Patent ID: 8920490
Filing Date: 2014-12-30
Classification: A61F

Abstract:
1. A stent comprising: a porous region having a surface and a thickness, the porous region including pores having pore openings at the surface, the pores and the pore openings being formed among a series of posts or pillars and having a width of about 300 nm or less, a reservoir zone in the porous region, a portion of each of at least some pores forming a reservoir of the reservoir zone, each reservoir including a first therapeutic agent and a polymer, the portion being less than the entire pore, and a protective zone in the porous region that is substantially free of polymer, the protective zone comprising a porous channel having a pore surface defining an open protective volume over each reservoir, each open protective volume being another portion of the each of the at least some pores, and extending from the surface to a depth about 50 nm or more into the pores, wherein the porous region is configured such that the reservoir zone receives the first therapeutic agent and the polymer without the protective zone, including the pore surface in the protective zone, retaining a substantial amount of first therapeutic agent and the polymer, and wherein the porous region includes a loading port communicating with the reservoir zone such that drug and polymer is loaded directly into the reservoir zone without passing through the protective zone.