Patent ID: 6616938
Filing Date: 2003-09-09
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A method of making a chewing gum for treatment of H. pylori in the oral cavity and gastric mucosa, the method comprising:a) providing a chewing gum base, b) providing a non-H2 antagonist bismuth compound, which is therapeutically effective against H. pylori in the oral cavity, c) mixing the chewing base and the non-H2 antagonist bismuth compound in sufficient proportions such that the amount of the non-H2 antagonist bismuth compound in a suitable serving size of chewing gum is therapeutically effective, and d) shaping the mixture into a desired product form; wherein the non-H2 antagonist bismuth compound is selected from the group consisting of colloidal bismuth subcitrate, bismuth citrate, bismuth subcitrate, bismuth salicylate, bismuth subsalicylate, bismuth subnitrate, bismuth subcarbonate, bismuth tartrate, bismuth subgallate, bismuth aluminate, bismuth ascorbyl sulfate, bismuth sucrose sulfate, and combinations thereof.