Patent ID: 8431609
Filing Date: 2013-04-30
Classification: C07D

Abstract:
1. A process for preparation of compounds of Formula IV: wherein, a, b, c, e, a′, b′, c′, d′, and e′ are identical or different and are independently hydrogen, a halogen, a (C R d is hydrogen, a halogen, a (C X is independently an aliphatic, or heterocyclic amine, said method comprising the steps of: a. cyclizing in a reaction vessel, and in an inert atmosphere a compound of Formula I by treatment with a cyclizing agent, to afford a first mass; wherein, R R b. separating excess cyclizing agent ; c. amidating of the first mass with an amine in an inert atmosphere, and in the presence of a catalyst and optionally with the help of a nucleating agent to afford an amidated mass; d. separating the excess of amine from the amidated mass to afford a second mass; e. isolating compound of Formula IV from the second mass.