Patent ID: 9109040
Filing Date: 2015-08-18
Classification: A61K,A61P,C07K,G01N,Y02A

Abstract:
1. A recombinant combination vaccine composition comprising an isolated and/or recombinant first and second polypeptide, wherein the first polypeptide comprises an amino acid sequence comprising SEQ ID NO: 2 or an antigenic fragment thereof, or an amino acid sequence of SEQ ID NO: 2 comprising one or more point mutations selected from the group consisting of: N at amino acid position 144 replaced with K, V at amino acid position 190 replaced with A, H at amino acid position 511 replaced with R, L at amino acid position 673 replaced with V, A at amino acid position 755 replaced with G, Y at amino acid position 985 replaced with N, and I at amino acid position 1039 replaced with M; and wherein said second polypeptide consists of SEQ ID NO: 36 or consists of SEQ ID NO: 36 having one or more point mutations selected from the group consisting of: S at amino acid position 9 replaced with N, E at amino acid position 164 replaced with K, K at amino acid position 173 replaced with E, E at amino acid position 299 replaced with V, and G at amino acid position 341 replaced with D; and an immunologically effective amount of an adjuvant.