Patent ID: 9150855
Filing Date: 2015-10-06
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method for diagnosing bone disorders in a subject, which method comprises: (a) detecting via a polymerase chain reaction (PCR) method the expression level and/or quantity of miR-31 or of an isoform or variant thereof in a biological sample; and (b) comparing the detected expression level and/or quantity of said miR-31 or of said isoform or variants in said biological sample with a corresponding expression level and/or quantity of said miR-31 in a control sample, and (c) diagnosing osteoporosis or osteopenia in the subject when a higher expression level and/or quantity of miR-31 is detected in the biological sample than in the control sample, wherein a higher expression level and/or quantity of miR-31 detected in the biological sample compared to the control sample is indicative of a risk of developing or having a bone disorder.