Patent ID: 7015307
Filing Date: 2006-03-21
Classification: A61P,C07K

Abstract:
1. A method of purifying a compound of formula I: wherein: R R R R each R each R each R each R R each R R each Y is independently selected from the group consisting of oxygen, sulfur, —S—S—, —NR each Z is independently selected from hydrogen, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; and x is 1 or 2; or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof; provided at least one of R (a) contacting a first acidified aqueous solution comprising a compound of formula I with a polystyrene divinyl benzene resin; (b) eluting the contacted resin with a second acidified aqueous solution comprising a polar organic solvent to form an eluate; and (c) isolating the compound of formula I from the eluate.