Patent ID: 6479507
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A compound selected from the group of compounds represented by Formula (I): wherein:R1 is heteroaryl; ------ represents a bond between B and CR1; B is carbon; R2 is aryl or heteroaryl; and Q is â€”Oâ€”, or â€”Sâ€” wherein: R4 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, acyl, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, heterocyclylcarbonyl, â€”OR5 (where R5 is hydrogen, alkyl, heteroalkyl or heterocyclylalkyl), â€”SO2Râ€³ (where Râ€³ is alkyl, amino, monosubstituted amino or disubstituted amino), â€”CONRâ€²Râ€³ (where Râ€² and Râ€³ independently represent hydrogen, alkyl or heteroalkyl), -(alkylene)-Z or -(alkylene)-CO-(alkylene)-Z wherein: Z is cyano; â€”COOR7 where R7 is hydrogen or alkyl; â€”CONR8R9 where R8 is hydrogen or alkyl, R9 is alkoxy or -(alkylene)-COOR7, or R8 and R9 together with the nitrogen atom to which they are attached form a heterocycle; â€”C(&boxH;NR10)(NR11R12) where R10, R11 and R12 independently represent hydrogen or alkyl, or R10 and R11 together are â€”(CH2)nâ€” where n is 2 or 3 and R12 is hydrogen or alkyl; or â€”COR13 where R13 is alkyl, heteroalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; and â€ƒis a group represented by formula (S); â€ƒwhere: R6 is hydrogen, alkyl, heteroalkyl, heterocyclylalkyl, halo, cyano, nitro, amino, monosubstituted amino, disubstituted amino, â€”COOR14, -(alkylene)-COOR14 (where R14 is hydrogen or alkyl), â€”CONR15R16 (where R15 and R16 independently represent hydrogen or alkyl, or R15 and R16 together with the nitrogen atom to which they are attached form a heterocycle), â€”S(O)nR17 (where n is an integer from 0 to 2 and R17 is alkyl, amino, monosubstituted amino or disubstituted amino), â€”OR18 (where R18 is hydrogen, alkyl, heteroalkyl or heterocyclylalkyl), â€”NRC(O)Râ€³ [where R is hydrogen, alkyl or hydroxyalkyl and Râ€³ is hydrogen, alkyl, cycloalkyl or -(alkylene)-X where X is hydroxy, alkoxy, amino, alkylamino, dialkylamino, heterocyclyl or â€”S(O)nRâ€² (where n is 0 to 2 and Râ€² is alkyl)], â€”NRSO2Râ€³ [where R is hydrogen or alkyl and Râ€³ is alkyl or -(alkylene)-X where X is hydroxy, alkoxy, amino, alkylamino, dialkylamino or â€”S(O)nRâ€² (where n is 0 to 2 and Râ€² is alkyl)]; and R3 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylthio, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, halo, cyano, nitro, amino, monosubstituted amino, disubstituted amino, acylamino, sulfonylamino, â€”OR19 (where R19 is hydrogen, alkyl, heteroalkyl; or heterocyclylalkyl), â€”COOR20 (where R20 is hydrogen or alkyl), â€”CONR21R22 (where R21 and R22 independently represent hydrogen, alkyl or heteroalkyl, or R21 and R22 together with the nitrogen atom to which they are attached form a heterocycle), â€”S(O)nR23 (where n is an integer from 0 to 2 and R23 is alkyl, heteroalkyl, amino, monosubstituted amino or disubstituted amino), -(alkylene)-Zâ€³ or -(alkylene)-CO(alkylene)-Zâ€³ wherein: Zâ€³ is cyano; â€”COOR24 where R24 is hydrogen or alkyl; â€”CONR25R26 where R25 and R26 independently represent hydrogen or alkyl, or R25 and R26 together with the nitrogen atom to which they are attached form a heterocycle; â€”C(&boxH;NR27)(NR28R29) where R27, R28 and R29 independently represent hydrogen or alkyl, or R27 and R28 together are â€”(CH2)nâ€” where n is 2 or 3 and R29 is hydrogen or alkyl; or â€”COR30 where R30 is alkyl, heteroalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; and their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers, provided that both R3 and R6 are not either amino, monosubstituted amino or disubstituted amino.