Patent ID: 6268395
Filing Date: 2001-07-31
Classification: A61K,A61P,C07C

Abstract:
An antiviral agent comprising as an active ingredient a phorbol derivative of formula (I): ##STR7##(wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5, independently one another, represent a hydrogen atom, an aliphatic carboxylic acid residue, or an aromatic carboxylic acid residue)having a ratio r=CC.sub.0 /IC.sub.100, i.e., ratio of concentration CC.sub.0 at which survival of MT-4 cells is decreased upon cell proliferation tests to concentration IC.sub.100 at which HIV-1-induced cytopathic effect (CPE) on MT-4 cells is inhibited by 100%, of 2 or more andhaving a protein kinase C(PKC) activation of 30% or less at a concentration of 10 ng/mL.