Patent ID: 6756385
Filing Date: 2004-06-29
Classification: A61P,C07D

Abstract:
A compound of the formula wherein R1 is (C3-C8)cycloallcyl, (C4-C8)cycloalkenyl, (C5-C11)bycycloalkyl, (C7-C11)bicycloalkenyl, or (C6-C14)aryl; and wherein R1 is optionally substituted with from one to six substituents R5 independently selected from F, Cl, Br, I, nitro, cyano, â€”CF3, â€”NR7R8, â€”NR7C(&boxH;C)R8, â€”NR7C(&boxH;O)OR8, â€”NR7C(&boxH;O)NR8R9, â€”NR7S(&boxH;O)2R8, â€”NR7S(&boxH;O)2NR8R9, â€”OR7, â€”OC(&boxH;O)R7, â€”OC(&boxH;O)OR7, â€”C(&boxH;O)OR7, â€”C(&boxH;O)NR7R8, â€”OC(&boxH;O)NR7R8, â€”OC(&boxH;O)SR7, â€”SR7, â€”S(&boxH;O)R7, â€”S(&boxH;O)2R7, â€”S(&boxH;O)2NR7R8, â€”Oâ€”S(&boxH;O)2R7, â€”N3, and R7;R2 is H, F, â€”CH3, â€”CN, or â€”C(&boxH;O)OR7; R3 is â€”C(&boxH;O)NR9â€”, â€”C(&boxH;O)Oâ€”, â€”C(&boxH;O)(CR10R11)nâ€”, or â€”(CR10R11)nâ€”; R4 is quinolyl; and wherein R4 is optionally substituted with from one to three substitutents R6 independently selected from F, Cl, Br, I, nitro, cyano, â€”CF3, â€”NR7R8, â€”NR7C(&boxH;O)R8, â€”NR7C(&boxH;O)OR8, â€”NR7C(&boxH;O)NR8R9, â€”NR7S(&boxH;O)2R 8, â€”NR7S(&boxH;O)2NR8R9, â€”OR7, â€”OC(&boxH;O)R7, â€”OC(&boxH;O)OR7, â€”C(&boxH;O)OR7, â€”C(&boxH;O)R7, â€”C(&boxH;O)NR7R8, â€”OC(&boxH;O)NR 7R8, â€”OC(&boxH;O)SR7, â€”SR7, â€”S(&boxH;O)R7, â€”S(&boxH;O)2R7, â€”S(&boxH;O)2NR7R8, or R7; each R7, R8, and R9 is independently selected from H, straight chain or branched (C1-C8)alkyl, straight chain or branched (C2-C8)alkenyl, straight chain or branched (C2-C8alkynyl), (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, (C5-C11)bicycloalkyl, (C7-C11)bicycloalkenyl, and (C6-C14)aryl, wherein R7, R8, and R9 are each independently optionally substituted with from one to six substituents independently selected from F, Cl, Br, I, NO2, â€”CN, â€”CF3, â€”NR10R11, â€”NR10C(&boxH;O)R11, â€”NR10C(&boxH;O)OR11, â€”NR10C(&boxH;O)NR11R12, â€”NR10S(&boxH;O)2NR11R12, â€”OR10, â€”OC(&boxH;O)R10, â€”OC(&boxH;O)OR10, â€”OC(&boxH;O)NR10R11, â€”OC(&boxH;O)SR10, â€”SR10, â€”S(&boxH;O)R10, â€”S(&boxH;O)2R10, â€”S(&boxH;O)2NR10R11, â€”C(&boxH;O)R10, â€”C(&boxH;O)OR10, â€”C(&boxH;O)NR10R11, and R10; each R10, R11, and R12 is independently selected from H, straight chain or branched (C1-C8)alkyl, straight chain or branched (C2-C8)alkenyl, straight chain or branched (C2-C8alkynyl), (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, (C5-C11)bicycloalkyl, (C7-C11)bicycloalkenyl, and (C6-C14)aryl, wherein R10, R11, and R12 are each independently optionally substituted with from one to six substituents independently selected from F, Cl, Br, I, â€”NO2, â€”CN, â€”CF3, â€”NR13R14, â€”NR13C(&boxH;O)R14, â€”NR3C(&boxH;O)OR14, â€”NR13C(&boxH;O)NR14R15, â€”NR13S(&boxH;O)2R14, â€”NR13S(&boxH;O)2NR14R15, â€”OR13, â€”OC(&boxH;O)R13, â€”OC(&boxH;O)OR13, â€”OC(&boxH;O)NR13R14, â€”OC(&boxH;O)SR13, â€”SR 13, â€”S(&boxH;O)R13, â€”S(&boxH;O)2R13, â€”S(&boxH;O)2NR13R14, â€”C(&boxH;O)R13, â€”C(&boxH;O)OR13, â€”C(&boxH;O)NR13R14, and R13; each R13, R14, and R15 is independently selected from H, straight chain or branched (C1-C8)alkyl, straight chain or branched (C2-C8)alkenyl, straight chain or branched (C2-C8alkynyl), (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, (C5-C11)bicycloalkyl, (C7-C11)bicycloalkenyl, and (C6-C14)aryl, wherein R13, R14, and R15 are each independently optionally substituted with from one to six substituents independently selected from F, Cl, Br, I, â€”NO2, â€”CN, â€”CF3, â€”NR16R17, â€”NR16C(&boxH;O)R17, â€”NR16(C&boxH;O)OR17, â€”NR16C(&boxH;O)NR17R18, â€”NR16S(&boxH;O) 2R17, â€”NR16S(&boxH;O)2NR17R18, â€”OR16, â€”OC(&boxH;O)R16, â€”OC(&boxH;O)OR16, â€”OC(&boxH;O)NR16R17, â€”OC(&boxH;O)SR16, â€”SR16, â€”S(&boxH;O)R16, â€”S(&boxH;O)2R16, â€”S(&boxH;O)2NR16R17, â€”C(&boxH;O)R16, â€”C(&boxH;O)OR16, â€”C(&boxH;O)NR16R17, and R16; each R16, R17, and R18 is independently selected from H, straight chain or branched (C1-C8)alkyl, straight chain or branched (C2-C8)alkenyl, straight chain or branched (C2-C8alkynyl), (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, (C5-C11)bicycloalkyl, (C7-C11)bicycloalkenyl, and (C6-C13)aryl, n is 0, 1, 2, or 3; wherein R10 and R11 in â€”C(&boxH;O)(Cr10R11)nâ€” and â€”(CR10R11)nâ€” are for each iteration of n defined independently as recited above; or a pharmaceutically acceptable salt thereof.