Patent ID: 8039455
Filing Date: 2011-10-18
Classification: A61P,C07D

Abstract:
1. A compound of the formula in which R R R Ar is a phenylene ring, which ring is optionally substituted with halogen, (C U is a bond, O, CF  either V V  or V W is CH═CH, cycloprop-1,2-ylene, phen-1,2-ylene, CH X is an optionally substituted phenylene or pyridinyl ring, whereby Y and C(═O)NR X Y is O or NH; and Z is O, CH the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form; wherein the optional substituents on alkyl, alkoxy or cycloalkyl groups or moieties are one to three groups, independently selected from hydroxy, hydroxy(C the optional substituents on chroman-4-yl, isochroman-4-yl, thiochroman-4-yl, isothiochroman-4-yl, 1,1-dioxo-1lambda*6*-thiochroman-4-yl, 2,2-dioxo-2lambda*6*-isothiochroman-4-yl, 1,2,3,4-tetrahydro-quinol-4-yl, 1,2,3,4-tetrahydro-isoquinol-4-yl, 1,2,3,4-tetrahydro-naphth-1-yl, 1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6* -benzo[e][1,2]thiazin-4-yl, 2,2-dioxo-1,2,3,4-tetrahydro-2lambda*6*-benzo[c][1,2]thiazin-4-yl, 1,1-dioxo-3,4-dihydro-1H-1lambda*6*-benzo[c][1,2]oxathiin-4-yl, 2,2-dioxo-3,4-dihydro-2H-2lambda*6*-benzo[e][1,2]oxathiin-4-yl, 2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl, 1,3,4,5-tetrahydro-benzo[c]oxepin-5-yl, non-aromatic heterocyclyl, aryl or heteroaryl rings or moieties are one to three groups independently selected from hydroxy, optionally substituted (C an optionally substituted aryl or heteroaryl group may also carry, as optional substituents, one to three groups selected from benzyloxy, phenoxy, S(═O) optional substituents on amino groups can be one or two groups independently selected from (C optional substituents on carbamoyl can be one or two groups selected from (C aryl is naphthyl or phenyl; a heteroaryl is an aromatic 5- or 6-membered ring, in which 1, 2 or 3 ring atoms are hetero atoms independently selected from O, N and S; and a non-aromatic heterocyclyl is a non-aromatic 5- or 6-membered ring, in which 1, 2 or 3 ring atoms are hetero atoms independently selected from O, N and S.