Patent ID: 7655431
Filing Date: 2010-02-02
Classification: A61P,C07K,C12Q

Abstract:
1. A substantially pure polypeptide comprising the amino acid sequence ARTKQ (SEQ ID NO:4), wherein: a) said polypeptide is 5-135 amino acids in length; b) said polypeptide inhibits the phosphorylation of human histone H3 by haspin; c) said polypeptide is not itself histone H3; d) said polypeptide optionally includes an additional methionine as the N terminal amino acid; and e) said polypeptide is present in a solution that further comprises human haspin (SEQ ID NO:17) and a phosphorylated polypeptide that has an amino acid sequence identical to said polypeptide but in which the threonine in said ARTKQ sequence has been phosphorylated.