Patent ID: 8906874
Filing Date: 2014-12-09
Classification: A61K,A61P,C12N

Abstract:
1. A method of suppressing a tumor cell growth in a human subject comprising the steps of: identifying the human subject in need for suppression of the tumor cell growth; and administering an expression vector in a therapeutic agent carrier complex to the human subject in an amount sufficient to suppress the tumor cell growth, wherein the expression vector expresses one or more shRNAs capable of inhibiting an expression of a target gene that is Stathmin 1 in the one or more target cells via RNA interference; wherein the one or more shRNAs comprise a bifunctional RNA molecule that activates a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of the target gene; wherein the inhibition results in an apoptosis, an arrested proliferation, or a reduced invasiveness of the tumor cells.