Patent ID: 6608097
Filing Date: 2003-08-19
Classification: A61P,C07D

Abstract:
A calcium channel blocker compound having the following structure:R4=wherein:X=a bond, (CH2)n, O, S, or O(CH2)n, R=C1-6 alkyl, optionally substituted with OH or NH2; R2=F or COOR5, wherein R5 is C1-6 alkyl, optionally substituted with OH or NH2; R3=CH3 or (CH2)nâ€”COOR6, wherein R6 is C1-6 alkyl, optionally substituted with OH or NH2; R7=O, NH, or NR9, R8=optionally substituted aryl or heterocycle, R9=C1-6 alkyl, R10=O, S, SO, SO2, NH, NR12 or N(CH2)m COOR13, R11=aryl or heterocyclyl optionally substituted with (CH2)n COOR14, R12=C1-6 alkyl, optionally substituted with OH or NH2, R13=C1-6 alkyl, optionally substituted with OH or NH2, R14=C1-6 alkyl, optionally substituted with OH or NH2, R15=(CH2)n COOR16, R16=C1-6 alkyl, optionally substituted with OH or NH2, R17=not present or COOR18 wherein R18 is C1-6 alkyl, optionally substituted with OH or NH2, and wherein n=1-6 and m=O or 1.