Patent ID: 8445023
Filing Date: 2013-05-21
Classification: A61K,A61P

Abstract:
1. A method of preparing a pharmaceutical formulation for combating the misuse of active principle (AP), the method comprising: providing inert cores; coating the inert cores with at least one layer comprising the active principle; coating the at least one layer comprising the active principle with at least one coating layer (Ra) to create modified release coated microparticles resistant to crushing; wherein said at least one coating layer (Ra) represents a fraction by weight (Tp) greater than 30%, expressed in % by dry weight, based on the total weight of the coated microparticles, whereby said at least one coating layer (Ra) comprises: wherein said formulation further comprises at least one viscosifier (Vb) whereby said formulation further comprises at least one AP sequestering agent Q, whereby a complex with the AP is formed in solution.