Patent ID: 8012979
Filing Date: 2011-09-06
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: R R R R R Ar is an aryl or heteroaryl ring optionally substituted with 1, 2 or 3 groups independently selected from —(C X is selected from a single bond, O, NR Y is selected from heterocycloalkyl, O-heterocycloalkyl, O—(CH Z is selected from C(O)N(R R R R R or R R R R a is selected from 0, 1, 2, 3, 4, 5 and 6; d, e and h are independently selected from 0, 1, 2 and 3; b, f, g and j are independently selected from 0, 1 and 2; heterocycloalkyl is a C-linked 3 to 7 membered non-aromatic cyclic ring, containing from 1 to 2 NR heteroaryl is a 5, 6, 9 or 10 membered aromatic ring, containing from 1 to 2 N atoms and, optionally, an NR cycloalkyl is a non-aromatic carbocyclic ring containing the requisite number of carbon atoms, optionally containing, where possible, up to 3 double bonds; which, unless otherwise stated, may be optionally substituted with 1 to 3 substituents independently selected from (C aryl is an aromatic ring containing 6 or 10 carbon atoms; which unless otherwise stated, may be optionally substituted with 1 to 3 substituents independently selected from (C R R R R R or a pharmaceutically acceptable salt or N-oxide thereof.