Patent ID: 7091348
Filing Date: 2006-08-15
Classification: A61P,C09B,G01N

Abstract:
1. A fluorescence energy transfer dye having the Formula I: where: L1 is a link that is a chemical bond for attachment to a probe or target, for attachment to a solid support, or is absent; L2 is a link that is a chemical bond for attachment to a probe or target, for attachment to a solid support, or is absent; FETL is a fluorescence energy transfer linker that is a symmetric, rigid or sterically hindered, divalent moiety joined to D1 and D2 via an amine, carbonyl, activated carboxylic acid ester, disulfide, thiol or thiol ester; D1 is a donor dye represented by the formula: where: X is O or C(R*R**), where R* and R** are independently lower alkyl or —CH R R R R R R R R R Z is a group of the formula: -Z*-Z D2 is an acceptor/reporter dye represented by formula D1 or by a formula of the group: where: at least one of R n is zero, 1, 2 or 3; R R R R Y is —O— or —N(Y provided that at least one of R 3 to R 8 is Z where Z* is optionally substituted aryl or optionally substituted heteroaryl.