Patent ID: 6773928
Filing Date: 2004-08-10
Classification: G01N,Y10S

Abstract:
A composition of matter, comprising:a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface, wherein said molecularly compact polymer comprises a fifth-generation (G5) polyamidoamine dendrimer having surface functional groups, wherein said surface functional groups comprise about 75% hydroxyl groups and about 25% primary amine groups, and wherein said ligand is selected from the group consisting of T-helper cell CD4 molecule, Fc receptor, Acetylcholine receptor (AChR), T cell receptor for antigen, insulin receptor, hormone receptor, antibodies, antibody fragments, IgG molecules, Fab antibody molecules, polypeptides, DNA fragments, RNA fragments, hormones, insulin, hCG, enzymes, sialic acid, porphyrins, and nucleotides, and wherein said ligand is bound to said molecularly compact polymer and said molecularly compact polymer binds to said surface such that said ligand is substantially uniformly positioned opposite said surface.