Patent ID: 6333320
Filing Date: 2001-12-25
Classification: A61P,C07D

Abstract:
A hexahydro-1,4-diazepine compound represented by the following formula (I) or its pharmaceutically acceptable salt: ##STR34##wherein the symbols have the following meanings:A: a phenylene or pyridylene group (which may be substituted),B: forming a 5- or 6-membered aryl or heteroaryl,X: a group of formula, --CO--, --CONH--, --CSNH--, --SO.sub.2 --, --SO.sub.2 NH--, or --SO.sub.2 N(-lower alkyl)-,Y: a bond or a lower alkylene group,R.sup.1 : a hydrogen atom, or a lower alkyl, --L-aryl, --L-heteroaryl, --L--COO-R.sup.6, --L--CON(--R.sup.6)--R.sup.7, --C(.dbd.NH)--NH.sub.2, or --C(.dbd.NH)-lower alkyl group,R.sup.2 : a hydrogen atom, an --O-lower alkyl, --COOH, --COO-lower alkyl, --CONH.sub.2, --CONH-lower alkyl, or --CON--di-lower alkyl group, or an aryl or heteroaryl group (which may be substituted),R.sup.3 an amidino group or a group capable of being converted into an amidino group in a living body,R.sup.4, R.sup.5 : a hydrogen atom or a lower alkyl group, which may be the same or different,R.sup.6, R7: a hydrogen atom or a lower alkyl group, which may be the same or different, andL: a bond or a lower alkylene group.