Patent ID: 6498146
Filing Date: 2002-12-24
Classification: A61K,C07H

Abstract:
A compound of the formula I or pharmaceutically acceptable salts or prodrugs thereof, wherein:R is C1-C10 alkyl, C3-C10 alkenyl, C3-C10 alkynyl, or C3-C10 cycloalkyl, wherein one or two carbons of said alkyl, cycloalkyl, alkenyl, alkynyl are optionally replaced by one or more heteroatoms selected from O, S and N, and are optionally substituted by one or more substituents selected from the group (hereinafter also referred to as â€œGroup Aâ€ ) consisting of: nitro; N3; CN; C1-C10 alkoxy; C1-C10alkanoyl; C1-C10 alkyl; C2-C10 alkenyl; C2-C10 alkynyl; C3-C10 cycloalkyl; 4 to 10 heterocyclic; â€”C(O)R10; â€”C(O)OR10; â€”NR10R11; â€”NHC(O)R10; â€”NHC(O)NR10 R11; â€”S(O)n, wherein n is 0, 1, or 2; â€”SO2R10; â€”SO2NR10R11; wherein each R1, R2, R31, and R4 is independently selected from the group consisting of H, C1-C12 alkyl, C3-C10 alkenyl, C3-C10 alkynyl, (CR8R9)mZ, m is an integer from 0 to 6; wherein one or two carbons of said alkyl, alkenyl, alkynyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N, and are optionally substituted by one or more substituents selected from Group A; or R2 and R3, together with the carbon to which they are attached, form a 3-10 membered ring; the ring carbons are optionally substituted by one or more heteroatoms selected from the group consisting of O, S and N; R5 is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, C3-C10 alkynyl, â€”CH2â€”CH&boxH;CHâ€”Z, (CR9R10)mZ; m is an integer from 1 to 6; wherein the alkyl, alkenyl and alkynyl can be substituted with one or more substituents selected from Group A; R6 is H, â€”C(O)O(C1-C18) alkyl or â€”C(O)(C1-C18) alkyl, wherein one or more carbons of said alkyl may be replaced by a heteroatom selected from O, S and N; R8 and R9 are independently selected from the group consisting of H, halo, C1-C6 alkyl; or R8 and R9, together with the carbon to which they are attached, form a 3 to 10 membered cyclic or heterocyclic di-radical; each R10 and R11 is individually H or C1-C12 alkyl, or aryl substituted C1-C12 alkyl, or heteroaryl substituted C1-C12 alkyl, wherein one or more carbons of either of said alkyl are optionally replaced by a heteroatom selected from O, S and N; each Z is independently a 4-10 membered heterocyclic or C6-C10 aryl, wherein said heterocyclic and aryl groups are optionally substituted by one or more substituents selected from Group A; T is absent or selected from the group consisting of: â€”C(O)â€”, â€”C(O)â€”Oâ€”, â€”CH2â€”, â€”C(S)â€”Sâ€”, â€”C(O)â€”NR10â€”; â€”S(O)nâ€”, where n is 0, 1, or 2, â€”S(O)nâ€”Oâ€”, wherein n is 0, 1, or 2, â€”P(O)(OR10)nâ€”, n is 0, 1, or 2, and â€”S(O)2â€”NR10â€”, Rt is selected from the group consisting of: C1-C6 alkyl, C3-C6 alkenyl, C3-C12 cycloalkyl, aryl, heteroaryl, heterocycloalkyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl groups are optionally substituted by one or more substituents selected from Group A.