Patent ID: 8183263
Filing Date: 2012-05-22
Classification: A61P,C07D

Abstract:
1. A compound of Formula I or Formula II, or pharmaceutically acceptable salt, wherein: A is a monocyclic or bicyclic group of the formula: where Q is O, S, N, CH R represents 0 or 1 or more substituents independently chosen from (a) hydroxyl, halogen, amino, cyano, —COOH, —CONH (b) C any two R groups, covalently bound to adjacent atoms, may be joined to form a 5-membered heterocyclic group containing 1 or 2 additional heteroatoms independently chosen from N, O, and S, wherein the 5-membered heterocyclic group is optionally substituted with an oxo group; R R and R R R R R (i) R R (ii) R R (iii) one of R the other of R (iv) one of R the other of R (v) one of R (vi) one of R (vii) R wherein the compound is not: N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; 4-(6-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine; N-(3-fluoro-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-((piperidin-1-yl)methyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-(2,3-dihydro-1H-inden-2-yloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine; 5-(4-(pyridin-3-yl)thiazol-2-ylamino)-2-(heptyloxy)benzonitrile; N-(3-methyl-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-butoxy-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-pentylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-(benzyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-phenoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-(phenethyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-(hexyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-butoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-(heptyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-hexylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-octylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-butylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-benzylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; 2-(4-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)acetonitrile; N1-isopropyl-N1-phenyl-N4-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,4-diamine; butyl 4-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate; ethyl 2-(4-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)acetate; N-(4-propylphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(4-phenoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine; N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine; N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine; and N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-N-methyl-4-(pyridin-3-yl)thiazol-2-amine.