Patent ID: 8039444
Filing Date: 2011-10-18
Classification: A61K,A61P,C12N

Abstract:
1. A pharmaceutical composition comprising: (a) an antisense compound; (b) a branched chain permeation enhancer comprising an acid functional group-containing compound of Formula I in which at least about 50% of the total number of acid functional groups present have been reacted with a base, the compound of Formula I comprising: wherein: Q is selected from the group consisting of a —COOH functional group, a —SO R (c) a pharmaceutically acceptable vehicle, wherein said antisense compound and permeation enhancer are combined in a composition formulated for transdermal administration or transmucosal administration, and wherein the permeation enhancer is present in an amount sufficient to increase the bioavailability of the antisense compound upon transdermal administration or transmucosal administration of the composition to a patient.