Patent ID: 7666867
Filing Date: 2010-02-23
Classification: A61P,C07D

Abstract:
1. A compound of formula I below, and physiologically acceptable salts: wherein, R1 is -Q-Z; Q is an optionally present alkyl group having 1 to about 7 carbon atoms if present; Z is, in any possible position, any possible member selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group independently substituted on at least one available ring nitrogen atom by at least one of an alkyl group, a benzyl group, a lower-alkoxybenzyl group, a benzhydryl group, a substituted benzhydryl group, a phenyl group, a substituted phenyl group, a methylbenzyl group, a substituted methylbenzyl group; or any above group substituted on at least one available ring carbon atom by an alkyl group and independently substituted on at least one available ring nitrogen atom by at least one of an alkyl group, a benzyl group, a lower-alkoxybenzyl group, a benzhydryl group, a substituted benzhydryl group, a phenyl group, a substituted phenyl group, a methylbenzyl group, a substituted methylbenzyl group; and wherein the connecting point to the Z group can be any possible ring atom; or Z is, in any possible position, any possible member selected from a heterocyclic ring having about 4 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a heterobicyclic ring, a heterotricyclic ring, a heteropolycyclic ring; or any above group comprising a substituent group on at least one available ring atom; and wherein the connecting point to the Z group can be any possible ring atom; or Z is, in any possible position, any possible member selected from R2 is X-Z; X is selected from C(O), C(O)O, OC(O)O, NC(O)O, C(O)NT, NTC(O), OC(O)NT, C(O)NTT, C(O)NTNT, NTC(O)NT, T is selected from H, an alkyl group consisting of 1 to about 4 C atoms, a heteroalkyl group consisting of 1 to about 4 C atoms, a carbocyclic ring having about 4 to about 7 ring members, or any above group having a substituent group on at least one available ring atom; wherein the variable T can not be substituted with a heteroaryl, heteroaromatic, or heterocyclic group; Z is, in any possible position, any possible member selected from an adamantyl group, a tricyclic ring, a polycyclic ring; piperidine, or any above group consisting of a substituent group on at least one available ring atom; and wherein the connecting point to the Z group can be any possible ring atom; wherein X and Y in the Z structure are each independently selected from H, halogen, N and the variable X and Y, is not and can not be substituted with a heteroaryl, heteroaromatic, or heterocyclic; and R3 is a substituent at any or all of the possible 4-, 5-, 6- and/or 7-positions, wherein each substituent is independently selected from H, halogen, N wherein R