Patent ID: 7806924
Filing Date: 2010-10-05
Classification: A61L,A61P

Abstract:
1. A medical device comprising: an implantable structure; a basecoat matrix, including a combination of rapamycin and cladribine, in therapeutic dosages, incorporated in a first polymeric material comprising polyvinylidenefluoride-co-hexafluoropropylene with a weight ratio of 60 weight percent vinylidenefluoride to 40 weight percent hexafluoropropylene, the basecoat matrix being affixed to the surface of the implantable medical device, the concentration of cladribine being in the range from about fifty-six nano molar to about nine-hundred nano molar; and a topcoat, including a second polymeric material comprising poly(n-butylmethacrylate), affixed to the basecoat matrix for controlling the elution rate of the combination of rapamycin and cladribine, wherein the second polymeric material is incompatible with the first polymeric material, thereby creating both a physical and chemical barrier to the elution of the rapamycin and cladribine.