Patent ID: 6395919
Filing Date: 2002-05-28
Classification: A61P,C07C,C07D

Abstract:
A compound according to Formula (I) hereinbelow: wherein:Y1 is a covalent bond, alkylene or alkenylene of up to 4 carbon atoms, unsubstituted or substituted by C1-4 alkyl, or O; Y2 is methylene, unsubstituted or substituted by C1-4 alkyl or haloalkyl; Y3 is covalent bond or O; R3 and R4 are, independently, methyl or ethyl, or, together, form cyclopropyl; R5 is aryl or fused aryl, dihydro or tetrahydro fused aryl, unsubstituted or substituted with any substituents being selected from the group consisting of OH, halogen, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, OSO2RIV, NO2, OCF3, CF3, CH2CF3, (CH2)nCO2RIV, and Oâ€”(CH2)nCO2RIV, wherein n is an integer from 0 to 3 and RIV is selected from the group consisting of H, C1-4 alkyl, and C3-6 cycloalkyl; G is a covalent bond, CHR6, CH, COH, or C&boxH;O; R7 is H, OH, or Oâ€”C1-4 alkyl; R8 is H or C14 alkyl; or R7 and R8 together form a ketone; A and B are, independently, selected from the group consisting of a bond, CH2, NH, O, S and C&boxH;O, provided that either A or B is selected from CH2 and NH; or A and B together form a bond; or the A-B moiety is represented by CH&boxH;CH or Câ‰¡C; wherein X1 and X5 are independently selected from the group consisting of H, halogen, NO2, C1-4 alkyl, cycloalkcyl, CH2-aryl, and CH2-heteroaryl; provided that either X1 or X5 is H; X2, X3 and X4 are selected from the group consisting of H, halogen, Oâ€”C1-4 alkyl, O-aryl, CH2-aryl, alkyl, C(O)aryl, CH(OH)aryl, and Jâ€”K; J is a covalent bond alkylene, O-alkylene or alkenylene of up to 5 carbon atoms, unsubstituted or substituted by a substituent selected from the group consisting of C1-4 alkyl, OH, O(forming a ketone), aryl, heteroaryl, and NRâ€²Râ€³, wherein Râ€² and Râ€³ are independently selected from the group consisting H, alkyl, aryl, heteroaryl, C(O)alkyl, C(O)aryl, and C(O)heteroaryl; K is selected from the group consisting of, CO2RIV, OH, and CN; and a pharmaceutically acceptable salt or complex thereof.