Patent ID: 9199978
Filing Date: 2015-12-01
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt and solvate thereof, wherein: A represents ═S or —SR4; X represents F, Cl, Br or I; R1 represents thienyl or substituted thienyl, wherein said substituted thienyl is substituted with 1-3 substituents selected from halogens, nitro, hydroxyl, amino, cyano, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 halogenated alkyl, and wherein said alkyl, alkoxy and halogenated alkyl is optionally substituted with hydroxy, —O—(C1-C4)-alkyl, oxo, amino, —NH—(C1-C4)-alkyl, or —N—[(C1-C6)-alkyl]2, or said alkyl, alkoxy and halogenated alkyl is optionally substituted with —O—,—S—,—NH—,—COO—; R2, R3 each individually represent hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, C1-C6 alkoxy, amino C1-C6 alkyl, mono-substituted or di-substituted amino C1-C6 alkyl, phenyl C1-C6 alkyl, substituted phenyl C1-C6 alkyl, phenyl, substituted phenyl, wherein R2 and R3 may be attached together to form a saturated cyclic alkyl, nitrogen- or oxygen-containing heterocyclic group; and R4 represents C1-C6 alkyl.