Patent ID: 6818652
Filing Date: 2004-11-16
Classification: A61P,C07D

Abstract:
A compound according to structural formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof wherein:n is an integer from 0 to 2; A is aryl or pyridinyl; B is NR6; R6 is hydrogen or alkyl; Y is â€”OR7, â€”SR7 or â€”NR8R9; R7 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl; R8 and R9 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl or together with the nitrogen atom to which they are attached form a heterocycloamino ring; Z is â€”C(R101)2Oâ€”, R102Câ€”CR102â€”, â€”C&boxH;Câ€”, â€”C(R103)2Sâ€”, â€”C(O)Oâ€” or â€”C(O)NR10â€”; each of R10, R101, R102 and R103 is independently hydrogen or alkyl; R1 and R2 are independently hydrogen or alkyl; R3 is hydrogen or alkyl; and R4 and R5 are independently hydrogen, (C1-C8) alkyl or arylalkyl.