Patent ID: 6410802
Filing Date: 2002-06-25
Classification: A61P,C07C,C07D,C07F,Y10S

Abstract:
A method for synthesizing a compound of a formula II: comprising: (a) contacting in the presence of a base a compound of a formula XXIV: with a compound of a formula XXVIII to provide a compound of a formula XXIX and; (b) deprotecting the compound of the formula XXIX to provide the compound of the formula II, wherein:R1, R2, R3, and R4 are independently selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, and benzyl; or R1, R2, and the carbon to which they are attached are taken together to form a (C3-C7)cycloalkyl group; or R3, R4, and the carbon to which they are attached are taken together to form a (C3-C7)cycloalkyl group; with the proviso that none of R1, R2, R3, or R4 is â€”(CH2)0-4Câ‰¡CH; X is a halide or sulfonate; and PG is a hydroxy protecting group.