Patent ID: 7566782
Filing Date: 2009-07-28
Classification: A61P,C07D,C07F

Abstract:
1. A process for producing rosuvastatin of structural formula I, comprising: a. condensing 1-cyano (2S)-2-[(tert-butyldimethylsilyl)oxy]-5-oxo-6-triphenylphosphanylidene hexanenitrile of structural formula II with 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)-5-pyrimidinecarbaldehyde of structural formula III to give a condensed product of structural formula IV b. deprotecting of the tert-butyldimethylsilyl group of the condensed product to afford a cyanoketo alcohol of structural formula V, c. reducing the cyanoketo alcohol to cyanodiol of structural formula VI, d. hydrolyzing the cyanodiol of structural formula VI.