Patent ID: 6320062
Filing Date: 2001-11-20
Classification: A61P,C07C

Abstract:
A compound according to formula (I): ##STR14##wherein:R.sup.1 is (CH.sub.2).sub.n CO.sub.2 R, (CH.sub.2).sub.n CONR.sup.2 R.sup.3, (CH.sub.2).sub.n CH.sub.2 OR.sup.4, (CH.sub.2).sub.n CH.sub.2 NR.sup.5 R.sup.6, (CH.sub.2).sub.n CH.sub.2 N.sub.3, (CH.sub.2).sub.n CH.sub.2 Hal, (CH.sub.2).sub.n CH.sub.2 NO.sub.2, (CH.sub.2).sub.n CH.sub.2 SR.sup.20, (CH.sub.2).sub.n COSR.sup.21 or (CH.sub.2).sub.n -2,3,4,5-tetrazol-1-yl, wherein:R is H or CO.sub.2 R forms a pharmaceutically acceptable salt or a pharmaceutically acceptable ester;NR.sup.2 R.sup.3 and NR.sup.5 R.sup.6 are the same or different and comprise a free or functionally modified amino group;OR.sup.4 comprises a free or functionally modified hydroxy group;Hal is F, Cl, Br or I;SR.sup.20 comprises a free or functionally modified thiol group;R.sup.21 is H or COSR.sup.21 forms a pharmaceutically acceptable salt or a pharmaceutically acceptable thioester;n is 0 or 2;A, B, C and D is C.sub.1 -C.sub.5 alkyl, alkenyl, or alkynyl or a C.sub.3 -C.sub.5 allenyl group;Y is ##STR15##whereinR.sup.8 is CH.sub.3, andX is CH.sub.2, CH(CH.sub.3) or C(CH.sub.3).sub.2 ; orY is CH.sub.2, CH(CH.sub.3) or C(CH.sub.3).sub.2, andX is ##STR16##whereinR.sup.8 is CH.sub.3, with the proviso that Y cannot be CH.sub.2 when X is ##STR17##andR.sup.7 O comprises a free or functionally modified hydroxy group.