Patent ID: 7125877
Filing Date: 2006-10-24
Classification: A61K,A61P,C07D

Abstract:
1. Benzimidazole derivatives which are represented by a general formula [I-1] in which X stands for a hydrogen or halogen, B stands for a halogen, cyano or optionally fluorine-substituted lower alkyl, D stands for a group selected from a group consisting of the following formulae [D-1], wherein m1 is 0 or an integer of 1 or 2 R R  stands for a piperazine ring; R R R in which b is 0 or an integer of 1–4, R Y [list α] wherein list α is  halogen, hydroxyl, amino, mono-lower alkylamino, di-lower alkylamino, optionally fluorine-substituted lower alkyloxy, lower alkyloxycarbonyl, (lower alkyloxycarbonyl)amino, (lower alkyloxycarbonyl)lower alkylamino, carboxyl, lower alkylcarbonyl, lower alkylcarbonyloxy, (lower alkylcarbonyl)amino, (lower alkylcarbonyl)lower alkylamino, carbamoyl, mono-lower alkylcarbamoyl, di-lower alkylcarbamoyl, carbamoylamino, mono-lower alkylcarbamoylamino, di-lower alkylcarbamoylamino, (mono-lower alkylcarbamoyl)lower alkylamino, (di-lower alkylcarbamoyl)lower alkylamino, carbamoyloxy, mono-lower alkylcarbamoyloxy, di-lower alkylcarbamoyloxy, lower alkylsulfonyl, lower alkylsulfonylamino, sulfamoyl, mono-lower alkylsulfamoyl, di-lower alkylsulfamoyl, sulfamoylamino, (mono-lower alkylsulfamoyl)amino, (di-lower alkylsulfamoyl)amino, (mono-lower alkylsulfamoyl)lower alkylamino, (di-lower alkylsulfamoyl) lower alkylamino, phenyl tetrazolyl or oxadiazolyl which may optionally be substituted with lower alkyl, or their pharmaceutically acceptable salts.