Patent ID: 8414899
Filing Date: 2013-04-09
Classification: A61K,Y02A

Abstract:
1. A composition containing an immunogenic conjugate, the conjugate comprising an antigen covalently attached to HSP60-derived peptide sequences selected from the group consisting of: (e) an analog or derivative of p458h (SEQ ID NO: 1) that has at least 70% of the electric and hydrophilicity/hydrophobicity characteristic of human HSP60 from position 458 to position 474, said peptide, analog or derivative being capable of increasing substantially the immunogenicity of the antigen when the conjugate is administered in vivo; wherein the conjugate comprises a weight ratio of HSP60-derived peptide to antigen in excess of 1:1 (w/w); with the proviso that said antigen is other than the capsular polysaccharide (CPS) Vi of