Patent ID: 6162904
Filing Date: 2000-12-19
Classification: A61K,C07K

Abstract:
A process for preparing an intravenously administrable gamma globulin solution which comprises:(a) heat treating an impure gamma globulin solution under time and temperature conditions sufficient for inactivating heat sensitive viruses;(b) subjecting the heat treated gamma globulin solution only once to polyethylene glycol fractionation for obtaining a purified gamma globulin solution wherein the polyethylene glycol fractionation is carried out in at least two stages in which impurities are removed as a precipitant in a first stage of polyethylene glycol fractionation and the gamma globulin is removed as a precipitant in a second stage of polyethylene glycol fractionation; and(c) treating the purified gamma globulin solution with an organic solvent for inactivating envelope viruses without a further polyethylene glycol fractionation.