Patent ID: 9138404
Filing Date: 2015-09-22
Classification: A61K,A61P

Abstract:
1. A method of treating pain in critically ill patients in need thereof, comprising administering to the critically ill patients an intravenous ibuprofen pharmaceutical composition comprising a dosage regimen of about 400 mg to about 800 mg about every 4 to about 6 hours which attains (i) a Cmax from about 20.8 μg/ml to about 75 μg/ml, (ii) a mean AUC of about 36.8 μg·h/ml to about 117.5 μg·h/ml, or (iii) both (i) and (ii); wherein the dosage regimen produces a pharmacokinetic profile in critically ill patients that is not equivalent to a pharmacokinetic profile produced by administration of an intravenous pharmaceutical composition comprising a dosage regimen of ibuprofen of about 400 mg to about 800 mg about 4 to about 6 hours to non-critically ill patients, wherein the-critically ill patients are not being treated for inflammation and are receiving at least one of the following: vasopressor support treatment, mechanical ventilation treatment, a pulmonary artery catheter treatment, an arterial blood pressure catheter treatment, an Intensive Care Unit treatment, packed red blood cells administration, and multiple antibiotics administration; and pain is thereby treated.