Patent ID: 8859754
Filing Date: 2014-10-14
Classification: C07B,C07H,C12N

Abstract:
1. A modified ribo-oligonucleotide having the formula comprising: wherein D is deuterium; B is a nucleobase; n is a number greater than 1 and represents the number of nucleosides in the oligonucleotide; W is oxygen or sulfur; Y is oxygen, C1-C18 alkoxy, C1-18 alkyl; NHR3 with R3 being C1-C18 alkyl or C1-C4 alkoxy- C1-C6- alkyl; NR3R4 in which R3 is as defined above and R4 is C1-C18 alkyl, or in which R3 is as defined above and R4 is C1-C18 -alkyl, or in which R3 and R4 form together with the nitrogen atom carrying them, a 5-6 membered heterocyclic ring which can additionally contain another hetero atom from the series O, S and N.