Patent ID: 7358087
Filing Date: 2008-04-15
Classification: A61K,A61P,C07K

Abstract:
1. A method for activating an antigen presenting cell for inducing an enhanced immune response to an immunogen; said immunogen being delivered to the antigen presenting pathway of said antigen presenting cell; said method comprising binding to a characteristic determinant of said antigen presenting cell, a molecular adjuvant comprising a targeting ligand having binding affinity for a characteristic determinant of said antigen presenting cell; said targeting ligand being covalently linked to said immunogen; said characteristic determinant being selected from the group consisting of C5a receptor and IFNγ receptor; whereby binding of said molecular adjuvant effects delivery of said immunogen to said antigen presenting pathway of said antigen presenting cell; wherein the targeting ligand having binding affinity for said C5a receptor is selected from the group consisting of C5a, the C-terminal ten residues of C5a, and a peptide agonist analog of the C-terminal ten residues of C5a; and wherein the targeting ligand having binding affinity for said IFNγ receptor is selected from the group consisting of IFNγ and a peptide comprising the N-terminal 39 residues of INFγ.