Patent ID: 8795684
Filing Date: 2014-08-05
Classification: A61K,A61P,C12N

Abstract:
1. A method for treating cervical dysplasia, comprising externally applying to the portio of the cervix uteri of a human patient diagnosed with or at risk of cervical dysplasia, wherein the portio of the cervix uteri is a part of the cervix projecting into an upper part of the vagina, a recombinant, genetically modified E1-deleted adenovirus comprising one or more genes encoding papillomavirus antigens, in an amount effective to treat cervical dysplasia, wherein the recombinant, genetically modified E1-deleted adenovirus is replication Defective in non-HPV infected cells and wherein the expression of HPV oncogenes E6 and E7 in HPV infected cells of the human patient results in replication of the recombinant, genetically Modified E1-deleted adenovirus.