Patent ID: 7235537
Filing Date: 2007-06-26
Classification: A61P,C04B,C07D,C07F

Abstract:
1. A phosphate prodrug of a compound having the formula and pharmaceutically accepted salts and solvates thereof, wherein: R R or R R′, R″ and R″ independently are selected from hydrogen, lower alkyl, lower alkenyl, aryl and arylalkyl; R″″is selected from lower alkyl, lower alkenyl, aryl and arylalkyl; or any two of R′, R″, R″′ or R″″ together with the atom to which they are attached form a 4 to 10 membered carbocyclic, heteroaryl or heterocyclic ring, each of which is optionally substituted with one to three groups independently selected from halogen, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl; R R R R W is selected from heteroaryl, heterocyclyl, -C(O)OR R R m is 0, 1, 2, 3, 4 or 5; and j is 1 or 2.