Patent ID: 6831089
Filing Date: 2004-12-14
Classification: A61P,C07D

Abstract:
A compound represented by the structural formula: or a pharmaceutically acceptable salt or solvate of said compound, wherein:Z is N; X is â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”S(O)2â€”, â€”C(O)â€”, or â€”C(S); R3 is 1 to 5 substituents which can be the same or different, each said substituent being either alkoxy or halo; R4 ; R27 is hydrogen or 1 or 2 substituents which can be the same or different, each said substituent being independently selected from the group consisting of alkyl, hydroxyalkyl, arylalkyl, aminoalkyl, haloalkyl, alkylthio, alkylthioalkylenyl, carboxyalkyl, imidazolyalkyl and indolyalkyl; R28 is hydrogen or 1 or 2 substituents which can be the same or different, each said substituent being independently selected from the group consisting of alkyl, hydroxyalkyl, arylalkyl, aminoalkyl, haloalkyl, alkylthio, alkylthioalkylenyl, carboxyalkyl, imidazolyalkyl and indolyalkyl; or R27 and R28 can be joined together to form an alkylene group; R29 is hydrogen, alkyl, â€”C(O)-alkyl, â€”C(O)-cycloalkyl, alkoxycarbonyl, aminocarbonyl, aryloxycarbonyl, alkylaminocarbonyl, alkylsulfonyl, arysulfonyl or â€”SO2â€”NHâ€”R35; R31 is hydrogen or 1 or 2 substituents which can be the same or different, each said substituent being independently selected from the group consisting of alkyl, aryl, cycloalkyl, hydroxyalkyl, aminoalkyl, hydroxy, â€”N(R35)2, â€”O-acyl, â€”N(R35)acyl, â€”OC(O)OR35 and â€”OC(O)N(R35)2; R32 is hydrogen or 1 or 2 substituents which can be the same or different, each said substituent being independently selected from the group consisting of alkyl, aryl, cycloalkyl, hydroxyalkyl, aminoalkyl, hydroxy, â€”N(R35)2, â€”O-acyl, â€”N(R35)acyl, â€”OC(O)OR35 and â€”OC(O)N(R35)2, or R31 and R32 can be joined together to form the group â€”(CH2)râ€”, wherein r is 1, 2, 3, 4, 5 or 6; and R35 is hydrogen, aryl or alkyl.