Patent ID: 8304388
Filing Date: 2012-11-06
Classification: A61K

Abstract:
1. An imaging agent comprising a collagen binding peptide (CBP) and an imaging moiety, wherein said CBP is selected from: a) ANAALKAGELYKCILY-NH b) ANAALKAGELYK-[Abu]-ILY-NH c) Ac-ANAALKAGELFK-[Abu]-ILY-NH d) Ac-ANAALKAGELYK-[Abu]-ILF-NH e) Ac-ANAALKAGELY-[NMeLys]-[Abu]-ILF-NH f) Ac-AN-[NMeAla]-ALKAGELYK-[Abu]-ILF-NH g) Ac-AN-[NMeAla]-ALKAGELY-[NMeLys]-[Abu]-ILF-NH h) ANAALKAGELYK-[Abu]-ILY-[PEG(4)]-[diglycolyl]-NH i) ANAALKAGELY-[NMeLys]-[Abu]-ILY-[PEG(4)]-[diglycolyl]-NH j) ANAALKAGELYK-[Abu]-ILY-[PEG(4)]-[diglycolyl]-COOH, SEQ ID NO. 19; k) D-YLI-[Abu]-KYLEGAKLAANA-NH l) GELYKCILY-NH wherein “Ac” is an acetyl group, “Abu” is 2-aminobutyric acid, “NMeLys” is N-methylated lysine, “NMeAla” is N-methylated alanine, and “PEG(X)” is a polyethylene glycol chain of X units; and wherein said imaging moiety is either an integral part of the CBP or is conjugated to the CBP via a suitable chemical group.