Patent ID: 6884802
Filing Date: 2005-04-26
Classification: A61P,C07D

Abstract:
1. A compound of formula I, in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together represent an additional bond, Het is an unsubstituted or R6- and/or R7-substituted radical selected from the group consisting of benzofuran-2-yl, benzofuran-3-yl, 2,3-dihydrobenzofuran-2-yl, 2,3-dihydrobenzofuran-3-yl, benzothiophen-2-yl, benzothiophen-3-yl, 2,3-dihydrobenzothiophen-2-yl, 2,3-dihydrobenzothiophen-3-yl, chroman-2-yl, chroman-3-yl, chroman-4-yl, isochroman-1-yl, 1,4-benzodioxan-2-yl, 1,3-benzodioxol-2-yl, quinolin-2-yl, quinolin-4-yl, quinolin-3-yl, isoquinolin-3-yl, isoquinolin-1-yl, isoquinolin-4-yl, 1,2,3,4-tetrahydroacridin-9-yl, acridin-9-yl, indolizin-2-yl, indolizin-3-yl, indolizin-5-yl, indolizin-6-yl, indolizin-7-yl, indolizin-8-yl, phenanthridin-6-yl, cinnolin-3-yl, cinnolin-4-yl, quinazolin-4-yl, quinoxalin-2-yl, phthalazin-1-yl, 1,7-naphthyridin-3-yl, 1,6-naphthyridin-3-yl, 1,6-naphthyridin-4-yl, 1,6-naphthyridin-5-yl, 1,5-naphthyridin-2-yl, 1,5-naphthyridin-3-yl, 1,5-naphthyridin-4-yl, 1,5-naphthyridin-6-yl, 1,5-naphthyridin-7-yl, 1,5-naphthyridin-8-yl, indol-3-yl, indol-2-yl, indazol-3-yl, benzimidazol-2-yl, 2,3-dihydro-1H-indol-2-yl, 2,3-dihydro-1H-indol-3-yl, 2,3-dihydro-1H-isoindol-1-yl, 2,3-dihydro-1H-isoindol-3-yl, 1,2,3,4-tetrahydroquinolin-2-yl, 1,2,3,4-tetrahydroquinolin-3-yl, 1,2,3,4-tetrahydroquinolin-4-yl, 1,2,3,4-tetrahydroisoquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-3-yl, 1,2,3,4-tetrahydroisoquinolin-4-yl, β-carbolin-1-yl, β-carbolin-3-yl, β-carbolin-4-yl, furan-2-yl, furan-3-yl, thiophen-2-yl, thiophen-3-yl, 1H-pyrrol-2-yl, 1H-pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazolyl-3-yl, thiazol-4-yl, thiazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, [1,2,3]thiadiazol-4-yl, [1,2,3]thiadiazol-5-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-2-yl, pyridazin-4-yl, pyridazin-3-yl and pyrazin-2-yl, where R6 is hydroxyl, halogen, nitro, cyano, amino, aminocarbonyl, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkyl, trifluoromethyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyloxy, 1-4C-alkylcarbonyl, 1-4C-alkoxycarbonylamino, phenyl or completely or predominantly fluorine-substituted 1-4C-alkoxy, and R7 is hydroxyl, halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy, or a hydrate, solvate, salt, hydrate of a salt, or solvate of a salt of that compound, or an N-oxide of that compound, or a hydrate, solvate, salt, hydrate of a salt or solvate of a salt thereof.