Patent ID: 6610724
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of the formula: and pharmaceutically acceptable salts thereof wherein:R1 is R2, COR3, CONH2, CONR2R3, COOR3, or SO2R3; R2 is H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, or heteroarylium; R3 is alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl; â€ƒwherein i, j=0 or 1 but cannot both be 1, and Y is optionally substituted ethylene, alkene, alkyne, or any 2 adjacent carbon atoms of a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms; R4 is R9; each R5, R6, R7, R8 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, halo, or hydroxy, alkoxy, amino, NR15R16, thio, or alkylthio with the proviso that only one such heteroatom group is bonded to any one carbon atom; â€ƒwherein Z is NR12; each R10, R11 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, halo, hydroxy, alkoxy, alkylcarbonyloxy, carboxy, alkyloxycarbonyl, amino, NR13R14, carbamoyl, ureido, thio, or alkylthio; and each R12, R13, R14, R15, and R16 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl.