Patent ID: 7875596
Filing Date: 2011-01-25
Classification: A61K,A61L,A61P

Abstract:
1. A method for treating and/or inhibiting heparinoid-induced autoimmune responses, which comprises the steps of: administering to a patient or a medical device an amount of a dermatan sulfate which is therapeutically effective to treat and/or inhibit a heparinoid-induced autoimmune response in the absence of a platelet glycoprotein IIb/IIIa receptor antagonist, the dermatan sulfate comprising repeating disulfated and/or trisulfated disaccharide units of L-iduronic acid and N-acetyl-D-galactosamine and having the following properties: (1) a molecular weight in the range of from about 1200 to about 35,000 Daltons; (2) a sulfur content in the range from about 6 to about 11%; (3) a sulfate/carboxylate ratio (S/C) in the range of from about 1.2 to about 2.0; (4) a combined disulfated and trisulfated disaccharide content in the range of from about 20 to 100%; (5) less than about 20% platelet activation activity in the presence of HIT immune sera or anti-heparin/PF4 antibody; and (6) an ability to inhibit the activation of human platelets caused by HIT reactive sulfated glycosaminoglycans in the presence of either HIT immune sera or anti-heparin/PF4 antibody; and administering to the patient or the medical device an amount of a heparin lyase which is effective to degrade heparin.