Patent ID: 8968736
Filing Date: 2015-03-03
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal antibody or an antigen-binding fragment thereof that specifically binds to glial cell-line derived neurotrophic factor (GDNF) family receptor alpha 3 (GFRα3), wherein the antibody comprises: (a) a heavy chain complementarity determining region (HCDR) 1 domain of SEQ ID NO: 148; (b) a HCDR2 domain of SEQ ID NO: 150; (c) a HCDR3 domain of SEQ ID NO: 152; (d) a light chain complementarity determining region (LCDR) 1 domain of SEQ ID NO: 156; (e) a LCDR2 domain of SEQ ID NO: 158; and (f) a LCDR3 domain of SEQ ID NO: 160.