Patent ID: 6214345
Filing Date: 2001-04-10
Classification: A61K,A61P,C07K

Abstract:
A compound of the Formula (I): ##STR75##in whichL is a ligand, wherein L is capable of specifically targeting a selected cell population;A is a carboxylic acyl unit;Y is an amino acid;Z is an amino acid;X and W are each a self-immolative spacer;D is a drug moiety having pendant to the backbone thereof a chemically reactive functional group, said functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulflydryl, carboxyl, aldehyde and a ketone;n is an integer of 0 or 1, with the proviso that n cannot be the integer 0 for both Xn and Wn; andm is an integer of 1, 2, 3, 4, 5 or 6;and wherein Y and Z comprise a protein peptide sequence which is selectively enzymatically cleavable by tumor associated proteases.