Patent ID: 6469174
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A method of making a compound having the structure or a pharmaceutically acceptable salt thereof, wherein:(a) R1, R2 and R3 are independently selected from the group consisting of (i) hydrogen, (ii) C1-5alkyl, (iii) C1-5alkylamino, (iv) diC1-5alkylamino, (v) a phenyl substituted with one or more of hydrogen, halogen, C1-5alkyl, and trihaloC1-5alkyl, and (vi) a phenylC1-5alkyl substituted with one or more of hydrogen, halogen, C1-5alkyl, and trihaloC1-5alkyl; (b) rings 1 and 2 are each independently substituted with one or more substituents selected from the group consisting of hydrogen, halogen, C1-5alkyl, and trihaloC1-5alkyl; (c) A and B are independently nitrogen or carbon, at least one of A and B being nitrogen; (d) D and E are nitrogen, with the proviso that (i) a double bond exists between the non-aryl carbon and either D or E, (ii) R2 is absent if the double bond exists between the non-aryl carbon and D, and (iii) R3 is absent if the double bond exists between the non-aryl carbon and E; and (e) the compound is neither 1,6-dihydro-7-(4-pyridyl)-8-(4-fluorophenyl)-2-phenylmethyl-pyrrolo[3,2-e]benzimidazole, nor 3,6-dihydro-8-(4-fluorophenyl)-3-(3-phenylpropyl)-7-(4-pyridyl)-pyrrolo[3,2-e]benzimidazole; said method comprising the step of contacting a first compound having the structure with a second compound having the structure under conditions permitting a Fischer indolization between the first and second compounds.