Patent ID: 6348478
Filing Date: 2002-02-19
Classification: C07C,C07D

Abstract:
A biphenylamidine compound represented by the formula (1), or a pharmaceutically acceptable salt thereof: (wherein, A represents an amidino group; R1 represents a hydrogen atom, a hydroxyl group, an amino group, a nitro group, a C1-C8 alkyl group, or a C1-C8 alkoxy group; X represents a carboxyl group, an aralkoxycarbonyl group, an aryloxycarbonyl group, a C1-C8 alkoxycarbonyl group, or a hydrogen atom (provided that Y was limited to a case represented by the below-mentioned formula (1-4) when X represents the hydrogen atom); Y represents a group of the following formula (1-1): (wherein, n represents 0 or 1; Z represents Câ€”H or a nitrogen atom; R2 represents a hydrogen atom, an amino group, an amino C1-C4 alkyl group, a C1-C4 alkylamino group or a di-C1-C4 alkylamino group; R3 represents a hydrogen atom, or a C1-C4 alkyl group; R4 represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, a hydroxide group, or a hydroxy C1-C4 alkyl group), or a group of the following formula (1-2): (wherein, k and m each represents an integer of from 0 to 2 (provided that k+m=2); R5 represents a hydrogen atom, an amidino group, or a group of the following formula (1-3): (wherein, R6 represents a C1-C4 alkyl group, an aralkyl group or a phenyl group), or a group of the following formula (1-4): (wherein, the wavy line represents an E isomer, a Z isomer or their mixture on the basis of the double bond in an arbitrary ratio; R7 represents a hydrogen atom or a trifluoroacetyl group).