Patent ID: 6100393
Filing Date: 2000-08-08
Classification: C12P

Abstract:
In a process for the purification of a mixture of reaction products comprising a 7-substituted aminodesacetoxycephalosporin, wherein the mixture is formed from a penicillin sulphoxide in a ring expansion reaction that produces the reaction mixture as an aqueous solution comprising said desacetoxycephalosporin and contaminating by-products of said ring expansion reaction, said penicillin sulphoxide comprising the following formula I: ##STR3## wherein R.sub.1 is H; R.sub.2 is phenylacetyl, phenoxyacetyl, hexenoyl, 2-hexenoyl, 3-hexenoyl or octanoyl; R.sub.3 is H, a monovalent cation, or an alkyl having 1-3 C atoms, the improvement comprising the step of filtering said aqueous solution through a membrane that filters contaminating by-products having a molecular weight above 10,000 Daltons from the aqueous solution to form a filtered solution comprising a purified desacetoxycephalosporin.