Patent ID: 6946559
Filing Date: 2005-09-20
Classification: C07C,C07D,C07F

Abstract:
1. A process for exchanging a halogen atom present in a halogenated compound for an electrophilic group, which comprises: reacting (i) (1) a halogenated compound represented by the formula: wherein Y 1 is a divalent organic residue, Y 2 is a monovalent organic residue, or Y 1 and Y 2 , when taken together, represent a trivalent organic residue, X 2 is a halogen atom, and n 1 is 0 or 1, or (2) a halogenated compound represented by the formula: wherein A is an optionally substituted aromatic ring, n 2 is 0 or 1 and X 3 is a halogen atom, with (ii) an exchange reagent which comprises a mixture of (A) (1) a magnesium compound represented by the formula: wherein R 1 is a halogen atom or an optionally substituted hydrocarbon residue, and X 1 is a halogen atom or (2) a member selected from the group consisting of diethylmagnesium, dipropylmagnesium, diisopropylmagnesium, di-n-butylmagnesium, di-sec-butylmagnesium, di-tert-butylmagnesium, diphenylmagnesium, divinylmagnesium, diallylmagnesium, di(2-furyl)magnesium, di(3-furyl)magnesium, di(2-thienyl)magnesium, di(3-thienyl)magnesium and dibenzylmagnesium and (B) an organolithium compound represented by the formula: wherein R 2 is an optionally substituted hydrocarbon residue, or a reaction product from (A) and (B), reacting the resultant product with (iii) a compound having an electrophilic group, and optionally treating the resultant product with an acid.