Patent ID: 6750321
Filing Date: 2004-06-15
Classification: A61K,A61P,C07K,Y10S

Abstract:
A constrained helical peptide comprising a sequence of nine amino acid residues having a first terminal residue and a second terminal residue, wherein said residues flank an internal sequence of seven amino acids and have side-chains covalently bonded to each other to form a locking moiety and thereby constrain the peptide, wherein said peptide inhibits the binding of IGF-I to IGFBP-1, and wherein the internal sequence is Xaa(7)LeuAlaXaa(10)Xaa(11)Xaa(12)Xaa(13) (SEQ ID NO:31), wherein Xaa(7), Xaa(11), Xaa(12), and Xaa(13) are independently Nal(1), Lys, His, Phe, Trp, Tyr, Pro, Gln, or Met, and Xaa(10) is any amino acid.