Patent ID: 8536194
Filing Date: 2013-09-17
Classification: A61P,C07D

Abstract:
1. A method of treating or preventing a disease mediated by p38 which comprises administering to a subject in need thereof a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof: wherein: A represents N or N R R R R R each R each R each R each R each R each R each R each R R each R Het in the above definitions represents pyridine, pyrazine, pyrimidine, pyridazine, 2(1H)-pyridone, 2(1H)-pyrazinone, 2(1H)-pyrimidinone or 2(1H)-pyridazinone; Cy or Cy* in the above definitions represent a partially unsaturated, saturated or aromatic 3- to 7-membered monocyclic or 8- to 12-membered bicyclic carbocyclic ring, which optionally contains from 1 to 4 heteroatoms selected from N, S and O, which can optionally contain 1 or 2 oxo groups when the ring is saturated or partially unsaturated, and wherein said ring or rings can be bonded to the rest of the molecule through a carbon or a nitrogen atom; with the proviso that when R