Patent ID: 6734167
Filing Date: 2004-05-11
Classification: A61K,A61P

Abstract:
A method of reducing proliferation of cells comprising:(a) exposing said cells to a composition comprising at least one polypeptide comprising an amino acid sequence with the transport function of herpesviral VP22 protein, said polypeptide being coupled to at least one functionally active acid sequence, wherein the functionally active amino acid sequence is a protein or peptide which can regulate cell cycle progression, or functional analogue thereof; and (b) exposing said cells to at least one agent to further stimulate cell death, said agent selected from: drugs which can induce cell cycle arrest, cytotoxic chemotherapeutic drugs used as part of a treatment program of malignant disease, DNA damaging agents, agents which increase cellular sensitivity to DNA damage, and cytotoxic amounts of radiation.