Patent ID: 6555321
Filing Date: 2003-04-29
Classification: A61K,C07K

Abstract:
A method for screening an EphB receptor-binding ligand for the ability to promote a selected biological activity when in multimeric form, comprising:a) contacting a multimeric EphB receptor-binding ligand with an EphB receptor-expressing cell under conditions whereby the ligand can bind the receptor; and b) detecting the selected biological activity in cells which have bound multimeric ligand as compared to the selected biological activity in cells which have not bound multimeric ligand, whereby a higher level of the selected biological activity in cells which have bound multimeric ligand compared to level of the selected biological activity of cells which have not bound multimeric ligand identifies an EphB receptor-binding ligand with the ability to promote the selected biological activity when in multimeric form.