Patent ID: 9072729
Filing Date: 2015-07-07
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating cancer selected from the group consisting of brain cancer, bone cancer, skin cancer, gallbladder cancer, laryngeal cancer, oral cancer, pleural mesothelioma, testicular cancer, uterine cancer, thyroid cancer, hepatocellular carcinoma and glioma in a subject in need of such cancer treatment, the method comprising administering an effective amount of an anti-cancer agent to the subject, the anti-cancer agent being: (a) an oligomer or polymer comprising three or more compounds of general formula I connected together, general formula I being defined as: wherein: the dashed line is absent or is present as a bond to form a second bond between the carbon to which R R R R R R R R in which any of R in which one of the ring carbon atom to which R or any pharmaceutically acceptable salt of the oligomer or polymer of the compound; or b) 1,3-di-tert-butylimidazolinium, 1,3-bis(1-adamantyl)imidazolium, 1,3-bis(2,4,6-trimethylphenyl)-imidazolinium, 1,3-bis(2,6-diisopropyl-phenyl)-imidazolinium, 1-(1-adamantyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium, 2-benzylimidazo[1,5-a]quinolinium, 1,3-bis(1-adamantyl)-benzimidazolium, 1,3-diisopropylimidazolinium, diisopropylphenyl)-5-methylimidazo[1,5-a]pyridinium, 1-(2,6-diisopropylphenyl)-3-(2,4,6-trimethylphenyl)-imidazolinium, 2-mesityl-5-methylimidazo[1,5-a]pyridinium, 2-mesityl-2,5,6,7-tetrahydropyrrolo[2,1-c][1,2,4]triazol-4-ium, 1,3-bis(1-adamantyl)imidazolinium, 6,7-dihydro-2-pentafluorophenyl-5H-pyrrolo[2,1-c]-1,2,4-trizolium, 1-methyl-3-(2-hydroxylethyl)-imidazolium, 1-methyl-3-(4-isocynatobenzyl)-imidazolium, 1-methyl-3-(4-acetate-benzyl)-imidazolium, 1-methyl-3-(2,2-dimethoxylethyl)-imidazolium, 1-(2,4,6-trimethylphenyl)-3-(4-acetate-benzyl)-imidazolium, 1-benzyl-3-(4-acetate-benzyl)-2-methyl-imidazolium, 1-benzyl-3-(2,2-dimethoxylethyl)-2-methyl-imidazolium, 1-benzyl-3-(4-acetatebenzyl)-5-phenyl-imidazolium, 1-benzyl-3-(4-methylbenzyl)-5-phenylimidazolium, 1-benzyl-3-(3-hydroxyl-propyl)-imidazolium, 1-benzyl-3-(4-acetatebenzyl)-imidazolium, 1-(4-cyanatobenzyl)-3-methyl-imidazolium, 1-(4-carboxybenzyl)-3-methyl-imidazolium, 1,3-Bis(2,6-diisopropylphenyl)imidazolium or 1,3-Di-tert-butylimidazolium, or any dimer thereof; or any pharmaceutically acceptable salt thereof; or c) 2,6-di-(3-benzyl-imidazolium)-pyridine, 2,2′-di-(3-benzyl-imidazolium)-1,1′-binaphthalene, (1,2-4,5-diimidazolium)-N,N′,N″,N′″-tetrabenzyl-benzene, 1,3,5-tris-(4-methyl-imiazolium)-linked cyclophane or 1,3-dibenzyl-2-(1,3-dibenzyl-1H-imidazol-2(3H)-ylidene)-2,3-dihydro-1H-imidazole; or any pharmaceutically acceptable salt thereof.