Patent ID: 6903096
Filing Date: 2005-06-07
Classification: A61K,A61P,C07D

Abstract:
1. A method to inhibit p38α activity, which method comprises contacting said p38α with a compound of the formula: or the pharmaceutically acceptable salts thereof wherein R wherein Z Z each R (i) independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, acyl, wherein each of alkyl, alkenyl, alkynyl and acyl may optionally contain 1-2 O, S or N, aryl, and arylalkyl, each of said aryl and arylalkyl optionally containing 1 or more O, S or N and wherein in each of the foregoing other than H may be unsubstituted or substituted with 1-3 substituents selected independently from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkylayl, aroyl, N-aryl, NH-alkylaryl, NH-aroyl, halo, OR. NR (ii) independently selected from the group consisting of halo, OR, NR wherein L is R n is 0 or 1; and (a) Ar′ is phenyl, substituted with at least one group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR R (b) Ar′ is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR R (c) Ar′ is phenyl substituted with a group selected from the group consisting of optionally substituted NR R (d) Ar′ is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR R