Patent ID: 6379651
Filing Date: 2002-04-30
Classification: A61K,A61Q,Y10S

Abstract:
In a method of treating Helicobacter Pylori infection by administering and ingesting peroral tablets of an antibiotic/antibacterial compound with a Bismuth compound, the improvement comprising concornitantly administering and chewing within an oral cavity an antibiotic/antibacterial compound with a Bismuth compound in a topical chewing gum dosage form which releases the antibiotic/antibacterial into the oral cavity in a concentration sufficient to reduce or eliminate the Helicobacter Pylori in the oral cavity, said Bismuth compound being selected from the group consisting of colloidal bismuth subcitrate, bismuth subcitrate, bismuth citrate, bismuth salicylate, bismuth subsalicylate, bismuth subnitrate, bismuth subcarbonate, bismuth tartrate, bismuth subgallate, tripotassium dicitrato bismuthate, bismuth aluminate, bismuth polysulfate complexes, bismuth polyhydroxy complexes, alpha-D-glucopyranoside bismuth complex, beta-D-fructofuranosyl-oktakis (hydrogen sulfate) bismuth complex, and L-dihydro ascorbyl-tetrakis (hydrogen sulfate) bismuth complex, said antibiotic/antibacterial compound being selected from the group consisting of Nicin peptides, Nicin-related peptides, Tetracycline, Amoxycillin, Ampicillin, Doxycycline, Erythromycin, Clarithromycin, Metronidazole, Tinidazole, Ciproflaxacin, Oflaxacin, Norflaxacin, Furazolidine, and Nitrofurantoin.