Patent ID: 6278893
Filing Date: 2001-08-21
Classification: A61K,G01R

Abstract:
A method of magnetic resonance investigation of a sample, said method comprising:i) subjecting a high T.sub.1 agent to ex vivo polarisation and where this is carried out by means of a polarising agent, optionally separating the whole, or a portion of said polarising agent from said high T.sub.1 agent;ii) administering said high T.sub.1 agent to said sample;iii) exposing said sample to a radiation of a frequency selected to excite nuclear spin transitions in selected nuclei;iv) detecting magnetic resonance signals from said sample; andv) optionally, generating an image, dynamic flow date, diffusion data, perfusion data, physiological data or metabolic data from said detected signals,wherein said high T.sub.1 agent is a solid high T.sub.1 agent comprising nuclei selected from the group consisting of .sup.1 H, .sup.3 L.sub.i, .sup.13 C, .sup.15 N, .sup.19 F and .sup.31 P nuclei and wherein said solid high T.sub.1 agent is dissolved in an administrable media prior to administration to said sample.