Patent ID: 7304186
Filing Date: 2007-12-04
Classification: A61P,C07C

Abstract:
1. A method for preparing a compound of the formula (I) wherein R 0 is hydrogen or any other substituent; R 3 , R 4 and R 5 are each, independently, hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl or aralkyl group, optionally including at least one heteroatom in its carbon skeleton, or R 3 and R 4 together form part of a single or fused ring structure, optionally including at least one heteroatom in its carbon skeleton; which comprises reacting a compound of the formula (II) wherein R 6 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl or aralkyl group, optionally including at least one heteroatom in its carbon skeleton, each R 6 group being the same or different, with an organometallic compound of the formula (III) wherein M is a metal ion of an organometallic complex, and reacting the conjugate addition product so obtained in situ with a compound of the formula (IV) to form a compound of the formula (I).