Patent ID: 8017772
Filing Date: 2011-09-13
Classification: A61P,C07D

Abstract:
1. A method of treating or inhibiting a condition selected from the group consisting of pain mediated through the KCNQ2/3 K + channel, epilepsy, migraine and anxiety in a patient in need thereof, said method comprising administering to said patient a pharmacologically effective amount of a substituted tetrahydropyrrolopyrazine compound corresponding to formula I: wherein R R R R R R wherein: if an alkyl group, heterocyclyl group or cycloalkyl group is mono- or poly-substituted, the substituents are independently selected from the group consisting of F, Cl, Br, I, —CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, C 1-6 -alkyl, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , NO 2 , SH, S—C 1-6 alkyl, S-benzyl, O—C 1-6 -alkyl, OH, O—C 1-6 -alkyl-OH, ═O, O-benzyl, C(═O)C 1-6 -alkyl, CO 2 H, CO 2 —C 1-6 -alkyl, phenyl and benzyl; and if an aryl group or a heteroaryl group is mono- or poly-substituted, the substituents are independently selected from the group consisting of F, Cl, Br, I, CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , NO 2 , SH, S—C 1-6 -alkyl, OH, O—C 1-6 -alkyl, O—C 1-6 alkyl-OH, C(═O)C 1-6 -alkyl, C(═O)NHC 1-6 -alkyl; C(═O)-aryl; C(═O)—N-morpholine; C(═O)-piperidine; (C═O)-pyrrolidine; (C═O)-piperazine; NHSO 2 C 1-6 -alkyl, NHCOC 1-6 -alkyl, CO 2 H, CH 2 SO 2 -phenyl, CO 2 —C 1-6 -alkyl, OCF 3 , SCF 3 , CF 3 , C 1-6 -alkyl pyrrolidinyl, piperidinyl, morpholinyl, benzyloxy, phenoxy, phenyl, pyridyl, alkylaryl, thienyl and furyl; wherein said substituents optionally may be substituted with substituents selected from the foregoing group other than an aryl or heteroaryl ring; in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio; or a physiologically acceptable salt thereof.