Patent ID: 6653326
Filing Date: 2003-11-25
Classification: A61P,C07C,C07D

Abstract:
A method of increasing expression of a molecular chaperon by an eukaryotic cell comprising:treating an eukaryotic cell of a living mammalian organism that is exposed to a physiological stress accompanying allergic diseases, immune diseases, autoimmune diseases, diseases of viral or bacterial origin, tumorous, skin and/or mucous diseases, epithelial disease of renal tubulus, atherosclerosis, coronarial disease, pulmonary hypertonia, cerebrovascular ischemia, stroke, or traumatic head injury with an effective amount of a chemical compound to increase the expression of the molecular chaperon by the cell beyond the amount induced by the physiological stress, wherein the chemical compound is one or more of a hydroxylamine derivative represented by formula (I), â€ƒor a salt thereof or any optically active streoisomer thereof, wherein A is an alkyl, substituted alkyl, aralkyl, aralkyl substituted in one or both of the aryl or alkyl moiety, aryl, substituted aryl, heteroaryl or substituted heteroaryl group, Z is a covalent bond, R is alkyl or substituted alkyl, and X is halo or substituted hydroxy or amino, monosubstituted amino or disubstituted amino group.