Patent ID: 8957209
Filing Date: 2015-02-17
Classification: C07D

Abstract:
1. A synthesis method for preparation of tiotropium bromide, said method comprising: a) reacting compound 1A or a salt thereof with compound 2A, wherein R is selected from the group consisting of hydroxy, methoxy, ethoxy, tertiary butoxide, phenoxy, O—N-succinimide, O—N-phatalimide, phenyloxy, nitrophenyloxy, pentafluorophenyloxy, vinyloxy, and —S-methyl, —S-ethyl, —S-phenyl, to produce compound 3A, b) quaternizing compound 3A under conditions that do not require a purification procedure to produce compound 4A, and c) oxidizing compound 4A to produce compound 5A,  (tiotropium bromide).