Patent ID: 9194862
Filing Date: 2015-11-24
Classification: C12Q,G01N

Abstract:
1. A method for increasing the susceptibility of a CD34+CD38+lin− cell to apoptosis comprising: (a) isolating CD34+CD38+lin− CML cells from the blood or bone marrow of a patient with chronic myeloid leukemia; and (b) contacting the isolated CD34+CD38+lin− CML cells with apopgossypol, wherein contact of the apogossypol with the CD34+CD38+lin− CML cells causes an increase in the expression of a short isoform of a myeloid cell leukemia sequence 1 transcript (Mcl-1) in the CML cells, and a lower ratio of the Mcl-1 long isoform to the Mcl-1 short isoform, thereby increasing the susceptibility of a CD34+CD38+lin− cell to apoptosis.