Patent ID: 7297941
Filing Date: 2007-11-20
Classification: G01N,H01J

Abstract:
1. A method of analyzing data from a mass spectrometer for a data dependent acquisition, comprising: obtaining a mass spectrum of a sample; creating an extracted ion chromatogram (XIC) for each m/z data point of the mass spectrum; correlating the XIC for each m/z data point of the mass spectrum scans to a model function corresponding substantially only to a front half of a peak to obtain a XIC correlation value; applying a weighting function to the XIC correlation value for each m/z data point to obtain a current weighted intensity; and reconstructing a weighted mass spectrum using the current weighted intensity for each m/z data point to make a real-time decision of when to make the data dependent acquisition such that the acquisition is made at a time corresponding to an apex of each m/z data point.