Patent ID: 6613905
Filing Date: 2003-09-02
Classification: A61P,C07D

Abstract:
A compound represented by the following structural formula: or physiologically acceptable salt thereof, wherein: n is an integer from one to four; M is >CR1R2; R1 is â€”H, â€”OH, an aliphatic group, â€”O-(aliphatic group), â€”O-(substituted aliphatic group), â€”SH, â€”S-(aliphatic group), â€”S-(substituted aliphatic group), â€”OC(O)-(aliphatic group), â€”Oâ€”C(O)-(substituted aliphatic group), â€”COOH, â€”COâ€”NR3R4 or â€”NR3R4; and R2 is â€”OH, an acyl group, a substituted acyl group, â€”NR5R6, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; wherein: R3, R4, R5 and R6 are independently an acyl group, a substituted acyl group, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; or R1 and R2, R3 and R4, or R5 and R6 taken together with the atom to which they are bonded, form a substituted or unsubstituted non-aromatic carbocyclic or heterocyclic ring; said acyl group is selected from the group consisting of aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl and aromatic sulfonyl; Z is represented by the following structural formula: â€ƒwherein: X1 is â€”NRcâ€”CH2â€”, â€”CH2â€”NRcâ€”, â€”NRcâ€”COâ€” or â€”COâ€”NRcâ€”; Rc is a substituted C1-C20 aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group or a substituted benzyl group; and Ring A and Ring B are independently substituted or unsubstituted.