Patent ID: 9102758
Filing Date: 2015-08-11
Classification: A61K,A61P,C07K

Abstract:
1. An insulin compound coupled to a modifying moiety having a formula: where, X, Y and Z are independently selected linking groups and Y and Z are each optionally present and if present is —O—, and X is —C(O)—, and wherein the linking group X is coupled to the insulin compound by a covalent bond; R PAG is a linear or branched carbon chain incorporating one or more alkylene glycol moiety wherein the alkylene glycol moiety is a substantially monodispersed PEG molecule having a formula (CH wherein the insulin is mammalian or an insulin analog thereof and wherein the modifying moiety is coupled to a lysine residue at position B28, B29 or B30 of insulin, wherein the modifying moiety has the following formula: where n is 2 to 7, and m is 2 to 5 thereby providing a monoconjugate.