Patent ID: 7595344
Filing Date: 2009-09-29
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A compound of formula I: wherein: A represents the carbon atoms necessary to complete a saturated or unsaturated ring containing 4, 5, 6 or 7 ring atoms, said ring bearing, in addition to Ar X represents C(R Ar Ar R R R R R Ar represents phenyl or heteroaryl bearing 0-3 substituents selected from halogen, C “heterocyclyl” at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, O and S, wherein none of the constituent rings is aromatic and wherein at least one ring atom is other than C; and “heteroaryl” at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, O and S, wherein at least one of the constituent rings is aromatic and wherein at least one ring atom of said aromatic ring is other than C; or a pharmaceutically acceptable salt thereof, with the proviso that if A represents —CH 2 —CH(CO 2 R)—CO—CH 2 CH 2 — or —CH═C(CO 2 R)—CO—CH 2 CH 2 —, where R represents methyl, ethyl, n-propyl or n-butyl, and Ar 1 represents 4-methylphenyl or 4-chlorophenyl, then Ar 2 does not represent 4-halophenyl or 2,4-dihalophenyl where the halogens are independently Cl or F.