Patent ID: 7056918
Filing Date: 2006-06-06
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein R 1 and R 2 are each independently selected from the group consisting of hydrogen, (C 1 –C 6 )alkyl, (C 3 –C 10 )cycloalkyl, phenyl, (C 1 –C 10 )heteroaryl and (C 1 –C 10 )heterocyclic; each of the aforesaid (C 1 –C 6 )alkyl, (C 3 –C 10 )cycloalkyl, phenyl, (C 1 –C 10 )heteroaryl and (C 1 –C 10 )heterocyclic substituents may optionally be independently substituted by one to four moieties independently selected from the group consisting of halo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, perhalo(C 1 –C 6 )alkyl, phenyl, (C 3 –C 10 )cycloalkyl, (C 1 –C 10 )heteroaryl, (C 1 –C 10 )heterocyclic, formyl, —CN, (C 1 –C 6 )alkyl-(C═O)—, phenyl-(C═O)—, HO—(C═O)—, (C 1 –C 6 )alkyl-O—(C═O)—, (C 1 –C 6 )alkyl-NH—(C═O)—, [(C 1 –C 6 )alkyl] 2 -N—(C═O)—, phenyl-NH—(C═O)—, phenyl-[((C 1 –C 6 )alkyl)-N]—(C═O)—, —NO 2 , amino, (C 1 –C 6 )alkylamino, [(C 1 –C 6 )alkyl] 2 -amino, (C 1 –C 6 )alkyl-(C═O)—NH—, (C 1 –C 6 )alkyl-(C═O)—[((C 1 –C 6 )alkyl)-N]—, phenyl-(C═O)—NH—, phenyl-(C═O)—[((C 1 –C 6 )alkyl)-N]—, H 2 N—(C═O)—NH—, (C 1 –C 6 )alkyl-HN—(C═O)—NH—, [(C 1 –C 6 )alkyl-] 2 N—(C═O)—NH—, (C 1 –C 6 )alkyl-HN—(C═O)—[((C 1 –C 6 )alkyl)-N]—, [(C 1 –C 6 )alkyl-] 2 N—(C═O)—[((C 1 –C 6 )alkyl)-N]—, phenyl-HN—(C═O)—NH—, (phenyl-) 2 N—(C═O)—NH—, phenyl-HN—(C═O)—[((C 1 –C 6 )alkyl)-N]—, (phenyl-) 2 N—(C═O)—[((C 1 –C 6 )alkyl)-N]—, (C 1 –C 6 )alkyl-O—(C═O)—NH—, (C 1 –C 6 )alkyl-O—(C═O)—[((C 1 –C 6 )alkyl)-N]—, phenyl-O—(C═O)—NH—, phenyl-O—(C═O)—[((C 1 –C 6 )alkyl)-N]—, (C 1 –C 6 )alkyl-SO 2 NH—, phenyl-SO 2 NH—, (C 1 –C 6 )alkyl-SO 2 —, phenyl-SO 2 —, hydroxy, (C 1 –C 6 )alkoxy, perhalo(C 1 –C 6 )alkoxy, phenoxy, (C 1 –C 6 )alkyl-(C═O)—O—, phenyl-(C═O)—O—, H 2 N—(C═O)—O—, (C 1 –C 6 )alkyl-HN—(C═O)—O—, [(C 1 –C 6 )alkyl-] 2 N—(C═O)—O—, phenyl-HN—(C═O)—O—, and (phenyl-) 2 N—(C═O)—O—; wherein two adjacent substituents on said R 1 or R 2 (C 3 –C 10 )cycloalkyl, phenyl, (C 1 –C 10 )heteroaryl, or (C 1 –C 10 )heterocyclic may be taken together with the carbon or heteroatom to which they are attached to form a five to six membered carbocyclic or heterocyclic ring; wherein each of said moieties containing a phenyl alternative may optionally be substituted by one or two radicals independently selected from the group consisting of (C 1 –C 6 )alkyl, halo, (C 1 –C 6 )alkoxy, perhalo(C 1 –C 6 )alkyl and perhalo(C 1 –C 6 )alkoxy; each R s is an integer from zero to five; R n is an integer from zero to six; each B is independently a bond, —(CHR R p is an integer from one to six; R m is an integer from one to six; R R each R R R each R each R or R with the proviso that when R or a pharmaceutically acceptable salt thereof.