Patent ID: 8232379
Filing Date: 2012-07-31
Classification: A61K,A61P,C07K,C12N,C12Q,G01N,Y02A

Abstract:
1. An isolated nucleic acid comprising a transcriptional unit encoding a Japanese encephalitis virus (JEV) signal sequence and an immunogenic flavivirus antigen of a flavivirus other than JEV, wherein the immunogenic flavivirus antigen of a flavivirus other than JEV is selected from the group consisting of an M protein of a flavivirus, an E protein of a flavivirus, both an M protein and an E protein of a flavivirus, a portion of an M protein of a flavivirus, a portion of an E protein of a flavivirus and both a portion of an M protein of a flavivirus and a portion of an E protein of a flavivirus, or any combination thereof, and wherein the transcriptional unit directs the synthesis of the immunogenic flavivirus antigen.