Patent ID: 6784170
Filing Date: 2004-08-31
Classification: A61P,C07J

Abstract:
A compound having the structural formula (V) wherein:R1 is hydrogen or CR11R12, wherein R11 and R12 are hydrogen or lower alkyl; R2 is selected from the group consisting of hydrogen, hydroxyl, alkyl, â€”OR13, and â€”SR13 wherein R13 is alkyl; R3 is hydrocarbyl; R4, R5, and R7 are independently selected from the group consisting of hydrogen and lower alkyl; R6Mod is selected from the group consisting of hydrogen, alkyl, acyl, â€”C(O)-aryl, â€”C(O)-alkyl, hydroxyl-protecting groups, and hydroxyl-activating groups; R8a is oxo; R9 is hydrogen or alkyl; R10 is methyl or ethyl; and R20 is hydroxyl, hydroxymethyl, protected hydroxyl, protected hydroxymethyl, activated hydroxyl, activated hydroxymethyl, or in which m is zero or 1, p is an integer in the range of 1 to 7, R21 and R22 are lower alkyl or are linked together to form a five- or six-membered heterocycloalkyl ring; andQ1, Q2, Q3, and Q4 are independently selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkoxy, alkyl, halogen, amino, and alkyl-substituted amino.