Patent ID: 6703387
Filing Date: 2004-03-09
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, lower alkyl carbonyl, aryl carbonyl, lower alkyl amino carbonyl, aryl amino carbonyl, lower alkoxy carbonyl, aryloxy carbonyl, R2a, R2b independently are H or lower alkyl or R2a and R2b together are oxo, R3a, R3b independently are H or lower alkyl, R4 and R5 together with the two carbon atoms to which they are attached form an aryl, R6 and R7 is H or lower alkyl, and R8 is aryl or a substituted or unsubstituted heterocycle selected from the group consisting of oxazolyl, isoxazolyl, furyl, tetrahydrofuryl, 1,3-dioxolanyl, dihydropyranyl, thienyl, pyrazinyl, isothiazolyl isoquinolinyl, indolyl, indazolyl, quinolinyl, dihydrooxazolyl, pyrimidinyl, benzofuranyl, tetrazolyl, pyrrolidinonyl, (N-oxide)-pyridinyl, pyrrol, triazolyl e.g. 1,2,4-triazolyl, pyrazolyl, benzotriazolyl, priperidinyl, morpholinyl, thiazolyl, pyridinyl, dihydrothiazolyl, imidazolidinyl, pyrazolinyl, benzothienyl, piperazinyl, imidazolyl, and thia diazolyl, or pharmaceutically acceptable salts thereof.