Patent ID: 9206430
Filing Date: 2015-12-08
Classification: A61K,A61P,C12N

Abstract:
1. A method for inhibiting a TLR7-, TLR8- and/or TLR9-mediated immune response in a vertebrate comprising administering to the vertebrate an immune regulatory oligonucleotide (IRO) compound having the structure wherein: CG is an oligonucleotide motif that is CpG, C*pG, C*pG* or CpG*, wherein C is cytosine, C* is a pyrimidine nucleotide derivative, G is guanosine, and G* is a purine nucleotide derivative; N N N N and further provided that the compound contains less than 3 consecutive guanosine nucleotides; wherein the oligonucleotide motif would be immune stimulatory but for the one or more modified nucleoside that suppresses the activity of the oligonucleotide motif; wherein m is a number from 0 to about 30; and wherein the IRO is an antagonist of agonist of TLR7, TLR8 and/or TLR9.