Patent ID: 6723730
Filing Date: 2004-04-20
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein:A is absent or is selected from the group consisting of O, S, NRA, NRACRBRBâ€², CRBRBâ€²NRA, â€”CRA&boxH;CRBâ€”, and C3H4; where RA, RB, and RBâ€² are independently selected at each occurrence from hydrogen or alkyl; Z is oxygen or sulfur; each R3 and R4 independently (a) selected from the group consisting of hydrogen; halogen; hydroxy; amino; cyano; nitro; â€”COOH; â€”CHO, optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted alkoxy; optionally substituted alkylthio; optionally substituted alkyl ketone; optionally substituted alkylester; optionally substituted alkylsulfinyl; optionally substituted alkylsulfonyl; optionally substituted mono- or di-alkylcarboxamide; optionally substituted â€”S(O)nNHalkyl; optionally substituted â€”S(O)nN(alkyl)(alkyl); optionally substituted â€”NHC(&boxH;O)alkyl; optionally substituted â€”NC(&boxH;O)(alkyl)(alkyl); optionally substituted â€”NHS(O)nalkyl; optionally substituted â€”NS(O)n(alkyl)(alkyl); optionally substituted saturated heterocyclic ring or partially unsaturated heterocycle of from 5 to 8 atoms, which saturated heterocyclic ring or partially unsaturated heterocycloalkyl contains 1, 2, or 3 heteroatoms selected from N, O, and S; optionally substituted aryl having from 1 to 3 rings; or optionally substituted heteroaryl, said heteroaryl having from 1 to 3 rings, 5 to 8 ring members in each ring and, in at least one of said rings, from 1 to about 3 heteroatoms per ring independently selected from the group consisting of N, O, and S; or (b) joined to a R3 and R4 not attached to the same carbon may be joined to form an optionally substituted aryl ring, a saturated or partially unsaturated carbocyclic ring of from 5 to 8 members, which carbocyclic ring is optionally substituted, or a saturated, partially unsaturated, or aromatic heterocyclic ring of from 5 to 8 members, which heterocyclic ring is optionally substituted and contains 1, 2, or 3 heteroatoms selected from N, O, and S; Ar1 is selected from the group consisting of: (a) cyclohexyl, cyclopentyl, piperidinyl, piperazinyl, phenyl, pyrrolyl, furanyl, thienyl, pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimdyl, pyrazinyl, benzimidazolyl naphthyl, indolyl, isoindolyl, benzfuranyl, isobenzofuranyl, benzo[b]thiophenyl, benz[d]isoxazoly, quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, and quinoxalinyl, each of which is optionally mono-, di-, or trisubstituted with R5; and (b) bicyclic oxygen-containing groups of the formula: â€ƒoptionally mono-, di-, or trisubstituted with R5, where L represents point of attachment and may be at any point on the benzene ring, and the oxygen-containing ring of the bicyclic oxygen-containing group consists of from 5 to 8 ring atoms, contains 1 or 2 oxygen atoms and remaining ring atoms are carbon; Ar2 is selected from the group consisting of: (a) cyclohexyl, cyclopentyl, piperidinyl, piperazinyl, pyrrolyl, furanyl thienyl, pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimdyl, benzimidazolyl, naphthyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzo[b]thiophenyl, benz[d]isoxazoly, quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, and quinoxalinyl, each of which is optionally mono-, di-, or trisubstituted with R5; and (b) bicyclic oxygen-containing groups of the formula: â€ƒoptionally mono-, di-, or trisubstituted with R5, where L represents point of attachment and may be at any point on the benzene ring, and the oxygen-containing ring of the bicyclic oxygen-containing group consists of from 5 to 8 ring atoms, contains 1 or 2 oxygen atoms and remaining ring atoms are carbon; R5 is independently selected at each occurence from the group consisting of halogen, nitro, halo(C1-6)alkyl, halo(C1-6)alkoxy, hydroxy, amino, C1-6alkyl substituted with 0-2 R6, C2-6alkenyl substituted with 0-2 R6, C2-6alkynyl substituted with 0-2 R6, C1-6alkoxy and Y; R6 is independently selected at each occurence from the group consisting of halogen, hydroxy, cyano C1-4alkyl, C1-4alkoxy, â€”S(O)n(C1-4alkyl), halo(C1-4)alkly, halo(C1-4)alkoxy, CO(C1-4alkyl), CONH(C1-4alkyl), CON(C1-4alkyl1) (C1-4alkyl2) where alkyl1 and alkyl2 may be joined to form a saturated heterocyclic ring of from 5 to 8 ring atoms and containing 1, 2, or 3 heteroatoms independently selected from N, O, and S, â€”XR7, and Y; X is independently selected at each occurence from the group consisting of â€”CH2â€”, â€”CHR8â€”, â€”Oâ€”, â€”S(O)nâ€”, â€”NHâ€”, â€”NR8â€”, â€”C(&boxH;O)â€”, â€”C(&boxH;O)Oâ€”, â€”C(&boxH;O)NHâ€”, â€”C(&boxH;O)NR8â€”, â€”S(O)nNHâ€”, â€”S(O)nNR8â€”, NHC(&boxH;O)â€”, â€”NR8C(&boxH;O)â€”, â€”NHS(O)nâ€”, and â€”NR8S(O)nâ€”; R7 and R8 are independently selected at each occurrence from hydrogen, and straight, branched, and cyclic alkyl groups, and (cycloalkyl)alkyl groups, said straight, branched, and cyclic alkyl groups, and (cycloalkyl)alkyl groups consisting of 1 to 8 carbon atoms, and containing zero or one or more double or triple bonds, each of which 1 to 8 carbon atoms is unsubsitituted or substituted with one or more substituent(s) independently selected from oxo, hydroxy, halogen, amino, cyano, nitro, haloalkyl, haloalkoxy, â€”O(alkyl), â€”NH(alkyl), â€”N(alkyl)(alkyl), â€”NHC(O)(alkyl), â€”N(alkyl)C(O)(alkyl), â€”NHS(O)n(alkyl), â€”S(O)n(alkyl), â€”S(O)nNH(alkyl), â€”S(O)nN(alkyl3)(alkyl4) where alkyl3 and alkyl4 are opitionally joined to form a saturated heterocyclic ring consisting of from 5 to 8 ring atoms and containing 1, 2, or 3 heteroatoms independently selected from N, O, and S, and Yâ€²; Y and Yâ€² are independently selected at each occurrence from 3- to 8-membered carbocyclic or heterocyclic groups which are saturated, unsaturated, or aromatic, which may be further substituted with one or more substituents independently selected from halogen, oxo, hydroxy, amino, nitro, cyano, alkyl, alkoxy, haloalkyl, haloalkoxy, mono- or dialkylamino, and alkylthio; wherein said 3- to 8-memberered heterocyclic groups contain one or more heteroatom(s) independently selected from N, O, and S; n is independently chosen at each occurrence from 0, 1, and 2.