Patent ID: 6423503
Filing Date: 2002-07-23
Classification: G01N,Y10S

Abstract:
A method for distinguishing prostate cancer from benign prostatic hyperplasia (BPH) in a subject using different forms of prostate specific antigen (PSA) contained in a sample of the subject, comprising:(a) determining the amount of a first form of PSA contained in the sample; (b) determining the amount of a second form of PSA contained in the sample; (c) determining the ratio of the first form of PSA to the second form of PSA, wherein the first form of PSA is different from the second form of PSA, and wherein the first and second forms of PSA are selected from the group consisting of proPSA, total PSA and BPSA, wherein the BPSA in said method only comprises the form of PSA that comprises at least one clip at Lysine 182 of the amino acid sequence of a mature form of PSA; and (d) correlating the ratio of step (c) to the presence of prostate cancer or BPH in the subject.