Patent ID: 6784210
Filing Date: 2004-08-31
Classification: A61P,C07B,C07C,C07D,C07F

Abstract:
A compound according to formula IV: wherein: a) R8 is H or CH3; b) t=0-3 c) R9 is a C3-C6 aryl optionally substituted at one or more positions with a group selected from: a C1-C3 alkyl; a C1-C3 alkoxy; Cl; F; NO2; and CF3; d) X and Y are independently selected from the group consisting of H; NH2; F; Cl; Br; a C1-C3 alkyl; and a C1-C3 alkoxy; or wherein the combination XY or YY together form a C3-C6 carbocyclic ring or a C3-C6 heterocyclic ring containing one or more heteroatoms selected from the group consisting of O; N; and S; e) Z is selected from O or NRa, wherein Ra is selected from: (i) a straight or branched C1-C6 alkyl; (ii) phenyl; (iii) (O)Câ€”Oâ€”Rb, wherein Rb is a straight or branched C1-C6 alkyl; (iv) â€”SO2â€”Rc, wherein Rc is an unsubstituted phenyl or a phenyl substituted with a C1-C3 alkyl or NO2; and (v) â€”SO2â€”(CH2)qâ€”Si(CH3)3 wherein q is 1-3; and with the proviso that when Z is O, R10 is H; when Z is NRa, R10 is either H or CH3; and with the further proviso that when Z is O and R10 is H, t is 2 or 3 and either X or Y is not H.