Patent ID: 7678793
Filing Date: 2010-03-16
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating depression in mammals comprising administering to the mammal a therapeutically effective amount of a compound of Formula (1): and isomers thereof, stereoisomeric forms thereof, or mixtures of stereoisomeric forms thereof, and pharmaceutically acceptable salt forms thereof, wherein: Ar is selected from phenyl, pyridyl and 2,3-dihydrobenzofuranyl, each Ar optionally substituted with 1 to 4R R R R R alternatively, NR R R R R R R aryl is phenyl or naphthyl, each optionally substituted with 1 to 5 substituents independently selected at heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, pyranyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzothiazolyl, isoxazolyl, pyrazolyl, 2,3-dihydrobenzothienyl or 2,3-dihydrobenzofuranyl, each being optionally substituted with 1 to 5 substituents independently selected at each occurrence from C heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 5 substituents independently selected at each occurrence from C n is independently at each occurrence 0, 1 or 2.