Patent ID: 6380215
Filing Date: 2002-04-30
Classification: A61P,C07D,Y02P

Abstract:
A compound of the formula: wherein:R1 is 6-membered cycloalkyl containing 1 to 3 nitrogen atoms which may have one or more amino protective groups; X is O, S or NH, and l is an integer of either 0 or 1; A1 is lower alkylene, lower alkenylene or lower alkanyl-ylidene, each of which may have one or more suitable substituent(s); Y is NH, and m is an integer of either 0 or 1; â€ƒis a group of the formula: wherein â€ƒis 5 or 6-membered N-containing heterocyclic group containing 1 to 3 nitrogen atoms which may have one or more suitable substituent(s); A2 is lower alkylene, and n is an integer of either 0 or 1; Z is whereinR3 is hydrogen or lower alkyl; A3 is lower alkylene which has one or more suitable substituents except carboxy and protected carboxy, with the proviso that when Z is â€”C(O)NHâ€”, that A3 is not lower alkylene substituted with aryl, aryl(lower)alkyl or an unsaturated heterocyclic group; and R2 is carboxy or protected carboxy; or a pharmaceutically acceptable salt thereof.