Patent ID: 7989612
Filing Date: 2011-08-02
Classification: A61K,C07F,C12N,Y02A

Abstract:
1. A chemically modified short interfering nucleic acid molecule, wherein: a) the nucleic acid molecule comprises a sense strand and a separate antisense strand, where the antisense strand is complementary to a viral target RNA sequence; b) each strand of the nucleic acid molecule is independently 18 to 24 nucleotides in length; c) all pyrimidine nucleotides present in the sense strand are 2′-deoxy-2′-fluoro nucleotides and all purine nucleotides present in the sense strand are 2′-deoxy nucleotides; and d) all pyrimidine nucleotides present in the antisense strand are 2′-deoxy-2′-fluoro pyrimidine nucleotides and all purine nucleotides present in the antisense strand are 2′-O-methyl nucleotides.