Patent ID: 7615528
Filing Date: 2009-11-10
Classification: A61K,A61P,C07H,G01N

Abstract:
1. A method for alleviating the deleterious effects of 3-deoxyglucosone (3DG) in a patient, said 3DG being produced by the enzymatic conversion of fructose-lysine to fructose-lysine-3-phosphate, said method comprising administering to said patient an inhibitor of said enzymatic conversion of fructose-lysine to fructose-lysine-3-phosphate said inhibitor being a compound having the formula: wherein X is a divalent moiety selected from the group consisting —NR′— or —O—, R′ being selected from the group consisting of H, and linear or branched chain alkyl group (C R is a substituent selected from the group consisting of H, an amino acid residue said amino acid including said NR′ moiety, a polyamino acid residue said polyamino acid including said NR′ moiety, a peptide chain, a linear or branched chain aliphatic group (C R Y is a hydroxymethylene moiety Z is selected from the group consisting of —H, —O-alkyl (C