Patent ID: 8992946
Filing Date: 2015-03-31
Classification: A61L,A61P

Abstract:
1. A tissue regeneration- or graft-promoting structure for promoting tissue regeneration, for promoting tissue repair, or for promoting or facilitating a tissue graft or a combination thereof, by covering an area of damaged, injured, diseased, wounded, removed or missing tissue of a body of a subject, comprising a resorbable multi-layer structure which includes a purified collagen barrier sheet material derived from natural collagen-containing tissue, wherein the barrier sheet material comprises a barrier layer including an outer smooth barrier face and further includes a fibrous face opposite said smooth barrier face, wherein said multi-layer structure further comprises a matrix layer comprising collagen sponge material adjacent to said fibrous face, wherein said matrix layer of collagen sponge material is adapted to be positioned adjacent said area, and said multi-layer structure is adapted by crosslinking so that said matrix layer is resorbed by the body of a subject within about 2-5 weeks after said covering and said collagen barrier sheet material is resorbed by the body of a subject within about 6-11 weeks after said covering, wherein said multi-layer structure is adapted by a method selected from application of UV radiation by a UV lamp of about 10-20 W at about 15-45 cm distance from the collagen sponge layer surface of the membrane for about 2-4 hours, cross-linking by dehydrothermal treatment under vacuum at <200 mbar and 100° Celsius for 24 hours, cross-linking with EDC in an aqueous solution of about 0.1-0.6 g EDC per about 0.3-2 g collagen sponge matrix, using cross-linking agents such as hyaluronan, hexethylendiisocyamate, N-hydroxysuccinimide (NHS) or gloxal, and wherein said matrix layer comprises collagen material consisting essentially of porcine collagen sponge from porcine skin.