Patent ID: 6743778
Filing Date: 2004-06-01
Classification: A61K,A61P,C07K

Abstract:
A composition of matter of the formula(A1)a-F1-(A2)b and multimers thereof, wherein:F1 is an Fc domain of an antibody; A1 and A2 are each independently selected from -(L1)c-P1, -(L1)c-P1-(L2)d-P2, -(L1)c-P1-(L2)d-P2-(L3)e-P3, and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4; P1, P2, P3, and P4 are each independently of apolipoprotein AI (Apo-AI) amphipathic helix peptide or Apo-AI amphipathic helix peptide-mimetic domains; L1, L2, L3, and L4 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1.