Patent ID: 6452056
Filing Date: 2002-09-17
Classification: C07C

Abstract:
A process for producing a fluorine-containing benzyl alcohol derivative represented by the following general formula (3), which comprises subjecting a fluorine-containing benzonitrile derivative represented by the following general formula (1) to a reduction reaction with a reducing agent consisting essentially of hydrogen in the presence of a Raney nickel catalyst or a Raney cobalt catalyst in a non-polar solvent to obtain a fluorine-containing benzylamine derivative represented by the following general formula (2), and replacing the amino group in said fluorine-containing benzylamine derivative with a hydroxyl group by one of the following processes:Process 1: a process wherein the compound (2) is converted to a tertiary amine compound, ethyl bromide is reacted therewith, and sodium acetate is reacted therewith under an alkali condition in a methanol solvent, Process 2: a process wherein the compound (2) is reacted with 2,4,5-triphenylpyrylium tetrafluoroborate salt and sodium (2-hydroxymethyl)benzoate in the presence of a phase transfer catalyst, Process 3: a process wherein the compound (2) is reacted with an acid and an alkali nitrite, Process 4: a process wherein a reaction is carried out in the same manner as in Process 3, employing a carboxylic acid compound as the acid, and the obtained reaction product is hydrolyzed, wherein X is a halogen atom, when m is an integer of 2 or more, each X may be the same or different, and m is an integer of from 0 to 4.