Patent ID: 7737269
Filing Date: 2010-06-15
Classification: A61K,A61P,B82Y

Abstract:
1. A process for the preparation of a cyclodextrin/alpha-lipoic acid complex, comprising, in a first step, dissolving alpha-lipoic acid and a cyclodextrin in an aqueous alkaline solution having a pH above pH 7, and in a second step adding an acid to lower the pH of the solution to a pH below pH 7, wherein the pH of the aqueous solution during the first step is between pH 10 and pH 14, wherein the aqueous mixture in the first step has a solids content between 10 and 50% by weight based on the total weight of the aqueous mixture, wherein the molar ratio of cyclodextrin to alpha-lipoic acid is between 2.0 and 1.0, wherein the final pH of the aqueous solution in the second step is between pH 6 and pH 3, and wherein the cyclodextrin is an alpha cyclodextrin.