Patent ID: 6239131
Filing Date: 2001-05-29
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (I) or a salt thereof: ##STR523##whereinR.sub.1 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, or a halogen atom;each of R.sub.2 and R.sub.3, which may be the same or different, represents a hydrogen atom, a lower alkenyl group, a lower alkyl group which may be substituted by a halogen atom, a lower alkylsulfonyl group, a mono- or di-lower alkoxyalkyl group, a phenyl group which may have a substituent, a group represented by --CH(R.sub.6)R.sub.7 (wherein R.sub.6 represents a lower alkyl group, a lower alkoxyl group, a mono- or di-lower alkoxyalkyl group, a saturated or unsaturated hydrocarbon group having a bicyclic or tricyclic C7-C10 condensed ring, or a phenyl or heterocyclic group which may have a substituent; and R.sub.7 represents a hydrogen atom or a lower alkyl group), or a group represented by --CO--R.sub.8 (wherein R.sub.8 represents a lower alkyl group which may be substituted by a halogen atom; a lower alkenyl group; a lower alkoxyl group; a mono- or di-lower alkoxyalkyl group; an adamantyl group; a hydroxyl group; a benzyloxy group; a phenyl or heterocyclic group which may have a substituent; or a group represented by --N(R.sub.9)R.sub.10 (wherein R.sub.9 and R.sub.10 may be the same or different, and each represents a hydrogen atom, a lower alkyl group, a hydroxyalkyl group, a mono- or di-lower alkylaminoalkyl group, a phenyl group, or a heterocyclic group which may have a substituent));each of R.sub.4 and R.sub.5, which may be identical to or different from each other, represents a hydrogen atom, a lower alkyl group which may be substituted by a halogen atom, a lower alkoxyl group, a halogen atom, a hydroxyalkyl group, an amino group, a nitro group, a mono- or di-lower alkylamino group, a lower alkylsulfonylaminocarbonyl group, a hydroxyaminocarbonyl group, a benzyloxyaminocarbonyl group, a tetrazolyl group, a 4-oxoxadiazolinyl group, a group represented by the following formula: ##STR524##(wherein X represents an oxygen or sulfur atom), or a group represented by --Y--COOR.sub.11 (wherein Y represents a single bond, alkylene, --O-alkylene, --S-alkylene, --SO-alkylene, --CONH-- or CONH-alkylene; and R.sub.11 represents a hydrogen atom, a lower alkyl group or a benzyl group);Ar represents a benzene or naphthalene ring, or an aromatic heterocyclic ring; andn represents an integer between 0 and 2 inclusive,wherein said heterocyclic group independently is selected from 5 and 6 membered rings containing at least one heteroatom selected from the group consisting of N, O and S;wherein said substituent independently is selected from one or two substituents selected from the group consisting of a lower alkyl group, a lower alkoxy group, a halogen atom, an amino group and a nitro group; andwherein at least one of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 contains a carbonyl group.