Patent ID: 8937218
Filing Date: 2015-01-20
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A transformed soybean plant comprising a gene encoding a modified seed storage protein, wherein said gene encoding the modified seed storage protein comprises a gene encoding an Alzheimer's disease vaccine inserted into one or more variable region(s) of a gene encoding a wild-type seed storage protein such that frameshift does not occur, and wherein said modified seed storage protein is expressed an accumulates in a seed, wherein said Alzheimer's disease vaccine is a β-amyloid antigenic determinant, and wherein said wild-type seed storage protein is an A1aB1b subunit of soybean 11S globulin which comprises the amino acid sequence shown in SEQ ID NO:2 or an amino acid sequence having an identity of not less than 90% to the amino acid sequence shown in SEQ ID NO:2, and wherein at least one of the variable regions encodes amino acid positions 198-216 in wild-type SEQ ID NO:2 prior to said modification.