Patent ID: 7109358
Filing Date: 2006-09-19
Classification: A61P,C07D

Abstract:
1. A process for the preparation of 2H-isoflavones of formula I which process comprises the reaction of a 2-hydroxyaryl alkyl ketone of formula II in the presence of a base with a formic-sulfuric anhydride salt of formula III and which reaction is followed by neutralization, wherein formula I is wherein R3 is hydrogen, hydroxyl or alkoxyl, alkyl, substituted alkyl, or unsaturated alkyl, when R3 is not hydrogen or hydroxyl then the atoms comprising the substituent may comprise a heterocyclic ring of oxygen and carbon atoms attached to position 4 of the ring which rings may be saturated or unsaturated and optionally substituted with alkyl groups; R4 is hydrogen, hydroxy or alkoxyl, when R4 is alkoxyl then the elements of the substituent may comprise a heterocyclic ring of carbon and oxygen atoms attached to positions 3 or 5 which may be saturated or unsaturated and optionally substituted with alkyl groups; R5 is hydrogen, hydroxyl, alkoxyl, alkyl, substituted alkyl, or unsaturated alkyl, when R5 is not hydrogen or hydroxyl then the atoms of the substituent may comprise a heterocyclic ring of carbon and oxygen atoms attached to the ring at position 4 to form saturated or unsaturated rings such methylenedioxy or dihydofuran, dihydropyran, or pyrene rings which rings themselves may be substituted with alkyl groups; R6 is hydrogen, hydroxyl, alkoxyl, alkyl or substituted alkyl; R2′ is hydrogen, hydroxyl, alkoxyl, alkyl, substituted alkyl, or unsaturated alkyl; R3′ is hydrogen, hydroxyl, alkoxyl, alkyl, substituted alkyl or unsaturated alkyl, when R3′ is not hydrogen or hydroxyl, the atoms of the substituent may comprise a heterocyclic ring of carbon and oxygen atoms attached to position 2′ or 4′ which ring maybe saturated or unsaturated and may be substituted with alkyl groups; R4′ is hydrogen, hydroxyl, or alkoxyl, when R4′ is not hydrogen or hydroxyl the elements of the substituent may comprise a heterocyclic ring of carbon and oxygen which are attached at position 3′ or 5′, which ring may be saturated or unsaturated and is optionally substituted with alkyl groups; R5′ is hydrogen, hydroxyl, alkoxyl, alkyl, substituted alkyl or unsaturated alkyl, when R5′ is not hydrogen or hydroxyl, the atoms of the substituent may comprise a heterocyclic ring of carbon and oxygen atoms attached to position 4′, which ring may be saturated or unsaturated and may be substituted with alkyl groups; R6′ is hydrogen, hydroxyl, alkoxyl, alkyl, substituted alkyl, or unsaturated alkyl; formula II is wherein the substituents have the meaning as defined above; and formula III is wherein X is a metallic cation, ammonium, an amine salt, salt of a heterocyclic base, quaternary ammonium or phosphonium salt including polymeric or polymer bound forms thereof; n is an average number of 1 to 4.