Patent ID: 7524509
Filing Date: 2009-04-28
Classification: A61K,A61P,C12N

Abstract:
1. An immunogenic composition for inducing an immunological response to an antigen, said composition comprising the antigen and an effective amount of proteosome-lipopolysaccharide adjuvant, wherein the proteosome-lipopolysaccharide adjuvant enhances the immunological response to the antigen, wherein the antigen and the proteosome-lipopolysaccharide adjuvant are separate chemical entities, and wherein the proteosome-lipopolysaccharide adjuvant is formed from an outer membrane proteosome complexed with a lipopolysaccharide preparation, wherein both the proteosome and the lipopolysaccharide preparation are from gram-negative bacteria, which proteosome-lipopolysaccharide adjuvant has a final lipopolysaccharide content by weight as a percentage of the total proteosome protein of at least 13%.