Patent ID: 6046233
Filing Date: 2000-04-04
Classification: A61K,A61P

Abstract:
A method of treating cor pulmonale comprising administering to a patient of cor pulmonale an effective amount of a 5,6,7-trinor-4,8-inter-m-phenyleneprostaglandin I.sub.2 derivative or a pharmacologically acceptable salt thereof represented by the following formula (I): ##STR5## wherein R.sub.1 is hydrogen, --COOR.sub.7, (wherein R.sub.7 is an ester group, or a pharmacologically acceptable cation), --CH.sub.2 OH, or a pharmacologically acceptable cation;A is --(CH.sub.2)n--, --(CH.sub.2)m--CH.dbd.CH--(CH.sub.2)p--, --(CH)m--C.tbd.C--(CH.sub.2)p-- or --CH.sub.2 --O--CH.sub.2 -- (wherein n is an integer of 0 to 3, and each of m and p is 0 or 1),R.sub.2 is (1) a straight chain or branched alkyl group having 5 to 10 carbon atoms, (2) --C.sub.t H2.sub.t --OR.sub.3 (wherein t indicates an integer of 1 to 5, and R.sub.3 indicates a straight chain or branched alkyl group having 1 to 5 carbon atoms, or a phenyl group), (3) --C.sub.t H2.sub.t --CH.dbd.C(R.sub.4) (R.sub.5) (wherein t indicates the same as defined above, and R.sub.4 and R.sub.5 each indicate hydrogen, a methyl group, an ethyl group, a propyl group or a butyl group); or (4) --C.sub.t H2.sub.t --C.tbd.C--R.sub.6 (wherein t indicates the same as defined above, and R.sub.6 indicates hydrogen, a methyl group or an ethyl group); andformula (I) indicates d-, l- and dl-forms.