Patent ID: 8084021
Filing Date: 2011-12-27
Classification: A61K,A61P,C07H,C07K,Y02A

Abstract:
1. A human serum albumin-interleukin-11 (HSA-IL-11) fusion protein comprising: (a) the amino acid sequence set forth in SEQ ID NO: 2; (b) the amino acid sequence encoded by the polynucleotide set forth in SEQ ID NO: 1; or (c) the amino acid sequence encoded by the polynucleotide contained in the yeast strain designated as YZ-HSA/IL-11 in ATCC® Deposit No: PTA-4607, said HSA-IL-11 fusion protein having a plasma half-life longer than a plasma half-life of interleukin-11, and said HSA-IL-11 fusion protein being a human serum albumin-human interleukin-11 fusion protein, wherein the human interleukin-11 is linked directly to the C-terminus of the human serum albumin without a peptide linker, and said HSA-IL-11 fusion protein has a shelf-life four times or longer than a shelf-life of the interleukin-11.