Patent ID: 7115398
Filing Date: 2006-10-03
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated nucleic acid molecule which comprises DNA having at least 95% nucleic acid sequence identity to: (a) a nucleotide sequence that encodes amino acid residues 1 to 197 of SEQ ID NO:3, (b) a nucleotide sequence that encodes amino acid residues 19 to 197 of SEQ ID NO:3, (c) the nucleotide sequence from position 50 to 640 of SEQ ID NO:4, (d) the nucleotide sequence from position 104 to 640 of SEQ ID NO:4, (e) the full-length coding sequence of the cDNA deposited under ATCC accession number 203552, or (f) the full-length coding sequence of the cDNA deposited under ATCC accession number 203552 lacking its associated signal peptide encoding region; wherein said isolated nucleic acid molecule encodes a polypeptide capable of inducing the production of TNF-α in human leukemia monocytic THP-1 cells.