Patent ID: 8889117
Filing Date: 2014-11-18
Classification: A61K,A61P,B82Y

Abstract:
1. A vaccine composition for inducing an immune response comprising an antigen selected from the group consisting of viral, bacterial, parasitic, allergen, toxoid, tumor-specific and tumor-associated antigens and an endosome-disrupting agent encapsulated in, attached on, or incorporated into a polymeric nanoparticle, wherein the endosome-disrupting agent is activated at the low pH of the endosome to enhance penetration into the cytosol of molecules in the endosome, the polymeric nanoparticle comprising on its surface a functional element comprising a dendritic cell or epithelial cell targeting molecule that specifically targets an internalizing surface molecule, the polymeric nanoparticle optionally comprising an adaptor element bound to or incorporated in the nanoparticle, wherein the functional element is bound to the nanoparticle by the adaptor element.