Patent ID: 8171652
Filing Date: 2012-05-08
Classification: F26B

Abstract:
1. A method of filling a device with a substance to be lyophilized, lyophilizing the substance within the device, and storing the lyophilized substance within the device, the method comprising the following steps: filling a device including a body defining a chamber enclosed by a liquid-impermeable closure in sealing engagement therewith and a penetrable and resealable portion in fluid communication with the chamber, the filling step comprising: lyophilizing the substance within the chamber with the closure in engagement with the body, causing fluid to flow out of the chamber during lyophilization, and preventing at least one of contaminants and moisture from flowing into the chamber during lyophilization; and hermetically sealing an aperture formed by the injection or filling member in the penetrated region of the penetrable and resealable portion.