Patent ID: 6437025
Filing Date: 2002-08-20
Classification: A61K,C08G,Y10S

Abstract:
A method for preparing an activated water soluble polymer, said polymer comprising a polymer backbone having at least one terminus bonded to a branching moiety through a hydrolytically stable linkage, the branching moiety being covalently bonded to at least two reactive groups, each reactive group comprising a reactive moiety, comprising:providing a first polymer comprising the polymer backbone linked to a reactive end group; providing a branched reactive compound having at least three free reactive groups linked to a branching moiety, one of said at least three free groups being capable of reacting with the reactive end group of the first polymer; and reacting the reactive end group of the first polymer with one of the at least three free groups of the branched reactive compound to form a hydrolytically stable linkage between the polymer backbone of the first polymer and the branched reactive compound, thereby forming a second polymer having at least two free reactive groups at a terminus thereof, each reactive group comprising a reactive moiety.