Patent ID: 7273620
Filing Date: 2007-09-25
Classification: A61K

Abstract:
1. A method of triggering the release of a therapeutic agent in a subject, the method comprising: administering intravenously a first liposome loaded with the therapeutic agent to a subject, the first liposome having a net positive or negative charge and comprising dioleoylphosphatidylethanolamine (DOPE) in an amount of at least 4 mole % and cholesterol in an amount of at least 10 mole %; and administering intravenously a trigger to the subject, the trigger comprising a second liposome having a net charge opposite to the first liposome and comprising DOPE in an amount of at least 4 mole % and cholesterol in an amount of at least 10 mole %; wherein said first and second liposome have a mean diameter of 0.05 to 0.2 microns, whereby the second liposome contacts the first liposome to trigger the release of the therapeutic agent.