Patent ID: 8420348
Filing Date: 2013-04-16
Classification: C07K,G01N

Abstract:
1. A monoclonal rabbit antibody, or antigen-binding fragment thereof, against integrin with insect-derived glycosylation pattern and/or integrin with another eukaryotic glycosylation pattern, each comprising at least a light chain variable region (VL) and a heavy chain variable region (VH), wherein the antibody has antigen binding specificity for an exposed epitope of an extracellular integrin domain or extracellular integrin chain domain, and wherein the antibody is able to bind to intact heterodimers of integrin in formalin fixed paraffin embedded (FFPE) material and on viable cells with the substantially same specificity wherein said antibody is selected from the group consisting of: an antibody that binds to the extracellular domain of integrin αvβ3 and V an antibody that binds to the extracellular domain of integrin αvβ5 and V an antibody that binds to the extracellular domain of integrin αvβ6 and V an antibody that binds to the extracellular domain of integrin αvβ8 and V an antibody that binds to the extracellular domain of integrin chain αv and V