Patent ID: 9045431
Filing Date: 2015-06-02
Classification: A61K,A61P,C07D

Abstract:
1. A process for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt hemihydrate Form III, comprising slurrying a first mixture comprising: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt Form IV; where said (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt Form IV has an X-ray power diffraction pattern comprising peaks, in terms of 2θ, at about 20.2316°, about 15.340017° and about 17.7719°; and a first solvent; to form said (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt Form III.