Patent ID: 8309597
Filing Date: 2012-11-13
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula (I) wherein R denotes hydrogen, halogen, C  wherein in each above-mentioned alkyl, cycloalkyl, cycloheteroalkyl, alkenyl, and alkynyl group optionally one to three CH R  wherein each alkyl, cycloalkyl, alkenyl, and alkynyl group is optionally mono- or polysubstituted with fluorine and optionally monosubstituted with hydroxy, C (het)aryl is selected from the group consisting of phenyl, naphthyl, pyrrolyl, furanyl, thienyl, tetrazolyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl, and isoquinolinyl, or  selected from the group consisting of pyrrolyl, furanyl, thienyl, and pyridyl in all of which 1 or 2 CH-groups are replaced by N, or  selected from the group consisting of indolyl, benzofuranyl, benzothiophenyl, quinolinyl, and isoquinolinyl, in all of which 1 to 3 CH-groups are replaced by  N, or  selected from the group consisting of 1,2-dihydro-2-oxo-pyridinyl, 1,4-dihydro-4-oxo-pyridinyl, 2,3-dihydro-3-oxo-pyridazinyl, 1,2,3,6-tetrahydro-3,6-dioxo-pyridazinyl, 1,2-dihydro-2-oxo-pyrimidinyl, 3,4-dihydro-4-oxo-pyrimidinyl, 1,2,3,4-tetrahydro-2,4-dioxo-pyrimidinyl, 1,2-dihydro-2-oxo-pyrazinyl, 1,2,3,4-tetrahydro-2,3-dioxo-pyrazinyl, 2,3-dihydro-2-oxo-indolyl, 2,3-dihydrobenzo-furanyl, 2,3-dihydro-2-oxo-1H-benzimidazolyl, 2,3-dihydro-2-oxo-benzoxazolyl, 1,2-di-hydro-2-oxo-quinolinyl, 1,4-dihydro-4-oxo-quino-linyl, 1,2-dihydro-1-oxo-isoquinolinyl, 1,4-dihydro-4-oxo-cinnolinyl, 1,2-dihydro-2-oxo-quinazolinyl, 1,4-dihydro-4-oxo-quina-zolinyl, 1,2,3,4-tetrahydro-2,4-dioxo-quinazolinyl, 1,2-dihydro-2-oxoquinoxalinyl, 1,2,3,4-tetrahydro-3-oxo-quinoxalinyl, 1,2,3,4-tetrahydro-2,3-dioxo-quinoxalinyl, 1,2-dihydro-1-oxo-phthalazinyl, 1,2,3,4-tetrahydro-1,4-dioxo-phthalazinyl, chromanyl, coumarinyl, 2,3-dihydro-benzo[1,4]dioxinyl, and 3,4-dihydro-3-oxo-2H-benzo[1,4]oxazinyl, dihydroquinazolinyl, 3,4-dihydro-1H-isoquinolin-2-yl-carbonyl, 1,3-dihydro-isoindol-2-yl-carbonyl, 2,3-dihydro-indol-1-yl-carbonyl, and 1,2,4,5-tetrahydro-benzo[d]azepin-3-yl-carbonyl,  wherein the above-mentioned (het)aryl rings are optionally mono- or polyfluorinated and are optionally substituted with 1, 2, 3, or 4 substituents selected independently of each other from L L whilst each of the above-mentioned alkyl or alkylene moieties may be branched or unbranched, a tautomer, a stereoisomer thereof, a mixture thereof, or a salt thereof, with the proviso (P1) that the compounds of the general formula (I) wherein R is hydroxycarbonyl, (2-methyl-1-oxo-2-propenyl-1-yl)oxy-, bromo, 4-hydroxyphenyl, 4-hydroxy-3-nitrophenyl, 3-amino-4-hydroxyphenyl, 4-(3-benzyloxy-4-nitro-phenoxy)-phenyl, or 4-(4-amino-3-hydroxy-phenoxy)-phenyl are excluded, and with the proviso (P2) that the compounds of the general formula (X) wherein W is methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, n-butyloxycarbonyl, i-butyloxycarbonyl, (1-methyl-propyl-1-oxy)-carbonyl, t-butyloxycarbonyl, n-pentaloxycarbonyl, (3-methyl-butyl-1-oxy)-carbonyl, n-hexyloxycarbonyl, n-heptyloxycarbonyl, or n-octyloxycarbonyl, are excluded.