Patent ID: 6762164
Filing Date: 2004-07-13
Classification: A61K,A61P,A61Q,C07K

Abstract:
A method for treating alopecia and promoting hair growth comprising treating a patient in need thereof with a pharmaceutical composition containing a 3-position analog of cyclosporin represented by Formula 3, as an active ingredient: in which MeBmt represents N-methyl-(4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine; Aâ€³ represents L-aminobutyric acid (Abu); Bâ€³ represents a D-amino acid represented by the general formula 1, CH3NHâ€”CH(R)â€”COOHâ€ƒâ€ƒ[General Formula 1]in which, R represents X-Râ€² of the general formula 2 below, â€”Xâ€”Râ€²â€ƒâ€ƒ[General Formula 2]in which, X is oxygen or sulfur, and R is selected from the group consisting of hydrogen, and C1-C6 straight or branched alkyl, alkenyl or alkynyl moieties, substituted or unsubstituted with one or more selected from the group consisting of amino, hydroxy, halo, haloalkyl, ester, alkoxy, cyano, nitro, alkylamino, and dialkylamino, with the proviso that when X is sulfur, Râ€² is methyl, substituted or unsubstituted with one or more selected from the group consisting of amino, hydroxy, halo, haloalyl, ester, alkoxy, cyano, nitro, alklamino, and dialkylamino; MeLeu represents N-methyl-L-leucine Val represents L-valine; Ala represents L-alanine; DAla represents D-alanine; and MeVal represents N-methyl-L-valine.