Patent ID: 6037447
Filing Date: 2000-03-14
Classification: A61K,C07K

Abstract:
A compound of the formula: ##STR90## wherein each of G and G' is independently deshydrovancomycin of the formula: ##STR91## or deshydroA82846B of the formula: ##STR92## wherein Y.sup.1 is OH or ##STR93## and Y.sup.2 is defined as follows: (1) each Y.sup.2 independently representshydrogen,alkyl of C.sub.1 -C.sub.10,cycloalkyl of C.sub.5 -C.sub.6,cycloalkenyl of C.sub.5 -C.sub.6,naphthyl,biphenylyl,a radical of the formula --Y.sup.3 --(Y.sup.4).sub.0, 1, or 2, wherein Y.sup.3 is loweralkyl of C.sub.1 -C.sub.6 optionally substituted by from one to three substituents, each of which is independently selected from the group consisting of halo, nitro, cyano, alkoxy, haloalkyl, and haloalkoxy; and Y.sup.4 is ##STR94## wherein each Y.sup.5 is independently hydrogen or loweralkyl of C.sub.1 -C.sub.4, or Y.sup.4 is phenyl or phenyl substituted with from one to three substituents, each of which is independentlyhalo,nitro,loweralkyl of C.sub.1 -C.sub.4,cycloalkyl of C.sub.5 -C.sub.6,loweralkoxy of C.sub.1 -C.sub.4,haloloweralkyl of C.sub.1 -C.sub.4, orhaloloweralkoxy of C.sub.1 -C.sub.4 ; or(2) one Y.sup.2 is hydrogen and the other Y.sup.2 is (2-furanon-3-yl); or(3) both Y.sup.2 moieties are taken together with the nitrogen and constitute a five- to seven-membered heterocyclic ring optionally containing in addition to the indicated nitrogen atom one additional hetero ring atom which is nitrogen, oxygen, or sulfur, and which heterocyclic radical can be unsubstituted or substituted with from one or two substituents, each of which is loweralkyl of C.sub.1 -C.sub.2, loweralkoxy of C.sub.1 -C.sub.2, phenyl, benzyl, or C.sub.1 -C.sub.6 -alkanoyl; and L is a divalent linking radical of the formula Ia: ##STR95## wherein A is: alkylene of C.sub.1 -C.sub.16,(Z.sup.1 --X').sub.q --Z.sup.1, ##STR96## where q is 1-3, each Z.sup.1 is independently an alkylene of C.sub.1 -C.sub.4, each Z.sup.2 is independently an alkylene of C.sub.1 -C.sub.8, each Z.sup.3 is independently an alkylene of C.sub.1 -C.sub.2, each X is independently --O-- or ##STR97## where R.sup.2 is H or loweralkyl of C.sub.1 -C.sub.4 ; and each X' is independently --O--, --S--, or ##STR98## where R.sup.2 is as defined above, and each R independently represents halo, loweralkyl of C.sub.1 -C.sub.6, loweralkoxy of C.sub.1 -C.sub.6, phenyl, or phenyl substituted by from 1 to 2 substituents, each of which is independently halo, loweralkyl of C.sub.1 -C.sub.6, or loweralkoxy of C.sub.1 -C.sub.6,each R.sup.1 is independentlyCH.sub.2,O,S, ##STR99## wherein R, X, X' and R.sup.2 are as defined above; or L is a divalent linking radical of the formula Ib:--Z.sup.4 --R.sup.3 --X""--R.sup.3 --Z.sup.4 -- Ibwherein each Z.sup.4 is independently an alkylene of C.sub.1 -C.sub.8 ; X"" represents alkylene of C.sub.1 -C.sub.4 or a phenylene of the formula ##STR100## wherein R is as defined above; and each R.sup.3 is independently CH.sub.2 or O; or a salt thereof.