Patent ID: 6013648
Filing Date: 2000-01-11
Classification: A61K,A61P

Abstract:
Compounds of formula (Ib.sub.1): ##STR51## in which R'.sub.1b is a group having a formula --CH.sub.2 CHR.sub.10 NR.sub.6 R.sub.11 or --(CH.sub.2).sub.2 NR'.sub.6 R'.sub.11 ;R.sub.2 is hydrogen, a halogen or a(C.sub.1 -C.sub.4)alkyl;R.sub.4b is hydrogen, a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a halogen atom, a group --CF.sub.3, a group --OCF.sub.3 or a (C.sub.1 -C.sub.4)alkylthio;R.sub.5 is hydrogen, a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a halogen atom, a group CF.sub.3, a group OCF.sub.3 or a (C.sub.1 -C.sub.4)alkylthio;R.sub.6 is hydrogen or a (C.sub.1 -C.sub.4)alkyl;R'.sub.6 is a (C.sub.1 -C.sub.4)alkyl;R.sub.7b is a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a halogen atom, a group --CF.sub.3, a group --OCF.sub.3 or a (C.sub.1 -C.sub.4)alkylthio;R.sub.8 is a phenyl monosubstituted to tetrasubstituted by a substituent selected from the group consisting of a halogen atom, a (C.sub.1 -C.sub.4)alkyl and a (C.sub.1 -C.sub.4)alkoxy; or a polycyclic radical selected from a naphth-1-yl, a naphth-2-yl, a 1,2,3,4-tetrahydronaphth-1-yl, a 1,2,3,4-tetrahydronaphth-5-yl, an anthryl, a benzofuryl, a benzothien-2-yl, a benzothien-3-yl and a 2-, 3-, 4- or 8-quinolyl, said polycyclic radicals being unsubstituted or monosubstituted or disubstituted by a substituent selected from the group consisting of a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a (C.sub.1 -C.sub.4)alkylthio, a halogen, a cyano, a hydroxyl, a trifluoromethyl and an imidazol-1-yl;R.sub.10 and R.sub.11 together are a group selected from the group consisting of --CH.sub.2 --O--CH.sub.2 --CR.sub.12 R.sub.13 -- and --(CH.sub.2).sub.p --CR.sub.12 R.sub.13 --, in which the carbon atom substituted by R.sub.12 and R.sub.13 is bonded to the nitrogen atom;R'.sub.11 is a (C.sub.1 -C.sub.4)alkyl, or R'.sub.11 and R'.sub.6, together with the nitrogen atom to which they are bonded, form a group selected from the group consisting of morpholin-4-yl, thiomorpholin-4-yl, piperidin-1-yl and pyrrolidin-1-yl groups;R.sub.12 and R.sub.13 independently of one another are each hydrogen or a (C.sub.1 -C.sub.4)alkyl;p is 2 or 3;at least one of the groups R.sub.4b, R.sub.5 is hydrogen,or pharmaceutically acceptable salts thereof, with the proviso that;1) ifif R'.sub.1b is the group --CH.sub.2 CHR.sub.10 NR.sub.6 R.sub.11 ;R.sub.2 is hydrogen or a (C.sub.1 -C.sub.4)alkyl group;R.sub.4b and R.sub.5 are selected from a hydrogen, a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy or a halogen atom,R.sub.7b is selected from a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy or a halogen atom;then R.sub.8 is different from a phenyl group monosubstituted or disubstituted by a halogen, a (C.sub.1 -C.sub.4) alkyl, a (C.sub.1 -C.sub.4)alkoxy; from a 1- or 2-naphthyl group unsubstituted or monosubstituted or disubstituted by a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a halogen or a (C.sub.1 -C.sub.4)alkylthio;2) if R'.sub.1b is the group (CH.sub.2).sub.2 NR'.sub.6 R'.sub.11, then one of the groups R.sub.4b, R.sub.5, R.sub.7b is selected from --CF.sub.3, OCF.sub.3, or (C.sub.1 -C.sub.4)alkylthio.