Patent ID: 6635287
Filing Date: 2003-10-21
Classification: A23B,A61K,A61P,A61Q,Y10S

Abstract:
A process for producing a purified dorman water extract which inhibits proliferation of target cells or target tissue in diseases and conditions selected from the group consisting of carcinoma, psoriasis, seborrheic keratosis, and wart and/or papilloma infection, comprising:(a) providing producer cells or producer tissue which is derived from an organism which is zenogeneic to said target cells or target tissue and which is capable of entering into a dormant state, wherein said organism is a plant selected from the group consisting of Narcissus, Hyacinth carnegie, Amaryllis, and Pancratium; (b) inducing said producer cells or producer tissue to enter a dormant state using high temperature, humidity, or combination thereof, or if already in a dormant state, maintaining said state; and (c) conducting a water extraction from the dormant producer cells, dormant producer tissue or from a medium in which said dormant cells or dormant tissue were incubated to obtain a water-soluble dorman extract, whereby, the extract is fractionated so as to obtain a purified dorman extract which is capable of passing through a 0.45 &mgr;m filter from said dormant producer cells or dormant producer tissue or from a medium in which said dormant cells or tissue was incubated, and whereby, the extract displays a reversible cell anti-proliferative activity without substantial cytotoxicity, wherein the activity is substantially higher in said fraction than the same fraction obtained from said producer cells or tissue, when in a non-dormant state.