Patent ID: 6573284
Filing Date: 2003-06-03
Classification: C07C,C07D

Abstract:
A method of treating melanoma in a patient comprising administering a compound that is capable of releasing a therapeutically active agent (ThrAg) at a desired location, said compound being a substrate for the tyrosinase enzyme and having the formula:TyrXâ€”Bâ€”ThrAg* wherein TyrXâ€” is a residue of an optionally substituted tyrosine analogue of the structure: wherein each Z is independently selected from &boxH;CHâ€”, â€”Câ€”, &boxH;Nâ€”, and &boxH;N+(Oâˆ’)â€”; and R1 and R2 are independently selected from â€”H, â€”Br, â€”Cl, â€”I, â€”F, and â€”OH; wherein B represents a linking group linking TyrXâ€” and ThrAg* selected from: and wherein ThrAg* represents a residue of a therapeutically active agent ThrAg.