Patent ID: 8212035
Filing Date: 2012-07-03
Classification: C07D

Abstract:
1. A process for preparing (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium of Formula I, which comprises, a) protecting the compound of Formula III with a suitable hydroxy protecting group in an organic solvent to obtain a compound of Formula IV, wherein R 2 represents a hydroxy protecting group; b) activating the acid group of the compound of Formula IV with acid activator, followed by treating the resulting intermediate with a metal complex of Formula V, wherein R 3 represents C 1 -C 4 straight chain or branched chain alkyl, aryl, substituted aryl, aralkyl; M represents Mg, Zn, Ca, Cu; n represents an integer selected from 1-2; R 1 represents alkyl or alkoxy; m represents an integer selected from 0 or 1; in an organic solvent to obtain a compound of Formula VI, wherein R 2 and R 3 are as defined above; c) deprotecting the compound of Formula VI with a suitable reagent in an organic solvent, water or mixtures thereof to obtain compound of Formula VII, wherein R 3 is as defined above; d) reducing the compound of Formula VII to obtain a compound of Formula VIII, wherein R 3 as defined above; e) hydrolyzing the compound of Formula VIII and then treating with a source of calcium ions to obtain a compound of Formula I.