Patent ID: 6369070
Filing Date: 2002-04-09
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I: where:R is (CH2)m, CHR1NHR2, O(CH2)2NR2, (CH2)mCOR3, NHR2, and (CH2)m, CHR1NR4R5; Râ€² is hydrogen, hydroxy, or O(C1-C6 alkyl optionally substituted with phenyl or C3-C7 cycloalkyl); m and mâ€² are independently at each occurrence 0, 1, or 2; R1 is independently at each occurrence hydrogen or C1-C6 alkyl; R2 is hydrogen, COR6, CH2R6â€², SO2R7, or a moiety of the formula R3 is hydrogen, hydroxy, C1-C6 alkoxy, an amino ester, an amino acid, or NR4R5; R4 is hydrogen or C1-C6 alkyl; R5 is hydrogen, C1-C6 alkyl, C6-C10 bicycloalkyl, CH2CH(CH3)phenyl, CH(CH3)CH2CO2R1, aryl, substituted aryl, or R4 and R5 combine to form a pyrrolidin-1-yl or piperidin-1-yl; n is 1, 2, 3, or 4; q is 0, 1, 2, or 3; R6 is C1-C6 alkyl, substituted C3-C6; cycloalkyl, aryl, substituted aryl, or tert-butoxy; R6â€² is C1-C6 alkyl, substituted C3-C6 cycloalkyl, aryl, or substituted aryl; r is 0, 1, or 2; R7 is C1-C6 alkyl, phenyl or substituted phenyl; and R8 is hydrogen or CO2R1; or a pharmaceutical salt or solvate thereof.