Patent ID: 6274593
Filing Date: 2001-08-14
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR12##wherein:R.sup.1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, arylC.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkoxyC.sub.1-4 alkyl, C.sub.3-6 cycloalkylC.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkylsulphonyl, C.sub.1-4 alkylsulphonyloxy, C.sub.1-4 alkylsulphonylC.sub.1-4 alkyl, arylsulphonyl, arylsulphonyloxy, arylsulphonylC.sub.1-4 alkyl, C.sub.1-4 alkylsulphonamido, C.sub.1-4 alkylamido, C.sub.1-4 alkylsulphonamidoC.sub.1-4 alkyl, C.sub.1-4 alkylamidoC.sub.1-4 alkyl, arylsulphonamido, arylcarboxamido, arylsulphonamidoC.sub.1-4 alkyl, arylcarboxamidoC.sub.1-4 alkyl, aroyl, aroylC.sub.1-4 alkyl, or arylC.sub.1-4 alkanoyl group; a group R.sup.3 OCO(CH.sub.2).sub.p, R.sup.3 CON(R.sup.4)(CH.sub.2).sub.p, R.sup.3 R.sup.4 NCO(CH.sub.2).sub.p or R.sup.3 R.sup.4 NSO.sub.2 (CH.sub.2).sub.p where each of R.sup.3 and R.sup.4 independently represents a hydrogen atom or a C.sub.1-4 alkyl group or R.sup.3 R.sup.4 forms part of a C.sub.3-6 azacyloalkane or C.sub.3-6 (2-oxo)azacycloalkane ring and p represents zero or an integer from 1 to 4; or a group Ar.sup.3 --Z, wherein Ar.sup.3 represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring and Z represents a bond, O, S, or CH.sub.2 ;R.sup.2 represents a hydrogen atom or a C.sub.1-4 alkyl group;X represents a group of the formula (a) or (b): ##STR13##whereinAr and Ar.sup.1 each independently represent an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; andY represents a bond, --NHCO--, --CONH--, --CH.sub.2 --, or --(CH.sub.2).sub.m Y.sup.1 (CH.sub.2).sub.n --, wherein Y.sup.1 represents O, S, SO.sub.2, or CO and m and n each represent zero or 1 such that the sum of m+n is zero or 1;Ar.sup.2 represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system;or a salt thereof.