Patent ID: 6670386
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A compound of the formula I whereinR1 is selected from the group consisting of hydrogen (H), cyano (â€”CN), nitro (â€”NO2), and halo; R2 is selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, arylalkyl or substituted arylalkyl, CO2R5, CONR5R5â€² and CH2OR5; R3 is selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, halo, cyano(â€”CN), NHCOR5, NHCO2R5, NHCONR5R5â€², NHSO2R5 and OR4; R4 in each functional group is independently selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, CHF2, CF3 and COR5; R5 and R5â€² in each functional group are each independently selected from the group consisting of hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, and â€”CN; W is (CR6R6â€²); R6 and R6â€² are each independently selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, halo, cyano (â€”CN), NHCOR5, NHCO2R5, NHCONR5R5â€², NHSO2R5 and OR4; X is methylene (â€”CH2â€”); Y is selected from the group consisting of oxygen(O), and sulfur(S); E is C&boxH;Z; Z is selected from the group consisting of oxygen(O), and sulfur(S); A and B are each independently selected from the group consisting of hydrogen (H), halo, cyano(â€”CN), nitro(â€”NO2), alkyl or substituted alkyl and OR4; n is an integer of 1; including all prodrug esters, pharmaceutically acceptable salts and stereoisomers thereof.