Patent ID: 9205142
Filing Date: 2015-12-08
Classification: A61K,A61P,C07K

Abstract:
1. An immunogenic composition comprising a combination of antigens, said combination comprising (1) a detoxified mutant hla antigen comprising (a) a first sequence having 90% or more identity to SEQ ID NO: 218; and (b) a second sequence having 90% or more identity to SEQ ID NO: 219, wherein the detoxified mutant hla comprises a detoxifying mutation selected from the group consisting of (i) mutation of the amino acid corresponding to residue 35 in SEQ ID NO: 218, (ii) mutation of the amino acid corresponding to residue 101 in SEQ ID NO: 218, (iii) mutation of the amino acid corresponding to residue 4 in SEQ ID NO: 219, and (iv) combinations of the foregoing, and (2) one or more antigens selected from the group consisting of: an esxA antigen; an esxB antigen; an sta006 antigen; an sta011 antigen; a LukE antigen; and an spa antigen.