Patent ID: 7887805
Filing Date: 2011-02-15
Classification: A61K,A61P,C07K

Abstract:
1. An antibody composition comprising at least two distinct anti-EGFR antibodies, wherein at least one of said anti-EGFR antibodies is selected from: (a) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 40) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 72) of 992, (b) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 41) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 73) of 1024, (c) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 42) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 74) of 1030, (d) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 43) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 75) of 1042, (e) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 44) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 76) of 1208, (f) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 45) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 77) of 1229, (g) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 46) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 78) of 1254, (h) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 47) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 79) of 1257, (i) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 48) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 80) of 1260, (j) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 49) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 81) of 1261, (k) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 50) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 82) of 1277, (l) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 51) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 83) of 1284, (m) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 52) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 84) of 1308, (n) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 53) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 85) of 1320, (o) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 54) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 86) of 1344, (p) an antibody comprising CDR1, CDR2, and CDR3 of the heavy chain (SEQ ID NO: 55) and CDR1, CDR2, and CDR3 of the light chain (SEQ ID NO: 87) of 1347, and (q) mixtures of two or more of said antibodies in (a)-(p).