Patent ID: 8389546
Filing Date: 2013-03-05
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating a condition involving activation of TRPV3 or for which reduced TRPV3 activity can reduce the severity, comprising administering to a subject in need thereof an effective amount of a compound of Formula I or a salt thereof: wherein: R X represents S or O; n represents 1 or 2 when X is O, or n represents 1 when X is S; m represents 0, 1, 2, 3, or 4; R said compound inhibits TRPV3 with an IC the condition is selected from the group consisting of acute or chronic pain, touch sensitivity, burns, inflammation, diabetic neuropathy, psoriasis, post-herpetic neuralgia (shingles), migraine, incontinence, fever, hot flashes, osteoarthritis, rheumatoid arthritis, and cough.