Patent ID: 7763631
Filing Date: 2010-07-27
Classification: A61P,C07D

Abstract:
1. A compound of formula a N-oxide form, a pharmaceutically acceptable addition salt, and a stereochemically isomeric form thereof, wherein R (A a N-oxide, a pharmaceutically acceptable addition salt, and a stereochemically isomeric form thereof, wherein -a n is 0, 1, 2, 3 or 5; each R L is C L is —X Q represents hydrogen, C R R R R R R R R R R Y represents hydrogen, hydroxy, halo, C p is 1 or 2; aryl aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C Het Het is a saturated, partially saturated or unsaturated (aromatic) heterocyclic radical; said saturated heterocyclic radical is selected from pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl and tetrahydrothienyl wherein each of said saturated heterocyclic radicals may optionally be substituted with an oxo group; said partially saturated heterocyclic radical is selected from imidazolinyl, pyrazolinyl, pyrrolinyl, 4,5-dihydro-oxazolyl, 4,5-dihydro-thiazolyl, dihydrofuranyl, dihydrothienyl; and said aromatic heterocyclic radical is selected from pyrrolyl, furanyl, thienyl, pyridyl, pyrimidinyl, pyrazinyl and pyridazinyl wherein each of said aromatic heterocyclic radicals may optionally be substituted with hydroxyl.