Patent ID: 7695903
Filing Date: 2010-04-13
Classification: A61P,C12Q,G01N

Abstract:
1. A method of at least diagnosing a human patient with Alzheimer's disease, said method comprising: (a) measuring at least abundance of low-density lipoprotein receptor related protein-1 (LRP-1), abundance of transcripts thereof, or LRP-1 receptor activity in a human patient, (b) comparing the abundance of LRP-1 protein, abundance of transcripts thereof, or activity of LRP-1 receptor in said human patient to at least an age-matched control not affected by Alzheimer's disease, and (c) at least diagnosing said human patient with Alzheimer's disease when the abundance of LRP-1 protein, abundance of transcripts thereof, or activity of LRP-1 receptor in said human patient is decreased relative to said age-matched control not affected by Alzheimer's disease; wherein LRP-1 mediated removal of amyloid-β peptide (Aβ) at the blood-brain barrier in the direction from brain to blood in said human patient is decreased as compared to an age-matched control not affected by Alzheimer's disease.