Patent ID: 8858917
Filing Date: 2014-10-14
Classification: A61K,A61P

Abstract:
1. A method for decreasing aerosolization of droplets of lung fluid from an upper airway comprising administering a dry powder formulation for reducing aerosolization of droplets of lung fluid from the upper airway by increasing the critical air speed required for aerosolization, wherein an active agent to decrease aerosolization consists of microparticles less than 10 microns in diameter in an effective amount for pulmonary administration by a dry powder inhaler or metered dose inhaler, the microparticles comprising a polymeric surface modifying agent delivered to the fluid lining of the lung in an effective amount and molecular weight to increase surface tension, surface elasticity and viscosity of normal lung mucous lining fluid, thereby decreasing droplet formation by the fluid lining of the lung by up to 50% as compared to the droplet formation by the microparticles not including the surface modifying agent, wherein the surface modifying agent is selected from the group consisting of proteins, polysaccharides and synthetic polymers.