Patent ID: 9157098
Filing Date: 2015-10-13
Classification: A61K,C07K,C12N

Abstract:
1. A composition, comprising: a recombinant adeno-associated viral (rAAV) particle that comprises a modified capsid protein, wherein the modified capsid protein comprises at least a first non-tyrosine amino acid at a position that corresponds to a surface-exposed tyrosine residue selected from the group consisting of Tyr252, Tyr272, Tyr275, Tyr281, Tyr508, Tyr612, Tyr704, Tyr720, Tyr730, and Tyr673 in a wild-type AAV2 capsid protein; wherein the transduction efficiency of the rAAV particle comprising the modified capsid protein is higher than that of a rAAV particle comprising a corresponding, unmodified AAV capsid protein.