Patent ID: 6153707
Filing Date: 2000-11-28
Classification: A61M,B01D,B01J,C08F,Y10T

Abstract:
A method of producing a material for purification of physiological fluids of organism, comprising steps of providing a porous hydrophobic divinylbenzene copolymer with surface exposed vinyl group, which has a size, a shape, and a structure providing removal of toxic compounds from physiological liquids, chemically modifying the surface exposed vinyl groups so as to form different surface exposed groups which are hydrophilic and biocompatible; and performing chemical modification of the surface exposed vinyl groups in a medium with a content of an organic substance which is efficient for preventing endotoxins contamination of the polymer wherein the modification of the copolymers is performed by a method selected from the group consisting of (A) grafting hydrophobic polymer chains by a radical polymerization of 2-hydroxyethyl methacrylate, N-vinylpyrrolidone or N-vinylcaprolactam (B) oxidation of the vinyl groups to epoxy groups with subsequent reaction of the epoxy groups with water, ethylene glycol, amines or 2-aminoethanol and (C) depositing high-molecular weight hermicompatible poly(trifluoroethyloxy)phosphazene onto the surface of the polymeric beads.