Patent ID: 6602987
Filing Date: 2003-08-05
Classification: A61P,C07C,C07D,G01N

Abstract:
A compound of formula whereinR is â€”N&boxH;N-2-carboxyphenyl; A is (CH2)n, â€”CH(COOH)â€” or â€”CH&boxH;CHâ€”, wherein n is an integer from 0 to 10; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR1, wherein R1 is H, p-nitrophenyl or N-succinimidyl; (iii)CONHâ€”NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; (iv) CONHâ€”[B]â€”NHR3, wherein R3 is H, COOR1, or COâ€”[Bâ€²]-maleimido, wherein R1 is t-butyl, p-nitrophenyl or N-succinimidyl, and B and Bâ€², the same or different, are (CH2)n wherein n is an integer from 2 to 10; (v) CONHâ€”[B]â€”COOR4, wherein B is as defined in (iv) above and R4 is H, C1-C8 alkyl, N-succinimidyl; (iv) CONHâ€”[B]â€”OH, wherein B is as defined in (iv) above; (vii) CONHâ€”[B]â€”CONHâ€”NHR2, wherein B is as defined in (iv) above and R2 is H, COO(t-butyl) or COObenzyl; and (viii) NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl, when A is â€”CH(COOH)â€” and R is â€”N&boxH;N-2-carboxyphenyl.