Patent ID: 7015325
Filing Date: 2006-03-21
Classification: A61P,C07D

Abstract:
1. A compound of the formula I in which M is a central building block of the formula below n is 1 or 2, U1 and U2 are identical or different and are methylene [—CH A1 is A3-B1-A5-, A2 is A4-B2-A6-, A3 and A4 are identical or different and are —C(O)—, —O(C)—O—, —C(O)—NH—, —NH—C(O)—, —O—C(O)—NH—, —NH—C(O)—O—, —NH—C(O)—NH—, —O—C(O)—O—, —O—(CH r is 1, 2, 3 or 4, m is 1, 2, 3 or 4, A5 and A6 are identical or different and are —C(O)—, —C(O)—NH—, —NH—C(O)—, —O—C(O)—NH—, —NH—C(O)—O—, —NH—C(O)—NH— or —O—C(O)—O—, B1 and B2 are identical or different and are 1–4C-alkylene, 1–4-cyclohexylene, 1,3-cyclohexylene, 1,4-phenylene, 1,3-phenylene, 1,4-piperazinylene or 1,4-piperidinylene, K1 is -B3-X1, -B3-Y1 or B3-Z1-B5-X1, K2 is -B4-X2, -B4-Y2 or B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1–4C-alkylene, B5 and B6 are identical or different and are a bond or 1–2C-alkylene, X1 and X2 are identical and are amino, aminocarbonyl or amidino, Y1 and Y2 are imidazol-1-yl, Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3-cyclohexylene or 1,4-cyclohexylene, and where on the direct route between the terminal nitrogen atoms 20 to 45 bonds have to be present, or a hydrate, solvate, salt, hydrate of a salt or solvate of a salt thereof, or an N-oxide of the nitrogen-containing heteroaryls, heteroarylenes and heterocycloalkylenes, or a hydrate, solvate, salt, hydrate of a salt or solvate of a salt thereof, where all those compounds are excluded in which, owing to the meaning of the variables A3, A4, A5, A6, B1, B2, B3, B4, Z1, Z2, X1 or X2, there would be a direct linkage of two heteroatoms.