Patent ID: 6326160
Filing Date: 2001-12-04
Classification: A61B,Y10S,Y10T

Abstract:
One or more microprocessors for use in an analyte monitoring system, said one or more microprocessors programmed to:(i) control a measurement cycle comprising(a) operating a sampling device for extracting a series of samples at selected time intervals from a biological system, wherein each sample comprises the analyte, and(b) operating a sensing device for sensing the analyte in each extracted sample to obtain a raw signal from each sample that is related to the analyte amount or concentration in the biological system, thus providing a series of raw signals at selected time intervals, said sensing device comprising a sensor,(ii) correlate the raw signals with measurement values indicative of the amount or concentration of analyte present in the biological system, and(iii) predict a measurement value using a Mixtures of Experts algorithm, where the individual experts have a linear form ##EQU23##wherein (An) is an analyte of interest, n is the number of experts, An.sub.i is the analyte predicted by Expert i; and w.sub.i is a weighting value, and the individual experts An.sub.i are further defined by the expression shown as Equation (2) ##EQU24##wherein, An.sub.i is the analyte predicted by Expert i; P.sub.j is one of m parameters, m is typically less than 100; .alpha..sub.ij are coefficients; and z.sub.i is a constant; and further where the weighting value, w.sub.i, is defined by the formula shown as Equation (3) ##EQU25##where e refers to the exponential function and the d.sub.k are a parameter set analogous to Equation 2 that is used to determine the weights w.sub.i, the d.sub.k are given by Equation 4 ##EQU26##where .alpha..sub.jk is a coefficient, P.sub.j is one of m parameters, and where .omega..sub.k is a constant.