Patent ID: 6291685
Filing Date: 2001-09-18
Classification: C07D

Abstract:
A process for the preparation of bicyclic compound of the formula ##STR17##comprising cyclocarbonylating a monocyclic compound of the formula ##STR18##wherein Y is halogen or --OR; and--OR is an aryloxy group or a group of formulae --O--(CO)--R', --O--(CO)--O--R"" or --O--(PO)--(OR"").sub.2, wherein R' is alkyl perfluoro-C.sub.1-20 -alkyl, aryl, R"" is alkyl, aryl or benzyl;by reacting, in an organic solvent medium containing a base and a carboxylic acid anhydride, said monocyclic compound with carbon monoxide in the presence of a carbonylation catalyst capable of complexing with carbon monoxide, said cyclocarbonylation reaction being carried out by introducing carbon monoxide gas into the reaction medium to form the carboxylic acid ester of the compound of formula I and thereafter saponifying said ester formed by said carbonylation reaction by treating said ester product in said reaction medium with a base at a pH of from 8 to 14 to form said bicyclic compound.