Patent ID: 7772373
Filing Date: 2010-08-10
Classification: A61K,A61P,C07K

Abstract:
1. A humanized anti-CD74 antibody, wherein said antibody is internalized by Raji lymphoma cells in culture and said antibody induces apoptosis of Raji cells in cell culture when cross-linked with goat antisera reactive with the Fc of a human IgG, wherein said antibody competes for binding to CD74 with an anti-CD74 antibody comprising the light chain complementarity-determining region (CDR) sequences CDR1(RSSQSLVHRNGNTYLH; SEQ ID NO:19), CDR2 (TVSNRFS; SEQ ID NO:20), and CDR3(SQSSHVPPT; SEQ ID NO:21) and the heavy chain CDR sequences CDR1 (NYGVN; SEQ ID NO:22), CDR2 (WINPNTGEPTFDDDFKG; SEQ ID NO:23), and CDR3 (SRGKNEAWFAY; SEQ ID NO:24).