Patent ID: 6017913
Filing Date: 2000-01-25
Classification: A61K

Abstract:
A method of diagnosing a mammal having amyloid aggregation comprising administering an effective amount of a radiolabeled compound of the formula ##STR15## wherein: R.sup.1 and R.sup.2 independently are hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxy C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, or R.sup.1 and R.sup.2 taken together with the nitrogen to which they are attached complete a heterocyclic ring having from 4 to 12 carbon atoms;n is 1, 2, or 3;R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.4 and R.sup.5 independently are hydrogen, hydroxy, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenoxy, benzyloxy, hydroxy-C.sub.1 -C.sub.4 alkyl, hydroxy-C.sub.1 -C.sub.4 alkoxy, NR.sup.1 R.sup.2, SO.sub.2 NR.sup.1 R.sup.2.sub.1, R.sup.1 R.sup.2 N--CH.sub.2 (CH.sub.2).sub.n --(O or NH).sub.m where R.sup.1, R.sup.2, and n are as defined above, and m is 0 or 1, and R.sup.4 and R.sup.5 when attached to adjacent carbon atoms can be ##STR16## R.sup.6 and R.sup.7 independently are hydrogen, hydroxy, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, or R.sup.1 R.sup.2 N--CH.sub.2 (CH.sub.2).sub.n --(O or NH).sub.m -- where R.sup.1, R.sup.