Patent ID: 6375975
Filing Date: 2002-04-23
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition comprising:an effective amount of a macromolecular pharmaceutical agent; an alkali metal alkyl sulfate; at least three micelle-forming compounds selected from the group consisting of lecithin, hyaluronic acid, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, monoolein, monooleates, monolaurates, borage oil, evening primrose oil, menthol, trihydroxy oxo cholanyl glycine, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers, polidocanol alkyl ethers, chenodeoxycholate, deoxycholate, pharmaceutically acceptable salts thereof, analogues thereof, and mixtures or combinations thereof; and a suitable solvent; wherein the alkaline metal alkyl sulfate and each of the micelle-forming compounds are each present in a concentration of between about 1 and 20 wt./wt. % of the total composition, and the total concentration of the alkali metal alkyl sulfate and micelle-forming compounds together is less than 50 wt./wt. % of the total composition; wherein the macromolecular pharmaceutical agent is in micellar form.