Patent ID: 8206723
Filing Date: 2012-06-26
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A modified Clostridial botulinum neurotoxin Type E having increased biological half-life consisting of one or more additional tyrosine-based motifs and one or more additional leucine-based motifs, wherein the tyrosine-based motif is SEQ ID NO: 24 or SEQ ID NO: 33, and wherein the leucine-based motif is SEQ ID NO: 15, SEQ ID NO: 18, SEQ ID NO: 19, or SEQ ID NO: 20, wherein the additional tyrosine-based motifs and additional leucine-based motifs increase biological half-life of the modified botulinum neurotoxin type E relative to an identical botulinum neurotoxin type E without the additional motifs.