Patent ID: 7977346
Filing Date: 2011-07-12
Classification: A61P,C07D

Abstract:
1. A spiro compound of formula I Wherein a is 1, 2, 3, 4 or 5; b and c are each independently 1, 2, or 3; When X and Y are selected from (i) X combines Y to be an oxygen or methylene, (ii) X is hydrogen, Y is hydrogen, (iii) X is hydrogen, Y is hydroxy or its optical isomer; R′ and R″ are not presented; When X and Y are selected from (iv) X is hydrogen, Y is O, S or its optical isomer position, (v) X and Y are both O or S, or (vi) X is O and Y is S; R′ and R″ are each independently halogeno-lower alkyl, lower alkyl, lower alkoxy, hydroxy, lower alkylhydroxy; optionally R′ and R″ combine to form a 5 to 7 membered ring with X, Y and the spiro carbon which ring, may be unsubstituted or substituted independently by up to three substituents; R is selected from: and G is N R W is selected from O, S, —NR Z is selected from O, S, —NR R R R R Or a pharmaceutically acceptable salt thereof.