Patent ID: 6313113
Filing Date: 2001-11-06
Classification: C07D

Abstract:
A compound of formula (I) ##STR57##its derivatives, its analogues, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein X represents O or S; R.sup.1, R.sup.2, R.sup.3, R.sup.4 may be same or different and represent hydrogen, halogen, hydroxy, cyano, nitro; or unsubstituted or substituted groups selected from alkyl, (C.sub.3 -C.sub.6)cycloalkyl, alkoxy, (C.sub.3 -C.sub.6)cycloalkyloxy, aryl selected from phenyl or naphthyl; aralkyl, heteroaryl selected from pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl or benzofuranyl; heteroaralkyl, heterocyclyl selected from aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl or piperazinyl; aryloxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylamino, arylamino, amino, aminoalkyl, hydroxyalkyl, alkoxyalkyl, thioalkyl, alkylthio, acyl selected from acetyl, propionyl or benzoyl; acylamino, aryloxycarbonylamino, aralkoxycarbonylamino, alkoxycarbonylamino, carboxylic acid or its derivatives, acyloxy, sulfonic acid or its derivatives; W represents O or S; R.sup.6 represents hydrogen; or unsubstituted or substituted groups selected from alkyl, (C.sub.3 -C.sub.6)cycloalkyl, aryl selected from phenyl or naphthyl; aralkyl, heterocyclyl, selected from aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl, or piperazinyl; heteroaryl selected from pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl or benzofuranyl; heteroaralkyl, acyl selected from acetyl, propionyl or benzoyl; hydroxyalkyl, aminoalkyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, alkylthio, or thioalkyl groups; R.sup.5 represents hydrogen, hydroxy or halogen or unsubstituted or substituted groups selected from alkyl, aryl selected from phenyl or naphthyl; heteroaryl selected from pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl or benzofuranyl; acyl selected from acetyl, propionyl or benzoyl; alkoxy, aralkyl, or aralkoxy; n is an integer ranging from 1-4; Ar represents an unsubstituted or substituted divalent aromatic or heterocyclic group, R.sup.7 and R.sup.8 may be same or different and individually represent hydrogen, halogen, hydroxy, lower alkyl, unsubstituted or substituted aralkyl, or together form a bond; and B represents an oxygen atom or a sulfur atom.