Patent ID: 7151112
Filing Date: 2006-12-19
Classification: C07D

Abstract:
1. A method for inhibiting IL-8 or GRO-α driven chemotaxis for treating a disorder selected from the group consisting of psoriasis, atopic dermatitis, arthritis, asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, stroke, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cardiac and renal reperfusion injury, glomerulonephritis, thrombosis, graft vs. host reaction, allograft rejections, malaria, restinosis, and angiogenesis, comprising administering to a patient in need thereof, through a therapeutically acceptable manner, a therapeutically effective amount of a compound of the formula: and prodrugs, solvates and pharmaceutically acceptable salts thereof, wherein R and R and n is 0, 1, 2 or 3; X is selected from oxygen and sulfur; and R