Patent ID: 8048450
Filing Date: 2011-11-01
Classification: A61K,Y10S

Abstract:
1. An aqueous dispersion of hydrogel interpenetrating polymer network of mono-dispersed nanoparticles, comprising: interpenetrating polymer network nanoparticles, wherein each IPN nanoparticle comprises a first polymer network interpenetrating a second polymer network; and an aqueous medium; wherein, the first polymer comprises poly(N-isopropylacrylamide) or hydroxypropylcellulose, and the second polymer comprises poly(acrylic acid); wherein, the IPN mono-dispersed nanoparticles are substantially free of a core-shell polymer configuration; and the aqueous dispersion of hydrogel nanoparticles can undergo a reversible gelation in response to a change in stimulus applied thereon; and wherein, the aqueous dispersion exhibits a change in particle size of less than 30 nm when the aqueous dispersion is heated from below a volume phase transition temperature to above a volume phase transition temperature at a concentration of 2.88×10