Patent ID: 6780988
Filing Date: 2004-08-24
Classification: A61P,C07H

Abstract:
A process for producing P1,P4-di(uridine 5â€²-)tetraphosphate (U2P4) or a salt thereof from uridine 5â€²-monophosphate (UMP) by reacting UMIP with diphenyl phosphorochloridate (DPC) and a pyrophosphate (PPi), which process comprises steps (a) or (b); or both (a) and (b); and (c); and optionally (d); wherein the steps are described as follows:(a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reacting UMP-DPP with a PPi-organic alkali salt to produce a reaction mixture; wherein at least one equivalent of a first base is present during one portion of the reaction; (b) reacting UMP-DPP with a PPi-organic alkali salt in the presence of at least one equivalent of a second base to produce a reaction mixture; wherein the first base and the second base may be the same or different; (c) adding water to the reaction mixture to produce an aqueous reaction mixture; and (d) adding an alkali to the aqueous reaction mixture.