Patent ID: 6630318
Filing Date: 2003-10-07
Classification: A61K,C07K,C12Q,G01N

Abstract:
A method for prognostic evaluation of a patient suspected of exhibiting breast cancer comprising:(a) determining the concentration of HER2 polypeptide/GRB-7 polypeptide complex present in a biological sample, taken from the patient, suspected of containing oncogenic tissue; (b) comparing the level determined in step (a) to the concentration range of HER2 polypeptide/GRB-7 polypeptide complex known to be present in normal, non-oncogenic tissue of the same type as present in the biological sample; and (c) evaluating the prognosis of said patient based on the comparison in step (b), wherein a high level of HER2 polypeptide/GRB-7 polypeptide complex in step (a) indicates an aggressive form of cancer and therefore a poor prognosis.