Patent ID: 8884062
Filing Date: 2014-11-11
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of the formula ab: wherein the ring A is a phenyl that is substituted with at least one selected from the group consisting of (A) the substituent group α, the substituent group α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, imino, hydroxyimino, lower alkoxyimino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfonyl, cyano, nitro, a carbocyclic group and a heterocyclic group; (B) lower alkyl optionally substituted with one or more substituents selected from the substituent group α, hydroxyimino and lower alkoxyimino; (C) amino lower alkyl substituted with one or more substituents selected from the substituent group α; (D) hydroxyimino lower alkyl; (E) lower alkoxyimino lower alkyl; (F) lower alkenyl optionally substituted with one or more substituents selected from the substituent group α; (G) lower alkynyl optionally substituted with one or more substituents selected from the substituent group α; (H) lower alkoxy optionally substituted with one or more substituents selected from the substituent group α; (I) lower alkoxy lower alkoxy optionally substituted with one or more substituents selected from the substituent group α; (J) lower alkenyloxy optionally substituted with one or more substituents selected from the substituent group α; (K) lower alkoxy lower alkenyloxy optionally substituted with one or more substituents selected from the substituent group α; (L) lower alkynyloxy optionally substituted with one or more substituents selected from the substituent group α; (M) lower alkoxy lower alkynyloxy optionally substituted with one or more substituents selected from the substituent group α; (N) lower alkylthio optionally substituted with one or more substituents selected from the substituent group α; (O) lower alkenylthio optionally substituted with one or more substituents selected from the substituent group α; (P) lower alkynylthio optionally substituted with one or more substituents selected from the substituent group α; (Q) lower alkylamino substituted with one or more substituents selected from the substituent group α; (R) lower alkenylamino substituted with one or more substituents selected from the substituent group α; (S) lower alkynylamino substituted with one or more substituents selected from the substituent group α; (T) aminooxy optionally substituted with one or more substituents selected from lower alkylidene and the substituent group α; (U) acyl substituted with one or more substituents selected from the substituent group α; lower alkylsulfonyl optionally substituted with one or more substituents selected from the substituent group α; (V) lower alkylsulfinyl optionally substituted with one or more substituents selected from the substituent group α; (W) sulfamoyl; (X) lower alkylsulfamoyl optionally substituted with one or more substituents selected from the substituent group α; (Y) a carbocyclic group optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (Z) a heterocyclic group optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AA) carbocyclyl lower alkyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AB) heterocyclyl lower alkyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AC) carbocyclyloxy optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AD) heterocyclyloxy optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AE) carbocyclyl lower alkoxy optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AF) heterocyclyl lower alkoxy optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl, (AG) carbocyclyl lower alkoxycarbonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AH) heterocyclyl lower alkoxycarbonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AI) carbocyclylthio optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AJ) heterocyclylthio optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AK) carbocyclyl amino optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AL) heterocyclyl amino optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AM) carbocyclyl lower alkylamino optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AN) heterocyclyl lower alkylamino optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AO) lower alkylsulfamoyl optionally substituted with one or more substituents selected from the substituent group α; (AP) carbocyclylsulfamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AQ) heterocyclylsulfamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AR) carbocyclylsulfonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AS) heterocyclylsulfonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AT) carbocyclylcarbamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AU) heterocyclyl carbamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AV) carbocyclyl lower alkylcarbamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AW) heterocyclyl lower alkylcarbamoyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl, (AX) carbocyclyloxycarbonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; (AY) heterocyclyloxycarbonyl optionally substituted with one or more substituents selected from the substituent group α, azide, lower alkyl and halogeno lower alkyl; lower alkylenedioxy optionally substituted with halogen; (AZ) oxo; (BA) azide; and (BB) one of the following formulae: wherein Ak Ak W W R R the ring B is a carbocyclic group or a heterocyclic group, the carbocyclic group and the heterocyclic group being substituted optionally with at least one selected from the above (A) to (BA); p is 1 or 2; W R R R wherein acyl includes aliphatic acyl, carbocyclyl carbonyl and heterocyclyl carbonyl, and the substituent(s) is selected from the substituent group α, and the substituent(s) for a moiety of the ring in carbocyclyl carbonyl and heterocyclylcarbonyl is selected from lower alkyl, the substituent group α and lower alkyl substituted with one or more substituents selected from the substituent group α, or a salt thereof.