Patent ID: 6288084
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A method of treating a disease associated with aberrant leukocyte recruitment and/or activation mediated by chemokine receptor function, comprising administering to a subject in need thereof an effective amount of a compound having the structural formula: ##STR11##or physiologically acceptable salt thereof, wherein:n is an integer from one to four;M is >CR.sup.1 R.sup.2 ;R.sup.1 is --H, --OH, an aliphatic group, --O-(aliphatic group), --O-(substituted aliphatic group), --SH, --S-(aliphatic group), --S-(substituted aliphatic group), --OC(O)-(aliphatic group), --O--C(O)-(substituted aliphatic group), --CN, --COOH, --CO--NR.sup.3 R.sup.4 or --NR.sup.3 R.sup.4 ;R.sup.2 is --OH, an acyl group, a substituted acyl group, --NR.sup.5 R.sup.6,a linear C.sub.2 -C.sub.20 alkyl, alkenyl or alkynyl group, a substituted linear C.sub.2 -C.sub.20 alkyl, alkenyl or alkynyl group, a substituted or unsubstituted cyclic or branched C.sub.3 -C.sub.20 alkyl or alkenyl group, a substituted or unsubstituted branched C.sub.1 -C.sub.10 alkynyl group a substituted or unsubstituted cyclic C.sub.9 -C.sub.20 alkynyl group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; wherein:said acyl group is an aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently --H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; orR.sup.1 and R.sup.2, R.sup.3 and R.sup.4, or R.sup.5 and R.sup.6 taken together with the atom to which they are bonded, form a substituted or unsubstituted non-aromatic heterocyclic ring; andAr.sup.1 and Ar.sup.2 are each, independently, a substituted or unsubstituted imidazolyl, thienyl, furanyl, pyridyl, pyrrolyl, pyrmidyl, pyrazinyl, pyridazinyl, pyrazolyl, thiazolyl, tetrazolyl or oxazolyl group.