Patent ID: 6255349
Filing Date: 2001-07-03
Classification: C07C,C07D

Abstract:
A compound having the formula: ##STR9##whereinR.sub.1 -R.sub.5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, --CN, --NO.sub.2, --CO.sub.2 R.sub.6, --COR.sub.6, --OR.sub.6, --SR.sub.6, --SOR.sub.6, --SO.sub.2 R.sub.6, --CONR.sub.7 R.sub.8, --NR.sub.6 N(R.sub.7 R.sub.8), --N(R.sub.7 R.sub.8) or W--Y--(CH.sub.2).sub.n --Z provided that at least one of R.sub.1 -R.sub.5 is not hydrogen; or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl;R.sub.6 and R.sub.7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;R.sub.8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, orR.sub.7 and R.sub.8, taken together may form a 3 to 7 membered heterocycloalkyl;W is O, NR.sub.6, or is absent;Y is --(CO)-- or --(CO.sub.2)--, or is absent;Z is alkyl of 1 to 4 carbon atoms, --CN, --CO.sub.2 R.sub.6, COR.sub.6, --CONR.sub.7 R.sub.7, --OCOR.sub.6, --NR.sub.6 COR, --OCONR.sub.6, --OR.sub.6, --SR.sub.6, --SOR.sub.6, --SO.sub.2 R.sub.6, SR6N(R7R8), --N(R.sub.7 R.sub.8) or phenyl;G is aryl;X is a bond, --NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J;J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; andn is an integer from 1 to 6; or a pharmaceutically acceptable salt thereof.