Patent ID: 7312030
Filing Date: 2007-12-25
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for increasing the capability of an Arterivirus to replicate in a permissive cell, said method comprising: determining amino acids of the Arterivirus at positions that correspond to amino acid positions 75-107 of GP2a (SEQ. ID. NO. 6) of PRRSV isolate I-1102; and changing at least one of the determined amino acids of the Arterivirus to a different amino acid, wherein at least one of the determined amino acids of the Arterivirus corresponds to position 88 of GP2a of PRRSV isolate I-1102, and wherein the determined amino acid of the Arterivirus that corresponds to position 88 of GP2a of PRRV isolate I-1102 is changed from a valine to another amino acid.