Patent ID: 7256188
Filing Date: 2007-08-14
Classification: A61P,C07D

Abstract:
1. A compound of formula I or a salt, pro-drug or solvate thereof wherein for A, either:— (i) A represents hydrogen or optionally substituted C (ii) the structure N—A(—R B represents a direct bond or optionally substituted C C represents a mono- or bi-cyclic aromatic ring structure optionally having at least one substituent selected from CN, NR D represents hydrogen; optionally substituted C E is selected from an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from O, N and S; or a group of formula II; III; IV; V; VI, VII or VIII wherein het represents an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from O, N and S; for X and Y, either:— (iii) X represents N and Y represents CN; hydrogen or —CONR (iiia) X represents CH and Y represents NO (iv) X—Y represents O; For R 1 and R 2 , either:— (v) R (vi) R (vii) represents an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 3 further heteroatoms independently selected from O, N and S, and R 2 meets the definition in option (v); R R R for R 7 and R 7a , either:— (viii) R (ix) represents an optionally substituted 3 to 7-membered cycloalkyl ring; for R 8 and R 9 , either:— (x) R and an optionally substituted 3- to 8-membered heterocyclic ring optionally containing from 1 to 3 further heteroatoms independently selected from O, N and S; and R (xi) wherein E represents a group of formula II or III, then the group NR (xii) wherein E represents structure VI, represents an optionally substituted 3- to 8-membered heterocyclic ring optionally containing from 1 to 4 heteroatoms independently selected from O, N and S; with the proviso that: when A is C