Patent ID: 6610292
Filing Date: 2003-08-26
Classification: A61K,Y10S

Abstract:
A method for inducing liquefaction of a vitreous humor to treat a disorder of a mammalian eye, said method comprising contacting with said vitreous humor of said mammalian eye an amount of hyaluronidase effective to liquefy said vitreous humor whereby said disorder is treated, wherein said hyaluronidase is defined as being free of thimerosal, essentially devoid of hyaluronic acid-lysing material having a molecular weight greater than approximately 100,000 as determined by 10% SDS PAGE electrophoresis, essentially devoid of caseinolytic material having a molecular weight greater than approximately 45,000 as determined by 15% SDS PAGE electrophoresis, and essentially devoid of gelatinolytic material having a molecular weight between approximately 60,000 and 100,000 as determined by 10% SDS PAGE electrophoresis, and wherein said hyaluronidase is defined as causing hydrolysis of the endo-N-acetyl hexosaminic bonds of hyaluronic acid.