Patent ID: 8722706
Filing Date: 2014-05-13
Classification: A61K,A61P,C07D

Abstract:
1. A composition comprising: a bis-quaternary pyridinium-2-aldoxime salt comprising the formula: wherein R1 is independently a methyl or ethyl group wherein said salt is in particle form at a diameter of 1.0 micron to 100 microns wherein said salt indicates: a) a plurality of distinguishing x-ray diffraction peaks at 2 Theta angles of 10-30 degrees as compared to non-distinguishing peaks at 2 Theta angles greater than 30 degrees, wherein said distinguishing x-ray diffraction peaks have relative intensity counts between 500-1500 at 2 Theta angles of 10-30 degrees and non-distinguishing x-ray diffraction peaks have relative intensity counts of less than 500 at 2 Theta angles of greater than 30 degrees and no peaks are present with relative intensity accounts of more than 250 at 2 Theta angles between 30-60 degrees and wherein said salt has a particulate structure comprising cubic rectangular geometry, or (b) a plurality of distinguishing x-ray diffraction peaks at 2 Theta angles of 10-30 degrees as compared to non-distinguishing peaks at 2 Theta angles greater than 30 degrees, wherein said distinguishing x-ray diffraction peaks have relative intensity counts between 1000-4500 at 2 Theta angles of 10-30 degrees and non-distinguishing x-ray diffraction peaks have relative intensity counts of less than 500 at 2 Theta angles of greater than 30 degrees and no peaks are present with relative intensity accounts of more than 500 at 2 Theta angles between 35-60 degrees and wherein said salt has a particulate structure comprising a hexagonal structure; and a liquid with which said salt is combined wherein the solubility of said particle in said liquid is less than or equal to 10% by weight, a two-phase (solid-liquid) system is provided, and said liquid is a fluorinated hydrocarbon.