Patent ID: 8519176
Filing Date: 2013-08-27
Classification: C07C

Abstract:
1. A process of preparing a compound of formula (I) or a salt thereof, wherein R R comprising: Step A: converting a compound of formula (II) to a compound of formula (III) according to reaction scheme 1: wherein the compound of Formula (I) is reacted with a suitable amount of potassium trimethylsilanolate (TMSOK) in the presence of a suitable solvent at a suitable reaction temperature for a suitable reaction time to provide the compound of formula (III), wherein said compound of formula (III) is obtained via a suitable isolation procedure; Step B: converting the compound of formula (III) to a compound of formula (IV) according to reaction scheme 2: wherein the compound of formula (III) is reacted with a suitable amount of oxalyl chloride in the presence of a suitable solvent and at a suitable reaction temperature for a suitable reaction time to form an acid chloride intermediate; and then said acid chloride intermediate is reacted with a suitable amount of alcohol at a suitable reaction temperature for a suitable reaction time to provide the compound of formula (IV), wherein said compound of formula (IV) is obtained via a suitable isolation procedure; and Step C: converting the compound for formula (IV) to a compound of formula (I) according to reaction scheme 3: wherein the compound of formula (IV) is hydrogenated in the presence of a suitable amount of a suitable catalyst, a suitable solvent and at a suitable reaction temperature to provide a compound of formula (I), wherein said compound of formula (I) is obtained via a suitable isolation procedure.