Patent ID: 8404859
Filing Date: 2013-03-26
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: X is N or CH; R1 is indole, oxoindole, indazole or substituted phenyl, said substituted phenyl being mono- or bi-substituted independently with hydroxy, halogen, alkoxy or lower alkyl; R2 is —(CH R3 is hydrogen, methyl, trifluoromethyl, halogen or cyano; R4 is indazole, benzimidazole, unsubstituted heteroaryl, heteroaryl mono- or bi-substituted independently with alkoxy or hydroxy, unsubstituted phenyl or phenyl mono- or bi-substituted independently with hydroxy, methyl, halogen or —COOH; R5 is hydrogen, lower alkyl, alkoxy, cycloalkyl, heterocycloalkyl, lower alkyl-cycloalkyl, lower alkyl-heterocycloalkyl, —(CH R6, R7 and R8, independently of each other, are hydrogen, lower alkyl or alkoxy; and n is 1, 2 or 3, or a pharmaceutically acceptable salt thereof.