Patent ID: 6136819
Filing Date: 2000-10-24
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR161## wherein A is a indolo or thieno group and m is zero;B is the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 is 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -.sub.6)-cycloalkyl(C.sub.1 -.sub.5)alkyl or ##STR162## wherein: R is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, fluorine, chlorine, bromine, iodine, CF.sub.3 or (C.sub.1 -.sub.4)alkoxy,u is 0, 1, 2 or 3, andR.sup.7, R.sup.8, and R.sup.9 independently of one another are methyl, ethyl, propyl, phenyl or benzyl, but not more than two of the substituents can simultaneously be phenyl or benzyl;R.sup.4 is(a) branched or unbranched C.sub.3 -.sub.6 -alkenyl which may be substituted by phenyl, or(b) branched or unbranched C.sub.3 -.sub.6 -alkynyl which may be substituted by phenyl, or(c) branched or unbranched C.sub.1 -.sub.3 -alkyl, wherein the alkyl may be substituted by:(1) hydroxy,(2) (C.sub.1 -.sub.4)alkoxy,(3) di(C.sub.1 -.sub.4)alkylamino,(4) furyl,(5) pyridyl,(6) pyrrolidinyl,(7) N-methylpyrrolidinyl,(8) morpholino,(9) indolyl,(10) nitrilo,(11) thienyl,(12) adamantyl,(13) cyclohexyl,(14) phenyl, phenoxy, or benzyloxy, wherein this phenyl group or the phenyl moiety of this group is optionally substituted by the bridge --O--CH.sub.2 O-- or optionally mono-, di- or trisubstituted by;(a) hydroxy,(b) (C.sub.1 -.sub.4)alkoxy,(c) benzyloxy,(d) fluorine,(e) chlorine,(f) bromine,(g) iodine,(h) CF.sub.3,(i) N.sub.3 ,(j) NO.sub.2,(k) (C.sub.1 -.sub.4)alkyl,(l) adamantyl,(m) --SO.sub.2 NH.sub.2,(n) NHCOCH.sub.3,(o) --NHSO.sub.2 CH.sub.3, or(p) --C(O)O--R.sub.14, wherein R.sub.14 is (C.sub.3 -.sub.7)cycloalkyl or branched or unbranched (C.sub.1 -.sub.6)alkyl, whilst the alkyl is optionally substituted by phenyl, and this phenyl may be mono- to trisubstituted by fluorine, chlorine, bromine, iodine, CF.sub.3, C.sub.1 - or C.sub.2 -alkyl, or C.sub.1 - or C.sub.2 -alkoxy,(15) naphthyloxy, or(16) 2 unsubstituted phenyl groups; or,(d) ##STR163## wherein R.sup.6 is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, fluorine, chlorine, bromine, iodine, CF.sub.3, NO.sub.2 or (C.sub.1 -.sub.4)alkoxy andv is 0, 1, 2 or 3,or the salts thereof with physiologically acceptable acids or complexing agents.