Patent ID: 6395302
Filing Date: 2002-05-28
Classification: A61K,B82Y,Y10S

Abstract:
A method for preparing microspheres encapsulating colloidal systems, which method comprises the steps of:a) providing an aqueous mixture of i) a first phase comprising a first water soluble crosslinkable polymer, ii) a second phase comprising a second water soluble polymer which is incompatible in solution with the polymer in said first phase, and iii) colloidal systems to be suspended in said first phase; b) forming an emulsion of said first phase in said second phase; c) forming microspheres in the emulsion by crosslinking at least part of said crosslinkable polymer, thus forming said microspheres encapsulating colloidal systems; and d) recovering the microspheres; wherein said colloidal systems are selected from the group consisting of liposomes, iscoms, polyplexes, lipoplexes, nanoparticles, solid lipid particles in the colloidal size range, emulsions, and combinations thereof.