Patent ID: 6472391
Filing Date: 2002-10-29
Classification: A61K,A61P,C07D

Abstract:
A nitrogen-containing heterocyclic compound represented by formula (I): wherein V represents an oxygen atom or a sulfur atom; W represents 1,4-piperazinediyl, or 1,4-homopiperazinediyl in which carbons on the ring may be substituted by 1-4 alkyl groups which may be the same or different; R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted heteroarylalkyl group; R2 represents a substituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted heteroarylalkyl group, â€”COR10 (wherein R10 has the same significance as R1) or â€”SO2R11 (wherein R11 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted heteroarylalkyl group); R3, R4, R5 and R6 independently represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a nitro group, a cyano group, â€”OR12 {wherein R12 has the same significance as R10, or represents â€”COR13 (wherein R13 has the same significance as R10) or â€”SO2R14 (wherein R14 has the same significance as R11)}, â€”NR15R16 {wherein R15 has the same significance as R10, and R16 has the same significance as R10, or represents â€”SO2R17 (wherein R17 has the same significance as R11) or (wherein X1 represents an oxygen atom or sulfur atom; and R18 has the same significance as R10, or represents â€”OR19 (wherein R19 has the same significance as R11) or â€”NR20R21 (wherein R20 and R21 independently have the same significance as R10, or R20 and R21 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)); or R15 and R16 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing heterocyclic group}, {wherein m represents an integer of 0-2; and when m is 0, R22 has the same significance as R10; when m is 1, R22 has the same significance as R11; and when m is 2, R22 has the same significance as R11 or represents â€”OR23 (wherein R23 has the same significance as R10) or â€”NR24R25 (wherein R24 and R25 independently have the same significance as R10, or R24 and R25 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)} or â€”COR26 {wherein R26 has the same significance as R10, or represents â€”OR27 (wherein R27 has the same significance as R10) or â€”NR28R29 (wherein R28 and R29 independently have the same significance as R10, or R28 and R29 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group)}; or any adjoining two of R3, R4, R5 and R6 are combined together to represent methylenedioxy or ethylenedioxy; or any adjoining two of R3, R4, R5 and R6 are combined together with the two adjoining carbon atoms to form a substituted or unsubstituted phenyl ring; or any of R3 and R4, R4 and R5, or R5 and R6 are combined together with the two adjoining carbon atoms to represent {wherein A represents an oxygen atom, a sulfur atom or â€”NR30â€” (wherein R30 has the same significance as R10); and Q1 has the same significance as R10, or represents â€”NR31R32 (wherein R31 and R32 independently have the same significance as R10, or R31 and R32 are combined together with the adjoining nitrogen atom to represent a substituted or unsubstituted nitrogen-containing alicyclic heterocyclic group) or â€”SR33 (wherein R33 has the same significance as R10)}, or (wherein R34 and R35 independently have the same significance as R10; and Q2 represents an oxygen atom, a sulfur atom or &boxH;Nâ€”CN), or wherein R36 has the same significance as R10);X, Y, Z each represent a nitrogen atom, or a pharmaceutically acceptable salt thereof wherein the alkyl is C1-16 and straight-chain or branched, the alicyclic alkyl is C3-12, the alkenyl is C2-16 and straight-chain or branched, the alkynyl is C2-16 and straight-chain or branched, and the aralkyl is C7-15; and wherein the substituted alkyl, the substituted alkenyl, the substituted alkynyl, the substituted alicyclic alkyl group, the substituted alicyclic heterocyclic group, the substituted nitrogen-containing alicyclic heterocyclic group, the substituted nitrogen-containing heterocyclic group, the substituted aryl group, the substituted aralkyl group, the substituted heteroaryl group, the substituted heteroarylalkyl group and the substituted phenyl ring each have 1 to 3 substituents which are the same or different.