Patent ID: 7244349
Filing Date: 2007-07-17
Classification: B01L,G01N

Abstract:
1. A method for analyzing a plurality of membranous samples, such as cells, vesicles, and cellular organdies, comprising: selecting a measuring arrangement, comprising (i) a holder, and (ii) a plurality of measurement sites disposed in the holder, each measurement site having a carrier that separates from one another two fluid compartments, the carrier containing an aperture that connects the two compartments, wherein each carrier includes a binding surface adjacent the aperture that is adapted to seal a sample across the aperture, wherein each compartment is in electrical contact with at least one electrode, and wherein the diameter of each aperture immediately adjacent the binding surface is between about 0.3 μm and about 7 μm; providing a suspension of membranous samples to one of the fluid compartments of at least two measurement sites; sealing a first sample from the suspension across a first aperture in the measuring arrangement; measuring, using at least two of the electrodes, at least one of an electrical potential and a current across at least a portion of the first sample, after the first sample is sealed across the first aperture; sealing a second sample from the suspension across a second aperture in the measuring arrangement; and measuring, using at least two of the electrodes, at least one of an electrical potential and a current across at least a portion of the second sample, after the second sample is sealed across the second aperture.