Patent ID: 8759327
Filing Date: 2014-06-24
Classification: A61P,C07C,C07H,G01N

Abstract:
1. A method of increasing circulating high density lipoprotein (HDL) in a subject, comprising administering to said subject a plasminogen activator inhibitor-1 (PAI-1) inhibitor selected from the group consisting of any compound of Formulas XXII, XXVII, XXIX, XXXIV, XXXI, XXXII, and XXXIII in an amount effective to increase HDL: wherein: n=1 to 5; R R wherein: n=1 to 5; R X R is C wherein: n=0 to 6; X Y Z R is C wherein: n=0 to 5; X Y Z R is C wherein: n=1 to 6; X Y Z R is C wherein: n=0 to 5; X Y R is C wherein: n=0 to 5; X Y R is C