Patent ID: 6162800
Filing Date: 2000-12-19
Classification: A61K,A61P,C07F,C07K

Abstract:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR14## wherein: ##STR15## R.sub.5 is H or deuterium; R.sub.6 is OR.sub.8 or NHOH;each R.sub.8 is independently H, alkyl or aralkyl;R.sub.7 is H, CH.sub.2 F, CHR.sub.13 O(CO).sub.0-1 -aryl, CHR.sub.13 OP(O)(R.sub.14)(R.sub.15), ##STR16## wherein: R.sub.13 is H or alkyl;R.sub.14 is alkyl or aryl;R.sub.15 is alkyl or aryl;R.sub.16 is alkyl, aryl, aralkyl or heteroaryl;R.sub.17 is H, alkyl, CF.sub.3 or CF.sub.2 CF.sub.3 ;R.sub.2 is alkyl, aryl or heteroaryl;R.sub.3 and R.sub.4 are independently H, alkyl or aralkyl; andR.sub.1 is --R.sub.19 --R.sub.[2], --R.sub.19 --NR.sub.9 R.sub.11, --OR.sub.22, or --NR.sub.9 R.sub.11 ;R.sub.19 is (CR.sub.3 R.sub.4)--.sub.0-4 ;R.sub.22 is alkyl, aryl, or aralkyl;R.sub.9 is H, alkyl, or aralkyl; andR.sub.11 is H, alkyl, or aralkyl.