Patent ID: 8524244
Filing Date: 2013-09-03
Classification: A61K,A61P,C07K

Abstract:
1. A polypeptide comprising a tenth fibronectin type III ( 10 Fn3 ) domain, wherein the 10 Fn3 domain (i) comprises a loop, AB; a loop, BC; a loop, CD; a loop, DE; a loop EF; and a loop FG; (ii) has at least one loop selected from loop BC, DE, and FG with an altered amino acid sequence relative to the sequence of the corresponding loop of the human 10 Fn3 domain, (iii) binds human epidermal growth factor receptor (EGFR) with a disassociation constant of less than 10 −4 M, and (iv) comprises an amino acid sequence at least 80% identical to any one of SEQ ID NOs: 207-231.