Patent ID: 7825099
Filing Date: 2010-11-02
Classification: A61K,A61P

Abstract:
1. A method for reducing ototoxin-induced hearing loss in an ear of a subject to be treated with an ototoxin which comprises topically applying to the canal of the subject's ear a liquid composition comprising a siRNA oligoribonucleotide in an amount effective to inhibit expression of a p53 gene in the cochlea of the subject's ear to reduce ototoxin-induced hearing loss in the subject's ear, wherein the siRNA comprises (i) a sense strand and (ii) an antisense strand that comprises the sequence set forth in SEQ ID NO: 48, wherein each strand is 19-23nucleotides in length, and wherein the siRNA may be modified in one or more sugar residues, one or more linkages between nucleotides, and/or one or more bases.