Patent ID: 9175308
Filing Date: 2015-11-03
Classification: A61P,C07K,C12N

Abstract:
1. A nucleic acid encoding a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain, and at least one intracellular domain, wherein the intracellular domain includes an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR), the intracellular domain further includes a CD3ζ intracellular domain, and the intracellular domain of GITR is arranged on a C-terminal side relative to the CD3ζ intracellular domain, wherein a T cell or cell population comprising a T cell expressing the chimeric antigen receptor has an increased cytotoxic activity against a cell having the target antigen on the surface, as compared to a T cell or cell population comprising a T cell expressing a chimeric antigen receptor whose intracellular domain consists of an intracellular domain of CD28 and an intracellular domain of CD3ζ.