Patent ID: 6383520
Filing Date: 2002-05-07
Classification: A61K,Y10S

Abstract:
A finely ground powder of N-(1-((2,4-diamino-6-pteridinyl)methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl)L-&agr;-aminoadipic acid having an average particle diameter of 5 to 25 &mgr;m and sustaining its crystallinity even after the grinding treatment, said finely ground powder having an endotherm of from 25 to 50 mJ/mg at an endothermic peak appearing at 185 to 195Â° C. in a differential scanning calorimetry, having, both before and after the grinding treatment, parts showing polarization when observed under a polarization microscope, and showing approximate equivalent endotherm reading compared to an unground bulk powder.