Patent ID: 6372767
Filing Date: 2002-04-16
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula: wherein,Ar1 is substituted phenyl bearing a substituent selected from the group consisting of halogen, alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, nitro, cyano, â€”NR7R8, phenyl and substituted phenyl, R7 and R8 are members independently selected from the group consisting of hydrogen, (C1-C8)alkyl, substituted (C1-C8)alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl and substituted aryl(C1-C4)alkyl, or R7 and R8 taken together with the nitrogen to which each is attached form a 5-, 6- or 7-membered ring optionally having additional heteroatoms at the ring vertices; X is a member selected from the group consisting of O, S and Nâ€”R1, wherein, R1 is a member selected from the group consisting of H, (C1-C8)alkyl, substituted (C1-C8)alkyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl, substituted aryl (C1-C4)alkyl, CN, â€”C(O)R2, â€”OR3, â€”C(O)NR3R4, and â€”S(O)2NR3R4, wherein, R2 is a member selected from the group consisting of (C1-C8)alkyl, substituted (C1-C8)alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, alkaryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl and substituted aryl(C1-C4)alkyl; R3 and R4 are each members independently selected from the group consisting of hydrogen, (C1-C8)alkyl, substituted (C1-C8)alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl and substituted aryl(C1-C4)alkyl, or R3 and R4 can be combined with the nitrogen to which each is attached to form a 5-, 6- or 7-membered ring optionally having additional heteroatoms at the ring vertices; and Y is a member selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 substituted alkyl, â€”OCH3 and â€”OCF3.