Patent ID: 7282607
Filing Date: 2007-10-16
Classification: C07C

Abstract:
1. A process for preparing iopamidol comprising the steps of: mixing pentaacetyliopamidol with methanol and hydrochloric acid, heating said mixture, removing the methanol by distillation to form a residue, dissolving said residue in water to form a first solution, adding an acid scavenging resin to neutralize the hydrochloric acid of said first solution, filtering said first solution to remove said acid scavenging resin to form a second solution, passing said second solution through an amberlite resin column to form an eluant, concentrating said eluant to form an oil, heating said oil in a mixture comprising acetonitrile and ethanol to form iopamidol, collecting the iopamidol by filtration, washing the iopamidol with ethanol and drying the iopamidol.