Patent ID: 8487109
Filing Date: 2013-07-16
Classification: C07B,C07C,C07D

Abstract:
1. A process for preparing a compound of formula I and/or all stereoisomeric forms of the compound of formula I, and/or mixtures of these forms in any ratio, and/or a physiologically tolerated salt of the compound of formula I, wherein J is a covalent bond; —(C —(C —(C —(C W is hydrogen atom, —(C —(C —(C —(C R1, R2, R3, R4, R5 and R6 are independent of one another identical or different and are a) hydrogen atom, b) —(C c) halogen, d) phenyloxy-, wherein phenyloxy is unsubstituted or substituted one to three times by R13, e) —(C f) —N(R15)-(C g) —(C h) —(C i) —(C j) a 3- to 7-membered cyclic residue, containing 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, wherein said cyclic residue is unsubstituted or mono-, di-, tri- or four times substituted independently of one another by R13, k) —O—CF l) —O—(C m) —NO n) —CN, o) —OH, p) —C(O)—R15, q) —C(O)—O—R16, r) —C(O)—N(R16)-R12, s) —N(R16)-R12, t) —N(R15)-SO v) —S—R15, w) —SO x) —SO y) —Si(R16)(R16)-R12, or R1 and R2, R2 and R3, R3 and R4 or R4 and R5 form together with the atoms which they are attached to a 5- or 8-membered ring, containing up to 0, 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, wherein said ring is unsubstituted or substituted one, two, three or four times by R14, R15 is hydrogen atom, —(C R16 and R12 are independently of one another identical or different and are a) hydrogen atom, b) —(C c) —C(O)—(C d) —(C e) —(C R13 is halogen, —NO R14 is halogen, —OH, ═O, —CN, —CF R17 and R18 are independently of one another identical or different and are a) hydrogen atom, b) —(C c) —(C d) —(C said process comprises reacting a compound of formula II, wherein R1, R2, R3, R4 and R5 are as defined in formula I and R7, R8, R9, R10 and R11 are a) hydrogen atom, b) —(C c) halogen, d) —(C e) —O—CF f) —NO g) —CN, h) —OH, i) —C(O)—R15, j) —C(O)—O—R16, k) —C(O)—N(R16)-R12, l) —N(R16)-R12, m) —SO n) —SO with a compound of formula III wherein J, and W are as defined in formula I, in the presence of a palladium catalyst, a base, a bidentate ligand and a protic solvent to give a compound of formula I and optionally the compound of formula I is converted to its physiologically tolerated salt.