Patent ID: 7648959
Filing Date: 2010-01-19
Classification: A61K,A61P

Abstract:
1. A method for treatment of a patient to inhibit or reduce angiogenesis or neovascularization in the eye comprising injecting a therapeutically effective amount of an α v β 3 and/or α v β 5 inhibitor, sufficient to inhibit or reduce angiogenesis or neovascularization in the treated eye, into the sclera layer of the eye of the patient through the location of the exterior surface of the sclera that overlies retinal tissue, wherein the α v β 3 and/or α v β 5 inhibitor is a compound of formula II wherein R R R R R R R X, Y are each independently of one another ═N—, —N—, O, S, —CH W, Z are each independently of one another absent, O, S, NR R R R R A, A′ are each independently of one another H or unsubstituted or mono-, di- or tri-R Ar is an unsubstituted or mono-, di- or tri-A- and/or R Hal is F,Cl,Br or I and m, n are each independently of one another 0, 1, 2, 3 or 4, or a physiologically acceptable salt thereof.