Patent ID: 6696449
Filing Date: 2004-02-24
Classification: A61P,C07C,C07D

Abstract:
A compound or salt thereof, wherein: the compound corresponds in structure to Formula 15.1:A is selected from the group consisting of: a bond, â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”N(Rk)â€”, â€”C(O)â€”N(Rk)â€”, â€”N(Rk)â€”C(O)â€”, â€”C(O)â€”O-, â€”Oâ€”C(O)â€”, â€”Oâ€”C(O)â€”Oâ€”, â€”C(H)&boxH;C(H)â€”, â€”Câ‰¡Câ€”, â€”N&boxH;Nâ€”, â€”N(H)â€”N(H)â€”, â€”N(H)â€”C(O)â€”N(H)â€”, â€”C(S)â€”N(Rk)â€”, â€”N(Rk)â€”C(S)â€”, â€”C(H)2â€”, â€”Oâ€”C(H)2â€”Oâ€”, â€”C(H)2â€”Oâ€”, â€”Sâ€”C(H)2â€”, and â€”C(H)2â€”Sâ€”; R is selected from the group consisting of alkyl, alkoxyalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, heterocycloalkoxyalkyl, aryloxyalkyl, heteroaryloxyalkyl, arylthioalkyl, heteroarylthioalkyl, cycloalkylthioalkyl, and heterocycloalkylthioalkyl, wherein: the aryl, heteroaryl, cycloalkyl, or heterocycloalkyl is each optionally and independently substituted with up to two substituents selected from the group consisting of halogen, nitro, hydroxy, amino, alkyl, perfluoroalkyl, trifluoromethylalkyl, hydroxyalkyl, alkoxy, perfluoroalkoxy, perfluoroalkylthio, alkoxycarbonylalkyl, C1-C2-alkylenedioxy, hydroxycarbonylalkyl, hydroxycarbonylalkylamino, alkanoylamino, and alkoxycarbonyl; E is absent or selected from the group consisting of: a bond, â€”C(O)â€”, â€”C(O)â€”Rgâ€”, â€”Rgâ€”C(O)â€”, â€”C(O)â€”N(Rk)â€”, â€”N(Rk)â€”C(O)â€”, â€”S(O)2â€”, â€”S(O)2â€”Rgâ€”, â€”Rgâ€”S(O)2â€”, â€”N(Rk)â€”S(O)2â€”, and â€”S(O)2â€”N(Rk)â€”; Y is absent when B is absent, or Y is selected from the group consisting of hydrogen, hydroxy, nitrile, nitro, alkyl, haloalkyl, aminoalkyl, alkoxy, perfluoroalkoxy, cycloalkyl, aryl, aralkyl, heteroaryl, aryloxy, aralkoxy, heteroaryloxy, heteroaralkyl, Rg-oxyalkyl, perfluoroalkylthio, alkenyl, heterocycloalkyl, and alkoxycarbonyl, wherein: the aryl, heteroaryl, or heterocycloalkyl optionally is substituted with up to two substituents independently selected from the group consisting of halogen, nitro, nitrile, alkyl, haloalkyl, alkoxy, and aminoalkanoyl, aralkyl, and aryl, wherein: the amino nitrogen optionally is substituted with up to two substituents independently selected from alkyl and aralkyl; as to R5 and R6: R5 and R6 are not both hydrogen, and are independently selected from the group consisting of hydrogen, halogen, nitro, hydroxy, cyano, alkyl, haloalkyl, hydroxyalkyl, acylalkyl, cycloalkyl, alkoxy, haloalkoxy, and N(Rb)(Rc)-alkyl, or R5 and R6, together with the atoms to which they are bonded, form a 5 or 6 membered alkylene dioxy ring; Rb and Rc are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, carboxyalkyl, hydroxyalkyl, aminoalkyl, alkenyl, alkynyl, alkoxyalkyl, bisalkoxyalkyl, perfluoroalkoxyalkyl, alkanoyl, haloalkanoyl, hydroxyalkanoyl, thiolalkanoyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, alkyliminocarbonyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, aryloxyalkyl, aryloxycarbonyl, arylsulfonyl, aralkanoyl, aroyl, aryliminocarbonyl, heterocyclo, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, heteroaryloxyalkyl, heteroarylalkoxyalkyl, heteroarylthioalkyl, alkylsulfonyl, heteroarylsulfonyl, heterocycloiminocarbonyl, arylthioalkyl, alkylthioalkyl, arylthioalkenyl, alkylthioalkenyl, heteroarylalkyl, aminoalkylcarbonyl, aminosulfonyl, and aminoalkylsulfonyl, wherein any amino nitrogen of Rb or Rc is: unsubstituted, substituted with 1 or 2 Rd substituents, or substituted with substituents such that the substituents, taken together with the amino nitrogen, form either: a saturated or partially saturated heterocyclo optionally substituted with up to three Rd substituents, or a heteroaryl optionally substituted with up to three Rf substituents; each Rd and Re is independently selected from the group consisting of hydrogen, alkyl, alkenyl, arylalkyl, aryl, alkanoyl, aroyl, arylalkylcarbonyl, alkoxycarbonyl, and arylalkoxycarbonyl; each Rf is independently selected from the group consisting of halogen, cyano, nitro, hydroxy, alkyl, alkoxy, aryl, and â€”N(Rd)(Rc); Rg is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, amino, carboxy, alkyl, perfluoroalkyl, trifluoroalkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, aldehydo, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkanoyl, alkylthio, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclo, aroyl, heteroaroyl, aryloxy, heteroaryloxy, alkoxyaryl, alkoxyheteroaryl, alkylenedioxy, aryloxyalkyl, arylthio, alkoxycarbonyloxy, aryloxycarbonyl, arylalkoxycarbonyl, arylalkoxycarbonylamino, aryloxycarbonyloxy, â€”N(Rh)(Ri), N(Rh)(Ri)-carbonyloxy, N(Rh)(Ri)-carbonyl, N(Rh)(Ri)-alkanoyl, hydroxyaminocarbonyl, â€”N(Rh)(Ri)-sulfonyl, N(Rh)(Ri)-carbonyl-N(Rh)â€”, trifluoromethylsulfonyl-N(Rh)â€”, heteroarylsulfonyl-N(Rh)â€”, arylsulfonyl-N(Rh)â€”, arylsulfonyl-N(Rh)-carbonyl, alkylsulfonyl-N(Rh)â€”, arylcarbonyl-N(Rh)-sulfonyl, and alkylsulfonyl-N(Rh)-carbonyl; each Rh is independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, carboxyalkyl, unsubstituted aminoalkyl, substituted aminoalkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxycarbonyl, arylalkyl, alkanoyl, haloalkanoyl, unsubstituted aminoalkanoyl, substituted aminoalkanoyl, aryl, arylalkoxycarbonyl, aroyl, heteroaryl, and heterocyclo, wherein: each such group (including the substituents of any substituted amino alkyl or aminoalkanoyl) optionally is substituted by up to two Rj substituents R1 is selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, carboxyalkyl, unsubstituted aminoalkyl, substituted aminoalkyl, alkoxyalkyl, alkoxycarbonyl, alkenyl, alkynyl, alkanoyl, haloalkanoyl, unsubstituted aminoalkanoyl, substituted aminoalkanoyl, aryl, arylalkyl, arylalkoxycarbonyl, aroyl, heteroaryl, and heterocyclo, wherein: each Ri group may be optionally and independently substituted with up to two Rj substituents; each Rj is independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, carboxyalkyl, unsubstituted aminoalkyl, substituted aminoalkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxycarbonyl, alkanoyl, haloalkanoyl, unsubstituted aminoalkanoyl, substituted aminoalkanoyl, aryl, arylalkyl, arylalkoxycarbonyl, aroyl, heteroaryl, and heterocyclo, wherein: the substituents of the substituted aminoalkyl or substituted aminoalkanoyl are independently selected from the group consisting of alkyl, alkenyl, alkoxycarbonyl, aryl, arylalkyl, aryloxycarbonyl, heteroaryl, and heteroarylalkyl; and Rk is selected from the group consisting of hydrogen, alkyl, alkenyl, alkoxycarbonyl, aryl, arylalkyl, aryloxycarbonyl, heteroaryl, heteroarylalkyl, N(Rc)(Rd)-carbonyl, N(Rc)(Rd)-sulfonyl, N(Rc)(Rd)-alkanoyl, and N(Rc)(Rd)-alkylsulfonyl.