Patent ID: 7304156
Filing Date: 2007-12-04
Classification: A61P,C07D

Abstract:
1. A process for preparing a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound having the formula (3): in which R is selected from C 1-6 alkyl, C 3-6 cycloalkyl, phenyl(C 1-3 )alkyl, phenyl and tolyl which comprises the steps of: reacting a hydroxypyrimidine compound having the formula (1): in which R is the same as above, with an organic sulfonyl halide having the formula (2): in which R′ is selected from C 1-6 alkyl, optionally substituted by one or more fluorines; and phenyl, optionally substituted by one or more C 1-6 alkyl C 1-6 alkoxy, halo or nitro and X is a halogen atom, or an organic sulfonic anhydride having the formula (2a): in which R′ has the same meaning as above, and reacting the resulting reaction product with N-methyl-N-methanesulfonamide, wherein both of the reaction of the hydroxypyrimidine compound with the organic sulfonyl halide or the organic sulfonic anhydride and the reaction of the resulting reaction product with N-methyl-N-methanesulfonamide are performed in the presence of a base.