Patent ID: 8828719
Filing Date: 2014-09-09
Classification: C07K,C12N,C12P,Y02P

Abstract:
1. An in vitro recombinant host cell, wherein the cell is modified to comprise (a) an exogenous polynucleotide sequence encoding Endoplasmic Reticulum Oxidoreductin 1 (Ero1) or a variant thereof which retains at least 80% of the activity of an endogenous Ero1, and (b) an exogenous polynucleotide sequence encoding X-box binding protein 1 (XBP1) or a variant thereof which retains at least 80% of the activity of the endogenous XBP1, wherein said modified host cell has increased expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell of the same type.