Patent ID: 6649768
Filing Date: 2003-11-18
Classification: C07D

Abstract:
A production method of an imidazole compound of the formula (1) whereinR1 is 3-pyridyl; and R2 is a hydrogen atom, an alkyl group optionally having substituent(s), an unsaturated alkyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), an arylalkenyl group optionally having substituent(s), an aryl-cyclic hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s) or a heterocyclic residue optionally having substituent(s), or a salt thereof, which comprises(a) converting, in dimethyl sulfoxide, a halogen compound of the formula (6) wherein R1 is as defined above, X is a chlorine atom or a bromine atom, m and n are each an integer of 1 or 2, and m+n is 3, or a salt thereof, to a glyoxal compound of the formula (2) wherein R1 is as defined above, or a salt thereof, and(b) reacting the glyoxal compound of the formula (2) or a salt thereof obtained in step (a) with ammonia and an aldehyde compound of the formula (3) wherein R2 is as defined above, or a salt thereof.