Patent ID: 9008765
Filing Date: 2015-04-14
Classification: A61K,A61N

Abstract:
1. A method for transdermal iontophoretic delivery of a therapeutic agent to reduce nicotine cravings in a patient from an inhaled form of tobacco use, the method comprising: positioning at least one electrode assembly in electrical communication with the skin of the patient, the at least one electrode assembly including a skin contacting layer and a solution comprising the therapeutic agent, wherein the therapeutic agent passively diffuses into the skin without application of an external force; delivering a dose of a therapeutic agent from the at least one electrode assembly into the skin during a first period using a first current having a polarity and magnitude to repel the therapeutic agent out of the electrode assembly, a therapeutic agent delivery profile during the first period configured to mimic a nicotine delivery profile from the form of tobacco use; retaining the therapeutic agent in the at least one electrode assembly during a second period using a second current having a polarity and magnitude to retain the therapeutic agent in the electrode assembly such that delivery of the therapeutic agent into the skin during the second period is minimized, wherein the first period comprises a delivery period and the second period comprises a non-delivery period, which together comprise a delivery cycle; and delivering subsequent doses of therapeutic agent over subsequent delivery cycles.