Patent ID: 8658651
Filing Date: 2014-02-25
Classification: A61P,C07D

Abstract:
1. A compound of formula 1.0: or the pharmaceutically acceptable salts thereof, wherein: Y —CH═, —N═ and —CR z is 1 to 3; X Q is a substituent selected from the group consisting of: Each Q cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, wherein said substituted rings are substituted with 1 to 3 substituents independently selected from the group consisting of: halo and the R Q heterocycloalkyl and substituted heterocycloalkyl wherein said substituted rings are substituted with 1 to 3 substituents independently selected from the group consisting of: halo and the R Z Z m is 1 to 6; n is 1 to 6; p is 0 to 6; t is 0, 1, or 2; R wherein each R 10 is independently selected, wherein each a 10 is independently selected, (20) —C(O)—NR (21) —C(O)N(R (22) —C(O)—NR (23) —C(O)—NR (24) heterocycloalkenyl,  and (26) arylalkenyl-; R wherein each alkyl is independently selected, which each alkyl is independently selected, wherein each alkyl is independently selected, (22) —N(R (23) —C(O)-alkyl; and each R wherein said R wherein said R R R each R each R said R said R  (19) —NHR R R R R R R each R R each R each R each R R each R said R said R  and (19) —NHR R R Each R Each R R R