Patent ID: 7488726
Filing Date: 2009-02-10
Classification: A61P,C07D

Abstract:
1. A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein (a) A is H, OH, O—(C W is O, S, or NR X is H or COR Y is H, Hal, or OR each of R with the proviso that R 4 and R 4′ cannot be H at the same time, wherein when each of m and n is 1: each of R R C 1-2 linkage, which optionally contains a non-vicinal O, S, or N(R 23 ), R 7 and R 14 together form a single bond or a C 1 linkage, or R 7 and R 16 together form a single bond or a C 1 linkage, wherein R 23 is H, C 1-6 alkyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 24b , CO 2 R 24a , CONR 24a R 24b , CSR 24b , COSR 24a , CSOR 24a , CSNR 24a R 24b , SO 2 R 24a , or SO 2 NR 24a R 24b , wherein R 24a is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, R 24b is H, C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, or R 24a and R 24b together form a C 2-6 linkage, optionally containing a non-vicinal O; R R R R R R R R R R and when m is 0 and n is 1: R each of R R R R R R R R R (b) A is OH; X is H; W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, R 21 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 1-4 alkaryl, or C 1-4 alkheteroaryl, R 20 is H, C 1-6 alkyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 19 , CO 2 R 19 , CONHR 19 , CSR 19 , COSR 19 , CSOR 19 , CSNHR 19 , SO 2 R 19 , or SO 2 NHR 19 , wherein R 19 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, (c) A is OH; X is COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, R 21 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 1-4 alkaryl, or C 1-4 alkheteroaryl, R 20 is H, C 1-6 alkyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 19 , CO 2 R 19 , CONHR 19 , CSR 19 , COSR 19 , CSOR 19 , CSNHR 19 , SO 2 R 19 , or SO 2 NHR 19 , wherein R 19 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, (d) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H; (e) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, R 22 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 1-4 alkaryl, C 1-4 alkheteroaryl, R 20 is H, C 1-6 aryl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 24 , CO 2 R 24 , CONHR 24 , CSR 24 , COSR 24 , CSOR 24 , CSNHR 24 , SO 2 R 24 , or SO 2 NHR 24 , wherein R 24 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, and each of r and s is, independently, 1-2, (f) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, T is O, S, NR 26 , or a bond, where each of R 21 , R 25 , and R 26 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 2-9 heterocyclyl, C 1-4 alkaryl, or C 1-4 alkheteroaryl, or R 25 and R 26 together form a 3-8-membered ring, with the ring optionally containing a non-vicinal oxygen, (g) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, R 27 is H, C 1-6 alkyl, C 1-4 alkaryl, or C 1-4 alkheteroaryl; R 28 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 2-9 heterocyclyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, OR 24b , or NR 24a R 24b , wherein R 24a is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, R 24b is H, C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, or R 24a and R 24b together form a C 2-6 linkage, optionally containing a non-vicinal O; and each of r and s is, independently, 1-2, (h) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R 4 and R 4′ cannot be H, ═E is ═O or (H,H), R 22 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 24 , CO 2 R 24 , CONHR 24 , CSR 24 , COSR 24 , CSOR 24 , CSNHR 24 , SO 2 R 24 , or SO 2 NHR 24 , wherein R 24 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, r is 1-2, and s is 0-1, (i) A is H or OH; X is H or COCH W and Y are defined as above; and each of R wherein both R wherein said C 1-9 heteroaryl is selected from the group consisting of furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, tetrazolyl, oxadiazolyl, oxatriazolyl, pyridyl, pyridazyl, pyrimidyl, pyrazyl, triazyl, benzofuranyl, isobenzofuranyl, benzothienyl, indole, indazolyl, indolizinyl, benzisoxazolvl, quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, naphtyridinyl, phthalazinyl, phenanthrolinyl, purinyl, and carbazolyl.