Patent ID: 7704999
Filing Date: 2010-04-27
Classification: A61P,C07D,C07F

Abstract:
1. A method of treating a cardiovascular disorder selected from the group consisting of neuronal hypertonia, stable and unstable angina, peripheral and cardial vascularpathies, arrhythmiae, myocardial infarction, transistory and ischaemic attacks, angina pectoris, and resenoses, said method comprising administering to a subject in need thereof an effective amount of a compound of the general formula (I) in which R R R represents a straight-chain or branched alkyl chain having up to 10 carbon atoms which is optionally interrupted by an oxygen atom and which is optionally mono- or polysubstituted by identical or different substituents selected from the group consisting of trifluoromethyl, trifluoromethoxy, hydroxyl, halogen, carboxyl, benzyloxycarbonyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms and/or by radicals of the formulae —SO in which a and b are identical or different and each represents a number 0 or 1, A represents a radical CO or SO R c represents a number 0 or 1, R or R R R R and/or R and/or R or represents cycloalkyl having 3 to 8 carbon atoms, aryl having 6 to 10 carbon atoms or represents a 5- to 7-membered partially unsaturated, saturated or unsaturated, optionally benzo-fused heterocycle which may contain up to 4 heteroatoms from the group consisting of S, N and O, or a radical of the formula —NR in which R and where cycloalkyl, aryl and/or the heterocycle are optionally mono- or polysubstituted by identical or different substituents selected from the group consisting of halogen, triazolyl, trifluoromethyl, trifluoromethoxy, carboxyl, straight-chain or branched acyl or alkoxycarbonyl having in each case up to 6 carbon atoms, nitro and/or by groups of the formulae —SO in which e represents a number 0 or 1, R R R and/or cycloalkyl, aryl and/or the heterocycle are optionally substituted by straight-chain or branched alkyl having up to 6 carbon atoms which is optionally substituted by hydroxyl, carboxyl, by a 5- to 7-membered heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, or by groups of the formula —SO in which R R R R or R or R or E represents radicals of the formulae and the heterocycle listed under R in which R R j represents a number 0 or 1, and R may be substituted by hydroxyl or by straight-chain or branched alkyl or alkoxy having in each case up to 6carbon atoms, or R R and their salts, hydrates, N-oxides and isomeric forms.