Patent ID: 6214384
Filing Date: 2001-04-10
Classification: A61K

Abstract:
A discontinuous process for the preparation of microspheres having a mean diameter of between 0.1 and 1.mu. and comprising a biocompatible polysaccharide, said process comprising the following steps:a) dissolving the polysaccharide biocompatible polymer in an aprotic solvent at concentrations ranging from 0.1 to 5% by weight,b) charging the solution of step (a) in a pressure proof container having at the top and at the base steel filters with an average cut-off lower than 0.1 .mu.;c) loading the antisolvent from underneath until the pressure at which the fluid becomes supercritical at a temperature ranging from 25.degree. to 60.degree. C. is reached,d) removing the aprotic solvent with a flow of said supercritical fluid,e) depressurizing the pressure proof container, and collecting the precipitated product.