Patent ID: 7223726
Filing Date: 2007-05-29
Classification: A61K,C07K

Abstract:
1. An isolated functional mutant Apolipoprotein A-I (Apo A-I) protein, comprising an amino acid sequence of SEQ ID NO:3, having a mutation comprising the substitution of at least one amino acid residue of said function mutant Apo A-I protein with cysteine at a residue position selected form the group consisting of 7, 10, 13, 17, 20, 22, 27, 30, 33, 39, 45, 49, 54, 58, 61, 96, 123, 131, 215, or 238, whereby said functional mutation ApoA-I protein has a specific effect on paraoxonase activity, wherein said functional mutant retains the amphipathic helical structure that is functionally required for mediating HDL assembly and determining HDL structure and composition.