Patent ID: 8097734
Filing Date: 2012-01-17
Classification: A61P,C07D

Abstract:
1. A method for the preparation of crystalline sodium atorvastatin, the method comprising: (a) adding amorphous sodium atorvastatin to a first organic solvent to form a first solution; (b) adding a second organic solvent to the first solution to form a second solution; (c) allowing sodium atorvastatin to crystallize out from the solution; and (d) collecting the crystallized sodium atorvastatin, wherein the first organic solvent is ethanol and the second organic solvent is acetone, thereby obtaining crystalline sodium atorvastatin which exhibits an X-ray powder diffraction pattern comprising peaks expressed in degrees two-theta at approximately 3.36±0.2, 4.8±0.2, 5.59±0.2, 7.41±0.2, 8.3±0.2, 8.81±0.2, 9.69±0.2, 10.24±0.2, 11.13±0.2, 11.21±0.2, 12.22±0.2, 12.8±0.2, 13.85±0.2, 15.99±0.2, 16.40±0.2, 16.95±0.2, 17.82±0.2, 18.15±0.2, 18.46±0.2, 19.48±0.2, 20.86±0.2, 21.82±0.2, 22.88±0.2, 23.98±0.2, 28.34±0.2, 32.27±0.2, and 33.40±0.2.