Patent ID: 8058512
Filing Date: 2011-11-15
Classification: C07K,C12N

Abstract:
1. A method for producing a bioactive recombinant Transforming Growth Factor-β (TGF-β) protein in vivo in a plant host system, comprising transforming said plant host system with a chimeric nucleic acid sequence that encodes a TGF-β protein wherein said chimeric nucleic acid sequence comprises a first nucleic acid sequence that regulates transcription in said plant host system, a second nucleic acid sequence encoding a signal sequence and a third nucleic acid sequence encoding a full length bioactive TGF-β protein or a bioactive TGF-β protein C-terminal fragment; cultivating the transformed plant host system under conditions to express said bioactive TGF-β protein in vivo; and recovering said in vivo expressed bioactive TGF-β protein from said transformed plant host system.