Patent ID: 6025473
Filing Date: 2000-02-15
Classification: A01K,A61K,C07K,C12N,G01N

Abstract:
An isolated protein which is encoded by a nucleic acid molecule which hybridizes under high stringency conditions, with a wash step in about 0.2.times.SSC at 50.degree. C., to a nucleic acid having the nucleotide sequence shown in SEQ ID NO: 1, wherein the protein confers multidrug resistance, including resistance to at least two drugs selected from the group consisting of anthracyclines, epipodophyllotoxins and Vinca altloids, on a drug sensitive mammalian cell when the protein is expressed in the cell, said multidrug resistance not being substantially reversed by chemosensitizers which reverse P-glycoprotein-mediated multidrug resistance.