Patent ID: 8722875
Filing Date: 2014-05-13
Classification: A61P,C12N

Abstract:
1. A nucleic acid molecule comprising a double-stranded structure that is optionally covalently linked and each strand of the doubled-stranded structure has a length of 18-29 nucleotides, wherein the first stretch and/or the second stretch have a plurality of modified nucleotides having a modification at the 2′ position wherein the first strand comprises a first stretch of contiguous nucleotides and said first stretch is at least partially complementary to a target nucleic acid, and wherein the second strand comprises a second stretch of contiguous nucleotides and said second stretch is at least partially complementary to the first stretch, wherein the first stretch consists of a nucleotide sequence according to SEQ ID NOS: 6, 34, 20 or 36 and the second stretch consists of a nucleotide sequence according to SEQ ID NOS: 7, 35, 21 or 37.