Patent ID: 6579690
Filing Date: 2003-06-17
Classification: A61B,Y10S

Abstract:
A process for determining glucose concentration in blood, comprising:determining, from a sample of subcutaneous fluid, a subcutaneous glucose concentration, and from the subcutaneous glucose concentration, a glucose concentration in blood by calculation (i) based on a model accounting for mass transfer of the glucose from blood to a subcutaneous region and uptake of the glucose by subcutaneous tissue, and (ii) utilizing a regularization technique in the calculation, wherein the blood glucose concentration is determined from the subcutaneous glucose concentration using the relationship: &dd;S&dd;t=km&it;A&af;(B-S)-Vkrâ€²&it;SKm+Sâ€²â€ƒwhere V is the volume of the sensor, S is the subcutaneous glucose concentration, B is the blood glucose concentration, A is the surface area of the region surrounding the sensor, km is a mass transfer coefficient, Km is a Michaelis-Menten constant, and krâ€² is the reaction rate constant for uptake of glucose by the subcutaneous tissue.