Patent ID: 6670332
Filing Date: 2003-12-30
Classification: A61K,C07C,C07K

Abstract:
A compound of the formula: R1 and R2 are independently H; linear or branched, unsubstituted or substituted C1-23 alkyl, acyl, alkenyl, or heteroalkyl group having from 0 to 6 sites of unsaturation; or a cyclic or aryl group, said heteroalkyl, cyclic, and aryl groups comprising from 0 to 5 heteroatoms wherein said heteroatoms are not the first atoms in said groups, wherein the substituent groups are selected from the group consisting of â€”Oâ€”(CH2)kâ€”CH3, â€”Sâ€”(CH2)kâ€”CH3, and Xâ€”(CH2)kâ€”, wherein X is a halide, and k is 0 to 4; R3 and R4 are independently H; linear or branched, unsubstituted or substituted C1-23 alkyl, acyl, alkenyl, or heteroalkyl group having from 0 to 6 sites of unsaturation; or a cyclic or aryl group, said heteroalkyl, cyclic, and aryl groups comprising from 0 to 5 heteroatoms wherein said heteroatoms are not the first atoms in said groups, wherein the substituent groups are selected from the group consisting of â€”Oâ€”(CH2)kâ€”CH3, â€”Sâ€”(CH2)kâ€”CH3, and Xâ€”(CH2)kâ€”, wherein X is a halide, and k is 0 to 4; R5 has the structure whereinZ is selected from the group consisting of O, S, NR1, NH, Se, and CR7R8; R6 is selected from the group consisting of H, R1, R2, R3, and R4, and, when Z is O, NH, NR1, or S, R6 can further be an amino acid, peptide, polypeptide, protein, mono-, di- or polysaccharide, or other bioactive or pharmaceutical agent, wherein Z is an atom of said amino acid, peptide, polypeptide, protein, mono-, di- or polysaccharide, or other bioactive or pharmaceutical agent; n is 1 to 6; m is 1 to 10; Y is a pharmaceutically acceptable anion; and R7 and R8 independently or in combination are H or alkyl groups as defined for R1 and R2; wherein if Z is O, n is 1, and m is 3, then R6 is selected from the group defined for R3 and R4 and wherein R1 and R2 are not both H.