Patent ID: 6441165
Filing Date: 2002-08-27
Classification: A61P,C07D

Abstract:
A process for the industrial synthesis of 11-amino-3-chloro-6,11-dihydro-5,5dioxo- 6-methyl-dibenzo[c,f][1,2]thiazepine of Formula (I): and its addition salts, wherein the ketone of Formula (III): is reacted with sodium borohydride, in a two-phase medium (chlorinated solvent selected from chloroform, dichloromethane/aqueous sodium hydroxide solution), in the presence of N-dodecyl-N-methyl-diethanolammonium bromide, to yield the alcohol of Formula (IV): which, as a suspension in a chlorinated solvent selected from chloroform or dichloromethane, is treated with gaseous hydrogen chloride to yield the chloride of Formula (V): which is then, without being isolated, treated with gaseous ammonia, while maintaining the temperature between 25 and 35Â° C., to yield the compound of Formula (I),which is, if desired, converted into an addition salt.