Patent ID: 7166280
Filing Date: 2007-01-23
Classification: A61K,A61P,G01N

Abstract:
1. A method for the systemic, multi-tiered treatment of acute and chronic cardiomyopathy by delivering a formulation comprising one or more therapeutic growth factor proteins together with adult stem cells, the method comprising the steps of: a) selecting a patient displaying symptoms of acute or chronic cardiomyopathy; b) administrating at least one dose of an effective amount of a first therapeutic growth factor protein formulation comprising a growth factor protein being selected from the group consisting of FGF-1, FGF-2, VEGF, VEGFA, VEGF165, and mixtures thereof by inhalation therapy; c) following administration of at least one dose of an effective amount of a first therapeutic growth factor protein formulation, administrating at least one dose of an effective amount of adult stem cells; d) monitoring the effectiveness of administration of adult stem cells by echo-cardiogram and/or other clinical indictors; e) determining, based on monitoring the effectiveness of stem cell treatment by echo-cardiogram, whether an additional dose of stem cells is necessary or whether an additional dose of growth factor protein is indicted; f) depending on the results of the step e), administering a second dose of an effective amount of adult stem cells and or growth factor proteins; and g) if indicated, repeating steps b) through e) until there is a clinical indication of amelioration of amelioration of the symptoms of acute or chronic heart disease in the patient, or until there is contraindication to continued treatment.