Patent ID: 6440955
Filing Date: 2002-08-27
Classification: A61K,A61P,C07D,C07K,C40B,G01N

Abstract:
A method for treating an inflammatory or cell adhesion-mediated disease comprising administering to a warm-blooded animal in need thereof an effective amount of a composition comprising a compound having the structure: or a pharmaceutically acceptable salts or stereoisomers thereof, whereinA is â€”(CR5R5a)nâ€” where n is 1, 2 or 3; R2, R3 and R5 are, at each occurrence, the same or different and independently an amino acid side chain moiety or amino acid side chain derivative, a peptide or peptide derivative, a linker or a solid support; R2a, R3a and R5a are, at each occurrence, the same or different and independently hydrogen, hydroxy, â€”COOH, â€”CONH2, â€”R6, â€”OR6, â€”COOR6, â€”COR6 or â€”CONHR6, where R6 is lower alkyl optionally substituted with halogen or hydroxy; and R1 and R4 represent the remainder of the molecule, with the proviso that when R1 is â€”C(&boxH;O)OMe and R4 is benzyl, R2 is not isopropyl when R3 is methyl and R2 is not methyl when R3 is isopropyl and a pharmaceutically acceptable carrier.