Patent ID: 6521626
Filing Date: 2003-02-18
Classification: A61P,C07D,Y10S

Abstract:
A compound of formula (1): wherein R1 is an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Alk1 is an alkyl group; L1 is an oxygen atom; r is zero or the integer 1; s is the integer 1; R2 and R3, which may be the same or different, is each a hydrogen or halogen atom, a hydroxyl or nitro group, or a straight or branched alkyl, haloalkyl, alkoxy, or haloalkoxy group; Alk2 is a straight or branched alkylene chain; m is zero or an integer 1; R4 is a hydrogen atom or a methyl group; R5 is a hydrogen atom or a straight or branched alkyl group; R6 is a group â€”(CH2)tR7 in which t is zero or the integer 1 and R7 is an optionally substituted polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; R is a carboxylic acid (â€”CO2H) or a derivative thereof; and the salts, solvates and hydrates thereof; with the proviso that at least one of R1 or R7 is a heterocycloaliphatic, polyheterocycloaliphatic, or heteroaromatic group.