Patent ID: 6767887
Filing Date: 2004-07-27
Classification: A61K,A61P,C07K,Y10S

Abstract:
A peptide consisting essentially of SEQ ID NO:1 or SEQ ID NO:2SEQ ID NO:11â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ5â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ10His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln â€ƒâ€ƒâ€ƒâ€ƒ15â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ20â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ25Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ30Lys Asn Gly Xaa            SEQ ID NO:21â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ5â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ10His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln â€ƒâ€ƒâ€ƒâ€ƒ15â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ20â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ25Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu â€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒâ€ƒ30Lys Asn Gly Xaain which Xaa specifies one of the proteinogenic amino acids: Asp, Glu, Arg, His, Lys, Ala, Asn, Cys, Gln, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val or a non-proteinogenic amino acid, and wherein in positions 1, 2, 28, 29 or 30, independent of one another, amino acids are optionally part of the sequence, and the N-terminus is represented by NR1R2 in whichR1 denotes hydrogen, acetyl, trifluoroacetyl, adamantyl, Fmoc, benzyloxycarbonyl, Boc, Alloc, C1-C6 alkyl, C2-C8 alkenyl or C7-C9 aralkyl, R2 denotes hydrogen, acetyl, trifluoroacetyl, adamantyl, Fmoc, benzyloxycarbonyl, Boc, Alloc, C1-C6 alkyl, C2-C8 alkenyl or C7-C9 aralkyl, and the C-terminus is represented by COR3 in which R3 equals OR4 or NR4R5 in which R4 equals hydrogen or C1-C6 alkyl in which R5 equals hydrogen or C1-C6 alkyl, as well as physiologically tolerated salts and esters of the foregoing.