Patent ID: 6080743
Filing Date: 2000-06-27
Classification: A61P,C07D,C07F

Abstract:
A 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivative of formula I ##STR13## wherein one of the radicals R.sub.1 and R.sub.2 is a group R.sub.5 and the other is a group of formula --alk--N(R.sub.8)--X--R.sub.7 (Ic)or --alk--N.sup.+ (R.sub.8)(R.sub.9)--X--R.sub.7 A.sup.- (Id),R.sub.3, R.sub.4 and R.sub.5 are each independently of the others hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro,R.sub.7 is hydrogen; an aliphatic, cycloaliphatic or heterocycloaliphatic radical; cyano; acyl derived from carbonic acid or from a semiester or semiamide of carbonic acid, from sulfuric acid or from an aliphatic or aromatic sulfonic acid or from phosphoric acid or from a phosphonic acid ester; amino that is unsubstituted or aliphatically or araliphatically substituted and/or substituted by aliphatic, araliphatic or aromatic acyl; or an aromatic or heteroaromatic radical,R.sub.8 is hydrogen; an aliphatic or araliphatic radical; or acyl derived from an aliphatic or araliphatic carboxylic acid or from an aliphatic or araliphatic semiester of carbonic acid,R.sub.7, R.sub.8 and R.sub.9, together with X and the nitrogen atom bonding R.sub.8, R.sub.9 and X, form an unsubstituted or substituted quaternary heteroaryl radical bonded via the quaternary nitrogen atom, with A.sup.- being the anion of a protonic acid,alk is lower alkylene, andX (unless, together with the nitrogen atom bonding R.sub.8, R.sub.9 and X, it forms part of an optionally substituted quaternary heteroaryl radical is a divalent aliphatic, cycloaliphatic or araliphatic radical or a direct bond,with the proviso that in compounds of formula I wherein R.sub.1, R.sub.3 and R.sub.4 are hydrogen and R.sub.2 is a group of formula Ic, when alk is ethylene the group --N(R.sub.8)--X--R.sub.7 is other than amino, dipropyl-amino and N-(2-phenylethyl)-N-propyl-amino,or a salt thereof.