Patent ID: 7645573
Filing Date: 2010-01-12
Classification: C12Q,G01N

Abstract:
1. A method of predicting an increased likelihood of developing sepsis in a human SIRS patient comprising: determining abundances of Fc fragment of IgG, high affinity 1A receptor (FCGR1A) mRNA and extra-hepatic arginase (ARG2) mRNA in a first blood sample taken from the human SIRS patient; and comparing the abundances of FCGR1A and ARG2 mRNAs in the first blood sample to abundances of FCGR1A and ARG2 mRNAs in blood samples taken 0-48 hours prior to sepsis in a SIRS-positive human patient population that progresses to sepsis, wherein the abundances of FCGR1A and ARG2 mRNAs in the blood samples taken from the SIRS-positive human patient population that progresses to sepsis are statistically significantly greater than abundances of FCGR1A and ARG2 mRNAs in blood samples taken from a SIRS-positive human patient population that does not progress to sepsis, and wherein an increased likelihood of developing sepsis is predicted in the SIRS patient when it is determined that the FCGR1A and ARG2 mRNA abundances in the first blood sample are statistically significantly similar to the abundances of FCGR1A and ARG2 mRNAs in the blood samples taken from the SIRS-positive human patient population that progresses to sepsis, and wherein the SIRS-positive patient population that progresses to sepsis and the SIRS-positive human patient population that does not progress to sepsis each comprise at least 20 individuals.