Patent ID: 6403817
Filing Date: 2002-06-11
Classification: C07C

Abstract:
A method for preparing a prostaglandin E-type compound of the formula (I), whereinA is X is trans â€”CH&boxH;CHâ€” or â€”CH2â€”CH2â€”; Y and Z each independently is trans â€”CH&boxH;CHâ€”, cisâ€”CH&boxH;CHâ€” or â€”CH2â€”CH2â€”; and a pharmaceutically acceptable salt thereof, which comprising: reacting a compound of the formula (II) whereinX, Y and Z are defined as above; R is H or â€”Si(C2H5)3; B is with a Cr(VI)-based reagent or activated dimethyl sulfoxide in a halogen-containing solvent to proceed an oxidation reaction, and then reacting with an acidic aqueous solution having pH=4Ëœ6 in the presence of a water-soluble low-boiling-point organic solvent to proceed a desilylation reaction.