Patent ID: 7621875
Filing Date: 2009-11-24
Classification: A61B

Abstract:
1. A non-invasive method of detecting arterial disease in vivo, comprising: obtaining acoustic signals from one or more sensors held on an external body region proximate at least one artery; generating a complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals; providing a predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease; providing a predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease; and determining whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease, wherein the arterial disease is selected from the group consisting of plaque, deposits, stenosis, occluded, obstructed blood flow, arterial hardening, arterial wall thickness perturbations, thickening of arterial junctions, emboli, blood clots, aneurysms and combination thereof.