Patent ID: 8188130
Filing Date: 2012-05-29
Classification: A61K

Abstract:
1. A method of treating prostate cancer comprising administering to a mammalian patient in need of said treatment a first therapeutic amount of a compound or a second therapeutic amount of a pharmaceutically acceptable salt of said compound, wherein said compound is selected from the group consisting of: (Z)-5-(4-S-ethylbenzylidene)imidazolidine-2,4-dione; (Z)-5-[4-(2-thienyl)benzylidene]imidazolidine-2,4-dione; (Z)-5-(3-methoxy-4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)benzylidene)imidazolidine-2,4-dione; (Z)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione; (Z)-5-(3-methoxybenzylidene)imidazolidine-2,4-dione; (Z)-5-(4-N,N-diethylaminobenzylidene)imidazolidine-2,4-dione; (Z)-5-(2-ethoxybenzylidene)imidazolidine-2,4-dione; (Z)-5-(4-butoxybenzylidene)imidazolidine-2,4-dione; (Z)-5-(2-fluorobenzylidene)imidazolidine-2,4-dione; (Z)-5-(3-chloro-4-(prop-2-ynyloxy)-5-methoxy-benzylidene)imidazolidine-2,4-dione; (Z)-5-(3-bromo-4,5-diethoxybenzylidene)imidazolidine-2,4-dione; (Z)-5-(3-bromo-4-propoxy-5-methoxy-benzylidene)imidazolidine-2,4-dione; (Z)-5-(2,3-methylenedioxy-benzylidene)imidazolidine-2,4-dione; (Z)-5-(4-(3-methyl-butoxy)-benzylidene)imidazolidine-2,4-dione; (Z)-5-(3-chloro-4-propoxy-5-methoxy-benzylidene)imidazolidine-2,4-dione; (Z)-5-(3-fluoro-4-propoxy-5-methoxy-benzylidene)imidazolidine-2,4-dione; (Z)-5-(3-methoxy-4-(2-morpholin-4-yl-2-oxo-ethoxy)-benzylidene)imidazolidine-2,4-dione; (Z)-5-(4-(tert-butyloxy)-benzylidene)imidazolidine-2,4-dione; (Z)-5-(4-(methylthio)-benzylidene)imidazolidine-2,4-dione; (Z)-5-(3-fluoro-4-(prop-2-ynyloxy)-5-methoxy-benzylidene)imidazolidine-2,4-dione; and (Z)-5-(3-bromo-4-(prop-2-ynyloxy)-5-methoxy-benzylidene)imidazolidine-2,4-dione.