Patent ID: 6444268
Filing Date: 2002-09-03
Classification: B05D,B32B,B82Y,G01N,Y10T

Abstract:
A process for synthesizing an oligomer array on a substrate surface, comprising:(a) functionalizing a substrate surface by contacting a substrate having reactive hydrophilic moieties on the surface thereof with a derivatizing composition comprising a first silane R1â€”Si(RLRxRy) and a second silane R2â€”(L)nâ€”Si(RLRxRy) under reaction conditions effective to couple the silanes to the substrate surface and provide â€”Siâ€”R1 groups and â€”Siâ€”(L)nâ€”R2 groups thereon, wherein the RL, moieties, which may be the same or different, are groups which leave the silanes during the coupling, the Rx and Ry are independently lower alkyl or leaving groups, R1 is a chemically inert moiety that upon binding to the substrate surface lowers the surface energy thereof, n is 0 or 1, L is a linking group, and R2 is a functional group enabling covalent binding of a molecular moiety or a modifiable group that is capable of being converted to such a functional group; and (b) synthesizing a plurality of substrate-bound oligomers at each R2 by sequentially coupling monomers thereto, wherein array features are created by the separation of individual coupling reactions as the oligomers are synthesized so as to form an oligomer array on the functionalized surface provided in (a); wherein the substrate comprises a polymeric material, silica, glass, or ceramic.