Patent ID: 8563327
Filing Date: 2013-10-22
Classification: G01N,Y10T

Abstract:
1. A method for diagnosing type 1 diabetes mellitus comprising: obtaining a sample from a subject suspected of having type 1 diabetes mellitus; contacting the sample with two or more purified recombinant proteins selected from the group consisting of alanyl tRNA synthetase, glycyl tRNA synthetase, asparaginyl tRNA synthetase, and tryptophanyl tRNA synthetase, and fragments thereof; detecting the binding of two or more of an anti-alanyl tRNA synthetase antibody, an anti-glycyl tRNA synthetase antibody, an anti-asparaginyl tRNA synthetase antibody, and an anti-tryptophanyl tRNA synthetase antibody in the sample with the two or more purified recombinant proteins, wherein detecting the binding of two or more of the antibodies with the two or more purified recombinant proteins indicates that the subject has type 1 diabetes mellitus.