Patent ID: 8992948
Filing Date: 2015-03-31
Classification: A61K,A61P

Abstract:
1. A method for forming melatonin in a solid oral dosage form for buccal or sublingual delivery, which provides for increased oral absorption and bioavailability while shortening onset of melatonin action comprising: providing melatonin in an amount of about 0.01 mg to about 3 mg; providing a liquid polyethylene glycol (PEG) in an amount of about 0.03 mg to about 60 mg; dissolving said melatonin in said polyethylene glycol to form a melatonin-containing solution; providing a solid absorbent/adsorbent carrier in an amount of about 0.01 mg to about 120 mg; contacting said solid absorbent/adsorbent carrier with said melatonin-containing solution whereby said melatonin-containing solution is coated, absorbed or adsorbed onto said carrier; providing a solid water-soluble diluent; providing a disintegrant; providing a lubricant; forming a solid oral dosage form for buccal or sublingual administration; and administering said solid dosage form buccally or sublingually; wherein said solid dosage form disintegrates under the tongue within a time range between 30 seconds and five minutes; thereby providing increased oral absorption and bioavailability while shortening onset of melatonin action.