Patent ID: 6214375
Filing Date: 2001-04-10
Classification: A61K,Y02A

Abstract:
A liposomal formulation comprising i) at least one medicinally active ingredient, ii) at least three compounds selected from the group consisting of egg phosphatidylcholine, dilauryl phosphatidylcholine, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, dioleoyl phosphatidylcholine, dimyristoyl phosphatidylglycerol, dipalmitoyl phosphatidic acid, dipalmitoyl phosphatidic acid, dipalmitoyl phosphatidylethanolamine, distearoyl phosphatidylcholine, brain phosphatidylserine, brain sphingomyelin, cholesterol, cardiolipin, trioctanoin, triolein, soy phosphatidylcholine, poly(adenylic acid), phosphatidylethanolamine, phosphatidyl glycerol, phosphatidyl inositol, sphingosine, cerebroside (glycolipid), and iii) at least two biodegradable polymers selected from the group consisting of copolymers of sucrose and epichlorohydrin having molecular weights of from 70 000 to 400 000, branched hydrophilic polymers of sucrose having molecular weights of from 70 000 to 400 000, polyethylene glycols having molecular weights of from 1000 to 100 000, polyvinyl alcohols having molecular weights of from 70 000 to 110 000, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide, polyoxyethylene, polyoxypropylene, cellulose acetate, sodium alginate, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene, polyvinyl pyrrolidone, polyoxyethylene X-lauryl ether wherein X is from 9 to 20, and polyoxyethylene sorbitan esters.