Patent ID: 8642727
Filing Date: 2014-02-04
Classification: A61K,A61P,C07K

Abstract:
1. A glucagon-like peptide 2 (GLP-2) analogue represented by the general Formula I: wherein: R X2 is Gly, Ala or Sar; X3 is Glu or Asp; X5 is Ser or Thr; X6 is Phe or Pro or a conservative substitution; X7 is Ser or Thr; X8 is Asp or Ser or a conservative substitution; X9 is Glu or Asp or a conservative substitution; X10 is Met, Leu, Nle or an oxidatively stable Met-replacement amino acid; X11 is Y1; X12 is Thr or Lys or a conservative substitution; X13 is Ile, Glu or Gln or a conservative substitutio; X14 is Leu, Met or Nle or a conservative substitution; X15 is Asp or Glu; X16 is Y2; X17 is Leu or Glu or a conservative substitution; X18 is Ala or Aib or a non-conservative substitution; X19 is Ala or Thr or a conservative substitution; X20 is Y3 X21 is Asp or Ile or a conservative substitution; X24 is Y4; X28 is Y5; X31 is Pro, Ile or deleted; X32 is Thr or deleted; X33 is Asp, Asn or deleted; R wherein Z the hydrophaticity profile (HPP) of the residues X11, X16, X20, X24, X28 of formula I calculated as wherein Y Y with the proviso that when X20 is Arg then X11 is Ser, X16 is Ala, X24 is Ala, X28 is Ala and Z2 is Lys, or a pharmaceutically acceptable salt thereof and with the proviso that if X15 is Asp then X8 is Ser.