Patent ID: 8133862
Filing Date: 2012-03-13
Classification: A61K,A61P,G01N

Abstract:
1. A method for treating a human pediatric subject having secondary insulin-like growth factor-1 deficiency (IGFD), the method comprising; administering to the human pediatric subject an effective amount of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), wherein the subject is characterized as follows: a) at the time of treatment or prior to initial treatment with IGF-1, has or had a height at least about 2 standard deviations (SD) below the normal mean height for a human pediatric subject of the same age and gender, b) at the time of treatment or prior to initial treatment with IGF-1, has or had a blood level of IGF-1 at least about 1 SD below normal mean levels for a human pediatric subject of the same age and gender, c) the human pediatric subject does not have Laron syndrome or partial growth hormone insensitivity syndrome, and d) the subject has a blood level of growth hormone binding protein (GHBP) which is at least normal for a subject of the same age and gender, wherein said administering is effective to treat secondary IGFD in the human pediatric subject.