Patent ID: 8211897
Filing Date: 2012-07-03
Classification: A61K,A61P

Abstract:
1. A method of treating diseases mediated by Cathepsin B in a mammal, wherein the diseases mediated by Cathepsin B are selected from the group consisting of Alzheimer's Disease, arthritis, muscular dystrophy, inflammation, glomerulonephritis, periodontal disease, metachromatic leukodystrophy, tumor invasion, metastasis, chronic and acute pancreatitis, inflammatory airway disease, osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, fibrotic disease, steatosis, non-alcoholic steatohepatitis, alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, pulmonary fibrosis, idiopathic pulmonary fibrosis, renal fibrosis, cardiac fibrosis, retinal angiogenesis, fibrosis/gliosis in the eye, scleroderma, and systemic sclerosis comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein E is a member selected from the group consisting of —COCONR R X is a member selected from the group consisting of —O—, —NR R Y is a member selected from the group consisting of —C(O)NH—,—OC(O)NH—, —NR R R a pharmaceutically acceptable salt thereof.