Patent ID: 7129209
Filing Date: 2006-10-31
Classification: A61F,A61L,Y10S

Abstract:
1. A method for preparing a crosslinkable composition that crosslinks in situ following administration to a patient to form a heterogeneous, crosslinked biomaterial composition, comprising: an aqueous suspension of a biomaterial comprised of a biocompatible polymer containing nucleophilic groups; and a dry mixture of a hydrophilic crosslinking agent and a hydrophobic crosslinking agent containing up to about 14 carbon atoms and comprising a polyacid esterified with reactive moieties selected from succinimidyl groups and sulfosuccinimidyl groups, wherein the hydrophilic crosslinking agent and the hydrophobic crosslinking agent are each capable of covalently crosslinking the biomaterial but are not reactive with respect to each other.