Patent ID: 6340694
Filing Date: 2002-01-22
Classification: A61P,C07D

Abstract:
A compound represented by the following formula(I): whereinY is an oxygen atom or a sulfur atom; R1 and R2, identical to or different from each other, are independently a hydrogen atom, a halogen atom, a C1-C6 lower alkyl group, a trifluoromethyl group, an alkoxy group, a hydroxy group, a nitro group, a nitrile group, or a carboxyl group; R3 is a group of a formula: S(O)nR5 wherein n is an integer of 0Ëœ2, R5 is a hydrogen atom, a C1-C6 lower alkyl group, or a group of a formula: NR6R7 wherein R6 and R7, identical to or different from each other, are Independently a hydrogen atom, or a C1-C6 lower alkyl group; and R4 is oxazolyl, benzo[b]thienyl, furanyl, thienyl, naphthyl, thiazolyl, indolyl, pyrolyl, benzofuranyl, pyrazolyl, pyrazolyl substituted with a C1-C6 lower alkyl group, indanyl, pyrazinyl, or a substituted group presented by the following structures: whereinR8 through R12, identical to or different from one another, are independently a hydrogen atom, a halogen atom, a C1-C6 lower alkyl group, a trifluoromethyl group, an alkoxy group, a hydroxy group, a hydroxyalkyl group, a nitro group, a 3,4-methylenedioxy group, a group of a formula: S(O)nR5, a group of a formula: NR6R7, a trifluoromethoxy group, a nitrile group, a carboxyl group, an acetyl group, or a formyl group wherein n, R5, R6 and R7 have the same meaning as defined by R3 above; and R13 is a hydrogen atom, a halogen atom, a C1-C6 lower alkyl group, a trifluoromethyl group, a alkoxy group, a hydroxy group, a trifluoromethoxy group, a carboxyl group, or an acetyl group; or a pharmaceutically acceptable salt thereof.