Patent ID: 9012393
Filing Date: 2015-04-21
Classification: A61K,A61L,A61P

Abstract:
1. A method for modifying the release of a platelet derived growth factor (PDGF) protein, said protein selected from the group consisting of PDGF-AB and PDGF-BB, from a fibrin sealant, wherein the fibrin sealant is produced by admixture of a fibrinogen complex (FC) component, a thrombin component and a PDGF component, the method comprising, a) determining the amount of PDGF released from a first fibrin sealant having a known initial amount of PDGF and a known final concentration of FC and b) modifying the known final concentration of FC used in the first fibrin sealant of step (a) to produce a second fibrin sealant, wherein the second sealant has the same initial amount of PDGF as the first sealant in step (a); wherein increasing the concentration of the FC in the second sealant compared to the known final concentration of FC in the first sealant decreases the rate of PDGF release from the second sealant as compared to the release of PDGF from the first sealant of step (a); or wherein decreasing the concentration of FC in the second sealant compared to the known final concentration of FC in the first sealant increases the rate of PDGF release from the second sealant as compared to the release of PDGF from the first sealant of step (a).