Patent ID: 8063039
Filing Date: 2011-11-22
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating pain, migraine, inflammation, gastrointestinal tract disorders, disorders of the genito-urinary tract, ophthalmic diseases or obesity in a subject, said method comprising administering to said subject an effective amount of a compound of general formula I and the pharmaceutically acceptable salts thereof, wherein m is an integer from 1 to 3; X is methylene, oxygen, sulphur or a NR R 3-(4-Benzyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; rings optionally substituted by one or more C 1 -C 4 alkyl, halogens, trifluoromethyl, hydroxy or C 1 -C 4 alkoxy groups; R R