Patent ID: 9018173
Filing Date: 2015-04-28
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A compound that uncouples collapsin response mediator protein 2 (“CRMP-2”) and N-type voltage-gated calcium channels (“CaV2.2”), comprising: a compound of the formula X-Z, wherein X is a polypeptide having at least 80 percent identity to at least one polypeptide selected from the group consisting of: SEQ ID NO.: 12 and SEQ ID NO.: 13; Z is at least one polypeptide having at least 80 percent identity to at least one polypeptide selected from the group consisting of: SEQ ID NO.: 1, SEQ ID NO.: 3, SEQ ID NO.: 4, SEQ ID NO.: 5, SEQ ID NO.: 6, SEQ ID NO.: 7, SEQ ID NO.: 8, SEQ ID NO.: 9, and SEQ ID NO.: 10, wherein X and Z are fused to one another; wherein X retains the function of transducing Z into cells, and wherein Z binds to the CaV2.2 via its first intracellular loop (“L1”) and/or the end of the C-terminus (“Ct-dis”) regions.