Patent ID: 8945579
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A method of stimulating an immune response in a subject, comprising the step of administering to the subject a composition that includes at least one fusion protein comprising at least a portion of at least one flagellin that initiates an intracellular signal transduction pathway for a Toll-like Receptor and a portion of a protein of a naturally occurring influenza viral hemagglutinin, wherein the portion lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit and includes at least a portion of a globular head and at least a portion of at least one secondary structure having at least one β-sheet at a bottom of the portion of the globular head that causes the portion of the globular head to essentially retain its tertiary structure.