Patent ID: 6624309
Filing Date: 2003-09-23
Classification: C07C,C07D

Abstract:
A method of treating cardiac arrhythmia which comprises administering to a mammal in need thereof an effective amount of a compound of the formula whereX is oxygen; Y is a single bond; R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, (aryl)alkyl or (cycloalkyl)alkyl; and R2 is aryl which cannot be substituted with OH or a phenolic ester group and must be substituted with a heterocyclo group at the 4-position which is a fully saturated or unsaturated ring of five or six atoms containing one or two oxygen and/or sulfur atoms and/or one to four nitrogen atoms provided that the total number of hetero atoms in the ring is four or less, or the heterocyclic group is a bicyclic ring wherein the five or six-membered ring containing oxygen and/or sulfur and/or nitrogen atoms as defined above is fused to a benzene ring; â€ƒwith the proviso that (1) the heterocyclo group substituted on the R2 aryl is exclusive of â€ƒwhere X1 is â€”CRaRbâ€” and Y1 is O, S or â€”NRcâ€” where Ra, Rb, and Rc, which may be the same or different, are independently H or C1-4alkyl; (2) R1 is exclusive of aminoalkyl; (3) where R1 is cycloalkyl or (cycloalkyl)alkyl, the cycloalkyl group is unsubstituted or is substituted with alkyl or hydroxy, where the alkyl is unsubstituted or is substituted with halo, alkoxy, aryl, cycloalkyl, hydroxy, nitro, cyano, thiol or alkylthio; and (4) where R1 is aryl, then the heterocyclic group substituted on the R2 aryl is exclusive of â€ƒwhere Rd is H or alkyl.