Patent ID: 6235752
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR16##a pharmacettically acceptable salt thereof whereinAr is phenyl, 1- or 2-naphthyl, 2-, 3- or 4-pyridinyl, 2- or 3-thienyl, or 4- or 5-pyrimidinyl, each of which is mono-, di-, or trisubstituted with halogen, hydroxy C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkoxky, with the proviso that at least one of the positions on Ar ortho to the point of attachment to the nitrogen-containing 10-membered aromatic ring is substituted;R.sub.1 and R.sub.2 are the same of different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, NH.sub.2, NH(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.6 alkyl).sub.2, NO.sub.2, cyano, trifluoromethyl;R.sub.3 and R.sub.4 are the same or different and representC.sub.1 -C.sub.6 alkyl optionally substituted with halogen, hydroxy, or C.sub.1 -C.sub.6 alkoxy; orC.sub.1 -C.sub.6 alkylaryl, where aryl is phenyl, 2-, 3-, or 4-pyridinyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.6 alkoxy; or C.sub.1 -C.sub.6 -Y-R.sub.5, wherein Y is O, S, NH, N(C.sub.1 -C.sub.6 alkyl), and R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl.