Patent ID: 8623359
Filing Date: 2014-01-07
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an antibody antagonist to c-Met, or a cMet-binding fragment thereof, and an aminoheteroaryl compound, wherein: i) said antibody antagonist to c-Met comprises a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3 comprising, respectively, the amino acid sequences SEQ ID Nos. 1, 2 and 3; and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 comprising, respectively, the amino acid sequences SEQ ID Nos. 10, 11 and 12; and ii) said aminoheteroaryl compound is selected from the group consisting of compounds of formula I: and a pharmaceutically acceptable salt, hydrate or solvate thereof.