Patent ID: 6531450
Filing Date: 2003-03-11
Classification: A61K,A61P,C07K

Abstract:
A method for increasing survival of dopaminergic neurons in a human patient with an acute or a chronic neurological disease, comprising administering an amount of MP52 effective to increase the survival of dopaminergic neurons to said patient, wherein said MP52 is selected from the group consisting ofa) an amino acid sequence comprising residues 1 to 501 of SEQ ID NO: 1; b) an amino acid sequence encoded by nucleotide residues 640 to 2142 of SEQ ID NO: 2; c) an amino acid sequence comprising residues starting from 361 to 400 through 501 of SEQ ID NO: 1; d) an amino acid sequence comprising amino acid residues 382 to 501 of SEQ ID NO: 1; and/or e) an amino acid sequence according to (c), wherein the N-terminus is modified by addition of a methionine residue and/or a histidine tag.