Patent ID: 6310076
Filing Date: 2001-10-30
Classification: C07D,C07F

Abstract:
A compound having the structure: ##STR282##wherein Q is OH, OR"", SH, SR'"", NH.sub.2, NHR'"", NR.sub.2 '"", NR""OH, NR"" OR'"", or a linear or branched chain alkyl group, or an arylalkyl group, or an alkenyl or alkynyl group, or an aryl group, where R"" is H, a linear or branched chain alkyl group, trialkylsilylalkyl, cyanoalkyl, or an aryl group, and R'"" is a linear or branched chain alkyl group, or an aryl group; wherein R.sup.0 and R.sup.1 are independently the same or different and are H, a linear or branched chain alkyl, an alkoxyalkyl, azidoalkyl, aminoalkoxyalkyl, azidoalkoxyalkyl, trihaloalkoxyalkyl, aminoalkyl, hydroxyalkyl, or an aryl group, or (CH.sub.2).sub.t W, where W is NH.sub.2, NHR', NR.sub.2 ', NHOH, N.sup.+ R.sub.3 'Z.sup.-, NHCOR', N.sub.3, NO.sub.2 or CH.sub.2 W.sup.0 (CH.sub.2).sub.v W.sup.1, or a linear or branched chain alkyl group, or an arylalkyl group, or an alkenyl or alkynyl group, or an aryl group, where R' is a linear or branched chain alkyl group, or an aryl group, where W.sup.0 is O, S or NH, where W.sup.1 is NH.sub.2, NHR', NR.sub.2 ', NHOH, N.sup.+ R.sub.3 'Z.sup.-, NHCOR', N.sub.3 or NO.sub.2, and where R' is a linear or branched chain alkyl group, or an aryl group, where Z.sup.- is a pharmaceutically acceptable counterion, and t is 1, 2, 3, 4, 5 or 6 and v is 2, 3, 4, 5 or 6; wherein R is H or a linear or branched chain alkyl or acyl group, or an aryl group; wherein R.sup.2, R.sup.9 and R.sup.10 are independently the same or different and are H or a linear or branched chain alkyl group; wherein R.sup.4 is a H or linear or branched chain alkyl, alkyloxymethyl, or alkoxyethyl group, or a hydroxymethyl or hydroxyethyl group, or a linear or branched chain alkenylalkyl group; wherein R.sup.7 and R.sup.8 are independently the same or different and are H, CN, CF.sub.3, OH, OR', OCOR', NH.sub.2, NHR', NR'.sub.2, NHCOR', CONH.sub.2, CONHR', CONR.sub.2 ', COOH, COOR', CHO, COR', COSH, COSR', COO(CH.sub.2).sub.q OH or COO(CH.sub.2).sub.q OR', or a benzyl group, a linear or branched chain alkyl or cycloalkyl group, or are a heteroaryl group comprising a pyridyl, indolyl, indolylalkyl, quinolinyl, isoquinolinyl, pyrryl, furyl or thiophene group, or an aryl group having the structure: ##STR283##wherein R.sup.9 and R.sup.10 are independently the same or different and are H, Cl, Br, I, F, OH, NO.sub.2, N.sub.3, OR.sup.iv, OCOR.sup.iv, OCOOR.sup.iv, OCONHR.sup.iv, NH.sub.2, NHR.sup.iv, NR.sup.iv.sub.2, NHCOR.sup.iv, NHCOOR.sup.iv or NRCONHR.sup.iv, where R' is a linear or branched chain alkyl group, and R.sup.iv is a linear or branched chain alkyl group, and q is 2, 3, 4 or 5; wherein R.sup.11 is H or a linear chain alkyl group; wherein R.sup.12 and R.sup.13 are independently the same or different and are H or a linear chain alkyl group; and wherein n is 2, 3 or 4.