Patent ID: 6987204
Filing Date: 2006-01-17
Classification: C07C

Abstract:
1. A process for preparing sevoflurane, comprising: (a) treating hexafluoroisopropanol with a reactant selected from paraformaldehyde and 1,3,5-trioxane in the presence of a chlorinating agent to provide chiorosevo and a HFIP hydrolyzable precursor; and treating chiorosevo with a fluoride reagent to give sevoflurane (b) separating the HFIP hydrolyzable precursor from the reaction of (a); (c) heating the separated HFIP hydrolyzable precursor with a strong protic acid at a temperature effective to convert the HFIP hydrolyzable precursor to HFIP; and (d) isolating the recovered HFIP.