Patent ID: 6339066
Filing Date: 2002-01-15
Classification: A61K,C07H,C07J,C12N,C12P,C12Q,C12Y

Abstract:
An antisense oligonucleotide having up to 50 nucleoside units which specifically binds mRNA encoding an isoform of human Protein Kinase C, wherein said isoform of human Protein Kinase C is selected from the group consisting of PKC-&bgr;I, PKC-&bgr;II, PKC-&ggr;, PKC-&dgr;, PKC-&egr;, PKC-&zgr; and PKC-&eegr;, and said antisense oligonucleotide inhibits the expression of said isoform of human Protein Kinase C, at least about 75% of the nucleoside units of said antisense oligonucleotide being joined together by Sp phosphorothioate 3â€² to 5â€² linkages.