Patent ID: 6472397
Filing Date: 2002-10-29
Classification: C07D

Abstract:
A compound of formula (I): whereinA represents CH2 or CO, B represents a group â€”(CH2)kâ€”, wherein k is an integer of 1-4, or â€”(CH2)mâ€”COâ€”, wherein m is an integer of 0-3, X and Y are different from each other and represent N or CH, W represents a group represented by formula (a): â€ƒwherein R2 and R3 represent independently a hydrogen atom or C1-6 alkyl, R4 represents C1-10 alkyl, C2-10 alkenyl, C2-5 alkynyl, aryl, or C3-8 cycloalkyl, or a group represented by formula (b): â€ƒwherein R5 represents a hydrogen atom, C1-6 alkyl or C6-8 aralkyl, and R6 and R7 independently represent a hydrogen atom or C1-6, alkyl, or a group represented by formula (c): â€ƒwherein R8, R9, R10 and R11 independently represent a hydrogen atom, C1-6 alkyl or C6-8 aralkyl, R12 and R13 independently represent a hydrogen atom or C1-6 alkyl, Z represents a group (II) or (III): â€ƒwherein n is an integer of 1-3, D represents a group â€”Vâ€”(CH2)pâ€”COOR, wherein V represents â€”Oâ€” or a bond, p is an integer of 1-4, R represents a hydrogen atom, C1-8 alkyl which may be substituted by a halogen atom, C5-8 cycloalkyl, benzyl, a five- to eight-membered saturated cycloalkyl group containing an oxygen or sulfur atom, 1,3-bis(C1-6alkoxy)propan-2-yl, 1,3-bis(C1-6alkylthio)propan-2-yl, C1-6alkyl-(OCH2CH2)qâ€” wherein q is an integer of 1-3, C1-6alkyl-(SCH2CH2)râ€” wherein r is an integer of 1-3, Râ€²Râ€³NCOâ€”(CH2)sâ€” wherein s is an integer of 1-3, and Râ€² and Râ€³ independently represent a hydrogen atom or C1-6 alkyl, or an ester moiety which may be removed under physiological conditions, R1 represents a hydrogen atom or C1-6 alkyl which may be substituted by carboxyl, lower alkoxy, carbamoyl, or phenyl, or a pharmaceutically acceptable salt or solvate thereof.