Patent ID: 6268525
Filing Date: 2001-07-31
Classification: C07C,Y02P

Abstract:
A method for producing an optically active chrysanthemic acid having improved trans isomer ratio and optical purity, comprising the step of reacting chrysanthemic acid having a trans isomer ratio of not less than 50% and an optical purity of not less than 10% e.e. with an optically active amine to optically resolve said chrysanthemic acid, wherein said optically active amine is an optically active amine of formula (A-1) ##STR8##wherein R.sub.1 and R.sub.2 respectively represent a hydrogen atom, an alkyl group, an aralkyl group or an aryl group,X and Y respectively represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxyl group, and* represents an asymmetric carbon atom; oran optically active amine of formula (A-2): ##STR9##wherein R.sub.1 and R.sub.2 respectively represent a hydrogen atom, an alkyl group, an aralkyl group or an aryl group,R.sub.3 represents an alkyl group having 1 to 6 carbon atoms, and* represents an asymmetric carbon atom; oran optically active organic amine of formula (A-3): ##STR10##wherein R.sub.4 represents a naphthyl group, a cyclohexyl group, or a phenyl group which may be substituted with halogen, nitro, lower alkyl or lower alkoxy,R.sub.5 represents a lower alkyl group, or a benzyl group which may be substituted with a lower alkyl group,R.sub.6 represents a p-hydroxyphenyl group or a 2-hydroxy-3-lower alkoxyphenyl group when R.sub.5 is a lower alkyl group, andR.sub.6 represents a p-hydroxyphenyl group when R.sub.5 is a benzyl group which may be substituted with a lower alkyl group, and* represents an asymmetric carbon atom; oran optically active organic amine of formula (A-4): ##STR11##wherein R.sub.1 and R.sub.2 respectively represent a hydrogen atom, an alkyl group, an aralkyl group or an aryl group, and* represents an asymmetric carbon atom.