Patent ID: 6675105
Filing Date: 2004-01-06
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
A method of structure-based identification of candidate compounds for binding to Fc receptor (FcR) proteins, comprising:(a) constructing a three dimensional structure of an FcR protein using as a template a three dimensional structure of an Fc&ggr;RIIa protein defined by atomic coordinates represented in a table selected from the group consisting of Table 1 and Table 2; (b) performing computer-assisted, structure based drug design with said structure of (a); and (c) identifying at least one candidate compound structure that is predicted to have a compatible conformation with a target site on the constructed structure of the FcR protein such that the compound having the compound structure is predicted to bind to the FcR protein.