Patent ID: 7205385
Filing Date: 2007-04-17
Classification: A61K,C07D

Abstract:
1. A method for preparing a polypeptide comprising monomer units (I), (II), and (III): wherein said monomer units (I), (II), and (III) are randomly distributed or occurring together in said polypeptide; wherein (A) is a first amino acid selected from the group consisting of rysine and ornithine, and (B) is a second amino acid which is the same as or different from (A); and (C) is a third amino acid different from both (A) and (B); wherein (X) is an imaging agent conjugated to said first amino acid (A), wherein said imaging agent (X) is selected from the group consisting of organic nitroxyl radicals, iodinated organic species, chelator moieties, and protected chelator moieties; wherein said imaging agent (X) is optionally complexed with a paramagnetic cation or a radioactive cation when said selected imaging agent is a chelator moiety; wherein said imaging agent (X) is optionally conjugated to said first amino acid (A) through a linking group selected from the group consisting of C wherein m is the mole fraction of said monomer units (II) having a numeral value ranging from 0 to about 0.99; and n is the mole fraction of said monomer units (III) having a numeral value ranging from 0 to about 0.99, wherein n>0 only when m>0, wherein the sum of m+n≦0.99; and wherein 1−(m+n) is the more fraction of said monomer units (I); said method comprising the steps of