Patent ID: 6048858
Filing Date: 2000-04-11
Classification: A61K,A61P,C07C,C07D,C07J,C07K

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof: ##STR19## wherein R.sub.a is a lower alkyl group, a cycloalkyl group, an aryl group or a heteroaryl group;D is(i) a covalent bond;(ii) --C(R.sub.a)--O--C(O)--Y--(C(R.sub.b)(R.sub.c)).sub.p --T--, wherein R.sub.a is a lower alkyl group, a cycloalkyl group, an aryl group or a heteroaryl group; Y is oxygen, sulfur or NR.sub.i, wherein R.sub.i is a hydrogen atom or a lower alkyl group; R.sub.b and R.sub.c are each independently a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, an alkylamino group or a dialkylamino group, or R.sub.b and R.sub.c taken together are a cycloalkyl group or a bridged cycloalkyl group; p is an integer from 1 to 6; and T is a covalent bond, oxygen, sulfur or nitrogen; or(iii) --(CO)--T.sub.1 --(C(R.sub.b)(R.sub.c)).sub.p --T.sub.2 --, wherein T.sub.1 and T.sub.2 are each independently a covalent bond, oxygen, sulfur or nitrogen; R.sub.b and R.sub.c are each independently a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, an alkylamino group or a dialkylamino group, or R.sub.b and R.sub.c taken together are a cycloalkyl group or a bridged cycloalkyl group; p is an integer from 1 to 6;Z is an aryl group or a heteroaryl group; andA.sub.1, A.sub.2 and A.sub.3 comprise the other subunits of a 5- or 6-membered monocyclic aromatic ring and each of A.sub.1, A.sub.2 and A.sub.3 is independently:(1) C--R.sub.1 wherein R.sub.1 at each occurrence is independently a hydrogen atom, a lower alkyl group, a lower haloalkyl group, an alkoxyalkyl group, a halogen atom or a nitro group;(2) N--R.sub.d, wherein R.sub.d at each occurrence is independently a covalent bond to an adjacent ring atom in order to render the ring aromatic, a hydrogen atom, a lower alkyl group, a cycloalkyl group, an arylalkyl group, an aryl group or a heteroaryl group;(3) a sulfur atom;(4) an oxygen atom; or(5) B.sub.a .dbd.B.sub.b, wherein B.sub.a and B.sub.b are each independently a nitrogen atom or C--R.sub.1, wherein R.sub.1 at each occurrence is independently a hydrogen atom, a lower alkyl group, a lower haloalkyl group, an alkoxyalkyl group, a halogen atom or a nitro group.