Patent ID: 7186804
Filing Date: 2007-03-06
Classification: A61P,C07K

Abstract:
1. A fusion protein comprising a non-IL-2 moiety fused to a mutant IL-2 moiety wherein the mutant IL-2 moiety comprises an amino acid substitution changing an aspartic acid to a threonine corresponding to position 20 of a mature human IL-2 protein consisting of the amino acid sequence set forth in SEQ ID NO:3, wherein the fusion protein exhibits greater selectivity than a reference protein towards cells expressing a high-affinity receptor, wherein said reference protein comprises the non-IL-2 moiety fused to a non-mutant IL-2 moiety, and wherein said selectivity is measured as a ratio of activation of cells expressing IL-2Rαβγ receptor relative to activation of cells expressing IL-2Rβγ receptor.