Patent ID: 9028810
Filing Date: 2015-05-12
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of treating a glioma the method comprising: (a) administering to the area around the glioma a periostin-overexpressing and over-secreting cell transfected by the periostin gene, wherein the transfected cell is a fibroblast or HEK cell; (b) administering to the area around the glioma a human neural stem cells transfected with a cytosine deaminase gene, wherein the neural stem cells express cytosine deaminase; (c) administering to the area around the glioma 5-fluorocytosine, wherein the cytosine deaminase converts the 5-fluorcytosine to 5-fluoruracil; wherein the oversecreted periostin enhances targeting of the human neural stem cells, and wherein the 5-fluorouracil is in an amount that will kill glioma cells.