Patent ID: 6638976
Filing Date: 2003-10-28
Classification: A61K,A61P

Abstract:
A method of treating or preventing a neurodegenerative disorder of the retina or optic nerve head in a patient suffering from or predisposed to such a disorder which comprises administering to the patient a therapeutically effective amount of 3-benzoylphenylacetic acid or derivative of the formula: wherein R=H, C1-4 (un)branched alkyl, CF3, SR4; Y=ORâ€², NRâ€³Râ€²; Râ€²=H, C1-10 (un)branched alkyl, aryl, aryl substituted by X, heterocycle, heterocycle substituted by X, â€”(CH2)nZ(CH2)n.A; n=2-6; nâ€²=1-6; Z=nothing, O, C&boxH;O, OC(&boxH;O), C(&boxH;O)O, C(&boxH;O)NR3, NR3C(&boxH;O), S(O)2, CHOR3, NR3; n2=0-2; R3=H, C1-6 (un)branched alkyl, aryl, aryl substituted by X, heterocycle, heterocycle substituted by X; A=H, OH, aryl, aryl substituted by X, heterocycle, heterocycle substituted by X, â€”(CH2)nOR3; Râ€³=H, OH, ORâ€²; X and Xâ€² independently=H, F, Cl, Br, I, ORâ€², CN, OH, S(O)n2R4, CF3, R4, NO2; R4=C1-6 (un)branched alkyl; m=0-3; mâ€²=0-5; and W=O, H.