Patent ID: 9084808
Filing Date: 2015-07-21
Classification: A61K,C12N

Abstract:
1. A method for inhibiting Hepatitis B Virus (HBV) replication in a patient, the method comprising the steps of: (a) administering to said patient a composition comprising a modified double-stranded RNA (dsRNA) or modified small interfering RNA (siRNA) in an amount effective to mediate RNA interference and to inhibit HBV replication, wherein the modified dsRNA or modified siRNA comprises a first strand and a second strand, wherein the first and second strand are each no more than about 30 ribonucleotides in length and wherein the first or second strand targets HBV; and wherein the modified dsRNA or modified siRNA is cholesterol-labeled, and (b) administering to said patient a cholesterol-lowering drug, wherein steps (a) and (b) can be performed simultaneously or in any order, and (c) wherein the cholesterol-lowering drug reduces the level of competing cholesterol in the serum, allowing more efficient uptake of the cholesterol-labeled modified dsRNA or modified siRNA by hepatocytes.