Patent ID: 6995022
Filing Date: 2006-02-07
Classification: B01D

Abstract:
1. A high throughput method for determining whether a known compound or a mixture of compounds is suitable for intended use as a drug, said method comprising: (a) placing a first solution comprising biological material having higher molecular weights than the compound or the mixture of compounds, into an ultrafiltration chamber, said chamber comprising a membrane with pore sizes that will not allow passage of the biological material out of the chamber; (b) placing the compound or the mixture of compounds into the ultrafiltration chamber, said chamber comprising a membrane with pore sizes that allow passage of the compound or the mixture of compounds out of the chamber; (c) providing a continuous flow of a supportive solution to the ultrafiltration chamber that facilitates reactions between the biological material and the compound or the mixture mixtures of compounds to produce products of the reactions that are different from the compound or mixture of compounds in function or structure or both function and structure, wherein the ultrafiltration chamber allows passage of the products out of the chamber to form a second solution, but does not allow passage of the biological materials; (d) analyzing the second solution comprising the products of the reactions between the biological material and the compound or the mixture of compounds, to determine whether the compound or any of the mixture of compounds is suitable for use as a drug by analyzing the products in the second solution.