Patent ID: 7790883
Filing Date: 2010-09-07
Classification: A61P,C07D

Abstract:
1. A method for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: in which R R (a) halogen atoms, —OR (b) a 3-8 membered ring optionally containing one or more atoms selected from O, S, NR (c) a phenyl group, a naphthyl group, or a 5- or 6-membered heteroaryl group containing one or more heteroatoms selected from N, S, and O, wherein the phenyl group, the naphthyl group, and the 5- or 6-membered heteroaryl group are each optionally substituted by one or more substituents independently selected from halogen atoms, cyano, nitro, —OR R R or R R each of R which method comprises contacting wherein L is a leaving group with a thiazole nitrogen protecting group reagent under appropriate reaction conditions to form a compound of the formula wherein PG is a protecting group, reacting the compound of formula III with an amine of formula HNR and deprotection of the compound of formula II to give a compound of the formula I, and simultaneous or sequential conversion to a pharmaceutically acceptable salt thereof.