Patent ID: 6133272
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A method for treating a sexual dysfunction in a female in need thereof comprising administering to the female a therapeutically effective amount of a composition comprising a compound having the structure X and a pharmaceutically acceptable carrier, wherein the compound having structure X is: ##STR20## wherein a is an integer from 2 to 3; D is (i) --NO, (ii) --NO.sub.2, (iii) --CH(R.sub.d)--O--C(O)--Y--Z--(C(R.sub.e)(R.sub.f)).sub.p --T--Q, wherein R.sub.d is a hydrogen, a lower alkyl, a cycloalkyl, an aryl, an arylalkyl, or a heteroaryl; Y is oxygen, sulfur, CH.sub.2 or NR.sub.i, wherein R.sub.i is a hydrogen or a lower alkyl; R.sub.e and R.sub.f are each independently a hydrogen, a lower alkyl, a haloalkyl an alkoxy, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, an amino, an alkylamino, an amido, an alkylamido, a dialkylamino, a carboxylic acid, a carboxylic ester, a carboxamido or --T--Q, or R.sub.e and R.sub.f taken together are a carbonyl, a cycloalkyl a heterocyclic ring or a bridged cycloalkyl; p is an integer from 1 to 10; T is independently a covalent bond, oxygen, sulfur or NH; Z is a covalent bond, a lower alkyl, a haloalkyl, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, a heteroalkyl, an arylheterocyclic ring or (C(R.sub.e)(R.sub.f)).sub.p ; and Q is --NO or --NO.sub.2 ; (iv) --(O)--Y--Z--G--(C(R.sub.e)(R.sub.f)).sub.q --T--Q).sub.p, wherein G is a covalent bond, --T--(O)--, --C(O)--T-- or T, wherein q is an integer from 0 to 5, and Y, Z, R.sub.e, R.sub.f, p, T and Q are as defined above; or (v) --P--Z--(G--(C(R.sub.e)(R.sub.f)).sub.q --T--Q).sub.p, wherein P is a carbonyl, a phosphoryl or a silyl, and Z, G, p, q, T, Q, R.sub.e and R.sub.f are as defined above; andD.sub.1 is D or a hydrogen.