Patent ID: 6410561
Filing Date: 2002-06-25
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for treating pain, comprising administering to a host an effective amount of an amide derivative of the formula [1]whereinR1 and R2 are the same or different and each is hydrogen atom, lower alkyl optionally substituted by hydroxy, amino, lower alkylamino or di(lower)alkylamino; R3 and R4 are the same or different and each is hydrogen atom, halogen atom or lower alkyl: ring A is quinolyl; ring B is phenyl, thienyl, furyl, pyrrolyl, pyrrolidinyl, oxazolyl or cyclohexenyl; and X is a group of the formula whereinE is a single bond, carbonyl, sulfinyl, â€”Oâ€”, â€”Sâ€”, â€”NHCOâ€”, â€”CH&boxH;CR6â€” wherein R6 is hydrogen atom or aryl or â€”NR7â€” wherein R7 is hydrogen atom, lower alkyl or lower alkoxycarbonyl; ring G is aryl, a heterocyclic group selected from the group consisting of pyrrolyl, thienyl, furyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, indolyl, benzofuranyl, benzimidazolyl, imidazolidinyl, indolinyl, pyrrolidinyl, carbazolyl and 2,3-dihydrobenzofuranyl, cycloalkyl or condensed aryl; R5 is halogen atom, hydroxy, lower alkyl optionally substituted by any of halogen atom, hydroxy, lower alkanoyloxy and lower alkoxy optionally substituted by lower alkoxy, lower alkoxy optionally substituted by lower alkoxy, amino, lower alkylamino, di(lower)alkylamino, nitro, cyano, lower alkanoyl, lower alkanoyloxy, carboxy, lower alkoxycarbonyl, lower alkylsulfonyl or phenyl; t is 0 or an integer of 1 to 5, which indicates the number of substituents on the ring G, wherein when t is an integer of 2 to 5, each R5 is the same or different; m is 0 or an integer of 1 to 8; and n is 0 or an integer of 1 to 4, or a pharmaceutically acceptable salt thereof.