Patent ID: 6589950
Filing Date: 2003-07-08
Classification: A61K,A61P,C07D

Abstract:
A compound of formula in free or salt form, whereinX is an oxygen or sulfur atom or a group NR5, R1 is an alkyl, alkenyl, cycloalkyl, benzocycloalkyl, cycloalkylalkyl or aralkyl group which optionally may be substituted by hydroxy, alkoxy, carboxy or alkoxycarbonyl or, when X is NR5, R1 may alternatively be a group of formula or a monovalent heterocyclic radical having up to 20 carbon atoms and one, two, three, or four heteroatoms selected from nitrogen, oxygen, and sulfur, the radical optionally having an alkyl, alkylcarbonyl, hydroxyalkyl, alkoxyalkyl, or aralkyl group attached to a ring carbon or nitrogen atom and being linked to the remainder of the molecule through a ring carbon atom, R2, R3, R4, R6, R7, and R8 are each independently hydrogen, halogen, alkyl, haloalkyl, alkoxy, carboxy, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, â€”N(R9)R10, â€”SO2N(R11)R12, C1-C4-alkylene-SO2N(R11)R12 or â€”CON(R13)R14 or, when two of R2, R3 and R4, or two of R6, R7 and R8, are attached to adjacent carbon atoms on the indicated benzene rings, they denote, together with the carbon atoms to which they are attached, a carbocyclic group having 5 to 10 ring atoms or a heterocyclic group having 5 to 10 ring atoms of which one, two or three are hetero atoms selected from nitrogen, oxygen and sulfur, R5 is hydrogen or alkyl, R9 is hydrogen or alkyl and R10 is hydrogen, alkyl or â€”COR15 where R15 is alkyl, haloalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, carboxyalkyl or alkoxycarbonylalkyl, or R9 and R10, together with the nitrogen atom to which they are attached, denote a heterocyclic group having 5 or 6 ring atoms of which one or two are hetero atoms selected from nitrogen, oxygen and sulfur, R11 is hydrogen or alkyl and R12 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or alkoxycarbonylalkyl, or R11 and R12 together with the nitrogen atom to which they are attached denote a heterocyclic group having 5 or 6 ring atoms of which one or two are hetero atoms selected from nitrogen, oxygen and sulfur, and when R9 and R10, or R11 and R12, together with the nitrogen atom to which they are attached, denote a heterocyclic group having two nitrogen atoms in the ring, said group may be optionally substituted on the second nitrogen atom by a C1-C4-alkyl, hydroxy-C1-C4-alkyl, C1-C4-alkylcarbonyl, a C1-C4-alkoxycarbonyl, or phenyl-C1-C4-alkyl group, and when R9 and R10, or R11 and R12, together with the nitrogen atom to which they are attached, denote a heterocyclic group having one nitrogen atom and one oxygen atom in the ring, said group may be optionally substituted on one or more ring carbon atoms by a C1-C4-alkyl group, and R13 and R14 are each independently hydrogen or alkyl; with the exception of 2-(p-n-butylanilino)-6-methoxypurine, 2-(p-n-butylanilino)-6-(methylthio)purine, 2,6-di(phenylamino)purine, 2,6-di(p-tolylamino)purine, and 2-(p-tolylamino)-6-(phenylamino)purine.