Patent ID: 6015806
Filing Date: 2000-01-18
Classification: A61K

Abstract:
A method of treating or reducing the risk of acquiring a condition selected from the group consisting of acne, seborrhea, comprising administering to a patient in need of such treatment or reduction a therapeutically effective amount of an antiandrogenic compound of the molecular formula: ##STR29## wherein the dotted lines are optional .pi. bonds; wherein R.sup.4 is --H or --CH.sub.3 ;wherein R.sup.6 is --H, --CH.sub.3, --CH.sub.2 CH.sub.3 or halogen, but is hydrogen when the optional .pi. bond at 6,7 is present;and wherein R.sub.17.alpha. is selected from the group consisting of:A) a halogenated unsaturated hydrocarbon moiety having at least one halogen atom that is separated from said D-ring by at least 3 intervening atoms, and having no carbon atom separated from said D-ring by more than four intervening atoms; andB) a haloalkyl moiety having at least one halogen atom separated from said D-ring by at least three intervening atoms and having no carbon atom separated from said D-ring by more than 4 intervening atoms;provided that R.sup.17.alpha. is not ##STR30## CH.sub.2 X when R.sup.4 or R.sup.6 are both hydrogen (x being halogen).