Patent ID: 8669256
Filing Date: 2014-03-11
Classification: A61P,C07D

Abstract:
1. A compound according to Formula I or a pharmaceutically acceptable salt thereof, wherein: one of R1 and R2 is H; halogen; hydroxy; CN; amino; (1-2C)alkyl; (1-2C)alkylcarbonyl; (1-2C)alkoxy; or (di)[(1-2C)alkyl]amino, the alkyl group of which is optionally substituted with hydroxy; and the other R1 and R2 is H; halogen; hydroxy; CN; amino; (1-6C)alkyl; (1-6C)alkoxy; (di)[(1-6C)alkyl]amino, the alkyl group of which is optionally substituted with one or more hydroxy, (di)[(1-4C)alkyl]amino, (1-6C)alkoxy, (2-5C)heterocycloalkyl or (2-5C)heteroaryl; (1-6C)alkylcarbonyl; (2-5C)heterocycloalkyl, optionally substituted with one or more groups selected from hydroxy, amino, (1-6C)alkyloxycarbonylamino or (1-6C)alkyl, the alkyl group of which is optionally substituted with hydroxy; (2-5C)heteroaryl or (2-5C)heteroarylamino, both optionally substituted with halogen, CN, (1-6C)alkoxy, (di)[(1-6C)alkyl]amino or (1-6C)alkyl; phenyl or phenylamino, both optionally substituted with halogen, CN, (1-6C)alkyl, (1-6C)alkoxy or (di)[(1-6C)alkyl]amino; or (2-5C)heterocycloalkylamino; R3 is H; amino; halogen; hydroxy; cyano; (1-6C)alkyl; (2-6C)alkenyl; (2-6C)alkynyl; (di)[(1-4C)alkyl]amino; (1-4C)alkylcarbonylamino, the alkyl group of which optionally is substituted with halogen; or phenylalkyl, the phenyl group of which is optionally substituted with halogen; R4 is (1-4C)alkyl; halogen; or cyano; R5 and R6 are independently H or halogen; X is NHCO; CONH; N═C(CN); NHCH Y is CONH; NHCO; NHCONH; NHSO ar ring is an aryl ring selected from (2-5C)heteroaryl substituted with one or more groups selected from halogen, (1-6C)alkyl, phenyl, (2-5C)heterocycloalkyl, or (di)[(1-6C)alkyl]amino optionally substituted with (1-6C)alkoxy, OH, or (di)[(1-6C)alkyl]amino; or phenyl having Formula II wherein: R7 and R11 are independently H; halogen; (1-6C)alkyl; (di)[(1-6C)alkyl]amino; or amino; R8, R9 and R10 are independently H; halogen; amino; (1-6C)alkyl, optionally substituted with one or more CN, aminocarbonyl, halogen, hydroxy, phenyl or (2-5C)heterocycloalkyl; (1-6C)alkoxy, optionally substituted with one or more halogen, hydroxy or (1-6)alkoxy; (di)[(1-6C)alkyl]amino, optionally substituted with phenyl; (2-5C)heteroaryl; (2-5C)heterocycloalkyl, optionally substituted with cyano or (1-6C)alkyl; (di)[(1-6C)alkyl]amino); (1-6C)alkylcarbonyl: or phenylamino.