Patent ID: 6420344
Filing Date: 2002-07-16
Classification: C07H

Abstract:
A compound of the formula:R1â€”Zâ€”R2 wherein: each of R1 and R2 is independently a monosaccharide residue or an oligosaccharide residue; Z is an aliphatic polyamino linker that is the residue of an aliphatic polyamine comprising at least two amino groups, wherein Z is substituted with at least one substituent selected from the group consisting of halogen, lower alkyl. Alkoxy, acyloxy, hydroxy, acetamido, amino, acyl, nitro, mercapto, benzyloxy, benzyl and phenyl provided that there is at least one primary or secondary amino group per saccharide residue to be conjugated, and each of R1 and R2 is linked through its anomeric carbon at its 1 position to a different amino group of the aliphatic polyamino linker to form a glycosidic bond; provided that when each of R1 and R2 is the same and is a glucose, galactose, mannose, or cellobiose residue, Z is the residue of an aliphatic polyamine other than ethylenediamine or diaminopropane; and pharmaceutically acceptable salts and prodrugs thereof.