Patent ID: 7214679
Filing Date: 2007-05-08
Classification: A61P,C07D

Abstract:
1. A compound of the formula: or the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein: Ar each R m is 0–4; each optionally substituted by one or more R″; wherein each R″ is independently selected from the group consisting of H, alkyl, acyl, aryl, arylalkyl, heteroalkyl, heteroaryl, halo, OR, NR wherein H shown as a ring member is N or CR′ wherein R′ is hydrogen or (a) alkyl, alkenyl, alkynyl, aryl, arylalkyl, acyl, aroyl, heteroaryl, heteroalkyl, heteroalkenyl, heteroalkynyl, heteroalkylaryl, NH-aroyl or halo; or (b) OR, NR Z is -W wherein R wherein two R attached to the same atom may form a 3–8 member carbocyclic or heterocyclic ring and wherein said ring may further be substituted by alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, each optionally substituted with halo, SR, OR, NR each of W and X is an alkylene of 2–6 Å, and each of i and j is independently 0 or 1.