Patent ID: 8569497
Filing Date: 2013-10-29
Classification: C07D

Abstract:
1. A process for the preparation of a compound of general formula (I) wherein R C C monocyclic, bicyclic or tricyclic aryl group optionally substituted with one or more C a monocyclic, bicyclic or tricyclic cycloalkyl group, or R 1 and R 2 together with the adjacent nitrogen atom may form a saturated or unsaturated, monocyclic or bicyclic heterocyclic ring which may contain further heteroatoms selected from oxygen, nitrogen or sulphur atoms comprising reacting the compound of formula (III) with a carbamoylchloride of general formula (II) wherein R 1 and R 2 are as described above which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100° C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.