Patent ID: 7456302
Filing Date: 2008-11-25
Classification: A61P,C07D,Y02P

Abstract:
1. A method for producing a compound of the following general formula (2) or its salt, which comprises reacting a compound of the following formula (1) with an alkali metal permanganate: (in formula (1), the dotted line part between the 6-position and the 7-position of the partial structure of the following formula (1-a): means that the bond of this part may be a double bond; boc means a tert-butoxycarbonyl group; Ac means an acetyl group; Bz means a benzoyl group; R 1 means an alkyl group, a cycloalkyl group, a phenyl group or a monocyclic heterocyclic group, and the alkyl group, the cycloalkyl group, the phenyl group or the monocyclic heterocyclic group may be have one or more substituents selected from a group consisting of a halogen atom, an alkyl group, an alkoxy group, a phenyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an acyl group, an acylamino group and an acyloxy group; R 2 means a hydroxyl group optionally having a protective group); (in formula (2), R 1 , R 2 , boc, Ac and Bz have the same meanings as above).