Patent ID: 9023821
Filing Date: 2015-05-05
Classification: A61P,C12N,C12Q

Abstract:
1. A method for the treatment of a disorder associated with a dysfunction of the cilia of a ciliated epithelial tissue, the method comprising the step of administering to a subject in need thereof a miRNA selected from the group consisting of hsa-miR-34a (SEQ ID NO: 38), hsa-miR-34b (SEQ ID NO: 39), hsa-miR-34c-5p (SEQ ID NO: 40), hsa-miR-449a (SEQ ID NO: 46), hsa-miR-449b (SEQ ID NO: 47), and hsa-miR-449c (SEQ ID NO: 201), wherein the disorder is selected from the group consisting of primary ciliopathies, situs invertus, male and female infertility, Alstrom syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, retinal degeneration, Senior-Løken syndrome or secondary ciliopathies, chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, and respiratory infections of viral origin.