Patent ID: 6699990
Filing Date: 2004-03-02
Classification: C07C,C07D

Abstract:
A 3-(2,5-Diaminophenyl)acrylamide derivative of formula (I), or a physiologically tolerated, water-soluble salt thereof, wherein R1, R2, R3 and R4 are equal or different and, independently of each other, denote hydrogen, a C1-C6-alkyl group, a C2-C4-hydroxyalkyl group or a C3-C4-dihydroxy alkyl group, or R1 and R2 or R3 and R4 together with N form a four-membered to eight-membered aliphatic ring and at least two of said R1, R2, R3 and R4 groups denote hydrogen;R5 denotes hydrogen, a halogen atom, a C1-C4-alkyl group, a C1-C4-hydroxyalkyl group or a C1-C4-alkoxy group; R6 and R7 are equal or different and, independently of each other, denote hydrogen, a C1-C2-alkoxy group, a C1-C6-alkyl, an unsaturated C3-C6-alkyl group, a C2-C4-hydroxyalkyl group, a C3-C4-dihydroxyalkyl group, a C2-C4-aminoalkyl group, C2-C4-dimethylaminoalkyl group, a C2-C4-acetylaminoalkyl group, a C2-C4-methoxyalkyl group, a C2-C4-ethoxyalkyl group, a C2-C4-cyanoalkyl group, a C1-C4-carboxyalkyl group, a C2-C4-aminocarbonylalkyl, a pyridylmethyl group, a furfuryl group, a hydrogenated furfuryl group, a substituted pyridyl group, a group of formula (II) â€ƒa group of formula (III) â€ƒor a group of formula (IV) â€ƒor R6 and R7 together with N form a ring of formula R8, R9 and R21 are equal or different and, independently of each other, denote hydrogen or a C1-C6-alkyl group; R10 denotes hydrogen, a carboxy group or an aminocarbonyl group; R11 and R12 are equal or different and, independently of each, other denote hydrogen, a hydroxyl group, an aminocarbonyl group, or methylthiomethyl group, a phenyl-substituted phenyl group, a hydroxyl-substituted phenyl group or a group of formula R13, R14, R15, R16 and R17 are equal or different and, independently of each other, denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C1-C4-alkoxy group, a C1-C4-hydroxyalkoxy group, a C1-C6-alkyl group, a C1-C4-alkylthioether group, a mercapto group, a nitro group, an amino group, an alkylamino group, a hydroxyalkylamino group, a dialkylamino group, a di(hydroxyalkyl)amino group, a (dihydroxyalkyl)amino group, a (hydroxyalkyl)alkylamino group, a trifluoromethane group, â€”C(O)H, â€”C(O)CH3, â€”C(O)CF3, â€”Si(CH3)3, a C1-C4-hydroxyalkyl group, a C2-C4-dihydroxyalkyl group or two adjacent R13 to R17 groups together form an â€”Oâ€”CH2â€”Oâ€” bridge; R18 denotes a C1-C4-alkyl group, a benzyl group or a C1-C4-hydroxyalkyl group; R19 denotes hydrogen or a C1-C6-alkyl group, and R20 denotes hydrogen, a hydroxyl group, a carboxy group, an aminocarbonyl group or hydroxymethyl group.