Patent ID: 8697133
Filing Date: 2014-04-15
Classification: A61K

Abstract:
1. A method of preparing bioactive molecule coated microcrystals which display a delayed and/or prolonged release profile of said bioactive molecule in water and/or aqueous solution, comprising the steps of: providing an organic solution comprising a precipitated water-soluble inorganic first metal salt, one or more precipitated bioactive molecules, a precipitated material capable of forming said microcrystals, and a dissolved second metal salt, carrying out a double decomposition reaction in said organic solution between the water soluble inorganic first metal salt and the dissolved second metal salt to form bioactive molecule coated microcrystals comprising a coating of a third metal salt, and wherein the third metal salt, formed by the double decomposition reaction, is present on the surface of the microcrystals, and wherein the microcrystals are water soluble/aqueous solution-soluble microcrystals.