Patent ID: 8859529
Filing Date: 2014-10-14
Classification: A61P,C07D

Abstract:
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein: ring A is selected from the group consisting of aryl and heteroaryl, each of which is substituted with —Y—R Q is—O—; X is selected from the group consisting of —S—, —O—, —S(O) T is absent or present, and if present, T is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, and heteroaryl, wherein when each of said T cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a second five- or six-membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl or heteroaryl ring, wherein when each of said optional second five- or six-membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl or heteroaryl further contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a further third five- or six-membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl or heteroaryl ring wherein each of the aforementioned T aryl, and heteroaryl, optionally with said first and/or second five- to six-membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl or heteroaryl is independently unsubstituted or substituted with one to four R U is absent or present or absent, and if present, U is selected from the group consisting of —N(R V is absent or present, and if present V is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, and heteroaryl, wherein when each of said V cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- or six-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring; wherein each of said V alkyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl heterocyclyl, optionally with said five- or six-membered cycloalkyl, aryl, heterocyclyl, or heteroaryl is independently unsubstituted or substituted with one to four R Y is selected from the group consisting of a covalent bond, —(C(R Z is selected from the group consisting of a covalent bond, —(C(R n is 1 p is 1 to 3; q is 1 to 3; each R independently is selected from the group consisting of H, alkyl, and aryl; R′ is selected from the group consisting of H, alkyl, and aryl; R R R each R R each R each R R or wherein two R each R R or when two R R or when two R with the proviso that at least one of T, U, and V must be present.