Patent ID: 6794490
Filing Date: 2004-09-21
Classification: A61K,A61P,C07K

Abstract:
A compound having the formula (I): or a salt thereof;wherein R and R1 are independently: wherein X and Xâ€² are independently selected from the group consisting of C&boxH;O, C&boxH;S, C&boxH;NH, C&boxH;NRX, S&boxH;O and SO2;wherein n is 0 or 1; wherein RX is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, hydroxyl, alkoxy, carboxy and carboalkoxy; wherein B is Xâ€²RY, H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyl; wherein RY is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl and hydroxyl; wherein A is H, NH2, NHRA, NRARB, alkyl, alkenyl, alkynyl, alkoxy, aryloxy, aryl, heteroaryl, cycloalkyl, or heterocyclyl; wherein RA and RB are independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl and carboalkoxy; or wherein when n is 0, then A is additionally selected from the group consisting of: wherein each of R50-R53 is independently selected from C1-C15 alkyl; alternatively, wherein B and A together form a 5-7 membered heterocyclic or heteroaryl ring; and wherein R2 is wherein K and Kâ€² together form a C3-C7 cycloalkyl or heterocyclyl ring or a C5-C10 aryl or heteroaryl ring; wherein J is selected from the group consisting of hydrido, amino, NHRJ, NRJRK, alkyl, alkenyl, alkynyl, alkoxy, aryloxy, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkylamino, hydroxyl, thio, alkylthio, alkenylthio, sulfinyl, sulfonyl, azido, cyano, halo, wherein each of R24, R25, and R26 is independently selected from the group consisting of alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl; or R24 and R25 together form a 5-8 membered heterocyclyl ring; wherein RJ and RK are independently selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyl; or alternatively, wherein J, together with R17, forms a 5-8 membered heterocyclyl or cycloalkyl, ring; or alternatively, J, together with both R17 and R18, forms a 5-8 membered aryl, cycloalkyl, heterocyclyl or heteroaryl ring; wherein each of R17 and R18 is independently selected from the group consisting of hydrido, halo, hydroxyl, alkoxy, amino, thio, sulfinyl, sulfonyl and orwherein R17 and R18 taken together form a substituent selected from the group consisting of ketal, thioketal, wherein each of R22 and R23 is independently selected from the group consisting of hydrido and alkyl; provided that when K and Kâ€² are together form a phenyl ring and R17 and R18 taken together form C&boxH;O, then J is not NH2, C4-C14 alkylidenyl, or NHRQ, wherein RQ is C4-C14 unsubstituted alkyl, substituted or unsubstituted C2-C19 alkanoyl, unsubstituted C5-C19 alkenoyl, benzyloxycarbonyl, or carboalkoxy.