Patent ID: 8333962
Filing Date: 2012-12-18
Classification: A61K,A61P

Abstract:
1. A controlled release multidrug formulation comprising: a) a first composition comprising glial-derived neurotrophic factor (GDNF) or brain-derived neurotrophic factor (BDNF), encapsulated within a first polymeric particle; b) a second composition comprising chondroitinase ABC (ChABC), encapsulated within a second polymeric particle, wherein the second polymeric particle is encapsulated within the first polymeric particle; and c) optionally a third composition comprising a bioactive agent selected from the group consisting of cyclic AMP (cAMP), an adenylate cyclase activator and a Rho inhibitor, the third composition being encapsulated within either the first or the second polymeric particle, wherein chondroitinase ABC (ChABC) of the second composition is released subsequently to the release of the first composition.