Patent ID: 6444656
Filing Date: 2002-09-03
Classification: C07H

Abstract:
A nucleotide analogue according to formula (I): or a pharmaceutically acceptable salt, a pharmaceutically acceptable ester, or a pharmaceutically acceptable salt of an ester wherein:n is 0; X is O; Q is CH2; U is C&boxH;CH2 or CH(Ra); Ra is OH, CN, halogen, N3, or NH2; Z is (CH2)m wherein m is 1; R1 and R1â€² are each independently selected from H, C1-6 alkyl, phosphate or diphosphate; and R2 is â€ƒwherein x is oxygen or sulfur; y is oxygen or sulfur; R3 and R4 are each independently selected from hydrogen, hydroxyl, amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-10 acyl, or C6-12 aryl; R5 and R6 are each independently selected from hydrogen, F, Cl, Br, I, hydroxyl, methyl or amino; R7 is H, F, Cl, I, Br, hydroxyl, amino or the formulas â€ƒwherein: q is an integer selected from 1 to 4; R18 is selected from H, COOH, C(O)NH2, OH, SH, NH2, NO2,or C1-6 alkyl; R17 is H or a C1-6 alkyl; and R8 and R9 are each independently chosen from hydrogen, hydroxyl, amino, substituted amino, halogen, azido or methyl; provided that when R2 is adenine Ra, if present, is CN, halogen, N3, or NH2.