Patent ID: 8946129
Filing Date: 2015-02-03
Classification: C12Q,G01N,Y10T

Abstract:
1. A set of mass labels, each mass label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalisation moiety, wherein when the linker is cleaved by dissociation in a mass spectrometer, each mass label is adapted to dissociate to form the mass marker moiety and the mass normalization moiety, each mass label in the set having a common mass; wherein the set comprises a plurality of groups of mass labels, the mass of the mass marker moiety being the same for mass labels within a group, the mass of the mass marker moiety being different between groups; the mass marker moiety is capable of fragmentation by collision induced dissociation in the mass spectrometer into two or more fragments; and the mass of at least one fragment of the mass marker moiety differs between mass labels within a group such that each mass marker moiety of the mass labels within a group is distinguishable from one another by mass spectrometry, wherein one or more mass labels in the set comprises one or more isotopic labels and wherein the isotopic label comprises