Patent ID: 6630589
Filing Date: 2003-10-07
Classification: A61K,C07D,C12Q,G01N

Abstract:
A compound having the formula: or a pharmaceutically acceptable salt thereof, where V, Y, and Z are independently N, CH, or C; B is N, CH, or CR4, where R4 is F or lower alkyl; X is independently H, Hal, lower alkyl, OR5, SR6, or NR7R8, where R5, R6, R7, and R8 are independently H or lower alkyl, and n is 1, 2, 3, or 4; R1 and R2 together are (CR9R10)m, where R9 and R10 are independently H, lower alkyl, CH2OR11, (CH2)oNR12R13, or OR14, where R11, R12, R13, and R14 are independently H, lower alkyl, aryl, or alkaryl, m is 2, 3, 4, or 5, and o is 0 or 1; and R3 is H, lower alkyl, F, OR15, where R15 is H, lower alkyl, or aralkyl, or a substituent of the structure: where R16 is NH, O, or S; R17 is H, lower alkyl, or aralkyl; and W is lower alkyl, lower alkenyl, lower alkynyl, aryl, heteroaryl, alkaryl, OR18, or NR19R20, where R18, R19, and R20 are independently H, lower alkyl, lower alkenyl, lower alkynyl, aryl, alkaryl, aralkyl, or (CH2)kCH2OR21, where R21 is H or lower alkyl, and k is 1,2, 3, or 4, provided that when Xn is H, V, Y, and Z are C or CH, R1 and R2 together are (CH2)4, B is CR4, and R4 is F, R3 is not F or H; when Xn is H, V, Y, and Z are C or CH, R1 and R2 together are (CH2)4, B is CR4, and R4 is Me, R3 is not H; when Xn is H, V, Y, and Z are C or CH, R1 and R2 together are (CH2)4, B is CR4, and R4 is H, R3 is not H or F; when Xn is H, V, Y, and Z are C or CH, R1 and R2 together are (CH2)4, B is CH, W is methyl, and R16 is O, R17 is not H; when Xn is H, V, Y, and Z are C or CH, B is CH, and R1 and R2 together are (CH2)5, R3 is not methoxy; when Xn is H, V, Y, and Z are C or CH, B is CH, and R1 and R2 together are (CH2)5, R3 is not F; and Xn is H, V, Y, and Z are C or CH, B is CH, and R1 and R2 together are (CH2)5, R3 is not ethoxy.