Patent ID: 6576653
Filing Date: 2003-06-10
Classification: A61P,C07D

Abstract:
A compound of Formula I: a stereoisomer, Pharmaceutically acceptable salt or prodrug thereof, or a Pharmaceutically acceptable salt of the prodrug, wherein Q is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; Z is C or OH and X is O; X1 is NRa, â€”CH2â€”, O or S; each â€”â€”â€”â€” is independently a bond or is absent, provided that both â€”â€”â€”â€” are not simultaneously bonds; R1 is hydrogen, halogen, â€”OC1-C8alkyl, SC1-C8alkyl, â€”C1-C8alkyl, â€”CF3, â€”NH2, â€”NHC1-C8alkyl, â€”N(C1-C8alkyl)2, â€”NO2, â€”CN, â€”CO2H, â€”CO2C1-C8alkyl, â€”C2-C8alkenyl, or â€”C2-C8alkynyl; each Ra and Rb is independently hydrogen or â€”C1-C8alkyl; R2 and R3 are independently hydrogen, halogen, â€”C1-C8alkyl, â€”CN, â€”Câ‰¡Câ€”Si(CH3)3, â€”OC1-C8alkyl, â€”SC1-C8alkyl, â€”CF3, â€”NH2, â€”NHC1-C8alkyl, â€”N(C1-C8alkyl)2, â€”NO2, â€”CO2H, â€”CO2C1-C8alkyl, â€”C2-C8alkenyl, or â€”C2-C8alkynyl; R4 is â€”C(&boxH;O)â€”A; A is â€”NRdRd, â€”NRaCH2CH2CORa, each Rdis independently hydrogen, C1-C8alkyl, C1-C8alkoxy, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; each Rc is independently hydrogen, â€”C(&boxH;O)ORa, â€”ORa, â€”SRa, or â€”NRaRa; and each n is independently 1-3.