Patent ID: 8324186
Filing Date: 2012-12-04
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) X is H, F, OH, or NH R —O-benzoisothiazol-3-yl, —O-benzoisoxazolyl, —O-benzothiazolyl, —O-benzoxazolyl, —O-benzofuryl, —O-indolyl, —O-benzoimidazolyl, —O-indazolyl, —O-furyl, —O-imidazolyl, —O-oxazolyl, —O-isoxazolyl, —O-thiophenyl, —O-benzothiophenyl, —O-thiazolyl, —O-isothiazolyl, —O-pyridazyl, —O-pyrazolyl, —O-pyrrolyl, —O— benzo[1,3]dioxolyl, —O-pyrimidyl, indazol-1-yl, —O-pyridyl, imidazol-1-yl, pyridon-1-yl, pyrimidon-1-yl, pyrazol-1-yl, indol-1-yl, pyridaz-1-yl, or pyrrol-1-yl; alternatively, both R wherein any R SCH 3 , S(O)CH 3 , SO 2 CH 3 , pyrrolidinyl, OH, NH 2 , NHCN, CO 2 H, CONH 2 , NHCO 2 C (1-4) alkyl, N(SO 2 CH 3 ) 2 , NHSO 2 CH 3 , NHC(O)CF 3 , NHC (1-4) alkyl, NHCO 2 H, NHCO 2 C (1-4) alkyl, NHCOC (1-4) alkyl, NHCONH 2 , NHCONHC (1-4) alkyl, and Br; R R R and tautomers, and pharmaceutically acceptable salts thereof.