Patent ID: 6448260
Filing Date: 2002-09-10
Classification: C07C,C07D,C07F

Abstract:
A pharmaceutical composition comprising a compound of Formula (I): wherein:R1 is â€”X(CH2)nAr, dihydrobenzofuranyl, benzodioxanyl, cyclohexyl or C1-4 alkyl, wherein Ar is a moiety of formula (a) or (b); R2 is a moiety of formula (a) or (b); P1 is â€”X(CH2)nR8; P2 is hydrogen or C1-4 alkyl; R6 is independently hydrogen or C1-4 alkyl; R7 is indenpendently hydrogen, C1-10 alkyl, C2-10 alkenyl or C2-8 alkynyl, all of which may be unsubtituted or substituted by one or more OH, N(R6)2, CO2 R12, Br, Cl, F, I, or XC1-5 alkyl; or R7 is (CH2)nAr; R8 is hydrogen, R11, CO2 R7, CO2 C(R11)2 O(CO)XR7, PO3 (R7)2, SO2 NR7 R11, NR7 SO2 R11, CONR7 SO2 R11, SO3 R7, SO2 R7, P(O)(OR7)R7, CN, - CO2(CH2)mC(O)N(R6)2, C(R11)2N(R7)2, C(O)N(R6)2, tetrazole or OR6; R9 is a bond, C1-10 alkylene, C2-10 alkenylene, C1-10 alkylidene, C2-10 alkynylene, all of which may be linear or branched, or R9 is phenylene, all of which may be unsubstituted or substituted by one or more OH, N(R6)2, COOH or halogen; R10 is hydrogen; R11 is hydrogen, Ar, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, all of which may be unsubstituted or substituted by one or more OH, CH2 OH, N(R6)2 Br, Cl, I, or F; R12 is hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-7 alkynyl; R13 is divalent Ar, C1-10 alkylene, C1-10 alkylidene, C2-10 alkenylene, C2-10 alkynylene, all of which may be unsubstituted or substituted by one or two OH, CH2 OH, N(R6)2 Br, Cl, I, or F; X is (CH2)n or O; Y is CH3 or X(CH2)n Ar; Ar is: naphthyl, indolyl, pyridyl, thienyl, oxazolidinyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, pyrrolyl, or pyrimidyol;all of which may be unsubstituted or substituted by one or two OH, C1-5 alkoxy, I, Br,F,Cl, â€”OC1-4alkylphenyl, R13CO2R7, C1-4alkyl, â€”N(R6)2, â€”NH(CO)CH3, â€”X(CH2)nR8, â€”X â€”R9â€”Y, pyridyl, phenyl or S(O)qC1-5alkyl, provided that when R13, R8 or Y are Ar, the Ar is not substituted by another Ar which is further substituted by an yet another Ar; A is C&boxH;O, or (C(R6)2)m; B is â€”CH2â€” or â€”Oâ€”; Z1, Z2 and Z3 are indenpendently hydrogen,OH, C1-8alkoxy, S(O)qC1-8alkyl, N(R6)2, Br, F, I, Cl, NHCOR6, â€”X â€”R9â€”Y, â€”X(CH2)nR8; or Z1 and Z2 together may be â€”Oâ€”Aâ€”Oâ€”on contiguous carbons; q is zero, one or two; n is an integer from 0 to six; m is 1, 2or 3; or a pharmaceutically acceptable salt thereof; provided that when Z1, Z2, or Z3 is X(CH2)nR8 and n is not 0, X is oxygen or when R8 is OR6 or CO2H; provided P1 is not CO2H, C(R6)2COOH or tetrazole when P2 is hydrogen and further provided R8 is not CN when Ar is a moiety of formula (a) or (b) wherein A is CH2 and B is O; and a pharmaceutically acceptable carrier.