Patent ID: 6362194
Filing Date: 2002-03-26
Classification: A61K,G01N,Y10S

Abstract:
A method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of said bimodally-acting opioid agonist, comprisingadministering to a subject an analgesic or sub-analgesic amount of a bimodally-acting opioid agonist selected from the group consisting of morphine, codeine, fentanyl analogs, buprenorphine, methadone, enkephalins, dynorphins, and endorphins, and an amount of an excitatory opioid receptor antagonist selected from the group consisting of naloxone and naltrexone effective to enhance the analgesic potency of said bimodally-acting opioid agonist and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of said bimodally-acting opioid agonist.