Patent ID: 8425915
Filing Date: 2013-04-23
Classification: A61K,A61P,B82Y,Y02A

Abstract:
1. A nanoparticle which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including: (a) a first ligand comprising a carbohydrate residue capable of stimulating an innate immune response; (b) a second ligand comprising a T cell helper peptide; (c) a third ligand comprising a danger signal selected from the group consisting of endotoxins, heat-shock proteins, nucleotides, reactive oxygen intermediates, extracellular-matrix breakdown products, neuromediators, cytokines and lipid moieties, wherein said danger signal is a toll-like receptor agonist; and (d) one or more ligands capable of producing a specific response to a target infectious agent, wherein the nanoparticle further comprises a corona of ligands comprising carbohydrate groups capable of shielding the nanoparticles from recognition by an immune system, so that the immune response produced by the nanoparticle in vivo is specific to the target infectious agent.