Patent ID: 6972343
Filing Date: 2005-12-06
Classification: A61K,A61P,C07C,C07D

Abstract:
1. Precursors of drugs with an anti-malarial action, characterized in that they are precursors of quaternary bis-ammonium salts and that they correspond to general formula (I) in which A and A′ are identical to or different from one another and represent either, an A where n is an integer from 2 to 4; R′ or an A B and B′ are identical to or different from one another and represent either the B or the B  in which —Ra represents an RS— or RCO— group, where R is a linear, branched or cyclic C1 to C6 alkyl radical, optionally substituted by one or more hydroxy, alkoxy or aryloxy group, or an amino group and/or a —COOH or COOM group, where M is a C1 to C3 alkyl; a phenyl or benzyl radical, in which the phenyl radical is optionally substituted by at least one C1 to C5 alkyl or alkoxy radical, these being optionally substituted by an amino group, or by a nitrogenous or oxygenous heterocycle, a —COOH or —COOM group; or a saturated —CH α represents either a single bond, when A and A′ represent A  or, when A and A′ represent A  or a group of formula  in which (a) represents a bond towards Z and (b) a bond towards the nitrogen atom, Z represents a C6 to C21 alkylene radical, optionally with insertion of one or more multiple bonds, and/or one or more O and/or S heteroatoms, and/or one or more aromatic rings, and the pharmaceutically acceptable salts of these compounds, provided that R′