Patent ID: 8740872
Filing Date: 2014-06-03
Classification: A61K,B82Y

Abstract:
1. A method of treating a cardiac disorder in a subject in need of such treatment, comprising: administering a nanoparticle composition to a vascular component of the subject, the nanoparticle composition comprising a plurality of nanoparticles, each nanoparticle comprising a magnetically-susceptible core, a biocompatible polymer shell which surrounds the magnetically-susceptible core, and an active agent which is embedded, loaded, and/or absorbed on or within, or otherwise linked, attached, and/or bound to the biocompatible polymer shell; establishing a magnetic gradient about a targeted portion of the intrinsic cardiac autonomic nervous system (intrinsic CANS) of the subject, the targeted portion comprising at least one ganglionated plexi, the magnetic gradient causing the nanoparticles to be retained in the targeted portion of the intrinsic CANS, and wherein the active agent is released from the biocompatible polymer shell of the nanoparticles causing reduction or suppression of the at least one ganglionated plexi, thereby treating the cardiac disorder.