Patent ID: 8282937
Filing Date: 2012-10-09
Classification: A61K,C07K,C12N

Abstract:
1. A reassortant influenza virus comprising: first and second polynucleotides encoding surface proteins HA and NA, respectively, of at least one wild type influenza virus; and third, fourth, fifth, six, seventh, eighth polynucleotides encoding six internal proteins of a cold-adapted influenza virus, wherein the third polynucleotide encodes influenza PB1, wherein the fourth polynucleotide encodes influenza PB2, wherein the fifth polynucleotide encodes influenza PA, wherein the sixth polynucleotide encodes influenza NP, wherein the seventh polynucleotide encodes influenza M, and wherein the eighth polynucleotide encodes influenza NS and wherein the fifth polynucleotide comprises the nucleotide sequence of SEQ ID NO:11 and the fourth polynucleotide comprises the nucleotide sequence of SEQ ID NO: 15.