Patent ID: 8637564
Filing Date: 2014-01-28
Classification: A61K,A61N,A61P,C12N,G01N

Abstract:
1. A method of inducing or aggravating stress in a cell's endoplasmic reticulum (ER) to trigger apoptosis, comprising: inhibiting SERCA activity selectively in said cell without inhibiting COX-2 activity; and elevating the expression of CHOP in said cell, wherein, the combination of inhibiting SERCA activity and elevating CHOP expression results in a condition favorable for initiation of apoptosis in the cell, the step of selectively inhibiting SERCA comprises administering a pharmaceutically effective amount of an ER stress aggravating agent, and wherein said ER-stress aggravating agent comprises a compound having a formula: wherein R R R R R 12 is hydrogen, acetyl, acyl, alkyl, fluoroalkyl, difluoroalkyl, trifluoroalkyl, polyfluoroalkyl, hydroxyalkyl, carboxyalkyl; aminoacyl, aminoalkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl, with the proviso that the compound 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide is excluded.