Patent ID: 8575332
Filing Date: 2013-11-05
Classification: A61K,C08B,C08J

Abstract:
1. A method for preparing crosslinked polysaccharide microparticles having an average particle diameter of 0.01 μm to 150 μm, which method comprises the following steps: a) preparing a dilute solution containing (1) a polysaccharide derivative having at least one crosslinkable functional group in a range of 0.1 to 5% (w/v) and (2) a crosslinking agent; b) dispersing the solution by spraying to form microparticulate droplets; and c) concentrating the solution contained in the droplets to facilitate a crosslinking addition reaction of the polysaccharide derivative between a mercapto group and an unsaturated C—C bond, thereby providing microparticles having an average particle diameter of 0.01 μm to 150 μm; wherein steps b) and c) are carried out in a spray drying procedure; wherein the polysaccharide derivative is a hyaluronic acid derivative comprising at least one repeating unit represented by Formula (I); wherein X R R Y Y Q R Y Q and the crosslinking agent is a compound having two or more unsaturated C—C bond-containing groups; or the polysaccharide derivative is a hyaluronic acid derivative comprising at least one repeating unit represented by Formula (II): wherein X R R Y Y Y Q R Q wherein the method is performed so as to crosslink the hyaruronic acid derivative during concentration and drying.