Patent ID: 6506732
Filing Date: 2003-01-14
Classification: A61K

Abstract:
A crude fraction of a hydrolysate of casein-containing milk proteins comprising a mixture of peptides obtained by hydrolysis of said milk proteins with at least one of pepsin or chymotrypsin to a degree of hydrolysis of 1 to 10%, and subsequent fractionation to obtain a fraction having a molecular weight ranging from 200 daltons to 1400 daltons and a hydrophobicity of about 11 Kcal/mole, said peptides being constituted of at least 66% hydrophobic amino acids and 17% aromatic amino acids, and having aromatic amino acids and other hydrophobic amino acids located at the C- and N-terminal endings in proportion over 85%, said peptides having low allergenicity and a percutaneous absorption of about 5%, wherein said fraction increases the growth rate of human keratinocytes in vitro culture by at least 50%, and wherein said fraction is substantially free from free amino acids.