Patent ID: 7998933
Filing Date: 2011-08-16
Classification: A61K,A61P,A61Q,C07K

Abstract:
1. A cosmetic process for treating skin that has at least one sign of ageing, comprising applying to the skin at least one composition comprising, in a physiologically acceptable medium, at least one compound chosen from compounds of formula (I): wherein: Y is chosen from O and S, R optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH 2 ; —NHR; —NRR′; —NH—COR; -Hal (halogen); —CN; —COOR; —COR; —P(O)—(OR) 2 ; and —SO 2 —OR; wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; and (iii) radicals chosen from —OR; —NH wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; R optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH 2 ; —NHR; —NRR′; —NH—COR; -Hal (halogen); —CN; —COOR; and —COR; wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; R wherein: y is an integer ranging from 0 to 5 and y′ is an integer ranging from 1 to 5; A is chosen from linear and branched, saturated and unsaturated divalent hydrocarbon-based radicals containing from 1 to 18 carbon atoms, optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH 2 ; —NHR; —NRR′; —NH—COR; -Hal (halogen); —CN; —COOR; —COR; —NO 2 ; and —SO 2 —OR; wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; B, which may be identical or different, is chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH 2 ; —NHR; —NRR′; —NH—COR; -Hal (halogen, or even perhalogen); —CN; —COOR; —COR; —NO 2 ; and —SO 2 —OR; wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; X is a radical chosen from —OH, —OR wherein R 4 and R 5 , which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH 2 ; —NHR; —NRR′; —NH—COR; -Hal (halogen); —CN; —COOR; and —COR; wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; R 4 and R 5 optionally forming, together with N in the —NR 4 R 5 , a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH 2 ; —NHR″; —NH—COR″; -Hal (halogen); —CN; —COOR″; and —COR″; wherein R″ is chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen; the mineral acid and organic acid salts thereof, and the optical isomers thereof, in isolated form and as a racemic mixture, with the exception of the following compounds: N-acetylglycyl-N-(benzyl)-DL-valylglycine tert-butyl ester; N-acetylglycyl-N-(2-nitrobenzyl)-DL-valylglycine tert-butyl ester; and N-acetylglycyl-N-(2,4-dimethyloxybenzyl)-DL-valylglycine tert-butyl ester.