Patent ID: 6528510
Filing Date: 2003-03-04
Classification: A61P,C07D

Abstract:
A compound of Formula I or a pharmaceutically acceptable salt thereof whereinR1 is H, a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R2 is H, a straight or branched alkyl of 1-5 carbons; R3 is H, (CRâ€²2)nOR, (CRâ€²2)nN(R)2, (CRâ€²2)nNRâ€²COR, (CRâ€²2)nCO2R, (CRâ€²2)nOCOR, (CRâ€²2)nCON(R)2, (CRâ€²2)nOCON(R)2, (CRâ€²2)nR, (CRâ€²2)nNRâ€²CON(R)2, (CRâ€²2)nNRâ€²CO2R, (CRâ€²2)nOSO2N(R)2, (CRâ€²2)nNRâ€²SO20R, (CRâ€²2)nNRâ€²SO2N(R)2, (CRâ€²2)nOSO2R, (CRâ€²2)nNRâ€²SO2R, (CRâ€²2)nSOpR, (CRâ€²2)nNRâ€²CSN(R)2, (CRâ€²2)nNRâ€²C(NRâ€²)N(R)2, (CRâ€²2)nSO2N(R)2, (CRâ€²2)nC(NRâ€²)N(R)2, (CRâ€²2)nCOR, O(CRâ€²2)mOR, NR(CRâ€²2)mOR, F, Cl, Br, CF3, CN, or &boxH;O; R4, R5, and R6 are independently H, a straight or branched alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons, (CRâ€²2)nOR, (CRâ€²2)nN(R)2, F, Cl, Br, CN, CF3, &boxH;O, (CRâ€²2)pNRâ€²COR, (CRâ€²2)pSOpR, (CRâ€²2)pR, (CRâ€²2)pOCOR, O(CRâ€²2)mOR, NR(CRâ€²2)mOR, (CRâ€²2)pNRâ€²CON(R)2, (CRâ€²2)pOCON(R)2, (CRâ€²2)pNRâ€²CO2R, (CRâ€²2)pCOR, (CRâ€²2)pCO2R, (CRâ€²2)pCON(R)2, (CRâ€²2)pNRâ€²SO2R, (CRâ€²2)pSO2N(R)2, (CRâ€²2)pNRâ€²SO2OR, (CRâ€²2)pOSO2N(R)2, (CRâ€²2)pNRâ€²SO2N(R)2, (CRâ€²2)pC(NRâ€²)N(R)2, (CRâ€²2)pNRâ€²C(NRâ€²)N(R)2, (CRâ€²2)pHet; any two of R1-R3 or R4-R6 may together form a ring of 5-6 total atoms which may contain 0-3 heteroatoms; n is an integer of from 0 to 3; m is an integer of from 2 to 4; p is an integer from 0 to 2; R7 is a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R is independently H, a straight or branched alkyl of 1-4 carbons, (CH2)nPh, or a (CH2)nheterocycle of 5-6 atoms containing 1-2 heteroatoms and wherein the (R)2 in N(R)2 may form a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, ORâ€², CN, CO2Râ€², N(Râ€²)2, NRâ€²CORâ€², CF3, or &boxH;O; Râ€² is independently H, a straight or branched alkyl of 1-4 carbons, or phenyl; Râ€³ is independently H, a straight or branched alkyl of 1-4 carbons, F, Cl, Br, ORâ€², or N(Râ€²)2; Ar1 is phenyl and Ar2 is Het; wherein Het is a heterocycle of from 5-6 atoms having from 1-4 heteroatoms or a fused heterocycle of from 9-10 atoms having 1-3 heteroatoms Ar2 is Het wherein Het is a heterocycle of from 5-6 atoms having 1-4 heteroatoms selected from furan, pyrrole, thiophene, oxazole, isoxazole, thiazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, tetrazole, pyridine, pyridazine, pyrimidine, or pyrazine, or a fused heterocycle of from 9-10 atoms having from 1-3 heteroatoms selected from: benzofuran, indole, indoline, benzothiophene, benzimidazole, benzthiazole, benzoxazole, quinoline, isoquinoline, cinnoline, quinazoline and quinoxaline.