Patent ID: 8614252
Filing Date: 2013-12-24
Classification: A61P,C07B,C07C

Abstract:
1. A process for manufacture of crystalline R(+)-N-propargyl-1-aminoindan characterized by a powder x-ray differaction pattern having peaks at 8.5, 12.6, 16.1, and 16.9 in degrees two theta ±0.2, comprising: a. obtaining a first organic solution of liquid R(+)-N-propargyl-1-aminoindan in isopropanol; b. completely evaporating the isopropanol from the first organic solution under vacuum to form a residue; c. dissolving the residue in isopropanol to form a second organic solvention; d. completely evaporating the isopropanol from the second organic solvention under vacuum to form a second residue; and e. maintaining the second residue at a temperature between 0 between and 25° C. to form crystalline R(+)-N-propargyl-1-aminoindan.