Patent ID: 6372736
Filing Date: 2002-04-16
Classification: A61P,C07D

Abstract:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof, whereinA is unbranched C3-C5 alkylene optionally substituted by C1-C6 alkyl; X is O, S, NH or N(C1-C6 alkyl); Y is O, S, NH or N(C1-C6 alkyl); R is a C-linked, 4- to 6-membered ring, non-aromatic, heterocyclic group containing one nitrogen heteroatom, said group being optionally substituted by 1, 2 or 3 substituent(s) each independently selected from C1-C6 alkyl, C2-C6 alkenyl, C3-C7 cycloalkyl, aryl, het, â€”CO2(C1-C6 alkyl), â€”CO(het), â€”CONR5R6 and â€”CO(aryl), said alkyl and alkenyl being optionally substituted by 1 or 2 substituent(s) each independently selected from C3-C7 cycloalkyl, aryl, het, â€”O(aryl), â€”O(C1-C2 alkylene)aryl, â€”CO(het), â€”CONR5R6 and â€”CO(aryl); R1, R2, R3 and R4 are each independently selected from H, halo, C1-C6 alkyl, C3-C7 cycloalkyl, halo(C1-C6) alkyl, C1-C1 alkoxy, â€”CONR5R6, C3-C7 cycloalkoxy, C3-C7 cycloalkyl-(C2-C4) alkylene, C3-C7 cycloalkyl(C2-C4) alkoxy and â€”CO2(C1-C6 alkyl); R5 and R6 are either each independently selected from H and C1-C6 alkyl or, when taken together, represent unbranched C3-C5 alkylene; ary is phenyl, optionally substituted by 1, 2 or 3 substituent(s) each independently selected from C1-C6 alkyl, C1-C6 alkoxy, halo, â€”CONR5R6, halo(C1-C6 alkyl) and â€”NR5R6; and het is a heterocyclic group selected from the group consisting of a 5- or 6-membered monocyclic ring and an 8-, 9- or 10-membered bicyclic ring, wherein said heterocyclic group contains from 1 to 3 heteroatoms each independently selected from N, O and S, and said heterocyclic group is optionally substituted by 1, 2 or 3 substituent(s) each independently selected from C1-C6 alkyl, C1-C6 alkoxy, halo, halo(C1-C6 alkyl), phenyl and â€”NR5R6.