Patent ID: 7354736
Filing Date: 2008-04-08
Classification: A01K,A61P,C07K

Abstract:
1. An isolated polypeptide capable of binding to pro-caspase-8 selected from the group consisting of: a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 3 (Cari); b) a variant of Cari (SEQ ID NO: 3) comprising no more than ten amino acid changes and retains the capability of binding to pro-caspase-8; c) a fragment of Cari (SEQ ID NO: 3) having the sequence of SEQ ID NO: 5 and includes the pro-caspase-8 binding site; and d) a derivative of Cari (SEQ ID NO: 3), which is prepared by modifying the —NH without the proviso that said polypeptide is not DF518-3.