Patent ID: 6472398
Filing Date: 2002-10-29
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound having structural formula Ia: whereinn is 0, 1, or 2; X is N-SO2R8; R6 is hydrogen, halo, or methoxy; R2 is hydrogen or methyl; R9 is hydrogen or halo; R4a and R4b are each independently selected from the group consisting of hydrogen, amidino, C1-4 alkyl, (CH2)0-1 aryl, (CH2)0-1C3-6 cycloalkyl, CO2R7, CO(CH2)0-1C(Me)2NH2, COC(Me)2NHCO2R7, (CH2)2OR7, COR7, CONR7R7, SO2R7, and SO2NR7R7; in which aryl is unsubstituted or substituted with one to three groups independently selected from R6; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; each R7 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; and R8 is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; wherein aryl is unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, and (CH2)n are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; or a pharmaceutically acceptable salt thereof.