Patent ID: 6495719
Filing Date: 2002-12-17
Classification: A61K,C07C,C07D

Abstract:
A compound of formula (I): whereinA is a cyclic moiety selected from the group consisting of C3-14 cycloalkyl, 3-14 membered heterocycloalkyl, C4-14 cycloalkenyl, 3-14 membered heterocycloalkenyl, monocyclic aryl, or monocyclic heteroaryl; the cyclic moiety being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxylalkyl, halo, haloalkyl, amino, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylsulfonylamino, aminosulfonyl, or alkylsulfonyl; each of X1 and X2, independently, is O or S; Y1 is â€”CH2â€”, â€”Oâ€”, â€”Sâ€”, â€”N(Ra)â€”, â€”N(Ra)â€”C(O)â€”Oâ€”, Oâ€”C(O)â€”N(Ra)â€”, â€”N(Ra)â€”C(O)â€”N(Rb)â€”, â€”C(O)â€”Oâ€”, â€”Oâ€”C(O)â€”Oâ€”, or a bond; each of Ra and Rb, independently, being hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, or haloalkyl; Y2 is â€”CH2â€”; L is an unsaturated straight C4-10 hydrocarbon chain containing at least two conjugated double bonds, at least one triple bond, or at least one double bond and one triple bond; said unsaturated hydrocarbon chain being optionally substituted with C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, hydroxyl, halo, carboxyl, amino, nitro, cyano, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl, unsubstituted monocyclic aryl, 5-6 membered heteroaryl, C1-4 alkylcarbonyloxy, C1-4 alkyloxycarbonyl, C1-4 alkylcarbonyl, or formyl; R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, haloalkyl, or an amino protecting group; and R2 is hydrogen, alkyl, hydroxylalkyl, haloalkyl, or a hydroxyl protecting group; or a salt thereof.