Patent ID: 7271193
Filing Date: 2007-09-18
Classification: C07D

Abstract:
1. A compound of general formula (Ic), or a stereoisomer, optical isomer, pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof wherein R R R Z is O or S; A is a saturated or unsaturated 5-membered ring and represented by any one of the general structures (i) to (v); wherein X 1 and X 2 are each independently selected from: a carbon atom and a nitrogen atom, provided that at least one of X 1 and X 2 is a nitrogen atom, wherein the nitrogen atom is at least monosubstituted by R 13 , wherein R 13 is selected from: hydrogen, unsubstituted C 1 -C 6 -alkyl, or C 1 -C 6 -alkyl substituted by halogen, hydroxyl or carboxyl, C 2 -C 6 -alkenyl, hydroxyl, C 1 -C 6 -alkoxy, C 1 -C 4 -alkylcarbonyl, toluenesulfonyl, cyano, SO 2 R 10 , —CO(CH 2 ) m R 14 and phenyl, which is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from: halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, nitro, NR 9 R 10 , SR 11 , trifluoromethyl, hydroxyl, cyano, carboxy, C 1 -C 4 -alkoxycarbonyl and —C 1 -C 4 -alkylenehydroxyl; R R R R m is an integer of 0 to 6.