Patent ID: 6726843
Filing Date: 2004-04-27
Classification: B01J,C40B,G01N

Abstract:
A method for evaluating the interaction between a receptor comprising natural or artificial mammalian tissue and a modifying agent in the presence of a liquid carrier, the method comprising:providing the receptor comprising natural or artificial mammalian tissue, and providing the modifying agent, one of the receptor and modifying agent being provided as a member of a combinatorial library having at least four members, conducting at least four test procedures with the receptor, modifying agent and liquid carrier being the same in each of the test procedures except that in each test procedure a different member of the combinatorial library is used, each of the test procedures comprising: (a) injecting a liquid test sample comprising the modifying agent into a stream of the liquid carrier, the injection being carried out over a limited time so that a distinct test section of the stream contains the test sample, (b) passing the stream of liquid carrier containing the test sample over a solid phase in a test chamber, the solid phase comprising the receptor, and (c) examining the stream of liquid carrier leaving the test chamber to ascertain a variable which reflects the interaction of the modifying agent and the receptor in the presence of the liquid carrier.