Patent ID: 9145557
Filing Date: 2015-09-29
Classification: C07H,C12N

Abstract:
1. A steric block oligonucleotide incapable of recruiting RNase H and RNAi machinery, wherein the oligonucleotide comprises units selected from the group consisting of 2′-O-fluoro units, 2′-O-methoxyethyl, LNA (locked nucleic acid) units, PNA (peptide nucleic acid) units, phosphoramidate units, INA (intercalating nucleic acid), morpholino units, 2′-deoxy-2′-fluoro-arabinonucleic acid (FANA) units, and arabinonucleic acid (ANA) units, and wherein the oligonucleotide comprises a contiguous sequence complementary to at least 12 contiguous bases of SEQ ID NO: 1.