Patent ID: 6562627
Filing Date: 2003-05-13
Classification: G01N,Y10T

Abstract:
A method for determining a dissociation constant for each one of at least a portion of a set of compounds, said method comprising:dissolving said set of compounds in an aqueous medium having a predetermined composition, to form a test solution containing the set of compounds; contacting said test solution at a predetermined temperature with a membrane mimetic surface exhibiting a non-specific compound-dependent affinity for at least the portion of the set of compounds; measuring a parameter dependent on the non-specific affinity of the surface for each one of at least the portion of the set of compounds in the test solution after contact of the solution with the surface under the predetermined set of conditions, said parameter measurement including identification of each compound exhibiting said affinity-dependent parameter; and calculating the dissociation constant for each one of at least the portion of the set of compounds using the measured parameter.