Patent ID: 9119829
Filing Date: 2015-09-01
Classification: A61K,A61P

Abstract:
1. A method for generating a solution rich in interleukin-1 receptor antagonist comprising: (a) contacting a liquid comprising white blood cells with a solid extraction material, wherein the solid extraction material activates the white blood cells to generate interleukin-1 receptor antagonist, and wherein the solid extraction material comprises a member selected from the group consisting of corundum, quartz, titanium, dextran, agarose, polystyrene, polyethylene, polyvinyl chloride, polypropylene, and combinations thereof; (b) subjecting the liquid to an electromagnetic field wherein the electromagnetic field comprises a pulsed electromagnetic field or a capacitively coupled electromagnetic field; and (c) separating the liquid from the solid extraction material to obtain a solution rich in interleukin-1 receptor antagonist, wherein the concentration of interleukin-1 receptor antagonist in the solution is greater than the concentration of interleukin-1 receptor antagonist in the liquid prior to contacting the liquid with the solid extraction material.