Patent ID: 6541468
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A method for treating Alzheimer's disease by inhibiting in a subject hyperphosphoralation characteristic of Alzheimer's disease by a kinase which binds a compound of Formula I comprising:administering to a subject in need of such treatment the compound of Formula I as follows: wherein Z is O or 2H,R1 is H, OH, CO2R9, CONHR9, CH2OR9, or CONR9R10; R2 is H or OH; R3 is H or OH; R4 is H or OH; R5 is H, OH, NR9R10, NHCOR9, OCOR9, OCR9, halide, COOR9, or CONR9R10; R6 is H, OH, NR9R10, NHCOR9, OCOR9, OCR9, halide, COOR9, or CONR9R10; R7 is H, OH, O or halide; R8 is H, OH, halide or nothing (when R7 is O); R9 is an alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons or H; R10 is an alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons or H in an effective amount to inhibit the kinase.