Patent ID: 6610835
Filing Date: 2003-08-26
Classification: C07F,C07H

Abstract:
A sphingolipid derivative of the formula: whereinA is a spacer group which is (CH2)m where m=0-14, where any of the hydrogens may be independently replaced by R1 or X and where any two adjacent carbons may be independently replaced by a C3-C8 cycloalkyl group, a 1,2-, 1,3-, or 1,4-disubstituted benzene group, or a 2,3- 2,4-, or 2,5-disubstituted thiophene, furan or pyrrole group; Y, V and Q are independently hydrogen, OR1, NR2, CN, alkyl, acyl or carboxylate, and wherein alternatively, V and Y or Y and Q can together constitute a double or triple bond; X is hydrogen; W=no substituent, H, alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, C(O)(CH2l )nCO2H, C(O)(CH2)nCW'2CO2H or OR1; W' is selected independently from H, alkyl, aryl, (CH2)nCO2H; (CH2)nCH(CO2H)â€”CH2CO2H; and (CH2)nCH(CO2H)CH(CH2CO2H)CO2H; Z is H, O, NH, NR, NHC(O), CO2, C(O)NH or C(O)NR; R is selected independently from H, alkyl, acyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl or heteroaryl; R1 is R or R2; R2 is &bgr;-D-galatoside, N-acetyl-&bgr;-D-glucosamine, &agr;-D-mannoside, &bgr;-D-cellobioside, &bgr;-D-glucopyranoside, &bgr;-D-galatopyranoside, &bgr;-D-glucuronide, starch, lactose, raffinose, stachyose, fructo-oligo-saccharide, or amide or ester of &bgr;-cyclodextrin, or dextran linked via succinate or glutarate, or furanose or pyranose carbohydrate; wherein there is at least one R2 substituent in the sphingolipid derivative.