Patent ID: 8580755
Filing Date: 2013-11-12
Classification: A61K,C07K,C12N

Abstract:
1. A method of treating an inflammatory joint condition in a patient comprising: providing a therapeutic agent comprising a nucleic acid molecule encoding a vascular endothelial growth factor receptor-3 (VEGFR-3) agonist selected from the group consisting of VEGF-C protein or active fragment thereof, VEGF-C C152S mutant protein or active peptide fragment thereof, and VEGF-C C156S mutant protein or active peptide fragment thereof, wherein said nucleic acid molecule is operably linked to a promoter sequence that initiates expression of the VEGFR-3 agonist in an affected joint; and administering the therapeutic agent directly to the affected joint of the patient having the inflammatory joint condition under conditions effective to initiate expression of the VEGFR-3 agonist in the joint, wherein said administering is effective to treat the inflammatory joint condition.