Patent ID: 7351567
Filing Date: 2008-04-01
Classification: A61P,C12P

Abstract:
1. A process for preparing a compound of the formula: wherein: A is selected from CH B, D and F are independently selected from CH and N; Y is Z G is Z W is R is hydrogen or C R R R R R a ring formed by R e is 0, 1 or 2; m is 1, 2 or 3; n is 0, 1 or 2; p is 0, 1, 2 or 3; q is 0, 1, 2 or 3; and optical and geometric isomers thereof; comprising enzymatically resolving of a compound of the formula wherein R 1 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl wherein the alkyl, alkenyl or alkynyl groups are optionally substituted by one to three halo in the presence of a lipase and an aqueous buffer solution; and (b) reacting the compound of formula IV so formed wherein R 1 is as defined above, with a base in the presence of a polar protic solvent.