Patent ID: 6521757
Filing Date: 2003-02-18
Classification: A61P,C07D

Abstract:
A method for the preparation of a compound of general Formula (I): or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising the step of cyclizing an azomethine ylide of general Formula (II): â€ƒwherein, A is a cyclic group being an optionally substituted aryl group; Z is oxygen; n is 1; and Y is selected from the group consisting of: hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted aryl, optionally substituted heterocyclyl, carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate and cyano, and W and X, together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group.