Patent ID: 6645973
Filing Date: 2003-11-11
Classification: A61P,C07D

Abstract:
A spiro[2H-1-benzopyran-2,4â€²-piperidine] derivative having the formula I whereinthe dotted line represents an optional bond; Y represents 1-4 substituents independently selected from hydrogen, halogen, (C1-6)alkyl (optionally substituted with one or more halogens), (C1-6)alkyloxy (optionally substitued with one or more halogens or with (C3-6)cycloalkyl), (C2-6)alkenyloxy, (C2-6)alkynyloxy (C3-6)cycloalkyloxy, (C6-12)aryloxy, arylalkyloxy, SR3, NR3R4, OSO2R5 and NR3SO2R4; or Y represents a fused (C5-6)aryl group; X represents 1-3 substituents independently selected from hydrogen, halogen, hydroxy, (C1-4)alkyloxy, SR3, NR3SO2R4 and (C1-4)alkyl, optionally substituted with halogen; R1 is hydrogen, (C1-4)alkyl or (C6-12)aryl; R2, R3 and R4 are independently hydrogen or (C1-4)alkyl; R5 is (C1-4)alkyl (optionally substituted with one or more halogens) or (C6-12)aryl (optionally substituted with (C1-4)alkyl); or a pharmaceutically acceptable salt thereof.