Patent ID: 9145364
Filing Date: 2015-09-29
Classification: C07D

Abstract:
1. A one pot, one step process for preparation of compound of Formula 2, wherein, R R R3 represents independently alkyl(C1-C5), vinyl; or R2 and R3 cyclize to form —CH2—(CH R4 represents independently hydrogen, alkyl, —(CH CH2═CH—CN; n is 1, 2 and 3; comprising the steps of: i. mixing a compound of formula (1a) wherein R R R3 represents independently alkyl(C1-C5), vinyl; with sodium azide in the ratio ranging between 1.2 to 1.5 eq. in the presence of 15 to 25mol % copper catalyst, 15 to 25 mol % sodium ascorbate and 15 to 25 mol % L-proline, 1.5-2.0% of base and solvent followed by stirring to obtain compound of formula 2.