Patent ID: 7812133
Filing Date: 2010-10-12
Classification: A61K,A61P,C07K

Abstract:
1. An isolated anti-OX40L antibody comprising: (a) a light chain comprising (i) HVR-L1 comprising sequence RSSQSIVHGNGNTYLE (SEQ ID NO: 1) or RSSQSPVHSNGNTYLH (SEQ ID NO:2); (ii) HVR-L2 comprising sequence RVSNRFS (SEQ ID NO:3) or KVSNRFS (SEQ ID NO:4); and (iii) HVR-L3 comprising sequence FQGSHVPYT (SEQ ID NO:5) or SQSTHIPWT (SEQ ID NO:6); and (b) a heavy chain comprising (i) HVR-H1 comprising sequence SYWLN (SEQ ID NO:7) or SYWMH (SEQ ID NO:8); (ii) HVR-H2 comprising sequence MIDPSDSETHYNQVFKD (SEQ ID NO:9) or EIDPSNGRTNYNEKFKS (SEQ ID NO: 10); and (iii) HVR-H3 comprising sequence GRGNFYGGSHAMEY (SEQ ID NO: 11) or ERSPRYFDV (SEQ ID NO: 12), wherein the anti-OX40L antibody binds OX40L.