Patent ID: 6303794
Filing Date: 2001-10-16
Classification: A61K,A61Q

Abstract:
A polyimido compound selected from the group consisting of polysuccinimide compounds represented by Formula (1): ##STR39##polyglutimide compounds represented by Formula (2); ##STR40##and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2);wherein F is a functionalizing moiety that provides functionality to the polyimido compound; W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; wherein W is selected from the group consisting of:(1) aminopolysaccharides represented by the formula, --N(R.sub.1)-polysaccharide, wherein R.sub.1 is hydrogen or lower alkyl and the number of units in the polysaccharide ranges from 1 to about 51;(2) amines containing quaternary ammonium salts represented by the formula, [--N(R.sub.1)(CH.sub.2).sub.n3 N.sup.+ (CH.sub.3).sub.3 ][A.sup.- ], wherein R.sub.1 is hydrogen or lower alkyl, n.sub.3 is an integer from 1 to about 10, and A is a monovalent anion;(3) amines containing alcohols represented by the formula, --N(R.sub.1)(CH.sub.2).sub.n4 OH, wherein R.sub.1 is hydrogen or lower alkyl and n.sub.4 is an integer from 2 to about 10;(4) amines containing polyalkoxylated alcohols represented by the formula, --N(R.sub.1)CH(CH.sub.3)CH.sub.2 --(OCHR.sub.2 CH.sub.2).sub.n5 --OCH.sub.3, wherein R.sub.1 is hydrogen or lower alkyl, R.sub.2 may be hydrogen or methyl, and n.sub.5 is an integer from 0 to about 50;(5) thiols containing alcohols represented by the formula, --S(CH.sub.2).sub.n6 OH, wherein n.sub.6 is an integer ranging from 2 to about 10;(6) alcohols containing ethers represented by the formula, --O(CH.sub.2 CH.sub.2 O).sub.n7 OM, wherein n.sub.7 is an integer ranging from 0 to about 50 and M is an alkyl group containing from 1 to about 30 carbons; and(7) --O.sup.- X.sup.+, where X is selected from the group consisting of H.sup.+, Na.sup.+, Li.sup.+, NH.sub.4.sup.+, NH(CH.sub.3).sub.3.sup.+, NH.sub.3 (CH.sub.2 CH.sub.2 OH).sup.+, NH.sub.2 (CH.sub.2 CH.sub.2 OH).sub.2.sup.+, and NH(CH.sub.2 CH.sub.2 OH).sub.3.sup..+-. ;with the proviso that n.sub.1.apprxeq.n.sub.2 when W is selected from the group consisting of H.sup.+, Na.sup.+, Li.sup.+, NH.sub.4.sup.+, NH(CH.sub.3).sub.3.sup.+, NH.sub.3 (CH.sub.2 CH.sub.2 OH).sup.+, NH.sub.2 (CH.sub.2 CH.sub.2 OH).sub.2.sup.+, and NH(CH.sub.2 CH.sub.2 OH).sub.3.sup..+-. ; the ratio of n.sub.1 :n.sub.2 :n.sub.3 is from about 1:1:98 to about 45:45:10; and the molecular weight of the polyimido compound is from about 300 to about 1,000,000.