Patent ID: 6610852
Filing Date: 2003-08-26
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula wherein R1, R1â€², R5, and R5â€² are independently selected from the group consisting of (CH2)nX wherein n is between 0 and 6 and X is H, OH, SH, COOH or NH2; and mono-, di-, or tri-halogenated C1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkenyl; with the proviso that at least one R1, R1â€², R5, and R5â€² is selected from the group consisting of OH, SH, and NH2; wherein R2, R2â€², R4 and R4â€² are independently selected from the group consisting of (CH2)nZ, wherein n has the meaning given above and Z is H, OH, SH, COOH, or NH2; and mono-, di-, or tri-halogenated C1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkenyl; wherein R3 and R3â€² are independently selected from the group consisting of H and mono-, di-, or tri-halogenated C1-6 alkyl, or are absent; wherein R6 and R6â€² are (CH2)x, wherein x is between 1 and 6; wherein R7 is selected from NH and HOP&boxH;O; or wherein R6, R6â€², and R7 combine to form an aryl group, heteroaryl group, or or a pharmaceutically acceptable salt thereof; wherein the compound is not dipyridoxylamine; and wherein if R7 is NH, R6 and R6â€² are CH2, and one of R5 or R5â€² is OH, then the other of R5 and R5â€² is selected from the group consisting of (CH2)nX wherein n is between 0 and 1 and X is H, OH, SH, COOH or NH2; and mono-, di-, or tri-halogenated C 1-6 alkoxy, or C 1-6 alkenyl.