Patent ID: 7759322
Filing Date: 2010-07-20
Classification: A61K,A61P,C07H,Y10S

Abstract:
1. A method of treating dry eye disease, comprising the step of administering to the eyes of a subject in need thereof an effective amount of a dinucleotide compound as depicted in Formulae II, or a pharmaceutically acceptable salt thereof; and whereby said dinucleotide compound is effective in promoting tear secretion and mucin production in the eyes in a subject in need of such treatment: wherein: X is oxygen, imido, methylene or difluoromethylene; n=0 or 1; m=0 or 1; n+m =0, 1 or 2; and B and B′ are each independently a purine residue, as in Formula IIa, or a pyrimidine residue, as in Formula IIb, linked through the 9- or 1-position, respectively: wherein: R R R R wherein: R R R R or together R R