Patent ID: 9144551
Filing Date: 2015-09-29
Classification: A61K,A61P

Abstract:
1. A pharmaceutical formulation having a decreased abuse potential comprising particles, wherein each particle comprises: (a) drug-free granules, beads or mini-tablets comprising at least one bittering agent selected from the group consisting of sugar octaacetate, denatonium benzoate, denatonium saccharide, caffeine, quinine or a quinine salt, bitter orange peel oil, pepper extract and capsicum; (b) a first pharmaceutically acceptable coating atop the drug-free granules, beads or mini-tablets that does not dissolve in a gastro-intestinal tract, such that the bittering agent is not released in a human body when the formulation is properly administered; (c) a second pharmaceutically acceptable coating atop the first coating consisting essentially of an active pharmaceutical ingredient (API) selected from the group consisting of opioids, central nerve system (CNS) depressants and stimulants; and (d) a third pharmaceutically acceptable coating atop the second coating, the third coating comprising an enteric coating, a sustained release coating, or both.