Patent ID: 6649596
Filing Date: 2003-11-18
Classification: A61K,C12N

Abstract:
A method of inhibiting vascular endothelial growth factor in tumor cells comprising the step of locally administering to said tumor cells, a therapeutically effective amount of a synthetic oligonucleotide complementary to a human vascular endothelial growth factor target nucleic acid, whereby expression of said vascular endothelial growth factor is inhibited,the oligonucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, and SEQ ID NO:16.