Patent ID: 6630464
Filing Date: 2003-10-07
Classification: A61K,A61P,C07D

Abstract:
A method for treating a mammalian subject having leukemia, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and/or breast cancer, comprising:providing at least one compound selected from the group consisting of compounds having Formula 2where R and R1 are carbon or nitrogen, and with R1=carbon R1 is bonded to N1 by a double bond, R is nitrogen, X is hydrogen or halogen, and R2 is selected from the group consisting of alkyl and aryl amino, the compound having an IC50 for CDK4 of less than about 10 &mgr;M, and having an IC50 for CDC2 of more than about 60 &mgr;M and having an IC50 for CDK2/A of more than about 100 &mgr;M, and having an IC50 for CDK2/E of more than about 80 &mgr;M; and administering an effective amount of the compound to the mammalian subject having the cancer.