Patent ID: 7425606
Filing Date: 2008-09-16
Classification: A61P,C07K,C12N,G01N

Abstract:
1. An immunogenic peptide epitope which is derived from a subdominant/cryptic epitope presented by HLA A2.1 by substitution of the N-terminal amino acid of said subdominant/cryptic epitope with a tyrosine residue, wherein said subdominant/cryptic epitope is chosen from: the peptide HER-2/neu 650: PLTSIISAV (SEQ ID No. 4) the peptide HER-2/neu 466: ALIHITNTHL (SEQ ID No. 5) the peptide HER-2/neu 402: TLEEITGYL (SEQ ID No. 6) the peptide HER-2/neu 391: PLQPEQLQV (SEQ ID No. 7) the peptide gagp24-212: EMMTACQGV (SEQ ID No. 8) the peptide pol79: LLDTGADDTV (SEQ ID No. 9) the peptide mhp 572: RLFFYRKSV (SEQ ID No. 10) the peptide mhp 988: DLQVNSLQTV (SEQ ID No. 11).