Patent ID: 6169179
Filing Date: 2001-01-02
Classification: C07D,Y02P

Abstract:
A method for manufacturing (3S,4R)-4-[(R)-1'-formylethyl]azetidin-2-one derivatives represented by formula (3): ##STR7## wherein R.sup.1 represents a hydrogen atom or a protective group for a hydroxyl group; through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1): ##STR8## wherein R.sup.1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2): ##STR9## wherein R.sup.2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom.