Patent ID: 7264809
Filing Date: 2007-09-04
Classification: C07K

Abstract:
1. A method for inhibiting platelet activation and recruitment in a mammal in need of such treatment comprising administering an effective amount of a soluble CD39 polypeptide consisting of a structure X-Y wherein X is an Ala residue or heterologous peptides selected from the group consisting of amino acids 25-39 of SEQ ID NO:11, amino acids 25-35 of SEQ ID NO:28, amino acids 27-34 of SEQ ID NO:29, and amino acids 21-24 of SEQ ID NO:30 and Y is selected from the group consisting of: (a) a polypeptide consisting of amino acids 36-478 of SEQ ID NO:2; (b) a fragment of the polypeptide of (a) consisting of consecutive amino acids of (a) wherein said fragment has apyrase activity; (c) a variant polypeptide that is at least 95% identical in amino acid sequence to (a) or (b) wherein said variant polypeptide has apyrase activity; and (d) a substituted polypeptide consisting of the amino acids of (a), (b), or (c) with at least one conservative amino acid substitution wherein said substituted polypeptide has apyrase activity.