Patent ID: 6121423
Filing Date: 2000-09-19
Classification: C07K

Abstract:
An isolated polypeptide light (L) chain of an antibody to human interleukin-6, wherein the L chain comprises an L chain variable (V) region and a human L chain constant (C) region; wherein the L chain V region is represented by the formula (I):FRL1-CDRL1-FRL2-CDRL2-FRL3-CDRL3-FRL4wherein the FRL1, FRL2, FRL3 and FRL4 have the following amino acid sequences respectively:FRL1: Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys (SEQ ID NO: 69);FRL2: Trp Tyr Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr (SEQ ID NO: 70);FRL3: Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys (SEQ ID NO: 71);andFRL4: Phe Gly Gln Gly Thr Lys Val Glu Ile Lys (SEQ ID NO: 72);and the CDRL1, CDRL2 and CDRL3 have the following amino acid sequences respectively;CDRL1: Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala (SEQ ID NO: 62)CDRL2: Ala Ala Thr Tyr Leu Ala Asp (SEQ ID NO: 63)CDRL3: Gln His Phe Trp Gly Thr Pro Pro (SEQ ID NO: 64)orwherein the L chain V region comprises a polypeptide encoded by the nucleotide sequence shown in SEQ ID NO: 56.