Patent ID: 9005670
Filing Date: 2015-04-14
Classification: A61K,A61N,A61P,C07D,C12Q

Abstract:
1. A method for treating cancer in a subject, the method comprising administering an effective amount of a p300/CBP histone acetyltransferase (HAT) inhibitor selected from the group consisting of a) a compound represented by Formula II: in which X is H, C(O)-Q or S(O) Y is H, halogen, or C(O)-Q; R R Q is OH, O—C or a salt, solvate, or stereoisomer thereof, b) a compound represented by Formula III: in which X is H, C(O)-Q or S(O) Y is H, halogen, or C(O)-Q; R R R Q is OH, O—C or a salt, solvate or stereoisomer thereof; and c) a compound selected from the following compounds: or a salt, solvate, or stereoisomer thereof, to a subject in need thereof, wherein the cancer is selected from the group consisting of leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer, and breast cancer.