Patent ID: 8969319
Filing Date: 2015-03-03
Classification: A61K,A61P

Abstract:
1. A method for the reduction of a corneal epithelial layer disorder, comprising administering to a subject in need thereof an effective amount of a glycosaminoglycan into which a hydrophobic group is introduced via a binding chain into a repeating unit of the glycosaminoglycan with a degree of substitution of 10% to 20% in molar equivalent of the glycosaminoglycan, wherein the glycosaminoglycan is hyaluronic acid or a salt thereof, the binding chain is —CONH—, the hydrophobic group is a phenylethenyl group, the glycosaminoglycan into which a hydrophobic group is introduced via a binding chain further includes a spacer chain between the binding chain and the hydrophobic group, wherein the spacer chain is —(CH 2 ) 3 —OC(═O)—, wherein said glycosaminoglycan into which a hydrophobic group is introduced contains repeating units of formula (I): wherein R is —OH, —NH—(CH wherein said corneal epithelial layer disorder is corneal xerosis, keratoconjunctivitis, superficial punctate keratitis, corneal epithelial erosion, or corneal epithelial loss.