Patent ID: 6624306
Filing Date: 2003-09-23
Classification: C07D,C08F

Abstract:
A compound of formula Ia or IIa whereinY is selected from the group consisting of R1 is hydrogen, â€”COOH, â€”COO(C1-C4alkyl), â€”COO-phenyl, â€”COObenzyl, C1-C8alkoxy, C1-C18alkyl, C2-C4alkenyl, C1-C18alkyl or C2-C4alkenyl substituted by OH, â€”COOH, â€”COO(C1-C4)alkyl, C2-C18alkyl which may be interrupted by one or more oxygen atom, unsubstituted cyclopentyl, cyclohexyl, cyclohexenyl, phenyl or naphthyl; or cyclopentyl, cylohexenyl, phenyl or naphthyl which are substituted by C1-C4alkyl, â€”COOH or â€”COOâ€”(C1-C4alkyl); R2 is hydrogen, C1-C18alkyl or R1 and R2 together with the nitrogen atom form a 5-membered ring which may have an unsaturated bond or be fused to a benzene ring; R3 is hydrogen or C1-C18alky; and X is selected from the group consisting of â€”(C5-C12)-3-cycloalkenyl, â€”CH2-phenyl, CH3CH-phenyl, (CH3)2C-phenyl, (C5-C6cycloalkyl)2CCN, (CH3)2CCN, â€”CH2CH&boxH;CH2, CH3CHâ€”CH&boxH;CH2 (C1-C4alkyl)CR20â€”C(O)-phenyl, (C1-C4alkyl-CR20â€”C(O)â€”(C1-C4alkoxy, (C1-C4alkyl-CR20â€”C(O)â€”(C1-C4alkyl, (C1-C4alkyl-CR20â€”C(O)â€”N-di(C1-C4alkyl, (C1-C4)alkyl-CR20â€”C(O)â€”NH(C1-C4alkyl, (C1-C4alkyl-CR20â€”C(O)â€”NH2, wherein R20 is hydrogen or (C1-C4)alkyl; with the proviso that benzoic acid 2,6-diethyl-2,3,6-trimethyl-1-(1-phenyl-ethoxy)-piperidin-4-yl ester and 1-(1-phenylethoxy)-2,2-dimethyl-6,6-diethyl-4-benzoyloxypiperidine are excluded.