Patent ID: 8933222
Filing Date: 2015-01-13
Classification: A61P,C07D

Abstract:
1. A method of synthesizing a compound of the following formula comprising coupling a compound of formula XX with an amine compound of the formula wherein R is —(CH L G G R R R R L Q G G R a) -hydrogen, b) —S(O) c) —S(O) d) —S(O) e) —C(O)R f) —CO g) —C(O)NR h) -haloalkyl, i) -cycloalkyl, j) -heterocyclyl, k) —C l) —C m) —C n) -aryl, o) -heteroaryl, p) —C q) —C r) —C s) —C t) —C(R wherein alkyl, alkenyl, alkynyl, aryl, heterocyclyl, heteroaryl, and cycloalkyl groups are optionally substituted 1-4 times with a group independently selected from R R a) -cycloalkyl, b) -cyano, c) —OR d) —NO e) -halogen, f) —S(O) g) —SR h) —S(O) i) —S(O) j) —NR k) —O(CR l) —C(O)R m) —CO n) —CO o) —OC(O)R p) —C(O)NR q) —NR r) —OC(O)NR s) —NR t) —NR u) —CF v) —OCF w) -haloalkyl, x) -haloalkoxy, y) —C z) —C aa) —C ab) —C ac) —C ad) -heteroaryl, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl, and cycloalkyl groups are optionally substituted 1-4 times with a group independently selected from R R a) -halogen, c) -amino, c) -carboxy, d) -cyano, e) —C f) —O—C g) —O—CF h) -cycloalkyl, i) —O-cycloalkyl, j) -aryl, k) —C l) -hydroxy, m) —CF n) -haloalkyl, o) -haloalkoxy, p) —O-aryl, q) -heteroaryl, r) -heteroarylene-C s) -heterocyclyl, t) —CO u) —CO v) -fused arylcycloalkyl, w) -alkynylene-heteroaryl, x) -alkylene-aryl, y) -alkynylene-aryl, z) -nitro, aa) —N(H)—C(O)—C bb) —S—C R R m is an integer from 1 to 2; n is an integer from 1 to 10; and p is an integer from 0 to 2.