Patent ID: 6222043
Filing Date: 2001-04-24
Classification: C07D

Abstract:
A method for preparing a dipeptide compound represented by the following formula (IA): ##STR25##whereinR.sub.1 represents a 5-membered or 6-membered monocyclic hydrocarbon group or heterocyclic group wherein 3 or fewer substituents other than hydrogen are present on the cyclic group;R.sub.21 and R.sub.22 each represents a hydrogen atom or a linear or branched aliphatic hydrocarbon group having 1-6 carbon atoms; andR.sub.3 represents a linear or branched aliphatic hydrocarbon group having 1-6 carbon atoms or a monovalent group comprising an aromatic monocyclic hydrocarbon group having 12 or fewer carbon atoms in total, wherein a halogen atom can be substituted on the aromatic ring of the aromatic monocyclic hydrocarbon group;comprising the steps of:(i) coupling a compound of the following formula (XA): ##STR26##wherein R.sub.21, R.sub.22 and R.sub.3 have the same definition as above, with a compound of the following formula (XI): ##STR27##wherein B is an amino protecting group, to produce a compound of the following formula (XIIA): ##STR28##wherein R.sub.21, R.sub.22, R.sub.3 and B have the same definition as above;(ii) deprotecting the compound having the formula (XIIA) by removing the amino protecting group;(iii) acylating the product of step (ii) with a compound having the following formula (XIII'): ##STR29##wherein R.sub.1' represents a 5-membered or 6-membered monocyclic hydrocarbon group or heterocyclic group,wherein the monocyclic group comprises a substituent which comprises a protecting group; and(iv) deprotecting the substituent on the monocyclic group by removing the protecting group to produce the dipeptide compound of the formula (IA).