Patent ID: 6133262
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof ##STR35## wherein E is CR.sup.e or N in which R.sup.e is hydrogen, methyl, methoxy or halo;R.sup.1 is hydrogen or methyl;R.sup.2 is R.sup.2a or R.sup.2b in whichR.sup.2a is --X.sup.2 --(CH.sub.2).sub.n --R.sup.f in which X.sup.2 is a direct bond, methylene or O; n is 1, 2 or 3; and R.sup.f is 5-tetrazolyl, carboxy, [(1-4C)alkoxy]carbonyl or hydroxymethyl;R.sup.2b is --X.sup.2 --(CH.sub.2).sub.m --NR.sup.a R.sup.b in which X.sup.2 is a direct bond, methylene or O; m is 1, 2 or 3; provided that when m is 1, then X.sup.2 is a direct bond; and R.sup.a and R.sup.b are independently hydrogen or (1-3C)alkyl or the group NR.sup.a R.sup.b is pyrrolidino, piperidino or morpholino;R.sup.3 is --X.sup.3 --(CH.sub.2).sub.s --NR.sup.s R.sup.t in which X.sup.3 is a direct bond, methylene or O; s is 1 or 2; provided that when s is 1, then X.sup.3 is a direct bond; and R.sup.s and R.sup.t are independently hydrogen or (1-3C)alkyl or the group NR.sup.s R.sup.t is pyrrolidino, piperidino or morpholino; andR.sup.6 is hydrogen, hydroxy or methoxy.