Patent ID: 6958147
Filing Date: 2005-10-25
Classification: A61K,A61L,C07H,C07K,C12N

Abstract:
1. A method of treating a mammalian subject to inhibit restenosis of a blood vessel, comprising the step of: administering to a mammalian subject in need of treatment to inhibit restenosis of a blood vessel a composition comprising a replication-deficient adenovirus comprising a polynucleotide, wherein said composition is administered locally at the site in need of treatment to inhibit restenosis, wherein said polynucleotide comprises a nucleotide sequence that encodes a vascular endothelial growth factor C (VEGF-C) polypeptide operatively linked to a promoter to promote expression of the VEGF-C polypeptide in cells of the blood vessel, wherein the VEGF-C polypeptide comprises: wherein expression of said VEGF-C polypeptide in said blood vessel cells inhibits restenosis of said blood vessel.