Patent ID: 6569901
Filing Date: 2003-05-27
Classification: C07C

Abstract:
A compound of formula (I) whereinX is hydrogen or X is C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl or heterocyclyl each of which is optionally substituted with one or more substituents selected from halogen, perhalomethyl, hydroxy, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, hydroxy, C1-6-alkoxy, C1-6-alkylthio, aryl, aryloxy, arylthio, acyl, aralkyl, aralkoxy, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, C1-6-alkylthio, cyano, amino, C1-6-alkylamino, C1-6-dialkylamino, carboxy or C1-6-alkylester; and Y is hydrogen or Y is C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, C4-12-alkenynyl, aryl, heteroaryl, aralkyl or heteroaralkyl each of which is optionally substituted with one or more substituents selected from halogen, C1-6-alkyl, perhalomethyl, hydroxy, aryl, heteroaryl, amino, carboxy or C1-6-alkylester; and Z is hydrogen, halogen, hydroxy or Z is C1-6-alkyl or C1-6-alkoxy each of which is optionally substituted with one or more substituents selected from C1-6-alkoxy, halogen, hydroxy, carboxy, amino or cyano; and Q is O, S or NR5, wherein R5 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl, aralkyl or heteroaralkyl and wherein R5 is optionally substituted with one or more substituents selected from halogen, hydroxy, C1-6-alkoxy, amino or carboxy; and Ar is arylene, heteroarylene or a divalent heterocyclic group each of which can be optionally substituted with one or more substituents selected from C1-6-alkyl, aryl or C1-6-alkoxy each of which can be optionally substituted with halogen, hydroxy, carboxy or C1-6-alkylester; and R1 is hydrogen, hydroxy or halogen; or R1 forms a bond together with R2; and R2 is hydrogen or C1-6-alkyl; or R2 forms a bond together with R1; and R3 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl, aryl, aralkyl, C1-6-alkoxyC1-6-acyl, heterocyclyl, heteroaryl or heteroaralkyl groups optionally substituted with one or more substituents selected from halogen, perhalomethyl, hydroxy, cyano, carboxy or C1-6-alkylester; and R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl or aryl; n is an integer ranging from 0 to 3; and m is an integer ranging from 0 to 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or any tautomeric forms, stereoisomers, mixture of stereoisomers including a racemic mixture, or polymorphs.