Patent ID: 6218359
Filing Date: 2001-04-17
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
A method of treating autoimmune, arthritic and tumor diseases comprising administering a compound of formula (1), (2) or (3) ##STR19##whereinR.sub.1 and R.sub.5 are C.sub.3 -C.sub.5 alkyl, C.sub.3 -C.sub.5 alk-2-en-1-yl or C.sub.3 -C.sub.5 alk-2-yn-1-yl; and especially allyl, methallyl and propinyl;R.sub.2 and R.sub.6 are hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.5 alk-2-en-1-yl, C.sub.3 -C.sub.5 alk-2-yn-1-yl, aryl, aryl lower alkyl, saturated or unsaturated heterocyclyl lower alkyl or lower alkoxy carbonyl lower alkyl;R.sub.3 and R.sub.4 are each independently of the other hydrogen, lower alkyl or together form lower alkylidene;X is oxo or sulfo;R.sub.34 and R.sub.35 are independent of the other hydrogen, methoxy, or fluoro;R.sub.35 is hydrogen or methoxycarbonyl,R.sub.37 is oxo or sulfo;R.sub.38 is hydrogen, C.sub.1 -C.sub.6 alkyl, cyclopropyl, cycloputyl, cyclopentyl, cyclohexyl, C.sub.1 -C.sub.6 alkyl substituted by Br, Cl, F or I, phenyl, C.sub.1 -C.sub.3 alkyl-benzene, substituted or unsubstituted by halogen, indolyl, morpholino, methylmorpholino, amino, amino substituted with C.sub.1 -C.sub.4 alkyl or 1-(2',3',4'-trimethoxybenzyl)piperazine-methyl, 2-pyrrolidinone;R.sub.39 is hydrogen, methyl or fluoro;R.sub.40 is a carbon or nitrogen atom;R.sub.41 is a carbon or nitrogen atom or a carbonyl group;R.sub.42 is a carbon, nitrogen or sulfur atom or a vinylene group;the bond between R.sub.40 and R.sub.41 may be a single or double bond, with the proviso that it is a single bond if R.sub.41 is a carbonyl group or R.sub.40 is a nitrogen atom to a patient in need thereof.