Patent ID: 6673809
Filing Date: 2004-01-06
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I: where:A is or Y is â€”Eâ€”C(O)R1 or â€”Eâ€”NR2R3; E is a bond or â€”CH2â€”; R1 is independently at each occurrence hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, optionally substituted heterocycle, or NR2R4; R2 is independently at each occurrence hydrogen, C1-C6 alkyl, (C1-C6 alkyl)-aryl, or aryl; R3 is independently at each occurrence hydrogen, C1-C6 alkyl, C1-C4 alkoxy, optionally substituted heterocycle, optionally substituted C3-C8 cycloalkyl, optionally substituted C6-C10 bicycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, optionally substituted (C1-C4 alkyl)-heterocycle, C(O)C(O)R9, C(O)R5, or R2 and R3, together with the nitrogen to which they are attached, combine to form an optionally substituted N-heterocycle; R4 is independently at each occurrence hydrogen, C1-C6 alkyl, C1-C4 alkoxy, optionally substituted C3-C8 cycloalkyl, optionally substituted C6-C10 bicycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, optionally substituted (C1-C4 alkyl)-heterocycle, optionally substituted heterocycle, or R2 and R4, together with the nitrogen to which they are attached, combine to form an optionally substituted N-heterocycle; R5 is independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, (C1-C4 alkoxy)-aryl, (C1-C4 alkoxy)-heterocycle, (C1-C4 alkoxy)â€”SiCH3, optionally substituted (C1-C4 alkyl)-(C3-C8 cycloalkyl), optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, diphenylmethyl, optionally substituted (C1-C4 alkyl)â€”CO-aryl, optionally substituted (C1-C4 alkyl)-heterocycle, optionally substituted heterocycle, optionally substituted (C1-C4 alkyl)-phenoxy, (CH2)tC(R6)(R7)N(R6)(R8), or NR2R4; t is 0, 1, 2, 3, or 4; R6 is independently at each occurrence hydrogen or C1-C6 alkyl; R7 is independently at each occurrence hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, or optionally substituted heterocycle; R8 is independently at each occurrence hydrogen, C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C6-C10 bicycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, optionally substituted (C1-C4 alkyl)-heterocycle, optionally substituted heterocycle, C(O)OR9, C(O)R10, or R6 and R8, together with the nitrogen to which they are attached, combine to form an optionally substituted N-heterocycle; R9 is independently at each occurrence hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, or optionally substituted heterocycle; R10 is independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, (C1-C4 alkoxy)-aryl, (C1-C4 alkoxy)-heterocycle, (C1-C4 alkoxy)â€”SiCH3, optionally substituted (C1-C4 alkyl)-(C3-C8 cycloalkyl), optionally substituted (C1-C4 alkyl)-aryl, optionally substituted aryl, diphenylmethyl, optionally substituted (C1-C4 alkyl)â€”CO-aryl, optionally substituted (C1-C4 alkyl)-heterocycle, optionally substituted heterocycle, or optionally substituted (C1-C4 alkyl)-phenoxy; or a pharmaceutical salt thereof;wherein: optionally substituted alkyl refers to a C1-C4 alkyl unsubstituted or substituted from 1 to 3 times with halo, C1-C4 alkanol, NH2, or hydroxy; optionally substituted (C1-C4 alkyl)-aryl refers to an optionally substituted aryl linked through an optionally substituted C1-C4 alkyl; optionally substituted (C1-C4 alkyl)â€”CO-aryl refers to an optionally substituted aryl linked through a carbonyl and an optionally substituted C1-C4 alkyl, optionally substituted (C1-C4 alkyl)-heterocycle refers to optionally substituted heterocycle linked through an optionally substituted C1-C4 alkyl, optionally substituted (C1-C4 alkyl)-phenoxy refers to an unsubstituted or substituted phenoxy linked through an optionally substituted C1-C4 alkyl; optionally substituted aryl refers to an aryl group optionally substituted from 1 to 5 times independently with C1-C6 alkyl, halo, hydroxy, trifluoromethyl, C1-C6 alkoxy, benzyloxy, or trifluoromethoxy; optionally substituted C6-C10 bicycloalkyl refers to a C6-C10 bicycloalkyl group optionally substituted from 1 to 5 times independently with C1-C6 alkyl, halo, hydroxy, trifluoromethyl, C1-C6 alkoxy, benzyloxy, or trifluoromethoxy; optionally substituted C3-C8 cycloalkyl refers to a C3-C8 cycloalkyl optionally substituted once with a phenyl, substituted phenyl, hydroxy, or C1-C4 alkoxy; optionally substituted heterocycle refers to a heterocycle ring optionally substituted 1 or 2 times independently with a C1-C6 alkyl, halo, benzyl, phenyl, trifluoromethyl, or an oxo group; heterocycle refers to stable aromatic and non-aromatic 5- and 6-membered rings containing from 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, said rings being optionally benzofused; N-heterocycle refers to a nitrogen containing heterocycle linked through a nitrogen atom; optionally substituted N-heterocycle refers to a heterocycle ring, linked through the nitrogen atom, optionally substituted 1 or 2 times independently with a C1-C6 alkyl, halo, benzyl, phenyl, trifluoromethyl, or an oxo group; substituted phenoxy refers to a phenoxy group wherein the phenyl is optionally substituted from 1 to 5 times independently with C1-C6 alkyl, halo, hydroxy, trifluoromethyl, C1-C6 alkoxy, benzyloxy, or trifluoromethoxy; and substituted phenyl refers to a phenyl group substituted from 1 to 5 times independently with C1-C6 alkyl, halo, hydroxy, trifluoromethyl, C1-C6 alkoxy, benzyloxy, or trifluoromethoxy.