Patent ID: 8993781
Filing Date: 2015-03-31
Classification: C07D,C07F

Abstract:
1. A process for preparing a compound of general formula (I) wherein: —R —R —m is 0 or 1; —R —S —Ar is a C —Z is selected from the group consisting of —OH, —O-succinimide, —O-maleimide, -N-glycine, —N-lysine, —Y-L″-COOH and —Y-L″-SH where Y is N or O; —L and -L″ are each independently selected from the group consisting of a single bond, an optionally branched C —G is selected from the group consisting of succinimidyl ester, sulfa-succinimidyl ester, isothiocyanate, isocyanate, iodoacetamide, maleimide, sulfonyl halides, phosphoramidates, C —L′ is selected from the group consisting of a single bond, a C —A is selected from the group consisting of C said process comprising transforming the synthetic intermediate into a compound of general formula (I) by reacting the intermediate with a carbon source in the presence of a nucleophile selected from the group consisting of water, an alcohol, an amine and a thiol, and of a palladium-containing catalyst; wherein P is a structure identical to the compound of general formula (I) with the exception of the radical R Ar is as defined for the general formula (I), m is 0 or 1, with m being 1 when R