Patent ID: 9115384
Filing Date: 2015-08-25
Classification: C12Q,G01N,Y10S,Y10T

Abstract:
1. A composition for determining the activation profile of one or more cells, the composition comprising: a sample comprising one or more cells; a first activation state specific binding member specific for an isoform corresponding to an activation state of a first activatable element, wherein the first activatable element comprises a first activation state and a second activation state; and a second activation state specific binding member specific for an isoform corresponding to an activation state of a second activatable element, wherein the second activatable element comprises a first activation state and a second activation state, and wherein the first and the second activatable elements are different and are distinguishably detectable from one another; wherein the first and second activation state specific binding members detect binding to their corresponding activatable elements simultaneously or sequentially in single cells bound to their corresponding activatable element inside the one or more cells and said binding indicates the activation profile of each of the one or more cells in the sample.