Patent ID: 6646009
Filing Date: 2003-11-11
Classification: A61P,C07C

Abstract:
A compound of the formula: wherein:Q1 and Q2 are independently selected from the group consisting of substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl; R is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C6)alkenyl, (C2-C6)heteroalkyl, (C3-C6)heteroalkenyl, (C2-C6)hydroxyalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted aryl(C1-C3)alkyl, unsubstituted aryl(C1-C3)alkyl, substituted heteroaryl(C1-C3)alkyl and unsubstituted heteroaryl(C1-C3)alkyl; wherein the substituents for the substituted aryl and substituted heteroaryl groups comprising Q1 are independently selected from the group consisting of halogen, (C1-C6)alkyl, (C1-C6)alkoxy, nitro, cyano, carboxy, carboxy(C1-C3)alkoxy, hydroxy, (C2-C6)hydroxyalkyl, phosphonato, amino, (C1-C6)acylamino, sulfamyl, acetoxy, di(C1-C6)alkylamino(C2-C6)alkoxy, trifluoromethyl and â€ƒwherein: X is oxygen or sulfur, R5 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)heteroalkyl, substituted phenyl, and unsubstituted phenyl, and R6 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)heteroalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted aryl(C1-C3)alkyl, unsubstituted aryl-(C1-C3)alkyl and (C1-C6)alkoxycarbonyl(C1-C6)alkylenyl; wherein the substituents for the substituted aryl and substituted heteroaryl groups comprising Q2, and the substituents for the substituted aryl and substituted heteroaryl groups comprising or included with R, R5 and R6, are independently selected from the group consisting of halogen, (C1-C6)alkyl, (C1-C6)alkoxy, nitro, cyano, carboxy, carboxy(C1-C3)alkoxy, hydroxy, (C2-C6)hydroxyalkyl, phosphonato, amino, (C1-C6)acylamino, sulfamyl, acetoxy, di(C1-C6)alkylamino(C2-C6) and trifluoromethyl; provided, that when R is hydrogen: (a) when Q1 is unsubstituted phenyl, Q2 is other than dimethoxyphenyl, 2-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-N,N-dimethylaminophenyl, 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 3-methoxy-4-hydroxyphenyl, unsubstituted phenyl, unsubstituted phenyl, unsubstituted benzodioxyolyl, unsubstituted 1-naphthyl and unsubstituted 2-thienyl; (b) when Q1 is 2,4-dinitrophenyl, Q2 is other than 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 4-bromophenyl, 3,4-dichlorophenyl, unsubstituted phenyl or unsubstituted 1-naphthyl; (c) when Q1 is 3-hydroxyphenyl, Q2 is other than nitrophenyl; (d) when Q1 is 2-methyl-5-hydroxyphenyl, Q2 is other than 4-nitrophenyl; (e) when Q1 is unsubstituted 2-pyridyl, Q2 is other than 3-methoxy-4-hydroxyphenyl; and (f) when Q2 is unsubstituted phenyl, Q1 is other than 2-hydroxyphenyl, 2-aminophenyl, 3,4-dichlorophenyl or unsubstituted 2-pyridil; or a pharmaceutically acceptable salt thereof.