Patent ID: 8377967
Filing Date: 2013-02-19
Classification: A61P,C07D

Abstract:
1. A piperidine derivative, or salt or hydrate thereof that is pharmaceutically acceptable, wherein the piperidine derivative is represented by the following general formula (I): wherein R (a) a cyano, (b) acrylic acid, an alkyl ester of acrylic acid, or a hydroxyalkylamide of acrylic acid, (c) a ureido, (d) an alkenyl, (e) an aminoalkyl which may be substituted with an alkylcarbonyl or an aminocarbonyl, (f) a carbonylalkyl substituted with a hydroxy, an alkoxy or a hydroxyalkylamino, (g) a carbonyl substituted with a hydroxy, a morpholino, an alkoxy, a hydroxyalkylaminoalkoxy or cyclohexyloxycarbonyloxyalkoxy, (h) a carbonylamino substituted with an alkyl or an alkoxy, (i) an aminocarbonyl which may be substituted with one or two substituents selected from an amino, a hydroxy, an alkoxy, an alkenyl, and an alkyl (which may be substituted with a halogen, a thiol, a piperidino, an amino, an alkoxy, an alkoxycarbonyl, an aminocarbonyl, or one or two hydroxys); R (j) acrylic acid, an alkylester of acrylic acid, or a hydroxyalkylamide of acrylic acid, (k) an alkyl substituted with a hydroxy or a piperidino, (l) a carbonylalkyl substituted with a hydroxy, an alkoxy (which may be substituted with a cyclohexyloxycarbonyloxy), a piperidino, or a hydroxyalkylamino, (m) a carbonyl substituted with a hydroxy, an alkoxy, or a hydroxyalkylamino, (n) a carbonylalkoxy substituted with a hydroxy or an alkoxy, (o) a carbonylalkylsulfanyl substituted with a hydroxy or an alkoxy, (p) an alkoxy, (q) a halogen; and R (r) an alkyl which may be substituted with a carboxy, a cyano, a pyrrolidyl, a piperidino, an alkoxy, an alkylsulfanyl, or one or two hydroxys, (s) a carbonyl substituted with an alkyl or alkoxy, (t) a carbonylalkoxyalkyl substituted with a hydroxy or an alkoxy, (u) a carbonylalkyl substituted with an alkyl, an alkoxy, or an alkylphenyl, (v) an aminoalkyl substituted with an aminocarbonyl or an alkanesulfonyl, wherein one of the above R