Patent ID: 8420071
Filing Date: 2013-04-16
Classification: A61K,A61P,C12N

Abstract:
1. A method for treating a subject suffering from a central nervous system tumor composed of cells, said method comprising: administering to the subject a replication competent aneurovirulent γ34.5 deleted herpes simplex virus (HSV) comprising a nucleic acid sequence encoding for interleukin-12, wherein the nucleic acid sequence is inserted within a γ34.5 gene deletion such that the replication competent aneurovirulent herpes simplex virus contains at most two nucleic acid sequences encoding for interleukin-12; and allowing sufficient time for the HSV to be expressed in a portion of the cells of the tumor and interleukin-12 to exit the portion of cells to contact bystander cells to increase survival time of the subject and thereby treat the subject.