Patent ID: 8858997
Filing Date: 2014-10-14
Classification: A61K,A61P,Y10S

Abstract:
1. A method for lyophilizing glibenclamide to provide a lyophilized solid glibenclamide composition having less than about 1% w/w buffer, comprising: a) preparing an aqueous solution of said glibenclamide in the absence of buffer, b) adding to the solution one or more substantially pharmaceutically inert compounds as a bulking agent, c) adjusting the pH of the solution to greater than about pH 8 effective to increase the solubility of the glibenclamide, d) adding additional glibenclamide to the solution, and e) freeze-drying the solution to provide a lyophilized solid composition that comprises glibenclamide and less than about 1% w/w buffer, and a weight of substantially pharmaceutically inert compounds that comprises at least about 10 times the weight of glibenclamide in the lyophilized solid glibenclamide composition.