Patent ID: 7482343
Filing Date: 2009-01-27
Classification: A61P,C07D

Abstract:
1. A method of inhibiting KSP which comprises contacting KSP in vitro with an effective amount of a compound having the structure: wherein: R R R R R R R R R a pharmaceutically acceptable salt thereof; wherein “substituted” alkyl, aryl and heteroaryl refer respectively to alkyl, aryl and heteroaryl wherein one or more hydrogen atoms are replaced by a substituent independently chosen from optionally substituted alkyl, optionally substituted alkoxy, alkylenedioxy, optionally substituted amino, optionally substituted amidino, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aryloxy, optionally substituted aralkoxy, carboxy, carboalkoxy, carboxyalkyl, carboxamido, aminocarbonyl, benzyloxycarbonylamino, cyano, acyl, halogen, hydroxy, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heteroaryloxy, optionally substituted heteroaralkoxy, nitro, sulfanyl, sulfinyl, sulfonyl, and thio.