Patent ID: 6352502
Filing Date: 2002-03-05
Classification: A61B,G01N

Abstract:
A method for obtaining an enhanced target signal containing spectroscopic information from living tissue of a subject comprising:(a) irradiating a tissue of interest in a subject with light having an excitation wavelength and that passes from a light source through a first adjustable lens along a first optical axis; (b) passing spectra that are emitted by the tissue through a second adjustable lens along a second optical axis; (c) collecting spectra that are passed through the second adjustable lens; (d) analyzing the collected spectra to determine a target signal associated with an analyte of interest; (e) adjusting the position of the first adjustable lens or the second adjustable lens along the optical axis of the lens; (f) repeating steps (a)-(d); (g) deriving a correction signal based on the difference between the target signal obtained before and after the adjusting of step (e); and (h) adjusting the position of the first adjustable lens or the second adjustable lens along the optical axis of the lens on the basis of the correction signal so as to enhance the target signal.