Patent ID: 6287285
Filing Date: 2001-09-11
Classification: A61L,A61M

Abstract:
An intracorporeal medical device having a therapeutic, diagnostic, or hydrophilic coating, the coating comprising:a) a polymerized base coat on the device formed from a solution of a binding component and a grafting component polymerized and crosslinked to the binding component on the device so that the grafting component bonds to the device,the binding component having at least a first functional group selected from the group consisting of polyaziridine, polycarbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with carbodiimide or tresyl or succinimide; andthe grafting component being selected from the group consisting of vinyl, acrylate and allyl compounds; andb) a top coat on the base coat, comprising a therapeutic, diagnostic or hydrophilic agent, or a complex of a therapeutic, diagnostic or hydrophilic agent and a linking agent, the therapeutic, diagnostic or hydrophilic agent or the linking agent having a functional group which bonds with the binding component, said functional group selected from the group consisting of carboxyl, hydroxy, amine, and thiol, covalently bonded to the binding component.