Patent ID: 8853258
Filing Date: 2014-10-07
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A compound selected from the group consisting of (2R)-4-(4′-cyanobiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(4′-fluorobiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; 4-(2′-fluorobiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; N-hydroxy-4-(4′-methoxybiphenyl-4-yl)-2-methyl-2-(methylsulfonyl)butanamide; N-hydroxy-4-[4-(1H-indol-5-yl)phenyl]-2-methyl-2-(methylsulfonyl)butanamide; 4-[4-(5-cyano-2-thienyl)phenyl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-[4-(1,3-benzodioxol-5-yl)phenyl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)—N-hydroxy-4-[4-(1H-indol-2-yl)phenyl]-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; 4-(2,4′-difluorobiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(4′-glycoloylbiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)—N-hydroxy-4-[4-(6-methoxypyridin-3-yl)phenyl]-2-methyl-2-(methylsulfonyl)butanamide; 4-[4-(3,6-dihydro-2H-thiopyran-4-yl)phenyl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; 4-(4′-cyano-3-fluorobiphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; N-hydroxy-4-[4′-(4-hydroxybutoxy)biphenyl-4-yl]-2-methyl-2-(methylsulfonyl)butanamide; (2R)—N-hydroxy-4-(4′-hydroxybiphenyl-4-yl)-2-methyl-2-(methylsulfonyl)butanamide; 4-[4-(benzyloxy)phenyl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)—N-hydroxy-2-methyl-2-(methylsulfonyl)-4-[4′-(3-morpholin-4-ylpropoxy)biphenyl-4-yl]butanamide; 4-[3-fluoro-4-(6-methoxypyridin-3-yl)phenyl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; 4-(4-cyclohex-1-en-1-ylphenyl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; N-hydroxy-2-methyl-2-(methylsulfonyl)-4-[4-(4-methyl-2-thienyl)phenyl]butanamide; 4-(3-fluoro-4-quinolin-6-ylphenyl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; and 4′-[(3R)-4-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-4-oxobutyl]biphenyl-4-yl dihydrogen phosphate; or a pharmaceutically acceptable salt thereof.