Patent ID: 6593335
Filing Date: 2003-07-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I: or a pharmacuetically acceptable salt, ester, amide, or prodrug thereof wherein, n is 1-2;R2 is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl; A is â€”R3; X is selected from the group consisting of C(O) and S(O)p; p is 1-2; R3 and R4 together form a ring selected from the group consisting of a 5-, 6-, or 7-membered carbocyclic ring with 1-2 double bonds and 0-4 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkynyl, arylalkoxy, amino, aminoalkoxy, aminoalkyl, haloalkenyl, haloalkyl, halogen, hydroxy, hydroxyalkenyl, hydroxyalkyl, and oxo, and a 5-, 6- or 7-membered sulfur-containing ring with 1-2 double bonds and 0-4 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkynyl, arylalkoxy, amino, aminoalkoxy, aminoalkyl, haloalkenyl, haloalkyl, halogen, hydroxy, hydroxyalkenyl, hydroxyalkyl, and oxo; and R1 and R5 together with the ring to which they are attached form a 5-, 6-or 7-membered sulfur-containing ring with 1-2 double bonds and 0-4 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkynyl, arylalkoxy, amino, aminoalkoxy, aminoalkyl, haloalkenyl, haloalkyl, halogen, hydroxy, hydroxyalkenyl, hydroxyalkyl, and oxo.