Patent ID: 6713050
Filing Date: 2004-03-30
Classification: A61K,A61Q

Abstract:
A composition for the treatment of nails to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula (I): wherein R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy(lower alkyl), lower acyloxy(lower alkyl), lower alkyl, lower alkenyl, or R1 and R2 together with their ring carbons may be an aromatic fused ring, optionally substituted by one or more amino, halo or alkylenedioxy groups;Z is hydrogen or an amino group; Y is amino, or a group of the formula â€”CH2C(&boxH;O)â€”R wherein R is a lower alkyl, alkoxy, hydroxy, amino or aryl group; said aryl group optionally substituted by one or more lower alkyl, lower alkoxy, halo, dialkylamino, hydroxy, intro or alkylenedioxy groups, or a group of the formula â€”CH2Râ€² wherein Râ€² is hydrogen, or a lower alkyl, lower alkynyl, or aryl group, or a group of the formula â€”CH2C(&boxH;O)â€”N(Râ€³)Râ€²â€³ wherein (a) Râ€³ is hydrogen and Râ€²â€³ is a lower alkyl group optionally substituted by a C6-C10 aryl group, or a C6-C10 aryl group, said aryl groups optionally substituted by one or more lower alkyl, halo, or (lower alkoxy)carbonyl groups; or (b) Râ€³ and Râ€²â€³ are both lower alkyl groups; and X is a halide, tosylate, methanesulfonate, mesitylenesulfonate, or other pharmacologically acceptable anion and mixtures thereof, and a carrier therefore; wherein the effective amount is sufficient to treat at least one of the following: (a) damaged nails; (b) physiologically aged nails; and (c) diseased nails (e.g. diabetes); and wherein the composition is in the form of a nail polish.