Patent ID: 6040145
Filing Date: 2000-03-21
Classification: A61K,A61P,G01N,Y02A

Abstract:
A method for stimulating proliferation of T-cells of a human patient; said method comprising contacting said T-cells, in vitro, with an organic compound having the structure: ##STR2## wherein B is boron, each D1 and D2 independently, is a hydroxyl group or a group which is capable of being hydrolyzed to a hydroxyl group in aqueous solution at physiological pH; and X comprises an amino acid or a peptide which mimics the site of a substrate recognized by a post-prolyl cleaving enzyme; at an in vitro concentration below 10.sup.-8 M, wherein said compound inhibits the post-prolyl cleaving dipeptidase activity present in the cytoplasm of Jurkat cells and said patient suffers from a disease state caused by HIV infection.