Patent ID: 6426428
Filing Date: 2002-07-30
Classification: A61K,A61Q

Abstract:
A process for the preparation of a benzalmalonate silane having the structural formula (I): in which R1, R2 and R3, which may be identical or different, are each an optionally halogenated C1-C10 alkyl radical or a phenyl radical; R4 and R5, which may be identical or different, are each a hydrogen atom, a hydroxyl group, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, or a trimethylsilyloxy radical; R6 and R7, which may be identical or different, are each a C1-C8 alkyl radical; a is 1; and Y is a divalent radical having one of the following formulae (1) to (4): wherein R8 is a hydrogen atom or a C1-C5 alkyl radical, and p is an integer ranging from 1 to 10, inclusive, with the proviso that the group â€”Yâ€”(O)aâ€” and the two radicals R4 and R5 are variously bonded to the aromatic ring member in the para-position and in the two meta-positions with respect to the radical â€”CH&boxH;Câ€”[(CO2R6)](CO2R7);said process comprising reacting an aromatic hydroxybenzaldehyde having the structural formula (8): with a halogenated silane having the formula (9):Halâ€”Yâ€”SiR1R2R3â€ƒâ€ƒ(9) in which Hal is a halogen atom, and then condensing the benzaldehyde thus obtained with a malonic diester having the structural formula (11):