Patent ID: 8968741
Filing Date: 2015-03-03
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a B cell proliferative disorder comprising administering to an individual an effective amount of an immunoconjugate comprising an antibody that binds to CD22, comprising: (a) an HVR-L1 of SEQ ID NO: 10; (b) an HVR-L2 of SEQ ID NO: 12; (c) an HVR-L3 of SEQ ID NO: 14; (d) an HVR-H1 of SEQ ID NO: 2; (e) an HVR-H2 of SEQ ID NO: 4; and (f) an HVR-H3 of SEQ ID NO: 6; covalently attached to a cytotoxic agent.