Patent ID: 6180085
Filing Date: 2001-01-30
Classification: A61K,A61P

Abstract:
A composition comprising a cyanine dye of the formula ##STR7##wherein a.sub.1 and b.sub.1 are independently from 0 to 5; W.sup.1 and X.sup.1 are independently selected from the group consisting of --C((CH.sub.2).sub.zz OH).sub.2, C((CH.sub.2).sub.zz CO.sub.2 H).sub.2 and C ((CH.sub.2).sub.zz NR.sub.pp R.sub.pz).sub.2 ; R.sub.pp and R.sub.pz are independently consisting of --(CH.sub.2).sub.c --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.d --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.g --N(R.sup.14)--(CH.sub.2).sub.h --CO.sub.2 H and --(CH.sub.2).sub.i --N(R.sup.15)--CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.j --CH.sub.2 --CO.sub.2 H; zz is independently from 1 to 5, Q.sup.1 is a single bond or is selected from the group consisting of --O--, --S--, --Se--, and --NR.sup.13 ; Y.sup.1 and Z.sup.1 are independently selected from the group consisting of --(CH.sub.2).sub.c --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.d --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.e --NH.sub.2, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.f --CH.sub.2 --NH.sub.2, --(CH.sub.2).sub.g --N(R.sup.14)--(CH.sub.2).sub.h --CO.sub.2 H and --(CH.sub.2).sub.i --N(R.sup.15)--CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.j --CH.sub.2 --CO.sub.2 H; R.sup.1 and R.sup.13 to R.sup.15 are independently selected from the group consisting of--hydrogen, C1-C10 alkyl C1-C10 alkoxyl, --CH.sub.2 (CH.sub.2 --O--CH.sub.2).sub.c --CH.sub.2 --OH, --(CH.sub.2).sub.d --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.e --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.f --NH.sub.2 and --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.g --CH.sub.2 --NH.sub.2 ; c, e, g, h, and i are independently from 1 to 10; d, f and j are independently from 1 to 100; and R.sup.2 to R.sup.9 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, hydroxyl, C1-C10 alkoxyl, amino, C1-C10 aminoalkyl, cyano, nitro and halogen; and a pharmaceutically acceptable carrier or excipient.