Patent ID: 7026460
Filing Date: 2006-04-11
Classification: C07K

Abstract:
1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide comprising an amino acid sequence that is identical to the amino acid sequence of SEQ ID NO:91 except for the presence of at least one amino acid change selected from the group consisting of: (a) a phenylalanine changed to valine, leucine, isoleucine, or methionine at position 31; (b) a glutamine changed to lysine, arginine or histidine at position 41; (c) a threonine changed to valine, leucine, isoleucine, or methionine at position 52; (d) a threonine changed to aspartic acid, glutamic acid, asparagine or glutamine at position 52; (e) a cysteine changed to lysine, arginine or histidine at position 73; (f) a proline changed to serine, threonine or cysteine at position 101; (g) a proline changed to aspartic acid, glutamic acid, asparagine or glutamine at position 101; (h) a valine changed to leucine, isoleucine, or methionine at position 111; (i) a serine changed to valine, leucine, isoleucine, or methionine at position 133; (j) a glutamic acid changed to valine, leucine, isoleucine, or methionine at position 141; (k) a glutamic acid changed to lysine, arginine or histidine at position 141; (l) a cysteine changed to phenylalanine, tyrosine or tryptophan at position 153; (m) a cysteine changed to lysine, arginine or histidine at position 153; (n) a threonine changed to glycine, alanine or proline at position 281; (o) a asparagine changed to valine, leucine, isoleucine, or methionine at position 367; (p) a asparagine changed to phenylalanine, tyrosine or tryptopthan at position 367; (q) a proline changed to serine, threonine or cysteine at position 389; and (r) a proline changed to valine, leucine, isoleucine, or methionine at position 389.