Patent ID: 6410530
Filing Date: 2002-06-25
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having the formula (I) whereinX is CH; Y is NR2CH2, CH2â€”NR2, NR2â€”CO, COâ€”NR2 or NR2SO2; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)nâ€” aromatic ring, wherein the aromatic ring is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and wherein the aromatic ring may be mono- or di-substituted with R4 and/or R5; R4 is H, C1-C6 alkyl, C3-C6 cycloalkyl, halogen, CN, CF3, OH, C1-C6 alkoxy, NR6R7, OCF3, SO3CH3, SO3CF3, SO2NR6R7, phenyl, phenyl-C1-C6 alkyl, phenoxy, C1-C6 alkyl phenyl, C1-C6 alkyl-heterocyclic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO2, an optionally substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO2 wherein the optional substituent(s) may be selected from C1-C6 alkyl, C3-C6 cycloalkyl and phenyl-C1-C6 alkyl; or COR8; R5 is H, OH, CF3, OCF3, halogen, C1-C6 alkyl or C1-C6 alkoxy; R6 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R7 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R8 is C1-C6 alkyl, C3-C6 cycloalkyl, CF3, NR6R7, phenyl, or a heterocyclic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO2; n is 0-4; as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof.