Patent ID: 6716586
Filing Date: 2004-04-06
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method for determining the dosing of a peptide that inhibits the interaction of an IGF with any one of its binding proteins comprising:(a) measuring the level of IGF bound to an IGFBP in a body fluid; (b) contacting said fluid with a peptide comprising an amino acid sequence that is SEQ ID NO:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 using single or multiple doses; (c) re-measuring the levels of IGF bound to an IGFBP after (b), wherein a decrease in the level of bound IGF is an indication of an increase in the level of unbound IGF; and (d) determining the dose of the peptide required to produce the desired level of unbound IGF.