Patent ID: 7968328
Filing Date: 2011-06-28
Classification: C07B,C07C,Y02P

Abstract:
1. A process for preparing optically active compounds of formulae I-S and/or I-R wherein n is 0, 1, or 2; and m is 0, 1, or 2; comprising (i) reacting an enantiomer mixture of compounds of formula II (ii) removing the unacylated enantiomer of compound (II) from the mixture obtained in step (i); (iii) deprotecting the unacylated enantiomer of compound (II) obtained in step (ii) to give the amine (I-S) or (I-R); and (iv) if desired hydrolyzing the essentially acylated enantiomer of compound (II) obtained in step (i) to give the corresponding unacylated enantiomer of the amine (II) and subsequently deprotecting it to give the amine (I-R) or (I-S).