Patent ID: 6350759
Filing Date: 2002-02-26
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:R1 represents hydrogen or wherein A represents hydrogen or â€”BNZ1Z2 in which B represents linear or branched (C1-C6)alkylene and Z1 and Z2 independently represent hydrogen or alkyl, (C3-C8)cycloalkyl, or optionally substituted aryl or, together with the nitrogen atom carrying them, form an optionally substituted heterocycloalkyl or heteroaryl, R2 and R3 each independently represents alkyl, (C3-C8)cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, or aminoalkyl optionally substituted on the nitrogen by one or two groups selected from alkyl, cycloalkyl, aryl, and arylalkyl or R2 and R3 together with the carbon atom carrying them, form a (C3-C8)cycloalkyl or a monocyclic heterocycloalkyl unsubstituted or substituted by alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl, R40 represents hydrogen or a group selected from optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl, or a group Q or â€”Vâ€”Q wherein V represents alkylene, alkenylene, or alkynylene, and Q represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl, R41 and R5 together form a bond or each represents hydrogen, R6, R7, R8 and R9 each independently represents hydrogen, halogen, alkyl, (C3-C8)cycloalkyl, or â€”OW wherein W represents hydrogen, alkyl, (C3-C8)cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl provided that R6, R7, R8 and R9 cannot all simultaneously represent hydrogen and that at least one of them represents â€”OW as defined hereinbefore, with the proviso that:R2 and R3 represent alkyl: if each of R6 to R9 independently represents hydrogen, alkyl or â€”OW wherein W represents alkyl, and R41 and R5 together form a bond, then R40 is other than hydrogen or alkyl, if a single group â€”OW is present in the molecule and represents hydroxy, then R40 is other than hydrogen, if a single group â€”OW is present in the molecule and represents methoxy, then R40 is other than hydroxyalkyl, the compound of formula (I) being other than 7-methoxy-2,2-diphenyl-1,2-dihydroquinoline, when R2 and R3 are methyl, R1, R41 and R5 are hydrogen, then R7 is hydrogen, halogen, alkyl, (C3-C8)cycloalkyl, or â€”OW wherein W represents hydrogen, (C2-C8)alkyl, (C3-C8)cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl, when R2 and R3, together with the carbon atom carrying them, form a cyclohexyl and R6, R7, and R8 represent hydrogen, then R8 is hydrogen, halogen, alkyl, (C3-C8)cycloalkyl, or â€”OW wherein W represents hydrogen, (C2-C8)alkyl, (C3-C8)cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl, when R2 and R3 represent alkyl and one or two of R6, R7, R8, and R9 is methoxy, then R40 represents hydrogen or a group selected from optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl, or a group Q or â€”Vâ€”Q wherein V represents alkylene, alkenylene, or alkynylene, and Q represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl, wherein alkyl may not be hydroxyalkyl, the compound of formula (I) being other than 6-methoxy-2,2-diphenyl-1,2-dihydroquinoline or 7-methoxy-2,2-diphenyl-1,2-dihydroquinoline, and an enantiomer or diastereoisomer thereof, and an addition salt thereof with a pharmaceutically-acceptable acid or base.