Patent ID: 7846437
Filing Date: 2010-12-07
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting Vascular Endothelial Growth Factor-D (VEGF-D) mediated cell growth, migration, or differentiation, comprising administering to a human subject an antibody that specifically binds VEGF-D, wherein the antibody is administered in an amount effective to inhibit VEGF-D interaction with VEGFR-2 or VEGFR-3, and wherein the antibody comprises a light chain variable region comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 37; a heavy chain variable region comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 39; a human antibody light chain constant region; and a human antibody heavy chain constant region.