Patent ID: 8088760
Filing Date: 2012-01-03
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) or Formula (II): wherein: Y is selected from the group consisting of a) an aryl group optionally substituted with 1, 2, or 3 R b) a heteroaryl group optionally substituted with 1, 2, or 3 R c) a L-T group where L is selected from the group consisting of alkenylene, alkylene, alkynylene, cycloalkylene and spiroheterocycle and T is selected from the group consisting of heteroaryl, heteroarylalkoxy, heteroaryloxy, heteroarylthio, heteroarylalkylthio, heterocycle, heterocycloalkoxy, heterocycloalkylthio, heterocyclooxy, heterocyclothio, and NR d) a non-aromatic 4, 5, 6, 7, 8, 9, 10, 11, or 12-membered monocyclic or bicyclic heterocycle ring having 1 or 2 nitrogen atoms and, optionally, one sulfur or oxygen atom, wherein the heterocycle is optionally substituted with 1, 2, or 3 R R 1 , R 2 , and R 3 , are each independently selected from the group consisting of hydrogen, halogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, cycloalkyl, alkynyl, cyano, haloalkoxy, haloalkyl, hydroxyl, hydroxyalkyl, nitro, NR C R D , and (NR C R D )carbonyl; each R A , R B , R C , and R D is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, and alkylcarbonyl; R 4 , is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, haloalkyl, hydroxyalkyl, and (NR A R B )alkyl; or stereoisomers, and salts thereof.