Patent ID: 6362230
Filing Date: 2002-03-26
Classification: A61P,C07C,C07D

Abstract:
A method of treating Alzheimer's disease in a human which comprises administering an effective amount of a compound of the formula: in which:A represents CR5(X1R6) or C&boxH;NO(CH2)nR7; R1 represents hydrogen, or together with R5 a bond; R2 and R3 each independently represents hydrogen or (1-4C)alkyl, or together with the carbon atom to which they are attached form a (3-6C)cycloalkyl ring; R4 represents (1-6C)alkyl, (3-6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1-6C)alkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, (1-4C)alkylphenyl wherein the phenyl group is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or NR9R10 in which each of R9 and R10 independently represents (1-4C)alkyl or together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; R5 represents hydrogen, hydroxy, (1-4C)alkoxy, (1-4C)alkoxycarbonyl, or together with a substituent on R6 a bond, or together with R1 a bond; X1 represents a bond, or when R1 represents hydrogen, NHCO; R6 represents (3-8C)cycloalkyl or an unsubstituted or substituted aromatic or heteroaromatic group; n is an integer of from 1 to 4; and R7 is as defined for R6; or a pharmaceutically acceptable salt thereof.