Patent ID: 7381718
Filing Date: 2008-06-03
Classification: A61P,C07J,Y02P

Abstract:
1. A process for the preparation of a compound of the formula selected from the group consisting of wherein either R or R R n is an integer from 2 to 8 comprising reacting a compound of the formula K is a protected ketone function with a silylation agent in the presence of a base, to obtain a silylated enol of the formula wherein Ra, Rb and Rc, are individually alkyl of 1 to 4 carbon atoms or phenyl, reacting the said compound of formula III with an organocuprate derivative, derived from the organometallics R n, R to obtain a compound of the formula which is isolated or non-isolated: and then reacted with a deprotection agent to obtain a compound of the formula: and reacting the latter with an aromatization agent to obtain the expected compound of formula (I) and optionally subsequently deprotecting to obtain a compound of formula (I) with R