Patent ID: 6620826
Filing Date: 2003-09-16
Classification: C07D

Abstract:
A compound of Formula (I): wherein:R1 is H or C1-3alkoxy; R2 is â€”(CH2)xC(O)NHS(O)2R9, â€”OR5, â€”O(CH2)1-3CO2H or â€”(CH2)nR7; R3 is C1-5alkyl; R4 is hydrogen; R5 is â€”(CH2)xC(O)NHS(O)2R9, â€”(CH2)xC(O))NHC(O)R9, â€”(CH2)nR7 or pyridyl which may be unsubstituted or substituted by Z1;R6 is a moiety of formula (b), P is CO2H; R7 is hydroxy, â€”NHSO2R9, â€”CONH(C1-5alkyl), or R7 is tetrazol-5-yl or piperazinyl, both of which may be unsubstituted or substituted by C1-6alkyl, or R7 is thienyl, pyridyl, pyrimidyl, or phenyl, all of which may be unsubstituted or substituted by one or more Z1 or Z2 groups; R9 is C1-5alkyl, N(C1-5alkyl)2 or R9 is phenyl which may be unsubstituted or substituted by C1-5alkyl; n is 1 to 4; m is 1; x is 0 to 4; Z1 and Z2 are independently hydrogen, hydroxy, C1-6alkoxy, CO2H, C(O)NH2, F, Cl, or tetrazolyl which may be unsubstituted or substituted by C1-6alkyl; A is â€”CH2â€”; and B is â€”Oâ€”; and the dotted line indicates the presence of a double bond; or a pharmaceutically acceptable salt thereof.