Patent ID: 6353055
Filing Date: 2002-03-05
Classification: A61K,A61P,C08F,C08L

Abstract:
A composition comprising a polynucleotide and a polymer of a plurality of covalently bound polymer segments, wherein the polynucleotide and polymer are not linked covalently; and the polymer segments comprise:(a) at least one polycation segment which is a cationic homopolymer, copolymer, or block copolymer or a quaternary salt thereof wherein the copolymer comprises at least one aminoalkylene monomer selected from the group consisting of: (i) a tertiary amino monomer of the formula: â€ƒand (ii) a secondary amino monomer of the formula: â€ƒin which: each of R1, R4, R5, R6, and R8, taken independently of the other, is hydrogen, alkyl of 2 to 8 carbon atoms, another A monomer, or another B monomer; each of R2, R3, and R7, taken independently of the other, is a straight or branched chain alkanediyl of the formula: in which z has a value of from 2 to 8; and (b) at least one straight or branched chained polyether segment of from about 5 to about 400 monomeric units which polyether segment is: (i) a homopolymer of a first alkyleneoxy monomer â€”OCnH2nâ€” or (ii) a copolymer or block copolymer of said first alkyleneoxy monomer and a second different alkyleneoxy monomer â€”OCmH2mâ€”, â€ƒin which n has a value of 2 or 3 and m has a value of from 2 to 4.