Patent ID: 7521415
Filing Date: 2009-04-21
Classification: A61K,C07K,C12N

Abstract:
1. A method of transporting a peptide into an isolated mammalian cell comprising: pretreating the isolated mammalian cell with a composition comprising at least one compound comprising a recurring unit represented by a formula selected from the group consisting of formula (I) and (II); administering the peptide to the pretreated cell, and transporting the peptide into the pretreated mammalian cell, wherein the peptide has 2 to 50 amino acids and wherein formula (I) and (II) are represented by: wherein A comprises at least one acetal group; wherein B is selected from the group consisting of —CH—, —CH(CH wherein Z is selected from the group consisting of C(O)OR wherein V is a linker group; wherein U is selected from the group consisting of poly(ethyleneimine) (PU), poly(propyleneimine) (PPI), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; wherein R wherein D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and wherein G is selected from the group consisting of C