Patent ID: 8419936
Filing Date: 2013-04-16
Classification: B01D,G01N,Y10T

Abstract:
1. A system for chromatography, comprising: a first pump for pumping a first relatively incompressible fluid flowstream; a second pump for pumping a second relatively compressible solvent fluid flowstream; mixing device that combines said first and second flowstreams; an injection device that can introduce samples or solutions into any of said flowstreams; a chromatography separation column, downstream of said mixing device and that can receive said combined flowstream; a detector, for detecting a concentration of a constituent in one of said flowstreams; a computer controller, directing certain operations of the system; and a back pressure regulator, located downstream of said column, wherein said back pressure regulator includes a device comprising a nozzle insert with an outlet flow channel that can receive an outlet flow and an inlet flow channel that can receive an inlet flow, and further includes a seat, connected near an end of said insert, inset from said nozzle insert such that said seat can be in fluidic communication with said outlet flow channel.