Patent ID: 7482010
Filing Date: 2009-01-27
Classification: A61K,C07K,Y10S

Abstract:
1. A hypoallergenic immunogenic composition, comprising (i) a Phl p 6 polypeptide molecule having a N-terminal truncation which makes the molecule exhibit reduced IgE binding capacity as compared with Phl p 6 and consisting of the amino acid sequence of SEQ ID NO: 18, SEQ ID NO: 19, or SEQ ID NO: 20; and (ii) a Phl p 6 polypeptide molecule having a C-terminal truncation which makes the molecule exhibit reduced IgE binding capacity as compared with Phl p 6 and consisting of the amino acid sequence of SEQ ID NO: 22, wherein the molecules of (i) and (ii) together span the complete sequence of the 110 amino acids of Phl p 6 consisting of the amino acids at positions 29-138 SEQ ID NO: 15.