Patent ID: 8802133
Filing Date: 2014-08-12
Classification: A61K,A61L,A61P,A61Q,Y10S

Abstract:
1. A spreadable preparation for aiding in wound healing and improving the characteristics of the post-epithelialially developed tissue at a wound site, the preparation comprising: a) a volatile component; b) siloxane matrix precursors capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component and comprising an amount ranging from 25 wt % to 60 wt % of the overall spreadable preparation; c) an active component having low miscibility and low solubility in the siloxane matrix precursors; and d) a volatile coagent, the volatile coagent including at least one selected from the group consisting of dimethyl isosorbide, isopropyl myristate, pentylene glycol, and isopropyl myristate; wherein: the volatile coagent being capable of forming a complex with the active component to form a solubilized active component; the complex being miscible in said siloxane matrix precursors; the active component being mobile within a siloxane matrix such that the active component can move to the wound site; the active component being a steroid compound in an amount ranging from 0.5 wt % to 3.0 wt % of the overall composition or an agent having sun screening activity, the agent having sun screening activity comprising octinoxate (ISP escalol 557) and octisalate (ISP escalol 587); and at least a portion of the volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.