Patent ID: 9029390
Filing Date: 2015-05-12
Classification: A61K,A61P

Abstract:
1. An oral, non-hemolytic, oily liquid, pharmaceutical formulation comprising the oily liquid, free base form of clopidogrel, as an antiplatelet agent, dissolved in at least one hydrophilic non-ionic surfactant selected from the group consisting of macrogolglycerol ricinoleate, macrogolglycerol hydroxystearate, macrogol 15 hydroxystearate, and a mixture of macrogolglycerol hydroxystearate and vitamin E/polyethylene glycol succinate, said formulation having a pH close to neutrality after dilution in water, lacking of food effect and without gastric irritation, and the solubility of the clopidogrel in the formulation is greater than 70 mg/ml in a simulated intestinal fluid according to the pharmacopeia USP XXI at pH 7.5 and at 37° C.