Patent ID: 8039594
Filing Date: 2011-10-18
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polypeptide that specifically binds an exposed epitope shared by p53 mutant proteins and not by wild type p53 protein, wherein said polypeptide has affinity for said epitope of less than 25 nanomolar and wherein said polypeptide comprises a heavy chain variable domain comprising a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO: 5, a CDR2 comprising the amino acid sequence of SEQ ID NO: 6, a CDR3 comprising the amino acid sequence of SEQ ID NO: 7 and a light chain variable region comprising a CDR1 comprising the amino acid sequence of SEQ ID NO: 39, a CDR2 comprising the amino acid sequence of SEQ ID NO: 40 and a CDR3 comprising the amino acid sequence of SEQ ID NO: 41.