Patent ID: 6107346
Filing Date: 2000-08-22
Classification: C07C,Y10S

Abstract:
A method of inhibiting hyperlipidemia comprising administering to a mammal in need thereof an effective amount of a compound of formula I(b): ##STR8## where R.sup.a, R.sup.1a, and R.sup.2a are independently at each occurrence hydrogen, hydroxy, --O(C.sub.1 -C.sub.4 alkyl), --OCO(C.sub.1 -C.sub.4 alkyl), --OCOAr, --OCO.sub.2 (C.sub.1 -C.sub.4 alkyl), --OCO.sub.2 Ar, or C.sub.3 -C.sub.6 cycloalkoxy;Ar is phenyl or substituted phenyl;X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--;R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, or a moiety of the formula (a), (b), or (c): ##STR9## wherein R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently at each occurrence hydrogen, fluoro, chloro, bromo, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.4 alkoxy;or a pharmaceutically acceptable salt or solvate thereof.