Patent ID: 6169072
Filing Date: 2001-01-02
Classification: A61K,A61P,C07K

Abstract:
A method for the prophylaxis or treatment of cardiac infarct, arterial sclerosis, apoplexy, angina pectoris, osteoporosis, angiogenesis, or restenosis after angioplasty, comprising administering a cyclopeptide compound of formula I cyclo-(Arg-B-Asp-D-E) wherein B is Gly, Ala, or --NH--Q--CO; D is Nal, Phe, 4-Hal-Phe, or Phg; E is Gly, Ala, Lys, Lys(Ac), Lys(AcNH.sub.2), or Lys(AcSH); Hal is F, Cl, Br, or I; Q is alkylene having 1-6 C atoms; and Ac is alkanoyl having 1-10 C atoms, or a physiologically acceptable salt thereof, with the proviso that said compound is not cyclo-(Arg-Gly-Asp-Phe-Val) or cyclo-(Arg-Ala-Asp-Phe-Val), in which optically active amino acids can be either the D or L form.