Patent ID: 6689751
Filing Date: 2004-02-10
Classification: A61K,A61P,C07K,Y10S

Abstract:
A peptide comprising the amino acid sequence of SEQ ID NO: 15 or SEQ ID NO. 83, wherein SEQ ID NO: 15 has a D-alanine substitution at position 2, 3, 4, or 6 or an alpha-aminoisobutyrate substitution at position 7, 8, 9, 11, 12, 13, or 14, or any combination of the above, wherein SEQ ID NO: 83 has a D-alanine substitution at position 2, 3, 4, or 6 or an alpha-aminoisobutyrate substitution at position 7, 8, 9, 11, or 12, or any combination of the above, and wherein the peptide inhibits binding of IGF-I to IGFBP-1.