Patent ID: 6211225
Filing Date: 2001-04-03
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR33##whereinthe wavy bond {character pullout} represents the racemate, the (R)-enantiomer or the (S)-enantiomer;R.sup.1 and R.sup.2 each are independently hydrogen or halogen;W is CR.sup.5, CR.sup.5 R.sup.6 or (CH.sub.2)n, with n=1-2;Z is CH.sub.2, CH or oxygen;R.sup.3 is hydrogen or C.sub.1-4 alkyl;R.sup.4 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-3 haloalkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkyamino, C.sub.3-6 cycloalkylamino, di(C.sub.1-4)alkylamino, C.sub.1-4 alkoxy (C.sub.1-4)alkyl, C.sub.1-4 alkylthio(C.sub.1-4)alkyl or C.sub.1-4 trifluoromethyl(C.sub.1-2)alkyl; andR.sup.5 and R.sup.6 each are independently hydrogen or C.sub.1-4 alkyl; or a nontoxic pharmaceutically acceptable salt, hydrate or solvate thereof.