Patent ID: 7771706
Filing Date: 2010-08-10
Classification: A61B,A61K

Abstract:
1. A method for monitoring protein translation comprising: administering an amount of an angiogenesis effector molecule to an animal or animal cells; measuring, by Magnetic Resonance Spectroscopy, the amount of Choline present in an angiogenic tissue, tissues or cells before and after administering the angiogenesis effector molecule; correlating any change in the amount of Choline measured to a change in protein translation; wherein the angiogenesis effector is selected from the group consisting of VEGF receptor tyrosine kinase inhibitors, monoclonal antibodies to growth factor receptors, VEGF toxin conjugate, dominant negative VEGF-2, soluble VEGFR (VEGF-TRAP) and antisense oligonucleotides, growth factor transforming kinases, farnesyl transferase inhibitors, agents targeting tumor suppressors, agents that inhibit proliferation of endothelial cells, antibody and peptide integrin inhibitors, plasmin inhibitors, urokinase-type plasminogen activator inhibitors, matrix metalloproteinase inhibitors, cyclooxygenase inhibitors, lipoxygenase inhibitors, and inhibitors of mitogenic effects, and any combination thereof.