Patent ID: 6166069
Filing Date: 2000-12-26
Classification: C07D

Abstract:
A compound of formula I having the structure ##STR5## wherein: A is O, or S;B is --(CH.sub.2).sub.m --;R.sup.1 is hydrogen, nitro, halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or trifluromethyl;R.sup.2 is aryl of 6-10 carbon atoms, arylalkyl of 7-15 carbon atoms;R.sup.3, R.sup.4 are each, independently, hydrogen, halogen, alkyl of 1-3 carbon atoms, or alyl of 6-10 carbon atoms;R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, --CH(R.sup.7)R.sup.8, --C(CH.sub.2).sub.n COR.sup.9, --C(CH.sub.3).sub.2 CO.sub.2 R.sup.9, --CH(R.sup.7)(CH.sub.2).sub.n CO.sub.2 R.sup.9, or CH(R.sup.7)C.sub.6 H.sub.4 CO.sub.2 R.sup.9 ;R.sup.6 is hydrogen, halogen, alkyl of 1-6 carbon atoms, or --OR.sup.5 ;m=1-6;n=1-6;R.sup.7 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms;R.sup.8 is --CO.sub.2 R.sup.10, --CONHR.sup.10, tetrazole, or --PO.sub.3 ;R.sup.9 and R.sup.10 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms;m=1or a pharmaceutically acceptable salt thereof.