Patent ID: 8895694
Filing Date: 2014-11-25
Classification: A61K,A61P,C07K

Abstract:
1. A GLP-1 derivative which comprises a modified GLP-1(7-37) sequence having: i) a total of 3-12 amino acid modifications as compared to GLP-1(7-37) (SEQ ID No: 1), including a) a Aib residue at a position equivalent to position 8 of GLP-1(7-37), b) a Glu residue at a position equivalent to position 22 of GLP-1(7-37), and c) an Arg residue at a position equivalent to position 26 of GLP-1(7-37); and ii) which is derivatised with an albumin binding residue or pegylated in a position selected from a position equivalent to position 18, 20, 23, 30, 31, 34, 36, or 37 of GLP-1(7-37).