Patent ID: 6180785
Filing Date: 2001-01-30
Classification: C07D

Abstract:
A process for preparing a 2R-hydroxy-3-[(2-aminophenylthio) ]-3-[(p-alkoxyaryl)] propanoic acid alkyl ester of formula (V) ##STR10##whereinR is an alky, or benzoyl residue,R.sup.1 is hydrogen, an alkyl, alkoxy, aryloxy, phenyl naphthyl, or hydroxy residue, andR.sup.2 and R.sup.3 are independently of each other hydrogen, and alkyl, alkoxy, alkylamino, alkylthio, aryl, or halogen residue;which comprises refluxing 2-aminothiophenol, or 2-aminothionaphthol with a compound of Formula (IV) ##STR11##that is a 5S-(p-alkoxyphenyl)-4R-carboalkoxy-1,3,2-dioxathiolane-2-oxide when X is S, or the corresponding cyclic carbonate, in the presence of an organic solvent and an inert atmosphere, and recovering the resultant compound of Formula (V).