Patent ID: 6211244
Filing Date: 2001-04-03
Classification: A61K,A61P,C07C,C07D,G01N

Abstract:
A compound having the formula: ##STR15##wherein Ar.sub.5 is either naphthyl or phenyl optionally substituted with 0 to 5 substituents each independently selected from the group consisting of, lower alkyl, halogen, lower alkoxy, lower thioalkyl, methylene dioxy, lower haloalkyl, lower haloalkoxy, OH, CH.sub.2 OH, CONH.sub.2, CN, acetoxy, benzyl, benzyloxy, .alpha.,.alpha.-dimethylbenzyl, NO.sub.2, CHO, CH.sub.3 CH(OH), acetyl, ethylene dioxy, and --CH.dbd.CH-phenyl;Ar.sub.6 is phenyl substituted with 1 to 5 substituents each independently selected from the group consisting of acetyl, lower alkyl, halogen, lower alkoxy, lower thioalkyl, methylene dioxy, lower haloalkyl, lower haloalkoxy, OH, CH.sub.2 OH, CONH.sub.2, CN, carbomethoxy, OCH.sub.2 C(O)C.sub.2 H.sub.5 and OCH.sub.2 C(O)OC.sub.2 H.sub.5 and acetoxy, provided that at least one substituent is OCH.sub.2 C(O)OC.sub.2 H.sub.5 ;R.sub.11 is hydrogen or methyl; andR.sub.12 is hydrogen or methyl;provided that at least one of R.sub.11 and R.sub.12 is methyl; or a pharmaceutically acceptable salt or complex thereof.