Patent ID: 7553970
Filing Date: 2009-06-30
Classification: C07D,C12P

Abstract:
1. A process for preparing enantiomer-enriched compounds of the formula (VI), in which heteroaryl is a monocyclic aromatic radical having a total of 6 ring atoms, where one or two ring atoms, selected from the group oxygen, sulphur and nitrogen, is present and where the monocyclic aromatic radical is optionally substituted, once, twice or three times, by radicals which are selected, in each case independently of each other, from the group hydroxyl, C R comprising: a) reducing compounds of the formula (I) in which heteroaryl is defined as in formula (IV), and W is C(O)YR W is CN,and R by contacting said compounds of the formula (I) with microorganisms selected from the group consisting of in the presence of water having a pH range of from 3 to 11, based on 25° C.; to yield enantiomer-enriched compound of formula (II), where, in each case, heteroaryl and W have the meanings mentioned under formula (I), and b) performing one of the following manipulations, i)when W is CON(R when W is CN, aminolyizing/hydrolyzing the compounds of the formula (II) directly to yield compounds of the formula (IV), or initially hydrolyzing, partially hydrolyzing or both alcoholyzing/hydrolyzing the compounds of formula (II) to yield compounds of the formula (V) in which heteroaryl has the meaning given under formula (I) and R c) reducing the enantiomer-enriched compounds of the formula (IV) to yield enantiomer-enriched compounds of the formula (VI) having the abovementioned meaning.