Patent ID: 6780995
Filing Date: 2004-08-24
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for the synthesis of a compound selected from the group consisting of (a), (b) and (c) below:(a) compounds having Formula I: wherein:R4 is (i)â€”CH2CH&boxH;CH2; (ii)â€”CH2Câ‰¡CH; (iii)â€”NHCâ‰¡CH; (iv)â€”NHCH&boxH;CH2; (v)â€”NHCH2CH2N(CH2CH3)2; (vi)â€”NHCH2CH2N(CH3)2; (vii)â€”OH; (x)â€”(CH2)aN(R5)(R6) wherein a=1 or 2 and R5 and R6 are H or lower alkyl; wherein R7 is H or CF3; wherein X is H, NO2, â€”COOCH3, â€”COOCH2CH3, CH2CH3, or CH3 and R8 is H, CH3, or wherein X is H, NO2, â€”COOCH3, or CH3 and R8 is H or CH3; wherein R7 is H or CF3; (b) Compounds having Formula II: wherein Z is: and said method comprising:(1) synthesizing a 2-iodo-5-nitrobenzoic acid; and (2) attaching to the carbonyl group of the 2-iodo-5-nitrobenzoic acid the following for the preparation of compounds in groups (a), (b) and (c), respectively: (a)â€”NHR4;