Patent ID: 6683088
Filing Date: 2004-01-27
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of the formula (I): wherein:X is â€”CHR5â€”, â€”CHR5-alkyl-, or â€”CHR5-alkenyl-; R1 is selected from the group consisting of: â€”R4â€”NR3â€”SO2â€”R6-alkyl; â€”R4â€”NR3â€”SO2â€”R6-alkenyl; â€”R4â€”NR3â€”SO2â€”R6-aryl; â€”R4â€”NR3â€”SO2-R6-heteroaryl; â€”R4â€”NR3â€”SO2-R6-heterocyclyl; â€”R4â€”NR3â€”SO2-R7; â€”R4â€”NR3â€”SO2â€”NR5â€”R6-alkyl; â€”R4â€”NR3â€”SO2â€”NR5â€”R6-alkenyl; â€”R4â€”NR3â€”SO2â€”NR5â€”R6-aryl; â€”R4â€”NR3â€”SO2â€”NR5â€”R6-heteroaryl; â€”R4â€”NR3â€”SO2â€”NRsâ€”R6-heterocyclyl; and â€”R4â€”NR3â€”SO2â€”NH2; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -alkyl-Y-alkyl; -alkyl-Y-alkenyl; -alkyl-Y-aryl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R5)2; â€”COâ€”N(R5)2; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -heteroaryl; -heterocyclyl; â€”CO-aryl; and â€”CO-heteroaryl; Y is â€”Oâ€” or â€”S(O)0-2â€”; R3 is H, C1-10 alkyl, or arylalkyl; each R4 is independently alkyl or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; or R3 is C1-10 alkyl R3 and R4 can join together to form a piperidine ring; each R5 is independently H, C1-10 alkyl, or C2-10 alkenyl; R6 is a bond, alkyl, or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; R7 is C1-10 alkyl; or R3 and R7 can join together to form a 5-membered heterocyclic ring; n is 0 to 4; and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, hydroxy, halogen and trifluoromethyl; or a pharmaceutically acceptable salt thereof.