Patent ID: 8945036
Filing Date: 2015-02-03
Classification: A61M

Abstract:
1. A system for regional citrate anticoagulation in an extracorporeal blood circuit including an arterial blood line arranged to be connected to a vascular access for withdrawing blood from a patient and a venous blood line arranged to be connected to the vascular access for returning blood to the patient, the system comprising: a hemofilter in fluid communication with the arterial and venous blood lines; a first pre-filter infusion line connected to the arterial blood line upstream from the hemofilter for infusing a first pre-filter infusion solution comprising a citrate anticoagulant-containing solution into blood in the arterial blood line; a second pre-filter infusion line connected to the arterial blood line upstream from the hemofilter for infusing a second pre-filter infusion solution comprising a first bicarbonate-containing solution into blood in the arterial blood line; an effluent fluid line in fluid communication with the hemofilter for carrying effluent fluid away from the hemofilter; a post-filter infusion line connected to the venous blood line downstream from the hemofilter for infusing a post-filter infusion solution comprising a second bicarbonate-containing solution into blood in the venous blood line; an additional infusion line connected to the venous blood line downstream from a connection of the post-filter infusion line for infusing an additional infusion solution comprising a calcium- and magnesium-containing solution into blood in the venous blood line; and at least one arterial hematocrit sensor operably connected to the arterial blood line upstream from the second pre-filter infusion line for providing circuit plasma flow in real time for controlling at least one of hemofilter single pass citrate extraction and an infusion rate of the additional infusion solution.