Patent ID: 6809105
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound of formula I or pharmaceutically acceptable salts thereof, whereinA is CH2; B is CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of a covalent bond, CH2, and CH2CH2, provided that when Y is CH2CH2, then Z is a covalent bond and further provided that when Z is CH2CH2, then Y is a covalent bond; R1 is selected from the group consisting of R3 is selected from the group consisting of hydrogen, alkyl, and halogen; R4 is selected from the group consisting of hydrogen, alkoxy, alkyl, amino, halogen, and nitro; R5 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio, alkynyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, 5-tetrazolyl, â€”NR6S(O)2R7, â€”C(NR6)NR7R8, â€”CH2C(NR6)NR7R8, â€”C(NOR6)R7, â€”C(NCN)R6, â€”C(NNR6R7)R8, â€”S(O)2OR6, and â€”S(O)2R6; R6, R7, and R8 are independently selected from the group consisting of hydrogen and alkyl; and R9 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, amino, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, and phenoxycarbonyl.