Patent ID: 8460641
Filing Date: 2013-06-11
Classification: A61K,A61P,A61Q

Abstract:
1. An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the composition comprising: at least one pharmaceutically active ingredient which is insoluble or only sparingly soluble in water; an oil in water microemulsion or sub-micron emulsion comprising an oil phase dispersed throughout a water phase, said oil phase comprising at least one occlusive agent selected from the group consisting of mineral oil, petrolatum, and mixtures thereof, and at least one lipophilic surfactant; and said water phase comprising at least one hydrophilic surfactant and water; a propellant; and a non-surfactant amphiphilic compound that is a water miscible organic solvent selected from the croup consisting of a glycol, a polyol, and mixtures thereof, wherein the non-surfactant amphiphilic compound is added to the composition after formation of the microemulsion or sub-micron emulsion and is miscible in said water phase, wherein the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant is approximately 9.0:1.0 to 2.0:3.0, and wherein the composition is dispensed as an aerosol foam or mousse and wherein said pharmaceutically active agent is in said water phase or wherein said pharmaceutically active agent is in both said oil phase and said water phase.