Patent ID: 6255306
Filing Date: 2001-07-03
Classification: A61P,C07D

Abstract:
A compound of formula ##STR13##R.sup.2 is hydrogen and R.sup.3 is selected from, (C.sub.1 to C.sub.6)alkyl; --(C.sub.1 to C.sub.3)alkylaryl, --(C.sub.1 to C.sub.3)alkylheteroaryl --NH(C.dbd.O)R.sup.6, --(C.dbd.O)NHR.sup.6, --O(C.dbd.O)R.sup.6, --(C.dbd.O)OR.sup.6, --(C.dbd.O)R.sup.6, OR.sup.6, --SO.sub.n R.sup.6, --NHSO.sub.n R.sup.6, --SO.sub.n NHR.sup.6, aryl, and heteroaryl;R.sup.4 is hydrogen;R.sup.5 is hydrogen or --CH.sub.3 ;R.sup.6 is hydrogen, (C.sub.1 to C.sub.6)alkyl, --(C.sub.1 to C.sub.3)alkylaryl, --(C.sub.1 to C.sub.3)alkylheteroaryl, aryl, heteroaryl, and --(CH.sub.2)--Y--R.sup.7 ;R.sup.7 is hydrogen, (C.sub.1 to C.sub.6)alkyl, --(C.sub.1 to C.sub.3)alkylaryl, --(C.sub.1 to C.sub.3)alkylheteroaryl, --(C.dbd.O)NHR.sup.8, --(C.dbd.O)OR.sup.8, --(C.dbd.O)R.sup.8, --OR.sup.8, --SO.sub.n R.sup.8, --SO.sub.n NHR.sup.8, aryl, and heteroaryl;R.sup.8 is hydrogen, (C.sub.1 to C.sub.3)alkyl, aryl, heteroaryl, --(C.sub.1 to C.sub.3)alkylaryl and --(C.sub.1 to C.sub.3)alkylheteroaryl;Y is oxygen, --SO.sub.n --, or NH;n is 0, 1, or 2;and said heteroaryl groups and the heteroaryl moieties of said alkylheteroaryl groups are selected from pyridyl and indolyl;and said heteroaryl groups and the heteroaryl moieties of said alkylheteroaryl groups may optionally be substituted with from one to three substituents independently selected from (C.sub.1 to C.sub.4)alkyl, halogen, hydroxy, cyano, carboxamido, nitro, (C.sub.1 to C.sub.4)alkoxy, --(C.sub.1 to C.sub.3)alkylaryl, --(C.sub.1 to C.sub.3)alkylheteroaryl, aryl, heteroaryl, and --(CH.sub.2)--Y--R.sup.7 ;and said aryl groups and the aryl moieties of said alkylaryl groups are phenyl and may optionally be substituted with one to three substituents independently selected from (C.sub.1 to C.sub.4)alkyl, halogen, hydroxy, cyano, carboxamido, nitro, and (C.sub.1 to C.sub.4)alkoxy;provided that where R.sup.3 is --(C.dbd.O)OR.sup.6, R.sup.6 is --(C.sub.1 to C.sub.3)alkylaryl; or a pharmaceutically acceptable salt thereof.