Patent ID: 6506415
Filing Date: 2003-01-14
Classification: A61K,C12N

Abstract:
A method of screening a pro-apoptotic agent for anti-cancer activity in a mammal having cancer comprising the steps of:providing an in vitro tumor cell culture supplemental with said pro-apoptotic agent; placing said tumor cells from said tumor cell culture into a diffusion chamber, thereby producing a tumor cell-containing diffusion chamber; inserting said tumor cell-containing diffusion chamber into said mammal for a period of time; and removing said tumor cell-containing diffusion chamber and evaluating the anti-cancer effects of said pro-apoptotic agent by determining the inhibition of growth of the tumor cells in said mammal or the presence or absence of tumors in said mammal; wherein said tumor cell is a glioblastoma tumor cell, pancreatic tumor cell, melanoma tumor cell, prostate tumor cell, ovary tumor cell, mammary tumor cell, lung tumor cell, colon tumor cell, or smooth muscle tumor cell.