Patent ID: 6294688
Filing Date: 2001-09-25
Classification: C07C,C07D,C07F

Abstract:
A method of stereospecifically producing a compound of formula: ##STR44##or its enantiomer ##STR45##wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl and R.sup.2 is a hydroxy protective group, which comprises reacting a compound of formula: ##STR46##or its enantiomer, respectively, ##STR47##wherein R.sup.1 and R.sup.2 are as above and the stereochemistry of both the compound of formula 1AA and the compound of formula 2AA is the same at carbons 1 and 3, respectively, and the stereochemistry of both the compound of formula 1AA* and the compound of formula 2AA* is the same at carbons 1 and 3, respectively, with a fluorinated alcohol having a pK.sub.a lower than about 9, in the presence of a palladium catalyst to yield the compound of formula 2AA or 2AA*, respectively.