Patent ID: 8889724
Filing Date: 2014-11-18
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating or preventing in a mammalian subject a condition selected from the group consisting of gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, tumor-lysis syndrome, cognitive impairment associated with elevated uric acid, and Plasmodium falciparum -induced inflammation, comprising administering to the subject an amount of a compound represented by Formula XLVI effective to reduce the uric acid concentration in blood of, or increase uric acid excretion from, the subject wherein x is 1 or 2; y is 0, 1, 2 or 3; R A is phenyl, unsubstituted or substituted by one, two or three groups selected from the group consisting of halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or