Patent ID: 9168504
Filing Date: 2015-10-27
Classification: A61K,B01J,B02C

Abstract:
1. A microparticle dispersion liquid manufacturing method comprising: a dissolving step of dissolving a poorly-soluble medicament and a dispersion stabilizer in a volatile organic solvent; and a fixing step of performing elimination by evaporation of the organic solvent, contained in a solution obtained in the dissolving step, and fixing a solid object, obtained by the organic solvent elimination, on an inner wall of a container; and an injecting step of injecting, after the fixing step, a solvent into the container containing the solid object to attain a state where the solvent is present above the solid object and the solid object is in contact with the solvent inside the container; and an irradiating step of performing, after the injecting step, repeated irradiation of the solvent with pulsed light from a top of the solvent side so that most of the energy of the pulsed light is absorbed by the solvent selectively among the solid object and the solvent inside the container to cause expansion and contraction of the solvent to occur repeatedly at the irradiated portion to generate a pressure wave in the solvent and make the pressure wave act on the solid object fixed on the inner wall to finely pulverize the solid object and thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent.