Patent ID: 6399633
Filing Date: 2002-06-04
Classification: A61K,A61P

Abstract:
A method of inhibiting smooth muscle cell proliferation comprising administering to a patient an effective amount of a compound of the formula I, which is less than 70% if the dosage to control tumor growth, whereinR1 is hydrogen, alkyl having 1 to 6 carbon atoms, aryl-C1-C4-alkyl; C1-C6-alkyl substituted by halogen, hydroxy, or carboxy; C3-C6-cycloalkyl, pyridyl, thienyl, C3-C6-cycloalkyl-C1-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl; phenyl, mono- or polysubstituted by halogen, C1-C4-alkyl, C1-C4-alkoxy, hydroxyl, carboxyl, COO-alkyl, CONH2, CONH-alkyl, CON(alkyl)2, nitro, trifluoromethyl, amino, C1-C4-alkylamino, di-C1-C4-alkylamino, or phenyl; naphthyl, carboxyl, â€”CHO, COO-C1-C4-alkyl, a primary amino, alkylamino, aralkylamino, dialkylamino, amido, arylamino, diarylamino, or â€”CH2O-C1-C4-alkyl; R2 is hydrogen, alkyl having 1 to 6 carbon atoms, aryl, nitro, amino, di-C1-C4-alkylamino, a halogen, hydroxyl, alkoxy, â€”COOH, â€”COO-C1-C4-alkyl, â€”CHO, â€”CH2OH or â€”CH2O-C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl; C1-C4-alkyl substituted by halogen, hydroxy or carboxy; hydroxyl, carboxyl, nitro, amino, C1-C4-alkylamino, di-C1-C4-alkylamino, halogen, â€”O-alkyl-C(O)-alkyl, â€”CHO, â€”CH2OH, â€”CH2O-C1-C4-alkyl or R2Nâ€”C(O)â€”Oâ€”, wherein R is H, C1-C6-alkyl, cycloalkyl; or â€”O-alkyl-C(O)-alkyl or aryl; R4 is hydrogen, hydroxyl C1-C4-alkoxy, C1-C4-alkanoyloxy, C1-C4-alkoxycarbonyl, aryloxy, amino, C1-C4-alkylamino, di-C1-C4-alkylamino, or Râ€²2â€”Nâ€”C(O)â€”Oâ€” wherein Râ€² is H, C1-C6-alkyl, cycloalkyl or aryl; R5 is hydrogen, C1-C6-alkyl, aryl-C1-C4 alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, alkylamino, C1-C4-alkanoyl, â€”C(O)â€”O-C1-C4-alkyl or aroyl, where the aryl group in R1, R2, R3, R4, and R5 is unsubstituted phenyl or phenyl that is mono or polysubstituted by halogen, C1-C4-alkyl, C1-C4-alkoxy, hydroxyl, carboxyl, COO-alkyl, CONH2, CONH-alkyl, CON(alkyl)2, nitro, trifluoromethyl, amino, C1-C4-alkylamino, di-C1-C4-alkylamino or phenyl; m is an integer between 0 and 3 and n is 1, or a pharmacologically acceptable acid addition salt thereof.