Patent ID: 6288096
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR19##or a stereo- or optical isomer or racemate thereof, in which formula {character pullout} is a single or double bond,R is H or alkyl,A is S, O or NH,B is C, CH or N,D is CN or --X--Y--Z and is situated in the ortho, meta or para position,D' is H, --O-alkyl, alkyl, halogen or --X--Y--Z and is situated in the ortho, meta or para position, whereinX is O, NR.sup.1, SO.sub.2 or S and R.sup.1 is H or alkyl,Y is SO.sub.2, CO or a chemical bond,Z is alkyl, alkyl substituted by one or more fluoro or chloro atoms, aryl, substituted aryl, alkylaryl, OR.sup.2 or NHR.sup.3, whereinR.sup.2 is alkyl, aryl, alkylaryl, substituted aryl or substituted alkyl, andR.sup.3 is H, alkyl, aryl, alkylaryl, substituted aryl or substituted alkyl,provided thatwhen X is O or NR.sup.1, then Y is either SO.sub.2 or CO, anda) when X is O or NR.sup.1, and Y is SO.sub.2, Z is selected from the group consisting of alkyl, alkyl substituted by one or more fluoro or chloro atoms, aryl, substituted aryl and alkylaryl,b) when X is O or NR.sup.1, and Y is CO, Z is selected from the group consisting of OR.sup.2 and NHR.sup.3 ;when X is SO.sub.2, then Y is a chemical bond and Z is selected from the group consisting of alkyl, alkyl substituted by one or more fluoro or chloro atoms, aryl, substituted aryl, alkylaryl and OR.sup.2 ;when X is S, then Y is a chemical bond and Z is selected from the group consisting of alkyl, alkyl substituted by one or more fluoro or chloro atoms, aryl, substituted aryl and alkylaryl;and further provided that when B is N, A is O,and wherein the compound, isomer, or racemate thereof may exist in the form of a pharmaceutically acceptable salt, solvate, and/or hydrate thereof.