Patent ID: 6281226
Filing Date: 2001-08-28
Classification: A61P,C07D

Abstract:
A compound of general formula (IA) or (IB): ##STR10##in which:each of n and m is independently 0, 1 or 2; andX is selected from --O--, --S(O)--, --SO.sub.2 --, --CO.O--, --NH--, --CONH--, --NHCONH-- and a bond; orn is 1 or 2 and m is 2 and X is --S--; andR.sup.1 is vinyl or ethyl;R.sup.2 is optionally substituted quinuclidinyl, azabicyclo[2.2.1]heptyl, azabicyclo[4,3,0]nonyl, azabicyclo[3.2.1]octyl, azabicyclo[3,3,0]octyl, azabicyclo[2.2.2]octyl, azabicyclo[3.2.1]octenyl, azabicyclo[3.3.1]nonyl or azabicyclo[4.4.0]decyl;R.sup.3 is H or OH; orthe moiety R.sup.2 (CH.sub.2).sub.m X(CH.sub.2).sub.n CH.sub.2 COO at position 14 of (IA) or (IB) is replaced by R.sup.a R.sup.b C=CHCOO in which one of R.sup.a and R.sup.b is hydrogen and the other is R.sup.2 or R.sup.a and R.sup.b together form R.sup.2 ; ora pharmaceutically acceptable salt thereof.