Patent ID: 6048530
Filing Date: 2000-04-11
Classification: A61K,A61P,C07K,C12N,Y02A,Y10S

Abstract:
A method for preparing a composition for eliciting in a mammal an immune response against an intracellular pathogen selected from the group consisting of a bacterium, protozoan, fungus and parasite, the method comprising(a) isolating from an eukaryotic cell infected with said pathogen a population of immunogenic mammalian stress protein-peptide complexes, said population comprising a complex of a mammalian stress protein noncovalently associated with a peptide that is present in an eukaryotic cell infected with said pathogen but not present in said cell when said cell is not infected with said pathogen, and(b) combining an amount of said complexes which is sufficient to elicit an immune response with a pharmaceutically acceptable carrier.