Patent ID: 7473416
Filing Date: 2009-01-06
Classification: A61M,A61P,Y10S

Abstract:
1. A method of treating asthma comprising, providing a surface active phospholipid (SAPL) composition as a dry powder, said composition comprising a diacyl phosphatidyl choline (DPC) selected from the group consisting of dioleyl phosphatidyl choline (DOPC), distearyl phosphatidyl choline (DSPC) and dipamitoyl phosphatidyl choline (DPPC), and a spreading agent for said DPC, said spreading agent being selected from the group consisting of phosphatidyl glycerols (PG), phosphatidyl ethanolamines (PE), phosphatidyl serines (PS), phosphatidyl inositols (PI) and cholesteryl palmitate (CP); and administering said SAPL composition to the lungs of an asthma patient as an inhalable dry powder; whereby binding of SAPL to the tissue surfaces of the lungs forms a coating of SAPL on said surfaces thereby preventing pollutants and other airborne triggers from reaching the receptors whose irritation would produce an acute asthma attack and reducing the number of said receptors exposed to noxious stimuli and reducing hyper-responsiveness of the broncho-constrictor reflex.