Patent ID: 6201140
Filing Date: 2001-03-13
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR34##wherein R.sup.1 is hydrogen, C.sub.1-8 alkyloxy, C.sub.2-8 alkenyloxy, or C.sub.2-8 alkynyloxy, each can be optionally substituted with hydroxy; R.sup.2 is hydroxy, --OC(O)R.sup.x or --OC(O)OR.sup.x ; R.sup.4 and R.sup.5 are independently C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, or --Z--R.sup.6 ; p is zero or one; Z is a direct bond, C.sub.1-8 alkylene or C.sub.2-8 alkenediyl; R.sup.6 is aryl, substituted aryl, C.sub.3-8 cycloalkyl or heteroaryl; and R.sup.x is C.sub.1-8 alkyl optionally, substituted with one to six same or different halogen atoms, C.sub.3-8 cycloalkyl or C.sub.2-8 alkenyl; or R.sup.x is a radical of the formula ##STR35##wherein D is a bond or C.sub.1-8 alkyl; and R.sup.a, R.sup.b and R.sup.c are independently hydrogen, amino, C.sub.1-8 alkylamino, di-C.sub.1-8 alkylamino, halogen, C.sub.1-8 alkyl, or C.sub.1-8 alkyloxy.