Patent ID: 6645727
Filing Date: 2003-11-11
Classification: C07K

Abstract:
A negative selection process for enriching and recovering human mesenchymal progenitor cells in a sample containing human mesenchymal progenitor cells wherein said process comprises (1) reacting the sample with an antibody composition containing antibodies capable of binding to the antigens (a) CD2 and/or CD3 and/or CD5 and/or both CD4 and CD8; (b) CD66b and/or CD16 and/or OD11b and/or CD15; and (c) CD19 and/or CD20 and/or CD21 and/or CD22 and/or CD24 and/or Ig, under conditions so that conjugates are formed between the antibodies and cells in the sample containing the antigens (a) CD2 and/or CD3 and/or CD5 and/or both CD4 and CD8; (b) CD66b and/or CD16 and/or OD11b and/or CD15; and (c) CD19 and/or CD20 and/or CD21 and/or CD22 and/or CD24 and/or Ig, on their surfaces; (2) removing the conjugates; and (3) recovering a cell preparation which is enriched in human mesenchymal progenitor cells.