Patent ID: 6451799
Filing Date: 2002-09-17
Classification: A61K,A61P,Y10S

Abstract:
A method for ameliorating an ocular circulatory disorder caused by a circulatory disorder in the ciliary artery system selected from the group consisting of normal tension glaucoma, retinitis pigmentosa, macular degeneration, ischemic optic neuropathy and iridocyclitis, or for ameliorating an ocular circulatory disorder caused by a circulatory disorder in the central retinal artery system selected from the group consisting of retinal artery occlusion, retinal vein occlusion, diabetic retinopathy, ischemic optic neuropathy, retinal disease following retinal lesion and choroidal disease accompanied by systemic disease,comprising administering a 1,4-dihydropyridine derivative of the formula (I): â€ƒwherein X1 and X2 are the same or different and each is hydrogen atom or nitro; R1 is lower alkyl; R2 is alkenyl; A is alkylene having a carbon atom bonded with two alkyl and having a total number of carbon atoms of 5 to 10; and m is 2, or an acid addition salt thereof, in an amount effective for ameliorating the ocular circulation disorder, to a local site in the eye.