Patent ID: 8664202
Filing Date: 2014-03-04
Classification: A61F,A61K,A61L,A61P,B29C,B29L,Y10T

Abstract:
1. A method for promoting tissue regeneration in mammals comprising the steps of: identifying a specific site in need of tissue regeneration; and administering a therapeutically effective amount of a cross-linked bioactive hydrogel matrix to the identified site; wherein the bioactive hydrogel matrix comprises a polyglycan covalently cross-linked to a polypeptide and further comprising at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof; wherein the polyglycan is a polysaccharide or a sulfated polysaccharide selected from the group consisting of glycosaminoglycans, glucosaminoglycans, dextran, heparan, heparin, hyaluronic acid, alginate, agarose, carageenan, amylopectin, amylose, glycogen, starch, cellulose, chitin, heparan sulfate, chondroitin sulfate, dextran sulfate, dermatan sulfate, and keratan sulfate; wherein the polypeptide is a tissue-derived polypeptide selected from the group consisting of collagens, gelatins, keratin, decorin, aggrecan, glycoproteins, laminin, nidogen, fibulin, and fibrillin; and wherein the covalently cross-linked hydrogel matrix is a solid or semi-solid material at physiological temperature and physiological pH.