Patent ID: 7141410
Filing Date: 2006-11-28
Classification: C12N,C12P

Abstract:
1. A genetically modified cell from genera Candida, comprising a recombinant expression construct comprising a nucleic acid having a nucleotide sequence encoding a lactate dehydrogenase protein, wherein the nucleic acid encodes a lactate dehydrogenase protein from Bacillus megaterium, Lactobacillus helveticus, or Rhizopus orvzae, and wherein the lactate dehydrogenase protein-encoding nucleic acid is operatively linked to a promoter functional in a yeast cell from a Candida species that is a Candida sonorensis, Candida parapsilosis, Candida naeodendra, Candida methanosorbosa, Candida entomophila, Candida krusei, Candida blankii, or Candida diddensiae cell wherein the cell expresses a metabolic phenotype that is the Crabtree-negative phenotype.