Patent ID: 8926972
Filing Date: 2015-01-06
Classification: A61K,A61P,C07K

Abstract:
1. A fusion protein comprising a chimeric VEGF receptor or a fragment thereof and a multimerizing component, wherein the chimeric VEGF receptor or the fragment thereof comprises at least two immunoglobulin-like domains from different VEGF receptors, one being the immunoglobulin-like domain 2 of the extracellular domain of KDR (KDRD2) as set forth in amino acids 12-95 of SEQ ID NO:2, another being the immunoglobulin-like domain 2 of the extracellular domain of F1t1 (F1t1D2) as set forth in amino acids 21-96 of SEQ ID NO:1, and the fusion protein binds with high affinity to VEGF.