Patent ID: 7332582
Filing Date: 2008-02-19
Classification: A61K,A61P,C07K

Abstract:
1. A humanized antibody comprising the complementarity-determining regions (CDRs) of murine monoclonal antibody BAT-1 (mBAT-1), wherein the humanized antibody comprises: a light chain variable region selected from the group consisting of: BATRKA (SEQ. ID NO. 15), BATRKB (SEQ. ID NO. 16), BATRKC (SEQ. ID NO. 17), and BATRKD (SEQ. ID NO. 18), and a heavy chain variable region selected from the group consisting of: BATRHA (SEQ. ID NO. 20), BATRHB (SEQ. ID NO. 21), BATRHC (SEQ. ID NO. 22), BATRHD (SEQ. ID NO. 23) and BATRHE (SEQ. ID NO. 24); wherein the humanized antibody retains the anti-tumor activity of mBAT-1 and is less immunogenic in a human subject than mBAT-1.