Patent ID: 7576215
Filing Date: 2009-08-18
Classification: A61P,C07D

Abstract:
1. A compound of formula I having the structure: wherein: R X R R X R R W is a bond, —O—, —S—, —S(O)—, —S(O) Y is —CO—, —S(O) j is 0 to 3; k is 0 to 3; t is 0 to 2; D is a bond, —CH═CH—, —C≡C—, —C═, —C(O)—, phenyl, —O—, —NH—, —S—, —CHR p is 0 to 3; Z is —CO A is phenyl, naphthyl, tetrahydronaphthyl, indan or biphenyl, each of which may be optionally substituted by one to four groups independently selected from halogen, C A is a heterocycle selected from pyrrole, pyridine, pyridine-N-oxide, pyrimidine, pyrazole, thiophene, furan, quinoline, oxazole, thiazole, imidazole, isoxazole, indole, benzo[1,3]-dioxole, benzo[1,2,5]-oxadiazole, isochromen-1-one, benzothiophene, benzofuran, 2,3-dihydrobenzo[1,4]-dioxine, bitheinyl, quinazolin-2,4-91,3H]dione, and 3-H—isobenzofuran-1-one, each of which may be optionally substituted by one to three groups independently selected from halogen, C R R each R each R each R each R each R each R each R each R R each R each R20 is independently H, phenyl, or the side chain of a naturally occurring alpha amino acid; each R each R or a pharmaceutically acceptable salt thereof.