Patent ID: 6713580
Filing Date: 2004-03-30
Classification: C07B,C07C,C07D

Abstract:
A compound of the following formula whereinZ comprises the residue of a solid polymer support having hydroxyl or amino functionality; L1 comprises a divalent group of the formula â€”Oâ€”, â€”NHâ€”, â€”Oâ€”CH2â€”C6H4â€”CH2Oâ€”; L2 and L3 comprise, independently, alkylene, alkenylene, alkynylene, or a direct single bond; L4 comprises alkylene, â€”Oâ€”, â€”Sâ€”, â€”C(O)â€”, â€”S(O)â€”, â€”S(O)2â€”, â€ƒor a direct single or double bond; L5 comprises â€”CH2CH2â€” or â€”CH2CH2CH2â€”; E and K comprise, independently, â€”Nâ€”, â€”CHâ€”, or â€”C&boxH;; PG comprises hydrogen or an amino protecting group; R1 and R2 comprise, independently, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, hydrogen, halo, â€”Oâ€”G3, â€”Oâ€”G4, â€”G3, â€”G4, or â€”N(G3)G4; R1 and R2 may be taken together to constitute a cycloalkyl or heterocyclyl ring, or, where L4 is a direct bond, R1 and R2 may be taken together to constitute a fused aryl or heteroaryl ring; G3 and G4 comprise, independently, whereL7, L8, L9, L10, L11, L12 comprise, independently, alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, arylene, heterocyclylene, heteroarylene, fused cycloalkylarylene, fused cycloakylheteroarylene, fused heterocyclylarylene, fused heterocyclylheteroarylene, or a direct bond; and R10, R11, R12, R13, R14, R15 comprise, independently, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, aryl, fused cycloalkylaryl, fused cycloakylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, â€”NR18R19, â€”OR18, â€”SR18, or hydrogen, where R18 and R19 are as defined below; R18 and R19 comprise, independently, hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, or heteroaryl.