Patent ID: 8974827
Filing Date: 2015-03-10
Classification: A61K,Y10S

Abstract:
1. A pharmaceutical composition comprising nanoparticles, said nanoparticles consisting of: (a) a drug having a solubility in water of less than 5 mg/mL over the pH range of 6.5 to 7.5 at 25° C., at least 90 wt % of said drug being non-crystalline; (b) a poorly aqueous soluble non-ionizable cellulosic polymer selected from the group consisting of ethylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, cellulose acetate butyrate, and mixtures thereof; and (c) a poorly aqueous soluble polymeric amphiphilic non-ionizable block copolymer, wherein the amphilphilic non-ionizable copolymer is poly(ethylene oxide-b-ε-caprolactone); wherein said nanoparticles have an average size of less than 500 nm; and comprise from 1 wt % to 80 wt % said drug, from 10 wt % to 75 wt % said non-ionizable cellulosic polymer, and from 5 wt % to 60 wt % said amphiphilic non-ionizable block copolymer.