Patent ID: 8808669
Filing Date: 2014-08-19
Classification: A61K,A61P

Abstract:
1. A gastroretentive, extended release composition for oral administration comprising: a. a graft copolymer of formula 1 which exhibits pH dependent behavior and capable of swelling at acidic pH, represented by  wherein the said graft copolymer comprises: I. a backbone having the formula [A II. a graft which is a polymer of a vinyl pyridine monomer (D) and ‘w’ is a weight percent of the total weight of said graft copolymer such that ‘w’ is 22-52%; b. a gellable polymer, said gellable polymer selected from the group consisting of cellulosic polymers and polyalkene oxide; c. a therapeutically active agent; d. a gas generating system, said gas generating system comprising a gas generating agent and a carboxyl compound, said gas generating agent selected from the group consisting of alkali carbonates and bicarbonates; and e. pharmaceutically acceptable ingredients.