Patent ID: 9207238
Filing Date: 2015-12-08
Classification: A61K,A61P,C07K,C12N,C12P,G01N

Abstract:
1. A monoclonal antibody or an antibody fragment thereof, which competes with one antibody selected from the following (a)-(c) to specifically recognize human FOLR1 of SEQ ID NO:1; which binds to an epitope identical to the epitope on human FOLR1 to which one antibody selected from the following (a)-(c) binds; and which shows an anti-tumor activity: (a) an antibody in which complementarity determining regions (CDRs) 1-3 of heavy chain (H chain) of the antibody comprise the amino acid sequences of SEQ ID NOs. 30, 31, and 32, respectively and CDRs 1-3 of light chain (L chain) of the antibody comprise the amino acid sequences of SEQ ID NOs. 33, 34, and 35, respectively; (b) an antibody in which CDRs 1-3 of H chain of the antibody comprise the amino acid sequences of SEQ ID NOs. 30, 31, and 32, respectively and CDRs 1-3 of L chain of the antibody comprise the amino acid sequences of SEQ ID NOs. 33, 34, and 35, respectively, and in which cysteine in the amino acid sequence of SEQ ID NO. 32 is substituted with threonine, methionine, isoleucine, valine, phenylalanine, or glutamine; and (c) an antibody in which H chain of the antibody comprises the amino acid sequence of SEQ ID NO. 98, and L chain of the antibody comprises the amino acid sequence of SEQ ID NO. 94.