Patent ID: 6406894
Filing Date: 2002-06-18
Classification: A61K,C07H,C12P

Abstract:
A process for preparing a carbohydrate-containing polymer that is physiologically degradable in vivo in a mammal, wherein said carbohydrate-containing polymer comprises a non-naturally occurring hydrophilic, biodegradable polymer unit, a disaccharide or oligosaccharide unit, and a bifunctional spacer linking said disaccharide or oligosaccharide units to said polymer unit, comprising the steps of:(a) covalently linking a monosaccharide or oligosaccharide unit to a spacer to form a monosaccharide or oligosaccharide-spacer complex wherein said spacer has the formula (mono- or oligosaccharide)â€”Oâ€”[Q1â€”(CH2)pâ€”Q2]r-(polymer), wherein Q1 is â€”CH2or â€”COâ€”, Q2 is â€”NH or â€”COâ€”NHâ€”, p is an integer from 1 to 6, and r is 1 or 2; (b) covalently linking said monosaccharide or oligosaccharide-spacer complex to a non-naturally occurring hydrophilic, biodegradable polymer unit to form an acceptor unit; and (c) coupling a monosaccharide donor unit to said acceptor unit by enzymatic glycosylation.