Patent ID: 6582969
Filing Date: 2003-06-24
Classification: B82Y,Y10S,Y10T

Abstract:
A method of screening a plurality of immobilized biological moieties for their ability to interact with one or more components of a fluid sample comprising the steps of:(i) providing a multi-channel sample detection device, said sample detection device comprising: (a) a substrate having an upper surface, (b) a plurality of discrete open channels formed in or on said substrate adjacent said upper surface, each channel extending between first and second ends and having a bottom wall surface defining an immobilization region intermediate said first and second ends, (c) a cover attached to said substrate's upper surface and forming with each channel a closed channel having open first and second ends, said cover being part of a detection system for detecting interactions between said biological moieties and said components of said fluid sample within each channel, (d) one or more of said biological moieties for immobilizing said components of said fluid sample, said biological agents being immobilized by being chemisorbed or physisorbed to said immobilization regions in each channel to form immobilized biological moieties, wherein when said fluid containing said components is introduced into said channels to interact with said immobilized biological moieties, such interactions, if any, can be detected by said detection device; (ii) contacting said fluid with at least one of said channels so that said fluid contacts said immobilized biological moieties within said channel; and, (iii) monitoring said interactions, if any, between said immobilized biological moieties and said components of said fluid.