Patent ID: 7183413
Filing Date: 2007-02-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I): wherein each each of each of R each of R each of R in which A is C 1 –C 12 alkyl optionally containing 1–6 heteroatoms and substituted with sulfonyl, C 1 –C 6 alkylsulfonyl, arylsulfonyl, or heteroarylsulfonyl, C 2 –C 12 alkenyl optionally containing 1–6 heteroatoms, C 2 –C 12 alkynyl optionally containing 1–6 heteroatoms, aryl, heteroaryl, C 1 –C 10 alkylsulfonyl, arylsulfonyl, C 1 –C 10 alkylcarbonyl containing 1–6 heteroatoms, C 2 –C 20 alkylaryl optionally containing 1–6 heteroatoms, C 2 –C 20 arylalkyl optionally containing 1–6 heteroatoms, C 2 –C 20 alkylheteroaryl containing 1–6 heteroatoms, or C 2 –C 20 heteroarylalkyl containing 2–6 heteroatoms; B is H, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, C 3 –C 8 cycloalkyl, C 5 –C 8 cycloalkenyl, C 3 –C 8 heterocycloalkyl, C 5 –C 8 heterocycloalkenyl, aryl, or heteroaryl; or B and A together are heteroaryl; and D is H, aryl, heteroaryl, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, C 3 –C 8 cycloalkyl, C 5 –C 8 cycloalkenyl, C 3 –C 8 heterocycloalkyl, C 5 –C 8 heterocycloalkenyl, —C(O)—R d , —SO 2 —R d , —C(S)—R d , —C(O)—NR d R d ′, —C(O)—OR d , —OC(O)—R d , —C(O)—SR d , or —SC(O)—R d ; or D and A together are heteroaryl; each of R a , R b , R b ′, R c , R c ′, R d , and R d ′, independently, being H, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, C 3 –C 8 cycloalkyl, C 5 –C 8 cycloalkenyl, C 3 –C 8 heterocycloalkyl, C 5 –C 8 heterocycloalkenyl, aryl, or heteroaryl; or R d and R d ′ together being C 5 –C 7 heterocycloalkyl; or a salt thereof.