Patent ID: 7935710
Filing Date: 2011-05-03
Classification: A61K,A61P

Abstract:
1. A method for reducing transmission of or infection with HIV in a patient uninfected with HIV, comprising the step of: administering to said patient uninfected with HIV a medicament comprising: a compound having the formula (I) or (II); wherein the transmission of or infection with HIV is via sexual intercourse or related intimate contact between partners; and wherein a compound of formula (I) corresponds to a N-oxide, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein Y is CR A is CH; n is 1; Q is —NR R R R R R L is —X R X Alk is C L may also be selected from the group consisting of C aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from the group consisting of halo, C Het is an aliphatic or aromatic heterocyclic radical; wherein said aliphatic heterocyclic radical is selected from the group consisting of pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl and tetrahydrothienyl wherein each of said aliphatic heterocyclic radical may optionally be substituted with an oxo group; and wherein said aromatic heterocyclic radical is selected from the group consisting of pyrrolyl, furanyl, thienyl, pyridyl, pyrimidinyl, pyrazinyl and pyridazinyl wherein each of said aromatic heterocyclic radical may optionally be substituted with hydroxy; and, wherein a compound of formula (II) corresponds to a N-oxide, a pharmaceutically acceptable addition salt, quaternary amine or a stereochemically isomeric form thereof, wherein -b q is 0; R R each R wherein each A independently is N, CH or CR B is NH, O, S or NR p is 1 or 2; R L is C C indolyl or isoindolyl, each optionally substituted with one, two, three or four substituents each independently selected from the group consisting of halo, C phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein each of said aromatic rings may optionally be substituted with one, two, three, four or five substituents each independently selected from the substituents defined in R L is —X—R R X is —NR Q represents hydrogen, C R R Y represents hydroxy, halo, C aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from the group consisting of halo, C Het is an aliphatic or aromatic heterocyclic radical; wherein said aliphatic heterocyclic radical is selected from pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl or tetrahydrothienyl wherein each of said aliphatic heterocyclic radical may optionally be substituted with an oxo group; and wherein said aromatic heterocyclic radical is selected from the group consisting of pyrrolyl, furanyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl wherein each of said aromatic heterocyclic radical may optionally be substituted with hydroxyl.