Patent ID: 8114442
Filing Date: 2012-02-14
Classification: A61K,A61P,Y02A

Abstract:
1. A method for delivering a pharmaceutically active agent to a patient in need of such agent, comprising at least the following steps: administering to the patient a topically-applied nitric oxide (NO)-generating system, wherein the system consists of a pharmacologically acceptable acidifying agent in aqueous combination with a nitrite selected from the group consisting of an alkali metal nitrite, an alkaline earth metal nitrite and a nitrite precursor therefor, thereby effecting a topical reaction on and in the patient's skin at the site of administration; and administering the pharmaceutically-active agent to the patient, whereby NO generated by the system facilitates direct transdermal delivery of the pharmaceutically-active agent to the patient within <10 minutes from the time of administration, such that said delivered agent is in an amount sufficient to achieve a statistically significantly greater response thereto in the patient than the response achieved by application of the agent alone.