Patent ID: 7270960
Filing Date: 2007-09-18
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of screening for the presence of an ovarian carcinoma in a subject comprising: contacting a biological sample from a subject with at least one antibody specific for an HE4a antigen polypeptide, the polypeptide having an amino acid sequence comprising SEQ ID NO: 11, to determine the presence in the biological sample of a molecule naturally occurring in soluble form in the sample and having an antigenic determinant that is reactive with the antibody, under conditions and for a time sufficient to detect binding of the antibody to the antigenic determinant, and therefrom detecting the presence of an ovarian carcinoma, wherein the biological sample is selected from the group consisting of blood, serum, plasma, ascites fluid, and peritoneal fluid.