Patent ID: 6353029
Filing Date: 2002-03-05
Classification: A61K,A61P,A61Q

Abstract:
A topical solution having long term storage stability comprising:(a) about 0.5 to about 5% w/v 4-hydroxyanisole (HA); (b) about 0.002 to about 0.05% w/v Tretinoin; (c) about 2 to about 10% v/v of a liquid low molecular weight polyethylene glycol; (d) about 0.001 to about 1.5% w/v of an antioxidant or mixture of antioxidants, the antioxidant or mixture of antioxidants being selected such that at least two of the finctions of oxygen scavaging, free radical chain terminating, and reducing, are provided; (e) about 0.001 to about 0.1% w/v of a chelating agent; (f) about 50 to about 88% v/v of a lower alkanol; and (g) water qs to 100%; said solution having a pH of about 2.5 to about 5 and a water content of at least 12% v/v.