Patent ID: 7288658
Filing Date: 2007-10-30
Classification: C07D

Abstract:
1. A process for the manufacture of a compound of formula wherein R R each R 3 is independently hydrogen, C 3 - 6 -cycloalkyl, benzyl or lower alkyl; R wherein the process comprises the steps of a) reacting a compound of formula with a compound of formula wherein R 1 and R 1′ are as defined above, to a compound of formula wherein the substituents are as defined above; b) converting the OH/═O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group selected from the group consisting of POCl wherein P is halogen or trifluoromethanesulfonate and R 1 and R 1′ are as defined above; c) substituting the leaving group P with the group R wherein R 1 and R 1′ and R 2 are as defined above; and d) hydrolyzing the nitrile function of compound XVI in an acidic medium comprising H wherein the definition of the substituents is given above.