Patent ID: 6096534
Filing Date: 2000-08-01
Classification: A01K,A61K,C07K,C12N

Abstract:
An isolated nucleic acid molecule comprising:a. at least one long terminal repeat (LTR) isolated from an avian sarcoma leukosis virus (ASLV):b. a first nucleic acid sequence selected from a gag region isolated from ASLV:c. a second nucleic acid sequence selected from a pol region isolated from an ASLV: andd. a third nucleic acid sequence selected from a viral envelope region, said third sequence encoding a protein which binds to both avian and mammalian cells whereby a viral particle harboring said nucleic acid molecule can infect both avian and mammalian cells in titers of at least 10.sup.4 /ml, wherein said viral particle is replication competent in avian cells but is replication defective in mammalian cells.