Patent ID: 8592379
Filing Date: 2013-11-26
Classification: A61K,A61P,C07K

Abstract:
1. A metastin derivative (I) represented by the formula (I) wherein Z 1 , Z 3 and Z 5 are the same or different and each is a hydrogen atom or C 1-3 alkyl, are the same or different and each is —CH 2 —, —CO— or —CS—, R (1) an optionally substituted C (2) an optionally substituted 5- to 14-membered aromatic heterocyclic group consisting of 1 to 7 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (3) an optionally substituted C (4) an optionally substituted 5- to 14-membered aromatic fused heterocyclic group consisting of 3 to 11 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (5) an optionally substituted nonaromatic cyclic hydrocarbon group having a carbon number of not more than 7, and (6) an optionally substituted nonaromatic heterocyclic group having a carbon number of not more than 7, R (2) aralkyl having an optionally substituted basic group, and optionally further having other substituent(s), (3) C (4) C R (1) an optionally substituted C (2) an optionally substituted 5- to 14-membered aromatic heterocyclic group consisting of 1 to 7 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (3) an optionally substituted C (4) an optionally substituted 5- to 14-membered aromatic fused heterocyclic group consisting of 3 to 11 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (5) an optionally substituted nonaromatic cyclic hydrocarbon group having a carbon number of not more than 7, and (6) an optionally substituted nonaromatic heterocyclic group having a carbon number of not more than 7, X is a group selected from the group consisting of (group (IV)), P is (1) a hydrogen atom, (2) any amino acid residues bound to each other contiguously or non-contiguously from the C-terminal side of the 1st-49th amino acid sequence of the amino acid sequence shown by SEQ ID NO: 67, (3) a group represented by the formula wherein J J J Q (i) an optionally substituted C (ii) an optionally substituted 5- to 14-membered aromatic heterocyclic group consisting of 1 to 7 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (iii) an optionally substituted C (iv) an optionally substituted 5- to 14-membered aromatic fused heterocyclic group consisting of 3 to 11 carbon atoms and a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (v) an optionally substituted nonaromatic cyclic hydrocarbon group having a carbon number of not more than 7, (vi) an optionally substituted nonaromatic heterocyclic group having a carbon number of not more than 7, (vii) optionally substituted amino, (viii) optionally substituted guanidino, (ix) optionally substituted hydroxy, (x) optionally substituted carboxyl, (xi) optionally substituted carbamoyl, and (xii) optionally substituted sulfhydryl or a hydrogen atom, J Q Y Z (4) a group represented by the formula wherein J J Q Y Z J (5) a group represented by the formula wherein J J Q Y Z J (6) a group represented by the formula J wherein J J Q Z J (7) a group represented by the formula J wherein J or a salt or prodrug thereof.