Patent ID: 8168607
Filing Date: 2012-05-01
Classification: A01K,A61K,A61P,C07H,C12N

Abstract:
1. A method of treating a diabetic patient suffering from an eye disease which comprises administering to the patient intravitreally a composition comprising a double-stranded compound having the structure: wherein each of A, C, G and U represents a ribonucleotide; wherein in alternating ribonucleotides in each of the antisense strand and the sense strand, a 2′-O-methyl group is present in the sugar residue; wherein the ribonucleotide at each of the 5′ terminus and the 3′ terminus of the antisense strand comprises a 2′-O-methyl group in the sugar residue; wherein the ribonucleotide at each of the 5′ terminus and the 3′ terminus of the sense strand is unmodified in the sugar residue; wherein each ribonucleotide at the 5′ terminus and the 3′ terminus of the antisense strand and of the sense strand is independently phosphorylated or non-phosphorylated; and wherein each vertical line (|) represents base pairing; and a pharmaceutically acceptable carrier or excipient; wherein the composition is administered in an amount effective to treat the patient.