Patent ID: 8753806
Filing Date: 2014-06-17
Classification: A01N

Abstract:
1. A method for organ preservation in donation after cardiac death (DCD) or brain death donors, comprising the steps of: after cardiac or brain death in a subject is pronounced, administering intravenously to said subject a sufficient quantity of an organ protection solution which has one or more cell impermeant molecules selected from the group consisting of sorbitol, gluconate, trehalose, raffinose, lactobionate, and maltitol, and at least one of said one or more cell impermeant molecules is present at a concentration of at least 60 mM, which are pharmaceutically acceptable and can cross a capillary endothelium and into an interstitial space in said subject, wherein said one or more cell impermeant molecules preferentially load into extracellular fluid in an extracellular fluid compartment of said subject and increase a theoretical extracellular fluid osmolarity of said subject by 40-100 mM without entering one or more of endothelial and parenchymal cells within a treatment period of 30 to 120 minutes; and preventing or reducing cell swelling of organs of said subject using said one or more cell impermeant molecules to exert osmotic effects on one or more of endothelial cells and parenchymal cells, wherein prevention or reduction of cell swelling continues until harvesting of one or more organs from said subject.