Patent ID: 6333341
Filing Date: 2001-12-25
Classification: A61P,C07D,Y10S

Abstract:
A compound of the formula ##STR29##or a pharmaceutically acceptable salt thereof, whereinX is O, S, S(O), S(O).sub.2 or NR.sup.2 ;Y is --C(O)--NR.sup.3 R.sup.4 or --NR.sup.4 --C(O)--R.sup.3 ;R.sup.1 is a heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R.sup.18 --Z.sup.18 -- or R.sup.18 --Z.sup.18 --alkyl; provided that R.sup.1 is other than an optionally substituted pyridyl radical; and provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R.sup.1 is 1-3; and provided when Y is --NR.sup.4 --C(O)--R.sup.3 and X is O or S, R.sup.1 is other than a 2-pyrimidinyl radical;R.sup.2 is a hydrogen or alkyl radical;R.sup.3 is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals or alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R.sup.19 --Z.sup.19 -- or R.sup.19 --Z.sup.19 --alkyl; provided that the total number of aryl and heteroaryl radicals in R.sup.3 is 1-3; and provided when Y is --C(O)--NR.sup.3 R.sup.4, R.sup.3 is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon atom adjacent to the ring carbon atom bonded to --NR.sup.4 --; andR.sup.4 is a hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or R.sup.20 --Z.sup.20 --alkyl radical;wherein R.sup.18, R.sup.19 and R.sup.20 are each independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical; wherein the aryl and heteroaryl radicals of R.sup.4, R.sup.18, R.sup.19 and R.sup.20 are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl, cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; andZ.sup.18, Z.sup.19 and Z.sup.20 are each independently --O--, --S--, --S(O)--, --S(O).sub.2 --, --CO.sub.2 --, --C(O)--, --NR.sup.21 --, --NR.sup.21 --C(O)--, --C(O)--NR.sup.21 --, --NR.sup.21 --S(O).sub.2 -- or --S(O).sub.2 --NR.sup.21 --; wherein each R.sup.21 is independently a hydrogen or alkyl radical;R.sup.5 and R.sup.6 are each independently a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical; andR.sup.7 is a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical.