Patent ID: 6319928
Filing Date: 2001-11-20
Classification: A61P,C07D

Abstract:
A compound of the formula (II): ##STR10##whereinR.sub.2 is O or S;R.sub.6a represents H a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, halogen, haloalkyl, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CH.dbd.NOH, CH.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1 -.sub.4), optionally substituted with halogen, C.sub.1 -C.sub.3 alkyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 cycloalkoxy; a five to seven membered heterocyclyl ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms; and heterocyclylalkyl (C.sub.1 -C.sub.4) wherein said heterocyclyl moiety is a five to seven membered ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms;R.sub.3 represents a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, halogen, haloalkyl, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CH.dbd.NOH, CH.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1 -.sub.4), optionally substituted with halogen, C.sub.1 -C.sub.3 alkyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 cycloalkoxy; a five to seven membered heterocyclyl ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms; and heterocyclylalkyl (C.sub.1 -C.sub.4) wherein said heterocyclyl moiety is a five to seven membered ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms;R.sub.8 represents a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3 or C.sub.7-8 monocyclic cycloalkyl which is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, halogen, haloalkyl, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CH.dbd.NOH, CH.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1 -.sub.4), optionally substituted with halogen, C.sub.1 -C.sub.3 alkyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 cycloalkoxy; a five to seven membered heterocyclyl ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms; and heterocyclylalkyl (C.sub.1 -C.sub.4) wherein said heterocyclyl moiety is a five to seven membered ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms;R.sub.6b represents a H or R.sub.6a, or together R.sub.6b, N, and R.sub.6a make a 3 to 8 member ring containing at least one carbon atom, from one to three nitrogen atoms, from zero to two oxygen atoms, from zero to two sulfur atoms, said ring optionally substituted with alkoxy, CO.sub.2 H, CONH.sub.2, .dbd.NOH, .dbd.NOCONH.sub.2, .dbd.O; andpharmaceutically acceptable salts thereof.