Patent ID: 8058402
Filing Date: 2011-11-15
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody that immunospecifically binds to a human LIGHT (hLIGHT), wherein the antibody comprises: a variable heavy (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of GYNWH (SEQ ID NO:20); a VH CDR2 comprising the amino acid sequence of EITHSGSTNYNPSLKS (SEQ ID NO:21); and a VH CDR3 comprising the amino acid sequence of EIAVAGTGYYGMDV (SEQ ID NO:22); and a variable light (VL) CDR1 comprising the amino acid sequence of RASQGINSAFA (SEQ ID NO:35); a VL CDR2 comprising the amino acid sequence of DASSLES (SEQ ID NO:36); and a VL CDR3 comprising the amino acid sequence of QQFNSYPLT (SEQ ID NO:37).