Patent ID: 6420366
Filing Date: 2002-07-16
Classification: A61K,C07D

Abstract:
A method of treating benign prostatic hyperplasia by selectively antagonizing &agr;1-adrenergic receptors in a mammal comprising administering to said mammal a compound having the structure of Formula I its pharmaceutically acceptable salts, enantiomers, diastereomers, or N-oxides, wherein Y is O or S; Q, Z and Zâ€² are independently CH; X is CH or N; m=0-3; n=0-4; R1, R2 are independently selected from H, F, Cl, Br, OCH3, OC2H5, OCH2CF3, SCF3, CH3, C2H5, CF3, isopropyloxy, and cyclopropyl; and R3, R4 and R5 are independently H, C1-3, alkyl, substituted or unsubstituted phenyl.