Patent ID: 8338449
Filing Date: 2012-12-25
Classification: A61P,C07D

Abstract:
1. A compound of the structure: or a pharmaceutically acceptable salt or crystal form, wherein: A is R R R R R R R n, p, q, r, and s are independently 0, 1, 2, 3, 4, 5 or 6; provided that wherein the compound, or a pharmaceutically acceptable salt thereof, is selected from the group consisting of 3-tert-butyl-4-(3-fluorophenyl)-6-methoxy-2-methylisoquinolin-1(2H)-one, 3-tert-butyl-4-(4-fluorophenyl)-6-methoxy-2-methylisoquinolin-1(2H)-one, 6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one, 4-(4-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one, (1E)-11-(3-fluorophenyl)-9-methoxy-3,4-dihydro-2H-pyrido[1,2-b]isoquinoline-1,6-dione 1-oxime, 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 2,3-dimethyl-4-phenylisoquinolin-1(2H)-one, 3-tert-butyl-2-ethyl-6-methoxy-4-phenylisoquinolin-1(2H)-one, 3-tert-butyl-6-methoxy-4-phenylisoquinolin-1(2H)-one, 2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one, 6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one, 6-methoxy-2-(2-methoxyethyl)-3-methyl-4-phenylisoquinolin-1(2H)-one, 2-(2-aminoethyl)-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one, 2-(3-aminopropyl)-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one, 3-tert-butyl-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carbonitrile, 3-tert-butyl-8-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 3-tert-butyl-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide, 3-tert-butyl-2-methyl-4-phenyl-6-(4-phenylbutoxy)isoquinolin-1(2H)-one, 3-tert-butyl-2-methyl-4-phenyl-6-[(5-phenylpentyl)oxy]isoquinolin-1(2H)-one, (+/−)-11-(3-fluorophenyl)-1-hydroxy-9-methoxy-1,2,3,4-tetrahydro-6H-pyrido[1,2-b]isoquinolin-6-one, (1S)-11-(3-fluorophenyl)-1-hydroxy-9-methoxy-1,2,3,4-tetrahydro-6H-pyrido[1,2-b]isoquinolin-6-one, (1R)-11-(3-fluorophenyl)-1-hydroxy-9-methoxy-1,2,3,4-tetrahydro-6H-pyrido[1,2-b]isoquinolin-6-one, and 11-(3-fluorophenyl)-9-methoxy-1,2,3,4-tetrahydro-6H-pyrido[1,2-b]isoquinolin-6-one.