Patent ID: 7021163
Filing Date: 2006-04-04
Classification: G01N

Abstract:
1. Apparatus for monitoring the dissolution properties of a solid dosage form containing at least one active ingredient, said apparatus comprising a dissolution chamber, video monitoring means, and dissolution liquid analyzing means, said dissolution chamber comprising a hollow vessel having an interior in which a dosage form support is located and an inlet and outlet coupled to the interior of said chamber, said dosage form support being arranged to support the dosage form within a predetermined visualization field in said chamber, said inlet of said chamber being adapted to enable a dissolution liquid to flow gently through the interior of said chamber for exposure to the dosage form, said support and said gentle flow of the dissolution liquid tending to prevent displacement of said dosage form from said visualization field, said flow of dissolution liquid causing the dosage form to dissolve in the dissolution liquid, said outlet of said chamber being coupled to said analyzing means for carrying the dissolution liquid to said analyzing means for analyzing the properties of the dissolution liquid, said video monitoring means being adapted for aiming at said visualization field to provide a series of high quality images of the dosage form simultaneously with the analysis of the dissolution liquid by said analyzing means, said apparatus further comprising a baffle arranged for diverting the flow of the dissolution liquid entering into said chamber so that the entering dissolution liquid does not directly impact the dosage form in said visualization field, thereby providing said gentle flow and not interfering with the imaging of the dosage forms during the flow of said dissolution liquid.