Patent ID: 7122572
Filing Date: 2006-10-17
Classification: A61P,B01J,C07D,C07F,G01N,G21F

Abstract:
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a calix[4]pyrrole macrocycle consisting of structure I: that has 4 pyrrole rings linked in a positions via sp 3 hybridized meso-carbon atoms, wherein neither non-pyrrole substituent of the meso-carbon atoms is hydrogen, at least one pyrrole ring comprises a non-hydrogen β-substituent and the macrocycle is noncovalently-complexed to a halide anion; wherein R 1 –R 16 are independently substituents as listed in paragraph i) below, and R A –R D are independently substituents as listed in paragraph ii) below; i) hydrogen, halide, hydroxyl, alkyl, alkenyl or alkynyl; ii) hydrogen or alkyl; wherein odd-numbered R substituents are other than hydrogen and at least one even-numbered R substituent is other than hydrogen.