Patent ID: 9181341
Filing Date: 2015-11-10
Classification: A61K,A61P,C07K

Abstract:
1. A method of producing an antibody suitable for use as a medicament in the treatment of a disorder characterized by pathogenic killer immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2)-expressing cells, said method comprising: i) producing an antibody that specifically binds to a KIR3DL2 and comprises an Fc region that is an IgG4 isotype or an IgG isotype modified to decrease binding to Fc receptors, ii) contacting the antibody with proliferating KIR3DL2-expressing CD4+ T cells and measuring the ability of the antibody to inhibit proliferation of KIR3DL2-expressing CD4+ T cells, said measuring being carried out in the absence of immune effector cells; and iii) selecting an antibody that inhibits proliferation of KIR3DL2-expressing CD4+ T cells for use as a medicament and/or in the manufacture of a medicament.