Patent ID: 7045131
Filing Date: 2006-05-16
Classification: A61K,C07K

Abstract:
1. A method of obtaining a purified human donor immunoglobulin composition comprising an antibody titer to an S. aureus serine-aspartate repeat (Sdr) protein in combination with an antibody titer to an S. epidermidis serine-asparate repeat (Sdr) protein wherein both antibody titers are higher than that found in pooled intravenous immunoglobulin obtained from unselected human donors, said method comprising obtaining blood or plasma samples from human donors, screening said samples so as to select those samples having an antibody titer to an S. aureus Sdr protein and an antibody titer an S. epidermidis Sdr protein that are both in an amount that is higher than that found in pooled intravenous immunoglobulin obtained from unselected donors, recovering blood or plasma from the selected high-titer donors, and treating the donor blood plasma to obtain immunoglobulin in a purified state having an antibody titer to an S. aureus Sdr protein and an antibody titer to an S. epidermidis Sdr protein that are both in an amount which is higher than that found in pooled intravenous immunoglobulin obtained from unselected human donors.