Patent ID: 8021866
Filing Date: 2011-09-20
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A nucleic acid molecule comprising a nucleotide sequence that encodes an ADP-enhanced apyrase or a nucleotide sequence that is the complement thereto, which ADPase enhanced apyrase is a modified form of a soluble form of CD39L3 or a fusion protein of said soluble form with heterologous sequence wherein said modification results in increased ADPase activity; or substantially the same ADPase activity combined with decreased ATPase activity as compared with the native apyrase, wherein the ADPase enhanced apyrase contains two amino acid substitutions; wherein said one of said two amino acid substitutions is either at position 67 or at position 69 of human CD39L3 as set forth in SEQ ID NO:56 in soluble form or positions corresponding thereto in an isoenzyme of human CD39L3 in soluble form, wherein said soluble form of 3 human CD39L3 lacks a 43 amino acid sequence from the N-terminus and lacks a 44 amino acid sequence from the C-terminus of SEQ ID NO:56.