Patent ID: 8722919
Filing Date: 2014-05-13
Classification: B01J,C07B,C07C

Abstract:
1. A method for stereoselectively producing a compound represented by the following formula (I): comprising: initiating a reaction of a Schiff base represented by the formula (II): in a medium in the presence of an optically-active phase-transfer catalyst other than a phase-transfer catalyst complexed with an optically-active metal atom and an aqueous inorganic base solution; and quenching the reaction at a time earlier than a time for completion of a stoichiometric reaction of the compound represented by the formula (II) with the compound represented by the formula (III); wherein in the formula (I) and the formula (II), R a C a C an aryl group that may be substituted with a halogen atom, a C a cyano group, —NR a nitro group, a carbamoyl group, an N—(C an N,N-di(C —NHCOR a halogen atom; R wherein in the formula (I) and the formula (III); R (i) a C a C a cyano group, —NR a nitro group, a carbamoyl group, an N—(C an N,N-di(C —NHCOR a halogen atom, —COR —CO (ii) a C (iii) a C (iv) a C (v) an aralkyl group, wherein the aryl moiety of the aralkyl group may be substituted with at least one group selected from the group consisting of: a C a C an aryl group that may be substituted with a halogen atom, a C a cyano group, —NR a nitro group, a carbamoyl group, an N—(C an N,N-di(C —NHCOR a halogen atom; and the alkyl moiety of the aralkyl group is a C (vi) a heteroaralkyl group having a heteroaryl moiety, wherein the heteroaryl moiety may be substituted with at least one group selected from the group consisting of: a C a C an aryl group that may be substituted with a halogen atom, a C a cyano group, —NR a nitro group, a carbamoyl group, an N—(C an N,N-di(C —NHCOR a halogen atom; and the alkyl moiety of the heteroaralkyl group is a C (vii) a C wherein in the formula (III), W is a functional group that has a leaving ability; wherein in the formula (I) and the formula (II), n is an integer from 1 to 4; and wherein in the formula (I), * shows a newly produced asymmetric center.