Patent ID: 8399018
Filing Date: 2013-03-19
Classification: A61K

Abstract:
1. A method of treating otic disorders selected from the group consisting of Meniere's Disease, endolymphatic hydrops, progressive hearing loss, dizziness, vertigo and tinnitus in an individual in need thereof comprising intratympanic administration of a sterile pharmaceutical composition into the ear, the composition comprising: an auris acceptable thermoreversible aqueous gel comprising a copolymer of polyoxyproplene and polyoxyethylene in an amount sufficient to provide a non-gelation viscosity that allows injection at or about room temperature with a needle having a gauge in the range of 18-31 through the tympanic membrane to an area on or near the round window membrane, and with a gelation viscosity between about 15,000 cP and about 1,000,000 cP and a gelation temperature of between about room temperature and about body temperature; and a multiparticulate ion channel modulating agent such that sustained release of the ion channel modulating agent into the ear occurs for a period of at least 5 days; provided that the ion channel modulating agent is a non-corticosteroid ion channel modulating agent.