Patent ID: 7387271
Filing Date: 2008-06-17
Classification: A61K,A61P

Abstract:
1. An immunostimulatory composition suitable for administration to a human subject in need of immunotherapy comprising: (i) at least one Toll-Like Receptor (TLR) agonist which is selected from the group consisting of TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, and TLR8 agonists; and (ii) at least one CD40 agonist that directly binds CD40; and (iii) a pharmaceutically acceptable carrier, wherein (i) and (ii) are each comprised in an amount such that, in combination with the other, are effective to produce a synergistic increase in a human subject in an immune response to an antigen upon administration to a human subject in need of immunotherapy.