Patent ID: 6746839
Filing Date: 2004-06-08
Classification: C12Q

Abstract:
A method for determining whether a subject has or is predisposed to developing an obstructive airway disease (OAD), comprising the step of detecting in a nucleic acid sample from the subject, an OAD associated allele, which is selected from the group consisting of: allele 2 of IL-13 (+2581); allele 2 of IL-1B (âˆ’511); allele 2 of IL-1B (+3954); or an allele in linkage disequilibrium with allele 2 of IL-1B (âˆ’511) or allele 2 of IL-1B (+3954) selected from the group consisting of: allele 4 of IL-1A (222/223); allele 4 of IL-1A (gz5/gz6); allele 1 of IL-1A (âˆ’889); allele 1 of (+3954); allele 3 of the gaat.p33330 marker; allele 3 of the Y31 marker; allele 2 of IL-1RN (+2018); allele 2 of IL-1RN (VNTR); allele 3 of IL-1A (222/223); allele 3 of IL-1A (gz5/gz6); allele 2 of IL-1A (âˆ’889); allele 1 of IL-1B (âˆ’511); allele 4 of the gaat.p33330 marker; allele 6 of the Y31 marker; allele 1 of IL-1RN (+2018); and allele 1 of IL-1RN (VNTR), wherein detection of the obstructive airway disease associated allele indicates that the subject has or is predisposed to the development of an obstructive airway disease.