Patent ID: 9181342
Filing Date: 2015-11-10
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody selected from the group consisting of: a) a monoclonal antibody that specifically binds to PD-1 produced by the hybridoma clone 19 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090901; b) an isolated antibody or antigen binding fragment that binds to PD-1 and comprising: i) a light chain comprising SEQ ID NO: 27 (light chain CDR1), SEQ ID NO: 28 (light chain CDR2), SEQ ID NO:29 (light chain CDR3) and a heavy chain comprising SEQ ID NO:30 (heavy chain CDR1), SEQ ID NO:31 (heavy chain CDR2) and SEQ ID NO:32 (heavy chain CDR3); or ii) a light chain comprising SEQ ID NO:27 (light chain CDR1), SEQ ID NO:28 (light chain CDR2), SEQ ID NO:29 (light chain CDR3) and a heavy chain comprising amino acids 6-10 of SEQ ID NO:30 (heavy chain CDR1; Kabat numbering system), SEQ ID NO:31 (heavy chain CDR2) and SEQ ID NO:32 (heavy chain CDR3); and c) an isolated antibody or antigen binding fragment that binds to PD-1, said isolated antibody or antigen binding fragment comprising SEQ ID NO:12 and SEQ ID NO:14.