Patent ID: 6417172
Filing Date: 2002-07-09
Classification: A61K,A61P,C07H

Abstract:
A method of preventing endotoxemia associated with pulmonary exposure to endotoxin in a subject, said method comprising administering to said subject an antiendotoxin compound having the formula: where R1 is selected from the group consisting of â€ƒwhere each J, K, and Q, independently, is straight or branched C1 to C15 alkyl; L is O, NH, or CH2; M is O or NH; and G is NH, O, S, SO, or SO2; R2 is straight or branched C5 to C15 alkyl; R3 is selected from the group consisting of straight or branched C5 to C18 alkyl, â€ƒwhere E is NH, O, S, SO, or SO2; each A, B, and D, independently, is straight or branched C1 to C15 alkyl; R4 is selected from the group consisting of straight or branched C4 to C20 alkyl, and â€ƒwhere each U and V, independently, is straight or branched C2 to C15 alkyl, and W is hydrogen or straight or branched C1 to C5 alkyl; RA is R5 or R5â€”Oâ€”CH2â€”, R5 being selected from the group consisting of hydrogen, Jâ€², â€”Jâ€²â€”OH, â€”Jâ€²â€”Oâ€”Kâ€², â€”Jâ€²â€”Oâ€”Kâ€²â€”OH, and â€”Jâ€²â€”Oâ€”PO(OH)2, where each Jâ€² and Kâ€², independently, is straight or branched C1 to C5 alkyl; R6 is selected from the group consisting of hydroxy, halogen, C1 to C5 alkoxy, and C1 to C5 acyloxy; A1 and A2, independently, are selected from the group consisting of â€ƒwhere Z is straight or branched C1 to C10 alkyl; or pharmaceutically acceptable salts thereof.