Patent ID: 7875450
Filing Date: 2011-01-25
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of generating antibodies to a self antigen in a subject to induce a physiologically effective immune response to the self antigen in the subject comprising; identifying a subject in need of antibodies to a self antigen; and providing to the subject a sufficient amount of a composition to generate antibodies to the self antigen, wherein the composition comprises a virus-like particle having an ordered assembly of subunits; and at least one B cell epitope of the self antigen joined to the virus-like particle so as to form a conjugated virus-like particle, wherein the conjugated virus-like particle displays the self antigen on the surface thereof in a regular, repetitive array to induce the subject to generate antibodies to the B cell epitope and thereby mount a physiologically effective immune response to the self antigen.