Patent ID: 7105671
Filing Date: 2006-09-12
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula: wherein R 1 and R 2 are independently hydrogen, halo, amino, hydroxyamino, cyano, nitro, lower alkyl, —OR 5 , perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or sulfonamido; R or an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; said mono-substituted heteroaromatic ring being mono-substituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, perfluoro-lower alkyl, amidooxime, n is 0, 1, 2, 3 or 4; R * denotes a carbon atom that is asymmetric in all or most of the compounds of formula I; or a pharmaceutically acceptable salt thereof.