Patent ID: 6830893
Filing Date: 2004-12-14
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of screening for agonist and antagonists comprising:providing a peptide agent having a sequencec corresponding to T20/DP178 of SEQ ID NO:197 or a carboxy truncation, amino truncation thereof having a sequence selected from the group consisting of SEQ ID NO:2-96; providing a cell having thereon a formyl peptide receptor (FPR) menber that interacts with said peptide agent; contacting said peptide agent with said cell under conditions that low said peptide agent to interact with said FPR member on said cell; identifying the presence or absence of signal transduction generate in response to the interaction of said peptide agent with said FPR member; and characterizing said peptide agent as being an antagonist if said signal transduction is identified as being absent or charaterizing said peptide agent as being an agonist if said signal traduction is identified as being present.