Patent ID: 6440936
Filing Date: 2002-08-27
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A method of treating a protozoan infection comprising administering to a subject infected with a protozoan species selected from the group consisting of Toxoplasma gondii, Leishmania species, Trypanosoma cruzi, and Plasmodium species:a) an anti-protozoan agent selected from the group consisting of chloroquine, quinine, mefloquine, amodiaquine, primaquine, pyrimethamine, sulfadoxine, sulfadiazine, trimethoprim, pentavalent antimony, pentamidine, amphotericin B, rifampin, metronidazole, ketoconazole, benznidazole and nifurtimox, and b) a bactericidal/permeability-increasing (BPI) protein product, said BPI protein product being BPI holoprotein, a BPI fragment, a BPI variant, a BPI analog, or a BPI-derived peptide, or dimeric forms thereof, wherein said anti-protozoan agent and BPI protein product are administered in therapeutically effective amounts.