Patent ID: 8545880
Filing Date: 2013-10-01
Classification: A61K,A61P

Abstract:
1. A once-a-day composition comprising: (a) an immediate release component comprising bupropion or a pharmaceutically acceptable salt thereof wherein the immediate release component is a powder, a granule or an uncoated active pellet; (b) a first pellet comprising a first core containing a pharmaceutically acceptable salt of bupropion and an enteric coating applied to the first core wherein the enteric coating consists of: (c) a second pellet comprising a second core containing a pharmaceutically acceptable salt of bupropion and a sustained release coating applied to the second core wherein the sustained release coating comprises a mixture of: wherein said composition is a tablet or capsule that contains 75 to 450 mg of bupropion or a pharmaceutically acceptable salt thereof, and the ratio of first pellet to second pellet is about 30:70 to about70:30 and provides an in vivo plasma profile selected from: (a) a mean C (b) a mean AUC (c) a mean T