Patent ID: 7919671
Filing Date: 2011-04-05
Classification: A01K,A61P,C12N,C12Q,G01N,Y10T

Abstract:
1. A method of screening for a compound that decreases PI(4,5)P 2 accumulation or decreases PI(3)P levels comprising: (a) administering said compound to a knockout mouse whose genome comprises a homozygous disruption in a nucleic acid encoding prostatic acid phosphatase (PAP), wherein said disruption results in the null inactivation of PAP and wherein said knockout mouse exhibits prostatic atypical hyperplasia, prostatic intraepithelial neoplasia, adenocarcinoma of the prostate, myopathy or neuropathy; and (b) determining if said administered compound decreases PI(4,5)P wherein said decreased PI(4,5)P