Patent ID: 6103900
Filing Date: 2000-08-15
Classification: C07D

Abstract:
A compound of the formula ##STR35## wherein A and R.sub.1 together with the carbons to which they are attached form pyrimidinyl which may be substituted by R.sub.5 which is hydrogen, C.sub.1 -C.sub.6 alkyl, fluoro, chloro, bromo, hydroxy, amino, O(C.sub.1 -C.sub.6 alkyl), NH(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.6 alkyl)(C.sub.1 -C.sub.6 alkyl), SH, S(O).sub.n (C.sub.1 -C.sub.6 alkyl) wherein n=0, 1 or 2, wherein said C.sub.1 -C.sub.6 alkyl may contain from one to two double or triple bonds and may be substituted by from 1 to 3 substituents R.sub.6 which is hydroxy., amino, C.sub.1 -C.sub.3 alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NH(C.dbd.O)CH.sub.3, fluoro, chloro, bromo or C.sub.1 -C.sub.3 thioalkyl.R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy, amino, O(C.sub.1 -C.sub.6 alkyl), NH(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.6 alkyl)(C.sub.1 -C.sub.6 alkyl), SH, S(O).sub.n (C.sub.1 -C.sub.6 alkyl) wherein n=0, 1, or 2, cyano, hydroxy, carboxy, or amido, wherein said alkyls may be substituted by one to three of hydroxy, amino, carboxy, amido, NH(C.dbd.O)(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.6 alkyl)(C.sub.1 -C.sub.6 alkyl), (C.dbd.O)O(C.sub.1 -C.sub.6 alkyl), C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 thioalkyl, fluoro, bromo, chloro, iodo, cyano or nitro;R.sub.3 is phenyl, naphthyl, 3 to 8-membered cycloalkyl or 9 to 12 membered bicycloalkyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, trifluoromrethyl, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, or one of cyano, nitro, amino, NH(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.4 alkyl)(C.sub.1 -C.sub.2 alkyl), COO(C.sub.1 -C.sub.4 alkyl), CO(C.sub.1 -C.sub.4 alkyl), SO.sub.2 NH(C.sub.1 -C.sub.4 alkyl), SO.sub.2 N(C.sub.1 -C.sub.4 alkyl)(C.sub.1 -C.sub.2 alkyl), SO.sub.2 NH.sub.2, NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl), S(C.sub.1 -C.sub.6 alkyl), SO.sub.2 (C.sub.1 -C.sub.6 alkyl), wherein said C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.6 alkyl may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; andR.sub.4 is 2,4,6-trichlorophenyl, 2,4,6-trimethlphenyl, 2,6-dichloro-4-trifluoromethylphenyl or 4-bromo-2,6-dimethylphenyl.