Patent ID: 6384188
Filing Date: 2002-05-07
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
An apparatus for the removal of LPS from a solution, said apparatus comprising an LPS-binding peptide immobilized on a solid support, wherein the LPS-binding peptide is capable of interacting with LPS with an association constant greater than 105 Mâˆ’1, and consists of 22 or less amino acids which comprises at least:(a) the amino acid sequence 1-2-3-4-5-6-7-8, wherein the numbers represent any of the following amino acids: 1=C, H, K, N, Q, R, S, T, W, or Y; 2=A, F, H, I, L, M, V, or W; 3=H, K, or R; 4=A, F, H, I, K, L, M, R, V, or W; 5=A, C, F, H, I, K, L, M, N, Q, R, S, T, V, W, or Y; 6=K or R; 7=C, F, H, I, K, L, M, N, Q, R, S, T, V, W, or Y; 8=A, F, H, I, K, L, M, R, V, or W; (b) a corresponding inverse amino acid sequence.