Patent ID: 7785578
Filing Date: 2010-08-31
Classification: A61K,A61P

Abstract:
1. A method for increasing the concentration of a therapeutic compound in an intermediate or a posterior region of a patient's eye, comprising: administering to the patient an effective amount of a therapeutic compound; and administering to the patient an α-agonist vasoconstrictor selected from the group consisting of, naphazoline, tetrahydrozoline, and a sympathomimetic amine selected from the group consisting of phenylethylamine, norepinephrine, dopamine, dobutamine, colterol, ethylnorepinephrine, isoproterenol, isoetharine, metaproterenol, terbutaline, metaraminol, tyramine, hydroxyamphetamine, ritrodrine, prenalterol, methoxamine, albuterol, amphetamine, methamphetamine, benzphetamine, ephedrine, phenylpropanolamine, methentermine, phentermine, fenfluramine, propylhexedrine, diethylpropion, phenmetrazine, phendimetrazine, and combinations thereof, wherein said α-agonist vasoconstrictor increases transport of the therapeutic compound across the sclera of an eye into the intermediate or posterior portion of the eye, and that also prolongs residence time of the therapeutic compound within the intermediate or posterior portions of the eye.