Patent ID: 7179953
Filing Date: 2007-02-20
Classification: A01K,C07K,C12N,G01N

Abstract:
1. A method of preparing a composition comprising an agent that affects processing of amyloid precursor protein to beta-amyloid peptide, the method comprising: providing a transgenic rodent comprising a diploid genome comprising a comprising in operable linkage a promoter and a DNA segment encoding a human APP polypeptide comprising the Swedish mutation wherein the amino acid residues aat positions corresopnding to positions contacting the transgenic rodent with the agent; monitoring cleavage of the amyloid precursor protein polypeptide between the N-terminus of the beta amyloid peptide and the ATF-βAPP in the contacted transgenic rodent compared to the cleavage in a control transgenic rodent to indicate the agent affects the cleavage; and incorporating the agent into a composition with a pharmaceutical carrier.