Patent ID: 6486143
Filing Date: 2002-11-26
Classification: A61P,C07F

Abstract:
A compound selected from those of formula (I): wherein: R1 represents halogen or trifluoromethyl, R2 represents hydrogen or alkyl or cycloalkyl, R3 represents alkyl, cycloalkyl, aryl, arylalkyl, alkoxy, aryloxy, arylalkoxy, hydroxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylcarbonyl, arylcarbonyl or arylalkylcarbonyl or NHR6 (wherein R6 represents hydrogen or alkyl, cycloalkyl, aryl, alkylcarbonyl, arylcarbonyl, arylalkyl or arylalkylcarbonyl), or R2 and R3 together form with the nitrogen atom carrying them a ring having 5 to 6 carbon atoms, in which one of the carbon atoms can be replaced by oxygen, nitrogen or sulphur or by SO, SO2 or NRa (wherein Ra represents hydrogen or alkyl, cycloalkyl, aryl or arylalkyl), R4 and R5, which may be identical or different, represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl or a group (wherein R7 and R8, which may be identical or different, represent hydrogen or alkyl, cycloalkyl or aryl), it being understood that: â€œalkylâ€  is understood to mean a linear or branched alkyl group containing from 1 to 6 carbon atoms, â€œalkoxyâ€  is understood to mean a linear or branched alkoxy group containing from 1 to 6 carbon atoms, â€œcycloalkylâ€  is understood to mean a cyclic alkyl group containing from 3 to 8 carbon atoms, â€œarylâ€  is understood to mean the groups phenyl or naphthyl, it being possible for those groups to be unsubstituted or substituted by from 1 to 3 groups selected from alkyl, cycloalkyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, polyhaloalkyl, SO2NR9R10 (wherein R9 and R10, which may be identical or different, represent a hydrogen atom or an alkyl, cycloalkyl or aryl group) and halogen atoms, its enantiomers and diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid or base.