Patent ID: 6225504
Filing Date: 2001-05-01
Classification: B01J,C07H,Y02P

Abstract:
A process for the preparation of the phosphanes of formulaAr.sup.1.sub.3-x P[Ar.sup.2 (OZ).sub.y].sub.x Iwherein Ar.sup.1 and Ar.sup.2 are individually aromatic rings, each having 6 to 20 carbon atoms, or heteroaromatic rings, each having 4 to 9 carbon atoms, each unsubstituted or substituted with at least one member of the group consisting of halogen, carboxyl, --OH, alkyl of 1 to 6 carbon atoms, phenyl and naphthyl, Ar.sup.1 has one valence and R.sup.2 has y+1 valences, x is an integer of 1, 2 or 3, y is 1 or 2, Z is a residue of a carbohydrate selected from the group consisting of glucose, mannose, galactose, fructose, cellobiose, saccharose, glucosamine, and their stereoisomers, and their N-acetylamine derivatives, said process comprisingforming one new glycosidic bond for each substituent bound to the phosphane by reacting a hydrocarbon halide of the formulaZ'--X IIwherein Z' has the definition of Z with any --OH protected and X is chlorine, bromine or fluorine,with a phosphane of the formulaAr.sup.1.sub.3-x P[Ar.sup.2 (OH).sub.y ].sub.x IIIin a reaction medium, which contains at least two immiscible liquid phases, at 0.degree. to 80.degree. C. in the presence of a base and a phase transfer catalyst to form a phosphane of the formulaAr.sup.1.sub.3-x P[Ar.sup.2 (OZ.sup.1).sub.y ].sub.x IVand removing the protective groups to form the compound of Formula 1.