Patent ID: 8975447
Filing Date: 2015-03-10
Classification: C07B,C07C

Abstract:
1. A process for making a compound of formula (I): the process comprising allowing a compound of formula (II): to react with a compound of formula (III): in the presence of a tertiary alcohol and a compound of formula (IV): to provide the compound of formula (I): wherein m is 0, 1 or 2; each R 1 is independently selected from —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl; wherein each of the —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl of said R 1 is optionally independently substituted with one to three groups selected from halo, —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl; R 2 is a leaving group selected from chloro, bromo, iodo, methoxy, arylsulfonyloxy and trifluoromethanesulfonyloxy; and R 3 and R 4 are each independently absent or a group selected from halo, —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, —(C 3 -C 6 )cycloalkyl, -(4- to 11-membered)heterocycloalkyl, —(C 6 -C 10 )aryl, and -(5- to 11-membered)heteroaryl; and X 1 and X 2 are each independently fluoro, chloro or bromo.