Patent ID: 7977383
Filing Date: 2011-07-12
Classification: A01N,A61P

Abstract:
1. A protective solution for avoiding ischemic damage to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryoconservation and subsequent reperfusion, which solution comprises: (a) alkali ions and alkaline earth ions, (b) a buffer comprising N-acetylhistidine as a buffering agent at a concentration in the range of 20 mM to 265 mM, (c) a polyol and/or a saccharide, and (d) one or more compounds selected from the group consisting of: salicylhydroxamic acid, (2-hydroxybenzohydroxamic acid), salicyl-N-methylhydroxamic acid (2-hydroxy-N-methylbenzohydroxamic acid), 3,4-dimethoxybenzohydroxamic acid, 3,4-dimethoxy-N-methyl-benzohydroxamic acid, 2,3-dimethoxybenzohydroxamic acid, 2,3-dimethoxy-N-methyl-benzohydroxamic acid, 3,5-dimethoxy-N-methyl-benzohydroxamic acid, 2,4-dihydroxybenzohydroxamic acid, 2,3-dihydroxybenzohydroxamic acid, 3,4-dihydroxybenzohydroxamic acid, 3,4,5-trimethoxy-benzohydroxamic acid, 3,4,5-trimethoxy-N-methyl-benzohydroxamic acid, 4-hydroxy-3-methoxy-benzohydroxamic acid, 2-hydroxy-3-methoxy-benzohydroxamic acid, and 2-hydroxy-5-methoxy-benzohydroxamic acid; and salts thereof, wherein said solution has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and further wherein the solution comprises N-glycylhistidine in sufficient quantity to act as a buffering agent.