Patent ID: 6869929
Filing Date: 2005-03-22
Classification: A61K,G01N

Abstract:
1. A method of screening compounds that are capable of reducing inflammation comprising: (a) providing cells which do not normally express a measurable amount of a transcription factor except in the presence of a pro-inflammatory agent; (b) providing two portions of said cells to form a control and exoerimental group of cells; c) providing the experimental group of cells with said compound; (d) providing the pro-inflammatory agent to both the control and experimental group of cells; (e) measuring the expression of the transcription factor in both the control and the experimental group of cells; and (f) comparing the amount of expression of said transcription factor in the experimental group of cells with the control group of cells, wherein decreased expression of said transcription factor in the experimental group of cells when compared to the control group of cells indicates that the compound may be capable of reducing inflammation in vivo.