Patent ID: 7968340
Filing Date: 2011-06-28
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for reducing the antigenicity, relative to wild-type AAV, of an AAV capsid, the method comprising introducing at least one modification into a structural protein of AAV, the structural protein being selected from the group consisting of AAV VP1, VP2, and VP3, wherein the modification does not induce an antibody response which would have been induced by the wild-type and wherein the modified structural protein forms capsids, and wherein the modification(s) is/are located directly adjacent to at least one amino acid in a sequence selected from the group consisting of YKQIS SQSGA (SEQ ID NO: 2), YLTLN NGSQA (SEQ ID NO: 3), YYLSR TNTPS (SEQ ID NO: 4), EEKFF PQSGV (SEQ ID NO: 5), NPVAT EQYGS (SEQ ID NO: 6, 7), LQRGN RQAAT (SEQ ID NO: 8), and NVDFT VDTNG (SEQ ID NO: 9).