Patent ID: 6096906
Filing Date: 2000-08-01
Classification: C07C,C07D,C07F

Abstract:
A process of preparing a compound of the formula ##STR49## or the enantiomer of said compound, wherein in said compound of formula X the R.sup.3 -substituted benzoic acid moiety is attached at carbon 6 or 7 of the chroman ring;R.sup.1 is --(CH.sub.2).sub.q CHR.sup.5 R.sup.6 wherein q is 0 to 4;each R.sup.2 and R.sup.3 is independently selected from the group consisting of H, fluoro, chloro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, phenylsulfinyl, phenylsulfonyl, and --S(O).sub.n (C.sub.1 -C.sub.6 alkyl) wherein n is 0 to 2, and wherein said alkyl group, the alkyl moiety of said alkoxy and --S(O).sub.n (C.sub.1 -C.sub.6 alkyl) groups, and the phenyl moiety of said phenylsulfinyl and phenylsulfonyl groups are optionally substituted by 1 to 3 fluoro groups;R.sup.5 is H, C.sub.1 -C.sub.6 alkyl, or phenyl substituted by R.sup.2 :R.sup.6 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.6 -C.sub.10 aryl, or 5-10 membered heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted by 1 or 2 substituents independently selected from phenyl, R.sup.2, and phenyl substituted by 1 or 2 R.sup.2 ;which comprises treating a compound of the formula ##STR50## or the enantiomer of said compound of formula IX in the preparation of the enantiomer of said compound of formula X, wherein R.sup.1, R.sup.2, and R.sup.3 are as defined above, R.sup.4 is C.sub.1 -C.sub.6 alkyl, and the benzoate moiety is attached to position 6 or 7 of the chroman ring, with a base.