Patent ID: 7534771
Filing Date: 2009-05-19
Classification: A61P,C07D,C07H

Abstract:
1. A compound of Formula I: wherein only one of the bonds between Z when the bond between Z when the bond between Z p is 0 or 1; each R is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl; when the bond between Z when the bond between Z each of Z Z Q is selected from the group consisting of alkyl and substituted alkyl; Q Q Q Y is selected from the group consisting of a bond, —CH wherein X is halo and each of W and W 1 is independently hydrogen or a pharmaceutically acceptable prodrug group selected from the group consisting of acyl, oxyacyl, phosphonate, phosphate esters, phosphate, phosphonamidate, phosphorodiamidate, phosphoramidate monoester, cyclic phosphoramidate, cyclic phosphorodiamidate, phosphoramidate diester, and —C(O)CHR 3 NHR 13 , where R 13 is hydrogen and R 3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic and a sidechain of an amino acid; or R 3 and R 13 together with the carbon and nitrogen atoms bound thereto respectively form a heterocyclic ring; or pharmaceutically acceptable tautomers, salts or partial salts thereof; provided that W 1 is a pharmaceutically acceptable prodrug group; and further provided that said compound, tautomer, salt, or partial salt is not represented by formula II or Ill or a tautomer, salt, or partial salt thereof wherein: Q′ is absent or is selected from the group consisting of O, S, and NH, provided that when Q′ is absent, V and NH are both attached to a CH V is selected from the group consisting of N and C-G; Z is selected from the group consisting of N and C-G′; V and Z are not identical; G and G′ are independently selected from the group consisting of hydrogen, amino, aminocarbonyl, methylamino, dimethylamino, acylamino, alkoxyamino, —SO A and B are independently selected from the group consisting of C=Q″, NH, and methylene optionally substituted with 1 to 2 halo groups, provided that A and B are not both NH; D is NH, or -D-A-B- together form a —N═CH—NH—, —(C=Q″)—CH each Q″ is independently selected from the group consisting of O, S, and NH; T T W, W