Patent ID: 7589126
Filing Date: 2009-09-15
Classification: A61K,A61P,C07C

Abstract:
1. A method for the treatment of a disease selected from the group consisting of cerebral infarction, cerebral thrombosis, cerebral embolism, transient cerebral ischemic attack (TIA), subarachnoid hemorrhage-induced cerebral vasospasm, myocardial infarction, unstable angina, atrial fibrillary thrombosis, pulmonary thrombosis, pulmonary embolism, Buerger's disease, peripheral arterial obstruction, deep venous thrombosis, disseminated intravascular coagulation syndrome, diabetic thrombotic complications, thrombus formation after artificial blood vessel operation or after artificial valve replacement, restenosis and reocclusion after coronary intervention of percutaneous transluminal coronary angioplasty (PTCA) or percutaneous transluminal coronary recanalization (PTCR) surgery and thrombus formation at the time of extracorporeal circulation, which comprises administering to a patient in need thereof an effective amount of a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 represents a hydrogen atom or a lower alkyl group which may have a substituent selected from the following group (A); (A) —COOR T represents an oxygen atom, a sulfur atom or a sulfonyl group; or TR R (B) an oxo group, a lower alkyl group, a halo(lower alkyl) group, —Y—R R (C) a lower alkyl group, an amino group or —COOR Q represents a hydrogen atom or a lower alkyl group which may have a substituent selected from the following group (D); (D) —OR Z represents a hydrogen atom, a hydroxy group or —COOR wherein R (viii) —OR or a pharmaceutically acceptable salt thereof.