Patent ID: 7718676
Filing Date: 2010-05-18
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein substituents R1-R7 and X are defined as follows: R1, R2, R3 and R4 each independently are selected from hydrogen, halogen (selected from F, Cl, Br or I), a linear or branched alkyl group containing from 1 to 10 carbon atoms and optionally substituted with one or more hetereoatoms such as halogen (selected from F, Cl, Br or I), oxygen, and nitrogen, the latter optionally in the form of a pendant basic nitrogen functionality; as well as trifluoromethyl, C R5 is one of the following: (i) hydrogen, or (ii) a linear or branched alkyl group containing from 1 to 10 carbon atoms and optionally substituted with one or more hetereoatoms such as halogen (selected from F, Cl, Br or I), oxygen, and nitrogen, the latter optionally in the form of a pendant basic nitrogen functionality, or (iii) CO—R8 or COOR8 or CONHR8 or S02R8 wherein R8 may be R6 is selected from i) hydrogen, a halogen (selected from F, Cl, Br or I), or ii) an alkyl (iii) an aryl (iv) a heteroaryl (v) an O-aryl (vi) trifluoromethyl, O-alkyl (vii) NHCO—R or NHCOO—R or NHCONH—R or NHS02-R or NHS02NH—R or CO—R or COO—R or CONH—R or S02-R or SO2NH—R wherein R corresponds to hydrogen, alkyl R7 is selected from: (iv) a heteroaryl X is: —NR9R10, wherein R9 and/or R10 are hydrogen or: —CO—NR9R10, wherein R9 and/or R10 are hydrogen or: