Patent ID: 6380224
Filing Date: 2002-04-30
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: in which:R1 is independently selected from the group consisting of hydrogen; hydroxy; halo; C1-8alkyl; substituted C1-8alkyl; C1-8alkoxy; substituted C1-8alkoxy; trifluoroalkyl; C1-8alkylthio; substituted C1-8alkylthio; C3-6cycloalkyl; C3-8cycloalkoxy; nitro; amino; C1-6alkylamino; C1-8dialkylamino; C4-8cycloalkylamino; cyano; carboxy; C1-5alkoxycarbonyl; C1-5alkylcarbonyloxy; formyl; carbamoyl; phenyl; and substituted phenyl; n is 1-2; B1 is hydrogen; B2 is hydrogen; or B1 and B2 are methylene and joined together to form a five or six membered ring; m is 0-3; R2 is pyridyl L is selected from the group consisting of C1-8alkylene; C2-20alkenylene; C2-10alkynylene; C3-7cycloalkylene; C3-7cycloalkylC1-4alkylene; arylC1-4alkylene; &agr;-aminoC4-7alkylene; (N-methylene)pyrrolidin-3-yl; Y is methylene or carbonyl; Z is selected from the group consisting of: aryl; N-sulfonamido; N-(aryl)sulfonamido; arylamido; arylureido; arylacetamido: (aryloxy)carbonylamino; 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; and 1-aryl-2,3-dihydro4-oxo-imidazol-5,5-diyl; R3 is independently selected from the group consisting of C1-6 alkyl; substituted C1-8alkyl; cycloalkyl; substituted cycloalkyl; naphthyl; substituted naphthyl; heteroaryl; and substituted heteroaryl; R4 is independently selected from the group consisting of hydrogen; C1-8alkyl; C1-8alkoxy; substituted C1-8alkoxy; hydroxy; halogen; cyano; nitro; amino; C1-8alkylamino; and C1-8dialkylamino; R5 is independently selected from the group consisting of hydrogen; C1-8alkyl; C1,alkylcarbonyl; aroyl; carbamoyl; amidino; C1-8 alkyl; C1-8alkylaminocarbonyl; (arylamino)carbonyl; and aryl C1-8 alkylcarbonyl; R6 is independently selected from hydrogen and C1-8 alkyl; p is 1-3; q is 1-3; and enantiomers, diastereomers and pharmaceutically acceptable salts thereof;provided that when L is C1-6alkylene; C2-10 alkenylene; C2-10 alkynylene; C3-7cycloalkylene; C3-7cycloalkyl C1-4alkylene; aryl C1-4 alkylene; or âˆ -aminoC4-7alkylene; then Z is phenyl, N-sulfonamido or N-(aryl)sulfonamido; when L is (N-methylene)pyrrolidin-3-yl; then Z is N-sulfonamido; N-(aryl)sulfonamido; 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; benzamido; phenylureido; phenylacetamido or (phenoxy)carbonylamino; and when B1 and B2 are both methylene thus forming a six membered ring and when L is C1-10alkylene; C2-10alkeneylene; C2-10 alkenylene; or arylC1-4alkylene; then Z is other than N-sulfonamido, N-(aryl)sulfonamido or phenyl.