Patent ID: 8367653
Filing Date: 2013-02-05
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) wherein i) substituted C ii) C iii) trifluoromethyl; or iv) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, isoxazolyl, imidazolyl, furazan-3-yl, benzothienyl, thieno[3,2-b]thiophen-2-yl, pyrazolyl, triazolyl, tetrazolyl, and [1,2,3]thiadiazolyl; i) C ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, indazolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, imidazo[1,2-a]pyridin-2-yl, quinolinyl, thienyl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1H-thieno[2,3-c]pyrazol-5-yl, and benzimidazolyl; iii) 7-(4-chloro-benzylidene)-1-(2,4-dichloro-phenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yl; iv) 2-oxo-3,3-bis-(3-trifluoromethylphenylmethyl)-2,3-dihydro-1H-indol-5-yl; v) 5-[2-(4-chloro-phenyl)-1-methyl-vinyl]-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl; vi) 1-(2,4-dichloro-phenyl)-7-(4-fluoro-benzylidene)-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazol-3-yl; vii) 2,3-dihydro-1H-indolyl; viii) 7-(4-chloro-benzylidene)-1-(2,4-dichloro-phenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yl; ix) 4-{1-[1-(2,4-dichloro-phenyl)-7-(4-fluoro-benzylidene)-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazol-3-yl; x) 1,1,3-tris-(3-trifluoromethylphenylmethyl)indan-2-on-6-yl; or xi) 1,1,3-tris-(phenylmethyl)indan-2-on-6-yl, and s is 0; i) C ii) C iii) 3-trifluoromethyl-phenylaminocarbonylmethoxy; iv) C v) phenyl(C vi) phenylcarbonyl optionally substituted with chloro or fluoro; vii) 2,3-dihydro-1H-indol-5-ylcarbonyl; viii) N-methyl-N-phenyl-aminocarbonyl-methyl; ix) pyrrolidin-1-ylcarbonylmethyl; x) phenyl(C xi) heteroaryl(C xii) heteroaryl(C xiii) heteroaryl(C xiv) heteroaryl-(Q)-C xv) phenyl-(Q)-C and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.