Patent ID: 6747058
Filing Date: 2004-06-08
Classification: A61K

Abstract:
A stable, aerosolizable composition, the composition consisting essentially of a therapeutically effective amount of delta-9-tetrahydrocannabinol in a pharmaceutically-acceptable semiaqueous solvent comprising volumetric ratios of about 10-70 parts of ethanol, about 10-30 parts of water and about 30-80 parts of propylene glycol having a combined total of 100, provided that:(i) upon aerosolization the composition has a mean mass median aerodynamic diameter in the range from about 1 up to about 10 &mgr;M; (ii) the ratio of the ethanol, water and propylene glycol produces a stable clear solution near the solubility point of the delta-9-tetrahydrocannabinol such that upon administration to the lung, the partitioning of the delta-9-tetrahydrocannabinol from the solvent is enhanced so as to reach the bloodstream; and (iii) the composition is pharmaceutically suitable for rapid bronchial delivery to the lung of a subject.