Patent ID: 6525081
Filing Date: 2003-02-25
Classification: C07D

Abstract:
A method for inhibition of osteoclast formation which comprises administering to mammals in need thereof an effective amount of the compound of formula I: whereinR1 is hydrogen, lower alkyl, lower alkoxy, hydroxy lower alkyl, or carboxy lower alkyl and R4 is hydroxy; or R1 and R4 taken together form â€”CR5R6â€”(CH2)mâ€”Oâ€” or â€”CR5R6â€”(CH2)pCH(OH)â€”Oâ€”wherein m is an integer of 1 to 3; p is an integer of 0 to 2; and R5 and R6 are each independently hydrogen, lower alkyl, lower alkoxy, or hydroxy lower alkyl; R2 is hydrogen, lower alkyl, lower alkoxy, hydroxy lower alkyl, or carboxy lower alkyl; and R3 is hydrogen, lower alkyl, cycloalkyl, lower alkoxy, arylalkyloxy, heteroarylalkyloxy, lower alkylcarbonyl, arylcarbonyl, substituted or unsubstituted carbamoyl or a group represented by the formula: â€”(CH2)nâ€”Q wherein Q is hydroxy, substituted or unsubstituted amino, aryl, heteroaryl, hydroxycarbonyl or lower alkyloxycarbonyl; and n is an integer of 0 to 3 or a pharmaceutically acceptable salt or hydrate thereof.