Patent ID: 8398860
Filing Date: 2013-03-19
Classification: A61K,A61P,B01D

Abstract:
1. A method of treating a surfactant for use in a stabilized liquid pharmaceutical formulation of a lipid soluble drug for injection, the surfactant being a condensation product of castor oil and ethylene oxide and the lipid-soluble drug being susceptible to degradation in the presence of the surfactant in untreated form, which comprises: mixing the surfactant with a solvent to form a mixture; bringing said mixture into contact with a semi-permeable membrane so as to allow impurities present in the surfactant and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, wherein the mixture flows tangential to a surface of the semi-permeable membrane and purified surfactant is retained; and distilling the purified surfactant at a low pressure.