Patent ID: 7670777
Filing Date: 2010-03-02
Classification: C12Q

Abstract:
1. A method for DNA methylation analysis of a genomic DNA sample, said method comprising the steps of: a) converting a genomic DNA sample by a copying reaction so that methylated positions in the genomic DNA sample become hemimethylated whereas unmethylated positions in the genomic DNA sample remain unmethylated; b) then, treating the genomic DNA sample with at least one labeled S-adenosylmethionine derivate and a methyltransferase specific for hemimethylated double-stranded DNA, whereby the at least one labeled S-adenosylmethionine derivate becomes incorporated into the genomic DNA sample at previously methylated positions; and c) then, detecting the presence of the at least one labeled S-adenosylmethionine derivate.