Patent ID: 6245349
Filing Date: 2001-06-12
Classification: A61K,Y02A,Y10S

Abstract:
A drug delivery composition in concentrate form that contains an antifungal agent and that is dilutable with an aqueous liquid to form an oil-in-water microemulsion containing the antifungal agent in dissolved form, consisting essentially of:(a) from about 3 to about 50 percent by weight phospholipid;(b) from about 3 to about 50 percent by weight propylene glycol, polyethylene glycol having a weight average molecular weight of from 200 to 4000, or mixtures thereof;(c) from about 3 to about 50 percent by weight of high HLB surfactant having an HLB value of at least about 12;(d) from 0 to about 15 percent by weight water; and(e) from about 0.1 to about 50 percent by weight of dissolved antifungal agent comprising Echinocandin B derivatives, clotrimazole, or mixtures thereof;wherein the weight ratio of phospholipid to high HLB surfactant is between 0.1:1 and 3:1.