Patent ID: 7223771
Filing Date: 2007-05-29
Classification: A61P,C07D

Abstract:
1. A compound of the formula I where R1 is hydrogen, 1–4C-alkyl, 3–7C-cycloalkyl, 3–7C-cycloalkyl-1–4C-alkyl, 1–4C-alkoxy, 1–4C-alkoxy-1–4C-alkyl, 1–4C-alkoxycarbonyl, 2–4C-alkenyl, 2–4C-alkynyl, fluoro-1–4C-alkyl or hydroxy-1–4C-alkyl, R2 is hydrogen, 1–4C-alkyl, 3–7C-cycloalkyl, 3–7C-cycloalkyl-1–4C-alkyl, 1–4C-alkoxycarbonyl, hydroxy-1–4C-alkyl, halogen, 2–4C-alkenyl, 2–4C-alkynyl, fluoro-1–4C-alkyl or cyanomethyl, R3 is hydroxy-1–4C-alkyl, 1–4C-alkoxy-1–4C-alkyl, 1–4C-alkoxy-1–4C-alkoxy-1–4C-alkyl, 1–4C-alkoxycarbonyl, fluoro-1–4C-alkoxy-1–4C-alkyl or the radical —CO—NR31R32, Arom is a R4-, R5-, R6- and R7-substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimidazolyl, furanyl, benzofuranyl, thiophenyl benzothiophenyl, thiazolyl, isoxazolyl, pyridinyl, pyrimidinyl, quinolinyl and isoquinolinyl, aryl is phenyl or substituted phenyl having one, two or three identical or different substituents from the group consisting of 1–4C-alkyl, 1–4C-alkoxy, carboxyl, 1–4C-alkoxycarbonyl, halogen, trifluoromethyl, nitro, trifluoromethoxy, hydroxyl and cyano, X is O or NH, or a salt, hydrate, hydrate of a salt, solvate or solvate of a salt thereof.