Patent ID: 6825045
Filing Date: 2004-11-30
Classification: G01N,H01J,Y10T

Abstract:
A method for desorption and ionization of analytes, comprising the steps of:a. preparing a sample having analytes and a polyacrylamide medium aving at least one component; b. selecting a resonant vibrational mode of at least one component of e medium; c. selecting a laser tuned to emit light substantially at the wavelength f the selected vibrational mode; and d. irradiating the sample with laser light to cause medium ablation an desorption and ionization of the analytes, wherein the preparing step comprises a step of stabilizing the sample for ompatibility with high-vacuum conditions, wherein the stabilizing step comprises a step of freezing the sample at a sufficiently low temperature so that at least part of the sample has a phase transition.