Patent ID: 8907117
Filing Date: 2014-12-09
Classification: C07C

Abstract:
1. A method for the synthesis of (E)-3-(cinnamoyloxy)-2-hydroxypropyl 3-(3,4-dimethoxyphenyl)acrylate comprising the steps of: i) providing a first reactant comprising phosphonium bromide [((E)-(2-(3-(3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydroxypropoxy)-2-oxoethyl)triphenylphosphonium bromide)]; ii) converting said first reactant to a triphenyl phosphonium ylide [(E)-(2-(3-(3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydroxypropoxy)-2-oxoethyl)triphenylphosphonium ylide]; iii) providing a second reactant comprising benzaldehyde; iv) reacting the triphenyl phosphonium ylide provided in step ii) with the second reactant provided in step iv) to form one or more covalent bond(s) coupling said triphenyl phosphonium ylide with the second reactant to yield a dimethoxydicinnamate compound of the formula (E)-3-(cinnamoyloxy)-2-hydroxypropyl 3-(3,4-dimethoxyphenyl)acrylate.