Patent ID: 9095414
Filing Date: 2015-08-04
Classification: A61F,A61N

Abstract:
1. An apparatus configured to perform nonlinear optical photodynamic clinical therapy of a cornea of an eye comprising: a pulsed infrared laser configured to provide a multiphoton beam at a predetermined intensity and having a beam width; a scanner configured to selectively and controllably move the beam relative to the cornea in an x and y plane; a variable beam expander configured to selectively vary the beam width; and a focusing objective lens configured to: wherein the variable beam expander is configured to selectively adjust an effective numerical aperture of the focusing objective lens by varying the beam width incident on the focusing lens and hence the focal volume of the beam in the cornea, wherein the beam expander is configured to vary the effective numerical aperture between 0.16 and 0.08 and the focal volume between 150 and 2500 femtoliters respectively, and the apparatus is configured to achieve collagen cross-linking of the entire cornea in less than 10 minutes using a selected scanner speed and a focal volume between 150 and 2500 femtoliters.