Patent ID: 6190894
Filing Date: 2001-02-20
Classification: A61K,Y10S

Abstract:
A method for disrupting the epithelial barrier function in a host in need of the topical administration of a physiologically active substance, which comprises applying to the epithelium of the host, a barrier-disrupting amount of at least one agent selected from the group consisting of inhibitors of ceramide synthesis, of glucosylceramide synthesis, of acylceramide synthesis, of sphingomyelin synthesis, of fatty acid synthesis, and of cholesterol synthesis; inhibitors of phospholipid, of glycosphingolipid, and of acylceramide degradation; degradation enzymes of free fatty acid, ceramide, sphingomyelin, acylceramide, and glucosylceramide; and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol.