Patent ID: 7585966
Filing Date: 2009-09-08
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A composition consisting of a polynucleotide and a pharmaceutically acceptable carrier, wherein the polynucleotide (a) has a sequence of at least 10 nucleotides that specifically hybridizes to a first nucleotide sequence within an accessible region of the RNA component of a human telomerase (hTR), wherein the accessible region is selected from the group consisting of nucleotides 290-319 and nucleotides 350-380 of hTR (SEQ ID NO:16), (b) does not hybridize to a second nucleotide sequence within the template region of the hTR, said template region being nucleotides 46-55 of SEQ ID NO:16, and (c) is effective to inhibit the synthesis of telomeric DNA by telomerase.