Patent ID: 6143932
Filing Date: 2000-11-07
Classification: C07K,C40B

Abstract:
A single compound of the Formula (I): ##STR18## wherein: R.sub.1 and R.sub.2 independently are a hydrogen atom, an amino protecting group, C.sub.1 to C.sub.12 acyl, C.sub.3 to C.sub.10 cycloalkyl, C.sub.3 to C.sub.6 heterocycle, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 substituted alkyl, C.sub.7 to C.sub.16 alkylaryl, C.sub.7 to C.sub.16 substitued alkylaryl, a C.sub.6 to C.sub.15 alkyl heterocycle, or a substituted C.sub.6 to C.sub.15 alkyl heterocycle;R.sub.3, R.sub.5, and R.sub.7 are independently a hydrogen atom, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 substituted alkyl, phenyl, substituted phenyl, C.sub.7 to C.sub.16 alkylaryl, C.sub.7 to C.sub.16 substitued alkylaryl, a C.sub.6 to C.sub.15 alkyl heterocycle, or a substituted C.sub.6 to C.sub.15 alkyl heterocycle;R.sub.4, R.sub.6, and R.sub.8 are independently a C.sub.1 to C.sub.18 substituent group; with the proviso that all but one of R.sub.4, R.sub.6 and R.sub.8 can simultaneously be the same group;R.sub.9 is a hydrogen atom or a solid support;R.sub.10 is optionally present as a C.sub.1 to C.sub.18 substituent group when R.sub.1 and R.sub.2 are other than a hydrogen atom or an amino protecting group;AA, BB, and CC are independently 0 to 5;B is from 0 to 3;further wherein the stereochemistry at the carbons bonded to R.sub.3, R.sub.5, and R.sub.7 are independently R or S or a mixture of the two;further wherein, when B is 2 or 3, each R.sub.4 and R.sub.5 can be the same or different;further wherein, when B is 0, each R.sub.6 and R.sub.8 is different;with the proviso that either R.sub.1 or R.sub.2 can be taken with R.sub.3 ; R.sub.4 can be taken with R.sub.5 ; R.sub.6 can be taken with R.sub.7 ; respectively and independently, to form a subtituted or unsubstituted pyrrolidine ring;X and Y are either 1) each a hydrogen atom or 2) taken together to represent a carbonyl group;and a pharmaceutically acceptable salt, solvate or hydrate thereof.