Patent ID: 8828951
Filing Date: 2014-09-09
Classification: A61K,A61P,C07D,C07H

Abstract:
1. A method of treating a disease or condition mediated by the sodium D-glucose co-transporter in a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of a compound represented by Formula (I): wherein: Ring A is an C6-10aryl which is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, cyano, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, haloC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, haloC1-6alkyl, C6-10aryl, C6-10arylC1-4alkyl, —C(O)OR3, —C(O)R3, —C(O)NR4R5, —NR4R5, —CH2NR4R5, C1-6alkoxy, C3-7 cycloalkoxy, —S(O)pR3, —S(O)2NR4R5, —OS(O)2R3, —CH2C(O)OR3, —CH2C(O)NR4R5, —NR3C(O)NR4R5, —NR3C(O)OR3, C6-10aryloxy, C2-10heterocyclyl, C2-10heterocyclylC1-4alkyl, C1-10heteroarylC1-4alkyl, C1-10heteroaryl, C1-10heteroaryloxy and C1-10heterocycloxy; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl and heteroaryl groups may be optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, cyano, nitro, C1-6alkyl, —S(O)pR3, —C(O)OR3, —C(O)R3, —C(O)NR4R5, —NR4R5, —CH2NR4R5 and C1-6alkoxy; Ring A′ is a 5-, 6- or 7-membered heterocycle, provided that Ring A′ is not 1,3-dioxole; Ya is a bond or a (C1-C6)alkylene which is optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyl, C1-4alkoxy, haloC1-4alkyl; V is hydrogen, halo or —OR1b; n is 0, 1, 2, or 3; q is 0, 1, 2, or 3; R1, R1a, R1b and R1c are independently selected from hydrogen, C1-6 alkyl, C6-10aryl-C1-4alkyl, —C(O)C6-10aryl and —C(O)C1-6alkyl; R2, for each occurrence, is independently selected from the group consisting of halo, hydroxy, cyano, nitro, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C6-10aryl, C6-10arylC1-4alkyl, —C(O)OR3, —C(O)R3, —C(O)NR4R5, —NR4R5, —CH2NR4R5, C1-6alkoxy, C3-7 cycloalkoxy, —S(O)pR3, —S(O)2NR4R5, —OS(O)2R3, —CH2C(O)OR3, —CH2C(O)NR4R5, —NR3C(O)NR4R5, —NR3C(O)OR3, C6-10aryloxy, C2-10heterocyclyl, C2-10heterocyclylC1-4alkyl, C1-10heteroarylC1-4alkyl, C1-10heteroaryl, C1-10heteroaryloxy and C1-10heterocycloxy; wherein when any portion of R2 is an alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, for each occurrence, it may be optionally substituted with one or more substituents which are independently selected from halo, hydroxy, C1-4alkyl, and C1-4alkoxy; R2a, for each occurrence, is independently selected from the group consisting of oxo, halo, hydroxy, cyano, nitro, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C6-10aryl, C6-10arylC1-4alkyl, —C(O)OR3, —C(O)R3, —C(O)NR4R5, —NR4R5, —CH2NR4R5, C1-6alkoxy, C3-7 cycloalkoxy, —S(O)pR3, —S(O)2NR4R5, —OS(O)2R3, —CH2C(O)OR3, —CH2C(O)NR4R5, —NR3C(O)NR4R5, —NR3C(O)OR3, C6-10aryloxy, C2-10heterocyclyl, C2-10heterocyclylC1-4alkyl, C1-10heteroarylC1-4alkyl, C1-10heteroaryl, C1-10heteroaryloxy and C1-10heterocycloxy; wherein when any portion of R2a is an alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, for each occurrence, it may be optionally substituted with one or more substituents which are independently selected from halo, hydroxy, cyano, nitro, C1-6alkyl, —S(O)pR3, —C(O)OR3, —C(O)R3, —C(O)NR4R5, —NR4R5, —CH2NR4R5 and C1-6alkoxy; or two R2a on adjacent atoms taken together with the atoms to which they are attached may form a fused C3-7cycloalkyl, C6aryl, 3- to 7-membered heterocyclyl, or 5- or 6-membered heteroaryl, wherein the fused cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one or more substituent independently selected from halo, hydroxy, C1-4alkyl, and C1-4alkoxy; or two R2a on the same carbon atom taken together may form a spiro 3- to 7-membered heterocyclyl or a spiro C3-7cycloalkyl which may be optionally substituted with one or more substituent independently selected from halo, hydroxy, C1-4alkyl, and C1-4alkoxy; and R3, for each occurrence, is independently selected from hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4alkyl, C6-10aryl, C1-10heteroaryl, and C2-10heterocyclyl; X is [C(R6)(R7)]t; Y is H, halo, C1-4 alkyl, OR1c or NR4R5; t is 1, 2, or 3; R6 and R7, for each occurrence, are independently selected from hydrogen, C1-6 alkyl, OR1e, and NR4R5; or when t is 1, R6 and R7 together may form an oxo group, or when R6 and R7 are on the same carbon they can be taken together to form a C3-7cycloalkyl or a 3- to 7-membered heterocycle; R1e, for each occurrence, is independently selected from hydrogen, C1-6 alkyl, C6-10aryl-C1-4alkyl, —C(O)C6-10aryl and —C(O)C1-6alkyl; R4 and R5, for each occurrence, are independently selected from hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4alkyl, C6-10arylC1-4alkyl, C6-10aryl, C1-10heteroaryl, C1-10heteroarylC1-4alkyl, C2-10heterocyclyl, and C2-10heterocyclylC1-4alkyl; or R4 and R5 taken together along with the nitrogen to which they are bound may form a monocyclic or a bicyclic heteroaryl or heterocyclyl which may be optionally substituted with one or more halo or C1-4alkyl; or a pharmaceutically acceptable salt thereof, wherein the disease or condition is selected from the group consisting of dyslipidemia, obesity, insulin resistance, hypertension, microalbuminemia, hyperuricaemia and hypercoagulability.