Patent ID: 7833549
Filing Date: 2010-11-16
Classification: A61K,A61P

Abstract:
1. A composition for the nasal administration of an antihistamine in a dry powder form suitable for administration of said antihistamine to the nasal region, the dry powder form made by a process comprising the following steps: providing preformed diketopiperazine microparticles between 10 and 20 microns in diameter; suspending said diketopiperazine microparticles in an aqueous medium with an antihistamine to form a suspension; and forming antihistamine-coated diketopiperazine microparticles by removing solvent from said suspension; wherein said antihistamine-coated diketopiperazine microparticles are between about 10 microns and about 20 microns in diameter, more than 50% of the microparticles have a particle size greater than about 10 microns, and wherein the particles are maximally retained in the nasal cavity and the composition does not pass into the pulmonary system.