Patent ID: 6537988
Filing Date: 2003-03-25
Classification: A61K,A61P,C07D,Y10S

Abstract:
A method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective amount of (1) at least one agent selected from the group consisting of anti-proliferative cytotoxic agents and cytostatic agents and (2) a compound of formula I or a pharmaceutically acceptable salt thereof whereinR1 is Cl, Br, CN, optionally substituted phenyl, or optionally substituted 2-,3- or 4-pyridyl; R2 is optionally substituted lower alkyl, or optionally substituted aralkyl; R3 and R5 are each independently optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted heterocyclo; R4 is hydrogen or lower alkyl; Z1 is CO, SO2, CO2 or SO2N(R5)â€”; and n is 1 or 2; provided that the cytotoxic agent and/or cytostatic agent is administered simultaneously with or prior to the formula I compound.