Patent ID: 6670307
Filing Date: 2003-12-30
Classification: A01N,C07D

Abstract:
A compound of the formula: in whichA is phenyl pyridyl, pyrimidinyl, pyrazinyl, pyrazolyl or thienyl, each of the abovementioned groups are optionally substituted by one or more radicals X; X is identical or different a) halogen, cyano, nitro; b) (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkylthio, (C1-C4)alkylsulfinyl, (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, phenyl, â€ƒthe radicals of group b are optionally substituted by one or more radicals selected from the group consisting of halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4) haloalkoxy; E is a single bond, (C1-C4)alkylene, â€”Oâ€”CH2â€” or â€”CH2â€”Oâ€”; G is a radical selected from the group consisting of: Z is oxygen or sulfur; R1, R2 and R3 are identical or different hydrogen, halogen, (C1-C4)haloalkyl, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy or cyano; R4 is hydrogen or a group (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl, (C4-C10)cycloalkylalkyl, or (C7-C12)phenylalkyl, each of the above-mentioned groups are optionally substituted by one or more substituents from the group consisting of halogen, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C3)haloalkoxy, (C1-C3)alkylthio, (C3-C8)cycloalkyl, (C7-C12)phenylalkoxy, (C2-C4)alkylcarbonyl, alkoxycarbonyl, (C2-C8)monoalkyl- and (C3-C9)dialkylaminocarbonyl, cyano and tri(C1-C4)alkylsilyl; R5 and R6 are identical or different a) hydrogen, halogen, cyano, formyl, (C2-C5)alkylcarbonyl, (C2-C8)alkoxylcarbonyl, (C3-C9)monoalkyl- and dialkylaminocarbonyl; b) (C1-C8)alkyl, (C3-C8)cycloalkyl, (C4-C8)cycloalkenyl, (C1-C8)alkoxyalkyl, (C1-C8)alkylthio, (C1-C8)alkylsulfinyl, (C1-C8)alkylsulfonyl, NR7R8, phenyl, phenoxy, (C7-C12)phenylalkyl, (C7-C12)phenylalkoxy, heterocyclyl, heterocyclyloxy derivatives â€ƒheterocyclyl(C1-C4)alkoxy, (C3-C12)heterocyclylalkyl, each of the group b radicals are optionally substituted by one or more radicals selected from the group consisting of halogen, (C1-C4)alkyl, (C1-C3)haloalkyl, (C1-C3)alkoxy, (C1-C3)haloalkoxy, (C1-C3)alkylthio, NR7R8, alkylcarbonyl(C2-C5), alkoxycarbonyl (C2-C8), monoalkyl- and dialkylaminocarbonyl (C3-C9), cyano and tri(C1-C4)alkylsilyl, c) (C1-C8)alkoxy, which is optionally substituted by one or more radicals selected from the group consisting of halogen, (C1-C3)alkylthio, NR7R8, alkylcarbonyl(C2-C5), alkoxycarbonyl, (C2-C8), monoalkyl- and dialkylaminocarbonyl (C3-C9), cyano and tri(C1-C4)alkylsilyl, d) R5 and R6 together form (C3-C8)alkylene, a (C4-C8)alkenylene, a (C7-C12)phenylalkylene, a (C2-C4)alkyleneoxy, a (C1-C2)alkylenedioxy, a (C2-C4)alkyleneamino or a (C2-C4)alkylenethio ring, R7 and R8 are identical or different a) hydrogen; b) (C1-C8)alkyl, (C3-C8)cycloalkyl, (C7-C12)phenylalkyl, (C1-C6)alkycarbonyl, (C1-C6)alkylsulfonyl which are optionally substituted by one or more radicals selected from the group consisting of halogen, (C1-C4)alkyl, (C1-C3)haloalkyl, (C1-C4)alkoxy, (C1-C3)haloalkoxy, (C1-C3)alkylthio, (C1-C3)alkylamino, (C1-C3)dialkylamino, (C3-C8)cycloalkyl, cyano and tri(C1-C4)alkylsilyl or R7 and R8 together are alkylene(C3-C7), (C3-C7)oxa-, aza- or thiaalkylene, (C3-C7)alkylenecarbonyl or (C3-C7)alkylenesulfonyl â€ƒprovided that when Z is oxygen, either R5 and R6 are heterocyclyl, heterocyclyl derivative, heterocyclyl(C1-C4)alkoxy or (C3-C12) heterocyclyloxy or R7 and R8 together are alkylene (C3-C7), (C3-C2)oxa- aza- or thiaalkylene, (C3-C7)alkylenecarbonyl or (C3-C7)alkylenesulfonyl, and â€ƒwherein the heterocycle in the heterocycle, heterocyclyloxy, heterocyclyl (C1-C4)alkoxy or the (C3-C12) heterocyclylalkyl group is selected from the group consisting of thiophene, furan, pyrrole, thiazole, oxazole, imidazole, isothiazole, isoxazole, pyrazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,3,4-triazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole, 1,2,4-triazole, 1,2,3-triazole, 1,2,3,4-tetrazole, benzo[b]thiophene, benzo[b]furan, indole, benzo[c]thiophene, benzo[c]furan, isoindole, benzoxazole, benzothiazole, benzimidazole, benzisoxazole, benzisothiazole, benzopyrazole, benzothiadiazole, benzotriazole, dibenzofuran, dibenzothiophene, carbazole, pyridine, pyrazine, pyrimidine, pyridazine, 1,3,5-triazine, 1,2,4-triazine, 1,2,4,5-triazine, quinoline, isoquinoline, quinoxaline, quinazoline, cinnoline, 1,8-naphthyridine, 1,5-naphthyridine, 1,6-naphthyridine, 1,7-naphthyridine, phthalazine, pyridopyrimidine, purine, pteridine and 4H-quinolizine.