Patent ID: 6432982
Filing Date: 2002-08-13
Classification: A61P,C07D

Abstract:
A compound of the formula (I): whereinR1 is â€”H, â€”OH, â€”O(C1-C4 alkyl), â€”Oâ€”CO(C1-C6 alkyl), â€”OSO2(C4-C6 alkyl, or â€”OCOAr where Ar is optionally substituted phenyl; R2 is â€”H, â€”OH, â€”Cl, â€”Br, â€”(C1-C4 alkyl), â€”OCO(C1-C6 alkyl), â€”OSO2(C4-C6 alkyl, or â€”OCOAr where Ar is optionally substituted phenyl,; R3 is â€”H, â€”F, â€”Cl, â€”(C1-C4 alkyl), â€”CN, or â€”O(C1-C3 alkyl); R4 â€”H, â€”F, â€”Cl, â€”(C1-C4 alkyl), â€”CN, or â€”O(C1-C3 alkyl); R5 is â€”H, â€”F, â€”Cl, â€”(C1-C4 alkyl), or â€”O(C1-C3 alkyl); and R6 is â€”H, â€”F, â€”Cl, â€”(C1-C4 alkyl), or â€”O(C1-C3 alkyl); with the provisos that R3, R4, R5 and R6 an not all be hydrogen, and that when one of R3, R4, R5 or R6 is C1-C4 alkyl, no more than two of R3, R4, R5 and R6 can be hydrogen: Y is â€”COâ€”, â€”CHOHâ€”, or â€”CH2â€”; R7 and R8 are independently C1-C4 alkyl or combine to form, with the nitrogen to which they are attached, 1-piperidinyl, 1-pyrrolidinyl, 1-hexamethyleneimino, or morpholino; or a pharmaceutically acceptable salt thereof.