Patent ID: 7473805
Filing Date: 2009-01-06
Classification: A61P,C07C,Y02P

Abstract:
1. A process for obtaining 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine of formula (I) wherein the asterisk indicates an asymmetric carbon atom, its enantiomers or mixtures thereof, or its pharmaceutically acceptable salts, comprising: (a) oxidizing the alcohol of formula (IV) wherein the asterisk has the previously indicated meaning and R is a hydroxyl protecting group, to give a compound of formula (II) wherein R and the asterisk have the previously indicated meanings; (b) reacting the compound of formula (II) with diisopropylamine in the presence of a reducing agent to give a compound of formula (III) wherein R and the asterisk have the previously indicated meanings; (c) removing the hydroxyl protecting group from the compound of formula (III) to obtain the compound of formula (I); and (d) if so desired, separating the desired (R) or (S) enantiomer, or the mixture of enantiomers, and/or converting the compound of formula (I) into a pharmaceutically acceptable salt thereof.