Patent ID: 6290990
Filing Date: 2001-09-18
Classification: A61K

Abstract:
Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range of from 0.5 to 4 mm, said pellets comprisinga) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of ethylcellulose,c) 5-45% by weight of at least one water insoluble lipophilic compound as plasticizer for polymer b) and lubricant, selected from the group consisting of mono-, di- triglycerides or mixtures thereof and polyglycerol fatty acid esters,D) 3-40% by weight of a water soluble cellulose derivative as a gel-forming polymer which breaks up the release-slowing matrix by swelling of the ethylcellulose, said pellets being obtained by extrusion of a solvent-free molten mixture of the components at a temperature of from 50 to 200.degree. C. and continuous shaping.