Patent ID: 8980272
Filing Date: 2015-03-17
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A purified monoclonal antibody capable of binding to at least one human or murine dendritic cell specific transmembrane protein (DC-STAMP) selected from the group consisting of: a protein comprising the amino acid sequence of SEQ ID NO: 2, and a protein comprising the amino acid sequence of SEQ ID NO: 4, and suppressing formation of osteoclasts derived from murine bone marrow cells or suppressing formation of osteoclasts derived from human peripheral blood mononuclear cells, wherein the monoclonal antibody binds in the region of amino acid residues 330-343 of SEQ ID NO: 2 or in the region of amino acid residues 330-343 of SEQ ID NO: 4.