Patent ID: 6548668
Filing Date: 2003-04-15
Classification: A61K,A61P,C07F,C07K

Abstract:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein:P is R7â€”C(O)â€” or R7â€”SO2â€”, and R7 is heteroaryl or a saturated or partially unsaturated heterocycle; A is 1; B1 is CH; X1 is â€”C(O)â€”NHâ€”; X2 is â€”C(O)â€”NHâ€”; R is hydrogen or alkyl; R1 is hydrogen, C1-8alkyl, C3-10cycloalkyl, C6-10aryl, or â€”CH2â€”R5, where the ring portion of said aryl can be optionally substituted; R2 is hydrogen, C1-8alkyl, C3-10cycloalkyl, C6-10aryl, or â€”CH2â€”R5, where the ring portion of said aryl can be optionally substituted; R3 is C4alkyl; R5 is one of C6-10aryl, C6-10ar(C1-6)alkyl, C1-6alk(C6-10)aryl, C3-10 cycloalkyl, C1-8alkoxy or â€”Wâ€”R6, where W is a chalcogen and R6 is alkyl, where the ring portion of any of said aryl, aralkyl, or alkaryl can be optionally substituted; and Z1 and Z2 are independently one of hydroxy, alkoxy, or aryloxy, or together Z1 and Z2 form a moiety derived from a dihydroxy compound having at least two hydroxy groups separated by at least two connecting atoms in a chain or ring, said chain or ring comprising carbon atoms and, optionally, a heteroatom or heteroatoms which can be N, S, or O.