Patent ID: 6649655
Filing Date: 2003-11-18
Classification: A61K

Abstract:
A method of antagonizing FP receptors, comprising exposing such receptors to a compound of formula I: wherein:R1=CO2R, CONR4R5, CH2OR6, or CH2NR7R8; where: R=H or cationic salt moiety, or CO2R=pharmaceutically acceptable ester moiety; R4, R5=same or different=H or alkyl; R6=H, acyl or alkyl; R7, R8=same or different=H, acyl, or alkyl; with the proviso that if one of R7, R8=acyl, then the other=H or alkyl; n=0 or 2; R2, R3=same or different=H, alkyl, or acyl; ----=single or non-cumulated double bond, with the provisos that if a double bond is present between carbons 4 and 5, it is of the cis configuration; and that if a double bond is present between carbons 13 and 14, it is of the trans configuration; X=(CH2)m or (CH2)mO, where m=1-6; and Y=phenyl, optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; or X-Y=(CH2)pY1; where p=0-6; and wherein: W=CH2, O, S(O)q, NR10, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)q, CH&boxH;N, or CH2NR9; where q=0-2, and R10 H, alkyl, or acyl; Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and ----=single or double bond.