Patent ID: 6306857
Filing Date: 2001-10-23
Classification: A61K,A61P

Abstract:
A method of inhibiting the formation of abnormally phosphorylated paired helical filament epitopes associated with Alzheimer's Disease comprising administering to a patient in need thereof an amount of a compound effective to inhibit the formation of the abnormally phosphorylated epitopes, where the compound is:(a) 1-(p-Iodophenyl)-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride;(b) 1-(p-Fluorophenyl)-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride;(c) 1-(o-Fluorophenyl)-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride;(d) 1-(p-Iodophenyl)-3-[4'-(o-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(e) 1-(o-Fluorophenyl)-3-[4'-(o-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(f) 1-(o-Fluorophenyl)-3-[4'-(p-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(g) 1-(p-Fluorophenyl)-3-[4'-(p-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(h) 1-(m-Fluorophenyl)-3-[4'-(p-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(i) 1-(p-Iodophenyl)-3-[4'-(p-fluorobenzyl)-1'-piperazinyl]-1-propanone dihydrochloride;(j) 1-(6""-Fluoro-2""-methylphenyl)-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride;(k) 1-(m-Fluorophenyl)-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride; and(l) 1-o-Iodophenyl-3-(4'-benzyl-1'-piperazinyl)-1-propanone dihydrochloride.