Patent ID: 6933122
Filing Date: 2005-08-23
Classification: G01N

Abstract:
1. A method for determining whether an agent is capable of modulating the binding of a nARIA polypeptide having the sequence identified as SEQ ID. NO:4 to a receptor selected from the group consisting of erbB2, erbB3 and erbB4, which method comprises: (a) contacting the nARIA polypeptide with the agent and a receptor selected from the group consisting of erbB2, erbB3 and erbB4, under conditions permitting the binding of the nARIA polypeptide to the receptor; (b) measuring the amount of nARIA polypeptide in step (a) bound to the receptor; and (c) comparing the amount so measured in step (b) to the amount of the nARIA polypeptide which would bind to the receptor if in the absence of such agent, a difference in the amounts indicating that the agent modulates the binding of the nARIA polypeptide to the receptor.