Patent ID: 8222215
Filing Date: 2012-07-17
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating an autoimmune disease responsive to the inhibition of antigen binding to a MHC class II molecule comprising administering to a patient having an autoimmune disease responsive to the inhibition of antigen binding to a MHC class II molecule a compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: R X X R Het is heteroalkyl, aminoalkyl, alkylamido, or a substituted or unsubstituted heterocyclic ring; R Z is linear or branched alkyl; or Z taken together with W can form a substituted or unsubstituted 6-7 membered heterocyclic ring; W is linear or branched alkyl when Z is linear or branched alkyl, substituted or unsubstituted aryl or substituted or unsubstituted arylalkyl; A is a substituted or unsubstituted 5-7 membered heteroaryl ring, a substituted or unsubstituted aryl ring, a substituted or unsubstituted 9-14 membered bicyclic ring; or a substituted or unsubstituted 13-17 membered tricyclic ring; m is an integer selected from 0 and 1; n is an integer selected from 0 and 1; t is an integer selected from 0, 1 and 2; p is an integer selected from 0 and 1; and wherein the compounds of formula II contain 0, 1, 2 or 3 residues in the D configuration and the remaining residues are in the L configuration.