Patent ID: 7615618
Filing Date: 2009-11-10
Classification: A61P,C07H,C12N

Abstract:
1. A double-stranded oligonucleotide comprising a first strand and a second strand, wherein said first strand and said second strand are represented independently by formula II: wherein X M represents independently for each occurrence an alkali metal or a transition metal with an overall charge of +1; R R R R R k represents independently for each occurrence 1, 2, 3, or 4; n n w represents independently for each occurrence 1, 2, or 3 in accord with the rules of valence; x represents independently for each occurrence 0, 1, 2, or 3; y represents independently for each occurrence 1, 2, 3, 4, or 5 in accord with the rules of valence; A A A A B B R represents independently for each occurrence hydrogen or alkyl; m represents independently for each occurrence 1, 2, 3, 4, 5, 6, 7, or 8; m Y represents independently for each occurrence an alkyl diradical, cycloalkyl diradical, heteroalkyl diradical, heterocycloalkyl diradical, alkenyl diradical, alkynyl diradical, aryl diradical, heteroaryl diradical, aralkyl diradical, heteroaralkyl diradical, —X  —[C(R X Z Z R R t represents independently for each occurrence 0, 1, 2, 3, or 4; v represents independently for each occurrence 0, 1, 2, 3, 4, 5, 6, 7, or 8; A A Z Z R R R R B B n n A p represents independently for each occurrence 1, 2, 3, or 4; B A R R R B B A B provided that at least one instance of Y is not  and A