Patent ID: 8815855
Filing Date: 2014-08-26
Classification: A61P,C07D

Abstract:
1. A method for treating cancer or benign neoplasia in a patent, in which said cancer is selected from the group consisting of cancer of the breast, bladder, bone, brain, central and peripheral nervous system, colon, endocrine glands, esophagus, endometrium, germ cells, head and neck, kidney, liver, lung, larynx and hypopharynx, mesothelioma, sarcoma, ovary, pancreas, prostate, rectum, renal, small intestine, leukemia, lymphoma, non-Hodgkins disease, chronic and acute myeloid leukaemia acute lymphoblastic leukemia, Hodgkins disease, multiple myeloma and T-cell lymphoma; myelodysplastic syndrome, plasma cell neoplasia, paraneoplastic syndromes, comprising administering to said patient a therapeutically effective and tolerable amount of a compound of formula I in which R1 is hydrogen, R2 is hydrogen, R3 is hydrogen, R4 is hydrogen, R5 is hydrogen, R6 is -T1-Q1, in which T1 is a bond, either Q1 is substituted by R61 and/or R62 on the terminal ring, and is Aa1, Hh1, Ha1, Ha2, Ha3, Ha4 or Ah1, or Q1 is unsubstituted, and is Ha2, Ha3 or Ha4, in which R61 is methyl, methoxy, hydroxyl, trifluoromethyl, hydroxymethyl, methylsulphonylamino, methylcarbonylamino, dimethylaminosulphonyl, -T2-N(R611)R612, —U-T3-N(R613)R614, -T4-Het3, or —V-T5-Het4, in which T2 is a bond, methylene, dimethylene or trimethylene, R611 is hydrogen, methyl, cyclopropyl, cyclopentyl, 2-methoxyethyl, acetyl or methylsulphonyl, R612 is hydrogen or methyl, or R611 and R612 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring Het1, in which Het1 is morpholino, piperidino, pyrrolidino, piperazino or 4-methyl-piperazino, U is —O— (oxygen) or —C(O)NH—, T3 is dimethylene or trimethylene, R613 is hydrogen, methyl, cyclopropyl, cyclopentyl, 2-methoxyethyl, acetyl or methylsulphonyl, R614 is hydrogen or methyl, or R613 and R614 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring Het2, in which Het2 is morpholino, piperidino, pyrrolidino, piperazino or 4-methyl-piperazino, T4 is a bond, methylene, dimethylene or trimethylene, Het3 is 1-methyl-piperidinyl or 1-methyl-pyrrolidinyl, V is —O— (oxygen) or —C(O)NH—, T5 is a bond, methylene, dimethylene or trimethylene, Het4 is 1-methyl-piperidinyl or 1-methyl-pyrrolidinyl, R62 is methyl, Aa1 is 1,1′-biphenyl-3-yl, or 1,1′-biphenyl-4-yl, Hh1 is a bisheteroaryl radical made up of two heteroaryl groups, which are independently selected from the group consisting of pyrrolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, and which are linked together via a single bond, Ah1 is a phenyl-heteroaryl radical made up of an phenyl group and a heteroaryl group selected from the group consisting of pyrrolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, wherein said phenyl and heteroaryl groups are linked together via a single bond, and wherein Ah1 is bonded via said heteroaryl moiety to the parent molecular group, Ha1 is a 3-(heteroaryl)-phenyl or 4-(heteroaryl)-phenyl radical each made up of a heteroaryl group selected from the group consisting of pyrrolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, and a phenyl group, wherein said heteroaryl and phenyl groups are linked together via a single bond, and wherein Ha1 is bonded via said phenyl moiety to the to the parent molecular group, Ha2 is a 3-(heteroaryl)-phenyl or 4-(heteroaryl)-phenyl radical each made up of a heteroaryl group selected from the group consisting of indolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzothiazolyl, indazolyl, benzimidazolyl, benzisoxazolyl, benzisothiazolyl, benzofurazanyl, benzotriazolyl, benzothiadiazolyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, cinnolinyl, indolizinyl and naphthyridinyl, and a phenyl group, wherein said heteroaryl and phenyl groups are linked together via a single bond, and wherein Ha2 is bonded via said phenyl moiety to the to the parent molecular group, Ha3 is a 3-(heteroaryl)-phenyl or 4-(heteroaryl)-phenyl radical each made up of a heteroaryl group selected from the group consisting of thiadiazolyl, oxadiazolyl, triazolyl and tetrazolyl, and a phenyl group, wherein said heteroaryl and phenyl groups are linked together via a single bond, and wherein Ha3 is bonded via said phenyl moiety to the to the parent molecular group, Ha4 is a 3-(heteroaryl)-phenyl or 4-(heteroaryl)-phenyl radical each made up of a heteroaryl group selected from the group consisting of indolinyl, isoindolinyl, 1,2,3,4-tetrahydroquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothiophenyl, benzo[1,3]dioxolyl, 2,3-dihydrobenzo[1,4]dioxinyl, chromanyl, chromenyl and 2,3-dihydrobenzo[1,4]oxazinyl, and a phenyl group, wherein said heteroaryl and phenyl groups are linked together via a single bond, and wherein Ha3 is bonded via said phenyl moiety to the parent molecular group, R7 is hydroxyl, or 2-aminophenyl, or a salt thereof.