Patent ID: 6075044
Filing Date: 2000-06-13
Classification: A61K,C07D

Abstract:
A method of treating a disease state in mammals that is alleviated by treatment with an inhibitor of hypoxanthine-guanine-xanthine phoshoribosyltransferase or guanine phosphoribosyltransferase in the purine salvage pathways of parasitic protozoa, which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I: ##STR5## wherein: R.sup.1 and R.sup.2 are independently chosen from the group consisting of hydrogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, halo, nitro, --NR.sup.3 R.sup.4, --N(CO)R.sup.3, and --C(O)NR.sup.3 R.sup.4 ;W is --C(R.sup.3)(R.sup.4)--, --NH--, --O--, or --S(O).sub.n --;X is C.dbd.O, C.dbd.S, or CH(OH);Y is .dbd.N--NR.sup.3 --, .dbd.N--N.dbd.C(R.sup.3)--, .dbd.N--N.dbd., --N(R.sup.3)--N(R.sup.4)--, .dbd.C(R.sup.3)--, or .dbd.C--NR.sup.3 --; andZ is --(C(O)).sub.m --(CR.sup.3 R.sup.4).sub.n --(O).sub.p --;in which:R.sup.3 and R.sup.4 at every occurrence are independently hydrogen or lower alkyl;m is 0 or 1;n is 0, 1, 2, 3, or 4;p is 0 or 1; andAr is aryl or heteroaryl;or a pharmaceutically acceptable salt, ester or N-oxide thereof.