Patent ID: 7906508
Filing Date: 2011-03-15
Classification: A61P,C07D

Abstract:
1. A 3,4-dihydrobenzoxazine compound selected from the following group or a pharmaceutically acceptable salt thereof: 1) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(4-tert-butoxy-3,5-difluorophenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 2) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(3,5-difluoro-4-isopropoxyphenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 3) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(3,5-difluoro-4-ethoxyphenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 4) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[2-(2,2-dimethylpropyloxy)pyridin-5-yl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 5) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(2-tert-butoxypyridin-5-yl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 6) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[2-(2,2,2-trifluoroethyloxy)pyridin-5-yl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 7) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(2-isobutoxypyridin-5-yl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 8) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, 9) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(2-hydroxy-2-methylpropyloxy)phenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide, and 10) (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1,1-dimethyl-2-hydroxyethyloxy)phenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide.