Patent ID: 7514534
Filing Date: 2009-04-07
Classification: A61K,A61P,C07K

Abstract:
1. An isolated protein which binds to matrix metalloproteinase 26 (MMP-26), said protein comprising a heavy chain immunoglobulin variable domain (HC) sequence and a light chain immunoglobulin variable domain (LC) sequence, wherein (a) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:4 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:2; (b) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:8 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:6; (c) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:12 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:10; (d) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:16 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:14; (e) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:52 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:50; (f) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:104 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:102; (g) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:132 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:130; (h) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:148 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:146; (i) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:164 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:162; or (j) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:180 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:178.