Patent ID: 9155740
Filing Date: 2015-10-13
Classification: A61K,A61P

Abstract:
1. A method of improving nitric oxide bioavailability in renal arteriole and glomerular cells to treat uric acid-induced diabetic nephropathy in a patient in need, wherein said patient in need has diabetes, a uric acid level higher than 5.5 mg/dl, impaired endothelial function, and elevated albumin excretion, said method comprising administering to said patient a composition comprising a uric acid lowering agent (UALA) according to a regimen effective to maintain said patient's average serum uric acid level at or below 5.5 mg/dl and to increase nitric oxide bioavailability in renal arteriole and glomerular cells, wherein said UALA is a xanthine oxidase inhibitor.