Patent ID: 9180102
Filing Date: 2015-11-10
Classification: A61K,B82Y,G03F

Abstract:
1. A method for making a plurality of monodisperse, solid particles comprising: placing, on a silicon substrate, a patternable biodegradable polymer comprising a therapeutic agent, an imaging contrast agent, or both incorporated into a polymer matrix of the polymer; placing a release layer on an imprint template; imprinting the polymer by pressing the release layer and imprint template into the polymer, thereby forming a plurality of monodisperse, solid particles between 50 nm and 1000 nm in size corresponding to a plurality of particle-shaped portions of the imprint template and containing the therapeutic agent, an imaging contrast agent, or both, and also forming a residual polymer layer on the silicon substrate; removing the imprint template; oxygen plasma cleaning the plurality particles and residual polymer layer on the silicon substrate to remove the residual polymer layer; and releasing the plurality of particles.