Patent ID: 6203787
Filing Date: 2001-03-20
Classification: A61K,A61P,C12N

Abstract:
A method for preparing a pharmaceutical composition containing alloactivated human donor lymphocytes for treating a tumor in a human patient, comprising the steps of:a) coculturing the following cells ex vivo:lymphocytes from a first human donor allogeneic to the patient, and leukocytes from a second human donor allogeneic to both the first human donor and the patient, so as to alloactivate the lymphocytes; andb) harvesting the cocultured cells and preparing them for human administration at a time after initiation of the coculturing when the harvested cells, upon implantation in the bed of a solid tumor in the patient, are effective in treating the solid tumor or eliciting an anti-tumor immunological response in the patient.