen, (4-23) nitro, (4-24) oxazolyl, (4-25) thiazolyl optionally substituted with one or more lower alkyl, (4-26) sulfo, (4-27) pyridyloxy, (4-28) lower alkylenedioxy, (4-29) lower alkanoylamino, (4-30) oxo, (4-31) morpholinyl, and (4-32) lower alkanoyl; X