Patent ID: 6471992
Filing Date: 2002-10-29
Classification: A61K,A61P,B33Y

Abstract:
A pharmaceutical composition for administration to a subject comprising one or more active ingredients and a rapidly dispersing, non-compressed solid matrix including said one or more active ingredients, said matrix having a layered three-dimensional shape with a defined microstructure and comprising a bulk material and a binder, said bulk material comprising a pharmaceutically acceptable compound in particulate form and said binder comprising a pharmaceutically acceptable, substantially water-soluble substance having the capacity to adhere to and bind together the particles of said bulk material, to maintain the three-dimensional shape of said matrix in the absence of moisture and to permit said composition to exhibit hardness and friability characteristics adequate for storage and handling, provided that said three-dimensional shape is disrupted within a time period of less than about ninety seconds upon contact of said composition with moisture, with release of said one or more active ingredients to said subject.