Patent ID: 6555537
Filing Date: 2003-04-29
Classification: A61P,C07D

Abstract:
A method of treating an inflammatory disorder selected from the group consisting of multiple sclerosis and encephalomyelitis in a human, which method comprises administering to a human in need of such treatment a therapeutically effective amount of a compound of formula (Ia): wherein:R1a is a substituent selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, (hydroxy)aralkyl, haloalkylcarbonylaminoalkyl, alkoxyalkyl, monoalkylaminoalkyl, monoaralkylaminoalkyl, (alkoxycarbonylalkyl)ureidoalkyl, hydroxyalkylaminoalkyl, aryloxyalkylcarbonyloxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl; or R1a is two substituents, wherein one substituent is an alkyl radical and the other substituent is selected from the group consisting of alkyl, (hydroxy)aralkyl, hydroxyalkyl, alkylthioalkyl, aralkoxyalkyl, (hydroxy)alkylthioalkyl, alkylcarbonylalkyl, dialkylaminoalkyl, cycloalkylaminoalkyl, morpholin-4-ylalkyl, and piperazin-4-ylalkyl; R2 is fluoro in the 4-position; R3 is phenyl optionally substituted by one to three substituents selected from the group consisting of halo, alkoxy, alkylcarbonylamino, and piperazin-4-ylalkyl (wherein the piperazinyl radical is optionally substituted by phenylcarbonyl where the phenyl radical is optionally substituted by haloalkyl); R4 is â€”Oâ€”; R5 is methylene; and R6 is â€”C(O)â€”; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.