Patent ID: 7838220
Filing Date: 2010-11-23
Classification: C07K,C12Q

Abstract:
1. A method of screening for a human individual's predisposition to atopy, the method comprising: analyzing said individual for the presence of an INS157 polymorphism in TIM-1 by contacting a biological sample comprising DNA or mRNA from such individual with a probe that specifically binds to the nucleic acid sequence ATGACAACGACTGTTCCA, SEQ ID NO:22, bases 472-489, encoding the amino acid sequence MTTTVP, SEQ ID NO:25, residues 158-163; detecting the presence of a complex formed between said probe and said genomic DNA, mRNA or a transcript thereof; and analyzing said individual for the presence of hepatitis A virus (HAV) seropositivity wherein said seropositivity in an individual comprising an allele of TIM-1 comprising the amino acid sequence MTTTVP, SEQ ID NO:25, residues 158-163 is indicative of a reduced risk of developing atopy.