Patent ID: 6060464
Filing Date: 2000-05-09
Classification: A61K,A61P,C07F,Y02P

Abstract:
A method of treating peripheral artery disease by decreasing plasma lipoprotein(a) levels which comprises administering to a patient in need thereof an effective amount of a compound of formula (Ia) ##STR37## wherein X.sup.1 is H, C.sub.(1-3) alkyl, hydroxy or C.sub.(1-4) alkoxy;X.sup.2 is C.sub.(1-3) alkyl or C.sub.(1-4) alkoxy;X.sup.3 is H or C.sub.(1-4) alkyl;R.sup.1, R.sup.2, which may be identical or different, are H or C.sub.(1-3) alkyl;B is CH.sub.2 CH.sub.2, CH.dbd.CH, or CH.sub.2 ;n is zero or 1;Z is H or a C.sub.(1-8) alkyl group;m is 0 or 1;X.sup.4 is H, or C.sub.(1-8) alkyl, C.sub.(1-8) ALKOXY or halo;and the pyridyl ring is attached by the ring carbon .alpha.- or .beta.- to the nitrogen (2- or 3-pyridyl); ora pharmaceutically acceptable salt, thereof.