Patent ID: 7378432
Filing Date: 2008-05-27
Classification: A61K,A61P,C07F,C07K,C12N

Abstract:
1. A compound of the formula: wherein the phosphate group and the guanidine group are attached at any position of their respective phenyl ring; said compound having a negatively charged phosphate group and at least one guanidino moiety-containing group being covalently linked therebetween via a spacer, said spacer having a length, structure and flexibility selected for allowing at least one interaction between said phosphate group and a first binding site in a catalytic domain of a GSK-3 and at least one interaction between said guanidino moiety-containing group and a second binding site in said catalytic domain of a GSK-3, such that the compound is capable of inhibiting a catalytic activity of a GSK-3.