Patent ID: 8389713
Filing Date: 2013-03-05
Classification: A61K,C08B

Abstract:
1. A process for producing a polysaccharide pseudo-sponge, comprising: irradiating light to a solution of a photoreactive polysaccharide having a photoreactive group to obtain a polysaccharide gel having a shape-retention property, freezing or freeze-drying the obtained polysaccharide gel, and then irradiating light to the resultant frozen or freeze-dried polysaccharide gel, wherein the polysaccharide pseudo-sponge exhibits a low swelling property (I) and an enzymatic degradation time (II) which satisfy the following properties: (I) a swelling ratio of not more than 125% as calculated from the values measured by immersing a test specimen having a thickness of 1 mm, a length of 10 mm and a width of 10 mm, and a solvent content of 96% by weight, in water for injection at room temperature for 1 hour, according to the following formula: wherein S1 represents an area of the test specimen before the immersion, and S2 is an area of the test specimen after the immersion, in which the area is calculated from the length and width of the test specimen; and (II) an enzymatic degradation time of the polysaccharide pseudo-sponge is not more than 1300 minute as measured by subjecting a test specimen having a thickness of 1 mm, a length of 20 mm and a width of 10 mm, and a solvent content of 96% by weight, to a polysaccharide degrading enzyme in a reaction mixture containing 1 mL of a 5 mmol/L phosphate buffered saline, 0.2 mL of a 1 mol/L acetate buffer solution and 0.2 mL of a 5TRU (Turbidity Reducing Unit)/mL the enzyme solution at 50° C.