Patent ID: 8828977
Filing Date: 2014-09-09
Classification: A61K,A61P

Abstract:
1. A method for slowing progression of a degenerative disc disease in a human subject suffering from the degenerative disc disease which comprises administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a 4-dedimethyltetracycline homolog or analog, in conjunction with a surgical procedure which results in the intervertebral discs of the subject being accessible to the 4-dedimethyltetracycline homolog or analog, wherein said pharmaceutical composition is administered in an amount effective to slow the progression of the degenerative disc disease, wherein the surgical procedure comprises microdiscectomy, and wherein said 4-dedimethyltetracycline homolog or analog is selected from the group consisting of 4-dedimethylaminotetracycline, 4-dedimethylaminosancycline (6-demethyl-6-deoxy-4-dedimethylaminotetracycline), 4-dedimethylaminominocycline (7-dimethylamino-4-dedimethylaminotetracycline), and 4-dedimethylaminodoxycycline (5-hydroxy-6-deoxy-4-dedimethylaminotetracycline); is present in said pharmaceutical composition at a concentration of 0.1% to 5% by weight of the composition; and is administered in an amount between 0.1 mg/kg and 30 mg/kg body weight of the subject.