Patent ID: 6153375
Filing Date: 2000-11-28
Classification: B01J,B32B,C07K,C40B,D21H,Y02P,Y10T

Abstract:
A method of making a library of compounds comprising the steps of:(a) individually identifying a plurality of discrete reaction zones on a laminar solid support material comprising a layer of a particulate, functionalized solid support resin affixed to a porous, inert, laminar material;(b) charging each of said reaction zones with a starting material;(c) sub-dividing the material to define at least two initial batches of reaction zones, wherein said batches are separated from one another;(d) applying at least two different reagents, one to each of the reaction zones in each initial batch, and recording the identity of those reaction zones to which each of said different reaction reagents is applied;(e) subjecting all reaction zones to reaction conditions which promote reaction to completion;(f) further sub-dividing each of said at least two initial batches into at least two alternative batches wherein said at least two alternative batches are separated from one another;(g) applying at least two different reagents, one to each of the reaction zones in each alternative batch, and recording the identity of those reaction zones to which each of said different reagents is applied;(h) subjecting all reaction zones to reaction conditions which promote reaction to completion; and(i) repeating steps (f) to (h) inclusive from zero to n times, as desired, wherein n is a whole number integer.