Patent ID: 7384751
Filing Date: 2008-06-10
Classification: G01N

Abstract:
1. A method for assessing skeletal muscle damage in a subject, comprising detecting the presence or absence or measuring the amount of: (a) a peptide fragment of a myofilament protein; or (b) a covalent or non-covalent complex of at least: in a biological sample obtained from a subject being assessed for skeletal muscle damage, said biological sample being selected from the group consisting of skeletal muscle tissue, a component of skeletal muscle tissue, blood, blood serum and urine, by incubating the biological sample with an antibody or antigen specific fragment thereof that specifically binds to the peptide fragment of a myofilament protein under conditions which allow the antibody or antigen specific fragment thereof to form a complex with the (a) peptide fragment of a myofilament protein; or (b) covalent or non-covalent complex of at least: and detecting or measuring the formed complex, wherein said peptide fragment of the myofilament protein or said peptide fragment of the covalent or non-covalent complex formation consists of: a skeletal troponin I peptide fragment, or a skeletal troponin T peptide fragment, and wherein the presence or amount of: (a) the peptide fragment of the myofilament protein; or (b) the covalent or non-covalent complex of at least: in the biological sample is associated with skeletal muscle damage.