Patent ID: 9045467
Filing Date: 2015-06-02
Classification: A61P,C07D

Abstract:
1. A method for treating a FAAH-mediated disease selected from the group consisting of osteoarthritis and pain, in a warm-blooded animal selected from the group consisting of a mouse, a rat, a horse, cattle, a sheep, a dog, and a cat, comprising administering to the warm-blooded animal an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof wherein: X is S or SO; n is 0, 1 or 2; R (1) aryl, and (2) HET 1 , wherein R wherein choices (p) and (q) are each optionally mono or di-substituted with substituents selected from with the proviso that the substituent on choice (q) is other than oxo or ═S, wherein R R R (1) aryl, (2) HET 3 , (3) —CH 2 -aryl, (4) —CH 2 -HET 3 , and (5) —C 3-6 cycloalkyl, wherein R R (1) HET 5 , and (2) C 3-6 cycloalkyl, wherein R