Patent ID: 8465484
Filing Date: 2013-06-18
Classification: A61B,A61N,C12N

Abstract:
1. A method of treating a subject suffering from a neoplasia, said method comprising: identifying a treatment area in the subject, wherein the treatment area comprises neoplasia; administering a first therapeutically effective amount of nanoparticles to the subject in need thereof such that at least some of the nanoparticles come in close proximity to neoplastic cells of the neoplasia; positioning at least one electrode into or adjacent the neoplastic cells; applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to cause non-thermal irreversible electroporation of the neoplastic cells; and orienting the nanoparticles in relationship to the electric field such that the electric field is enhanced, the treatment area is enlarged, a more precisely defined treatment margin is achieved, or tumor margins are more selectively treated.