Patent ID: 8008478
Filing Date: 2011-08-30
Classification: C07D

Abstract:
1. A process for preparation of cefixime of formula (I) which comprises: (i) reaction of 7-β-(4-chloro-2-alkoxycarbonyl methoxyimino-3-oxobutyromido)-3-cephem-4-carboxylic acid of formula V wherein R represents (C (ii) carbon treatment to the reaction mixture in presence of sodium dithionite or ethylenediaminetetraacetic acid (EDTA) followed by filtration, (iii) acidification of the filtrate obtained above in step (ii) to pH 2.0 to 3.0 with acid at 50-80° C. to give cefixime ester of formula IV wherein R (iv) alkaline hydrolysis of cefixime ester of formula (IV) wherein R (v) precipitation of cefixime (I) by adding solvent, the solvent comprising a ketone, followed by acidification to pH 2.0 to 3, and (vi) isolation of solid.