Patent ID: 8980319
Filing Date: 2015-03-17
Classification: A61K

Abstract:
1. A solid dosage pharmaceutical composition comprising: (a) a plurality of granules containing a pharmaceutically acceptable salt of oxycodone, wherein the granules are substantially resistant to oxidative degradation of the pharmaceutically acceptable salt of oxycodone; and (b) an additional active ingredient, wherein the granules comprise an interior region substantially comprising the pharmaceutically acceptable salt of oxycodone and an exterior region substantially comprising at least one excipient; wherein the granule contains less than about 0.5% w/w of the total mass of the pharmaceutically acceptable salt of oxycodone of each of any one or more of a degradant selected from 10-hydroxy oxycodone, di-hydroxy oxycodone, and oxycodone N-oxide after being stored for 6 months at 40° C. and 75% relative humidity.