Patent ID: 6211197
Filing Date: 2001-04-03
Classification: A61P,C07C,C07D

Abstract:
A compound represented by formula II:Ar.sup.1 --W--Ar.sup.2 --X--Q IIor a pharmaceutically acceptable salt or hydrate thereof, wherein:Ar.sup.1 is benzene, naphthalene, benzofuran or methylenedioxyphenyl, optionally substituted by R.sup.1 and R.sup.3 ;R.sup.1 is OH, OCH.sub.2 Ar.sup.3, SCH.sub.2 Ar.sup.3, OAr.sup.3, SAr.sup.3 or NR.sup.2 CH.sub.2 Ar.sup.3 ;R.sup.3 is R.sup.4, halogen, haloC.sub.1-6 alkyl, N(R.sup.5).sub.2, CN, NO.sub.2, C(R.sup.6).sub.3, CON(R.sup.5).sub.2, OR.sup.4, SR.sup.4 or S(O).sub.n R.sup.7 ;R.sup.4 is H, lower alkyl, lower alkenyl, lower alkynyl, CHF.sub.2 or CF.sub.3 ;R.sup.5 is R.sup.4, Ph or Bn, or two R.sup.5 groups in combination with the atom to which they are attached represent a ring of up to 6 members containing carbon atoms and up to 2 heteroatoms selected from O, N and S;R.sup.6 is H, F, CF.sub.3 or lower alkyl, or two R.sup.6 groups may be taken together and represent a ring of up to 6 members containing carbon atoms and 0-2 heteroatoms selected from O, N and S;R.sup.7 is lower alkyl, lower alkenyl, lower alkynyl, CHF.sub.2, CF.sub.3, N(R.sup.5).sub.2, Ph(R.sup.8).sub.2 or CH.sub.2 Ph(R.sup.8).sub.2 ;R.sup.8 is R.sup.4, OR.sup.4, SR.sup.4 or halogen;Ar.sup.3 is selected from the group consisting of benzene, pyridine, thiophene, furan, oxazole and thiazole, said group being optionally substituted with R.sub.3 ;Ar.sup.2 is benzene, optionally substituted with 1-4 members selected from the group consisting of: R.sup.4, OR.sup.4, SR.sup.4 and halogen;W is selected from the group consisting of: CH.sub.2 OCH.sub.2, (CH.sub.2).sub.3, CH.sub.2 CH.dbd.CH, CH.dbd.CHCH.sub.2, CH(OH)CH.dbd.CH, CH.dbd.CHCH(OH), CH.sub.2 C.tbd.C, C.tbd.CCH.sub.2 1,2-c-Pr--CH.sub.2 -- and --CH.sub.2 -1,2-c-Pr--;X represents a linker which is attached to Ar.sup.2 ortho to the attachment of W and is selected from the group consisting of: (CH.sub.2).sub.2, CH.dbd.CH, C.tbd.C and 1,2-c-Pr;and Q is CO.sub.2 H or tetrazole.