Patent ID: 6117442
Filing Date: 2000-09-12
Classification: A61K,A61P

Abstract:
A delivery device for the controlled release of a therapeutically active agent over a prolonged period of time, said device comprisinga core comprising an androgen as said therapeutically active agent, anda membrane encasing said core, wherein said membrane is made of an elastomer, characterized in that the elastomer is a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units,wherein 1 to approximately 50% of the substituents attached to the Si-atoms in the siloxane units of the elastomer are 3,3,3-trifluoropropyl groups; andwherein the elastomer is made of either(i) a mixture comprising a) a non-fluorosubstituted siloxane-based polymer and b) a fluorosubstituted siloxane-based polymer, said polymer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units; or(ii) a single siloxane-based polymer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, wherein said polymer or mixture of polymers are crosslinked to form the elastomer.