Patent ID: 9102708
Filing Date: 2015-08-11
Classification: C07B,C07C,C07K

Abstract:
1. A method for the synthesis of an organic compound with at least two dicarba bridge, comprising: providing a reactable organic compound comprising a peptide comprising a series of amino acids, wherein two of the amino acids comprise side chains having a first pair of unblocked complementary metathesisable groups and another two of the amino acids comprise side chains having a second pair of complementary metathesisable groups which are blocked and can be unblocked by an unblocking reaction specific to the second pair of complementary metathesisable groups, wherein the peptide contains at least one ψproline between the amino acids that comprise the first pair of complementary metathesisable groups, and the ψproline is selected from the group consisting of ψserine, ψthreonine and ψcysteine, and subjecting the reactable organic compound to cross-metathesis under microwave radiation conditions to form an organic compound with a first unsaturated dicarba bridge; and subjecting the second pair of complementary metathesisable groups to an unblocking reaction or reactions specific to the second pair, followed by cross-metathesis of the second pair of cross-methatesisable groups to form an organic compound with a second unsaturated dicarba bridge.