Patent ID: 8957460
Filing Date: 2015-02-17
Classification: G01N

Abstract:
1. A semiconductor device for the detection of an active site-containing protein or a ligand thereof in a solution, said device being composed of at least one insulating or semi-insulating layer, at least one conducting semiconductor layer, two conducting pads, a protective molecular layer, and said ligand or active site-containing protein, wherein said at least one conducting semiconductor layer is on top of one of said insulating or semi-insulating layers, said two conducting pads are on both sides on top of an upper layer which is either one of said conducting semiconductor layers or another of said insulating or semi-insulating layers, making electrical contact with said at least one conducting semiconductor layer, said protective molecular layer is fabricated on top of said upper layer protecting said upper layer from corrosion, and said ligand or active site-containing protein is linked either directly or indirectly to said protective molecular layer, wherein exposure of said ligand or active site-containing protein, to a solution containing said active site-containing protein or ligand, respectively, causes a current change through the semiconductor device when a constant electric potential is applied between the two conducting pads.