Patent ID: 8580936
Filing Date: 2013-11-12
Classification: A61K,A61P,C07K

Abstract:
1. A nucleic acid molecule comprising a polynucleotide sequence, the polynucleotide sequence encoding an FGFR1 fusion protein comprising a first polypeptide and a second polypeptide which is a fusion partner, wherein the first polypeptide consists of the extracellular domain of FGFR1-IIIc, which lacks, as compared to wild-type FGFR1-IIIc ECD of any of SEQ ID NOs: 92-94, a sequence consisting of VMTSPLYLE (SEQ ID NO: 247), AVMTSPLYLE (SEQ ID NO: 246), EERPAVMTSPLYLE (SEQ ID NO: 248), LEERPAVMTSPLYLE (SEQ ID NO: 249), or EALEERPAVMTSPLYLE (SEQ ID NO: 251), wherein the encoded extracellular domain of FGFR1-IIIc optionally lacks the native leader sequence, and wherein the fusion partner is chosen from an Fc polypeptide, albumin, a domain of a constant region of a heavy or light chain of a mammalian immunoglobulin, and a hinge and the CH2 and CH3 constant domains of a human IgG.