Patent ID: 6194426
Filing Date: 2001-02-27
Classification: A61K,A61P,C07D

Abstract:
A pyrrole derivative having the formula (I): ##STR16##in whichHet denotes a ring condensed with pyrrole to form a 5,6,7,8-tetrahydroindolizine ring, Het' is a pyridyl or pyridyl N-oxide radical; R.sub.2 is a hydrogen or halogen atom or an alkyl, alkenyl, trihalomethyl or cyano radical, R.sub.3 is a hydrogen or halogen atom or a hydroxyl or alkyl radical, and R.sub.1 is alkoxycarbonyl, acyl containing 1, 3 or 4 carbon atoms or imidazolyl carbonyl; orHet denotes a ring condensed with pyrrole to form a 5,6,7,8-tetrahydroindolizine ring, Het' is a pyridyl or pyridyl N-oxide radical, R.sub.1 is a carboxamide, cyano, carboxyl, alkoxycarbonyl, acyl or imidazolylcarbonyl radical, R.sub.3 is a hydrogen or halogen atom or a hydroxyl or alkyl radical, and R.sub.2 is alkenyl, trihalomethyl or cyano; orHet denotes a ring condensed with pyrrole to form a 5,6,7,8-tetrahydroindolizine ring, R.sub.1 is a carboxamide, cyano, carboxyl, alkoxycarbonyl, acyl or imidazolylcarbonyl radical, R.sub.2 is a halogen atom or an alkyl, alkenyl, trihalomethyl or cyano radical, R.sub.3 is a hydrogen or halogen atom or a hydroxyl or alkyl radical, and Het' is 4-pyridyl or 2-pyridyl; orHet denotes a ring condensed with pyrrole to form a 5,6,7,8-tetrahydroindolizine ring, R.sub.1 is a carboxamide, cyano, carboxyl, alkoxycarbonyl, acyl or imidazolylcarbonyl radical, R.sub.2 is a hydrogen or halogen atom or an alkyl, alkenyl, trihalomethyl or cyano radical, and R.sub.3 is halogen or hydroxyl, and Het' is 3-pyridyl,or a pharmaceutically acceptable salt thereof.