Patent ID: 7034154
Filing Date: 2006-04-25
Classification: C07C,C07D

Abstract:
1. A method for making a substituted pyrazolopyrimidine as represented by the following structure: wherein R 7 is phenyl mono-substituted by N-alkyl(C 1 –C 6 )alkanoylamino(C 1 –C 6 ), comprising the following steps: (a) reacting pyrazole 26 with enaminone 25 to yield the corresponding halopyrazolopyrimidine 27, wherein X is halogen (b) reacting halopyrazolopyrimidine 27 with (i) 2-thiophenecarboxylic acid chloride in the presence of zinc or magnesium, or (ii) 2-thiophene boronic acid in the presence of carbon monoxide and a palladium catalyst, to yield the substituted pyrazolopyrimidine.