Patent ID: 6251916
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
An azacyclic ring system having the formula I ##STR21##including geometrical isomers, enantiomers, diastereomers, racemates, acid addition salts, and salts thereof with a pharmaceutically acceptable acid, whereinQ is ##STR22##X is --CH.sub.2 --, --NH--, --O-- or --S--;V, W, Y and Z independently are CH or N;n and m are 0 or one of n and m is 1 and the other is 0;R.sup.1 and R.sup.2 are at any position on the azacyclic ring, including the point of attachment of the heterocycle Q, and independently are hydrogen, --OH, halogen, --NH.sub.2, carboxy, straight or branched C.sub.1-10 -alkyl, C.sub.1-10 -alkenyl, or C.sub.1-10 -alkynyl, straight or branched C.sub.1-10 -alkoxy, or straight or branched C.sub.1-10 -alkyl substituted with --OH, --CN, --CHO, --OH, --OR.sup.3, --SR.sup.3, --NH.sub.2, --NHR.sup.3, --NR.sup.3 R.sup.4, --NO.sub.2, --SOR.sup.3, --SO.sub.2 R.sup.3, --COR.sup.3, --CO.sub.2 R.sup.3, --CONH.sub.2, --CONHR.sup.3, --CONR.sup.3 R.sup.4, or --CH.dbd.NOR.sup.3 ; orR.sup.1 and R.sup.2 independently are phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl, each of which are unsubstituted or substituted with halogen, --CN, C.sub.1-10 -alkyl, C.sub.1-10 -alkoxy, or C.sub.1-10 -alkylthio;R is hydrogen, halogen, --CN, --CHO, --OH, --OR.sup.3, --SR.sup.3, --NH.sub.2, --NHR.sup.3, --NR.sup.3 R.sup.4, --NO.sub.2, --SOR.sup.3, --SO.sub.2 R.sup.3, --COR.sup.3, --CO.sub.2 R.sup.3, --CONH.sub.2, --CONHR.sup.3, --CONR.sup.3 R.sup.4, or --CH.dbd.NOR.sup.3 ; orR is phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl, each of which are unsubstituted or substituted with halogen, --CN, C.sub.1-15 -alkyl, C.sub.1-10 -alkoxy, or C.sub.1-10 -alkylthio; orR is a 5 or 6 membered saturated, partly saturated or aromatic heterocyclic ring containing one to three heteroatoms; andR.sup.3 and R.sup.4 independently are straight, branched, or cyclic C.sub.1-15 -alkyl, C.sub.2-15 -alkenyl, C.sub.2 -.sub.15 -alkynyl, or combinations thereof, or R.sup.3 and R.sup.4 independently are phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl groups, each of which are unsubstituted or substituted with H, halogen, --CN, C.sub.1-15 -alkyl, C.sub.1-10 -alkoxy, C.sub.1-10 -alkylthio, or aryl; orR.sup.3 and R.sup.4 independently are 5 or 6 membered saturated, partly saturated or aromatic heterocyclic rings containing one to three heteroatoms.