Patent ID: 7872095
Filing Date: 2011-01-18
Classification: A61K,A61P,C07K

Abstract:
1. An insulin compound coupled to a modifying moiety having a formula: where, X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond, wherein X, Y, and Z may be independently selected from —C(O)—, —O—, —S—, and —N—, at least one of R PAG is a linear or branched carbon chain incorporating one or more alkylene glycol moiety wherein the alkylene glycol moiety is a substantially monodispersed PEG molecule having has a formula (CH where the modifying moiety has a maximum number of 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 heavy atoms, wherein the heavy atoms comprises one or more carbon atoms and one or more non-carbon heavy atoms selected from the group consisting of —O—, —S—, —N—, and ═O; wherein the insulin is mammalian or an insulin analog thereof and wherein the modifying moiety is coupled to a lysine within 5 amino acids of the C-terminus of the B chain of the mammalian insulin or insulin analog and wherein the lysine is at a position selected from the group consisting of position B26, B27, B28, B29 and B30 of insulin thereby providing a monoconjugate.