Patent ID: 8957193
Filing Date: 2015-02-17
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polynucleotide encoding an antibody, or antigen-binding fragment thereof, that binds to CD40, wherein said antibody, or antigen-binding fragment thereof, comprises (i) a heavy chain variable region comprising the VHCDR1, VHCDR2, and VHCDR3 set forth in SEQ ID NOs:3-5; and (ii) a light chain variable region comprising the VLCDR1, VLCDR2, and VLCDR3 set forth in SEQ ID NOs:6-8; or a variant of said antibody, or antigen-binding fragment thereof, comprising heavy and light chain variable regions identical to the heavy and light chain variable regions of (i) and (ii) except for up to 8 amino acid substitutions in said CDR regions.