Patent ID: 6235305
Filing Date: 2001-05-22
Classification: A61K,C07D

Abstract:
A composition comprising a compound having at least one lipase inhibitor moiety which is bound to a non-absorbable biocompatible, pharmaceutically acceptable polysaccharide polymer support by at least one chemical bond which is substantially non-clevable by the digestive system of a dog, cat, non-human primate or a human, whereby the lipase inhibitor is essentially non-absorbable, wherein:(a) the lipase inhibitor moiety is bound via a derivatized nitrogen, acid or alcohol group to a divalent bridging group, which is in turn bound to the polymer support by a derivatized alcohol, acid or amino group on the polymer support;(b) the divalent bridging group is a member selected from the group consisting of a straight or branched chain alkylene bridging group, an alkenyl bridging group, an alkynyl bridging group, a monoacyl group, and a diacyl group; and(c) the lipase inhibitor moiety is a member selected from the group consisting of orlistat, esterastin, 3,5-hydroxy-2-hexadeca-7,10-dienoic 1,3-lactone, 3,5-dihydroxy-2-hexylhexadeca-7,10-dienoic 1,3-lactone, and3,5-di-hydroxy-2-hexylhexadecanoic 1,3-lactone.