Patent ID: 6730658
Filing Date: 2004-05-04
Classification: A61K,A61P,C07K

Abstract:
A method of stimulating the growth of lymphatic endothelia, comprising steps of:(a) identifying a patient in need of stimulation of the growth of lymphatic endothelia; and (b) administering to the patient a polypeptide in an amount effective to stimulate the growth of lymphatic endothelial cells, wherein the polypeptide comprises an amino acid sequence encoded by a polynucleotide that hybridizes to the non-coding strand complementary to the cDNA sequence of SEQ ID NO: 32 under the following hybridization conditions: hybridization at 42Â° C. in a hybridization solution comprising 50% formamide, 5Ã—SSC, 20 mM Na.PO4, pH 6.8 and washing in a wash solution comprising 0.2Ã—SSC at 55Â° C., and wherein the polypeptide binds and stimulates phosphorylation of Flt4 receptor tyrosine kinase.