Patent ID: 8337827
Filing Date: 2012-12-25
Classification: A61K,A61P,C12N

Abstract:
1. An isolated cell population comprising: (a) human osteoblasts or osteoblast phenotype cells characterised in that they co-express (1) at least one osteoblast marker selected from alkaline phosphatase (ALP) of the bone-liver-kidney type, procollagen type 1 aminoterminal propeptide (PINP) and bone sialoprotein (BSP) with (2) at least one marker selected from CD63 and CD166, and (b) endothelial cells or progenitors thereof which are CD34 positive and further express at least one, at least two, or all three, of von Willebrand factor (vWF), VEGF and CD133, said isolated cell population comprising at least 80% of human osteoblasts or osteoblast phenotype cells as defined under (a), and wherein the endothelial cells or progenitors thereof as defined under (b) constitute less than 20% of all cells defined under (a) and (b).