Patent ID: 6288064
Filing Date: 2001-09-11
Classification: A61P,C07D

Abstract:
A method for treating erectile dysfunction which comprises administering an effective amount of a fused pyridazine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, to a patient in need thereof: ##STR8##wherein the ring C represents an unsaturated 5 or 6 membered ring optionally having one heteroatom;n is 0 or an integer of from 1 to 4;R.sup.1 represents a halogen, an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted cycloalkyl, a nitro, a cyano, a group represented by the formula --NR.sup.2 R.sup.3,wherein R.sup.2 and R.sup.3 are the same as or different from each other and represent a hydrogen, an optionally substituted lower alkyl, an acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl, or R.sup.2 and R.sup.3 together with the nitrogen atom to which they are bonded may form a ring, and the ring may be substituted,a group represented by the formula --O--R.sup.9,wherein R.sup.9 represents a hydrogen, an optionally substituted lower alkyl, acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl,a group represented by the formula --S--R.sup.10,wherein R.sup.10 represents a hydrogen, an optionally substituted lower alkyl, acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl,a group represented by the formula: ##STR9##wherein R.sup.11 represents a hydrogen, a lower alkyl or an amino; and m is 0 or an integer of 1 or 2,or an optionally protected carboxy, provided that when n is 2 to 4, then R.sup.1 s may independently represent the above substituents;A represents a hydrogen, a halogen, a group represented by the formula --NR.sup.4 R.sup.5,wherein R.sup.4 and R.sup.5 are the same as or different from each other and represent a hydrogen, an optionally substituted lower alkyl, an acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl, or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are bonded may form a ring, and the ring may be substituted, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl;X represents a group represented by the formula --NR.sup.6 --,wherein R.sup.6 represents a hydrogen, an optionally substituted lower alkyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl or a group represented by the formula --N.dbd.;Y represents a group represented by the formula --CO-- or --C(B).dbd.,wherein B represents a hydrogen, a halogen, a group represented by the formula --NR.sup.7 R.sup.8,wherein R.sup.7 and R.sup.8 are the same as or different from each other and represent a hydrogen, an optionally substituted lower alkyl, an acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl, or R.sup.7 and R.sup.8 together with the nitrogen atom to which they are bonded may form a ring, and the ring may be substituted,a group represented by the formula --O--R.sup.12,wherein R.sup.12 represents a hydrogen, an optionally substituted lower alkyl, an acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl,a group represented by the formula --S--R.sup.13,wherein R.sup.13 represents a hydrogen, an optionally substituted lower alkyl, an acyl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl,an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted arylalkyl or an optionally substituted heteroarylalkyl; and ##STR10##represents a double or single bond;provided that when C is a benzene ring, then the case where n is 0 is excluded.