Patent ID: 7700709
Filing Date: 2010-04-20
Classification: A61K,A61P,C08G

Abstract:
1. A polymeric derivative of a cytidine antimetabolite, comprising a structure in which an amino group of a cytidine antimetabolite is amide-bonded to a carboxyl group in a side chain of a polymeric compound composed of a polyethylene glycol moiety and a polyglutamic acid chain moiety, wherein the derivative is a compound represented by general formula (1): wherein R represents a hydrogen atom or a C1 to C6 alkyl group; A represents a hydrogen atom, a C1 to C6 acyl group, or a C1 to C6 alkoxycarbonyl group; m represents 3 to 200 as a mean value; n represents 5 to 2,000 as a mean value; X represents a cytidine antimetabolite residue, a hydroxyl group, or a hydrophobic substituent, wherein the proportion of the cytidine antimetabolite residue in X is 3 to 100% of m, the proportion of the hydroxyl group in X is 0 to 95% of m and the proportion of the hydrophobic substituent in X is 0 to 80% of m.