Patent ID: 8354103
Filing Date: 2013-01-15
Classification: A61K,A61P,C07K

Abstract:
1. An isolated human antibody or antigen-binding fragment thereof that specifically binds human angiopoietin-like protein 4 (hANGPTL4), comprising three heavy chain complementarity determining regions, HCDR1, HCDR2 and HCDR3, and three light chain complementarity determining regions, LCDR1, LCDR2 and LCDR3, wherein the amino acid sequences of the HCDR1, HCDR2 and HCDR3 comprise SEQ ID NO:28, 30 and 32, respectively; and the amino acid sequences of the LCDR1, LCDR2 and LCDR3 comprise SEQ ID NO:36, 38 and 40, respectively.