Patent ID: 7943329
Filing Date: 2011-05-17
Classification: A61P,G01N

Abstract:
1. A method for identifying a paired-immunoglobulin-like receptor B/leukocyte immunoglobulin-like receptor, subfamily B (PirB/LILRB) antagonist comprising the steps of: a) contacting a candidate agent with a complex comprising PirB/LILRB and myelin or a myelin-associated protein, or a fragment of myelin, MAG, Nogo or OMgp; b) detecting the ability of said candidate agent to inhibit the binding between PirB/LILRB and said myelin or myelin-associated protein, or said fragment, wherein said PirB/LILRB is selected from the group consisting of LILRB1, LILRB2, LILRB3, and LILRB5; and c) selecting a candidate agent that inhibits said binding, wherein said candidate agent is identified as a PirB/LILRB antagonist if the binding is inhibited.