Patent ID: 6468539
Filing Date: 2002-10-22
Classification: A61K,A61P,C07K,C12N

Abstract:
A method for targeting a chimeric protein into a virion comprising expressing said chimeric protein in trans with respect to the genome of said virion, said chimeric protein comprising a first and second portion,wherein said first portion has a Vpr/Vpx virion incorporation domain which includes the predicted N-terminal alpha helix of the viral protein selected from the group consisting of HIV-1 Vpr, HIV-2 Vpr, HIV-2 Vpx, SIV Vpr and SIV Vpx and said second portion is fused to the C-terminal portion of said first portion; and wherein said virion contains the p6 domain of a Pr55gag precursor protein; wherein the interaction of said Vpr/Vpx virion incorporation domain of said chimeric protein with said p6 domain of Pr55gag of the virion enables the targeting of said chimeric protein into said virion.