Patent ID: 6649622
Filing Date: 2003-11-18
Classification: A61P,C07D,C07F

Abstract:
A compound of formula I enantiomers, diastereomers, or pharmaceutically acceptable salts thereof wherein A is â€”R1, â€”(CR3R4)nâ€”R1, â€”R5(CR3R4)pâ€”R1, â€”(CR3R4)mR5(CR6R7)pâ€”R1, â€”(CR3R4)nR5(CR6R7)pâ€”R1, â€”S(O)R1, â€”S(O2)R1, or â€”NH(CR3R4)nâ€”R1; R1is substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl or cycloalkyl; B is â€”R2, â€”(CR3R4)nâ€”R2, â€”R5(CR3R4)pâ€”R2, â€”(CR3R4)mR5(CR6R7)pâ€”R2, â€”(CR3R4)n(CR6R7)pâ€”R2, â€”S(O)R2, â€”S(O2)R2, or â€”NH(CR3R4)nR2; R2 is aryl, substituted aryl, cycloalkylalkyl, heteroaryl or substituted heteroaryl; R3 and R4 are the same or different and are independently H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, arylcarbonyl, aryl and heteroaryl, halo, hydroxy, alkoxy and aryloxy; R5 is a bond, O, NR8, S, SO, SO2, CO or CONH; R6 and R7 are the same or different and are independently H, alkyl, cycloalkyl, aryl, hydroxy, amino, halo, alkoxy, aryloxy, alkylthio, arylthio, alkylamino, dialkylamino, arylamino, diarylamino, alkoxycarbonyl, alkylaminocarbonyl or alkylcarbonylamino; R8 is H, aryl, arylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkyl or alkylcarbonyl; R9 is H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; R11 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, cycloheteroalkyl and substituted cycloheteroalkyl; R12 and R13 are the same or different and are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; or R12 and R13 together with the nitrogen atom to which they are bonded together form an optionally substituted cycloheteroalkyl ring; X is selected from â€”Z, â€”(CR3R4)nâ€”Z, â€”Oâ€”(CR3R4)pâ€”Z, â€”Sâ€”(CR3R4)pâ€”Z, â€”NHC(&boxH;O)Z, â€”CH&boxH;CHZ, -(cycloalkylene)-Z, or â€”N(R8)(CR3R4)nâ€”Z; Y is hydrogen, OH, or â€”(CR3R4)nâ€”CO2R9, or X and Y taken together with the atom to which they are joined provide a group of the formula â€ƒZ is CO2R9, CONR12R13, PO3H2, CONHOH, or tetrazole of the formula â€ƒor its tautomer; n is an integer selected from 0 to 5; m is an integer selected from 1 to 5; and p is an integer selected from 0 to 4.