Patent ID: 6110729
Filing Date: 2000-08-29
Classification: A61P,C07C,C12P

Abstract:
A method of preparing an optically active compound of Formula VIII ##STR16## where * is an optically active chiral center, comprising treating a racemic compound of Formula VII with a stereoselective hydrolase enzyme ##STR17## wherein: R.sup.9 is selected from (C.sub.1 -C.sub.10)alkyl, aryl and aryl(C.sub.1 -C.sub.3)alkyl, and each R.sup.9 is substituted with 0, 1 or more substituents independently selected from hydroxy, halogen, (C.sub.1 -C.sub.4)alkoxy, cyano, (C.sub.1 -C.sub.4)alkylamino and (C.sub.1 -C.sub.4)dialkylamino, andA is selected from CN, COH, CH(OR.sup.3).sub.2, COR.sup.3, COOR.sup.3, CONH.sub.2, CONHR.sup.3 and CON(R.sup.3).sub.2, wherein R.sup.3, at each occurrence, is independently selected from (C.sub.1 -C.sub.10)alkyl, aryl, and aryl(C.sub.1 -C.sub.3)alkyl and each R.sup.3 may be optionally substituted with substituents selected from hydroxy, halogen, (C.sub.1 -C.sub.4)alkoxy, cyano, (C.sub.1 -C.sub.4)alkylamino and (C.sub.1 -C.sub.4)dialkylamino, andisolating compound of Formula VIII.