Patent ID: 6797720
Filing Date: 2004-09-28
Classification: A61K,C07D,C07K

Abstract:
A compound of formula (Id) or (Ia)â€² wherein W is oxygen or sulfur, R is (i) hydrogen, (ii) C1-8 alkyl, (iii) CycA, (iv) C1-8 alkyl substituted with a group selected from halogen, CycA, nitro, CF3 and cyano, CycA is a mono-, bi- or tri-cyclic C3-15 carboning R16 is (1) C1-8 alkyl, (2) C2-8 alkenyl, (3) C2-8 alkynyl, (4) CycA or (5) C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl substituted with a group selected from halogen, nitro, CF3, cyano, CycA, NR18R19 and â€”NHC(O)â€”CycA; R17 is hydrogen or C1-4 alkyl, R18 and R19 are the same or different and represent hydrogen or C1-4 alkyl; R48 is hydrogen, C1-4 alkyl, phenyl or C1-4 alkyl substituted with phenyl; CycD is a C3-C14 mono- or bi-cyclic carboring R7 and R8 are the same or different and represent (i) hydrogen, (ii) C1-8 alkyl, (iii) CycA or (iv) C1-8 alkyl substituted with 1-5 of a group selected from the following (1) to (8): (1) â€”NR61R62, (2) â€”OR63, (3) â€”SR64, (4) â€”COR65, (5) â€”NR66CONR61R62, (6) guanidino, (7) CycA, or (8) â€”NR66SO2R61, or R7 and R8 are taken together to form C2-8 alkylene, wherein one carbon atom may be replaced by oxygen, sulfur or â€”NR60 and the alkylene may be substituted with â€”NR61R62 or â€”OR63, R60 is hydrogen, C1-4 alkyl, â€”COOâ€”(C1-4 alkyl), phenyl or C1-4 alkyl substituted with phenyl, R61, R62, R63, R64 and R66 are the same or different and represent hydrogen, C1-4 alkyl, phenyl or C1-4 alkyl substituted with phenyl, R65 is C1-4 alkyl, phenyl, â€”NR61R62, wherein all symbols have the same meanings as above, â€”OR63, wherein R63 has the same meaning as above, or C1-4 alkyl substituted with phenyl; R9 is hydrogen, C1-8 alkyl, phenyl or C1-8 alkyl substituted with phenyl or R9 is taken together with R7 to form C2-6 alkylene, wherein one carbon atom may be replaced by oxygen, sulfur or â€”NR60â€” and the alkylene may be substituted with â€”NR61R62 or â€”OR63; and when CycA is included in any or all of R, R7, and R8, they may be the same or different and CycA, and CycD, independently, may be substituted with 1-5 of R27; R27 is (1) C1-8 alkyl, (2) halogen, (3) â€”NR11R12, (4) â€”OR13, (5) a C5-10 mono-or bi-cyclic carboring, (6) nitro, (7) CF3, (8) cyano, (10) â€”COR15, (11) oxo, (12) â€”SO2R15, (13) â€”OCF3 or (14) C1-8 alkyl substituted with 1-5 of a group selected from the following (a) to (k): (a) halogen, (b) â€”NR11R12, (c) â€”OR13, (d) a C5-10 mono- or bi-cyclic carboring, (e) nitro, (f) CF3, (g) cyano, (h) â€”SR14, (i) â€”COR15, (j) â€”SO2R15, and (k) â€”OCF3, wherein R11 and R12 are the same or different and represent hydrogen, C1-4 alkyl, â€”COOâ€”(C1-4 alkyl), phenyl or C1-4 alkyl substituted with phenyl, R13 and R14 are the same or different and represent hydrogen, C1-4 alkyl, phenyl or C1-4 alkyl substituted with phenyl, R15 is C1-4 alkyl, phenyl, â€”NR11R12, wherein all symbols have the same meanings as above, â€”OR13, wherein R13 has the same meaning as above, or C1-4 alkyl substituted with phenyl, or a non-toxic salt thereof.