Patent ID: 6455582
Filing Date: 2002-09-24
Classification: A61P,C07C

Abstract:
A compound of formula (I): R1 is H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, phenyl, (phenyl)C1-4 alkyl, (phenyl)C3-4 alkenyl, (phenyl)C3-4 alkynyl, (C3-8 cycloalkyl)-C1-4 alkyl, (C3-8 cycloalkyl)C3-4 alkenyl, (C3-8 cycloalkyl)C3-4 alkynyl, C3-8 heterocyclic radical, (C3-8 heterocyclic radical)C1-4 alkyl, (C3-8 heterocyclic radical)C3-4 alkenyl, (C3-8 heterocyclic radical)C3-4 alkynyl, (CH2)2-4 ORC or (CH2)2-4 NRCRD; R2 is H, C1-4 alkyl, phenyl, C3-6 cycloalkyl, C3-6 heterocyclic radical, or (C3-6 cycloalkyl) methyl; each of R3 and R4 is independently selected from H, F, NO2, Br and Cl; R5 is selected from H and F; R6 is H, F, Cl or CH3; each of RC and RD is independently selected from H, C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C3-6 cycloalkyl, and phenyl; or NRCRD may be a piperidino, morpholino, or N-(C1-6 alkyl)piperazino ring; wherein each hydrocarbon radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, hydroxyl, amino, (amino)sulfonyl, and NO2; and wherein each heterocyclic radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, C1-4 alkyl, C3-6 cycloalkyl, C3-4 alkenyl, C3-4 alkynyl, phenyl, hydroxyl, amino, (amino)sulfonyl, and NO2, wherein each substituent alkyl, cycloalkyl, alkenyl, alkynyl or phenyl is in turn optionally substituted with between 1 and 2 substituents independently selected from halo, C1-2 alkyl, hydroxyl, amino, and NO2; or a pharmaceutically acceptable salt or C1-8 ester thereof.