Patent ID: 6881725
Filing Date: 2005-04-19
Classification: A61K,A61P,Y10S

Abstract:
1. A method of treating pain comprising administering to a subject a pharmaceutical composition comprising an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt, or amide or ester thereof: wherein: X T, W, and V are independently oxygen or sulfur; m=0, 1 or 2; n=0 or 1; p=0, 1, or 2; where the sum of m+n+p is from 0 to 5; each M is independently hydrogen or a pharmaceutically-acceptable inorganic or organic counterion; A=M, or A is a nucleoside residue which is defined as: and is linked to the phosphate chain via the 5′ position of the furanose or carbocycle; Z is H, F or OR Z′ is H, F or OR Y is H, F or OR Y′ is H, F or OR R provided that when A=M, at least one of Y′ and Z′ equals OQ(R further provided that when A is a nucleoside, at least one of Y, Y′, Z, or Z′ equals OQ(R D wherein: Q is a carbon atom; R R R R R wherein R 1 and R 2 and/or R 3 and R 4 are taken together to form Q; Q is a carbon atom; R R R B and B′ are independently a purine or a pyrimidine residue according to Formulas IV or V which is linked to the sugar via the 9- or 1-position, respectively; wherein: R R when R J is carbon or nitrogen, with the provision that when J is nitrogen, R R when present, R R R R wherein: W is oxygen or sulfur; R R R R