Patent ID: 6815448
Filing Date: 2004-11-09
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinR1 is hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; R2 is hydrogen, halo, trifluoromethyl, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkoxy of one to six carbon atoms or alkyl of one to six carbon atoms; Z is pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, R3 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms or alkynyl or 3 to 6 carbon atoms; Ar is phenyl, pyridinyl, pyrimidinyl, pyrazinyl, furyl, or thienyl; R4 is hydroxy, cyano or carboxamido and R5 is Ar; or R4 is hydrogen and R5 is benzoyl, 1-benzimidazol-2-onyl, benzoisothiazolyl, benzisoxazolyl, or â€”(CH2)mQ; m is 0 to 4; and Q is Ar, or a pharmaceutically acceptable salt thereof, wherein said phenyl, naphthyl, pyrimidinyl, pyrazinyl, furyl, thienyl, 1-benzimidazol-2-onyl, benzoisothiazolyl, or benzisoxazolyl groups are optionally substituted with substituents selected from hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alky of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms.