Patent ID: 8163698
Filing Date: 2012-04-24
Classification: A61K,A61P,C07K,C12P

Abstract:
1. A compound of the formula wherein r and s are 0; A is an α-amino acid derivative of Formula III wherein R B is valyl, isoleucyl, or 2-tert-butylglycyl; D is N-methylvalyl or N-methylisoleucyl; E is prolyl, thiazolidinyl-4-carbonyl or 3,4-didehydroprolyl; F is prolyl; and L is N-benzylamide, N-methoxy-N-benzylamide, tert-butylamide, tert-butyl ester, N-methoxy-N-methylamide, isopropylamide, 5-phenyl isoxasolidinyl, isoxazolidinyl, pentylamide, (R) or (S) phenethylamide, —O-tert-butyl, isoxazolidinyl, 5-phenyl isoxazolidinyl, or a pharmaceutically acceptable salt thereof.