Patent ID: 9027356
Filing Date: 2015-05-12
Classification: A01N,F25D,Y10T

Abstract:
1. A method for monitoring the freezing of a biopharmaceutical material contained in a biocontainer, the method comprising the steps of: providing a sterilized biocontainer of a predetermined volumetric capacity comprising an indicator to indicate whether said biopharmaceutical material was properly frozen, a storage element, and a sensor attachment mechanism affixed to opposite edges of said biocontainer, disposed within said biocontainer and passing through the geometric center of said biocontainer, said sensor attachment mechanism comprising a sealed enclosure holding a wireless temperature sensor, said wireless temperature sensor positioned at or about the geometric center of said biocontainer, wherein said storage element is in communication with said temperature sensor; filling said biocontainer to its volumetric capacity with said biopharmaceutical material; placing said biocontainer in a cryofreezer, thereby to freeze said biopharmaceutical material contained therein; using said sensor to monitor the temperature of said biopharmaceutical material at said geometric center; storing data from said sensor in said storage element; allowing said biopharmaceutical material to freeze; providing a processing unit in communication with said temperature sensor, said indicator, and said storage element; comparing, by said processing unit, temperature data from said wireless temperature sensor to predetermined values to determine whether, once frozen, said biopharmaceutical material was properly frozen; actuating said indicator by said processing unit to indicate the result of said determination of whether said biopharmaceutical material was properly frozen.