Patent ID: 8232314
Filing Date: 2012-07-31
Classification: A61K

Abstract:
1. A method of preventing a condition associated with sensory hair cell death associated with aminoglycoside treatment, the method comprising administering a sufficient amount of a compound selected from the group consisting of: 2-({[(4-chlorophenyl)amino]carbonyl}amino)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (F5), 2-{[({2,2,2-trichloro-1-[(4-methoxybenzoyl)amino]ethyl}amino)carbonothioyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (C20 H21 Cl3 N4 O3 S2) (H10), and mixtures thereof, wherein said compound inhibits lateral line hair cell death in a zebrafish.