Patent ID: 6664253
Filing Date: 2003-12-16
Classification: A61P,C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt thereof,whereinR1 denotes C1-C6-alkyl or Ar2, R2 denotes hydrogen, C1-C6-alkyl or C3-C6-cycloalkylmethyl, or R1 and R2 taken together denote a C2-C3-alkylenediyl group optionally substituted by one or two oxo groups, X denotes O or NR5, Ar1 and Ar2 independently of one another denote unsubstituted phenyl or phenyl which is 1- to 5-substituted by halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, C1-C4-fluoroalkoxy or â€”OCH2Oâ€”; R3 denotes 2-phenyl-ethyl, wherein the phenyl group may be substituted by 1 to 3 substituents, wherein the substituents, independently of one another, are selected from halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, and C1-C4-fluoroalkoxy; denotes hydrogen, C1-C4-alkyl, C3-C8-cycloalkyl, CH2COOH, â€”CH2C(O)NH2, â€”OH or phenyl-C1-C4-alkyl; and R5 denotes hydrogen or C1-C6-alkyl.