Patent ID: 6100054
Filing Date: 2000-08-08
Classification: A61K,C07K,C12N

Abstract:
A recombinant expression vector having a transcription unit comprising the following elements in operable 5'- to 3'-linkage:(1) a promoter permitting the regulation of gene expression in an Aspergillus host cell;(2) a nucleotide sequence permitting translation initiation in an Aspergillus host cell;(3) a lactoferrin-encoding nucleotide sequence selected from the group of sequences encoding a naturally-occurring lactoferrin allelic product, an iron-binding lobe of a native lactoferrin, and an antimicrobial peptide of a native lactoferrin having the amino acid sequence between position 20 and position 71, inclusive, of a naturally-occurring lactoferrin precursor; and,(4) nucleotide sequences permitting translation and transcription termination in an Aspergillus host cell.