Patent ID: 6861060
Filing Date: 2005-03-01
Classification: A61K,Y10S

Abstract:
1. A formulation for application to a mucosal tissue, the formulation comprising: (a) a biologically active agent wherein said biologically active agent is an antibiotic selected from the group consisting of 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-,alpha,-L-ribo-hexopyranosyl)oxy]-11 12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]], [4-S-(4-alpha,4a-alpha,5a-alpha,6-beta,12a-alpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6-11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11 dioxo-2-naphthacenecarboxamide, and D-threo-N-dichloracetyl-1-p-nitrophenyl-2-amino-1,3-propanediol; D-)-(threo-2-dichloroacetamido-1-p-nitrophenyl-1,3-propanediol; (b) a lipid carrier, said lipid carrier having the property of adhesion capacity to mucosal tissue, said lipid carrier including at least one lipid selected from the group of amphiphilic phospholipids consisting of yolk lecithin, Soya lecithin phosphatidylglycerol and analogs thereof said lipid being characterized as mixed micelles dispersed in an aqueous medium, and said lipid and said biologically active agent being present in a ratio of from about 10:1 to about 1:10.