Patent ID: 7153969
Filing Date: 2006-12-26
Classification: A61P,C07C,C07D

Abstract:
1. A process for the preparation of a compound having the formula: which comprises reacting 2-(thien-2-yl)ethylamine having the formula in the form of a base or a salt, with an (R)-sulphonyloxyacetic ester having the formula wherein R 1 is benzyl, C 1 –C 4 -alkyl optionally substituted by one or more halogens, or phenyl optionally substituted by nitro, one or more halogens or one or more C 1 –C 4 -alkyl groups, in the presence of a base, used alone or in aqueous solution and reacting the resulting compound of the formula with a formylation agent, and effecting cyclization in the presence of an acid to give the desired compound.