Patent ID: 8962806
Filing Date: 2015-02-24
Classification: A61K,A61P,C07K

Abstract:
1. An isolated humanized monoclonal CC-chemokine receptor 4 (CCR4) antibody or fragment thereof, wherein said antibody has the following characteristics: a. binds to CCR4 positive (CCR4+) cells but not CCR4 negative (CCR4−) cells; b. decreases binding of a ligand or agonist to the CCR4 receptor; and i. a heavy chain variable region encoded by the nucleic acid sequence comprising:  or ii. a heavy chain variable region comprising the amino acid sequence: QVQLVQSGAEVKKPGASVKVSCKASGYTFASYYMHWMRQAPGQGLEWIGWINPGNVNTKYNEKFKGRATLTVDTSTNTAYMELSSLRSEDTAVYYCARS TYYRPLDYWGQGTLVTVSS (SEQ ID NO:2); and iii. a light chain variable region encoded by the nucleic acid sequence comprising:  or iv. a light chain variable region comprising the amino acid sequence: