Patent ID: 6573268
Filing Date: 2003-06-03
Classification: C07D

Abstract:
A method of treating diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes said diabetes caused by insulin resistance or impaired glucose tolerance comprising administering a therapeutically effective amount of a compound of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates where one of X, Y or Z represents C&boxH;O or C&boxH;S and one of the remaining of X, Y and Z represents C&boxH; and the other of the remaining X, Y and Z represents C&boxH;C; R1, R2 and R3 are substituents either on X, Y or Z or on a nitrogen atom and are the same or different and represent hydrogen, halogen, hydroxy or nitro, or optionally substituted groups selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aralkyl, heterocyclyl, heteroaryl, heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aminoalkyl, aryloxy, alkoxycarbonyl, alkylamino, alkoxyalkyl, thioalkyl, alkylthio or carboxylic acid and its derivatives or sulfonic acid or its derivatives with the provision that when R1, R2 or R3 is on a nitrogen atom it does not represent hydrogen, halogen, nitro, carboxy or sulfonic acid groups; or any two of R1, R2 and R3 along with the adjacent atoms to which they are attached may form a substituted or unsubstituted cyclic structure of 4 to 7 atoms with one or more double bonds which may be carbocyclic or may contain one or more heteroatoms selected from oxygen, nitrogen and sulfur, the linking group represented by (CH2)nâ€”Oâ€” may be attached either through nitrogen atom or through X, Y or Z where n is an integer ranging from 1-4; Ar represents an optionally substituted divalent aromatic or heterocyclic group; R4 represents hydrogen, halogen or lower alkyl group or fornms a bond together with the adjacent group A; A represents a nitrogen atom or a group CR5 where R5 represents hydrogen, halogen or lower alkyl group or R5 forms a bond together with R4; B represents an oxygen atom or a sulfur atom when A is CR5 and B represents an oxygen atom when A is a nitrogen atom and a pharmaceutically acceptable carrier, diluent or excipient to a patient in need thereof.