Patent ID: 6060463
Filing Date: 2000-05-09
Classification: A61K,A61P,Y10S

Abstract:
A method for reducing intraocular pressure, comprising administering to the eye an effective amount of a compound of formula I: ##STR8## or a pharmaceutically acceptable salt or ester thereof, wherein: R.sup.1 and R.sup.2 are (i) or (ii) as follows:(i) R.sup.1 is CH.sub.2 CH(OH)(CH.sub.2).sub.n, CH.sub.2 CH(CH.sub.2).sub.n (OH), CH.sub.2 OCH(R.sup.7),CH.sub.2 OCH(R.sup.7)(CH.sub.2).sub.p, CH.sub.2 OCH(R.sup.7)(CH.sub.2).sub.p O or O(CH.sub.2).sub.p CH(R.sup.7)O;R.sup.2 is OH or O(CH.sub.2).sub.r H;R.sup.7 is OH or (CH.sub.2).sub.r OH;n is 0-6;r is 1-6;p is 0-3; andm is 0 to 3(ii) R.sup.1, R.sup.2, n, m, r and p are defined as in (i), and R.sup.1 and R.sup.2 are linked to form a cyclic ester group;B is a pyrimidine or purine of formula (II): ##STR9## and is selected from the group consisting of pyrimidin-1-yl, pyrimidinyl-3-yl, purin-3-yl, purin-7-yl and purin9-yl; andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently selected from NH.sub.2, alkylamino, aminoalkyl, hydroxyalkyl, hydrazino, H, OH, SH, alkylthio, alkyl, alkoxy, alkoxyalkyl, halide, hydroxylamino and CH.sub.3 q(hal)q in which q is 1-3 and hal is a halide; andthe amount is effective for lowering intraocular pressure.