Patent ID: 6313311
Filing Date: 2001-11-06
Classification: A61P,C07D

Abstract:
An imidazole compound of formula I ##STR22##n is 1R.sub.1 is hydrogen or C.sub.1 -C.sub.4 -alkylR.sub.2 is hydrogen or R.sub.2 and R.sub.3 together form a double bondR.sub.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl or R.sub.2 and R.sub.3 together form a double bondR.sub.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, hydroxy or C.sub.1 -C.sub.4 -alkoxyR.sub.5 is hydrogen or C.sub.1 -C.sub.4 -alkyl or R.sub.4 and R.sub.5 together with the carbon atom to which they are attached form a carbonyl groupR.sub.6, R.sub.7 and R.sub.8 are each the same or different and are independently hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.2 -C.sub.4 -alkenyl, C.sub.3 -C.sub.7 -cycloalkyl, hydroxy, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -hydroxyalkyl, thiol C.sub.1-4 -alkylthio, C.sub.1-4 -alkylthiol, halogen, trifluoromethyl, nitro, unsubstituted amino, or amino substituted with C.sub.1 -C.sub.4 -alkylX is --CHR.sub.9 --(CHR.sub.10).sub.m --m is 0 or 1and R.sub.9 and R.sub.10 are each the same or different and are independently hydrogen or C.sub.1 -C.sub.4 -alkyl;or a pharmaceutically acceptable ester or salt thereof.