Patent ID: 9161965
Filing Date: 2015-10-20
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating an episode of epilepsy comprising administering an inhibitor of PSD-95 which inhibits binding of NR2B subunit of an NMDA receptor to a PDZ domain of PSD-95 in an effective regime for treatment of the episode, wherein in the effective regime for treatment of the episode the inhibitor is administered up to 4 hours after termination of an episode of epilepsy without administering the inhibitor before or during the episode wherein the inhibitor is Tat-NR2B9c (SEQ ID NO:10). F-Tat-NR2B9c (SEQ ID NO:46) or a chimeric peptide having the amino acid sequence of SEQ ID NO:8.