Patent ID: 6399587
Filing Date: 2002-06-04
Classification: A61K,A61P,C12N

Abstract:
A method for in vivo transferring a gene of interest into a host cell or organism comprisingintroducing into said host cell or organism in vivo an adenoviral vector derived from the genome of an adenovirus at least by deleting all or part of the E1 region, wherein said adenoviral vector contains a cassette for expressing a gene of interest; wherein said gene of interest is placed under the control of transcriptional and translational control elements required for expressing it in a host cell or organism; wherein said elements comprise at least one splicing sequence, which is located after the transcriptional initiation site or a promoter and before a poly A site; wherein said splicing sequence is derived from a &bgr;-globin gene or a sequence which is homologous with, or identical to, the sequence depicted in SEQ ID NO: 1 or SEQ ID NO:2.