Patent ID: 8100970
Filing Date: 2012-01-24
Classification: A61L

Abstract:
1. A biological surgical patch comprising a natural animal tissue that has a substrate comprising collagen molecules, the substrate having: (i) been fixed with crosslinking reagents, (ii) specific active groups in protein molecules of the substrate that have been blocked by at least one active reagent after fixation by the crosslinking reagents, (iii) specific conformation of protein molecules of the substrate altered by a reagent with a guanidine compound, (iv) preformed polymers have been grafted into the collagen molecules by polycondensative primers wherein the polymers are polyglycolic acid (PGA) with glycolide as the polycondensative primers or the polymers are polylactic acid (PLA) with lactide as the polycondensative primers, and (v) an active layer coupled to the surface of the substrate, the active layer including either a polypeptide or a glucosaminoglycan that has the ability to adhere growth factors after implantation.