Patent ID: 6503752
Filing Date: 2003-01-07
Classification: A61K,C07K,C12N

Abstract:
A recombinant DNA molecule comprising:(a) a DNA sequence encoding HHV-6 or HHV-7, said DNA sequence encoding HHV-6 or HHV-7 comprising an origin of replication, a promoter sequence which induces expression in a T-cell host and a cleavage and packaging signal; and (b) a foreign nucleic acid sequence selected from the group consisting of a sequence coding for Thymidine Kinase, a sequence coding for glucocerebrosidase, a sequence coding for an insulin growth factor, a sequence coding for an insulin-like growth factor, a sequence coding for a protein which inhibits proliferation of malignant cells, a sequence coding for a protein which protects non-malignant cells from toxic effects of radiation, a sequence coding for a protein which protects non-malignant cell from toxic effects of chemotherapeutic agents, and combinations thereof.