Patent ID: 6825196
Filing Date: 2004-11-30
Classification: C07D,Y02P

Abstract:
A method of improving the stability of a hydralazine composition during manufacturing or storage comprising coupling an N-protecting group with hydralazine to produce a compound having the formula: or a compound having the formula: where R1 and R2 are independently H, substituted or unsubstituted branched or straight chain alkyl having from 1 to about 7 carbon atoms, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted alkylcycloalkyl, lower alkenyl or R1 and R2 together form part of a substituted or unsubstituted cycloalkyl having from about 4 of about 7 carbon atoms; where R3 is a branched or straight chain alkyl having from 1 to about 7 carbon atoms, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted cycloalkyl, aralkyl, substituted or unsubstituted alkylcycloalkyl or a group having the formula (CH2)nCOOH where n is from 1 to about 7; andwherein said N-protecting group is labile and is removed from said compound after manufacturing or storage and prior to administration of said compound to a patient.