Patent ID: 8961769
Filing Date: 2015-02-24
Classification: B01D,C12N

Abstract:
1. A method for process parameter control of a liquid composition in a bioreactor or live fermentation process by extracting inhibitors like organic acid ions to improve productivity and longevity of cell growth and/or to regulate metabolite production comprising at least one step of passing said liquid through a first Reverse Electro-Enhanced Dialysis (REED) membrane stack and a second REED membrane stack, each stack having: i) at least two ion-exchange membranes defining a first chamber for a first liquid there between; ii) at least two further chambers for a second liquid, each further chamber being located adjacent to the at least one first chamber; iii) a set of end membranes; iv) means for applying an electric field over each membrane stack by means of at least two electrodes; v) means for reversing the direction of the electric field within said membrane stacks; wherein within one stack, all membranes separating two chambers are of a first ionic type, wherein said end membranes are of an ionic type identical to or different from said first ionic type, and wherein the direction of the electric field within said first membrane stack is reversed at asynchronical intervals of time relative to the reversal of the electric field within said second membrane stack, and wherein said REED membrane stacks are operated in parallel.