Patent ID: 6255285
Filing Date: 2001-07-03
Classification: A61K,C07K

Abstract:
A compound represented by formula (1), a hydrate thereof or a pharmaceutically acceptable salt thereof: ##STR131##wherein A is an amino acid residue or an N.alpha.-substituted amino acid residue, provided that A binds with --NR.sub.2 -- to form an amide;R.sub.1 is R.sub.6 --CO--, an optionally substituted straight-chained or branched alkyl group having 2-7 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 3-8 carbon atoms, or an optionally substituted straight-chained or branched alkynyl group having 3-8 carbon atoms;R.sub.2 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms;R.sub.3 is --CO--R.sub.7, an optionally substituted straight-chained or branched alkyl group having 1-5 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-5 carbon atoms or an optionally substituted straight-chained or branched alkynyl group having 2-5 carbon atoms;R.sub.4 is a straight-chained or branched alkyl group having 1-6 carbon atoms, a straight-chained or branches alkenyl group having 2-6 carbon atoms, a straight-chained or branched alkynyl group having 2-6 carbon atoms, or the formula (2): ##STR132##R.sub.5 is a hydrogen atom or --OR.sub.8 ;R.sub.6 is an optionally substituted straight-chained or branched alkyl group having 1-6 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-7 carbon atoms, an optionally substituted alkynyl group having 2-7 carbon atoms, a cycloalkyl group having 3-7 carbon atoms that may be fused to a benzene ring or a heterocyclic ring, an aromatic ring having 6-12 carbon atoms, and being optionally substituted with one or more substituents independently selected from the group consisting of a hydroxyl group, a methoxy group, a phenoxy group, a benzyloxy group,a tert-butyloxy group, an amino group, a methylamino group, a dimethylamino group, an ethylamino group, a carboxyl group, a methoxycarbonyl group and a phenyl group, an optionally substituted saturated or unsaturated heterocyclic ring having 3-12 carbon atoms, --N(R.sub.9)R.sub.10 or --OR.sub.11 ;R.sub.7 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-5 carbon atoms, a cycloalkyl group having 3-7 carbon atoms, --N(R.sub.12)R.sub.13 or --OR.sub.14 ;R.sub.8 is a hydrogen atom or a straight-chained alkyl group having 1-4 carbon atoms;R.sub.9 and R.sub.10, which may be the same or different, each represent a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-5 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, an optionally substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms that may be fused to a benzene ring or a heterocyclic ring, or an optionally substituted aromatic ring having 6-12 carbon atoms;R.sub.11 is an optionally substituted straight-chained or branched alkyl group having 1-5 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, an optionally substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms that may be fused to a benzene ring or a heterocyclic ring, or an optionally substituted aromatic ring having 6-12 carbon atoms;R.sub.12 and R.sub.13, which may be the same or different, each represent a hydrogen atom, a straight-chained or branched alkyl group having 1-4 carbon atoms or a cycloalkyl group having 3-7 carbon atoms;R.sub.14 is a hydrogen atom, a straight-chained or branched alkyl group having 1-6 carbon atoms, or a cycloalkyl group having 3-7 carbon atoms;R.sub.15 is a hydrogen atom or a methyl group;R.sub.16 and R.sub.17 are taken together and represent a cycloalkyl or cycloalkenyl group having 3-7 carbon atoms.