Patent ID: 7670770
Filing Date: 2010-03-02
Classification: B01J,B01L,B81B,B81C,B82Y,C12Q,G01N,Y10S

Abstract:
1. A method of isolating, imaging, and analyzing, in parallel, two or more individual nucleic acid biopolymers, comprising the steps of: providing a nanofluidic chip, comprising: providing the at least one sample reservoir with at least one fluid, said fluid comprising at least two nucleic acid biopolymers; transporting the at least two nucleic acid biopolymers into the at least two nanochannels to elongate said at least two nucleic acid biopolymers, the at least two nucleic acid biopolymers being individually confined within the at least two nanochannels such that the at least two nucleic acid biopolymer are transported through the at least two nanochannels in an unfolded fashion; imaging in parallel at least one signal transmitted from the at least two elongated and isolated nucleic acid biopolymers within the nanochannels; and correlating the signal to at least one property of the at least two nucleic acid biopolymers to thereby analyze the two or more individual nucleic acid biopolymers.