Patent ID: 6541473
Filing Date: 2003-04-01
Classification: A61K,A61P,A61Q,C07C,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:R is a (C3-C8)cycloalkyl or (C5-C8)cycloalkenyl ring substituted by â€”N(R1)CONR2R3 wherein R1 and R2 are independently selected from hydrogen, (C1-C6)alkyl, and aryl(C1-6)alkyl, and R3 is hydrogen, (C1-C6)alkyl, aryl(C1-C6)alkyl, or aryl; â€”N(R4)COR5 wherein R4 is hydrogen, (C1-C6)alkyl, aryl(C1-C6)alkyl-, or OH and R5 is (C7-C10)alkyl, aryl, aryl(C1-C6)alkyl-, â€”O-aryl, CF3, heterocycloalkyl, â€”(C1-C6)alkylheterocycloalkyl, â€”(C2-C7)alkenylheterocycloalkyl, heteroaryl, â€”(C1-C6)alkyl heteroaryl, â€”(C2-C7)alkenylheteroaryl, â€”(C2-C7)alkenylaryl, â€”(C2-C7)alkenylCOaryl, â€”(C1-C6)alkylN(R4)CO-aryl, â€”(C1-C6)alkylCO-aryl, â€”(C1-C6)alkylhydroxyaryl, â€”(C1-C6)alkyl-X-aryl, (C2-C7)alkenyl, benzyhydryl, 5-hydroxyoxoindanyl, or tetrahydronaphthalenyl, wherein X is O, S, SO, SO2 or NR1; â€”N(R1)OCOaryl; &boxH;CHCO2R1; &boxH;CHCONR1R2; &boxH;CHCN; &boxH;NNHSO2R6 wherein R6 is aryl; â€”N(O)&boxH;CHR6; â€”OC(O)NR1R7 wherein R7 is aryl, aryl(C1-C6)alkyl-, â€”(C1-C6)alkylCO2(C1-C6)alkyl, â€”CO2(C1-C6)alkyl, â€”CO2aryl, or â€”CO2(C1-C6)alkylaryl; amino(C1-C6)alkylarylCO2â€”; or â€”OC(O)OR8 wherein R8 is (C1-C6)alkyl, aryl(C1-C6)alkyl, or aryl; with the proviso that the cycloalkenyl ring is not aromatic.