Patent ID: 9195796
Filing Date: 2015-11-24
Classification: C12Q,G16B

Abstract:
1. A method for treating invasive ductal carcinoma, ductal carcinoma in situ, lobular carcinoma in situ or invasive lobular carcinoma in a human patient, the method comprising: (a) staining a breast tissue sample from the patient; (b) Identifying and isolating a stained breast tissue comprising only histologically normal cells; (c) assaying the identified and isolated breast tissue comprising only histologically normal cells for mRNA levels of malignancy-risk genes comprising BIRC5, BUB1B, CCNB1, CCNB2, CDC20, CEP55 and PRC1 to obtain a first mRNA expression profile; (d) comparing the first mRNA expression profile to a control mRNA expression profile obtainable by analyzing mRNA levels of the malignancy-risk genes in normal breast tissue; (e) observing the first mRNA expression profile is at least 2-fold higher than the control mRNA expression profile obtained from normal breast tissue; and (f) treating the patient for invasive ductal carcinoma, ductal carcinoma in situ, lobular carcinoma in situ or invasive lobular carcinoma.