Patent ID: 6156294
Filing Date: 2000-12-05
Classification: A61K,A61P,Y10S

Abstract:
A method of increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance comprising:preparing a mixture of one or more lipids and one or more spreading agents, said lipids and said spreading agents being selected from the group consisting of cholesteryl esters, phospholipids, carbohydrates, and proteins, all in powder form, and one or more fluorocarbon propellants, said lipids and said spreading agents being insoluble in the propellants, and said lipids being present in an amount of about 80 to 99.5 percent by weight and said spreading agents being present in an amount of about 0.5 to about 20 percent by weight, both based upon the total weight of said mixture wherein a mixture of lipid crystals is formed;administering a dose of said mixture of lipid crystals, as an aerosol, through an external nasal orifice of a mammal;whereupon the propellants are evaporated from said mixture as said lipid crystals come into contact with, and deposit upon eustachian tube lumenal tissue and form an amorphous spread film thereupon so as to effectively reduce the opening pressure of said tube.