Patent ID: 6774251
Filing Date: 2004-08-10
Classification: C07C,Y02P

Abstract:
A method of making 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol having the structure comprising the steps of:condensing a bicyclic ketone having the structure with an allylic phosphine oxide having the structure where Y1, Y2 and R, which may be the same or different, are each a hydroxy-protecting group, to produce a protected 19-nor-pregnacalciferol analog having the structure thereafter cleaving the protecting group R to form 22-alcohol having the structure converting said 22-alcohol to an ester having the structure where R1 is a tosyl group or a mesyl group;reducing said ester to obtain 17&bgr;-isopropyl-19-nor-vitamin D analog having the structure and deprotecting said 17&bgr;-isopropyl vitamin D derivative to form 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol.