Patent ID: 6184226
Filing Date: 2001-02-06
Classification: A61K,A61P,C07D

Abstract:
A method to specifically inhibit p-38 .alpha.-kinase which method comprises contacting p-38 .alpha.-kinase with a compound of the formula: ##STR10##or the pharmaceutically acceptable salts thereofwherein each R.sup.2 is independently selected from the group consisting of R.sup.4, halo, OR.sup.4, NR.sup.4.sub.2, SR.sup.4, --OOCR.sup.4, --NR.sup.4 OCR.sup.4, --COOR.sup.4, R.sup.4 CO, --CONR.sup.4.sub.2, --SO.sub.2 NR.sup.4.sub.2, CN, CF.sub.3, and NO.sub.2, wherein each R.sup.4 is independently H, or optionally substituted alkyl (1-6C), or optionally substituted arylalkyl (7-12C) and wherein two R.sup.2 taken together may form a fused ring of 5-7 members;m is an integer of 0-4;R.sup.1 is H, alkyl (1-6C) or arylalkyl optionally substituted on the aryl group with 1-3 substituents independently selected from alkyl (1-6C), halo, OR, NR.sub.2, SR, --OOCR, --NROCR, RCO, --COOR, --CONR.sub.2, --SO.sub.2 NR.sub.2, CN, CF.sub.3, and NO.sub.2, wherein each R is independently H or lower alkyl (1-4C);n is 0, 1 or 2;Ar is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR.sub.2, SR, --OOCR, --NROCR, RCO, --COOR, --CONR.sub.2, SO.sub.2 NR.sub.2, CN, CF.sub.3, and NO.sub.2, wherein each R is independently H or lower alkyl (1-4C); andR.sup.3 is a branched (5-7C) or cyclic alkyl group (5C or 7C) or is phenyl optionally substituted with 1-2 substituents which substituents are selected from the group consisting of alkyl (1-6C), halo, SR, --OOCR, --NROCR, RCO, --COOR, --CONR.sub.2, --SO.sub.2 NR.sub.2, CN, and CF.sub.3, wherein each R is independently H or lower alkyl (1-4C).