Patent ID: 7749961
Filing Date: 2010-07-06
Classification: A61K,A61P,C07K

Abstract:
1. A compound of formula (I): wherein R 1 is NHSO 2 R 11 wherein R 11 is (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl-(C 1-6 )alkyl-, aryl, Het, aryl-(C 1-4 )alkyl-, or Het-(C 1-4 )alkyl-; a) said (C b) said (C R  R R  R  R  R  R or R 2 is a group of formula:  R  R  R X is O or NH; R  a) wherein the cycloalkyl and cycloalkyl-alkyl- may be mono-, di- or tri-substituted with (C  b) wherein the alkyl, cycloalkyl and cycloalkyl-alkyl- may be mono- or di-substituted with substituents each independently selected from hydroxy and O—(C  c) wherein each alkyl group may be mono-, di- or tri-substituted with halogen; and  d) wherein in each cycloalkyl group being 5-, 6- or 7-membered, one or two —CH D is a 3 to 8 atom saturated or unsaturated alkylene chain; and the dotted line “b” is a single bond or a double bond; wherein Het as used herein is defined as a 3- to 7-membered heterocycle having 1 to 4 heteroatoms each independently selected from O, N and S, which may be saturated, unsaturated or aromatic, and which is optionally fused to at least one other cycle to form a 4- to 14-membered heteropolycycle having wherever possible 1 to 5 heteroatoms, each independently selected from O, N and S, said heteropolycycle being saturated, unsaturated or aromatic; or a pharmaceutically acceptable salt or ester thereof; with the proviso that when R 2 is a group of formula W is N; and the dotted line “a” is a double bond; and R R R R then R 1 is not NHSO 2 R 11 wherein R 11 is (C 1-6 )alkyl or unsubstituted (C 3-7 )cycloalkyl.