Patent ID: 6720428
Filing Date: 2004-04-13
Classification: A61P,C07D

Abstract:
A process for preparing a 2-(1,2,4-triazol-1-yl)-ethanol of the formula (I) whereinA1 and A2 independently of one another represent a direct bond, represent optionally halogen-substituted alkanediyl, represent optionally halogen-substituted alkenediyl, represented optionally halogen-substituted alkinediyl or represent alkanediyl in which a methylene group is replaced by oxygen, R1 and R2 independently of one another represent hydrogen, represent optionally substituted cycloalkyl or represent optionally substituted aryl and R3 and R4 independently of one another represent hydrogen or represent optionally substituted alkyl or R3 and R4 together with the carbon atom to which they are attached represent optionally substituted cycloalkyl, or R1, A1 and R3 together with the carbon atoms to which they are attached represent cycloalkyl, A2 represents a direct bond, represents optionally halogen-substituted alkanediyl, represents optionally halogen-substituted alkenediyl, represents optionally halogen-substituted alkinediyl or represents alkanediyl in which one methylene group has been replaced by oxygen, R2 represents hydrogen, represents optionally substituted cycloalkyl or represents optionally substituted aryl and R4 represents hydrogen or represents optionally substituted alkyl, or R3 and R4 represent hydrogen and the groups R1â€”A1â€” and R2â€”A2â€” together with the carbon atom to which they are attached represent a radical of the formula said process comprising the step of reacting a hydrazine derivative of the formula (II) whereinA1, A2, R1, R2, R3 and R4 are as defined above with an N-dihalogenomethyl-formamidinium halide of the formula (III) whereinX represents chlorine or bromine, optionally in the presence of a diluent.