Patent ID: 8999919
Filing Date: 2015-04-07
Classification: A61K,A61P,C07K

Abstract:
1. A method for increasing cell surface expression of a degradation-prone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein comprising contacting a cell expressing a degradation-prone CFTR with an effective amount of a peptide comprising the amino acid sequence of (M/F/L/A/W)-(Q/P/F)-(S/T)-(S/T)-(K/I)-I (SEQ ID NO:1) or SEQ ID NO:24, or a derivative or peptidomimetic thereof, that selectively inhibits the interaction between the degradation-prone CFTR and CFTR-Associated Ligand thereby increasing cell surface expression of the degradation-prone CFTR protein as compared to cell surface expression in the absence of the agent.