Patent ID: 6027921
Filing Date: 2000-02-22
Classification: A61K,A61P,C07K,C12N

Abstract:
A chimeric protein comprising a functional domain and a carrier domain, wherein the functional domain comprises a ligand-binding domain of a first receptor selected from the group consisting of a low density lipoprotein (LDL) receptor, an acetylated LDL receptor, a tumor necrosis factor .alpha. receptor, a transforming growth factor .beta. receptor, a cytokine receptor, an immunoglobulin F.sub.c receptor, a hormone receptor, a glucose receptor, a glycolipid receptor, and a glycosaminoglycan receptor; and the carrier domain comprises a glycosylated or unglycosylated amino acid sequence which binds a mammalian cell surface receptor other than the first receptor, wherein (a) the amino acid sequence is from a protein other than the first receptor, and (b) the mammalian cell surface receptor is selected from the group consisting of low density lipoprotein receptors (LDLR), transferrin receptors, asialoglycoprotein receptors, adenovirus receptors, retrovirus receptors, CD4, lipoprotein (a) receptors, LDLR-like protein (LRP) receptors, acetylated LDL receptors, mannose receptors and mannose-6-phosphate receptors; provided that, when the chimeric protein binds to the mammalian cell surface receptor on a cell, the mammalian cell surface receptor transports the chimeric protein into the cell.