Patent ID: 8278060
Filing Date: 2012-10-02
Classification: A61B,G01N

Abstract:
1. A method of treating lymphangioleiomyomatosis (LAM) in a human subject comprising (a) diagnosing a subject as having LAM by a method that comprises measuring VEGF-D concentration in a biological sample from the subject, wherein an elevated VEGF-D concentration in the sample compared to a predetermined criterion is indicative of LAM in the subject, wherein the predetermined criterion comprises VEGF-D measurements from a plurality of human subjects with tuberous sclerosis complex (TSC) or a cystic or chylous lung disorder that are free of LAM, wherein an elevated level of VEGF-D in the sample compared to the VEGF-D measurements from the human subjects that are free of LAM, is diagnostic of LAM; and (b) administering a standard of care therapeutic to the subject.