Patent ID: 6277061
Filing Date: 2001-08-21
Classification: A61K,A61P

Abstract:
A method of inhibiting membrane-type matrix metalloproteinase activity in a biological system, comprising administering to the system in need thereof an MT-MMP-inhibitory amount of a tetracycline compound selected from the group consisting of:4-de(dimethylamino)tetracycline,tetracyclinonitrile,6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline,4-de(dimethylamino)-7-chlorotetracycline,4-hydroxy-4-de(dimethylamino)tetracycline,4-de(dimethylamino)-12.alpha.-deoxytetracycline,6-.alpha.-deoxy-5-hydroxy-4-de(diinethylamino)tetracycline,4-de(dimethylamino)-12.alpha.-deoxyanhydrotetracycline, and4-de(dimethylamino)minocycline.