Patent ID: 8063062
Filing Date: 2011-11-22
Classification: A61P,C07D

Abstract:
1. A compound of formula (1): or a tautomer, stereoisomer, N-oxide, or a pharmacologically acceptable salt of any of the foregoing, wherein: A is chosen from one of: wherein X is a sulfonyl or a carbonyl group, the sign + is the position at which one of (A 1a ) to (A 8 ) is connected to T of formula (1), each of R 1 , R 2 and R 3 is chosen from a hydrogen atom, a trifluoromethyl group, and a halogen atom, R 4 is chosen from a hydrogen atom, a halogen atom, a methyl group, an ethyl group, a trifluoromethyl group, a hydroxymethyl group, a fluoromethyl group, a 2,2,2-trifluoroethyl group, a propyl group, a methylsulfanyl group, a methylsulfinyl group, a methylsulfonyl group, an ethylsulfanyl group, an ethylsulfinyl group, an ethylsulfonvl group, a C 1-3 -dialkyl-aminomethyl group, a pyrrolidin-1-ylmethyl group, a piperidin-1-ylmethyl group, and a morpholin-4-ylmethyl group, and R is a hydrogen atom or a C 1-3 alkyl group; T is chosen from a saturated or unsaturated linear carbon chain having from 2 to 8 carbon atoms, wherein the carbon chain is optionally substituted with from 1 to 5 substituents chosen from a methyl group, an ethyl group, a hydroxy group, a fluoro atom, and an amino group, and wherein the carbon chain optionally comprises an additional nitrogen atom, optionally substituted with a C B is chosen from one of: wherein the “+” symbol is the position at which one of (B1) to (B3) is connected to T of formula (1), R 5 is chosen from a hydrogen atom, a halogen atom, a methoxy group, and a trifluoromethoxy group, and m is 0, 1 or 2; and n is 0 or 1.