Patent ID: 6455529
Filing Date: 2002-09-24
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula I in which withB=CH2, CO or CS, R10=OH or H and m=0, 1, 2, 3 or 4; or withB=CH2, CO or CS, U=CH2 or CO and R9=H, CO2H or CO2A, and q=0, 1, 2 or 3; R1 is H, A, Arâ€”CO, Aâ€”CO, OH, OA or AOâ€”CO; R2 is OH, OA, OAr, OHet, NHOH, NH2, NHA or NA2; R3 is Aâ€”CO, Arâ€”CO, Hetâ€”CO, Hetâ€”Oâ€”CO, Arâ€”Oâ€”CO, Aâ€”Oâ€”CO, Arâ€”SO2 or Aâ€”SO2; A is alkyl with 1 to 6 C atoms; Ar is aryl of 6 to 10 C atoms, or diphenylmethyl or benzyl which are unsubstituted or substituted once, twice or three times by A, F, Cl, Br, I, OA, â€”Oâ€”CH2â€”Oâ€”, COOA, COOH, CF3, OH, NO2, CN, NH2, Oâ€”COâ€”A, NHA or NA2; and Het is a mono- or binuclear saturated, unsaturated or aromatic heterocycle with 1 to 4 N, O and/or S atoms, which can be unsubstituted or substituted once by F, Cl, Br, CF3, A, OH, OA, CN or NO2, and their physiologically acceptable salts and solvates.