Patent ID: 8236847
Filing Date: 2012-08-07
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating diabetes, insulin resistance, hyperglycemia, dyslipidemia or elevated blood levels of free fatty acids or glycerol, obesity, Syndrome X, dysmetabolic syndrome, retinopathy, neuropathy, nephropathy, cataracts, hypertriglyceridemia, hyperinsulinemia, atherosclerosis, impaired glucose homeostasis, impaired glucose tolerance, infertility, polycystic ovary syndrome, arthritis, allograft rejection in transplantation, scleroderma, multiple sclerosis, necrotizing enteritis, microvillus inclusion disease, celiac disease, inflammatory bowel syndrome, anorexia nervosa, osteoporosis, lupus erythematosis, psoriasis, Crohn's disease, or ulcerative colitis, which comprises administering to a mammalian species in need of treatment or an effective amount of a crystalline compound in a form selected from H2-1 (1HCl), H2-1 (2HCl), H0.75-3, H1.67-1, P-5, N-3, H-1 (1H 2 O), H-1 (1PhCO 2 H/1H 2 O), N-1, and mixtures thereof, wherein the crystalline compound of form H2-1 (1HCl) has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 6.8±0.1, 11.1±0.1, 13.7±0.1, 14.6±0.1, 15.2±0.1, 16.4±0.1, 17.0±0.1, 20.2±0.1, and 21.1 ±0.1; wherein the crystalline compound of form H2-1 (2HCl) has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 7.2±0.1, 8.6±0.1, 11.6±0.1, 14.3±0.1, 15.7±0.1, 19.5±0.1, and 22.5±0.1; wherein the crystalline compound of form H0.75-3 has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 5.0±0.1, 7.0±0.1, 8.1±0.1, 11.4±0.1, 13.4±0.1, 14.0±0.1, 14.5±0.1, 18.6±0.1, 19.4±0.1, and 20.0±0.1; wherein the crystalline compound of form H1.67-1 has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 5.4±0.1, 7.0±0.1, 13.8±0.1, 14.2±0.1, 14.6±0.1, 16.1±0.1, 16.6±0.1, 18.6±0.1, 19.0±0.1, and 20.3±0.1; wherein the crystalline compound of form P-5 has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 6.2±0.1, 10.7±0.1, 14.5±0.1, 15.0±0.1, 15.6±0.1, 16.2±0.1, 18.1±0.1, 18.7±0.1, and 21.1 ±0.1; wherein the crystalline compound of form N-3 has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 5.2±0.1, 7.9±0.1, 10.8±0.1, 11.5±0.1, 13.0±0.1, 14.6±0.1, 15.6±0.1, 15.9±0.1, and 16.5±0.1; wherein the crystalline compound of form H-1 (1H and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 12.4±0.1, 13.3±0.1, 13.6±0.1, 14.7±0.1, 16.2±0.1, 18.2±0.1, 19.9±0.1, 20.9±0.1, 21.9 ±0.1, and 22.4±0.1; wherein the crystalline compound of form H-1 (1PhCO and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 6.6±0.1, 8.3±0.1, 15.3±0.1, 16.1±0.1, 16.9±0.1, 17.5±0.1, 17.8±0.1, 18.6±0.1, and 21.3±0.1; and wherein the crystalline compound of form N-1 has structure and has powder x-ray diffraction peaks at 2θ values (CuKα λ−1.5418 Å) of 5.5±0.1, 7.0±0.1, 11.1±0.1, 14.4±0.1, 15.1±0.1, 15.7±0.1, 16.4±0.1, 16.8±0.1, and 19.6±0.1, alone or in combination with a therapeutic agent.