Patent ID: 6455539
Filing Date: 2002-09-24
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (1): wherein R1 is a group ar1ar2alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; Ar2 is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; and Alk is a chain â€”CH2â€”CH(R)â€”, â€”CH&boxH;C(R)â€”, in which R is a carboxylic acid (â€”CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic chain; R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.