Patent ID: 6127129
Filing Date: 2000-10-03
Classification: B82Y

Abstract:
A method of making a biomolecule or cellular array on a metal substrate comprising:(a) depositing an .omega.-modified alkanethiol monolayer on a metal substrate;(b) reacting hydrophobic protecting groups with the monolayer;(c) patterning the monolayer to create an array of exposed metal substrate areas;(d) depositing .omega.-modified alkanethiol in the areas of exposed metal substrate, thereby yielding an array of discrete, unprotected .omega.-modified alkanethiol spots;(e) attaching biomolecules or cells to the discrete, unprotected .omega.-modified alkanethiol spots, thereby yielding an array of discrete spots having biomolecules or cells immobilized thereon;(f) removing the protecting groups of step (b); and then(g) making the monolayer resistant to non-specific protein binding wherein the method results in a biomolecule or cellular array.