Patent ID: 7989446
Filing Date: 2011-08-02
Classification: A61P,C07D

Abstract:
1. A 4-amino-5-cyanopyrimidine compound of the formula (1): or a pharmaceutically acceptable salt thereof, wherein R R R wherein R Z the amino group of the above (c3) and the amino moiety included as a part of the groups in the above (c4), (c6), and (c11) may be optionally substituted with 1 or 2 substituents selected from the group consisting of a lower alkyl group, a hydroxy-lower alkyl group, a phenyl group, and a lower alkoxycarbonyl group; the amino moiety included as a part of the groups in the above (c11) may be optionally substituted with an aryl-lower alkylcarbonyl group; the piperazino group of the above (c5) and 1,4-diazepan-1-yl group of the above (c8) may be substituted with any one of the substituents selected from the group consisting of a lower alkyl group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a phenyl group, a lower alkylphenyl group, a hydroxyphenyl group, a cyanophenyl group, a halogenophenyl group, a phenyl-lower alkyl group, a lower alkoxyphenyl-lower alkyl group, a halogenophenoxy-lower alkyl group, a pyridyl group, a lower alkylpyridyl group, a halogeno-lower alkylpyridyl group, a cyanopyridyl group, a pyridyl-lower alkyl group, a lower alkoxycarbonyl group and a lower alkylcarbonyl group on 4-position of the ring system; further the saturated heterocycle moiety included as a part of the groups in the above (c18), (c21) and (c22) may be a monovalent saturated heterocycle group selected from the group consisting of pyrrolidinyl, pyrrolidino, piperidyl, piperidino, piperazinyl, piperazino, 1,4-diazepan-1-yl, tetrahydrofuryl, 1,3-dioxolanyl, tetrahydrothienyl, morpholinyl, morpholino and tetrahydroimidazolyl, optionally having any one of the substituents selected from the group consisting of a lower alkyl group, a phenyl group, a cyanophenyl group, a lower alkylcarbonyl group, a halogeno-lower alkylphenyl group and a phenyl-lower alkyl group on the nitrogen atom of the ring system; and furthermore the piperazino group of the above (c5), the piperidino group of the above (c10) and the saturated heterocycle moiety included as a part of the groups in the above (c18), a lower alkylpiperazino group having a saturated heterocycle and (c22) a lower alkylmorpholino group having a saturated heterocycle may be substituted with any one of the substituents selected from the group consisting of a hydroxy group, an oxo group, a lower alkyl group, a hydroxy-lower alkyl group, a phenyl group, a phenyl-lower alkyl group, an aminocarbonyl group and a lower alkylamino group on the carbon atom of the ring system.