Patent ID: 8962757
Filing Date: 2015-02-24
Classification: A61K,A61P,C08F,C08G

Abstract:
1. A biocompatible delivery vector comprising: an anionic graft polymer comprising an anionic polymer backbone with pendent carboxylic acid groups and pendent chains comprising amphipathic polyetheramines propylene oxide moieties, bonded to a portion of said pendent carboxylic acid groups, wherein (a) the anionic graft polymer is physically bound to a complex comprising at least one cationic agent physically bound to at least one anionic antisense molecule, (b) the absolute value of the positive-to-negative (+/−) charge ratio of the delivery vector ranges from about 0.25 to about 4.7 between said anionic graft polymer and said complex of said cationic agent and said antisense molecule, (c) the molecular weight of the covalently bonded amphipathic polyetheramine moieties are between about 200 Daltons and about 5,000 Daltons; and (d) the anionic polymer has a graft density between about 1 and about 25 mole percent.