Patent ID: 6888022
Filing Date: 2005-05-03
Classification: A61K,C07K

Abstract:
1. A method for inhibiting β-amyloid peptide release and/or its synthesis in a cell which method comprises administering to such a cell an amount of a compound or a mixture of compounds effective in inhibiting the cellular release and/or synthesis of β-amyloid peptide wherein said compounds are represented by the formula I: wherein R R each R each R each R X is selected from the group consisting of —C(O)Y and —C(S)Y where Y is selected from the group consisting of X can also be —CR X′ is hydrogen, hydroxy, or fluoro; X″ is hydrogen, hydroxy or fluoro, or X′ and X″ together form an oxo group, Z is selected from the group consisting of a bond covalently linking R n is an integer equal to 1 or 2; and pharmaceutically acceptable salts thereof with the provisos that: A. when R B. when R C. when R′ is phenyl, R D. when R E. when R F. when R G. when R H. when R I. when R J. when R K. when R L. when R M. when R N. when R O. when R P. when n is 2, R R. when n is 2, R S. when n is 1, R T. when n is 2, R U. when n is 2, R V. when n is 1, R W. when Z is a bond, or —O—, R X. when Z is a bond or —O—, X′ and X″ are hydrogen and X is —C(O)Y, then Y is not haloalkyl, heterocyclic, heterocyclicmethylene-, alkoxymethylene-, phenoxymethylene-, benzyloxymethylene-, phenoxymethylene-, thioalkoxymethylene-, thiophenoxymethylene-, thiobenzyloxymethylene-, plienthioethoxylmethylene-, —NR′R″ wherein R′ and R″ are independently hydrogen, alkyl, phenyl, benzyl or phenethyl, or substituted alkyl having a terminal diazo, amino, substituted amino or —C(O) alkyl OR Y. when Z is a bond or —O—, X′ and X″ are each hydrogen, X is —CR