Patent ID: 8052979
Filing Date: 2011-11-08
Classification: A61P,C07K

Abstract:
1. A modified Clostridial toxin comprising: a) a Clostridial toxin enzymatic domain capable of executing an enzymatic target modification step of a Clostridial toxin intoxication process; b) a Clostridial toxin translocation domain capable of executing a translocation step of a Clostridial toxin intoxication process; c) a targeting domain comprising a polypeptide selected from the group consisting of a glucagon like hormone, such that the targeting domain is capable of executing a cell binding step of a Clostridial toxin intoxication process; and d) a protease cleavage site, wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form.