Patent ID: 6465472
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of the Formula I: or a pharmaceutically acceptable salt, ester or amide thereof, wherein:R1 is alkyl, haloalkyl, aminoalkyl, C1-10 alkylaminoalkyl, di(C1-10)alkylaminoalkyl, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, imidazolylalkyl, carbocycloalkyl, morpholinylalkyl, pyrrolidinylalkyl, N-methylpyrrolidinylalkyl, piperidinylalkyl, hydroxyalkyl, cyanoalkyl, alkanoylamidoalkyl, alkanoyloxyalkyl, azidoalkyl, alkenyloxyalkyl, or alkoxyalkyl; R6 and R7 are taken together to form â€”OCH2Oâ€”, â€”OCH2CH2Oâ€”, â€”Oâ€”CF2â€”Oâ€”, â€”CH2CH2CH2â€”, â€”CH2CH2CH2CH2â€”, or â€”N(R9)â€”COâ€”Oâ€”, wherein R9 is lower alkyl optionally substituted with phenyl; R5 is hydrogen; R8 is selected from the group consisting of hydrogen and alkyl; X is O or S; and Y is phenyl, biphenyl, indenyl, quinolinyl, or pyridyl, optionally substituted with one or more substituents selected from the group consisting of hydrogen, halo, C1-10alkyl, nitro, amino, and alkoxy, or â€ƒwherein R2 is H, alkyl, halo, amino, alkoxy, or nitro; and R3 and R4 are taken together to form â€”OCH2Oâ€”, â€”OCH2CH2Oâ€”, â€”Oâ€”CF2â€”Oâ€”, â€”CH2CH2CH2â€”, â€”CH2CH2CH2CH2â€”, â€”Oâ€”CH2â€”CH2â€”, â€”N&boxH;CHâ€”Oâ€”, â€”NHâ€”COâ€”Oâ€”, â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, or â€”Oâ€”CH&boxH;CHâ€”; with the proviso that when R6 and R7 are taken together as â€”OCH2Oâ€”, then Y is not unsubstituted phenyl or a phenyl group that is substituted with one or more substituents selected from the group consisting of hydrogen, halo, C1-10 alkyl, nitro, amino, and alkoxy; or when R6 and R7 are taken together as â€”OCH2Oâ€” and Y is 3,4-methylenedioxyphenyl, R1 is not C1-5 alkyl, C3-6 cycloalkyl, or C3-6 cycloalkyl-C1-3 alkyl; or when R6 and R7 are taken together as â€”CH2CH2CH2â€”or â€”CH2CH2CH2CH2â€”, Y is not unsubstituted phenyl.