Patent ID: 8653252
Filing Date: 2014-02-18
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A double-stranded compound comprising a sense strand and an antisense strand, wherein each strand comprises 17-25 nucleotides, wherein at least one of the strands has a 3′ overhang and wherein said compound comprises at least one locked nucleic acid (LNA) monomer located at the 5′ end of the sense strand, the LNA monomer having the structure wherein X is selected from the group consisting of 0, S and NR″, where R″ is H or C B is a nucleobase; Z and Z* are independently absent or selected from the group consisting of an internucleoside linkage group, a terminal group and a protection group; so that when the LNA monomer is located at the 3′ end, Z is a terminal group and Z* is an internucleoside linkage group; when the LNA monomer is located at the 5′ end, Z is absent and Z* is a terminal group; and when the LNA monomer is located within the nucleotide sequence, Z is absent and Z* is an internucleoside linkage group.