Patent ID: 6395781
Filing Date: 2002-05-28
Classification: A61K,A61P,Y10S

Abstract:
A method of reducing a patient's vascular diameter, comprising the step of supplying to a patient in need of such reduction an effective amount of a 20-HETE agonist wherein the 20-HETE agonist is a compound of the formula: wherein R1 is selected from the group consisting of carboxylic acid, phenol, amide, imide, sulfonamide, sulfonimide, active methylene, 1,3-dicarbonyl, alcohol, thiol, amine, tetrazole and other ionizable or heteroaryl groups, R2 is selected from the group consisting of carboxylic acid, phenol, amide, imide, sulfonamide, sulfonimide, active methylene, 1,3-dicarbonyl, alcohol, thiol, amine, tetrazole and other ionizable or heteroaryl groups, W is a carbon chain (C1 through C25) and may be linear, cyclic, or branched and may comprise heteroatoms, Y is a carbon chain (C1 through C25) and may be linear, cyclic, or branched and may comprise heteroatoms, sp<3 Center is selected from the group consisting of vinyl, aryl, heteroaryl, cyclopropyl, and acetylenic moieties, X is an alkyl chain that may be linear, branched, cyclic or polycyclic and may comprise heteroatoms, m is 0, 1, 2, 3, 4 or 5, and n is 0, 1, 2, 3, 4 or 5.