Patent ID: 6083960
Filing Date: 2000-07-04
Classification: A61P,C07D,Y10S

Abstract:
A compound formula I ##STR24## wherein A is pyridinyl or phenyl optionally substituted with one or more halogens, amino groups, hydroxyl groups, nitro groups, C.sub.1-6 -alkyl groups or C.sub.1-6 -alkoxy groups;B is phenyl, pyridinyl or naphthyl optionally substituted with one or more halogens, amino groups, hydroxyl groups, C.sub.1-6 -alkyl groups or C.sub.1-6 -alkoxy groups;m is 0, 1, 2, 3, 4, 5 or 6;n is 0, 1, 2 or 3;Y is a valence bond or a group having the formula ##STR25## wherein q and s each independently are 0, 1, 2, 3, 4 or 5 and q+s is 1, 2, 3, 4 or 5;R.sup.1 is hydrogen or C.sub.1-6 -alkyl optionally substituted with halogen, amino, hydroxy or alkoxy;X is .dbd.S, .dbd.O or .dbd.NR.sup.3, wherein R.sup.3 is hydrogen, --C(O)Ph, or --CN;E is a group having the formula ##STR26## wherein p is 0, 1, 2, 3 or 4, r is 1, 2, 3, 4, 5 or 6, Z is --N< or --CH<, D is aryl optionally substituted with one or more halogens, amino groups, hydroxyl groups, C.sub.1-6 -alkyl groups, C.sub.1-6 -alkoxy groups, piperidinyl groups or aryl groups, R.sup.2 is hydrogen or C.sub.1-6 -alkyl optionally substituted with halogen, amino, hydroxy, alkoxy or aryl, with the proviso that if m=0 then Y is not a valence bond; or a pharmaceutically acceptable salt thereof.