Patent ID: 9133519
Filing Date: 2015-09-15
Classification: C12Q

Abstract:
1. A method for culling, selecting, or breeding a mammalian subject, comprising: determining, using a biological sample from the subject, a presence or absence of at least one EDN2 gene mutation, or the genotype of at least one EDN2 gene single nucleotide polymorphism (SNP) selected from the SNP group consisting of SNP105 (nucleotide position 105,288,174 on BTA3 (UMD 3.1)), SNP208 (nucleotide position 105,298,664 on BTA3 (UMD 3.1)), and SNP272 (nucleotide position 105,305,070 by on BTA3 (UMD 3.1)), that segregates with resistance and/or tolerance to Map tissue infection, wherein said step of determining a presence or absence of at least one EDN2 gene mutation comprises determining, based thereon, at least one of susceptibility, resistance or tolerance of the subject to at least one of culling, selecting, or breeding the subject, based on the determining of at least one of susceptibility, resistance or tolerance of the subject to Map infection.