Patent ID: 9044457
Filing Date: 2015-06-02
Classification: A61K,A61P,C07K

Abstract:
1. An antibody that binds to and is an agonist of DR4, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region and the light chain variable region each comprise the following three complementary determining regions (CDRs): CDR1, CDR2 and CDR3; wherein: i) the CDR1 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:8; ii) the CDR2 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:9; iii) the CDR3 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:10; iv) the CDR1 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:5; v) the CDR2 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:6; vi) the CDR3 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:7.