Patent ID: 7247425
Filing Date: 2007-07-24
Classification: G01N

Abstract:
1. A method of determining whether a polynucleotide sequence of a non-human primate which has been or may be associated with a physiological trait in the non-human primate has undergone evolutionarily significant change relative to humans that exhibit the physiological trait to a lesser degree, comprising: (a) comparing the non-human polynucleotide sequence with the corresponding human primate polynucleotide sequence to identify any nucleotide changes, wherein the polynucleotide sequence is selected from the group consisting of ICAM-1 polynucleotide sequence, ICAM-2 polynucleotide sequence, ICAM-3 polynucleotide sequence, CD98 polynucleotide sequence, p44 polynucleotide sequence, IFN-p56k polynucleotide sequence, and Staf50 polynucleotide sequence; and (b) determining whether said non-human nucleotide changes are evolutionarily significant, whereby a polynucleotide sequence of a non-human primate which has been or may be associated with a physiological trait in the non-human primate has undergone evolutionarily significant change relative to humans that exhibits the physiological trait to a lesser degree is identified.