Patent ID: 6277847
Filing Date: 2001-08-21
Classification: C07D

Abstract:
A compound represented by formula (I): ##STR11##X, Y, and Z are as follows: (i) X is hydrogen, halogen, (C.sub.1 -C.sub.10)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxyl, halo(C.sub.1 -C.sub.6)alkoxyl, cyano, amido, or nitro; Y is hydrogen, halogen, (C.sub.1 -C.sub.6)alkyl, or halo(C.sub.1 -C.sub.6)alkyl; and Z is hydrogen, (C.sub.1 -C.sub.3)alkyl, halogen, amino, nitro, (C.sub.1 -C.sub.3)alkoxyl, or hydroxyl with the proviso that when Z is (C.sub.1 -C.sub.3)alkyl, halogen, amino, nitro, (C.sub.1 -C.sub.3)alkoxyl, or hydroxyl, X is not a hydrogen and Y is not a hydrogen; or (ii) X and Z are connected to each other to form part of a 4, 5, or 6 membered ring, and Y is as defined above, or Y and Z are connected to each other to form part of a 4, 5, or 6 membered ring and X is defined above;n is 1 or 2;R is hydrogen, amino, (C.sub.1 -C.sub.10)alkyl, halo(C.sub.1 -C.sub.10)alkyl, cyanomethyl, hydroxyl, (C.sub.1 -C.sub.6)alkoxyl, 2-methoxyethyl, methoxymethyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, prop-2-enyl, prop-2-enyloxy, prop-2-ynyl, ethoxycarbonylmethyl, 2-(methoxycarbonyl)ethyl, phenylmethyl, 4-chlorophenylmethyl, or 4-methoxyphenylmethyl; andR.sub.1 is hydrogen, amino, (C.sub.1 -C.sub.6)alkyl, difluoromethyl, 3-fluoropropyl, methoxymethyl, cyanomethyl, phenylmethyl, prop-2-enyl, prop-2-ynyl, ethoxycarbonylmethyl, or salts thereof.