Patent ID: 6270758
Filing Date: 2001-08-07
Classification: A61K,A61P,Y10S

Abstract:
A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of:(a) providing an antigen-adjuvant composition comprising the antigen and a substantially nontoxic cytokine adjuvant molecule having biological activity in mucosal tissues and having less immunogenicity than cholera toxin, wherein the antigen-adjuvant composition is soluble in water, and wherein the cytokine adjuvant molecule is selected from the group consisting of an IL, GM-CSF, and combinations thereof; and(b) administering said antigen-adjuvant composition intramucosally to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited, the immune response comprising a systemic immune response.