Patent ID: 8470307
Filing Date: 2013-06-25
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A method for inhibiting acute myeloid leukemia (AML) cells in a human diagnosed with AML, comprising administering to a human in need of such inhibition a pharmaceutical composition comprising a human interleukin-3 (IL-3)-diphtheria toxin conjugate in which the conjugate is administered at a dose greater than 4 μg/kg to about 20 μg/kg, wherein (i) said inhibition results in inhibition of the growth of AML cells, a reduction in the proliferation of AML cells, a stabilization in the amount of AML cells, a reduction in the amount of AML cells, a reduction in the amount of IL-3R-expressing AML cells, a stabilization in the amount of blasts, a reduction in the amount of blasts, an improvement in hematopoietic function, and/or an improvement in the marrow blast index; (ii) the conjugate is administered once every day for five days, the conjugate is administered at least two times a week, the conjugate is administered at least three times a week, or the conjugate is administered over a period of two weeks or more; and (iii) the AML is refractory, the human is in a state of remission from the AML, the human has been previously treated with a therapeutic agent and/or has undergone radiation therapy, the human is currently being administered a therapeutic agent and/or is undergoing radiation therapy, the human has relapsed from AML, the human has failed AML treatment, the human is susceptible to adverse reactions from other AML therapies, the human is refractory to chemotherapy, or the human has not been previously treated for AML.