Patent ID: 6726930
Filing Date: 2004-04-27
Classification: A61K

Abstract:
A sustained release oral solid dosage form for providing an effective dose of a medicament having a solubility of less than about 10 g/l over a 24 hour period, comprisingan effective amount of a medicament to render a therapeutic effect; a gelling agent comprising xanthan gum and locust bean gum in a ratio from about 1:3 to about 3:1; a pharmaceutically acceptable cationic cross-linking agent capable of cross-linking with said gelling agent and increasing the gel strength when the dosage form is exposed to an environmental fluid; and an inert pharmaceutical diluent, the ratio of said inert diluent to the total amount of said xanthan gum and said locust bean gum being from about 1:8 to about 8:1; wherein said dosage form is a tablet.