Patent ID: 7652044
Filing Date: 2010-01-26
Classification: A61P,C07D

Abstract:
1. A method of treating rheumatoid arthritis, comprising administering a compound of formula (I): or pharmaceutically acceptable derivatives thereof, wherein: R R n is 0, 1 or 2; R Y is —C(═O)NH—; Z is NR B is 1,3-thiazole; 1,2,4-triazole; 1,2,4-thiadazole; 1,3-oxazole or 1,2,4-oxadiazole optionally substituted with up to two R Q is independently selected from a single bond, —O—, —S—, —NR D is a monocyclic or bicyclical ring system optionally containing up to four heteroatom's selected from N, O, and S, and wherein a CH w is an integer having a value from 0-4; R E is selected from H, halogen, NO m is an integer having a value from 2-6; p is an integer having a value from 1-3; q is an integer having a value from 0-3; r is an integer having a value from 0-6; R R R R R R