Patent ID: 8962017
Filing Date: 2015-02-24
Classification: A61K,A61P,Y10S

Abstract:
1. A formulation of silymarin, comprising: a silymarin solid dispersion, silymarin-loaded silica nanoparticles, a slow-release matrix material and a release enhancer, wherein a mass ratio of the silymarin solid dispersion:the silymarin-loaded silica nanoparticles:the slow-release matrix material:the release enhancer is 1:0.5-1.25:0.1-0.3:0.1-0.3; wherein the silica nanoparticles are a mesoporous material including a plurality of pores having a diameter of 1.5 nm to 50 nm; wherein the silymarin solid dispersion contains povidone K30, soybean lecithin, acrylic resin IV, wherein a mass ratio of silymarin:povidone K30:soybean lecithin:acrylic resin IV is 1:1-3:0.3-0.8:0.2-0.5.