Patent ID: 9050304
Filing Date: 2015-06-09
Classification: A61K,A61P,Y02A

Abstract:
1. A method for increasing stem cell production in a donor, said method comprising administering to said donor an amount of a covalent conjugate between a G-CSF peptide having the amino acid sequence according to SEQ ID NO: 1 and a poly(ethylene glycol) (PEG) group, wherein said covalent conjugate comprises a structure according to the formula wherein q is 0 or 1; and Sia-PEG has a structure according to the formula: in which n is an integer from 400 to 500, and wherein said amount is in a range from about 1 mg to about 20 mg or is a unit dosage form selected from 50 μg/kg, 100 μg/kg, and 200 μg/kg.