Patent ID: 6515001
Filing Date: 2003-02-04
Classification: A61K

Abstract:
A method of treating a chemokine mediated disease state, or a disease state mediated by a receptor of the chemokine, in a mammal in need of such treatment, which comprises administering to the mammal an effective amount of a compound of the formula (I), or a pharmaceutically acceptable salt thereof: wherein:â€œaâ€  is 0 or an integer from 1 to 4; â€œbâ€  is 0 or an integer from 1 to 4; â€œcâ€  at each occurance is independently 0 or an integer from 1 to 3; Ring A is aromatic and is heterocyclic, wherein X is one or more heteroatoms selected from the group consisting of oxygen and nitrogen; Ring B is aromatic or non-aromatic and is substituted at different positions by the groups consisting of alkyl, alkenyl, alkynyl, amino, amido, thio, thiazolo, imidazolo, or aromatic hydrocarbons; R1 and R2 at each occurance is independently selected from substituents having 50 or fewer atoms, wherein the substituent is selected from the group consisting of: H; substituted or unsubstituted alkyls, C1-10 alkyls, C1-6 alkyls; substituted or unsubstituted cycloalkyls, C3-6 cycloalkyls; substituted or unsubstituted alkenyls, C2-6 alkenyls; substituted or unsubstituted alkynyls, C2-6 alkynyls; substituted or unsubstituted aryls; substituted or unsubstituted heterocycles; hydroxyls; aminos; nitros; thiols; primary, secondary or tertiary amines; imines; amides; phosphonates; phosphines; carbonyls; carboxyls; silyls; ethers; thioethers; sulfonyls; sulfonates; selenoethers; ketones; aldehydes; esters; â€”CF3; â€”CN; and combinations thereof; R3, at each occurance is independently selected from substituents having 18 or fewer atoms, wherein the substituent is selected from the group consisting of: H; substituted or unsubstituted alkyls, C1-5 alkyls; substituted or unsubstituted cycloalkyls, C3-5 cycloalkyls; substituted or unsubstituted alkenyls, C2-5 alkenyls; substituted or unsubstituted alkynyls, C2-6 alkynyls; substituted or unsubstituted aryls; benzyl and benzyl esters; substituted or unsubstituted heterocycles; hydroxyls; aminos; nitros; thiols, primary, secondary or tertiary amines; imines; amides; imidazoles; thiazoles; phosphonates; phosphines; carbonyls; carboxyls; silyls; ethers; thioethers; sulfonyls; sulfonates; selenoethers; ketones; aldehydes; esters; â€”CF3; â€”CN; and combinations thereof; R4 is a thiazole; and, wherein the chemokine is selected from the group consisting of: IL-8, and chemokines that bind to a chemokine receptor in a mammal selected from the group consisting of CXCR-1, and CXCR-2.