Patent ID: 8871219
Filing Date: 2014-10-28
Classification: A61K,C07K,C12N

Abstract:
1. A recombinant modified Vaccinia Ankara (MVA) vector comprising nucleotide sequences encoding a modified human immunodeficiency type 1 virus (HIV-1) Env protein and a HIV-1 Gag-Pol-Nef fusion protein, wherein the nucleotide sequence encoding the modified HIV-1 Env protein is SEQ ID NO:15 or SEQ ID NO:17, wherein the nucleotide sequence encoding the Env protein and the nucleotide sequence encoding the Gag-Pol-Nef fusion protein are under the control of identical promoters and are both inserted at the thymidine kinase locus of the vector so that the recombinant vector lacks the thymidine kinase gene.