Patent ID: 7682790
Filing Date: 2010-03-23
Classification: C07C,C07F,C12N

Abstract:
1. A method of stabilizing nucleic acids in a biological sample, the method comprising: mixing a storage stabilization composition with a solution containing the nucleic acids, wherein the composition comprises a cationic compound of the general formula wherein Y represents nitrogen or phosphorus; R X at least one proton donor wherein the proton donor is present in the composition in a concentration of above 50 mM to saturation and wherein the proton donor is selected from the group consisting of saturated aliphatic monocarboxylic acids, unsaturated alkenyl-carboxylic acids, saturated and/or unsaturated aliphatic C stabilizing the nucleic acids, wherein the nucleic acids are stabilized by forming an ionic complex with the cationic compound; optionally separating the insoluble ionic complex from the solution; and optionally releasing the nucleic acids from the insoluble ionic complex.