Patent ID: 7671087
Filing Date: 2010-03-02
Classification: A61P,C07C,C07D,C40B

Abstract:
1. A method of treating asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, allergy, arthritis, Crohn's disease, malignant gliomas, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, or stroke, comprising the step of: administering to a patient a therapeutically effective amount of a compound of formula A or B, wherein Z represents alkyl, cycloalkyl, alkenyl, aralkyl, heteroaralkyl, hydroxyalkyl, alkoxyalkyl, heterocyclyl, —(CH Ar represents aryl or heteroaryl; X represents aryl, heteroaryl, (aryl)alkenyl, (heteroaryl)alkenyl, or —(CH R R R represents independently for each occurrence alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, halogen, heteroaralkyl, hydroxyl, alkoxyl, amino, alkylamino, carboxylate, carboxamide, nitroso, nitro, sulfhydryl, alkylthio, thioalkyl, silyl, alkylsulfonyl, arylsulfonyl, formyl, acyl, acyloxy, acylamino, alkyloxycarbonyl, alkenyloxycarbonyl, aryloxycarbonyl, or —(CH R′ represents independently for each occurrence H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or —(CH R n is an integer selected independently for each occurrence from the range 0 to 8 inclusive; the absolute stereochemistry at a stereocenter in a compound represented by A is R, S, or a mixture thereof; the absolute stereochemistry at a stereocenter in a compound represented by B is R, S, or a mixture thereof; the configuration of an alkenyl moiety in a compound represented by A is E, Z, or a mixture thereof; and the configuration of an alkenyl moiety in a compound represented by B is E, Z, or a mixture thereof.