Patent ID: 6180622
Filing Date: 2001-01-30
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a pharmacologically acceptable salt thereof: ##STR16##whereinA represents a bond, --(CH.sub.2)m--, --CHR.sup.8 --, --(CH.sub.2)n--CH.dbd.CH--(CH.sub.2)n'--, --C(.dbd.O)N(--R.sup.9)CH.sub.2 -- wherein R.sup.8 represents hydroxyl, methoxy, halogen, or amino, R.sup.9 represents hydrogen or --(CH.sub.2)pCH.sub.3 wherein p is an integer of 0 to 3, m is an integer of 1 to 3, and n and n' each represent an integer of 0 to 3;R.sup.1 represents hydrogen or lower alkyl;R.sup.2 represents hydrogen, sodium, or potassium; andany one of R.sup.3, R.sup.4, R.sup.5, and R.sup.6 represents a bond and is bonded to A, and the remaining three substituents, which may be the same or different, represent hydrogen, halogen, nitro, cyano, lower alkyl, lower cycloalkyl, lower alkylthio, C.sub.2-4 alkenyl, formyl, lower alkylcarbonyl, arylcarbonyl, or aryl;one or more hydrogen atoms in said lower alkyl, lower cycloalkyl, C.sub.2-4 alkenyl, and aryl groups as a group or a portion of a group, which may be represented by R.sup.3, R.sup.4, R.sup.5, and R.sup.6, may be substituted by a group selected from the group consisting of halogen, nitro, cyano, lower alkylthio, lower alkoxy, hydroxyl, amino, lower cycloalkyl, N-lower alkylamino, formyl, lower alkylcarbonyl, arylcarbonyl, carboxyl, lower alkoxycarbonyl, formylamino, lower alkylcarbonylamino, carbamoyl, (N-lower alkylamino)carbonyl, aminosulfonyl, (N-lower alkylamino)sulfonyl, aminosulfonylamino, (N-lower alkylamino)sulfonylamino, and aryl,or any two of R.sup.3, R.sup.4, R.sup.5, and R.sup.6 may form together a five-membered heterocyclic saturated ring, containing one oxygen atom and one nitrogen atom, in which the ring may be substituted by oxo (.dbd.O), or any two of R.sup.3, R.sup.4, R.sup.5, and R.sup.6 may form together C.sub.3-6 alkylene.