Patent ID: 7803560
Filing Date: 2010-09-28
Classification: A61K,A61P,C07K

Abstract:
1. A method to identify an antagonist of MCP-1R, comprising: (a) contacting an isolated MCP-1R polypeptide with a candidate antagonist, wherein the MCP-1R polypeptide comprises an amino acid sequence at least 95% homologous to an extracellular domain of SEQ ID NO: 2 or of SEQ ID NO: 4, and (b) comparing the binding of MCP-1 to the MCP-1R polypeptide in the presence of the candidate antagonist to the binding of MCP-1 to the MCP-1R polypeptide in its absence; wherein a candidate antagonist which causes a decrease in the binding of MCP-1 to the MCP-1R polypeptide is identified as an antagonist of MCP-1R.