Patent ID: 8138185
Filing Date: 2012-03-20
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 3-{2-[3-Cyclopentylmethyl-3-(4-fluoro-3-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; 3-{2-[3-Cyclopentylmethyl-3-(2,4-difluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; 3-{2-[3-Cyclopentylmethyl-3-(2,3-difluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; 3-{2-[3-Cyclopentylmethyl-3-(2,3-difluoro-4-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-2,5-difluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-tert-Butyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-methylsulfanyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-2-methyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-2-fluoro-5-methyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-fluoro-4-methanesulfonyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(3,4-dichloro-2-fluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(3-Acetylamino-2,4-difluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; (2-{3-Cyclopentylmethyl-3-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-ureido}-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(3-fluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(2-Fluoro-4-bromo-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-fluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; [2-(3-Cyclopentylmethyl-3-p-tolyl-ureido)-thiazol-5-ylsulfanyl]-2,2-dimethyl-propionic acid; {2-[3-(4-Chloro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-trifluoromethyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-fluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-fluoro-4-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(3-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; [2-(3-Cyclopentylmethyl-3-tolyl-ureido)-thiazol-5-ylsulfanyl]-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2,4-dichloro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(2-Chloro-4-fluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Chloro-2-fluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(2-Chloro-4-methyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(2-fluoro-4-methyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-fluoro-2-trifluoromethyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-isopropyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-methoxy-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; (2-{3-Cyclopentylmethyl-3-[2-fluoro-4-(2-methoxy-ethoxy)-phenyl]-ureido}-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-trifluoromethoxy-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-fluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-chloro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Chloro-2-trifluoromethyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-methyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(3-oxazol-2-yl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-phenylsulfanyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-2,6-difluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-methyl-2-trifluoromethyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; (2-{3-Cyclopentylmethyl-3-[4-(2-methoxy-ethoxy)-phenyl]-ureido}-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid; (2-{3-Cyclopentylmethyl-3-[4-(morpholine-4-sulfonyl)-phenyl]-ureido}-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(4-ethoxy-2-fluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-Cyclopentylmethyl-3-(3-methanesulfonyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(3-Butylsulfamoyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(4-Bromo-3-chloro-2-fluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; {2-[3-(2-Chloro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; and {2-[3-(3-Chloro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid; or a pharmaceutically acceptable salt thereof.