Patent ID: 6342247
Filing Date: 2002-01-29
Classification: A61K

Abstract:
A pharmaceutical composition, wherein said composition comprises, based on weight: (a) from about 20 to about 70% irbesartan or a pharmaceutically acceptable salt thereof, (b) from about 1 to about 70% diluent, (c) from about 2 to about 20% binder, (d) from about 1 to about 10% disintegrant, (e) from about 0.1 to about 5% antiadherent, (f) from about 0.2 to about 5% lubricant, (g) from about 0.2 to about 6% surfactant, and optionally (h) up to about 2% coloring agent wherein said diluent is lactose hydrous and microcrystalline cellulose; said binder is pregelatinized starch or povidone; said disintegrant is croscarmellose sodium; said antiadherent is silicon dioxide; said lubricant is magnesium stearate; and said surfactant is poloxamer 188; and wherein a tablet formed from said composition has a dissolution performance such that about 80% or greater of the irbesartan or salt thereof contained in said tablet dissolves within 30 minutes.