Patent ID: 8420112
Filing Date: 2013-04-16
Classification: A61K,A61P

Abstract:
1. A retrievable solid, long-acting dosage form for implantation in a palatine canal of a patient for releasing a local anesthetic near sphenopalatine ganglion (SPG) for a period of between 1 and 6 months, whereby anesthetizing a dorsonasal nerve structure and inhibiting a cerebral neurovascular disorder in the patient, comprising: i) a carrier member comprising an elongate structural support having a length of from about 5 mm to 15 mm, and a pharmaceutically acceptable polymer film having a width of between 50 and 5000 nm and comprising a plurality of perforations, forming the external surface of said carrier member through which said anesthetic diffuses to said canal of the patient, the support comprising a distal end and a proximal end; ii) a local anesthetic mixed with PLGA contained in said carrier member; and iii) a retrieval member located near said proximal end, and connected to said carrier member; wherein the diffusion of said anesthetic through said film near said distal end is at least 10 times greater than near said proximal end.