Patent ID: 6548251
Filing Date: 2003-04-15
Classification: C12Q

Abstract:
A method of inhibiting at least one molecular process involving the interaction between nucleic acids in a sample capable of undergoing said at least one molecular process, comprising:administering to said sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): Aâ€”Xnâ€ƒâ€ƒ(I) wherein n is at least 1, A is a nucleotide or nucleoside having a ribose or deoxyribose sugar, wherein each X is attached to a carbon atom of the ribose or deoxyribose sugar, or A is not a nucleotide or nucleoside, and each X is independently selected from the group consisting of â€”NRCOCONu, â€”NHCOCR2CR2CONu, â€”NHCOCR&boxH;CRCONu, and â€”NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile.