Patent ID: 6462033
Filing Date: 2002-10-08
Classification: A61K

Abstract:
A method of preparing an aqueous suspension composition comprising ciprofloxacin, hydrocortisone, lecithin, and excipients selected from the group consisting of benzyl alcohol; acetate buffer, sodium chloride; surfactants and pH-adjusting agents, wherein the method comprisesa) dispersing hydrocortisone with lecithin and optionally a polysorbate surfactant in water for greater than 45 minutes to form a hydrocortisone slurry; b) preparing a ciprofloxacin composition separate from the hydrocortisone slurry, wherein the ciprofloxacin composition comprises ciprofloxacin, lecithin, and excipients selected from the group consisting of benzyl alcohol, acetate buffer, sodium chloride, surfactants and pH-adjusting agents; and c) combining the hydrocortisone slurry prepared in step a) with the ciprofloxacin composition prepared in step b).