Patent ID: 8742076
Filing Date: 2014-06-03
Classification: A61K,A61P,C07D

Abstract:
1. An antibody-drug conjugate compound selected from the structures: wherein p is 1, 2, 3, 4, 5, 6, 7, or 8; and Ab is an antibody which binds to one or more tumor-associated antigens or cell-surface receptors selected from (1)-(36): (1) BMPR1B (bone morphogenetic protein receptor-type IB), (2) E16 (LAT1, SLC7A5), (3) STEAP1 (six transmembrane epithelial antigen of prostate), (4) 0772P (CA125, MUC16), (5) MPF (MPF, MSLN, SMR, megakaryocyte potentiating factor, mesothelin), (6) Napi3b (NAPI-3B, NPTIIb, SLC34A2, solute carrier family 34 (sodium phosphate), member 2, type II sodium-dependent phosphate transporter 3b), (7) Sema 5b (FLJ10372, KIAA1445, Mm.42015, SEMA5B, SEMAG, Semaphorin 5b Hlog, sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B), (8) PSCA hlg (2700050C12Rik, C530008O16Rik, RIKEN cDNA 2700050C12, RIKEN cDNA 2700050C12 gene), (9) ETBR (Endothelin type B receptor), (10) MSG783 (RNF124, hypothetical protein FLJ20315), (11) STEAP2 (HGNC (12) TrpM4 (BR22450, FLJ20041, TRPM4, TRPM4B, transient receptor potential cation channel, subfamily M, member 4), (13) CRIPTO (CR, CR1, CRGF, CRIPTO, TDGF1, teratocarcinoma-derived growth factor), (14) CD21 (CR2 (Complement receptor 2) or C3DR (C3d/Epstein Barr virus receptor) or Hs 73792), (15) CD79b (CD79B, CD79β, IGb (immunoglobulin-associated beta), B29), (16) FcRH2 (IFGP4, IRTA4, SPAP1A (SH2 domain containing phosphatase anchor protein 1a), SPAP1B, SPAP1C), (17) HER2, (18) NCA, (19) MDP, (20) IL20Rα, (21) Brevican, (22) EphB2R, (23) ASLG659, (24) PSCA, (25) GEDA, (26) BAFF-R (B cell-activating factor receptor, BLyS receptor 3, BR3), (27) CD22 (B-cell receptor CD22-B isoform), (28) CD79a (CD79A, CD79α, immunoglobulin-associated alpha), (29) CXCR5 (Burkitt's lymphoma receptor 1), (30) HLA-DOB (Beta subunit of MHC class II molecule (Ia antigen)), (31) P2X5 (Purinergic receptor P2X ligand-gated ion channel 5), (32) CD72 (B-cell differentiation antigen CD72, Lyb-2), (33) LY64 (Lymphocyte antigen 64 (RP105), type I membrane protein of the leucine rich repeat (LRR) family), (34) FcRH1 (Fc receptor-like protein 1), (35) IRTA2 (Immunoglobulin superfamily receptor translocation associated 2), and (36) TENB2 (putative transmembrane proteoglycan).