Patent ID: 7365094
Filing Date: 2008-04-29
Classification: C07D

Abstract:
1. A compound of the general formula (II) and salts and physiologically functional derivatives thereof, wherein A is a heteroaromatic 5-membered ring system containing one or more groups X selected from the group consisting of S, O, N, NR D is O, S, SO Z R R* independently represents H, alkyl, cycloalkyl, aminoalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R′ independently represents H, —CO R″ independently represents hydrogen, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl; R R R R R R E is a monocyclic or polycyclic substituted or unsubstituted ring system which contains at least one aromatic ring and which may also contain one or more groups X selected form S, O, N, NR Y is a phenyl substituted by one or more substituents R′; m is 0 or 1; n is 0 or 1; p is 0 or 1; q is 0 or 1; s is 0 to 2; and t is 0 to 3; with the proviso that the following compounds are excluded: compounds wherein ring A contains five atoms, Z′=Z 2 =O, and R 2 together with the nitrogen atom which is attached to R 8 forms a 5 membered heteroyclic ring with the proviso that R 2 is—[CH 2 ] 8 , R 8 is absent and s is 0; compounds wherein ring A contains three carbon atoms and two nitrogen atoms, Z 4-[4-(naphthalin-2-yl) thiazol-2-ylaminocarbonyl]-furan-3-carboxylic acid; and 5-[4-(naphthalin-2-yl) thiazol-2-ylaminocarbonyl]-2H-[1,2,3]-triazole-4-carboxylic acid.