Patent ID: 8084059
Filing Date: 2011-12-27
Classification: A61K,A61P,Y10S

Abstract:
1. A dosage form having sustained-release or controlled-release properties for delivering 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol from the dosage form over an extended period of time in a therapeutically responsive dose to produce antidepressant therapy, the dosage form comprising: (a) a wall comprising at least in part a composition permeable to the passage of fluid, but not to 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol, which wall surrounds; (b) a compartment comprising a first layer and a second layer; (c) a drug composition in the first layer of the compartment comprising 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol and a hydroxypropylalkylcellulose wherein said alkyl is of 1 to 7 carbons or a hydroxyalkylcellulose wherein said alkyl is of 1 to 6 carbons; (d) a displacement composition in the second layer of the compartment comprising an osmotically active compound; and (e) an exit passageway in the dosage form for delivering the drug composition from the dosage form.