Patent ID: 7604991
Filing Date: 2009-10-20
Classification: A61K,A61P,C12N

Abstract:
1. An In vitro method of generating insulin producing beta cells from a population comprising dedifferentiated exocrine pancreatic cells of a first mammal, said method comprising the steps of: a) providing a population comprising dedifferentiated exocrine pancreatic cells in a culture medium, b) adding one or more ligands of the gp130 receptor of a second mammal and adding one or more ligands of the EGF receptor of a third mammal to said culture medium, c) incubating said dedifferentiated exocrine pancreatic cells in said culture medium comprising said one or more ligands of the gp130 receptor and said one or more ligands of the EGF receptor, wherein one of said one or more ligands of the EGF receptor is EGF.