Patent ID: 8614103
Filing Date: 2013-12-24
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating, arresting, or causing regression of a sphingosine-1-phosphate (S1P) related ocular disease or disorder, comprising delivering to a tissue of a target eye of a subject in need of treatment to relieve clinical symptoms of an SIP-related ocular disease or disorder an amount of a composition effective to treat, arrest, or cause regression of the ocular disease or disorder, thereby treating, arresting, or causing the regression of the ocular disease or disorder in the target eye, wherein: (i) the composition comprises an anti-S1P antibody or an antigen binding anti-S1P antibody fragment that comprises at least one heavy chain variable domain and at least one light chain variable domain, wherein each heavy chain variable domain comprises a first sequence of amino acid residues of sequence DHTIH (SEQ ID NO: 13), a second sequence of amino acid residues of sequence AISPRHDITKYNEMFRG (SEQ ID NO: 31), and (iii) a third sequence of amino acid residues of sequence GGFYGSTIWFDF (SEQ ID NO: 15), and wherein each light chain variable domain comprises a first sequence of amino acid residues of sequence ITTTDIDDDMN (SEQ ID NO: 10), a second sequence of amino acid residues of sequence EGNILRP (SEQ ID NO: 11) and a third sequence of amino acid residues of sequence LQSDNLPFT (SEQ ID NO: 12); and (ii) the ocular disease or disorder is selected from the group consisting of age-related macular degeneration, choroidal neovascularization, and diabetic retinopathy.