Patent ID: 9205083
Filing Date: 2015-12-08
Classification: A61K

Abstract:
1. A method of increasing the metabolic lifetime of dextromethorphan, comprising co-administering erythrohydroxybupropion or bupropion with dextromethorphan to a human being once or twice a day for at least eight consecutive days, wherein erythrohydroxybupropion or bupropion is administered in an amount that results in an AUC 0-12 of erythrohydroxybupropion in the human being, on day 8, that is at least about 200 ng·hr/mL, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the co-administration results in an AUC 0-12 of dextromethorphan that on the eighth day, is at least about 20 times the AUC 0-12 that would be achieved b administering the same amount of dextromethorphan without erythrohydroxybupropion or bupropion for eight consecutive days, and wherein dextromethorphan is present in the body of the human being at the same time as erythrohydroxybupropion or bupropion.