Patent ID: 9034329
Filing Date: 2015-05-19
Classification: A61K,C07K,C12N

Abstract:
1. A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome complex comprising: (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome that does not comprise maleimido-phenylbutyrate-lipid (MPB-lipid) to form a cationic immunoliposome, wherein said antibody or antibody fragment is complexed with said cationic liposome but is not chemically conjugated to said cationic liposome and wherein said antibody or antibody fragment does not comprise a lipid tag; and (c) mixing said cationic immunoliposome with an siRNA to form said antibody- or antibody fragment-targeted-cationic immunoliposome complex, wherein the cationic immunoliposome complex is 50-400 nm in size.