Patent ID: 6407064
Filing Date: 2002-06-18
Classification: A61P,C07D

Abstract:
An aminoalcohol derivative represented by formula (I): wherein * represents an asymmetric carbon; andR represents a residue of a monocarboxylic acid derivative represented by the following (i) or (ii), or a residue of a dicarboxylic acid or a derivative thereof represented by the following (iii): (i) a residue of glycine or polyglycine represented by (COCH2NH)mZ, wherein m represents an integer of from 1 to 3; and Z represents an amino-protecting group or an alkanoyl group; (ii) a residue of a carboxylic acid derivative represented by COâ€”Wâ€”Y, wherein W represents an alkylene group or a cycloalkylene group; and Y represents a hydroxyl group, a monosaccharide residue, an aryl group which is optionally substituted, or an alkoxyl group optionally having an oxygen atom in the alkyl chain; (iii) a residue of a dicarboxylic acid or a derivative thereof represented by COâ€”Wâ€”COâ€”X, wherein W represents an alkylene group or a cycloalkylene group; and X represents a hydroxyl group, a chain or cyclic alkoxyl group, an alkyl group, an a-amino acid residue, or NR1R2, in which R1 and R2 are the same or different and each independently represents a hydrogen atom, a chain or cyclic alkyl group optionally having an oxygen atom in the alkyl chain, or a chain or cyclic hydroxyalkyl group optionally having an oxygen atom in the alkyl chain, or a pharmaceutically acceptable salt thereof.