Patent ID: 8293947
Filing Date: 2012-10-23
Classification: A61P,C07C,Y02P

Abstract:
1. A method for the preparation of a compound of formula (Ia) or (Ib) wherein a compound of formula (II) a) is alkylated with an alkylating reagent of the formula X—(CH where X is Cl, Br, I, mesyloxy or tosyloxy, and Pr is a protecting group, to give a compound of formula (III) which is subjected to removal of the protecting group Pr to give the compound of formula (Ia), or b) is alkylated with an alkylating reagent of the formula X—(CH which is subjected to removal of the protecting group Pr to give the compound of formula (Ib), or c) is alkylated with an alkylating reagent of the formula X—CH and the ester is reduced to give the compound of formula (Ib).