Patent ID: 7141561
Filing Date: 2006-11-28
Classification: C07D

Abstract:
1. A compound of formula (I) wherein R is (C R11, R12, R13, R14 and R15 independently are H or (C B is a bond or a linker of one or two radicals selected from the group consisting of (C(R19)(R20)) i is 1, 2 or 3; R19, R20, R21, R22 and R23 independently are H, (C R1, R2, R3, and R4 independently are H, F, Cl, Br, I, OH, CF R24, R25, R26, R27, R28 and R30 independently are H or (C R29, R31,and R32 independently are H, (C W is —(CH n is 2, 3, 4 or 5; R5, R6, R7 and R8 independently are H, F, Cl, Br, I, OH, CF R33 and R34 independently are H or (C R33 and R34 form together with the nitrogen atom to which they are bonded a 5- or 6-membered ring wherein when R33 and R34 form together with the nitrogen to which they are bonded a 6-membered ring, one CH R35, R36, R37 and R39 independently are H or (C R38, R40 and R41 independently are H, (C A is a chain —(C(R42)(R43)) m is 0, 1, 2, 3, 4 or 5; R42, R43, R44 independently are H, (C R9 and R10 independently are H, (C R9 and R10 form together with the nitrogen atom to which they are bonded a 4- to 10-membered mono-, bi- or spirocyclic ring wherein said ring, apart from the nitrogen atom, may optionally contain 0 to 4 additional heteroatoms selected from the group consisting of O, N and S and wherein said ring optionally is substituted by F, Cl, Br, CF R46, R47, R48, R50, R51 and R52 independently are H or (C o is 0, 1, 2, 3, 4, 5 or 6; R45 is OH, CH(aryl) a pharmaceutically acceptable salt of the compound of formula 1.