Patent ID: 6548706
Filing Date: 2003-04-15
Classification: C07C

Abstract:
A process for the preparation of a compound having the following general formula: said process comprising: combining a halomethyl alcohol (HMA) with an amine and an acid scavenger to form a reaction mixture, and heating said reaction mixture until the reaction is complete, thereby forming the compound of Formula I; wherein said HMA has the following general formula: wherein:R1 is an amino acid side chain or a functionalized amino acid side chain; R2 is a protecting group; R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and â€”NHP, wherein P is selected from the group consisting of H, alkyl, cycloalkyl, aryl and a protecting group, or R3 and R4 together form a cyclic structure selected from the group consisting of quinoline and isoquinoline; and X is a leaving group.