Patent ID: 6384070
Filing Date: 2002-05-07
Classification: A61P,C07D

Abstract:
A compound of formula I, whereinR1 and R2 are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl, optionally substituted by CO2H or CO2(C1-6 alkyl), C2-6 alkynyl, halogen C1-3 perfluoroalkyl, (CH2)mAr1, (CH2)mHet1, (CH2)mCONR7R8, (CH2)mCO2R8, O(CH2)qCO2R8, (CH2)mCOR8, (CH2)mOR8, O(CH2)pOR8, (CH2)mNR7R8, CO2(CH2)qNR7R8, (CH2)mCN, S(O)nR8, SO2NR7R8, CONH(CH2)mAr1 or CONH(CH2)mHet1; R3 represents H, C1-6 alkyl, (CH2)pNR9R10, SO2R10, SO2NR9R10, (CH2)mCOR10, C2-6 alkenyl, C2-6 alkynyl, (CH2)mCONR9R10, (CH2)mCO2R10, (CH2)pCN, (CH2)pR10 or (CH2)pOR10; R4 and R9 independently represent H or C1-6 alkyl; R7 represents H, C1-6 alkyl or C1-6 alkoxy; R5 represents H or OH; R6 represents methylenedioxyphenyl optionally substituted by one or more groups selected from C1-6 alkyl, C1-6 alkoxy and halogen; R8 and R10 independently represent H, C1-6 alkyl, Ar2, Het2 or C1-6 alkyl substituted by Ar2 or Het2; Z represents CO2H, CONH(tetrazol-5-yl), CONHSO2O(C1-4 alkyl), CO2Ar3, CO2(C1-6 alkyl), tetrazol-5-yl, CONHSO2Ar3, CONHSO2(CH2)qAr3 or CONHSO2(C1-6 alkyl); m represents 0, 1, 2 or 3; n represents 0, 1, or 2; p represents 2, 3 or 4; q represents 1, 2 or 3; Ar1-3 independently represent phenyl, naphthyl, or an aromatic heterocycle having 6 ring members 2 to 4 of which are selected from N, S and O, which aromatic heterocycle is optionally fused to a benzene ring, and which phenyl group is optionally fused to an aromatic heterocycle as defined immediately above, the group as a whole being optionally substituted by one or more groups falling within the definition of R1 above; and Het1 and Het2 independently represent a non-aromatic heterocycle having 6 ring members 2 to 4 of which are selected from N, S and O, which group is optionally substituted by one or more groups falling within the definition of R1 above, and is further optionally substituted by &boxH;O or &boxH;S; or a pharmaceutically acceptable salt thereof.