Patent ID: 7485303
Filing Date: 2009-02-03
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A pharmaceutical composition comprising polyclonal F(ab′) 2 antibody fragments substantially free from albumin and whole antibodies and substantially free of pyrogens, wherein said composition binds and neutralizes a purified antigenic molecule or mixture of antigenic molecules found in the venom of a scorpion of the species Centruroides limpidus, and wherein the F(ab′) 2 antibody fragments are obtained by the method which comprises: (a) contacting a source of antibody with pepsin under conditions to prepare an antibody digest containing F(ab′) (b) treating said antibody digest by two steps of ammonium sulfate precipitation, i) one step at about 16% to about 22% weight by volume ammonium sulfate; and ii) another step at about 32% to about 38% weight by volume of ammonium sulfate.