Patent ID: 6897308
Filing Date: 2005-05-24
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a 3-substituted ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one of formula IIB: wherein X represents one of halogen, acyloxy and sulfonyloxy, comprising a hydrogenation of a substituted ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one of formula VB: wherein X is as defined above, in an aqueous inorganic acid medium at a pressure of from atmospheric to 60 psi and at a temperature of from 0° to 100° C. in the presence of a metal catalyst, followed by an isolation of a resulting product.