Patent ID: 8697604
Filing Date: 2014-04-15
Classification: C07B,C07C,C07D,C07K,C40B,G01N,Y10T

Abstract:
1. An array of mass tags comprising: at least two mass tag reagents, each mass tag reagent in the array being adapted to label a molecule to be characterized by mass spectrometry and having the following formula: wherein R the reactive functionality RF is selected from the group consisting of active esters of carbonic acids, alkenyl sulphones, haloalkanes, maleimides, isocyanates, isothiocyanates, ketones, aldehydes, sulphonyl-halides, carboxylic-halides, anhydride esters, alkenes, N- hydroxysuccinimide esters, hydroxybenzotriazole esters, hydroxyazabenzotriazole esters, nitrophenyl esters, trichlorophenyl esters and pentafluorophenyl esters; and the linker L is selected from —CH wherein each mass tag reagent in the array has a modified isotone distribution, wherein the isotope disiribution is modified via an isotope replacement selected from the group consisting of one or more of