Patent ID: 7250405
Filing Date: 2007-07-31
Classification: A61K,A61P,C07K

Abstract:
1. A method of elevating prolactin levels in an offspring from a non-human female mammal comprising: electroporating an effective amount of a nucleic acid expression construct into muscle cells of the non-human female mammal prior to or during gestation of the offspring, wherein the nucleic acid expression construct contains a nucleic acid sequence encoding a growth hormone releasing hormone (“GHRH”) in the non-human female mammal during gestation; and wherein the vector comprises a promoter; a nucleotide sequence encoding the GHRH; and a 3′ untranslated region, under conditions that promote expression of the nucleotide sequence, and wherein the introduction and expression of the nucleic acid expression construct results in elevating prolactin levels in said offspring.