Patent ID: 6444688
Filing Date: 2002-09-03
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is OH, Oâ€”C(O)â€”(C1-C6 alkyl), Oâ€”C(O)â€”O(C1-C6 alkyl), Oâ€”C(O)â€”Ar, or Oâ€”C(O)â€”Oâ€”Ar; R2 is H, OH, O(C1-C6 alkyl), Oâ€”C(O)â€”(C1-C6 alkyl), Oâ€”C(O)â€”O(C1-C6 alkyl), Oâ€”C(O)â€”Ar, Oâ€”C(O)â€”Oâ€”Ar, Oâ€”SO2â€”(C4-C6 alkyl), chloro, fluoro, or bromo; V is S, O, or CH2CH2; W is CHOH, C(O), or CH2; X is (CH2)n; R3 and R4 each, independently, are H, C1-C6 alkyl, C(O)â€”(C1-C6 alkyl), C(O)â€”NHâ€”(C1-C6 alkyl), C(O)â€”Ar, or together with the nitrogen to which they are attached form a 5- or 6-membered imide or cyclic amide; n is 1, 2, or 3; and Ar is optionally substituted phenyl; provided that at least one of R3 and R4 contain a carbonyl functional group.