Patent ID: 6593327
Filing Date: 2003-07-15
Classification: A61P,C07B,C07C,C07D

Abstract:
A compound of Formula I: in which:R1 is a group of Formula (a): â€ƒwherein within Formula (a): X1 is â€”C(O)â€”; R5 is hydrogen or as defined together with R9; R7 is hydrogen; R9 is (i) (C1-6)alkyl or R9 and R5 together with the carbon atom to which both R9 and R5 are attached form (C3-8)cycloalkylene or (C3-8)heterocycloalkylene; and R11 is â€”X4X5R18, wherein X4 is â€”C(O)â€”, X5 is a bond, â€”Oâ€”or â€”NR19â€” where R19 is hydrogen or (C1-6)alkyl and R18 is phenyl, wherein said phenyl ring is substituted by: (i) â€”R22 where R22 is hetero(C3-12)cycloalkyl(C0-6)alkyl, or (ii) â€”X3OR22, X3NR22R23, â€”X3NR23C(O)R22, â€”X3NR23C(O)OR22, â€”X3NR23S(O)2R22, â€”X3S(O)2R22, â€”X3C(O)R22 or â€”X3NR23C(O)NR22R23, wherein X3 is a bond or (C1-6)alkylene, R22 is hetero(C3-12)cycloalkyl(C0-6)alkyl and R23 at each occurrence independently is hydrogen or (C1-6)alkyl; wherein within R11 any alicyclic or aromatic ring system present may be substituted further by 1 to 5 radicals independently selected from (C1-6)alkyl, (C1-6)alkylidene, cyano, halo, halo-substituted (C1-4)alkyl, nitro, â€”X3NR12R12, â€”X3NR12C(O)OR12, â€”X3NR12C(O)NR12R12, â€”X3NR12C(NR12)NR12R12, â€”X3OR12, â€”X3SR12, â€”X3C(O)OR12, â€”X3C(O)NR12R12, â€”X3S(O)2NR12R12, â€”X3P(O)(OR3)OR12, â€”X3OP(O)(OR3)OR12, â€”X3NR12C(O)R13, â€”X3S(O)R13, â€”X3S(O)2R13 and â€”X3C(O)R13, wherein X3 is a bond or (C1-6)alkylene, R12 at each occurrence independently is hydrogen, (C1-6)alkyl or halo-substituted (C1-3)alkyl and R13 is (C1-6)alkyl or halo-substituted (C1-3)alkyl; R3 is hydrogen or as defined together with R4; and R4 is (i) hydrogen or R4 and R3 taken together with the carbon atom to which both R4 and R3 are attached form (C3-8)cycloalkylene or (C3-8)heterocycloalkylene, wherein said (C3-8)cycloalkylene or (C3-8)heterocycloalkylene optionally is substituted with (C1-6)alkyl; or a N-oxide derivative, individual stereoisomer or mixture of stereoisomers, or a pharmaceutically acceptable salt thereof.