Patent ID: 8288559
Filing Date: 2012-10-16
Classification: C07D,C12Q,G01N

Abstract:
1. A compound of formula (I): wherein Y is N,N-oxide, N—(C X is S, O, CH═CH, N═CH, or CH═N; each X* is independently O or S; R′ and R″ are independently (C Z is H, OH, OR, NH W a W each W each of K the dotted line in ring B is an optional bond; each R is independently H, (C or when Z is NRR, RR together with the N to which they are attached optionally form a heteroaryl or heterocycle group; wherein any alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, amino, aryl, heteroaryl, or heterocycle group is optionally substituted with 1, 2, 3, 4, or 5 substituents selected from (C or a salt thereof; when Z comprises a nitrogen moiety, one or both of the hydrogens of the Z nitrogen moiety may be replaced by (C when Z is a hydroxyl group or a nitrogen moiety, H of the hydroxyl or nitrogen moiety may be replaced by (HO) when Z is a hydroxyl group or a nitrogen moiety, one H of the hydroxyl or nitrogen moiety may be replaced by the group L′-linker, wherein L′ is a group removable by an enzyme to free the linker, and linker is a carbon chain that can self-cleave, optionally interrupted by one or more nitrogen atoms, oxygen atoms, carbonyl groups, optionally substituted aromatic rings, or peptide bonds; linker is attached to L′ via an oxygen atom or an NH group at one terminus of the linker and the other terminus of the linker forms an ether, ester, or amide linkage with a group Z; and when Z is OR, formula I is optionally a dimer connected at the two A rings via a linker comprising a (C