Patent ID: 6787655
Filing Date: 2004-09-07
Classification: C07B,C07C,C40B

Abstract:
The method represented by the generalized reaction depicted in Scheme 1: whereinZ represents an electron withdrawing group selected from the group consisting of formyl, acyl, â€”CN, â€”C(O)OR, â€”C(O)N(R)2, nitro, nitroso, â€”S(O)2R, â€”S(O)2N(R)2, â€”C(NR)â€”R, â€”C(NOR)â€”R, and â€”C(NN(R)2)â€”R; R represents independently for each occurrence hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or â€”(CH2)mâ€”R80; R1, R2, and R3 are independently selected from the group consisting of H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, â€”Si(R)3, and â€”(CH2)mâ€”R80; the transition metal catalyst consists essentially of an asymmetric bidentate ligand and a copper complex selected from the group consisting of copper carboxylates, copper carbonates, copper sulfates, copper sulfonates, copper halides, copper trifluoroborates, copper phosphates and mixtures thereof; Nu represents hydrogen; NuW is a silane or polymethylhydrosiloxane (PMHS); the base is selected from the group consisting of alkoxides, phenoxides, and amides; taken together, any two groups selected from Z, R1, R2, and R3 may form a ring comprising a total of 5-7 atoms in the backbone of said ring; said ring may comprise one or two heteroatoms in its backbone; and said ring may bear instances of R; R80 represents independently for each occurrence amyl, cycloalkyl, cycloalkenyl heterocyclyl, or polycyclyl; m is an integer in the range 0 to 8 inclusive; and the carbon marked with an asterisk in compound 2 is asymmetric.