Patent ID: 6177060
Filing Date: 2001-01-23
Classification: A61K,A61P,C07C,C07D,C07K,Y10S

Abstract:
A method for contrast enhanced NMR or x-ray lymphography imaging in a human or animal which comprises administering a contrast enhancement effective amount of a contrast agent to the human or animal and generating an enhanced image by NMR or x-ray of at least a part of the lymphatic system thereof, wherein said contrast agent is a nitrogen-containing cascade polymer, said polymer consisting essentially of:a) a complexing ligand of general formula IA--{X--[Y--(Z--<W--K.sub.w >.sub.z).sub.y ].sub.x }.sub.a (I)in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent,a stands for numbers 2 to 12,x, y, z, and w, independently of one another, stand for numbers 1 to 4,provided that at least two cascade reproduction units are different and that for the product of the multiplicities,16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w .ltoreq.64holds true,b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83,c) optionally one or more cations of inorganic and/or organic bases, amino acids or amino acid amides, andd) optionally, one or more acylated terminal amino groups.