Patent ID: 7888091
Filing Date: 2011-02-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated fusion protein comprising a guanylate kinase moiety comprising SEQ ID NO. 49 and a thymidine kinase moiety, wherein said fusion protein possesses a biological activity of said guanylate kinase and a biological activity of said thymidine kinase, wherein said thymidine kinase moiety is either a Herpesviridae thymidine kinase of SEQ ID. NO. 134 or a mutant Herpesviridae thymidine kinase of SEQ ID. NO. 134 with an amino acid substitution at one or more of positions 160, 161 or 168 that possesses increased biological activity, when compared to the Herpesviridae thymidine kinase of SEQ ID. NO. 134.