Patent ID: 6114360
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR11## in which: R represents:hydrogen,a linear or branched (C.sub.1 -C.sub.6)-alkyl optionally substituted by one or more identical or different groups selected from hydroxy, linear or branched (C.sub.1 -C.sub.6)-alkoxy, carboxy, and linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl,an amino optionally substituted by one or two identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl, linear or branched aryl-(C.sub.1 -C.sub.6)-alkoxycarbonyl, linear or branched (C.sub.1 -C.sub.6)-alkylsulphonyl, and arylsulphonyl,or a linear or branched (C.sub.1 -C.sub.6)-acyl,R.sub.1 and R.sub.2, which may be identical or different, each represents aryl, pyridyl, or (C.sub.3 -C.sub.7)-cycloalkyl, at least one of R.sub.1 and R.sub.2 being a pyridyl group, or one of those R.sub.1 or R.sub.2 groups which is substituted by one or more identical or different groups selected from:halogen,linear or branched (C.sub.1 -C.sub.6)-alkyl optionally substituted by one or more identical or different substituents selected from halogen, hydroxy, linear or branched (C.sub.1 -C.sub.6)-alkoxy, amino, and linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl,linear or branched (C.sub.1 -C.sub.6)-alkoxy optionally substituted by amino which is itself optionally substituted by one or two identical or different linear or branched (C.sub.1 -C.sub.6)-alkyl,linear or branched (C.sub.1 -C.sub.6)-trihaloalkoxy,linear or branched (C.sub.1 -C.sub.6)-acyl,hydroxy, nitro, cyano, mercapto, or carboxy,amino optionally substituted by one or two identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.6)-alkylcarbonyl, and linear or branched (C.sub.1 -C.sub.6)-alkylsulphonyl,linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl,linear or branched (C.sub.1 -C.sub.6)-alkylthio,sulphonyl substituted by linear or branched (C.sub.1 -C.sub.6)-alkyl or by amino which is optionally substituted by one or two identical or different linear or branched (C.sub.1 -C.sub.6)-alkyl, andpyridyl optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, and linear or branched (C.sub.1 -C.sub.6)-alkoxy,A represents, together with the atoms in common with the pyrrole:a saturated or mono-unsaturated monocyclic or bicyclic (C.sub.3 -C.sub.12)-cycloalkyl,a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen,or 7-oxabicyclo[2.2.1]heptane,or one of the said A groups which is substituted by one or more identical or different groups selected from:halogen,trihalomethyl,linear or branched (C.sub.1 -C.sub.6)-alkyl optionally substituted by one or more halogen or hydroxy groups,linear or branched (C.sub.1 -C.sub.6)-alkoxy,linear or branched (C.sub.1 -C.sub.6)-aminoalkyl,cyano,aryl or linear or branched aryl-(C.sub.1 -C.sub.6)-alkyl, the aryl of the said groups being optionally substituted by one or more identical or different groups selected from halogen, hydroxy, linear or branched (C.sub.1 -C.sub.6)-alkyl, and linear or branched (C.sub.1 -C.sub.6)-alkoxy,and sulphonyl substituted by linear or branched (C.sub.1 -C.sub.6)-alkyl or by amino which is itself optionally substituted by one or two identical or different linear or branched (C.sub.1 -C.sub.6)-alkyl,their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base,provided that:if R.sub.2 represents 4-pyridyl optionally substituted by one or more groups selected from halogen, linear or branched (C.sub.1 -C.sub.6)-alkyl (itself optionally substituted by hydroxy or linear or branched (C.sub.1 -C.sub.6)-alkoxy), hydroxy, nitro, amino, linear or branched (C.sub.1 -C.sub.6)-acyl, and linear or branched (C.sub.1 -C.sub.6) -alkoxycarbonyl,and R.sub.1 represents phenyl, naphthyl, or pyridyl, each of those groups being optionally substituted by one or two groups selected from halogen, linear or branched (C.sub.1 -C.sub.4)-alkyl optionally substituted by halogen, linear or branched (C.sub.1 -C.sub.4)-alkoxy, nitro, hydroxy, amino optionally substituted by one or two linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.4)-alkoxycarbonyl, and linear or branched (C.sub.1 -C.sub.4)-alkylthio,then A, together with the atoms in common with the pyrrole ring, cannot represent a saturated monocyclic (C.sub.5 -C.sub.8)-cycloalkyl, each of such groups optionally being substituted by one or two groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.4)-alkoxy, and aryl.