Patent ID: 8309720
Filing Date: 2012-11-13
Classification: A61P,C07C,C07D

Abstract:
1. A process for the preparation of a compound of formula (I) wherein L R R R Z is selected from the group consisting of N and CH; n is 1 or 2; R 9 , R 10 and R 11 are each independently selected from the group consisting of hydrogen and C 1-4 -alkyl; and pharmaceutically acceptable salts thereof; comprising reacting a compound of formula (V) wherein PG de-protecting the compound of formula (VII), to yield the corresponding compound of formula (VIII); and reacting the compound of formula (VIII) with a compound of formula (IX), in a second organic solvent, to yield the corresponding compound of formula (I), wherein X is selected from the group consisting of —N(R