Patent ID: 7041835
Filing Date: 2006-05-09
Classification: A61K,A61P,C07D

Abstract:
1. A method for obtaining (−)-I-(3,4-dichlorophenyl)-3-azabicyclo[3. 1.0]hexane substantially free of its corresponding (+) enantiomer, comprising the steps of: (a) passing a solution of an organic eluent which comprises a hydrocarbon solvent adjusted in polarity with a miscible polar organic solvent and (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3 .1.0]hexane over a chiral polysaccharide stationary phase to provide a first fraction containing (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3 .1.0]hexane; and (b) passing the first fraction over the chiral polysaccharide stationary phase to provide a second fraction containing (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane substantially free of its corresponding (+)-enantiomer wherein the solvent comprises hexane, isopropylamine and diethylamine.