Patent ID: 7985728
Filing Date: 2011-07-26
Classification: A61K,A61P,C07K

Abstract:
1. A method comprising: locally introducing a composition comprising a carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide at a particular coronary region wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport and is selected from the group consisting of: (i) An 18 amino acid peptide, DWFKAFYDKVAEKFKEAF (SEQ ID NO: 1); (ii) An 18 amino acid peptide, DWLKAFYDKVAEKLKEAF (SEQ ID NO: 2); (iii) A 33 amino acid peptide, PALEDLRQGLLPVLESFKVFLSALEEYTKKLNTQ (SEQ ID NO: 3); (iv) Ac-DWFKAFYDKVAEKFKEAF-NH (v) Ac-PALEDLRQGLLPVLESFKVFLSALEEYTKKLNTQ-NH (vi) Ac-FAEKFKEAVKDYFAKFWD-NH (vii) Ac-FAEKLKEAVKDYFAKLWD-NH (viii) Ac-NLKKTYEELASLFSVKFSELVPLLGQRLDELAP-NH (ix) Ac-LKLLDNWDSVTSTFSKLREQLGPALEDLRQGLL-NH (x) Ac-PALEDLRQGLLPKLLDNWDSVTSTFSKLREQLG-NH