Patent ID: 7517532
Filing Date: 2009-04-14
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein R 1 is —C 1-4 alkyl mono-substituted with aryl; wherein the aryl is optionally substituted with from 1 to 4 substituents each of which is independently (1) —C (2) —O—C (3) —C (4) —O—C (5) —OH, (6) halo, (7) —CN, (8) —NO (9) —N(R (10) —SR (11) —S(═O)R (12) —SO (13) —N(R (14) —SO (15) —N(R (16) —N(R (17) phenyl; R 2 is —H or —C 1-6 alkyl; R 3 is —H, —C 1-6 alkyl, —C 1-6 haloalkyl, or —C 1-6 alkyl substituted with one of —OH, —O—C 1-6 alkyl, —O—C 1-6 haloalkyl, —CN, —NO 2 , —N(R a R b ), —C(═O)N(R a R b ), —C(═O)R a , —CO 2 R c , —S(O) n R c , —SO 2 N(R a R b ), —N(R a )C(═O)R b , —N(R a )CO 2 R c , —N(R a )SO 2 R c , —N(R a )SO 2 N(R a R b ), —OC(═O)N(R a R b ), or —N(R a )C(═O)N(R a R b ); R 4 is: (1) —H, (2) —C (3) —C (4) —C(═O)R (5) —CO (6) —C(═O)N(R (7) —SO (8) —C (9) —C (10) —C (11) —C (12) —C (13) —C (14) —R (15) —C (16) —C (17) —C (18) —C (19) —C (20) —C (21) —C (22) —C (23) —C (24) —C (25) —C (26) —C (27) —C (28) —C or alternatively R 3 and R 4 are joined together to form C 5-8 cycloalkyl or a 5- to 7-membered saturated heterocyclic ring containing from 1 to 4 heteroatoms independently selected from N, O and S; wherein R 5 is: (1) —H, (2) —C (3) —C (4) —C (5) —C (6) —C (7) —C (8) —C (9) —C (10) —C (11) —C (12) —O—C (13) —O—C (14) halo, (15) —CN, (16) —C(═O)R (17) —CO (18) —SR (19) —S(═O)R (20) —SO (21) —N(R (22) —C(═O)N(R (23) —SO (24) aryl (25) —C (26) HetB, (27) —C (28) HetC, or (29) —C wherein each aryl is independently phenyl or naphthyl; each R a and R b is independently —H or —C 1-6 alkyl; each R c is independently a —C 1-6 alkyl; R d is a —C 1-6 alkyl, allyl, or benzyl; and each n is independently an integer equal to 0, 1 or 2.