Patent ID: 6143490
Filing Date: 2000-11-07
Classification: A61K,A61L,A61P,C07D,C12N

Abstract:
An in vitro method of treating mammalian blood or a blood product to inactivate a viral, bacterial or protozoan pathogen, the method comprising:(a) contacting in vitro a mammalian blood or blood product with a viral, bacterial or protozoan pathogen inactivating amount of a compound I, wherein,(i) compound I has an intercalator nucleic acid binding ligand and a mustard group attached thereto, and(ii) compound I when incubated with a composition comprising a blood product containing R17, has a greater inactivation efficiency against R17 than a compound II containing a mustard group that lacks the intercalator nucleic acid binding ligand, and(iii) the treating with the pathogen inactivating amount of Compound I results in the inactivation of at least 1 log of pathogen present in the blood or blood product, if any; and(b) recovering the pathogen inactivated mammalian blood or blood product, wherein the recovered product has substantially the same biological activity such that it is suitable for therapeutic use in a mammal.