Patent ID: 6710049
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A compound of Formula I, and its pharmaceutically acceptable salts, enantiomers, diastereomers, or N-oxides,wherein X is selected from the group consisting of CH2, CO, CS, and SO2; Ar is a substituted phenyl group having one to three substituents independently selected from a halogen, C1-C4 alkyl, halogenated lower (C1-C4) alkyl group and halogenated lower (C1-C4) alkoxy group; R1 and R2 are each independently selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkoxy, amino, hydroxy, nitro, cyano, carboxyl, and SO2Râ€² wherein Râ€² is hydrogen, or alkyl; Y is a phenyl group which is unsubstituted or substituted by 1-3 substituents each independently selected from the group consisting of halogen, nitro, amino, cyano, carboxyl, hydroxy, C1-C4 alkyl, C1-C4 alkoxy and SO2Râ€² wherein Râ€² is hydrogen, or alkyl; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl group, C1-C4 alkoxy, nitro, amino, cyano, carboxyl, and SO2Râ€² wherein Râ€² is hydrogen, or alkyl, and X1, X2, Y1, Y2 and Z are independently selected from the group consisting of hydrogen, halogen, nitro, cyano, amino, aryl, C1-C4, alkyl, C1-C4 alkoxy, halogenated lower (C1-C4) alkyl group, halogenated lower (C1-C4)alkoxy group and carboxyl.