Patent ID: 6326510
Filing Date: 2001-12-04
Classification: A61K,A61P,A61Q,C07C

Abstract:
A biaromatic compound corresponding to formula (I): ##STR7##wherein R.sub.1 is selected from:(i) the radical --CH.sub.3(ii) the radical --CH.sub.2 --O--R.sub.5(iii) the radical --O--R.sub.5, or(iv) the radical --CO--R.sub.6wherein R.sub.5 and R.sub.6 have the meanings given below;Y is selected from the radicals of formulae (a) to (c) below: ##STR8##wherein R.sub.7, R'.sub.7 and n have the meanings given below;Ar is selected from the radicals of formulae (d) to (g) below: ##STR9##wherein R.sub.8 has the meaning given below;X is selected from the radicals of formulae (h), (j), (k), (l), (n), (o) or (p) below: ##STR10##wherein, when X is the radical of formula (n), Y cannot be the radical of formula (a), and R.sub.7, R'.sub.7 and R.sub.9 have the meanings given below;R.sub.2 and R.sub.3, which may be identical or different, is an atom or a radical selected from:(i) a hydrogen atom,(ii) a linear or branched alkyl radical having from 1 to 20 carbon atoms,(iii) a radical --OR.sub.5, or(iv) a radical --SR.sub.5,wherein R.sub.5 has the meaning given below, and at least one of R.sub.2 and R.sub.3 is a radical (ii);wherein R.sub.2 and R.sub.3, taken together, can form, with the adjacent aromatic ring, a 5- or 6-membered ring optionally substituted with methyl groups and/or optionally interrupted by an oxygen or sulphur atom,R.sub.4 and R.sub.8, which may be identical or different, is a hydrogen atom, a halogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms or a radical --OR.sub.5 ;R.sub.5, which may be identical or different, is a hydrogen atom, a lower alkyl radical or a radical --COR.sub.10, wherein R.sub.10 has the meaning given below;R.sub.6 is an atom or a radical selected from:(a) a hydrogen atom,(b) a lower alkyl radical, or(c) a radical of formula: ##STR11##wherein R' and R"" have the meanings given below, or(d) a radical --OR.sub.11,wherein R.sub.11 has the meaning given below;R.sub.7, R'.sub.7, and R.sub.9, which may be identical or different, is a hydrogen atom or a lower alkyl radical;n is equal to 0, 1 or 2;R.sub.10 is a lower alkyl radical;R.sub.11 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, an alkenyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical, or a sugar residue or an amino acid or peptide residue;R' and R"", which may be identical or different, is a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid or peptide or sugar residue, or alternatively, taken together, form a heterocycle; or the optical and geometrical isomers of the compounds of formula (I), or the salts thereof.