Patent ID: 6416979
Filing Date: 2002-07-09
Classification: A61K

Abstract:
A process for producing a compound of formula or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently H, C2-C6 acyl or halo-substitute benzoyl; and R3 is â€”C(O)Oâ€”C1-C6 alkyl, C(O)OH, CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R2 is acetyl and R3 is methoxycarbonyl, R1 is not H; and that when R3 is CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, R1 and R2 are H, which comprises: cultivating Marasmiellus sp. FERM BP-5735, or a mutant or recombinant form thereof; and recovering said compound of formula (I).