Patent ID: 7189883
Filing Date: 2007-03-13
Classification: C07B,C07C,C07F

Abstract:
1. A process for subjecting an olefin to an asymmetric reaction selected from the group consisting of hydroformylation, hydrocyanation, hydrocarboxylation and hydroesterification, which is carried out in the presence of, as catalyst, a transition metal complex of a bis(diazaphospholane) ligand according to formula (1), or the opposite enantiomer thereof, wherein (a) Bridge is a linking group selected from the group consisting of substituted and unsubstituted alkyl, substituted and unsubstituted alkenyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclyl, and substituted and unsubstituted ferrocenyl groups; (b) W, at each occurrence, is independently selected from the group consisting of substituted and unsubstituted aryl and heteroaryl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocyclyl, and substituted and unsubstituted alkyl; (c) T, at each occurrence, is independently selected from the group consisting of —C(O)OR 3 , —C(O)NR 4 R 5 , —C(O)N(R 4 )OR 5 , OR 3 , NR 4 R 5 , substituted and unsubstituted oxazole, substituted and unsubstituted oxazoline, substituted and unsubstituted oxazolidine, and substituted and unsubstituted alkyl; (d) R 1 and R 2 are independently selected from the group consisting of H, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, and substituted and unsubstituted aryl; or R 1 and R 2 may join together to form a substituted or unsubstituted aryl, a substituted or unsubstituted cycloalkyl, or a substituted or unsubstituted cycloalkenyl; (e) R 3 , R 4 and R 5 are each independently selected from the group consisting of —H, substituted and unsubstituted alkyl, substituted and unsubstituted aryl, substituted and unsubstituted aralkyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted heterocyclylalkyl; or R 4 and R 5 may join together to form a non-aromatic heterocyclyl; and (f) the dashed line, at each occurrence, represents an optional additional bond, such that a single or double carbon-carbon bond exists between C(R 1 ) and C(R 2 )