Patent ID: 8084592
Filing Date: 2011-12-27
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
1. An immunogenic product comprising a plurality of compositions comprising one or more nucleic acid compositions and one or more peptide compositions; wherein the one or more nucleic acid compositions are capable of expressing two or more class I MHC restricted epitopes, wherein the two or more class I MHC restricted epitopes comprise a PRAME epitope and a PSMA epitope, wherein the PRAME epitope is selected from PRAME 425-433 (SEQ ID NO. 3) or a cross-reactive analogue thereof, and wherein the PSMA epitope is selected from PSMA 288-297 (SEQ ID NO. 4) or a cross-reactive analogue thereof, and wherein the one or more peptide compositions comprise one or more class I MHC restricted epitopes, wherein the one or more class I MHC restricted epitopes comprise the PRAME epitope or the PSMA epitope or both, and wherein PRAME epitope is selected from PRAME 425-433 (SEQ ID NO. 3) or a cross reactive analogue thereof and the PSMA epitope is selected from PSMA 288-297 (SEQ ID NO. 4) or a cross reactive analogue thereof.