Patent ID: 7235530
Filing Date: 2007-06-26
Classification: A61K,A61P

Abstract:
1. A method for reducing blood loss in a patient comprising administering to the patient a non-naturally occurring kallikrein inhibitor polypeptide comprising the amino acid sequence Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp, (residues 3-60 of SEQ ID NO:2) in combination with an anti-thrombolytic agent, wherein said blood loss is perioperative blood loss due to a surgical procedure performed on the patient.