Patent ID: 8476438
Filing Date: 2013-07-02
Classification: C07B,C07D

Abstract:
1. A method for preparing 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin comprising: treating a composition comprising 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin and a compound represented by formula (5): with a catalyst and hydrogen or a formic acid or its salt as a hydrogen source, such that compound (5) is catalytically reduced to form 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin, and compound (5) is not detectable under standard HPLC conditions following catalytic reduction.