Patent ID: 6288103
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR18##whereinR.sup.1 is independently selected from trifluoromethyl, C.sub.1-4 alkyl, halo, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, C.sub.1-4 alkanoyloxy, amino, cyano, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, C.sub.1-4 alkanoylamino, nitro, carbamoyl, C.sub.1-4 alkoxycarbonyl, thiol, C.sub.1-4 alkylsulphanyl, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, sulphonamido, carbamoylC.sub.1-4 alkyl, N--(C.sub.1-4 alkyl)carbamoylC.sub.1-4 alkyl, N--(C.sub.1-4 alkyl).sub.2 carbarnoyl-C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl, C.sub.1-4 alkoxyC.sub.1-4 alkyl, morpholino, pyrrolidinyl, carboxyC.sub.1-4 alkylamino, R.sup.3 and --OR.sup.3 (where R.sup.3 is optionally substituted aryl or an optionally substituted 5- or 6-membered heteroaryl ring);p is 1-4 and R.sup.1 may have the same or different values when p is 2-4;T is of the formula(CHR.sup.4).sub.m --(SO.sub.2)--(CHR.sup.4).sub.s --(where R.sup.4 is independently selected from hydrogen or C.sub.1-4 alkyl, m=0-2, s=0-2, m+s=0-2, and R.sup.4 may take different values when m+s=2;X is carboxyl, tetrazol-5-yl, cyano, SO.sub.3 H, --SO.sub.2 NHR.sup.4 (where R.sup.4 is as defined above), --SO.sub.2 NHAr (where Ar is an optionally substituted phenyl or optionally substituted 5 or 6 membered heteroaryl ring), --CONHR.sup.5 (where R.sup.5 is H, cyano, OH, --SO.sub.2 --C.sub.1-4 alkyl, --SO.sub.2 CF.sub.3, --SO.sub.2 -phenyl, --(CHR.sup.4).sub.r --COOH, (where r is 1-3 and R.sup.4 (as defined above) may take different values when r is 2-3)), or X is a group of formula (II) ##STR19##or X represents a group of formula (III) ##STR20##where the groups defined as R.sup.4 may have different values within the definition of R.sup.4 above;A is selected from phenyl, naphthyl, furyl, pyridyl and thienyl;R.sup.2 is independently selected from trifluoromethyl, propyl, isopropyl, t-butyl, cyclopropyl, halo, hydroxy, trifluoromethoxy, cyano, C.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, C.sub.1-4 alkanoyloxy, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, C.sub.1-4 alkanoylamino, nitro, carboxy, carbamoyl, C.sub.1-4 alkoxycarbonyl, thiol, C.sub.1-4 alkylsulphanyl, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, sulphonamido, carbamoylC.sub.1-4 alkyl, N--(C.sub.1-4 alkyl)carbamoylC.sub.1-4 alkyl, N--(C.sub.1-4 alkyl).sub.2 carbamoyl-C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl, C.sub.1-4 alkoxyC.sub.1-4 alkyl or two R.sup.2 values together may form a divalent radical of the formula --O(CH.sub.2).sub.1-4 O-- attached to adjacent carbon atoms on ring A;q is 1-4 and R.sup.2 may have the same or different values when q is 2-4;Z is hydrogen, fluoro, chloro, bromo, iodo, methyl, trifluoromethyl, hydroxymethyl, methoxy, methylsulphanyl, methylsulphinyl, methylsulphonyl or carboxyC.sub.3-6 cycloalkyl, --(CHR.sup.4)r-NR.sup.6 R.sup.7 (where r is 0-2, R.sup.6 and R.sup.7 are independently selected from H and C.sub.1-4 alkyl or R.sup.6 and R.sup.7 together with the nitrogen to which they are attached form a 5 or 6 membered non-aromatic ring optionally containing one further heteroatom selected from O, N or S);or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof.