Patent ID: 8173161
Filing Date: 2012-05-08
Classification: A61K

Abstract:
1. A method of administering a pharmaceutical active ingredient, said method comprising chewing a treated pharmaceutical substrate comprising said pharmaceutical active ingredient, wherein said treated pharmaceutical substrate comprises a soft pharmaceutical substrate having a hardness value of from about 1 kp/cm2 to about 5 kp/cm2 wherein at least a portion of the exterior surface of said soft pharmaceutical substrate is in contact with a pharmaceutically-acceptable, water dispersible polymer layer to form a treated surface, wherein (i) the surface area of said treated surface includes at least a portion of a vulnerable edge, based upon the total surface area of the exterior surface, from about 10% to about 90%, (ii) the treated pharmaceutical substrate contains from about 3 μg to about 20 μg of polymer per square millimeter of treated surface, and (iii) the treated pharmaceutical substrate possesses immediate release properties and a friability reduction factor of at least about 2.