Patent ID: 8551773
Filing Date: 2013-10-08
Classification: A61K,C07K,C12N

Abstract:
1. A viral particle comprising a recombinant lentiviral vector further comprising: (a) an expression cassette comprising a transgene positioned under the control of a promoter, other than a CMV promoter, that is active to promote detectable transcription of the transgene at a signal-to-noise ratio of between about 10 and about 200 in both a human hematopoietic progenitor cell and a differentiated hematopoietic cell; and (b) an LTR region that has reduced promoter activity relative to wild-type LTR, wherein the LTR region has been rendered substantially transcriptionally inactive by virtue of deletions in the U3 region of the 3′ LTR.