Patent ID: 8697058
Filing Date: 2014-04-15
Classification: A61L,A61P

Abstract:
1. A method of forming a cytocompatible alginate gel, comprising: providing an alginate; subjecting the alginate to a treatment that lowers the molecular weight of the alginate, wherein the treatment comprises UV irradiation, gamma irradiation, e-beaming, oxidation, or a combination thereof; dispersing substantially homogeneously within the alginate a plurality of cells and a plurality of vesicles to form a substantially homogenous alginate-cell-vesicle mixture; and adding to the alginate a divalent metal cation to form an alginate gel; wherein the divalent metal cation is at a relatively high concentration such that the divalent metal cation causes the plurality of vesicles to form pores within the alginate gel that are conducive to cell migration and proliferation.