Patent ID: 6300349
Filing Date: 2001-10-09
Classification: A61K,Y02A

Abstract:
A method for the inhibition of the synthesis and release of tumor necrosis factor from various cells, comprising: administering to a human or other mammal, an effective dose of one or more pharmaceutical substances selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones, and pharmaceutically acceptable salts thereof to treat a condition selected from the group consisting of central nervous system syndromes, such as relapsing-remitting, multiple sclerosis, primary and secondary multiple sclerosis, spinal multiple sclerosis, cerebral malaria, viral or bacterial infections of the central nervous system, bacterial meningitis, ""autoimmune"" disorders of the central nervous system, central nervous system stroke and infarction, brain edema, Parkinson's syndrome, amyotrophiic lateral sclerosis, brain concussion or contusion, musculo-skeletal syndrome, such as rheumatoid arthritis, trauma-induced arthritis, arthritis caused by a microbial infection, or by a parasite, tendonitis, arthritis induced by medical products or drugs (including, small synthetic molecules as well as purified natural or synthesized peptides or proteins), pulmonary syndromes, such as acute adult respiratory distress syndrome, asthma, allergic rhinitis, allergic generalized reactions, allergic conjunctivitis, chronic obstructive pulmonary disease, and lung sarcoidosis, systemic immunologic, inflammatory, or toxic syndromes, such as endotoxemia shock syndrome, septic shock, graft-host disease following, bone-marrow transplantation, hemorrhagic shock, reperfusion injury of the brain or myocardium, thermal burns, radiation injury, general or dermal traumatic or contusion injuries, eosinophilic granuloma, diabetes mellitus (Type 11), and systemic lupus erythromatosus, and gastro-intestinal syndromes, such as Crohn's disease, ulcerative colitis, and liver inflammatory disorders.