Patent ID: 7148350
Filing Date: 2006-12-12
Classification: A61K,A61P,C07D

Abstract:
1. A homo or heterodimer prodrug wherein both monomeric units are 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compounds of the formula: wherein R 1 and R 2 are each independently —H, —C 1 –C 6 alkyl, —C 1 –C 6 OH, or —C 1 –C 6 NHR′ wherein R′ is —H, or —C 1 –C 6 alkyl; R 3 is: wherein R 4 is —H, —C 1 –C 6 alkyl, —C 1 –C 6 OH, or —C 1 –C 6 NHR′; R 5 is —H, —OH, —NHR′, —C 1 –C 6 alkyl, —C 1 –C 6 OH, or —C 1 –C 6 NHR′, or R 5 is: wherein R 6 is morpholine, piperidine, hydroxyalkyl piperazine, or aminoalkyl piperazine, wherein alkyl is of C 1 –C 6 ; with the proviso that each monomeric unit has only one functional group alcohol, primary amine or secondary amine through which the monomeric units are coupled to each other via a labile carbonate (—O—COO—), carbamate (—O—CO—N—),urea (—N—CO—N—) or phosphate (—O—POO—O—) moiety.