Patent ID: 8877156
Filing Date: 2014-11-04
Classification: A61K

Abstract:
1. A multivalent product comprising: a nanoparticle comprising a metal, metal alloy, or metal oxide core; a plurality of ligands bound to the nanoparticle, said ligands selected from the group consisting of cysteine N,N′-tetraacetic acid; diethylenetriaminepentaacetic acid-L-Cys; diethylenetriaminepentaacetic acid lipoic acid; 1,4,7,10-tetracarboxymethyl-1,4,7,10-tetraazacyclododecane-L-Cys; 1,4,7,10-tetracarboxymethyl-1,4,7,10-tetraazacyclododecane-lipoic acid; 2,2′-((2-((1-carboxy-3-mercaptopropyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid; and mixtures thereof; and a plurality of paramagnetic ions coupled to the nanoparticle by the ligands.