Patent ID: 8568991
Filing Date: 2013-10-29
Classification: G01N

Abstract:
1. A method of probing multiple targets in a biological sample comprising: (a) providing a biological sample containing multiple targets; (b) binding at least one probe to the biological sample and wherein said probe comprises a binder and at least one of a optical signal generator or a fluorescent signal generator and wherein the binder is capable of binding specifically to one or more targets in the biological sample; (c) observing a signal from the at least one probe bound in step (b); (d) contacting the biological sample comprising the bound probe of step (b) with an electron transfer reagent, wherein the electron transfer reagent is a borate salt represented by the following structural formula: wherein: each R (e) irradiating the biological sample of step (d); (f) binding at least one probe to one or more targets present in the sample of step (e); and (g) observing a signal from the probe bound in step (f).