Patent ID: 6815429
Filing Date: 2004-11-09
Classification: A61K,A61P,C12N

Abstract:
A method for increasing the immunostimulatory effect of a CpG-containing oligonucleotide, the method comprising introducing into the oligonucleotide a 3â€²-pentose substituted nucleoside at a position selected from the group consisting of 3rd nucleoside 5â€² to the CpG dinucleotide, 4th nucleoside 5â€² to the CpG dinucleotide, 5th nucleoside 5â€² to the CpG dinucleotide, 6th nucleoside 5â€² to the CpG dinucleotide, 2nd nucleoside 3â€² to the CpG dinucleotide, 3rd nucleoside 3â€² to the CpG dinucleotide, 4th nucleoside 3â€² to the CpG dinucleotide, 5th nucleoside 3â€² to the CpG dinucleotide, 6th nucleoside 3â€² to the CpG dinucleotide, and combinations thereof.