Patent ID: 8334693
Filing Date: 2012-12-18
Classification: G01N,G01R

Abstract:
1. A device for the magnetic resonance detection of one or more analytes in a liquid sample, the device comprising a support defining a well holding a liquid sample comprising magnetic particles and the one or more analytes and having an RF coil disposed about the well, the RF coil configured to detect an echo response produced by exposing the liquid sample to a bias magnetic field created using one or more magnets and an RF excitation, wherein the magnetic particles have binding moieties on their surfaces, the binding moieties operative to alter an aggregation of the magnetic particles in the presence of the one or more analytes, and wherein at least one of the binding moieties is operative to bind to at least one of the following: (i) the one or more analytes; (ii) another of the binding moieties; and (iii) an aggregation-inducing molecule in the liquid sample, thereby producing an aggregate of multiply-linked magnetic particles as a function of the presence or concentration of the one or more analytes in the liquid sample.