Patent ID: 6217845
Filing Date: 2001-04-17
Classification: A61K,C07D,G01N,Y10S

Abstract:
A metal-labeled macromolecule suitable for use as an imaging agent or as a radiochemical formed by contacting a reduced metal species selected from the group consisting of Te, Re and Mo with a protein, glycoprotein or peptide conjugate having free hydrazine/hydrazide groups capable of binding with said metal species wherein said conjugate is formed by reaction of a a protein, glycoprotein or peptide having a reactive free primary amino group with a compound of the formula (I) or (II): ##STR5##wherein:A is a carbon or nitrogen atom;B is a carbon or nitrogen atom;D is a direct bond, CH.sub.2, C.dbd.O or ##STR6##E is C.dbd.O or, together with F, forms a maleimidyl group;F is a group readily replaced by a primary amine in neutral or basic aqueous media when E is C.dbd.O or together with E forms a maleimidyl group;R is hydrogen or a lower alkyl group;R' and R"" may be the same or different and are selected from hydrogen and lower alkyl;X is a negative counterion.