Patent ID: 7329681
Filing Date: 2008-02-12
Classification: A61K,A61P,C07C,C07D,Y02P

Abstract:
1. A method of treating a disease selected from the group consisting of a transplant rejection selected from kidney, liver, heart, lung, pancreas (islet cells), bone marrow, cornea, small bowel and skin allograft, and heart valve xenograft rejection, an autoimmune disease selected from rheumatoid arthritis, and a viral infection in a mammal selected from hepatitis B infection and hepatitis C infection, comprising the step of administering to said mammal a compound of the formula: wherein: A is (C B is phenyl; and B optionally comprises up to 3 substituents, wherein: the first of said substituents, if present, is selected from R the second of said substituents, if present, is selected from R the third of said substituents, if present, is R D is selected from C(O), C(S), or S(O) wherein: each R wherein n is 0, 1 or 2; and Y is selected from halogen, CN, NO each R the first of said substituents, if present, is selected from R the second of said substituents, if present, is R R the first of said substituents, if present, is selected from R the second of said substituents, if present, is selected from R the third of said substituents, if present, is R each R each R each R R wherein n is 0, 1 or 2; and Z is selected from halogen, CN, NO R wherein any carbon atom in any R