Patent ID: 6359152
Filing Date: 2002-03-19
Classification: C07C,Y02P

Abstract:
A compound having the formula: where R is represented by the structure: where the stereochemical center at carbon 20 may have the R or S configuration, and where Z is selected from Y, â€”OY, â€”CH2OY, â€”Câ‰¡CY and â€”CH&boxH;CHY, where the double bond may have the cis or trans geometry, and where Y is selected from hydrogen, methyl, â€”COR5 and a radical of the structure: where m and n, independently, represent the integers from 0 to 5, where R1 is selected from hydrogen, deuterium, hydroxy, protected hydroxy, fluoro, trifluoromethyl, and C1-5-alkyl, which may be straight chain or branched and, optionally, bear a hydroxy or protected-hydroxy substituent, and where each of R3 and R4 is methyl, and where R2, is selected from deuterium, deuteroalkyl, hydrogen, fluoro, trifluoromethyl and C1-5 alkyl, which may be straight-chain or branched, and optionally, bear a hydroxy or protected-hydroxy substituent, and where R1 and R2, taken together, represent an oxo group, or an alkylidene group, &boxH;CR2R3, or the group â€”(CH2)pâ€”, where p is an integer from 2 to 5, and where R5 represents hydrogen, hydroxy, protected hydroxy, or C1-5 alkyl and wherein any of the CH-groups at positions 20, 22, or 23 in the side chain may be replaced by a nitrogen atom, or where any of the groups â€”CH(CH3)â€”, â€”CH(R3)â€”, or â€”CH(R2)â€” at positions 20, 22, and 23, respectively, may be replaced by an oxygen or sulfur atom, and X is an acyl group.