Patent ID: 6153736
Filing Date: 2000-11-28
Classification: A61P,C07H

Abstract:
An etherlipid having the formula: ##STR5## wherein: R.sup.1 is a group having the formula --Y.sup.1 Y.sup.2 ;Y.sup.1 is a group having the formula --(CH.sub.2).sub.n1 (CH.dbd.CH).sub.n2 (CH.sub.2).sub.n3 (CH.dbd.CH).sub.n4 (CH.sub.2).sub.n5 (CH.dbd.CH).sub.n6 (CH.sub.2).sub.n7 (CH.dbd.CH).sub.n8 (CH.sub.2).sub.n9 and the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer of from 3 to 23, n1 is equal to zero or an integer of from 1 to 23, n3 is equal to zero or an integer of from 1 to 20, n5 is equal to zero or an integer of from 1 to 17, n7 is equal to zero or an integer of from 1 to 14, n9 is equal to zero or an integer of from 1 to 11, and each of n2, n4, n6 and 8 is independently zero or 1;Y.sup.2 is CH.sub.3, CO.sub.2 H or OH;R.sup.2 is O, S, NH, --OC(O)-- or --NHC(O);R.sup.3 is a group having the formula ##STR6## wherein: X.sup.1 is Q or S;each of X.sup.2 and X.sup.3 is H, OH, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2, OCH.sub.3, NHCOCH.sub.3, F or Cl;each of X.sup.4 and X.sup.5 is H, OH, OPO.sub.3.sup.3-, OSO.sub.3.sup.2-, NH.sub.2, NHCH.sub.3 or N(CH.sub.3).sub.2 ;each of X.sup.6 and X.sup.7 is H, OH, --OX.sup.9, OPO.sub.3.sup.3- or OSO.sub.3.sup.2- ;X.sup.8 is CH.sub.2 OH when the sugar is unmodified at the C-6 position, or a group having the formula COOX.sup.10, when the sugar is modified at this position;X.sup.9 is a tetrose, pentose, hexose or heptose sugar;X.sup.10 is H, CH.sub.3 or a group having the formula Y.sup.1 Y.sup.2 : and,wherein no more than two of X.sup.2, X.sup.3, X.sup.4, X.sup.5, X.sup.6 and X.sup.7 are OH and at least one of X.sup.2, X.sup.3, X.sup.4 and X.sup.5 is a moiety comprising NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 and NHCOCH.sub.3.