Patent ID: 6191146
Filing Date: 2001-02-20
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR5##Wherein:A.sup.1 and A.sup.2 are independently Z--(CH.sub.2).sub.k --(NR').sub.m --;Z is pyridyl, and wherein the ring is substituted or unsubstituted by one or two C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sup.4, oxo, oxime, O--C.sub.1-4 alkyloxime, hydroxy, N(R.sup.3).sub.2, acylamino or aminoacyl groups;R' and R"" are independently hydrogen, C.sub.1-4 alkylC(O)R.sup.4, C.sub.1-4 alkyl or R' and R"" are benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sup.3).sub.2 ;k is independently an integer from 0 to 4;m is independently zero or one;Q is bicyclo[3.3.0]octanyl, xyleyl, benzophenonyl or 1,2,3,4-tetrahydronapthalyl; all of which are unsubstituted or substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, mono or di C.sub.1-4 alkylamino, (C.sub.1-4 alkyl).sub.2 --NC(O)--, --(CH.sub.2).sub.n --R.sup.2, --(CH.sub.2).sub.n --R.sup.3, --(CH.sub.2).sub.n --COR.sup.2 or --(CH.sub.2).sub.n --COR.sup.3 ;R.sup.2 is independently --OR.sup.3, --NR.sup.3.sub.2, --SR.sup.3 ;R.sup.3 is independently hydrogen, C.sub.1-4 alkyl or benzyl;R.sup.4 is independently --OR.sup.3, --N(R.sup.3).sub.2, --SR.sup.3 ; ann is independently an integer from 0 to 4;or a pharmaceutically acceptable salt thereof.