Patent ID: 6277822
Filing Date: 2001-08-21
Classification: A61K,A61P,C07K

Abstract:
An isolated DNA fragment comprising a sequence coding for a peptide comprising an amino acid sequence which:a. contains at least 8 cysteines which, when the peptide adopts its folded conformation, are linked through 4 disulfide bridges according to the arrangement Cys.sup.1 with Cys.sup.3, Cys.sup.2 with Cys.sup.4, Cys.sup.5 with Cys.sup.6 and Cys.sup.7 with Cys.sup.8 ;b. contains 0 to 3 amino acids on the N-terminal side of Cys.sup.1, 9 to 14 amino acids between Cys.sup.1 and Cys.sup.2 , 3 to 7 amino acids between Cys.sup.2 and Cys.sup.3, 11 to 18 amino acids between Cys.sup.3 and Cys.sup.4, 1 to 6 amino acids between Cys.sup.4 and Cys.sup.5, 7 to 15 amino acids between Cys.sup.5 and Cys.sup.6, no amino acid between Cys.sup.6 and Cys.sup.7, 3 to 5 amino acids between Cys.sup.7 and Cys.sup.8 and 0 to 10 amino acids on the C-terminal side of Cys.sup.8 ; andc. displays an identity of amino acids, after alignment, of at least 40% with the amino acid sequence identified under the number SEQ ID NO: 3,or a fragment thereof.