Patent ID: 6825194
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A hexacyclic compound of formula [1], whereinZ isâ€”NHâ€”(&boxH;X)â€”N(R1)â€” or â€”N&boxH;C(R2)â€”N(R1)â€”; R1 is hydrogen; (C1-C10) alkyl, (C1-C10) alkyl substituted with one to three moieties independently selected from the group consisting of (C1-C5) alkoxy, hydroxy, halogen, amino, mono-(C1-C5) alkylamino, di-(C1-C5) alkylamino, (C3-C7) cycloalkyl, a heterocyclic ring and an aryl ring in which the aryl ring is unsubstituted or substituted with one to three moieties independently selected from the group consisting of hydroxy, alkoxy, halogen, amino, mono-(C1-C5) alkylamino and di-(C1-C5) alkylamino; R2 is hydrogen; amino; C1-C5) alkyl; (C1-C5) alkoxy; (C1-C5) alkylthio; mono-(C1-C5) alkylamino; di-(C1-C5) alkylamino and di-(C1-C5) alkylamino substituted with one to three moieties independently selected from the group consisting of (C1-C5) alkoxy, hydroxy, halogen, amino, (C3-C7) cycloalkyl, a heterocyclic ring and an aryl ring in which the aryl ring is unsubstituted or substituted with one to three moieties independently selected from the group consisting of hydroxy, (C1-C5) alkoxy, amino, mono-(C1-C5) alkylamino and di-(C1-C5) alkylamino; R3 and R4 are independently hydrogen, halogen or (C1-C5) alkyl; and X is oxygen or sulfur; or a pharmaceutically acceptable salt thereof.