Patent ID: 7384939
Filing Date: 2008-06-10
Classification: C07D

Abstract:
1. A process for producing a carboxamide pyridine compound of the formula: said method comprising: (a) reacting a pyridinium salt of the formula:  with an α-cyano-β-aryl acrylate compound of the formula:  to produce a pyridinium zwitter ionic compound of the formula: (b) reacting the pyridinium zwitter ionic compound with a reagent selected from the group consisting of POCl (c) reacting the cyanopyridine compound of formula VIII with an amine compound of the formula HNR (d) hydrogenating the tetra-substituted pyridine compound formula IX in the presence of a hydrogenation catalyst to form a tri-substituted pyridine compound of the formula: and (e) hydrolyzing the tri-substituted pyridine compound to form the carboxamide compound of Formula I, wherein each R a is an integer from 0 to 2; R R or R or R R X X is halide.