Patent ID: 7323179
Filing Date: 2008-01-29
Classification: A61K,A61P,C07K

Abstract:
1. A method of preventing or treating a bacterial infection caused by any bacterial species in which RNAIII-activating protein (RAP) plays a role in pathogenesis in a subject, said bacterial species being selected from the group consisting of a staphylococcus bacteria, Bacillus subtilis, Bacillus anthracis, Bacillus cereus, Listeria innocua, Listeria monocytogenes, Streptococcus pyogenes, Lactocococcus lactis, Enterococcus faecalis, Escherichia coli and Clostrydium acetobtylicum , comprising: administering to the subject having or at risk of a bacterial infection caused by a bacteria in which RAP plays a role in pathogenesis an amount of RNAIII inhibiting peptide (RIP) effective to treat or prevent the bacterial infection, wherein the RIP comprises the amino acid sequence set forth in SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:25, SEQ ID NO: 27, or SEQ ID NO:28.