Patent ID: 6642368
Filing Date: 2003-11-04
Classification: A61K,A61P,C12N

Abstract:
An isolated nucleic acid molecule at least 90% identical to a nucleic acid molecule selected from the group consisting of:(a) a nucleic acid molecule consisting of a nucleotide sequence encoding the amino acid sequence of caspase-12S as shown in FIG. 9 (SEQ ID NO: 14); (b) a nucleic acid molecule consisting of a nucleotide sequence encoding the amino acid sequence of caspase-12S as encoded by the cDNA clone contained in ATCC Deposit No. 209710; (c) a nucleic acid molecule consisting of the nucleotide sequence of caspase-12S as shown in FIG. 9 (SEQ ID NO:13); (d) a nucleic acid molecule consisting of a nucleotide sequence encoding caspase-12&Dgr; (amino acid residues 95 to 419 of SEQ ID NO:2); and (e) a nucleic acid molecule consisting of a nucleotide sequence encoding caspase-12&Dgr;2 (amino acid residues 145 to 419 of SEQ ID NO:2), wherein said nucleic acid encodes a polypeptide that increases apoptosis.