Patent ID: 7273610
Filing Date: 2007-09-25
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody comprising a heavy chain (HC) immunoglobulin variable domain sequence comprising an HC CDR1, an HC CDR2, and an HC CDR3, and a light chain (LC) immunoglobulin variable domain sequence comprising an LC CDR1, an LC CDR2, and an LC CDR3, wherein all of said HC CDR1, HC CDR2, HC CDR3, LC CDR1, LC CDR2, and LC CDR3 are selected from any one antibody selected from the group consisting of A2, B5, D2, D5, F8, H10, and C9; and wherein the HC and LC immunoglobulin variable domain sequences form an antigen binding site that specifically binds to human endotheliase-2 (ET2) of SEQ ID NO:2 or SEQ ID NO:94.