Patent ID: 9199985
Filing Date: 2015-12-01
Classification: A61K,C07D

Abstract:
1. A method of lowering blood pressure in an individual in need thereof comprising administering to the individual an effective amount of a compound of formulae (IA), (IB), (J-1) or (K-1), or a salt, solvate or N-oxide thereof, wherein: formula (IA) is: wherein: R each R each R each R each X Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted of unsubstituted aralkyl, wherein the aralkyl is a fused ring system where at least one cycloalkyl moiety is fused with at least one aryl moiety and wherein the aralkyl is attached to the parent structure via the cycloalkyl moiety or the aryl moiety; and R provided that: (1) at least one of X (2) when each X (3) when each X (4) when each X formula (IB) is: wherein: R each R each R each R each X Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aralkyl, wherein the aralkyl is a fused ring system where at least one cycloalkyl moiety is fused with at least one aryl moiety and wherein the aralkyl is attached to the parent structure via the cycloalkyl moiety or the aryl moiety; and R provided that: (1) at least one of X (2) when none of X (3) when none of X (4) when each X formula (J-1) is: wherein: R each R each X Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted aralkyl, wherein the aralkyl is a fused ring system where at least one cycloalkyl moiety is fused with at least one aryl moiety and wherein the aralkyl is attached to the parent structure via the cycloalkyl moiety or the aryl moiety; and R provided that at least one of X and formula (K-1) is: wherein: R each R each X Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted aralkyl, wherein the aralkyl is a fused ring system where at least one cycloalkyl moiety is fused with at least one aryl moiety and wherein the aralkyl is attached to the parent structure via the cycloalkyl moiety or the aryl moiety; and R provided that at least one of X and wherein the individual has high blood pressure or has one or more risk factors for developing high blood pressure.