Patent ID: 6479488
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A compound of formula (I) a salt, or a metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO2R2 or COR2 wherein R2 represents hydroxy, methoxy, amino, alkylamino or dialkylamino: m is zero or an integer 1 or 2;R1 represents a group (CH2)nCN, â€”CH&boxH;CHR3, (CH2)nNHCOCH2R4 or O(CH2)pNR5R6; R3 represents cyano or the group COR7; R4 represents alkoxy or a group NHCOR8; R5 and R6 each represent independently hydrogen or alkyl, or R5 and R6 together with the nitrogen atom to which they are attached represent a heterocyclic group, or R5 is hydrogen and R6 is the group COR9; R7 represents an alkoxy, amino or hydroxyl group; R8 represents a hydrogen atom or optionally substituted alkyl, alkoxy, phenyl, heteroaryl or heterocyclic group; R9 is the group R8 or the group NR10R11 wherein R10 represents hydrogen or alkyl group; R11 represents optionally substituted alkyl, phenyl, heteroaryl , heterocyclic or cycloalkyl group; n is zero or an integer from 1 to 4; p is an integer from 2 to 4.