Patent ID: 9012242
Filing Date: 2015-04-21
Classification: A61K,G01N

Abstract:
1. A multivalent fluorescent probe having the structure: wherein X and Y are O, S, Se or CR wherein R represents a targeting moiety and the four targeting moieties are linked to X, Y, N and N+ via the L1, L2, L3 and L4, wherein L1, L2, L3 and L4 comprise 10 to 50 linear atoms selected from carbon, nitrogen, oxygen, phosphorus and sulfur that are further substituted by hydrogen, alkyl having from 1 to 20 carbons, alkoxy having from 1 to 20 carbons, trifluoromethyl, halogen, methylthio, sulfonyl, carbonyl, hydroxy, amino, thiol, amino acid residues RGD, zinc (Zn) or a ligand that binds to a cell surface receptor; wherein the probe emits light having a wavelength of 550 to 1200 nm and wherein the targeting moiety is a molecule that specifically targets the multivalent fluorescent probe to a specific cell.