Patent ID: 6525026
Filing Date: 2003-02-25
Classification: A61K,C07K

Abstract:
A compound of formula I: whereinR1 and R2 together with the nitrogen atom bonded to R2 and the SO2 group bonded to R1 are joined to form a heterocyclic group or substituted heterocyclic group; R3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; R5 is â€”(CH2)xâ€”Arâ€”R5â€² where R5â€² is selected from the group consisting of â€”Oâ€”Zâ€”NR8R8â€² and â€”Oâ€”Zâ€”R12 wherein R8 and R8â€² are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, and where R8 and R8â€² are joined to form a heterocycle or a substituted heterocycle, R12 is selected from the group consisting of heterocycle and substituted heterocycle, and Z is selected from the group consisting of â€”C(O)â€” and â€”SO2â€”, Ar is aryl, heteroaryl, substituted aryl or substituted heteroaryl, x is an integer of from 1 to 4; Q is â€”C(X)NR7â€” wherein R7 is selected from the group consisting of hydrogen and alkyl; and X is selected from the group consisting of oxygen and sulfur; and pharmaceutically acceptable salts thereof.