Patent ID: 6022974
Filing Date: 2000-02-08
Classification: C07D

Abstract:
A process for the production of 2-chloro-5-chloromethyl-pyridine of formula: ##STR12## comprising, in a first step, reacting 6-hydroxynicotinic acid of formula: ##STR13## with an acid chloride to 6-hydroxynicotinoyl chloride of formula: ##STR14## in a second step, catalytically hydrogenating the 6-hydroxynicotinoyl chloride of formula III with hydrogen to 6-hydroxynicotinic acid aldehyde of formula: ##STR15## in a third step, catalytically hydrogenating the 6-hydroxynicotinic acid aldehyde of formula IV with hydrogen to 2-hydroxy-5-hydroxymethylpyridine of formula: ##STR16## and, in a fourth step, chlorinating the 2-hydroxy-5-hydroxymethylpyridine of formula V to the 2-chloro-5-chloromethyl-pyridine of formula I.