Patent ID: 6087325
Filing Date: 2000-07-11
Classification: A61K,C07K

Abstract:
A peptide-lipid conjugate having the formula: ##STR6## wherein: X is a linker selected from the group consisting of a single bond and the group R.sup.3 ; each of R.sup.1, R.sup.2 and R.sup.3 is --OC(O)(CH.sub.2).sub.n1 (CH.dbd.CH).sub.n2 (CH.sub.2).sub.n3 (CH.dbd.CH).sub.n4 (CH.sub.2).sub.n5 (CH.dbd.CH).sub.n6 (CH.sub.2).sub.n7 (CH.dbd.CH).sub.n8 (CH.sub.2).sub.n9 CH.sub.3 ;n1 is zero or an integer equal to from 1 to 22, n3 is zero or an integer equal to from 1 to 19, n5 is zero or an integer equal to from 1 to 16, n7 is zero or an integer equal to from 1 to 13, n9 is zero or an integer equal to from 1 to 10;for each of R.sup.1 and R.sup.2 the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer equal to from 12 to 22;for R.sup.3 the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer equal to from 0 to 22,each of n2, n4, n6 and n8 is equal to 0 or 1; and,Y is an enzyme cleavable peptide comprising an amino acid sequence which is the substrate of a cell-secreted peptidase.