Patent ID: 7045361
Filing Date: 2006-05-16
Classification: C12Q,G01N,Y10T

Abstract:
1. A biosensor molecule, the biosensor molecule comprising: an acridine-based fluorophore; a boronate binding moiety that is capable of specifically and reversibly binding a polyhydroxylate analyte in a sample; and a linker moiety that links the fluorophore to the boronate binding moiety, wherein the biosensor molecule is capable of emitting a light signal in the visible to near infrared region of the spectrum that can be correlated to a polyhydroxylate analyte concentration in a sample and further wherein the biosensor molecule comprises a molecule of the formula: wherein: F is an acridine-based fluorophore; R R L Z is nitrogen; R wherein F and Z are capable of being involved in an intramolecular photo-induced electron transfer process that quenches the fluorescence of F in the absence of bound polyhydroxylate analyte.