Patent ID: 7407670
Filing Date: 2008-08-05
Classification: A61K,A61P

Abstract:
1. A solid dispersion comprising a poorly soluble bioactive compound, which has a solubility of less than 1 gram per liter in an aqueous environment, dispersed in a polymer matrix that comprises a first polymer comprising a copolymer of vinylpyrrolidone and vinylacetate, and a second polymer that has a dissolution profile associated with the creation of a micro-environment enhancing the dissolution of the bioactive compound in said aqueous environment, wherein said second polymer comprises a cationic polymer based on dimethylaminoethyl methacrylate and neutral methacrylic ester, and wherein said first polymer and said second polymer are present in a ratio of 70-80 percent by weight of said first polymer to 20-30 percent by weight of said second polymer.