Patent ID: 6124294
Filing Date: 2000-09-26
Classification: A61P,C07D

Abstract:
A triazole compound of the formula I ##STR34## where A is a straight-chain or branched C.sub.1 -C.sub.18 -alkylene group, or a straight-chain or branched group consisting of 1 to 18 methylene members and one or two members selected from the group consisting of O, S, NR.sup.3, NR.sup.3 CO, COO, OCO, C.sub.3 -C.sub.6 -cycloalkylene, a double bond and a triple bond,X is a radical of the formula ##STR35## R.sup.1 is H, CO.sub.2 R.sup.3, NR.sup.3 R.sup.4, OR.sup.4, C.sub.3 -C.sub.6 -cycloalkyl or C.sub.1 -C.sub.8 -alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.8 -alkyl or halogen;R.sup.2 has the meanings indicated for R.sup.1 or is CF.sub.3, SR.sup.3, halogen or CN;R.sup.3 is H or C.sub.1 -C.sub.8 -alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.8 -alkyl, phenyl or halogen;R.sup.4 has the meanings indicated for R.sup.3 or is COR.sup.3 or CO.sub.2 R.sup.3 ;Ar is 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl or 6-pyrimidyl, where Ar may carry from one to four substituents selected from the group consisting of OR.sup.4, C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, halogen, CN, CO.sub.2 R.sup.3, NO.sub.2, SO.sub.2 R.sup.3, SO.sub.3 R.sup.3, NR.sup.3 R.sup.4, SO.sub.2 NR.sup.3 R.sup.4, SR.sup.3, CF.sub.3, CHF.sub.2, C.sub.3 -C.sub.6 -cycloalkyl and phenyl, where the carbocyclic ring may be unsubstituted or substituted by C.sub.1 -C.sub.8 -alkyl, halogen, OC.sub.1 -C.sub.8 -alkyl, OH, NO.sub.2 or CF.sub.3 andor a salt thereof with physiologically tolerated acid.