Patent ID: 9220776
Filing Date: 2015-12-29
Classification: A61K,A61P,C07K

Abstract:
1. A stable lyophilized pharmaceutical formulation of an anti-human PD-1 antibody, wherein the formulation made by lyophilizing an aqueous solution comprising: a) 25-100 mg/mL of the anti-human PD-1 antibody; b) about 70 mg/mL sucrose; c) about 0.2 mg/mL polysorbate 80; and d) about 10 mM Histidine buffer at about pH 5.0-pH 6.0, and wherein the antibody, comprises: i) a light chain comprising amino acid residues 20 to 237 of SEQ ID NO: 36; and ii) a heavy chain comprising amino acid residues 20 to 466 of SEQ ID NO: 31.