Patent ID: 6083955
Filing Date: 2000-07-04
Classification: A61P,C07D

Abstract:
An arylethenesulfonamide compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: ##STR20## in which Ar is a thienyl group or an aryl group which is unsubstituted or substituted with one to five identical or different substituents selected from the group consisting of lower alkyl group, lower alkoxy group, lower alkoxycarbonyl group, carboxyl group, halogen atom, nitro group, cyano group, amino group, mono-lower alkylamino group, di-lower alkylamino group, hydroxyl group and C.sub.1-3 alkylenedioxy group, wherein said lower alkyl group is unsubstituted or substituted with one to four identical or different substituents selected from the group consisting of halogen atom, lower alkoxy group, carboxyl group, amino group, mono-lower alkylamino group, and di-lower alkylamino group;X is oxygen atom, sulfur atom or a group represented by --NH--;Y is oxygen atom or sulfur atom;R.sub.1 is hydrogen atom, lower alkyl group which is unsubstituted or substituted with one or more identical or different halogen atoms, cycloalkyl group, aryl group which is unsubstituted or substituted with one to five identical or different substituents selected from the group consisting of lower alkyl group, lower alkoxy group, lower alkoxycarbonyl group, carboxyl group, halogen atom, nitro group, cyano group, amino group, mono-lower alkylamino group, di-lower alkylamino group, hydroxyl group and C.sub.1-3 alkylenedioxy group, wherein said lower alkyl group is unsubstituted or substituted with one to four identical or different substituents selected from the group consisting of halogen atom, lower alkoxy group, carboxyl group, amino group, mono-lower alkylamino group, and di-lower alkylamino group, or five- to six-membered heteroaryl group selected from the group consisting of pyrimidinyl, pyridinyl, thienyl, thiazolyl, 1,3-benzodioxanyl and furyl, wherein said heteroaryl group is unsubstituted or substituted with one to four identical or different substituents selected from the group consisting of lower alkyl group, lower alkoxy group, lower alkoxycarbonyl group, carboxyl group, halogen atom, nitro group, cyano group, amino group, mono-lower alkylamino group, and di-lower alkylamino group, wherein said lower alkyl group is unsubstituted or substituted with one to four identical or different substituents selected from the group consisting of halogen atom, lower alkoxy group, carboxyl group, amino group, mono-lower alkylamino group, and di-lower alkylamino group;R.sub.2 is lower alkyl group, lower alkenyl group or lower alkynyl group, and R.sub.2 is unsubstituted or substituted with one to three identical or different substituents selected from the group consisting of hydroxyl group, lower alkoxy group, cycloalkyl group, halogen atom, carboxyl group and lower alkoxycarbonyl group;R.sub.3 is phenyl group which is unsubstituted or substituted with one to four identical or different substituents selected from the group consisting of lower alkyl group which is unsubstituted or substituted with one or more identical or different halogen atoms, lower alkoxy group, halogen atom, lower alkylthio group, lower alkylsulfinyl group, lower alkanesulfonyl group, carboxyl group, lower alkoxycarbonyl group and carbamoyl group; andR.sub.4 and R.sub.5 are the same or different and each is hydrogen atom or lower alkyl.