Patent ID: 7825265
Filing Date: 2010-11-02
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: n is an integer selected from the group consisting of 1, 2, 3, 4, 5 and 6; R R each Y is separately selected from the group consisting of methylene, methylene substituted with one or two R provided that the ring defined by the Y groups is not a 4-substituted piperidine, and provided that when the ring defined by the Y groups is 2,6-dioxane, where position 1 of the dioxane is the position to which the A group is attached, then A is a substituted aryl, and provided that when one Y is oxygen, a second Y is C═O, and a third Y is nitrogen, then the combination of oxygen, C═O, and nitrogen forms an oxazinanone two Y groups are optionally bound together to form a substituted or unsubstituted C R any bond represented by a dashed and solid line represents a bond selected from the group consisting of a single bond and a double bond; A is selected from the group consisting of substituted heteroaryl, unsubstituted heteroaryl, substituted heteroalicyclyl, unsubstituted heteroalicyclyl, unsubstitued aryl, and substituted aryl, wherein the heteroaryl is selected from the group consisting of furan, thiophene, phthalazinone, pyrrole, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, triazole, thiadiazole, pyran, pyridine, pyridazine, pyrimidine, and pyrazine; A is optionally bound to one Y group to form a substituted or unsubstituted C Z is oxygen or sulfur; and each R provided that when every Y is a substituted or unsubstituted methylene, then A is not a substituted or unsubstituted aryl; and provided that A and the ring defined by the Y groups and the carbon atom to which they are attached are not both simultaneously carbocyclic rings or heterocyclic rings.