Patent ID: 6562857
Filing Date: 2003-05-13
Classification: A61K,A61P,C07D

Abstract:
A compound having the structure of formula 1: wherein:T is absent; R1 and R2 are each, independently, hydrogen, alkyl, or substituted alkyl; or R1 and R2 are taken together to form a ring selected from the group consisting of â€”CH2(CH2)nCH2â€”, â€”CH2CH2C(CH3)2CH2CH2â€”, â€”O(CH2)pCH2â€”, â€”O(CH2)qOâ€”, â€”CH2CH2OCH2CH2â€”, and â€”CH2CH2NR7CH2CH2â€”; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA; RA is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, or substituted alkoxy; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or CORB; RB is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl; wherein said alkyl groups have 1 to 6 carbon atoms; said alkenyl groups have 2 to 6 carbon atoms; and said alkynyl groups have 2 to 6 carbon atoms; and wherein said substituted alkyl, alkenyl, alkynyl, alkoxy, and aminoalkyl groups have one or more substituents selected from the group selected from the group consisting of halogen, CN, OH, NO2, amino, alkoxy, aryloxy, substituted alkyloxy, alkylcarbonyl, alkylcarboxy, alkylamino, and arylthio; or a pharmaceutically acceptable salt thereof.