Patent ID: 6130349
Filing Date: 2000-10-10
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
A method of selective alkylation of a substrate having an allyl group bearing a leaving group at the allylic position, said method comprisingreacting said substrate with an alkylating agent in the presence of a catalytic composition formed by contacting, in a suitable solvent, catalytic amounts of(i) a chiral ligand L.sup.1, said ligand comprising(a) an axially chiral 1,1'-binaphthyl system, said system substituted at its 2 position and at its 2' position with a group X selected from --O-- or --NR--, where R is hydrogen or lower alkyl, and, linked to each said group X,(b) a binding group Cy.sub.N comprising a heterocyclic group having a ring nitrogen atom effective to bind to a metal atom selected from the group consisting of molybdenum, tungsten, and chromium, wherein said heterocyclic group is optionally substituted with one or more groups selected from alkyl, alkenyl, aryl, aralkyl, alkoxy, aryloxy, acyl, acyloxy, amide, tertiary amine, nitro, or halogen, and may be fused to one or more additional rings; and(ii) a hexacoordinate complex of a metal selected from the group consisting of molybdenum (0), tungsten (0), and chromium (0), said hexacoordinate complex comprising ligands which are effective to form a stable complex with said metal atom and which are displaceable by ligand L.sup.1 under the conditions of said contacting,under conditions effective to produce an alkylated product which is enriched in one of the possible isomeric products of such alkylation.