Patent ID: 8084472
Filing Date: 2011-12-27
Classification: A61P,C07D,C09B

Abstract:
1. A method of treating pathogenic angiogenesis associated with a disease or disorder selected from hematologic malignancy, solid tumors, endometriosis, macular degeneration, retinopathy, diabetic retinopathy, psoriasis, hemangioblastoma, chronic arthritis, pulmonary fibrosis, abnormal wound healing, myelofibrosis, and atherosclerosis, comprising administering a therapeutically effective amount of a fused pyrrolocarbazole VEGFR inhibitor compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein: ring A together with the carbon atoms to which it is attached, is a 5-membered aromatic ring in which from 1 to 2 carbon atoms may be replaced by nitrogen atoms; R R R R R at least one of R the other R Q is selected from an optionally substituted C R R R R R R R R R R R R R R R R R R p is independently selected from 1, 2, 3, and 4; y is independently selected from 0, 1 and 2.