Patent ID: 9067964
Filing Date: 2015-06-30
Classification: A61K,C07H

Abstract:
1. A complex for facilitating transmembrane transport of a molecular cargo into the nucleus of a mammalian cell, wherein said complex comprises a molecular cargo coupled to a synthetic m 3 G-CAP or an analogue thereof, wherein said molecular cargo is linked by covalent or non-covalent attachment to at least one modified 2,2,7-trimethylguanosine CAP structure as specified in Formula (I) wherein R R R R R R X is OH or SH, or salts thereof; Y is OH or SH, or salts thereof; Z is OH or SH, or salts thereof; R R R R R wherein “base” is a purine or a pyrimidine base selected from uracil, cytosine, adenine, quinine or thymine or derivatives thereof.