Patent ID: 6020507
Filing Date: 2000-02-01
Classification: C07D,Y02P

Abstract:
A process for preparing paclitaxel by converting baccatin III into 7-O-acyl-protected baccatin III in good yield and high quality with an electrophilic protecting group of the formula ##STR11## wherein R is alkyl, aryl, R'O--, or R'.sub.2 N--, R'S, and X is halogen, imidazoyl, benztriazole, N-(benzyloxycarboxyloxy) succinimide, OR', or --OOCOR, with a strong base in a solvent of the general formula, R--CONR'.sub.2, and wherein R' is alkyl or alkenyl having 1-6 carbon atoms, benzyl, phenyl, trichloroethyl, trifluoroethyl, 2-trimethylsilylethyl or triisopropylsilyl.