Patent ID: 6316631
Filing Date: 2001-11-13
Classification: C07D

Abstract:
A process for preparing a compound of the formula ##STR6##wherein R.sup.1 is (C.sub.1 -C.sub.4)alkyl; R.sup.2 is methyl or ethyl; and R.sup.3, R.sup.4 and R.sup.5 are selected, independently, from (C.sub.1 -C.sub.4)alkyl and (C.sub.1 -C.sub.4)alkoxy; or a pharmaceutically acceptable salt thereof; comprising reacting a compound of the formula ##STR7##wherein R.sup.1 and R.sup.2 are defined as above, with a compound of the formula ##STR8##wherein R.sup.3, R.sup.4 and R.sup.5 are defined as above, in the presence of a base that is capable of deprotonating the compound of formula III, in the presence of copper (I) bromide, copper (I) chloride, or copper (I) iodide and pyridine, and then optionally converting the resulting compound of formula I into a pharmaceutically acceptable salt of such compound.