Patent ID: 6407060
Filing Date: 2002-06-18
Classification: A61K,A61P

Abstract:
A method for enhancing recovery of central nervous system function in a mammal, comprising the step of:administering an effective amount of a morphogen to a mammal afflicted with a central nervous system injury selected from ischemia and trauma, wherein said morphogen comprises a dimeric protein having the property of inducing tissue-specific morphogenesis in said mammal and comprising a pair of folded polypeptides, each having an amino acid sequence having at least 70% homology with the C-terminal seven-cysteine domain of human OP-1, residues 330-431 of SEQ ID NO:5, wherein said morphogen is not transforming growth factor beta (TGF-&bgr;); wherein the effective amount of the morphogen is first administered at least 12 hours after the onset of said injury; and wherein the administration enhances the recovery of central nervous system function in the mammal.