Patent ID: 6541463
Filing Date: 2003-04-01
Classification: A61K,A61P,C07J

Abstract:
An inhibitor of type 5 17&bgr;-hydroxysteroid dehydrogenase having the molecular structure: wherein n is an integer from 1-2; wherein the dotted lines are optional pi bonds; wherein X and Y are independently selected from the group consisting of âˆ’H, (C1-C3)alkyl, (C2-C3) alkenyl, and methoxycarbonyl; wherein Z is selected from the group consisting of â€”H and (C1-C3)alkyl; wherein R3 is selected from the group consisting of hydrogen, acyl, carboxyl, alkoxycarbonyl, substituted or unsubstituted carboxamide, cyano, alkoxy, alkoxyalkoxy, alkythioalkoxy, acyloxy; hydroxy, halo, â€”Oâ€”SO2Ra (Ra being selected from the group consisting of C1-C6 alkyl and C6-C10 aryl), and together with R2 is: â€”CH&boxH;Nâ€”Oâ€”; wherein R2 is selected from the group consisting of hydrogen, amido, acyloxy, carboxyl, carboxamide, alkoxycarbonyl, cyano, halo, nitro, C1-C8 alkyl, and CF3 and together with R3 is: â€”CH&boxH;Nâ€”Oâ€”; wherein R4 is hydrogen or halo; wherein R6 is selected from the group consisting of hydrogen and oxo; wherein R9 is âˆ’H or âˆ’OH. provided that X, Y, and Z are not all hydrogen; and R3 is not hydroxyl or alkoxy when R2, R4, R6 and R9 are all hydrogen atoms.