Patent ID: 8975081
Filing Date: 2015-03-10
Classification: C12Q,G01N

Abstract:
1. A method of determining a course of treatment of an inflammatory disease in a patient undergoing treatment of the inflammatory disease with an active agent that influences CD73 protein level or activity in the patient, the method comprising: (a) identifying a patient undergoing treatment of an inflammatory disease with an agent that influences the CD73 protein level or activity in the patient, wherein the inflammatory disease is selected from the group consisting of acute lung injury, acute respiratory distress syndrome, acute pancreatitis, multi-organ failure and systemic inflammatory response syndrome; (b) obtaining a sample of tissue fluid from the patient at a first or earlier point in time; (c) determining the amount of CD73 protein or the activity of the CD73 protein in the sample at the first or earlier point in time; (d) obtaining a sample of tissue fluid from the patient at a second or subsequent point in time; (e) determining the amount of CD73 protein or the activity of the CD73 protein in the sample at the second or subsequent point in time; (f) comparing the amount of the CD73 protein or the activity of the CD73 protein in the sample at the second or subsequent point in time with that of the first or earlier point in time; (g) determining the course of treatment of the patient with an agent that influences the CD73 protein level or activity in the patient from the comparison of the amount of the CD73 protein or the activity of the CD73 protein in the sample by (h) repeating steps (d)-(f); and (i) determining the course of treatment of the patient with an agent that influences the CD73 protein level or activity in the patient from the comparison of the amount of the CD73 protein or the activity of the CD73 protein in the sample by