Patent ID: 8629113
Filing Date: 2014-01-14
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting T cell activation in the presence of B7-expressing antigen presenting cells (APCs) comprising contacting said T cells with an immunoadhesin, said immunoadhesin comprising a first domain comprising a variant CTLA4 as compared to SEQ ID NO:6 and a second domain comprising an IgG Fc region, wherein said variant CTLA4 comprises an amino acid modification selected from the group consisting of T51N, A29H, M53Y, L61E, and K93Q, wherein the binding of said variant CTLA4 to B7-1 (CD80) and/or B7-2 (CD86) is increased as compared to SEQ ID NO:6.