Patent ID: 6756382
Filing Date: 2004-06-29
Classification: A61K,A61P,C07D

Abstract:
A pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula (I): whereinR1 is â€”C2-4 alkyl-NR3â€”COâ€”R4 wherein R4 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, or alkyl; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -(substituted aryl); -heteroaryl; -(substituted heteroaryl); -heterocyclyl; -(substituted heterocyclyl); -alkyl-O-aryl; -alkyl â€”O-alkyl; -alkyl-O-alkenyl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R3)2; â€”COâ€”N(R3)2; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -(substituted aryl); -heteroaryl; -(substituted heteroaryl); -heterocyclyl; -(substituted heterocyclyl); â€”CO-aryl; and â€”CO-heteroaryl; each R3 is independently selected from the group consisting of hydrogen; C1-10 alkyl-heteroaryl; C1-10 alkyl-(substituted heteroaryl); C1-10 alkyl-aryl; C1-10 alkyl-(substituted aryl) and C1-10 alkyl; n is 0 to 4; and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, halogen and trifluoromethyl, wherein the substituent(s) of the substituted aryl are indenendently selected from the groun consisting of alkyl, alkoxy, alkythio, hydroxy, halogen, haloalkyl, haloalkylcarbonyl, haloalkoxy, nitro, alkylcarbonyl, alkenylcarbonyl, arylcarbonyl, heteroarvicarbonyl, aryl, arvialkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocycloalkyl, nitrile, alkoxycarbonyl, alkanoyloxy, and alkanovithi; or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.