Patent ID: 6716828
Filing Date: 2004-04-06
Classification: A61P,C07D,C07F

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt, hydrate, prodrug,wherein:m is zero or one; n is zero or one; p is one or two; Y is â€”N(R10)â€” or N; Z is O, or S; X is NR11, â€”Oâ€”, â€”Sâ€”, CR12R13 or a bond; â€”(SO2)m(NR16)nT(W)p is optionally substituted at R5 and R6; W is selected from â€”CN, â€”(N(R9)2) where the R9 substituents may be combined to form a heteroaryl or cycloalkyl optionally containing at least one hetero atom, â€”P(O)2â€” OR9, â€”P(O)(OR9)2, â€”S(O)2â€”R9, â€”S(O)3R9, â€”C(O)â€”R9â€”, â€”C(O)â€”N(R9)2, â€”S(O)2NR9, cycloalkyl optionally containing at least one heteroatom, and heteroaryl; R1, R2, R3, R4, R7 are independently: hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, halo, nitroso, sulfo, sulfonic acid or carboxy; R5, R6, R8, R12, R13, R14, and R15 are independently: hydrogen, lower alkyl, cycloalkyl optionally containing at least one heteroatom, lower alkenyl, lower alkoxy, aryl, heteroaryl, aralkyl, heteroaralkyl, alkaryl, alkheteroaryl, hydroxy, amino, nitro, halo, nitroso, sulfo, sulfonic acid or carboxy, with the proviso that R6 is not NH2, NO2, dimethylamine, pyrrole or imidazole; each R9 is independently: hydrogen, lower alkyl, cycloalkyl optionally containing at least one heteroatom, lower alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkaryl, heteroaralkyl, hydroxy, lower alcohol, alkoxy, amino, or carboxy; R10 and R11 independently: hydrogen, lower alkyl, lower alkenyl, aryl, aralkyl, alkaryl, halo, hydroxy, alkoxy, amino, or carboxy; each R16 is independently hydrogen or lower alkyl; and T is a divalent or trivalent organic radical independently selected from the group consisting of: lower alkylene, lower alkenylene, arylene, aralkylene, and alkarylene; wherein one, two or three of the hydrogen atoms of said divalent or trivalent organic radical can be substituted by a moiety selected from the group consisting of: lower (C1-C9 straight or branched chain) alkyl, cycloalkyl, lower (C2-C9 straight or branched chain) alkenyl, cycloalkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkaryl, alkheteroaryl, halo, trifluoromethyl, hydroxy, lower (C1-C4) alkoxy, amino, nitro, trifluoromethyl, alkenyloxy, phenoxy, and benzyloxy; wherein one, two or three carbon atoms in the divalent or trivalent organic radical can be replaced by a hetero-atom-containing-moiety selected from the group consisting of: phenoxy, phenoxymethyl, phenoxycarbonyl, benzyloxy, â€”Oâ€”, >C&boxH;O, â€”Sâ€”, â€”SO2â€”, â€”NR1SO2â€”, â€”SO2NR1â€”, â€”NR1â€”, and â€”PO2â€”; wherein any of the lower (C1-C9 straight or branched chain) alkyl, C3-C8 cycloalkyl optionally containing at least one heteroatom in place of a carbon atom, lower (C2-C9 straight or branched chain) alkenyl, aryl, heteroaryl, aralkyl, and alkaryl groups can be independently substituted with one, two or three substituents selected from the group consisting of: lower (C1-C9 straight or branched chain) alkyl, C3-C8 cycloalkyl optionally containing at least one heteroatom in place of a carbon atom, lower (C2-C9 straight or branched chain) alkenyl, cycloalkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkaryl, alkheteroaryl, halo, trifluoromethyl, hydroxy, lower (C1-C4) alkoxy, carboxy, carbonyl, lower alkyl ester, amino, nitro, trifluoromethyl, alkenyloxy, phenoxy, benzyloxy, wherein one, two, or three carbon atoms of any of the lower (C1-C9 straight or branched chain) alkyl, C3-C8 cycloalkyl optionally containing at least one heteroatom in place of a carbon atom, lower (C2-C9 straight or branched chain) alkenyl, aryl, heteroaryl, aralkyl, and alkaryl groups can be replaced by a hetero-atom-containing-moiety selected from the group consisting of: â€”Oâ€”, >C&boxH;O, â€”Sâ€”, â€”SO2â€”, â€”NR1SO2â€”, SO2NR1â€”, N, â€”NR1â€”, and â€”PO2â€”.