Patent ID: 6613801
Filing Date: 2003-09-02
Classification: A61K,A61P,C07C,C07D,Y10S

Abstract:
A compound of Formula (I): whereinR1 and R2 are independently selected from a) â€”H; b) â€”C1-6 alkyl; c) -aryl; d) â€”C1-6 alkylaryl; e) â€”C(O)â€”Oâ€”C1-6 alkyl; f) â€”C(O)â€”Oâ€”C1-6 alkylaryl; h) â€”C(O)â€”NHâ€”C1-6 alkylaryl; i) â€”SO2â€”C1-6 alkyl; j) â€”SO2â€”C1-6 alkylaryl; k) â€”SO2-aryl; l) â€”SO2â€”NHâ€”C1-6 alkyl; m) â€”SO2â€”NHâ€”C1-6 alkylaryl; n) o) â€”C(O)â€”C1-6 alkyl; and p) â€”C(O)â€”C1-6 alkylaryl; R3 is selected from (a) -aryl; and (b) â€”C1-3 alkylaryl, wherein aryl is substituted by C1-6 alkyl, C1-6 alkoxy, C1-6 alkylaryl, or C1-6 alkoxyaryl; R4 is selected from R5 and R6 are independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkylaryl, and aryl; and wherein the aryl and/or alkyl group(s) in R1, R2, R4, R5, R6, R7, R8, R9, R10, R18, R19, and R20 may be optionally substituted 1-4 times with a substituent group, wherein said substituent group(s) or the term substituted refers to groups selected from the group consisting of: a) â€”H; b) â€”Yâ€”C1-6 alkyl; â€”Y-aryl; â€”Yâ€”C1-6 alkylaryl; â€”Yâ€”C1-6-alkyl-NR7R8; and â€”Yâ€”C1-6-alkyl-Wâ€”R20; and c) halogen, hydroxyl, cyano, carbamoyl, or carboxyl; and whereinY and W are independently selected from the group consisting of â€”CH2â€”, â€”Oâ€”, â€”N(H), â€”Sâ€”, SO2â€”, â€”CON(H)â€”, â€”NHC(O)â€”, â€”NHCON(H)â€”, â€”NHSO2â€”, â€”SO2N(H)â€”, â€”C(O)â€”Oâ€”, â€”NHSO2NHâ€”, â€”Oâ€”COâ€”, R18 and R19 are independently selected from the group consisting of aryl, C1-C6 alkyl, C1-C6 alkylaryl, C1-C6 alkoxy, and C1-C6 alkoxyaryl; R20 is selected from the group consisting of aryl, C1-C6 alkyl, and C1-C6 alkylaryl; R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, aryl, C1-C6 alkyl, and C1-C6 alkylaryl; and wherein R7 and R8 may be taken together to form a ring having the formula â€”(CH2)mâ€”Xâ€”(CH2)nâ€” bonded to the nitrogen atom to which R7 and R8 are attached, and/or R5 and R6 may, independently, be taken together to form a ring having the formula â€”(CH2)mâ€”Xâ€”(CH2)nâ€” bonded to the nitrogen atoms to which R5 and R6 are attached, wherein m and n are, independently, 1, 2, 3, or 4; X is selected from the group consisting of â€”CH2â€”, â€”Oâ€”, â€”Sâ€”, â€”S(O2)â€”, â€”C(O)â€”, â€”CON(H)â€”, â€”NHC(O)â€”, â€”NHCON(H)â€”, â€”NHSO2â€”, â€”SO2N(H)â€”, â€”C(O)â€”Oâ€”, â€”Oâ€”C(O)â€”, â€”NHSO2NHâ€”, or a pharmaceutically acceptable salt thereof.