Patent ID: 8367039
Filing Date: 2013-02-05
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A compound of general formula (I) below: in which: Signal is a signal entity; Linker, which is absent or is a chemical bond, and Peptide is a peptide comprising a VCAM-targeting peptide, the VCAM-targeting peptide defined below: X10-X11-X12-X13-X14-X15-X16-X17-X18 (SEQ ID No. 4) with: and the pharmaceutically acceptable salts of a), wherein the signal entity is selected from the group consisting of: (1) a chelate coupled to a paramagnetic metal; (2) a metal nanoparticle; and (3) a lipid nanoparticle coupled to a paramagnetic chelate, and (4) a chelate coupled to a radionuclide selected from the radioactive forms of elements consisting of Sm, Ho, Y, Pm, Gd, La, Lu, Yb, Sc, Pr, Tc, Re, Ru, Rh, Pd, Pt, Cu, Au, Ga, In, Sn, Cr, and P.