Patent ID: 6689888
Filing Date: 2004-02-10
Classification: A61P,C07D

Abstract:
A process for preparing a compound of the structural formula comprising the steps of(a) reducing an &agr;-bromoketone derivative of the structural formula or an acid addition salt thereof, to form an (R)-bromoalcohol derivative of the structural formula (b) protecting said (R)-bromoalcohol derivative of Step (a) to form an O-protected derivative of the structural formula (c) condensing said O-protected derivative of Step (b) with an amine of the structural formula to produce an O-protected derivative of the structural formula (d) deprotecting said O-protected derivative of Step (c) to form said compound of said structural formula wherein:HET is a heterocyclic moiety selected from the group consisting of oxazolyl, pyrazolyl, and thiazolyl; and P is an O-protecting moiety selected from the group consisting of â€”SiR1R2R3, â€”CH2Ph, â€”CH2(p-CH3OPh), â€”CH(OCH2CH3)CH3, and where R1, R2, and R3are each independently (C1-C6)alkyl, or phenyl.