Patent ID: 6010691
Filing Date: 2000-01-04
Classification: A61K,Y10S

Abstract:
A method for enhancing permeation of a topically administered physiologically active substance applied to the epithelium of a host, wherein the method comprises the following steps:(1) applying to the epithelium of the host a composition comprising from about 0.01 to 25 weight percent of a compound selected from the group consisting of stearylamines, transvaccenic acid and combinations thereof, and(2) applying to the epithelium of the host a physiologically active substance selected from the group consisting of antimicrobial, anti-inflammatory, anti-neoplastic, antioxidant, analgesic, anesthetic, antiepileptic, antihypertensive, neuroleptic, antiarrhythmic, nutritional and vasodilatory agents; antiandrogens; antihistamines; antitussives; hormones; and cytokines,whereby enhanced permeation of the physiologically active substance through the epithelium is caused.