Patent ID: 6156732
Filing Date: 2000-12-05
Classification: A61K,C07K,Y10S

Abstract:
A method of treating platelet-mediated thrombotic disorders comprising administering to a patient afflicted with such disorder an effective amount of the compound of the general formula (I) ##STR8## wherein A.sub.1 is an amino acid residue selected from the Sar, Gly, His, His(CH.sub.2 Ph), Ile, Ser, Thr, .beta.-Ala, Ala, a C.sub.2 -C.sub.6 -acyl group and a C.sub.1 -C.sub.8 -alkyl group;wherein A.sub.2 is an alkyl amino acid residue selected from Cha, Leu, Ile, Asp, and Glu or an amino alkyl amino acid residue selected from Lys, His, Orn, homoArg and Arg;wherein A.sub.3 is an amino alkyl amino acid residue selected from Lys, His, Orn, Arg and homoArg;wherein A.sub.4 is an arylalkyl residue selected from Phe and Tyr or an aralkylamino group;wherein R.sub.1 is selected from H or alkyl;wherein R.sub.2 is an aryl, substituted aryl, heteroaryl, substituted heteroraryl aralkyl or substituted aralkyl;wherein R.sub.3 is H or alkyl;wherein X is selected from S, O, or NR.sub.4, wherein R.sub.4 is selected from H or alkyl;and the pharmaceutically acceptable salts thereof to treat such disorder.