Patent ID: 6559174
Filing Date: 2003-05-06
Classification: A61K,C07D

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt thereof wherein:Ring A is an aryl or heteroaryl ring, wherein ring A is optionally substituted with one to four substituents independently selected from Rb; X and Y are independently selected from 1) halogen, 2) C1-3alkyl, 3) C1-3alkoxy; Z is 1) N, 2) N+â€”Oâˆ’; R1 is 1) hydrogen, 2) C1-10alkyl, 3) aryl-C1-10alkyl; R2 is 1) hydrogen or 2) C1-10alkyl, wherein alkyl is optionally substituted with one to four substituents selected from a group independently selected from Rc;R3 is 1) hydrogen; 2) OH; 3) OCH3; or 4) NH2; Ra is 1) â€”ORd, 2) â€”NRdS(O)mRe, 3) â€”NO2, 4) halogen 5) â€”S(O)pRd, 6) â€”SRd, 7) â€”S(O)2ORd, 8) â€”S(O)mNRdRe, 9) â€”NRdRe, 10) â€”O(CRfRg)nNRdRe, 11) â€”C(O)Rd, 12) â€”CO2Rd, 13) â€”CO2(CRfRg)nCONRdRe, 14) â€”OC(O)Rd, 15) â€”CN, 16) â€”C(O)NRdRe, 17) â€”NRdC(O)Re, 18) â€”OC(O)NRdRe, 19) â€”NRdC(O)ORe, 20) â€”NRdC(O)NRdRe, 21) â€”CRd(Nâ€”ORe), 22) CF3, 23) â€”OCF3, 24) C3-8cycloalkyl, or 25) heterocyclyl; wherein cycloalkyl and heterocyclyl are optionally substituted with one to four groups independently selected from Rc;Rb is 1) a group selected from Ra, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 5) Ar1, 6) C1-10alkyl-Ar1, wherein alkyl, alkenyl, alkynyl, and Ar1 are optionally substituted with one to four substituents selected from a group independently selected from Rc;Rc is 1) halogen, 2) amino, 3) carboxy, 4) C1-4alkyl, 5) C1-4alkoxy, 6) aryl, 7) aryl C1-4alkyl, 8) hydroxy, 9) cyano, 10) CF3, 11) OCF3 12) OC(O)C1-4alkyl, 13) OC(O)NRfRg, or 14) aryloxy; Rd and Re are independently selected from hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, Cy and Cy C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Cy are optionally substituted with one to four substituents independently selected from Re; or Rd and Rg together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N-Rh; Rf and Rg are independently selected from hydrogen, C1-10alkyl, Cy and Cy-C1-10alkyl; or Rf and Rg together with the carbon to which they are attached form a ring of 5 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen; Rh is selected from Rf and â€”C(O)Rf; Cy is selected from cycloalkyl, heterocyclyl, aryl, and heteroaryl; Ar1 is selected from phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl each optionally substituted with one or two groups independently selected from Rc; Ar2 is 1,4-phenylene or 2,5-pyridylene; p is 1 or 2; m is 0, 1 or 2; n is 0, 1 or 2.