Patent ID: 8907045
Filing Date: 2014-12-09
Classification: A61L,C08G,C09J

Abstract:
1. A block co-polymer of Formula I wherein, R is H or alkyl; Y is —O—, —N(H)—, or —NC(O)alkylene-; L is a bond, an alkylene, —O—, —Oalkylene-, —N(R′)—, —N(R′)alkylene-, —C(O)—, —C(O)alkylene-, —C(O)N(R′)—, —C(O)N(R′)alkylene-, —C(O)O—, —C(O)Oalkylene-, —N(R′)C(O)O—, —N(R′)C(O)Oalkylene-, —OC(O)N(R′)alkylene-, —N(R′)C(O)N(R′)—, or —N(R′)C(O)N(R′)alkylene-; Q is a mono- or divalent radical of an amino acid side chain selected from a glutamic acid side chain, an aspartic acid side chain, a tyrosine side chain, a serine side chain, a threonine side chain, a lysine side chain, an ornithine side chain, a histidine side chain, an arginine side chain, a hydroxyarginine side chain, or an N-(3-hydroxypropyl)aspartamide side chain; X is independently and at each occurrence a bond, an alkylene, —O—, —Oalkylene-, —N(R′)—, —N(R′)alkylene-, —C(O)—, —C(O)alkylene-, —C(O)N(R′)—, —C(O)N(R′)alkylene-, —C(O)O—, —C(O)Oalkylene-, —N(R′)C(O)O—, —N(R′)C(O)Oalkylene-, —OC(O)N(R′)alkylene-, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)alkylene-, —N(R′)alkyleneN(R′)—, —N(R′)alkyleneC(O)N(R′)—, —N(R′)alkyleneN(R′)C(═NR′)N(R′)—, —N(R′)alkyleneN(R′)C(═NR′)N(R′)O—, 3-oxylpyrrolidine-1,3-diyl, —C(O)alkyleneN(R′)—, —C(O)alkyleneC(O)N(R′)—, —C(O)alkyleneN(R′)C(═NR′)N(R′)—, —C(O)alkyleneN(R′)C(═NR′)N(R′)O—, or when taken together with Z is null; Z is independently and at each occurrence selected from the group consisting of H, alkyl, and a group of Formula II  or when taken together with X is null, wherein at least one occurrence of Z is the group of Formula II; Z R′ is independently and at each occurrence H or alkyl; m is an integer from 0 to about 2000; and p is an integer from 1 to about 7000.