Patent ID: 8680064
Filing Date: 2014-03-25
Classification: A01K,A61P,C12N,C12Y

Abstract:
1. A method of treating ischemic heart disease in a mammal, and monitoring progress thereof by imaging, which method comprises the steps of: a) administering to heart tissue of the mammal in need of said treatment an effective amount of a vector in a pharmaceutically-acceptable carrier, the vector comprising, in operable linkage: i) a promoter; and ii) at least one polynucleotide encoding at least two small hairpin RNAs (shRNAs), which are shPHD2 and shASPHD; wherein upon expression of the vector, neo-angiogenesis is induced in the heart tissue, thereby treating the mammal's ischemic heart disease; and b) monitoring progress of the treatment in step a) by imaging.