Patent ID: 6957150
Filing Date: 2005-10-18
Classification: C12N

Abstract:
1. A method for identifying an agent that interacts with an active site of acyl carrier protein synthase (ACPS), comprising the steps of: (a) obtaining a crystallized ACPS, wherein the crystallized ACPS is characterized as being in plate form with space group P2 (b) obtaining the structural coordinates of the crystallized ACPS of step (a), wherein the structural coordinates are set forth in FIG. (c) generating a three dimensional model of ACPS using the structural coordinates of the amino acids of ACPS obtained in step (b), and ± a root mean square deviation from the backbone atoms of not more than 1.5 Å; (d) determining an active site of ACPS from said three dimensional model; and (e) performing computer fitting analysis to identify an agent which interacts with said active site.