Patent ID: 6350881
Filing Date: 2002-02-26
Classification: C07D

Abstract:
A process for the preparation of 5-methoxy-4-(methylthioalkyl)-1,3-bis(phenylmethyl)-2-imidazolidone having general formula (2a-d) wherein R is â€”CH2COCH2CH2CH2COOMe (2a); â€”CH2CH(OMe)2(2b); â€”CH2COOMe(2C); or â€”H(2d) which comprises reacting a reducing agent with 6-benzyl-7-methoxy-3-phenylperhydromimidazo[1,5-c][1.3]thiozol-5-one of general formula (1) in the presence of an organic solvent for a period ranging from 0.5 to 2 hrs at a temperature ranging from âˆ’78Â° C. to 80Â° C., evaporating the solvent and reacting the residue with an alkylating reagent, optionally inthe presence of a phase transfer catalyst and an inorganic base in an organic solvent for a period ranging from 10-12 hrs at room temperature, evaporating the solvent followed by purification to obtain the desired compound of general formula (2 a-d).