Patent ID: 6686371
Filing Date: 2004-02-03
Classification: A61P,C07C,C07D

Abstract:
A method of inducing an estrogenic or anti-estrogenic effect in a subject in need thereof, comprising:administering an effective amount of a compound according to Formula I wherein,one of Ra or Rb is 'Re and the other is H; Re and 'Re are OH, optionally independently etherified or esterified; X is N or â€”C(R1)â€”, wherein R1 is H, halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens; Y is N or â€”C (R2)â€”, with the proviso that X and Y are not both N, wherein R2 has the same meaning as defined for R1; Z is â€”C(R3, 'R3)â€” or â€”C(R4 ,'R4)â€”C(R5, 'R5)â€”, wherein R3, 'R3, R4, 'R4, R5, and 'R5, independently are H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens.