Patent ID: 6448239
Filing Date: 2002-09-10
Classification: A61P,C07D,C07F

Abstract:
A metallic complex of Formula I: or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein at least one of R1, R2, R3, or R4, is independently selected from a moiety selected from the group consisting of:â€”(CH2)nâ€”X; â€”(CH2)nâ€”Y, â€”CH2CH&boxH;CH2; â€”CH2CH2OCH2CH2OCH2CH2OCH3; â€”CH2CO2CH2CH3; â€”(OCH2CH2)mâ€”X; â€”Y2C(Z1)3, â€ƒwherein: Z1 is CH2OCH2(CH2)nX or CH2OCH2(CH2)nY; â€”(CH2)nC(O)Y2C(Z2)3, â€ƒwherein: Z2 is CH2OCH2CH2C(O)Y2C(Z4)3, Z4 is CH2OCH2CH2Z5, and Z5 is CO2(CH2CH2O)m, â€”COOH; â€”CONH2; â€”CONRâ€²2; â€”OPO3H2; â€”PO3H2;â€”SO3H; â€”NH2; â€”NRâ€²2; or â€”NRâ€²3+; â€”(CH2)nOCH2C(CH2OH)3; â€”(CH2)nOCH2CH(CH2OH)2; â€”(CH2)nOCH2C(CH2OH)2(CH3); â€”(CH2)nOCH2C[CH2OCH2C(CH2OH)3]3; and â€”(CH2)nOCH2C[CH2OCH2C(CH2O[CH2CH2O]mCH2CH2OX)3]3, wherein n is an integer from 1 to 10; m is an integer from 1 to 200; X is â€”COOH; â€”CONH2; â€”CONRâ€²2; â€”OPO3H2; â€”PO3H2; â€”SO3H; â€”NH2; â€”NRâ€²2; or â€”NRâ€²3+, further wherein Râ€² is an alkyl group; Y is â€”OH or â€”(Oâ€”CH2CH2)mâ€”W; where W is â€”OH, or â€”(Oâ€”(CH2CH2)m; Y2 is selected from the group consisting of â€”(CH2)nOâ€”, â€”(CH2)nNHâ€”, and â€”(CH2)nSâ€”; and wherein the remaining R1, R2, R3, and R4 are hydrogen, and M is Mn or Fe.