Patent ID: 8993565
Filing Date: 2015-03-31
Classification: A61P,C07D

Abstract:
1. A method of treating cancer capable of being modulated by inhibition of AKT phosphorylation in a patient in need thereof comprising administering to said patient an effective dose of a compound according to formula (I): in which: R1 represents an aryl or heteroaryl radical optionally substituted with one or more substituents, which may be identical or different, chosen from halogen, hydroxyl, CN, nitro, —COOH, —COOalkyl, —NRxRy, —CONRxRy, —NRxCORy, —CORy, —NRxCO R represents a hydrogen atom or, together with R1, forms a saturated or partially or totally unsaturated 5- or 6-membered ring fused to an aryl or heteroaryl residue to form a bicyclic radical, said bicyclic radical optionally containing one or more heteroatoms chosen from O, S, N, NH and N(alkyl); R2 and R3, which may be identical or different, independently represent a hydrogen atom, a halogen atom or an alkyl radical optionally substituted with one or more halogen atoms; R4 represents a hydrogen atom; R5 represents a hydrogen atom or an alkyl radical optionally substituted with one or more halogen atoms; NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom, a cycloalkyl radical or an alkyl radical, wherein each of said cycloalkyl radical and said alkyl radical may optionally be substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NRvRw and heterocycloalkyl; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this radical being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and alkyl, hydroxyl oxo, alkoxy, NH NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or a cycloalkyl radical, CO Rz represents a cycloalkyl radical or an alkyl radical, wherein each of said cycloalkyl radical and said alkyl radical may optionally be substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NRvRw and heterocycloalkyl; and each of said alkyl, alkoxy and alkylthio radicals being linear or branched and containing from 1 to 6 carbon atoms; or a pharmaceutical acceptable salt thereof.