Patent ID: 6171824
Filing Date: 2001-01-09
Classification: A61K,C07K

Abstract:
A hybrid cytokine polypeptide comprising: 1) four .alpha.-helical sequences, the .alpha.-helical sequences selected from cytokine .alpha.-helical sequences, the cytokine being selected from the group consisting of leukemia inhibitory factor (L), granulocyte colony stimulating factor (G), interleukin-6 (I), interleukin-11 (E), ciliary neurotrophic factor (C), and oncostatin-M (O); and 2) three linking sequences, the linking sequences selected from at least a portion of one or more linking sequences from any of the foregoing cytokines, wherein at least one of the four .alpha.-helical sequences is derived from a different cytokine than at least one other of the four .alpha.-helical sequences.