Patent ID: 6228870
Filing Date: 2001-05-08
Classification: C07D

Abstract:
A compound of formula: ##STR30##wherein A is CX or N;X is hydrogen, halo, nitro, cyano, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluorinated C.sub.1 -C.sub.4 alkyl, fluorinated C.sub.1 -C.sub.4 alkoxy, (CH.sub.2).sub.1-4 OR.sup.a, C.sub.3 -C.sub.8 cycloalkyl, fluorinated C.sub.3 -C.sub.8 cycloalkyl, N(R.sup.a).sub.2, N(R.sup.a)COR.sup.a, N(R.sup.a)CON(R.sup.a).sub.2, N(R.sup.a)SO.sub.2 R.sup.a, N(R.sup.a)SO.sub.2 N(R.sup.a).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.a, (CH.sub.2).sub.0-4 CON(R.sup.a).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.a).sub.2, or (CH.sub.2).sub.0-4 SO.sub.2 R.sup.a ;Y is hydrogen, halo, nitro, cyano, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluorinated C.sub.1 -C.sub.4 alkyl, fluorinated C.sub.1 -C.sub.4 alkoxy, (CH.sub.2).sub.1-4 OR.sup.a, C.sub.3 -C.sub.8 cycloalkyl, fluorinated C.sub.3 -C.sub.8 cycloalkyl, N(R.sup.a).sub.2, N(R.sup.a)COR.sup.a, N(R.sup.a)CON(R.sup.a).sub.2, N(R.sup.a)SO.sub.2 R.sup.a, N(R.sup.a)SO.sub.2 N(R.sup.a).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.a, (CH.sub.2).sub.0-4 CON(R.sup.a).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.a).sub.2, or (CH.sub.2).sub.0-4 SO.sub.2 R.sup.a ;R.sup.1 is hydrogen, cyano, CO.sub.2 R.sup.a, C(.dbd.O)N(R.sup.a).sub.2, C.sub.1 -C.sub.6 alkoxy, tetrazole, phenyl, or mono- or poly-substituted phenyl; wherein each of the substituents on the substituted phenyl is independently selected from halo, nitro, cyano, hydroxy, N(R.sup.a).sub.2, N(R.sup.a)C(.dbd.O)R.sup.a, N(R.sup.a)C(.dbd.O)N(R.sup.a).sub.2, NR.sup.a SO.sub.2 R.sup.a, NR.sup.a SO.sub.2 N(R.sup.a).sub.2, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, fluorinated C.sub.1 -C.sub.6 alkyl, fluorinated C.sub.3 -C.sub.8 cycloalkyl, fluorinated C.sub.1 -C.sub.6 alkoxy, (CH.sub.2).sub.1-4 OR.sup.a, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.a, (CH.sub.2).sub.0-4 C(.dbd.O)N(R.sup.a).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.a).sub.2, and (CH.sub.2).sub.0-4 SO.sub.2 R.sup.a ;R.sup.2 is CH.sub.2 OR.sup.b ;R.sup.a is hydrogen, C.sub.1 -C.sub.6 alkyl, or fluorinated C.sub.1 -C.sub.6 alkyl;R.sup.b is hydrogen, or C.sub.1 -C.sub.6 alkyl;n is an integer of from 1 to 3; andq and r are each independently integers of from 0 to 3;or a pharmaceutically acceptable salt thereof.