Patent ID: 7842816
Filing Date: 2010-11-30
Classification: A61P,C04B,C07D,C07F

Abstract:
1. An amino acid prodrug of a compound of the formula and pharmaceutically accepted salts thereof, wherein: R R or R R′, R″ and R′″ independently are selected from hydrogen, lower alkyl, lower alkenyl, aryl and arylalkyl; R″″ is selected from alkyl, lower alkenyl, aryl and arylalkyl; or any two of R′, R″, R′″ or R″″ together with the atom to which they are attached form a 4 to 10 membered heteroaryl or heterocyclic ring, each of which is optionally substituted with one to three groups independently selected from halogen, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl; R R R R W is selected from heteroaryl, heterocyclyl, —C(O)OR R R m is 0, 1, 2, 3, 4 or 5; and j is 1 or 2.