Patent ID: 8048422
Filing Date: 2011-11-01
Classification: A61K,A61P,C07K

Abstract:
1. A humanized antibody that binds to human TWEAK or an antigen binding fragment thereof comprising: a) heavy chain variable domain complementarity determining regions (CDRs), wherein CDR1 comprises the amino acid sequence set forth in SEQ ID NO:4; CDR2 comprises the amino acid sequence set forth in SEQ ID NO:5; and CDR3 comprises an amino acid sequence set forth in SEQ ID NO:6, or SEQ ID NO:7; and b) light chain variable domain CDRs, wherein CDR1 comprises an amino acid sequence set forth in SEQ ID NO:11; CDR2 comprises an amino acid sequence set forth in SEQ ID NO:13; and CDR3 comprises an amino acid sequence set forth in SEQ ID NO:15.