Patent ID: 6248546
Filing Date: 2001-06-19
Classification: G01N,Y10S

Abstract:
A kit for an assay of a native ternary complex of IGFBP-3 and IGF and ALS or a native binary complex of IGFBP-3 and ALS or IGF,said kit comprising a capture-antibody and a detection-antibody,wherein said antibodies do not bind to overlapping epitopes and do not effect dissociation of a native ternary complex of IGFBP-3 and IGF and ALS or a native binary complex of IGFBP-3 and ALS or IGF (collectively called the IGFBP-complex),and wherein one of said antibodies binds to IGFBP-3 in the IGFBP-complex and the other of said antibodies binds to IGF or ALS in the IGFBP-complex, thus allowing specific detection of the IGFBP-complex.