Patent ID: 6309541
Filing Date: 2001-10-30
Classification: B01D,B01J,G01N

Abstract:
A multiple channel, high throughput supercritical fluid chromatographic purification system for substantially simultaneously purifying multiple samples from a chemical library, each of the samples being separable into first and second components comprising:a sample analyzer that analyzes selected sample characteristics;a first purification channel coupled to the sample analyzer, the first purification channel including;a first chromatographic sample separation device positioned to separate a first sample flow into first and second sample components;a first detector positioned to detect the first and second components in the first sample flow;a first flow diverting device moveable to direct a sampling of the first sample component to the analyzer and the remainder of the first sample portion flows along a first flow path away from the diverting first flow device;a first collector positioned to receive at least a portion of the first or second sample component of the first sample the sample analyzer identified as having selected sample characteristics;a second collector positioned to receive remaining components of the first sample not having the selected sample characteristics; anda second purification channel coupled to the sample analyzer, the second purification channel including:a second chromatographic separation device positioned to receive a second sample flow for separation into the first and second components of the second sample flow;a second detector positioned to detect the first and second components of the second sample flow;a second flow diverting device moveable to direct a sampling of the first or second components to the analyzer and a remainder of the second sample portion flows along a second flow path away from the flow diverting device;a third collector positioned to receive at least a portion of the first or second sample components of the second sample having the selected sample characteristics; anda fourth collector positioned to receive remaining components of the second sample not having the selected sample characteristics.