Patent ID: 8802654
Filing Date: 2014-08-12
Classification: A61P,C07H

Abstract:
1. A compound according to formula (I) wherein R1 is a methyl or ethyl group; R2 is R3, R4 or R8; “X” is O, S, or NH; and “A” is a C3-7 alkanediyl if R2 is R3 and a C2-7 alkanediyl if R2 is R4 or R8, wherein X and R2 are connected to different carbon atoms of said alkanediyl and wherein said different carbon atoms are the carbon atoms in said alkanediyl being most spaced apart; R3 is selected from the group consisting of N(C0-3 alkyl)C(O)R5, OC(O)R5, C(O)N(C0-3 alkyl)R5 and C(O)OR5, wherein R5 is a straight carbon chain comprising 14 to 30 carbon atoms; said carbon chain is saturated or comprises one or more double and/or triple bond(s); furthermore, said carbon chain is unsubstituted or substituted with one or more C1-C5 alkyl groups; R4 is a substituent according to formula (II) wherein “D” is connected to “A”; “D” is selected from the group consisting of N(C0-3 alkyl)C(O), OC(O), C(O)N(C0-3 alkyl), and C(O)O; the integer “m” is 0 (zero) to 3; the integer “n” is 1 to 15; the integer “p” is 0 (zero) to 3; “E” is selected from the group consisting of N(C0-3 alkyl)C(O), OC(O), C(O)N(C0-3 alkyl), and C(O)O; R7 is selected from the group consisting of R5, as defined above, and R6, wherein R6 is a substituent according to formula (III) wherein each R5, independently, is as defined above, and the C2-5 alkanediyl is attached to “E”; and R8 is selected from the group consisting of N(C0-3 alkyl)C(O)R9, OC(O)R9, C(O)N(C0-3 alkyl)R9 and C(O)OR9, wherein R9 is a substituent according to formula (IV) wherein each R5, independently, is as defined above; as an acid in its non-charged protonated form, a pharmaceutically acceptable addition salt, solvate, or solvate of a salt thereof.