Patent ID: 6441131
Filing Date: 2002-08-27
Classification: C07K,C12N,Y02P

Abstract:
A peptide of the formula (I) wherein,Q is Qaâ€”(AA)nâ€”, wherein AA is L-amino acid, n is 0 or an integer of 1-15, Qa is hydrogen, C1-4 alkyl, an amino-protective group, D- or L-amino acid residue or NH2â€”(CH2)râ€”COâ€”, where r is an integer of 2-7, R1 and R2 are (i) hydrogen or halogen or, (ii) R1, R2 and an unsaturated bond together form an aromatic carbon ring that may be substituted by halogen, R3 is hydrogen or halogen, R4 is hydrogen, C1-3 alkyl or hydroxymethyl, EE is D- or L-amino acid, m is 0 or 1, and Z is an aniline derivative residue, an aminocoumarine derivative residue or an aminonaphthalene derivative residue, with the proviso that (I) when n is 2 or more, each AA is same or different, and that (2) the compounds wherein all of R1, R2 and R3 are hydrogen are excluded, or an acid addition salt thereof.