Patent ID: 6114327
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR12## wherein n is 2, 3, 4 or 5;R is independently at each occurrence hydroxy, thiol, halo, cyano, cyano(C.sub.1 -C.sub.4)alkyl, amino, halo(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1 -C.sub.4)alkylamino, azido, carboxy, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, carbamoyl, carbamoyloxy, carbamoylamino, N-(C.sub.1 -C.sub.4)alkylcarbamoyl, --OCF.sub.3, OCCl.sub.3, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonylamino, formyl, C.sub.2 -C.sub.4 alkanoyl, formyloxy, C.sub.2 -C.sub.4 alkanoyloxy, formylamino, C.sub.2 -C.sub.4 alkanoylamino, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, pyrrolidino, piperidino or morpholino;R.sup.0 is hydrogen, halo, C.sub.1 -C.sub.4 alkyl, or C.sub.1 -C.sub.4 alkoxy;R.sup.1 is hydrogen, C(O)(C.sub.1 -C.sub.6 alkyl), SO.sub.2 (C.sub.1 -C.sub.6 alkyl), or C(O)CF.sub.3 ;R.sup.2 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, halo(C.sub.1 -C.sub.6)alkyl, phenyl, substituted phenyl, furyl, thienyl, thiazol-2-yl, 2-acetamido-4-methyl-thiazol-5-yl, 1,3,4-thiadiazol-2-yl, 2-methyl-1,3,4-thiadiazol-5-yl, 2-methylamino-1,3,4-thiadiazol-5-yl, a group of the formula ##STR13## SO.sub.2 R.sup.3, where R.sup.3 is C.sub.1 -C.sub.10 alkyl, halo(C.sub.1 -C.sub.6)alkyl, C.sub.3 -C.sub.7 cycloalkyl, substituted C.sub.3 -C.sub.7 cycloalkyl, phenyl, substituted phenyl, naphthyl, thienyl, thiazolidinyl, furyl, pyrrolidino, piperidino, morpholino, or NR.sup.4 R.sup.5.sub.1 where R.sup.4 and R.sup.5 are independently C.sub.1 -C.sub.4 alkyl or R.sup.4 and R.sup.5 taken together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino ring; andX is NOZ or CHY, where Y is COZ, CO.sub.2 Z, or S(O).sub.m Z, where m is 0, 1, or 2 and Z is hydrogen or C.sub.1 -C.sub.10 alkyl;ora pharmaceutically acceptable salt thereof.