Patent ID: 6696416
Filing Date: 2004-02-24
Classification: A61K,A61P,C12N,C12Y

Abstract:
A synthetic chemical peptide multimer comprising the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu (SEQ ID NO:2), or comprising(i) a substitution variant of SEQ ID NO:2, or (ii) an addition variant of SEQ ID NO:2 having up to 11 additional amino acids, the multimer having a formula: (P1â€”Xm)nâ€”P2 â€ƒwherein: (a) P1 and P2 are peptides either or both of which are SEQ ID NO:2, or said substitution or addition variant, and wherein P1 and P2 may be the same or different; (b) X is selected from the group consisting of C1-C20 alkyl, C1-C20 alkenyl, C1-C20 alkynyl, and C1-C20 polyether containing up to 9 oxygen atoms wherein m=0 or 1 and n=1-7 (c) said multimer is optionally capped at its N- and C-termini, and wherein said multimer has one or more of the following activities: (1) at least about 20% of the biological activity of Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-Am in an in vitro bioassay of cell invasion or endothelial tube formation; or (2) competes with labeled Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-Am for binding to a cell or molecule which has a binding site for Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-Am.