Patent ID: 6617317
Filing Date: 2003-09-09
Classification: A61K,A61P,C07F,C07K

Abstract:
A composition, which upon combination with a physiologically acceptable saline carrier forms a solution suitable for intravenous, intramuscular or subcutaneous administration to a patient, said solution comprising a compound of the formula (1a) or a pharmaceutically acceptable salt thereof; whereinP is R7â€”C(O)â€” or R7â€”SO2â€”, where R7 is pyrazinyl; X2 is â€”C(O)-NHâ€”; R is hydrogen or alkyl; R2 and R3 are independently hydrogen, alky, cycloalkyl, aryl, or â€”CH2â€”R3; R5, in each instance, is one of aryl, aralkyl, alkaryl, cycloalkyl, or â€”Wâ€”R6, where W is a chalcogen and R6 is alkyl; where the ring portion of any of said aryl, aralkyl, or alkaryl in R2, R3 and R5 can be optionally substituted by one or two substituents independently selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl, C1-6alkyl(C3-8)cycloalkyl, C2-8 alkenyl; C2-8 alkynyl, cyano, amino, C1-6 alkylamino, di(C1-6)alkylamino, benzylamino, dibenzylamino, nitro, carboxy, carbo(C1-6)-alkoxy, trifluoromethyl, halogen, C1-6 alkoxy, C6-10 aryl, C6-10 aryl(C1-6)alkyl, C6-10 aryl(C1-6)alkoxy, hydroxy, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C6-10 arylthio, C6-10 arylsulfinyl, C6-10 arylsulfonyl, C6-10 aryl, C1-6 alkyl(C6-10)aryl, and halo(C6-10)aryl; Z1 and Z2 are both hydroxy; and A is zero.