Patent ID: 6326392
Filing Date: 2001-12-04
Classification: A61K

Abstract:
A method of providing contraception which comprises administering to a female of childbearing age a contraceptive effective amount of a combination of a non-uterotropic anti-estrogen of formulas I or II having the structure ##STR65##wherein:R.sub.1 is H, OH, carboalkoxy of 2-12 carbon atoms, alkoxy of 1-12 carbon atoms, halogen or mono- or poly-fluoroalkoxy of 1-12 carbon atoms;R.sub.2 is H, OH, carboalkoxy of 2-12 carbon atoms, alkoxy of 1-12 carbon atoms, halogen, mono- or poly-fluoroalkoxy of 1-12 carbon atoms, cyano, alkyl of 1-6 carbon atoms, or trifluoromethyl, with the proviso that, when R.sub.1 is H, R.sub.2 is not OH,R.sub.3 and R.sub.4 are each, independently, H, OH, carboalkoxy of 2-12 carbon atoms, alkoxy of 1-12 carbon atoms, halogen, mono- or poly-fluoroalkoxy of 1-12 carbon atoms, or cyano, with the proviso that, when R.sub.1 is H, R.sub.2 is not OH,X is H, alkyl of 1-6 carbon atoms, cyano, nitro, triflouromethyl, or halogen;n is 2 or 3;Y is a saturated, partially saturated or unsaturated 5-7 membered heterocycle containing a nitrogen, which may optionally contain a second heteroatom selected from the group consisting of --O--, --NH--, alkylamine of 1-6 carbon atoms, --N.dbd., and S(O).sub.m ;m is 0-2;or a pharmaceutically acceptable salt thereof,and a progestin for 28 consecutive days per 28-day menstrual cycle.