Patent ID: 6664287
Filing Date: 2003-12-16
Classification: C07C,C07D

Abstract:
A compound having the formula wherein R and R1 are defined according to criteria selected from the group consisting of: (1) R and R1 are both attached to the same carbonyl group to form a 1,3-dithian-2-one ring; (2) R and R1 are both attached to the same carbon atom to form a 1,3-dithiane ring; (3) With the exception that R and R1 together are not H, R and R1 are separately selected from a group consisting of: H, an acyl group â€”COR4, â€”CH2OCOR4, CH(Rj)OCOR4; and each of R2, R3 and R4 is separately selected from the group consisting of: H; an optionally substituted alkyl; a branched alkyl; a cycloalkyl; a bicycloalkyl; a tricycloalkyl; a bicycloalkenyl; a tricycloalkenyl; an alkenyl; an allenyl; a cycloalkenyl; an alkylcycloalkyl; an alkylcycloalkenyl; an alkynyl; an aryl; an arylmethylenyl; an arylethylenyl; a heteroalkyl; a heterocyclic; a heteroaromatic; an alkylheterocyclic; an alkylheteroaryl; an alcohol; an ether OR5; a mono-, di-, or unsubstituted amine (NR6R7); an ester (COOR8); an aldehyde; a formate; a formamide (NR0CHO); a mono-, di-, or unsubsituted amide (CONR9R10); a ketone (COR11); an acyl ester (OCOR12); an acyl carbonate (OCOOR13); an acyl carbamate (OCONR14R15); an acyl urea (NR16CONR17R18); a halide; a nitro; a nitroso; a hydrazide (R19NNR20R21); an acyl hydrazide (R22CONR23NR24R25); a diacyl hydrazide (R26CONR27NR28COR29); a sulfide (R30Sâ€”); a sulfoxide (R31SO); a sulfone (R32SO2â€”); a sulfonamide (R33R34NSO2â€”); a sulfonamidyl (R35NSO2R36); a disulfide (R37SSâ€”); an acyl thioyl (R38COSâ€”); a thioyl carbonate (R39OCOSâ€”); a thioyl carbamate (R40R41NCOSâ€”); a dithioester (â€”CSSR42); a thiocarbonate (â€”SCSSR43); an amidinyl (R44R45Câ€”C(&boxH;NH)NH2); a guanidinyl (R46Nâ€”C(&boxH;NH)NH2); an oxime (R47C&boxH;NOR48); a hydrazide (R49C&boxH;Nâ€”NR50R51); an acyl hydrazide (R52C&boxH;Nâ€”NR53COR54); an antioxidant molecule linked through an ester or other carbonyl bond; and Rj is defined according to criteria selected from the group consisting of: (1) Rj is selected from the group consisting of: H; an optionally substituted alkyl; a branched alkyl; a cycloalkyl; a bicycloalkyl; a tricycloalkyl; a bicycloalkenyl; a tricycloalkenyl; an alkenyl; an allenyl; a cycloalkenyl; an alkylcycloalkyl; an alkylcycloalkenyl; an alkynyl; an aryl; an arylmethylenyl; an arylethylenyl; a heteroalkyl; a heterocyclic; a heteroaromatic; an alkylheterocyclic; an alkylheteroaryl; an ether (OR5); a di-substituted amine (NR6R7); an ester (COOR8); an aldehyde; a mono-, di- or unsubsituted amide (CONR9R10); a ketone (COR11); a sulfide (R30Sâ€”); a sulfoxide (R31SOâ€”); and a sulfone (R32SO2â€”); or (2) Rj comprises a functional group separated from the Rj bearing C atom by at least one additional C atom wherein said functional group is selected from the group consisting of; a mono-, or unsubsituted amine (NR6R7); a formate; formamide (NR0CHO); an acyl ester (OCOR12); an acyl carbonate (OCOOR13); an acyl carbamate (OCONR14R15); an acyl urea (NR16CONR17R18); a halide; a nitro; a nitroso; a hydrazide (R19NNR20R21); an acyl hydrazide (R22CONR23NR24R25); a diacyl hydrazide (R26CONR27NR28COR29); a sulfonamide (R33R34NSO2â€”); a sulfonamidyl (R35NSO2R36); a disulfide (R37SSâ€”); an acyl thioyl (R38COSâ€”); a thioyl carbonate (R39OCOSâ€”); a thioyl carbamate (R40R41NCOSâ€”); a dithioester (â€”CSSR42); a thiocarbonate (â€”SCSSR43); an amidinyl (R44R45Câ€”C(&boxH;NH)NH2); a guanidinyl (R46Nâ€”C(&boxH;NH)NH2); an oxime (R47C&boxH;NOR48); a hydrazide (R49C&boxH;Nâ€”NR50R51); an acyl hydrazide (R52C&boxH;Nâ€”NR53COR54); an antioxidant molecule linked through an ester or other carbonyl bond; and n=0-8; and m=0-8; and X is selected from the group consisting of: H, OH, R55, â€”OR56, â€”SR57, â€”NR58R59, â€”PO(OR60)2, â€”SOR61, â€”SO2R62, â€”SO2NR63R64, COOH; COOR65; CONR66R67, F, Cl, Br, a substituted aryl, an unsubstituted aryl, a heteroaryl, an arylalkyl, an alkylheteroaryl, a heterocyclic, a saturated ring, and an unsaturated ring; and Y is selected from the group consisting of: H, OH, R68, â€”OR69, â€”SR70, â€”NR71R72, â€”PO(OR73)2; â€”SOR74, â€”SO2R75, â€”SO2NR76R77, COOH; COOR78; CONR79R80, F, Cl, Br, a substituted aryl, an unsubstituted aryl, a heteroaryl, an arylalkyl, an alkylheteroaryl, a heterocyclic, a saturated ring, and an unsaturated ring; and Z is selected from the group consisting of: H, OH, OR81, NHOH, NH82, NHR83, NR84R85, SR86; a normal or branched hydrocarbon from C1-C20, an aryl ring, a substituted aryl ring; an alkylaryl ring, a substituted arylalkyl rings; a heterocyclic ring, a substituted heterocyclic ring; a heteroaromatic ring, a substituted heteroaromatic ring; an alkylheteroaryl ring, a substituted alkylheteroaryl rings; an antioxidant molecule linked through an ester or other carbonyl bond; and R0 and each of R5-R86 is separately selected from the group consisting of: H, an alkyl, a branched alkyl, a cycloalkyl, a bicycloalkyl, a bicycloalkenyl, an alkenyl, an allenyl, a cycloalkenyl, an alkylcycloalkyl, an alkylcycloalkenyl, an alkynyl, an aryl, an arylmethylenyl, an arylethylenyl, a heteroalkyl, a heterocyclic, a heteroaromatic, an alkylheterocyclic, and an alkylheteroaryl; Or a pharmaceutically acceptable salt thereof.