Patent ID: 6372768
Filing Date: 2002-04-16
Classification: A61P,C07D

Abstract:
A method of treating a mammal afflicted with a disease, disorder or condition which is an: acute spinal cord injury; anxiety disorder selected from the group consisting of panic attack, agoraphobia, panic disorder with or without agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder and acute stress disorder; cancer selected from the group consisting of brain, breast, colon, lung, liver, ovarian, prostate, skin and stomach cancers; cancer selected from the group consisting of astrocytomas, carcinomas, glioblastomas, leukemias, lymphomas, melanomas and sarcomas; cognitive disorder selected from the group consisting of amnestic disorders, deliriums, dementias, and cognitive disorders not otherwise specified; emesis; epilepsy; gastrointestinal condition selected from the group consisting of Crohn's disease, inflammatory bowel syndrome and ulcerative colitis; glaucoma; headache disorder selected from the group consisting of migraine, cluster and vascular headaches; Huntington's disease; inflammatory disorder selected from the group consisting of adult respiratory distress syndrome (ARDS), arthritic disorders, asthma, dermatological lesions, gout, inflammatory bowel disease, necrotizing vasculitides, neurogenic inflammation, psoriasis, reperfusion injury, stroke and systemic inflammatory response syndrome; macular degeneration; obesity; neurodegenerative disease selected from the group consisting of Alzheimer's, ALS, multiple sclerosis and Parkinson's; pathological condition selected from the group consisting of cardiomyopathy, diabetic neuropathy and diabetic nephropathy; psychotic condition selected from the group consisting of schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder, shared psychotic disorder, psychotic disorder due to a general medical condition and psychotic disorders not otherwise specified; sleep disorder selected from the group consisting of primary sleep disorders, sleep disorders related to another mental disorder, sleep disorders due to a general medical condition and sleep disorders not otherwise specified; stroke; substance-abuse disorder selected from the group consisting of alcohol-related disorders, amphetamine-related disorders, caffeine-related disorders, cannabis-related disorders, cocaine-related disorders, hallucinogen-related disorders, inhalant-related disorders, nicotine-related disorders, opioid-related disorders, phencyclidine-related disorders, sedative-related disorders, hypnotic-related disorders, anxiolytic-related disorders and polysubstance-related disorders; toxemic condition selected from the group consisting of ARDS, hypovolemic shock, neuron toxicity, septic shock and traumatic shock; or a traumatic condition selected from the group consisting of chest trauma and head trauma, said method comprising the administration to the mammal of a therapeutically effective amount of a compound of the formula I: or pharmaceutically acceptable salts thereof, whereinA and B together form a ring fused to the phenyl ring, said ring being saturated or unsaturated and containing from 5 to 7 ring member atoms, where said ring member atoms may optionally comprise from 1 to 2 heteroatoms selected independently from the group consisting of N, O or S, provided that no two adjacent ring members are heteroatoms; X is oxygen or a single bond; Y is (C1-C6)alkyl; R1 is hydrogen, (C1-C6 alkyl) or a (C1-C6 alkyl) group substituted with â€”NR2R3, wherein R2 and R3 are either selected independently from the group consisting of H, alkyl, aryl, aralkyl or tetrahydronaphthalene, wherein said aryl group or said aryl moiety of said aralkyl group is phenyl or naphthyl, said alkyl group or said alkyl moiety of said aralkyl group contains from one to six carbon atoms and is straight-chained or branched, and said aryl group, said tetrahydronaphthalene or said aryl moiety of said aralkyl group is optionally substituted with from one to three of halogen, nitro, cyano, amino, (C1-C4)alkoxy and (C1-C4)alkylamino moieties, or R2 and R3 form, together with the nitrogen to which they are attached, a heterocyclic ring, or a cyclic or bicyclic ring which is saturated or unsaturated; effective to treat the disease, disorder or condition.