Patent ID: 8518916
Filing Date: 2013-08-27
Classification: A61P,C07D

Abstract:
1. A compound of the Formula A wherein: R′ is absent or is selected from the group consisting of hydrogen and hydroxyl; Z is chosen from the group consisting of wherein X′ is chosen from the group consisting of O and CH R R R R R X is chosen from the group consisting of O and S; Y is absent or chosen from the group consisting of —SO m is 0, 1 or 2 n is 0, 1 or 2 o is 0 or 1 p is 0, 1, 2, 3, 4 or 5; ---- is an optional double bond with the proviso that there cannot be two or more optional double bonds present; represents the point of attachment to the nitrogen containing ring and; wherein the optional substitutents are selected from the group consisting of C wherein the optional substitutents are selected from the group consisting of oxo, nitro, halogen, cyano, hydroxy, —SO wherein the optional substitutents are selected from the group consisting of —O—(C enantiomers, diastereomers and N-oxides thereof; and pharmaceutically acceptable salts thereof; with the proviso that two heteroatoms may not be covalently bound to one another unless present in a heteroaromatic ring, a sulfonamide linkage or as an N-oxide; with the proviso that when Z is one of formulas ii or iii, R