Patent ID: 7601725
Filing Date: 2009-10-13
Classification: A61P,C07D

Abstract:
1. A compound of the formula: or pharmaceutically acceptable salt thereof; wherein one of - - - - - is a double bond, as valency permits; X W Alk L Y is a thiazolyl ring; and Z is an aliphatic, heteroaliphatic, alicyclic, aromatic, pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidinyl, piperazinyl, oxazolidinyl, isoxazolidinyl, morpholinyl, thiazolidinyl, isothiazolidinyl, tetrahydrofuryl, pyridyl, quinolinyl, dihydroquinolinyl, isoquinolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, or furanyl moiety, or Z has one of the following structures: wherein Z is optionally substituted with aliphatic; heteroaliphatic; alicyclic; heteroalicyclic; aromatic, aryl; heteroaryl; alkylaryl; alkylheteroaryl; alkoxy; aryloxy; heteroalkoxy; heteroaryloxy; alkylthio; arylthio; heteroalkylthio; heteroarylthio; F; Cl; Br; I; —NO wherein each heteroalicyclic group is selected from pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidinyl, piperazinyl, oxazolidinyl, isoxazolidinyl, morpholinyl, thiazolidinyl, isothiazolidinyl, tetrahydrofuryl, dihydropyrrolyl, dihydropyridyl, or azetidinyl, and wherein each heteroaryl group is selected from pyridyl, quinolinyl, dihydroquinolinyl, isoquinolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, or furanyl.