Patent ID: 8207309
Filing Date: 2012-06-26
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody polypeptide that specifically binds an exposed epitope shared by p53 mutant proteins and not by wild type p53 protein, wherein said polypeptide has affinity for said epitope of less than 25 nanomolar, and wherein said polypeptide comprises the amino acid sequences set forth in SEQ ID NO:5 (CDR1), SEQ ID NO:6 (CDR2) and SEQ ID NO:7 (CDR3) in a heavy chain of said antibody and the amino acid sequences set forth in SEQ ID NO:45 (CDR1), SEQ ID NO:46 (CDR2) and SEQ ID NO:47 (CDR3) in a light chain of said antibody; or the amino acid sequences set forth in SEQ ID NO:5 (CDR1), SEQ ID NO:6 (CDR2) and SEQ ID NO:7 (CDR3) in a heavy chain of said antibody and the amino acid sequences set forth in SEQ ID NO:60 (CDR1), SEQ ID NO:61 (CDR2) and SEQ ID NO:62 (CDR3) in a light chain of said antibody.