Patent ID: 8921525
Filing Date: 2014-12-30
Classification: A61P,C07K

Abstract:
1. A mutant of a heavy chain humanized variable region (5H) of an anti-human epithelial cell growth factor receptor 1 (Her 1) antibody 528 that consists of the amino acid sequence SEQ ID NO:4, wherein the mutant differs from the amino acid sequence SEQ ID NO: 4 by the replacement of one or more of residues 52, 55, 63, 65, or 66 within its CDR2 with another amino acid, wherein TYR 52 of SEQ ID NO: 4 is replaced by Trp, and wherein, when the mutant is paired with the light chain variable region SEQ ID NO: 2 to form an antibody, the antibody binds human epithelial growth factor receptor 1.