Patent ID: 6166073
Filing Date: 2000-12-26
Classification: A61K,Y10S

Abstract:
A method of treating glaucoma or ocular hypertension in mammals which comprises administering to the mammal a pharmaceutically effective amount of the combination of:(a) a non-hyperemic amount of one or more DP-agonists of formula (III): ##STR7## wherein: R.sub.1 is H, alkyl or alkylcyloalkyl;R.sub.2 is alkyl, cycloalkyl or alkylcycloalkyl;L is carbon or oxygen; andG is ##STR8## wherein: R.sub.3 is H, OH or alkyl;R.sub.4 is H, F, Cl, I, or C.sub.1-3 alkyl;-- -- -- -- represents a single bond or double bond; provided that when a double bond is between the 13 and 14 position it is in the trans configuration;when L is carbon, G may also be ##STR9## and pharmaceutically acceptable salts thereof, and (b) a non-inflammatory amount of one or more FP-agonists of formula (IV): ##STR10## wherein: X is CH.sub.2 or O;Y is H and OH or O;M.sub.1 is H, C.sub.1-12 straight-chain or branched alkyl; C.sub.1-12 straight chain or branched acyl; C.sub.3-8 cycloalkyl; a cationic salt moiety; or an acceptable amine moiety;M.sub.2 and M.sub.3 are H or taken together are (.dbd.O); andM.sub.4 is C.sub.3-5 alkyl or ##STR11## Z is H, Cl or CF.sub.3 ; and provided that when M.sub.2 and M.sub.3 taken together are (.dbd.O), then M.sub.1 cannot be C.sub.1-12 straight chain or branched acyl; and when M.sub.2 and M.sub.3 are H, then M.sub.1 cannot be a salt or an amine; wherein the DP and FP-agonists are administered concomitantly or within 30 minutes of each other, and wherein the amounts of the DP and FP-agonists, separately, are not effective in treating glaucoma or ocular hypertension.