Patent ID: 8586615
Filing Date: 2013-11-19
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a condition, disease, or disorder in a patient implicated by CFTR wherein the disease or disorder is selected from cystic fibrosis, hereditary emphysema, chronic obstructive pulmonary disease (COPD), or dry-eye disease, comprising the step of administering to said patient a compound according to formula I or formula II: or a pharmaceutically acceptable salt thereof, wherein: each R the two R X is CH ring A is 3-7 membered monocyclic cycloalkyl ring; R R′ is hydrogen or C1-C6 aliphatic, wherein up to two carbon units of said aliphatic are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR—, —CONRNR—, —CO R is hydrogen or C1-C6 aliphatic; Z is an electron withdrawing substituent; and q is 0-3.