Patent ID: 6545174
Filing Date: 2003-04-08
Classification: A61K,A61Q,C07C

Abstract:
A 4,4-diarylbutadiene of the formula Ia, where the diene system has the Z,Z; Z,E; E,Z or E,E configuration or a mixture thereof, and where the variables independently of one another have the following meanings:R1 and R2 are hydrogen, or are selected from the group consisting of C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl, hetaryl, any of which may be unsubstituted or substituted, and substituents which confer solubility in water and are selected from the group consisting of carboxylate, sulfonate, and ammonium residues; R3 is COOR5 or CONR5R6; R4 is COOR6 or CONR5R6; R5 and R6 are hydrogen, or are selected from the group consisting of C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C7-C10-bicycloalkyl, C3-C10-cycloalkenyl, C7-C10-bicycloalkenyl, aryl, and hetaryl, any of which may be unsubstituted or substituted; n is 1 to 3 where R3 and R4 are not COOCH3 when R1 and R2 are hydrogen.