Patent ID: 7018649
Filing Date: 2006-03-28
Classification: A61K

Abstract:
1. A method of effectively treating hypertension, angina, or both conditions in a human patient, comprising: administering felodipine transdermally to the human patient by applying a transdermal delivery system containing felodipine to the skin of a patient, and maintaining said transdermal delivery system in contact with the skin of said patient for at least 3 days, said transdermal delivery system maintaining an effective mean relative release rate to provide a therapeutic blood level of said felodipine within 36 hours from the initiation of the dosing interval, and thereafter maintaining a therapeutic blood level until the end of at least the three-day dosing interval. said transdermal delivery system having a mean relative release rate of from about 4.2 μg/cm from about 3.3 μg/cm from about 2.7 μtg/cm said transdermal delivery system providing a mean relative release rate of felodipine to provide a plasma level of felodipine of at least 0.1 ng/ml within about 6 hours after application of said transdermal delivery system onto the skin of said patient.