Patent ID: 6020347
Filing Date: 2000-02-01
Classification: C07D

Abstract:
A compound having the formula I: ##STR19## or a pharmaceutically acceptable salt thereof wherein: L is1) --C(O)--,2) --O--C(O)--,3) --NR.sup.e --C(O)--,4) --S(O).sub.2 --,5) --C(O)C(O)--;X is1) a bond or2) C(R.sup.6)(R.sup.7);Z is1) --C(O)OR.sup.d,2) --S(O).sub.m OR.sup.d,3) --C(O)NR.sup.d R.sup.h, orR.sup.1 is1) C.sub.1-10 alkyl,2) C.sub.2-10 alkenyl,3) C.sub.2-10 alkynyl,4) Cy,5) Cy-C.sub.1-10 alkyl,6) Cy-C.sub.2-10 alkenyl,7) Cy-C.sub.2-10 alkynyl,wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.2 is1) a group selected from R.sup.1 ;R.sup.3 is1) hydrogen,2) C.sub.1-10 alkyl optionally substituted with one to four substituents independently selected from R.sup.a, or3) Cy optionally substituted with one to four substituents independently selected from R.sup.b,R.sup.4 is1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, or6) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a, and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.5 is1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy-(Cy.sup.1).sub.p,6) Cy-(Cy.sup.1).sub.p -C.sub.1-10 alkyl,7) Cy-(Cy.sup.1).sub.p -C.sub.2-10 alkenyl,8) Cy-(Cy.sup.1).sub.p -C.sub.2-10 alkynyl,alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy and Cy.sup.1 are optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.6 is1) hydrogen,2) a group selected from R.sup.a, or3) a group selected from R.sup.1 ;R.sup.7 is1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, or6) Cy C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl are optionally substituted with one to four substitutents selected from R.sup.a, and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.a is1) --CF.sub.3 ;2) --OR.sup.d,3) --NO.sub.2,4) halogen5) --S(O).sub.m R.sup.d,6) --CR.sup.d (N--OR.sup.e),7) --S(O).sub.2 OR.sup.d,8) --S(O).sub.m NR.sup.d R.sup.e,9) --NR.sup.d R.sup.e,10) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,11) --C(O)R.sup.d,12) --CO.sub.2 R.sup.d,13) --CO.sub.2 (CR.sup.f R.sup.g).sub.n CONR.sup.d R.sup.e,14) --OC(O)R.sup.d,15) --CN,16) --C(O)NR.sup.d R.sup.e,17) --NR.sup.d C(O)R.sup.e,18) --OC(O)NR.sup.d R.sup.e,19) --NR.sup.d C(O)OR.sup.e, or20) --NR.sup.d C(O)NR.sup.d R.sup.e ;R.sup.b is1) a group selected from R.sup.a,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, or6) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl, and Cy are optionally substituted with a group independently selected from R.sup.c ;R.sup.c is1) halogen,2) amino,3) carboxy,4) C.sub.1-4 alkyl,5) C.sub.1-4 alkoxy,6) hydroxy,7) aryl,8) aryl C.sub.1-4 alkyl, or9) aryloxy;R.sup.d and R.sup.e are independently selected from the group consisting of1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, and6) Cy C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R.sup.c ; orR.sup.d and R.sup.e together with the atoms to which they are attached form a heterocyclic ring of 5 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen;R.sup.f and R.sup.g are independently selected from hydrogen, C.sub.1-10 alkyl, Cy and Cy C.sub.1-10 alkyl; orR.sup.f and R.sup.g together with the carbon to which they are attached form a ring of 5 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen;R.sup.h is1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) cyano,6) aryl,7) aryl C.sub.1-10 alkyl,8) --SO.sub.2 R.sup.i ;wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and aryl and heteroaryl are each optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.i1) C.sub.1-10 alkyl,2) C.sub.2-10 alkenyl,3) C.sub.2-10 alkynyl, or4) aryl;wherein alkyl, alkenyl, alkynyl and aryl are each optionally substituted with one to four substituents independently selected from R.sup.c ;Cy and Cy.sup.1 are independently selected1) cycloalkyl,2) aryl, andm is 0, 1 or 2;n is an integer from 1 to 10; andp is 0 or 1.