Patent ID: 9175334
Filing Date: 2015-11-03
Classification: C12Q

Abstract:
1. An in vitro method for determining if a cell co-receptor is used by a virus using a cell receptor and at least one cell co-receptor for entering a cell, in a patient infected with the virus, comprising: i) putting a sample of the patient which contains the virus in contact with a test cell expressing a cell receptor of the virus and at least one cell co-receptor of the virus, wherein the use of said cell co-receptor by the virus specifically modulates the expression of at least one miRNA; ii) determining the expression level of said at least one miRNA and/or of at least one target mRNA of said at least one miRNA in the test cell; iii) comparing the expression level with a predetermined value, said predetermined value being: iv) inferring therefrom whether the virus uses or not said at least one cell co-receptor expressed by said test cell,