Patent ID: 8962037
Filing Date: 2015-02-24
Classification: A61L,A61P,C01B,C04B

Abstract:
1. A method of manufacturing dicalcium phosphate dihydrate (DCPD) ceramic, dicalcium phosphate anhydrous (DCPA) ceramic, DCPD/hydroxyapatite (HA) biphasic ceramic, or DCPA/HA biphasic ceramic, comprising steps of: forming a mixture containing an acidic phosphate compound selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, phosphoric acid and a combination thereof, with a basic calcium phosphate compound comprising sintered HA; adding pure water without organic solvent or salts to the mixture so that the acidic phosphate compound reacts with the basic calcium phosphate compound to form paste of DCPD ceramic, DCPA ceramic, DCPD/HA biphasic ceramic or DCPA/HA biphasic ceramic; shaping the paste to a desired shape and hardening the paste to obtain a solid material; washing and leaching the solid material until a surface pH of the solid material reaches about 4.5 or higher; and drying the solid material at room temperature or below 95° C. to obtain DCPD ceramic or DCPD/HA biphasic ceramic, or drying the solid material at 100° C. or higher to obtain DCPA ceramic or DCPA/HA biphasic ceramic; wherein when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD ceramic or the DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA biphasic ceramic or the DCPA/HA biphasic ceramic.