Patent ID: 8513390
Filing Date: 2013-08-20
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An activatable antibody that in an activated state binds Epidermal Growth Factor Receptor (EGFR),the activatable antibody comprising: an antibody or an antigen binding fragment thereof (AB) that specifically binds to EGFR; a masking moiety (MM) that inhibits the binding of the AB in an uncleaved state to EGFR and wherein the MM comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 1, 218-220, 236-265 and 266; and at least one cleavable moiety (CM) coupled to the AB, wherein the CM is a polypeptide that functions as a substrate for a protease selected from the group consisting of urokinase-type plasminogen activator (uPA), legumain, and matriptase (MT-SP1) and the substrate for uPA comprises the amino acid sequence LSGRSDNH (SEQ ID NO: 271).