Patent ID: 9217023
Filing Date: 2015-12-22
Classification: A61K,A61P,C07K

Abstract:
1. A peptide comprising the amino acid sequence: wherein X consists of a branched amino acid probe (BAP) consisting of three lysine residues, wherein the branch point of the BAP is formed by an amide bond between the ε-amino group of one lysine residue with the carboxyl group of another lysine residue, all other bonds being regular peptide bonds, including the bond to (aa 1 ) n , and wherein one or more alpha amino groups of X are optionally acetylated; (aa 1 ) n , is selected from the group consisting of Ser-Tyr-Ser-Met-Glu (SEQ ID NO: 17), Ser-Tyr-Ser-Nle-Glu (SEQ ID NO: 18), Ser-Ser-Ile-Ile-Ser (SEQ ID NO: 19), Tyr-Val-Met-Gly (SEQ ID NO:20) and Tyr-Val-Nle-Gly (SEQ ID NO:21); n is 1, 2, 3, 4 or Y is selected from the group consisting of His-Phe-Arg-Trp (SEQ ID NO: 16), His-(D-Phe)-Arg-Trp, His-Phe-(D-Arg)-Trp, His-Phe-Arg-(D-Trp), His-(D-Phe)-Arg-(D-Trp), His-Nal-Arg-Trp and His-(D-Nal)-Arg-Trp; (aa 2 ) m is Gly, Asp, or is absent; m is 0 or 1; and Z is selected from the group consisting of Lys-Pro-Val, Lys-Pro-(D-Val), Arg-Phe-Gly, Arg-(D-Phe)-Gly, Arg-Phe and Arg-(D-Phe), wherein the C-terminal carboxylic group is optionally an amide (—NH 2 ) or a pharmaceutically acceptable ester, or a pharmaceutically acceptable salt thereof.