Patent ID: 7374936
Filing Date: 2008-05-20
Classification: A61K

Abstract:
1. A method for killing target cells in a mammal by α-particle radiotherapy, wherein said target cells are in micrometastases having a diameter of about 1 mm or less, said method comprising providing a sufficient quantity of 225 Ac to produce a therapeutically effective amount of 213 Bi through radioactive decay, binding the 225 Ac onto a substrate for immobilizing 225 Ac, eluting from the substrate 213 Bi produced by bound 225 Ac, coupling the eluted 213 Bi, substantially free of 225 Ac, to a targeting moiety to form a conjugate, said targeting moiety being selected from the group consisting of a ligand having binding specificity for a receptor associated with said target cell or a ligand fragment having binding specificity for a receptor associated with said target cells, and administering said conjugate to said mammal to effectuate specific binding of said conjugate to said target cells.