Patent ID: 6911496
Filing Date: 2005-06-28
Classification: A61L,C08B,C08G,C08H,C08L,Y10S

Abstract:
1. A method for preparing a positively charged compound-containing matrix useful for delivery of a positively charged compound to a mammalian subject, comprising: (a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧2; (b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n≧5; (c) admixing the first and second crosslinkable components in a basic, aqueous medium to initiate crosslinking and form a crosslinked matrix with an excess of negatively charged electrophilic groups; and (d) contacting the negatively charged crosslinked matrix with the positively charged compound to allow ionic binding therebetween, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic.