Patent ID: 6440999
Filing Date: 2002-08-27
Classification: C07C

Abstract:
A method for inhibiting proliferation of vascular smooth muscle cells, or for inhibiting thickening or vascular stenosis following percutaneous transluminal coronary angioplasty, comprising administering to a patient in need of said therapy an effective amount for said therapy of a compound of formula (1) wherein X is an oxygen atom;R1 is a hydrogen atom or an acyl group; R2 is a hydrogen atom, a lower alkyl group or a lower alkenyl group; R3 and R4 are taken together to form a 5-membered ring; R5 is a substituted or unsubstituted alkyl group having 1 carbon atom; and R6 is a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted alkenyl group having 2 to 20 carbon atoms, a substituted or unsubstituted alkynyl group having 2 to 20 carbon atoms, or a substituted or unsubstituted aryl group; provided that R6 is nil when R3 and R4 are taken together to form a benzofuran ring.