Patent ID: 8343710
Filing Date: 2013-01-01
Classification: C08F

Abstract:
1. A photodegradable macromer, comprising: a) a photodegradable group having the formula: where X is O, N or S; R R2-R6 are independently selected from the group consisting of: hydrogen; one or more polymerizable groups, one or more reactive end groups; straight chain, branched or cyclic C1-C20 alkyl, alkenyl, alkynyl groups in which one or more of the carbon atoms are optionally substituted with non-hydrogen substituents and wherein one or more C, CH or CH2 moiety can be replaced with an oxygen atom, a nitrogen atom, an NR′ group, or a S atom; and an optionally substituted aromatic or non-aromatic ring structure, wherein two or more R groups can be linked to form one or more rings which can contain one or more of the same or different heteroatoms; one or more R groups can be optionally substituted with one or more substituent groups selected from halogens; nitro groups; cyano groups; isocyano groups; thiocyano groups; isothiocyano groups; azide groups; —SO R′ can in turn be optionally substituted with one or more groups selected from the group consisting of halogens, nitro groups; cyano groups; isocyano groups; thiocyano groups; isothiocyano groups; azide groups; —SO (b) a backbone structure comprising one or more repeating units, wherein the backbone structure is selected from the group consisting of: poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), poly(styrene), poly(acrylate), poly(methacrylate), poly(vinylether), poly(urethane), polypropylene, polyester and polyethylene which backbone structure is attached to the photodegradable group directly or through a linker; (c) one reactive end group at an end of the macromer; and optionally, (d) one or more therapeutic agents; and optionally (e) one or more caged groups wherein the backbone structure, reactive end group, optional one or more therapeutic agents and optional caged groups are linked to any of the R groups of the photodegradable group wherein the reactive end group is an alkene.