Patent ID: 6653320
Filing Date: 2003-11-25
Classification: A61K,A61P,C07D

Abstract:
An imidazopyridine derivative represented by formula (I) or salts thereof: wherein R1 represents â€”H, -a lower alkyl, -a lower alkenyl, -a lower alkynyl, -a cycloalkyl, -a cycloalkenyl, -a halogen, â€”NO2, â€”CN, -a halogenated lower alkyl, â€”OH, â€”O-a lower alkyl, â€”O-an aryl, â€”SH, â€”S-a lower alkyl, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOH, â€”COO-a lower alkyl, â€”CO-a lower alkyl, â€”CO-an aryl, -an aryl,-a lower alkylene-a aryl, â€”O-a lower alkylene-an aryl, â€”CONH2, â€”SO2NH2, a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group, â€”SO3H, â€”NH2, â€”NH-a lower alkyl or â€”N(a lower alkyl)2, T represents CR1a; U represents CR3; n represents an integer, 1, 2 or 3; in Y1 . . . Y2 . . . Y3, Y1 and Y3 are bonded with each other via 2 atoms and combined with the adjacent Y2 to form a B ring, wherein the B ring represents a 5-membered monocyclic heteroaryl ring having 1 to 4 hetero atoms selected from the group consisting of N, S, and O, whereas said B ring may be substituted by one to two R4s; X represents S, SO or SO2; â€œAâ€  represents a linkage, a lower alkylene, a lower alkenylene or a lower alkynylene; R2 represents -a lower alkyl which may have one or more substituents selected from Group D, -a lower alkenyl which may have one or more substituents selected from Group D, -a lower alkynyl which may have one or more substituents selected from Group D, -a cycloalkyl which may have one or more substituents selected from Group G, -a cycloalkenyl which may have one or more substituents selected from Group G, â€”N&boxH;O, -an aryl which may have one or more substituents selected from Group G, or -a heteroaryl which may have one or more substituents selected from Group G; wherein Group D consists of -a halogen, â€”NO2, â€”CN, â€”OH, â€”O-a lower alkyl, â€”O-a halogenated lower alkyl, â€”SH, â€”S-a lower alkyl, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOH, â€”COO-a lower alkyl, â€”CO-a lower alkyl, â€”CONH2, â€”NH2, â€”NH-a lower alkyl, â€”N(a lower alkyl)2, â€”(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), -an aryl, -a heteroaryl, -a cycloalkyl and -a cycloalkenyl; Group G consists of -a lower alkyl which may have 1Ëœ5 substituents which are selected from Group D, -a lower alkenyl which may have 1Ëœ5 substituents which are selected from Group D, -a lower alkynyl which may have 1Ëœ5 substituents which are selected from Group D, -a cycloalkyl which may have 1Ëœ5 substituents which are selected from Group E, -a cycloalkenyl which may have 1Ëœ5 substituents which are selected from Group E, -a halogen, â€”NO2, â€”CN, -a halogenated lower alkyl, â€”O-a halogenated lower alkyl, â€”OH, â€”O-a lower alkyl, â€”SH, â€”S-a lower alkyl, â€”SO2-a lower alkyl, â€”SO-a lower alkyl, â€”COOH, â€”COO-a lower alkyl, â€”CHO, â€”CO-a lower alkyl, â€”SO3H, â€”Ar1, â€”Oâ€”Ar1, â€”Sâ€”Ar1, â€”COâ€”Ar1, â€”SO2â€”Ar1, â€”SOâ€”Ar1, -a lower alkylene-Ar1, â€”O-a lower alkylene-Ar1, â€”CONH2, â€”CONH-a lower alkyl, â€”CON(a lower alkyl)2, â€”SO2NH2, â€”SO2NH-a lower alkyl, â€”SO2N(a lower alkyl)2, â€”CO-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”SO2-a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), -(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”NH2, â€”NH-a lower alkyl, â€”N(a lower alkyl)2, â€”NHCO-a lower alkyl, â€”NHCOâ€”Ar1, â€”NHSO2-a lower alkyl, â€”NHSO2â€”Ar1, -azido and â€”N&boxH;Nâ€”Ar1; wherein Group E consists of -a lower alkyl, -a lower alkenyl, -a lower alkynyl and the substituents in said Group D; and wherein Ar1 is an aryl or a heteroaryl which may have 1 to 5 substituents selected from Group E; R1a and R3, which may be the same or different, represent a group defined by R1; and R4 represents a group defined by R1, or an oxo group (&boxH;O).