Patent ID: 6352994
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound of formula I or a salt thereof: wherein:R is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C2-6alkenyloxy or C2-6alkynyloxy, and when R is not hydrogen, R is optionally independently substituted by one or more halogen atoms or hydroxy, cyano or amino groups; V is CH; W is O; X is a five-membered heteroaromatic group containing one, two, three or four heteroatoms independently selected from N, O and S providing that not more than one heteroatom is selected from O and S, the heteroaromatic group being unsubstituted or substituted with one or more groups independently selected from halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C4-6cycloalkenyl and CF3; Y is hydrogen, NR1R2, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, Ar, O(CH2)nAr1 or CkH2k-4Ar2; R1 and R2 are independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl and (CH2)mAr3, Ar is thienyl, furyl or a six-membered heteroaromatic ring containing one or two nitrogen atoms which is unsubstituted or subtituted with one or more groups independently selected from halogen and C1-6alkyl groups and which is optionally fused to a benzene ring; or napththyl or phenyl rings which rings are unsubstituted or substituted with one or more groups independently selected from halogen, cyano, amino, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, CF3, CF3O, C1-6alkoxy, C2-6alkenyloxy, C2-6alkynyloxy, C1-6alkythio, C2-6alkenylthio, C2-6alkynylthio, hydroxy, hydroxyC1-6alkyl, NR3R4, OC(O)NR3R4, C1-6alkoxyphenylC1-6alkoxy, cyanoC1-6alkyl, cyanoC2-6alkenyl, cyanoC2-6alkynyl, pyridil, phenyl, C1-6alkoxycarbonyl, C1-6alkoxycarbonylC1-6alkyl, C1-6alkoxycarconylC2-6alkenyl, C1-6alkoxycarbonylC2-6alkynyl and â€”O(CH2)pOâ€” and which is optionally fused to a benzene ring; Ar1, Ar2, and Ar3 are independently selected from pyridyl; and phenyl which is unsubstituted or substituted with one or more groups independently selected from halogen, cyano, amino, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, CF3, C1-6alkoxy, C2-6alkenyloxy, C2-6alkynyloxy, C1-6alkylthio, C2-6alkenylthio, C2-6alkynylthio and â€”O(CH2)pOâ€”; Z is Ar4; R3, and R4, are independently as defined for R1 and R2; Ar4 is phenyl which is unsubstituted or subtituted with one or more groups independently selected from halogen, cyano, amino, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, CF3, C1-6alkoxy, C2-6alkenyloxy, C2-6alkynyloxy, C1-6alkythio, C2-6alkenylthio, C2-6alkynylthio and â€”O(CH2)pOâ€”; k is 2; m and n are 1; and p is 1; or 2.