Patent ID: 6706747
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A method for treating a mammal having a disease state selected from the group consisting of elevated intraocular pressure, depression, non insulin-dependent diabetes, male impotence and obesity which is alleviated by treatment with an &agr;2 blocking agent, which comprises administering a therapeutically effective amount of a compound of the formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is oxygen or sulfur; R is hydrogen or branched chain alkyl of 1 to 6 carbon atoms, or straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof.