Patent ID: 6482832
Filing Date: 2002-11-19
Classification: A61P,C07D

Abstract:
A compound of formula I or a tautomeric or isomeric form, an enantiomeric or diastereomeric form, or a physiologically tolerated salt thereof, whereinA denotes a fused ring â€ƒB is pyridyl; R1 is hydrogen, C1-C6-alkyl which is branched or unbranched, Oâ€”C1-C6-alkyl which is branched or unbranched, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkylphenyl, C2-C6-alkenylphenyl, C2-C6-alkynylphenyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, NHCOâ€”C1-C4-alkyl, NHCO-phenyl, CONHR11, NHSO2â€”C1-C4-alkyl, NHSO2-phenyl, SO2â€”C1-C4-alkyl or SO2-phenyl; R2 is C1-C6-alkyl which is branched or unbranched and which can additionally carry a phenyl, cyclohexyl, pyridyl, thienyl, indolyl or naphthyl ring which, for its part, is substituted by a maximum of two R1 radicals; R3 is COOR5 and CO-Z, in which R4 is hydrogen or (CH2)mNR8R9, O(CH2)mNR8R9 or R5 is C1-C6-alkyl which is straight-chain or branched and which can be substituted by a phenyl ring which can itself be additionally substituted by one or two R10 radicals; R6 is hydrogen or C1-C6-alkyl which is branched or unbranched; R7 is hydrogen or C1-C6-alkyl which is branched or unbranched and which can additionally be substituted by a phenyl or pyridine ring, which can additionally carry an R10 radical, or by R8 is C1-C6-alkyl which is straight-chain or branched and which can be substituted by a phenyl ring which can itself be additionally substituted by one or two R10 radicals; R9 is C1-C6-alkyl which is straight-chain or branched and which can be substituted by a phenyl ring which can itself be additionally substituted by one or two R10 radicals; R10 is hydrogen, C1-C4-alkyl which is branched or unbranched, â€”Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, CONH2, COOH, COOâ€”C1-C4-alkyl, â€”NHCOâ€”C1-C4-alkyl, â€”NHCO-phenyl, â€”NHSO2â€”C1-C4-alkyl, â€”NHSO2-phenyl, â€”SO2â€”C1-C4-alkyl or â€”SO2-phenyl; R11 is hydrogen, C1-C6-alkyl which is branched or unbranched; R15 is hydrogen or has the meaning of R8; m is a number 1, 2, 3, 4, 5 or 6, and n is a number 0, 1 or 2, and o is a number 0, 1, 2, 3 or 4.