Patent ID: 6147080
Filing Date: 2000-11-14
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula: ##STR54## wherein: each of Q.sub.1 and Q.sub.2 are independently selected from phenyl, 5-6 membered aromatic heterocyclic ring systems having one nitrogen heteroatom;Q.sub.1 is substituted with 1 to 4 substituents, independently selected from halo; C.sub.1 -C.sub.3 alkyl; C.sub.1 -C.sub.3 alkyl substituted with NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ; O--(C.sub.1 -C.sub.3)-alkyl; O--(C.sub.1 -C.sub.3)-alkyl substituted with NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ; NR'.sub.2 ; OCF.sub.3 ; CF.sub.3 ; NO.sub.2 ; CO.sub.2 R'; CONR'; SR'; S(O.sub.2)N(R').sub.2 ; SCF.sub.3 ; or CN; andQ.sub.2 is optionally substituted with up to 4 substituents, independently selected from halo; C.sub.1 -C.sub.3 straight or branched alkyl; C.sub.1 -C.sub.3 straight or branched alkyl substituted with NR', NR'.sub.2, OR', CO.sub.2 R', or CONR'.sub.2 ; O--(C.sub.1 -C.sub.3)-alkyl; O--(C.sub.1 -C.sub.3)-alkyl substituted with NR', NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ; NR'.sub.2 ; OCF.sub.3 ; CF.sub.3 ; NO.sub.2 ; CO.sub.2 R'; CONR'; SR'; S(O.sub.2)N(R').sub.2 ; SCF.sub.3 ; or CN;wherein R' is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl or (C.sub.2 -C.sub.3)-alkenyl or alkynyl; andX is selected from --S--, --O--, --S(O.sub.2)--, --S(O)--, --C(O)--, --N(R)--, or --C(R).sub.2 --;each R is independently selected from hydrogen or (C.sub.1 -C.sub.3) alkyl;Y is C;A is CR';n is 1; andR.sub.1 is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl, OH, or O--(C.sub.1 -C.sub.3)-alkyl.