Patent ID: 6638912
Filing Date: 2003-10-28
Classification: A61K,A61L,C07K

Abstract:
A pharmaceutical composition, comprising:at least two components, one component being a TGF-&bgr; mimic having cellular proliferation inhibition activity, and being a six or seven amino acid peptide, having the sequence AAi-AAi+1-AAi+2 as an initial sequence defining the N-terminus of said peptide or having the sequence Ala-AAi-AAi+1-AAi+2, said peptide further having an AAi+n adjacent or proximal to said sequence in the C-terminus direction, wherein n is 3, 4, or 5 such that said peptide contains nâˆ’3 additional amino acid residues in between AAi+2 and AAi+n, and wherein AAi is alanine, asparagine, or leucine, AAi+1 is valine, isoleucine, &agr;-amino isobutyric acid, or &agr;-amino butyric acid, AAi+2 is alanine or N-methyl alanine, and AAi+n is glutamic acid, aspartic acid, glutamine, or asparagine, or other amino acid possessing a side-chain with a hydrogen bond acceptor, the other component being a collagen receptor ligand, said collagen receptor ligand having a domain including at least -Ile-Ala- folded in a &bgr;-bend at physiologic conditions; and a physiologically acceptable carrier.