Patent ID: 6013471
Filing Date: 2000-01-11
Classification: A61K,C07K,C12N

Abstract:
An isolated nucleic acid molecule encoding a variant pre-pro hK2 polypeptide, a variant pro hK2 polypeptide, or a variant mature hK2 polypeptide, wherein the variant hK2 polypeptide has at least one amino acid at amino acid positions 1-14, 27-40, 57-152 or 168-237 substituted relative to SEQ ID NO: 16, and 100% sequence identity to acid sequence corresponding to SEQ ID NO: 16 at amino acid positions 15-26, 41-56 and 153-167 of SEQ ID NO: 16, wherein the variant polypeptide binds to an antibody that binds to mature hK2 but not to PSA.