Patent ID: 8450528
Filing Date: 2013-05-28
Classification: C07C

Abstract:
1. A process for the preparation of 2,2-difluoroethylamine of formula (I) and/or a salt thereof, comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of formula (II) with a benzylamine compound of the formula (III) to give an N-benzyl-2,2-difluoroethanamine compound of formula (IV) in the presence of an acid scavenger, which comprises a compound which is able to inactivate and/or neutralize an acid; in which, in formula (II), Hal is chlorine, bromine or iodine, and, in the formulae (III) and (IV), R R and stage (ii): catalytic hydrogenation of the N-benzyl-2,2-difluoroethanamine compound of the formula (IV) obtained in the stage (i), by which 2,2-difluoroethylamine of the formula (I) and/or a salt thereof is obtained.