Patent ID: 6139746
Filing Date: 2000-10-31
Classification: B01D,C07K,C12M

Abstract:
A process for purifying one or more target substances from a source liquid, said process comprising:contacting the source liquid with a chromatography resin;incubating the source liquid with the chromatography resin for a sufficient contact time to allow the resin to bind a desired fraction of one or more target substances,recirculating the chromatography resin in a cross-flow filter wherein the following steps are performed:concentrating the chromatography resin and separating contaminants from the chromatography-resin-bound target substance by concentration and/or diafiltration;eluting the target substance from the chromatography resin; andseparating the target substance from the chromatography resin by diafiltration;recovering the target; andoptionally concentrating the target substance.