Patent ID: 6248764
Filing Date: 2001-06-19
Classification: C07D

Abstract:
A compound of formula I having the structure ##STR14##whereinR.sup.1 and R.sup.2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, phenyl or phenyl substituted with trifluoromethyl, chloro, methoxy, or trifluoromethoxy;R.sup.3 and R.sup.4 are each, independently, hydrogen, carboxyl, hydroxyl, hydoxyalkyl of 1-6 carbon atoms, aryloxycarbonyl of 7-13 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, mercapto, nitrile, nitro, amino, --NHSO.sub.2 CF.sub.3, carbamoyl, carboxyaldehyde, halogen, acylamino, or 3-hydroxy-cyclobut-3-ene-4-yl-1,2-dione,R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, or aralkyl of 7-13 carbon atoms;R.sup.6 and R.sup.7 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, or hydroxyalkyl of 1-6 carbon atoms; or R.sup.6 and R.sup.7 may be taken together as a diene unit having the structure --CH.dbd.CH--CH.dbd.CH--;W is S or O,X is --NR.sup.8 CH.sub.2 --, --NR.sup.8 --, or O;R.sup.8 is hydrogen or alkyl;Y is carbonyl, methylene, ethyl, or --NHCH.sub.2 --;Z is pyrazolyl, isoxazolyl, or isothiazolyl;or a pharmaceutically acceptable salt thereof.