Patent ID: 6090805
Filing Date: 2000-07-18
Classification: C07D

Abstract:
A compound of the formula ##STR60## wherein Z is selected from: CH.sub.2 O, where O is attached directly to the carbonyl of the ring; CH.dbd.CH; or CH.sub.2 CH.sub.2 ;X is selected from O, CH.sub.2, CF.sub.2, ##STR61## R.sup.1 is selected from hydrogen, halogen or C.sub.1-5 alkyl; R.sup.2 is selected from hydrogen, C.sub.1-5 alkyl, hydroxymethyl or CONH.sub.2 ;R.sup.3 is trifluoromethoxy or trifluoroethoxy;R.sup.4 is selected from hydrogen; halogen; C.sub.1-5 alkyl; mono- or polyhalogenated C.sub.1-5 alkyl; C.sub.1-5 alkoxy; mono- or polyhalogenated C.sub.1-5 alkoxy; substituted C.sub.1-5 alkoxy wherein the substituent on alkoxy is selected from carboxy, CO.sub.2 --C.sub.1-5 alkyl, CON(R.sup.8).sub.2, N(R.sup.8).sub.2 or morpolinyl; S--C.sub.1-5 alkyl; SO--C.sub.1-5 alkyl; SO.sub.2 --C.sub.1-5 alkyl; NHR.sup.5 ; CN; carboxy; CO--C.sub.1-5 alkyl; CON(R.sup.8).sub.2 ; pyridinyloxy; pyridinyloxy-N-oxide; triazolyl; tetrazolyl; morpholinyl; unsubstituted or substituted phenoxy wherein the phenoxy is substituted with one to three sub-stituents independently selected from C.sub.1-5 alkyl, halogen, CF.sub.3 or CN; ##STR62## R.sup.5 is selected from hydrogen, CO.sub.2 --C.sub.1-5 alkyl or COCH.sub.2 -Het;each R.sup.8 is independently selected from hydrogen or C.sub.1-5 alkyl;R.sup.9 is selected from hydrogen, C.sub.1-5 alkyl, C.sub.3-6 cycloalkyl substituted C.sub.1-5 alkyl, CO.sub.2 --C.sub.1-5 alkyl or COCH.sub.2 -Het;R.sup.10 is selected from hydrogen, C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl substituted C.sub.1-5 alkyl, mono or polyhalogenated C.sub.1-5 alkyl, mono or polyhalogenated C.sub.1-5 alkyloxycarbonyl, hydroxy C.sub.1-5 alkyl, CO.sub.2 --C.sub.1-5 alkyl, CON(R.sup.8).sub.2, CO--C.sub.1-5 alkyl, SO.sub.2 --C.sub.1-5 alkyl or ##STR63## Het is selected from pyridinyl, imidazolyl and morpholinyl; m is an integer from 1 to 5; andn is an integer from 1 to 2;and the pharmaceutically acceptable salts thereof.