Patent ID: 7919119
Filing Date: 2011-04-05
Classification: A61K,A61P

Abstract:
1. A method for making, a pharmaceutical composition comprising a porous matrix formed of at least one hydrophilic or hydrophobic excipient and microparticles of a drug, wherein the microparticles have a mean diameter between about 0.1 and 5 μm and a total surface area greater than about 0.5 m 2 /mL, and wherein the dry porous matrix is in a dry powder form having is TAP density less than or equal to 1.0 g/mL and having a total surface area of greater than or equal to 0.2 m 2 /g comprising (a) dissolving a drug in a volatile solvent to form a drug solution. (b) combining at least one volatile solid pore forming agent with the drug solution to form an emulsion, suspension, or second solution, (c) incorporating at least one excipient into the emulsion, suspension, or second solution. wherein the excipient is selected from the group consisting of hydrophobic and hydrophilic excipients which enhance dissolution rate, which stabilize drug in amorphous form by preventing crystallization, and which stabilize drug in crystalline form by inhibiting crystal growth, and (d) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug and excipient.