Patent ID: 9095430
Filing Date: 2015-08-04
Classification: A61F,A61K,A61L,Y10S

Abstract:
1. A method to process calf pericardium tissue for human implantation comprising: excising a portion of calf pericardium tissue from an animal less than 12 months old, sizing the tissue to be fashioned into a construct for implantation in a human patient, testing the tissue to measure an elastin content of greater than 326 micrograms per milligram dry weight, testing the tissue to measure a ratio of hydroxyproline to proline greater than 1.0, selecting tissue portions having the elastin content greater than 326 micrograms per milligram dry weight and the ratio of hydroxyproline to proline greater than 1.0 for use in human implantation as a dural patch or component of a prosthetic heart valve, and wherein the selected tissue portions are chemically treated to synthetically cross-link amino acid residues in the tissue portions to reduce immunogenicity.