Patent ID: 6291656
Filing Date: 2001-09-18
Classification: C07H

Abstract:
A compound of the formula I ##STR8##or a pharmaceutically acceptable salt thereof, wherein:each R.sup.1 and R.sup.2 is independently selected from the group consisting of H and C.sub.1 -C.sub.12 alkyl, wherein one or two carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N, and are optionally substituted by 1 to 3 substituents selected from the group consisting of --C(O)OR.sup.6, --OR.sup.6, C.sub.1 -C.sub.10 alkanoyl, halo, nitro, cyano, R.sup.6, R.sup.8, --NR.sup.6 R.sup.7, --SR.sup.6, --SOR.sup.6, --SO.sub.2 R.sup.6 and --SO.sub.2 NR.sup.6 R.sup.7.R.sup.3 is H, R.sup.7, C(O)R.sup.7, C(O)R.sup.8, C(O)OR.sup.7, C(O)OR.sup.8, or (CR.sup.6 R.sup.7) .sub.m R.sup.8, wherein m is an integer ranging from 0 to 6;R.sup.4 is H or C.sub.1 -C.sub.12 alkyl, wherein one or two carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N, and are optionally substituted by 1 to 3 substituents selected from the group consisting of --C(O)OR.sup.6, --OR.sup.6, C.sub.1 -C.sub.10 alkanoyl, halo, nitro, cyano, R.sup.6, R.sup.8, --NR.sup.6 R.sup.7, --SR.sup.6, --SOR.sup.6, --SO.sub.2 R.sup.6 and --SO.sub.2 NR.sup.6 R.sup.7 ;R.sup.5 is H, --C(O)R.sup.8 or C.sub.1 -C.sub.18 alkanoyl, wherein in the alkyl portion of said alkanoyl one or two carbons optionally may be replaced by a heteroatom selected from the group consisting of O, S and N;each R.sup.6 and R.sup.7 is independently selected from the group consisting of H and C.sub.1 -C.sub.12 alkyl; andeach R.sup.8 is independently a 4-10 membered heterocyclic or C.sub.6 -C.sub.10 aryl, wherein said heterocycyclic and aryl groups are optionally substituted 1 to 3 substituents independently selected from the group consisting of 4-10 membered heterocyclic, C.sub.6 -C.sub.10 aryl, --NHC(O)R.sup.6, --NHC(O)NR.sup.6 R.sup.7, --C(O)OR.sup.6, --OR.sup.6, --C(O)R.sup.6, halo, nitro, cyano, R.sup.6, --NR.sup.6 R.sup.7,--SR.sup.6, --S(O)R.sup.6, --SO.sub.2 R.sup.6 and --SO.sub.2 NR.sup.6 R.sup.7.