Patent ID: 8236821
Filing Date: 2012-08-07
Classification: A61P,C07D,C07F

Abstract:
1. A compound of formula I or a stereoisomer or pharmaceutically acceptable salt thereof: wherein: L is C(═O) or SO X, X′, Y, and Y′ are independently selected from H, halogen, C wherein the aryl and heteroaryl groups are independently substituted with 0-2 groups selected from OH, OC 1-4 alkyl, OC 2-4 alkenyl, OC 2-4 alkynyl, halogen, nitro, N(R) 2 , NRSO 2 CH 3 , SO 2 NRCH 3 . (CH 2 ) r CO 2 R 3 , (CH 2 ) r SO 3 H, (CH 2 ) r PO 3 H 2 , (CH 2 ) r PO 3 RH, O(CH 2 ) r CO 2 R 3 , O(CH 2 ) r SO 3 H, O(CH 2 ) r PO 3 H 2 , O(CH 2 ) r PO 3 RH, S(CH 2 ) r CO 2 R 3 , S(CH 2 ) r SO 3 H, S(CH 2 ) r PO 3 H 2 , NHR 3 CONHR 3 , NHCO 2 R 3 , S(CH 2 ) r PO 3 RH, (CH 2 ) r CON(R 3 ) 2 , S(CH 2 ) n CON(R 3 ) 2 , O(CH 2 ) n CON(R 3 ) 2 , (CH 2 ) r NR 3 SO 2 R, (CH 2 ) r C(═NR 3 )N(R 3 ) 2 , (CH 2 ) r NR 3 C(═NR 3 )N(R 3 ) 2 , (CH 2 ) r NR 3 (C═NR 3 CN)N(R 3 ) 2 , (CH 2 ) r NR 3 (C═CHNO 2 )N(R 3 ) 2 , (CH 2 ) r NR 3 C(═NR 5 )NR 3 R 5a , (CH 2 ) r tetrazol-5-yl, and O(CH 2 CH 2 O) q R 4 ; R A is selected from H, C R Z is selected from NRZ′, CH Z′ is selected from (CH) Q is selected from N, CH, and CQ′; Q′ is selected from H, CO V is selected from H, C R is independently selected from H and C R R R V m is selected from 0, 1, 2, 3, and 4; n is selected from 1, 2, 3, and 4; and, p is selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12.