Patent ID: 8216783
Filing Date: 2012-07-10
Classification: C12Q,G01N

Abstract:
1. A method for identifying a tumor as having an increased likelihood of responding to treatment with an inhibitor of fibroblast growth factor receptor 4 (FGFR4), wherein the response comprises tumor cell death, inhibition of tumor growth, or decreased risk of metastasis of the tumor, comprising: detecting the presence of an FGFR4 protein variant in a tumor sample from a subject, wherein the FGFR4 protein variant comprises at least one of a lysine at the position corresponding to position 535 of SEQ ID NO: 2 or a glutamic acid at the position corresponding to position 550 of SEQ ID NO: 2; or detecting the presence of an FGFR4 nucleic acid variant in a tumor sample from a subject, wherein the FGFR4 nucleic acid variant encodes an FGFR4 protein comprising at least one of a lysine at the position corresponding to position 535 of SEQ ID NO: 2 or a glutamic acid at the position corresponding to position 550 of SEQ ID NO: 2, wherein the presence of the variant indicates that the tumor has an increased likelihood of responding to treatment with an inhibitor of FGFR4.