Patent ID: 9119791
Filing Date: 2015-09-01
Classification: A61K,A61P

Abstract:
1. A method of treating seizures comprising administering to a subject in need thereof pharmaceutical formulation for once-a-day administration of oxcarbazepine comprising a homogeneous matrix comprising: (a) oxcarbazepine; (b) 1-50%, by weight of the formulation, a matrix-forming polymer; (c) 1-80%, by weight of the formulation, at least one agent that enhances the solubility of oxcarbazepine; and (d) 10-90%, by weight of the formulation, at least one release promoting agent comprising a polymer having pH-dependent solubility selected from the group consisting of cellulose acetate phthalate, cellulose acetate succinate, methylcellulose phthalate, ethylhydroxycellulose phthalate, polyvinylacetate phthalate, polyvinylbutyrate acetate, vinyl acetate-maleic anhydride copolymer, styrene-maleic mono-ester copolymer, Eudragit L100-55 (Methacrylic Acid-Ethyl Acrylate Copolymer (1:1)), and methyl acrylate-methacrylic acid copolymers.