Patent ID: 8455518
Filing Date: 2013-06-04
Classification: A61K,A61P,A61Q,C07C,C12Q

Abstract:
1. A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof an effective amount of an active agent that suppresses miR-29a, having the sequence UAGCACCAUCUGAAAUCGGUUA (SEQ. ID. No.: 1), and/or miR-29b, having the sequence UAGCACCAUUUGAAAUCAGUGUU (SEQ. ID No.: 2), in a cosmetically acceptable vehicle, for a time sufficient to enhance the production of collagen, elastin, and/or fibrillin in the skin, wherein said active agent is a compound having the structure of formula I: where: R R R R R, R*, and R X “n” is an integer from 0 to 3, and, in the case where “n” is 2 or 3, R and cosmetically acceptable acid addition salts thereof.