Patent ID: 6063817
Filing Date: 2000-05-16
Classification: A61K,A61P,Y10S

Abstract:
A method of preventing or reducing the severity of an ischemic injury originating in an animal's dermal tissue comprising administering to the animal a composition comprising a compound of formula I*: ##STR9## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 -- or --CR.sup.5 .dbd.CR.sup.6 --;n is 1 or 0;R.sup.m and R.sup.k are independently hydrogen, halogen, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkyloxy or nitro;R.sup.4 is --(CH.sub.2).sub.t --Y.sup.b, C.sub.1-6 alkyl, or C.sub.3-6 cycloalkyl;R.sup.1 is --CO.sub.2 Z, C.sub.1-6 alkyl, CH.sub.2 OH, -CONHR.sup.y, or CHO;R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl, or R.sup.a and R.sup.b together can form a radical of the formula: ##STR10## Y.sup.b is naphthyl or phenyl, both radicals can be optionally substituted with one to three of C.sub.1-6 alkyl or halogen, which substituents can be the same or different;Z is hydrogen or C.sub.1-6 alkyl;R.sup.2, R.sup.3, R.sup.5, R.sup.6, and R.sup.y are independently hydrogen or C.sub.1-6 alkyl; andt is zero to six.