Patent ID: 9051437
Filing Date: 2015-06-09
Classification: A61K,C08G,C08L,Y10T

Abstract:
1. A vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked by adding a crosslinking agent in an amount of 0.05 to 20 equivalents per equivalent of a carboxyl group in the anionic segment of the second polymer or 0.05 to 20 equivalents per equivalent of an amino group in the cationic segment of the first polymer, or in an amount of 0.05 to 20 equivalents of a thiol group in the cationic segment of the first polymer of the anionic segment of the second polymer, wherein the first polymer is: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment; or (b) an amino acid polymer (I) having a cationic segment, and the second polymer is: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment; or (d) an amino acid polymer (II) having an anionic segment, wherein a crosslinked site has a structure comprising disulfide bonds, wherein the cationic segment is represented by the following formula (1): wherein: R R R m and n are 1 or 2; a1 and a2 are an integer from 0 to 5,000, b1 and b2 are an integer from 0 to 5,000, and a1+a2+b1+b2 is 2 to 5,000; and “/” means that the sequence order of monomer units is arbitrary, and wherein the anionic segment is represented by the following formula (2): wherein: R R R R R c1 and c2 are an integer from 0 to 5,000, d1 and d2 are an integer from 0 to 5,000, and c1+c2+d1+d2 is 2 to 5,000; and “/” means that the sequence order of monomer units is arbitrary.