Patent ID: 8007795
Filing Date: 2011-08-30
Classification: A61K,A61P,C07K

Abstract:
1. An anti-TF antibody comprising a light chain, wherein the light chain comprises: (a) CDR1 having the sequence of LASQTIDTWLA (SEQ ID NO: 116), (b) CDR2 having the sequence of AATNLAD (SEQ ID NO: 6), (c) CDR3 having the sequence of QQVYSSPFT (SEQ ID NO:7), (d) a first framework (FR1) comprising a sequence having at least 95% identity to SEQ ID NO:109, (e) a second framework (FR2) comprising a sequence having at least 95% identity to SEQ ID NO: 108; (f) a third framework (FR3) comprising a sequence having at least 95% identity to SEQ ID NO: 112, and (g) a fourth framework (FR4) comprising a sequence having at least 95% identity to a sequence selected from the group consisting of: SEQ ID SEQ ID NO: 110 and further comprising a heavy chain, wherein the heavy chain comprises: (h) CDR1 having the sequence of DYNVY (SEQ ID NO: 134), (i) CDR2 having the sequence of YIDPYNGITIYDQNFKG (SEQ ID NO: 9) or CDR2 having the sequence of YIDPYNGITIYDQNLKG (SEQ ID NO: 101), (j) CDR3 having the sequence of DVTTALDF (SEQ ID NO:10), (k) a first framework (FR1) comprising a sequence having at least 95% identity to SEQ ID NO: 129; (l) a second framework (FR2) comprising a sequence having at least 95% identity to SEQ ID NO: 123; (m) a third framework (FR3) comprising a sequence having at least 95% identity to SEQ ID NO: 126; and (n) a fourth framework (FR4) comprising a sequence having at least 95% identity to SEQ ID NO: 122.