Patent ID: 8389765
Filing Date: 2013-03-05
Classification: C07C

Abstract:
1. A process for the manufacture of iodixanol by performing a purification process of a crude product containing about 75-90 weight % iodixanol, 3-10 weight % iohexol, 3-7 weight % 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (Compound A) and minor amounts of other impurities in an aqueous solution comprising: an initial crystallization step comprising adjusting the water content of the aqueous solution and adding an initial amount of ethanol in an amount of 1 to 6 ml ethanol per ml of water, and a heating step comprising addition of a further amount of ethanol to a total amount of from 2 to 6 ml ethanol per g crude product.