Patent ID: 7060842
Filing Date: 2006-06-13
Classification: C07K,Y02P

Abstract:
1. A process for the industrial synthesis of a compound selected from those of formula (I): wherein R 1 represents hydrogen, linear or branched (C 1 –C 6 )alkyl or benzyl, and R 2 represents a group that protects the amino function, wherein the ester of formula (V): is reacted with the alanine compound of formula (VI): in an organic solvent in the absence of 1-hydroxybenzotriazole or in the presence of an amount of less than 0.6 mol of 1-hydroxybenzotriazole per mol of compound of formula (V) employed, in the presence of an amount of 1 to 1.2 mol of dicyclohexylcarbodiimide per mol of compound of formula (V) employed, and in the presence of an amount of 1 to 1.2 mol of triethylamine per mol of compound of formula (V) employed, at a temperature of 20 to 50° C., to yield, after isolation and then recrystallisation, the compound of formula (VII): which is hydrogenated in the presence of a catalyst under a hydrogen pressure of 1 to 40 bars, at a temperature of 30 to 70° C., to yield the compound of formula (I).