Patent ID: 6737537
Filing Date: 2004-05-18
Classification: C07F

Abstract:
A compound of formula I: wherein:R1 and R2 are independently chloro, iodo, or bromo, R3, R4, R5 and R6 are independently hydrogen, hydroxy, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C2-C6) alkenyl, (C3-C6) cycloalkenyl, (C1-C6) alkoxy, (C1-C6) hydroxyalkyl, or aryl, wherein the aryl can be substituted with a halo, hydroxy, or (C1-C6) alkyl, and a) when R1=R2=chloro R7 and R8 are independently hydroxy, (C2-C6) alkenyl, (C3-C6) cycloalkenyl, (C1-C6) alkoxy, methanol, n-propanol, isobutanol, t-butanol, octanol, decanol, tetradecanol, hexadecanol, aryl, wherein the aryl can be substituted with a halo, hydroxy, or (C1-C6) alkyl, or when taken together R7 and R8 form a group of the formula: wherein m is 1 to 5 and R10 and R11 are independently hydrogen, halo, hydroxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C1-C6) alkoxy, or (C1-C6) hydroxyalkyl, with the proviso that R10 and R11 are not both hydrogen or hydroxy when m=4; orb) when R1=R2=iodo R7 and R8 are independently hydroxy, (C2-C6) alkyl, (C3-C5) cycloalkyl, (C2-C6) alkenyl, (C3-C6) cycloalkenyl, (C1-C6) alkoxy, (C5-C6) hydroxyalkyl, aryl, wherein the aryl can be substituted with a halo, hydroxy, or (C1-C6) alkyl, or when taken together R7 and R8 form a group of the formula: wherein m is 1 to 5 and R10 and R11 are independently hydrogen, halo, hydroxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkoxy, or (C1-C6) hydroxyalkyl, with the proviso that R10 and R11 are not both hydroxy when m=4; orc) when R1=R2=bromo R7 and R8 are independently hydroxy, (C3-C6) alkyl, (C3-C5) cycloalkyl, (C2-C6) alkenyl, (C3-C6) cycloalkenyl, (C1-C6) alkoxy, (C2-C6) hydroxyalkyl, aryl, wherein the aryl can be substituted with a halo, hydroxy, or (C1-C6) alkyl, or when taken together R7 and R8 form a group of the formula: wherein m is 1 to 5 and R10 and R11 are independently hydrogen, halo, hydroxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkoxy, or (C2-C6) hydroxyalkyl, with the proviso that R10 and R11 are not both hydroxy when m=4; ord) when R1â‰ R2, R7 and R8 are independently hydroxy, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C2-C6) alkenyl, (C3-C6) cycloalkenyl, (C1-C6) alkoxy, (C1-C6) hydroxyalkyl, aryl, wherein the aryl can he substituted with a halo, hydroxy, or (C1-C6) alkyl, or when taken together R7 and R8 form a group of the formula: wherein m is 1 to 5 and R10 and R11 are independently hydrogen, halo, hydroxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C1-C6) alkoxy, or (C1-C6) hydroxyalkyl, with the proviso that R10 and R11 are not both hydroxy when m=4;or a pharmaceutically acceptable salt or ester thereof.