Patent ID: 7432389
Filing Date: 2008-10-07
Classification: A61P,C07C,C07D

Abstract:
1. A protected compound of the formula (II) where R 1 is: (I) C (II) —CH (III) —CH (IV) C (V) C where R 2 is: (I) —H, (II) C (III) —(CH (IV) C (V) C (VI) —(CH where R 3 is: (I) —H, (II) C (III) —(CH (IV) C (V) C (VI) —(CH and where R where R A is: (I) —C (II) —(CH (III) —(CR or where R R (V) —(CR and where R (XIX)-cyclopentyl, -cyclohexyl, or cycloheptyl ring fused to R (XX) C (XXI) C (XXI) —(CH (XXV) (C (XXVII) —CH (XXVIII) —H, (XXIX) —(CH (XXX) —C═OC(HR where R B is: (I) —C —SN, —C≡N, —CF (II) —(CH (III) —(CR (V) —(CR (XV) —[C(R and where R (XVI) —CH(R (XIX)-cyclopentyl, -cyclohexyl, or -cycloheptyl ring fused to R (XX) C (XXI) C (XXIII) —CH(—R (XXV) (C (XXVII) —CH (XXVIII) —H, or (XXIX) —(CH where PROTECTING GROUP is selected from the group consisting of t-butoxycarbonyl, benzyloxycarbonyl, formyl, trityl, acetyl, trichloroacetyl, dichloroacetyl, chloroacetyl, trifluoroacetyl, difluoroacetyl, fluoroacetyl, 4-phenylbenzyloxycarbonyl, 2-methylbenzyloxycarbonyl, 4-ethoxybenzyloxycarbonyl, 4-fluorobenzyloxycarbonyl, 4-chlorobenzyloxycarbonyl, 3-chlorobenzyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 2,4-dichlorobenzyloxycarbonyl, 4-bromobenzyloxycarbonyl, 3-bromobenzyloxycarbonyl, 4-nitrobenzyloxycarbonyl, 4-cyanobenzyloxycarbonyl, 2-(4-xenyl)isopropoxycarbonyl, 1,1-diphenyleth-1-yloxycarbonyl, 1,1-diphenylprop-1-yloxycarbonyl, 2-phenylprop-2-yloxycarbonyl, 2-(p-toluyl)prop-2-yloxycarbonyl, cyclopentanyloxycarbonyl, 1-methylcyclopentanyloxycarbonyl, cyclohexanyloxycarbonyl, 1-methylcyclohexanyloxycabonyl, 2-methylcyclohexanyloxycarbonyl,2-(4-toluylsulfonyl)ethoxycarbonyl, 2-(methylsulfonyl)ethoxycarbonyl, 2-(triphenylphosphino)ethoxycarbonyl, fluorenylmethoxycarbonyl, 2-(trimethylsilyl)ethoxycarbonyl, allyloxycarbonyl, 1-(trimethylsilylmethyl)prop-1-enyloxycarbonyl, 5-benzisoxalylmethoxycarbonyl, 4-acetoxybenzyloxycarbonyl, 2,2,2-trichloroethoxycarbonyl, 2-ethynyl-2-propoxycarbonyl, cyclopropylmethoxycarbonyl, 4-(decyloxyl)benzyloxycarbonyl, isobornyloxycarbonyl and 1-piperidyloxycarbonyl, 9-fluorenylmethyl carbonate, —CH—CH═CH