Patent ID: 6288075
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR21##or a racemate, an enantiomer, a diastereoisomer or an inorganic or organic acid salt thereof,in which:R.sub.1 is a sulphur atom;R.sub.2 is a hydrogen atom or an alkyl radical;--R.sub.3 --R.sub.4 --R.sub.5 -- is a chain having formula --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH(R.sub.7)--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH(R.sub.8)--, --CH.sub.2 --CH(R,)--CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CO--, --CH.sub.2 --CF.sub.2 --CH.sub.2 --, or --CH.sub.2 --CF.sub.2 --CH(OH)--;R.sub.6 is a polyfluoroalkyl, polyfluoroalkoxy or polyfluoroalkylthio radical;R.sub.7 is an alkyl, --CH.sub.2 OH, --CH.sub.2 --SO.sub.2 -alk or --CH.sub.2 --NR.sub.11 R.sub.12 radical;R.sub.8 is an alkyl radical, a hydroxyl, an --CH.sub.2 OH, --NR.sub.11 R.sub.12, --CH.sub.2 --NR.sub.11 R.sub.12, --S-alk, --SO-alk, --SO.sub.2 -alk, thienyl, furyl, or phenyl radical or a phenyl radical substituted with a substituent chosen from: halogen atoms, alkyl radicals and alkoxy radicals;R.sub.9 is an alkyl or --CH.sub.2 OH radical;R.sub.11 is a hydrogen atom, an alkyl, a --CO-alk or --CO--CF.sub.3 radical;R.sub.12 is a hydrogen atom or an alkyl radical;or R.sub.11 and R.sub.12 form, with the nitrogen atom to which they are attached, a saturated or unsaturated 5- or 6-membered heterocycle which may or may not contain another heteroatom chosen from: nitrogen, oxygen and sulphur; wherein said heterocycle is unsubstituted or substituted with at least one substituent chosen from: alkyl radicals, phenyl radicals, halophenyl radicals and phenylalkyl radicals;alk is an alkyl radical;wherein, unless otherwise indicated, said alkyl and alkoxy radicals and portions thereof have from 1 to 6 straight- or branched-chain carbon atoms.