Patent ID: 6504031
Filing Date: 2003-01-07
Classification: C07B,C07C,C07D

Abstract:
A compound of formula (Ia): whereinR2 is selected from the group consisting of hydrogen, halo, alkyl, alkenyl, alkynyl, alkoxyalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkyl, and â€”NRaRb, wherein Ra and Rb are independently selected from the group consisting of hydrogen, aryl, and heteroaryl; and R3 is wherein R4and R5 are on adjacent carbons and, taken together with the carbon atoms to which they are attached, are pyridine or a nitrogen-containing heterocycloalkyl, wherein the groups defining R3 can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, hydroxy, hydroxyalkyl, aryl, arylalkyl, alkanoyl, alkoxycarbonyl, alkenyl, alkynyl, halo, haloalkyl, heteroaryl, heteroarylalkyl, and a nitrogen-protecting group; and Rf is cyano or â€”C(&boxH;NR1)NH2, wherein R1 is hydrogen or hydroxy.