Patent ID: 8999954
Filing Date: 2015-04-07
Classification: A61K,A61P

Abstract:
1. A method of inhibiting growth of a cancerous cell in a subject, said method comprising: administering to the subject a pharmaceutical composition comprising an effective amount of an inhibitor of a polysialic acid (PSA) de-N-acetylase in a pharmaceutically acceptable vehicle, wherein the inhibitor is a monomer of an N-substituted derivative of a hexosamine compound of formula (I): or the pharmaceutically acceptable salts, solvate, prodrug, anomers, tautomers and stereoisomers forms thereof; wherein R each R with the proviso that said inhibitor of PSA de-N-acetylase is other than N-acryl glucosamine; an unacetylated or tetra-O-acetylated N-haloacetyl mannosamine; an unacetylated or tetra-O-acetylated N-haloacetyl galactosamine; and an unacetylated or tetra-O-acetylated N-haloacetyl glucosamine; and wherein said administering facilitates reduction in viability of cancerous cells exposed to said inhibitor.