Patent ID: 8202723
Filing Date: 2012-06-19
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant polynucleotide vector comprising a nucleic acid molecule encoding a polyprotein comprising two or more antigens, a first protease-recognition site separating at least two of the two or more antigens, and a protease, linked to at least one of the antigens by a second protease-recognition site, wherein the vector further comprises expression control sequences to drive expression of the polyprotein, wherein the first protease-recognition site, the second protease-recognition site, or both protease-recognition sites each comprise the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 and wherein the first and/or second protease recognition site is heterologous with respect to at least one of the antigens.