Patent ID: 7906515
Filing Date: 2011-03-15
Classification: A61K,A61P

Abstract:
1. A method of treatment of a tumour cell in the brain which comprises administering to a subject in need of treatment an effective amount of a topoisomerase-II poison in combination with a bis-dioxypiperazine, wherein said subject is further treated with brain radiation therapy: wherein the bis-dioxypiperazine is dexrazoxane; wherein the topoisomerase-II poison is selected from the group consisting of etoposide, etoposide phosphate, teniposide, m-amsacrine, daunorubicin and mitoxantrone; wherein the topoisomerase-II poison is administered at a dose range of from 1 to 100 mg/kg body weight and the bis-dioxypiperazine is administered at a dose range of from about 10 to about 100 mg/kg body weight; and wherein the radiation is administered at a dose of from about 1 to 100 Gy.