Patent ID: 7807471
Filing Date: 2010-10-05
Classification: C07K,G01N

Abstract:
1. A method of selecting an anti-IL-23 antibody, comprising panning an antibody library with a variant murine p40 subunit of IL-23 and recovering the antibody binding to the variant murine p40subunit of IL-23, wherein the variant murine p40 subunit of IL-23 comprises at least one replacement from the group consisting of: (i) replacing residues 97 and 98 of the amino acid sequence of SEQ ID NO:2 with residues 97-101 of the amino acid sequence of SEQ ID NO:1, (ii) replacing residues 135-142 of the amino acid sequence of SEQ ID NO:2 with residues 138-145 of the amino acid sequence of SEQ ID NO:1, and (iii) replacing residues 247-274 of the amino acid sequence of SEQ ID NO:2 with residues 250-269 of the amino acid sequence of SEQ ID NO:1.