Patent ID: 8017105
Filing Date: 2011-09-13
Classification: A61B,A61K,C07F

Abstract:
1. A composition of matter having the following formula: or a pharmaceutically acceptable salt thereof, wherein PPBM is a plasma protein binding moiety, wherein the plasma protein is human serum albumin (HSA); wherein the PPBM has 7-18 carbon atoms and comprises at least 1 aryl ring selected from phenyl, napthyl, biphenyl, and benzyl; wherein IEM is an image enhancing moiety and is selected from the following group: wherein one of R wherein R wherein R wherein said M is a paramagnetic metal ion chelated by the IEM and selected from the group consisting of Gd(III), Fe(III), Mn(II), Mn(III), Cr(III), Cu(II), Dy(III), Tb(III), Ho(III), Er(III), and Eu(III); wherein L is a linker connecting the IEM to the BHEM consisting of 1 to 4 —CH wherein the BHEM moiety is a blood half-life extending moiety and is a phosphodiester.