Patent ID: 6369230
Filing Date: 2002-04-09
Classification: B01J,C07D

Abstract:
A process for preparing a 4-substituted pyridine compound, which comprises:first reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an &agr;-unsaturated acid of the formula whereinR3 and R4, which may be the same as or may differ from one another, are each â€”H or a C1-C4 alkyl group; so as to form a corresponding first 1,4-substituted pyridine betaine; second reacting the 1,4-substituted betaine with a nucleophile to displace the leaving group and form a second 1,4-substituted-pyridine betaine; and treating the second 1,4-substituted betaine to remove the 1-substituent and form the 4-substitued pyridine compound.