Patent ID: 8598179
Filing Date: 2013-12-03
Classification: A61P,C07D

Abstract:
1. A compound of formula I, wherein D is selected from phenyl, naphthyl, and thiazolyl, wherein said phenyl or naphthyl residue is unsubstituted or substituted 1, 2, 3 or 4 times by R4, Q is 1) -(C J is 1) hydrogen atom, Z is 1) —(C 2) —(C 3) —(C A is 1) a covalent bond, 2) —(C 3) —(C 4) —(C B is 6) —(C 7) —(C 8) —(C and each of B is further unsubstituted or mono-, di- or trisubstituted independently of one another by R3, V is piperazinyl, G is 1) a covalent bond, 2) —(C 3) —(C 4) —(C M is 1) a hydrogen atom, 2) —(C 3) —C(O)—O—R12, 4) —(C 5) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, or 6) heterocyclyl selected from benzoisoxazolyl, furanyl, isoxazolyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, thiadiazolyl or thiazolyl, wherein heterocyclyl is unsubstituted or substituted by R14, R1 is hydrogen atom, R2 is hydrogen atom, R3 is 1) hydrogen atom, 2) halogen, 3) —(C 4) —(C a) hydrogen atom, b) —(C c) —(C d) —CF e) —CHF 5) —(C R4 is 1) hydrogen atom, 2) —(C 3) —(C 4) halogen, 5) —(C 6) —CN, 7) —NO 8) —S—CH 9) —SO R10 is hydrogen atom, —(C R11 and R12 are independently of one another identical or different and are 1) hydrogen atom, 2) —(C 3) —(C 4) —(C R13 is hydrogen atom, —(C R14 is hydrogen atom, halogen, —OH, ═O, —NO wherein R18 is hydrogen atom, —(C R20 is hydrogen atom, —(C in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.