Patent ID: 7335770
Filing Date: 2008-02-26
Classification: A61P,C07D

Abstract:
1. A compound selected from: N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-[2-(2-fluoro-phenoxy)-ethoxy]-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(1-methyl-pyrrolidin-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(1-methyl-piperidin-4-yloxy)-[1,3,5]triazine-2,4-diamine; 3-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-2-ethyl-pyran-4-one; 1-{3-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-piperidin-1-yl}-ethanone; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-isopropoxy-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2-fluoro-phenoxy)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(6-methyl-pyridin-2-yloxy)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(4-iodo-phenoxy)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2-iodo-phenoxy)-[1,3,5]triazine-2,4-diamine; 4-{4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-phenyl}-2-methyl-but-3-yn-2-ol; 4-{2-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-phenyl}-2-methyl-but-3-yn-2-ol; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(pyridin-3-yloxy)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(1-ethyl-piperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine; 4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-benzaldehyde; 3-{4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-phenyl}-acrylic acid ethyl ester; 1-{4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-phenyl}-ethanone; 4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-benzaldehyde oxime; 1-{3-Chloro-4-[4-(3-chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yloxy]-phenyl}-ethanone; 4-{4-[4-(3-Chloro-4-methoxy-phenylamino)-6-isopropylamino-[1,3,5]triazin-2-yloxy]-phenyl}-2-methyl-but-3-yn-2-ol; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-phenylsulfanyl-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2-methoxy-phenylsulfanyl)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(4-fluoro-phenylsulfanyl)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2,6-dichloro-phenylsulfanyl)-[1,3,5]triazine-2,4-diamine; 6-(2-tert-Butyl-phenylsulfanyl)-N-(3-chloro-4-methoxy-phenyl)-N′-cycloheptyl-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2,4-dimethoxy-phenyl)-[1,3,5]triazine-2,4-diamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2,4,6-trimethoxy-phenyl)-[1,3,5]triazine-2,4-diamine; 4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yl]-benzene-1,3-diol; 1-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yl]-naphthalen-2-ol; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(tetrahydro-furan-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine; 4-{4-Cycloheptylamino-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-cyclohexanol; N-Cycloheptyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine; N-Cycloheptyl-N′-(3-fluoro-4-methyl-phenyl)-N″-methyl-N″-(1-methyl-piperidin-4-yl)-[1,3,5]triazine-2,4,6-triamine; N-Cycloheptyl-N′-methyl-N′-(1-methyl-piperidin-4-yl)-N″-(3-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine; N-Cycloheptyl-N′-(3-fluoro-phenyl)-N″-methyl-N″-(1-methyl-piperidin-4-yl)-[1,3,5]triazine-2,4,6-triamine; N-(4-Benzyloxy-3-chloro-phenyl)-N′-cycloheptyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine; N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine; 2,4,6-Tris-(3-fluoro-4-methoxy-phenoxy)-[1,3,5]triazine; {2-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-ylamino]-ethyl}-carbamic acid tert-butyl ester; N-Cycloheptyl-6-ethoxy-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine; N-(2-Amino-ethyl)-N′-(3-chloro-4-methoxy-phenyl)-N″-cycloheptyl-[1,3,5]triazine-2,4,6-triamine; 4-(5-{4-[4-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-ylamino]-piperidin-1-yl}-5-oxo-pentyl)-tetrahydro-thieno[3,4-d]imidazol-2-one; 5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoic acid {5-[4-(3-chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-ylamino]-pentyl}-amide; 5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoic acid N′-[4-(3-chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-yl]-hydrazide; 5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoic acid {2,-[4-(3-chloro-4-methoxy-phenylamino)-6-cycloheptylamino-[1,3,5]triazin-2-ylamino]-ethyl}-amide; 2-{4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-piperazin-1-yl}-1-pyrrolidin-1-yl-ethanone; or 2-{4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5triazin-2-yl]-piperazin-1-yl}-1-pyrrolidin-1-yl-ethanone dihydrogen chloride salt.