Patent ID: 8492110
Filing Date: 2013-07-23
Classification: A61K,A61P,A61Q,C12Q,G01N,Y02A

Abstract:
1. A method of preventing cell aging by extending the G0 phase in a cell in a subject in need thereof, the method comprising administering a low dose of a target-of-rapamycin (TOR) inhibitor to a subject, wherein: (a) said TOR inhibitor is rapamycin or an analog thereof selected from the group consisting of Deforolimus, AP-23675, AP-23841, Zotarolimus, CCI779/Temsirolimus, RAD-001/Everolimus, 7-epi-rapamycin, 7-thiomethyl-rapamycin, 7-epi-trimethoxy-rapamycin, 2-desmethyl-rapamycin, and 42-O-(2-hydroxy)ethyl-rapamycin, or a pharmaceutically acceptable salt thereof; and (b) said low dose of TOR inhibitor does not inhibit protein translation and cell growth at G1 phase of cell cycle.