Patent ID: 7491383
Filing Date: 2009-02-17
Classification: A61K,A61P

Abstract:
1. A liquid composition comprising: an ophthalmically acceptable cationic therapeutic component selected from the group consisting of NMDA antagonists, antibacterials, antihistamines, decongestants, antiinflammatories, antiparasitics, miotics, anticholinergics, adrenergics, antivirals, local anesthetics, antifungals, amoebicidals, trichomonocidals, analgesics, mydriatics, antiglaucoma drugs, carbonic anhydrate inhibitors, ophthalmic diagnostic agents, ophthalmic agents used as adjuvants in surgery, chelating agents, antineoplastics, antihypertensives, muscle relaxants, diagnostics, and mixtures thereof in a therapeutically effective amount, and an efficacy enhancing component having one, two or three negative charges provided in an amount greater than 0.2% (w/v) and less than about 10% (w/v) and being effective to enhance the pharmacokinetic disposition of the therapeutic component, to enhance the movement of the therapeutic component across a lipid membrane, or a biological membrane under physiological conditions, and to enhance the permeability of the therapeutic component, the efficacy enhancing component being present in an ion pair complex at a molar ratio of 1:3, 1:2, 1:1, 2:1 or 3:1 with the therapeutic component, from about 80% to about 100% of the therapeutic component present in complex with the efficacy enhancing component, the ion-pair complex remaining substantially intact in an aqueous environment, each of the enhanced effects being relative to the effect obtained with the therapeutic component without the efficacy enhancing component; and a solubilizer component provided in an amount effective to enhance the solubility of the ion-pair complex in solution.