Patent ID: 6043374
Filing Date: 2000-03-28
Classification: C07D

Abstract:
A compound of the formula ##STR24## wherein R.sub.1 is independently selected from halogen, nitro, cyano, halosubstituted C.sub.10 alkyl, C.sub.10 alkyl, C.sub.2-10 alkenyl, C.sub.10 alkoxy, halosubstituted C.sub.10 alkoxy, azide, (CR.sub.8 R.sub.8)q S(O).sub.t R.sub.4, hydroxy, hydroxy C.sub.1-10 alkyl, aryl, arylC.sub.1-14 alkyl, aryloxy, aryl C.sub.1-4 alkyloxy, heteroaryl, heteroaryl C.sub.1-4 alkyl, heterocyclic, heterocyclic C.sub.1-4 alkyl, heteroaryl C.sub.1-4 alkyloxy, aryl C.sub.2-10 alkenyl, heteroaryl C.sub.2-10 alkenyl, heterocyclic C.sub.2-10 alkenyl, (CR.sub.8 R.sub.8)qNR.sub.4 R.sub.5, C.sub.2-10 alkenyl C(O)NR.sub.4 R.sub.5, (CR.sub.8 R.sub.8)q C(O)NR.sub.4 R.sub.5, (CR.sub.8 R.sub.8)q C(O)NR.sub.4 R.sub.10, S(O).sub.3 R.sub.8, (CR.sub.8 R.sub.8)q C(O)R.sub.11, C.sub.2-10 alkenyl C(O)R.sub.11, C.sub.2-10 alkenyl C(O)OR.sub.11, C(O)R.sub.11, (CR.sub.8 R.sub.8)q C(O)OR.sub.12, (CR.sub.8 R.sub.8)q OC(O)R.sub.11, (CR.sub.8 R.sub.8)q NR.sub.4 C(O)R.sub.11, (CR.sub.8 R.sub.8)qC(NR.sub.4)NR.sub.4 R.sub.5 ; (CR.sub.8 R.sub.8)q NR.sub.4 C(NR.sub.5)R.sub.11 ; (CR.sub.8 R.sub.8)q NHS(O).sub.2 R.sub.17, or (CR.sub.8 R.sub.8)q S(O).sub.2 NR.sub.4 R.sub.5, or two R.sub.1 moieties together may form O--(CH.sub.2).sub.S O-- or a 5 to 6 membered saturated or unsaturated ring; and wherein the aryl, heteroaryl and heterocyclic containing rings may all be optionally substituted;m is an integer having a value of 1 to 3;q is 0, or an integer having a value of 1 to 10;s is an integer having a value of 1 to 3;t is 0, or an integer having a value of 1 or 2;R.sub.4 and R.sub.5 are independently hydrogen, optionally substituted C.sub.1-4 alkyl, optionally substituted aryl, optionally substituted aryl C.sub.1-4 alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl C.sub.1-4 alkyl, heterocyclic, or heterocyclic C.sub.1-4 alkyl, or R.sub.4 and R.sub.5 together with the nitrogen to which they are attached form a 5 to 7 member ring which may optionally comprise an additional heteroatom selected from O/N/S;R.sub.8 is independently hydrogen or C.sub.1-4 alkyl;R.sub.10 is C.sub.10 alkyl C(O).sub.2 R.sub.8 ;R.sub.11 is hydrogen, C.sub.1-4 alkyl, optionally substituted aryl, optionally substituted aryl C.sub.1-4 alkyl, optionally substituted heteroaryl, optionally substituted heteroarylC.sub.1-4 alkyl, optionally substituted heterocyclic, or optionally substituted heterocyclicC.sub.1-4 alkyl;R.sub.12 is hydrogen, C.sub.10 alkyl, optionally substituted aryl, or optionally substituted arylalkyl;R.sub.17 is C.sub.1-4 alkyl, aryl, arylalkyl, heteroaryl, heteroarylC.sub.1-4 alkyl, heterocyclic, or heterocyclicC.sub.1-4 alkyl, and wherein the aryl, heteroaryl and heterocyclic rings may all be optionally substituted;provided that when m is 1, then R.sub.1 is not 5-nitro.