Patent ID: 7465542
Filing Date: 2008-12-16
Classification: C12Q

Abstract:
1. A method of determining the suitability of a patient for radiation therapy, the method comprising: predicting whether a subject will be susceptible to undesirable toxicity resulting from treatment with radiation therapy, said method comprising: (a) obtaining transcriptional expression profile for the response to radiation for a sample from said subject from a set of sequences comprising: Cyclin B, ATP synthase, CDC28, protein kinase 2, forming-binding protein 17, ribosomal protein 17, ribosomal protein S9, phorbolin-like protein MDS019, tumor necrosis factor superfamily member 7, RNA helicase disrupter of silencing 10, heat shock 27 kD protein 1 (b) comparing said obtained expression profile to a reference expression profile from a cell known to have a susceptible phenotype for radiation toxicity to determine the probability that said patient is susceptible to undesirable radiation toxicity; wherein a patient that is predicted to have a high probability of undesirable radiation toxicity is less suitable for radiation therapy.