Patent ID: 8332159
Filing Date: 2012-12-11
Classification: A61K,A61P,C07K

Abstract:
1. A method for enhancing the efficacy of a monoclonal antibody preparation, wherein said monoclonal antibody is an antibody recognizing the V3 region of the envelope glycoprotein gp120 of human immunodeficiency virus type1 (HIV-1), the method comprising: a. isolating a nucleotide sequence of a gene of a target molecule from a patient and deducing the amino acid sequence encoded by the nucleotide sequence; b. comparing the deduced amino acid sequence with a reference amino acid sequence having a specific epitope recognized by a monoclonal antibody comprised by said monoclonal antibody preparation to determine if the deduced amino acid sequence shares the specific epitope with the reference amino acid sequence to determine if the monoclonal antibody will recognize the deduced amino acid sequence; and c. administering the monoclonal antibody preparation to patients in which the deduced amino acid sequence shares a specific epitope with the reference amino acid sequence so that the monoclonal antibody can recognize the deduced amino acid sequence.