Patent ID: 6689579
Filing Date: 2004-02-10
Classification: A61K,C07H,C07K

Abstract:
An isolated nucleic acid molecule comprising a first polynucleotide sequence at least 95% identical to a second polynucleotide sequence selected from the group consisting of:(a) a polynucleotide sequence encoding the Neutrokine-&agr; polypeptide having the complete amino acid sequence in FIGS. 1A and B (SEQ ID NO:2); (b) a polynucleotide sequence encoding the Neutrokine-&agr; polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC No. 97768 deposited on Oct. 22, 1996; (c) a polynucleotide sequence encoding the Neutrokine-&agr; polypeptide extracellular domain; (d) a polynucleotide sequence encoding a soluble Neutrokine-&agr; polypeptide comprising the extracellular and intracellular domains but lacking the transmembrane domain; and (e) a polynucleotide sequence complementary to the full length of any of the polynucleotide sequences in (a), (b), (c) or (d) above; wherein said first polynucleotide encodes a polypeptide that stimulates B lymphocyte proliferation, differentiation, or survival.