Patent ID: 7465547
Filing Date: 2008-12-16
Classification: A61P,C07K,G01N

Abstract:
1. A method of detecting human low-molecular-weight CD14 in a specimen, which comprises: contacting the specimen with: (a) an antibody that binds to a peptide consisting of the amino acid sequence of SEQ ID No:2; and (b) an antibody that binds to a peptide consisting of the amino acid sequence from position 17 to position 26 of SEQ ID NO:5; wherein said human low molecular weight CD 14: (1) is not bound by F1025-3-1 (Accession No. FERM BP-7296) antibody, (2) has a peak elution at a molecular weight range of 25 to 45 kDa as determined by gel filtration chromatography, and (3) is obtainable from human blood; and detecting binding of antibodies (a) and (b) to said human low-molecular-weight CD14, whereby said method can detect low-molecular-weight CD14 without detecting high-molecular-weight CD14.