Patent ID: 6077934
Filing Date: 2000-06-20
Classification: A61K,C07K,Y10S

Abstract:
A substantially pure contryphan peptide of the generic formula:Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEO ID NO:1),whereinXaa.sub.1 is any amino acid or des-Xaa.sub.1,Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val,Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu,Xaa.sub.4 is any amino acid, andXaa.sub.5 is Trp or Tyr,with the proviso that the peptide does not have the formula Gly-Cys-Xaa.sub.2 -D-Trp-Glu-Pro-Trp-Cys or Cys-Xaa.sub.2 -D-Trp-Glu-Pro-Trp-Cys.