Patent ID: 6759415
Filing Date: 2004-07-06
Classification: A61P,C07D

Abstract:
A compound of the formula in racemic, enantiomeric form or all combinations of these forms,R1 is selected from the group consisting of (C1-C12)alkyl, (C0-C6)alkyl-C(O)â€”Oâ€”Z1, (C0-C6)alkyl-C(O)â€”NHâ€”(CH2)pâ€”Z2 and unsubstituted or substituted aryl, Z1 is selected from the group consisting of H, (C1-C6)alkyl and â€”(CH2)p-aryl; Z2 is selected from the group consisting of amino, (C1-C12)alkylamino, (C3-C8)cycloalkylamino, N,N-di-(C1-C12)alkylamino, NHâ€”Câ€”(O)â€”Oâ€”(CH2)p-phenyl, NHâ€”C(O)â€”Oâ€”(CH2)pâ€”(C1-C6)alkyl, an unsubstituted or substituted carbocyclic or heterocyclic aryl and unsubstituted or substituted heterocyclic non-aromatic; R2 is selected from the group consisting of H, (C1-C12)alkyl and aryl optionally substituted; R3 is H or (CH2)pâ€”Z3; Z3 is selected from the group consisting of (C1-C12)alkyl, (C1-C12)alkenyl, (C3-C8)cycloalkyl, Y1â€”(CH2)p-phenyl-(X1)n, â€”Sâ€”(C1-C12)alkyl, Sâ€”(C1-C12)alkyl-Sâ€”Sâ€”(C1-C12) alkyl, and unsubstituted or substituted carbocyclic or heterocyclic aryl; Y1 is O, S, NH or is absent; R4 is (CH2)pâ€”Z4; Z4 is selected from the group consisting of amino, (C1-C12)alkyl, (C3-C8)cycloalkyl, (C1-C12)alkylamino, N,N-di-(C1-C12)alkylamino, amino(C3-C6)cycloalkyl, amino(C1-C6)alkyl(C3-C8)cycloalkyl(C1-C6)alkyl, carbocyclic or heterocyclic aminoaryl, (C1-C12)alkoxy, (C1-C12)alkenyl, Nâ€”C(O)O(C1-C6)alkyl, unsubstituted or substituted carbocyclic or heterocyclic aryl, unsubstituted or substituted heterocyclic non-aromatic radical, bis-arylalkyl, di-arylalkyl, â€ƒand N(R6)(R7), R6 and R7 taken together with the nitrogen atom which they carry form together a heterocycle of 5 to 7 ring members; R5 is selected from the group consisting of H, â€”(CH2)pâ€”C(O)â€”(CH2)pâ€”Z5, â€”(CH2)pâ€”Z5, â€”(CH2)pâ€”OZ5 or â€”(C0-C6)alkyl-C(O)â€”NHâ€”(CH2)pâ€”Z5, Z5 is unsubstituted or substituted member selected from the group consisting of â€”(C1-C12)alkyl, benzo[b]thiophene, phenyl, naphthyl, benzo[b]furannyl, thiophene, isoxazolyl, indolyl, â€ƒit being understood that a substituted radical is substituted by at least one member of the group consisting of Cl, F, Br, I, CF3, NO2, OH, NH2, CN, N3, â€”OCF3, (C1-C12)alkyl, (C1-C12)alkoxy, â€”(CH2)p-phenyl-(XI)q, â€”NHâ€”COâ€”(C1-C6)alkyl, â€”NHâ€”C(O)Oâ€”(C1-C6)alkyl, â€”Sâ€”(C1-C6)alkyl, â€”S-phenyl-(X1)q, â€”Oâ€”(CH2)p-phenyl-(X1)q, â€”(CH2)pâ€”C(O)â€”Oâ€”(C1-C6)alkyl, â€”(CH2)pâ€”C(O)â€”(C1-C6)alkyl, â€”Oâ€”(CH2)pâ€”NH2, â€”Oâ€”(CH2)pâ€”NHâ€”(C1-C6)alkyl, â€”Oâ€”(CH2)pâ€”N-di((C1-C6)alkyl) and ((C0-C12)alkyl-(X1)q; X1, each time that it occurs, is independently selected from the group consisting of H, Cl, F, Br, I, CF3, NO2, OH, NH2, CN, N3, â€”OCF3, (C1-C12)alkyl, (C1-C12)alkoxy, â€”Sâ€”(C1-C6)alkyl, â€”(CH2)p-amino, â€”(CH2)pâ€”NHâ€”(C1-C6)alkyl, â€”(CH2)pâ€”N-di-((C1-C6)alkyl), â€”(CH2)p-phenyl and â€”(CH2)pâ€”NHâ€”(C3-C6)-cycloalkyl; p each time that it occurs is independently an integer from 0 to 6; q each time that it occurs is independently an integer from 1 to 5; X is O or S; n is 1; and m is 0 or 1 and its pharmaceutical salts.