Patent ID: 7186843
Filing Date: 2007-03-06
Classification: A61P,C07D

Abstract:
1. A compound represented by the following formula, or a salt or hydrate thereof wherein R wherein the heteroaryl group is a five-membered ring or a six-membered ring and contains from 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, wherein said aryl group and heteroaryl group may have one or more substituents selected from the group consisting of a halogen atom, a hydroxy group, a thiol group, an amino group, a nitro group, a cyano group, a carboxy group, a carbamoyl group, a phenyl group, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms, an alkoxycarbonyl group having from 2 to 6 carbon atoms, an acyl group having from 2 to 5 carbon atoms and a heteroaryl group which is a five-membered ring or a six-membered ring and contains from 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, wherein the alkyl group, alkoxy group, alkylthio group, alkoxycarbonyl group, acyl group, phenyl group and heteroaryl group may have one or more substituents selected from the group consisting of a halogen atom, a hydroxy group, an alkoxy group having from 1 to 6 carbon atoms and an alkylthio group having from 1 to 6 carbon atoms, and the amino group may have one or two substituents selected from the group consisting of a formyl group, an alkyl group having from 1 to 6 carbon atoms, an acyl group having from 2 to 5 carbon atoms and an alkoxycarbonyl group having from 2 to 5 carbon atoms; R R wherein the alkyl group represented by R R wherein the alkyl group may have one or more substituents selected from the group consisting of a hydroxy group, a halogen atom and an alkoxy group having from 1 to 6 carbon atoms; R Q′ represents a protective group of an amino group; wherein the protective group of an amino group is a protective group selected from the group consisting of a tert-butoxycarbonyl group, 2,2,2-trichloroethoxycarbonyl group, benzyloxycarbonyl group, para-methoxybenzyloxycarbonyl group, para-nitrobenzyloxycarbonyl group, acetyl group, methoxyacetyl group, trifluoroacetyl group, chloroacetyl group, pivaloyl group, formyl group, benzoyl group, tert-butyl group, benzyl group, para-nitrobenzyl group, para-methoxybenzyl group, triphenylmethyl group, methoxymethyl group, tert-butoxymethyl group, tetrahydropyranyl group, 2,2,2-trichloroethoxymethyl group, trimethylsilyl group, isopropyldimethylsilyl group, tert-butyldimethylsilyl group, tribenzylsilyl group, and tert-butyldiphenylsilyl group.