Patent ID: 7742877
Filing Date: 2010-06-22
Classification: B01J,C12Q,C40B,G01N

Abstract:
1. A method of identifying a peptide with a desired activity having an indicia that satisfies a test requirement, the method comprising the steps of: identifying a predetermined set of peptides; parameterizing the predetermined set of peptides by: performing a space-filling design of the parameterized peptides to identify first test peptides; constructing a first test peptide library comprising a plurality of first test peptides identified using the space-filling design, wherein the length of said first test peptides comprises about four amino acids to about twenty amino acids, and wherein said first test peptides are a subset of said predetermined set of peptides; determining an activity, having an indicia, of said plurality of first test peptides; measuring the indicia of said activity for said plurality of first test peptides; deriving a quantitative relationship between said indicia of said activity, said first parameter, and said second parameter; calculating an estimated indicia for each remaining peptide from said predetermined set of peptides using said quantitative relationship; setting a test requirement, based on a desired activity, having a test indicia range; selecting a second test peptide library comprising at least one second test peptide, wherein each second test peptide has an estimated indicia that satisfies said test requirement, and wherein said second test peptides are not in said first test peptide library; measuring the indicia of each second test peptide; and identifying at least one second test peptide having a measured indicia that satisfies said test requirement.