Patent ID: 9005626
Filing Date: 2015-04-14
Classification: A61K,A61P

Abstract:
1. A method for making a foamable liquid composition for topical use, comprising: a. providing a liquid composition comprising: b. mechanically creating a foam of the liquid composition; c. scanning the foam surface to determine the stability and the volume of the foam and thereby determining the foam volume and the foam stability using a SITA measurement method without the use of a propellant; d. correlating the foam volume and the foam stability as specified by the SITA measurement method with the pharmaceutical properties of the foam; e. varying the concentration of at least one of the pharmaceutically active agent, the isopropanol, the further solvent, or the foaming agent; f. repeating steps b through e until 250 ml of the liquid composition, after the mechanical creation of the foam, has a foam density between 0.05 g/ml and 0.8 g/ml, foam volume of at least 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C.