Patent ID: 6166005
Filing Date: 2000-12-26
Classification: A61P,C07D,Y02P

Abstract:
A compound having a structure according to Formula (I) ##STR25## wherein R.sub.1 is H;R.sub.2 is hydrogen, alkyl or acyl;Ar is COR.sub.3 or SO.sub.2 R.sub.4 ; andR.sub.3 Is alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino or alkylarylamino;R.sub.4 is alkyl, heteroalkyl, aryl, or heteroaryl, substituted or unsubstituted;X is O, S, SO, or SO.sub.2 ; andR.sub.6 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino or alkylarylamino;R.sub.7 is hydrogen, alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino or alkylarylamino;R.sub.8 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino or alkylarylamino;R.sub.9 is alkyl, aryl, heteroaryl or heteroalkyl;W is hydrogen or one or more lower alkyl moieties, or is an alkylene, arylene, or heteroarylene bridge between two adjacent or nonadjacent carbons (thus forming a fused ring);Y is independently one or more of hydrogen, hydroxy, SR.sub.10, SOR.sub.4, SO.sub.2 R.sub.4, alkoxy, or amino, wherein amino is of formula NR.sub.11,R.sub.12, wherein R.sub.11 and R.sub.12 are independently chosen from hydrogen, alkyl, heteroalkyl, heteroaryl, aryl, SO.sub.2 R.sub.6, COR.sub.7, CSR.sub.8, and PO(R.sub.9).sub.2 ; andR.sub.10 is hydrogen, alkyl, aryl, heteroaryl;Z is nil, a spiro moiety or an oxo group substituted on the heterocyclic ring;n is 1;or an optical isomer, diastereomer or enantiomer for Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.