Patent ID: 7550145
Filing Date: 2009-06-23
Classification: A61K,A61P,C12N

Abstract:
1. A composition comprising: (1) dsRNA, wherein the dsRNA is polyriboinosinic-polyribocytidylic acid (poly[rI-rC]), polyriboguanylic-polyribocytidylic acid (poly[rG-rC]) or polyriboadenylic-polyribouridylic acid (poly[rA-rU]); and (2) an HCV E1E2 polypeptide that comprises a sequence of amino acids with at least 90% sequence identity to the contiguous sequence of amino acids depicted at positions 20-637 of SEQ ID NO:2, with the proviso that the HCV E1E2 polypeptide comprises the amino acid sequence of SEQ ID NO:4 at a position corresponding to amino acids 218-238 of SEQ ID NO:2, wherein said polypeptide elicits an immune response against HCV, wherein said dsRNA and/or said HCV E1E2 polypeptide are adsorbed to a microparticle, and further wherein the immune response to the composition is increased as compared to the immune response to a composition comprising the HCV E1E2 polypeptide without the dsRNA and/or the microparticle.