Patent ID: 7432087
Filing Date: 2008-10-07
Classification: A61P,C07C,C07D

Abstract:
1. A method for synthesizing compounds of the following general formula (2S)-1: wherein the group R 1 represents a hydrogen atom, a benzyl, (S)-(+)-p-toluenesulfino, (S)-1-phenylethyl or (S)-1-phenyl-2-hydroxyethyl group or a group of formula —COOR 2 wherein group R 2 represents an aryl group, an aralkyl group or a C 1 -C 6 alkyl group, comprising the steps of: a) diastereo- and enantioselective reduction of the compound of the following formula 2: using the microorganism with an enantiomeric excess of at least about 85% and a diastereomeric excess of at least about 90%; b) protecting the OH group of the alcohol of formula 3 with a group Y; c) reducing the group —COOEt to an alcohol; d) oxidizing the unprotected OH group obtained in c) to obtain the aldehyde of the following general formula II: wherein group Y represents a benzyl, t-butyl or tetrahydropyran group, and wherein said method of synthesis is further comprised of either one of two routes of synthesis identified as method A and method B, wherein method A comprises the steps of: e wherein group Y represents a benzyl, t-butyl or tetrahydropyran group and group R4 represents a C f wherein group Y represents a benzyl, t-butyl or tetrahydropyran group and group R4 represents a C g h e wherein group Y represents a benzyl, t-butyl or tetrahydropyran group and group R f wherein R and wherein group R g