Patent ID: 8119594
Filing Date: 2012-02-21
Classification: C07K

Abstract:
1. A method for inhibiting growth of a cancer cell, the method comprising: providing a linear polypeptide comprising an amino acid sequence, said amino acid sequence being selected from the group consisting of 1) an amino acid sequence defining a binding domain of a β integrin subunit for ERK2 MAP kinase, said binding domain comprising an intervening, centrally located amino acid linker sequence that links opposite terminal end amino acid sequence regions of the binding domain together and is non-essential for binding of the MAP kinase to said binding domain, the amino acid sequence defining the binding domain being selected from the group consisting of RSKAKWQTGTNPLYR (SEQ ID No. 2), RARAKWDTANNPLYK (SEQ ID No. 22) and RSRARYEMASNPLYR (SEQ ID No. 23); and 2) an amino acid sequence defining the binding domain as specified in (1) wherein the linker sequence of the binding domain is deleted such that the opposite terminal end amino acid sequence regions of the binding domain remain and are contiguous with one another in the polypeptide; and treating a cancer cell with an effective amount of said polypeptide to inhibit the growth of the cancer cell.