Patent ID: 8075873
Filing Date: 2011-12-13
Classification: A61K,A61P

Abstract:
1. A dry powder inhalation composition prepared by a process comprising the steps of: (a) mixing an inert particulate carrier with a first portion of a first particulate inhalant medicament comprising an anti-inflammatory steroid to form a first mixture, wherein said particulate carrier has a volume median diameter (VMD) of from about 50 to about 250 μm, wherein the first portion of the first particulate inhalant medicament is sufficient to create a monolayer of the first particulate inhalant medicament on the particulate carrier; (b) mixing said first mixture with a second particulate inhalant medicament comprising a bronchodilator to form a second mixture; and (c) mixing said second mixture with a second portion of the first particulate inhalant medicament to form a dry powder inhalation composition, wherein, in the dry powder inhalation composition from step (c), the ratio by weight of the second particulate inhalant medicament to the carrier is less than the ratio by weight of the first particulate inhalant medicament to the carrier, and wherein the dry powder inhalation composition consists of said particulate carrier, said first particulate inhalant medicament and said second particulate inhalant medicament.