Patent ID: 6156800
Filing Date: 2000-12-05
Classification: A61P,C07C

Abstract:
A benzoylguanidine of the formula I ##STR7## in which: R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --;m is 1 or 2;R(4) and R(5)independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 3, 4, 5 or 6 carbon atoms, CF.sub.3 or --C.sub.n H.sub.2n --R(7);n is zero, 1, 2, 3 or 4;R(6) is H or alkyl having 1, 2, 3 or 4 carbon atoms;R(7) is cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, or phenyl which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9);R(8) and R(9) independently of one anotherare H or alkyl having 1, 2, 3 or 4 carbon atoms;orR(5) is also hydrogen;orR(5) and R(6)together are 4 or 5 methylene groups, of which a CH.sub.2 group can be replaced by oxygen, S, NH, N--CH.sub.3 or N-benzyl;orR(1) is --SR(10); whereinR(10)is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, --C.sub.s H.sub.2s --(C.sub.3 -C.sub.8)-cycloalkyl or an aromatic system selected from the group consisting of pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl or phenyl;s is zero, 1 or 2;where the aromatic systems pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl and phenyl are unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxyl, amino, methylamino and dimethylamino;R(2) is --(CH.sub.2).sub.u --(CF.sub.2).sub.t --CF.sub.3 ;t is zero, 1, 2or 3;u is zero or 1;R(3) is hydrogen or independently defined as R(1);or a pharmaceutically tolerable salt thereof.