Patent ID: 9114154
Filing Date: 2015-08-25
Classification: A61K,A61P,A61Q,C08L,C11D

Abstract:
1. A composition comprising a carrier and a superhydrophilic amphiphilic copolymer comprising a starch-based or cellulose-based polysaccharide modified with a hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammonium chloride, wherein the superhydrophilic amphiphilic copolymer comprising the starch-based or cellulose-based polysaccharide modified with the hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammonium chloride has a weight average molecular weight that is less than about 200,000 and a solution viscosity of less than about 9 centipoise, wherein the superhydrophilic amphiphilic copolymer modified with the hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammonium chloride is prepared by forming an aqueous solution of the starch-based or cellulose-based polysaccharide in water by dissolving from about 25% to about 75% of the starch-based or cellulose-based polysaccharide in water, based on total weight of the aqueous solution, to produce the aqueous solution comprising the starch-based or cellulose-based polysaccharide, adding the hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammonium chloride to the aqueous solution, and reacting the hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammonium chloride with the starch-based or cellulose-based polysaccharide dissolved in the aqueous solution at a pH of 11.5 or greater to form an aqueous solution of the superhydrophilic amphiphilic copolymer comprising the starch-based or cellulose-based polysaccharide modified with the hydrophobic reagent comprising at least one 3-chloro-2-hydroxypropylalkyldimethylammoniumchloride.