Patent ID: 6680175
Filing Date: 2004-01-20
Classification: A61K,C07K,Y10S

Abstract:
A method for determining the presence of invasive ovarian or breast cancer cells in a biological sample of a cancer patient, comprising the steps of:(a) contacting a biological sample obtained from the cancer patient with a binding agent that specifically binds to an OB-cadherin that comprises SEQ ID NO:4 or SEQ ID NO:5 and modulates cell adhesion of OB-cadherin-expressing cells; and (b) detecting in the sample an amount of polypeptide that binds to the binding agent, relative to a predetermined cut-off value, and therefrom determining the presence of invasive cancer cells in the biological sample wherein the binding agent is selected from the group consisting of a CAR sequence of OB-cadherin, a monoclonal antibody or a polyclonal antibody.