Patent ID: 8580807
Filing Date: 2013-11-12
Classification: A61P,C07D

Abstract:
1. A compound having the formula: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: A is aryl or -5- or 6-membered heteroaryl, wherein said aryl group or said -5- or 6-membered heteroaryl group can be optionally substituted with up to 4 groups, which can be the same or different, and are selected from alkyl, aryl, alkenyl, cycloalkyl, cycloalkenyl, haloalkyl, hydroxyalkyl, halo, —OH, —O-haloalkyl, —O-alkyl, —O-alkyl-OH, —O-alkyl-O-alkyl, —O-aryl, -alkylene-O-alkyl, —CN, —N(R B is aryl or heteroaryl, wherein said aryl group or said heteroaryl group can be the same or different, and are selected from alkyl, aryl, alkenyl, cycloalkyl, cycloalkenyl, haloalkyl, hydroxyalkyl, heteroaryl, halo, —OH, —O-haloalkyl, —O-alkyl, —O-aryl, -alkylene-O-alkyl, -alkylene-S(O) W is —C(O)O—, alkylene, —C(O)—, —C(O)—O—, —S(O) X is —C(R Y is a bond, alkylene, -(alkylene) Z is C(R each occurrence of R each occurrence of R each occurrence of R R each occurrence of R each occurrence of R each occurrence of R R R R R R each occurrence of R each occurrence of m is independently 1 or 2; each occurrence of n is independently 0, 1 or 2, such that the sum of n and m is an integer ranging from 0 to 4; p is an integer ranging from 0 to 4; q is an integer ranging from 0 to 4; and each occurrence of t is independently 0 or 1, such that (i) at least one of R