Patent ID: 6010862
Filing Date: 2000-01-04
Classification: C07K,G01N,Y10S

Abstract:
In a method of analyzing a body fluid sample for the presence of analyte indicative of a physiological condition, comprising the steps of contacting the body fluid sample with an immunological binding partner which binds to the analyte, detecting binding of the immunological binding partner to the analyte, and correlating any detected binding to the physiological condition, the improvement comprising contacting the body fluid sample with an immunological binding partner which binds to(Gln)-(Tyr)-(Ser)-(Tyr)-(Asp)-(Val)-Hyl- .vertline. (Gln)-(Tyr)-(Ser)-(Tyr)-(Asp)-(Val)-Hyl- .vertline. (Gly)-Ile-Hyl- -Ser-Gly-Val-Ala-Val-Gly-Gly -Ser-Gly-Val-Ala-Val-Gly-Gly -Gly-His-Arg wherein the cross-linking residue depicted as Hyl-Hyl-Hyl is hydroxylysyl pyridinoline and the parentheses indicate optional amino acid residues, and correlating any detected binding to degradation of type III collagen in vivo.