Patent ID: 6846835
Filing Date: 2005-01-25
Classification: A61P,C07C,C07D

Abstract:
1. A compound which is represented by the following general formula (I): wherein A is a 6-membered single nitrogen-containing ring having: (i) the formula (a wherein B 11 and B 12 signify, independently of each other, a C 1 —C 6 saturated or unsaturated aliphatic hydrocarbon group; k signifies 0, 1 or 2; R 2 and R 3 signify, either independently of each other, an optionally phenyl-substituted lower alkyl; and X − signifies an anion, provided that the sum of carbon atoms of B 11 and B 12 and k does not exceed 13; or (ii) the formula (a wherein B 11 and B 12 signify, independently of each other, C 1 -C 6 saturated or unsaturated aliphatic hydrocarbon; k signifies 0, 1 or 2; R 20 signifies hydrogen or a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl, provided that the sum of carbon atoms of B 11 and B 12 and k does not exceed 13; or (iii) the formula (b wherein B 21 and B 22 signify, independently of each other, a C 1 -C 6 saturated or unsaturated aliphatic hydrocarbon group; m signifies 0, 1 or 2; R 6 signifies hydrogen, lower alkyl or a group represented by —N(R 8 )R 9 ; R 8 and R 9 signify, independently of each other, hydrogen or lower alkyl; and R 71 signifies hydrogen or lower alkyl, provided that the sum of carbon atoms of B 21 and B 22 and m does not exceed 13; or (iv) the formula (b wherein B 21 and B 22 signify, independently of each other, C 1 -C 6 saturated or unsaturated aliphatic hydrocarbon; m signifies 0, 1 or 2, provided that the sum of carbon atoms of B 21 and B 22 and m does not exceed 13; Ar is phenyl optionally having substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkenyl and lower alkoxy; and R or a pharmaceutically acceptable salt thereof.