Patent ID: 6387636
Filing Date: 2002-05-14
Classification: B01J,C40B

Abstract:
A method of fabricating a biopolymer array from biomonomers comprising the steps of:(a) depositing a biomonomer in solution onto a substrate for linking the biomonomer to a surface of the substrate in an array pattern of features; (b) deprotecting the linked biomonomer, such that the linked biomonomer can react with subsequent biomonomers in solution; (c) depositing a subsequent biomonomer in solution onto the features, the subsequent biomonomer being activated for attachment to the linked biomonomer on the array feature by an activation reagent, the subsequent biomonomer becoming the linked biomonomer upon attachment; (d) applying a non-miscible fluid (NMF) over the features on the surface of the substrate before or after any of the above steps (a) to (c), the NMF being inert and insoluble with the biomonomer solution, the activation reagent, the activated biomonomer and the linked biomonomer; and (e) repeating at least step (c) until the biopolymer is synthesized at each feature.