Patent ID: 9096850
Filing Date: 2015-08-04
Classification: C12N

Abstract:
1. A double-stranded miRNA mimetic molecule represented by Formula III: wherein (a) the molecule comprises a contiguous passenger strand and a guide strand where each line and its adjacent “N” represent a contiguous stretch of nucleotides, each of “X1,” “X2” and “X3” represent the number of nucleotides in each stretch, “G/N” represents a discontinuity in the guide strand, “Y1” represents a number of nucleotide positions in the discontinuity, and each group of dashed lines “ - - - ” and its adjacent “(W)” represents a terminal overhang that is optionally present, and each of “Z1” and “Z2” represents the number of overhanging nucleotides; (b) X1 is an integer from 16 to 26, X2 is an integer from 2 to 20, X3 is an integer from 6 to 24, Y1 is an integer from 0 to 6, provided that the sum of X2, X3 and Y1 is an integer from 16 to 26; Zi and Z2 are independently integers from 0 to 4; (c) N (d) N (e) N