Patent ID: 8785487
Filing Date: 2014-07-22
Classification: A61P,C07D,C07F

Abstract:
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein: A and B are each independently absent or a monocyclic or polycyclic group independently selected from the group consisting of aryl, heteroaryl, heterocyclic, C L is absent or an aliphatic group; wherein at least one of A, B and L is present; W is G is an optionally substituted 5-membered heteroaryl containing one or more nitrogen atoms, or an optionally substituted 5-membered heteroaryl fused to a mono- or bicyclic ring, wherein the mono- or bicyclic ring is aromatic or non-aromatic, wherein the mono- or bicyclic ring is attached to one of groups A, L and B and wherein the 5-membered heteroaryl contains one or more nitrogen atoms; Q is hydrogen or X X R R Y at each occurence is independently C(O); L 1 -L 2 -L 3 is a linker selected from: wherein R R R Alternatively R U is selected from C(R R R Alternatively two geminal R R Alternatively, CHR R wherein heteroaryl refers to a mono- or polycyclic aromatic radical having one or more ring atom selected from S, O and N; and the remaining ring atoms are carbon, wherein any N or S contained within the ring may be optionally oxidized; “heterocyclic” refers to a non-aromatic ring or a bi- or tri-cyclic group fused system, where (i) each ring system contains at least one heteroatom independently selected from oxygen, sulfur and nitrogen, (ii) each ring system can be saturated or unsaturated (iii) the nitrogen and sulfur heteroatoms may optionally be oxidized, (iv) the nitrogen heteroatom may optionally be quaternized, (v) any of the above rings may be fused to an aromatic ring, and (vi) the remaining ring atoms are carbon atoms which may be optionally oxo-substituted; and “substituted” refers to substitution by independent replacement of one, two, or three or more of the hydrogen atoms with substituents selected from —F, —Cl, —Br, —I, —OH, protected hydroxy, —NO