Patent ID: 6239110
Filing Date: 2001-05-29
Classification: A61K,C07K,Y02A

Abstract:
A method for promoting or inhibiting thrombospondin-like activity in a patient comprising administering to the patient an effective amount of a polypeptide compound comprising the formula:R.sub.1 -Cys-X.sub.2 -X.sub.3 -X.sub.4 -Cys-R.sub.2 (SEQ ID NO: 1)wherein:X.sub.2, X.sub.3, and X.sub.4 are the same or different amino acid residues selected from the group consisting of valine, threonine, serine, and arginine;R.sub.1 is a protected or unprotected terminal amino group, consisting of hydrogen, amino, acetyl or one amino acid residue or the desamino form thereof; andR.sub.2 is a protected or unprotected terminal carboxyl group consisting of hydroxyl, carboxyl, or one amino acid residue selected from the group consisting of lysine, glycine, and arginine, including, carboxyamide or alkylamide forms thereof;the structure of the polypeptide is optionally cyclized through a bond between the cysteines or a bond between R.sub.1 and R.sub.2.