Patent ID: 6491965
Filing Date: 2002-12-10
Classification: A61K,A61L

Abstract:
A material for use in a medical or prosthetic device, said material comprising a polymer covalently attached to a covalent comjugate composition, said covalent conjugate composition comprising glycosaminoglycans linked to a species by covalent linkage, wherein the species comprises at least one primary amino group, and wherein the species is directly covalently linked via said amino group to a terminal aldose residue of the glycosaminoglycans, said covalent linkages comprising an &agr;-carbonyl amine formed by a substantial amount of subsequent Amadori rearrangement of an imine resulting from reaction between said amino group and said terminal aldose residue of said glycosaminoglycans,wherein said glycosaminoglycans are heparin (H) and said amino-containing species is antithrombin III (AT).