Patent ID: 6403646
Filing Date: 2002-06-11
Classification: A61K

Abstract:
A method for treating alpha-1-antitrypsin deficiency comprising administering to a vertebrate animal with alpha-1-antitrypsin deficiency an alpha-1-antitrypsin secretion stimulating amount of a compound of formula I: whereinR0 is an aryl, phenoxy, substituted aryl or substituted phenoxy wherein the substituents are selected from the group consisting of halogen, lower alkyl and hydroxy; R1, R2, R3, and R4 are, independently, H, a lower alkoxy, a lower straight or branched chain alkyl, or a halogen; and n is an integer from 0 to 2; or a pharmaceutically acceptable salt or ester of a compound of formula I; or a mixture of compounds of formula I; or a mixture of pharmaceutically acceptable salts of formula I.