Patent ID: 7291455
Filing Date: 2007-11-06
Classification: A01N,C12Q

Abstract:
1. A method of diagnosing risk of HPV18-induced neoplasia by detecting HPV18-induced cell transformation in a patient infected with HPV comprising the steps of: quantifying levels of at least two HPV18 mRNAs from a sample collected from said patient, wherein said mRNAs comprise a first mRNA selected from the group consisting of E6 mRNA and E7 mRNA and a second mRNA selected from the group consisting of E2 mRNA, L1 mRNA, and L2 mRNA; and determining a ratio of E6 and/or E7 mRNA to L1 and/or L2 and/or E2 mRNA, wherein any ratio of greater than 2 is indicative of HPV18-induced cell transformation and risk of neoplasia.