Patent ID: 6765096
Filing Date: 2004-07-20
Classification: A61K,A61P,C07D

Abstract:
A compound represented by the formula (I): wherein is â€”N(COOCR3R2OCOR1)â€”, and Xâ€² is â€”Oâ€”,R1 is lower alkyl sustituted with 1 or 2 groups selected from the group consisting of â€”CONH2, â€”CONHCH3, â€”CONHC2H5, â€”OCONH2, â€”OCONHCH3, â€”OCONHC2H5, â€”(NHCOCRRâ€²)mNHCOCH3, â€”(NHCOCRRâ€²)mNHCOC2H5, â€”CSNH2, â€”(OCH2CH2)nOH, â€”OCH3, â€”(OCH2CH2)nOCH3, â€”COCH3, â€”COC2H5, â€”OCOCH3, â€”OCOC2H5, â€”NHOH, â€”NHCONH2, â€”NHCSNH2, â€”NHSO2CH3, â€”N(CO2CH3)2, â€”SO2NH2, â€”SOCH3, â€”SO2CH3, â€”OCH2CONH2, â€”OCH2CON(CH3)2, â€”SO2N(CH3)2, â€”PO(OCH3)2, â€”NHCSNHC2H5, â€”CH&boxH;NNHCONH2, â€”CH&boxH;NNHCSNH2, or â€”CH&boxH;NNHSO2CH3, triazolyl and tetrazolyl (wherein R and Râ€² are each independently hydrogen or lower alkyl, m is an integer of 0 to 2, and n is an integer of 1 or 2), R2 and R3 are each independently hydrogen or lower alkyl, Y and Yâ€² are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted, sulfamoyl, optionally substituted amino, optionally substituted aryl or optionally substituted 5-membered or 6-membered heterocycle, ring A, and ring B are each an optionally substituted benzene ring, and ring C is pyridine, both V1 and V2 are a single bond, or a pharmaceutically acceptable salt or a solvate thereof.