Patent ID: 6093816
Filing Date: 2000-07-25
Classification: A61K,C07D,C07K,Y10T

Abstract:
A compound having the structure A ##STR18## wherein each R is independently hydrogen or a lipophilic moiety, provided that both R are not hydrogen;R.sup.1 and R.sup.2 are independently hydrogen, --(CH.sub.2).sub.z --N(R.sup.4).sub.2, --(CH.sub.2).sub.z NR.sup.4 --C(NH)--N(R.sup.5).sub.2, or W.sup.1, provided that at least one of R.sup.1 and R.sup.2 is W.sup.1 ;each R.sup.3 is independently hydrogen, alkyl (C.sub.1-10), --CH.sub.2 --(CF.sub.2).sub.p --CF.sub.3, aryl, a protecting group, or both R.sup.3 together are a protecting group, or one R.sup.3 is hydrogen and the other R.sup.3 is --C(O)CH.sub.2 NH.sub.2 or --C(O)CHCH.sub.3 NH.sub.2, provided that both R.sup.3 are not aryl;each R.sup.4 is independently hydrogen, alkyl (C.sub.1-6), a protecting group, --CH.sub.2 --(CF.sub.2).sub.p --CF.sub.3, or both R.sup.4 together are a protecting group;each R.sup.5 is independently hydrogen, alkyl (C.sub.1-6), a protecting group, or both R.sup.5 together are a protecting group;each W.sup.1 is independently a cationic group, at least one of which has a pKa of about 6.0-7.5;m is an integer having the value 0, 1, 2, 3 or 4;n is an integer having the value 0, 1, 2, 3 or 4;p is an integer having the value 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;s is an integer having the value 0, 1 or 2;z is an integer having the value 1, 2, 3, or 4;positions designated * are carbon atoms in the R, S or RS configuration; orthe salts, tautomers, solvates, resolved, partially resolved or unresolved enantiomers, purified, partially purified or unpurified positional isomers or diastereomers thereof.