Patent ID: 8258343
Filing Date: 2012-09-04
Classification: A61K,A61Q

Abstract:
1. A method of inhibiting an enzyme in a human suffering from a condition of skin degradation selected from the group consisting of challenged skin from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof comprising administering an effective amount of a composition comprising a compound of Formula I or a salt thereof: Wherein, R X is selected from -NH—peptide, —NH-C R R wherein said enzyme is selected from a from a group consisting of Tyrosinase, Matrix Metalloprotease, Phenylalanine Oxidase, Collagenase and Elastase”.