Patent ID: 6750348
Filing Date: 2004-06-15
Classification: A61K,A61P,C07D

Abstract:
A compound according to Formula I: wherein, W is a nitrogen atom and Y is void, or W is a carbon atom and Y=H;R1 to R7 may be the same or different and are independently hydrogen or straight, branched or cyclic C1-6 alkyl; R8 is an optionally substituted heterocyclic group or an optionally substituted aromatic group Ar is an aromatic or heteroaromatic ring optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and nâ€² are independently, 0-2; X is a group of the formula: wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted nitrogen atom and wherein any heteroatom in addition to P in ring A is N; wherein Ring B is an optionally substituted 5 to 7-membered ring; wherein Ring A or Ring B is bound to group W from any position through group V; wherein V is a chemical bond or V is a (CH2)nâ€³ group (where nâ€³=1-2), or V is a C&boxH;O group; and wherein Z is selected from the group consisting of: a hydrogen atom; an optionally substituted C1-6 alkyl group; an optionally substituted aromatic or heterocyclic group; an optionally substituted amino group; an optionally substituted C1-6 alkylamino or C3-7 cycloalkylamino group; and a substituted carbonyl group; or the pharmaceutically acceptable acid addition salts thereof; wherein said compound may be in any stereoisomeric form or present as a mixture of stereoisomeric forms thereof; wherein Ring B is selected from the group consisting of: benzene and a 5 to 7-membered cycloalkyl ring; and the optionally substituted forms thereof.