Patent ID: 6093727
Filing Date: 2000-07-25
Classification: A61P,C07D

Abstract:
A compound having the structure: ##STR20## wherein X is N or N.sup.+ O.sup.- ; wherein Y is CO, CR.sub.3 R.sub.5 ;wherein each R.sub.2 is independently H; F; Cl; Br; I; --NO.sub.2, --CN; straight chained or branched C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 monofluoroalkyl or C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --OH; --(CH.sub.2).sub.q OH; --COR.sub.4 ; CO.sub.2 R.sub.4 ; CONHR.sub.4 ; phenyl; or benzyl;wherein each R.sub.3 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 monofluoroalkyl or C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --(CH.sub.2).sub.q OH; --OH; .dbd.N--OR.sub.4 ; COR.sub.4 ; CO.sub.2 R.sub.4 ; CONHR.sub.4 ; phenyl; or benzyl;wherein each R.sub.4 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl or C.sub.1 -C.sub.4 polyfluoroalkyl; or phenyl;wherein each R.sub.5 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, or C.sub.1 -C.sub.4 polyfluoroalkyl;wherein R.sub.6 is H; straight chained or branched C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 monofluoroalkyl or C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --CH.sub.2 CH.sub.2 (CH.sub.2).sub.q OH; COR.sub.4 ; CO.sub.2 R.sub.4 ; CONHR.sub.4 ; phenyl; or benzyl;wherein m and n are each independently 0, 1, 2 or 3, provided that m+n is 2 or 3;wherein each p is independently 0, 1 or 2; andwherein each q is independently 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof.