Patent ID: 6086915
Filing Date: 2000-07-11
Classification: A61K,A61P

Abstract:
A process for the preparation of a composition comprising the steps of:a. beating one or more solubilizing emulsifiers selected from the group consisting of vitamin E succinate polyethylene glycol 1000, polyvinylpyrrolidone, polyoxyethylene stearate, sodium cholate, deoxycholate and taurocholate;b. adding to the product of step (a) one or more solvents and one or more surfactant phospholipids selected from the group consisting of phosphatidyl choline, dioleoyl phosphatidyl choline, phosphatidylglycerol, dioleoylphosphatidylglycerol, dimyristoylphosphatidylcholine, dipalitoylphosphatidyicholine, phosphatidylethanolamine, phosphatidylserine and sphingomyelin to produce a solution;c. dissolving in the solution of step (b) one or more hydrophobic phytochemicals selected from the group consisting of diindolylmethane (3,3'-diindolylmethane), linear tri-indole([2-(indol-3-ylmethyl)-indol-3yl]indol-3-ylmethane), cyclic tri-indole (5,6,11,12,17,18-hex-hydrocyclononal [1,2-b:4,5-b':7,8-b]: triindole), and linear di-indole (1(3-hydroxymethyl)indolyl-3indolymethane, chrysin (5,7-dihydroxyflavone), tectochlrysin (5-hyroxy,7-methyletherflavone), nepetin (5,3',4'-trihydroxy-6-methoxyflayone), tangeretin (5,6,7,8,4'-pentamethoxyflavone), tricetin (5,7-dihydroxy-3',5'-trimethoxyflavone), tricin (5,7,4'trihydroxy-3',5'-dimethoxyflavone), amentoflavone, pinocembrin (5,7-dihydroxyflavanone), narigenin (5,7,4'trihydroxyflavanone), biochanin A, genistein, daidzein, propolis and bee pollen;d. adding to the solution of step (c) a solution containing one or more encapsulators selected from the group consisting of starch, gelatin, methylcellulose, hdroxypropyl methylcellulose, hydroxyethylcellulose, hvdroxypropylethylcellulose, pectin and gum arabic;e. mixing the solution produced in step (d) to produce a microdispersion with a particle size of 5 microns or less; andf. spray drying the resulting mixture to leave a solid hydrophobic phytochemical composition;wherein the one or more emulsifiers comprise about 10 to about 40 percent by weight, the one or more solvents comprise about 1 5 to 30 percent by weight, the one or more surfactant phospholipids comprise about 5 to about 20 percent by weight, the one or more phytochemicals comprise about 10 to 40 percent by weight, and the one or more encapsulators comprise about 20 to 40 percent by weight of the microdispersion of step (e).