Patent ID: 6133253
Filing Date: 2000-10-17
Classification: A61K,C07D

Abstract:
A method of treating or controlling pain humans, comprising administering to a patient in need of treatment thereof a compound of formula IA: ##STR15## or a pharmaceutically acceptable salt thereof, wherein Z, Y, X and the 2-azetidine stereochemistry are, respectively, selected from the group consisting of:H, H, CN (S);H, H, Cl (S);H, H, Cl (R);H, H, Br (R);H, H, F (S);H, H, F (R);H, H, CHF.sub.2 (S);H, H, OMe (R);H, Me, Cl (S);H, Me, Cl (R);H, Et, F (S);H, ethenyl, Cl (S);H, ethenyl, Cl (R);H, ethenyl, F (S);H, ethenyl, F (R);H, ethynyl, Cl (S);H, ethynyl, Cl (R);H, Cl, Cl (S);H, Cl, Cl (R);H, Cl, F (S);H, Br, Me (S);H, Br, Me (R);H, Br, Cl (S);H, Br, Cl (R);H, Br, F (S);H, Br, F (R);H, n-Pr, H (S);H, ethenyl, H (S);H, ethenyl, H (R);H, 3-propenyl, H (S);H, Cl, H (R);H, F, H (S);H, NO.sub.2, H (S);H, OEt, H (S);Cl, H, H (S);Cl, H, H (R);F, H, H (S);F, H, F (S);F, H, Me (S); andF, H, Me (R).