Patent ID: 8138182
Filing Date: 2012-03-20
Classification: A61K,A61P,C07C,C07D,C07F,Y02A

Abstract:
1. A compound of formula (I) [wherein R is (1) hydrogen, (2) CycA, (3) C (wherein CycA is a C R (5) C R AA (wherein R (a) —NR R (wherein R R R R and AA (wherein CycB is a 5-12 membered mono- or bi-cyclic heteroring and the other symbols have the same meaning as hereinbefore), AA (wherein R (a) —NR R (wherein R R R R when AA CycC is a 3-17 membered mono- or bi-cyclic heteroring, CycD is a C AA (wherein CycE is a 4-18 membered mono- or bi-cyclic heteroring, CycF is a 5-8 membered monocyclic heteroring, and the other symbols have the same meaning as hereinbefore), R (i) —NR R R R R R R is a group selected from the following (1), (2) or (3); [wherein R (wherein R R R R CycP is a C R (wherein CycH is a C R (wherein CycJ is a 5-10 membered mono- or bi-cyclic heteroring and R [wherein R R R R (wherein CycK is a 5-10 membered mono- or bi-cyclic heteroring and R R (wherein CycL is a 5-10 membered mono- or bi-cyclic heteroring and R [wherein n is an integer of 1 or 2, and the other symbols have the same meaning as hereinbefore, and R (wherein CycM is a 5-10 membered mono- or bi-cyclic heteroring and the other symbols have the same meaning as hereinbefore) or R (wherein CycN is a 5-10 membered mono- or bi-cyclic heteroring and the other symbols have the same meaning as hereinbefore)], CycA's, CycB, CycC, CycD, CycE, CycF, CycH, CycJ, CycK, CycL, CycM, CycN and CycP may be each independently substituted with 1-5 of R R (i) halogen, (ii) —NR (wherein R R CycG's are each independently, a C R R when a saturated carbon atom exists in CycH, CycJ, CycK, CycL, CycM or CycN, the saturated carbon atom may form a spiro bond with CycQ (wherein CycQ is a C3-10 saturated or partially unsaturated mono-cyclic carboring or a 5-8 membered saturated or partially unsaturated monocyclic heteroring comprising 1 of —NR