Patent ID: 8497103
Filing Date: 2013-07-30
Classification: C07K,C12P

Abstract:
1. An Aspergillus oryzae host cell comprising a heterologous polynucleotide encoding a C4-dicarboxylic acid transporter, wherein the heterologous polynucleotide: (a) encodes a C4-dicarboxylic acid transporter having at least 95% sequence identity to SEQ ID NO: 2, or the mature polypeptide sequence thereof; (b) hybridizes under high stringency conditions with the full-length complementary strand of SEQ ID NO: 1; or (c) has at least 95% sequence identity to SEQ ID NO: 1, or the mature polypeptide coding sequence thereof; wherein the host cell is capable of secreting at least 50% more C4-dicarboxylic acid compared to the host cell without the heterologous polynucleotide encoding the C4-dicarboxylic acid transporter when cultivated under the same conditions.