Patent ID: 6593362
Filing Date: 2003-07-15
Classification: A61K,A61Q,Y02A

Abstract:
A method of treatment or prophylaxis of a non-neurologic ischemic injury or ischemia/reperfusion injury in a mammal is need thereof, comprising administering to said mammal an effective amount of a compound of Formula I, Where n in Cn is 0 or 1; The dashed bond symbol represents an optional bond; X and Y may independently be N, NH, O, S, or a direct bond; R1 is the same as or different than R2, and can either be one or more C1-C6 branched or straight chain alkyl or alkenyl groups; one or more C1-C3 branched or straight chain alkyl groups substituted by one or more Q groups or one or more Q groups, where Q, which is optionally saturated, partially saturated, or aromatic, is a mono-, bi-, or tricyclic, carbo- or heterocyclic ring, wherein each ring may be optionally substituted in one to five positions with halo, hydroxyl, nitro, trifluoromethyl, acetyl, aminocarbonyl, methylsulfonyl, oxo, cyano, carboxy, C1-C6 straight or branched chain alkyl or alkenyl, C1-C4 alkoxy, C1-C4 alkenyloxy, phenoxy, benzyloxy, amino, or a combination thereof, and wherein the individual ring sizes are 5-6 members, and wherein each heterocyclic ring contains 1-6 heteroatoms selected from the group consisting of O, N, S, or a combination thereof; and R3 may be one to three substitutents chosen from the group consisting of halo, hydroxyl, nitro, trifluoromethyl, C1-C4 straight or branched chain alkyl or alkenyl, C1-C4 alkoxy, C1-C4 alkenyloxy, phenoxy, benzyloxy, amino, Q as defined above, or a combination thereof; wherein said ischemic injury or ischemia/reperfusion injury is selected from the group consisting of mesenteric infarction, bowel ischemia, hepatic infarction, renal infarction, splenic infarction, and ischemic heart disease.