Patent ID: 6087371
Filing Date: 2000-07-11
Classification: A61P,C07D

Abstract:
An ergoline derivative of the formula I ##STR24## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is hydrogen, chlorine, bromine, methyl or C.sub.1-4 alkylthio; n is 1 or 2; the substituent at position 8 is in the .alpha. or .beta. configuration; the 5-membered heterocyclic ring represented by Het is an oxadiozole, thiadiazole or triazole group which is linked to the ergolinyl and pyridinyl groups through the carbon atoms as shown: ##STR25## and X is hydrogen, chlorine, bromine or fluorine; or a pharmaceutically acceptable acid addition salt thereof.