Patent ID: 6960345
Filing Date: 2005-11-01
Classification: A61K,C12N

Abstract:
1. An oral vaccine comprising: a replication-defective or deficient vaccinia virus, or a modified vaccinia virus strain that is unable to generate infectious virus in human cells but is able to replicate in an animal host cell which is permissive for the virus, in a formulation comprising hydroxyethyl starch, mannitol, nutritional supplement grade fish oil, glycerol, and gelatin; wherein gel-sol virus carrier excipient components comprising a mixture of equal parts of microcrystalline cellulose and guar gum; water-dispersible microcrystalline cellulose containing sodium carboxymethylcellulose (NaCMC); and internally cross-linked, water-insoluble sodium carboxymethylcellulose (NaCMC) is added to the formulation to form a paste or gel for oral delivery.