Patent ID: 6348203
Filing Date: 2002-02-19
Classification: A61K,A61P,Y10S

Abstract:
A method of preparing a viscous hydrogel composition, for use in a topical treatment of a skin condition involving dry or inflamed skin, including a pharmaceutically active agent, a polysaccharide, a water-miscible organic solvent and water, comprising the steps of suspending the polysaccharide in the water-miscible organic solvent and mixing the resulting polysaccharide suspension into an aqueous medium, wherein the pharmaceutically active agent is present in the aqueous medium, the suspension, or both, thereby to hydrate the polysaccharide and to form a viscous hydrogel composition, wherein the pharmaceutically active agent is an antimicrobially active nitroimidazol drug, the water-miscible organic solvent is a water-miscible alkylene glycol, and the composition is buffered with an ionic buffer to have a pH within the range of 4.5-6.5.