Patent ID: 6420426
Filing Date: 2002-07-16
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: or pharmaceutically acceptable salts thereof whereinA is a C1-C4 alkylene group optionally substituted with C1-C2 alkyl or mono- or disubstituted with halogen; X is oxygen or sulfur; R1, R2, R3 and R4 are each independently hydrogen, halogen, or nitro, or an alkyl group of 1-6 carbon atoms optionally substituted with one or more halogens; OR7, SR7, S(O)R7, S(O)2R7, C(O)N(R7)2, or N(R7)2, wherein each R7 is independently hydrogen, an alkyl group of 1-6 carbon atoms (which may be substituted with one or more halogens) or benzyl, where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, amino, andmono- or di(C1-C6)alkylamino; phenyl or heteroaryl each of which phenyl or heteroaryl is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, amino, and morno- or di(C1-C6)alkylamino; phenoxy where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, amino, and mono- or di(C1-C6) alkylamino; or a group of the formula â€ƒwhere J is a bond, CH2, oxygen, or nitrogen; and each r is independently 2 or 3; and Ar represents aryl which is optionally substituted with up to five groups.