Patent ID: 6696455
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound, and pharmaceutically acceptable salts thereof, having the formula: wherein X and Y may be the same or different and are selected from the group consisting of OH, NH2, H and CH3; wherein Z and Z1 are different and are selected from the group consisting of â€ƒwhere Z is R4 when â€ƒwhen Z1 is R4; wherein A is selected from the group consisting of nitrogen, carbon, sulfur, absent and a bond; wherein B is selected from the group consisting of sulfur, sulfoxide, sulfone, CH, oxygen, nitrogen and a bond, but B is not sulfur, sulfoxide, sulfone, oxygen or nitrogen when A is sulfur; wherein R1 is selected from the group consisting of hydrogen, a nitroso group, an aldehyde, a lower alkyl group, a formyl group and absent, and R1 is absent when B is a bond, oxygen, sulfur, sulfoxide or sulfone; wherein R2 is selected from the group consisting of an aryl group, an alkylaryl group, a substituted aryl group, a substituted alkylaryl group, a diaryl group, a triaryl group, an aklyldiaryl group, an alicyclic hydrocarbon group, an alkyltriaryl group, a substituted diaryl group and a substituted tiaryl group, and each substituent of the substituted aryl group, diaryl group, and triaryl group is the same or different and is selected from the group consisting of a lower alkyl group, an alkoxy, a substituted alkoxyaryloxy group, and absent; wherein R3 is selected from the group consisting of H, a lower alkyl and absent, and R3 is absent when A is absent or a bond; wherein R4 is selected from the group consisting of hydrogen and a lower alkyl; but R2 is not 2,5-dimethoxyphenyl when X is NH2, Y is NH2, Z1 is H, B is CH, and R1 is H; and wherein each lower alkyl group is independently selected from the group consisting of lower alkyl groups having from about 1 to 6 carbons.