Patent ID: 6743791
Filing Date: 2004-06-01
Classification: A61P,C07D

Abstract:
A compound of formula Iâ€²: or a pharmaceutically acceptable salt thereof, wherein:Sp is a spacer group comprising a 5-membered heteroaromatic ring, wherein Ring A and Qâ€²R2â€²are attached to Sp at non-adjacent positions; and wherein Sp has up to two R6 substituents, provided that two substitutable carbon ring atoms in Sp are not simultaneously substituted by R6; Z1 is N and Z2 is CH; T is a linker group selected from â€”NHâ€”, â€”CH2â€”, â€”COâ€”, or a saturated or unsaturated C1-6 alkylidene chain which is optionally substituted, and wherein up to two saturated carbons of the chain are optionally replaced by â€”C(O)â€”, â€”C(O)C(O)â€”, â€”CONR7â€”, â€”CONR7NR7â€”, â€”CO2â€”, â€”OC(O)â€”, â€”NR7CO2â€”, â€”Oâ€”, â€”NR7CONR7â€”, â€”OC(O)NR7â€”, â€”NR7NR7â€”, â€”NR7COâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”NR7â€”, â€”SO2NR7â€”, or â€”NR7SO2â€”; Qâ€² is selected from â€”CO2â€”, â€”C(O)NR7â€” or SO2NR7â€”; U is selected from â€”NR7â€”, â€”NR7COâ€”, â€”NR7CONR7â€”, â€”NR7CO2â€”, â€”Oâ€”, â€”CONR7â€”, â€”COâ€”, â€”CO2â€”, â€”OC(O)â€”, â€”NR7SO2â€”, â€”SO2NR7â€”, â€”NR7SO2NR7 â€”, or â€”SO2â€”; m and n are each independently selected from zero or one; R1 is selected from hydrogen, CN, halogen, R, N(R7)2, OR, or OH; R2â€² is selected from â€”(CH2)yCH(R5)2 or â€”(CH2)yCH(R8)CH(R5)2; y is 0-6; R3 is selected from R7, R, â€”(CH2)yCH(R8)R, CN, â€”(CH2)yCH(R8)CH(R5)2, or â€”(CH2)yCH(R8)N(R4)2; each R is independently selected from an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms; each R4 is independently selected from R, R7, â€”COR7, â€”CO2R, â€”CON(R7)2, â€”SO2R7, â€”(CH2)yR5, or â€”(CH2)yCH(R5)2; each R5 is independently selected from R, OR, CO2R, (CH2)yN(R7)2, N(R7)2, OR7, SR7, NR7COR7, NR7CON(R7)2, CON(R7)2, SO2R7, NR7SO2R7, COR7, CN, or SO2N(R7)2; each R6 is independently selected from R7, F, Cl, (CH2)yN(R7)2, N(R7)2, OR7, SR7, NR7COR7, NR7CON(R7)2, CON(R7)2, SO2R7NR7SO2R7, COR7, CN, or SO2N(R7)2; each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group, or two R7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclyl or heteroaryl ring; R8 is selected from R, (CH2)wOR7, (CH2)wN(R4)2, or (CH2)wSR7; and each w is independently selected from 0-4.