Patent ID: 6288042
Filing Date: 2001-09-11
Classification: A61K,C07H,C12N

Abstract:
An oligonucleotide having the general sequence ##STR1##wherein N.sub.17 is omitted, is abasic, or is selected from the group consisting of a thymidylate (T) moiety and a 5-propynyl-2'-deoxyuridylate (C-5 propynyl-dU) moiety;N.sub.2 is abasic, or is selected from the group consisting of T, C-5 propynyl-dU, 5-bromo-2'-deoxyuridylate(C-5 bromo-dU), and 5-iodo-2'-deoxyuridylate(C-5 iodo-dU) moieties;N.sub.5 is abasic, or is selected from the group consisting of T, C-5 propynyl-dU, C-5 bromo-dU, and C-5 iodo-dU;N.sub.9 is abasic, or is selected from the group consisting of T, C-5 propynyl-dU, C-5 bromo-dU, and C-5 iodo-dU moieties;N.sub.13 is abasic, or is selected from the group consisting of T, C-5 propynol-dU, C-5 bromo-dU, and C-5 iodo-dU moieties;optionally modified by at least one phosphorothioate internucleoside linkage;optionally modified at the 5' terminus by a moiety chosen from the group consisting of a radical derived from propylamine, polyamine, poly-L-lysine, cholesterol, a C.sub.2-24 fatty acid or vitamin E; andoptionally modified at the 3' terminus by a moiety chosen from the group consisting of a radical derived from propylamine, polyamine, poly-L-lysine, cholesterol, a C.sub.2-24 fatty acid or vitamin E,provided however that N.sub.2, N.sub.5, N.sub.9, N.sub.13 and N.sub.17 are not together T.