Patent ID: 6491939
Filing Date: 2002-12-10
Classification: A61K

Abstract:
A method for selectively increasing release of a predetermined endogenous compound comprising the steps of:selecting an in situ locus in the central nervous system which includes agonist receptors and heterologous receptors that are coupled to common G-proteins; and stereotaxically delivering to the in situ locus at least one biodegradable, non-spherical polymeric microstructure comprising an agonist and a pharmaceutically acceptable carrier, wherein the microstructure has a size and shape sufficient to prevent dispersion from the locus, and wherein the microstructure provides sustained release of the agonist via surface erosion to effectively upregulate G-proteins common to the agonist receptor and the heterologous receptor to potentiate the heterologous receptor in order to increase release of the endogenous compounds released by the heterologous receptor.