Patent ID: 6495546
Filing Date: 2002-12-17
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of the general formula (I): whereinR1 is aryl which may have one or more suitable substituent(s), heterocyclic group or cyclo(lower)alkyl, R2 is hydrogen or amino protective group, R3 and R4 are independently hydrogen, halogen, hydroxy, amino, nitro, carboxy, protected carboxy, aryl, lower alkyl, hydroxy(lower)alkyl, amino(lower)alkyl, acyloxy(lower)alkyl, acylamino(lower)alkyl, lower alkylamino(lower)alkyl which may have one or more suitable substituent(s), mono or di-(lower)alkylamino, acylamino, acyl group, lower alkoxy, halo(lower)alkoxy, lower alkenyloxy, lower alkoxy(lower)alkoxy, aryloxy, cyclo(lower)alkyloxy, heterocyclicoxy, ar(lower)alkyloxy, acyloxy or acyl(lower)alkoxy, R5 is hydrogen, lower alkyl, or aryl, A is lower alkylene which may have one or more suitable substituent(s) or lower alkenylene, X is O, S, SO, SO2 or NH, and m is an integer of 0 or 1, or a salt thereof, wherein when R1 is naphthyl and R5 is H, then X is not O.