Patent ID: 6932777
Filing Date: 2005-08-23
Classification: A61K,C12N

Abstract:
1. A method of treating the ductal epithelium of a mammary gland therapeutically for cancer, which method consists of contacting, by ductal cannulation, the ductal epithelium of the mammary gland with a composition consisting of one or more cytotoxic compounds selected from the group consisting of genistein, okadaic acid, 1-β-D-arabinofuranosyl-cytosine, arabinofuranosyl-5-aza-cytosine, cisplatin, carboplatin, actinomycin D, asparaginase, bis-chloro-ethyl-nitroso-urea, bleomycin, chlorambucil, cyclohexyl-chloro-ethyl-nitroso-urea, cytosine arabinoside, duanomycin, etoposide, hydroxyurea, melphalan, mercaptopurine, mitomycin C, nitrogen mustard, procarbazine, teniposide, thioguanine, thiotepa, vincristine, 5-flurouracil, 5-fluorocytosine, cyclophosphamide, methotrexate, vinblastine, doxorubicin, leucovorin, taxol, an anti-estrogen agent, an intracellular antibody against an oncogene, a flavonol, Guan-mu-tong extract, a retinoid, an analogue of a retinoid, and a monoterpene to destroy the ductal epithelium so as to inhibit the spread of cancer.