Patent ID: 6613909
Filing Date: 2003-09-02
Classification: C07D

Abstract:
A process of making a compound formula (C):said process comprising: reacting a compound of the formula(B) with RxCOCl or (RxCO)2O and a metal iodide in a suitable solvent at a temperature of 25Â° C. to 150Â° C. to produce a compound of the formula(C); â€ƒwherein Rx is chosen from â€”C1-7 alkyl, â€”CF1-3 and â€”CCl1-3; Xa is chosen from Br and Cl and Xa is attached via the 5 ring position; Xc is I; W is CR3 or N, wherein R3 is chosen from hydrogen, C1-5alkyl, C1-5alkoxy, arylC0-5alkyl and â€”COR4 wherein R4 is chosen from C1-5alkyl, C1-5alkoxy, arylC0-5alkyl and amino which is optionally independently or di-substituted by C1-5alkyl, and arylC0-5alkyl; and L is Br.