Patent ID: 8969561
Filing Date: 2015-03-03
Classification: C07D,C07F

Abstract:
1. A process for the preparation of a compound of formula (II), as a single stereoisomer or a mixture thereof, or a salt thereof wherein each of X and Y, being the same or different, is an optionally substituted C 1 -C 12 alkyl group; an optionally substituted C 3 -C 12 cycloalkyl group; an optionally substituted aryl group; an optionally substituted C 1 -C 12 alkoxy group; a halogen; hydroxy; cyano; nitro; an amine group —NR′R″ or an amide group —NR′COR″, wherein each of R′ and R″, which are the same or different, is hydrogen, an optionally substituted C 1 -C 12 alkyl group, an optionally substituted C 3 -C 12 cycloalkyl group, an optionally substituted aryl group, or R′ and R″, taken together, complete a heterocyclic C 2 -C 7 ring; R is an optionally substituted C wherein R 1 is an optionally substituted C 3 -C 12 cycloalkyl group; an optionally substituted aryl-C 1 -C 12 alkyl group; a silyl group of formula (R 2 ) 3 Si—, wherein each R 2 , which are the same or different, is selected from the group consisting of an optionally substituted C 1 -C 12 alkyl, optionally substituted C 3 -C 12 cycloalkyl, optionally substituted C 1 -C 12 alkoxy and optionally substituted aryl; or a sulphonyl group R 3 SO 2 —, wherein R 3 is an optionally substituted C 1 -C 12 alkyl group, an optionally substituted C 3 -C 12 cycloalkyl group, an optionally substituted aryl group, an optionally substituted aryl-C 1 -C 12 alkyl group; or an R 3 CO— acyl group wherein R 3 is as defined above, and Y is defined above; and a compound of formula (IV), wherein R is an optionally substituted C 3 -C 12 cycloalkyl group; an optionally substituted aryl-C 1 -C 12 alkyl group; a silyl group of formula (R 2 ) 3 Si—, wherein each R 2 , which are the same or different, is selected from the group consisting of an optionally substituted C 1 -C 12 alkyl, optionally substituted C 3 -C 12 cycloalkyl, optionally substituted C 1 -C 12 alkoxy and optionally substituted aryl; or a sulphonyl group R 3 SO 2 —, wherein R 3 is an optionally substituted C 1 -C 12 alkyl group, an optionally substituted C 3 -C 12 cycloalkyl group, an optionally substituted aryl group; an optionally substituted aryl-C 1 -C 12 alkyl group; or an R 3 CO— acyl group wherein R 3 is as defined above; Z is halogen or a sulphonyl group of formula R R, X and Y are as defined above; and,