Patent ID: 7981416
Filing Date: 2011-07-19
Classification: A61K,A61P,C07K

Abstract:
1. A method of inducing proliferative activity of lymphocytes, particularly CD4+ T cells, comprising administering to an individual in need thereof and having an immune deficiency, a pharmaceutical composition comprising an effective amount of a humanized monoclonal antibody comprising the complementarity determining regions (CDRs) of murine monoclonal antibody BAT-1 (mBAT-1) and the framework regions (FRs) from an acceptor human immunoglobulin, or modified therefrom, wherein the humanized antibody retains the activity of mBAT-1 monoclonal antibody and comprises: a light chain variable region selected from the group consisting of: BATRKA (SEQ ID NO: 15), BATRKB (SEQ ID NO: 16), BATRKC (SEQ ID NO: 17), and BATRKD (SEQ ID NO: 18), and a heavy chain variable region selected from the group consisting of: BATRHA (SEQ ID NO: 20), BATRHB (SEQ ID NO: 21), BATRHC (SEQ ID NO: 22), BATRHD (SEQ ID NO: 23) and BATRHE (SEQ ID NO: 24).