Patent ID: 6207700
Filing Date: 2001-03-27
Classification: A61K,A61P

Abstract:
A method for cancer treatment in a warm blooded vertebrate animal, comprising administering to the animal a treatment effective amount sufficient to inhibit cancer of a carboxylic acid secondary amide derivative of a compound, wherein:(1) the secondary amide derivative (a) is selective for inhibition of cyclooxygenase-2, and (b) has an indole system, where the indole system has a nitrogen and the indole nitrogen is substituted with para-halobenzoyl, where the halo is selected from the group consisting of fluoro, chloro, and bromo, and(2) the compound (a) is a cyclooxygenase inhibitor but is absent selectivity for inhibition of cyclooxygenase-2 and (b) contains a carboxylic acid moiety or a pharmaceutically acceptable salt thereof.