Patent ID: 7148003
Filing Date: 2006-12-12
Classification: A61K,C12N,C12Y

Abstract:
1. A method for determining whether a composition inhibits the peptidyl-prolyl isomerase activity of a Pin1 protein having the amino acid sequence set forth in SEQ ID NO: 2, said method comprising: incubating the composition with a Pin1 protein having the amino acid sequence set forth in SEQ ID NO: 2 or a functional fragment thereof, or with a recombinant cell expressing the Pin1 protein or a functional fragment thereof, under conditions sufficient to allow the composition to interact with the Pin1 protein or functional fragment thereof; wherein the functional fragment of the Pin1 protein has peptidyl prolyl isomerase activity; and determining the effect of the composition on the peptidyl-prolyl isomerase activity of the Pin1 protein.