Patent ID: 8133983
Filing Date: 2012-03-13
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A human binding molecule, which is isolated, consisting essentially of an agonistic binding molecule able to bind to and stimulate a human OX40-receptor, wherein the binding molecule has a synergistic stimulatory effect when co-incubated with OX40-ligand, and wherein the binding molecule comprises a heavy chain variable region comprising: the variable region of SEQ ID NO:25, or a molecule that is at least 97% homologous thereto, and a light chain variable region comprising the variable region of SEQ ID NO: 29, or a molecule that is at least 97% homologous thereto; or the variable region of SEQ ID NO:28, or a molecule that is at least 97% homologous thereto, and a light chain variable region comprising the variable region of SEQ ID NO: 32 or a molecule that is at least 97% homologous thereto.