Patent ID: 7915425
Filing Date: 2011-03-29
Classification: C07D

Abstract:
1. A process for the preparation of Losartan of the Formula 1: the process comprising: (i) reacting bromo OTBN of the Formula 3: with BCFI of the Formula 4: in the presence of a base and a phase transfer catalyst to form a cyano aldehyde of the Formula 5: (ii) reacting the cyano aldehyde of the Formula 5 with sodium azide in the presence of tributyl tin chloride to form an aldehyde tetrazole of the Formula 8: (iii) reducing the aldehyde tetrazole of the Formula 8 with at least one reducing agent selected from the group consisting of: lithium aluminum hydride, sodium borohydride, and potassium borohydride to form Losartan of the Formula 1.