Patent ID: 8648089
Filing Date: 2014-02-11
Classification: A61P,C07D

Abstract:
1. A method of inhibiting a Raf protein kinase comprising contacting a cell with a pharmaceutical composition comprising an active ingredient that is a 1,3,6-substituted indole compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof: wherein X and Y are independently selected from N or CH; Z is selected from the group consisting of hydrogen; halogen; linear, branched or cyclic saturated or unsaturated C G is selected from the group consisting of halogen; 5- to 7-membered substituted or unsubstituted aryl; 5- to 7-membered substituted or unsubstituted heteroaryl containing 1 to 3 heteroatom(s) selected from nitrogen, oxygen and sulfur; and a 5- to 7-membered substituted or unsubstituted heterocyclic group containing 1 to 3 heteroatom(s) selected from nitrogen, oxygen and sulfur; L L E is selected from the group consisting of hydrogen; linear, branched or cyclic saturated or unsaturated C R R wherein the above aryl, heteroaryl, biaryl or heterocyclic is independently substituted or unsubstituted with 1 to 3 substituent(s) selected from the group consisting of hydrogen; halogen; linear, branched or cyclic saturated or unsaturated C R