Patent ID: 6225342
Filing Date: 2001-05-01
Classification: A61K,A61P

Abstract:
A method of treating a skin disease involving hyperproliferation of dermis cells in a mammal which comprises administering to the mammal an effective, non-toxic amount of a compound of Formula (I) ##STR30##whereinR.sup.1 and R.sup.2 are independently selected from H, OH, and esters of OH with saturated or unsaturated straight-or branched chain C.sub.1 -C.sub.20 carboxyalkyl acids or carboxy aromatic acids;R.sup.3 is selected from OH, and esters of OH with saturated or unsaturated straight-or branched chain C.sub.1 -C.sub.20 carboxyalkyl acids or carboxy aromatic acids,R.sup.4 is selected from C.sub.6 -C.sub.12 saturated or unsaturated monocyclic or polycyclic aliphatic ring systems optionally substituted by C.sub.1 -C.sub.6 alkyl, H, OH,=CH.sub.2 or C.sub.1 -C.sub.4 alkyl carboxyloxy or R.sup.4 represents a C.sub.1 -C.sub.6 straight-or branched chain alkylene (alkalene) group substituted with (a system) a said optionally substituted saturated or unsaturated monocyclic or polycyclic aliphatic ring system;R.sup.5 is selected from --CH.sub.3, --CHO, --COOH, and --CH.sub.2 OH and esters of CH.sub.2 OH with saturated or unsaturated straight-or branched chain C.sub.1 -C.sub.20 carboxyalkyl acids or carboxy aromatic acids; and ethers of CH.sub.2 OH with straight or branched C.sub.1 -C.sub.20 alkyl chain alcohols and aromatic alcohols;R.sup.6 is selected from --OH, ##STR31##