Patent ID: 6890905
Filing Date: 2005-05-10
Classification: A61K

Abstract:
1. A method for improving for improving β-cell capacity to secrete insulin in response to increased glucose levels comprising administering a therapeutically effective dose of a DP IV-inhibitor thereby increasing the availability of islet cell growth hormone to pancreatic cells wherein said islet cell growth hormone circulates at a level which is substantially unresponsive to acute changes in glucose level said DP IV-inhibitor comprises a dineptide compound selected from the group consisting of N-valyl prolyl, O-benzoyl hydroxylamine, alanyl pyrrolidine, L-allo-isoleucyl thiazolidine, L-allo-isoleucyl pyrrolidine, L-threo-isoleucyl thiazolidine, L-threo-isoleucyl pyrrolidine, asparaginyl pyrrolidine, asparaainyl thiazolidine, asparagyl pyrrolidine, asparagyl thiazolidine, glutamyl pyrrolidine, glutamyl thiazolidine, glutaminyl pyrrolidine, glutaminyl thiazolidine, histidyl pyrrolidine, histidyl thiazolidine, isoleucyl azitidine, valyl pyrrolidine and valyl thiazolidine, or a pharmaceutical acceptable salt thereof.