Patent ID: 8993574
Filing Date: 2015-03-31
Classification: A01N,A61K,A61P,C07D

Abstract:
1. A pharmaceutical combination comprising a combination of a first antifungal agent which is a pyrrole derivative of formula (I) or a pharmaceutically acceptable salt thereof, with a second antifungal agent: wherein: R1 represents hydrogen, unsubstituted or substituted C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —COR′ or —SO A1 represents a C3-C6 cycloalkyl or an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; A2 and A3 are the same or different and represent C3-C6 cycloalkyl or an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; A4 is an unsubstituted or substituted 5- to 12-membered heterocyclyl group wherein 1 or 2 ring carbon atoms are replaced with a group selected from >C(═O), >S(═O) L1 represents a bond, a C1-C6 alkylene group in which none, one, two or three —CH L2 represents —NR′—, —O—, —CO—, —OCO, —OCONR′R″—, —CONR′R″— or —SO L3 represents a bond or a C1-C4 alkylene group in which none, one or two —CH n is 1 or 2; R6 represents hydrogen or C1-C4 alkyl; R5 represents an unsubstituted or substituted group selected from C6-C10 aryl, a 5- to 12-membered heterocyclyl group, C1-C8 alkyl and C3-C6 cycloalkyl, halogen or a group of formula —B1-B2 or —B3; B1 represents an unsubstituted or substituted C6-C10 aryl group; B2 represents an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; B3 is an unsubstituted or substituted 5- to 12-membered heterocyclyl group where 1 or 2 ring carbon atoms are replaced with a group selected from >C(═O), >S(═O) R2 and R3 independently represent C6-C10 aryl, a 5- to 12-membered heterocyclyl group, C3-C6 cycloalkyl, hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO R4 represents hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —OR′, —CONR′R″, —COR′, —CN, —NO Y represents C1-C8 alkylene, C2-C8 alkenylene or C2-C8 alkynylene; Z represents halogen, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO R′ and R″ independently represent hydrogen, C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl; wherein an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl group or moiety can be substituted or unsubstituted; and wherein: a substituted alkyl, alkenyl or alkynyl group or moiety is a said alkyl, alkenyl or alkynyl group or moiety which is substituted with up to three substituents selected from halogen, hydroxy, amino, (C1-C4 alkyl)amino, di(C1-C4 alkyl)amino, C1-C4 alkoxy, —S(C1-C4 alkyl), —CO a substituted cycloalkyl group is a said cycloalkyl group which is substituted with up to three substituents selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, Z and —Y—Z; a substituted aryl or heterocyclyl group or moiety is a said aryl or heterocyclyl group or moiety which is substituted with up to three substituents selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, Z and —Y—Z.