Patent ID: 6096758
Filing Date: 2000-08-01
Classification: A61P,C07D

Abstract:
A compound of the formula I in whichR0 is 1-4C-alkyl, hydroxymethyl or trifluoromethyl,R1 is 1-4C-alkyl,R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, halogen or trifluoromethyl,R3 is SO.sub.2 --R6,R4 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, halogen or trifluoromethyl,R5 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy or halogen,A is O (oxygen) or NH,R6 is 1-4C-alkyl, aryl, aryl substituted by R16, R17 and R18, aryl-1-4C-alkyl, aryl-1-4C-alkyl substituted in the aryl moiety by R16, R17 and R18, 1-4C-alkyl completely or partly substituted by fluorine,1-4C-alkyl substituted by --S(O).sub.n --R19 or the radical --C.sub.q H.sub.2q-2 -aryl, or a cyclic substituent selected from the group consisting of thiolane, thiolane oxide or thiolane dioxide, which is unsubstituted or substituted by hydroxyl,R7 is aryl, aryl-1-4C-alkyl, aryl substituted by R16, R17 and R18, or aryl-1-4C-alkyl substituted in the aryl radical by R16, R17 and R18,R8 is 2-4C-alkyl substituted by R11, 1-4C-alkyl substituted by R12, --N.dbd.C(R13)R14, 2-4C-alkyl substituted by R15, aryl, the radical --C.sub.q H.sub.2q-1 or aryl substituted by R16, R17 and R18,R9 is hydrogen or 1-4C-alkyl,R10 is 2-4C-alkyl substituted by R11, 1-4C-alkyl substituted by R12, or 1-4C-alkyl,R11 is 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, hydroxyl, hydroxy-2-4C-alkoxy or 1-4C-alkoxy-1-4C-alkoxy,R12 is 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, carboxyl, mono-1-4C-alkylaminocarbonyl, di-1-4C-alkylaminocarbonyl, thienyl, pyridyl, aryl or aryl substituted by R16, R17 and R18,R13 is 1-4C-alkyl, phenyl or phenyl-1-4C-alkyl andR14 is 1-4C-alkyl, phenyl or phenyl-1-4C-alkyl, or in whichR13 and R14 together are a 4-6C-alkylene group,R15 is phthalimidyl or --S(O).sub.n --R19, whereAryl is phenyl or naphthyl andR16 is hydrogen, halogen, nitro, 1-4C-alkyl, 1-4C-alkoxy, trifluoromethyl, hydroxyl, carboxyl, 1-4C-alkoxycarbonyl, cyano, 1-4C-alkoxy completely or partly substituted by fluorine, phenyl, benzoyl, mono- and di-1-4C-alkylamino, amino, 1-4C-alkylcarbonylamino or S(O).sub.n ----R19,R17 is hydrogen, halogen, 1-4C-alkoxy, nitro, carboxyl, 1-4C-alkyl or hydroxyl andR18 is hydrogen or halogen,R19 is 1-4C-alkyl,n is the numbers 0, 1 or 2,q is the numbers 2 or 3,and their salts, and the N-oxides of the pyridines or a salt thereof.