Patent ID: 6193981
Filing Date: 2001-02-27
Classification: A61K,A61P,C07K,C12N

Abstract:
A composition comprising at least two variants of a peptide or polypeptide of the formula R1-Val-Asp-Pro-Y-Leu-Glu-Pro-R2 SEQ ID NO: 36,wherein each variant has a different amino acid residue at Y,wherein Y is selected from the group consisting of Arg, Lys, Ser and Asn;wherein R1 is selected from the group consisting of hydrogen, a lower alkyl, a lower alkanoyl, a sequence of between 1 to about 5 additional amino acids, and a sequence of 1 to about 5 amino acids with at least one of said additional amino acids being substituted with a lower alkyl or lower alkanoyl;wherein R2 is selected from the group consisting of a free hydroxyl, an amide, a sequence of one to about 14 additional amino acids, and a sequence of 1 to about 14 amino acids with at least one of said additional amino acids being substituted with an amide.