Patent ID: 6063929
Filing Date: 2000-05-16
Classification: C07D

Abstract:
A method to prepare a 4,5-dihydro-2-(3-pyridyl)-thiazole, comprising the steps of:a) heating a mixture of a compound of the formula: ##STR6## wherein X is chloro, bromo, iodo, thiol, or hydroxy;Y.sub.1 and Y.sub.2 and independently hydrogen or alkyl;R.sub.2, R.sub.4, R.sub.5, and R.sub.6 are independently hydrogen, halo, alkyl, alkenyl, alkynyl, cycloalkyl, cycloaklylalkyl, alkylthioalkyl, bis(alkylthio)alkyl, cyano, fluorinated methyl, chlorofluorinated methyl, chlorinated methyl, or ##STR7## wherein Z.sub.1 is O, S, or NR.sub.7 wherein R.sub.7 is alkyl and Z.sub.2 is alkoxy, alkenoxy, alkynoxy, alkylthio, pyrazolyl, haloalkoxy, cyanoalkoxy, chloro or --NHR.sub.8 wherein R.sub.8 is lower alkyl;and P.sub.2 S.sub.5 in a solvent at reflux; andb) degassing the mixture while heating.