Patent ID: 6436932
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof whereinAr is phenyl, 1- or 2-naphthyl, 2-, 3-, or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, optionally mono-, di-, or tri-substituted with halogen, trifluoromethyl, hydroxy, amino, lower alkylamino, lower dialkylamino, carboxamido, lower alkylcarboxamido, N,N-lower dialkylcarboxamido, lower alkyl, lower alkoxy, with the proviso that at least one of the positions ortho or para to the point of attachment of Ar to the bicyclic ring system is substituted; R1 is hydrogen, halogen, trifluoromethyl, lower alkyl, or (C1-C6 alkyl)-G1â€”R2 where G1 is oxygen or sulfur and R2 is hydrogen or C1-C6 alkyl; Q1 is hydrogen, lower alkyl, halogen, lower alkoxy, amino, methylamino, dimethylamino, hydroxymethyl, or SOn(C1-C4 alkyl) where n is 0, 1 or 2, cyano, hydroxy, â€”C(O) (C1-C4 alkyl), â€”CHO, â€”CO2(C1-C4 alkyl), â€”CO2(C1-C4 alkenyl), or â€”CO2 (C1-C4 alkynyl); Q2 is hydrogen, lower alkyl, halogen, hydroxymethyl, methoxymethyl, or lower alkoxy; and X is a group of the formula â€ƒwherein V1 is CH2 or CH(lower alkyl); Y1 represents a bond or lower alkylene; A1 is NR4R5 wherein R4 and R5 are independently lower alkyl; or A1 is NR4R5 wherein R4 and R5 are taken together to form a morpholinyl, piperazinyl, piperidinyl, or pyrrolidinyl group.