Patent ID: 6908734
Filing Date: 2005-06-21
Classification: A61K,C07K

Abstract:
1. A method of inhibiting human immunodeficiency virus infection of a CD4+ cell which also carries a CCR5 receptor on its surface which comprises contacting the CD4+ cell with an amount of a binding-inhibiting compound effective to inhibit binding of human immunodeficiency virus to the CCR5 receptor so as to thereby inhibit human immunodeficiency virus infection of the CD4+ cell, said binding-inhibiting compound comprising the structure wherein T represents a threonine, S represents a serine, E represents a glutamic acid, each Y represents a tyrosine, D represents an aspartic acid, I represents an isoleucine, and N represents an asparagine; wherein α represents from 0 to 9 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO:1 beginning with the I at position 9 and extending therefrom in the amino terminal direction; wherein β represents from 0 to 13 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO:1 beginning with the P at position 19 and extending therefrom in the carboxy terminal direction; wherein θ represents an amino group or an acetylated amino group; wherein λ represents a carboxyl group or an amidated carboxyl group; wherein all of α, Y, D, I, N, Y, Y, T, S, E and β are joined together by peptide bonds; further provided that at least two of the tyrosines represented by Y in the YDINYYTSE portion of the structure of the compound are sulfated.