Patent ID: 6194543
Filing Date: 2001-02-27
Classification: A61K,C07K

Abstract:
A dendritic compound consisting of a focal group from which a first dendron and a second dendron extend, the first dendron comprising dendritically linked amino acid units I ##STR16##in which R.sup.1 is C.sub.1-6 -alkylene and X is selected from the group consisting of --O--, --S--, --NH-- and --CO--, and each unit of the first dendron has individually selected groups R.sup.1 and X, and wherein the first dendron has n levels (where n is at least 1) of said dendritically linked amino acid units and 2.sup.n terminal branches, and wherein at least 2 of which terminal branches are directly linked to anchor groups ##STR17##where Y is selected from --CO--, --NH--, --O-- and --S--, provided that at least one of X and Y is --CO--,R.sup.2 is a C.sub.6-24 -alkyl, -alkenyl, or -alkynyl group,R.sup.3 is selected from the group consisting of hydrogen, amine, blocked amine, hydroxyl, C.sub.1-24 alkoxy, thio, COOH, and organic groups containing at least one C.sub.6-24 -alkyl, -alkenyl or -alkynyl group, C.sub.1-6 -alkanoyloxy, or C.sub.1-6 -alkanoylamino groups, any of which may be substituted by a sugar moiety,and in which the second dendron has m levels (where m is 2 or more) of dendritically linked amino acid units of the formula I above in which the groups R.sup.1 and X may be the same as or different from one another and the same as or different from those of the amino acid units in the first dendron and wherein the second dendron has 2.sup.m terminal branches, each of which is selected from the group consisting of NH.sub.2, N.sup.+ H.sub.2 R.sup.11, in which R.sup.11 is hydrogen or C.sub.1-4 -alkyl, COOH, COO.sup.--, OH, SH, --XR.sup.12, --NHR.sup.12 or --COR.sup.12 where R.sup.12 is a hydroxymethyl group.