Patent ID: 6197785
Filing Date: 2001-03-06
Classification: A61P,C07D,C07F

Abstract:
A method of treating a cardiovascular disorder in an animal comprising administering to said animal an effective amount of a compound of formula I: ##STR316##or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein:R.sup.1, when present, is hydrogen or lower alkyl;R.sup.2 is lower alkyl, aryl, aralkyl, lower alkanoyl, or --(CH.sub.2).sub.n --(CHOH).sub.y (CH.sub.2).sub.m A, wherein n is 1-4, y is 0 or 1, m is 0-5, and A is cycloalkyl, cycloalkenyl, lower alkanoyl, aryl, aralkyl, --NH.sub.2, --NH--(lower alkyl), ##STR317##Y represents the atoms necessary to form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic, which may be substituted or unsubstituted;Z is (i) --CHR.sup.2 CHR.sup.3 -- where R.sup.2 and R.sup.3 are independently hydrogen, alkyl, aryl or aralkyl; or(ii) --R.sup.6 C.dbd.CR.sup.3 -- where R.sup.6 and R.sup.3 are independently hydrogen, lower alkyl, aryl, aralkyl, chlorine, bromine or --NR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are independently hydrogen or lower alkyl, or, R.sup.6 and R.sup.3, taken together, form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic.