Patent ID: 6677462
Filing Date: 2004-01-13
Classification: A61P,C07C,C07D,C07F

Abstract:
A method of making a compound comprising reacting a compound of formula (II), whereinR1 is independently alkyl, alkenyl, alkynyl, cycloalkyl, arylalkyl, or heteroarylalkyl; R2 is independently alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, each optionally substituted with 1 to 4 independent NR6R6, C(O)NR6R6, OR6, SR6, C(O)OR6, C(O)R6, S(O)nR6, NO2, CN, halo, NR6C(O)R6, or NR6S(O)nR6; Each R6 is independently alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, arylalkyl, or heteroarylalkyl, each optionally substituted with 1-4 independent substituents selected from the group hydroxy, mercapto, amino, alkoxy, carboxylic acid, ester, amido, N-alkyl-substituted amido, halo, nitro, and nitrile; and n is 1 or 2; with a chiral borane reducing agent to give a compound of formula (I): wherein R1 and R2 are as defined above.