Patent ID: 6743924
Filing Date: 2004-06-01
Classification: A61P,C07D

Abstract:
A method for producing a compound of the formula: whereinRa1 and Ra2 are each a hydrogen atom, a substituted hydroxy, a substituted thiol, a substituted amino, an optionally substituted hydrocarbon group, or an acyl; Ra3 is a group of the formula: wherein Ra4 and Ra5 are each a hydrogen atom, an optionally substituted hydroxy, an optionally substituted thiol, an optionally substituted amino, an optionally substituted hydrocarbon group, or an acyl, or Ra4 and Ra5 in combination form oxo, Ra6 an optionally substituted aromatic group, and ma is an integer of 0 to 10; or two or three from Ra1, Ra2 and Ra3 form an optionally substituted ring, together with the adjacent carbon atom; and Ra7 and Ra8 are each a hydrogen atom, a halogen, an optionally substituted hydroxy, an optionally substituted thiol, an optionally substituted amino, an optionally substituted hydrocarbon, or an acyl, which method comprises reacting a compound of the formula: wherein Xa is a leaving group and other symbols are as defined above, or a salt thereof, and compound of the formula: wherein each symbol is as defined above, or a salt thereof,(1) in a secondary or tertiary alcohol in the presence of a base, or (2) in the absence of a base.