Patent ID: 8969005
Filing Date: 2015-03-03
Classification: C07K,C12Q,G01N

Abstract:
1. A diagnostic kit for predicting an increased risk of an individual for developing amyotrophic lateral sclerosis (ALS) disease, consisting of an isolated detectably labeled nucleic acid that specifically hybridizes to a mutated TAF15 encoding nucleic acid, wherein the mutated TAF15 encoding nucleic acid comprises a mutation selected from the group consisting of: i. a missense G>A mutation in exon 14 causing a Gly391Glu alteration; and ii. a missense C>T mutation in exon 15 causing a Arg408Cys alteration relative to wild-type TAF15 encoding nucleic acids; wherein said label is selected from the group consisting of an antibody, a product that produces a reporter signal, and a marker, each being suitable for detecting said mutated TAF 15 encoding nucleic acid.