Patent ID: 8461345
Filing Date: 2013-06-11
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of Formula 1 comprising coupling a compound of Formula 2 with a compound of Formula 3 in the presence of a polar aprotic solvent; to produce a compound of Formula 4 treating the compound of Formula 4 with an aqueous solution of about 7M sulfuric acid; stirring the mixture at a temperature of about 95-105° C. to obtain the compound of Formula 5 treating the compound of Formula 5 with triphosgene and diisopropylethylamine in the presence of tetrahydrofuran; stirring the solution until the reaction is complete; and treating the solution with anhydrous ammonia to obtain the compound of Formula 1; wherein each R each R′ is independently selected from hydrogen, C each R each X is Cl; and each Z is independently selected from C