Patent ID: 7241595
Filing Date: 2007-07-10
Classification: A61K,B82Y,C07H,C07K,C12N,C12Y

Abstract:
1. A process for the preparation of a compound of the formula I: in which Me is methyl; R R R R R R R R wherein the acyl protective group is an acetyl group, mono-, di- or trihalogenoacetyl group; which comprises reacting, in the presence of a promoter selected from the group consisting of BF 3 x ether, tri-C 1 -C 4 -alkylsilyl trifluoromethane sulfonate, salts of silver and salts of mercury in a solvent selected from the group consisting of acetone, ethyl acetate, ether, toluene, dichloromethane, dichloroethane and mixtures thereof at −50° C. to 60° C., an etoposide compound of the formula VI: in which Me is methyl; R R R R with a carbohydrate component of the formula VII: in which R R R R Z is a halogen atom, hydroxyl group, tri-C wherein the acyl protective group is an acetyl group, mono-, di- or trihalogenoacetyl group, to give a 4′-O-glycosyl-etoposide derivative of the formula I in which all the radicals R 1 to R 8 retain their meaning as defined above, and eliminating the protective groups present in the 4′-O-glycosyl-etoposide derivative by hydrogenolysis or hydrolysis.