Patent ID: 6060067
Filing Date: 2000-05-09
Classification: A61K,A61P

Abstract:
A process for the preparation of tetanus toxoid, which process consists essentially of incubating purified tetanus toxin having a specific activity of 2000 Lf/mg PN (Limes flocculationis/mg protein nitrogen) or more and an Lf content of 250 Lf/ml or more with 0.2 to 1% (V/V) formaldehyde in the presence of 0.005 to 0.25M lysine for from 24 to 32 days at a pH of from 6.0 to 8.0 and a temperature of from 30 to 45.degree. C. wherein the toxoid does not revert to toxin when stored at 37.degree. C. for 3 months.