Patent ID: 7655628
Filing Date: 2010-02-02
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating liver cirrhosis or interstitial pulmonary fibrosis, comprising administering to a patient in need thereof a polypeptide that binds to Wnt protein to competitively inhibit the binding of Wnt protein to its receptor and to treat liver cirrhosis or interstitial pulmonary fibrosis, wherein said polypeptide is selected from the group consisting of: a) mature secreted apoptosis-related protein 1 (SARP-1) comprising at least 90% sequence identity to amino acids 21 to 295 of SEQ ID NO:2; b) a fragment of a) comprising at least the cysteine rich frizzled domain thereof; c) a polypeptide comprising SEQ ID NO:2; d) a polypeptide comprising amino acids 21 to 295 of SEQ ID NO:2; e) a polypeptide comprising amino acids 24 to 295 of SEQ ID NO:2; f) a polypeptide comprising amino acids 25 to 295 of SEQ ID NO:2; g) a polypeptide comprising amino acids 26 to 295 of SEQ ID NO:2; h) a polypeptide comprising amino acids 27 to 295 of SEQ ID NO:2; i) a polypeptide comprising amino acids 28 to 295 of SEQ ID NO:2; j) a polypeptide comprising amino acids 37 to 295 of SEQ ID NO:2; k) a mutein of any of (a) to (j), wherein the amino acid sequence of said mutein has at least 90% sequence identity to at least one of the sequences in (a) to (j); l) the mutein of (k), wherein any changes in the amino acid sequence are conservative amino acid substitutions to the amino acid sequences in (k); m) a salt, an isoform of (a)-(l), or a fusion protein of any of (a) to (l).