Patent ID: 7081249
Filing Date: 2006-07-25
Classification: A61K,A61P

Abstract:
1. A method of treating with oxybutynin a human subject having overactive bladder, while minimizing an anticholinergic or antimuscarinic adverse drug experience associated with said oxybutynin treatment therapy comprising the step of: administering as a transdermal patch, a composition comprising oxybutynin to said subject to provide a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of from about 0.5:1 to about 5:1 with a peak oxybutynin metabolite plasma concentration of less than about 8 ng/ml, wherein the metabolite of oxybutynin is N-desethyloxybutynin, and wherein the transdermal patch optionally includes a permeation enhancer.