Patent ID: 6083961
Filing Date: 2000-07-04
Classification: C07D,C07F

Abstract:
A heterocyclic compound of the formula: ##STR12## wherein a group of the formula: ##STR13## is a group of the formula: ##STR14## X is N--R.sup.5, R.sup.1 is lower alkyl, halo(lower)alkyl, lower alkylamino(lower)alkyl, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, lower alkoxy, lower alkylthio, lower alkylamino, acyl(lower)alkyl, acyl, hydroxy, mercapto, aryl or ar(lower)alkyl,R.sup.5 is hydrogen, lower alkyl, halo(lower)alkyl, lower alkylamino(lower)alkyl, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, lower alkoxy, lower alkylthio, lower alkylamino, acyl(lower)alkyl, acyl, aryl or ar(lower)alkyl,R.sup.2 is hydrogen, halogen, lower alkyl or lower alkoxy,R.sup.3 is halogen, lower alkyl or lower alkoxy,R.sup.4 is a group of the formula: ##STR15## in which R.sup.6 is hydrogen or lower alkyl, andR.sup.7 is an amino acid residue substituted with a substituent selected from the group consisting of optionally substituted pyridyl(lower)alkanoyl, pyridyl(lower)alkoxy-ar(lower)alkenoyl, pyridyl-ar(lower)alkenoyl optionally having oxo, pyridyl(lower)alkyl-ar(lower)alkenoyl, pyridyl(lower)alkenyl-ar(lower)alkenoyl, optionally substituted pyridyl(lower)alkanoylamino-ar(lower)alkenoyl, optionally substituted pyridylcarbonylamino-ar(lower)alkenoyl, N-(lower alkanoyl)-N-(pyridyl(lower)alkyl)amino-ar(lower)alkenoyl, N-(lower(pyridylcarbonyl)-N-(lower alkoxy(lower)alkyl)amino-ar(lower)alkenoyl, pyridylureido-ar(lower)alkenoyl, pyridyl(lower)alkylcarbamoyl-ar(lower)-alkenoyl, N-(pyridyl(lower)alkyl)-N-(lower alkyl)carbamoyl-ar(lower alkenoyl, pyridylcarbamoyl-ar(lower)alkenoyl, optionally substituted pyridylcarbonyl-ar(lower)alkenoyl, pyridyl(lower)alkenoyl, pyridyl(lower)alkenyl-pyridyl(lower)alkenoyl, lower alkanoyl-pyridyl(lower)alkenoyl, pyridylthio(lower)alkanoyl, amino-pyridyl(lower)alkenoyl, lower alkylamino-pyridyl(lower)alkenoyl, lower alkanoylamino-pyridyl(lower)alkenoyl in which the pyridyl group may be substituted with lower alkyl or lower alkoxy, lower alkanoylamino(lower)alkanoylamino-pyridyl(lower)alkenoyl, lower alkenoylamino-pyridyl(lower)alkenoyl, pyridyl(lower)alkanoylamino-pyridyl(lower)alkenoyl, pyridylcarbonylamino-pyridyl(lower)alkenoyl which may be substituted with lower alkyl, lower alkoxycarbonyl(lower)alkanoylamino-pyridyl(lower)alkenoyl, lower alkoxy(lower)alkanoylamino-pyridyl(lower)alkenoyl, lower alkylureido-pyridyl(lower)alkenoyl, carboxy-pyridyl(lower)alkenoyl, lower alkoxycarbonyl-pridyl(lower)alkenoyl, lower alkylcarbamoyl-pridyl(lower)alkenoyl, lower alkoxy(lower)alkylcarbamoyl-pyridyl(lower)alkenoyl, hydroxy(lower)alkylcarbamoyl-pyridyl(lower)alkenoyl, pyridylcarbamoyl-pyridyl(lower)alkenoyl, pyridyl(lower)alkylcarbamoyl-pyridyl-(lower)alkenoyl, pyridylcarbonyl-pyridyl(lower)alkenoyl, lower alkenylcarbamoyl-pyridyl(lower)alkenoyl, lower alkenylcarbamoyl-pyridyl(lower)alkenoyl, optionally substituted pyridylcarbonyl, pyridylcarbonyl-arylcarbamoyl, pyridylcarbonylamino-arylcarbamoyl, pridyl(lower)alkanoylamino-arylcarbamoyl, pyridyl-arylcarbamoyl optionally having oxo, pyridylcarbonyl-arylcarbamoyl having lower alkyl, pyridylcarbonyl-arylcarbamoyl having aryl, pyridylcarbonyl-arylcarbamoyl having a pyridyl group, pyridylcarbonyl-arylcarbamoyl having lower alkanoyl, pyridylcarbonyl-arylcarbamoyl having lower alkoxycarbonyl, pyridylcarbonyl-arylcarbamoyl having lower alkylamino, pyridylcarbonyl-arylcarbamoyl having lower alkylcarbamoyl, pyridylcarbamoyl-arylcarbamoyl, N-(pyridyl)-N-(lower alkyl)carbamoyl-arylcarbamoyl, pyridyl(lower)alkylcarbamoyl-arylcarbamoyl, N-(pyridyl(lower)alkyl)-N-(lower alkyl)carbamoyl-arylcarbamoyl, N-(pyridyl(lower)alkyl)-N-(lower alkoxy(lower)alkyl)carbamoyl-arylcarbamoyl, pyridylcarbamoyl, pyridyl(lower)alkylcarbamoyl, amino acid residue substituted with a pyridyl group and amino acid residue substituted with pyridyl(lower)alkyl, andA is lower alkylene,or a salt thereof.