Patent ID: 7186545
Filing Date: 2007-03-06
Classification: A23L,A23Y,A61K,A61P,C07K,C12N,C12R

Abstract:
1. A biologically pure culture of a strain of Lactobacillus salivarius which is adherent to Caco-2 and HT-29 cells, and is isolated from resected and washed human gastrointestinal tract, wherein said strain of Lactobacillus salivarius has the following properties: a) binds to human epithelial cells and inhibits a broad range of Gram positive and Gram negative microorganisms; b) secretes a product having antimicrobial activity into a cell-free supernatant, wherein said product having antimicrobial activity is produced only by growing cells and wherein said antimicrobial activity is destroyed by proteinase K and pronase E; and c) maintains the properties of inhibiting said Gram positive and Gram negative microorganisms, and secreting said product having antimicrobial activity, in the presence of physiological concentrations of human bile and human gastric juice.