Patent ID: 7148014
Filing Date: 2006-12-12
Classification: A61K,C07K,C12N

Abstract:
1. A method of inhibiting the phagocytic potential of a mammalian monocyte expressing an FcγRIIA receptor comprising introducing into said monocyte a construct comprising, in the 5′-3′ direction of transcription: i) a promoter functional in said monocyte, ii) a segment of a double-stranded DNA wherein the transcribed strand of said segment comprises a sequence complementary to endogenous mRNA encoding said FcγRIIA receptor, and iii) a termination sequence functional in said monocyte, wherein said construct is introduced under conditions such that said complementary strand is transcribed and binds to said endogenous mRNA thereby reducing expression of said FcγRIIA receptor and inhibiting the phagocytic potential of said monocyte.