Patent ID: 8933295
Filing Date: 2015-01-13
Classification: A01K,A61K

Abstract:
1. A method of identifying and selecting an agent for use in the prevention, treatment, or amelioration of a condition selected from the group consisting of Alzheimer's disease and a tau pathology, using a transgenic mouse whose genome comprises mutant nucleic acids that encode the Swedish mutant form of human amyloid precursor protein (hAPP), the PS1 M146V mutant form of presenilin-1, and the P301L mutant form of tau, wherein the transgenic mouse exhibits decreased sorting behavior compared to a non-transgenic mouse of the same strain, the method comprising the steps of: a) providing a number of said transgenic mice; b) dividing the mice into a test group and a control group and providing each with sortable material; c) administering a test agent to mice in said test group and administering a control agent to mice in said control group; d) observing the mice in said test group and said control group for sorting behavior; e) assessing the sorting behavior, wherein a decrease in sorting behavior in the test group, as compared to the control group, is indicative of Alzheimer's disease or a tau pathology, and an increase in sorting behavior in the test group, as compared to the control group, is indicative of amelioration of symptoms associated with Alzheimer's disease or a tau pathology; and f) selecting a test agent that produces an increase in sorting behavior in the test group, as compared to the control group, as an agent for trestment of Alzheimer's disease or a tau pathology.