Patent ID: 7196191
Filing Date: 2007-03-27
Classification: C07B,C07C

Abstract:
1. A method of oxidizing a hydrocarbon according to the chemical structure: comprising reacting the hydrocarbon in an anhydrous solvent with a chromium [VI] oxidant and a co-oxidant at a reaction temperature of between about −50° C. to about 0° C., thereby catalytically and chemospecifically oxidizing the hydrocarbon: (i) substantially stereospecifically at a tertiary carbon to form a hemiacetal according to the structure: wherein the chromium [VI] oxidant is selected from the group consisting of CrO3, chromoyl diacetate, chromoyl chloride, chromoyl bistrifluoroacetate, chromoyl bistriflate, and chromoyl bis t-butylester, the co-oxidant is selected from the group consisting of periodic acid, tetrabutylammonium periodate, hydrogen peroxide, t-butyl hydroperoxide, diacyl peroxides, TMSOOTMS, peroxydisulfate and persulfate, and the solvent is selected from the group consisting of acetic acid, acetonitrile, methylene chloride and mixtures, thereof.