Patent ID: 6114376
Filing Date: 2000-09-05
Classification: A61K,A61P,C07D

Abstract:
A method for increasing the toxicity of a cytostatic hydrophobic chemotherapeutic agent against a resistant tumor cell in a mammal which comprises administering a multidrug resistant reversing agent to the mammal in connection with administering the cytostatic hydrophobic chemotherapeutic agent in an amount effective to increase the toxicity of the chemotherapeutic agent, wherein the multidrug resistant reversing agent is a macrocyclic lactone compound selected from the group consisting of LL-F28249.alpha.-.lambda., a 23-oxo derivative of LL-F28249.alpha.-.lambda., a 23-imino derivative of LL-F28249.alpha.-.lambda., an avermectin, a 22,23-dihydro derivative of avermectin and a milbemycin.