Patent ID: 8848051
Filing Date: 2014-09-30
Classification: G01N,G06T

Abstract:
1. A method of scanning a biochip, the method comprising: measuring three-dimensional locations of at least three different positions on a surface of the biochip, wherein the biochip comprises two or more panels and each panel comprises a microarray, wherein the two or more panels are adjacent to each other and the at least three different positions comprise target marks on the surface of the biochip, wherein measuring includes focusing a camera on the target marks, wherein the measured three-dimensional locations of the target marks are calculated based on a degree of motion of a stage on which the biochip is disposed; determining one of a virtual approximation plane and a curved surface with respect to the surface of the biochip based on the measured three-dimensional locations; determining a degree of rotation of the biochip relative to a scanning direction and imaging locations of the two or more panels disposed on the biochip based on the one of the virtual approximation plane and the curved surface; obtaining individual images of the two or more panels by scanning the biochip based on the determined imaging locations, wherein scanning includes adjusting a position of one of the camera or the biochip in the scanning direction and in a first direction orthogonal to the scanning direction during the scanning in the scanning direction and, if the degree of rotation is larger than a predetermined angle, in a second direction orthogonal to the scanning direction during the scanning in the scanning direction, wherein the first direction and the second direction are orthogonal; and extracting overall data of the biochip from the individual images of the two or more panels, wherein the extracting of the overall data of the biochip comprises: performing a gridding operation on an individual image of one of the panels so as to coordinate locations of spots of a microarray in an individual panel and to evaluate a brightness of each of the spots; sequentially performing the gridding operation on individual images of the other panels; and extracting data of the entire biochip from results of the gridding operation performed on the individual images of the panels.