Patent ID: 8735066
Filing Date: 2014-05-27
Classification: A01K,A61K,C07K,C12N,C12Q,G01N

Abstract:
1. A method for determining whether a cell in a sample from a patient has homozygous loss of a genetic locus encoding a protein consisting of the amino acid sequence of SEQ ID NO:2, the method comprising: (a) contacting said sample with a nucleic acid probe comprising at least 95 contiguous nucleotides of SEQ ID NO:20; (b) detecting whether said probe hybridizes to a nucleic acid molecule from said cell; and (c)(1) determining that said cell has homozygous loss of said genetic locus if there is substantially no hybridization between said probe and said nucleic acid, or (c)(2) determining that said cell does not have homozygous loss of said genetic locus if there is substantial hybridization between said probe and said nucleic acid.