Patent ID: 7504500
Filing Date: 2009-03-17
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of formula I in which R is Hal or C≡CH, R R R A is unbranched, branched or cyclic alkyl having 1-10 carbon atoms, in which 1-7 H atoms are optionally replaced by F, Hal is F, Cl, Br or I, or a pharmaceutically acceptable salt, mono- or dihydrate, alcoholate or stereoisomer thereof, comprising a) reacting a compound of formula II  in which R with a compound of formula III  in which R is as defined above, to give a compound of formula IV  in which R and R b) then reacting the compound of formula IV with a compound of formula V  in which R to give a compound of formula I, and c) optionally converting the compound of formula I into a pharmaceutically acceptable salt, mono- or dihydrate or alcoholate thereof by converting a base or acid of the compound of formula I into one of its salts, or by bringing together the compound of formula I with water or an alcohol.