Patent ID: 6211167
Filing Date: 2001-04-03
Classification: A61P,C07F

Abstract:
A compound having the formula: ##STR21##or a pharmaceutically acceptable salt thereof, whereinR.sup.1 is a member selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl and (C.sub.1 -C.sub.6)heteroalkyl;R.sup.2 and R.sup.3 are each independently selected from the group consisting of hydrogen, halogen, (C.sub.1 -C.sub.8)alkyl, (C.sub.1 -C.sub.8)heteroalkyl, --OR.sup.11 and --NR.sup.11 R.sup.12, wherein R.sup.11 and R.sup.12 are each independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.8)alkyl and (C.sub.1 -C.sub.8)heteroalkyl; orR.sup.2 and R.sup.3, when attached to adjacent carbon atoms, can be linked together to form a fused 5-, 6- or 7-membered ring;R.sup.4 and R.sup.5 are each independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.8)alkyl, (C.sub.1 -C.sub.8)heteroalkyl, aryl, heteroaryl, aryl(C.sub.1 -C.sub.4)alkyl, aryl(C.sub.1 -C.sub.4)heteroalkyl, heteroaryl(C.sub.1 -C.sub.4)alkyl and heteroaryl(C.sub.1 -C.sub.4)heteroalkyl, and are optionally linked together to form a 5-, 6- or 7-membered ring; orR.sup.4 represents a single bond to the phenyl ring bearing the phosphoryl group andR.sup.5 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.8)alkyl, (C.sub.1 -C.sub.8)heteroalkyl, aryl, heteroaryl, aryl(C.sub.1 -C.sub.4)alkyl, aryl(C.sub.1 -C.sub.4)heteroalkyl, heteroaryl(C.sub.1 -C.sub.4)alkyl and heteroaryl(C.sub.1 -C.sub.4)heteroalkyl; andAr is a substituted aryl group selected from the group consisting of: ##STR22##whereinX.sup.1 and X.sup.2 are each independently selected from the group consisting of F, Cl and Br.