Patent ID: 7785577
Filing Date: 2010-08-31
Classification: A61K,A61P

Abstract:
1. Method for the cosmetic treatment of canities comprising the administration to a patient in need thereof of an effective amount of a peptide of formula (I) or its peptidic conjugate of formula (II) wherein: A represents a radical corresponding to a monocarboxylic acid of general formula (III) wherein R represents a linear or branched aliphatic C lipoic acid or its reduced form dihydrolipoic acid, N-lipoyl-lysine or phenylbutyric acid W represents His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg, Nle-Ala-Arg, Nle-Ala-DTrp or a bond in the case of peptidic conjugates of formula II Z represents NH with the exception of a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z represents Trp NH in the form of enantiomers or diastereoisomers as well as mixtures thereof, including racemic mixtures, and wherein the peptide of formula (I) and peptidic conjugate of formula (II) each contains at most six amino acids.