Patent ID: 8592583
Filing Date: 2013-11-26
Classification: C07D

Abstract:
1. A process for preparing a 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamide of the formula (I): wherein R1 and R2 independently represent hydrogen, halogen, C a) coupling an acetal of formula (II): wherein R3 is C wherein R5 is C b) acetylating the resultant compound of the formula (IV): with an acetyl halide or acetic anhydride in the presence of a Lewis acid; c) reacting the resultant compound of formula (V): with a C d) reacting the resultant enaminone of formula (VI): with guanidine or a salt thereof; e) hydrolyzing the carboxylic ester group of the resultant compound of formula (VII): f) condensing the carboxylic acid group of the resultant compound of formula (VIII): with a form of ammonia, to give the carboxamide of formula (I); and, optionally, converting it into a pharmaceutically acceptable salt.