Patent ID: 7695683
Filing Date: 2010-04-13
Classification: B01L,G01N,Y10T

Abstract:
1. A method for processing a microfluidic device, the method comprising: providing a flexible substrate including a first plurality of fiducial markings, wherein in a first state, the first plurality of fiducial markings correspond to a first plurality of design locations respectively, the first plurality of design locations having a first spatial relationship with respect to each other; determining a first plurality of actual locations corresponding to the first plurality of fiducial markings respectively, wherein in a second state, one or more of the first plurality of actual locations are shifted from the first plurality of design locations such that the first plurality of actual locations have a second spatial relationship with respect to each other different from the first spatial relationship; processing information associated with the first plurality of actual locations and the first plurality of design locations; determining a transformation between a design space and a measurement space based on at least information associated with the first plurality of actual locations and the first plurality of design locations, the design space associated with the first plurality of design locations, the measurement space associated with the first plurality of actual locations; performing a first alignment to the flexible substrate based on at least information associated with the transformation between the design space and the measurement space; acquiring a first plurality of images of a first fiducial marking; processing information associated with the first plurality of images; performing a second alignment to the flexible substrate based on at least information associated with the first plurality of images; and acquiring a second image of the flexible substrate.