Patent ID: 6548505
Filing Date: 2003-04-15
Classification: A61K,A61P,C07D

Abstract:
A method of protecting biological material from ionizing radiation damage comprising contacting said biological material with an amount effective to protect said material from ionizing radiation damage of a compound of formula (I): whereinX is optionally substituted alkylamino; Y and Z may be the same or different and are selected from N, O, S and C(Râ€²) wherein Râ€² is hydrogen or optionally substituted alkyl; {overscore (---)} is a double bond unless the attached Y or Z group is O or S in which case it is a single bond;  is a single bond unless the attached {overscore (---)} is a single bond in which case  is a double bond and adjacent (H) is absent; and R1 to R11 may be the same or different and are selected from hydrogen, a sterically hindering group and an electron donating group; or any two of R1 to R11, Y, Z, NH and Râ€² may together with the carbon atoms to which they are attached form an optionally substituted ring which may contain heteroatoms provided that at least one of R1 to R11 is an electron donating group and that when X is NCH3, Y and Z are N and R1, R2 and R4 to R11 are hydrogen, then R3 is not OH or OCH2CH3; wherein sterically hindering groups are selected from optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted ring which may contain heteroatoms, NHR, N(R)2 or OR where R is hydrogen or optionally substituted alkyl and wherein electron donating groups are selected from optionally substituted alkyl, optionally substituted alkenyl, NHR, N(R)2 or OR where R is as defined above; and pharmaceutically acceptable salts, hydrates, solvates and/or tautomers thereof.