Patent ID: 9155787
Filing Date: 2015-10-13
Classification: A61K,A61P,C07K

Abstract:
1. A method for preventing rejection of a tissue transplanted from a donor subject into a recipient subject comprising: a) administering to the recipient subject, prior to transplantation of the tissue, (i) a plurality of peripheral blood mononuclear cells (PBMCs) from the donor subject, wherein the PBMCs have been irradiated and do not proliferate in vivo, and (ii) an anti-CD40 ligand (anti-CD40L) antibody; and b) administering to the recipient subject, subsequent to transplantation of the tissue, (i) dendritic cells loaded with a type B self peptide, or (ii) a membrane-bound, HLA-E-bearing composition loaded with a type B peptide,