Patent ID: 6166072
Filing Date: 2000-12-26
Classification: C07C

Abstract:
A compound selected from the group consisting of a compound of the formula; ##STR10## wherein; Ar.sup.1 and Ar.sup.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above;wherein any cycloalkyl or aryl substituent is linked to Ar.sup.1 or Ar.sup.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;R.sup.3 is selected from the group consisting of H and aryl, which may be substituted as for Ar.sup.1 ;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, alkyl, alkanoyl, benzoyl and benzyl;R.sup.6 is selected from the group consisting of H and an alkyl group having up to 20 carbon atoms,X is selected from the group consisting of S, SO, SO.sub.2, NR and CRR', where R and R' are independently selected from the group consisting of H, alkyl, aryl and aralkyl;Y is a methylene or ethylene linking element, optionally substituted with one or more substituents independently selected from the group consisting of alkyl and phenyl;with the following provisos:when Ar.sup.1 and Ar.sup.2 are phenyl rings, R.sup.3 is H or a phenyl ring, and R.sup.4 -R.sup.6 are each H at least one of groups Ar.sup.1 and Ar.sup.2 must be substituted,when X.dbd.S and R.sup.4 and R.sup.5 are each H, and R.sup.6 is H or alkyl:(i) Ar.sup.2 cannot be unsubstituted phenyl when Ar.sup.1 is 4-monosubstituted phenyl,(ii) Ar.sup.1 and Ar.sup.2 cannot both be 4-methoxyphenyl when R.sup.3 is H or unsubstituted phenyl,(iii) Ar.sup.1, Ar.sup.2 and R.sup.3 cannot all be 3-fluorophenyl or 4-methoxyphenyl,(iv) Ar.sup.1 and Ar.sup.2 cannot both be 4-hydroxymethylphenyl when R.sup.3 is unsubstituted phenyl,and a stereoisomer, salt, solvate and hydrate thereof.