Patent ID: 6646120
Filing Date: 2003-11-11
Classification: A61P,C08B

Abstract:
Dextran derivatives of general formula DMCaBbSucSd, in which:D represents a polysaccharide chain, comprising concatenations of glucoside units, MC represented methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulfate groups, S represents sulfonate groups, a, b, c and d represent the degree of substitution (ds), expressed relative to the number of free hydroxyl functions in a dextran glucoside unit, with groups MC, B, Su and S, respectively; a being equal to 0 or &gE;0.3, b being equal to 0 or &gE;0.1, c being equal to 0 or &lE;0.1 and d being equal to 0 or &lE;0.15, with the proviso that when d=0, a and/or b are â‰ 0, which products display: homogeneity of the size distribution of the chains, illustrated by an elution profile of symmetrical Gaussian type in high performance steric exclusion chromatography, and homogeneity of the distribution of charged chemical groups, illustrated by an elution profile as a single symmetrical peak in low pressure ion exchange chromatography.