Patent ID: 6794512
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
A process for preparing a compound of formula I: or a pharmaceutically acceptable salt thereof; wherein the ring of the formula (R5)-A-(SOmR4) is selected from the group consisting of m is 2; X is >CR5; R1 is â€”CN; R2 is a radical selected from the group consisting of H, â€”NO2, â€”CN, (C2-C6)alkenyl, (C2-C6)alkenyl, (C3-C7)cycloalkyl, (C6-C10)aryl, Hâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”, (C3-C7)cycloalkyl-(C&boxH;O)â€”, (C6-C10)aryl-(C&boxH;O)â€” and (C1-C6)alkyl optionally substituted by on â€”OH group or by one to four fluoro substituents; R3 is a radical selected from the group consisting of R7 is a radical independently selected from the group consisting of C1alkyl substituted by one to three substituents of (C3-C7) cycloalkyl further substituted on any ring carbon atom by at least one (C1-C6)alkylidene substituent; R4 is (c1-C6)alkyl optionally substituted by one to four â€”OH substituents; and R5 is H; comprising reacting a compound of the formula II: wherein the ring of the formula (R5)-A-(SOmR4), m, and R1 through R5 are as defined above, and wherein R10 is a radical selected from the group consisting of halo, (C1-C6)alkyl-SO3â€”, (C6-C10)aryl-SO3â€”, (C1-C6)alkyl-SO2â€”, and (C6-C10)aryl-SO2â€”, wherein each of said (C1-C6)alkyl component of said (C1-C6)alkyl-SO3â€” and (C1-C6)alkyl-SO2â€” radicals is optionally substituted by one to six fluoro substituents; with a compound of formula R3â€”H, wherein R3 is as defined above, in the presence of a fluoride containing salt; in the presence of a solvent.