Patent ID: 7514442
Filing Date: 2009-04-07
Classification: A61P,C07D

Abstract:
1. A method of treating chronic lymphocytic leukemia (CLL) by inhibiting a cyclin dependent kinase in a patient, comprising administering a therapeutically effective amount of at least one compound represented by the structural formula I: wherein: R is an unsubstituted aryl or aryl substituted with one or more moieties which moieties can be the same or different, each moiety being independently selected from the group consisting of halogen, CN, —OR R R  wherein each of said alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl and heteroarylalkyl for R R R R R R R R m is 0 to 4, and n is 1 to 4, with the following provisos: (i) that when N is an unsubstituted phenyl, then R 2 is not alkyl(C 2 -C 6 ), —C(O) 2 R 6 , aryl or cycloalkyl, and (ii) that when R is a phenyl substituted with a hydroxyl group, then R 2 is halogen only, or a pharmaceutically acceptable salt thereof, to said patient, wherein said cyclin dependent kinase is CDK1 or CDK2.