Patent ID: 7094534
Filing Date: 2006-08-22
Classification: C12Q,G06F,Y10S

Abstract:
1. A method of detecting an amplification or gain of unique sequences at at least one chromosomal region selected from the group consisting of: on human chromosome 1, on human chromosome 2, on human chromosome 3, on human chromosome 4, on human chromosome 5, on human chromosome 6, on human chromosome 7, on human chromosome 8, on human chromosome 10, on chromosome 11, on human chromosome 12, on human chromosome 13, on human chromosome 14, on human chromosome 15, entire human chromosome 16; on human chromosome 16, on human chromosome 17, on human chromosome 18, on human chromosome 19, entire human chromosome 20; on human chromosome 20, entire chromosome 21; entire chromosome 22; on the human X chromosome, (a) labelling nucleic acids from the test sample and from a control sample with different labels; (b) contacting said labelled nucleic acids from each sample with a plurality of target nucleic acids, wherein either the labelled nucleic acids or the target nucleic acids, or both, have had repetitive sequences, if initially present, blocked and/or removed; and (c) comparing the intensities of the signals from labelled nucleic acids hybridized to each target nucleic acid, thereby allowing detection of the presence or absence of the gain or amplification in the test sample.