Patent ID: 7815926
Filing Date: 2010-10-19
Classification: A61K,A61L,C12N

Abstract:
1. An implant for articular cartilage repair, comprising a three-dimensional body formed of cancellous bone and having a demineralized section formed by demineralization, the demineralized section containing bone morphogenetic proteins (BMP's) that are released by the demineralization but retained in said body, and a cartilage layer formed on a surface of the demineralized section, said cartilage layer being formed by a method including the steps of: (a) isolating chondrocytes from articular cartilage of a donor; (b) cultivating the isolated chondrocytes in a medium; (c) suspending the cultivated chondrocytes in agarose; (d) adding the cultivated chondrocytes to the demineralized section of said body, whereby the cultivated chondrocytes are stimulated by the BMPs retained in said body; and (e) incubating the cultivated chondrocytes to form a plurality of layers of chondrocytes on the demineralized section, wherein the plurality of layers of chondrocytes forms said cartilage layer.