Patent ID: 7414022
Filing Date: 2008-08-19
Classification: A61K,A61P,C07K,C12N,C12Y,Y10S

Abstract:
1. A recombinant Factor VII (FVII) or Factor VIIa (FVIIa) polypeptide variant having clotting activity comprising an amino acid sequence which differs from the sequence of human Factor VII (hFVII) or human Factor VIIa (hFVIIa) shown in SEQ ID NO:1 in no more than 10 amino acid residues, wherein the variant comprises at least one N-glycosylation site that is introduced by the substitution of the threonine residue in position 106 of SEQ ID NO:1 with an asparagine residue, and wherein amino acid residue positions of the variant are numbered according to SEQ ID NO:1.