Patent ID: 6881753
Filing Date: 2005-04-19
Classification: A61P,C07C,C07D

Abstract:
1. A compound having the structure: or pharmaceutically acceptable salts thereof, prodrug esters thereof, or all stereoisomers thereof, wherein A, B and D are each —CH or N; where n is 1, 2 or 3, and where R 3 and R 4 are independently H, alkyl, arylalkyl or cycloalkyl, or R 3 and R 4 can be taken together with the carbon to which they are attached to form a 5 to 8 carbon containing ring; R is H, alkyl, alkenyl, aryl, arylalkyl, heterocycloalkyl, cycloalkyl, or cycloalkylalkyl; R where R 5a is selected from H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl or (where R 6 and R 7 are independently selected from H, aryl, alkyl, arylalkyl or cycloalkyl, or R 6 and R 7 can be taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered ring); or R and R 1 can be taken together with the —N—S— atoms to form a 5- to 8-membered ring; X or —O— (where R 8 is H, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl); R (where R 10 and R 11 are independently selected from H, alkyl, arylalkyl or cycloalkyl, or R 10 and R 11 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring); and Q is (where R 12 is alkyl, arylalkyl, aryl, heterocycle, heterocycloalkyl, where R 15 and R 16 are independently selected from H, alkyl, arylalkyl, aryl, heterocyclo, cycloalkyl, amino, aminoalkyl, or heterocycloalkyl, or R 15 and R 16 can be taken together with the nitrogen to which they are attached to form a 5- to 8-membered ring which may optionally contain an additional nitrogen atom in the ring and/or an amino group or an aminoalkyl group attached to the ring).