Patent ID: 6797700
Filing Date: 2004-09-28
Classification: C07K

Abstract:
A compound having the formula: wherein X is H or P3;B is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, aralkyl, alkylaryl and alkylaralkyl; Fâ€² is selected from the group consisting of â€”H, alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, carboxymethyl, 2-carboxyethyl, aminocarbonylmethyl, 2-aminocarbonylmethyl, 4-aminobutyl, 3-aminopropyl, 3-guanidinopropyl, indol-3-methyl, imidazol-3-ylmethyl, cycloalkyl, cycloalkylalkyl, cyclohexylcyclohexylmethyl, 1,2,3,4-tetrahydronaphth-5-ylmethyl, alkyl cycloalkyl, alkyl cycloalkylalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, and substituted heterocyclylalkyl, wherein said heterocyclyl is further selected from the group consisting of pyridyl, pyrimidyl and pyrrolidyl; Gâ€² is selected from the group consisting of alkyl, alkyl mono-substituted with aryl or substituted aryl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, OR1, and NR1R2, wherein R1 and R2 are independently selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, aralkyl, alkylaryl, and alkylaralkyl, and said heterocyclyl is further selected from the group consisting of pyridyl, pyrimidyl and pyrrolidyl; p is 1 to 4; P2 is a carboxylic acid protecting group; and P3 is an amino protecting group.