Patent ID: 9085600
Filing Date: 2015-07-21
Classification: A61P,C07H

Abstract:
1. A compound having the structure: or a pharmaceutically acceptable salt, ester, or N-oxide thereof, wherein T is: wherein: M is selected from: R R R R alternatively, R alternatively, R alternatively, R R K is selected from: alternatively, R wherein R alternatively, R wherein V is selected from(a) —(C R alternatively, R alternatively, R alternatively, R wherein in the preceding structure the dotted line indicates an optional double bond, alternatively, R R alternatively, R alternatively, R alternatively, M, R wherein in the preceding structure the dotted line indicates an optional double bond, wherein J 1 and J 2 are selected from hydrogen, Cl, F, Br, I, OH, -C 1-6 alkyl, and —O(C 1-6 alkyl) or taken together form ═O, ═S and ═NR 114 , ═NOR 114 , ═NR 114 ,or ═N—NR 114 R 114 ; alternatively, M and R wherein U is selected from (a) —(C alternatively, M and R R alternatively, R R R R alternatively, NR R R alternatively, NR alternatively, CR R alternatively, two R R R R R alternatively, two R R R R R R alternatively, R alternatively, R R alternatively, R alternatively, R alternatively, R alternatively, when M is a carbon moiety, R k, at each occurrence is 0, 1, or 2; m, at each occurrence is 0, 1, 2, 3, 4, or 5; n, at each occurrence is 1, 2, or 3; p, at each occurrence is 0, 1, or 2; r, at each occurrence is 0, 1, or 2; t, at each occurrence is 0, 1, or 2; u at each occurrence is 1, 2, 3, or 4; R R A is a C G is selected from: (a) —B′ and (b) —B′—Z—B″, wherein R alternatively, NR R R alternatively, NR alternatively, CR R alternatively, two R R R R R R