Patent ID: 6765109
Filing Date: 2004-07-20
Classification: C07C

Abstract:
A method for enantioselectively preparing S-aryl-L-cysteine of the formula: comprising contacting a compound of the formula: with an aryl thiol in the presence of a base in a non-polar reaction solvent to produce said S-aryl-L-cysteine;wherein Ar is a substituted or unsubstituted aryl group selected from the group consisting of phenyl, naphthyl, pyridyl, furyl, thiophenyl, pyrazyl, and pyrrolyl; P1 is an amine protecting group; P2 is a carboxylic acid protecting group; and X is a halide, mesylate or tosylate; and wherein said method produces said S-aryl cysteine in enantiomeric excess of greater than about 96%.