Patent ID: 7285268
Filing Date: 2007-10-23
Classification: A61K,A61P,C07K

Abstract:
1. A method of treatment of an angiogenesis-associated ocular disease comprising applying one or more doses of an anti-α5β1 integrin antibody to an injured eye tissue, wherein the anti-α5β1 integrin antibody comprises: a) a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:1, a light chain variable region consisting of the amino acid sequence of SEQ ID NO:7, and a constant region, wherein the source of the constant region is a human IgG; b) a heavy chain consisting of the amino acid sequence of SEQ ID NO: 25 and a light chain consisting of the amino acid sequence of SEQ ID NO: 26; c) a heavy chain consisting of the amino acid sequence of SEQ ID NO: 28 and a light chain consisting of the amino acid sequence of SEQ ID NO: 26; or d) a heavy chain consisting of the amino acid sequence of SEQ ID NO: 31 and a light chain consisting of the amino acid sequence of SEQ ID NO: 32.