Patent ID: 8178494
Filing Date: 2012-05-15
Classification: A61K,A61P,C07K,C08G

Abstract:
1. A pharmaceutical formulation of human growth hormone (hGH) polypeptide comprising a non-naturally encoded amino acid wherein the non-naturally encoded amino acid is substituted at a position corresponding to a position selected from the group 35, 92, 131, 134, 143, and 145 of SEQ ID NO:2 and wherein the non-naturally encoded amino acid is linked to a linear polyethylene glycol through an oxime bond and wherein the polyethylene glycol has a molecular weight of at least 20 kDa-40 kDa, wherein said formulation is liquid, and wherein the serum half-life of the PEGylated hGH is at least two-fold greater than the serum half-life of a naturally occurring, unPEGylated version of an hGH protein.