Patent ID: 6076528
Filing Date: 2000-06-20
Classification: A61B

Abstract:
A method for treating a human patient who is preparing to undergo coronary artery bypass grafting surgery in an operation which requires circulatory bypass of the patient's heart, comprising intravenously injecting into the patient, prior to commencing circulatory bypass of the heart, a liquid formulation containing fructose-1,6-diphosphate or a pharmacologically acceptable salt thereof, in a manner which causes the fructose-1,6-diphosphate to permeate into heart muscle tissue while the heart is still beating, wherein:(i) the fructose-1,6-diphosphate is injected into the patient in a therapeutically effective quantity which reduces damage to heart tissue during surgery which requires circulatory bypass of a patient's heart; and,(ii) the fructose-1,6-diphosphate is injected into the patient in a manner which does not increase a risk of atrial fibrillation.