Patent ID: 6274596
Filing Date: 2001-08-14
Classification: A61K,Y02A

Abstract:
A pharmaceutical composition comprising a compound of formula (II): ##STR26##wherein:R.sub.1, R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alkyl, alkoxy or acyl;X is selected from the group consisting of O, S, CH.sub.2, CH.sub.2 -CH.sub.2, C.dbd.O or NR.sub.B ; provided that when X is NR.sub.B, then(a) R.sub.B is hydrogen, and R.sub.A is a linear or branched chain lower alkyl, aryl, heteroaryl or cycloalkyl optionally interrupted by at least one heteroatom, said alkyl, aryl, heteroaryl or cycloalkyl being optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, acyl, alkoxy, or cycloalkyl optionally interrupted by at least one heteroatom and optionally substituted by at least one linear or branched chain lower alkyl, acyl, or alkoxy, or a linear or branched chain lower alkyl mono- or dialkylamino wherein said linear or branched chain lower alkyl mono- or dialkylamino is not ethyl or diethylamino, (linear or branched chain lower alkyl N-mono- or N,N-dialkylamino) (lower alkyl), (linear or branched chain lower alkyl N-mono- or N,N-dialkyl)carbamyl, aryl or heteroaryl, said aryl or heteroaryl being optionally substituted by at least one alkyl, alkenyl, or alkynyl, wherein said alkyl, alkenyl or alkynyl is optionally substituted by at least one hydroxy;or(b) X, R.sub.A and R.sub.B together form a ring system comprising from about five to about twelve linked carbon atoms, said system being optionally interrupted by at least one heteroatom, optionally mono- or polyunsaturated and optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, acyl, or alkoxy, a linear or branched chain lower alkyl N-mono- or N,N-dialkylamino, (linear or branched chain lower alkyl N-mono- or N,N-dialkylamino)(lower alkyl), halogen, cyano, trifluoromethyl, nitro or aryl or heteroaryl; andwhen X is O, S, CH.sub.2, CH.sub.2 -CH.sub.2 or C.dbd.O, then(a) R.sub.A is hydrogen or a linear or branched chain lower alkyl, aryl or heteroaryl, said alkyl, aryl or heteroaryl being optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, acyl, or alkoxy, a linear or branched chain lower alkyl N-mono- or N,N-dialkylamino, (linear or branched chain lower alkyl N-mono- or N,N-dialkylamino) (lower alkyl), halogen, cyano, trifluoromethyl, nitro or aryl or heteroaryl; and(b) R.sub.3 is a linear or branched chain lower alkyl substituted by hydroxyphenyl, or is a linear or branched chain lower alkoxyphenyl singly or plurally substituted by CH.sub.2 NR.sub.C R.sub.D wherein N, R.sub.C and R.sub.D together form a ring system comprising from about five to about twelve linked carbon atoms, said system being optionally interrupted by at least one heteroatom, optionally mono- or polyunsaturated and optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, acyl, or alkoxy, a linear or branched chain lower alkyl N-mono- or N,N-dialkylamino, (linear or branched chain lower alkyl N-mono- or N,N-dialkylamino)(lower alkyl), halogen, cyano, trifluoromethyl, nitro, or aryl or heteroaryl;or a salt thereof, and a pharmaceutically acceptable carrier or diluent.