Patent ID: 6028085
Filing Date: 2000-02-22
Classification: C07D

Abstract:
A compound of formula (I): ##STR9## wherein: R.sup.1 and R.sup.2 groups are each independently hydrogen, C.sub.1-6 alkyl optionally substituted by NR.sup.12 R.sup.13, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkylthio, cyano, nitro, halogen, CF.sub.3, C.sub.2 F.sub.5, NR.sup.12 R.sup.13, CONR.sup.12 R.sup.13, NR.sup.12 COR.sup.13, S(O).sub.p NR.sup.12 R.sup.13, CHO, OCF.sub.3, SCF.sub.3, COR.sup.14, CH.sub.2 OR.sup.14, CO.sub.2 R.sup.14 or OR.sup.14 where p is 1 or 2 and R.sup.12, R.sup.13 and R.sup.14 are independently hydrogen, C.sub.1-6 alkyl, optionally substituted aryl or optionally substituted arylC.sub.1-6 alkyl, orR.sup.1 and R.sup.2 are N.sup.+ I.sup.- R.sup.12 R.sup.13 CR.sup.12 R.sup.13 OCOR.sup.14 where R.sup.12, R.sup.13 and R.sup.14 are as defined above and I.sup.- is a counter ion;n and m are independently 0, 1 or 2;R.sup.3 is hydrogen or C.sub.1-6 alkyl;R.sup.4 is a group of formula (A): ##STR10## in which: R.sup.6 and R.sup.7 are independently hydrogen, C.sub.1-6 alkyl optionally substituted by one or more fluorine atoms, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkoxy, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyloxy, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, C.sub.1-6 alkylthio, C.sub.3-6 cycloalkylthio, C.sub.3-6 cycloalkyl-C.sub.1-6 alkylthio, C.sub.1-6 alkoxy, hydroxy, halogen, nitro, OCF.sub.3, SCF.sub.3, SO.sub.2 CF.sub.3, SO.sub.2 F, formyl, C.sub.2-6 alkanoyl, cyano, optionally substituted phenyl or thienyl, NR.sup.12 R.sup.13, CONR.sup.12 R.sup.13 or CO.sub.2 R.sup.14 where R.sup.12, R.sup.13 and R.sup.14 are as defined above; or R.sup.6 andR.sup.7 form part of an optionally substituted 5- or 6-membered carbocyclic or heterocyclic ring;R.sup.9 and R.sup.10 are independently hydrogen or C.sub.1-6 alkyl;A is a bond, or a group(CH.sub.2).sub.p E, or E(CH.sub.2).sub.p, optionally substituted by C.sub.1-6 alkyl, wherein p is 1 to 4 and E is CO, O or S(O).sub.x wherein x is 0 to 2, or A is NR, CONR, NRCO, NRCONR, CO, CH(OH), C.sub.1-6 alkyl, CH.dbd.CH, CH.dbd.CF, O, S(O).sub.x where x is 1 or 2, NRSO.sub.2 where R is hydrogen or C.sub.1-6 alkyl;or A is an optionally substituted phenyl or an optionally substituted 5- to 7-membered heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur;P.sup.1 is phenyl or a group of formula (B): ##STR11## wherein: R.sup.16 is C.sub.1-6 alkyl, C.sub.1-6 alkoxy, oxygen, NR.sup.17 R.sup.18, NHCONR.sup.17 R.sup.18, NHCOR.sup.19, CR.sup.17 R.sup.18 OCOR.sup.19, OCR.sup.17 R.sup.18 OCOR.sup.19, CR.sup.17 R.sup.18 OCONR.sup.17 R.sup.18, or OCR.sup.17 R.sup.18 OCONR.sup.17 R.sup.18 where R.sup.17, R.sup.18 and R.sup.19 are independently hydrogen, C.sub.1-20 alkyl, optionally substituted aryl or optionally substituted arylC.sub.1-6 alkyl and I.sup.- is a counter ion; and P.sup.2 is phenyl or pyridyl;provided that at least one of R.sup.1, R.sup.2 or P.sup.1 forms a quaternary ammonium group.