Patent ID: 8748112
Filing Date: 2014-06-10
Classification: A61K,A61P,C07K

Abstract:
1. A method of determining whether a cancer cell is responsive to treatment by a Notch pathway inhibitory agent wherein the inhibitory agent is a fusion protein comprising a negative regulator of Notch signaling and an Antennapedia homeodomain, the method comprising, (i) administering said Notch inhibitory agent to a cancer cell that has an increased level of Notch 1 as compared to a normal cell and (ii) measuring the level of Notch 1, wherein a lower level of Notch 1 in the cancer cell treated with the Notch inhibitory agent as compared with the level of Notch 1 in a cancer cell not treated with the Notch inhibitory agent is indicative of a cancer cell responsive to treatment by a Notch pathway inhibitory agent.