Patent ID: 6090782
Filing Date: 2000-07-18
Classification: A61K,A61P,C07K,H04M

Abstract:
A method of inhibiting stem cell proliferation comprising contacting hematopoietic cells with a stem cell proliferation inhibiting amount of a composition comprising at least one peptide selected from the group consisting of the peptides having the sequence:Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val (SEQ ID NO:1),Cys-Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Cys (SEQ ID NO:2)(wherein the two Cys residues form a disulfide bond),Asp-Ala-Leu-Thr-Asn-Ala-Val-Ala-His-Val-Asp-Asp-Met-Pro-Asn-Ala-Leu-Ser-Ala (SEQ ID NO:3),Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe (SEQ ID NO:4),Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg (SEQ ID NO:5),Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln (SEQ ID NO:6),Leu-Val-Val-Tyr-Pro-Trp-Thr (SEQ ID NO:7),Leu-Val-Val-Tyr-Pro-Trp (SEQ ID NO:8),Leu-Val-Val-Tyr-Pro (SEQ ID NO:9),Val-Val-Tyr-Pro-Trp-Thr-Gln (SEQ ID NO:10),Tyr-Pro-Trp-Thr-Gln-Arg-Phe (SEQ ID NO:ll),Tyr-Pro-Trp-Thr-Gln-Arg (SEQ ID NO:12),Tyr-Pro-Trp-Thr-Gln (SEQ ID NO:13), andTyr-Pro-Trp-Thr.