Patent ID: 6221580
Filing Date: 2001-04-24
Classification: A61K,C07K,Y10S

Abstract:
A method for detecting human anti-HIV-1 antibodies having a common idiotope not found on human non-HIV-1 antibodies comprising the steps of:a) contacting an antibody-containing sample obtained from a subject with an anti-idiotypic monoclonal antibody or binding fragment thereof having specific reactivity with an idiotope specifically bound by monoclonal antibody 1F7 produced by hybridoma ATCC Accession No. HB 11286, and which idiotope is common to at least three types of human anti-HIV-1-antibody of differing specificities, but not significantly reactive with idiotypes of human non-HIV-1 antibodies; andb) determining if the anti-idiotypic monoclonal antibody of claim 1 binds to the antibody-containing sample, wherein binding indicates the presence of HIV-1 antibodies having a common idiotope.