Patent ID: 8734429
Filing Date: 2014-05-27
Classification: A61K,A61M

Abstract:
1. A swallowable device for delivering a therapeutic agent preparation into an intestinal wall of a patient's intestinal tract, the swallowable device comprising: a swallowable capsule sized to pass through the intestinal tract, the capsule having a capsule wall, a least a portion of which degrades upon exposure to a selected pH in an intestine while protecting the capsule wall from degradation in a stomach of the patient; at least one expandable member assembly disposed within the capsule comprising a first compartment in at least a partially non-expanded state and a second compartment in at least a partially non-expanded state, the first and second compartments being fluidically separated by a degradable valve which degrades upon exposure to fluid in the intestinal tract; a liquid contained in one of the compartments; a reactant contained in the other compartment, wherein when the valve degrades, the liquid and the reactant mix to produce a gas which expands at least the second compartment; a delivery mechanism coupled to the second compartment, the delivery mechanism comprising at least one piston-cylinder assembly; and at least one tissue penetrating member comprising: wherein upon expansion of the second compartment, the at least one tissue penetrating member is advanced into the intestinal wall by the delivery mechanism where it is retained in the intestinal wall so as to deliver the therapeutic agent into the intestine.