Patent ID: 6719972
Filing Date: 2004-04-13
Classification: A61K,A61P,C07K

Abstract:
A method for inhibiting T cell proliferation or IL-2 accumulation by an activated T cell comprising contacting a population of cells comprising the activated T cell with an anti-CTLA4 monoclonal antibody or fragment thereof, which binds an epitope on a CTLA4 molecule which is distinct from a B7-1 or B7-2 binding site on CTLA4, said epitope comprising the amino acid sequence (Xaa)n-Leu-Thr-Phe-Leu-Asp-Asp-(Xaa)n (SEQ ID NO: 33), wherein Xaa is any amino acid and n=0-20, and wherein said anti-CTLA4 monoclonal antibody or fragment thereof stimulates a CTLA4-associated signal in the activated T cell such that T cell proliferation or IL-2 accumulation by the activated T cell is inhibited.