Patent ID: 8920805
Filing Date: 2014-12-30
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting lymphatic endothelial cell migration, comprising administering to a mammalian subject in need an effective amount of an anti-neuropilin2B (anti-Nrp2B) antibody, or an antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment: i) comprises complementarity determining region light chain (CDRL)1, CDRL2, and CDRL3 sequences and complementarity determining region heavy chain (CDRH)1, CDRH2, CDRH3 sequences of an antibody selected from the group consisting of YW68.4.2 and YW68.4.2.36; ii) is a variant of the antibody of (i) having one to five alterations in the framework regions, wherein the light chain framework regions comprise residues 1-23, 35-49, 57-88 and 98-107 or 1-25, 33-49, 53-90 and 97-107 and the heavy chain framework regions comprise residues 1-30, 36-49, 66-94 and 103-113 or 1-25, 33-52, 56-95 and 102-113; or iii) is an affinity matured variant of the antibody of (i).