Patent ID: 6126916
Filing Date: 2000-10-03
Classification: A61K

Abstract:
A peptide comprising a radiometal-binding moiety, wherein said binding moiety comprises the structure: ##STR4## wherein R.sup.1, R.sup.2, and R.sup.3 independently are selected from the group consisting of H, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, and a protecting group that can be removed under the conditions of peptide synthesis, provided that at least one of R.sup.1, R.sup.2, R.sup.3 is H,R.sup.5, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 independently are selected from the group consisting of H, lower alkyl, substituted lower alkyl, aryl, and substituted aryl, and R.sup.8 and R.sup.9 together or R.sup.7 and R.sup.9 together may form a cycloalkyl or substituted cycloalkyl ring,R.sup.4 and R.sup.6 together form a direct bond or are independently selected from the group consisting of lower alkyl, substituted lower alkyl, aryl, and substituted aryl, andwherein NR.sup.10 is located at the N-terminus of said peptide, or is located on an amino acid side chain of said peptide.