Patent ID: 6348599
Filing Date: 2002-02-19
Classification: G01N

Abstract:
A cyanine dye having the structure where the dotted lines represent the carbon atoms necessary for a one ring or a two or three fused ring system with 5 or 6 carbon atoms in each ring and R3, R4, R5 and R6 attached to the rings, X and Y are independently selected from O, S and CR28, where R8 is C1-C4 alkyl, n is 1, 2 or 3, at least one of R1, R2, R3, R4, R5, R6 and R7 contains a reactive group that can react with a functional group of a target molecule or contains a functional group that can react with a reactive group of a target molecule, at least one of R1, R2, R3, R4, R5, R6 and R7 contains one to five positively charged nitrogen or phosphorus or sulphur atoms, any remaining R3, R4, R5 and R6 is independently selected from H, SO3âˆ’, Cl, Br, OR9 and SR9, where R9 is C1-C10 alkyl or aryl or aralkyl, any remaining R1 and R2 is independently selected from C1-C10 alkyl or aryl or aralkyl either unsubstituted or substituted by SO3, any remaining R7 is selected from H and C1-C10 alkyl or aryl or aralkyl either unsubstituted or substituted by SO3, provided that at least two positively charged atoms selected from nitrogen and phosphorus and sulphur are present in the groups R1, R2, R3, R4, R5, R6 and R7, and provided that the first atom of R7 (through which it is linked to the rest of the molecule) is H or C.