Patent ID: 6203729
Filing Date: 2001-03-20
Classification: A61P,C07D,C08K,G02B

Abstract:
A compound having the following formula (I): ##STR17##in which:R.sub.1 and R.sub.2, which are identical or different, independently represent:a hydrogen,a linear or branched alkyl group which comprises 1 to 12 carbon atoms,a cycloalkyl group which comprises 3 to 12 carbon atoms,an aryl or heteroaryl group which comprises in its basic structure 6 to 24 carbon atoms or 4 to 24 carbon atoms respectively and at least one heteroatom selected from sulphur, oxygen, and nitrogen; said basic structure being optionally substituted with at least one substituent selected from:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an -NH.sub.2 group,an -NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR18##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group, oran aralkyl or heteroaralkyl group, the alkyl part of which is linear or branched and comprises 1 to 4 carbon atoms, and the aryl part of which has the same definition as that given above for the aryl and heteroaryl group, orsaid two substituents, R.sub.1 and R.sub.2, together form an adamantyl, norbornyl, fluorenylidene, di(C.sub.1 -C.sub.6)alkylanthracenylidene, or spiro(C.sub.5 -C.sub.6)cyclo-alkylanthracenylidene group; said group being optionally substituted with at least one [of the substituents listed above for R.sub.1, R.sub.2 : an aryl or heteroaryl group] substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -Cl.sub.2) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR19##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group;R.sub.3 represents:a methyl group,a CR.sub.5 R.sub.6 OR.sub.7 group in which:R.sub.5 and R.sub.6 are identical or different and represent, independently, hydrogen or a linear or branched alkyl group which comprises 1 to 6 carbon atoms, andR.sub.7 represents:hydrogen,a linear or branched alkyl group which comprises 1 to 6 carbon atoms,an aralkyl group, wherein the alkyl group comprises 1 to 3 carbon atoms and the aryl group is selected from a phenyl or naphthyl group optionally substituted with at least one substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR20##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group,a CH.sub.2 CN group,a CH.sub.2 COOR.sub.8 group in which R.sub.8 represents a hydrogen or a linear or branched alkyl group which comprises 1 to 6 carbon atoms, ora COR, group in which Rg represents a linear or branched alkyl group which comprises 1 to 6 carbon atoms, a cycloalkyl or bicycloalkyl group which comprises 3 to 12 carbon atoms, a phenyl or naphthyl group optionally substituted with at least one substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR21##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group, ora --COR.sub.10, --COOR.sub.10, or CONHR.sub.10 group, wherein R.sub.10 represents a linear or branched alkyl group comprising 1 to 6 carbon atoms, or a cycloalkyl group comprising 3 to 6 carbon atoms, or a linear or branched alkenyl group which comprises 2 to 12 carbon atoms, or a phenyl or benzyl group which is optionally substituted with at least one substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR22##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group; andR.sub.4 represents:hydrogen,a linear or branched alkyl group which comprises 1 to 12 carbon,a cycloalkyl group which comprises 3 to 12 carbon atoms,a linear or branched alkenyl group which comprises 2 to 12 carbon atoms,a phenyl or benzyl group which is optionally substituted with at least one substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR23##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group,a --COR.sub.10, --COOR.sub.10, or CONHR.sub.10 group, wherein R.sub.10 represents a linear or branched alkyl group comprising 1 to 6 carbon atoms, or a cycloalkyl group comprising 3 to 6 carbon atoms, or a linear or branched alkenyl group which comprises 2 to 12 carbon atoms, or a phenyl or benzyl group which is optionally substituted with at least one substituent selected from the group consisting of:a halogen,a hydroxy group,a linear or branched alkyl group comprising 1 to 12 carbon atoms,a linear or branched alkoxy group comprising 1 to 12 carbon atoms,a haloalkyl or haloalkoxy group corresponding to the (C.sub.1 -C.sub.12) alkyl or alkoxy groups above respectively which are substituted with at least one halogen atom,a linear or branched alkenyl group comprising 2 to 12 carbon atoms,an --NH.sub.2 group,an --NHR group, R representing a linear or branched alkyl group comprising 1 to 6 carbon atoms,a ##STR24##group in which R' and R"" are identical or different and independently represent a linear or branched alkyl group comprising 1 to 6 carbon atoms, or R' and R"", together with the nitrogen atom to which they are bound, represent a 5- or 7-membered ring which can comprise at least one other heteroatom selected from oxygen, sulphur, and nitrogen, said nitrogen being optionally substituted with an R'"" group which is a linear or branched alkyl group comprising 1 to 6 carbon atoms, anda methacryloyl group or an acryloyl group, ora methacryloyl group or an acryloyl group.