Patent ID: 8754125
Filing Date: 2014-06-17
Classification: A61K,A61P

Abstract:
1. A sterile oil-in-water emulsion, comprising propofol in an amount from about 1% to about 8% by weight of the emulsion, a pharmaceutically acceptable propofol-dissolving oil in an amount from about 3% to about 15% by weight of the emulsion, and a pharmaceutically acceptable surfactant in an amount sufficient to stabilize the emulsion, wherein the ratio of oil to propofol is in the range of about 20:1 to about 1:1 by weight; further comprising a combination selected from the group consisting of combination (a): 4-chlorobutanol, in an amount from about 0.1% to about 0.8% by weight of the emulsion, and methylparaben, in an amount from about 0.1% to about 0.8% by weight of the emulsion; and combination (b): 4-chlorobutanol, in an amount from about 0.1% to about 0.8% by weight of the emulsion, and benzyl alcohol, in an amount from about 0.1% to about 0.8% by weight of the emulsion.