Patent ID: 6680344
Filing Date: 2004-01-20
Classification: A61K,A61Q

Abstract:
A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by the structure: and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein:n is an integer from 1 to 3; R1 and R2 are each, independently, selected from the group consisting of hydrogen lower alkyl, and hydroxy; with the provisos that when R1 is doubly-bonded oxygen R2 is nil; and when R1 is doubly-bonded sulfur R2 is nil; R4 is selected from the group consisting of hydrogen, lower alkyl, and cycloalkyl; R6 and R9 are each, independently, selected from the group consisting of hydrogen and lower alkyl; R7 and R8 are each, independently, selected from the group consisting of hydrogen, lower alkyl, substituted phenyl and substituted benzyl, wherein the substituted phenyl and substituted benzyl may be optionally mono-, di-, or tri-substituted, independently, by a substituent selected from the group consisting of hydroxy, â€”COOH, lower alkyl, lower alkoxy, nitro, amino, alkytamino, dialkylamino, trifluoromethyl and cyano; with the proviso that at least one of R7 and R8 is not hydrogen; R10 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, and acyl; and R11 is selected from the group consisting of hydrogen, lower alkyl, and cycloalkyl.