Patent ID: 6217901
Filing Date: 2001-04-17
Classification: A61K,Y10S

Abstract:
A method for synthesizing a synthetic polymer complement (SPC), the method comprising:a) mixing together in an aqueous solution a set of building blocks, lipid constituents and water-soluble target templates, at least some of the building blocks having moieties that are complementary to moieties on the target templates;b) forming a liposome, wherein the building blocks of the building block set are in the interior of the liposome and the target templates are in the lipid bilayer of the liposome, wherein the building blocks contact at least a portion of the target templates;c) polymerizing the building blocks of the building block set that are in the interior of the liposome; andd) removing the lipid bilayer of the liposome to give a SPC as a crosslinked three-dimensional polymeric network comprising surface regions that are capable of binding with high affinity to at least a portion of a target.