Patent ID: 7323458
Filing Date: 2008-01-29
Classification: A61P,C07D

Abstract:
1. A benzodiazepine compound of formula I: in which the dashed lines indicate the possible presence of a double bond; R n represents 0, 1, 2, 3 or 4; R X represents S; R R R in which p=0, 1, 2, 3 or 4 and in which St represents (C 6 -C 18 )aryl; -alk-Cy—NH—SO 2 —Ar in which alk represents (C 1 -C 12 )alkyl, Cy represents (C 3 -C 12 )cycloalkyl optionally substituted with one or more substituents Su and Ar represents (C 6 -C 18 )aryl optionally substituted with one or more substituents Su; —Cy—alk-NH—SO 2 —Ar; -alk-Cy; -alk-Cy-alk′-NH—CO-alk″ in which alk′ and alk″ represent, independently, (C 1 -C 12 )alkyl; di(C 1 -C 12 )alkoxyphos-phoryl(C 1 -C 12 )alkyl; (C 6 -C 18 )aryl optionally substituted with one or more substituents Su; (C 6 -C 18 )aryloxy optionally substituted with one or more substituents Su; (C 6 -C 18 )arylcarbonyl optionally substituted with one or more substituents Su; (C 6 -C 18 )arylsulphonyl optionally substituted with one or more substituents Su; (C 6 -C 18 )aryl(C 1 -C 12 )alkoxy in which the aryl portion is optionally substituted with one or more substituents Su; saturated heterocycle optionally substituted with one or more substituents Su; (C 6 -C 18 )aryl(C 1 -C 12 )alkyl optionally substituted with one or more substituents Su; Su is hydroxyl, halogen, cyano, nitro, optionally halogenated (C or alternatively R or a pharmaceutically acceptable salt thereof with an acid or base, wherein the compounds having the following substituents are excluded: X=S; n=0; R 2 represents methyl and R 3 represents a hydrogen atom; and R 4 and R 5 together form a group —CR 6 ═CR 7 — in which CR 6 is linked to X, R 6 and R 7 together form a —(CH 2 ) 3 — or —(CH 2 ) 4 — chain or alternatively R 6 represents a hydrogen atom or a propyl group and R 7 is a phenyl group optionally substituted with —OCH 3 or a hydroxyl group.