Patent ID: 9132087
Filing Date: 2015-09-15
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical intratympanic formulation comprising: a multiparticulate immunomodulating agent, or pharmaceutically acceptable salt thereof wherein the immunomodulating agent is in the form of non-coated micronized particles; and a polyoxyethylene-polyoxypropylene copolymer in an amount sufficient to provide a viscosity of between about 750 and 1,000,000 centipoise, or allow for injection through the tympanic membrane with a 18-30 gauge needle; the pharmaceutical intratympanic formulation having an osmolarity of about 100 mOsm/L to about 500 mOsm/L; wherein a single administration of the pharmaceutical intratympanic formulation provides sustained release of the immunomodulating agent into the inner ear through the round window membrane for a period of at least 5 days.