Patent ID: 7118876
Filing Date: 2006-10-10
Classification: C12Q,G01N

Abstract:
1. A method of diagnosing an abnormal prostate condition in an animal, wherein the abnormal prostate condition is adenocarcinoma, benign prostatic hyperplasia (BPH), or prostatic intraepithelial neoplasia (PIN), the method comprising the steps of: a. assaying a prostate tissue sample from the animal to determine how much Breast Tumor Kinase (BRK) protein is located in nuclei of epithelial cells within the animal prostate tissue; b. assaying a normal prostate tissue sample from the animal to determine how much BRK protein is located in the nuclei of epithelial cell within the normal prostate tissue; and c. comparing the amount of BRK protein in the nuclei of epithelial cells from the prostate tissue sample in step (a) with the amount of BRK protein in the nuclei of epithelial cells from the normal prostate tissue sample in step (b), wherein an abnormal prostate having adenocarcinoma, benign prostatic hyperplasia (BPH), or prostatic intraepithelial neoplasia (PIN) is identified if the amount of BRK protein in the nuclei of epithelial cells from step (a) is less than the amount of BRK protein in the nuclei of epithelial cells from step (b).