Patent ID: 6323240
Filing Date: 2001-11-27
Classification: A61P,C07C

Abstract:
A 4-phenyl-4-oxo-butanoic acid compound of formula (IA): ##STR8##either as single isomer, as a mixture of isomers thereof, or as a pharmaceutically acceptable salt thereof wherein:X and Y are, each independently, fluorine or chlorine;R is hydroxy; --OR.sub.5 in which R.sub.5 is C.sub.1 -C.sub.6 alkyl, phenyl benzyl, C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl; --N(R.sub.6).sub.2 or --N(R.sub.6)OR.sub.6 in which each of R.sub.6 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, phenyl or benzyl;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are, each independently, hydrogen, halogen hydroxy, cyano, thiol, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkyl C.sub.2 -C.sub.4 alkenyl, phenyl or benzyl, orR.sub.1 and R.sub.3 or R.sub.2 and R.sub.4 together form a group .dbd.CHR.sub.8 in which R.sup.8 is hydrogen, a straight C.sub.1 -C.sub.5 alkyl chain or phenyl;provided that:(i) when X and Y are both chlorine and R.sub.1, R.sub.2 and R.sub.4 are simultaneously hydrogen, R.sub.3 is different from hydrogen, hydroxy, methoxy, ethylthio or isopropylthio; and(ii) when X and Y are both fluorine, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not simultaneously hydrogen.