Patent ID: 6291457
Filing Date: 2001-09-18
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR24##whereinX is C.sub.1 -C.sub.6 alkyl, said alkyl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 ; or a heterocyclic group connected to the imidazole ring by a direct bond or by C.sub.1 -C.sub.6 alkyl;R.sub.1 and R.sub.2 are independently hydrogen or C.sub.1 -C.sub.6 alkyl, said alkyl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 ; orR.sub.1 and R.sub.2 taken together with the nitrogen atom represent an optionally substituted 4 to 10 membered non-aromatic heterocyclic ring containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom; orR.sub.2 and X taken together represent an optionally substituted 4 to 10 membered non-aromatic heterocyclic ring containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atoms;Q is CH or N;R.sub.3 is hydrogen or NH(C.sub.1 -C.sub.6 alkyl)aryl;R.sub.4, R.sub.5 and R.sub.6 independently represent a member selected from the group consisting of hydrogen, halo, hydroxy, CF.sub.3, NH.sub.2, NO.sub.2, C.sub.1 -C.sub.6 alkyl, said alkyl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2, C.sub.1 -C.sub.6 alkoxy, said alkoxy group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 ; C.sub.3 -C.sub.8 cycloalkyl, said cycloalkyl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 or aryl, said aryl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 ;R.sub.7 is hydrogen or C.sub.1 -C.sub.6 alkyl, said alkyl group optionally substituted by 1-3 groups selected from halogen, hydroxy, CF.sub.3, NH.sub.2 and NO.sub.2 ;or a pharmaceutically acceptable addition salt and/or hydrate thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof.