Patent ID: 7977331
Filing Date: 2011-07-12
Classification: A61P,C07D

Abstract:
1. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein is N—C═C, G Q is —(CH (wherein c and d are each independently 0 or an integer of 1 to 4, Q (1′) —O—, (2′) —NH—, (3′) —S—, (4′) —CO—, (5′) —SO—, or (6′) —SO ring A is benzene, G R (1) a carboxyl group, (2) a carboxylic acid equivalent, (3) —CONR (wherein R (1′) a hydrogen atom, (2′) a C (3′) a C (4′) a C (5′) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group E (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), or (6′) a C (4) —COOR (wherein R R (1) a hydrogen atom, (2) a group selected from the following group E, (3) a C (4) a C {wherein L (1′) a bond, (2′) C (3′) C (4′) —(CH (5′) —(CH (6′) —(CH (7′) —(CH (8′) —(CH (9′) —(CH (10′) —(CH (11′) —(CH (12′) —(CH (13′) —(CH (14′) —(CH (wherein u, v, u1 and v1 are each independently 0 or an integer of 1 to 6, R (1″) a hydrogen atom, (2″) a group selected from the following group C, (3″) —COR (4″) —CONR (5″) —COOR (6″) —SO (wherein R R (1″) a hydrogen atom, (2″) a group selected from the following group C, (3″) —COR (4″) —SO (wherein R L (1′) —CHR (2′) —NR (wherein R ring D (1′) a C (2′) a C (3′) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group E (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom)}, R (1) a hydrogen atom, (2) a halogen atom, (3) a C (4) a carboxyl group, (5) a cyano group, (6) a nitro group, (7) a C (8) —OR (wherein R (9) —NR (wherein R (10) —COOR (wherein R (11) —CONR (wherein R (12) —SO (wherein R (13) —NHCOR (wherein R (14) —C(═NR (wherein R (15) —P(═O)(OR (wherein R (16) —P(═O)(OR (wherein R (17) —CONHCO—R (wherein R (18) —CONHSO (wherein R (19) —SO (wherein R (20) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), R (1) a halogen atom, (2) a C (3) —OR (wherein R (4) —NR (wherein R (5) a C (6) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), a is 0, 1 or 2, R (1) a hydrogen atom, (2) a halogen atom, (3) a C (4) —OR (wherein R (5) —NR (wherein R ring Cy is (1) a C (2) a C (3) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), X is (1) a group selected from the following group D, (2) a C (3) wherein ring B is (1′) a C (2′) a C (3′) a heterocyclic group comprising 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom, each Z is independently (1′) a group selected from the following group D, (2′) a C (3′) a C (4′) a C (5′) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the following group D (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom) or (6′) a heterocycle C (wherein said heterocycle C w is an integer of 1 to 3, Y is (a) C (b) C (c) —Y (wherein m and n are each independently 0 or an integer of 1 to 6, Y (1′) a bond, (2′) —O—, (3′) —NR (4′) —S—, (5′) —CO—, (6′) —SO—, (7′) —SO (8′) —CO (9′) —OCO—, (10′) —CONR (11′) —NR (12′) —SO (13′) —NR (14′) —NR (15′) —OCONR (16′) —NR (17′) —CR (18′) —CH═CH— (wherein R (1″) a hydrogen atom, (2″) a group selected from the following group C, (3″) —COOR (4″) —CONR (5″) —COR (6″) —SO (wherein R R (1″) a hydrogen atom, (2″) a group selected from the following group C, (3″) —COR (4″) —SO R (1″) a hydrogen atom, (2″) a carboxyl group, (3″) a group selected from group F, (4″) —OR (5″) —NHR (wherein R group A: (1) a halogen atom, (2) a C (3) —OR (4) —SR (5) —NR (6) —COOR (7) —CONR (8) —SO (9) —SO (10) —NHCOR (11) —NHSO (wherein R group B: (1) a halogen atom, (2) a cyano group, (3) a nitro group, (4) a C (5) a halogenated C (6) —(CH (7) —(CH (8) —(CH (9) —(CH (10) —(CH (11) —(CH (12) —(CH (13) —(CH (14) —(CH (15) —(CH (16) —(CH (17) —(CH (18) —(CH (19) —(CH (wherein R group C: (1) a C (2) a C (3) a C (4) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the aforementioned group B and (5) a heterocycle C group D: (a) a hydrogen atom, (b) a halogen atom, (c) a cyano group, (d) a nitro group, (e) a C (f) —(CH wherein R (1) a hydrogen atom, (2) a group selected from the following group F, (3) a C (4) a C hereinafter each t is independently 0 or an integer of 1 to 6, (g) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, q is 0, 1, 2 or 3, (h) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (i) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (j) —(CH wherein R (1) a hydrogen atom, (2) a hydroxyl group, (3) a group selected from the following group F or (4) a C (k) —(CH wherein R (l) —(CH wherein R (1) a hydrogen atom, (2) a C (3) a C R (1) an amino group, (2) a C (3) a group selected from the following group F, (m) —(CH wherein R (1) a hydrogen atom, (2) a C (3) a C R (1) a hydrogen atom or (2) a group selected from the following group F, (n) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (o) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (p) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, R (q) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (r) —(CH wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (s) —(CH wherein R (1) a hydrogen atom, (2) a hydroxyl group, (3) a C (4) C (t) —(CH wherein R (1) an amino group, (2) a C (3) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the aforementioned group B, p is 0 or an integer of 1 to 6, and (u) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the aforementioned group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom) group E: (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) —OR wherein R (1) a hydrogen atom, (2) a group selected from the following group F, (3) a C (4) a C (e) —S(O) wherein R (1) a hydrogen atom or (2) a group selected from the following group F, q is 0, 1, 2 or 3, (f) —NR wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (g) —COOR wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (h) —CONR wherein R (1) a hydrogen atom, (2) a hydroxyl group, (3) a group selected from the following group F or (4) a C (i) —COR wherein R (j) —NR wherein R (1) a hydrogen atom, (2) a C (3) a C R (1) an amino group, (2) a C (3) a group selected from the following group F, (k) —NR wherein R (1) a hydrogen atom, (2) a C (3) a C R (1) a hydrogen atom or (2) a group selected from the following group F, (l) —SO wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (m) —CONR wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (n) —SO wherein R (1) a hydrogen atom or (2) a group selected from the following group F, R (o) —NR wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (p) —NR wherein R (1) a hydrogen atom or (2) a group selected from the following group F, (q) a C (r) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the aforementioned group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), (s) a C (t) a heterocycle ylidene group optionally substituted by 1 to 5 substituents selected from the aforementioned group B (wherein said heterocycle ylidene group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), when group E is a substituent on a C (u) a C (v) C group F: (1) a C (2) a C (3) a heterocyclic group optionally substituted by 1 to 5 substituents selected from the aforementioned group B (wherein said heterocyclic group comprises 1 to 4 heteroatoms selected from oxygen atom, nitrogen atom and sulfur atom), (4) a C (5) a C (6) a heterocycle C (wherein said heterocycle C (7) a C