Patent ID: 6242437
Filing Date: 2001-06-05
Classification: A61P,C07D

Abstract:
A cephem derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof: ##STR14##whereinX represents CH or N;R.sup.1 represents a hydrogen atom,C.sub.1-6 alkyl in which one or more hydrogen atoms in the alkyl is optionally substituted by a halogen atom, a hydroxyl group, carboxyl, C.sub.1-6 alkoxy-carbonyl, carbamoyl, N--C.sub.1-6 alkylcarbamoyl, cyano, amino, or C.sub.1-6 alkylamino,C.sub.2-6 alkenyl,C.sub.2-6 alkynyl, or cycloalkyl;any one of R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represents R.sup.6 R.sup.7 NSO.sub.2 NH--C.sub.1-6 alkyl where R.sup.6 and R.sup.7, which may be the same or different, represent a hydrogen atom or C.sub.1-6 alkyl, andthe other substituents of R.sup.2, R.sup.3, R.sup.4, and R.sup.5, which may be the same or different, each independently represents a hydrogen atom; C.sub.1-6 alkoxy; C.sub.1-6 alkylthio; cyano; carboxyl; C.sub.1-6 alkoxy-carbonyl; carbamoyl; C.sub.1-6 alkyl-carbamoyl; formyl; amino; formylamino; acetylamino; methanesulfonylamino; a halogen atom; C.sub.1-6 alkyl (in which one or more hydrogen atoms in the alkyl is optionally substituted by a hydroxyl group, C.sub.1-6 alkoxy, mercapto, C.sub.1-6 alkylthio, cyano, a halogen atom, carboxyl, C.sub.1-6 alkoxy-carbonyl, carbamoyl, N--C.sub.1-6 alkyl-carbamoyl, formyl, acetyl, acetoxy, hydroxyimino, C.sub.1-6 alkoxyimino, amino, formylamino, acetylamino, trifluoroacetylamino, carbamoyloxy, N--C.sub.1-6 alkyl-carbamoyloxy, methanesulfonylamino, ureido, N--C.sub.1-6 alkylureido, C.sub.1-6 alkoxy-carbonylamino, or iminomethylamino) C.sub.3-6 cycloalkyl; C.sub.2-6 alkenyl; or C.sub.2-6 alkynyl,or any two of R.sup.2, R.sup.3, R.sup.4, and R.sup.5 may combine with each other to represent C.sub.1-6 alkylene, thereby forming a ring, one or more methylene groups in the alkylene being optionally replaced by NH, O, or S, the ring optionally having oxo (.dbd.O) as a substituent; andn is 0 or 1.