Patent ID: 6028111
Filing Date: 2000-02-22
Classification: A61K,A61P,C07C,C07D,Y10S

Abstract:
A method of treating inflammatory disorders comprising administering, to a human or other animal suffering from an inflammatory disorder, an amount of a composition selected from the group consisting of N-substituted benzamides capable of forming acid addition salts and capable of inhibiting TNF-.alpha. and/or selectively inducing apoptosis and N-substituted nicotinamides capable of forming acid addition salts and capable of inhibiting TNF-.alpha. and/or selectively inducing apoptosis, and acid addition salts thereof and mixtures thereof, other than metoclopramide and benzamides with N-pyridinyl substitutions, said amount being effective to inhibit TNF-.alpha. production, thereby to inhibit an inflammatory response in said human or other animal.