Patent ID: 6080745
Filing Date: 2000-06-27
Classification: A61P,C07D

Abstract:
A compound of formula I, or a salt thereof or a prodrug thereof: ##STR13## wherein the broken line represents a double bond whereby the ring containing Q is heteroaromatic;W is selected from the group consisting of phenyl or 2,3-thienyl, which ring can be substituted by one or more substituents selected from the group consisting of: halogen, trifluoromethyl, cyano, nitro, amino, C.sub.1-6 alkylamino, di(C.sub.1-6)alkylamino, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, aryl(C.sub.1-6)alkoxy and C.sub.2-6 alkylcarbonyl;Q is selected from .dbd.N--NR.sup.5 --, --NR.sup.5 --N.dbd., .dbd.N--O--, --O--N.dbd. and .dbd.N--CR.sup.6 .dbd.N--;Z represents a chemical bond, or a methylene or ethylene group;R.sup.1, R.sup.2 and R.sup.5 independently represent hydrogen or C.sub.1-6 alkyl;one of R.sup.3 and R.sup.4 represents hydrocarbon, selected from the group consisting of: C.sub.2-6 alkenyl, C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, aryl(C.sub.1-6)alkyl and heteroaryl(C.sub.1-6)alkyl, wherein heteroaryl is selected from the group consisting of: pyridyl, quinolyl, isoquinolyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrazinyl, furyl, benzofuryl, dibenzofuryl, thienyl, benzthienyl, indolyl, aza-indolyl, imidazolyl, oxadiazolyl and thiadiazolyl; or a heterocyclic group selected from the group consisting of: azetidinyl, pyrrolidyl, piperidyl, piperazinyl and morpholinyl; in which each R.sup.3 and R.sup.4 substitutent can be substituted by C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy or nitro,and the other of R.sup.3 and R.sup.4 represents hydrogen, hydrocarbon or a heterocyclic group, as defined above; andR.sup.6 represents C.sub.1-6 alkyl or --NR.sup.a R.sup.b, in which R.sup.a and R.sup.b independently represent hydrogen or C.sub.1-6 alkyl.