Patent ID: 6664367
Filing Date: 2003-12-16
Classification: C07K,Y10S

Abstract:
A cyclic peptide analog having the following general formula: wherein (AA1)k, (AA2)l, and (AA3)m are &agr;-amino acids in the peptide and the bonds connecting (AA1)k, Q, (AA2)l, Z, and (AA3)m are conventional peptide bonds; k, l, and m are the number of &agr;-amino acids and may range from 0 to 15 with the proviso that at least two of k, l, and m are greater the zero; W and X are â€”Sâ€” or â€”CHR1â€”, such that when W is â€”Sâ€”, then X is â€”CHR1â€” and when W is â€”CHR1â€”, then X is â€”Sâ€”; R1 is â€”(CH2)nâ€”Y; n is from 0 to 10; Y is a reactive functional group capable of being coupled to a bifunctional effector molecule; and Q and Z may be the same or different and have the following general structure: wherein p may range from 0 to 3 and R2 is H, alkyl, aryl, hydroxyalkyl, alkoxyalkyl, and carboxyl wherein the carbon containing portions contain from 1 to 10 carbon atoms or the side chain portion of naturally occurring &agr;-amino acids.