Patent ID: 6086376
Filing Date: 2000-07-11
Classification: A61K,Y10S

Abstract:
A dry suspension aerosol formulation having a density in the range of from 1.0 to 1.5 g/ml consisting essentially of stabilized drug microcrystals in a mean size range of 0.1 to 10 microns as a core coated with an envelope of one or more membrane-forming phospholipids and at least one surfactant surrounding the drug core and dispersed in 1,1,1,2-tetrafluoroethane HFA134a or 1,1,1,2,3,3,3-heptafluoropropane HFA 227 propellant, wherein the density of the coated drug microparticles substantially matches the density of the propellant and the amount of phospholipid coating on the drug microparticles is more than 0.1% and less than 200% of the weight of the drug.