Patent ID: 9108924
Filing Date: 2015-08-18
Classification: A61P,C07D

Abstract:
1. A process for preparing bendamustine or bendamustine hydrochloride of formula (VI) the process comprising: a) reacting a compound of formula (II), wherein R is C with 2-haloethanol in the presence of calcium carbonate and a solvent to give a compound of formula (III), wherein the solvent comprises acetonitrile; propionitrile; methanol; ethanol; isopropanol; 1,2-dichloroethane; dichloromethane; chloroform dimethylsulfoxide; dimethylformamide; ethyl acetate; isopropyl acetate; dioxane; tetrahydrofuran; or a mixture thereof; b) reacting the compound of formula (III) with a chlorinating agent in the presence of a solvent to provide a compound of formula (IV); c) hydrolyzing the compound of formula (IV) with a lithium source in the presence of a solvent to give a compound of formula (V); and d) converting the compound of formula (V) to bendamustine or bendamustine hydrochloride of Formula VI.