Patent ID: 8445588
Filing Date: 2013-05-21
Classification: A61K,B82Y,C08B

Abstract:
1. A water soluble copolymer, comprising: a first hydrophilic block segment or graft chain that contains cyclodextrin groups in at least a majority of its repeating units; and a second hydrophilic block segment or graft chain covalently linked to the first hydrophilic block segment or graft chain, the second hydrophilic block segment or graft chain containing repeating units other than cyclodextrin groups; the second hydrophilic block segment or graft chain being a polyethylene glycol block segment; wherein a block segment or graft chain of the first hydrophilic block segment or graft chain is different from the second hydrophilic block segment or graft chain; and wherein the first hydrophilic block segment is a polyaspartamide block carrying α-cyclodextrin groups, β-cyclodextrin groups or γ-cyclodextrin groups; the water soluble copolymer having the structure: wherein m=5 to 500, wherein n=1 to 5, wherein k+1=5 to 100 and k≧1>0, and wherein X=5 when the first hydrophilic block segment is the polyaspartamide block carrying α-cyclodextrin groups, X=6 when the first hydrophilic block segment is the polyaspartamide block carrying β-cyclodextrin groups, or X=7 when the first hydrophilic block segment is the polyaspartamide block carrying γ-cyclodextrin groups.