Patent ID: 7709647
Filing Date: 2010-05-04
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: (S)-N-[1-(3-Chlorobenzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-2-cyclohexyl-acetamide; (S)-N-(6-Cyano-1-thiazol-5-ylmethyl-1,2,3,4-tetrahydro-quinolin-3-yl)benzamide; (R)-N-(6-Cyano-1-thiazol-5-ylmethyl-1,2,3,4-tetrahydro-quinolin-3-yl)benzamide; (S)-N-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3 yl)-2-phenylacetamide; (S)-N-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; (S)-N-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-3-cyclohexyl-propionamide; N-(6-Cyano-1-phenethyl-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; (S)-N-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-2-morpholin-4-yl-acetamide; (R)-N-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-2-morpholin-4-yl-acetamide; N-(6-Cyano-1-cyclohexyl-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; N-(1-Benzyl-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; (S)-N-(1-Benzyl-6-bromo-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; (R)-N-(1-Benzyl-6-bromo-1,2,3,4-tetrahydroquinolin-3-yl)-2-cyclohexylacetamide; (S)-N-[1-(3-Chloro-benzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-2-phenylacetamide; (S)-N-(6-Cyano-1-pyridin-2-ylmethyl-1,2,3,4-tetrahydro-quinolin-3-yl)-2-phenyl acetamide; N-(1-benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-2-methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanamide; 3-(Benzo[d][1,3]dioxol-5-yl)-N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)propanamide; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-2-(benzyloxy)propanamide; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-2-(2-methoxyphenyl)acetamide; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-3-(3-methoxyphenyl)propanamide; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-2-(3,5-dimethoxyphenyl)acetamide; 3-(benzo[d][1,3]dioxol-5-yl)-N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)propanamide; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-2-(1,3-dioxoisoindolin-2-yl)propanamide; tert-butyl 2-((1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)carbamoyl)benzoate; N-(1-benzyl-6-chloro-1,2,3,4-tetrahydroquinolin-3-yl)-2-(1H-pyrrol-1-yl)benzamide; (2R)-N-(1-Benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-2-hydroxy-3-phenylpropanamide; (2S)-N-(1-Benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-2-hydroxy-3-phenylpropanamide; (2S)-N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-2-hydroxy-4-phenylbutanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-2-hydroxy-3-(1H-indol-2-yl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(2-methoxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(3-methoxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(4-methoxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(2-hydroxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(3-hydroxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-(4-hydroxyphenyl)propanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-3-phenylpropanamide; N-(1-benzyl-6-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-2-methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanamide; (S)-1-[1-(3-Chloro-benzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-3-cyclohexylurea; (S)-[1-(3-Chlorobenzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester; (S)-[1-(3-Chlorobenzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester; (R)-[1-(3-Chlorobenzyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester; (1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid cyclohexyl ester; (S)-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid cyclohexyl ester; (R)-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid cyclohexyl ester; (S)-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid benzyl ester; (R)-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid benzyl ester; (S)-(1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid tetrahydro-pyran-4-yl ester; (6-Cyano-1-phenethyl-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid cyclohexyl ester; (1-Benzyl-6-bromo-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid cyclohexyl ester; (1-Benzyl-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid 4-hydroxy-cyclohexyl ester; [1-Benzyl-6-(2H-tetrazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester; [1-Benzyl-6-(2-methyl-2H-tetrazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester; and [1-Benzyl-6-(1-methyl-1H-tetrazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-carbamic acid cyclohexyl ester.