Patent ID: 6809177
Filing Date: 2004-10-26
Classification: A61P,C07K,Y10S

Abstract:
A process for converting mulundocandin of formula I: wherein each of W, x, Y and Z is OH, R is H and Râ€² is 12-methyl-tetradecanoyl, to deoxymulundocandin, a compound of formula I wherein W, Y and Z are each OH, X and R are each H and Râ€² is 12-methyl-tetradecanoyl, this process comprising reducing the C4-htyr (homotyrosine) hydroxyl group of said mulundocandin by mixing said mulundocandin with Raney Nickel in a solvent selected from the group consisting of methanol, ethanol and dioxane at a pH of 3-7 without protecting and then deprotecting the C5-orn (ornithine) hydroxyl group, and then purifying the resulting deoxymulundocandin from the crude reaction mixture.