Patent ID: 7244834
Filing Date: 2007-07-17
Classification: A61K,C07K

Abstract:
1. An isolated nucleic acid encoding a polypeptide of the structure or formula S-(L) n -B wherein: (a) S is selected from the group consisting of PTH(1–9) (AlaValSerGluIleGlnLeuMetHis) (SEQ ID NO: 1), PTH(1–5) (AlaValSerGluIle) (SEQ ID NO: 4) or PTH (1–11) (AlaValSerGluIleGlnLeuMetHisAsnLeu) (SEQ ID NO: 46); (b) L is a glycine present n times; (c) n is 5 to 10; and (d) B is a carboxy terminal binding domain of PTH(1–34) or PTHrP(1–34), wherein said carboxy terminal binding domain binds to a PTH-receptor 1 molecule wherein said polypeptide stimulates intracellular accumulation of cyclic cAMP.