Patent ID: 8999685
Filing Date: 2015-04-07
Classification: C07K,C12N,C12P

Abstract:
1. A filamentous fungal host cell comprising a heterologous polynucleotide encoding a malic acid transporter, wherein the malic acid transporter is selected from the group consisting of: (a) a malic acid transporter comprising an amino acid sequence having at least 95% sequence identity with SEQ ID NO: 34; (b) a malic acid transporter encoded by a polynucleotide that hybridizes under very high stringency conditions with the full-length complementary strand to SEQ ID NO: 33; and (c) a malic acid transporter encoded by a polynucleotide comprising a nucleotide sequence having at least 95% sequence identity with SEQ ID NO: 33; and wherein the filamentous fungal host cell is capable of secreting increased levels of malic acid compared to the filamentous fungal host cell without the heterologous polynucleotide encoding the malic acid transporter when cultivated under the same conditions.