Patent ID: 6160112
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A method for preparing a 1,1-dioxopenicillanic acid compound corresponding to formula I: ##STR4## wherein R represents hydrogen, an alkyl group containing 1 to 5 carbon atoms or a group corresponding to the formula:CH.sub.2 R'wherein R' represents hydrogen, halogen or p-toluensulfonyl; said method comprising:treating a compound corresponding to formula II: ##STR5## wherein R is as defined above and X is hydrogen or bromine with a metallic dehalogenating reagent consisting of a mixture or alloy of at least one metal selected from the group consisting of copper, cobalt and manganese, with at least one metal selected from the group consisting of iron and nickel in an aqueous organic medium.