Patent ID: 6306428
Filing Date: 2001-10-23
Classification: A61K

Abstract:
A laminar time-release pharmaceufical composition comprising:a polymer film containing a pharmaceutically active agent absorbed therein, whereinthe polymer film is rolled or folded to form a laminar structure in which the rolled or folded layers of the polymer film adhere to one another and form successive layers of the laminar structure, and the area of the outer surface of the laminar structure is at most 25% of the surface area of the polymer film, andthe rolled or folded layers adhere to one another so that the laminar structure does not unroll or unfold for a period of at least one hour during a release test according to USP 23, Method A, apparatus 2, at 37.degree. C. and 50 rpm, in artificial gastric juice, andat least 30% of the active agent is released before the laminar structure unrolls or unfolds, andthe laminar time-release pharmaceutical composition dissolves or decomposes under the conditions of the digestive tract.