Patent ID: 6387893
Filing Date: 2002-05-14
Classification: A61K,A61P,C07D

Abstract:
A compound of formula: wherein Q is A1 is a benzene ring, substituted benzene, heterocyclic or substituted heterocyclic, wherein each of the substituents on substituted benzene or substituted heterocyclic is independently halogen, cyano, nitro, C1-C8 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, fluorinated C1-C8 alkyl, fluorinated C1-C6 alkoxy, fluorinated C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalky; A2 independently has the same definition as set forth for A1; Z is C(RbRc)C(RbRc), C(Rb)&boxH;C(Rc), C(RbRc)C(&boxH;O), or C(&boxH;O)C(RbRc); each Y is independently hydrogen, halogen, cyano, nitro, C1-C8 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, fluorinated C1-C8 alkyl, fluorinated C1-C6 alkoxy, fluorinated C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; each X1 is independently hydrogen, halogen, cyano, nitro, C1-C8 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, fluorinated C1-C8 alkyl, fluorinated C1-C6 alkoxy, fluorinated C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; each R1 is a substituent connected to a ring atom other than N or spiro subsituted carbon and is independently hydrogen or C1-C4 alkyl; R2, R3, R4 and R5 are each independently selected from hydrogen, C1-C6 alkyl, and C3-C8 cycloalkyl; R6 is hydrogen, C1-C8 alkyl, or fluorinated C1-C8 alkyl; R7 and R8 are each independently selected from hydrogen, halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, fluorinated C1-C6 alkoxy, CO2Rd, C2-C8 alkoxyalkyl, and fluorinated C2-C8 alkoxyalkyl; R9 and R10 are each independently selected from hydrogen, C1-C6 alkyl, fluorinated C1-C6 alkyl, C3-C8 cycloalkyl, fluorinated C3-C8 cycloalkyl, C4-C20 alkylcycloalkyl, C4-C20 cycloalkylalkyl, or CHReRf; R12 and R14 are each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, fluorinated C1-C6 alkoxy, fluorinated C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, and fluorinated C2-C8 alkoxyalkyl; or one of R12 and R14 is CO2Rd or CON(Re)2 and the other of R12 and R14 is as earlier defined; or R12 and R14 together with the carbon atom to which they are attached form C3-C7 cycloalkyl or substituted C3-C7 cycloalkyl, wherein the each of the substituents on substituted cycloalkyl is independently halogen, cyano, C1-C6 alkyl, fluorinated C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkoxy, CO2Rd, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; R16 and R18 are each independently selected from hydrogen, C1-C6 alkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, heterocyclic, and substituted heterocyclic, provided that R16 and R18 are not both hydrogen; wherein each of the substituents on substituted phenyl or substituted naphthyl is independently halogen, C1-C6 alkyl, fluorinated C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkoxy, CO2Rd, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; and wherein each of the substituents on substituted heterocyclic is independently halogen, C1-C6 alkyl, fluorinated C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkoxy, C2-C8 alkoxyalkyl, fluorinated C2-C8 alkoxyalkyl, or phenyl; Ra is hydrogen, C1-C6 alkyl, fluorinated C1-C6 alkyl, C3-C8 cycloalkyl, fluorinated C3-C8 cycloalkyl, C4-C20 alkylcycloalkyl, or C4-C20 cycloalkylalkyl; Rb and Rc are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, fluorinated C1-C6 alkyl, phenyl, and substituted phenyl, wherein each of the substituents on the substituted phenyl is independently halo, C1-C6 alkyl, fluorinated C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkoxy, CO2Rd, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; Rd is hydrogen, C1-C6 alkyl, fluorinated C1-C6 alkyl, C3-C8 cycloalkyl, fluorinated C3-C8 cycloalkyl, C4-C20 alkylcycloalkyl, or C4-C20 cycloalkylalkyl; Re is hydrogen or C1-C6 alkyl; Rf is phenyl or substituted phenyl, wherein each of the substituents on substituted phenyl is halogen, cyano, C1-C6 alkyl, fluorinated C1-C6 alkyl, C1-C6 alkoxy, fluorinated C1-C6 alkoxy, or CO2Rd, C2-C8 alkoxyalkyl, or fluorinated C2-C8 alkoxyalkyl; m and n are each independently integers from 0 to 3; p is an integer from 1 to 5; q is 0 or 1, provided that when Q is then q is 0; s is an integer from 0 to 4; t1 is an integer from 0 to 4; and t2 is an integer from 0 to 5; or a pharmaceutically acceptable salt thereof.