Patent ID: 7504408
Filing Date: 2009-03-17
Classification: A61P,C07D

Abstract:
1. A quinazoline derivative of the Formula I wherein Z is an O, S, SO, SO 2 , N(R 2 ) or C(R 2 ) 2 group, wherein each R 2 group, which may be the same or different, is hydrogen or (1-6C)alkyl; m is 1 or 2; each R wherein X and wherein adjacent carbon atoms in any (2-6C)alkylene chain within a R and wherein any CH and wherein any heterocyclyl group within a substituent on R and wherein any heterocyclyl group within a substituent on R n is 0, 1 or 2; and R wherein X 6 is a direct bond or is selected from O and N(R 12 ), wherein R 12 is hydrogen or (1-6C)alkyl, and R 11 is halogeno-(1-6C)alkyl, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl or di-[(1-6C)alkyl]amino-(1-6C)alkyl; Z R wherein x is 0, 1, 2 or 3, R 3 is hydrogen or (1-6C)alkyl and R a and R b are each independently selected from hydrogen and (1-6C)alkyl or R a and R b together with the nitrogen to which they are attached form morpholino or from a group of the formula: wherein X 7 is a direct bond and Q 5 is aryl, heteroaryl, heterocyclyl, heterocyclyl-(1-6C)alkyl or heterocyclyloxy-(1-6C)alkyl, and wherein any CH, CH wherein X 8 is a direct bond or O and Q 6 is aryl, (3-7C)cycloalkyl, (3-7C)cycloalkyl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, and wherein any aryl, cycloalkyl or heterocyclyl group within a substituent on R and wherein any heterocyclyl group within a substituent on R or a pharmaceutically-acceptable salt thereof.