Patent ID: 6515134
Filing Date: 2003-02-04
Classification: C07D

Abstract:
A production method of an optically active hydroxyethyl pyridine derivative represented by the general formula (10): in the formula, X represents a hydrogen, a halogen, a hydroxyl group, an acyloxy group containing 1 to 10 carbon atoms, an alkoxy group containing 1 to 10 carbon atoms, an amino group or a substituted amino group, Y1 represents a halogen, a hydroxyl group, an acyloxy group containing 1 to 10 carbon atoms, a sulfonyloxy group containing 1 to 10 carbon atoms, an alkoxy group containing 1 to 10 carbon atoms, an amino group, an alkylamino group containing 1 to 15 carbon atoms, an aralkylamino group containing 1 to 15 carbon atoms, a sulfanyl group, an alkyl sulfanyl group containing 1 to 10 carbon atoms or anaralkyl sulfanyl group containing 1 to 10 carbon atoms and * represents an asymmetric carbon atom,which comprises using a microorganism-derived carbonyl reducing enzyme or a culture of a microorganism having an ability of producing said carbonyl reducing enzyme or a treatment product thereof to thereby (R)-selectively reduce a substituted acetylpyridine derivative represented by the general formula (9): in the formula, X and Y1 are as defined above.