Patent ID: 9102724
Filing Date: 2015-08-11
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an isolated anti-FZD10 antibody that is selected from the group consisting of: (a) an isolated antibody, or an antigen-binding fragment thereof, that binds to human FZD10, comprising a heavy chain variable region comprising the VHCDR1, VHCDR2 and VHCDR3 amino acid sequences set forth in SEQ ID NOs:5, 6 and 7, respectively, and a light chain variable region comprising the VLCDR1, VLCDR2 and VLCDR3 amino acid sequences set forth in: SEQ ID NOs:9, 11, 12, respectively, or SEQ ID NOs:10, 11, 12, respectively; (b) the isolated antibody, or an antigen-binding fragment thereof, of (a), wherein the heavy chain variable region comprises the VHCDR1, VHCDR2 and VHCDR3amino acid sequences set forth in SEQ ID NOs:5, 6, and 7, respectively, and the light chain variable region comprises the VLCDR1, VLCDR2 and VLCDR3 amino acid sequences set forth in SEQ ID NOs:9, 11, and 12, respectively; (c) the isolated antibody, or an antigen-binding fragment thereof, of (b), wherein he light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:3; (d) the isolated antibody, or an antigen-binding fragment thereof, of (b), wherein the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:1; (e) the isolated antibody, or an antigen-binding fragment thereof, of (a), wherein the heavy chain variable region comprises the VHCDR1, VHCDR2 and VHCDR3 amino acid sequences set forth in SEQ ID) NOs:5, 6, and 7, respectively, and the light chain variable region comprises the VLCDR1, VLCDR2 and VLCDR3 amino acid sequences set forth in SEQ ID NOs:10, 11, and 12, respectively; (f) the isolated antibody, or an antigen-binding fragment thereof, of (e), wherein the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:1; (g) the isolated antibody, or an antigen-binding fragment thereof, of (e), wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:4; (h) the isolated antibody, or an antigen-binding fragment thereof, of (a) wherein the antibody is humanized; (i) the isolated antibody, or antigen-binding fragment thereof, of (h) wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:37; (j) the isolated antibody, or antigen-binding fragment thereof, of (i), further comprising a heavy chain variable region that comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ NO:39; (k) the isolated antibody, or antigen-binding fragment thereof, of (i), further comprising a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO:39; (l) the isolated antibody, or antigen-binding fragment thereof, of (k), further comprising a human lambda light chain constant region comprising the amino acid sequence set forth in SEQ ID NO:36; (m) the isolated antibody, or antigen-binding fragment thereof, of (l), further comprising a human IgGl constant region comprising the amino acid sequence set forth in SEQ ID NO:34; and (n) the isolated antibody, or antigen-binding fragment thereof, of (h), wherein the isolated antibody comprises a light chain comprising the amino acid sequence set forth in SEQ ID NO:29 and a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:31,