Patent ID: 9181231
Filing Date: 2015-11-10
Classification: A61K,A61P,C07D

Abstract:
1. A method for increasing lifetime of the red blood cells (RBCs) in need thereof comprising contacting blood with an effective amount of (1) a compound of formula (I), (I-II), (I-III), or (I-IV) or a pharmaceutically acceptable salt thereof; (2) a composition comprising a compound of formula (I), (I-II), (I-III), or (I-IV) or a salt thereof, and a carrier or (3) a pharmaceutically acceptable composition comprising a compound of formula (I), (I-II), (I-III), or (I-IV) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier: formula (I): wherein: m is an integer from 0 to 5; each R n is an integer from 1 to 3; each R B is aryl, monocyclic heteroaryl, cycloalkyl, heterocyclyl, C L is a linker selected from —SO each R X and Y are each independently selected from O, S, NR Z is O or S; each R R R formula (I-II): wherein: m is an integer from 0 to 5; each R n is an integer from 1 to 3; each R B is aryl, monocyclic heteroaryl, cycloalkyl, heterocyclyl, C L is a linker selected from —SO each R Z is O or S; each R R R formula (I-III): wherein: m is an integer from 0 to 5; each R each R each R R R formula (I-IV): wherein: m is an integer from 0 to 5; each R n is an integer from 0 to 3; each R B is aryl, monocyclic heteroaryl, cycloalkyl, heterocyclyl, C L is a linker selected from —SO each R X and Y are each independently selected from O, S, NR Z is O or S; each R R R