Patent ID: 7419967
Filing Date: 2008-09-02
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A pharmaceutical composition comprising a compound of formula (I): wherein: A is selected from H; Ht; —R each R each Ht is independently selected from C each R B, when present, is —N(R each x is independently 0 or 1; each R each n is independently 1 or 2; G, when present, is selected from H, R when G is not present, the nitrogen to which G is attached is bound directly to the R D is selected from Q; C each Q is independently selected from a 3-7 membered saturated, partially saturated or unsaturated carbocyclic ring system; or a 5-7 membered saturated, partially saturated or unsaturated heterocyclic ring containing one or more heteroatoms selected from O, N, S, S(O) D′ is selected from —OR E is selected from Ht; O-Ht; Ht-Ht; —O—R each R each R wherein each M is independently selected from H, Li, Na, K, Mg, Ca, Ba, —N(R M′ is H, C Z is O, S, N(R Y is P or S; X is O or S; R R R R wherein each R or a pharmaceutically acceptable derivative thereof; an additional antiviral agent selected from the group consisting of (1 alpha, 2 beta, 3 alpha)-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine [(−)BHCG, SQ-34514], oxetanocin-G (3,4-bis-(hydroxymethyl)-2-oxetanosyl]guanine), acyclovir, valaciclovir, famciclovir, ganciclovir, penciclovir, (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (HPMPC), 2-acetylpyridine 5-[(2-chloroanilino)thiocarbonyl)thiocarbonohydrazone, 3′azido-3′-deoxythymidine, hydroxyurea, 2′,3′-dideoxycytidine, 2′,3′-dideoxyadenosine, 2′,3′-dideoxyinosine, 2′,3′-didehydrothymidine, agenerase, indinavir, ritonavir, nelfinavir, [3S-[3R*(1R*,2S*)]]-[3[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-tetrahydro-3-furanyl ester (141W94), (−)-cis-1-(2hydroxymethyl)-1,3-oxathiolane 5yl)-cytosine (lamivudine), cis-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-fluorocytosine (FTC), 3′-deoxy-3′-fluorothymidine, 5-chloro-2′,3′-dideoxy-3′-fluorouridine, (−)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2cyclopentene-1-methanol, ribavirin, 9-[4-hydroxy-2(hydroxymethyl)but-1-yl]-guanine (H2G), 7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2-(H)one (Ro5-3335), 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine (Ro24-7429), interferons, renal excretion inhibitors, nucleoside transport inhibitors, pentoxifylline, N-acetylcysteine (NAC), Procysteine, α-trichosanthin, phosphonoformic acid, interleukin II, thymosin, granulocyte macrophage colony stimulating factors, erythropoetin, soluble CD