Patent ID: 8975416
Filing Date: 2015-03-10
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method of treating Clostridium difficile -associated disease (CDAD) in a subject in need thereof, the CDAD selected from the group consisting of diarrhoea caused by Clostridium difficile , bloating caused by Clostridium difficile , flu-like symptoms caused by Clostridium difficile , fever caused by Clostridium difficile , appetite loss caused by Clostridium difficile , abdominal pain caused by Clostridium difficile , nausea caused by Clostridium difficile , dehydration caused by Clostridium difficile , colitis caused by Clostridium difficile and pseudomembraneous colitis caused by Clostridium difficile , which method comprises a) detecting infection and/or intoxication of the subject with one or more strains of b) administering to the subject an effective amount of a compound of formula (I): wherein: L1 is a direct bond or a linker group; R each R X X X R or a pharmaceutically acceptable N-oxide, salt, hydrate, solvate; and c) preventing or reducing the rate of bacterial growth, and/or mediating the cellular destruction of bacterial cells, of the one or more strains of