Patent ID: 8278287
Filing Date: 2012-10-02
Classification: A61P,C12N

Abstract:
1. A double-stranded compound having the structure: 5′ (N) 3′ Z′—(N′) wherein each of N and N′ is a nucleotide which may be an unmodified or a modified ribonucleotide, or may be an unconventional nucleotide moiety; wherein each of (N) wherein Z and Z′ may be present or absent, but if present is independently 1-5 consecutive nucleotides covalently attached at the 3′ terminus of the strand in which it is present; wherein Z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′ terminus of (N′) wherein x=y=19; wherein (N) wherein (N′) wherein the sequence of (N)