Patent ID: 6150505
Filing Date: 2000-11-21
Classification: A61F,A61K,A61L,A61P,C07K,C12M,C12N

Abstract:
A method for producing fibrin microbeads in the absence of glutaraldehyde as a cross linking agent, said method comprising the sequential steps of: (i) preparing an aqueous solution comprising fibrinogen, thrombin and Factor XIII; (ii) prior to the onset of coagulation, contacting said aqueous solution with an oil heated to a temperature of about 50-80.degree. C. to form an emulsion; (iii) mixing the emulsion at a temperature of about 50-80.degree. C. until fibrin microbeads comprising extensively cross-linked fibrin(ogen) are obtained; and (iv) isolating the fibrin microbeads.