Patent ID: 6645990
Filing Date: 2003-11-11
Classification: A61P,C07D

Abstract:
A compound of formula VI wherein R15 is one or more substituents selected from H, optionally substituted 6-membered nitrogen-containing heterocyclyl, phenyl, C1-C3-alkyl, C1-C2-haloalkyl, C1-C4-hydroxyalkyl, amino, C1-C4-azidoalkyl, C1-C4-cyanoalkyl, C1-C4-aminoalkyl, halo, hydroxy, (optionally substituted 6-membered nitrogen-containingheterocyclyl)-C1-C4-alkyl, optionally substituted phenoxy-C1-C2-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylamino-C1-C4-alkyl, C1-C4-hydroxyalkylamino, amino-C1-C4-alkoxy-C1-C4-alkyl, optionally substituted 6-membered nitrogen-containing heterocyclyloxy, optionally substituted 6-membered nitrogen-containing heterocyclyl-C1-C4-alkoxy, C1-C4-alkylamino-C1-C4-alkoxy, optionally substituted phenoxy, C1-C4-alkoxycarbonyl, 6-membered heterocyclyl-C1-C4-alkylaminocarbonyl, 6-membered N-containing heterocyclylcarbonyl, C1-C4-alkylaminocarbonyl, C1-C4-alkylaminothiocarbonyl, C1-C4-alkylamino-C1-C4-alkylaminocarbonyl, aminocarbonyl, 6-membered N-containing heterocyclyl-sulfonyl-C1-C4-alkyl, 6-membered N-containing heterocyclyl-C1-C4-alkylamino, C1-C4-alkylamino, C1-C4-alkylamino-C1-C4-alkylamino-C1-C4-alkyl, and C1-C4-alkylamino-C1-C4-alkylamino; wherein R16 is selected from H, 6-membered nitrogen-containingheterocyclylcarbonyl, alkylaminocarbonyl, alkylaminomethyl, and 6-membered nitrogen-containing heterocyclylmethyl; and wherein R17 is selected from halo, C1-C6-alkyl, cycloalkylalkynyl, cycloalkyl, optionally substituted phenoxy, optionally substituted 6-membered nitrogen-containing heteroarylsulfonyl-C1-C4-alkyl, unsubstituted 6-membered nitrogen-containing heterocyclyl, phenyl optionally substituted with one or two substituents selected from halo, C1-C4-alkylamino, amino, nitro, C1-C4-alkoxy, C1-C2-haloalkyl, hydroxy, C1-C4-alkylthio, C1-C4-alkylcarbonylamino, (optionally substituted phenyl)sulfonylamino, cyano, C1-C2-haloalkoxy, 5- or 6-membered N-containing heterocyclyl, aminosulfonyl, (6-membered N-containing heterocyclyl)sulfonyl, C1-C2-haloalkylcarbonylaminosulfonyl and (optionally substituted phenyl)aminosulfonyl, and 6-membered nitrogen-containing heterocyclyl substituted with one or more substituents independently selected from pyridyl, phenyl, C1-C4 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy, amino, halo, piperidinyl, morpholinyl, C1-C2 alkylpiperazinyl, C1-C3 alkylaminothiocarbonyl, N,N-di-C1-C2alkylamino-C1-C4-alkylenyl, Nâ€”C1-C2alkylamino-C1-C4-alkylenyl, morpholinyl-C1-C4-alkylenylaminocarbonyl, aminocarbonyl, C1-C2-haloalkylcarbonylamino, morpholinyl-C1-C4-alkylenylamino, N,N-di-C1-C2alkylamino and N,N-di-C1-C2alkylamino-C1-C4-alkylenylamino; and pharmaceutically acceptable salts thereof; provided only one of R15 and R16 is H.