Patent ID: 6716453
Filing Date: 2004-04-06
Classification: A61K

Abstract:
A process for increasing the percentage of active ingredient relative to non-active excipients in a compressible formulation, consisting essentially of the steps of:i) determining a formula of a compression formulation including one or more active ingredients and a first amount of one or more non-active hardening or binder excipients; ii) preparing a revised formulation based on said formula wherein said first amount of excipient is replaced with an abrupt pressure treated polysaccharide material in a second amount of about 1 to about 50 percent by weight of said first amount of excipient; iii) mixing said revised formulation to form a reduced volume mixture; and iv) compressing said reduced volume mixture to form a composition wherein at least about 90% by weight of the composition is said active ingredient.