Patent ID: 8889880
Filing Date: 2014-11-18
Classification: A61K,A61P,C07D,C07K,C12P

Abstract:
1. A process for preparing a compound of the formula or a pharmaceutically acceptable salt thereof; wherein Ar R R R R R R n is 1, 2, 3, or 4; wherein the process comprises the step of treating a compound of formula A with triethylsilyl chloride and imidazole in an aprotic solvent, where R or the step of treating a compound of formula B with a base and a compound of the formula ClCH or the steps of a) preparing a compound of formula (E1) where X and b) treating a compound of formula C under reducing conditions in the presence of the compound of formula E1, where R or the step of treating compound D with a hydrolase enzyme, where R or the step of treating the silyl ether of compound F with a non-basic fluoride reagent or the step of treating a compound of formula G with an acylating agent of formula R or the steps of c) forming an active ester intermediate from a compound of formula H and d) reacting the active ester intermediate with a compound of the formula I or a combination thereof.