Patent ID: 6211174
Filing Date: 2001-04-03
Classification: A61K,C07D

Abstract:
A compound which is selected from the group consisting of:2-Amino-2-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(methylamino)carbonyl ]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3( R)-yl]propanamide;3-Amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(methylamino)carbonyl ]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3( R)-yl]butanamide;3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[( methylamino)carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-nap htho[2,1-b]azepin-3(R)-yl]butanamide;3-[2(S),3-Dihydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'- [[[(methylamino)carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]-methyl]-4-oxo-1 H-naphtho[2,1-b]azepin-3(R)-yl]butanamide;2-Amino-2-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[(aminocarbonyl)amino]m ethyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R)-yl]pr opanamide;3-Amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[(aminocarbonyl)amino]m ethyl][1,1+-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R)-yl]bu tanamide;3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[(( aminocarbonyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2, 1-b]azepin-3(R)-yl]butanamide;3-[2(S),3-Dihydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'- [[(aminocarbonyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho [2,1-b]azepin-3(R)-yl]butanamide;2-Amino-2-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(ethylamino)carbonyl] amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R )-yl]propanamide;3-Amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(ethylamino)carbonyl] amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R )-yl]butanamide;3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[( ethylamino)carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naph tho[2,1-b]azepin-3(R)-yl]butanamide;3-[2(S),3-Dihydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'- [[[(ethylamino)carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H- naphtho[2,1-b]azepin-3(R)-yl]butanamide;2-Amino-2-methyl-N-[3(R -2,3,4,5-tetrahydro-5-[[2'-[[[[(hydroxyethyl)amino]carbonyl]amino]methyl][ 1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R)-yl]propanami de;3-Amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[[(hydroxyethyl)amino] carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]a zepin-3(R)-yl]butanamide;3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[[ (hydroxyethyl)amino]carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]-methyl]-4-o xo-1H-naphtho[2,1-b]azepin-3(R)-yl]butanamide;3-[2(S),3-Dihydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'- [[[[(hydroxyethyl)amino]carbonyl]amino]-methyl][1,1'-biphenyl]-4-yl]methyl] -4-oxo-1H-naphtho[2,1-b]azepin-3(R)-yl]butanamide;2-Amino-2-methyl-N-[3(S)-2,3,4,5-tetrahydro-1-[[2'-[2-[[(methylamino)carbon yl]amino]prop-2-yl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azep in-3(R)-yl]propanamide;2-Amino-2-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[1-[[(methylamino)carbon yl]amino]ethyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3 (R)-yl]propanamide;2-Amino-2-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(methylamino)carbonyl ]oxy]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R) -yl]propanamide;3-Amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[(methylamino)carbonyl ]oxy]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-naphtho[2,1-b]azepin-3(R) -yl]butanamide;3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'-[[[( methylamino)carbonyl]oxy]methyl][1,1'-biphenyl]-4-yl]-methyl]-4-oxo-1H-naph tho[2,1-b]azepin-3(R)-yl]butanamide;3-[2(S),3-Dihydroxypropyl]amino-3-methyl-N-[3(R)-2,3,4,5-tetrahydro-5-[[2'- [[[(methylamino)carbonyl]oxy]methyl][1,1'-biphenyl]-4-yl]methyl]-4-oxo-1H-n aphtho[2,1-b]azepin-3(R)-yl]butanamide;and pharmaceutically acceptable salts thereof.