Patent ID: 7538197
Filing Date: 2009-05-26
Classification: A61K,C07K

Abstract:
1. An isolated neuregulin-β isoform, having an isoelectric point (pI) in the range from about pH 4.3 to 5.0, wherein said neuregulin-β isoform has an apparent molecular mass of about 32 kd as determined using SDS-PAGE and comprises amino acids 88-94 according to SEQ ID NO:4, and wherein said isolated neuregulin-β isoform is obtainable from mammalian hippocampal cells using isoelectric focusing employing immobilized, nonlinear pH gradients from 3 to 10 and linear gradients of from 4 to 7 as a first dimension and SDS-PAGE (12% acrylamide) as a second dimension in two dimensional PAGE.