Patent ID: 6297231
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound represented by the formula I: ##STR54##or a pharmaceutically acceptable salt or hydrate thereof, wherein:B is selected from a group consisting of H, CN, ##STR55##straight or branch chain, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl and C.sub.1-6 -alkyl-X--C.sub.1-6 alkyl, wherein X is O, S, NH, or N(C.sub.1-6 alkyl), and wherein said alkyl and alkenyl are optionally substituted with 1 to 3 groups selected from the group consisting of ##STR56##and R.sup.2,wherein X is selected from the group consisting of O and NH,R.sup.3 is selected from the group consisting of amino and a heterocyclic group, said amino group can be substituted with ##STR57##C.sub.1-6 alkyl, aryl, hydroxy(C.sub.1-6)alkyl, and carbamoyloxy(C.sub.1-6)alkyl, said heterocyclic group is selected from ##STR58##R.sup.4 and R.sup.5 independently are selected from the group consisting of H, hydroxy(C.sub.1-6)alkyl, CN, amino, carbamoyl, carbamoyl(C.sub.1-6)alkyl, cyano(C.sub.1-6)alkyl, mono- or di-(C.sub.1-6)alkylcarbamoyl, carbamoyloxy, ureido, amino(C.sub.1-6)alkyl, carbamoyloxy(C.sub.1-6)alkyl, mono- or di-(C.sub.1-6)alkylcarbamoyl-(C.sub.1-6)alkyl, ureido(C.sub.1-6)alkyl, ##STR59##and ##STR60##wherein ##STR61##is a 3 to 6 membered heterocyclic ring which can contain additional hetero atoms,R.sup.2 is selected from the group consisting of hydroxy(C.sub.1-6)alkyl, carbamoyloxy, OH, NR.sup.6 SO.sub.2 R.sup.6, and N(R.sup.6).sub.2,R.sup.6 is selected from the group consisting of hydrogen and C1-6 alkyl,R.sup.20 and R.sup.21 are independently selected from the group consisting of H, C.sub.1-5 alkyl, C.sub.3-5 alkenyl, aralkyl group having 1 to 3 carbon atoms in its alkyl moiety, a substituted C.sub.1-5 alkyl, and pyridyl, or R.sup.20 and R.sup.21 taken together are selected from the goup consisting of an alkylene chain, and a alkylene chain linked via a C.sub.2 -C.sub.3 alkyl-substituted nitrogen atom to form, together with the adjacent nitrogen atom, a 3 to 7 membered cyclic amino group andR.sup.1 is selected from the group consisting of H and C.sub.1-6 alkyl.