Patent ID: 6545168
Filing Date: 2003-04-08
Classification: C07C,C07D,C07F

Abstract:
A compound having the formula: whereinM comprises ammonium or is a metal; R2 is â€”OT2, â€”OCOZ2, or â€”OCOOZ2; R4 is â€”OT4, â€”OCOZ4, or â€”OCOOZ4; R6 is hydrogen, keto, â€”OT6, â€”OCOZ6 or â€”OCOOZ6; R7 is hydrogen, halogen, â€”OT7, â€”OCOZ7 or â€”OCOOZ7; R9 is hydrogen, keto, â€”OT9, â€”OCOZ9 or â€”OCOOZ9, wherein â€”OT9, â€”OCOZ9 or â€”OCOOZ9 have the beta stereochemical configuration; R10 is hydrogen, keto, â€”OT10, â€”OCOZ10 or â€”OCOOZ10, wherein â€”OT10, â€”OCOZ10 or â€”OCOOZ10 have the beta stereochemical configuration; R6 and R7 independently have the alpha or beta stereochemical configuration; R13 is keto, MOâ€”, hydroxy, protected hydroxy, or T2, T4, T6, T7, T9 and T10 are independently hydrogen or hydroxy protecting group; X1 is â€”OX6; X2 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, or heteroaryl; X3 and X4 are independently hydrogen, hydrocarbon, heterosubstituted hydrocarbon, or heteroaryl; X5 is â€”COX10, â€”COOX10, â€”COSX10, or â€”CONX8X10; X6 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, or hydroxy protecting group or a functional group which increases the water solubility of the taxane compound; X8 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon; X10 is hydrocarbon, heterosubstituted hydrocarbon, or heteroaryl; and Z2, Z4, Z6, Z7, Z9 and Z10 are independently hydrocarbon, heterosubstituted hydrocarbon, or heteroaryl.