Patent ID: 9193969
Filing Date: 2015-11-24
Classification: A61K,A61P,C07D,C12N

Abstract:
1. A conjugate comprising at least one selectivity agent which binds specifically to at least one neurotransmitter transporter and is covalently coupled to at least one nucleic acid which is capable of specifically binding to a mRNA encoding a polypeptide which is expressed in the same cell as the neurotransmitter transporter or to said polypeptide itself, and wherein the covalent coupling is either direct or via a linker, and wherein the selectivity agent is selected from the group consisting of a dopamine reuptake inhibitor (DRI), a selective serotonin reuptake inhibitor (SSRI), a noradrenaline reuptake inhibitor (NRI), a norepinephrine-dopamine reuptake inhibitor (NDRI), and a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).