Patent ID: 6379965
Filing Date: 2002-04-30
Classification: A61K,C07K,C12N

Abstract:
A multifunctional molecular complex useful for transfer of a nucleic acid composition to cells, wherein said multifunctional molecular complex comprises:A) a nucleic acid composition; and B) a transfer moiety comprising (i) one or more cationic polyamine components, wherein each cationic polyamine is non-covalently bound to said nucleic acid composition and comprises from three to twelve nitrogen atoms; and (ii) one or more endosome membrane disruption promoting components attached to at least one nitrogen atom of at least one of said polyamine components through an alkyl, carboxamide, carbamate, thiocarbamate, or carbamoyl bridging group, said one or more endosome membrane disruption promoting components independently selected from (a) at least one lipophilic long chain alkyl group or (b) a fusogenic peptide, cholic acid or cholesteryl or a derivative thereof.