Patent ID: 6492126
Filing Date: 2002-12-10
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
A method for identifying a substance that modulates the TGF-&bgr; signaling response comprising:(a) contacting a genetically engineered cell with TGF-&bgr; and a test substance, said cell comprising 1) a reporter gene in operative association with an inducible TGF-&bgr; regulatory element; and 2) a recombinant construct comprising a gene encoding the fchd540 protein; and (b) detecting expression of said gene in operative association with the TGF-&bgr; regulatory element, in which ability of the test substance to modulate the TGF-&bgr; signaling response is indicated by a change in expression of the reporter gene in operative association with the inducible TGF-&bgr; regulatory element as compared to the amount of expression in the absence of the test substance.