Patent ID: 9157125
Filing Date: 2015-10-13
Classification: C12Q

Abstract:
1. A method of diagnosing a human subject as having melanoma, or susceptible to developing melanoma, comprising: detecting the presence of at least one mutation in the glutamate receptor, ionotropic, N-methyl-D-aspartate 2A (GRIN2A) gene (SEQ ID NO: 3) in a biological sample obtained from the human subject, wherein the at least one mutation comprises C2671 T and detecting the presence of the C2671 T mutation comprises amplification of nucleic acid from the biological sample using the primers of SEQ ID NO: 45 and SEQ ID NO: 46, and diagnosing the human subject as having melanoma or susceptible to developing melanoma based on the detection of the presence of the C2671T mutation.