Patent ID: 6498174
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A compound of formula (I), or a tautomeric form, pharmaceutically acceptable salt, or solvate thereof, wherein;R1 is hydrogen or C1-3alkyl; R2 is hydrogen, or C1-8alkyl optionally substituted by one or more halogens; R3 is C1-6alkyl, C4-7cycloalkyl or cycloalkenyl, â€”OC1-6alkyl, â€”NRâ€²Râ€² (where each Râ€² is independently hydrogen or C1-3alkyl), a 5 or 6 membered heterocyclic group containing at least one oxygen, nitrogen, or sulfur ring atom (optionally substituted by one or more halogen, C1-6alkyl optionally substituted by one or more halogens, â€”OC1-6alkyl optionally substituted by one or more halogens, â€”CN, or â€”NO2), or phenyl (optionally substituted by one or more halogen, C1-6alkyl optionally substituted by one or more halogens, â€”OC1-6alkyl optionally substituted by one or more halogens, â€”CN, or â€”NO2); R4 is a 5 or 6 membered heterocyclic group containing at least one oxygen, nitrogen, or sulfur ring atom (optionally substituted by one or more halogen, C1-6alkyl optionally substituted by one or more halogens, â€”OC1-6alkyl optionally substituted by one or more halogens, â€”CN, or â€”NO2), or phenyl (optionally substituted by one or more halogen, C1-6alkyl optionally substituted by one or more halogens, â€”OC1-6alkyl optionally substituted by one or more halogens, â€”NRâ€²Râ€², â€”CN, or â€”NO2); R5 is hydrogen, halogen, or C1-3alkyl optionally substituted by one or more halogens; R6 is hydrogen or C1-3alkyl; X is O or S; and n is 1, 2, or 3.