Patent ID: 9097702
Filing Date: 2015-08-04
Classification: B01J,C40B,G01N

Abstract:
1. A three-dimensional biomimetic tumor system comprising: a first cell of interest; a natural or synthetic hydrogel incorporating the first cell of interest, wherein: the incorporating hydrogel is crosslinked by chemically mediated crosslinking, ionically mediated crosslinking, thermally mediated crosslinking or photocrosslinking, wherein the incorporating hydrogel forms a roughly spherical bead, the value for the elastic modulus of the hydrogel is controlled by the extent of crosslinking of the hydrogel, and the value for the elastic modulus of the hydrogel is in the range of about E=0.5 kPa to E=100 kPa; a second cell of interest of different cell type from the first cell of interest, wherein the second cell of interest is dispersed on, attached to, bound to, disposed or coated on the surface of the hydrogel incorporating the first cell of interest.