Patent ID: 9021864
Filing Date: 2015-05-05
Classification: B01L,C12Q,G01N

Abstract:
1. A method for sensing molecules, the method comprising: providing a twin-nanopore probe comprising a first channel and a second channel; generating a positive pressure by a first pressure-controlled reservoir connected to the first channel; generating a negative pressure by a second pressure-controlled reservoir connected to the second channel; wherein a container comprises solvent with the molecules, a tip of the twin-nanopore probe being submerged in the container of the solvent with the molecules; and wherein the first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with an ionic fluid; driving the ionic fluid out of the first channel by the first pressure-controlled reservoir; drawing in the ionic fluid, mixed with the molecules and the solvent, through the second channel by the second pressure-controlled reservoir; and detecting a change in a magnitude of ionic current through the second nanopore of the twin-nanopore probe in response to at least one of the molecules passing through the second nanopore via the positive and negative pressures.