Patent ID: 6051571
Filing Date: 2000-04-18
Classification: A61K,A61P,C07D

Abstract:
A method for treating a patient with a medical dysfunction or disease selected from the group consisting of an acute central nervous system disorder, an acute cardiovascular disorder, a neurodegenerative disease, an autoimmune disease and an inflammatory disease, said method comprising administering to said patient a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective medical dysfunction or disease-treating amount of a compound of formula I: ##STR16## wherein each R.sup.1 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkoxy, alkcycloalkyl, cycloalkyl, cycloalkenyl and halo;R.sup.2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkcycloalkyl, cycloalkyl and cycloalkenyl;R.sup.3 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkcycloalkyl, cycloalkyl and cycloalkenyl;each X is independently selected from the group consisting of --SO.sub.3 Y, --S(O)R.sup.4, --SO.sub.2 R.sup.5 and --SO.sub.2 NR.sup.6 R.sup.7 ;wherein Y is hydrogen or a pharmaceutically acceptable cation;R.sup.4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkcycloalkyl, cycloalkyl and cycloalkenyl;R.sup.5 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkcycloalkyl, cycloalkyl and cycloalkenyl;R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, alkaryl, aryl, alkcycloalkyl, cycloalkyl and cycloalkenyl; or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached can form a heterocyclic ring containing from 2 to 8 carbon atoms and optionally from 1 to 3 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;m is an integer from 1 to 3; and n is an integer from 0 to 2, provided that m+n=3; or pharmaceutically acceptable salts thereof.