Patent ID: 8696759
Filing Date: 2014-04-15
Classification: A61L

Abstract:
1. A method for preparing a surface of an implant, comprising: exposing a metallic substrate to a first formulation to form a first chemically modified, texturized surface on the metallic substrate, the first texturized surface characterized by a first plurality of surface pits exhibiting a first average opening size in a range from about 200 nanometers to about 10 micrometers; and exposing the metallic substrate to a second formulation to form a second chemically modified, texturized surface on the metallic substrate, the second texturized surface characterized by a second plurality of surface pits exhibiting a second average opening size in a range from about 40 nanometers to about 200 nanometers, the surface capable of enhancing calcium phosphate formation on the surface relative to exposing the surface to only one of the first and second formulations wherein the metallic substrate comprises a cobalt-chromium alloy; wherein the surface after the exposing steps exhibits a layer having an enhanced chromium to cobalt ratio in at least a portion of the layer relative to a cobalt-chromium alloy not undergoing the exposing steps, the layer having a thickness less than about 25 angstroms.