Patent ID: 8658604
Filing Date: 2014-02-25
Classification: A61K,A61P,C07K

Abstract:
1. A compound of the formula (I): in which is a dipeptide made up of two different amino acid building blocks, the dipeptide being Z is an undecapeptide chain made up of eleven amino acid residues, in which P1 is selected from Nle, Ile, Aoc, hLeu, Chg, OctG, hPhe, 4AmPhe, Cha, Phe, Tyr, 2Cl-Phe, Trp, 1-NaI, or Leu; P2 is selected from Cys, Glu, Nle, Thr, or Gln; P3 is selected from Thr, Ala, or Abu; P4 is selected from Lys, Nle, Ala, Abu, or Thr; P5 is selected from Ser, AlloThr, or Dpr; P6 is selected from Ile, C P7 is Pro; P8 is selected from Pro, Ala, or Pro(4NHCOPhe); P9 is selected from Tyr, Phe, Be, Nle, Cha, Gln, Arg, Lys, H is, or Thr; P10 is selected from Cys, Arg, Nle, Gln, Lys, Met, Thr, or Ser; and P11 is selected from Tyr, Gln, Arg, Ser, Nle, 2-NaI, 2Cl-Phe, Cha, Phg, Phe, Asp, Asn, or Thr, two residues of Cys, which are present as the P2 and the P10 residues, being linked by a disulfide bridge formed by replacement of the two —SH groups in the two residues of Cys by one —S—S— group, in free form, an enantiomer or in a pharmaceutically acceptable salt form.