Patent ID: 7851598
Filing Date: 2010-12-14
Classification: A61K,A61P,C07K,G16B

Abstract:
1. An antibody that binds to the extracellular portion of the human PD-1 receptor at a membrane proximal region and said antibody binds to an epitope comprising SEQ ID NO: 44, SEQ ID NO: 46, SEQ ID NO: 48, SEQ ID NO: 50, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 56 or SEQ ID NO: 61, wherein: a) said antibody does not only bind to a peptide consisting of LAAFPEDRSQPGQDCR (SEQ ID NO: 61), the human PD-1 equivalent of the C′-D loop of human CD28; and b) said antibody induces superagonistic signaling of the PD-1 receptor by binding to a membrane proximal region of the human PD-1 receptor that is within 75 Å of a cell surface or wherein said antibody binds to a membrane proximal region of human PD-1 expressed on the surface of a cell and holds the cell surface within 200 Å of a substrate to which said antibody is immobilized.