Patent ID: 7238687
Filing Date: 2007-07-03
Classification: A61P,C07D

Abstract:
1. A method of treating a subject suffering from a condition associated with vasopressin receptor activity, which comprises administering to the subject a therapeutically effective amount of the compound of formula (I) wherein, R 1 is one to three substituents independently selected from hydrogen, halogen, amino, substituted amino, hydroxy, alkyloxy, phenyl, substituted phenyl, alkylthio, arylthio, alkyl-sulfoxide, aryl-sulfoxide, alkyl-sulfone, and aryl-sulfone; —R  wherein R′ is phenyl substituted independently with one or more groups selected from alkyl, substituted alkyl, alkoxy, nitro, amino,  optionally substituted with a group selected from alkyl, substituted alkyl, aldehyde, alkylcarbonyl, carboxyl, alkylcarboxyl, and —NZ  optionally substituted with alkyl or substituted alkyl,  optionally substituted with alkyl or substituted alkyl, —O(CO)O-alkyl, hydroxy, halo, alkyloxycarbonyl, —O— heterocyclyl optionally substituted with optionally substituted alkyl or alkylcarbonyl, and —NZ R R a represents a double bond; A is phenyl; X is CH; and n is 1, 2, or 3; or an optical isomer, enantionier, diastereomer, racemate thereof, or a pharmaceutically acceptable salt thereof wherein said condition is selected from hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, rental vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, rental water retention, dysmenorrheal, and nephritic syndrome.