Patent ID: 6451800
Filing Date: 2002-09-17
Classification: A61P,C07D

Abstract:
A compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: whereinA represents (i) a saturated or unsaturated heterocyclic group represented by the following formula: wherein Het represents pyrimidine, tetrahydropyrimidine, imidazole, or benzimidazole, which is optionally substituted by C1-6 alkyl or amino optionally substituted by C1-6 alkyl, C1-6 alkyl substituted by an unsaturated five- to seven-membered carbocyclic group, C1-6 alkoxycarbonyl, or C1-6 alkoxycarbonyl substituted by an unsaturated five- to seven-membered carbocyclic group, or (ii) a group represented by formula â€ƒwherein R1, R2, and R3, which may be the same or different, represent a hydrogen atom, C1-6 alkyl, C2-6 alkenyl or C1-6 alkyl substituted by an unsaturated five- to seven-membered carbocyclic group, X and Z represent N; R4 represents C1-6 alkyl or an oxygen atom; R5 represents C1-6 alkyl, C1-6 alkoxy, a halogen atom, amino or nitro, wherein C1-6 alkyl is optionally substituted by C1-6 alkoxy or hydroxyl; Q represents >C&boxH;O or >CH2; R6 represents a hydrogen atom, C1-6 alkyl, C2-6 alkenyl, or C1-6 alkyl substituted by an unsaturated five- to seven-membered carbocyclic group; R7 represents a hydrogen atom, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or C1-6 alkyl substituted by an unsaturated five- to seven-membered carbocyclic group; R8 represents a hydrogen atom, C1-6 alkyl, C2-6 alkenyl, C1-6 alkyl substituted by an unsaturated five- to seven-membered carbocyclic group, or amino, wherein amino is optionally substituted by C1-6 alkyl, C1-6 alkoxycarbonyl, alkylsulfonyl, benzenesulfonyl in which the phenyl portion is optionally substituted by C1-6 alkyl, phenyl optionally condensed with the phenyl portion, carboxyl, hydroxyl, nitro, amino, saturated or unsaturated five- to seven-membered carbocyclic group, C1-6 alkylamino or a halogen atom, aralkyloxycarbonyl, or group â€”C(&boxH;O)â€”(CH2)sâ€”C(&boxH;O)â€”NHR11 wherein s is an integer of 0 to 4 and R11 represents a hydrogen atom or hydroxyl; R9 represents a hydrogen atom or C1-6 alkyl; m is an integer of 0 to 2; n is an integer of 0 or 1; p is 2; and q is 1.