Patent ID: 7682631
Filing Date: 2010-03-23
Classification: A61K,B82Y

Abstract:
1. A process for agglomerating biologically active microorganisms comprising: contacting a first enteropathogenic microorganism with a first particle having an average diameter between about 30 nanometers and about 5 micrometers, the first particle comprising a polystyrene hydrophobic polymeric core and multiple polyethylene glycol hydrophilic polymeric linking agents bound to the polystyrene hydrophobic polymeric core, the polyethylene glycol hydrophilic linking agents having a degree of polymerization of between about 10 and about 200, the particle further comprising D-mannose bound to the hydrophilic linking agents, the D-mannose being bound to the hydrophilic linking agent at a distance from the hydrophobic core, the D-mannose comprising a first binding site for a first adhesin present on the surface of the enteropathogenic microorganism, wherein the enteropathic microorganism is binding the first adhesin of the first enteropathogenic microorganism to the first binding site of the D-mannose to form a particle/microorganism complex; and binding a second adhesin of a second enteropathogenic microorganism to a second binding site of the biofunctional material of the particle/microorganism complex, wherein the second enteropathogenic microorganism is