Patent ID: 6083951
Filing Date: 2000-07-04
Classification: A61P,C07D

Abstract:
A compound having the formula VII; wherein:Q is a naphthyl or biphenyl group which is either unsubstituted or is substituted at one, two, or three positions with A.sup.1 ;A.sup.1 and R.sup.2 are independently selected at each occurrence from hydrogen, C.sub.1 -C.sub.6 -alkoxy, di-halogeno-C.sub.1 -C.sub.6 -alkoxy, tri-halogeno-C.sub.1 -C.sub.6 -alkoxy, phenyl, phenoxy, phenyl-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkyl, amino-C.sub.1 -C.sub.6 -alkyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, N-[C.sub.1 -C.sub.4 -alkyl]amino-C.sub.1 -C.sub.6 -alkyl, N,N-[di-C.sub.1 -C.sub.4 -alkyl]amino-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, halogeno-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylthio-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylsulphonyl-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylsulphonyl-C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.8 -cycloalkyl-C.sub.1 -C.sub.6 -alkyl, phenyl-C.sub.1 -C.sub.6 -alkyl, halogeno, hydroxy, mercapto, cyano, nitro, carboxy, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.2 -C.sub.6 -alkenyloxycarbonyl, phenyloxycarbonyl, phenyl-C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.6 -alkanoyl, benzoyl, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphinyl, C.sub.1 -C.sub.6 -alkylsulphonyl, phenylthio, phenylsulphinyl, phenylsulphonyl, C.sub.1 -C.sub.6 -alkanoylamino, trifluoroacetyl, trifluoroacetamido, N-[C.sub.1 -C.sub.4 -alkyl]trifluoroacetamido, benzamido, N-[C.sub.1 -C.sub.4 -alkyl]benzamido, carbamoyl, C.sub.1 -C.sub.4 -alkylcarbamoyl, di-C.sub.1 -C.sub.4 -alkylcarbamoyl, phenylcarbamoyl, sulphamoyl, N-C.sub.1 -C.sub.4 -alkylsulphamoyl, N,N-di-C.sub.1 -C.sub.4 -alkylsulphamoyl, N-phenylsulphamoyl, C.sub.1 -C.sub.6 -alkanesulphonamido, benezenesulphonamido, ureido, 3-C.sub.1 -C.sub.6 -alkylureido, 3-phenylureido, thioureido, 3-C.sub.1 -C.sub.6 -alkylthioureido and 3-phenylthioureido; orA.sup.1 and R.sup.2 independently are a group --NRaRb, in which Ra and Rb are independently selected from hydrogen, C.sub.1 -C.sub.6 -alkyl, phenyl-C.sub.1 -C.sub.4 -alkyl and C.sub.1 -C.sub.6 -alkyl bearing a carboxy or C.sub.1 -C.sub.4 -alkoxycarbonyl group; orA.sup.1 and R.sup.2 independently are a group --NRaRb in which Ra and Rb taken together complete a 1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 1-piperidinyl or 2-oxo-1-piperidinyl ring;R.sup.1 is selected from 2-[C.sub.1 -C.sub.6 -alkoxycarbonyl]ethenyl, 2-phenylethenyl, C.sub.2 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkoxycarbonylethynyl, phenylethynyl, C.sub.1 -C.sub.3 -alkoxy, dihalogeno-C.sub.1 -C.sub.3 -alkoxy, trihalogeno-C.sub.1 -C.sub.3 -alkoxy, phenyl-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.6 -alkyl, amino-C.sub.1 -C.sub.6 -alkyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, N-[C.sub.1 -C.sub.4 -alkyl]amino-C.sub.1 -C.sub.6 -alkyl, N,N-[di-C.sub.1 -C.sub.6 -alkyl]amino-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, halogeno-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylthio-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylsulphinyl-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkylsulphonyl-C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.8 -cycloalkyl-C.sub.1 -C.sub.6 -alkyl, phenyl-C.sub.1 -C.sub.6 -alkyl, halogeno, hydroxy, mercapto, cyano, nitro, carboxy, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.2 -C.sub.6 -alkenyloxycarbonyl, phenyloxycarbonyl, phenyl-C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.6 -alkanoyl, benzoyl, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphinyl, C.sub.1 -C.sub.6 -alkylsulphonyl, phenylthio, phenylsulphinyl, phenylsulphonyl, C.sub.1 -C.sub.6 -alkanoylamino, trifluoroacetyl, trifluoroacetamido, N-[C.sub.1 -C.sub.4 -alkyl]trifluoroacetamido, benzaamido, N-[C.sub.1 -C.sub.4 -alkyl]benzamido, carbamoyl, C.sub.1 -C.sub.4 -alkylcarbamoyl, di-C.sub.1 -C.sub.4 -alkylcarbamoyl, phenylcarbamoyl, sulphamoyl, N-C.sub.1 -C.sub.4 -alkylsulphamoyl, N,N-di-C.sub.1 -C.sub.4 -alkylsulphamoyl, N-phenylsulphamoyl, C.sub.1 -C.sub.6 -alkanesulphonamido, benezenesulphonamido, ureido, 3-C.sub.1 -C.sub.6 -alkylureido, 3-phenylureido, thioureido, 3-C.sub.1 -C.sub.6 -alkylthioureido and 3-phenylthioureido; orR.sup.1 is a group --NRaRb, in which Ra and Rb are independently selected from hydrogen, C.sub.1 -C.sub.6 -alkyl, phenyl-C.sub.1 -C.sub.4 -alkyl and C.sub.1 -C.sub.6 -alkyl bearing a carboxy or C.sub.1 -C.sub.4 -alkoxycarbonyl group; orR.sup.1 is the group --NRaRb in which Ra and Rb taken together complete a 1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 1-piperidinyl or 2-oxo-1-piperidinyl ring;where any phenyl, naphthyl or benzene moiety of A.sup.1, R.sup.1 or R.sup.2 is either unsubstituted or is substituted at one or two positions, with substituents independently selected at each occurrence from C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, halogeno, cyano and trifluoromethyl; ora pharmaceutically-acceptable salt of any foregoing compound.