Patent ID: 6034103
Filing Date: 2000-03-07
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I): ##STR12## wherein A is --N.dbd.;Z.sup.1 is --O--, --N(R.sup.8)-- or --CH.sub.2 O--;Z.sup.2 is --O--, --N(R.sup.8)-- or --OCH.sub.2 --;R.sup.1 and R.sup.3 are independently hydrogen, fluoro, chloro, haloalkyl, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, or --N(R.sup.8)S(O).sub.2 R.sup.8 ;R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkylcarbonyl, carboxy, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or tetrazolylalkyl);or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, amidino, 1-iminoethyl, carboxy, carboxyalkyl, alkoxycarbonyl or alkoxycarbonylalkyl);R.sup.4 is hydrogen, --OR.sup.8 or --N(R.sup.8)R.sup.9 ;R.sup.5 is --C(NH)NH.sub.2 ;R.sup.6 is (1,2)-imidazolyl (optionally substituted by alkyl) or (1,2)-imidazolinyl (optionally substituted by alkyl);R.sup.7 is hydrogen, halo, alkyl, --OR.sup.8, --C(O)N(R.sup.8)R.sup.9 ; andR.sup.8 and R.sup.9 are independently hydrogen, methyl, ethyl or phenyl,or a pharmaceutically acceptable salt thereof.