Patent ID: 6645983
Filing Date: 2003-11-11
Classification: A61K,A61P,C07D

Abstract:
A pharmaceutical composition with activity on the proliferation of clonogenic cells in tumors and which comprises an effective amount of a compound chosen from the compounds of formulae: in which:R1 is chosen from H, OH, C1-C4 alkyl groups, C2-C4 alkenyl groups, C1-C4 alkoxy groups, phenyl groups or a phenyl group substituted 1 to 3 times with groups chosen from H, OH, a group â€”OCOR7, wherein R7 is a C1-C4 alkyl group, a group â€”Oâ€”SO2â€”Râ€²7, Râ€²7 is a C1-C4 alkyl group or a CF3 group, and a group â€”NR16R17, wherein R16 and R17 are chosen, independently of each other, from hydrogen, C1-C4 alkyl groups, C2-C4 alkenyl groups, phenyl(C1-C4)alkyl groups or a phenyl(C1-C4)alkyl group substituted 1 to 3 times on the alkyl group with groups chosen from H, OH and C1-C4 alkoxy, or a dimethylamino (C1-C4)alkyl group, or together forming, with the nitrogen atom, a 5- or 6-membered heterocycle optionally comprising one or more hetero atoms chosen from oxygen, nitrogen and sulfur, or a methylpiperazinyl group; R2, R3 and R4 are chosen, independently of each other, from H, OH, a C1-C4 alkyl group, a C1-C4 alkoxy group, a group â€”OCOâ€”R7, and a group derived from a saccharide, optionally R2 and R3 together forming a methylenedioxy group, R5 is a phenyl group or a phenyl group substituted 1 to 3 times with groups chosen from H, a C1-C4 alkoxy group, a group â€”OCOR7, a phenyl (C1-C4) alkoxy group, a group â€”Oâ€”SO2â€”Râ€²7, wherein Râ€²7 is a C1-C4 alkyl group or a CF3 group, a benzylamino group and a group derived from a saccharide; R6 is chosen from H, a C1-C4 alkyl group, a C2-C4 alkenyl group, a group â€”COâ€”R8 and a group â€”Aâ€”R9; R6a is chosen from a C1-C4 alkyl group, a C2-C4 alkenyl group, a group â€”COâ€”R8 and a group â€”Aâ€”R9; R8 is a C1C4 alkyl group; A is a C1-C4 alkylene group; R9 is chosen from 5- or 6-membered heterocyclic groups containing 1 to 4 hetero atoms chosen from oxygen, sulfur and nitrogen, CN, hydroxyl, â€”COOR10 and CONR11R12 groups, a group â€”NR13R14, a group â€”COR15 and a group OSO2R16; R10, R11, R12, R13, R14 and R15 are independently chosen from a hydrogen atom, a C1-C4 alkyl group and a phenyl (C1-C4) alkyl group, R16 is chosen from a phenyl group and a (C1-C4) alkylphenyl group, and optionally R4 and R6 are together and form a â€”COâ€”CH2â€”CH2-group.