Patent ID: 6270952
Filing Date: 2001-08-07
Classification: A61L,A61P

Abstract:
A method of quenching undesired side reactions of a pathogen inactivating compound in a blood product, the method comprising:treating the blood product with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which forms, an electrophilic group;wherein the pathogen inactivating compound does not require photoactivation to inactivate a pathogen; andtreating the blood product with a quencher comprising a nucleophilic group that can covalently react with the electrophilic group, wherein the quencher is present in an amount sufficient to reduce the level of side reactions and wherein the pathogen inactivating compound penetrates the pathogen relative to the quencher in an amount capable of inactivating the pathogen before it is quenched.