Patent ID: 8299306
Filing Date: 2012-10-30
Classification: C07C

Abstract:
1. A process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C or a salt thereof, comprising the following steps: a) forming a reaction mixture by adding to a suspension of Mg a compound of formula (II) wherein n is 1 or 2; R b) reacting the reaction mixture with a compound of formula (III) in a solvent to form a Grignard reagent, c) reacting the Grignard reagent with a linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C and then further reacting the compound of formula (IV) to obtain a compound of formula (I) by reducing the ester to the corresponding methyl alcohol and (i) debenzylating the protected alcohol when R is hydrogen or (ii) debenzylating the protected alcohol and then carrying out phenolic monoacylation when R is C