Patent ID: 7498432
Filing Date: 2009-03-03
Classification: C07D

Abstract:
1. A process for the preparation of 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosa-4,6,13,15,21,23-hexaene (2) which comprises: (a) reacting a mixture of tris(2-aminoethyl)amine (tren) with glyoxal in the presence of water, a water miscible solvent and a tertiary amine with cooling to a temperature of about −30° C. or less, wherein the glyoxal is added slowly to the mixture, to prepare 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosa-4,6,13,15,21,23-hexaene (2) without formation of gelatinous byproducts.