Patent ID: 8486447
Filing Date: 2013-07-16
Classification: A61K,A61P

Abstract:
1. A process for preparing a pharmaceutical product comprising a pharmaceutical active ingredient and a water soluble or partially water soluble polymer comprising the steps of liquefying or softening an amorphous pharmaceutical active ingredient by heating the pharmaceutical active ingredient to a temperature at or above its glass transition temperature; adding the water soluble or partially water soluble polymer to the liquefied or softened pharmaceutical active ingredient at a temperature below the glass transition temperature of the water soluble or partially water soluble polymer to produce a mixture; allowing the mixture to become liquefied throughout; allowing said mixture to form a molecular dispersion of pharmaceutical active ingredient and polymer; and solidifying said dispersion; wherein the amorphous pharmaceutical active ingredient has a solubility in water of less than 200 μg/ml and a glass transition temperature of less than the water soluble or partially water soluble polymer.