Patent ID: 6174908
Filing Date: 2001-01-16
Classification: A61K,C07D

Abstract:
A method for treating a disease, condition, or disorder which responds to the inhibition of potassium channel function by administering to a patient in need thereof, a pharmaceutically effective amount of a compound having the following formula, or a pharmaceutically acceptable salt, ester, amide, complex, chelate, hydrate, stereoisomer, crystalline or amorphous form, metabolite, metabolic precursor or prodrug thereof: ##STR25##wherein,v is 0 or 1;t is 0, 1, or 2;X, in an orientation R.sup.1 --X--, is selected from --(CR.sup.4.sub.2).sub.p --; --(CR.sup.4.sub.2).sub.m O(CR.sup.4.sub.2).sub.m CH.dbd.CH(CR.sup.4.sub.2).sub.s --; --(CR.sup.4.sub.2).sub.m CH.tbd.CH(CR.sup.4.sub.2).sub.s --; --(CR.sup.4.sub.2).sub.m --A--(CR.sup.4.sub.2).sub.m --; ##STR26##--(CR.sup.4.sub.2).sub.m --NR.sup.4 --(CR.sup.4.sub.2).sub.n --; ##STR27##and ##STR28##where p is an integer of 0 to 5, n is an integer of 2 to 4, m is an integer of 0 to 4 and s is an integer of 1 to 4; A is selected from an optionally substituted 3 to 7 membered carbocyclic ring and an optionally substituted 5 to 7 membered heterocyclic ring; each R.sup.4 is independently selected from H, a lower alkyl, an aryl and a heteroaryl; W is selected from 0 and NR.sup.5 where R.sup.5 is selected from H lower alkyl, aryl, C.tbd.N and NHR.sup.4 ;R.sup.1 is selected from H, an optionally substituted aryl and an optionally substituted heteroaryl;Y, in an orientation R.sup.2 --Y--, is selected from --(CR.sup.4.sub.2).sub.q --; --(CR.sup.4.sub.2).sub.m O(CR.sup.4.sub.2).sub.n --; --(CR.sup.4.sub.2).sub.m CH.dbd.CH(CR.sup.4.sub.2).sub.m --; --(CR.sup.4.sub.2).sub.m CH.tbd.CH(CR.sup.4.sub.2).sub.m --; --(CR.sup.4.sub.2).sub.m --A--(CR.sup.4.sub.2).sub.m -- and a cycloalkyl, where q is an integer of 0 to 4 and m and n are as defined above;R.sup.2 is selected from H, an optionally substituted aryl and an optionally substituted heteroaryl; andR.sup.3 is selected from H, optionally substituted lower allyl, optionally substituted aryl, optionally substituted heteroaryl and --NR.sup.6 R.sup.7, where R.sup.6 is selected from H and optionally substituted lower alkyl; R.sup.7 is H, optionally substituted lower alkyl, optionally substituted aryl, --(SO.sub.2)R.sup.8, --COR.sup.8 and --C(O)NH--R.sup.4, R.sup.8 is selected from optionally substituted lower alkyl, optionally substituted aryl and optionally substituted heteroaryl or R.sup.6 and R.sup.7 together with the nitrogen to which they are attached form a heteroaryl.