Patent ID: 9095627
Filing Date: 2015-08-04
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating or preventing pain in a patient in need thereof, which comprises administering an effective amount of a composition comprising a pharmaceutically acceptable excipient and a compound of formula III: or a compound of formula VI: wherein X is hydromorphone, morphine or oxymorphone; R R the A ring is a heterocyclic 5 to 12-membered ring; each Y is independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, acyl, substituted acyl, carboxyl, alkoxycarbonyl, substituted alkoxycarbonyl, aminoacyl, substituted aminoacyl, amino, substituted amino, acylamino, substituted acylamino, and cyano; c is a number from zero to 3; each R each R R a is an integer from one to 8; provided that when a is one, the A ring is a heterocyclic 6 to 12-membered ring; and when the A ring is a heterocyclic 5-membered ring, then a is an integer from 2 to 8; each R R each R b is a number from zero to 100; and R or a salt, hydrate or solvate thereof.