Patent ID: 6680337
Filing Date: 2004-01-20
Classification: A61K,A61P

Abstract:
A method of treating systemic hypertensive and pulmonary disease or gastrointestinal disease, reproduction, fertility, incontinence, shock, inflammation, immune regulation, disorder of bone metabolism, renal dysfunction, cancer and hyperproliferative disease which comprises administering to a mammal having one of said diseases a therapeutically effective amount of a compound represented by formula I wherein wavy line attachments indicate either the alpha (&agr;) or beta (&bgr;) configuration; dashed bonds represent a double bond or a single bond, R is a heteroaryl or a substituted heteroaryl radical, R1 is hydroxyl or hydrocarbyloxy or hetero atom substituted hydrocarbyloxy comprising up to 20 carbon atoms, X is selected from the group consisting of â€”OR6 and â€”N(R6)2 wherein R6 is selected from the group consisting of hydrogen, a lower alkyl radical having from 1 to 6 carbon atoms, R5â€”C(&boxH;O)â€” or R5â€”Oâ€”C(&boxH;O)â€” wherein R5 is a lower alkyl radical having from 1 to 6 carbon atoms and Y is &boxH;O or represents 2 hydrogen radicals and further provided at least one of R1 is a hydrocarbyloxy or heteroatom substituted hydrocarbyloxy or a pharmaceutically-acceptable salt thereof.