Patent ID: 8841253
Filing Date: 2014-09-23
Classification: A61K,C07K,G01N

Abstract:
1. An isolated cytosolic translocation factor (CTF) complex-binding polypeptide comprising a toxin transmembrane helix domain comprising the sequence of SEQ ID NO: 7, wherein said polypeptide further comprises one to ten motifs having the sequence of SEQ ID NO: 5 at the carboxy terminal end of the toxin transmembrane helix domain but does not comprise a motif having the sequence of SEQ ID NO: 5 at the amino terminus of said toxin transmembrane helix domain, and wherein said polypeptide binds one or more CTF complex components selected from α-coatomer protein (COP), β-COP, β′-COP, γ-COP, δ-COP, ε-COP, ζ-COP, heat shock protein-90 (HSP-90), and thioredoxin reductase-1 (TrR-1).