Patent ID: 8017763
Filing Date: 2011-09-13
Classification: A61K,A61P,C07F,C12N

Abstract:
1. An isolated oligonucleotide agent, comprising a nucleotide sequence consisting of from 12 to 23 nucleotides in length sufficiently complementary to a microRNA target sequence, wherein the nucleotide sequence of the oligonucleotide agent differs by no more than 1 or 2 nucleotides from full complementary to the microRNA target sequence, wherein the microRNA target sequence has the nucleobase sequence of miR-21, and wherein the oligonucleotide has the structure (I): wherein: each Q is independently a 2′-modified nucleoside; x, z  where one of A and B is S while the other is O; y is n =6−17; L is