Patent ID: 6914058
Filing Date: 2005-07-05
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein R 1 represents halo, azido, thioalcohol, isothiocyanate, isoindole-1,3-dione, NHR 4 where R 4 represents hydrogen atom, or substituted or unsubstituted groups selected from (C 1 -C 10 )alkyl, (C 1 -C 10 )acyl, thio(C 1 -C 10 )acyl, (C 1 -C 10 )alkoxycarbonyl, (C 3 -C 10 )cycloalkoxythiocarbonyl, (C 2 -C 10 )alkenyloxycarbonyl, (C 2 -C 10 )alkenylcarbonyl, heteroaryl, aryloxycarbonyl, heteroarylcarbonyl, heteroarylthiocarbonyl, (C 1 -C 10 )alkoxythiocarbonyl, (C 2 -C 10 )alkenyloxythiocarbonyl, aryloxythiocarbonyl, —C(═O)—C(═O)—(C 1 -C 10 )alkyl, —C(═O)—C(═O)-aryl, —C(═O)—C(═O)—(C 1 -C 10 )alkoxy, —C(═O)—C(═O)-aryloxy, —C(═O)—C(═S)—(C 1 -C 10 )alkyl, —C(═O)—C(═S)-aryl, —C(═S)—S—(C 1 -C 10 )alkyl, —C(═S)—NH 2 , —C(═S)—NH—(C 1 -C 10 )alkyl, —C(═S)—N—((C 1 -C 10 )alkyl) 2 , —C(═S)—NH—(C 2 -C 10 )alkenyl, —C(═S)—C(═O)—(C 1 -C 10 )alkoxy, —C(═S)—C(═O)-aryloxy, —C(═S)—O—C(═O)—(C 1 -C 10 )alkyl, —C(═S)—C(═S)—(C 1 -C 10 )alkyl, —C(═S)—C(═S)-aryl, —C(═S)—NH—C(═O)-aryl, —C(═S)—NH-aralkyl, —C(═S)—NH-heteroaralkyl, —C(═NH)—NH 2 , —C(═NH)—(C 1 -C 10 )alkyl, —C(═NH)-aryl, —S(O) 2 (C 1 -C 10 )alkyl, —S(O) 2 aryl, thiomorpholinylthiocarbonyl, pyrrolidinylthiocarbonyl or —C(═S)—N(R′R″), where R′ and R″ together form a substituted or unsubstituted 5 or 6 member heterocycle ring containing nitrogen and optionally having one or two additional hetero atoms selected from O, S or N; OR 5 where R 5 represents hydrogen, substituted or unstubstituted groups selected from (C 1 -C 10 )acyl, heteroaryl, S(O) 2 (C 1 -C 10 )alkyl, S(O) 2 aryl or —C(═S)—S—(C 1 -C 10 )alkyl; N(R 6 ) 2 , where —(R 6 ) 2 together represent a substituted or unsubstituted 5 or 6 member heterocycle ring containing nitrogen and optionally having one or two additional hetero atoms selected from O, S or N; R 2 and R 3 are the same or different and independently represent hydrogen, halogen atom, substituted or unsubstituted (C 1 -C 10 )alkyl group, halo(C 1 -C 10 )alkyl, cyano, nitro, SR a , NR a , or OR a where R a represents substituted or unsubstituted (C 1 -C 10 )alkyl group; Z represents S, S(O) n where n represents 1-2, —S═NR, or —S(═O)═NR, wherein R represents hydrogen or substituted or unsubstituted (C 1 -C 10 )alkyl; Y 1 , Y 2 and Y 3 are the same or different and independently represent hydrogen, halogen, cyano, nitro, formyl, hydroxy, amino or substituted or unsubstituted groups selected from (C 1 -C 10 )alkyl, hydroxy(C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy(C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxycarbonyl, carboxy(C 1 -C 10 )alkyl, (C 1 -C 10 )alkylsulfonyl, (C 1 -C 10 )alkylcarbonylamino (C 1 -C 10 )alkyl, arylcarbonylamino(C 1 -C 10 )alkyl, (C 1 -C 10 )alkylcarbonyloxy(C 1 -C 10 )alkyl, amino(C 1 -C 10 )alkyl, mono(C 1 -C 10 )alkylamino, di(C 1 -C 10 )alkylamino, arylamino, (C 1 -C 10 )alkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl or heterocycloalkyl; or any one or two of Y 1 , Y 2 or Y 3 represent ═O, ═S, substituted or unsubstituted ═NOH; or group; its tautomeric forms, its stereoisomers, its polymorphs, it rotamers, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates.