Patent ID: 7893256
Filing Date: 2011-02-22
Classification: A61K,A61P,C07D

Abstract:
1. A process for preparing a compound of formula I: wherein R R R R R R or R wherein R R R wherein d, e, f, g, h and i are each independently selected from 0 and 1; R A Q is selected from a bond, —O—, —C(O)O—, —OC(O)—, —S—, —S(O)—, —S(O) Q A provided that the number of contiguous atoms in the shortest chain between the two nitrogen atoms to which R R R each of R each of R or a salt or stereoisomer thereof; the process comprising: (a) reacting a compound of formula 1: wherein R wherein X (b) reacting a compound of formula 3: wherein P wherein X (c) coupling a compound of formula 5: or a salt or protected derivative thereof; with a compound of formula 6: wherein X (d) for a compound of formula I wherein R or a hydrate thereof (e.g., a glyoxal), wherein P 9 represents hydrogen or a hydroxy-protecting group, in the presence of a reducing agent; (e) reacting a compound of formula 1 with a compound of formula 8: or a salt or hydrate or protected derivative thereof, in the presence of a reducing agent, wherein P (f) reacting a compound of formula 9: wherein X wherein P (g) reacting a compound of formula 11: with a reducing agent; wherein P (h) reacting a compound of formula 12: or a salt or hydrate or protected derivative thereof; wherein R and then removing any protecting groups to provide a compound of formula I or a salt or stereoisomer thereof.