Patent ID: 9056090
Filing Date: 2015-06-16
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant adenovector comprising: a) an expression cassette encoding an HCV polypeptide, wherein said HCV polypeptide comprises HCV NS3-NS4A-NS4B-NS5A; and b) an adenovirus genome containing an E1 deletion, an E3 deletion, and an optional E4 deletion; provided that said genome encodes: i) a fiber region with an amino acid sequence having an identity of at least 70% to SEQ ID NO: 3 or of at least 80% to SEQ ID NO: 9; ii) a hexon region with an amino acid sequence having an identity of at least 95% to either SEQ ID NO: 5 or 11; and iii) a penton region with an amino acid sequence having an identity of at least 85% to SEQ ID NO: 7,