Patent ID: 8492315
Filing Date: 2013-07-23
Classification: G01N

Abstract:
1. A method of forming one or more metallic areas on a substrate for biological-testing, comprising the steps of: providing a photosensitive glass-ceramic substrate comprising a photosensitive glass-ceramic substrate and one or more metal containing compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals with a range of diameters that are less than about 300 nanometers and are spaced an average distance of at least one-half the midpoint of the diameter range apart; activating at least a portion of the photosensitive glass-ceramic substrate to form a pattern; heating the photosensitive glass-ceramic substrate to a temperature near a glass transformation temperature of the photosensitive glass-ceramic substrate to form one or more congregated metal nanoparticles in the photosensitive glass-ceramic substrate; baking the photosensitive glass-ceramic substrate to convert the one or more congregated metal nanoparticles into one or more metallic biological-binding areas; and etching the photosensitive glass-ceramic substrate to expose the one or more metallic biological-binding areas with an enhanced adherence to biological molecules.