Patent ID: 7223778
Filing Date: 2007-05-29
Classification: A61P,C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar is selected from the group consisting of phenyl or naphthyl, each of which is substituted with up to 5 R R is oxygen or absent; R R R R X is independently selected at each occurrence from the group consisting of —CH Y and Z are independently selected at each occurrence from: 3- to 7-membered carbocyclic or heterocyclic groups, which are saturated, partially unsaturated, or aromatic, which may be further substituteted with one or more substituents independently selected from halogen, oxo, hydroxy, amino, cyano, C R R R straight, branched, and cyclic alkyl groups, and (cycloalkyl)alkyl groups, having 1 to 8 carbon atoms, and containing zero or one double or triple bonds, each of which 1 to 8 carbon atoms may be further substituted with one or more substituent(s) independently selected from oxo, hydroxy, halogen, cyano, amino, C R n is independently selected at each occurrence from 0, 1, and 2; with the proviso that not all of R