Patent ID: 6696424
Filing Date: 2004-02-24
Classification: A61K,C07C,C12N

Abstract:
A cationic lipid compound of the following formula whereinZ1, Z2, Z3 and Z4 are the same or different and are â€”Oâ€”C(O)â€” or â€”Oâ€”; R1 and R2 are the same or different and are H, C1 to C24 alkyl or C1 to C24 alkenyl; R3 and R4 are the same or different and are C1 to C24 alkyl or C1 to C24 alkenyl; R5, R6, R7 and R8 are the same or different and are H, C1 to C10 alkyl or C1 to C10 alkenyl; R9 is a linker; n and m are the same or different and are 1 to 8; and X and Y are the same or different and are non-toxic anions; provided that when R9 is a straight-chain alkylene having 3-6, 12, 16, 20, or 22 carbons, then all of R1, R2, R3, and R4 are not H, all of R5, R6, R7, and R8 are not methyl, m and n are not 1, and all of Z1, Z2, Z3, and Z4 are not O.