Patent ID: 6103738
Filing Date: 2000-08-15
Classification: A61P,C07D

Abstract:
A compound of formula I, ##STR31## wherein R.sup.1 represents C.sub.1-4 alkoxy optionally substituted by one or more fluorine atoms;R.sup.2 represents H or C.sub.1-6 alkoxy optionally substituted by one or more fluorine atoms;R.sup.3 represents one or more groups independently selected from H, halogen, C.sub.1-4 alkoxy and CF.sub.3 ;in addition, R.sup.2 and one R.sup.3 group may together represent --OCH.sub.2 --, the methylene group being attached to the ortho-position of the pendant phenyl ring;R.sup.4 represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, 0 and S, the ring system as a whole being optionally substituted by one or more groups independently selected from OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, SO.sub.2 NR.sup.8 R.sup.9 and NHSO.sub.2 (C.sub.1-4 alkyl), and when S is a member of the ring system, it may be substituted by one or two oxygen atoms;R.sup.8 and R.sup.9 independently represent H or C.sub.1-4 alkyl;X represents CH; andL is absent,or represents a cyclic group of formula Ia, ##STR32## in which N is attached to the 2-position of the quinoline or quinazoline ring;A is absent or represents CO or SO.sub.2 ;Z represents CH or N;m represents 1 or 2, and in addition, when Z represents CH, it may represent 0; andn represents 1, 2 or 3, provided that the sum of m and n is 2, 3, 4 or 5;or represents a chain of formula Ib, ##STR33## in which N is attached to the 2-position of the quinoline or quinazoline ring;A' and Z' have the same significance as A and Z above, respectively;R.sup.6 and R.sup.7 independently represent H or C.sub.1-4 alkyl; andp represents 1, 2 or 3, and in addition, when Z' represents CH, it may represent 0;or a pharmaceutically acceptable salt thereof.