Patent ID: 6830937
Filing Date: 2004-12-14
Classification: A61K,C07K,G01N

Abstract:
A method for producing an antibody or fragment thereof directed against a B7 antigen having SEQ ID NO. 8 or a fragment of SEQ ID NO. 8 which binds CD28, which antibody reacts with B7 on B7 positive B cells to inhibit B cell interaction with CD28, comprising:(a) immunizing an animal with the B7 antigen or the fragment thereof which binds CD28 so as to produce antibodies that react with B7 antigen or a fragment thereof which binds CD28; and (b) screening the antibodies so prepared for an antibody that reacts with the B7 antigen on B7 positive B cells and inhibits B cell interaction with CD28; thereby producing the antibody directed against the B7 antigen having SEQ ID NO. 8 or the fragment of SEQ ID NO. 8 which binds CD28, which antibody reacts with B7 on B7 positive B cells to inhibit B cell interaction with CD28.