Patent ID: 6329418
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A compound having the following structure: ##STR38##wherein(a) R.sub.1 is NR.sub.3 OR.sub.3, wherein each R.sub.3 is independently selected from the group consisting of hydrogen, lower alkyl, and acyl;(b) X is SO.sub.2 or CO;(c) R.sub.2 is selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, and heteroaryloxy;(d) Z is selected from the group consisting of:(i) N--W, wherein n is at least 1 and W is selected from the group consisting of: aryl, heteroaryl, cycloalkyl, and hetcrocycloalkyl;(ii) N--OP.sub.4, N--SR.sub.4, N--NR.sub.4 R.sub.4, or N--CR.sub.4 R.sub.4 R.sub.4, wherein n is at least 1 and each R.sub.4 is independently selected from the group consisting of:hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; ##STR39##wherein 11 is at least 1 and each Q is independently selected from the group consisting of S and O; ##STR40##wherein n is at least 1;(v) CR.sub.6 R.sub.6, wherein each R.sub.6 is independently selected from the group consisting of: hydrogen, halo, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, and cyano;(vi) a ring, said ring being selected from the group consisting of: cycloalkyl and heterocyloalkyl; ##STR41##(e) m and n are integers independently selected from 0, 1, or 2 and m+n is 2; andany optical isomer, diastcreomer or enantiomer, or pharmaceutically-acceptable salt, solvate thereof.