Patent ID: 9012434
Filing Date: 2015-04-21
Classification: A61K,A61P

Abstract:
1. A method of treating menopause-related symptoms comprising administering once daily an effective amount of a pharmaceutical composition to a subject in need thereof, the pharmaceutical composition comprising: about 50 mg progesterone; about 0.25 mg estradiol or about 0.26 mg estradiol hemihydrate; about 98.24 mg of a solubilizing agent comprising monoglycerides and diglycerides containing esters of caprylic acid and capric acid (CAPMUL MCM); and about 1.50 mg of at least one of lauroyl macrogol-32 glycerides EP, lauroyl polyoxyl-32 glycerides NF, or lauroyl polyoxylglycerides (GELUCIRE 44/14); wherein a portion of the progesterone is suspended; wherein the estradiol or estradiol hemihydrate is about 90% solubilized in the solubilizing agent; and wherein the estradiol or estradiol hemihydrate and suspended progesterone are uniformly dispersed.