Patent ID: 8987424
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K

Abstract:
1. A cytotoxic conjugate comprising a cell binding agent and a cytotoxic agent, wherein said cell binding agent comprises an antibody or fragment thereof which binds to CA6 glycotope, wherein said antibody or fragment thereof comprises at least one heavy chain variable region and at least one light chain variable region; wherein said heavy chain variable region comprises CDR1, CDR2, and CDR3 regions comprising the amino acid sequences of amino acids 31-35, 50-66, and 99-106 of SEQ ID NO:11, respectively; and wherein said light chain variable region comprises CDR1, CDR2, and CDR3 regions comprising the amino acid sequences of amino acids 24-33, 49-55, and 88-96 of SEQ ID NO:8, respectively.