Patent ID: 9081017
Filing Date: 2015-07-14
Classification: A61K,A61P,G01N

Abstract:
1. A method of identifying and/or obtaining a compound useful in treating a disease condition selected from the group consisting of acute renal transplant rejection, acute tubular necrosis, coronary artery disease, cardiac allograft rejection, peripheral vascular/arterial disease and ischemia, comprising: contacting a test compound with a tumor necrosis factor receptor 1 (TNFR1) polypeptide and a tumor necrosis factor receptor 2 (TNFR2) polypeptide wherein the test compound is an antibody or an antibody fragment; determining activation of said TNFR1 and TNFR2 polypeptides, wherein the activation of said TNFR1 and TNFR2 polypeptides is determined in kidney tissue culture; and (1) identifying a test compound which activates the TNFR2 polypeptide and binds but does not activate the TNFR1 polypeptide or a test compound which binds to the TNFR1 polypeptide without activating the TNFR1 polypeptide as a compound for useful in the treatment of a disease condition selected from acute renal transplant rejection, acute tubular necrosis, coronary artery disease, cardiac allograft rejection, and peripheral vascular/arterial disease; or (2) identifying a test compound which activates the TNFR2 polypeptide and binds but does not activate the TNFR1 polypeptide as a compound useful in the treatment of ischemia.