Patent ID: 9073997
Filing Date: 2015-07-07
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for inhibiting rejection of a vascularized tissue or vascularized organ transplant, or for inhibiting arteriosclerosis in a human allograft transplant recipient, comprising: administering to a human allograft transplant recipient a composition that comprises an endothelial growth factor inhibitor in an amount effective to inhibit rejection, or inhibit arteriosclerosis, wherein the endothelial growth factor inhibitor comprises a compound that inhibits stimulation of human VEGFR-3 by VEGF-C or inhibits stimulation of human VEGFR-3 by VEGF-D, and wherein the compound comprises an antibody that immunoreacts with human VEGFR-3.