Patent ID: 6828326
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of: a pharmaceutically acceptable salt thereof, wherein A is â€”NR(C&boxH;O), â€”(C&boxH;O)NR, (C2-C6)alkynyl-, or a bond; wherein each R, R1, R2, R3, R5, and R6 are the same or different, where ever they appear, and each is independently selected from the group consisting of (C1 -C6)alkyl-, (C2-C6)alkenyl-, (C2-C6)alkynyl-, (C3-C10)cycloalkyl-, (C6-C10)aryl-, (C1-C10)heterocyclyl-, (C1-C10)heteroaryl-, (C3-C10)cycloalkyl-(C1-C6)alkyl-, (C6-C10)aryl-(C1-C6)alkyl-, (C1-C10)heterocyclyl-(C1-C6)alkyl-, (C1-C10)heteroaryl-(C1-C6)alkyl-, (C3-C10)cycloalkyl-(C2-C6)alkenyl-, (C6-C10)aryl-(C2-C6)alkenyl-, (C1-C10)heterocyclyl-(C2-C6)alkenyl-, (C6-C10)aryl-(C2-C6)alkenyl-, (C1-C10)heteroaryl-(C2-C6)alkenyl-, C3-C10)cycloalkyl-(C2-C6)alkynyl-, (C6-C10)aryl-C2-C6)alkynyl-, C1-C10)heterocyclyl-C2-C6)alkynyl-, (C1-C10)heteroaryl-(C2-C6)alkynyl-; wherein each of the aforesaid group members, (C1-C6)alkyl-, (C2-C6)alkenyl-, (C2-C6)alkynyl-, (C3-C10)cycloalkyl-, (C6-C10)aryl-, (C1 -C10)heterocyclyl-, C1-C10)heteroaryl-, C3-C10)cycloalkyl-C1-C6)alkyl-, (C6-C10)aryl-(C1-C6)alkyl-, (C1-C10)heterocyclyl-(C1-C6)alkyl-, (C1-C10)heteroaryl-(C1-C6)alkyl-, C3-C10)cycloalkyl-(C2-C6)alkenyl-, (C6-C10)aryl-(C2-C6)alkenyl-, (C1-C10)heterocyclyl-(C2-C6)alkenyl-, (C6-C10)aryl-(C2-C6)alkenyl-, (C1-C10)heteroaryl-(C2-C6)alkenyl-, C3-C10)cycloalkyl-(C2-C6)alkynyl-, (C6-C10)aryl-(C2-C6)alkynyl-, (C1-C10)heterocyclyl-(C2-C6)alkynyl-, and (C1-C10)heteroaryl-(C2-C6)alkynyl-, may be optionally independently substituted with one to three suitable substituents selected from the group consisting of hydrogen, halogen, hydroxy, â€”CN, (C1-C4)alkyl-, (C1-C4)alkoxy-, CF3â€”, CF3Oâ€”, (C6-C10)aryl-, (C1-C10)heteroaryl-, (C6-C10)aryl-(C1-C4)alkyl-, (C1-C10)heteroaryl-(C1 -C4)alkyl-, HO(C&boxH;O)â€”, (C1-C4)alkyl-(O)(C&boxH;O)â€”, (C1-C4alkyl-(O)(C&boxH;O)(C1-C4)alkyl-, C1-C4)alkyl-(C&boxH;O)â€”, (C1-C4)alkyl-(C&boxH;O)(C1-C4)alkyl-, â€”(S&boxH;O)R, â€”(SO2)R, and NR7R8 wherein R7 and R8 are independently selected from hydrogen, (C1-C6)alkyl; R, R3, R5, and R6 may further be hydrogen; and R4 is selected from the group consisting of hydrogen and (C1-C6)alkyl-, and R4 may be optionally substituted with one to three suitable substituents selected from the group consisting of halogen, hydroxy, â€”CN, CF3â€”, and CF3Oâ€”.