Patent ID: 6232326
Filing Date: 2001-05-15
Classification: A61K

Abstract:
A method for ameliorating positive and negative symptoms of schizophrenia and tardive dyskinesia comprising administering to a patient exhibiting such symptoms an effective amount of a compound selected from neurotoxic substrates for monoamine oxidase A or B (MAO- A or B) having the following formula: ##STR5##wherein R.sub.1 is H methyl, CH.sub.2 CCH, phenyl or benzyl;A is substituted or unsubstituted phenyl, a substituted or unsubstituted, saturated or unsaturated five or six-membered heterocyclic ring having S or O as a ring member, a substituted unsubstituted, saturated unsaturated five- six-membered cycloalkyl ring or N(CH.sub.3).sub.2 ;n=1 or 0;B is CH.sub.2 or O;pyridinium ions thereof; andpharmaceutically acceptable salts of the foregoing.