Patent ID: 6211371
Filing Date: 2001-04-03
Classification: A61P,C07D,C07F,Y02P

Abstract:
A method of synthesizing compounds having the formula ##STR12##via a 4+1 radical annulation/cyclization wherein the precursor ##STR13##is reacted with an aryl isonitrile having the formula ##STR14##wherein X is selected from the group consisting of Br and I, .tbd.Y is .tbd.N or .tbd.C--R.sup.3, R.sup.1, R.sup.2, and R.sup.6 are independently hydrogen, a normal alkyl group, a branched alkyl group, an allyl group, a benzyl group, an alkynyl group, a propargyl group, an alkoxyl group, a halogen group, a trialkylsilyl group, an amino group, an alkyl amino group, a dialkylamino group, an aminoalkyl group, a cyano group, or R.sup.16 CO--, wherein R.sup.16 is an alkyl group, an alkoxyl group, or an amino group, R.sup.3 is hydrogen, a normal alkyl group, a branched alkyl group, an allyl group, a benzyl group, an alkynyl group, a propargyl group, an alkoxyl group, a halogen group, a trialkylsilyl group, an amino group, an alkyl amino group, a dialkylamino group, an aminoalkyl group, a cyano group, or R.sup.16 CO--, wherein R.sup.16 is an alkyl group, an alkoxyl group, or an amino group, R.sup.4 is an alkyl group, an allyl group, a propargyl group or a benzyl group and R.sup.15 is hydrogen.