Patent ID: 7354714
Filing Date: 2008-04-08
Classification: A61K,C07K,C12N

Abstract:
1. A method of making an antibody against a plurality of papilloma virus types, comprising: introducing into a mammal a plurality of DNA clones from a plurality of HPV types, wherein each clone of said plurality of DNA clones comprises an expression vector comprising DNA that encodes at least a portion of a L1 structural protein of a human papilloma virus comprising the coding sequence of at least one naturally occurring epitope of said papilloma virus or at least one randomly generated heterologous sequence which is derived from the coding sequence of a naturally occurring epitope by the exchange of one or more nucleotides; testing the mammal to detect antibodies against a plurality of papilloma virus types generated by introducing the plurality of DNA clones into the mammal; and harvesting antibodies from the mammal.