Patent ID: 6727357
Filing Date: 2004-04-27
Classification: A61K,A61Q,C11D

Abstract:
A process for making alkoxylated alkyl glucosides comprising lipophilic substituents wherein at least 5 wt. % of the alkyl glucosides have about three moles of said lipophilic substituents per mole of glucose, said process comprising:(i) contacting an alkyl glucoside with a lipophilic reagent selected from the group consisting of fatty acids, fatty esters, epoxides, halides, glycidyl ethers, vegetable oils and animal oils under reaction conditions effective to form a lipophilic glucose intermediate comprising lipophilic substituents wherein at least 75 wt. % of the alkyl glucoside has two moles of said lipophilic substituents per mole of glucose; and (ii) contacting the lipophilic glucose intermediate with an alkylene oxide at reaction conditions effective to form an alkoxylated, lipophilic glucose intermediate substituted with the alkylene oxide; and (iii) contacting the alkoxylated, lipophilic glucose intermediate with a lipophilic reagent under reaction conditions effective to form the alkoxylated alkyl glucoside comprising lipophilic substituents wherein at least 5 wt. % of the alkyl glucosides have about three moles of said lipophilic substituents per mole of glucose.