Patent ID: 9029323
Filing Date: 2015-05-12
Classification: A61K,A61P,C07K

Abstract:
1. A neurturin conjugate comprising a polyol moiety covalently bound to a human neurturin protein product, wherein said neurturin protein product is capable of dimerizing with a neurturin protein having the amino acid sequence of SEQ ID NO: 5, wherein said neurturin protein product comprises the amino acid sequence of SEQ ID NO: 5 or a biologically active fragment thereof, but with 1, 2, 3, or 4 amino acid alterations, wherein the amino acid alterations are: a) the substitution of 1, 2, 3 or 4 arginine residues at amino acid positions 51, 52, 54, 56, 57, 58, 60, 61, 63 or 65 of SEQ ID NO: 5 with a lysine, and/or b) the substitution of 1, 2, 3 or 4 arginine residues at amino acid positions 51, 52, 54, 56, 57, 58, 60, 61 or 65 of SEQ ID NO: 5 with a glutamic acid.