Patent ID: 6624202
Filing Date: 2003-09-23
Classification: A61K,A61P

Abstract:
A method of inhibiting a human semicarbazide-sensitive amine oxidase (SSAO), comprising contacting said amine oxidase with an inhibitory amount of a hydrazino compound of Formula I or Formula II: or a stereoisomer or pharmaceutically acceptable solvate, hydrate, or salt thereof; wherein:R1 is hydrogen, (C1-C4)alkyl, aralkyl, (C2-C5)alkanoyl, aroyl or heteroaroyl; R2 is hydrogen, or optionally substituted (C1-C4)alkyl, optionally substituted cycloalkyl or optionally substituted aralkyl; R3-R6, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, optionally substituted aralkyl, optionally substituted phenyl or optionally substituted heteroaryl; or R1 and R2, together with the atoms to which they are attached, represent an optionally substituted heterocycle, or R2 and R3, together with the atoms to which they are attached, represent an optionally substituted heterocycle, or R3 and R5, together with the atoms to which they are attached, represent a saturated, optionally substituted carbocycle; R7 is hydrogen, (C1-C4)alkyl, (C2-C5)alkanoyl or aralkyl; R8 is (C1-C4)alkyl or aralkyl; n is 1, 2 or 3; and X is chloride, bromide, iodide or R2-sulfate, where R2 is as defined herein.