Patent ID: 6511977
Filing Date: 2003-01-28
Classification: A61P,C07C,C07D

Abstract:
A compound having the structure or pharmaceutically acceptable salts thereof, prodrug esters thereof, or all stereoisomers thereof, whereinA and B are CH and D is N; X1 is â€ƒwherein the heteroatom is linked to the aromatic ring; (where R3 and R4 are independently H, alkyl, arylalkyl or cycloalkyl, or R3 and R4 can be taken together with the carbon to which they are attached to form a 5 to 8 carbon containing ring); R is H, alkyl, alkenyl, aryl, arylalkyl, heterocycloalkyl, cycloalkyl, or cycloalkylalkyl; R1 is arylalkyl, aryl, alkenyl, heteroaryl, heteroarylalkyl, â€ƒ(where R5a is H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl), or â€ƒ(where R6 and R7 are independently selected from aryl, arylalkyl or cycloalkyl; X2 is a single bond, â€ƒor â€”Oâ€” (where R8 is H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl); R2 is H, alkyl, arylalkyl, â€ƒ(where R10 and R11 are independently selected from H, alkyl, arylalkyl or cycloalkyl, or R10 and R11 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring); and â€ƒ(where R12 is alkyl, arylalkyl, aryl, â€ƒheterocycle, heterocycloalkyl, â€ƒ(where R14 can be any of the R8 groups), alkoxy, CF3, aryloxy, arylalkoxy, cycloalkyl or cycloalkylalkyl, and where R15 and R16 are independently selected from H, alkyl, arylalkyl, aryl, heterocyclo, cycloalkyl, amino, aminoalkyl, or heterocycloalkyl, or R15 and R16 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring which may optionally contain an additional nitrogen atom in the ring and/or an amino group or an aminoalkyl group attached to the ring); and R13 is â€ƒ(wherein this moiety is as defined with respect to R12).