Patent ID: 6316490
Filing Date: 2001-11-13
Classification: B64C,Y02T

Abstract:
A compound having the Formula (Z) as follows:A--D--E--G (Z)or enantiomers, diastereomeric isomers or mixtures of any two or more thereof, or pharmaceutically acceptable salts thereof, wherein:A has the structure (I): ##STR13##wherein:each of R.sub.1, R.sub.2, R.sub.4, and R.sub.5 is independently hydrogen, lower alkyl, or halogen;R.sub.3 is:--O--C(O)--N(CH.sub.3).sub.2,--CH.sub.2 --NHSO.sub.2 --R.sub.D,--O--C(O)--R.sub.A,--O--R.sub.A,hydroxy,amino,amino(toluenesulfonate),--NHSO.sub.2 --R.sub.A,--NHSO.sub.2 --N(R.sub.A).sub.2,--C(O)--OH, or--CH.sub.2 --NHSO.sub.2 --R.sub.Awherein R.sub.A is --CH.sub.3 or --CF.sub.3 ;R.sub.D is hydrogen, or lower alkyl;D is --S--;E is --CH.sub.2 --CH.sub.2 --; andG is a nitrogen-containing cyclic moiety having the structure (II): ##STR14##wherein R.sub.D is hydrogen, or lower alkyl.