Patent ID: 6451809
Filing Date: 2002-09-17
Classification: C07D

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier, adjuvant, or vehicle together with a compound of the formula or a pharmaceutically acceptable non-toxic salt thereof, wherein:R1 and R2 are the same or different and represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, or C3-C7 cycloalkoxy, each of which may be substituted with NR5R6; R5 and R6 are the same or different and represent hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl; or R5 and R6 may be taken together to form a nitrogen containing ring having from 5-7 members; R3 represents hydrogen, C1-C6 alkyl, C1-C6 alkoxy(C1-C6)alkyl, C3-C7 cycloalkyl, or C3-C7 cycloalkoxy(C1-C6)alkyl, where any R3 with the exception of hydrogen may be substituted with NR5R6; and G represents (i) a group of the formula: whereX is C1-C6 alkyleneoxy(C1-C6)alklene, C3-C7 cycloalkylene, or C3-C7cycloalkoxy(C1-C6)alkylene, R7, R7â€², R8â€², and R9 are the same or different and are hydrogen, halogen, hydroxy, C1-C6 alkyl, C1-C6 cyclo(C3-C7)alkyl, â€”OR10, or â€”NR11R12; wherein R10 is alkyl having 1-6 carbon atoms or cycloalkyl having 3-7 carbon atoms; and R11 and R12 are the same or different and represent hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, or R11 and R12 together with the nitrogen to which they are attached form a 3-7 membered ring which is optionally substituted with methyl; (ii) a group of the formula: whereX, R7, R7â€², R8â€², and NR11R12 are as defined above and R8 is defined as R7, R7â€², and R8â€²; (iii) a group of the formula: whereX, R7â€², R8, R8â€², R9, and NR11R12 are as defined above R13 and R14 independently represent hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl, or R13R14 taken together with the carbon atom to which they are attached form a C3-C7 cycloalkyl ring; (iv) a group of the formula: whereX, R7, R7â€², R8â€², R9, R13, R14 and NR11R12 are as defined above; (v) a group of the formula: whereX, R7, R7â€², R8, R8â€², R13, R14 and NR11R12 are as defined above; (vi) a group of the formula: whereR7, R7â€², R8â€², R9, and NR5R6 are as defined above and Z is lower alkyl having 2-6 carbon atoms, or Z may be taken together with R5 or R6 to form a heterocyclic ring; (vii) a group of the formula: whereZ, R7, R7â€², R8, R8â€², and NR5R6 are as defined above; (viii) a group of the formula: whereZ, R7â€², R8, R8â€², R9, R13, R14, and NR5R6 are as defined above; (ix) a group of the formula: whereZ, R7, R7â€², R8â€², R9, R13, R14, and NR5R6 are as defined above; (x) a group of the formula: whereZ, R7, R7â€², R8, R8â€², R13, R14, and NR5R6 are as defined above; (xi) a group of the formula: whereQ represents a heteroaryl group; (xii) a group of the formula: whereR13, R14 and Q are as defined above; (xiii) a group of the formula: whereZ, Q, and N5R6 are as defined above; or (xiv) a group of the formula: whereZ, Q, R13, R14, and NR5R6 are as defined above.