Patent ID: 7094808
Filing Date: 2006-08-22
Classification: A01N,A61K,C07C,C07D

Abstract:
1. An article of manufacture comprising packaging material and a pharmaceutical agent contained within said packaging material, wherein said pharmaceutical agent is effective for the treatment of a subject suffering from neoplasm, and wherein said packaging material comprises a label which indicates that said pharmaceutical agent can be used for treating neoplasm, and wherein said pharmaceutical agent is a polyamine having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R N a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between said nitrogen atoms such that said polyamine: (i) is capable of uptake by a target cell upon administration of said polyamine to a human or non-human animal; and (ii) upon uptake by said target cell, competitively binds via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intra-cellular natural polyamines in the target cell; said polyamine, upon binding to said biological counter-anion in the cell, functions in a manner biologically different than said intracellular polyamines, said polyamine not occurring in nature.