Patent ID: 7179830
Filing Date: 2007-02-20
Classification: A61P,C07D

Abstract:
1. A compound of the formula I or II where R1 is a substituted phenyl of formula: where R5 and R6 are each independently selected from the group consisting of hydrogen, methyl, ethyl, cycloalkyl having 3, 4 or 5 carbon atoms, vinyl, ethynyl, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, SF R7 is alkyl having 1, 2 or 3 carbon atoms, trifluoromethyl or CH X is CH n is zero, one or two; provided that R5 and R6 are not both hydrogen at the same time; or R1 is a substituted 3-thienyl of formula: R2 and R3 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, methyl, CN, OH, —O—CH R8 is methyl, trifluoromethyl or CH Y is CH m is zero, one or two; and R4 is selected from the group consisting of hydrogen, methyl, ethyl, cyclopropyl, cyclopropylmethyl and CH or a pharmaceutically acceptable salt or a trifluoroacetic acid salt of a compound of formula I or formula II.