Patent ID: 6452008
Filing Date: 2002-09-17
Classification: C07D

Abstract:
A process for preparing a pyridone derivative of the formula (4): wherein R1 is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, a cycloalkyl group, or a substituted cycloalkyl group; Y1 is a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, or a substituted aromatic group; Y2 and Y3 are independently a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, a trifluoromethyl group, a nitro group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, a substituted aromatic group, or Y2 and Y3 may combine each other together with the carbon atoms to which they bond, and form a substituted or unsubstituted pyridine ring; and L is an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, or a substituted aromatic group,which comprises reacting a compound of the formula (5): wherein R1, Y1, Y2 and Y3 are as defined above, with a compound of the formula (6):XCO2R2â€ƒâ€ƒ(6) wherein R2 is a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted phenyl group; and X is a chorine atom or a bromine atom, to give a compound of the formula (7): wherein R1, R2, Y1, Y2 are Y3 are as defined above, followed by reacting the compound (7) with a compound of the formula (3):Lâ€”NH2â€ƒâ€ƒ(3) wherein L is as defined above.