Patent ID: 6339094
Filing Date: 2002-01-15
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 and R2 are independently hydrogen, halo, C1-C6 alkyl, hydroxy, or C1-C6 alkoxy; R5, R6, and R7, are independently hydrogen, halo, C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl, or hydroxy; R3 is hydrogen, C2-C7 alkanoyl, glycyl, or dimethylglycyl; n is 1-6; D is â€”S(O)mâ€”, â€”NHâ€”, or â€”Oâ€”, m is 0, 1, or 2; and R8 is a monocyclic or bicyclic carbocyclic or heterocyclic group, optionally substituted with one or more moieties selected from the group consisting of oxo, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halo, and trifluoromethyl; provided that when D is â€”Oâ€”, or m is 0, R8 cannot be a monocyclic carbocyclic group;or a pharmaceutically acceptable salt or solvate thereof.