Patent ID: 6780887
Filing Date: 2004-08-24
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I, a salt or a prodrug thereof corresponding to formula I: wherein: R1 is selected from the group consisting of CH2, NH, and a group wherein said group together with R3 and/or R4 forms an aromatic or non-aromatic ring having 5 or 6 carbon atoms, optionally comprising on each ring an heteroatom, preferably a nitrogen, oxygen or sulfur atom, R3 and/or R4 represent: an amine having the formula: or a group having the formula â€”Zâ€”R6 wherein: Z represents O or S, R5 represents H or an alkyl group with 1 to 6 carbon atoms, R6 represents a hydrophobic group, preferably a terbutyl, an allyl or an aromatic or non-aromatic ring having 5, 6 or 7 carbon atoms optionally comprising one or several heteroatoms and wherein the carbon atoms are optionally substituted for by: an alkyl group R7 having 1 to 6 carbon, a ketone group, a hydroxyl group, an ester group, a halogen element (F, Cl, Br or I), a trifluoromethyl group (CF3), or a group having the formula: wherein: W represents CH or a nitrogen atom, Y represents S or O, and R8 represents an alkyl group having 1 to 6 carbon atoms, preferably a methyl or ethyl group, with the additional condition that, if R3 together with R1 forms said above-mentioned ring or if R3 is either an amine of formula: or the above-mentioned group of formula â€”Zâ€”R6, R4 represents an alkyl group having 1 to 10 carbon atoms, either saturated or unsaturated, optionally comprising one or more heteroatoms.