Patent ID: 8034371
Filing Date: 2011-10-11
Classification: A61K,B82Y,Y10S

Abstract:
1. A composition in the form of an aqueous solution for nasal delivery of zolpidem or a pharmaceutically acceptable salt thereof, wherein the composition consists essentially of: (a) 16 to 97 mg/ml of zolpidem (expressed as the free base); (b) 50 to 400 mg/ml of sulfobutylether β-cyclodextrin (SBE-CD); and (c) 1 to 20 mg/ml of chitosan, a salt, or a derivative thereof formed by bonding acyl and/or alkyl groups with the hydroxyl groups, but not the amino groups of chitosan or a salt of the derivative thereof; and wherein the composition has a pH of 3.5 to 5.6 and a viscosity of less than 150 cp.