Patent ID: 6638981
Filing Date: 2003-10-28
Classification: A61K,A61P,Y10S

Abstract:
A emulsion comprising:(a) amitriptyline or a pharmaceutically acceptable salt thereof; (b) ketamine or a pharmaceutically acceptable salt thereof; (c) a lipophilic component; (d) water; and (e) a surfactant, wherein the emulsion is an oil in water emulsion and further comprises a lipophilic intradermal penetration enhancer selected from the group consisting of isopropyl myristate, glycerol monolaurate, glycerol monooleate, glycerol monolinoleate, isopropyl isostearate, isopropyl linoleate, isopropyl myristate/fatty acid monoglyceride combination, isopropyl myristate/ethanol/l-lactic acid combination, isopropyl palmitate, methyl acetate, methyl caprate, and methyl laurate.