Patent ID: 6399615
Filing Date: 2002-06-04
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein:a represents N or NOâˆ’; R1, R3 and R4 in Formula 1.1 are halo; R1, R2 and R3 in Formula 1.2 are halo; the dotted line (â€” â€” â€”) represents an optional bond; T represents whereinR5 represents H or (C1-C6)alkyl; b and c are independently 0 to 3; and Y represents R6 represents (C1-C6)alkyl or H; Z represents OR7, R7 or NR8R9; R7 represents H, (C1-C6)alkyl or (C1-C6)alkyl substituted by OR5, COR5, phenyl or heteroaryl; R8 and R9 independently represent H, OH, (C1-C6)alkyl or (C1-C6)alkyl substituted by OR5, COR5, phenyl, or heteroaryl, or R8 and R9 taken together with the nitrogen atom in NR8R9 form an unsubstituted or substituted five or six membered heterocyclic ring system containing carbon and one to four heteroatoms selected from N, O, S, SO or SO2, said heterocyclic substituents being (C1-C8)alkanoyl, (C1-C6)alkyl or (C1-C6)penthalo alkyl; or T represents wherein &boxH;Y&boxH; represents and when T represents and c is 0 or 1, and Y is cyclopropyl or cyclohexyl, then Z is also selected from NHO(C1-C6)alkyl or NH(C1-C6)alkylCO(C1-C6)alkoxy.