Patent ID: 8394969
Filing Date: 2013-03-12
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein: X is absent or selected from: wherein each CH hydroxy, halogen, NH Y is selected from: wherein cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from R Z is selected from: wherein each CH each R wherein each CH wherein alkyl, alkenyl and alkynyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from: halogen, CF provided that at least one of and only one of R halogen, —CN, —CF R R each R wherein each CH each R wherein each CH each R wherein each CH each R wherein alkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: —OH, oxo, halogen, C each R wherein alkyl and cycloalkyl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: —OH, oxo, halogen, C each R wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, —OH, —CN, —NH n is 0, 1, 2, 3 or 4; m is 0, 1, 2, 3 or 4; p is 0, 1, 2, or 3; q is 0, 1, 2, 3 or 4; and r is 0, 1 or 2.