Patent ID: 6087369
Filing Date: 2000-07-11
Classification: A61P,C07D

Abstract:
An indole derivative represented by the formula (I): ##STR42## wherein R.sup.1 represents C.sub.1 -C.sub.5 alkyl, C.sub.4 -C.sub.6 cycloalkylalkl, C.sub.5 -C.sub.7 cycloalkenylalkyl, C.sub.1 -C.sub.3 aralkyl, C.sub.4 -C.sub.5 trans-alkenyl, allyl, C.sub.1 -C.sub.3 furan-2-ylalkyl or C.sub.1 -C.sub.3 thiophene-2-ylalkyl;R.sup.2 represents hydrogen, hydroxy, C.sub.1 -C.sub.5 alkanoyloxy or C.sub.1 -C.sub.5 alkoxy;R.sup.3 represents hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkanoyl or benzyl;R.sup.4 represents hydrogen, C.sub.1 -C.sub.5 alkyl or benzyl;R.sup.5 and R.sup.6 cooperatively represent --S.dbd.T--U.dbd.V wherein one of S, T, U and V represents a nitrogen and the remainders represent CH with the proviso that the hydrogen may be substituted with R.sup.10 wherein R.sup.10 represents C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoyl, C.sub.1 -C.sub.5 hydroxyalkyl, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7 (CH.sub.2).sub.m CO.sub.2 R.sup.7, SO.sub.2 NR.sup.8 R.sup.9, CONR.sup.8 R.sup.9, or (CH.sub.2).sub.n NR.sup.8 R.sup.9 wherein m represents an integer of 0-3, n represents an integer of 1-3, R.sup.7 represents C.sub.1 -C.sub.5 alkyl, R.sup.8 and R.sup.9 ' the same or different, represent C.sub.1 -C.sub.5 alkyl, or C.sub.4 -C.sub.6 cycloalkylalkyl, and which R.sup.5 and R.sup.6 are bonded to carbon atoms adjacent to each other on the benzene ring to form a ring;and pharmaceutically acceptable acid addition salts thereof.