Patent ID: 7892518
Filing Date: 2011-02-22
Classification: C07B,C07C,C07D,C07H

Abstract:
1. A method of fluorination which comprises fluorinating a substrate by bringing the substrate and a complex compound comprising HF and a base into reaction with each other under irradiation with at least one of microwaves and electromagnetic waves having a wavelength around a microwave region; wherein the substrate is selected from the group consisting of a compound having a hydrogen atom activated by a substituent at the α position, the β-position or the γ-position, a silyl ether compound, a compound having an unsaturated group, hydroxyl group, halogeno group, amino group, diazo group, triazeno group or isocyano group as a functional group, a saccharide and a cyclic compound having a three-membered or greater ring which may have a heteroatom, wherein the fluorination is conducted in the presence of an agent accelerating a reaction, and wherein the agent accelerating a reaction comprises n-bromosuccinimide, 1,3-dibromo-5,5-dimethylhidantoin, sulfur chloride or a sulfuryl compound.