Patent ID: 6696457
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound selected from:[10R,4bR-(4b beta,9a beta)]-7-(N,N-diisopropyl)aminocarbonyl-8-methyl4b,5,9,9a, 10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-benzyl-N-isopropyl)aminocarbonyl]-8-methyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro-[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-(N,N-diethyl)aminocarbonyl-8-methyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bS-(4b beta,9a beta)]-7-(N-isopropyl-N-benzyl)aminocarbonyl-8-methyl-4b,5,9,9a,10,11-hexahydro-(6H)-10-,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-(N-benzyl-N-ethyl)aminocarbonyl-8-methyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-( 1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl-8-methyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-isobutylcarbonyl-8-methyl-4b,5,9,9a, 10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-phenyl-N-ethyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bS-(4b beta,9a beta)]-7-(N-ethyl-N-phenyl)aminocarbonyl-8-methyl-4b,5,9,9a,10,11-hexahydro-(6H)-10,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bS-(4b beta,9a beta)]-7-(N-benzyl-N-isopropyl)aminocarbonyl-6,8-dimethyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bS-(4b beta,9a beta)]-7-(N-ethyl-N-benzyl)aminocarbonyl-6,8-dimethyl-4b,5,9,9a,10,11-hexahydro-(6H)-10-,4b-(iminoethano)phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-N-(cis-2,6-dimethyl)piperidinylcarbonyl-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-benzyl-N-ethyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-methoxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-(4-trifluoromethyl)phenylmethyl-N-isopropyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-(3-fluoro)phenylmethyl-N-isopropyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-(4-bromo)phenylmethyl-N-isopropyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; [10R,4bR-(4b beta,9a beta)]-7-[(N-(4-isopropyl)phenylmethyl-N-isopropyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; and [10R,4bR-(4b beta,9a beta)]-7-[(N-benzyl-N-cyclohexyl)aminocarbonyl]-4b,5,9,9a,10,11-hexahydro-9a-hydroxy-(6H)-8-methyl-10,4b-(iminoethano)-phenanthro[3,2-b]pyrrole; or a pharmaceutically acceptable salt or solvate of any one thereof.