Patent ID: 6608036
Filing Date: 2003-08-19
Classification: A61P,C07H,C12N,C12Q,C12Y

Abstract:
An oligonucleotide comprising a sequence of nucleoside subunits joined by N3â€²â†’P5â€² thiophosphoramidate inter-subunit linkages, wherein the oligonucleotide comprises a sequence selected from the group consisting of:GTTAGGGTTAG (SEQ ID NO:1); TAGGGTTAGACAA (SEQ ID NO:2); and CAGTTAGGGTTAG (SEQ ID NO:8) and wherein the N3â€²â†’P5â€² thiophosphoramidate inter-subunit linkages have the structure 3â€²-[â€”NHâ€”P(&boxH;O)(â€”SR)â€”Oâ€”]-5â€², wherein R is selected from the group consisting of hydrogen, alkyl, and aryl; and pharmaceutically acceptable salts thereof.