Patent ID: 6399079
Filing Date: 2002-06-04
Classification: A61J,A61K,A61P

Abstract:
A pharmaceutical formulation for oral administration from a squeezable container, comprising a pharmaceutical agent in a vehicle comprising a liquid base and a thickening agent, the formulation consisting of mutually compatible components, wherein said thickening agent comprises components selected from the group consisting of cellulose derivatives in an amount of less than about 2 weight % by volume, and water-soluble carboxyvinyl polymer in an amount less than 1 weight % by volume, the formulation having the following properties:an initial viscosity within the range of about 5,000 cps to about 12,500 cps; a viscometric yield value of a semi-solid; a spill resistant consistency permitting the formulation to be squeezed by light manual pressure through a channel of about 1 to about 5 mm, to spread in a spoon bowl sufficiently quickly for accurate measurement, and to remain in the spoon bowl without spilling for at least about one second and less than about 20 seconds on spoon tilting, and for at least about 30 seconds upon spoon vibration; homogeneity wherein the components do not separate under conditions of use; and storage stability.