Patent ID: 6562334
Filing Date: 2003-05-13
Classification: A61K,C07K,C12N,Y10S

Abstract:
A method of treating a tumor, dermatitis, or an allergic disease comprising injecting a mammal selected from the group consisting of dogs and cats with an injection comprising an isolated canine interleukin 12, having a P40 subunit and a P35 subunit, and at least one activity selected from the group consisting of an activity to induce IFN-&ggr; expression in lymphocytes, an activity to promote proliferation of canine lymphoblasts, and an activity to kill canine tumor cells by activating canine leukocytes, wherein said P40 subunit has an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1 and wherein said P35 subunit has an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2, wherein 1) said tumor is selected from the group consisting of a mammary gland tumor, eosinophilic granuloma, epidermoid, ecphyma, lipoma, othematoma, pulmonary edema, dermal caulescent soft tumor, and anal tumor; 2) said dermatitis is selected from the group consisting of external acoustic meatus inflammation, dermatitis, eczema, dermatomycosis, pyoderma, allergic dermatitis, urtication, traumatic dermatitis, and alopecia; and 3) said allergic disease is pollinosis.