Patent ID: 6300339
Filing Date: 2001-10-09
Classification: A61K,C07D

Abstract:
A compound of formula (Ia) ##STR13##wherein ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl, C.sub.1-12 alkoxy, aryl, aryloxy aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC.sub.1-12 alkyl, amino, acylamino, C.sub.1-12 alkylamino, arylamino, aralkylamino, aminoC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C.sub.1-12 alkoxyC.sub.1-12 alkyl, aryloxyC.sub.1-12 alkyl, aralkoxyC.sub.1-12 alkyl, C.sub.1-12 alkylthio, thioC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, --COR.sup.11, or --SO.sub.2 R.sup.2, wherein R.sup.11 and R.sup.12 independently of each other are selected from hydroxy, halogen, perhalomethyl, C.sub.1-6 alkoxy or amino optionally substituted with one or more C.sub.1-6 alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;ring B represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl, C.sub.1-12 alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC.sub.1-12 alkyl, amino, acylamino, C.sub.1-12 alkyl-amino, arylamino, aralkylamino, aminoC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C.sub.1-12 alkoxyC.sub.1-12 alkyl, aryloxyC.sub.1-12 alkyl, aralkoxyC.sub.1-12 alkyl, C.sub.1-12 alkylthio, thioC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, --COR.sup.11,or --SO.sub.2 R.sup.12, wherein R.sup.11 and R.sup.12 independently of each other are selected from hydroxy, halogen, perhalomethyl, C.sub.1-6 alkoxy or amino optionally substituted with one or more C.sub.1-6 alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;X is a valence bond, --(CHR.sup.9)--, --(CHR.sup.9)--CH.sub.2 --, --CH.dbd.CH--, --(CHR.sup.9)--CH.dbd.CH--, --(CHR.sup.9)--CH.sub.2 --CH.sub.2 --, --CH.dbd.(CR.sup.9)--, wherein R.sup.9 is hydrogen, halogen, hydroxy, nitro, cyano, formyl, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C.sub.1-12 alkyl-amino, arylamino, aralkylamino, aminoC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C.sub.1-12 alkoxyC.sub.1-12 alkyl, aryloxyC.sub.1-12 alkyl, aralkoxyC.sub.1-12 alkyl, C.sub.1-12 alkylthio, thioC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, --COR.sup.11, or --SO.sub.2 R.sup.12, wherein R.sup.11 and R.sup.12 independently of each other are selected from hydroxy, halogen, C.sub.1-6 alkoxy, amino optionally substituted with one or more C.sub.1-6 alkyl, perhalomethyl or aryl;T is >CH-- or >C<;Z is --CH.sub.2 -- or .dbd.CH--;Q is --O--, --S--, >SO.sub.2, >NR.sup.16, wherein R.sup.16 is hydrogen or C.sub.1-6 alkyl;k is 1 or 2;T.dbd..dbd.(Z).sub.p and T.dbd..dbd.(CH.sub.k) independently of each other represents a single bond or a double bond, provided that both are not a double bond at the same time;Ar represents arylene, heteroarylene, or a divalent heterocyclic group optionally substituted with one or more C.sub.1-6 alkyl or aryl;R.sup.5 represents hydrogen, hydroxy, halogen, C.sub.1-12 alkoxy, C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl or aralkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R.sup.5 forms a bond together with R.sup.6 ;R.sup.6 represents hydrogen, hydroxy, halogen, C.sub.1-12 alkoxy, C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl, acyl or aralkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R.sup.6 forms a bond together with R.sup.5 ;R.sup.7 represents hydrogen, C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl, aryl, aralkyl, C.sub.1-12 alkoxyC.sub.1-12 alkyl, C.sub.1-12 alkoxycarbonyl, aryloxycarbonyl, C.sub.1-12 alkylaminocarbonyl, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or heteroaralkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;R.sup.8 represents hydrogen, C.sub.1-12 alkyl, C.sub.4-12 -alkenynyl, C.sub.2-12 -alkenyl, C.sub.2-12 -alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or heteroaralkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;Y represents oxygen, sulphur or NR.sup.10, where R.sup.10 represents hydrogen, C.sub.1-12 alkyl, aryl, hydroxyC.sub.1-12 alkyl or aralkyl groups or when Y is NR.sup.10, R.sup.8 and R.sup.10 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C.sub.1-6 alkyl;p is an integer ranging from 0 to 1, n is an integer ranging from 0 to 3 and m is an integer ranging from 0 to 1;provided that A or B does not represent phenyl;or a pharmaceutically acceptable salt thereof.