Patent ID: 6589504
Filing Date: 2003-07-08
Classification: A61K,A61P,C07D

Abstract:
A method for chemically tagging the aggregation of amyloid fibrils comprising the steps of:(a) administering a compound of the following formula to a mammal or contacting said compound with a fluid or tissue sample taken from the mammal, the compound having the following formula: â€ƒor a pharmaceutically acceptable salt, ester, solvate, or prodrug thereof, wherein: R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, triflouromethyl, trifluoromethylether, halo, and a group of the formula â€”OR7, wherein R7 is alkyl or aryl; and R6 is a benzopyridinyl group optionally substituted with one to three substituents selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, triflouromethyl, trifluoromethylether, halo, and a group of the formula â€”OR7, wherein R7 is alkyl or aryl; wherein said alkyl groups at each occurrence are optionally substituted with alkoxy, aryl, or halo; said aryl groups at each occurrence are optionally substituted with alkyl, alkoxy, or halo; and one or more atoms in the compound of formula (I) optionally is replaced with a radiolabeled atom; and (b) allowing the compound to associate with the amyloid fibrils.