Patent ID: 6696459
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A method of treating a patient requiring steroid receptor therapy comprising administering to a patient an effective amount of a compound of the formula: wherein:R1 through R3 each independently are hydrogen, a C1-C6 alkyl, optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, or heteroaryl; R4 is hydrogen, a C1-C6 alkyl, or R5C=O, OR6, NR6R7, where R5 is hydrogen, a C1-C6 alkyl, optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, or heteroaryl, and wherein R6 and R7 each independently are hydrogen, a C1-C6 alkyl, optionally substituted allyl, arylmethyl, aryl, or heteroaryl; R9 through R10 each independently are hydrogen, a C1-C6 alkyl, optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, or heteroaryl; R11 is hydrogen, a C1-C6 alkyl, OR6 or optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, or heteroaryl, where R6 has the same definition given above, or R1 and R2, R2 and R3, R1 and R9, R10 and R11, R1 and R10 and/or R11 and R2 when taken together can form a three- to seven-membered ring optionally substituted with hydrogen, F, OR6 or NR6R7, where R6 through R7 have the definitions given above, provided, however, that R1, R2, R10 and R11 cannot form more than two three- to seven-membered rings at a time; Y is O, CHR6 or NR6, where R6 has the same definition given above; and Z is a polycyclic a monocylic or polycyclic aryl or heteroaryl group, optionally substituted at one or more positions with hydrogen, a C1-C6 alkyl, optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, heteroaryl, F, Cl, Br, I, CN, R5C=O, R6R7NC=O, R6OC=O, perfluoroalkyl, haloalkyl, a C1-C6 straight-chain hydroxy alkyl, HOCR5R8, nitro, R6OCH2, R6O, NH2, or R6R7N, where R5 through R7 have the definitions given above and where R8 is hydrogen, a C1-C6 alkyl or optionally substituted allyl, arylmethyl, alkynyl, alkenyl, aryl, or heteroaryl.