Patent ID: 7955824
Filing Date: 2011-06-07
Classification: C07D,Y02P

Abstract:
1. A method for the preparation of a compound of formula (II): wherein R 1 is H, unsubstituted lower alkyl, or substituted lower alkyl; the method comprising the steps of growing a host cell comprising a polyketide synthase in a medium comprising a thioester of formula (I) wherein R 4 is C 1 -C 10 alkyl; or R 4 is CH 2 CO 2 R 6 , wherein R 6 is lower alkyl; or R 4 is CH 2 CH 2 NH(CO)R 5 , wherein R 5 is C 1 -C 10 alkyl, under conditions wherein the polyketide synthase converts the thioester of formula (I) into the compound of formula (II).