Patent ID: 6531612
Filing Date: 2003-03-11
Classification: A61P,C07D,Y02A

Abstract:
A compound of the formula: whereinY is CHâ€”R2; R1 and R3 are each independently hydrogen or methyl and R2 is hydrogen, or R1 is hydrogen and R2 and R3 together are â€”CH2â€” thus forming a cyclopropyl ring; R4, R5 are each independently hydrogen or lower-alkyl; R6 is cycloalkyl, aryl, aryl-lower-alkyl, heteroaryl, or heteroaryl-lower-alkyl; R7 is â€”COâ€”Ra, â€”SO2â€”Rb or â€”CSâ€”NHâ€”Rc, wherein Ra is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, cycloalkyl-lower-alkoxy, aryl, heteroaryl, aryl-lower-alkyl, aryl-lower-alkoxy, heteroaryl-lower-alkoxy, aryl-lower-alkoxy-lower-alkyl, aryloxy-lower-alkyl, arylthio-lower-alkyl, aryl-lower-alkenyl, aryl-cycloalkyl, or Rd â€”NH, Rb is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl, heteroaryl, aryl-lower-alkyl, or aryl-lower-alkenyl, Rc is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl, heteroaryl, aryl-lower-alkyl, or heteroaryl-lower-alkyl, Rd is aryl-lower-alkyl; or a pharmaceutically acceptable salt or ester thereof.