Patent ID: 8445484
Filing Date: 2013-05-21
Classification: A61P,C07D

Abstract:
1. A compounds of formula (I) wherein: R1 is —CH(R)COR5; R is an α-amino acid side chain; R2 is H, alkyl, aryl, alkylaryl; R3 and R4 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, alkylaryl, aryl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, and —CH(α-amino acid side chain)CH R3 and R4 together with the nitrogen atom to which they are connected can form a ring, selected from the group consisting of piperidine, 4-hydroxyethyl-piperazine, 4-methyl-piperazine, 4-carboethoxy-piperazine, 4-phenylethyl-piperazine, 4-benzyl-piperazine, and morpholine; R5 is selected from the group consisting of -Oalkyl, -Oaryl, -NHalkyl, NHaryl, and amino acid; comprising all the possible combination of stereoisomers. the term “amino acid” includes every natural α-amino acids of the L or D series having as “side chain”: —H for glycine; —CH3 for alanine; —CH(CH