Patent ID: 8455493
Filing Date: 2013-06-04
Classification: A61K,A61P,C07D,C12Q,G01N

Abstract:
1. At least one chemical entity chosen from compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R R wherein A is chosen from aryl, cycloalkyl and heterocycloalkyl groups, each of which groups having from 5 to 7 ring atoms including the atoms shared with the 6 membered aromatic ring and each of which groups being optionally substituted with one or more substituents independently chosen from —R a , —OR b , —O(C 1 -C 2 alkyl)O-, —SR b , guanidine, guanidine wherein one or more of the guanidine hydrogens are replaced with a lower-alkyl group, —NR b R c , halo, cyano, nitro, —COR b , —CO 2 R b , —CONR b R c , —OCOR b , —OCO 2 R a , —OCONR b R c , —NR c COR b , —NR c CO 2 R a , —NR c CONR b R c , —SOR a , —SO 2 R a , —SO 2 NR b R c , and —NR c SO 2 R a ; wherein, for each occurrence, R R R R where each optionally substituted group of R R R R R