Patent ID: 7820648
Filing Date: 2010-10-26
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 1-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-hydroxy-ethanone, 2-Amino-1-[6-(4-cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(5-Chloro-4-cyclobutylamino-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, N-{2-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide, 6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,2R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene-9-carboxylic acid ethyl-amide, 1-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-methoxy-ethanone, [6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-cyclopropyl-methanone, 1-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, N4-Cyclobutyl-N2-[(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-6-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine, (+/−)-1-[6-(4-Cyclopropylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclopropylamino-5-methyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclopropylamino-5-fluoro-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Ethylamino-5-methyl-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Ethylamino-5-fluoro-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-ethylamino-5-chloro-pyrimidin-2-ylamino)-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-{6-[5-Fluoro-4-((S)-2-methoxymethyl-pyrrolidin-1-yl)-pyrimidin-2-ylamino]-(1S,4R)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl}-ethanone, N4-Cyclobutyl-N2-[(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-6-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine, 1-[6-(4-Cyclobutylamino-5-methyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclobutylamino-5-fluoro-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, N-{2-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide, [6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-acetic acid methyl ester, [6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-(R)-pyrrolidin-2-yl-methanone, [6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-cyclopropyl-methanone, 1-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-methoxy-ethanone, 6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene-9-carboxylic acid isopropyl-amide, 1-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-methylamino-ethanone, 1-[6-(5-Chloro-4-cyclobutylamino-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclobutylamino-5-fluoro-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclobutylamino-5-ethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, 1-[6-(4-Cyclobutylamino-5-methyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-ethanone, N4-Cyclopropyl-N2-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-6-yl-5-trifluoromethyl-pyrimidine-2,4-diamine, N4-Cyclopropyl-N2-[(1R,4S)-9-methanesulfonyl-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-6-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine, 1-[6-(4-Cyclopropylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-(1R,4S)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-methoxy-ethanone, (+/−)-1-{6-[4-(2-Methoxy-ethylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl}-ethanone, (+/−)-2-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-N,N-dimethyl-acetamide, (+/−)-N-{2-[6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide, and pharmaceutically acceptable salts thereof of each of the foregoing compounds.