Patent ID: 6649640
Filing Date: 2003-11-18
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:Ht is pyrrol-3-yl; said pyrrol-3-yl having R3 and QR4 substituents; Aâ€”B is Nâ€”O or Oâ€”N; R1 is hydrogen or NHR; T is a valence bond; Q is â€”C(O)â€” or â€”SO2â€”; each R is independently selected from hydrogen or an optionally substituted aliphatic group having one to six carbons; R2 is an aryl group substituted with up to three R8 substituents; R3 is hydrogen; R4 is â€”NHR6; R6 is â€”(CH2)yCH(R7)2; y is 0-6; each R7 is independently selected from R, aryl, or hydroxyalkyl, wherein said aryl ring is optionally substituted with halogen, Râ€², ORâ€², CO2Râ€², or SO2Râ€², wherein each Râ€² is independently selected from hydrogen or a C1-6 aliphatic group; and each R8 is independently selected from halogen, â€”Râ€², or â€”ORâ€²; wherein each Râ€² is independently selected from hydrogen or an optionally substituted aliphatic group.