Patent ID: 6190667
Filing Date: 2001-02-20
Classification: A61P,C07K,C12Q,G01N

Abstract:
A method for screening a molecule capable of inhibiting the growth or survival of Helicobacter, comprising:(a) contacting a parental Helicobacter strain with said molecule in a biological sample and contacting a Helicobacter strain deficient in UreI with said molecule;(b) comparing the acidity sensitivity of the parental strain to the acidity sensitivity of the UreI deficient strain, both of which have been contacted with the molecule of step (a); and(c) selecting said molecule that increases the acidity sensitivity of the parental strain as compared to the effect of said molecule on the acidity sensitivity of the UreI deficient strain, wherein acidity sensitivity is correlated with inhibiting Helicobacter growth or survival.