Patent ID: 8518969
Filing Date: 2013-08-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I wherein: A is X is N; Z is N; J is N or CH; Q is C—R R or unsubstituted or substituted C (1-6) alkyl wherein said alkyl may be substituted with up to two substituents wherein one substituent is selected from the group consisting of OH, C (2-4) alkenyl, C (3-6) cycloalkyl, NH 2 , NHBOC, N(C (1-4) alkyl) 2 , NHSO 2 R b , NR b C(O)R bb , NHCO 2 R b , NHCONR b R bb , OC (1-2) alkyl, OC(O)C (1-4) alkyl, OC(O)NR b R bb , CO 2 C (1-4) alkyl, C(O)NR b R bb , C (2) alkylnyl, thiazolyl, oxazolyl, furyl, CF 3 , CF 2 CF 2 CF 3 , CH 2 NHCOC (1-3) alkyl, N 3 , SCH 3 , S(O)CH 3 , SO 2 CH 3 and —CN, and the second substituent on the C (1-6) alkyl is OH, and wherein said phenyl or heteroaryl is optionally substituted with one substituent selected from the group consisting of: OH, —CN, CH 2 OH, OC (1-4) alkyl, NH 2 , NHC (1-4) alkyl, OC (1-4) alkyl, C(O)C (1-4) alkyl, CO 2 C (1-4) alkyl, C(O)NHC (1-4) alkyl, CO 2 NHC (1-4) alkyl, SC (1-4) alkyl, SOC (1-4) alkyl, SO 2 C (1-4) alkyl, SO 2 NHC (1-4) alkyl, NHSO 2 C (1-4) alkyl, NHCO 2 C (1-4) alkyl, NHC(O)C (1-4) alkyl, NO 2 , and C (1-4) alkyl; R or R R R R R R R and pharmaceutically acceptable salts thereof.