Patent ID: 6103905
Filing Date: 2000-08-15
Classification: C07D

Abstract:
The compound represented by the following general structure: ##STR634## wherein Q represents a hydrophobic group at any one of positions 4, 5, 6, or 7 of the B-ring of the indole moiety, or is absent;X represents heterocyclyl, amidinyl, formamidonyl, guanidinyl, --CN, --C(S)NR.sub.2, --N(R)C(S)R, --OR, --SR, --NR.sub.2, or --PR.sub.2 ;Z represents --C.tbd.C--, --(E)--CH.dbd.CH--, --(Z)--CH.dbd.CH--, or --CH.sub.2 CH.sub.2 --, and is bonded to any one of positions 5, 6, 7, or 8 of the B-ring of the quinoline moiety;L represents a hydrophobic group at any one of positions 5, 6, 7, or 8 of the B-ring of the quinoline moiety that is not bonded to Z, or is absent;R represents, independently for each occurrence, H, lower alkyl, lower heteroalkyl, aryl, heteroaryl, acyl, sulfonyl, or --(CH.sub.2).sub.m R.sub.8 ;the two instances of R taken together in an instance of --NR.sub.2 may form a ring comprising that nitrogen;R.sub.1 ' represents H, alkyl, aryl, p-toluenesulfonyl, --(CH.sub.2).sub.d N(Phth), or --(CH.sub.2).sub.d N(R).sub.2 wherein d is an integer in the range 1 to 6 inclusive;R.sub.2 ' and R.sub.3 independently for each occurrence represent H, lower alkyl, or aryl;R.sub.8 represents, independently for each occurrence, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocyclyl, or polycyclyl;m is, independently for each occurrence, an integer selected from the range 1-8 inclusive; andn is an integer selected from the range 1-4 inclusive.