Patent ID: 7994291
Filing Date: 2011-08-09
Classification: C07H,C12N,C12Q

Abstract:
1. An isolated antibody or fragment thereof that specifically binds the polypeptide comprising an amino acid sequence selected from the group consisting of: (a) the amino acid sequence set forth in SEQ ID NO: 4; (b) an amino acid sequence that is at least 95 percent identical to the amino acid sequence of SEQ ID NO: 4, wherein the polypeptide has the E3α ubiquitin ligase activity of the polypeptide set forth in SEQ ID NO: 4; and (c) the amino acid sequence set forth in SEQ ID NO: 4 with 1 to about 100 conservative amino acid substitution(s), wherein the polypeptide has the E3α ubiquitin ligase activity of the polypeptide set forth in SEQ ID NO: 4.