Patent ID: 6534639
Filing Date: 2003-03-18
Classification: A61P,C07H

Abstract:
An oligomer comprising a plurality of nucleotide units of the formula: wherein:Bx is a heterocyclic base; each T1 and T2 is, independently, OH, a protected hydroxyl, a nucleotide, a nucleoside or an oligonucleotide; T3 is H, OH, a protected hydroxyl or a sugar substituent group; said oligomer further comprising at least one group, R1, therein; said R1 group occurring at the 3â€² end, the 5â€² end, in lieu of at least one T3 or as a substituent on at least one Bx; said R1 group having the formula: wherein:each Z is, independently, a single bond, O, N or S; each R2, R3, R3â€², and R4 is, independently, hydrogen, C(O)R5, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, alkylsulfonyl, arylsulfonyl, a chemical functional group or a conjugate group, wherein the substituent groups are selected from hydroxyl, amino, alkoxy, carboxy, benzyl, phenyl, nitro, thiol, thioalkoxy, halogen, alkyl, aryl, alkenyl and alkynyl; or R3 and R4, together, are R7; each R5 is, independently, substituted or unsubstituted C1-C10 alkyl, trifluoromethyl, cyanoethyloxy, methoxy, ethoxy, t-butoxy, allyloxy, 9-fluorenylmethoxy, 2-(trimethylsilyl)-ethoxy, 2,2,2-trichloroethoxy, benzyloxy, butyryl, iso-butyryl, phenyl or aryl; each R7 is, independently, hydrogen or forms a phthalimide moiety with the nitrogen atom to which it is attached; each m is, independently, zero or 1; and each n is, independently, an integer from 1 to about 6.