Patent ID: 8748442
Filing Date: 2014-06-10
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound according to Formula I, or a pharmaceutically acceptable salt thereof, wherein: ring B is a phenyl or a 6-membered heteroaryl ring, containing 1 or 2 nitrogen atoms in the ring; n is an integer selected from 0 to 3; each j each R each R X is selected from N, C-J o is an integer selected from 0 to 3; each J each R each R each R alternatively, two instances of R alternatively, one instance of R each R with the proviso that when X is C—H, each R each R alternatively, two instances of R alternatively, one instance of R or, alternatively, two J R ring C is a phenyl ring, a monocyclic 5 or 6-membered heteroaryl ring, a bicyclic 8 to 10-membered heteroaryl ring, a monocyclic 3 to 10-membered cycloaliphatic ring, or a monocyclic 4 to 10-membered heterocycle; wherein said monocyclic 5 or 6-membered heteroaryl ring, said bicyclic 8 to 10-membered heteroaryl ring, or said monocyclic 4 to 10-membered heterocycle contain between 1 and 4 heteroatoms selected from N, O or S; wherein said monocyclic 5 or 6-membered heteroaryl ring is not a 1,3,5-triazinyl ring; and wherein said phenyl, monocyclic 5 to 6-membered heteroaryl ring, bicyclic 8 to 10-membered heteroaryl ring, or monocyclic 4 to 10-membered heterocycle is optionally and independently substituted with up to 3 instances of J each J each R alternatively, two instances of R each R each R alternatively, two instances of R R with the proviso that when ring B is unsubstituted phenyl and ring D is unsubstituted pyrimidinyl (X is N and o is zero), R