Patent ID: 6290955
Filing Date: 2001-09-18
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method for prolonged immunosuppression comprising administering, to a subject in need of said immunosuppression, a pharmaceutically effective amount of a first antibody, having binding specificity for all of said subject's T cells and which is capable of depleting substantially all of said T cells in vivo, andthereafter administering a pharmaceutically effective amount of a second antibody having binding specificity for all of said subject's T cells and which is capable of prolonging said depletion of said T cells in vivo, or is capable of modulating the antigen effect of said T cells or is both capable of prolonging said depletion of said T cells in vivo and capable of modulating the antigen effect of said T cells,wherein said first antibody has a heavy chain constant region which is of a different animal species than the heavy chain constant region of said second antibody.