Patent ID: 6365606
Filing Date: 2002-04-02
Classification: C07D

Abstract:
A compound of Formula I: wherein:rings â€œAâ€  and â€œBâ€ , are unsaturated or partially unsaturated; X1 is selected from CH, or Câ€”Cl; X2 is selected from CR12; X3 is selected from CH; X4 is selected from CH; P1, P2 are both CH; M is N; Q is C1-C3 alkylene or â€”CH&boxH;CHâ€”; R6 is selected from â€”C(R9)3, â€”CH(R9)2, or â€”C3-C8 cycloalkyl; R7 is selected from â€”SH, OH or OCOR9, wherein R9 is defined below; R8 is â€”CH2â€”C4-C6-cycloalkyl; R10 is selected from C1-C3-pyridyl, C3H6OH, â€”Câ‰¡CH, Br, â€”Câ‰¡Câ€”CH2OH, isopropyl, hydrogen, R11 is selected from H, â€”OH, â€”Oâ€”C3-C8-cycloalkyl, â€”SH, â€”Z-pyridyl, â€”Z-thienyl, and â€”Zâ€”CH2OH; R12 is selected from â€”SH, H, halogen or lower alkyl; R9 is lower alkyl; and Z is selected from ethylene, and â€”Câ‰¡Câ€”; and pharmaceutically acceptable salts thereof.