Patent ID: 8697915
Filing Date: 2014-04-15
Classification: C07C,C09D

Abstract:
1. A process for the production of a diamino polyol compound having the formula: wherein each of the two amino (—NH 2 ) groups is bonded to a tertiary atom, R and R 3 are the same as each other and are each a, alkyl, aryl, or —CH 2 OH; R 1 and R 4 are the same as each other and are each, alkyl, aryl, or —CH 2 OH; alternatively, R and R 1 may be linked together to form a cycloalkyl; R 2 is independently alkyl, or phenyl; and alternatively, R 3 and R 4 may be linked together to form a cycloalkyl, said process comprising: (A)(i) reacting (1) a primary nitroalkane and (2) an α, β-unstaturated aldehyde, at a molar ratio of 2:1, and in the presence of an organic catalyst, and under conditions in which Michael addition and nitro-aldol (Henry) reaction, between the (1) primary nitroalkane and the (2) α,β-unsaturated aldehyde, occur sequentially, Michael reaction first, to form a dinitro alcohol; (A)(ii) further reacting the resulting dinitro alcohol with (3) an aldehyde to form a dinitro poly-alcohol compound; and (B) reducing the dinitro poly-alcohol compound of step (A)(ii) to the corresponding diamino polyol under hydrogenation conditions, in the presence of a catalyst.