Patent ID: 7771952
Filing Date: 2010-08-10
Classification: A61K,C07K,G01N,Y10S

Abstract:
1. A method for identifying an agent which modulates the binding of a Repulsive Guidance Molecule (RGM) to a Neogenin, the method comprising the steps of: (a) forming a mixture comprising an isolated mammalian RGM and an isolated mammalian Neogenin, wherein the isolated mammalian Neogenin has the amino acid sequence of SEQ ID NO: 1; (b) incubating said mixture in the presence of an agent; and (c) detecting in the incubated mixture of step (b) the level of specific binding between said RGM and said Neogenin, wherein a difference in the detected level of specific binding of said RGM to said Neogenin in the presence of said agent relative to the level of specific binding in the absence of said agent indicates that said agent modulates the binding of said RGM to said Neogenin, wherein said RGM is RGM A or RGM B.