Patent ID: 6897222
Filing Date: 2005-05-24
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein R R R R R R wherein substituted aryl is aryl that is mono-, di- or tri-substituted by lower alkyl, lower alkoxy, halo, cyano, azido, amino, di-lower alkyl amino or hydroxy; substituted heteroaryl is heteroaryl that is mono-, di- or tri-substituted by halogen, amino, perfluoro-lower alkyl, lower alkyl or lower alkoxy; substituted heterocyclyl is heterocyclyl that is mono-, di- or tri-substituted by lower alkyl, lower alkoxy, halo, cyano, azido, amino, di-lower alkyl amino or hydroxyl; and pharmaceutically acceptable salts thereof; with the exception of rac-3β-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bβ-hexahydro-2H-pyrido[2,1-a]isoquinolin-2β-ylamine dihydrochloride, rac-3β-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bβ-hexahydro-2H-pyrido[2,1-a]isoquinolin-2α-ylamine dihydrochloride, 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine, rac-3β-methyl-9,10-dimethoxy-1,3,4,6,7,11bβ-hexahydro-2H-pyrido[2,1-a]isoquinolin-2β-ylamine dihydrochloride, rac-3β-methyl-9,10-dimethoxy-1,3,4,6,7,11bβ-hexahydro-2H-pyrido[2,1-a]isoquinolin-2α-ylamine dihydrochloride, and 3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine.