Patent ID: 7105652
Filing Date: 2006-09-12
Classification: A01K,C07K

Abstract:
1. An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of: (i) the nucleotide sequence set forth in SEQ ID NO: 3; (ii) the nucleotide sequence set forth in SEQ ID NO: 5; (iii) a nucleotide sequence that encodes the amino acid sequence set forth in SEQ ID NO: 4; (iv) a nucleotide sequence that encodes the amino acid sequence set forth in SEQ ID NO: 4 wherein cysteine is substituted for alanine at position 2768; and (v) a nucleotide sequence of human origin that encodes a polypeptide having a molecular weight of about 300 kDa as determined by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 4 over its entire length wherein each difference between said amino acid sequence and SEQ ID NO: 4 does not reduce the ability of said polypeptide to bind ubiquitin or does not reduce the ability of said polypeptide to react with an antibody that binds to SEQ ID NO: 4.