Patent ID: 8216578
Filing Date: 2012-07-10
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for delivering a therapeutic agent to a cancer cell that expresses oncostatin M receptor beta (OSM-R.beta) comprising administering a composition comprising an anti-OSM-R.beta antibody or an antigen-binding fragment thereof that specifically binds to OSM-R.beta, wherein the anti-OSM-R.beta antibody or fragment thereof comprises the three complementarity determining regions from the heavy chain and the three complementarity determining regions from the light chain of the monoclonal antibody produced by the hybridoma having ATCC No. PTA-6511, and wherein the anti-OSM-R.beta antibody is linked to the therapeutic agent, wherein the cancer cell is a cancer cell of an ovarian cancer, a renal cancer, a lung cancer, or a sarcoma.