Patent ID: 9212143
Filing Date: 2015-12-15
Classification: A61K,A61P,C07D,C12N,C12Q,G01N

Abstract:
1. A method of inhibiting degranulation, inhibiting respiratory burst, or inhibiting Syk phosphorylation by administering a compound of Formula b) or its isomeric form, to a patient in need of such inhibition, wherein inhibition of degranulation, respiratory burst, or Syk phosphorylation is effective for treating cancer or other proliferative disease, genitourinary disease, hepatic disease, pancreatic disease, pulmonary disease, gastrointestinal disease, osteoporosis, inflammation, allergic reaction, or cardiovascular disease, in the patient, and wherein the compound of Formula b) or its isomeric form have the following formulas: Formula b) or: wherein: R Y is O, S, or NR R R Z, is a substituent defined as R R polymorphs, salts, hydrates, and solvates thereof, wherein the compound is a kinase inhibitor.