Patent ID: 6613536
Filing Date: 2003-09-02
Classification: A61K,C07K,G01N

Abstract:
A synthetic peptide selected from the group consisting of:(i) a peptide of at least 12 and at most 30 amino acid residues consisting of a sequence including a complementarity-determining region found in the heavy or light chain of a pathogenic anti-DNA monoclonal antibody that induces a systemic lupus erythematosus (SLE)-like disease in mice, or a salt thereof or the reaction product thereof with an organic derivatizing agent capable of reacting with selected side chains or terminal residues, which reaction product retains at least a portion of the function of the peptide to inhibit specifically the proliferative response and cytokine secretion of T lymphocytes of mice that are high responders to SLE-inducing autoantibodies; (ii) a dual synthetic peptide comprising two different ones of said peptides of (i) covalently linked to one another either directly or through a short linking chain; (iii) a peptide polymer comprising a plurality of sequences of said peptide (i); and (iv) a peptide polymer of (iii) attached to a macromolecular carrier.