Patent ID: 7727998
Filing Date: 2010-06-01
Classification: A61K,A61P,C07D

Abstract:
1. A compound of structural formula I-1: or a pharmaceutically acceptable salt thereof, wherein: R R R R each R n is selected from an integer between 1 and 8; W W CY is cyclopentane ring, cyclohexane ring, prrolidine ring, morpholine ring, piperazine ring, pyperidine ring, benzene ring, dihydropyridine ring, pyridine ring, pyrazine ring, pyrimidine ring, pyrrole ring, pyrazole ring, imidazole ring, triazole ring, tetrazole ring, oxazole ring, oxadiazole ring, oxazolidine ring and thiazole ring; which is optionally substituted with two or more substituents selected from Group α, Y with the proviso that not all of Y Ar is a benzene ring, a pyridine ring, a pyrazine ring or a pyrimidine ring, unsubstituted or substituted with one or two substituents selected from Group β: each Group α is independently selected from: halogen, hydroxyl, amino, nitro, oxo, mono-lower alkylamino, di-lower alkylamino, optionally halogen-substituted lower alkyl, optionally fluorine-substituted lower alkyloxy, lower cycloalkyloxy, lower alkyloxycabonyl, (lower alkyloxycarbonyl)amino, (lower alkyloxycarbonyl)lower alkylamino, lower alkylcarbonyl, lower alkylcarbonyloxy, (lower alkylcarbonyl)amino, (lower alkylcarbonyl)lower alkylamino, carbamoyl, mono-lower alkylcarbamoyl, di-lower alkylcarbamoyl, carbamoylamino, mono-lower alkylcarbamoylamino, di-lower alkylcarbamoylamino, (mono-lower alkylcarbamoyl)lower alkylamino, (di-lower alkylcarbamoyl)lower alkylamino, carbamoyloxy, mono-lower alkylcarbamoyloxy, di-lower alkylcarbamoyloxy, lower alkylsulfonyl, lower alkylsulfonylamino, sulfamoyl, mono-lower alkylsulfamoyl, di-lower alkylsulfamoyl, sulfamoylamino, (mono-lower alkylsulfamoyl)amino, (di-lower alkylsulfamoyl)amino, (mono-lower alkylsulfamoyl)lower alkylamino and (di-lower alkylsulfamoyl)lower alkylamino; and each Group β is independently selected from: nitro, aryloxy, lower cycloalkyl, lower cycloalkyloxy, lower alkylenedioxy, halogen, hydroxyl, optionally hydroxyl- or fluorine-substituted lower alkyl and optionally fluorine-substituted lower alkyloxy.