Patent ID: 7981916
Filing Date: 2011-07-19
Classification: A61K,A61P

Abstract:
1. An aqueous solution of metronidazole, the aqueous solution comprising an intimate admixture of metronidazole with niacinamide or salt thereof and at least two glycolic cosolvents and devoid of cyclodextrin, wherein the aqueous solution is prepared by solubilizing the metronidazole with the niacinamide or salt thereof and the at least two glycolic cosolvents by intimate admixing in the absence of cyclodextrin, wherein the aqueous solution comprises: 1) metronidazole in a proportion of greater than or equal to 1%, 2) niacinamide in a proportion such that the niacinamide/metronidazole molar ratio is less than 9, and 3) propylene glycol and at least one polyethylene glycol, as the at least two glycolic cosolvents.