Patent ID: 6019957
Filing Date: 2000-02-01
Classification: A61K,C07B,C07C,C07D

Abstract:
A radiolabeled non-steroidal compound having the formula: ##STR62## where R.sub.1, R.sub.2 and R.sub.3, are the same or different and are a radioactive or nonradioatctive halogen, a nitro, a cyano, a carbamoyl, a hydrogen, a perfluoroalkyl, a haloalkylamido, an isothiocyanate, an azide, a diazocarbonyl, a substituted oxirane, or a .beta.-chloroethylamine;R.sub.4 is a hydrogen, an alkyl, or is joined to R.sub.5 ;R.sub.5 is a radioactive or nonradioactive halogen, a hydrogen, a hydroxy, an alkyl, a haloalkyl, an alkoxy, an acyloxy, an amino, an alkylamino, a thio, a thioalkyl, or is joined to R.sub.4 to form a five-membered ring optionally containing a hetero-atom as a ring member;R.sub.6 is a hydrogen, an alkyl, a halogen, or a haloalkyl;A.sub.1 and A.sub.2 are the same or different, and each is a direct link or an alkylene;X.sub.1 is an oxygen, a sulfur, a sulphinyl, a sulphonyl, an alkylimino, or alkylene;R.sub.7 is a radioactive or nonradioactive halogen, a hydrogen, an aloxy, a haloalkoxy, an acyloxy, a haloacyloxy, an aryloxy, a thioalkyl, a thioraryl, an alkylsulphinyl, an arylsulphinyl, an alkylsulphonyl, an arylsulphonyl, an amino, an alkylimino, an alkylamido group, a radioactive or nonradioactive, haloalkylamido group, a phenyl optionally substituted with a radioactive or nonradioactive halogen, a nitro group, an alkyl, a radioactive or nonradioactive haloalkyl, a cyano, a hydroxyl, a caboxyl group, an amino, an alkylamino group, a dialkylamino group, a bisalkylamino group, a radioactive or nonradiactive haloalkylamino group, a radioactive or nonradioactive dihaloalkylamino group, a radioactive or nonradioactive bishaloalkylamino group, an acylamido group, a diacylamido group, an alkylacylamido group, a radioactivc or nonradioactive haloacylamido group, a radioactive or nonradiactive bis(haloacyl)imido group, or a radioactive or nonradioactive alkyhaloacylamido group.