Patent ID: 6266622
Filing Date: 2001-07-24
Classification: A61K,A61P,C07K,G01N,G16B

Abstract:
A method for identifying a compound capable of selectively modulating the activity of a thyroid hormone receptor (TR) isoform, said method comprising:modeling test compounds that fit spatially and preferentially into a TR ligand binding domain (TR LBD) isoform of interest using an atomic structural model of a TR LBD isoform bound to a test compound, wherein said atomic structural model is generated utilizing data from Appendix 3, 4, 5, 6, 7 or 8,screening said test compounds in a biological assay for TR isoform activity characterized by binding of a test compound to a TR LBD isoform, andidentifying a test compound that selectively modulates the activity of a TR isoform.