Patent ID: 7326714
Filing Date: 2008-02-05
Classification: A61P,C07D

Abstract:
1. A method for preventing elevated plasma levels of inflammatory cytokines in humans and higher mammals wherein said cytokines are chosen from TNF-α, IL-1β, and IL-6, thereby controlling or treating congestive heart failure in humans and higher mammals, said method comprising the step of administering to said humans or higher mammals a pharmaceutical composition comprising one or more of the compounds, including all enantiomeric and diasteriomeric forms or a pharmaceutically acceptable salt thereof, having the formula: wherein R is: a) —O[CH b) —NR R R a) hydrogen; or b) —[C(R each R R a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; each R a) hydrogen; b) —(CH c) —(CH d) —(CH e) —(CH f) —(CH g) —(CH h) two R i) and mixtures thereof; R Z is O, S, NR