Patent ID: 8703724
Filing Date: 2014-04-22
Classification: A61K,A61P

Abstract:
1. A formulation comprising an anthracycline compound and an aromatic or heterocyclic compound, wherein the anthracycline compound has the general formula: wherein R R 2 is a glycoside, R 4 and R 5 independently are H, OH, C 1 -C 4 alkyl, OC 1 -C 4 alkyl or C(CH 2 R 3 )═N—NH—CO—X—Y, wherein R X is a linking group selected from the group consisting of —(CH Y is a binding group selected from the group consisting of a maleinimide group, a halogen acetate amide group, a halogen acetate group, a pyridyldithio group, an N-hydroxysuccinimide ester group, isothiocyanate group, a disulfide group, a vinylcarbonyl group, an aziridine group and an acetylene group, with the proviso that at least one of R 4 and R 5 is C(CH 2 R 3 )═N—NH—CO—X—Y, and wherein the aromatic or heterocyclic compound is an N-acetyl substituted amino acid selected from the group consisting of D-N-acetyltryptophan, L-N-acetyltryptophan, and D,L-N-acetyltryptophan.