Patent ID: 7416858
Filing Date: 2008-08-26
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A pharmaceutical composition comprising a pharmaceutically acceptable diluent and a covalent conjugate between a poly(alkylene oxide) and a glycosylated or non-glycosylated peptide, wherein said poly(alkylene oxide) is conjugated to said peptide via a glycosyl linking group wherein said glycosyl linking group is interposed between and covalently linked to both said peptide and said poly(alkylene oxide), wherein said covalent conjugate is formed by contacting said peptide with at least one glycosyltransferase and at least one modified sugar donor under conditions suitable for said at least one glycosyltransferase to transfer a modified sugar moiety of said at least one modified sugar donor to said peptide, thereby forming said covalent conjugate, and wherein said modified sugar moiety comprises said poly(alkylene oxide).