Patent ID: 6787570
Filing Date: 2004-09-07
Classification: C07C,C07D

Abstract:
A compound of Formula G: or a pharmaceutically acceptable salt thereof, wherein;n is 1 or 2; R1 is haloalkyl or haloalkoxymethyl, with the proviso that said haloalkyl has two or more halo substituents; R2 is selected from the group consisting of hydrogen, aryl, alkyl, alkenyl, haloalkyl, haloalkoxy, haloalkoxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, and heteroaryl; R3 is selected from the group consisting of hydrogen, aryl, alkyl, alkenyl, haloalkyl, and haloalkoxyalkyl; Y is oxy or a C1-C2 alkylene; A is a C3-C10 cycloalkyl ring or a C5-C10 cycloalkenyl ring, wherein said cycloalkyl ring or said cycloalkenyl ring is optionally substituted with any one of R10, R11, R12, R31 and R32, at each ring carbon other than the ring carbon attached to the backbone nitrogen atom of Formula G and other than the two ring carbons adjacent to said ring carbon attached to the backbone nitrogen; R4 is hydrogen or halo, unless R4 is bonded together with R5; R5 is hydrogen or R10, unless R5 is bonded together with R4 or R6; R6 is hydrogen or R11, unless R6 is bonded together with R5 or R7; R7 is hydrogen or R12, unless R7 is bonded together with R6 or R8; R8 is hydrogen or halo, unless R8 is bonded together with R7; R10, R11, R12, R31, and R32 are independently selected from the group group consisting of alkyl, halo, haloalkyl, haloalkoxy, aryl, alkylthio, arylamino, arylthio, aroyl, arylsulfonyl, aryloxy, aralkoxy, heteroaryloxy, alkoxy, aralkyl, cycloalkoxy, cycloalkylalkoxy, cycloalkylalkanoyl, heteroaryl, cycloalkyl, haloalkylthio, hydroxyhaloalkyl, heteroaralkoxy, heterocyclyloxy, heterocyclyl, alkylamino, alkenyloxy, aralkylaryl, heteroaryloxyalkyl, heteroarylthio, and heteroarylsulfonyl; R4 and R5 are optionally taken together or R5 and R6 are optionally taken together or R6 and R7 are optionally taken together or R7 and R8 are optionally taken together to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 members, a partially saturated heterocyclyl ring having 5 through 8 members, a heteroaryl ring having 5 or 6 members, and an aryl ring; with the proviso that at least one of R4, R5, R6, R7, or R8 is not hydrogen.