Patent ID: 6410324
Filing Date: 2002-06-25
Classification: A61K,C12N,Y02P

Abstract:
A compound 8 to 30 nucleobases in length targeted to nucleobases 198 through 1472 of a coding region, or nucleobases 1512 through 3671 of a 3â€²-untranslated region of a nucleic acid molecule encoding a human Tumor Necrosis Factor Receptor 2 (SEQ ID NO: 3), or nucleobases 4477 through 8921 of an intron region encoding human Tumor Necrosis Factor Receptor 2 (SEQ ID NO: 17), or nucleobases 70-1164 of a coding region or nucleobases 1726-3751 of a 3â€²-untranslated region of a nucleic acid molecule encoding a mouse Tumor Necrosis Factor Receptor 2 (SEQ ID NO: 10), or nucleobases 698-743 of an intron region of a nucleic acid molecule encoding murine Tumor Necrosis Factor Receptor 2 (SEQ ID NO:98), wherein said compound specifically hybridizes with one or said regions and inhibits the expression of Tumor Necrosis Factor Receptor 2.