Patent ID: 7625567
Filing Date: 2009-12-01
Classification: A61K,A61P,Y02A

Abstract:
1. A method of enhancing the humoral immune response of a patient relative to the normal humoral immune response, comprising the steps of: growing cells containing a tumor antigen, a bacterial protein, or a viral protein under conditions wherein an aspartic acid residue or an asparigine residue in said tumor antigen, said bacterial protein, or said viral protein is converted to an isoaspartic acid residue to produce an isoaspartic acid-containing tumor antigen, an isoaspartic acid-containing bacterial protein, or an isoaspartic acid-containing viral protein, said conditions comprising exposing said cells to 15-30 μM adenosine dialdehyde at approximately 25-40° C. for 1-5 days; optionally isolating said isoaspartic acid-containing tumor antigen, an isoaspartic acid-containing bacterial protein, or an isoaspartic acid-containing viral protein; and administering said cells or said isolated isoaspartic acid-containing tumor antigen, an isoaspartic acid-containing bacterial protein, or an isoaspartic acid-containing viral protein to said patient to enhance the humoral immune response of said patient.