Patent ID: 6184388
Filing Date: 2001-02-06
Classification: C07D

Abstract:
A compound represented by the formula (XV), a free acid thereof, a salt of the free acid, a hydrate of the free acid, or a hydrate of a salt of the free acid: ##STR136##whereinR.sup.111 represents a protective group for an amino group; andprovided that the substituent R.sup.4 and the substituent containing the cyclic structure bonded to the carbon atom adjacent to the carbon atom to which the substituent R.sup.4 is bonded are positioned in the cis-configuration,R.sup.2 represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms which may be substituted with one or more substituents selected from the group consisting of a halogen group, a hydroxyl group, an alkylthio group having 1 to 6 carbon atoms and an alkoxyl group having 1 to 6 carbon atoms;R.sup.3 and R.sup.5 each represent a hydrogen atom, wherein the hydrogen atoms are positioned in the cis-configuration with respect to the pyrrolidine ring;R.sup.4 represents a halogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxyl group having 1 to 6 carbon atoms or an alkylthio group having 1 to 6 carbon atoms,wherein the alkyl group may have one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, and an alkoxyl group having 1 to 6 carbon atoms;R.sup.6 and R.sup.7 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms which is selected from the group consisting of methyl, ethyl, n-propyl and isopropyl; andn represents an integer of from 1 to 3.