Patent ID: 7696338
Filing Date: 2010-04-13
Classification: A61K,C07K

Abstract:
1. A nucleic acid encoding an anti-T cell immunotoxin fusion protein, comprising, from the amino terminus, a truncated diphtheria toxin moiety, a connector, and two single chain Fvs of the variable region of a UCHT1 antibody, wherein the two single chain Fvs comprise VL, L, VH, L, VL, L, VH, wherein L is a Gly-Ser linker, wherein the diphtheria toxin moiety contains the first 390 amino acids of the native toxin, wherein VL and VH are the variable light and heavy domains of the anti-CD3 antibody UCHT1, and wherein the nucleic acid comprises the nucleic acid sequence of SEQ ID NO:30.