Patent ID: 6071898
Filing Date: 2000-06-06
Classification: A61P,C07C,C07J,Y10S

Abstract:
A compound, or a pharmaceutically acceptable salt or ester thereof, represented by formula 1 ##STR12## wherein: R.sub.1 is chosen from a lower alkyl group having 1-4 carbon atoms, an alkoxy group having 1-4 carbon atoms, a hydroxymethyl group, a halomethyl group, an aldehyde group, and an aldehyde group protected by ethanedithiol;R.sub.2 is chosen from a lower alkyl group having 1-4 carbon atoms, a halomethyl group, a t-butyldimethylsilyloxymethyl group, a hydroxymethyl group, a hydroxymethyl group protected by an acetyl or benzoyl group, --CH.sub.2 OCOCHCHC.sub.6 H.sub.5 and --CH.sub.2 OCO(CH.sub.2).sub.n CO.sub.2 H, wherein n is chosen from 0, 1, 2 and 3;R.sub.3 is chosen from --H and --CH.sub.3 ; andwherein the double bond at the 2-position may be reduced,with the proviso that when R.sub.1 is --CHO and R.sub.2 is hydroxymethyl R.sub.3 is not --CH.sub.3.