Patent ID: 6129932
Filing Date: 2000-10-10
Classification: A61K

Abstract:
A process for making a pharmaceutical composition comprising [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl-.beta.ala nine, which comprises the steps ofa) mixing, in a vessel suitable for granulation, an amount of about 25% by weight of the composition of [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl-.beta.-al anine with an amount of between about 30% and 35% by weight of the Composition of pre-gelatinized starch and with pharmaceutically acceptable amounts of pharmaceutically acceptable disintegrants and with pharmaceutically acceptable amounts of pharmaceutically fillers or diluents;b) adding a granulating fluid to the mixture during mixing of step a) to form granules;c) drying the granules to form dried granules;d) milling the dried granules to form milled granules;e) lubricating the milled granules to form lubricated granules; andf) compressing the lubricated granules into tablets.