Patent ID: 6063774
Filing Date: 2000-05-16
Classification: A61K,C07D

Abstract:
A compound of Formula I ##STR13## wherein a is a ring of 6 to 8 members; n or n' independently is an integer of from 1 to 2;Z is nitrogen;R.sub.1 is hydrogen,alkyl of from 1 to 6 carbon atoms,aralkyl of from 7 to 12 carbon atoms,carboxyalkyl of from 2 to 8 carbon atoms;R.sub.2 is H or oxygen of carbonyl;R.sub.3 is hydrogen,alkyl of from 1 to 6 carbon atoms,alkenyl of from 3 to 6 carbon atoms,cycloalkyl of from 5 to 7 carbon atoms, orhalogen,haloalkyl of from 1 to 6 carbon atoms,aryl of from 6 to 12 carbon atoms,aralkyl of from 7 to 12 carbon atoms,heteroaromatic ring of from 5 to 8 members which contain nitrogen, oxygen or sulfur,heterocyclic ring of from 4 to 7 members which contains nitrogen, oxygen or sulfur,nitro,cyano,SO.sub.2 CF.sub.3,(CH.sub.2).sub.m CO.sub.2 R.sub.8,(CH.sub.2).sub.m CONR.sub.8 R.sub.9,SONR.sub.8 R.sub.9, orNHCOR.sub.8 ;R.sub.4 and R.sub.5 are each independentlyhydrogen,alkyl of from 1 to 6 carbon atoms,cycloalkyl of from 5 to 7 carbon atoms,alkenyl of from 3 to 6 carbon atoms,halogen,haloalkyl of from 1 to 6 carbon atoms,nitro,cyano,SO.sub.2 CF.sub.3,CH.sub.2 SO.sub.2 R.sub.10,(CH.sub.2).sub.m CO.sub.2 R.sub.10,(CH.sub.2).sub.m CONR.sub.11 R.sub.12,(CH.sub.2).sub.m SO.sub.2 NR.sub.11 R.sub.12, orNHCOR.sub.6,wherein m is an integer of from 0 to 4; andR.sub.6 is hydrogen,R.sub.7 is hydrogen,alkyl of from 1 to 6 carbon atoms,aralkyl of from 7 to12 carbon atoms,cycloalkyl of from 5 to 7 carbon atoms,aryl of from 6 to 12 carbon atoms,heteroaromatic ring of from 5 to 8 members containing oxygen, nitrogen or sulfur,heterocyclic of from 4 to 7 members containing oxygen, nitrogen or sulfur, oroxygen of carbonyl group;R.sub.8 and R.sub.9 are each independently hydrogen,alkyl of from 1 to 6 carbon atoms,cycloalkyl of from 5 to 7 carbon atoms,haloalkyl of from 1 to 6 carbon atoms,aralkyl of from 7 to 12 carbon atoms; and; either R.sub.2 or R.sub.7 is an oxygen of carbonyl; andR.sub.10, R.sub.11 and R.sub.12 are each independently selected fromhydrogen,alkyl of from 1 to 6 carbon atoms,cycloalkyl of from 5 to 7 carbon atoms,haloalkyl of from 1 to 6 carbon atoms, oraralkyl of from 7 to 12 cabon atoms;or a pharmaceutical salt thereof.