Patent ID: 8921334
Filing Date: 2014-12-30
Classification: A61P,C12N,C12Q

Abstract:
1. A method of upregulating a function of and/or the expression of a Nuclear Respiratory Factor 1 (NRF 1) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of the NRF1 polynucleotide and is selected from a single stranded oligonucleotide or a double stranded siRNA oligonucleotide wherein a single strand thereof has at least 80% sequence identity to a reverse complement of said natural antisense polynucleotide of a Nuclear Respiratory Factor 1(NRF1) polynucleotide; thereby upregulating a function of and/or the expression of the Nuclear Respiratory Factor 1 (NRF1) polynucleotide in patient cells or tissues in vivo or in vitro.