Patent ID: 6110470
Filing Date: 2000-08-29
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
An isolated and purified DNA molecule selected from the group consisting of:a) a DNA molecule that encodes a polypeptide derivative comprising the amino acid sequence of SEQ ID NO:1, lacking amino acids 1043-1130;b) a DNA molecule that encodes a polypeptide derivative comprising the amino acid sequence of SEQ ID NO:1, lacking amino acids 1130-1285; andc) a DNA molecule encoding a detoxified polypeptide derivative of Pasteurella multocida toxin, wherein the derivative is a truncated form of the toxin and comprises an amino acid sequence that is identical to but shorter than the amino acid sequence of the Pasteurella multocida toxin of SEQ ID NO:1, and wherein the toxin derivative specifically binds an antibody that specifically binds Pasteurella multocida toxin (PMT).