Patent ID: 9066901
Filing Date: 2015-06-30
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for treating angiogenesis or obesity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an isolated angiotensin-like factor, said angiotensin-like factor being selected from the group consisting of: (a) a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4 or 3 amino acids, or a peptidomimetic thereof, of general formula I: N-X (b) a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4 or 3 amino acids, or a peptidomimetic thereof, of general formula I: N-X (c) a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4 or 3 amino acids, or a peptidomimetic thereof, said polypeptide comprising (i) a tripeptide having an amino acid sequence that is selected from: Lys-Asp-Tyr, Leu-Asp-Tyr, Asp-Tyr-Ile, Tyr-Ile-Arg, Ile-Arg-Asn, and Arg-Asn-Cys, and (ii) at least one of an amino terminus and a carboxy terminus, each of said amino terminus and said carboxy terminus consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17 amino acids that are independently selected from natural and non-natural amino acids; (d) the polypeptide or peptidomimetic of (a) which comprises the amino acid sequence Nle-Tyr-Leu-Ψ-His-Pro-Phe as set forth in SEQ ID NO:43, wherein Ψ consists of a reduced peptide bond of formula II: —CH (e) the polypeptide or peptidomimetic of (b) which comprises at least one amino acid sequence selected from SEQ ID NOS: 9, 25, 33, 41, 42, 45-50, 52-80 and 81.