Patent ID: 8202524
Filing Date: 2012-06-19
Classification: A61K,A61P

Abstract:
1. A method for producing polymeric microspheres loaded with drugs, the method comprising the steps of: a) adding a dispersion phase containing a high molecular compound, a drug, and a water-insoluble organic solvent to a dispersion solvent to produce an O/W (oil-in-water) type or O/O (oil-in-oil) type emulsion, or adding a W/O (water-in-oil) type emulsion, which is prepared by emulsifying an aqueous solution, in which a drug is dissolved, in a water-insoluble organic solvent, in which the high molecular compound is dissolved, to the dispersion solvent to produce a W/O/W (water-in-oil-in-water) type emulsion; and b) adding an ammonia solution to the emulsion produced in step a) to convert the water-insoluble organic solvent into water-soluble solvents wherein the addition of ammonia solution results in ammonolysis of water-insoluble organic solvent in the emulsion to convert the water-insoluble organic solvent into water-soluble solvents, and wherein the water-soluble solvents dissolve in aqueous solution to harden a droplet of the emulsion into the polymeric microsphere.