Patent ID: 7932264
Filing Date: 2011-04-26
Classification: A61P,C07D

Abstract:
1. A method for inhibiting the release of one or more cytokines in whole blood, comprising the steps of providing a whole blood culture from a subject or patient, and contacting the whole blood culture with a compound of Formula I in an amount effective to inhibit the release of one or more cytokines in the whole blood culture, wherein R R is cyclopentyl, cyclohexyl, cycloheptyl, allyl, cyclopropylmethyl, 2-furylmethyl, benzoylmethyl, acetylmethyl, ethoxycarbonylmethyl, 2,2,2-trifluoroethyl, benzyl, α-ethoxycarbonylbenzyl, acetyl, propanoyl, butanoyl, benzyloxycarbonyl, 3,4-methylenedioxybenzylaminocarbonyl, 2-methylphenoxy-acetyl, phenylacetyl, cyclopropylacyl, 2-furylacyl, ethylaminoacyl, nicotinoyl, benzoyl, 3-chlorobenzoyl, 4-methylbenzoyl, 2-hydroxybenzoyl, 2-chloro-4-methanesulfonylbenzoyl, 3,5-dimethylbenzoyl, 3-hydroxy-2-methylbenzoyl, 3,4-difluorobenzoyl, 2-phenylpropanoyl, methanesulfonyl, ethanesulfonyl, propanesulfonyl, p-toluenesulfonyl, aminosulfonyl, 2-methoxycarbonyl-6-methylbenzene-sulfonyl, 4-acetylamino-benzenesulfonyl, 5-chloro-1,3-dimethyl-4-pyrazolyl-methyl, 2-(6-methoxy-2-naphthyl)-propanoyl, diethylaminoglyoxylyl, 3-(piperidin-1-yl)propanoyl, phenylaminosulfonyl, benzoylaminosulfonyl, 2-(piperazin-1-yl)ethane-sulfonyl, dimethylaminomethanesulfonyl or 2-pyrimidinyl.