Patent ID: 7482155
Filing Date: 2009-01-27
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A chimeric construct comprising at least (i) a smooth muscle cell (SMC)-specific promoter operably linked with at least (ii) a muscle-specific enhancer; wherein the promoter and enhancer originate from different genes, different species, or different genes and species; said promoter is selected from the group consisting of a SMC-specific promoter comprising the 445 base pair region of the mouse SM22α promoter set forth in SEQ ID NO: 1 from positions 1 to 445; and, a SMC-specific promoter comprising the 445 base pair region of the human SM22α promoter set forth in SEQ ID NO: 14 from positions 1 to 445; and wherein said muscle-specific enhancer is selected from the group consisting of enhancers of the genes encoding: a rabbit myosin and a human creatine kinase.