Patent ID: 7863451
Filing Date: 2011-01-04
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of Formula 1: or a pharmaceutically acceptable salt, thereof, wherein: each of R each of R R ProtG which comprises the alternative sequences of steps of: (1)(a) cyclizing a compound of Formula 2: and (b) optionally transforming one or more of the R into one or more of the corresponding R or: (2)(a) transforming one or more of the R into one or more of the corresponding R 1′ , R 2′ , R 3′ , and/or R 4′ substituents, respectively, of a compound of Formula 4: in one or more steps, and (b) cyclizing the transformed product of Formula 4, wherein, for both sequences of steps unless noted otherwise: each of R each of R R R ProtG wherein the cyclizing is performed under acidic condition in an aprotic solvent at a temperature at which the aprotic solvent refluxes or the cyclizing is performed under basic condition in an aprotic solvent at a temperature from about 0 to about 5° C.