Patent ID: 6638934
Filing Date: 2003-10-28
Classification: A61P,C07D

Abstract:
A compound of formula (I): or a stereoisomer or a pharmaceutically acceptable salt form thereof, wherein:R1 is selected from H, C(&boxH;O)R2, C(&boxH;O)OR2, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, C1-6 alkyl substituted with Z, C2-6 alkenyl substituted with Z, C2-6 alkynyl substituted with Z, C3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z; C1-3 alkyl substituted with Y, C2-3 alkenyl substituted with Y, C2-3 alkynyl substituted with Y, C1-6 alkyl substituted with 0-2 R2, C2-6 alkenyl substituted with 0-2 R2, C2-6 alkynyl substituted with 0-2 R2, aryl substituted with 0-2 R2, and 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R2; Y is selected from C3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z; C3-6 cycloalkyl substituted with â€”(C1-3 alkyl)â€”Z, aryl substituted with â€”(C1-3 alkyl)-Z, and 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with â€”(C1-3 alkyl)-Z; Z is selected from H, â€”CH(OH)R2, â€”C(ethylenedioxy)R2, â€”OR2, â€”SR2, â€”NR2R3, â€”C(O) R2, â€”C(O)NR2R3, â€”NR3C(O)R2, â€”C(O)OR2, â€”OC(O)R2, â€”CH(&boxH;NR4)NR2R3, â€”NHC(&boxH;NR4)NR2R3, â€”S(O)R2, â€”S(O)2R2, â€”S(O)2NR2R3, and â€”NR3S(O)2R2; R2, at each occurrence, is independently selected from halo, C1-3 haloalkyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl substituted with 0-5 R42; C3-10 carbocyclic residue substituted with 0-3 R41, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41; R3, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, and C1-4 alkoxy; alternatively, R2 and R3 join to form a 5- or 6-membered ring optionally substituted with â€”Oâ€” or â€”N(R4)â€”; R4, at each occurrence, is independently selected from H and C1-4 alkyl; R4a is H or C1-4 alkyl; R4b is H; alternatively, R4a and R4b are taken together to form &boxH;O or &boxH;S; R5 is H or C1-4 alkyl; R6 is H or C1-4 alkyl; alternatively, R5 and R6 are taken together to form a fused heterocyclic ring of formula: wherein: X is a bond, â€”CH2â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”NR10â€”, â€”CH2CH2â€”, â€”OCH2â€”, â€”SCH2â€”, â€”CH2Oâ€”, â€”CH2Sâ€”, â€”CH2NR10â€”, â€”NR10CH2â€”, â€”NHC(&boxH;O)â€”, or â€”C(&boxH;O)NHâ€”; and n is 1 or 2; R7 and R9, at each occurrence, are independently selected from H, halo, â€”CF3, â€”OCF3, â€”OH, â€”CN, â€”NO2, â€”NR46R47, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, (C1-4 haloalkyl)oxy, C3-10 cycloalkyl substituted with 0-2 R33, C1-4 alkyl substituted with 0-2 R11, C3-10 carbocyclic residue substituted with 0-3 R33, aryl substituted with 0-5 R33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(&boxH;NR14)NR12R13, NHC(&boxH;NR14)NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S (O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R1, and NR12C (O) NHR15; R8 is selected from H, halo, â€”CF3, â€”OCF3, â€”OH, â€”CN, â€”NO2, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, (C1-4 haloalkyl)oxy, C3-10 cycloalkyl substituted with 0-2 R33, C1-4 alkyl substituted with 0-2 R11, C2-4 alkenyl substituted with 0-2 R11, C2-4 alkynyl substituted with 0-1 R11, C3-10 carbocyclic residue substituted with 0-3 R33, aryl substituted with 0-5 R33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(&boxH;NR14)NR12R13, NHC(&boxH;NR14)NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15; R10 is selected from H, C1-4 alkyl substituted with 0-2 R10A, C2-4 alkenyl substituted with 0-2 R10A, C2-4 alkynyl substituted with 0-1 R10A, and C1-4 alkoxy; R10A is selected from C1-4 alkoxy, C3-6 carbocyclic residue substituted with 0-3 R33, phenyl substituted with 0-3 R33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S; substituted with 0-2 R44; R11 is selected from H, halo, â€”CF3, â€”CN, â€”NO2, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, C3-10 cycloalkyl, C3-10 carbocyclic residue substituted with 0-3 R33, aryl substituted with 0-5 R33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(&boxH;NR14)NR12R13, NHC(&boxH;NR14)NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S (O)R12, NR14S (O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C (O) NHR15; R12, at each occurrence, is independently selected from C1-4 alkyl substituted with 0-1 R12a, C2-4 alkenyl substituted with 0-1 R12a, C2-4 alkynyl substituted with 0-1 R12a, C3-6 cycloalkyl substituted with 0-3 R33, aryl substituted with 0-5 R33; C3-10 carbocyclic residue substituted with 0-3 R33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; R12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R33; C3-10 carbocyclic residue substituted with 0-3 R33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl; alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with â€”Oâ€” or â€”N(R14)â€”; alternatively, R12 and R13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R16; R14, at each occurrence, is independently selected from H and C1-4 alkyl; R15, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl; R16, at each occurrence, is independently selected from H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, â€”C(&boxH;O)H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-3 haloalkyl-oxy-, and C1-3 alkyloxy-; R31, at each occurrence, is independently selected from H, OH, halo, CF3, SO2R45, NR46R47, and C1-4 alkyl; R33, at each occurrence, is independently selected from H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, â€”C(&boxH;O)H, phenyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy-, C1-4 alkylthio-, C1-4 alkylâ€”C(&boxH;O)â€”, C1-4 alkylâ€”C(&boxH;O)NHâ€”, C1-4 alkyl-OC(&boxH;O)â€”, C1-4 alkylâ€”C(&boxH;O)Oâ€”, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-; C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, butoxy, â€”SO2R45, â€”NR46R47, NR46R47C(&boxH;O)â€”, or (C1-4 alkyl)CO2â€”; and C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, butoxy, â€”SO2R45, â€”NR46R47, NR46R47C(&boxH;O)â€”, or (C1-4 alkyl)CO2â€”; R41, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, &boxH;O; C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl C1-4 alkyl substituted with 0-1 R43, aryl substituted with 0-3 R42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44; R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, SOR45, SR45, NR46SO2R45, NR46COR45, NR46R47, NO2, CN, CH(&boxH;NH)NH2, NHC(&boxH;NH)NH2, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl, C1-4 alkyl substituted with 0-1 R43, aryl substituted with 0-3 R44 and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44; R43 is C3-6 cycloalkyl or aryl substituted with 0-3 R44; R44, at each occurrence, is independently selected from H, halo, â€”OH, NR46R47, CO2H, SO2R45, â€”CF3, â€”OCF3, â€”CN, â€”NO2, C1-4 alkyl, and C1-4 alkoxy; R45 is C1-4 alkyl; R46, at each occurrence, is independently selected from H and C1-4 alkyl; and R47, at each occurrence, is independently selected from H, C1-4 alkyl, â€”C(&boxH;O)NH(C1-4 alkyl), â€”SO2(C1-4 alkyl), â€”C(&boxH;O)O(C1-4 alkyl), â€”C(&boxH;O) (C1-4 alkyl), and â€”C(&boxH;O)H; provided when R5 is H or C1-4 alkyl; and R6 is H or C1-4 alkyl; then at least one of R7, R8 and R9 must be either 1) an aryl group substituted with 1-5 R33; 2) an arylmethyl-group substituted with 1-5 R33; or 3) â€”NR12R13 wherein R12 is an aryl group substituted with 1-5 R33.