Patent ID: 6495155
Filing Date: 2002-12-17
Classification: A61K,A61P,Y10S

Abstract:
A microparticle composition comprising:a buprenorphine free base in an amount in the range of 10 to 70 weight %, poly(D,L-lactide) as an excipient and a residual amount of ethyl acetate present in from about 0.1 to 3 weight %, wherein said composition provides a physiologically effective plasma level over a period of about 28 days of said buprenorphine free base to reduce the consumption of at least one of heroin and alcohol when administered intramuscularly in a mammal, and wherein at least 90 weight % of said microparticle composition comprises microparticles having a diameter in the range of 20 to 125 &mgr;m.