Patent ID: 9108921
Filing Date: 2015-08-18
Classification: A61P,C07D,C07F

Abstract:
1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: A is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted, and the aryl or heteroaryl is optionally fused to an optionally substituted carbocyclyl or an optionally substituted heterocyclyl; X is selected from —NH—S(O) Y is C(H) or N; provided that no more than two Y groups are N; R R each R each R each R n is 0, 1, 2 or 3; and m is 0, 1 or 2; provided that a compound of Formula (I) is not the following: (1) 4-[[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (2) 4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (3) 4-[[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (4) 4-[[4-(2-fluoro-5-methylphenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (5) 4-phenyl-1-[4-[(phenylamino)sulfonyl]benzoyl]-4-piperidinecarboxylic acid methyl ester; (6) 1-[4-[[(2-methylphenyl)amino]sulfonyl]benzoyl]-4-phenyl-4-piperidinecarboxylic acid methyl ester; (7) 1-[4-[methyl[(4-methylphenyl)sulfonyl]amino]benzoyl]-4-phenyl-4-piperidinecarboxylic acid; (8) 1-[4-[(methylphenylamino)sulfonyl]benzoyl]-4-phenyl-4-piperidinecarboxylic acid; (9) 1-[4-[(cyclopropylamino)sulfonyl]benzoyl]-4-phenyl-4-piperidinecarboxylic acid; or (10) 4-phenyl-1-[4-[[(2-thienylmethyl)amino]sulfonyl]benzoyl]-4-piperidinecarboxylic acid methyl ester.