Patent ID: 6380203
Filing Date: 2002-04-30
Classification: C07D

Abstract:
A compound in accordance with formula I: or a pharmaceutically acceptable salt, hydrate or prodrug thereof,whereinR1 is aryl, optionally substituted with one to three substituents selected from Ra; R2 and R3 are independently H, C1-6 alkyl, aryl, C3-6 cycloalkyl, OH, NO2, NH2, or halogen; R4 is aryl or heteroaryl, substituted with one to three substituents selected from Ra; R5 is H, or C1-6 alkyl, OR, halo, NH2 or NO2; Ra is C1-10 alkyl, halogen, NO2, OR, OC1-6 alkyl-NR7R8, NR7R8, aryl, or heterocyclyl; R is H or C1-6 alkyl; and R7 and R8 are independently selected from: H, C1-10 alkyl, C3-6 cycloalkyl, COR, COOR, aryl, and heterocyclyl, or NR7R8 can be taken together to form a heterocyclic 5-10 membered saturated or unsaturated ring optionally containing, in addition to the nitrogen atom, one to two additional heteroatoms selected from N, O and S.