Patent ID: 8956641
Filing Date: 2015-02-17
Classification: A61K,A61P,Y02A

Abstract:
1. An implantable drug depot for treating pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease in a patient, the implantable drug depot comprising a therapeutically effective amount of alpha-2 adrenergic agonist and a polymer comprising D,L lactide having an inherent viscosity of about 0.10 dL/g to about 1.2 dL/g, the polymer comprising methyl ester end groups, ethyl ester end groups or a combination thereof; wherein the drug depot is implantable at a site beneath the skin or gum to treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease, and the depot is capable of releasing (i) about 5% to about 20% of the alpha-2 adrenergic agonist relative to a total amount of the alpha-2 adrenergic agonist loaded in the drug depot over a first period of up to 72 hours and (ii) about 21% to about 99% of the alpha-2 adrenergic agonist relative to a total amount of the alpha-2 adrenergic agonist loaded in the drug depot over a subsequent period of up to 6 months, and the alpha-2 adrenergic agonist has a particle size of from about 1to 250 microns and comprises about 5 wt. % to about 15 wt. % of clonidine hydrochloride, wherein the drug depot comprises at least one of poloxamer wherein the polymer comprises about 60 to 99% of the total weight % of the drug depot.