Patent ID: 7064189
Filing Date: 2006-06-20
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody or fragment thereof comprising amino acid residues 26–35, 50–66, 99–107, 157–170, 186–192, and 225–234 of SEQ ID NO:43, wherein said antibody or fragment thereof immunospecifically binds a TR4 protein selected from the group consisting of: (a) a polypeptide having the amino acid sequence of any one of amino acid residues 1 to 468 of SEQ ID NO:1, amino acid residues 24 to 468 of SEQ ID NO:1, amino acid residues 24 to 238 of SEQ ID NO:1, and amino acid residues 109 to 240 of SEQ ID NO:1; (b) a multimer of the polypeptide of (a); (c) the polypeptide of (a) expressed on the surface of a cell; and (d) the multimer of (b) expressed on the surface of a cell.