Patent ID: 7767660
Filing Date: 2010-08-03
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I): wherein Ar is a moiety containing at least one aromatic ring and possesses 5-, 6-, 9- or 10-ring atoms optionally containing 1, 2 or 3 heteroatoms independently selected from N, O and S, which ring is optionally substituted by groups Q Q R or R R or R and wherein said C R R Q or Q A is C or A is a non-aromatic ring of 3 to 8 ring atoms where said ring may contain a double bond and/or may contain a O, S, SO, SO or A is a non-aromatic bicyclic moiety of 4 to 8 ring atoms, and A is optionally substituted by halogen, hydroxy, C D is N or CR R W is a bond, C═O, O, S(O) Y is a bond, C═O, O, —CR Z is a bond, C═O, O, S(O) and none, one or two of W, Y and Z are a bond; X is —CR R or one of R Het is a heteroaliphatic ring of 4 to 7 ring atoms, which ring may contain 1, 2 or 3 heteroatoms selected from N, O or S or a group S(O), S(O) 2 , NH or NC 1-4 alkyl; R or R R or R R B is —CR R or R M is C where R 23 is hydrogen or C 1-6 alkyl, or R 23 is linked to one of R 10 , R 14 and R 14a to form a ring of 4 to 10 atoms as hereinbefore described; where R 22 is halo, C 1-4 alkyl, (CH 2 ) 0-3 C 3-8 cycloalkyl, (CH 2 ) 0-3 aryl, (CH 2 ) 0-3 heteroaryl, (CH 2 ) 0-3 Het or oxo, or R 22 is linked to one of R 10 , R 14 and R 14a to form a ring of 4 to 10 atoms as hereinbefore described; or a pharmaceutically acceptable salt thereof.