Patent ID: 6316616
Filing Date: 2001-11-13
Classification: B01J,C07C,C40B,Y02P

Abstract:
A catalyst represented by the following structure: ##STR56##whereinB represents an optionally substituted aromatic or heteroaromatic group;C.sub.1, C.sub.2 and C.sub.3 each represent chiral carbon atoms;X represents O, S or NH;J represents a linker group with 2-6 heavy atoms in its backbone including at least one functional group capable of acting as a hydrogen bond donor;R.sub.103 represents either a hydrogen bond donor, a Lewis basic group, or a group with both characteristics;R.sub.104 represents an aliphatic or cycloaliphatic substituent of up to 20 carbons (preferably 2-10);R.sub.105 is absent, or represents one or more additional substituents of B selected from the group consisting of alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80 ; andR.sub.106 and R.sub.107 each independently represent alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80, orR.sub.106 and R.sub.107 taken together with C.sub.2 and C.sub.3 form a ring having from 4 to 8 atoms in the ring;R.sub.108 and R.sub.109 each independently represent an alkyl, represent alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80, with the proviso that R.sub.108 and (C(X)R.sub.109) are not identical (this proviso is implied by the aforementioned chirality of C.sub.1);R.sub.80 represents an unsubstituted or substituted aryl, a cycloalkyl, a cycloalkenyl, a heterocycle, or a polycycle; andm is an integer in the range 0 to 8 inclusive.