Patent ID: 7989422
Filing Date: 2011-08-02
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method of inhibiting bacterial growth comprising contacting bacteria with at least one monosaccharide compound, or a pharmaceutically acceptable salt thereof, of formula (1): wherein, n is 1; the ring is of the galacto-configuration and the anomeric center may be of either the α or β configuration; R1 is selected from the group consisting of hydrogen; OZ; SZ; OPO Y is selected from hydrogen, or the following, where G denotes the point of connection to the nitrogen atom in N(Y)Z; Q is selected from hydrogen or W; the groups W are independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl, of 1 to 20 carbon atoms, each of which is optionally substituted, branched and/or linear; wherein W is optionally substituted by one or more substituents selected from the group consisting of OH, NO, NO each occurrence of Z is independently selected from the group consisting of: hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl, of 1 to 20 carbon atoms, each of which is optionally substituted, branched and/or linear; wherein Z is optionally substituted by one or more substituents selected from the group consisting of OH, NO, NO wherein each occurrence of U is independently selected from the group consisting of: OH, NO, NO wherein the groups R2, R3, and R5 are independently selected from OZ or N-Het, wherein N and Het combine to form a heterocycle which may be further substituted with U groups; or N(Z)Y or OPO wherein R4 is N-Het, wherein N and Het combine to form a heterocycle which may be further substituted with U groups.