Patent ID: 9062123
Filing Date: 2015-06-23
Classification: A61K,C07K

Abstract:
1. A method of determining the presence and density of adrenomedullin receptor-bearing cells in a mammal comprising: administering to the mammal an effective amount of labelled adrenomedullin derivative to achieve binding between the labelled adrenomedullin derivative and adrenomedullin-receptor-bearing cells; and imaging the mammal to determine distribution of the labelled adrenomedullin derivative; the labelled adrenomedullin derivative comprising an adrenomedullin fragment having the sequence: X1-X2-X3-X4-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr (SEQ ID NO:3), wherein: