Patent ID: 6649589
Filing Date: 2003-11-18
Classification: A61K,A61P,C07K

Abstract:
A method of treating a nerve disorder mediated by nucleus pulposus in a mammal in need of such treatment, wherein said nerve disorder mediated by nucleus pulposus is caused by the liberation of TNF-&agr; and compounds triggerd by the liberation of or presence of TNF-&agr;, comprising the step of:(A) administering a TNF-&agr; inhibitor, wherein said TNF-&agr; inhibitor is (i) a soluble cytokine receptor that blocks TNF-&agr; activity, (ii) a monoclonal antibody that blocks TNF-&agr; activity, or (iii) a tetracycline or a chemically modified tetracycline that blocks TNF-&agr; activity, to said mammal in need of such treatment thereby inhibiting TNF-&agr; and treating said disorder.