Patent ID: 6218424
Filing Date: 2001-04-17
Classification: A61K,A61P,C07D

Abstract:
A compound of formula II: ##STR12##or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:n is 1 or 2;X is O or S;Z is selected from the group consisting of CH.sub.2, CHR.sub.1 and CR.sub.1 R.sub.2 ;R.sub.1, R.sub.2, and R.sub.3 are independently selected from the group consisting of C.sub.1 -C.sub.5 straight or branched chain alkyl, C.sub.2 -C.sub.5 straight or branched chain alkenyl, and Ar, wherein said R.sub.1, R.sub.2, or R.sub.3 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, nitro, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy, phenoxy, benzyloxy, amino, and Ar;R.sub.4 is selected from the group consisting of C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, and Ar; provided that when Z is CH.sub.2, R.sub.3 is ethyl, X is O and n is 2, then R.sub.4 is not 1,1 dimethyl propyl and;Ar is an aromatic carbocyclic or heterocyclic group having a single ring or multiple condensed rings in which at least one ring is aromatic and may contain 1-6 heteroatom(s) selected from the group consisting of O, N, and S, wherein said Ar is unsubstituted or substituted with halo, trifluoromethyl, hydroxy, nitro, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy, phenoxy, benzyloxy, or amino.