Patent ID: 9080206
Filing Date: 2015-07-14
Classification: C12Q,G01N

Abstract:
1. A method for diagnosing bladder or colorectal cancer, the method comprising the steps of: a) obtaining a sample comprising at least one target protein selected from the group consisting of MMP-2 and MMP-9 and at least one target nucleic acid selected from the group consisting of: FGFR3, K-ras, K-ras2, APC, DCC, TP53, PRC1, NUSAPI, CAPZ, PFKP, EVER1, FLT1, ESPL1, AKAP2, CDC45L, RAMP, SYNGR2, NDRG1, and ZNF533; b) conducting a single assay, wherein the assay measures the level detects both the of each target nucleic acid and the level of each target protein; and c) determining a cutoff level for each measured target protein and target nucleic acid by comparing the measured levels of said target protein and said target nucleic acid to reference standard values indicative of the presence of bladder or colorectal cancer and reference standard values indicative of the absence of bladder or colorectal cancer, wherein measured values of said target nucleic acid and said target protein above the determined cutoff values are indicative of the presence of bladder or colorectal cancer and measured values below the determined cutoff values are indicative of the absence of bladder or colorectal cancer, thereby diagnosing the presence or the absence of bladder or colorectal cancer based on the results of the assay.