Patent ID: 6562823
Filing Date: 2003-05-13
Classification: A61P,C07D

Abstract:
A compound of the formula A: wherein:R1a, R1b, R1c and R1d are independently selected from: a) hydrogen, b) aryl, heterocycle, cycloalkyl, alkenyl, alkynyl, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2Nâ€”C(O)â€”, CN, NO2, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, or R11OC(O)NR10â€”, c) unsubstituted or substituted C1-C6 alkyl wherein the substitutent on the substituted C1-C6 alkyl is selected from unsubstituted or substituted aryl, heterocyclic, cycloalkyl, alkenyl, alkynyl, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2Nâ€”C(O)â€”, CN, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, and R11OC(O)â€”NR10â€”; â€ƒor two R1as, two R1bs, two R1cs or two R1ds, on the same carbon atom may be combined to form â€”(CH2)tâ€”; R2a, R2b, R3a and R3b are independently selected from H; unsubstituted or substituted C1-8 alkyl, unsubstituted or substituted C2-8 alkenyl, unsubstituted or substituted C2-8 alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, or â€ƒwherein the substituted group is substituted with one or more of: 1) aryl or heterocycle, unsubstituted or substituted with: a) C1-4 alkyl, b) (CH2)pOR6, c) (CH2)pNR6R7, d) halogen, e) CN, 2) C3-6 cycloalkyl, 3) OR6, 4) SR4, S(O)R4, SO2R4, R2a and R3a are attached to the same C atom and are combined to form â€”(CH2)uâ€” wherein one of the carbon atoms is optionally replaced by a moiety selected from O, S(O)m, â€”NC(O)â€”, and â€”N(COR10)â€”; and R2a and R3a are optionally attached to the same carbon atom; R4 is selected from C1-4 alkyl, C3-6 cycloalkyl, heterocycle, aryl, unsubstituted or substituted with: a) C1-4alkoxy, b) aryl or heterocycle, c) halogen, d) HO, e) f) â€”SO2R11, g) N(R10)2, or h) C1-4 perfluoroalkyl; R5, R6 and R7 are independently selected from: 1) hydrogen, 2) R10C(O)â€”, or R10OC(O)â€”, and 3) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-6 cycloalkyl, heterocycle, aryl, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, C6-C10 multicyclic alkyl ring, unsubstituted or substituted with one or more substituents selected from: a) R10Oâ€”, b) aryl or heterocycle, c) halogen, d) R10C(O)NR10â€”, e) f) â€”SO2R11, g) N(R10)2, h) C3-6 cycloalkyl, i) C6-C10 multicyclic alkyl ring, j) C1-C6 perfluoroalkyl, k) (R10)2Nâ€”C(NR10)â€”, l) R10OC(O)â€”, m) R11 OC(O)NR10â€”, n) CN, and o) NO2; or R6 and R7 may be joined in a ring; and independently, R5 and R7 may be joined in a ring; R8 is independently selected from: a) hydrogen, b) unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, perfluoroalkyl, F, Cl, Br, R12Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, NO2, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, or R11OC(O)NR10â€”, and c) C1-C6 alkyl unsubstituted or substituted by unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10C(O)NHâ€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, or R10OC(O)NHâ€”; R9 is selected from: a) hydrogen, b) C2-C6 alkenyl, C2-C6 alkynyl, perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, NO2, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, or R11OC(O)NR10â€”, and c) C1-C6 alkyl unsubstituted or substituted by perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, R10C(O)â€”, R10OC(O)â€”, N3, â€”N(R10)2, or R11 OC(O)NR10â€”; R10 is independently selected from hydrogen, C1-C6 alkyl, benzyl, unsubstituted or substituted aryl and unsubstituted or substituted heterocycle; R11 is independently selected from C1-C6 alkyl unsubstituted or substituted aryl and unsubstituted or substituted heterocycle; R12 is independently selected from hydrogen, C1-C6 alkyl, C1-C3 perfluoroalkyl, unsubstituted or substituted benzyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, and C1-C6 alkyl substituted with unsubstituted or substituted aryl or unsubstituted or substituted heterocycle; A1 is O; A2 is a bond; G1, G2 and G3 are independently selected from H2 and O; W is imidazolyl; V is aryl; X and Y are independently selected from a bond and â€”C(&boxH;O)â€”; Z1 is selected from unsubstituted or substituted aryl, wherein the substituted aryl is substituted with one or more of: 1) C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl, unsubstituted or substituted with: a) C1-4alkoxy, b) NR6R7, c) C3-6 cycloalkyl, d) aryl or heterocycle, e) HO, f) â€”S(O)mR4, g) â€”C(O)NR6R7, h) â€”Si(C1-4 alkyl)3, or i) C1-4 perfluoroalkyl; 2) substituted or unsubstituted aryl or substituted or unsubstituted heterocycle, 3) halogen, 4) OR6, 5) NR6R7, 6) CN, 7) NO2, 8) CF3; 9) â€”S(O)mR4, 10) â€”OS(O)2R4, 11) â€”C(O)NR6R7, 12) â€”C(O)OR6, or 13) C3-C6 cycloalkyl; Z2 is a bond; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3 or 4; q is 1 or 2; r is 0 to 5; s is independently 0, 1, 2 or 3; t is 2 to 6; and u is 4 or 5; or a pharmaceutically acceptable salt or stereoisomer thereof.