Patent ID: 8501795
Filing Date: 2013-08-06
Classification: A61P,C07D

Abstract:
1. A compound having the structure I wherein HET-1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms: wherein Y can be N or CH, Z can be N or C, and wherein HET-1 may optionally be substituted with up to three R Q is phenyl, optionally substituted with one, two or three R -L- is a linker selected from —S—CH R with the proviso that the compound is not 1H-Benzimidazole, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(2-pyrazinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; 1H-Benzimidazole, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]thio]-; 1H-Benzimidazole, 1-ethyl-5-(1-piperidinylsulfonyl)-2-[[[3-(2-thienyl)-1H-1,2,4-triazol-5-yl]thio]methyl]-; 1H-Benzimidazole, 6-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(3-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; Imidazo[1,2-a]pyridine, 8-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; Imidazo[1,2-a]pyridine, 6-chloro-2-[[[3-(2-thienyl)-1,2,4-triazol-5-yl]thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(4-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; Imidazo[1,2-a]pyridine, 6-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(2-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; imidazo[1,2-a]pyridine, 6-chloro-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 3H-Imidazo[4,5-b]pyridine, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; or 1H-Benzimidazole, 2-[[[3-(2-furanyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; and pharmaceutically acceptable salts thereof, with the proviso that when the linker (L) is —CH