Patent ID: 6180631
Filing Date: 2001-01-30
Classification: A61K,A61P,C07D

Abstract:
A method of preventing or treating an abnormal condtion in a mammal, wherein said abnormal condition is associated with an aberration in a signal transduction pathway characterized by an interaction between the serine/threonine protein kinase RAF and a natural binding partner, said method comprising the step of administering a 5-azaquinoxaline-based compound of formula I to said organism ##STR8##wherein R.sub.3 and R.sub.4 are hydrogen, R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, methyl, phenyl and 4-hydroxyphenyl, and R.sub.6 and X.sub.1 substituents together form a moiety selected from the group consisting of methoxy, benzylamino, 4-fluorobenzylamino, 2-carboxybenzylamino, 3-carboxybenzylamino, 4-carboxybenzylamino, 2-nitrobenzylamino, 3-nitrobenzylamino, 4-nitrobenzylamino, 2-methylbenzylamino, 3-methylbenzylamino, 4-methylbenzylamino, 2-chlorobenzylamino, 3-chlorobenzylamino, 4-chlorobenzylamino, 2-fluorobenzylamino, 3-fluorobenzylamino, 4-fluorobenzylamino, 2-(trifluoromethyl)benzylamino, 3-(trifluoromethyl)benzylamino, 4-(trifluoromethyl)benzylamino, phenethyl-1-amino, phenylamino, 2-carboxyphenylamino, 3-carboxyphenylamino, 4-carboxyphenylamino, 2-nitrophenylamino, 3-nitrophenylamino, 4-nitrophenylamino, 2-methylphenylamino, 3-methylphenylamino, 4-methylphenylamino, 2-chlorophenylamino, 3-chlorophenylamino, 4-chlorophenylamino, 2-fluorophenylamino, 3-fluorophenylamino, 4-fluorophenylamino, 2-(trifluoromethyl)phenylamino, 3-(trifluoromethyl)phenylamino, 4-(trifluoromethyl)phenylamino, pyrid-2-amino, pyrid-3-amino, pyrid-4-amino, and pyrid-2-methylamino.