Patent ID: 6506799
Filing Date: 2003-01-14
Classification: A61P,C07C,C07D,C07F,Y10S

Abstract:
A method for treating or preventing a cardiovascular disease in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of a formula I: or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable vehicle, wherein:R1, R2, R3, and R4 are independently selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, and benzyl; or R1, R2, and the carbon to which they are attached are taken together to form a (C3-C7)cycloalkyl group; or R3, R4, and the carbon to which they are attached are taken together to form a (C3-C7)cycloalkyl group; or R1, R2, and the carbon to which they are attached and R3, R4, and the carbon to which they are attached are taken together to form a (C3-C7)cycloalkyl group, with the proviso that none of R1, R2, R3, or R4 is â€”(CH2)0-4Câ‰¡CH; n and m are independent integers ranging from 0 to 4; K1 and K2 are independently selected from the group consisting of â€”CH2OH, â€”C(O)OH, â€”C(O)OR5, â€”OC(O)R5, â€”SO3H, R5 is selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, and benzyl; each R6 is independently selected from the group consisting of H, (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl; R7 is selected from the group consisting of H, (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl; and with the proviso that when n and m are both 1 or both 0, then K1 and K2 are not both X, wherein X is selected from the group consisting of â€”COOH, â€”C(O)OR5,