Patent ID: 8841335
Filing Date: 2014-09-23
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating a disease selected from the group consisting of stroke, Alzheimer's disease, Huntington's disease, Pick's disease, Creutzfeld-Jacob's disease, Parkinson-ALS-dementia complex, Wilson's disease, multiple sclerosis, progressive supranuclear palsy, neuropathic pain-related bipolar disorders, corticobasal degeneration, schizophrenia, attention deficit hyperactivity disorder (ADHD), dementia, amyotrophic lateral sclerosis, retinal disease, epilepsy, apoplexy, transient ischemic attacks, myocardial ischemia, muscle ischemia, ischemia caused by surgical technique regarding extended suspension of blood flow to brain, head injury, spinal cord injury, hypoxia and depression, comprising: administering to a subject in need of such treatment a therapeutically effective amount of a compound of Formula I, a pharmaceutically acceptable salt, an isomer, a solvate, or a hydrate thereof, or any combination thereof: wherein R is selected from the group consisting of substituted or unsubstituted C Y is selected from the group consisting of O and —N—R R R A is selected from the group consisting of N, O, and S; B is C or N; Z is selected from the group consisting of carbamate, —OC(═O)NR each of R each of R each of R m is an integer in the range of 0 to 4; and n is an integer in the range of 0 to 5.