Patent ID: 7919301
Filing Date: 2011-04-05
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An infectious, self-replicating human parainfluenza virus type 2 (HPIV2) particle comprising a PIV major nucleocapsid (N) protein, a PIV nucleocapsid phosphoprotein (P), a PIV large polymerase (L) protein and a partial or complete polyhexameric HPIV2 genome or antigenome, wherein the partial or complete HPIV2 genome or antigenome comprises a polynucleotide providing the 3′leader sequence of a HPIV2 and polynucleotides encoding HPIV2 N, P and L proteins and the polynucleotide encoding the L protein includes a mutation at the amino acid aligning with position 20 of SEQ ID NO: 1 to an amino acid other than phenylalanine.