Patent ID: 8884019
Filing Date: 2014-11-11
Classification: A61K,A61P,C07B,C07D

Abstract:
1. A method for producing an amorphous of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or salt thereof, which comprises: subjecting a racemate of a compound of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole to an optical resolution so that an R-enantiomer of the compound is obtained; adding a solvent comprising ethanol to the obtained R-enantiomer of the compound so that the R-enantiomer of the compound dissolves in the solvent and an R-enantiomer solution is formed; optionally concentrating the R-enantiomer solution so as to form a concentrate; further adding hexane to the R-enantiomer solution or the concentrate; and evaporating the resulting solution to dryness.