Patent ID: 9017960
Filing Date: 2015-04-28
Classification: A61P,C07K,C12N,G16B,G16C

Abstract:
1. A method comprising the steps of: i. obtaining an N-terminal protein crystal of influenza virus subunit PA_N consisting of SEQ ID NO: 7, said crystal is selected from the group consisting of triclinic crystal in space group P1 and cell unit dimensions of a=51.1 Å; b=151.0 Å; c=59.8 Å; α=96.6°; β=96.8°; and γ=109.5°, and a hexagonal crystal in space group P6 ii. determining the three-dimensional structure of the crystal of (i) using an X-ray diffraction method to obtain atomic coordinates of the structure; iii. constructing a three dimensional model; iv. using said three-dimensional model for computationally identifying a compound that binds to a binding site of PA-N of SEQ ID NO: 7, wherein said compound is selected from the group consisting of peptides, proteins, antibodies or immune conjugates; v. synthesizing said compound; and vi. combining said compound with at least a second influenza virus polymerase subunit to determine if said compound modulates the activity of said influenza virus polymerase subunit.