Patent ID: 7282488
Filing Date: 2007-10-16
Classification: A01K,A61K,A61L,A61P,C12N,C12Y

Abstract:
1. A method for treating a mammal to resist early vein graft failure comprising, a) introducing into endothelial cells of an autologous vein graft from the mammal an effective amount of at least one nucleic acid encoding one of the following agents: thrombomodulin (TM), NF-κB inhibitor, or a functional fragment of the TM; provided that when the agent is thrombomodulin, the nucleic acid further encodes the NF-κB inhibitor, wherein the introducing is performed ex vivo or by direct injection into the graft, and b) transplanting the vein graft into the mammal when the introducino is performed ex vivo.