Patent ID: 8182829
Filing Date: 2012-05-22
Classification: A61L,A61M,A61P

Abstract:
1. An implantable medical device comprising: a device body; an optional primer layer disposed over the device body; a drug reservoir layer disposed over the device body or the primer layer, if opted, wherein the drug reservoir layer comprises: i) a high molecular weight copolymer of L-lactide, D,L-lactide, or meso-lactide with e-caprolactone or trimethylene carbonate, at least a portion of which is substituted with a pendant hemocompatible and/or a prohealing moiety; or, ii) a blend of a high molecular weight copolymer of L-lactide, D,L-lactide, or meso-lactide with e-caprolactone or trimethylene carbonate and a low molecular weight copolymer of lactic acid or glycolic acid with e-caprolactone or trimethylene carbonate at least a portion of which is substituted with a pendant hemocompatible and/or prohealing moiety; or iii) a high molecular weight copolymer of L-lactide, D,L-lactide, or meso-lactide with e-caprolactone or trirmethylene carbonate, and a topcoat layer comprising a low molecular weight polymer of lactic acid or glycolic acid with e-caprolactone or trimethylene carbonate at least a portion of which is substituted with a pendant hemocompatible and/or prohealing moiety; wherein the drug reservoir layer or the topcoat layer of i), ii) or iii) comprises the copolymer of i), ii) or iii) having the formula: wherein: L comprises a Linker; and, m is from about 0.01 to about 0.99; n is from about 0.99 to about 0.01; and n+m=1.