Patent ID: 6380211
Filing Date: 2002-04-30
Classification: A61P,C07D,C07F

Abstract:
A method of treating diabetes in an animal comprising administering to said animal an effective amount of a compound of formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein:R1, when present, is hydrogen or lower alkyl; R2 is lower alkyl, aryl, aralkyl, lower alkanoyl, or â€”(CH2)nâ€”(CHOH)y(CH2)mA, wherein n is 1-4, y is 0 or 1, m is 0-5, and A is cycloalkyl, cycloalkenyl, lower alkanoyl, aryl, aralkyl, â€”NH2, â€”NHâ€”(lower alkyl), Y represents the atoms necessary to form a fused 5- to 6-membered, substituted or unsubstituted, aromatic carbocyclic ring; Z is (ii) â€”R6C&boxH;CR3â€” where R6 and R3 are independently hydrogen, lower alkyl, aryl, aralkyl, chlorine, bromine or â€”NR7R8, where R7 and R8 are independently hydrogen or lower alkyl, or, R6 and R3, taken together, form a fused 5- to 6-membered, aromatic or nonaromatic, carbocyclic or heterocyclic ring.