Patent ID: 6498015
Filing Date: 2002-12-24
Classification: A01K,A61K,C07K

Abstract:
A method for identifying a chemical compound having Macrophage Derived Chemokine (MDC) modulating activity comprising the steps of:(a) providing first and second receptor compositions comprising chemokine receptor CCR4; (b) providing a control composition comprising detectably-labeled MDC; (c) providing a test composition comprising detectably-labeled MDC and further comprising said chemical compound; (d) contacting the first receptor composition with the control composition under conditions wherein MDC is capable of binding to CCR4; (e) contacting the second receptor composition with the test composition under conditions wherein MDC is capable of binding to CCR4; (f) washing the first and second receptor compositions to remove detectably-labeled MDC that is unbound to CCR4; (g) measuring detectably-labeled MDC in said first and second receptor compositions; and (h) identifying a chemical compound having MDC modulating activity, wherein MDC modulating activity is correlated with a difference in detectably-labeled MDC between said first and said second receptor compositions.