Patent ID: 8497350
Filing Date: 2013-07-30
Classification: A61K,A61P,C07K,C12N,C12Q

Abstract:
1. A pharmaceutical composition for administration to a human patient comprising a Complement Factor H (CFH) polypeptide, wherein the Complement Factor H polypeptide (a) has at least 90% sequence identity to SEQ ID NO:2, comprises isoleucine at position 62, numbered relative to SEQ ID NO:2, comprises tyrosine at residue 402, numbered relative to SEQ ID NO:2, and binds complement component 3b (C3b), or (b) comprises a fragment of (a) that binds C3b and comprises isoleucine at residue 62 and tyrosine at residue 402, both numbered relative to SEQ ID NO:2, and a pharmaceutically acceptable excipient, wherein said composition is free of pathogens and suitable for administration to a human patient.