Patent ID: 6242432
Filing Date: 2001-06-05
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
Compounds, or their compositions, of the general formula:A--(X.sub.1 --NO.sub.2)t.sub.0or their salts, where:t.sub.0 is an integer equal to 1 or 2;A=RN.sub.0 where N.sub.0 =(COX.sub.u).sub.t -- or COON.sub.1 where t is an integer equal to zero or 1; u is an integer equal to 0 or 1;X=0, NH, NR.sub.1c where R.sub.1c is a linear or branched alkyl having from 1 to 10 carbon atoms; N.sub.1 is a linear or branched alkyl having from 1 to 10 carbon atoms or hydrogen;R is chose from the following groups:Group A) ##STR25##wherewhere R.sub.Ia and R.sub.IIa are equal or different one from the other and are H or a linear or whenever possible branched alkyl from 1 to 3 C atoms, preferably R.sub.IA =R.sub.IIa =H; n.sub.Ia is an integer from 1 to 6, preferably from 2 to 4;R.sub.I can be: ##STR26## ##STR27##where N.sub.2 has the same meaning as N.sub.0 ; at least one of the groups N.sub.0 or N.sub.2 having one free valence capable of binding to X.sub.1 (that is, t=1), ##STR28##R.sub.Ia, R.sub.IIa, n.sub.Ia are as defined in Ia;N.sub.3 is H, ##STR29##or a free valence to which X.sub.1 binds (that is, N.sub.3 is absent);R.sub.Ib is chosen from: ##STR30##N.sub.2 is as above defined, where at least one of the groups N.sub.3 or N.sub.2 has a free valence capable of binding to X.sub.1 (when it is N.sub.2, t=1); ##STR31##where N.sub.0 is as above defined where t=1, i.e., it has a free valence capable of binding to X.sub.1 ;R.sub.Ic is chosen from H, --COOH.sub.3, or ##STR32##where N.sub.2 is as defined, and at lest one of the groups N.sub.2 has a free valence (t=1) capable of binding to X.sub.1, with the proviso that when in group Ic) R.sub.IC is H or COCH, X cannot be NH;Group Bwhere t=1 and u=0; ##STR33##where R.sub.Ia, R.sub.IIa are as defined in Ia);R.sub.IIb has the meaning or R.sub.Ia ;R.sub.BA is chosen from: ##STR34## ##STR35##where in group B), N.sub.2 is as above defined and at least one of the N.sub.2 groups has a free valence capable of binding to X.sub.1, (that is, at least one N.sub.2 substituent has t=1);X.sub.1 is bivalent connecting bridge chosen from the following:YO where Y is linear or whenever possible branched C.sub.1 -C.sub.20 alkylene, preferably having from 2 to 5 carbon atoms, or an optionally substituted cycloalkylene having from 5 to 7 carbon atoms;Y.sub.1 chosen from ##STR36##where n.sub.3 is an integer from 0 to 3; ##STR37##where nf' is an integer from 1 to 6; ##STR38##where R.sub.1f =H, CH.sub.3 and nf is an integer from 1 to 6.