Patent ID: 6147071
Filing Date: 2000-11-14
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR53## wherein ring M is a heterocyclic ring wherein --X. . . . . Y<is --N.dbd.C<;and n is an integer from 1 to 6, or a salt thereof;R.sup.a and R.sup.b are the same or different and represent, independently,(1) a hydrogen atom,(2) a C.sub.1-6 alkyl group optionally having from 1 to 5 substituents selected from(a) a hydroxyl group,(b) a C.sub.1-6 alkoxy group,(c) a C.sub.1-6 alkylthio group,(d) an amino group,(e) a C.sub.1-7 acylamino group,(f) a carboxyl group,(g) a nitro group,(h) a mono- or di-C.sub.1-6 alkylamino group,(i) a mono- or di-C.sub.1-6 cycloalkylamino group,(j) a C.sub.6-10 arylamino group,(k) a 5-membered to 9-membered cyclicamino group which may have 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms in addition to the nitrogen atom in the amino group,(l) a 5-membered to 6-membered aromatic heterocyclic group having from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to carbon atoms,(m) a 5-membered to 9-membered non-aromatic heterocyclic ring having from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to carbon atoms,(n) a C.sub.1-4 alkylsulfonylamino group,(o) a C.sub.1-6 alkyl-carbonyloxy group and(p) a halogen atom,(3) an optionally halogenated C.sub.1-6 alkoxy group,(4) an optionally halogenated C.sub.1-6 alkylthio group,(5) a C.sub.3-10 cycloalkyl group,(6) a C.sub.6-10 aryl group,(7) a C.sub.1-7 acylamino group,(8) a C.sub.1-3 acyloxy group,(9) a hydroxy group,(10) a nitro group,(11) a cyano group,(12) an amino group,(13) a mono- or di-C.sub.1-6 alkylamino group,(14) a 5-membered to 9-membered cyclicamino group which may have 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group,(15) a C.sub.1-6 alkylcarbonylamino group,(16) a C.sub.1-6 alkylsulfonylamino group,(17) a C.sub.1-6 alkoxycarbonyl group,(18) a carboxyl group,(19) a C.sub.1-6 alkylcarbonyl group,(20) a carbamoyl group,(21) a mono- or di-C.sub.1-6 alkylcarbamoyl group,(22) C.sub.1-6 alkylsulfonyl group;the Ring B is a benzene ring which may have 1 to 4 substituents selected from(1) a halogen atom,(2) a C.sub.1-6 alkyl group optionally having from 1 to 5 substituents selected from(a) a hydroxyl group,(b) an amino group,(c) a carboxyl group,(d) a nitro group,(e) a mono- or di-C.sub.1-6 alkylamino group,(f) a C.sub.1-6 alkyl-carbonyloxy group and(g) a halogen atom,(3) an optionally halogenated C.sub.1-6 alkoxy group,(4) an optionally halogenated C.sub.1-6 alkylthio group,(5) a C.sub.6-10 aryl group,(6) a C.sub.1-7 acylamino group,(7) a C.sub.1-3 acyloxy group,(8) a hydroxy group,(9) a nitro group,(10) a cyano group,(11) an amino group,(12) a mono- or di-C.sub.1-6 alkylamino group,(13) a 5-membered to 9-membered cyclicamino group which may have 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group,(14) a C.sub.1-6 alkylcarbonylamino group,(15) a C.sub.1-6 alkylsulfonylamino group,(16) a C.sub.1-6 alkoxycarbonyl group,(17) a carboxyl group,(18) a C.sub.1-6 alkylcarbonyl group,(19) a carbamoyl group,(20) a mono- or di-C.sub.1-6 alkylcarbamoyl group,(21) a C.sub.1-6 alkylsulfonyl group;the Ring C is a benzene ring optionally having 1 to 5 substituents selected from(1) a halogen atom,(2) an optionally halogenated C.sub.1-10 alkyl group,(3) an amino-substituted C.sub.1-4 alkyl group,(4) a mono- or di-C.sub.1-4 alkylamino-substituted C.sub.1-4 alkyl group,(5) a carboxyl-substituted C.sub.1-4 alkyl group,(6) a hydroxy-substituted C.sub.1-4 alkyl group,(7) a C.sub.1-4 alkoxy-carbonyl-substituted C.sub.1-4 alkyl group,(8) a C.sub.3-10 cycloalkyl group,(9) a nitro group,(10) a cyano group,(11) a hydroxyl group,(12) an optionally-halogenated C.sub.1-10 alkoxy group,(13) an optionally-halogenated C.sub.1-4 alkylthio group,(14) an amino group,(15) a mono- or di-C.sub.1-4 alkylamino group,(16) a 5-membered to 9-membered cyclic amino group optionally having 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group,(17) a C.sub.1-4 alkyl-carbonylamino group,(18) an aminocarbonyloxy group,(19) a mono- or di-C.sub.1-4 alkylaminocarbonyloxy group,(20) a C.sub.1-4 alkylsulfonylamino group,(21) a C.sub.1-4 alkoxy-carbonyl group,(22) an aralkyloxycarbonyl group,(23) a carboxyl group,(24) a C.sub.1-6 alkyl-carbonyl group,(25) a C.sub.3-6 cycloalkyl-carbonyl group,(26) a carbamoyl group,(27) a mono- or di-C.sub.1-4 alkylcarbamoyl group,(28) a C.sub.1-6 alkylsulfonyl group and(29) a 5-membered or 6-membered aromatic monocyclic heterocyclic group having 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, which may have 1 to 3 substituents selected from an optionally halogenated C.sub.1-4 alkyl;the Ring Z is ##STR54## wherein p is an integer of from 2 to 5 and Z.sub.2 is a hydrogen atom, an C.sub.1-4 alkyl group or a hydroxyl group.