Patent ID: 6066662
Filing Date: 2000-05-23
Classification: A61P,C07C,C07D

Abstract:
A compounds of the formula ##STR11## wherein A represents a group of the formula ##STR12## R.sup.1 represents cyclopropyl, cyclobutyl or cyclopentyl; R.sup.2 represents hydrogen, or a group of the formula --(CH.sub.2).sub.n -aryl, --(CH.sub.2).sub.n -Het in which n stands for 1-4 and Het represents a 5- or 6-membered N-heterocyclic ring which (a) is attached via the N atom, (b) optionally contains N, O and/or S as additional hetero atom(s) in a position or positions other than adjacent to the linking N atom, (c) is substituted by oxo on one or both C atoms adjacent to the linking N atom and (d) is optionally benz-fused or optionally substituted on one or more other carbon atoms by lower alkyl or oxo and/or on any additional N atom(s) by lower alkyl or aryl; andR.sup.3 represents hydrogen or lower alkyl optionally substituted by aryl, amino, protected amino, di(lower alkyl)amino, guanidino, carboxyl, protected carboxyl, carbamoyl, pyrrolidino, piperidino or morpholino;and pharmaceutically acceptable salts thereof.