Patent ID: 6773895
Filing Date: 2004-08-10
Classification: C07K,G01N

Abstract:
A method for determining whether a substance inhibits or reduces an inflammatory process in which a macrophage is in a hyperactivated status due to a differentially expressed macrophage surface receptor, comprising: (a) applying said substance to a test system which generates a measurable read-out upon modulation of said macrophage surface receptor or macrophage surface receptor function, wherein said macrophage surface receptor is a FPRL-1 receptor comprising SEQ ID NO:2; and (b) comparing the level of the read-out of the test system to a control level, wherein a difference in levels indicates the substance is an inhibitor or an activator of said macrophage surface receptor; and wherein the inhibitor of the macrophage surface receptor which is expressed on a higher level in said hyperactived macrophage or the activator of the macrophage surface receptor which is expressed on a lower level in said hyperactived macrophage indicates the substance inhibits or reduces said hyperactivated status of said macrophage.