Patent ID: 7557125
Filing Date: 2009-07-07
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method for screening for an inhibitor of Fab I or Fab K which comprises: (i) providing a reaction mixture comprising Fab I or Fab K, crotonyl-ACP and NAPDH or NADH; (ii) contacting a candidate compound to said reaction mixture; and (iii) detecting inhibition of Fab I or Fab K wherein said candidate compound is represented by formula (I): wherein: R R R  indicates that one of the two designated bonds is a double bond and the other is a single bond; R R R Y is H, C each X independently is H, C W is S or O; Q is H or C M is CH L is CH E is O or NR′; each R′ independently is H, C r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.