Patent ID: 8685415
Filing Date: 2014-04-01
Classification: A61K,A61P,C12N

Abstract:
1. A mycobacterium comprising a genetically engineered mutation in at least one endogenous gene selected from the group consisting of SapM, endogenous ManLAM α-1,2-mannosyltransferase corresponding to Mb1661c in Mycobacterium bovis , endogenous ManLAM α-1,2-mannosyltransferase corresponding to Mb2203 in Mycobacterium bovis , and endogenous LM α-1,6-mannosyltransferase corresponding to Mb2196 in Mycobacterium bovis , wherein, if the gene is SapM, the genetically engineered mutation is created by insertional mutagenesis.