Patent ID: 7265103
Filing Date: 2007-09-04
Classification: A61P,C07D

Abstract:
1. A compound according to the general Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof, wherein: X is CH R R with the proviso that at least one of R a and b are asymmetric centers; (CH Pir is a radical according to any one of Formula (IIa), (IIb) or (IIc) R wherein: d is a single bond while Z is either a bivalent radical selected from the group of —CH A is a 5- or 6-membered aromatic homocyclic or heterocyclic ring, selected from the group of phenyl, pyranyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, thienyl, isothiazolyl, pyrrolyl, imidazolyl, pyrazolyl, furanyl, oxadiazolyl and isoxazolyl; p is an integer ranging from 0 to 6; R R each R two vicinal radicals R may be taken together to form a bivalent radical —R R alkyl represents a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, optionally substituted with one or more methyl, halo, cyano, oxo, hydroxy, alkyloxy or amino radicals; alkenyl represents a straight or branched unsatured hydrocarbon radical having one or more double bonds, optionally substituted with one or more methyl, halo, cyano, oxo, hydroxy, alkyloxy or amino radicals; Ar represents phenyl or naphthyl, optionally substituted with one or more radicals selected from the group of alkyl, halo, cyano, hydroxy, alkyloxy and amino; and Het is a monocyclic heterocyclic radical selected from the group of azetidinyl, pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, piperazinyl, tetrahydrofuranyl, pyridinyl, and benzylpiperazinyl.