Patent ID: 7105564
Filing Date: 2006-09-12
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound selected from the group consisting of: 7-(3-{[5-(Pyrrole-1-sulfonyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-1b), 7-(3-{[5-(Thiophene-2-sulfonyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-47), 7-(3-{[5-(Thiophen-2-ylsulfanyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-59), 7-(3-{[5-(Thiophen-3-ylsulfanyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-79), 7-(3-{[5-(Thiophene-3-sulfonyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-80), 7-(3-{[5-(5-Methyl-thiophene-2-sulfonyl)-thiophene-2carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-82), 7-(3-{[5-(Thiophen-3-ylmethyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-88), 7-(3-{[5-(Thiophen-2-ylmethyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-93), 7-(3-{[1-(Thiophene-2-sulfonyl)-1H-pyrrole-3-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-94), 7-(3-{[5-(Thiophen-2-ylsulfanylmethyl)-thiophene-2-carbonyl]amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-104), 7-(3-{[5-(Thiophen-2-ylmethylsulfanyl)-thiophen-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-106), 7-(3-{[5-(5-Methyl-thiophen-2-ylmethyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-129), 7-(3-{[5-(Benzofuran-2-ylmethyl)-thiophene-2-carbonyl]-amino}bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-136), 7-(3-{[7-(Thiophen-2-ylmethyl)-benzo[b]thiophene-3-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-168), 7-(3-{[7-(Thiophen-3-ylmethyl)-benzo[b]thiophene-3-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-169), 7-(3-{[7-(Furan-3-ylmethyl)-benzo[b]thiophene-3-carbonyl]amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (1–170), 7-(3-{[5-(Benzo[b]thiophen-3-ylmethyl)-thiophene-2-carbonyl]-amino}-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid (I-182), 7-(6,6-Dimethyl-2-{[5-(pyrrole-1-sulfonyl)-thiophene-2-carbonyl]-amino}-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid (II-15), 7-(6,6-Dimethyl-2-{[5-(thiophene-2-sulfonyl)-thiophene-2-carbonyl]-amino}-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid (II-18), 7-(6,6-Dimethyl-2-{[5-(thiophen-2-ylsulfanyl)-thiophene-2-carbonyl]-amino}-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid (II-21), 7-(6,6-Dimethyl-2-([5-(5-methyl-thiophene-3-sulfonyl)-thiophene-2-carbonyl]-amino)-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid (II-30), and 7-(6,6-Dimethyl-2-([5-(2-methyl-pyrrole-1-sulfonyl)-thiophene-2-carbonyl]-amino)-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid (II-34), or a pharmaceutically acceptable salt, or a hydrate thereof.