Patent ID: 6222034
Filing Date: 2001-04-24
Classification: A61P,C07D

Abstract:
A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine compound of formula I ##STR9##whereinR.sup.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, acetyl or benzoyl, a phenylalkyl C.sub.1 -C.sub.4 radical, wherein the aromatic ring is unsubstituted or substituted by halogen, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, cyano or nitro groups,a naphthylalkyl C.sub.1 -C.sub.3 radical, a phenylalkanone C.sub.2 -C.sub.3 -radical or a phenylcarbamoylalkyl C.sub.2 radical, wherein the phenyl ring is unsubstituted or substituted by halogen,R.sup.2 is phenyl, pyridyl, pyrimidyl or pyrazinyl, each of which is unsubstituted or carries substituents selected from the group consisting of:(i) one to three of the following: halogen, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano and nitro, and(ii) one phenyl-C.sub.1 -C.sub.2 -alkyl or phenyl-C.sub.1 -C.sub.2 -alkoxy, wherein the phenyl ring is unsubstituted or substituted by halogen, methyl, trilfuoromethyl or methoxy, oris one of the foregoing unsubstituted or substituted phenyl, pyridyl, pyrimidyl or pyrazinyl radicals wherein two adjacent ring carbon atoms are bridged to form a benzo-fused or a pyridino-fused bicyclus wherein the bridging moiety is unsubstituted or substituted by one or two substituents selected from the group consisting of: halogen, C.sub.1 -C.sub.4 -alkyl, hydroxyl, trifluoromethyl, C.sub.1 -C.sub.4 -alkoxy, amino, cyano and nitro, oris one of the foregoing unsubstituted or substituted phenyl, pyridyl, pyrimidyl or pyrazinyl radicals wherein two adjacent ring carbon atoms are bridged to form a 5- or 6-membered ring consisting of carbon ring members or carbon ring members and one or two oxygen atoms as ring members,A is NH or an oxygen atom,B is hydrogen or methyl,C is hydrogen, methyl or hydroxyl,X is a nitrogen atom,Y is CH.sub.2, CH.sub.2 --C.sub.2, CH.sub.2 --C.sub.2 --CH.sub.2 or CH.sub.2 --CH,Z is a nitrogen atom, carbon atom or CH, wherein the linkage between Y and Z is a single or a double bond, andn is 2, 3 or 4,or a physiologically tolerated salt thereof.