Patent ID: 6100067
Filing Date: 2000-08-08
Classification: A61K,A61P,C07K,C12Q,Y02A,Y10S

Abstract:
A nucleotide sequence encoding a portion of a Plasmodium falciparum protein selected from the group consisting of(1) an amino acid sequence of between 10 and 87 consecutive amino acids of the following sequence:Glu-Phe-Arg-Val-Ser-Thr-Ser-Asp-Thr-Pro-Gly-Gly-Asn-Glu-Ser-Ser-Ser-Ala-Ser -Pro-Asn-Leu-Ser-Gly-Ala-Arg-Glu-Lys-Lys-Asp-Glu-Lys-Glu-Ala-Ser-Glu-Gln-Gl y-Glu-Glu-Ser-His-Lys-Lys-Glu-Asn-Ser-Gln-Glu-Ser-Ala-Asn-Gly-Lys-Asp-Asp-V al-Lys-Glu-Glu-Lys-Lys-Thr-Asn-Glu-Lys-Lys-Asp-Asp-Gly-Lys-Thr-Asp-Lys-Val- Gln-Glu-Lys-Val-Leu-Glu-Lys-Ser-Pro-Lys-Glu-Phe;(2) the 87 amino acids according to (1);(3) the amino acid sequence:Ala-Arg-Glu-Lys-Lys-Asp-Glu-Lys-Glu-Ala-Ser-Glu-Gln-Gly-Glu-Glu-Ser-His-Lys -Lys-Glu-Asn-Ser-Gln-Glu-Ser-Ala; and(4) the amino acid sequence:Asn-Gly-Lys-Asp-Asp-Val-Lys-Glu-Glu-Lys-Lys-Thr-Asn-Glu-Lys-Lys-Asp-Asp-Gly -Lys-Thr-Asp-Lys-Val-Gln-Glu Lys-Val-Leu-Glu-Lys-Ser-Pro-Lys-Glu-Phe,wherein said amino acid sequence is recognized by antibodies recognizing the sporozoite and hepatic stages of Plasmodium falciparum and is not recognized by antibodies recognizing the blood stage of Plasmodium falciparum.