Patent ID: 7763635
Filing Date: 2010-07-27
Classification: A61K,A61P

Abstract:
1. A once-a-day dosage formulation of a pharmaceutical composition suitable for treating a bladder dysfunction comprising: (a) a first plurality of sugar spheres coated with a layer comprising hydroxypropylmethylcellulose (HPMC) and a pharmaceutically acceptable salt of trospium (Tr (b) a second plurality of sugar spheres coated with a layer comprising hydroxypropylmethylcellulose (HPMC) and a pharmaceutically acceptable salt of trospium (Tr wherein at least a portion of said formulation releases trospium in the lower gastrointestinal (GI) tract; wherein said formulation, when administered orally to a patient suffering from a bladder dysfunction provides average steady state blood levels of Tr wherein the bladder dysfunction is selected from the group consisting of urinary frequency, urgency, nocturia, urge-incontinence associated with detrusor instability, urge syndrome and detrusor hyperreflexia.