Patent ID: 7470785
Filing Date: 2008-12-30
Classification: C07D

Abstract:
1. A method of making a tetrahydrobilene of Formula XI: wherein: K K S and wherein from one to four of S wherein; n is from 0 to 10; R R Y is a protected or unprotected reactive substituent selected from the group consisting of hydroxy, thio, seleno, telluro, ester, carboxylic acid, boronic acid, phenol, silane, sulfonic acid, phosphonic acid, alkylthiol, formyl, halo, alkenyl, alkynyl, haloalkyl, alkyl phosphonate, alkyl sulfonate, alkyl carboxylate, and alkyl boronate groups; and Z is selected from the group consisting of halo, alkoxy, and acyloxy; said method comprising condensing a compound of Formula WH with a compound of Formula EH in an organic solvent in the presence of an acid to form a tetrahydrobilene of Formula XI.