Patent ID: 6376514
Filing Date: 2002-04-23
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having the structure: or an optical isomer, diastereomer, enantiomer, pharmaceutically-acceptable salt, amide, ester or biohydrolyzable imide susceptible to being cleaved in vivo by a mammalian subject to yield the compound of the claim thereof, wherein:(a) A1 is a group having the structure: â€ƒwherein: (i) each R1 is independently selected from the group consisting of a hydrogen atom, a hydroxyl group, a hydrocarbon group, a substituted hydrocarbon group, a carbocyclic group, a substituted carbocyclic group, an aromatic group, and a substituted aromatic group; (ii) x is from 0 to about 10; (iii) R2 is selected from the group consisting of a hydrocarbon group, a substituted hydrocarbon group, a carbocyclic group, a substituted carbocyclic group, an aromatic group, and a substituted aromatic group; (iv) D1 and D2 are each independently selected from the group consisting of â€”C(O)â€” and â€”NR3â€”; with the proviso that wherein when D1 is â€”NR3â€” then D2 is â€”C(O)â€”, and wherein when D2 is â€”NR3â€” then D1 is â€”C(O)â€”; and (v) R3 is selected from the group consisting of a hydrogen atom and R2; and (b) A3 has the structure: â€ƒwherein: (i) each R1 is independently selected from the group consisting of a hydrogen atom, a hydroxyl group, a hydrocarbon group, a substituted hydrocarbon group, a carbocyclic group, a substituted carbocyclic group, an aromatic group, and a substituted aromatic group; (ii) t is from 0 to about 6; (iii) D4 is selected from the group consisting of â€”C(O)â€” and â€”CH(R1)â€”, and (iv) D5 is selected from the group consisting of â€”NHR6 and â€”OR6, wherein R6 is a quinolyl group; wherein each substituted group is independently substituted with a substituent selected from the group consisting of alkyl, alkoxy, and aromatic.