Patent ID: 8420657
Filing Date: 2013-04-16
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: {4-[7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-(4-methyl-piperazin-1-yl)-methanone; {2-Fluoro-4-[2-(4-fluoro-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Fluoro-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone 4-[2-(4-Fluoro-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(2-morpholin-4-yl-ethyl)-benzamide; {2,6-Difluoro-4-[2-(4-isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; 2-{4-[2-(4-Isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-2-methyl-1-morpholin-4-yl-propan-1-one; (1-{4-[2-(4-Isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-cyclopropyl)-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2-Chloro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-cl]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; [7-(3-Fluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-isopropoxy-phenyl)-amine; {2-Fluoro-4-[2-(4-isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2-Chloro-4-[2-(4-isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-phenyl}-morpholin-4-yl-methanone; 2-{4-[2-(4-Isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-1-morpholin-4-yl-ethanone; (4-Isopropoxy-phenyl)-[7-(4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; [7-(3-Chloro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-isopropoxy-phenyl)-amine; (4-Isopropoxy-phenyl)-[7-(3-methyl-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (4-Isopropoxy-phenyl)-{7-[4-(2-morpholin-4-yl-ethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-amine; {4-[2-(3-Chloro-4-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2,6-difluoro-phenyl}-morpholin-4-yl-methanone; (3-Chloro-4-methyl-phenyl)-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (3-Chloro-4-methyl-phenyl)-[7-(4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (4-Fluoro-3-methyl-phenyl)-[7-(4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-isopropoxy-phenyl)-amine; (4-Fluoro-3-methyl-phenyl)-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (3-Chloro-4-methyl-phenyl)-[7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-fluoro-3-methyl-phenyl)-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-methoxymethyl-phenyl)-amine; 1-Morpholin-4-yl-2-[4-(2-p-tolylamino-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-ethanone; 2-{4-[2-(4-Fluoro-3-methoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-1-morpholin-4-yl-ethanone; 1-Morpholin-4-yl-2-[4-(2-phenylamino-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-ethanone; [7-(4-Morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-p-tolyl-amine; (3,4-Diethoxy-phenyl)-[7-(4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; {2-Fluoro-4-[2-(4-fluoro-3-methoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(3,4-Dimethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-fluoro-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-(4-methyl-piperazin-1-yl)-methanone; (3,4-Dimethyl-phenyl)-[7-(4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (3,4-Dimethyl-phenyl)-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; (4-Fluoro-3-methoxy-phenyl)-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; 2-{4-[2-(3,4-Dimethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-1-morpholin-4-yl-ethanone; (3,4-Diethoxy-phenyl)-[7-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; {4-[2-(3,4-Dimethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amine; [7-(3-Chloro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-methoxymethyl-phenyl)-amine; [7-(3-Chloro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(3,4-diethoxy-phenyl)-amine; (4-Isopropoxy-phenyl)-{7-[4-(1-morpholin-4-yl-ethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-amine (racemic); [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amine; (2,6-Difluoro-4-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-phenyl)-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-phenyl-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-pyridin-2-yl-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-pyridin-3-yl-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-pyridin-4-yl-amine; [2,6-Difluoro-4-(2-phenylamino-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(pyridin-2-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(pyridin-4-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(6-methyl-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(5,6-Dimethyl-pyridin-2-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-fluoro-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(4-fluoro-3-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[2-(pyridin-3-ylamino)-pyrrolo [2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[2-(6-methoxy-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[2-(6-isopropoxy-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(6-Isopropoxy-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(3-Fluoro-4-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(6-Methoxy-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(6-Methyl-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Methoxymethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {4-[2-(3-Methoxy-4-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; {2,6-Difluoro-4-[2-(5-methyl-pyridin-3-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; (2,6-Difluoro-4-{2-[3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-phenyl)-morpholin-4-yl-methanone; (4-{2-[6-(cis-3,5-Dimethyl-piperazin-1-yl)-pyridin-3-ylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-2,6-difluoro-phenyl)-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[6-(cis-3,5-dimethyl-piperazin-1-yl)-pyridin-3-yl]-amine; (4-{2-[6-((2R,5S)-2,5-Dimethyl-piperazin-1-yl)-pyridin-3-ylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-2,6-difluoro-phenyl)-morpholin-4-yl-methanone (racemic); [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[6-((2R,5S)-2,5-dimethyl-piperazin-1-yl)-pyridin-3-yl]-amine (racemic); {4-[2-(3,4-Diethoxy-phenylamino)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-2-fluoro-phenyl}-morpholin-4-yl-methanone; {2-Fluoro-4-[2-(4-morpholin-4-ylmethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(3,4-dimethyl-phenyl)-amine; {4-[2-(3,4-Dimethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Chloro-3-methoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-fluoro-phenyl}-morpholin-4-yl-methanone; {4-[2-(4-Fluoro-3-methoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-phenyl}-morpholin-4-yl-methanone; 4-[2-(3,4-Dimethyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-fluoro-N-(2-morpholin-4-yl-ethyl)-benzamide; {2-Fluoro-4-[2-(3-methoxy-4-methyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(3-methoxy-4-methyl-phenyl)-amine; {7-[4-(3,3-Dimethyl-morpholin-4-ylmethyl)-3,5-difluoro-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-(3,4-dimethyl-phenyl)-amine; [2-Fluoro-4-(2-p-tolylamino-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-p-tolyl-amine; (2-Fluoro-4-{2-[4-methyl-3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-phenyl)-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[4-methyl-3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[3-(cis-3,5-dimethyl-piperazin-1-ylmethyl)-4-methyl-phenyl]-amine; {4-[7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-pyridin-2-yl}-(4-methyl-piperazin-1-yl)-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[2-(4-methyl-piperazin-1-ylmethyl)-pyridin-4-yl]-amine; (4-{2-[4-Methyl-3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-phenyl)-morpholin-4-yl-methanone; {5-[7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-2-methyl-phenyl}-(4-methyl-piperazin-1yl)-methanone; {5-[7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-pyridin-2-yl}-(4-methyl-piperazin-1-yl)-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[6-(4-methyl-piperazin-1-ylmethyl)-pyridin-3-yl]-amine; 4-(4-{2-[6-(cis-3,5-Dimethyl-piperazin-1-yl)-5-methyl-pyridin-3-ylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-2,6-difluoro-benzyl)-morpholin-3-one; [5-Chloro-6-(cis-3,5-dimethyl-piperazin-1-yl)-pyridin-3-yl]-[7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; [4-Chloro-3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-[7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[6-(cis-3,5-dimethyl-piperazin-1-yl)-5-methoxy-pyridin-3-yl]-amine; (4-{2-[6-(cis -3,5-Dimethyl-piperazin-1-yl)-pyridin-3-ylamino]-pyrrolo[2,3-d]pyrimidin-7-yl}-2-fluoro-phenyl)-morpholin-4-yl-methanone; [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-[6-(cis-3,5-dimethyl-piperazin-1-yl)-5-methyl-pyridin-3-yl]-amine; and {3-Fluoro-4-[2-(4-isopropoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-morpholin-4-yl-methanone; or a pharmaceutically acceptable salt thereof.