Patent ID: 7629493
Filing Date: 2009-12-08
Classification: C07C,C07D

Abstract:
1. A process for the crystallisation of a compound of formula I or an acid-addition salt thereof, in which R R R Het a saturated, unsaturated or aromatic, mono- or bicyclic, heterocyclic or linear or branched organic radical containing one or more hetero atoms which is unsubstituted or mono- or polysubstituted by A, COAr, COHet and/or Hal, Ar a phenyl radical which is unsubstituted or mono- or polysubstituted by A and/or Hal, OH, OA, COOH, COOA, CONH A straight-chain or branched alkyl or hydroxyalkyl having 1 to 10 C atoms, alkenyl or alkoxyalkyl having 2 to 10 C atoms, and Hal F, Cl, Br, I comprising dissolving the respective compound of formula I, optionally with impurities, at a given dissolution temperature in water which is virtually saturated with at least one water-immiscible solvent and optionally comprises one or more water-miscible solvents, and allowing the compound of formula I to crystallise at a temperature that is lower then said dissolution temperature, and wherein the water-immiscible solvent is an alkyl alkanoate or an aromatic solvent.