Patent ID: 7538095
Filing Date: 2009-05-26
Classification: A01K,A61K,A61P,C12N

Abstract:
1. A method to inhibit expression of a target gene in a cell in vitro comprising synthesizing at least two ribonucleic acids (RNAs) in the cell in an amount sufficient to inhibit the expression of a target gene, wherein the at least two RNAs form a double-stranded structure containing separate complementary strands, wherein the first RNA consists essentially of a ribonucleotide sequence which corresponds to a nucleotide sequence of the target gene and the second RNA consists essentially of a ribonucleotide sequence which is complementary to the nucleotide sequence of the target gene, wherein the first and the second ribonucleotide sequences are complementary sequences that hybridize to each other to form said double-stranded structure, and wherein the target gene is an endogenous gene.