Patent ID: 8222203
Filing Date: 2012-07-17
Classification: A61K,A61P,C07K

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein A is absent or selected from the group consisting of —(C═O)—, —S(O) R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C J is selected from the group consisting of —C(R R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C B is: (i) C (ii) substituted C (iii) C (iv) C Y is absent or selected from O, S, NR X a) hydrogen for X b) aryl; c) substituted aryl; d) heteroaryl; e) substituted heteroaryl; f) heterocyclic or substituted heterocyclic; g) C h) substituted C i) C j) C k) W—R or X 1 and X 2 taken together with the carbon atom to which they are attached form a cyclic moiety selected from: substituted or unsubstituted cycloalkyl, cycloalkenyl, or heterocylic; substituted or unsubstituted cycloalkyl, cycloalkenyl, and heterocylic fused with one or more aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, substituted cycloalkyl, cycloalkenyl, or substituted cycloalkenyl; L is selected from the group consisting of: (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C Z is selected from the group consisting of: (i) hydrogen; (ii) SR (iii) OR (iv) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (v) heterocycloalkyl or substituted heterocycloalkyl; and (vi) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C G is selected from the group consisting of —NHS(O) R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C m=0, 1, or 2; n=1, 2 or 3; and k=1, 2 or 3.