Patent ID: 8697858
Filing Date: 2014-04-15
Classification: A61K,A61P,C07F,C07K,C12N

Abstract:
1. An isolated antiviral antisense oligonucleotide, comprising a) a nuclease-resistant backbone; b) 12-40 nucleotide bases, and c) a targeting sequence of at least 10 bases in length that hybridizes to a target region selected from the 45 bases surrounding the AUG start codon of an influenza viral M1 or M2 mRNA; wherein the oligonucleotide (i) comprises morpholino subunits linked by substantially uncharged, phosphorous-containing intersubunit linkages that join a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit; (ii) comprises one or more locked nucleic acid subunits; (iii) comprises 2′OMe residues; or (iv) is a peptide nucleic acid; wherein the oligonucleotide comprises a base sequence selected from the group consisting of: SEQ ID NOS:12-16, 19-22, 34 and 45-47.