Patent ID: 6387915
Filing Date: 2002-05-14
Classification: C07D

Abstract:
A compound of formula (I) whereinR1 is (a) a phenyl group, (b) a 5- or 6-membered heterocyclic group containing one to three heteroatoms each independently selected from the group consisting of N, O and S, said heterocyclic group being optionally fused to a benzo group, (c) CHR6CHR7Ph, or (d) CR6&boxH;CR7Ph, where groups (a), (b), (c) and (d) are optionally each independently substituted with one to three substituents selected from the group consisting of halo, C1-6 alkyl optionally substituted by OH, halogen, NR4R5, OCOR4, CO2R4, CN, O(C1-6 alkyl optionally substituted by one or more halogens), and CO2R4, where R4 and R5 are each independently H or C1-6 alkyl optionally substituted by one or more halo, and R6 and R7 are each independently H or C1-3 alkyl; R2 is aryl1 or het1; and R3 is H, C1-6 alkyl, C(O)R4, CONHaryl1, CONHhet1, aryl1 and het1; where aryl1 is a phenyl or a naphthyl group, said phenyl and said naphthyl groups being optionally substituted with one to three substituents each independently selected from the group consisting of C1-3 alkyl, CF3, halo, C1-3 alkoxy, OCF3, OH, NO2, CN, NR4R5, COR4, CO2R4, CONR4R5, S(O)p(C1-3 alkyl), CH2NR4R5, NR4COR5, COCF3, CH2OH, S(O)pCF3, C(&boxH;NH)NH2, C2-3 alkynyl, C2-3 alkenyl, phenyl and het2, het1 is a 5- to 7-membered fully saturated, partially unsaturated, or fully unsaturated heterocyclic group containing one to three hetero-atoms each independently selected from the group consisting N, O and S, said heterocyclic group being optionally fused to a benzo group and optionally substituted with one to three substituents each independently selected from the group consisting of C1-3 alkyl, CF3, halo, C1-3 alkoxy, (C1-5 alkyl)OH, (C1-5 alkyl)CO2H, CF3O, OH, NO2, CN, NR4R5, COR4, CO2R4, CONR4R5, S(O)p(C1-3 alkyl), CH2NR4R5, NR4COR5, COCF3, CH2OH, S(O)pCF3, C(&boxH;NH)NH2, C2-3 alkynyl, C2-3 alkenyl, phenyl and het2, with the proviso that when R3 is het1, the het1 group is linked to the adjacent O atom by a carbon atom, het2 is a 5- to 7-membered fully saturated, partially unsaturated, or fully unsaturated heterocyclic group containing one to three hetero-atoms each independently selected from the group consisting of N, O and S, and p is0, 1 or 2; or a pharmaceutically acceptable derivative thereof.