Patent ID: 8003784
Filing Date: 2011-08-23
Classification: C07D

Abstract:
1. A method for producing 6-(cyanopyrrole)-cyclocarbamate or cyclothiocarbamate compounds comprising: (a) reacting a cyanopyrrole with a coupling agent; (b) reacting the product of step (a) with an anthranilic ketone or nitro ketone thereof to form a cyanopyrrole substituted anthranilic ketone or nitro ketone thereof; (c) reacting the cyanopyrrole substituted anthranilic ketone or nitro ketone thereof with an organometallic nucleophile to form cyanopyrrole substituted anthranilic alcohol or nitro alcohol thereof; (d) optionally reducing the cyanopyrrole substituted anthranilic nitro alcohol to the cyanopyrrole substituted anthranilic alcohol; and (e) converting the cyanopyrrole substituted anthranilic alcohol to said 6-(cyanopyrrole)-cyclocarbamate or cyclothiocarbamate compound.