Patent ID: 6140317
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR14## wherein R.sub.1 and R.sub.2 are each independently of the other lower alkyl; monohalo-, dihalo- or trihalo-lower alkyl; lower alkoxy; phenyl that is unsubstituted or substituted by halogen, monohalo-, dihalo- or trihalo-lower alkyl, carbamoyl-methoxy, carboxy-methoxy, benzyloxycarbonyl-methoxy, lower alkoxycarbonyl-methoxy, phenyl, amino, amino-lower alkyl, lower alkanoylamino, lower alkoxycarbonylamino, phenyl-lower alkoxycarbonylamino, furoyl, thienylcarbonyl, N-lower alkylamino, N,N-di-lower alkylamino, hydroxy, lower alkoxy, lower alkanoyloxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, cyano, amidino, N-(N',N'-di-lower alkylaminomethylidene)-amino, N-((N',N'-di-lower alkylamino)-(lower alkyl)-methylidene)-amino, guanidino, ureido, N.sup.3 -lower alkylureido, N.sup.3,N.sup.3 -di-lower alkylureido, thioureido, N.sup.3 -lower alkylthioureido, N.sup.3,N.sup.3 -di-lower alkylthioureido, lower alkanesulfonylamino, benzene- or naphthalene-sulfonylamino that is unsubstituted or lower alkyl-substituted at the benzene or naphthalene ring, azido or by nitro; hydrogen; unsubstituted or halo- or lower alkyl-substituted pyridyl; N-benzyl-pyridonyl; naphthyl; cyano; carboxy; lower alkoxycarbonyl; carbamoyl; N-lower alkyl-carbamoyl; N,N-di-lower alkyl-carbamoyl; N-benzyl-carbamoyl; formyl; lower alkanoyl; lower alkenyl; lower alkenyloxy; or lower alkyl substituted by amino, lower alkylamino, piperazino, di-lower alkylamino, phenylamino or phenyl (each unsubstituted or substituted in the phenyl moiety by halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkyl-carbamoyl, cyano, amidino, amino, amino-lower alkyl, lower alkanoylamino, lower alkylamino, N,N-di-lower alkylamino or by trifluoromethyl), hydroxy, lower alkoxy, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkyl-carbamoyl, N,N-di-lower alkyl-carbamoyl, mercapto or by a radical of the formula R.sub.5 --S(O.sub.q)-- wherein R.sub.5 is lower alkyl and q is 0, 1 or 2, andQ is a radical selected from the group consisting of 2,3-dihydroindol-1-yl,1,2,3,4-tetrahydroquinolin-1-yl, 2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl, 1,2,3,4,5,6-hexahydrobenzo[b]azocin-1-yl, 2,3,6,7,8,9-hexahydro-1H-benzo[g]indol-1-yl, 1,2,3,5-tetrahydropyrrolo[2,3-f]indol-1-yl and 1,2,3,5,6,7-hexahydro-pyrrolo[2,3-f]indol-1-yl; each of the mentioned radicals being unsubstituted or substituted by from 1 to 3 radicals selected independently of one another from the group consisting of lower alkyl, N,N-di-lower alkylamino-lower alkyl, lower alkynyl, tri-lower alkylsilanyl-lower alkynyl, halogen, nitro, hydroxy, lower alkoxy, isothiocyanato, unsubstituted phenyl, unsubstituted phenyl-lower alkoxy, carboxy, lower alkoxycarbonyl, amino, azido, lower alkanoylamino, trihalo-lower alkylcarbonylamino, pyrrol-1-yl and pyrrolidin-1-yl or substituted by lower alkylenedioxy that is formed by two radicals together and is bonded to two vicinal ring atoms;or a salt thereof where at least one salt-forming group is present.