Patent ID: 6903075
Filing Date: 2005-06-07
Classification: A61K,C07K

Abstract:
1. A compound having the formula Ia: or a pharmaceutically acceptable salt thereof, wherein R R wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R a ; and aryl and heteroaryl optionally substituted with one to four substituents independently selected from R b ; R wherein alkyl is optionally substituted with one to four substituents independently selected from R a ; and Cy is optionally substituted with one to four substituents independently selected from R b ; R wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from phenyl and R x , and Cy is optionally substituted with one to four substituents independently selected from R y ; or R R wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from R x , and aryl and heteroaryl are optionally substituted with one to four substituents independently selected from R y ; or R R 1) a group selected from R 2) a group selected from R R R wherein Cy is optionally subsituted with one to four substituents independently selected from R c ; R wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl are optionally substituted with a group independently selected from R c ; R R d and R e are independently selected from hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, Cy and Cy C 1-10 alkyl, wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R c ; or R R R R wherein alkyl, alkenyl, alkynyl and aryl are each optionally substituted with one to four substituents independently selected from R c ; R R wherein alkyl, alkenyl, alkynyl and aryl are each optionally substituted with one to four substituents independently selected from R x ; Cy is cycloalkyl, heterocyclyl, aryl, or heteroaryl; m is an integer from 1 to 2; n is an integer from 1 to 10; X is —C(O)OR Z is selected from —C— and —C—C—; B is selected from the group consisting of with the proviso that R 6 /R 7 is not oxo when attached to the carbon between N and B.