Patent ID: 8563035
Filing Date: 2013-10-22
Classification: A61K,A61P

Abstract:
1. An oral tablet of at least one of dexlansoprazole, pharmaceutically acceptable salts and hydrates thereof and having a gradual release, wherein said tablet comprises: a) 5.0 to 40.0% by weight of the dexlansoprazole in powder form; b) 60.0 to 95.0% by weight of the dexlansoprazole in granule form comprising the dexlansoprazole, lactose and microcrystalline cellulose, and wherein a weight ratio of lactose to microcrystalline cellulose in said dexlansoprazole granule form is between 1:20 and 1:5 by weight; and c) a single enteric coating that dissolves at between pH 5.5 and 6.4, wherein the tablet has a release profile if orally administered in that the dexlansoprazole is gradually released after administration first in the proximal small intestine at pH 5.5 and then in the distal small intestine at pH 6.0 to 6.4.