Patent ID: 8961925
Filing Date: 2015-02-24
Classification: A61J,G01N,Y02A

Abstract:
1. An in vitro method for estimation of portal blood flow in a subject, the method comprising: receiving a blood or serum sample consisting of a single sample collected from a subject suspected of having or developing, a hepatic disorder at a single, specific time point within 3 hours after oral administration of a stable isotope labeled distinguishable cholate compound to the subject, wherein no other distinguishable cholate compound is intravenously co-administered; measuring the concentration of the orally administered stable isotope labeled distinguishable cholate compound in the blood or serum sample, wherein the measuring step comprises quantifying the concentration of the distinguishable cholate compound in the sample by GC-MS or HPLC-MS; and comparing the concentration of the stable isotope labeled distinguishable cholate compound in the blood or serum sample to a distinguishable cholate compound concentration cutoff value or cutoffs of values established from a known patient population, wherein the concentration of stable isotope labeled distinguishable cholate compound in the sample compared to distinguishable cholate compound concentration cutoff value or cutoffs of values in the known patient population is an estimation of portal blood flow in the subject.