Patent ID: 6858647
Filing Date: 2005-02-22
Classification: A61K,A61P,A61Q,Y10S

Abstract:
1. A method for killing bacteria or hindering the proliferation of bacteria, said method comprising administering to an individual subject infested or infected with a colonization of bacteria, a bactericidally or bacteriostatically effective amount of at least one retinoid compound selected from the group consisting of: 6-[3-(1-adamantyl)-4-methoxy-5-hydroxyphenyl]-2-naphthoic acid; 4-[4-(6-methoxymethoxy-4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 4-[4-(6-methoxy-4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 6-[2-methyl-4-hydroxy-5-(1-adamantyl)phenyl]-2-naphthoic acid; 4-[3-(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)prop-1-ynyl]benzoic acid; 2-hydroxy-4-[4-(4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 2-[3-(1-adamantyl)-4-methoxyphenyl)ethynyl]-4-thiophenecarboxylic acid; 4-[4-(4,4′-dimethylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 4-hydroxy-2′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 2″-hydroxy-2′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-(1,1′;4′,1″]terphenyl-4″-carboxylic acid; 6-(3-adamantan-1-yl-5-bromo-4-hydroxyphenyl)naphthalene-2-carboxylic acid; 4-[4-(6,4′-dimethylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 2′-(4,4-dimethylthiochroman-6-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 2′-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtho[2,3-b]thiophen-2-yl)benzoic acid; 4-[(6-hydroxy-7-(1-adamantyl)-2-naphthyl]benzoic acid; 4-(2-nonyloxyimino-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetylamino]benzoic acid; 4-[3-adamantan-1-yl-4-(2-methoxyethoxymethoxy)phenylethynyl)-2-hydroxybenzoic acid; 4-[[3-(1-adamantyl)-4-[(2-methyl-3-hydroxypropyloxy)phenyl]ethynyl]]benzoic acid; 2-hydroxymethyl-5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroanthracen-2-yl)phenol; 4-[4-(4′-propylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 2-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-ylselanylethynyl)benzoic acid; 2′-(3-methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 6-[butoxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]naphthalene-2-carboxylic acid; 4-[3-(1,1-dimethyldecyl)-4-methoxybenzoylamino]benzoic acid; 4-(3-adamantan-1-yl-4-hexyloxybenzoylamino)benzoic acid; 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthylmethanol; 2-hydroxy-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroanthracen-2-yl)benzoic acid; 2-(3-adamantan-1-yl-4-hydroxyphenyl)benzofuran-5-carboxylic acid; 4-(6-methoxyethoxymethoxy-7-(1-adamantyl)-2-naphthyl]salicylic acid; (E)-4-[4-(5-methoxymethoxy-4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 4-[4-(3-methoxy-4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-ylselanylethynyl)benzoic acid; 2-methoxymethoxy-2′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 2-hydroxy-2′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 4-[(Z)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-undecenamido]benzoic acid; 4-[4-(4′-methylbiphenyl-2-yl)but-3-en-1-ynyl]benzoic acid; 2′-propoxy-5′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylic acid; 4-[2-heptyloxyimino-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetylamino]benzoic acid; 6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)naphthalene-2-carboxylic acid amide; (2-dimethylaminoethyl)amide of 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid; 2-hydroxy-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylselanylethynyl)benzoic acid; 2′-(3-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; 3-hydroxy-2′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1′;4′,1″]terphenyl-4″-carboxylic acid; and 3-(5′-adamantan-1-yl-4′-methoxy-2′-methylbiphenyl-3-yl)acrylic acid.