Patent ID: 7563442
Filing Date: 2009-07-21
Classification: A01K,A61K,A61N,A61P,C07K

Abstract:
1. A monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein said antibody comprises: (a) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 2; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 4; (b) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 90; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 4; (c) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 92; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 4; (d) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 2; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 94; (e) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 90; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 94; or (f) a heavy chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 26-35, 50-66, and 99-115 of SEQ ID NO: 92; and a light chain CDR1 amino acid sequence, CDR2 amino acid sequence, and CDR3 amino acid sequence, respectively, of amino acid residues 24-39, 55-61, and 94-102 of SEQ ID NO: 94.