Patent ID: 8623924
Filing Date: 2014-01-07
Classification: A23L,A23V,A61K,A61P

Abstract:
1. A composition comprising: (a) leucine and/or one or more leucine metabolites selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and hydroxymethylbutyrate (HMB); and (b) a sirtuin-pathway activator; wherein molar ratio of component (a) to (b) in said composition is greater than about 20, and wherein the composition when administered to a subject in need thereof synergistically enhances mitochondrial biogenesis as measured by a decrease in weight gain of a subject, a decrease in visceral adipose volume of a subject, an increase in fat oxidation of a subject, an increase in irisin production of a subject, an increase in insulin sensitivity of a subject, an increase of glucose uptake in muscle of a subject, a decrease in inflammation markers, an increase in vasodilatation, and/or an increase in body temperature; wherein the composition is substantially free of non-branched amino acids; and wherein the composition comprises at least about 500 mg of leucine and/or at least about 200 mg of the one or more leucine metabolites.