Patent ID: 7378506
Filing Date: 2008-05-27
Classification: C07K,C12N

Abstract:
1. An isolated polypeptide, comprising a) a first elastin module comprising at least four amino acids, wherein the elastin module comprises amino acid sequence GVP (amino acids 1 to 3 of SEQ ID NO: 277), flanked on the N-terminal side by a first extensin module comprising amino acid sequence SOOOOTO (SEQ ID NO: 280), wherein S is serine and O is hydroxyproline, the extensin module further comprising a first crosslinkage motif chosen from amino acid sequences VYK (SEQ ID NO: 256) and YYYK (SEQ ID NO: 245) and b) a second elastin module comprising at least four amino acids, wherein the elastin module comprises amino acid sequence GVP (amino acids 1 to 3 of SEQ ID NO: 277), flanked on the C-terminal side by a second extensin module comprising amino acid sequence SOOOOTO (SEQ ID NO: 280), wherein S is serine and O is hydroxyproline, the extensin module further comprising a second crosslinkage motif chosen from amino acid sequences VYK (SEQ ID NO: 256) and YYYK (SEQ ID NO: 245).