Patent ID: 6797521
Filing Date: 2004-09-28
Classification: A61B,A61K,C07F,C09K,G01N,G02B

Abstract:
A cobalamin having the general formula where R1 is CN, OH, OH2, CH3, 5â€²-(5â€²-deoxyadenosyl) or (CH2)pNHC(&boxH;S)Y; R2, R3, R4, R5, R6, and R7 are CONH2; R8 is CH2OH or CH2O(C&boxH;O)XmY; R9 is OH or O(C&boxH;O)XmY; X is a linker having the formula NH(CH2)nNHO(C&boxH;O) or NHâ€”(CH2)nâ€”NH; Y is a fluorophore, a phosphorophore, or a chemiluminescent chromophore; m is 0 or 1, n is 0-50 and p is 2-10, with the proviso that at least one of R1, R8 and R9 groups has Y, wherein said cobalamin fluoresces, phosphoresces or luminesces when illuminated with ultraviolet, visible, or infrared light without cleavage of Y from the cobalamin.