Patent ID: 6060469
Filing Date: 2000-05-09
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR50## wherein R.sup.1 represents a halogen atom, a hydroxy group, a C.sub.1-6 alkyl group optionally substituted by one to three fluorine atoms, a C.sub.1-6 alkoxy group optionally substituted by one to three fluorine atoms, or a C.sub.1-6 alkylthio group optionally substituted by one to three fluorine atoms;R.sup.2 represents hydrogen, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;or when R.sup.2 is adjacent to R.sup.1, they may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring which is selected from 2,3-dihydrobenzofuranyl, benzofuranyl, 3,4-dihydro-2H-1-benzopyranyl, 2H-1-benzopyranyl, 1,3-benzodioxolyl, and 1,4-benzodioxanyl;R.sup.3 represents a 5- or 6-membered aromatic heterocyclic group wherein R.sup.3 is selected from pyrrolyl, furanyl, thienyl, pyridinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazolyl, oxadiazolyl, thiadiazolyl, triazinyl, and tetrazolyl, which group is optionally substituted by one or two groups selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, trifluoromethyl, OCF.sub.3, NO.sub.2, CN, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, COR.sup.a, CO.sub.2 R.sup.a, phenyl, --(CH.sub.2).sub.r NR.sup.a R.sup.b, --(CH.sub.2).sub.r NR.sup.a COR.sup.b, --(CH.sub.2).sub.r CONR.sup.a R.sup.b, or CH.sub.2 C(O)R.sup.a, where R.sup.a and R.sup.b are each independently hydrogen or C.sub.1-4 alkyl and r is zero, 1 or 2;or R.sup.7, R.sup.8 and the nitrogen atom to which they are attached form a non-aromatic azabicyclic ring system selected from 5-azabicyclo[2.1.1]hexyl, 5-azabicyclo[2.2.1]heptyl, 6-azabicyclo[3.2.1]octyl, 2-azabicyclo[2.2.2]octyl, 6-azabicyclo[3.2.2]nonyl, 6-azabicyclo[3.3.1]nonyl, 6-azabicyclo[3.3.2]decyl, 7-azabicyclo[4.3.1]decyl, 7-azabicyclo[4.4.1]undecyl and 8-azabicyclo[5.4.1]dodecyl;or Z, R.sup.7 and the nitrogen atom to which they are attached form a heteroaliphatic ring selected from pyrrolidinyl, piperidyl, morpholinyl, thiomorpholinyl and piperazinyl;R.sup.9 and R.sup.10 each independently represent hydrogen, halogen, C.sub.1-6 alkyl, CH.sub.2 OR.sup.d, oxo, CO.sub.2 R.sup.a or CONR.sup.a R.sup.b where R.sup.a and R.sup.b are as previously defined and R.sup.d represents hydrogen, C.sub.1-6 alkyl or phenyl;R.sup.12 represents OR.sup.a, CONR.sup.a R.sup.b or heteroaryl wherein heteroaryl is selected from pyrrolyl, furanyl, thienyl, pyridyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazolyl, oxadiazolyl, thiadiazolyl, triazinyl, and tetrazolyl;R.sup.13 represents H or C.sub.1-6 alkyl;m is zero 1, 2 or 3;n is zero, 1, 2, or 3, with the proviso that the sum total of m+n is 2 or 3;p is zero or 1;q is 2; andwhen m is 1 and n is 1 or 2, the broken line represents an optional double bond;or a pharmaceutically acceptable salt thereof.