Patent ID: 8211466
Filing Date: 2012-07-03
Classification: A61K,A61P

Abstract:
1. A mucosal bioadhesive slow release carrier formulation comprising (I) at least one antiviral agent, wherein said antiviral agent is: (II) 1% to 75% by weight of microcrystalline cellulose; (III) 2% to 10% by weight of sodium lauryl sulphate; (IV) 0.5% to 5% by weight of polyvinylpyrrolidone; (V) 10% to 40% by weight of natural milk proteins; and (VI) 10% to 40% by weight of hypromellose, said mucosal bioadhesive slow release carrier formulation being obtained by a process comprising the steps of: (a) mixing said at least one antiviral agent with said sodium lauryl sulfate and said microcrystalline cellulose, thereby producing a mixture; (b) wetting said mixture of (a) with said polyvinylpyrrolidone; (c) drying and calibrating said mixture of (b); (d) granulating said mixture of (c) to form primary granules; (e) blending said primary granules with said natural milk proteins and said hypromellose and at least one compression agent; and (f) compressing said blended granules of (e).