Patent ID: 8263753
Filing Date: 2012-09-11
Classification: A61P,C07H

Abstract:
1. A process for making a macrolide or a salt thereof, wherein: the macrolide corresponds in structure to Formula (I): the process comprises: wherein the piperidinyl compound of Formula (II) corresponds in structure to: the 20-piperidinyl-tylosin compound corresponds in structure to Formula (III): the 23-O-mycinosyl-20-piperidinyl-5-O-mycaminosyl-tylonolide compound corresponds in structure to Formula (IV): the 23-hydroxyl-20-piperidinyl-5-O-mycaminosyl-tylonolide compound corresponds in structure to Formula (V): the activated compound corresponds in structure to Formula (VI): the piperidinyl compound of Formula (VII) corresponds in structure to: L is a leaving group; and as to R as to R