Patent ID: 6372443
Filing Date: 2002-04-16
Classification: A61K,C07K,Y10S

Abstract:
A reagent for the detection or monitoring of a Toxoplasma gondii infection, which comprises, as reactive substance, a truncated Toxoplasma gondii P30 protein secreted by a non-mammalian eukaryotic cell transformed with an expression cassette comprising a DNA fragment encoding said truncated protein, in which:at least all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid +299 of the sequence SEQ ID No:1 has been deleted; and at least all the region of the native protein having the sequence starting with the amino acid +31 and ending with the amino acid +299 of the sequence SEQ ID No: 1 is contained, wherein said DNA fragment encoding the truncated Toxoplasma gondii P30 protein is placed under the control of elements necessary for said truncated Toxoplasma gondii P30 protein expression.