Patent ID: 6352990
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound having the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein:A and C are N, and B is CR; R is selected from hydrogen and C1-6(alkyl; R1 is selected from NR3R4 and R5; R2 is C1-6alkyl; R3 is selected from hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl; C3-6alkenyl; hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl and C1-6alkyloxyC1-6R4 and R5 are independently selected from C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar1CH2, C3-6alkenyl, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl; or a radical of the formula â€”(C1-6alkanediyl)-Oâ€”COâ€”Ar1; or R3 and R4 taken together with the nitrogen atom to which they are attached form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C1-6alkyl or C1-6alkyloxy; Ar is selected from phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, triflouromethyl, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino and mono- and di(C1-6alkyl)amino; and pyridinyl substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, triflouromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino, mono- and di(C1-6alkyl)amino and piperidinyl; and Ar1 is selected from phenyl, pyridinyl, and phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, C1-6alkyloxy, di(C1-6alkyl)aminoC1-6alkyl, triflouromethyl and C1-6alkyl substituted with morpholinyl.