Patent ID: 7393652
Filing Date: 2008-07-01
Classification: G01N

Abstract:
1. An in vitro method for identifying a chemical compound that directly enhances binding of an FKBP12.6 binding protein (FKBP12.6) to a PKA-phosphorylated type 2 ryanodine receptor (RyR2), the method comprising: (a) exposing PKA-phosphorylated RyR2 to FKBP12.6, in the presence or absence of a candidate chemical compound in vitro; (b) determining the amount of FKBP12.6 bound to PKA-phosphorylated RyR2 in the presence and absence of the compound, wherein an increased amount of FKBP12.6 bound to PKA-phosphorylated RyR2 in the presence of the compound indicates that the compound directly enhances binding of FKBP12.6 to PKA-phosphorylated RyR2; thereby (c) identifying the compound as a compound that directly enhances binding of FKBP12.6 bound to PKA-phosphorylated RyR2.