Patent ID: 7301023
Filing Date: 2007-11-27
Classification: A61P,C07B,C07D

Abstract:
1. A method for resolving enantiomers of a compound containing the structure of the formula: pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable base addition salts thereof and free base thereof; wherein y is 0, 1 or 2; R R  wherein a is 0, 1, 2, 3 or 4; b, c, e, f and g are each independently 0 or 1; d is 0, 1, 2, or 3; X is S(O) Y is S(O) Z is carbonyl, C(O)O—, C(O)NR— or S(O) R R said method comprising the steps of: a) mixing a racemic mixture of enantiomers of a compound, cantaining the structure of said formula; in a solvent, with a resolving compound having a defined stereospecificity, to orm a solution and with said resolving agent being capable of binding with at least one but not all of said enantiomers to form a precipitate, containing said at least one of said enantiomers, b) allowing the mixture to stand for a time sufficient to allow substantial precipitation of a stereospecific enantiomer of the racemic mixture from the solution and wherein another of said enantiomers remains in said solution; and c) depending on the stereospecific enantiomer of the compound which is desired, collecting either the precipitate and purifying it or collecting the solution with contained other of said enantiomers and recrystallizing the enantiomer contained in said solution.