Patent ID: 8048452
Filing Date: 2011-11-01
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer, at least 60 wt % of said cholesteryl ester transfer protein inhibitor being non-crystalline, wherein said cholesteryl ester transfer protein inhibitor has a Clog P greater than 4 and a solubility in aqueous solution in the absence of said concentration-enhancing polymer of less than 10 μg/ml at any pH of from 1 to 8, said solid amorphous dispersion comprises particles comprising both said cholesteryl ester transfer protein inhibitor and said concentration-enhancing polymer, and said solid amorphous dispersion has a glass transition temperature that is different than the glass transition temperature of the pure amorphous cholesteryl ester transfer protein inhibitor alone and different than the glass transition temperature of the pure concentration-enhancing polymer alone.