Patent ID: 6867313
Filing Date: 2005-03-15
Classification: A61P,C07C,C07F,Y02P

Abstract:
1. A vitamin D 3 derivative expressed by the following general formula (1) or pharmaceutically permissible solvates thereof, wherein, R 01 and R 02 are each independently a hydrogen atom, a trimethylsilyl group, a triethylsilyl group, a t-butyldimethylsilyl group, an acetyl group, a methoxymethyl group or a tetrahydro-4H-pyran-2-yl group; Z is one out of the following formulae (1-3) and (1-4), in the above formulae (1-3) and (1-4), m is an integer of 0 to 2; n is an integer of 0 to 2; Q expresses >C(—F)—R R A and B are identical to or different from each other, and they express a hydrogen atom or a hydroxyl group, or together express a single bond and form a double bond in cooperation with the single bond formed between the carbon atoms to which each of A and B is attached, respectively; X and Y together express a carbonyl group in cooperation with the carbon atom to which they are bonded, one of them is a hydrogen atom and the other is a hydroxyl group, or one of them is a hydrogen atom and the other is a C R R R D and E express each a hydrogen atom, D is a hydroxy group and E expresses a hydrogen atom; D and E together express a single bond and express a double bond in cooperation with the single bond formed between the carbon atoms to which each of D and E is attached, respectively, or E and R with the proviso that the following compound (a) is excluded, (a) a compound in which the groups of one combination out of R