Patent ID: 6046185
Filing Date: 2000-04-04
Classification: C07J,Y02P,Y10S

Abstract:
A compound of the formula ##STR126## or pharmaceutically acceptable salts or solvates thereof, in which: each of C1, C2, C4, C11, C12, and C15 is independently substituted with --R.sup.4 or --OR.sup.1 ;C3 is substituted with II and --OR.sup.1 ; --OR.sup.1 and --OR.sup.1 ; or .dbd.O;each of C5, C6, C7, C8, C9, C10, C13, C14, and C16 is independently substituted with --R.sup.1 ;the A, B, C and D rings may independently be fully saturated, partially saturated or fully unsaturated;R.sup.1 is H or a hydroxy protecting, group, where vicinal --OR.sup.1 groups may together form a cyclic structure which protects vicinal hydroxyl groups, and where geminal --OR.sup.1 groups may together form a cyclic structure which protects a carbonyl group, with the proviso that either or both of --OR.sup.1 at C6 and C7 represents a carbonyl or protected carbonyl group; andR.sup.3 and R.sup.4 at each occurrence is independently selected from H and non-heterocyclic C.sub.1-30 hydrocarbon groups that may optionally be substituted with at least one heteroatom selected from the group consisting of boron, halogen, nitrogen, oxygen, silicon and sulfur.