Patent ID: 6066634
Filing Date: 2000-05-23
Classification: C07D

Abstract:
A method of inhibiting cGMP specific phosphodiesterase activity comprising exposing a cGMP-specific phosphodiesterase to compound of the formula: ##STR6## wherein R.sub.1 is independently selected in each instance from the group consisting of hydrogen, halogen, lower alkyl, loweralkoxy, amino, loweralkylamino, di-loweralkylamino, loweralkylmercapto, loweralkyl sulfonyl, cyano, carboxamide, carboxylic acid, mercapto, sulfonic acid, xanthate and hydroxy;R.sub.2 is selected from the group consisting of hydrogen and lower alkyl;R.sub.3 is selected from the group consisting of hydrogen, halogen, amino, hydroxy, lower alkyl amino, and di-loweralkylamino;R.sub.4 is hydrogen, or R.sub.3 and R.sub.4 together are oxygen;R.sub.5 and R.sub.6 are independently selected from the group consisting of hydrogen, lower alkyl, hydroxy-substituted lower alkyl, amino lower alkyl, lower alkylamino-lower alkyl, lower alkyl amino di-lower alkyl, lower alkyl nitrile, --CO.sub.2 H, --C(O)NH.sub.2, and a C.sub.2 to C.sub.6 amino acid;R.sub.7 is independently selected in each instance from the group consisting of hydrogen, amino lower alkyl, lower alkoxy, lower alkyl, hydroxy, amino, lower alkyl amino, di-lower alkyl amino, amino lower alkyl, halogen, --CO.sub.2 H, --SO.sub.3 H, --SO.sub.2 NH.sub.2, and --SO.sub.2 (lower alkyl);m and n are integers from 0 to 3 independently selected from one another;Y is selected from the group consisting of quinolinyl, isoquinolinyl, pyridinyl, pyrinidinyl, pyrazinyl, imidazolyl, indolyl, benzimidazolyl, triazinyl, tetrazolyl, thiophenyl, furanyl, thiazolyl, pyrazolyl, or pyrrolyl, or subsituted variants thereof wherein the substituents are one or two selected from the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, --SO.sub.2 (lower alkyl) and --SO.sub.2 NH.sub.2 ; andpharmaceutically acceptable salts thereof.