Patent ID: 6706283
Filing Date: 2004-03-16
Classification: A61K

Abstract:
A controlled release dosage form, comprising:(a) a core comprising an osmotic agent and a low solubility drug in the form of a solid dispersion of said drug in a dispersion polymer, at least a major portion of said drug being amorphous; (b) a water-permeable coating around said core having at least one delivery port therein, said coating controlling the influx of water to said core from an aqueous environment of use to cause extrusion of at least a portion of said core through said at least one delivery port to said aqueous environment of use, said coating being non-dissolving and non-eroding during release of said drug; wherein said osmotic agent comprises a water-swellable hydrophilic polymer that is separate from said dispersion polymer; wherein said dosage form provides an AUC in a use environment that is at least 1.25-fold that of a control dosage form comprising an identical dosage form containing an equivalent quantity of undispersed drug; and wherein said drug in said solid dispersion exhibits non-crystalline character in x-ray diffraction analysis.