Patent ID: 8343493
Filing Date: 2013-01-01
Classification: A61K,A61P,C07K

Abstract:
1. A monoclonal antibody, Antibody Tei A 1.6, comprising: a light chain variable region: SSLTVTAGEKVTMSCKSSQSLLAGRYQKNYLTWYQQKPGQPPKLLIYWASTRDSGVPDRFTGSGS GTDFTLTISSVQAEDLAVYYCQNDYTYPLTFAG (SEQ ID NO :1), wherein complementarity determining regions of the light chain variable region (CDR-L) comprise the following sequences: CDR-L1: KSSQSLLAGRYQKNYLT (SEQ ID NO : 11) CDR-L2: WASTRDSG (SEQ ID NO : 12) CDR-L3: QNDYTYPLT (SEQ ID NO : 13); and a heavy chain variable region: GGLVQPGGSLRLSCAISGFTFSDFYMEWVRQPPGKRLEWIAASRNKANDYTTEYSASVKGRFIVS RDTSQSILYLQMNALRAEDTAIYYCATYHDYAMDYWGQGTSVTVSS (SEQ ID NO:2), wherein complementarity determining regions of the heavy chain variable region (CDR-H) comprise the following sequences: CDR-H1: GFTFSDFYME (SEQ ID NO : 14) CDR-H2: ASRNKANDYTTEYSASVKG (SEQ ID NO : 15), and CDR-H3: YHDYAMDY (SEQ ID NO : 16), wherein said monoclonal antibody specifically binds to the N-terminal region of Aβ 8-x peptide, x being comprised from 15 to 42, and recognises neither Aβ 1-40 nor Aβ 1-42 .