Patent ID: 6306852
Filing Date: 2001-10-23
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR155##whereinR.sup.1 and R.sup.2 are optional substituents and independently represent C.sub.1-6 alkyl, C.sub.2-6 alkenyl C.sub.2-6 alkynyl, halogen C.sub.1-3 perfluoroalkyl, (CH.sub.2).sub.m Ar.sup.1. (CH.sub.2).sub.m Her.sup.1, (CH.sub.2).sub.m CONR.sup.7 R.sup.8, (CH.sub.2).sub.m CO.sub.2 R.sup.8, O(CH.sub.2).sub.q CO.sub.2 R.sup.8, (CH.sub.2).sub.m COR.sup.8. (CH.sub.2).sub.m OR.sup.8. O(CH.sub.2).sub.p OR.sup.8. (CH.sub.2).sub.m NR.sup.7 R.sup.8, CO.sub.2 (CH.sub.2).sub.q NR.sup.7 R.sup.8, (CH.sub.2).sub.m CN, S(O).sub.n R.sup.8, SO.sub.2 NR.sup.7 R.sup.8, CONH(CH.sub.2).sub.m Ar.sup.1 or CONH(CH.sub.2).sub.m Her.sup.1 ;R.sup.3 represents H, C.sub.1-6 alkyl, (CH.sub.2).sub.p NR.sup.9 R.sup.10, SO.sub.2 R.sup.10, SO.sub.2 NR.sup.9 R.sup.10, (CH.sub.2).sub.m COR.sup.10, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, (CH.sub.2).sub.m CONR.sup.9 R.sup.10, (CH.sub.2).sub.m CO.sub.2 R.sup.10, (CH.sub.2).sub.p CN, (CH.sub.2).sub.p R.sup.10 or (CH.sub.2).sub.p OR.sup.10 ;R.sup.4 and R.sup.9 independently represent H or C.sub.1-6 alkyl;R.sup.7 represents H, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;R.sup.5 represents H or OH;R.sup.6 represents methylenedioxyphenyl, alkoxy and halogen,R.sup.8 and R.sup.10 independently represent H, C.sub.1-6 alkyl, Ar.sup.2 , Het.sup.2 or C.sub.1-6 alkyl substituted by Ar.sup.2 or Het.sup.2 ;Z represents CO.sub.2 H, COHN(tetrazol-5-yl), CONHSO.sub.2 O(C.sub.1-4 alkyl), CO.sub.2 Ar.sup.3, CO.sub.2 (C.sub.1-6 alkyl), tetrazol-5-yl, CONHSO.sub.2 Ar.sup.3. CONHSO.sub.2 (CH.sub.2).sub.q Ar.sup.3 or CONHSO.sub.2 (C.sub.1-6 alkyl);m represents 0, 1, 2 or 3;n represents 0, 1 or 2;p represents 2, 3 or 4;q represents 1, 2 or 3;Ar.sup.1-3 independently represent phenyl, naphthyl, or an aromatic heterocycle having 5 ring members 2 to 4 which are selected from N, S and O, which aromatic heterocycle is optionally fused to a benzene ring, and which phenyl group is optionally fused to an aromatic heterocycle as defined immediately above, the group as a whole being optionally substituted by one or more groups falling within the definition of R.sup.1 above; andHet.sup.1 and Het.sup.2 independently represent a non-aromatic heterocycle having 5 ring members 2 to 4 of which are selected from N, S and O, which group is optionally substituted by one or more groups falling within the definition of R.sup.1 above, and is further optionally substituted by .dbd.O or .dbd.S;or a pharmaceutically acceptable salt thereof.