Patent ID: 9161916
Filing Date: 2015-10-20
Classification: A61K,A61P,Y10S

Abstract:
1. A topical composition comprising a foamable pharmaceutical composition and a propellant, the foamable pharmaceutical composition comprising: a) an unstable active agent; b) at least one emollient; or c) at least one surfactant, wherein the surfactant comprises a fatty acid ester having a C8-C24 hydrocarbon chain; and d) optionally at least one foam adjuvant; wherein each component is compatible with the unstable active agent present in the composition; wherein the composition is free of one or more of PPG-15 stearyl ether, octyldodecanol, ethanol propylene glycol, glycerol, PEG 200, PEG 400, MCT oil, isostearic acid, polyoxyl 20 stearyl ether, polyoxyl 2 stearyl ether, methyl glycose sesquistearate, PEG 40 stearate, cocoglycerides, hexylene glycol, butylene glycol, sorbitan monolaurate, and dimethyl isosorbide, wherein the composition comprises less than about 2% by weight of the foamable pharmaceutical composition of water; and wherein at least 90% by mass of the unstable active agent is present in the foamable pharmaceutical composition when stored for 72 hours at 25° C. after mixing with the pharmaceutical composition.