Patent ID: 6924285
Filing Date: 2005-08-02
Classification: A61P,C07D

Abstract:
1. A compound of the general formula wherein R R R a cyclobutyl, cyclopentyl or cyclohexyl group which is substituted in each case by a group R an azetidin-3-yl group which is substituted in the 1 position by the group R a pyrrolidin-3-yl group which is substituted in the 1 position by the group R a piperidin-3-yl group which is substituted in the 1 position by the group R a piperidin-4-yl group which is substituted in the 1 position by the group R or a tetrahydrofuran-3-yl, tetrahydropyran-3-yl or tetrahydropyran-4-yl group, R a hydroxy group, a C a methoxy group substituted by 1 to 3 fluorine atoms, an ethyloxy group substituted by 1 to 5 fluorine atoms, a C a C a tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy or tetrahydropyran-4-yloxy group, a tetrahydrofuranyl-C a C or a C X denotes a nitrogen atom, and by the aryl groups mentioned in the definition of the above groups is meant in each case a phenyl group which is mono- or disubstituted by R by the heteroaryl groups mentioned in the definition of the above groups is meant a pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl group, while said heteroaryl groups are each mono- or disubstituted by the group R said pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl groups may be substituted in each case by one or two C unless otherwise stated, said alkyl groups may be straight-chained or branched, with the proviso that the compound 4-[(3-chloro-4-fluoro-phenyl)amino]-6((S)-tetrahydrofuran-3-yloxy)-7-hydroxy-quinazoline is excluded, their tautomers, their stereoisomers, their mixtures and their salts.