Patent ID: 6541502
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A compound of Formula I wherein:X is H, CF3, alkyl of 1 to 10 carbon atoms, phenyl optionally substituted with one to three substituents independently selected from alkyl of 1 to 10 carbon atoms, â€”O-alkyl of 1 to 10 carbon atoms, â€”S-alkyl of 1 to 10 carbon atoms, â€”CN, â€”NO2, and halogen; or phenylalkyl of 7 to 9 carbon atoms where the phenyl ring is optionally substituted with one to three substituents independently selected from hydroxy, amino, halogen, alkyl of 1 to 10 carbon atoms, cyano, nitro, alkylamino of 1 to 10 carbon atoms, and dialkylamino of 1 to 10 carbon atoms; R1 is H, alkyl of 1 to 10 carbon atoms, â€”CH2-cycloalkyl of 3 to 10 carbon atoms, â€”CH2-bicycloalkyl of 7 to 10 carbon atoms, R is: m is an integer of 0 to 4; R2 is H or alkyl of 1 to 10 carbon atoms; R3 is H, halogen, alkyl of 1 to 10 carbon atoms, â€”O-alkyl of 1 to 10 carbon atoms or hydroxy; Z is O, S, or â€”CH2â€”; Or R1 and R2 when taken together with the nitrogen atom to which they are attached form a moiety of the formula: n is an integer of 1 or 2; R7 and R8 are independently selected from H, halogen, alkyl of 1 to 10 carbon atoms, â€”O-alkyl of 1 to 10 carbon atoms and hydroxy; R4 and R5 are independently hydrogen, alkyl of 1 to 10 carbon atoms, â€”O-alkyl of 1 to 10 carbon atoms, â€”S-alkyl of 1 to 10 carbon atoms, â€”CN, â€”NO2, or halogen; or a pharmaceutically acceptable salt thereof.