Patent ID: 8669247
Filing Date: 2014-03-11
Classification: A61P,C07C,C07D

Abstract:
1. A method for the treatment, or amelioration of one or more symptoms of asthma, allergic asthma, exercise induced asthma, allergic rhinitis, perennial allergic rhinitis, seasonal allergic rhinitis, atopic dermatitis, conjunctivitis, allergic conjunctivitis, eosinophilic bronchitis, eosinophilic gastroenteritis, allograft rejection, chronic obstructive pulmonary disease, COPD (chronic obstructive pulmonary disorder), arthritis, rheumatoid arthritis, psoriatic arthritis, or osteoarthritis in a subject, which comprises administering to the subject a compound of Formula I: or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, or a mixture of two or more tautomers thereof; or a pharmaceutically acceptable salt or prodrug thereof; wherein: R R R R X is O or S; Y is —O—, —S—, —S(O)—, —S(O) m is an integer from 0 to 3; n is an integer from 1 to 3; p is an integer from 0 to 4; r is an integer from 1 to 6; and each R each pair of R with the proviso that when X is O; Y is —N(R