Patent ID: 8143400
Filing Date: 2012-03-27
Classification: C07D

Abstract:
1. A process for the preparation and purification of the cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride comprising: (a) treatment of a cis/trans mixture of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine with an organic sulfonic acid in an organic solvent or a mixture thereof; (b) purification of the mixture obtained at step (a) by recrystallization or pulping in an organic solvent or a mixture thereof; (c) hydrochloric acid salt formation by treatment of the salt obtained at step (b) with hydrochloric acid or treatment with a base and then hydrochloric acid.