Patent ID: 7846893
Filing Date: 2010-12-07
Classification: A61K,A61P

Abstract:
1. A monodisperse macromolecular conjugate composition for in-vivo delivery of a therapeutic agent comprising a peptidic carrier reversibly or irreversibly conjugated with: (a) one or more effectors and (b) one or more therapeutic agents, wherein said peptidic carrier comprises at least two different orthogonal pendant reactive groups each for specific attachment of a predetermined effector or therapeutic agent and at least one effector or therapeutic agent is attached to at least one of said pendant reactive groups on said peptidic carrier via a water-soluble polymer, and wherein said peptidic carrier comprises an amino acid sequence selected from the group consisting of: Cys-beta Ala-Lys (SEQ ID NO: 1); Cys-(beta Ala-Lys) 6 (SEQ ID NO: 2); Acetyl-Cys-(beta Ala-beta Ala-Lys) 2 -Amide (SEQ ID NO: 3); Acetyl-Cys-(beta Ala-(beta Ala-Lys)