Patent ID: 6221850
Filing Date: 2001-04-24
Classification: A61P,C07H,C12N,C12Q

Abstract:
An oligonucleotide comprising up to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence which specifically binds to a 3'-untranslated region, an open reading frame region, or a translation initiation region of a nucleic acid encoding JNK1 protein (SEQ ID NO: 164), a homolog of JNK1 (SEQ ID NO: 165) or an alpha-2 (SEQ ID NO:166), beta-1 (SEQ ID N:167) or beta-2 (SEQ ID NO:168) isoform thereof, and wherein said oligonucleotide modulates the expression of said JNK1 protein, said JNK1 homolog or said isoform thereof.