Patent ID: 6066668
Filing Date: 2000-05-23
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical formulation comprising a solution or suspension of i) an effective amount of a Platinum analogue; and ii) a compound of the formula: ##STR8## wherein: R.sub.1 is hydrogen, lower alkyl or ##STR9## R.sub.2 and R.sub.4 are each individually SO.sub.3.sup.- M.sup.+, PO.sub.3.sup.2- M.sub.2.sup.2+, or PO.sub.2 S.sup.2- M.sub.2.sup.2+ ;R.sub.3 and R.sub.5 are each individually hydrogen, hydroxy or sulfhydryl;m and n are individually 0, 1, 2, 3 or 4, with the proviso that if m or n is 0, then R.sub.3 is hydrogen; andM is hydrogen or an alkali metal ion; ora pharmaceutically acceptable salt thereof, with the proviso that if the Platinum analogue is cisplatin or carboplatin, then R.sup.1 is not hydrogen and R.sup.2 and R.sup.4 are not the same, and one or more pharmaceutically acceptable carriers, excipients or diluents.