Patent ID: 6140368
Filing Date: 2000-10-31
Classification: C07C,C07D,C09B

Abstract:
A method for treating a retroviral infection in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a naphthol compound, or a pharmaceutically acceptable salt thereof, having the structure: ##STR209## wherein R.sub.1 and R.sub.2 each is selected from a group consisting of substituted aryl (C.sub.6 -C.sub.12), unsubstituted aryl (C.sub.6 -C.sub.12), substituted heteroaryl (C.sub.2 -C.sub.12) and unsubstituted heteroaryl (C.sub.1 -C.sub.12), wherein the heteroatom is nitrogen, bound via an azo or amide group, provided that neither R.sub.1 nor R.sub.2 contains a --SO.sub.3 H group, Y and Y' each is selected from the group consisting of --SO.sub.3 H, --COOH esters of --SO.sub.3 H and --COOH, and tetrazolyl, and X is a substantially rigid linker, wherein the linker is:(a) derived from the group consisting of urea, thiourea, oxalyl, malonyl, carbamate, succinyl, and vinylogous amide;(b) an aryl or heteroaryl, where the heteroatom is nitrogen or oxygen; or(c) a squarate or a cage structure.