Patent ID: 6630128
Filing Date: 2003-10-07
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I, whereinR1, R2, R3, R4, R5, R6, R7, R8, and R9 independently represent H, lower alkyl, lower alkenyl and lower alkynyl, tile latter three of which are optionally substituted or terminated by one or more substituents selected from halo, cyano, nitro, lower alkyl, OR10, C(O)R11, C(O)OR12, C(O)NR13R14 and NR15R16; M represents a metallic element or a metalloid element; X represents SH, Sâ€”]2, OH, NHR15, CO2H, Cl, Br, I, NCO, NCS, CN, CCâ‰¡H, CH&boxH;CH2, MgCl, ZnCl, Li, Si(OR17)3, SiR18(OR17)2, SiR18R19(OR17), Sihalo3, Sihalo2R17, SihaloR17R18, silyl, NO2, CHO C(O)]2O, C(O)halo, C(O)OR20, OC(O)halo, C(O)N3, thiocyano, or halobenzyl; Each Y1, Y2, Y3 is independently absent or represents O; Z is absent or represents lower alkylene; R10, R11, R12, R13, R14, and R16 independently represent H or lower alkyl; R15 represents H, lower alkyl, aryl or lower alkylaryl; R17, R18 and R19 independently represent H, lower alkyl, aryl or lower alkylaryl; R20 represents H, lower alkyl, lower alkenyl or C(O)R21 where R21 represents an activating group for reaction to form an arnide bond such as N-hydroxysucciniride, N-hydroxybenzotriazole, or pentafluorophenyl ester; and A-B and C-D independently represent CH&boxH;CH or CH2â€”CH2, provided that when A-B and C-D both represent CH&boxH;CH then each Y1, Y2 and Y3 represents oxygen, or each Y1 and Y3 represents oxygen and each Y2 is absent.