Patent ID: 6884786
Filing Date: 2005-04-26
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An antitumoral composition for the treatment of an HPV related cancerous or precancerous condition, wherein the composition comprises at least one recombinant vector, or a viral particle comprising said recombinant vector, wherein said recombinant vector comprises a sequence encoding at least one immunogenic polypeptide selected from the group consisting of the E6 polypeptide of the HPV-16 papillomavirus and the E7 polypeptide of the HPV-16 papillomavirus, wherein said immunogenic polypeptide is modified by inserting a membrane anchoring sequence and a secretory sequence, so as to have a membrane location at the surface of the cells in which it is expressed, wherein said vector is a non-integrative vector, and wherein said immunogenic polypeptide naturally has a nuclear location and wherein its natural nuclear localization sequence is deleted.