Patent ID: 6027748
Filing Date: 2000-02-22
Classification: A61K

Abstract:
A pharmaceutical tablet designed for the controlled release of active principles which exhibits a different biological absorption rate in the presence and in the absence of food, which comprises: a core having one or more layers, at least one of which serves as a vehicle for the active principle, while the other layer or layers, selected from the group consisting of erodible, gellable, and erodible and gellable hydrophilic polymers, function as a barrier, being initially impermeable to the passage of the active principle and said tablet being completely coated with one or more films of a biocompatible and biodegradable polymeric material, at least one of said films being of a gastro-resistant and entero-soluble material selected from the group consisting of: cellulose acetophthalate, cellulose acetopropionate, cellulose trimellitate, copolymers of methacrylic and acrylic acids, copolymers of methacrylic acid and methylmethacrylate and methylvinylether-maleic anhydride copolymers.