Patent ID: 8563682
Filing Date: 2013-10-22
Classification: A61K,C07K,C12Q,G01N

Abstract:
1. A purified compound having a structure according to formula (I) wherein: R1 is absent, or a combination of 1-50 natural amino acids, 1-50 blocked amino acids, 1-50 synthetic amino acids, 1-50 derivatized amino acids; 1-50 amino acid mimetics, a 1-50 alkyls, one or more 1-50 substituted alkyls, one or more 1-50 aryls, one or more 1-50 substituted aryls, one or more 1-50 alkylaryls, one or more 1-50 substituted alkylaryls or combinations thereof; R2 is a natural, blocked, or derivatized cysteine, wherein R2 crosslinks with R6; R3 is a natural, blocked, or derivatized cysteine, wherein R3 crosslinks with R8; R4 is one or two natural, blocked, or derivatized glutamic acid or leucine wherein R4 forms a 310-helix turn group linking R3 to R5; R5 is a natural leucine, blocked leucine, derivatized leucine, natural isoleucine, blocked isoleucine, or derivatized isoleucine; R6 is a natural, blocked, or derivatized cysteine, wherein R6 crosslinks with R2; R7 is NPA, wherein R7 forms a beta turn group linking R6 to R8, R8 is a natural, blocked, or derivatized cysteine, wherein R8 crosslinks with R3; R9 is absent, or a combination of 1-50 natural amino acids, 1-50 blocked amino acids, 1-50 synthetic amino acids, 1-50 derivatized amino acids; 1-50 amino acid mimetics, a 1-50 alkyls, one or more 1-50 substituted alkyls, one or more 1-50 aryls, one or more 1-50 substituted aryls, one or more 1-50 alkylaryls, one or more 1-50 substituted alkylaryls or combinations thereof that does not crosslink to R5.