Patent ID: 6852880
Filing Date: 2005-02-08
Classification: C07C,Y02P

Abstract:
1. A process for preparing a compound of the following formula (1): in which R X represents CH R′ represents C which comprises the first step wherein an alkyl halide containing 15S-alcohol of the following formula (3): in which X and R′ are defined as above, Y represents a leaving group, and R″ represents a hydroxy-protecting group, is converted into a cuprate thereof and the cuprate compound is subjected to a stereoselective 1,4-addition reaction to an α,β-unsaturated ketone compound of the following formula (2): in which R R to give a compound of the following formula (4): in which X, R′, R″, R the second step wherein the ketone group on the cyclopentanone ring of the compound of formula (4) is reduced using a metal hydride to give an α-alcohol compound of the following formula (5): in which X, R′, R″, R and the third step wherein the alcohol protecting groups on the cyclopentanone ring and ω-chain in the compound of formula (5) are removed to give the compound of formula (1).