Patent ID: 6376524
Filing Date: 2002-04-23
Classification: A61P,C07C

Abstract:
A compound of formula I or formula II: where:Aâ€”B is selected from the group consisting of â€”CHRXâ€”CHRXâ€”, â€”CRY&boxH;CRYâ€”, â€”CHRYâ€”Oâ€”, â€”Oâ€”CHRYâ€”, NR1â€”C(&boxH;O)â€”, â€”C(&boxH;O)â€”NR1, â€”S(O)0-2â€”CHRXâ€”, â€”CHRXâ€”S(O)0-2â€”, â€”SO2â€”NR1â€”, â€”NR1â€”SO2â€”, â€”C(&boxH;O)â€”CHRXâ€”, â€”CHRXâ€”C(&boxH;O)â€”, and cycloalkylene; each RX is independently selected from the group consisting of hydrogen, hydroxy, alkyl, haloalkyl, aminoalkyl, guanidinoalkyl, alkoxy, amino, alkylamino, dialkylamino, cycloamino, alkylcarbonylamino, guanidino, carboxy, alkoxycarbonyl, and tetrazole; each RY is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, carboxy, and alkoxycarbonyl; each R1 is independently selected from the group consisting of hydrogen and lower alkyl; R2 is selected from the group consisting of hydrogen, halo and hydroxy; R3 is selected from the group consisting of optionally fluorinated methoxy and optionally fluorinated ethoxy; R4 is selected from the group consisting of hydrogen, hydroxy, amino, alkylamino, dialkylamino, and cycloamino; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, alkoxy, amino, alkylcarbonylamino, alkylsulfonylamino, benzenesulfonylamino, toluenesulfonylamino, carboxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cycloaminocarbonyl, and alkoxycarbonyl; R6 is selected from the group consisting of hydrogen, halo and hydroxy; R8, R9, R11, R12, R14, R15, R17 and R18 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, methoxy, and ethoxy; R16 is selected from the group consisting of hydrogen, hydroxy, halo, haloalkyl, alkoxy, aminocarbonyl, alkylaminocarbonyl, carboxy, alkoxycarbonyl, â€”SO2NR12, and â€”NR1SO2R1; R19 is selected from the group consisting of hydrogen, hydroxy, halo, haloalkyl, alkoxy, aminocarbonyl, alkylaminocarbonyl, carboxy, alkoxycarbonyl, â€”SO2NR12, and â€”NR1SO2R1; in which: (1) at least one of R2, R4, and R6 is not hydrogen; and (2) at least one of R14, R15, R16, R17, and R18 in formulae I, III, IV, and VI, or at least one of R14, R15, R17, R18, and R19 in formula II, is not hydrogen; or a pharmaceutically acceptable salt thereof.