Patent ID: 6069251
Filing Date: 2000-05-30
Classification: C07D

Abstract:
A compound of the formula: ##STR74## where R.sub.1 is aryl, heteroaryl, arylalkyl, cycloalkyl or naphthyl; unsubstituted or substituted by up to 3 substituents independently selected from hydrogen, halogen, trifluoromethyl, cyano, straight or branched chain lower alkyl having 1-6 carbon atoms, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms, or SO.sub.2 R.sub.9 where R.sub.9 is NH.sub.2 or NHCH.sub.3 ;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, lower alkyl, halogen, hydroxy lower alkyl, or phenyl unsubstituted or substituted by up to three substituents independently selected from hydrogen, halogen, trifluoromethyl, cyano, sulfonamido, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;R.sub.4 is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms, or R.sub.3 and R.sub.4 together represent --(CH2).sub.n .sbsb.1 -- where n.sub.1 is 2, 3 or 4; or R.sub.2 and R.sub.4 together represent --(CH.sub.2).sub.n.sbsb.2 -- where n.sub.2 is 2, 3 or 4.m is zero, one or twoR.sub.5 and R.sub.6 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, phenylalkyl or pyridylalkyl provided that m is zero and where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms, or R.sub.2 and R.sub.5 together represent --(CH.sub.2).sub.n.sbsb.3 -- where n.sub.3 is 2 or 3; orNR.sub.5 R.sub.6 together represent 2-(1,2,3,4-tetrahydroisoquinolinyl), either unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; orNR.sub.5 R.sub.6 represents ##STR75## where R.sub.7 is phenyl, benzyl or phenethyl with the phenyl ring unsubstituted or substituted with up to three substituents independently selected from hydrogen, halogen, trifluoromethyl, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; orNR.sub.5 R.sub.6 represents ##STR76## where p is 1, 2, or 3; and W is N and R.sub.8 is hydrogen, phenyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; orW is CH and R.sub.8 is unsubstituted or substituted phenyl, unsubstituted or substituted benzoyl or arylalkyl group where the phenyl ring may be substituted with up to three substituents independently selected from hydrogen, halogen, trifluoromethyl, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms.