Patent ID: 9107983
Filing Date: 2015-08-18
Classification: A61L,A61P

Abstract:
1. An implantable osteoconductive matrix configured to fit at or near a target tissue site, the matrix being malleable and cohesive and comprising a biodegradable polymer and a therapeutically effective amount of a statin disposed within the interior of the matrix, the matrix having a load of the statin between about 20 mg and 500 mg, wherein the matrix allows influx of at least progenitor, and/or bone cells therein, and the matrix comprises ceramic and collagen, the ceramic having a density of about 0.15 g/cc to about 0.45 g/cc of the matrix and the collagen having a density of about 0.02 g/cc to about 1.0 g/cc of the matrix and the matrix comprises mineral particles having a porosity of 5% to 25% dispersed therein having an average particle diameter in the range of 0.1 mm to 2 mm, and the mineral particles overlap each other by at least 75%, and the matrix comprises polyethylene glycol (PEG), magnesium, an antioxidant and trehalose, and wherein the matrix resist compression by at least 85% when force is applied to the matrix.