Patent ID: 6103463
Filing Date: 2000-08-15
Classification: B01J,B82Y,C12N,C12Q,C40B,Y10S

Abstract:
A method of sorting a mixture of nucleic acid strands comprising the steps of:a) providing a solution containing a mixture of nucleic acid strands in single-stranded form andb) contacting said solution to a first binary oligonucleotide array of predetermined areas on a surface of a solid support, each area having therein, covalently linked to said surface, copies of a binary oligonucleotide, said binary oligonucleotide consisting of a constant nucleotide sequence adjacent to a variable nucleotide sequence, wherein the constant nucleotide sequence is the same for all oligonucleotides in the array, wherein said step of contacting is carried out under conditions promoting perfect hybridization of said strands to said binary oligonucleotides.