Patent ID: 8927011
Filing Date: 2015-01-06
Classification: A61K,A61P

Abstract:
1. A process for producing tablets containing fumaric acid and a morphinan compound, which is N-[(5R,6R,14S)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihyroxymorphinan-6-yl]phthalimide or a pharmaceutically acceptable acid addition salt thereof, which process comprises granulating by wet granulation the morphinan compound or a pharmaceutically acceptable acid addition salt thereof together with (an) excipient(s) and separately granulating fumaric acid by wet granulation together with (an) excipient(s) prior to adding fumaric acid, in an amount of 0.01 to 500 parts by weight per 1 part by weight of the morphinan compound or a pharmaceutically acceptable acid addition salt thereof, thereto in the form of a fine powder, not less than 90% by weight of which has a particle size of not more than 355 μm.