Patent ID: 7993657
Filing Date: 2011-08-09
Classification: A61K,G01N

Abstract:
1. An assay for tuberculosis that is performed on a serum sample from a human subject, wherein the assay is capable of determining the likelihood that the subject has active tuberculosis or inactive tuberculosis, the assay comprising exposing antibodies in the sample to at least three different M. tuberculosis protein antigens separately immobilized on different locations on a surface, wherein the at least three different M. tuberculosis protein antigens include at least one antigen of a first type selected from the group consisting of 16 kDa antigen (product of gene rv 2031c) and ESAT-6 antigen (product of gene rv 3875), at least one antigen of a second type selected from the group consisting of Rv2626c antigen, AlaDH antigen (product of gene rv 2780) and 38 kDa antigen (product of gene rv 0934), and at least one antigen of a third type selected from the group consisting of 16 kDa antigen (product of gene rv 2031c), ESAT-6 antigen (product of gene rv 3875), Rv2626c antigen, AlaDH antigen (product of gene rv 2780) and 38 kDa antigen (product of gene rv 0934), and detecting serum antibodies to said antigens.