Patent ID: 8394986
Filing Date: 2013-03-12
Classification: A61P,C07C,C07D

Abstract:
1. A compound selected from: [4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, [4-Chloro-2-[[4-(ethylsulfonyl)-2-methylphenyl]thio]phenoxy]-acetic acid, [4-Chloro-2-[4-(ethylsulfonyl)phenoxy]phenoxy]-acetic acid, [4-Chloro-2-[[4-(methylsulfonyl)phenyl]amino]phenoxy]-acetic acid, (4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]thio}phenoxy)acetic acid, (4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]thio}phenoxy)acetic acid, (4-Chloro-2-{[4-(methylsulfonyl)phenyl]thio}phenoxy)acetic acid, {4-Chloro-2-[(5-chloropyridin-2-yl)thio]phenoxy}acetic acid, {4-Chloro-2-[(2-chloro-4-cyanophenyl)thio]phenoxy}acetic acid, (4-Chloro-2-{[2-(methylsulfonyl)phenyl]thio}phenoxy)acetic acid, (4-Chloro-2-{[4-(methylsulfonyl)phenyl]sulfinyl}phenoxy)acetic acid, (4-Chloro-2-{[4-(methylsulfonyl)phenyl]sulfonyl}phenoxy)acetic acid, [4-Chloro-2-({4-[(methylamino)carbonyl]phenyl}thio)phenoxy]acetic acid, (2S)-2-(4-Chloro-2-{[4-(methylsulfonyl)phenyl]thio}phenoxy)propanoic acid, (2R)-2-(4-Chloro-2-{[4-(methylsulfonyl)phenyl]thio}phenoxy)propanoic acid, (2S)-2-(4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]thio}phenoxy)propanoic acid, (2S)-2-(4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]thio}phenoxy)propanoic acid, 2-(4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]thio}phenoxy)-2-methylpropanoic acid, {4-Chloro-2-[4-(methylsulfonyl)phenoxy]phenoxy}acetic acid, {4-Chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid, {4-Chloro-2-[2-chloro-4-(ethylsulfonyl)phenoxy]phenoxy}acetic acid, (2S)-2-{4-Chloro-2-[4-(methylsulfonyl)phenoxy]phenoxy}propanoic acid, (2S)-2-{4-Chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}propanoic acid, (2S)-2-{4-Chloro-2-[2-chloro-4-(ethylsulfonyl)phenoxy]phenoxy}propanoic acid, {4,5-Dichloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid, {2-[2-Chloro-4-(methylsulfonyl)phenoxy]-4,5-difluorophenoxy}acetic acid, 2-{4-Chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}-2-methylpropanoic acid, (4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]amino}phenoxy)acetic acid, (4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]amino}phenoxy)acetic acid, [2-{[2-Chloro-4-(methylsulfonyl)phenyl]thio}-4-(trifluoromethyl)phenoxy]acetic acid, (2S)-2-[2-{[2-Chloro-4-(methylsulfonyl)phenyl]thio}-4-(trifluoromethyl)phenoxy]propanoic acid, [2-{[2-Chloro-4-(ethylsulfonyl)phenyl]thio}-4-(trifluoromethyl)phenoxy]acetic acid, (2S)-2-[2-{[2-Chloro-4-(ethylsulfonyl)phenyl]thio}-4-(trifluoromethyl)phenoxy]propanoic acid, [2-({4-[(Dimethylamino)sulfonyl]phenyl}thio)-4-(trifluoromethyl)phenoxy]acetic acid, [2-[2-Chloro-4-(methylsulfonyl)phenoxy]-4-(trifluoromethyl)phenoxy]acetic acid, [2-[2-Chloro-4-(ethylsulfonyl)phenoxy]-4-(trifluoromethyl)phenoxy]acetic acid, 2-[2-[2-Chloro-4-(methylsulfonyl)phenoxy]-4-(trifluoromethyl)phenoxy]butanoic acid, [2-{4-[(Dimethylamino)sulfonyl]phenoxy}-4-(trifluoromethyl)phenoxy]acetic acid, (2S)-2-[2-{4-[(Dimethylamino)sulfonyl]phenoxy}-4-(trifluoromethyl)phenoxy]propanoic acid, {2-[2-Chloro-4-(methylsulfonyl)phenoxy]-4-fluorophenoxy}acetic acid, {2-[2-Chloro-4-(ethylsulfonyl)phenoxy]-4-fluorophenoxy}acetic acid, 2-{2-[2-Chloro-4-(methylsulfonyl)phenoxy]-4-fluorophenoxy}-2-methylpropanoic acid, (2-{[2-chloro-4-(methylsulfonyl)phenyl]thio}-4-fluorophenoxy)acetic acid, (2-{[2-Chloro-4-(ethylsulfonyl)phenyl]thio}-4-fluorophenoxy)acetic acid, 2-(2-{[2-Chloro-4-(methylsulfonyl)phenyl]thio}-4-fluorophenoxy)-2-methylpropanoic acid, (2-{2-Chloro-4-[(ethylsulfonyl)amino]phenoxy}-4-fluorophenoxy)acetic acid, (2S)-2-(4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]amino}phenoxy)propanoic acid, 2-(4-Chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]amino}phenoxy)-2-methylpropanoic acid, (2S)-2-(4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]amino}phenoxy)propanoic acid, 2-(4-Chloro-2-{[2-chloro-4-(methylsulfonyl)phenyl]amino}phenoxy)-2-methylpropanoic acid, [4-Chloro-2-(pyrimidin-5-yloxy)phenoxy]acetic acid, [4-Chloro-2-(quinolin-3-yloxy)phenoxy]acetic acid, (2-{[2-Chloro-4-(methylsulfonyl)phenyl]amino}-4-fluorophenoxy)acetic acid, (2S)-2-(2-{[2-Chloro-4-(methylsulfonyl)phenyl]amino}-4-fluorophenoxy)propanoic acid, {4-Chloro-2-[[2-chloro-4-(methylsulfonyl)phenyl](methyl)amino]phenoxy}acetic acid, {4-Chloro-2-[[2-chloro-4-(methylsulfonyl)phenyl](ethyl)amino]phenoxy}acetic acid, (2-{[2-Chloro-4-(ethylsulfonyl)phenyl]amino}-4-fluorophenoxy)acetic acid, {2-[2-Chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid, {4-Chloro-2-[4-(methylsulfonyl)-3-(trifluoromethyl)phenoxy]phenoxy}acetic acid, [4-Chloro-2-(quinolin-8-ylthio)phenoxy]acetic acid, (25)-2-[4-Chloro-2-(4-nitrophenoxy)phenoxy]-propanoic acid, (2S)-2-(2-{[2-Chloro-4-(ethylsulfonyl)phenyl]amino}-4-fluorophenoxy)propanoic acid, 2-(2-{[2-Chloro-4-(ethylsulfonyl)phenyl]amino}-4-fluorophenoxy)-2-methylpropanoic acid, [2-{[2-Chloro-4-(methylsulfonyl)phenyl]amino}-4-(trifluoromethyl)phenoxy]acetic acid, [2-{[2-Chloro-4-(ethylsulfonyl)phenyl]amino}-4-(trifluoromethyl)phenoxy]acetic acid, [2[4-(Ethylsulfonyl)benzyl]-4-(trifluoromethyl)phenoxy]acetic acid, and [4-Chloro-2-(3-cyanobenzyl)phenoxy]acetic acid, or a pharmaceutically acceptable salt thereof.