Patent ID: 7683078
Filing Date: 2010-03-23
Classification: A61K,A61P,C07D

Abstract:
1. A sulfonamide according to formula I a geometrical isomer thereof, an optically active form thereof, an enantiomer thereof, a diastereomer thereof, a mixture thereof, or a salt thereof wherein: Ar X is O or S; Ar R R or R R or R R R m is an integer from 1 to 5; n is an integer from 0 to 2; and p is an integer from 1 to 10; wherein the compound according to formula I is selected from the group consisting of 4-Chloro-N-{5-[1-(4-trifluoromethyl-benzyl)-piperidin-3-ylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-{5-[2,2-dimethyl-3-(4-trifluoromethyl-benzylamino)-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-(5-{3-[methyl-(4-trifluoromethyl-benzyl)-amino]-propylsulfamoyl}-thiophen-2-ylmethyl)-benzamide; 4-Chloro-N-{5-[3-(hexyl-methyl-amino)-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-{5-[2-(4-trifluoromethyl-benzylamino)-cyclohexylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-[5-(2 hexylamino-ethylsulfamoyl)-thiophen-2-ylmethyl]-benzamide; 4-Chloro-N-{5-[1-(4-trifluoromethyl-benzyl)-piperidin-4-ylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-[5-(3-hexylamino-2,2-dimethyl-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-{5-[3-(4-trifluoromethyl-benzylamino)-benzylsulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-{5-[3-(4-trifluoromethyl-benzylamino)-propylsulfamoyl]thiophen-2-ylmethyl)benzamide; 4-Chloro-N (5-{[1-(4-trifluoromethyl-benzyl)-piperidin 3-ylmethyl]-sulfamoyl}-thiophen-2-ylmethyl)-benzamide; 4-Chloro-N (5-{methyl-[3-(4-trifluoromethyl-benzylamino)-propyl]-sulfamoyl}-thiophen-2-ylmethyl)-benzamide; 4-Chloro-N-{5-[(3-hexylamino-propyl)-methyl sulfamoyl]-thiophen-2-ylmethyl}-benzamide; 4-Chloro-N-(5-{[1-(4-trifluoromethyl-benzyl)-pyrrolidin-2-ylmethyl]-sulfamoyl}-thiophen-2-ylmethyl)-benzamide; and 4-Chloro-N-{5-[2,2-dimethyl-3-(3-trifluoromethanesulfonyl-phenylamino]-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide.