Patent ID: 6747150
Filing Date: 2004-06-08
Classification: A61K,A61P,C07F,C07K

Abstract:
A compound having the formula (1a) or a pharmaceutically acceptable salt thereof; whereinP is R7â€”C(O)â€”, where R7 is heteroaryl or heteroarylalkyl; X2 is â€”C(O)â€”NHâ€”; R is hydrogen or alkyl, or R forms together with the adjacent R1, or when A is zero, forms together with the adjacent R2, a nitrogen-containing mono-, bi- or tri-cyclic, saturated or partially saturated ring system having 4-14 ring members, that can be optionally substituted by one or two of keto, hydroxy, alkyl, aryl, aralkyl, alkoxy or aryloxy; R1, at each occurrence, is independently one of hydrogen, alkyl, cycloalkyl, aryl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or â€”CH2â€”R5, where the ring portion of any of said aryl, aralkyl, alkaryl or heterocycle can be optionally substituted; R2 is one of hydrogen, alkyl, cycloalkyl, aryl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or â€”CH2â€”R5, where the ring portion of any of said aryl, aralkyl, alkaryl or heterocycle can be optionally substituted; R3 is one of hydrogen, alkyl, cycloalkyl, aryl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or â€”CH2â€”R5, where the ring portion of any of said aryl, aralkyl, alkaryl or heterocycle can be optionally substituted; R5, in each instance, is one of aryl, aralkyl, alkaryl, cycloalkyl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or â€”Wâ€”R6, where W Is a chalcogen and R6 is alkyl, where the ring portion of any of said aryl, aralkyl, alkaryl or heterocycle can be optionally substituted; Z1 and Z2 are independently one of alkyl, hydroxy, alkoxy, or aryloxy, or together Z1 and Z2 form a moiety derived from a dihydroxy compound having at least two hydroxy groups separated by at least two connecting atoms in a chain or ring, said chain or ring comprising carbon atoms, and optionally, a heteroatom or heteroatoms which can be N, S, or 0; and A is zero.