Patent ID: 8071752
Filing Date: 2011-12-06
Classification: A61P,C12N,G16B,G16C

Abstract:
1. A multi-targeting siRNA that targets two different desired mRNA target sequences, wherein the siRNA comprises a first strand having a 5′ terminus and a 3′ terminus and a second strand having a 5 ′ terminus and a 3′ terminus, wherein the first strand is 19-30 nucleotides in length, wherein the second strand is 19-30 nucleotides in length, wherein the first strand is perfectly complementary to a first desired mRNA target sequence, wherein the second strand is perfectly complementary to a second and different desired mRNA target sequence, wherein the first strand and second strand are not completely complementary and wherein the first strand and the second strand hybridize to form a double stranded siRNA, wherein the double stranded siRNA is a single duplex, wherein the first strand has the sequence 5′ uagacacgcaaggagacaugccucuag 3′ (SEQ ID NO:27) and the second strand has the sequence 5′ cugggcuucuuuccuugggugaauaga 3′ (SEQ ID NO:28).