Patent ID: 6825199
Filing Date: 2004-11-30
Classification: C07D

Abstract:
A compound of Formula I or a pharmaceutically acceptable salt thereof wherein:R1 is H, a straight or branched alkyl of 1 to 6 carbons, cycloalkyl of 3 to 6 carbons, a heterocycle of 4 to 6 atoms having 1 to 2 heteroatoms, or a phenyl group, each is optionally substituted by R, F, Cl, OR, or N(R)2 wherein R is H, a straight or branched alkyl of 1 to 6 atoms having 0 to 1 degrees of unsaturation, a ring of 3 to 6 atoms having 0 to 2 heteroatoms, or a phenyl group, each may be substituted by F, Cl, CN, NO2, OH, NH2; also, two R's may form a 3- to 7-membered ring with the atom to which it is attached which ring may have 0 to 1 heteroatoms; R5 and R6 are each independently H, F, Cl, Br, NO2, CN, CF3, (C(R)2)nOR, (C(R)2)nCO2R, (C(R)2)nCON(R)2, (C(R)2)nN(R)2, (C(R)2)nNRCOR, a straight or branched alkyl of 1 to 4 carbons containing 0 to 1 degrees of unsaturation, a cycloalkyl of 3 to 6 carbons, each optionally substituted by F, Cl, OR, or N(R)2 wherein R is as defined above; R7 is selected from F, Cl, Br, NO2, CN, CF3, (C(R)2)nOR, (C(R)2)nCO2R, (C(R)2)nCON(R)2, (C(R)2)nN(R)2, (C(R)2)nNRCOR, a straight or branched alkyl of 1 to 4 carbons containing 0 to 1 degrees of unsaturation, a cycloalkyl of 3 to 6 carbons, each optionally substituted by F, Cl, OR, or N(R)2 wherein R is as defined above, a phenyl, or a heterocyclic ring of 4 to 7 atoms, a fused heterocyclic ring of 8 to 10 atoms, a bicyclic heterocycle of 6 to 9 atoms, or a spiro heterocycle of 7 to 12 atoms each having 1 to 4 heteroatoms, and each of which is optionally substituted by one or more of R, F, Cl, (C(R)2)nN(R)2, (C(R)2)nOR, O, (C(R)2)nCON(R)2, (C(R)2)nCOR, (C(R)2)nNRCOR, (C(R)2)nCO2R, wherein R is defined above; any of the adjacent groups R5-R8 may together form a 5- to 7-membered ring having 0 to 2 heteroatoms, which rings may be substituted by any of the groups described for R7; and n is an integer of from 0 to 3.