Patent ID: 6949506
Filing Date: 2005-09-27
Classification: A61K,A61P,C07K

Abstract:
1. A method of decreasing collagen synthesis, comprising: administering a synthetic relaxin-like factor to cells of a human, wherein said cells express relaxin receptors; and allowing the synthetic relaxin-like factor to contact the receptors for a period of time and under conditions such that the receptors are activated, and collagen synthesis is decreased; the synthetic relaxin-like factor comprising an A chain and a B chain, said A chain having the amino acid sequence: or said amino acid sequence (SEQ ID NO:3) truncated by up to about 6 amino acids from the N terminus and/or by up to 6 amino acids from the C-terminus; said B chain having the amino acid sequence: or said amino acid sequence (SEQ ID NO:4) truncated by up to 5 amino acids from the N-terminus and/or by up to 5 amino acids from the C-terminus; said A and B chains linked by disulfide bonds between amino acid residue number 11 of SEQ ID NO:3 and amino acid number 10 of SEQ ID NO:4.