Patent ID: 6812227
Filing Date: 2004-11-02
Classification: A61K,C07C,C07D,C07F

Abstract:
Compounds having the formula: wherein:X is SO2 or â€”P(O)â€”R10; Y is aryl or heteroaryl, with the proviso that X and Z may not be bonded to adjacent atoms of Y; Z is O, NH, CH2 or S; R1 is hydrogen, aryl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms; R2 is hydrogen, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl of 3-6 carbon atoms, C4-C8 cycloheteroalkyl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms; or R1 and R2, together with the atom to which they are attached, may form a ring wherein R1 and R2 represent a divalent moiety of the formula: â€ƒwherein Q=a carbon-carbon single or double bond, O, S, SO, SO2, â€”Nâ€”R11, or â€”CONR14; m=1-3; r=1 or 2, with the proviso that when Q is a bond, r is equal to 2; R3 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, C4-C8 cycloheteroalkyl, aralkyl, or heteroaralkyl; or R1 and R3, together with the atoms to which they are attached, may form a 5 to 8 membered ring wherein R1 and R3 represent divalent moieties of the formula: or R1 and R3, together with the atoms to which they are attached, may for a 5-, 7-, or 8-membered ring wherein R1 and R3 represent divalent moieties of the formula: wherein Q and m are as defined above; A is aryl or heteroaryl; is 0-3; u is 1-4; R4 and R5 are each, independently, hydrogen or alkyl of 1-6 carbon atoms, â€”CN, or â€”CCH; R6 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, or â€”C5-C8-cycloheteroalkyl; R8 and R9 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, aralkyl, heteroaryl, heteroaralkyl, or â€”C4-C8-cycloheteroalkyl; R10 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl or heteroaryl; R11 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl, â€”S(O)nR8, â€”COOR8, â€”CONR8R9, â€”SO2NR8R9 or â€”COR8; R12 and R13 are independently selected from H, â€”OR8, â€”NR8R9, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl, â€”COOR8; â€”CONR8R9; or R12 and R13 together form a â€”C3-C6-cycloalkyl of 3-6 carbon atoms or a â€”C5-C8-cycloheteroalkyl ring; or R12 and R13, together with the carbon to which they are attached, form a carbonyl group; with the proviso that R10 and R12 or R11 and R12 may form a cycloheteroalkyl ring when they are attached to adjacent atoms; R14 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms or cycloalkyl of 3-6 carbon atoms; and n is 0-2; or a pharmaceutically acceptable salt thereof.