Patent ID: 6339073
Filing Date: 2002-01-15
Classification: A61K,A61P,C07H

Abstract:
A method of killing tumor cells or fungal or parasitic microorganisms which comprises contacting the tumor cells or the fungal or parasitic microorganisms with an amount of nicotinamide or a pyridine analog thereof that is linked to ADP-ribose or a structure-modified analog thereof selected from the group consisting of cyclic ADP-ribose, 2â€² and 3â€² deoxy ADP-ribose, such that, when NADase hydrolyzes said nicotinamide or said pyridine analog thereof free from said ADP-ribose or said structure-modified analog thereof, said ADP-ribose or said structure-modified analog thereof is selectively internalized into said tumor cells or said fungal or parasitic microorganisms in an amount effective to increase clonogenic toxicity of said tumor cells or said fungal or parasitic microorganisms.