Patent ID: 7888329
Filing Date: 2011-02-15
Classification: A61P,C07H

Abstract:
1. A method for treating a pathological condition or symptom in a subject, wherein the activity of A 2A adenosine receptors is implicated and agonism of such activity is desired, comprising administering to the subject an effective amount of a compound of formula Ia or a pharmaceutically acceptable salt thereof: R each R independently is selected from the group consisting of H, C X is CH or N, provided that when X is CH then Z cannot be substituted with halogen, C Y is selected from the group consisting of O, NR Z is selected from the group consisting of 5-membered heteroaryl, 6-membered aryl, 6-membered heteroaryl, carbocyclic biaryl, and heterocyclic biaryl, wherein the point of attachment of Y to Z is a carbon atom on Z, wherein Z is substituted with 0-4 groups independently selected from the group consisting of F, Cl, Br, I, (C alternatively, Y and Z together form an indolyl, indolinyl, isoindolinyl, tetrahydroisoquinolinyl, or tetrahydroquinolinyl moiety wherein the point of attachment is via the ring nitrogen and wherein said indolyl, indolinyl, isoindolinyl, tetrahydroisoquinolinyl, or tetrahydroquinolinyl moiety, which is substituted with 0-4 groups independently selected from the group consisting of F, Cl, Br, I, C R R a is selected from 0, 1, and 2; m is selected from 1, 2, and 3; n is selected from 0, 1, and 2; each p independently is selected from 0, 1, and 2; and, q is selected from 0, 1, and 2.