Patent ID: 7162372
Filing Date: 2007-01-09
Classification: G16B,Y10S

Abstract:
1. A method of resolving a mixture comprising DNA of more than one individual into genotype profiles for individuals in the mixture comprising: (a) obtaining quantitative allele peak data for alleles present at a first locus in a DNA mixture comprising DNA of more than one individual; (b) solving a best fit mass ratio coefficient vector using data consisting of the quantitative allele peak data obtained in step (a) for possible allele combinations that can be contributed by the individuals of the more than one individual at the first locus; (c) calculating residuals for the possible allele combinations of step (b); (d) selecting an allele combination from the possible allele combinations for the individuals at the first locus having the smallest residual, wherein the smallest residual does not cluster with the second smallest residual, wherein the allele combination selected resolves the DNA in the mixture at the first locus into respective genotype profiles for the individuals; and (e) repeating the steps of obtaining, solving, calculating and selecting for a second locus.