Patent ID: 6936466
Filing Date: 2005-08-30
Classification: A61K,C07K,C12N

Abstract:
1. A polynucleotide comprising a region containing an Adeno-associated virus (AAV) inverted terminal repeat (ITR) and one or more heterologous transcriptionally active elements incorporated 3′ with respect to the ITR, wherein the transcriptional activity is increased at least about two-fold relative to a polynucleotide containing the ITR and lacking the one or more heterologous transcriptionally active elements under conditions permissive for transcription, wherein at least one of the one or more heterologous transcriptionally active elements is a transcriptionally active element from a human gene, and wherein the region containing the ITR and the one or more transcriptionally active elements is less than about 400 nucleotides in length.