Patent ID: 6780867
Filing Date: 2004-08-24
Classification: A61P,C07D

Abstract:
A compound of the formula I in whichR1 and R2 are each, independently of one another, H, A, OH, OA, NO2 or Hal, R1 and R2 together are alternatively alkylene having 3-5 carbon atoms, â€”Oâ€”CH2â€”CH2â€”, â€”CH2â€”Oâ€”CH2â€”, â€”Oâ€”CH2â€”Oâ€” or â€”Oâ€”CH2â€”CH2â€”Oâ€”, X is mono-R5-substituted R3 or R4, R3 is linear or branched alkylene having 1-10 carbon atoms, in which one or two CH2 groups are optionally replaced by â€”CH&boxH;CHâ€” groups, O, NH or NA, R4 is cycloalkyl or cycloalkylalkylene having 5-12 carbon atoms, R5 is O(CH2)nCOOH, O(CH2)nCOOA, O(CH2)nCONH2, O(CH2)nCONHA, O(CH2)nCONA2, O(CH2)nCN, S(O)m(CH2)nCOOH, S(O)m(CH2)nCOOA, S(O)m(CH2)nCONH2, S(O)m(CH2)nCONHA, S(O)m(CH2)nCONA2 or S(O)m(CH2)nCN m is 0, 1 or 2, n is 1 or 2, A is alkyl having 1 to 6 carbon atoms, and Hal is F, Cl, Br or I, or a physiologically acceptable salt thereof.