Patent ID: 6455570
Filing Date: 2002-09-24
Classification: C07D

Abstract:
A compound having formula (1): wherein:R1 is â€”NHOH or â€”OH; R2 is hydrogen, C1-6 alkyl; R3 and R4 are selected independently from a group consisting of the side chains of the naturally occurring &agr;-amino acids, C1-6 alkyl, (CH2)nAr wherein the aryl group is optionally substituted with up to two groups independently selected from the group consisting of phenyl, hydroxy, C1-4 alkoxy, phenoxy, â€”O(CH2)mOH, C1-4 thioalkyl, halogens, nitro, cyano, C1-4 alkylsulfonyl, and C1-4 alkylsulfinyl wherein m is 1 or 2 and n is 0 to 3; R5 is hydrogen, C1-6 alkyl; R6 is OR7, NR7R8 wherein R7 and R8 taken independently are selected from a group consisting of hydrogen, C1-4 alkyl, C1-4 branched alkyl, alkyl aryl and benzyl; and, a stereoisomer, enantiomer, diastereomer, hydrate or pharmaceutically acceptable salt thereof.