Patent ID: 8871955
Filing Date: 2014-10-28
Classification: C07D

Abstract:
1. A process for the purification of a crude mixture of a pharmaceutically acceptable salt of escitalopram comprising: a. dissolving said salt in water; b. adjusting the pH of the aqueous layer to 7.0-7.7 with a base; c. extracting said escitalopram with an organic solvent; d. isolating organic and aqueous layers; e. repeating steps (b)-(d) on the isolated aqueous layer of step (d); f. combining organic extract layers and optionally washing organic layer with water; and g. isolating and optionally drying the organic layer of step (f) and removing the organic solvent, wherein the organic solvent is not miscible with water and wherein the process involves the removal of diamine impurities from the crude mixture.