Patent ID: 8889672
Filing Date: 2014-11-18
Classification: A61K,A61P

Abstract:
1. A method of inhibiting or reducing vascular permeability comprising: administering to a subject in need thereof a composition comprising a compound in an amount effective to inhibit or reduce vascular permeability, the compound having a structure selected from the group consisting of structural formula (I) to (VIII): structural formula (I): structural formula (II): structural formula (III): structural formula (IV): structural formula (V): structural formula (VI): structural formula (VII): and structural formula (VIII): wherein X wherein n has a value of zero (0), one (1), or two (2); wherein R wherein R wherein X wherein R wherein R wherein R wherein Ar is selected from the group consisting of phenyl, napthyl, pyridyl, pyrrolidyl, furanyl, pyranyl, azepinyl, oxepinyl, imidizolyl, oxazolyl, pyrimidinyl, purinyl, dimethoxyphenyl, chlorophenyl, dichlorophenyl, bromophenyl, hydroxyphenyl, trimethylphenyl, fluorophenyl, nitrophenyl, methoxyphenyl, dihydrobenzopyran, pyridine, dimethyl aminophenyl, aminophenyl, piperonyl, fluoromethoxyphenyl, acetamidophenyl, and carbomoylphenyl; wherein R wherein when either R wherein the compound is not isopropyl 2-amino-4-(3,4-dichlorophenyl)thiophene-3-carboxylate.