Patent ID: 8697856
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An isolated and purified hybrid nucleic acid molecule encoding a P. vivax circumsporozoite (CS) hybrid (PvCS-hybrid) protein comprising the N-terminal region of CS protein, the C-terminal region of CS protein, one or more copies of an AGDR epitope identified as amino acids 94-97 of SEQ ID NO: 13, one or more Type I repeats selected from the group identified as SEQ ID NO:3, 4, 5, 6, 7, 8 and 9, one or more Type II repeats selected from the group identified as SEQ ID NO: 10 and 14, and, one or more copies of a 12 amino acid insert identified as SEQ ID NO: 11 occurring after Type I repeats in P. vivax CS VK210.