Patent ID: 6831154
Filing Date: 2004-12-14
Classification: C07K

Abstract:
A method for selecting modulators of an interaction between a first protein and a second protein,(a) said first protein being selected from the group consisting of (i) MAP17 (SEQ ID NO:1), (ii) a MAP17 homologue having an amino acid sequence at least 90% identity to that of MAP17 (SEQ ID NO:1) and capable of interacting with SCAMP2 (SEQ ID NO:2), (iii) a MAP17 fragment of MAP17 (SEQ ID NO:1) capable of interacting with SCAMP2 (SEQ ID NO:2), and (iv) a fusion protein containing MAP17 (SEQ ID NO:1), said MAP17 homologue or said MAP17 fragment; and (b) said second protein being selected from the group consisting of (1) SCAMP2 (SEQ ID NO:2), (2) a SCAMP2 homologue having an amino acid sequence at least 90% identity to that of SCAMP2 (SEQ ID NO:2) and capable of interacting with MAP17 (SEQ ID NO:1), (3) a SCAMP2 fragment of SCAMP2 (SEQ ID NO:2) capable of interacting with MAP17 (SEQ ID NO:1), and (4) a fusion protein containing SCAMP2 (SEQ ID NO:2), said SCAMP2 homologue or said SCAMP2 fragment, said method comprising: contacting said first protein with said second protein in the presence of a test compound; and detecting the interaction between said first protein and said second protein; and selecting a test compound that modulates the interaction between a first protein and a second protein.