Patent ID: 6063794
Filing Date: 2000-05-16
Classification: A61K,C07D,C07F,C07K

Abstract:
A compound having the formula: ##STR44## wherein R.sup.2 is H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-3 alkylaryl, C.sub.1-3 alkyl-C.sub.3-8 cycloalkyl or aryl;R.sup.3 is H, C.sub.1-6 alkyl, or R.sup.2 and R.sup.3 are taken together to form a carbocyclic ring;R.sup.13 is H, C.sub.1-3 alkyl, C.sub.1-3 alkylaryl, aryl, or --CF.sub.3 ;R.sup.1 is H, C.sub.1-3 alkyl, C.sub.1-3 alkylaryl, aryl, or --CF.sub.3 ;R.sup.14 is H, C.sub.1-3 alkyl, C.sub.1-3 alkylaryl, aryl, or --CF.sub.3 ;m is an integer from 0-3;n is an integer from 0-6;p is an integer from 0-4;s is an integer from 0-2;W is C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.1-6 alkenyl, or aryl;K is selected from the group consisting of a direct link, C.sub.3-8 cycloalkyl, aryl;E is selected from the group consisting of R.sup.26, --NR.sup.26 R.sup.27, ##STR45## R.sup.26, R.sup.27, R.sup.28 and R.sup.29 are independently selected from the group consisting of H, --OH,C.sub.1-6 alkyl, aryl and C.sub.1-4 alkylaryl;R.sup.30 is selected from the group consisting of H, C.sub.1-6 alkyl, aryl and C.sub.1-4 alkylaryl; andR.sup.31 is selected from the group consisting of H, C.sub.1-6 alkyl, aryl and C.sub.1-4 alkylaryl, or all optical isomers thereof.