Patent ID: 9074254
Filing Date: 2015-07-07
Classification: A61P,C12Q

Abstract:
1. A method of administering a compound to a human individual, the method comprising: determining, or having determined, from a biological specimen obtained from the individual, the individual's genotype at the single nucleotide polymorphism (SNP) locus rs993648; in the case that the individual's genotype at the rs993648 locus is AG and not associated with an increased risk of QT prolongation, administering to the individual a first quantity of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt thereof; and in the case that the individual's genotype at the rs993648 locus is non-AG and associated with an increased risk of QT prolongation, administering to the individual a second quantity of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt thereof that is less than the first quantity that would be administered to an individual having an AG genotype at the rs993648 locus.