Patent ID: 6015921
Filing Date: 2000-01-18
Classification: C07C

Abstract:
A method for preparing a carbamoylmethylurea derivative of the formula (I): ##STR13## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is a hydrogen or --CH.sub.2 COR.sub.5 (R.sub.5 is lower alkoxy, lower alkylamino, cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic group); R.sub.3 is an optionally substituted phenyl; R.sub.4 is an optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted alkyl or optionally substituted heterocyclic group, which comprises reacting a carboxymethylurea derivative of the formula (II): ##STR14## wherein R.sub.1 and R.sub.3 are as defined above or a reactive derivative thereof, with an aniline derivative of the formula (III): ##STR15## where R.sub.2 and R.sub.4 are as defined above.