Patent ID: 8354100
Filing Date: 2013-01-15
Classification: A61K,A61L,A61P,C12N

Abstract:
1. A method for delivering a therapeutic agent to a target region comprising: providing a housing configured to retain a genetically altered chondrocyte and allow passage of the therapeutic agent, the housing comprising: (i) a cell chamber; (ii) an auxiliary fluid container to house an auxiliary fluid; and (iii) an expandable chamber; the auxiliary chamber being positioned between the cell chamber and the expandable chamber; providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express the therapeutic agent; delivering the housing and genetically altered chondrocyte into the target region, wherein the genetically altered chondrocyte expresses the therapeutic agent and the therapeutic agent is released from the housing in the target region, and wherein the target region is in an atypical chondrocyte environment.