Patent ID: 6469062
Filing Date: 2002-10-22
Classification: A61K,A61P

Abstract:
A method for promoting bile secretion comprising administering an effective amount of a 15-keto-prostaglandin compound represented by the general formula (I): wherein W1, W2 and W3 are carbon or oxygen atoms; L, M and N are hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, hydroxy(lower)alkyl or oxo, wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have one or more double bond(s); A is â€”CH2OH, â€”COCH2OH, â€”COOH or its functional derivative; B is â€”CH2â€”CH2â€”, â€”CH&boxH;CH&boxH; or â€”Câ‰¡Câ€”; R1 is a divalent saturated or unsaturated lower-medium aliphatic hydrocarbon residue, which is unsubstituted or substituted by halogen, alkyl, hydroxy, oxo, aryl or heterocyclic group; and Ra is a saturated or unsaturated lower-medium aliphatic hydrocarbon residue, which is unsubstituted or substituted by halogen, oxo, hydroxy, lower alkyl, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group; cyclo(lower)alkyl; cyclo(lower)alkyloxy; aryl; aryloxy; heterocyclic group; or heterocyclic-oxy group, to a subject having a condition or disease associated with bile secretion deficiency.