Patent ID: 6762032
Filing Date: 2004-07-13
Classification: A61K,C07K,G01N,Y10S

Abstract:
A method for assaying a sample of an individual for the indicator of a disease condition selected from the group consisting of MS, a pro-MS immune response, and a combination thereof, the method comprising:(a) admixing an aliquot of sample under biological assay conditions with a combination of two or more affinity ligands, wherein the two or more affinity ligands are selected form the group consisting of an anti-human antibody, an affinity ligand having binding specificity for a sialoadhesin family member, and an affinity ligand having binding specificity for an epitope comprising a terminal alpha 2,6-linked sialic acid, and wherein at least one of the affinity ligands comprises a detection reagent; (b) measuring an amount of the detection reagent, if present, which is bound to the sample in determining a value of a marker in the sample; (c) comparing the value of the marker determined to a comparative reference value; wherein a difference in the value of the marker determined in the sample, when compared to the reference value, comprises an indicator of the presence of the disease condition.