Patent ID: 8907071
Filing Date: 2014-12-09
Classification: A61K,A61P,C07K

Abstract:
1. A DNA encoding a composition of matter for extending the half-life of a polypeptide, of the formula or multimers thereof, wherein: F (i) a human IgG Fc domain or a portion thereof, (ii) a transthyretin protein domain, and (iii) a human serum albumin (HSA) protein domain; and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X P is a polypeptide of no more than about 80 amino acid residues in length, comprising the amino acid sequence of SEQ ID NO: 914, SEQ ID NO: 915, SEQ ID NO: 916, or SEQ ID NO: 917; L is a linker; and a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1.