Patent ID: 7910059
Filing Date: 2011-03-22
Classification: A61K,C07D,G01N,Y10T

Abstract:
1. A kit comprising an active ester compound that is a 6 or 7 membered heterocyclic ring comprising a ring nitrogen atom that is N-alkylated with a substituted or unsubstituted acetic acid moiety to which the alcohol moiety of the active ester is linked through the carbonyl carbon of the N-alkyl acetic acid moiety, wherein the compound is isotopically enriched with one or more heavy atom isotopes and further comprising one or more reagents, containers, enzymes, buffers or instructions; wherein the compound has the formula: wherein; a) RG is a reactive group that is an electrophile; b) Z is O, S, NH or NR c) each J is the same or different and is selected from the group consisting of: H, deuterium (D), R d) W is an atom or group that is located ortho, meta or para to the ring nitrogen and is selected from the group consisting of: NH, N—R e) each carbon of the heterocyclic ring has the formula CJ f) each R g) R