Patent ID: 8911775
Filing Date: 2014-12-16
Classification: A61K,A61P,B82Y,C08F,C08G,C08L

Abstract:
1. A pH-sensitive block copolymer forming polyionic complex micelles, which is prepared by copolymerization of: (a) a polyethylene glycol compound; (b) a poly(amino acid) compound; and (c) a heterocyclic alkyl amine compound having the ability to induce the formation of ionic complexes, wherein the heterocyclic alkyl amine compound is selected from the group consisting of 1-(3-aminopropyl)imidazole, 1-(2-aminoethyl)pyrrolidine, 2-(2-aminoethyl)-1-methylpyrrolidine, N-(3-aminopropyl)-2-pipecoline, N-(N-methyl-N-benzene)-1-propylamine, N-(3-aminopropyl)-2-pyrrolidinone, 2-(2-pyridyl)ethylamine, 4-(2-aminoethyl)morpholine, 3-morpholinopropylamine, histidine, and mixtures thereof.