Patent ID: 6716436
Filing Date: 2004-04-06
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A cosmetic composition for slimming which comprises, in combination with a cosmetically acceptable excipient, at least one nitric oxide precursor compound which is a L-arginine analogue or one of its derivatives or salts, said compound having the following general formula (I): wherein:R1 is selected from the group consisting of a hydroxyl group, an unsubstituted aminoacid selected from the group consisting of cysteine, hydroxyproline, leucine, isoleucine, methionine, phenylalanine, proline, tryptophan, valine, pyroglutamic acid, histidine, citrulline, homoserine, norvaline, ornithine, penicillamine and sarcosine, and an aminoacid substituted on its free &agr;-amino function and selected from the group consisting of cysteine, hydroxyproline, leucine, isoleucine, methionine, proline, tryptophan, valine, pyroglutamic acid, histidine, citrulline, homoserine, norvaline, ornithine, penicillamine and sarcosine, said aminoacid being bound by a peptidic bond, R2 is selected from the group consisting of an alkoxy group, a silyloxy group, an unsubstituted aminoacid selected from the group consisting of cysteine, hydroxyproline, leucine, isoleucine, methionine, phenylalanine, proline, tryptophan, valine, pyroglutamic acid, histidine, citrulline, homoserine, norvaline, ornithine, penicillamine and sarcosine, and an aminoacid substituted on its free &agr;-carboxylic acid function, and selected from the group consisting of cysteine, hydroxyproline, leucine, isoleucine, methionine, phenylalanine, proline, tryptophan, valine, pyroglutamic acid, histidine, citrulline, homoserine, norvaline, ornithine, penicillamine and sarcosine, said aminoacid being bound by a peptidic bond, and n is 3 or 4.