Patent ID: 6342245
Filing Date: 2002-01-29
Classification: A61K,A61P

Abstract:
A particle consisting of a solid dispersion comprising(a) a lipid lowering agent of formula an N-oxide, a stereochemically isomeric form, a mixture of two or more such forms, or a pharmaceutically acceptable acid addition salt thereof, wherein A and B taken together form a bivalent radical of formula:â€”N&boxH;CHâ€”â€ƒâ€ƒ(a), â€”CH&boxH;Nâ€”â€ƒâ€ƒ(b), â€”CH2â€”CH2â€”â€ƒâ€ƒ(c), â€”CH&boxH;CHâ€”â€ƒâ€ƒ(d), â€”C(&boxH;O)â€”CH2â€”â€ƒâ€ƒ(e), â€ƒâ€”CH2â€”C(&boxH;O)â€”â€ƒâ€ƒ(f),in the bivalent radicals of formula (a) and (b) the hydrogen atom may be replaced by C1-6alkyl; in the bivalent radicals of formula (c), (d), (e), (f), one or two hydrogen atoms may be replaced by C1-6alkyl; R1 is hydrogen, C1-6alkyl or halo; R2 is hydrogen or halo; R3 is hydrogen; C1-8alkyl; C3-6cycloalkyl; or C1-8alkyl substituted with hydroxy, oxo, C3-6cycloalkyl or aryl; Het is a heterocycle selected from the group consisting of pyridine; pyridine substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino or aryl; pyrimidine; pyrimidine substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)-amino or aryl; tetrazole; tetrazole substituted with C1-6alkyl or aryl; triazole; triazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)-amino; thiadiazole; thiadiazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino; oxadiazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino; imidazole; imidazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino; thiazole; thiazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino; oxazole; oxazole substituted with one or two substituents selected from C1-6alkyl, hydroxy, C1-6alkyloxy, trihalomethyl, amino, mono- or di(C1-6alkyl)amino; aryl is phenyl or phenyl substituted with C1-6alkyl or halo; and one or more pharmaceutically acceptable water-soluble polymers.