Patent ID: 6248872
Filing Date: 2001-06-19
Classification: A61K,A61P,C12N,Y02A

Abstract:
An isolated nucleic acid molcule selected from the group consisting of: (a) a Dirofilaria immitis nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:13 and SEQ ID NO:14; (b) a Dirofilaria immitis nucleic acid molecule conprising a nucleic acid homologue of a nucleic acid molecule comprising a nuclcic acid sequence selectcd from the group consisting of SEQ ID NO:5, SEQ ID NO:8, SEQ ID NO:10, and SEQ ID NO:13, wherein said homologue comprises at least 18 contiguous nucleotides of any one of said nucleic acid sequences rcited in (b), which said homologue encodes a protein containing one or more amino acid deletions, substitutions, or insertions as compared to a protein encoded by a nucleic acid molecule having a nucleic acid sequence as recited in (b), and wherein said protein comprises at least one epitope that elicits an immune response against a protein having an amino acid sequence selected from the group consisting of SEQ ID NO:6 and SEQ ID NO:11: and (c) a Dirofilaria immitis nucleic acid molecule which is fully complementary to any said nucleic acid molecule recited in (b).