Patent ID: 7084176
Filing Date: 2006-08-01
Classification: A61K,A61P,C07C,C07D

Abstract:
1. An N-arylphenylacetamide derivative of the following formula (I): (wherein R 1 is a C 1-6 alkoxy group, a hydroxy group, a halogen atom, a nitro group, an amino group, a C 1-6 alkylamino group, a di-(C 1-6 alkyl)-amino group, a C 1-6 alkylsulfonylamino group, or an arylsulfonylamino group, R R R [in which Y is a single bond, a C 1-3 alkylene group, a C 2-3 alkenylene group, a C 2-3 alkynylene group, —CO(CH 2 ) p —, a C 2-3 alkenylenecarbonyl group, —O—, —O—(CH 2 ) 2 —, —O—(CH 2 ) 3 —, or —CONH(CH 2 ) p —, and p is an integer of 0 to 3, R 8 is a monocyclic group or a polycyclic group consisting of a 5- or 6-membered aromatic ring containing 0 to 3 heteroatoms selected from N, O and S, which may optionally be substituted by 1 to 3 atoms or groups selected from a halogen, a C 1-6 alkyl, a C 3-7 cycloalkyl, a C 2-6 alkenyl, a C 2-6 alkynyl, a trifluoromethyl, a trifluoroethyl, an aryl, an aryl-C 1-6 alkyl, a C 1-6 alkoxy, a trifluoromethoxy, a C 3-7 cycloalkyloxy, an aryloxy, an aryl-C 1-3 alkyloxy, a C 1-6 alkylcarbonyl, a C 3-7 cycloalkylcarbonyl, a formyl, a nitro, an amino, a di-(C 1-6 alkyl)amino, a cyano, a hydroxy, a C 1-3 alkylthio, a C 1-4 alkoxycarbonyl-C 1-3 alkyl, a carboxy-C 1-3 alkyl, a C 1-4 alkoxycarbonyl, an aryl-C 1-3 alkyloxycarbonyl, a carboxy and a sulfamoyl; a C 5-7 cycloalkenyl group which may optionally be substituted by 1 to 4 atoms or groups selected from a C 1-6 alkyl, a C 3-7 cycloalkyl, a halogen, a trifluoromethyl, a C 1-4 alkoxycarbonyl, an aryl, an aryl-C 1-6 alkyl, a C 1-3 alkoxy and a hydroxy; or a group of the formula (B): (R a , R b , R c and R d are the same or different and each is a hydrogen atom, a C 1-6 alkyl group, a C 3-7 cycloalkyl group, a halogen atom, a trifluoromethyl group, a C 1-4 alkoxycarbonyl group, an aryl group, an aryl-C 1-6 alkyl group, a C 1-3 alkoxy group or a hydroxy group, or when R a and R b attach to the same carbon atom, then these groups may combine to form an oxo group or a thioxo group, or when R c and R d attach to the same carbon atom, then these groups may combine together with said carbon atom to form a spiro ring, or 2 or 3 groups selected from R a , R b and R c may combine to form a C 6-15 polycycloalkyl group, and n is an integer of 1 to 6)], and the group of the formula (C) is a group of the formula: (R e and R f are the same or different and each is a hydrogen atom, a C 1-6 alkyl group, a C 3-7 cycloalkyl group, a halogen atom, a trifluoromethyl group, a C 1-4 alkoxycarbonyl group, an aryl group, an aryl-C 1-6 alkyl group, a C 1-3 alkoxy group or a hydroxy group, or when R e and R f attach to the same carbon atom, then these groups may combine together with said carbon atom to form a spiro ring, and Z is a carbon atom, an oxygen atom or a sulfur atom), R or R X or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.