Patent ID: 7030250
Filing Date: 2006-04-18
Classification: C07D,Y02P

Abstract:
1. A process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides of general formula (I) wherein R R their individual cis or trans diastereomers, their individual levo or dextro enantiomers, or isomeric mixtures thereof, and pharmaceutically acceptable salts thereof, which comprises a) protecting the nitrogen present in the aminosulfone of formula (II) wherein R wherein R b) introducing a sulfonamide group at position 2 of said N-protected aminosulfone (III) to obtain the sulfonamide intermediate of formula (VI) wherein R c) eliminating the nitrogen protecting group to obtain the compound of formula (I).