Patent ID: 8236943
Filing Date: 2012-08-07
Classification: A61K,C07D,C12N,Y10S

Abstract:
1. A nucleic acid-lipid particle comprising: (a) an siRNA that silences Apolipoprotein B (APOB) expression, wherein the siRNA consists of the following sense and antisense strand sequences: 5′-AGUGUCAUCACACUGAAUACC-3′ (SEQ ID NO:4) 3′-GUUCACAGUAGUGUGACUUAU-5′ (SEQ ID NO:11), wherein the bolded nucleotides are 2′OMe nucleotides; (b) a cationic lipid having the following structure: or salts thereof, wherein: R R R m, n and p are either the same or different and are independently either 0, 1 or 2, with the proviso that m, n, and p are not simultaneously 0; q is 0, 1, 2, 3, or 4; Y and Z are either the same or different and are independently O, S, or NH; and (c) a non-cationic lipid.