Patent ID: 7189198
Filing Date: 2007-03-13
Classification: A61K,A61M

Abstract:
1. A method of delivering a substance to targeted tissue comprising the steps of: delivering a plurality of magnetically responsive particles which are carrying the substance and have a hydrophobic coating into the patient's vasculature upstream of the targeted tissue, wherein the particles include a less hydrophobic layer under the hydrophobic layer, wherein the hydrophobic layer is at least partially removable; and further comprising the step of at least partially removing the hydrophobic layer after the particles are at the delivery site to facilitate the release of the substance; and applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.