Patent ID: 6228987
Filing Date: 2001-05-08
Classification: A61K,A61P,C07K,C12N

Abstract:
A peptide immunogen represented by the formula:(A).sub.n -(Target antigenic site)-(B).sub.o -(Th).sub.m -Xor(A).sub.n -(B).sub.o -(Th).sub.m -(B).sub.o -(Target antigenic site)-Xor(A).sub.n -(Th).sub.m -(B).sub.o -(Target antigenic site)-Xor(Target antigenic site)-(B).sub.o -(Th).sub.m -(A).sub.n -X(Th).sub.m -(B).sub.o -(Target antigenic site)-(A).sub.n -Xwherein:A is an amino acid or SEQ ID NO:78, an immunostimulatory sequence, where n is more than one, the individual A's may be the same or different;B is selected from the group consisting of amino acids, --HCH(X)CH.sub.2 SCH.sub.2 CO--, --NHCH(X)CH.sub.2 SCH.sub.2 CO(.epsilon.-N)Lys-, --NHCH(X)CH.sub.2 S-succinimidyl(.epsilon.-N)Lys-, and --NHCH(X)CH.sub.2 S-(succinimidyl)-;Th is an artificial helper T cell epitope selected from the group consisting of SEQ ID NOS:31-35;""Target antigenic site"" is LHRH or a homolog thereof from another mammalian species;X is an .alpha.-COOH or --CONH.sub.2 of the terminal amino acid;n is from 0 to about 10;m is from 1 to about 4; ando is from 0 to about 10.