Patent ID: 6737421
Filing Date: 2004-05-18
Classification: A61P,C07D

Abstract:
A compound of the formula I or II in whichA is a saturated or monounsaturated carbocyclic system which has 3 to 8 carbon atoms and may additionally have a fused-on benzene ring, it being possible for the rings also to be substituted by one or two different or identical radical R3 and also the radical R4, and R1 is hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6-alkyl, OH, nitro, CF3, CN, NR11R12, NHâ€”COâ€”R13 or Oâ€”C1-C4-alkyl where R11 and R12 are, independently of one another, hydrogen or C1-C4-alkyl, and R13 is hydrogen, C1-C4-alkyl-phenyl or phenyl, and R2 is hydrogen or branched and unbranched C1-C6-alkyl, and R3 is C1-C6-alkyl, OH, Oâ€”C1-C4-alkyl, Oâ€”C1-C4-alkyl-phenyl, NR11R12, phenyl, C1-C4-alkyl-phenyl, CF3, COOH, COOC1-C4-alkyl, CONHâ€”C1-C4-alkyl or CONH2, it being possible for the phenyl rings also to be substituted by a maximum of two identical or different radicals R31, and R31 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro or NR11R12, and R4 is â€”(O)pâ€”(CH2)qâ€”B, where B is NR41R42, p can be 0 or 1, and q can be 0, 1, 2 or 3, where if q is O p is also O, and R41 is hydrogen, C1-C6-alkyl or (CH2)râ€”E and R42 is hydrogen, C1-C6-alkyl, â€”COâ€”R8, SO2â€”R8, â€”(C&boxH;NH)â€”R8 or â€”(C&boxH;CH)â€”NHR8 and r is 0,1,2,3 or 4 and E is phenyl which may also carry a maximum of two radicals R72, and, if r?0 or 1, E is NR11R12, NHâ€”C1-C4-alkyl-phenyl, pyrrolidine, piperidine, dihydropiperidine, morpholine, homopiperidine or piperazine, which may also be substituted by C1-C6-alkyl or C1-C4-alkyl-phenyl, and homopiperazine, which may also be substituted by C1-C6-alkyl and C1-C4-alkyl-phenyl, and homopiperazine, which may also be substituted by C-1-C6-alkyl or C1-C4-alkyl-phenyl and R7 is hydrogen, C1-C6-alkyl or phenyl, it being possible for the ring also to be substituted by up to two identical or different radicals R71, and R71 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro NR11R12 or NHOC1-C4-alkyl and R72 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NR11R12 or NHOC1-C4-alkyl and R8 is C1-C6-alkyl, phenyl, C1-C4-alkyl-phenyl or Oâ€”C1-C4-alkyl-phenyl, it being possible for the rings also to be substituted by up to two identical or different radicals, and R81 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3 nitro r NR11R12, and R9 is hydrogen, C1-C6-alkyl, C1-C4-alkyl-phenyl or phenyl, it being possible for the rings also to be substituted by up to two radicals R91, and R91 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro or NR11R12, or their tautomeric forms, possible enantiomeric or diastereomeric forms, and possible cistrans isomers on the rings in A.