Patent ID: 6143279
Filing Date: 2000-11-07
Classification: A61K,A61P,C07H,Y10S

Abstract:
A pharmaceutical composition, comprising, together in a pharmaceutically acceptable carrier, a compound of Formula I: ##STR4## wherein: X.sub.1, and X.sub.2 are each independently either O.sup.- or S.sup.- ;X.sub.3 and X.sub.4 are each independently either --H or --OH, with the proviso that X.sub.3 and X.sub.4 are not simultaneously --H;R.sub.1 is selected from the group consisting of O, imido, methylene and dihalomethylene;R.sub.2 is selected from the group consisting of H, halo, alkyl, substituted alkyl, nitro and azido;R.sub.3 is selected from the group consisting of H, alkyl, acyl, aryl, and arylalkyl; andR.sub.4 is selected from the group consisting of --OR', --SR', --NR', and --NR'R"", wherein R' and R"" are independently selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, alkoxyl, and aryloxyl, and with the proviso that R' is absent when R.sub.4 is double bonded from an oxygen or sulfur atom to the carbon at the 4-position of the pyrimidine ring;or a pharmaceutically acceptable salt thereof, in an amount effective to hydrate lung mucus secretions, with the proviso that said compound of Formula I is not uridine 5'-diphosphate.