Patent ID: 7109181
Filing Date: 2006-09-19
Classification: A61K,A61P,C07H

Abstract:
1. A method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment comprising: administering to a subject a pharmaceutical composition comprising a P2Y purinergic receptor agonist in an amount therapeutically effective to alter the amount or composition of synovial fluids, wherein said P2Y purinergic receptor agonist is administered to achieve a joint fluid concentration range of about 10 wherein: X T, T′, W, and V are independently or together oxygen or sulfur; m=0, 1 or 2; n=0 or 1; p=0, 1, or 2; where the sum of m+n+p is from 1 to 5; each M is independently hydrogen or a pharmaceutically-acceptable inorganic or organic counterion; A=M, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl, aralkynyl, aryl, or acylthioalkyl, with or without substituents or heteroatoms; or A is a nucleoside residue defined as: wherein: D Z and Z′ are independently H, OR Y and Y′ are independently H, F, OR independently R wherein: Q is a carbon atom; R R provided that R provided that R provided that R B and B′ are independently a purine or a pyrimidine residue according to Formulae III or IV which is linked to the 1′-position of the furanose or carbocycle via the 9-position of the purine or the 1-position of the pyrimidine; wherein: R R or when R R R R R R R R R R R R R W