Patent ID: 7189801
Filing Date: 2007-03-13
Classification: A61K,A61P,C07K

Abstract:
1. A peptide which competes with an endogenous p53 negative regulatory region for binding with a negative regulatory region of p53, said peptide containing at least four sequential amino acids from a negative regulatory region which maps to residues 361–383 of p53 (SEQ ID NO. 2), said peptide not being a subfragment of human p53, wherein said peptide activates, in p53 DNA binding assay, DNA binding of wild-type p53 or a p53 mutant, wherein said peptide contains residues of human p53 selected from the group consisting of 363–373 (SEQ ID NO. 4), 368–380 (SEQ ID NO. 5), 373–383 (SEQ ID NO.6), 371–383 (SEQ ID NO.7), 363–382 (SEQ ID NO.8), 367–386 (SEQ ID NO. 9),363–386 (SEQ ID NO. 10), 362–386 (SEQ ID NO.11), 360–386 (SEQ ID NO. 12), 363–370 (SEQ ID NO. 14), 368–373 (SEQ ID 15), 368–372 (SEQ ID NO. 16), 369–373 (SEQ ID NO.17), 370–375 (SEQ ID NO.18), and 370 –374 (SEQ ID NO.19).