Patent ID: 8268548
Filing Date: 2012-09-18
Classification: A61P,C12Q,G01N

Abstract:
1. A method of identifying a candidate p53 pathway modulating agent, said method comprising the steps of: (a) providing an assay system comprising a mitogen activated protein kinase kinase kinase (MAP3K) nucleic acid, wherein the MAP3K nucleic acid comprises SEQ ID NO:1, SEQ ID NO:4, or SEQ ID NO:5; (b) contacting the assay system with a test agent; (c) measuring the expression of the MAP3K nucleic acid in the presence or absence of the test agent of step (b); and (d) identifying the test agent as a candidate p53 pathway modulating agent by determining a change in the expression of MAP3K nucleic acid in the presence of said test agent compared to the absence of said test agent.