Patent ID: 6686458
Filing Date: 2004-02-03
Classification: C07F,G01N

Abstract:
A biarsenical molecule of general formula: and tautomers, anhydrides, and salts thereof;wherein each X1 or X2, independently, is Cl, Br, I, ORa, or SRa, or X1 and X2 together with the arsenic atom form a ring having the formula: Ra is H, C1-C4 alkyl, CH2 CH2OH, CH2COOH or CN; Z is 1,2-ethanediyl, 1,2-benzenediyl, 4-methyl-1,2-benzenediyl, 1,2-cyclopentanediyl, 1,2-cyclohexanediyl, 3-hydroxy-1,2-propanediyl, 3-sulfo-1,2-propanediyl, or 1,2-bis(carboxy)-1,2-ethanediyl; Y1 and Y2, independently, are H or CH3; or Y1 and Y2, together form a ring such that the biarsenical molecule has the formula: where M is O, S, CH2, C(CH3)2, or NH; R1 and R2, independently, are ORa, OAc, NRaRb, or H; R3 and R4, independently, are H, F, Cl, Br, I, ORa, or Ra; or R1 together with R3, or R2 together with R4, or both, form a ring in which (i) one of R1 or R3 is C2-C3 alkyl and the other is NRa and (ii) one of R2 and R4 is C2-C3 alkyl and the other is NRa; Rb is H, C1-C4 alkyl, CH2CH2OH, CH2COOH or CN; Q is CRaRb, CRaORb, C&boxH;O, or a spirolactone having the formula: wherein the spiro linkage is formed at C1, andwherein said molecule is substituted at one or more positions with a detectable group wherein said detectable group is selected from the group consisting of a fluorescent group, a luminescent group, spin label, photosensitizer group for singlet oxygen generation, photocleavable moiety, chelating center, heavy atom, radioactive isotope, isotope detectable by nuclear magnetic resonance and a paramagnetic atom.