Patent ID: 9221919
Filing Date: 2015-12-29
Classification: A61K,C07F,C07K,C08G,G01N,Y10S

Abstract:
1. A functionalized probe nanostructure comprising: a nanocrystalline body capable of exposing free surface hydroxyls defining an outer surface and being formed of a crystal material, the crystal material having an internal crystal structure having a unit cell having no inversion symmetry such that the crystal material generates a second harmonic signal independent of the overall shape of the nanocrystalline body when illuminated by an external excitation source, a functionalization platform comprising a plurality of modifying molecules having amine terminal groups, the modifying molecules being linked to the outer surface of the nanocrystalline body through a plurality of hydroxyl molecules; and a plurality of functionalization molecules bound to the amine terminal groups of the functionalization platform.