Patent ID: 6274705
Filing Date: 2001-08-14
Classification: C07K

Abstract:
A compound which is an intermediate in the synthesis of an antithrombotic pseudopeptide, having the formula: ##STR40##wherein:B is alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, aralkyl, alkylaryl or alkylaralkyl;F' is selected from the group consisting of --H, alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, carboxymethyl, 2-carboxyethyl, aminocarbonylmethyl, 2-aminocarbonylethyl, 4-aminobutyl, 3-aminopropyl, 3-guanidinopropyl, indol-3-ylmethyl, imidazol-3-ylmethyl, cycloalkyl, cycloalkylalkyl, cyclohexylcyclohexylmethyl, 1,2,3,4-tetrahydronaphth-5-ylmethyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heterocyclyl, and substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, wherein heterocyclyl is pyridyl, pyrimidyl or pyrrolidyl;G' is alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heterocyclyl, substituted heterocyclyl, heterocyclyl-alkyl and substituted heterocyclylalkyl, wherein heterocyclyl is pyridyl, pyrimidyl or pyrrolidyl,p is 1 to 4, andP.sub.2 is a carboxylic acid protecting group and P.sub.3 is an amino protecting group.