Patent ID: 7981999
Filing Date: 2011-07-19
Classification: A61P,C07C,C07K

Abstract:
1. A peptidomimetic macrocycle of Formula (I): wherein: each A, C, D, and E is independently a natural or non-natural amino acid; B is a natural or non-natural amino acid, amino acid analog, [—NH-L 3 -CO—], [—NH-L 3 -SO 2 —], or [—NH-L 3 -]; R R L is a macrocycle-forming linker of the formula L each R each K is O, S, SO, SO each R each R R R v is an integer from 1-1000; w is an integer from 1-1000; x is an integer from 0-10; y is an integer from 0-10; z is an integer from 0-10; and n is an integer from 1-5; wherein the peptidomimetic macrocycle comprises an α-helix or beta sheet.