Patent ID: 6806265
Filing Date: 2004-10-19
Classification: A61P,C07D

Abstract:
A compound represented by formula I: whereinR2 is selected from: H, (C1-4)alkyl, halo, haloalkyl, OH, (C1-6)alkoxy, NH(C1-4alkyl) or N(C1-4alkyl)2; R4 is H or Me; R5 is H or Me; R11 is H, (C1-4)alkyl, (C3-4)cycloalkyl and (C1-4)alkyl-(C3-4)cycloalkyl; A is a connecting chain of (C1-3)alkylene; B is O or S; n is 1; wherein Ring C is a 6- or 10-membered aryl said aryl being optionally substituted with from 1 to 4 substituents selected from: halogen and (C1-6)alkyl optionally substituted with OH; E is a single bond connecting group selected from: â€ƒwherein R22 is H or (C1-6)alkyl; â€ƒwherein R23 is H or (C1-6)alkyl; â€ƒwherein R24 is H or (C1-6)alkyl; â€ƒwherein R25 is H or (C1-6)alkyl; â€ƒwherein R26 and R27 is each H or (C1-6)alkyl; â€ƒwherein R28 is H or (C1-6)alkyl; â€ƒwherein R29 is H or (C1-6)alkyl; and andRing D is a 6- or 10-membered aryl or a 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from: O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents selected from: halogen, NH2, NO2, COOH, OH, COO(C1-6) alkyl, (C1-6)alkoxy, (C2-4)alkenyl-COOH, (C3-7)cycloalkyl-COOH and (C1-6)alkyl optionally substituted with COOH or OH; or a salt or a prodrug thereof.