Patent ID: 6566390
Filing Date: 2003-05-20
Classification: A61P,C07D

Abstract:
A compound of the formula I in whichX is CH2; Y is CH2; R1, R2, R3 are each independently of one another NH2, COOH; CONH2, CONH(C1-C16)alkyl, CONH(C1-C16)alkenyl, CONH(C1-C6)alkyl-phenyl, where phenyl may be mono- to trisubstituted by O-(C1-C10)alkyl or O-(C1-C10)alkyl-phenyl, CONH(C1-C6)alkyl-benzimidazole, where the benzimidazole ring may be mono- to trisubstituted by S-phenyl, wherein the S-phenyl may be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C10)alkyl, NH2, NH(C1-C6)alkyl, COOH, COO(C1-C6)alkyl, CONH2; (C2-C6)alkynyl, (C1-C6)alkyl-COOH, (C1-C6)alkyl-aryl, where aryl may be phenyl, naphthyl, biphenyl, thienyl or pyridyl and the aryl moiety may in each case be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C10)alkyl, NH2, NH(C1-C6)alkyl, COOH, COO(C1-C6)alkyl, CONH2; biphenyl, 1- or 2-naphthyl, 2-,3- or 4-pyridyl, 2- or 3-furanyl or 2- or 3-thienyl, where the phenyl, biphenyl, naphthyl, pyridyl, furanyl or thienyl rings may in each case be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C10)alkyl, NH2, NH(C1-C6)alkyl, COOH, COO(C1-C6)alkyl, CONH2; (C3-C18)cycloalkyl, where in the alkyl radicals one or more hydrogens may be replaced by fluorine or one hydrogen may be replaced by OH, (C1-C6)alkyl-phenyl or O-(C1-C6)alkyl-phenyl, NCO, NSO3-(C1-C10)alkyl; or in each case two of the radicals R1 and R2 or R2 and R3 or R1 and R3 together form a fused aryl radical, where aryl may be phenyl, naphthyl, biphenyl, thienyl or pyridyl and the aryl moiety may in each case be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C10)alkyl, NH2, NH(C1-C6)alkyl, COOH, COO(C1-C6)alkyl, CONH2; or its physiologically acceptable salts.