Patent ID: 8076459
Filing Date: 2011-12-13
Classification: A61K,A61P,C07K

Abstract:
1. A cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain wherein said first domain is deimmunized and comprises a CDR-H1 region as depicted in SEQ ID NO.:88, a CDR-H2 region as depicted in SEQ ID NO.:90 or SEQ ID NO.:92 and a CDR-H3 region, said CDR-H3 region comprising an amino acid sequence as depicted in SEQ ID NO.: 96, 108, 119, 120, 121, 122, 123, 124, 125, 126, or 127; and wherein said first domain further comprises in its framework H1 the sequence VKK and wherein the transition sequence between framework H1 and CDRH1 region comprises the sequence Ala-Ser-Gly-Tyr-Thr-Phe (ASGYTF; SEQ ID NO.: 233); and wherein said construct comprises a CDR-L1 as depicted in SEQ ID NO.: 98 or SEQ ID NO.:100, a CDR-L2 as depicted in SEQ ID NO.: 102, and a CDR-L3 as depicted in SEQ ID NO.:104 and wherein said Ig-derived second binding domain is a scFv.