Patent ID: 7410966
Filing Date: 2008-08-12
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (Id) wherein: R Ar represents phenyl, a 5- or 6-membered heteroaromatic ring or an indole ring; said heteroaromatic ring incorporating 1 to 3 heteroatoms independently selected from O, N and S; R m represents an integer 1 or 2; and when m represents 2, each R n represents an integer 0 or 1; R R R being optionally further substituted by a 5 to 7 membered saturated azacyclic ring optionally incorporating one additional heteroatom selected from O, S and NR or the group —NR R R or the group —NR optionally substituted by one or more substituents selected independently from OH, NMe R R R R X represents O, S, a bond or NR Y represents C1 to 4 alkyl or a bond; Z represents: i) phenyl, naphthyl or a 5- or 6-membered heteroaromatic ring system containing one to three heteroatoms independently selected from O, N and S; or ii) a five- or six-membered saturated heterocyclic ring containing one or two heteroatoms independently selected from O, N and S; said ring optionally being benzo fused; or iii) C3 to 6 cycloalkyl; said ring Z being optionally substituted by one or more substituents independently selected from halogen, OH, C1 to 4 alkyl, C1 to 4 alkoxy, hydroxymethyl, methylsulphonyl and NR R Ar Ar said heteroaromatic ring incorporating 1 to 3 heteroatoms independently selected from O, N and S; said phenyl or heteroaromatic or benzimidazole ring being optionally further substituted by one or two groups independently selected from halogen, C1 to 4 alkyl, CN, CH Ar Ar Ar with the proviso that when R and Ar represents phenyl; then said phenyl is not substituted at the 4-position by C1 to 2 alkoxy, OH, halogen or C1 to 4 alkyl.