Patent ID: 6984634
Filing Date: 2006-01-10
Classification: A61K,C07C,C07D,C07K

Abstract:
1. A compound of formula (I): wherein: R X is hydroxy; Z is a group of formula -M-Q wherein a′ and b′ are independently 0 or 1, wherein at least one of a′ and b′ is 1; R R R R R D′ is a pharmacologically active chemical compound containing at least one carboxylic acid group and at least one moiety selected from the group consisting of a primary amino group, a secondary amino group or a hydroxyl group; with the provisos that D′ is not a GABA analog; L-Dopa, an L-aromatic amino acid decarboxylase inhibitor, a catechol O-methyl transferase inhibitor or derivatives thereof; a naturally occuring α-amino acid or an ester or carboxamide of a naturally occuring α-amino acid; a polypeptide derived from a linear oligopeptide containing at least 3 α-amino acids; an oligonucleotide; a cyclophane derivative, a diethylenetriaminopentaacetate derivative, or paramagnetic ion chelates thereof; 5-de-O-methylsporaricin; a bis-(2-choroethyl)amino containing nitrogen mustard; an HMG-CoA reductase inhibitor; a proline hydroxylase inhibitor; or a steriod containing the carbon substructures of the following formulae; or a pharmaceutically acceptable salt thereof.