Patent ID: 6011030
Filing Date: 2000-01-04
Classification: A61K

Abstract:
A method of treating a patient with bacterial infection, so as to prevent release of bacterial endo-toxins, comprising:a) identifying a patient exhibiting symptoms of infection by bacteria, said bacteria having bacterial endotoxins;b) administering to said patient an antimicrobial amount of an antimicrobial compound which is selected from the group consisting of non-antibiotic antimicrobial compounds which are cell wall constituent-inactivating by cell wall crosslinking, non-antibiotic antimicrobial compounds which are endotoxin non-releasing, non-antibiotic antimicrobial compounds which are exotoxin-inactivating, and combinations thereof, without administration of an antibiotic to said patient and prior to substantial administration of any antibiotic to said patient subsequent to step a) above, so as to substantially inactivate said bacteria without releasing said endo-toxins and substantially reduce said symptoms; andc) then, after substantially inactivating in step b) said bacteria without releasing said endo-toxins and substantially reducing said symptoms with said antimicrobial compound, administering an antibiotic to said patient.