Patent ID: 8017615
Filing Date: 2011-09-13
Classification: A61P,C07B,C07D,Y10T

Abstract:
1. A process for preparing a pharmaceutical solid oral preparation comprising wet granulating Anhydrous Aripiprazole Crystals B with one or more pharmaceutically acceptable carriers, obtaining granules of Anhydrous Aripiprazole Crystals B, drying the obtained granules at 70 to 100° C., shaping the obtained granules, and then drying the shaped granules at 70 to 100° C. for 1 to 6 hours again to obtain a pharmaceutical solid oral preparation wherein said Anhydrous Aripiprazole Crystals B have low hygroscopicity, wherein said low hygroscopicity is a moisture content of 0.40% or less after placing said Crystals for 24 hours in a desiccator maintained at a temperature of 60° C. and a humidity level of 100%; have a powder x-ray diffraction spectrum having characteristic peaks at 2θ=11.0°, 16.6°, 19.3°, 20.3°, and 22.1°; have particular infrared absorption bands at 2945, 2812, 1678, 1627, 1448, 1377, 1173, 960, and 779 cm exhibit an endothermic peak near about 141.5° C. in thermogravimetric/differential thermal analysis (heating rate 5° C./min); exhibit an endothermic peak near about 140.7° C. in differential scanning calorimetry (heating rate 5° C./min); and have a mean particle size of 50 μm or less.