Patent ID: 8349885
Filing Date: 2013-01-08
Classification: A61P,C07D

Abstract:
1. A method for preserving cells, tissues or organs using a composition comprising a compound of the following formula (1) or a pharmaceutically acceptable salt or stereoisomer thereof wherein X represents C or N, n is 0 or 1, and n is 1 when X is C and n is 0 when X is N, A represents a direct bond, C R1 represents hydrogen, —C(O)—B—X′—R7 or —(CR5R6) m is an integer of 0 to 4, each of R5 and R6 independently represents hydrogen or C B represents a direct bond, C X′ represents a direct bond, —C(O)—, —SO R7 represents hydrogen, C R2 represents —(CR5R6) D represents a direct bond or a 3˜10-membered heterocycle or heteroaryl, each of which optionally contains oxo and is optionally fused, and includes 1˜4 heteroatoms selected from N, O and S atoms, X″ represents a direct bond, —C(O)—, —C(O)O—, —NR5C(O)—, —C(O)NR5- or —O—, R8 represents hydrogen, halogen, C R3 represents hydrogen, halogen, cyano, nitro, aryl-R9 or (CR5R6) R9 represents hydrogen, halogen, C R4 represents —(CR5R6) Y represents a direct bond, —C(O)O— or —O—, and R10 represents hydrogen, nitro, halogen, C wherein each of said alkyl, alkoxy, aryl, cycloalkyl, heterocycle and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, nitrile, amino, C