Patent ID: 9198883
Filing Date: 2015-12-01
Classification: A23L,A23V,A61K,A61P

Abstract:
1. A method of administering a composition to a subject comprising: a. administering to the subject at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and b. administering to the subject an anti-diabetic agent comprising a biguanide and/or a thiazolidinedione, wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, isoleucine, valine, and proline; wherein when (a) is leucine, the molar ratio of (a) to (b) is greater than 2; and wherein (a) and (b) are administered sequentially in any order or simultaneously.