Patent ID: 6875741
Filing Date: 2005-04-05
Classification: A61P,C07K

Abstract:
1. A method of decreasing insulin receptor activity in mammalian cells comprising administering to said cells an amino acid sequence in an amount sufficient to decrease insulin activity, wherein the amino acid sequence comprises a subsequence that binds to Site 1 of insulin receptor and a subsequence that binds to Site 2 of insulin receptor, wherein the Site 1 sequence consists essentially of a Formula 1 sequence X 1 X 2 X 3 X 4 X 5 and the Site 2 sequence consists essentially of a Formula 6 sequence X 62 X 63 X 64 X 65 X 66 X 67 X 68 X 69 X 70 X 71 X 72 X 73 X 74 X 75 X 76 X 77 X 78 X 79 X 80 X 81 , wherein X X X X X X the subsequences are linked C-terminus to N-terminus; and the subsequences are oriented Site 2 to Site 1, with the proviso that the amino acid sequence is not insulin, insulin-like growth factor, or fragments thereof.