Patent ID: 9119875
Filing Date: 2015-09-01
Classification: A61K

Abstract:
1. A porous silica particle for medical imaging, the porous silica particle comprising: a bridged silane fluorescent dye incorporated throughout a matrix of the porous silica particle via a copolymerization reaction between a bridged silane fluorescent dye and a tetralkoxysilane in the presence of a surfactant, wherein the bridged silane fluorescent dye has the general chemical structure (R′O) a surface modifier bonded onto a surface of the porous silica particle, wherein the surface modifier is selected to increase dispersion of the porous silica particle in an aqueous media, and wherein the surface modifier comprises poly(ethylene glycol); an additional functionality within the pores of the porous silica particle, wherein the additional functionality comprises at least one of an imaging material and a pharmaceutical drug, and wherein the bridged silane fluorescent dye comprises 4.4′-bis-(4-(triethoxysilyl)styryl)biphenyl.