Patent ID: 8961948
Filing Date: 2015-02-24
Classification: C08G

Abstract:
1. A method for creating a biotinylated polymer comprising: (a) providing a biocompatible polymer comprising tyrosine-derived monomeric repeating units having the structure: wherein each X is independently H, I or Br, Y1 and Y2 for each diphenol unit are independently between 0 and 4, inclusive; each R wherein j and m are independently an integer from 1 to 8, inclusive, and wherein the subgroup R 1 is an OH group; (b) activating the carboxylic acid group on said biocompatible polymer, thereby priming the carboxylic acid residues for nucleophilic attack; and (c) reacting the activated carboxylic acid group with a nucleophile, wherein the nucleophile comprises biotin.