Patent ID: 6531573
Filing Date: 2003-03-11
Classification: A61K,C07K

Abstract:
A substantially pure peptide containing between 13 and 20 amino acids, inclusive, wherein the peptide has the amino acid sequence:R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-R15-R16-R17-R18-R19-R20-R21-R22-R23 whereinR1 is Asp or is absent; R2 is Ser or is absent; R3 is His or is absent; R4 is Ala; R5 is Lys, Gln, Arg, or another basic amino acid; R6 is Arg, Gin, Lys, or another basic amino acid; R7 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R8 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R9 is Gly, Lys, Arg, or another basic amino acid; R10 is Tyr; R11 is Lys, His, Phe, or another hydrophobic amino acid; R12 is Arg, Gln, Lys, or another basic amino acid; R13 is Lys, Gln, Arg, another basic amino acid, or is absent; R14 is Phe or is absent; R15 is His, Phe, Tyr, Leu, another hydrophobic amino acid, or is absent; R16 is Glu or is absent; R17 is Lys or is absent; R18 is His or is absent; R19 is His or is absent; R20 is Ser or is absent; R21 is His or is absent; R22 is Arg or is absent; R23 is Gly or is absent; wherein Gln cannot simultaneously occupy positions R5, R6, R12, and R13 of the amino acid sequence, and wherein when R5, R6, R7, R8, R9, R12, R13 and R15 simultaneously are Lys, Arg, His, His, Gly, Arg, Lys and His, respectively, then R11 is His, Phe or another hydrophobic amino acid other than Lys.