Patent ID: 6340758
Filing Date: 2002-01-22
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinR is a nitrogen heterocyclic ring selected from any one of the following rings â€ƒoptionally substituted by one or more substituents selected from: alkyl of from 1 to 4 carbon atoms, hydroxyl, alkoxy of from 1 to 4 carbon atoms, â€”CF3, â€”CN, â€”amino, â€”C(O)R11, or â€”(CH2)n-aryl of from 6 to 12 carbon atoms; or R is â€ƒand wherein R1 is H or alkyl of from 1 to 4 carbon atoms; R2 is hydrogen; R3 is hydrogen; R4 is each independently H, alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 5 to 7 carbon atoms, alkenyl of from 2 to 6 carbon atoms, halogen, haloalkyl of from 1 to 6 carbon atoms, nitro, cyano, SO2CF3, CH2SO2R7,(CH2)mCO2R7, (CH2)mCONR7R8, (CH2)mSO2NR8R9, or NHCOR7; R5 is H or alkyl of from 1 to 4 carbon atoms; R7, R8, R9, and R10are each independently selected from hydrogen, alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 5 to 7 carbon atoms, haloalkyl of from 1 to 4 carbon atoms, or â€”(CH2)mR11; R11 is alkyl or alkoxy of from 1 to 4 carbon atoms, hydroxy, or amino; m is an integer of from 0 to 4; n is an integer of from 0 to 4; Râ€² and Râ€³ are independently H, alkyl of from 1-4 carbon atoms, cycloalkyl of from 5 to 6 carbon atoms, or heterocycloalkyl of from 5-7 members with up to 4 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; or a pharmaceutically acceptable salt thereof.