Patent ID: 8242149
Filing Date: 2012-08-14
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar wherein each occurrence of WR m is 0-5; each of R X is a bond or is an optionally substituted C R R R R R′ is independently selected from hydrogen or an optionally substituted group selected from a C provided that the following compounds of 4) 1H-Indole-3-acetamide, α-oxo-N-4-pyridinyl- 5) 1H-Indole-3-acetamide, α-oxo-N-3-pyridinyl- 6) 1H-Indole-3-acetamide, N-(4-nitrophenyl)-α-oxo- 7) 1H-Indole-3-acetamide, N-(4-fluorophenyl)-α-oxo- 8) 1H-Indole-3-acetamide, 6-nitro-α-oxo-N-4-pyridinyl- 9) 1H-Indole-3-acetamide, 5-nitro-α-oxo-N-4-pyridinyl- 10) 1H-Indole-3-acetamide, α-oxo-N-3-pyridinyl- 11) 1H-Indole-3-acetamide, α-oxo-N-4-pyridinyl- 13) 1H-Indole-3-acetamide, N-(4-fluorophenyl)-α-oxo- 22) Benzoic acid, 3-[(1H-indol-3-yloxoacetyl)amino]-, methyl ester 23) 1H-Indole-3-acetamide, α-oxo-N-4-pyridinyl- 26) 1H-Indole-3-acetamide, 5-hydroxy-α-oxo-N-4-pyridinyl- 27) 1H-Indole-3-acetamide, N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-α-oxo- 29) 1H-Indole-3-acetamide, α-oxo-N-phenyl- 30) 1H-Indole-3-acetamide, 5-chloro-α-oxo-N-phenyl- 31) 1H-Indole-3-acetamide, 5-nitro-α-oxo-N-phenyl- 32) 1H-Indole-3-acetamide, N-(4-methoxyphenyl)-α-oxo- 33) 1H-Indole-3-acetamide, 5-chloro-N-(4-methoxyphenyl)-α-oxo- 34) 1H-Indole-3-acetamide, N-(4-methoxyphenyl)-5-nitro-α-oxo- 35) 1H-Indole-3-acetamide, N-(4-hydroxyphenyl)-α-oxo-(9CI) 36) 1H-Indole-3-acetamide, 5-chloro-N-(4-hydroxyphenyl)-α-oxo- 37) 1H-Indole-3-acetamide, N-(4-hydroxyphenyl)-5-nitro-α-oxo- 38) 1H-Indole-3-acetamide, α-oxo-N-3-pyridinyl- 39) 1H-Indole-3-acetamide, N-1H-imidazol-2-yl-α-oxo- 40) 1H-Indole-3-acetamide, N-1H-imidazol-2-yl-α-oxo-, monohydrochloride 41) 1H-Indole-3-acetamide, N-(2,6-dichlorophenyl)-α-oxo- 42) 1H-Indole-3-acetamide, 5-chloro-N-(2,6-dichlorophenyl)-α-oxo- 43) 1H-Indole-3-acetamide, N-(2,6-dichlorophenyl)-5-methoxy-α-oxo- 44) 1H-Indole-3-acetamide, 5-bromo-N-(2,6-dichlorophenyl)-α-oxo- 45) 1H-Indole-3-acetamide, N-(2,6-dichlorophenyl)-5-nitro-α-oxo- 46) 1H-Indole-3-acetamide, α-oxo-N-(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)- 47) 1H-Indole-3-acetamide, 5-bromo-α-oxo-N-(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)- 48) 1H-Indole-3-acetamide, 5-nitro-α-oxo-N-(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)- 50) 1H-Indole-3-acetamide, 5-acetyl-α-oxo-N-phenyl- 51) Indole-3-glyoxylanilide, 5-methoxy- 52) Indole-3-glyoxylamide, 5-(benzyloxy)-N-(4-methyl-2-pyridyl)- 53) Indole-3-glyoxylamide, 5-(benzyloxy)-N-2-pyridyl- 54) Anthranilic acid, N-(indol-3-ylglyoxyloyl)- 55) Benzoic acid, p-(2-indol-3-ylglyoxylamido)- 56) Indole-3-glyoxylanilide, 4′-acetyl- 57) Benzoic acid, m-(2-indol-3-ylglyoxylamido)- 58) 1H-Indole-3-acetamide, α-oxo-N-phenyl- 59) 1H-Indole-3-acetamide, α-oxo-N-phenyl- 60) Indole-3-glyoxylamide, 5-(benzyloxy)-N-2-pyridyl- 61) Indole-3-glyoxylamide, 5-(benzyloxy)-N-3-pyridyl- 62) Indole-3-glyoxylamide, 5-(benzyloxy)-N-4-pyridyl- 63) Indole-3-glyoxylanilide, 5-(benzyloxy)- 65) 1H-Indole-3-acetamide, α-oxo-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-(9CI) (CA INDEX NAME) 67) 1H-Indole-3-acetamide, α-oxo-N-4H-1,2,4-triazol-4-yl- 69) 1H-Indole-3-acetamide, α-oxo-N-(4,5,6,7-tetrahydro-2-benzothiazolyl)- 71) 1H-Indole-3-acetamide, N-(1-cyclohexyl-1H-benzimidazol-5-yl)-α-oxo- 72) 1H-Indole-3-acetamide, N-(4-bromo-2,6-dimethylphenyl)-α-oxo- 74) 1H-Indole-3-acetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-α-oxo- 75) 1H-Indole-3-acetamide, N-(3-cyanobenzo[b]thien-2-yl)-α-oxo- 76) Benzo[b]thiophene-3-carboxylic acid, 2-[(1H-indol-3-yloxoacetyl)amino]-, ethyl ester 77) 1H-Indole-3-acetamide, α-oxo-N-[3-(trifluoromethyl)phenyl)- 78) 1H-Indole-3-acetamide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-α-oxo- 79) Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[(1H-indol-3-yloxoacetyl)amino]-, ethyl ester 80) 1H-Indole-3-acetamide, N-(2-methoxyphenyl)-α-oxo- 81) 1H-Indole-3-acetamide, N-1-naphthalenyl-α-oxo- 82) Benzoic acid, 4-[(1H-indol-3-yloxoacetyl)amino]-, methyl ester 83) 1H-Indole-3-acetamide, N-(4-methylphenyl)-α-oxo- 84) 1H-Indole-3-acetamide, N-(3,4-dimethylphenyl)-α-oxo- 85) 1H-Indole-3-acetamide, α-oxo-N-2-thiazolyl- 87) 1H-Indole-3-acetamide, N-(4-iodophenyl)-α-oxo- 88) 1H-Indole-3-acetamide, N-(3-methylphenyl)-α-oxo- 89) 1H-Indole-3-acetamide, N-(2-methylphenyl)-α-oxo- 90) 1H-Indole-3-acetamide, N-(4-bromophenyl)-α-oxo- 91) 1H-Indole-3-acetamide, N-(3-chlorophenyl)-α-oxo- 92) 1H-Indole-3-acetamide, N-(4-ethoxyphenyl)-α-oxo- 93) 1H-Indole-3-acetamide, N-(2-ethylphenyl)-α-oxo- 94) 1H-Indole-3-acetamide, 5-bromo-N-(4-fluorophenyl)-α-oxo- 96) 2-(5-bromo-1H-indol-3-yl)-N-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-oxo-acetamide 97) N-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide