Patent ID: 8093230
Filing Date: 2012-01-10
Classification: A61K,A61P

Abstract:
1. A method of preparing an aqueous pharmaceutical preparation comprising a supersaturated Ifosfamide solution, said method comprising: a. cooling about 90% of the required amount of buffered water to a temperature of from about 0° C. to 21° C.; b. dissolving the required amount of Mesna in the cooled, buffered water; c. dissolving an amount of Ifosfamide in said buffered Mesna solution; d. adjusting the resulting solution from steps a-c to a pH of from about 6 to about 8; e. adding the remaining 10% of the required amount of water to the solution; wherein said required amount of Mesna is at least 5 g/100 ml and up to 50 g/100 ml, wherein a final Ifosfamide concentration is greater than 20% (wt/vol.) and up to 50% (wt/vol.), and wherein said solution is free of additional solubility-enhancing agents.