Patent ID: 6723843
Filing Date: 2004-04-20
Classification: C07C,C07H

Abstract:
A resin-linker-saccharide support for solid-phase synthesis of oligosaccharides, comprising:(a) a resin; (b) a linker covalently attached to said resin; and (c) one or more saccharide groups covalently attached to said resin via said linker; wherein the support is a compound of formula I in whichR1 is hydrogen or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; Râ€² is an amino sugar, a glycosylamine, or a glycosylamine of an oligosaccharide; a mono or oligosaccharide coupled through an alkyl-, substituted alkyl-, aryl-, substituted aryl-, cycloalkyl-, or substituted cycloalkyl-amino group; or a mono or oligosaccharide coupled through a carboxyalkyl-, substituted carboxyalkyl-, carboxyaryl-, substituted carboxyaryl-, carboxycycloalkyl-, or substituted carboxycycloalkyl-amino group; and Râ€³ is an alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or substituted cycloalkyl spacer group that is directly coupled to the resin support or that is coupled to the resin via a functionality that is stable to conditions of oligosaccharide synthesis and cleavage.