Patent ID: 7737088
Filing Date: 2010-06-15
Classification: B01J,B01L,B82Y,C12N,C12P,C40B,G01N,G03F,Y10S

Abstract:
1. A method of biochip manufacture, which comprises (a) providing a programmable illumination matrix and a light sensor detection matrix, wherein said illumination matrix and said detection matrix are arranged facing each other such that the detection matrix is situated in the light path of the illumination matrix and such that the detection matrix can detect light from the illumination matrix; (b) positioning a transparent biochip carrier, wherein said carrier has a surface that comprises photoactivatable cleavable protective groups located thereon for photochemical synthesis at predetermined areas of said biochip carrier surface, between said illumination matrix and said detection matrix and in the light path of said illumination matrix such that light from the illumination matrix illuminates and is transmitted through said biochip carrier and to said detection matrix; (c) specifically illuminating said biochip carrier to produce an adjustable two-dimensional light exposure pattern that illuminates selected predetermined areas of said biochip carrier; (d) monitoring and controlling the quality of said specific two-dimensional light exposure pattern by detecting the location of the illuminated areas of said two-dimensional light exposure pattern on said biochip carrier using the detection matrix and adjusting said two-dimensional light exposure pattern where appropriate, taking into account the information obtained by said monitoring.