Patent ID: 7238716
Filing Date: 2007-07-03
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula wherein R (1) halogen atom, (2) nitro group, (3) an aliphatic hydrocarbon group having 1 to 15 carbon atoms, (4) an alicyclic hydrocarbon group having 3 to 12 carbon atoms, (5) an aromatic hydrocarbon group having 6 to 14 carbon atoms, (6) an acyl group which may have 1 to 3 substituents selected from the group consisting of a C (7) an amino group optionally mono- or di-substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, cycloalkyl group having 3 to 10 carbon atoms, cycloalkenyl group having 3 to 10 carbon atoms, aryl group having 6 to 14 carbon atoms or acyl group having 1 to 13 carbon atoms, (8) a hydroxy group which is optionally substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, aralkyl group having 7 to 13 carbon atoms, acyl group having 1 to 13 carbon atoms or aryl group having 6 to 14 carbon atoms, each of which group may have 1 or 2 substituents selected from the group consisting of a halogen atom and an alkoxy group having 1 to 3 carbon atoms, and (9) a thiol group which is optionally substituted by alkyl group having 1 to 10 carbon atoms, cycloalkyl group having 3 to 10 carbon atoms, aralkyl group having 7 to 13 carbon atoms, acyl group having 2 to 13 carbon atoms or aryl group having 6 to 14 carbon atoms, 1) a cycloalkyl group having 3 to 10 carbon atoms, 2) an aryl group having 6 to 14 carbon atoms, 3) an aralkyl group having 7 to 9 carbon atoms, 4) an amino group, 5) an amino group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms or acyl group having 2 to 8 carbon atoms, 6) an amidino group, 7) an acyl group having 2 to 8 carbon atoms, 8) a carbamoyl group, 9) a carbamoyl group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms, 10) a sulfamoyl group, 11) a sulfamoyl group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms, 12) a carboxyl group, 13) an alkoxycarbonyl group having 2 to 8 carbon atoms, 14) a hydroxy group, 15) a C 16) a C 17) a cycloalkyloxy group having 3 to 7 carbon atoms, 18) an aralkyloxy group having 7 to 9 carbon atoms, 19) an aryloxy group having 6 to 14 carbon atoms, 20) a thiol group, 21) a C 22) an aralkylthio group having 7 to 9 carbon atoms, 23) an arylthio group having 6 to 14 carbon atoms, 24) a sulfo group, 25) a cyano group, 26) an azide group, 27) a nitro group, 28) a nitroso group, and 29) a halogen atom, 1) a C 2) a C 3) a cycloalkyl group having 3 to 10 carbon atoms, 4) an aromatic hydrocarbon group having 6 to 14 carbon atoms, 5) an aralkyl group having 7 to 9 carbon atoms, 6) an amino group, (7) an amino group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms or acyl group having 2 to 8 carbon atoms, 8) an amidino group, 9) an acyl group having 2 to 8 carbon atoms, 10) a carbamoyl group, 11) a carbamoyl group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms, 12) a sulfamoyl group, 13) a sulfamoyl group mono- or di-substituted by alkyl group having 1 to 4 carbon atoms, 14) a carboxyl group, 15) an alkoxycarbonyl group having 2 to 8 carbon atoms, 16) a hydroxy group, 17) a C 18) a C 19) a cycloalkyloxy group having 3 to 7 carbon atoms, 20) an aralkyloxy group having 7 to 9 carbon atoms, 21) an aryloxy group having 6 to 14 carbon atoms, 22) a thiol group, 23) a C 24) an aralkylthio group having 7 to 9 carbon atoms, 25) an arylthio group having 6 to 14 carbon atoms, 26) a sulfo group, 27) a cyano group, 28) an azide group, 29) a nitro group, 30) a nitroso group, and 31) a halogen atom; X is a bond; Q is an alkylene group having 1 to 20 carbon atoms; Y is an oxygen atom; ring A is a benzene ring optionally further having 1 to 3 substituents selected from the group consisting of (1) an aliphatic hydrocarbon group having 1 to 15 carbon atoms which may have 1 to 3 substituents selected from the group consisting of (2) a hydroxy group which is optionally substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, aralkyl group having 7 to 13 carbon atoms, acyl group having 1 to 13 carbon atoms or aryl group having 6 to 14 carbon atoms, each of which group may have 1 to 2 substituents selected from the group consisting of a halogen atom and an alkoxy group having 1 to 3 carbon atoms, (3) halogen atom, (4) an acyl group which may have 1 to 3 substituents selected from the group consisting of a C (5) nitro group, and (6) an amino group optionally mono- or di-substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, cycloalkyl group having 3 to 10 carbon atoms, cycloalkenyl group having 3 to 10 carbon atoms, aryl group having 6 to 14 carbon atoms or acyl group having 1 to 13 carbon atoms; Z is —(CH ring B is a pyridine ring which optionally further has 1 to 3 substituents selected from the group consisting of (1) an aliphatic hydrocarbon group having 1 to 15 carbon atoms which may have 1 to 3 substituents selected from the group consisting of (2) an aromatic hydrocarbon group having 6 to 14 carbon atoms which may have 1 to 3 substituents selected from the group consisting of (3) a hydroxy group which is optionally substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, aralkyl group having 7 to 13 carbon atoms, acyl group having 1 to 13 carbon atoms or aryl group having 6 to 14 carbon atoms, each of which group may have 1 to 2 substituents selected from the group consisting of a halogen atom and an alkoxy group having 1 to 3 carbon atoms, (4) halogen atom, (5) an acyl group which may have 1 to 3 substituents selected from the group consisting of a C (6) nitro group, and (7) an amino group optionally mono- or di-substituted by alkyl group having 1 to 10 carbon atoms, alkenyl group having 2 to 10 carbon atoms, cycloalkyl group having 3 to 10 carbon atoms, cycloalkenyl group having 3 to 10 carbon atoms, aryl group having 6 to 14 carbon atoms or acyl group having 1 to 13 carbon atoms; U is a bond; W is an alkylene group having 1 to 20 carbon atoms; and R