Patent ID: 7326700
Filing Date: 2008-02-05
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I): wherein: R R R wherein B is selected from the group of wherein: A is CH or N; R R R  azido, amino, —NH[lower alkyl], —N [lower alkyl] and R is selected from hydrogen, (C wherein: R cycloalkyl lower alkyl, halo lower alkyl, cyano lower alkyl, lower alkyl thiol, alkoxycarbonyl lower alkyl, alkylthio lower alkyl, indolyl lower alkyl; aryl, optionally substituted with 1 to three substituents selected from lower alkyl, hydroxy, lower alkoxy, aryl lower alkoxy, halogen, —CF 3 , —OCF 3 , —OCF 2 H, —OCH 2 F, -OCH 2 CF 3 , —OCF 2 CF 3 , —OCH 2 CHF 2 , alkylamido lower alkyl, dialkylamido lower alkyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, piperidinyl, —SCF 3 , —SO 2 [lower alkyl], sulfonyl cycloalkyl, (C 7 -C 12 ) aryl lower alkyl, wherein the aryl moiety is optionally substituted with halogen or alkoxy; R R R R R R benzodioxolyl, benzodioxolyl lower alkyl, benzodioxanyl, benzodioxanyl lower alkyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, furancarbonyl, —SO 2 [lower alkyl], aryl optionally substituted by one to three substituents selected independently, from the group of hydrogen, halogen, (C 1 -C 6 ) lower alkyl, (C 3 -C 6 ) lower alkenyl, (C 3 -C 6 ) lower alkynyl, lower alkoxy, —CF 3 , —OCF 3 , OCHF 2 , —OCH 2 F, —OCH 2 CF 3 , —OCF 2 CF 3 , —OCH 2 CHF 2 , —CO lower alkyl, —CN, nitro, —SCH 3 , aryl lower alkoxy, aryl lower alkoxy carbonyl, indolyl, morpholino or thiomorpholino; or (C 7 -C 12 ) lower aralkyl wherein the aryl moiety is optionally substituted with halogen, or lower alkoxy; R R R R R R R R R R R R X′ is O, S, SO, or SO Y′=CH K=Y′ or N[(C m is an integer from 1 to 4; n is an integer from 1 to 4; p isanintegerfrom 2 to 4; q is an integer from 1 to 5; r is an integer from 1 to 2; s is an integer from 0 to 1; or pharmaceutically acceptable salt form thereof.