Patent ID: 6710125
Filing Date: 2004-03-23
Classification: A61K,A61P,C08G

Abstract:
A method for the preparation of a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer, comprising:providing a water-soluble and non-peptidic polymer having at least one terminal hydroxyl group, the polymer having the structure HO-POLYa-R(POLYb-X)q, wherein POLYa and POLYb are water-soluble and non-peptidic polymer backbones that may be the same or different, R is a central core molecule selected from a polyol or an amino acid, q is an integer from 2 to about 300, and each X is a capping group; and reacting the terminal hydroxyl group of the water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the water-soluble and non-peptidic polymerhaving the structure: