Patent ID: 6337064
Filing Date: 2002-01-08
Classification: A61K,C07C,Y10S

Abstract:
A compound of formula (I) in the racemic or optically active form: wherein:R1, R2 are independently a hydrogen atom, or a straight or branched (C1-C20) alkyl chain, saturated or unsaturated, said chain optionally interrupted by one or more nitrogen or sulfur atoms, as well as by â€”COâ€”, â€”CONHâ€”, â€”NHCOâ€”, â€”SOâ€”, â€”SO2â€”, â€”SO2NHâ€” groups, or optionally substituted by one or more NH2, OH, halogen, COOH groups and the respective ester or amide derivatives, said chain in any case interrupted or substituted by one or more R3 cyclic residues, which are the same or different, non-fused or fused, provided that, when some of the R3 residues are fused together, the maximum number of rings forming the corresponding polycyclic unit is three, wherein R3 is a 5- or 6-membered cyclic unit, carbocyclic or heterocyclic, saturated, unsaturated or aromatic, said cyclic units unsubstituted or substituted with one or more R4 groups, which are the same or different, wherein R4 is OH, halogen, NHR5, N(R5)2, â€”Oâ€”R5, â€”Sâ€”R5, or â€”COâ€”R5, wherein the R5 groups, which are the same or different, are straight or branched (C1-C5) alkyl, unsubstituted or substituted with one or more hydroxy and/or alkoxy and/or carboxy groups, or R4 is a COOH group, or an ester or amido derivative thereof, or a â€”SO3H group or an amido derivative thereof, or R4 is a â€”Oâ€”R6 group, wherein R6 is a 5- or 6-membered cyclic unit, carbocyclic or heterocyclic, saturated, unsaturated or aromatic, said cyclic unit optionally substituted by one or more OH, halogen, â€”NHR5, â€”N(R5)2, â€”Oâ€”R5, â€”Sâ€”R5, â€”COâ€”R5 groups, or by one or more â€”COOH groups, or the ester or amido derivatives thereof, or â€”SO3H or amido derivatives thereof, provided that R1 and R2 are not at the same time hydrogen; or a chelate thereof with a manganese ion in an oxidation state +2 (Mn(II)) or a salt thereof with a physiologically compatible organic base selected from a primary, secondary or tertiary amine or a basic amino acid, or with an inorganic base whose cation is sodium, potassium, magnesium, calcium, or mixtures thereof.