Patent ID: 6826487
Filing Date: 2004-11-30
Classification: B01J,C40B

Abstract:
A method, comprising:(A) defining a first experimental space comprising factors of at least two mixtures with at least one common factor; (B) determining a number of experiments for a second experimental space by the relationship V+&Product;i=13&it;â€ƒ&it;niÃ—I3+[&Sum;i=13&it;â€ƒ&it;1ni&it;&Product;i=13&it;â€ƒ&it;ni]Ã—I2;for a ternary system (T=3) or an algorithm for a succeeding T-nary system, determined from a previous term by: (a) adding an additional term which contains an additional summation, incremented over a next index from a starting point one unit higher than the first summation; (b) decrementing the subscript on I; and (c) adding a value of n, indexed by the next index, to the inverse term;(C) deleting duplicate factor combinations from the first determined experimental space to define a second experimental space wvith a number of experiments determined in (B); and (D) conducting a combinatorial high throughput screening (CHTS) experiment on said second experimental space, comprising an iteration of steps of simultaneously reacting a multiplicity of tagged reactants and identifying a multiplicity of tagged products of the reaction and evaluating said identified products after completion of a single or repeated iteration to select a best case set of factors from said second experimental space.