Patent ID: 6635770
Filing Date: 2003-10-21
Classification: C07D

Abstract:
A process for producing a hexahydrothieno[3,4-d]imidazole-2,4-dione of formula (1): wherein R1 and R2 are the same or different and independently represent a hydrogen atom, a lower alkyl group, an alkenyl group, an aryl group or an aralkyl group all of which may be substituted, which comprises:reacting a hexahydrofuro[3,4-d]imidazole-2,4-dione of formula (2): â€ƒwherein R1 and R2 are the same as defined above with a thioamide in the presence of an alkali hydrogen sulfide, sulfur and a basic compound selected from an alkali metal carbonate, an alkali metal salt of the carboxylic acid having C2-C6 carbon atoms and an organic base having C6-C10 carbon atoms, wherein the total amount of thioamide, alkali hydrogen sulfide and sulfur is 1.5 moles or less per mol of the compound of formula (2).