Patent ID: 9078812
Filing Date: 2015-07-14
Classification: A61K,A61P

Abstract:
1. A method for pretreating an individual at risk of having hypersensitivity reactions associated with administration of a reactogenic pharmaceutical composition comprising a drug or a diagnostic agent formulated within an encapsulated particulate vehicle, the method comprising a desensitizing pretreatment, the desensitizing pretreatment comprising administering to the individual a particulate drug-free vehicle prior to the administration of the reactogenic pharmaceutical composition, wherein the drug-free vehicle is the same vehicle as the vehicle of the reactogenic pharmaceutical composition administered to the individual after the desensitizing pretreatment and wherein the hypersensitivity reactions are accompanied by clinical symptoms selected from the group consisting of anaphylaxis, anaphylactoid reactions, pseudoallergy, infusion reactions, and idiosyncratic reactions, or wherein the hypersensitivity reactions comprise complement system activation-related pseudoallergy.