Patent ID: 7619101
Filing Date: 2009-11-17
Classification: A61P,C07D

Abstract:
1. A process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula comprising the step of converting a 4-fluoromethyl-5H-furan-2-one of the formula by way of a catalytic asymmetric hydrogenation in the presence of a chiral catalyst, wherein the chiral catalyst is a ruthenium or a rhodium complex catalyst containing a chiral diphosphine ligand selected from the group consisting of formula IV, V, VI, VII and VIII: wherein R R R R R R R R phenyl substituted by 1 to 5 substituents independently selected from the group consisting of lower alkyl, lower alkoxy, lower dialkylamino, morpholino, phenyl and lower trialkylsilyl, unsubstituted naphthyl, and napthyl substituted by 1 to 7 substituents independently selected from the group consisting of lower alkyl, lower alkoxy, lower dialkylamino, morpholino, phenyl and lower trialkylsilyl; and R