Patent ID: 7575752
Filing Date: 2009-08-18
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A vaccine comprising a nontoxic, physiologically acceptable carrier and an immunogenic amount of a member selected from the group consisting of: (a) a chimeric nucleic acid molecule of porcine circovirus (PCV1-2) comprising a nucleic acid molecule encoding an infectious, nonpathogenic PCV1 which contains the ORF2 capsid gene of a pathogenic PCV2 in place of the ORF2 capsid gene of the PCV1 nucleic acid molecule; (b) a chimeric nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:2 or its complementary strand; (c) a biologically functional plasmid or viral vector containing a chimeric nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:2 or its complementary strand; and (d) an avirulent, infectious chimeric porcine circovirus made from a chimeric nucleic acid molecule of PCV1-2 wherein the ORF2 capsid gene of PCV1 is replaced with the ORF2 capsid gene of PCV2; in combination with an immunogenic amount of at least one additional porcine antigen.