Patent ID: 7332320
Filing Date: 2008-02-19
Classification: A61K,A61Q,C11D,C12N

Abstract:
1. A variant of a subtilisin comprising a T-cell epitope, wherein said subtilisin variant has proteolytic activity and an amino acid sequence at least 85% identical to the amino acid sequence set forth in SEQ ID NO:2 and differs from said subtilisin by having an altered T-cell epitope such that said subtilisin variant exhibits an altered immunogenic response from said subtilisin in a human; wherein said altered T-cell epitope of said subtilisin variant comprises an amino acid substitution of glycine, isoleucine, leucine, methionine, phenylalanine, proline, tryptophan, or tyrosine at an amino acid position corresponding to position 26 of SEQ ID NO:2.