Patent ID: 7074392
Filing Date: 2006-07-11
Classification: A61K,A61P,A61Q

Abstract:
1. A sustained release therapeutic nail varnish composition comprising: (a) an antifungal effective amount of an antifungal agent; (b) a keratolytic agent in an amount sufficient to increase and facilitate penetration of said antifungal agent into the nail; (c) greater than 3% (w/w) of a humectant to trap water; (d) water in an amount sufficient to hydrate the nail and thereby to further increase permeability of the nail in combination with said keratolytic agent; (e) a liquid nail lacquer component comprising a polymeric film forming agent and a volatile solvent, said agent selected to form a sustained release film upon application of said composition on a nail and evaporation of said volatile solvent; said sustained release film configured to trap water from said composition and maintain it in contact with said nail, said water and said humectant in combination still further facilitating penetration of said antifungal agent into the nail, and thereby enhancing therapeutic effectiveness of said antifungal agent.