Patent ID: 6162820
Filing Date: 2000-12-19
Classification: A01N,A61K,A61P

Abstract:
A composition for oral administration comprising:(i) an ectoparasiticidally effective amount of compound of formula (I) ##STR4## in which: R.sub.1 is a halogen atom, CN or methyl;R.sub.2 is S(O).sub.n R.sub.3 or haloalkyl;R.sub.3 is alkyl or haloalkyl;R.sub.4 represents a hydrogen or halogen atom; or an NR.sub.5 R.sub.6, S(O).sub.m R.sub.7, C(O)R.sub.7, or C(O)OR.sub.7, alkyl, haloalkyl or OR.sub.8 radical or a --N.dbd.(R.sub.9)(R.sub.10) radical;R.sub.5 and R.sub.6 independently represent a hydrogen atom or an alkyl, haloalkyl, alkoxycarbonyl, C(O)alkyl, or S(O).sub.r CF.sub.3, radical; or R.sub.5 and R.sub.6 may together form a divalent alkylene radical which may be interrupted by one or two divalent heteroatoms such as oxygen or sulfur;R.sub.7 represents an alkyl or haloalkyl radical;R.sub.8 represents an alkyl or haloalkyl radical or a hydrogen atom;R.sub.9 represents an alkyl radical or a hydrogen atom;R.sub.10 represents a phenyl or heteroaryl group optionally substituted with one or more halogen atoms or groups such as OH, --O-alkyl, --S-alkyl, cyano or alkyl;R.sub.11 represents a hydrogen or halogen atom and optionally CN or NO.sub.2 ;R.sub.13 represents a halogen atom or a haloalkyl, haloalkoxy, S(O).sub.q CF.sub.3, or SF.sub.3 group;m, n, p and r represent, independently of each other, an integer equal to 0, 1 or 2;X represents a trivalent nitrogen atom or a C--R.sub.12 radical, the other three valencies of the carbon atom forming part of the aromatic ring;with the proviso that when R.sub.1 is methyl, then either R.sub.3 is haloalkyl, R.sub.4 is NH.sub.2, R.sub.11 is Cl, R.sub.13 is CF.sub.3 and X is N; and,(ii) a gastroprotective excipient; whereby, when the composition is ingested, the compound of formula (I) is released in the intestines.