Patent ID: 7217706
Filing Date: 2007-05-15
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method for the treatment of dysuria that comprises: administering to a subject in need of treatment for dysuria an amount of a compound effective to treat dysuria, wherein said compound is a β wherein: (a) the compound of formula (IV) is: wherein: R R R where R R R R R A is a bond, —(CH with the proviso that when A is a bond or —(CH (b) the compound of formula (V) is: wherein A is pyridinyl; n is 0 to 5; R R R R Z is (1) phenyl, (2) naphthyl, (3) or a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, (4) a benzene ring fused to a cycloalkyl ring, (5) a benzene ring fused to a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, (6) a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen fused to a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, or (7) a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from the group consisting for oxygen, sulfur and nitrogen fused to a C R X is (1) —CH m is 0 or 1; R R r is 0 to 3; and R R n is 0 to 5; (c) the compound of formula (VI) is: wherein X is hydrogen, halogen, trifluoromethyl or lower alkyl, and R is hydrogen; lower alkyl which may have a suitable substituent selected from the group consisting of cyclo(C (d) the compound of formula (VII) is: wherein R R R R R R X is an oxygen atom or a bond; Y is an alkylene group of up to 6 carbon atoms or a bond; and Z is an alkylene, alkenylene or alkynylene group of up to 10 carbon atoms; and (e) the compound of formula (VIII) is: wherein R is hydrogen or methyl, R R R R R R X is N, O, S or methylene; provided that when X is N, O or S, then R provided that when X is methylene, then both R