Patent ID: 7491187
Filing Date: 2009-02-17
Classification: A61M

Abstract:
1. An apparatus comprising: a sensor to produce a signal indicative of glycemia levels in a patient, said patient characterized by a patient profile, a programmable actuator adapted to deliver a blood glucose regulator to said patient at an administration rate and a control system adapted to regulate said administration rate of said blood glucose regulator, wherein a model-based predictive controller based on an adaptive dynamic patient model predicts a future response of said patient's glycemia to said administration rate of said blood glucose regulator as a function of time and compensates effects of external disturbance on said patients' glycemia by adjusting said administration rate of said blood glucose regulator to achieve a status of normoglycemia in said patient, which is a critically ill patient and wherein said adaptive dynamic patient model comprising parameter settings corresponds to a model for which: in an initial phase, the parameter settings are determined based on the patient profile comprising variables including on-admission parameters, which determine the class of the patient, whereby each class is associated with distinct parameters for the model; and after the initial phase, the parameter settings are adapted by the incoming signal to more closely approximate the dynamic behaviour of the glycemia in the patient.