Patent ID: 6121260
Filing Date: 2000-09-19
Classification: A61P,C07D

Abstract:
A method of treating conditions susceptible to modulation of NPY receptors which comprises administering to a patient suffering from such conditions an effective dose of a compound of the formula: ##STR8## or a pharmaceutically acceptable salt where R.sub.1 is an unsubstituted or mono, di or trisubstituted aryl group wherein said aryl group is mono or bicyclic, in which case only the ring bound to the imidazole ring must be aromatic, and said aryl group is carbocyclic or contain up to 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur and said substituents are individually selected from the group consisting of halogen, trihalomethyl, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms (which alkyl or alkoxy groups themselves are unsubstituted or substituted by an amino or a mono- or di-alkyl amino group or by a mono- or di-alkarylamino group or by an acyl group), straight or branched chain lower thioalkoxy having 1-6 carbon atoms, acyloxy groups, amino, amino mono or disubstituted with straight or branched chain lower alkyl having 1-6 carbon atoms, said alkyl groups being unsubstituted or substituted with a hydroxy or amino group, alkyl, aryl or alkaryl amide groups the nitrogen atom of which is bound to the aryl group, mono or disubstituted carbamyl wherein the CO group is bound to the aryl group and wherein each substituent is lower alkyl or aryl lower alkyl, mono or di-alkyl carbamates having up to 6 carbon atoms in each alkyl group or mono or diaryl carbamates or any 2 adjacent substituents bound to the aryl group form a group of the formula --X--(CH.sub.2).sub.n --Y--(CH.sub.2).sub.m --Z-- where X, Y and Z are either a direct bond, oxygen, sulfur, or NR where R is hydrogen or lower alkyl and n and m are 1, 2 or 3;one of R.sub.2 and R.sub.3 is selected from the group consisting of hydrogen, hydroxymethyl, alkoxymethyl having up to 6 carbon atoms in each alkoxy group, straight or branched chain lower alkyl having 1-6 carbon atoms, cyano, or a carboxylic or carboxylate ester group wherein the esterifying group contains up to six carbon atoms;the other of R.sub.2 and R.sub.3 is an aryl group which is either unsubstituted or mono, di or trisubstituted wherein said aryl groups are mono or bicyclic (in which case only the ring bound to the imidazole ring need be aromatic) and may be carbocyclic or contain up to 2 hetero atoms and said substituents are individually selected from the group consisting of halogen, trihalomethyl, cyano, hydroxy, straight or branched chain lower alkoxy having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms (which alkyl and alkoxy groups themselves are unsubstituted or substituted by an amino group, or a mono- or di-alkylamino group, a nitrogen-containing ring, a mono- or di-alkaryl group or by an acyl group or a carbamate), straight or branched chain lower thioalkoxy having 1-6 carbon atoms, acyloxy groups, amino, amino mono or disubstituted with straight or branched chain lower alkyl having 1-6 carbon atoms (said alkyl groups being unsaturated or substituted with a hydroxy or amino group), alkyl, aryl and alkaryl amide groups the nitrogen atom of which is bound to the aryl group, mono or disubstituted carbamyl wherein the CO group is bound to the aryl group and wherein each substituent is lower alkyl or aryl lower alkyl, mono- or di-alkyl carbamates having up to 6 carbon atoms in each alkyl group or mono or diaryl carbamates additionally any two adjacent substituents of the aryl group may be represented as --X--(CH.sub.2).sub.n --Y--(CH.sub.2).sub.m --Z-- where X, Y and Z are either a direct bond, oxygen, sulfur, or NR where R is hydrogen or lower alkyl and n and m are 1,2 or 3.