Patent ID: 8981074
Filing Date: 2015-03-17
Classification: A61K,A61P

Abstract:
1. A lipid-modified double-stranded RNA comprising: an antisense strand having a nucleotide sequence complementary to a target sequence in a target gene, and a sense strand having a nucleotide sequence complementary to the antisense strand, the double-stranded RNA being blunt-ended on the 5′ end side of the sense strand, and being blunt-ended or having a dangling end on the 3′ end side of the sense strand, or alternatively the double-stranded RNA having dangling ends on both the 5′ and 3′ end sides of the sense strand, the sense strand having a lipid linked to at least one of the first to sixth nucleotides from the 5′ end via a linker, the lipid being a fatty acid having 6 to 50 carbon atoms, and the linker being represented by the structural formula: —NH—(CH 2 ) n1 — (L-4), wherein n1 is an integer of 1 to 40.