Patent ID: 8546337
Filing Date: 2013-10-01
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A self-assembling peptide nanoparticle consisting of aggregates of a multitude of building blocks of formula (I) consisting of a continuous chain comprising a peptidic oligomerization domain D1, a linker segment L, and a peptidic oligomerization domain D2 wherein D1 is a peptide having a tendency to form oligomers (D1) m of m subunits D1, D2 is a peptide having a tendency to form oligomers (D2) n of n subunits D2, m and n each is a figure between 2 and 10, with the proviso that m is not equal n and not a multiple of n, and n is not a multiple of m, L is a bond or a short linker segment consisting of 1 to 6 amino acids, either D1 or D2 or both D1 and D2 is a coiled-coil oligomerization domain that incorporates one or more T- and/or B-cell epitopes within the oligomerization domain, wherein at least one of the epitopes is a helper T lymphocyte epitope (HTL epitope), and wherein D1 and/or D2 are unsubstituted or further substituted at the free end of the oligomerization domain D1 and/or D2.