Patent ID: 8268347
Filing Date: 2012-09-18
Classification: A61K,A61P,Y02A

Abstract:
1. A formulation, comprising: free unencapsulated ciprofloxacin; a pharmaceutically acceptable excipient; and liposome-encapsulated ciprofloxacin wherein the liposomes are unilamellar, have an average particle size of about 75 nm to about 120 nm, and comprise about 29.4 mg/mL cholesterol and about 70.6 mg/mL hydrogenated soy phosphatidyl-choline (HSPC); wherein the formulation is formulated for aerosolized delivery such that the liposomes maintain integrity when aerosolized, and provide a ciprofloxacin release rate of 0.5% to 20% per hour.