Patent ID: 8129395
Filing Date: 2012-03-06
Classification: A61K,A61P,C07D

Abstract:
1. A compound according to Formula II: or a pharmaceutically acceptable salt thereof, wherein: Ar is mono-, di-, or tri-substituted phenyl, optionally substituted naphthyl, or optionally substituted heteroaryl having from 1 to 3 rings and 5 to 7 ring members in each ring; A is OR R R R R R E is a single covalent bond, oxygen, or NR X is a single covalent bond, —CR R W is a single covalent bond, —CR Z is independently selected at each occurrence from 3- to 7-membered carbocycles and heterocycles, each of which is substituted with from 0 to 4 substituents independently selected from halogen, oxo, —COOH, C(O)NH R R R m is independently selected at each occurrence from integers ranging from 0 to 8; and n is an integer independently selected at each occurrence from 0, 1 and 2.