Patent ID: 6683201
Filing Date: 2004-01-27
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I) whereinU is O or a lone pair, Y is C or N, V is O, S, NR6, â€”CH2â€”, â€”CH&boxH;CHâ€”, or â€”Câ‰¡Câ€”, if Y is C, or â€”CH2â€”, â€”CH&boxH;CHâ€”, or â€”Câ‰¡Câ€”, if Y is N, W is CO, COO, CONR1, CSO, CSNR1, SO2, or SO2NR1, L is lower-alkylene, lower-alkenylene, or a single bond, A1 is H, lower-alkyl, or lower-alkenyl, A2 is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, or lower-alkinyl, each unsubstituted ot substituted by R2, A3, A4 are hydrogen or lower-alkyl, or A1 and A2 or A1 and A3 are bonded to each other to form a ring and â€”A1â€”A2â€” or â€”A1â€”A3â€” are lower-alkylene or lower-alkenylene, each unsubstituted or substituted by R2, or are lower-alkylene or lower-alkenylene, each unsubstituted or substituted by R2, in which one â€”CH2â€” group of â€”A1â€”A2â€” or â€”A1â€”A3â€” is replaced by NR3, S, or O, A5 is lower-alkyl, X is hydrogen or one or more halogen substituents, A6 is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, heterocycloalkyl-lower-alkyl, lower alkenyl, lower-alkadienyl, aryl, aryl-lower-alkyl, heteroaryl, or heteroaryl-lower-alkyl, R2 is hydroxy, hydroxy-lower-alkyl, lower-alkoxy, N(R4,R5), or lower-alkoxycarbonyl, R1, R3, R4, R5 and R6 independently from each other are hydrogen or lower-alkyl, or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof.