Patent ID: 6825373
Filing Date: 2004-11-30
Classification: C07D

Abstract:
A method of preparing an isothiocyanatoformic acid ester product representative by the following formula (2): in which: R4 represents a substituted or non-substituted alkyl group, or a substituted or non-substituted aryl group; R5 represents a substituted or non-substituted alkyl group, a substituted or non-substituted aryl group, or a substituted or non-substituted heterocyclic group; and R6 represents a substituted or non-substituted alkyl group having at least 3 carbon atoms, the method comprising: preparing a first intermediate represented by the following formula (8) by mixing an isothiocyanic acid salt represented by the following formula (5) and a hydroxy derivative represented by the following formula (6), and then adding a chloroformic acid derivative represented by the following formula (7); preparing a second intermediate represented by the following formula (10) from the first intermediate and a compound represented by the following formula (9); and reacting the second intermediate with an alkylating agent represented by one of the following formulas (11) and (12) for preparing the isothiocyanatoformic acid ester product: wherein, in the formula (5), Z represents a sodium atom or a potassium atom, in the formulas (9) and (10), M represents an alkali metal atom, an alkali earth metal atom, an aluminum atom or a magnesium atom, n represents an integer selected from 1 to 3, and, in the formula (11), X represents a halogen atom or SO3Ar, and Ar represents a substituted or non-substituted aryl group, and wherein the second intermediate represented by the formula (10) is obtained as crystals.