Patent ID: 6013649
Filing Date: 2000-01-11
Classification: A61K,A61P,C07C

Abstract:
A matrix metalloprolease inhibitor compound corresponding to the formula: ##STR1175## wherein R.sup.1 is a substituted aryl or heteroaryl radical having a length greater than about that of a pentyl group and a length that is less than that of a stearyl group, and when rotated about an axis drawn through the SO.sub.2 -bonded 1-position and the 4-position of a 6-membered ring or the SO.sub.2 -bonded position and substituent-bonded 3- or 5-position of a 5-membered ring defines a three-dimensional volume whose widest dimension has the width of about one phenyl ring to about three phenyl rings in a direction transverse to that axis to rotation;R.sup.2 and R.sup.3 are radicals independently selected from the group consisting of hydrido, C.sub.1 -C.sub.6 alkyl, single-ringed aralkyl or heteroaralkyl having 1-3 carbons in the alkyl chain, cycloalkylalkyl having 4-8 carbons in the ring and 1-3 carbons in the alkyl chain, and heterocycloalkylalkyl in which 4-8 atoms are in the ring, one or two of which atoms are nitrogen, oxygen or sulfur and in which the alkyl chain contains 1-3 carbons, or wherein R.sup.2 and R.sup.6 together with the atoms to which they are bonded form a 5- or 6-membered ring;R.sup.6 is a radical selected from the group consisting of an C.sub.1 -C.sub.6 alkyl group, a carboxyl group, a C.sub.1 -C.sub.6 alkoxy carbonyl group, an amino C.sub.1 -C.sub.6 alkanoyl group, a carboxamide group where the amido nitrogen is (i) unsubstituted or substituted with (ii) a C.sub.1 -C.sub.4 alkyl substituted by amino, mono-substituted amino or di-substituted amino, wherein the substituent on the amino nitrogen is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.8 cycloalkyl and C.sub.1 -C.sub.6 alkanoyl groups, or wherein two amino nitrogen substitutents and the nitrogen to which they are bonded together form a 5- to 8-membered heterocyclic or heteroaryl ring containing zero or one additional hetero atoms that are nitrogen, oxygen or sulfur or (iii) the amido nitrogen is the amine of an amino acid;W is oxygen (O) or sulfur (S); andR.sup.10 is aryl or heteroaryl having a single ring or C.sub.1 -C.sub.6 alkoxy.