Patent ID: 6451789
Filing Date: 2002-09-17
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:n represents 1, R1 represents hydrogen, aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched, or trifluoroacetyl, R2 represents linear or branched (C1-C6)alkyl, X represents oxygen, chlorine, OR3, SR4 or NOR5, wherein R3 represents hydrogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, or aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched, R4 represents hydrogen, linear or branched (C1-C6)alkyl, or aryl, R5 represents hydrogen or linear or branched C1-C6)alkyl optionally substituted by one or more identical or different groups selected from hydroxy, amino (optionally substituted by one or two linear or branched C1-C6)alkyl groups), and linear or branched C1-C6)alkoxy,  represents a single or double bond, it being understood that the valency of the atoms is respected, Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically-acceptable acid, on the understanding that the term â€œarylâ€  means phenyl, biphenylyl, naphthyl, or tetrahydronaphthyl, each of those groups being optionally substituted by one or more identical or different groups selected from halogen, linear or branched C1-C6)alkyl, hydroxy, linear or branched C1-C6)alkoxy, trihalomethyl, and amino (optionally substituted by one or more linear or branched C1-C6)alkyl groups),and that the term â€œheteroarylâ€  denotes an aromatic, mono- or bi-cyclic, 5- to 12-membered group containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, it being understood that the heteroaryl group may be optionally substituted by one or more identical or different groups selected from halogen, linear or branched C1-C6)alkyl, hydroxy, linear or branched C1-C6)alkoxy, trihalomethyl, and amino (optionally substituted by one or more linear or branched C1-C6)alkyl groups).