Patent ID: 6270799
Filing Date: 2001-08-07
Classification: A61K,A61P

Abstract:
A diffusion-controlled pellet drug formulation having controlled release of an active compound, comprising:(a) 10-50% by weight of neutral pellet;(b) 10-85% by weight of a first coat covering said neutral pellet, said first coat comprising a mixture that is 70-99.5% by weight of the active compound, which is selected from 1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3. 0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolonecarboxylic acid and pharmaceutically tolerable salts and/or hydrates thereof, and 0.5%-30% by weight of a binder; and(c) 5-40% by weight of a diffusion coat covering said first coat, said diffusion coat comprising 40-90% by weight of a film former, 0-50% by weight of a pore former and 5-50% by weight of a plasticizer;wherein said drug formulation has an average release of active compound of between 80% in 2 hours and 80% in 16 hours and an initial release that is less than 60% of the active compound in the first hour of release.