Patent ID: 6410219
Filing Date: 2002-06-25
Classification: A61K,A61L,A61P,C07D,C12N

Abstract:
An in vitro method of inactivating a pathogen in mammalian blood or a mammalian blood product comprising:(a) contacting in vitro mammalian blood or a mammalian blood product, with a pathogen inactivating amount of a first compound that has a nucleic acid binding ligand and a moiety selected from the group consisting of a mustard group, an aziridinium, and an aziridine, which when incubated with the blood or blood product results in the inactivation of at least 1 log of a pathogen present in the blood or blood product, if any, (b) and recovering the pathogen inactivated blood or blood product, wherein the recovered blood or blood product has substantially the same biological activity such that it is suitable for therapeutic use in a mammal, wherein the first compound has a greater inactivation efficiency against R17 than a second compound containing a mustard group, aziridinium, or aziridine that lacks the nucleic acid binding ligand.