Patent ID: 6355662
Filing Date: 2002-03-12
Classification: A61P,C07D

Abstract:
A compound of Formula (1.0.0): and pharmaceutically acceptable salts thereof, wherein:A is phenyl, substituted with 0 to 3 R10; or is a member selected from the group consisting of â€”A1â€”NHC(&boxH;O)NHâ€”A2â€”, â€”A1â€”NHC(&boxH;O)Oâ€”A2â€”, and â€”A1â€”NH(NCN)NHâ€”A2â€”, where A1 and A2 is each independently selected from the group consisting of hydrogen, provided that A1 and A2 may not both be hydrogen, pyridyl, and phenyl substituted with 0 to 3 R10; B is a group of partial Formula (1.1.2): â€ƒwhere the symbol â€œ*â€  indicates the point of attachment of the moiety represented by partial Formula (1.1.2) to the moiety â€œYâ€  in Formula (1.0.0); and the symbol â€œâ†’â€  indicates the point of attachment of the moiety represented by partial Formula (1.1.2) to the moiety â€œEâ€  in Formula (1.0.0); E is a single bond; â€”Oâ€”; â€”CH&boxH;CHâ€”; or a moiety of Formula (1.9.0): â€ƒwhere R1a is hydrogen when R1 has the meaning of a mono-valent substituent; and R1a is a single bond when R1 has the meaning of a di-valent substituent; X is â€”Oâ€”; â€”S(&boxH;O)qâ€”; or â€”N(R14)â€”; Y is â€”C(&boxH;O)â€”; â€”C(&boxH;S)â€”; â€”S(&boxH;O)2â€”; or â€”CH(Ra)â€”; m is an integer independently selected from 0, 1 and 2; n is an integer independently selected from 1 and 2; p is 1; q is an integer independently selected from 0 and 2; R is independently selected from the group consisting of -tetrazolyl; â€”C(&boxH;O)OR5; â€”C(&boxH;O)(CH2)kC(&boxH;O)OR5; â€”C(&boxH;O)NOâ€¢; â€”C(&boxH;O)NHâ€”S(&boxH;O)2R5; â€”S(&boxH;O)2â€”NR14R5; â€”C(&boxH;O)NHS(&boxH;O)2R6; and a moiety of partial Formulas (3.0.0): â€ƒwhere: k is an integer independently selected from 0, 1 and 2; R1 is independently selected from the group consisting of hydrogen; &boxH;O; &boxH;S; F; (C1-C6) alkyl substituted with 0 to 3 R10; (C2-C6) alkenyl substituted with 0 to 3 R10; phenyl substituted with 0 to 3 R12; and phenyl(C1-C4) alkyl wherein said phenyl and alkyl are substituted with 0 to 3 R12; C(&boxH;O)NR8R9; and C(&boxH;O)R8; R2 and R3 are each independently selected from the group consisting of hydrogen; (C1-C4) alkyl substituted with 0 to 3 R13; (C2-C6) alkenyl substituted with 0 to 3 R13; (C1-C4) alkoxycarbonylamino-(C1-C4)alkyl-; (C1-C4) alkylthio-(C1-C4)alkyl-; (C1-C4) alkylsulfonyl-(C1-C4)alkyl-; hydroxy(C1-C4) alkylthio-(C1-C4)alkyl-; (C1-C4) alkylcarbonylamino-(C1-C4)alkyl-; (C1-C4) alkylsulfonylamino-(C1-C4) alkyl-; and (C1-C4) alkylsulfonylaminocarbonyl-(C1-C4) alkyl-; provided that R2 and R3 are each defined as above; or they are taken together as defined below; or one of them is taken together with R4 as defined below, in which case the other has the meaning of hydrogen or methyl; R2 and R3 are taken together to form a spirocyclic (C3-C14) carbocyclic ring substituted with 0 to 3 R13; or R2 or R3 is taken together with R4 and the carbon and nitrogen atoms to which they are respectively attached to form a pyrrolidinyl group substituted with 0 to 3 R12; R5 is hydrogen; (C1-C4) alkyl; (C3-C6) cycloalkyl; or aryl; R6 is hydrogen; (C1-C4) alkyl; (CH2)râ€”(C3-C6)cycloalkyl; or (CH2)s-aryl; where: r and s are each independently an integer selected from 0, 1, and 2; R8 and R9 are each independently selected from the group consisting of hydrogen; (C1-C4) alkyl substituted with 0 to 3 R10; phenyl substituted with 0 to 3 R12; and phenyl-(C1-C4) alkyl wherein said phenyl and alkyl are substituted with 0 to 3 R12; R10 is independently selected from the group consisting of F; Cl; â€”C(&boxH;O)OR14; â€”OH; nitro; cyano; amino; di(C1-C4) alkylamino; (C1-C4) alkyl; (C1-C4) alkoxy; (C1-C4) alkylthio; and (C1-C4) alkyl and (C1-C4) alkoxy each substituted with 1 to 3 substituents independently selected from F and Cl; R12 when a substituent on a carbon atom, is independently selected from the group consisting of F; Cl; (C1-C4) alkyl; (C3-C6) cycloalkyl; (C1-C4) alkoxy; â€”C(&boxH;O)OR14; â€”OH; and (C1-C4) alkyl and (C1-C4) alkoxy each substituted with 1 to 3 substituents independently selected from F and Cl; or R12 when R12 is attached to a saturated carbon atom, may be &boxH;O or &boxH;S; or when R12 is attached to a sulfur atom, may be &boxH;O; or R12 when a substituent on a nitrogen atom, is independently selected from the group consisting of hydroxy; hydroxy(C1-C4) alkyl; (C1-C4) alkoxy; (C3-C6) cycloalkyl; (C1-C4) alkylcarbonyl; and phenyl; R13 is (C1-C4) alkoxy; and R14 is hydrogen; hydroxy; (C1-C4) alkyl; (C3-C6) cycloalkyl; or phenyl.