Patent ID: 7601493
Filing Date: 2009-10-13
Classification: C12Q,Y10T

Abstract:
1. A method for detecting a polymorphism related to a genetic disease in a patient sample nucleic acid, comprising the steps of: providing the patient sample nucleic acid containing a first locus having a first polymorphism and a second locus having a second polymorphism on a site of a microarray, wherein the first or second polymorphism is related to the genetic disease; providing an unlabeled blocker that is complementary to the first locus containing the first polymorphism; hybridizing the unlabeled blocker with the first locus such that the first polymorphism is blocked by the unlabeled blocker and the second locus is unblocked; providing a detectable discriminator that is capable of hybridizing with the second locus containing the second polymorphism and specifically identifying the second polymorphism; hybridizing the detectable discriminator with the second locus containing the second polymorphism; and detecting the second polymorphism by detecting the presence of the discriminator at the site of the microarray.