Patent ID: 7105559
Filing Date: 2006-09-12
Classification: A61P,C07C,C07D

Abstract:
1. A compound having the formula wherein X is pyrazolinone, pyrazole-n-oxide, n-hydroxypyrrolidine, or cyclopentadienone; Z Z wherein R 304 and R 306 are independently selected from the group consisting of hydrogen, fluorine, hydroxy, carboxy, hydrocarbyloxy, and alkoxycarbonyl and R 305 and R 307 are independently selected from the group consisting of hydrogen, fluorine, methoxy, hydroxy, and carboxy; and Z wherein R 42 is amino; R 44 is selected from the group consisting of hydroxy, isobutylsulfonyl, trifluoromethyl, carboxamidobenzyl, carboxamidobutyl-2-yl, isobutyramido, isobutoxy, carboethoxy, carboxyl, amino, 3-aminomethylthiophene, benzylamine, phenethylamine, isobutylamine, methoxyethylamide, 1-carboxylbenzylamide, p-fluorobenzylamide, cyclobutylamide, m-fluorobenzylamide, 1-methylbenzylamide, sec-butylamide, benzylacylamine, isobutylamide, sec-pentylamine, cyclopentylacylamine, 1-carboxyl-2-methylbutylamide, isobutylacylamine, isobutylsulfoxyl, 2-cyclohexylamide, methoxy, sulfonamide, isobutylsulfonamide, aminoacyltrifluoromethyl, and carbmethoxy; and R 41 , R 43 and R 45 are independently selected from the group consisting of hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, and an optionally substituted heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur.