Patent ID: 6074669
Filing Date: 2000-06-13
Classification: A61K

Abstract:
A once-a-day controlled release pharmaceutical composition in the form of a matrix of well-mixed components, comprising: (a) about 30 to about 90% by weight of a hydrophilic polymer, (b) about 0.5 to about 30% by weight of a pH dependent enteric polymer, and (c) about 2.5 to about 60% by weight of diltiazem or a pharmaceutically acceptable salt or ester thereof, wherein the hydrophilic polymer to enteric polymer is in the range of about 1:1 to about 15:1, wherein the hydrophilic polymer and the enteric polymer comprise about 35 to about 97.5% by weight of said composition, and wherein the hydrophilic polymer comprises a mixture of about 10% to about 70% by weight of hydroxypropyl methylcellulose and about 5% to about 50% by weight of hydroxypropylcellulose, of said composition.