Patent ID: 8609592
Filing Date: 2013-12-17
Classification: A01N,C07D

Abstract:
1. A compound selected from the group consisting of: 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid methyl ester (Compound 1) 6-Amino-2-(4-chlorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 2) 6-Amino-2-(4-chloro-2-fluoro-5-methylphenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 3) 6-Amino-2-(4-chloro-2,5-difluorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 4) 6-Amino-2-(4-chloro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 5) 6-Amino-2-(4-chloro-2,3-difluorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 6) 6-Amino-2-(4-chloro-3-dimethylamino-2-fluorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 7) 6-Amino-2-[4-chloro-3-(1-fluoroethyl)phenyl]-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 8) 6-Amino-2-(4-chloro-3-fluorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 9) 6-Amino-2-(2-fluoro-4-methylphenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 10) 6-Amino-5-methoxy-2-(4-trifluoromethylphenyl)pyrimidine-4-carboxylic acid ethyl ester (Compound 11) 6-Amino-2-benzo[1,3]dioxol-5-yl-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 12) 6-Amino-2-(4-chloro-2-fluorophenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 13) 6-Amino-2-[4-chloro-2-fluoro-3-(1-fluoroethyl)phenyl]-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 14) 6-Amino-5-methoxy-2-p-tolylpyrimidine-4-carboxylic acid ethyl ester (Compound 15) 6-Amino-2-(4-chloro-2-fluoro-5-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid ethyl ester (Compound 16) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-dimethylaminopyrimidine-4-carboxylic acid methyl ester (Compound 17) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-ethoxy-pyrimidine-4-carboxylic acid (Compound 18) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methylsulfanylpyrimidine-4-carboxylic acid methyl ester (Compound 19) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-(2,2,2-trifluoroethoxy)pyrimidine-4-carboxylic acid methyl ester (Compound 20) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methylsulfanyl-pyrimidine-4-carboxylic acid (Compound 21) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 22) 6-Amino-2-(4-chlorophenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 23) 6-Amino-2-(4-chloro-2-fluoro-5-methylphenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 24) 6-Amino-2-(4-chloro-2,5-difluorophenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 25): 6-Amino-2-(4-chloro-2,3-difluorophenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 26) 6-Amino-2-(4-chloro-3-fluorophenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 27) 6-Amino-2-(2-fluoro-4-methylphenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 28) 6-Amino-5-methoxy-2-(4-trifluoromethylphenyl)pyrimidine-4-carboxylic acid (Compound 29) 6-Amino-2-benzo[1,3]dioxol-5-yl-5-methoxypyrimidine-4-carboxylic acid (Compound 30) 6-Amino-2-(4-chloro-2-fluorophenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 31) 6-Amino-5-methoxy-2-p-tolylpyrimidine-4-carboxylic acid (Compound 32) 6-Amino-2-(4-chloro-2-fluoro-5-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid (Compound 33) 6-Amino-2-[4-chloro-2-fluoro-3-(1-fluoroethyl)phenyl]-5-methoxypyrimidine-4-carboxylic acid (Compound 34) 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methylaminopyrimidine-4-carboxylic acid (Compound 35)