Patent ID: 6177420
Filing Date: 2001-01-23
Classification: A61P,C07J

Abstract:
A 20-aralkyl-5.alpha.-pregnane compound having the general formula I, or a pharmaceutically acceptable salt thereof, ##STR6##whereinR.sub.1 is (H,OR), (H,OSO.sub.3 H) or NOR;R is H, (C.sub.1-6)alkyl or (C.sub.1-6)acyl;each of R.sub.2 and R.sub.3 is independently hydrogen or (C.sub.1-6)alkyl;X is a straight chain divalent C.sub.1-8 hydrocarbon radical, optionally comprising a double or a triple bond; or X is --(CH.sub.2).sub.m --CR.sub.7 R.sub.8 --; m=0-4;at least one of R.sub.7 and R.sub.8 is (C.sub.1-4)alkyl, hydroxy, (C.sub.1-4)alkoxy or halogen; the other, if present, being hydrogen; orR.sub.7 and R.sub.8 together represent O or NOR';R' is H, (C.sub.1-6)alkyl or (C.sub.1-6)acyl;each of R.sub.4, R.sub.5 and R.sub.6 is independently hydrogen, hydroxy, (C.sub.1-4)alkoxy, halogen, NR.sub.9,R.sub.10 or (C.sub.1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo;each of R.sub.9 and R.sub.10 is independently hydrogen or (C.sub.1-4)alkyl; andthe dotted lines indicate a .DELTA..sup.7 or a .DELTA..sup.8 double bond, or a pair of conjugated double bonds selected from .DELTA..sup.7,14, .DELTA..sup.8,14 and .DELTA..sup.6,8(14) ;provided that (3.beta.,4.alpha.,24E)-25-(4-hydroxyphenyl)-4-methyl-26,27-dinorcholesta-7 ,24-dien-3-ol (gramisterol) is excluded.