Patent ID: 6387937
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of the formula where W is n is 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is â€”Sâ€”; R1 is hydrogen, C1 to C8 alkyl, substituted C1 to C8 alkyl substituted with one hydroxy, C3 to C8 alkenyl, C3 to C8 alkynyl, aryl, C1 to C3 alkylaryl, or â€”Qâ€”R4; R2 and R3 are each independently hydrogen, C1 to C6 alkyl, aryl, or C1 to C3 alkylaryl; R4 is cyano, trifluoromethyl, â€”COR9, â€”CO2R9, â€”CONR9R10, â€”OR9, â€”SO2NR9R10, or â€”S(O)qR9; R9 and R10 are each independently hydrogen, C1 to C8 alkyl, C1 to C3 alkylaryl, aryl, or R9 and R10 may together be taken to form a three- to seven-membered alkyl ring or a three- to seven-membered heteroalkyl ring having 1 heteroatom of O; Q is C1 to C3 alkyl; R11 is hydrogen, â€”OR12, or â€”NHCOR12; R12 is hydrogen, C1 to C6 alkyl, aryl, or C1 to C3 alkyl-aryl; q is 0, 1, or 2; a first chiral carbon is designated by an asterisk; a second chiral carbon is designated by #; the above alkyl, alkenyl, alkynyl, and alkylene moieties of other groups are linear, branched, cyclic, or be linear or branched and containing cyclic moieties; and the above aryl groups and the aryl moieties of the above alkyl-aryl groups are independently selected from phenyl and substituted phenyl, wherein said substituted phenyl may be substituted with one nitro or one to three groups selected from C1 to C4 alkyl, halogen, hydroxy, cyano, carboxamido, and C1 to C4 alkoxy, and the pharmaceutically acceptable salts thereof.