Patent ID: 9163062
Filing Date: 2015-10-20
Classification: A61K,A61P,C07K

Abstract:
1. A method for inducing in a subject antibodies specific to Amyloid β(1-40) or antibodies specific to Amyloid β(1-42) comprising administering to said subject an effective amount of a conjugate consisting of: a) a bovine serum albumin (BSA) directly connected to b) one or more than one linker region, each linker region directly connected to c) only one cysteine, wherein the cysteine is directly connected to d) the N-terminus of a single Amyloid β(35-42) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 2, the N-terminus of a single Amyloid β(33-42) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 3, or the N-terminus of a single Amyloid β(33-40) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 4, wherein in said conjugate, said single Amyloid β peptide is connected through the one cysteine to said one linker region wherein said linker region is between said one cysteine and said BSA, and said conjugate terminates at the carboxy-terminus of the Amyloid β(35-42) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 2, the Amyloid β(33-42) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 3, or the Amyloid β(33-40) peptide consisting of the amino acid sequence set forth in SEQ ID NO: 4, wherein said effective amount of the conjugate is effective to induce in the subject antibodies specific to Amyloid β(1-40) or antibodies specific to Amyloid β(1-42).