Patent ID: 6673901
Filing Date: 2004-01-06
Classification: C07K,C12N,C40B,G01N

Abstract:
A fibronectin type III (Fn3) polypeptide monobody comprising at least two Fn3 &bgr;-strand domain sequences with a loop region sequence linked between each Fn3 &bgr;-strand domain sequence,wherein at least one monobody loop region sequence varies as compared to the wild-type (SEQ ID NO:110, FIG. 2) loop region sequence by deletion of two to twelve amino acids in the loop region sequence, insertion of at least two to 25 amino acids, or replacement of at least two amino acids in the loop region sequence, and wherein the polypeptide monobody loop region comprises at least two amino acids and binds to a specific binding partner (SBP) to form a polypeptide:SBP complex.