Patent ID: 8778379
Filing Date: 2014-07-15
Classification: A61L

Abstract:
1. A method of coating a medical device, comprising: applying a coating composition on an expandable balloon surface of the medical device to form a first layer on the medical device, and applying the coating composition on a stent surface of the medical device to form a second layer on the medical device, the coating composition comprising at least one biological agent and heparin dissolved in a mixture of a first solvent and a second solvent, the first solvent and the second solvent having different evaporation temperatures; evaporating at least a part of one of the first solvent and the second solvent present in the coating composition to create a plurality of expandable pores in the first layer and the second layer; depositing at least one drug in the plurality of expandable pores, wherein the drug is released in relation to a degree of expansion of the first layer and the second layer possessing the plurality of expandable pores; and wherein when the medical device is positioned and expanded at a target site, the plurality of expandable pores of the first layer coated on the expandable balloon surface provide a burst release of the at least one drug, and the plurality of expandable pores of the second layer coated on the stent surface provide a delayed release of the at least one drug.