Patent ID: 6235769
Filing Date: 2001-05-22
Classification: A61K

Abstract:
A method of preventing or treating a neurodegenerative disorder in a mammal, wherein said neurodegenerative disorder is caused by an aberration in cell survival, said method comprising the step of administering a pharmaceutical composition comprising one or more compounds to said mammal, wherein said compound is a modulator of a C-RET receptor protein tyrosine kinase, and wherein said compound is an indolinone compound of Formula I: ##STR11##wherein,R.sub.1 is hydrogen or alkyl;R.sub.2 is oxygen or sulfur;R.sub.3 is hydrogen;R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, CONRR', and (CH.sub.2).sub.n ONRR';A is a five-membered heteroaryl ring selected from the group consisting of thiophene, pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, oxazole, isoxazole, thiazole, isothiazole, 2-sulfonylfuran, 4-alkylfuran, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, 1,2,3,4,-oxatriazole, 1,2,3,5-oxatriazole, 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole, 1,3,4-thiadaizole, 1,2,3,4-thiatriazole, 1,2,3,5-thiatriazole, and tetrazole, wherein said five-membered ring is optionally substituted at one or more positions with one or more substituents independently selected from the group consisting of alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, CONRR', and (CH.sub.2).sub.n ONRR';n is 0-3;R is selected from the group consisting of hydrogen, alkyl, and aryl; andR' is selected from the group consisting of hydrogen, alkyl, and aryl, wherein said alkyl is optionally substituted with a six-membered heteroaliphatic ring, and wherein said six-membered ring is optionally substituted at one or more positions with substituents selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, NO.sub.2, and (CH.sub.2).sub.n CO.sub.2 R.