Patent ID: 6291237
Filing Date: 2001-09-18
Classification: A61K,A61P,C07K,G01N,Y02A,Y10S

Abstract:
An isolated polynucleotide comprising a nucleotide sequence, or its reverse complement, wherein:the nucleotide sequence encodes a mutant form of a TGF.beta. receptor RII;the nucleotide sequence comprises at least one mutation; andthe mutation is selected from the group consisting of a two base pair insertion of GT which occurs in a six base pair repeat sequence GTGTGT corresponding to nucleotides 1931-1936 of SEQ ID NO:10, a deletion of one A base pair from a ten base pair poly A sequence corresponding to nucleotides 709 to 718 of SEQ ID NO:10, and a deletion of two A base pairs from a ten base pair poly A sequence corresponding to nucleotides 709 to 718 of SEQ ID NO:10.