Patent ID: 7641906
Filing Date: 2010-01-05
Classification: A61K,C12P

Abstract:
1. A method for inducing an immunological response against NTHi or M. catarrhalis comprising intranasal administration of an immunogenic composition comprising an effective amount of Nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) or Moraxella catarrhalis lipooligosaccharide (LOS), said LOS produced by Nontypeable Haemophilus influenzae or Moraxella catarrhalis , from which LOS at least one primary O-linked fatty acid has been removed to form detoxified LOS (dLOS) and an immunogenic carrier covalently linked thereto, and a mucosal adjuvant or delivery system; wherein said at least one primary O-linked fatty acid is removed by breaking the bond coupling said primary O-linked fatty acid to a 3-hydroxy group of diglucosamine; and wherein administration of said effective amount of NTHi LOS induces an immunological response against NTHi and administration of said effective amount of