Patent ID: 6413512
Filing Date: 2002-07-02
Classification: A23L,A61K,C12N

Abstract:
A method of treating an alpha2 macroglobulin mediated disease in a mammal in need thereof, comprising: orally administering to the mammal a pharmaceutical composition comprising two or more proteolytic enzymes from a microbial source selected from the group consisting of Aspergillus oryzae, Aspergillus niger, Aspergillus sojae, Aspergillus flavus, Aspergillus awamori, and Bacillus subtilis, in an amount from about 20,000 HUT (or equivalent biological activity) to about 550,000 HUT (or equivalent biological activity) per day; wherein the disease is selected from the group consisting of rheumatoid disease, obesity, cachexia, hypertension, cardiovascular disease, dyslipoproteinemia, insulin resistance, non-insulin dependent diabetes, Crohn's disease, dementia, Alzheimer's disease, infection, and soft tissue injury.