Patent ID: 8609126
Filing Date: 2013-12-17
Classification: A61K,A61L,A61P

Abstract:
1. A method of manufacturing a composition comprising: combining at least one treatment agent selected for treating a post-myocardial infarction area of a heart with a precursor of a sustained-release carrier in a solvent to form a mixture; processing the mixture to form a sustained-release carrier loaded with the at least one treatment agent; adding the sustained-release carrier loaded with the at least one treatment agent to a first component solution of a two-component gel system; and combining the first component solution having the sustained-release carrier loaded with the at least one treatment agent therein and a second component solution of the two-component gel system in situ to form a gel scaffold to support a tissue within the post-myocardial infarction area of the heart by separately injecting the first component solution and the second component solution into the post-myocardial infarction area of the heart, and wherein the two-component gel system is selected from the group consisting of an alginate construct system, a fibrin glue system and a self-assembled peptide system.