Patent ID: 6017939
Filing Date: 2000-01-25
Classification: C07D

Abstract:
A compound of formula I ##STR25## in which R is ##STR26## X is O or S, R.sup.1 is H, Hal, OH, OA, A, alkylene-O-A, NO.sub.2, NH.sub.2, NHacyl, SO.sub.2 NH.sub.2, SO.sub.3 -A, SO.sub.2 NHA, CN or formyl,R.sup.2,R.sup.3,R.sup.4 in each case independently of one another are a phenyl group which is unsubstituted or mono- or polysubstituted by Hal, OH, OA, O-alkylene-R.sup.5, A, S-A, S-OA, SO.sub.2 A, S-OR.sup.5, SO.sub.2 R.sup.5, NO.sub.2, NH.sub.2, NHA, NA.sub.2, NHacyl, NHSO.sub.2 A, NHSO.sub.Z R.sup.5, NASO.sub.2 A, NASO.sub.2 -R.sup.5, NH(CO)NH.sub.2, NH(CO)NHA, formyl, NH(CO)NHR.sup.5, NHCOOA, NAacyl, NHCOOCH.sub.2 R.sup.5, NHSO.sub.2 CH.sub.2 R.sup.5, NHCOO-alkylene-OA, NH(CO)NA.sub.2, 1-piperidinyl-CO--NH, 1-pyrrolidinyl-CONH, O (CH.sub.2).sub.n COOA, O(CH.sub.2).sub.n COOH, O(CH.sub.2).sub.n OH, O(CH.sub.2).sub.n OA , CH.sub.2 OH, CH.sub.2 OA, COOH, COOA, CH.sub.2 COOH or CH.sub.2 COOA, ##STR27## whereR.sup.2 is additionally A or cycloalkyl,R.sup.5 is a phenyl group which is unsubstituted or mono- or polysubstituted by Hal, OH, OA, A, S-A, NO.sub.2, NH.sub.2, NHA, NA.sub.2, NHacyl, NHSO.sub.2 A, NASO.sub.2 A, NH(CO)NH.sub.2, NH(CO)NHA, formyl, NHCOOA, NAacyl, NHCOO-alkylene-OA, NH(CO)NA.sub.2, N-piperidinyl-CO-NH , N-pyrrolidinyl-CONH, O(CH.sub.2).sub.n COOA, O(CH.sub.2).sub.n COOH, O(CH.sub.2).sub.n OH, O(CH.sub.2).sub.n OA , CH.sub.2 OH CH.sub.2 OA, COOH, COOA, CH.sub.2 COOH or CH.sub.2 COOA,A is alkyl having 1-6 C atoms, in which one or two CH.sub.2 groups can be replaced by O or S atoms or by --CR.sup.6 .dbd.CR.sup.6 ' groups and/or 1-7 H atoms can be replaced by F,D is carbonyl or [C(R.sup.6 R.sup.6 ')].sub.m,E is CH.sub.2, S or O,Y is O or S,R.sup.6 and R.sup.6 in each case independently of one another are H, F or A,Hal is fluorine, chlorine, bromine or iodine,n is 0, 1 or 2 andm is 1 or 2,or a tautomeric ring-closed form,or a pharmaceutically acceptable salt thereof.