Patent ID: 7286941
Filing Date: 2007-10-23
Classification: G16B

Abstract:
1. A method for estimating the frequency of haplotypes and inferring haplotypes from genotypes for a set of individuals that comprises: (A) providing a set of genotypes obtained from at least two individuals comprising three or more polymorphic markers; (B) combining two or more markers, one or more markers and one or more loci, or two or more loci from the set of genotypes to give a new locus; (C) removing any haplotypes from the new locus that have a sufficiently low Maximum Likelihood Estimate (MLE) after at least one iteration of Expectation Maximum (EM) on the new locus; (D) repeating from step (B) one or more times, adding one or more loci or markers, until all the genotypes have been combined into a final locus; (F) running EM to convergence on the final locus to give the estimated frequency of haplotypes and inferred haplotypes from the set of genotypes; and (G) outputting the estimated frequency of haplotypes and inferred haplotypes.