Patent ID: 6274757
Filing Date: 2001-08-14
Classification: A61P,C07D

Abstract:
A process for preparing a compound of the formula ##STR8##where R.sub.1 is di- or polysubstituted aralkyl or aralkenyl; R.sub.2 is alkyl or alkenyl; provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy; A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, or aromatic dicarbonyl; n is 0, 1, or 2; m is 0, 1, or 2; p is 0, 1, or 2; R.sub.3 is H, CH.sub.3, or lower alkyl; R.sub.4 is H, CH.sub.3, or lower alkyl; R.sub.3 and R.sub.4 together can also be --(CH.sub.2).sub.g --, --CH.dbd.CH--, --(CH.sub.2).sub.h --O--(CH.sub.2).sub.k --, or --(CH.sub.2).sub.h --S--(CH.sub.2).sub.k --, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2; and X is a pharmaceutically acceptable anion;which comprises reacting a compound of the formula ##STR9##with a compound of the formulaCl--A--Clto produce a first reaction product of the formula ##STR10##and reacting said first reaction product with a compound of the formulaR.sub.1 Xto produce a second reaction product of the formula ##STR11##