Patent ID: 8951801
Filing Date: 2015-02-10
Classification: C12N

Abstract:
1. A method of making induced pluripotent stem iPS cells, comprising the step of introducing a nuclear reprogramming substance into a somatic cell, wherein the nuclear reprogramming substance comprises the following (1), (2), (3), or (4): (1) Oct3/4, Sox2, and GLIS family zinc finger 1 (GLIS1), or nucleic acids that encode the same, (2) Oct3/4, Sox2, and DMRTB1, or nucleic acids that encode the same, (3) Oct3/4, Sox2, c-Myc, and iroquois homeobox protein 6 (IRX6), or nucleic acids that encode the same, or (4) Oct3/4, c-Myc, and paired-like homeodomain transcription factor 2 isoform b (PITX2), or nucleic acids that encode the same.