Patent ID: 8617884
Filing Date: 2013-12-31
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation from a mixed population of T cells from an individual, comprising, exposing a population of cells comprising the mixed population of T cells to a surface, said exposure comprising contacting said population of cells with said surface at a ratio of surface to cells of at least 5:1, wherein the surface has attached thereto an anti-CD3 antibody and an anti-CD28 antibody, or antigen-binding fragments thereof; and wherein said exposure results in apoptosis or growth inhibition in at least a substantial portion of at least one clonal antigen-specific memory T cell population present in the mixed population of T cells without requiring further activation or stimulation; thereby eliminating at least a substantial portion of said clonal antigen-specific memory T cell population from the mixed population of T cells.