Patent ID: 6121433
Filing Date: 2000-09-19
Classification: A61K,C07D,C07F,C07H,C08G,C12N,C12Q,C12Y

Abstract:
A compound having the structure: ##STR5## wherein: each Z is, independently, H, a nitrogen protecting group, --T--L, N(--T--L).sub.2, a reporter molecule, or an RNA cleaving group;zz is from 1 to about 90;each k is, independently, 0 or 1;at least one Q is O, and each remaining Q is independently O or (CH.sub.2).sub.m ;each A is, independently, N--T--L, C(O), a single bond, or (CH.sub.2).sub.m ;each m is, independently, from 1 to 5;each T is, independently, a single bond or a group having structure II:--[CR.sup.1 R.sup.2 ].sub.n --B--[CR.sup.1 R.sup.2 ].sub.o --[D].sub.p --[N(R.sup.3)].sub.q -- IIwhere:D is C(O), C(S), C(R.sup.1)(NR.sup.3 R.sup.4), CR.sup.1 R.sup.2, or NR.sup.3 ;B is a single bond, CH.dbd.CH, C.tbd.C, O, S or NR.sup.4 ;each R.sup.1 and R.sup.2 is, independently, selected from the group consisting of hydrogen, alkyl having 1 to about 12 carbon atoms, alkenyl having 1 to about 12 carbon atoms, hydroxy-, alkoxy- or alkylthio-substituted alkyl having 1 to about 12 carbon atoms, hydroxy-, alkoxy- or alkylthio-substituted alkenyl having 1 to about 12 carbon atoms, hydroxy, alkoxy, alkylthio, arnino and halogen;each R.sup.3 and R.sup.4 are, independently, H, alkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, alkynyl having 2 to about 10 carbon atoms, aryl having 7 to about 14 carbon atoms, heterocyclic; orR.sup.3 and R.sup.4, together, are cycloalkyl having 3 to about 10 carbon atoms or cycloalkenyl having 4 to about 10 carbon atoms;n and o are, independently, 0 to 5;q and p are, independently 0 or 1;each L is, independently, H, substituted or unsubstituted C.sub.2 -C.sub.10 alkyl, substituted or unsubstituted C.sub.2 -C.sub.10 alkenyl, substituted or unsubstituted C.sub.2 -C.sub.10 alkynyl, substituted or unsubstituted C.sub.4 -C.sub.7 carbocylo alkyl, substituted or unsubstituted C.sub.4 -C.sub.7 carbocylo alkenyl, substituted or unsubstituted C.sub.7 -C.sub.14 aralkyl, a heterocyclic moiety having heteroatoms selected from nitrogen, oxygen and sulfur, where said substitutions are selected from alkyl, alkenyl, alkynyl, alkoxy, thiol, thioalkoxy, hydroxyl, aryl, benzyl, phenyl, nitro, and halogen, an ether having 2 to 10 carbon atoms and 1 to 4 oxygen or sulfur atoms, a polyalkyl glycol, a metal coordination group, a conjugate group, halogen, hydroxyl, thiol, keto, carboxyl, amide, ethers, thioethers, arnidine (C(.dbd.NH)NR.sup.3 R.sup.4), guanidine (NHC(.dbd.NH)NR.sup.3 R.sup.4), glutamyl CH(NR.sup.3 R.sup.4)(C(.dbd.O)OR.sup.3), nitrate (ONO.sub.2), nitro (NO.sub.2), nitrile, trifluoromethyl (--CF.sub.3), trifluoromethoxy (--OCF.sub.3), O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aralkyl, S-aralkyl, NH-aralkyl, amino, azido (N.sub.3), hydrazino (NHNH.sub.2), hydroxylamino (ONH.sub.2), sulfoxide (SO), sulfone (SO.sub.2), sulfide (S--), disulfide (S--S), silyl, a nucleosidic base, an amino acid side chain, a nitrogen protecting group, a carbohydrate, a drug, or a group capable of hydrogen bonding, provided that when each T is a single bond at least one L is not H or alkyl.