Patent ID: 6534035
Filing Date: 2003-03-18
Classification: A61K,A61P

Abstract:
A method of detecting an actively forming blood clot in a mammal, comprising(a) administering to said mammal a diagnostically effective amount of a detectably labeled alpha-2 antiplasmin (&agr; 2AP) polypeptide, comprising the amino acid sequence of Xaa1 Gln Xaa2 Xaa3 Xaa4 Xaa5 Pro Leu Xaa6 Leu Leu Lys (SEQ ID NO:1), wherein Xaa1=Ala, Xaa2=Glu or Gln, Xaa3=Gln or Lys, Xaa4=Val or Leu, Xaa5=Pro or Ser, and Xaa6=Thr, Ser or Ala; and (b) determining by in vivo imaging localization of said polypeptide, wherein localization at a site of a vascular obstruction indicates an actively forming blood clot compared to a pre-existing blood clot at said site.