Patent ID: 6369072
Filing Date: 2002-04-09
Classification: A61K,C07D

Abstract:
A compound of the formula: D is oxygen, sulfur, or nitrogen; E is carbon or nitrogen; Y is a bond, methylene, C(O), or CH(OH); R1 is alkyl containing 1 to 12 carbons, aryl of 6-12 carbon atoms, arylalkyl of 7-15 carbon atoms, halogen, carboxaldehyde, trifluoromethyl, alkoxy of 1-6 carbon atoms, 2,2-dimethyl-1,3-benzodioxole, Het-alkyl wherein the alkyl moiety contains 1-6 carbon atoms, or aryl of 6-10 carbon atoms which is mono-, di-, or tri-substituted with halogen, trifluormethyl, or alkoxy of 1-6 carbon atoms; G is oxygen, sulfur or nitrogen; R2 and R2a are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, trifluoromethyl; R3 and R4 are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, trifluoromethyl, alkoxy of 1-6 carbon atoms, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfoamide, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, â€”NR7(CH2)mCO2H, pyrrolidinone, a heterocycic ring containing 5 to ring 7 atom rings having 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur, or aryl of 6-10 carbon atoms mono-, di-, or tri-substituted with trifluoromethyl, alkyl of 1-6 carbon atoms or, alkoxy of 1-6 carbon atoms; R5 is hydrogen, alkyl of 1-6 carbon atoms, â€”CH(R8)R9, â€”C(CH2)nCO2R10, â€”C(CH3)2CO2R10, â€”CH(R8)(CH2)nCO2R10, â€”CH(R8)C6H4CO2R10 R6 is alkylene of 1 to 3 carbon atoms R7 is hydrogen or alkyl of 1 to 6 carbon atoms, R8 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, phthalic acid, or Q-alkyl wherein the alkyl moiety contains 1-6 carbon atoms; W is oxygen, sulfur, or nitrogen; R9 is â€”CO2R12, â€”CONHR12, tetrazole, â€”PO3R12; R10 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 7-15 carbon atoms, or aralkyl of 7-15 carbon atoms; R12 is hydrogen, alkyl, aryl of 6-12 carbon atoms, aralkyl of 7-15 carbon atoms; m=1-3; n=1-6; with the proviso that when R1 is halogen, Y is a bond; or a pharmaceutically acceptable salt thereof.