Patent ID: 9089543
Filing Date: 2015-07-28
Classification: A61K,A61P

Abstract:
1. A method of inhibiting formation of a mediator selected from the group consisting of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), or inhibiting activity of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) in a subject comprising: administering an effective amount of a composition comprising an active agent selected from the group consisting of macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A to a subject in need thereof, whereby the formation of a mediator selected from the group consisting of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), or the activity of iNOS and COX-2 in the subject is inhibited, wherein the subject does not have bacterial infection.