Patent ID: 7081133
Filing Date: 2006-07-25
Classification: A61F,A61L

Abstract:
1. A method of providing resistance to pannus overgrowth to an implantable prosthetic heart valve comprising: A) providing an implantable heart valve comprising a valve orifice defining a blood flow area, a leaflet coupled to said orifice for movement between an open position and a closed position, and a sewing cuff coupled to said orifice, said sewing cuff comprising a material suitable for retaining an antibiotic; B) providing an antibiotic solution comprising minocycline and rifampin dissolved in a solvent, wherein said solvent comprises SCO2; C) contacting said material suitable for retaining an antibiotic and said antibiotic solution to obtain an antimicrobial reservoir; D) removing the solvent from said antimicrobial reservoir; and E) implanting said heart valve.