Patent ID: 6627626
Filing Date: 2003-09-30
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof;wherein m is 0, 1 or 3; n is 1,2, or 3; wherein ring W is connected to the pyrazole ring through a nitrogen atom and is a radical selected from the group consisting of: a) a saturated, partially saturated or aromatic (3â€” to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of â€”N&boxH;, â€”NHâ€”, â€”Oâ€”, and â€”Sâ€”; b) a saturated, partially saturated or aromatic (3â€” to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of â€”N&boxH;, â€”NHâ€”, â€”Oâ€”, and â€”Sâ€”; wherein said saturated, partially saturated or aromatic (3â€” to 7-membered)-heterocyclyl is fused to a a saturated, partially saturated or aromatic (3â€” to 7-membered)-carbocyclic ring; and c) a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of â€”N&boxH;, â€”NHâ€”, â€”Oâ€”, and â€”Sâ€”; wherein said saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl is fused to a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NHâ€”, â€”Sâ€” and â€”Oâ€”; R1 is a radical selected from the group consisting of H, â€”NO2, â€”CN, (C1-C6)alkyl, (C1-C6)alkyl-SO2â€”, (C6-C10)aryl-SO2â€”, Hâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, (C1-C9)heteroaryl-(C&boxH;O)â€”, (C1-C9)heterocyclyl-(C&boxH;O)â€”, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2-Nâ€”(C&boxH;O)â€”, [(C6-C10)aryl]-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]-(C&boxH;O)â€”, HOâ€”NHâ€”(C&boxH;O)â€”, and (C1-C6)alkyl-Oâ€”NHâ€”(C&boxH;O)â€”; R2 is a radical selected from the group consisting of H, â€”NO2, â€”CN, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocyclyl, (C1-C6)alkyl-Oâ€”, (C3-C7)cycloalkyl-(C&boxH;O)â€”, (C6-C10)aryl-(C&boxH;O)â€”, (C1-C9)heteroaryl-(C&boxH;O)â€”, (C1-C9)heterocyclyl-Oâ€”, Hâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”, (C3-C7)cycloalkyl-(C&boxH;O)â€”, (C6-C10)aryl-(C&boxH;O)â€”, (C1-C9)heteroaryl-(C&boxH;O)â€”, (C1-C9)heterocyclyl-(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, (C3-C7)cycloalkyl-Oâ€”(C&boxH;O)â€”, (C6-C10)aryl-Oâ€”(C&boxH;O)â€”, (C1-C9)heteroaryl-Oâ€”(C&boxH;O)â€”, (C1-C9)heterocyclyl-Oâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C3-C7)cycloalkyl-(C&boxH;O)â€”Oâ€”, (C6-C10)aryl-(C&boxH;O)â€”Oâ€”, (C1-C9)heteroaryl-(C&boxH;O)â€”Oâ€”, (C1-C9)heterocyclyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”NHâ€”, (C3-C7)cycloalkyl-(C&boxH;O)â€”NHâ€”, (C6-C10)aryl-(C&boxH;O)â€”NHâ€”, (C1-C9)heteroaryl-(C&boxH;O)â€”NHâ€”, (C1-C9)heterocyclyl-(C&boxH;O)â€”NHâ€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”NHâ€”, (C1-C6)alkyl-NH, [(C1-C6)alkyl]2-Nâ€”, (C3-C7)cycloalkyl-NHâ€”, [(C3-C7)cycloalkyl]2-Nâ€”, [(C6-C10)aryl]-NHâ€”, [(C6-C10)aryl]2-Nâ€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]â€”, [(C1-C9)heteroaryl]-NHâ€”, [(C1-C9)heteroaryl]2-Nâ€”, [(C1-C9)heterocyclyl]-NHâ€”, [(C1-C9)heterocyclyl]2-Nâ€”, H2Nâ€”(C&boxH;O)â€”, HOâ€”NHâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2-Nâ€”(C&boxH;O)â€”, [(C3-C7)cycloalkyl]-NHâ€”(C&boxH;O)â€”, [(C3-C7)cycloalkyl]2-Nâ€”(C&boxH;O)â€”, [(C6-C10)aryl]-NHâ€”(C&boxH;O)â€”, [(C6-C10)aryl]2-Nâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]-(C&boxH;O)â€”, [(C1-C9)heteroaryl]-NHâ€”(C&boxH;O)â€”, [(C1-C9)heteroaryl]2-Nâ€”(C&boxH;O)â€”, [(C1-C9)heterocyclyl]-NHâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Sâ€” and (C1-C6)alkyl optionally substituted by one â€”OH group or by one to four fluoro substituents; Each R3is a radical independently selected from the group consisting of H, halo, â€”OH, â€”CN, â€”NO2, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, (C6-C10)aryl, (C2-C9)heterocyclyl, (C1-C6)alkyl-Oâ€”, Hâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, â€”NH2, (C1-C6)alkyl-NHâ€”, [(C1-C6)alkyl]2-Nâ€”, (C3-C7)cycloalkyl-NHâ€”, (C6-C10)aryl-NHâ€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]â€”, (C1-C9)heteroaryl-NHâ€”, H2Nâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2-Nâ€”(C&boxH;O)â€”, [(C6-C10)aryl]-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]â€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”NHâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”HNâ€”, (C1-C6)alkyl-(C&boxH;O)â€”[(C1-C6)alkyl-N]â€”, â€”SH, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, and (C1-C6)alkyl optionally substituted with one to four fluoro substituents; R4 is an (C1-C6)alkyl radical, wherein said (C1-C6)alkyl radical may optionally be substituted by one to four fluoro substituents; R5 is a radical selected from the group consisting of H, halo, â€”OH, (C1-C6)alkyl-(C&boxH;O)â€”, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, â€”CN, Hâ€”(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”, [(C1-C6)alkyl]2-Nâ€”, (C3-C7)cycloalkyl-NHâ€”, (C6-C10)aryl-NHâ€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]â€”, (C1-C9)heteroaryl-NHâ€”, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2-Nâ€”(C&boxH;O)â€”, (C6-C10)aryl-(C&boxH;O)â€”, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]â€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”NHâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Sâ€”, and (C1-C6)alkyl optionally substituted with one to four fluoro substituents.