Patent ID: 6187924
Filing Date: 2001-02-13
Classification: C07C,C07D

Abstract:
A compound represented by formula (I): ##STR3##whereinm is 0-2;X is S(O).sub.1-2 ;Y is NHOH;R.sup.1 is H or a group (substituted or unsubstituted with R.sup.7) selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, heterocycloalkyl, C.sub.1-6 alkyl-heterocycloalkyl, cycloalkyl, and C.sub.1-6 alkyl-cycloalkyl, and R.sup.2 is H or C.sub.1-6 alkyl;or CR.sup.1 R.sup.2 is a cycloalkyl or heterocycloalkyl ring substituted or unsubstituted with R.sup.7 or a group (substituted or unsubstituted with R.sup.7) selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, and C.sub.1-6 alkyl-heteroaryl;each B is the same or different and is selected from the group consisting of H, C.sub.1-6 alkyl-aryl, C.sub.1-6 alkyl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, cycloalkenyl, heterocycloalkenyl, C.sub.1-6 alkyl-heteroaryl, heterocycloalkyl, C.sub.1-6 alkyl-heterocycloalkyl, aryl, and heteroaryl, any of which groups is substituted or unsubstituted by a substituent selected from the group consisting of R.sup.3, C.sub.1-6 alkyl-R.sup.3, C.sub.2-6 alkenyl-R.sup.3, aryl (substituted or unsubstituted with R.sup.3), aryl-C.sub.1-6 alkyl-R.sup.3, C.sub.1-6 alkyl-aryl (substituted or unsubstituted with R.sup.3), C.sub.1-6 alkyl-heteroaryl (substituted or unsubstituted with R.sup.3), aryl-C.sub.2-6, alkenyl-R.sup.5, heteroaryl (substituted or unsubstituted with R.sup.3), heteroaryl-C.sub.1-6 alkyl-R.sup.3, cycloalkyl (substituted or unsubstituted with R.sup.3), and heterocycloalkyl (substituted or unsubstituted with R.sup.3), provided that NB.sub.2 is not NH.sub.2,or B--N--B is a heterocycloalkyl ring substituted with .dbd.O or .dbd.NOR.sup.4,or, when neither R.sup.1 nor R.sup.2 is H, B--N--B is a heterocycloalkyl or heterocyclalkenyl ring substituted or unsubstituted by a substituent selected from the group consisting of R.sup.3, C.sub.1-6 alkyl-R.sup.3, C.sub.2-6 alkenyl-R.sup.3, aryl (substituted or unsubstituted with R.sup.3), aryl-C.sub.1-6 alkyl-R.sup.3, C.sub.1-6 alkyl-aryl (substituted or unsubstituted with R.sup.3), C.sub.1-6 alkyl-heteroaryl (substituted or unsubstituted with R.sup.3), aryl-C.sub.2-6 alkenyl-R.sup.5, heteroaryl (substituted or unsubstituted with R.sup.3), heteroaryl-C.sub.1-6 alkyl-R.sup.3, cycloalkyl (substituted or unsubstituted with R.sup.3), and heterocycloalkyl (substituted or unsubstituted with R.sup.3);R.sup.3 is selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl-R.sup.5, halogen, CN, NO.sub.2, N(R.sup.4).sub.2, OR.sup.4, C(.dbd.NOR.sup.6)R.sup.4, CON(R.sup.4).sub.2, COR.sup.4, CO.sub.2 R.sup.8, NR.sup.4 R.sup.5, S(O).sub.0-2 R.sup.6, and SO.sub.2 N(R.sup.4).sub.2 ;R.sup.4 is selected from the group consisting of H, C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, heterocycloalkyl, and C.sub.1-6 alkyl-heterocycloalkyl, wherein said group is substituted or unsubstituted with a substituent selected from the group consisting of R.sup.6, COR.sup.6, SO.sub.0-2 R.sup.6, CO.sub.2 R.sup.6, OR.sup.6, CONR.sup.8 R.sup.6, NR.sup.8 R.sup.6, halogen, CN, SO.sub.2 NR.sup.8 R.sup.6, and NO.sub.2, and for each case of N(R.sup.4).sub.2 the R.sup.4 groups are the same or different or N(R.sup.4).sub.2 is heterocycloalkyl substituted or unsubstituted with a substituent selected from the group consisting of R.sup.6, COR.sup.6, SO.sub.2-2 R.sup.6, CO.sub.2 R.sup.6, OR.sup.6, CONR.sup.8 R.sup.6, NR.sup.8 R.sup.6, halogen, CN, SO.sub.2 NR.sup.8 R.sup.6, and NO.sub.2 ;R.sup.5 is selected from the group consisting of COR.sup.4, CON(R.sup.4).sub.2, CO.sub.2 R.sup.6, and SO.sub.2 R.sup.6 ;R.sup.6 is selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, and C.sub.1-6 alkyl-heteroaryl;R.sup.7 is selected from the group consisting of OR.sup.4, COR.sup.4, CO.sub.2 R.sup.8, CON(R.sup.4).sub.2, NR.sup.4 R.sup.5, S(O).sub.0-2 R.sup.6, SO.sub.2 N(R.sup.4).sub.2, halogen, CN, and cycloimidyl (substituted or unsubstituted with R.sup.8); andR.sup.8 is H or C.sub.1-6 alkyl;or the salts, solvates, hydrates, N-oxides, protected amino, protected carboxy, or protected hydroxamic acid derivatives thereof; andwherein provided that, when R.sup.7 is CON(R.sup.4).sub.2, R.sup.4 is not substituted with CONR.sup.6 R.sup.8.