Patent ID: 6268341
Filing Date: 2001-07-31
Classification: A61K,A61P,C07K,C12N,C12Y,C40B

Abstract:
An unfucosylated huantagonist polypeptide, which polypeptide comprises at most the 48 amino-terminal amino acid residues of huPA (huPA.sub.1-48), wherein huPA.sub.1-48 has the polypeptide sequence Ser-Asn-Glu-Leu-His-Gln-Val-Pro-Ser-Asn-Cys-Asp-Cys-Leu-Asn-Gly-Gly-Thr-Cy s-Val-Ser-Asn-Lys-Ty-Phe-Ser-Asn-Be-His-Tm-Cys-Asn-Cys-Pro-Lys-Lys-Phe-Glv- Gly-Gln-His-Cys-Glu-Ile-Asp-Lys-Ser-Lys (SEQ ID NO:22), or comprises an active analog thereof, wherein an active analog refers to a polypeptide that differs from said huPA.sub.1-48 (SEQ ID NO:22) by at most one to seven amino acids, and having a binding affinity that is substantially the same or greater than that of huPA.sub.1-48 (SEQ ID NO:22) with huPAR.