Patent ID: 9056098
Filing Date: 2015-06-16
Classification: A61K,A61N,A61P

Abstract:
1. A method for reducing recurrence of cancerous tumors and minimizing local and distant metastasis comprising administering a composition comprising a hemoglobin-based oxygen carrier at a concentration of 9.5 to 10.5 g/dL in combination with at least one chemotherapeutic agent or radiotherapy to facilitate uptake and localization of the hemoglobin-based oxygen carrier into cancer cells within a mass of cancerous tissues or tumors for inducing apoptosis in cells of said cancerous tissues or tumors including self-renewing and tumor-initiating cells, providing oxidative stress or shock to said cancerous tissues or tumors, and sensitizing the cancerous tissues or tumors to the at least one chemotherapeutic agent or radiotherapy, said composition being either administered to a subject in need thereof concurrently with or subsequently to the at least one chemotherapeutic agent.