Patent ID: 6030982
Filing Date: 2000-02-29
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR325## or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c and d represents N or NR.sup.9 wherein R.sup.9 is O.sup.-, --CH.sub.3 or --(CH.sub.2).sub.n CO.sub.2 H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR.sup.1 or CR.sup.2 ; orR.sup.1, R.sup.3, and R.sup.4 are independently selected from halo;R.sup.2 is H;R.sup.5, R.sup.6, R.sup.7 and R.sup.8 each independently represents H, --CF.sub.3, --COR.sup.10, alkyl or aryl, said alkyl or aryl optionally being substituted with --OR.sup.10, --SR.sup.10, --S(O).sub.t R.sup.11, --NR.sup.10 COOR.sup.11, --N(R.sup.10).sub.2, --NO.sub.2, --COR.sup.10, --OCOR.sup.10, --OCO.sub.2 R.sup.11, --CO.sub.2 R.sup.10, OPO.sub.3 R.sup.10, or R.sup.5 is combined with R.sup.6 to represent .dbd.O or .dbd.S and/or R.sup.7 is combined with R.sup.8 to represent .dbd.O or .dbd.S;R.sup.10 represents H, alkyl, aryl, or aralkyl;R.sup.11 represents alkyl or aryl;X represents CH or C, wherein X is CH, the optional double bond (represented by the dotted line) to carbon atom 11 is absent; when X is C, the optional double bond is present;the dotted line between carbon atoms 5 and 6 represents an optional double bond, such that when a double bond is present, A and B independently represent --R.sup.10, halo, --OR.sup.11, --OCO.sub.2 R.sup.11 or --OC(O)R.sup.10, and when no double bond is present between carbon atoms 5 and 6, A and B each independently represent H.sub.2, --(OR.sup.11).sub.2 ; H and halo, dihalo, alkyl and H, (alkyl).sub.2, --H and --OC(O)R.sup.10, H and --OR.sup.10, .dbd.O, aryl and H, .dbd.NOR.sup.10 or --O-- (CH.sub.2).sub.p --O-- wherein p is 2, 3 or 4; andW represents: ##STR326## wherein: R.sup.12 is selected from the group consisting of: (a) H; (b) alkyl; (c) aralkyl; and (d) heteroarylalkyl;R.sup.13 and R.sup.14 are each independently selected from the group consisting of: (a) H; (b) --C(O)OR.sup.16 wherein R.sup.16 represents alkyl, aralkyl, and heteroaralkyl; (c) --SO.sub.2 R.sup.17 wherein R.sup.17 is selected from the group consisting of: NH.sub.2, --N(alkyl).sub.2 wherein each alkyl is the same or different, alkyl, aryl, aralkyl, heteroaryl and helieroaralkyl; (d) --C(O)R.sup.18 wherein R.sup.18 is selected from the group consisting of: aryl, alkyl, aralkyl, heteroaryl, and heteroaralkyl; (e) C.sub.1-6 alkyl; (f) alkaryl; and (g) C.sub.3-6 cycloalkyl; andr is 0, 1 or 2.