Patent ID: 7678811
Filing Date: 2010-03-16
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) or a salt, prodrug or isolated stereoisomer thereof wherein A is selected from the group consisting of: (i) phenyl, optionally substituted with 1-3 substituents independently selected from the group consisting of R (ii) naphthyl, optionally substituted with 1-3 substituents independently selected from the group consisting of R (iii) 5 and 6 membered monocyclic heteroaryl, having 1-3 heteroatoms independently selected from the group consisting of O, N and S, optionally substituted with 1-3 substituents independently selected from the group consisting of R (iv) 8-10 membered bicyclic heteroaryl, having 1-6 heteroatoms independently selected from the group consisting of O, N and S, optionally substituted with 1-3 substituents independently selected from the group consisting of R (i) phenylene, optionally substituted with 1-3 substituents independently selected from the group consisting of C (ii) naphthylene, optionally substituted with 1-3 substituents independently selected from the group consisting of C (iii) 5 and 6 membered monocyclic heteroaryl-ene, having 1-3 heteroatoms independently selected from the group consisting of O, N and S, optionally substituted with 1-3 substituents independently selected from the group consisting of C (iv) 8-10 membered bicyclic heteroaryl-ene, having 1-6 heteroatoms independently selected from the group consisting of O, N and S, optionally substituted with 1-3 substituents independently selected from the group consisting of C (a) —(CH (b) —(CH (c) —(CH (d) —(CH (e) —(CH (f) —(CH (g) —(CH (h) —(CH (i) —(CH (j) —(CH (k) —(CH (l) —(CH (m) —(CH (n) a single bond; and (o) —(CH wherein m and 1 are integers independently selected from 0-4; (a) pyridine-1-oxide substituted 1 to 3 times by a substituent selected from the group consisting of —C(O)NR (b) quinoline-1-oxide, which is optionally substituted by Z (c) isoquinoline-1-oxide, which is optionally substituted by Z (a) hydrogen, (b) C (c) phenyl, (d) 5-6 membered monocyclic heteroaryl heteroaryl having 1-4 heteroatoms selected from the group consisting of O, N and S or 8-10 membered bicyclic heteroaryl having 1-6 heteroatoms selected from the group consisting of O, N and S, (e) C (f) C (g) up to per-halo substituted C and p and q are integers each independently selected from 0, 1, or 2 subject to the proviso that formula I does not include compounds of formula II: wherein, Y is OR Hal is chlorine or bromine, R R X