Patent ID: 8961783
Filing Date: 2015-02-24
Classification: B01D,G01N

Abstract:
1. A liquid-chromatography apparatus, comprising: at least two solvent reservoirs respectively containing a first solvent and a second solvent, which each contain dissolved gas; a gradient proportioning valve in fluid communication with the at least two solvent reservoirs; a pump comprising at least two pistons disposed in respective chambers in parallel or serial fluid communication with an outlet of the gradient proportioning valve to receive a flow of proportioned solvents from the gradient proportioning valve; at least one bubble-dispersing unit in fluid communication with the pump to receive a pressurized flow of proportioned solvents from the pump and to disperse bubbles in the flow; and a control unit, in communication with the pump and the gradient proportioning valve, and comprising at least one processor and at least one memory for storing a plurality of instructions, which, when executed by the at least one processor, causes implementation of the steps of, repeatedly switching the gradient proportioning valve to provide the proportioned solvents in association with a preselected solvent composition, and drawing the selected solvent mixture into the pump at a flow rate of at least 5 ml/min.