Patent ID: 7723355
Filing Date: 2010-05-25
Classification: A61P,C07D

Abstract:
1. A compound of the structure wherein b is a single or double bond; n is 1 or 2; R X is selected from the group consisting of C═O, C═S, CHR R Z is selected from the group consisting of C═O, C═S, and CHR R A is selected from the group consisting of hydrogen (H), alkyl, alkenyl, alkynyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl, heteroaryl, cycloheteroalkyl, O—R 1 , cyano, amino, —C(O)—OH, —C(O)—NR 6 R 7 , —C(O)—OR 6 , S(O) m —R 6 , S(O) 2 NR 6 R 7 , —NR 6 R 7 , —NR 6 —C(O)R 7 and —NR 6 —SO 2 R 7 , wherein any such functional group may optionally be substituted with one to three or more substituents selected from the group consisting of hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, aryl, haloalkoxy, polyhaloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, bicycloalkyl, cycloalkylalkyl, polycycloalkyl, heteroarylamino, arylamino, cycloheteroalkyl, heteroaryl, cycloheteroalkylalkyl, hydroxy, hydroxyalkyl, nitro, cyano, amino, substituted amino, alkylamino, dialkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, arylalkylthio, aminocarbonyl, alkynylaminocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, aminosulfonyl, alkylsulfinyl, sulfonamido and sulfonyl; m is 0, 1 or 2; R R Y is selected from the group consisting of aryl and heteroaryl, wherein said aryl or heteroaryl may optionally be substituted with one to three or more substituents selected from the group consisting of hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, haloalkoxy, polyhaloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, polycycloalkyl, heteroarylamino, arylamino, cycloheteroalkyl, cycloheteroalkylalkyl, hydroxy, hydroxyalkyl, nitro, cyano, amino, substituted amino, alkylamino, dialkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, aminocarbonyl, alkynylaminocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, aminosulfonyl, alkylsulfinyl, sulfonamido and sulfonyl; or a pharmaceutically acceptable salt thereof, and all stereoisomers thereof.