Patent ID: 7115651
Filing Date: 2006-10-03
Classification: A61P,C07D

Abstract:
1. A compound having the structure: wherein the dotted line - - - represents an optional bond, such that either a single or a double bond is present; R R R R Z is O; X is O; A and B together represent —CHR 5 —CHR 6 —, —CR 5 ═CR 6 —, wherein R 5 and R 6 are each independently hydrogen, halogen, cyano, —OR J , —N(R J ) 2 , —SR J , —O(C═O)R J , —O(S═O)R J , —N(R J )(C═O)(R J ), —C(═O)R J , —C(═O)OR J , —CON(R J ) 2 , —OCO 2 R J , —OSO 2 R J , or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl moiety, wherein each occurrence of R J is independently hydrogen, or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl moiety, and wherein R 7 is hydrogen, —OR K , —SR K , —C(O)OR K , —S(O) 2 R K , —O(C═O)R K , —N(R K )(C═O)(R K ), —C(O)R K , —C(O)OR K , —CON(R K ) 2 , —OCO 2 R K , or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl moiety, wherein each occurrence of R K is independently hydrogen, or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl moiety, or when A and B together represent —CHR 5 —CHR 6 —, R 5 and R 6 taken together represent a substituted or unsubstituted 3–7 membered aliphatic, heteroaliphatic, aryl or heteroaryl ring, D and E together represent —CHR G and J together represent —CHR K and L together represent C═O, C═S, CH—CH whereby each of the foregoing aliphatic and heteroaliphatic moieties may independently be substituted or unsubstituted, cyclic or acyclic, or branched or unbranched, and each aryl, heteroaryl, alkylaryl, and alkylheteroaryl moiety may be substituted or unsubstituted; wherein one or any two of R pharmaceutically acceptable derivatives thereof, with the proviso that: (1) if A and B together are and R 5 and R 6 are each hydrogen; if D and E together are —CH═CH—; if G and J together are —CH═CH—; if K and L together are C═O; if R 1 is hydrogen or Cl; and if R 3 is hydrogen, then R (2) if A and B together are and R 5 and R 6 are each hydrogen; if D and E together are —CH 2 —CH 2 —; if G and J together are —CH 2 —CH 2 — or —CH═CH—; if K and L together are C═O; if R 1 is hydrogen or Cl; and if R 3 is hydrogen, then R (3) if R or if A and B together are —CHR 5 —CHR 6 — and R 6 is hydrogen or halogen or —OH or —OCH 3 and R 5 is OR J , wherein R J is hydrogen, benzoyl, alkanoyl, or alkenoyl, or R 5 is —O(S═O)R J , wherein R J is a second compound of formula (I) linked via an oxygen atom present at R 5 in the second compound of formula (I), and wherein R 6 of the second compound of formula (I) is halogen; Z of the second compound of formula (I) is O; X of the second compound of formula (I) is O, R 1 of the second compound of formula (I) is Cl; R 2 of the second compound of formula (I) is OR B and R B is hydrogen, alkanoyl, alkenoyl, tert-butyl dimethylsilyl or tert-butyldiphenylsilyl; R 3 of the second compound of formula (I) is hydrogen; R 4 of the second compound of formula (I) is OR D and R D is hydrogen, alkanoyl, alkenoyl, tert-butyldimethylsilyl, or tert-butyldiphenylsilyl; then K and L together are not C═O or C═N—O—R except that K and L together can be C═N—O—R (4) if D and E together are —CH then A and B together are not —CH (5) if D and E together are —CH then A and B together are not —CH (6) the compound is other than: