Patent ID: 8496945
Filing Date: 2013-07-30
Classification: A61K,A61P

Abstract:
1. A method to prepare a composition comprising nanoparticles, which nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer, wherein said lipid/surfactant layer contains at least one membrane-integrating peptide and optionally a targeting ligand, which method comprises incubating nanoparticles comprising a hydrophobic core coated with a lipid/surfactant layer, optionally containing a targeting ligand, with at least one membrane-integrating peptide, wherein the membrane-integrating peptide comprises a hydrophobic amino acid sequence of 10-30 amino acids adjacent to a cationic amino acid sequence of 3-6 amino acids, and is a membrane lytic or membrane pore-forming peptide.