Patent ID: 6175014
Filing Date: 2001-01-16
Classification: C07D,Y02P

Abstract:
A process for the preparation of a compound of formula (I): ##STR8##wherein Im represents an imidazolyl group of the formula: ##STR9##and R.sup.1 represents a hydrogen atom or a methyl, ethyl, n-propyl or isopropyl group, R.sup.2 and R.sup.3 each represent a hydrogen atom, R.sup.4 represents a methyl group; and n represents 2; or a physiologically acceptable salt or solvate thereof;which comprises reacting a compound of formula (II) ##STR10##or a protected derivative thereof, with a compound of formula (III):HOCH.sub.2 -Im (III)or a salt thereof in the presence of an acid which is a strong mineral acid or a hydrocarbylsulphonic acid at a temperature of from 100 to 200.degree. C. in a high boiling polar solvent, followed where necessary by removal of any protecting groups.