Patent ID: 6127533
Filing Date: 2000-10-03
Classification: A61P,C07H,Y02P

Abstract:
A compound having the structure: ##STR6## wherein: B.sub.X is purine or pyrimidine heterocyclic base;each T.sub.1 and T.sub.2 is, independently, OH, a protected hydroxyl group, an activated phosphate group or other groups containing activated phosphorus atoms, a nucleotidyl group, a nucleosidyl group, or an oligonucleotide-derived substituent;L has one of the structures: ##STR7## wherein: m is from 1 to 10;y is from 1 to 10;x is 1;E is N(R.sub.1)(R.sub.2) or N.dbd.C(R.sub.1)(R.sub.2); andeach R.sub.1 and R.sub.2 is, independently, H, C.sub.1 -C.sub.10 alkyl, and an amino protecting group, or R.sub.1 and R.sub.2 together, are an amino protecting group or wherein R.sub.1 and R.sub.2 are joined in a C.sub.4 -C.sub.10 ring structure that can include at least one heteroatom selected from N and O.