Patent ID: 7598384
Filing Date: 2009-10-06
Classification: A61P,C07D

Abstract:
1. A compound selected from those of Formula IA wherein R R R R or one of R R or R R R R and optical isomers, pharmaceutically-acceptable acid and base addition salts, and hydrates thereof; it being understood that: R 2 may not represent unsubstituted phenyl or naphthyl; R 2 may not represent substituted phenyl having at least one ortho-substituent other than hydrogen, relative to the tetrahydroquinoline ring of formula IA to which the phenyl is attached; R 2 may not represent dimethylamino; if one of R 5 and R 6 and one of R 7 and R 8 together represent —(CH 2 ) n — with n being 3, 4 or 5, while the remaining of R 5 and R 6 as well as R 7 and R 8 are both hydrogen, then R 2 may also be halogen; if R 3 and R 4 both represent hydrogen, then R 2 may not represent aryl-heteroaryl, heteroaryl-heteroaryl, arylC 2-6 alkynyl, or heteroarylC 2-6 alkynyl; if R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 all represent hydrogen at the same time, then R 2 may not represent C 2-6 alkyl; if R 3 is cyano, then R 2 may not represent methylthio or ethylthio; R 7 and R 8 may not represent furyl; and the compound of Formula IA may not represent: 2-Benzyloxy-7,8-dihydro-6H-quinoline-5-one, 2-Phenoxy-7,8-dihydro-6H-quinolin-5-one, 2-(1H-Indol-3-yl)-7,8-dihydro-6H-quinolin-5-one, 2-(1H-Indol-3-yl)-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one, 2-Thiophen-2-yl-7,8-dihydro-6H-quinolin-5-one, 2-Ethoxy-7,8-dihydro-6H-quinolin-5-one, 7,7-Dimethyl-2-(6-methyl-pyridin-3-ylmethylsulfanyl)-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile, 2-(1H-Benzoimidazol-2-ylmethylsulfanyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile, 2-(4-Methoxy-phenyl)-7,8-dihydro-6H-quinolin-5-one, 2-(4-Chloro-phenyl)-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one, 2-(4-Fluoro-phenyl)-7,8-dihydro-6H-quinolin-5-one, 2-(4-Isopropyl-phenyl)-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile, or 2-Cyclohexyl-7,8-dihydro-6H-quinolin-5-one.