Patent ID: 6218373
Filing Date: 2001-04-17
Classification: A61K

Abstract:
A method of manufacturing a pharmaceutical composition from which effective non-toxic dosage amounts may be taken comprising admixing:(1) a therapeutically effective amount of a drug for the topical treatment of a disease or condition of the skin and exposed tissue, said drug selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID) and a chemotherapeutic drug with;(2) a sufficient amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and its pharmaceutically acceptable salts and combination thereof characterized in that said composition when manufactured comprises 3% by weight of the drug, 21/2% by weight of a form of hyaluronic acid having a molecular weight less than about 750,000 daltons and greater than 150,000 daltons, a solubilizer for solubilizing the drug, and optionally a preservative and the dosage amounts can be taken from the composition in which dosage amounts of component (2) exceeds 5 mg/cm.sup.2 of the skin or exposed tissue to which the dosage amount is to be applied, the composition being in such form that component (2) is immediately available to transport component (1) percutaneously into the epidermis of the skin or exposed tissue to the site of trauma or pathology of the disease or condition to be treated in the skin or exposed tissue, where the dosage amount of the composition accumulates (in the epidermis) for a prolonged period before passage therefrom.