Patent ID: 8980311
Filing Date: 2015-03-17
Classification: A61K,A61P,B01J,C07K,C12N,G01N,Y02A

Abstract:
1. A method for making a multicomponent compound comprising: mixing at least one first hydrophobic reactant comprising a carbohydrate and an N-terminal cysteine residue, at least one second hydrophobic reactant comprising a lipopeptide thioester, and a nonpolar, hydrophobic or amphipathic molecule capable of forming a lipidic structure; subjecting the mixture to conditions effective to form a lipidic structure in which the first and second reactants are embedded; and subjecting first and second reactants to conditions effective to allow ligation of the first reactant and the second reactant to yield a multicomponent compound comprising the first and second reactant, wherein the ligation reaction takes place within the lipid phase of the lipidic structure; wherein neither the first nor the second reactant is a transmembrane protein or membrane-spanning fragment thereof.