Patent ID: 8927205
Filing Date: 2015-01-06
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
1. A method for extracorporeal depletion or removal of tumor necrosis factor receptor (TNFR) from blood or blood fractions comprising the following steps: a) Optional separation of the blood into one or more blood fractions with solid or liquid components; b) Binding of the blood or the blood fractions expressing a TNFR to a surface or particle coupled to a polypeptide wherein the polypeptide comprises at least three components A and at least two components B, wherein each component A comprises a tumor necrosis factor (TNF) monomer or a functional fragment or a functional variant thereof, and each component B is a peptide linker under conditions allowing binding of TNFR in the blood or the blood fractions to the surface or the particle; and c) Separating the bound TNFR from the blood or the blood fractions, thereby depleting or removing TNFR from the blood or the blood fractions.