Patent ID: 6569861
Filing Date: 2003-05-27
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof wherein:Q represents a group of the Formula: â€ƒwherein A is C1-C5 alkylene optionally mono-, di, or trisubstituted with substituents independently chosen from C1-C3 alkyl, C1-C3 alkoxy, halogen, halo(C1-C3)alkyl, halo(C1-C3)alkoxy, hydroxy, amino, and mono- or di(C1-C3)alkylamino; R1, R2, R3, R4, R5, R6, R7, and R8 are the same or different and represent hydrogen, halogen, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di(C1-C6)alkyl amino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, â€”COOH, â€”SO2NH2, mono or dialkylsulfonamido, â€”C(O)NH2, or mono or di(C1-C6)alkylcarboxamido; R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, and R19 independently represent hydrogen or alkyl; W is nitrogen; X represents halogen, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di(C1-C6)alkylamino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, â€”COOH, â€”CONH2, mono- or di(C1-C6)alkylcarboxamido, â€”SO2NH2, mono or di(C1-C6)alkylsulfonamido; or X represents phenyl which may be optionally substituted by up to five substituents, which may be the same or different and are selected from the group consisting of hydrogen, halogen, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di (C1-C6)alkyl amino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, â€”COOH, â€”CONH2, mono- or di-(C1-C6)alkylcarboxamido,â€”SO2NH2, and mono or di(C1-C6)alkylsulfonamido; Y is oxygen, sulfur, â€”S(O)â€”, or â€”SO2â€”; and Z is C1-C6 alkyl or mono, di or trifluoromethyl.