Patent ID: 6362209
Filing Date: 2002-03-26
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula (I): whereinZ is oxygen; one of R and R1 is a group of the formula whereinR3 is a C1-4 alkyl, amino, or C1-4 alkylamino, and R4, R5, R6, and R7 are the same or different and each is hydrogen or fluorine provided that at least one of R4, R5, R6, and R7 is not hydrogen, and the other of R and R1 is (i) selected from the group consisting of phenyl, naphthyl, biphenyl, C5-7 cycloalkyl, thienyl, furyl, and pyrrolyl, and is (ii) unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of hydroxy, C1-4 alkyl, C1-4 alkoxy, mercapto, C1-4 alkylthio, halogen, trifluoromethyl, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, acetamido, and propionylamido; and R2 is C1-4 alkyl; or a pharmaceutically acceptable salt thereof.