Patent ID: 6274587
Filing Date: 2001-08-14
Classification: A61P,C07D

Abstract:
A compound having formula I: ##STR27##or a pharmaceutically acceptable salt thereof wherein,n is an integer 0-1;m is an integer 1-2;provided that when m is 2, n is 0;R.sup.1 is selected from the group consisting of aryl and heterocycle;Q is selected from the group consisting of C(O), S(O), and S((O).sub.2 ;V is selected from the group consisting of C(R.sup.6)(R.sup.7), O, S, and NR.sup.2, wherein R.sup.2 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkynyl, aryl, arylalkoxy, arylalkenyl, arylalkyl, cyano, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, --NR.sup.4 R.sup.5, and (NR.sup.4 R.sup.5)alkyl wherein R.sup.4 and R.sup.5 are independently selected from the group consisting of hydrogen and lower alkyl;R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylthio, alkynyl, aryl, arylalkoxy, arylalkenyl, arylalkyl, carboxy, cyano, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, halogen, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, oxo, --NR.sup.4 R.sup.5, and (NR.sup.4 R.sup.5)alkyl;X is selected from the group consisting of N and CR.sup.3, wherein R.sup.3 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylthio, alkynyl, aryl, arylalkoxy, arylalkenyl, arylalkyl, carboxy, cyano, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, halogen, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, --NR.sup.4 R.sup.5, and (NR.sup.4 R.sup.5)alkyl;A and B are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylthio, alkynyl, aryl, arylalkoxy, arylalkenyl, arylalkyl, carboxy, cyano, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, halogen, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, --NR.sup.4 R.sup.5, and (NR.sup.4 R.sup.5)alkyl; andD and E are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylthio, alkynyl, aryl, arylalkoxy, arylalkenyl, arylalkyl, carboxy, cyano, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, halogen, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, oxo, --NR.sup.4 R.sup.5, and (NR.sup.4 R.sup.5)alkyl.