Patent ID: 6750028
Filing Date: 2004-06-15
Classification: G01N

Abstract:
A method for identifying modulators of scar formation, comprising the steps of:(a) incubating immortalized, non-cancerous macrophages with an exogenous source of latent TGF-&bgr;1 and a modulator compound that modulates latent TBF-&bgr;1 activation; (b) measuring the amount of active TGF-&bgr;1 produced by the macrophages; and (c) comparing the measured amount of active TGF-&bgr;1 produced in step (b) with a control, the control being the measured amount of active TGF-&bgr;1 produced by the incubation of step (a) without the modulator compound of step (a) in order to identify the modulator compound's propensity for scar formation.