Patent ID: 7365209
Filing Date: 2008-04-29
Classification: A61P,C07D

Abstract:
1. A compound of formula: wherein Y is chosen from the group consisting of —O—, —S—, —SO L is a linker, said linker comprising from one to eight carbons and from zero to three nitrogens, sulfurs and oxygens, wherein at least two atoms are interposed between ring B and carbon β, said linker being straight chain, branched or cyclic, and, when cyclic, attached either at carbons a and b of ring B or, when R Q is NR E is hydroxy, or E is a biolabile residue such that E and the carboxyl to which it is attached together form an ester or amide cleavable in vivo to provide a compound in which E is hydroxy; R R R R R R taken together R R