Patent ID: 7655429
Filing Date: 2010-02-02
Classification: C07H,G01N,Y10S

Abstract:
1. A method of performing an immunodiagnostic assay for detecting the presence of topiramate in a sample obtained from a subject previously administered topiramate, the method comprising: combining an anti-topiramate antibody raised against an antigen and a topiramate analog with the sample to form a first composition, the anti-topiramate antibody including at least one binding domain having affinity, specificity or avidity for the topiramate analog and for topiramate, wherein the binding between the antibody and the topiramate analog is at least 50% of at least one of the affinity, the specificity or the avidity of the antibody for topiramate, said anti-topiramate antibody binding with topiramate and the topiramate analog; allowing any free topiramate from the sample and the topiramate analog to compete for binding with the antibody; detecting binding between the topiramate analog and the antibody; and the topiramate analog and the antigen having a chemical structure of Formula 1; where L is NH(CH X is at least one of the group CH Y is a chemical moiety selected from the group consisting of COOH, COO—NHS, COO-tertbutyl, and OH; or Y is a Y