Patent ID: 8987197
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K

Abstract:
1. A PEGylated analogue of human insulin, wherein the amino acid in position A14 is Glu (A14E), the amino acid in position B25 is H is (B25H), comprising the desB30 mutation, and wherein the PEG moiety comprises the moiety —(OCH 2 CH 2 ) n —, wherein n is an integer in the range from 2 to about 500, that via a linker is attached to the ε amino acid in the lysine residue in position B29 (B29K), wherein said linker is a —CO— group, or is derived from an acetic acid moiety with the linking motif —CH 2 CO—, or a propionic acid with the linking motif —CH 2 CH 2 CO— or —CHCH 3 CO—, or from a butyric acid moiety with the linking motif —CH 2 CH 2 CH 2 CO— or —CH 2 CHCH 3 CO—; and wherein the PEGylated analogue of human insulin has improved stability towards proteolytic degradation at protease cleavage sites.