Patent ID: 7130747
Filing Date: 2006-10-31
Classification: B01J,C40B,G01N

Abstract:
1. A process for high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data comprising: producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, wherein said selected polycrystalline macromolecule material comprises a protein; producing a second sample slurry of said selected polycrystalline macromolecule material, one or more ligands and said solvent; obtaining a high resolution powder diffraction pattern on each of said first sample slurry and said second sample slurry; and, comparing the high resolution powder diffraction pattern of said first sample slurry and the high resolution powder diffraction pattern of said second sample slurry whereby a change between the high resolution powder diffraction patterns of said first sample slurry and said second sample slurry indicates formation of a complex between said selected polycrystalline macromolecule material and at least one of said one or more ligands.