Patent ID: 6013492
Filing Date: 2000-01-11
Classification: C12P

Abstract:
A process for producing calcium D-pantothenate, comprising:removing insoluble solids from a fermentation broth of D-pantothenic acid directly produced by microbial fermentation;decolorizing the fermentation broth with activated carbon to obtain a solution containing D-pantothenic acid;adjusting the pH of the solution containing D-pantothenic acid to 1 to 5;bringing the solution containing D-pantothenic acid into contact with granular activated carbon to which saccharides have lower adsorbability than D-pantothenic acid and which is packed in at least two columns connected in series continuously to adsorb the D-pantothenic acid to the activated carbon until the saturated adsorption point;eluting the D-pantothenic acid with a hydrophilic organic solvent;neutralizing the eluate with an alkali agent containing calcium to precipitate calcium D-pantothenate; andcollecting the calcium D-pantothenate.