Patent ID: 6689777
Filing Date: 2004-02-10
Classification: A61K,Y02A

Abstract:
A method for depolymerizing hemozoin in a mammal infected with malaria comprising administering to said mammal a hemozoin-depolymerizing effective amount of a compound of the formula wherein R1 is hydrogen, alkenyl, hydroxy(lower)alkyl, di[(lower)alkyl]amino(lower)alkyl, a heterocyclic group or a lower alkyl group optionally substituted by a heterocyclic group; R2 is cycloalkyl, alkenyl, lower alkyl, hydroxy(lower alkyl), di[hydroxy(lower)alkyl]amino(lower)alkyl, a heterocyclic group, or an aryl group optionally substituted by a 1-(guanylhydrazono)alkyl group; R3 is hydrogen or a 1-(guanylhydrazono)alkyl group; or a pharmaceutically acceptable salt therefor.