Patent ID: 7179617
Filing Date: 2007-02-20
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A cell-free, in vitro method of forming a convalent conjugate of a Factor IX peptide, said peptide having the formula: wherein AA is a terminal or internal amino acid residue of said peptide; X X X said method comprising: (a) removing X (b) contacting said truncated glycan with at least one glycosyltransferase and at least one modified sugar donor under conditions suitable for said at least one glycosyltransferase to transfer a modified sugar moiety of said at least one modified sugar donor to said truncated glycan, wherein said modified sugar moiety comprises at least one modifying group which is a water-soluble polymer, thereby forming said covalent conjugate of said Factor IX peptide.