Patent ID: 8309536
Filing Date: 2012-11-13
Classification: A61C,A61L,A61P

Abstract:
1. An implantation method for releasing an active agent in at least two phases, the method comprising the steps of: providing an implant having a porous portion; coating the porous portion with a calcium phosphate compound; contacting the implant with a bisphosphonate compound to form: (i) a bisphosphonate layer chemically bound to the calcium phosphate compound at the surface of the porous portion, and (ii) bisphosphonate molecules non-chemically attached inside pores of the porous portion; implanting the implant at least partially within a subject; burst-releasing, in a first release phase, the non-chemically attached bisphosphonate molecules in the subject upon contact with body fluids of the subject; and slowly releasing, in a second release phase, the chemically bound bisphosphonate layer in the subject upon contact with the body fluids.