Patent ID: 6380223
Filing Date: 2002-04-30
Classification: A61P,C07C,C07D

Abstract:
A compound of formula II an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug;whereinR1 is -phenyl substituted with zero or one of the following: â€”OH, â€”NR12R13, â€”NR12â€”C(O)â€”(C1-C4)alkyl, â€”CN, â€”(C0-C2)alkyl-het, â€”Oâ€”(C1-C3)alkyl-C(O)â€”NR12R13, â€”NR12â€”(C0-C2)alkyl-C(O)â€”NR12R13, â€”(C0-C2)alkyl-NR12â€”SO2â€”R13, â€”NR12â€”SO2â€”het, â€”Oâ€”C(O)â€”(C1-C4)alkyl or â€”Oâ€”SO2â€”(C1-C4)alkyl; R2 is â€”OH; R3 is a) â€”(C1-C6)alkyl substituted with 0 or 1 of the following: â€”CF3, â€”CN, â€”(C3-C6)cycloalkyl, -phenyl or â€”N3, b) â€”Câ‰¡Câ€” substituted with 1 of the following: â€”(C1-C5)alkyl, â€”Cl, â€”CF3, â€”(C3-C6)cycloalkyl, -phenyl or -benzyl: c) â€”CH2OH, d) â€”CH2O(C1-C5)alkyl wherein 1 carbon atom, other than the connecting carbon atom, may optionally be replaced with 1 oxygen atom, e) â€”CH2O(C2-C5)alkenyl, f) â€”CH2O(C2-C5)alkynyl wherein 1 carbon atom, other than the connecting carbon atom, may optionally be replaced with 1 oxygen atom, g) â€”CH2ORy, h) â€”CN or i) â€”CF3; whereinRy is a) â€”(C1-C3)alkyl-CF3, b) â€”(C3-C6)cycloalkyl, c) -phenyl or d) -benzyl; R10 is â€”C(O)â€”NHâ€”Zâ€”het; het is a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring containing from one (1) to three (3) heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur; and substituted with 0 to 3 Rx; Rx for each occurrence is independently a) -halo, b) â€”OH, c) â€”(C1-C8)alkyl, d) â€”(C2-C6)alkenyl, e) â€”(C2-C6)alkynyl, f) â€”O(C1-C6)alkyl, g) â€”O(C2-C6)alkenyl, h) â€”O(C2-C6)alkynyl, i) â€”(C0-C6)alkyl-NR12R13, j) â€”C(O)â€”NR12R13, k) â€”(C0-C2)alkyl-SO2R12, l) â€”(C0-C2)alkyl-SOR12, m) â€”(C0-C2)alkyl-SR12, n) â€”NR12â€”SO2R13, o) â€”NR12â€”C(O)â€”R13, p) â€”NR12â€”OR13, q) â€”SO2â€”NR12R13, r) â€”CN, s) â€”CF3, t) â€”C(O)(C1-C6)alkyl, u) &boxH;O or v) â€”(C0-C2)alkyl-SO2-phenyl; Z is â€”(C1-C2)alkyl; R12 and R13 are independently a) â€”H or b) â€”(C1-C4)alkyl.