Patent ID: 6433149
Filing Date: 2002-08-13
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method for removing osteoblast cadherin (OB-cadherin) expressing metastatic cells from a biological sample, comprising the steps of:(a) contacting a biological sample cont OB-cadherin expressing metastatic cells with an antimetastatic agent that comprises: (i) an OB-cadherin cell adhesion recognition (CAR) sequence or an analogue thereof that is at least 50% identical to SEQ ID NO:50 such that the ability to inhibit OB-cadherin mediated cell adhesion is not substantially diminished relative to SEQ ID NO:50; or (ii) an antibody or antigen-binding fragment thereof that specifically binds to SEQ ID NO:50; wherein the contact takes place under conditions and for a time sufficient to allow OB-cadherin expressing cells within the biological sample to bind to the antimetastatic agent; and (b) separating OB-cadherin expressing metastatic cells bound to the antimetastatic agent from the biological sample.