Patent ID: 6111108
Filing Date: 2000-08-29
Classification: C07D,Y02P

Abstract:
A method for isolating Camptothecin, said method comprising the steps of:(a) selecting a substrate for extracting Camptothecin therefrom,(b) loading the selected substrate into an extraction vessel,(c) introducing carbon dioxide into said vessel in contact with said substrate and at a temperature and pressure exceeding its critical temperature and pressure to cause the carbon dioxide to reach a supercritical state, whereby to produce an initial extraction product,(d) separating said initial extraction product from a remaining portion of said substrate,(e) adding a solvent to said vessel and pressurizing the vessel to at least approximately 350 atm to extract Camptothecin from said portion of the substrate and provide a subsequent extraction product containing the extracted Camptothecin, and thereafter(f) collecting said subsequent extraction product from the vessel.