Patent ID: 6388086
Filing Date: 2002-05-14
Classification: C07D

Abstract:
A process for producing a 3-(3-pyridyl)-1-propanol derivative (3): in the formula, R1 represents an alkyl group of 1 to 20 carbon atoms, aryl group of 6 to 20 carbon atoms or aralkyl group of 7-to-20 carbon atoms, which may be substituted,which comprises reacting a 3-methylpyridine with a strong base to prepare a 3-methylpyridine metal salt (1): in the formula, M represents lithium, sodium, potassium or a magnesium halide, where the halide is chloride or bromide,and then reacting said metal salt with an epoxy compound (2): in the formula, R1 is as defined above,to give a 3-(3-pyridyl)-1-propanol derivative, wherein the 3-methylpyridine is used in molar in excess of said strong base.