Patent ID: 8207236
Filing Date: 2012-06-26
Classification: A61K

Abstract:
1. A method of producing porous particles comprising: providing a first aqueous solution comprising a porosity-promoting agent dissolved in water; providing an organic solution comprising a therapeutic constituent dissolved or suspended in an organic solvent; providing a second aqueous solution comprising a surfactant; emulsifying the first aqueous solution into the organic solution to form a water-in-oil emulsion; emulsifying the water-in-oil emulsion into the second aqueous solution to form a water-in-oil-in-water emulsion in which an internal aqueous phase of the water-in-oil-in-water emulsion is formed from the first aqueous solution, an oil phase of the water-in-oil-in-water emulsion is formed from the organic solution, and an external aqueous phase of the water-in-oil-in-water emulsion is formed from the second aqueous solution; and extracting the organic solvent from the oil phase of the water-in-oil-in-water emulsion using a supercritical fluid to cause precipitation of the therapeutic constituent, said porosity-promoting agent in the internal aqueous phase promoting osmosis of water from one of the internal aqueous phase and the external aqueous phase to the other of the internal aqueous phase and the external aqueous phase during extraction and precipitation of the therapeutic constituent such that an aqueous suspension of porous particles comprising the therapeutic constituent is formed.