Patent ID: 8389511
Filing Date: 2013-03-05
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [Chemical formula] wherein R 1a is a halogen atom, a hydroxy group, a formyl group, a carboxyl group, a cyano group, an optionally substituted C 1-6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally substituted C 2-6 alkynyl group, an optionally substituted C 3-6 cycloalkyl group, an optionally substituted C 5-6 cycloalkenyl group, an optionally substituted C 1-6 alkylthio group, an optionally substituted C 6-10 arylthio group, an optionally substituted C 1-6 alkylsulfonyl group, an optionally substituted C 1-6 alkoxy group, an optionally substituted C 3-6 cycloalkoxy group, an optionally substituted C 5-6 cycloalkenyloxy group, an optionally substituted amino group, an optionally substituted aminocarbonyl group, an optionally substituted C 1-4 alkoxycarbonyl group, an optionally substituted C 1-4 alkylcarbonyl group, an optionally substituted C 6-10 arylcarbonyl group, an optionally substituted C 6-10 aryl group, an optionally substituted C 6-10 aryloxy group, an optionally substituted C 7-14 aralkyloxy group, or an optionally substituted 5- to 10-membered monocyclic or polycyclic heteroaryl group; R R R [Chemical formula] (in which R R [Chemical formula] (wherein D is an oxygen atom, a sulfur atom, —SO 2 —, —NR 5 —, —NR 5 CO—, —NR 5 SO 2 —, —NR 5 CONR 5 —, —CH(R 6 )—, or —CH(R 6 )CH 2 —, R 5 is a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 1-4 alkoxycarbonyl group, an optionally substituted C 1-4 alkylsulfonyl group, or an optionally substituted C 6-10 arylsulfonyl group, R 6 is an hydrogen atom, an optionally substituted C 1-6 alkoxy group, an optionally substituted C 3-6 cycloalkoxy group, an optionally substituted C 7-14 aralkyloxy group, or an optionally substituted aminocarbonyloxy group, p and q are independently 0, 1 or 2); R [Chemical formula] in which R 1z is a hydrogen atom, a halogen atom, a C 1-4 alkyl group or a C 1-4 alkoxy group, and r is 1, 2, 3 or 4; R R B is a hydrogen atom, an optionally substituted C R s is 0, 1 or 2 provided that when A is —(CH n is 0, 1 or 2.