Patent ID: 6515005
Filing Date: 2003-02-04
Classification: A61P,C07D

Abstract:
A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof whereinX is O, S, NH or Nâ€”C1-6alkyl; W and Wâ€² are each H; Z and Zâ€² are independently CH or N â€ƒprovided that if Zâ€² is N, then Z is CH; if Z is N, then Zâ€² is CH; R1 and R2 are each the same or different and selected from the group consisting of H, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C3-7cycloalkyl, C1-6alkyl-C3-7cycloalkyl, C2-6alkenyl, C3-6alkynyl, C1-6cyanoalkyl, C1-6aralkyl, 5 or 6-membered heterocycle and 9 or 10-membered bicyclic fused heterocycle; â€ƒwherein said C1-6aralkyl is optionally substituted with one or more of the same or different halogens or with one or more of the same or different C1-4alkoxy groups; said 5 or 6-membered heterocycle contains one to three of the same or different heteroatoms selected from the group consisting of O, N and S and said 5 or 6-membered heterocycle is optionally substituted with C1-4alkyl, C1-4thioalkyl, C1-4haloalkyl, halo, cyano or â€”Oâ€”C1-4alkyl; â€ƒprovided that if three of said heteroatoms are contained in said 5-membered heterocycle, said three heteroatoms are not all the same heteroatoms; said 9 or 10-membered bicyclic fused heterocycle contains one to three of the same or different heteroatoms selected from the group consisting of O, N and S; R1 and R2 together with the nitrogen to which they are attached form a five or six-membered heterocycle, said heterocycle containing one to three of the same or different heteroatoms selected from the group consisting of N, S or O; and said heterocycle optionally substituted with one or more C1-6alkyl, â€”C1-6alkyl-C1-6alkoxy or C1-6alkoxy groups; R3 is C1-6alkyl, C1-6haloalkyl, halo, cyano or C1-6alkoxy; R4 is H or C1-6alkyl; R5 is H, C1-6alkyl or halo; R6 is C1-6alkyl or halo; and R7 is H, C1-6alkyl or halo; â€ƒprovided that if R5 is H, then R7 is not H; and if R7is H, then R5 is not H.