Patent ID: 6498156
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A compound of the formula I, or a pharmaceutically acceptable salt or ester thereof, in whichR1, R2, R3, R4, R5, R6 independently of one another are (C0-C30)-alkylene-L, where one or more carbon atoms of the alkylene radical may be replaced by â€”Oâ€”, â€”(C&boxH;O)â€”, â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”N((C1-C6)-alkyl)- or â€”NHâ€”; or H, F, Cl, Br, I, CF3, NO2, CN, COOH, COO(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON[(C1-C6)-alkyl]2, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl or Oâ€”(C1-C6)-alkyl, where one or more hydrogens in the alkylene radicals may be replaced by fluorine; or SO2â€”NH2, SO2NH(C1-C6)-alkyl, SO2N[(C1-C6)-alkyl]2, Sâ€”(C1-C6)-alkyl, Sâ€”(CH2)n-phenyl, SOâ€”(C1-C6)-alkyl, SOâ€”(CH2)n-phenyl, SO2â€”(1-C6)-alkyl or SO2â€”(CH2)n-phenyl, where n=0-6 and the phenyl radical may be substituted up to two times by F, Cl, Br, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, (C1-C6)-alkyl or NH2; or NH2, NHâ€”(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH(C1-C7)-acyl, phenyl or Oâ€”(CH2)n-phenyl, where n=0-6, where the phenyl ring may be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, (C1-C6)-alkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, SO2â€”CH3, COOH, COOâ€”(C1-C6)-alkyl or CONH2; is shown connected to (C0-C30)-alkylene as follows: R7 is methyl, ethyl, propyl or butyl; R8 is H, OH, NH2 or NHâ€”(C1-C6)-alkyl; R9 is methyl, ethyl, propyl or butyl; R10 is methyl, ethyl, propyl or butyl; wherein at least one of the radicals R1 to R6 has the meaning (C0-C30)-alkylene-L, where one or more carbon atoms of the alkylene radical may be replaced by â€”Oâ€”, â€”(C&boxH;O)â€”, â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”N((C1-C6)-alkyl)- or â€”NHâ€”.