Patent ID: 9193751
Filing Date: 2015-11-24
Classification: C07C,C07D,C07H

Abstract:
1. A method of preparing a compound of Formula Ia: the method comprising: (a) forming a first reaction mixture comprising a compound of Formula IIa:  an alkyl-magnesium complex selected from the group consisting of C  wherein the first reaction mixture is at a temperature of less than about −50° C., to afford an intermediate compound; (b) forming a second reaction mixture comprising the intermediate compound, a second organic solvent, and a compound of Formula IIIa:  to afford the compound of Formula Ia wherein R (c) forming a third reaction mixture comprising a C (d) forming a fourth reaction mixture comprising a reducing agent and the compound of Formula Ia wherein R wherein X is iodo, R R R R each R R wherein the alkyl, alkoxy, cycloalkyl, and cycloalkoxy groups or portions thereof may optionally be partially or completely fluorinated, and one or more hydrogen atoms optionally may be replaced with deuterium.