Patent ID: 8481479
Filing Date: 2013-07-09
Classification: A61K,C12N

Abstract:
1. A nanoparticle, comprising a poly L-arginine polymer and a Factor VIIa inhibitor conjugated to or encapsulated in the poly L-arginine polymer, wherein the Factor VIIa inhibitor is which is Factor VIIa inhibitor I in which R 1 is independently selected from the group consisting of hydrogen and a NO donor at positions 3, 4, 5, and 6, which is Factor VIIa inhibitor II in which R 1 is independently selected from the group consisting of hydrogen and a NO donor at positions 3, 4, and 6 and in which R 2 is independently selected from the group consisting of hydrogen and a NO donor at positions 2, 4, 5, and 6, which is Factor VIIa inhibitor III in which R 1 is independently selected from the group consisting of hydrogen and a NO donor at positions 3, 4, 5, and 6, or which is Factor VIIa inhibitor IV in which R 1 is independently selected from the group consisting of hydrogen and a NO donor at positions 3, 4, and 5, wherein for each position in each Factor VIIa inhibitor of Factor VIIa inhibitors I, II, III, and IV, at which R and wherein for each position in Factor VIIa inhibitors II at which R 2 is independently selected as the NO donor, the NO donor is selected independently from the group consisting of R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , and R 19 .