Patent ID: 6919332
Filing Date: 2005-07-19
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein R 1 is selected from the group consisting of hydrogen, (R 2 ) 2n+1 —(C) n — and (C 3 -C 7 )cycloalkyl; wherein said (C 3 -C 7 )cycloalkyl may be optionally substituted on any ring carbon atom able to support an additional substituent by one to two substituents independently selected from the group consisting of halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkenyl, (C 1 -C 4 )alkynyl, R 3 —, R 3 —O—, perfluoro(C 1 -C 4 )alkoxy, R 3 —(C 1 -C 4 )alkyl-O—, R 3 —(C═O)—O—, (R 3 ) 2 N—(C═O)—O—, —NO 2 , (R 3 ) 2 N—, R 3 —(C═O)—(NR 4 )—, R 3 —(SO 2 )—(NR 4 )—, R 3 O—(C═O)—(NR 4 )—, (R 3 ) 2 —N—(C═O)—(NR 4 )—, R 3 —S—, R 3 —(S═O)—, R 3 —(SO 2 )—, (R 3 ) 2 N—(SO 2 )—, —CN, R 3 —(C═O)—, R 3 —O—(C═O)— and (R 3 ) 2 N—(C═O)—; n is an integer from one to five; each R wherein not more than three of said R wherein a carbon atom of any two R each R wherein each R wherein each of said R wherein each of said R R wherein said R X is selected from the group consisting of —O—, >C═O, —S—, >SO R A is (C wherein said A (C Y is selected from the group consisting of a bond, —O—, —S—, >C═O, >SO R B is a (C wherein one ring nitrogen atom of B is bonded to one carbon atom of G; wherein said B may be optionally substituted on any of the ring carbon atoms capable of supporting an additional substituent by one or two substituents per ring independently selected from F, Cl, Br, CN, OH, (C G is (C p is an integer from zero to four; wherein said G (C R wherein each of said R wherein each of said R wherein each of said R each of R or R with the proviso that the group —B—G is not methylazetidinyl or methylpiperidinyl; or a pharmaceutically acceptable salt thereof.