Patent ID: 6433172
Filing Date: 2002-08-13
Classification: A61P,C07B,C07C,C07D

Abstract:
A method for stereospecifically preparing a [(1-optionally substituted arylsoulfonyl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amine, having chirality at the 2-position, comprising reacting a 2-amino-2-substituted ethyl alcohol, having chirality at the 2-position, with an [(optionally substituted aryl)- or (trihalomethyl) sulfonyl]-halide or anhydride in the presence of a base to form an [(N-arylsulfonyl)- or (N-trihalomethylsulfonyl)]-2-substituted aziridine having chirality at the 2-position.