Patent ID: 9017694
Filing Date: 2015-04-28
Classification: A61K,C07K,C12N

Abstract:
1. A reassortant influenza virus comprising at least 6 internal genome segments from one or more master donor viruses and a first genome segment encoding a hemagglutinin polypeptide comprising an amino acid sequence selected from the group consisting of: (a) SEQ ID NO:1; (b) a modified SEQ ID NO:1, wherein the amino acid at position 125 is substituted with an aspartic acid (D) or a glutamic acid (E); (c) a modified SEQ ID NO:1, wherein the amino acid at position 127 is substituted with a glutamic acid (E); and (d) a modified SEQ ID NO:1, wherein the amino acid at position 125 is substituted with an aspartic acid (D) or a glutamic acid (E) and the amino acid at position 127 is substituted with a glutamic acid (E); wherein the six internal genome segments and the hemagglutinin encoding genome segment are from different influenza viruses.