Patent ID: 6326350
Filing Date: 2001-12-04
Classification: A61P,C07K

Abstract:
A composition of matter comprising a recombinant protein and a carrier therefor, wherein said protein comprises an amino acid sequence selected from the group consisting of:the sequence of the Tbp2 subunit of N. meningitidis strain IM2394 as shown in SEQ ID NO:2, starting with the cysteine residue in position 1 and ending with the glutamine residue in position 579; andthe sequence of the Tbp2 subunit of N. meningitidis strain IM2169 as shown in SEQ ID NO:8, starting with the cysteine residue in position 1 and ending wiht the glutamine residue in position 691;further wherein said protein is recognized by an antiserum against a transferrin receptor comprising the Tbp1 and Tbp2 subunits of the naturally-occurring transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis, wherein said protein is obtained by culturing a host cell transformed by an expression cassette comprising a DNA molecule encoding said protein and placecd under control of appropriate elements for expression in E. coli, under conditions that allow expression of said protein, and recovering said protein from the culture.