Patent ID: 6777414
Filing Date: 2004-08-17
Classification: A61P,C07D

Abstract:
A compound represented by formula (I) or a pharmacologically acceptable salt or solvate thereof: whereinR1 and R2, which may be the same or different, represent alkyl having 1 to 6 carbon atoms which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom, alkoxy having 1 to 6 carbon atoms which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom, cycloalkyl having 3 to 8 carbon atoms which is optionally substituted by alkyl having 1 to 6 carbon atoms; hydroxyl; halogen atom; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; benzyl; or alkylcarbonyloxy having 2 to 5 carbon atoms, phenyl which is optionally substituted by alkyls having 1 to 6 carbon atoms; hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkylcarbonyl having 2 to 5 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom; trifluoromethyl; or nitro, alkenyl having 2 to 6 carbon atoms which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic rings containing one hetero-atom, alkynyl having 2 to 6 carbon atoms which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic rings containing one hetero-atom, or a heterocyclic ring which is selected from pyridine, thiophene, pyrrole, furan, pyrazole, imidazole, oxazole, thiazole, pyran, pyridazine, pyrimidine, pyrazine, and oxane, wherein one of more hydrogen atoms on the ring are optionally subsititeud by alkyls having 1 to 6 carbon atoms; hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; and benzyl or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a piperazine, piperidine, or 3,4-dihydro-1H-isoquinolinone ring where one of more hydrogen atoms on the ring may be substituted by alkyl having 1 to 6 carbon atoms; hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyls; or benzyl; R3 and R4, which may be the same or different, represent a hydrogen atom, alkyl having 1 to 6 carbon atoms which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl having 2 to 5 carbon atoms, alkoxy having 1 to 6 carbon atoms, or carboxyl, A, D, E, and G each represent a carbon atom, Q represents a nitrogen atom, q represents a single bond; Y represents a group represented by formula (II): â€ƒwherein X represents a hydrogen atom; group â€”C(&boxH;O)N(R5)R6 wherein R5 and R6, which may be the same or different, represent a hydrogen atom, alkyl having 1 to 6 carbon atoms (which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom), cycloalkyl having 3 to 8 carbon atoms (which is optionally substituted by alkyl having 1 to 6 carbon atoms; hydroxyl; halogen atom; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to S carbon atoms; C3-8 cycloalkyl; phenyl; benzyl; or alkylcarbonyloxy having 2 to 5 carbon atoms), phenyl (which is optionally substituted by alkyls having 1 to 6 carbon atoms; hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkylcarbonyl having 2 to 5 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom; trifluoromethyl; or nitro), alkenyl having 2 to 6 carbon atoms (which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic rings containing one hetero-atom), or alkynyl having 2 to 6 carbon atoms (which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic rings containing one hetero-atom); or group â€”C(&boxH;O)OR7 wherein R7 represents a hydrogen atom or alkyl having 1 to 6 carbon atoms (which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom), R8 represents two hydrogen atoms to make the group of formula (II) diphenylmethyl or represents a bond, an oxygen atom, a sulfur atom, â€”SO2â€”, â€”SOâ€”, â€”CH2â€”CH2â€”, or â€”CH&boxH;CHâ€”, and R9 and R10, which may be the same or different, represent a hydrogen atom, alkyl having 1 to 6 carbon atoms (which is optionally substituted by hydroxyl; halogen; amino; alkoxy having 1 to 6 carbon atoms; alkoxycarbonyl having 2 to 5 carbon atoms; C3-8 cycloalkyl; phenyl; biphenyl; amino substituted by alkyl having 1 to 6; or five- or six-membered saturated or unsaturated heteroaromatic ring containing one hetero-atom), alkoxy having 1 to 6 carbon atoms, a halogen atom, or hydroxyl; and Z represents â€”(CH2)nâ€”, wherein n is an integer of 0 to 6, â€”Oâ€”(CH2)iâ€”, or â€”C(&boxH;O)NHâ€”(CH2)iâ€” wherein i is an integer of 1 to 6.