Patent ID: 9101654
Filing Date: 2015-08-11
Classification: A61K,A61L,C08L

Abstract:
1. A bioresorbable composite composition comprising: a biodegradable hydrogel polymer crosslinked to ceramic particles, the biodegradable hydrogel polymer comprising a poly(lactide-co-glycolide) block, a poly(ethylene oxide) block, and a fumarate group, the fumarate group comprising reactive groups for crosslinking the biodegradable hydrogel polymer, the biodegradable hydrogel polymer being formed by reaction of a poly(lactide-co-glycolide) polymer having a number average molecular weight of greater than 500 Daltons and less than 8,000 Daltons with a poly(ethylene oxide) compound having a number average molecular weight of from 500 Daltons to 5,000 Daltons and with a fumaryl compound, the biodegradable hydrogel polymer having a number average molecular weight of less than 15,000 Daltons and having a polydispersity index of less than 3.5, wherein the molar ratio of the polylactide-co-glycolide) polymer to the fumaryl compound is from 1:0.8 to 1:0.99, the biodegradable hydrogen polymer being crosslinked to the ceramic particles by a crosslinking agent that comprises a peptide crosslinking agent or that comprises methylene bis acrylamide.