Patent ID: 6153616
Filing Date: 2000-11-28
Classification: C07D

Abstract:
A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR57## wherein: Ar is a phenyl group which is unsubstituted or substituted by 1-3 substituents each independently selected from the group consisting of halogen, CF.sub.3 and OCF.sub.3 ;R.sub.1 and R.sub.2 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl group which is unsubstituted or substituted by 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, with the proviso that where R.sub.1 is hydrogen, R.sub.2 is other than hydrogen, and vice versa;R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl group which is unsubstituted or substituted by 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, or R.sub.3 and R.sub.4 together form .dbd.S;R.sub.5 and R.sub.6 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl group which is unsubstituted or substituted by 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, or R.sub.5 and R.sub.6 together form .dbd.S;X is a direct bond;R.sub.7 is a group of the formula ##STR58## wherein the phenyl is additionally unsubstituted or substituted with 1-2 additional substituents each independently selected from the group consisting of (1) C.sub.1 -C.sub.4 alkyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, (2) C.sub.1 -C.sub.4 alkoxy, (3) halogen, (4) formyl, (5) carboxyl, (6) C.sub.1 -C.sub.4 acyloxy, (7) C.sub.1 -C.sub.4 alkoxycarbonylamino, (8) phenyl- or naphthyl-oxycarbonylamino, (9) semicarbazido, (10) formamido, (11) thioformamido, (12) hydroxy, (13) nitro, (14) amino, (15) furyl, (16) triazolyl, (17) thienyl, (18) oxazolyl, (19) imidazolyl and (20) triazolone-yl, andR is selected from the group consisting of (1) C.sub.1 -C.sub.10 alkyl which is unsubstituted or substituted by 1-5 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, (2) phenyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of (a) C.sub.1 -C.sub.4 alkyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, (b) C.sub.1 -C.sub.4 alkoxy, (c) halogen, (d) formyl, (e) carboxyl, (f) C.sub.1 -C.sub.4 acyloxy, (g) C.sub.1 -C.sub.4 alkoxycarbonylamino, (h) phenyl- or naphthyl-oxycarbonylamino, (i) semicarbazido, (j) formamido, (k) thioformamido, (l) hydroxy, (m) nitro, (n) amino, (o) furyl, (p) triazolyl, (q) thienyl, (r) oxazolyl, (s) imidazolyl, (t) triazolone-yl, (u) CF.sub.3 and (v) OCF.sub.3, (3) phenyl(C.sub.1 -C.sub.4 alkyl) which is unsubstituted or ring-substituted with 1-3 substituents each independently selected from the group consisting of (a) C.sub.1 -C.sub.5 alkyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, (b) halogen, (c) halo(C.sub.1 -C.sub.4 alkyl), (d) C.sub.1 -C.sub.4 alkoxy, (e) hydroxy, (f) amino, (g) carboxyl, (h) trifluoromethoxyl, (i) trifluoromethyl, (j) tetrafluoroethyl, (k) tetrafluoroethoxyl, (l) tetrafluoropropyl and (m) tetrafluoropropoxyl, (4) naphthyl(C.sub.1 -C.sub.4 alkyl) which may be substituted with 1-6 substituents selected from (a) C.sub.1 -C.sub.5 alkyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy and amino, (b) halogen, (c) (C.sub.1 -C.sub.4 alkyl)halo, (d) C.sub.1 -C.sub.4 alkoxy, (e) hydroxy, (f) amino, (g) carboxyl, (h) trifluoromethoxyl, (i) trifluoromethyl, (j) tetrafluoroethyl, (k) tetrafluoroethoxyl, (l) tetrafluoropropyl and (m) tetrafluoropropoxyl, (5) methoxyl, (6) trifluoromethoxyl, (7) trifluoromethyl, (8) trifluoroethyl, (9) tetrafluoroethyl, (10) tetrafluoroethoxyl, (11) tetrafluoropropyl and (12) tetrafluoropropoxyl.