Patent ID: 6596739
Filing Date: 2003-07-22
Classification: C07D

Abstract:
A compound having all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, having the formula: wherein:a) R1 is selected from the group consisting of alkyl, aryl, and heterocycle; b) R2 is selected from the group consisting of hydrogen, alkyl, aryl, and heterocycle; c) each R3 is independently selected from the group consisting of hydrogen, halogen, alkyl, aryl, heterocycle, nitro, cyano, when R3 is alkyl, aryl, or heterocycle R3 can be substituted with hydroxy, thio, amino, amide, formyl, carboxy, and carboxamide; two R3 units may be taken together to form a fused ring said ring optionally comprising a heteroatom; d) R4 is selected from the group consisting of hydrogen, halogen, alkyl, aryl, heterocycle, an alkyl or aryl ester, and an alkyl or aryl amide; e) R7 is selected from the group consisting of hydrogen, alkyl, aryl, and heterocycle; f) R8 is selected from the group consisting of hydrogen, alkyl, alkylacyl, arylacyl, alkylsulfonyl, and arylsulfonyl; g) A is aryl or heterocycle.