Patent ID: 7351706
Filing Date: 2008-04-01
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein A is selected from the following groups (a), (b), (c), (d), (e) and (f): each X is the same or different and is CR iii R iv , NR iii or O, wherein in (a), only one X can be O, the other being CR iii R iv or NR iii ; R 1 is H, C aryl, 5 or 6 membered heteroaryl or sulfonylaryl each of which is optionally substituted by one or more B, —(CH or —(CH or R 1 and R 3 together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by (CO); there can be one or more R 2 wherein each R 2 is H, OH, halo, CN, nitro, C 1-6 -alkyl optionally substituted by —NR iii R iv , C 1-6 -alkoxy, —O—CH 2 —C 2-6 -alkenyl, benzyloxy, or C 1-6 -haloalkyl, or two R 2 together with the indole ring to which they are attached form an oxo or dioxo bridge; R 3 is H, halo, —(CO)—R or C there can be one or more R 4 wherein each R 4 is H, halo, C 1-6 alkyl, C 1-6 alkoxy, or CN, or two R 4 together with the phenyl ring to which they are attached form an oxo or dioxo bridge; B is halo, CN, C C C C —C(O)O—C —C(O) NR —C(O)—C —S(O) —S(O) (CR R i and R ii are each independently H, C 1-6 -alkyl, C 1-6 -alkylene-NR iii R iv , —(CO)O—C 1-6 -alkyl, —C(O)—NR iii R iv , —C(O)—C 1-6 -alkyl, —S(O) 2 —C 1-6 -alkyl or —S(O) 2 —NR iii R iv ; R iii is H, C 1-6 -alkyl or C 1-6 -alkylene-N(R iv ) 2 ; R iv is H or C 1-6 -alkyl; m is 1 to 6; and n is 0 to 4; or a pharmaceutically acceptable salt thereof.