Patent ID: 7893112
Filing Date: 2011-02-22
Classification: A61K,A61P,C07C

Abstract:
1. A method for ameliorating a disease selected from neuropathic pain, Hashimoto's thyroiditis, osteoarthritis, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, psoriasis, pemphigus vulgaris, Graves' disease, myasthenia gravis, systemic lupus erythemotasus, asthma, inflammatory pain or atherosclerosis in an animal mediated by Cathepsin S, which method comprises administering to the animal a pharmaceutical composition comprising a compound of Formula (I): in admixture with one or more suitable excipients, wherein R wherein the aromatic or alicyclic ring in the groups attached to cycloalkylene is optionally substituted with one, two, or three substituents independently selected from alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxycarbonyl, alkoxy, hydroxy, haloalkoxy, halo, carboxy, alkoxycarbonyl, amino, monsubstituted amino, disubstituted amino, or acyl; R R R R R R Y is -alkylene-, wherein the alkylene group is optionally substituted with one to six fluoro atoms; and Z is a direct bond or -alkylene-, wherein the alkylene portion is optionally substituted with one to six fluoro atoms.