Patent ID: 9056079
Filing Date: 2015-06-16
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of reducing inositol monophosphatase (IMPase) activity in vivo, comprising i) providing a hexapeptide IKEKYP (SEQ ID NO:1) in which up to one amino acid residue is replaced, a functional equivalent of the hexapeptide obtained by alkylation, esterification, or cyclization, or a pharmaceutically acceptable salt thereof; and ii) contacting human IMPase in vivo in the presence of human calbindin D28k with said hexapeptide, thereby reducing the activating effect of said calbindin on said IMPase, wherein said hexapeptide interferes with binding of human calbindin D28k to human IMPase in vitro and reduces the activity of IMPase by at least 50% in vitro.