Patent ID: 6436998
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
Method of treating drug addiction and alcoholism which comprises administering an effective amount of amides of &ggr;-hydroxybutyric acid (GHB) of formula (1) whereR1 is a mono- or polycyclic aromatic group, containing one or more carbocyclic or heterocyclic aromatic rings or mixtures thereof, having 5 to 7 atoms in the ring, said rings being optionally subsituted with one or more groups selected from the group consisting of C1-C8 alkyl, C1-C8 alkoxyl, aminic, C1-C8 mono- or dialkylaminic groups, and halogen, where said C1-C8 alkyl and C1-C8 alkoxyl groups may contain or be substituted with one or more double or triple bonds, or with one or more halogen groups; R2 is selected from the group consisting of H; a linear or branched C1-C6 alkyl substituted with one or more double or triple bonds, or with one or more aromatic groups; Q is selected from the group consisting of H and a linear or branched alkyl having 1 to 6 carbon atoms; n is an integer from 1 to 4; T1 and T2 individually, are selected from the group consisting of H and a linear or branched alkyl radical having 1 to 6 carbon atoms.