Patent ID: 8088060
Filing Date: 2012-01-03
Classification: A61F,A61L

Abstract:
1. An implantable medical device having a lumen, a luminal surface, a tissue-contacting surface, and a coating; said coating comprising: one or more covalently bound luminal surface layers of a matrix comprising a natural fiber selected from elastin, tropoelastin; cross-linked tropoelastin or combinations thereof; a tissue-contacting biodegradable and biocompatible synthetic polymer layer comprising a therapeutically effective amount of one or more intimal hyperplasia inhibitory pharmaceutical substances, and one or more pharmaceutically acceptable carriers on said tissue-contacting surface; and a therapeutically effective amount of a ligand selected from an antibody, an antibody fragment and combinations thereof, said ligand being covalently attached to said matrix and configured specifically to bind in situ to a cell surface antigen or cell membrane molecule comprising CD133, CD45, CD34, CD31, CD14, CDw90, CD117, VEGFR-1, VEGFR-2, Muc-I8 (CD146), CD130, stem cell antigen (Sca-1), stem cell factor 1 (SCF/c-Kit ligand), Tie-2, or MHC-H-2Kk of circulating autologous endothelial progenitor cells in peripheral blood for in vivo capture and proliferation of said endothelial progenitor cells to form a functional endothelial layer on said luminal surface of the implantable medical device, in situ.