Patent ID: 6384033
Filing Date: 2002-05-07
Classification: A61P,C07C,C07D

Abstract:
A pharmaceutical composition for treating retinal neurodegenerative disorder comprising a compound of the formula: wherein,Ar is substituted phenyl or substituted or unsubstituted aromatic heterocyclic group, wherein said phenyl group is substituted by a fluorine atom and may be further substituted with substituents; said aromatic heterocyclic group is a 5- or 6-membered aromatic heterocyclic group containing 1 to 3 atoms selected independently from the group consisting of nitrogen atom, sulfur atom, and oxygen atom; and the substituent of the further substituted phenyl group and the substituent on the aromatic heterocyclic group are a halogen atom, a cyano group, a nitro group, an alkyl group, an alkyl group substituted by halogen atom(s), an alkoxy group, and alkoxy group substituted by halogen atom(s), an alkoxycarbonyl group, an alkanoylamino group, an amino group, a phenyl group, an alkylaminocarbonylamino group, an alkoxycarbonylamino group, alkylsulfonylamino group, a carbamoyl group or carbamoyl group substituted by alkyl(s); n is 0, 1 or 2; R1 is hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, alkoxycarbonyl, carbamoyl, alkanoyl or cyano; R2 and R3 are independently substituted or unsubstituted alkyl; or any two groups of R1, R2 and R3 may be taken together with the carbon atom adjacent thereto to form cycloalkane, or all of R1, R2 and R3 may be taken together with the carbon atom adjacent thereto to form bicycloalkane or tricycloalkane, wherein the cycloalkane, the bicycloalkane and the tricycloalkane may be substituted or unsubstituted, wherein the substituent of the substituted alkyl, the substituted alkenyl, the substituted alkynyl, the substituted cycloalkane, the substituted bicycloalkane and the substituted tricycloalkane is a cycloalkyl group, a heterocyclic group, an alkoxy group, an hydroxy group, a halogen atom, an alkoxyalkoxy group, alkanoyloxy group, an amino group, an alkylamino group, a dialkylamino group, an alkanoylamino group, pyrrolidino group, a piperidino group, a piperazino group, 4-alkylpiperazino group or morpholino group, wherein the heterocyclic group is a 5- or 6-membered aromatic heterocyclic group containing 1 to 3 atoms selected independently from the group consisting of nitrogen atom, sulfur atom, and oxygen atom, or 5- or 6-membered aliphatic heterocyclic group containing 1 or 2 atoms selected independently from the group consisting of nitrogen atom, sulfur atom and oxygen atom; R4 and R5 are independently hydrogen atom or substituted or unsubstituted alkyl, wherein the substituent of the substituted alkyl is a cycloalkyl group, a heterocyclic group, an alkoxy group, an hydroxy group, a halogen atom, an alkoxyalkoxy group, alkanoyloxy group, an amino group, an alkylamino group, a dialkylamino group, an alkanoylamino group, pyrrolidino group, a piperidino group, a piperazino group, 4-alkylpiperazino group or morpholino group, wherein the heterocyclic group is a 5- or 6-membered aromatic heterocyclic group containing 1 to 3 atoms selected independently from the group consisting of nitrogen atom, sulfur atom, and oxygen atom, or 5- or 6-membered aliphatic heterocyclic group containing 1 or 2 atoms selected independently from the group consisting of nitrogen atom, sulfur atom and oxygen atom; R6 is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof; anda pharmaceutical carrier.