Patent ID: 6235736
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D

Abstract:
A 3-anilino-2-cycloalkenone derivative having the formula (I): ##STR125##wherein R.sub.1 represents a C.sub.3 to C.sub.8 alkyl group which may have a substituent, a C.sub.3 to C.sub.7 cycloalkyl group, a C.sub.6 to C.sub.10 bicycloalkyl group, a 3-tebrahydrofuryl group, or an indanyl group, R.sub.2 represents a C.sub.1 to C.sub.4 alkyl group, R.sub.3 respresents a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, which may have a substituent, a C.sub.3 to C.sub.7 cycloalkyl group, or an acyl group, R.sub.4 represents a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group which may have a substituent, a halogen atom, a group having the formula (II): ##STR126##wherein R.sub.9 and R.sub.10 independently represent a C.sub.1 to C.sub.5 alkyl group, or a group having the formula (III): ##STR127##wherein, m represents an integer of 2 to 6, provided that one CH.sub.2 group may be substituted with one hetero atom selected from the group consisting of oxygen, nitrogen, and sulfur, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 independently represent a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group which may have a substituent, or a phenyl group which may have a substituent, X represents (i) --(CR.sub.11 R.sub.12)n-- wherein R.sub.11, and R.sub.12 independently represent a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group which may have a substituent, or a phenyl group which may have a substituent, and n represents an integer of 0 or 2 or (ii) --NR.sub.13 -- wherein R.sub.13 represents a hydrogen atom or a C.sub.1 to C.sub.5 alkyl group which may have a substituent, provided that, when n is 0, X in the formula (I) is absent and the carbon atoms bonded to X in the formula (I) are bonded together to form a 5-membered ring, and its optical isomers or their pharmaceutically acceptable salts or their hydrates or solvates.