Patent ID: 7893198
Filing Date: 2011-02-22
Classification: A61K,C07K,C12N,G01N,Y10T

Abstract:
1. A multilayer film, comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes, wherein a first layer polyelectrolyte comprises a composite polypeptide comprising one or more non-homopolymer surface adsorption regions covalently linked to one or more functional regions forming a single polypeptide chain, wherein the composite polypeptide and the one or more non-homopolymer surface adsorption regions have the same polarity, wherein the composite polypeptide is an unbranched polypeptide, is not a homopolymer, is at least 15 amino acid residues long, and has an aqueous solubility at pH 4 to 10 of greater than 50 μg/mL; wherein a second layer comprises a second layer polyelectrolyte comprising a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule, and a charge opposite that of the first layer polypeptide; and with the proviso that the one ore more functional regions is not an antimicrobial peptide, a cysteine-containing sequence or a sequence found in a human blood protein.