Patent ID: 8211471
Filing Date: 2012-07-03
Classification: A61K,A61P

Abstract:
1. A process for the production of cross-linked beadlets containing vitamin A which comprises the steps of: (a) forming an emulsion containing vitamin A, an emulsifier and a reducing sugar, (b) converting the emulsion to droplets, (c) coating the droplets with finely dispersed calcium silicate powder, (d) separating a dry particulate form of beadlets obtained by step (c) from remaining finely dispersed calcium silicate powder, and (e) heat treating the dry particulate form of beadlets to obtain a maximum beadlet temperature in the range of from 90° C. to 140° C. within a time period of from 30 seconds to 30 minutes to thereby form a final beadlet having a total vitamin A concentration of from 800,000 IU vitamin A/g beadlet to 1,500,000 IU vitamin A/g beadlet with a core and a surface region, wherein the surface region contains less than 10% of the total vitamin A concentration of the final beadlet.