Patent ID: 6894072
Filing Date: 2005-05-17
Classification: A61P,C07D

Abstract:
1. A compound, or enantiomer, stereoisomer, rotamer, tautomer, racemate or prodrug of said compound, or pharmaceutically acceptable salt or solvate of said compound, or pharmaceutically acceptable salt or solvate of said prodrug, said compound having the general structure shown in Formula I: wherein Z is selected from O, N, CH or CR; W may be present or absent, and if W is present, W is selected from C═O, C═S; Q may be present or absent, and when Q is present, Q is CH, N, P, (CH A is O, CH E is CH, N, CR, or a double bond towards A, L or G; G may be present or absent, and when G is present, G is (CH J is (CH L may be present or absent, and when L is present, L is CH, C(R), O, S or N(R); and when L is absent, then M may be present or absent; and if M is present with L being absent, then M is directly and independently linked to E, and J is directly and independently linked to E; M may be present or absent, and when M is present, M is O, N(R), S, S(O p is a number from 0 to 6; and R, R′, R wherein said alkyl, heteroalkyl, alkenyl, heteroalkenyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl moieties may be optionally substituted, with said term “substituted” referring to substitution with one or more moieties which can be the same or different, each being independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heterocyclic, halogen, hydroxy, thio, alkoxy, aryloxy, alkylthio, arylthio, amino, amido, ester, carboxylic acid, carbamate, urea, ketone, aldehyde, cyano, nitro, sulfonamido, sulfoxide, sulfone, sulfonyl urea, hydrazide, and hydroxamate; further wherein said unit N-C-G-E-L-J-N represents a five-membered cyclic ring structure with the proviso that when said unit N-C-G-E-L-J-N represents a five-membered cyclic ring structure, or when the bicyclic ring structure in Formula I comprising N, C, G, E, L, J, N, A, Q, and M represents a five-membered cyclic ring structure, then said five-membered cyclic ring structure lacks a carbonyl group as part of said five-membered cyclic ring.