Patent ID: 8124789
Filing Date: 2012-02-28
Classification: A61P,C07K

Abstract:
1. A method for producing N-pyranosyl-tryptophan comprising: a step of allowing a pyranose compound represented by the formula (1): wherein X each independently represent a hydroxyl-protecting group, to react with a 3-pyrazyl-indole compound represented by the formula (2): wherein R 1 , R 2 , and R 3 each independently represent an alkyl group having 1 to 6 carbon atoms, in the presence of a first base to obtain a 1-pyranosyl-3-pyrazyl-indole compound represented by the formula (3): wherein X each independently represent a hydroxyl-protecting group; and R 1 , R 2 , and R 3 each independently represent an alkyl group having 1 to 6 carbon atoms; and a step of treating the 1-pyranosyl-3-pyrazyl-indole compound with an acid, treating the resultant with a hydrogenation catalyst, and further treating the resultant with a second base to obtain N-pyranosyl-tryptophan represented by the formula (4):