Patent ID: 9198979
Filing Date: 2015-12-01
Classification: A61K,A61P

Abstract:
1. An antibody-drug conjugate comprising a protein attached by a linker to one or more drugs, wherein the linker comprises a heterocyclic 1,3-substituted five- or six-member ring, having the following structure: wherein X and Y are, each independently, selected from the group consisting of sulphur, nitrogen and oxygen wherein n, m independently vary between 0 and 1, provided that n and m are not both 0; and wherein R1 and/or R2 are selected from the group consisting of a drug or an antibody molecule to which the linker is attached, and wherein the linker has a half-life of from about 1hour to about 50 hours in phosphate buffered saline at 37° C.