Patent ID: 8877242
Filing Date: 2014-11-04
Classification: A61K,A61L,A61P

Abstract:
1. A medical device comprising: a substrate and a biocompatible coating deposited on at least a fraction of said substrate, wherein said biocompatible coating comprises a matrix composition having an ordered alternating multilayer structure, said matrix composition comprising: a. a biodegradable polymer in non-covalent association with a first lipid having a polar group, wherein said first lipid comprises a sterol; b. a second lipid comprising at least one phosphatidylcholine having hydrocarbon chains of at least 14 carbons; c. at least one pharmaceutical active agent; wherein the matrix composition is lipid saturated and said ordered alternating multilayer structure comprises said biodegradable polymer and said lipids, wherein each biodegradable polymer layer is separated by a layer of lipids; wherein the weight ratio of total lipids to said biodegradable polymer is between 1.5:1 and 9:1 inclusive; and wherein the release time of 90% of the active ingredient from the matrix composition is between 1 week and 6 months, wherein at least 50% of said pharmaceutical active agent is released from the composition at zero-order kinetics when said matrix is maintained in an aqueous environment.