Patent ID: 8980573
Filing Date: 2015-03-17
Classification: G01N

Abstract:
1. A method for providing a diagnosis of cancer in a subject suspected of having at least one of lung cancer, colon cancer, esophageal cancer, head and neck cancer, stomach cancer, bile duct cancer, pancreatic cancer, kidney cancer, cervical cancer, ovarian cancer, breast cancer, bladder cancer, endometrial cancer and prostate cancer, comprising: contacting, in vitro, a portion of a sample selected from the group consisting of serum and plasma from a subject with a specific binding agent, wherein the specific binding agent is selected from the group consisting of an antibody, a receptor, a lectin and a nucleic acid and has specific binding affinity for a seprase marker, wherein the specific binding agent and the seprase marker form a binding agent seprase marker complex; detecting the binding agent seprase marker complex formed, thereby determining an amount of the seprase marker; comparing the amount of the seprase marker to a control value, wherein the control value is an amount of the seprase marker from a control cohort; and providing a diagnosis of cancer if the amount of the seprase marker is significantly less than the control value based on said step of comparing.