Patent ID: 6103475
Filing Date: 2000-08-15
Classification: A61K,C07K,Y02A

Abstract:
A method of evaluating the effectiveness of a test compound for the treatment or prevention of a condition associated with a deficiency of stimulation of a human mGluR2 receptor which method comprises:a) introducing into a mammalian host cell an expression vector comprising DNA encoding a human mGluR2 receptor, wherein said receptor comprises SEQ ID NO:2;b) culturing said host cell under conditions such that the human mGluR2 receptor is expressed;c) exposing said host cell expressing the human mGluR2 receptor to a test compound; andd) measuring the change in a physiological condition known to be influenced by the binding of native ligand to the human mGluR2 receptor relative to a control in which the transfected host cell is exposed to native ligand.