Patent ID: 6821998
Filing Date: 2004-11-23
Classification: A61K,A61P,C07D

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound having the formula: or a pharmaceutically acceptable salt of the compound, whereinthe subscripts m and n are each independently integers from 1 to 2; R1 and R2 are each independently selected from the group consisting of (C1-C4)alkyl, wherein the alkyl portions are optionally substituted with OH or (C1-C4)alkoxy groups; or R1 and R2 are optionally combined with the nitrogen atom to which each is attached to form a ring selected from the group consisting of aziridine, azetidine, pyrrolidine, piperidine, imidazoline, piperazine and morpholine, each of said rings being optionally substituted with from one to three substituents selected from the group consisting of (C1-C4)alkyl, phenyl, phenyl(C1-C4)alkyl, hydroxy, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl and di(C1-C4)alkylanxino(C1-C4)alkyl; and R3 and R4 are each independently selected from the group consisting of (C1-C4)alkyl, or when taken together with the nitrogen atom to which each is attached, form a ring selected from the group consisting of aziridine, azetidine, pyrrolidine and piperidine which is optionally substituted with one or two (C1-C4)alkyl groups; and wherein the pharmaceutical composition is formulated as an oral, topical, parenteral. or rectal preparation, or as an intraocular implant.