Patent ID: 6818634
Filing Date: 2004-11-16
Classification: A61P,C07C,C07D,C07J

Abstract:
A substituted tetracycline compound, wherein said compound is of the formula: wherein:X is CHC(R13Yâ€²Y), CR6â€²R6, S, NR6, or O; R2 is hydrogen, alkyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; R4 and R4â€² are each hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; R2â€², R3, R10, R11 and R12 are each hydrogen or a pro-drug moiety; R5 is hydrogen, hydroxyl, or a prodrug moiety; R6, R6â€², and R8 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, or halogen; R7 is hydrogen, dialkylamino, or heteroaryl-amino; R13 is hydrogen, hydroxy, alkyl; alkenyl; alkynyl; alkoxy; alkylthio; alkylsulfinyl; alkylsulfonyl; alkylamino; or an arylalkyl; Yâ€² nd Y are each independently hydrogen; halogen; hydroxyl; cyano, sulfhydryl; amino; alkyl; alkenyl; alkynyl; alkoxy; alkylthio; alkylsulfinyl; alkylsulfonyl; alkylamino; or an arylalkyl; R9 is hydrogen, or heteroaryl-amino; and pharmaceutically acceptable salts thereof, provided that R9 is not hydrogen when R7 is hydrogen or dialkylamino.