Patent ID: 6387418
Filing Date: 2002-05-14
Classification: A23L,A61K,Y10S

Abstract:
A method of ameliorating disorders in a subject associated with a condition selected from the group consisting of low-density lipoprotein oxidation, low-density lipoprotein aggregation, low-density lipoprotein retention, and macrophage oxidation of low-density lipoprotein, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein the extract is prepared by a process comprising the steps of:(a) crushing, squeezing, and enzymatically treating the whole fruits of pomegranate including inner and outer peels and the seeds to yield a juice component and an insoluble by-product component; (b) separating the juice component from the insoluble by-product component; (c) resuspending the insoluble by-product component in an aqueous medium; (d) crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion; (e) separating the soluble portion from the insoluble portion; and (f) combining the soluble portion with the juice component to produce the extract.