Patent ID: 7053109
Filing Date: 2006-05-30
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 and R 1 ′ are the same or different and are C C aryl or aryl(C C C C C R and R′ independently are hydrogen, C R 2 is H; R C is hydrogen, —(CR 245 R 250 ) 0-4 -aryl, —(CR 245 R 250 ) 0-4 -aryl-aryl, —CH(aryl) 2 , —(CH 2 ) 0-1 —CH((CH 2 ) 0-6 —OH)-(CH 2 ) 0-1 -aryl, —CH-aryl-CO—O(C 1 –C 4 alkyl), or C —(CH cyclopentyl, cyclohexyl, or cycloheptyl ring fused to aryl, wherein the cyclopentyl, cyclohexyl, or cycloheptyl group is optionally substituted with one or two groups that are independently R C each aryl is optionally substituted with 1, 2, or 3 R R 200 at each occurrence is independently selected from —OH, —NO 2 , halogen, —CO 2 H, C≡N, —(CH 2 ) 0-4 —CO—NR 220 R 225 , —(CH 2 ) 0-4 —CO—(C 1 –C 12 alkyl), —(CH 2 ) 0-4 —CO—(C 2 –C 12 alkenyl), —(CH 2 ) 0-4 —CO—(C 2 –C 12 alkynyl), —(CH 2 ) 0-4 —CO—(C 3 –C 7 cycloalkyl), —(CH 2 ) 0-4 —CO-aryl, —(CH 2 ) 0-4 —CO-heteroaryl, —(CH 2 ) 0-4 —CO-heterocyclyl, —(CH 2 ) 0-4 —CO—O—R 215 , —(CH 2 ) 0-4 —SO 2 —NR 220 R 225 , —(CH 2 ) 0-4 —SO—(C 1 –C 8 alkyl), —(CH 2 ) 0-4 —SO 2 -(C 1 –C 12 alkyl), —(CH 2 ) 0-4 —SO 2 -(C 3 –C 7 cycloalkyl), —(CH 2 ) 0-4 —N(H or R 215 )-CO—O—R 215 , —(CH 2 ) 0-4 —N(H or R 215 )-CO—N(R 215 ) 2 , —(CH 2 ) 0-4 —N—CS—N(R 215 ) 2 , —(CH 2 ) 0-4 —N(—H or R 215 )-CO—R 220 , —(CH 2 ) 0-4 —NR 220 R 225 , —(CH 2 ) 0-4 —O—CO—(C 1 –C 6 alkyl), —(CH 2 ) 0-4 —O—P(O)-(OR 240 ) 2 , —(CH 2 ) 0-4 —O—CO—N(R 215 ) 2 , —(CH 2 ) 0-4 —O—CS—N(R 215 ) 2 , —(CH 2 ) 0-4 —O—(R 215 ), —(CH 2 ) 0-4 —O—(R 215 )-COOH, —(CH 2 ) 0-4 —S—(R 215 ), —(CH 2 ) 0-4 —O—(C 1 –C 6 )alkyl optionally substituted with 1, 2, or 3 —F, C 3 –C 7 cycloalkyl, —(CH 2 ) 0-4 —N(H or R 215 )-SO 2 —R 220 , —(CH 2 ) 0-4 —C 3 –C 7 cycloalkyl, C C the aryl and heteroaryl groups at each occurrence are optionally substituted with 1, 2, or 3 groups that are independently R the heterocyclyl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R R 205 at each occurrence is independently selected from C 1 –C 6 alkyl, halogen, —OH, —O-phenyl, —SH, —S—C 1 –C 6 alkyl, —C≡N, —CF 3 , C 1 –C 6 alkoxy, NH 2 , NH(C 1 –C 6 alkyl) or N—(C 1 –C 6 alkyl)(C 1 –C 6 alkyl); R 210 at each occurrence is independently selected from halogen, C 1 –C 6 alkoxy, C 1 –C 6 haloalkoxy, —NR 220 R 225 , OH, C≡N, —CO—(C 1 –C 4 alkyl), —SO 2 —NR 235 R 240 , —CO—NR 235 R 240 , —SO 2 -(C 1 –C 4 alkyl), ═O, or C R 215 at each occurrence is independently selected from C 1 –C 6 alkyl, —(CH 2 ) 0-2 -(aryl), C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, and —(CH 2 ) 0-2 -(heteroaryl), —(CH 2 ) 0-2 -(heterocyclyl), wherein the aryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R the heterocyclyl and heteroaryl groups at each occurrence are optionally substituted with 1, 2, or 3 independently selected R R 220 and R 225 at each occurrence are independently selected from —H, —C 3 –C 7 cycloalkyl, —(C 1 –C 2 alkyl)-(C 3 –C 7 cycloalkyl), —(C 1 –C 6 alkyl)-O—(C 1 –C 3 alkyl), —C 2 –C 6 alkenyl, —C 2 –C 6 alkynyl, —C 1 –C 6 alkyl chain with one double bond and one triple bond, -aryl, -heteroaryl, and -heterocyclyl, and —C the aryl, heterocyclyl and heteroaryl groups at each occurrence are optionally substituted with 1, 2, or 3 independently selected R R 235 and R 240 at each occurrence are independently H, or C 1 –C 6 alkyl; R 245 and R 250 at each occurrence are independently selected from —H, C 1 –C 4 alkyl, C 1 –C 4 alkylaryl, C 1 –C 4 alkylheteroaryl, C 1 –C 4 hydroxyalkyl, C 1 –C 4 alkoxy, C 1 –C 4 haloalkoxy, —(CH 2 ) 0-4 —C 3 –C 7 cycloalkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, and phenyl; or R 245 and R 250 are taken together with the carbon to which they are attached to form a carbocycle of 3, 4, 5, 6, or 7 carbon atoms, where one carbon atom is optionally replaced by a heteroatom selected from —O—, —S—, —SO 2 —, and —NR 220 —; R 270 at each occurrence is independently R 205 , halogen C 1 –C 6 alkoxy, C 1 –C 6 haloalkoxy, NR 235 R 240 , —OH, —C≡N, —CO—(C 1 –C 4 alkyl), —SO 2 —NR 235 R 240 , —CO—NR 235 R 240 , —SO 2 -(C 1 –C 4 alkyl), ═O, or C R N is —C(═O)-(CRR′) 0-6 R 100 ; R 100 is heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from —OR, —NO W is (CR R 102 and R 102′ independently are hydrogen, or C R 105 and R′ 105 independently represent —H, —R 110 , —R 120 , C 3 –C 7 cycloalkyl, —(C 1 –C 2 alkyl)-(C 3 –C 7 cycloalkyl), —(C 1 –C 6 alkyl)-O—(C 1 –C 3 alkyl), C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, or C 1 –C 6 alkyl chain with one double bond and one triple bond, or C C R 105 and R′ 105 together with the atom to which they are attached form a 3 to 7 membered carbocylic ring, where one member is optionally a heteratom selected from —O—, —S(O) 0-2 —, —N(R 135 )—, the ring being optionally substituted with 1, 2 or 3 independently selected R 140 groups; R 115 at each occurrence is independently halogen, —OH, —CO 2 R 102 , —C 1 –C 6 thioalkoxy, —CO 2 -phenyl, —NR 105 R′ 135 , —SO 2 -(C 1 –C 8 alkyl), —C(═O)R 180 , R 180 , —CONR 105 R′ 105 , —SO 2 NR 105 R′ 105 , —NH—CO—(C 1 –C 6 alkyl), —NH—CO—R 110 , —NH—CO—R 120 , —NH—C(═O)—OH, —NH—C(═O)—OR, —NH—C(═O)—O-phenyl, —O—C(═O)-(C 1 –C 6 alkyl), —O—C(═O)-amino, —O—C(═O)-mono- or dialkylamino, —O—C(═O)-phenyl, —O—(C 1 –C 6 alkyl)-CO 2 H, —NH—SO 2 -(C 1 –C 6 alkyl), C 1 –C 6 alkoxy or C 1 –C 6 haloalkoxy; R 135 is C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, —(CR 2 ) 0-2 -(aryl), —(CH 2 ) 0-2 -(heteroaryl), or —(CH 2 ) 0-2 -(heterocyclyl); R 140 is heterocyclyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C 1 –C 6 alkyl, C 1 –C 6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono(C 1 –C 6 )alkylarnino, di(C 1 –C 6 )alkylamino, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 haloalkyl, C 1 –C 6 haloalkoxy, amino(C 1 –C 6 )alkyl, mono(C 1 –C 6 )alkylamino(C 1 –C 6 )alkyl, di(C 1 –C 6 )alkylamino(C 1 –C 6 )alkyl, and ═O; R 145 is C 1 –C 6 alkyl or CF 3 ; R 150 is hydrogen, C 3 –C 7 cycloalkyl, —(C 1 –C 2 alkyl)-(C 3 –C 7 cycloalkyl), C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or C R 150 ′ is C 3 –C 7 cycloalkyl, —(C 1 –C 3 alkyl)-(C 3 –C 7 cycloalkyl), C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or C R 155 is C 3 –C 7 cycloalkyl, —(C 1 –C 2 alkyl)-(C 3 –C 7 cycloalkyl), C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or C R 180 is selected from morpholinyl, thiomorpholinyl, piperazinyl, piperidinyl, homomorpholinyl, homothiomorpholinyl, homothiomorpholinyl S-oxide, homothiomorpholinyl S,S-dioxide, pyrrolinyl and pyrrolidinyl, each of which is optionally substituted with 1, 2, 3, or 4 groups independently selected from C 1 –C 6 alkyl, C 1 –C 6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono(C 1 –C 6 )alkylamino, di(C 1 –C 6 )alkylamino, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 haloalkyl, C 1 –C 6 haloalkoxy, amino(C 1 –C 5 )alkyl, mono(C 1 –C 6 )alkylamino(C 1 –C 6 )alkyl, di(C 1 –C 6 )alkylamino(C 1 –C 6 )alkyl, and ═O; R 110 is aryl optionally substituted with 1 or 2 R 125 groups; R 125 at each occurrence is independently halogen, amino, mono- or dialkylamino, —OH, —C≡N, —SO 2 —NH 2 , —SO 2 —NH—C 1 –C 6 alkyl, —SO 2 —N(C 1 –C 6 alkyl) 2 , —SO 2 -(C 1 –C 4 alkyl), —CO—NH 2 , —CO—NH—C 1 –C 6 alkyl, or —CO—N(C 1 –C 6 alkyl) 2 , or C C R 120 is heteroaryl, which is optionally substituted with 1 or 2 R 125 groups; and R 130 is heterocyclyl optionally substituted with 1 or 2 R 125 groups.