Patent ID: 8858987
Filing Date: 2014-10-14
Classification: A61L

Abstract:
1. A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the wound dressing material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the wound healing therapeutic agent and the inhibitor of the protease enzyme are each separately conjugated to the medically acceptable polymer by the linker group, wherein the linker group comprises an oligopeptidic sequence which is a substrate for the protease enzyme, wherein the therapeutic agent is a reactive oxygen scavenger, a pain relieving agent, an antiseptic, an analgesic, or a local anaesthetic, and further wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a wound fluid containing the protease enzyme; wherein the inhibitor of the protease enzyme is selected from the group consisting of Tissue Inhibitor of Metalloproteinase (TIMP), 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSE), antithrombin, (p-Amidinophenyl)methanesulfonyl fluoride (APMSF), Aprotinin, diisopropylfluorophosphate (DFP), phenyl methyl sulfonyl fluoride (PMSF), Antipain, Chymostatin, Leupeptin, Tosyl-lysine chlorormethylketone (TLCK), Tosyl-phenyl chloromethylketone (TPCK), L-transepoxysuccinylleucylamido (4-guanidino) butane (E-64), Amastatin, Bestatin, Diprotin, Ethylenediamine tetra-acetic acid (EDTA), pepstatin and mixtures thereof.