Patent ID: 7763271
Filing Date: 2010-07-27
Classification: A61L

Abstract:
1. A method comprising: applying a primer layer to a medical device; attaching PEG-PE micelles to the primer layer; loading a substantially water insoluble drug into the micelles; and implanting the medical device, thereby providing a means for locally delivering the substantially water insoluble drug; wherein the substantially water insoluble drug is selected from the group consisting of sirolimus, everolimus, zotarolimus, and combinations thereof; wherein the primer comprises a polymer selected from the group consisting of poly(ethylimine-g-ethylene glycol) (PEI-g-PEG), poly(ethylimine-g-hyaluronic acid) (PEI-g-HA), poly(ethylimine-g-phosphoryl choline) (PEI-g-PC), and poly(ethylimine-g-vinylpyrrolidone) (PEI-g-PVP), PEI-co-PEG, PEI-co-HA, PEI-co-PC, and PEI-co-PVP.