Patent ID: 7416849
Filing Date: 2008-08-26
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. An isolated nucleic acid that encodes a low density lipoprotein receptor-related protein 5 (LRP5) or a low density lipoprotein receptor-related protein 6 (LRP6), wherein said encoded LRP5 or LRP6 differs from a mammalian LRP5 or LRP6 sequence in propeller 1 of said LRP5 or LRP6, and wherein said different LRP5 or LRP6 has one or more of the following activities: (a) said different LRP or LRP6 increases bone mass, or (b) said different LRP5 or LRP6 decreases a lipid in a subject.