Patent ID: 7671046
Filing Date: 2010-03-02
Classification: A61K,A61P,C07F

Abstract:
1. A method for inhibiting Src-c, Abl, ZAP-70, or RSK1 protein kinase activity in a subject having cancer comprising administering to said subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt or ester thereof, wherein: X R and/or R R Ar is a mono-, bi-, or tricyclic, carbo- or heterocyclic ring, wherein the ring is either unsubstituted or substituted in one or more position(s) with halo, hydroxyl, nitro, trifluoromethyl, C M is Ru, Pt, Tc, Re, Os, Rh, Ir, Pd, Au, Cu, Fe, Co, or Cr; A and A′ are each independently hydrogen, hydroxy, hydroxymethyl, C A and A′ are taken together as ═O; and each L L L L n is 2, 3, 4, or 5; at least one pair of R