Patent ID: 8853234
Filing Date: 2014-10-07
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof; wherein each of B, X, A or V is absent if Z each of B, X, A and V is independently H, halo, azido, —CN, —CF Z is O, S, CR each of Z Z Y is an optionally substituted 5-6 membered carbocyclic or heterocyclic ring; U U in each —NR R R R each R each R and R L is a C1-C10 alkylene, C1-C10 heteroalkylene, C2-C10 alkenylene or C2-C10 heteroalkenylene linker, each of which may be optionally substituted with one or more substituents selected from the group consisting of halogen, oxo (═O), or C1-C6 alkyl; W is an optionally substituted 4-7 membered azacyclic ring, optionally containing an additional heteroatom selected from N, O and S as a ring member; W provided one of V, A, X and B is a secondary amine A the secondary amine A the tertiary amine A with the proviso that when Z