Patent ID: 6093717
Filing Date: 2000-07-25
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR47## or a pharmaceutically acceptable salt thereof, wherein Y.sup.1 and Y.sup.2 are independently selected from the group consisting ofhydrogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,C.sub.3-7 cycloalkyl,halogen, andtrifluoromethyl;A is ##STR48## W is hydrogen,R.sup.1,R.sup.1 OCO,R.sup.1 CO,R.sup.1 SO.sub.2,R.sup.1 (CH.sub.2).sub.n NHCO, or(R.sup.1).sub.2 CH(CH.sub.2).sub.n NHCO,wherein n is 0-4;R.sup.1 isR.sup.2,R.sup.2 (CH.sub.2).sub.m C(R.sup.12).sub.2, where m is 0-3, and each R.sup.12 can be the same or different,(R.sup.2)(OR.sup.2)CH(CH.sub.2).sub.p, where p is 1-4, ##STR49## R.sup.2 C(R.sup.12).sub.2 (CH.sub.2).sub.m, wherein m is 0-3, and each R.sup.12 can be the same or different, wherein (R.sup.12).sub.2 can also form a ring with C represented by C.sub.3-7 cycloalkyl,R.sup.2 CH.sub.2 C(R.sup.12).sub.2 (CH.sub.2).sub.q, wherein q is 0-2, and each R.sup.12 can be the same or different, wherein (R.sup.12).sub.2 can also form a ring with C represented by C.sub.3-7 cycloalkyl,(R.sup.2).sub.2 CH(CH.sub.2).sub.r, where r is 0-4 and each R.sup.2 can be the same or different, and wherein (R.sup.2).sub.2 can also form a ring with CH represented by C.sub.3-7 cycloalkyl, C.sub.7-12 bicylic alkyl, or C.sub.10-16 tricylic alkyl,R.sup.2 O(CH.sub.2).sub.p, wherein p is 1-4,R.sup.2 CF.sub.2 C(R.sup.12).sub.2,(R.sup.2 CH.sub.2)(R.sup.2 CH.sub.2)CH, orR.sup.2 (COOR.sup.6)(CH.sub.2).sub.r, where r is 1-4;R.sup.2 isphenyl, unsubstituted or substituted with one or more of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R.sup.7, where R.sup.7 is C.sub.1-4 alkyl, or SO.sub.2 NH.sub.2,naphthyl,biphenyl,C.sub.1-7 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,amino,phenyl,naphthyl,C.sub.3-7 cycloalkyl,CF.sub.3,N(CH.sub.3).sub.2,--C.sub.1-3 alkylphenyl,--C.sub.1-3 alkylnaphthyl, orpyridylCF.sub.3,C.sub.3-7 cycloalkyl, unsubstituted or substituted with phenyl or naphthyl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl;R.sup.3, R.sup.4 and R.sup.6 are independently selected from the group consisting ofhydrogen,C.sub.1-4 alkyl,C.sub.3-7 cycloalkyl, ortrifluoromethyl;X ishydrogen, orhalogen;Z is CH.sub.2, S, or SO.sub.2 ;R.sup.12 ishydrogen,phenyl, unsubstituted or substituted with one or more of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, COOH, CONH.sub.2,naphthyl,biphenyl,C.sub.1-4 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,amino,phenyl,naphthyl, orCF.sub.3,C.sub.3-7 cycloalkyl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl.