Patent ID: 6458781
Filing Date: 2002-10-01
Classification: C07C,C07D

Abstract:
A compound having the structural Formula I or the pharmaceutically acceptable salts, thereof, whereinX is â€”NH(CH2)3â€”; each R1 and R2 are independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, â€”(CH2)nphenyl, â€”(CH2)nsubstituted phenyl wherein the substituents on the phenyl group are selected from the group consisting of halogen, C1-C8 alkyl, â€”CN, â€”CF3, â€”NO2, â€”NH2, â€”NHC1-C8 alkyl, â€”N(C1-C8 alkyl)2, â€”OC1-C8 alkyl, and â€”OH, â€”C3-C7 cycloalkyl-(CH2)nâ€”, C3-C7 heterocycle-(CH2)nâ€” wherein one of C3-C7 is replaced with a heteroatom selected from the group consisting of N, O, or S and wherein the heterocycle is saturated or unsaturated, monocyclic or bicyclic, R1 and R2 together with the nitrogen atom to which they are both attached form a heterocycloalkyl group selected from piperidinyl and morpholinyl, with the proviso that R1 and R2 cannot simultaneously be hydrogen; n is 0 to 6 R3 is hydrogen, C1-C6 alkyl, phenyl, substituted phenyl selected from the substituents consisting of halogen, C1-C8 alkyl, â€”CN, â€”CF3, â€”NO2, â€”NH2, â€”NHC1-C8 alkyl, â€”N(C1-C8 alkyl)2, â€”OC1-C8 alkyl, and â€”OH, benzyl, substituted benzyl selected from the substituents consisting of halogen, C1-C8 alkyl, â€”CN, â€”CF3, â€”NO2, â€”NH2, â€”NHC1-C8 alkyl, â€”N(C1-C8 alkyl)2, â€”OC1-C8 alkyl and â€”OH, or â€”(CH2)nâ€”C3-C7 cycloalkyl; R4 is hydrogen or C1-C6 alkyl, with the proviso that R3 and R4 cannot simultaneously be hydrogen; or R3 and R4 together with the carbon atom to which they are attached form a C3-C7 cycloalkyl ring; each R5 and R6 are substituted phenyl selected from the substituents consisting of halogen, C1-C8 alkyl, â€”CN, â€”CF3, â€”NO2, â€”NH2, â€”NHC1-C8 alkyl, â€”N(C1-C8 alkyl)2, â€”OC1-C8 alkyl, and â€”OH; and R7 is C1-C6 alkyl, phenyl, or C3-C7 heterocycloalkyl wherein one of C3-C7 is replaced with a heteroatom selected from the group consisting of N, O, or S and wherein the heterocycle is saturated or unsaturated, monocyclic or bicyclic.