Patent ID: 6509358
Filing Date: 2003-01-21
Classification: C07D

Abstract:
A compound of formula I having the structure (a) phenyl optionally substituted with 1-3 Y groups; (b) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; (c) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; or (d) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, having a second phenyl ring fused to the heterocyclic ring, optionally substituted with 1-2 Y groups; Y is hydroxy, halogen, cyano, â€”SOmR2, â€”SOnNR2R3, â€”NHSO2R2, â€”NR2R3, alkyl of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkoxy of 1-10 carbon atoms, arylalkoxy, â€”COR2, or â€”CO2R2; X is â€”OCH2â€” or a bond; R1 is (a) alkyl of 1-10 carbon atoms, optionally substituted with 1-5 groups selected from the group consisting of halogen; hydroxy; phenyl optionally mono- or di-substituted with Z; oxo; â€”CO2H; â€”CO2R2; amino; â€”NR2R3; and â€”NHCOR2; (b) cycloalkyl of 3-8 carbon atoms; (c) arylalkyl wherein the alkyl moiety contains 1-10 carbon atoms; or (d) heterocycle or heterocyclealkyl, wherein the alkyl moiety contains 1-6 carbon atoms, and the heterocycle is i) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; ii) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; or iii) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, having a second phenyl ring fused to the heterocyclic ring, optionally substituted with 1-2 Y groups; R2 and R3 are each, independently, hydrogen, alkyl of 1-10 carbon atoms, or cycloalkyl of 3-8 carbon atoms; Z is hydroxy, halogen, alkyl of 1-10 carbon atoms, â€”CO2R2, benzyloxy, â€”NHC(O)NHR2, â€”NR2R3, â€”OR2, â€”COR2, â€”S(O)mR2; or â€”S(O)nNR2R3; m=0-2; n=1-2 or a pharmaceutically acceptable salt thereof.