Patent ID: 6355849
Filing Date: 2002-03-12
Classification: C07B,C07C,C12C

Abstract:
A perfluoroalkylation process, comprising the steps of:reacting a compound of formula RfH, wherein Rf is a perfluoroalkyl group, and a base or a species capable of generating a base, in a polar medium, with a substrate, having a pKa at least equal to 20, added to said polar medium and carrying at least one electrophilic functional group, selected from the group consisting of carbonyl, thiocarbonyl(>C=S) optionally conjugated with one or more bonds of ethylene type and a chalcogenide carrying a leaving group, then carrying out the addition, then optionally continuing the reaction after the addition, so that, on the one hand, at least 90% of the addition of the product of formula RfH, the base, or the substrate to the polar medium to form a reaction mixture is carried out and that, on the other hand, said reaction mixture has been maintained for at least Â½ hour, including during the addition, at a temperature at most equal to âˆ’20Â° C.; or meeting at least one of the conditions herein below: limiting the water content to a value at most equal to 200 ppm; or maintaining an amount of base at most equal to 1.3 times the stoichiometric amount of said base with respect to the substrate with a temperature at most equal to 0Â° C., or else the base is at most equal to 1.1 times the stoichiometric amount of said base with a temperature at most equal to 20Â° C.