Patent ID: 7504479
Filing Date: 2009-03-17
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An immunogenic polypeptide for inducing antibodies that neutralize the immunosuppressive and/or angiogenic activity of an E7 protein from Papillomavirus, wherein said immunogenic polypeptide consists of an E7 protein from Papillomavirus, or a protein derived therefrom having the sequence of the E7 protein from Papillomavirus except with 10% or less of the amino acid residues being deleted, that has been inactivated, so as to eliminate at least 70% of the immunosuppressive and/or angiogenic activity of the non-inactivated E7 protein, by a chemical treatment selected from the group consisting of treatment carried out with the aid of a coupling agent, treatment carried out with the aid of a carrier protein activated by pre-treatment with a dialdehyde, treatment with a monoaldehyde, carboxymethylation, carboxyamidation, and maleimidation.