Patent ID: 9085529
Filing Date: 2015-07-21
Classification: C07B,C07C,C07D

Abstract:
1. A process for preparing a compound of formula (2), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group —COOR, wherein R is C A) a) reacting a compound of formula (1), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group; with a transition metal catalyst, optionally in the presence of a base, to obtain the compound of formula (4), or salt thereof wherein R1 is hydrogen or a nitrogen protecting group; or A) b) i) reacting a compound of formula (3), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group; with a selenide in the presence of a base, to obtain a compound of formula (6), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group; and R is aryl; and A) b) ii) treating the compound of formula (6) with an oxidizing agent; to obtain the compound of formula (4) or a salt thereof, and B) reacting the obtained compound of formula (4) or a salt thereof with a lactam ring opening agent to obtain a compound of formula (5) with (Z) configuration or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R is hydrogen or a C C) reducing the obtained compound of formula (5), or a salt thereof, to obtain the compound of formula (2).