Patent ID: 6635655
Filing Date: 2003-10-21
Classification: A61P,C07C,C07D,Y10S

Abstract:
A compound of formula (I) wherein: is oxazolyl or quinolinyl, which are optionally substituted by one or more ring system substituents; is phenyl, which is optionally substituted by one or more ring system substituents, in addition to being substituted by group Z; B and E are a chemical bond; a is 1; b is 0 or 1; c is 0; d is 0; g is 1-5; R1, R2, R3 and R4 are, independently, hydrogen, halogen or alkyl, wherein alkyl is optionally substituted by one or more alkyl group substituents; Z is R21O2Câ€”, R21OCâ€”, â€”CN, R21O2SHNCOâ€”, R21O2SHNâ€”, (R21)2NCOâ€” or R21Oâ€”; R21 is independently hydrogen, alkyl, which is optionally substituted by one or more alkyl group substituents, aryl, which is optionally substituted by one or more ring system substituents, cycloalkyl, which is optionally substituted by one or more ring system substituents, or aralkyl, wherein the aryl portion is optionally substituted by one or more ring system substituents and the alkyl portion is optionally substituted by one or more alkyl group substituents; R15, R16 are independently hydrogen, alkyl, which is optionally substituted by one or more alkyl group substituents, aralkyl, wherein the aryl portion is optionally substituted by one or more ring system substituents and the alkyl portion is optionally substituted by one or more alkyl group substituents, or alkoxycarbonyl, wherein the alkyl portion is optionally substituted by one or more alkyl group substituents; or a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof,whereinalkyl is an aliphatic hydrocarbon group which is straight or branched having 1 to about 20 carbon atoms; aryl is an aromatic monocyclic or multicyclic ring system of about 6 to about 14 carbon atoms; a ring system substituent is halo, unsubstituted lower alkyl of 1 to about 4 carbon atoms, unsubstituted alkoxy, unsubstituted aryloxy, unsubstituted aralkyloxy or unsubstituted cycloalkylalkyloxy; and an alkyl group substituent is unsubstituted acyl, carboxyl, unsubstituted carboxymethyl, unsubstituted methoxycarbonylethyl, unsubstituted benzyloxycarbonylmethyl, unsubstituted pyridylmethyloxycarbonylmethyl or unsubstituted alkoxycarbonyl.