Patent ID: 7910612
Filing Date: 2011-03-22
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein R1 is selected from the group consisting of (C1-C6) alkyl, (C0-C6) alkylene-(C3-C6) cycloalkyl, (C0-C6) alkylene-O-(C1-C6) alkyl, (C0-C6) alkylene-O-(C3-C6) cycloalkyl, (C0-C6) alkylene-(C6-C14) aryl, and (C0-C6) alkylene-(C5-C15) heteroaryl, wherein alkyl, alkylene, aryl and cycloalkyl are unsubstituted or mono-, di- or tri-substituted by F, Cl, Br, (C1-C6) alkyl, O-(C1-C6) alkyl, CF R2 and R3 are independently selected from the group consisting of H, halogen, (C1-C6) alkyl, (C0-C4) alkylene-O-(C0-C4) alkylene-H, SCH3 and CN, wherein alkyl and alkylene is unsubstituted or mono-, di- or trisubstituted by F; R4, R5, R6 and R7 are independently selected from the group consisting of H, (C1-C6) alkyl, (C0-C4) alkylene-(C3-C6) cycloalkyl, (C0-C6) alkylene-(C6-C14) aryl, (C0-C6) alkylene-(C5-C15) heteroaryl, (C0-C6) alkylene-(C3-C15) heterocycloalkyl and (C0-C6) alkylene-(C3-C15) heterocycloalkenyl, wherein alkyl, cycloalkyl, aryl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are unsubstituted or mono-, di- or trisubstituted by F, Cl, Br, CF3, (C1-C4) alkyl and (C0-C4)-alkylene-O-(C0-C4) alkylene-H; m is 0 or 1; A is (C6-C14) aryl or (C5-C15) heteroaryl; B is selected from the group consisting of (C6-C14) aryl, (C3-C12) cycloalkyl, and (C5-C15) heteroaryl; Z is a bond, O or Ring A and Ring B together form an annealed (C5-C15) heterocyclic or (C8-C14) aromatic ring system; and Z is absent; R8 and R9 are independently selected from the group consisting of H, halogen, (C1-C6) alkyl, (C0-C4) alkylene-O-(C0-C4) alkylene-H, SCF3, SF5, S(O)2CF3, O—(C6-C14) aryl, (C6-C14) aryl, and NO2, wherein alkyl and alkylene is unsubstituted or mono, bi- or tri-substituted by F and wherein aryl is unsubstituted or mono-, di- or tri-substituted by F, Cl, Br, CF3, (C1-C4) alkyl and (C0-C4)-alkylene-O-(C0-C4) alkylene-H; p is 0, 1, 2 or 3; q is 0, 1 or 2; its' stereoisomers, enantiomers, tautomers their salts and mixtures thereof.