Patent ID: 6144869
Filing Date: 2000-11-07
Classification: A61B,A61N,C12Q

Abstract:
A method for measuring the concentration of an analyte present in a biological system, said method comprisinga measurement cycle which comprises an extraction step in which a sample containing the analyte is transdermally extracted from the biological system using a sampling system that is in operative contact with a skin or mucosal surface of said biological system, anda sensing step in which the extracted sample is contacted with sensor means to obtain a measurement signal that is related to analyte concentration,wherein said measurement cycle further comprises a process for selectively favoring analyte-specific signal components over signal components due to interfering species, said process selected from the group consisting of (a) a differential signal process which subtracts non-analyte signal components from the measurement signal, (b) a delay step which is performed between the extraction and sensing steps, (c) a selective electrochemical detection process which is performed during the sensing step, (d) a purge step which is performed after the sensing step, (e) a charge segregation step, and (f) any combination thereof.