Patent ID: 7378090
Filing Date: 2008-05-27
Classification: A61K,C07K,G01N

Abstract:
1. A method of identifying a substance that affects a short term memory problem or a short term memory formation component of a psychiatric dysfunction associated with atypical PKM zeta (aPKMζ) protein in a mammal, comprising: (a) administering said substance to a mammalian animal model; and (b) determining whether said substance alters the expression or activity of an aPKMζ protein in the central nervous system of said mammalian animal model when compared to the expression or activity of said aPKMζ protein in the absence of said substance; wherein a change in the expression or activity of said aPKMζ in the presence of said substance, compared to the expression or activity of said aPKMζ in the absence of said substance, is indicative that said substance affects short term memory formation or said short term memory formation component of said psychiatric dysfunction.