Patent ID: 6218129
Filing Date: 2001-04-17
Classification: G01N

Abstract:
A highly sensitive method of diagnosing inflammatory bowel disease (IBD) in an individual, comprising the steps of:(a) isolating a sample from said individual;(b) determining by non-histological means whether said sample is positive for anti-neutrophil cytoplasmic antibodies (ANCA);(c) determining whether said sample is positive for anti-Saccharomyces cerevisiae immunoglobulin A (ASCA-IgA);(d) determining whether said sample is positive for anti-Saccharomyces cerevisiae immunoglobulin G (ASCA-IgG); and(e) diagnosing said individual as having IBD when said sample is positive for ANCA, ASCA-IgA or ASCA-IgG, and diagnosing said individual as not having IBD when said sample is negative for ANCA, ASCA-IgA and ASCA-IgG,provided that said method does not include histological analysis of neutrophils.