Patent ID: 7556827
Filing Date: 2009-07-07
Classification: A61K,A61P

Abstract:
1. An implantable active ingredient depot, wherein the matrix provides a controlled release of the active ingredient, comprising: i) a matrix comprising glyceryl-monooleate and at least one modifier molecule, wherein the modifier molecule is 1,2-distearoyl-glycerophosphatidyl-ethanolamin-methyl-polyethylene glycol (MPEG-DSPE), said matrix forming a cubic phase; and ii) a combination of Carboplatin as an active ingredient in the hydrophilic cubic phase and Taxol as an active ingredient in the hydrophobic lipid bilayer, wherein the release rates of the Carboplatin and Taxol are varied independently by varying the surface area and volume of the matrix and by varying the length of the polyethylene chain of the modifier molecule, respectively.