Patent ID: 6653484
Filing Date: 2003-11-25
Classification: A61K,A61Q,C07C,C07D,C08K,Y10S

Abstract:
A compound of one of the formulae I or IIA1â€”L1â€ƒâ€ƒ(I) A1â€”L2â€”A1â€ƒâ€ƒ(II) in whichA1 independently at each occurrence is a radical of the formula IVA, IVB or IVC B1 is the bridge member â€”Oâ€” or â€”NHâ€”, L1 is a polyoxyalkylene radical of the formula VI â€”CH2â€”CH(OH)â€”CH2â€”Oâ€”(CH2â€”(CH2)uâ€”Oâ€”)mâ€”D1â€ƒâ€ƒ(VI) in which D1 is hydrogen, â€”CH2â€”CH(OH)â€”CH2â€”OH or R16; or is a polyoxyalkylene radical of the formula VII â€”COâ€”(CH2)uâ€”Oâ€”(CH2â€”(CH2)uâ€”Oâ€”)mâ€”D2â€ƒâ€ƒ(VII) in which D2 is â€”(CH2)uâ€”COâ€”R13 or R16;or is a polyoxyalkylene radical of the formula VIII â€”Yâ€”Oâ€”COâ€”(CH2)uâ€”Oâ€”(CH2(CH2)uâ€”Oâ€”)mâ€”D3â€ƒâ€ƒ(VIII) in which D3 is â€”(CH2)uâ€”COâ€”R13 or R16;or is a polyoxyalkylene radical of the formula IX â€”(CH2)kâ€”CH(R12)â€”COâ€”B1â€”(CnH2nâ€”Oâ€”)mâ€”CnH2nâ€”B1â€”D4â€ƒâ€ƒ(IX) in which D4 is hydrogen or R16;or is a polyoxyalkylene radical of the formula X â€”COâ€”CH2â€”CH2â€”NHâ€”(CnH2nâ€”Oâ€”)mâ€”CnH2nâ€”D5â€ƒâ€ƒ(X) in which D5 is â€”NH2, â€”NHâ€”(CH2)2â€”COOâ€”R14 or â€”Oâ€”R16;or is a polyoxyalkylene radical of the formula XI â€”Yâ€”Oâ€”COâ€”CH2â€”CH2â€”NHâ€”(CnH2nâ€”Oâ€”)mâ€”CnH2nâ€”D5â€ƒâ€ƒ(XI) in which D5 is as defined under formula (X);or is a polyoxyalkylene radical of the formula XII â€”(CnH2nâ€”Oâ€”)mâ€”CnH2nâ€”D6â€ƒâ€ƒ(XII) in which D6 is â€”NHâ€”COâ€”R15; or is a polyoxyalkylene radical of the formula XIII â€ƒin which D7 is â€”OR16, â€”NHCOR15 or â€”OCH2CH2OR16; L2 is a polyoxyalkylene bridge member of the formula XIVâ€”CH2â€”CH(OH)â€”CH2â€”Oâ€”(CH2â€”(CH2)uâ€”Oâ€”)mâ€”CH2â€”CH(OH)â€”CH2â€”â€ƒâ€ƒ(XIV) or is a polyoxyalkylene bridge member of the formula XVâ€”COâ€”(CH2)uâ€”Oâ€”(CH2â€”(CH2)uâ€”Oâ€”)mâ€”(CH2)uâ€”COâ€”â€ƒâ€ƒ(XV) or is a polyoxyalkylene bridge member of the formula XVIâ€”Yâ€”Oâ€”CO(CH2)uâ€”Oâ€”(CH2â€”(CH2)uâ€”Oâ€”)mâ€”(CH2)uâ€”COOâ€”Yâ€”â€ƒâ€ƒ(XVI) or is a polyoxyalkylene bridge member of the formula XVIIâ€”(CH2)kâ€”CH(R12)â€”COâ€”B1â€”(CnH2nâ€”Oâ€”)mâ€”CnH2nâ€”B1â€”COâ€”CH(R12)â€”(CH2)kâ€”â€ƒâ€ƒ(XVII) or is a polyoxyalkylene bridge member of the formula XVIII or is a polyoxyalkylene bridge member of the formula XIXâ€”Yâ€”Oâ€”COâ€”(CH2)2â€”NHâ€”(CnH2nâ€”O)mâ€”CnH2nâ€”NH â€”(CH2)2COOâ€”Yâ€”â€ƒâ€ƒ(XIX) or is a polyoxyalkylene bridge member of the formula XXIâ€”CH(CH3)â€”CH2â€”(Oâ€”CH(CH3)â€”CH2)aâ€”(Oâ€”CH2â€”CH2) bâ€”(Oâ€”CH2â€”CH(CH3)câ€”â€ƒâ€ƒ(XXI) in which: a+c=2.5 and b=8.5 to 40.5 or a+c=2 to 33 and b=0;R7 is hydrogen, halogen, C1-C4alkyl, C1-C8alkoxy or C3-C6alkenoxy; R8 is hydrogen, C1-C12alkyl, aryl-C1-C4alkyl or C5-C12cycloalkyl; R12 is hydrogen or C1-C16alkyl; R13 is halogen or â€”Oâ€”R14; R14 is hydrogen, C1-C8alkyl, C3-C6alkenyl, aryl or aryl-C1-C4-alkyl; R15 is hydrogen, C1-C12alkyl or aryl; R16 is C1-C18alkyl, C5-C12cycloalkyl, C3-C6alkenyl, C1-C12alkylaryl or aryl-C1-C4alkyl; R17 is hydrogen or C1-C4alkyl; R21 is hydrogen, C1-C4alkyl or CN; Y is unsubstituted or substituted C2-C20alkylene; k is zero or a number from 1-16, m is a number from 2-60, n is the numbers 2 to 6, p is a number from 2-12, q is a number from 1-6, r is zero or 1, t is zero, 1 or 2, and u is a number from 1-4.