Patent ID: 8906953
Filing Date: 2014-12-09
Classification: A61K,A61P,C07D

Abstract:
1. A method for the treatment of an inflammatory disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula 1; wherein Ar is a phenyl ring, wherein the phenyl ring is substituted with 1 or 2 identical or different substituents selected from: halogen, nitro, cyano, C wherein R or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof; wherein the inflammatory disorder is mediated by an inflammatory cytokine selected from the group consisting of tumor Necrosis Factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and interleukin-8 (IL-8), and the said inflammatory disorder is selected from the group consisting of rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, refractory rheumatoid arthritis and chronic non-rheumatoid arthritis.