Patent ID: 8222398
Filing Date: 2012-07-17
Classification: A61K,A61P,C07H,C12N

Abstract:
1. A chimeric immunomodulatory compound (CIC) comprising a core structure with the formula [N v ] x —S p , wherein S p is a multivalent spacer moiety covalently bonded to X independently selected nucleic acid moieties (N v ), wherein the nucleic acid moieties are between 3 and 7 nucleotides, wherein X is at least 3, wherein said multivalent spacer moiety is selected from the group consisting of a polysaccharide, glycerol, substituted glycerol, tetraaminobenzene, heptaaminobetacyclodextrin, 1,3,5-trihydroxycyclohexane, pentaerythritol, 1,3-diamino-2-propanol, substituted derivatives of 1,3,-diamino-2-propanol, [propyloxymethyl]ethyl compounds, tetraaminopentaerythritol, 1,4,8,11-tetraazacyclotetradecane, 1,4,7,10-tetraazacyclododecane, polyethyleneimino, or a 2-(hydroxymethyl)ethyl moiety, and wherein said CIC further comprises at least one additional non-nucleic acid spacer moiety.