Patent ID: 6255348
Filing Date: 2001-07-03
Classification: A61K,A61P

Abstract:
A method for the treatment of AIDS by increasing the activity of already activated neutrophils which comprises contacting the neutrophils with an aminoadamantane compound of formula (I) ##STR3##wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are selected independently from each other from --NR.sub.5 R.sub.6, --NR.sub.5 R.sub.6 R.sub.7.sup.+, hydrogen, aryl or heteroaryl with up to 7 ring members, C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -alkenyl and C.sub.1 -C.sub.20 -alkynyl, wherein the alkyl, alkenyl and alkynyl groups can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members with the proviso that at least one of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are represented by --NR.sub.5 R.sub.6 or --NR.sub.5 R.sub.6 R.sub.7.sup.+ ; and R.sub.5, R.sub.6 and R.sub.7 are selected independently from each other from hydrogen, aryl or heteroaryl with up to 7 ring members, C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -alkenyl, C.sub.1 -C.sub.20 -alkynyl, wherein the alkyl, alkenyl and alkynyl groups can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members, or R.sub.5 and R.sub.6, together with the nitrogen atom, form a heterocyclic group with up to 7 ring members in a concentration of said aminoadamantane compound of from 10.sup.-6 to 10.sup.-5 M.