Patent ID: 7670487
Filing Date: 2010-03-02
Classification: B01D,G01N,G05D,Y10T

Abstract:
1. A system for de-pressurization of a separation column containing a mobile phase in a static flow state, comprising: a separation column comprising an inlet flowline connected to a pump, wherein the pump has stopped pumping a mobile phase flow into the column; a valve connected on an outlet flowline of the separation column; an inlet pressure sensor connected to the inlet flowline of the column and an outlet pressure sensor connected to the outlet flowline of the column; a controller, comprising a computer with memory and a processor, operatively connected to the pressure valve, inlet pressure sensor, and outlet pressure sensor, wherein the controller performs: monitoring of an inlet pressure and an outlet pressure of the mobile phase within the column; decreasing the outlet pressure to a pressure setpoint; and maintaining the outlet pressure setpoint for a time period until the inlet pressure decreases to within a range of the outlet pressure setpoint.