Patent ID: 7789907
Filing Date: 2010-09-07
Classification: A61F,A61L,Y10T

Abstract:
1. A radially expandable prosthesis for implantation in a lumen, the prosthesis comprising: a tubular wall having an inner surface and an outer surface, the tubular wall provided with cuts forming solid struts having a predetermined thickness and enabling the prosthesis to expand, said solid struts having a longitudinal direction and having reservoirs made in said outer surface for containing a therapeutic agent, wherein at least a number of said reservoirs are perforating holes over the entire thickness of the strut through the strut to form an outer opening at the outer surface of the tubular wall and an inner opening at the inner surface of the tubular wall, said inner opening having a first size and said outer opening having a second size, each perforating hole having a width extending through the entire thickness, the width being no greater than at least one of the first size and the second size, wherein said inner opening and said outer opening each comprise a width measured perpendicularly to said longitudinal direction of said strut, and a length, measured in said longitudinal direction, at most five times said width, the prosthesis, including said perforating holes, having a smooth electrochemically polished surface; at least one polymer layer; and an effective amount of at least one therapeutic agent wherein the at least one therapeutic agent is provided in a releasable combination with the at least one polymer layer, wherein the releasable combination comprises a plurality of layers including at least one barrier layer, wherein said therapeutic agent is contained in said perforating holes.