Patent ID: 8071545
Filing Date: 2011-12-06
Classification: A61K

Abstract:
1. A method for treating a malignant tumor in an organism in need thereof by reducing a stress mechanism and synergistically reducing production of thrombin in the organism, the method comprising: a. administering antinociception anesthesia to control psychic and somatic stress mechanisms and to reduce Factor VIII activity; b. administering a Factor VII inhibitor to reduce Factor VII activity in the organism, wherein the Factor VII inhibitor is selected from the group consisting of low molecular weight heparin, unfractionated heparin, reviparin, enoxaparin, dalteparin, tissue factor pathway inhibitor, Xa-tissue factor pathway inhibitor complex, nematode/hookworm anticoagulant protein (rNAPc2), anti-Factor VIIa compound, recombinant tissue factor pathway inhibitor, monoclonal anti-TF antibody, PHA-798 and compound 34 (pyrazinone TF/VIIa inhibitor); c. administering an anti-thrombin medication to the organism, wherein the anti-thrombin medication comprises a compound selected from the group consisting of hirudin, coumadin, annexin V, ximelagatran, bivalirudin, melagatran, and argatroban; and d. reducing a stressful condition selected from the group consisting of hypovolemia, hypervolemia, hypoxemia, hyperoxia, hypocarbia, and hypothermia, thereby treating the malignant tumor in the organism.