Patent ID: 6323203
Filing Date: 2001-11-27
Classification: A61K,Y10S

Abstract:
A method for preventing the onset of symptoms of NIDDM, comprising administering to a patient in need thereof, a compound selected from the group consisting of compounds of formula (I): ##STR5##wherein Y is O;R is NHCONR.sup.4 R.sup.5 ; or N.dbd.C(NR.sup.4 R.sup.5).sub.2 ;R.sup.4 and R.sup.5 are each independently selected from the group consisting of hydrogen; C.sub.1-10 alkyl, straight or branched chain, aryl C.sub.1-4 alkyl; and mono- or disubstituted aryl C.sub.1-4 alkyl where the substitutents are fluoro, chloro, bromo, iodo or C.sub.1-10 alkyl, straight or branched chain;R.sup.1 and R.sup.2 are each independent selected from the group consisting of hydrogen, C.sub.1-10 alkyl, straight or branched chain C.sub.3-8 cycloalkyl, amino and mono- or di-substituted amino where the substitutents are C.sub.1-10 alkyl, straight or branched chain, C.sub.3-8 cycloalkyl; provided that R.sup.1 and R.sup.2 may not both be amino or substituted amino; andR.sup.3 is hydrogen, trifluoromethyl, fluoro, chloro, bromo, or iodo; or a pharmaceutically accepted salt thereof.