Patent ID: 6166244
Filing Date: 2000-12-26
Classification: A61P,C07C,C07F

Abstract:
A compound having the structure in accordance with a formula selected from the group consisting of formulas 1, 2, 3 and 4, ##STR16## wherein R, R.sub.1, R.sub.2 and R.sub.3 are H, lower alkyl of 1 to 10 carbons, cycloalkyl of 3 to 10 carbons, halogen, (C.sub.1-10 -lower alkyl).sub.3 -silyl, C.sub.1-10 -lower alkylphenyl, or phenyl-C.sub.1-10 -lower alkyl,n is an integer having the values of 0 to 6;W is O, S, C(R).sub.2, CRCO.sub.2 R, NR, NOR, NN(R).sub.2 ;W.sub.1 is OR, SR, N(R).sub.2, RC(O)O, NRC(O)R, NRC(S)R, NRC(O)N(R).sub.2, or NRC(S)N(R).sub.2 ;X is C.ident.C, C(O)O, or (CR.dbd.CR).sub.n' where n' is an integer having the values 1 to 5;Y is a phenyl or naphthyl group, said phenyl and naphthyl groups being optionally substituted with one or two R groups, orwhen X is --(CR.dbd.CR).sub.n' -- and n' is 3, 4 or 5 then Y represents a direct valence bond between said (CR.dbd.CR).sub.n' group and B;A is (CH.sub.2).sub.q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds;B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 OR.sub.13 O, or tri-lower alkylsilyl, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons or (trimethylsilyl)alkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons, or a pharmaceutically acceptable salt of said compound, with the proviso that when X is C.ident.C, Y is phenyl then in the compounds of Formula 1 W is not oxygen (O).