Patent ID: 8877190
Filing Date: 2014-11-04
Classification: A61P,C07K,G01N

Abstract:
1. A method for treating amyloidosis in a patient in need of said treatment comprising administering to said patient an isolated antibody having a higher affinity to Aβ(1-42) globulomer than to at least one amyloid beta protein selected from the group consisting of a) Aβ(1-42) peptide present in cerebrospinal fluid (CSF) and b) Aβ(1-40) peptide present in CSF in an amount sufficient to effect said treatment, wherein said antibody comprises: a variable heavy chain region (VH) comprising the sequences of SEQ ID NOs: 9-11 and a variable light chain region (VL) comprising the sequences of SEQ ID NOs: 12-14: a VH comprising the sequences of SEQ ID NOs: 15-17 and a VL comprising the sequences of SEQ ID NOs: 18-20; a VH comprising the sequence of SEQ ID NO: 5; a VL comprising the sequence of SEQ ID NO: 6; a VH comprising the sequence of SEQ ID NO: 7; or a VL comprising the sequence of SEQ ID NO: 8.