Patent ID: 9035077
Filing Date: 2015-05-19
Classification: C07D

Abstract:
1. A method for manufacturing molecules of Formula F: the method comprising the steps of: reacting a first mixture comprising cyclohexenone, an alkylating agent and a methyl vinyl ketone (MVK) equivalent to form a first synthetic intermediate of Formula B: wherein R reacting a second mixture comprising the intermediate of Formula B and a formylating agent under basic conditions to form an aldehyde intermediate of Formula C: reacting a third mixture comprising the intermediate of Formula C and a dienophile under [4+2] reaction conditions to form an intermediate of Formula D: wherein: R X reacting a fourth mixture comprising intermediate D and an MVK converting agent to form an intermediate of Formula E: wherein the MVK converting agent reacts with the moiety Y of compound D to convert moiety Y to a —CH 2 CH 2 C(O)CH 3 moiety; and reacting a fifth mixture comprising the intermediate of Formula E, hydrogen peroxide and a metal catalyst to form molecules of Formula F.