Patent ID: 6541495
Filing Date: 2003-04-01
Classification: A61K

Abstract:
A method of treating cancer susceptible to compounds of the following formula, in mammals in need of such treatment, comprising administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, or hydrate, wherein:R1 is â€”COY1 wherein Y1 is hydroxy, (C1-C3)alkoxy, phenoxy, benzyloxy, amino, (C1-C4)alkanoylamino, (C1-C4)alkanesulfonylamino, benzenesulfonylamino, naphthalenesulfonylamino, di[(C1-C4)]aminosulfonylamino or one of the foregoing groups mono- or disubstituted with (C1-C3)alkyl, trifluoromethyl, hydroxy, (C1-C3)alkoxy, fluoro or chloro; R2 and R3 are independently selected from hydrogen, (C1-C10)alkyl, and phenyl; X is O; Y is N; Z is S-methyl, S-propyl or S-octyl; n is one; r is an integer ranging from one to five, the moiety (CH2)r optionally including one or more carbon-carbon double or triple bond when r is an integer of from two to five; and s is an integer of from one to five, the moiety (CH2)s optionally including one or more carbon-carbon double or triple bond when s is an integer of from 2 to 5.