Patent ID: 9108915
Filing Date: 2015-08-18
Classification: C07B,C07C,C07D,Y02P

Abstract:
1. A method for producing an optically active anti-4-hydroxypyrrolidine-3-carboxamide compound represented by formula (II) or its enantiomer, wherein PG the method comprising: subjecting a 4-oxopyrrolidine-3-carboxamide compound represented by formula (I) to an asymmetric hydrogenation using an optically active catalyst having a chiral ligand under a hydrogen pressure of from 0.1 MPa to less than 1 MPa, wherein the chiral ligand is selected from the group consisting of (i) an optionally active 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP), (ii) 5,5′-bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxle (SEGPHOS), (iii) (2,2′-bisdiphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl (MeO-BIPHEP), and (iv) (S)-(−)-2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl ((S)-TolBINAP) (Step A), wherein PG