Patent ID: 6440966
Filing Date: 2002-08-27
Classification: A61P,C07C

Abstract:
A compound of formula (I): whereinW is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB; R1 is H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, phenyl, (phenyl)C1-4 alkyl, (phenyl)C3-4 alkenyl, (phenyl)C3-4 alkynyl, (C3-8 cycloalkyl)C1-4 alkyl, (C3-8 cycloalkyl)C3-4 alkenyl, C3-8 cycloalkyl)C3-4 alkynyl, C3-8 heterocyclic radical, (C3-8 heterocyclic radical)C1-4 alkyl, (C3-8 heterocyclic radical)C3-4 alkenyl, (C3-8 heterocyclic radical)C3-4 alkynyl or (CH2)2-4NRARB; R2 is H, phenyl, C1-4 alkyl, C3-4 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, or (C3-8 cycloalkyl)-C1-4 alkyl; RA is H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, phenyl, (C3-8 cycloalkyl)C1-4 alkyl, (C3-8 cycloalkyl)C3-4 alkenyl, (C3-8 cycloalkyl)C3-4 alkynyl, C3-8 heterocyclic radical, (C3-8 heterocyclic radical)C1-4 alkyl, (aminosulfonyl)phenyl, [(aminosulfonyl)phenyl]C1-4 alkyl, (aminosulfonyl)C1-6 alkyl, (aminosulfonyl)C3-6 cycloalkyl, or [(aminosulfonyl)C3-6 cycloalkyl]C1-4 alkyl; RB is H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, or C6-8 aryl; R3 is H, F, Cl, Br, or NO2; R4 is H or F; R5 is H, methyl or Cl; R6 is H, C1-4 alkyl, hydroxyethyl, hydroxypropyl, (CH2)2-4(NRCRD), phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl or CH2Ar, where Ar is phenyl, 2-pyridyl, 3-pyridyl, or 4-pyridyl; R7 is H, C1-4 alkyl, hydroxyethyl, hydroxypropyl, (CH2)2-4(NRCRD), phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, or CH2Arâ€², where Arâ€² is phenyl, 2-pyridyl, 3-pyridyl, or 4-pyridyl; each of RC and RD is independently selected from H, C1-6 alkyl, C3-4 alkenyl, C3-4 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclic radical, and phenyl; NRCRD is also selected from the group consisting of morpholinyl, piperazinyl, pyrrolidinyl, and piperadinyl; wherein each hydrocarbon radical or heterocyclic radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, C1-4 alkyl, C3-6 cycloalkyl, C2-4 alkenyl, C2-4 alkynyl, phenyl, hydroxy, amino, (amino)sulfonyl, and NO2, wherein each substituent alkyl, cycloalkyl, alkenyl, alkynyl or phenyl is in turn optionally substituted with between 1 and 3 substituents independently selected from halo, C1-2 alkyl, hydroxy, amino, and NO2; or a pharmaceutically-acceptable salt or C1-6 ester thereof.