Patent ID: 9175318
Filing Date: 2015-11-03
Classification: C12N,C12P

Abstract:
1. A transgenic oleaginous yeast that ferments at least one product, wherein the yeast comprises: (i) at least one gene encoding malonyl-CoA synthetase that has the amino acid sequence of SEQ ID NO:4, wherein said gene is operably linked to at least one regulatory sequence; and (ii) genes that encode enzymes that catalyze production of at least one polyunsaturated fatty acid, wherein said genes are selected from the group consisting of delta-4 desaturase, delta-5 desaturase, delta-6 desaturase, delta-12 desaturase, delta-15 desaturase, delta-17 desaturase, delta-9 desaturase delta-8 desaturase delta-9 elongase, C wherein the transgenic oleaginous yeast produces a reduced amount of malonates as a fermentation byproduct compared with the amount of malonates produced by a control oleaginous yeast.