Patent ID: 6117896
Filing Date: 2000-09-12
Classification: A61K,C07K

Abstract:
A method for inhibiting a transcription factor, comprising administering to an animal in need thereof an effective amount of a compound having the structure: ##STR860## or a pharmaceutically acceptable salt thereof, whereinC is --(CH.sub.2).sub.0-3 --;F is an optional carbonyl moiety;R.sub.1 and R.sub.4 are independently selected from amino acid side chain moieties and derivatives thereof;R.sub.2 represents one or more ring substituents individually selected from an amino acid side chain moiety and derivatives thereof, or R.sub.2 taken together with C or Y forms a fused substituted or unsubstituted homocyclic or heterocyclic ring;R.sub.3 is selected from an amino acid side chain moiety and derivatives thereof, or taken together with C forms a bridging moiety selected from --(CH.sub.2).sub.1-2 --, --O-- and --S--;Y and Z represent the remainder of the molecule; andany two adjacent CH groups of the bicyclic ring may form a double bond.