Patent ID: 7384944
Filing Date: 2008-06-10
Classification: A61K,A61P,C07D

Abstract:
1. A method treating solid organ transplant rejection, and graft v. host disease, comprising administering to a human in need of such treatment a therapeutically effective amount of a CCR5 antagonist of the structural formula II or a pharmaceutically acceptable salt thereof, wherein (1) R  R R  R  R  R  R —NH 2 , —NHCOCF 3 , —NHCONH(C 1 -C 6 alkyl), —NHCO(C 1 -C 6 alkyl), —NHSO 2 (C 1 -C 6 alkyl), 5-membered heteroaryl and wherein X is —O—, —NH— or —N(CH 3 )—;  R wherein X is as defined above;  R —NHCOCF 3 , 5-membered heteroaryl and wherein X is as defined above;  R  R  R  R  R  R  R (2) R  R  and R