Patent ID: 9115362
Filing Date: 2015-08-25
Classification: C12N,C12P,C12Y

Abstract:
1. A mutant microorganism having the ability to produce cadaverine wherein the speE gene encoding putrescine/cadaverine aminopropyl transferase, the speG gene encoding spermidine N-acetyltransferase, the ygjG gene encoding putrescine/cadaverine aminotransferase, the puuP gene encoding putrescine importer, and the puuA gene encoding glutamate-putrescine/glutamate-cadaverine ligase, which are involved in the cadaverine degradation or utilization pathway, are inactivated or deleted, wherein the cadA gene encoding lysine decarboxylase is further amplified or introduced into said mutant microorganism, and wherein the native promoter of at least one gene selected from the group consisting of a dapA gene encoding dihydrodipicolinate synthase, a lysA gene encoding diaminopimelate decarboxylase, and a dapB gene encoding dihydrodipicolinate reductase are replaced with a strong promoter.