Patent ID: 6306432
Filing Date: 2001-10-23
Classification: A61K,A61P

Abstract:
A multivesicular liposome having multiple non-concentric chambers with membranes distributed as a continuous network throughout, made by a process comprising the steps of:a. forming a first aqueous component comprising insulin-like growth factor I (IGF-I) in a concentration range from about 40 mg/mL to about 300 mg/mL, an osmotic excipient and a pH adjusting agent, wherein the aqueous component is calibrated to have an osmolarity in the range from about 5 mOsm and to have a pH in the range from about 2 to about 4.8;b. forming a lipid component comprising at least one organic solvent, at least one amphipathic lipid, and a neutral lipid lacking a hydrophilic headgroup;c. forming an emulsion from the first aqueous component and the lipid component;d. dispersing the emulsion into a second aqueous component to form solvent spherules; ande. removing the organic solvent from the solvent spherules to form multivesicular liposomes suspended in the second aqueous component.