Patent ID: 8354403
Filing Date: 2013-01-15
Classification: A61P,C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof: wherein: m is 0, 1, 2, 3, 4, or 5; n is 0, 1, 2, 3, 4, or 5; p is 0, 1, or 2; q is 0, 1, 2, 3, or 4; Ar is phenyl or pyridyl; Y is a ring system selected from the group consisting of: Z is selected from the group consisting of: each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R wherein R d and R e are each hydrogen or C 1 -C 6 alkyl; or two R d groups or two R e groups together with the carbon atom to which they are attached form a 3- to 6-membered ring containing 0 or 1 hetero atom selected from oxygen and nitrogen; and wherein the 3- to 6-membered ring is optionally substituted with 1 to 5 R 3 groups; wherein R f and R g are each hydrogen or C 1 -C 6 alkyl; or R f and R g form a C 1 -C 4 alkylene bridge; wherein R h and R i are each hydrogen or C 1 -C 6 alkyl; or R h and R i form a C 1 -C 4 alkylene bridge; and