Patent ID: 6172109
Filing Date: 2001-01-09
Classification: A61P,C07C

Abstract:
A method of treating glaucoma and ocular hypertension which comprises administering to the affected eye a therapeutically effective amount of a compound of formula (I): ##STR11##wherein:R.sup.1 =CO.sub.2 R, CONR.sup.4 R.sup.5, CH.sub.2 OR.sup.6, or CH.sub.2 NR.sup.7 R.sup.8 ; wherein:R=H or cationic salt moiety, or CO.sub.2 R=pharmaceutically acceptable ester moiety;R.sup.4, R.sup.5 =same or different=H or alkyl; R.sup.6 =H, acyl, or alkyl;R.sup.7, R.sup.8 =same or different=H, acyl, or alkyl; with the proviso that if one of R.sup.7, R.sup.8 =acyl then the other=H or alkyl;n=0 or 2;R.sup.2, R.sup.3 =same or different=H, alkyl, or acyl;B=H, and OH in either configuration, H and F in either configuration, double bonded O, or OCH.sub.2 CH.sub.2 O;X=(CH.sub.2).sub.q or (CH.sub.2).sub.q O; where q=1-6; andY=C.sub.1-6 alkyl group or phenyl ring optionally substituted with alky, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkyl amino, or hydroxy; orX-Y=(CH.sub.2).sub.p Y.sup.1 ; where p=0-6; and ##STR12##orwherein:W=CH.sub.2, O, S(O).sub.m, NR.sup.9, CH.sub.2 CH.sub.2, CH.dbd.CH, CH.sub.2 O, CH.sub.2 S(O).sub.m, CH.dbd.N, or CHNR.sup.9 ; where m=0-2, and R.sup.9 =H, alkyl, or acyl;Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and--=single or double bond;with the proviso that the following compounds are excluded: [1 S-[l.alpha.(Z),2.beta.(R*),3.alpha.,5.alpha.]]-7-[2-[[3-(3-Chlorophenoxy)- 2-hydroxypropyl]thiol]-3,5-dihydroxycyclopentyl]-5-heptenoic acid and pharmaceutically acceptable esters and salts thereof.