Patent ID: 7157433
Filing Date: 2007-01-02
Classification: A61P,C07J

Abstract:
1. A compound of the formula I: wherein M represents a group of Formula II:  wherein: (i) Z and W independently are: >C═O, >CH (ii) U and Y independently are hydrogen, halogen, alkyl, or hydroxyalkyl; (iii) R (iv) S  wherein (v) S  wherein: (vi) R (vii) A is hydrogen or methyl; (viii) B is methyl or epoxy; (ix) E is hydrogen or halogen; (x) R (xi) R (xii) R (xiii) R R wherein M has a linkage site through which it is linked to V via linking group L; provided that the linkage site is at one or more of the following: V is chosen from the group consisting of (i) an anti-inflammatory steroid subunit of the Formula X: wherein R R R R R (ii) a non-steroidal anti-inflammatory subunit derived from the NSAIDs selected from: aceclofenac, acemetacin, acetaminophen, acetaminosalol, acetyl-salicylic acid, acetyl-salicylic-2-amino-4-picoline-acid, 5-aminoacetylsalicylic acid, alclofenac, aminoprofen, amfenac, ampyrone, ampiroxicam, anileridine, bendazac, benoxaprofen, bermoprofen, α-bisabolol, bromfenac, 5-bromosalicylic acid acetate, bromosaligenin, bucloxic acid, butibufen, carprofen, celexocib, chromoglycate, cinmetacin, clindanac, clopirac, sodium diclofenac, diflunisal, ditazol, droxicam, enfenamic acid, etodolac, etofenamate, felbinac, fenbufen, fenclozic acid, fendosal, fenoprofen, fentiazac, fepradinol, flufenac, flufenamic acid, flunixin, flunoxaprofen, flurbiprofen, glutametacin, glycol salicylate, ibufenac, ibuprofen, ibuproxam, indomethacin, indoprofen, isofezolac, isoxepac, isoxicam, ketoprofen, ketorolac, lornoxicam, loxoprofen, meclofenamic acid, mefenamic acid, meloxicam, mesalamine, metiazinic acid, mofezolac, montelukast, nabumetone, naproxen, niflumic acid, nimesulide, olsalazine, oxaceprol, oxaprozin, oxyphenbutazone, paracetamol, parsalmide, perisoxal, phenyl-acethyl-salicylate, phenylbutazone, phenylsalicylate, pyrazolac, piroxicam, pirprofen, pranoprofen, protizinic acid, reserveratol, salacetamide, salicylamide, salicylamide-O-acetyl acid, salicylsulphuric acid, salicin, salicylamide, salsalate, sulindac, suprofen, suxibutazone, tamoxifen, tenoxicam, tiaprofenic acid, tiaramide, ticlopridine, tinoridine, tolfenamic acid, tolmetin, tropesin, xenbucin, ximoprofen, zaltoprofen, zomepirac, tomoxiprol, zafirlukast and cyclosporine; (iii) an antineoplastic subunit derived from the antineoplastic compounds selected from bicaluatnide, camptothecin, estramustine phosphate, flutamide, mechlorethamine, thiotepa, ifosfamide, hydroxyurea, bleomycin, paclitaxel, lomustine, irinotecan, methotrexate, vinorelbine, anastrazole, floxuridine, melphalan, vincristine, vinblastine, mitomycin, nandrolone, goserelin, leuprolide, triptorelin, aminogluthetemide, mitotane, cisplatine, chlorambucil, pentostatin, cladribine, busulfan, etoposide, mitoxantrone, idarubicin, cyclophosphamide, mercaptopurine, thioguanine, cytarbine, cyclophosphamide, doxorubicin, daunoribicin, teniposide tamoxifen, taxotere and topotecan; and (iv) an antiviral subunit derived from the anti-viral compounds selecting from aciclovir, famciclovir, ganciclovir, cidofovir, lamivudine, ritonavir, indinavir, nevirapine, zidovudine, didanosine, stavudine, abacavir, amprenavir, ribavirin and adamantane; provided that when V is a steroid or non-steroidal anti-inflammatory subunit, L is a peptide; and L is a linker molecule to which each of M and V are covalently linked; or a pharmaceutically acceptable salt or solvate thereof or an individual diastereoisomer thereof.