Patent ID: 6759426
Filing Date: 2004-07-06
Classification: A61P,C07D

Abstract:
A compound according to formula (I) wherein:n is 1, 2, 3 or 4; R1 is selected from a. an optionally substituted straight chain or branched chain C1-6 alkyl group, b. an optionally substituted straight chain or branched chain C2-6 alkenyl group, c. an optionally substituted straight chain or branched chain C2-6 alkynyl group, d. Aryl, e. Aromatic heterocycle, f. Heterocycle, and g. hydrogen; where the optional substituents in groups (a), (b) and (c) above are selected from: C3-7 cycloalkyl, Aryl, Aromatic heterocycle, Heterocycle, OR9, NR9R10, S(O)pR9, OC(O)R10, CO2R9, CONR9R10, SO2NR9R10, halo and NHSO2R9, and where p is 0, 1 or 2; R2, R3, R4, R5, R6, R7 and R8 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl optionally substituted by OR9 or halo; R9 and R10 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl; Aryl is a 6-14 membered aromatic monocyclic or fused polycyclic carbocyclic group optionally substituted with one or more groups selected from R11, halo, OR12, NR12R13, NR12CO2R11, CO2R12, NR12SO2R11, CN, haloalkyl, O(haloalkyl), SR12, S(O)R11, SO2R11, OC(O)R12, SO2NR12R13 and C(O)NR12R13, where R11 is straight chain or branched chain C1-6 alkyl and R12 and R13 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl; Aromatic heterocycle is a 5 to 7 membered aromatic ring containing from 1 to 3 heteroatoms, each independently selected from O, S and N, said ring being optionally substituted with one or more groups selected from OR12, NR12R13, CO2R12, NR12CO2R11, R11, halo, CN, haloalkyl, O(haloalkyl), SR12, S(O)R11, SO2R11, OC(O)R12, NR12SO2R11, SO2NR12R13 and C(O)NR12R13; and Heterocycle is a 3 to 8 membered ring containing from 1 to 3 heteroatoms, each independently selected from O, S and N, said ring being saturated or partially saturated, said ring further being optionally substituted with one or more groups selected from OR12, NR12R13, CO2R12, NR12CO2R13, R11, halo, CN, haloalkyl, O(haloalkyl), SR12, S(O)R11, SO2R11, OC(O)R12, NR12SO2R11, SO2NR12R13 and C(O)NR12R13, or a tautomer thereof, or a pharmaceutically acceptable salt or solvate of said or said tautomer.