Patent ID: 7435427
Filing Date: 2008-10-14
Classification: A61K,A61P

Abstract:
1. An oral pharmaceutical composition of isotretinoin contained in a pharmaceutically acceptable capsule which comprises a semi-solid suspension containing at least two lipidic excipients, at least in an amount of about 20 to 80% of one being hydrophilic having a HLB value equal to or greater than 10 selected from the group consisting of glyceroyl macrogolglycerides, polyethylene glycol esters, and mixtures thereof; the other in an amount of about 5 to 70% and being an oily vehicle selected from the group consisting of vegetable oils, medium chain triglycerides, fatty acid esters, glycerol oleate and mixtures thereof; and an amount of about 1 to 10% of at least one additional surfactant.