Patent ID: 6593352
Filing Date: 2003-07-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula 1, in which:R(1) is H, Cl, Br, I, CN, (C1-C8)-alkyl, (C3-C6)-cycloalkyl, unsubstituted phenyl, or substituted phenyl where the substituted phenyl is substituted by 1-3 substituents chosen from F, Cl, (C1-C3)-alkyl, methoxy and â€”(CF2)aâ€”CF3; and where a is zero, 1, 2 or 3; R(2) is (C1-C8)-alkyl, â€”CbH2bâ€”(C3-C6)-cycloalkyl, unsubstituted â€”CbH2b-phenyl, substituted â€”CbH2b-phenyl, unsubstituted â€”CbH2b-pyridinyl, substituted â€”CbH2b-pyridinyl, unsubstituted â€”CbH2b-thiophenyl, substituted â€”CbH2b-thiophenyl, unsubstituted â€”CbH2b-furanyl, or substituted â€”CbH2b-furanyl where the substituted â€”CbH2b-phenyl, the substituted â€”CbH2b-pyridinyl, the substituted â€”CbH2b-thiophenyl, and the substituted â€”CbH2b-furanyl are each independently substituted by 1-3 substituents chosen from F, Cl, CF3, (C1-C3)-alkyl, methoxy and â€”SO2NR(4)R(5); where R(4) and R(5) independently of one another are H or (C1-C4)-alkyl, and where b is zero, 1, 2, 3 or 4; R(3) is unsubstituted â€”CdH2d-phenyl or substituted â€”CdH2d-phenyl, where the substituted â€”CdH2d-phenyl is substituted by 1-3 substituents chosen from F, Cl, CF3, (C1-C3)-alkyl and methoxy; and where d is 3 or 4; or a pharmaceutically tolerable salt thereof, in any stereoisomeric form, or a mixture of any such compounds in any ratio.