Patent ID: 7927619
Filing Date: 2011-04-19
Classification: A61F,A61L,A61P

Abstract:
1. A method of preparing a crosslinked hydrophilic, biocompatible hydrated tissue-augmentation compound by reacting together mammalian body tissue, body derived fluids and a prepolymer in a prepolymer-to-water ratio of 3:1 to 1:20, said prepolymer prepared by the steps of: (a) Selecting diols or polyols from oxyethylene-based diols or polyols having an average molecular weight of 3,000 to about 30,000, and (b) Reacting said diols or polyols with an aliphatic or aromatic polyisocyanate at an isocyanate-to-hydroxyl ratio of about 2.0 to about 2.5 so that all of the hydroxyl groups of said diols or polyols are capped with polyisocyanate and the resulting prepolymer has an isocyanate concentration of no more than 0.8 milliequivalents per gram.