Patent ID: 6706701
Filing Date: 2004-03-16
Classification: C07J,Y02P,Y10S

Abstract:
A compound of the formula: or pharmaceutically acceptable salts or solvates thereof, wherein:each of C1, C2, C4, C11, C12, C15 and C16 is independently substituted according to any of (a) and (b): (a) one of: &boxH;O, &boxH;C(R4)(R4), â€”C(R4)(R4)(C(R4)(R4))nâ€” and â€”(O(C(R4)(R4))nO)â€” wherein n ranges from 1 to about 6; (b) two of: â€”X, â€”R4 and â€”OR1, each independently selected; C3 is substituted with one of &boxH;O or two of H, â€”X and â€”OR1, each independently selected; C5 is substituted with one of â€”X or R4; C6 and C7 are each substituted with one of H, â€”X or â€”OR1; each of C8, C9 and C14 is independently substituted with one of â€”X, â€”R4 or â€”OR1; C10 and C13 are each independently substituted with one of H or methyl: C17 is substituted with one hydrogen atom and one group selected from saturated C1-C30 hydrocarbyl groups and C1-C30 halogen substituted hydrocarbyl groups, excluding â€”CH(CH3)(CH2)3CH(CH3)2; the A, B, C and D rings are each fully saturated; each R1 is independently H or a protecting group such that â€”OR1 is a protected hydroxyl group, where vicinal â€”OR1 groups may together form a cyclic structure which protects vicinal hydroxyl groups, and where geminal â€”OR1 groups may together form a cyclic structure which protects a carbonyl group, with the proviso that either or both of â€”OR1 at C6 and C7 represents a carbonyl or protected carbonyl group; R4 at each occurrence is independently selected from H and C1-30 organic moiety that may optionally contain at least one heteroatom selected from the group consisting of boron, halogen, nitrogen, oxygen, silicon and sulfur, where two geminal R4 groups may together form a ring with the carbon atom to which they are both bonded; and X represents fluoride, chloride, bromide and iodide.