Patent ID: 6221856
Filing Date: 2001-04-24
Classification: A61K,A61P,C07F

Abstract:
A method for inhibiting superoxide anion production, comprising administering to a mammal in need of such inhibition a therapeutically effective amount of a compound havin the formula (I): ##STR5##or a racemate thereof, or a pharmaceutically acceptable salt thereof,wherein each RW is independently selected from the group consisting of hydrogen, --OH, --C.sub.1 -C.sub.20 straight or branched chain alkyl,--C.sub.2 -C.sub.20 straight or branched chain alkenyl or alkynyl, --OC(O)C.sub.1 -C.sub.20 straight or branched chain alkyl, --OC(O)C.sub.2 -C.sub.20 straight or branched chain alkenyl or alkynyl, --OC.sub.1 -C.sub.20 straight or branched chain alkyl, and --OC.sub.2 -C.sub.20 straight or branched chain alkenyl or alkynyl;each R.sup.2 is independently selected from the group consisting of hydrogen and --C(R.sup.3)(R.sup.3)OC(O)C.sub.1 -C.sub.4 straight or branched chain alkyl; andeach R.sup.3 is independently selected from the group consisting of hydrogen, --C.sub.1 -C.sub.12 alkyl, phenyl, and benzyl, or both R.sup.3 taken together form a 5- or 6-membered ring, said R.sup.3, except hydrogen, being unsubstituted or substituted with one or more halogen, --OH, C.sub.1 -C.sub.6 alkyl, NO.sub.2, --OC.sub.1 -C.sub.6 alkyl, and --OC(O)C.sub.1 -C.sub.6 alkl groups.