Patent ID: 6649658
Filing Date: 2003-11-18
Classification: A61P,C07C,C07D

Abstract:
A compound having the formula wherein, when X=OZ=H, &boxH;CHAr, &boxH;C(OH)COOEt, &boxH;NOR; Y=H, NH2, NH3+X1âˆ’, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X1âˆ’=pharmaceutically acceptable anion; Ar=aryl selected from among the group consisting of: phenyl, 4chlorophenyl, 2-furyl, 2-thienyl, 2 hydroxyphenyl and 2-acetophenyl; R=H, C1-C4 alkyl, C4-C6 cycloalkyl, CH2COOH, CH2COOEt, CH2COCH3, CH2CN, CH2COOCH2COOEt, CH2C6H5; with the proviso that when X=O ad Y=HZ is other than H; and when X=dimethylamino, diethylamino, pyrrolidino, piperidino, or morpholino; Y=H; Z=EL CONHAr, CONHR; Ar=aryl; R=H, C1-C4 alkyl, C4-C6 cycloalkyl; with the proviso that when Z=H, X is other than pyrrolidino.