Patent ID: 9173894
Filing Date: 2015-11-03
Classification: A61K,A61P,C12N

Abstract:
1. A method for treating a keloid, or preventing the formation, reformation, or growth of a keloid after an injury to the skin, in a subject in need thereof, which comprises administering to the subject by one or more injections at the site of the keloid or of the injury to the skin, a composition which comprises a modified oligonucleotide consisting of 12-30 linked nucleosides, at least a 12 nucleobase sequence portion of which is present within a region selected from nucleotides 553-611, 718-751, 1388-1423, 1457-1689, 2040-2069, 2120-2147, 2728-2797, 2267-2301, 1394-1423, 1469-1508, 1559-1605, 1659-1689, 2100-2129 and 1399-1423 of SEQ ID NO: 9, or a salt or ester thereof, in an amount effective to treat, or to prevent the formation, reformation, or growth of, the keloid, wherein the effective amount is from 0.1 to 50 mg of the modified oligonucleotide per injection per linear centimeter of the keloid or of the injury to the skin.