Patent ID: 6830756
Filing Date: 2004-12-14
Classification: A61B,A61K,A61L,A61P

Abstract:
A method for sealing a vascular puncture site comprising the steps ofmixing a first component, a second component, and a buffer material, the first component including an electrophilic polymer material comprising poly(ethylene glycol) having a molecular weight between 9000 and 12,000 and having a functionality of at least three, the second component including a nucleophilic material comprising human serum albumin at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier, and the buffer material including tris-hydroxymethylaminomethane having a pH within the reaction pH range, and applying the mixture to seal a vascular puncture site.