Patent ID: 7122326
Filing Date: 2006-10-17
Classification: A61P,G01N

Abstract:
1. A method for selecting, identifying or characterizing compounds that inhibit the binding of xanthurenic acid (XA) to proteins that bind XA, comprising: contacting a test compound with brain cell membranes containing proteins which specifically bind XA, wherein said membranes are obtainable by the process comprising the following steps: (a) preparing synaptosomes by brain cells homogenisation to produce a homogenate, and (b) recovering said brain cell membranes from said homogenate; and measuring the inhibition of the binding of xanthurenic acid to said proteins by said test compound, said measuring comprising (1) determining the binding of XA to the brain cell membrane proteins by contacting a labeled XA with brain cell membrane containing said proteins, (2) determining the binding of labeled XA to brain cell membrane proteins in the presence of a test compound, and (3) comparing the binding in (