Patent ID: 6340701
Filing Date: 2002-01-22
Classification: A61K,A61P,C07D,C07K,Y02A

Abstract:
A compound represented by formula (I): wherein:R1 is F, NO2, CN, Cl, CHF2, CF3, â€”OCH3, â€”OCH2CH3, or NR7R8, wherein and R7 and R8 are the same or different and are linear, branched, or cyclic alkyl having 1 to 10 carbon atoms or simple or substituted aryl having 1 to 10 carbon atoms, and R1â€² and R1â€³ are H; R2 is â€”(CH2)nSZ, â€”CO(CH2)nSZ, â€”(CH2)nCH(CH3)SZ, â€”CO(CH2)nCH(CH3)SZ, â€”(CH2)nC(CH3)2SZ, â€”CO(CH2)nC(CH3)2SZ, â€”CONR12(CH2)nSZ, â€”CONR12(CH2)nCH(CH3)SZ, â€”CONR12(CH2)nC(CH3)2SZ, â€”CO-morpholino-XSZ, â€”CO-piperidino-XSZ, â€”CO-piperazino-XSZ, or â€”COâ€”N-methylpiperazino-XSZ, wherein Z is H or SR, wherein R and R12 are the same or different and are linear alkyl, branched alkyl or cyclic alkyl having from 1 to 10 carbon atoms, or simple or substituted aryl having from 1 to 10 carbon atoms or heterocyclic, and R12 in addition can be H, X is a linear alkyl or branched alkyl having from 1-10 carbon atoms, and n is an integer of 1 to 10; R3 is aryl, or is a linear, branched, or cyclic alkyl having from 1 to 10 carbon atoms; R4 is â€”OC(CH3)3 or phenyl; R5 is H; and R6 is H.