Patent ID: 7652045
Filing Date: 2010-01-26
Classification: A61P,C07D

Abstract:
1. A method for treating a condition or disorder associated with modulation of peroxisome proliferator-activated receptor delta (PPARδ) transactivation activity, wherein the condition or disorder is selected from the group consisting of dyslipidemia, hyperglycemia, hyperlipidemia, hypercholesterolemia, hyperlipoproteinemia, obesity, syndrome X, atherosclerosis, hyperphagia, ischemic disease, Alzheimer's disease, osteoporosis, Basedow's disease, adrenal cortical dystrophy, and cancer, wherein cancer is a lung cancer, mammary cancer, colon cancer, ovary cancer, or cancer of great intestine; said method comprising administering to a patient in need thereof a compound of the formula (I): or a salt thereof, wherein: R R A is oxygen or sulfur; X is a C Y is C(═O), CH═CH, or C(═CH each of R B is CH; Z is oxygen or sulfur; each of R R provided that at least one of R 3 , R 4 and R 5 is not hydrogen.