Patent ID: 6093547
Filing Date: 2000-07-25
Classification: C07K,Y10S

Abstract:
A method of identifying a morphogen analog, comprising the steps of:(a) selecting a candidate morphogen analog;(b) exposing said candidate morphogen analog to a composition comprising a polypeptide encoded by the DNA shown in SEQ ID NO: 1 or an allelic or species variant thereof, wherein the polypeptide, or allelic or species variant thereof, has binding specificity for OP-1 or BMP-2 while not substantially binding to TGF-.beta. or activin and wherein the polypeptide, or allelic or species variant thereof, is about 500 amino acids and has a molecular weight of about 58-90 kDa; and(c) determining whether said candidate morphogen analog from step (b) binds said polypeptide, or allelic or species variant thereof,wherein a candidate morphogen analog that binds said polypeptide, or allelic or species variant thereof, is identified as a morphogen analog.