Patent ID: 6127354
Filing Date: 2000-10-03
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I ##STR200## wherein A is A.sup.2 ;G is G.sup.2 ;D is ##STR201## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently are hydrogen, halogen, aryl, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy;E is ##STR202## wherein R.sup.10 and R.sup.11 independently are hydrogen, halogen, aryl, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, --CONR.sup.15 R.sup.16, --(CH.sub.2).sub.v --NR.sup.15 SO.sub.2 R.sup.17, --(CH.sub.2).sub.v --NR.sup.15 COR.sup.16, --(CH.sub.2).sub.v --OR.sup.17, --(CH.sub.2).sub.v --OCOR.sup.16, --CH(R.sup.15)R.sup.16, --(CH.sub.2).sub.v --NR.sup.15 --CS--NR.sup.16 R.sup.18 or --(CH.sub.2).sub.v --NR.sup.15 --CO--NR.sup.16 R.sup.18,whereinR.sup.15, or R.sup.16, independently are hydrogen or C.sub.1-6 -alkyl optionally substituted with halogen, --N(R.sup.26)R.sup.27, hydroxyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkoxycarbonyl, C.sub.1-6 -alkyl-carbonyloxy or aryl,R.sup.17 is C.sub.1-6 alkyl or phenyl optionally substituted with hydroxyl or aryl;R.sup.18 is C.sub.1-6 alkyl;R.sup.26 and R.sup.27 are independently hydrogen or C.sub.1-6 -alkyl;v and w are independently 0, 1, 2 or 3;A.sup.2 is ##STR203## wherein R.sup.29, R.sup.33, R.sup.34, R.sup.35 and R.sup.36 are independently hydrogen or C.sub.1-6 -alkyl optionally substituted with halogen, amino, hydroxyl or aryl;R.sup.33 and R.sup.34, R.sup.33 and R.sup.35 or R.sup.34 and R.sup.35 may optionally form --(CH.sub.2).sub.i --Z--(CH.sub.2).sub.j --, wherein i and j independently are 1 or 2 and Z is a valence bond;n, m and q are independently 0, 1, 2, or 3;o and p are independently 0 or 1;M is --CR.sup.37 .dbd.CR.sup.38 -;R.sup.37 and R.sup.38 are independently hydrogen, or C.sub.1-6 -alkyl optionally substituted with aryl;G.sup.2 is hydrogen or C.sub.1-6 -alkyl;R.sup.1 is hydrogen, or C.sub.1-6 -alkyl;R.sup.2 is hydrogen, --C(.dbd.O)--R.sup.54 or C.sub.1-6 -alkyl;R.sup.3 and R.sup.4 may be taken together to form .dbd.S, .dbd.O;L.sup.1 is CR.sup.57 ;L.sup.2 is CR.sup.58 ;R.sup.57 and R.sup.58 independently are hydrogen, C.sub.1-6 -alkyl, optionally substituted with hydroxyl, halogen, C.sub.1-6 -alkoxy, or aryl;a and b independently are 0, 1, 2, or 3;or a pharmaceutically acceptable salt thereof.