Patent ID: 6592872
Filing Date: 2003-07-15
Classification: A61K,C07K,C12N,Y02A,Y10S

Abstract:
A method of immunizing a mammal against cytotoxic T cell epitopes of a specific full length protein antigen, the method comprising the step of administering a safe and effective amount of a binary, cytotoxic T lymphocyte vaccine comprising an anthrax protective antigen and the full length protein antigen bound to a nontoxic anthrax protective antigen binding protein comprising at least about the first 250 amino acid residues of the lethal factor of Bacillus anthracis and less than all of the amino acid residues of the lethal factor, wherein the full length protein antigen is processed into multiple epitopes in a cytosolic MHC class I processing pathway and presented by MHC class I molecules to cytotoxic T lymphocytes.