Patent ID: 9150621
Filing Date: 2015-10-06
Classification: A61K,A61P,C07K,C12N,C12P,C12Y

Abstract:
1. A method of eliciting an immune response to a bacterial pathogen of the genus Neisseria in a host, said method including the step of administering to said host an immunogenic composition comprising an isolated mutant Neisseria nitrite reductase polypeptide that is not glycosylated, wherein the mutant Neisseria nitrite reductase polypeptide comprises an amino acid sequence lacking a carboxy-terminal serine-containing tetrapeptide repeat AASA (SEQ ID NO: 113) of a corresponding wild-type Neisseria nitrite reductase glycoprotein and elicits a more immunologically effective immune response compared to the corresponding wild-type Neisseria nitrite reductase glycoprotein, to thereby elicit an immune response to said bacterial pathogen in said host.