Patent ID: 6420572
Filing Date: 2002-07-16
Classification: A61K,A61P,C07D,C07H

Abstract:
A process for the preparation of a protected proanthocyanidin which comprises the steps of:(a) protecting each phenolic hydroxyl group of a first and a second phenolic monomer selected from the group consisting of a apigeniflavan, luteoliflavan, tricetichinflavan, afzelechin, guibourtinidol, fisetinidol, robinetinidol, oritin, and prosopin to form first and second protected monomers; (b) oxidizing the 4-position of the first protected monomer to form a protected monomer derivatized at the 4-position with a C2-C6 alkoxy group having a terminal hydroxy group; (c) coupling the derivatized, protected monomer with the second protected monomer to form a protected dimer; and (d) optionally coupling additional protected phenolic monomers to form a protected proanthocyanidin oligomer.