Patent ID: 7018818
Filing Date: 2006-03-28
Classification: C07B,C07C,Y02P

Abstract:
1. A process for the preparation of a compound of formula (IV) or (IVA) from a compound of formula (I) or (IA) where R represents H or a suitable carboxylic acid protecting group comprising the reaction: (i) where R is H, enzymatic hydrolysis of a compound of formula (I) or (IA), where R is a carboxylic acid protecting group; or (ii) where R is a carboxylic acid protecting group, enzymatic esterification of a compound of formula (I) or (IA) where R is H; or (iii) chromatographic resolution of the isomers of a compound of formula (I) or (IA); or (iv) where R is a carboxylic acid protecting group, by enzymatic hydrolysis of a compound of formula (I) or (IA) where R is a carboxylic acid protecting group, followed by re-esterificarion; or (v) where R is a carboxylic acid protecting group, by removal of the undesired stereoisomer of a compound of formula (I) or (IA) where R is a carboxylic acid protecting group by enzymatic hydrolysis.