Patent ID: 9127302
Filing Date: 2015-09-08
Classification: C12Q

Abstract:
1. A system for the detection and enumeration of suspect target cells in a mixed cell population, comprising: a. means for obtaining a biological specimen from a test subject, said specimen comprising a mixed cell population suspected of containing target cells; b. means for isolating a subpopulation of suspect said target cells by immunomagnetic enrichment using colloidal magnetic particles; c. means for identifying suspect target cells by a phenotypic profile analysis means wherein a magnetic holding force holds said target cells for imaging; d. means for preparing suspect target cells identified by the means of step c for a genotypic profile analysis means wherein shear forces to replace preparatory buffers on the target cells are less than the magnetic holding forces required to maintain the target cells for imaging; and e. means for confirming suspect target cells by said genotypic profile wherein said individual suspect target cell contains both phenotypic and genotypic characteristics.