Patent ID: 7129250
Filing Date: 2006-10-31
Classification: A61K,A61P,C07D

Abstract:
1. A pharmaceutically active pyrrolo-β-carboline derivative represented by formula (I): or a pharmaceutically acceptable salt thereof wherein: A B X X X X X R when X wherein X═O, S, or NH, and R 51 is H, R 52 and R 53 are independently chosen from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or R 51 and R 52 are combined to form a heteroalkyl, substituted heteroalkyl, heteroaryl, or substituted heteroaryl ring system; and wherein X═O, S, or NH, and R 51 is H, R 52 and R 53 are independently chosen from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or R 51 and R 52 are combined to form a heteroalkyl, substituted heteroalkyl, heteroaryl, or substituted heteroaryl ring system; wherein in formula I, when A with the proviso that 3-(1-benzimidazolyl)-4-(3-indolyl)-1H-pyrrole-2,5-dione is excluded.