Patent ID: 6677362
Filing Date: 2004-01-13
Classification: A61K

Abstract:
A process for the preparation of a poorly water soluble drug in solid dispersion comprising:a) blending a poorly water soluble drug with a solvent-free carrier, said solvent-free carrier selected from the group consisting of polyvinylpyrrolidone, high molecular weight polyethylene glycols, urea, citric acid, vinyl acetate copolymer, acrylic polymers, succinic acid, sugars and mixtures thereof; b) dissolving a surfactant selected from the group consisting of Tween, Span, Pluronics, polyoxyethylene sorbitol esters, monodiglycerides, polyoxyethylene acid polyoxyethylene alcohol and mixtures thereof, and a plasticizer/solubilizer selected from the group consisting of low molecular weight polyethylene glycol, propylene glycol, glycerin, triacetin, triethyl citrate, sugar alcohols and mixtures thereof, in water; c) spraying the surfactant-plasticizer/solubilizer solution onto the drug/carrier mixture in a fluid bed granulator; and d) milling the extrudate to a powdery mass of the solid drug dispersion.