Patent ID: 6566554
Filing Date: 2003-05-20
Classification: A61P,C07C

Abstract:
A compound of the general formula I whereinR1 and R3 represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)-alkoxycarbonyl, cyano, â€”CONH2, phenyl and nitro, provided that when R1 represents one substituent, it is in the ortho position, and when R1 represents more than one substituent, at least one R1 substituent is in the ortho position; R2 represents one substituent in the ortho position, said substituent being selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3) olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)-alkoxycarbonyl, cyano, â€”CONH2, phenyl and nitro; and R3 can further be hydrogen, carboxy and carbamoyl; R4 represents hydrogen, (C1-C3)alkyl, or allyl; X represents oxygen or sulphur; Q represents â€”(CO)â€”, â€”(CS)â€”, or a bond; Y represents (C5-C15)alkyl, except that when Q is a bond, Y is (C6-C15)alkyl or (C5-C15)alkyl substituted by R5; (C2-C15)olefinic group; (C3-C10)monocyclic hydrocarbon group; or phenyl; any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R5 defined below; (C1-C4)alkyl substituted by one or more substituents selected from the group R5; or a group of the formula â€”(Zâ€”O)nâ€”Z, wherein Z is a (C1-C3)alkyl, n is an integer >1; and no continuous linear sequence of atoms in the group Y exceeds 15; R5 represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, â€”COOH, â€”CONH2, â€”CONHRâ€², or COONRâ€²Râ€² wherein Râ€² represents (C1-C3)alkyl; or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.