Patent ID: 8536147
Filing Date: 2013-09-17
Classification: A61K,A61P,C07D,C07F,C07K,C08F,C12N

Abstract:
1. An antisense conjugate, comprising (a) an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, wherein the oligonucleotide contains between 10-20 bases and a targeting sequence of at least 10 contiguous bases complementary to a target sequence containing or within 20 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes acyl carrier protein (acpP), wherein the target sequence is the (b) a carrier peptide represented by the formula (RAhxR)