Patent ID: 6838559
Filing Date: 2005-01-04
Classification: A61K,A61P,C07D

Abstract:
1. A compound selected from (i) 2-[[6-[(1,3-Benzodioxol-5-ylmethyl)amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[(3-pyridinylmethyl)amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[(3,4,5-trimethoxyphenyl)methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[[4-(methylsulfonyl)phenyl]methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-[[(1R)-1-phenylethyl]amino]-7-ethyl-7H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-[[(1S)-1-phenylethyl]amino]-7-ethyl-7H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(1R)-2,3-Dihydro-1H-inden-1-yl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; -[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[[4-(Aminosulfonyl)phenyl]methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[(2,3,4-trimethoxyphenyl)methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[(4-methoxy-3-methylphenyl)methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(4-Cyanophenyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[[4-(Acetylamino)phenyl]methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[(3-quinolinylmethyl)amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[[4-(methylthio)phenyl]methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[[4-(methoxycarbonyl)phenyl]methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(1,3-Benzodioxol-4-yl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(2,3-Dihydro-5-benzofuranyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(3-Chloro-4-methylphenyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(3,5-Dimethylphenyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(2,3-Dihydro-6-methoxy-1H-inden-1-yl)amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(2,3-Dihydro-5-methoxy-1H-inden-1-yl)amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(2,3-Dihydro-5,6-dimethoxy-1H-inden-1-yl)amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(3,4-Dimethoxyphenyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[7-Ethyl-6-[(1,2,3,4-tetrahydro-6,7-dimethoxy-1-naphthalenyl)amino]-7H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[[4-(3,4-Dimethoxyphenyl)methyl]amino]-7-ethyl-7H-purin-2-yl]amino]-4-methyl-N-phenyl-5-thiazolecarboxamide; 2-[[6-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-9-ethyl-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[[4-(Aminosulfonyl)phenyl]methyl]amino]-9-ethyl-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[(4-Carboxyphenyl)methyl]amino]-9-ethyl-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[9-Ethyl-6-[[(4-methoxyphenyl)methyl]thio]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[9-Ethyl-6-[[4-(methylsulfonyl)phenyl]methoxy]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[9-Ethyl-6-[[4-(methylsulfinyl)phenyl]methoxy]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[9-Ethyl-6-[[[4-(methylsulfonyl)phenyl]sulfonyl]amino]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; 2-[[6-[[(3,4-Dimethoxyphenyl)methyl]amino]-9-ethyl-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester, trifluoroacetate (1:1); 4-Methyl-2-[[6-(methylamino)-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[[[4-(methylsulfonyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-(4-tert-butyloxycarbonyl-1-piperazinyl)-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-(1-piperazinyl)-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[2-(Dimethylamino)ethyl]amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-(4-morpholinyl)-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[(3-pyridinylmethyl)amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[2-(1,1-Dimethylethoxy)-2-oxoethyl]amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[[3-(4-morpholinyl)propyl]amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-(4-methyl-1-piperazinyl)-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-[[2-(1-methyl-2-pyrrolidinyl)ethyl]amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-[[2-(1-methyl-1H-imidazol-5-yl)ethyl]amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(2S)-2-(Hydroxymethyl)-1-pyrrolidinyl]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[6-[methyl(1-methyl-4-piperidinyl)amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[[2-(2-pyridinyl)ethyl]amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[(2-pyridinylmethyl)amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 4-Methyl-2-[[9-[[4-(methylsulfonyl)phenyl]methyl]-6-[(4-pyridinylmethyl)amino]-9H-purin-2-yl]amino]-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[3-(Hydroxymethyl)-1-piperidinyl]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl est; 2-[[6-(Dimethylamino)-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[6-[(2-Methoxyethyl)amino]-9-[[4-(methylsulfonyl)phenyl]methyl]-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester; 2-[[9-[(3,4-Dimethoxyphenyl)methyl]-6-(4-morpholinyl)-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; 2-[[9-[(pyridin-3-yl)methyl]-6-(4-morpholinyl)-9H-purin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; and N-[4-(5-Methyl-2-pyrimidinyl)phenyl]-6-(4-morpholinyl)-9-(2-pyridinylmethyl)-9H-purin-2-amine; or (ii) enantiomers, diastereomers and salts of (i) thereof.