Patent ID: 7176234
Filing Date: 2007-02-13
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating or ameliorating a disorder responsive to the induction of apoptosis in an animal suffering therefrom, with reduced side effects at the site of administration and reduced systemic toxicity, comprising administering to a mammal in need of such treatment an effective amount of a compound having one of the Formulae I–II: or pharmaceutically acceptable salts or prodrugs thereof, wherein: the dotted lines are single bonds, double bonds or an epoxy group; X together with the attached carbon is a methylene, carbonyl, hydroxymethinyl, alkoxymethinyl, aminomethinyl, an oxime, a hydrazone, an arylhydrazone or semicarbazone; Y together with the attached carbon is a methylene, carbonyl, hydroxymethinyl, alkoxymethinyl, aminomethinyl, an oxime, a hydrazone, an arylhydrazone or semicarbazone; R R R R R said compound causes no side effects at the site of administration; wherein said disorder responsive to the induction of apoptosis is inflammation, inflammatory bowel disease, psoriasis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, Hashimoto's thyroiditis, autoimmune lymphoproliferative syndrome, or a cancer selected from the group consisting of Hodgkin's disease, non-Hodgkin's lymphoma, acute and chronic lymphocytic leukemias, multiple myeloma, neuroblastoma, breast carcinoma, ovarian carcinoma, lung carcinoma, Wilms' tumor, cervical carcinoma, testicular carcinoma, soft-tissue sarcoma, chronic lymphocytic leukemia, primary macroglobulinemia, bladder carcinoma, chronic granulocytic leukemia, primary brain carcinoma, malignant melanoma, small-cell lung carcinoma, stomach carcinoma, colon carcinoma, malignant pancreatic insulinoma, malignant carcinoid carcinoma, choriocarcinoma, mycosis fungoides, head and neck carcinoma, osteogenic sarcoma, pancreatic carcinoma, acute granulocytic leukemia, hairy cell leukemia, neuroblastoma, rhabdomyosarcoma, Kaposi's sarcoma, genitourinary carcinoma, thyroid carcinoma, esophageal carcinoma, malignant hypercalcemia, cervical hyperplasia, renal cell carcinoma, endometrial carcinoma, polycythemia vera, essential thrombocytosis, adrenal cortex carcinoma, skin cancer and prostatic carcinoma.