Patent ID: 8834929
Filing Date: 2014-09-16
Classification: A61K,A61P

Abstract:
1. A process for producing pharmaceutical composition comprising: (a) spraying a mixture comprising a drug, an excipient and a solvent and performing a first solvent removing step to form at least partially non-crystalline, dry drug-containing particles, wherein said dry drug-containing particles contain less than about 10 wt % of said solvent; and (b) performing a second solvent removing step by wherein the amount of mobility-enhancing agent present in said chamber is such that during the second solvent removing step said dry particles have a glass transition temperature that is less than the glass transition temperature of such particles free of said solvent and said mobility-enhancing agent, but greater than the temperature at which said second solvent removing step is performed and wherein the amount of solvent remaining in said particles after performing the second solvent removing step is less than about 0.5 wt % of the total mass of said particles.