Patent ID: 6670380
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A compound of formula I: or enantiomers, diastereomers , pharmaceutically acceptable salts and pro esters thereof whereinA is â€”R1; Q is â€”(CR3R4)nâ€”R2 where a is 1; X is (CR3aR4a)nâ€”Z where a is 0 or 1; R1 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl or cycloalkyl; R2 is aryl, substituted aryl, cycloalkylalkyl, heteroaryl or substituted heteroaryl; R3 and R4 are the same or different and are selected from hydrogen, alkyl an substituted alkyl; R3a and R4a are the same or different and are selected from hydrogen, hydra ,alkyl and substituted alkyl; R9 is H, alkyl, cycloalkyl, aryl, aralkyl, or heteroaryl; Z is CO2R9, CONH2, PO3H2, CONHOH, or tetrazole of the formula: or its tautomer; and n is an integer selected from 0 to 1 where each incidence of n is chosen independently.