Patent ID: 6815435
Filing Date: 2004-11-09
Classification: A61K,A61P

Abstract:
A pharmaceutical composition containing a compound wherein a polysaccharide derivative having a carboxyl group is bonded to (1S,9S)-1-amino-9-ethyl-5-fluoro-2, 3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo[de]pyrano[3â€²,4â€²:6,7]indolizino[1,2-b]quinoline-10,13(9H,15H)-dione via a spacer consisting of one amino acid or a spacer consisting of 2 to 8 amino acids bonded to each other via peptide bonds, or a compound wherein a polysaccharide derivative having a carboxyl group is bonded to (1S,9S)-1-amino-9-ethyl-5-fluoro-2, 3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo[de]pyrano[3â€²,4â€²:6,7]indolizino[1,2-b]quinoline-10,13(9H,15H)-dione without mediated by any spacer and maltose, in which molecular weight increase and change in appearance of the compounds are reduced during preservation of the compound.