Patent ID: 6444194
Filing Date: 2002-09-03
Classification: A61K

Abstract:
A phototherapeutic compound composed of an atom of In113 or of In115 complexed with the inner nitrogens of a pyrrolic core or a phototherapeutic composition consisting essentially of a mixture of In113 and of In115 atoms complexed with the inner nitrogens of a pyrrolic core where, in both instances, the core is composed of at least two pyrroles whose pyrrole linking atoms may be carbon or nitrogen or combinations thereof, with the proviso that indium-monoacetylethylene glycol mono-10b-pheophorbate, indium-di-2,4-(1-ethanalcoholoxyethl)-deuteroporohyrinindium; indium deuteroporphyrin; indium hematoporphyrin; 2-[1-(diethylenetriamine-tetraacetic acidacetyloxyethane)oxyethyl]-4-[1-(2-hydroxyethyl)oxyethyl]In deuteroporphyrin; 2,4-Bis[1-(diethylenetriamine-tetraacetic acidacetyloxyethane)oxyethyl]In deuteroporphyrin; 2-[1-(In-diethylenetriamine-tetracaetic acidacetyloxyethane)oxyethyl]-4-[1-(2-hydroxyethyl)oxyethyl]In-deuteroporphyrin; 2,4-Bis[(1-(In-diethylenetriamine-tetracaetic-acetyloxyethane)oxyethyl]In-deuteroporphyrin; In-Hematoporphinyl diglycine; In-Hematoporphinyl diglutamic acid; In-Diacetylhematoporphinyl diglycine; In-Diacetylhematoporphinyl diglutamic acid; fully unsaturated porphyrins having the structure: where R1 is CH(OR)Me, R is alkyl, R2 is a residue derived by removing H from an amino acid or from diethylenetriaminepentaacetic acid, and M is In; and porphyrin derivatives having the structure where R1 is pyridyl, R2 is a substituted phenyl group and M is indium, are excluded.