Patent ID: 6380205
Filing Date: 2002-04-30
Classification: A61P,C07D

Abstract:
A compound having the formula: or a pharmaceutically acceptable salt thereof, whereinR1 is 2-quinazoline; optionally substituted with fluoro, amino, or hydroxy; R2 is phenyl, optionally substituted with one to five substituents, each substituent independently being chloro, fluoro, bromo, C1-C4alkyl, trifluoromethyl, hydroxy, or carboxy; L1 and L2 are independently C1-C4alkyl, C1-C4 alkenyl, C1-C4alkynyl, C1-C4alkoxy, amino, aminoC1-C4alkyl, hydroxyC1-C4alkyl, carbonyl, cycloC3-C6alkyl or aminocarbonyl; A1, A2, and A3 are each hydrogen or i) A1 and A2 form a two carbon bridge or ii) A1 and A3 form a two carbon bridge; and optionally substituted with X, wherein X is hydroxy, amino, C1-C4alkylamino, di(C1-C4)alkylamino, C1-C4alkyl or carbamate.