Patent ID: 6743776
Filing Date: 2004-06-01
Classification: A61K,A61P,C07K

Abstract:
A polypeptide compound of the following general formula wherein R1 is one member selected from the group consisting of benzoyl substituted with piperazinyl substituted with piperidyl substituted with cyclo(lower)alkyl, benzoyl substituted with piperazinyl substituted with piperidyl having higher alkyl, benzoyl substituted with piperazinyl substituted with cyclo(lower)alkyl having lower alkyl, benzoyl substituted with piperidyl having phenyl having cyclo(lower)alkyloxy benzoyl substituted with piperidyl having phenyl having morpholinyl, benzoyl substituted with piperidyl having phenyl having phenyl(lower)alkoxy, benzoyl substituted with piperidyl having piperidyl having higher alkyl, benzoyl substituted with piperidyl having phenyl(lower)alkyl having lower alkoxy, benzoyl substituted with piperidyl having cyclo(lower)alkyl, benzoyl substituted with piperidyl having cyclo(lower)alkyl having cyclo(lower)alkyl, benzoyl substituted with piperidyl having cyclo(lower)alkyl having lower alkyl, benzoyl substituted with piperidyl having hydroxy, benzoyl substituted with piperidyl having hydroxy and phenyl having lower alkoxy, beuzoyl substituted with piperidyl having phenyl having lower alkoxy, benzoyl substituted with thiadiazolyl having phenyl having methoxy, benzoyl substituted with 1,2,3,6-tetrahydropyridyl, benzoyl substituted with 1,2,3,6-tetrahydropyridyl having phenyl having lower alkoxy, benzoyl substituted with thienyl, benzoyl substituted with thienyl having phenyl having lower alkoxy, benzoyl substituted with furyl, benzoyl substituted with furyl having phenyl having lower alkoxy, benzoyl substituted with piperazinyl(lower)alkyl, benzoyl substituted with phenyl(lower)alkynyl, benzoyl substituted with phenyl(lower)alkynyl having phenyl having lower alkoxy, lower alkanoyl substituted with thiazolyl, lower alkanoyl substituted with thiazolyl having phenyl having phenyl substituted with lower alkoxy, benzoyl substituted with imidazothiazolyl, benzoyl substituted with imidazotbiazolyl having phenyl having lower alkoxy, benzoyl substituted with imidazothiazolyl having phenyl having phenyl substituted with lower alkoxy, benzoyl substituted with imidazothiazolyl having phenyl having phenyl, benzoyl substituted with isoxazolyl having halogen, benzoyl substituted with isoxazolyl having halogen having phenyl having lower alkyl, and 4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoyl; and R2 is hydroxy, hydroxysulfonyloxy, or lower alkoxy, with the proviso that R2 is not hydroxysulfonyloxy when R1 is 4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoyl, and a salt thereof.