Patent ID: 6569383
Filing Date: 2003-05-27
Classification: G01N,Y10T

Abstract:
A device comprising:a microfluidic chip for analyzing an analyte in a complex solution by separating the analyte from the complex solution, followed by modification of the separated analyte and analysis of the modified analyte, said microfluidic chip having: at least one port for introducing the complex solution into said microfluidic chip, at least one separation site fluidically connected to said port, which has surface immobilized affinants for separating the analyte from the complex solution, in fluid communication along a surface pathway, with at least one modification site, which has surface immobilized modifiers for modifying the separated analyte by digesting or processing the separated analyte into modified analyte fragments, wherein the microfluidic chip is employed as a sampling stage for mass spectrometric analysis of the modified analyte fragments.