Patent ID: 8450062
Filing Date: 2013-05-28
Classification: A61P,C12Q,G01N

Abstract:
1. A method of detecting lung cancer, breast cancer, or mesothelioma in a patient, the method comprising: determining the amount of methylation of the CpG residues occurring within the region from −1005 to −983 or from −754 to −737 of a SOCS-3 promoter comprising SEQ ID NO: 3 in a biological sample from the patient, wherein said biological sample is a sample of lung tissue, breast tissue or mesothelium; and determining that lung cancer, breast cancer, or mesothelioma is present in the patient when the amount of methylation of the SOCS-3 promoter in the biological sample is elevated relative to the amount of methylation of the SOCS-3 promoter in a sample of normal lung tissue, breast tissue or mesothelium, respectively, thereby detecting the presence of lung cancer, breast cancer, or mesothelioma in the patient.