Patent ID: 6252079
Filing Date: 2001-06-26
Classification: A61P,C07D,C07F,Y02P

Abstract:
A method of synthesizing compounds having the formula ##STR16##via a 4+1 radical annulation/cyclization wherein the precursor ##STR17##is reacted with an aryl isonitrile having the formula ##STR18##wherein X is Br or I, and R.sup.4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R.sup.16 is H, a C.sub.1 -C.sub.6 alkoxy group, a ##STR19##group wherein p is an integer between 4 and 12, or a C.sub.1 -C.sub.12 dialkylamino group.