Patent ID: 7261894
Filing Date: 2007-08-28
Classification: A61K,C07K

Abstract:
1. A method of treating an individual afflicted with an inflammatory and/or autoimmune disease selected from the group consisting of asthma, inflammatory bowel disease, psoriasis, and combinations thereof, comprising administering to the individual an antagonistic antibody immunoreactive with IL-1 epsilon comprising the amino acid sequence set forth in SEQ ID NO:8 or 13, wherein the antibody decreases induction of a biological activity of the IL-1 epsilon selected from the group consisting of: expression of one or more cytokines selected from the group consisting of IL-1 alpha, IL-1 beta, TNF-alpha, IL-10, IFN-gamma, IL-12 p40, IL-6; expression of one or more cell-surface molecules selected from the group consisting of ICAM-1, TLR4, TLR5, TLR9, DC-B7; and activation of one or more signaling molecules selected from the group consisting of NFkappaB, p38 MAP kinase, Stress-Activated Protein Kinase (SAPK/JNK).