Patent ID: 8288396
Filing Date: 2012-10-16
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), or its pharmaceutically-acceptable salt, ester or N-oxide derivative: wherein, a and b each independently mean 0 or 1; A is an aryl or heteroaryl group, which is optionally substituted with a substituent selected from the group consisting of a halogen atom, a hydroxyl group, —(C═O) wherein the ring B is a 5-membered to 7-membered aliphatic ring condensed with the ring of a formula (b): wherein one or two or more methylene groups constituting the ring B are each independently replaced by an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, a carbonyl group or a group of —N(R 1b )—, and one or two or more methylene groups constituting the ring B are each independently optionally substituted with a halogen atom, a hydroxyl group, a —(C═O) a O b (C1-C6)alkyl group or a group of -Q 1b -N(R 2b )R 3b , wherein the alkyl group of the substituent is optionally substituted with a halogen atom or a hydroxyl group; Q R R R R R R R R R R T and U are each independently a nitrogen atom, or a methine group optionally substituted with a halogen atom, a hydroxyl group, a cyano group or a —(C═O)