Patent ID: 6475997
Filing Date: 2002-11-05
Classification: A61K,A61P,C07K

Abstract:
A method of treating an infection comprising:administering to a mammal in need of such treatment a DNA molecule encoding a single chain Fc receptor that comprises the cytoplasmic domain of Fc&ggr;RIIA and that, upon production in a host cell, increases the phagocytic potential of said host cell, wherein said DNA molecule is present in a liposome or a viral vector and said administration is effected under conditions such that: i) said DNA molecule is expressed in macrophages, epithelial cells or fibroblasts of said mammal, ii) said Fc receptor is produced, and iii) the phagocytic potential of said macrophages, epithelial cells or fibroblasts of said mammal is thereby increased, and wherein said macrophages, epithelial cells or fibroblasts of said mammal phagocytose particles causing said infection so that said treatment is effected.