Patent ID: 6562367
Filing Date: 2003-05-13
Classification: A61F,A61K,A61P

Abstract:
A transdermal therapeutic system for transcutaneous administration of sex steroids over a period of up to seven days having an attachment aid for the system onto skin, wherein the system comprises a layer-form of a sex steroid-containing matrix mass disposed on a carrier film, and said matrix mass comprising a solid solution of (a) a copolymer of ethyl acrylate and methyl methacrylate containing about 5% trimethylammonium ethyl methacrylate chloride as the sole (meth)acrylate copolymer, (b) about 25 weight percent to about 30.5 weight percent of at least one plasticizer, (c) an optional ethylene acrylate terpolymer, and (d) at least 2 weight percent of each sex steroid distributed in a molecularly dispersed form in the matrix mass, said sex steroid selected from the group consisting of an androgen, an estrogen, a gestagen, and a mixture of an estrogen and a gestagen, and surrounded by a larger active-ingredient-free plaster for attachment to an application site, with the exception of a release surface on the skin, wherein at least one sex steroid underwent a minimum thermal exposure, and wherein the system is free of a rate-controlling polymer layer for delivery of the sex steroids.