Patent ID: 8852634
Filing Date: 2014-10-07
Classification: A61K,A61P,C07D

Abstract:
1. A pharmaceutical composition in the form of a tablet comprising the following components a) hot melt extrudate of 30-60% of a compound of formula I wherein R is lower alkyl, lower alkoxy, halogen or trifluoromethyl R R R R R unsubstituted or substituted with an oxo group, which heterocyclic ring is directly bonded or bonded via an alkylene group to the remainder of the molecule; is a cyclic tertiary amine which may contain one additional heteroatom selected from the group consisting of oxygen, nitrogen, or sulfur, wherein any sulfur present in the ring is thio or can be oxidized to sulfoxide or sulfur dioxide by which said cyclic tertiary amine is directly attached to the remainder of the molecule; X is —C(O)N(R n and p are each independently 1 to 4; or pharmaceutically acceptable acid addition salts thereof and 10-20% of a water soluble poloxamer; wherein the tablet contains 400 mg of the compound of Formula I.