Patent ID: 6455572
Filing Date: 2002-09-24
Classification: A61P,C07B,C07C,C07D

Abstract:
A metabolite of (âˆ’)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol corresponding to formula I: wherein R1 is selected from orNH(CH2)3COR6; R5 is selected from H or CH3; R2, R3, R4 and R7 are the same or different and are selected from H and OR5; and R6 is selected from â€”OH, or â€”NHCH2COOH, provided that: (a) if R1 is â€ƒor â€”NH(CH2)3COOH and (b) R2 is OH or OCH3 and R3 and R7 are H, or if R1 is as defined in (a) above and (c) R2 and R7 are H and R3 is OH or OCH3, then R4is not H; and further provided that when R2, R3, R4 and R7 are H, then R1 is not or an optical, stereo, regio or configurational isomer or geometric isomer thereof or a tautomer, pharmaceutically acceptable salt, N-oxide, ester, quaternary ammonium salt, or prodrug thereof.