Patent ID: 6451601
Filing Date: 2002-09-17
Classification: C07K,C12N

Abstract:
A fusion polypeptide, comprising:(i) a first part comprising a translocation moiety, said translocation moiety comprising a transport function, said translocation moiety selected from the group consisting of: (a) a polypeptide comprising a herpesviral VP22 protein; (b) a polypeptide comprising a human immunodeficiency virus (HIV) TAT protein; (c) a polypeptide comprising a homeodomain of an Antennapedia protein (Antp HD); (d) a polypeptide comprising an Arginine repeat (Arg repeat); and (e) a cationic polymer; and (ii) a second part comprising a polypeptide selected from the group consisting of: (a) a polypeptide having cell immortalization activity, (b) a polypeptide that synthesizes telomeric DNA at chromosomal ends, and (c) a polypeptide which is a transcriptional activator of telomerase activity resulting in synthesis of telomeric DNA at chromosomal ends.