Patent ID: 7598266
Filing Date: 2009-10-06
Classification: A61P,C07D

Abstract:
1. A compound of the structural Formula VIII: or a pharmaceutically acceptable salt thereof, wherein: (a) R26, R27, R28 and R31 are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (b) X is selected from the group consisting of a O, S, S(O) (c) U is an aliphatic linker of C (d) Y is selected from the group consisting of C, O, S, NH, and a single bond; (e) E is C(R3)(R4)A and wherein (f) B is selected from the group consisting of N, S and O; (g) Z is selected from the group consisting of N and C; (h) R8 is selected from the group consisting of hydrogen, C (i) R9 is selected from the group consisting of hydrogen, C (j) R10, R11 are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (k) R30 is selected from the group consisting of C (l) R32 is selected from the group consisting of hydrogen, halo, C