Patent ID: 8680020
Filing Date: 2014-03-25
Classification: C40B,G01N,H01J

Abstract:
1. An array of carbohydrates immobilized on an aluminum-coated non-transparent solid substrate or a polyfluorinated aluminum-coated non-transparent solid substrate, the array comprising: a plurality of carbohydrates immobilized at discrete locations on a surface of the aluminum-coated non-transparent solid substrate, such that (a) the immobilized carbohydrates, which are polyfluorinated with a —CnF2n+1 (n>=4) tail, can be characterized by mass spectroscopy (MS) without addition of a miscible organic matrix, and (b) analysis of binding reactions between the immobilized carbohydrates and molecules suspected of specifically binding the carbohydrates can be performed, comprising detecting a fluorescent signal coupled to the molecules, and wherein the intensity of a fluorescent signal generated on the surface of the aluminum-coated solid substrate is detectable with higher sensitivity than on the surface of a transparent solid substrate wherein the substrate is conductive or semiconductive of an electrical field, wherein aluminum is coated on a first transparent solid substrate at a thickness greater than 100 nm to render the first transparent solid substrate into an aluminum coated non-transparent solid substrate, and wherein the surface of the aluminum-coated solid substrate is anodized to form a porous aluminum oxide layer of thickness less than 5 nm.