Patent ID: 6426085
Filing Date: 2002-07-30
Classification: A61K,A61Q,Y10S

Abstract:
A method of treating halitosis caused by bacteria in an oral cavity, comprising administering to the oral cavity a topical oral dosage form selected from the group consisting of chewing gum, chewable tablets, lozenges, troches, toothpastes, gargling gels, mouth rinses, and combinations thereof, wherein the topical oral dosage form comprises a pharmaceutically active agent effective against the bacteria consisting essentially of a bismuth compound selected from the group consisting of colloidal bismuth subcitrate, bismuth subcitrate, bismuth citrate, bismuth salicylate, bismuth subsalicylate, bismuth subnitrate, bismuth subcarbonate, bismuth tartrate, bismuth subgallate, tripotassium dicitrato bismuthate, bismuth aluminate, bismuth polysulfates, bismuth polyhydroxy compounds, alpha-D-glucopyranoside bismuth complex, beta-D-fructofuranosyl-oktakis (hydrogen sulfate) bismuth complex, L-dihydro ascorbyl-tetrakis (hydrogen sulfate) bismuth complex, bismuth ascorbyl sulfate, bismuth subascorbate, bismuth sucrose sulfate, bismuth cyclodextrin sulfate, and combinations thereof; and providing sustained release from the topical oral dosage form into the saliva in the oral cavity for at least 5 minutes of a therapeutically-effective amount of the bismuth compound in a concentration in the saliva of at least 2 &mgr;g/mL.