Patent ID: 6329390
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A compound according to Formula I and a salt, solvate or hydrate thereof, ##STR20##wherein:R.sup.1 is selected from the group consisting of CR.sup.5 R.sup.6 CH.sub.2 NR.sup.7 R.sup.8 group of Formula II: ##STR21##R.sup.2 is selected from the group consisting of H, OH, C.sub.1-6 alkyl and C.sub.1-6 alkoxy;R.sup.3 is selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy,C.sub.1-6 alkylthio and optionally substituted benzyloxy;n is selected from the group consisting of a integer of from 1-3;Z is selected from the group consisting of C and N;---------- represents a single or double bond provided that only one double bond is present in the ring at a time;R.sup.4 is selected from the group consisting of H, OH, C.sub.1-6 alkoxy or null, provided that when R.sup.4 is selected from the group consisting of H, OH and C.sub.1-6 alkoxy, Z is C and ---------- represents a single bond and when R.sup.4 is null, either Z is C and ---------- represents a double bond or Z is N and ---------- represents a single bond;one of R.sup.5 and R.sup.6 is independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 alkoxy and hydroxy and the other of R.sup.5 and R.sup.6 is F;R.sup.7 and R.sup.8 are independently selected from H and C.sub.1-6 -alkyl or R.sup.7 and R.sup.8 form an alkylene bridge which optionally incorporates a heteroatom selected from O, NR.sup.9 and S, and which, together with the nitrogen atom to which they are attached, creates ail optionally substituted 3- to 7-membered carbo- or heterocyclic ring; andR.sup.9 is selected from the group consisting H, C.sub.1-6 -alkyl and optionally substituted benzyl.