Patent ID: 6815549
Filing Date: 2004-11-09
Classification: C07D

Abstract:
A process for the preparation of Fexofenadine, which comprises:a) reaction of a compound of formula (1): wherein R1 is a halogen or an alkyl or arylsulfonate group, with the compound of formula (2): b) condensation of the resulting compound of formula (3): with a compound of formula (4): wherein R2 is hydrogen or C1-C4 alkyl, and R3 is a halogen or an alkyl or arylsulfonate, in the presence of metal catalysts based on copper(I) or mixtures of palladium(0) and copper(I) in the presence of a base; c) transformation of the resulting compound of formula (5): into compound (6): by treatment with water in the presence of a catalyst based on palladium (II), platinum (II), or ruthenium (III), optionally in the presence of ligands.