Patent ID: 8338613
Filing Date: 2012-12-25
Classification: C07F

Abstract:
1. A process for the preparation of a catalyst having the following formula: wherein X L R′ and R″ are each independently hydrogen or a radical selected from the group consisting of C S A is heteroaryl, substituted or unsubstituted alkyl, heteroalkyl or cycloalkyl; B is hydrogen, C R variant A (i) reacting a compound of the formula (II) wherein PL 1 and PL 2 are the same or different and each denote a phosphine ligand, R′ and R″ are as defined above, and X 1 and X 2 may be the same or different and each denote an anionic ligand with a compound of the formula (III) wherein A and B are as defined above and S 1 to S 4 are substituents which are selected such that the compound of the formula (III) has a pK a ≧6.2 in the presence of a weak base having a pK b in the range of 3.5-7.0 to obtain a compound of the formula (IV) wherein PL 1 , S 1 to S 4 , A, B, X 1 , R′ and R″ are as defined above, (ii) reacting the compound of formula (IV) with a precursor of a non-phosphine neutral electron donor ligand to obtain catalyst (I) or variant B (i) reacting a compound of the formula (V) wherein PL 1 , PL 2 , X 1 , X 2 , R′ and R″ are as defined above with a precursor of a non-phosphine ligand L 1 as defined above to obtain a compound of the formula (VI) wherein L 1 , PL 2 , X 1 , X 2 , R′ and R″ are as defined above, and (ii) reacting the compound of formula (VI) with a compound of the formula (III) wherein S 1 to S 4 , A and B are as defined above, in the presence of a weak base having a pK b in the range of 3.5-7.0.