Patent ID: 6472534
Filing Date: 2002-10-29
Classification: A61P,C07D,Y02P

Abstract:
A method for the preparation of an oxazoline, from a tetrahydrofuran comprising treating the tetrahydrofuran, wherein Ra is â€”COR(1) and Rb is hydrogen, â€”COR(3), â€”SO2R(2) or a suitable hydroxyl protecting group with an oxophilic electrophilic reagent in a manner that is effective to provide the oxazoline, wherein Rb is hydrogen, â€”COR(3), â€”SO2R(2) or a suitable hydroxyl protecting group and Rc is hydrogen, â€”COR(3) or â€”SO2R(2); wherein R(1), R(2) and R(3) independently represent a substituted or unsubstituted alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl group.