Patent ID: 8552156
Filing Date: 2013-10-08
Classification: A61P,C07K,G01N

Abstract:
1. A monoclonal antibody or an antigen-binding fragment thereof, which is one selected from the following (a) to (e): (a) a monoclonal antibody or an antigen-binding fragment thereof, each comprising a heavy chain (H chain) and a light chain (L chain), wherein complementarity determining regions (CDRs) 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 1 to 3, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 4 to 6, respectively, (b) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain and a L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 11 to 13, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 14 to 16, respectively, (c) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain and a L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 21 to 23, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 24 to 26, respectively, (d) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain variable region (VH) and a L chain variable region (VL), wherein said VH and VL comprises the amino acid sequences of SEQ ID NO: 8 and SEQ ID NO: 10, respectively, and (e) a monoclonal antibody or an antigen-binding fragment thereof, each comprising VH and VL, wherein said VH and VL comprises the amino acid sequences of SEQ ID NO: 18 and SEQ ID NO: 20, respectively.