Patent ID: 6649797
Filing Date: 2003-11-18
Classification: A61K,A61P,C07D,Y02A,Y10T

Abstract:
An aryl carbonyl compound that is capable of:(a) interacting with a molecule in a complex having a specific docking site which is positioned proximately to a nuclear localization signal of a protein in the complex; and (b) forming stable reversible covalent interactions with basic amino acid residues of the nuclear localization signal of the protein; said compound having a structure according to formula (I): â€ƒwherein A, independently, is CH3, CH2CH3, COH, COCH3, COCH2CH3, CH2COCH3, CH2COCH2CH3, C(CH3)2COCH3 or C(CH3)2COCH2CH3 P is 1 or 2; K is 0; and J is (i) H, (CH2)nNH2 wherein n is an integer from 0 to 6, a straight or branched C1-6 alkyl, a straight or branched C2-6 alkenyl or a straight or branched C1-6 alkoxy; (ii) a straight or branched C1-6 alkyl, a straight or branched C2-6 alkenyl or a straight or branched C1-6 alkoxy, wherein each group contains a nitrogen atom, or (iii) a mono- or poly-heterocyclic group having 3 to 20 atoms, at least one of which is a nitrogen atom and further wherein J does not contain a sulfur atom in any poly-heterocyclic group.