Patent ID: 6207852
Filing Date: 2001-03-27
Classification: A61K,A61P,C07C

Abstract:
A compound represented by the following formula: ##STR20##including stereochemically isomeric forms thereof and pharmaceutically acceptable salts thereof, wherein:X is oxygen, --NH or methylene;R.sub.1 and R.sub.2 are independently selected from the group consisting of: hydrogen, an alkyl group having 1 to 4 carbon atoms, (CH.sub.2).sub.2 O and (CH.sub.2).sub.3 OH, with the proviso that:(1) when X is oxygen:R.sub.1 and R.sub.2 are not both CH.sub.3 ;R.sub.1 and R.sub.2 are not both C.sub.2 H.sub.5 ;R.sub.1 and R.sub.2 are not both C.sub.3 H.sub.7 ;R.sub.1 and R.sub.2 are not both C.sub.4 H.sub.9 ;R.sub.1 is not C.sub.2 H.sub.5, when R.sub.2 is hydrogen; andR.sub.1 is not CH.sub.3 when R.sub.2 is C.sub.2 H.sub.5 ;(2) when X is --NH:R.sub.1 is not hydrogen when R.sub.2 is CH.sub.3 when said compound is in the racemic form;R.sub.1 is not hydrogen when R.sub.2 is C.sub.2 H.sub.5 ;R.sub.1 and R.sub.2 are not both CH.sub.3 ;R.sub.1 and R.sub.2 are not both C.sub.2 H.sub.5 ;R.sub.1 and R.sub.2 are not both C.sub.3 H.sub.7 ;R.sub.1 and R.sub.2 are not both C.sub.4 H.sub.9 ;R.sub.1 is not (CH.sub.2).sub.2 OH when R.sub.2 is hydrogen or CH.sub.3 or C.sub.2 H.sub.5, when said compound is in the racemic form;R.sub.1 is not (CH.sub.2).sub.3 OH when R.sub.2 is hydrogen or CH.sub.3 or C.sub.2 H.sub.5, when said compound is in the racemic form;(3) when X is methylene:R.sub.1 and R.sub.2 are not both hydrogen when said compound is in the racemic form or in the R-form;R.sub.1 and R.sub.2 are not both CH.sub.3 when said compound is in the racemic form or in the R-form;R.sub.1 and R.sub.2 are not both C.sub.2 H.sub.5 when said compound is in the racemic form or in the R-form;R.sub.1 is not hydrogen when R.sub.2 is CH.sub.3 when said compound is in the racemic form or in the R-form; andR.sub.1 is not hydrogen when R.sub.2 is C.sub.2 H.sub.5 when said compound is in the racemic form or in the R-form.