Patent ID: 6255321
Filing Date: 2001-07-03
Classification: A61P,C07D

Abstract:
A 2-sulfamoylbenzoic acid derivative represented by general formula (I): ##STR631##wherein R1 and R2 which may be the same or different, are hydrogen atoms, C.sub.3-8 cycloalkyl groups, optionally substituted C.sub.1-6 alkyl groups, optionally substituted aryl groups or form, together with the ring ##STR632##a condensed ring represented by formula ##STR633##which may be substituted with an optionally substituted C.sub.1-6 alkyl group, an amino group, a cyano group, a nitro group, a hydroxyl group, a halogen atom or a C.sub.1-5 alkoxy group, X is an oxygen atom, a nitrogen atom, a sulfur atom or --CH.dbd.CH--, R3 is an optionally substituted phenylsulfonylamino group, an optionally substituted phenylsulfonyl group or an optionally substituted phenylsulfoxide group, R4 is a hydrogen atom or an ester residue, n is an integer of from 2 to 6, A is --O--B--, --B--O--, --S--B--, --B--S-- or --B--, and B is a C.sub.1-6 alkylene group or a C.sub.2-5 alkenylene group, provided that the cases wherein R1 is a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group or a phenyl group, R2 is a hydrogen atom, A is a vinylene group, and X is a sulfur atom are excluded) or a pharmaceutically acceptable salt, hydrate or solvate thereof.