Patent ID: 6138680
Filing Date: 2000-10-31
Classification: A61K,A61P,B82Y

Abstract:
A method for destroying retinal pigment epithelial cells in a vitreous chamber of a phakic eye following vitrectomy and retina reattachment, said method comprising:providing a solution comprising a heparin binding agent that binds to the basement membrane of said vitreous chamber conjugated to a cytotoxic agent;introducing said solution into said vitreous chamber;maintaining said solution in said vitreous chamber for a predetermined period of time sufficient for said heparin binding agent that binds to the basement membrane of said vitreous chamber to bind to a basement membrane within said vitreous chamber; andremoving said solution from said vitreous chamber; whereby retinal pigment epithelial cells on said basement membrane within said vitreous chamber are exposed to said heparin binding agent that binds to the basement membrane of said vitreous chamber conjugated to a cytotoxic agent such that said retinal pigment epithelial cells are destroyed.