Patent ID: 6242589
Filing Date: 2001-06-05
Classification: C07H

Abstract:
A compound comprising a plurality of covalently-bound nucleosides, said compound having the formula:(5')N.sub.U -L.sub.1 -[N.sub.U -L.sub.S ].sub.n -N.sub.U -L.sub.2 -N.sub.U (3')wherein:each N.sub.U is, independently, a nucleoside that includes a ribose or deoxyribose sugar portion and a base portion;L.sub.S is a racemic phosphorothioate internucleoside linkage;n is 1-200; andL.sub.1 and L.sub.2 are independently selected such that:L.sub.1 is a Sp phosphorothioate internucleoside linkage, L.sub.2 is a racemic phosphorothioate internucleoside linkage, and said compound has greater than about 60% stereoisomeric purity; orL.sub.1 and L.sub.2 both are Sp phosphorothioate internucleoside linkages and said compound has greater than about 60% stereoisomeric purity; orL.sub.1 is a Rp phosphorothioate internucleoside linkage, L.sub.2 is a racemic phosphorothioate internucleoside linkage, and said compound has greater than about 60% stereoisomeric purity; orL.sub.1 and L.sub.2 both are Rp phosphorothioate internucleoside linkages and said compound has greater than about 60% stereoisomeric purity; orL.sub.1 and L.sub.2, independently, have the formula CH.sub.2 --O--NR or CH.sub.2 --NR--O wherein R is H, alkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, alkynyl having 2 to about 10 carbon atoms; alkaryl having 7 to about 14 carbon atoms, aralkyl having 7 to about 14 carbon atoms.