Patent ID: 6620796
Filing Date: 2003-09-16
Classification: B01J,C07H,C40B

Abstract:
A compound of the following Formula I or Iâ€²: whereinL is a phosphorothioate, phosphoramidate, thiophosphoramidate, phosphorthioamidate, or phosphordiamidate, and wherein L is optionally substituted with one or more of the same or different R1 groups; Q is C, O, S or N; R is a (C3-C12) alkyl, a (C3-C12) alkenyl, a (C3-C12) alkynyl, a (C3-C12) aralkyl, a (C3-C12) cycloalkyl, a (C3-C12) cycloalkenyl, a (C3-C12) carbocyclic aryl, or a (C3-C12) heteroaromatic or heteroalicyclic group comprising from 1 to 3 separate or fused ring and 1 to 3 N, O or S atoms, wherein R is not a mononucleotide, a substituted mononucleotide, an oligonucleotide, a substituted oligonucleotide, a polynucleotide, or a substituted polynucleotide; R1, R3, and R4 are each independently selected from a hydrogen or a hydroxyl group or an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted carbocyclic aryl, an optionally substituted mononucleotide, an optionally substituted polynucleotide, or an optionally substituted heteroaromatic or heteroalicyclic group preferably having from 1 to 3 separate or fused ring and 1 to 3 N, O or S atoms; R5 is independently a hydrogen or a hydroxyl group; B is adenine, thymine, cytosine or guanine, wherein the adenine, thymine, cytosine or guanine are optionally substituted with one or more of the same or different alkyl group, carbocyclic aryl group, heteroaromatic or heteroalicyclic group having from 1 to 3 separate or fused ring and 1 to 3 N, O or S atoms, or a heteroaromatic or heteroalicyclic group other than an adenine, thymine, cytosine or guanine; n is an integer from 0 to 4; and enantiomers and pharmaceutically acceptable salts thereof.