Patent ID: 8951972
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating cancer in a subject comprising administering to the subject an effective amount of a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) fusion molecule and at least one additional therapeutic agent selected from docetaxel, vincristine, and topotecan, wherein the FGFR1 ECD fusion molecule comprises an FGFR1 ECD comprising an amino acid sequence selected from SEQ ID NOs: 1 to 4 and a fusion partner, and wherein administration of the FGFR1 ECD fusion molecule and the at least one additional therapeutic agent results in synergistic inhibition of tumor growth in a mouse xenograft model of the cancer, wherein the cancer is small cell lung cancer and the mouse xenograft model comprises DMS 53 cells.