Patent ID: 7407772
Filing Date: 2008-08-05
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method for appropriately selecting a statin and a non-statin drug for co-administration to a patient in need of such co-administered drug treatment to avoid or minimize an increase in the plasma levels of the open-acid form of the statin, wherein the open-acid form of the statin is susceptible to human metabolic glucuronidation to form an acyl glucuronide conjugate by a human uridine 5′-diphosphate-glucuronosyltransferase (UGT) isozyme, comprising: (a) testing the statin in a human UGT-specific glucuronidation assay to identify which one or more UGT isozymes are responsible for glucuronidation of the open-acid form of the statin to form an acyl glucuronide conjugate, and (b) selecting the non-statin as appropriate for co-administration with the statin if: