Patent ID: 6297235
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound represented by formula IIB, or a salt thereof: ##STR15##wherein:R.sup.1 represents a five-membered heteroaromatic ring selected from oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; orR.sup.1 represents a six-membered heteroaromatic ring selected from pyrazine, pyrimidine and pyridazine;wherein said five-membered or six-membered heteroaromatic ring is optionally substituted by one or more C.sub.1-6 alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, pyridyl(C.sub.1-6)alkyl, halogen, halo(C.sub.1-6)alkyl, cyano, cyano(C.sub.1-6)alkyl, hydroxy, hydroxymethyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl(C.sub.1-6)alkoxy, C.sub.3-7 cycloalkoxy, amino(C.sub.1-6)alkyl, di(C.sub.1-6)alkylamino(C.sub.1-6)alkyl, di(C.sub.1-6)alkylaminocarbonyl(C.sub.1-6)alkyl, N-(C.sub.1-6)alkylpiperidinyl, pyrrolidinyl(C.sub.1-6)alkyl, piperazinyl(C.sub.1-6)alkyl, morpholinyl(C.sub.1-6)alkyl, di(C.sub.1-6)alkylmorpholinyl(C.sub.1-6)alkyl or imidazolyl(C.sub.1-6)alkyl substituents; andR.sup.2 represents pyridinyl(C.sub.1-6)alkyl, imidazolyl(C.sub.1-6)alkyl, or triazolyl(C.sub.1-6)alkyl, any of which groups may be optionally substituted by one or more C.sub.1-6 alkyl, phenyl(C.sub.1-6)alkyl, naphthyl(C.sub.1-6)alkyl, pyridyl(C.sub.1-6)alkyl, halogen, halo(C.sub.1-6)alkyl, cyano, cyano(C.sub.1-6)alkyl, hydroxy, hydroxymethyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl(C.sub.1-6)alkoxy, C.sub.3-7 cycloalkoxy, amino(C.sub.1-6)alkyl, di(C.sub.1-6)alkylamino(C.sub.1-6)alkyl, di(C.sub.1-6)alkylaminocarbonyl(C.sub.1-6)alkyl, N-(C.sub.1-6)alkylpiperidinyl, pyrrolidinyl(C.sub.1-6)alkyl, piperazinyl(C.sub.1-6)alkyl, morpholinyl(C.sub.1-6)alkyl, di(C.sub.1-6)alkylmorpholinyl(C.sub.1-6)alkyl or imidazolyl(C.sub.1-6)alkyl substituents; andZ.sup.2 is pyridyl, tertiary butyl, cyclobutyl or methylcyclobutyl.