Patent ID: 8580301
Filing Date: 2013-11-12
Classification: A61K,A61P

Abstract:
1. A method for the manufacture of a pharmaceutical composition comprising two distinct components, the first component containing an initial dosage of a psychostimulant and the second component containing a second dosage of said psychostimulant, wherein said psychostimulant is methylphenidate, and wherein the release of said second dosage is modified, characterized in that the release of said second dosage is modified by a single layer coating, wherein the single layer coating is an enteric coating comprising (co-)polymers of (meth)acrylic acid and/or (meth)acrylate containing carboxyl groups, thereby causing a sustained release of said second dosage of the psychostimulant in vivo, and wherein the in vivo release of the pharmaceutical composition is characterized by one single main plasma peak, comprising the steps of: a) manufacturing the first component by: b) manufacturing the second component by: