Patent ID: 7337066
Filing Date: 2008-02-26
Classification: G01N

Abstract:
1. A method for adjusting a baseline for a Raman spectrum comprising: (a) providing a Raman spectrum having plural data points wherein each data point has a value associated therewith; (b) determining a first set of said data points to be baseline data points; (c) determining a second set of said data points to be baseline data points wherein said second set of data points is not contiguous with said first set of data points; (d) bridging a gap between said first and second set of data points with a straight line to thereby form an estimated baseline; (e) smoothing said estimated baseline to thereby form a smoothed baseline; and (f) subtracting said smoothed baseline from said Raman spectrum to thereby provide an adjusted-baseline Raman spectrum, wherein step (b) further comprises (b)(i) determining a first quantity as a function of a maximum and a minimum of the value of the data points in a first group of data points; (b)(ii) determining a second quantity as a function of a signal to noise ratio of the Raman spectrum and as a function of a weighted standard deviation for the value of the data points in a second group of data points; and (b)(iii) for ones of said data points, comparing the first quantity to the second quantity to thereby determine a first set of data points to be baseline data points.