Patent ID: 9102918
Filing Date: 2015-08-11
Classification: A61K,A61M,C12N

Abstract:
1. A method for transfusing blood to a mammalian subject suffering from a disorder characterized by reduced oxygenation of tissue, the method comprising, at the point of care, the steps of: (a) adding an enhancement composition to a volume of red blood cells, forming a treated red blood cell composition, wherein the enhancement composition comprises a rejuvenating material selected from the group consisting of inosine, adenine, pyruvate, sodium phosphate, and mixtures thereof; (b) incubating the treated red blood cell composition, forming an incubated red blood cell composition, wherein the incubated red blood cell composition comprises red blood cells with 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) levels increased compared with 2,3-DPG and ATP levels found in normal blood of the subject; and (c) administering the incubated red blood cell composition to the subject,