Patent ID: 7621887
Filing Date: 2009-11-24
Classification: A61M

Abstract:
1. A method of loading a chamber of an automatic injection device with a medicament, the method comprising: inserting a first seal structure into the chamber at a user selected location within the chamber to divide the chamber into a front compartment and a rear compartment, the chamber having an open front end forming an open end of the front compartment and an open rear end forming an open end of the rear compartment, the chamber having no interior structures, the first seal structure initially sealing the front compartment from the rear compartment and having a moveable sealing plug operative to move within the first seal structure to open a flow path through the first seal structure around the outermost periphery of the sealing plug; filling the rear compartment of the chamber with a wet medicament portion through the rear end of the chamber, the wet medicament portion contacting interior side walls of the chamber; sealing the rear end of the chamber with a second seal structure movable toward the front compartment to force the wet medicament portion into the front compartment to mix with a dry medicament portion as the second seal structure moves toward the front compartment; filling the front compartment of the chamber with the dry medicament portion through the front end of the chamber; placing a tapered insert in the front end of the chamber, the tapered insert having a constant radially-inward taper extending from the rearward end of the insert to the front end of the insert, the constant radially-inward taper forming a tapered flow pathway through the insert, the insert having a rearward opening that forms a common boundary with the chamber, the rearward opening having a diameter that equals an inside diameter of the chamber where the rearward opening forms the common boundary; and sealing the front end of the chamber.