Patent ID: 7338660
Filing Date: 2008-03-04
Classification: A01K,A61K,A61N,A61P,C07K

Abstract:
1. A method of treating cancer in a human, comprising the step of administering to the human an effective amount of a monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody comprises: (a) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 42, and (b) a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-34, 50-56, and 89-97 of SEQ ID NO: 44.