Patent ID: 6794384
Filing Date: 2004-09-21
Classification: A61K,A61P

Abstract:
A CYP1B1 substrate comprising a chemical moiety bound to a carrier framework having the formula (Z): wherein:X=OH, OMe or N(CH3)2; and n=0-3; and;R1=H, C1-4 lower alkyl, or together with R2 forms part of a cycloalkyl group which may be further substituted to form part of a polycyclic cycloalkyl group; R2=H, OMe, C1-4 lower alkyl, or together with R1 and/or R3 forms part of a cycloalkyl, polycyclic cycloalkyl, or forms part of a polycyclic aromatic group by linkage to R4; R3=H, OMe, C1-4 lower alkyl or together with R2 forms part of a cycloalkyl, polycyclic cycloalkyl; and R4=H or is fused directly to the aromatic position designated by R2; either: the chemical moiety is derived from a chemical having a free amino, hydroxyl or thiol group and which links it to the rest of the CYP1B1 substrate, such that A represents NH, NR (R=C1-4 lower alkyl), C or S; or the chemical moiety is derived from a chemical having a carboxylate group, an ester linkage joining it to the rest of the CYP1B1 substrate and A being nothing; and the chemical moiety is selected from the group consisting of a calchone moiety, a colchicine moiety, a stilbene moiety, a daunomycin moiety, an esperimycin moiety, a nitrogen mustard moiety, a staurosporin moiety, a taxol moiety, and a fluorophore moiety.