Patent ID: 7771958
Filing Date: 2010-08-10
Classification: A61K,C07K

Abstract:
1. A method for predicting a response to epidermal growth factor receptor-directed therapy in a human subject, the method comprising the step of assaying a tumor sample from a candidate human subject for epidermal growth factor receptor-directed therapy with a plurality of reagents that detect expression and/or activation of predictive biomarkers for cancer; detecting expression of said plurality of predictive biomarkers to produce a pattern of expression and/or activation of a least two of said predictive biomarkers, and predicting a response to an epidermal growth factor receptor-directed therapy using the detected pattern of expression and/or activation of at least two predictive biomarkers, wherein the predictive biomarkers are selected from the group consisting of a growth factor receptor and a growth factor receptor-related downstream signaling molecule; and wherein the growth factor receptor is HER-1 (EGFR) and/or HER-3, and the growth factor receptor-related downstream signaling molecule is pERK.