Patent ID: 8946170
Filing Date: 2015-02-03
Classification: A61K,A61P,C12N

Abstract:
1. A hot-melt extruded, rod-shaped ocular implant comprising a small interfering RNA (siRNA) complexed with a transfection agent, wherein the transfection agent is selected from the group consisting of polylysine peptides, polyarginine peptides, R9, Pep-1 (SEQ ID NO:1), and MPG (SEQ ID NO.:2), wherein said complex is associated with a biodegradable polymeric matrix consisting essentially of a poly(D,L-lactide-co-glycolide) polymer, a poly(D,L-lactide) polymer, or both a poly(D,L-lactide-co-glycolide) copolymer and a poly(D,L-lactide) polymer, wherein said polymeric matrix is configured to release said complex into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease.