Patent ID: 7598027
Filing Date: 2009-10-06
Classification: A61P,G01N

Abstract:
1. A method of detecting Botulinum toxin serotype A (BoNT/A) activity in a sample, the method comprising the steps of: a) contacting a sample to a cell that contains an exogenous Fibroblast Growth Factor Receptor 3 (FGFR3) and an endogenous synaptosome-associated protein of 25000 Daltons (SNAP-25), wherein said cell is genetically engineered to express a nucleic acid molecule encoding said FGFR3; and wherein said cell is capable of BoNT/A intoxication; and b) detecting the presence of BoNT/A activity of said cell relative to a control cell by detecting the presence of endogenous SNAP-25 cleavage product from said cell.