Patent ID: 6020139
Filing Date: 2000-02-01
Classification: A61K

Abstract:
A method to identify a therapeutic composition or protocol which ameliorates a disease or undesired condition in a subject, which method relies upon recognition of the existence of, and the interconnections between, eight SAM pathways shown in FIGS. 9, herein, which method comprises:(a) determining the presence of said disease or condition in said subject;(b) identifying any abnormalities in each of said eight SAM pathways and optionaily in the interconnections therebetween by determining(i) concentrations of metabolites, and/or(ii) concentrations or activities of enzymes, and/or(iii) levels of cellular functions,that are participants in, or are results of, SAM pathways thereby obtaining a data set of the differences of said concentrations, activities, and/or levels from corresponding normal concentrations, activities, and/or levels,(c) analyzing said data set by ascertaining, for each difference in concentration, activity, and/or level the position or function of the corresponding metabolite, enzyme or cellular function in said eight SAM pathways or the interconnections therebetween, so as to determine which of one or more metabolites and/or enzymes and/or cellular functions of said SAM pathways is a causative agent of said differences in concentrations, activities or levels in said data set; and(d) identifying a therapeutic composition or protocol which acts to restore said pathways toward normality, so as to ameliorate said disease or condition,thereby identifying a composition or protocol that ameliorates said disease or condition.