Patent ID: 6303622
Filing Date: 2001-10-16
Classification: A61P,C07D,Y02P

Abstract:
Benzo[c]quinolizine compounds of formula (I) ##STR6##wherein:R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6 are the same or different, and are chosen from the group consisting of: H, C.sub.1-8 alkyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, phenyl, naphthyl, halogen, NRR', C.sub.1-8 alkylamino, arylamino, C.sub.1-8 alkyloxy, aryloxy, COOR, wherein R and R' are the same or different and are selected from the group consisting of: H, C.sub.1-8 alkyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, phenyl, naphthyl, arylC.sub.1-8 alkyl; R.sub.5 is selected from the group consisting of: H, C.sub.1-8 alkyl, COOR, where R is as above defined or is phenyl or naphthyl;X is O;Q is a single bond;W is selected from the group consisting of: C.sub.1-8 alkyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, trifluoromethyl, C.sub.1-8 alkoxy, C.sub.1-8 alkoxy-C.sub.1-8 alkyl, arylC.sub.1-8 alkyl, phenyl, naphthyl, aryloxy, arylamino, C.sub.1-8 alkylcarbonyl, arylcarbonyl, halogen, NRR', C.sub.1-8 alkylamino, wherein the alkyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, phenyl or naphthyl groups may be substituted by OR, phenyl, NRR', COOR, halogen, C.sub.1-8 alkyl, where R and R' are as above defined;n is an integer between 1 and 4; the symbol ----- means that the corresponding bonds a, b, c, d, e, f and g can be single or double bonds; with the proviso that when b or f are a double bond then the group R.sub.5 is absent; and with the proviso that the following two compounds are excluded from the claim: 4-carbonitril-2,3-dihydro-(1H)-benzo[c]quinolizine-3-one and 3,4-dihydro-1'-phenyl-4aH-benzo[c]quinolozin-3-one; or a pharmaceutically acceptable salt or ester of formula (I).