Patent ID: 8987195
Filing Date: 2015-03-24
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein each Z is independently either N or C—R A is a selected from the group consisting of J is selected from the group consisting of a direct bond, R L is NH; G is selected from the group consisting of  wherein R each R R R T is selected from the group consisting of O, (CH Q is —(CR each R  wherein X provided that two R 4 groups can join together to form methylene dioxy; each Aryl is independently phenyl optionally substituted with 1 or 2 R each Het is independently either (a) 4-, 5- or 6-membered saturated or unsaturated monocyclic ring with 1 or 2 heteroatom ring atoms independently selected from the group consisting of N, O and S; or (b) 8-, 9- or 10-membered saturated or unsaturated bicyclic ring with 1, 2, or 3 heteroatom ring atoms independently selected from the group consisting of N, O and S, provided that said Het is optionally substituted with 1 or 2 R each R —(C 0 -C 5 alkyl)-S(O) 2 —(C 0 -C 5 alkyl)-(C 3 -C 8 cycloalkyl), Aryl, and Het; provided that two R A groups present on adjacent carbon atoms can together with the adjacent carbon atoms form a C 3 -C 6 cycloalkyl; each R each R alternatively, with respect to A and R alternatively, with respect to A and R alternatively, with respect to R