Patent ID: 6713293
Filing Date: 2004-03-30
Classification: A61K,A61P,C07K,C12N

Abstract:
An encapsulated population of cells comprising(a) a eukaryotic cell; (b) an exogenous polynucleotide comprising an expression cassette and an amplification-promoting sequence, said eukaryotic cell comprising said polynucleotide, wherein said expression cassette is stably expressed and comprises a nucleic acid encoding an insulin, an insulin precursor polypeptide, a serotonin, a neurotropic factor, a neurotrophic factor, a tyrosine hydroxylase, a tryptophan hydroxylase, an enkephalin, an enkephalin precursor polypeptide, an enkephalinase, a melanoma inhibitory activity and parathyroid hormone and wherein said amplification-promoting sequence comprises a polynucleotide that is capable of hybridizing under highly stringent conditions to a polynucleotide that is complementary to SEQ ID NO:1 or SEQ ID NO:2; and (c) a capsule, said eukaryotic cell being located in the interior of said capsule.