Patent ID: 7462712
Filing Date: 2008-12-09
Classification: A61P,C07D,Y02P

Abstract:
1. A process for the preparation of imipenem of Formula I the process comprising: a) activating a keto ester compound of Formula II, b) reacting the enol phosphate intermediate of Formula III, in situ with 2-aminoethanethiol or an acid addition salt thereof to get thienamycin ester of Formula IV, c) reacting thienamycin ester of Formula IV in situ with benzyl formimidate or an acid addition salt thereof in the presence of a base to get carboxyl protected imipenem of Formula V, d) hydrogenating the carboxyl protected imipenem of formula V obtained from step c), without isolation or purification, in an aqueous medium to obtain imipenem.