Patent ID: 9176129
Filing Date: 2015-11-03
Classification: A61P,C07K,C12N,G01N

Abstract:
1. A polypeptide display library comprising a recombinant polypeptide scaffold comprising: (i) seven beta strand domains designated A, B, C, D, E, F, and G, each having at least 95% homology to the amino acids of: (ii) linked to six loop regions such that a loop region connects each beta strand domain, is designated AB, BC, CD, DE, EF, and FG and corresponds to the cognate loop regions of SEQ ID NO:1, the cognate loop regions of SEQ ID NO: 1 consisting of residues: at least one of said loop regions being a non-naturally occurring variant of the cognate loop region in SEQ ID NO: 1; and (iii) a disulfide bond linking the F and G beta strand domains or linking the C and F beta strand domains.