Patent ID: 8691805
Filing Date: 2014-04-08
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) selected from the group consisting of: a compound wherein Y is furan-2-yl, Z is 4-biphenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-biphenyl, and s is 0; a compound wherein Y is thien-2-yl, Z is 4-biphenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-4-methylthien-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(thien-2-yl)-4-methylthien-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-methylphenyl)-4-methylthien-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenyl)-4-methylthien-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(thien-2-yl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(thien-2-yl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(2-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(2-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-cyanophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-chlorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3,5-dichlorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-bromophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(4-bromophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3,4-dichlorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-methylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-fluoro-6-methylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(2,4-difluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-methoxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(benzo[1,3]dioxal-5-yl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(naphth-2-yl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-nitrophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-cyanomethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-methylsulfonylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-methylcarbonylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-formylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-hydroxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-chloro-3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-dimethylaminosulfonylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4,5-difluoro-2-methoxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-formyl-4-methoxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-hydroxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-methylsulfonylaminophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-t-butoxycarbonylaminophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-isobutyloxyphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-(2-cyanoethenyl)phenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(2-methoxycarbonylethenyl)phenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3,4-dichlorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-aminophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-fluoro-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-fluoro-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methoxy-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methoxy-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-chloro-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-chloro-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-4-(4-chloro-3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-4-(4-chloro-3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methoxy-4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methoxy-4-(4-chloro-3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-chloro-4-(3-chloro-4-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-chloro-4-(4-chloro-3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is 5-chlorofuran-2-yl, Z is 4-biphenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenyl)-benzoxazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-benzoxazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-benzoxazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-phenyl-naphth-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-phenyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-phenyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-(3-trifluoromethylphenyl)-4-methyl-thiazol-5-yl, and s is 0; 0 a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-chlorophenyl)-4-methylthiazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-chlorophenyl)-4-methylthiazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-phenyl-3-methyl-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3,4,5-trifluoro-phenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl, and s is 0; a compound wherein Y is cyclopropyl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-5-phenyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-fluorophenyl)-5-methyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-7-(3-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-(2,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-(6-trifluoromethylpyridin-3-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-6-(4-trifluoromethylphenyl)-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-methyl-5-(3-fluorophenyl)-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-7-(3-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is 4-(3-trifluoromethylphenyl)-phenyl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethoxyphenyl)-3-methyl-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-6-fluoro-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(5-trifluoromethylthien-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(6-methoxypyridin-3-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is (2-methyl-4-phenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-(4-fluorophenyl)-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-7-methyl-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3,4-difluorophenyl)-benzoxazol-6-yl, and s is 0; a compound wherein Y is 5-chloro-furan-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-fluorophenyl)-thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-methyl-3-(3-trifluoromethylphenyl)-indol-6-yl, and s is 0; a compound wherein Y is oxazol-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethyl-phenyl)-quinazolin-7-yl, and s is 0; a compound wherein Y is 4-bromothien-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-3-methyl-indol-5-yl, and s is 0; a compound wherein Y is 1-(4-fluorophenyl)-3-methyl-indol-5-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4-methoxyphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-5-(4-trifluoromethylphenyl)-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is oxazol-4-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-trifluoromethyl-6-phenylbenzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-fluorophenyl)-5-methyl-thien-2-yl, and s is 0; a compound wherein Y is isothiazol-5-yl, Z is 1-(4-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-6-phenylbenzothien-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(3-trifluoromethylphenyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-7-(4-fluorophenyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-phenyl-5-fluoro-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(6-methyl-pyridin-3-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3,4-difluorophenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2-methoxypyridin-4-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-fluoro-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2-cyanophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-fluorophenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-7-fluoro-indol-5-yl, and s is 0; a compound wherein Y is 2,2-difluoro-cyclopropyl, Z is 4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-cyanophenyl)-indol-5-yl, and s is 0; a compound wherein Y is isothiazol-5-yl, Z is 3-methyl-4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-methoxy-4-cyanophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(2,4-difluorophenyl)phenyl, and s is 0; a compound wherein Y is isoxazol-5-yl, Z is 4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2,3-diphenyl-1H-indol-6-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-(4-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(5-fluoropyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-phenyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3,5-difluorophenyl)-pyrazol-1-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(3-fluorophenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-benzothiazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(6-methyl-pyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(pyridin-4-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-methyl-pyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3,4-difluorophenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-phenyl-quinazolin-7-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-fluorophenyl)-benzothiazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-phenyl-indol-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-cyanophenyl)-indol-5-yl, and s is 0; a compound wherein Y is 1-(3,4-difluorophenyl)-3-methyl-indol-5-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(pyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is 4-(5-trifluoromethylthien-2-yl)-phenyl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-phenyl-indazol-5-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 4-(5-trifluoromethylthien-2-yl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(2,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is furan-3-yl, Z is biphenyl-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-phenyl-benzoxazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(3-fluorophenyl)-indol-6-yl, and s is 0; a compound wherein Y is 5-chloro-thien-2-yl, Z is 4-(3-trifluoromethylphenyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-phenyl-5-trifluoromethyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-methyl-(2-(4-fluorophenyl)-thiazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-benxoxazol-7-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-phenyl-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-phenyl-4-methoxy-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-fluoro-3-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(pyrimidin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-(2-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-phenyl-benzothiazol-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-chloro-5-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(pyrimidin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-fluoro-5-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-chloro-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-3-phenyl-phenyl, and s is 0; a compound wherein Y is biphenyl-4-yl, Z is isothiazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-(3-chlorophenyl)-benzoxazol-7-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-(3-fluorophenyl)-benzoxazol-7-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-3H-benzimidazol-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-(4-fluorophenyl)-benzoxazol-7-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(6-trifluoromethylpyridin-3-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(5-chloropyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(5-trifluoromethylpyridin-2-yl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-5-phenyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-phenyl-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4-fluorophenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(4-fluorophenyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(3-fluorophenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-indol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenyl)-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-chloro-4-phenyl-phenyl, and s is 0; a compound wherein Y is 1H-pyrrol-3-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-phenyl-thiazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-(4-chlorophenyl)-4,5,6,7-tetrahydro-indazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(2-chlorophenyl)-thiazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(2,4-dichlorophenyl)-thiazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-(3-trifluoromethylphenyl)-5,6-dihydro-4H-cyclopentapyrazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(3,4-dichlorophenyl)-thiazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(3-trifluoromethylphenyl)-thiazol-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-(4-chlorophenyl)-pyrazol-1-yl)-phenyl, and s is 0; a compound wherein Y is 5-bromofuran-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is 5-fluoro-thien-2-yl, Z is 4-(3-trifluoromethylphenyl)-phenyl, and s is 0; a compound wherein Y is 1-(4-trifluoromethylphenyl)-indol-5-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is 1-(4-trifluoromethylphenyl)-indol-5-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is 1-(4-trifluoromethylphenyl)-indol-5-yl, Z is 1H-pyrrol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4-trifluoromethylphenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(3-trifluoromethylphenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-phenyl-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(3-trifluoromethylphenyl)-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-(4-trifluoromethylphenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-(3-trifluoromethylphenyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-phenyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(4-trifluoromethylphenyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-4-fluoro-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-6-fluoro-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-7-fluoro-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenyl)-5-methyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(4-trifluoromethylphenyl)-4-methyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(4-fluorophenyl)-4-methyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-(3-trifluoromethylphenyl)-4-methyl-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-7-methyl-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-phenyl-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(5-trifluoromethylthien-2-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-3-chloro-indol-5-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-(3,4-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3,4,5-trifluoro-phenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-fluorophenyl)-3-methyl-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethoxyphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(4-trifluoromethoxyphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3,5-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-fluoro-4-chlorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2,5-difluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethoxyphenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-cyano-3-methylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethoxyphenyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methoxy-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-5-phenyl-furan-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-trifluoromethyl-5-phenyl-furan-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-fluoro-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-4-phenyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylphenyl)-4-methyl-thiazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3-trifluoromethylphenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(1-phenylethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-methylindol-1-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-4-chloro-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-cyano-4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-(3-trifluoromethoxyphenyl)-indazol-5-yl, and s is 0; a compound wherein Y is 5-chloro-furan-2-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is oxazol-2-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is 5-fluoro-thien-2-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; a compound wherein Y is oxazol-4-yl, Z is 1-(4-fluorophenyl)-indol-5-yl, and s is 0; or a pharmaceutically acceptable salt form thereof.