Patent ID: 6528653
Filing Date: 2003-03-04
Classification: A61P,C07D

Abstract:
A compound of formula or a pharmaceutically acceptable salt thereof, whereinR1 represents a 5- or 6-membered monocyclic aromatic ring containing one or more hetero atoms independently selected from N, S and O, the remaining atoms being carbon, said 5- or 6-membered aromatic ring not being fused or being fused to a benzene ring, said 5- or 6-membered monocyclic aromatic ring and said benzene ring each being unsubstituted or each being independently substituted with one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, aryl, substituted aryl, aryl-lower alkyl, substituted aryl-lower alkyl, aryl-lower alkoxy, substituted aryl-lower alkoxy, halogen, haloalkyl, nitro, hydroxy, cyano, â€”C(O)R7, â€”(CH2)nCO2R8, and â€”(CH2)nCONR7R8; R7 is selected from the group consisting of hydrogen, cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, lower alkyl and lower alkyl that may be mono substituted by cycloalkyl, aryl, substituted aryl or heterocyclyl; R8 is selected from the group consisting of hydrogen, cycloalkyl, heterocyclyl, lower alkyl, and lower alkyl that may be mono substituted by cycloalkyl, aryl, substituted aryl, hydroxy, lower alkoxy, heteroaryl, substituted heteroaryl, heterocyclyl or hydroxy-loweralkoxy, or, when R7 and R8 are both attached to nitrogen, R7 and R8 together with the nitrogen atom to which they are attached represent a 5- or 6-membered heterocycle that does not contain or may contain an additional heteroatom selected from N, S and O and may or may not be substituted by lower alkyl, lower alkoxy or hydroxy-lower alkyl; n is 0-3; R2 is H; R3 is selected from the group consisting of hydrogen, â€”COR4, â€”CONR4R5, â€”CONHOR6, cyano, halogen, â€”CO2R5, â€”SO2NR4R5, â€”OR4, lower alkyl, lower alkyl substituted independently by cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, hydroxy, â€”CONR4R5 or â€”CO2R5, lower alkenyl, and lower alkenyl substituted independently by cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, hydroxy, â€”CONR4R5 or â€”CO2R5; R4 is selected from the group consisting of hydrogen, cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, lower alkyl and lower alkyl that may be mono substituted by cycloalkyl, aryl, substituted aryl or heterocyclyl; R5 is selected from the group consisting of hydrogen, cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, lower alkyl, and lower alkyl substituted independently by â€”CONH2, cycloalkyl, aryl, substituted aryl, aryloxy, substituted aryloxy, hydroxy, lower alkoxy, heteroaryl, substituted heteroaryl, heterocyclyl, hydroxy-loweralkoxy or â€”NRâ€²Râ€³ wherein Râ€² is hydrogen, lower alkyl, or lower alkyl substituted by aryl or substituted aryl and Râ€³ is â€”COCH3, lower alkyl, aryl or substituted aryl; â€ƒor alternatively, when R4 and R5 are both attached to nitrogen, R4 and R5 together with the nitrogen atom to which they are attached represent a 5- or 6-membered heterocycle that does not contain or may contain an additional heteroatom selected from N, S and O and may or may not be independently substituted at one or more carbon and/or N-atoms by lower alkyl, lower alkoxy or hydroxy-lower alkyl; and R6 represents hydrogen or heterocyclyl.