Patent ID: 6140323
Filing Date: 2000-10-31
Classification: A61K

Abstract:
In a method for administering medicament to the human body, including the central nervous system, wherein a therapeutically effective amount of said medicament is administered to a human, the improvement comprising the steps of:(a) selecting a medicament that is metabolized into an unwanted or adversive metabolite that is increased by gastrointestinal tract absorption and subsequent portal vein entry to the liver;(b) placing the medicament in a suitable formulation selected from the group consisting of an inhalation administration formulation, a skin administration formulation, and combinations thereof;(c) administering a therapeutically effective amount of the formulation from step (b) so as (i) to bypass the gastrointestinal tract absorption and subsequent portal vein entry to the liver and (ii) thereby to decrease formation of the unwanted metabolite;(d) increasing the ratio of medicament to the unwanted metabolite made available to the human body, including the central nervous system; and(e) utilizing this method over a period of one or more doses to achieve sustained high levels of the medicament relative to the unwanted metabolite.