Patent ID: 6171788
Filing Date: 2001-01-09
Classification: A61P,C07K,C12Q

Abstract:
A method for diagnosing glaucoma in a sample obtained from a cell or a bodily fluid by detecting mutants in the promoter region of the TIGR gene, comprising the steps of:(A) incubating under conditions permitting nucleic acid hybridization, a marker nucleic acid molecule, said marker nucleic acid molecule having a nucleic acid sequence that specifically hybridizes to a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO:5, and the complements thereof, and a complementary nucleic acid molecule obtained from a sample, wherein nucleic acid hybridization between said marker nucleic acid molecule and said complementary nucleic acid molecule permits the detection of a polymorphism;(B) permitting hybridization between said marker nucleic acid molecule and said complementary nucleic acid molecule; and(C) detecting the presence of said polymorphism, wherein the detection of said polymorphism is diagnostic of glaucoma.