Patent ID: 7148214
Filing Date: 2006-12-12
Classification: A61P,C07D,Y02P

Abstract:
1. A compound of formula or a N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof wherein R wherein each R R R n is 1 or 2; —A—B— represents a bivalent radical of formula  —CH═CH—CH═CH—  (a-3);  wherein each hydrogen atom in the radicals (a-1) to (a-3) may independently be replaced by Z is a bivalent radical of formula with the proviso that the bivalent radicals (b-3), (b-4), (b-5) and (b-6) are connected to the nitrogen of the imidazole ring via their —CH 2 -moiety; wherein p is 1, 2, 3 or 4; L is hydrogen; C L represents a radical of formula  -Alk-NH—CO—Het 2   (c-2) or Alk represents C Y Het Het wherein A aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C with the proviso that 5,6-dihydrospiro[imidazo[2,1-b][3]benzazepine-11[11H],4′-piperidine] and pharmaceutically acceptable addition salts thereof are not included, and 6,11-dihydro-1′-(phenylmethyl)-5H-spiro[imidazo[2,1-b][3]benzazepine-11,4′-piperidine] (E)-2-butenedioate (1:2) is not included.