Patent ID: 6268365
Filing Date: 2001-07-31
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR798##wherein:Ring a is phenyl;A is selected from the group consisting of phenyl and naphthyl; wherein said phenyl or naphthyl is optionally linked to Q or N via an alkoxy or lower alkyl linker;Q is >C.dbd.O;B is selected from the group consisting of H; lower alkyl and a nitrogen-protecting group;R is a bond or an alkyl linker;C is --C(C.sub.1 -C.sub.4 alkyl)(C.sub.1 -C.sub.4 alkyl)COOH, NHCOCOOH or CHOHCOOH;D is >C.dbd.O;E is ##STR799##R.sub.1 is alkyl; alkenyl; alkynyl; cycloalkyl or aryl;R.sub.2 and R.sub.3 are each independently selected from the group consisting of H; alkyl; alkoxy; halo; aryl; alkyloxy carbonyl and alkylamino; wherein R.sub.2 and R.sub.3 are the same or different;R.sub.4 is alkyl; alkoxy; aryl or alkylamino;Z is O; S; NH; N-lower alkyl; or Nnitrogenprotecting group:wherein if two optionally substituted ring members R.sub.1 -R.sub.4 are present in adjacent positions on heterocycle E, said adjacent ring members may be linked together to form a fused 6 membered carbocyclic ring which may be aromatic partially unsaturated or fully saturated;and the pharmaceutically acceptable tautomers, salts and esters thereof.