Patent ID: 7776344
Filing Date: 2010-08-17
Classification: A61K,A61P,C12N

Abstract:
1. A chimeric nucleic acid comprising at least two immunostimulatory nucleic acids selected from the group consisting of CpG nucleic acids, T-rich nucleic acids, and poly-G nucleic acids, wherein at least one of the at least two immunostimulatory nucleic acids induces production of interferon alpha (IFN-α) from human peripheral blood mononuclear cells and has the sequence set forth by ggGGGACGATCGTCgggggG (SEQ ID NO:7), wherein each lower case letter represents phosphorothioate linkage and each upper case letter indicates a phosphodiester linkage, and wherein at least one immunostimulatory nucleic acid is an oligonucleotide comprising a diol at either or both termini.