Patent ID: 6716845
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is selected from the group consisting of a phenyl, phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylamino and phenylmethyl residue, in which the phenyl moiety can be substituted by one or more halogen atoms, alkoxy, C1-C6 alkyl, cyano, or nitro groups; R2 is hydrogen; R3 is selected from the group consisting of hydrogen and lower alkyl, said lower alkyl group being optionally interrupted by one or more O, N or S atoms and optionally and independently being substituted by one or more substituents selected from the group consisting of hydroxyl and oxo; and R4 is selected from the group consisting of lower alkyl that optionally may be interrupted by one or more O, N or S atoms and optionally and independently being substituted by one or more substituents selected from the group consisting of hydroxyl, oxo, aryl, aralkyl, heteroaryl and acyl; or alternatively R2 and R3 together with the nitrogen atom to which they are bound may form a piperazine ring, provided that in such case R4 is not lower alkyl substituted by one hydroxyl group, or alternatively, R3 and R4 together with the nitrogen atom to which they are bound may form a piperazine ring that may be unsubstituted or substituted at the second nitrogen atom by an aryl, aralkyl or heteroaryl group; and the pharmaceutically acceptable salts and prodrugs of the compounds of formula I.