Patent ID: 6545016
Filing Date: 2003-04-08
Classification: C07D

Abstract:
A compound of the formula (I): whereinX is alkylene or alkenylene; Y is â€”COâ€” or â€”CSâ€”; Z is a bond, â€”Oâ€”, or â€”Sâ€”; R1 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, each of which may be unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -substituted cycloalkyl; -substituted aryl; -substituted heteroaryl; substituted heterocyclyl; â€”O-alkyl; â€”O-(alkyl)0-1-aryl; â€”O-(alkyl)0-1-substituted aryl; â€”O-(alkyl)0-1-heteroaryl; â€”O-(alkyl)0-1-substituted heteroaryl; â€”O-(alkyl)()0-1-heterocyclyl; â€”O-(alkyl)0-1-substituted heterocyclyl; â€”COOH; â€”COâ€”O-alkyl; â€”CO-alkyl; â€”S(O)0-2-alkyl; â€”S(O)0-2-(alkyl)0-1-aryl; â€”S(O)0-2-(alkyl)0-1-substituted aryl; â€”S(O)0-2-(alkyl)0-1-heteroaryl; â€”S (O)0-2-(alkyl)0-1-substituted heteroaryl; â€”S(O)0-2-(alkyl)0-1-heterocyclyl; â€”S(O)0-2-(alkyl)0-1-substituted heterocyclyl; -(alkyl)0-1-N(R6)2; -(alkyl)0-1-NR6â€”COâ€”O-alkyl; -(alkyl)0-1-NR6â€”CO-alkyl; -(alkyl)0-1-NR6â€”CO-aryl; -(alkyl)0-1-NR6â€”CO-substituted aryl; -(alkyl)0-1-NR6â€”CO-heteroaryl; -(alkyl)0-1-NR6â€”CO-substituted heteroaryl; â€”N3; -halogen; -haloalkyl; -haloalkoxy; â€”CO-haloalkyl; â€”CO-haloalkoxy; â€”NO2; â€”CN; â€”OH; â€”SH; and in the case of alkyl, alkenyl, and heterocyclyl, oxo; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -alkyl-O-alkyl; -alkyl-S-alkyl; -alkyl-O-aryl; -alkyl-S-aryl: -alkyl-O-alkenyl; -alkyl-S-alkenyl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R6)2; â€”COâ€”N(R6)2; â€”CSâ€”N(R6)2; â€”SO2â€”N(R6)2; â€”NR6â€”COâ€”C1-10 alkyl; â€”NR6â€”CSâ€”C1-10 alkyl; â€”NR6â€”SO2â€”C1-10 alkyl; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -heterocyclyl; -substituted heterocyclyl; â€”CO-aryl; â€”CO-(substituted aryl); â€”CO-heteroaryl; and â€”CO-(substituted heteroaryl); R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialkylamino and alkylthio; R5 is H or C1-10 alkyl, or R5 can join with X to form a ring that contains one or two hetero atoms; or when R1 is alkyl, R5 and R1 can join to form a ring; each R6 is independently H or C1-10 alkyl; or a pharmaceutically acceptable salt thereof.