Patent ID: 7169892
Filing Date: 2007-01-30
Classification: A61K,C07K,Y02P

Abstract:
1. A conjugate comprising a lipid, a peptide, and a water-soluble polymer, wherein the lipid is conjugated to the amino terminus of the peptide by a peptide bond and the water-soluble polymer is conjugated to the carboxy terminus of the peptide by a peptide bond, wherein: the lipid is selected from the group consisting of phospholipids, fatty acids, glycolipids, ceramides, glycerides, and cholesterols; the peptide consists of a sequence selected from the group consisting of Gly-Pro-Gln-Gly-lle-Ala-Gly-Trp-Gly (SEQ ID NO:22), Gly-Pro-Leu-Gly-lle-Ala-Gly-Gln-Gly (SEQ ID NO:17), Gly-Pro-Gln-Gly-lle-Trp-Gly-Gln-Gly (SEQ ID NO:18), and Gly-Hyp-Ala-Ser-Chg-Gln-Ser-Leu-Gly (SEQ ID NO:19), said peptide being a substrate for a secreted mammalian enzyme; and the water-soluble polymer is selected from the group consisting of polyethylene glycols, polyamino acids, polyhydroxyethylamino acids, and polyvinyl pyrrolidones.