Patent ID: 6087381
Filing Date: 2000-07-11
Classification: A61P,C07D

Abstract:
A compound of Formula IA ##STR46## wherein R.sup.1 is selected from hydrido, lower alkyl, lower alkynyl, lower cycloalkylalkylene, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower thioalkyl, lower alkylthioalkylene, lower alkylaminoalkylene, and lower heterocyclylalkylene; andQ is selected from lower alkylene, lower alkenylene, ##STR47## represents a four to eight membered ring heterocyclylidenyl comprising one or more heteroatoms selected from oxygen, sulfur and nitrogen; andwherein n is an integer from 1 to 7; andR.sup.2 is aryl optionally substituted with one or more radicals independently selected from halo, lower alkyl, lower alkoxy, lower aryloxy, lower aralkoxy, amino, hydroxyl, nitro, cyano, lower haloalkyl, lower alkylamino, and lower alkynylamino; andR.sup.3 is pyridyl optionally substituted with one or more radicals independently selected from halo, lower alkyl, cyano, phenethyl, benzyl, benzyloxy, benzylthio, benzylamino, phenethylamino, aminocarbonyl, lower alkylcarbonylamino, hydroxyl, amino, lower alkylamino, lower aminoalkyl, and phenylamino; andR.sup.4 is selected from hydrido, lower alkyl, phenyl, lower haloalkyl, 5-10 membered heterocyclyl, lower alkylamino, lower alkynylamino, phenylamino, lower cycloalkyl, lower alkenyl, lower cycloalkenyl, lower alkoxy, lower heterocyclylaminoalkyl, and lower heterocyclylalkylamino; wherein the phenyl, 5-10 membered heteroaryl, lower cycloalkyl and lower cycloalkenyl groups are optionally substituted with one or more radicals independently selected from halo, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, phenoxy, lower aralkoxy, lower haloalkyl, amino, hydroxyl, cyano and lower alkylamino; and wherein the amino radicals of lower heterocyclyl alkylamino and lower heterocyclylaminoalkyl are optionally substituted with one or more lower alkyl; andR.sup.6 is selected from hydrido, lower alkyl, lower alkenyl, and lower alkynyl, andR.sup.7 and R.sup.8 are independently selected from hydrido, lower lower alkyl, lower alkenyl, and lower alkynyl, or together form a carbocyclic or heterocyclic ring having three to eight members; andR.sup.9 is selected from hydrido, lower alkyl, lower alkenyl, and lower alkynyl; andR.sup.10 is selected from hydrido, lower alkyl, lower alkenyl, and lower alkynyl; andR.sup.11 is selected from hydrido, lower alkyl, lower alkenyl, and lower alkynyl; andR.sup.12 is selected from hydrido and lower alkyl; or a pharmaceutically acceptable salt thereof.