Patent ID: 6482819
Filing Date: 2002-11-19
Classification: A61P,C07D

Abstract:
A compound of the formula (I), a stereoisomer or an acid addition salt thereof, whereR1 and R2 represent independently hydrogen, halogen, a C1-4 alkyl, C1-4 alkoxy, nitro, trifluoromethyl group or a group of the formula â€”NR8R9, wherein R8 and R9 represent independently hydrogen, a C1-4 alkyl group or a group of the formula â€”COR10, wherein R10 represents hydrogen, an optionally substituted C1-4 alkyl group, C6-10 aryl group, C1-4 alkoxy group, C3-5 cycloalkyl group, C2-6 alkenyl group, C3-5 cycloalkoxy group or a group of the formula â€”NR11R12, wherein R11 and R12 represent independently hydrogen, a C1-4 alkyl group, C3-5 cycloalkyl group or C6-10 aryl group, x represents hydrogen or chlorine atom, Y represents chlorine or bromine atom, A represents a group of the formula (a) or (c) â€ƒwherein R3, R4 and R6 represent independently hydrogen, a C1-4 alkyl group, C3-5 cycloalkyl group, C2-4 alkenyl group, C2-4 alkinyl group or C6-10 aryl group which can optionally be substituted by one or more halogen, nitro, alkoxy, or amino groups; a heteroaryl group selected from the group consisting of thienyl, furyl and pyridyl; a group of the formula â€”COOR13 or â€”CONR14R15, wherein R13 represents hydrogen or C1-4 alkyl group, R14 and R15 represent independently hydrogen or a C1-4 alkyl group.