Patent ID: 6784161
Filing Date: 2004-08-31
Classification: A61K,A61P

Abstract:
A method for the treatment of an hepatitis C infection in a host comprising administering to said host a therapeutically effective amount of a compound having the formula Ib or a pharmaceutically acceptable salt thereof: whereinB is a nucleotide purine radical, a nucleotide pyrimidine radical or an analogue of a nucleotide purine radical or a nucleotide pyrimidine radical, wherein said analogue is derived by replacement of a CH moiety by a nitrogen atom in a nucleotide purine or pyrimidine radical, replacement of a nitrogen atom by a CH moiety in a nucleotide purine or pyrimidine radical, or both; or derived by removal of ring substituents of said nucleotide purine radical or pyrimidine radical; or combinations thereof; and said analogue is optionally substituted by halogen, hydroxyl, amino, or C1-6 alkyl; Ra is H, monophosphate, diphosphate, triphosphate, carbonyl which is substituted by a straight, branched or cyclic alkyl having up to 6 C atoms wherein the alkyl is unsubstituted or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkenyl which is unsubstituted or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkynyl which is unsubstituted or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6, alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C6-10 aryl which is unsubstituted or mono- or di-substituted with OH, SH, amino, halogen or C1-6 alkyl, or Rc is, in each case independently, H, straight chain, branched chain or cyclic C1-6 alkyl which is unsubstituted or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkenyl which is unsubstituted or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkynyl which is unsubstituted or substituted by or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C6-10 aryl which is unsubstituted or mono- or di-substituted with OH, SH, amino, halogen or C1-6 alkyl, or a hydroxy protecting group; Q is C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl; Z is ORb; Rb is H, straight chain, branched chain or cyclic C1-6 alkyl which is unsubstituted or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkenyl which is unsubstituted or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C2-6 alkynyl which is unsubstituted or substituted by or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ, C1-6 acyl, or a hydroxy protecting group; D1 and D2 are each independently N3, F, or H, wherein D1 and D2 are not both H; or D1 and D2 together form &boxH;CH2, &boxH;CF2, or C3-cycloalkyl which is unsubstituted or substituted by halogen, nitro, CONH2, COOH, Oâ€”C1-6 alkyl, Oâ€”C2-6 alkenyl, Oâ€”C2-6 alkynyl, hydroxyl, amino, or COOQ.