Patent ID: 6720316
Filing Date: 2004-04-13
Classification: A61P,C07D

Abstract:
A compound of Formula (I): wherein Z is â€”Oâ€” or â€”Sâ€”; l is 1 or 2; m is 0, 1 or 2; n is 1; R1 and R2 are each independently hydrogen, C1-6alkyl, C3-6cycloalkyl, or (C3-6cycloalkyl)C1-6alkyl; provided that R1 and R2 are not both hydrogen; R3 is hydrogen or C1-6alkyl; R4 and R5 are independently hydrogen, C1-6alkyl or arylC1-6alkylene; R6, R7, and R8 are independently hydrogen, fluoro, chloro, bromo, CF3, â€”OCF3, â€”N(R10)2, C1-6alkyl, C1-6alkoxy, heteroaryl or aryl; each R10 is independently hydrogen, or â€”C1-6alkyl; wherein any C1-6alkyl, C1-6alkylene, or C1-6alkoxy of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is optionally partially unsaturated; wherein any heteroaryl or aryl is optionally substituted with one or two substituents independently selected from halo, â€”CF3, â€”OCF3, C1-6alkoxy, â€”N(R10)2, and C1-6alkyl; or a pharmaceutically acceptable salt thereof.