Patent ID: 6686383
Filing Date: 2004-02-03
Classification: A61K,A61P,Y02A

Abstract:
A method for the prophylaxis or treatment of diabetic nephropathy in a mammal comprising the step of administering a pharmaceutically effective amount of a compound or salt thereof represented by formula (I): whereinR1 stands for H or a lower (C1-C4) alkyl; R2 stands for a group represented by the formula â€”COâ€”Dâ€³ where Dâ€³ stands for hydroxy or a lower (C1-C4) alkoxy group, the alkyl moiety of which optionally is substituted with hydroxy, amino, halogen, lower (C2-C6) alkanoyloxy, lower (C4-C7) cycloalkanoyloxy, lower (C1-C6) alkoxycarbonyloxy, lower (C3-C7) cycloalkoxycarbonyloxy or lower (C1-C4) alkoxy; R3 stands for a tetrazolyl, carboxyl group or a group represented by the formula â€ƒwhere i stands for â€”Oâ€” or â€”Sâ€” and j stands for >C&boxH;O, >C&boxH;S or >S(O)m where m is 0, 1 or 2; n stands for 1 or 2; ring A stands for a benzene ring; Y stands for O, N(H) or S, to a mammal in need thereof.