Patent ID: 6086881
Filing Date: 2000-07-11
Classification: A61K,A61P,C07K,C12N

Abstract:
A spatially aligned conjugated composition suitable as an immunogen to be administered to a living subject for inducing an immune response against a prechosen infectious agent, said conjugated composition comprising:at least one chemically modified substance wherein said chemical modification provides said substance with at least one reactive entity and a fixed spatial orientation for forming a thioether bond and wherein said substance is selected from the group consisting of haptens and antigens immunologically representative of the prechosen infectious agent;a plurality of chemically substituted metallic oxide particles wherein said chemical substitution provides said particles with at least one corresponding reactive moiety for forming a thioether bond and wherein said metallic oxide particles have a diameter size ranging from about 10-10,000 nanometers; andat least one thioether bond joining said modified substance in a controlled orientation to said nanometer-sized substituted metallic oxide particles to form a plurality of spatially aligned conjugates.