Patent ID: 6706759
Filing Date: 2004-03-16
Classification: A61K

Abstract:
A method of treating cancer in human cells sensitive to a dithiocarbamate thiolate anion of the formula set forth below and for sensitizing tumors to conventional cancer chemotherapy by blocking the P-glycoprotein membrane toxin extrusion pump and for sensitizing AIDS patients to anti-retroviral therapy by blocking the P-glycoprotein membrane toxin extrusion pump comprising administering to a human subject in need thereof a therapeutically effective amount of a dithiocarbamate thiolate anion of the formula: wherein R2 and R3 are the same or different and represent hydrogen, and unsubstituted or substituted alkyl, akenyl, aryl, and alkoxy groups; M is an alkali metal selected from the group consisting of sodium, potassium, calcium, magnesium, barium, and lithium; An is copper; n is the valence of the metal.