Patent ID: 6491950
Filing Date: 2002-12-10
Classification: A61K

Abstract:
A sustained/prolonged release pharmaceutical unit dosage form comprising a hard shell capsule containing a formulation comprising:(a) a water soluble medicament selected from the group consisting of a pharmaceutically acceptable addition salt of hydroxyzine, a pharmaceutically acceptable addition salt of metoprolol, niacin, caffeine, theophylline, a pharmaceutically acceptable acid addition salt of diltiazem, a pharmaceutically acceptable acid addition salt of albuterol, a pharmaceutically acceptable acid addition salt of metformin, a pharmaceutically acceptable acid addition salt of metronidazole, a pharmaceutically acceptable acid addition salt of metochlopramide, a pharmaceutically acceptable acid addition salt of ranitidine, and a pharmaceutically acceptable acid addition salt of captopril; (b) a high melting fatty acid ester selected from the group consisting of glyceryl behenate, glyceryl palmitostearate and glyceryl stearate; (c) an oil selected from the group consisting of corn oil, cottonseed oil, menhaden oil, safflower oil, sesame oil, shark-liver oil, soybean oil, olive oil and wheat germ oil; (d) a cellulosic polymer selected from the group consisting of a low-substituted hydroxypropyl ether cellulose polymer and a cellulosic polymer having methylether substitution; and (e) a polysorbate 80 surfactant.