Patent ID: 6221398
Filing Date: 2001-04-24
Classification: A61K,Y10S

Abstract:
A process for producing a pharmaceutical powder for inhalation, the powder comprising crystalline particles of an inhalation compound selected from the group consisting of salbutamol, terbutaline, rimiterol, fenoterol, reproterol, adrenaline, pirbuterol, isoprenaline, orciprenaline, bitolterol, salmeterol, formoterol, clenbuterol, procaterol, broxaterol, picumeterol, 8-hydroxy-5-(l-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)- 2(1H)-quinoline, mabuterol, betamethasone, fluticasone, budesonide, tipredane, dexamethasone, beclomethasone, fluocinolone, trianicinolone, acetonide, mometasone, rofleponide, and pharmacologically acceptable esters, salts and solvates of these compounds, the particles having a mass median diameter (MMD) of 10 .sub..mu. m or less, the process comprisingdissolving the inhalation compound in a solvent to form a solution; andintroducing the solution containing the inhalation compound, in droplet form or as a jet stream, into an anti-solvent which is miscible with the solvent and which is under agitation, under non-supercritical conditions and at a temperature of less than 25.degree. C., to form the crystalline particles having a MMD of 10 .sub..mu. m or less.