Patent ID: 7838020
Filing Date: 2010-11-23
Classification: A61K,A61P,A61Q

Abstract:
1. A composition comprising an N-acylaminoamide elastase inhibitor and at least one metalloproteinase inhibitor selected from the group consisting of adapalene, Batimastat, Marimastat, carotenoids, sunscreens, vitamin C, isoflavones, retinol, retinoic acid, and lycopene, wherein the elastase inhibitor is a compound of the formula (I): where the Y radical represents O or S, the R optionally substituted by 1 to 5 groups, either identical or different, selected from the group consisting of —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH said R and R′ radicals being able to form together with N a carbon ring with 5 to 6 ring members optionally further comprising at least one heteroatom being selected from the group consisting of O, N and S in the ring and/or optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH (iii) a radical selected from the group consisting of —OR; —NH with R and R′ representing, independently from each other, a linear, branched or cyclic, saturated or unsaturated hydrocarbon radical having 1 to 6 carbon atoms, optionally being halogenated,; said R and R′ radicals being able to form together with N a carbon ring with 5 to 6 ring members optionally comprising, additionally, at least one heteroatom selected from the group consisting of O, N and S in the ring and/or optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH the R the R where y is an integer between 0 and 5 inclusive, and y′ is an integer between 1 and 5 inclusive; A is a linear or branched, saturated or unsaturated hydrocarbon divalent radical, with 1 to 18 carbon atoms, optionally being substituted by 1 to 5 groups, either identical or different, selected from the group consisting of —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH with R and R′ representing, independently from each other, a linear, branched or cyclic, saturated or unsaturated hydrocarbon radical, with 1 to 6 carbon atoms, optionally being halogenated; said R and R′ radicals being able to form together with N a carbon ring with 5 to 6 ring members optionally comprising further at least one heteroatom selected from the group consisting of O, N and S in the ring and/or optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH B is a linear or branched, saturated or unsaturated hydrocarbon radical having 1 to 18 carbon atoms, optionally substituted by 1 to 5 groups, either identical or different, selected from the group consisting of —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH with R and R′ representing, independently from each other, a linear, branched or cyclic, saturated or unsaturated hydrocarbon radical having 1 to 6 carbon atoms, optionally being halogenated; said R and R′ radicals being able to form together with N a carbon ring with 5 to 6 ring members optionally comprising further at least one heteroatom selected from the group consisting of O, N and S in the ring and/or optionally substituted by 1 to 5 groups, identical or different, selected from the group consisting of —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH the X radical is a radical selected from the group consisting of —OH; —OR with R