Patent ID: 6723570
Filing Date: 2004-04-20
Classification: A61K,C07K

Abstract:
A method of detecting expression of mammalian CC-chemokine receptor 1 (CCR1) or portion thereof comprising the second extracellular loop by a cell or fraction of said cell, comprising:a) contacting a composition comprising a cell or fraction of said cell to be tested with an antibody or antigen-binding fragment thereof which binds to mammalian CC-chemokine receptor 1 (CCR1) or portion of said receptor comprising the second extracellular loop, wherein said antibody or antigen-binding fragment thereof binds the second extracellular loop of said receptor, under conditions appropriate for binding of said antibody or antigen-binding fragment thereof to a mammalian CCR1 or portion thereof comprising the second extracellular loop; and b) detecting binding of said antibody or antigen-binding fragment thereof, wherein the binding of said antibody or antigen-binding fragment thereof indicates the presence of said receptor or portion of said receptor comprising the second extracellular loop on said cell or said fraction of said cell.