Patent ID: 9216976
Filing Date: 2015-12-22
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
1. A method of making a targeted antioxidant compound, comprising: a. reacting an aldehyde of structure R1—C(O)—H— with (R)-2-methylpropane-2-sulfinamide to foam an imine, in which R b. reacting a terminal alkyne-1-ol (HCC—R c. reacting the imine with the alkyne in the presence of an organozirconium catalyst to produce an alkene; d. acylating the alkene to produce a carbamate; e. removing the t-butyldiphenylsilyl group from the carbamate to produce an alcohol; f. oxidizing the alcohol to produce a carboxylic acid; and g. reacting carboxylic acid with a nitroxide-containing compound comprising one of a hydroxyl or amine in a condensation reaction to produce the antioxidant compound.