Patent ID: 6417399
Filing Date: 2002-07-09
Classification: A61P,C07B,C07C

Abstract:
A method for the stereoselective synthesis of the valnoctamide stereoisomers (2S,3S) and (2R,3S) comprising;(a) synthesizing (3S)-methyl valeric acid (I) from L-isoleucine; (b) subsequently synthesizing (3S)-methyl valeroyl chloride (II) from said (3S)-methyl valeric acid (I); (c) subsequently synthesizing (2S),(3S) valnoctic acid (IIIâ€²), or subsequently synthesizing (2R),(3S) valnoctic acid (III), from said (3S) methyl valeroyl chloride; and (d) subsequently synthesizing (2S),(3S) valnoctamide (Vâ€²), or (2R),(3S) valnoctamide (V), from said (2S),(3S) valnoctic acid (IIIâ€²), or said (2R),(3S) valnoctic acid (III), respectively.