Patent ID: 8222291
Filing Date: 2012-07-17
Classification: A61P,C07D

Abstract:
1. A compound having the formula (1): or a pharmaceutically acceptable salt or hydrate form thereof; and including any stereoisomeric forms thereof; wherein each J and J′ is independently H, CN, C1-C4 alkyl or C1-C4 alkyloxycarbonyl; each Y and Y′ independently represents optionally substituted C1-C8 alkyl, C5-C12 aryl, C5-C20 arylalkyl, or a heteroform of one of these; or is ═O, OR, SR, S(O)R, SO and wherein two Y or Y′ groups on the same ring can cyclize to form a 3-6 membered ring that can be saturated, unsaturated or aromatic, and which ring may include a heteroatom selected from O, S and N as a ring member and may be substituted; each W and W′ independently represents C═O, C═S, or an optionally substituted C each X and X′ independently represents an optionally substituted C5-C20 ring system comprising at least one aromatic ring and up to four heteroatoms selected from N, O and S, as a ring member, and can represent either a single 5-15 membered cyclic group or two 5-10 membered cyclic groups that are both attached to the same atom of W or W′, provided that each X and X′ comprises at least one aryl or heteroaryl ring; each Q and Q′ independently represents —CH each n and n′ is independently 0-3; each m and m′ is independently 0-4; each R each Z and Z′ is independently an optionally substituted C1-C6 aminoalkyl; and L represents a linker that is a C2-C20 hydrocarbyl group, optionally containing from 1-6 heteroatoms selected from N, O and S, which linker is 2 to 10 atoms in length when counted along the shortest path between Q and Q′, and which may be optionally substituted; with the proviso that L does not comprise a disulfide bond.