Patent ID: 6300501
Filing Date: 2001-10-09
Classification: A61K,C07K

Abstract:
A compound having the Formula I ##STR37##whereinR.sup.21 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.Q is ##STR38##n is 0 or 1;A is --COR.sup.a, --CO.sub.2 R.sup.a', --CONHR.sup.a', --CSR.sup.a, ##STR39##--C(S)OR.sup.a', --C(S)NHR.sup.a', --SO.sub.2 R.sup.a, --CONR.sup.a R.sup.a"", or ##STR40##R.sup.a, R.sup.a', and R.sup.a"" are independently C.sub.1 -C.sub.6 alkyl, --(CH.sub.2).sub.m -cycloalkyl, --(CH.sub.2).sub.m -aryl, or --(CH.sub.2).sub.m -heteroaryl;each m is independently 0 to 3;R.sup.1, R.sup.2, and R.sup.4 are independently hydrogen or C.sub.1 -C.sub.6 alkyl; ##STR41##--(CH.sub.2).sub.m -heteroaryl, ##STR42##--(CH.sub.2).sub.m -naphthyl, --(CH.sub.2).sub.m -(heteroaryl substituted with R.sup.b), or C.sub.1 -C.sub.6 alkyl;t is 2 to 6;R.sup.b is --O-phenyl, --O-benzyl, halogen, C.sub.1 -C.sub.6 alkyl, hydrogen, --OC.sub.1 -C.sub.6 alkyl, --NH.sub.2, ##STR43##--O--(CH.sub.2).sub.y NR.sup.a R.sup.a', --(CH.sub.2).sub.m -aryl, --O--(CH.sub.2).sub.m -aryl, --(CH.sub.2).sub.m -heteroaryl, --O--(CH.sub.2).sub.m -cycloalkyl, or --(CH.sub.2).sub.m -cycloalkyl;y is 2 or 3;R.sup.5 is ##STR44##R.sup.i, R.sup.g, and R.sup.h are independently hydrogen, halogen, --OC.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyl, --CN, --OPO.sub.3 H.sub.2, --CH.sub.2 PO.sub.3 H.sub.2, --O-phenyl, --O-benzyl, ##STR45##--N.sub.3, --CF.sub.2 CF.sub.3, --SO.sub.2 R.sup.a, --SO.sub.2 NR.sup.a R.sup.a', --CHO, or --OCOCH.sub.3 ; andR.sup.c, R.sup.d, R.sup.e, and R.sup.f are independently C.sub.1 -C.sub.6 alkyl, --(CH.sub.2).sub.m -phenyl, hydrogen, --(CH.sub.2).sub.m -OH, --(CH.sub.2).sub.m -cycoalkcyl-(CH.sub.2).sub.m NH.sub.2, or --CN, provided that R.sup.g, R.sup.h andR.sup.i are not all hydrogen when R.sup.21, R.sup.4 and R.sup.c to R.sup.f are all hydrogen, or the pharmaceutically acceptable salts, esters, amides, or prodrugs thereof.