Patent ID: 8986689
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K

Abstract:
1. A compound comprising a single domain antibody (sdAb) capable of transmigrating across the blood brain barrier (BBB) and an analgesic peptide, wherein the antibody or fragment thereof comprises: complementarity determining region (CDR) 1 sequence HYTMG (SEQ ID NO:1); CDR2 sequence RITWGGDNTFYSNSVKG (SEQ ID NO:2); and CDR3 sequence GSTSTATPLRVDY (SEQ ID NO:3); wherein the analgesic peptide acts on opioid receptors, neuropeptide Y receptors, neurotensin receptors, galanin receptors, orexin receptors, somatostatin receptors, or any combination thereof.