Patent ID: 6664263
Filing Date: 2003-12-16
Classification: A61K,A61P,C07D

Abstract:
A compound of structure 1: whereinA is (CH2)m or (CHR)m; B is NRâ€², NRâ€²(CH2)nNRâ€³, hexahydropyrimidine-1,3-diyl, piperazine-1,4diyl, 4-aminopiperidine-1,4N-diyl, or 1,4-diazacycloheptane-1,4-diyl; D is (CH2)p or (CHR)p; Y1, Y2, Y3 and Y4 are independently R, COR, CO2R, CONRRâ€², SR, SOR, SO2R, SO2CF3, SO2NRRâ€², OR, OCF3, OCOR, OCONRRâ€², NO2, NRRâ€², CN, Ph, CF3, NRCORâ€², NRCONRâ€²Râ€³, NRC(NRâ€²)NRâ€³Râ€²â€³, NRCOCF3, NRSO2Râ€², NRSO2CF3, or halogen; R is H, CF3, lower alkyl, amino-lower alkyl, or hydroxy-lower alkyl; Râ€² and Râ€³ are independently R, C(O)R, or SO2R; and m, n, and p are independently 2-6.