Patent ID: 8916531
Filing Date: 2014-12-23
Classification: A61P,C12N

Abstract:
1. A modified antisense compound 12 to 30 nucleobases in length and having a nucleobase sequence that is at least 90% complementary to an equal length portion of the human CD40 gene but not to other sequences throughout the human genome, selected from the following regions of SEQ ID NO: 4: (a) positions 11250-12685, corresponding to intron 6; (b) positions 2943-6367, corresponding to intron 1; (c) positions 6447-6780, corresponding to intron 2; (d) positions 6907-7157, corresponding to intron 3; (e) positions 7305-7673, corresponding to intron 4; (f) positions 7768-11187, corresponding to intron 5; (g) positions 12773-12877, corresponding to intron 7; (h) positions 12907-13429, corresponding to intron 8; and (i) positions 13662-16001, which forms part of exon 9 or a region 3′ to exon 9.