Patent ID: 6133455
Filing Date: 2000-10-17
Classification: C07C,C07D

Abstract:
A process for the preparation of a 2-aryl-5-(perfluoroalkyl)pyrrole compound having the structural formula I ##STR28## wherein W is hydrogen or C.sub.m F.sub.2m+1 ;Y is CN, NO.sub.2 or CO.sub.2 R;R is C.sub.1 -C.sub.4 alkyl;m and n are each independently an integer of 1, 2, 3, 4, 5, 6, 7 or 8; ##STR29## L is hydrogen or halogen; M and Q are each independently hydrogen, halogen, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkylsulfonyl or when M and Q are on adjacent positions they may be taken together with the carbon atoms to which they are attached to form a ring in which MQ represents the structure --OCH.sub.2 O--, --OCF.sub.2 O-- or --CH.dbd.CH--CH.dbd.CH--;R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, halogen, NO.sub.2, CHO or R.sub.2 and R.sub.3 may be taken together with the atoms to which they are attached to form a ring in which R.sub.2 R.sub.3 is represented by the structure ##STR30## R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen, halogen, CN or NO.sub.2 ; andX is O or Swhich process comprises reacting an N-(arylmethylene)-1-chloro-1-(perfluoroalkyl)methylamine compound having the structural formula II ##STR31## wherein A and n are as described above with a dieneophile compound having the structural formula III or an .alpha.,.beta.-dihalo compound having the structural formula IV ##STR32## wherein W and Y are as described above and Z is Cl, Br or I, and a base in the presence of a solvent.