Patent ID: 6165978
Filing Date: 2000-12-26
Classification: A61K,A61L,A61P,C07K

Abstract:
A composition for accelerating wound healing, comprising a suitable carrier or diluent and an amount effective to accelerate wound healing of at least one compound having at least five contiguous amino acids of a general formula selected from the group consisting of:R.sup.1 -Arg-norLeu-R.sup.3 -R.sup.4 -His-Pro-R.sup.5,R.sup.1 -Arg-R.sup.2 -Tyr(PO.sub.3).sub.2 -R.sup.4 -His-Pro-R.sup.5,R.sup.1 -Arg-R.sup.2 -homoSer-R.sup.4 -His-Pro-R.sup.5, andR.sup.1 -Arg-R.sup.2 -R.sup.3 -norLeu-His-Pro-R.sup.5,wherein R.sup.1 is selected from the group consisting of H and Asp;R.sup.2 is selected from the group consisting of Val and norLeu;R.sup.3 is selected from the group consisting of Tyr, Tyr(PO.sub.3).sub.2 and homoSer;R.sup.4 is selected from the group consisting of Ile and norLeu; andR.sup.5 is selected from the group consisting of H, Phe and Ile; andwherein when the general formula isR.sup.1 -Arg-R.sup.2 -Tyr(PO.sub.3).sub.2 -R.sup.4 -His-Pro-R.sup.5,at least one of the following is true, R.sup.1 is H;R.sup.2 is norLeu; andR.sup.5 is selected from the group consisting of H and Ile; andwherein when the general formula isR.sup.1 -Arg-R.sup.2 -R.sup.3 -norLeu-His-Pro-R.sup.5,at least one of the following is true, R.sup.1 is H;R.sup.2 is norLeu;R.sup.3 is homoSer; andR.sup.5 is selected from the group consisting of H and Ile.