Patent ID: 6340478
Filing Date: 2002-01-22
Classification: A61K

Abstract:
An orally-administrable formulation for the controlled release of a granulated herb comprising a microencapsulated granulated herb having an active ingredient selected from the group consisting of hypericin, hyperforine and echinosides and at least one carrier, adjuvant or excipient therefor, characterized in that the total in vitro dissolution time of said formulation required for release of 75% of the active ingredients available from said formulation is between about 4 and about 18 hours, as determined by the U.S.P. XXIII paddle method at a paddle speed of 150 rpm, using simulated intestinal fluid without the digestive enzymes normally found in intestinal fluid, containing 0.1% w/w sodium dodecyl sulfate at pH 6.8 and a temperature of 37Â° C.