Patent ID: 8712749
Filing Date: 2014-04-29
Classification: C07K,C12N,C12Q,G01N

Abstract:
1. A method for identifying a candidate inhibitor using three-dimensional structure coordinates generated from a human Janus Kinase 3 crystal comprising a human Janus Kinase 3 protein, wherein said human Janus Kinase 3 protein consists of amino acid residues 810-1115 of SEQ ID NO: 1, wherein said human Janus Kinase 3 protein comprises a kinase domain, wherein said human Janus Kinase 3 kinase domain is in complex with a chemical entity selected from the group consisting of adenosine, ATP, an ATP analogue, AMP-PNP, a nucleotide triphosphate, a nucleotide diphosphate, and phosphate, and wherein said method comprises: