Patent ID: 6326501
Filing Date: 2001-12-04
Classification: C07D

Abstract:
A process for manufacturing a methylated indole compounds of the formula: ##STR29##where R.sup.1 is selected from the group consisting of halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, --OCH.sub.3, --NO.sub.2, --CHO, --CO.sub.2 CH.sub.3, and --CN, and R.sup.2 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, --CO.sub.2 CH.sub.3, --CN, --CHO, --NH.sub.2, --N(C.sub.1 -C.sub.6 alkyl).sub.2, --(CH.sub.2).sub.n COOH, and --(CH.sub.2).sub.n CN, where n is an integer from 1 to 4, inclusive, which comprises reacting a compound of the formula: ##STR30##wherein R.sup.1 and R.sup.2 are as above, with dimethyl carbonate in the presence of a suitable base or catalyst at ambient pressure.