Patent ID: 6306165
Filing Date: 2001-10-23
Classification: A61L

Abstract:
An implantable medical device having at least one hydrophobic surface, said surface having a bio-active coating bound thereto, said bioactive coating containing a polymer backbone bound via an amide or an amine linkage to a first end of a hydrophilic, amine-terminated spacer, said spacer having at least one amine group at each of its first and second ends, said hydrophilic spacer being covalently bound to a bio-active molecule via its second end, said hydrophilic spacer further being repelled by said hydrophobic surface such that the bio-active molecule is extended away from said hydrophobic surface, wherein said bio-active coating further comprises a polymer structure defined by a bio-compatible polymeric backbone and at least one pendant moiety selected from the group consisting of: ##STR16##wherein R.sup.1 is ##STR17##R.sub.2 is a spacer group selected from the group consisting of oxygenated polyolefins, aliphatic polyesters, polyamino acids, polyamines, hydrophilic polysiloxanes, hydrophilic polysilazanes, hydrophilic acrylates, hydrophilic methacrylates, linear polysaccharides and lightly branched polysaccharides; and R.sup.3 is a bio-active agent selected from the group consisting of antithrombogenic agents, antibiotics, antibacterial agents, antiviral agents, pharmaceutical salts thereof and mixtures thereof.