Patent ID: 6620799
Filing Date: 2003-09-16
Classification: C07F

Abstract:
A compound of the formula wherein n is 0 or 1, m is 0 to 6; p is 1 or 2; R1, R2, R3 and R4 can each independently by hydrogen, C1 to C6 alkyl, hydroxy, OR5, NH2, NR6R7, or halogen; R5, R6 and R7 can each independently be hydrogen, C(O)R8, or C1 to C6 alkyl; and A is a group of the formula wherein R9 represents a phenyl group substituted by one or more halogen atoms, R10 represents hydrogen or CH3, R11 represents hydrogen, or taken together with R10 may represent &boxH;CH2, and R12 represents a thiazolyl group of the formula which may be optionally substituted by one or more groups selected from halogen, &boxH;O, phenyl substituted by one or more groups selected from CN, (C6H4)â€”OCH2CF2CHF2 and CH&boxH;CHâ€”(C6H4)-OCH2CF2CHF2, or phenyl substituted by one or more groups selected from halogen and methylpyrazolyl; or a pharmaceutically acceptable salt thereof.