Patent ID: 6040293
Filing Date: 2000-03-21
Classification: A61K,C07K

Abstract:
A compound in isolated form of the formulaX'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1) (SEQ ID NO:1)including the salts, esters, amides, and acylated forms thereof,said compound having antimicrobial activity and an .alpha.-helical conformation,wherein X is a hydrophobic amino acid residue selected from the group consisting of Tyr, Val, Ile, Leu, Met, Phe, and Trp;X' is a small or a hydrophobic amino acid residue selected from the group consisting of Gly, Ser, Ala, Thr, Tyr, Val, Ile, Leu, Met, Phe, and Trp;B is a basic amino acid residue selected from the group consisting of Arg, Lys, and His;B' is a basic or a polar/large amino acid residue selected from the a group consisting of Arg, Lys, His, Asn, and Gln;B* is a basic or a hydrophobic amino acid residue selected from the group consisting of Arg, Lys, His, Tyr, Val, Ile, Leu, Met, Phe, and Trp;U is a small amino acid residue selected from the group consisting of Gly, Ser, Ala, and Thr;Z is a polar/large amino acid residue selected from the group consisting of Asn and Gln; andwherein one or more X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 may be truncated.