Patent ID: 7960570
Filing Date: 2011-06-14
Classification: A61K,A61P,C07D

Abstract:
1. A method of making (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid, comprising the steps of: i) reacting L-proline methyl ester hydrochloride with methyl oxalyl chloride to form methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate; ii) reacting the methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate obtained in step (i) with 1,1-dimethylpropylmagnesium chloride to form methyl (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylate; iii) reacting the methyl(2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate obtained in step (ii) with LiOH to form (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid.