Patent ID: 6995238
Filing Date: 2006-02-07
Classification: A61K,A61P,C07K,Y02P

Abstract:
1. A process for promoting the integration of a device which is useful as an implant or of a biocompatible device into tissue which contains integrin bearing cells, said process comprising covalently bonding to the surface of said device which is useful as an implant or of said biocompatible device a compound of the following formula I in which R is cyclo-(Arg-Gly-Asp-Z), where Z is bonded via a side chain to Q, or if Q is absent, to X, Q is absent, or is —(CO—R —(NH—CH —(NH—CH —(CO—CH X is —CO—CH═CH Z is in each case independently of one another an amino acid residue or a di- or tripeptide residue, where the amino acids independently of one another are selected from a group consisting of Ala, Asn, Asp, Ag, Cys, Gln, Glu, Gly, His, Homo-Phe, Ile, Leu, Lys, Met, Phe, Phg, Pro, Ser, Thr, Trp, Tyr, Val and M, wherein said amino acids can be derivatized, and the amino acid residues are linked to one another in peptide fashion via the α-amino- and α-carboxyl groups, and where M is always present, M is a residue of NH(R R R R R R R R R R R A is alkyl having 1-6 C atoms, Hal is F, Cl, Br or I m and n in each case independently of one another are 0, 1, 2 or 3 and p is 1, 2, or 3, where each optically active amino acid or amino acid derivative that is present is in either the D or L form; or a salt thereof, thereby producing a coated device, and bringing said coated device into contact with tissue.