Patent ID: 6365626
Filing Date: 2002-04-02
Classification: A61K

Abstract:
A method for treating a disease that relates to improper platelet aggregation comprising administering to a patient a therapeutically effective amount of a leflunomide analog of formula I: where:R1 is (C1-C3)alkyl, (C3-C6)cycloalkyl, phenyl, or NRaRb; R2 is hydroxy, (C1-C6)alkoxy, (C1-C6)alkanoyloxy amino (C2-C5)alkoxy; hydroxy (C2-C5)alkoxy amino (C2-C5)alkanoxy; or hydroxy (C2-C5) alkanoxy; R3 is cyano or (C1-C3)alkanoyl; R4 is hydrogen, (C1-C3)alkyl; hydroxy (C2-C5)alkyl; or amino (C2-C5)alkyl; R5 is phenyl substituted by â€”S(O)2Rc, or by halo and at least one other substituent; Ra and Rb are each independently hydrogen, or (C1-C3)alkyl; or Ra and Rb together with the nitrogen to which they are attached are pyrrolidino, piperidino, morpholino, or thiomorpholino; wherein any phenyl of R1 and R5 is optionally substituted with one or more substituents independently selected from halo, nitro, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, (C1-C3)alkoxy, (C1-C3)alkyl, (C1-C3)alkanoyl, â€”S(O)2Rc, or NRaRb; wherein Rc is (C1-C3)alkyl, or phenyl or a pharmaceutically acceptable salt thereof.