Patent ID: 7105663
Filing Date: 2006-09-12
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of formula I: wherein each of R R R each of R R X represents a group CR each of R Y represents an oxygen atom or a group CHNO n is an integer from 2 to 4; or a salt thereof, the process comprising: wherein R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , R 9 , X and n are as defined for formula I, with an amine-reactive compound selected from the group consisting of (i) a cyanate salt, (ii) an isocyanate of the formula R 11 —NCO wherein R 11 is as defined for formula I, (iii) an N—C 1-3 alkyl- or N—C 3-6 cycloalkyl-1-methylthio)-2-nitroethenamine of the formula CH 3 SC(═CHNO 2 )NR 10 R 11 wherein R 10 and R 11 are as defined for formula I, (iv) a compound of the formula CH 3 SC(═NH)NR 10 R 11 or a salt thereof wherein R 10 and R 11 are as defined for formula I, (v) a compound of the formula CH 3 SC(═NCN)NR 10 R 11 or a salt thereof wherein R 10 and R 11 are as defined for formula I, and (vi) 2-methyl-1-nitro-2-isothiourea, to form a compound of formula I; or wherein R 1 , R 2 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , Y and n are as defined for formula I.