Patent ID: 6716962
Filing Date: 2004-04-06
Classification: A61K,C07K

Abstract:
A method for purifying a lipopeptide antibiotic, said method comprising the steps of:contacting an aqueous solution comprising a lipopeptide antibiotic, a divalent cation, and a pH above the isoelectric point of the lipopeptide antibiotic with an organic solvent, thereby extracting the lipopeptide antibiotic into the organic solvent, wherein the lipopeptide antibiotic is selected from the group consisting of zaomycin, crystallomycin, amphomycin, aspartocin, glumamycin, daptomycin, antibiotic A1437, antibiotic A-21978C, antibiotic A-54145 and tsushimycin; and contacting the organic solvent extract of the lipopeptide antibiotic with acid.