Patent ID: 6100246
Filing Date: 2000-08-08
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR10## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring having 1 to 3 nitrogen atoms, or a five membered heterocyclic aromatic ring having 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S;R.sup.2 and R.sup.3 independently represent hydrogen, C1 to 6 alkyl, C1 to 6 alkoxy, C1 to 6 alkylthio, halogen, hydroxy or amino;R.sup.1 represents(i) phenyl; a six membered heterocyclic aromatic ring having 1 to 3 nitrogen atoms; or a five membered heterocyclic aromatic ring having 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S, the phenyl or heterocyclic aromatic ring being unsubstituted or substituted by C1 to 6 alkyl, C1 to 6 alkoxy, C1 to 6 alkylthio, C2 to 6 alkenyl, C2 to 6 alkynyl, C1 to 6 haloalkyl, C2 to 12 alkoxyalkyl, C2 to 12 alkylthioalkyl, amino, halogen, hydroxy, cyano or nitro; or(ii) OR.sup.4, where R.sup.4 represents C1 to 6 alkyl, C2 to 6 alkenyl, C2 to 6 alkynyl, C1 to 6 haloalkyl, C2 to 12 alkoxyalkyl, C2 to 12 alkylthioalkyl, C7 to 12 arylalkyl or C7 to 12 aryloxyalkyl;X represents CH.sub.2, CO, 0 or S(O).sub.n where n represents an integer from 0 to 2; or a pharmaceutically acceptable salt, enantiomer or tautomer thereof.