Patent ID: 7763649
Filing Date: 2010-07-27
Classification: C07C,C07D,C07F,C07H

Abstract:
1. A method of treating cardiac arrhythmia in a subject comprising administering to the subject who would benefit from such treatment an effective amount of a pharmaceutically acceptable formulation to increase connexin 43 expression in at least the a portion of the myocardium of the subject, said pharmaceutically acceptable formulation comprising a synthetic carotenoid analog or derivative; wherein the synthetic carotenoid analog or derivative has the structure wherein y is from 5 to 12; wherein each R where each R wherein each substituent —W is independently —OX —O(CO)R, wherein each —X is independently  -alkyl-NR wherein each R wherein each R wherein each R wherein each —R is independently -alkyl-NR wherein R' is -alkyl-O, alkyl, or aryl; wherein R and wherein R  or aryl.