Patent ID: 8697384
Filing Date: 2014-04-15
Classification: G01N

Abstract:
1. A method for identifying the presence of an undiagnosed disease or disorder in a subject, said method comprising: i) determining the level of YKL-40 in a sample obtained from the subject; and ii) comparing said level of YKL-40 with a reference level of YKL-40 selected from the following set of age dependent cut-off values defined as: the 90th percentile: natural log(ln)(plasma YKL-40 μg/l)=3.5+0.02×age (years), the 95th percentile: ln(plasma YKL-40 μg/l)=3.6+0.02×age (years), and the 97.5th percentile: ln(plasma YKL-40 μg/l)=3.9+0.02×age (years), wherein the lower the percentile, the higher the sensitivity of the identification, and wherein a level of YKL-40 in the sample above one of said reference levels indicates the presence of the undiagnosed disease or disorder in the subject, thereby identifying the presence of the undiagnosed disease or disorder in the subject.