Patent ID: 6335451
Filing Date: 2002-01-01
Classification: A01N,A61P,C07D

Abstract:
A compound of the formula I in which the symbols have the following meaning:R1 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or â€”CaH2a-phenyl, said â€”CaH2a-phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(8)R(9); R(8) and R(9) independently of one another are H or (C1-C4)alkyl; a is zero, 1 or 2; or R1 is â€”CbH2bâ€”(C1-C9)heteroaryl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl and NR(10)R(11); R(10) and R(11) independently of one another are H or (C1-C4)alkyl; b is zero, 1 or 2; or R1 is â€”CdH2dâ€”(C3-C7)cycloalkyl; d is zero, 1 or 2; R2 and R3 independently of one another are hydrogen, F, Cl, Br, I, CF3, â€”Câ‰¡N, â€”NO2, -CH2OR17, COâ€”R6 or Oâ€”R7; R17 is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R6 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, OR30 or phenyl, said phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(31)R(32); R(31) and R(32) independently of one another are H or (C1-C4)-alkyl; R30 is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R7 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, phenyl, said phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(12)R(13); R(12) and R(13) independently of one another are H or (C1-C4)-alkyl; or R7 is (C1-C9)heteroaryl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl and NR(14)R(15); R(14) and R(15) independently of one another are H or (C1-C4)-alkyl; or R2 and R3 independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or â€”CgH2g-phenyl, said â€”CgH2g-phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(18)R(19); R(18) and R(19) independently of one another are H or (C1-C4)alkyl; g is zero, 1 or 2; or R2 and R3 independently of one another are â€”ClH2lâ€”(C1-C9)heteroaryl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl and NR(20)R(21); R(20) and R(21) independently of one another are H or (C1-C4)-alkyl; l is zero, 1 or 2; or R2 and R3 independently of one another are SOnâ€”R22; n is zero, 1 or 2; R22 is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or â€”CsH2s-phenyl, said â€”CsH2s-phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(34)R(35); R(34) and R(35) independently of one another are H or (C1-C4)-alkyl; s is zero, 1 or 2; R4 and R5 independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, â€”Câ‰¡N, â€”NO2, SOpâ€”R16, COâ€”R23 or Oâ€”R24; p is zero, 1 or 2; R16 is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, said phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(26)R(27); R(26) and R(27) independently of one another are H or (C1-C4)-alkyl; R23 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or OR25; R25 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R24 is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, said phenyl being unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl and NR(28)R(29); R(28) and R(29) independently of one another are H or (C1-C4)-alkyl; or a physiologically tolerable salt of the compound of the formula I.