Patent ID: 6492146
Filing Date: 2002-12-10
Classification: C12P

Abstract:
A process for the preparation of phosphatidyl-serine of formula (I) In which R1 and R2 are independently saturated, monounsaturated or polyunsaturated acyl C10-C30, X=OH or OM, wherein M is an inner salt, alkali or alkaline-earth metal, ammonium or alkylammonium comprising the reaction of a phosphatide of general formula (II) In which R1, R2 and X have the meanings defined above and R3â€”CH2â€”CH2â€”NH2 or CH2â€”CH2â€”N+(CH3)3, with racemic or enantiomerically pure serine, or (L)-serine, in the presence of the enzyme phospholipase D (PLD) and a surfactant in a quantity not greater than 0.4 grams per gram of substrate, wherein the reaction medium is an aqueous dispersion free of organic solvents.