Patent ID: 6333447
Filing Date: 2001-12-25
Classification: A01K,A61K,C07K,C12N

Abstract:
A transgenic mouse from 8 to 16.8 months of age displaying manifestations of heart failure selected from the group consisting of (a) shortness of breath relative to a control mouse, (b) pitting edema relative to a control mouse, (c) an enlarged tender liver relative to a control mouse, (d) engorged neck veins relative to a control mouse, and (e) pulmonary rates relative to a control mouse, wherein the genome of said mouse comprises a murine .alpha.-myosin heavy chain gene promoter operably linked to a nucleotide sequence encoding G.sub.s.alpha. MRNA, and expresses G.sub.s.alpha. mRNA in its cardiac tissue at a level that is at least 3-fold higher than in cardiac tissue of a control mouse.