Patent ID: 7349080
Filing Date: 2008-03-25
Classification: B82Y,G01N

Abstract:
1. A method for evaluating interactions between an analyte of interest and a capture molecule, said method comprising: contacting a liquid raw sample with a sensing surface of an evanescent field sensor, wherein the liquid raw sample comprises the analyte of interest, and the sensing surface is coated with the capture molecule; and detecting a change in refractive index at the sensing surface, wherein the change in the refractive index indicates whether the analyte of interest interacts with the capture molecule, wherein the liquid raw sample is selected from the group consisting of a lysate, a supernatant of cultured cells, a bodily fluid, and a tissue extract, and the analyte is selected from the group consisting of a recombinant protein expressed by the cultured cells, a pathogen marker, an antibody specific to the pathogen marker, and a cancer cell marker.