Patent ID: 7319023
Filing Date: 2008-01-15
Classification: C12Q,Y10S

Abstract:
1. A method for detecting a human cell proliferative disorder associated with a hypermutable target nucleic acid comprising: isolating the nucleic acid present in a specimen of a human and detecting the presence of the hypermutable target nucleic acid; wherein the proliferative disorder is selected from the group consisting of: head and neck small cell carcinoma (SCC), non small cell lung carcinoma, small cell lung carcinoma, and bladder transitional cell carcinoma (TCC); and wherein the hypermutable target nucleic acid is 11 or 15 repeats of the tetranucleotide sequence AAAG in the chromosome 6 microsatellite locus ACTBP2; comparing length of the hypermutable target nucleic acid in the specimen of the human to length of the hypermutable target nucleic acid in a control specimen, wherein a variation in length of the hypermutable target nucleic acid between the specimen of the human and the control specimen indicates a cell proliferative disorder.