Patent ID: 6528270
Filing Date: 2003-03-04
Classification: A61K,C07K,G01N

Abstract:
A method for identifying a compound that disrupts a protein tyrosine phosphatase polypeptide/GRB-2 adaptor polypeptide complex comprising:(a) contacting a cell that forms the complex with a compound that acts intracellularly at a concentration sufficient to disrupt the protein tyrosine phosphatase polypeptide/GRB-2 complex; (b) detecting the level of the complex present in the cell of step (a); and (c) comparing the level of the complex detected in step (b) to the level of complex present in a cell of the type in step (a) that has not contacted the compound, so that if the level detected in step (b) is less than the level present in the cell, the compound that disrupts a protein tyrosine phosphatase polypeptide/GRB-2 adaptor polypeptide complex is identified.