Patent ID: 6528532
Filing Date: 2003-03-04
Classification: A61K,C07C,C07D

Abstract:
A compound of formula I and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof,wherein n is 3, 4 or 5, wherein Y is O, S, NH or Nâ€”CN, wherein Cx is selected from the group consisting of â€”COOM, â€”COOR5, and â€”CH2OR6 wherein M is selected from the group consisting of alkali metals and alkaline earth metals, wherein R1 is a benzenesulfonyl group of formula II wherein R2 is selected from the group consisting of a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, and a cycloalkylalkyl group having 3 to 6 carbon atoms in the cycloalkyl part thereof and 1 to 3 carbon atoms in the alkyl part thereof, wherein R3 is selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a piperonyl group, a phenyl group, a picolyl group selected from the group consisting of a thiophene group selected from the group consisting of and a benzyl group of formula III wherein R4 is selected from the group consisting of a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon, a piperonyl (i.e. 3,4-methylenedioxybenzyl) group, 1-indanyl, (R)-2-hydroxy-1-indanyl, (S)-2-hydroxy-1-indanyl, 1-isoquinolyl, 2-quinolyl, a group of formula IIIa a picolyl group selected from the group consisting of thiophene group selected from the group consisting of a group selected from the group consisting of wherein R5 is selected from the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms and a branched alkyl group of 3 or 4 carbon atoms, wherein R6 is selected from the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms and a branched alkyl group of 3 or 4 carbon atoms, wherein R7 and R8, same or different, are selected from the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms, a branched alkyl group of 3 or 4 carbon atoms, F, Cl, Br, I, â€”CF3, â€”NO2, â€”NR9R10, â€”NHCOR9, â€”OR9, â€”SR9, â€”COOR9, â€”COR9 and â€”CH2OH, wherein R9 and R10, same or different, are selected from the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms and a branched alkyl group of 3 or 4 carbon atoms, wherein m is 0 or 1, wherein o is 0, 1 or 2, wherein p is 0, 1 or 2.