Patent ID: 6780873
Filing Date: 2004-08-24
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I): whereinbonds represented by the dashed lines are absent; R1 is -alkyl-NR3â€”CYâ€”NR5â€”Xâ€”R4 or -alkenyl-NR3â€”CYâ€”NR5â€”Xâ€”R4 wherein Y is &boxH;O; X is a bond, or â€”COâ€”; R4 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, each of which may be unsubstituted or substituted by one or more substituents selected from the group consisting of: -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -substituted aryl; -substituted heteroaryl; -substituted heterocyclyl; â€”O-alkyl; â€”O-(alkyl)0-1-aryl; â€”O-(alkyl)0-1-substituted aryl; â€”O-(alkyl)0-1-heteroaryl; â€”O-(alkyl)0-1-substituted heteroaryl; â€”O-(alkyl)0-1-heterocyclyl; â€”O-(alkyl)0-1-substituted heterocyclyl; â€”COOH; â€”COâ€”O-alkyl; â€”CO-alkyl; â€”S(O)0-2-alkyl; â€”S(O)0-2-(alkyl)0-1-aryl; â€”S(O)0-2-(alkyl)0-1-substituted aryl; â€”S(O)0-2-(alkyl)0-1-heteroaryl; â€”S(O)0-2-(alkyl)0-1-substituted heteroaryl; â€”S(O)0-2-(alkyl)0-1-heterocyclyl; â€”S(O)0-2-(alkyl)0-1-substituted heterocyclyl; -(alkyl)0-1-NR3R3; -(alkyl)0-1-NR3â€”COâ€”O-alkyl; -(alkyl)0-1-NR3â€”CO-alkyl; -(alkyl)0-1-NR3â€”CO-aryl; -(alkyl)0-1-NR3â€”CO-substituted aryl; -(alkyl)0-1-NR3â€”CO-heteroaryl; -(alkyl)0-1-NR3â€”CO-substituted heteroaryl; â€”N3; -halogen; -haloalkyl; -haloalkoxy; â€”CO-haloalkoxy; â€”NO2; â€”CN; â€”OH; â€”SH; and, in the case of alkyl, alkenyl or heterocyclyl, oxo; with the proviso that when X is a bond R4 can additionally be hydrogen; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -alkyl-O-alkyl; -alkyl-O-alkenyl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R3)2; â€”COâ€”N(R3)2; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -heterocyclyl; -substituted heterocyclyl; â€”CO-aryl; â€”CO-(substituted aryl); â€”CO-heteroaryl; and â€”CO-(substituted heteroaryl); each R3 is independently selected from the group consisting of hydrogen and C1-10 alkyl; R5 is selected from the group consisting of hydrogen and C1-10 alkyl, or R4 and R5 can combine to form a 3 to 7 membered heterocyclic or substituted heterocyclic ring; n is 0 to 4 and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, halogen and trifluoromethyl, or a pharmaceutically acceptable salt thereof.