Patent ID: 7465549
Filing Date: 2008-12-16
Classification: A61K,A61P,G01N,Y02A

Abstract:
1. A method of identifying a compound or an agent that binds a levetiracetam binding site (LBS) of a synaptic vesicle protein 2 (SV2) protein comprising; a) obtaining a cell-free or membrane-free SV2 protein comprising a LBS wherein the SV2 protein is SV2A or SV2C; b) incubating the SV2 protein with a compound or an agent and levetiracetam (LEV) or an analog or derivative thereof that binds a LBS on an SV2 protein; and c) determining if the compound or agent competes with LEV or an analog or derivative thereof for binding to the LEV binding site, thereby identifying a compound or an agent that binds the LBS of the SV2 protein.