Patent ID: 8679541
Filing Date: 2014-03-25
Classification: A61K

Abstract:
1. A device for the oral delivery of a pharmaceutical to a subject, the device comprising a hollow tube having two ends, and a plurality of particles comprising a pharmaceutically active agent, the device further comprising a plurality of particle containment elements adapted for restraining the particles within the hollow tube while the subject imbibes an aqueous fluid comprising the pharmaceutically active agent by flowing the aqueous fluid through the tube in contact with the particles, wherein: the particles are spatially arranged within the device to achieve a specific flow resistance not greater than about 50 Torr/mm within the device, and wherein each of the particles comprises an outer layer formed over an inner core, the inner core comprising an inert material, the outer layer comprising the pharmaceutically active agent embedded in a matrix, the matrix being erodable when contacted with an aqueous medium and the inner core being insoluble when contacted with an aqueous medium.