Patent ID: 6232320
Filing Date: 2001-05-15
Classification: C07D

Abstract:
A compound having Formula I ##STR89##or a pharmaceutically acceptable salt or prodrug thereof, whereF is selected from nitrogen and N.sup.+ -O.sup.- ;E and G arecarbon;Y is carbon; Z isS(O).sub.t where t is 0-2;L.sub.A is selected from(a) --O-- and(b) --S(O).sub.t --;X.sub.A isaryl,where the aryl can be optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from(a) alkyl of one to twenty carbons,(b) alkyl of one to ten carbons substituted with 1, 2, or 3 substituents independently selected from(i) --OR.sub.11 where R.sub.11 is selected fromhydrogen,--C(W)R.sub.12 where R.sub.12 is selected fromalkyl of one to ten carbons,cycloalkyl of three to ten carbons, andaryl,(ii) alkoxy of one to ten carbons optionally substituted with 1 or 2 substituents independently selected fromalkoxy andalkoxyalkoxy,(iii) spiroalkyl of three to ten carbons, and(iv) halo,(c) alkoxy of one to ten carbons optionally substituted with 1 or 2 substituents independently selected from(i) alkoxy and(ii) alkoxyalkoxy,(d) thioalkoxy of one to ten carbons,(e) halo,(f) perfluoroalkyl of one to three carbons,(g) alkenyl of two to ten carbons optionally substituted with 1 or 2 substituents independently selected from(i) --C(W)R.sub.10 where R.sub.10 is selected fromhydrogen,alkyl of one to ten carbons optionally substituted with 1 or 2 substituents independently selected fromaryl andcycloalkyl of three to ten carbons and(ii) --C(W)R.sub.12,(h) --CO.sub.2 R.sub.7 where R.sub.7 is selected from(i) hydrogen and(ii) alkyl of one to ten carbons optionally substituted with 1 or 2 substituents independently selected fromary andcycloalkyl of three to ten carbons,(i) --NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently selected from(i) hydrogen,(ii) alkyl of one to six carbons optionally substituted with 1 or 2 substituents independently selected from--OH,aryl,cycloalkyl of three to ten carbons, and--NR.sub.A R.sub.B where R.sub.A and R.sub.B are independently selected fromhydrogen andalkyl of one to six carbons optionally substituted with 1 or 2 --OH substituents(iii) alkanoyl where the alkyl part is of one to ten carbons,(iv) cycloalkyl of three to ten carbons,(v) alkoxy, and(vi) aryl, where the aryl is substituted with 1 or 2 substituents independently selected fromalkyl of one to six carbons andhalo,(j) aryl,(k) --C(W)R.sub.12,(l) --CHO,(m) --C(O)NR.sub.8 R.sub.9,(n) --CN,(o) --C(W)R.sub.10,(p) ethylenedioxy, and(q) --OCF.sub.3 ;L.sub.B is--C(W)-- where W is selected from O and S;X.sub.B is --NR.sub.17 R.sub.18 where R.sub.17 and R.sub.18 are independently selected from(a) hydrogen,(b) alkyl of one to ten carbons optionally substituted with 1, 2, or 3 substituents independently selected from(i) --OH,(ii) --C(W)R.sub.10,(iii) --NR.sub.A C(.dbd.NR.sub.13)NR.sub.B R.sub.19where R.sub.13 is selected fromhydrogen,--NO.sub.2,--CN, and--OR.sub.14 where R.sub.14 is selected fromhydrogen,aryl, andalkyl of one to ten carbons optionally substituted with 1 or 2 substituents independently selected fromaryl and--C(O)R.sub.15 where R.sub.15 is selected fromhydrogen,--OH,alkoxy, andNR.sub.A R.sub.B andR.sub.19 is selected fromhydrogen,alkyl of one to ten carbons, and--NO.sub.2,(iv) heterocycle,(v) aryl,(vi) halo, and(vii) --NR.sub.A R.sub.B,(c) alkoxy of one to ten carbons,(d) aryl optionally substituted with 1, 2, or 3 substituents independently selected from(i) halo,(ii) alkyl of one to ten carbons,(iii) alkoxy of one to ten carbons, and(iv) perfluoroalkyl of one to three carbons,(e) heterocycle,(f) --NR.sub.A R.sub.B,(g) --C(O)R.sub.20 where R.sub.20 is selected from(i) hydrogen,(ii) alkyl of one to ten carbons,(iii) --OR.sub.12, and(iv) --NR.sub.A R.sub.B,(h) cycloalkyl of three to ten carbons, and(i) --OH;R.sub.1, R.sub.3, and R.sub.4 are independently selected from(a) hydrogen,(b) alkyl of one to six carbons optionally substituted with 1 or 2 substituents independently selected from(i) --OC(O)R.sub.22, where R.sub.22 is selected fromalkyl,alkoxy, and--NR.sub.A R.sub.B,(ii) alkoxy,(iii) --OH,(iv) --NR.sub.A R.sub.B,(v) heterocycle, and(vi) aryl,(c) --CO.sub.2 R.sub.7,(d) --C(O)NR.sub.A R.sub.B,(e) --SR.sub.23 where R.sub.23 is selected from(i) hydrogen,(ii) alkyl of one to six carbons,(iii) aryl optionally substituted with 1 or 2 substituents selected fromalkyl of one to six carbons andhalo,(f) --NR.sub.A R.sub.B,(g) halo,(h) alkoxy of one to six carbons,(i) perfluoroalkyl of one to three carbons,(j) --OH, and(k) heterocycle; andR.sub.2 and R.sub.5 are absent.