Patent ID: 7687462
Filing Date: 2010-03-30
Classification: A61F,A61K,A61P

Abstract:
1. A method of increasing cartilage formation or repair comprising: applying a NELL-1 peptide or an expression vector encoding said NELL-1 peptide in an effective amount for cartilage formation or repair in a region where cartilage formation or repair is desired; optionally applying an agent to the region where cartilage formation or repair is desired; and at least inducing hypertrophy of chondroblast in the region where cartilage formation or repair is desired, wherein the NELL-1 peptide comprises the amino acid sequence set forth in SEQ ID NO: 2, 4, or 6 or a fragment of the amino acid sequence of SEQ ID NO: 2, 4, or 6 which has cartilage-forming activity.