Patent ID: 9089513
Filing Date: 2015-07-28
Classification: A61K,A61P,C07K,C08B,C08L,Y02A

Abstract:
1. A method of detecting a tumor in a subject, the method comprising: contacting a biological sample obtained from a subject suspected of having cancer with an antibody that specifically binds a de-N-acetylated sialic acid (deNAc SA) epitope on an extracellularly accessible surface of a cancerous cell present in the subject, said deNAc SA epitope minimally defined by a dimmer containing at least one de-N-acetylated sialic acid residue having a free amine adjacent an N-acylated sialic acid residue or a sialic acid derivative residue, said isolated antibody separated from cationic or other charged contaminants, said contacting being under conditions suitable for specific binding of the antibody to a deNAc SA epitope in the biological sample; wherein the presence or absence of binding of the antibody is indicative of the presence or absence of cancerous cells having a cell surface deNAc SA epitope in the subject.