Patent ID: 8884060
Filing Date: 2014-11-11
Classification: A01N,A61K,A61P,C07B,C07C,C07D,C12N

Abstract:
1. A process for preparing a compound of Formula IV: wherein: A is optionally substituted aryl or optionally substituted heteroaryl; B is 3,5-di-methylphenyl; R R wherein the asymmetric carbon atom to which R comprising: a) reacting a compound of Formula V: with a compound of Formula VI: wherein: X and Y are independently O or NR wherein R is alkyl or aryl; C R R R R R to form a compound of Formula VII: b) reducing the compound of Formula VII to form a compound of Formula VIII: c) reacting the compound of Formula VIII with a compound of Formula B-CO-LG wherein B is 3,5-di-methylphenyl and LG is a leaving group to form a compound of Formula IX: d) removing the R e) reacting the compound of Formula X with a compound of Formula A-CO-LG wherein A is optionally substituted aryl or optionally substituted heteroaryl and LG is a leaving group, to form a compound of Formula IV selected from the group consisting of: (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N′-benzoyl-N-(1-tert-butyl-butyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-fluoro-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(2-bromo-benzoyl)-N-(1-tert-butyl-butyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(3-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(4-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-chloro-pyridine-3-carbonyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(6-chloro-pyridine-3-carbonyl)-hydrazide; and (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(3-methoxy-2-methyl-benzoyl)-hydrazide.