Patent ID: 8106209
Filing Date: 2012-01-31
Classification: A61P,C07D

Abstract:
1. A compound of Formula II-A or Formula II-B, or pharmaceutically acceptable salt, wherein: A is a group of the formula: R R R R (a) halogen, hydroxyl, amino, cyano, —COOH, —CONH (b) C R is a group of the formula: where R R R R R R R n is an integer from 1 to 4, independently chosen at each occurrence; m is an integer from 0 to 4, independently chosen at each occurrence; [G] is oxygen or absent; T is O or S; Aryl is phenyl or pyridyl; each of which is substituted with 0 to 3 substituents independently chosen from halogen, hydroxyl, amino, cyano, oxo, C Het is a 5- to 6-membered heteroaryl or unsaturated heterocylic group containing 1 to 4 heteroatoms independently chosen from O, S, and N, remaining ring atoms are carbon, and Het is substituted with 0 to 3 substituents independently chosen from halogen, hydroxyl, amino, cyano, oxo, C [U] is absent or is phenyl, pyridyl, thienyl, C wherein the compound is not 2-amino-N-(5-fluoro-4-(pyridin-3-yl)thiazol-2-yl)-3-methyl-N-(4-octyl-3-(trifluoromethyl)phenyl)butanamide; 2-(4-((5-fluoro-4-(pyridin-3-yl)thiazol-2-yl)(4-octyl-3-(trifluoromethyl)phenyl)amino)-2-methyl-4-oxobutan-2-yl)-3,5-dimethylphenyl dihydrogen phosphate; 2-(phosphonooxy)ethyl 5-fluoro-4-(pyridin-3-yl)thiazol-2-yl(4-octyl-3-(trifluoromethyl)phenyl)carbamate; 2-((5-fluoro-4-(pyridin-3-yl)thiazol-2-yl)(4-octyl-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl dihydrogen phosphate; 4-((5-fluoro-4-(pyridin-3-yl)thiazol-2-yl)(4-octyl-3-(trifluoromethyl)phenyl)amino)-4-oxobutyl dihydrogen phosphate; ((5-fluoro-4-(pyridin-3-yl)thiazol-2-yl)(4-octyl-3-(trifluoromethyl)phenyl)carbamoyl-oxy)methyl 2-amino-3-methylbutanoate; or phosphonooxymethyl 5-fluoro-4-(pyridin-3-yl)thiazol-2-yl(4-octyl-3-(trifluoromethyl)phenyl)carbamate.