Patent ID: 9144615
Filing Date: 2015-09-29
Classification: A61K,C08G,C08L

Abstract:
1. A conjugate comprising an antibody or antibody fragment connected to a D-carrying polymeric scaffold, the conjugate having Formula (Ib): wherein: PBRM is an antibody or an antibody fragment; each occurrence of D is independently a therapeutic agent having a molecular weight of ≦5 kDa; the D-carrying polymeric scaffold comprises poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) having a molecular weight ranging from about 20 kDa to about 150 kDa; L each occurrence of in is independently a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; and the in between L D1 and D denotes direct or indirect attachment of D to L D1 ; each occurrence of is independently a second linker not yet connected to a PBRM, in which L P2 is a moiety containing a functional group that is yet to form a covalent bond with a functional group of the PBRM, and the between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1 , and each occurrence of the second linker is distinct from each occurrence of the first linker; each occurrence of in is independently a third linker that connects the D-carrying polymeric scaffold to the PBRM in which the terminal attached to L P2 denotes direct or indirect attachment of L P2 to the PBRM upon formation of a covalent bond between a functional group of L P2 and a functional group of the PBRM; and each occurrence of the third linker is distinct from each occurrence of the first linker; m is an integer from 1 to 1100, m m m m the sum of m, m