Patent ID: 6156878
Filing Date: 2000-12-05
Classification: A61K,A61P,C07K

Abstract:
An isolated ACT-4 receptor polypeptide comprising an amino acid sequence selected from the group consisting of:(a) variants of the amino acid sequence of the ACT-4-h-1 receptor polypeptide shown in FIG. 5 (SEQ ID NO:2) having at least one conservative amino acid substitution; and(b) variants of the amino acid sequence of the ACT-4-h-1 receptor polypeptide shown in FIG. 5 (SEQ ID NO:2) which are encoded by a nucleic acid that hybridizes under stringent conditions to a nucleic acid encoding the amino acid sequence of the ACT-4-h-1 receptor polypeptide shown in FIG. 5 (SEQ ID NO:2),said isolated ACT-4 receptor polypeptides of (a) and (b) having the ability to bind specifically to the ACT-4-L-h-1 ligand having the amino acid sequence shown in FIG. 10 (SEQ ID NO:4).