Patent ID: 6777557
Filing Date: 2004-08-17
Classification: A61K,A61P,A61Q,C07D

Abstract:
A compound of the formula of whereinR1 is selected from the group consisting of H, C1-5 lower alkyl, C1-18 lower alkanoyl, and aroyl; R2 is selected from the group consisting of hydrogen and C1-6 lower alkyl; R3 is selected from the group consisting of lower alkyl, C3-C8 cycloalkyl, phenyl, 1-[(aminoiminomethyl)hydrazono]ethyl substituted phenyl, naphthyl, or the aminoalkyl groupâ€”Aâ€”NR6R7 wherein A is a straight or branched alkanediyl linker of 1-6 carbons and R6 and R7 are independently selected from the group consisting of hydrogen, C1-C6 alkyl, or C1-C6 hydroxyalkyl, or R6 and R7 taken together with the nitrogen atom form a C4-C7 heterocyclic ring optionally containing one or two additional heteroatoms selected from the group consisting of N, O or sulfur; R4 is selected from the group consisting of hydrogen, acetyl and 1-[(aminoiminomethyl)-hydrazono]ethyl; and R5 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or aminoalkyl of structure â€”Lâ€”NR8R9 wherein L is a straight or branched alkanediyl linker of 1-6 carbons and R8 and R9 are independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or R8 and R9 taken together with the nitrogen atom form a C4-C7 heterocyclic ring optionally containing one or two additional heteroatoms selected from the group consisting of N, O or sulfur; with the proviso that if R4 is hydrogen then R5 is â€”Lâ€”NR8N9 as defined above; or hydrochloride salts thereof, or other pharmaceutically acceptable salts thereof.