Patent ID: 8076353
Filing Date: 2011-12-13
Classification: A61K,A61P,C12Q

Abstract:
1. A method for treating a disease associated with elevated levels of VEGF in a subject in need thereof comprising administering a therapeutically effective amount of a compound of Formula (IV): or a pharmaceutically acceptable salt, racemate or stereoisomer thereof, wherein, X is hydrogen; C R R R R R R wherein the compound reduces VEGF levels as measured by an ELISA assay or a quantitative immunofluorescence assay, or reduces VEGF levels in HT1080 clones stably expressing epitope-tagged VEGF with a 5′-UTR; and wherein the disease is solid tumor cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, atherosclerosis, chronic inflammation, a chronic inflammation-related disease or disorder, obesity, or exudative macular degeneration.