Patent ID: 6197798
Filing Date: 2001-03-06
Classification: A61K,C07C,C07D

Abstract:
A compound of the formula ##STR380##whereinR.sub.2 --C, R.sub.3 --C, R.sub.4 --C or R.sub.5 --C may be replaced by N;and wherein n is 1, 2 or 3;R.sub.1 is aryl, cycloalkyl or heterocyclyl;R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen, alkyl, substituted alkyl, halo, amino, substituted amino, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aralkoxycarbonyl, (alkyl, aryl or aralkyl)-thio, (alkyl, aryl or aralkyl)-oxy, acyloxy, (alkyl, aryl or aralkyl)-aminocarbonyloxy; or any two of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 at adjacent positions are alkylenedioxy;R.sub.6 is amino, substituted amino, acylamino, ##STR381##whereinR.sub.a is hydrogen or optionally substituted alkyl,R.sub.b and R.sub.c are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; or R.sub.b and R.sub.c together represent lower alkylene or lower alkylene interrupted by O, S, or N--(H, alkyl or aralkyl);R.sub.d is optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; andR.sub.e is optionally substituted alkyl, aryl, heterocyclyl, cycloalkyl, amino or substituted amino; the variable R.sub.6 being located on the 5-, 6- or 7-membered saturated ring at a position not directly adjacent to the ring junction;or a pharmaceutically acceptable salt thereof; or an enantiomer thereof.