Patent ID: 6057287
Filing Date: 2000-05-02
Classification: A61K,A61P,C07K,G01N

Abstract:
A kallikrein binding protein of 56-60 amino acids comprising a non-naturally occurring Kunitz domain, said Kunitz domain having disulfide bonds at Cys5-Cys55, Cys14-Cys38, and Cys30-Cys51 and further having:amino acid number 13 selected from His and Pro;amino acid number 14 Cys;amino acid number 16 selected from Ala and Gly;amino acid number 17 selected from Ala, Asn, and Ser;amino acid number 18 selected from His and Leu; andamino acid number 19 selected from Gln, Leu, and Pro,wherein the above amino acids are numbered to correspond to the numbering of amino acid residues of bovine pancreatic trypsin inhibitor (BPTI) (SEQ ID NO:1).