Patent ID: 7427493
Filing Date: 2008-09-23
Classification: C12N

Abstract:
1. An isolated, purified, or recombinant nucleic acid comprising a polyketide modifying gene, wherein said gene encodes a MegL and/or a MegM polyketide modifying enzyme, and wherein said nucleic acid optionally comprises a polyketide modifying gene encoding a polyketide modifying enzyme selected from the group consisting of MegR, MegCIV, MegCV, MegBVI, and MegBIII, wherein MegR has the sequence encoded by nucleotides 52-942 of SEQ ID NO:1, MegCIV has the sequence encoded by nucleotides 3893-5098 of SEQ ID NO:1, MegCV has the sequence encoded by nucleotides 2386-3855 of SEQ ID NO:1, MegBVI has the sequence encoded by nucleotides 5095-6558 of SEQ ID NO:1, MegBIII has the sequence encoded by nucleotides 12316-13548 of SEQ ID NO:1, MegL has the sequence encoded by nucleotides 14908-15972 of SEQ ID NO:1, and MegM has the sequence encoded by nucleotides 13928-14911 of SEQ ID NO:1, and wherein the nucleic acid does not comprise the S. erythraea Meg CII gene (nucleotides 6962-8038 of SEQ ID NO:1).