Patent ID: 7745144
Filing Date: 2010-06-29
Classification: A61K,A61P,C07K

Abstract:
1. A peptide comprising the sequence R 1 —X 1 —X 2 —X 3 —X 4 —R 2 — or full retro-inverso sequences thereof, wherein X 1 is selected from the group consisting of N, Q, D and S; X 2 is V; X 3 is R; and X 4 is selected from the group consisting of L and F; R 1 is a peptide comprising the sequence selected from FQGVLQ (SEQ ID NO:13), FAGVLQ (SEQ ID NO:14), FQGVAQ (SEQ ID NO:15), FQGVLA (SEQ ID NO:16), and FQGVLN (SEQ ID NO:17); and R 2 is from 1 to 3 amino acids, a hydroxide or an amide, wherein the peptide is up to 12 amino acids in length and binds to α3β1 integrin, and provided that the peptide does not comprise the sequence FQGVLQNVRFVF (SEQ ID NO:6) or DVRF (SEQ ID NO:54).