Patent ID: 8703967
Filing Date: 2014-04-22
Classification: A61P,C07D

Abstract:
1. A process for the preparation of crystal form comprising malic acid salt of sunitinib, the process comprising the steps of: a) mixing a compound of formula I, N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide with compound of formula II, 5-fluoroindolin-2-one in a solvent; b) refluxing the mixture obtained in step a); c) adding malic acid to a mixture subsequent to step b); and d) allowing the crystal form comprising malic acid salt of sunitinib to crystallize subsequent to step c), wherein steps a) to d) are carried out in one pot without intermediate isolation of sunitinib base formed by steps a) and b).