Patent ID: 6183754
Filing Date: 2001-02-06
Classification: C07K,C12N,C12Q,G01N

Abstract:
A purified polypeptide of viral origin inducible in human cells by human cytomegalovirus having: a molecular weight of about 68,000 daltons; is recognized by the monoclonal antibody produced in the hybridoma deposited in the C.N.C.M. (National Collection of Microorganisms and Cultures) under accession No. I-289; a protein-kinase activity of the casein-kinase II type; a capability of causing the transfer of phosphorus from ATP to casein, phosvitin, glycogen-synthetase, histones and alphaphosphorylases; a protein-kinase, activity which is inhibited by quercitin; a capability of being autophosphorylated in vitro; and a loss of activity at -70.degree. C. and at 100.degree. C., wherein said polypeptide of viral origin which is inducible in human cells by human cytomegalovirus persists throughout the infectious cycle.