Patent ID: 6037365
Filing Date: 2000-03-14
Classification: C07D

Abstract:
A compound having the formula: ##STR23## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen, halogen, alkoxy, alkyl hydroxy;W is selected from the group consisting of hydrogen, alkyl, alkenyl, aryl or alkoxycarbonyl any of which may be substituted by alkyl, aryl or substituted aryl wherein each aryl substituent is selected from halo, alkoxy and alkyl;A is selected from the group consisting of alkyl radicals, alkenyl radicals, alkynyl radicals, and alicyclic radicals, wherein each of said radicals may be optionally substituted with hydroxyl, alkoxy, alkyl, halo, aryl or substituted aryl, wherein the aryl substituent is selected from the group consisting of halo, nitro, alkoxy and alkyl;Z is a lactone structure which is represented by the formula: ##STR24## wherein R.sup.3 and R.sup.4 are independently selected from the group consisting of hydrogen, halo, alkoxy, alkyl and hydroxy;R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of hydrogen, alkoxy, alkyl, alkenyl, alkyl sulfonyl, aryl sulfonyl; phosphate, phosphinate, phosphonate, each of which is attached through phosphorus and may be substituted on one or more of its oxygen atoms by alkyl, aryl, alkenyl or hydrogen; heterocyclic, phenyl, and substituted phenyl wherein each phenyl substituent is selected from halo, alkoxy, and alkyl;u is an integer form 1 to 2;p is an integer form 0 to 2; orZ is a lactone which is fused to a benzene ring and represented by the formula ##STR25## wherein Q is one or more substituents of the benzene ring which may be in any positions and are selected from the group consisting of hydrogen, halo, hydroxy, alkyl and alkoxy, and R.sup.9 is selected from the group consisting of hydrogen, halo, carboxyl, alkoxycarbonyl, alkyl or alkoxy.