Patent ID: 6579882
Filing Date: 2003-06-17
Classification: C07D

Abstract:
A compound having Formula I or a pharmaceutically acceptable salt thereof, whereE and G are independently selected from (1) nitrogen and (2) N+â€”Oâˆ’; F is carbon; Z is S(O)t where t is an integer 0-2; Y is carbon; LA is â€”S(O)t; XA is selected from (1) halo, (2) alkyl of one to ten carbons optionally substituted with 1, 2, or 3 substituents independently selected from (a) oxo, (b) cycloalkyl of three to ten carbons, (c) â€”CO2R7 where R7 is selected from (i) hydrogen and (ii) alkyl of one to ten carbons optionally substituted with 1, or aryl and cycloalkyl of three to ten carbons, (d) â€”NR8R9 where R8 and R9 are independently selected from (i) hydrogen, (ii) alkyl of one to six carbons optionally substituted with 1 or 2 substituents independently selected from â€”OH, aryl, heterocycle, cycloalkyl of three to ten carbons, and â€”NRARB where RA and RB are independently selected from hydrogen and alkyl of one to six carbons optionally substituted with 1 or 2 substituents selected from â€”OH, (iii) alkanoyl where the alkyl part is of one to to ten carbons, (iv) cycloalkyl of three to ten carbons, (v) alkoxy, (vi) heterocycle, and (vii) aryl, â€ƒwhere (vi) and (vii) are substituted with 1 or 2 substituents independently selected from alkyl of one to six carbons and halo, (e) â€”C(W)R10 where W is O or R10 is selected from (i) hydrogen, (ii) alkyl of one to ten carbons optionally substituted with 1, or 2 substituents independently selected from aryl and cycloalkyl of three to ten carbons, (iii) â€”NR8R9, and (iv) â€”OR7, (f) â€”OH, (g) aryl, and (h) heterocycle, â€ƒwhere (g) and (h) can be optionally substituted with 1,2,3,4, or 5 substituents independently selected from (i) alkyl of one to twenty carbons, (ii) â€”NR8R9, (iii) alkoxy of one to ten carbons, (iv) thioalkoxy of one to ten carbons, (v) halo, (vi) perfluoroalkyl of one to three carbons, (vii) alkenyl of two to ten carbons, (viii) alkyl of one to ten carbons optionally substituted with 1 or 2 substituents independently selected from alkoxy of one to ten carbons and â€”OH, (ix) â€”CO2R7, (x) aryl, and (xi) â€”CHO, (3) cycloalkyl of three to ten carbons, (4) aryl, (5) heterocycle where (4) and (5) can be optionally substituted with 1,2,3,4, or 5 substituents independently selected from(a) alkyl of one to twenty carbons, (b) alkyl of one to ten carbons substituted with 1,2, or 3 substituents independently selected from (i) â€”OR11 where R11 is selected from hydrogen, â€”C(W)R12 where R12 is selected from alkyl of one to ten carbons, cycloalkyl of three to ten carbons, aryl, and heterocycle, and â€ƒheterocycle optionally substituted with 1,2,3, or 4 substituents independently selected from â€”OH and alkyl of one to six carbons optionally substituted with 1 or 2 substituents selected from â€”OH, (ii) alkoxy of one to ten carbons optionally substituted with 1 or 2 substituents independently selected from alkoxy and alkoxyalkoxy, (iii) spiroalkyl of three to ten carbons, and (iv) halo, (c) alkoxy of one to ten carbons optionally substituted with 1 or 2 substituents independently selected from (i) alkoxy and (ii) alkoxyalkoxy, (d) thioalkoxy of one to ten carbons, (e) halo, (f) perfluoroalkyl of one to three carbons, (g) alkenyl of two to ten carbons optionally substituted with 1 or 2 substituents independently selected from (i) â€”C(W)R10 and (ii) â€”C(W)R12, (h) â€”CO2R7, (i) â€”NR8R9, (j) aryl, (k) â€”C(W)R12, (l) â€”CHO, (m) â€”C(O)NR8R9, (n) â€”CN, (o) heterocycle optionally substituted with 1 or 2 substituents independently selected from (i) alkyl of one to ten carbons and (ii) perfluoroalkyl of one to three carbons, (p) â€”C(W)R10, (q) ethylenedioxy, and (r) â€”OCF3, (6) â€”OR7, (7) hydrogen, and (8) â€”NR8R9; LB is selected from(1) a covalent bond, (2) â€”Oâ€”, (3) â€”S(O)tâ€”, (4) â€”NR6â€”, (5) â€”C(W)â€”, and (6) â€”C(&boxH;NR13)â€” where R13 is selected from (a) hydrogen, (b) â€”NO2, (c) â€”CN, and (d) â€”OR14 where R14 is selected from (i) hydrogen, (ii) aryl, and (iii) alkyl of one to ten carbons optionally substituted with 1 or 2 substituents independently selected from aryl and â€”C(O)R15 where R15 is selected from hydrogen, â€”OH, alkoxy, and NRARB; XB is alkyl of one to ten carbons optionally substituted with 1, 2 or 3 substituents independently selected from(a) â€”CO2R7, (b) â€”NR8R9, (c) â€”C(W)NR8R9, (d) heterocycle, (e) aryl optionally substituted with 1 or 2 substituents independently selected from (i) alkyl of one to ten carbons, (ii) â€”NO2, and (iii) â€”NRARB, (f) â€”OR16 where R16 is selected from (i) hydrogen and (ii) â€”C(W)NRARB, and (g) â€”NRAC(W)NR8R9, R1, R3, and R5 are absent and R2 and R4 are independently selected from(1) hydrogen (2) alkyl of one to six carbons optionally substituted with 1 or 2 substituents independently selected from (a) â€”OC(O)R22, where R22 is selected from (i) alkyl, (ii) alkoxy, and (iii) NRARB, (b) alkoxy, (c) â€”OH, (d) â€”NRARB, (e) heterocycle, and (f) aryl, (3) â€”CO2R7, (4) â€”C(O)NRARB, (5) â€”SR23 where R23 is selected from (a) hydrogen, (b) alkyl of one to six carbons, (c) aryl optionally substituted with 1 or 2 substituents selected from (i) alkyl of one to six carbons and (ii) halo, (6) NRARB, (7) alkoxy, (8) perfluoroalkyl of one to three carbons, (9) â€”OH, and (10) heterocycle.