Patent ID: 7700732
Filing Date: 2010-04-20
Classification: A61K,A61P,C07K

Abstract:
1. A method of manufacturing an albumin enriched fraction having a reduced prekallikrein activator (PKA) content consisting of: (a) reconstitution of paste V (Cohn fractionation) to form a first fraction; (b) concentrating the first fraction obtained in step (a) to obtain a concentrated fraction; (c) addition of stabilizers to the concentrated fraction to obtain a stabilized fraction; (d) pasteurizing the stabilized fraction obtained in step (c) for a time period of at least nine hours at a temperature of 58° C. to 65° C. to obtain a pasteurized fraction; (e) filling vials with the pasteurized fraction; (f) performing a second pasteurization with the filled vials of step (e); and (g) incubating the vials to obtain an albumin enriched fraction having a PKA content of less than 12 IU/ml.