Patent ID: 6225331
Filing Date: 2001-05-01
Classification: A61P,C07D

Abstract:
A compound of formula; ##STR13##wherein;a) R.sub.1 is hydrogen; or alkyl or nil; where R.sub.1 is nil, bond (.alpha.) is a double bond;b) D is CR.sub.2 and R.sub.2 is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl; amino, hydroxy, mercapto; C.sub.1 -C.sub.3 alkylthio or alkoxy; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino and halo; or when B is CR.sub.3 ; D may be N;c) B is NR.sub.9, CR.sub.3, S, O, SO or SO.sub.2 ; wherein R.sub.9 is selected from hydrogen; and unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; and wherein R.sub.3 and R.sub.8 are each independently selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino and halo;d) R.sub.4, R.sub.5 and R.sub.6 are each independently selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino; halo; and NH--C(.dbd.NR.sub.10)NHR.sub.11 (guanidinyl); wherein R.sub.10 and R.sub.11 are independently selected from hydrogen; methyl; and ethyl; and wherein one and only one of R.sub.4, R.sub.5 and R.sub.6 is guanidinyl;e) R.sub.7 is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino and halo;or its enantiomer, optical isomer, stereoisomer, diastereomer, tautomer, addition salt, or biohydrolyzable amide or ester.