Patent ID: 8147824
Filing Date: 2012-04-03
Classification: A61K,A61N,A61P,C12N

Abstract:
1. A method of suppressing GVHD in a subject, comprising: suppressing GVHD in a subject by administering to a subject by an effective route and in an effective amount to suppress GVHD, isolated, expanded human multipotent non-embryonic, non-germ cells that can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal embryonic lineages, express telomerase, do not provoke a deleterious immune response in the subject, have undergone at least 10-40 cell doublings in culture prior to administration, and are effective to suppress GVHD, wherein the cells are administered adjunctively to transplantation.