Patent ID: 6410550
Filing Date: 2002-06-25
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula R1 is hydrogen, (C1-C6)alkyl, unconjugate (C3-C6)alkenyl, XC(&boxH;O)R13, benzyl or â€”CH2CH2â€”Oâ€”(C1-C4)alkyl; R2 and R3, together with the carbons to which they are attached, form a four to seven membered monocyclic, or ten to fourteen membered bicyclic, carbocyclic ring that can be saturated or unsaturated, wherein from one to three of the nonfused carbon atoms of said monocyclic rings, and from one to five of the carbon atoms of said bicyclic rings that are not part of the benzo rings shown in formula I, may optionally and independently be replaced by a nitrogen, oxygen or sulfur, and wherein said monocyclic and bicyclic rings may optionally be substituted with one or more substituents that are selected, independently, from (C1-C6) alkyl optionally substituted with from one to seven fluorine atoms; (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms; nitro, cyano, halo, (C2-C6)alkenyl, (C2-C6)alkynyl, hydroxy, amino, (C1-C6)alkylamino and ((C1-C6)alkyl)2amino, â€”CO2R4, â€”CONR5R6, â€”SO2NR7R8, â€”C(&boxH;O)R13 and â€”XC(&boxH;O)R13; wherein each R4, R5, R6, R7, R8 and R13 is selected, independently, from hydrogen and (C1-C6) alkyl, or R5 and R6, or R7 and R8 together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, morpholine, azetidine, piperazine, â€”Nâ€”(C1-C6)alkylpiperazine or thiomorpholine ring, or a thiomorpholine ring wherein the ring sulfur is replaced with a sulfoxide or sulfone; and each X is, independently, (C1-C6)alkylene; or a pharmaceutically acceptable salt thereof.