Patent ID: 6210938
Filing Date: 2001-04-03
Classification: A61P,C07B,C07D,C12N,C12P

Abstract:
An improved process for catalyzing an aldol reaction between aldehyde and ketone reactants, wherein the improvement comprises contacting said aldehyde and ketone reactants with antibody molecules or molecules containing antibody combining site portions that catalyze an aldol addition reaction produced according to the following method:Step A: eliciting an aldolase immune response within an immune response subject by vaccination with a sterile solution containing the appropriate concentration of an aldol transition state immunoconjugate, said aldol transition state immunoconjugate including a sulfone .beta.-diketone hapten; thenStep B: isolating and cloning an antibody producing cell from the immune responsive subject of said Step A which expresses a catalytic aldolase antibody; and thenStep C: isolating the catalytic aldolase antibody expressed by the antibody producing cell isolated and cloned in said Step B.