Patent ID: 8012463
Filing Date: 2011-09-06
Classification: A61K,A61P,C07F,C08G,Y02P

Abstract:
1. A coordinate complex in the form of a polymer micelle, said polymer micelle encapsulating a complex of diaminocyclohexane platinum (II) and a block copolymer comprising a structure of the general formula (A): wherein PEG represents a poly(ethylene glycol) chain segment and poly(carbo) represents a polymer chain segment having a carboxyl group and selected from the group consisting of poly(glutamic acid) chain segment and poly(aspartic acid) chain segment; wherein diaminocyclohexane platinum (II) is immobilized with the block copolymer via bonding between carboxyl anion of poly(carbo) and the platinum and wherein copolymer is represented by the following general formula (1) or (2), or a salt thereof: wherein R L L R R t-butyl oxycarbonyl group, an acetyl group, a trifluoroacetyl group, a benzyl carbonyl group, a benzhydryl carbonyl group, an acryloyl group and methacryloyl group; R R m represents an integer of 5 to 20,000; n represents an integer of 2 to 5,000; and x represents an integer of 0 to 5,000, with the proviso that x is not larger than n, and that hydrogen atoms or alkali metal ions account for 50% or more of R