Patent ID: 8778900
Filing Date: 2014-07-15
Classification: C07H,C12N,C12Q

Abstract:
1. A compound comprising a modified oligonucleotide consisting of 13 to 50 linked nucleosides and having at least an 8 contiguous nucleobase portion of a nucleobase sequence which is complementary to nucleotides 423-457, nucleotides 459-495, nucleotides 484-544, nucleotides 550-569, nucleotides 587-637, nucleotides 666-728, nucleotides 742-761 or nucleotides 767-786 of SEQ ID NO:4 encoding eIF4E-BP1, wherein the modified oligonucleotide comprises: a gap segment consisting of linked deoxynucleosides; a 5′ wing segment consisting of linked nucleosides; a 3′ wing segment consisting of linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment and wherein each of said nucleosides of each of said wing segments comprises a modified sugar.