Patent ID: 6545034
Filing Date: 2003-04-08
Classification: A61K,G01N,Y10S

Abstract:
A method of the reducing the viability of human leukemia cells sensitive to a 1-(R) compound of formula (I): wherein R1 is lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl or benzyl, R2, R3, R4 and R5 are the same or different and are each hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, hydroxy, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, R7 is hydrogen, lower alkyl or lower alkenyl; X is oxy; Y is carbonyl or (C1-C3)alkyl(CO), wherein each alkyl is substituted with 0-2 (C1-C4) alkyl, and Z is hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino or phenylamino, or a pharmaceutically acceptable salt thereof, comprising administering an effective amount of the (R)-compound of formula (I) or the salt thereof to a human cancer patient afflicted with a leukemia and wherein R compound is substantially free of its S(+) stereoisomer.