Patent ID: 6100282
Filing Date: 2000-08-08
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound having the formula: ##STR62## wherein R.sup.1 is ##STR63## R.sup.2 is ##STR64## R.sup.3 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, carboxy, alkyl-O--CO--, or aralkyl-O--CO--;R.sup.7 and R.sup.8 are each independently hydrogen, alkyl, cycloalkyl, or aralkyl, or R.sup.7 and R.sup.8 together with the N atoms to which they are attached form a 5- to 8-membered heterocyclic ring that is either unsubstituted or substituted with alkyl;R.sup.9 is hydrogen, alkyl, or cycloalkyl;R.sup.10 is aryl, aralkyl, heterocyclyl, heterocyclylalkyl, hydroxy, hydrogen, or alkyl, or R.sup.10 is carboxy, carboxyalkyl, alkyl-O--CO--, aralkyl-O--CO--, alkyl-CO--, aralkyl-CO--, heteroarylalkyl-CO--, alkylsulphonyl, arylsulphonyl or heteroarylsulphonyl and i is zero, or R.sup.10 is an .beta.-amino acid bonded via the amino group and l is zero and k is 1;A is carbonyl or sulphonyl;B is hydrogen, alkyl, or cycloalkyl;a is an integer from 0 to 2 but not being zero when R.sup.1 is --NH.sub.2 ; c, d, f, g, k, l and m are each independently an integer from 0 to 1, whereby c, f and g are not simultaneously 0 and whereby m is not 0 when f or g is 1; i is an integer from 0 to 1, whereby k and l are also 0 when i is 0; e is an integer from 0 to 3; h is an integer from 0 to 5; j is an integer from 0 to 2; and the sum of e, h and j is an integer from 2 to 7;and the pharmaceutically usable salts and esters thereof.