Patent ID: 6566520
Filing Date: 2003-05-20
Classification: C07C,C07D,C12N

Abstract:
A method for synthesizing a library of quinolone compounds of the formula: wherein R1 is H or F; which comprises:Step (a) reacting a building block containing tetrabenzo [a, c, g, i] fluorene group (Tbf-A) of the formula: with a building block B of the formula NH2R2 to form Tbf-A-B;Step (b) purifying the intermediate compound (Tbf-A-B), by adsorption on charcoal; Step (c) removing the intermediate compound (Tbf-A-B), from the charcoal with toluene; Step (d) repeating steps (a)-(c) using a number of building blocks to synthesize said library of compounds containing THF groups; and Step (e) removing the Tbf groups from the compounds by adsorption on charcoal and subsequently adding a cleaving reagent in a solvent to form said library of compounds.