Patent ID: 6825198
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A compound of Formula (IA) whereinX and Y are CR and Z is N, or X is N and Y and Z are CR, where R for each occurrence is hydrogen; W is oxy; at least one of R1a, R1b, R1d, and R1e is independently selected from the group consisting of halogen, nitro, amino, cyano, â€”C(O)NH2, and (C1-C4)alkyl, or R1a and R1b taken together form a five- or six-membered, aromatic or partially or fully saturated fused ring, or R1a taken together with R2a or R2b forms a five- or six-membered, fully saturated fused ring; R1c is hydrogen; R2a and R2b are each independently hydrogen, (C1-C4)alkyl, partially or fully saturated (C3-C6)cycloalkyl, or one of which taken together with R1a forms a five- or six-membered, fully saturated fused ring; n is 0, 1, or 2; R3a and R3b are each independently hydrogen, (C1-C4)alkyl, or (C1-C4)alkyl substituted with hydroxy, fluoro, or (C1-C4)alkoxy; R4 is hydrogen, hydroxy, (C1-C4)alkyl, (C1-C4)alkyl substituted with hydroxy or cyano, (C1-C4)alkylcarbonyl, (C1-C4)alkoxy, (C1-C4)alkoxy-carbonyl, or (C3-C4)alkenyl; a nitrogen oxide thereof, a prodrug of said compound or said nitrogen oxide; a pharmaceutically acceptable salt of said compound, said nitrogen oxide, or said prodrug, or a solvate or hydrate of said compound, said nitrogen oxide, said prodrug, or said salt.