Patent ID: 7763754
Filing Date: 2010-07-27
Classification: C07B,C07C

Abstract:
1. A process for producing (1R,3R,6R)-6-dimethylaminomethyl- 1-(3-methoxyphenyl)-cyclohexane-1,3-diol, (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclo-hexane-1,3-diol, a mixture thereof, or an acid addition salt thereof, said process comprising: reacting 3-dimethylamino-1-(3-methoxyphenyl)-propan-1-one (II) with an α,β-unsaturated ketone to form 2-dimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione (III) and cyclizing the 2-dlimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione (III) to form 4-dimethylaminomethyl-3-hydroxy-3-(3-methoxyphenyl)cyclohexanone (IV)