Patent ID: 8153120
Filing Date: 2012-04-10
Classification: A61K,A61P,G01N

Abstract:
1. In a method for treating cancer in a mammalian subject by (a) isolating PBMCs from a subject; (b) exposing the PBMCs in vitro to a protein conjugate comprising granulocyte macrophage colony stimulating factor (GM-CSF) covalently linked to a soluble peptide antigen selected from the group consisting of a tumor associated antigen (TAA) and an oncogene product, under conditions effective to activate the PBMCs; (c) administering the activated PBMCs to the subject; (d) repeating step (a) and (b) at least 10 days after previous step (c) has occurred, an improvement for determining whether the subject has shown a positive therapeutic response to the treatment and therefore whether the subject is a candidate for additional treatment with activated PBMCs, comprising