Patent ID: 7179809
Filing Date: 2007-02-20
Classification: A61P,C07D

Abstract:
1. Compounds of formula I wherein R a heteroarylmethyl or heteroarylethyl group, an arylcarbonylmethyl group, a heteroarylcarbonylmethyl group or an arylprop-2-enyl or heteroarylprop-2-enyl group, wherein the propenyl chain may be substituted by 1 to 4 fluorine atoms or a cyano, C X denotes a nitrogen atom, R a C an aryl or heteroaryl group, a C a trifluoromethyl, carboxy, C C a C a C R an arylmethyl or heteroarylmethyl group, a straight-chain or branched C or a straight-chain or branched C and R an amino group substituted by the groups R an amino group substituted by the groups R or an amino group substituted by the groups R while the above-mentioned groups R while by the aryl groups mentioned in the definition of the above groups are meant phenyl or naphthyl groups, which may be mono-, di- or trisubstituted independently of one another by R by the heteroaryl groups mentioned in the definition of the above-mentioned groups is meant a pyrrolyl, furanyl, thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, or is meant a pyrrolyl, furanyl, thienyl or pyridyl group, wherein one or two methyne groups are replaced by nitrogen atoms, or is meant an indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, wherein one to three methyne groups are replaced by nitrogen atoms, by the above-mentioned cycloalkyl groups as defined are meant both monocyclic and also polycyclic ring systems, while the polycyclic groups may be annelated, spiro-linked or bridged in structure, while, unless otherwise stated, the above-mentioned alkyl, alkenyl and alkynyl groups may be straight-chain or branched, while the carboxy groups mentioned in the definition of the above-mentioned groups may be replaced by a group which may be converted in vivo into a carboxy group or by a group which is negatively charged under physiological conditions, and the amino and imino groups mentionied in the definition of the above-mentioned groups may be substituted by a group which can be cleaved in vivo, the tautomers, enantiomers, diastereomers, the mixtures thereof, and the salts thereof.