Patent ID: 7462638
Filing Date: 2008-12-09
Classification: A61K

Abstract:
1. A method for treating pain in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of an IκB-kinase inhibitor of the compound of formula Ia: or a stereoisomeric form thereof or a mixture of stereoisomeric forms in any ratio, or a physiologically tolerated salt thereof, wherein, E is CH; M is N; R21 is hydrogen, halogen, —(C —CN, —CF —OR —N(R —(C —C(O)—R —S(O) R31 is hydrogen, halogen, —(C —CN, —CF —OR —N(R —C(O)—R —S(O R22 is a heteroaryl radical selected from 3-hydroxypyrro-2,4-dione, imidazole, imidazolidine, imidazoline, indazole, isothiazole, isothiazolidine, isoxazole, 2-isoxazolidine, isoxazolidine, isoxazolone, morpholine, oxazole, 1,3,4-oxadiazole, oxadiazolidinedione, oxadiazolone, 1,2,3,5-oxathiadiazole-2-oxide, 5-oxo-4,5-dihydro-[1,3,4]oxadiazole, 5-oxo-1,2,4-thiadiazole, piperazine, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyrimidine, tetrazole, thiadiazole, thiazole, thiomorpholine, triazole and triazolone, wherein the heteroaryl radical is optionally substituted one, two or three times by —C(O)—R 15 , wherein R 15 is hydrogen or —(C 1 -C 4 )-alkyl, —(C 1 -C 4 )-alkyl, —O—R 15 , wherein R 15 is hydrogen or —(C 1 -C 4 )-alkyl, —N(R 15 )—R 16 , wherein R 15 and R 16 are, independently of each other, hydrogen or —(C 1 -C 4 )-alkyl, halogen, or a keto radical, —C(O)—R —C(O)—OR —C(O)—N(R R23 is hydrogen or —(C R24 is a heteroaryl radical selected from pyrrole, furan, thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole, tetrazole, 1,2,3,5-oxathiadiazole-2-oxide, triazolones, oxadiazolones, isoxazolones, oxadiazolidinedione, tfiazole, 3-hydroxypyrro-2,4-dione, 5-oxo-1,2,4-thiadiazole, pyridine, pyrazine, pyrimidine, indole, isoindole, indazole, phthalazine, quinoline, isoquinoline, quinoxaline, quinazoline, cinnoline, β-carboline and benzo fused cyclopenta derivatives or cyclohexa derivatives of these heteroaryl radicals, wherein the heteroaryl radical is optionally substituted, one, two or three times, independently of each other, by —(C 1 -C 5 )-alkyl, —(C 1 -C 5 )-alkoxy, halogen, nitro, amino, trifluoromethyl, hydroxyl, hydroxy—(C 1 -C 4 )-alkyl, methylenedioxy, ethylenedioxy, formyl, acetyl, cyano, hydroxycarbonyl, aminocarbonyl or —(C 1 -C 4 )-alkoxycarbonyl, or an aryl radical selected from phenyl, naphthyl, 1-naphthyl, 2-naphthyl, biphenylyl, 2-biphenylyl, 3-biphenylyl and 4-biphenylyl, anthryl and fluorenyl, wherein the aryl radical is optionally substituted, one, two or three times, independently of each other, by —(C 1 -C 5 )-alkyl, —(C 1 -C 5 )-alkoxy, halogen, nitro, amino, trifluoromethyl, hydroxyl, hydroxy—(C 1 -C 4 )-alkyl, methylenedioxy, ethylenedioxy, formyl, acetyl, cyano, hydroxycarbonyl, aminocarbonyl or —(C 1 -C 4 )-alkoxycarbonyl wherein, the pain is an acute pain selected from a group consisting of a pain following injury, a post operative pain, a pain associated with an acute attack of gout, and an acute pain following jaw-bone surgical intervention.