Patent ID: 6287592
Filing Date: 2001-09-11
Classification: A61K,A61P

Abstract:
A solid ibuprofen composition which, on the addition of water, is capable of yielding an aqueous preparation, said composition consisting essentially of(a) one or more medicaments including an ibuprofen medicament which forms an ibuprofen active ingredient having a melting point less than 100.degree. C. when combined with water to give an aqueous preparation having a pH of less than 7,(b) a phospholipid material intimately mixed with the ibuprofen medicament and in a ratio to said ibuprofen medicament of 0.001:1 to 0.5:1 parts by weight;(c) an acidic component in a ratio to said ibuprofen medicament of 1:20 to 20:1 parts by weight; and(d) a water-soluble carrier component;wherein, on the addition of water, said composition yields an aqueous preparation having a pH of less than 7; andsaid phospholipid material is capable of forming an aqueous preparation comprisingi) an aqueous phase substantially free of said ibuprofen active ingredient; andii) a discrete phase consisting essentially of said phospholipid material and insoluble pharmacologically active ingredient including said ibuprofen active ingredient.