Patent ID: 6017729
Filing Date: 2000-01-25
Classification: A61K,A61P,C07K,C12Q

Abstract:
An isolated DNA selected from the group consisting of:(a) a DNA encoding a protein comprising amino acids x through 616 of SEQ ID NO:6, wherein x is selected from the group consisting of amino acid 1 and any one of amino acids 24 through 33 of SEQ ID NO:6;(b) a DNA encoding a protein comprising amino acids x through 625 of SEQ ID NO:15, wherein x is selected from the group consisting of amino acid 1 and any one of amino acids 25 through 35 of SEQ ID NO:15;(c) DNA encoding a polypeptide comprising amino acids x through y of SEQ ID NO:6, wherein x is selected from the group consisting of amino acid 1 and any one of amino acids 24 through 33 of SEQ ID NO:6, and y is selected from the group consisting of any one of amino acids 196 through 213;(d) DNA encoding a polypeptide comprising amino acids x through y of SEQ ID NO:15, wherein x is selected from the group consisting of amino acid 1 and any one of amino acids 25 through 35 of SEQ ID NO:15, and y is selected from the group consisting of any one of amino acids 197 through 214; and(e) DNA molecules encoding fragments of proteins encoded by the DNA of (a)-(d), wherein the fragment is capable of binding RANKL or binding a TRAF.