Patent ID: 6331542
Filing Date: 2001-12-18
Classification: A61P,C07C,C07D,C12N,C12Q,G01N

Abstract:
A compound according of Formula IX: ##STR69##wherein:J is C(O), or SO.sub.2 ;Ar is phenyl, or naphthyl; optionally substituted by one or more of Ph--C.sub.0-6 alkyl, Het--C.sub.0-6 alkyl, C.sub.1-6 alkoxy, Ph--C.sub.0-6 alkoxy, Het--C.sub.0-6 alkoxy, OH, (CH.sub.2).sub.1-6 N.sup.58 R.sup.59, or O(CH.sub.2).sub.1-6 NR.sup.58 R.sup.59 ;R.sup.44 is CH(R.sup.53)NR.sup.45 R.sup.54, CH(R.sup.55)Ar, or C.sub.5-6 alkyl;R.sup.45, R.sup.48, R.sup.49, R.sup.50, and R.sup.51 are independently H, C.sub.1-6 alkyl, Ar--C.sub.0-6 alkyl, or Het--C.sub.0-6 alkyl;R.sup.47 is H, C.sub.1-6 alkyl, Ar--C.sub.0-6 alkyl, pyridinylmethoxy or Het--C.sub.0-6 alkyl;R.sup.52 is Ar, Het, CH(R.sup.56)Ar, CH(R.sup.56)OAr, N(R.sup.56)Ar, C.sub.1-6 alkyl, or CH(R.sup.56)NR.sup.46 R.sup.57 ;R.sup.53 is C.sub.2-6 alkyl, Ar--C.sub.0-6 alkyl, or Het--C.sub.0-6 alkyl; orR.sup.53 and R.sup.45 may be connected to form a pyrrolidine or piperidine ring;R.sup.54 and R.sup.57 are independently R.sup.47, R.sup.47 C(O), R.sup.47 C(S), or R.sup.47 OC(O);R.sup.56, R.sup.58, and R.sup.59 are independently H, C.sub.1-6 alkyl, Ar--C.sub.0-6 alkyl, or Het--C.sub.0-6 alkyl;or a pharmaceutically acceptable salts, hydrates or solvates thereof.