Patent ID: 6645770
Filing Date: 2003-11-11
Classification: A61K,G01N,G16H

Abstract:
A method of predicting increased risk of prostate cancer in an individual, comprising:measuring the concentration of PSA in a body fluid from the individual; comparing the concentration of PSA to a predetermined reference value, and designating the individual's PSA concentration as in a low or high level compared to the reference value; measuring the concentration of total IGF-I in a body fluid from the individual; measuring the concentration of total IGFBP-3 in a body fluid from the individual; designating a risk of prostate cancer within the PSA level for the individual, including: i) conducting a multivariate adjustment of the total IGF-I concentration relative to the total IGFBP-3 concentration to provide a risk value within the PSA level; and ii) matching the individual risk value to a predetermined risk quartile value within the PSA level, wherein a risk value in the highest quartile corresponds to at least four times as great a risk of prostate cancer.