Patent ID: 6642377
Filing Date: 2003-11-04
Classification: C07D,Y02P

Abstract:
A process for producing a basic antibiotic.inorganic acid salt (I) wherein the basic antibiotic.inorganic acid salt (I) is selected from the group consisting of:(1) cefotiam hydrochloride; (2) cefmenoxime hydrochloride; (3) cefozopran hydrochloride; (4) cefpirome sulfate; (5) cefepime hydrochloride; (6) cefoselis sulfate; (7) cefotiam hexetil hydrochloride; (8) cefetamet pivoxil hydrochloride; (9) cefcapene pivoxil hydrochloride; (10) talampicillin hydrochloride; (11) bacampicillin hydrochloride; (12) lenampicillin hydrochloride; (13) pivmecillinam hydrochloride; and (14) (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-{(2S,4S)-2-[(3R)-pyrrolidine-3-yl-(R)-hydroxy]methyl}pyrrolidine-4-ylthio]-1-carbapen-2-em-3-carboxylic acid.hydrochloride, said process comprising: subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: â€ƒwherein the ring A represents the basic antibiotic; R10 represents a protected functional group; Akâ€”E represents the alkali earth metal; and B represents the inorganic acid; and producing said basic antibiotic.inorganic acid salt (I).