Patent ID: 6417362
Filing Date: 2002-07-09
Classification: C07D,G03F,Y10S

Abstract:
A compound represented by formula (I) and pharmaceutically acceptable salt and solvate thereof: whereinA represents group â€”CR1R2â€”(CH2)iâ€” wherein R1 and R2, which may be the same or different, represent a hydrogen atom or alkyl having 1 to 6 carbon atoms and i is an integer of 1, â€”CH&boxH;CHâ€”, â€”Oâ€”CH2â€”, or â€”S(O)jâ€”CH2â€” wherein j is an integer of 0 to 2; B represents a hydrogen or halogen atom; X represents â€”CR3R4R5 wherein R3, R4, and R5, which may be the same or different, each represent a hydrogen atom or phenyl, provided that any one of R3, R4, and R5 represents phenyl and one or more hydrogen atoms on phenyl may be substituted by a halogen atom, hydroxyl, nitro, phenyl, or alkoxy having 1 to 6 carbon atoms, â€”(CH2â€”CH&boxH;C(CH3)â€”CH2)pâ€”CH2CH&boxH;C(CH3)2 wherein p is an integer of 0 to 2, alkyl having 1 to 18 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, phenyl optionally substituted by hydroxy, a halogen atom, nitro, alkoxy having 1 to 6 carbon atoms, or phenyl, or cinnamyl optionally substituted by hydroxy, a halogen atom, nitro, phenyl, or alkoxy having 1 to 6 carbon atoms; Y represents â€”(CH2)qâ€” wherein q is an integer of 1 to 6, â€”CH&boxH;CHâ€”, or a bond; Z represents a bond; K represents alkylene having 1 to 6 carbon atoms optionally substituted by hydroxy, a halogen atom, alkyl having 1 to 6 carbon atoms, or alkoxy having 1 to 6 carbon atoms, or represents a bond; L represents â€”CH&boxH;CHâ€” or a bond; and M represents a hydrogen atom, alkyl having 1 to 6 carbon atoms optionally substituted by hydroxy, a halogen atom, amino, alkoxy having 1 to 6 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 8 carbon atoms optionally substituted by hydroxy, a halogen atom, amino, alkoxy having 1 to 6 carbon atoms, alkylcarbonyloxy having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms, phenyl optionally substituted by alkyl having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms, a five- or six-membered, saturated or unsaturated heterocyclic ring containing up to two hetero atoms optionally substituted by alkyl having 1 to 4 carbon atoms, biphenyl optionally substituted by alkyl having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms, or diphenylmethyl optionally substituted by alkyl, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms.