Patent ID: 9084829
Filing Date: 2015-07-21
Classification: A61K,A61P,C07K

Abstract:
1. An immunoconjugate comprising a cytotoxic agent and a human or humanized antibody or functional fragment thereof, wherein the cytotoxic agent is a maytansinoid or a derivative thereof, wherein the human or humanized antibody or functional fragment thereof comprises an antigen-binding site that is specific for Mesothelin (SEQ ID NO:36), the antigen-binding site comprising a variable heavy chain comprising complementarity determining regions (CDRs) corresponding to SEQ ID NOS 3, 6, and 9 and a variable light chain comprising CDRs corresponding to SEQ ID NOS 12, 15, and 19, wherein the human or humanized antibody or functional fragment thereof exhibits invariant binding of Mesothelin, and wherein the cytotoxic agent and the human or humanized antibody or functional fragment thereof are linked by SPDB.