Patent ID: 7501538
Filing Date: 2009-03-10
Classification: A61P,C07C,C07D

Abstract:
1. The compound of Formula (I): wherein c is equal to 0; G is: —CO 2 R 1 ; wherein V is: —CH 2 —; X is —N(R 8 )CO—, wherein Ar 1 is a mono-substituted phenyl group, wherein the substituent is selected from the group consisting of: -aryl, -arylene-alkyl, -D-aryl, -D-alkylene-arylene-alkyl, -arylene-D-alkyl, -arylene-D-R 10, and -D-alkylene-arylene-aryl, wherein Ar 2 is a substituted phenyl having 2 to 5 substituents wherein the phenyl is substituted at an ortho and a meta position on Ar 2 , relative to X; and wherein the substituents are independently selected from the group consisting of: -fluoro, -chloro, -bromo, iodo, -cyano, -nitro, - perfluoroalkyl, -T 1 -R 14 , -alkyl, -aryl, -arylene-alkyl, -T 1 -alkyl, -T 1 -alkylene-aryl, -T 1 -alkylene-arylene-aryl, -T 1 -alkylene-arylene-alkyl, -arylene-T 1 -alkyl, -T 1 -arylene-aryl, -T 1 -arylene-alkyl, -T 1 -aryl, -T 1 -alkylene-T 2 -R 14 and -T 1 -arylene-T 2 -R 14 ; wherein and wherein the alkyl, aryl alkylene, and arylene groups in Ar or a pharmaceutically acceptable salt thereof.