Patent ID: 6841561
Filing Date: 2005-01-11
Classification: A61K,C07D,Y02A

Abstract:
1. A method of treating a host infected with a virus of the Flaviviridae, Rhabdoviridae or Paramyxoviridae family, which method comprises administering to the host an inhibitor of dihydroorotate dehydrogenase, wherein the inhibitor is a compound of the formula (I): wherein each A is independently selected from the group consisting of hydrogen, hydroxy, halogen, perhaloalkoxy, amino C R is cyclohexyl, phenoxy or benzoxy, or a phenyl ring which is unsubstituted or substituted by a group A as defined above; or R and an adjacent group A on ring b form, together with the phenyl ring to which they are attached, a naphthalene or phenanthrene ring system; Y is selected from the group consisting of COOM, CONHR′, SO M is selected from the group consisting of H, Li, Na, K and 0.5 Ca; R′ is C n is 1 or 2; and T is =N or =C(Z) wherein either: