Patent ID: 6835382
Filing Date: 2004-12-28
Classification: A61K,C07K

Abstract:
A method for inhibiting presentation of an MHC class II-restricted antigenic peptide to a T cell, comprising:a) forming an incubation mixture comprising the following components under physiological conditions: i) an MHC class II-expressing antigen presenting cell displaying on its surface the MHC class II-restricted antigenic peptide; ii) a peptide selected from the group of peptides consisting of SEQ ID NOS: 16, 18, 19, 22, 24, 25, and any one listed in Tables 20-39; and b) contacting the incubated components of step a) with a T cell which is responsive to the MHC class II-restricted antigenic peptide under physiological conditions wherein the peptide of ii) inhibits the presentation of the MHC class II-restricted antigenic peptide to the T cell.