Patent ID: 7476669
Filing Date: 2009-01-13
Classification: A61K,A61P,C07D,C07K,Y02A

Abstract:
1. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent, wherein the cytotoxic agent is one or more taxanes covalently bonded to a cell binding agent through a linking group, wherein at least one of said taxanes is a compound represented by formula (I): wherein: R R R R R R Z is H or SR, wherein R and R X is linear alkyl having 1 to 10 carbon atoms or branched alkyl having 3 to 10 carbon atoms, and n is an integer of 1 to 10; and R wherein the target cells express a marker that binds to the cell binding agent, and wherein the target cells are human cancer cells.