Patent ID: 6635658
Filing Date: 2003-10-21
Classification: A61P,C07D

Abstract:
Compounds of Formula I: wherein:R1 is (C1-6)alkyl; R2 is halogen or â€”ORâ€²; R3 is hydrogen or â€”ORâ€²; Râ€² is hydrogen, (C1-6)alkyl, or SO2Râ€³; Râ€³ is (C1-6)alkyl, haloalkyl, aryl or heteroaryl, wherein said aryl or heteroaryl groups are optionally substituted with a group selected from (C16)alkyl, halo, haloalkyl, cyano, nitro, alkylsulfonyl, and alkylsulfonylamino; R4 is (i) (C1-6)alkyl, (ii) aryl, heterocyclyl, or heteroaryl, wherein said aryl, heterocyclyl or heteroaryl groups are optionally substituted with a group selected from (C1-6)alkyl, halo, haloalkyl, (C1-6)alkoxy, cyano, amino, mono- or di alkylamino, nitro, alkylsulfonyl, alkylcarbonyl, urea, alkylcarbonylamino, alkylsulfonylamino, alkylaminosulfonyl, alkoxycarbonyl, heterocyclyl and heteroaryl, or (iii) â€”NR5R6; and R5 and R6 are independently of each other hydrogen, (C1-6)alkyl, aryl or heterocyclyl; wherein said aryl or heterocyclyl groups are optionally substituted with (C1-6)alkyl, halo, haloalkyl, cyano, (C1-6)alkoxy, and alkylsulfonyl; or an individual isomer, a racemic or non-racemic mixture of isomers, or an acceptable salt or solvate thereof.