Patent ID: 7342124
Filing Date: 2008-03-11
Classification: C07D,C07F

Abstract:
1. A process for preparing a compound of formula I: wherein: R R R R each R Q is H or an acid labile hydroxyl protecting group wherein the hydroxyl protecting group has a mass of 135 Daltons or less and is unbranched at the atom bonded to the oxygen of the hydroxyl group being protected; and X is halogen; comprising contacting a compound of formula II: wherein: R R R R Q is H or an acid labile hydroxyl protecting group wherein the hydroxyl protecting group has a mass of 135 Daltons or less and is unbranched at the atom bonded to the oxygen of the hydroxyl group being protected; and X is halogen; at a pressure of less than about 10,000 psi with a phosphine of formula P(R 9 ) 3 wherein each R 9 is independently C 6-14 aryl; for a time and under conditions sufficient to prepare the compound of formula I.