Patent ID: 6753349
Filing Date: 2004-06-22
Classification: A61P,C07C

Abstract:
Method of preparing compounds containing at least one molecule of valproic acid salt and at least one molecule of valproic acid, comprising:selecting an amount of alkali metal carbonate, alkaline earth metal carbonate, alkali metal bicarbonate, alkaline earth metal bicarbonate, or combinations thereof; selecting an amount of valproic acid; combining the valproic acid directly with the selected amount of alkali metal carbonate, alkaline earth metal carbonate, alkali metal bicarbonate, alkaline earth metal bicarbonate, or combinations thereof to form a reaction mixture; reacting valproic acid directly with the selected amount of alkali metal carbonate, alkaline earth metal carbonate, alkali metal bicarbonate, alkaline earth metal bicarbonate, or combinations thereof in the absence of a solvent; and controlling a reaction temperature above the melting point of the valproic acid; wherein the valproic acid salt is an alkali metal or alkaline earth metal salt.