Patent ID: 7915386
Filing Date: 2011-03-29
Classification: A61K,A61P,C07K

Abstract:
1. A method for producing an interferon-β complex, comprising specifically binding interferon-β comprising the amino acid sequence of SEQ ID NO: 1, or a mutant thereof which has antiviral activity and comprises a deletion of Met 1 and a substitution of Cys 17 with Ser in the amino acid sequence of SEQ ID NO: 1, to polyethylene glycol, at a lysine located at the 19 th or 134 th position of the interferon-β, or at a lysine located at a position corresponding thereto of the mutant, in an amino acid sequence of the interferon-β or the mutant thereof, in the presence of at least one additive selected from the group consisting of disaccharides, monosaccharides, sugar alcohols thereof, and C 2-3 polyhydric alcohols.