Patent ID: 6469041
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof whereinAr is phenyl, 1- or 2- naphthyl, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl, 4- or 5-pyrimidinyl, each of which is mono-, di-, or trisubstituted with halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy with the proviso that at least one of the positions on Ar ortho to the point of attachment to the pyrazole ring is substituted; R1 is hydrogen or C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl, or C1-C6 alkenyl; Z is a group of the formula whereR4 is hydrogen, C1-C6 alkyl, or (C1-C6) alkyl-W-R8, where W is O, S, NH, or N(C1-C6)alkyl, and R8 is hydrogen or C1-C6 alkyl; m is 0, 1 or 2; n is 0, 1 or 2; and E represents CHR5 where R5 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, or trifluoromethyl, phenyl, naphthyl, pyridinyl, pyrimidinyl, thienyl, imidazolyl, pyrrolyl, pyrazolyl, pyrazinyl, or a saturated 5- or 6- membered ring or a partially unsaturated ring having one or two double bonds; orE is a group of the formula whereR3 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, or trifluoromethyl; and the B ring is phenyl, naphthyl, pyridinyl, pyrimidinyl, thienyl, imidazolyl, pyrrolyl, pyrazolyl, pyrazinyl, or a saturated 5- or 6- membered ring or a partially unsaturated ring having one or two double bonds; or Z is â€”NR6R7 where R6 and R7 are the same or different and representhydrogen, C1-C6 alkyl, (C1-C6)alkyl-Y-R9, wherein Y is O, S, NH, N(C1-C6 alkyl), and R9 is hydrogen or C1-C6 alkyl; or aryl(C1-C6)alkyl, wherein aryl is phenyl, 1- or 2-naphthyl, 2-, 3-, or 4 pyridinyl, 2- or 3-thienyl or 2-, 4, or 5- pyrimidinyl, each of which is mono- or disubstituted with halogen, hydroxy, (C1-C6)alkyl, (C1-C6) alkoxy; or R6 and R7 taken together represent â€”â€”(CH2)nâ€”Yâ€”(CH2)mâ€”wherein n is 2, or 3, Y is CH2, O, S or NR6, wherein R6, is C1-C6 alkyl, phenyl, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl, or 2-, 4-, or 5-pyrimidinyl, and m is 1, 2 or 3.