Patent ID: 6576663
Filing Date: 2003-06-10
Classification: A61K,A61P,C07C

Abstract:
A method for the treatment of dry eye which comprises administering to a mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of one or more compounds of the following formula I: wherein:R1 is (CH2)pCO2R, (CH2)pOR2, (CH2)pCOT, or (CH2)pT, where: R is H or pharmaceutically acceptable cationic salt moiety, or CO2R forms a pharmaceutically acceptable ester moiety; OR2 forms a free or functionally modified hydroxy group; T comprises a free or functionally modified amino group; and p is 0 or 2; Q9 and Q11 form a free or functionally modified hydroxy group; Xâ€”Y is CH2CH2, trans-CH&boxH;CH, or Câ‰¡C; one of A, B is H and the other comprises a free or functionally modified hydroxy group, or A-B together are the oxygen of a carbonyl group; and D is cycloalkyl, C5-8 alkyl, (CH2)qAr or (CH2)qOAr; where q is 1-6; and Ar is a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; or D is (CH2)pAr1; where p is 0-6; and â€ƒwherein: W is CH2, O, S(O)m, NR10, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)m, CH&boxH;N, or CH2NR10; where m is 0-2, and R10 is H, alkyl, or acyl; Z is H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and is single or double bond.