Patent ID: 8541545
Filing Date: 2013-09-24
Classification: A61K,A61P,C07K

Abstract:
1. A non-naturally occurring melanocortin ligand comprising a melanocortin analog coupled to a degradation-resistant C-terminal extension and an N-terminal extension, the non-naturally occurring melanocortin ligand comprising Formula I: wherein the melanocortin analog comprises R 1 to R 7 , wherein: R R R R R R R wherein if R wherein if R wherein the degradation-resistant C-terminal extension comprises X 1 to X 3 : X X X wherein when X wherein the N-terminal extension comprises Y 1 to Y 3 : Y Y Y wherein the melanocortin ligand is cyclized through a moiety selected from the group consisting of: a disulfide bond between R a lactam bridge between R a side-chain lactam bridge between R a lactam closure between R a lactam closure between R