Patent ID: 9090694
Filing Date: 2015-07-28
Classification: A61K,A61P,C07K

Abstract:
1. An isolated human or human-adapted antibody antagonist or fragment thereof that specifically binds Domain I (SEQ ID NO: 9) of human interleukin-1 receptor like 1 (ST2L) and blocks interleukin-33 (IL-33)/ST2L interaction, comprising a heavy chain variable region (VH), a light chain variable region (VL), a heavy chain complementarity region (HCDR) 1 (HCDR1), 2 (HCDR2), 3 (HCDR3), a light chain complementarity region (LCDR) 1 (LCDR1), 2 (LCDR2) and 3 (LCDR3), wherein a. the HCDR1 comprises the amino acid sequence of SEQ ID NO: 97; b. the HCDR2 comprises the amino acid sequence of SEQ ID NO: 114; c. the HCDR3 comprises the amino acid sequence of SEQ ID NO: 84; d. the LCDR1 comprises the amino acid sequence of SEQ ID NO: 130; e. the LCDR2 comprises the amino acid sequence of SEQ ID NO: 90; and f. the LCDR3 comprises the amino acid sequence of SEQ ID NO: 134.