Patent ID: 7378428
Filing Date: 2008-05-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) wherein R Z is —CR R R R Cyc1, which is represented by R R R R R R R R R R R R R R R (hereinafter it is abbreviated as ring;) is Cyc2 wherein the group which attaches to carbonyl is carbon; R Cyc2 may be substituted with 1-5 of R R R R R R R R R R R Cyc3 is (1) C3-15 mono-, bi- or tri-cyclic (fused or spiro)carboring, or (2) 3-15 membered mono-, bi- or tri-cyclic (fused or spiro)heteroring comprising 1-4 of heteroatom selected from oxygen, nitrogen and sulfur; Cyc3 may be substituted with 1-5 of R R R R R R R R R n is an integer of 1 or 2; R R R R R R R R R R R wherein R wherein R wherein R R R R Cyc5 and Cyc6 may be substituted with 1-5 of R R R R R R R Cyc7 may be substituted with 1-5 group selected from (1) C1-8 alkyl, (2) C1-8 alkoxy, (3) halogen atom, or (4) nitro; Cyc8 may be substituted with R R R Cyc5, Cyc6, Cyc7 and Cyc8 are (1) C3-15 mono-, bi- or tri-cyclic (fused or spiro)carboring, or (2) 3-15 membered mono-, bi- or tri-cyclic (fused or spiro)heteroring comprising 1-4 of heteroatom selected from 1-4 of oxygen, nitrogen or sulfur; wherein when R wherein Cyc7 is not phenyl; Cyc4 is benzo; (abbreviated as dashed line a hereafter;) and (abbreviated as dashed line b hereafter;) are (1) a bond, or (2) a double bond; R 1) when dashed line a is a bond, dashed line b is a double bond, and R 2) when dashed line a is a double bond, dashed line b is a bond, and R 3) 2-(3,3-dimethyl-3,4-dihydro-(2H)-isoquinolin-1-ylidene)-1-phenylethan-1-one is excluded, or a pharmacologically acceptable salt thereof.