Patent ID: 8349883
Filing Date: 2013-01-08
Classification: A61P,C07D

Abstract:
1. A method for the treatment of brain cancer, kidney cancer, liver cancer, adrenal gland cancer, bladder cancer, stomach cancer, esophagus cancer, ovarian cancer, colon cancer, rectum cancer, prostate cancer, pancreas cancer, lung cancer, vagina cancer, thyroid cancer, sarcoma, glioblastoma, multiple myeloma, gastrointestinal cancer, breast cancer, lymphoma or leukemia comprising administration to a mammal in need of treatment thereof an effective amount of a compound according to Formula I: or a pharmaceutically acceptable salt or ester thereof, wherein: Y and Z independently are a) -L-, b) -L-O-L-, c) -L-S(O) L, at each occurrence, is a) a divalent C R R R R R R R R L′, at each occurrence, is a) a divalent C