Patent ID: 6924394
Filing Date: 2005-08-02
Classification: C07C

Abstract:
1. A process for preparing 2-(aminomethyl)-1-cyclopentylamine, said process comprising: (i) preparing an activated catalyst by combining a suitable solvent and a catalyst system in a vessel purged with an inert gas, pressurized with hydrogen to about 50-500 psi at a temperature of about 25° C. to about 50° C., wherein said catalyst system comprises either nickel and palladium, wherein said palladium is supported on carbon, or palladium-doped Raney type nickel (ii) contacting said activated catalyst with 1-amino-2-cyano-1-cyclopentene, at least an equimolar portion of anhydrous ammonia, and a solution of an aqueous inorganic base selected from the group consisting of sodium hydroxide, lithium hydroxide and potassium hydroxide; (iii) pressurizing the vessel by raising the temperature of the vessel to a temperature of about 50° C. to about 150° C. and a pressure of hydrogen of about from 500 psi to about 1500 psi and maintaining said temperature and pressure for a time sufficient to obtain crude 2-(aminomethyl)-1-cyclopentylamine; (iv) separating crude 2-(aminomethyl)-1-cyclopentylamine product; and (v) optionally, purifying crude 2-(aminomethyl)-1-cyclopentylamine to obtain purer 2-(aminomethyl)-1-cyclopentylamine.