Patent ID: 9156756
Filing Date: 2015-10-13
Classification: C07C,C07D,C07F

Abstract:
1. A process for the preparation of an amino alcohol of formula: wherein R R the process comprising the steps of: slowly adding 2,2,2-trifluoroethanol and achiral additive to a base to form a reaction mass, wherein the chiral additive is selected from the group consisting of (1R,2S)-pyrrolidinyl norephidrine, its enantiomers, and diastereomers, and wherein the base is selected from the group consisting of metal hydrides, metal alkoxides and metal hydroxides in an organic solvent; treating the reaction mass with a metal halide to obtain a chiral metal complex, wherein the metal halide is selected from the group consisting of zinc halide and copper halide; adding an organometallic reagent of formula R stirring the suspension to obtain a chiral organometal complex; and mixing 4-chloro-2-trifluoroacetylaniline with the chiral organometal complex to produce the desired chiral amino alcohol.