Patent ID: 6534503
Filing Date: 2003-03-18
Classification: A61K,C07B,C07D,C40B,G01N

Abstract:
A method for treating sexual dysfunction in a subject, comprising the step of administering to the subject an effective dose of the compoundXâ€”X2-(D)Phe-Arg-(D)Trp-X3 whereinX1 is â€ƒCOCH3, H or absent; X2 is â€ƒHis, COCH3 or H; and X3 is â€ƒor R5; wherein R1 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph, CH2CO-(polyethylene glycol) or A; R2 is H, COCH3, C2 H5 or CH2Ph; R3 is a linear alkyl group having 1 to 6 carbon atoms or a branched or cyclic alkyl group having 3 to 6 carbon atoms; R4 is (CH2)mâ€”CONH2, (CH2)mâ€”CONHR1 or (CH2)mâ€”CONHA; R5 is OH, OR3, NH2, SH, NHCH3, NHCH2Ph or A; R6 is H or R3; R7 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph or CH2CO-(polyethylene glycol); Ph is C6H5; m is 1, 2 or 3; n is 0, 1, 2 or 3; Y1 and Y2 are independently hydrogen atoms, or are taken together to form a carbonyl or thiocarbonyl; and A is