Patent ID: 6090836
Filing Date: 2000-07-18
Classification: A61K,C07D

Abstract:
A compound having the formula I: ##STR87## or a pharmaceutically acceptable salt thereof, wherein: R is selected from the group consisting of H, C.sub.1-6 alkyl, C.sub.5-10 aryl, and benzisoxazolyl, said alkyl, aryl and benzisoxazolyl optionally substituted with 1 to 3 groups of R.sup.a ;R.sup.1 is selected from a group consisting of: H, C.sub.1-15 alkyl, C.sub.2-15 alkenyl, C.sub.2-15 alkynyl and C.sub.3-10 cycloalkyl, said alkyl, alkenyl, alkynyl, and cycloalkyl optionally substituted with 1 to 3 groups of R.sup.a ;R.sup.3 is selected from a group consisting of: H, NHR.sup.1, NHacyl, C.sub.1-15 alkyl, C.sub.3-10 cycloalkyl, C.sub.2-15 alkenyl, C.sub.1-15 alkoxy, CO.sub.2 alkyl, OH, C.sub.2-15 alkynyl, C.sub.5-10 aryl, and benzisoxazolyl, said alkyl, cycloalkyl, alkenyl, alkynyl, aryl and benzisoxazolyl optionally substituted with 1 to 3 groups of R.sup.a ; ##STR88## R.sup.8 is selected from the group consisting of CR.sup.6 R.sup.7, O, NR.sup.6, and S(O).sub.p ;R.sup.6 and R.sup.7 are independently selected from the group consisting of H and C.sub.1-6 alkyl;B is an isoxazole, optionally unsubstituted or substituted with 1 group of R.sup.a ;X.sup.1 and X.sup.2 are independently selected from a group consisting of: H, OH, C.sub.1-15 alkyl, C.sub.2-15 alkenyl, C.sub.2-15 alkynyl, halo, OR.sup.3, ORCF.sub.3, C.sub.5-10 aryl, C.sub.5-10 aralkyl, benzisoxazolyl and C.sub.1-10 acyl, said alkyl, alkenyl, alkynyl, aryl and benzisoxazolyl optionally substituted with 1 to 3 groups of R.sup.a ;R.sup.a represents a member selected from the group consisting of: halo, acyl, aryl, benzisoxazolyl, CF.sub.3, OCF.sub.3, CN, NO.sub.2, R.sup.3, OR.sup.3 ; SR.sup.3, S(O)R.sup.3, .dbd.N(OR), SO.sub.2 R.sup.3, NR.sup.3 R.sup.3, NR.sup.3 COR.sup.3, NR.sup.3 CO.sub.2 R.sup.3, NR.sup.3 CON(R.sup.3).sub.2, NR.sup.3 SO.sub.2 R.sup.3, COR.sup.3, CO.sub.2 R.sup.3, CON(R.sup.3).sub.2, SO.sub.2 N(R.sup.3).sub.2, and OCON(R.sup.3).sub.2, said aryl and benzisoxazolyl optionally substituted with 1 to 3 groups of halo or C1-6 alkyl;Y is selected from the group consisting of: S(O).sub.p, --CH.sub.2 --, --C(O)--, --C(O)NH--, --NR--, --O--, --SO.sub.2 NH, and --NHSO.sub.2 ;Y.sup.1 is O;Z is selected from the group consisting of: CO.sub.2 R.sup.3, CONHSO.sub.2 R, CONH.sub.2 and 5-(1H-tetrazole);t and v are independently 0 or 1 such that t+v=1;Q is a saturated or unsaturated straight chain hydrocarbon containing 2-4 carbon atoms andp is 0-2.