Patent ID: 7915388
Filing Date: 2011-03-29
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A binding protein comprising an antigen binding domain, said binding protein capable of binding IL-13, said antigen binding domain comprising six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, wherein: CDR-H1 is selected from the group consisting of: X residues 31-35 of SEQ ID NO:32; residues 31-35 of SEQ ID NO:34; residues 31-35 of SEQ ID NO:36; residues 31-35 of SEQ ID NO:38; residues 31-35 of SEQ ID NO:39; residues 31-35 of SEQ ID NO:41; residues 31-35 of SEQ ID NO:42; residues 31-35 of SEQ ID NO:44; residues 31-35 of SEQ ID NO:52; residues 31-35 of SEQ ID NO:54; residues 31-35 of SEQ ID NO:56; residues 31-35 of SEQ ID NO:58; residues 31-35 of SEQ ID NO:60; and residues 31-35 of SEQ ID NO:62; CDR-H2 is selected from the group consisting of: X residues 50-65 of SEQ ID NO:44; residues 52-67 of SEQ ID NO:46; residues 52-67 of SEQ ID NO:48; residues 52-67 of SEQ ID NO:50; residues 50-65 of SEQ ID NO:54; residues 50-65 of SEQ ID NO:56; residues 50-65 of SEQ ID NO:58; residues 50-65 of SEQ ID NO:60; and residues 50-65 of SEQ ID NO:62; CDR-H3 is selected from the group consisting of: X residues 99-105 of SEQ ID NO:32; residues 99-105 of SEQ ID NO:34; residues 99-109 of SEQ ID NO:36; residues 99-109 of SEQ ID NO:38; residues 99-100 of SEQ ID NO:42; residues 98-106 of SEQ ID NO:44; residues 100-112 of SEQ ID NO:46; residues 100-112 of SEQ ID NO:48; residues 100-112 of SEQ ID NO:50; residues 99-107 of SEQ ID NO:52; residues 98-107 of SEQ ID NO:54; residues 98-107 of SEQ ID NO:56; residues 98-107 of SEQ ID NO:58; residues 98-107 of SEQ ID NO:60; and residues 98-107 of SEQ ID NO:62; CDR-L1 is selected from the group consisting of: X residues 24-39 of SEQ ID NO:33; residues 24-39 of SEQ ID NO:35; residues 24-39 of SEQ ID NO:37; residues 24-39 of SEQ ID NO:40; residues 24-39 of SEQ ID NO:43; residues 24-34 of SEQ ID NO:47; residues 24-34 of SEQ ID NO:49; residues 24-34 of SEQ ID NO:51; residues 23-36 of SEQ ID NO:53; residues 24-38 of SEQ ID NO:55; residues 24-38 of SEQ ID NO:57; residues 24-38 of SEQ ID NO:59; residues 24-38 of SEQ ID NO:61; and residues 24-38 of SEQ ID NO:63; CDR-L2 is X and CDR-L3 is selected from the group consisting of: X residues 94-102 of SEQ ID NO:40.