Patent ID: 8257741
Filing Date: 2012-09-04
Classification: A61J,A61K,A61P,B01J

Abstract:
1. A process for making a solid dispersion consisting of a sparingly water-soluble drug and hydroxypropyl methyl cellulose acetate succinate (HPMCAS), said drug being molecularly dispersed and amorphous in said dispersion, said process consisting essentially of the steps of: (a) providing a solution consisting of a sparingly water-soluble drug, HPMCAS, and a solvent, said solvent being an organic compound in which said drug and HPMCAS are mutually soluble, said solution having a ratio of said drug to HPMCAS of from 1 to 0.4 to 1 to 20; (b) breaking up said solution into small droplets, wherein said droplets range in size from 1 to 500 μm; (c) directing said droplets and a drying gas into a drying chamber to cause evaporation of a sufficient amount of said solvent from said droplets to cause solidification of said droplets in less than 5 seconds to form said solid dispersion wherein said drug has a dose to aqueous solubility ratio greater than 100 mL.