Patent ID: 8248071
Filing Date: 2012-08-21
Classification: G01N,G01R

Abstract:
1. A method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts, said method comprising: providing a sample; applying radiofrequency pulses for an N-dimensional NMR experiment to said sample; selecting m dimensions of said NMR experiment, wherein m≦N; sampling a time domain modulation in a phase-sensitive manner in each selected dimension jε[1,2, . . . , m] arising from time evolution of chemical shift α I j,ψ + and I j,ψ ,δ − are amplitudes, Ψ j and Ψ j +δ j are primary phase shifts with Ψ j , δ j ε[0,2π[and the cases {ψ j =nπ/2 and δ j =mπ} with n=0, 1, 2, 3 and m=0, 1 being omitted, and Φ j,ψ + and Φ j,ψ ,δ − are secondary phase shifts; multiplying each said vectors C and a vector Q=[1 i], wherein i=√{square root over (−1)}, according to Q·D j ·C j,ψ t j ) under conditions effective to create a complex time domain of said selected m dimensions according to transforming said complex time domain into frequency domain by use of an operator O under conditions effective to measure the values of I