Patent ID: 6057341
Filing Date: 2000-05-02
Classification: A61P,C07D

Abstract:
A compound of general formula (I): ##STR10## in which, Ar is selected from the group consisting of the following radicals: ##STR11## R.sub.7 and R.sub.8 are defined below, X is a radical or bonds selected from the group consisting of formula (a)-(g), which can be read in both directions: ##STR12## R.sub.1 represents (i) a hydrogen atom,(ii) the --CH.sub.3 radical,(iii) the --O--R.sub.3 radical,(iv) the --CH.sub.2 --O--R.sub.3 radical,(v) the --O(CH.sub.2).sub.m --(CO).sub.n --R.sub.4 radical,(vi) the --CO--R.sub.5 radical(vii) the --CO--O--R radicalR.sub.2 is a hydrogen atom or a --(CH.sub.2).sub.n --O--R.sub.3 radical,m and n and R.sub.3 to R.sub.6 are defined below,W is an oxygen atom, a S(O).sub.p radical or a N--R.sub.7 radical, R.sub.7 is defined below,R.sub.3 is a hydrogen atom, a lower alkyl radical or a --CO--R.sub.9 radical, R.sub.9 is defined below,R.sub.4 is a lower alkyl radical or a heterocycle,R.sub.5 is a hydrogen atom, a lower alkyl radical or an --N(r',r"") radical, in which r' and r"", which are identical or different, are selected from the group consisting of a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid, and a peptide or sugar residue or alternatively r' and r"", taken together, form a heterocycle,R.sub.6 is selected from the group consisting of a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, an alkenyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical, and a sugar, amino acid or peptide residue,R.sub.7 is a hydrogen atom or a lower alkyl radical,R.sub.8 is a --(CH.sub.2).sub.n --O--R.sub.3 radical, wherein R.sub.3 is defined above,R.sub.9 is a hydrogen atom, a lower (lacuna) radical or an aryl radical,m is an integer equal to 1, 2 or 3,n is an integer equal to 0 or 1, and the optical and geometrical isomers of the said pure compounds, mixtures thereof and pharmaceutically acceptable salts thereof.