Patent ID: 7462350
Filing Date: 2008-12-09
Classification: A61P,C07K

Abstract:
1. A method of inhibiting solid tumor growth in a cancer patient comprising the step of: administering to the cancer patient a fusion protein comprising a non-IL-2 moiety fused to a mutant IL-2 moiety, wherein the mutant IL-2 moiety comprises an amino acid substitution changing an aspartic acid to a threonine at a position corresponding to position 20 of a mature human IL-2 protein wherein the mature human IL-2 protein consists of the amino acid sequence set forth in SEQ ID NO:3, and wherein said fusion protein exhibits greater selectivity than a reference protein towards cells expressing a high affinity receptor, wherein said reference protein comprises the non-IL-2 moiety fused to a non-mutant IL-2 moiety, and wherein said selectivity is measured as a ratio of activation of cells expressing IL-2Rαβγ receptor relative to activation of cells expressing IL-2Rβγ receptor.