Patent ID: 9090707
Filing Date: 2015-07-28
Classification: A61K,A61P,C07K

Abstract:
1. An isolated peptide consisting essentially of the molecule having the amino acid sequence formula of (B#)(VnQnRnQnTnTcTcVcVcAn)(Z#), wherein Vn, Qn, Rn, Qn, Tn, and An represent the amino acids V, Q, R, T and A and non-conservative and conservative amino acid substitutions thereof; wherein Tc and Vc represent the amino acids T and V and conservative substitutions thereof; wherein B and Z are any of the known 20 amino acids or derivatives thereof; wherein “#” is 0 or 1 for B and 0 to 3 for Z; wherein said peptide binds VEGF or enhances VEGF binding to cells in an in vitro assay; wherein said peptide is not a peptide comprising an amino acid sequence of DRVQRQTTTVVA (SEQ ID NO: 1); and wherein said peptide is not a peptide comprising an amino acid sequence of DRVQRQTTTVVA (SEQ ID NO: 1) having an amino acid substitution at one or more of positions 2, 3, 4, 5, 6, 7 or 12.