Patent ID: 6451851
Filing Date: 2002-09-17
Classification: A61K,A61P

Abstract:
A method of treating a patient suffering from a viral infection comprising administering to the patient a pharmaceutically effective amount of a known antivirally active agent or a therapeutically useful acid addition salt or therapeutically useful salt of said known antiviral agent together with a pharmaceutically acceptable amount of a hydroximic acid compound of formula (I), whereinR1 is a hydrogen or C1-5alkyl group; R2 represents a hydrogen, C1-5alkyl group, C3-8cycloalkyl group or phenyl group optionally substituted by a hydroxyl or phenyl group; R1 and R2 together with the adjacent nitrogen atom form a 5 to 8 membered ring optionally containing additional nitrogen, oxygen or sulfur atom(s), and said ring can be condensed with a alicyclic or heterocyclic ring, and nitrogen and/or sulfur as heteroatom(s) are optionally present in the form of an oxide or dioxide; R3 represents a hydrogen or phenyl, naphthyl or a pyridyl group optionally substituted by one or more halogen(s) or C1-4alkoxy group(s); Y represents a hydrogen, hydroxyl group, C1-24alkoxy group optionally substituted by an amino group, C1-24polyalkenyloxy group containing 1 to 6 double bond(s), C1-25alkanoyl group, C3-9alkenoyl group, or a group of formula R7â€”COOâ€” wherein R7 is a C2-30polyalkenyl group containing 1 to 6 double bond(s); X represents a halogen, amino group, or C1-4alkoxy group; or X and B together represent an oxygen atom; or X and Y together with the adjacent carbon atoms and the interjacent â€”NRâ€”Oâ€”CH2â€” group form a ring of formula (a), wherein Z represents an oxygen or nitrogen; R represents a hydrogen; or R and a together form a chemical bond; A represents a C1-4alkylene group, a chemical bond, or a group of the formula (b), â€ƒwherein R4 represents a hydrogen, C1-5alkyl group, C3-8cycloalkyl group, or phenyl group optionally substituted by halogen, C1-4alkoxy, or C1-5alkyl group; R5 represents a hydrogen, C1-4alkyl group, or phenyl group; m is 0, 1, or 2; and n is 0, 1, or 2; or a therapeutically useful acid addition salt thereof.