Patent ID: 9011862
Filing Date: 2015-04-21
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody, or fragment thereof, that specifically binds to a region in an Aβ-peptide capable of being nitrated, wherein said antibody, or fragment thereof, is produced according to a method comprising the steps of a) affinity purification of a serum containing antibodies using a nitrated Aβ-peptide coupled to a chromatography column, or screening an sc-Fv phage display library using a nitrated Aβ-peptide, and b) optionally following step a) with a further purification step through exclusion of binding to a non-nitrated Aβ-peptide; wherein said antibody is a monoclonal, polyclonal, human, humanized, and/or recombinant antibody or a functional fragment thereof, and wherein said antibody specifically binds to an Aβ peptide that is nitrated at position 10 and does not bind to an Aβ peptide that is not nitrated at position 10.