Patent ID: 9162995
Filing Date: 2015-10-20
Classification: C07D

Abstract:
1. A method of manufacturing a polyfunctional amine selected from bis(2-(piperazin-1-yl)ethyl)amine (BPEA) (3-(piperazin-1-yl)propyl)amine, bis(4-(piperazin-1-yl)butyl)amine, bis(5-(piperazin-1-yl)pentyl)amine, bis(6-(piperazin-1-yl)hexyl)amine, bis(1-(piperazin-1-yl)propan-2-yl)amine, and bis(2-(piperazin-1-yl)propyl)amine, comprising the steps of: (a) providing an amine selected from 2-(piperazin-1-yl)ethanamine (AEP), 3-(piperazin-1-yl)propan-1-amine, 4-(piperazin-1-yl)butan-1-amine, 5-(piperazin-1-yl)pentan-1-amine, 6-(piperazin-1-yl)hexan-1-amine, 1-(piperazin-1-yl)propan-2-amine and 2-(piperazin-1-yl)propan-1-amine; and (b) reacting the amine in the presence of a hydrogenation/dehydrogenation catalyst under conditions effective to cause the formation of polyfunctional amine, wherein the catalyst is selected from platinum, palladium, rhodium, ruthenium, nickel, iron, copper, chromium, molybdenum, cobalt, osmium, and iridium, and the catalyst optionally comprises a metal promoter selected from Group IA, Group IIA, Group IIIA, Group IVA, Group VA, Group VIA, Group IB, Group JIB Group IIIB, Group IVB, Group VB, Group VIB, Group VIIB and Group VIIIB of the Periodic Table (IUPAC format), and metal oxides thereof.