Patent ID: 6166213
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A process for the preparation of omeprazole, having the formula I, ##STR4## which comprises: (a) treating, at about -5 to +5.degree. C., a buffered solution of pyrmetazole, having the formula II, in a non-alcoholic organic ##STR5## reaction solvent, with one equivalent, relative to the number of moles of said pyrmetazole, of meta-chloroperoxybenzoic dissolved in the non-alcoholic organic reaction solvent in admixture with an alcoholic solvent at about 0-5.degree. C. followed by aging in the presence of an aqueous base;(b) separating the aqueous phase of the aged reaction mixture from the organic phase; and(c) removing residual non-alcoholic organic reaction solvent from said aqueous phase followed by re-adjusting the alcoholic solvent concentration to about 15% v/v.