Patent ID: 6727271
Filing Date: 2004-04-27
Classification: C07D

Abstract:
A method for lowering blood glucose levels or for treating diabetes, or a dysplastic disease, which comprises administering to a patient in need of treatment a therapeutically effective amount of a compound which has the structure wherein x is 1,2,3 or 4; m is 1 or 2; n is 1 or 2;Q is C; A is O; Z is O; R1 is H or lower alkyl; X is CH; R2 is H or alkyl; R2a, R2b and R2c are the same or different and are selected from H or alkyl; R3 is aryloxycarbonyl, alkyloxycarbonyl, alkynyloxycarbonyl, alkenyloxycarbonyl, alkoxyaryloxycarbonyl, arylalkyloxycarbonyl, alkylaryloxycarbonyl, alkynyloxycarbonyl, Y is CO2R4 where R4 is H or alkyl, or a prodrug ester; or stereoisomers thereof, a prodrug ester thereof, and a pharmaceutically acceptable salt thereof.