Patent ID: 6307051
Filing Date: 2001-10-23
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR21##wherein:R and R.sup.1 are independently hydrogen, (C.sub.1 -C.sub.6)alkyl, styryl or (C.sub.3 -C.sub.6)cycloalkyl or, taken together with the carbon to which they are linked, form a (C.sub.3 -C.sub.6)cycloalkyl group; ##STR22##T is --CH.sub.2 --C.ident.CH, --C.ident.CH, --(CH.sub.2).sub.p --R.sub.3, --CH.dbd.CH--R.sub.3, --CH.sub.2 --NHCO--R.sub.3, --(CH.sub.2).sub.p --O--R.sub.3, or --CH(NH.sub.2)--CH.sub.2 R.sub.3, wherein p is 0 or an integer from 1 to 4, andR.sub.3 is phenyl, naphthyl, biphenyl, each being unsubstituted or substituted by one or more groups selected from chlorine, bromine, iodine, fluorine, (C.sub.1 -C.sub.6)alkyl, cyano, nitro, mono- or polyfluoroalkyl, --SO.sub.2 (C.sub.1 -C.sub.4)alkyl, --SO.sub.2 NH.sub.2, --SO.sub.2 NH(C.sub.1 -C.sub.4)alkyl, --SO.sub.2 N[(C.sub.1 -C.sub.4)alkyl].sub.2, --CONH.sub.2, --CONH(C.sub.1 -C.sub.4)alkyl, hydroxy, amino, carboxy, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)mono- or di-alkyl amino, (C.sub.1 -C.sub.4)alkoxycarbonyl, mercapto, (C.sub.1 -C.sub.4)alkylthio or R.sub.3 is a 5- or 6-membered unsubstituted or substituted heterocycle which contains 1 or 2 heteroatoms selected from oxygen, sulfur or nitrogen and which is or is not benzocondensed, wherein the substituents are one or more groups selected from chlorine, bromine, iodine, fluorine, (C.sub.1 -C.sub.6)alkyl, cyano, nitro, mono- or polyfluoroalkyl, --SO.sub.2 (C.sub.1 -C.sub.4)alkyl, --SO.sub.2 NH.sub.2, --SO.sub.2 NH(C.sub.1 -C.sub.4)alkyl, --SO.sub.2 N[(C.sub.1 -C.sub.4)alkyl].sub.2, --CONH.sub.2, --CONH(C.sub.1 -C.sub.4)alkyl, hydroxy, amino, carboxy, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)mono- or di-alkyl amino, (C.sub.1 -C.sub.4)alkoxycarbonyl, mercapto, (C.sub.1 -C.sub.4)alkylthio, or an enantiomer, diastereoisomer, racemate or mixture thereof, or a pharmaceutically acceptable salt thereof.