Patent ID: 6207446
Filing Date: 2001-03-27
Classification: C07B,C07K,C12N,C40B,G01N

Abstract:
A microchip comprising an array of immobilized single-stranded nucleic acids, said nucleic acids being hybridized to RNA-protein fusions, wherein each of said RNA-protein fusions comprises an RNA covalently bonded at the RNA 3' end to a protein through a peptide acceptor selected from the group consisting of puromycin, tRNA-puromycin conjugate, phenylalanyl-adenosine, tyrosyl adenosine, alanyl adenosine, phenylalanyl 3' deoxy 3' amino adenosine, alanyl 3' deoxy 3' amino adenosine, and tyrosyl 3' deoxy 3' amino adenosine, and wherein said protein is encoded by said covalently bonded RNA.