Patent ID: 6057342
Filing Date: 2000-05-02
Classification: C07D

Abstract:
A compound of formula I: ##STR69## or stereoisomers or pharmaceutically acceptable salts thereof, wherein; one of D and D' is selected from CN, C(.dbd.NR.sup.7)NR.sup.8 R.sup.9, NHC(.dbd.NR.sup.7)NR.sup.8 R.sup.9, NR.sup.8 CH(.dbd.NR.sup.7), C(O)NR.sup.8 R.sup.9, and (CH.sub.2).sub.t NR.sup.8 R.sup.9 and the other is H;Z is selected from CH.sub.2, C.dbd.O, CH.sub.2 C(O), C(O)O, CONH, CH.sub.2 NH.sub.2, CH.sub.2 O, SO.sub.2, and SO.sub.2 NH;J.sup.1 and J.sup.2 are independently selected from O and CH.sub.2, provided that if J.sup.1 is O, then J.sup.2 is CH.sub.2 and if J.sup.2 is O, then J.sup.1 is CH.sub.2 ;R is selected from CO.sub.2 R.sup.1, COR.sup.1, OR.sup.1, NR.sup.2 R.sup.2a, CONR.sup.2 R.sup.2a, S(O).sub.p R.sup.1a, and S(O).sub.p NR.sup.2 R.sup.2a ;R.sup.a is selected from H and C.sub.1-4 alkyl;R.sup.b is H;when J.sup.1 and J.sup.2 are CH.sub.2, then R.sup.a and R.sup.b can combine to form a bond;R.sup.1 is selected from:H,C.sub.1-4 alkyl substituted with 0-1 R.sup.3,C.sub.3-6 carbocyclic group substituted with 0-2 R.sup.4, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;R.sup.1a is selected from:C.sub.1-4 alkyl substituted with 0-1 R.sup.3,C.sub.3-6 carbocyclic group substituted with 0-2 R.sup.4, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;R.sup.2 and R.sup.2a are independently selected from H, C.sub.1-4 alkyl, and phenyl;R.sup.2a may also be C.sub.1-4 alkoxy;R.sup.3 is selected from:phenyl substituted with 0-2 R.sup.4, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;A is selected from:C.sub.3-13 carbocyclic group substituted with 0-2 R.sup.4, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;B is selected from:X-Y, NR.sup.2 R.sup.2a, C(.dbd.NR.sup.2)NR.sup.2 R.sup.2a, NR.sup.2 C(.dbd.NR.sup.2)NR.sup.2 R.sup.2a,benzyl substituted with 0-2 R.sup.4a,C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.4a, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;X is selected from C.sub.1-4 alkylene, --C(O)--, --C(O)CR.sup.2 R.sup.2a --, --CR.sup.2 R.sup.2a C(O), --S(O).sub.p --, --S(O).sub.p CR.sup.2 R.sup.2a --, --CR.sup.2 R.sup.2a S(O).sub.p --, --S(O).sub.2 NR.sup.2 --, --NR.sup.2 S(O).sub.2 --, --NR.sup.2 S(O).sub.2 CR.sup.2 R.sup.2a --, --CR.sup.2 R.sup.2a S(O).sub.2 NR.sup.2 --, --NR.sup.2 S(O).sub.2 NR.sup.2 --, --C(O)NR.sup.2 --, --NR.sup.2 C(O)--, --C(O)NR.sup.2 CR.sup.2 R.sup.2a --, --NR.sup.2 C(O)CR.sup.2 R.sup.2a --, CR.sup.2 R.sup.2a C(O)NR.sup.2 --, --CR.sup.2 R.sup.2a NR.sup.2 C(O)--, --NR.sup.2 C(O)O--, --OC(O)NR.sup.2 --, --NR.sup.2 C(O)NR.sup.2 --, --NR.sup.2 --, --NR.sup.2 CR.sup.2 R.sup.2a --, --CR.sup.2 R.sup.2a NR.sup.2 --, O, --CR.sup.2 R.sup.2a O--, --OCR.sup.2 R.sup.2a --, and S;Y is selected from:C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.4, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.4 ;R.sup.4 is selected from OH, (CH.sub.2).sub.r OR.sup.2, halo, C.sub.1-4 alkyl, CN, NO.sub.2, (CH.sub.2).sub.r NR.sup.2 R.sup.2a, (CH.sub.2).sub.r C(O)R.sup.2, NR.sup.2 C(O)R.sup.2a, NR.sup.2 C(O)NR.sup.2 R.sup.2a, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2 NR.sup.2 R.sup.2a, NR.sup.2 SO.sub.2 NR.sup.2 R.sup.2a, NR.sup.2 SO.sub.2 --C.sub.1-4 alkyl, NR.sup.2 SO.sub.2 R.sup.5, S(O).sub.p R.sup.1a, and CF.sub.3 ;R.sup.4a is selected from OH, halo, C.sub.1-4 alkyl, NO.sub.2, (CH.sub.2).sub.r NR.sup.2 R.sup.2a, (CH.sub.2).sub.r C(O)R.sup.2, NR.sup.2 C(O)R.sup.2a, NR.sup.2 C(O)NR.sup.2 R.sup.2a, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2 NR.sup.2 R.sup.2a, NR.sup.2 SO.sub.2 NR.sup.2 R.sup.2a, NR.sup.2 SO.sub.2 --C.sub.1-4 alkyl NR.sup.2 SO.sub.2 R.sup.5, S(O).sub.p R.sup.1a, and CF.sub.3 ;R.sup.5 is selected from:C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6, andfuranyl, isoxazolidinyl, pyranyl, pyridyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, and thienyl substituted with 0-2 R.sup.6 ;R.sup.6 is selected from H, OH, (CH.sub.2).sub.r OR.sup.2, halo, C.sub.1-4 alkyl, CN, NO.sub.2, (CH.sub.2).sub.r NR.sup.2 R.sup.2a, (CH.sub.2).sub.r C(O)R.sup.2, NR.sup.2 C(O)R.sup.2a, NR.sup.2 C(O)NR.sup.2 R.sup.2a, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2 NR.sup.2 R.sup.2a, NR.sup.2 SO.sub.2 NR.sup.2 R.sup.2a, and NR.sup.2 SO.sub.2 --C.sub.1-4 alkyl;R.sup.7 is selected from H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxy, C.sub.1-4 alkoxycarbonyl, C.sub.6-10 aryloxy, C.sub.6-10 aryloxycarbonyl, C.sub.6-10 arylmethylcarbonyl, C.sub.1-4 alkylcarbonyloxy C.sub.1-4 alkoxycarbonyl, C.sub.6-10 arylcarbonyloxy C.sub.1-4 alkoxycarbonyl, C.sub.1-6 alkylaminocarbonyl, phenylaminocarbonyl, and phenyl C.sub.1-4 alkoxycarbonyl;R.sup.8 is selected from H, C.sub.1-6 alkyl and (CH.sub.2).sub.n -phenyl;R.sup.9 is selected from H, C.sub.1-6 alkyl and (CH.sub.2).sub.n -phenyl;n is selected from 0, 1, 2, and 3;m is selected from 0, 1, and 2;p is selected from 0, 1, and 2; and,r is selected from 0, 1, and 2.