Patent ID: 6933303
Filing Date: 2005-08-23
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): wherein R 1 is 1,1′-biphenyl-4-yl; cyclohexyl; 4-bromo, chloro, or fluorophenyl; 2,4-dichlorophenyl; 4-benzyloxyphenyl; 4-(4-carboxy)benzyloxphenyl; cyclopentyl; (E)-2-phenylvinylphenyl; indol-3-yl; 4-hydroxyphenyl; 4-hydroxybenxyl; 1-benxylindol-3-yl; or 1-butylindol-3-yl; R 2 is (a) hydrogen; (b) alkyl; alkenyl; alkynyl; (c) heterocyclyl; cycloalkyl; (d) -alkylene-aryl; -alkenylene-aryl; -alkynylene-aryl; -alkyloxy-aryl, (e) -alkylene-heteroaryl; -alkenylene-heteroaryl; -alkynylene-heteroaryl; -alkoxy-heteroaryl; (f) -alkylene-heterocyclyl; -alkenylene-heterocyclyl; -alkynylene-heterocyclyl or (g) —C(O)—OR R 3 is (a) hydrogen; (b) alkyl; alkenyl; alkynyl; (c) -alkylene-aryl; -alkenylene-aryl; -alkynylene-aryl; (d) -alkylene-heteroaryl; -alkenylene-heteroaryl or -alkynylene-heteroaryl; A 2 is —NR 10 R 11 , or —NR 10 A 4 ; wherein R (a) hydrogen; (b) alkyl; alkenyl; alkynyl; (c) heterocyclyl; cycloalkyl; (d) aryl; heteroaryl; -arylene-aryl; -arylene-heteroaryl; -heteroarylene-aryl; -heteroarylene-heteroaryl; -alkylene-aryl; -alkenylene-aryl; -alkynylene-aryl; -alkyloxy-aryl; -alkylene-heteroaryl, -alkenylene-heteroaryl, -alkynylene-heteroaryl, -alkoxy-heteroaryl, (e) -alkylene-heterocyclyl; -alkenylene-heterocyclyl; -alkynylene-heterocyclyl; (f) -arylene-L (g) —C(O)—OR wherein R wherein A 4 is wherein L L L L wherein R 9 , R 14 , R 15 , R 16 , and R 19 are independently selected from the group consisting of hydrogen, aryl, alkyl, and alkylene-aryl; A 1 is O; S; or NR 20 , where R 20 is: (a) hydrogen; (b) alkyl; (c) alkenyl; alkynyl; helerocyclyl; cycloalkyl; -alkylene-aryl; -alkenylene-aryl; -alkynylene-aryl; -alkyloxy-aryl; -alkylene-heteroaryl; -alkenylene-heteroaryl; -alkynylene-heteroaryl; -alkoxy-heteroaryl; -alkylene-heterocyclyl; -alkenylene-heterocyclyl; -alkynylene-heterocyclyl; (d) -alkylene-C(O)—OR A 3 is —CH 2 —; Ar 1 is, taken together with the double bond in Formula (I), aryl; R 4 , R 5 , and R 6 are independently selected from the group consisting of (a) hydrogen; (b) aryl, heteroaryl; (c) heterocyclyl; cycloalkyl; (d) -alkylene-Y-aryl; -alkenylene-Y-aryl; -alkynlene-Y-aryl; alkylene-Y-heteroaryl, -alkenylene-Y-heteroaryl; -alkynlene-Y-heteroaryl; -alkylene-Y-cycloalkyl; -alkenylene-Y-cycloalkyl; -alkynlene-Y-cycloalkyl; -alkylene-Y-heterocyclyl; -alkenylene-Y-heterocyclyl; alkynlene-Y-heterocyclyl; —Y—H; —Y-alkyl; —Y-aryl; —Y-alkylene-aryl; —Y-alkylene-NR R or a pharmaceutically acceptable salt, or solvate thereof.