Patent ID: 7605139
Filing Date: 2009-10-20
Classification: A61K

Abstract:
1. A DNA cancer vaccine comprising a plasmid vector comprising: a) a polynucleotide sequence encoding at least two mycobacterial antigens operably linked to transcription regulatory elements, wherein the two mycobacterial antigens are recombinant BCG antigens of ESAT6; and b) an antigen selected from the group consisting of 85A, 85B, Mpt64, and PstS3, and; c) an additional polynucleotide sequence encoding an Immunoglobulin kappa (IgK) chain leader sequence that is operably linked to said polynucleotide sequence encoding at least two mycobacterial antigens; wherein upon administration to a mammal, said DNA cancer vaccine can effectively attenuate or suppress the growth of bladder cancer cells.