Patent ID: 6479032
Filing Date: 2002-11-12
Classification: A61K,A61P,C07K

Abstract:
A synthetic, calcitonin receptor-binding compound having a molecular weight of less than about 10,000 daltons and being covalently linked to a radiometal chelator to form a reagent wherein:said reagent has a binding affinity for a calcitonin receptor equal to or greater than the binding affinity of radioiodinated native calcitonin for said receptor; and the chelator is selected from the group consisting of: a) C(pgp)sâ€”(aa)â€”C(pgp)s wherein (pgp)s is H or a thiol protecting group, and (aa) is any primary &agr;- or &bgr;-amino acid; whereineach R is independently H, CH3 or C2H5; each (pgp)s is independently a thiol protecting group or H; m, n and p are independently 2 or 3; A=linear or cyclic lower alkyl, aryl, heterocyclyl, a combination thereof, or a substituted derivative thereof; and whereineach R is independently H, CH3 or C2H5; m, n and p are independently 2 or 3; A=linear or cyclic lower alkyl, aryl, heterocyclyl, a combination thereof or a substituted derivative thereof; V=H or â€”CO-peptide; Râ€²=H or peptide; and wherein when V=H, Râ€²=peptide and when Râ€²=H, V=â€”CO-peptide.