Patent ID: 6949562
Filing Date: 2005-09-27
Classification: A61P,C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof wherein: the b-ring is a 5-8 membered ring; E represents (CR G is oxgyen or NH; J represents (CR R R the group is the A ring and represents a saturated, partially unsaturated, or aromatic heterocyclic 6 membered ring containing one nitrogen atom, X is hydrogen, hydroxy, amino, mono- or di(C T is hydrogen, halogen, hydroxy, amino, mono- or di(C Q is a saturated carbocyclic or heterocyclic group, partially unsaturated carbocyclic or heterocyclic group, an aryl group, or heteroaryl group, where each group has from 1 to 3 rings where each ring contains from 3 to 8 ring members, and where each heterocyclic and heteroaryl group contains at least one ring having from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; and W is a bond, oxygen, NH, sulfur, —CH═CH—, —C≡C—, or CR Z is hydrogen, hydroxy, hydroxy(C Z is a saturated carbocyclic or heterocyclic group, a partially unsaturated carbocyclic or heterocyclic group, an aryl group, or a heteroaryl group, where each group has from 1 to 3 rings where each saturated ring contains from 3 to 8 ring members and each aromatic or partially unsaturated ring contains from 5-8 ring members, and where each heterocyclic and heteroaryl group contains at least one ring having from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; and where each carbocyclic, heterocyclic, aryl, and heteroaryl group is optionally substituted with 1, 2, or 3 groups independently selected from C and independently represent saturated carbon chains optionally substituted with one or more substituents independently selected from halogen, cyano, nitro, amino, mono- or di(C 1 -C 6 )alkylamino, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, C 1 -C 6 alkyl, and C 3 -C 7 cycloalkyl;