Patent ID: 6140320
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A acompound of formula (I): ##STR57## or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein:A is O or S;W is N or CR.sup.3 ;X is N or CR.sup.4 ;Y is N or CR.sup.5 ;Z is N or CR.sup.6 ;provided that if two of W, X, Y, mnd Z are N, then the remaining are other than N;R.sup.a is selected from H, CF.sub.3, CF.sub.2 H, C.sub.1-4 alkyl, C.sub.3-5 cycloalkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, and phenyl substituted with 0-2 R.sup.10 ;R.sup.b is selected from H, CF.sub.3, CF.sub.2 H, C.sub.1-4 alkyl, C.sub.3-5 cycloalkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, and phenyl substituted with 0-2 R.sup.10 ;alternatively, R.sup.a and R.sup.b together form --(CH.sub.2)n--;R.sup.1 is selected from CF.sub.3, CF.sub.2 H, C.sub.1-4 alkyl, C.sub.3-5 cycloalkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl;R.sup.2 is selected from --C.tbd.C--R.sup.8, --CH.dbd.CR.sup.7 R.sup.8, --(CH.sub.2).sub.p CHR.sup.7 R.sup.8, --CH.sub.7 C.tbd.C--R.sup.8, --CHR.sup.7 CH.dbd.CHR.sup.8, and --CH.dbd.CHCHR.sup.7 R.sup.8 ;provided that when either of R.sup.a or R.sup.b is phenyl, then R.sup.1 is other than C.sub.1-4 alkyl and C.sub.3-5 cycloalkyl and R.sup.2 is other than --(CH.sub.2).sub.p CHR.sup.7 R.sup.8 ;R.sup.3 is selected from H, F, Cl, Br, I, C.sub.1-3 alkoxy, and C.sub.1-3 alkyl;R.sup.4 is selected from H, F, Cl, Br, I, C.sub.1-3 alkyl substituted with 0-3 R.sup.11, C.sub.2-3 alkenyl, C.sub.2-3 alkynyl, C.sub.1-3 alkoxy, OCF.sub.3, --CN, NO.sub.2, CHO, C(O)CH.sub.3, C(O)CF.sub.3, C(O)NH.sub.2, C(O)NHCH.sub.3, NR.sup.7 R.sup.7a, NR.sup.7 C(O)OR.sup.7b, C(O)OR.sup.7, S(O).sub.p R.sup.7, SO.sub.2 NHR.sup.7, NR.sup.7 SO.sub.2 R.sup.7b, phenyl substitutes with 0-2 R.sup.10, and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R.sup.10 ;alternatively, R.sup.3 and R.sup.4 together form --OCH.sub.2 O--;R.sup.5 is selected from H, F, Cl, Br, and I;alternatively, R.sup.4 and R.sup.5 together form --OCH.sub.2 O-- or a fused benzo ring;R.sup.6 is selected from H, OH, C.sub.1-3 alkoxy, --CN, F, Cl, Br, I, NO.sub.2, CF.sub.3, CHO, C.sub.1-3 alkyl, and C(O)NH.sub.2 ;R.sup.7, at each occurrence, is selected from H and C.sub.1-3 alkyl;R.sup.7a, at each occurrence, is seleced from H and C.sub.1-3 alkyl;R.sup.7b, at each occurrence, is C.sub.1-3 alkyl;R.sup.8, at each occurrence, is selected from H, C.sub.1-6 alkyl substituted with 0-3 R.sup.11, CH(--OCH.sub.2 CH.sub.2 O--), C.sub.2-6 alkenyl, C.sub.3-7 cycloalkyl substituted with 0-2 R.sup.9, phenyl substituted with 0-2 R.sup.10, and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R.sup.10 ;R.sup.9, at each occurrence, is selected from H.sup.2, OH, C.sub.1-3 alkoxy, C.sub.1-3 alkyl, and F;R.sup.10, at each occurrence, is selected from OH, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, F, Cl, Br, I, CN, NR.sup.7 R.sup.7a, and C(O)CH.sub.3 ;R.sup.11, at each occurrence, is selected from OR.sup.7, CN, F, Cl, Br, I, NO.sub.2, NR.sup.7 R.sup.7a, CHO, C(O)CH.sub.3, C(O)NH.sub.2 ;n, at each occurrence, is selected from 1, 2, 3, 4, and 5; and,p, at each occurrence, is selected from 0, 1, and 2.