Patent ID: 7348003
Filing Date: 2008-03-25
Classification: A61K,C07K

Abstract:
1. A method of treating a TR4 expressing cancer comprising administering to an animal an isolated antibody or fragment thereof comprising the amino acid sequence selected from the group consisting of: (a) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:42; (b) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:43; and (c) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:47; wherein said antibody or fragment thereof immunospecifically binds a TR4 protein selected from the group consisting of: (i) a polypeptide having the amino acid sequence of any one of amino acid residues 1 to 468 of SEQ ID NO:1, amino acid residues 24 to 468 of SEQ ID NO:1, amino acid residues 24 to 238 of SEQ ID NO:1, and amino acid residues 109 to 240 of SEQ ID NO:1; (ii) a multimer of the polypeptide of (i); (iii) the polypeptide of (i) expressed on the surface of a cell; and (iv) the multimer of (ii) expressed on the surface of a cell; or a composition containing said antibody or fragment thereof.