Patent ID: 8883161
Filing Date: 2014-11-11
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A fusion polypeptide against a tumor caused by an EB virus, the fusion polypeptide comprising: a mutant polypeptide of colicin Ia or Ib which can form ion channels; and a polypeptide of an anti-EB virus antibody or a polypeptide of an anti-EB virus antibody mimetic operably linked with the mutant polypeptide of colicin Ia or Ib which can form ion channels, wherein the mutant polypeptide of colicin Ia or Ib which can form ion channels includes a mutation of amino acid residues G11A, H22G, A26G, V31L, and 40D of wild-type colicin Ia or Ib, wherein the polypeptide of the anti-EB virus antibody has an amino acid sequence identical to an amino acid sequence of a polypeptide of a monoclonal antibody secreted by hybridoma of ATCC HB-168.