Patent ID: 6448429
Filing Date: 2002-09-10
Classification: A61P,C07F

Abstract:
A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein:R1 and R2 are selected from the group consisting of: C1-10alkyl(Ra)0-7, C2-10alkenyl(Ra)0-7, and Aryl(Ra)0-3; wherein each Ra independently represents a member selected from the group consisting of: Aryl, OH, halogen, CN, CO2H, CO2C1-6alkyl, CO2C2-6alkenyl, OC1-10alkyl, C(O)C1-6alkyl, S(O)yC1-6alkyl, C1-6alkyl, C1-6haloalkyl, S(O)yNR3â€²R4â€², wherein y is 0, 1, or 2, C(O)NR3â€²R4â€², NR3â€²R4â€², wherein each alkyl group in Ra is optionally substituted with 1-7 groups independently selected from halogen, OC1-3 alkyl, CO2H, and CO2C1-3alkyl, and each Aryl in Ra is optionally substituted with 1-3 groups independently selected from C1-3alkyl, halogen, OC1-3 alkyl, CO2H, and CO2C1-3alkyl; Aryl is a 6-14 membered carbocyclic aromatic ring system comprising 1-3 phenyl rings, wherein the phenyl rings are fused together when there is more than one aromatic ring; Y1, Y2, Z1, and Z2 each independently represents â€”(CR3R4)aâ€”Xâ€”(CR3R4)bâ€” wherein a and b are integers 0-2 such that the sum of a and b equals 0, 1, 2, or 3; X represents a bond, O, S(O)y, NR3â€², C(O), OC(O), C(O)O, C(O)NR3â€², NR3â€²C(O) or â€”CH&boxH;CHâ€”, where y is as previously defined; R3 and R4 are independently H, halogen, C1-10alkyl or C1-10haloalkyl; R3â€² and R4â€² are each independently selected from the group consisting of: H, C1-6alkyl, C1-6haloalkyl, OH, C(O)C1-6 alkyl, C(O)Aryl, C(O)Het, C(O)C1-6 haloalkyl, and Aryl; W1 and W2 are each in a position on the aromatic ring adjacent to the â€”CF2P(O)(OH)2 substituent and are each independently selected from the group consisting of: OH, CN, halogen, OC1-6alkyl(Ra)0-7, S(O)yC1-6alkyl(Ra)0-7, with y equal to 0-2, S(O)3H, C1-6alkyl(Ra)0-7, CO2H CO2C1-6alkyl(Ra)0-7, CO2C2-6 alkenyl(Ra)0-7, C(O)C1-6alkyl(Ra)0-7, C(O)NR3â€²R4â€², S(O)yNR3â€²R4â€², NR3â€²R4â€², and Aryl, wherein R3â€² and R4â€² are as defined above; and W1â€² and W2â€² are optionally present on any remaining position on the aromatic ring and are each independently selected from H and from the same groups as W1 and W2.