Patent ID: 8036835
Filing Date: 2011-10-11
Classification: B01J,C12Q,G16B

Abstract:
1. A computer-implemented method for generating a set of probe nucleic acid sequences, the method comprising: (a) sorting a plurality of candidate probe nucleic acid sequences, for a genomic region of interest, from smallest genomic distance to largest genomic distance between neighboring candidate probe nucleic acid sequences to produce a sorted plurality of candidate probe nucleic acid sequences; (b) evaluating a probe parameter for a neighboring pair of candidate probe nucleic acid sequences from said sorted plurality to identify a first member of said neighboring pair with a more desirable probe parameter than a second pair member of said neighboring pair; (c) removing said second pair member from said plurality; (d) reiterating said sorting, evaluating and removing steps at least once to generate a set of probe nucleic acid sequences; and (e) outputting said set of probe nucleic acid sequences wherein said method is performed by a computer that is programmed to perform said method.