Patent ID: 8828443
Filing Date: 2014-09-09
Classification: A61J,A61K,A61P,B01J

Abstract:
1. A process for producing a pharmaceutical composition comprising the steps: (a) forming a feed solution comprising a drug, a polymer and a solvent, wherein said polymer is selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, carboxymethyl ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl methyl cellulose phthalate, cellulose acetate phthalate, cellulose acetate trimellitate, vinyl polymers and copolymers having at least one substituent selected from the group consisting of hydroxyl, alkylacyloxy, and cyclicamido, and polyvinyl alcohols that have at least a portion of their repeat units in hydrolyzed form, polyvinyl pyrrolidone, poloxamers, and blends thereof; (b) directing said feed solution to a spray-drying apparatus comprising (i) a drying chamber having a volume V (ii) atomizing means for atomizing said feed solution into droplets, and (iii) a source of heated drying gas for drying said droplets, said source delivering said drying gas to said drying chamber at a flow rate of G, wherein V H is at least 1.0 m, G is measured in m and wherein the following mathematical relationship is satisfied (c) atomizing said feed solution into droplets in said drying chamber by said atomizing means; (d) contacting said droplets with said heated drying gas to form particulates of a solid amorphous dispersion of said drug homogeneously distributed throughout said polymer; and (e) collecting said particulates.