Patent ID: 9132179
Filing Date: 2015-09-15
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. An isolated detoxified pneumococcal neuraminidase wherein the detoxified pneumococcal neuraminidase comprises an amino acid sequence of a non-detoxified neuraminidase A (NanA) (SEQ ID NO: 15 or SEQ ID NO: 16) with at least one amino acid substitution, wherein the amino acid sequence of the detoxified pneumococcal neuraminidase is at least 80% identical to the non-detoxified neuraminidase, and wherein the detoxified pneumococcal neuraminidase has reduced activity as compared to the non-detoxified neuraminidase and wherein the detoxified pneumococcal neuraminidase is antigenic.