Patent ID: 6468990
Filing Date: 2002-10-22
Classification: A61K,A61P,C07D

Abstract:
A method of inhibiting the binding of neive growth factor to the p75NTR receptor, comprising contacting cells expressing the p75NTR receptor with an effective inhibiting amount of a compound of Formula 3, whereinD1, D2, E1, E2, E3, E4 and G are each, independently, an Sp2-hybridized carbon or nitrogen atom; one of X1 and X2 is a hydrogen atom, while the other is an electronegative atom or an electronegative functional group; R and R2 are each, independently, an electronegative atom or an electronegative functional group; Y, Y1, Y2, and Y3 are each, independently, N, O, S, Câ€”L or Nâ€”L, where L is H, alkyl or an electronegative atom or functional group; T1 and T2 are each, independently, an sp2- or sp3-hybridized carbon or nitrogen atom; d, h and c are each 0 or 1; and R1 is a monocyclic or polycyclic aryl or heteroaryl, monosaccharide or oligosaccharide which is substituted with at least one acid functional group.