Patent ID: 7115723
Filing Date: 2006-10-03
Classification: A61P,C07K

Abstract:
1. A gene encoding a humanized heavy chain which comprises a humanized heavy chain variable region having an amino acid sequence selected from the group consisting of: the amino acid sequence of SEQ ID NO: 21; and the amino acid sequence of SEQ ID NO: 21 which is modified by at least one amino acid substitution selected from the group comprising: Lys 12 →Val 12 , Thr 28 →Ala 28 , Thr 30 →Ser 30 , Met 48 →Ile 48 , Arg 67 →Lys 67 , Val 68 →Ala 68 , Met 70 →Leu 70 , Val 79 →Ala 79 , and Tyr 95 →Phe 95 .