Patent ID: 8834951
Filing Date: 2014-09-16
Classification: A01N,A23K,A23L,A23V,A23Y,A61K,A61P,C12Y

Abstract:
1. A method for preparing a dry glassy composition without boiling or foaming, said method comprising: (a) combining a bioactive material, a matrix forming agent and two glass forming agents in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles in a form of beads, droplets or strings; (c) primary drying the frozen particles by evaporation, under vacuum, and at a temperature above the freezing point of the frozen particles, wherein the pressure is greater than 2,000 mTORR, wherein the temperature of the particles is greater than −10° C., whereby a primarily dried formulation is formed; and (d) secondary drying the primarily dried formulation at full vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity of the primarily dried formulation to Aw −0.3 or lower, whereby the dry glassy composition is prepared.