Patent ID: 6818623
Filing Date: 2004-11-16
Classification: A61K,A61P,C07K

Abstract:
A composition comprising(a) a hedgehog conjugate, comprising from 1 to 4 moieties covalently bound to a protein comprising a hedgehog N-terminal domain; wherein each moiety is:i) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or of amino acids which form transmembrane helices and are positively charged, ii) an aliphatic, saturated or unsaturated hydrocarbon residue with a chain length of 8 to 24 C atoms and with a hydrophobic character, or iii) a hydrophobic thio group and (b) a bone growth factor selected from a bone morphogenetic protein, a parathyroid hormone, an insulin-like growth factor, or a transforming growth factor.