Patent ID: 8481734
Filing Date: 2013-07-09
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: Formula I; wherein each of X each of Y each R each R 48 is independently —(CH 2 ) c OR 68 , —CH 2 (CHOH) c R 69 , —CH 2 (CHOH) c CO 2 H, —(CHCO 2 H) c CO 2 H, —(CH 2 ) c NR 70 R 71 , —CH[(CH 2 ) f NH 2 ] c CO 2 H, —CH[(CH 2 ) f NH 2 ] c CH 2 OH, —CH 2 (CHNH 2 ) c CH 2 NR 72 R 73 , —(CH 2 CH 2 O) e R 74 , —(CH 2 ) t CO(CH 2 CH 2 O) e R 75 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k NR 58 C(O)NR 59 (CH 2 ) l (CH 2 CH 2 O) o R 76 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k NR 60 C(S)NR 61 (CH 2 ) l (CH 2 CH 2 O) o R 77 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k C(O)NR 62 (CH 2 ) l (CH 2 CH 2 O) o R 78 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k S(O) 2 NR 63 (CH 2 ) l (CH 2 CH 2 O) o R 79 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k NR 64 S(O) 2 (CH 2 ) l (CH 2 CH 2 O) o R 80 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k NR 65 C(O)(CH 2 ) l (CH 2 CH 2 O) o R 81 , —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k NR 66 C(O)O(CH 2 ) l (CH 2 CH 2 O) o R 82 , or —(CH 2 ) u (CH 2 CH 2 O) j (CH 2 ) k OC(O)NR 67 (CH 2 ) l (CH 2 CH 2 O) o R 83 , —(CH 2 ) a SO 3 H, —(CH 2 ) a SO 3 − , —(CH 2 ) a OSO 3 H, —(CH 2 ) a OSO 3 − , —(CH 2 ) a NHSO 3 H, —(CH 2 ) a NHSO 3 − , —(CH 2 ) a PO 3 H 2 , —(CH 2 ) a PO 3 H − , —(CH 2 ) a PO 3 ═ , —(CH 2 ) a OPO 3 H 2 , —(CH 2 ) a OPO 3 H − , or —(CH 2 ) a OPO 3 ; each R 49 is independently —H, —(CH 2 ) c OR 68 , —CH 2 (CHOH) c R 69 , —CH 2 (CHOH) c CO 2 H, —(CHCO 2 H) c CO 2 H, —(CH 2 ) c NR 70 R 71 , —CH[(CH 2 ) f NH 2 ] c CO 2 H, —CH[(CH 2 ) f NH 2 ] c CH 2 OH, —CH 2 (CHNH 2 ) c CH 2 NR 72 R 73 , —(CH 2 CH 2 O) e R 74 , —(CH 2 ) c CO(CH 2 CH 2 O) e R 75 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k NR 58 C(O)NR 59 (CH 2 ) l (CH 2 CH 2 O) o R 76 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k NR 60 C(S)NR 61 (CH 2 ) l (CH 2 CH 2 O) o R 77 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k C(O)NR 62 (CH 2 ) l (CH 2 CH 2 O) o R 78 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k S(O) 2 NR 63 (CH 2 ) l (CH 2 CH 2 O) o R 79 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k NR 64 S(O) 2 (CH 2 ) l (CH 2 CH 2 O) o R 80 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k NR 65 C(O)(CH 2 ) l (CH 2 CH 2 O) o R 81 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k NR 66 C(O)O(CH 2 ) l (CH 2 CH 2 O) o R 82 , —(CH 2 ) i (CH 2 CH 2 O) j (CH 2 ) k OC(O)NR 67 (CH 2 ) l (CH 2 CH 2 O) o R 83 , —(CH 2 ) a SO 3 H, —(CH 2 ) a SO 3 − , —(CH 2 ) a OSO 3 H, —(CH 2 ) a OSO 3 − , —(CH 2 ) a NHSO 3 H, —(CH 2 ) a NHSO 3 − , —(CH 2 ) a PO 3 H 2 , —(CH 2 ) a PO 3 H − , —(CH 2 ) a PO 3 ═ , —(CH 2 ) a OPO 3 H 2 , —(CH 2 ) a OPO 3 H − , or —(CH 2 ) a OPO 3 ; each of R each of R each of R each of R each of R each of R each of R each (AA) is independently a polypeptide chain that includes one or more natural or unnatural α-amino acids linked together by peptide bonds; each (PS) is independently a sulfated or non-sulfated polysaccharide chain comprising one or more monosaccharide units connected by glycosidic linkages; each of ‘t’ and ‘u’ is independently 1, 2, 3, 4, or 5; each of ‘a’, ‘d’, ‘g’, ‘i’, ‘l’, and ‘q’ is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; each of ‘c’, ‘f’, ‘k’, and ‘p’ is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and each of ‘b’, ‘j’, ‘e’, ‘h’, ‘o’, and ‘s’ is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 or 100.