Patent ID: 8663696
Filing Date: 2014-03-04
Classification: A61K,A61P

Abstract:
1. A pharmaceutical-based film composition, comprising pharmaceutically active agent tetrahydrolipstatin in a stable, small-scale form and at least one water soluble polymer, wherein said film composition is formed by a method comprising the steps of: a. providing a mixture of said pharmaceutically active agent having a melting point less than or equal to about 100° C. and at least one water soluble polymer; b. adding at least a portion of said mixture to a solvent, said solvent being heated to a temperature above said melting point of said pharmaceutically active agent whereby said active agent melts and forms a liquid dispersion of the active agent in the mixture; and c. rapidly evaporating the solvent to form a solid matrix containing a stabilized solid dispersion of said pharmaceutically active agent in said solid matrix, wherein said pharmaceutically active agent is present in the form of nanoparticles, microparticles, or combinations thereof.