Patent ID: 6020331
Filing Date: 2000-02-01
Classification: A61K,C07K

Abstract:
A fused bicyclic ring compound having the structure: ##STR180## and pharmaceutically acceptable salts thereof, whereinA is --(CH.sub.2).sub.1-4 --;B is N;C is --(CH.sub.2).sub.1-3 --;R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is independently selected from an amino acid side chain or an amino acid side chain derivative, with the proviso that R.sub.1 is not hydrogen;R.sub.4 is an organoamine comprising 2-10 carbon atoms and at least 1 nitrogen atom;R.sub.5 is selected from the group consisting of:(a) alkyl of 1 to about 12 carbon atoms, optionally substituted with one to four substituents independently selected from halide, C.sub.1-5 alkoxy and nitro,(b) --C(.dbd.O)NH--C.sub.1-5 alkyl, wherein the alkyl group is optionally substituted with halide or C.sub.1-5 alkoxy,(c) --C(.dbd.O)NH--C.sub.1-5 aralkyl wherein the aryl group is optionally substituted with up to five substituents independently selected from nitro, halide, --NH--(C.dbd.O)C.sub.1-5 alkyl, --NH--(C.dbd.O)C.sub.6-10 aryl, C.sub.1-5 alkyl and C.sub.1-5 alkoxy, and(d) monocyclic and bicyclic heteroaryl of 4 to about 11 ring atoms, wherein the ring atoms are selected from carbon and the heteroatoms oxygen, nitrogen and sulfur, and wherein the heteroaryl ring may be optionally substituted with up to about 4 substituents independently selected from halide, C.sub.1-5 alkyl, C.sub.1-5 alkoxy, --C(.dbd.O)NHC.sub.1-5 alkyl, --C(.dbd.O)NHC.sub.6-10 aryl, amino, --C(.dbd.O)OC.sub.1-5 alkyl and --C(.dbd.O)OC.sub.6-10 aryl; andZ represents a chemical moiety;and wherein any two adjacent CH groups of the fused bicyclic ring may optionally form a double bond.