Patent ID: 6537805
Filing Date: 2003-03-25
Classification: A61K,A61P,C12N

Abstract:
A recombinant vector comprising:(a) at least one first transcription cassette containing a sequence coding for a recombinase, a minimal promoter MP functionally linked thereto, a transcription factor binding site and optionally a polyadenylation sequence, wherein the minimal promoter MP depends on the activation by one or several transcription factors, wherein the transcription factor binding site binds the transcription factor p53; (b) at least one second transcription cassette containing a suicide gene, a promoter P functionally linked thereto and optionally a polyadenylation sequence; (c) a 5â€² flanking sequence and/or a 3â€² flanking sequence, wherein the 5â€² and/or 3â€² flanking sequence contains a recombinase target sequence.