Patent ID: 6720322
Filing Date: 2004-04-13
Classification: C07D

Abstract:
A compound of the formula I: whereinR1 represents phenyl; mono-, di- or tri-substituted phenyl substituted with halogen, lower alkyl, lower alkenyl, lower alkenyl, lower alkoxy, hydroxy-lower alkyl, hydroxy-lower alkenyl, hydroxy-lower alkynl, trifluoromethyl, cycloalkyl, or hydroxy-cycloalkyl; 2-pyridyl; 5-substituted 2-pyridyl substituted with lower alkyl; or a five-membered heteroaryl ring containing one or two nitrogen, sulfur or oxygen atoms; R1 represents hydrogen; lower alkyl; phenyl; mono-, di- or tri-substituted phenyl substituted with halogen, lower alkyl, lower alkoxy, lower alkyloxy-lower alkyl, or trifluoromethyl; or a five-membered heteroaryl ring contatining one or two nitrogen, sulfur or oxygen atoms and which may be mono- or di-substituted with halogen, lower alkyl, lower alkoxy, or tirfluoromethyl, 2-pyrimidyl; mono- or di-substituted 2-pyrimidyl substituted with lower alkyl, lower alkoxy, halogen, or trifluoromethyl; or a group of the formula, â€”C(A)â€”Bâ€”Ra, wherein A represents O or S; B represents NH; and Ra represents lower alkyl; cycloalkyl; phenyl; mono-, di- or tri-substituted phenyl substituted with halogen, lower alkyl, lower alkenyl, lower alkoxy, or trifluoromethyl; or a six-membered heteroaryl ring containing one or two nitrogen atoms and which may be mono- or di-substituted with halogen, lower alkyl, or lower alkyloxy; R3 represents phenyl; mono-, di- or tri-substituted with lower alkyl, lower alkenyl, lower alkyloxy, trifluoromethyl, halogen, or hydroxy; R4 represents hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkyloxy, lower alkylthio, lower alkyloxy-lower alkyl; phenyl; mono- or di-substituted phenyl substituted with halogen, lower alkyl, lower alkoxy, lower alkylene or lower alkenylene or lower alkylenoxy or lower alklenedioxy forming with the phenyl ring a five- or six-membered ring; heteroaryl; or heterocyclyl; and X represents oxygen; sulfur; or a bond; and pure enantiomers, enantiomerically pure diastereomers, mixtures of diastereomers, diastereomeric recemates, mixtures of diastereomeric racemates and pharmaceutically acceptable salts thereof.