Patent ID: 8489339
Filing Date: 2013-07-16
Classification: A61P,C07K

Abstract:
1. A method of drug selection comprising, a) obtaining a crystal belonging to the space group P6 b) determining the three-dimensional structure of the complex by the X-ray diffraction method to obtain the atomic coordinates in Table 1; c) screening the atomic coordinates of Table 1 against a database of chemical entities to identify a chemical entity putatively able to associate with an interactive surface between granulocyte macrophage-colony stimulating factor (GM-CSF), GM-CSF receptor subunit alpha (GM-CSFRα) and GM-CSF receptor subunit beta-c (βc), wherein the interactive surface is selected from the group consisting of: d) selecting a chemical entity which computationally associates with the interactive surface for testing in a GM-CSF activity assay, e) incorporating said selected chemical entity into a biological cytokine activity assay; and f) determining whether said chemical entity inhibits the biological activity of human GM-CSF-mediated signaling.