Patent ID: 6319902
Filing Date: 2001-11-20
Classification: A61K,C07K

Abstract:
A peptide derivative of the formula (I): ##STR95##whereinA is 4-thiazolyl or 5-thiazolyl wherein the nitrogen in the thiazolyl ring may be a quarternary nitrogen which is formed with an optionally substituted alkyl or alkenyl group,X is a bond, oxygen, or sulfur,m is an integer of 0 to 4,Y is an optionally substituted alkyl, an optionally substituted carboxy, a cyano, or a substituent represented by the formula: ##STR96##wherein R.sup.1 and R.sup.2 are independently a hydrogen or an optionally substituted alkyl group, or R.sup.1 and R.sub.2 taken together with may form a non-aromatic heterocyclic ring with the adjacent nitrogen, which may contain oxygen, nitrogen, or sulfur and may be substituted,Z is the substituent represented by the formula: ##STR97##wherein R.sup.3 is a hydrogen, an optionally substituted alkyl group, an optionally substituted carboxy group, or an optionally substituted acyl group, R.sup.4 and R.sub.5 are each independently a hydrogen or an optionally substituted alkyl group, and W is an oxygen, a sulfur, an optionally substituted imino, --(CH.sub.2)n- wherein n is 0, 1, 2, or 3, or the substituent represented by the formula: ##STR98##or an acceptable salt or hydrate thereof.