Patent ID: 6342613
Filing Date: 2002-01-29
Classification: C07D

Abstract:
A process for the synthesis of 5-(&agr;-hydroxyalkyl)benzo[1,3]dioxols, comprising the following steps:a) reacting the 1,2-dihydroxybenzene (pyrocatechin) (I) in a dipolar aprotic solvent at a temperature of between 70Â° C. and 190Â° C., with a compound of formula (II), where R1 is chosen from H, a C1-C3, linear or branched alkyl, and X is chosen from chlorine, fluorine, bromine, iodine, and a C1-C5 linear or branched alkoxy, obtaining the product of formula (III), where R1 has the meanings described above, b) reacting the compound (III) with an aliphatic anhydride of formula (IV) or with an aliphatic acid of formula (V), where R2 is a C1-C19 linear or branched alkyl, in the presence of an acylation catalyst, obtaining a compound of formula (VI), where R1 and R2 have the aforesaid meanings, c) reducing compound (VI), obtaining the 5-(&agr;-hydroxyalkyl)benzo[1,3]dioxol of formula (VII)