Patent ID: 6110969
Filing Date: 2000-08-29
Classification: C07C

Abstract:
A .omega.-cycloalkyl-prostaglandin E.sub.2 derivatives of the formula (I) ##STR444## wherein R is carboxy or hydroxymethyl;R.sup.1 is oxo, methylene or halogen atom;R.sup.2 is hydrogen atom, hydroxy or C1-4 alkoxy; R.sup.3 is (i) hydrogen atom, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl or (v) C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl, each substituted by 1-3 substituents, being same or different, selected from (1)-(5):(1) halogen atom,(2) C1-4 alkoxy,(3) C3-7 cycloalkyl,(4) phenyl, or(5) phenyl substituted by 1-3 substituents selected from halogen atom, C1-4 alkyl, C1-4 alkoxy, nitro or trifluoromethyl;n is 0-4;is single bond or double bond;is double bond or triple bond;is single bond, double bond or triple bond;with the proviso that,(1) when 5-6 position is triple bond, 13-14 position is not triple bond,(2) when 13-14 position is double bond, double bond represent E, Z or EZ mixture form; non-toxic salt thereof, prodrug thereof and cyclodextrin clathrate thereof.