Patent ID: 6107342
Filing Date: 2000-08-22
Classification: A61P,C07B,C07C

Abstract:
A process for the preparation of a compound of formula ##STR35## wherein R.sup.1 is hydroxy, lower alkoxy, lower alkenyloxy, benzyloxy, hydrogen, deuterium or tritium,R.sup.11 is hydrogen, deuterium, tritium, hydroxy or amino, andR.sup.2 is hydrogen or tritium, orR.sup.1 and R.sup.2 form a bond,which process comprises:a) reacting a compound of formula ##STR36## with a reducing agent, to obtain a compound of formula VII and a compound of formula X ##STR37## wherein R'"" and R"" are each independently selected from benzyl or lower alkyl, and then,b) reacting with a reducing agent to reduce the azide group, andc) hydrolyzing the ester groups,to obtain a compound of formula I.