Patent ID: 9090589
Filing Date: 2015-07-28
Classification: A61K,A61P,C07D

Abstract:
1. A method of reducing expression of neuronal nitric oxide synthase, said method comprising: providing a compound selected from compounds of a formula wherein R 1 is selected from H, halogen, methyl and halomethyl moieties; R 2 is selected from H, alkyl and haloalkyl moieties; Z is selected from O and NH; and R 4 is selected from H, alkyl, halogen and haloalkyl moieties, and salts thereof; and contacting said compound with a cellular medium comprising one of human melanocytes, melanoma cells and a combination thereof, said compound in an amount sufficient to reduce induction of neuronal nitric oxide synthase expression, thereby reducing ultra-violet induced nitric oxide production in a human melanocyte or melanoma cell.