Patent ID: 6165787
Filing Date: 2000-12-26
Classification: A01K,A61K,C07D,C07F,C07H,C07K,C12N,C12P

Abstract:
A eukaryotic cell comprising at least one genetic construct encoding a chimeric protein, which chimeric protein comprises:(a) at least one ligand-binding domain which binds to a selected ligand to form a ligand cross-linked protein complex including the chimeric protein, the ligand having one or more of the following characteristics;(i) the ligand is not a protein,(ii) the ligand has a molecular weight less than 5 kD, and(iii) the ligand is membrane permeable; and(b) an action domain, which is heterologous with respect to at least one of the ligand-binding domains, and which induces a biological process in the cell as a result of formation of the ligand cross-linked protein complex.