Patent ID: 6049009
Filing Date: 2000-04-11
Classification: C07B,C07C

Abstract:
A method for producing an optically active trans-vinylsulfide alcohol having the formula (III): ##STR11## wherein R.sup.1 represents an alkyl group or an aryl group, comprising the step of reducing a trans-vinylsulfide ketone having the formula (I): ##STR12## wherein R.sup.1 is the same as defined above with a borane reducing agent in the presence of an optically active oxazaborolidine having the formula (II): ##STR13## wherein R.sup.2 represents a hydrogen atom, an alkyl group, an aryl group or an aralkyl group and R.sup.3 and R.sup.4 are the same or different and represent an alkyl group, an aryl group or an aralkyl group in the presence of at least one sulfide compound selected from the group consisting of dimethylsulfide, methylphenylsulfide, diphenylsulfide, di-n-butylsulfide, di-sec-butylsulfide, di-tert-butylsulfide and dibenzylsulfide as an additive for controlling the reduction of the olefin double bond of the trans-vinylsulfide ketone, wherein said additive prevents coordination of the borane reducing agent to the sulfur atom of the trans-vinylsulfide ketone (I).