Patent ID: 7183414
Filing Date: 2007-02-27
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of the formula I or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof; wherein each R 1 , R 2 , and R 3 is independently selected from the group consisting of H, (C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkyl, halo, cyano, CF 3 , difluoromethoxy, trifluoromethoxy, —O(C 1 –C 6 )alkyl, —O(C 3 –C 6 )cycloalkyl, and —NR 12 R 13 ; wherein R wherein each R wherein each R wherein each R wherein each R wherein R wherein each of the aforesaid (C wherein BOC is t-butoxycarbonyl, and R 1 , R 2 , R 3 and R 4 are as defined above for the compound of formula I, with a metal alkoxide in the presence of water to give a compound of the formula I.