Patent ID: 9115087
Filing Date: 2015-08-25
Classification: A61P,C07C,C07D

Abstract:
1. A method for modulating CXCR2 receptor activity in a subject in need thereof, comprising: administering to the subject an effective amount of at least one compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R R R R R R R R R R X is CR Z is independently selected from OH; a 3 to 10 membered carbocyclic group; a 3 to 10 membered heterocyclic group; benzyl; C where there are two or more Z substitutents, two Z substituents together with the atoms to which they are attached optionally form a 5- to 7-membered carbocyclic or a 4- to 7-membered heterocyclic substituent fused to the ring system; a is 0, 1, 2, 3 or 4, wherein the alkylene group is optionally substituted by OH or NH E is NR each R each R R