Patent ID: 8975381
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An antibody capable of binding to human VEGF and mouse VEGF with Kd values within 10-fold of the other, wherein the antibody comprises the following six complementarity determining regions (CDRs): (a) a CDR-H1 comprising the amino acid sequence GFAISDYDIH (SEQ ID NO: 505); (b) a CDR-H2 comprising the amino acid sequence DIAPYAGATAYADSVKG (SEQ ID NO: 506); (c) a CDR-H3 comprising the amino acid sequence SSYAYYAAMDY (SEQ ID NO: 507); (d) a CDR-L1 comprising the amino acid sequence RASQSYAYAVA (SEQ ID NO: 493); (e) a CDR-L2 comprising the amino acid sequence DASYLYS (SEQ ID NO: 494); and (f) a CDR-L3 comprising the amino acid sequence QQAYSSPDT (SEQ ID NO: 495).