Patent ID: 8415295
Filing Date: 2013-04-09
Classification: A61P,C07F

Abstract:
1. A method for inhibiting dipeptidyl peptidase-IV comprising contacting dipeptidyl peptidase-IV with an effective amount of a compound of formula (I): including all cyclic isomers thereof, stereoisomers thereof, solvates thereof, hydrates thereof and pharmaceutically acceptable salts thereof, wherein: n is 1; X is CH Z is H, halogen, hydroxyl, (C optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; optionally, one of the bonds in the ring containing X is a double bond; R R R Set I: R Set II: R wherein R R R R s is 1 to 6; t is 0 to 6; and u is 0 to 3; and wherein a bond bisected by a wavy line signifies a point of attachment.