Patent ID: 6531481
Filing Date: 2003-03-11
Classification: C07D

Abstract:
A 4&bgr;-methyl or a 9&bgr;-methyl compound represented by formula (III): whereR1 is an alkyl group or an aralkyl group; R2 is hydrogen, an alkyl group, an aralkyl group, &boxH;O, â€”NH2, â€”NHR, â€”N(R)2, â€”NHC(O)R, â€”NRC(O)R, â€”NHC(O)R5, or â€”NRC(O)R5; R3 and R4 may be hydrogen or methyl, with the proviso that when R3 is methyl then R4is hydrogen and when R3 is hydrogen then R4is methyl; each R is, independently, an alkyl group, an aryl group, or an aralkyl group; and R5 is each X is, independently, halogen, â€”OH, â€”OR, an alkyl group, an aryl group, â€”NH2, â€”NHR, â€”N(R)2, â€”CF3, â€”CN, â€”C(O)NH2, â€”C(O)NHR, or â€”C(O)N(R)2; each R is, independently, as defined above; n is 0 or an integer from 1 to 5; and Ra is hydrogen or an alkyl group, or a pharmaceutically acceptable salt thereof.