Patent ID: 9056102
Filing Date: 2015-06-16
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A soluble fusion protein which binds to a death receptor and induces apoptosis, the fusion protein comprising: (i) a soluble vascular endothelial growth factor receptor-1 (VEGFR-1) polypeptide that binds a vascular endothelial growth factor (VEGF) polypeptide, wherein the VEGFR-1 polypeptide comprises an amino acid sequence at least 95% identical to amino acid residues 129 to 230 of SEQ ID NO: 19; and (ii) a soluble human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) extracellular domain, wherein the C-terminus of the VEGFR-1 polypeptide is linked to the N-terminus of the TRAIL extracellular domain.