Patent ID: 6472140
Filing Date: 2002-10-29
Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
A method of screening for an agent that increases the ratio of A2M-1 mRNA to A2M-2 mRNA comprising:(a) incubating one or more test cells in the presence of a test agent, wherein said test cells are heterozygous or homozygous for the A2M-2 allele; and (b) comparing the ratio of A2M-1 mRNA to A2M-2 mRNA in said test cells to the ratio of A2M-1 mRNA to A2M-2 mRNA in one or more control cells, wherein said control cells are untreated with said test agent and said control cells carry the same number of A2M-2 alleles as said test cells; and wherein a ratio of A2M-1 mRNA to A2M-2 mRNA in said test cells significantly higher than the ratio of A2M-1 mRNA to A2M-2 mRNA in said control cells indicates that said test agent is effective.