Patent ID: 6362204
Filing Date: 2002-03-26
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of formula (1): whereinR1 is an optionally substituted aromatic or heteroaromatic group; Alk1 is an optionally substituted aliphatic or heteroaliphatic chain; L1 is a linker atom or group selected from â€”Oâ€”, â€”Sâ€”, â€”C(O)â€”, â€”C(O)Oâ€”, â€”C(S)â€”, â€”S(O)â€”, â€”S(O)2â€”, â€”N(R8)â€”, â€”CON(R8)â€”, â€”OC(O)N(R8)â€”, â€”CSN(R8)â€”, â€”N(R8)C(O)â€”, â€”N(R8)C(O)Oâ€”, â€”N(R8)CSâ€”, â€”S(O)2N(R8)â€”, â€”N(R8)S(O)3â€”, â€”N(R8)CSN(R8)â€”, and â€”N(R8)SO2N(R8)â€” (wherein R8 may be the same or different and is a hydrogen atom or an optionally substituted straight or branched alkyl group); r and s is each zero or an integer 1; R2 and R3, which may be the same or different, is each a hydrogen or halogen atom, a hydroxyl or nitro group, or a straight or branched alkyl, haloalkyl, alkoxy, or haloalkoxy group; Alk2 is a straight or branched alkylene chain; m is zero or an integer 1; R4 is a hydrogen atom or a methyl group; R5 is a group â€”L2(CH2)tR6 in which L2 is a â€”N(R7)COâ€” (where R7 is a hydrogen atom or a straight or branched alkyl group) or â€”N(R7)CSâ€” group, t is zero or the integer 1, and R6 is an optionally substituted pyrrolidinyl, thiazolidinyl, phenyl or pyridyl group; R is a carboxylic acid; provided that: (1) when R1 is phenyl, r and s are each zero, R2 and R3 are hydrogen, Alk2 is CH2, m is 1, R4 is hydrogen, R is CO2H, and L2 is â€”N(CH3)C(O)â€”, then R5 is other than substituted phenyl; and (2) when r is zero and s is 1, L1 is other than â€”CON(R8)â€”; or a pharmaceutically acceptable salt, solvate, or hydrate thereof.