Patent ID: 8136675
Filing Date: 2012-03-20
Classification: A61M,B01D,D01D

Abstract:
1. A permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer, wherein said hydrophobic polymer is selected from the group consisting of polyarylethersulfone (PAES), polypropylene (PP), polysulfone (PSU), polymethylmethacrylate (PMMA), polycarbonate (PC), polyacrylonitrile (PAN), polyamide (PA), and polytetrafluoroethylene (PTFE), and wherein said membrane comprises a separation layer and the separation layer is the inner most layer of the hollow fibre membrane, and wherein said membrane allows passage of molecules having a molecular weight of 50,000 Daltons, with a sieving coefficient of about 0.7 in the presence of whole blood, has a sieving coefficient for IL-6 in the presence of whole blood of 0.9-1.0, and has a molecular weight exclusion limit of about 200,000 Daltons in water; wherein the membrane allows the retention of a portion of albumin in the presence of whole blood.