Patent ID: 6013436
Filing Date: 2000-01-11
Classification: C07K,C12Q

Abstract:
A method for testing a plurality of patients for a disease-associated mutation in the VHL tumor suppressor gene, comprising the steps of:a) selecting a hierarchical system of assays comprising at least a first and final assay, said first assay being selected to provide a test for the existence of the disease-associated mutation with less than 1% false results indicating the presence of a disease associated mutation and said final assay being selected to provide a test for the existence of the disease associated mutation with less than 1% false results indicating the presence of a disease associated mutation and less than 1% false results indicating the absence of the disease associated mutation;b) analyzing a body sample from each of the plurality of patients using the first assay; and, if the result of the first assay is negative for the presence of a disease-associated mutation;c) analyzing the body sample using the final assay.