Patent ID: 8399424
Filing Date: 2013-03-19
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method for increasing the amount of an intracellular early-response protein selected from the group consisting of inducible Nitric Oxide Synthase (iNOS), Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) and IκB, comprising introducing into a cell an antisense RNA comprising a nucleotide sequence complementary to the 3′-untranslated region (UTR) of an mRNA encoding iNOS, CINC-1 or IκB; whereby the introduction of said antisense RNA comprising a nucleotide sequence complementary to the 3′-untranslated region (UTR) of an mRNA encoding iNOS, CINC-1 or IκB into said cell increases the amount of intracellular iNOS, CINC-1 or IκB, respectively.