Patent ID: 8288403
Filing Date: 2012-10-16
Classification: A61P,C07D

Abstract:
1. A method of treating a disorder selected from the group consisting of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome, comprising administering a therapeutically effective amount of a compound of formula I wherein R R′ is lower alkyl; R Z is N, C, O or S; V is N, C(R″), O or S; W is N, C(R″), O, or S; Y is N or C; with the proviso that only one of Z, V or W is O or S; R″ is hydrogen, lower alkyl, lower alkyl substituted by halogen or hydroxy, or C(O)O—R L is a bond, —(CR each R R R′″ is halogen, cyano, lower alkyl, lower alkyl substituted by halogen or hydroxy, lower alkoxy or C(O)O—R n is 1, 2 or 3; or a pharmaceutically active acid addition salt thereof.