Patent ID: 9173890
Filing Date: 2015-11-03
Classification: A61K,A61P

Abstract:
1. A composition, comprising: a first sustained-release carrier and a second sustained-release carrier, at least one of the first sustained-release carrier and the second sustained-release carrier comprising (1) a coating to facilitate targeting of the carrier and (2) a sustained release material comprising a cardiovascular targeting molecule comprising CRPPR (SEQ ID NO: 11) or a polyanhydride material comprising CPPP (SEQ ID NO: 12); and a non-complexed apolipoprotein A-I (apo A-I) synthetic mimetic peptide and a non-complexed phospholipid, the non-complexed apo A-I synthetic mimetic peptide is encapsulated within the first sustained-release carrier and the non-complexed phospholipid is encapsulated within the second different sustained-release carrier such that upon sustained-release from the respective first and second sustained-release carriers, in situ complexing of the non-complexed apo A-I and non-complexed phospholipid occurs, and wherein the first sustained-release carrier and the second sustained release carrier are suspended within a hydrogel solution to form a dispersion, and the apo A-I synthetic mimetic peptide comprises an amino acid sequence including one of: (i) an 18-mer synthetic peptide comprising DWFKAFYDKVAEKFKEAF (SEQ ID NO: 1); and (ii) the reverse sequence of SEQ ID NO: 1.