Patent ID: 6159941
Filing Date: 2000-12-12
Classification: A61K,C07D,Y10S

Abstract:
A method of treating a disease related to a high intraocular pressure (IOP), comprising administering to a mammal in need of such treatment an effective amount of a somatostatin receptor ligand of nonpeptide origin having the formula Ia or Ib ##STR71## wherein m is 2, 3, 4, 5 or 6,n is 1, 2 or 3,p is 1, 2, 3, 4, 5 or 6,R.sup.1 and R.sup.2 are independently hydrogen or C.sub.1-6 -alkl optionally substituted with halogen, amino, hydroxy, alkoxy or aryl,X is .dbd.S, .dbd.O, .dbd.NH, .dbd.NCOPh or .dbd.N(CN),A is aryl alk-yloptionally substituted with halogen, amino, hydroxy, nitro, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy or aryl,B is aryl optionally substituted with halogen, amino, hydroxy, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy or aryl,D is aryl, amino, optionally substituted with halogen, amino, hydroxy, C.sub.1-6 -alkyl, C.sub.1-5 -alkoxy or aryl;or a pharmaceutically acceptable salt thereof, wherein the somatostatin receptor ligand of nonpeptide origin selectively binds to the somatostatin receptor protein designated SSTR4.