Patent ID: 6749864
Filing Date: 2004-06-15
Classification: A61K,C07D,Y10S

Abstract:
A stabilized pharmaceutical composition for the inhibition of gastric acid secretion, comprising an effective amount of a benzimidazole compound of the formula (I) wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy hydroxyalkyl, trifluoromethyl, acyl carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl; R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl; R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy; R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy; and m is an integer from 0 to 4, or a derivative thereof or salt thereof having a gastric acid secretion inhibitory property, and a basic inorganic salt stabilizing agent, wherein the stabilizing agent is a basic inorganic salt of at least one selected from the group consisting of magnesium, calcium, potassium, and sodium and the stabilizing agent is homogenously admixed with the compound of the formula (I) in an effective amount to provide stability to the compound of the formula (I).