Patent ID: 8674081
Filing Date: 2014-03-18
Classification: A61K,A61P,C07K

Abstract:
1. An engineered nucleic acid construct encoding a polypeptide comprising an array of epitopes, wherein the array comprises one or more copies of CTL epitope PSMA 288-297 (SEQ ID NO:6), or a cross-reactive analogue differing from SEQ ID NO:6 by only 1-3 substitutions, and one or more copies of CTL epitope PRAME 425-433 (SEQ ID NO:5), or a cross-reactive analogue differing from SEQ ID NO:5 by only 1-3 substitutions, wherein the polypeptide does not comprise a whole PSMA antigen (SEQ ID NO: 19), and wherein the polypeptide does not comprise a whole PRAME antigen (SEQ ID NO: 20).