Patent ID: 9080199
Filing Date: 2015-07-14
Classification: C12N,C12P,C12Q,C12R

Abstract:
1. A method for identifying a bioactive compound in a culture comprising: (i) co-culturing two or more organisms, wherein at least one organism is a parent producer organism and at least one other organism is a target and wherein the parent producer organism is (ii) detecting inhibition of growth of the target organism(s); (iii) isolating from the co-culture the parent producer organism after the detecting of OD; (iv) repeating (i)-(iii) at least once with the isolated producer and the target to produce an evolved strain of the parent producer, wherein the evolved strain may or may not produce holomycin; and (v) detecting the presence of one or more bioactive compounds in the co-culture in addition to or other than holomycin, thereby identifying a bioactive compound produced by the evolved producer organism.