Patent ID: 7906520
Filing Date: 2011-03-15
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating or reducing pain in a mammal in need thereof, said method comprising administering to said mammal a composition comprising a compound having the formula: R R R R the N, O, or S of the R 1 /R 2 linkage forms a bond to the pyrimidinone ring and each of R 9 , R 10 , R 11 , R 12 , and R 13 is, independently, H, C 1-6 alkyl, C 6-12 aryl, heteroaryl, C 1-4 alkaryl, or C 1-4 alkheteroaryl; or R wherein the N of the R 1 /R 2 linkage forms a bond to the pyrimidinone ring, each of R 12 and R 13 is as above, and R 14 is H, SH, OR 4 , halo, NO 2 , CN, CO 2 R 7 , CONR 7 R 8 , SO 2 R 7 , SO 2 NR 7 R 8 , C 1-6 alkyl, C 6-12 aryl, heteroaryl, C 1-4 alkaryl, or C 1-4 alkheteroaryl, wherein each of R 4 , R 7 and R 8 is, independently, H, C 1 -C 6 alkyl, C 6 -C 12 aryl, C 1 -C 4 alkaryl, heteroaryl, or C 1 -C 4 alkheteroaryl; or R wherein the N of the R 1 /R 2 linkage forms a bond to the pyrimidinone ring, each of R 9 , R 10 , R 11 , and R 14 are as above, R 3 does not exist, and a double bond is formed between the carbon bearing R 14 and the nitrogen bearing R 2 , in an amount sufficient to result in a reduction of BH4 biological activity and thereby treat or reduce pain.