Patent ID: 8957186
Filing Date: 2015-02-17
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant protein delivering siRNA into the cell, wherein the recombinant protein is formed in a spherical particle via a self-assembly of the subunit proteins where a RGD (Arg-Gly-Asp) peptide is located on the exterior surface of the spherical particle and a Carnation Italian ringspot virus(CIRV)-derived p19 protein is located in the interior cavity of the spherical particle, and wherein the subunit protein is a fusion protein comprising the following peptide: where A is a capsid protein of HBV (Hepatitis B virus) that comprises the residues 1-149 of SEQ ID NO: 1 and the RGD (Arg-Gly-Asp) peptide insertion between the residues 80 and 81 of SEQ ID NO: 1; B is a linker peptide that comprises an amino acid sequence of SEQ ID NO: 4; and C is the CIRV-derived p19 protein that comprises the residues 3-172 of SEQ ID NO: 2 and capable of binding to siRNA.