Patent ID: 6322550
Filing Date: 2001-11-27
Classification: A61K,A61N

Abstract:
A method for transdermal administration of a GP IIb/IIIa antagonist by iontophoresis, which comprises:conducting a first series of electric current application steps, and thenconducting a further or second series of electric current application step(s) for maintaining a pharmacologically effective GP IIb/IIIa antagonist concentration in the serum,wherein the first series comprises plural electric current application steps which are conducted continuously without interval, in which each step comprises the steps of:providing a GP IIb/IIIa antagonist to the skin, andapplying electric currents to drive the antagonist into the skin, in which the current density is progressively reduced in the subsequent application step,wherein the further or second series comprises one or more electric current application step(s) which are preceded by an interval before each application, andwherein the antagonist concentration in the serum is maintained at about 10 to 500 ng/ml within 240 minutes from the initial electric current application step in the first series of application steps.