Patent ID: 6624308
Filing Date: 2003-09-23
Classification: C07D

Abstract:
A method of producing a 2,4â€²-dipyridyl compound having the formula (II): wherein R3 and R4 each represents a hydrogen atom, comprisingreacting a 2-halopyridine compound having the formula (I): â€ƒwherein X represents a halogen atom and R3 and R4 are the same as defined above with 4-halopyridine using a nickel complex catalyst in the presence or absence of a tetraalkylammonium halide to cause a coupling reaction therebetween; and separating the 2,4â€²-dipyridyl compound by: dissolving a mixture of dipyridyl compound isomers containing a 2,4â€²-dipyridyl compound having the formula (II) in an organic solvent; followed by insolubilizing and adding a copper sulfate solution to remove byproducts as copper sulfate salts, wherein said byproducts include a 2,2â€²-dipyridyl compound and a 4,4â€²-dipyridyl compound.