Patent ID: 6498242
Filing Date: 2002-12-24
Classification: C12N,C12P

Abstract:
An isolated nucleic acid fragment encoding adipic acid synthesizing enzymes selected from the group consisting of:(a) an isolated nucleic acid molecule as set forth in SEQ ID NO:27; (b) an isolated nucleic acid molecule that hybridizes with (a) under the following hybridization conditions: 0.1Ã—SSC, 0.1% SDS at 65Â° C.; and washed with 2Ã—SSC, 0.1% SDS followed by 0.1Ã—SSC, 0.1% SDS; or an isolated nucleic acid molecule that is completely complementary to (a) or (b); wherein the isolated nucleic acid molecule of parts (a) or (b) comprises open reading frames encoding each of the enzymes selected from the group consisting of: a cyclohexanone monooxygenase, a 6-aldehyde hexanoic dehydrogenase, a cyclohexanol dehydrogenase, a 6-hydroxy hexanoic acid dehydrogenase and a caprolactone hydrolase.