Patent ID: 6358501
Filing Date: 2002-03-19
Classification: A61K,A61Q,C08G

Abstract:
A polypeptide-polysiloxane copolymer comprising:a) at least one polysiloxane unit â€ƒwhere the index m is a positive integer in the range m=1-52, and â€ƒis of the general average formula I: â€ƒwhere R1=alkyl radical, R2=R1 and/or -sp- where -sp- is divalent spacer between siloxane and another functional group, where the silicon atom and spacer are linked via a silicon-carbon bond, and the divalent alkylene radical has from 1 to 20 carbon atoms, which is optionally branched and optionally contains double bonds, aromatic rings, or heteroatoms, the indices a and b are integers in the ranges a=0-200 and b=0-50, with the proviso that when a=b=0 and when b=0 and aâ‰ 0, at least one R2=-sp- in each case, and b) at least one polypeptide unit where therm. protein is a structure of the general average formula II: or of the formula III: which is linked to the polysiloxane unit via a divalent functional group-FG- either via the C-terminal end, the N-terminal end or both ends of the polypeptide unit, and which is a structural unit selected from the group consisting of:â€”CH(OH)CH2â€”, â€”CH(OH)CH2Oâ€”, â€”COâ€”, â€”CH(CH2CO2H)COâ€”, â€”NHâ€”, â€”Oâ€”, â€”Sâ€”, â€”CH(NH2)COâ€” and â€”CH(CO2H)NHâ€”and optionally provides additional links between polysiloxane and polypeptide units via the radicals R4 and/or R5 whereR3=R4 or R5, where R4=is identical to a residue of an amino acid and â€”(CH2)4â€”NHâ€”R6, whereR6=H (lysine) or R5=â€”CH2â€”CH2â€”COâ€”R6 where R6=OH (glutamic acid) or â€ƒc, d, e and f are positive integers including 0, with the proviso that the indices c, d, e in formula II and c, d and f in formula III are not all 0, and the molecular weight of the polypeptide unit is between 250 and 9000 and the weight ratio of polysiloxane units and polypeptide units in the polypeptide-polysiloxane copolymer is between 1:99 and 99:1.