Patent ID: 8298561
Filing Date: 2012-10-30
Classification: A61F,A61K,A61L,A61M,A61P

Abstract:
1. A method of treating type 2 diabetes mellitus in a subject in need of treatment, comprising: providing continuous delivery of exenatide from an osmotic delivery device, the osmotic delivery device comprising a first chamber and a second chamber, the first chamber containing the osmotic engine, wherein (i) substantial steady-state delivery of the exenatide at a therapeutic concentration is achieved within a time period of 5 days or less after implantation of the osmotic delivery device in the subject, and (ii) the substantial steady-state delivery of the exenatide from the osmotic delivery device is continuous over an administration period of at least about 3 months at a mcg/day dose of exenatide selected from the group consisting of about 10 mcg/day, about 20 mcg/day, about 30 mcg/day, about 40 mcg/day, about 60 mcg/day, and about 80 mcg/day.