Patent ID: 8895548
Filing Date: 2014-11-25
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating Alzheimer's disease, comprising: administering a composition in an amount effective for treating Alzheimer's disease to a subject in need thereof, wherein the composition comprises a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, wherein Alk 1 is lower alkylene or lower alkenylene; R 0 is a hydrogen atom, lower alkyl, or acyl; X is S or O; R 2a and R 2b are each independently a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted amino, optionally substituted amidino, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted carbamoylcarbonyl, optionally substituted lower alkylsulfonyl, optionally substituted arylsulfonyl, an optionally substituted carbocyclic group, or an optionally substituted heterocyclic group; R 3a , R 3b , R 4a , and R 4b are each independently a hydrogen atom, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted acyl, carboxy, optionally substituted lower alkoxycarbonyl, optionally substituted amino, optionally substituted carbamoyl, an optionally substituted carbocyclic group, or an optionally substituted heterocyclic group; n and m are each independently an integer of 0 to 3; n+m is 3; each R 3a , each R 3b , each R 4a , and each R 4b may be independently different; R 5 is a hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, an optionally substituted carbocyclic group, or an optionally substituted heterocyclic group; R 5 and ring A can be taken together to form wherein R 5a and R 5b are each independently a hydrogen atom or lower alkyl; s is an integer of 1 to 4; and each R 5a and each R 5b may be different, its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.