Patent ID: 9114072
Filing Date: 2015-08-25
Classification: A61K,A61P,B33Y

Abstract:
1. A process for preparing a pharmaceutical rapidly dispersing non-compressed solid matrix comprising one or more active ingredients and bound particles of bulk material, the process comprising: a) providing one or more layers of powdered bulk material comprising a mixture of a pharmaceutically acceptable compound, one or more active ingredients and a water soluble pharmaceutically acceptable binder; b) applying a first binding fluid, comprising a pharmaceutically acceptable solvent or a mixture of a pharmaceutically acceptable solvent and a water soluble pharmaceutically acceptable binder which is the same as or different than the binder in the powdered bulk material, to the one or more layers of bulk material using three-dimensional printing technique; and c) evaporating the solvent to provide a rapidly dispersing non-compressed solid matrix having a three-dimensional shape, wherein the solid matrix: 1) is able to maintain its three dimensional shape in the absence of moisture; 2) is able to exhibit hardness and friability characteristics adequate for storage and handling; and 3) is dispersed completely within a time period of less than about ninety seconds upon contact of said solid matrix with water in an environment of use.