Patent ID: 7670788
Filing Date: 2010-03-02
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An anti-BoNT immunoapheresis method of treating immunoresistance to a botulinum toxin therapy in an individual, the method comprising the steps of: a) contacting an anti-BoNT antibody containing component from the individual extracorporeally with a BoNT/B peptide immunosorbent under conditions suitable for the selective binding of the BoNT/B peptide to a neutralizing anti-BoNT antibody, the BoNT/B peptide having a length of at most 60 consecutive amino acid of SEQ ID NO:1 and comprising amino acids 974-992 of SEQ ID NO: 1; and b) returning the neutralizing anti-BoNT antibody depleted component back into the individual.