Patent ID: 8227497
Filing Date: 2012-07-24
Classification: A61P,C07D

Abstract:
1. A method for treating hypertension or heart failure, comprising administering to a patient a therapeutically effective amount of the compound of formula Ia: where: Y is: Q is —C(R 3 )—, Z is a bond, and W is —N—; or Y is: Q is —C(R 3 )—, Z is —C(O)—, and W is —N—; R R R Ar—X—CR X is selected from —SO R R 5ea is —O—C 1-6 alkyl, —O—C 3-7 cycloalkyl, —NR 5eb R 5ec , or —CH(NH 2 )CH 2 COOCH 3 ; R 5eb and R 5ec are independently H, —C 1-4 -alkyl, or —C 1-3 alkylenearyl, or are taken together as —(CH 2 ) 3-6 —; R 5f is H, —C 1-4 alkyl, —C 0-3 alkylenearyl, —C 1-3 alkylene-NR 5fa R 5fb , or —C 1-3 alkylene(aryl)-C 0-3 alkylene-NR 5fa R 5fb ; R 5fa and R 5fb are independently H or —C 1-4 alkyl; R 5g is H, —C 1-6 alkyl, —C 1-3 alkylenearyl, or —CH 2 —O—(CH 2 ) 2 —OCH 3 ; R 5h is H or —C 1-4 alkyl; R 5i is H, —C 1-4 -alkyl, or —C 0-3 alkylenearyl; and R 5j is —C 1-6 alkyl, aryl, or —CH 2 CH(NH 2 )COOH; R R one —CH each alkyl and each aryl in R each ring in Ar—X—CR or a pharmaceutically acceptable salt thereof.