Patent ID: 6608069
Filing Date: 2003-08-19
Classification: A61P,C07D

Abstract:
A compound of formula (I): whereinZ represents a 5 or 6 membered cycloalkyl, aryl, substituted cycloalkyl, substituted aryl, pyridine, or thiophene; R1 represents hydrogen or methyl; R2 represents hydrogen, C1-12 alkyl, aryl, or aralkyl; k represents 0 or 1; n represents an integer of 5-20; X represents â€”Oâ€”, â€”N(H)â€”, â€”N(C1-6alkyl)-, â€”N(C3-8cycloalkyl)-, â€”N(C1-8alkyl)(C3-8cycloalkyl), â€”N[(CH2CH2O)m(C1-12 alkyl, aryl, or aralkyl)]-, â€”CH2Oâ€”, â€”CH2NHâ€”, â€”CH2N(C1-6alkyl)-, â€”CH2N(C3-8cycloalkyl)-, or â€”C1-12alkylene-; m represents 0-12; Q represents (â€”CH2)p, (â€”CH&boxH;CHâ€”)p, or (â€”Câ‰¡Câ€”)p, where p is an integer of from 0 to 4; y and yâ€² independently represent integers from 0 to 10; R3 represents H, straight or branched C1-12alkyl (optionally substituted by phenyl, â€”COâ€” phenyl, CN, â€”CO(C1-3) alkyl, or â€”CO2(C1-3)alkyl); C2-6 straight or branched alkenyl, C2-6 straight or branched alkynyl or a group â€”C1-3alkylene-NR8R9; wherein R8 and R9 are independently H, C1-3alkyl or together with the N to which they are bonded form a 5 or 6 membered heterocyclic group; R4 and R5 independently represent C1-3 cycloalkyl straight chain or branched C1-6alkyl hydrogen straight chain or branched C2-6alkenyl aryl or substituted aryl; heterocyclic group, substituted heterocyclic group, heteroaryl or substituted heteroaryl group; R6and R7 independently represent O or S; with the proviso that when y and yâ€² both represent 1, k represents 1, R2 represents H or Me, R3 represents H, X represents O or NH, and Z represents phenyl R4 and R5 do not both represent cyclohexyl; or a solvate thereof.