Patent ID: 7994299
Filing Date: 2011-08-09
Classification: A01K,A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
1. An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of: (a) polynucleotide sequences that hybridize to the full complement of SEQ ID NO: 1, under conditions of high stringency comprising hybridization in 5×SSPE, 5×Denhardt's solution and 0.5% SDS overnight at 55 to 60° C.; followed by a post hybridization wash at 0.5×SSC at 55-60° C.; (b) polynucleotide sequences having at least 85% sequence identity to SEQ ID NO: 1; (c) polynucleotide sequences that encode a polypeptide having at least 85% sequence identity to SEQ ID NO: 2; (d) nucleotides 119-686 of SEQ ID NO: 1; (e) polynucleotide sequences having at least 85% sequence identity to nucleotides 119-686 of SEQ ID NO: 1; (f) polynucleotide sequences that encode amino acids 25-213 of SEQ ID NO: 2; and (g) polynucleotide sequences that encode a polypeptide having at least 85% sequence identity to amino acids 25-213 of SEQ ID NO: 2, wherein the isolated nucleic acid molecule encodes a polypeptide that retains the biological activity of SEQ ID NO: 2 in regulating bone mineral content.