Patent ID: 7781440
Filing Date: 2010-08-24
Classification: A61K,A61P,C07D

Abstract:
1. A method of inhibiting the activity of glycogen synthase kinase 3-beta (GSK3-β), which comprises administering to a patient in need of said inhibition an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C Y represents a covalent single bond, an ethenylene group, an ethynylene group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxide group, a carbonyl group, an NH group being optionally substituted by a C R1 represents a pyrimidine ring optionally substituted by a C when Y represents a covalent single bond, a methylene group optionally substituted or a carbonyl group then R2 represents a C when Y represents an ethenylene group, an ethynylene group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxide group or a nitrogen atom being optionally substituted then R2 represents a C R3 and R4 represent each independently a hydrogen atom, C R5 represents a hydrogen atom, a C when m equals 0, p equals 1, 2 or 3, when m equals 1, p equals 0, 1 or 2, when m equals 2, p equals 0 or 1; and n represents 0 to 3.