Patent ID: 6103704
Filing Date: 2000-08-15
Classification: A61K

Abstract:
A method of accumulating a drug and a form of hyaluronic acid in the skin or exposed tissue of a human, for treatment of a disease or condition of the skin or exposed tissue selected from the group consisting of basal cell carcinoma, actinic keratosis lesions, fungal lesions, ""liver"" spots, squamous cell tumors, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, malignancies and tumors in the skin, genital warts, cervical cancer, HPV (Human Papilloma Virus) infection, psoriasis, corns on the feet, and hair loss on the head of pregnant women, comprising topically administering a composition comprising (a) between about 52.2% and about 95.5% by weight of water; (b) an effective non-toxic dosage amount between about 1% and about 5% by weight of a drug selected from the group consisting of a non-steroidal anti-inflammatory drug and an anti-cancer drug; and (c) between about 1% and about 3% by weight, and at least 5 mg per square centimeter of skin or exposed tissue, of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof, wherein the form of hyaluronic acid has a molecular weight between 150,000 and 750,000 daltons, and wherein the form of hyaluronic acid is effective to transport the drug through the skin or exposed tissue where the drug and the form of hyaluronic acid accumulate and remain until discharged through the lymphatic system.