Patent ID: 6391902
Filing Date: 2002-05-21
Classification: C07D

Abstract:
A compound of the general Formula (II): wherein:R1, R2 and R3 are, independently, hydrogen, halogen, nitro, cyano, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, (optionally substituted with halogen), amino, alkylamino of 1 to 10 carbon atoms, â€”SO3H, â€”SO2NH2, â€”NHSO2R14, R15SO2â€”, carboxyl and aryl of 6 to 12 carbon atoms, or an acyl substituent selected from formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms; Y is â€”NR4 or â€”CR5R6; X is â€”NR4, when Y is â€”CR5R6; X is â€”CR5R6, when Y is â€”NR4; R4 is hydrogen, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl of 6 to 12 carbon atoms, or an acyl substituent selected from formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atolms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms and arylalkylsulfonyl of 7 to 12 carbon atoms; R5 and R6 are independently hydrogen, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl of 6 to 12 carbon atoms, or fluorine; Z substituted at position a is selected from group consiting of M is an alkali metal cation or an alkaline earth metal cation; R7 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aralkyl of 7 to 20 carbon atoms, or aryl of 6 to 12 carbon atoms; R8 and R9 are, independently, hydrogen, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aralkyl of 7 to 20 carbon atoms, or aryl of 6 to 12 carbon atoms; R10, R11, R12 and R13 are independently, alkyl of 1 to 10 carbon atoms; R14 is a straight chain alkyl of 1 to 10 carbon atoms; R15 is a straight chain alkyl of 1 to 10 carbon atoms (optionally substituted with halogen); aroyl is â€”C(O)aryl; aryl is a homocyclic aromatic radical, whether or not fused having 6 to 12 carbon atoms optionally substituted with one to three substituents each independently selected from the group halogen, carboxy, alkyl of 1 to 10 carbon atoms, nitro, amino, alkoxy of 1 to 10 carbon atoms, and alkylamino of 1 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof.