Patent ID: 6100265
Filing Date: 2000-08-08
Classification: C07D

Abstract:
A thiopyran compound or a pharmaceutically acceptable salt thereof represented by the following formula (I) or (I'), ##STR67## wherein, A represents a sulfur atom or the group --CH.dbd.CH--;the dotted line indicates that the bond may be either present or absent;when the dotted line indicates that the bond is present, Z represents the group, ##STR68## and when the dotted line indicates that the bond is absent, Z represents one of the following groups, ##STR69## (wherein R.sub.1 is an alkyl group which may be substituted, an aromatic carbocyclic group which may be substituted, or an aralkyl group which may be substituted, R.sub.2 is a hydrogen atom, an alkyl group which may be substituted, an aromatic carbocyclic group which may be substituted, or an aralkyl group which may be substituted, R.sub.3 is a hydrogen atom, an alkyl group which may be substituted, or an aralkyl group which may be substituted, X.sub.1, X.sub.2 and X.sub.3 individually represent an oxygen atom or a sulfur atom, and G represents an ethylene group, of which one or more hydrogen atoms may be replaced by a halogen atom, alkyl group, aromatic carbocyclic group, aralkyl group, or alkylidene group, or a trimethylene group, of which one or more hydrogen atoms may be replaced by a halogen atom, alkyl group, aromatic carbocyclic group, aralkyl group or alkylidene group);Z' represents the group; ##STR70## (wherein G has the same meaning as defined as above); L is an alkylene group which may be substituted, an alkenylene group which may be substituted, or an alkynylene group which may be substituted;Y represents the group CH, or a nitrogen atom;when Y is the group CH, m is 0 or 1, n is 1 or 2, and B is an oxygen atom, a sulfur atom, a carbonyl group, a sulfinyl group, a sulfonyl group, an alkylene group, an alkenylene group, a hydroxymethylene group which may be substituted, the group --CHR.sub.4 -- (wherein R.sub.4 is an alkyl group which may be substituted, or an aromatic carbocyclic group which may be substituted, or an aralkyl group which may be substituted), or a cyclic or alicyclic acetal group which may be substituted;andwhen Y is a nitrogen atom, m is 0 or 1, n is 2 or 3, and B is a carbonyl group, a sulfonyl group, an alkylene group, an alkenylene group, or a group --CHR.sub.6 --(wherein R.sub.6 is an alkyl group which may be substituted, an aromatic carbocyclic group which may be substituted, or an aralkyl group which may be substituted);E.sub.1 and E.sub.2 individually represent a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; andD represents an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted, wherein when R.sub.1 is a group which is substituted, it is substituted by one or more halogen atoms, alkyl groups, or alkoxy groups; and wherein when R.sub.2 is a group which is substituted, it is substituted by one or more halogen atoms, alkyl groups, or alkoxy groups; and wherein when R.sub.3 is a group which is substituted, it is substituted by one or more halogen atoms, alkyl groups, or alkoxy groups; and wherein when L is a group which is substituted, it is substituted by one or more halogen atoms; and wherein when R.sub.6 is a group which is substituted, it is substituted with at least one halogen atom, alkyl group, or alkoxy group; and wherein when D is substituted, it is substituted by at least one of halogen, an alkyl group, an aromatic carbocyclic group, an aralkyl group, an aralkyloxy group, a cyano group, a nitro group, a carboxyl group, an alkoxycarbonyl group, a lower-alkyl sulfonyl amino group wherein the alkyl portion has 1-4 carbon atoms, a carbamoyl group, or a hydroxyl group, wherein each alkyl group is independently 1-4 carbon atoms, each alkoxy group is independently 1-4 carbon atoms, each aromatic carbocyclic group is independently 6-14 carbon atoms, each aralkyl group is independently 7-22 carbon atoms, each aralkyloxy group is independently 7-22 carbon atoms, each alkylidene is independently 1-4 carbon atoms, each alkylene is independently 2-10 carbon atoms, each alkenylene is independently 4-10 carbon atoms, each alkynylene group is independently 4-10 carbon atoms, and each alkoxycarbonyl group independently has 1-6 carbon atoms in the alcohol portion,and wherein said thiopyran compound or salt thereof excludes said compound and salt wherein, at the same time, Y is nitrogen, n is 2, and D is an aromatic hydrocarbon group which may be substituted.