Patent ID: 8815273
Filing Date: 2014-08-26
Classification: A61L,Y10T

Abstract:
1. A method of forming an implantable or insertable medical device comprising: (a) forming a predecessor structure that comprises an assembly of microspheres disposed over an underlying substrate, the microspheres carrying a first therapeutic agent, the first therapeutic agent being loaded to the microspheres by conjugating the first therapeutic agent with a surface of the microspheres or by forming a coating layer containing the first therapeutic agent on the microspheres, (b) mixing with or conjugating to a biodegradable polymer a second therapeutic agent and using the mixed or conjugated biodegradable polymer and the second therapeutic agent to form a biodegradable, porous layer over said substrate using said microspheres as templates for pores of the porous layer, (c) removing portions of or all of the microspheres to form the porous layer, with the pores containing the first therapeutic agent, and (d) loading the pores of the porous layer with a third therapeutic agent.