Patent ID: 7405325
Filing Date: 2008-07-29
Classification: C07C

Abstract:
1. A process for the preparation of 4-hydroxyalkylamino-2-nitro-anisoles of the general formula (I) wherein m is 2 or 3; wherein a 4-halogeno-3-nitro-aniline of formula (II) is caused to react with a chloroalkyl-chloroformate, followed by an alkaline ring closure of the resulting carbamate and a nucleophilic replacement of the halogeno atom by a methoxy group to form a derivative of formula (IV), and then followed by a ring opening of the resulting cyclic carbamate by a treatment with methanolic alkali metal hydroxide, and finally followed by a neutralization with an inorganic or organic acid, wherein the complete reaction is executed in a non-aqueous medium.