Patent ID: 6011046
Filing Date: 2000-01-04
Classification: C07D

Abstract:
A compound of the formula: ##STR11## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent i) a hydrogen atom,ii) a hydroxyl group optionally substituted by a C.sub.1-6 alkyl-carbonyl, C.sub.6-10 aryl-carbonyl, C.sub.6-10 aryl-C.sub.1-6 alkyl-carbonyl, C.sub.1-6 alkylsulfonyl, C.sub.6-10 arylsulfonyl or C.sub.6-10 aryl-C.sub.1-6 alkylsulfonyl,iii) an amino group which may be substituted by 1 or 2 substituents selected from the group consisting of(a) a C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.6-14 aryl or C.sub.6-10 aryl-C.sub.1-6 alkyl group, each of which may be substituted by 1 to 5 substituents selected from the group consisting of hydroxyl, C.sub.1-3 alkoxy, C.sub.6-10 aryl-C.sub.1-6 alkoxy, C.sub.6-10 aryloxy, 5- to 10-membered heteroaryloxy, mercapto, C.sub.1-3 alkylthio, C.sub.1-3 alkylsulfonyl, C.sub.1-3 alkylsulfinyl, C.sub.6-10 aryl-C.sub.1-6 alkylthio, C.sub.6-10 aryl-C.sub.1-6 alkylsulfonyl, C.sub.6-10 aryl-C.sub.1-6 alkylsulfinyl, C.sub.6-10 arylthio, 5- to 10-membered heteroarylthio, C.sub.6-10 arylsulfonyl, 5- to 10-membered heteroarylsulfonyl, C.sub.6-10 arylsulfinyl, 5- to 10-membered heteroarylsulfinyl, halogen, C.sub.1-4 alkoxy-carbonyl, C.sub.2-3 alkanoyl, C.sub.2-3 alkanoyloxy, C.sub.2-3 alkanoylamido, C.sub.1-4 alkoxy-carbonylamino, 3- to 6-membered cyclic amino, carboxyl, carbamoyl and amino optionally substituted by 1 or 2 substituents selected from the group consisting of C.sub.1-3 alkyl, C.sub.6-10 aryl-C.sub.1-6 alkyl, C.sub.6-10 aryl and 5- to 10-membered heteroaryl, and(b) a 5- to 10-membered heterocyclic group containing, besides carbon atoms, 1 to 3 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom, which group may be substituted by 1 to 5 substituents selected from the group consisting of amino, mono-C.sub.1-3 alkylamino, di-C.sub.1-3 alkylamino, halogen, nitro, sulfo, cyano, hydroxyl, carboxyl, C.sub.1-5 alkyl, C.sub.6-14 aryl, C.sub.1-3 alkoxy, C.sub.1-4 alkyl-carbonyl and C.sub.1-3 alkylmercapto,iv) a C.sub.1-6 alkoxy group optionally substituted by 1 to 5 substituents selected from the group consisting of amino, mono-C.sub.1-3 alkylamino, di-C.sub.1-3 alkylamino, halogen, hydroxyl, C.sub.1-6 alkoxy and C.sub.1-6 alkylmercapto, orv) a C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.6-14 aryl or C.sub.6-10 aryl-C.sub.1-6 alkyl group, each of which may be substituted by 1 to 5 substituents selected from the group consisting of hydroxyl, C.sub.1-3 alkoxy, C.sub.6-10 aryl-C.sub.1-6 alkoxy, C.sub.6-10 aryloxy, 5- to 10-membered heteroaryloxy, mercapto, C.sub.1-3 alkylthio, C.sub.1-3 alkylsulfonyl, C.sub.1-3 alkylsulfinyl, C.sub.6-10 aryl-C.sub.1-6 alkylthio, C.sub.6-10 aryl-C.sub.1-6 alkylsulfonyl, C.sub.6-10 aryl-C.sub.1-6 alkynylsulfinyl, C.sub.6-10 arylthio, 5- to 10-membered heteroarylthio, C.sub.6-10 arylsulfonyl, 5- to 10-membered heteroarylsulfonyl, C.sub.6-10 arylsulfinyl, 5- to 10-membered heteroarylsulfinyl, halogen, C.sub.1-4 alkoxy-carbonyl, C.sub.2-3 alkanoyl, C.sub.2-3 alkanoyloxy, C.sub.2-3 alkanoylamido, C.sub.1-4 alkoxy-carbonylamino, 3- to 6-membered cyclic amino, carboxyl, carbamoyl and amino optionally substituted by 1 or 2 substituents selected from the group consisting of C.sub.1-3 alkyl, C.sub.6-10 aryl-C.sub.1-6 alkyl, C.sub.6-10 aryl and 5- to 10-membered heteroaryl, orR.sup.2 and R.sup.3, taken together with the adjacent two carbon atoms, form a C.sub.6-14 aromatic hydrocarbon or C.sub.5-8 cycloalkene ring which may be substituted by 1 to 3 substituents selected from the group consisting of a C.sub.1-3 alkyl, C.sub.1-3 alkoxy, hydroxyl, halogen and amino;R.sup.4 represents a C.sub.1-6 alkyl group;R.sup.5 represents a hydroxyl group optionally substituted byi) a C.sub.1-6 alkyl, C.sub.6-10 aryl, C.sub.7-10 aralkyl, c.sub.1-6 alkyl-carbonyl, C.sub.6-10 aryl-carbonyl, C.sub.7-10 aralkyl-carbonyl, tetrahydropyranyl or tetrahydrofuranyl group, each of which may be substituted by 1 to 3 substituents selected from the group consisting of halogen, C.sub.1-6 alkyl, C.sub.6-10 aryl, C.sub.7-10 aralkyl and nitro, orii) a formyl or silyl group, each of which may be substituted by 1 to 3 substituents selected from the group consisting of C.sub.1-6 alkyl, C.sub.6-10 aryl and C.sub.7-10 aralkyl;R.sup.6 and R.sup.7, taken together with the adjacent nitrogen atom, form a 3- to 7-membered N-containing heterocyclic ring optionally containing, besides carbon atoms and a nitrogen atom, 1 to 3 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom, which ring maybe substituted by 1 to 5 substituents selected from the group consisting of amino, mono-C.sub.1-3 alkylamino, di-C.sub.1-3 alkylamino, halogen, nitro, sulfo, cyano, hydroxyl, carboxyl, C.sub.1-5 alkyl, C.sub.6-14 aryl, C.sub.1-3 alkoxy, C.sub.1-4 alkyl--carbonyl and C.sub.1-3 alkylmercapto;m represents 1 or 2; andn represents an integer of 1 to 5;or a salt thereof.