Patent ID: 8999921
Filing Date: 2015-04-07
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A polypeptide variant of native vimentin comprising SEQ ID NO: 1, wherein said polypeptide variant comprises an amino acid sequence wherein at least one amino acid residue at position 16, 17, 19, 41, 58, 59, 60, 68, 76, 140, 142, 147, 363, 406 or 452 in said SEQ ID NO: 1 is substituted by arginine and wherein optionally (a) at least one amino acid residue at positions 3, 20, 33, 36, 37, 94, 165, 361, 399 or 426 in said SEQ ID NO: 1 is substituted by leucine; (b) at least one amino acid residue at positions 21, 41, 43, 50, 54, 62, 64 or 89 in said SEQ ID NO: 1 is substituted by proline; (c) at least one amino acid residue at positions 24, 35 or 99 in said SEQ ID NO: 1 is substituted by threonine; or (d) at least one amino acid residue at positions 25, 39, 42, 49, 55 or 67 in said SEQ ID NO: 1 is substituted by tyrosine.