Patent ID: 8110223
Filing Date: 2012-02-07
Classification: A61K,A61P

Abstract:
1. A compressible dosage form comprising a substantially uniform distribution of active cushioning components, wherein the active cushioning component is a bead, granule, particle or pellet and, wherein the active cushioning component comprises: a) a core comprising an active-loaded particle; and b) a porous cushioning layer surrounding the core, wherein the cushioning layer comprises a highly compactable filler, and a highly water absorbing material; wherein the active cushioning component is made by a process comprising i) admixing the highly compactable filler, the highly water absorbing material, water and the active-loaded particles to form an admixture and forming a bead, granule, particle or pellet; and ii) freeze-drying the bead, granule, particle or pellet to form the active cushioning component, wherein the freeze-drying process creates the porous cushioning layer that surrounds the active-loaded particle core, wherein the active-loaded particles exhibit substantially no fracturing or degradation during compression.