Patent ID: 7662629
Filing Date: 2010-02-16
Classification: A61K,C12N

Abstract:
1. A compound comprising: (a) a cationic peptide scaffold selected from the group of SEQ ID NO:2, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, and SEQ ID NO:18; and (b) a nuclear targeting peptide containing a nonclassical, nuclear localization sequence of SEQ ID NO:3 or SEQ ID NO:4, said cationic peptide scaffold being conjugated to said nuclear targeting peptide via a hydrolytic-resistant chemical linkage selected from the group of: succinimidyl 4-(N-maleimidomethyl)cyclohexane-I; bis-maleimidoethane; bis-maleimidohexane; 1,4-bis-maleimidyl-2,3-dihydroxybutane; 1,4-bis-maleimidobutane; N-succinimidyl[4-iodoacetyl]aminobenzoate; N-succinimidyl iodoacetate; succinimidyl 3-[bromoacetamido]propionate; succinimidyl 4-[p-maleimidophenyl]butyrate; succinimidyl-6-[(β-maleimidopropionamido)hexanoate]; N-succinimidyl 3-[2-pyridyldithio]propionate; N-[γ-maleimidobutyryloxy]sulfosuccinimide ester; N-[κ-maleimidoundecanoyloxy]-sulfosuccinimide ester; m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester; and N-succinimidyl-[4-vinylsulfonyl]benzoate.