Patent ID: 9012217
Filing Date: 2015-04-21
Classification: C07D,C12N

Abstract:
1. A method for producing mammalian mesodermal or cardiomyocyte cells from mammalian stem cells, comprising contacting within the same suitable medium Activin A and the stem cells with a compound of structure II in the form of a free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: wherein: A is NH; and B is an aromatic ring, wherein the aromatic ring is optionally substituted phenyl, optionally substituted benzyl, or has the structure of or is an unsaturated 5 or 6 member ring, optionally substituted, containing a heteroatom wherein the heteroatom is N or O, or A is absent and B is optionally substituted phenyl, D is N or CH, E is N, CH, C—R, or C—OH; F is N or CH, G is aryl, heteroaryl or cyclohexyl optionally substituted by 1 to 5 R I is N or C; R is hydrogen or (C R R