Patent ID: 6448294
Filing Date: 2002-09-10
Classification: C07C,Y10S

Abstract:
A method of treating symptoms linked to menopause in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound of the formula wherein X is R1 and R2 are individually hydrogen or alkyl of 1 to 4 carbon atoms, R3 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R4 is in the meta or para position and is selected from the group consisting of hydrogen, halogen, â€”OH, alkyl and alkenyl and alkynyl of up to 4 carbon atoms, alkoxy and alkylthio of 1 to 4 carbon atoms, optionally RA and RB are individually hydrogen or alkyl of 1 to 4 carbon atoms, or taken together with the nitrogen form a saturated 5 to 6 member ring heterocycle with an optional second heterocycle selected from the group consisting of oxygen, nitrogen and sulfur, n is an integer from 2 to 7, R5 is hydrogen or halogen, R6 and R7 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 4 carbon atoms and phenyl optionally substituted in the meta or para position with R4 and their addition salts with non-toxic, pharmaceutically acceptable bases and acids, with the provisos that X is not (A) , when R1, R2 and R3 are hydrogen and R4 is â€”OH and X is not (B) when R5 and R6 are hydrogen and R7 is alkyl of 1 to 4 carbon atoms sufficient to treat said symptoms.