Patent ID: 7943154
Filing Date: 2011-05-17
Classification: A61K,A61P,Y10S

Abstract:
1. Process for the preparation of storage-stable, multiple emulsions of the water/oil/water (W/O/W) type which comprise one or more active ingredients with the steps a) stirring the active ingredient into an aqueous phase comprising a substance selected from the group consisting of boric acid, phosphoric acid, N-2-(acetamido)-2-aminoethanesulphonic acid, N-2-(acetamido)-2-iminodiacetic acid, alanine, 2-amino-2-methyl-1,3-propanediol, ammonia, N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid, N,N-bis(2-hydoxyethyl) glycine, 2,2-bis(hydroxyethyl)iminotris(hydroxymethyl)methane, 2-(cyclohexylamino) ethanesulphonic acid, 3-[4-(2-hydroxyethyl)1-piperazinyl]-propanesulphonic acid, histidine, imidazole, lactic acid, 2-morpholinoethane-sulphonic acid, 2-morpholinopropanesulphonic acid, piperazine-1,4-bis(2-ethane-sulphonic acid), N[tris(hydroxymethyl)methyl]-2-aminoethanesulphonic acid, N-[tris(hydroxymethyl)methyl] glycine, triethaneolamine, tris(hydroxymethyl)amino-methane, 2-[4-(2-hydroxyethyl)piperazin- 1-yl] ethanesulfonic acid, and citric acid, b) emulsifying the aqueous phase by passing the aqueous phase through a porous membrane having a pore size of 0.2 to 5 μm into an oil phase comprising a mineral oil, white oil, or vegetable oil, wherein the aqueous and oil phases are heated to a temperature of from 30° C. to 35° C. before said emulsification, and c) phase inversion of the heated emulsion from b), by cooling the mixture at a cooling rate of at least 0.3 K/min, where a non-ionic emulsifier is added to the oil phase in b).