Patent ID: 8884026
Filing Date: 2014-11-11
Classification: A61K,A61P,C07D

Abstract:
1. A process for preparing rufinamide which comprises the one-pot process for the preparation of a compound of formula 1H-I said process comprising the steps of: a) reacting a compound of formula IX with sodium azide in the presence of a phase transfer catalyst and a non polar solvent or a dipolar aprotic solvent having a boiling point below about 100° C., wherein LG is a leaving group; b) reacting the resulting mixture with propiolic acid; c) isolating the compound of formula 1H-I, wherein the compound of formula 1H-I comprises an 3H-I isomer of the formula in an amount less than about 0.2 area-% as measured by a chromatographic method, and d) activating the compound of formula 1H-I in the form of an acid halide; e) reacting the produce of step d) with ammonia ore a solution comprising ammonia; and f) isolating the rufinamide.