Patent ID: 6858591
Filing Date: 2005-02-22
Classification: A61K,C07H,C07K,C12N,C12P,C12R,Y10S

Abstract:
1. A compound of the formula wherein: m is an integer of 0 to 2; n is an integer of 0 to 13; p is an integer of 0 to 2; q is an integer of 0 to 5; J is F, Cl or Br; R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of -J, —R cycloalkyl of 3 to 10 carbon atoms optionally substituted with one to three alkyl groups of 1 to 6 carbon atoms; silyl substituted with three groups independently selected from R —C(O)R allyl optionally substituted with one to three moieties independently selected from R R aryl; R R R aryl may optionally be substituted by —V-aryl, —V—R V is selected from C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHSO R R R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of -J, —R cycloalkyl of 3 to 10 carbon atoms optionally substituted with one to three alkyl groups of 1 to 6 carbon atoms; —C(O)R —C(O)OR allyl optionally substituted with one to three groups independently selected from R R aryl; R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of —R allyl optionally substituted with one to three groups independently selected from R aryl; cycloalkyl group of 3 to 10 carbon atoms, which may be optionally substituted with one or more alkyl groups of 1 to 6 carbon atoms; R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of -J, —R —C(O)(CR cycloalkyl of 3 to 10 carbon atoms optionally substituted with one to three alkyl groups of 1 to 6 carbon atoms; —C(O)R allyl optionally substituted with one to three groups independently selected from R R aryl; R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of —R allyl optionally substituted with one to three groups independently selected from R aryl; cycloalkyl group of 3 to 10 carbon atoms, which may be optionally substituted with one or more alkyl groups of 1 to 6 carbon atoms; R H; alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 3 substituents selected from the group consisting of -J, —R silyl substituted with three groups independently selected from R cycloalkyl of 3 to 10 carbon atoms optionally substituted with one to three alkyl groups of 1 to 6 carbon atoms; —C(O)R allyl optionally substituted with one to three groups independently selected from R R aryl; R H; F; an alkyl group of 1 to 10 carbon atoms including their branches; allyl optionally substituted with one to three groups independently selected from R aryl; or a pharmaceutically acceptable salt thereof.