Patent ID: 7767398
Filing Date: 2010-08-03
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method for diagnosing an affective disorder or a susceptibility to an affective disorder in an individual comprising the steps of (a) determining in a sample obtained from an individual whether the ATP-gated ion channel purinergic receptor P2X7 gene sequence or encoded protein thereof comprises a mutation in comparison to the wild-type ATP-gated ion channel purinergic receptor P2X7 sequence, wherein said mutation is a nucleotide replacement or deletion in exon 13, nucleotide A, at position 54480 in the nucleotide sequence of the wild-type ATP-gated ion channel P2X7R as depicted in SEQ ID NO: 1, and the presence of said mutation indicates that the individual suffers from or is susceptible to an affective disorder; and (b) detecting an affective disorder or a susceptibility to an affective disorder.