Patent ID: 6815187
Filing Date: 2004-11-09
Classification: A61K,C07K

Abstract:
A method for stimulating angiogenesis within viable cells, tissues, organs in-situ, said method comprising:identifying a viable endothelial cell in-situ as a target, said targeted endothelial cell bearing a plurality of transmembrane syndecan-4 proteoglycans positioned at and through the cell surface wherein the 183rd amino acid reside present within the intracellular cytoplasmic domain of said sydecan-4 proteoglycan is a serine residue, administering to said targeted endothelial cell on at least one occasion a predetermined amount of a chemical inhibitor effective against Protein Kinase C &dgr; (delta) isoenzyme activity such that said 183rd serine residue within the cytoplasmic domain of at least some of said syndecan-4 proteoglycans is present in a non-phosphorylated state; and allowing said 183rd serine residue within the cytoplasmic domain of said syndecan-4 proteoglycans to continue to be present in a non-phosphorylated state, whereby a stimulation of angiogenesis in-situ results.