Patent ID: 8008015
Filing Date: 2011-08-30
Classification: C12Q

Abstract:
1. Method for determining the risk of a human individual of developing restenosis after implantation of a stent which comprises: a) obtaining genomic DNA from a sample of said human individual; b) analyzing said sample to determine the genotype of at least one of the single-nucleotide polymorphisms (SNPs) selected from the group consisting of: rs350099, rs350104, rs164390 and rs875459, in the CCNB1 gene, c) identifying the presence of a genotype indicative of an increased risk of developing restenosis; wherein the presence of a genotype selected from the group consisting of: the presence of the TT genotype of rs350099 relative to a human individual that has a CC or CT genotype for this SNP, the presence of the CC genotype of rs350104 relative to a human individual that has a TT or TC genotype for this SNP, the presence of the GG genotype of rs164390 relative to a human individual that has a TT or GT genotype for this SNP and/or the presence of the GG genotype of rs875459 relative to a human individual that has a TT or GT genotype for this SNP, is indicative of an increased risk of developing restenosis; and d) determining the risk of said individual of developing restenosis after implantation of a stent.