Patent ID: 7211271
Filing Date: 2007-05-01
Classification: A61F,A61L,Y10S

Abstract:
1. A method of increasing the affinity of a hydroxyapatite component of a biomedical implant for native bone or tissue, said method comprising the following steps in any order: (a) nitriding the surface and a region adjacent to the surface of said hydroxyapatite component to about 1% to about 4% by weight nitridation by contacting said hydroxyapatite with a member selected from the group consisting of ammonia and ionized molecular nitrogen, and (b) after step (a), treating the surface of said hydroxyapatite component with a protein selected from the group consisting of BMP 2, BMP 3, BMP 4, BMP 5, BMP 6, and BMP 7.