Patent ID: 6372914
Filing Date: 2002-04-16
Classification: C07D,Y02P

Abstract:
A (4R)-[3-[2-(&ohgr;-substituted alkyl)-3-(R)-hydroxy-1-oxo-3-(2S,4R)-2-pyrrolidinyl]propyl]-oxazolidin-2-one (or thiazolidine-2-thione) compound represented by the formula (I): wherein R1 is selected from the group consisting of methylsulfonyl, ethylsulfonyl, propylsulfonyl, phenylsulfonyl, p-toluenesulfonyl, trimethylsilyl, triethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl and vinyldimethylsilyl; R2 is a protecting group selected from the group consisting of formyl, acetyl, chloroacetyl, dichloroacetyl, propionyl, phenylacetyl, thienylacetyl, t-butoxycarbonyl, benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, p-methoxybenzyloxycarbonyl, p-bromobenzyloxycarbonyl and 2,4-dichlorobenzyloxycarbonyl; R3 is a substituted or unsubstituted lower alkyl group or an aryl group; X is an oxygen atom or a sulfur atom; Y is an azide group or a nitro group; and n is an integer of 1 to 4.