Patent ID: 6271241
Filing Date: 2001-08-07
Classification: C07D,G01N

Abstract:
A compound of the formula: ##STR26##or pharmaceutically acceptable non-toxic salts thereof wherein:R.sub.7 represents H, or C.sub.1 -C.sub.6 alkyl;when R.sub.7 is H, R.sub.1 is not 3-fluorobenzyl and R.sub.1 represents 2-, 3-, or 4-picolyl or benzyl, each of which is optionally mono-, di-, or trisubstituted independently withhalogen, nitro, trifluoromethyl, cyano, hydroxyl, C.sub.1 -C.sub.6 alkoxy, or C.sub.1 -C.sub.6 alkyl;amino, mono or di(C.sub.1 -C.sub.6)alkylamino, amino(C.sub.1 -C.sub.6)alkyl, or mono- or di(C.sub.1 -C.sub.6)alkylamino(C.sub.1 -C.sub.6)alkyl, or mono- or di (C.sub.1 -C.sub.6)alkylamino(C.sub.1 -C.sub.6)alkoxy;--O(CH.sub.2).sub.n CO.sub.2 R.sub.8 where n is 1,2,3,4, NR.sub.8 COR.sub.9, COR.sub.8, CONR.sub.8 R.sub.9 or CO.sub.2 R.sub.8 where R.sub.8 and R.sub.9 are the same or different and represent hydrogen or C.sub.1 -C.sub.6 alkyl or NR.sub.8 R.sub.9 forms a 5-, 6- or 7-membered heterocycloalkyl ring;SO.sub.2 R.sub.8, NHSO.sub.2 R.sub.8, SO.sub.2 NHR.sub.8, SO.sub.2 NHCOR.sub.8, CONHSO.sub.2 R.sub.8 where R.sub.8 is as defined above;O(CH.sub.2).sub.n -G where n=1,2,3,4 and G represents SO.sub.2 R.sub.8, NHSO.sub.2 R.sub.8, SO.sub.2 NHR.sub.8, SO.sub.2 NHCOR.sub.8, CONHSO.sub.2 R.sub.8, where R.sub.8 is as defined above; ortetrazole, triazole, imidazole, thiazole, oxazole, thiophene, or pyridyl; andwhen R.sub.7 represents C.sub.1 -C.sub.6 alkyl, R.sub.1 represents C.sub.1 -C.sub.6 alkyl, cyclopentyl, or cyclopropylmethyl; andR.sub.2 representshydrogen or hydroxy;C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, each of which is optionally substituted with amino or mono- or di(C.sub.1 -C.sub.6)alkylamino, C.sub.5 -C.sub.7 cycloalkylamino or C.sub.5 -C.sub.7 cycloalkoxy; orO(CH.sub.2).sub.n CO.sub.2 R.sub.8 where n=1,2,3,4, NR.sub.8 COR.sub.9, COR.sub.8, CONR.sub.8 R.sub.9 or CO.sub.2 R.sub.8 where R.sub.8 and R.sub.9 are the same or different and represent hydrogen or C.sub.1 -C.sub.6 alkyl or NR.sub.8 R.sub.9 forms 5-, 6-, or 7-membered heterocyclic ring;R.sub.3 represents C.sub.1 -C.sub.6 alkyl;R.sub.4 represents C.sub.1 -C.sub.6 alkoxy; orR.sub.4 can represent methyl when R.sub.1 and R.sub.7 are lower alkyl;R.sub.5 and R.sub.6 are the same or different and representhydrogen or halogen;C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, the alkyl portion of each being optionally substituted with amino, mono- or di(C.sub.1 -C.sub.6)alkylamino, or a C.sub.5 -C.sub.7 heterocycloalkyl group where the heteroatom is nitrogen and the nitrogen is attached to the parent alkyl portion;O(CH.sub.2).sub.n CO.sub.2 R.sub.8 where n=1,2,3,4, NR.sub.8 COR.sub.9, COR.sub.8, CONR.sub.8 R.sub.9 or CO.sub.2 R.sub.8 where R.sub.8 and R.sub.9 are the same or different and represent hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms or NR.sub.8 R.sub.9 forms a 5-, 6- or 7-membered heterocyclic ring; toms or NR.sub.8 R.sub.9 forms a 5-, 6- or 7-membered heterocyclic ring;X represents a bond, CH.sub.2 O, or CH.dbd.CH; andA, B, C, and D are the same or different and represent CH or N with the proviso that not more than two of A, B, C and D represent N.