Patent ID: 7262206
Filing Date: 2007-08-28
Classification: A61P,C07D

Abstract:
1. Compounds of general formula wherein R an aryl group optionally substituted by a fluorine, chlorine or bromine atom, R a 5- or 6-membered heteroaryl group with one to three heteroatoms selected from the group N, S and O, optionally substituted by one or two fluorine, chlorine, bromine or iodine atoms or one or two nitro, cyano, amino, C a phenyl group wherein two adjacent carbon atoms are linked together through a methylenedioxy, ethylenedioxy or difluoromethylenedioxy group, a phenyl group, to which another phenyl ring or a 5- or 6-membered heteroaromatic ring with one to three heteroatoms selected from the group N, S and O, wherein the heteratoms may be identical or different, is anellated, while the bicyclic group may be substituted by one or two fluorine, chlorine, bromine or iodine atoms or one or two nitro, cyano, amino, C a phenyl group which may be substituted by one to three fluorine, chlorine, bromine or iodine atoms or by one to three C R a cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, cyclopentenyl or cyclopentyl group which is substituted by a hydroxy, C a cyclopentyl or cyclohexyl group wherein the methylene group in position 3 or 4 is replaced in each case by an oxygen or a sulphur atom, a sulphonyl group or a sulphinyl group, a cyclohexyl group which is substituted by a C a 5- to 7-membered cycloalkyleneimino group wherein the methylene group in the 4 position may be replaced by an oxygen or a sulphur atom, a sulphonyl group or a sulphinyl group, a piperidin-4-yl, piperidin-3-yl, homopiperidin-4-yl or pyrrolidin-3-yl group which may be substituted at the amino-nitrogen atom by a straight-chain or branched C a piperidin-4-yl group which is substituted in the carbon skeleton by one to four C a piperidin-1-yl group which may be substituted in the carbon skeleton by one to four C a piperazinyl group which may be substituted in the 4 position by a C a 6-methyl-6-aza-bicyclo[3.1.1]heptanyl or 8-methyl-8-aza-bicyclo[3.2.1.]octanyl group, while the above-mentioned alkyl groups may be straight-chain or branched, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof.