Patent ID: 9175292
Filing Date: 2015-11-03
Classification: A61P,C12N

Abstract:
1. An aptamer of 73 nucleotides or fewer, comprising any one of the nucleotide sequences (a), (b) or (c) below: (a) a nucleotide sequence shown by SEQ ID NO: 26, wherein uracil may be thymine; (b) a nucleotide sequence shown by SEQ ID NO: 26, wherein uracil may be thymine, wherein 1 to 4 nucleotides other than in the sequence UGAAAGAAACC (SEQ ID NO: 67) are substituted, deleted, inserted or added; (c) a nucleotide sequence having an identity of 90% or more to the nucleotide sequence of SEQ ID NO: 26, wherein uracil may be thymine, that comprises the sequence UGAAAGAAACC (SEQ ID NO: 67); wherein the aptamer binds to Nerve Growth Factor (NGF) and inhibits the following (i) and/or (ii): (i) binding of NGF to an NGF receptor; (ii) neurite outgrowth activity or cell proliferation activity of NGF.