Patent ID: 6391878
Filing Date: 2002-05-21
Classification: A61P,C07D

Abstract:
A compound of formula: wherein:a) R1 is hydrogen; or alkyl or nil; where R1 is nil, bond (a) is a double bond; b) D is CR2 and R2 is selected from hydrogen; unsubstituted C1-C3 alkanyl; amino, hydroxy, mercapto; C1-C3 alkylthio or alkoxy; C1-C3 alkylamino or C1-C3 dialkylamino and halo; c) B is CR3=CR8 or CR3=N wherein R3 and R8 are each independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo; d) R4, R5, and R6 are each independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cyclalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino; halo; and NHâ€”C(=NR10)NHR11 (guanidinyl); wherein R10 and R11 are independently selected from hydrogen; methyl; and ethyl; and wherein one and only one of R4, R8, and R6 is guanidinyl; e) R1 is hydrogen or alkyl when B is CR3=CR8 and R4 or R5 is guanidinyl, and B is CR3=N and R6 is guanidinyl; f) R7 is selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkythio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo; or its enantiomer, optical isomer, stereoisomer, diastereomer, tautomer, addition salt, or biohydrolyzable amide or ester.