Patent ID: 8951595
Filing Date: 2015-02-10
Classification: A61F,A61L,A61M

Abstract:
1. A method of coating an outer surface of a balloon of a balloon catheter, the method comprising: selecting a first therapeutic agent; selecting a first excipient; modifying the first excipient, wherein modifying the first excipient comprises modification to two or more properties of the first excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; selecting a second therapeutic agent; selecting a second excipient; modifying the second excipient, wherein modifying the second excipient comprises modification to at least one property of the excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; blending the first therapeutic agent and the first excipient and the second therapeutic agent and the second excipient to define a coating; and applying the coating to the outer surface of the balloon, wherein the first therapeutic agent and the first excipient have a weight ratio of about 20:1 to about 1:20, and further wherein the coating enables transfer of a therapeutically effective amount of the therapeutic agent to a body lumen within less than one hour.