Patent ID: 6380256
Filing Date: 2002-04-30
Classification: C07C

Abstract:
A compound of the formula wherein A is a phenyl or naphthyl group, said phenyl and naphthyl groups being optionally substituted with one or two R2 groups;R is H, alkyl of 1 to 6 carbons or benzyl; Y is H, alkyl of 1 to 10 carbons, benzyl, lower alkyl or halogen substituted benzyl, fluoro-substituted alkyl of 1 to 10 carbons, cycloalkyl of 3 to 6 carbons, lower alkyl substituted cycloalkyl of 3 to 6 carbons, Cl, Br, or I; R1 is independently H or alkyl of 1 to 6 carbons; R2 is independently H, alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; R3 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, alkylthio of 1 to 6 carbons or benzyl; m is an integer having the values 0 to 2; R4 is independently H, alkyl of 1 to 6 carbons, or F; fluorosubstituted alkyl of 1 to 6 carbons, or halogen; o is an integer having the values of 0 to 4; R6 is cycloalkyl of 3 to 6 carbons, lower alkyl substituted cycloalkyl of 3 to 6 carbons or branch-chained alkyl of 3 to 6 carbons; n is an integer having the values of 0 to 4, and R8 is H, alkyl of 1 to 6 carbons, â€”CH2O(C1-6-alkyl), or a cation of a pharmaceutically acceptable base.