Patent ID: 6114535
Filing Date: 2000-09-05
Classification: C07D,Y02P

Abstract:
A process for the manufacture of a compound of formula V ##STR31## wherein R.sub.4 and R.sub.6 are each independently H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl or substituted phenyl; andR.sub.5 is H; halogen; C.sub.1 -C.sub.6 alkyl optionally substituted with one or more C.sub.1 -C.sub.4 alkoxy groups; C.sub.1 -C.sub.6 alkenyl; phenyl or substituted phenylwhich comprises:reacting a compound of formula II or the alkali metal salt thereof ##STR32## wherein X is O or S; R.sub.1 is C.sub.1 -C.sub.6 alkyl, phenyl or substituted phenyl; and R.sub.2 and R.sub.3 are each independently C.sub.1 -C.sub.6 alkyl, phenyl or substituted phenyl with at least one molar equivalent of a compound of formula III ##STR33## wherein R.sub.4, R.sub.5 and R.sub.6 are as described for formula V and an ammonia source in the presence of a solvent optionally at an elevated temperature to give a compound of formula I ##STR34## wherein R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are described hereinabove; reacting said formula I compound with an amino amide of formula VI ##STR35## in the presence of an inert solvent and a strong base to give the carboxylate salt of the desired formula V compound;and acidifying said carboxylate salt to give the desired free carboxylic acid compound of formula V.