Patent ID: 6130337
Filing Date: 2000-10-10
Classification: C07C,C07D

Abstract:
A method for preparing enantiomerically enriched compounds comprising:alkylating an allylic electrophile with a 5-(4H)-oxazolone of the formula ##STR18## in the presence of a base and a transition metal complex having one or more chiral ligands, wherein R.sup.1 is selected from a group consisting of hydrogen, substituted and unsubstituted C.sub.1 -C.sub.20 allyls, substituted and unsubstituted C.sub.1 -C.sub.20 aryls, and substituted and unsubstituted C.sub.1 -C.sub.20 heteroaryls, R.sup.2 is an amino acid side-chain, a substituted amino acid side-chain or is selected from a group consisting of substituted and unsubstituted C.sub.1 -C.sub.20 alkls, substituted and unsubstituted C.sub.1 -C.sub.20 aryls, and substituted and unsubstituted C.sub.1 -C.sub.20 heteroaryls, wherein the allylic electrophile is selected from ##STR19## and ##STR20## wherein n=1 to 6, R.sup.4 is selected from a group consisting of hydrogen, substituted and unsubstituted C.sub.1 -C.sub.20 alkyls, substituted and unsubstituted C.sub.1 -C.sub.20 aryls, and substituted and unsubstituted C.sub.1 -C.sub.20 heteroaryls, and L is an ionizable group, to form 4,4-disubstituted-5(4H)-oxazolones.