Patent ID: 8101365
Filing Date: 2012-01-24
Classification: A61K,A61P,C07K

Abstract:
1. An isolated anti-EphB4 monoclonal antibody comprising six hypervariable regions (HVRs), wherein each HVR comprises a sequence selected from the group consisting of SEQ ID NOs: 1-17, and wherein SEQ ID NO:9 or 10 correspond to an HVR-L1, SEQ ID NO:11 or 12 correspond to an HVR-L2, SEQ ID NO:13, 14, 15, 16, or 17 correspond to an HVR-L3, SEQ ID NO:1 or 2 correspond to an HVR-H1, SEQ ID NO:3, 4, 5, or 6 correspond to an HVR-H2, and SEQ ID NOs:7 or 8 correspond to an HVR-H3.