Patent ID: 6787545
Filing Date: 2004-09-07
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, and heterocyclic groups, (b) the groups represented by (a) each substituted independently with at least one group selected from non-interfering substituents, wherein the non-interfering substituent is selected from C1 to C8 alkyl, C2 to C8 alkenyl, C2 to C8 alkynyl, C7 to C12 aralkyl, C2 to C8 alkenyloxy, C2 to C8 alkynyloxy, C3 to C8 cycloalkyl, C3 to C8 cycloalkenyl, phenyl, tolyl, xylyl, biphenylyl, C1 to C8 alkyloxy, C2 to C12 alkyloxy alkyl, C2 to C12 alkyloxyalkyloxy, C1 to C12 alkylcarbonyl, C1 to C12 alkylcarbonylamino, C1 to C12 alkyloxyamino, C1 to C12 alkyloxyaminocarbonyl, C1 to C12 alkylamino, C1 to C6 alkylthio, C1 to C12 alkylthiocarbonyl, C1 to C8 alkylsulfinyl, C1 to C8 alkylsulfonyl, C2 to C8 haloalkyloxy, C1 to C8 haloalkylsulfonyl, C1 to C8 haloalkyl, C1 to C8 hydroxyalkyl, â€”C(O)O(C1 to C8alkyl), â€”(CH2)z-Oâ€”(C1 to C8 alkyl) wherein z is an integer from 1 to 8, benzyloxy, aryloxy, arylthio, â€”(CONHSO2R21) wherein R21 is C1 to C6 alkyl or aryl, formyl, amino, amidino, halogen, carboxyl, â€”(CH2)z-COOH wherein z is an integer from 1 to 8, cyano, cyanoguanidino, guanidino, hydrazide, hydrazino, hydroxy, hydroxyamino, nitro, phosphono, â€”SO3H, carbocyclic groups, and heterocyclic groups, or (c) -(L1)-R5 wherein L1 is a divalent linking group of 1 to 18 atom(s) selected from hydrogen atom(s), nitrogen atom(s), carbon atom(s), oxygen atom(s), and sulfur atom(s), and R5 is a group selected from the groups (a) and (b); R2 is a hydrogen atom or a group containing 1 to 4 non-hydrogen atoms; RA is a group represented by the formula: wherein R6 and R7 are independently a hydrogen atom, C1 to C3 alkyl, or a halogen; G1 and G2 are independently an oxygen atom or a sulfur atom; and G3 is â€”NH2 or â€”NHNH2; R3 is -(L2)-(acidic group) wherein L2 is an acid linker having an acid linker length of 1 to 5; R4 is a hydrogen atom, C1 to C6 alkyl aryl, a halogen or aralkyl, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.