Patent ID: 6521606
Filing Date: 2003-02-18
Classification: A61K,A61P,C07F

Abstract:
A compound of the general formula I wherein Y is O or S; n is 1, 2, 3 or 4; X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R1 is wherein E, when present represents, a bond or methylene or ethylene, optionally substituted with halogen, hydroxy, cyano, nitro, (C1-6)alkyl, haloalkyl, carboxy, amino, alkylamino, hydroxyalkyl, (C1-6)alkoxy or alkylcarbonyl; s and t are independently 0, 1, 2 or 3; A and Aâ€² independently represent a bond, or a saturated or unsaturated cyclic or heterocyclic hydrocarbon di- or triradical, optionally substituted with (C1-6)alkoxy, (C1-6)alkyl, phenyl, hydroxy, thio, C1-6alkylthio, amino, halogen, cyano, cyanomethyl, trifluoromethyl, nitro, carboxy, â€”CONH2, haloalkyl, alkylamino, hydroxyalkyl, alkylcarbonyl, â€”CONHR12 or â€”CONR12R12 wherein R12 is a (C1-6)alkyl group or the residue of a natural &agr;-amino acid; Z represents a bond, O, S, C(O), C(O)NR7, NR7C(O) or NR7, wherein R7 is hydrogen, hydroxy, branched or straight, saturated or unsaturated hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, haloalkyl carboxy, amino, alkylamino, hydroxyalkyl, alkoxy or alkylcarbonyl R5 represents a bond, alkane or alkene diradical, one or more ether diradicals (Râ€”Oâ€”Râ€²) or amine diradicals (Râ€”Nâ€”Râ€²), wherein R and Râ€² independently represent alkane or alkene diradicals with a C-content from 0 to 3; R6 represents hydrogen, hydroxy, halogen, cyano, nitro, branched or straight, saturated or unsaturated hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, haloalkyl, amino, alkylamino, carboxy, hydroxyalkyl, alkoxy or alkylcarbonyl; NR8R9, C(O)NR8R9, C(O)R8, C(O)OR8, S(O)2R9, wherein each R8 and R9 independently represent hydrogen, halogen, a branched or straight, saturated or unsaturated hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, haloalkyl, hydroxyalkyl, alkoxy or alkylcarbonyl; R2 represents hydrogen, (C1-8)alkyl, (C2-6)alkenyl, (C3-8)cycloalkyl, aryl(C0-6)alkyl or heteroaryl(C0-6)alkyl; provided that when A, Aâ€², Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is not hydrogen; or a salt, hydrate or solvate thereof.