Patent ID: 8674110
Filing Date: 2014-03-18
Classification: A61P,C07D

Abstract:
1. A process for the production of a compound of formula I wherein R is 11 CH 3 , C( 3 H) 3 , (CH 2 ) n - 18 F, n being 1, 2,,3, or 4, in free base or an acid addition salt thereof, comprising the steps of a) for the production of a compound of formula Ia wherein R a is, respectively, 11 CH 3 or C( 3 H) 3 , reacting a compound of formula II with, respectively, 11 CH 3 I or C( 3 H) 3 I, in the presence of a base; or b) for the production of a compound of formula Ib wherein Rb is, respectively, (CH 2 ) n - 18 F, (CH 2 ) n - 123 I, or (CH 2 ) n - 76 Br, reacting a compound of formula III wherein n is as defined above and X is OTs or OMs, with, respectively, 18 F — , 123 I — or 76 Br — or, reacting the compound of formula II with a compound of formula X- Rb, wherein X and Rb are as defined above, and recovering the resulting compound of formula I in free base form or in the form of an acid addition salt.