Patent ID: 7119209
Filing Date: 2006-10-10
Classification: C07D

Abstract:
1. A process for preparing an indolinone of the general formula (VI) wherein R each R R R R R R R R′ and R″ are independently selected from the group consisting of hydrogen, C Halo is a substituent selected from the group consisting of F, Cl, Br, and I J is selected from the group consisting of O, S, and NH; one of K, L and M is C and the group —C(O)R n is 0, 1 or 2; m is 1, 2, 3, or 4; and p is 0, 1 or 2; comprising the steps of (i) reacting a compound of general formula (I) wherein R Q is selected from the group consisting of with a compound of general formula (II) wherein: (a) one of X (b) X or (c) X X and R is to form a compound of the general formula (III) wherein R* is —O—R in case (a) of step (i) and —R in cases (b) and (c) of step (i); (ii) reacting the compound of general formula (III) with a compound of general formula (IV) wherein R and an amine of general formula (V) wherein R