Patent ID: 6096761
Filing Date: 2000-08-01
Classification: A01N,C07D

Abstract:
A compound of formula (I) ##STR153## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid or base addition salt thereof, whereinR.sup.1 is C.sub.1-6 alkyloxy, C.sub.2-6 alkenyloxy or C.sub.2-6 alkynyloxy;R.sup.2 is hydrogen or C.sub.1-6 alkyloxy,or taken together R.sup.1 and R.sup.2 may form a bivalent radical of formul a--O--CH.sub.2 --O-- (a-1),--O--CH.sub.2 --CH.sub.2 -- (a-2),--O--CH.sub.2 --CH.sub.2 --O-- (a-3),--O--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-4),--O--CH.sub.2 --CH.sub.2 --CH.sub.2 --O-- (a-5),--O--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-6),wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C.sub.1-6 alkyl,R.sup.3 is hydrogen or halo;R.sup.4 is hydrogen or C.sub.1-6 alkyl;L is C.sub.3-6 cycloalkyl, C.sub.5-6 cycloalkanone, C.sub.2-6 alkenyl optionally substituted with aryl, or L is a radical of formula--Alk--R.sup.5 (b- 1),--Alk--X--R.sup.6 (b- 2),--Alk--Y--C(.dbd.O)--R.sup.8 (b- 3),or--Alk--Y--C(.dbd.O)--NR.sup.10 R.sup.11 (b- 4),wherein each Alk is C.sub.1-12 alkanediyl; andR.sup.5 is hydrogen, cyano, C.sub.1-6 alkylsulfonylamino, C.sub.3-6 cycloalkyl, C.sub.5-6 cycloalkanone, aryl, di(aryl)methyl or Het.sup.1 ;R.sup.6 is hydrogen, C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl or Het.sup.2 ;X is O, S, SO.sub.2 or NR.sup.7 ; said R.sup.7 being hydrogen, C.sub.1-6 alkyl or aryl;R.sup.8 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl, arylC.sub.1-6 alkyl, di(aryl)methyl, C.sub.1-6 alkyloxy or hydroxy;Y is NR.sup.9 or a direct bond; said R.sup.9 being hydrogen, C.sub.1-6 alkyl or aryl;R.sup.10 and R.sup.11 each independently are hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl or arylC.sub.1-6 alkyl, or R.sup.10 and R.sup.11 combined with the nitrogen atom bearing R.sup.10 and R.sup.11 may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C.sub.1-6 alkyl, amino or mono or di(C.sub.1-6 alkyl)amino, or said R.sup.10 and R.sup.11 combined with the nitrogen bearing R.sup.10 and R.sup.11 may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C.sub.1-6 alkyl;each aryl being unsubstituted phenyl or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino-sulfonyl, C.sub.1-6 alkylcarbonyl, nitro, trifluoromethyl, amino or aminocarbonyl; and Het.sup.1 and Het.sup.2 each independently are selected from furanyl; furanyl substituted with C.sub.1-6 alkyl or halo; tetrahydrofuranyl; a tetrahydrofuranyl substituted with C.sub.1-6 alkyl; a dioxolanyl; a dioxolanyl substituted with C.sub.1-6 alkyl, a dioxane; a dioxane substituted with C.sub.1-6 alkyl; tetrahydropyranyl; a tetrahydropyranyl substituted with C.sub.1-6 alkyl; pyrrolidinyl; pyrrolidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, or C.sub.1-6 alkyl; pyridinyl; pyridinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C.sub.1-6 alkyl; pyrimidinyl; pyrimidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino and mono and di(C.sub.1-6 alkyl)amino; pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from hydroxy, C.sub.1-6 alkyloxy, C.sub.1-6 alkyl or halo; pyrazinyl; pyrazinyl substituted with one ore two substituents each independently selected from halo, hydroxy, cyano, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- and di(C.sub.1-6 alkyl)amino and C.sub.1-6 alkyloxycarbonyl;Het.sup.1 can also be a radical of formula ##STR154## Het.sup.1 and Het.sup.2 each independently can also be selected from the radicals of formula ##STR155## R.sup.12 and R.sup.13 each independently are hydrogen or C.sub.1-4 alkyl.