Patent ID: 6117885
Filing Date: 2000-09-12
Classification: C07D

Abstract:
A compound of the formula I ##STR57## or pharmaceutically acceptable salts thereof; whereinA, B, D and E are each carbon atoms;X is --O--, --S--, --SO-- or --SO.sub.2 --;R.sub.1 and R.sub.2 are substituents on A, B, D or E when A, B, D or E are carbon and are independently selected from hydrogen; alkyl of 1 to 4 carbon atoms optionally substituted with substituents selected from amino, hydroxy or alkoxy of 1 to 4 carbon atoms; alkoxy of 1 to 4 carbon atoms, halogen; hydroxy; haloalkyl; cyano; nitro; amino; alkylamino or dialkylamino of up to 6 carbon atoms; (dialkylamino)alkyl of 3 to 8 carbon atoms; alkanoyl of 1 to 4 carbon atoms; carbamoyl; (N-alkyl)carbamoyl or di(N-alkyl)carbamoyl of up to 7 carbon atoms; carboxy; alkoxycarbonyl of 1 to 4 carbon atoms; alkylthio of 1 to 6 carbon atoms; alkylsulphinyl of 1 to 6 carbon atoms; alkylsulphonyl of 1 to 6 carbon atoms;R.sub.3 is --CO.sub.2 H, --CO.sub.2 R.sub.7, --CHO, --CONHOR.sub.10, --CONHR.sub.8, --CONR.sub.8 R.sub.8 ', --CONH.sub.2 or --CONHSO.sub.2 CF.sub.3 ;R.sub.4 is hydrogen, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, or an alkyl substituted with 1 or more fluorine atoms;R.sub.5 is an optional oxygen atom; ##STR58## R.sub.7 is alkyl, aryl, arylalkyl, aryloxyalkyl, --CH.sub.2 --COOR.sub.8 ##STR59## or indanyl; R.sub.8 and R.sub.8 ' are independently a lower alkyl;R.sub.9 is hydrogen, alkyl, perfluoroalkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenyl, benzyl ##STR60## R.sub.10 is hydrogen, alkyl, aryl, arylalkyl or cycloalkyl; R.sub.11 is alkyl, aryl, arylalkyl or cycloalkyl;R.sub.12 is hydrogen, alkyl of 1 to 5 carbon atoms or phenyl;R.sub.13 is --CN, --NO.sub.2 or --CO.sub.2 R.sub.9 ;the term ""alkyl"" refers to both straight and branched chain groups having 1 to 10 carbon atoms;the term ""alkenyl"" and ""alkynyl"" refer to both straight and branched chain groups having 2 to 10 carbon atoms;the term ""aryl"" refers to phenyl or naphthyl or phenyl or naphthyl substituted with one or more substituents selected from halogen, alkyl, alkoxy, carboxy, alkylthio, hydroxy, alkanoyl, nitro, amino, alkylamino, dialkylamino or trifluoromethyl groups; andthe term ""cycloalkyl"" refers to groups having 3 to 8 carbon atoms.