Patent ID: 8629261
Filing Date: 2014-01-14
Classification: A01K,A61K,C07K,C12N

Abstract:
1. An isolated polynucleotide comprising OLIG1 regulatory elements, having at least 95% sequence identity to SEQ ID NO: 2, 3 and 4, wherein the sequence elements at SEQ ID NO: 2 residues 37-48; residues 89-110; residues 138-164; residues 184-259; residues 288-661; residues 683-857; residues 880-892 are conserved and present in said polynucleotide; the sequence elements at SEQ ID NO:3, residues 33-51; residues 124-145; residues 170-212 are conserved and present in said polynucleotide; the sequence elements at SEQ ID NO:4 residues 238-257; residues 311-859; residues 916-989; residues 1000-1012; residues 1037-1067 are conserved and present in said polynucleotide; operably joined to an OLIG1 basal promoter having at least 95% sequence identity to SEQ ID NO:5 wherein the sequence elements at SEQ ID NO:5, residues 267-277; residues 340-353; and residues 409-426 are conserved and present in said polynucleotide, through a non-native spacing of not more than 1 kb between the promoter and the regulatory elements.