Patent ID: 8053442
Filing Date: 2011-11-08
Classification: A61P,C07D,Y02A

Abstract:
1. A method of treating or preventing a Plasmodium infection, comprising administering to a patient in need thereof an effective amount of a compound of formula (III): wherein m is 1 or 2; R1 is H, halogen, alkyl, haloalkyl, alkoxy, amine or aryl optionally substituted with one or more substituents; R2 is H, alkyl, arylalkyl or alkoxycarbonyl; R3 is H or alkyl; R4 is H, alkyl, hydroxyalkyl, —COOD wherein D is an alkyl group or R3 and R4 form part of a heterocyclo ring; R5 is H or alkyl; n is 1, 2 or 3; and A and B are fused to and form part of an unsubstituted or substituted monocyclic or polycyclic arene or heteroarene, or a pharmaceutically acceptable salt or ester thereof.