Patent ID: 6486173
Filing Date: 2002-11-26
Classification: C07D

Abstract:
A compound of formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein:R1 is selected from a C6-10 carbocyclic aromatic residue substituted with 1-3 R1a, and a 5-10 membered aromatic heterocyclic system containing from 1-4 heteroatoms selected from N, O and S, substituted with 0-2 R1a; R1a is independently selected at each occurrence from halo, â€”NO2, â€”CN, â€”CF3 and â€”CF2CF3; X is selected from â€”S(O)2â€”, â€”S(O)â€”, â€”Sâ€”; R4 is selected from hydrogen and C1-6 alkyl; R4a is taken together with R1 to form a 5 or 6-membered fused heterocyclic ring containing 1-2 heteroatoms selected from O and N, substituted with 1 or 2 carbonyl groups; Y is C1-3 alkylene; A is selected from a 5 or 6 membered saturated, partially saturated or unsaturated ring which contains from 0-1 heteroatoms selected from N, O and S, substituted with 0-3 R5, napthyl substituted with 0-3 R5, and napthyl fused with ring B substituted with 0-3 R5; R5 is selected from C1-5 alkyl, halo and â€”OCH3; n is selected from 1, 2, and 3.