Patent ID: 9145353
Filing Date: 2015-09-29
Classification: C07B,C07C

Abstract:
1. A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride, comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride, where the compound (1) has a structural formula of: and the compound (II) has a structural formula of: wherein in the step 2, the reducing agent is selected from the group consisting of NaBH