Patent ID: 6271225
Filing Date: 2001-08-07
Classification: A61P,C07D

Abstract:
A condensed thiophene compound of the formula (IA) ##STR310##whereinX is NH, or N--R.sup.4 wherein R.sup.4 is alkyl;R.sup.1 and R.sup.2 are the same or different and each is hydrogen, alkyl, alkoxy, hydroxyl or halogen;ring A is a benzene ring having 1 to 4 the same or different substituents thereon selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkoxyalkyl, halogen, alkyl halide, nitro, amino, monoalkylamino, dialkylamino, acylamino, hydroxyl and cyano or a benzene ring without a substituent;ring B is a benzene ring wherein the bond shown by a dotted line and a solid line is a double bond; andR.sup.3 is a group of the formula (1), formula (2), formula (3), formula (26), formula (27), formula (28), formula (29) or formula (30) ##STR311##in the formula (1), formula (26), formula (27) and formula (30), R.sup.5, R.sup.6 and R.sup.7 are the same or different and each is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, hydroxyalkyl, hydroxyalkoxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or alkoxyalkyl and a is an integer of 2-4, in the formula (2) and formula (28), R.sup.8 is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, hydroxyalkyl, hydroxyalkoxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acyl, alkoxycarbonyl or alkoxyalkyl, b is 1 or 2,in the formula (3) and formula (29), R.sup.9 is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, hydroxyalkyl, hydroxyalkoxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acyl, alkoxycarbonyl or alkoxyalkyl, or a pharmaceutically acceptable salt thereof or a hydrate thereof.