Patent ID: 7795434
Filing Date: 2010-09-14
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A process for the manufacture of a chelidonine reaction product having a quaternary nitrogen according to formula (I), wherein R1 is a hydrogen, or a methyl or ethyl residue and wherein the chelidonine reaction product is present in water-soluble form as a salt of a strong acid, the process comprising: a) providing a reaction mixture comprising an organic solvent, an alkaloid which is chelidonine, and an alkylating agent, and carrying out an alkylation reaction by reacting the chelidonine with the alkylating agent in the presence of the organic solvent, so as to form a chelidonine reaction product having a quaternary nitrogen; b) after termination of the alkylation reaction, subjecting the resulting reaction mixture to at least one washing step with an aqueous solvent or water, to remove water-soluble compounds present in the reaction mixture; and c) subjecting the washed reaction mixture to a treatment with a strong acid in gaseous or liquid form, thereby converting the quaternary chelidonine reaction product in the reaction mixture into a water-soluble salt.