Patent ID: 8034395
Filing Date: 2011-10-11
Classification: A61B,A61F,A61L,B82Y,C04B,C23F,Y10T

Abstract:
1. A method which comprises precipitating mono or multiple layers of a mixture of at least two different acids selected from the group consisting of organophosphoric acids of the general formula I (A) or of organophosphonic acids of the general formula I (B) and the salts thereof, on a substrate surface of pure or mixed oxides, nitrides or carbides of metals or semiconductors, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinirnydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic recognition element is coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring on the substrate surface a resistance to protein adsorption and/or to cell adhesion and the B chain may optionally be comprised of one or more ethylene oxide groups, rather than one or more —CH2-groups, and wherein the organophosphoric acid or organophosphonic acid is precipitated from water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, of sensor platforms, implants and medical accessory devices, and wherein the biochemical, biological or synthetic recognition elements (coupled to B or Y) are selected from among the group of nucleic acids, such as DNA, RNA, oligonucleotides, nucleic acid analogs, such as PNA, monoclonal or polyclonal antibodies, peptides, enzymes, aptamers, synthetic peptide structures, soluble membrane-bound proteins and proteins isolated from a membrane, such as receptors, ligands thereof, antigens for antibodies, biotin, “histidine tag components” and complexing partners thereof.