Patent ID: 7262187
Filing Date: 2007-08-28
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: Y is CH; W is selected from S and O; the dashed line represents a double bond between W and Y, provided W is CH, or a double bond between positions 5 and 6, provided W is S or O; a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; n is 0 to 2; u is 2, 3, 4 or 5; R 1 is selected from: 1) H, 2) C 3) aryl, 4) C 5) C 6) C 7) C 8) C 9) heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, aralkyl and heterocyclyl is optionally substituted with one or more sub stituents selected from R 5 ; R 2 and R 2 ′ are independently selected from: 1) H, 2) (C═O) 3) (C═O) 4) (C═O) 5) (C═O) 6) CO 7) C 8) (C═O) 9) (C═O) 10) SO 11) SO said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 5 ; or R 2 and R 2' are combined to form —(CH 2 ) u — wherein one of the carbon atoms is optionally replaced by a moiety selected from O, S(O) m , —NC(O)—, and —N(R b )—, and wherein the ring formed when R 2 and R 2 ′ are combined is optionally substituted with one, two or three substituents selected from R 5 ; R 3 and R 3 ′ are independently selected from: 1) H, 2) (C═O) 3) (C═O) 4) (C═O) 5) (C═O) 6) CO 7) C 8) (C═O) 9) (C═O) 10) SO 11) SO said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more sub stituents selected from R 5 ; or R 3 and R 3 ′ along with the nitrogen to which they are attached are combined to form ring which is a 5-12 membered nitrogen-containing heterocycle, which is optionally substituted with from one to six R 5 groups and which optionally incoporates from one to two additional heteroatoms, selected from N, O and S in the heterocycle ring; R 4 is independently selected from: 1) (C═O) 2) (C═O) 3) (C═O) 4) (C═O) 5) CO 6) halo, 7) OH, 8) O 9) (C═O) 10) CN, 11) (C═O) 12) (C═O) 13) SO 14) SO said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 5 ; R 5 is: 1) (C═O) 2) (C═O) 3) C 4) C 5) (C═O) 6) CO 7) halo, 8) CN, 9) OH, 10) O 11) O 12) oxo, 13) CHO, 14) (N═O)R 15) (C═O) said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6 ; R 6 is selected from: 1) (C═O) 2) O 3) (C 4) oxo, 5) OH, 6) halo, 7) CN, 8) (C═O) 9) (C═O) 10) (C═O) 11) (C═O) 12) (C═) 13) (C═) 14) C(O)R 15) (C 16) C(O)H, 17) (C 18) C(O)N(R said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b )2; R 7 and R 8 are independently selected from: 1) H, 2) (C═O)O 3) (C═O)O 4) (C═O)O 5) (C═O)O 6) C 7) aryl, 8) C 9) C 10) heterocyclyl, 11) C 12) SO 13) (C═O)NR said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 6 , or R 7 and R 8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 5-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 6 ; R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and R b is H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) 2 R a .