Patent ID: 6589527
Filing Date: 2003-07-08
Classification: A61K,C07K,C12N

Abstract:
A method of recruiting an antibody-mediated effector function to an antigenic target in an individual, the method comprising:binding a multi-specific binding molecule, said multi-specific binding molecule comprising at least two antibody variable domains each with an antigen binding site wherein one antigen binding site has binding specificity for antibodies native to the serum of said individual (â€œnative antibodiesâ€ ) and wherein the other said antigen binding site has non-covalent binding specificity for the antigenic target, to said native antibodies and said antigenic target and causing or allowing the native antibodies thus bound to mediate their effector function, wherein said native antibodies which are bound include antibodies which do not necessarily possess specificity for said antigenic target.