Patent ID: 6713467
Filing Date: 2004-03-30
Classification: A61K,A61P,C07B,C07C,C07D

Abstract:
A compound having the formula (I), or a pharmaceutically-acceptable salt thereof, in which:ring B is phenyl; W is selected from C2-10alkyl, C2-10alkenyl, substituted C2-10alkyl, substituted C2-10alkenyl, â€”C(&boxH;O)NR9R10, â€”OR9, â€”CO2R9, â€”C(&boxH;O)R9, â€”SR9, â€”S(O)pR9, â€”NR9R10, â€”NR9SO2R10, â€”NR9CO2R10, â€”NR9C(&boxH;O)R10, â€”SO2NR9R10, heterocyclo, heteroaryl, aryl, and cycloalkyl; Z1 is a 5 to 7-membered monocyclic or 8 to 11-membered bicyclic aryl, heteroaryl, heterocyclo, or cycloalkyl; L is â€”(CR18R19)sâ€”Yâ€”(CR18aR19a)tâ€”; Y is selected from â€”C(&boxH;O), â€”C(&boxH;O)NR13â€”, â€”NR13C(&boxH;O)â€”, â€”NR13CR14R15â€”, â€”CR14R15â€”NR13â€”, and â€”CR13R14â€”CR15R16â€”; R1 and R2 are taken together to form a five-to-seven membered fully saturated heterocycle containing N, and optionally substituted with one to two R26; R5 and R6 are independently selected from hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, â€”C(&boxH;O)H, acyl, â€”CO2H, and alkoxycarbonyl, provided that at least one of R5 and R6 is hydrogen; R7 is attached to any available carbon or nitrogen atom of Z1 and is selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroalkyl, substituted heteroalkyl, â€”C(&boxH;O)H, acyl, â€”CO2H, alkoxycarbonyl, sulfonyl, sulfonamido, aryl, heteroaryl, heterocyclo, or cycloalkyl, except when Z is phenyl, W is OCH3, s is 0 and Y is â€”CH2â€”CH2â€”, then R7 is not phenyloxy; R8 is hydrogen, alkyl, substituted alkyl, heteroaryl, aryl, heterocyclo, cycloalkyl, or alkyl substituted with â€”OC(&boxH;O)R24 or â€”OC(&boxH;O)Oâ€”R24, wherein R24 is alkyl, substituted alkyl, or cycloalkyl, provided that R8 is not phenyl when W is methoxy; R9, R9a, and R10 are (i) independently selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, substituted heteroalkyl, aryl, heteroaryl, heterocyclo, cycloalkyl, and alkyl having one, two, or three substituents selected from the group consisting of halo, alkenyl, alkynyl, nitro, cyano, hydroxy, alkoxy, alkylthio, â€”CO2H, â€”C(&boxH;O)H, â€”CO2-alkyl, â€”C(&boxH;O)alkyl, â€”S(O)2(alkyl), keto (&boxH;O), aryl, heteroaryl, heterocyclo, and cycloalkyl, including phenyl, benzyl, phenylethyl, phenyloxy, and phenylthio; or alternatively (ii) R9 and R10 may be taken together to form a five-to-seven membered heteroaryl or heterocyclo, except when W is â€”S(O)pR9, then R9 is not hydrogen; R13, R14, R15, R16, R18, R18a, R19, and R19a are selected from hydrogen, lower alkyl, hydroxy, or lower alkyl substituted with hydroxy or halogen; R26 and R27 (i) are at each occurrence independently selected from hydrogen, OR30, NR31R32, NR31 SO2R32a, alkyl, alkenyl, substituted alkyl, substituted alkenyl, halogen, haloalkyl, haloalkoxy, cyano, nitro, alkylthio, â€”C(&boxH;O)H, acyl, â€”CO2H, alkoxycarbonyl, sulfonamido, sulfonyl, and phenyl, or (ii) two of R26 and/or two of R27 may be taken together to form a fused benzo ring, a fused heteroaryl, a fused cycloalkyl, or a fused heterocyclo other than a five or six membered heterocyclo having as its heteroatoms two oxygen atoms; R30 at each occurrence is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, and phenyl; R31 and R32 at each occurrence are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, and cycloalkyl; R32a is alkyl, substituted alkyl, alkenyl, substituted alkenyl, or cycloalkyl; m is 0, 1 or 2 when ring B is phenyl and 0 or 1 when ring B is pyridyl; p and q are independently 1 or 2; and s and t are independently 0, 1 or 2.