Patent ID: 6465507
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of Formula (I): wherein:(a) each R1 is independently and optionally selected from the group consisting of: (i) hydrogen; (ii) saturated or unsaturated alkyl optionally substituted with one, two or three substituents selected from the group consisting of halogen, trihalomethyl, alkoxy, carboxylate, amino, nitro, ester, and a five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where each ring is optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (iii) an aromatic or heteroaromatic ring optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (iv) an aliphatic or heteroaliphatic ring optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, ester, and an aromatic or heteroaromatic ring optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (v) an alcohol of formula â€”(X1)n1â€”OH or an alkoxyalkyl of formula â€”(X2)n2â€”Oâ€”X3, where X1, X2, and X3 are independently selected from the group consisting of saturated or unsaturated alkyl, amide, and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the alkyl, and each ring is optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, alkoxy, aryl, heteroaryl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; and n1 and n2 are independently 0 or 1; (vi) a halogen or trihalomethyl; (vii) a carboxylic acid of formula â€”(X4)n4â€”COOH or ester of formula â€”(X5)n5â€”COOâ€”X6, where X4, X5, and X6 are independently selected from the group consisting of alkyl and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring; and n4 and n5 are independently 0 or 1; (viii) an amide or thioamide of formula â€”(X7)n7â€”NHCOX8, â€”(X7)n7â€”NHCSX8, â€”(X9)n9â€”CONX10X11, or of formula â€”(X9)n9â€”CSNX10X11, where X7 and X9 are each independently selected from the group consisting of alkyl and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where each of the ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; n7 and n9 are independently 0 or 1; and X8, X10, and X11, are each independently selected from the group consisting of hydrogen, alkyl, hydroxyl, alkoxy, and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, thioalkyl, aryl, heteroaryl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; or where X10 and X11 taken together form a five-membered or six-membered aliphatic or heteroaliphatic ring or a fused bicyclic ring optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (ix) a sulfonamide of formula â€”(X12)n12â€”SO2NX13X14 or of formula â€”(X12)n12â€”NX13â€”SO2â€”X14, where X12 is selected from the group consisting of alkyl, and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the alkyl and each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, hydroxy, trihalomethyl, carboxylate, amino, nitro, and ester; n12 is 0, 1, or 2; and X13, and X14 are independently selected from the group consisting of hydrogen, alkyl, and three-, four-, five-, or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the alkyl and each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, aryl, heteroaryl, halogen, trihalomethyl, aldehyde, carboxylate, amino, nitro, and ester; or where X13 and X14 taken together form a five-membered or six-membered aliphatic or heteroaliphatic ring or a fused bicyclic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (x) a sulfone of formula â€”(X15)n15â€”SO3H, where X15 is selected from the group consisting of alkyl, and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the alkyl and each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; n15 is 0, 1, or 2; and (xi) an amine of formula â€”(X16)n16â€”NX17X18, where X16 is selected from the group consisting of saturated or unsaturated alkyl, and five-membered or six-membered aromatic, heteroaromatic, or aliphatic ring; n16 is 0 or 1; and X17 and X18, are independently selected from the group consisting of hydrogen, saturated or unsaturated alkyl, and five-membered or six-membered aromatic, heteroaromatic, or aliphatic ring where each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (xii) a ketone of formula â€”(X19)n19â€”COâ€”X20, where X19 and X20 are independently selected from the group consisting of alkyl and five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where the alkyl and each ring is optionally substituted with one, two, or three substituents independently selected from the group consisting of alkyl, five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; and n19 is 0 or 1; (xiii) a nitro group of the formula â€”NO2; or (xiv) two adjacent R1 groups together along with two adjacent A, B, D, or E form an optionally substituted five-membered or six-membered aliphatic or heteroaliphatic ring; (b) R2 and R4 are each independently selected from the group consisting of (i) hydrogen; (ii) saturated or unsaturated alkyl optionally substituted with one, two or three substituents selected from the group consisting of halogen, trihalomethyl, carboxylate, amino, nitro, ester, and a five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (iii) an aromatic or heteroaromatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; and (iv) an aliphatic or heteroaliphatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, ester, and an aromatic or heteroaromatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (c) R3 and R5 are each independently selected from the group consisting of (i) hydrogen; (ii) saturated or unsaturated alkyl optionally substituted with one, two or three substituents selected from the group consisting of hydroxy, halogen, trihalomethyl, carboxylate, amino, nitro, ester, and a five-membered or six-membered aromatic, heteroaromatic, aliphatic, or heteroaliphatic ring where each ring is optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (iii) an aromatic or heteroaromatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; and (iv) an aliphatic or heteroaliphatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, ester, and an aromatic or heteroaromatic ring optionally substituted with one, two or three substituents independently selected from the group consisting of alkyl, alkoxy, halogen, trihalomethyl, carboxylate, amino, nitro, and ester; (d) A, B, D, and E are each independently carbon or nitrogen provided that none, one, or, two of A, B, D, and E is nitrogen; and provided that when any of A, B, D, or E is nitrogen, no R1 is attached to said A, B, D, or E; (e) G is nitrogen or oxygen, with the proviso that when G is oxygen, R5 is absent; (f) m is 2, 3, or 4; and (h) q is 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.