Patent ID: 6331541
Filing Date: 2001-12-18
Classification: C07D

Abstract:
A compound of formula (I): ##STR329##or stereoisomers or pharmaceutically acceptable salts thereof, wherein:M is selected from CH.sub.2, CHR.sup.5, CHR.sup.13, CR.sup.13 R.sup.13, and CR.sup.5 R.sup.13 ;Q is selected from CHR.sup.13, CR.sup.13 R.sup.13, and CR.sup.5 R.sup.13 ;J, K, and L are independently selected from CH.sub.2, CHR.sup.5, CHR.sup.6, CR.sup.6 R.sup.6 and CR.sup.5 R.sup.6 ;with the proviso at least one of M, J, K, L, or Q contains an R.sup.5 ;Z is selected from O, S, NR.sup.1a, CHCN, CHNO.sub.2, and C(CN).sub.2 ;R.sup.1a is selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, CONR.sup.1b R.sup.1b, OR.sup.1b, NO.sub.2, CN, and (CH.sub.2).sub.w phenyl;R.sup.1b is independently selected from H, C.sub.1-3 alkyl, C.sub.3-6 cycloalkyl, and phenyl;E is --(CR.sup.7 R.sup.8)--(CR.sup.9 R.sup.10).sub.v --(CR.sup.11 R.sup.12)--; R.sup.1 and R.sup.2 are independently selected from H, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.a ;R.sup.a, at each occurrence, is selected from C.sub.1-4 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, (CF.sub.2).sub.r CF.sub.3, NO.sub.2, CN, (CH.sub.2).sub.r NR.sup.b R.sup.b, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OR.sup.c, (CH.sub.2).sub.r SH, (CH.sub.2).sub.r SR.sup.c, (CH.sub.2).sub.r C(O)R.sup.b, (CH.sub.2).sub.r C(O)NR.sup.b R.sup.b, (CH.sub.2).sub.r NR.sup.b C(O)R.sup.b, (CH.sub.2).sub.r C(O)OR.sup.b, (CH.sub.2).sub.r OC(O)R.sup.c, (CH.sub.2).sub.r CH(.dbd.NR.sup.b)NR.sup.b R.sup.b, (CH.sub.2).sub.r NHC (.dbd.NR.sup.b)NR.sup.b R.sup.b, (CH.sub.2).sub.r S(O).sub.p R.sup.c, (CH.sub.2).sub.r S(O).sub.2 NR.sup.b R.sup.b, (CH.sub.2).sub.r NR.sup.b S(O).sub.2 R.sup.c, and (CH.sub.2).sub.r phenyl;R.sup.b, at each occurrence, is selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl;R.sup.c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl;alternatively, R.sup.2 and R.sup.3 join to form a 5, 6, or 7-membered ring substituted with 0-3 R.sup.a ;R.sup.3 is selected from a (CR.sup.3 'R.sup.3"").sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.15 and a (CR.sup.3 'R.sup.3"").sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.15 ;R.sup.3' and R.sup.3"", at each occurrence, are selected from H, C.sub.1-6 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and phenyl;R.sup.4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, (CH.sub.2).sub.q C(O)R.sup.4b, (CH.sub.2).sub.q C(O)NR.sup.4a R.sup.4a', (CH.sub.2).sub.q C(O)OR.sup.4b, and a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.4c ;R.sup.4a and R.sup.4a', at each occurrence, are selected from H, C.sub.1-6 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and phenyl;R.sup.4b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, C.sub.2-8 alkynyl, and phenyl;R.sup.4c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.4a R.sup.4a', and (CH.sub.2).sub.r phenyl;alternatively, R.sup.4 joins with R.sup.7, R.sup.9, or R.sup.11 to form a 5, 6 or 7 membered piperidinium spirocycle or pyrrolidinium spirocycle substituted with 0-3 R.sup.a ;R.sup.5 is selected from a (CR.sup.5' R.sup.5"").sub.t -C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.16 and a (CR.sup.5' R.sup.5"").sub.t -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.16 ;R.sup.5' and R.sup.5"", at each occurrence, are selected from H, C.sub.1-6 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and phenyl;R.sup.6, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, (CF.sub.2).sub.r CF.sub.3, CN, (CH.sub.2).sub.r NR.sup.6a R.sup.6a', (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OR.sup.6b, (CH.sub.2).sub.r SH, (CH.sub.2).sub.r SR.sup.6b, (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.6b, (CH.sub.2).sub.r C(O)NR.sup.6a R.sup.6a', (CH.sub.2).sub.r NR.sup.6d C(O) R.sup.6a, (CH.sub.2).sub.r C(O) OR.sup.6b, (CH.sub.2).sub.r OC(O)R.sup.6b, (CH.sub.2).sub.r S(O).sub.p R.sup.6b, (CH.sub.2).sub.r S(O).sub.2 NR.sup.6a R.sup.6a', (CH.sub.2).sub.r NR.sup.6d S(O).sub.2 R.sup.6b, and (CH.sub.2).sub.t phenyl substituted with 0-3 R.sup.6c ;R.sup.6a and R.sup.6a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl substituted with 0-3 R.sup.6c ;R.sup.6b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl substituted with 0-3 R.sup.6c ;R.sup.6c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, and (CH.sub.2).sub.r NR.sup.6d R.sup.6d ;R.sup.6d, at each occurrence, is selected from H, C.sub.1-6 alkyl, and C.sub.3-6 cycloalkyl;with the proviso that when any of J, K, or L is CR.sup.6 R.sup.6 and R.sup.6 is halogen, cyano, nitro, or bonded to the carbon to which it is attached through a heteroatom, the other R.sup.6 is not halogen, cyano, or bonded to the carbon to which it is attached through a heteroatom;R.sup.7, is selected from H, C.sub.l-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.q OH, (CH.sub.2).sub.q SH, (CH.sub.2).sub.q OR.sup.7d, (CH.sub.2).sub.q SR.sup.7d, (CH.sub.2).sub.q NR.sup.7a R.sup.7a', (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.7b, (CH.sub.2).sub.r C(O)NR.sup.7a R.sup.7a', (CH.sub.2).sub.q NR.sup.7a C(O)R.sup.7a, (CH.sub.2).sub.q NR.sup.7a C(O)H, (CH.sub.2).sub.r C(O)OR.sup.7b, (CH.sub.2).sub.q OC(O)R.sup.7b, (CH.sub.2).sub.q S(O).sub.p R.sup.7b, (CH.sub.2).sub.q S(O).sub.2 NR.sup.7a R.sup.7a', (CH.sub.2).sub.q NR.sup.7a S(O).sub.2 R.sup.7b, C.sub.1-6 haloalkyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.7c, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.7c ;R.sup.7a and R.sup.7a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.7e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.7e ;R.sup.7b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-6 carbocyclic residue substituted with 0-2 R.sup.7e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.7e ;R.sup.7c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, (CF.sub.2).sub.r CF.sub.3, NO.sub.2, CN, (CH.sub.2).sub.r NR.sup.7f R.sup.7f, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OC.sub.1-4 alkyl, (CH.sub.2).sub.r SC.sub.1-4 alkyl, (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.7b, (CH.sub.2).sub.r C(O)NR.sup.7f R.sup.7f, (CH.sub.2).sub.r NR.sup.7f C(O)R.sup.7a, (CH.sub.2).sub.r C(O)OC.sub.1-4 alkyl, (CH.sub.2).sub.r OC(O) R.sup.7b, (CH.sub.2).sub.r C(.dbd.NR.sup.7f)NR.sup.7f R.sup.7f, (CH.sub.2).sub.r S(O).sub.p R.sup.7b, (CH.sub.2).sub.r NHC(.dbd.NR.sup.7f)NR.sup.7f R.sup.7f, (CH.sub.2).sub.r S(O).sub.2 NR.sup.7f R.sup.7f, (CH.sub.2).sub.r NR.sup.7f S(O).sub.2 R.sup.7b, and (CH.sub.2).sub.r phenyl substituted with 0-3 R.sup.7e ;R.sup.7d, at each occurrence, is selected from C.sub.1-6 alkyl substituted with 0-3 R.sup.7e, alkenyl, alkynyl, and a C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.7c ;R.sup.7e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.7f R.sup.7f, and (CH.sub.2).sub.r phenyl;R.sup.7f, at each occurrence, is selected from H, C.sub.1-6 alkyl, and C.sub.3-6 cycloalkyl;R.sup.8 is selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and (CH.sub.2).sub.r phenyl substituted with 0-3 R.sup.8a ;R.sup.8a, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.7f R.sup.7f, and (CH.sub.2).sub.r phenyl;alternatively, R.sup.7 and R.sup.8 join to form C.sub.3-7 cycloalkyl, or .dbd.NR.sup.8b ;R.sup.8b is selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, OH, CN, and (CH.sub.2).sub.r -phenyl;R.sup.9, is selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, F, Cl, Br, I, NO.sub.2, CN, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r SH, (CH.sub.2).sub.r OR.sup.9d, (CH.sub.2).sub.r SR.sup.9d, (CH.sub.2).sub.r NR.sup.9a R.sup.9a', (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.9b, (CH.sub.2).sub.r C(O)NR.sup.9a R.sup.9a', (CH.sub.2).sub.r NR.sup.9a C(O)R.sup.9a, (CH.sub.2).sub.r NR.sup.9a C(O)H, (CH.sub.2).sub.r NR.sup.9a C(O)NHR.sup.9a, (CH.sub.2).sub.r C(O)OR.sup.9b, (CH.sub.2).sub.r OC(O)R.sup.9b, (CH.sub.2).sub.r OC(O)NHR.sup.9a, (CH.sub.2).sub.r S(O).sub.p R.sup.9b, (CH.sub.2).sub.r S(O).sub.2 NR.sup.9a R.sup.9a', (CH.sub.2).sub.r NR.sup.9a S(O).sub.2 R.sup.9b, C.sub.1-6 haloalkyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.9c, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.9c ;R.sup.9a and R.sup.9a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-9 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.9e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.9e ;R.sup.9b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-6 carbocyclic residue substituted with 0-2 R.sup.9e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.9e ;R.sup.9c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, (CF.sub.2).sub.r CF.sub.3, NO.sub.2, CN, (CH.sub.2).sub.r NR.sup.9f R.sup.9f, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OC.sub.1-4 alkyl, (CH.sub.2).sub.r SC.sub.1-4 alkyl, (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(o)R.sup.9b, (CH.sub.2).sub.r C(O)NR.sup.9f R.sup.9f, (CH.sub.2).sub.r NR.sup.9f C(O)R.sup.9a, (CH.sub.2).sub.r C(O)OC.sub.1-4 alkyl, (CH.sub.2).sub.r OC(O)R.sup.9b, (CH.sub.2).sub.r C(.dbd.NR.sup.9f)NR.sup.9f R.sup.9f, (CH.sub.2).sub.r S(O).sub.p R.sup.9b, (CH.sub.2).sub.r NHC(.dbd.NR.sup.9f)NR.sup.9f R.sup.9f, (CH.sub.2).sub.r S(O).sub.2 NR.sup.9f R.sup.9f, (CH.sub.2).sub.r NR.sup.9f S(O).sub.2 R.sup.9b, and (CH.sub.2).sub.r phenyl substituted with 0-3 R.sup.9e ;R.sup.9d, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, a C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.9c, and a 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.9c ;R.sup.9e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.9f R.sup.9f, and (CH.sub.2).sub.r phenyl;R.sup.9f, at each occurrence, is selected from H, C.sub.1-6 alkyl, and C.sub.3-6 cycloalkyl;R.sup.10, is selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, F, Cl, Br, I, NO.sub.2, CN, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OR.sup.10d, (CH.sub.2).sub.r SR.sup.10d, (CH.sub.2).sub.r NR.sup.10a R.sup.10a', (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.10b, (CH.sub.2).sub.r C(O)NR.sup.10a R.sup.10a', (CH.sub.2).sub.r NR.sup.10a C(O)R.sup.10a, (CH.sub.2).sub.r NR.sup.10a C(O)H, (CH.sub.2).sub.r C(O)OR.sup.10b, (CH.sub.2).sub.r OC(O)R.sup.10b, (CH.sub.2).sub.r S(O).sub.p R.sup.10b, (CH.sub.2).sub.r S(O).sub.2 NR.sup.10a R.sup.10a', (CH.sub.2).sub.r NR.sup.10a S(O).sub.2 R.sup.10b, C.sub.1-6 haloalkyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.10c, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.10c ;R.sup.10a and R.sup.10a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.10e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.10e ;R.sup.10b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-6 carbocyclic residue substituted with 0-2 R.sup.10e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.10e ;R.sup.10c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, (CF.sub.2).sub.r CF.sub.3, NO.sub.2, CN, (CH.sub.2).sub.r NR.sup.10f R.sup.10f, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OC.sub.1-4 alkyl, (CH.sub.2).sub.r SC.sub.1-4 alkyl, (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.10b, (CH.sub.2).sub.r C(O)NR.sup.10f R.sup.10f, (CH.sub.2).sub.r NR.sup.10f C(O)R.sup.10a, (CH.sub.2).sub.r C(O)OC.sub.1-4 alkyl, (CH.sub.2).sub.r OC(O)R.sup.10b, (CH.sub.2).sub.r C(.dbd.NR.sup.10f)NR.sup.10f R.sup.10f, (CH.sub.2).sub.r S(O).sub.p R.sup.10b, (CH.sub.2).sub.r NHC(.dbd.NR.sup.10f)NR.sup.10f R.sup.10f, (CH.sub.2).sub.r S(O).sub.2 NR.sup.10f R.sup.10f, (CH.sub.2).sub.r NR.sup.10f S(O).sub.2 R.sup.10b, and (CH.sub.2).sub.r phenyl substituted with 0-3 R.sup.10c ;R.sup.10d, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, a C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.10c, and a 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.10c ;R.sup.10e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.10f R.sup.10f, and (CH.sub.2).sub.r phenyl;R.sup.10f, at each occurrence, is selected from H, C.sub.1-6 alkyl, and C.sub.3-6 cycloalkyl;alternatively, R.sup.9 and R.sup.10 join to form C.sub.3-7 cycloalkyl, 5-6-membered cyclic ketal, or .dbd.O;with the proviso that when R.sup.10 is halogen, cyano, nitro, or bonded to the carbon to which it is attached through a heteroatom, R.sup.9 is not halogen, cyano, or bonded to the carbon to which it is attached through a heteroatom;R.sup.11, is selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.q OH, (CH.sub.2).sub.q SH, (CH.sub.2).sub.q OR.sup.11d, (CH.sub.2).sub.q SR.sup.11d, (CH.sub.2).sub.q NR.sup.11a R.sup.11a', (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.11b, (CH.sub.2).sub.r C(O) NR.sup.11a R.sup.11a', (CH.sub.2).sub.q NR.sup.11a C(O)R.sup.11a, (CH.sub.2).sub.q NR.sup.11a C(O)NHR.sup.11a, (CH.sub.2).sub.r C(O)OR.sup.11b, (CH.sub.2).sub.q OC(O)R.sup.11b, (CH.sub.2).sub.q S(O).sub.p R.sup.11b, (CH.sub.2).sub.q S(O).sub.2 NR.sup.11a R.sup.11a', (CH.sub.2).sub.q NR.sup.11a S(O).sub.2 R.sup.11b, C.sup.1-6 haloalkyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.11c, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.11c ;R.sup.11a and R.sup.11a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.11e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.11e ;R.sup.11b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-6 carbocyclic residue substituted with 0-2 R.sup.11e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.11e ;R.sup.11c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, (CF.sub.2).sub.r CF.sub.3, NO.sub.2, CN, (CH.sub.2).sub.r NR.sup.11f R.sup.11f, (CH.sub.2).sub.r OH, (CH.sub.2).sub.r OC.sub.1-4 alkyl, (CH.sub.2).sub.r SC.sub.1-4 alkyl, (CH.sub.2).sub.r C(O)OH, (CH.sub.2).sub.r C(O)R.sup.11b, (CH.sub.2).sub.r C(O)NR.sup.11f R.sup.11f, (CH.sub.2).sub.r NR.sup.11f C(O)R.sup.11a, (CH.sub.2).sub.r C(O)OC.sub.1-4 alkyl, (CH.sub.2).sub.r OC(O)R.sup.11b, (CH.sub.2).sub.r C(.dbd.NR.sup.11f)NR.sup.11f R.sup.11f, (CH.sub.2).sub.r NHC(.dbd.NR.sup.11f)NR.sup.11f R.sup.11f, (CH.sub.2).sub.r S(O).sub.p R.sup.11b, (CH.sub.2).sub.r S(O).sub.2 NR.sup.11f R.sup.11f, (CH.sub.2).sub.r NR.sup.11f S(O).sub.2 R.sup.11b, and (CH.sub.2).sub.r phenyl substituted with 0-3 R.sup.11e ;R.sup.11d, at each occurrence, is selected from C.sub.1-6 alkyl substituted with 0-3 R.sup.11e, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, and a C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.11c ;R.sup.11e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.11f R.sup.11f, and (CH.sub.2).sub.r phenyl;R.sup.11f, at each occurrence, is selected from H, C.sub.1-6 alkyl, and C.sub.3-6 cycloalkyl;R.sup.12 is selected from H, C.sub.1-6 alkyl, (CH.sub.2).sub.q OH, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and (CH.sub.2).sub.t phenyl substituted with 0-3 R.sup.12a ;R.sup.12a, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.9f R.sup.9f, and (CH.sub.2).sub.r phenyl;alternatively, R.sup.11 and R.sup.12 join to form C.sub.3-7 cycloalkyl;R.sup.13, at each occurrence, is selected from (CHR.sup.13a)OH, (CHR.sup.13a)OR.sup.13b, (CHR.sup.13a)SH, (CHR.sup.13a)SR.sup.13b, (CHR.sup.13a)NR.sup.13e C(O)R.sup.13f, and (CHR.sup.13a) NR.sup.13e S(O).sub.2 R.sup.13f ;R.sup.13a is selected from C.sub.17 alkyl;R.sup.13b, at each occurrence, is selected from C(O)R.sup.13d, C(O)NHR.sup.13d, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl substituted with 0-3 R.sup.13c ;R.sup.13c, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.9f R.sup.9f, and (CH.sub.2).sub.r phenyl;R.sup.13d, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl substituted with 0-3 R.sup.6c ;R.sup.13e, at each occurrence, is selected from H, C.sub.1-6 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and phenyl where phenyl is substituted from 0-3 R.sup.13c ;R.sup.13f, at each occurrence, is selected from C.sub.1-6 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, CF.sub.3, and phenyl where phenyl is substituted from 0-3 R.sup.13c ;R.sup.15, at each occurrence, is independently selected from C.sub.1-8 alkyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, NO.sub.2, CN, (CHR').sub.r NR.sup.15a R.sup.15a', (CHR').sub.r OH, (CHR').sub.r O(CHR').sub.r R.sup.15d, (CHR').sub.r SH, (CHR').sub.r C(O)H, (CHR).sub.r S(CHR').sub.r R.sup.15d, (CHR').sub.r C(O)OH, (CHR').sub.r C(O)(CHR').sub.r R.sup.15b, (CHR').sub.r C(O)NR.sup.15a R.sup.15a', (CHR').sub.r NR.sup.15f C(O)(CHR').sub.r R.sup.15b, (CHR').sub.r NR.sup.15f C(O)NR.sup.15f R.sup.15f, (CHR').sub.r C(O)O(CHR').sub.r R.sup.15d, (CHR').sub.r OC(O)(CHR').sub.r R.sup.15b, (CHR').sub.r C(.dbd.NR.sup.15f)NR.sup.15a R.sup.15a', (CHR').sub.r NHC(.dbd.NR.sup.15f)NR.sup.15f R.sup.15f, (CHR').sub.r S(O).sub.p (CHR').sub.r R.sup.15b, (CHR').sub.r S(O).sub.2 NR.sup.15a R.sup.15a', (CHR').sub.r NR.sup.15f S(O).sub.2 (CHR').sub.r R.sup.15b, C.sub.1-6 haloalkyl, C.sub.2-8 alkenyl substituted with 0-3 R', C.sub.2-8 alkynyl substituted with 0-3 R', (CHR').sub.r phenyl substituted with 0-3 R.sup.15e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.15e ;R', at each occurrence, is selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, and (CH.sub.2).sub.r phenyl substituted with R.sup.15e ;R.sup.15a and R.sup.15a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.15e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.15e ;R.sup.15b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-6 carbocyclic residue substituted with 0-3 R.sup.15e, and (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.15e ;R.sup.15d, at each occurrence, is selected from C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-6 alkyl substituted with 0-3 R.sup.15e, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.15e, and a (CH.sub.2).sub.r 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.15e ;R.sup.15e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.15f R.sup.15f, and (CH.sub.2).sub.r phenyl;R.sup.15f, at each occurrence, is selected from H, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, and phenyl;R.sup.16, at each occurrence, is selected from C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, Br, I, F, NO.sub.2, CN, (CHR').sub.r NR.sup.16a R.sup.16a', (CHR').sub.r OH, (CHR').sub.r O(CHR').sub.r R.sup.16d, (CHR').sub.r SH, (CHR').sub.r C(O)H, (CHR').sub.r S(CHR').sub.r R.sup.6d, (CHR').sub.r C(O)OH, (CHR').sub.r C(O)(CHR').sub.r R.sup.16b, (CHR').sub.r C(O)NR.sup.16a R.sup.16a', (CHR').sub.r NR.sup.16f C(O)(CHR').sub.r R.sup.16b, (CHR').sub.r C(O)O(CHR').sub.r R.sup.16d, (CHR').sub.r OC(O)(CHR').sub.r R.sup.16b, (CHR').sub.r C (.dbd.NR.sup.16f)NR.sup.16a R.sup.16a', (CHR').sub.r NHC(.dbd.NR.sup.16f)NR.sup.16f R.sup.16f, (CHR').sub.r S(O).sub.p (CHR').sub.r R.sup.16b, (CHR').sub.r S(O).sub.2 NR.sup.16a R.sup.16a', (CHR').sub.r NR.sup.16f S(O).sub.2 (CHR').sub.r R.sup.16b, C.sub.1-6 haloalkyl, C.sub.2-8 alkenyl substituted with 0-3 R', C.sub.2-8 alkynyl substituted with 0-3 R', and (CHR').sub.r phenyl substituted with 0-3 R.sup.16e ;R.sup.16a and R.sup.16a', at each occurrence, are selected from H, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-5 R.sup.16e, and a (CH.sub.2).sub.r -5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.16e ;R.sup.16b, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, a (CH.sub.2).sub.r C.sub.3-6 carbocyclic residue substituted with 0-3 R.sup.16e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R.sup.16e ;R.sup.16d, at each occurrence, is selected from C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-6 alkyl substituted with 0-3 R.sup.16e, a (CH.sub.2).sub.r --C.sub.3-10 carbocyclic residue substituted with 0-3 R.sup.16e, and a (CH.sub.2).sub.r -5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R.sup.16e ;R.sup.16e, at each occurrence, is selected from C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (CH.sub.2).sub.r C.sub.3-6 cycloalkyl, Cl, F, Br, I, CN, NO.sub.2, (CF.sub.2).sub.r CF.sub.3, (CH.sub.2).sub.r OC.sub.1-5 alkyl, OH, SH, (CH.sub.2).sub.r SC.sub.1-5 alkyl, (CH.sub.2).sub.r NR.sup.16f R.sup.16f, and (CH.sub.2).sub.r phenyl;R.sup.16f, at each occurrence, is selected from H, C.sub.1-5 alkyl, and C.sub.3-6 cycloalkyl, and phenyl;v is selected from 0, 1, and 2;t is selected from 1 and 2;w is selected from 0 and 1;r is selected from 0, 1, 2, 3, 4, and 5;q is selected from 1, 2, 3, 4, and 5; andp is selected from 0, 1, 2, and 3.