Patent ID: 8636929
Filing Date: 2014-01-28
Classification: A61K,A61P,B82Y

Abstract:
1. A process for the production of nanoporous foamed active substance-containing preparations, wherein the active substance is present in a pharmaceutically acceptable polymer, wherein: in stage a), loading of a polymeric molding compound or a polymer melt with a propellant is effected at a pressure above 10 MPa and at a temperature at which the propellant is in the supercritical state, in stage b), heating or cooling of the laden polymeric molding compound or melt is carried out under a pressure above 10 MPa to a temperature which lies in the range from −40 to +50° C. around the glass transition temperature of the polymeric molding compound prior to loading and in stage c), depressurization of the polymeric molding compound or melt laden in stage a) and heated or cooled under pressure in stage b) is effected with a depressurization rate in the range from 15,000 to 2,000,000 MPa/sec, wherein the temperature at the instant depressurization begins lies in the range from −40 to +50° C. around the glass transition temperature of the polymeric molding compound prior to loading and adding the active substance to the pharmaceutically acceptable polymer before melting, during stage b), or between stage b) and stage c).