Patent ID: 6100262
Filing Date: 2000-08-08
Classification: A61P,C07D

Abstract:
A compound having the formula2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or aryl; 1-piperazinyl; 1-piperazinyl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di (C.sub.1-6 alkyl)amino or aryl; hexahydro-1H-diazepin-1-yl or hexahydro-1H-diazepin-1-yl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di (C.sub.1-6 alkyl)amino or aryl;R.sup.5 and R.sup.7 each independently are hydrogen; C.sub.1-6 alkyl; C.sub.1-6 alkyloxy; amino; mono- or di(C.sub.1-6 alkyl)amino; 1-piperidinyl; 1-piperidinyl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or aryl; 1-pyrrolidinyl; 1-pyrrolidinyl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di (C.sub.1-6 alkyl)amino or aryl; 1-piperazinyl; 1-piperazinyl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or aryl; hexahydro-1H-diazepin-1-yl or hexahydro-1H-diazepin-1-yl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, amino, mono- or di(C.sub.1-6 alkyl)amino or aryl;R.sup.6 is hydrogen or C.sub.1-6 alkyl; andaryl is phenyl or phenyl substituted with 1, 2 or 3 substituents selected from halo, C.sub.1-6 alkyl or C.sub.1-6 alkyloxy, ##STR6## a N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, whereinR.sup.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl;R.sup.2 is hydrogen, halo or C.sub.1-6 alkylsulfonylamino;R.sup.3 is hydrogen or C.sub.1-6 alkyl;a radical of formula ##STR7## wherein each Alk independently is C.sub.1-12 alkanediyl;R.sup.4 is hydrogen; hydroxy; C.sub.1-6 alkyl; C.sub.1-6 alkyloxy, amino; mono- or di(C.sub.1-6 alkyl)amino; 1-piperidinyl; 1-piperidinyl substituted with 1 or 2 substituents selected from C.sub.1-6 alkyl, c.sub.1-6 alkyloxy, amuno, mono- or di(C.sub.1-6 alkyl)amino or aryl; 1-pyrrolidinyl; 1 pyrrolidinyl substituted with 1 or with the proviso that R.sup.4 is other than C.sub.1-6 alkyloxy when R.sup.2 is halo.