Patent ID: 8173163
Filing Date: 2012-05-08
Classification: A61K,A61P

Abstract:
1. A degradable polymeric drug delivery composition comprising a water-insoluble drug blended with a copolymer comprising from 3 mol to 12 mol % biocompatible tyrosine-derived diphenol compound monomer units with pendant carboxylic acid groups polymerized with from 79 mol % to 91 mol % biocompatible tyrosine-derived diphenol compound monomer units with pendant carboxylic acid ester groups, and from 6 mol % to 18 mol % poly(alkylene oxide) blocks, wherein a molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and polyalkylene oxide blocks relative to a weight percentage of the water-insoluble drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during a sustained-release phase of drug delivery under physiological conditions.