Patent ID: 6479528
Filing Date: 2002-11-12
Classification: A61K,A61P

Abstract:
A method for regulating the assembly of the protein tau in the brain of a patient, comprises:identifying a patient in need of a method for inhibiting tau polymerization in the brain; and administering to the patient a pharmacologically effective amount of an inhibitor of fatty acid oxidation, wherein the inhibitor is selected from the group consisting of (1) a first compound of the general formula I â€ƒwherein R1 is an aliphatic radical having one to six carbon atoms and wherein R2 and R3 independently are a second aliphatic radical having one to six carbon atoms, a hydroxyl-substituted aliphatic radical having one to six carbon atoms, or a pheny radical; (2) a second compound of general formula II â€ƒwherein R4, R6, and R8 are independently a third aliphatic radical having 1 to 6 carbon atoms and R5 and R7 are independently a fourth aliphatic radical having 1 to 6 carbon atoms or a second hydroxyl-substituted aliphatic radical having one to six carbon atoms; (3) a third compound of general formula III â€ƒ(4) a fourth compound of general formula IV â€ƒwherein R9 and R10 independently are a fourth aliphatic radical having 1 to 6 carbon atoms; (5) a fifth compound of general formula V â€ƒwherein R11 is a carboxylic acid-substituted aliphatic radical having 1 to 6 carbon atoms and R12 is a fifth aliphatic radical having 1 to 6 carbon atoms; and (6) pharmaceutically acceptable salts thereof.