Patent ID: 8877928
Filing Date: 2014-11-04
Classification: A61K,A61P,C08G,C08L

Abstract:
1. A PEGylated cyclopamine analog comprising a compound represented by the following formula I: or a single enantiomer thereof, a mixture of enantiomers, or a mixture of diastereomers, or a pharmaceutically acceptable salt thereof, wherein: R is straight or branched polyethylene glycol having a molecular weight of 200 to 200,000 Dalton, L is a linking group represented by the following formula II: wherein R Y is selected from the group consisting of O, N, S—S, methylene, and ethylidene; m is an integer of 0-6; X is a linking group between cyclopamine and L, which is selected from the group consisting of —C(O), —OC(O), —NHC(O), —OS(O)