Patent ID: 6723733
Filing Date: 2004-04-20
Classification: A61P,C07D

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein:R1 is hydrogen or halogen; R2 is hydrogen, hydroxyl, amino, nitroso, methyl, amino methyl or carboxylic acid; R4 is â€”QP and R3 is one of hydrogen, methyl, trifluoromethyl, nitro, amino, halogen and 1-piperazine, wherein Q is one of P is Zâ€”(N(R5R6)), Z or a 5 or 6 membered substituted or unsubstituted aromatic or non-aromatic ring which contains 0, 1, or 2 heteroatoms selected from the group consisting of O, N, S, wherein A is carbon or S&boxH;O, X is S or N; provided that, when X is S, then Y is absent, when X is N, then Y is hydrogen, C1-C6 straight or branched chain alkyl, optionally substituted alkoxy or alkyl amino, or Y and Z are taken together to form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic aromatic or non-aromatic ring which contains 1, 2 or 3 heteroatoms selected from O, N, S and mixtures combination; Z is hydrogen, a direct bond, a carbonyl, an optionally substituted C1-C5 straight or branched chain alkyl, cycloalkyl, carboxy, optionally substituted C1-C6 ether, aryl or heteroaryl, alkylalkenyl, alkynyl, alkylhalo, straight or branched chain or CH2COOH, provided that when P is Z, Z is not hydrogen or a direct bond or a carbonyl and R5 and R6 are independently hydrogen, lower alkyl, lower alkenyl, lower alkanol, heterocycle, heteroaryl, alkoxy, aryloxy, alkylamino, arylamino, CH2COOH, or R5 and R6 taken together form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O, N, S and combinations thereof.