Patent ID: 7741448
Filing Date: 2010-06-22
Classification: A61P,C07K,G01N

Abstract:
1. An isolated antibody comprising a combination of a heavy chain variable region and a light chain variable region selected from the group consisting of (a) a combination of a heavy chain variable region having an amino acid sequence of SEQ ID NO: 17 and having a CDR including a heavy chain CDR1 having an amino acid sequence of SEQ ID NO: 18, a heavy chain CDR2 having an amino acid sequence of SEQ ID NO: 19, and a heavy chain CDR3 having an amino acid sequence of SEQ ID NO: 20, and a light chain variable region having an amino acid sequence of SEQ ID NO: 21 and having a CDR including CDR1 having an amino acid sequence of SEQ ID NO: 22, CDR2 having an amino acid sequence of SEQ ID NO: 23, and CDR3 having an amino acid sequence of SEQ ID NO: 24; and wherein the antibody recognizes GM1 ganglioside-bound amyloid β-protein.