Patent ID: 7598225
Filing Date: 2009-10-06
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for generating a cytotoxic T-cell eliciting immune response to prostate-specific antigen (PSA) in a human host, comprising administering to the host a first pox virus vector to stimulate an immune response, wherein the first pox virus vector has at least one insertion site containing a DNA segment encoding PSA or a cytotoxic T-cell eliciting epitope thereof operably linked to a promoter such that the DNA segment is expressed to produce PSA or the cytotoxic T-cell eliciting epitope thereof in the host in a sufficient amount to generate a cytotoxic T-cell eliciting immune response, and then administering an additional PSA or T-cell eliciting epitope thereof in a manner selected from the group consisting of in a second pox virus vector, in a formulation with an adjuvant, with a cytokine, with a co-stimulatory molecule, in a liposomal formulation, and a combination thereof.