Patent ID: 6083945
Filing Date: 2000-07-04
Classification: A61K,C07D

Abstract:
A cyclic urea compound which has the structure: ##STR12## wherein a) X is a saturated or unsaturated, substituted or unsubstituted 6-membered carbocycle;b) R is a covalent bond;c) Y is a saturated or unsaturated, substituted or unsubstituted 5-membered heterocycle, wherein said heterocycle has one or two heteroatoms selected from O, S or N;d) R.sub.1, R.sub.2, and R.sub.3 are substituents on the X moiety and are independently selected from the group consisting of H, Cl, F, Br, NH.sub.2, CF.sub.3, OH, SO.sub.3 H, CH.sub.3, SO.sub.2, NH, COOH, alkoxy, alkoxycarbonyl, alkyl, hydroxyalkyl, carboxyalkyl, amino alkyl, acylamino, and acyloxy;e) L is a linking moiety and is selected from the group consisting of alkylamino, alkenylamino, alkylimino, alkenylimino, and acylamino, wherein the carbon-containing end of L is bound, through R, at X; and wherein the nitrogen atom of L is bound to the nitrogen atom at the 3-position of the cyclic urethane ring moiety;f) R.sub.4 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkylacyl, and heteroalkyl;g) A is a substituted or unsubstituted; saturated or unsaturated, straight-chain or branched C.sub.1 -C.sub.8 heteroalkyl; or a substituted or unsubstituted, saturated or unsaturated, heterocycle having 5-, 6- or 7-members and one or two heteroatoms selected from O, N or S; and heteroalkyl A and heterocycle A have at least one nitrogen atom, which nitrogen atom is adjacent to R.sub.4; andh) R.sub.5 is a substituted or unsubstituted C.sub.2 alkyl;and the pharmaceutically-acceptable salts and esters thereof.