Patent ID: 6413951
Filing Date: 2002-07-02
Classification: C07J

Abstract:
A compound, or a pharmaceutically acceptable salt thereof of the formula: wherein:R1 is H or C1-4 alkyl; R2 is H or C1-4 alkyl; R3 is H, chloro, nitro, amino or C1-4 alkyl; R4 is H or C1-4 alkyl; R5 is H or C1-4 alkyl; R6 is H or methyl; R7 is H or methyl; R8 is H or methyl; R9 is H or methyl; or R8 and R9 taken together is oxo; R10 is H or methyl; R11 is H; R12 is hydroxy; or R11 and R12 taken together is oxo; X is H, hydroxy or methoxy; with the proviso that when: a) R11 is H and R12 is hydroxy, bond C4,5 is a single bond, bond C5,6 is a double bond and bond C15,16 is optionally a single bond or a double bond, and b) R11 and R12 taken together is oxo, bond C4,5 is a double bond, bond C5,6 is a single bond, bond C15,16 is a single bond, and R8 and R9 are each methyl or R8 and R9 taken together is oxo.