Patent ID: 6939866
Filing Date: 2005-09-06
Classification: A61P,C07D

Abstract:
1. A quinazoline derivative of the Formula I wherein m is 0, 1, 2 or 3; each R wherein X 1 is a direct bond or is selected from O, S, SO, SO 2 , N(R 4 ), CO, CH(OR 4 ), CON(R 4 ), N(R 4 )CO, SO 2 N(R 4 ), N(R 4 )SO 2 , OC(R 4 ) 2 , SC(R 4 ) 2 and N(R 4 )C(R 4 ) 2 , wherein R 4 is hydrogen or (1-6C)alkyl, and Q 1 is aryl, aryl-(1-6C)alkyl, (3-7C)cycloalkyl, (3-7C)cycloalkyl-(1-6C)alkyl, (3-7C)cycloalkenyl, (3-7C)cycloalkenyl-(1-6C)alkyl heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, or (R 1 ) m is (1-3C)alkylenedioxy, and wherein adjacent carbon atoms in any (2-6C)alkylene chain within a R and wherein any CH wherein X 2 is a direct bond or is selected from CO and N(R 6 )CO, wherein R 6 is hydrogen or (1-6C)alkyl, and Q 2 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(16C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, and wherein any CH wherein X 3 is a direct bond or is selected from O, S, SO, SO 2 , N(R 7 ), CO, CH(OR 7 ), CON(R 7 ), N(R 7 )CO, SO 2 N(R 7 ), N(R 7 )SO 2 , C(R 7 ) 2 O, C(R 7 ) 2 S and N(R 7 )C(R 7 ) 2 , wherein R 7 is hydrogen or (1-6C)alkyl, and Q 3 is aryl, aryl-(1-6C)alkyl, (3-7C)cycloalkyl, (3-7C)cycloalkyl-(1-6C)alkyl, (3-7C)cycloalkenyl, (3-7C)cycloalkenyl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, and wherein any aryl, heteroaryl or heterocyclyl group within a substituent on R wherein X 4 is a direct bond or is selected from O and N(R 9 ), wherein R 9 is hydrogen or (1-6C)alkyl, and R 8 is halogeno-(1-6C)alkyl, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(1-6C)alkyl, (2-6C)alkanoylamino-(1-6C)alkyl or (1-6C)alkoxycarbonylamino-(1-6C)alkyl, or from a group of the formula: wherein X 5 is a direct bond or is selected from O, N(R 10 ) and CO, wherein R 10 is hydrogen or (1-6C)alkyl, and Q 4 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl which optionally bears 1 or 2 substituents, which may be the same or different, selected from halogeno, (1-6C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl and (1-6C)alkoxy, and wherein any heterocyclyl group within a substituent on R R n is 0, 1, 2 or 3; and R wherein X 6 is a direct bond or is selected from O and N(R 12 ), wherein R 12 is hydrogen or (1-6C)alkyl, and R 11 is halogeno-(1-6C)alkyl, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl or di-[(1-6C)alkyl]amino-(1-6C)alkyl, or from a group of the formula: wherein X 7 is a direct bond or is selected from O, S, SO, SO 2 , N(R 13 ), CO, CH(OR 13 ), CON(R 13 ), N(R 13 )CO, SO 2 N(R 13 ), N(R 13 )SO 2 , C(R 13 ) 2 O, C(R 13 ) 2 S and N(R 13 )C(R 13 ) 2 , wherein R 13 is hydrogen or (1-6C)alkyl, and Q 5 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl which optionally bears 1 or 2 substituents, which may be the same or different, selected from halogeno, (1-6C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl and (1-6C)alkoxy, and any heterocyclyl group within Q 5 optionally bears 1 or 2 oxo or thioxo substituents, or a pharmaceutically acceptable salt thereof.