Patent ID: 9051551
Filing Date: 2015-06-09
Classification: A61K,A61P,C12N

Abstract:
1. A method of treating a disease cell with epidermal growth factor receptor (EGFR) inhibitor, comprising: a) selecting a disease cell expressing epidermal growth factor receptor (EGFR) as an untreated cell; b) selecting a dosage of EGFR inhibitor selective or specific for EGFR and/or its signaling pathway that is not cytostatic or cytotoxic to said untreated cell; c) contacting said untreated cell with a miR-7 miRNA, a precursor thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA, to produce a treated cell; and d) contacting said treated cell with said dosage of EGFR inhibitor that is not cytostatic or cytotoxic to said untreated cell, wherein said dosage of EGFR inhibitor that is not cytotoxic to said untreated cell is cytotoxic or cytostatic to said treated cell.