Patent ID: 9133157
Filing Date: 2015-09-15
Classification: A61P,C07B,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R R Ring A is: wherein the asterisks (*) denote the points of attachment to the rest of the compound; R R R wherein the asterisk (*) denotes the point of attachment to the rest of the compound; R each X m is an integer equal to 0 or 1; n is an integer equal to 0 or 1; R R R R AryQ is an aryl which is independently phenyl, naphthyl, tetrahydronaphthyl, indenyl, or dihydroindenyl, wherein the aryl is optionally substituted with from 1 to 3 X HetQ is a heteroaryl which is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein each N is optionally in the form of an oxide or (ii) a 9- or 10-membered bicyclic, fused ring system containing from 1 to 3 heteroatoms independently selected from N, O and S, and wherein at least one of the rings is aromatic, each N in a ring is optionally in the form of an oxide, and each S is optionally S(O) or S(O) HetQ′ is independently a dihydro derivative of the heteroaryl defined in HetQ wherein the dihydro derivative is not or does not contain an aromatic ring; and wherein the derivative is optionally substituted with from 1 to 3 oxo substituents; CycA is a C CycB is a C AryA is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 3 halo substituents; AryC is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 3 halo substituents; HetA is a heteroaryl which is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, or (ii) is a fused, 9- or 10-membered heterobicyclic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, and wherein at least one of the rings is aromatic, each N in a ring is optionally in the form of an oxide, and each S is optionally S(O) or S(O) HetC is a heteroaryl which is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, or (ii) is a fused, 9- or 10-membered heterobicyclic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, and wherein at least one of the rings is aromatic, each N in a ring is optionally in the form of an oxide, and each S is optionally S(O) or S(O) each HetD is independently a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein the heteroaromatic ring is optionally substituted with from 1 to 3 substituents each of which is independently C