Patent ID: 7807366
Filing Date: 2010-10-05
Classification: C12Q

Abstract:
1. A method for predicting a risk of preterm delivery in a human subject, comprising the steps of: a) determining, in one or more nucleic acid samples from said subject, and b) predicting an increased risk of preterm delivery in the human subject if a T is detected at position −656 and the 12 base pair sequence (SEQ ID NO: 22) is detected at position −694 to −683 in said SERPINHI gene promoter, as compared to a human subject where a T is detected at position −656 and the 12 base pair (SEQ ID NO: 22) deletion is detected at positions −694 to −683 in said SERPINH1 gene promoter; and wherein said SNP at position −656 and said 12 base pair deletion at positions −694 to −683 in said SERPINHI gene promoter modulate the level of transcription of the SERPINH 1 gene.