Patent ID: 7749956
Filing Date: 2010-07-06
Classification: A61K

Abstract:
1. A method of treating a mammal with an adiponectin mediated disorder comprising administering a composition comprising a therapeutically effective amount of an adiponectin variant polypeptide relative to human adiponectin as set forth in SEQ ID NO:1 comprising: an amino acid substitution at position 184 selected from the group consisting of E, H, R and T, wherein said adiponectin variant does not comprise residues 1-100 of human adiponectin (SEQ ID NO:1), wherein said adiponectin variant differs by one, two or three amino acids from the amino acid sequence of residues 110-244 of SEQ ID NO:1, and wherein the solubility in aqueous media of said variant is improved relative to the solubililty of a protein consisting of residues 110-224 of SEQ ID NO:1 by at least 3-fold.