Patent ID: 6797478
Filing Date: 2004-09-28
Classification: C07K

Abstract:
A method of determining the presence and extent of axonal damage in the head of a patient suspected of having suffered a neurologic trauma selected from acute cerebral vascular accident, primary hemorrhages, or primary vascular injuries, said method comprising the steps:(a) obtaining a sample of cerebrospinal fluid from said patient; (b) treating said sample of cerebrospinal fluid with at least one monoclonal antibody, said at least one monoclonal antibody having been raised against an axonally-derived tau protein of SEQ ID NO:1; (c) detecting the presence of said axonally-derived tau protein bound to said at least one monoclonal antibody; and (d) comparing the amount of said axonally-derived tau protein bound to said at least one monoclonal antibody in step (c) to control samples from the group representing a normal undamaged axon state and those representing an axonal damage state.