Patent ID: 6569829
Filing Date: 2003-05-27
Classification: A61K,A61Q,C07C,C11D

Abstract:
A process for producing a N-(C8-C20)-acyl acidic amino acid, comprising a washing step of removing impurities by separating a mixture of the N-(C8-C20)-acyl acidic amino acid, which is obtained through the following steps, and which contains inorganic salts as impurities, and a medium consisting essentially of water and tertiary butanol into an aqueous layer and an organic layer containing the N-(C8-C20)-acyl acidic amino acid at a temperature of from 35 to 80Â° C.:1) an acylation reaction step of subjecting an acidic amino acid and a long chain fatty acid halide to condensation in a mixed solvent consisting essentially of water and tertiary butanol in the presence of an alkali, and 2) an acid precipitation separation step of adjusting a pH of the obtained reaction liquid to from 1 to 6 with a mineral acid to separate the mixture into an organic layer and an aqueous layer, thereby obtaining an organic layer containing the N-(C8-C20)-acyl acidic amino acid.