Patent ID: 8277781
Filing Date: 2012-10-02
Classification: A61J,A61K,A61M,A61P

Abstract:
1. A method for reducing ketorolac degradation under ambient conditions wherein said ketorolac is in an aqueous composition maintained in an enclosed vial having a defined gaseous headspace and containing from about 12 to 38% w/v ketorolac wherein the method comprises: a) placing said ketorolac vial on an assembly line; b) moving the vial on said assembly line wherein the vial is exposed to a flow of an inert gas directly over and into the vial to purge at least a portion of the oxygen out of the vial and subsequently capping the vial, wherein the rate of the gas flow and capping process are adjusted such that the amount of oxygen remaining in the head space of the capped vial is about 5-10% v/v; and c) capping the vial.