Patent ID: 8221787
Filing Date: 2012-07-17
Classification: A61K,A61P

Abstract:
1. A pharmaceutical preparation for oral administration with controlled release of active ingredient in the small bowel comprising: a) active ingredient carriers comprising (1R,3r,5S)-3-[(hydroxydiphenylacetyl)oxy]spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium]chloride as the active agent, and optionally a binder, buffer substances, a plasticizer and/or an antitack agent; b) an inner layer coated on the active ingredient carriers to control the release of active ingredient comprising: c) optionally, a gastro-resistant coating layer disposed thereon, wherein the permeability for the diffusing active ingredient decreases from the inside to the outside; and wherein <75% of the active agent of the pharmaceutical preparation is released in 60 minutes releasing the active agent at a constant rate.