Patent ID: 7524887
Filing Date: 2009-04-28
Classification: A61K

Abstract:
1. A method for the treatment of acute pain, said method comprising administering to a patient in need thereof an effective amount of a 2-amino-1,3-propanediol compound of formula I-4 wherein: Ra is a straight- or branched chain alkyl having 12 to 22 carbon atoms, said alkyl chain being unsubstituted or substituted in the chain by a substituent selected from the group consisting of double bonds, triple bonds and hetero atom-containing substituents selected from oxygen, sulfinyl, sulfonyl, sulfur, —N(R6)- where R6 is selected from hydrogen, acyl, alkoxycarbonyl, alkyl and aralkyl: said alkyl chain being optionally further substituted by one or more of acyl, acylamino, alkenyloxy, alkoxy, alkoxycarbonyl, alkoxycarbonylamino, alkylamino, alkylcarbamoyl, alkylthio, alkynyloxy, amino, aralkyloxy, aralkyloxyacyloxy, carboxyl, halogen, hydroxyl, hydroxyimino and nitro; and R2b, R3b, R4b and R5b are the same or different and each is selected from hydrogen, acyl and alkyl; or a pharmaceutically acceptable salt thereof.