Patent ID: 6586456
Filing Date: 2003-07-01
Classification: A61P,C07D

Abstract:
A compound of formula (I): in whichR1 and R2, which may be identical or different, each independently represent a halogen atom; a hydroxy (C1-C5)alkyl; a (C1-C5)alkyl; an aralkyl in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a (C1-C5)alkoxy; a trifluoromethyl group; a nitro group; a nitrile group; a group â€”SR in which R represents hydrogen, a (C1-C5)alkyl or an aralkyl in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a group â€”Sâ€”COâ€”R in which R represents a (C1-C5)alkyl or an aralkyl radical in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a group â€”COORa in which Ra represents hydrogen or a (C1-C5)alkyl; a group â€”CONRaRb with Ra and Rb as defined above for Ra; a group â€”NRaRb with Ra and Rb as defined above for Ra; a group â€”CONRcRd or â€”NRcRd in which Rc and Rd constitute, with the nitrogen atom to which they are attached, a 5- to 7-membered heterocycle; or a group â€”NHCOâ€”NRaRb with Ra and Rb as defined above for Ra; R3 represents hydrogen or is as defined above for R1 and R2; or alternatively R2 constitutes with R3, when the latter substitutes the phenyl in position 5, a group â€”Xâ€”CH2â€”Xâ€” in which X independently represents a CH2 or an oxygen or sulphur atom; R4 represents hydrogen, a (C1-C5)alkyl; a hydroxymethyl group; a formyl group; a halogen atom; or a (C3-C5)cycloalkyl group; R5 represents an alkynyl of 3 to 6 carbon atoms; R6 represents a (C1-C6)alkyl; a (C1-C6)alkoxy(C1-C3)alkyl; a (C3-C5)cycloalkyl; a (C3-C6)cycloalkyl(C1-C6)alkyl; a (C1-C6)alkylthio(C1-C3)alkyl; a (C1-C6)alkylsulphoxy(C1-C3)alkyl; or a (C1-C6)alkylsulphodioxy(C1-C3)alkyl; R7 represents a phenyl which is unsubstituted, mono-, di- or trisubstituted in position 3, 4 or 5 with a halogen, with a (C1-C5)alkyl, with an â€”Oâ€”CH2â€”Oâ€” group on two neighbouring carbon atoms of the phenyl, with a â€”CF3, â€”NO2 or â€”CN, with a group â€”COOR8 or â€”CONR8R9 or with a group â€‰CH2OR8 in which R8 and R9 represent a (C1-C3)alkyl, OR10 in which R10 represents a (C1-C5)alkyl; or alternatively R7 represents a pyridyl, thiophene, pyrazolyl, imidazolyl, (C3-C5)cycloalkyl or (C3-C6)cycloalkyl(C1-C6)alkyl group; or the acid or base addition salts thereof, the hydrates thereof and/or the solvates thereof.