Patent ID: 6197342
Filing Date: 2001-03-06
Classification: A61K,A61L,C03C

Abstract:
A method for impregnating a biologically active, ceramic-glass material with at least one beneficial, physiologically active agent to form a ceramodrug matrix comprising the steps:a) forming one or more drugs into a biodegradable microencapsulated form which degrades in physiological fluids at pH level higher than about 7,b) forming a colloidal suspension of the biologically active, ceramic-glass material by mixing the finely divided biologically active, ceramic-glass material in one or more solvents, optionally void of suspending agent,c) stirring the drug in microencapsulated form prepared in step a with the colloidal suspension prepared in step b to yield a cosuspension of microencapsulated drug and the biologically active, ceramic-glass, andd) removing the solvent in a sequential manner from the suspension formed in step c yielding a ceramodrug matrix impregnated, uniformly or in gradients, with one or more drugs in microencapsulated form.