Patent ID: 7494989
Filing Date: 2009-02-24
Classification: A61K,A61P,C07D

Abstract:
1. A pyridine compound of formula (1″), or a pharmaceutically acceptable salt thereof: wherein A′ represents a group of the following general formula (9): wherein R 16 , R 17 , R 18 , R 19 and R 20 may be the same or different from each other and each represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group or a lower alkylamino group, C′ and E′ may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group which may contain a hetero atom in the chain thereof, dimethoxymethyl group, cyano group, an aryl-lower alkyl group, a heteroaryl-lower alkyl group, a hydroxy-lower alkyl group, an amino-lower alkyl group, a halogeno-lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group or a group of the following general formula (3) or (4): wherein X 2 represents O, S or N—R 8 , n represents an integer of 1 to 6, K in general formula (3) represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, azido group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, G in the general formula (4) represents N or C—H, wherein R 6 to R 8 may be the same or different from each other, and each represents a hydrogen atom, a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 1 to 6 carbon atoms, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, an amino-lower alkyl group, an amino-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkenyl group, an aryl-lower alkyl group, an aryl-lower alkenyl group, a heteroaryl-lower alkyl group, a heteroaryl-lower alkenyl group, a cyano-lower alkyl group or a cyano-lower alkenyl group, and the chains may contain a hetero atom, or R 6 and R 7 may together form a ring which may contain a hetero atom, B′ represents a hydrogen atom only when Y′ represents the general formula (12) and R 26 is a substituted or unsubstituted aryl group, a carboxyl group only when Y′ represents the general formula (12) or Y′ and F′ together form the following general formula (12′-1), (12′-2), (12″-1) or (12″-2), or a group of the following general formula (10): wherein Z represents a nitrogen atom, an oxygen atom or a carbon atom, p represents an integer of 1 to 3, J is present only when Z is a nitrogen atom or a carbon atom and when present represents a hydrogen atom, a lower alkyl group which may contain a hetero atom in the group thereof, a hydroxy-lower alkyl group, an amino-lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aryl-lower alkyl group or a substituted or unsubstituted heteroaryl-lower alkyl group, F′ represents the following general formula (11): wherein R 21 , R 22 , R 23 , R 24 and R 25 may be the same or different from each other and each represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkylamino group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, X′ represents an oxygen atom or >NH, Y′ represents a saturated or unsaturated linear hydrocarbon group having 1 to 6 carbon atoms, which may contain a hetero atom in the group thereof, or a group of the following general formula (12): wherein R 26 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group and h represents an integer of 0 to 5, Y′ and F′ together form a group of the following general formula (12′-1), (12′-2), (12″-1) or (12″-2): wherein h represents an integer of 0 to 5, i represents an integer of 2 to 5, R 32 , R 33 , R 34 and R 35 may be the same or different from each other and each represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkylamino group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group.