Patent ID: 6303660
Filing Date: 2001-10-16
Classification: A61K,A61P

Abstract:
Agent delivery system for delivery of anti-cancer agents to primary solid malignant tumors and metastases thereof in mammals, including man, comprising two components to be administered one after the other with a time interval between the administrations, whereinthe first component is,a) a primer composition for local delivery to primary solid malignant tumors or metastases thereof in mammals, including man, prior to administration of anti-cancer agents, comprising an interstitial pressure-lowering amount of a pharmaceutically acceptable agent which increases the intracellular levels of cyclic adenosine monophosphate (cAMP) in the normal connective tissue cells within solid malignant tumors selected from the group consisting of Prostaglandin E.sub.1, Prostaglandin E.sub.2, Prostaglandin I.sub.2, and esters of these prostaglandins, and a vehicle,for initial local delivery to a solid tumor area, andthe second component is,b) a therapeutically effective amount of an anti-cancer agent for subsequent local or systemic administration.