Patent ID: 6812240
Filing Date: 2004-11-02
Classification: A61P,C07D,C07F

Abstract:
A method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective amount of a compound represented by the general formula I; wherein a wavy line represents either the &agr; configuration or the &bgr; configuration and a dotted line represents the presence or absence of a double bond;A represents a single bond or a cis double (alkene) bond or a triple (alkyne) bond; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R, SONR2 or n is 0 or an integer of from 1 to 4; x and y are 0 or 1, provided however when x is 1, y is 0 and when x is 0, y is 1; Z is S or O; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl or alkenyl; Ar is selected from the group consisting of aryl or heteroaryl radicals, having from 4 to 10 carbon atoms, or substituted derivatives of said aryl or heteroaryl radicals, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR and R3 is R, OR, CH2OR or COR.