Patent ID: 8034787
Filing Date: 2011-10-11
Classification: A61K,A61P

Abstract:
1. A method for treating colorectal cancer, breast cancer and cervical cancer in a patient in need thereof, the method comprising administering a therapeutically effective amount of a compound comprising: (1) a therapeutic agent capable of entering a target cell, wherein said therapeutic agent is an alkylating agent, antiproliferative agent, tubulin binding agent, vinca alkaloid, enediyne, podophyllotoxin, podophyllotoxin derivative, a member of the pteridine family of drugs, taxane, a dolastatin, topoiosomerase inhibitor, or a platinum complex chemotherapeutic agent, (2) an oligopeptide of the formula (AA) (3) a negatively charged stabilizing group, and (4) optionally, a linker group not cleavable by TOP, wherein the oligopeptide is directly linked to the stabilizing group at the amino terminus of the oligopeptide and the oligopeptide is directly linked to the therapeutic agent or indirectly linked through the linker group to the therapeutic agent at a second attachment site of the oligopeptide, wherein the stabilizing group reduces acute toxicity of the compound when administered in vivo, and wherein the compound is cleavable by TOP.