Patent ID: 8697855
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an isolated nucleic acid chosen from a DNA or RNA nucleic acid comprising a nucleotide sequence coding for a heavy chain variable domain of an antibody that is capable of binding to the CD151 protein, or coding for a heavy chain variable domain of a CD151-binding fragment of said antibody; wherein the antibody that is capable of binding to the CD151 protein is chosen from: an isolated antibody comprising: i) a light chain comprising CDR-L1, CDR-L2, and CDR-L3, wherein: CDR-L1 is chosen from SEQ ID No. 43 and SEQ ID No. 85; CDR-L2 is chosen from SEQ ID No. 44 and SEQ ID No. 86; CDR-L3 is SEQ ID No. 45; and ii) a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3, wherein CDR-H1 is chosen from SEQ ID No. 46 and SEQ ID No. 87; CDR-H2 is chosen from SEQ ID No. 47 and SEQ ID No. 88; CDR-H3 is chosen from SEQ ID No. 48 and SEQ ID No. 89; an isolated antibody comprising a light chain comprising SEQ ID No. 49 and a heavy chain comprising SEQ ID No. 50; an isolated antibody comprising a light chain comprising SEQ ID No. 95 and a heavy chain comprising SEQ ID No. 96; and an isolated antibody comprising a light chain comprising SEQ ID No. 95 and a heavy chain comprising SEQ ID No. 97.