Patent ID: 8372618
Filing Date: 2013-02-12
Classification: A61P,C12N

Abstract:
1. A purified mutated hyperthermophilic phosphotriesterase (PTE) having a lactonase activity derived from a hyperthermophilic PTE corresponding to the consensus sequence of SEQ ID NO: 1, said mutated PTE comprising at least one mutation selected from the group consisting of: substitution of the tyrosine Y in position 98, substitution of the tyrosine Y in position 100, substitution of the arginine R in position 224, and substitution of the cysteine C in position 259, of SEQ ID NO: 1 by any other natural or non-natural amino acid, said mutated hyperthermophilic PTE having a lactonase activity that is greater than that of a non-mutated hyperthermophilic PTE from which it is derived.