Patent ID: 7876108
Filing Date: 2011-01-25
Classification: C12Q,G01N

Abstract:
1. A method of performing an assay to evaluate the effect of one or more test compounds on cells, comprising: providing a device having three or more electrode arrays, each of which is associated with a well of the device, wherein each of said electrode arrays comprises two electrode structures each of which comprises multiple electrode elements and the electrode structures of each electrode array have substantially the same surface area, further wherein each array is individually addressed; attaching the device to an impedance analyzer; adding cells to two or more wells of the three or more wells of said device; adding different concentrations of a test compound to said two or more of said three or more wells comprising cells to form two or more compound wells comprising different concentrations of said test compound; providing at least one additional well as a control well to which cells are added that does not receive test compound; monitoring impedance from said two or more test compound wells and said at least one control well to obtain impedance measurements during at least one time point before and at three or more time points after adding said different concentrations of test compound to said two or more compound wells; and analyzing said impedance measurements from said two or more compound wells and said at least one control well to evaluate the effect of said test compound on cells.