Patent ID: 8277802
Filing Date: 2012-10-02
Classification: A61K,A61P,C07K,C12Q

Abstract:
1. A method of reducing the invasivity of cancer cells in a subject in need thereof comprising administering to the subject an inhibitor of the AXL protein or GAS6, or any combination thereof, in an amount which is effective for reducing the invasivity of cancer cells, and wherein said inhibitor of the AXL protein is selected from the group consisting of anti-AXL antibodies or Fab, Fab′, Fab2 or scFV antigen binding fragments thereof, and wherein said inhibitor of GAS6 is selected from the group consisting of anti-GAS6 antibodies or Fab, Fab′, Fab2 or scFV antigen binding fragments thereof, and wherein said cancer cells are selected from the group consisting of kidney cancer cells and glioblastoma cells.