Patent ID: 6066671
Filing Date: 2000-05-23
Classification: A61K,A61P,Y10S

Abstract:
A method for treating GLC1A glaucoma which comprises topically administering to the eye a pharmaceutically effective amount of a compound of the structure: ##STR2## R=H, C.sub.1-4 (un)branched alkyl, CF.sub.3, SR.sup.4 Y=OR', NR""R'R'=H (except when Y=OR'), C.sub.1-10 (un)branched alkyl, (un)substituted (substitution as defined by X below), (un)substituted heterocycle (substitution as defined by X below),--(CH.sub.2).sub.n Z(CH.sub.2).sub.n' An=2-6n'=1-6Z=nothing, O, C.dbd.O, OC(.dbd.O), C(.dbd.O)O, C(.dbd.O)NR.sup.3, NR.sup.3 C(.dbd.O),S(O).sub.n 2, CHOR.sup.3, NR.sup.3n.sup.2 =0-2R.sup.3 =H, C.sub.1-6 (un)branched alkyl, (un)substituted aryl (substitution as defined by X below), (un)substituted heterocycle (substitution as defined by X below)A=H, OH, optionally (un)substituted aryl (substitution as defined by X below),(un)substituted heterocycle (substitution as defined by X below), --(CH.sub.2).sub.n OR.sup.3R""=H, OH, OR'X and X' independently=H, F, Cl, Br, I, OR', CN, OH, S(O).sub.n 2R.sup.4, CF.sub.3, R.sup.4, NO.sub.2R.sup.4 =C.sub.1-6 (un)branched alkylm=0-3m'=0-5W=O, H.