Patent ID: 6191130
Filing Date: 2001-02-20
Classification: A61P,C07D

Abstract:
Difunctionalized cyclohexane derivatives selected from those of formula I ##STR47##in whichA represents a group of formula ##STR48##in which Ar represents a structure chosen from phenyl and pyrimidinyl, optionally substituted by one or more C.sub.1-3 alkyl, C.sub.1 -C.sub.3 alkoxy, trifluoromethyl, and halogen, ##STR49##B represents a heterocyclic group selected from3,5-dioxo-(2H,4H)-1,2,4-triazine substituted at the 2 position, (IIIa) ##STR50##3-oxo-(2H)-1,2,4-triazine substituted at the 5 position, (IIIb) ##STR51##and:3,5-dioxo-6-amino-(2H,4H)-1,2,4-triazine, (IIIc) ##STR52##in which R represents a C.sub.1 -C.sub.3 alkyl group, and salts thereof with pharmaceutically-acceptable acids, ""cis"" and ""trans"" isomers thereof, and enantiomers of the compounds possessing asymmetric carbons.