Patent ID: 6153755
Filing Date: 2000-11-28
Classification: C07D

Abstract:
A process for preparation of a 4-aryl-3-hydroxymethyl-piperidine of structure (1) ##STR6## in which R is hydrogen, alkyl, arylalkyl, allyl, carbonyloxyalkyl, carbonyloxyaryl, or carbonyloxyalkylaryl, and X is one or more of hydrogen, halogen, hydroxy, alkoxy, nitro, nitrile, amino (optionally protected or substituted), trifluoromethyl, acyl, formyl, carboxyl or carboxyalkyl, which comprises reducing an isoxazolidine of structure (2) ##STR7## or a compound of structure (4) ##STR8## in which R and X are as defined above, and R' is independently selected from the same groups as R or is a chiral auxiliary.