Patent ID: 6440964
Filing Date: 2002-08-27
Classification: A61K,Y10S

Abstract:
A topical pharmaceutical composition for treating acute otitis externa infections or ophthalmic infections attributable to a Microbacterium species selected from the group consisting of Microbacterium otitidis and Microbacterium alconae, comprising of one or more compounds of the following formula in an amount effective to eradicate said Microbacterium species: wherein: A is CH, CF, CCl, Câ€”OCH3, or N; X1 is H, halogen, NH2, or CH3; R1 is C1 to C3 alkyl, FCH2CH2, cyclopropyl or phenyl, optionally mono-, di- or tri-substituted by halogen, or A and R1 together can form a bridge of formula Câ€”Oâ€”CH2â€”CH(CH3); R2 is H, C1 to C3 alkyl (optionally substituted by OH, halogen or NH2), or 5-methyl-2-oxo-1,3-dioxol-4-yl-methyl; and B is a selected from the group consisting of: â€ƒwherein: Y is O or CH2; R3 is C2â€”C5 alkoxyl, CH2â€”COâ€”C6H5, CH2CH2CO2Râ€², Râ€²O2Câ€”CH&boxH;Câ€”CO2Râ€², CH&boxH;CHâ€”CO2Râ€² or CH2CH2â€”CN, wherein: Râ€² is H or C1 to C3 alkyl; R4 is H, C2 to C3 alkyl, C2â€”C5 alkoxyl, CH2â€”COâ€”C6H5, CH2CH2CO2Râ€², Râ€²O2Câ€”CH&boxH;Câ€”CO2Râ€², CH&boxH;CHâ€”CO2Râ€², CH2CH2â€”CN or 5-methyl-2-oxo-1,3-dioxol-4-yl-methyl, wherein: Râ€² is H or C1 to C3 alkyl; and their pharmaceutically useful hydrates and salts; and a pharmaceutically acceptable vehicle therefor.