Patent ID: 8354372
Filing Date: 2013-01-15
Classification: A61K,A61P

Abstract:
1. An oral pharmaceutical preparation consisting of: at least one synthetically cyclised α-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide comprising four cysteine residues bonded in pairs to form two disulfide bonds, one disulfide bond between cysteine residues I and III and one disulfide bond between cysteine residues II and IV, wherein the N-terminus of the corresponding linear/noncyclised conotoxin peptide is linked to the C-terminus by a peptide linker, and wherein the corresponding linear/noncyclised α-conotoxin peptide comprises: in which Xaa 1 is glycine or aspartate, Xaa 2 to Xaa 7 represent any naturally occurring or unnatural amino acid, Xaa 8 represents proline, hydroxyproline, serine, or glutamine, Xaa 9 represents aspartate, glutamate, γ-carboxyglutamate, glycine, or asparagine, and Xaa 10 represents any naturally occurring or unnatural amino acid or may be absent in a vehicle which is pharmaceutically suitable for oral administration.