Patent ID: 7321042
Filing Date: 2008-01-22
Classification: A61P,C07D

Abstract:
1. A process for preparing N-substituted 3β-aminonortropanes of formula I or an acid addition salt thereof, wherein R wherein either (a) a corresponding 3-oxonortropane of formula IIA  is reacted with an arylmethylamine of formula IIIA  wherein  Ar denotes an optionally substituted phenyl group or an optionally substituted 5- or 6-membered heteroaromatic group with at least one heteroatom selected from the group N, O and S; or (b) a corresponding 3α-aminonortropane of formula IIB  is reacted with an arylaldehyde of formula IIIB converting the resulting imine of formulae IVA prepared in option (a) or IVB prepared in option (b) to the thermodynamically stable compound of formula V in the presence of a base which is then hydrolysed in the presence of an acid to obtain the compound of formula I, which may be optionally converted into an acid addition salt.