Patent ID: 7976852
Filing Date: 2011-07-12
Classification: A61K,A61P

Abstract:
1. A method for inducing an immune response in a subject individual, the method comprising the steps of: administering to the individual one or more anti-cancer antibodies and administering to the individual a compound of formula (I) wherein: R a and b are each independently 0, 1, 2, 3 or 4; a′ and b′ are independently 2, 3, 4, 5, 6, 7 or 8; d and e are each independently 1, 2, 3, 4, 5 or 6; d′ and e′ are each independently 0, 1, 2, 3 or 4; d″ and e″ are each independently 0, 1, 2, 3 or 4; T is oxygen or sulfur; X W R R R G or G Z R M is independently selected from a hydrogen atom and a pharmaceutically acceptable cation; or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, amorphous solid thereof, or any combination thereof; wherein said immune response results in stabilizing a tumor by preventing or slowing the growth of an existing cancer, preventing the spread of a tumor or of metastases, reducing tumor size, preventing the recurrence of treated cancer, eliminating cancer cells not killed by earlier treatments, or preventing or delaying the development of cancer in said individual; wherein the one or more anti-cancer antibodies is trastuzumab and the compound of formula (I) is ER 804057 and/or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or amorphous solid thereof.