Patent ID: 7655258
Filing Date: 2010-02-02
Classification: A61K

Abstract:
1. A biodegradable polymeric micelle composition, comprising: (a) a copolymer having the formula: wherein C is a core block comprising a bioresorbable hydrophobic polyester segment coupled to a polyol initiator, S is a shell block comprising a hydrophilic polyethylene glycol segment, n is 3, the hydrophobic polyester segment and the hydrophilic polyethylene glycol segment are linked by hexamethylene diisocyanate, and the copolymer is a star copolymer; and (b) an aqueous medium; wherein the copolymer is dispersed in the aqueous medium to form micelles, the bioresorbable hydrophobic polyester segment has an average molecular weight of between 200 and 10,000, and the copolymer dispersed in the aqueous medium has a concentration of 0.001 weight percent, 0.005 weight percent, 0.01 weight percent, 0.025 weight percent, 0.05 weight percent or 0.1 weight percent.