Patent ID: 6632825
Filing Date: 2003-10-14
Classification: A61P,C07C,C07D

Abstract:
A compound of formula: wherein:Ra1 is a heterocycloalkyl, or heteroaryl group, provided that Ra1 is not a substituted pyrrolidinyl, where the heterocycloalkyl, or heteroaryl group is unsubstituted or substituted with one or more suitable substituents; Rc is a substituent having the formula: â€ƒwherein: Rf and Rg are each independently H or lower alkyl; m is 1; p is 1; A1 is CH; A2 is C(Rh)(Ri), where each Rh, and Ri is independently H or a lower alkyl group; each A3 present is C(Rh)(Ri); where each Rh and Ri is independently H or lower alkyl; when p is 1, A4 is N(Rk), where each Rk is H, alkyl, aryl, or acyl; where each dotted line in the ring depicts a single bond; Rd is H, halogen, hydroxyl or an alkyl, alkoxy or alkylthio group, where the alkyl, alkoxy or alkylthio group is unsubstituted or substituted with one or more suitable substituents; Rb is H or an alkyl group, unsubstituted or substituted with one or more suitable substituents; Z and Z1 are each independently H, F, an alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, where the alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl group is unsubstituted or substituted with one or more suitable substituents, â€”C(O)Rnâ€”CO2Rnâ€”CN, â€”C(O)NRnRo, â€”C(O)NRnORo, â€”C(S)Rn, â€”C(S)ORnâ€”C(S)NRnRo, â€”C(&boxH;NRn)Ro, â€”C(&boxH;NRn)ORo, â€”NO2, â€”SORo, â€”SO2Rn, â€”SO2NRnRo, â€”SO2(NRn)(ORo), â€”SONRn, â€”SO3Rn, â€”PO(OR)n)2, â€”PO(ORn)(ORo), â€”PO(NRnRo)(ORp), â€”PO(NRnRo)(NRpRq), â€”C(O)NRnNRoRp, or â€”C(S)NRnNRoRp, where Rn, Ro, Rp and Rq are each independently H or an alkyl, cycloalkyl, aryl, heterocycloalkyl, acyl or thioacyl group, where the alkyl, cycloalkyl, aryl, heterocycloalkyl, acyl or thioacyl group is unsubstituted or substituted with one or more suitable substituents, or where any two of the Rn, Ro, Rp and Rq, taken together with the atoms to which they are bonded, form a heterocycloalkyl group, which may be optionally substituted, or Z and Rd, together with the atoms to which they are bonded, form a cycloalkyl or heterocycloalkyl group, where Z and Rd are as defined above except for moieties that cannot form the cycloalkyl or heterocycloalkyl group, or Z and Z1, together with the atoms to which they are bonded, form a cycloalkyl or heterocycloalkyl group, where Z and Z1 are as defined above (except for moieties that cannot form the cycloalkyl or heterocycloalkyl group); or a prodrug, pharmaceutically acceptable salt, pharmaceutically active metabolite, or pharmaceutically acceptable solvate thereof.