Patent ID: 6346539
Filing Date: 2002-02-12
Classification: A61K,A61P,A61Q

Abstract:
A method of treating a subject having a skin condition selected from the group of conditions (a) those treatable by stimulation of melanocyte proliferation and (b) melanomas, which comprises administering to the subject an effective amount of a compound of formula (1) wherein n=0, or 2; when n=0, R2 and R3 represent hydrogen atoms or together represent a carbon to carbon double bond; when n=1, or 2 R2 and R3 together and R4 and R5 together represent carbon to carbon double bonds, R2 and R3 together represent a carbon to carbon double bond and R4 and R5 represent hydrogen atoms, or R2, R3, R4 and R5 all represent hydrogen atoms; m=1, 2 or 3; when m=1, R1 represents an alkoxy group having from 1 to 3 carbon atoms or a hydroxy group; when m=2, each R1 independently represents an alkoxy group having from 1 to 3 carbon atoms or the two R1s together represent a 3â€²,4â€²-methylenedioxy group; when m=3, two R1s together represent a 3â€²,4â€²-methylenedioxy group and the other R1 represents an alkoxy group having from 1 to 3 carbon atoms or a hydroxy group; R6 represents a pyrrolidino, piperidino, 4-methylpiperidino or morpholino group, a N-monoalkylamino group of 4 to 6 carbon atoms, a N-monocycloalkylamino group of 4 to 7 carbon atoms, a 3â€²,4â€²-methylenedioxy-substituted benzylamino or 2-phenethylamino group or R6 represents an alkoxy group of 1 to 6 carbon atoms; in any of its E, Z geometrically isomeric forms.