Patent ID: 7538123
Filing Date: 2009-05-26
Classification: A61P,C07D

Abstract:
1. A compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R 1 and R 2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form: (1) a 5- to 7-membered non-aromatic carbocyclic group, (2) a 5- to 7-membered non-aromatic heterocyclyl group, (3) a 6-membered aromatic carbocyclic group, or (4) a 5- or 6-membered aromatic heterocyclyl group, which may be substituted by 1 to 4 substituents selected from the following substituent group B1; R R Substituent group A1: (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) a hydroxyl group, (5) a nitro group, (6) a carboxyl group, (7) a C3-C8 cycloalkyl group, (8) a C2-C6 alkenyl group, (9) a C2-C6 alkynyl group, (10) a C1-C6 alkylthio group, (11) a C1-C6 alkoxycarbonyl group, (12) a C1-C6 alkylsulfonyl group, (13) a C1-C6 alkyl group (wherein said C1-C6 alkyl group may be substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a hydroxyl group, and a C1-C6 alkoxy group), (14) a C1-C6 alkoxy group (wherein said C1-C6 alkoxy group may be substituted by 1 to 3 halogen atoms), (15) an amino group (wherein said amino group may be substituted by a substituent selected from the group consisting of a C1-C6 alkyl group, a formyl group, a C1-C6 alkanoyl group, and a C1-C6 alkylsulfonyl group), and (16) a carbamoyl group (wherein said carbamoyl group may be substituted by one or two C1-C6 alkyl groups); Substituent group B1: (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) a hydroxyl group, (5) a nitro group, (6) an oxo group, (7) a carboxyl group, (8) a C3-C8 cycloalkyl group, (9) a C2-C6 alkenyl group, (10) a C2-C6 alkynyl group, (11) a C1-C6 alkylthio group, (12) a C1-C6 alkoxycarbonyl group, (13) a C1-C6 alkylsulfonyl group, (14) a C1-C6 alkyl group (wherein said C1-C6 alkyl group may be substituted by a halogen atom, a hydroxyl group, or a C1-C6 alkoxy group), (15) a C1-C6 alkoxy group (wherein said C1-C6 alkoxy group may be substituted by 1 to 3 halogen atoms), (16) an amino group (wherein said amino group may be substituted by a substituent selected from the group consisting of a C1-C6 alkyl group, a formyl group, a C1-C6 alkanoyl group, and a C1-C6 alkylsulfonyl group), (17) a carbamoyl group (wherein said carbamoyl group may be substituted by one or two C1-C6 alkyl groups), (18) a C1-C6 alkoxyimino group, (19) a C5-C6 cycloalkyl group formed by two C1-C3 alkyl groups attaching to the same carbon atom, and (20) a tetrahydropyranyl group formed by two C1-C3 alkyl group attaching to the same carbon atom, together with an oxygen atom and said carbon atom.