Patent ID: 7173149
Filing Date: 2007-02-06
Classification: C07C

Abstract:
1. A process for preparing alkynecarboxylic acids, comprising oxidizing an alkyne alcohol with a hypohalite in the presence of a nitroxyl compound at a pH of greater than 7 within a reaction mixture; and using from 2 to 5 mol equivalents of the hypohalite bsed on the number of functional groups to be oxidized, and continuously adding the alkyne alcohol and the hypohalite to the reaction mixture, wherein said nitroxyl compound is selected from the group consisting of (2,2,6,6-tetramethylpiperidine-1-oxyl also known as TEMPO, 4-hydroxy-TEMPO, 4-oxo-TEMPO, 4-amino-TEMPO, 4-acetamido-TEMPO, 4-benzyloxy-TEMPO, and 4-acetoxy-TEMPO, and wherein the reaction mixture is in two phases.