Patent ID: 8999335
Filing Date: 2015-04-07
Classification: A61K,C07K,C12N,C12Q,G01N

Abstract:
1. A method of treating a subject in need of treatment thereof for multiple myeloma, comprising administering to the subject a pharmaceutical composition comprising a polyclonal or monoclonal antibody, or antibody binding fragment, that specifically binds to a TMEM154 polypeptide comprising at least one of SEQ ID NOS: 10, 5, 62 or 63, or a fragment thereof, in a pharmaceutically acceptable carrier, and a second medicament, wherein said second medicament is suitable for treatment of multiple myeloma, wherein said antibody and said second medicament are provided in a single dosage form or separately, and wherein said second medicament is selected for a synergistic effect between said antibody and said second medicament; wherein said multiple myeloma is selected from the group consisting of aggressive multiple myeloma; refractory multiple myeloma, and drug resistant multiple myeloma.