Patent ID: 7713994
Filing Date: 2010-05-11
Classification: A61P,C07D

Abstract:
1. A compound having the Formula (I) or a pharmaceutically acceptable salt thereof, A A PEG is —(OCH Y Y L R R R wherein said aryl, said heteroaryl, and said heterocycloalkyl are each optionally substituted with up to four independently selected R wherein said C R R R wherein said C wherein said C wherein said aryl and said heteroaryl are optionally substituted with up to three R wherein R R wherein said C R wherein said aryl, heteroaryl, and heterocycloalkyl are optionally substituted with up to three independently selected R R wherein said R R R R R R R R R R R R R R R R R R R R R R R R R wherein said C wherein said arylalkyl and said heteroarylalkyl are each optionally substituted with up to three independently selected R wherein said C wherein said heterocycloalkyl is optionally substituted with up to three independently selected C R R R R R R R R e is 1 provided that R f is 0-5; k′ is 1-6; m is 0, 1, or 2; n is 1-4; q is 1-3; r is 2-1800; G  NHC(O)R wherein said aryl, said heteroaryl, and said heterocycloalkyl are each optionally substituted with up to four independently selected R wherein said C Q is —NR Q″ is selected from the group consisting of O, S, and NH; Z is selected from the group consisting of aryl, heteroaryl, cycloalkyl, heterocycle, pyridone, and pyrone, wherein said aryl, said pyridone, said pyrone, said cycloalkyl, said heteroaryl, and said heterocycle are each optionally substituted with up to five substituents independently selected from the group consisting of R wherein said C wherein said C wherein said aryl is optionally substituted with up to three groups independently selected from OH and NH wherein said heteroaryl and said 5-heteroaryl, heterocycle, and said heterocycloalkyl, are each optionally substituted with up to three independently selected R wherein said C wherein any two adjacent carbon atoms of said aryl, heteroaryl or heterocycloalkyl can optionally be joined together by a group of the formula —O—C(Ra)(Rb)—O— wherein R except 4-((2-phenylaminophenylamino)methylene)-2-p-tolylisoquinoline-1,3(2H,4H)-dione, 4-[[(4-methoxyohenyl)amino]methylene]-2-(4-methylphenyl)-1,3(2H,4H)-isoquinolinedione, 2-(4-methoxyphenyl)-4-[[(4-methylphenyl)amino]]methylenel]-1,3(2H,4H)-isoquinolinedione, 2-(4-methoxyphenyl-4-[[(4-methoxyphenyl)amino]methylene]-1,3(2H,4H)-isoquinolinedione, 2-(4-chlorophenyl)-4-[[(4-nitrophenyl)amino]methylene]-1,3(2H,4H)-isoquinolinedione, 2-(4-chlorophenyl)-4-[[(4-methylphenyl)amino]methylene]-1,3(2H,4H)-isoquinolinedione, 2-phenyl-4-((p-tolylamino)methylene)isoquinoline-1,3(2H,4H)-dione, 6,7-dimethoxy-2-methyl-4-[(phenylamino)methylene]-1,3(2H,4H)-isoquinolinedione, 4-[(phenylamino)methylene]-2-(phenylmethyl)-1,3(2H,4H)-isoquinolinedione, 2-methyl-4-[(phenylamino)methylene]-1,3(2H,4H)-isoquinolinedione, 2-methyl-4-[(methylphenylamino)methylene]-1,3(2H,4H)-isoquinolinedione, 4-[(phenylamino)methylene]-1,3(2H,4H)-isoquinolinedione, 4-[[(4-chlorophenyl)amino]methylene]-1,3(2H,4H)-isoquinolinedione, 4-[[(4-chlorophenyl)amino]methylene]-2-methyl-1,3(2H,4H)-isoquinolinedione, 2-(4-methoxyphenyl)-4-[(phenylamino)methylene]-1,3(2H,4H)-isoquinolinedione, and 4-[bis(phenylamino)methylene]-2-methyl-1,3(2H,4H)-isoquinolinedione are excluded.