Patent ID: 6747159
Filing Date: 2004-06-08
Classification: C09B,G01N

Abstract:
A symmetric cyanine of the formula: wherein:X is C(CH3)2; W represents non-metal atoms required to form a benzo-condensed or a naphto-condensed ring; R1 is selected from the group consisting of(CH2)nCH3, (CH2)nSO3âˆ’ and (CH2)nSO3H, wherein n is an integer selected from 0 to 6 when R1 is (CH2)nCH3, and n is an integer selected from 3 to 6 when R1 is (CH2)nSO331  or (CH2)nSO3H; R2 and R3 are independently selected from the group consisting of H, a sulphonic moiety and a sulphonate moiety; Q is selected from the group consisting of: â€ƒwherein q is 0 or 1 and D is selected from the group consisting of: â€ƒwherein G is a nucleophile moiety selected from the group consisting of (CH2)mNH2, (CH2)mSH, (CH2)mY(CH2)pOH, (CH2)mY(CH2)pNH2 and (CH2)mY(CH2)pSH, wherein Y is selected from the group consisting of â€”NHâ€”, â€”CONHâ€”, â€”Oâ€” and â€”Sâ€”, m is an integer selected from 0 to 6 and p is an integer selected from 1 to 6; or wherein G is a moiety capable of reacting with N, O or S nucleophiles, and is selected from the group consisting of (CH2)mCOOH, (CH2)mglycidyl, (CH2)mmaleimide, (CH2)mCOâ€”NHS, (CH2)mCO-imidazole, (CH2)mSO2CH&boxH;CH2, (CH2)mCONHNH2, (CH2)mCHO, (CH2)mY(CH2)pCOOH, (CH2)mY(CH2)pglycidyl, (CH2)mY(CH2)pmaleimide, (CH2)mY(CH2)pCOâ€”NHS, (CH2)mY(CH2)pCO-imidazole, CH2(CH2)mOâ€”PAM, (CH2)mY(CH2)pSO2CH&boxH;CH2, (CH2)mY(CH2)pCONHNH2, (CH2)mY(CH2)pCHO and (CH2)mY(CH2)pOâ€”PAM, wherein Y, m and p have the meanings indicated above.