Patent ID: 8183210
Filing Date: 2012-05-22
Classification: A61K,A61P,C07K

Abstract:
1. A reconstituted surfactant, comprising: (a) a lipid carrier; (b) at least one polypeptide represented by formula (Ib) (SEQ ID NO: 14): wherein: each X is independently an amino acid residue selected from the group consisting of I, L, and nL; B is an amino acid residue selected from the group consisting of K, W, F, Y, and Orn; each S is independently optionally substituted with an acyl group containing 12-22 carbon atoms linked to the side chain via an ester bond; Ω is an amino acid residue selected from the group consisting of M, M which is oxidized at the sulfur atom, I, L, and nL; a is an integer having a value of 1 to 8; b is an integer having a value of 1 to 19; and each p is independently 0 or 1, or at least one pharmaceutically acceptable salt thereof, or at least one blocked N- and/or C-terminus derivative thereof; and (c) at least one polypeptide represented by formula (II) (SEQ ID NO: 11): wherein: Δ is an amino acid residue selected from the group consisting of W and L; each Ω is independently an amino acid residue selected from the group consisting of M, I, L, and nL; Φ is an amino acid residue selected from the group consisting of R and T; and f is an integer having a value of 0 or 1, or at least one pharmaceutically acceptable salt thereof, or at least one blocked N- and/or C-terminus derivative thereof.