Patent ID: 6264922
Filing Date: 2001-07-24
Classification: A61K,A61P,B82Y

Abstract:
A nebulized aerosol of a dispersion of liquid droplets, wherein:(a) the liquid droplets have a particle size of less than about ten microns in diameter;(b) the liquid droplets consist essentially of a liquid, a crystalline therapeutic agent, and at least one surface modifier; and(c) the aerosol is useful for delivery of the nanoparticles to the lungs of a mammal;wherein said nanoparticles consist essentially of:(i) crystalline particles of a therapeutic agent which is poorly soluble in said liquid, wherein the crystalline agent particles have an effective average particle size of less than about 1000 nm; and(ii) about 0.1 to 90% (w/w) of at least one surface modifier, based upon the combined weight of the surface modifier and the therapeutic agent, adsorbed on the surface of the crystalline therapeutic agent particles.