Patent ID: 8420819
Filing Date: 2013-04-16
Classification: C07D

Abstract:
1. A process for crystallizing a compound of Formula (I) wherein: R R X is CH or N; and Y is CH or N, wherein X and Y are not both CH, or a tautomer, optical isomer, co-crystal, or salt thereof, the process comprising: (a) dissolving the free base of the compound of Formula (I) in a primary organic solvent to obtain a first solution; (b) adding an acid to the first solution to obtain a second solution; (c) combining an organic antisolvent with the second solution to obtain a third solution, wherein the antisolvent is miscible with the primary organic solvent and in which the compound of Formula (I) has a lesser solubility than in the primary organic solvent; (d) achieving supersaturation of the compound of Formula (I) in the third solution to obtain a supersaturated fourth solution; and (e) obtaining crystals of the compound of Formula (I) or a tautomer, optical isomer, co-crystal, or salt thereof.