Patent ID: 6069149
Filing Date: 2000-05-30
Classification: A61P,C07D

Abstract:
An amide derivative represented by the formula (I) and its pharmaceutically acceptable acid addition salt: ##STR89## wherein the formula (I), R.sub.1 and R.sub.2 are independently a branched or unbranched C.sub.1-6 alkyl;X is a member selected from the group consisting of --O--, --NR.sub.4 --, --CR.sub.5 .dbd.CR.sub.6, and S(O).sub.p ; wherein R.sub.4 is at least a member selected from ##STR90## pyridyl, and a branched or unbranched C.sub.1-8 alkyl; R.sub.15 is a member selected from the group consisting of hydrogen, a C.sub.1-8 alkyl, hydroxyl, hydroxycarbonyl, a C.sub.1-8 alkoxy, a C.sub.1-8 alkoxycarbonyl, and a halogen; R.sub.5 and R.sub.6 are independently hydrogen and phenyl; and p is an integer of 0 to 2;Y is selected from --CR.sub.7 R.sub.8 -- and phenylene; wherein R.sub.7 is at least a member selected from ##STR91## pyridyl, and a branched or unbranched C.sub.1-8 alkyl; R.sub.8 is hydrogen or phenyl; and R.sub.15 is a member selected from the group consisting of hydrogen, a C.sub.1-8 alkyl, hydroxyl, hydroxycarbonyl, a C.sub.1-8 alkoxy, a C.sub.1-8 alkoxycarbonyl, and a halogen;Z is selected from ##STR92## wherein R.sub.12 and R.sub.13 are independently a member selected from the group consisting of hydrogen, a C.sub.1-8 alkyl, hydroxyl, hydrocarbonyl, a C.sub.1-8 alkoxy, a C.sub.1-8 alkoxycarbonyl and a halogen;h, j and l are an integer of 0 or 1;m is an integer of 0 to 5;n is an integer of 2 to 12;g, i and k are an integer of 0 to 6; andR.sub.3 is a member selected from the group consisting of hydrogen, phenyl, a branched or unbranched C.sub.1-8 alkyl and --(CH.sub.2).sub.r R.sub.14 ; wherein r is an integer of 1 to 8, and R.sub.14 is a member selected from the group consisting of phenyl, phenoxy, benzyloxy, a C.sub.1-8 alkoxy, amino, a C.sub.1-8 alkylamino, hydroxycarbonyl and a C.sub.1-8 alkoxycarbonyl.