Patent ID: 6727258
Filing Date: 2004-04-27
Classification: A61K,A61P,C07D

Abstract:
A method for providing cardioprotection, neuroprotection, pain management, reduction of free fatty acids, triglycerides, or glucose levels, adjunct therapy in diabetes, treatment of GI disorders, treatment of glaucoma; treatment of sleep disorders; treatment of cardiac disarrythmias (peroxysmal supraventricular tachycardia, treatment of congestive heart failure or treatment of inflammation comprising administering to a patient in need of treatment thereof an effective amount to treat the disorder of a compound of formula IA: whereinR2 is H, C(&boxH;O)R8; R8 is H, alkyl, substituted alkyl, aralkyl, substituted aralkyl, aryl, or substituted aryl; R3 and R4 are independently H, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, hydroxy, alkylsulfonyloxy, arylsulfonyloxy, substituted arylsulfonyloxy, alkoxy, alkylthio, or arylthio; or if R3 and R4 are both alkoxy or alkylthio, may form a 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, 1,3-dithiolan-2-yl, or 1,3-dithian-2-yl group; or together R3 and R4 may form a carbonyl oxygen; R5, R6, and R7 are independently H, alkyl, substituted alkyl, aryl, substituted aryl, halogen, hydroxy, nitro, amino, substituted amino, disubstituted amino, alkoxy, aryloxy, alkylthio, arylthio, sulfonamido, or substituted sulfonamido; or together R5 and R6 or R6 and R7 may be CH&boxH;CHâ€”CH&boxH;CH, such that they form a fused aromatic ring; A and B are independently O, S, or Nâ€”R8; except either A or B, but not both A and B, may independently represent a carbonâ€”carbon single bond; m and n are independently 0, 1 or 2; when A or B represents a carbon-carbon single bond then m plus n equals 2; when neither A nor B represent a carbon-carbon single bond then m plus n equals 1; and X is CH&boxH;CH, CH&boxH;N, N&boxH;CH, O, S, or Nâ€”R8.