Patent ID: 8846069
Filing Date: 2014-09-30
Classification: A61F,A61L,A61P

Abstract:
1. A medical article comprising an implantable substrate having a coating, the coating including a polymer comprising a carboxylated poly(lactic acid), or a block-copolymer having at least one moiety comprising a carboxylated poly(lactic acid), wherein the carboxylated poly(lactic acid) is of formula (D): wherein X is selected from the group consisting of O, NH, and S; R is phenyl; and n is an integer; wherein the molecular weight of the carboxylated poly(lactic acid) is about 1,000 to about 20,000 Daltons; wherein the block-copolymer is a diblock-copolymer or a triblock-copolymer comprising at least one biocompatible moiety, wherein the biocompatible moiety is selected from a group consisting of poly(tetramethylene glycol), β-butyrolactone, δ-valerolactone, poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid) and salts thereof, poly(styrene sulfonate), sulfonated dextran, poly(tyrosine carbonate), hyaluronic acid, copolymers of poly(ethylene glycol) with hyaluronic acid, heparin, copolymers of polyethylene glycol with heparin, a graft copolymer of poly(L-lysine) and poly(ethylene glycol).