Patent ID: 6060253
Filing Date: 2000-05-09
Classification: C07K,G01N

Abstract:
A monoclonal antibody that competes with a monoclonal antibody selected from the group consisting of MAb 512-1-8 (ATCC HB12266), and MAb 50-1-3 (ATCC HB-12267) for specific binding to human cytochrome p450 2D6 and specifically inhibits catalyzed metabolism of bufuralol human cytochrome P450 2D6 by at least 75%, wherein the monoclonal antibody of comprises a light chain variable domain having at least 80% sequence identity with the light chain variable domain of a monoclonal antibody selected from the group consisting of MAb 512-1-8 (ATCC HB-12266), and MAb 50-1-3 (ATCC HB-12267), the percentage sequence identity of the light chains being determined by alignment of amino acids by Kabat numbering; and a heavy chain variable domain having at least 80% sequence identity with the heavy chain variable domain of a monoclonal antibody selected from the group consisting of MAb 512-1-8 (ATCC HB-12266), and MAb 50-1-3 (ATCC HB-12267) the percentage sequence identity of the heavy chains being determined by alignment of amino acids by Kabat numbering.