Patent ID: 8426589
Filing Date: 2013-04-23
Classification: C07D

Abstract:
1. A process for preparing a compound represented by the formula (III): wherein R R a salt, or a solvate thereof; comprising: Reaction A, in which a compound represented by the formula (I): wherein R wherein L R is reacted with 1.0 to 1.5 equivalent of a compound represented by the formula: (R and 3 to 4 equivalent of one or more metallic reagent(s) selected from the group consisting of Grignard reagent, sodium hydride, alkyllithium, alkenyllithium, alkynyllithium, phenyllithium, and lithium amide; and reaction B, in which a product of reaction A is reacted with 1-propynyl metal acetylide; are carried out substantially as one step by continuously conducting these two reactions.