Patent ID: 6127335
Filing Date: 2000-10-03
Classification: A61K,A61P,C07K

Abstract:
A cyclopeptide of formula Icyclo-(Arg-Gly-Asp-X-Y) I,and the physiologically acceptable salts thereof, whereinX is Phe, homoPhe, Phg, Phe(4-F) or Phe(4-Cl),Y is hPro, Ahds, Aos, Nhdg, Acha, Aib, Acpa or Tle,wherein, when X and Y represent optically active amino acid residues, both the D and L forms are included,wherein Arg represents arginine or N-guanidine-acyl derivatives of arginine, and wherein Asp represents aspartic acid and .beta.-esters of aspartic acid.