Patent ID: 8134015
Filing Date: 2012-03-13
Classification: A61P,C07C,C07D

Abstract:
1. A compound represented by formula (I-1), or a pharmaceutically acceptable salt thereof: wherein A represents a five- to nine-membered unsaturated heterocyclic moiety, and selected from the group consisting of formula (IIb), formula (IIc), and formula (IId): wherein in formula (IIb) wherein in formula (IIc) wherein in formula (IId) wherein in formula (IIb), formula (IIc), and formula (IId) * represents a bond to —C(═O)—NH(—Z) R (I) a halogen atom; (II) C in (8) the mono- or di-C (III) C (IV) C (V) C (VI) aryl; (VII) aryloxy; (VIII) C (VIX) C (X) hydroxyl; (XI) nitro; (XII) cyano; (XIII) amino; (XIV) mono or di-C (XV) arylamino; (XVI) C (XVII) C (XVIII) C (XIX) C (XX) C (XXI) acyl; (XXII) carboxyl; (XXIII) carbamoyl; (XXIV) mono- or di-alkylcarbamoyl; (XXV) a heterocyclic group; (XXVI) alkyl- or aryl-sulfonyl; (XXVII) C (XXVIII) C Z represents group (A): wherein R (I) a halogen atom; (II) C (III) C (IV) C (V) C (VI) aryl; (VII) aryloxy; (VIII) C (VIX) C (X) hydroxyl; (XI) nitro; (XII) cyano; (XIII) amino; (XIV) mono- or di-C (XV) arylamino; (XVI) C (XVII) C (XVIII) C (XIX) C (XX) C (XXI) aryl; (XXII) carboxyl; (XXIII) carbamoyl; (XXIV) mono- or di-alkylcarbamoyl; (XXV) a heterocyclic group; (XXVI) alkyl- or aryl-sulfonyl; (XXVII) C (XXVIII) C