Patent ID: 8278263
Filing Date: 2012-10-02
Classification: A61K,A61P,C07K,C12N,C12Y,G01N

Abstract:
1. A method of inhibiting mTOR by inhibiting the interaction between PLD2 and raptor, thereby inhibiting the formation of a complex of PLD2 and mTOR through raptor (PLD/raptor/mTOR complex), comprising the step of inactivating a raptor binding domain of PLD2 by substitution of one or more amino acids of SEQ ID NO: 4 comprised in the raptor binding domain of PLD2, with at least one other amino acid selected from the group consisting of alanine, isoleucine, leucine, methionine, phenylalanine, proline, tryptophan, valine, asparagine, cysteine, glutamine, glycine, serine, threonine, tyrosine, aspartic acid, glutamic acid, arginine, histidine, and lysine.