Patent ID: 8685416
Filing Date: 2014-04-01
Classification: A61K,A61P

Abstract:
1. A method of inducing an immune response to a tumor in a subject, comprising, selecting a subject with a tumor; and administering a therapeutically effective amount of apoptotic tumor cells conjugated to a CpG oligodexoynucleotide to the subject, wherein the CpG oligodeoxynucleotide is a K-type CpG oligodeoxynucleotide or a D-type CpG oligodeoxynucleotide wherein the K-type CpG oligodeoxynucleotide has a nucleic acid sequence set forth as: wherein the central CpG motif is unmethylated, D is T, G or A, W is A or T, and N wherein the D-type CpG oligodeoxynucleotide has a sequence wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10, wherein the CpG ODN is 18 to 50 nucleotides in length; thereby inducing the immune response to the tumor in the subject.