Patent ID: 6046157
Filing Date: 2000-04-04
Classification: A61K,A61P,C07K

Abstract:
A method of altering TGF-.beta. binding to TGF-.beta. type II receptor on the surface of a cell, comprising combining with the cell a preparation consisting essentially of a soluble polypeptide comprising the amino acid sequence of the extracellular domain of a mammalian TGF-.beta. type II receptor protein, wherein the amino acid sequence of the mammalian receptor protein is:(a) the amino acid sequence of the TGF-.beta. type II receptor protein of SEQ ID NO: 8, or(b) the amino acid sequence of a TGF-.beta. type II receptor protein encoded by mammalian DNA which hybridizes to a probe having the sequence of the complement of SEQ ID NO: 7 under high stringency conditions;wherein the polypeptide and cell are combined under conditions appropriate for binding of the soluble TGF-.beta. type II receptor to TGF-.beta..