Patent ID: 6448273
Filing Date: 2002-09-10
Classification: C07D

Abstract:
A compound of formula I whereinR is selected from the group consisting of hydrogen, C1-6 alkyl, C7-10 aralkyl, â€”C(O)â€”R8 and the equivalent sulphonyl acid ester, wherein R8 is selected from the group consisting of C1-6 alkyl and C7-10 aralkyl, R1 is selected from the group consisting of an aliphatic hydrocarbon group and an aliphatic hydrocarbon group substituted by a hydroxy group or a carboxylic acid ester, sulpho acid ester or a C1-6 alkoxy, C6-aryloxy or C7-10aralkoxy ether thereof, and R3 is selected from the group consisting of hydrogen and C1-6 alkyl; R2 is â€”CR6R6OR7; R4 is selected from the group consisting of hydrogen, C1-6 alkyl, â€”CR6R6OR7, â€”CONHâ€”R5, â€”CONHCOR5 and â€”CON(CnH2n+1)2, R5 is selected from the group consisting of hydrogen and optionally hydroxy, alkoxy, aryloxy or aralkoxy substituted C1-13 alkyl, and C7-13 aralkyl, R6 is independently selected from the group consisting of hydrogen and C1-13 alkyl, R7 is selected from the group consisting of hydrogen, C1-13 alkyl, and C7-13 aralkyl and CnH2n+1 is C1-6 alkyl; or a pharmaceutically acceptable salt of any such compound; with the proviso that the compound is not one of 1-ethyl-2-(1â€²-hydroxyethyl)-3-hydroxypyridin-4-one, 1-methyl-2-hydroxymethyl-3-hydroxypyridoin-4-one and 1-methyl-2-hydroxymethyl-3-hydroxy-6-methylpyridin-4-one.