Patent ID: 6649612
Filing Date: 2003-11-18
Classification: A61P,C07C

Abstract:
A biphenyl compound substituted with an aromatic or heteroaromatic radical, characterized in that they correspond to the general formula (I) below: in which:Ar represents an aromatic or heteroaromatic radical chosen from: Z being O or S, R1 represents â€”COR9, R2 and R3, taken together, form a 5- or 6-membered ring, optionally substituted with at least one methyl, R4 represents H, a halogen atom, linear or branched C1-C20 alkyl, â€”OR10, â€”OCOR11 or a polyether radical, R5 represents H, a halogen atom, linear or branched C1-C20 alkyl, â€”OCOR11, OR12, mono- or polyhydroxyalkyl, â€”NO2, â€ƒâ€”(CH2)nâ€”NHCOCH3, â€”CH&boxH;CHâ€”COR13, â€”(CH2)nCOR13, n being 0 to 6, â€”Oâ€”(CH2)mCOR13, â€”Oâ€”(CH2)mOH, m being 1 to 12, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, a polyether radical or a â€”CH2â€” polyether radical, R6 represents H, lower alkyl or â€”OR10, R7 represents H, a halogen atom, linear or branched C1-C20 alkyl, â€”OR10 or â€”OCOR11 or a polyether radical, R9 represents R10 represents H or lower alkyl, R11 represents lower alkyl, R12 represents H, linear or branched C1-C20 alkyl, mono- or polyhydroxyalkyl, or optionally substituted aryl or aralkyl, R13 represents H, lower alkyl, â€”OR10, aryl or râ€² and râ€³, which may be identical or different, represent H, OH, lower alkyl, mono- or polyhydroxyalkyl, optionally substituted aryl, an amino acid residue or a peptide residue, or tâ€² and râ€³, taken together, form a heterocycle, or an optical or geometrical isomer of the said compounds of formula (I).