Patent ID: 8853407
Filing Date: 2014-10-07
Classification: C07D

Abstract:
1. A process for the manufacture of 4-aryl 1,4-diacyl 1,4-dihydropyridine of the general structure I (STR#1) comprising the steps of a. Mixing 4-arylpyridine, acid anhydride and indium metal in a reactor b. Raising the reaction temperature to about 50°-110° C. c. Maintaining the reaction time ranging from 1 hr to 24 hrs d. Quenching the reaction with water and e. Isolating the final product 4-aryl 1,4-diacyl 1,4-dihydropyridine by crystallization or chromatography Wherein the Ar The R functional group is selected from methyl, ethyl, propyl, butyl, t-butyl, phenyl and benzyl.