Patent ID: 8921307
Filing Date: 2014-12-30
Classification: A61K,C07K

Abstract:
1. A polypeptide having the following formula (SEQ ID NO: 1): wherein: X1 is the N-terminus of the polypeptide and is either absent or pE; X2 is R or r; X3 is P or 4-PhP; X5 is L, Cha, D-L, F, Y, Y(Bzl), 3,4-Cl2-F or Nal; X6 is a D-amino acid, S or A; X7 is a D-amino acid, L, H or Aib; and at least one of X6 and X7 is D-amino acid or Aib; X8 is K, k, Q or E; X9 is G or D; X10 is P or pipecolic acid; X11 is D-Nle, Nle, f or D-Nva; X12 is absent, P or a D-amino acid; X13 is the C-terminus and is absent, F or a D-amino acid; and at least one of X11, X12 and X13 is a D-amino acid; wherein: Nle is L-norleucine; D-Nle is D-norleucine; Nal is L-naphthyl)alanine; D-Nva is D-norvaline; Aib is α-aminoisobutyric acid; Cha is (S)-β-cyclohexylalanine; D-Tic is D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; pE is L-pyroglutamic acid; 3,4-Cl2-F is (S)-3,4-dichlorophenylalanine; Y is L-tyrosine; and Y(Bzl) is L-benzyl-tyrosine; or an amide, an ester or a salt of the polypeptide.