Patent ID: 6281238
Filing Date: 2001-08-28
Classification: C07D

Abstract:
A compound of formula I having the structure ##STR8##whereinB and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon atoms;R.sup.1 is --CH(R.sup.2)W, or 5-thiazolidine-2,4-dione;--CH(R.sup.2)W represents a moiety wherein either:1) R.sup.2 is selected from --CH.sub.2 (1H-imidazol-4-yl), --CH.sub.2 (3-1H-indolyl), --CH.sub.2 CH.sub.2 (1,3-dioxo-1,3-dihydro-isoindol-2-yl), or --CH.sub.2 CH.sub.2 (1-oxo-1,3-dihydro-isoindol-2-yl) and W is selected from --CO.sub.2 R.sup.3, --CONH.sub.2, --CONHOH, --CN, CONH(CH.sub.2).sub.2 CN, 5-tetrazole, or --PO.sub.3 (R.sup.3).sub.2 ; or2) R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, or aryl and W is 5-tetrazole;R.sup.3 is hydrogen, alkyl of 1-6 carbon atoms, or aryl;or a pharmaceutically acceptable salt thereof.