Patent ID: 8216299
Filing Date: 2012-07-10
Classification: A61F,A61L

Abstract:
1. A method for remodelably retracting the interior wall of a body vessel by inducing contraction of a remodelable extracellular matrix material during a remodeling process on the interior wall of the body vessel, the method comprising: (a) inserting a delivery system including a remodelable extracellular matrix material without a support frame annularly disposed around a portion of a catheter into a vein, wherein the remodelable extracellular matrix material is isolated from a tissue source and has an implantable first size; (b) advancing the delivery system to a point of treatment within the vein; (c) implanting the remodelable extracellular matrix material in contact with an interior wall of a body vessel at the point of treatment within the vein to induce inward retraction of the body vessel wall with said inward retraction beginning only after said implanting of the remodelable extracellular matrix material and only upon remodeling of the remodelable extracellular matrix material, the point of treatment being in the superficial venous system or the deep venous system at a treatment-effective distance of up to about 50 mm from a base of a valve leaflet within the vein to remodelably retract the interior wall of the vein at the base of the valve leaflet radially toward the center of the lumen of the body vessel, and (d) maintaining the remodelable extracellular matrix material in contact with the interior wall of the body vessel for a time sufficient for the remodelable extracellular matrix material to undergo contraction after said implanting and during remodeling by patient tissue such that the size of the remodelable extracellular matrix material is reduced relative to its implantable first size, wherein said contraction during remodeling is effective after said implanting to pull a portion of the body vessel radially inward within the lumen of the body vessel to reduce the volume of the body vessel lumen at the point of treatment.