Patent ID: 8491867
Filing Date: 2013-07-23
Classification: A61B,A61K

Abstract:
1. A method of nuclear medical photography using dual-isotopes, comprising steps of: (a) obtaining a control group, comprising at least one first individual applied with an imaging agent of single-isotope of [ 99m Tc]TRODAT-1 for dopamine transporter; at least one second individual applied with an imaging agent of single-isotope of [ 123 I]ADAM for serotonin transporter; and at least one third individual applied with imaging agents of dual-isotopes of [ 99m Tc]TRODAT-1 and [ 123 I]ADAM; (b) obtaining photos of said first to said third individuals in said control group through single photon emission computed tomography (SPECT), wherein, on obtaining said photo of said first individual through SPECT, an energy window between 126 Kev and 154 Kev is set for said single-isotope of [ 99m Tc]TRODAT-1; and wherein, on obtaining said photo of said third individual through SPECT, an energy window between 129 Kev and 151 Kev is set for [ 99m Tc]TRODAT-1 in said dual-isotopes; (c) processing said photos obtained in step (b) through visual interpretation to obtain a first specific uptake ratio (SUR) of [ a first SUR of [ a second [ a second [ comparing said second [ 99m Tc]TRODAT-1 SUR of said third individual and said second [ 123 I]ADAM SUR of said third individual with said first [ 99m Tc]TRODAT-1 SUR of said first individual and said first [ 123 I]ADAM SUR of said first individual; (d) obtaining a treatment group, comprising at least one fourth individual applied with said dual-isotopes of [ 99m Tc]TRODAT-1 and [ 123 I]ADAM after pretreating said fourth individual with a blocking agent of methylphenidate HCl for dopamine transporter and a blocking agent of fluoxetine for serotonin transporter separately; (e) obtaining photos of said fourth individual in said treatment group through SPECT after pretreating said fourth individual with methylphenidate HCl and Fluoxetine separately; and (f) processing said photos obtained in step (e) through visual interpretation to obtain a third [ a fourth [ a third [ a fourth [ comparing said third and said fourth [