Patent ID: 6245901
Filing Date: 2001-06-12
Classification: A61K,C11D

Abstract:
A conjugate comprising a protease moiety conjugated to one or more polymers, wherein the protease moiety is a Bacillus sp. protease comprising one or more of the following substitutions: P6K, Y7K, S9K, A10K, Y11K, Q12E, Q12D, Q12K, R28K, Q33E, Q33D, D43K, Y44K, N45K, R51K, R62K, N65K, D68N, D68Q, G87K, I88K, D106N, D106Q, R121K, Q126D, Q126E, R169K, R19K, N209D, N209E, N209K, A211K, N216K, N217K, G218K, Y219K, S220K, Y221K, Q242D, Q242E, N245D, N245E, N246D, N246E, Q248D, Q248E, R250K, G262K, N266D and N266E.