Patent ID: 6660756
Filing Date: 2003-12-09
Classification: C07C,C07D

Abstract:
A compound of formula (I), a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof; whereinR1 is C1-6alkyl which may be substituted by one or more substituents, which may be the same or different, selected from the list: halo, hydroxy, C1-6alkoxy, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, carbocyclyl, carbocyclyloxy, C1-4alkoxycarbocyclyloxy, heterocyclyl, heterocyclyloxy, â€”NR2R3, â€”NR4COR5, â€”NR4SO2R5, â€”CONR2R3, â€”S(O)pR6, â€”COR7 and â€”CO2(C1-4alkyl); or R1 is carbocyclyl or heterocyclyl, each of which may be substituted by one or more substituents from said list, which substituents may be the same or different, which list further includes C1-6alkyl; or R1 is hydrogen, C1-6alkoxy, â€”NR2 R3 or â€”NR4SO2R5; whereinR2 and R3, which may be the same or different, are carbocyclyl or heterocyclyl (each of which may be substituted by C1-4alkyl, hydroxy or C1-4alkoxy); or are hydrogen or C1-4alkyl; or R2 and R3 together with the nitrogen to which they are attached form a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(C1-4alkyl)piperazinyl group; R4 is hydrogen or C1-4alkyl; R5 is C1-4alkyl, CF3, carbocyclyl, C1-4alkylcarbocyclyl, C1-4alkoxycarbocyclyl, heterocyclyl, C1-4alkoxy or â€”NR2R3; R6 is C1-4alkyl, carbocyclyl, heterocyclyl or NR2R3; and R7 is C1-4alkyl, carbocyclyl or heterocyclyl; p is 0, 1, 2 or 3; X is the linkage â€”(CH2)nâ€” or â€”(CH2)qâ€”Oâ€”(wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxyC1-3alkyl; C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted by one or more groups R8 which may be the same or different, wherein R8 is hydroxy; mercapto; halogen; cyano; acyl; amino; mono(C1-4alkyl)amino; di(C1-4alkyl)amino; carbocyclyl or heterocyclyl (either of which is optionally substituted by C1-6alkyl, haloC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, C1-6alkylthio or halogen); C1-6alkoxy; phenoxy; C1-6alkylthio; phenylthio; or alkyl optionally substituted by C1-6alkoxy, haloC1-6alkoxy, C1-6alkylthio, halogen or phenyl; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused 5- or 6-membered carbocyclic or heterocyclyic ring, optionally substituted by C1-6alkyl, haloC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, C1-6alkylthio or halogen.