Patent ID: 9012225
Filing Date: 2015-04-21
Classification: A61K,A61P,C07J,C12N

Abstract:
1. A lipophilic polynucleotide conjugate, comprising: a) a polynucleotide; and b) a lipophilic moiety selected from cholesterol, cholestene, cholestane, cholestadiene, bile acid, cholic acid, deoxycholic acid, or dehydrocholic acid, wherein the lipophilic moiety is spaced from the polynucleotide and any polar groups or exchangeable protons by a C4 to C10 hydrocarbon linker that is conjugated to the lipophilic moiety through an ether or thioether linkage, wherein the hydrocarbon linker separates any polar groups or exchangeable protons from the lipophilic moiety by at least 6 atoms, and wherein the hydrocarbon linker is conjugated to the polynucleotide through the polynucleotide 3′ position.