Patent ID: 6518293
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is hydrogen, alkyl, cycloalkyl, aryl or alkyl substituted with optionally substituted phenyl; R2 is hydrogen, alkenyl, alkyl or alkyl substituted with optionally substituted phenyl; R3 is alkyl, cycloalkyl, optionally substituted phenyl, optionally substituted benzyl or heterocyclyl; A is alkyl, hydroxy-alkyl, alkenyl, substituted alkenyl, aryl-CH(OH)â€”, substituted alkyl, or A is a group of formula Zâ€”CH2â€”Yâ€”CH2â€”, â€ƒwherein Y is O or NR wherein R is hydrogen or alkyl and Z is heterocyclyl or optionally substituted aryl; X is S or O; with the proviso that (i) only one of R1 and R2 is hydrogen; (ii) when X is O, then R1 cannot be aryl; is hydrogen;or the pharmaceutically acceptable hydrolyzable esters or the pharmaceutically acceptable salts thereof.