Patent ID: 6090807
Filing Date: 2000-07-18
Classification: A61K,A61P

Abstract:
A composition for treating disorders which respond to dopamine D.sub.3 receptor antagonists or agonists which comprises a pharmaceutical aid and an effective amount of a compound of the formula I:Het--A--B--ArwhereA is a straigh chain or branched C.sub.3 -C.sub.8 -alkylene group which contains at least one group which is selected from among O, S, NR.sup.4, CONR.sup.4, NR.sup.4 CO, COO, and OCO,B is a radical of the formula: ##STR59## Ar is a phenyl, pyridyl, pyrimidyl or triazinyl, where Ar may have one to four substituents selected from the group consisting of OR.sup.4, C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.8 -alkenyl, C.sub.2 -C.sub.8 -alkynyl, halogen, CN, CO.sub.2 R.sup.4, NO.sub.2, SO.sub.2 R.sup.4, SO.sub.3 R.sup.4, NR.sup.4 R.sup.5, SO.sub.2 NR.sup.4 R.sup.5, SR.sup.4, CF.sub.3, CHF.sub.2, a 5- or a 6-membered carbocyclic, aromatic or non-aromatic ring and a 5- or a 6-membered heterocyclic, aromatic or non-aromatic ring having 1 to 3 hetero atoms which are selected from O, S and N, where the carbocyclic or the heterocyclic ring is unsubsfituted or substituted by C.sub.1 -C.sub.8 -alkyl, halogen, OC.sub.1 -C.sub.8 -alkyl, OH, NO.sub.2 or CF.sub.3, and where Ar may also be fused to a 5- or 6-membered carbocyclic, aromatic ring or to a 5- or 6-membered heterocyclic, aromatic or non-aromatic ring having 1 to 3 heteroatoms which are selected from O, S and N, where the carbocyclic or the heterocyclic ring is unsubstituted or substituted by C.sub.1 -C.sub.8 -alkyl, halogen, OC.sub.1 -C.sub.8 -alkyl, OH, NO.sub.2 or CF.sub.3,Het is a group ##STR60## where R.sup.1, R.sup.2 and R.sup.3 are, independently of one another, H, halogen, OR.sup.5, NR.sup.4 R.sup.5, SR.sup.4, CF.sub.3, CN or C.sub.1 -C.sub.8 -alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.8 -alkyl or halogen,R.sup.4 is H or C.sub.1 -C.sub.8 -alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.8 -alkyl or halogen,R.sup.5 is the meaning indicated for R.sup.4 or is COR.sup.4 or CO.sub.2 R.sup.4 ;and the salts thereof with physiologically tolerated acids.