Patent ID: 6027720
Filing Date: 2000-02-22
Classification: A61K,C07K,C12N,Y10S

Abstract:
A modified polypeptide having human granulocyte colony stimulating factor (hG-CSF) activity comprising a polypeptide having an amino acid sequence SEQ ID NO:1, the human mature granulocyte colony stimulating factor (hmG-CSF) polypeptide with at least one amino group thereof modified by a group of the formula ##STR28## wherein R.sub.1 is an alkyl or alkanoyl group;n is an optionally variable positive integer;X is O, NH or S; ##STR29## where R.sub.3 is OH, Cl, or O--(CH.sub.2 CH.sub.2 O).sub.n --R.sub.1, where R.sub.1 and n are as defined above, Y may not be present or represents Z-(CH.sub.2).sub.p CO, where Z is O, S or NH and p is an optionally variable positive integer;or R.sub.2 is (CO).sub.m --(CH.sub.2).sub.1 CO, where m is 0 or 1 and l is an optionally variable positive integer.