Patent ID: 7824910
Filing Date: 2010-11-02
Classification: A61K

Abstract:
1. A method for transducing a protein or peptide pharmaceutical agent into a cell, comprising forming a conjugate by binding the pharmaceutical agent with a polymer which is chosen from polyalkylenepolyamines, polyallylamines, polyvinylamines, poly(dialkylaminoalkyl (meth)acrylate)s, poly(meth) acrylic dialkylaminoalkylamides, polyamidines, polyvinylpyridines, polyvinylimidazoles and co-polymers and salts thereof, and having a cation value of more than 2 and no more than 250 and then transducing the conjugate into the cell, wherein the pharmaceutical agent and polymer are either directly covalently bound without any intermediate therebetween, or are covalently bound by a bifunctional crosslinking reagent, and wherein the pharmaceutical agent is a fluorescently labeled protein or peptide.