Patent ID: 6828316
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound represented by formula (1): wherein:A is a phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl group, any of which may be substituted; B is a group of â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”(CH&boxH;CH)2â€”, â€”CH&boxH;CHâ€”Câ‰¡Câ€” or â€”Câ‰¡Câ€”CH&boxH;CHâ€”, or a divalent residue of benzene, pyridine, pyrimidine or pyrazine, any of which may be substituted; and W is diazepine as shown in the following formula, where n is 3 and X is â€”CHY1â€”CHY2â€” or n is 2 and X is â€”CH2â€”CHY3â€”CH2â€”wherein Y1, Y2 and Y3 are each independently selected from the group consisting of: a hydrogen atom, â€”COOR1, wherein R1 is a hydrogen atom or a lower alkyl group, â€”CON(R2)R3, wherein R2 and R3 are each independently selected from the group consisting of a hydrogen atom, a hydroxyl group, and a lower alkyl group, â€”CH2N(R4)R5, wherein R4 and R5 are each independently a hydrogen atom or a lower alkyl group, or R4 and R5 may form, together with the adjacent nitrogen atom, a heterocyclic ring which may further have an oxygen, nitrogen or sulfur atom, and â€”CH2â€”Sâ€”R6, wherein R6 is a lower alkyl, phenyl or pyridyl group; or a salt thereof, or a hydrate or solvate thereof.