Patent ID: 6333328
Filing Date: 2001-12-25
Classification: A61K,A61P,C07D

Abstract:
A method for preparing a serotonin 5-HT.sub.3 receptor partial activator which comprisesmixing a compound represented by formula (2) with a pharmaceutically acceptable carrier, wherein formula (2) is: ##STR10##wherein R.sub.1 to R.sub.4 are the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R.sub.1 and R.sub.2 are linked together to form a benzene ring and R.sub.3 and R.sub.4 are hydrogen atoms, with the proviso that compounds in which all of R.sub.1 to R.sub.4 are hydrogen atoms are excluded; R.sub.5 represents a hydrogen atom; and m is an integer of 1 to 4, in which said lower alkyl group means a straight or branched C.sub.1 -C.sub.4 alkyl group, said lower alkenyl group means a straight or branched C.sub.2 -C.sub.4 alkenyl group, the substituent for said lower alkyl or lower alkenyl group is selected from the group consisting of a halogen atom, a hydroxyl group, a carbamoyl group, an amino group and a cyano group, the substituent for said amino group is selected from the group consisting of a straight or branched C.sub.1 -C.sub.4 alkyl group, a straight or branched C.sub.1 -C.sub.4 alkycarbonyl group, a straight or branched C.sub.2 -C.sub.4 alkenyl group and a benzylidene group which may have a phenyl group, and said halogen atom is selected from the group consisting of fluorine, chlorine, bromine and iodine atoms.