Patent ID: 6891047
Filing Date: 2005-05-10
Classification: A61P,C07D

Abstract:
1. A process for the preparation of atorvastatin in an amorphous form, which comprises: a) providing a solution of atorvastatin in one or more solvents of a first type such that atorvastatin is freely soluble; b) providing a mixture of said atorvastatin solution with one or more solvents of a second type, in which atorvastatin is insoluble or very slightly soluble, such that atorvastatin precipitates; c) separating the precipitate formed in step (b) from the mixture of solvents; wherein the solvent of the first type is a chlorinated solvent selected from the group consisting of chloroform and methylene chloride, a polar solvent selected from the group consisting of dimethyl formamide and dimethyl sulfoxide, or a mixture thereof and wherein the solvent of the second type comprises at least one solvent selected from the group consisting of ether solvents and aliphatic solvents.