Patent ID: 6218371
Filing Date: 2001-04-17
Classification: A61K,A61P

Abstract:
A method for stimulating an immune response in a subject, comprising:administering to a subject exposed to an antigen an effective amount for inducing a synergistic antigen specific immune response of an immunopotentiating cytokine selected from the group consisting of GM-CSF, IL-2, IL-4 and IFN-.gamma., and an immunostimulatory CpG oligonucleotide having a sequence including at least the following formula:5' X.sub.1 CGX.sub.2 3'wherein the oligonucleotide includes at least 8 nucleotides wherein C is unmethylated and wherein X.sub.1 and X.sub.2 are nucleotides, wherein the cytokine is a peptide, whereby an antigen is optionally additionally administered, and wherein the antigen and the CpG oligonucleotide are not conjugated.