Patent ID: 6713496
Filing Date: 2004-03-30
Classification: C07D

Abstract:
A compound according to formula (I) wherein:n is 0, 1, 2 or 3; R1 is selected from a. an optionally substituted straight chain or branched chain C1-6 alkyl group, b. an optionally substituted straight chain or branched chain C2-6 alkenyl group, c. an optionally substituted straight chain or branched chain C2-6 alkynyl group, d. Aryl, e. Aromatic heterocycle, f. Heterocycle, and g. hydrogen; where the optional substituents in groups (a), (b) and (c) above are selected from: C3-7 cycloalkyl, Aryl, Aromatic heterocycle, Heterocycle, OR10, NR10R11, S(O)pR10, OC(O)R11, CO2R10, CONR10R11, SO2NR10R11, halo and NHSO2R10, and where p is 0, 1 or 2; R2, R3, R4, R6, R7 and R9 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl optionally substituted by OR10 or halo; R5 and R8 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl optionally substituted by OR10 or halo, or together are a C2-6 alkylene chain; R10 and R11 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl; Aryl is a 6-14 membered aromatic monocyclic or fused polycyclic carbocyclic group optionally substituted with one or more groups selected from R12, halo, OR13, NR13R14, NR13CO2R12, CO2R13, NR13SO2R12, CN, haloalkyl, O(haloalkyl), SR13, S(O)R12, SO2R12, OC(O)R13, SO2NR13R14, C(O)NR13R14, C3-7 cycloakyl, O(C3-7 cycloalkyl), R15 and OR15, where R12 is straight chain or branched chain C1-6 alkyl, R13 and R14 are each independently selected from hydrogen and straight chain or branched chain C1-6 alkyl, and R15 is phenyl optionally substituted by R12, OR13, halo or haloalkyl; Aromatic heterocycle is a 5 to 7 membered aromatic ring containing from 1 to 3 heteroatoms, each independently selected from O, S and N, said ring being optionally substituted with one or more groups selected from OR13, NR13R14, CO2R13, NR13CO2R12, R12, halo, CN, haloalkyl, O(haloalkyl), SR13, S(O)R12, SO2R12, OC(O)R13, NR13SO2R12, SO2NR13R14 and C(O)NR13R14; and Heterocycle is a 3 to 8 membered ring containing from 1 to 3 heteroatoms, each independently selected from O, S and N, said ring being saturated or partially saturated, said ring further being optionally substituted with one or more groups selected from OR13, NR13R14, CO2R13, NR13CO2R14, R12, halo, CN, haloalkyl, O(haloalkyl), SR13, S(O)R12, SO2R12, OC(O)R13, NR13SO2R12, SO2NR13R14 and C(O)NR13R14, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.