Patent ID: 7427636
Filing Date: 2008-09-23
Classification: A61K,C07D,C07F

Abstract:
1. A method for inhibiting IMPDH in vitro comprising contacting a sample in need of such treatment with a conjugate or a pharmaceutically acceptable salt or solvate thereof wherein the conjugate is a compound of formula: wherein: DRUG is a compound of formula 501: wherein: nn is 1, 2, or 3; A Y Y R wherein: R R R R R R R R R R W W W W M2 is 0, 1 or 2; M12a is 1,2,3,4,5,6,7,8,9,10,11 or 12; M12b is 0,1,2,3,4,5,6,7,8,9,10,11 or 12; M1a, M1c, and M1d are independently 0 or 1; and M12c is 0,1,2,3,4,5,6,7,8,9,10,11 or 12.