Patent ID: 7034057
Filing Date: 2006-04-25
Classification: A61P,C07C,C07D,Y02P

Abstract:
1. A method for treating inflammatory disorder associated with TACE (TNF-α) and/or MMP, consisting of Crohn's disease and colitis, osteo and rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, multiple sclerosis, osteoporosis, soriasis and atopidermatitis comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein: M is —(C(R T is selected from the group consisting of R wherein each of the cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl and heteroaryl groups of T is independently unsubstituted or substituted with one to five independently selected R V is selected from the group consisting of alkyl, R wherein each of the cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl and heteroaryl groups of V is independently unsubstituted or substituted with one to three independently selected R W is —(CH X is unsubstituted phenyl; U is —O—(CH n is 0 to 2; n1 is 0 to 2; x is 0 to 2; AA is wherein R 31 and R 32 are the same or different and are each independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, —NR 24 R 25 , —(CH 2 ) 3 NH(C═NH)—NH 2 , —CH 2 C(O)—NH 2 , —CH 2 C(O)OH, —CH 2 SH, —CH 2 S—SCH 2 CH(NH 2 )C(O)OH, —CH 2 CH 2 C(O)OH, —CH 2 CH 2 C(O)NH 2 , —(CH 2 ) 4 NH 2 , —CH 2 CH 2 CH(OH)CH 2 NH 2 , —CH 2 CH(CH 3 ) 2 , —CH(CH 3 )CH 2 (CH 3 ), —CH 2 CH 2 SCH 3 , —CH 2 OH, —CH(OH)(CH 3 ), or R R each R wherein each of the cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl and heteroaryl groups of R each R each of the cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl and heteroaryl groups of R each R each R each R wherein each of the aryl, halo-substituted aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups of R or two R R wherein each of the aryl, halo-substituted aryl, heteroaryl, cycloalkyl, and heterocycloalkyl groups of R or two R each R or two R each R each R each R each R R R R or R with the proviso that at least one of V or T is selected from the group consisting of —C(O)—N(R 3 )(OR 4 ), —C(O)OR 3 and —C(O)NR 24 R 25 .