Patent ID: 6309687
Filing Date: 2001-10-30
Classification: A23L,A61K,C07D

Abstract:
A method for preparing an edible product providing reliable first-pass effect inhibiting activity, comprising adding a compound of Formulae I-IV to a natural or commercial edible product: ##STR16##wherein in each of the above structures, R is, independently, H or an optionally substituted C.sub.1 -C.sub.15 alkyl group,L is an optionally substituted C.sub.1 -C.sub.15 linear or branched, saturated, monounsaturated or polyunsaturated alkyl group optionally terminated at one or both ends by oxygen,HAr is an optionally substituted C.sub.6 -C.sub.24 aromatic group or heteroaromatic group optionally containing one or plural ring atoms selected from the group consisting of N, O, S, and P,and E is --OH, --COOH, --COOR where R is defined above or an optionally substituted C.sub.1 -C.sub.8 linear or branched, saturated, monounsaturated or polyunsaturated alkyl group optionally interrupted by one or plural nonadjacent oxygen or sulphur atoms, or E is a C.sub.3 -C.sub.8 optionally substituted cyclic saturated, monounsaturated or polyunsaturated alkyl group optionally interrupted by one or plural nonadjacent oxygen or sulphur atoms, or E is optionally substituted HAr,wherein the optional substituents for the groups R, L, HAr and E are selected from the group consisting of a C.sub.1 -C.sub.6 linear, branched or cyclic alkyl group, --OH, halogen, a C.sub.1 -C.sub.5 alkoxy group, a C.sub.1 -C.sub.5 carbonyloxy group and a C.sub.1 -C.sub.5 alkoxycarbonyl group.