Patent ID: 7098037
Filing Date: 2006-08-29
Classification: A61B,G01N,Y10T

Abstract:
1. A non-invasive method for determining the presence, concentration, or both of an analyte in tissue of a specific subject comprising the steps of: a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths, an input element, an output element and a spectrum analyzer; b) providing an apparatus for making a direct measurement of the presence, concentration or both of the analyte; c) coupling said input and output elements to said tissue; d) irradiating said tissue through said input element with multiple wavelengths of infrared energy with resulting absorption of at least some of said wavelengths; e) collecting at least a portion of the non-absorbed infrared energy with said output element followed by determining the intensities of said infrared energy; and f) determining the presence, concentration, or both of the analyte in the tissue of said specific subject utilizing a multivariate calibration model, based on reference measurements from multiple subjects and one or more reference measurements from said specific subject, wherein each of said reference measurements includes infrared spectroscopic and corresponding direct measurement of a presence, concentration, or both of the analyte.