Patent ID: 6469031
Filing Date: 2002-10-22
Classification: A61K,C07D

Abstract:
A compound of the formula: wherein:R is hydrogen, hydroxy, oxo, halogen, C1-C10haloalkyl, C1-C10 alkyl, cyano, nitro, NR1R1, SR1, OR1, SO2R2, OCOR2, NR1COR2, COR2, NR1SO2R2, NR1CO2R1, phenyl; R1 is hydrogen, C1-C10 alkyl optionally substituted with 1 to 4 substituents selected from hydroxy, halogen, CO2H, CO2C1-C10 alkyl, SO2C1-C10 alkyl, C1-C10 alkoxy; or C3-C8 cycloalkyl, phenyl or naphthyl each optionally substituted with 1 to 4 substituents selected from halogen, nitro, oxo, C1-C10 alkyl, C1-C10 alkoxy, and C1-C10 alkylthio; R2 is R1 or NR1R1; R3 is hydrogen, C1-C10 alkyl, CO2R1, or Ar1 is pyridyl; m is 1, 2, or 3; n is independently in each instance 0, 1, or 2; X is C1-C4 alkyl optionally substituted with halogen; R4 is Oâ€”R1 or NR1R1, or a pharmaceutically acceptable salt or ester thereof.