Patent ID: 9018395
Filing Date: 2015-04-28
Classification: A61P,C07D,G01N

Abstract:
1. A compound of Formula IA: wherein R 1) halogen, 2) C 3) C 4) aryl, 5) heteroaryl, 6) NHR 7) C(O)NHR 8) C(O)-aryl, 9) C(O)-heteroaryl, or 10) C(O) heterocyclyl, wherein the aryl and the heteroaryl are optionally substituted with one or more R R 1) C 2) C 3) C 4) C 5) C 6) C 7) aryl C 8) C(O)NH C wherein the heterocyclyl is optionally substituted with one or more C R 1) NR 2) C(O)NR 3) C(═NH)NR 4) C(═NC 5) C(S)NR 6) CH 7) C(O)heterocyclyl optionally substituted with a C R 1) aryl, 2) heteroaryl, 3) C 4) C 5) C 6) C 7) C wherein the aryl, the heteroaryl and the heterocyclyl are optionally substituted with one or more R R 1) H, 2) C 3) C 4) heterocyclyl; R 1) CN, 2) halogen, 3) haloalkyl, 4) C 5) OC 6) O-aryl, 7) O—C 8) C(O)OC 9) C(O) C 10) C(O) aryl, 11) C(O) heteroaryl, 12) C(O)NH C 13) NHC(O) C 14) C(O)OH, 15) C(O)NH 16) NO 17) heterocyclyl, 18) C 19) heteroaryl, 20) aryl, 21) NH 22) OH, 23) CH(OH) C 24) C(OH)(C 25) C(NH 26) C(NH 27) C(NH wherein the heteroaryl is optionally substituted with aryl, C R 1) C 2) C or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof.