Patent ID: 6919338
Filing Date: 2005-07-19
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) or a salt, ester, or amide thereof; wherein X is O or NH; R wherein any one of R 60 , R 61 , and R 62 is a substituent group and * indicates the point of attachment to the group X in formula (I), and the other two are each independently hydrogen or a C 1-3 alkyl R 1) hydrogen or C 2) C 3) C 4) C 5) R 6) C 7) C 8) C 9) R 10) C 11) C 12) C 13) C 14) C 15) C 16) C 17) C a group of sub-formula (II) a group of formula (VI) any one of R p and q are independently 0 or 1; and R T is C═O, SO V is independently R R R wherein J is aryl, heteroaryl or heterocyclyl and K is a bond, oxy, imino, N-(C any aryl, heteroaryl or heterocyclyl group in a R any aryl, heteroaryl or heterocyclyl group in a R wherein A 1 is halo, hydroxy, C 1-6 alkoxy, cyano, amino, N—C 1-6 alkylamino, N,N-(C 1-6 alkyl) 2 amino, carboxy, C 1-6 alkoxycarbonyl, carbamoyl, N—C 1-6 alkylcarbamoyl or N,N-(C 1-6 alkyl) 2 carbamoyl, p is 1 to 6, and B 1 is a bond, oxy, imino, N-(C 1-6 alkyl)imino or —NHC(O)—, with the proviso that p is 2 or more unless B any aryl, heteroaryl or heterocyclyl group in a R wherein D 1 is aryl, heteroaryl or heterocyclyl and E 1 is a bond, C 1-6 alkylene, oxyC 1-6 alkylene, oxy, imino, N-(C 1-6 alkyl)imino, iminoC 1-4 alkylene, N—C 1-4 alkyl)-iminoC 1-6 alkylene, C 1-6 alkylene-oxyC 1-6 alkylene, C 1-6 alkylene-iminoC 1-6 alkylene, C 1-6 alkylene-N-(C 1-6 alkyl)-iminoC 1-6 alkylene, —NHC(O)—, —NHSO 2 —, —SO 2 NH— or —NHC(O)—C 1-6 alkylene-, and any aryl, heteroaryl or heterocyclyl group in a substituent on D 1 may be optionally substituted with one or more groups selected from hydroxy, halo, C 1-6 alkyl, C 1-6 alkoxy, carboxy, C 1-6 alkoxycarbonyl, carbamoyl, N—C 1-6 alkylcarbamoyl, N-(C 1-6 alkyl) 2 carbamoyl, C 2-6 alkanoyl, amino, N—C 1-6 alkylamino and N,N-(C 1-6 alkyl) 2 amino, and any C and any of the R functional group is a reactive substituent selected from nitro, cyano, halo, oxo, ═CR