Patent ID: 6479472
Filing Date: 2002-11-12
Classification: A61K,A61P,C07F,Y02A

Abstract:
A method of treating protozoal and fungal diseases which comprises administering to a host having a protozoal or fungal disease an effective amount of a compound of formula I in whichR is a linear or branched alkyl radical having 10 to 24 carbon atoms, which can also contain one to three double bonds or triple bonds; R1 and R2 independently of each other are hydrogen or a linear, branched or cyclic hydrocarbon radical having 1 to 6 carbon atoms, the hydrocarbon radical being saturated or unsaturated and optionally containing a substituent selected from the group consisting of Cl, OH and NH2, wherein two of the hydrocarbon radicals may be bonded together to form a ring; A is a single bond or one of the groups of the formulae: â€ƒin which the groups having formulae (II) to (VI) are oriented in such a way that the oxygen atom is bonded to the phosphorous atom of compound (I); X is an oxygen or sulfur atom or NH when A is a single bond, or an oxygen or sulfur atom when A is one of the groups having formulae (II) to (IV); y is equal to 0 or a natural number between 1 and 3; and m and n independently of one another are 0 or a natural number selected such that the sum of m+n equals 4.