Patent ID: 8101720
Filing Date: 2012-01-24
Classification: A61P,C07K

Abstract:
1. A protein comprising an IgG2 Fc variant of a Fc IgG2 parent polypeptide, said parent polypeptide having the sequence of amino acids 106 to 326 of SEQ ID NO:2, wherein the amino acid modifications of said IgG2 variant consist of: a) substitution at positions 113-115 of SEQ ID NO:2 with Glu-Leu-Leu; b) an insertion of a Gly amino acid residue after position 115 of SEQ ID NO:2; c) a substitution at position 118 of SEQ ID NO:2 with an Asp amino acid residue; d) a substitution at position 206 of SEQ ID NO:2 with an Ala amino acid residue; and e) a substitution at position 211 of SEQ ID NO:2 with a Glu amino acid residue.