Patent ID: 7799767
Filing Date: 2010-09-21
Classification: A61F,A61K,A61L,A61P,B29C,B29L,Y10T

Abstract:
1. A cross-linked bioactive hydrogel matrix comprising a polyglycan covalently cross-linked to a tissue-derived or synthetic polypeptide, and further comprising at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof; wherein the polyglycan is a polysaccharide or a sulfated polysaccharide selected from the group consisting of dextran, oxidized dextran, heparan, heparin, hyaluronic acid, alginate, agarose, carageenan, amylopectin, amylose, glycogen, starch, cellulose, chitin, chitosan, heparan sulfate, chondroitin sulfate, dextran sulfate, dermatan sulfate, and keratan sulfate; wherein the polypeptide is selected from the group consisting of collagens, gelatins, keratin, decorin, aggrecan, laminin, nidogen, fibulin, and fibrillin; and wherein said cross-linked bioactive hydrogel matrix is a solid or semi-solid material at physiological temperature and physiological pH.