Patent ID: 6696423
Filing Date: 2004-02-24
Classification: A61K,C07K,C12N

Abstract:
A method for treating cancer by in vivo interferon-&bgr; gene therapy comprising the steps of:administering to a subject, at or near the site of a tumor, a viral vector comprising a gene that encodes interferon-&bgr; protein, and allowing said interferon-&bgr; protein to be expressed from said gene in said subject in an amount sufficient to cause cancer regression or inhibition of cancer growth, wherein said viral vector is selected from the group consisting of an adenoviral vector, a lentiviral vector, a baculoviral vector, an Epstein Barr viral vector, a papovaviral vector, a vaccinia viral vector and a herpes simplex viral vector, and wherein if the viral vector is-an adenoviral vector, then the subject is not exposed to a nucleic acid encoding a selectable marker gene.