Patent ID: 7727551
Filing Date: 2010-06-01
Classification: A61K

Abstract:
1. Oral controlled-release pharmaceutical composition, consisting essentially of: a) an active ingredient; b) a macrogolglyceride matrix, optionally in combination with diethylene glycol monoethyl ether or polyethylene glycol hydroxystearate, forming a eutectic mixture melting at 35-37° C., in which matrix the active ingredient is at least partially soluble and/or dispersed and/or embedded or granulated with said macrogolglycerides previously solubilised or suspended in solvent; c) a surface-acting component selected from lecithins, dioctyl sodium sulfosuccinate, sodium lauryl sulfate, sodium sulfosuccinate, and sodium dodecyl sulfate; d) cyclodextrins or a polymer selected from croscarmellose sodium or cross-linked polyvinylpyrrolidone dispersed in or loaded on said surface-activated macrogolglyceride matrix, to obtain a liquid, semisolid or solid form; e) a hydrophilic matrix in the form of a hydrogel consisting of cellulose derivatives, wherein the macrogolglyceride matrix is dispersed within the hydrophilic matrix; and f) optional excipients.