Patent ID: 7749504
Filing Date: 2010-07-06
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of inhibiting growth—or inducing death of a cancer cell, the method comprising contacting the cell with an isolated monoclonal antibody that binds to: (a) the polypeptide shown in (b) a polypeptide encoded by the nucleotide sequence of SEQ ID NO:37; or (c) a polypeptide encoded by the full-length coding region of the nucleotide sequence SEQ ID NO:37, wherein the isolated monoclonal antibody competes for binding to the epitopes of SEQ ID NO:115 recognized by an antibody produced by the hybridoma selected from the group consisting of 3B5.1 (ATCC Accession No. PTA-6193), 12B9.1 (ATCC Accession No. PTA-6194) and 12G12.1 (ATCC Accession No. PTA-6195).