Patent ID: 8232067
Filing Date: 2012-07-31
Classification: C07K,G01N

Abstract:
1. A method of identifying a candidate compound for decreasing the concentration of an albumin-binding toxin in a subject, the method comprising: contacting (a) a test compound, (b) an FcRn polypeptide or albumin-binding fragment thereof, and (c) an albumin polypeptide or FcRn-binding fragment thereof, under conditions and for a time sufficient to allow binding between the FcRn polypeptide or fragment thereof and the albumin polypeptide or fragment thereof and detecting whether the test compound inhibits binding between the FcRn polypeptide or fragment thereof and the albumin polypeptide or fragment thereof wherein a test compound that inhibits binding between the FcRn polypeptide or fragment thereof and the albumin polypeptide or fragment thereof is a candidate compound for decreasing the concentration of an albumin-binding toxin in a subject.