Patent ID: 7160903
Filing Date: 2007-01-09
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A method of treating a disorder in the course of which an increased activity of a matrix-degrading metalloproteinase is obtained, the method comprising administering to a host in need thereof an efficacious amount of at least one compound of formula (I) a stereoisomeric form of the compound of formula (I), or a physiologically tolerable salt of the foregoing, wherein R R R m is defined above, —(CH R in which r is the integer 1, 2, or 3, the ring is unsubstituted, or one of the carbon atoms in the ring is replaced by —O—, or —S—, and the carbon atoms are unsubstituted, or are mono- or polysubstituted by (C in which r is the integer 1, 2, or 3, the ring is unsubstituted, or one of the carbon atoms in the ring is replaced by —(R A is B is X is a sulfur atom, wherein the disorder is a collagenose, immunologically or metabolically related acute or chronic arthritide, or arthropathy.