Patent ID: 6858410
Filing Date: 2005-02-22
Classification: A61P,C07K,C12N,C12P

Abstract:
1. A process for the production of an antifusogenic peptide by producing a fusion peptide of a length of from 14 amino acids up to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of 10 to 50 amino acids and a second peptide of a length of 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said infusion bodies and; (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of 10 to 50 amino acids resulting from cleavage of said fusion peptide.