Patent ID: 9139597
Filing Date: 2015-09-22
Classification: A61P,C07D

Abstract:
1. A method for the production of a compound of the general formula (1) comprising the steps: (a) reacting a compound of the formula (3) wherein Q 1 and Q 2 independently of each other represents a hydrogen atom or a silyl group, with a compound of the formula (4) wherein R represents an amino-protective group, to produce a compound of the formula (5) wherein Q 1 , Q 2 and R are as defined above; (b) reacting the compound of the formula (5) with a compound of the formula (6) wherein R 1 represents a hydroxy-protective group and Y represents an activating functionality, wherein after optional removal of the protective group, if Q 1 represents a silyl group, to provide a compound of the formula (7) wherein R 1 , Q 2 and R are as defined above; converting the compound of the formula (7) into the compound of the formula (2) wherein for the reaction according to step (b) the compound of the formula (5) is dissolved by silylation or salt formation and step c) is carried out without intermediate isolation of the intermediate obtained from step b) and (d) converting the compound of the formula (2) into a compound of the formula (1).