Patent ID: 6479502
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, together with a pharmaceutically acceptable carrier wherein X represents a carboxylic acid group â€”COOH; R2 represents a radical of formula (II) â€ƒR3â€”(ALK)mâ€”(Q)pâ€”(ALK)nâ€”(II)wherein R3 represents hydrogen or an optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, or optionally substituted heterocyclic ring having 5 or 6 ring members, each ALK independently represents an optionally substituted divalent C1-C3 alkylene radical, Q represents â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O2 )â€”, â€”C(O)Oâ€”, â€”OC(O)â€”or â€”N(R9)â€”wherein R9 is hydrogen, C1-C6alkyl, or C1-C6alkoxy, and m, n and p are independently 0 or 1; R1 represents a radical of formula (II) as defined for R2, except that R1 is not hydrogen; W represents a cyclic amino radical of formula (IIIA) â€ƒand (i) R4, R5, R6 and R7 each independently represents a radical of formula (II) as defined in relation to R2, and R4a and R7a each independently represent hydrogen or C1-C3 alkyl, or (ii) R4, R4a and R5 taken together with the carbon atoms to which they are attached form an optionally substituted benzene or pyridine ring fused to the cyclic amine ring, R7a represents hydrogen or C1-C3 alkyl, and R6 and R7 each independently represents a radical of formula (II) as defined in relation to R2, or (iii) R4, R4a and R5 taken together with the carbon atoms to which they are attached form an optionally substituted benzene or pyridine ring fused to the cyclic amine ring, R6, R7 and R7a taken together with the carbon atoms to which they are attached also form an optionally substituted benzene or pyridine ring fused to the cyclic amine ring, or (iv) when W is a cyclic amino radical of formula (IIIA) wherein Y is â€”(CH(R8))â€”, then R4, R4a and R8 taken together with the carbon atoms to which they are attached form an optionally substituted benzene or pyridine ring fused to the cyclic amine ring, R7arepresents hydrogen or C1-C3 alkyl, and R5, R6 and R7 each independently represents a radical of formula (II) as defined in relation to R1 and R2, or (v) when W is a cyclic amino radical of formula (IIIB) then R4, R4a, R7 and R7a taken together with the carbon atoms to which they are attached form an optionally substituted benzene or pyridine ring fused to the cyclic amine ring, and R5 and R6 each independently represents a radical of formula (II) as defined in relation to R1 and R2, and wherein optional substituents in any of the above groups are selected from the group consisting of (C1-C3)alkyl, (C1-C3)alkoxy, oxo, phenyl, phenoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo, trifluoromethyl, cyano, nitro, â€”COOH, â€”CONH2, â€”COORA, â€”NHRA, â€”NRARB, and CONRARB, wherein RA and RB are independently (C1-C3)alkyl.