Patent ID: 6476015
Filing Date: 2002-11-05
Classification: A61P,C07D

Abstract:
A monocyclic &bgr;-lactam compound of the formula: or a salt or hydrate thereof, wherein:â€”C(R1)3 is methyl, ethyl, â€”CH2Ph or benzyl; â€”X(R2)n is methoxy, hydrogen, or X(R2)n and R4 forms a spirocycle R3 is acetyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl(C2-C6)alkenyl, heteroaryl(C2-C6)alkenyl, aryl(C2-C6)alkynyl or heteroaryl(C2-C6)alkynyl; wherein any aryl or heteroaryl is optionally substituted with halo, nitro, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C15)alkyl, (C3-C8)cycloalkyl-C2-C15)alkenyl, (C3-C8)cycloalkyl(C2-C15)alkynyl, (C1-C15)alkoxy, (C1-C15)alkanoyl, (C1-C15)alkanoyloxy, C(O)O(C1-C6)alkyl, C(&boxH;O)N((C1-C6)alkyl)2, or N((C1-C6)alkyl)2; R4 is hydrogen, or X(R2)n and R4 forms a spirocycle; R5 is hydrogen; and excluding the compounds 1-thiomethyl-3-methoxy-4-phenylethynyl-2-oxoazetidine, and 1-thiomethyl-3-methoxy-4-(O-acetyl)phenylethynyl-2oxoazetidine.