Patent ID: 7687475
Filing Date: 2010-03-30
Classification: A61P,C12N

Abstract:
1. A precursor RNAi molecule capable of inhibiting the expression of a target sequence comprising a first oligonucleotide strand that is 22-30 nucleotides in length; and a second oligonucleotide strand that is 22-30 nucleotides in length and comprises a nucleotide sequence that is sufficiently complementary to a sequence of an RNA of a target gene to direct target-specific RNAi and wherein the second oligonucleotide strand anneals to the first oligonucleotide strand under biological conditions, wherein the precursor RNAi molecule is a substrate for a Dicer, wherein the target sequence encodes a respiratory syncytial virus (RSV)-specific mRNA, wherein the precursor RNAi molecule is capable of inhibiting the expression of a respiratory syncytial virus (RSV)-specific messenger RNA (mRNA) to which it corresponds, and wherein the first oligonucleotide strand comprises SEQ ID NO:273 and the second oligonucleotide strand comprises SEQ ID NO:274.