Patent ID: 8110196
Filing Date: 2012-02-07
Classification: A61K,A61P,C12N,G01N,Y02A

Abstract:
1. A method of modulating the immune response to one or more viruses in a subject in need thereof comprising administering to the subject a plurality of compositions in amounts effective to modulate said immune response, each composition being administered to a different site of the subject wherein each composition comprises at least one purified antigenic molecule, wherein at least one purified antigenic molecule in each composition comprises a set of one or more epitopes of one or more viral strains, and wherein the one or more purified antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition so administered, wherein the distance between each pair of sites is greater than the distance between any two anatomically distinct lymph nodes or groups of lymph nodes nearest each site and wherein the distinct epitopes between the compositions differ from each other by an epitopic variance defined as the sum of the number of non-conservative amino acid changes and one half of the number of conservative amino acid changes divided by the total number of amino acids in the epitope, and wherein the epitopic variance between the distinct epitopes between the compositions is between 0.05-0.5.