Patent ID: 7358356
Filing Date: 2008-04-15
Classification: C07D

Abstract:
1. A method for preparing a β-lactam compound, which comprises the following steps: reacting a compound of Formula (2), wherein A represents a condensed heterocyclic group having a β-lactam ring structure, and M represents a hydrogen atom or a metal atom, in a polar organic solvent, with a 4-halogenomethyldioxolenone compound of Formula (3),  wherein R dehydrating a polar organic solvent solution obtained as the reaction solution or obtained by working up the reaction solution, to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating two or more cycles of adding a polar organic solvent to the polar organic solvent solution and then distilling off water together with the polar organic solvent wherein the polar organic solvent further contains an iodine compound.