Patent ID: 6448246
Filing Date: 2002-09-10
Classification: A61P,C07D,G01N

Abstract:
A compound of the formula: or a pharmaceutically acceptable non-toxic salt thereof wherein:A is hydrogen, alkyl, alkenyl, alkynyl, aminoalkyl, or mono- or dialkylamino; X is S&boxH;O, or O&boxH;S&boxH;O; Ra, Rb, Rc, and Rd, independently represent i) hydrogen, halogen, hydroxy, amino, nitro, cyano, â€”SH, haloalkyl, or ii) lower alkyl, alkenyl, alkynyl, mono- or dialkylamino, C0-C6alkyl-Sâ€”C1-C6alkyl, C1-C6alkyl-SH, C0-C6alkyl-SOâ€”C1-C6alkyl, C0-C6alkyl-SO2â€”C1-C6alkyl, C0-C6alkyl-SO2H, alkoxy, or C3-C7 cycloalkyl, each of which is optionally substituted with â€”OR1 or â€”NR2R3; and Y is lower alkyl, cycloalkyl, or aryl substituted with a cycloalkylalkyl group, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted with i) halogen, hydroxy, amino, nitro, cyano, â€”SH, haloalkyl, C0-C6alkyl-SOâ€”C1-C6alkyl, C0-C6alkyl-SO2â€”C1-C6alkyl, C0-C6 alkyl-SO2H; or ii) lower alkyl, alkenyl, alkynyl, â€”OR1, â€”NR2R3, SR4, each of which is optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy, amino, â€”SH, mono- or di(C1-C6) alkylamino, â€”ZR1, or â€”Oâ€”G1â€”OR1; where Z is O, S, or NH; G1 is lower alkyl or cycloalkyl; R1 is hydrogen, lower alkyl or C3-C7 cycloalkyl, where each alkyl is optionally substituted with lower alkoxy, C3-C7 cycloalkoxy, or mono- or di(C1-C6) alkylamino; R2 and R3 are the same or different and represent hydrogen, lower alkyl, C3-C7 cycloalkyl; or R2 and R3 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring; and R4 is hydrogen, or lower alkyl or C3-C7 cycloalkyl, where each alkyl is optionally substituted with lower alkoxy, C3-C7 cycloalkoxy, or mono- or di(C1-C6) alkylamino.