Patent ID: 6114505
Filing Date: 2000-09-05
Classification: A61K,C07K

Abstract:
A recombinant mutant hemoglobin-like protein comprising a globin-like subunit which contains at least one mutation that reduces heme loss as compared to wild type hemoglobin A.sub.O, wherein the mutation is selected from the group consisting of:a) a mutation at Gly64(E8) in beta globin, a mutation at Thr39(C4) in alpha globin, a mutation at Gly59(E8) in alpha globin, and a mutation at Ser131(H4) in alpha globin; andb) Ser44(CD3).fwdarw.His in beta globin, Leu106(G8).fwdarw.Ile in beta globin, Leu88(F4).fwdarw.Phe in beta globin, Gly136(H14).fwdarw.Leu in beta globin, Leu83(F4).fwdarw.Phe in alpha globin, and Ser131(H14).fwdarw.Leu in alpha globin.