Patent ID: 8383125
Filing Date: 2013-02-26
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An antimicrobial peptide fragment of a tammar wallaby milk protein comprising the sequence as set forth in SEQ ID NO: 2, or an antimicrobial derivative or analog thereof comprising a sequence selected from SEQ ID NO: 9, 11, 13 and 17, wherein SEQ ID NO: 9 has the same amino acid sequence as SEQ ID NO: 2 with substitution of all L-amino acids for all D-amino acids, wherein SEQ ID NO: 11 has the same amino acid sequence as SEQ ID NO: 2 with substitution of N and C terminal L-amino acids for D-amino acids, and wherein said peptide fragment, derivative or analog has enhanced activity against one or a plurality of gram-negative bacteria relative to an equivalent amount of LL-37 peptide comprising amino acid residues 104-140 of the 18-kDa human cationic antimicrobial protein (hCAP18) as determined by minimal inhibitory concentration (MIC) of the peptide, derivative or analog against said one or more gram negative bacteria compared to LL-37.