Patent ID: 6380447
Filing Date: 2002-04-30
Classification: C07D

Abstract:
A method of making a bicyclic compound selected from the group consisting of compounds of Formula X and compounds of Formula XI: wherein:R, R1, R2, R3, and R4 are each independently selected from the group consisting of H, and C1-C4 lower alkyl; and R11 and R12 each independently represent â€”H, â€”OH, â€”OCOCH3, â€”OCH2C6H5, or â€”OR13 wherein R13 represents C1-C4 lower alkyl, or R11 and R12 together represent â€”Oâ€”, â€”Oâ€”C(O)â€”Oâ€” or â€”Oâ€”C(CH3)2â€”Oâ€”; comprising reacting a diene according to Formula I: wherein R, R1, R2, R3, and R4 are as given above with a dieneophile according to Formula VI: wherein R11 and R12 are as given above, in a Diels-Alder reaction at a pressure greater than atmospheric pressure to yield a compound selected from the group consisting of compounds of Formula X and compounds of Formula XI.