Patent ID: 6403586
Filing Date: 2002-06-11
Classification: A61P,C07D

Abstract:
A pyridazine derivative represented by the following formula (1): whereinR1 represents a lower alkoxyl group, or a lower alkylthio group; R2 represents a hydrogen atom, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R3 represents a linear or branched lower alkyl or lower alkenyl group, wherein said alkyl or alkenyl group may have one or more substituents each independently selected from the group consisting of a hydroxyl group, a halogen atom, a cyano group, a lower cycloalkyl group, a phenyl group which may be substituted, a naphthyl group which may be substituted, a pyridyl group which may be substituted, wherein said phenyl, naphthyl or pyridyl groups when substituted have 1 to 3 substituents independently selected from the group consisting of a halogen atom, a nitro group, an amino group, and a carbonylamino group substituted with a phenyl, naphthyl or pyridyl group; and a carbamoyl group that may be substituted with one or more substituents independently selected from the group consisting of a lower alkyl group, a lower alkyl group substituted by one or more hydroxy groups, a lower alkyl group substituted with phenyl, naphthyl or pyridyl, and a phenyl, naphthyl or pyridyl group which may be substituted with one or more lower alkythio groups; R4 represents a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group which may have one or more substituents each independently selected from a lower alkyl group, a phenyl, naphthyl or pyridyl group, or by a lower alkyl group substituted by one or more phenyl, naphthyl or pyridyl groups, a thiocarbamoyl group which may have one or more substituents each independently selected from a lower alkyl group, a phenyl, naphthyl or pyridyl group, or by a lower alkyl group substituted by one or more phenyl, naphthyl or pyridyl groups, a amino group which may have one or more substituents independently selected from a lower alkoxycarbonyl group which may be substituted by phenyl, naphthyl or pyridyl, a C1-C5 acyl group, a lower alkyl group which may be optionally substituted by phenyl, naphthyl or pyridyl, a lower alkylsulfonlyl group, or a ureido group, which may be substituted by one or more lower alkyl groups; wherein the dashed line in formula I indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond; or a salt thereof.