Patent ID: 8026273
Filing Date: 2011-09-27
Classification: A61P,C07D

Abstract:
1. An 8-azaprostaglandin derivative compound represented by formula (I): wherein T is (1) an oxygen atom; X is (1) —CH A is A A G G Y is (1) —S—, (2) —SO—, or (3) —SO G D is D D R E is E E R W R W E U U U R ring1, ring2, ring3 or ring4 may be substituted by 1 to 5R; R is (1) C1-10 alkyl, (2) C2-10 alkenyl, (3) C2-10 alkynyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) halogen, (7) hydroxy, (8) nitro, (9) —NR R ring5 may be substituted by 1 to 3 substituent(s) selected from following (1)-(9): (1) C1-10 alkyl, (2) C2-10 alkenyl, (3) C2-10 alkynyl, (4) C1-10 alkoxy, (5) C1-10 alkyl substituted by C1-10 alkoxy, (6) halogen atom, (7) hydroxy, (8) C1-10 alkyl substituted by 1 to 3 halogen atom(s), (9) C1-10 alkyl substituted by C1-10 alkoxy substituted by 1 to 3 halogen atom(s); ring1, ring2, ring3, ring4 and ring5 are, each independently, (1) C3-15 mono-, bi- or tri-carbocyclic aryl which may be partially or fully saturated or (2) 3- to 15-membered mono-, bi- or tri-heterocyclic aryl which may be partially or fully saturated and contains a hetero atom(s) selected from 1 to 4 nitrogen, 1 to 2 oxygen and/or 1 to 2 sulfur atom(s); and wherein 1) when E is E 2) when U a pharmaceutically acceptable salt thereof.