Patent ID: 6465459
Filing Date: 2002-10-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (IV): whereinZ1 is â€”Oâ€”, â€”N(R8)â€”, â€”Sâ€”, or â€”CH2Oâ€”; Z2 is â€”Oâ€”, â€”N(R8)â€”, â€”Sâ€”, or â€”OCH2â€”; R2 is hydrogen; halo; alkyl; haloalkoxy; â€”OR8; â€”C(O)OR8; â€”C(O)N(R8)R9; â€”N(R8)R9; â€”C(O)N(R8)(CH2)mC(O)OR8 (where m is 0 to 3); â€”N(R8)(CH2)nC(O)OR8 (where n is 1 to 3); â€”N((CH2)nN(R8)R9)(CH2)nC(O)OR8 (where each n is 1 to 3); â€”O(CH2)nC(O)N(R8)R9 (where n is 1 to 3); â€”O(CH2)pC(O)OR8 (where p is 1 to 6); â€”N(R8)(CH2)nC(O)N(R8)(CH2)nC(O)OR8 (where each n is independently 1 to 3); morpholin-4-yl; 3-tetrahydrofuranoxy; or R2 is aryloxy (optionally substituted by one or more substituents independently selected from the group consisting of â€”OR8, â€”C(O)N(R8)R9, halo, alkyl, carboxy, alkoxycarbonyl, haloalkoxy, haloalkoxycarbonyl, alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, (alkylamino)carbonylalkyl, (dialkylamino)carbonylalkyl, (arylamino)carbonylalkyl, (aralkylamino)carbonylalkyl, alkoxycarbonylalkenyl, carboxyalkenyl, aminocarbonylalkenyl, (alkylamino)carbonylalkenyl, (dialkylamino)carbonylalkenyl, (arylamino)carbonylalkenyl, (aralkylamino)carbonylalkenyl, (hydroxyalkoxy)carbonyl, (alkoxy)alkoxycarbonyl, (hydroxyalkoxy)alkoxycarbonyl, ((alkoxy)alkoxy)alkoxycarbonyl, tetrazolyl, morpholin-4-ylalkyl, and (1,2)-imidazolinyl (optionally substituted by alkyl)); or R2 is piperazin-1-yl (optionally substituted by one or more substituents independently selected from the group consisting of alkyl, carboxy, â€”C(O)N(R8)R9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl); or R2 is 1-piperazinoyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, carboxy, â€”C(O)N(R8)R9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl); or R2 is piperidin-1-yl (optionally substituted by one or more substituents selected from the group consisting of carboxy, â€”C(O)N(R8)R9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl); or R2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkylcarbonyl, carboxy, â€”C(O)N(R8)R9, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, and tetrazolylalkyl); or R2 is piperidin-4-ylamino (wherein the amino is optionally substituted by alkyl and the piperidinyl group is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxycarbonyl, carboxyalkyl, â€”C(O)N(R8)R9, alkoxycarbonylalkyl and aralklyl); or R2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, amidino, 1-iminoethyl, carboxy, carboxyalkyl, â€”C(O)N(R8)R9, alkoxycarbonyl and alkoxycarbonylalkyl); R4 and R7 are independently hydrogen, halo, alkyl, nitro, â€”OR8, â€”C(O)OR8, â€”C(O)N(R8)R9, â€”N(R8)R9, â€”N(H)C(O)R8, or â€”N(H)S(O)2R12; R5 is â€”C(NH)NH2, â€”C(NH)N(H)OR8, â€”C(NH)N(H)C(O)OR12, â€”C(NH)N(H)S(O)2R12, â€”C(NH)N(H)C(O)N(R8)R9, or â€”C(NH)N(H)C(O)R8; R6 is halo, alkyl, haloalkyl, haloalkoxy, nitro, amino, ureido, guanidino, â€”OR8, â€”C(NH)NH2, â€”C(NH)NHOH, â€”C(O)R10, â€”(CH2)mC(O)N(R8)R9 (where m is 0 to 3), â€”CH(OH)C(O)N(R8)R9, â€”(CH2)mN(R8)R9 (where m is 0 to 3), â€”(CH2)mC(O)OR8 (where m is 0 to 3), â€”N(H)C(O)R8, (1,2)-tetrahydropyrimidinyl (optionally substituted by alkyl), (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl); each R8 and R9 are independently hydrogen, alkyl, aryl, or aralkyl; R10 is hydrogen, alkyl, aryl, aralkyl, 1-pyrrolidinyl, 4-morpolinyl, 4-piperazinyl, 4-(N-methyl)piperazinyl, or piperidin-1-yl; and R12 is alkyl, aryl or aralkyl; or a pharmaceutically acceptable salt thereof.