Patent ID: 6472537
Filing Date: 2002-10-29
Classification: A61F,A61K,A61P,C07D,C07H,C07K,C08G,C12Q

Abstract:
A polyamide comprising:at least three consecutive carboxamide pairs that bind in a sequence-specific manner to an equal number of consecutive DNA base pairs in a duplex DNA sequence, at least one of which consecutive DNA base pairs is an AÂ·T or TÂ·A DNA base pair, wherein said polyamide comprises a 3-hydroxy-N-methylpyrrole (â€œHpâ€ )/N-methylpyrrole (â€œPyâ€ ) carboxamide pair to bind to each TÂ·A base pair in said consecutive DNA base pairs and a Py/Hp carboxamide pair to bind to each AÂ·T DNA base pair in said consecutive DNA base pairs.