Patent ID: 9029511
Filing Date: 2015-05-12
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of therapeutically treating a mammal having a cancerous tumor comprising a cell that expresses a polypeptide comprising the sequence of SEQ ID NO:2, the method comprising administering to the mammal a therapeutically effective amount of an antibody drug conjugate having the formula: or a pharmaceutically acceptable salt or solvent thereof, wherein Ab is an antibody that binds a polypeptide comprising the sequence of SEQ ID NO:2, wherein the antibody comprises three light chain complementary determining regions (CDR-L1, CDR-L2 and CDR-L3) and three heavy chain CDRs (CDR-H1, CDR-H2 and CDR-H3), wherein (a) CDR-L1 comprises the sequence of SEQ ID NO: 23; (b) CDR-L2 comprises the sequence of SEQ ID NO: 36; (c) CDR-L3 comprises the sequence of SEQ ID NO: 41; (d) CDR-H1 comprises the sequence of SEQ ID NO: 43; (e) CDR-H2 comprises the sequence of SEQ ID NO: 49; and (f) CDR-H3 comprises the sequence of SEQ ID NO: 65; L is a linker; D is a drug moiety; and P is 1 to about 20.