Patent ID: 6069151
Filing Date: 2000-05-30
Classification: A61K,C07D,Y02A

Abstract:
A compound of the formula (i) ##STR5## wherein R.sub.1 is selected from the group consisting of C.sub.1-6 alkoxy (alkyl portion optionally substituted with one or more halogens), and thioalkyl;R.sub.2, R.sub.3 and R.sup.4, which may be the same or different, are each selected from the group consisting of OR.sub.11, COR.sub.7, CN, CO.sub.2 R.sub.8, C(.dbd.NOR.sub.7)R.sub.7, alkyl-C(.dbd.NOR.sub.7)R.sub.7, halogen, CF.sub.3, CONR.sub.12 R.sub.13, NR.sub.9 R.sub.10 and R.sup.7 ;R.sub.5 represents H or a substituent selected from the group consisting of halogen, arylalkyl, heteroarylalkyl, heterocycloalkyl, alkyl, hydroxy, alkoxy, CO.sub.2 R.sub.8, SO.sub.2 NR.sub.12 R.sub.13, CONR.sub.12 R.sub.13, --CN, NR.sub.9 R.sub.10, COR.sub.11, S(O).sub.n R.sub.11 and tetrazolyl;R.sub.7 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl and heterocycloalkyl, any of which may be optionally substituted at any position with R.sub.16 ;R.sub.8 is selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl and heterocycloalkyl;R.sub.9 is selected from the group consisting of alkylcarbonyl, alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl, heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl and alkylsulphonyl and R.sub.10 is selected from the group consisting of H and R.sub.11, or NR.sub.9 R.sub.10 represents a heterocyclic ring optionally substituted with one or more R.sub.15 ;R.sub.11 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl and heterocycloalkyl;R.sub.12 and R.sub.13, which may be the same or different, each representing R.sub.7, or NR.sub.12 R.sub.13 represents a heterocyclic ring optionally substituted with one or more R.sub.15 ;R.sub.15 is selected from the group consisting of alkyl, arylalkyl and heteroarylalkyl;R.sup.16 is selected from the group consisting of halogen, hydroxy, OR.sub.11, NR.sub.9 R.sub.10, CN, CO.sub.2 H, CO.sub.2 R.sub.11, CONR.sub.12 R.sub.13 and COR.sub.11 ;n represents 0-2; andQ represents phenyl or pyridyl, optionally substituted at any position(s) with one or more substituents R.sub.5 ;or a pharmaceutically-acceptable salt thereof; andexcluding 5-phenyl-8-mercaptoquinoline, 8-methoxy-5-phenylquinoline, 8-methoxy-5-[2-(t-butylcarbonylamino)phenyl]quinoline and 8-methoxy-5-[2-(t-butylcarbonylamino)-4-methoxyphenyl]quinoline).