Patent ID: 6710039
Filing Date: 2004-03-23
Classification: A61P,C07J

Abstract:
Unsaturated 14,15-cyclopranoandrostanes of the formula (I): wherein R1 is a hydrogen atom, a hydroxy group, a C1-10-alkyl, a C1-10-alkyloxy, a C1-15 acyloxy, a C4-15-aryloxy, a C7-15-aralkyloxy or a C7-15-alkylaryloxy group; R2 represents a hydrogen atom, a hydroxy group, a C1-10 alkyl group, a C1-10 acyl group, a C1-10 acyloxy group, a C6-15 aryl group, a C7-15 aralkyl group, a C7-15 alkylaryl group, a â€”(CH2)nCH2Y group in which n=0, 1 or 2 and Y represents a halogen atom or a pseudohalogen; in which m=0, 1, 2 or 3 and p=0, 1 or 2 and R6 represents a hydrogen atom, a C1-10-alkyl group, a C6-15 aryl group, a C7-15 aralkyl group, a C7-15 alkylaryl group, a hydroxyl group, a C1-10 alkyloxy group or a C1-10 acyloxy group; in which o=0, 1 or 2 and R7 represents a hydrogen atom, a halogen atom, a C1-10 alkyl group, a C6-15 aryl group, a C7-15 aralkyl group, a C7-15 alkylaryl group or a C1-10 acyl group; or R1 and R2 together represent a keto group, a methylene group, a difluoromethylene group or, with inclusion of C-17, a spirooxirane or a 2,2-dimethyl-1,3-dioxolane; in which optionally a 1,2 double bond is present; R3 represents a hydrogen atom or a &agr;-C1-10 alkyl group or a &bgr;-C1-10 alkyl group; R4 represents a halogen atom, a pseudohalogen, a hydroxy group or a perfluoroalkyl group; R5 represents a C1-4 alkyl group; in which an &agr;-cyclopropane group or a &bgr;-cyclopropane group is between C-14 and C-15; with the proviso that, if said 1,2-double bond is present, then R4 can be a hydrogen atom in addition to said halogen atom, said pseudohalogen, said hydroxy group or said perfluoroalkyl group; or pharmaceutically tolerated salts thereof.