Patent ID: 8445635
Filing Date: 2013-05-21
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for treating cancer in a reproductive tissue of a subject, the method comprising administering to said subject in need thereof, a therapeutically effective amount of a H2 relaxin antagonist comprising (i) an A-chain and (ii) a B-chain or a homolog or analog of the B-chain, wherein the B-chain comprises an amino acid modification at position 13, 17, 20 or a combination thereof of the amino acid sequence DSWMEEVIKLCGRELVRAQIAICGMSTWS, wherein the first residue (D) is at position 1 and the last residue (S) is at position 29, and wherein the B-chain homolog or analog comprises an amino acid modification at a position equivalent to position 13, 17, 20 or a combination thereof.