Patent ID: 6046360
Filing Date: 2000-04-04
Classification: C07B,C07C

Abstract:
A process for preparing 4-substituted cyclohexylamines of cis configuration by reductive amination of cyclohexanones in the presence of hydrogen and, if appropriate, an organic solvent or a mixture of organic solvents, which process comprisesa) reacting, in a first step, a cyclohexanone of the formula I with a benzylic amine VI in the presence of a catalyst comprising at least one metal from the group consisting of nickel and the platinum metals, to give N-benzylic cyclohexylamines of the formula VII, andb) reacting, in a second step, these N-benzylic cyclohexylamines, if appropriate after the organic solvent has been changed or removed, in the presence of a catalyst comprising at least one metal from the group consisting of the platinum metals, to give the 4-substituted cis-cyclohexylamines of the formula II ##STR4## where R, Ph and X are as defined below: R is an optionally substituted aliphatic or aromatic radical or a silyl radical which is substituted by alkyl, alkoxy and/or phenyl radicals;Ph is phenyl;X is hydrogen or methyl.