Patent ID: 8563771
Filing Date: 2013-10-22
Classification: A61K,C07B,C07C,G21H,Y02P

Abstract:
1. A process for producing a precursor compound for a radioactive fluorine-labeled organic compound, which comprises: a reaction step of allowing a solution containing a mixture of syn- and anti-isomers of a compound represented by the following formula (1): wherein, in formula (1), R 1 represents a protective group of a carboxyl group, and R 2 represents a protective group of an amino group, to react, in a presence of a base, with a compound which reacts with the OH group of the compound represented by the formula (1) to become a leaving group together with the oxygen atom of the OH group, wherein the compound is a straight-chain or branched-chain haloalkylsulfonic acid with 1-9 carbon atoms; and a purification step of purifying a reaction solution resulting from the reaction step to obtain a substantially single stereoisomer of a compound represented by the following formula (2): wherein, in formula (2), R 1 represents a protective group of a carboxyl group, R 2 represents a protective group of an amino group, and OR 3 represents the leaving group, wherein said purification step is conducted by a liquid-liquid extraction process.