Patent ID: 7737280
Filing Date: 2010-06-15
Classification: A61P,C07D

Abstract:
1. A process for preparing N-[(S)-1-Azabicyclo(2,2,2)oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalene carboxamide (the free base of Cp 9563) of the following formula comprising reacting a (5,6,7,8)-tetrahydro- 1-naphthylenecarboxide (Cp 9588) having the formula, a salt of (S)-3-aminoquinuclidine (Cp 9771) having the formula: and an inorganic base in a solvent mixture comprising water and a water-immiscible organic solvent to obtain said N-[(S)-1-Azabicyclo(2,2,2)oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalene carboxamide;  wherein X is a leaving group selected from the group consisting of: halogen, OCOR, OCOOR, and OSO