Patent ID: 6608067
Filing Date: 2003-08-19
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula (I): wherein:W is: â€ƒwherein: m is 0 or 1; each R2 is H; J is selected from t-butyl, methyl, trifluoromethyl, hydroxy, methoxy, ethoxy, trifluoromethoxy, carboxy, phenyl, benzyl, phenoxy, benzyloxy, fluoro, chloro, bromo, isoxazolyl, pyridinyl, piperidinyl, carboxymethyl, carboxyethyl, dialkylamino, morpholinylmethyl, phenylacetylamino, or acylamino, wherein each J is optionally substituted with 1-3 J1 groups; each J1 is independently selected from C1-3 alkoxy, chloro, C1-3 alkyl, or phenyl; L is CH2CH3 or CH2CF3; each M is independently selected from isopropyl, propyl, methyl, pyridylmethyl, benzyl, naphthylmethyl, phenyl, imidazolylmethyl, thiophenylmethyl, cyclohexylmethyl, phenethyl, benzylthiomethyl, or benzyloxyethyl; R18 is â€”N(R11)â€”; R11 is hydrogen or C1-C3 alkyl; one R19 is â€”Oâ€”(C1-C3)-alkyl-aryl and the other two R19 are H; or two adjacent R19 are bound together to form phenyl ring and the other R19 is H; n is 1; the ring to which R18 and R19 are attached is phenyl; A2 is a bond or â€”N(R11)â€”C(H)(M)â€”C(O)â€”; V is â€”N(R11)â€”; K is â€”C(O)â€”; and T is â€”R12 or -alkyl-R12; wherein: each R12 is independently aryl or heteroaryl and is optionally substituted with 1 to 3 J groups.