Patent ID: 7235259
Filing Date: 2007-06-26
Classification: A61K,A61P

Abstract:
1. A method for forming a pharmaceutical composition, comprising: (a) forming a solution comprising a cholesteryl ester transfer protein inhibitor, a concentration-enhancing polymer, and a solvent; (b) rapidly removing said solvent from said solution to form a solid amorphous dispersion comprising said cholesteryl ester transfer protein inhibitor and said concentration-enhancing polymer; and (c) said concentration-enhancing polymer being present in said solution in a sufficient amount so that said solid amorphous dispersion provides a maximum concentration of said cholesteryl ester transfer protein inhibitor in a use environment that is at least 10-fold the equilibrium concentration provided by a control composition consisting essentially of an equivalent amount of said cholesteryl ester transfer protein inhibitor but with no concentration-enhancing polymer wherein said cholesteryl ester transfer protein inhibitor has the Formula IV and pharmaceutically acceptable forms thereof; wherein R wherein W X R R R