Patent ID: 8951563
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. A composition-of-matter comprising a cochleate and a polymer encapsulated in said cochleate, said cochleate being formed from a mixture of at least two phospholipids characterized by a melting temperature higher than 10° C., wherein at least one of said phospholipids is a zwitterionic phosphatidylethanolamine and at least another phospholipid is an anionic diphosphatidylglycerol, and wherein said polymer comprises from 2 to 12 combined units and an N-terminus unit attached to one-another via a peptide bond, each of said combined units consisting of an ω-amino-fatty acid moiety attached via a peptide bond to a lysine residue, each of said ω-amino-fatty acid moiety independently exhibits a hydrocarbon chain of 4-12 carbon atoms, and said N-terminus unit being selected from the group consisting of a lysine residue having a NC 10-16 fatty acid moiety attached thereto and a lysine residue having a C 10-16 fatty acid moiety attached thereto.