Patent ID: 9081016
Filing Date: 2015-07-14
Classification: C40B,G01N

Abstract:
1. A method for determination of an anti-<therapeutic monoclonal antibody> antibody (anti<TmAB>AB) in a whole blood, serum and plasma sample from a patient treated with a therapeutic monoclonal antibody (TmAB), the method comprising: a) providing a F(ab) fragment of the TmAB bound to a solid phase; b) incubating the solid phase provided in (a) with the sample, thereby binding the anti <TmAB>AB to the solid phase via the F(ab) fragment; c) incubating the solid phase obtained in (b) with a monoclonal antibody <h-Agg.-IgG>, whereby said monoclonal antibody binds to the anti<TmAB>AB, wherein said monoclonal antibody is an IgM antibody having a dissociation constant (=K d) detecting the monoclonal antibody<h-Agg.-IgG> bound in (c) and thereby determining the anti<TmAB>AB in the sample.