Patent ID: 6444234
Filing Date: 2002-09-03
Classification: A61K,A61P,Y10S

Abstract:
A liquid carrier composition effective for the transdermal delivery of a medicament having a given polarity, said formulation comprising(a) at least one non-aqueous non-toxic solvent selected from the group consisting of lower aliphatic mono- and poly-hydroxy compounds; (b) limonene, lemon oil or mixture of limonene and lemon oil; (c) methylsulfonylmethane; (d) a skin stabilizer which comprises at least one compound selected from the group consisting of an aliphatic carboxylic acid having from 8 to 32 carbon atoms, an ester of said aliphatic carboxylic acid with an aliphatic alcohol having from 1 to 20 carbon atoms, wherein said ester has a total of from 9 to 36 carbon atoms; and Vitamin D3; (e) a solute modifier which comprises a compound selected from the group consisting of 3,3â€²-thiodipropionic acid, an ester thereof, and a salt thereof; an oxindole alkaloid, a polyphenolic flavonoid, a sugar adduct of a gluconuide, isoflavones, phosphatidyl serine, phosphatidyl choline, Vitamin D3 and Vitamin K1; and (f) adenosine triphosphate (ATP) or a compound which induces generation of cyclic adenosine 3â€²5â€²monophosphate cAMP in situ or cyclic quanosina monophosphate (cGMP) in situ.