Patent ID: 8409589
Filing Date: 2013-04-02
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A purified mutant streptolysin O (SLO) protein comprising an amino acid alteration to the amino acid sequence of wild-type SLO selected from the group consisting of: (a) a substitution of glutamine for proline at amino acid position 427; (b) a substitution of lysine for proline at amino acid position 427; (c) a substitution of glycine for proline at amino acid position 427; (d) a substitution of leucine for proline at amino acid position 427; and (e) a substitution of phenylalanine for tryptophan at amino acid position 535, wherein the amino acid positions are numbered according to SEQ ID NO: 1.