Patent ID: 7399618
Filing Date: 2008-07-15
Classification: C12N,C12P

Abstract:
1. A method for producing L-histidine comprising: A) cultivating a bacterium in a culture medium, and B) collecting L-histidine from the culture medium, wherein the bacterium is of the Enterobacteriaceae family and has been modified to enhance transaldolase activity by increasing the copy number of the transaldolase gene or by replacing a promoter sequence of the transaldolase gene with a stronger promoter sequence, wherein said transaldoase gene comprises a DNA which is 90% or more homologous to nucleotides 1-954 of SEQ ID NO. 1 and encodes a protein which has transaldolase activity, and wherein said bacterium has been further modified to have enhanced expression of genes for L-histidine biosynthesis.