Patent ID: 8188307
Filing Date: 2012-05-29
Classification: C07C,C07D

Abstract:
1. A method for producing an optically active β-amino acid of formula (5a), wherein * shows an asymmetric carbon atom and R is OR 2 (R 2 is a hydrocarbon group or a substituted hydrocarbon group) or an amino group, R 1 is a hydrocarbon group, a substituted hydrocarbon group or COOR 9 (R 9 is a hydrocarbon group or a substituted hydrocarbon group); R 3 to R 7 are each independently a hydrogen atom, a hydrocarbon group, a halogen atom, a halogenated hydrocarbon group, a substituted hydrocarbon group, an aliphatic heterocyclic group, a substituted aliphatic heterocyclic group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an alkoxy group, a substituted alkoxy group, an aralkyloxy group, a substituted aralkyloxy group, an aryloxy group, a substituted aryloxy group, an acyl group, an acyloxy group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group, an alkylenedioxy group, a hydroxyl group, a nitro group, an amino group or a substituted amino group; R 3 and R 4 , R 4 and R 5 , R 5 and R 6 , or R 6 and R 7 , taken together, may form a fused ring, with the proviso that either R 3 or R 7 is a hydrogen atom, which method comprises subjecting an enaminoester of formula (4a), wherein R, R 1 and R 3 to R 7 have the same meanings as mentioned above to an asymmetric hydrogenation.