Patent ID: 8163909
Filing Date: 2012-04-24
Classification: A61P,C07D

Abstract:
1. A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein A A each of A R R R W is —C(═O)—, each R alternatively, two adjacent R R R R R X is CH Z is a 4-membered spirocyclic ring formed of carbon atoms optionally substituted independently with 1-5 substituents of R each R or R each R m is 0, 1, 2 or 3, provided the compound is not N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((2S,3R)-4-((S)-6-ethyl-2,2′-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-(4-phenyl -phenyl)-butan-2-yl)acetamide; (3S)—N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-1-cyclobutyl-5-oxo-3-pyrrolidinecarboxamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-ethyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)tetrahydro-2-furancarboxamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)propanamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(cyclopropylmethyl)oxy)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-ethyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide; N′-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4)-yl amino)-2-hydroxypropyl)-N,N-dimethylbutanediamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4S)-6-(4-morpholinyl)-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)-2-(methyloxy)acetamide; N-((1S,2R)-1-((3-cyano-5-fluorophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl) amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4S)-6-(4-morpholinyl)-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide; 2-(((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4S)-6-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)amino)-2-oxoethyl dimethylcarbamate; N-((1S,2R)-3-(((4S)-8-bromo-6-chloro-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide; N-((1S,2R)-3-(((4S)-6-chloro-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((5′S)-3′-methyl-5′,8′-dihydro-6′H-spiro[cyclobutane-1,7′-quinolin]-5′-yl)amino)propyl)acetamide; N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(trifluoromethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide; N-((1˜-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)—N˜2˜,N˜2˜-dimethylglycinamide; Methyl(4S)-4-(((2R,3S)-4-(3-cyanophenyl)-3-((N,N-dimethylglycyl)amino)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate; Methyl(4S)-4-(((2R,3S)-3-(acetylamino)-4-(3-cyanophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate; Methyl(4S)-4-(((2R,3S)-4-(3-cyanophenyl)-2-hydroxy-3-(((methyloxy)acetyl)amino)butyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate; N-((1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; N-((1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide; and N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide.