Patent ID: 9034308
Filing Date: 2015-05-19
Classification: A61K,A61Q

Abstract:
1. A method for treating a hypersensitive tooth to reduce the sensitivity of the tooth, comprising: contacting the hypersensitive tooth with an oral care composition comprising, from 0.1 percent by weight to 50 percent by weight of water soluble phosphate ester salts as an agent effective to reduce tooth sensitivity, wherein all water soluble phosphate ester salts of the composition consist of one or more phosphate monoester salts according to structure (I) and one or more phosphate diester salts according to structure (II), wherein the molar ratio of the one or more phosphate monoester salts to the one or more phosphate diester salts is from 70:30 to 92:8, wherein the phosphate monoester salt according to structure (I) has a phosphate head group of structure (IA) and a hydrophobic tail of structure (IB) wherein the phosphate diester salt according to structure (II) has a phosphate head group of structure (IIA) and hydrophobic tails of structures (IIB) and (IIC) wherein: R n and m are each individually 2 to 4, a and b are each individually 0 to 20, one of Z Z at least one anti-caries agent selected from the group consisting of sodium fluoride and sodium monofluorophosphate wherein sodium trimetaphosphate is an optional additional anti-caries agent; and wherein the composition has an absence of calcium compounds; wherein the composition has an absence of strontium salts; wherein the phosphate head groups of the one or more water soluble phosphate monoester salts and the one or more water soluble phosphate diester salts anchor to calcium hydroxyapatite tooth structure of the hypersensitive tooth, the hydrophobic tails separate from the respective anchored phosphate head groups by hydrolysis, and the phosphate head groups after hydrolysis are fixed in place in the calcium hydroxyapatite tooth structure by reaction with calcium in saliva of an oral cavity in which the hypersensitive tooth is located.