Patent ID: 6743802
Filing Date: 2004-06-01
Classification: A61K,A61P,C07D

Abstract:
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, whereinR is H, â€”C1-6alkyl or â€”C3-6cycloalkyl; R1 is H, or a â€”C1-6alkyl, â€”C3-6cycloalkyl, â€”C1-6alkoxy, â€”C2-6alkenyl, â€”C3-6alkynyl, â€”C(O)â€”C1-6alkyl, â€”C(O)-aryl, â€”C0-6alkyl)â€”SOnâ€”(C1-6alkyl), â€”C0-6alkyly)â€”SOnâ€”(aryl), phenyl, wherein aryl is selected from phenyl or naphthyl and wherein any of the groups is optionally substituted with 1-3 independent â€”C1-6alkyl, â€”C1-6alkoxy, OH, â€”N(C0-6alkyl)(C0-6alkyl), â€”(C0-6alkyly)â€”SOnâ€”(C1-6alkyl), nitro, CN, &boxH;Nâ€”Oâ€”C1-6alkyl, â€”Oâ€”N&boxH;C1-6alkyl, or halogen substituents; R2 is absent, H, halogen, â€”C1-6alkyl, â€”C3-6cycloalkyl, â€”C1-6alkyl(C3-6cycloalkyl)(C3-6cycloalkyl), â€”C1-6alkoxy, phenyl, nitro, CN, &boxH;Nâ€”Oâ€”C1-6alkyl, â€”Oâ€”N&boxH;C1-6alkyl, â€”N(C0-6alkyl)(C0-6alkyl), â€”NHSOnâ€”(C1-6alkyl), â€”NHC(O)â€”C1-6alkyl, â€”C(O)â€”C1-6alkyl, â€”C(O)â€”Oâ€”C1-6alkyl, â€”C1-6alkyl(&boxH;Nâ€”OH), â€”C(N&boxH;NOH)C1-6alkyl, â€”C0-6alkyl(oxy)C1-6alkyl-phenyl, â€”SOnNH(C0-6alkyl), or â€”(C0-6alkyl)â€”SOnâ€”(C1-6alkyl), wherein the phenyl, is optionally substituted with halogen, â€”C1-6alkyl, â€”C1-6alkoxy, hydroxy, â€”N(C0-6alkyl)(C0-6alkyl), or â€”C(O)â€”Oâ€”C1-6alkyl, and any alkyl is optionally substituted with 1-6 independent halogen or â€”OH substituents; n is 0, 1, or 2; R3 is absent, H, OH, â€”N(C0-6alkyl)(C0-6alkyl), halogen or C1-6alkyl, wherein any alkyl is optionally substituted with 1-6 independent halogen, OH, or â€”N(C0-6alkyl)(C0-6alkyl) substituents; R4, R5, R6, and R7 each independently is H, halogen, â€”C1-6alkyl, â€”C1-6alkoxy, â€”SOnâ€”(C1-6alkyl), nitro, CN, or â€”N(C0-6alkyl)(C0-6alkyl), and any alkyl is optionally substituted with 1-6 independent halogen or â€”OH substituents; and R8 is pyridyl or pyridonyl, or pyridyl N-oxide.