Patent ID: 8278451
Filing Date: 2012-10-02
Classification: A61P,C07D

Abstract:
1. A compound having a general structural formula (I) or formula (II): wherein R 1 , R 5 , and R 7 are the same or different and are independently selected from the group consisting of hydrogen, C 1-4 alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, tris(3-hydroxypropyl)methyl, (3-carboxy-1,1-dimethyl)propyl, and 3-sulfonatophenyl; R 2 , R 6 , and R 9 are the same or different and are selected from the group consisting of hydrogen, C═C(H)N + (R 1 )O − , C 1-22 alkyl, C 1-10 alkyleneOC(O)C 1-10 alkyl, and CHO; R 3 is selected from the group consisting of hydrogen, C 1-22 alkyl, SR 12 , and SO 3 − ; X is selected from the group consisting of O, S, and NR 4 ; X′ is selected from the group consisting of O, S, and NR 8 ; R 4 and R 8 are the same or different and are selected from the group consisting of hydrogen, C 1-22 alkyl, phenyl, substituted phenyl, (C 1-22 alkyleneN(R 12 ) 2 + ) n C 1-22 alkyleneN(R 12 ) 2 , C 1-22 alkyleneOR 11 , C 1-22 alkyleneP(R 1 ) 3 + , C 1-22 alkylene aryl, C 1-22 alkylene substituted aryl, C 1-22 alkylene heteroaryl, and C 1-22 alkylene substituted heteroaryl; R 10 is independently selected from the group consisting of hydrogen, C 1-10 alkyl, C 1-10 alkyleneN(R 12 ) 3 + , and C 1-10 alkylene-C 6 H 4 —C 1-10 alkyleneN(R 12 ) 3 + ; R 11 is selected from the group consisting of hydrogen, C 1-10 alkyl, SO 2 CF 3 , SO 2 CH 3 , SO 2 C 6 H 4 CH 3 , and SO 2 C 4 F 9 ; and R 12 is selected from the group consisting of hydrogen, C 1-22 alkyl, aryl, heteroaryl, substituted aryl, and substituted heteroaryl; n is an integer from 0 to 3; or a pharmaceutically acceptable salt thereof.