Patent ID: 7514066
Filing Date: 2009-04-07
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of tumor therapy in a patient, comprising: (A) administering a therapeutic naked antibody or a first conjugate comprising a multispecific antibody or antigen-binding fragment thereof and a first therapeutic agent, wherein the multispecific antibody selectively binds to (i) a marker substance produced by the tumor and (ii) to a hapten or to a second therapeutic agent; (B) optionally, administering a clearing agent; and (C) administering a second therapeutic agent or a second conjugate comprising a hapten to which said first conjugate binds and a second therapeutic agent, wherein the second therapeutic agent is the same as or different from the first therapeutic agent and wherein the first and second therapeutic agents are selected from the group consisting of radionuclides, cytokines, drugs, toxins, antibodies and oligonucleotides.