Patent ID: 6693199
Filing Date: 2004-02-17
Classification: A61P,C07C,C07D,C07F

Abstract:
A method of making a compound of formula (1): wherein:Q1 and Q2 are independently selected from hydrogen and substituted and unsubstituted alkyl and aryl, and Q1 and Q2 may form a ring with G; Q3 is selected from mercapto and substituted and unsubstituted alkoxyl, aryloxyl, thioether, amino, alkyl, cycloalkyl, saturated and partially saturated heterocycle, and aryl; Q4-Q8 are independently selected from hydrogen, hydroxyl, mercapto, nitro, halogen, â€”Oâ€”J, wherein J is a substituted or unsubstituted hydrolyzalble group, and substituted and unsubstituted alkoxyl, aryloxyl, thioether, acyl, sulfinyl, sulfonyl, amino, alkyl, cycloalkyl, saturated and partially saturated heterocycle and aryl, and further wherein any one of Q4-Q8 may be a member of a spiro ring and any two of Q4-Q8 may together be members of a ring; Y and G are independently selected from oxygen, â€”NH, â€”Nâ€”alkyl, sulfur, selenium, and two hydrogen atoms; D is carbon or nitrogen; E is carbon or nitrogen; Q9 is selected from hyrogen, halogen, hydroxyl, mercapto, and substituted and unsubstituted alkoxyl, aryloxyl, thioether, amino, alkyl, and aryl, wherein Q9 may form part of a ring; A is a carbocycle or heterocycle, which is optionally further substituted; and B is a carbocycle or heterocycle, which is optionally further substituted, said method comprising reacting a compound of formula (IA): with a compound of formula (IB): to obtain the compound of formula (1).