Patent ID: 6800603
Filing Date: 2004-10-05
Classification: A01N,A61F,A61K,A61L,C07K,G01N

Abstract:
A method of stimulating production of a neural cell adhesion molecule, comprising contacting a mammalian neuron with a morphogen comprising a dimeric protein, the dimeric protein having one or more of the following:(1) a conserved C-terminal six-cysteine skeleton 60% identical to residues 43-139 of SEQ ID NO: 5; (2) a conserved C-terminal seven-cysteine skeleton 70% homologous to residues 38-139 of SEQ ID NO: 5; (3) a conserved C-terminal six-cysteine skeleton 70% homolonous to residues 43-139 of SEQ ID NO: 5; and (4) an amino acid sequence of: human OP-1 (SEQ ID NO: 5), mouse OP-1 (SEQ ID NO: 6), human OP-2 (SEQ ID NO: 7), mouse OP-2 (SEQ ID NO: 8), BMP5(fx) (SEQ ID NO: 27), BMP6(fx) (SEQ ID NO: 28), Vgr-1(fx) (SEQ ID NO: 13), 60A(fx) (SEQ ID NO: 24), BMP2A(fx) (SEQ ID NO: 9), BMP-2B(fx) (SEQ ID NO: 10), DPP(fx) (SEQ ID NO: 11), or Vgl (fx) (SEQ ID NO: 12), wherein said neural cell adhesion molecule comprises N-CAM or L1, and wherein said morphogen stimulates a detectable increase in the production of said neural cell adhesion molecule by said mammalian neuron.