Patent ID: 6982275
Filing Date: 2006-01-03
Classification: A61K,A61P,C07D

Abstract:
1. A method for producing an optically active form of a compound represented by the formula (II): wherein ring A is a benzene ring optionally having 1 to 3 substituent(s) selected from (a) a halogen atom, (b) a cyano, (c) a nitro, (d) an alkyl optionally having 1 to 3 substituent(s) selected from a halogen atom, a hydroxy, a C R R X is a nitrogen atom or CH, Y is a nitrogen atom or CH, and * is an asymmetric center, or a salt thereof, comprising reacting a compound represented by the formula (I): with an excess amount of an oxidizing agent in the presence of a catalyst for asymmetric induction and a base; wherein the amount of the oxidizing agent to be used is about 1.5 to about 10 molar equivalents relative to the compound represented by the formula (I) or a salt thereof.