Patent ID: 6756378
Filing Date: 2004-06-29
Classification: C07C,C07D

Abstract:
A compound represented by Formula I, or a salt thereof, whereinW is chosen from aryl group, substituted aryl group, heteroaryl group and substituted heteroaryl group; W1 is chosen from arylene group, substituted arylene group, heteroarylene group and substituted heteroarylene group; A is chosen from &boxH;O, &boxH;S and &boxH;NH; R is chosen from a direct bond, alkyenylene group and â€”(CH2)nâ€”, wherein n is chosen from 1 and 2; X is chosen from â€”C(O)â€”, â€”CH2â€” and S(O)2; M is chosen from â€ƒthe nitrogen atom is the point of attachment to X; R1, R2 and R3 are independently chosen from â€”H, â€”O, â€”NH2, halogen atom, alkyl group, substituted alkyl group, aryl group, substituted aryl group, alkoxy group, substituted alkoxy group, monoalkylamino group, substituted monoalkylamino group, dialkylamino group, substituted dialkylamino group, cycloalkylamino group, substituted cycloalkylamino group, alkylsulfonylamino group, substituted alkylsulfonylamino group, arylsulfonylamino group, substituted arylsulfonylamino group, aryloxy group, substituted aryloxy group, heteroaryloxy group, substituted heteroaryloxy group, benzyloxy group and substituted benzyloxy group, or two of R1, R2 and R3 taken together may form a 3-, 4-, 5-, 6-, or 7-membered carbocyclic or heterocyclic residues optionally substituted with from 1 to 3 substituents chosen independently from â€”OH, halogen atom, â€”NH2, alkyl group, alkoxy group, aryl group, aryloxy group, alkylamino group, benzyloxy group and heteroaryl group; R4 is chosen from â€”H and lower alkyl group; Y is a direct bond or a divalent radical chosen from â€”C(O)â€”, â€”C(O)NHâ€”, alkenylene group, alkynylene group and â€”(CH2)kY2, wherein k is chosen from 1, 2 and 3; and Y2 is a direct bond or a divalent radical chosen from â€”Oâ€”, â€”Sâ€”, â€”S(O), â€”S(O)2â€” and â€”NY3â€”, wherein Y3 is chosen from â€”H and lower alkyl group; Z is chosen from arylene group, substituted arylene group, heterocyclylene group, substituted heterocyclylene group, cycloalkylene group and substituted cycloalkylene group; with the proviso that, when Y is a direct bond, Z cannot be a 5-membered nitrogen heterocyclylene or substituted 5-membered nitrogen heterocyclylene group; A1 is a direct bond or a divalent radical chosen from alkenylene group, alkynylene group, â€”(CH2)tâ€” and â€”O(CH2)v, wherein t is chosen from 1, 2 and 3; and v is chosen from 0, 1, 2, and 3; and R5 is chosen from â€”OH, lower alkoxy group, â€”N(H)OH, â€ƒthe nitrogen atom is the point of attachment to X; R6 and R7 are independently chosen from â€”H, â€”OH, halogen atom, alkyl group and alkoxy group; Y1 is a divalent radical chosen from â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€” and â€”NY4â€”, wherein Y4 is chosen from â€”H and lower alkyl group; Z1 is a divalent radical chosen from arylene group, substituted arylene group, heterocyclylene group, substituted heterocyclylene group, cycloalkylene group and substituted cycloalkylene group; A2 is a direct bond or a divalent radical chosen from alkenylene group, alkynylene group and â€”(CH2)e wherein e is chosen from 1, 2 and 3; and R8 is chosen from â€”OH, lower alkoxy group, â€”N(H)OH, â€ƒwherein L is â€ƒwherein â€ƒis a pyrrolidine, optionally substituted with from 1 to 3 substitutents chosen independently from alkyl group, alkoxy group, hydroxyalkyl group, â€”OH, benzyloxy group, â€”NH2, halogen atom, aryl group and heteroaryl group, said moiety may be fused to 1 or 2 additional carbocyclic or heterocyclic residues optionally substituted with from 1 to 3 substitutents chosen independently from alkyl group, aryloxy group, alkoxy group, hydroxyallyl group, â€”OH, benzyloxy group, â€”NH2, halogen atom, aryl group and heteroaryl group; m and q are independently chosen from 0, 1, 2 and 3; X1 is chosen from â€”CH&boxH; and â€”N&boxH;; R9 is chosen from â€”H and lower alkyl group; R10 is chosen from â€”COOH, lower alkoxycarbonyl group, Z2 is chosen from â€”H, COOH and lower alkoxycarbonyl group; and â€ƒwherein R11 is chosen from â€ƒwherein the left hand bond is the point of attachment to â€”Xâ€” and the right hand bond is the point of attachment to â€”Z3; Z3 is chosen from a direct bond, a divalent aliphatic hydrocarbon moiety having 1 to 12 carbon atoms, wherein one or more carbon atoms may be replaced with â€”Oâ€” or â€”NR13â€”, wherein R13 is chosen from â€”H and lower alkyl group, and one or more hydrogen atoms attached to an aliphatic carbon atom may be replaced with lower alkyl group; and â€ƒwherein x is chosen from 0 and 1; y is chosen from 1, 2, and 3; and R14 is chosen from â€”H, â€”OH and halogen atom, Q2 is a divalent radical chosen from arylene group, substituted arylene group, heterocyclylene group, substituted heterocyclylene group, cycloalkylene group, substituted cycloalkylene group, â€ƒwherein R15 and R16 are independently chosen from â€”H, halogen atom and lower alkyl group; and â€ƒwherein R17 and R18 are independently chosen from â€”H, lower alkyl group, substituted lower alkyl group and lower alkenyl group; and L1 is chosen from â€”COOH and â€”COOR19 wherein R19 is a lower alkyl group.