Patent ID: 8968392
Filing Date: 2015-03-03
Classification: A61F,A61K,A61L,A61P

Abstract:
1. A method of inhibiting vascular intimal hyperplasia using a stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer coating substantially completely over the first coated layer, the method comprising: controlling the rate of release of argatroban from the stent in phosphate buffered saline at 37° C., which is measured on the first day and the second day subsequent to immersion of the stent in the phosphate buffered saline, to be 3 μg/cm placing the stent within a blood vessel; and wherein argatroban is released from the stent, thereby inhibiting the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.