Patent ID: 9150630
Filing Date: 2015-10-06
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a disease or condition by blocking the binding of inhibitor of dishevelled and bone formation (Idbf) to dishevelled (Dvl), thereby activating signal transduction carried out through the Wnt/β-catenin signaling pathway, comprising administering an effective amount of an Idbf inhibitor to a subject in need thereof, wherein the Idbf inhibitor is a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 4 (RKTGHQICKFRKC) or a conjugate of SEQ ID NO: 4 with a protein transduction domain (PTD) of 8-20 amino acids; and wherein the disease or condition is osteoporosis, insufficient bone growth, bone fracture, or insufficient bone density.