Patent ID: 7087086
Filing Date: 2006-08-08
Classification: A61L

Abstract:
1. A method of modifying a ceramic-coated implantable article, which method comprises: (a) providing an implantable article comprising a biocompatible substrate with a bioactive ceramic coating on at least a portion of the surface of the biocompatible substrate, (b) incubating at least a portion of the bioactive ceramic coating with a composition comprising (i) a biological agent, (ii) calcium ions in a concentration of about 0.01 mM to about 1 mM, (iii) phosphate ions in a concentration of about 0.01 mM to about 1 mM, and (iv) a liquid carrier, wherein the pH of the composition is between about 3.5 to about 9, and (c) removing the liquid carrier from the bioactive ceramic coating to yield a modified implantable article with a bioactive ceramic coating into which the biological agent is incorporated.