Patent ID: 7795426
Filing Date: 2010-09-14
Classification: C07D

Abstract:
1. A process for the preparation of a compound of formula (II) or an enantiomer, diastereomer, hydrate, or pharmaceutically acceptable salt, ester or amide thereof; wherein p is an integer selected from 1 or 2; R q is an integer selected from 0, 1 or 2; each R R each R R R alternatively, R each R comprising reacting a compound of formula (XX); in a first organic solvent; to yield the corresponding compound of formula (XXI), wherein L is a leaving group; and wherein the compound of formula (XXI) is not isolated; reacting the compound of formula (XXI) with a compound of formula (XXII); in the presence of an organic or inorganic base; in a second organic solvent; to yield the corresponding compound of formula (XXIII); wherein the compound of formula (XXIII) is not isolated; and reacting the compound of formula (XXIII) with a compound of formula (XXIV); in the presence of a reducing agent; in a third organic solvent; to yield the corresponding compound of formula (II); wherein the first organic solvent, the second organic solvent and the third organic solvent are the same and optionally reacting the compound of formula (II) to yield the corresponding hydrate or pharmaceutically acceptable salt, ester or amide of the compound of formula (II).