Patent ID: 7592322
Filing Date: 2009-09-22
Classification: A61K,A61P,C12N

Abstract:
1. A method of reducing the levels of a viral titer from a Respiratory Syncytial Virus (RSV) and a Parainfluenza Virus (PIV) in a cell of the respiratory tract of a subject comprising the step of co-administering intranasally a first and a second siRNA agent to said subject, wherein said first siRNA agent comprises a sense strand consisting of SEQ ID NO: 4 and an antisense strand consisting of SEQ ID NO:3; and wherein said second siRNA agent comprises a sense strand consisting of 21-23 contiguous nucleotides wherein at least 19 nucleotides are identical to SEQ ID NO: 10, and an antisense strand consisting of 21-23 contiguous nucleotides, wherein at least 19 nucleotides are identical to SEQ ID NO: 9, and wherein 19-21 contiguous nucleotides of said antisense strand of said second siRNA agent are complementary to a target RNA from PIV.