Patent ID: 6800642
Filing Date: 2004-10-05
Classification: A61P,C07D

Abstract:
A compound of formula I whereinR1 is hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; R2 is hydrogen, carboxy, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkoxy of one to six carbon atoms or alkyl of one to six carbon atoms; Z is NR3â€”(CH2)nâ€”Y, wherein,Y is hydrogen, hydroxy, cycloalkyl of 3 to 15 carbon atoms, or phenyl, phenoxy, naphthyl, naphthyloxy, heteroaryl, or heteroaryloxy, wherein the heteroaryl or the heteroaryl group of heteroaryloxy is selected from thienyl, furanyl, pyridinyl, indolyl, chromanyl, coumarinyl, carbostyrilyl, and quinolinyl; R3 is hydrogen or alkyl of 1 to 6 carbon atoms; n is an integer from 0 to 6; R4 is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, &ohgr;-phenylalkyl, &ohgr;-diphenylalkyl, wherein the alkyl chain contains 1 to 4 carbon atoms, indolyl, indazolyl, pyridinyl, pyrimidinyl, quinolinyl, benzoisothiazolyl, or benzisoxazolyl; R5 is hydrogen, hydroxy, cyano or carboxamido; R6 is hydrogen, 1-benzimidazol-2-onyl, benzoisothiazolyl, or benzisoxazolyl, or â€”Qâ€”Ar; Q is C&boxH;O, CHOH, or (CH2)m, m is an integer from 0 to 4; Ar is phenyl; or R5 and R6, taken together with the carbon atom to which they are attached, form R7 is hydrogen; R8 is phenyl, naphthyl, thienyl, benzoisothiazolyl, or benzisoxazolyl; or R7 and R8, taken together with the carbon atoms to which they are attached, form a benzene ring; R9 is hydrogen or alkyl of 1 to 6 carbon atoms; and R10, R11 and R12 are, independently hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof; wherein said phenyl, phenoxy, naphthyl, naphthyloxy, heteroaryloxy, &ohgr;-phenylalkyl, &ohgr;-diphenylalkyl, indolyl, indazolyl, pyridinyl, pyrimidinyl, quinolinyl, benzoisothiazolyl, benzisoxazolyl, 1-benzimidazol-2-onyl, or thienyl groups, or the benzene ring, are optionally substituted with substituents selected from hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms.