Patent ID: 6159998
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A method of treating a subject suffering from a condition wherein the condition is selected from the group consisting of a condition treated by producing ocular vasoconstriction, migraine headache, hypertension, alcohol withdrawal, drug addiction, rheumatoid arthritis, presbyopia, ischemic pain, diarrhea, nasal congestion, and urinary incontinence which comprises administering to the subject an amount of a compound effective to treat the condition wherein the compound has the structure: wherein each of R.sub.1, R.sub.2 and R.sub.3 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl;wherein each of R.sub.4, R.sub.5 and R.sub.6 is independently --H, --F, --Cl, --Br, --I, --OH, --OR.sub.7, --OCOR.sub.7, --SR.sub.7, --N(R.sub.7).sub.2, --CN, --CO.sub.2 R.sub.7, --CON(R.sub.7).sub.2, or --COR.sub.7 ; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; C.sub.4 -C.sub.7 heterocycloalkyl or heteroaryl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each R.sub.7 is independently --H; --N(R.sub.10).sub.2, --NR.sub.10 COR.sub.10, --(CH.sub.2).sub.n OR.sub.10, --SO.sub.n R.sub.10, --SO.sub.n N(R.sub.10).sub.2, --(CH.sub.2).sub.n N(R.sub.10).sub.2, or --(CH.sub.2).sub.n NR.sub.10 COR.sub.10 ; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each n is independently an integer from 1 to 4;wherein each R.sub.8 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein R.sub.9 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; C.sub.4 -C.sub.7 heterocycloalkyl or heteroaryl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each R.sub.10 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; andwherein X is independently CH.sub.2, O, NH or S; ora pharmaceutically acceptable salt thereof.