Patent ID: 8980287
Filing Date: 2015-03-17
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A method of treating or delaying the growth of an Anaplastic Lymphoma Kinase (ALK) protein expressing tumor comprising administering to a subject in need thereof a purified nucleic acid molecule comprising, i) a nucleotide sequence selected from the group consisting of the nucleotide of SEQ ID No.:2 encoding the intracytoplasmatic domain of an ALK protein lacking a tyrosine kinase domain and the nucleotide of SEQ ID NO.: 3, encoding the intracytoplasmatic domain of an ALK protein comprising an inactivating mutation in the catalytic domain; or ii) a nucleic acid sequence encoding the amino acid of SEQ ID NO.: 5, which is the intracytoplasmic domain of an ALK protein; wherein said purified nucleic acid molecule is administered in a therapeutically effective amount to treat or delay tumor growth.