Patent ID: 7504226
Filing Date: 2009-03-17
Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
1. A method of screening for a test compound which may be useful in the treatment of an atherosclerotic disorder comprising: (a) contacting a first portion of a sample obtained from an individual having an atherosclerotic disorder with (b) contacting a second portion of the sample obtained from the individual having an atherosclerotic disorder with wherein said sample is an atherosclerotic lesion or serum sample comprising IgG molecules which bind to said wherein said test compound is a potential inhibitor of antibody-mediated lipid oxidation; and (c) measuring lipid oxidation in sample (a) and lipid oxidation in sample (b) and comparing the lipid oxidation in sample (a) and the lipid oxidation in sample (b), wherein when the lipid oxidation in sample (a) is less than the lipid oxidation in sample (b), then the test compound may be useful in the treatment of an atherosclerotic disorder.