Patent ID: 6306884
Filing Date: 2001-10-23
Classification: A61P,C07C,C07D

Abstract:
A compound of selected from the group consisting of the following formulae: ##STR13##whereinA is --N.dbd.;Z.sup.1 and Z.sup.2 are independently --N(R.sup.8)-- or --S--;R.sup.1 and R.sup.3 are independently hydrogen, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --C(O)N(W)CH.sub.2 C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, --N(R.sup.8)S(O).sub.2 R.sup.12, or --N(R.sup.8)C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9 ;R.sup.2 is hydrogen; halo; alkyl; haloalkoxy; --OR.sup.8 ; --C(O)OR.sup.8 ; --C(O)N(R.sup.8)R.sup.9 ; --N(R.sup.8)R.sup.9 ; --C(O)N(R.sup.8)(CH.sub.2).sub.m C(O)OR.sup.8 (where m is 0 to 3); --N(R.sup.8)(CH.sub.2).sub.n C(O)OR.sup.8 (where n is 1 to 3); --N((CH.sub.2).sub.n N(R.sup.8)R.sup.9)(CH.sub.2).sub.n C(O)OR.sup.8 (where each n is 1 to 3); --O(CH.sub.2).sub.n C(O)N(R.sup.8)R.sup.9 (where n is 1 to 3); --O(CH.sub.2).sub.p C(O)OR.sup.8 (where p is 1 to 6); --N(R.sup.8)(CH.sub.2).sub.n C(O)N(R.sup.8)(CH.sub.2).sub.n C(O)OR.sup.8 (where each n is independently 1 to 3); morpholin-4-yl; 3-tetrahydrofuranoxy;or R.sup.2 is aryloxy (optionally substituted by one or more substituents independently selected from the group consisting of --OR.sup.8, --C(O)N(R.sup.8)R.sup.9, halo, alkyl, carboxy, alkoxycarbonyl, haloalkoxy, haloalkoxycarbonyl, alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, (alkylamino)carbonylalkyl, (dialkylamino)carbonylalkyl, (arylamino)carbonylalkyl, (aralkylamino)carbonylalkyl, alkoxycarbonylalkenyl, carboxyalkenyl, aminocarbonylalkenyl, (alkylamino)carbonylalkenyl, (dialkylamino)carbonylalkenyl, (arylamino)carbonylalkenyl, (aralkylamino)carbonylalkenyl, (hydroxyalkoxy)carbonyl, (alkoxy)alkoxycarbonyl, (hydroxyalkoxy)alkoxycarbonyl, ((alkoxy)alkoxy)alkoxycarbonyl, tetrazolyl, morpholin-4-ylalkyl, and (1,2)-imidazolinyl (optionally substituted by alkyl));or R.sup.2 is piperazin-1-yl (optionally substituted by one or more substituents independently selected from the group consisting of alkyl, carboxy, --C(O)N(R.sup.8)R.sup.9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl);or R.sup.2 is 1-piperazinoyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, carboxy, --C(O)N(R.sup.8)R.sup.9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl);or R.sup.2 is piperidin-1-yl (optionally substituted by one or more substituents selected from the group consisting of carboxy, --C(O)N(R.sup.8)R.sup.9, carboxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl);or R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkylcarbonyl, carboxy, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, and tetrazolylalkyl);or R.sup.2 is piperidin-4-ylamino (wherein the amino is optionally substituted by alkyl and the piperidinyl group is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxycarbonyl, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonylalkyl and aralklyl);or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, amidino, 1-iminoethyl, carboxy, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl and alkoxycarbonylalkyl);R.sup.4 and R.sup.7 are independently hydrogen, halo, alkyl, nitro, --OR.sup.8, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)R.sup.9, --N(H)C(O)R.sup.8, or --N(H)S(O).sub.2 R.sup.12 ;R.sup.5 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.8, --C(NH)N(H)C(O)OR.sup.12, --C(NH)N(H)S(O).sub.2 R.sup.12, --C(NH)N(H)C(O)N(R.sup.8)R.sup.9, or --C(NH)N(H)C(O)R.sup.8 ;R.sup.6 is halo, alkyl, haloalkyl, haloalkoxy, nitro, amino, ureido, guanidino, --OR.sup.8, --C(NH)NH.sub.2, --C(NH)NHOH, --C(O)R.sup.10, --(CH.sub.2).sub.m C(O)N(R.sup.8)R.sup.9 (where m is 0 to 3), --CH(OH)C(O)N(R.sup.8)R.sup.9, --(CH.sub.2).sub.m N(R.sup.8)R.sup.9 (where m is 0 to 3), --(CH.sub.2).sub.m C(O)OR.sup.8 (where m is 0 to 3), --N(H)C(O)R.sup.8, (1,2)-tetrahydropyrimidinyl (optionally substituted by alkyl), (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);each R.sup.8 and R.sup.9 is independently hydrogen, alkyl, aryl, or aralkyl;R.sup.10 is hydrogen, alkyl, aryl, aralkyl, 1-pyrrolidinyl, 4-morpolinyl, 4-piperazinyl, 4-(N-methyl)piperazinyl, or piperidin-1-yl; andR.sup.12 is alkyl, aryl or aralkyl;or a pharmaceutically acceptable salt thereof.