Patent ID: 7744914
Filing Date: 2010-06-29
Classification: A61F

Abstract:
1. A vascular graft comprising a surface with a micropattern of parallel grooves and plateau regions, wherein vascular smooth muscle cells (VSMCs) can adhere and orient along said grooves, wherein the grooves have a depth of 1 to 10 μm, and a width of 1 to 20 μm, and the micropattern reduces proliferation of the VSMCs, wherein the graft is fabricated from a polymeric material selected from the group consisting of poly-(D,L-lactide-co-glycolide) (PLGA), poly-(dimethylsiloxane) (PDMS), poly-(L-lactide-co-caprolactone-co-glycolide) (PLCG), polycaprolactone (PCL), polylactic acid (PLA), polystyrene, polyurethane, ePTFE, and polyethylene terephthalate.