Patent ID: 6441141
Filing Date: 2002-08-27
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method of producing antibodies comprising:1)immunizing an animal with an immunogenic composition comprising a synthetic peptide comprising an amino acid sequence corresponding to the carboxy terminal regions of an E fragment arising as a result of plasmin cleavage of fibrin and fibrinogen, 2) isolating antibodies raised against said peptide, and 3) purifying or immunoabsorbing said antibodies, wherein the amino acid sequence corresponding to the carboxy terminal regions of an E fragment arising as a result of plasmin cleavage of fibrin and fibrinogen is selected from the group consisting of:a) Leu-Phe-Glu-Tyr-Gln-Lys-OH, (SEQ ID NO:1), b) Tyr-Met-Tyr-Leu-Leu-Lys-OH, (SEQ ID NO:2), c) Val-Lys-Glu-Leu-Ile-Lys-OH, (SEQ ID NO:3), and d) His-Gln-Val-Glu-Asn-Lys-OH (SEQ ID NO:4).