Patent ID: 6521643
Filing Date: 2003-02-18
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 and R2 are the same or different and each is hydrogen, lower alkyl, lower alkoxy, cyano, lower alkoxycarbonyl, carboxy, lower haloalkyl, hydroxy(lower)alkyl, hydroxy, nitro, amino, mono or di(lower)alkylamino, protected hydroxy or lower alkyl substituted by protected hydroxy; X is a single bond or a group of the formula selected from the group consisting of wherein R4 is hydrogen or acyl; ring A is heterocycle or arylene wherein said heterocycle and arylene may be substituted by suitable substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and guanidino which may be substituted by suitable substituent(s); and R3 is a group of the formula selected from the group consisting of wherein R5 is hydrogen, lower alkyl, lower alkylthio, amino which may be substituted by suitable substituent(s) or aromatic heterocyclic group, or when â€ƒmay form a bicyclic group selected from the group consisting of â€ƒwherein said bicyclic group may be substituted by suitable substituent(s) selected from the group consisting of lower alkyl and aryl, R6 and R7 are the same or different and each is hydrogen, lower alkyl, cyano, amino, hydroxy, acyl or amidino which may be substituted by suitable substituent(s), and R8 is thiazolinyl or pyridyl, or a pharmaceutically acceptable salt thereof.