Patent ID: 6911447
Filing Date: 2005-06-28
Classification: A61P,C07D,C07K

Abstract:
1. A compound, or all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, said compound having the formula: wherein A is a conformationally restricted ring system selected from the group consisting of: wherein the carbon atoms marked with an asterisk can have any stereo-chemical configuration W has the formula: R is phenyl or substituted phenyl; wherein R a) rings consisting of: b) hydrogen; c) a unit selected from the group consisting of —CH d) two of R c) mixtures thereof; Y is a pendant unit containing at least one heteroatom having the formula: wherein R Z is a pendant unit, which contains an aromatic carbocyclic ring; said unit having the formula: wherein R 8 is hydrogen; R 9 is phenyl, benzyl, 1-naphthyl, 2-naphthyl, 1 -naphthylmethyl, 2-naphthylmethyl; R 10 is hydrogen, —C(X) 2 R 17 , —C(X)N(R 16 ) 2 , —N(R 16 ) 2 —N − (R 16 ) 3 D − , —C(X)N 1 (R 16 ) 3 D, and —NR 16 C(X)R 17 ; R 16 is hydrogen, or C 1 -C 10 alkyl, R 17 is C 2 -C 16 linear or branched, substituted or unsubstituted alkyl, C 1 -C 16 linear or branched, substitutod or unsubstituted alkylenearyl; X is oxygen, sulfur, and —NR 16 , D is a salt forming anion.