Patent ID: 6548636
Filing Date: 2003-04-15
Classification: A61K,C07K

Abstract:
A compound comprising the structure:&thgr;&agr;YDINYYTSE&bgr;&lgr;wherein T represents a threonine, S represents a serine, E represents a glutamic acid, each Y represents a tyrosine, D represents an aspartic acid, I represents an isoleucine, and N represents an asparagine;wherein &agr; represents from 0 to 9 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the I at position 9 and extending therefrom in the amino terminal direction; wherein &bgr; represents from 0 to 13 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the P at position 19 and extending therefrom in the carboxyl terminal direction; wherein &thgr; represents an amino group or an acetylated amino group; wherein &lgr; represents a carboxyl group or an amidated carboxyl group; wherein all of &agr;, Y, D, I, N, Y, Y, T, S, E and &bgr; are joined together by peptide bonds; further provided that at least two of the tyrosines represented by Y in the YDINYYTSE portion of the structure of the compound are sulfated.