Patent ID: 8927232
Filing Date: 2015-01-06
Classification: A61P,C07K

Abstract:
1. A fusion polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide consisting of: (a) TNFR2 component and VEGFR1 component operatively linked to (b) a multimerizing component, wherein the TNFR2 component consists of a fragment of the extracellular domain of TNFR2 comprising the amino acid sequence of cysteine rich domain 1, cysteine rich domain 2, cysteine rich domain 3, and cysteine rich domain 4 of the extracellular domain of TNFR2 in order, and wherein the VEGFR1 component consists of a fragment of the extracellular domain of VEGFR1 comprising the amino acid sequence of Ig-like domain 2 of the extracellular domain of VEGFR1, excluding other Ig-like domains of the extracellular domain of VEGFR1.