Patent ID: 6576264
Filing Date: 2003-06-10
Classification: A61K,B01F,B01J,Y02P,Y10S

Abstract:
A process of preparing a surface modifier-stabilized aqueous suspension of submicron sized surface modified microparticles with an average particle size up to 300 nm and a narrow size distribution, wherein 99% of the microparticles produced are below 500 nm, without particle aggregation or flocculation of a water-insoluble or substantially water-insoluble biologically active compound, said process comprising:(1) dissolving a water-insoluble or substantially water-insoluble biologically active compound in a solvent for said biologically active compound to form a solution; and (2) spraying the solution prepared in (1) into a compressed gas, compressed liquid or supercritical fluid miscible with said solution but antisolvent for said water-insoluble compound in the presence of an agitated aqueous phase and a surface modifier which may be present in said agitated aqueous phase or in a compressed gas, compressed liquid or supercritical fluid or both.