Patent ID: 6605726
Filing Date: 2003-08-12
Classification: C07D,Y02P

Abstract:
A process for production of a compound of formula I: whereinR is methyl, and R6 is a straight-chain or branched-chain alkyl group with up to 6 carbon atoms, a cycloalkylalkyl group with up to 10 carbon atoms, a phenyl group, 1- or 2-naphthyl group, a heteroaryl group, benzyl, or a methylheteroaryl group, said process comprising:a) reacting a compound of formula 3 â€ƒwherein PG3 is a hydroxy protective group, and FG3 is a phenylsulfonyl group, with a compound of formula 4 â€ƒwherein FG4 is an iodine atom or another leaving group, and PG4 is a hydroxy protective group, to form a compound of formula 34-I b) reacting the compound of formula 34-I with a compound of formula 2 â€ƒwherein PG21 and PG22, independently of one another, are in each case a hydroxy protective group, to form a compound of formula 234 c) reacting the compound of formula 234 over the following stages d) converting the resultant compound by epoxidation to form a compound according to formula I.