Patent ID: 7427598
Filing Date: 2008-09-23
Classification: A61K,A61P,C07K

Abstract:
1. A method for improving learning and memory in a subject, the method comprising the step of administering postnatally to the subject in an amount sufficient to improve postnatal learning and memory of the subject, a mixture of: (a) an Activity Dependent Neurotrophic Factor (ADNF) I polypeptide comprising an active core site having the following amino acid sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO:1); and (b) an Activity Dependent Neurotrophic Factor (ADNF) III polypeptide comprising an active core site having the following amino acid sequence: Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln (SEQ ID NO:2); and assessing learning and memory of the post-natal subject, wherein the active core site of at least one of the ADNF I polypeptide and the ADNF III polypeptide comprises all D-amino acids.