Patent ID: 7947719
Filing Date: 2011-05-24
Classification: A61P,C07D

Abstract:
1. A compound comprising: a structure according to Formula II: wherein carbon atom C5 is substituted with R4, carbon atom C6 is substituted with R6, carbon atom C7 is substituted with R8, carbon atom C8 is substituted with R10, carbon atom C9 is substituted with R12, carbon atom C10 is substituted with R14, carbon atom C11 is substituted with R16, carbon atom C12 is substituted with X1, carbon atom C5′ is substituted with R18, carbon atom C6′ is substituted with R20, carbon atom C7′ is substituted with R22, carbon atom C8′ is substituted with R24, carbon atom C9′ is substituted with R26, carbon atom C10′ is substituted with R28, carbon atom C11′ is substituted with R30 and carbon atom C12′ is substituted with X2; wherein substituents R4, R6, R8, R10, R12, R14, R16, R18, R10, R22, R24, R26, R28 and R30 are each hydrogen; wherein X1 and X2 are, independently, selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, carbonyl, acetyl, alkoxyl, aryloxyl, arylalkyloxyl, mono-alkylamino, di-alkylamino, alkylcyano, disulfidylalkyl, and alkylsulfidyl substituents; wherein X1 and X2 are further substituted in their alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, carbonyl, acetyl, alkoxyl, aryloxyl, arylalkyloxyl, mono-alkylamino, di-alkylamino, alkylcyano, disulfidylalkyl, and/or alkylsulfidyl groups by 1, 2 or 3 substituents independently selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, arylsulfonyl, arylalkylsulfonyl, halogen, fluoro, chloro, bromo, iodo, —N wherein said alkyl groups have 1 to 12 carbon atoms; said cycloalkyl groups have 3 to 30 carbon atoms; said cycloalkyl contains 1 to 3 rings; said alkenyl group includes from 2 to 12 carbon atoms; said alkynyl group includes from 2 to 12 carbon atoms; said aryl group includes 3 to 14 carbon atoms; said heteroaryl group includes a 5-, 6- or 7-membered cyclic aromatic having from 1 to 5 first heteroatoms, each first heteroatom being independently selected from the group consisting of nitrogen, oxygen and sulfur; and said heterocyclyl includes 3 to 14 carbon atoms and from 1 to 5 second heteroatoms, at least 5 of said carbon atoms forming a non-aromatic ring, said second heteroatoms being independently selected from the group consisting of nitrogen, oxygen and sulfur.