Patent ID: 7074399
Filing Date: 2006-07-11
Classification: A61K

Abstract:
1. A method of treating an inflammation in a lung of a mammal in need thereof, wherein the inflammation involves C/EBPβ-mediated transcription of a gene encoding an inflammatory mediator, comprising administering a therapeutically effective amount of an isolated nucleic acid including a sequence encoding a p20 polypeptide to a cell of the mammal and expressing the p20 polypeptide in the cell, wherein the p20 polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 7, the amino acid sequence set forth in amino acid positions 152 to 296 of SEQ ID NO: 9, or the amino acid sequence set forth in amino acid positions 153 to 297 of SEQ ID NO: 11, thereby treating the inflammation in a lung of the mammal.