Patent ID: 8754215
Filing Date: 2014-06-17
Classification: C07C,C07D

Abstract:
1. A process for the preparation of 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide, which comprises: a) condensation of β-phenylethylamine with chloroacetyl chloride in the presence of a solvent and a base to obtain 2-chloro-N-phenethylacetamide; b) condensation of benzylamine with chloroacetaldehyde dimethylacetal in the presence of water and a base to obtain N-benzyl-2,2-dimethoxyethanamine; c) condensation of 2-chloro-N-phenethylacetamide prepared in step a) with N-benzyl-2,2-dimethoxyethanamine of formula VI prepared in step b) in the presence of water and a base to obtain 2-[(2,2-dimethoxyethyl)benzylamino]-N-phenethylacetamide; and d) reduction of 2-[(2,2-dimethoxyethyl)benzylamino]-N-phenethylacetamide using a reducing agent and a solvent in the presence of hydrogen to obtain 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide.