Patent ID: 8487099
Filing Date: 2013-07-16
Classification: A61P,C07D,C07F

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein G is —O— or O—C—(R3) Spiro Ring (A) is selected from the group consisting of: cycloalkyl, cycloalkenyl, heterocycloalkyl, and heterocycloalkenyl, wherein: (a) said cycloalkyl ring (A) is a 3 to 8 carbon membered ring (including the carbon atom common to both rings (A) and (B)), and (b) said cycloalkenyl ring (A) is a 5 to 8 carbon membered ring (including the carbon atom common to both rings (A) and (B)) comprising one or two double bonds, provided that there is no double bond to the carbon common to Rings (A) and (B) and (c) said heterocycloalkyl Ring (A) is a 4 to 8 membered ring (including the carbon atom common to Rings (A) and (B)) comprising 1 to 3 ring members independently selected from the group consisting of: O, S, NR (d) said heterocycloalkenyl Ring (A) is a 5 to 8 membered ring (including the carbon atom common to Rings (A) and (B)) comprising one or two double bonds, and comprising 1 to 3 ring members independently selected from the group consisting of: O, S, NR (e) wherein said Spiro Ring (A) is optionally fused with an aryl ring, or is optionally fused with a heteroaryl ring, to form a fused Spiro Ring (A) moiety, and (f) wherein said Spiro Ring (A) is optionally substituted with 1 to 3 substituents independently selected from the group consisting of: alkyl, alkenyl, alkynyl, —CN, halo, —C(O)R —C(O)N(R 15 )(R 16 ), —S(O)N(R 15 )(R 16 ), —S(O) 2 N(R 15 )(R 16 ), —C(═NOR 15 )R 16 , —P(O)(OR 15 )(OR 16 ), —OR 15 (e.g., —OCH 3 ), and —S(O) 2 R 15A (e.g., —S(O) 2 CH 3 ); R R R R