Patent ID: 7914814
Filing Date: 2011-03-29
Classification: A61K,A61P,A61Q

Abstract:
1. A method of increasing localized bloodflow in tissue by delivering to skin an L-arginine derivative, the method comprising the step of: applying topically to the skin a delivery vehicle for the L-arginine derivative, said delivery vehicle comprising an amount of the L-arginine derivative effective to increase localized tissue bloodflow when combined with an agent for creating a hostile biophysical environment comprising an ionic salt mixture comprising choline chloride, sodium chloride, and magnesium chloride, the agent being at a concentration sufficient to create the hostile biophysical environment, the hostile biophysical environment causing the L-arginine derivative to migrate from the delivery vehicle to the skin where the L-arginine derivative is absorbed by tissue in the area surrounding the skin where the L-arginine derivative is applied.