Patent ID: 9206394
Filing Date: 2015-12-08
Classification: A61K,C12N

Abstract:
1. A method for producing a human T cell which expresses TCR α and β chains and CCR7, comprising the steps of: (i) inducing an iPS cell from a human T cell, wherein the human T cell which is induced into the iPS cell expresses TCR α and β chains and has antigen specificity, (ii) differentiating the iPS cell into a T-lineage cell, (III) stimulating the TCR of the redifferentiated T-lineage cell before the transition from the double negative (DN) stage to the double positive (DP) stage, and (iv) culturing the stimulated T-lineage cell until the cell differentiates into a T cell which expresses CCR7 and TCR α and β chains, and has antigen specificity that is identical to that of the human T cell which was differentiated into the iPS cell.