Patent ID: 6416968
Filing Date: 2002-07-09
Classification: A61P,C07K,C12Q,G01N

Abstract:
A method of selecting a test molecule comprising:preparing a wild-type biological sample at a first pH, wherein the biological sample contains wild-type Helicobacter; preparing a UreI-deficient biological sample at the first pH, wherein the biological sample contains UreI-deficient Helicobacter; adding a test molecule at the same concentration to each of the wild-type and UreI-deficient biological samples; reducing the pH of the wild-type and the pH of the UreI-deficient biological samples to a second pH; comparing the growth or survival of the wild-type and UreI-deficient biological samples in the first pH and the second pH; and selecting a test molecule that reduces the growth or survival of the wild-type Helicobacter to a greater extent than the survival of the UreI-deficient Helicobacter.