Patent ID: 6121460
Filing Date: 2000-09-19
Classification: C07D

Abstract:
A process for the preparation of an optically active N-acyl-indoline-2-carboxylic acid in which a mixture of enantiomers of N-acyl-indoline-2-carboxylic acid is contacted with at least one optically active resolving agent and the optically active N-acyl-indoline-2-carboxylic acid is liberated from the resulting diastereomeric salt, wherein the resolving agent comprises at least one compound represented by formula 1 ##STR2## wherein R.sub.1 represents an optionally substituted alkyl group and R.sub.2 an optionally substituted (hetero) aryl group or in which R.sub.1 and R.sub.2 together with the C atoms to which they are bound form an optionally substituted cycloalkyl group with 5-8 C atoms, fused with a (hetero) aryl group.