Patent ID: 6413521
Filing Date: 2002-07-02
Classification: A61K,C07K,C12N

Abstract:
An isolated and purified antigen conferring protective immunity against a non-obligate blood feeding helminth and which is characterized by possessing aminopeptidase M-like activity which can be assayed using an alanine, leucine or methionine p-nitroanilide substrate or aminopeptidase A-like activity which can be assayed using an &agr;-glutamic acid nitroanilide substrate and which, in native form, is an integral membrane protein associated with the gut microvilli of a non-obligate blood feeding helminth parasite of the genus Ostertagia or Cooperia and being derived from and capable of conferring protective immunity against a non-obligate blood feeding helminth, wherein said antigen is obtainable from Ostertagia and has an apparent molecular weight (Mr) of about 124,000 to 126,000, as determined by SDS-PAGE on a 6-16% gel under denaturing conditions.