Patent ID: 6790850
Filing Date: 2004-09-14
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in whichR1 represents a C3-C7 carbocyclic, C1-C8 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group, each of the groups being optionally substituted by one or more substituent groups independently selected from halogen atoms, â€”OR4, â€”NR5R6, â€”CONR5R6, â€”COOR7, â€”NR8COR9, â€”SR10, â€”SO2R10, â€”SO2NR5R6, â€”NR8SO2R9 or an aryl or heteroaryl group, both of which may be optionally substituted by one or more substituents independently selected from halogen atoms, cyano, nitro, â€”OR4, â€”NR5R6, â€”CONR5R6, â€”COOR7, â€”NR8COR9, â€”SR10, â€”SO2R10, â€”SO2NR5R6, â€”NR8SO2R9, C1-C6 alkyl or trifluoromethyl groups; R2 and R3 each independently represent a hydrogen atom, or a C3-C7 carbocyclic, C1-C8 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group, the latter four groups may be optionally substituted by one or more substituent groups independently selected from: (a) halogen atoms, â€”OR4, â€”NR5R6, â€”CONR5R6, â€”COOR7, â€”NR8COR9, â€”SR10, â€”SO2R10, â€”SO2NR5R6, â€”NR8SO2R9 (b) a 3-8 membered ring optionally containing one or more atoms selected from O, S, NR8 and itself optionally substituted by C1-C3-alkyl or halogen, (c) an aryl group or heteroaryl group each of which may be optionally substituted by one or more substituents independently selected from halogen atoms, cyano, nitro, â€”OR4, â€”NR5R6, â€”CONR5R6, â€”NR8COR9, â€”SO2NR5R6, â€”NR8SO2R9, C1-C6 alkyl and trifluoromethyl groups; R4 represents hydrogen, C1-C6 alkyl or a phenyl group the latter two of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, â€”OR11 and â€”NR12R13 R5 and R6 independently represent a hydrogen atom or a C1-C6 alkyl or phenyl group the latter two of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, â€”OR14 and â€”NR15R16, â€”CONR15R16, â€”NR15COR16, â€”SONR15R16, NR15SO2R16 or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system optionally containing a further heteroatom selected from oxygen and nitrogen atoms, which ring system may be optionally substituted by one or more substituent groups independently selected from phenyl, â€”OR14, â€”COOR14, â€”NR15R16, â€”CONR15R16, â€”NR15COR16, â€”SONR15R16, NR15SO2R16 or C1-C6 alkyl, itself optionally substituted by one or more substituents independently selected from halogen atoms and â€”NR15R16 and â€”OR17 groups; R10 represents a hydrogen atom or a C1-C6-alkyl or a phenyl group, the latter two of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, â€”OR17 and â€”NR15R16; and each of R7, R8, R9, R11, R12, R13, R14, R15, R16, R17 independently represents a hydrogen atom or a C1-C6, alkyl, or a phenyl group.