Patent ID: 6054556
Filing Date: 2000-04-25
Classification: C07K,Y10S

Abstract:
A cyclic peptide selected from the group consisting of:Ac-Nle-c[Asp-Trp-D-Nal(2')-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 1);Ac-Nle-c[Asp-His(1-Me)-D-Nal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 2);Ac-Nle-c[Asp-His(3-Me)-D-Nal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 3);Ac-Nle-c[Asp-Tal(4')-D-Nal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 4);Ac-Nle-c[Asp-His(1-Me)-D-Nal(2')-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 5);Ac-Nle-c[Asp-His(3-Me)-D-Nal(2')-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 6);Ac-Nle-c[Asp-Tal(4')-D-Nal(2')-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 7);Ac-Nle-c[Asp-His-(2R,3R)-.beta.-MeNal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 8);Ac-Nle-c[Asp-His-(2R,3S)-.beta.-MeNal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 9);Ac-Nle-c[Asp-Trp-D-Phe-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 10);Ac-Nle-c[Asp-His-D-Nal(2')-Arg-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 11);Ac-Nle-c[Asp-His-Nal(2')-Arg-Trp-Lys]-NH.sub.2 (SEQ ID NO: 12);Ac-Nle-c[Asp-His-D-Nal(2')-Nle-Trp-Lys]-NH.sub.2 (SEQ ID NO: 13);Ac-Nle-c[Asp-Trp-D-Nal(2')-Nle-Trp-Lys]-NH.sub.2 (SEQ ID NO: 14);Ac-Nle-c[Asp-His-D-Phe-Nal(2')-Trp-Lys]-NH.sub.2 (SEQ ID NO: 15); andAc-Nle-c[Asp-His-D-Nal(2')-Arg-D-Nal(2')-Lys]-NH.sub.2 (SEQ ID NO: 16).