Patent ID: 7439367
Filing Date: 2008-10-21
Classification: A61K,A61P,C07D

Abstract:
1. A process for preparing a sulfinyl compound of formula (I), or a pharmaceutically acceptable salt thereof, which process comprises oxidation of a sulfide compound of formula (II) wherein in both formulae (I) and (II) R characterized in that an oxidizing agent comprising an aqueous alkali or alkali earth metal hypohalite solution, having a concentration in the range of 2 to 5% is added to a suspension or solution of a sulfide compound of formula (II) to form a reaction mixture, wherein a solution of an alkali or alkali earth metal hydroxide is present in the reaction mixture at least during the oxidation step, is added to a suspension or solution of a sulfide compound of formula (II) whereby the pH of the reaction mixture at least during said oxidation step is in the range of from 9 to 12, and optionally reacting a sulfinyl compound of formula (I) to a pharmaceutically acceptable salt thereof.