Patent ID: 6479505
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A compound of formula I, in whichR1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in whichR1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in whichR3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in whichR5 and R51 together represent an additional bond, Ar is an unsubstituted or R6- and/or R7-substituted bi- or tricyclic radical of the formula 1a or 1b, â€ƒwhere G is a 5- or 6-membered ring which optionally can contain up to 3 identical or different heteroatoms selected from the group consisting of O and N, A is a bond, â€”CH2â€”, â€”CH2â€”CH2â€”, â€”CH2â€”Oâ€”, â€”Oâ€”CH2â€”, â€”C(O)â€”, â€”Oâ€”, â€”N(H)â€”, â€”N&boxH;, â€”CH&boxH;, â€”CH&boxH;CHâ€”, â€”N&boxH;CHâ€” or â€”CH&boxH;Nâ€”, B is a bond, â€”CH2â€”, â€”C(O)â€”, â€”Oâ€”, â€”N(H)â€”, â€”N&boxH;, â€”CH&boxH; or â€”S(O)2â€”, R6 is hydroxyl, halogen, carboxyl, nitro, cyano, amino, aminocarbonyl, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkyl, trifluoromethyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyloxy, 1-4C-alkylcarbonyl, 1-4C-alkoxycarbonylamino or completely or predominantly fluorine-substituted 1-4C-alkoxy, and R7 is hydroxyl, halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy, or a pharmaceutically acceptable salt, an N-oxide, or a salt of an N-oxide of this compound.