Patent ID: 6403122
Filing Date: 2002-06-11
Classification: A61K,A61P

Abstract:
An immunomodulatory pharmaceutical composition adopted to form lyotropic liquid crystals in contact with an aqueous phase comprising:A 1 to 35% by weight of an active ingredient selected from: N-methylated cyclic undecapeptides or macrolide lactones; and a carrier medium comprising: B 1 to 40% by weight of at least one absorption promoter; C a non-lipidic vehicle containing at least one of: C1 1 to 80% by weight of a surfactant or mixtures of surfactant with HLB greater than 9; C2 1 to 30% by weight of a lipophilic solvent comprising one or more higher fatly alcohols; and C3 1 to 50% by weight of at least one of the following: a polyether of general formula Hâ€”[Oâ€”CH2â€”CH2â€”]nâ€”OH, where n is an integer from 1 to 20; a cyclic polyether of general formula â€ƒwhere R is C1-3 alkyl; one or more polyols having 3 carbon atoms and/or their mono- to poly-esters with sorbians of fatty acids, macrogolsorbitans of fatty acids, polyoxyethylated fatty acids or mono- to poly-esters of fatty acids; wherein the ratio of components A:B:C is 1:0.1-20:0.5-35 by weight and wherein the aforementioned amounts of ingredients total 100%.