Patent ID: 6544982
Filing Date: 2003-04-08
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula whereinn is 0, 1, or 2; m is 0, 1, or 2; R is hydrogen, C1-10 alkyl, C1-10 alkoxy, aryl, halogen, CF3, â€”OCH3, SCH3, SOCH3, SO2CH3, NO2, CN, or R, in combination with R1, form a 5-membered heterocyclic ringhaving 1 or 2 heteroatoms selected from N, O and S; R1 is hydrogen, C1-10 alkyl, C1-10 alkoxy, aryl, halogen, CF3, â€”OCH3, SCH3, SOCH3, SO2CH3, NO2, CN, or R1, in combination with R, form a 5-membered heterocyclic ring having 1 or 2 heteroatoms selected from N, O and S; R2 is hydrogen, C1-10 alkyl, C1-10 alkoxy, halogen, or CN; R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, C3-10 cycloalkyl, CH2C3-10 cycloalkyl, (CH2)2R7, CH2R7, CN, CH(CH3)R7, R7, R3, in combination with R4, forms a mono ring system selected from the group consisting of; a) a 4-8 membered saturated, partially saturated or unsaturated ring having a nitrogen atom, unsubstituted or substituted with 1) pyridine, 2), COOEt, 3) piperidine, 4) CONH2, 5) C1-4 alkyl, R4 is hydrogen, C1-10 alkyl, C2-10 alkenyl, C3-10 cycloalkyl, CH2C3-10 cycloalkyl (CH2)2R7, CH2R7, CN, CH(CH3)R7, R7, R4, in combination with R3, forms a mono ring system selected from the group consisting of; a) a 4-8 membered saturated, partially saturated or unsaturated ring having a nitrogen atom, unsubstituted or substituted with 1) pyridine, 2) COOEt, 3) piperidine, 4) CONH2, 5) C1-4 alkyl, R5 is hydrogen, C1-10 alkyl, C1-10 alkoxy, CN, OCF3, â€”O(CH2)0-2R8 â€”COOCH2CH3, NO2, CF3, aryl, unsubstituted, monosubstituted or disubstituted with OCH3, halogen, CN, NO2, CF3, OCF3, OCH2Ph, OCH2CH2Ph, COOEt C1-4 alkyl, or phenyl, phenyloxy, halogen, or R5 and R6 form a 5 membered heterocyclic ring having 1 or 2 heteroatoms selected from N, O and S; R6 is hydrogen, C1-10 alkyl, C1-10 alkoxy, CN, OCF3, â€”O(CH2)0-2R8 â€”COOCH2CH3, NO2, CF3, aryl, unsubstituted, monosubstituted or disubstituted with OCH3, halogen, CN, NO2, CF3, OCF3, OCH2Ph, OCH2CH2Ph, COOEt, C1-4 alkyl, or phenyl, phenyloxy, halogen, or R6 and R5 form a 5 membered heterocyclic ring having 1 or 2 heteroatoms selected from N, O and S; R7 is phenyl, CH2OCH3, C3-6 cycloalkyl, R8 is phenyl; and Ar1 is aryl or heteroaryl; Ar2 is naphthyl, anthracyl or heteroaryl; and Q is â€”CH2C3-10 cycloalkyl, or â€”(CH2)m(Ar2(R5)(R6)).