Patent ID: 7157422
Filing Date: 2007-01-02
Classification: A61K,C07K,C12N

Abstract:
1. A peptide inhibitor of glycogen synthase kinase-3 (GSK-3), comprising a polypeptide having between 7 and 20 amino acid residues and the amino acid sequence XZXXXS(p)X, wherein: S(p)=phosphorylated serine or threonine, X=any amino acid, whereas at least one of X is a proline residue, and Z=any amino acid except serine or threonine, said amino acid sequence being a part of the GSK-3 substrate heat shock factor-1(HSF-1) protein containing a single SXXXS(p) recognition motif, wherein S is serine and S(p) is a phosphorylated serine, in which S is replaced by said Z, with the proviso that the polypeptide does not contain two or more SXXXS motifs, wherein S=serine, upstream of the S(p) residue, said polypeptide being capableof inhibiting the enzymatic activity of GSK-3.