Patent ID: 6699850
Filing Date: 2004-03-02
Classification: A61K,A61P

Abstract:
A pharmaceutical composition suitable for inhibiting bone resorption in a mammal in a need thereof comprising from about 1 to about 100 mg of a nitrogen-containing bisphosphonate or a pharmaceutically acceptable salt thereof and from about 0.1 to about 10 mg of an isoprenoid compound of the formula: wherein R2 is selected from the group consisting of H, C1-C30 alkyl selected from straight, branched, and cyclic alkyl, C2-C30 alkenyl selected from straight, branched, and cyclic alkenyl, C2-C30 alkynyl selected from straight, branched, and cyclic alkyl, C5-C14 aryl, and C&boxH;Oâ€”R3, wherein R3 is selected from the group consisting of H, C1-C10 alkyl selected from straight, branched, and cyclic alkyl, C2-C10 alkenyl selected from straight, branched, and cyclic alkenyl C2-C10 alkynyl selected from straight, branched, and cyclic alkynyl, C2-C10 hydroxy-substituted alkyl selected from straight, branched, and cyclic, C2-C10 amino-substituted alkyl selected from straight, branched, and cyclic, C2-C10 carbonylhydroxy-substituted alkyl selected from straight, branched, and cyclic, and C5-C14 aryl, and n is an integer from 0 to 3, wherein the composition being is also suitable for mitigating the gastrointestinal side effects associated with bisphosphonate therapy.