Patent ID: 8343140
Filing Date: 2013-01-01
Classification: A61K,A61P

Abstract:
1. A dual osmotic delivery device, comprising: an impermeable reservoir having outer and inner surfaces and first and second ends, wherein the reservoir defines a first chamber adjacent the first end of the reservoir in fluid communication with second and third essentially columnar chambers that extend to the second end of the reservoir, each of the second and third chambers defining an open end, wherein each of (i) the first chamber and second chamber, and (ii) the first chamber and the third chamber defines a flow path through the reservoir; a first piston and a second piston located in the second and third chambers, respectively, wherein the pistons isolate the first chamber from the second and third chambers; an osmotic agent formulation in the first chamber; a semi-permeable membrane in sealing relationship with the open end of the first chamber; and a first beneficial agent formulation in the second chamber, wherein (i) the first beneficial agent formulation comprises a first polypeptide formulated into a first particle formulation, and (ii) the first particle formulation is suspended in a first viscous vehicle; a second beneficial agent formulation in the third chamber, wherein (i) the second beneficial agent formulation comprises a second polypeptide formulated into a second particle formulation, and (ii) the second particle formulation is suspended in a second viscous vehicle; and a diffusion moderator in mating relationship with the end of the reservoir, wherein the diffusion moderator defines a first orifice through which the first beneficial agent formulation is capable of exiting the second chamber, and a second orifice through which the second beneficial agent formulation is capable of exiting the third chamber, and the diffusion moderator effectively isolates the first and second beneficial agent formulations, within, respectively, the second and third chambers, from the environment of use.