Patent ID: 6248747
Filing Date: 2001-06-19
Classification: A61P,C07D

Abstract:
A method of treating a subject suffering from benign prostatic hyperplasia which comprises administering to the subject an amount of a compound effective to treat benign prostatic hyperplasia, wherein the compound has the structure: ##STR23##wherein A is ##STR24##wherein each of Y.sub.1, Y.sub.2 and Y.sub.3 is independently H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl; --F, --Cl, --Br, --I, --NO.sub.2, --N.sub.3, --CN, --OR.sub.6, --OCOR.sub.6, --COR.sub.6, --CONHR.sub.6, --CON(R.sub.6).sub.2, --COOR.sub.6, --CF.sub.3 or together constitute a methylenedioxy group;wherein X is S, O or NH;wherein R.sub.1 is H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl; --NHR.sub.6, --N(R.sub.6).sub.2 or --OR.sub.6 ;wherein R.sub.2 is H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl; C.sub.3 -C.sub.10 cycloalkyl-C.sub.1 -C.sub.10 -alkyl, cycloalkyl-C.sub.1 -C.sub.10 -monofluoroalkyl or cycloalkyl-C.sub.1 -C.sub.10 -polyfluoroalkyl; --CN, --CH.sub.2 XR.sub.6, --CH.sub.2 X(CH.sub.2).sub.n NHR.sub.6, --(CH.sub.2).sub.n NHR.sub.6, --CH.sub.2 X(CH.sub.2).sub.n N(R.sub.6).sub.2, --CH.sub.2 X(CH.sub.2).sub.n N.sub.3 or CH.sub.2 X(CH.sub.2).sub.n NHCXR.sub.7 ;wherein n is an integer from 0 to 5 and wherein X is as defined above;wherein R.sub.3 is H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl;wherein R.sub.4 is ##STR25##wherein each R is independently H; F; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl;wherein R.sub.5 is H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl; phenyl, thiophenyl, pyridyl, pyrrolyl, furanyl, imidazolyl or indolyl; --COOR.sub.6, --COR.sub.6, --CONHR.sub.6, --CN, --OH or --OR.sub.6 ;wherein each m is independently an integer from 0 to 3; wherein o is an integer from 1 to 3; wherein each n is independently an integer from 0 to 5;wherein each R.sub.6 is independently H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl;wherein R.sub.7 is phenyl, pyridyl, thiophenyl, furanyl, pyrazinyl, pyrrolyl, naphthyl, indolyl, imidazolyl, benzfurazanyl, benzfuranyl or benzimidazolyl; C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl or alkynyl wherein the alkyl, monofluoroalkyl, polyfluoroalkyl, alkenyl or alkynyl is substituted with phenyl, pyridyl, thiophenyl, furanyl, pyrazinyl, pyrrolyl, naphthyl, indolyl, imidazolyl, benzfurazanyl, benzfuranyl or benzimidazolyl;wherein each of Y.sub.1, Y.sub.2 and Y.sub.3 is as defined above; wherein X is as defined above;wherein Z is C.sub.2 alkenyl or alkynyl, CH.sub.2, O, CO, CO.sub.2, CONR.sub.6, S, SO, SO.sub.2 or NR.sub.6 ; andwherein each D is independently CH.sub.2, O, S, NR.sub.6, CO or CS; or a pharmaceutically acceptable salt thereof.