Patent ID: 6333343
Filing Date: 2001-12-25
Classification: A61P,C07D,C07F

Abstract:
A nitrogen heterocyclic aromatic derivative having the following general formula: ##STR23##where X and Y are selected from N, C and CH, provided they are different from each other, or X and Y are both nitrogen;R is hydrogen or --COR.sub.8 where R.sub.8 is a saturated or non-saturated C.sub.1 -C.sub.10 alphatic hydrocarbon, R.sub.1 has the following general formula: ##STR24##where R.sub.3 is hydrogen, halogen, C.sub.1 -C.sub.10 alkyl or C.sub.1 -C.sub.10 alkoxyl, R.sub.4 is hydrogen, C.sub.1 -C.sub.10 alkyl or C.sub.1 -C.sub.10 alkoxyl, or R.sub.3 and R.sub.4 together form a methylendioxy group;R.sub.2 has the following general structure: ##STR25##and R.sub.5 is selected from: ##STR26##where Z=OR.sub.7 where R.sub.7 is a saturated or non-saturated, linear or branched C.sub.1 -C.sub.10 aliphatic hydrocarbon, or R.sub.7 has the following formula: ##STR27##where R, R.sub.1, X and Y are defined as above and R.sub.6 is hydrogen, halogen, alkyl or alkoxyl C.sub.1 -C.sub.10, or Z is NHR.sub.8 where R.sub.8 is a linear or branched C.sub.1 -C.sub.20 alkyl chain,provided that when X=Y=N and R is H or --CONHCH.sub.2 CH.sub.3, Z is not NHR.sub.8 where R.sub.8 is --CH.sub.2 CH.sub.3, and provided that R.sub.1 and R.sub.2 are not located on two adjacent atoms of the heterocyclic aromatic ring, and further provided that when X=Y=N and R.sub.5 is --COZ where Z=OR.sub.7, R.sub.7 is a saturated or non-saturated linear or branched C.sub.5 -C.sub.20 aliphatic hydrocarbon.