Patent ID: 8178086
Filing Date: 2012-05-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of activating T cells of a vertebrate subject, wherein said T cells recognize an epitope of a hepatitis C virus (HCV) polypeptide, said method comprising: administering at least once a first composition comprising an HCV E1E2 protein complex to said vertebrate subject; and subsequently administering at least once a second composition comprising a viral vector comprising a nucleic acid sequence encoding a HCV E1 and HCVE2 polypeptide to said vertebrate subject, whereby an HCV E1E2 complex is expressed in one or more cells of the subject, wherein the viral vector is a chimeric defective alphavirus particle; whereby T cells are activated in said subject and said activated T cells recognize an epitope of E1 and/or E2 polypeptide.