Patent ID: 9012517
Filing Date: 2015-04-21
Classification: A61K,A61L,A61P

Abstract:
1. A method for making a hydrogel for soft tissue augmentation, the method comprising: providing at least one cross-linkable biocompatible polymer; dissolving said at least one cross-linkable biocompatible polymer in a buffered solution, wherein said buffered solution maintains a pH from approximately 6.0 to approximately 8.0; adding at least one zero-length cross-linking agent to said buffered solution to form a reaction mixture; and allowing said reaction mixture to stand for a time appropriate to form the hydrogel suitable for soft tissue augmentation, wherein said hydrogel comprises a cross-linked biocompatible polymer having zero-length cross-linked moieties; wherein at least one said cross-linkable biocompatible polymer is hyaluronic acid; and wherein said zero-length cross-linking agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC).