Patent ID: 7553810
Filing Date: 2009-06-30
Classification: A61K,A61L,B82Y,C12Y

Abstract:
1. A method of reducing lung volume in a subject comprising: providing a glue composition comprising a cross-linking moiety of a heat stabilized glutaraldehyde, a pharmaceutically acceptable carrier, an adhering moiety, and a cross-linkable moiety of an albumin, wherein the cross-linkable moiety is covalently linked to the cross-linking moiety, and wherein the adhering moiety is coupled to the cross-linkable moiety and is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin; administering an effective amount of said glue composition to a localized region of damaged lung tissue of said subject; collapsing a first portion or all of the lung of said subject wherein said first portion comprises said localized region of damaged lung tissue; allowing said adhering moiety to bind to different sites of lung tissue; and re-inflating a second portion of the lung of said subject wherein said second portion does not comprise said damaged lung tissue, thereby reducing lung volume.