Patent ID: 6482958
Filing Date: 2002-11-19
Classification: C07D

Abstract:
A process for the preparation of a compound of formula II wherein Y is halogen or â€”OR; andâ€”OR is an aryloxy group or a group of formulae â€”Oâ€”(CO)â€”Râ€², â€”Oâ€”(CO)â€”Oâ€”Râ€³ or â€”Oâ€”(PO)â€”(ORâ€³)2, wherein Râ€² is alkyl, perfluoro-C1- 20-alkyl, aryl, Râ€³ is alkyl, aryl or benzyl; comprising reacting a thiophene carbaldehyde of formula with a reagent of the formula vinyl-metal-Xwherein -metal-X is â€”MgCl, â€”MgBr, â€”MgI or â€”Li, followed by reaction with an acid derivative selected from a group consisting of (Râ€²â€”CO)2O, Râ€³Oâ€”(CO)â€”Cl, Clâ€”(PO)(ORâ€³)2 or Râ€³â€”(CO)â€”Hal, wherein Râ€² is alkyl, perfluoro-C1- 20-alkyl, aryl, Râ€³ is alkyl, aryl or benzyl and Hal is Cl or Br to form said compound II.