Patent ID: 6656698
Filing Date: 2003-12-02
Classification: A61K,C07K,C12N,C12Q

Abstract:
A method for identifying a compound which modulates the activity of a polypeptide selected from the group consisting of:(a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2; b) a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO:2, wherein the fragment has a kinase protein activity and comprises at least 75 contiguous amino acids of SEQ ID NO:2; c) a polypeptide encoded by the nucleic acid sequence of SEQ ID NO:1; and d) a variant of the polypeptide comprising the amino acid sequence of SEQ ID NO:2, said variant having a kinase protein activity, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:1, nucleotides 191-1156 of SEQ ID NO:1, or a complement thereof under stringent conditions, said stringent conditions comprising hybridization in 6Ã—SSC at 42Â° C., followed by washing with 1Ã—SSC at 55Â° C.; comprising e) combining the polypeptide or a cell expressing the polypeptide with a test compound; and f) determining the effect of the test compound on the activity of the polypeptide, to thereby identify a compound which modulates the activity of the polypeptide.