Patent ID: 8642651
Filing Date: 2014-02-04
Classification: A61K,A61P

Abstract:
1. Method of manufacturing a nutritionally acceptable composition for mammalian consumption, comprising: combining a water soluble fraction of a cellular lysate with a chromium-3 + salt; reacting the water soluble fraction of the cellular lysate with the chromium-3.sup.+ salt to form a substantially completely water soluble chromium-3 + containing complex matrix; obtaining data that establish that potency of reduction of fasting blood glucose in vivo is dependent on an absorption maximum of the chromium-3 + -containing complex matrix in aqueous medium, wherein the absorption maximum is at a wavelength between 530 nm and 580 nm; adjusting the pH in the reacting step such that the absorption maximum of the substantially completely water soluble chromium-3 + -containing complex matrix is at the wavelength between 530 nm and 580 nm, and including the chromium-3 + -containing complex matrix into the composition in an amount effective to reduce blood glucose in a mammal in need thereof when the composition is orally administered to the mammal.