Patent ID: 6566376
Filing Date: 2003-05-20
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein:R1 and R2 independently represent phenyl optionally substituted by halogen, C1 to 6 alkyl, nitro, cyano, hydroxy, methylenedioxy, C1 to 6 alkoxy, C1 to 6 haloalkyl, C1 to 6 haloalkoxy or C1 to 6 alkylsulphonyl; each R3 independently represents halogen, nitro, C1 to 6 alkyl, cyano, C1 to 6 haloalkyl, hydroxy or C1 to 6 alkoxy; each alkoxy group being optionally further substituted by halogen, NR5R6, CO2R7, CONR8R9, pyrazolidinone, or a five membered heteroaromatic ring incorporating one to three heteroatoms independently selected from N, O and S; said heteroaromatic ring being optionally further substituted by one or more C1 to 4 alkyl groups; n represents an interger 0 to 3; R4 represents hydrogen, hydroxy or NR10R11; A represents â€”COâ€”, â€”CH2â€” or a bond; Q represents C1 to 4 alkylene; U, W and X independently represent carbon, optionally substituted by C1 to 4 alkyl, or nitrogen; V represents nitrogen, optionally substituted by C1 to 4 alkyl, or oxygen; Y represents C1 to 4 alkylene or â€”COâ€”; R5, R6, R7, R8, R9 independently represent hydrogen or C1 to 6 alkyl; R10 and R11 independently represent hydrogen, C2 to 6 unsaturated alkyl or C1 to 6 alkyl; each alkyl group being optionally further substituted by CO2R12, hydroxy, C1 to 6 alkoxy, CONH2, NR13R14, OCH2CH2OH, or a five or six membered saturated or unsaturated heterocyclic ring containing one or two heteroatoms selected from N, O and S; said ring optionally comprising one ring carbon atom that forms a carbonyl group; and said ring being optionally further substituted by C1 to 4 alkyl; or the group NR10R11 together represents a 4 to 8 membered saturated azacyclic ring system; said ring optionally comprising one additional ring heteroatom selected from N, O and S, said ring optionally comprising one ring carbon atom that forms a carbonyl group; and said ring being optionally further substituted by C1 to 6 alkyl, C1 to 6 hydroxyalkyl, hydroxy, CO2R15, CONH2, CHO or COCH3; R12 and R15 independently represent hydrogen or C1 to 4 alkyl; and R13 and R14 independently represent hydrogen, C1 to 4 alkyl or C1 to 4 alkanoyl; or a pharmaceutically acceptable salt or solvate thereof.