Patent ID: 6369086
Filing Date: 2002-04-09
Classification: A61P,C07D

Abstract:
A compound of formula (I): whereinX is N, CH, CCF3, or C(C1-12 aliphatic); R1 and R2 together with the carbon atoms to which they are bound form a fused thiazole or thiazole optionally substituted by C1-12 aliphatic, halogen, nitro, cyano, C1-12 alkoxy, carbonyl-C1-12 alkoxy or oxo; R3 is hydrogen, C1-12 aliphatic, hydroxy, hydroxy C1-12 aliphatic, di-C1-12 aliphatic amino, di-C1-12 aliphatic aminocarbonyl, di-C1-12 aliphatic aminosulfonyl, C1-12 alkoxy, Aryl, Aryloxy, hydroxy-Aryl, or halogen, where Aryl is as defined below; R4 is R7-sulfonyl, R7-sulfonyl-C1-12 aliphatic, R7-aminosulfonyl, R7-aminosulfonyl-C1-12 aliphatic, R7-sulfonylamino, R7-sulfonylamino-C1-12 aliphatic, (R8)1-3-Arylamino, (R8)1-3-Arylsulfonyl, (R8)1-3-Aryl-aminosulfonyl, (R8)1-3-Aryl-sulfonylamino or pyridyl-amino, where R7, R8, and Aryl are as defined below; R5 is hydrogen; R7 is pyridyl, pyridyl-C1-12-aliphatic, pyridyl-C1-12-alkoxy, di-pyridyl-C1-12-alkoxy Aryl, Aryl-C1-12-aliphatic, Aryl-C1-12-alkoxy, or Aryl-carbonyl, where Aryl is as defined below; R8 is hydrogen, nitro, cyano, C1-12 alkoxy, halo, carbonyl-C1-12 alkoxy or halo-C1-12 aliphatic; Aryl is phenyl, naphthyl, phenanthryl or anthracenyl; and the pharmaceutically acceptable salts, solvates, or prodrugs thereof in either crystalline or amorphous form.