Patent ID: 7459459
Filing Date: 2008-12-02
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein X is carbon; Y is nitrogen; W is carbon or nitrogen; U and Z each independently, is CR R (i) hydrogen, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) halogen atom, (vi) CF (vii) cyano, (viii) nitro, (ix) NR (x) OR (xi) SH, (xii) S(O) (xiii) COR (xiv) COOR (xv) CONR (xvi) C3-10 mono-or bi-carbocyclic ring, (xvii) 3-10 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s) or (xviii) C1-4 alkyl substituted by 1-2 of substitutes selected from halogen atom, CF R (i) hydrogen, (ii) C1-4 alkyl, (iii) C2-4 alkenyl, (iv) C2-4 alkynyl, (v) C3-10 mono- or bi-carbocyclic ring, (vi) 3-10 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s) or (vii) C1-4 alkyl substituted by C3-10 mono- or bi-carbocyclic ring or 3-10 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s), is C4-6 carbocyclic ring which is unsubstituted or substituted by 1-3 of substitutes selected from C1-4 alkyl, C1-4 alkoxy, halogen atom and CF 3 , R (i) C1-8 alkyl which is unsubstituted or substituted by 1-5 of R (ii) C2-8 alkenyl which is unsubstituted or substituted by 1-5 of R (iii) C2-8 alkynyl which is unsubstituted or substituted by 1-5 of R (iv) NR (v) OR (vi) SH, (vii) S(O)nR (viii) COR (ix) COOR (x) CONR (xi) NR (xii) NR (xiii) NR (xiv) C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 of R (xv) 3-15 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s) which is unsubstituted or substituted by 1-5 of R R R R R R R R R (ii) 5-10 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s) substituted by 1-5 of R R (b) C2-8 alkenyl, (c) C2-8 alkynyl, (d) halogen atom, (e) CF (f) OCF (g) cyano, (h) nitro, (j) NR (k) OR (l) SH, (m) S(O) (n) COR (o) COOR (p) CONR (q) NR (r) NR (s) NR (t) C3-10 mono- or bi-carbocyclic ring, (u) 3-10 membered mono- or bi-heterocyclic ring containing 1-4 of nitrogen(s), 1-2 of oxygen(s) and/or 1-2 of sulfur(s) (v) C1-4 alkyl substituted by 1-2 of substitutes selected from halogen atom, CF with the proviso that (1) when each of X and W is carbon, each of Y and Z is nitrogen, U is CR a pharmaceutically acceptable salt thereof or a hydrate thereof.