Patent ID: 7488791
Filing Date: 2009-02-10
Classification: A61K,A61P,C07K,C12N,G01N,Y02A

Abstract:
1. An isolated composition of a mixture of at least two peptides derived from an E6 protein of an HPV involved in cervical cancer or benign lesions of the skin, wherein: each of the peptides included in the mixture binds, with a binding activity <1000 nM, to at least one HLA-DRB1 molecule the frequency of which is greater than 5% in the Caucasian population, the mixture of peptides binding to at least eight HLA class II molecules, the frequency of which is greater than 5% in the Caucasian population, encoded by the alleles selected from the group consisting of the alleles HLA DRB1*0101, HLA DRB1*0401, HLA DRB1*0701, HLA DRB1*1101, HLA DRB1*1301, HLA DRB1*1501, HLA DRB3*0101, HLA DRB4*0101 and HLA DRB5*0101, one of the peptides has at least 95% identity to SEQ ID NO: 21; and one of the peptides has at least 95% identity to SEQ ID NO: 26.