Patent ID: 9195949
Filing Date: 2015-11-24
Classification: G06N,G06Q,G16B,G16H

Abstract:
1. A method of decreasing a risk of disease in a person x, comprising: (A) obtaining a single nucleotide polymorphism (SNP) transductive model Mx suitable for use in data analysis, wherein the risk of disease specific to the person x is represented as input vector x, which comprises a plurality of variable features in relation to the risk of disease for which there is a global dataset D of samples also having the same variable features relating to the risk of disease as input vector x, and for which an outcome is known, (B) optimizing the transductive model by (C) creating a SNP profile of sample x from patient x and a corresponding gene profile by mapping the SNPs from a final set Vx into genes; (D) determining the risk of disease specific to the patient x using the optimized transductive model Mx by: (E) modifying variable features Vx in the patient x to be closer to Kx values associated with an improved outcome relative to a prognostic outcome y determined for the patient x so as to improve the prognostic outcome of the patient x; (F) repeating elements a) through h) to determine an improved prognostic outcome using re-optimized transductive model Mx; and (G) creating a scenario for treatment/drug design that includes a set of SNPs/genes and required changes for the person x to match in future, average profiles of control samples from Dx in order to decrease the risk of disease.