Patent ID: 6458817
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound of formula I having the structure wherein,R1 is hydrogen, alkyl of 1-6 carbon atoms, halogen, trifluoromethyl, trifluoromethoxy, alkoxy of 1-6 carbon atoms, hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl of 2-7 carbon atoms, aminocarbonyl, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, acyl of 2-7 carbon atoms, acylamino of 2-7 carbon atoms, amino, phenylalkyl having 1-6 carbon atoms in the alkyl moiety, or â€”NR5SO2R5; R2 is hydrogen, or alkyl of 1-6 carbon atoms; R3 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or halogen; R4 is (a) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, S, and N, optionally substituted with R6; (b) a phenyl ring optionally substituted with R6; (c) phenylalkyl having 1-6 carbon atoms in the alkyl moiety; or (d) alkyl of 1-6 carbon atoms; R5 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl; R6 is alkyl of 1-6 carbon atoms, halogen, trifluoromethyl, trifluoromethoxy, alkoxy of 1-6 carbon atoms, hydroxy, nitro, amino, cyano, aminocarbonyl, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, acyl of 2-7 carbon atoms, acylamino of 2-7 carbon atoms, amino, phenylalkyl having 1-6 carbon atoms in the alkyl moiety, â€”CO2R5, or â€”NR5SO2R5; or is a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, S, and N mono- or di- substituted with R2; is (a) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S; or (b) a phenyl ring; is (a) a phenyl ring; or (b) a phenyl fused to a 5-membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S; Y is alkyl of 1-6 carbon atoms; Z is a bond, or â€”OCH2â€”; m is 1-2; with the proviso that are both not phenyl;or a pharmaceutically acceptable salt thereof.