Patent ID: 6667319
Filing Date: 2003-12-23
Classification: A61P,C07D

Abstract:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein:X is C; Z is independently NR8 or CR3R9; D is independently H, â€”OH, -alkyl or substituted -alkyl; E is independently H, -alkyl or substituted -alkyl, or D and E can independently be joined together via a â€”(CH2)pâ€” bridge; Q is independently H, -alkyl or substituted -alkyl; g, j, k, m and n can be the same or different and are independently selected; g is 0 to 3 and when g is 0, the carbons to which (CH2)g is shown connected are no more linked; j and k are independently 0 to 3 such that the sum of j and k is 0, 1, 2 or 3; m and n are independently 0 to 3 such that the sum of m and n is 1, 2,3, 4 or 5; p is 1 to 3; R1 is 1 to 5 substituents which can be the same or different, each R1 being independently selected from the group consisting of hydrogen, hydroxy, halogen, haloalkyl, -alkyl, substituted -alkyl, -cycloalkyl, CN, alkoxy, cycloalkoxy, alkylthio, cycloalkylthio, â€”NR5R6, â€”NO2, â€”CONR5R6, â€”NR5COR6, â€”NR5CONR5R6 where the two R5 moieties can be the same or different, â€”NR6C(O)OR7, â€”C(O)OR6, â€”SOR7, â€”SO2R7, â€”SO2NR5R6, aryl and heteroaryl; R2 is 1 to 6 substituents which can be the same or different, each R2 being independently selected from the group consisting of hydrogen, -alkyl, substituted -alkyl, alkoxy, and hydroxy; R3 is independently hydrogen, -alkyl or substituted -alkyl; R4 is 1 to 6 substituents which can be the same or different, each R4 being independently selected from hydrogen, -alkyl, substituted -alkyl, alkoxy, and hydroxy, with the proviso that when Z is NR8 and R4 is hydroxy or alkoxy, R4 is not directly attached to a carbon adjacent to the NR8; R5 and R6 are independently hydrogen, -alkyl, substituted -alkyl or -cycloalkyl; R7is independently -alkyl, substituted -alkyl or -cycloalkyl; R8 is independently selected from the group consisting of hydrogen, -alkyl, substituted -alkyl, -cycloalkyl, -alkylcycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, â€”SO2R10, â€”SO2NR5R11, â€”C(O)R11, â€”C(O)NR5R11 and â€”C(O)OR10; R9 is independently hydrogen, -alkyl, substituted -alkyl, hydroxy, alkoxy, â€”NR5R11, aryl, or heteroaryl; or R3 and R9 can be joined together and with the carbon to which they are attached form a carbocyclic or heterocyclic ring having 3 to 7 ring atoms; R10 is -alkyl, substituted -alkyl, -cycloalkyl, -alkylcycloalkyl, aryl or heteroaryl; and R11 is independently hydrogen, -alkyl, substituted -alkyl, -cycloalkyl, aryl or heteroaryl.