Patent ID: 6077523
Filing Date: 2000-06-20
Classification: A61K

Abstract:
A pharmaceutical implant for the delivery of an effective amount of a bioactive and water-soluble peptide or peptide analog over a period of 1 to 12 months, said implant having a diameter of about 1 to 2 mm and a length of between about 10 and 25 mm and being obtainable from a process which comprises:grinding a copolymer of lactic acid and glycolic acid having a ratio of glycolide to lactide units of from about 0 to 5:1 to a particle size of between about 50 and 150 .mu.m;wetting said ground and sterilized copolymer with a sterile aqueous slurry of a bioactive peptide or peptide analog;blending the copolymer and the slurry to obtain a homogeneous mixture of said copolymer and between about 10 and 50% of the bioactive peptide or peptide analog;drying said mixture at reduced pressure and at temperature not exceeding 25.degree. C.;extruding said dried mixture at a temperature between about 70 and 110.degree. C.; andcutting a cylindrical rod from the extruded mixture to form the pharmaceutical implant.