Patent ID: 6489102
Filing Date: 2002-12-03
Classification: B01J,B82Y,C40B

Abstract:
A biomolecule or cellular array on a metal substrate, the array produced by a series of steps comprising:(a) depositing an &ohgr;-modified alkanethiol monolayer on a metal substrate; (b) reacting hydrophobic protecting groups with the monolayer; (c) selectively cleaving the &ohgr;-modified alkanethiol monolayer from the metal substrate to yield areas of exposed metal substrate; (d) depositing the same &ohgr;-modified alkanethiol as in step (a) in the areas of exposed metal substrate, thereby yielding an array of discrete, unprotected &ohgr;-modified alkanethiol spots; (e) attaching biomolecules or cells to the discrete, unprotected &ohgr;-modified alkanethiol spots, thereby yielding an array of discrete spots having biomolecules or cells immobilized thereon; (f) removing the protecting groups of step (b); and then (g) making the monolayer resistant to non-specific protein binding.