Patent ID: 6566491
Filing Date: 2003-05-20
Classification: A61K,A61P,C07K,Y02P

Abstract:
A compound of formula IR1â€”Q1â€”Xâ€”Q2â€”R2â€ƒâ€ƒI in whichQ1, Q2 are, in each case independently of each other, either absent or â€”NHâ€”(CH2)nâ€”COâ€”, R1, R2 are, in each case independently of each other, either absent or cyclo-(Arg-Gly-Asp-Z), where Z is bonded in the side chain to Q1 or Q2 or, if Q1 and/or Q2 is/are absent, to X, and where at least one of the radicals R1 or R2 must always be present,X is â€”COâ€”R18â€”COâ€”, and if R1â€”Q1â€” or R2â€”Q2â€” is absent, R10, R13, R16 or a fluorescent dye residue which is linked by way of a â€”CONHâ€”, â€”NHâ€”C(&boxH;S)â€”NHâ€” bond, or is salicyloyl, Z is Phe-Lys, where the said amino acids can also be derivatized to N-methyl, N-ethyl, N-propyl, N-benzyl or C&agr;-methyl derivatives and the amino acid residues are linked to each other, in peptide manner, by way of the &agr;-amino and &agr;-carboxyl groups, and R10 is alkanoyl having 1-8 carbon atoms which is substituted once by SR11, R11 is trityl, R13 is aroyl having 7-11 carbon atoms which is unsubsituted, R16 is aralkanoyl having 7-10 carbon atoms which is unsubstituted, R18 is absent, or is R19, R19 is alkylene having 1-6 carbon atoms, and n is 1, 2, 3, 4 or 5, where, provided that the residues are residues of optically active amino acids and amino acid derivatives, both the D and the L forms are included, and the salts thereof.