Patent ID: 8241844
Filing Date: 2012-08-14
Classification: A61K,A61P,C07H,C07K,C12N,Y02A

Abstract:
1. A method for stimulating lymphocyte cytokine production comprising contacting lymphocytes with an isolated nucleic acid consisting of from 20-84 contiguous nucleotides of a mammalian retroviral sequence, wherein said sequence comprises at least one CpG motif, with the proviso that at least one non-thymidine nucleotide 1, 2, or 3 bases immediately 5′ or immediately 3′ to said CpG motif is substituted with thymidine under conditions wherein said cytokine production is enhanced relative to uncontacted lymphocytes: wherein said nucleic acid consists of a sequence selected from the group consisting of SEQ ID NO: 30, 31, 34, 37, 40, 49, 51.