Patent ID: 6054435
Filing Date: 2000-04-25
Classification: C07H

Abstract:
A compound selected from the group consisting of a compound of formula I ##STR17## a compound of formula II ##STR18## and a compound of formula III ##STR19## or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof, wherein either:(a) Y and Z taken together define a group X,and X is selected from the group consisting of(1) .dbd.O,(2) .dbd.N--OH,(3) .dbd.N--O--R.sup.1 where R.sup.1 is selected from the group consisting of(a) unsubstituted C.sub.1 -C.sub.12 alkyl,(b) C.sub.1 -C.sub.12 alkyl substituted with aryl,(c) C.sub.1 -C.sub.12 alkyl substituted with substituted aryl,(d) C.sub.1 -C.sub.12 alkyl substituted with heteroaryl,(e) C.sub.1 -C.sub.12 alkyl substituted with substituted heteroaryl,(f) C.sub.3 -C.sub.12 cycloalkyl, and(g) --Si--(R.sup.2)(R.sup.3)(R.sup.4) wherein R.sup.2, R.sup.3 and R.sup.4 are each independently selected from the group consisting of C.sub.1 -C.sub.12 alkyl and aryl; and(4) .dbd.N--O--C(R.sup.5)(R.sup.6)--O--R.sup.1 where R.sup.1 is as previously defined and R.sup.5 and R.sup.6 are each independently selected from the group consisting of(a) hydrogen,(b) unsubstituted C.sub.1 -C.sub.12 alkyl,(c) C.sub.1 -C.sub.12 alkyl substituted with aryl,(d) C.sub.1 -C.sub.12 alkyl substituted with substituted aryl,(e) C.sup.1 -C.sub.12 alkyl substituted with heteroaryl, and(f) C.sup.1 -C.sub.12 alkyl substituted with substituted heteroaryl,or R.sup.5 and R.sup.6 taken together with the atom to which they are attached form a C.sub.3 -C.sub.12 cycloalkyl ring;or(b) one of Y and Z is hydrogen and the other is selected from the group consisting of(1) hydrogen,(2) hydroxy,(3) protected hydroxy, and(4) NR.sup.7 R.sup.8 wherein R.sup.7 and R.sup.8 are independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl, or R.sup.7 and R.sup.8 are taken with the nitrogen atom to which they are connected to form a 3- to 7-membered ring which, when the ring is a 5- to 7-membered ring, may optionally contain a hetero function selected from the group consisting of --O--, --NH--, --N(C.sub.1 -C.sub.6 -alkyl-)--, --N(aryl)--, --N(aryl-C.sub.1 -C.sub.6 -alkyl-)--, --N(substituted-aryl-C.sub.1 -C.sub.6 -alkyl-)--, --N(heteroaryl)-, --N(heteroaryl-C.sub.1 -C.sub.6 -alkyl-)--, --N(substituted-heteroaryl-C.sub.1 -C.sub.6 -alkyl-)--, and --S-- or --S(O).sub.n --, wherein n is 1 or 2;R.sup.a is hydrogen or hydroxy;R.sup.b is hydrogen or a hydroxy protecting group;L is methylene or carbonyl, provided that when L is methylene, T is --O--;T is selected from the group consisting of --O--, --NH--, and --N(W-R.sup.d)--, wherein W is absent or is selected from the group consisting of --O--, --NH--CO--, --N.dbd.CH-- and --NH--, and R.sup.d is selected from the group consisting of(1) hydrogen,(2) C.sub.1 -C.sub.6 alkyl optionally substituted with one or more substituents selected from the group consisting of(a) aryl,(b) substituted aryl,(c) heteroaryl,(d) substituted heteroaryl,(e) hydroxy,(f) C.sub.1 -C.sup.6 alkoxy,(g) NR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8 are as defined previously, and(h) --CH.sub.2 --M--R.sup.9,wherein M is selected from the group consisting of(i) --C(O)--NH--,(ii) --NH--C(O)--,(iii) --NH--,(iv) --N.dbd.,(v) --N(CH.sub.3)--,(vi) --NH--C(O)--O--(vii) --NH--C(O)--NH--(viii) --O--C(O)--NH--(ix) --O--C(O)--O--(x) --O--,(xi) --S(O).sub.n --, wherein n is 0, 1 or 2,(xii) --C (O)--O--,(xiii) --O--C(O)--, and(xiv)--C(O)--; andwherein R.sup.9 is selected from the group consisting of:(i) C.sub.1 -C.sub.6 alkyl, optionally substituted with a substituent selected from the group consisting of(aa) aryl,(bb) substituted aryl,(cc) heteroaryl, and(dd) substituted heteroaryl;(ii) aryl,(iii) substituted aryl,(iv) heteroaryl,(v) substituted heteroaryl, and(vi) heterocycloalkyl;(3) C.sub.3 -C.sub.7 cycloalkyl,(4) aryl,(5) substituted aryl,(6) heteroaryl, and(7) substituted heteroaryl;X' is selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.10 alkenyl, and C.sub.3 -C.sub.10 alkynyl;Y' and Z' are independently selected from the group consisting of:(c) optionally substituted aryl, and(d) optionally substituted heteroaryl,with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl;and A, B, D and E are independently selected from the group consisting of:(a) hydrogen;(b) C.sub.1 -C.sub.6 alkyl, optionally substituted with one or more substituents selected from the group consisting of:(i) aryl;(ii) substituted aryl;(iii) heteroaryl;(iv) substituted heteroaryl;(v) heterocycloalkyl;(vi) hydroxy;(vii) C.sub.1 -C.sub.6 alkoxy;(viii) halogen consisting of Br, Cl, F or I; and(ix) NR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8 are as previously defined;(c) C.sub.3 -C.sub.7 cycloalkyl;(d) aryl;(e) substituted aryl;(f) heteroaryl;(g) substituted heteroaryl;(h) heterocycloalkyl; and(i) a group selected from option (b) as above defined A, B, D and E further substituted with --M--R.sup.9, wherein M and R.sup.9 are as previously defined, with the proviso that at least two of A, B, D and E are hydrogen;or any one pair of substituents, consisting of AB, AD, AE, BD, BE or DE, is taken together with the atom or atoms to which they are attached to form a 3- to 7-membered ring optionally containing a hetero function selected from the group consisting of --O--, --NH--, --N(C.sub.1 -C.sub.6 alkyl-)--, --N(aryl-C.sub.1 -C.sub.6 alkyl-)--, --N(substituted aryl-C.sub.1 -C.sub.6 alkyl-)--, --N(heteroaryl-C.sub.1 -C.sub.6 alkyl-)--, --N(substituted heteroaryl- C.sub.1 -C.sub.6 alkyl-)--, --S-- or --S(O).sub.n --, wherein n is 1 or 2, --C(O)--NH, --C(O)--NR.sup.12 --, wherein R.sup.12 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl substituted with aryl, substituted aryl, heteroaryl, or substituted heteroaryl, --NH--C(O)--, and --NR.sup.12 --C(O)--.