Patent ID: 6166288
Filing Date: 2000-12-26
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
A method of preparing organs, tissues, or cells for xenotransplantation into human patients with reduced rejection comprising the steps of:(a) providing a transgenci pig which is a source of transplant material which is anatomically and physiologically compatible with a human patient, said material selected from the group consisting of organs, tissues, or cells, said pig expressing(i) at least one transgenically encoded enzyme, functional in said pig, and in particular in said organs, tissues, or cells, that masks or reduces the level of a zenoreactive antigen of said transplant material, said at least one enzyme being a fucosyltransferase, and(ii) at least one transgenically encoded complement inhibitor functional in humans; and(b) isolating said transplant material from said transgenic pig, said material having been modified by said enzyme, wherein said modification results in a masking or a reduction in the level of a zenoreactive antigen thereof, said material further being associated with said complement inhibitor.