Patent ID: 7816385
Filing Date: 2010-10-19
Classification: C07C,C07D

Abstract:
1. A compound selected from the group consisting of: (S,S)-2-Ethoxy-3-{4-[3-(4′-{3-[4-(2-ethoxy-2-isopropoxycarbonyl-ethyl)-phenoxy]-propyl}-2,2′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-propionic acid; (S,S)-3-{4-[3-(4′-{3-[4-(2-Carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2′-bis -trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid; (S,S)-2-Ethoxy-3-{4-[3-(4′-{3-[4-(2-ethoxy-2-isopropoxycarbonyl-ethyl)-phenoxy]-propyl}-3,3′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-propionic acid; (S,S)-3-{4-[3-(4′-{3-[4-(2-Carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-3,3′-bis -trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid; (S,S)-3-{3-Bromo-4-[3-(4′-{3-[2-bromo-4-(2-ethoxy-2-isopropoxycarbonyl-ethyl) -phenoxy]-propyl}-2,2′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy -propionic acid; (S,S) -3-{3-Bromo-4-[3-(4′-{3-[2-bromo-4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid; (S,S)-3-{3-Bromo-4-[3-(4′-{3-[2-bromo-4-(2-ethoxy-2-isopropoxycarbonyl-ethyl)-phenoxy]-propyl}-3,3′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy -propionic acid; (S,S)-3-{3-Bromo-4-[3-(4′-{3-[2-bromo-4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-3,3′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid; [4-(3-{4′-[3-(4-Methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2 ,2′-bis -trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid; [4-(3-{4′-[3-(4-Methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-3,3′-bis -trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid; [4-(3-{4′-[3-(4-Carboxymethoxy-3-methyl-phenylsulfanyl)-propyl]-3,3′-bis -trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid; (4-{2-[2-(3-{4-[2-(4-Methoxycarbonyl methoxy-3-methyl-phenylsulfanyl)-ethyl]-5-methyl-oxazol-2-yl}-phenyl)-5-methyl-oxazol-4-yl]-ethylsulfanyl}-2-methyl-phenoxy) -acetic acid; (4-{2-[2-(3-{4-[2-(4-Carboxymethoxy-3-methyl -phenylsulfanyl)-ethyl]-5-methyl -oxazol-2-yl}-phenyl)-5-methyl-oxazol-4-yl]-ethylsulfanyl}-2-methyl-phenoxy)-acetic acid; (S,S)-2-Ethoxy-3-[4-(2-{2-[4′-(4-{2-[4-(2-ethoxy-2-isopropoxycarbonyl-ethyl) -phenoxy]-ethyl}-5-methyl-oxazol-2-yl)-biphenyl-4-yl]-5-methyl-oxazol-4-yl}-ethoxy)-phenyl]-propionic acid; (S,S)-3-[4-(2-{2-[4′-(4-{2-[4-(2-Carboxy-2-ethoxy-ethyl)-phenoxy]-ethyl}-5-methyl-oxazol-2-yl)-biphenyl-4-yl]-5-methyl-oxazol-4-yl}-ethoxy)-phenyl]-2-ethoxy -propionic acid; (S,S)-2-Ethoxy-3-[4-(2-{2-[3-(4-{2-[4-(2-ethoxy-2-isopropoxycarbonyl-ethyl)-phenoxy]-ethyl}-5-methyl-oxazol-2-yl)-phenyl]-5-methyl -oxazol-4-yl}-ethoxy) -phenyl]-propionic acid; and (S,S)- 3-[4-(2-{2-[3-(4-{2-[4-(2-Carboxy-2-ethoxy-ethyl)-phenoxy]-ethyl}-5-methyl-oxazol-2-yl)-phenyl]-5-methyl-oxazol-4-yl}-ethoxy)-phenyl]-2-ethoxy-propionic acid; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, racemic mixture, or any tautomeric forms.