Patent ID: 8951518
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. A preventive and/or therapeutic method for insulin dependent diabetes mellitus, comprising administering an effective amount of a bispecific antibody to an insulin dependent diabetes mellitus patient, wherein the bispecific antibody comprises the following parts; (a) VH region of anti-human PD-1 antibody; (b) VL region of anti-human CD3 antibody; (c) VH region of said anti-human CD3 antibody; and (d) VL region of said anti-human PD-1 antibody, and wherein each of said part is linked by peptide linkers, so that said part (a) can bind to human PD-1 together with said part (d) and said part (c) can bind to human CD3 together with said part (b).