Patent ID: 7732603
Filing Date: 2010-06-08
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein X is oxygen or H R R R R R in which each alkyl is optionally substituted with halo, hydroxy, cycloalkyl, alkanoyl, alkoxy, alkyloxyalkoxy, alkanoyloxy, amino, alkylamino, dialkylamino, acylamino, carbamoyl, thiol, alkylthio, alkylthiono, sulfonyl, sulfonamido, sulfamoyl, nitro, cyano, carboxy, alkoxycarbonyl, aryl, alkenyl, alkynyl, araloxy, guanidino and monocyclic heterocyclyl; and each aryl is optionally substituted with alkyl, trifluoromethyl, cycloalkyl, halo, hydroxy, alkoxy, acyl, alkanoyloxy, aryloxy, amino, thiol, alkylthio, arylthio, nitro, cyano, carboxy, alkoxycarbonyl, carbamoyl, alkylthiono, sulfonyl, sulfonamido and monocyclic heterocyclyl; and each cycloalkyl is optionally substituted with alkyl, halo, oxo, hydroxy, alkoxy, alkanoyl, acylamino, carbamoyl, alkylamino, dialkylamino, thiol, alkylthio, nitro, cyano, carboxy, alkoxycarbonyl, sulfonyl, sulfonamido, sulfamoyl and monocyclic heterocyclyl; and each heterocyclyl and heteroaryl are independently optionally substituted with alkyl, hydroxy, halo, oxo, amino, alkylamino, dialkylamino, alkoxy, cycloalkyl, carboxy, alkoxycarbonyl, mercapto, cyano, nitro, sulfamoyl, sulfonamido, aryl, alkanoyloxy, aroyloxy, arylthio, aryloxy, alkylthio, formyl, carbamoyl, aryl and arylalkyl; and each heteroaryl is selected from 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, 2-furyl or 3-furyl; and each heterocyclyl is selected from morpholinyl, 2-thienyl, 3-thienyl, piperidinyl, 2-furyl, 3-furyl, 2-pyridyl, 3-pyridyl or 4-pyridyl; or a pharmaceutically acceptable salt thereof; or a diastereomer thereof; or a mixture of diastereomers thereof; or an optical isomer thereof; or a mixture of optical isomers thereof.