Patent ID: 6573404
Filing Date: 2003-06-03
Classification: C04B,C07C,C07D,Y02W

Abstract:
A process for the preparation of N-diaminomethylene-2-methyl-4,5-di(methylsulfonyl)benzamide, whereina) 2-bromo-5-chlorotoluene is reacted with a secondary or tertiary organolithium compound and CO2 to produce 4-chloro-2-methylbenzoic acid, b) 4-chloro-2-methylbenzoic acid is reacted with chlorosulfonic acid, sodium sulfite and methyl iodide to produce 2-methyl-4-chloro-5-methylsulfonylbenzoic acid, c) 2-methyl-4-chloro-5-methylsulfonylbenzoic acid is reacted with sodium methylthiolate and then oxidized with an oxidizing agent to produce 2-methyl-4,5-di(methylsulfonyl)benzoic acid, d) 2-methyl-4,5-di(methylsulfonyl)benzoic acid is reacted with thionyl chloride to produce 2-methyl-4,5-di(methylsulfonyl)benzoyl chloride, and e) 2-methyl-4,5-di(methylsulfonyl)benzoyl chloride is reacted with guanidinium chloride to produce N-diaminomethylene-2-methyl-4,5-di(methylsulfonyl)benzamide.