Patent ID: 6537994
Filing Date: 2003-03-25
Classification: C07D

Abstract:
A compound of formula I having the structure (a) a phenyl ring substituted with (R1)m; (b) a naphthyl ring substituted with (R1)m; or (c) a phenyl fused heterocycle selected from the group consisting of U is â€”OCH2â€” or a bond; V is O or a bond; W is T is CH or N; R1 is alkyl of 1-8 carbon atoms, aryl of 6-10 carbon atoms, â€”OR7, cycloalkyl of 3-8 carbon atoms, halogen, cyano, trifluoromethyl, CO2R7, NHCOR7, NHSO2R7, â€”NR7CONR8R9, â€”NR7R8, alkenyl of 2-7 carbon atoms, S(O)vR7, NO2, â€”O(CH2)uCO2R7, â€”OCONR7R8, â€”O(CH2)sOR7, or a 5-6 membered heterocyclic ring containing 1 to 4 heteroatoms selected from O, S, and N; R2, R4, R7, R8, and R9 are each, independently, hydrogen, alkyl of 1-8 carbon atoms, aryl of 6-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, or arylalkyl having 1-8 carbon atoms in the alkyl moiety; R3 is hydrogen, nitro, halogen, or â€”NR10R11; R5 is hydrogen; alkyl of 1-8 carbon atoms; alkenyl of 2-7 carbon atoms; arylalkyl having 1-8 carbon atoms in the alkyl moiety; alkyl of 1-8 carbon atoms, substituted with 1-4 substituents selected from â€”OR7 and halogen; â€”(CH2)qCR12R13(CH2)rR7; aryl of 6-10 carbon atoms, optionally mono-, di-, or tri-substituted with a substituent selected from the group consisting of halogen, cyano, nitro, trifluoromethyl, alkyl of 1-8 carbons optionally substituted with 1-4 substituents selected from OR7 or halogen, cycloalkyl of 3-8 carbon atoms, aryl of 6-10 carbon atoms, â€”NHCONR7R8, and â€”CO2R7; or a 5-6 membered heterocyclic ring containing 1 to 4 heteroatoms selected from O, S, and N, which is optionally mono- or di-substituted with halogen, alkyl of 1-8 carbon atoms, or arylalkyl having 1-8 carbon atoms in the alkyl moiety; R6 is hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-7 carbon atoms, or arylalkyl having 1-8 carbon atoms in the alkyl moiety; R10 and R11 are each, independently, hydrogen, alkyl of 1-8 carbon atoms, arylalkyl having 1-8 carbon atoms in the alkyl moiety, â€”COR7, or â€”CONR7R8; R12 and R13 are each, independently, hydrogen, alkyl of 1-8 carbon atoms, or aryl of 6-10 carbon atoms which is optionally substituted with alkyl of 1-8 carbon atoms or halogen; or R12 and R13 are taken together to form a spiro fused cycloalkyl ring of 3-8 carbon atoms; m=0-2; q=0-5; r=0-5; s=1-4; u=1-4; v=0-2; or a pharmaceutically acceptable salt thereof.