Patent ID: 7892414
Filing Date: 2011-02-22
Classification: C12Q,G01N,Y10S

Abstract:
1. A biosensor comprising: a) an electrode; b) a non-conductive polymer deposited on the electrode to form a matrix material having a plurality of pores therethrough; c) a capture biomolecule immobilized on the matrix material capable of binding a target analyte in a sample to be analyzed; wherein the binding of the target analyte to the capture biomolecule effectively blocks a sufficient number of pores in the matrix material to produce a measurable decrease in the rate of a redox reaction occurring at the electrode; d) a current source, wherein the current source provides a flow of electrons to drive a redox reaction at the electrode between the electrode and a redox species in contact with the electrode; and e) a detector element coupled to the electrode to detect the measureable decrease a change in the rate of a redox reaction occurring at the electrode due to the number of pores in the matrix material blocked by the binding of the target analyte.