Patent ID: 6426402
Filing Date: 2002-07-30
Classification: A61K,A61P,C07K

Abstract:
A compound selected from the group of compounds represented by Formula (I): wherein:R1 and R4 are, independently of each other, hydrogen or alkyl; R2 is: (i) cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocyclo or heterocycloalkyl; provided that R2 does not contain an imidazole group or ii) -(alkylene)-B1â€”X where B1 is â€”Oâ€”, â€”NR8â€”, â€”S(O)0-2, â€”C&boxH;O, â€”CONR8â€”, â€”NR8CO2â€”, NR8SO2â€” or â€”C(&boxH;NR8)NR8SO2-(where R8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or (iii) -(alkylene)-B1â€”X where B1 is â€”NR8COâ€” (where R8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or (iv) R2 and R3 form an alkylene or heteroalkylene chain; with the proviso that R2 does not contain an imidazole group,R3 is hydrogen or alkyl; R6 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R5 is: (i) hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)â€”X1 where X1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NRâ€²Râ€³ (where Râ€² and Râ€³ are independently H or alkyl, or Râ€² and Râ€³ form an alkylene chain); or (ii) R5 and R4 form an alkylene chain; or (iii) R5 and R6 form an alkylene chain; n is 0 or 1; A is â€”N(R10)â€”(CH2)mâ€”CH(R9)â€”C(&boxH;O)â€” wherein: m is an integer from 0-5 inclusive; R9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)â€”X1 where X1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NRâ€²Râ€³ (where Râ€² and Râ€³ are independently H or alkyl, or Râ€² and Râ€³ form an alkylene chain); and R10 is hydrogen, alkyl, aralkyl or heteroaralkyl; Z is Yâ€”B2 wherein: Y is alkylene or a bond; and B2 is â€”COâ€”, â€”OC(O)â€”, with the proviso that when R2 is benzyl, 4-hydroxybenzyl, phenyl, or phenethyl, then Z is not â€”OC(O)â€”; R7 is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or a pharmaceutically acceptable salt, prodrug, or isomer thereof.