Patent ID: 9066933
Filing Date: 2015-06-30
Classification: A61K,A61P,B82Y

Abstract:
1. An oral hemoglobin based oxygen carrier delivery system configured to release a hemoglobin based oxygen carrier in the intestinal tract of a patient such that the hemoglobin is delivered to the patient's bloodstream in a substantially undegraded form, the system including an enteric-coated capsule or tablet surrounding a pharmaceutical composition comprising a nanoparticle solution including hemoglobin-loaded nanoparticles, the hemoglobin-based oxygen carrier comprising one or more of purified hemoglobin, cross-linked hemoglobin, non-polymeric tetrameric hemoglobin, polymeric hemoglobin, or conjugated hemoglobin, and the hemoglobin-loaded nanoparticles being embedded into a polyelectrolyte complex under an aqueous-based condition at room temperature via polyelectrolyte complexation to result in a plurality of positively charged hemoglobin-loaded nanoparticles having an average particle size equal to or more than 150 nm, a zeta potential of 41±10 mV, and an encapsulation efficiency of about 28.7% or more.