Patent ID: 6156746
Filing Date: 2000-12-05
Classification: C07D

Abstract:
A compound of the formula ##STR18## or its enantiomer, diasteromer, or its pharmaceutically acceptable salt, prodrug of solvate thereof wherein:r, s and t are 0 or 1;p is 0, 1 or 2;X.sup.1 and X.sup.2 are each independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, akenyl, substituted alkenyl, alkynyl, substituted alkynyl, aralkyl, cycloalkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo or when X.sup.1 and X.sup.2 are taken together they represent an oxygen atom double bonded to the carbon atom of the ring;Y is selected from the group consisting of CHR.sup.9, or CR.sup.9 R.sup.10 ;Z is --CO--, --SO.sub.2 -- or Z is absent;R.sup.6, R.sup.7, R.sup.9, R.sup.10, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25 and R.sup.26, are selected from the group consisting of hydrogen, lower alkyl or substituted alkyl;R.sup.4, R.sup.5 are selected from the group consisting of hydrogen, halo, nitro, cyano and U-R.sup.11 ; R.sup.4 and R.sup.5 may join together to form a carbocyclic or heterocyclic ring;U is selected from the group consisting of sulfur, oxygen, NR.sup.12, CO, SO, SO.sub.2, CO.sub.2, NR.sup.13 CO.sub.2, NR.sup.14 CONR.sup.15, NR.sup.16 SO.sub.2, NR.sup.17 SO.sub.2 NR.sup.18, SO.sub.2 NR.sup.19, NR.sup.20 CO, CONR.sup.21, PO.sub.2 R.sup.22 and PO.sub.3 R.sup.23 or U is absent;R.sup.1, R.sup.2 and R.sup.11 are selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aralkyl, cycloalkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo;R.sup.8 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aralkyl, cycloalkyl, aryl, substituted aryl, heterocyclo excluding imidazole or substituted heterocyclo excluding imidazole;R, S and T are selected from the group consisting of CH.sub.2, CO and CH(CH.sub.2).sub.p Q wherein Q is NR.sup.24 R.sup.25 or OR.sup.26 ;and A, B, C and D are carbon, oxygen, sulfur or nitrogen;with the proviso that R.sup.11 may be hydrogen except when U is SO, SO.sub.2, NR.sup.13 CO.sub.2 or NR.sup.16 SO.sub.2.