Patent ID: 6627645
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein:Z1 is CR1, Z2 is CR2, Z3 is CR3, and Z4 is CR4; W1 is NR5, W2 is N, and W3 is CR6 or CG; or W1 is NG, W2 is N and W3 is CR6; G is of formula (II): Y is O, S, CHOH, â€”NHC(O)â€”, â€”C(O)â€”, â€”NR7â€”, â€”CH&boxH;Nâ€”, or absent; p is 1, 2, 3, 4 or 5; Z is CR8R9 or absent; both t's are the same and are selected from 1 or 2; each R1, R2, R3, and R4, independently, is H, amino, hydroxyl, halo, or straight- or branched-chain C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, C1-6 haloalkyl, â€”CN, â€”CF3, â€”OR11, â€”COR11, â€”NO2, â€”SR11, â€”NHC(O)R11, â€”C(O)NR12R13, â€”NR12R13, â€”NR11C(O)NR12R13, â€”SO2NR12R13, â€”OC(O)R11, â€”O(CH2)qNR12R13, or â€”(CH2)qNR12R13, where q is an integer from 2 to 6; each R5, R6, and R7, independently, is H, C1-6 alkyl; formyl; C3-6 cycloalkyl; each R8 and R9, independently, is H or straight- or branched-chain C1-8 alkyl; R10 is H, straight- or branched-chain C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkylidene, C1-8 alkoxy, C1-8 heteroalkyl, C1-8 aminoalkyl, C1-8 haloalkyl, C1-8 alkoxycarbonyl, C1-8 hydroxyalkoxy, C1-8 hydroxyalkyl, â€”SH, C1-8 alkylthio, â€”Oâ€”CH2â€”C5-6 aryl, C5-6 cycloalkyl, â€”C(O)NR12R13, â€”CR11R12R13, â€”OC(O)R11, â€”(O)(CH2)SNR12R13 or â€”(CH2)SNR12R13, s being an integer from 2 to 8; R10â€² is H, straight- or branched-chain C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkylidene, C1-8 alkoxy, C1-8 heteroalkyl, C1-8 aminoalkyl, C1-8 haloalkyl, C1-8 alkoxycarbonyl, C1-8 hydroxyalkoxy, C1-8 hydroxyalkyl, or C1-8 alkylthio, wherein at least one of R10 and R10â€² is not H; each R11, independently, is H, straight- or branched-chain C1-8 alkyl, C2-8 alkenyl, C2-8, alkynyl, C2-8 heteroalkyl, C2-8 aminoalkyl, C2-8 haloalkyl, C1-8 alkoxycarbonyl, C2-8 hydroxyalkyl, â€”C(O)â€”C5-6 aryl substituted with C1-3 alkyl or halo, C5-6 aryl, C5-6 heteroaryl, C5-6 cycloalkyl, C5-6 heterocycloalkyl, â€”C(O)NR12R13, â€”CR5R12R13, â€”(CH2)tNR12R13, t is an integer from 2 to 8; and each R12 and R13, independently, is H, C1-6 alkyl; C3-6 cycloalkyl; or C5-6 heteroaryl, optionally substituted with halo or C1-6 alkyl; or R12 and R13 together form a cyclic structure; or a pharmaceutically acceptable salt, ester or prodrug thereof.