Patent ID: 7632497
Filing Date: 2009-12-15
Classification: A61P,C07K,G01N

Abstract:
1. A modified antibody that binds an antigen, said modified antibody comprising a variant human IgG1 Fc region, wherein said variant human IgG1 Fc region comprises at least one amino acid modification relative to the human IgG1 Fc region of a parent antibody that binds said antigen, said amino acid modification(s) comprising amino acid modification(s) that alter the affinity or avidity of the variant Fc region for binding to an FcγR, such that said modified antibody exhibits, in an in vitro assay, detectable effector function activity mediated by said FcγR binding in cells positive for said antigen, and said parent antibody does not exhibit said detectable effector function activity in said cells using said in vitro assay, said amino acid modification(s) that alter the affinity or avidity of the variant Fc region for binding to an FcγR consisting of the modification of 1, 2, 3, 4 or 5 amino acid residues of the IgG1 Fc region of said parent antibody.