Patent ID: 6235780
Filing Date: 2001-05-22
Classification: A61K

Abstract:
An .omega.-cycloalkyl-prostaglandin E.sub.1 derivatives of the formula (I) ##STR243##wherein R.sup.1 is hydroxy, C1-6 alkoxy or NR.sup.11 R.sup.12 wherein R.sup.11 and R.sup.12 are independently hydrogen atom or C1-6 alkyl;X is chlorine atom or fluorine atom;R.sup.2 is hydrogen atom, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl, or C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl substituted by 1-3 of the following groups (1).about.(5):(1) halogen atom,(2) C1-4 alkoxy,(3) C3-7 cycloalkyl,(4) phenyl,(5) phenyl substituted by 1-3 substituents selected from halogen, C1-4 alkyl, C1-4 alkoxy, nitro and trifluoromethyl;n is 0-4; and ##STR244##is single-bond, double-bond or triple-bond; or a non-toxic salt thereof or a cyclodextrin clathrate thereof.