Patent ID: 8349361
Filing Date: 2013-01-08
Classification: A61K

Abstract:
1. A particulate composition for rapid disintegrating tablets in oral cavity comprising (a) a combination of mannitol and xylitol in an amount of 40 to 90 parts by weight of the composition; (b) an inorganic excipient in an amount of 1 to 30 parts by weight of the composition; and (c) a disintegrating agent in an amount of 5 to 40 parts by weight of the composition, wherein the total amount of (a), (b) and (c) is 100 parts by weight of the composition, wherein mannitol and xylitol form complex particles and the inorganic excipient and the disintegrating agent are homogeneously dispersed in the complex particles, wherein the composition is obtained by spraying an aqueous solution or dispersion comprising (a), (b) and (c) in a solvent with a spray nozzle and drying the resultant sprayed solution or dispersion to remove the solvent.