Patent ID: 6218418
Filing Date: 2001-04-17
Classification: A61K,A61P,C07D

Abstract:
A method of treating cell proliferative disorders associated with an altered cell dependent kinase activity, comprising:administering to a mammal in need thereof an effective amount of a compound represented by formula (I): ##STR13##whereinR is a C.sub.3 -C.sub.6 cycloalkyl group optionally substituted with a straight or branched C.sub.1 -C.sub.6 alkyl group; andR.sub.1 is a straight or branched C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.4 alkenyl, cycloalkyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, which is optionally substituted with one or more groups selected from the group consisting of cycloalkyl, hydroxy, alkylthio, alkoxy, amino, alkylamino, dialkylamino, alkoxycarbonylamino, alkoxycarbonylalkylamino, alkylcarbonyl, alkylsulphonyl, alkoxycarbonyl, carboxy, halogen, nitro, aryloxy, arylthio, arylsulphonyl, N-alkyl-piperazinyl, piperidinyl, 4-morpholinyl, arylamino, cyano, alkyl, aryl, oxo, haloaryl, haloarylalkyl, haloaryloxy, haloarylsulphonyl, aminosulphonyl, aminocarbonyl, arylcabonyl, perfluorinated alkyl, and perfluorinated alkoxy groups;or a pharmaceutically acceptable salt thereof.