Patent ID: 6667401
Filing Date: 2003-12-23
Classification: C07D

Abstract:
A process for the preparation of compounds of the formula (I) wherein R1 represents a hydrogen atom, A represents an ethylene group which may be substituted by alkyl, or a trimethylene group which may be substituted by alkyl, D represents nitro or cyano, X represents an oxygen or sulphur atom or the groups â€ƒwherein R3 represents a hydrogen atom or an alkyl group, and Z represents 2-chloropyrid-5-yl, said process comprising (a) reacting with a base, in the presence of a diluent, a compound of the formula (II) â€ƒwherein A, D and X are as defined above, to yield a reaction mixture (b) reacting said reaction mixture with a mixture of CCMP/CMP (2-chloro-5-chloromethylpyridine/2-chloro-5-methylpyridine) with the corresponding hydrochlorides; and (c) collecting the reaction product.