Patent ID: 8945566
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A method for treating cancer in a human patient comprising administering to the patient a therapeutic IgE antibody in combination with at least one immunostimulatory compound wherein the immunostimulatory compound is a TLR3 agonist or a TLR4 agonist; and at least one immunosuppressive agent wherein the immunosuppressive agent is a corticosteroid and optionally in further combination with a chemotherapeutic agent wherein the chemotherapeutic agent is gemcitabine, cyclophosphamide, topotecan, or doxorubicin, wherein the IgE antibody is a monoclonal antibody comprising human Fc epsilon (ε) constant regions and a variable region comprising at least one antigen binding region specific for a cancer antigen and wherein the immunosuppressive agent is administered to the patient at least 30 minutes prior to administration of the therapeutic IgE antibody.