Patent ID: 6566532
Filing Date: 2003-05-20
Classification: C07D

Abstract:
A process for producing an optically active imidazolidin-2-one of formula (4): wherein R21 and R3 represents the same meanings as described below,which comprises reacting a cyclic acid anhydride of formula (5): wherein R21 representsan alkyl group optionally subtituted with an alkoxy group or a halogen atom, an aralkyl group optionally substituted with an alkyl group, an alkoxy group or a halogen atom, an aryl group optionally substituted with an alkyl group, an alkoxy group or a halogen atom, with a hydroxy compound of formula (3): R3OH â€ƒâ€ƒ(3) wherein R3 represnts an alkyl group optionally substituted with an alkoxy group, a phenoxy group, a dialkylamino group or a halogen atom, an aralkyl group optionally substituted with an alkyl group, an alkoxy group, a phenoxy group, a nitro group or a halogen atom, an aryl group optionally substituted with an alkyl group, an alkoxy group, a nitro group or a halogen atom, in the presence of a catalytic amount of an optically active alkaloid selected from quinine, epiqunine, cinconine and cinconidine.