Patent ID: 7001924
Filing Date: 2006-02-21
Classification: A61K,C07C

Abstract:
1. A method of killing or inhibiting the growth of bacteria, said method comprising contacting bacteria or a site susceptible to bacterial growth with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula I: or a derivative, salt, racemic mixture, mixture of E/Z isomers, or mixture of diastereomers thereof; wherein U 1 and U 2 are independently carbonyl, thiocarbonyl, or sulfonyl; k, l, m, and n are independently 0 or 1; A is a linker of 1, 2, 3, 4, 5, 6, 7, or 8 atoms that is optionally substituted with a group selected from alkyl, heteroalkyl, alkene, heteroalkene, alkyne, heteroalkyne, aryl, alkaryl, and heteroaryl; R′, R″, R 1 , and R 2 are independently H, alkyl, heteroalkyl, alkene, heteroalkene, alkyne, heteroalkyne, aryl, or heteroaryl; Y is selected from the group consisting of formulas II, III, IV, V, VI, VII, VIII, IX, and X; and Z is selected from the group consisting of substituted phenyl and formulas II, III, IV, V, VI, VII, VIII, IX, X, and XI: wherein each R