Patent ID: 6747008
Filing Date: 2004-06-08
Classification: A61K

Abstract:
A method for treating alopecia, comprising administering to a subject in need thereof at least one active agent comprising a sequence of at least seven contiguous amino acids of groups R1-R8 in the sequence of general formula IR1â€”R2â€”R3â€”R4â€”R5â€”R6â€”R7â€”R8 wherein R1 is selected from the group consisting of H, Asp, Glu, Asn, Acpc (1-aminocyclopentane carboxylic acid), Ala, Me2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2) and Suc,R2 is selected from the group consisting of Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys; R3 is selected from the group consisting of Val, Ala, Leu, Lys, norLeu, Ile, Gly, Pro, Aib, Acpc and Tyr; R4 is selected from the group consisting of Tyr, Tyr(PO3)2, Thr, Ser, Ala, homoSer and azaTyr; R5 is selected from the group consisting of Ile, Ala, Leu, norLeu, Val and Gly; R6 is selected from the group consisting of His, Arg or 6-NH2-Phe; R7 is selected from the group consisting of Pro or Ala; and R8 is selected from the group consisting of Phe, Phe(Br), Ile and Tyr, excluding sequences including R4 as a terminal Tyr group.