Patent ID: 6271224
Filing Date: 2001-08-07
Classification: A61K,A61P,Y10S

Abstract:
A method of treating glaucoma, ocular hypertension, ocular ischemia and related disorders in a patient with one or more of such conditions, comprising administering to said patient a composition comprising an ophthalmically effective amount of a compound of formula: ##STR8##wherein R.sup.1 represents a hydrogen atom, a chlorine atom or a hydroxyl group; andwhenR.sup.1 represents a hydrogen atom,A represents an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, R.sup.2 and R.sup.3 are directly bonded with each other, thereby forming a trimethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, andR.sup.4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; with the proviso that the following compound be excluded: ##STR9##whenR.sup.1 represents a chlorine atom or a hydroxyl group,A represents an alkylene group having 2 to 6 carbon atoms, said group being unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms,R.sup.2 and R.sup.3 are not bonded with each other and each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R.sup.2 and R.sup.3 are directly bonded with each other, thereby forming an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms or a trimethylene group unsubstituted or substituted with alkyl group having 1 to 6 carbon atoms, andR.sup.4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an amidino group;and pharmaceutically acceptable salts thereof; and an ophthalmically acceptable carrier therefore.