Patent ID: 8039273
Filing Date: 2011-10-18
Classification: A61K,A61P,Y02A

Abstract:
1. A ligand drug conjugate compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: L- is a Ligand unit; -A -A- is an optional Stretcher unit, a is 0, 1 or 2, each —W— is independently a Glucuronide unit having one of the formulae: Su is a Sugar moiety each R is independently hydrogen, a halogen, —CN, or —NO w is an integer ranging from 1 to 2, —Y— is an optional self-immolative spacer unit, y is 0, 1 or 2; p ranges from 1 to 20; -D is a Drug unit and wherein the wavy lines indicates covalent attachment within rest of the compound.