Patent ID: 6828103
Filing Date: 2004-12-07
Classification: A61K,C07K,C12Q,Y10T

Abstract:
A method of screening a human female for increased likelihood of having a favorable response to estrogen replacement therapy with respect to cardiovascular health due to increased HDL levels, comprising:detecting the presence of at least one estrogen receptor alpha polymorphism in said subject, wherein said at least one estrogen receptor alpha polymorphism is selected from the group consisting of the IVS1-354 polymorphism, the IVS1-401 polymorphism, the IVS1-1415 polymorphism, and the IVS1-1505 polymorphism, the presence of said IVS1-354 polymorphism, IVS1-401 polymorphism, IVS1-1415 polymorphism, or IVS1-1505 polymorphism indicating that said subject is more likely to have a favorable response to estrogen replacement therapy with respect to cardiovascular health than a subject with other known estrogen receptor alpha polymorphisms.