Patent ID: 6077855
Filing Date: 2000-06-20
Classification: A61P,C07D

Abstract:
A compound having hemoregulatory activity of the formula ##STR20## wherein: A.sub.1 equals A.sub.2 and denotes a group Z,wherein Z is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinolinyl, tetrahydroquinolinyl, azetidinyl, or pyrrolidinyl wherein the ring is substituted or unsubstituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.4, oxo, oxime, O--C.sub.1-4 alkyloxime, hydroxy, amino, C.sub.1-4 alkylamino, diC.sub.1-4 alkylamino, acylamino or aminoacyl groups;R' and R"" are the same and are hydrogen, or C.sub.1-4 alkyl;Q denotes a group ##STR21## wherein: B.sub.1 equals B.sub.2 and denotes --(CH.sub.2).sub.m+1 --R.sup.2, --(CH.sub.2).sub.m --R.sup.3, or --(CH.sub.2).sub.m --COR.sup.2 ;R.sup.2 denotes --OR.sup.3R.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl; andm is an integer from 0 to 4;C.sub.1 equals C.sub.2 and denotes --(CH.sub.2).sub.n+1 --R.sup.4 or (CH.sub.2).sub.n --R.sup.3 ;R.sup.4 is --OR.sup.3 ;n is an integer from 0 to 4; andD denotes --(CH.sub.2).sub.x --E--(CH.sub.2).sub.y --; whereinE denotes a single bond or --C.dbd.C--, or --C.ident.C--;x and y independently denote an integer from 0 to 5; with the proviso thatx and y are not 0 if E denotes a single bond;and with the proviso that B.sub.1 is not identical to C.sub.1 and B.sub.2 is not identical to C.sub.2, and pharmaceutically acceptable salts thereof.