Patent ID: 6191124
Filing Date: 2001-02-20
Classification: A61P,C07D

Abstract:
A compound of the formula I ##STR68##wherein R.sub.1 is --H or --CH.sub.3 ;wherein R.sub.2 is --H or --CH.sub.3 ; orwherein R.sub.1 and R.sub.2 taken together are ##STR69##wherein p is 1 to 4 inclusive; orwherein R.sub.6 isa) --H,b) --CH.sub.3,c) --F, ord) --OCH.sub.3 ;wherein R.sub.3 isa) --CH.sub.2 C.sub.6 H.sub.5,b) --CH.sub.2 CH.sub.2 C.sub.6 H.sub.5,c) --CH.sub.2 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5,d) --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5,e) --CH.sub.2 CH(CH.sub.3)C.sub.6 H.sub.5,f) --CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 X,wherein X may occupy either the ortho, meta or para-positions and isi) Fii) Cl,iii) Br,iv) OCH.sub.2 R.sub.1,v) N(CH.sub.3).sub.2,vi) NHSO.sub.2 CH.sub.2 R.sub.1,vii) SCH.sub.3viii) NHCOCH.sub.2 R.sub.1, orix) NHSO.sub.2 C.sub.6 H.sub.4 X.sub.1,wherein X.sub.1 isa. H,b. CH.sub.3,c. F, ord. CN;g) --CH.dbd.CH--C.sub.6 H.sub.5, (cis or trans);h) --CH.tbd.C--C.sub.6 H.sub.5);i) CH.dbd.CH--C.sub.6 H.sub.3 X.sub.2wherein X.sub.2 isa. F,b. Cl,c. OCH.sub.3, ord. OCH.sub.2 O; ##STR70##wherein CH.sub.2 CH.sub.2 is appended to the 1- or 2-positions; or ##STR71##whereini) --CH.sub.2 CH.sub.2 -- appended to the 2- or 3-positions,ii) X.sub.3 isa. O,b. S,c. NH,d. NCH.sub.3, andiii) R.sub.7 isa. CH.sub.3, orb. CH.sub.3 CH.sub.2 ;wherein R.sub.4 is --H or --CH.sub.3 ; andwherein R.sub.5 is --H or --CH.sub.3 ;provided that when R.sub.1 is --CH.sub.3 and R.sub.2 is --H or --CH.sub.3, R.sub.4 is not --H.