Patent ID: 6033669
Filing Date: 2000-03-07
Classification: A61K,A61P,C07H,C07K,C12N

Abstract:
A method of stimulating the generation of cytotoxic T cells (CTLs) in a patient, wherein said CTLs have the potential to destroy or attenuate cells presenting a characteristic disease-associated carbohydrate structure, which comprises administering to the patient an effective dose of a peptide/carbohydrate conjugate capable of generating cytotoxic T cell immunity against a carbohydrate structure, said conjugate comprising (i) a peptide component capable of binding an MHC class I molecule; and (ii) a carbohydrate component comprising the immunogenic specificity of said disease-associated carbohydrate structure and being of a size that enables a T cell receptor to encompass an epitope of said disease-associated carbohydrate structure.