Patent ID: 6365572
Filing Date: 2002-04-02
Classification: A61K,A61P,C07K

Abstract:
A compound of formula I in any stereoisomeric form, or a physiologically tolerable salt thereof, or a mixture thereof, whereinR1 is â€ƒwherein R4 is â€”A, â€”NH2, â€”NHR, â€”NR2, and R5 is â€”(CH2)lCOOA, â€”(CH2)lCONH2, â€”(CH2)lNH2, â€”(CH2)lâ€”SO3H, X is â€ƒwherein Y is O, S, â€”N(A)â€”COâ€” or â€”(CH2)râ€”, D is (CH2)r, O, S, NH, NR, (CH2)râ€”O, (CH2)râ€”S, (CH2)râ€”NH or (CH2)rNR and R2 is â€”Eâ€”OH, â€”Eâ€”COOH or â€”Eâ€”CONH2, wherein E is a linear or branched C1-C10-alkyl chain, which is unsubstituted or substituted by â€”A, â€”(CH2)mâ€”OH, â€”(CH2)mâ€”COOH, â€”(CH2)mâ€”C(O)NA2 or by a C5-C10-cycloalkyl group, or E is C5-C10-cycloalkyl, which is unsubstituted or substituted by â€”A, â€”(CH2)mâ€”OH, â€”(CH2)mâ€”COOH, â€”(CH2)mâ€”C(O)NA2 or by a C5-C10-cycloalkyl group, R3 is wherein R6 is â€”H, â€”COOH, â€”CONH2, â€”CONHR, â€”CONR2, â€”CH2OH or and wherein R7 is a linear or branched C1-C10-alkyl group, which is unsubstituted or substituted by â€”A, â€”(CH2)mâ€”OH, â€”(CH2)mâ€”COOH, â€”(CH2)mâ€”C(O)NA2 or by a C5-C10-cycloalkyl group, or R7 is a C5-C10-cycloalkyl group, which is unsubstituted or substituted by â€”A, â€”(CH2)mâ€”OH, â€”(CH2)mâ€”COOH, â€”(CH2)mâ€”C(O)NA2 or by a C5-C10-cycloalkyl group, and R is branched or unbranched C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C5-C10-cycloalkyl, Het or Ar which are unsubstituted or substituted by one or more halogen, C1-C6-alkyloxy, branched or unbranched C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C5-C10-cycloalkyl groups or by â€”C1-C6-alkyl-Het, â€”C1-C6-alkyl-Ar, â€”Oâ€”C1-C6-alkyl-Het, â€”Oâ€”C1-C6-alkyl-Ar, Het or by Ar, wherein Het is a monocyclic or bicyclic, 5- to 10-membered aromatic or non-aromatic ring containing 1 or 2 equal or different hetero-atoms as members of said ring, the heteroatoms being selected from the group consisting of nitrogen, oxygen and sulfur, â€ƒwhich ring is unsubstituted or substituted by one or more hydroxy or carboxy groups, and wherein Ar is a monocyclic or bicyclic 5- to 10-membered aromatic ring which is unsubstituted or substituted by one or more hydroxy or carboxy groups, Z is (CH2)m, O, S, NH, NR, Nâ€”C(O)â€”R or NSO2R, A is H or C1-C4-alkyl l, m and r are each independently integers from 0 to 3, n and k are each independently integers from 1 to 2, p is an integer from 0 to 1 and q is an integer from 1 to 3.