Patent ID: 7541022
Filing Date: 2009-06-02
Classification: A61K

Abstract:
1. A powder for use in a dry powder inhaler, the powder comprising: i) a fraction of fine particles prepared as a pre-blend mixture by co-micronising, co-milling or high energy mixing of a physiologically acceptable excipient and an additive, the mixture having a mean particle size of less than 35 μm and comprising composite excipient particles in which the additive material at least partially coats the surfaces of the excipient particles; ii) a fraction of coarse particles constituted of a physiologically acceptable carrier having a particle size of at least 90 μm, and having a fissured surface, the coarse carrier particles having: wherein the surfaces of the coarse carrier particles are at least partially coated with additive material; and iii) at least one active ingredient; said mixture (i) being composed of up to 99% by weight of particles of the excipient and at least 1% by weight of additive and the ratio between the fine excipient particles and the coarse carrier particles being between 1:99 and 40:60% by weight.