Patent ID: 6537789
Filing Date: 2003-03-25
Classification: C07K,C12N,C12R

Abstract:
An isolated acylase enzyme obtained from a strain of microorganism belonging to the genus Streptomyces, wherein said enzyme catalyzes deacylation of the acyl group R1 of a cyclic lipopeptide compound of the following general formula I: or a salt thereof,whereinR1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl; to produce a cyclic peptide compound of the following formula (II): or a salt thereof,wherein R2, R3, R4, R5, and R6 are as defined above.