Patent ID: 8921321
Filing Date: 2014-12-30
Classification: A61K,A61P,G01N

Abstract:
1. A method of selecting a candidate compound for use in the treatment of Alzheimer's disease in a human patient, which method comprises: (a) incubating proliferating lymphocytes of said patient in the presence of one or more pharmaceutical agent(s), wherein said proliferating lymphocytes exhibit a cell cycle regulatory defect at the G1/S phase transition and wherein said pharmaceutical agent(s) are: i) inhibitors of cell cycle re-entry or progression to the G1/S transition; or ii) inhibitors of progression of the cell cycle through the G1/S transition point; and (b) screening and selecting a compound that corrects said regulatory defect at the G1/S transition in said proliferating lymphocytes as a candidate compound for use in the treatment of Alzheimer's disease in said patient.