Patent ID: 8129346
Filing Date: 2012-03-06
Classification: A61P,C07K

Abstract:
1. A method of inhibiting an N-terminal nucleophile hydrolase or of treating inflammation or fever, comprising administering to a subject a compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof, wherein each A is independently selected from C═O, C═S, and SO A is optionally a covalent bond when adjacent to an occurrence of Z; L is absent or is selected from C═O, C═S, and SO M is absent or is C Q is absent or is selected from O, NH, and N—C X is selected from O, NH, and N—C Y is absent or is selected from 0, NH, N—C each Z is independently selected from 0, S, NH, and N—C Z is optionally a covalent bond when adjacent to an occurrence of A; R R R R R R R each R R provided that when R in any occurrence of the sequence ZAZ, at least one member of the sequence must be other than a covalent bond.