Patent ID: 8647645
Filing Date: 2014-02-11
Classification: A61K,A61P

Abstract:
1. An orally-ingestible substrate coated with an aqueous suspension formed by mixing a dry powder composition comprising a) polyvinyl alcohol, b) a polymer with pH dependent solubility selected from the group consisting of methacrylic acid copolymers, cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, poly(butyl methacrylate, 2-dimethylaminoethyl methacrylate, methyl methacrylate) 1:2:1 and combinations thereof, c) an alkalizing agent comprising sodium bicarbonate present in an amount up to about 6% by weight, calculated based upon the amount of polymer with pH dependent solubility, d) about 12 to about 40% by weight of a glidant and e) optionally a plasticizer; with water wherein the aqueous suspension is applied to the orally-ingestible substrate as a single coating layer, and the coated orally-ingestible substrate disintegrates in an aqueous medium of pH 1.2 in less than 30 minutes.