Patent ID: 7070972
Filing Date: 2006-07-04
Classification: A61K,C07K,C12N

Abstract:
1. Isolated human JAK-3 protein being free of JAK-1 protein said JAK-3 protein being a protein tyrosine kinase that includes an amino acid sequence Gly-Cys-Glu-Thr-His-Ala-Phe-Thr-Ala-His-Pro-Glu-Gly-Lys-His-His-Ser-Leu-Ser-Phe-Ser (SEQ ID NO: 11), said JAK-3 protein having a molecular weight of approximately 125 kDa measurable by SDS polyacrylamide gel electrophoresis in an 8% polyacrylamide gel and Western blotting using an antibody specific for said amino acid sequence, said JAK-3 protein having tandem non-identical catalytic domains, lacking SH2 or SH3 domains, and being expressed in NK cells and stimulated or transformed T cells, but not in resting T cells, said JAK-3 protein being isolatable by immunoprecipitation with said antibody.