Patent ID: 6951848
Filing Date: 2005-10-04
Classification: A61P,C07D

Abstract:
1. A compound having the formula or a physiologically acceptable salt thereof, wherein: G is CR J is CR H is CR M is C—Y or CH—Y; Q is NR X is C Y is P is —A—L-nitrogen-containing heteroaryl, —A—L-substituted nitrogen-containing heteroaryl, wherein a, b and c are each, independently, an integer from 0 to 4, with the proviso that when a is 0, c is not 1 and when b is 0, c is not 1; A is O, N(—R L is C wherein * is the point of attachment to A; and  ** is the point of attachment to N; R Z is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R R R R R Z′ is aryl, substituted aryl, heteroaryl or substituted heteroaryl; or R R P taken together with either R any two of R said substituted alkyl, substituted alkenyl and substituted alkynyl comprise one to three substituents, and said substituted aryl and substituted heteroaryl comprises one to five substituents, and said substituents are independently selected from the group consisting of C said heteroaryl is an aromatic ring having from five to fifteen atoms in the ring, wherein one or more of the atoms in the ring is a heteroatom selected from the group consisting of oxygen, nitrogen and sulfur; said aryl is an aromatic carbocyclic ring having from five to fifteen carbon atoms; said arylalkyl is —C said heteroarylalkyl is —C said alkylaryl is -aryl-C said alkylheteroaryl is -heteroaryl-C with the proviso that the compound does not have the formula: wherein R 7 and R 8 are independently hydrogen, methyl, ethyl or isopropyl; k is zero or one; and R 4 is hydrogen, methyl, ethyl, n-propyl, n-butyl, pentyl, phenyl or substituted phenyl.