Patent ID: 6063786
Filing Date: 2000-05-16
Classification: C07D

Abstract:
A compound represented by formula (I): ##STR4## wherein each R.sup.1 is independently H or a substituent (optionally substituted with R.sup.10) selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, C.sub.1-6 alkyl-aryl, furanyl, thiophenyl, pyridyl, indolyl, quinolyl, C.sub.1-6 alkyl-heteroaryl, azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, indolinyl, tetrahydroquinolinyl, C.sub.1-6 alkyl-heterocycloalkyl, cycloalkyl and C.sub.1-6 alkyl-cycloalkyl;each R.sup.2 is independently H or C.sub.1-6 alkyl;or either or each of R.sup.1 R.sup.2 may alternatively represent cycloalkyl or azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, indolinyl, tetrahydroquinolinyl, optionally substituted with R.sup.10 or a substituent (optionally substituted with R.sup.10) selected from the group consisting of C.sub.1-6 alkyl, aryl, furanyl, thiophenyl, pyridyl, indolyl, quinolyl, C.sub.1-6 alkyl-heteroaryl and C.sub.1-6 alkyl-aryl; ##STR5## R.sup.5 is selected from the group consisting of C.sub.1-6 alkyl-aryl, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, cycloalkenyl, C.sub.1-6 alkyl-cycloalkenyl, heterocycloalkenyl, C.sub.1-6 alkyl-heterocycloalkenyl, C.sub.1-6 alkyl-heteroaryl, azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, indolinyl, tetrahydroquinolinyl, C.sub.1-6 alkyl-heterocycloalkyl, aryl, furanyl, thiophenyl, pyridyl, indolyl, and quinolyl, any of which groups is optionally substituted by a substituent selected from the group consisting of R.sup.6, C.sub.1-6 alkyl-R.sup.6, aryl (optionally substituted with R.sup.6), C.sub.1-6 alkyl-aryl (optionally substituted with R.sup.6), C.sub.1-6 alkyl-heteroaryl (optionally substituted with R.sup.6), furanyl (optionally substituted with R.sup.6), thiophenyl (optionally substituted with R.sup.6), pyridyl (optionally substituted with R.sup.6), indolyl (optionally substituted with R.sup.6), quinolyl (optionally substituted with R.sup.6), cycloalkyl (optionally substituted with R.sup.6), and azetidinyl (optionally substituted with R.sup.6), pyrrolidinyl (optionally substituted with R.sup.6), tetrahydrofuranyl (optionally substituted with R.sup.6), piperidinyl (optionally substituted with R.sup.6), indolinyl (optionally substituted with R.sup.6), tetrahydroquinolinyl (optionally substituted with R.sup.6), and each instance of R.sup.5 may be the same or different;R.sup.6 is selected from the group consisting of halogen, CN, NO.sub.2, N(R.sup.7).sub.2, OR.sup.7, NR.sup.7 R.sup.8, S(O).sub.1-2 R.sup.9, SO.sub.2 N(R.sup.7).sub.2, CO.sub.2 R.sup.11, CON(R.sup.7).sub.2, COR.sup.7, CONR.sup.11 OR.sup.7, and C.sub.1-6 alkyl;R.sup.7 is H or a substituent selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, furanyl, thiophenyl, pyridyl, indolyl, quinolyl, C.sub.1-6 alkyl-heteroaryl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, indolinyl, tetrahydroquinolinyl and C.sub.1-6 alkyl-heterocycloalkyl, wherein said substituent is optionally substituted with a substituent selected from the group consisting of R.sup.9, COR.sup.9, SO.sub.0-2, R.sup.9, CO.sub.2 R.sup.9, OR.sup.9, SH, OH, SCOR.sup.9, CONR.sup.11 R.sup.9, NR.sup.11 R.sup.9, halogen, CN, SO.sub.2 NR.sup.11 R.sup.9, and NO.sub.2, and for each case of N(R.sup.7).sub.2 the R.sup.7 groups are the same or different or N(R.sup.7).sub.2 is azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, indolinyl, tetrahydroquinolinyl optionally substituted with a substituent selected from the group consisting of R.sup.9, COR.sup.9, SO.sub.0-2 R.sup.9, CO.sub.2 R.sup.9, OR.sup.9, SH, OH, SCOR.sup.9, CONR.sup.11 R.sup.9, NR.sup.11 R.sup.9, CN, and SO.sub.2 NR.sup.11 R.sup.9 ;R.sup.8 is selected from the group consisting of COR.sup.7, CON(R.sup.7).sub.2, CO.sub.2 R.sup.9, and SO.sub.2 R.sup.9 ;R.sup.9 is selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, furanyl, thiophenyl, pyridyl, indolyl, quinolyl, and C.sub.1-6 alkyl-heteroaryl;R.sup.10 is selected from the group consisting of OR.sup.7, COR.sup.7, CO.sub.2 R.sup.11, CON(R.sup.7).sub.2, NR.sup.7 R.sup.8, S(O).sub.0-2 R.sup.9, SO.sub.2 N(R.sup.7).sub.2, halogen, CN, NO.sub.2, and succinimidoyl (optionally substituted with R.sup.11), phthalimidoyl (optionally substituted with R.sup.11), hydamtionyl (optionally substituted with R.sup.11);andR.sup.11 is H or C.sub.1-6 alkyl;and the salts, hydrates, and N-oxides.