Patent ID: 6100259
Filing Date: 2000-08-08
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR15## wherein: R.sub.1 is OCH.sub.3, Br, isopropyl, or Ar;R.sub.2 is H, OH, C.sub.1-5 alkoxy, C.sub.1-5 alkyl, N(R.sub.5).sub.2, NO.sub.2, Br, F, I, Cl, CF.sub.3, or X(C(R.sub.5).sub.2)OR.sub.5 ;R.sub.3 is hydrogen, (CH.sub.2).sub.n XR.sub.5, C(O)R.sub.5, CO.sub.2 R.sub.5, CON(R.sub.5).sub.2, oxazolinyl, oxazolyl, thiazolyl, pyrazolyl, triazolyl, imidazolyl, tetrazolyl, imidazolinyl, thiazolinyl, isoxazolyl, oxadiazolyl, or thiadiazolyl, each of these heterocyclic rings being unsubstituted or substituted by one or two C.sub.1-3 alkyl or fluoroalkyl groups;R.sub.4 is morpholinyl, piperazinyl or piperidinyl, each moiety being unsubstituted or substituted by one or two C.sub.1-5 alkyl, OH, NO.sub.2 or N(R.sub.5).sub.2 groups;R.sub.5 is hydrogen or C.sub.1-8 alkyl;X is O or NR.sub.5 ;Ar is phenyl, anthracenyl, naphthyl, indolyl, pyridinyl, thiophenyl, thiazolyl, isothiazolyl, triazolyl, tetrazolyl, imidazolyl, oxadiazolyl, pyrrolyl or pyrimidinyl; each moiety being unsubstituted or substituted by one or two Z groups;Z is H, OH, CO.sub.2 R.sub.5, C.sub.1-10 alkoxy, C.sub.1-5 alkyl, N(R.sub.5).sub.2, NO.sub.2, Br, F, I, Cl, CF.sub.3, or X(CH.sub.2).sub.n OR.sub.5 ; andn is 1 to 6; andpharmaceutically acceptable salts thereof;provided that when n is 1, R.sub.5 is not hydrogen in X(CH.sub.2).sub.n OR.sub.5.