Patent ID: 6630500
Filing Date: 2003-10-07
Classification: A61K,A61P,C07D

Abstract:
Compounds of Formula I: wherein:R1 and R2 are the same or different and are independently selected from H, or alkyl of 1-8 carbons, substituted with â€”OH, or â€”OR4 where R4 is an alkyl of 1-4 carbons, aryl or the residue of an amino acid after the hydroxyl group of the carboxyl group is removed; and R3 is â€”CH2OH; â€”CH2OR7; â€”(CH2)nSR5; â€”(CH2)nS(O)yR5; â€”CH2SR5; or alkyl of 1-8 carbons substituted with â€”OH, â€”OR5, â€”OR8, â€”CH2OR7, â€”S(O)yR6 or â€”SR6; and wherein R5 is alkyl of 1-4 carbons or aryl; R6 is H, alkyl of 1-4 carbons or aryl of 6-10 carbons; R7 is H or alkyl of 1-4 carbons; R8 is the residue of an amino acid after the hydroxyl group of the carboxyl group is removed; n is an integer of 1-4; and y is 1 or 2; with the proviso that when R1 is (CH2)3OH and R2 is H, then R3 cannot be â€”CH2OH, â€”CH2OCH2CH3, or â€”CH2SCH2CH3.