Patent ID: 8530235
Filing Date: 2013-09-10
Classification: A61K,A61P,C12N

Abstract:
1. A medium that supports culture of an oocyte, comprising: (a) a growth factor component comprising: (i) follicle stimulating hormone (FSH); and (ii) at least one of Growth Differentiation Factor 9 (GDF-9), Bone Morphogenetic Protein 15 (BMP-15) and Bone Morphogenetic Protein 6 (BMP-6); and optionally (b) at least one of the following: (i) one or more denuded oocytes; (ii) oocyte-conditioned medium; (iii) one or more oocyte secreted factors; (iv) an agent that increases the activity of a GDF-9-dependent signalling pathway in one or more of an oocyte, a cumulus cell associated with an oocyte, and an embryo; (v) an agent that increases the activity of a BMP-15-dependent signalling pathway in one or more of an oocyte, a cumulus cell associated with an oocyte, and an embryo; and (vi) an agent that increases the activity of a BMP-6-dependent signalling pathway in one or more of an oocyte, a cumulus cell associated with an oocyte, and an embryo.