Patent ID: 7704704
Filing Date: 2010-04-27
Classification: A61P,C12Q,G01N

Abstract:
1. A system for measuring glucose, said system comprising: (a) an implantable glucose-sensing device comprising: a hydrogel having a matrix; a functionalized polymer or functionalized nano-particle ligand; a sugar-binding molecule comprising Concanavalin A, other sugar-binding lectins, glucose binding protein, glucose oxidase, or glucose apo-oxidase; and a first fluorophore comprising a fluorescein, a rhodamine, a cyanine, or a fluorescent dye linked to the ligand or the sugar-binding molecule; wherein the ligand and the sugar-binding molecule are present throughout the matrix of the hydrogel, wherein the first fluorophore is a quenchable fluorophore having a fluorescent emission spectrum operable to be quenched upon binding or release of glucose by the sugar-binding molecule; and (b) a light source configured and arranged to illuminate the implantable glucose sensing device with light of a wavelength sufficient to excite the quenchable fluorophore; (c) a detector (a) in optical communication with the implantable glucose sensing device and (b) configured and arranged to detect at least at least one wavelength of light from the implantable glucose sensing device and produce a detected light signal; (d) a processor in communication with the detector and configured and arranged to receive and process at least one detected light signal to produce a glucose metric; (e) a display operably linked to the processor and configured and arranged to receive and display the glucose measurement; and (f) a power source operably linked to at least the light source, the detector, the processor, and the display.