Patent ID: 7531569
Filing Date: 2009-05-12
Classification: A61K,A61P

Abstract:
1. A process for preparing compounds of the formula I wherein R1 and R2 R3 is Alk-R4 or trifluoromethyl; and salts thereof; which comprises a) formylating the amide of the formula IV and then cyclizing to the compound of the formula VI, b) reacting the compound of the formula VI with an alkoxycarbonylmethylene-triphenylphosphorane, with a 1-alkoxy-1-trimethylsiloxyethylene or with a trialkyl phosphonoacetate to give the compound of the formula VII, and c) reacting the compound of the formula VII with guanidine to give the compound of the formula I, where, in the compounds of the formulae IV, VI and VII, R1 to R3 are each as defined in formula I and R5 is alkoxy having 1, 2, 3 or 4 carbon atoms; and salts thereof.