Patent ID: 7368452
Filing Date: 2008-05-06
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A method of inhibiting the replication of hepatitis C virus, the method comprising supplying a hepatitis C viral NS3 protease inhibitory amount of the pharmaceutical composition comprising a compound of Formula I or II: Wherein A is independently selected from hydrogen; —(C═O)—O—R G is independently selected from —OH, —O—(C L is absent or independently selected from —S—, —SCH X and Y taken together with the carbon atoms to which they are attached form a cyclic moiety selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; W is absent, or independently selected from —O—, —S—, —NH—, or —NR Z is independently selected from hydrogen, —CN, —SCN, —NCO, —NCS, —NHNH wherein R wherein R wherein R R j=0, 1, 2, 3, or 4; m=0, 1, or 2; and s=0, 1 or 2.