Patent ID: 6086851
Filing Date: 2000-07-11
Classification: A61K,A61L,Y10S,Y10T

Abstract:
An interdigitation-fusion liposome prepared by a method which comprises the steps of:(a) preparing sized liposomes having an average diameter of less than about 0.40 microns and comprising a symmetrical saturated phospholipid;(b) combining the sized liposomes with an amount of an inducer effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid at a temperature and for a period of time effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid, so as to form an interdigitation-fusion gel from the sized liposomes; and,(c) incubating the interdigitation-fusion gel at a temperature above the transition temperature of the saturated phospholipid in the gel for a period of time effective to form an interdigitation-fusion liposome from the gel.