Patent ID: 6814870
Filing Date: 2004-11-09
Classification: B01D,B01J,G01N,H01J

Abstract:
A method for analysis comprising:providing an electrospray device comprising: a substrate having: a) an injection surface, b) an ejection surface opposing the injection surface, wherein the substrate has at least one spray unit which comprises: an entrance orifice on the injection surface, an exit orifice on the ejection surface, a channel extending through the substrate between the entrance orifice and the exit orifice, and a recess extending into the ejection surface and surrounding the exit orifice, c) polymerized separation material comprising affinity chromatographic adsorbent, wherein the separation material is associated with said electrospray device at a location suitable to effect chromatographic separation of analytes passing through said electrospray device, and d) an electric field generating source positioned to define an electric field surrounding at least one exit orifice; and selectively immobilizing affinity ligands on the polymerized separation material of the device.