Patent ID: 6300352
Filing Date: 2001-10-09
Classification: A61P,C07D,C07F

Abstract:
A compound of formula I: ##STR117##wherein:X is O or S;R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-6 alkyl or C.sub.3-6 cycloalkyl or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkyl group;R.sup.3 is hydrogen, and R.sup.4 is C.sub.1-6 alkyl or C.sub.3-6 cycloalkyl or R.sup.3 and R.sup.4 together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkyl group;Ar.sup.1 is indanyl, tetrahydronaphthyl, naphthyl, phenyl, C.sub.7-9 alkylphenyl or biphenyl, which latter four groups can be optionally substituted by one or more groups selected from halo, nitro, cyano, pyridyl, thiazinyl, C.sub.1-10 alkyl (optionally substituted by one or more fluorine is atoms), --Y--OR.sup.5, --Y--NR.sup.6 C(O)NR.sup.7 --R.sup.8,--O--Z--C(O)NR.sup.7 R.sup.8, --O--Y--C(S)NR.sup.7 R.sup.8, --Y--C(O)NR.sup.7 R.sup.8, --Y--SO.sub.2 NR.sup.7 R.sup.8, --Y--NR.sup.7 R.sup.8, --Y--OC(O)NR.sup.7 R.sup.8, --Y--C(S)NR.sup.7 R.sup.8, --Y--C(O)R.sup.9, --Y--OC(O)R.sup.9, --Y--CO.sub.2 R.sup.9, --Y--NR.sup.10 C(O)NR.sup.11 --Z--R.sup.12, SO.sub.2 NR.sup.10 C(O)NR.sup.7 R.sup.8, --Y--SO.sub.2 NHNR.sup.7 R.sup.8, --Y--C(O)NR.sup.11 --Z--R.sup.12, --Y--C(S)NR.sup.11 --Z--R.sup.12, --Y--N(R.sup.10)SO.sub.2 R.sup.11, --Y--N(R.sup.10)C(O)R.sup.11 or --Y--N(R.sup.10)CO.sub.2 R.sup.11 ; where:Y is a bond, C.sub.1-6 alkylene or C.sub.2-6 alkenylene;R.sup.7 and R.sup.8 are independently hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form an optionally substituted 5- to 7-membered heterocyclic ring optionally containing a further heteroatom selected from nitrogen, oxygen or sulfur; R.sup.5, R.sup.6, R.sup.9, R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-0 alkyl (optionally substituted by one or more fluorine atoms);Z is C.sub.1-6 alkylene; andR.sup.12 is a group NR.sup.10 C(O)R.sup.11, NR.sup.10 CO.sub.2 R.sup.11, OR.sup.5, NR.sup.7 R.sup.8 or CO.sub.2 R.sup.13 where R.sup.5, R.sup.7, R.sup.8, R.sup.10 and R.sup.11 are as defined above and R.sup.13 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkylaryl or aryl optionally substituted by hydroxy,or a salt or solvate thereof.