Patent ID: 6150407
Filing Date: 2000-11-21
Classification: A61K,A61P

Abstract:
A method of inhibiting angiogenesis in a tissue or organ in which same is intended, said method comprising contacting said tissue or organ with an anti-angiogenic amount of a compound having the formula: ##STR9## or a pharmaceutically acceptable salt thereof; wherein:R.sup.1 is C.sub.1 -C.sub.6 -alkyl;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently selected from group consisting of hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, aryl, hydroxyl, C.sub.1 -C.sub.6 -alkoxy, halogen, NO.sub.2 and NH.sub.2 ;R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, aryl, hydroxyl, C.sub.1 -C.sub.6 -alkoxy, halogen, NO.sub.2 and NH.sub.2 ;Y is O or S; andX is selected from the group consisting of oxygen, sulfur, --CH.sub.2 -- and carboxy or is nil.