Patent ID: 6416770
Filing Date: 2002-07-09
Classification: A61K,A61Q

Abstract:
A polymer comprising at least one unit of formula (VII): wherein:A1+, which may be identical or different, is chosen from unsaturated quaternary heterocycles of formula (II): â€ƒwherein: E, G, L, and J, which may be identical or different, are each chosen from a carbon atom, an oxygen atom, a sulphur atom, and a nitrogen atom, wherein at least one of E, G, L, and J is a nitrogen atom; and further wherein when at least one of E, G, L, and J is a carbon atom, said carbon atom may optionally be substituted by at least one substituent chosen from halogen atoms, hydroxyl groups, nitro groups, cyano groups, mercapto groups, carboxyl groups, alkyl groups, monohydroxyalkyl groups, polyhydroxyalkyl groups, thioalkyl groups, cyanoalkyl groups, alkoxy groups, acyl groups, acetyloxy groups, cycloalkyl groups, optionally substituted, aryl groups, optionally substituted, alkylaryl groups, optionally substituted, and groups having the formula â€”NHRN wherein RN is chosen from a hydrogen atom, alkyl groups, monohydroxyalkyl groups, polyhydroxyalkyl groups, acetyl groups, and ureido groups; with the proviso that when at least two of said E, G, L, and J are nitrogen atoms, then at least one of said at least two of said E, G, L, and J may be substituted with a substituent chosen from a hydrogen atom, alkyl groups, monohydroxyalkyl groups, polyhydroxyalkyl groups, aryl groups, optionally substituted, and alkylaryl groups, optionally substituted; and with the further proviso that when at least two of E, G, L, and J are substituted, the substituents may optionally also form, together with the atoms to which they are attached, at least one 5- to 7-membered aromatic ring, optionally substituted; A2+, which may be identical or different, is chosen from quaternary ammoniums of formula (III): â€ƒwherein: R1 and R2, which may be identical or different, are each chosen from carboxyl groups, alkyl groups, polyhydroxyalkyl groups, thioalkyl groups, cyanoalkyl groups, alkoxy groups, acyl groups, acetyloxy groups, cycloalkyl groups, optionally substituted, aryl groups, optionally substituted, alkylaryl groups, optionally substituted, and groups having the formula â€”NHRN wherein RN is chosen from a hydrogen atom, alkyl groups, monohydroxyalkyl groups, polyhydroxyalkyl groups, acetyl groups, and ureido groups; wherein R1 and R2 may optionally also form, together with the nitrogen atom to which they are attached, at least one saturated 5- to 7-membered carbon-based ring; B1 and B2, which may be identical or different, are each chosen from hydrocarbons optionally having at least one substituent chosen from optionally substituted aromatic rings, an oxygen atom, a sulphur atom, a nitrogen atom, an â€”SOâ€” group, an â€”SO2â€” group, an â€”SO3H group, amino groups, alkylamino groups, hydroxyl groups, quaternary ammonium groups, and ureido groups, wherein said at least one substituent is bonded to or inserted in the main chain of said polymer, with the proviso that at least one of said B1 and B2 is chosen from groups other than â€”CH2â€”CHOHâ€”CH2â€”; and Xâˆ’ is chosen from halide anions and anions derived from at least one acid chosen from organic acids and inorganic acids.