Patent ID: 8481579
Filing Date: 2013-07-09
Classification: A61P,C07D

Abstract:
1. A method for treating a CCR2-mediated condition or disease or a CCR9-mediated condition or disease selected from the group consisting of: atherosclerosis, restenosis, multiple sclerosis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, renal fibrosis, rheumatoid arthritis, obesity, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, idiopathic pneumonia syndrome, pulmonary fibrosis, transplantation rejection, graft-versus-host disease, and neuropathic pain, comprising: administering to a subject an effective amount of a compound of formula (I), or a salt thereof: where Ar is selected from the group consisting of: substituted or unsubstituted C Y R R R R R R where R 1 and R 2 may, together with the atoms to which they are attached, form a substituted or unsubstituted 5-, 6-, or 7-membered ring.