Patent ID: 8609731
Filing Date: 2013-12-17
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula I wherein: R1 and R2 taken together with the nitrogen atom to which they are attached form a 4- to 10-membered mono-, bi- or spirocyclic ring which, apart from the nitrogen atom, may include from 0 to 3 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, wherein the ring is optionally substituted by F, Cl, Br, CF R18, R19, R20, R21, R22, R23 and R24, are each independently H or (C or R23 and R24 taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms selected from the group consisting of NH, N—(C L1 is C(R34)(R35) or C(R36)(R37)C(R38)(R39); optionally, R1 may be joined to one of the R34, R35, R36, R37, R38 or R39 radicals, so as to form a 5-6-membered ring; R34, R35, R36, R37, R38 and R39 are each independently H or (C R3, R4 and R5 are each independently H, F, Cl, Br, I, OH, CF R40, R41 and R42 are each independently H or (C or R40 and R41 taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatoms selected from the group consisting of NH, N—(C X is C(R43)(R43′); R6, R6′, R7, R7′, R43 and R43′ are each independently H, F, (C or R6 and R6′, or R43 and R43′ together are oxo; R8 is H or (C L2 is a bond or C(R44)(R45); R44 and R45 are each independently H or (C A is a 5-6-membered aromatic ring that may include up to two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is optionally substituted by one or more of substituents selected from H, F, Cl, Br, I, OH, CF provided that when L2 is a bond, then C(O)NR8 may be joined to an ortho substituent of A via a bridge containing one or two elements from the group of carbon and nitrogen, so as to form a 9- to 10-membered bicyclic ring overall; R54, R55, R56, R57, R58, R59, and R60 are each independently H or (C or R54 and R55, and R56 and R57 each independently taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatom from the group of NH, N—(C L3 is C(R62)(R63)O, and B is a 4- to 10-membered mono-, bi- or spirocyclic non-aromatic ring that includes from 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, wherein the non-aromatic ring is optionally substituted by one or more substituents selected from F, CF R62, R63, and R64 are each independently H or (C or a physiologically compatible salt thereof.