Patent ID: 8815803
Filing Date: 2014-08-26
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method for increasing the body height of an individual free from fibroblast growth factor receptor 3 (FGFR3) abnormality, comprising administering systemically C-type natriuretic peptide (CNP) or a derivative thereof to increase the body height in the individual, wherein the individual has growth cartilage layers, wherein the CNP is CNP-53 of SEQ ID NO: 2, wherein the derivative is selected from the group consisting of: CNP derivatives which are obtained from the amino acid sequence of SEQ ID NO: 2 by replacing all of residues 32-53 of SEQ ID NO:2 with a sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs: 3 to 10, wherein the CNP derivatives possess a CNP activity.