Patent ID: 7999095
Filing Date: 2011-08-16
Classification: C12Q

Abstract:
1. A pair of complementation molecules comprising a) a first complementation molecule comprising a first polypeptide portion coupled to a first probe portion, wherein the first probe portion is capable of binding to a first nucleic acid hybridization site of a target nucleic acid molecule and b) a second complementation molecule comprising a second polypeptide portion coupled to a second probe portion, wherein the second probe portion is capable of binding to a second nucleic acid hybridization site of the target nucleic acid molecule, wherein the first and second probe portions are nucleic acids or nucleic acid analogues, and wherein the first and second polypeptide portions of the complementation molecules are capable of interacting and forming an assembled complementation complex when the first and second probe portions bind to nucleic acid hybridization sites that are located in close proximity to each other.