Patent ID: 6171585
Filing Date: 2001-01-09
Classification: A61K,C07K

Abstract:
A method for transplanting a histoincompatible organ allograft into an HLA-sensitized transplant candidate, consisting of(I) administering to the transplant candidate prior to transplantation an amount of an anti-HLA antibody depleting agent selected from the group consisting of IVIg and an IgG fraction of IVIg, immunosuppressively effective to substantially(a) reduce the serum level of anti-HLA antibodies,(b) result in a negative crossmatch of the transplant candidate with potential organ donors relative to the crossmatch attained without the administration of the agent, and(c) enhance organ allograft survival in the transplant candidate; and(II) transplanting an organ allograft into the transplant candidate.