Patent ID: 9089569
Filing Date: 2015-07-28
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a subject suffering from or diagnosed with a disease and/or disorder mediated by FLAP activity, wherein the disease and/or disorder is selected from the group consisting of respiratory, cardiac and cardiovascular, autoimmune and allergic, carcinogenesis disease and/or disorder, comprising administering to the subject a therapeutically effective amount of at least one compound of Formula (I): wherein: X X X R  or X R  or R  or X X X X X R  or provided that the second eluting isomer of racemic cis-2-{1-(4-Cyanobenzyl)-6-[(5-methylpyridin-2-yl)methoxy]-1H-benzimidazol-2-yl}cyclohexanecarboxylic acid when purified by chiral SFC on (CHIRALCEL OJ-H 5 μm 250×20 mm) mobile phase (65% CO and solvates, hydrates, and pharmaceutically acceptable salts thereof.