Patent ID: 6503907
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of:compounds of formula (I) whereinthe bond  between the carbon atom Ca and the carbon atom Cb is a single or a double bond, U is O or a lone pair, V is a) O, S, NR1, or CH2, and L is lower-alkylene or lower-alkenylene or b) â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”, and L is lower-alkylene or a single bond, n is 0 to 7, X is hydrogen or one or more optional halogen and/or lower-alkyl substituents, A1 is hydrogen, lower-alkenyl, or lower-alkyl optionally substituted by hydroxy, lower-alkoxy, or thio-lower-alkoxy, A2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkinyl, heterocyclyl, or lower-alkyl optionally substituted by hydroxy, lower-alkoxy or thio-lower-alkoxy, A3 and A4 independently from each other are hydrogen or lower-alkyl, or A1 and A2 or A1 and A3 are bonded to each other to form a ring and â€”A1â€”A2â€” or â€”A1â€”A3â€” are lower-alkylene or lower-alkenylene, optionally substituted by R2, in which one â€”CH2â€” group of â€”A1â€”A2â€” or â€”A1â€”A3â€” can optionally be replaced by NR3, S, or O, A5 and A6 independently from each other are hydrogen or lower-alkyl, A7 is alkyl with two or more carbon atoms, alkenyl, alkadienyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl, or aryl-lower-alkyl, R2 is hydroxy, lower-alkoxy, thio-lower-alkoxy, N(R4,R5), or lower-alkyl optionally substituted by hydroxy, R1, R3, R4 and R5 independently from each other are hydrogen or lower-alkyl; pharmaceutically acceptable salts of compounds of formula (I);and pharmaceutically acceptable esters of compounds of formula (I).