Patent ID: 8263740
Filing Date: 2012-09-11
Classification: A61K,A61P,C07C,C07D,C07K,C12P,G01N,Y02A,Y02P

Abstract:
1. A method of producing a polypeptide comprising at least one amino acid having a structure of Formula (I): the method comprising incorporating the amino acid of Formula (I) into a terminal or internal position within the polypeptide, wherein: A is arylene, substituted arylene; B is a linker selected from the group consisting of lower alkylene, substituted lower alkylene, lower alkenylene, substituted lower alkenylene, lower heteroalkylene, substituted lower heteroalkylene, —S—, —S-(alkylene or substituted alkylene)-, —S(O) J is R is H, alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl; each R″ is independently H, alkyl, substituted alkyl, or a protecting group, or when more than one R″ group is present, two R″ optionally form a heterocycloalkyl; R R each of R or the -A-B-J-R groups together form a bicyclic or tricyclic cycloalkyl or heterocycloalkyl comprising at least one carbonyl group, including a dicarbonyl group, protected carbonyl group, including a protected dicarbonyl group, or masked carbonyl group, including a masked dicarbonyl group; or the -J-R group together forms a monocyclic or bicyclic cycloalkyl or heterocycloalkyl comprising at least one carbonyl group, including a dicarbonyl group, protected carbonyl group, including a protected dicarbonyl group, or masked carbonyl group, including a masked dicarbonyl group.