Patent ID: 9005696
Filing Date: 2015-04-14
Classification: A61C,A61F,A61L,B05D,C23C

Abstract:
1. A method of modifying a surface of bone-implantable medical device comprising the steps of: forming a plurality of holes in the surface of the medical device; first loading at least one of the plurality of holes with a first therapeutic agent; second loading at least another one of the plurality of holes with a second therapeutic agent that is different from the first therapeutic agent; first irradiating an exposed surface of the first therapeutic agent in the at least one loaded hole with a first ion beam to firm a first barrier layer at the exposed surface in the at least one loaded hole; and second irradiating an exposed surface of the second therapeutic agent in the at least another loaded hole with an ion beam to form a second barrier layer at the exposed surface in the at least another loaded hole, wherein the first barrier layer and the second barrier layer have different properties for controlling elution rate of the first and second therapeutic agents.