Patent ID: 6262056
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A benzothiophene compound of formula (1): ##STR44##where:Z is: --CO--, --CH(OR.sub.6)--, --C(NOR.sub.7)--;R.sub.1 is: H, low molecular weight alkyl, halogen, or --OR.sub.6 ;R.sub.2 and R.sub.3 are independent and stand for: H, C.sub.1 -C.sub.6 alkyl, halogen, --OR.sub.8, nitro, cyano, NR.sub.9 R.sub.10 ; --COR.sub.8 ; CO.sub.2 R.sub.8 ; --SO.sub.2 NR.sub.9 R.sub.10 ; --SO.sub.2 R.sub.8 ; SR.sub.8 ; --CONR.sub.9 R.sub.10 ;R.sub.4 and R.sub.5 are the same or different and each stands for: H, low molecular weight alkyl, halogen, haloalkyl, --OR.sub.8, nitro, NR.sub.8 R.sub.10 ; --COR.sub.8 ; CO.sub.2 R.sub.8 ; --SO.sub.2 NR.sub.8 R.sub.10 ; --SO.sub.2 R.sub.8 ; SR.sub.8, cyano; --CONR.sub.9 R.sub.10 or R.sub.4 and R.sub.5 may form together a benzene ring fused to the phenyl ring;--R.sub.6 is: H, C.sub.1 -C.sub.6 alkyl, CO.sub.2 R.sub.8, --C(O)NR.sub.9 R.sub.10, naphthyl or phenyl optionally substituted by one or more substituents selected from among the following: H, haloalkyl, alkyl, halogen, low molecular weight alkoxy, methylenedioxy, nitro, cyano;R.sub.7 is: H or C.sub.1 -C.sub.6 alkyl; --R.sub.8 is: H, low molecular weight alkyl or phenyl; --R.sub.9 and R.sub.10 are independent and stand for: H, low molecular weight alkyl or phenyl, or a salt, a hydrate, a geometric isomer, an optical isomer, or a polymorph thereof.