Patent ID: 7517523
Filing Date: 2009-04-14
Classification: A01K,A61K,A61P,C07K,C12N,Y02A

Abstract:
1. An isolated or purified anti-Macrophage Migration Inhibitory Factor (MIF) antibody, wherein the MIF has a molecular weight of approximately 12.5 kDa as determined by SDS PAGE, and wherein the anti-MIF antibody binds to and neutralizes a biological activity of the 12.5 kDa MIF selected from the group consisting of endotoxin lethality, cytokine-mediated toxicity, TNF-α lethality, septic shock, nitric oxide production by a macrophage, an immune response to malaria infection, an inflammatory immune response, induction of parasite killing by macrophages, and delayed type hypersensitivity response.