Patent ID: 8604014
Filing Date: 2013-12-10
Classification: A61K,A61P,Y10T

Abstract:
1. A method for determining compounds to be used in combination for the treatment of cancer comprising: a) administering a therapeutic combination of a compound having Formula I or II, and a chemotherapeutic agent to HER2-amplified breast cancer cells in laminin-rich, reconstituted basement membrane media, wherein the chemotherapeutic agent targets, binds to, or modulates a HER2 receptor, and b) measuring inhibition of cellular proliferation wherein nonmalignant and malignant mammary cells are discriminated by one or more phenotypic difference selected from cell viability and acinar morphogenesis; wherein the Formula I or II compound is selected from a compound of Formula Ia, Formula Ib and Formula IIa: or stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof.