Patent ID: 6255318
Filing Date: 2001-07-03
Classification: A61P,C07D

Abstract:
A method of inhibiting virus replication other than cytomegalovirus (CMV) replication in a mammal comprising administering to said mammal an anti-viral amount of a compound of formula (I): ##STR84##whereinW is selected from CH, CR.sub.3, CH.sub.2, C.dbd.O, CHR.sub.3, N and NR.sub.5 ; one of X, Y, and Z is N or NR.sub.5 while the other two are independently selected from CH, CR.sub.4, CH.sub.2, C.dbd.O and CHR.sub.4 ;Q is selected from CH, CR.sub.3, CH.sub.2, C.dbd.O, CHR.sub.3, N, NR.sub.5 and O;B is selected from the group consisting of: ##STR85##wherein,A is O, N or S;R.sub.1 is selected from:C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.3-7 cycloalkyl optionally substituted with OH, halogen amino, carboxyl, or saturated or unsaturated C.sub.3-10 carbocycle or C.sub.3-10 heterocycle optionally substituted with OH, halogen, amino, mercapto, carboxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 acyl, C.sub.1-4 acyloxy or C.sub.1-4 alkoxycarbonyl optionally substituted with OH, halogen, amino or C.sub.1-4 alkoxy;C.sub.3-7 cycloalkyl fused to C.sub.6-10 aryl optionally substituted with OH, halogen, amino, mercapto, carboxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 acyl, C.sub.1-4 acyloxy or C.sub.1-4 alkoxycarbonyl optionally substituted with OH, halogen, amino or C.sub.1-4 alkoxy, andsaturated or unsaturated C.sub.3-10 (carbocycle or heterocycle) optionally substituted with OH, halogen, amino, mercapto, carboxy, C.sub.1-4 (alkyl, alkoxy, alkylthio, acyl, acyloxy or alkoxycarbonyl) optionally substituted with OH, halogen, amino or C.sub.1-4 alkoxy;R.sub.2 and R'.sub.2 are independently selected from H, or C.sub.1-4 alkyl or R.sub.1 and R.sub.2 together form a saturated or unsaturated 5 or 6 member heterocycle optionally fused to C.sub.6-10 aryl or heteroaryl;R.sub.3 and R.sub.4 are independently selected from H, OH, halogen, amino, cyano, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, C.sub.1-6 acyl, C.sub.1-6 acyloxy or C.sub.1-6 alkoxycarbonyl optionally substituted with OH, halogen, amino or C.sub.1-4 alkoxy, and saturated or unsaturated C.sub.3-10 carbocycle or C.sub.3-10 heterocycle optionally substituted with OH, halogen, amino, mercapto, C.sub.1-4 alkylthio, C.sub.1-4 alkoxycarbonyl, halo-substituted C.sub.1-4 alkyl or halo-substituted C.sub.1-4 alkoxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or carboxy;R.sub.5 is H, C.sub.1-6 alkyl or C.sub.1-6 acyl optionally substituted with OH, halogen, amino or C.sub.1-4 alkoxy; andn is 1 or 2.