Patent ID: 7951401
Filing Date: 2011-05-31
Classification: A61K

Abstract:
1. A process for the preparation of a composite containing a drug dispersed in a particulate organic carrier, comprising: a) mixing a drug and a particulate organic carrier selected from the group consisting of water-soluble complexing agents, water-insoluble cross-linked polymers, and mixtures thereof; and b) applying an oscillating electromagnetic field to the mixture, wherein the oscillating electromagnetic field is microwave irradiation modulated to increase the temperature of the mixture to a temperature greater than the melting temperature of the drug and maintained at the temperature greater than the melting temperature of the drug for at least 5 minutes to provide a composite containing the drug, wherein the drug is dispersed inside of the organic carrier particles as well as on the external surface of the particles, wherein the drug is present in the composite in amorphous form in a quantity greater than or equal to 50% by weight based on the total amount of the drug.