Patent ID: 6506901
Filing Date: 2003-01-14
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I having the structure wherein,A is â€”OCH2â€”; R is (a) aryl optionally substituted with R2, R3, R4, R5, or R6; R1 is: (b) aryl optionally substituted with R9, R10, or R11; R2, R3, R4, R5, and R6 are each, independently, alkyl of 1-6 carbon atoms, hydroxy, alkoxy of 1-6 carbon atoms, arylalkoxy having 1-6 carbon atoms in the alkyl moiety, halogen, â€”NHSO2R7, â€”CO2R8, or â€”CONH2; R7 and R8 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or arylalkyl having 1-6 carbon atoms in the alkyl moiety; Z is â€”SO2â€”; R9, R10, and R11 are each, independently: R12 is hydrogen, alkyl of 1-6 carbon atoms, or aryl optionally substituted with R15, arylalkyl having 1-6 carbon atoms in the alkyl moiety and the aryl moiety optionally substituted with R15 R14 is hydrogen, alkyl of 1-6 carbon atoms, or aryl optionally substituted by R16; R15 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, arylalkyl having 1-6 carbon atoms in the alkyl moiety, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy having 1-6 carbon atoms in the alkyl moiety, hydroxy, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, arylamino, halogen, alkylthio of 1-6 carbon atoms, trifluoromethyl, â€”(CH2)nâ€”NHR14, â€”OCH2(CH2)nCO2R7, â€”(CH2)nâ€”CO2R7, â€”COR7, â€”SO2R13, â€”(CH2)nNHCOR14, â€”CN, or NO2; R16 is alkyl of 1-6 carbon atoms, arylalkyl having 1-6 carbon atoms in the alkyl moiety, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy having 1-6 carbon atoms in the alkyl moiety, hydroxy, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, arylamino, halogen, alkylthio of 1-6 carbon atoms, â€”CO2R7, â€”COR7, â€”CN, â€”NO2, or trifluoromethyl; n=0-6; or a pharmaceutically acceptable salt thereof.