Patent ID: 6011052
Filing Date: 2000-01-04
Classification: C07D

Abstract:
A compound of Formula I ##STR16## where: R.sub.1, R.sub.2 can be independently H,C.sub.1-20 alkyl,C.sub.5-7 cycloalkyl,--(CH.sub.2).sub.n NR.sub.6 R.sub.7--(CH.sub.2).sub.0-6 CONR.sub.6 R.sub.7,--(CH.sub.2).sub.n OH,--(CH.sub.2)0-6CO.sub.2 R.sub.11 ;biphenyl,aryl of from 6 to 10 carbon atoms, oraryl of from 6 to 10 carbon atoms substituted up to 3 times by halogen, --CN, lower alkyl offrom 1-4 carbon atoms, --OH, nitro, --SO.sub.2 H, --SO.sub.2 lower alkyl,--SO.sub.2 NR.sub.6 R.sub.7, lower alkoxy,--CO.sub.2 R.sub.11,--CONR.sub.6 R.sub.7,--NR.sub.6 R.sub.7, or--CH.sub.2 OH;wherein n is an integer from 0-6 providing n is not 1 when the moiety is R.sub.1, R.sub.2, R.sub.4 and/or R.sub.5 and n can not be 0 when the moiety is R.sub.4 or R.sub.5 ;R.sub.6 and R.sub.7 can be independentlyH, lower alkyl of from 1-4 carbon atoms, or(CH.sub.2).sub.n NR.sub.8 R.sub.9 ;R.sub.8 and R.sub.9 can independently by H or lower alkyl;R.sub.10 is H, alkyl of from 1-4 carbon atoms, (CH.sub.2).sub.n Ph, or (CH.sub.2).sub.n CHPH.sub.2 where ""Ph"" is phenyl;R.sub.11 is H or lower alkyl of from 1-4 carbon atoms;R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 can independently be taken together to form a ring of 5-7 atoms;further either one of R.sub.1 or R.sub.2 can independently be--C(O)R.sub.12,--C(S)R.sub.12 or,--CO.sub.2 R.sub.12,where R.sub.12 is lower alkyl of from 1-4 carbon atoms, phenyl or phenyl substituted up to 3 times with substituents as previously defined above;R.sub.3 is --C(O)NH(CH.sub.2).sub.n NR.sub.6 R.sub.7,R.sub.4 can be independently H, or C.sub.1-20 alkyl;R.sub.5 can be independently H, C.sub.1-20 alkyl, C.sub.5-7 cycloalkyl;aryl of from 6 to 10 carbon atoms, oraryl of from 6 to 10 carbon atoms substituted up to 3 times by halogen, --CN, lower alkyl offrom 1-4 carbon atoms, --OH, nitro, --SO.sub.2 H, --SO.sub.2 lower alkyl,--SO.sub.2 NR.sub.6 R.sub.7, lower alkoxy,--CO.sub.2 R.sub.11,--CONR.sub.6 R.sub.7,--NR.sub.6 R.sub.7, or--CH.sub.2 OH.