Patent ID: 6031112
Filing Date: 2000-02-29
Classification: A61K,A61P,C07K

Abstract:
Process for the production of alkoxycarbonyldipeptides of general formula ##STR4## wherein R represents a C.sub.1 -C.sub.6 alkyl group, saturated or unsaturated, benzyl group or trichloroethyl group which comprises:a) protecting both amino functions of L-lysine by treatment of L-lysine in aqueous alkaline medium with an alkylchloroformate of general formulaR--O--COCl IIwherein R has the above stated meaning;b) reacting the product of general formula ##STR5## obtained in step a) in an inert solvent with thionyl chloride in presence of N,N-dimethylformamide;c) reacting the N-carboxyanhydride of the N6-(alkoxycarbonyl)-L-lysine of general formula ##STR6## obtained in step b) with L-proline in hydroacetonic alkaline medium.