Patent ID: 8999169
Filing Date: 2015-04-07
Classification: A61K,A61P,G01N

Abstract:
1. A method of determining a dosage of phosphorus binder for a patient undergoing dialysis treatment to achieve a pre-dialysis serum phosphorus concentration within a desired concentration range while achieving a desired net accumulation of calcium, comprising: a) calculating an intradialytic calcium mass balance for the patient; b) calculating an intradialytic phosphorus mass balance for the patient; c) establishing a phosphorus kinetic model using the intradialytic calcium mass balance and intradialytic phosphorus mass balance determined in a) and b); d) using the phosphorus kinetic model to determine a dosage of phosphorus binder that will achieve a pre-dialysis serum phosphorus concentration of the patient that is within the desired concentration range while accounting for the change in the amount of phosphorus which will be removed by the dialysis treatment when the pre-dialysis serum phosphorus concentration of the patient is within the desired concentration range; e) using the phosphorus kinetic model to determine a dialysate calcium concentration that will result in the desired net accumulation of calcium in the patient over a complete dialysis cycle; and f) dialyzing the patient with a dialysate containing a calcium concentration based upon the concentration determined in step e).