Patent ID: 7855076
Filing Date: 2010-12-21
Classification: A61K,C07K,C12N,G01N

Abstract:
1. A method of enhancing maturation of an immature macrophage or an immature dendritic cell that expresses Discoidin Domain Receptor 1 (DDR1), comprising: contacting the immature macrophage or the immature dendritic cell with an effective amount of a DDR1-activating antibody that specifically binds DDR1 in the presence of a differentiation agent that comprises granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), or a combination thereof, wherein the DDR1-activating antibody enhances the differentiation agent-mediated maturation of the immature macrophage or the immature dendritic cell, thereby enhancing maturation of the immature macrophage or the immature dendritic cell that expresses DDR1.