Patent ID: 6046197
Filing Date: 2000-04-04
Classification: A61P,C07D

Abstract:
A compound of Formula (I): ##STR5## R.sub.1 is independently hydrogen, NH.sub.2, OH, SH, CN, CO.sub.2 H or hydrogen;R.sub.2 is independently hydrogen, C.sub.1-4 alkylC(O)R.sub.5, C.sub.1-4 alkyl or R.sub.2 is benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, C1, I, Br, OH, or N(R.sub.4).sub.2 ;R.sub.3 is independently hydrogen, C.sub.1-5 alkyl, C.sub.1-5 alkylenehydroxy, C.sub.1-5 alkyleneCO.sub.2 H,(CH.sub.2).sub.y N(R.sub.4).sub.2, (CH.sub.2).sub.m C(O)N(R.sub.4).sub.2, C.sub.1-5 alkyleneSH, CH.sub.2 Ar, ##STR6## R.sub.4 is independently hydrogen, C.sub.1-5 alkyl or benzyl; Ar is independently phenyl or indolyl optionally substituted by one or two R.sub.7 groups;Q is bicyclo[3.3.0]octanyl, xylyl, benzophenonyl or 1,2,3,4-tetrahydronaphthyl; all of which are unsubstituted or substituted by one or two substituents chosen from: C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, mono or di C.sub.1-4 alkylamino, or --(CH.sub.2).sub.n --COR.sub.6 ;R.sub.5 is --OR.sub.6, --N(R.sub.6).sub.2, or --SR.sub.6 ;R.sub.6 is hydrogen, C.sub.1-4 alkyl or benzyl;R.sub.7 is halogen, R.sub.5 or R.sub.6 ;n is independently an integer from 0 to 3;m is independently an integer from 1 to 3;s is independently 0 or 1; andy is independently an integer from 2 to 4;provided that n is not 0 when s is 1 and further provided that the compound of Formula (I) is not:[(S),(S)]-N,N'-(1,4-xylenediyl)bis[2-acetamido-6,7,8,8a-tetrahydropyrrolo[1 ,2-.alpha.]pyrazine-1,4(2H, 3H)-dione];[(R),(R)]-2,2'-(1,2-xylenediyl)bis[6,7,8,8a-tetrahydropyrrolo[1,2-.alpha.]p yrazine-1,4(2H,3H-dione]; or[(S),(S)]-2,2'-(1,3-xylenediyl)bis[6,7,8,8a-tetrahydropyrrolo[1,2-.alpha.]p yrazine-1,4(2H,3H-dione];or a pharmaceutically acceptable salt thereof.