Patent ID: 9023368
Filing Date: 2015-05-05
Classification: A61K,A61P

Abstract:
1. A delayed release drug formulation suitable for delivering a drug to the colon of a subject, the formulation comprising a particle with a core and a coating for the core, the core comprising a drug and the coating comprising a homogenous mixture of a first material which is susceptible to attack by colonic bacteria and a second material which is a film-forming acrylate polymer having a pH threshold at about pH 5 or above which is the pH below which the second material is insoluble and at or above which the second material is soluble and dissolution of the second material is triggered by surrounding medium in the colon, wherein the first material is selected from the group consisting of amylopectin; and starch having no more than 75 wt % amylose; wherein a ratio of the first material to the second material in the mixture is from 15:85 to less than 99:1, wherein the coating has a thickness as measured by theoretical weight gain of from about 4% to about 35%, and wherein release of the drug is delayed until the colon of the subject.