Patent ID: 8216495
Filing Date: 2012-07-10
Classification: A61K

Abstract:
1. A method of preparing a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), with a BCS Class II drug or a BCS Class IV drug, said method comprising a) dissolving the polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer) separately in a water/first alcohol mixture; and b) dissolving the BCS Class II drug or the BCS Class IV drug in a mixture of a second alcohol with a non alcoholic organic solvent in which the compound has an high solubility; and c) mixing both solutions to obtain a third solution with a total amount of solved solid of 0.01 g to 15 g per 100 ml; and d) spray drying the third solution.