Patent ID: 9095653
Filing Date: 2015-08-04
Classification: A61M,G16B,G16H

Abstract:
1. A method of administering a medicament having a narrow therapeutic window into a body of a patient in need of treatment with said medicament as a function of time with the aid of a computer-controlled dosage device, said method comprising the following steps: a) inputting an indication- and substance-dependent predetermined target profile, which indicates a desired concentration-time profile or a desired effect-time profile and a dosage time profile which describes the dose administered as a function of time into a physiology-based and/or pharmacodynamic computer model module, b) physiology-based pharmacokinetic and/or pharmacodynamic simulating with a time-variable application profile while taking into account individual anatomical, physiological and/or genetic parameters of the body to be treated and substance-specific input parameters of the medicament to be administered within the physiology-based and/or pharmacodynamic computer model module and outputting a simulated time profile, c) iterative numerical adapting of the dosage time profile until the simulated time profile matches the predetermined target profile to yield an adapted dosage time profile, and d) outputting of the adapted dosage time profile of c) to control the dosage device according to the adapted dosage time profile, and administering said medicament having said narrow therapeutic window to said patient using said dosage device controlled by said adapted dosage time profile.