Patent ID: 9046534
Filing Date: 2015-06-02
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of inhibiting the growth of a tumor susceptible to growth inhibition by anti-progestins, comprising: a) obtaining a tissue sample suspected of being tumorigenic or cancerous from a patient; b) identifying progesterone receptor positive cells in the tissue sample; c) determining the degree of focal distribution of the progesterone receptor in nuclei of the progesterone positive cells from the tissue sample and identifying the binding pattern of the progesterone positive cells of the tissue; and d) administering an anti-progestin to the patient if the degree of focal distribution in the tissue sample is greater than about 5% of the progesterone receptor positive cells, wherein the anti-progestin is selected from the group consisting of onapristone, lonaprisan, mifepristone, PF-02413873, telapristone, lilopristone, ORG2058, asoprisnil, and ulipristal.