Patent ID: 9121014
Filing Date: 2015-09-01
Classification: A61K,A61P,C12N,C12Q,C12Y,G01N

Abstract:
1. A plasminogen variant, or a plasmin variant, or a proteolytically active or reversibly inactive derivative of a plasmin wherein: the plasminogen variant, the plasmin variant, or the proteolytically active or reversibly inactive derivative of the plasmin comprises the catalytic domain of a human or a non-human plasmin, wherein if the catalytic domain is that of human plasmin, the catalytic domain comprises a substitution of the amino acid glutamate at position 138 of the human plasmin catalytic domain with a different amino acid, and wherein if the catalytic domain is that of a non-human plasmin, the catalytic domain comprises a substitution of the amino acid residue corresponding to position 138 of the human plasmin catalytic domain in the non-human plasmin catalytic domain with a different amino acid.