Patent ID: 8541549
Filing Date: 2013-09-24
Classification: A61K,C07K,G01N

Abstract:
1. An annexin derivative, comprising: the amino acid sequence of SEQ ID NO: 1 wherein residues 101 and 260 of SEQ ID NO: 1 have been substituted with cysteine residues, wherein said cysteine residues are conjugated to polarity sensitive fluorophore N,N′-Dimethyl-N-(iodoacetyl)-N′(7-nitrobenz-2-oxa-1,2-diazol-4-yl)ethylenediamine (IANBD) or 6-Bromoacetyl-2-dimethylaminonaphthalene (BADAN), and wherein residues 113 and 302 of SEQ ID NO: 1 are substituted with an amino acid other than cysteine or lysine.