Patent ID: 6315984
Filing Date: 2001-11-13
Classification: A61K

Abstract:
A pressurized container containing a stable solubilized mixture of propellant which is liquid under pressure and an intermediate aerosol formulation which comprises a pharmaceutical agent, water, first ingredient, second ingredient and at least one third ingredient, wherein the first ingredient is selected from the group consisting of glycerin and polyglycerin and mixtures thereof in an amount of from 1-50 wt./wt. % of the intermediate formulation, the second ingredient is selected from the group consisting of phenol, methyl phenol and mixture's thereof in an amount of from 1-20 wt./wt. % of the intermediate formulation, each third ingredient is selected from the group consisting of alkali metal C8 to C22 alkyl sulphate, polidocanol C6 to C40 alkyl ethers, trihydroxy sodium oxo-cholanyl glycines, polyoxethylene sorbitan ethers, alkyl-aryl polyether alcohols, hyaluronic acidl and pharmaceutically suitable salts thereof, monoolein, triolein, lysine, polylysine, oleic acid, linoleic acid, linolenic acid, monooleates and laurates, glycolic acid, lactic acid, chenodeoxycholate, deoxycholate, chamomile extract, cucumber extract, borage oil and evening primrose oil and mixtures thereof, in an amount of from 1-50 wt./wt. % of the intermediate formulation, and wherein the total concentration of first, second and third ingredients is less than 90 wt.lwt. % of the intermediate formulation.