Patent ID: 6747136
Filing Date: 2004-06-08
Classification: A61K,A61P,C07K

Abstract:
An isolated nucleic acid molecule encoding a human Fab molecule, wherein the nucleic acid molecule comprises:a first nucleotide sequence encoding a first polypeptide that is a binding portion of a &ggr;1 heavy chain variable region (VH) of said human Fab molecule where said heavy chain region exhibits immunological binding affinity for a hepatitis C Virus (HCV) E2 antigen; and wherein the first polypeptide comprises a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6 and SEQ ID NO:7; and a second nucleotide sequence encoding a second polypeptide that is a binding portion of a &kgr; light chain variable region (VK) of said human Fab molecule where said light chain variable region exhibits immunological binding affinity for a hepatitis C virus (HCV) E2 antigen, and wherein the second polypeptide comprises a sequence selected from the group consisting of SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13 and SEQ ID NO:14, and wherein said Fab molecules have binding affinity greater than 1Ã—107 Mâˆ’1 for HCV E2.