Patent ID: 7208602
Filing Date: 2007-04-24
Classification: A61P,C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: (A) R (B) R (C) Each R (D) Each R (E) R (F) X is selected from the group consisting of: (G) Y is selected from the group consisting of: wherein the aryl moiety in said substituted groups (12), (14), (15) and (18) of said Y group, and the heteroaryl moiety in said substituted groups (13), (16), and (17) of said Y group, are substituted with one or more (e.g., 1 to 3) substituents independently selected from the group consisting of: (a) halo; (b) —CF (c) —OH; (d) —Oalkyl; (e) —OCF (f) —CN; (g) —NH (h) —CO (i) —C(O)NR (j) —(C (k) —NR (l) —NR (m) —NR (n) —NR or Y is selected from the group consisting of: (H) R (I) Each R (J) Each R (K) Each R (L) R wherein the aryl moiety in said substituted groups (2), (13), (14) and (16) of said R 11 group, and the heteroaryl moiety in said substituted groups (12) and (15) of said R 11 group, are substituted with one or more (e.g., 1 to 3) substituents independently selected from the group consisting of: (a) halo; (b) —CF (c) —OH; (d) —Oalkyl; (e) —OCF (f) —CN; (g) —NH (h) —CO (i) —CONR (j) —(C (k) —NR (l) —NR (m) —NR (n) —NR (M) m is 0 to 3, and n is 0 to 3, o is 0–3, such that m+n+o is 1, 2, 3 or 4; (N) p is 0 to 4; (O) r is 0 to 4; (P) s is 0 to 3; and (Q) Z is selected from the group consisting of: wherein said substituted heterocycloalkyl moiety of substituents (2), (14), (16), (24), (26) and (27) of group Z, and said substituted cycloalkyl moiety of substituents (7), (9), (20) and (22) of group Z, and said substituted aryl moiety of substituent (11) of group Z, and said substituted heteroaryl moiety of substituent (18) of group Z, are substituted with 1 to 3 groups independently selected from the group consisting of: (a) alkyl; (b) —OH; (c) —Oalkyl; (d) —O(CO)alkyl; (e) —O(CO)aryl; (f) —NH (g) —NH(alkyl); (h) —N(alkyl) (i) —NH(CO)alkyl; (j) —N(alkyl)(CO)alkyl; (k) —NH(CO)aryl; (l) —N(alkyl)(CO)aryl; (m) —COalkyl; (n) —COaryl; (o) —CONH (p) —CONH(alkyl); (q) —CON(alkyl) (r) —COOalkyl; (s) -alkylene-C(O)Oalkyl; (t) piperidinyl; (u) pyrrolidinyl; (v) 1,1-ethylenedioxy; (w) aryl; (x) heteroaryl; and (y) —O—CH