Patent ID: 8853365
Filing Date: 2014-10-07
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A binding protein comprising first and second polypeptide chains, wherein the first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker; X2 is an Fc region; and wherein the second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain; VD2 is a second light chain variable domain; C is a light chain constant domain; X1 is a linker; X2 does not comprise an Fc region; n is 0 or 1, and wherein the binding protein is capable of binding a pair of antigens selected from the group consisting of IL-1alpha and IL-1beta, wherein either the VD1 heavy and light chain variable domain or the VD2 heavy and light chain variable domain form an antigen binding domain that binds the IL-1beta antigen and comprises the amino acid sequences of SEQ ID NOs: 30 and 31 or SEQ ID NOs: 32 and 33, and wherein the other of the VD1 or VD2 heavy and light chain variable domains forms an antigen binding domain that binds the IL-1alpha antigen.