Patent ID: 8129546
Filing Date: 2012-03-06
Classification: A61P,C07D

Abstract:
1. A method of modulating a sodium ion channel, comprising contacting a cell with a compound having the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ring B is optionally substituted with 1-2 of halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or an optionally substituted aliphatic; each Ra is independently H, an optionally substituted aliphatic, an optionally substituted phenyl, or an optionally substituted benzyl; wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic; each Rb is independently H, an optionally substituted aliphatic, an optionally substituted phenyl or an optionally substituted benzyl, wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic, or Ra and Rb together with the nitrogen atom to which they are bound form a heterocyclic ring, optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic; each Q is a branched or unbranched C each L is absent, —O—, —NRc-, or —S—; each Rc is H, or aliphatic optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic; each Rw is phenyl, indole, or quinoline, wherein the phenyl, indole, or quinoline is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic; each n is 1, 2, or 3; and each m is 1, 2, or 3, provided that the sum of n and m is 3, 4, 5, or 6.