Patent ID: 6232312
Filing Date: 2001-05-15
Classification: A61K

Abstract:
A method of treating a patient with precancerous lesions, comprising administering to the patient with precancerous lesions sensitive to such treatment a pharmacologically effective amount of a synergistic combination of compound of the Formula I: ##STR3##wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, or haloalkyl;R.sub.2 is selected from the group consisting of hydrogen or alkyl;R.sub.3 and R.sub.4 are one or more members each independently chosen from the group consisting of hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbarnido, haloalkyl or cycloalkoxy;R.sub.5 is an alkylsulfonyl;m is 0 or 1;n is 0 or 1; andM is selected from the group consisting of hydroxy, substituted lower alkoxy, amino, alkylamino, dialkylamino, N-morpholino, hydroxyalkylamino, polyhydroxyamino, N-morpholino, hydroxyalkylamino, polyhydroxyamino, dialkylaminoalkylarnino, aminoalkylamino, and the group OMe, wherein Me is a cation; andcompound of the Formula II: ##STR4##wherein from two to four, inclusive, of the substituents R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are basic moieties selected from the group consisting of amino, lower alkylamino, dialkylamino wherein the alkyl moieties have from 1 to 12 carbon atoms, mono- (hydroxy-lower alkyl) amino, di-(hydroxy-lower alkyl)-amino, (hydroxy-lower alkyl)-alkyl-amino wherein the alkyl moiety has from 1 to 12 carbon atoms, (lower alkoxy-lower alkyl)-amino, lower alkenyl-amino, cyclohexyl-amino, phenyl-amino, halophenyl-amino, nitrophenyl-amino, (lower alkoxy-phenyl)-amino, [(di-lower alkyl-amino)-phenyl]-amino, benzylamino, semicarbazidyl, hydrazinyl, guanidyl, ethyleneimino, piperidyl, lower alkyl-piperidyl, lower alkoxy-piperidyl, hydroxy-piperidyl, pyrrolidyl, lower alkyl-pyrrolidyl, lower alkoxy-pyrrolidyl, hydroxy-pyrrolidyl, morpholyl, lower alkyl-morpholyl, lower alkoxy-morpholyl, hydroxy-morpholyl, tetrahydropyridyl, lower alkyl-tetrahydropyridyl, lower alkoxy-tetrahydropyridyl, hydroxy-tetrahydropyridyl, hexamethyleneimino, lower alkyl-hexamethyleneimino, lower alkoxy-hexamethyleneimino, hydroxy-hexamethyleneimino, tetrahydroquinolyl, lower alkyl-tetrahydroquinolyl, lower alkoxy-tetrahydroquinolyl, hydroxy-tetrahydroquinolyl, piperazyl, lower alkylpiperazyl, lower alkoxy-piperazyl, hydroxy-piperazyl and N'-lower alkyl-piperazyl, and the remaining substituents R.sub.6 to R.sub.9 are selected from the group consisting of hydrogen, halogen, hydroxyl, mercapto, lower alkyl, phenyl, lower alkoxy, di-lower-alkyl-amino-lower alkoxy and lower alkyl-thio, phenyl-thio, benzyl-thio, lower alkoxy-lower alkoxy, their non-toxic alkali metal salts and their non-toxic acid addition salts.