Patent ID: 7132544
Filing Date: 2006-11-07
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (I) wherein R R R where p is an integer from 0 to 9; X is selected from the group consisting of hydrogen, hydroxy, vinyl, substituted vinyl, (where one or more substituents are selected from fluorine or chlorine), ethynyl, substituted ethynyl (where the substituent is selected from fluorine or chlorine), C pharmaceutically acceptable salts thereof; comprising cyclizing a compound of formula (XI), wherein L 1 and L 2 are independently selected from the group consisting of C 1 –C 4 alkyl and C 1 –C 4 aralkyl; or L 1 together with L 2 is selected from the group consisting of —CH 2 —CH 2 — (optionally substituted with one to four C 1 –C 3 alkyl), and —CH 2 —CH 2 —CH 2 — (optionally substituted with one to six C 1 –C 3 alkyl), under acid conditions of pH less than about 7, to produce the corresponding compound of formula (XII); reacting the compound of formula (XII) with POBr 3 , PBr 5 , or a mixture of PBr 3 and Br 2 , to yield the corresponding compound of formula (XIII); displacing the bromine on the compound of formula (XIII) by reacting with a compound of formula (XIV), to produce the corresponding compound of formula (I).