Patent ID: 6258377
Filing Date: 2001-07-10
Classification: A61K,Y10S

Abstract:
A hydrophobic preparation comprising:(i) an oil phase comprising one or more medium chain monoglycerides and one or more medium chain diglycerides, said mono- and di-glycerides having chain lengths of 8 to 10 carbon atoms, said oil phase optionally comprising an additional compound selected from oleic acid, glycerol mono-oleate or a gelucire, wherein the monoglyceride(s) make(s) up 40-90% of the total amount of oil present;(ii) at least one amphiphile selected from the group consisting of phosphatidyl choline, phosphatidic acid, phosphatidyl glycerol, phosphatidyl ethanolamine, phosphatidyl serine or lyso derivatives thereof, octyl glucoside, tocopherol succinate, cholesterol hemisuccinate, sodium docusate, hydroxypropyl cellulose, and a bile salt, said bile salt being selected from the group of bile salts consisting of cholate, deoxycholate, chenodeoxycholate, ursodeoxycholate, taurocholate, taurodeoxycholate, tauroursodeoxycholate, taurochenodeoxycholate, glycholate, glycodeoxycholate, glycoursodeoxycholate, glycochenodeoxycholate, lithocholate, taurolithocholate and glycolithocholate; and(iii) a hydrophilic species solubilized or dispersed in the mixture of mono- and di-glycerides; wherein the hydrophilic species is not normally soluble in the mono- or di-glycerides and is selected from the group consisting of proteins, glycoproteins, nucleic acids analogues thereof and polysaccharides; said preparation containing no free water molecules.