Patent ID: 7696229
Filing Date: 2010-04-13
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein A, B, D, E and G, are each independently CH, or CR ----- represents a single bond or a double bond; Q is C when ---- is a double bond, and Q is CH or N when ----- is a single bond; x is 0, 1, 2, 3, or 4; R Ar is selected from formulas (a)-(i)and (k)-(r): wherein formula (a) is substituted at least by a substitued or unsubstituted heterocyclic group; J is CR in formula (o), one K is N and the other is CH; W is O, S, or is absent; X is, in each instance independently, O or NR Y is O, NR Z is S or NR a is 1, 2, 3, 4 or 5; b, l, m and v are independently 0, 1, 2, 3 or 4; c, f, h, n, o, q, s, and u are independently 0, 1, 2 or 3; d, and e are independently 1, 2 or 3; g, i, j, and p are independently 0, 1 or 2; k and t are 0 or 1; R R R  an alkoxy having 1 to 8 carbon atoms, or  a heterocyclic group, which is saturated, partially saturated or unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, hydroxy, C R  a heterocyclic group, which is saturated, partially saturated or unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, hydroxy, C R R  alkoxy having 1 to 8 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times by halogen,  cycloalkyl having 3 to 10 carbon atoms, which is unsubstituted or substituted one or more times by halogen, hydroxy, oxo, cyano, C  cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted in the cycloalkyl portion and/or the alkyl portion one or more times by halogen, oxo, cyano, hydroxy, C  aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF  arylalkyl in which the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, wherein the arylalkyl radical is unsubstituted, substituted in the aryl portion one or more times by halogen, CF  a heterocyclic group, which is saturated, partially saturated or unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, hydroxy, C  a heterocycle-alkyl group, wherein the heterocyclic portion is saturated, partially saturated or unsaturated, and has 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, and the alkyl portion is branched or unbranched and has 1 to 5 carbon atoms, the heterocycle-alkyl group is unsubstituted, substituted one or more times in the heterocyclic portion by halogen, OCF R or a pharmaceutically acceptable salt thereof; with the following provisos: (i) when A, B, D, E and G are CH, and Ar is represented by forumula (b), and each X is O, then d is 3; (ii) said compound is not: 1-[(4-aminophenyl)sulfonyl]-5-nitro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-5-bromo-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-5-fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-6-chloro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-6-nitro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 5-(4-methyl-2-thiazolyl)-1-(phenylsulfonyl)-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-5-fluoro-3-(4-piperidinyl)-1H indole, 1-[(4-aminophenyl)sulfonyl]-6-chloro-3-(4-piperidinyl)-1H indole, or 3,6-dihydro-4-[5(4-methyl-2-thiazolyl)-1-(phenylsulfonyl)-1H-indol-3-yl)-1,1-dimethylethylester.