Patent ID: 8946388
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K

Abstract:
1. An antibody which has the ability of binding to GT468 and has one or more of the following activities: (i) killing of tumor cells expressing GT468, (ii) inhibition of proliferation of tumor cells expressing GT468, (iii) inhibition of colony formation of tumor cells expressing GT468, and (iv) inhibition of metastasis of tumor cells expressing GT468, wherein the antibody is selected from the group consisting of: (i) an antibody produced by or obtainable from a clone deposited under the accession no. DSM ACC2961 (42H11 1C11 2B2), DSM ACC2962 (51G6 2H3 2B4), DSM ACC2943 (16-5B-1), DSM ACC2956 (20-11A-1), DSM ACC2947 (29-1A-2), DSM ACC2964 (29-8B-1), DSM ACC2959 (35-48B-1), DSM ACC2963 (35-50A-2a), DSM ACC2957 (38-10B-1), DSM ACC2958 (38-1A-1), DSM ACC2948 (44-3A-2), DSM ACC2949 (45-2A-1), DSM ACC2950 (45-8A-2), DSM ACC2951 (48-3B-1), DSM ACC2952 (48-4A-1), DSM ACC2946 (49-3A-1), DSM ACC2945 (49-8A-1), DSM ACC2944 (51-1A-1), DSM ACC2953 (53-13A-2), DSM ACC2955 (53-29A-1), DSM ACC2960 (54-4B-2), DSM ACC2954 (56-4A-2), or DSM ACC3001 (62-9B-1), (ii) an antibody which is a chimerized or humanized form of the antibody under (i), and (iii) an antibody comprising the antigen binding portion of the antibody under (i).