Patent ID: 7314720
Filing Date: 2008-01-01
Classification: G01N

Abstract:
1. An in vitro method for assessment of a liver tissue sample from a subject, to determine presence of NASH in said subject, said method comprising: a) detecting and quantifying in said liver tissue sample the level of each of the following proteins: apoliprotein A1 (APA1), mitochondrial ATPase 13 subunit (ATPB), leukotriene A4 hydrolase (LKHA), keratin 18 (K1CR), guanidinoacetate N-methyltransferase (GAMT), superoxide dismutase (SODC), albumin (ALBU), antioxidant protein 2 (AOP2) (isoforms 1 and 2), prohibitin 1 (PHB1), methionine adenosyl transferase (MAT), long-chain acyl-CoA dehydrogenase (ACDL), selenium binding protein (SBP); b) comparing the results obtained in step a) with normal reference values for said proteins in liver tissue; and c) based on said comprising, determining the presence of NASH in said subject.