Patent ID: 6153405
Filing Date: 2000-11-28
Classification: A21D,A23L,A61K,A61P,C07K

Abstract:
A polynucleic acid which, in a subtilin-producing or nisin-producing host, encodes a prepeptide of the formula:(leader)-(lantibiotic)where the leader is selected from the group consisting of a subtilin leader sequence, a nisin leader sequence, and chimeras of said subtilin leader sequence and said nisin leader sequence which permit production of an active lantibiotic in a lantibiotic-producing host; andthe lantibiotic is a chimeric lantibiotic having the formula: ##STR2## where Xaa is any amino acid, including a dehydro amino acid residue or one of the two residues of a lanthio amino acid, and Z is Sub.sub.13-32, with the proviso that simultaneously, the 1-position is not Trp, the 2-position is not Lys, the 4-position is not Ile, and the 5-position is not Dha or Ala.