Patent ID: 8779198
Filing Date: 2014-07-15
Classification: C07C,Y02P

Abstract:
1. A process of opening the ring of a ring-containing compound which comprises reacting a ring-containing compound possessing at least one lactone ring with at least one amine in the presence of at least one monocarboxylic acid in the amount of from 0.5 equivalents to 1.5 equivalents to the molar amount of said ring-containing compound, without the presence of a metal salt catalyst, and under conditions sufficient to open the at least one ring and provide ring-opened reaction product, wherein the ring containing compound possessing the at least one lactone ring is selected from the group consisting of γ-decanolactone, β-butyrolactone, δ-decanolactone, β-propiolactone, D -glucono-δ-lactone, ε-caprolactone, δ-caprolactone, γ-butyrolactone, γ-caprolactone, 4R,4aS,7R,7aR)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-7-methoxy-2,2-dimethyldihydro-4H-furo[3,2-d][1,3]dioxin-6(4aH)-one, (3aR,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]-dioxol-4(3aH)-one, (3aR,4S,5R,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)hexahydro-2H-cyclopenta[b]furan-2-one, and 1,1-dimethylethyl[(1S,3S)-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate wherein the at least one amine is of the formula H wherein the at least one monocarboxylic acid is of the general formula RCOOH wherein R is alkyl, cycloalkyl, alkenyl, aryl, substituted aryl or aralkyl of up to 30 carbon atoms, optionally substituted with at least one halogen atom.