Patent ID: 8632771
Filing Date: 2014-01-21
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. An isolated vitamin K-dependent polypeptide linked to a polyethylene glycol (PEG) polymer, wherein said polypeptide is wild-type factor VIIa, wherein said PEG polymer has a molecular weight of 10,000 to 40,000 Da and is covalently linked to said wild-type factor VIIa polypeptide such that said wild-type factor VIIa polypeptide is monosubstituted with said PEG polymer, wherein said wild-type factor VIIa polypeptide linked to PEG retains measurable coagulation activity to a level that is from 4% to 15% of the level of coagulation activity of wild-type factor VIIa that is not conjugated to a PEG polymer, and where said coagulation activity is measured using a thromboplastin assay.