Patent ID: 9164102
Filing Date: 2015-10-20
Classification: C40B,G01N

Abstract:
1. A method comprising a. contacting a TRPM4b channel with a candidate agent; wherein said TRPM4b is expressed in a recombinant cell, b. measuring the monovalent cationic permeability of said TRPM4b channel after contacting with said candidate bioactive agent; and c. comparing said monovalent cationic permeability of said TRPM4b channel after contacting with said candidate bioactive agent with the monovalent cationic permeability of said TRPM4b channel in the absence of said candidate bioactive agent to determine whether said bioactive agent modulates the monvalent cationic permeability of said TRPM4b channel. wherein said TRPM4b has an amino acid sequence comprising SEQ. ID No: 2and is impermeable to Ca