Patent ID: 9095624
Filing Date: 2015-08-04
Classification: A61K,A61P

Abstract:
1. A modular transport platform (MTP) comprising several functional polypeptide modules within one molecule, specifically configured to penetrate a target cell, deliver the modular transporting platform into the target cells, provide pH-dependent membrane disruption activity, directed intracellular transport into a target subcellular compartment of the target cell, and an active agent coupled within the modular transport platform, the molecule comprising: a first, heterologous module for a non-covalent coupling and having a hydrophobic pocket, the first, heterologous module being an a second, heterologous module prepared from a second sequence and configured to cause delivery of the MTP to a particular subcellular compartment, wherein the intracellular transport module delivers the MTP to the subcellular compartment based on one or more cellular transport mechanisms; a third, heterologous module prepared from a third sequence and configured to prolong the localization of the modular transport platform within the target subcellular compartment by binding to a component within the subcellular compartment to retain the MTP within the subcellular compartment or by undergoing a chemical modification within the subcellular compartment to impede the ability of the MTP to be exported from the targeted subcellular compartment.