Patent ID: 7799900
Filing Date: 2010-09-21
Classification: A61K,A61P,C07K

Abstract:
1. A humanized antibody that binds human CD20, the humanized antibody comprising the heavy and light chain amino acid sequences of SEQ ID NO. 39 and 40, respectively, wherein the binding affinity to human CD20 of the humanized antibody is higher than the binding affinity to human CD20 of an antibody comprising the heavy chain amino acid sequence of SEQ ID NO. 39 with sequence modifications in the variable region wherein position 49 is Ala, position 71 is Arg, and position 73 is Asn, and the light chain amino acid sequence of SEQ ID NO. 40 with a sequence modification in the variable region wherein position 46 is Leu, wherein the amino acid positions are numbered according to the numbering system of Kabat.