Patent ID: 8222207
Filing Date: 2012-07-17
Classification: A61K,A61P,C07K

Abstract:
1. A method for enhancing the mobilization of hematopoietic stem cells from bone marrow to peripheral blood, comprising: a) administering to a subject in need thereof an effective amount of a TAT-HOXB4H protein having the amino acid sequence of SEQ ID NO:4, wherein the protein increases the absolute number of hematopoietic stem cells in the bone marrow of the subject and is produced by a method comprising: b) allowing the TAT-HOXB4H protein to increase the absolute number of hematopoietic stem cells in the bone marrow of the subject thereby enhancing the mobilization of hematopoietic stem cells to the peripheral blood of the subject, wherein the subject has a solid tumor.