Patent ID: 8084586
Filing Date: 2011-12-27
Classification: A61K,C07K,G01N,Y10S

Abstract:
1. A kit for determining the presence of doxorubicin in a patient sample comprising reagents in separate containers, one of the reagents being a conjugate of a carrier containing a functional amino or thiol group with a compound selected from the groups consisting of compounds of the formula: wherein A is Y is an organic spacing group; X is a functional group capable of binding to the amino or thiol group in said carrier; p is an integer from 0 to 1; a 14-substituted doxorubicin of the formula: wherein X, Y and p are as above and B is —CH and mixtures of a conjugate of a carrier with the compound of formula II-A and a conjugate of a carrier with the compound of formula II-B; and the other reagent being an antibody substantially selectively reactive with doxorubicin and not substantially cross-reactive to doxorubicin aglycone.