Patent ID: 8993742
Filing Date: 2015-03-31
Classification: C07K

Abstract:
1. An isolated nucleic acid molecule comprising a polynucleotide sequence encoding a fusion protein comprising a polypeptide of interest, wherein the polypeptide of interest is functionally linked to a heterologous tubulovesicular localization signal polypeptide and wherein said tubulovesicular localization signal polypeptide is selected from the group consisting of: (i) amino acid residues 1-145 of SEQ ID NO:1; (ii) amino acid residues 1-140 of SEQ ID NO:1; (iii) amino acid residues 1-135 of SEQ ID NO:1; and (iv) amino acid residues 1-130 of SEQ ID NO:1, wherein said tubulovesicular localization signal directs the polypeptide encoded by said polynucleotide to a tubulovesicular structure subcellular compartment in a cell.