Patent ID: 6210904
Filing Date: 2001-04-03
Classification: A61K,C07K,G01N

Abstract:
A method for diagnosing a patient at risk to thrombocytopenia induced by administration of a glycoprotein IIb/IIIa receptor antagonist, by detecting the absence of association of a detectable monoclonal antibody with a glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex, which comprises combiningi) a plasma sample of the patient;ii) the detectable monoclonal antibody, which is mAb10-758 or mAb15-758, which recognizes induced binding sites formed on the glycoprotein IIb/IIIa receptor following association of a glycoprotein IIb/IIIa receptor antagonist with the glycoprotein IIb/IIIa receptor; andiii) the glycoprotein IIB/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex,and detecting the absence of association of the detectable monoclonal antibody with the complex in the presence of the plasma.