Patent ID: 9155704
Filing Date: 2015-10-13
Classification: A61K,G01N

Abstract:
1. A pharmaceutical composition of a palatable tablet comprising the pharmaceutically active ingredient carprofen and at least two excipients, whereby the amount of carprofen is about 13.97% of the total weight of said palatable tablet, and whereby at least one excipient of said at least two excipients comprises at least one flavoring agent; said at least one flavoring agent having a meat-like taste; said at least one flavoring agent having a meat-like odor; said at least one flavoring agent further able to at least partially mask the taste of said pharmaceutically active ingredient carprofen; said palatable tablet structured to contain a combined weight of one or more flavoring agents of no more than about 5% of the total weight of said palatable tablet; said palatable tablet further having an in vitro dissolution profile specifically determined by use of a Peak vessel/Peak flask during in vitro dissolution testing as part of an analytical method; said palatable tablet further having an in vitro dissolution profile and bioequivalence nearly identical to less palatable carprofen tablet or caplet compositions, including compositions not containing a flavoring agent; said palatable tablet further structured to be non-coated; said palatable tablet further being deliverable by oral administration; said palatable table further being structured to be non-chewable; said palatable tablet further structured to be easily swallowed for oral administration without chewing; said palatable tablet associated with an at least a 90% voluntary acceptance rate when consumed voluntarily; said palatable tablet further being able to relieve clinical symptoms of pain and inflammation associated with osteoarthritis and postoperative veterinary surgery in mammals, including canines, when swallowed, by inhibiting prostaglandin formation by inhibiting cyclooxygenase-2; said palatable tablet further comprising filler excipient(s) with a combined weight of 72.00% of the total weight of said palatable tablet; disintegrant excipient(s) with a combined weight of 4.97% of the total weight of said palatable tablet, coloring agent excipient(s) with a combined weight of 0.08% of the total weight of said palatable tablet, and lubricant excipient(s) with a combined weight of 3.98% of the total weight of said palatable tablet.