Patent ID: 6140113
Filing Date: 2000-10-31
Classification: A61K,C07K,C12N

Abstract:
A polynucleotide which encodes:a first fusion protein comprising (i) an immunoglobulin heavy chain, wherein the immunoglobulin heavy chain comprises a variable region, and (ii) an extracellular domain of a first transmembrane polypeptide of a heterodimeric protein, wherein the immunoglobulin heavy chain is C-terminal to the extracellular domain of the first transmembrane polypeptide; anda second fusion protein comprising (i) an immunoglobulin light chain and (ii) an extracellular domain of a second transmembrane polypeptide of the heterodimeric protein, wherein the immunoglobulin light chain is C-terminal to the extracellular portion of the second transmembrane polypeptide,wherein the extracellular domain of the first transmembrane polypeptide and the extracellular domain of the second transmembrane polypeptide form a ligand binding site for a cognate ligand.