Patent ID: 7579354
Filing Date: 2009-08-25
Classification: A61P,C07D,C07F

Abstract:
1. A method of administering a compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject suffering from a condition selected from constriction of afferent arterioles, congestive heart failure, and renal dysfunction; wherein the renal dysfunction is marked by the presence of an abnormal level of adenosine, is associated with diuretic use, or is due to treatment with a chemotherapeutic agent, or wherein the subject suffering from renal dysfunction is in need of a rise in glomerular filtration rate or an increase in sodium excretion; wherein R wherein said alkyl, alkenyl, or alkynyl is either unsubstituted or substituted with one or more substituents selected from the group consisting of hydroxy, alkoxy, amino, alkylamino, dialkylamino, heterocyclyl, acylamino, alkylsulfonylamino, and heterocyclylcarbonylamino; and R wherein the bicyclic or tricyclic group is either unsubstituted or substituted with one or more substituents selected from the group consisting of: R R X Z is selected from the group consisting of a single bond, —O—, —(CH R