Patent ID: 6291649
Filing Date: 2001-09-18
Classification: A61K,A61P,C07K,Y10S

Abstract:
An isolated antibody which binds an isolated antigen which is an adhesin polypeptide native to a pilus of a pathogenic pilus-forming bacterium, capable of adhering to a mammalian cell, which pilus binds to a cell surface receptor of a mammalian cell by means of an adhesin polypeptide which is a minor molecular component of the pilus,which adhesin polypeptide is distinct from the major molecular component (pilin) of the pilus,said adhesin polypeptide comprises an antigenic determinant which is distinct from the antigenic determinants of the major molecular component of the pilus,said adhesin polypeptide not comprising pilin or pilin-specific antigenic determinants.