Patent ID: 8357517
Filing Date: 2013-01-22
Classification: C12Q

Abstract:
1. A method of assessing if a subject is at high risk of developing asthma, comprising: a) analyzing nucleic acid derived from said subject by performing a biological assay to determine whether the following polymorphic forms of the TLR7, CCL11, and CCL2 genes of said subject are present: b) correlating the frequency of combinations of said polymorphic forms with the likelihood said subject is at high risk of developing asthma wherein combinations comprising rs17735961 (SEQ ID NO: 11), rs 179019 (SEQ ID NO: 7), rs1129844 (SEQ ID NO:10) and rs 179020 (SEQ ID NO: 8) have a direct effect on asthma status and combinations comprising rs4795895 (SEQ ID NO: 12), rs179017 (SEQ ID NO: 9) and rs4586 (SEQ ID NO: 13) have an indirect effect on asthma through association with the other polymorphic forms.