Patent ID: 6835718
Filing Date: 2004-12-28
Classification: A61K,B82Y,C08B

Abstract:
A controlled release pharmaceutical micelle composition comprising;a) a biocleavable micelle containing an active agent selected from the group consisting of prodrugs, anticancer drugs, antineoplastic drugs, antifungal drugs, antibacterial drugs, antiviral drugs, cardiac drugs, neurological drugs, alkaloids, antibiotics, bioactive pepticles, steroids, steroid hormones, polypeptide hormones, interferons, interleukins, narcotics, prostaglandins, purines, pyriinidines, anti-protozoan drugs, barbiturates, photosensitizer substances and anti-parasitic drugs, and; b) wherein the micelle contains amphiphilic cyclodextrin molecules selected from the group consisting of alpha-cyclodextrins, beta-cyclodextrmns, gamma-cyclodextrins and their combinations, carboxymethyl cyclodextrins, glucosyl cyclodextrins, maltosyl cyclodextrins, hydroxypropyl cyclodextrins, 2-hydroxypropyl cyclodextrins, 2,3-dihydroxypropyl cyclodextrmns, sulfobutylether cyclodextrins, ethylated cyclodextrins, methylated cyclodextrins, oxidized cydodextrins, sulfonylated cydodextrins, dialdehyde cyclodextrins, amino cyclodextrins, iodinated cyclodextrmns, sulfhydryl cyclodextrins, thiosulfate cyclodextrins, carboxylic acid cyclodextrins, cyclodextrins derivatized through amidation, esterification, acylation, N-alkylation, allylation, ethynylation, oxidation, halogenation, hydrolysis, reactions with anhydrides, hydrazines, other amines, including cyclodextrins derivatized to form acetals, aldehydes, amides, imides, carbonyls, esters, isopropylidenes, nitrenes, osazones, oximes, propargyls, sulfonates, sulfonyls, sulfonamides, nitrates, carbonates, metal salts, hydrazones, glycosones, mercaptals, and combinations of these, cyclodextrin dimers, cyclodextrin trimers, and cyclodextrin polymers, and; c) wherein hydrophilic head groups of said amphiphilic cyclodextrin molecules are covalently cross-linked through a biocleavable linkage selected from the group consisting of a disulfide linkage, a protected disulfide linkage, an ester linkage, an ortho ester linkage, a biocleavable polypeptide, an aromatic azo linkage, an aldehyde bond, a maleimide bond, an NHS bond and a hydrazone linkage, to form a stabilized micelle that has completely entrapped the active agent and wherein the cross-linking provides the function of controlled release.