Patent ID: 6362165
Filing Date: 2002-03-26
Classification: A61K,C07C,C07K

Abstract:
An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula I comprises an amino group pharmaceutically acceptable ammonium salts thereof,wherein n is 1, 2 or 3, e is 1, 2 or 3, Hal represents a halogen atom, p is 0, 1 or 2, r is 0, 1 or 2, X and Xâ€² each independently represents a single bond, a saturated straight or branched hydrocarbon group of 1 to 4 carbon atoms or a straight or branched hydrocarbon group of 2 to 4 carbon atoms comprising a carbon to carbon double bond, Ra represents H or CH3â€”, Raa represents H or CH3â€”, W represents a group of formula wherein k is 0 or 1, A and Aâ€² each independently represents a group of formula wherein Ra is as defined above, Rb represents H or CH3â€”, Rc represents H or OH, R is selected from the group consisting of H, CH3â€”, (CH3)2CHâ€”, (CH3)2CHCH2â€”, CH3CH2CH(CH3)â€”, C6H5CH2â€”, CH3SCH2CH2â€”, HO2CCH2â€”, H2NC(O)CH2â€”, HO2CCH2CH2â€”, H3NC(O)CH2CH2â€”, H2NCH2CH2CH2CH2â€”, HOCH2â€”, CH3CH(OH)â€”, HSCH2â€”, wherein Hal is as defined above and f is 0, 1 or 2, and g is 0, 1 or 2 and provided that when W represents a group of formula n is 3 when Ra is H, Rb is H and R is H, a group of formula HO2CCH2CH2â€”, a group of formula or a group of formula