Patent ID: 6068837
Filing Date: 2000-05-30
Classification: A61K,A61P,C07K,C12N

Abstract:
A mesothelial cell graft, comprising,a support suitable for implantation into a mesothelial cell-compatible site of a mammalian recipient; and a plurality of genetically modified non-immortalized mesothelial cells attached to said support, wherein the genetically modified mesothelial cells are from the same species as the mammalian recipient and contain an expression vector for expressing in the genetically modified mesothelial cells a therapeutic agent for treating a condition that is treatable by local delivery of the therapeutic agent to the mesothelial cell-compatible site, wherein the therapeutic agent is secreted from the non-immortalized mesothelial cell and wherein the expression vector is useful for expressing the therapeutic agent in somatic cell types for human gene therapy.