Patent ID: 7790899
Filing Date: 2010-09-07
Classification: A61P,C07D

Abstract:
1. A method of synthesizing N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide, comprising: reacting 4-hydroxybenzaldehyde with isobutylbromide in the presence of dimethylformamide, potassium iodide and potassium carbonate to produce 4-isobutoxybenzaldehyde; reacting the 4-isobutoxybenzaldehyde with about 1.5 equivalents of NH reacting the 4-isobutoxybenzoxime with H adding acetic acid to produce (4-isobutoxyphenyl)methanamine acetate; treating the (4-isobutoxyphenyl)methanamine acetate with about 30% NaOH and extracting with toluene to produce (4-isobutoxyphenyl)methanamine; reacting the (4-isobutoxyphenyl)methanamine with HCl and COCl reacting a solution of the 1-isobutoxy-4-(isocyanatomethyl)benzene in toluene with N-(4-fluorobenzyl)-1-methylpiperidin-4-amine to produce N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide.