Patent ID: 6201009
Filing Date: 2001-03-13
Classification: A61K

Abstract:
An absorption-enhancing composition for a pantothenic acid derivative, which comprises a pantothenic acid derivative represented by the following general formula (I), a neutral or alcoholic ester, and a nonionic surfactant: ##STR4##whereinR.sup.1 and R.sup.2 are the same or different and each independently represents a hydrogen atom or a hydroxyl-protective group or R.sup.1 and R.sup.2 together represent a hydroxyl-protective group;R.sup.3 represents a saturated or unsaturated, linear, branched or cyclic C.sub.5-25 monovalent aliphatic hydrocarbon group optionally substituted by an aromatic group, or an amino group represented by the formula --N(R.sup.4)R.sup.5 (wherein R.sup.4 represents a saturated or unsaturated, linear, branched or cyclic C.sub.3-25 monovalent aliphatic hydrocarbon group; and R.sup.5 represents a hydrogen atom or a saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon group optionally substituted by an aromatic group);A represents a saturated or unsaturated, linear, branched or cyclic C.sub.2-16 divalent aliphatic hydrocarbon group, divalent aromatic hydrocarbon group or divalent heteroaryl group optionally substituted by an aromatic group;one of X and Y represents an amino group represented by the formula --N(R.sup.6)-- while the other represents --O--, --S-- or an amino group represented by the formula --N(R.sup.7)-- (wherein R.sup.6 and R.sup.7 represent each a hydrogen atom or a lower alkyl group); andn is an integer of from 1 to 4.