Patent ID: 6630461
Filing Date: 2003-10-07
Classification: C07D

Abstract:
A method of treating a disease selected from the group consisting of Alzheimer's Disease, Huntington's chorea, Parkinson's Disease and Creutzfeld Jacob Disease in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and R1 and R2 are individually selected from the group consisting of hydrogen, halogen, â€”OH, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms, R3 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and â€”COR4, R4 is alkyl of 1 to 6 carbon atoms, B is selected from the group consisting of alkyl of 1 to 6 carbon atoms and carbocyclic aryl and heterocyclic aryl of 5 to 6 ring members containing in the ring 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur with the aryl unsubstituted or substituted with at least one member of the group consisting of alkyl, alkenyl and alkoxy of up to 6 carbon atoms, X is selected from the group consisting of a single bond, â€”Z1â€”, â€”Z1COâ€”, â€”CH&boxH;, â€”CH&boxH;CHâ€”COâ€”, â€”Z1â€”NR3â€”COâ€”Zâ€²1â€”, â€”CONR3â€”Zâ€²1â€”, â€”Z1â€”NR3â€”CSâ€” and â€”Z1â€”NR3â€”SO3â€”, Het is a heterocycle selected from the group consisting of oxetane, pyrrole, pyrrolidine, furan, tetrahydrofuran, thiophene, tetrahydrothiophene, sulpholane, imidazole, imidazoline, dihydroimidazole-2-one, dihydroimidazole-2-thione, oxazole, isoxazole, oxazoline, isoxazoline, oxazolidine, oxazolidinone, thiazole, thiazoline, thiazolidine, thiazolidinone, hydantoine, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,1-dioxyde-1,2,5-thiadiazolidine, 1,2,4-triazole-3-one, tetrazole, tetrahydropyridine, piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethyl-piperazine and 4-aminopiperidine, Y is selected from the group consisting of Z2â€”Qâ€”, â€”Z2COâ€”, â€”Z2â€”NHâ€”COâ€”, â€”Z2â€”CH2â€”NR3â€”COâ€”, â€”NR3â€”Z2â€”Qâ€”, â€”NR3â€”COâ€”Z2â€”Qâ€”, â€”NR3â€”NHâ€”COâ€”Z2â€”, â€”NHâ€”NHâ€”Z2â€”, â€”NR3â€”Oâ€”Z2â€”, â€”NR3â€”SO2â€”NR3â€”Z2â€”, â€”Oâ€”Z2â€”Qâ€”, â€”Oâ€”COâ€”Z2â€”Qâ€” and â€”Sâ€”Z2â€”Qâ€”, Q is selected from the group consisting of â€”Oâ€”Z3, â€”R3â€”Nâ€”Z3 and â€”Sâ€”Z3, Z1, Zâ€²1, Z2 and Z3 are individually selected from the group consisting of a single bond and alkylene of 1 to 6 carbon atoms, R6 is hydrogen or â€”OH and its non-toxic, pharmaceutically acceptable salts sufficient to treat said disease.