Patent ID: 7045315
Filing Date: 2006-05-16
Classification: A61K,A61P

Abstract:
1. A method for modulating the expression of an exogenous gene in an isolated cell containing: (i) a DNA construct comprising said exogenous gene operatively associated with a response element, (ii) an ecdysone receptor obtained from a wild-type ecdysone receptor, which ecdysone receptor, in the presence of RXR, is capable of binding to said response element, wherein said ecdysone receptor comprises: wherein at least one of said DNA-binding domain or said activation domain is not obtained from a native ecdysone receptor, and (iii) RXR; said method comprising providing to said cell an effective amount of a first ligand and a second ligand, wherein said first ligand is: wherein said second ligand is a ligand for RXR.