Patent ID: 6075010
Filing Date: 2000-06-13
Classification: A61K,B82Y,C07D

Abstract:
A small molecule clearing agent having a molecular weight ranging from about 1,000 daltons to about 20,000 daltons which clears in vivo a ligand or anti-ligand containing conjugate from the circulation via a hepatocyte receptor mediated clearance mechanism, wherein said small molecule clearing agent comprises at least the following:(i) a ligand or anti-ligand which provides for binding of the clearing agent to a complementary ligand or anti-ligand containing conjugate which is to be cleared from the circulation; and(ii) at least three terminal hexose residues which hexose residues are directly or indirectly covalently attached and appropriately spaced on the clearing agent molecule to enable such clearing agent to bind a hepatocyte receptor and thereby provide for hepatocyte receptor mediated clearance of the ligand or anti-ligand containing conjugate.