Patent ID: 7018806
Filing Date: 2006-03-28
Classification: C12Q,G01N

Abstract:
1. A kit for screening for an endocrine disruptor comprising a granulosa-like tumor cell line having aromatase activity, and components for assaying for inhibition or activation of aromatase activity, wherein said cell line has the following characteristics: (a) Origin: female invasive ovarian granulosa cell carcinoma; (b) Doubling time: 46.4 h; (c) Abnormal karyotype: 45, XX, 7q-, -22 (7q deletion and monosomy 22); (d) Possesses aromatase activity; (e) Produces progesterone upon exposure to human chorionic gonadotropin (HCG); and (f) Expresses follicle stimulating hormone receptor (FSH receptor).