Patent ID: 6632797
Filing Date: 2003-10-14
Classification: A61K

Abstract:
A method of treating angiogenesis in tumor conditions comprising administering to a mammal in need thereof an effective amount of a monosaccharide selected from the group consisting of D/L-ribose, D/L-arabinose, D/L-xylose, D/L-lyxose, D/L-allose, D/L-altrose, D/L-glucose, D/L-mannose, D/L-gulose, D/L-idose, D/L-galactose, D/L-talose, D/L-ribulose, D/L-xylulose, D/L-psicose, D/L-sorbose, D/L-tagatose, and D/L-fructose, in which said monosaccharide is substituted by at least three vicinal phosphorus containing radicals of the formula: whereinV1 to V4 are independently Y8m6To3U; T01 to T03 are independently (CH2)n, CH&boxH;CH, or CH2CH&boxH;CHCH2; o1 to o3 are independently 0 or 1; n is 0 to 4; U is R1Y9m7, CY10Y11R2,SY12Y13Y14R3,PY15Y16Y17R4R5, Y18PY19Y20Y21R6R7, CH2NO2, NHSO2R8, or NHCY22Y23R9; m1 to m7 are independently 0 or 1; Y1 to Y23 are independently NR10, NOR11, O, or S; and where R1 or 11 are independently i) hydrogen; ii) a straight or branched saturated or unsaturated alkyl group containing 1-22 carbon atoms; iii) a saturated, unsaturated aromatic or non-aromatic homo- or heterocyclic group containing 3-22 carbon atoms and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; iv) a straight or branched saturated or unsaturated alkyl group containing 1-22 carbon atoms substituted with a saturated or unsaturated aromatic or non-aromatic homo- or heterocyclic group containing 3-22 carbon and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; v) an aromatic or non-aromatic homo-or heterocyclic group containing 3-22 carbon and 0-5 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur which aromatic or non-aromatic homo-or heterocyclic group is substituted with a straight or branched saturated or unsaturated group containing 1-22 carbon atoms; whereby said groups in ii-v are unsubstituted or are substituted by 1-6 of the following groups: hydroxy, alkoxy, aryloxy, acyloxy, carboxy, alkoxycarbonyl, alkoxycarbonyloxy, aryloxycarbonyl, aryloxycarbonyloxy, carbamoyl, fluoro, chloro, bromo, azido, cyano, oxo, oxa, amino, imino, alkylamino, arylamino, acylamino, arylazo, nitro, alkylthio or alkylsulfonyl.