Patent ID: 6365172
Filing Date: 2002-04-02
Classification: A61L,C08G,Y10T

Abstract:
A self-reinforced bioabsorbable device comprised of fused or sintered fibers made from a bioabsorbable polymer comprising a poly(ester-amide) of the general formula (I): wherein, x is from 2 to 10, m and n are independently from 0 to 2000, p is from 10 to 2000, and A is comprised of from 0 to 90 mole % A1 in combination with other structures selected from the group consisting of A2 and A3, wherein:A1 is defined by formula (II): â€”(CH2)yâ€”, wherein y is from 2 to 10; A2 is defined by formula (III): wherein:R1 is selected from the group consisting of: i) a linear alkene having from 1 to 5 carbon atoms; ii) an ester defined by formula(IV): â€”(CH2)x1â€”Oâ€”(CH2)y1â€”, wherein the â€”(CH2)x1 end of the ester is attached to the amide carbonyl of formula (III), x1 is from 1 to 4 and y1 is independently from 2 to 6; iii) a benzyl alkane of formula(V): â€”(CH2)x2â€”C6H4â€” wherein the â€”(CH2)x2 end of the benzyl alkane is covalently attached to the amide carbonyl of formula III, and x2 is from 0 to 1; and iv) an alkyl benzyl ether of formula(VI): â€”(CH2)x3â€”C6H4â€”Oâ€”(CH2)y3â€”, wherein the â€”(CH2)x3 end of the alkyl benzyl ester is attached to the amide carbonyl of formula III, x3 is from 0 to 1, the (CH2)y3â€” end of the alkyl benzyl ester is attached to the ester oxygen of formula I, and y3 is independently from 2 to 6; and R2 is selected from the group consisting of linear alkylenes having from 2 to 10 carbon atoms; and A3 is defined by formula (VI): wherein R3 is a divalent aliphatic or aromatic hydrocarbon radical having from 3 to about 8 carbon atoms; andE2 is defined by a formula selected from the group of formulae consisting of: formula (VII): [â€”COâ€”CHR4â€”Oâ€”], wherein R4 is selected from the group consisting of â€”H (from glycolide) and â€”CH3 (from lactide); formula (VIII): [â€”COâ€”Oâ€”(CH2)3â€”Oâ€”]; formula (IX): [â€”COâ€”CH2â€”Oâ€”(CH2)2â€”Oâ€”]; formula (X): [â€”COâ€”(CH2)5â€”Oâ€”]; and combinations of formula VII to X; and E1 has the same structure as E2 cxcept that the orientation of the formula of E1 is reversed.