Patent ID: 6797730
Filing Date: 2004-09-28
Classification: A61P,C07C,C07D

Abstract:
A compound according to Formula (1): wherein:R is selected from the group consisting of C1-6 alkyl, â€”CH2Ar, and Ar; R1 is selected from the group consisting of C1-6 alkyl, â€”C1-4 alkyl-Arâ€², and Arâ€²; R2 is selected from the group consisting of hydrogen, and C1-6 alkyl; Ar is selected from the group consisting of phenyl, furyl, and thienyl, all of which are optionally substituted by one or more Z1 groups; Arâ€² is selected from the group consisting of phenyl, naphthyl, furyl, pyridyl, thienyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, benzofuranyl, indolyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, pyrrolyl, and pyrimidyl; all of which are optionally substituted by one or more Z2 groups; Z1 is independently is selected from the group consisting of C1-3 alkyl, CN, F, Cl, Br, and I; Z2 is independently is selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, â€”(CH2) nC(O)OR2, â€”C(O)NRR2, â€”CN, â€”(CH2)nOH, â€”NO2, F, Cl, Br, I, â€”NRR2, and â€”NHC(O)R2; n is 0 to 4; or a salt, solvate, or physiologically functional derivative thereof.