Patent ID: 7227002
Filing Date: 2007-06-05
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody or antibody fragment being low or not immunogenic in humans and recognizing the human 17-1A antigen as expressed on the surface of tumor cells, the antibody or antibody fragment being further characterized as comprising a human VH chain and a human VL chain wherein at least said VH chain is a VH sequence of unprimed mature human B-lymphocytes and comprises three CDRs encoded by nucleotides 91 to 105, 148 to 198 and 292 to 351 within nucleotides 1 to 381 of SEQ ID NO: 143 and said VL chain is a VL sequence of a naturally occurring human B cell repertoire and comprises three CDRs encoded by nucleotides 70 to 102, 148 to 168 and 265 to 294 within nucleotides 1 to 321 of SEQ ID NO: 141.