Patent ID: 6420398
Filing Date: 2002-07-16
Classification: C07D

Abstract:
A compound represented by the following formula [I] or a salt thereof, wherein R1 is hydrogen, lower alkyl, phenyl or a group of the following formula [II]. R2 is hydrogen, lower alkyl, cycloalkyl, phenyl, carboxyl or ester thereof, and can join with sulfur adjacent to A1 to form a nonaromatic heterocycle having sulfur in the ring; R3 and R4, being the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl or phenyl; R5 is hydrogen, lower alkyl, hydroxy or lower alkoxy; R6 is an aromatic heterocycle having nitrogen in the ring; A1 and A2, being the same or different, are lower alkylene; provided that when R6 is imidazolyl or purinyl, at least one of R3 and R4 is not hydrogen; each lower alkyl defined above can be substituted by cycloalkyl, cycloalkenyl, adamantyl, phenyl, halogen, hydroxy, lower alkoxy or an aromatic or nonaromatic heterocycle having nitrogen in the ring; each phenyl defined above can be substituted by lower alkyl, phenyl, hydroxy, lower alkoxy, halogeno-lower alkoxy, halogen, nitro, carboxyl or ester thereof; and the aromatic or nonaromatic heterocycle having nitrogen in the ring defined above can be substituted by lower alkyl, halogeno-lower alkyl, hydroxy-lower alkyl, cycloalkyl, phenyl, halogen, hydroxy or lower alkoxy; and wherein thiol, hydroxy and/or nitrogen of the non-aromatic heterocycle or the aromatic heterocycle are optionally protected with a protecting group, wherein the optional thiol protecting group is an acyl or substituted thiol; the optional hydroxy protecting group acyl, substituted lower alkyl or substituted silyl; and the optional protecting group or the nitrogen of the non-aromatic heterocycle or the aromatic heterocycle is acyl, substituted lower alkyl or substituted sulfonyl.