Patent ID: 6593342
Filing Date: 2003-07-15
Classification: A61K,A61P,C07D

Abstract:
A method for treating cancer comprising the administration of (a) at least one antitumor agent chosen from cytotoxic agents and (b) an effective amount of a compound of formula (I) or (Ia): in which:X is chosen from &boxH;O, &boxH;S and &boxH;Nâ€”NHâ€”R7, R7 being a phenyl or pyridyl group, R1, R2, R3, and R4 are chosen, independently of each other, from H, OH, a C1-C4 alkyl group, a C1-C4 alkoxy group, a group â€”OCOâ€”R8, R8 being a C1-C4 alkyl group, and a group derived from a saccharide, at least one of the substituents R1, R2, R3, or R4 being other than H, and R2 and R3 together possibly forming a methylenedioxy group, R5 is a phenyl group or a phenyl group substituted 1 to 3 times with groups chosen from H, OH, a C1-C4 alkoxy group, a group â€”OCOR8, a phenyl (C1-C4 alkoxy) group, a group â€”Oâ€”SO2â€”Râ€²8, Râ€²8 being a C1-C4 alkyl group or a CF3 group, and a group derived from a saccharide, R6 is chosen from H, a C1-C4 alkyl group, a group â€”COâ€”R9 and a group â€”Aâ€”R10, R6a is chosen from a group â€”COâ€”R9 and a group â€”Aâ€”R10, R9 being a C1-C4 alkyl group, A being a C1-C4 alkylene group, R10 being chosen from 5- or 6-membered heterocyclic groups containing 1 to 4 hetero atoms chosen from oxygen, sulfur and nitrogen, the CN group, a group â€”COOR11, â€”CONR12R13, a group â€”NR14R15 and a group â€”COR16, R11, R12, R13, R14, R15 and R16 being chosen independently from a hydrogen atom, a C1-C4 alkyl group and a phenyl (C1-C4 alkyl) group, R4 and R6 together also possible forming a â€”COâ€”CH2â€”CH2â€” group.