Patent ID: 6607644
Filing Date: 2003-08-19
Classification: G01N

Abstract:
A microanalytical device for analyzing a fluid sample containing at least one analyte molecule, comprising:a substrate having a substantially planar substrate surface and a substrate microchannel formed in the substrate surface, wherein the substrate microchannel extends from an upstream terminus to a downstream terminus; a cover plate having a substantially planar cover plate surface and a cover plate microchannel formed on the cover plate surface, wherein the cover plate surface is arranged over the substrate surface; an inlet port in fluid communication with the substrate microchannel; a membrane interposed between the substrate and the cover plate and having at least one pore sized to allow passage of the analyte molecule from the substrate microchannel to the cover plate microchannel, wherein the at least one pore is located downstream from the inlet port; and an analyte altering moiety attached to an interior surface of the at least one pore, wherein the moiety is capable of chemically altering the analyte molecule.