Patent ID: 9133023
Filing Date: 2015-09-15
Classification: B82Y,G01N

Abstract:
1. A nanopore sensor with a sub-nanometer-thick functional layer, comprising: a sensitive functional unit comprising: a substrate having a first opening extending through the substrate; and a sub-nanometer-thick functional layer disposed on the substrate, the sub-nanometer-thick functional layer having a nanopore extending through the sub-nanometer-thick functional layer, the sub-nanometer-thick functional layer made of an insulating material having a layered structure comprising boron nitride, graphene oxide, or hydrogenated graphene; and a micro-nanofluidic device comprising: a first micro-nanometer separation channel connected to a first side of the sensitive functional unit; a first fluidic reservoir connected to the first micro-nanometer separation channel; a first electrophoresis electrode or micropump connected to the first fluidic reservoir; a second micro-nanometer separation channel connected to a second side of the sensitive functional unit opposite to the first side; a second fluidic reservoir connected to the second micro-nanometer separation channel; a second electrophoresis electrode or micropump connected to the second fluidic reservoir; and a first electrode located in the first micro-nanometer separation channel and a second electrode located in the second micro-nanometer separation channel for measuring ionic current, the first micro-nanometer separation channel comprising a first micrometer dimension channel or a first nanometer dimension channel, the second micro-nanometer separation channel comprising a second micrometer dimension channel or a second nanometer dimension channel.