Patent ID: 6610660
Filing Date: 2003-08-26
Classification: A61P,C07C,C07D,C07H,Y02A

Abstract:
An O2-substituted diazeniumdiolate having the formula wherein X is selected from the group consisting of an amino, a polyamino, a C1-C24 aliphatic, a C6-C30 aryl, a C3-C30 heteroaromatic having 1 to 3 heteroatorms selected from the group consisting of oxygen, nitrogen and sulfur, a C3-C30 nonaromatic cyclic, and an oximyl, and Q is selected from the group consisting of an acridinyl, an anthracenyl, a benzimidazolyl, a benzisoxazolyl, a benzofuryl, a benzothienyl, a benzoxazolyl, a benzopyrazolyl, a benzothiazolyl, a carbazolyl, a chlorophyllyl, a cinnolyl, a furyl, an imidazolyl, an indolyl, an isobenzofuryl, an isoindolyl, an isoxazolyl, an isothiazolyl, an isoquinolyl, a naphthyl, an oxazolyl, a phenanthryl, a phenanthridinyl, a phenothiazinyl, a phenoxazinyl, a phenyl, a phthalimidyl, a phthalazinyl, a phthalocyaninyl, a pteridinyl, a purinyl, which isoptionally part of a nucleic acid, a ribosylpurinyl, a pyrazinyl, a pyrazolyl, a pyridazyl, a pyridyl, a pyrimidyl, which is optionally part of a nucleic acid, a ribosylpyrimidyl, a pyrrocolinyl, a pyrryl, a quinolyl, a quinoxalinyl, a quinazolinyl, a sydnonyl, a tetrazolyl, a thiazolyl, a thienyl, a thyroxinyl, a triazinyl, and a triazolyl, wherein a ring atom of Q is bonded to the O2-oxygen, wherein X and Q are optionally substituted, with the proviso that, when Q is an imidazolyl, X is not an imidazolyl.