Patent ID: 7785626
Filing Date: 2010-08-31
Classification: A61K,A61P

Abstract:
1. A method for treating at least one symptom of gastro-esophageal reflux disease (GERD) in a human suffering from GERD consisting essentially of (i) identifying a proton pump inhibitor (PPI) selected from a group consisting of lansoprazole, omeprazole, pantoprazole, rabeprazole, pariprazole, leminoprazole, and their pharmaceutically acceptable salts, isomers including enantiomers, and pharmaceutically acceptable salts of said isomers, (ii) identifying an H2 receptor antagonist (H2RA) selected from a group consisting of cimetidine, ranitidine, nizatidine and famotidine, and their pharmaceutically acceptable salts, isomers, and pharmaceutically acceptable salts of said isomers, (iii) adopting an oral dose regime consisting essentially of: (iv) orally administering the selected oral dosage forms of the PPI and the H2RA concurrently according to the dose regime to affect a rise in gastric pH to above about 3 within about 2 hours of administration, thereby treating at least one symptom of GERD promptly, optionally with an antacid agent or an alginate, and (v) repeating (iv) if necessary over a prolonged period until 6 hours from the administration of the last dose, wherein the at least one symptom of GERD is selected from a group consisting of heartburn, sour stomach, and upper abdominal pain.