Patent ID: 7419804
Filing Date: 2008-09-02
Classification: A61K,A61P,C12N

Abstract:
1. An isolated molecule comprising a DNA sequence encoding a polypeptide which is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4, which polypeptide has the amino acid sequence of: (a) a G1 protein isoform whose sequence is that of SEQ ID NO:4; (b) an analog of (a) which differs from the sequence of (a) by no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion and/or insertion of a single amino acid, which analog is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4; or (c) a derivative of (a) or (b) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4.