Patent ID: 8921565
Filing Date: 2014-12-30
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer or tautomer thereof, wherein: X1 is halogen; X2 is halogen; Y is O, —NH; each R1 is individually and independently halogen or H; each R2 is individually and independently C1-C6 alkyl, deuteroC1-C6alkyl wherein the alkyl moiety can be partially or fully deuterated, C3-C8 branched alkyl, deuteroC3-C8 branched alkyl wherein the alkyl moiety can be partially or fully deuterated, or C3-C8 cycloalkyl; R3 is C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, —NR6(R7), or —R4, wherein each alkyl, branched or cycloalkyl may be optionally substituted with cyano, C1-C6alkoxy, or hydroxy; each R4 is independently and individually selected from the group consisting of and wherein the symbol (##) is the point of attachment of the R4 moiety; R5 is C1-C6 alkyl; each R6 and R7 is individually and independently H, C1-C6 alkyl, or branched C3-C8 alkyl; n is 0, 1, or 2.