Patent ID: 8945609
Filing Date: 2015-02-03
Classification: A61K,A61L,C08B,C08L

Abstract:
1. An aqueous thermosetting neutralized chitosan composition forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., said composition comprising 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized until a pH of 6.7-7.1, under a temperature lower than 5° C. with an hydroxylated base previously cooled to a temperature lower than 5° C., and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and sugar alcohols suitable for pharmaceutical use; wherein the said aqueous composition can be lyophilized into a powder which can be then rehydrated into an aqueous thermosetting composition which still forms a phosphate free, transparent hydrogel at a temperature greater than 5° C. after lyophilization and rehydration.