Patent ID: 6486141
Filing Date: 2002-11-26
Classification: A61P,C07F

Abstract:
A compound represented by formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein:R1 and R2 are selected from the group consisting of: C1-10alkyl(Ra)0-7, C2-10alkenyl(Ra)0-7, Aryl(Ra)0-3 and Het(Ra)0-3; wherein, each Ra independently represents a member selected from the group consisting of: Aryl, OH, halogen, C0-6alkyleneCO2H, C0-6alkyleneCO2C1-6alkyl, OC1-10alkyl, C1-6alkyl, C1-6haloalkyl, OC1-10alkyleneCO2H, S(O)yC1-6alkyl, S(O)yNR3â€²R4â€², and Het, wherein y is 0, 1, or 2; Ar represents Aryl or Het, wherein said Aryl or Het is substituted with 1-5 substituents Rb, wherein optionally 2 Rb groups can join together to form a 5-7 membered ring fused to Ar, where the fused portion of the 5-7 membered ring may be saturated or may include 1-2 double bonds and may include 1-4 heteroatoms selected from N, S, O, and C(&boxH;O) in the fused portion of the ring, said ring optionally being substituted with 1-3 groups independently selected from Ra; Aryl is a 6-14 membered carbocyclic aromatic ring system comprising 1-3 phenyl rings, wherein said rings are fused together when there is more than one aromatic ring; Het represents a 5-10 membered aromatic ring system comprising one ring or two fused rings, 1-4 heteroatoms, 0-4 of which are N atoms and 0-2 of which are O or S(O)y wherein y is 0-2, and 0-2 carbonyl groups; Each y is 0, 1 or 2; Each Rb is independently selected from the group consisting of: OH, CN, halogen, C0-6alkyleneOC1-6alky](Ra)0-7, C0-6alkyleneOAryl(Ra)0-7, Het, C0-6alkyleneS(O)yC1-6alkyl(Ra)0-7, with y equal to 0-2, C0-6alkyleneS(O)3H, C1-10alkyl(Ra)0-7, N3, C0-6alkyleneCO2H, C0-6alkyleneCO2C1-6alkyl(Ra)0-7, C0-6alkyleneCO2C2-6 alkenyl(Ra)0-7, C0-6alkyleneC(O)C1-6alkyl(Ra)0-7, C(O)NR3â€²R4â€², s(O)yNR3â€²R4â€², NR3â€²R4â€², PO(OR5)2, and CF2PO(OR5)2, wherein R3â€² and R4â€² are as defined above; Each R5 is H; Y1, Y2, Z1 and Z2 each independently represents â€”(CR3R4)aâ€”Xâ€”(CR3R4)bâ€” wherein a and b are each zero or an integer 1 or 2 such that the sum of a and b equals 0, 1, 2 or 3, X represents a bond, O, S(O)y, NR3â€², C(O), OC(O), C(O)O, C(O)NR3â€², NR3â€²C(O) or â€”CH&boxH;CHâ€”, where y is as previously defined; R3 and R4 are independently H, halogen, C1-10alkyl or C1-10haloalkyl; R3â€² is selected from the group consisting of: H, C1-6alkyl, C1-6haloalkyl, OH, C(O)C1-6 alkyl, C(O)Aryl, C(O)Het, C(O)C1-6 haloalkyl, Aryl and Het; R4â€² is selected from the group consisting of: H, C1-6alkyl, C1-6haloalkyl, Aryl and Het; Each W1 is independently selected from the group consisting of: H, OH, CN, halogen, OC1-6alkyl(Ra)0-7, OAryl(Ra)0-7, S(O)yC1-6alkyl(Ra) with y equal to 0-2, S(O)3H, C1-6alkyl(Ra)0-7, N3, C0-6alkyleneCO2H, C0-6alkyleneCO2C1-6alkyl(Ra)0-7, C0-6alkyleneCO2C2-6 alkenyl(Ra)0-7, C0-6alkyleneC(O)C1-6alkyl(Ra)0-7, C(O)NR3â€²R4â€², S(O)yNR3â€²R4â€², NR3â€²R4â€², Aryl and Het, wherein R3â€² and R4â€² are as defined above; or alternatively two W1 groups on adjacent atoms of the aromatic ring are joined together to form a fused phenyl ring, optionally substituted with 1-3 groups Rb.