Patent ID: 6229025
Filing Date: 2001-05-08
Classification: A61P,C07C,C07D,Y02P

Abstract:
A compound of the formula ##STR14##wherein R.sup.1 is (C.sub.1 -C.sub.6)alkyl or optionally substituted benzyl;R.sup.2 and R.sup.3 are independently (C.sub.1 -C.sub.6)alkyl or R.sup.2 and R are taken together to form a three to seven membered cycloalkyl, pyran-4-yl ring or a bicyclo ring of the formula ##STR15##wherein the asterisk indicates the carbon atom common to R.sup.2 and R.sup.3 ;Q is (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.2 -C.sub.9)heteroaryl (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl or (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl;wherein each (C.sub.6 -C.sub.10)aryl or (C.sub.2 -C.sub.9)heteroaryl moieties of said (C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(,C.sub.6 -C.sub.10)aryl or (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl is optionally substituted on any of the ring carbon atoms capable of forming an additional bond by one or more substituents per ring independently selected from fluoro, chloro, bromo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, perfluoro(C.sub.1 -C.sub.3)alkyl, perfluoro(C.sub.1 -C.sub.3)alkoxy and (C.sub.6 -C.sub.10)aryloxy;and Y is hydrogen or (C.sub.1 -C.sub.6)alkyl.