Patent ID: 6046203
Filing Date: 2000-04-04
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR229## wherein X is hydrogen, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxymethyleneoxy, aryl(C.sub.1 -C.sub.6)alkoxy, halo, hydroxy, amino, (C.sub.1 -C.sub.6)alkylamino, di(C.sub.1 -C.sub.6)alkylamino, aryl(C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.6)alkanoylamino, aminocarbonyloxy, (C.sub.1 -C.sub.10)alkylaminocarbonyloxy, di(C.sub.1 -C.sub.10)alkylaminocarbonyloxy, tetrahydroisoquinolylcarbonyloxy, aryl(C.sub.1 -C.sub.10)alkylaminocarbonyloxy, (C.sub.1 -C.sub.6)alkoxycarbonyloxy, aryl(C.sub.1 -C.sub.6)alkylcarbonyloxy; with the proviso that when halo is present another substituent is present;R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, arylo[w]xycarbonyl, aryl(C.sub.1 -C.sub.6)alkoxycarbonyl, aminocarbonyl, (C.sub.1 -C.sub.6)alkylaminocarbonyl or di(C.sub.1 -C.sub.6)alkylaminocarbonyl; and ##STR230## R.sup.2 is where R.sup.6 is hydrogen, (C.sub.1 -C.sub.6)alkyl, aryl, aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkylcarbonyl, aryl(C.sub.1 -C.sub.6)alkylcarbonyl or (C.sub.1 -C.sub.6)alkoxycarbonyl; orR.sup.1 and R.sup.2 together with the nitrogen to which they are attached form the ring ##STR231## where R.sup.7 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.3 -C.sub.6)alkynyl, phenyl, aryl(C.sub.1 -C.sub.6)alkyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl or quinolinyl; R.sup.8 and R.sup.9 are independently hydrogen, (C.sub.1 -C.sub.6)alkyl or aryl(C.sub.1 -C.sub.6)alkyl;m is an integer from 2 to 7;n is an integer from 1 to 3;p is an integer from 1 to 3;s is an integer from 0 to 6;and pharmaceutically acceptable addition salts thereof and optical and geometric isomers and racemic mixtures thereof.