Patent ID: 6881423
Filing Date: 2005-04-19
Classification: A61K,A61P

Abstract:
1. A powdery composition for nasal administration comprising (i) a drug, (ii) one or more of a water-absorbing and gel-forming base material selected from the group consisting of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, hydroxyethyl cellulose, and sodium carboxymethyl cellulose and (iii) one or more of a water-absorbing and water-insoluble base material selected from the group consisting of crystalline cellulose, α-cellulose, cross-linked sodium carboxy-methyl cellulose, cross-linked starch, chitin and chitosan, wherein the content of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and water-insoluble base material and the water-absorbing and gel-forming base material, 70 wt % or more based on the drug is dispersed on or in the water-absorbing and water-insoluble base material and on or in the water-absorbing and gel-forming base material, the water-absorbing and water-insoluble base material and water-absorbing and gel-forming base material comprise particles, wherein the drug is dispersed more on or in the water-absorbing and water-insoluble base material than on or in the water-absorbing and gel-forming base material, and wherein the powdery composition is obtained by a method comprising adhering the drug to the water-absorbing and water-insoluble base material by freeze drying, then, pulverizing and sieving the water-absorbing and water-insoluble base material with the adhered drug to obtain a resultant water-absorbing and water-insoluble base material comprising water-absorbing and water-insoluble particles, wherein at least 90 wt % based on the resultant water-absorbing and water-insoluble particles have an average particle diameter in the range of 10-350 μm, and subsequently, mechanically mixing the water-absorbing and gel-forming base material, in which at least 90 wt % based on the water-absorbing and gel-forming particles have an average particle diameter in the range of 10-350 μm, with the resultant water-absorbing and water-insoluble base material.