Patent ID: 6277835
Filing Date: 2001-08-21
Classification: A61K,A61P

Abstract:
A method of treating a mammal having a solid tumor, said mammal in need of such treatment, comprising(a) administering to said mammal a synergistically effective amount of a compound having the formula ##STR28##n is 0 or 1; andY.sup.1 and Y.sup.2 are independently either H; nitro; halogen; hydrocarbyl (1-14C) including cyclic and unsaturated hydrocarbyl, optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, hydroxy, epoxy, alkoxy (1-4C), alkylthio (1-4C), primary amino (NH.sub.2), alkyl (1-4C) secondary amino, dialkyl (1-4C) tertiary amino, dialkyl (1-4C) tertiary amino where the two alkyls are linked together to produce a morpholino, pyrrolidino or piperidino, acyloxy (1-4C), acylamido (1-4C) and thio analogs thereof, acetylaminoalkyl (1-4C), carboxy, alkoxycarbonyl (1-4C), carbamyl, alkylcarbamyl (1-4C), alkylsulfonyl (1-4C) or alkylphosphonyl (1-4C), wherein the hydrocarbyl can optionally be interrupted by a single ether (--O--) linkage; or wherein Y.sup.1 and Y.sup.2 are independently either morpholino, pyrrolidino, piperidino, NH.sub.2, NHR', NR'R'O(CO)R', NH(CO)R', O(SO)R', or O(POR')R' in which R' is a hydrocarbyl (1-4C) which may be substituted with OH, NH.sub.2, alkyl (1-4C) secondary amino, dialkyl (1-4C) tertiary amino, morpholino, pyrrolidino, piperidino, alkoxy (1-4C), or halogen substituents, or pharmacologically acceptable salt of said compound; and(b) administering to said mammal, from about one half hour to about twenty-four hours after administering said compound, an effective amount of a chemotherapy agent to which said tumor is susceptible.