Patent ID: 6239125
Filing Date: 2001-05-29
Classification: A61K,A61P,C07D

Abstract:
A compound of formula 1 selected from the group consisting of: ##STR26##wherein R.sub.1, Y, R.sub.12 and R.sub.13 are as defined below:Entry No. R.sub.1 Y 101 CH.sub.2 --(S)CH(CH.sub.2 CHMe.sub.2)--NH-Tbg-Boc S 102 Ph S 103 CH.sub.2 Ph S 104 CH.sub.2 CH.sub.2 Ph S 105 CH.sub.2 --(S)CH(CH.sub.2 CH.sub.2 SO.sub.2 Me)--NH-Tbg-Boc S 106 CH.sub.2 --(S)CH(CH.sub.2 CH.sub.2 SO.sub.2 Me)--NH-Tbg-Boc S 107 Ph SO 108 Ph SO 109 4-pyridinylmethyl S 110 3-pyridinylmethyl S 111 2-pyridinylmethyl S 112 CH.sub.2 COPh S 113 2-pyridinylmethyl S 114 2-pyridinylmethyl S 115 CH.sub.2 --(S)CH(CH.sub.2 CHMe.sub.2)--NH-Tbg-COCH.sub.2 CMe.sub.3 S 116 2-pyridinylmethyl S Entry No. R.sub.12 R.sub.13 *(R) or (S) 101 Ph H S 102 Ph Me S 103 Ph Me S 104 Ph Me S 105 Ph Me S 106 Ph Me R 107 Ph Me R 108 Ph Me S 109 Ph Me S 110 Ph Me S 111 Ph Me S 112 Ph Me S 113 CH.sub.2 CH.sub.2 OBn H S 114 Ph Et S 115 Ph Et S 116 Ph CH.sub.2 OH Sor a therapeutically acceptable acid addition salt thereof,wherein Tbg is tert-butylglycine, Me is methyl, Et is ethyl, Bn is benzyl, Ph is phenyl and Boc is tert-butyloxycarbonyl.