Patent ID: 7671206
Filing Date: 2010-03-02
Classification: A61K,A61P,C07D,C07K,Y02P

Abstract:
1. A process for the synthesis of a substantially pure stereoisomer of a compound of formula (I) wherein R R X is a pharmaceutically acceptable anion; and Y is an organic residue selected from the group consisting of or mixtures thereof; which comprises a) reacting an enantiomerically pure compound of formula (IV) b) transforming said substantially pure stereoisomer of a compound of formula (III), or mixtures thereof, into a substantially pure stereoisomer of a compound of formula (II) wherein or mixtures thereof; the transformation comprising the steps of (A) reacting a substantially pure stereoisomer of a compound of formula (III), or mixtures thereof wherein R wherein the dotted line together with the nitrogen atom form a substituted or unsubstituted heteroaryl, to prepare a substantially pure stereoisomer of a compound of formula (II), or mixtures thereof wherein R (B) reacting a substantially pure stereoisomer of a compound of formula (III), or mixtures thereof wherein R wherein Ra and Rb are those previously defined, and optionally, the resulting mixture is quenched with a compound of formula (X) wherein R (C) reacting a substantially pure stereoisomer of a compound of formula (III), or mixtures thereof wherein R c) contacting said substantially pure stereoisomer of a compound of formula (II), or mixtures thereof, with an acid media comprising an acid of formula HX, wherein X is defined as above, to render said substantially pure stereoisomer of a compound of formula (I), or mixtures thereof.