Patent ID: 6340685
Filing Date: 2002-01-22
Classification: A61P,C07D

Abstract:
A compound of the formula: and the pharmaceutically acceptable salts thereof, wherein each of Z1 and Z2 is independently CR4 or N; where each R4 is independently selected from H and alkyl (1-6C); wherein said alkyl optionally includes one or more heteroatoms selected from O, S and N, and wherein said alkyl is optionally substituted by one or more substituents selected from halo, OR, SR, NR2, RCO, COOR, CONR2, OOCR, NROCR, CN, &boxH;O, a 5 or 6 membered saturated carbocyclic ring or heterocyclic ring containing 1-2 N, and a 6-membered aromatic ring optionally containing 1-2 N heteroatoms, wherein R in the foregoing optional substituents is H or alkyl (1-6C); R1 is â€ƒwherein X1 is CO, SO, CHOH or SO2; m is 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl; n is 0, 1 or 2; Z3 is N; X2 is CH or CH2; and Ar consists of one or two phenyl moieties directly coupled to X2, said one or two phenyl moieties being optionally substituted by a substituent selected from halo, nitro, alkyl (1-6C), alkenyl (1-6C), CN, CF3, RCO, COOR, CONR2, NR2, OR, SR, OOCR, NROCR, (wherein R in the foregoing is H or 1-6C alkyl), and phenyl, itself optionally substituted by the foregoing substituents; R2 is selected from H, and alkyl (1-6C); wherein said alkyl optionally includes one or more heteroatoms which are selected from O, S and N, and wherein said alkyl is optionally substituted by one or more substituents selected from halo, OR, SR, NR2, RCO, COOR, CONR2, OOCR, NROCR, (where R in the foregoing is H or 1-6C alkyl) CN &boxH;O, a 5 or 6 membered saturated carbocyclic ring or heterocyclic ring containing 1-2 N, and a 6-membered aromatic ring optionally containing 1-2 N heteroatoms; with the proviso that if Z1 and Z2 are both CH, R2 is other than H R3 is H, halo, NO2, alkyl (1-6C), alkenyl (1-6C), CN, OR, SR, NR2, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C).