Patent ID: 6686474
Filing Date: 2004-02-03
Classification: A61P,C07D

Abstract:
A method for the production of an antiulcerative of formula I: whereinR1, R2 and R3 are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 fluoroalkyl and C1-C8 alkoxy, R4 and R5 are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, CH2â€”C3-C8 cycloalkyl, C1-C8 alkoxycarbonyl, C1-C8 alkoxy, C1-C8 fluoroalkoxy, CF3, C2-C8 fluoroalkyl and C(O)Oâ€”C1-C8 alkyl, and R6 is hydrogen or C1-C2 alkyl, wherein the method comprises reacting a compound of formula II: wherein R1, R2, R3, R4, R5 and R6 are defined as above, with m-chloroperoxybenzoic acid in a solvent selected from the group consisting of acetone and acetone/water mixture to form a reaction mixture, raising the pH of the reaction mixture to above pH 7.0, whereby crystals of the compound of formula I are formed, and separating the crystals of the compound of formula I.