Patent ID: 8937048
Filing Date: 2015-01-20
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a disease or condition associated with abnormal angiogenesis in a subject, comprising administering to the subject a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, wherein the compound comprises the formula: R 1 -[VEGF-Peptide]-R 2 , and wherein [VEGF-Peptide] is a peptide having the sequence: wherein R R X X X X X X the peptide may be covalently linked to an antibody directly or via an intermediate linker connected to an N-terminus amino group or C-terminus carboxyl group of the peptide or the side chain of a linking residue selected from the group consisting of K, R, Y, C, T, S, homocysteine, homoserine, Dap, and Dab; where the linking residue is at one of residue positions 1, 2, 3, 4, 9, 10, 12, 14, 17 or the C-terminus residue.