Patent ID: 6635751
Filing Date: 2003-10-21
Classification: C07K

Abstract:
An isolated nucleic acid encoding an activated form of ATF6, or the complementary strand thereto, wherein said activated form of ATF6 is p50ATF6 resulting from processing by endoplasmic reticulum stress, a polypeptide obtainable by expression of DNA encoding p50ATF6, or a polypeptide comprising a region of 1st to 373rd amino acids or a region of 1st to 366th amino acids in ATF6, and wherein said nucleic acid is selected from the group consisting of:(a) a nucleic acid having a nucleotide sequence encoding an amino acid sequence as shown in amino acid numbers: 1 to 373 in SEQ ID NO: 32; (b) a nucleic acid having a nucleotide sequence encoding an amino acid sequence as shown in amino acid numbers: 1 to 366 in SEQ ID NO: 32; (c) a nucleic acid having a nucleotide sequence as shown in base numbers: 69 to 1187 in SEQ ID NO: 31; (d) a nucleic acid having a nucleotide sequence as shown in base numbers: 69 to 1166 in SEQ ID NO: 31; and (e) a nucleic acid capable of hybridizing to a strand complementary to the nucleic acid of any one of (a) to (d) under stringent conditions at 68Â° C. in aqueous with 6Ã—sodium chloride-sodium citrate (SSC) or 42Â° C. in 50% formamide with 6Ã—SSC, wherein said nucleic acid encoding an activated form of ATF6 encodes a polypeptide showing an activity for enhancing expression of endoplasmic reticulum chaperone genes without conversion of the polypeptide in the presence of endoplasmic reticulum stress, or the complementary strand thereto.