Patent ID: 7629128
Filing Date: 2009-12-08
Classification: A61K,C07F,G01N

Abstract:
1. A method of identifying an individual susceptible to treatment with a HIF-1α inhibitor comprising: obtaining a blood sample from said individual; isolating peripheral blood mononuclear cells (PBMCs) from said blood sample; exposing said PBMCs to a leukocyte stimulating agent selected from phorbol myristate acetate, calcium ionophore, lipopolysaccharide and combinations thereof; measuring a level of HIF-1α protein in said PBMCs ; and identifying said individual susceptible to treatment, wherein elevated levels of HIF-1α protein in stimulated PBMCs compared to unstimulated PBMCs indicate said individual's susceptibility to said treatment with said HIF-1α inhibitor.