Patent ID: 6258795
Filing Date: 2001-07-10
Classification: A61K,C07H

Abstract:
An acyl derivative of uridine having the formula (II) ##STR4##wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl radical of(a) an unbranched fatty acid with 5 to 22 carbon atoms,(b) an amino acid selected from the group consisting of glycine, L-forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cystine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,(c) a dicarboxylic acid of 3 to 22 carbon atoms, or(d) a carboxylic acid selected from one or more of the group consisting of glycolic acid, pyruvic acid, lactic acid, enolpyruvic acid, lipoic acid, pantothenic acid, acetoacetic acid, p-aminobenzoic acid, betahydroxybutyric acid, orotic acid, and creatine,provided that at least one of said substituents R.sub.1, R.sub.2, and R.sub.3 is not hydrogen, and further provided that if any of said substituents R.sub.1, R.sub.2, and R.sub.3 is hydrogen and if said remaining substituents are acyl radicals of a straight chain fatty acid, then said straight chain fatty acid has 8 to 22 carbon atoms, or a pharmaceutically acceptable salt thereof.