Patent ID: 7964567
Filing Date: 2011-06-21
Classification: A61K,A61P,C07K,Y02A,Y10T

Abstract:
1. A method for treating cancer comprising administering to a patient in need thereof an effective amount of an antibody-drug conjugate compound having the formula IIa: or a pharmaceutically acceptable salt thereof, wherein: Ab is an antibody that specifically binds to an antigen expressed by the cancer, R r is an integer rangin from 1 to 10; p ranges from 1 to about 20, and D is a drug moiety of Formula D the wavy line of D wherein, independently at each location: R R R R or R R R each R R R Z is O, S, NH, or NR R m is an integer ranging from 1-1000; R R each occurrence of R each occurrence of R n is an integer ranging from 0 to 6.