Patent ID: 8907053
Filing Date: 2014-12-09
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A compound of formula (I) or pharmaceutically acceptable salt thereof; wherein; the compound comprises at least 5 amino acids, A is an amino acid sequence SNTSESF (SEQ ID NO: 4); B is an amino acid sequence SNTSESF (SEQ ID NO: 4); Z is (i) from one to four peptide sequences arranged in any order each being of from three amino acids up to the full length of a mammalian PD1 ectodomain fragment selected from BC loop, D strand, FG loop, G strand, C strand, F strand, C′ strand, C″ strand, C″-D loop, C′ strand to C′—C″ loop, C′ strand to C″ strand or D strand to DE loop; (ii) G-L-Z′ (iii) from one to four peptide sequences arranged in any order each being of from three amino acids up to the full length of a mammalian PD1 ectodomain fragment selected from D-strand, FG loop and G strand, wherein two or more amino acids of the peptide sequence combine together to form a lactam bond between any of the two fragments or within the fragment; D is up to two peptide sequences arranged in any order each being of from three amino acids up to the full length of a mammalian PD1 ectodomain fragment selected from BC loop, FG loop, C C′ loop to C′ strand or is absent; E is up to four peptide sequences arranged in any order each being of from three amino acids up to the full length of a mammalian PD1 ectodomain fragment selected from BC loop, D strand, FG loop, C C′ loop to C′ strand, G strand, FG loop to G strand or is absent; X is lysine; X′ is selected from lysine, ornithine, diaminopropionic acid, diaminobutyric acid or olefinic amino acid of formula which is optionally linked with an additional lysine; or X′ is absent; ‘m’ is an integer selected from 1 to 6, both inclusive; R R R