Patent ID: 6706743
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A compound of Formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of said compounds, and stereoisomers, wherein:Ar is phenyl; R is â€”NR9SO2R10, or â€”SO2R9; R1 is hydrogen, â€”(C1-C6)alkyl, halogen, â€”(C1-C6)alkoxy, or hydroxy; R2, R3, R4are, independently, hydrogen, or â€”(C1-C6)alkyl; R5 is an aromatic 5- or 6-membered ring heterocycle having from 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen; R6 and R7 are, independently, hydrogen, halogen, cyano, â€”(C1-C6)acyl, â€”CO2R9, â€”NR9R10, hydroxy, â€”(C1-C6)alkoxy, â€”CONR9R10, â€”NR9SO2R10, â€”SO2NR9R10, or â€”SO2R9; â€”(C1-C6)alkyl, optionally substituted with â€”(C3-C8)cycloalkyl, halogen, aryl, â€”(C1-C6)alkoxy, â€”(C1-C6)haloalkyl, alkylalkoxy, hydroxy, â€”NR9SO2R10, â€”SO2NR9R10, â€”SO2R9, or heterocycle; â€”(C3-C8)cycloalkyl, optionally substituted with â€”(C1-C6)alkyl, â€”(C3-C8)cycloalkyl, halogen, aryl, â€”(C1-C6)alkoxy, â€”(C1-C6)haloalkyl, alkylalkoxy, hydroxy, â€”NR9R10, â€”NR9SO2R10, â€”SO2NR9R10, â€”SO2R9, or heterocycle; aryl, optionally substituted with â€”(C1-C6)alkyl, â€”(C3-C7)cycloalkyl, halogen, aryl, â€”(C1-C6)alkoxy,â€”(C1-C6)haloalkyl, alkylalkoxy, hydroxy, â€”NR9R10, â€”NR9SO2R10, â€”SO2NR9R10, â€”SO2R9, or heterocycle; or heterocycle, optionally substituted with â€”(C1-C6)alkyl, â€”(C3-C8)cycloalkyl, halogen, aryl, â€”(C1-C6)alkoxy, â€”(C1-C6)haloalkyl, alkylalkoxy, hydroxy, â€”NR9R10, â€”NR9SO2R10, â€”SO2NR9R10, â€”SO2R9, or heterocycle; R8 is hydrogen, â€”(C1-C4)alkyl, or halogen; and R9 and R10 are, independently, hydrogen, â€”(C1-C6)alkyl, alkylalkoxy, â€”(C3-C8)cycloalkyl, â€”(C1-C6)haloalkyl, â€”(C1-C6)alkoxy, aryl, or heterocycle; X is a direct bond or oxygen; and Y is a direct bond, â€”(C1-C6)alkyl, â€”OCH2â€”, â€”CH2Oâ€”, or oxygen; provided that when R is â€”NR9SO2R10, and R6 and R7 are both hydrogen, then R5 is not imidazolyl.