Patent ID: 6136560
Filing Date: 2000-10-24
Classification: A61K,C12N

Abstract:
An isolated polynucleotide comprising a first polynucleotide or the full complement of the entire length of the first polynucleotide, wherein the first polynucleotide is identical to SEQ ID NO:1, except that, over the entire length corresponding to SEQ ID NO:1, n.sub.n nucleotides are substituted, inserted or deleted, wherein n.sub.n satisfies the following expressionn.sub.n .ltoreq.x.sub.n -(x.sub.n .multidot.y)wherein x.sub.n is the total number of nucleotides in SEQ ID NO:1, y is at least 0.99, and wherein any non-integer product of x.sub.n and y is rounded down to the nearest integer before subtracting the product from x.sub.n.