Patent ID: 9006472
Filing Date: 2015-04-14
Classification: C07F

Abstract:
1. A process of preparing a compound represented by Formula A wherein the compound is 13 C labeled at one or more carbon atoms marked with an asterisk, R 1 * and R 2 * are the same or different 13 C labeled saturated, unsaturated, or polyunsaturated C 1 -C 28 hydrocarbon chains comprising at least one 13 C labeled carbon atom, and optionally derived from fatty acids; and R 3 is hydrogen or a C 1 -C 3 alkyl group, the process comprising: a) protecting the diol present in b) coupling the primary alcohol in the compound of Formula 2 with an allyl halide to obtain a compound represented by Formula 3: c) deprotecting the ketal present in the compound represented by Formula 3 to obtain a compound represented by Formula 4 d) protecting the diol present in the compound represented by Formula 4 using a protecting agent to obtain a compound represented by Formula (v): e) reacting a f) deprotecting the ether groups present in the compound represented by Formula (vi) to obtain a compound represented by Formula 7 g) protecting the primary alcohol present in the compound represented by Formula 7 using a protecting agent to obtain a compound represented by Formula (viii) h) esterifying a i) deprotecting the ether present in the compound represented by Formula (ix) to yield a compound represented by Formula 10 and j) reacting POCl