Patent ID: 7108988
Filing Date: 2006-09-19
Classification: C12Q,G01N

Abstract:
1. A method of identifying a candidate agent for treating a lentivirus infection in a cell the method comprising: a) contacting a cell that produces a Vpr protein with a test agent; and b) determining the effect, if any, of the test agent on a peptidyl-prolyl cis/trans isomerase (PPIase) activity of a PPIase protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr, wherein an agent that inhibits PPIase activity of the PPIase protein reduces the level of Vpr in the cell, and wherein a test agent that reduces the level of Vpr in the cell is a candidate agent for treating a lentivirus infection in the cell.