Patent ID: 8354544
Filing Date: 2013-01-15
Classification: C07D,C07F

Abstract:
1. A process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole represented by the following formula (II): in which R R R R in which a) a 1-benzyl-3-halogeno-1H-indazole of formula (III): in which X is a halogen atom selected from iodine and bromine, is caused to react with an alkyl magnesium halide of formula RMgX′ where R is an alkyl group having 1 to 6 carbon atoms and X′ is a halogen atom selected from bromine and chlorine, preferably chlorine, to form intermediate compound (IV): b) the said intermediate compound (IV) is caused to react with a carbonyl compound of formula R b′) the said intermediate compound (IV) is caused to react with an amide of formula R′R″N—CO—R which is caused to react with a carbonyl group reducing agent to form a compound of formula (II).