Patent ID: 6686496
Filing Date: 2004-02-03
Classification: C07C

Abstract:
A derivative of a 4-oxo-2-butenoic acid having the property of anti-myeloma activity, wherein said derivative is selected from the group consisting of:4-(4-Chloro-phenyl)-2-(Nâ€²-fluoren-9-ylidene-hydrazino)-4-oxo-but-2-enoic acid methyl ester: 2-{Nâ€²-[(2-Bromo-phenyl)-phenyl-methylene]-hydrazino}-4-oxo-4-phenyl-but-enoic acid methyl ester; 2-{Nâ€²-[(4-Dimethylamino-phenyl)-phenyl-methylene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester; and -2-{Nâ€²-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester.