Patent ID: 6576656
Filing Date: 2003-06-10
Classification: A61P,C07D

Abstract:
An oxindole compound of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof: whereinR1 and R3 are the same or different and each is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, halogen, cyano, nitro, hydroxy, optionally substituted amino, alkoxy, alkanoyl, alkoxycarbonyl, optionally substituted sulfamoyl, optionally substituted carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonylamino or alkanoylamino; R2 and R4 are hydrogen; provided that all of R1, R2, R3 and R4 are not simultaneously hydrogen; R5 is optionally substituted aryl; â€”Z â€”Oâ€” is or â€”NHâ€”; W1 is hydrogen; W2 is â€ƒn is 1, 2 or 3; m is 0, 1, 2 or 3; R6 and R7 are the same or different and each is independently optionally substituted alkyl or optionally substituted cycloalkyl; and R8 and R9 are the same or different and each is independently hydrogen or optionally substituted alkyl; or R8 and R9 are taken together with the adjacent carbon atom to form optionally substituted cycloalkane.