Patent ID: 6416960
Filing Date: 2002-07-09
Classification: A61K,C12Q,G01N

Abstract:
A diagnostic system containing a bioluminescence generating system, comprising:(a) a first composition comprising, in a pharmaceutically acceptable vehicle, a conjugate that comprises a targeted agent that is a luciferase or a luciferin and a targeting agent, wherein: a bioluminescence generating system comprises a luciferase as one component and a luciferin as another component; the conjugate binds to a cell surface receptor; the targeting agent specifically binds to a cell surface protein; and (b) a second composition, comprising, in a pharmaceutically acceptable vehicle: a luciferin or a luciferase, wherein the composition comprises a luciferin if the targeted agent in the first composition is a luciferase, and a luciferase if the targeted agent in the first composition is a luciferin; and (c) a compound that is a spectral shifter that shifts the spectrum of light generated by the bioluminescence generating system.