Patent ID: 6033862
Filing Date: 2000-03-07
Classification: G01N,Y10S

Abstract:
A method for diagnosing or evaluating dialysis-related amyloidosis in a dialysis patient comprising:obtaining a sample of blood from the patient and lysing at least a portion of blood cells from the sample to provide a specimen of hemoglobin;reacting the hemoglobin specimen with an isolated antibody specific for an epitope comprising a carboxymethylated amino acid residue under conditions sufficient for antibody binding to any of said epitope present in hemoglobin in the specimen;detecting a level of binding of the antibody to the hemoglobin wherein the binding level is indicative of carboxymethylated hemoglobin level in the specimen and said carboxymethylated hemoglobin level is used in diagnosing or evaluating dialysis-related amyloidosis in the dialysis patient.