Patent ID: 7956176
Filing Date: 2011-06-07
Classification: A61K,A61P,C12N

Abstract:
1. A chemically modified double stranded nucleic acid molecule that mediates RNA interference (RNAi) against a target RNA sequence, wherein: a) the nucleic acid molecule comprises a sense strand and a separate antisense strand; b) each strand of the nucleic acid molecule is independently 18 to 24 nucleotides in length; c) the antisense strand is complementary to the target RNA sequence; and d) a plurality of pyrimidine nucleotides in both the sense strand and the antisense strand are 2′-deoxy-2′-fluoro pyrimidine nucleotides, a plurality of purine nucleotides in the sense strand are 2′-deoxy purine nucleotides, and a plurality of purine nucleotides in the antisense strand are 2′-O-methyl purine nucleotides.