Patent ID: 7279159
Filing Date: 2007-10-09
Classification: A61K,A61P,C07K

Abstract:
1. A fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) consisting of components (R1R2) X , and a multimerizing component (MC) capable of interacting with another MC to form a multimeric structure, wherein X≧1, R1 is VEGF receptor component Ig domain 2 of Flt-1 consisting of amino acids 27-126 of SEQ ID NO:8 or 27-129 of SEQ ID NO:10, R2 is Ig domain 3 of Flk-1 consisting of amino acids 127-228 of SEQ ID NO:8 or 130-231 of SEQ ID NO:10, and MC comprises CPPC (SEQ ID NO:1).