Patent ID: 9096623
Filing Date: 2015-08-04
Classification: C07F

Abstract:
1. A method for preparing a radiotracer precursor SnADAM comprising the steps of: activating 2-[(4-bromo-2-nitrophenyl)thio]benzoic acid by thionyl chloride (SOCl catalyzing and reducing N,N-Dimethyl-2-[(4-bromo-2-nitrophenyl)thio]-benzamide by using palladium carbon catalyst and hydrogen gas and thus [2-((2-amino-4-bromo-phenyl)thio)benzyl]dimethylacetamide is produced; reducing [2-((2-amino-4-bromo-phenyl)thio)benzyl]dimethylacetamide by borane to produce N,N-dimethyl-2-[(4-bromo-2-nitrophenyl)thio]-dimethylamine; and adding bis(tri-n-butyltin) into N,N-dimethyl-2-[(4-bromo-2-nitrophenyl)thio]-dimethylamine for carrying out substitution reaction and using tris(dibenzylidene-acetone)dipalladium(0) as a catalyst so as to produce [2-((2-Amino-4-tri-n-butyltinphenyl)thio)benzyl]-dimethylamine, which is a radiotracer precursor, SnADAM.