Patent ID: 8420121
Filing Date: 2013-04-16
Classification: A61K,A61P

Abstract:
1. A drug delivery vehicle, comprising a first hydrogel comprising an opioid antagonist, wherein release of the opioid antagonist from the first hydrogel is stimulated by an increase in the concentration of CO a second hydrogel comprising an opioid, wherein release of the opioid from the second hydrogel is substantially CO wherein the second hydrogel comprises 25 to 50 mol % of the aminoalkyl (meth)acrylate of Formula 9 or an acid salt thereof, wherein G is oxygen or NR′ where R′ is hydrogen or C 40 to 70 mol % of an acetal (meth)acrylate of Formula 5 wherein R is hydrogen or methyl, and each R and 1 to 5 mol % of a crosslinker of Formula 6 wherein each R is independently hydrogen or methyl, n is 1 to 4, and R