Patent ID: 6020143
Filing Date: 2000-02-01
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
A method for identifying substances that affect the interaction of a presenilin-1-interacting protein with a mammalian presenilin-1 protein, or a fragment, variant or mutein of said mammalian presenilin-1 protein that binds to said presenilin-1-interacting protein, comprising:(a) providing a preparation containing: a mammalian presenilin-1 protein, or a fragment, variant or mutein of said mammalian presenilin-1 protein that binds to said presenilin-1-interacting protein; a presenilin-1-interacting protein; and a candidate substance; and(b) detecting whether said candidate substance affects said interaction of said presenilin-1-interacting protein with said mammalian presenilin-1 protein, or a fragment, variant or mutein of said mammalian presenilin-1 protein that binds to said presenilin-1-interacting protein.