Patent ID: 8476291
Filing Date: 2013-07-02
Classification: A61K,C07D

Abstract:
1. A method of administering an active pharmaceutical comprising: providing a drug substance consisting of an organic acid salt of an opioid as said active pharmaceutical wherein said drug substance does not have a wt % released at 30 minutes in 0.1 N hydrochloric acid in USP water comprising 20% USP ethanol which is higher than in 0.1 N hydrochloric acid in USP water without ethanol forming a drug product comprising said drug substance suitable for achieving a therapeutic dose of said drug substance in a predetermined time wherein when administered said therapeutic dose is not exceeded by ingestion of alcohol at biological pH; wherein said drug substance is selected from the group consisting of: amorphous oxycodone pamoate characterized by a method selected from the group consisting of: polymorphic oxycodone pamoate characterized by a method selected from the group consisting of: polymorphic oxycodone pamoate characterized by a method selected from the group consisting of: hydrocodone xinafoate characterized by a method selected from the group consisting of: amorphous hydromorphone pamoate characterized by a method selected from the group consisting of: