Patent ID: 6486313
Filing Date: 2002-11-26
Classification: C07H

Abstract:
A process of preparing an alkylphosphonate compound of the structure: whereineach M1 and M2 independently, are hydrogen or a hydroxyl protecting group or one of M1 and M2 is hydrogen or a hydroxyl protecting group and the other of M1 and M2 is a covalent attachment to a solid support; each J is, independently, hydrogen, a 2â€²-substituent group, or a protected 2â€²-substituent group; R1 is an electron withdrawing group; X2 is hydrogen or â€”(CH2)mâ€”E2; E2 is hydrogen, alkyl, aryl, aralkyl, substituted aryl, a heterocycle, mixed heterocycle or heteroaryl; m is 0, 1, 2 or 3; and Bx is a heterocyclic base moiety; â€ƒcomprising the steps of: a) selecting a dimeric trialkylphosphite compound of the structure: â€ƒand b) treating said dimeric trialkylphosphite compound, in a solvent, with a base under conditions of time temperature and pressure to form said alkylphosphonate compound.