Patent ID: 7745450
Filing Date: 2010-06-29
Classification: A61P,C07D

Abstract:
1. A 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidine compound represented by the formula I and a pharmaceutically acceptable salt thereof, wherein R3 is selected from the group consisting of a C R R wherein in R5 and R7, each of the C wherein in R3, each of the alkyl, alkenyl, alkynyl, alkylene, alkenylene, and alkynylene is independently optionally substituted with one or more substituents selected from the group consisting of hydroxyl, mercapto, alkylmercapto, halogen, alkoxy, acyloxy, amino, acylamino, hydrazino, carbamoyl, amido, carboxyl, sulfo, acyl and guanidine; the aryl is optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl, hydroxy, amino, acylamino, carbamoylamino, hydrazino, mercapto, alkoxy, alkylmercapto, alkylamino, amido, carboxyl, nitro and sulfo; the cycloalkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, amino, hydroxy, cyano, nitro, mercapto, alkoxy, alkylamino, acylamino, carbamoylamino, acyloxy, dialkylamino, alkylmercapto, carboxyl, amido, sulfo and sulfamido; and the cycloheteroalkyl is optionally substituted or unsubstituted with one or more substituents selected from the group consisting of halogen, amino, hydroxy, cyano, nitro, mercapto, alkoxy, alkylamino, acylamino, carbamoylamino, acyloxy, dialkylamino, alkylmercapto, carboxyl, amido, sulfo and sulfamido.