Patent ID: 7569574
Filing Date: 2009-08-04
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I): wherein R a C a C a C a C a C a C a phenyl-C a phenyl group substituted by the groups R a phenyl-C a phenyl-(CH a phenylcarbonylmethyl group wherein the phenyl moiety is substituted by R a phenyl-(CH a naphthyl-C a naphthyl-(CH a naphthyl-(CH a [1,4]naphthoquinon-2-yl, chromen-4-on-3-yl, 1-oxoindan-2-yl, 1,3-dioxoindan-2-yl or 2,3-dihydro-3-oxo-benzofuran-2-yl group, a heteroaryl-(CH a heteroaryl-(CH a C a C a C an R a phenyl-(CH a naphthyl-(CH a C a C or an amino or arylcarbonylamino group, R a C a C a C a C a C a C a phenyl group which is substituted by R a C a phenyl-C a phenyl-C a heteroaryl group, a phenyl-(CH a phenylcarbonylmethyl group wherein the phenyl moiety is substituted by R a phenyl-(CH a naphthyl-C a naphthyl-(CH a naphthyl-(CH a heteroaryl-(CH a heteroaryl-(CH a C a C a C an R a phenyl-(CH a naphthyl-(CH a C a cyano, carboxy, C an amino, C an amino group substituted by the groups R an amino group substituted by the groups R a C a phenylamino or N-(phenyl)-N—(C a phenyl-C a naphthylamino or N-(naphthyl)-N—(C a naphthyl-C a heteroarylamino or N-(heteroaryl)-N—(C a pyrrolidin-1-yl, piperidin-1-yl, homopiperidin-1-yl, morpholin-4-yl, homomorpholin-4-yl, piperazin-1-yl, 4-(C a C a C a phenyloxy or phenylsulphanyl group wherein the phenyl moiety is substituted in each case by R a phenyl-C a naphthyloxy or a naphthylsulphanyl group wherein the naphthyl moiety is substituted in each case by R a naphthyl-C a heteroaryloxy or heteroarylsulphanyl group or a heteroaryl-C R a C a C a C a C an aryl group or an aryl-C and R a piperidin-1-yl or hexahydroazepin-1-yl group which is substituted in the 3 position or in the 4 position by an amino, C a 3-amino-piperidin-1-yl group wherein the piperidin-1-yl-moiety is additionally substituted by an aminocarbonyl, C a 3-amino-piperidin-1-yl group wherein the piperidin-1-yl moiety is additionally substituted in the 4 position or 5 position by a hydroxy or methoxy group, a 3-amino-piperidin-1-yl group wherein the methylene group is replaced in the 2 position or 6 position by a carbonyl group, a piperidin-1-yl or hexahydroazepin-1-yl- group substituted in the 3 position by an amino, C an azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl or hexahydroazepin-1-yl group which is substituted by an amino-C a piperazin-1-yl or [1,4]diazepan-1-yl group optionally substituted on the carbon skeleton by one or two C a 3-imino-piperazin-1-yl, 3-imino-[1,4]diazepan-1-yl or 5-imino-[1,4]diazepan-1-yl group optionally substituted on the carbon skeleton by one or two C a [1,4]diazepan-1-yl group optionally substituted by one or two C a C a C a C a C a C an N—(C a C an N—(C a C an N—(C a C an N—(C an R R an R an amino group substituted by the group R an amino group substituted by the group R an R a 3-amino-2-oxo-piperidin-5-yl or 3-amino-2-oxo-1-methyl-piperidin-5-yl group, a pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl, hexahydroazepin-3-yl or hexahydroazepin-4-yl group which is substituted in the 1 position by an amino, C or an azetidin-2-yl-C while by the aryl groups mentioned in the definition of the above groups are meant phenyl or naphthyl groups, which may be mono- or disubstituted by R by the heteroaryl groups mentioned in the definitions of the above-mentioned groups are meant a pyrrolyl, furanyl, thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, or a pyrrolyl, furanyl, thienyl or pyridyl group wherein one or two methyne groups are replaced by nitrogen atoms, or an indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group wherein one to three methyne groups are replaced by nitrogen atoms, or a 1,2-dihydro-2-oxo-pyridinyl, 1,4-dihydro-4-oxo-pyridinyl, 2,3-dihydro-3-oxo-pyridazinyl, 1,2,3,6-tetrahydro-3,6-dioxo-pyridazinyl, 1,2-dihydro-2-oxo-pyrimidinyl, 3,4-dihydro-4-oxo-pyrimidinyl, 1,2,3,4-tetrahydro-2,4-dioxo-pyrimidinyl, 1,2-dihydro-2-oxo-pyrazinyl, 1,2,3,4-tetrahydro-2,3-dioxo-pyrazinyl, 2,3-dihydro-2-oxo-indolyl, 2,3-dihydrobenzofuranyl, 2,3-dihydro-2-oxo-1H-benzimidazolyl, 2,3-dihydro-2-oxo-benzoxazolyl, 1,2-dihydro-2-oxo-quinolinyl, 1,4-dihydro-4-oxo-quinolinyl, 1,2-dihydro-1-oxo-isoquinolinyl, 1,4-dihydro-4-oxo-cinnolinyl, 1,2-dihydro-2-oxo-quinazolinyl, 3,4-dihydro-4-oxo-quinazolinyl, 1,2,3,4-tetrahydro-2,4-dioxo-quinazolinyl, 1,2-dihydro-2-oxoquinoxalinyl, 1,2,3,4-tetrahydro-2,3-dioxo-quinoxalinyl, 1,2-dihydro-1-oxo-phthalazinyl, 1,2,3,4-tetrahydro-1,4-dioxo-phthalazinyl, chromanyl, cumarinyl, 2,3-dihydro-benzo[1,4]dioxinyl or 3,4-dihydro-3-oxo-2H-benzo[1,4]oxazinyl group, while the above-mentioned heteroaryl groups may be substituted by R and, unless otherwise stated, the above-mentioned alkyl, alkenyl and alkynyl groups may be straight-chain or branched, as well as the derivatives which are N-oxidised at the cyclic nitrogen atom in the 3 position or 9 position of the hypoxanthine skeleton, as well as the derivatives wherein the 6-oxo group of the hypoxanthine skeleton is replaced by a thioxo group, the tautomers, enantiomers, diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof.