Patent ID: 8617605
Filing Date: 2013-12-31
Classification: A61K

Abstract:
1. A pharmaceutical composition for controlled release of at least one therapeutically, prophylactically and/or diagnostically active substance into an aqueous medium by erosion of at least one surface of the composition, the composition comprising an erodible matrix composition comprising: (a) polyethylene oxide having a molecular weight (MW) of 200,000 daltons, (b) an active substance, and optionally, (c) one or more pharmaceutically acceptable excipients, with the proviso that the matrix composition does not contain a water dispersible or water soluble surface active agent that has at least one domain, which is compatible with the polymer in the matrix composition and at least one other domain which is lipophilic, and which has a melting point that is lower than the polymer in the matrix, and wherein the matrix is provided with a single coating having two openings exposing at least one surface of said matrix, the coating being insoluble in and impermeable to fluids and comprising either: wherein any matrix surface exposed to the aqueous medium erodes at a substantially constant rate, so that a zero order release is obtained of at least about 60% w/w of the active substance from the pharmaceutical composition when subject to an in vitro dissolution test according to USP 24, NF 19, 711 Dissolution, employing Apparatus 2 equipped with a paddle, the composition having a cylindrical shape optionally with one or more tapered ends.