Patent ID: 8785448
Filing Date: 2014-07-22
Classification: A61K,A61N,A61P,C07D

Abstract:
1. A method for treating cell proliferative disorders caused by and/or associated with an altered cell cycle dependent kinase activity, the cell proliferative disorder selected from the group consisting of ovarian cancer, breast cancer, colon cancer, non-small cell lung cancer, small cell lung cancer and mesothelioma, the method comprising administering to a mammal in need thereof an effective amount of a compound represented by formula (Ib) wherein R is a group —COR R a) straight or branched C b) cycloalkyl, cycloalkyl-alkyl or alkyl-cycloalkyl wherein the cycloalkyl moiety comprises any C c) 3-methylthienyl-2-yl; 2-thienyl; phenyl; 2,6-difluorophenyl; 4-(aminosulfonyl)phenyl; 4-(dimethylaminomethyl)phenyl; 4-(4-methylpiperazinyl)methyl-phenyl; d) a group of formula (IIa) or (IIb): wherein, in formula (IIa), the cycle represents a 5 to 7 membered heterocyclic ring wherein X, directly linked to the rest of the molecule, represents a carbon or nitrogen atom; Y is a carbon, nitrogen, oxygen or sulfur atom or it is an NH group, provided that at least one of X and Y is other than a carbon atom; R e) a group of formula (IIc) or (IId): wherein R or a pharmaceutically acceptable salt thereof.