Patent ID: 6656504
Filing Date: 2003-12-02
Classification: A61K,A61P

Abstract:
A nanoparticulate composition comprising:(a) amorphous cyclosporin particles; and (b) at least one non-crosslinked surface stabilizer adsorbed on the surface of the cyclosporin particles, wherein: (i) the cyclosporin particles have an effective average particle size of less than about 2000 nm, and (ii) the cyclosporin and at least one surface stabilizer are present in a ratio of about 10:1 to about 1.5:1 (w/w), cyclosporin to surface stabilizer and (iii) the nanoparticulate composition does no contain an alcohol solubilizing agent and (iv) wherein the nanoparticulate composition does not contain solvent residues resulting from solvent extraction, solvent precipitation, or solvent-mediated hydrosol formation.