Patent ID: 8999341
Filing Date: 2015-04-07
Classification: A61K,C07K,C12Q

Abstract:
1. A method of reducing cholesterol level or maintaining previously reduced cholesterol level in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a proprotein convertase subtilisin/kexin type 9 (PCSK9) that comprises a C-terminal domain comprising a mutation selected from the group consisting of: I474V; E670G; N425S; and Q619P in SEQ ID NO: 1; wherein the antibody or fragment comprises a human IGLC2*01 light chain constant region and wherein said human comprises: (i) a human IGLC2*01 nucleotide sequence or the human expresses antibodies comprising human light chain IGLC2*01 constant regions and (ii) a nucleotide sequence encoding said proprotein convertase subtilisin/kexin type 9 (PCSK9) that comprises a C-terminal domain comprising said selected mutation in SEQ ID NO: 1.