Patent ID: 6136967
Filing Date: 2000-10-24
Classification: C07D

Abstract:
A process for preparing a (Z)-isomer enriched 7-amino-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid in free acid or salt form by depleting 7-amino-3-{3(E)-1-propen-1-yl}-3-cephem-4-carboxylic acid in a mixture of 7-amino-3-{(Z)-1-propen-1-yl}-3-cephem-4-carboxylic acid and 7-amino-3-{(E)-1-propen-1-yl}-3-cephem-4-carboxylic acid which comprises subjecting a solution of a mixture of the (Z)- and (E)-isomers of the compound of the formula ##STR8## to adsorption chromatography.