Patent ID: 8635029
Filing Date: 2014-01-21
Classification: G16B

Abstract:
1. A method for modifying a biopolymer of interest, the method comprising: a) identifying a plurality of positions in said biopolymer of interest and, for each respective position in said plurality of positions, one or more substitutions for the respective position, wherein the plurality of positions and the one or more substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space; b) selecting a first plurality of variants of said biopolymer of interest thereby forming a first variant set, wherein said first variant set comprises a first subset of said biopolymer sequence space; c) measuring a property of all or a portion of the variants in said first variant set; d) modeling, using a suitably programmed computer, a sequence-activity relationship on a computer between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the first variant set described as a plurality of descriptors x and a plurality of weights w, each weight w i) optimizing, using a suitably programmed computer, the sequence-activity relationship by adjusting individual weights w ii) repeating the optimizing i) a plurality of times thereby obtaining, for each respective descriptor x e) defining a second variant set for the biopolymer of interest, wherein