Patent ID: 6232322
Filing Date: 2001-05-15
Classification: A61K,C07D

Abstract:
A compound of formula I having the structure ##STR18##whereinA is ##STR19##B is carbon;D is oxygen, sulfur, or nitrogen;E is carbon;Y is a bond, methylene, C(O), or CH(OH);R.sup.1 is alkyl having 1 to 12 carbons, aryl of 6-12 carbon atoms, arylalkyl of 7-15 carbon atoms, halogen, carboxaldehyde, trifluoromethyl, alkoxy of 1-6 carbon atoms, 2,2-dimethyl-1,3-benzodioxole, Het-alkyl wherein the alkyl moiety have 1-6 carbon atoms, or aryl of 6-10 carbon atoms which is mono-, di-, or tri-substituted with halogen, trifluormethyl, or alkoxy of 1-6 carbon atoms;Het is ##STR20##G is oxygen, sulfur or nitrogen;R.sup.2 and R.sup.2a are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, trifluoromethyl;R.sup.3 and R.sup.4 are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, trifluoromethyl, alkoxy of 1-6 carbon atoms, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfoamide, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, --NR.sup.7 (CH.sub.2).sub.m CO.sub.2 H, pyrrolidinone, a heterocycic ring having 5 to 7 atoms and having 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur, or aryl of 6-10 carbon atoms mono-, di-, or tri-substituted with trifluoromethyl, alkyl of 1-6 carbon atoms or, alkoxy of 1-6 carbon atoms;R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, --CH(R.sup.8)R.sup.9, --C(CH.sub.2).sub.n CO.sub.2 R.sup.10, --C(CH.sub.3).sub.2 CO.sub.2 R.sup.10, --CH(R.sup.8)(CH.sub.2).sub.n CO.sub.2 R.sup.10, --CH(R.sup.8)C.sub.6 H.sub.4 CO.sub.2 R.sup.10R.sup.6 is alkylene of 1 to 3 carbon atomsR.sup.7 is hydrogen or alkyl of 1 to 6 carbon atoms,R.sup.8 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, phthalic acid, or Q-alkyl wherein the alkyl moiety has 1-6 carbon atoms;Q is ##STR21##W is oxygen, sulfur, or nitrogen;R.sup.9 is --CO.sub.2 R.sup.12, --CONHR.sup.12, tetrazole, --PO.sub.3 R.sup.12 ;R.sup.10 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 7-15 carbon atoms, or aralkyl of 7-15 carbon atoms;R.sup.12 is hydrogen, alkyl, aryl of 6-12 carbon atoms, aralkyl of 7-15 carbon atoms;m=1-3;n=1-6;with the proviso that when R.sup.1 is halogen, Y is a bond;or a pharmaceutically acceptable salt thereof.