Patent ID: 6870055
Filing Date: 2005-03-22
Classification: A61P,C07D

Abstract:
1. A compound of structural Formula Ia: or a pharmaceutically acceptable salts, hydrates, solvates, crystal forms, or stereoisomers thereof, wherein: R 1 is: (1) (C (2) (C (3) (C (4) halo, wherein halo is fluoro, chloro, bromo, or iodo; R 2 is: (1) (C (2) (CH (3) (CH wherein T is —NH or n is: 1, 2, or 3; m is: 0, 1, or 2; p is: 0 or 1; R 3 is; (1) aryl, wherein aryl is defined as phenyl or naphthyl which is optionally substituted with one, two or three of the substituents selected from the group consisting of: (2) heteroaryl, wherein heteroaryl is defined as a monocyclic or bicyclic aromatic ring of 5 to 10 carbon atoms containing from 1 to 3 heteroatoms selected from O, N or S, and heteroaryl being optionally substituted with one, two, or three substituents selected from the group consisting of: (3) (C (4) (C R 4 and R 4′ are independently: (1) H, (2) (C (3) (C (4) halo, (5) (C (6) R Q is: (1) NR (2) heterocyclyl, wherein heterocyclyl is defined as a monocyclic or bicyclic ring of 5 to 10 carbon atoms which can be aromatic or nonaromatic, wherein the heterocyclyl is attached to the methylene bearing the R (3) NH(C═O)R