Patent ID: 9132171
Filing Date: 2015-09-15
Classification: A61K,A61L

Abstract:
1. A method of preventing restenosis, the method comprising: contacting to an external surface of a blood vessel having an intravascular wound a gel or semi-solid composition comprising connective tissue growth factor (CTGF) and insulin in therapeutically effective amounts to prevent restenosis, wherein the composition suppresses neo-intimal growth and increases adaptive remodeling in the vessel relative to a blood vessel having an intravascular wound that is not contacted to the composition whereby restenosis is prevented, and wherein an effective amount of insulin is about 0.3 μg/mL to about 5 μg/mL, and an effective amount of CTGF is about 0.1 μg/mL to about 0.5 μg/mL.