Patent ID: 6175021
Filing Date: 2001-01-16
Classification: A61P,C07D

Abstract:
A 1H-indole-3-glyoxylamide of the invention represented by the formula (I), or a pharmaceutically acceptable salt thereof; ##STR48##wherein;each X is independently oxygen or sulfur;R.sub.1 is selected from groups (a), (b) and (c) where;(a) is C.sub.7 -C.sub.20 alkyl, C.sub.7 -C.sub.20 alkenyl, C.sub.7 -C.sub.20 alkynyl, carbocyclic radicals, or heterocyclic radicals, or(b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or(c) is the group --(L)--R.sub.80 ; where, --(L)-- is a divalent linking group of 1 to 12 atoms selected from carbon, hydrogen, oxygen, nitrogen, and sulfur; wherein the combination of atoms in --(L)-- are selected from the group consisting of (i) carbon and hydrogen only, (ii) sulfur only, (iii) oxygen only, (iv) nitrogen and hydrogen only, (v) carbon, hydrogen, and sulfur only, and (vi) and carbon, hydrogen, and oxygen only; and where R.sub.80 is a group selected from (a) or (b);R.sub.2 is hydrogen, halo, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.4 cycloalkyl, C.sub.3 -C.sub.4 cycloalkenyl, --O--(C.sub.1 -C.sub.2 alkyl), --S--(C.sub.1 -C.sub.2 alkyl), or a non-interfering substituent having a total of 1 to 3 atoms other than hydrogen;R.sub.4 and R.sub.5 are independently selected from hydrogen, a non-interfering substituent, or the group, --(L.sub.a)--(acidic group); wherein --(L.sub.a)-- is an acid linker having an acid linker length of 1 to 4; provided, that at least one of R.sub.4 and R.sub.5 must be the group, --(L.sub.a)--(acidic group);R.sub.6, and R.sub.7 are each independently selected form hydrogen, non-interfering substituents, carbocyclic radicals, carbocyclic radicals substituted with non-interfering substituents, heterocyclic radicals, and heterocyclic radicals substituted with non-interfering substituents.