Patent ID: 7431925
Filing Date: 2008-10-07
Classification: A61K,A61P,C07K

Abstract:
1. A method of diagnosing a patient, the method comprising: (a) selecting a ligand that binds to a heat stable toxin biological receptor; (b) preparing a first generation of monoclonal antibodies against the receptor binding ligand; (c) isolating the first generation of monoclonal antibodies; (d) preparing monoclonal anti-idiotypic antibodies against the first generation of monoclonal antibodies to result in internal image anti-receptor antibodies; (e) isolating the internal image anti-receptor antibodies; (f) conjugating the internal image anti-receptor antibodies to a photoactive dye; (g) administering a concentration of the conjugate of step f to a patient effective to diagnose the patient; (h) allowing the conjugate to accumulate at a target site within the patient; and (j) exposing the target site to light sufficient to activate the photoactive dye to image the target site.