Patent ID: 8022091
Filing Date: 2011-09-20
Classification: A61P,C07D

Abstract:
1. A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, wherein A represents an oxygen atom; R 1 represents: a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms and optionally substituted with a substituent(s) selected from the group consisting of: a hydroxyl group, a halogen atom, an alkoxy group having from 1 to 6 carbon atoms, said alkoxy group optionally substituted with a phenyl group, and a phenyl group, optionally substituted with a substituent(s) selected from the group consisting of a halogen atom and an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, an alkenyl group having from 2 to 8 carbon atoms, an alkynyl group having from 2 to 8 carbon atoms, or a phenyl group; R 1A represents: a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; R 1 and R 1A optionally form, together with a carbon atom to which said R 1 and R 1A are attached, a cycloalkyl group having from 3 to 6 carbon atoms; R 2 represents: a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 8 carbon atoms, an alkynyl group having from 2 to 8 carbon atoms, or a cycloalkyl group having from 3 to 6 carbon atoms; R 3 represents a phenyl group substituted at 3 position with a substituent selected from the group consisting of nitrogen-containing groups (i)-(v) below, said phenyl group further optionally substituted at 4 position with a halogen atom: (i) a monocylic saturated hydrocarbon group having from 2 to 7 carbon atoms and having a nitrogen atom(s) as a ring atom(s), said saturated hydrocarbon group optionally substituted with an alkyl group(s) having from 1 to 6 carbon atoms, (ii) a nitrogen-containing monocylic unsaturated hydrocarbon group, (iii) a morpholinyl group optionally substituted with an alkyl group(s) having from 1 to 6 carbon atoms, (iv) a piperazino group, optionally substituted with an alkanoyl group having from 2 to 7 carbon atoms or an alkyl group having from 1 to 6 carbon atoms and optionally substituted with a substituent(s) selected from the group consisting of: (v) Formula —NR R R 4 represents: a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and optionally substituted with a carboxyl group; R 5 represents: (i) an alkyl group having from 1 to 10 carbon atoms, (ii) an alkyl group having from 1 to 10 carbon atoms and substituted with 1 to 2 substituents selected from the group consisting of: a cycloalkyl group having from 3 to 8 carbon atoms, a pyridyl group, and a phenyl group, a phenoxy group, and a naphthyl group, each optionally substituted with 1 to 2 substituents selected from the group consisting of a halogen atom and an alkoxy group having from 1 to 6 carbon atoms, (iii) a cycloalkyl group having from 3 to 8 carbon atoms, (iv) an alkenyl group having from 2 to 8 carbon atoms, (v) an alkenyl group having from 2 to 8 carbon atoms and substituted with a phenyl group, (vi) an alkynyl group having from 2 to 8 carbon atoms, (vii) an alkynyl group having from 2 to 8 carbon atoms and substituted with a phenyl group, or (viii) an optionally substituted aryl group.