Patent ID: 6143151
Filing Date: 2000-11-07
Classification: C07D,C12Q,G01N,Y10S

Abstract:
Apparatus comprising:means for performing gel electrophoresis;said means for performing gel electrophoresis having at least four identical separating channels;each of said at least four identical separating channels including a corresponding first end, second end and a central section;each of said first ends being adapted to receive DNA fragments terminated at least at one of four nucleic acid molecules, A, G, C, and T;said means for performing gel electrophoresis further including means for separating bands of the DNA fragments before reaching said second end of said means for performing gel electrophoresis wherein said bands are separated on line at said second end prior to the resolution of the larger molecular weight DNA fragments;means for identifying four separate groups of DNA fragments in the separated bands in accordance with the terminating base of the DNA fragments;each of said channels including at least one capillary tube;said means for performing gel electrophoresis further including means for establishing potential across said at least four identical separate channels, wherein bands of more mobile DNA fragments are fully resolved in the gel electrophoresis channels while some of the less mobile strands to be later formed into bands are unresolved in a continuous process; andsaid means for identifying including means for generating electrical signals indicating the time sequence of the marked bands of DNA corresponding to each of the DNA fragments terminated at different ones of the nucleic acid groups.