Patent ID: 8030291
Filing Date: 2011-10-04
Classification: A61P,C12N

Abstract:
1. A method of treating Ebola virus infection in a subject, comprising: administering to a subject a therapeutically effective amount of an antisense oligomer of 12-40 morpholino subunits linked by phosphorous-containing intersubunit linkages which join a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, wherein at least 2 and no more than half of the total number of intersubunit linkages are positively charged at physiological pH; and comprising a targeting sequence which forms a heteroduplex with a target sequence of the AUG start-site region of a positive-strand mRNA for Ebola viral protein 24 (VP24); wherein the antisense oligomer inhibits virus production.