Patent ID: 6039971
Filing Date: 2000-03-21
Classification: A61K,A61L

Abstract:
A composition for a skin patch preparation comprising a synthetic water holding polymer gel prepared by reacting, in the presence of water and at a pH of 4.0 to 6.1, a water-aoluble polymer of an aliphatic carboxylic acid or a salt thereof in an amount of 1 to 30% by weight based on the total weight of the composition, with a sparingly soluble aluminum compound in an amount of 0.2 to 15% by weight in terms of aluminum based on the weight of said water-soluble polymer, a reaction accelerator consisting essentially of an organic acid containing a hydroxyl group in its molecule, said organic acid being selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, gluconic acid and salicylic acid, said organic acid being present in an amount effective to increase the reaction rate of said water-soluble polymer and said aluminum compound, and a reaction inhibitor consisting essentially of an ethylenediamine compound, said ethylenediamine compound being present in an amount effective for control of the rate of initiation of gelation.