Patent ID: 6525154
Filing Date: 2003-02-25
Classification: B01J,C08F,G01N

Abstract:
A method for preparing a molecularly imprinted polymer wherein the template comprises a peptide or amino acid sequence having an N-terminal histidine residue or histamine, said method comprising the steps of:(A) providing a template complex that has the general formula wherein M is nickel, cobalt, copper, zinc, lead or manganese, P is a template peptide or amino acid sequence having at least one N-terminal histidine or a histamine molecule, n=0 through 10, X is NH, O, S or is absent and A is H or alkyl; (B) polymerizing the template complex provided in Step A with at least a first monomer and optionally said first monomer and a second monomer, to form a polymer network containing the template complex; the first monomer having the general formula wherein Y is NH, O or S or is absent, n1=0 through 10, n2=0 through 2, n3=0 through 10 and B is H or alkyl and the second monomer, if used, having the general formula wherein Z=NH2, OH, Oâ€”(CH2)n wherein n=2 through 4, NH(alkyl) or N(alkyl)2 and Q is H or alkyl.