Patent ID: 8119145
Filing Date: 2012-02-21
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for producing viral-like particles (VLPs), the method comprising: a) transforming an isolated host cell with an expression vector comprising a recombinant polynucleotide, wherein the polynucleotide comprises a nucleotide sequence selected from the group consisting of: (i) a polynucleotide comprising a sequence with at least 98% sequence identity to the sequence of SEQ ID NO:1; and (ii) a polynucleotide comprising the sequence of SEQ ID NO:2, wherein the polynucleotide is operably linked to control elements that direct the expression of said nucleotide sequence in a yeast host cell, and further wherein the polynucleotide contains less than an entire Norovirus genome; and b) culturing the transformed host cell under conditions whereby capsid proteins are expressed and assembled into VLPs.