Patent ID: 9052328
Filing Date: 2015-06-09
Classification: G01N

Abstract:
1. A method for determining whether a subject not undergoing statin treatment is at risk to develop one or more cardiovascular disease (CVD) complications, comprising a. determining in a sample from said subject one or more lipid-lipid concentration ratio(s), wherein (an) increased or decreased lipid-lipid concentration ratio(s) in said sample, when compared to a control sample, is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-lipid concentration ratio(s) whose increase(s) is (are) compared to the control is (are) selected from: Cer(d18:1/18:0)/Cer(d18:1/24:0), Cer(d18:1/20:0)/Cer(d18:1/24:0) and Cer(d18:1/22:0)/Cer(d18:1/24:0); and wherein the one or more lipid-lipid concentration ratio(s) whose decrease(s) is (are) compared to the control is (are) selected from: Cer(d18:1/24:0)/Cer(d18:1/24:1), Cer(d18:1/24:0)/PC 16:0/18:2, Cer(d18:1/24:0)/SM (d18:1/14:0) (d18:1/13:1-OH), Cer(d18:1/24:0)/Gb3(d18:1/16:0) and Cer(d18:1/24:0)/SM (d18:1/16:1) (d18:1/15:2-OH); or b. determining in a sample from said subject one or more lipid-clinical concentration ratio(s), wherein a decreased lipid-clinical concentration ratio(s) in said sample, when compared to a control sample, is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-clinical concentration ratio(s) whose decrease is compared to the control is Cer(d18:1/24:0)/supersensitive C-reactive protein (mg/L).