Patent ID: 7892566
Filing Date: 2011-02-22
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A polynucleotide which encodes a polypeptide comprising an ahpC polypeptide sequence, a gsd polypeptide sequence, a p12 polypeptide sequence and an mpa polypeptide sequence, wherein said ahpC polypeptide comprises: (ai) the sequence of SEQ ID NO: 2, (aii) a variant of SEQ ID NO: 2 having more than 70% amino acid sequence identity to SEQ ID NO: 2 across the full length of SEQ ID NO: 2 which comprises at least one amino acid sequence selected from the group consisting of amino acids 48 to 56 of SEQ ID NO: 4, amino acids 90 to 101 of SEQ ID NO: 4 and amino acids 161 to 169 of SEQ ID NO: 4; or (aiii) a fragment of SEQ ID NO: 2 which comprises at least one amino acid sequence selected from the group consisting of amino acids 48 to 56 of SEQ ID NO: 4, amino acids 90 to 101 of SEQ ID NO: 4 and amino acids 161 to 169 of SEQ ID NO: 4; said gsd polypeptide comprises: (bi) the sequence of SEQ ID NO: 6, (bii) a variant of SEQ ID NO: 6 having more than 70% amino acid sequence identity to SEQ ID NO: 6 across the full length of SEQ ID NO: 6 which comprises at least one amino acid sequence selected from the group consisting of amino acids 1 to 32 of SEQ ID NO: 8, amino acids 58 to 68 of SEQ ID NO: 8, amino acids 99 to 119 of SEQ ID NO: 8, amino acids 123 to 147 of SEQ ID NO: 8, amino acids 159 to 169 of SEQ ID NO: 8, amino acids 180 to 194 of SEQ ID NO: 8, amino acids 200 to 231 of SEQ ID NO: 8, amino acids 64 to 76 of SEQ ID NO: 8, amino acids 95 to 110 of SEQ ID NO: 8, amino acids 192 to 206 of SEQ ID NO: 8 and amino acids 223 to 240 of SEQ ID NO: 8; or (biii) a fragment of SEQ ID NO: 6 which comprises at least one amino acid sequence selected from the group consisting of amino acids 1 to 32 of SEQ ID NO: 8, amino acids 58 to 68 of SEQ ID NO: 8, amino acids 99 to 119 of SEQ ID NO: 8, amino acids 123 to 147 of SEQ ID NO: 8, amino acids 159 to 169 of SEQ ID NO: 8, amino acids 180 to 194 of SEQ ID NO: 8, amino acids 200 to 231 of SEQ ID NO: 8, amino acids 64 to 76 of SEQ ID NO: 8, amino acids 95 to 110 of SEQ ID NO: 8, amino acids 192 to 206 of SEQ ID NO: 8 and amino acids 223 to 240 of SEQ ID NO: 8; said p12 polypeptide comprises: (ci) the sequence of SEQ ID NO: 10, (cii) a variant of SEQ ID NO: 10 having more than 70% amino acid sequence identity to SEQ ID NO: 10 across the full length of SEQ ID NO: 10 which comprises at least one amino acid sequence selected from the group consisting of amino acids 33 to 56 of SEQ ID NO: 12, amino acids 98 to 117 of SEQ ID NO: 12 and amino acids 3 to 10 of SEQ ID NO: 12; or (ciii) a fragment of SEQ ID NO: 10 which comprises at least one amino acid sequence selected from the group consisting of amino acids 33 to 56 of SEQ ID NO: 12, amino acids 98 to 117 of SEQ ID NO: 12 and amino acids 3 to 10 of SEQ ID NO: 12; and said mpa polypeptide comprises: (di) the sequence of SEQ ID NO: 14, (dii) a variant of SEQ ID NO: 14 having more than 70% amino acid sequence identity to SEQ ID NO: 14 across the full length of SEQ ID NO: 14 which comprises at least one amino acid sequence selected from the group consisting of amino acids 130 to 160 of SEQ ID NO: 16, amino acids 56 to 64 of SEQ ID NO: 16, amino acids 150 to 160 of SEQ ID NO: 16 and amino acids 177 to 185 of SEQ ID NO: 16; or (diii) a fragment of SEQ ID NO: 14 which comprises at least one amino acid sequence selected from the group consisting of amino acids 130 to 160 of SEQ ID NO: 16, amino acids 56 to 64 of SEQ ID NO: 16, amino acids 150 to 160 of SEQ ID NO: 16 and amino acids 177 to 185 of SEQ ID NO: 16.