Patent ID: 6090404
Filing Date: 2000-07-18
Classification: A61K

Abstract:
An active substance-containing patch for the controlled release of estradiol or a pharmaceutically acceptable derivative thereof, alone or in combination with a gestagen, said patch comprising (1) a backing layer, (2) an active substance-containing reservoir connected thereto and which is produced using pressure sensitive adhesives and at least one penetration enhancer, and (3) a removable protective layer, wherein the penetration enhancer is based on polyfunctional carboxylic acids, and is selected from the group consisting of glycollic acid, mandelic acid, 2-hydroxy-cinnamic acid, 3-hydro xycinnamic acid, trans-4-methoxycinnamic acid, 2-hydroxyoctanoic acid, tropic acid, gallic acid, shikimic acid, benzylic acid, benzene-1,2,4-tricarboxylic acid, dimethyl-3-oxoglutarate, 3-methyl-2-oxo-valerianic acid, 4-methyl-2-oxo-valerianic acid, 2-oxoglutaric acid, pyruvic acid, 4-aminobutyric acid, 6-amino-hexanoic acid, 11-aminoundecanoic acid, asparaginic acid, 2-aminobenzoic acid, 3-aminobenzoic acid, 4-aminobenzoic acid, 4-amino-2-salicylic acid, 3-phenylpropionic acid, 2-phenylbutyric acid, 4-phenylbutyric acid, trans-2-dodecanedioic acid, tridecanedioic acid, tetradecanedioic acid, pentadecanedioic acid, diglycollic acid, piperidine-4-carboxylic acid, pyrazine-2-carboxylic acid, pyrazine-2,3-dicarboxylic acid, pyridine-2-carboxylic acid, nicotinic acid, pimelic acid monomethyl ester, malonic acid diamide, adipic acid diamide, pyrazine-2-carboxamide and succinic acid diamide.