Patent ID: 6635769
Filing Date: 2003-10-21
Classification: C07D,C40B

Abstract:
A process for making functionalized oxazolidinones having the structure: wherein:(a) R1 is selected from the group consisting of hydrogen, alkyl, and aryl; (b) R2 is alkyl substituted with aryl; (c) R3 is R6 when R6 is selected from the group consisting of primary and secondary alkyl; (d) R4 is aryl; and (e) R5 is alkyl or aryl; the process comprising a reaction step carried out in a reaction mixture, wherein an oxazolidinone having the structure: is reacted with an electrophile selected from the group consisting of R6-Br and R6-I; the reaction mixture comprising a non-protic and non-oxidizing solvent and potassium fluoride on alumina; and without the presence of a substantial amount of a strong base in the reaction mixture.