Patent ID: 8871943
Filing Date: 2014-10-28
Classification: C07D

Abstract:
1. A process for preparing a compound of Formula (I): or a salt, solvate, isotopologue, or polymorph thereof, wherein: W represents Cl, Br or I; R represents C R (a) fluorinating a compound of Formula (II): wherein A with a source of fluoride ion to form a compound of Formula (III): wherein B and transforming the compound of Formula (III) to a compound of Formula (IV): (b) halogenating a compound of Formula (IV) with a halogen source to form a compound of Formula (V): and (c) coupling a compound of Formula (VI) wherein with a compound of Formula (VII) wherein Met is Zn-halide, Zn—R, tri-(C in the presence of a transition metal catalyst to form a compound of Formula (VIII): wherein transformation (c) may occur prior to, between, or after transformations (a) and (b).