Patent ID: 6239272
Filing Date: 2001-05-29
Classification: C07H,C12N,C12Y

Abstract:
An oligonucleotide comprising one or more modified nucleotides, wherein said modified nucleotide has the formula: ##STR3##wherein, R1 is independently 2'-O-R3-thio-R3 or 2'-C-R3-thio-R3, wherein said R3 is independently a compound selected from a group consisting of alkyl, allyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester; X is independently a base or H; Y is independently a phosphorus-containing group; and R2 is independently O, blocking group or a phosphorus-containing group, wherein said modified nucleotides are linked by a 3',5' linkage in the oligonucleotide.