Patent ID: 6087337
Filing Date: 2000-07-11
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method of treating a mammal suffering from benign or malignant skin melanomas or metastases of malignant melanomas, comprising topically administering to said mammal at the site of said melanoma an effective amount of a cyclic octapeptide somatostatin analog of the formula: ##STR11## wherein A.sub.1 is D-Phe, N-Ac-D-hArg(Et).sub.2 -Gly, D-.beta.-Nal, or ##STR12## wherein the C bonded to Z.sub.3 has a D-configuration, wherein each Z.sub.1 and Z.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO, where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl, or R.sub.2 OCO, where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl, wherein when one of Z.sub.1 or Z.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other is H;Z.sub.3 is CH.sub.2 -Z.sub.4, wherein Z.sub.4 is pentafluorophenyl, naphthyl, pyridyl, phenyl, or o-, m-, or p-substituted phenyl, where the substituent is a halogen, NH.sub.2, NO.sub.2, OH, or C.sub.1-3 alkyl;A.sub.3 is Phe, o-, m-, or p-substituted X-Phe, where X is a halogen, H, NH.sub.2, NO.sub.2, OH, or C.sub.1-3 alkyl, pentafluoro-Phe, .beta.-Nal, or Tyr;A.sub.6 is Thr, Ser, Val, or .alpha.-aminobutyric acid; andA.sub.8 is Thr-NH.sub.2, Trp-NH.sub.2, L-.beta.-Nal-NH.sub.2, or Thr(ol); or a pharmaceutically acceptable salt thereof.