Patent ID: 6716840
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound of formula I whereinX and Y are independently selected from the group consisting of CH2, C&boxH;O, and C&boxH;S; W is selected from the group consisting of L is selected from the group consisting of O, C(O), OC(O), and a covalent bond; Z1, Z2, and Z3 are CR8; R1 is selected from the group consisting of H, and substituted and unsubstituted arylalkyl, aryl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, and alkyl groups; R2 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, elkynyl, cycloalkylalkyl, aryl, and arylalkyl groups; R3 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, arylalkyl, and cycloalkylalkyl groups, or R2 and R3 may join together to form a ring containing at least two N atoms; R4 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, and cycloalkylalkyl groups, or R and Râ€² may join together to form a ring containing at least two N atoms; R5 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, and cycloalkylalkyl groups, or R4 and R5, together with the nitrogen to which they are bound, form a substituted or unsubstituted heterocyclyl or heteroaryl group, or R3 and R5 may join together to form a ring containing at least two N atoms; R8 is selected from the group consisting of H, Cl, I, F, Br, OH, NH2, CN, NO2, and substituted and unsubstituted alkoxy, amino, alkyl, alkenyl, alkynyl, alkylamino, dialkylamino, cycloalkyl, aminocarbonyl, alkyisminocarbonyl, dialkylaminocarbonyl, cycloalkylaminocarbonyl, and arylaminocarbonyl groups; and R9 prodrugs thereof, pharmaceutically acceptable salts thereof, stereolsomers thereof, tautomers thereof, hydrates thereof, hydrides thereof, or solvates thereof.