Patent ID: 6710184
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A process for preparing a crystalline solid of carvedilol Form II comprising the steps of:heating crystalline carvedilol or a solvate thereof characterized by data selected from the group consisting of a PXRD pattern with peaks at about 6.5, 7.3, 16.0, and 30.5Â±0.2 degrees two-theta; a DSC thermogram with endothermic peaks at about 74Â° C. and 112Â° C.; and a FTIR spectrum with peaks at about 613, 740, 994, 1125, 1228, 1257, 1441, 1508, 1737, 2840, 3281, 3389, and 3470 cmâˆ’1 until the crystalline carvedilol is dry, mixing carvedilol Form II with the dry crystalline carvedilol, and storing the mixture for a holding time sufficient to transform the dry crystalline carvedilol into Form II.