Patent ID: 6020142
Filing Date: 2000-02-01
Classification: A01K,A61K,A61P,C07K,Y02A

Abstract:
A method for identifying a compound that modulates activity of a gene product encoded by a RATH nucleic acid molecule, said method comprising:(a) contacting a cell which expresses the RATH nucleic acid molecule with a test compound; and(b) determining whether the test compound modulates activity of the gene product encoded by the RATH nucleic acid molecule,wherein the RATH nucleic acid molecule comprises(i) a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, or the amino acid sequence encoded by the cDNA clone of ATCC Accession No. 98116;(ii) the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, or contained in the cDNA of ATCC Accession No. 98116; or(iii) a nucleotide sequence that hybridizes to the complement of a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, or the amino acid sequence encoded by the cDNA clone of ATCC Accession No. 98116 under conditions comprising incubation at 65.degree. C. in 0.5 M NaHPO.sub.4, 7% SDS, 1 mM EDTA followed by washing in 0.1.times. SSC/0.1% SDS at 68.degree. C.