Patent ID: 8362274
Filing Date: 2013-01-29
Classification: A61P,C07D,C07H

Abstract:
1. An arylalkylamine compound represented by the formula [I-e]: the symbols in the formula represent the following meanings: Ar: represents naphthyl optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, cyano, halo-lower alkyl, lower alkyl, lower alkoxy and lower alkylthio; R halogen, cyano, nitro oxo group, hydroxy, carboxy, lower alkyl optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkoxy and halo-lower alkoxy, lower alkoxy optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy and hydroxyl, amino optionally mono- or di-substituted by a group selected from the group consisting of lower alkyl and halo-lower alkyl, 5 to 6-membered monocyclic heterocyclic group selected from the group consisting of tetrazole, pyridazinyl, and partially saturated cyclic group thereof, which is optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, and acyl, phenyl optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, and acyl, and acyl; n: is an integer of 2; X: represents single bonding arm; in the above-mentioned respective definitions of the X, the bonding arm described at the left end represents a bond with R or a pharmaceutically acceptable salt thereof.