Patent ID: 6043242
Filing Date: 2000-03-28
Classification: A61P,C07D

Abstract:
A compound of the formula I ##STR4## in which R1 is hydrogen, 1-4C-alkyl, 1-4C-alkyl substituted by R11, 1-4C-alkylcarbonyl, 1-4C-alkoxycarbonyl, sulfo (--SO.sub.3 H) or a cyclic system or bicyclic system substituted by R11 and R12, which is selected from the group consisting of pyrrole, furan, thiophene, pyrazole, imidazole, imidazoline, oxazole, isoxazole, thiazole, thiazoline, isothiazole, triazole, oxadiazole, thiadiazole, thiadiazole-1-oxide, tetrazole, hexopyranoses, benzene, pyridine, pyridine-N-oxide, pyridazine, pyrimidine, pyrazine, triazine, naphthalene, quinoline, quinazoline, quinoxaline, benzimidazole, benzoxazole, benzothiazole, thiazolopyridine and imidazopyridine,whereR11 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkoxy, 1-4C-alkylcarbonyl, amino, 1-4C-alkylcarbonylamino, halogen, trifluoromethyl, trifluoromethoxy, hydroxyl, carboxyl, 1-4C-alkoxycarbonyl, 1-4C-alkylthio, 1-4C-alkylsulfinyl, 1-4C-alkylsulfonyl, sulfo (--SO.sub.3 H), nitro, guanidino, phenyl, phenyl substituted by R111, pyridyl, pyridyl substituted by R111, imidazolyldione, thiazolyl, 1-4C-alkyl substituted by R111, --N(R112)R113 or --CO--N(R112)R113 andR12 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, halogen, amino, hydroxyl, phenyl or trifluoromethyl,whereR111 is hydroxyl, 1-4C-alkyl, 1-4C-alkoxy, carboxyl, 1-4C-alkoxycarbonyl, halogen, aminosulfonyl or --N(R112)R113,R112 is hydrogen, 1-4C-alkyl, formyl, 1-4C-alkylcarbonyl or 1-4C-alkoxycarbonyl andR113 is hydrogen or 1-4C-alkyl, or whereR112 and R113, together and including the nitrogen atom to which both are bonded, are a piperidino or morpholino radical,R2 is hydrogen, 1-4C-alkyl or halogen,A is 2-7C-alkylene,X is a bonding dash, O (oxygen) or S (sulfur),Y is O (oxygen), S (sulfur) or N-1-4C-alkyl andZ is O (oxygen) or S (sulfur), or a salt of this compound, its N-oxide or the salts of the N-oxides.