Patent ID: 6573288
Filing Date: 2003-06-03
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula (I) or a physiologically tolerable salt of formula (I), wherein formula (I) is in which the symbols have the following meanings:X is equal to R(1) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; or â€”CaH2a-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(19)R(20); R(19) and R(20) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; a is zero, 1 or 2; or R(1) is â€”CbH2b-heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(21)R(22); R(21) and R(22) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; b is zero, 1 or 2; or R(1) is â€”CcH2c-cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms; c is zero, 1 or 2; R(2) and R(3) independently of one another are hydrogen, F, Cl, Br, I, CF3, â€”CN, â€”NO2, CH2OR(23), COâ€”R(24) or Oâ€”R(25); R(23) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(24) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, OR(26) or phenyl; where phenyl is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(27)R(28); R(27) and R(28) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; R(26) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(25) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or phenyl; where phenyl is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(29)R(30); R(29) and R(30) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; or R(25) is heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(31)R(32); R(31) and R(32) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; or R(2) and R(3) independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms; or â€ƒâ€”CdH2d-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(33)R(34); R(33) and R(34) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; d is zero, 1 or 2; or R(2) and R(3) independently of one another are â€ƒâ€”CeH2e-heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(35)R(36); R(35) and R(36) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; e is zero, 1 or 2; or R(2) and R(3) independently of one another are â€ƒâ€”SOfâ€”R(37); R(37) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, or â€ƒâ€”CgH2g-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(38)R(39); R(38) and R(39) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; f is zero, 1 or 2; g is zero, 1 or 2; R(4) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, 1-naphthyl, 2-naphthyl, â€”CiH2i-cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or â€”CiH2i-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, SOjR(48), OR(49), NR(50)R(51), â€”CN, â€”NO2 or COâ€”R(52); i is zero, 1 or 2; R(48) is alkyl having 1, 2, 3 or 4 carbon atoms or NR(53)R(54); R(53) and R(54) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; j is zero, 1 or 2; R(49) is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(50) and R(51) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(52) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or OR(55); R(55) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7, or 8 carbon atoms; or R(4) and R(6) together with the carbon atom carrying them are cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or fluorenyl; R(5), R(6), R(7) and R(8) independently of one another are hydrogen, F, CF3, Oâ€”R(56), alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, â€”CkH2k-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(57)R(58); R(57) and R(58) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; k is zero, 1 or 2; R(56) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(59)R(60); R(59) and R(60) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, R(56) is heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(61)R(62); R(61) and R(62) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; or R(5) and R(7) together are a second bond between the carbon atoms carrying the radicals R(6) and R(8), where R(4), R(6) and R(8) are as defined above; R(9) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or â€”CIH2I-IIâ€”A; II is zero or 2; and I is zero, 1, 2, 3 or 4; where I is unequal to zero or 1, when II is equal to 2; R(10) is hydrogen; alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms; or â€”CmH2m-mmâ€”B, mm is zero or 2; and m is zero, 1,2,3 or 4; where m is unequal to zero or 1, when mm is equal to 2; R(11) and R(12) independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; Z is carbonyl or sulfonyl; A and B independently of one another are 1. aryl having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms; 2. a radical as defined in 1, substituted by 1, 2 or 3 identical or different radicals from alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, SOnR(63), OR(64), NR(65)R(66), â€”CN, â€”NO2 or COâ€”R(67); 3. heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms; 4. a radical as defined in 3, substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(68)R(69); 5. cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms; 6. Oâ€”R(70); or 7. Oâ€”R(71); n is zero, 1 or 2; R(70) and R(71) independently of one another are 1. hydrogen; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 3. â€”CoH2o-oo-phenyl, oo is zero or 2; and o is zero, 1, 2, 3 or 4; where o is unequal to zero or 1, when oo is equal to 2; 4. a radical as defined in 3, where the phenyl moiety is substituted by 1, 2 or 3 identical or different radicals from alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, SOpR(72), OR(73), NR(74)R(75), â€”CN, â€”NO2 or COâ€”R(76); or 5. alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(63) and R(72) independently of one another are alkyl having 1, 2, 3 or 4 carbon atoms or NR(77)R(78); R(67) and R(76) independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or OR(89); R(89) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(64), R(65), R(66), R(68), R(69), R(73), R(74), R(75), R(77) and R(78) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; p is zero, 1 or 2; R(13), R(14) and R(15) independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, â€”CN, â€”NO2, SOqâ€”R(79), COâ€”R(80) or Oâ€”R(81); q is zero, 1, or 2; R(79) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(82)R(83); R(82), R(83) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(80) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or OR(84); R(84) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(81) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(82)R(83); Y is CR(16)R(17), CO, S, SO2, O, or NR(18), R(16) is hydrogen or â€”OR(85); R(85) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or COâ€”R(86); R(86) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy or hydroxyl; R(17) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(18) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, COâ€”R(87) or SO2R(88); R(87) and R(88) independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from F, Cl, Br, I, CF3, methyl, methoxy or hydroxyl.