Patent ID: 6541638
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is hydrogen, alkylcarbonyl, or arylcarbonyl; R2 is alkyl, alkylcycloalkyl, alkylcycloalkylalkyl, cycloalkyl, halogenalkyl, carboxyalkyl, aminoalkyl, dialkylaminoalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkinyl, aryl, arylalkyl, arylalkyl(alkoxycarbonyl)alkyl, arylcarbonylalkyl, aryloxyalkyl, arylalkenyl, aryl(alkoxycarbonyl)alkyl, heteroaryl, heteroarylalkyl, heterocyclyl or hetercycylalkyl; A is â€”C(O)â€”NR5R6, wherein â€”NR5R6 together form a pyrrolindinyl or piperidinyl ring substituted with carboxy, alkyloxycarbonyl, hydroxy, alkoxycarbonylalkoxy, phenylalkyl or phenylalkoxycarbonyl; m is 0, 1, or 2; X is â€”SO2, â€”COâ€”, â€”C(O)Oâ€”, â€”SO2NHâ€”, or â€”C(O)NR13â€” wherein R13 is hydrogen, alkyl, aryl, or carboxyalkyl; or a dimeric form, or a pharmaceutically acceptable ester, or a pharmaceutically acceptable salt thereof.