Patent ID: 9012439
Filing Date: 2015-04-21
Classification: A61K,A61P

Abstract:
1. A method of treating a patient for low platelet levels, the method comprising: administering to a patient having a low platelet level an effective amount of an electrophilic compound that is suitable to cause an increase in platelet production by megakaryocytes, wherein the electrophilic compound is a compound according to formula (II) or formula (III): wherein R 2 is CN and R 7 is CN; wherein Y is hydroxy, an unsubstituted C 1 -C 14 -alkoxy, an unsubstituted C 1 -C 14 -alkylamino, -D-Glu(OMe) 4 , -D-Glu(OAc) 4 , -L-Ara(OAc) 3 , or -D-Gal-(OAc) 4 ; or a pharmaceutically acceptable salt thereof.