Patent ID: 8778336
Filing Date: 2014-07-15
Classification: A61K,A61P,A61Q,C12N,C12Y

Abstract:
1. A stabilized protease product comprising a protease wherein the protease has been immobilized to a carbomer by reacting a portion of the primary amines of the protease with the carboxyl groups of the carbomer and wherein a portion of the remaining primary amines of the protease have been crosslinked via an amine reactive crosslinking reagent, wherein the crosslinking is performed by 1% to 5% by weight of the amine reactive crosslinking reagent and the amine reactive crosslinking reagent is selected from the group consisting of Dimethyl adipimidate (DMA), Bis(Sulfosuccinimidyl) suberate (BS3), Dimethyl Suberimidate (DMS), Dimethyl pimelimidate (DMP) and Disuccinimidyl suberate (DSS).