Patent ID: 6576435
Filing Date: 2003-06-10
Classification: C12Q,G01N

Abstract:
A method for predicting a refractory response in a subject diagnosed as having periodontitis, wherein the refractory response is defined as loss of tooth attachment in the subject after scaling and root planing, surgery, and treatment with tetracycline, the method comprising:providing a blood or serum sample from a subject diagnosed as having periodontitis; measuring an actinomyces antibody concentration in the blood or serum sample; measuring a streptococcal antibody concentration in the blood or serum sample; measuring a lysine decarboxylase antibody concentration in the blood or serum sample; and calculating a refractory response score predictive of whether the subject is likely to have a refractory response, the refractory response score obtained by combining the lysine decarboxylase antibody concentration, the actinomyces antibody concentration and the streptococcal antibody concentration.