Patent ID: 8362001
Filing Date: 2013-01-29
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) wherein Y and Z are independently selected from a) or b) such that one of Y and Z is selected from group a) and the other is selected from group b); Group a) is unsubstituted C i) C 6-10 aryl; or ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, indazolyl, benzoxazolyl, benzothiazolyl, benzofuranyl, benzothienyl, imidazo[1,2-a]pyridin-2-yl, quinolinyl, quinazolinyl, furanyl, thienyl, oxazolyl, pyrazolyl, and benzimidazolyl; wherein C independently substituted with one to two substitutents selected from the group consisting of bromo, chloro, fluoro, iodo, C 1-4 alkyl, C 1-4 alkoxy, and trifluoromethyl; and are substituted with one additional substituent selected from the group consisting of i) C 6-10 aryl; and ii) heteroaryl selected from the group consisting of pyrimidinyl, thienyl, quinolinyl, pyridinyl, thiazolyl, benzimidazolyl, pyrrolyl, and pyrazolyl; wherein phenyl of the C s is 0, 1 or 2; provided that when s is 2, R when s is 1, R with the proviso that when Y is phenyl, Z is other than 3-(pyrimidin-2-yl)phenyl, 4-(pyrimidin-2-yl)phenyl, 2-(2-fluorophenyl)phenyl, 2-(4-fluorophenyl)phenyl, 4-(3-cyanophenyl)phenyl 4-(pyrazol-1-yl)phenyl, 1-ethylcarbonyl-3,4-dihydro-1H-isoquinolin-2-yl, 2-phenylethynyl, 6-bromo-imidazo[1,2-α]pyridin-2-yl, and with the proviso that a compound of Formula (I) is other than a compound wherein Y is phenyl, Z is biphenyl-4-yl, s is 1, and R and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.