Patent ID: 7994219
Filing Date: 2011-08-09
Classification: A61K,A61P

Abstract:
1. A method to treat sepsis in a subject, comprising the step of administering to a subject infected with sepsis a therapeutically effective amount of a lipoxin analog according to formula I or II, wherein formula I is: wherein R and R wherein X is R wherein R (i) a hydrogen atom; (ii) an alkyl of 1 to 8 carbons atoms, inclusive, which can be straight chain or branched; (iii) a cycloalkyl of 3 to 10 carbon atoms, inclusive; (iv) an aralkyl of 7 to 12 carbon atoms; (v) phenyl; (vi) substituted phenyl (vii) a detectable label molecule; or (viii) a straight or branched chain alkenyl of 2 to 8 carbon atoms, inclusive; wherein Q wherein Q wherein one of R (a) a hydrogen atom; (b) an alkyl of 1 to 8 carbon atoms, inclusive, which can be straight chain or branched; (c) a cycloalkyl of 3 to 6 carbon atoms, inclusive; (d) an alkenyl of 2 to 8 carbon atoms, inclusive, which can be straight chain or branched; or (e) R wherein Q wherein R wherein R (a) a hydrogen atom; (b) an alkyl of 1 to 6 carbon atoms, inclusive, which can be straight chain or branched; wherein Y (a) a hydrogen atom (b) CH where a+b=3, a=0 to 3, b=0 to 3; and each Z, independently, is a cyano, a nitro, or a halogen atom; (c) an alkyl of 2 to 4 carbon atoms, inclusive, straight chain or branched; or (d) an alkoxy of 1 to 4 carbon atoms, inclusive; or Y (a) ═NH; or (b) ═O; wherein R (a) an alkyl of 1 to 9 carbon atoms which can be straight chain or branched; (b) —(CH wherein n=0 to 4 and R (i) a cycloalkyl of 3 to 10 carbon atoms, inclusive; (ii) a phenyl; or (iii) substituted phenyl (c) R wherein Q wherein R wherein R (d) —C(R wherein R (i) a hydrogen atom; (ii) CH (e) a haloalkyl of 1 to 8 carbon atoms, inclusive, and 1 to 6 halogen atoms, inclusive, straight chain or branched; and wherein R (a) a hydrogen atom; (b) an alkyl from 1 to 4 carbon atoms, inclusive, straight chain or branched; (c) a halogen; wherein R (a) a hydrogen atom; (b) an alkyl of 1 to 8 carbon atoms, inclusive, which can be straight chain or branched; (c) a cycloalkyl of 3 to 6 carbon atoms, inclusive; (d) an alkenyl of 2 to 8 carbon atoms, inclusive, which can be straight chain or branched; or (e) R wherein Q wherein R wherein Y wherein the other is (a) a hydrogen atom; (b) CH wherein a+b=3, a=0 to 3, b=0 to 3, and wherein each Z, independently, is a cyano, a nitro, or a halogen atom; (c) an alkyl of 2 to 4 carbon atoms, inclusive, straight chain or branched; (d) an alkoxy of 1 to 4 carbon atoms, inclusive, straight chain or branched; or Y (a) ═NH; or (b) ═O; wherein Y wherein the other is (a) a hydrogen atom; (b) CH where a+b=3, a=0 to 3, b=0 to 3 wherein each Z, independently, is a cyano, a nitro, or a halogen atom; (c) an alkyl of 2 to 4 carbon atoms, inclusive, straight chain or branched; (d) an alkoxy of 1 to 4 carbon atoms, inclusive, straight chain or branched; or Y (a) ═NH; or (b) ═O; wherein R a is (a) a hydrogen atom; or (b) alkyl of 1 to 8 carbon atoms; wherein R (a) substituted phenyl wherein Z (b) a substituted phenoxy wherein Z wherein Z wherein R b and R c are each independently: (a) a hydrogen atom; (b) a hydroxyl, or a thiol; (c) a methyl or a halomethyl; (d) a halogen; (e) an alkoxy of 1 to 3 carbon atoms; wherein R (a) a hydrogen atom; (b) a hydroxyl, or thiol; (c) a methyl or halomethyl; (d) a halogen; (e) an alkoxy of 1 to 3 carbon atoms; or (f) an alkyl or haloalkyl of 2 to 4 carbon atoms, inclusive, which can be straight chain or branched; and wherein formula II is: wherein X is R wherein R wherein Z wherein Q wherein Q wherein one of R wherein R wherein R wherein Z wherein Y wherein R wherein T is O or S, and pharmaceutically acceptable salts thereof, such that the subject with sepsis is treated.