Patent ID: 8524915
Filing Date: 2013-09-03
Classification: C07C,C07D

Abstract:
1. A process for the preparation of the compound of formula I which process comprises a) reacting a compound of formula II wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula III wherein X is chloro or bromo; reacting the halobenzyne of formula III so formed with a fulvene of formula IV wherein R wherein R b) hydrogenating the compound of formula V in the presence of a suitable metal catalyst to a compound of formula VI wherein R c) ozonising the compound of formula VI to a compound of formula VII wherein X is chloro or bromo; d) converting the compound of formula VII in the presence of a phosphane and CCl wherein X is chloro or bromo; and either e1) reacting the compound of formula VIII with NH and f) reacting the compound of formula IX in the presence of a base with the compound of formula X to the compound of formula I; or e2) reacting the compound of formula VIII wherein X is chloro or bromo; in the presence of a solvent, a base, a copper catalyst and at least one ligand with the compound of formula Xa to the compound of formula I.