Patent ID: 8975245
Filing Date: 2015-03-10
Classification: A61K,A61P,B82Y

Abstract:
1. A formulation comprising a neuroactive steroid anaesthetic formulated with a cyclodextrin, wherein the neuroactive steroid anaesthetic is selected from the group consisting of alphadolone, allopregnanolone, ganaxolone, pregnanolone, acebrochol, hydroxydione, minaxolone and tetrahydroxy corticosterone, or a deuterated, tritiated or labelled derivative or salt thereof, and wherein the cyclodextrin is (7) sulfobutyl ether β-cyclodextrin or an alkyl ether derivative thereof and wherein the molar ratio of neuroactive steroid anaesthetic to cyclodextrin is from 1:1.6 to 1:2.5 except for alphadolone where the complexation ratio is from 1:2 to 1:2.5.