Patent ID: 6676976
Filing Date: 2004-01-13
Classification: C07D

Abstract:
A process for the production of vasicine of formula (1) from the Adhatoda vasica, wherein no chromatographic separation is used, said process comprising the steps of: a. extracting the dried and pulverized leaves with an alcoholic extract at an ambient temperature, b. concentrating the alcoholic extract of step (a) to obtain a concentrated extract, c. treating and stirring extract of step (b) with an aqueous organic acid for 2-24 hours, d. extracting the acid solution of steps (c) with an organic solvent, e. separating the organic layer and aqueous acidic layer of step (d), f. basifying the aqueous acidic solution of step (e) with a base, g. extracting the basified solution of step (f) with an organic solvent, h. separating the organic layer of step (g) drying and filtering, i. evaporating the organic layer of step (h) to obtain an amorphous residue, and j. treating the amorphous residue of step (i) with a mixture of petroleum ether-acetone in the ratio of 1:1 to 2:1 to obtain vasicine that has a minimum purity of 80%.