Patent ID: 6608218
Filing Date: 2003-08-19
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: wherein R1 and R2 are independently hydrogen, halo, cyano, nitro, lower alkylthio, perfluoro loweralkylthio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R3 is lower alkyl having from 2 to 4 carbon atoms or a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur; R4 is â€”C(O)NHR5; R5 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, â€”(CH2)nâ€”C(O)â€”OR7, â€”C(O)â€”(CH2)nâ€”C(O)â€”OR8; R7 and R8 are independently hydrogen or lower alkyl; X is oxygen, sulfur, sulfonyl or carbonyl; and the * indicates an asymmetric carbon atom; or a pharmaceutically acceptable salt thereof.