Patent ID: 8906902
Filing Date: 2014-12-09
Classification: A61P,C07D,C07F

Abstract:
1. A compound of Formula (I) salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof wherein X represents Ring A which is selected from saturated or unsaturated monocyclic C 3-7 cycloalkyl, saturated or unsaturated monocyclic 3-7 membered heterocycle, saturated or unsaturated fused bicyclic C 8-10 cycloalkyl, saturated or unsaturated fused bicyclic 8-10 membered-heterocyclyl, C 6-10 aryl and 5-10 membered heteroaryl and may be optionally substituted; Z an ester, carbamate, phosphate, sulfate or prodrug thereof as defined below or Z 1 is selected from H, OH, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted (CH 2 ) m OC 1-6 alkyl, optionally substituted (CH 2 ) m SC 1-6 alkyl, optionally substituted (CH 2 ) m S(═O)C 1-6 alkyl, halo, optionally substituted haloC 1-3 alkyl, CN and optionally substituted (CH 2 ) m NR a R b where each R a and R b is independently selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl and optionally substituted 4-6-membered heterocycle or R a and R b join together to form an optionally substituted 4-6-membered heterocyclyl where each m is an integer independently selected from 0, 1, 2 and 3; X X where * represents the point of attachment to the carbon ring atom; n is an integer selected from 0, 1, 2 and 3; represents Ring B which is selected from saturated or unsaturated monocyclic C 3-7 cycloalkyl, saturated or unsaturated monocyclic 3-7 membered heterocycle, saturated or unsaturated fused bicyclic C 8-10 cycloalkyl, saturated or unsaturated fused bicyclic 8-10 membered-heterocyclyl, C 6-10 aryl and 5-10 membered heteroaryl and may be optionally substituted; and Z an ester, carbamate, phosphate, sulfate or prodrug thereof as defined below or Z 2 is selected from H, OH, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, (CH 2 ) m OC 1-6 alkyl, optionally substituted (CH 2 ) m SC 1-6 alkyl, optionally substituted (CH 2 ) m S(═O)C 1-6 alkyl, halo, optionally substituted haloC 1-3 alkyl, CN, optionally substituted (CH 2 ) m NR a R b , optionally substituted (CH 2 ) p -4-6-membered heterocycylic ring, optionally substituted (CH 2 ) p -spiro-bicyclic-7-11-membered heterocycylic ring and optionally substituted where p is an integer selected from 0, 1, 2 and 3 and represents an optionally substituted 4-6 membered heterocyclic ring or an optionally substituted spiro bicyclic 7-11-membered heterocyclic ring; and Alk is optionally substituted C with the proviso that at least one of Z an ester, carbamate, phosphate, sulfate or prodrug thereof wherein q is an integer selected from 0, 1, 2 and 3; R R t is an integer selected from 1, 2, 3, 4, 5 and 6; or R * represents the point of attachment to Ring A or Ring B respectively; and further wherein each (CH