Patent ID: 8791083
Filing Date: 2014-07-29
Classification: A61P,C07H,C12N

Abstract:
1. A method of reducing cell surface expression of CD86 in an MH-S cell comprising contacting the cell with a compound having at least 5 separate regions, wherein each of the regions is a continuous sequence from 1 to 5 nucleosides each comprising a 3′-endo sugar conformational geometry or a continuous sequence of 1 to 4 2′-deoxyribonucleosides, and wherein each of the regions comprising from 1 to 4 2′-deoxyribonucleosides is internally located between two of the regions comprising 1 to 5 nucleosides each comprising a 3′-endo sugar conformational geometry or at one of the 3′ or 5′-termini, wherein the compound has a nucleobase sequence at least 90% complementary to SEQ ID NO. 10, and thereby reducing cell surface expression of CD86 in said MH-S cell; wherein said nucleosides comprising 3′-endo sugar conformational geometry comprise, independently, a 2′-substituent group selected from 2′-F, 2′-OCH 3 and 2′-MOE.