Patent ID: 6121025
Filing Date: 2000-09-19
Classification: C12P,Y10S

Abstract:
A process for producing optically active 3-quinuclidinol or a salt thereof, wherein a racemic 3-quinuclidinol ester represented by the general formula (I): ##STR4## wherein R represents a straight-chain or branched alkyl group containing 1 to 10 carbon atoms, and (H+) represents that said ester may be in the form of a salt formed with a mineral acid or an organic acid, is reacted with a microorganism having the ability to asymmetrically hydrolyze said ester linkage, wherein said microorganism is selected from the group consisting of Rhizopus sp., Aspergillus oryzae, Aspergillus melleus, Aspergillus sojae, Aspergillus niger, Aspergillus saitoi, Candida antarctica, and Pseudomonas sp. MR2301 strain FERM BP4870, a culture of said microorganism, a treated material from said microorganism, or an enzyme produced by said microorganism, wherein said treated material from said microorganism is selected from the group consisting of the microorganism treated with acetone, the microorganism treated with toluene, the lyophilized microorganism, the disrupted microorganism, a cell-free extract from the microorganism, and a crude enzyme solution extracted from the microorganism, and wherein said enzyme is a lipase, protease or esterase.