Patent ID: 9132085
Filing Date: 2015-09-15
Classification: A61K,A61P

Abstract:
1. An implantable drug depot useful for localized delivery to a site beneath the skin of a patient, the drug depot comprising: a therapeutically effective amount of bupivacaine or pharmaceutically acceptable salt thereof and clonidine or pharmaceutically acceptable salt thereof, wherein the drug depot is capable of releasing the bupivacaine or pharmaceutically acceptable salt thereof and clonidine or pharmaceutically acceptable salt thereof over a period of at least one day, wherein the bupivacaine is in the form of a base and the clonidine is in the form of a salt and the drug depot has a modulus of elasticity of about 2 ×10 4 to about 5 ×10 5 dynes /cm 2 , and wherein the drug depot comprises a polymer having an inherent viscosity of from about 0.10 dL/g to about 1.2 dL/g, and the ratio of clonidine to bupivacaine is about 1:5, and wherein the drug depot further comprises a plasticizer comprising mPEG.