Patent ID: 7678916
Filing Date: 2010-03-16
Classification: A61K,A61P,C07D

Abstract:
1. A process of preparing crystalline rosiglitazone maleate Form A, having an X-ray diffraction pattern with characteristic peaks (2θ): 9.5, 15.86, 15.02, 17.00, 18.52, 21.99, 23.58, 25.06 and 26.55, which process comprises preparing a mixture which comprises rosiglitazone free base, and maleic acid, present in a water miscible solvent, stirring said mixture and heating to obtain a solution, filtering the solution to obtain a clear filtrate and adding a water immiscible solvent thereto, followed by stirring and cooling so as to isolate crystalline rosiglitazone maleate Form A.