Patent ID: 6310088
Filing Date: 2001-10-30
Classification: A61P,C07D

Abstract:
A compound, represented by formula (I): ##STR6##whereinn is 1-2;X is O or S(O).sub.0-2 ;Y is NHOH;W is CR.sup.3 or (when X is SO.sub.2) N;R.sup.1 is H or a substituent selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, heterocycloalkyl, C.sub.1-6 alkyl-heterocycloalkyl, cycloalkyl, and C.sub.1-6 alkyl-cycloalkyl, wherein said substituent is optionally substituted with R.sup.14, andR.sup.2 is H or C.sub.1-6 alkyl, orCR.sup.1 R.sup.2 is a cycloalkyl or heterocycloalkyl ring, optionally substituted with R.sup.14 or a substituent (optionally substituted with R.sup.14) selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl;R.sup.3, R.sup.4 and R.sup.5 are independently H or C.sub.1-6 alkyl, or R.sup.3 and R.sup.4 may together represent a bond;R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are independently H, R.sup.10, or a group (optionally substituted with R.sup.10) selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, C.sub.1-6 alkyl-heteroaryl, heteroaryl, and heterocycloalkyl, orR.sup.6 and R.sup.7, R.sup.7 and R.sup.8, R.sup.8 and R.sup.9, or when n=1, R.sup.5 and R.sup.6, and the carbons to which they are independently attached may alternatively form an aryl, heteroaryl, cycloalkenyl or hetercycloalkenyl ring, wherein said ring is optionally substituted with R.sup.10 or R.sup.11 ;R.sup.10 is selected from the group consisting of C.sub.1-6 alkyl, Br, I, F, CN, NO.sub.2, N(R.sup.11).sub.2, OR.sup.11, COR.sup.11, CO.sub.2 R.sup.15, CON(R.sup.11).sub.2, C.dbd.NOR.sup.11, NR.sup.11 R.sup.12, S(O).sub.0-2 R.sup.11, and SO.sub.2 N(R.sup.11).sub.2 ;R.sup.11 is selected from the group consisting of H, C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, heterocyloalkyl, and C.sub.1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R.sup.13, COR.sup.13, SO.sub.0-2 R.sup.13, CO.sub.2 R.sup.13, OR.sup.13, CONR.sup.15 R.sup.13, NR.sup.15 R.sup.13, halogen, CN, SO.sub.2 NR.sup.15 R.sup.13 or NO.sub.2, and for each case of N(R.sup.11).sub.2 the R.sup.11 groups are the same or different or N(R.sup.11).sub.2 is heterocycloalkyl optionally substituted with a substituent selected from the group consisting of R.sup.13, COR.sup.13, SO.sub.0-2 R.sup.13, CO.sub.2 R.sup.13, OR.sup.13, CONR.sup.15 R.sup.13, NR.sup.15 R.sup.13, halogen, CN, SO.sub.2 R.sup.15 R.sup.13, and NO.sub.2 ;R.sup.12 is selected from the group consisting of COR.sup.11, CON(R.sup.11).sub.2, CO.sub.2 R.sup.13, and SO.sub.2 R.sup.13 ;R.sup.13 is selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, and C.sub.1-6 alkyl-heteroaryl;R.sup.14 is selected from the group consisting of OR.sup.11, COR.sup.11, CO.sub.2 R.sup.15, CON(R.sup.11).sub.2, NR.sup.11 R.sup.12, S(O).sub.0-2 R.sup.13, SO.sub.2 N(R.sup.11).sub.2, halogen, CN, NO.sub.2, and cycloimidyl (optionally substituted with R.sup.15); andR.sup.15 is H or C.sub.1-6 alkyl;and salts, solvates, hydrates, N-oxides, protected amino, protected carboxy, and protected hydroxamic acid derivatives thereof.