Patent ID: 7498300
Filing Date: 2009-03-03
Classification: A61K,A61P,C07K

Abstract:
1. A 38-residue or 39-residue CRF cyclic peptide, or a nontoxic salt thereof, which binds to CRFR1 with an affinity substantially greater than it binds to CRFR2, which peptide has the following formula: wherein the sidechains of Glu and Lys indicated are covalently linked; Y 1 is an acyl group having not more than 15 carbon atoms or is radioiodinated tyrosine; R 14 is CML or Leu; R 15 is CML or Leu; R 17 is Glu or CML; R 18 is Val or CML; R 19 is CML or Leu; R 27 is CML or Leu; R 32 is His or D-His; R 33 is Aib, D-Ala, D-Ser or Ser; R 36 is Lys or CML; R 37 is CML or Leu; R 40 is Ile or CML; and R 41 is Ile or CML; provided that D-β-(2-napthyl)alanine(D-2Nal) or D-Leu may be substituted for D-Phe.