Patent ID: 8252319
Filing Date: 2012-08-28
Classification: A61F,A61K,A61P

Abstract:
1. A transdermal delivery system, comprising: a pressure sensitive adhesive matrix comprising sufentanil in an amount above the saturation point of sufentanil in said matrix, wherein the matrix comprises: both dissolved and undissolved sufentanil, and a blend of high molecular weight polyisobutylene and low molecular weight polyisobutylene, the high molecular weight polyisobutylene having a viscosity average molecular weight of about 450,000 to 2,100,000, the low molecular weight polyisobutylene having a viscosity average molecular weight of about 1,000 to 450,000, polybutene, and silicon dioxide; wherein said system, when applied to a subject as a single patch over a single application administration period of 3 or more days, provides sustained analgesia in said subject for 3 or more days by delivery of sufentanil from said system with a coefficient of variation (ΔJ wherein said system does not comprise a rate controlling membrane.