Patent ID: 8410163
Filing Date: 2013-04-02
Classification: A61K,A61P,C07D

Abstract:
1. A method for inhibiting tubulin polymerization comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula A or its salt, where: X is CN or CONH m and n independently are 0, 1, 2, or 3, provided that at least one of m and n is not 0; and each R independently is selected from the group consisting of halo, cyano, nitro, optionally substituted alkyl, —OR′, —SR′, —C(O)OR′, and —NR′R″, where R′ is optionally substituted alkyl, and R″ is hydrogen or alkyl, or two adjacent R groups on the same phenyl group together are methylenedioxy.