Patent ID: 6384025
Filing Date: 2002-05-07
Classification: A61K,A61P,A61Q,C07C,C07J

Abstract:
A retinol derivative of formula (I): wherein R is selected from the group consisting of:(a) an unsubstituted cyclic, saturated or unsaturated, C1-C18 hydrocarbon-based radical, an unsubstituted linear or branched, saturated or unsaturated, C12-C18 hydrocarbon-based radical, or a substituted linear, cyclic or branched, saturated or unsaturated C1-C18 hydrocarbon-based radical, which is substituted with one or more groups â€”OH, â€”ORâ€², â€”NHCOR, â€”SH, â€”SRâ€², â€”COOH, â€”CONHRâ€², â€”COORâ€², â€”CN or â€”CF3, in which Râ€² is a C1-C4 alkyl radical; with a halogen atom; or with: (i) one or more saturated or unsaturated, substituted or unsubstituted C3-C7 aliphatic rings, or (ii) one or more substituted or unsubstituted aromatic rings, or (iii) one or more saturated or unsaturated, substituted or unsubstituted C3-C7 heterocycles, or (iv) one or more amino acid or peptide residues, (b) a radical of cyclopentanephenanthrene structure, which is at least partially hydrogenated and/or substituted, (c) an aryl radical optionally substituted with one or more groups â€”OH, â€”NH2, â€”SH, â€”COOH, â€”CONHRâ€², â€”NHCOR, â€”COORâ€², â€”ORâ€², â€”SRâ€², â€”CN or â€”CF3, in which Râ€² is a C1-C4 alkyl; with a halogen atom; or with: (i) one or more saturated or unsaturated, substituted or unsubstituted C3-C7 aliphatic rings, or (ii) one or more substituted or unsubstituted aromatic rings, or (iii) one or more saturated or unsaturated, substituted or unsubstituted C3-C7 heterocycles, wherein substituted chroman groups are excluded;(d) a group derived from ceramide, sphingosine or sphinganine; (e) an amino acid or peptide residue bearing a free hydroxyl group; and (f) a carbohydrate residue.