Patent ID: 6720433
Filing Date: 2004-04-13
Classification: A61K,A61P,C07K

Abstract:
A compound represented by the formula (1): whereinR1 is an optionally substituted aromatic ring; R2 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms, an amino group or a hydroxy group; R3 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms, an optionally substituted amino group or a hydroxy group; R4 is a hydrogen atom, a methyl group or an ethyl group; R5 is an optionally substituted straight-chained or branched alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-7 carbon atoms or an optionally substituted phenyl group; R6 is a hydrogen atom, a methyl group or an ethyl group; R7 is a hydrogen atom, an optionally substituted straight-chained or branched alkyl group having 1-3 carbon atoms or â€”COâ€”N(R9)R10; R8 is an optionally substituted 5-membered heterocyclic ring or an optionally substituted bicyclic ring system comprising a 5-membered heterocyclic ring; R11 is a hydroxy group or a halogen atom; R12, when R11 is a hydroxy group, represents a substituted straight-chained or branched alkyl group having 1-6 carbon atoms, a substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, a substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a straight-chained or branched acyl group having 2-6 carbon atoms, a straight-chained or branched alkylsulfonyl group having 1-5 carbon atoms or an amino group mono- or di-substituted with a straight-chained or branched alkyl group having 1-5 carbon atoms, and R12, when R11 is a halogen atom, represents an optionally substituted straight-chained or branched alkyl group having 1-6 carbon atoms, an optionally substituted straight-chained or branched alkenyl group having 2-6 carbon atoms, an optionally substituted straight-chained or branched alkynyl group having 2-6 carbon atoms, a straight-chained or branched acyl group having 2-6 carbon atoms, a straight-chained or branched alkylsulfonyl group having 1-5 carbon atoms or an amino group mono- or di-substituted with a straight-chained or branched alkyl group having 1-5 carbon atoms; X is a carbonyl group or a methylene group; and Y is a carbonyl group or a methylene group; or a hydrate or pharmaceutically acceptable salt thereof.