Patent ID: 6096773
Filing Date: 2000-08-01
Classification: A61P,C07D

Abstract:
A compound of the structure ##STR4## wherein A is selected from the group consisting of O, S, and NR.sup.5 ; E is selected from the group consisting of CH.sub.2, O, S, and NR.sup.6 ;Q is selected from the group consisting of C(O) and (CH.sub.2).sub.k wherein k is an integer of 0 or 1;J is selected from the group consisting of O, S and NR.sup.8 ;G is selected from the group consisting of O, NH, S, and (CH.sub.2).sub.p wherein p is an integer of 0 or 1;T is selected from the group consisting of C(O) and (CH.sub.2).sub.b wherein b is an integer of from 0 to 3;L is selected from the group consisting of O, NR.sup.7, S, and (CH.sub.2).sub.n wherein n is an integer of 0 or 1;M is selected from the group consisting of C(R.sup.9)(R.sup.10) and (CH.sub.2).sub.u, wherein u is an integer of from 0 to 3;X is selected from the group consisting of CO.sub.2 B, PO.sub.3 H.sub.2, SO.sub.3 H, OPO.sub.3 H.sub.2, C(O)NHC(O)R.sup.11, C(O)NHSO.sub.2 R.sup.12, tetrazolyl and hydrogen;B, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxy, alkoxyalkoxy, cycloalkylalkyl, alkylamino, haloalkyl, alkylaryl, arylalkyl, heterocyclyl, alkylheterocyclyl and heterocyclylalkyl groups;wherein R.sup.2 and R.sup.3 taken together may form a ring;R.sup.4 and R.sup.7 taken together may form a ring;R.sup.9 and R.sup.10 taken together may form a ring;and salts thereof.