Patent ID: 8153384
Filing Date: 2012-04-10
Classification: A61P,C12Q,G01N

Abstract:
1. A method for diagnosing ovarian cancer in a subject comprising: (a) obtaining a biological sample from a subject, wherein the biological sample is derived from ovarian tissue; (b) determining the level of expression of Microtubule Affinity Regulating Kinase 2 (MARK2) or Microtubule Affinity Regulating Kinase 3 (MARK3) in the biological sample of step (a), wherein the expression of MARK2 is determined by measuring the expression of SEQ ID NO: 1 or an encoded polypeptide thereof, and the expression of MARK3 is determined by measuring the expression of SEQ ID NO: 13 or an encoded polypeptide thereof; (c) comparing the level of expression of MARK2 or MARK3 in the biological sample of step (b) with the level of expression of MARK2 or MARK3, respectively, in a control sample; and (d) diagnosing ovarian cancer by detecting an elevated level of MARK2 or MARK3 expression in the biological sample compared with the control sample.