Patent ID: 6706752
Filing Date: 2004-03-16
Classification: C07D

Abstract:
An indole compound represented by the formula (I), or a pharmaceutically acceptable salt, solvate, or prodrug thereof; wherein;R1 is selected from groups (a), (b), and (c) wherein; (a) is C7-C20 alkyl, C7-C20 haloalkyl, C7-C20 alkenyl, C7-C20 alkynyl or carbocyclic radical, or (b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or (c) is the group â€”(L1)â€”R11; where, â€”(L1)â€” is a divalent linking group of 1 to 8 atoms and where R11 is a group selected from (a) or (b); R2 is hydrogen, or a group containing 1 to 4 non-hydrogen atoms plus any required hydrogen atoms; R3 is â€”(L3)â€”Z, where â€”(L3)â€” is a divalent linker group selected from a bond or a divalent group selected from: and Z is selected from a group represented by the formulae, wherein, X is oxygen and Ra is selected from hydrogen, C1-C8 alkyl, aryl, C1-C8 alkaryl, C1-C8 alkoxy, aralkyl and â€”CN;R4 is the group, â€”(Lc)-(acylamino acid group); wherein â€”(Lc)â€”, is an acylamino acid linker having an acylamino acid linker length of 1 to 8; R5 is selected from hydrogen or a non-interfering substituent; R6 and R7 are selected from hydrogen or a non-interfering substituent.