Patent ID: 8987230
Filing Date: 2015-03-24
Classification: A61K,A61P

Abstract:
1. A composition comprising a hyaluronic acid having a crosslinking group(s) and a hydrophilic polysaccharide having a hydrophobic group(s), wherein the hyaluronic acid having a crosslinking group(s) is prepared by a crosslinkage formation reaction of hyaluronic acid having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide, wherein the hydrophilic polysaccharide optionally has one or more crosslinkable group(s); wherein each crosslinkable group is selected independently from the group consisting of an amino group, a mercapto group, a formyl group, a group containing a carbon-carbon double bond, a group containing a carbon-carbon triple bond, and —CONHNH wherein the hydrophilic polysaccharide is obtainable by introducing a hydrophobic group(s) into a polysaccharide selected from the group consisting of pullulan, amylopectin, amylose, dextran, mannan, levan, inulin, chitin, chitosan, and dextrin; and wherein the hyaluronic acid having a crosslinking group(s) is capable of forming a salt; wherein the hydrophilic polysaccharide has 1.38 to 30 hydrophobic groups per 100 monosaccharides; and wherein the hydrophobic group is introduced by converting one or more hydroxy groups in the hydrophilic polysaccharide into -OX, wherein X is selected from the group consisting of: —CO—X —CO—R