Patent ID: 8043601
Filing Date: 2011-10-25
Classification: A61K,A61P,C07K

Abstract:
1. A cycloazapeptide of formula Z: wherein: each Q R R R R X is a 5 or 6-membered heterocycle or a linker comprising a hydrophilic moiety selected from the group consisting of hydroxyl, carbonyl, amide (—C(O)NH—), sulfonamide, sulfonate, phosphate, polar amino acid moiety, PEG moiety, sugar mimetic and sugar moiety, or a combination thereof; Y is a 5 or 6-membered heterocycle or a linker comprising a hydrophilic moiety selected from the group consisting of hydroxyl, carbonyl, sulfonamide, sulfonate, phosphate, polar amino acid moiety, PEG moiety, sugar mimetic and sugar moiety; where at least one of X and Y is a 5 or 6-membered heterocycle; and w is 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixture of stereoisomers thereof.