Patent ID: 7433788
Filing Date: 2008-10-07
Classification: A61P,C07K

Abstract:
1. A method of identifying an agonist or antagonist of insulin-like growth factor 1 (IGF-1) of SEQ ID NO: 1, comprising (i) obtaining a crystal formed by said IGF-1 of SEQ ID NO: 1 that diffracts x-ray radiation to produce a diffraction pattern representing the three-dimensional structure of the IGF-1 of SEQ ID NO: 1, including a receptor binding region comprising residues Tyr24, Thr29, Tyr31, and Tyr60 of said IGF-1 of SEQ ID NO: 1, and has approximately the following cell constants a=31.831 Å, b=71.055 Å, c=65.995 Å, and a space group of C222 1 , and α=β=γ, (ii) employing said three-dimensional structure to identify a compound that has a receptor-binding region that assumes the structure of or binds to said receptor binding region, and (iii) confirming that said compound acts as an IGF-1 agonist or antagonist thereby identifying said agonist or antagonist.