Patent ID: 6340459
Filing Date: 2002-01-22
Classification: A61K,A61P,C07K,G01N,Y02A

Abstract:
A method for treating reperfusion injury in a subject other than a graft recipient, by inhibiting activation of cells bearing CD40 on their surface, other than B cells, comprising the step of administering to said subject an antibody, Fab, F(abâ€²)2 or a single chain antibody, which binds specifically to an antigen specifically bound by monoclonal antibody 5c8, produced by the hybridoma having ATCC Accession No. HB 10916, wherein said antibody, Fab, F(abâ€²)2 or single chain antibody, inhibits binding between CD40 ligand and CD40 on the surface of said cells, wherein said antibody, Fab, F(abâ€²)2 or single chain antibody, is effective to inhibit transmigration of inflammatory cells across the barrier of endothelial cells in said subject .