Patent ID: 6051584
Filing Date: 2000-04-18
Classification: A61P,C07D

Abstract:
A compound of Formula (I) ##STR14## wherein: A.sub.1 and A.sub.2 independently from each other denote a group Z--(CH.sub.2).sub.k --(NR'"").sub.q ; whereinZ is 2-pyridinyl or pyridopyridinyl wherein the heterocycle is substituted or unsubstituted by one or two C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.4, oxo, oxime, O--C.sub.1-4 alkyloxime, hydroxy, N(R.sub.3).sub.2, acylamino or aminoacyl groups,R' and R"" are independently hydrogen, C.sub.1-4 alkylC(O)R.sub.4, C.sub.1-4 alkyl or R' and R"" are benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sub.3).sub.2 ;k is an integer from 0 to 4;R'"" denotes Hydrogen, C.sub.1-4 -alkyl or C.sub.1-4 -alkylcarboxylic acid;q is an integer from 0 to 1;Q denotes a group ##STR15## wherein: B.sub.1 denotes halogen, --(CH.sub.2).sub.m --CN, --(CH.sub.2).sub.m+1 --R.sup.2, --(CH.sub.2).sub.m --R.sup.3, --(CH.sub.2).sub.m --COR.sup.2 or --(CH.sub.2).sub.m --COR.sup.3 ; whereR.sup.2 denotes --OR.sup.3, --N(R.sup.3).sub.2, --SR.sup.3 ;R.sup.3 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;m is an integer from 0 to 4;C.sub.1 denotes halogen, --(CH.sub.2).sub.n --CN, --(CH.sub.2).sub.n+1 --R.sup.4, --(CH.sub.2).sub.n --R.sup.5, --(CH.sub.2).sub.n --COR.sup.4 or --(CH.sub.2).sub.n --COR.sup.5 ; whereR.sup.4 is independently --OR.sup.5, --N(R.sup.5).sub.2, --SR.sup.5 ;R.sup.5 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;n is independently an integer from 0 to 4;B.sub.2 denotes halogen, --(CH.sub.2).sub.k --CN, --(CH.sub.2).sub.k+1 --R.sup.6, --(CH.sub.2).sub.k --R.sup.7, --(CH.sub.2).sub.k --COR.sup.6 or --(CH.sub.2).sub.k --COR.sup.7 ; whereR.sup.6 is independently --OR.sup.7, --N(R.sup.7).sub.2, --SR.sup.7 ;R.sup.7 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;k is an integer from 0 to 4;C.sub.2 denotes halogen, --(CH.sub.2).sub.l --CN, --(CH.sub.2).sub.l+1 --R.sup.8, --(CH.sub.2).sub.l --R.sup.9, --(CH.sub.2).sub.l --COR.sup.8 or --(CH.sub.2).sub.l --COR.sup.9 ; whereR.sup.8 is independently --OR.sup.9, --N(R.sup.9).sub.2, --SR.sup.9 ;R.sup.9 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;1is an integer from 0 to 4;D denotes --(CH.sub.2).sub.x --E--(CH.sub.2).sub.y --; whereinE denotes a single bond or --C.dbd.C--, --C.tbd.C--, or --NH--, --O--, ##STR16## --S-- or --S--S--; and x and y independently denote an integer from 0 to 5, with the proviso thatx and y are not 0 if E denotes --NH, --O--, --S--or --S--S--; with the proviso that B.sub.1 is not identical to C.sub.1 and B.sub.2 is not identical to C.sub.2 ;B.sub.1 .noteq.B.sub.2 ; andC.sub.1 .noteq.C.sub.2 ;and pharmaceutically acceptable salts thereof.