Patent ID: 6084131
Filing Date: 2000-07-04
Classification: C07C,C07D

Abstract:
A process for preparing a protected dihydroxypropyl trialkylammonium salt, having the formula: ##STR6## wherein R.sub.1 and R.sub.2 are protecting groups which can be combined which comprises:(a) reacting a protected butyramide having the formula: ##STR7## wherein R.sub.1 and R.sub.2 are the same protecting groups which can be combined in a reaction mixture in a Hoffman rearrangement reaction with a base and a halogen to produce a protected 3-amino-1,2-dihydroxypropane having the formula: ##STR8## wherein R.sub.1 and R.sub.2 are the same protecting groups which can be combined; and(b) reacting the protected 3-amino-1,2-dihydroxypropane with a lower alkylating agent in the presence of a base in a solvent for the reaction mixture to produce the protected dihydroxypropyl trialkylammonium salt.