Patent ID: 6794381
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
A compound of Formula (I): or a pharmaceutically acceptable salt or prodrug thereof, wherein:A is O; Q is â€”NR1R2; R1, at each occurrence, is independently selected from: H; C1-C6 alkyl substituted with 0-3 R1a; C2-C6 alkenyl substituted with 0-3 R1a; C3-C10 carbocycle substituted with 0-3 R1b; C6-C10 aryl substituted with 0-3 R1b; and 5 to 10 membered heterocycle substituted with 0-3 R1b; R1a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3; C3-C10 carbocycle substituted with 0-3 R1b; C6-C10 aryl substituted with 0-3 R1b; and 5 to 6 membered heterocycle substituted with 0-3 R1b; R1b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy; R2 is H or C1-C6 alkyl; R3 is â€”(CR7R7a)nâ€”R4, â€”(CR7R7a)nâ€”Sâ€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”Oâ€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”N(R7b)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”S(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”S(&boxH;O)2â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”C(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”N(R7b)C(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”C(&boxH;O)N(R7b)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”N(R7b)S(&boxH;O)2â€”(CR7R7a)mâ€”R4, or â€”(CR7R7a)nâ€”S(&boxH;O)2N(R7b)â€”(CR7R7a)mâ€”R4; n is 0, 1, 2, or 3; m is 0, 1, 2, or 3; R3a is H, OH, C1-C4 alkyl, C1-C4 alkoxy, or C2-C4 alkenyloxy; R4 is H, OH, OR14a, C1-C6 alkyl substituted with 0-3 R4a, C2-C6 alkenyl substituted with 0-3 R4a, C2-C6 alkynyl substituted with 0-3 R4a, C3-C10 carbocycle substituted with 0-3 R4b, C6-C10 aryl substituted with 0-3 R4b, or 5 to 10 membered heterocycle substituted with 0-3 R4b; R4a, at each occurrence, is independently selected from is H, F, Cl, Br, I, CF3, C3-C10 carbocycle substituted with 0-3 R4b, C6-C10 aryl substituted with 0-3 R4b, or 5 to 10 membered heterocycle substituted with 0-3 R4b; R4b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; R5 is H, OR14; C1-C6 alkyl substituted with 0-3 R5b; C1-C6 alkoxy substituted with 0-3 R5b; C2-C6 alkenyl substituted with 0-3 R5b; C2-C6 alkynyl substituted with 0-3 R5b; C3-C10 carbocycle substituted with 0-3 R5c; C6-C10 aryl substituted with 0-3 R5c; or 5 to 10 membered heterocycle substituted with 0-3R5c; R5a is H, OH, C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, or C2-C4 alkenyloxy; R5b, at each occurrence, is independently selected from: H, C1-C6 alkyl, CF3, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16; C3-C10 carbocycle substituted with 0-3 R5c; C6-C10 aryl substituted with 0-3 R5c; or 5 to 10 membered heterocycle substituted with 0-3 R5c; R5c, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; R6 is H; C1-C6 alkyl substituted with 0-3 R6a; C3-C10 carbocycle substituted with 0-3 R6b; or C6-C10 aryl substituted with 0-3R6b; R6a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, phenyl or CF3; R6b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy; R7, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, CF3, and C1-C4 alkyl; R7a, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, CF3, aryl and C1-C4 alkyl; R7b is independently selected from H and C1-C4 alkyl; W is â€”(CR8R8a)pâ€”; p is 0, 1, 2, 3, or 4; R8 and R8a, at each occurrence, are independently selected from H, F, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl and C3-C8 cycloalkyl; X is a bond; C6-C10 aryl substituted with 0-3 RXb; C3-C10 carbocycle substituted with 0-3 RXb; or 5 to 10 membered heterocycle substituted with 0-2 RXb; RXb, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; Y is a bond or â€”(CR9R9a)tâ€”Vâ€”(CR9R9a)uâ€”; t is 0, 1, 2, or 3; u is 0, 1, 2, or 3; R9 and R9a, at each occurrence, are independently selected from H, F, C1-C6 alkyl or C3-C8 cycloalkyl; V is a bond, â€”C(&boxH;O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”N(R19)â€”, â€”C(&boxH;O)NR19bâ€”, NR19bC(&boxH;O)â€”, â€”NR19bS(&boxH;O)2â€”, â€”S(&boxH;O)2NR19bâ€”, â€”NR19bS(&boxH;O)â€”, â€”S(&boxH;O)NR19bâ€”, â€”C(&boxH;O)Oâ€”, or â€”OC(&boxH;O)â€”; Z is C1-C3 alkyl substituted with 1-2 R12; C6-C10 aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle substituted with 0-3 R12b; R12 is C6-C10 aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle substituted with 0-3 R12b; R12b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; B is a seven membered lactam, wherein the lactam is saturated, partially saturated or unsaturated; and wherein each additional lactam carbon is substituted with 0-2 R11; R11, at each occurrence, is independently selected from C1-C4 alkoxy, Cl, F, Br, I, &boxH;O, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl substituted with 0-1 R11a; C6-C10 aryl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle substituted with 0-3 R11b; R11a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3, or phenyl substituted with 0-3 R11b; R11b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; R14, at each occurrence, is independently selected from H, phenyl, benzyl, C1-C6 alkyl, or C2-C6 alkoxyalkyl; R14a is H, phenyl, benzyl, or C1-C4 alkyl; R15, at each occurrence, is independently selected from H, C1-C6 alkyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); R16, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); R17 is H, aryl, arylâ€”CH2â€”, C1-C6 alkyl, or C2-C6 alkoxyalkyl; R18, at each occurrence, is independently selected from H, C1-C6 alkyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); and R19, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); and R19b is H, C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, benzyl or phenethyl.