Patent ID: 7390909
Filing Date: 2008-06-24
Classification: A23L,C07C,C07D

Abstract:
1. A process of producing an optically active monatin represented by the following formula (8) or a salt thereof: wherein each * denotes, independently, an asymmetric center in the R- or S-configuration, wherein the reaction temperature of the process is set within a range of about 0 to 60° C., comprising: wherein R the bond marked with wavey line denotes that carbon atom to which it is attached may be in the R-configuration or the S-configuration, with an optically active amine represented by the formula (10): wherein R * denotes an asymmetric center in the R-configuration or S-configuration, to form a diastereomer salt, and separating the diastereomer salt by crystallization, to obtain an optically active glutaric acid compound salt represented by the formula (11): wherein R R (b) dissociating the optically active glutaric acid compound salt represented by the formula (11) or exchanging the optically active glutaric acid compound salt with a different salt, to prepare an optically active glutaric acid compound represented by the formula (12) or a salt thereof (excluding the optically active glutaric acid compound salt represented by the formula (11)): wherein R to produce a monatin represented by the formula (13) or a salt thereof: wherein