Patent ID: 7432375
Filing Date: 2008-10-07
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 is an optionally substituted carbocyclyl, R 2 is an optionally substituted five membered heterocyclyl group, E is hydrogen, halogen, cyano, C 1-6 alkoxy or C 1-6 alkyl, G is hydrogen, halogen, cyano, C 1-6 alkoxy or C 1-6 alkyl, and L is hydrogen, halogen, cyano, C 1-6 alkoxy or C 1-6 alkyl; wherein R 1 is optionally fused to a partially saturated, unsaturated or fully saturated five to seven membered ring containing zero heteroatoms, and each substitutable carbon atom in R 1 , including the optional fused ring, is optionally and independently substituted by one or more of halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, haloalkyl, carbocyclyl, heterocyclyl, (CH 2 ) n OR 3 , (CH 2 ) n NR 3 2 , OR 3 , SR 3 , NO 2 , CN, NR 3 2 , NR 3 COR 3 , NR 3 CONR 3 2 , NR 3 COR 3 , NR 3 CO 2 R 3 , CO 2 R 3 , COR 3 , CONR 3 2 , S(O) 2 R 3 , SONR 3 2 , S(O)R 3 , SO 2 NR 3 2 , or NR 3 S(O) 2 R 3 wherein the C 1-12 alkyl group optionally contains one or more insertions selected from —O—, —N(R 3 )— —S—, —S(O)— and —S(O 2 )—; and each saturated carbon in the optional fused ring is further optionally and independently substituted by ═O, ═S, NNR 4 2 , ═N—OR 4 , ═NNR 4 COR 4 , ═NNR 4 CO 2 R 4 , ═NNSO 2 R 4 , or ═NR 4 ; and each substitutable nitrogen atom in R 1 is optionally substituted by R 5 , COR 5 , SO 2 R 5 or CO 2 R 5 ; wherein n is 1 to 6; wherein R 3 is hydrogen, C 1-12 alkyl, carbocyclyl or heterocyclyl, optionally substituted by one or more of C 1-6 alkyl, carbocyclyl, heterocyclyl, halogen, C 1-6 haloalkyl, OR 6 , SR 6 , NO 2 , CN, NR 6 R 6 , NR 6 COR 6 , NR 6 CONR 6 R 6 , NR 6 COR 6 , NR 6 CO 2 R 6 , CO 2 R 6 , COR 6 , CONR 6 2 , S(O) 2 R 6 , SONR 6 2 , S(O)R 6 , SO 2 NR 6 R 6 , NR 6 S(O) 2 R 6 , wherein the C 1-12 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 6 )—, —S(O)— and —S(O 2 )—, wherein each R 6 may be the same or different and is as defined below; wherein two R 3 in NR 3 2 may optionally form a partially saturated, unsaturated or fully saturated five to seven membered ring containing one to three heteroatoms, optionally and independently substituted by one or more of C 1-6 alkyl, halogen, C 1-6 haloalkyl, OR 6 , SR 6 , NO 2 , CN, NR 6 R 6 , NR 6 COR 6 , NR 6 CONR 6 R 6 , NR 6 COR 6 , NR 6 CO 2 R 6 , CO 2 R 6 , COR 6 , CONR 6 2 , S(O) 2 R 6 , SONR 6 2 , S(O)R 6 , SO 2 NR 6 R 6 , NR 6 S(O) 2 R 6 , wherein the C 1-6 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 6 )—, —S(O)— and —S(O 2 )—, wherein each R 6 may be the same or different and is as defined below; wherein R 4 is hydrogen, C 1-12 alkyl, carbocyclyl or heterocyclyl, optionally substituted by one or more of C 1-6 alkyl, halogen, C 1-6 haloalkyl, OR 6 , SR 6 , NO 2 , CN, NR 6 R 6 , NR 6 COR 6 , NR 6 CONR 6 R 6 , NR 6 COR 6 , NR 6 CO 2 R 6 , CO 2 R 6 , COR 6 , CONR 6 2 , S(O) 2 R 6 , S(O)R 6 , SO 2 NR 6 R 6 , NR 6 S(O) 2 R 6 , wherein the C 1-12 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 6 )—, —S(O)— and —S(O 2 )—, wherein each R 6 may be the same or different and is as defined below; wherein R 5 is hydrogen, C 6-12 aryl, C 1-6 alkyl or C 1-6 haloalkyl; wherein R 6 is hydrogen, C 1-6 alkyl, or C 1-6 haloalkyl; and wherein R 2 is a five-membered heterocyclyl group containing from 1 to 4 heteroatoms independently selected from N, S or O, wherein at least one heteroatom is N and wherein the optionally substituted five-membered heterocyclyl group is optionally fused to a partially saturated, unsaturated or fully saturated five to seven membered ring containing zero to three heteroatoms, and each substitutable carbon or heteroatom in R 2 including the optional fused ring, is optionally and independently substituted by one or more of halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, haloalkyl, carbocyclyl, heterocyclyl, (CH 2 ) n OR 7 , (CH 2 ) n NR 7 2 , OR 7 , SR 7 , NO 2 , CN, NR 7 2 , NR 7 COR 7 , NR 7 CONR 7 2 , NR 7 COR 7 , NR 7 CO 2 R 7 , CO 2 R 7 , COR 7 , CONR 7 2 , S(O) 2 R 7 , SONR 7 2 , S(O)R 7 , SO 2 NR 7 2 , or NR 7 S(O) 2 R 7 wherein the C 1-12 alkyl group optionally contains one or more insertions selected from —O—, —N(R 7 )— —S—, —S(O)— and —S(O 2 )—; and each saturated carbon in the optional fused ring is further optionally and independently substituted by ═O, ═S, NNR 8 2 , ═N—OR 8 , ═NNR 8 COR 8 , ═NNR 8 CO 2 R 8 , ═NNSO 2 R 8 , or ═NR 8 ; and each substitutable nitrogen atom in R 2 is optionally substituted by R 9 , COR 9 , SO 2 R 9 or CO 2 R 9 ; wherein n is 1 to 6; wherein R 10 is hydrogen, C 1-6 alkyl, or C 1-6 haloalkyl; wherein R 7 is hydrogen, C 1-12 alkyl, carbocyclyl or heterocyclyl, optionally substituted by one or more of C 1-6 alkyl, carbocyclyl, heterocyclyl, halogen, C 1-6 haloalkyl, OR 11 , SR 11 , NO 2 , CN, NR 11 R 11 , NR 11 COR 11 , NR 11 CONR 11 R 11 , NR 11 COR 11 , NR 11 CO 2 R 11 , CO 2 R 11 , COR 11 , CONR 11 2 , S(O) 2 R 11 , SONR 11 2 , S(O)R 11 , SO 2 NR 11 R 11 , NR 11 S(O) 2 R 11 , wherein the C 1-12 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 11 )—, —S(O)— and —S(O 2 )—, wherein each R 11 may be the same or different and is as defined below; wherein two R 7 in NR 7 2 may optionally form a partially saturated, unsaturated or fully saturated five to seven membered ring containing one to three heteroatoms, optionally and independently substituted by one or more of C 1-6 alkyl, halogen, C 1-6 haloalkyl, OR 11 , SR 11 , NO 2 , CN, NR 11 R 11 , NR 11 COR 11 , NR 11 CONR 11 R 11 , NR 11 COR 11 , NR 11 CO 2 R 11 , CO 2 R 11 , COR 11 , CONR 11 2 , S(O) 2 R 11 , SONR 11 2 , S(O)R 11 , SO 2 NR 11 R 11 , NR 11 S(O) 2 R 11 , wherein the C 1-6 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 11 )—, —S(O)— and —S(O 2 )—, wherein each R 11 may be the same or different and is as defined below; wherein R 8 is hydrogen, C 1-12 alkyl, carbocyclyl or heterocyclyl, optionally substituted by one or more of C 1-6 alkyl, halogen, C 1-6 haloalkyl, OR 11 , SR 11 , NO 2 , CN, NR 11 R 11 , NR 11 COR 11 , NR 11 CONR 11 R 11 , NR 11 COR 11 , NR 11 CO 2 R 11 , CO 2 R 11 , COR 11 , CONR 11 2 , S(O) 2 R 11 , S(O)R 11 , SO 2 NR 11 R 11 , NR 11 S(O) 2 R 11 , wherein the C 1-12 alkyl group optionally incorporates one or two insertions selected from the group consisting of —O—, —N(R 11 )—, —S(O)— and —S(O 2 )—, wherein each R 11 may be the same or different and is as defined below; wherein R 9 is hydrogen, C 6-12 aryl, C 1-6 alkyl or C 1-6 haloalkyl; and wherein R 11 is hydrogen, C 1-6 alkyl, or C 1-6 haloalkyl.