Patent ID: 8663650
Filing Date: 2014-03-04
Classification: A61K,A61P,C07K

Abstract:
1. An antigenic composition comprising a supramolecular antigenic construct reconstituted in a liposome carrier for increasing antigenicity of the antigenic peptide and yielding conformational sensitive antibodies, wherein the supramolecular antigenic construct comprises an antigenic peptide obtained from beta amyloid protein, wherein the antigenic peptide is modified to have a polyethylene glycol covalently attached at each the N- and the C-terminus, and wherein each polyethylene glycol has a hydrophobic tail covalently attached to each free PEG terminus which is inserted in the hydrophobic lipid bilayer of the liposome carrier, and wherein each polyethylene glycol has a chain length of n=8-5000 which enhances significantly the exposure and accessibility of the peptide sequence and sensitivity of the elicited antibodies towards the respective conformation of the antigenic peptide.