Patent ID: 7776522
Filing Date: 2010-08-17
Classification: G01N

Abstract:
1. A method for diagnosing human papillomavirus (HPV) infection in a subject comprising: a) generating a peptide fingerprinting pattern by peptide mass fingerprinting (PMF) for at least one target protein in a biological sample from the subject; and b) determining the presence or absence of at least one biomarker associated with HPV infection in the biological sample by correlating the peptide fingerprinting pattern of the target protein with a known peptide fingerprinting pattern of at least one biomarker associated with HPV infection; wherein the at least one biomarker is a protein encoded by the E2, E5, E6, E7, or E8 regions of oncogenic forms of HPV; whereby a match of the peptide fingerprinting pattern of the target protein with the known peptide fingerprinting pattern indicates the presence of at least one biomarker in the sample; whereby the presence of the at least one biomarker associated with HPV infection in the biological sample indicates HPV infection in the subject.