Patent ID: 6582351
Filing Date: 2003-06-24
Classification: A61P,C07D

Abstract:
A compound of the formula (Ia): whereinXa is nitrogen atom; Ya is oxygen atom; R1a is cyano group; nitro group; carbamoyl group; a lower alkylcarbamoyl group which may be substituted with a heterocyclic group; carboxy group; a lower alkoxycarbonyl group; a lower alkyl group; a halo(lower)alkyl group; a lower alkanoyl group; an aroyl group; or a lower alkanesulfonyl group, R2a is a cycloalkyl group which has one to three substituents selected from the group consisting of hydroxy, acyloxy, acyl, lower-alkoxy-substituted aralkyloxy, amino, acylamino, lower alkoxycarbonylamino, lower alkanesulfonylamino, ureido, lower alkylureido, sulfamoylamino, lower alkoxycarbonyl, lower alkanesulfonyl, lower alkyl, hydroxy(lower)alkyl, acyloxy(lower)alkyl, lower alkylenedioxy, carbamoyl, and sulfamoyl; R3a, R4a and R5a are, the same or different, hydrogen atom, a halogen atom, a lower alkanoyl group, carboxy group, a protected carboxy group, carbamoyl group, nitro group, cyano group, a lower alkyl group optionally substituted by hydroxy, a lower alkoxy group or a lower-alkoxy-substituted aralkyl group; or two of R3a, R4a and R5a may combine together to form a lower alkylenedioxy group, and m is an integer of 1 or 2, its prodrug or a pharmaceutically acceptable salt thereof.