Patent ID: 6444254
Filing Date: 2002-09-03
Classification: B01J,B05D,B82Y,C07B,C40B,G01N

Abstract:
A method of microstamping a polymer surface with a biological ligand, comprising:introducing a reactive moiety onto the polymer surface to provide a functionalized polymer surface, wherein said step of introducing a reactive moiety onto the polymer surface comprises at least one method selected from the group consisting of hydrolysis, reduction, photoinitiated graft polymerization, aminolysis, forming a surface interpenetrating network of poly(ethylene oxide), chemical reaction at hydroxyl end-groups, corona discharge, reactive plasma etching, laser treatment, and ion beam modification; contacting the functionalized polymer surface having the first reactive moiety thereon with a stamp that has adsorbed onto its surface at least one biological ligand comprising a second reactive moiety, wherein the second reactive moiety of the biological ligand and the first reactive moiety of the functionalized polymer surface form a covalent bond; and then separating the stamp from the functionalized polymer surface, thereby leaving the biological ligand directly and covalently bound to the functionalized polymer surface.