Patent ID: 6818453
Filing Date: 2004-11-16
Classification: C07D,G01N

Abstract:
A non-fluorescent label which is suitable for making a charge-transfer fluorescent probe having a donor-bridge-acceptor structure, characterized in that the label comprises a maleimide moiety and a donor-bridge-acceptor structure, wherein the bridge is an 8-azabicyclo[3,2,1]octane comprising group which leads to an all-trans orbital coupling of the donor and the acceptor, and the donor-bridge-acceptor structure has a higher energy charge-transfer emissive state than at least one non-emissive state of the part of the label comprising the maleimide moiety, which non-emissive state must have a higher energy than the charge-transfer emissive state of the donor-bridge-acceptor structure after coupling of the maleimide moiety to a suitable system.