Patent ID: 6159985
Filing Date: 2000-12-12
Classification: C07D,Y10S

Abstract:
A compound having the structure: ##STR20## wherein: (a) The bond between C.sub..alpha. and N.sub..beta. is a single bond, or a double bond whereby R2 (and H on C.sub..alpha.) are nil;(b) the bond between C.sub.5 and C.sub.6 is a single bond, or a double bond whereby R11 and R13 are nil;(c) R1 is selected from the group consisting of alkyl, aryl, and heterocycle;(d) R2, if not nil, is selected from the group consisting of hydrogen, alkyl, alkylacyl, arylacyl, alkylsulfonyl, and arylsulfonyl;(e) R3, R4 and R5 are each independently selected from the group consisting of hydrogen, halo, alkyl, aryl, heterocycle, nitro, cyano, and unsubstituted or alkyl- or aryl- or heterocycle-substituted hydroxy, thio, amino, amide, formyl (acyl), carboxy, and carboxamide; or R3 and R4 together are alkylene or heteroalkylene attached to adjacent carbons of the phenyl to which R3 and R4 are attached, and R5 is as specified in (e) above;(f) R6, R7 and R8 are each independently selected from the group consisting of hydrogen, halo, alkyl, aryl, heterocycle, nitro, cyano, and unsubstituted or alkyl- or aryl- or heterocycle-substituted hydroxy, thio, amino, amide, sulfonamide, formyl (acyl), carboxy, and carboxamide; or R6 and R7 together are alkylene or heteroalkylene attached to adjacent carbons of the phenyl to which R6 and R7 are attached, and R8 is as specified in (f) above;(g) R9 is selected from the group consisting of hydrogen, halo, alkyl, aryl, heterocycle, and carboxy and its alkyl and aryl esters and amides;(h) R10 and R12, and R11 and R13 if not nil, are each independently selected from the group consisting of hydrogen, alkyl, and aryl;and an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.