Patent ID: 6307087
Filing Date: 2001-10-23
Classification: C07C,C07D,C07F

Abstract:
The ligand represented by structure 1: ##STR142##whereinA and B independently represent fused rings selected from the group consisting of monocyclic or polycyclic cycloalkyls, cycloalkenyls, aryls, and heterocyclic rings, said rings having from 4 to 8 atoms in a ring structure;X represents NR.sub.2, P(alkyl).sub.2, P(cycloalkyl).sub.2, AsR.sub.2, or OR;Y represents H, alkyl, NR.sub.2, or AsR.sub.2 ;X and Y are not identical;R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4, for each occurrence, independently represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine, acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80 ;R.sub.5 and R.sub.6, for each occurrence, independently represent halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine, acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or --(CH.sub.2).sub.m --R.sub.80 ;A and B independently are unsubstituted or substituted with R.sub.5 and R.sub.6, respectively, any number of times up to the limitations imposed by stability and the rules of valence;R.sub.1 and R.sub.2, or R.sub.3 and R.sub.4, or both, taken together optionally represent a ring having a total of 5-7 atoms in the backbone of said ring; said ring having zero, one or two heteroatoms in its backbone; and said ring is substituted or unsubstituted;R.sub.80 represents an unsubstituted or substituted aryl, cycloalkyl, cycloalkenyl, heterocycle, or polycycle;m is an integer in the range 0 to 8 inclusive; andthe ligand, when chiral, is a mixture of enantiomers or a single enantiomer.