Patent ID: 6726928
Filing Date: 2004-04-27
Classification: A61K

Abstract:
A process for the preparation of a solid, oral, rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste, which process comprises:a) forming a system selected from the group consisting of a solution and a suspension in an aqueous or alcoholic solvent of a form of the pharmaceutically active substance which is rendered less soluble by a method selected from the group consisting of conversion of a salt to a corresponding free acid, conversion of a salt to a corresponding free base, changing the salt form, formation of a hydrate and changing the polymorphic form thereof; together with a carrier material selected from the group consisting of water-soluble and water-dispersible carrier materials; b) forming discrete units of the system; and c) removing the solvent from the discrete units under conditions whereby a network of the carrier material carrying a dosage of the less soluble and more palatable form of the pharmaceutically active substance is formed.