Patent ID: 8545875
Filing Date: 2013-10-01
Classification: A61K,A61P,A61Q,Y10S

Abstract:
1. A method for making a nanolipidic particle (NLP) population, comprising the steps of: a. adding a passenger molecule selected from the group consisting of lipophilic and amphipathic passenger molecules to a monophasic precursor solution to form a loaded vehicle population; b. diluting said loaded vehicle population with ethanol to form an NLP loaded particle population, wherein said diluting of said NLP loaded particle population with said ethanol solvent is at a ratio of about 1 part loaded vehicle population to about 20 parts solvent to about 1 part loaded vehicle population to about 0.5 parts solvent, and c. adding an aliquot of said NLP loaded particle population to an aqueous solvent to form an NLP assembly population having a mean particle diameter from about 30 to 200 nm, and wherein the concentration of said ethanol solvent in said NLPs is from about 0.5% to about 14%.