Patent ID: 6627425
Filing Date: 2003-09-30
Classification: A01K,A61K,A61P,C12N

Abstract:
An isolated nucleic acid molecule selected from the group consisting of:a) a nucleic acid molecule having a nucleotide sequence which is at least 91% identical over its entire length to the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO:2, the nucleotide sequence of the clone deposited with American Type Culture Collection on Jul. 28, 2000 as accession number PTA-2282; b) a nucleic acid molecule comprising at least 165 nucleotide residues and having a nucleotide sequence identical to at least 165 consecutive nucleotide residues of SEQ ID NO: 1 or SEQ ID NO: 2, the nucleotide sequence of the clone deposited with American Type Culture Collection on Jul. 28, 2000 as accession number PTA-2282; c) a nucleic acid molecule which encodes a fragment of a polypeptide having the amino acid sequence of SEQ ID NO: 3 or the amino acid sequence encoded by the clone deposited with American Type Culture Collection on Jul. 28, 2000 as accession number PTA-2282, wherein the fragment comprises at least 60 consecutive amino acids of SEQ ID NO: 3 or the amino acid sequence encoded by the clone deposited with American Type Culture Collection on Jul. 28, 2000 as accession number PTA-2282; and d) a nucleic acid molecule which hybridizes with a nucleic acid molecule having a sequence comprising SEQ ID NO: 1 or SEQ ID NO: 2, or the nucleotide sequence of the clone deposited with American Type Culture Collection on Jul. 28, 2000 as accession number PTA-2282, or with a full complement thereof, under conditions of hybridization of 6Ã—SSC at 45Â° C. and washing in 0.2Ã—SSC, 0.1% SDS at 65Â° C.; wherein the polypeptide or the fragment of the polypeptide has human pancreatic islet cell-specific glucox-6-phosphatase (h-ig6p) activity.