Patent ID: 6465613
Filing Date: 2002-10-15
Classification: A61K,C07K

Abstract:
A compound comprising a somatostatin analog of the formula:W-X-(A-B)n-somatostatin peptide wherein:A is D-tyrosine, L-tyrosine, D-3-iodotyrosine, L-3-iodotyrosine, D-3,5-diiodotyrosine, L-3,5-diiodotyrosine, D-4-aminophenylalanine, or L-4-aminophenylalanine; B is D-lysine, L-lysine, D-arginine, L-arginine, D- or L-1,3-diaminopropionic acid, D- or L-1,4-diaminobutanoic acid, D-NH2â€”CH(Z)â€”CO2H, or L-NH2â€”CH(Z)â€”CO2H, wherein Z is (CH2)yNH2, wherein y is 1-10; X is A or B; W is NH2(CH2)tCO, wherein t=2-10,or is absent; n is 1-10; and each (A-B) may be the same as or different from each other (A-B).