Patent ID: 6720342
Filing Date: 2004-04-13
Classification: A61P,C07D

Abstract:
A compound of formula I or the quaternized form thereof: whereinW is oxygen or sulphur; R is â€”OR4, â€”SR4, â€”SOR4, â€”SO2R4, or R4, wherein R4 is propynyl substituted with phenoxy, wherein the phenoxy is optionally substituted with one or more halogen(s), â€”OH, â€”NO2, â€”CN, C1-4-alkyl, C1-4-alkylthio, C1-4-alkoxy, â€”SCF3, â€”OCF3, â€”CF3, â€”CONH2 or â€”CSNH2; r is 0, 1 or 2; and G is an azabicyclic ring system which is: wherein the thiadiazole ring is attached at any appropriate position;R1 and R2 independently are hydrogen, â€”OH, &boxH;O, C1-15-alkyl, C2-15-alkenyl, C2-15-alkynyl, C1-10-alkoxy, and C1-5-alkyl substituted with one or more halogen(s), â€”OH, â€”COR8, â€”CH2OH, â€”NH2, carboxy and phenyl; R8 is hydrogen, or C1-6-alkyl; Â· Â· Â· is a single or double bond; or a pharmaceutically acceptable salt or solvate thereof.