Patent ID: 6762166
Filing Date: 2004-07-13
Classification: A61K,C07K

Abstract:
A pharmaceutical composition for ophthalmologic uses, comprising a complementary peptide having a sequence complementary to prolineglycine-proline (PGP) (SEQ ID NO:1), wherein said complementary peptide is selected from the group consisting of RTR (SEQ ID NO:2), RTRGG (SEQ ID NO:3), RTR dimer, RTR tetramer, RTR octamer, N-acetyl-RTR multimer, short-chain and long-chain fatty acid RTR multimer, RTR multimer using diaminopropionic acid for the core subunit, RTR multimer using diaminobutyric acid for the core subunit, RTR multimer containing a spacer having the formula NH2[CH2]nâ€”COOH[n=2[3-aininopropionic acid];3;4;5;6; or 7[8-aminocaprylic acid]], said spacer replacing diglycine spacer, cysteine RTR multimer having a bicyclic structure, and XTR multimer with N-terminal modifications and core subunit modifications, wherein said complementary peptides have dextrorotatory amino acids substituting for the natural levorotatoxy, and wherein X may be any amino acid.