Patent ID: 6866851
Filing Date: 2005-03-15
Classification: A61P,C07K

Abstract:
1. A polypeptide which activates GFRα1-RET. but does not substantially activate GFRα2-RET or GFRα3-RET, wherein (a) said polypeptide comprises a persephin sequence essentially as set forth in SEQ ID NO: 1, and differing there from only by the presence of substitutions in region F2a (amino acids 60-67 of SEQ ID NO: 1) and substitutions in region F2c (amino acids 77-83 of SEQ ID NO: 1), (b) the substitutions in region F2a comprise from four to eight amino acids that are identical to region F2a of a GDNF family ligand, (c) the substitutions in region F2c comprise from seven to eight amino acids that are identical to region F2c of a GDNF family ligand, (d) the GDNF family ligand is a peptide of SEQ ID NO: 4.