Patent ID: 6558669
Filing Date: 2003-05-06
Classification: A61K,C07H,C07K,G01N

Abstract:
An aminopolycarboxylate-appended peptide useful for radioiodinating an antibody, comprising:(a) a peptide that comprises at least one D-tyrosine or tyramine, an amino terminus, a carboxy terminus formed from a D-lysine and no contiguous L-amino acids between the D-tyrosine or tyramine and the carboxy terminus; (b) an aminopolycarboxylate conjugated via one of its carboxylic acid groups to the peptide via an &egr;-amino group of the D-lysine to form an aminopolycarboxylate-appended peptide; and (c) a linker group for covalently binding said aminopoly-carboxylate-appended peptide to an antibody.