Patent ID: 7265112
Filing Date: 2007-09-04
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating or lessening the severity of a disease, condition or disorder selected from fibrotic liver disease; hepatic isehemia-reperfusion injury; cerebral infarction; ischemic heart disease; renal disease; lung (pulmonary) fibrosis; liver fibrosis associated with hepatitis C, hepatitis B, delta hepatitis, chronic alcoholism, non-alcoholic steatohepatitis, stones in the bile duct, cholangiopathies selected from primary biliary cirrhosis and sclerosing cholangitis, autoimmune liver disease, and inherited metabolic disorders selected from Wilson's disease, hemochromatosis, and alpha-1 antitrypsin deficiency; damaged and/or ischemic organs, transplants or grafts; ischemia/reperfusion injury; stroke; cerebrovascular disease; myocardial ischemia; atherosclerosis; renal failure; renal fibrosis; idiopathic pulmonary fibrosis; wounds; ischemia/reperfusion injury in the brain, heart, liver, and kidney; myocardial perfusion as a consequence of chronic cardiac ischemia or myocardial infarction; vascular occlusion; liver fibrosis or cirrhosis; radiocontrast nephropathy; fibrosis secondary to renal obstruction; renal trauma and transplantation; renal failure secondary to chronic diabetes and/or hypertension; and/or diabetes mellitus; wherein the method comprises administering to a patient in need thereof: a compound and optionally a pharmaceutically acceptable carrier or diluent, where the compound has the structure: C(5)-positional isomer thereof or a prodrug, salt, hydrate, or ester thereof; wherein R R wherein R R R R