Patent ID: 8969015
Filing Date: 2015-03-03
Classification: G01N

Abstract:
1. A method for determining the presence of, or a predisposition to develop, Sjögren's syndrome in a human comprising: a) measuring the level of an LMP-2 protein isoform in a first sample obtained from said human comprising b) measuring a change in the level of phosphorylation of one or more proteins in said first sample, or in a second sample from said human, wherein said one or more proteins comprise extracellular signal-regulated protein kinase (ERK); wherein a reduction in the level of said LMP-2 protein isoform, relative to a control, and a change in the level of phosphorylation of said one or more proteins, relative to a control, is indicative of the presence of, or a predisposition to develop, Sjögren's syndrome.