Patent ID: 9126995
Filing Date: 2015-09-08
Classification: B01J,C07B,C07D

Abstract:
1. A method for catalytic asymmetric synthesis of an optically active isoxazoline compound, the method comprising: causing an α,β-unsaturated carbonyl compound of Formula (1): where R each of A each of A X R Y each of A Y R R R R R D-1 to D-50 are heteroaromatic rings of structural formulae below: Z is a halogen atom, cyano, nitro, amino, C E-1 to E-21 are heterocycles of structural formulae below: Z Z R R R R R R R R R R R R R R R R R R p1 is an integer of 1 to 5; p2 is an integer of 0 to 4; p3 is an integer of 0 to 3; p4 is an integer of 0 to 2; p5 is an integer of 0 or 1; q2 is an integer of 0 to 5; q3 is an integer of 0 to 7; q4 is an integer of 0 to 9; t is an integer of 0 or 1; L is —C(R R R r is an integer of 0 to 2, to react with a hydroxyl amine in a solvent, in the presence of a base and a chiral phase transfer catalyst of Formulae (7), (8), (9), or (10): where X the optically active isoxazoline compound is represented by Formula (6): where each of R