Patent ID: 6835726
Filing Date: 2004-12-28
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula: wherein X is a member selected from the group consisting of â€”NR3R4, â€”OR3, â€”SR3, aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, â€”NR6)â€”, â€”Oâ€”, â€”Sâ€”, â€”C(&boxH;O)â€” and alkylene; R1 and R2 are members independently selected from the group consisting of hydrogen, alkyl, â€”O-alkyl, â€”S-alkyl, aryl, arylalkyl, â€”O-aryl, â€”S-aryl, â€”NO2, â€”NR7R8, â€”C(O)R9, â€”CO2R10, â€”C(O)NR7R8, â€”N(R7)C(O)R9, â€”N(R7)CO2R11, â€”N(R9)C(O)NR7R8, â€”S(O)mNR7R8, â€”S(O)nR9, â€”CN, halogen, and â€”N(R7)S(O)mR11; R3 and R4 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl, or taken together with the nitrogen atom to which each is attached form a 5-, 6- or 7-membered aromatic or non-aromatic ring containing from one to three heteroatoms selected from the group consisting of N, O and S; R5 is a member selected from the group consisting of alkyl, aryl, arylalkyl and bicyclic fused aryl-cycloalkyl; R6 is a member selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl; or is combined with R5 and the nitrogen atom to which R5 and R6 are attached to form a 5-, 6-, 7- or 8-membered aromatic or non-aromatic ring containing one to three heteroatoms selected from the group consisting of N, O or S; R7 and R8 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl; R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl; R11 is a member selected from the group consisting of alkyl, aryl and arylalkyl; m is an integer of from 1 to 2; n is an integer of from 1 to 3; and wherein R1 and R3, R5 and N1, or R2 and N1 are joined to form a 5-, 6-, 7-, or 8- membered aromatic or non-aromatic ring containing one to three heteroatoms selected from the group consisting of N, O and S; said compound having a molecular weight of from about 150 to about 750, with the proviso that when Y is a bond, then R5 is other than an imidazole ring.