Patent ID: 6124502
Filing Date: 2000-09-26
Classification: C07C,C07D

Abstract:
A process for the preparation of a compound according to the formula ##STR9## where R.sup.1 is C.sub.1 -C.sub.12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, carboxyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxamido, nitrile, mono- or di-(C.sub.1 -C.sub.6)alkylamino, thio, C.sub.1 -C.sub.6 alkylthio, aryl, --Oaryl or --OCH.sub.2 aryl where aryl is optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, carboxy, halogen, cyano, nitro, carboxamido, or hydroxy; and C.sub.1 -C.sub.6 alkanesulfonyloxy and aryl is a 5 to 10 membered carbocyclic or heterocyclic mono or bicyclic aromatic group selected from the benzene, furan, thiophene, imidazole, naphthalene, quinoline, indole, benzothiophene, benzimidazole, pyridine, pyrimidine, and benzofuran; and R.sup.2 and R.sup.6 together form carbonyl which comprises:(1) oxidation of compound of the formula ##STR10## or ##STR11## where R.sup.1, R.sup.2 and R.sup.6 are as previously defined, Y is hydrogen and Z is phenyl, --CR.sup.3 R.sup.4 R.sup.5 where R.sup.3, R.sup.4 and R.sup.5 are independently H, methyl, --O--C.sub.1 -C.sub.12 alkyl, O-tetrahydropyranyl, --S-benzyl, phenyl optionally substituted with methoxy, hydroxy, nitro, or methyl; disulfides or any other group suitable for protecting sulfur, and(2) removal of the thiol protecting group to give a compound where R.sup.2 and R.sup.6 together forms carbonyl.