Patent ID: 8021672
Filing Date: 2011-09-20
Classification: A61K,C12N,C12R

Abstract:
1. An isolated plasmid-deficient Chlamydia sp. strain wherein the strain causes reduced pathology as compared to a corresponding plasmid-containing disease-causing Chlamydia strain in a vertebrate; and wherein following inoculation with the plasmid-deficient Chlamydia strain, when a vertebrate is infected with the corresponding plasmid-containing disease-causing strain the vertebrate experiences reduced pathology as compared to a vertebrate not previously inoculated with the plasmid-deficient Chlamydia strain; wherein the strain is prepared by a process comprising: treating the plasmid-containing disease-causing incubating host cells with the treated culturing the verifying that wherein the strain does not stimulate TLR2-dependent IL-8 secretion.