Patent ID: 6525045
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound of the formula (I) wherein:A is a sulphur atom, oxygen atom, >NH or >Nâ€”C1-C4-alkyl; R1 is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, â€”SO2H, â€”SO2â€”C1-C6-alkyl, â€”SOâ€”C1-C6-alkyl, â€”COâ€”C1-C6-alkyl, â€”Oâˆ’, C1-C4-alkyl substituted by a phenyl, â€”C1-C4-alkyl-NR7R8, â€”C1-C4-alkyl-Oâ€”C1-C4-alkyl and, â€”C3-C6-cycloalkyl; R2 and R9 are identical or different and each is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, halogen, â€”NO2, â€”SO2H, â€”SO2â€”C1-C6-alkyl, â€”SOâ€”C1-C6-alkyl, â€”COâ€”C1-C6-alkyl, â€”OH, â€”Oâ€”C1-C6-alkyl, â€”Sâ€”C1-C6-alkyl, â€”C1-C4-alkyl-NR7R8, â€”C1-C4-alkyl-Oâ€”C1-C4-alkyl and â€”C3-C6-cycloalkyl; or, R1 and R2 together form a C2-C6-alkylene bridge; R7 and R8 are identical or different and each is hydrogen or C1-C4-alkyl; and, R3, R4, R5 and R6 are identical or different and each is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, C1-C4-alkyl substituted by a phenyl, halogen, â€”CN, â€”NO2, â€”SO2H, â€”SO3H, â€”SO2â€”C1-C6-alkyl, â€”SOâ€”C1-C6-alkyl, â€”SO2â€”NR7R8, â€”COOH, â€”COâ€”C1-C6-alkyl, â€”Oâ€”COâ€”C1-C4-alkyl, â€”COâ€”Oâ€”C1-C4-alkyl, â€”COâ€”NR7R8, â€”OH, â€”Oâ€”C1-C6-alkyl, â€”Sâ€”C1-C6-alkyl, â€”NR7R8 and aromatic ring systems having 6-10 carbon atoms (wherein one or more hydrogen atoms are optionally substituted by a halogen atom, â€”NO2, â€”SO2H or â€”C1-C4-alkyl); or a pharmacologically acceptable salt thereof.