Patent ID: 7393654
Filing Date: 2008-07-01
Classification: A01K,A61K,C07H,C07K,G01N

Abstract:
1. A method for identifying a compound that putatively modulates or elicits bitter taste in a human subject comprising: (A) screening one or more compounds in an assay that screens for compounds that activate or modulate the activity of a T2R polypeptide that has a sequence that is at least 95% identical to the human T2R polypeptide of SEQ ID NO:4; and which T2R polypeptide specifically binds to at least one bitter ligand that binds to the human T2R polypeptide of SEQ ID NO:4; and (B) identifying at least one compound that results in the activation of said T2R polypeptide or which modulates the activity of said T2R polypeptide and wherein said T2R polypeptide used in said screening method specifically binds to ligands that specifically bind to the human T2R polypeptide in SEQ ID NO:4.