Patent ID: 9150909
Filing Date: 2015-10-06
Classification: C12Q,G01N

Abstract:
1. A method of improving accuracy and reproducibility of determining a level of integrity of a sample of ribonucleic acid (RNA) and/or deoxyribonucleic acid (DNA) molecules, the method comprising: receiving a first size profile of the sample of the RNA and/or DNA molecules, wherein a size profile provides a measure of a distribution of values of at least one dimension of the RNA and/or DNA molecules, in the sample, the at least one dimension including length and/or weight; comparing, with an electrophoresis system, the first size profile to a plurality of reference size profiles, wherein each reference size profile correlates to a different level of integrity; and based on a similarity of the first size profile to one or more of the reference size profiles, determining, with the electrophoresis system, the level of integrity of the sample of RNA and/or DNA molecules, wherein the plurality of reference size profiles is obtained by: at each of a plurality of different elapsed times relative to an initial time: