Patent ID: 8101763
Filing Date: 2012-01-24
Classification: C07D

Abstract:
1. A process for preparing compounds of formula 1 wherein X − denotes an anion with a single negative charge, R denotes hydrogen, hydroxy, methyl, ethyl, —CF 3 , CHF 2 or fluorine; R 1 and R 2 which may be identical or different, denote —C 1 -C 5 -alkyl, which may optionally be substituted by —C 3 -C 6 -cycloalkyl, hydroxy or halogen, or R 1 and R 2 together denote a —C 3 -C 5 -alkylene bridge; R 3 , R 4 , R 3′ and R 4′ , which may be identical or different, denote hydrogen, —C 1 -C 4 -alkyl, —C 1 -C 4 -alkyloxy, hydroxy, —CF 3 , —CHF 2 , CN, NO 2 or halogen R 6 and R 6′ together represent a single bond; comprising the step of reacting in one step a compound of formula 2 wherein Y − denotes an anion with a single negative charge, and R 1 and R 2 have the meanings given above, with a compound of formula 3 wherein R 5 denotes a group selected from among hydroxy, methoxy, ethoxy, O—N-succinimide, O—N-phthalimide, phenyloxy, nitrophenyloxy, fluorophenyloxy, pentafluorophenyloxy, vinyloxy, 2-allyloxy, —S-methyl, —S-ethyl and —S-phenyl and wherein R, R 3 , R 3′ , R 4 , R 4′ , R 6 and R 6′ have the meanings given above.