Patent ID: 6172065
Filing Date: 2001-01-09
Classification: C07D

Abstract:
A compound of Formula I ##STR42##or a pharmaceutically acceptable salt thereof whereinR is a urea or thiourea of formula ##STR43##wherein X is O or S;R.sub.11 is methyl hydrogen, alkyl, aralkyl, aryl, hydroxyl, hydroxyalkyl, alkoxyalkyl;R.sub.12 is hydrogen, alkyl, aralkyl, aryl, hydroxyl, alkoxyl, hydroxyalkyl, alkoxyalkyl, alkenyl, alkynyl, alkenylalkyl, alkynylalkyl, --SO.sub.2 R.sub.14, --(CH.sub.2).sub.n SO.sub.2 R.sub.14, --(CH.sub.2).sub.n CO.sub.2 R.sub.17, --(CH.sub.2).sub.n CONR.sub.18 R.sub.19, --CH(R.sub.20)C(O)OR.sub.17 or --CH(R.sub.20)C(O)NR.sub.18 R.sub.19, wherein R.sub.14 is hydroxy, alkoxy, or --NR.sub.15 R.sub.16 ; R.sub.15, R.sub.16, R.sub.18 and R.sub.19 are independently selected from hydrogen, alkyl, aralkyl and aryl; R.sub.17 is hydrogen, alkyl, aralkyl; and R.sub.20 is hydrogen;R.sub.13 is hydrogen;n is an integer of from 1 to 4;R.sub.1 is hydrogen, alkyl, aralkyl, carboxyalkyl, phosphoroalkyl, or phosphonoalkyl;R.sub.2 is hydrogen, hydroxy, or amino;R.sub.3 is hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, nitro, cyano, SO.sub.2 CF.sub.3, CH.sub.2 SO.sub.2 R.sub.6, (CH.sub.2).sub.m CO.sub.2 R.sub.6, (CH.sub.2).sub.m CONR.sub.7 R.sub.8, (CH.sub.2).sub.m SO.sub.2 NR.sub.7 R.sub.8, or NHCOR.sub.6 wherein m is an integer of from 0 to 4, and R.sub.6, R.sub.7, and R.sub.8 are each independently selected from hydrogen, alkyl, haloalkyl, or aralkyl;R.sub.4 is nitro;R.sub.5 is methyl;m is an integer of from 0 to 4;R.sub.9 and R.sub.10 are each independently hydrogen, alkyl, haloalkyl, or aralkyl.