Patent ID: 6620839
Filing Date: 2003-09-16
Classification: A61P,C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof, whereinZ is selected from the group consisting of a covalent bond and CH2; R1 is NR3R4; R3 and R4 are independently selected from the group consisting of hydrogen, alkenyl, alkenylcarbonyl, alkenyloxycarbonyl, alkenylsulfonyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, alkynylcarbonyl, alkynyloxycarbonyl, alkynylsulfonyl, aminocarbonyl, and aminosulfonyl; R7 is selected from the group consisting of hydrogen and alkyl; R8 is selected from the group consisting of 4-cyanophenyl, alkylcarbonyl, cycloalkylcarbonyl, and aryl; R9 is selected from the group consisting of hydrogen and lower alkyl; RA, RB, RC and RD are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfonyl, alkylthio, alkynyl, amino, aminoalkyl, aminocarbonyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, halogen, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, mercapto and nitro; wherein at each occurrence of said aryl, the aryl portion can be optionally substituted with 1, 2, or 3 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfonyl, alkylthio, alkynyl, amino, aminoalkyl, aminocarbonyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, halogen, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, mercapto, and nitro.