Patent ID: 9006203
Filing Date: 2015-04-14
Classification: A61P,C12N

Abstract:
1. A method of reducing infiltration of neutrophils into a lung of a subject with an inflammatory lung disease, comprising administering to the subject with the inflammatory lung disease a therapeutically effective amount of a suppressive oligodeoxynucleotide, wherein the suppressive oligodeoxynucleotide comprises from 2 to 4 guanosine-rich sequences, forms a G-tetrad, is at most 100 nucleotides in length, and has a CD value of greater than about 2.9 wherein the oligodeoxynucleotide comprises the nucleic acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 14, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, or SEQ ID NO: 21, thereby reducing the infiltration of neutrophils into the lung of the subject with the inflammatory lung disease.