Patent ID: 8980343
Filing Date: 2015-03-17
Classification: A23L,A23V,A61K,A61P,A61Q

Abstract:
1. A plant extract obtained from Morus plant leaves which has an IC 50 value of less than 90 μg/ml with respect to inhibition of α-glucosidase I, comprising: 5-40% (w/w) total imino sugars, as measured by at least one of quantitative HPLC High Performance Liquid Chromatography (HPLC) and liquid chromatography/mass spectrometry (LC-MS), including at least one of 1-deoxynojirimycin (DNJ), fagomine, and N-methyl-DNJ; and 20-70% (w/w) total amino acids, wherein the extract is pale yellow and nearly white and is easily soluble in water; wherein the steps of preparing the plant extract comprise: a. subjecting b. subjecting the crude extract to a column chromatography purification step using a strong acidic cation exchange resin, washing the column with water, eluting the column with an ammonia solution, then collecting the eluent and removing ammonia therefrom.