Patent ID: 9200032
Filing Date: 2015-12-01
Classification: A61K,A61P,C07K

Abstract:
1. A process for obtaining a liquid IgG composition from an IgG solution partly purified from human plasma, comprising the steps of: a) diafiltering the partly purified IgG solution; b) stabilising the solution obtained in step a); c) heat treating the solution obtained in step b) whereby no more than 3% high molecular weigh aggregates and polymers are generated; d) selectively adsorbing at least 85% of the high molecular weight aggregates and polymers in step c) by cation exchange chromatography; and e) diafiltering the solution obtained in step d), whereby the liquid IgG composition is obtained , wherein the liquid IgG composition is stable for at least 1 year at a temperature of 2-30° C. and a pH of 4.6-5.8.