Patent ID: 9017688
Filing Date: 2015-04-28
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a cancer associated with the over-expression of the gene of SEQ ID NO: 1 in a subject, said method comprising administering to said subject a vaccine comprising one or more isolated peptide(s) of less than 15 amino acids, said peptide having cytotoxic T cell inducibility and comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 7 and 8, in which 1 or 2 amino acids are substituted; wherein, (i) the second amino acid from the N-terminus of the amino acid sequence of SEQ ID NO: 7 or 8 is substituted with phenylalanine, methionine, or tryptophan, and/or (ii) the C-terminal amino acid of the amino acid sequence of SEQ ID NO: 7 or 8 is substituted with phenylalanine, leucine, isoleucine, tryptophan, or methionine.