Patent ID: 6060480
Filing Date: 2000-05-09
Classification: C07D,Y10S

Abstract:
A method for the prophylaxis or treatment of muscle tissue degeneration, comprising administering to a patient in need of same an effective amount of the quinoline compound of the formula (I): ##STR4## wherein, in the formula (I), R.sup.1 to R.sup.8 mean the following: R.sup.1 : lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl, alkenyl, alkoxyl, alkoxy(lower)alkyl or alkylthio,R.sup.2, R.sup.3 : may be the same or different and each is independently hydrogen atom, halogen atom, lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl, alkenyl, alkoxyl, C.sub.m F.sub.2m+1 --, --(CH.sub.2).sub.n R.sup.9 or --(CH.sub.2).sub.p COR.sup.10,R.sup.4 : hydrogen atom, halogen atom, lower alkyl, alkoxyl or C.sub.m F.sub.2m+1 --,R.sup.5 : hydrogen atom, halogen atom, --COOH, -COOR.sup.11, --CONH.sub.2 or --CN,R.sup.6 : --COOH, --COOR.sup.12, --CONH.sub.2, --CN, --NHSO.sub.2 CF.sub.3 or C-bound tetrazolyl,R.sup.7, R.sup.8 : may be the same or different and each is independently hydrogen atom, halogen atom, lower alkyl, alkoxyl or C.sub.m F.sub.2m+1 --, andX, Y: may be the same or different and each is independently CH or nitrogen atom,wherein, R.sup.9 -R.sup.12, m, n and p above mean the following:R.sup.9 : hydroxyl or alkoxyl,R.sup.10 : hydrogen atom, hydroxyl, lower alkyl or alkoxyl,R.sup.11, R.sup.12 : may be the same or different and each is independently lower alkyl, alkenyl, cyclo(lower)alkyl, aryl or aralkyl,m: an integer of 1 to 6,n: an integer of 1 to 4, andp: an integer of 0 to 4,or a pharmaceutically acceptable salt thereof, to a patient.