Patent ID: 8329653
Filing Date: 2012-12-11
Classification: A61K,A61P

Abstract:
1. A method for reducing or inhibiting net beta-amyloid peptide production comprising administering to a subject in need thereof an effective amount of a composition comprising: 1) a polypeptide comprising SEQ ID NO:1, 2) a polypeptide comprising SEQ ID NO:1 lacking Domain C, 3) a polypeptide comprising domains V and VI of SEQ ID NO: 1, 4) a polypeptide comprising SEQ ID NO: 1 lacking a signal sequence, or 5) the expression product of SEQ ID NO: 2, that a) binds to a naturally occurring APP protein and b) inhibits Aβ peptide production, wherein the composition is an amount effective to inhibit Aβ peptide production and wherein the composition is in a form for delivery across the blood brain barrier or is administered by direct injection into the central nervous system.