Patent ID: 6124312
Filing Date: 2000-09-26
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR65## R is selected from the group consisting of --OR.sup.4, --SR.sup.4 and SO.sub.2 R.sup.4 ;R.sup.4 is selected from the group consisting of C.sub.1-15 -alkyl, C.sub.2-15 -alkenyl, C.sub.2-15 -alkynyl, fused aromatic, and 5-membered heterocycle; each of which is optionally substituted with one or more independently selected from the group consisting of C.sub.3 -C.sub.8 cycloalkyl, halogen, --CF.sub.3, --CN, C.sub.1-4 alkoxy, fused aromatic, 5-membered heterocycle, phenyl and phenoxy wherein phenyl, fused aromatic, and phenoxy is optionally substituted with one or more independently selected from the group consisting of halogen, --CN, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, --OCF.sub.3, --CF.sub.3, --CONH.sub.2 and --CSNH.sub.2 ;R.sup.16' is carbon or nitrogen;R.sup.17' is carbon or nitrogen;provided that one, and only one, of R.sup.16' and R.sup.17' must be nitrogen and when R.sup.16' is nitrogen then R.sup.17' is carbon and when R.sup.17' is nitrogen then R.sup.16' is carbon;R.sup.15' is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkenyl, C.sub.1-4 alkynyl, --C(O)OR.sup.20' and C.sub.3 -C.sub.8 cycloalkyl;R.sup.20"" is C.sub.1 -C.sub.6 alkyl; ora pharmaceutically acceptable salt or solvate thereof.