Patent ID: 6573377
Filing Date: 2003-06-03
Classification: A61P,C07D

Abstract:
A compound represented by formula (I): whereinR1 represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxyl group, an amino group, an alkylamino group, an aryl group or an alkyl group, wherein the alkyl group may have a substituent selected from a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group and an alkylthio group; R2 represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxyl group, an amino group, an alkylamino group, an aryl group, or an alkyl group, wherein the alkyl group may have a substituent selected from a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group and an alkylthio group; R3 represents a hydrogen atom, a halogen atom, an alkoxyl group, an amino group, an alkylamino group, an aryl group or an alkyl group, wherein the alkyl group may have a substituent selected from a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group and an alkylthio group; R4 represents a hydrogen atom, a halogen atom, an alkoxyl group, an amino group, an alkylamino group, an aryl group or an alkyl group, wherein the alkyl group may have a substituent selected from a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group and an alkylthio group; R5 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or an arylalkyl group, wherein the alkyl group may have a substituent selected from a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group and an alkylthio group; Q represents an amidino group, a phenyl group or a monocyclic heterocyclic ring group, wherein said monocyclic heterocyclic ring group is a five- or six-membered ring, the heteroatoms of the heterocyclic ring are selected from the group consisting of O, N and S, and said heterocyclic ring may be saturated or unsaturated, and wherein the amidino group, phenyl group and monocyclic heterocyclic ring group may have one or more substituents selected from the group consisting of an alkyl group (which may be substituted by a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group or an alkylthio group), a halogen atom, a hydroxyl group, an alkoxyl group, an alkoxylalkoxyl group, an amino group, an alkylamino group, an acylamino group, an alkylaminoalkylamino group, a nitro group, a cyano group, a carbamoyl group, a mercapto group, an alkylthio group, an arylthio group, an alkylsulfinyl group, an arylsulfinyl group, an alkylsulfonyl group, an arylsulfonyl group, an aminosulfonyl group, an alkylaminosulfonyl group, an arylaminosulfonyl group and an aryl group; and G represents a condensed tricyclic heterocyclic ring, wherein said condensed tricyclic heterocyclic ring comprises at least one heterocyclic ring, each of the rings of the condensed tricyclic heterocyclic ring is independently a five- to seven-membered ring, the heteroatoms of the heterocyclic ring are selected from the group consisting of O, S, and N, and each of the rings of the condensed tricyclic heterocyclic ring is independently saturated or unsaturated, and wherein the condensed tricyclic heterocyclic ring may have one or more substituents selected from the group consisting of an alkyl group (which may be substituted by a halogen atom, an amino group, an alkylamino group, a hydroxyl group, an alkoxyl group, a mercapto group or an alkylthio group), a halogen atom, a hydroxyl group, an alkoxyl group, a mercapto group, an alkylthio group, an amino group, an alkylamino group, an acylamino group, a nitro group, a cyano group, a carbamoyl group and an aryl group, the condensed tricyclic heterocyclic ring may have an epoxy group and the condensed tricyclic heterocyclic ring may also have a carbonyl group as a constituent element of the ring or a salt thereof, with the proviso that, in said compound and a salt thereof, a compound in which G is a condensed tricyclic heterocyclic ring, and a saturated or unsaturated hydrocarbon ring or heterocyclic ring of the condensed ring can be represented by a saturated hydrocarbon ring or saturated heterocyclic ring having no substituent, (excluding a case in which Q is a pyrimidinyl group and binds at the 2-position), and a salt thereof are excluded.