Patent ID: 6753427
Filing Date: 2004-06-22
Classification: A61P,C07D

Abstract:
A process for producing a pyridopyrimidine of the formula: comprising:(a) contacting a pyrimidine of the formula: with an alkylating agent of the formula Râ€”X1 in the presence of an alkylating base under conditions sufficient to produce an alkylated pyrimidine of the formula: and(b) contacting said alkylated pyrimidine of Formula II-d with an aryl acetate of the formula Ar1â€”CH2â€”CO2R in the presence of a cyclization base under conditions sufficient to produce said pyridopyrimidine of Formula II-e or(a) contacting said pyrimidine of Formula II-c with said aryl acetate of the formula Ar1â€”CH2â€”CO2R in the presence of a cyclization base under conditions sufficient to produce a thiol pyridopyrimidine of the formula: and(b) contacting said thiol pyridopyrimidine of Formula III with said alkylating agent of the formula Râ€”X1 in the presence of an alkylating base under conditions sufficient to produce said pyridopyrimidine of Formula II-e, â€ƒwherein X1 is a leaving group; each R is independently alkyl; Ar1 is aryl.