Patent ID: 6916476
Filing Date: 2005-07-12
Classification: A61K,A61P

Abstract:
1. A composition which comprises: (a) a conjugate of (i) a derivative of a ganglioside, which ganglioside comprises an unaltered sphingosine base, wherein the derivative differs from the ganglioside solely by having an altered sphingosine base which retains only C1 through C4 from the unaltered sphingosine base of the ganglioside, and (ii) Keyhole Limpet Hemocyanin, wherein the derivative is covalently bound to Keyhole Limpet Hemocyanin by a stable amine bond between the C-4 carbon of the altered sphingosine base and a nitrogen of an ε-aminolysyl group of Keyhole Limpet Hemocyanin; (b) QS-21; and (c) a pharmaceutically acceptable carrier, wherein the amount of the conjugated derivative is an amount between about 1 μg and about 200 μg, the amount of QS-21 is an amount between about 10 μg and about 200 μg, the ganglioside derivative:Keyhole Limpet Hemocyanin molar ratio is from 200:1 to 1400:1, and the relative amounts of such conjugate and QS-21 is effective to stimulate or enhance production in an subject of an antibody to the ganglioside.