Patent ID: 8703194
Filing Date: 2014-04-22
Classification: A61K,C08F

Abstract:
1. A stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, the stimulus-responsive pendant group being a stimulus-responsive monomer which provides stimulus-responsiveness to the polymer, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone the polymer comprises one or more units each independently selected from a unit of formula I: and a unit of formula II: and optionally comprises one or more units, each independently selected from formula III: wherein: z is O or NH; each of R 1 , R 3 and R 8 is independently hydrogen, hydroxyl, halide, thiohydroxyl or hydrocarbyl; R 2 is unsubstituted or substituted C 1-30 alkylene optionally containing one or more heteroatoms selected from the group consisting of N, O and S; unsubstituted or substituted C 2-30 alkenylene optionally containing one or more heteroatoms selected from the group consisting of N, O and S; or unsubstituted or substituted C 2-30 alkynylene optionally containing one or more heteroatoms selected from the group consisting of N, O and S; R 5 is: (i) unsubstituted or substituted C (ii) —R R 4 is: (i) hydrocarbyl; or (ii) when R R 9 is: (i) unsubstituted or substituted C (ii) —R R 10 is (i) hydrocarbyl; or (ii) when R with the proviso that R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , R 9 and R 10 cannot have a primary amino group, a secondary amino group, or a C═C double bond conjugated with a carbonyl group.