Patent ID: 6028169
Filing Date: 2000-02-22
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
An isolated polypeptide selected from the group consisting of:(a) a polypeptide comprising the amino acid sequence of residue 4 to residue m in SEQ ID NO:2, wherein m is any one of residues 48-93 of SEQ ID NO:2, and wherein said polypeptide inhibits the Chemokine Receptor-3 (CCR3) signaling pathway;(b) a polypeptide comprising the amino acid sequence of (a) except for one or more conservative amino acid substitutions, wherein said polypeptide inhibits the Chemokine Receptor-3 (CCR3) signaling pathway; and(c) a polypeptide comprising a sequence at least 80% identical to the amino acid sequence of (a), wherein % identity is determined using the Bestfit program with parameters that calculate % identity over the fall length of sequence (a) and that allow gaps in homology of up to 20% of the total number of residues in sequence (a), and wherein said polypeptide inhibits the Chemokine Receptor-3 (CCR3) signaling pathway.