Patent ID: 6355669
Filing Date: 2002-03-12
Classification: A61K

Abstract:
A method of treating nephritis or lupus nephritis comprising administering to a subject in need of same an effective a compound of the following formula or a pharmacologically acceptable salt thereof or a hydrate of the salt: where R1, R2, R3, R4 and R8 each represents hydrogen, halogeno, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted lower alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted cycloalkylalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkyloxy, optionally substituted cycloalkylalkyloxy, optionally substituted arylalkyloxy, optionally substituted heteroarylalkyloxy, optionally substituted alkenyl or optionally substituted alkynyl, or alternatively two of R1, R2, R3, R4 and R8 adjacent to each other together with the carbon atoms to which they are bonded respectively may form a ring which may contain a heteroatom or be substituted; A represents an optionally substituted pyrrole ring, B represents an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D represents an optionally protected carboxyl.