Patent ID: 6512135
Filing Date: 2003-01-28
Classification: C07C,C07D

Abstract:
A method of making a compound of formula 3 comprising:adding under sufficient conditions a suitable protecting group R1 and a leaving group X to a compound of formula 1 â€ƒwherein R1 is alkyl; cycloalkyl; heterocycloalkyl; aryl; heteroaryl; or a group of formula 8 â€ƒwherein R2 is an alkyl group, a cycloalkyl group, a heterocycloalkyl group, or Oâ€”R6, wherein R6 is an alkyl group, an aralkyl group, or an aryl group; or further wherein R1 is a group of formula 9 â€ƒwherein each R3 is independently an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; or further wherein R1 is a group of formula 10 â€ƒwherein R4 and each R5 independently are an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; and X is OH; OR7, wherein R7 is alkyl or aryl; halogen; pseudohalogen; OSO2R8, wherein R8 is alkyl or aryl; heteroaryl bonded through the heteroatom; or N-hydroxyheterocyclic bonded through the oxygen, with the proviso that when R1 is â€”CH3, X cannot be â€”OCH3 or â€”OH, and when R1 is CH3C(O)â€”, X cannot be â€”OH; to form the compound of formula 3.