Patent ID: 6303575
Filing Date: 2001-10-16
Classification: A61K,A61P,C07K

Abstract:
An indolicidin analog having the amino acid sequence:Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Pro-Xaa6-Xaa6-Pro-Xaa6-Xaa7-Xaa7-Xaa8,wherein:Xaa1 is Ile, Leu, Val, Ala, Gly or absent;Xaa2 is Ile, Leu, Val, Ala, Gly or absent;Xaa3 is Pro or absent;Xaa4 is Trp, Phe or absent;Xaa5 is Arg, Lys or absent;Xaa6 is Trp or Phe;Xaa7 is Arg or Lys; andXaa8 is homoserine (Hse), Met or Met-Xaa9-Met;wherein Xaa9 is at least one amino acid;and further provided thatif Xaa2 is absent, Xaa1 is absent;if Xaa3 is absent, Xaa1 and Xaa2 are absent;if Xaa4 is absent, Xaa1, Xaa2 and Xaa3 are absent; andif Xaa5 is absent, Xaa1, Xaa2, Xaa3 and Xaa4 are absent.