Patent ID: 8367324
Filing Date: 2013-02-05
Classification: C12Q,G01N

Abstract:
1. A method for determining an amount or presence/absence of a change in a probe-bearing substrate in which a nucleic acid probe capable of specifically binding to a target substance is immobilized on the substrate, the probe-bearing substrate further including a device for detecting an environmental change that causes the change in the probe-bearing substrate, the method comprising: exposing the probe-bearing substrate to an environment; measuring a color change of the device and a level of the change in the probe-bearing substrate in advance of the nucleic acid probe binding to the target substance; and determining the amount or presence/absence of the change in the probe-bearing substrate based on a level of the color change of the device, wherein the environmental change is at least one of a change in temperature and a change in exposure to ultraviolet light, and wherein the device is attached to the probe-bearing substrate at a different position from the immobilized probe.