Patent ID: 7582744
Filing Date: 2009-09-01
Classification: A61K,A61P,C07F,C12N

Abstract:
1. An isolated oligonucleotide agent, comprising a nucleotide sequence consisting of from 12 to 23 nucleotides in length sufficiently complementary to a microRNA target sequence of about 12 to 23 nucleotides, wherein the nucleotide sequence of the oligonucleotide agent differs by no more than 1 or 2 nucleotides from full complementary to the microRNA target sequence and wherein said oligonucleotide agent has the structure (I) wherein Q is a 2′-O-methyl modified nucleoside; x, z One of A and B is S while the other is O; n=6-17; L is wherein: X is N(CO)R each of R R R R R one of E and F is S while the other is O.