Patent ID: 9180093
Filing Date: 2015-11-10
Classification: A61K,C07B

Abstract:
1. A method of manufacturing a ready to inject bortezomib-containing pharmaceutical article comprising: formulating a liquid parenteral formulation that contains bortezomib such that the formulation exhibits equal or less than 10% degradation of the bortezomib at accelerated conditions after 3 months; wherein the liquid parenteral formulation is prepared as a single-phase liquid formulation that comprises a substantially non-aqueous solvent system suitable for injection and including at least 50 vol % propylene glycol, an aqueous buffer, and bortezomib, wherein the bortezomib is present in the formulation at a therapeutically effective concentration; and packaging the liquid parenteral formulation in an amount sufficient for at least two distinct uses into a container, wherein the container is configured to allow providing multiple independent dosages of the liquid formulation.