Patent ID: 8148157
Filing Date: 2012-04-03
Classification: G01N,Y10T

Abstract:
1. A reference, calibrator or control composition comprising PlGF-1 and sFlt-1, where the PlGF-1 comprises alanine in place of: a) proline at position 25 of SEQ ID NO:1, or b) glutamine at position 27 of SEQ ID NO:1, or c) cysteine at position 60 of SEQ ID NO:1, or d) aspartate at position 72 of SEQ ID NO:1 or e) glutamate at position 73 of SEQ ID NO:1, or f) asparagine at position 84 of SEQ ID NO:1, or g) proline at position 98 of SEQ ID NO:1, or h) tyrosine at position 100 of SEQ ID NO:1, or altered PlGF-1 having glycine in place of cysteine at position 70 of SEQ ID NO:1, or any combination of the alanine replacements in a) to h) and the glycine replacement.