Patent ID: 6288083
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A method of treating a disease associated with aberrant leukocyte recruitment and/or activation mediated by chemokine receptor function comprising administering to a subject in need thereof an effective amount of a compound represented by the following structural formula: ##STR8##or physiologically acceptable salt thereof, wherein:Ar.sup.1 is a substituted or unsubstituted pyridyl group;Ar.sup.2 is a substituted or unsubstituted aromatic carbocyclic or group;n is an integer from one to four;M is >CR.sup.1 R.sup.2 ;R.sup.1 is --H, --OH, an aliphatic group, --O-(aliphatic group), --O-(substituted aliphatic group), --SH, --S-(aliphatic group), --S-(substituted aliphatic group), --OC(O)-(aliphatic group), --O--C(O)-(substituted aliphatic group), --CN, --COOH, --CO--NR.sup.3 R.sup.4 or --NR.sup.3 R.sup.4 ;R.sup.2 is --OH, an acyl group, a substituted acyl group, --NR.sup.5 R.sup.6, a substituted or unsubstituted C.sub.2 -C.sub.20 linear alkyl, alkenyl or alkynyl group, a substituted or unsubstituted C.sub.3 -C.sub.20 branched alkyl or alkenyl group, a substituted or unsubstituted C.sub.4 -C.sub.20 branched alkynyl group, a substituted or unsubstituted C.sub.3 -C.sub.20 cyclic alkyl or alkenyl group, a substituted or unsubstituted C.sub.9 -C.sub.20 cyclic alkynyl group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; wherein:said acyl group is an aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl; andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently --H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; orR.sup.1 and R.sup.2, R.sup.3 and R.sup.4, or R.sup.5 and R.sup.6 taken together with the atom to which they are bonded, form a substituted or unsubstituted non-aromatic heterocyclic ring.