Patent ID: 6752990
Filing Date: 2004-06-22
Classification: C07K

Abstract:
A method for in vivo treatment of a mammal having a TAG-72-expressing cancer comprising a step of administering to the mammal a therapeutically effective amount of a composition suitable for the treatment of cancer, said composition containing either:A) a therapeutically effective amount of a humanized antibody directly or indirectly attached to an effector moiety having therapeutic activity, said humanized antibody having binding specificity to TAG-72 and said humanized antibody comprising: 1) at least one NEWM-grafted humanized heavy chain variable region (VH) having the amino acid sequence of any one of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6; and 2) at least one REI-grafted humanized light chain variable region (VL) having the amino acid sequence of SEQ ID NO:9; or B) a therapeutically effective amount of a humanized antibody fragment directly or indirectly attached to an effector moiety having therapeutic activity, said fragment being a fragment of the humanized antibody of Part A) and said humanized antibody fragment having binding specificity to TAG-72.