Patent ID: 6218413
Filing Date: 2001-04-17
Classification: A61P,C07D

Abstract:
A compound of the formula I ##STR136##or a pharmaceutical acceptable salt thereof wherein:G is ##STR137##R.sub.1 isa) H,b) NH.sub.2,c) NHC.sub.1-4 alkyl,d) C.sub.1-4 alkyl,e) --OC.sub.1-4 alkyl,f) --SC.sub.1-4 alkyl,g) C.sub.1-4 alkyl substituted with one to three fluoro, one to two chloro, CN or --COOC.sub.1-4 alkyl,h) C.sub.3-6 cycloalkkyl,i) N(C.sub.1-4 alkyl).sub.2, orj) N(CH.sub.2).sub.2-5 ;A is ##STR138##R.sub.23 and R.sub.24 are independentlya) H,b) F,c) Cl,d) C.sub.1-2 alkyl,e) CN,f) OH,g) C.sub.1-2 alkoxy,h) nitro, ori) amino;Q is ##STR139##E isa) --S(.dbd.O).sub.i --, orb) --O--;R.sub.38 isa) H,b) C.sub.1-6 alkyl, orc) halo;the dotted line ---- in the ring system of Q is a single or double bond with the proviso that when ---- is a double bond, R.sub.38 is absent;i is 0, 1, or 2;n is 0, 1, 2, 3, 4, or 5; andp is 0, 1, 2, 3, 4, or 5; with the proviso that n and p taken together is 1, 2, 3, 4 or 5.