Patent ID: 7186413
Filing Date: 2007-03-06
Classification: A61K,A61P

Abstract:
1. A water-soluble polymer/drug compound which comprises a water-soluble polymer bonded to a drug or prodrug by an in vivo degradeable covalent bond, wherein the bond is provided by a linking compound having two or more hydrazide groups which react with the polymer and drug to form separate hydrazone bonds to each of the polymer and the drug, and wherein the water-soluble polymer is a poly(vinyl alcohol), an alginate modified to convert at least a portion of its guluronate units to aldehyde guluronate units, a polyamine dendrimer, a poly(ethylene glycol) dendrimer, a poly(allyl amine), a poly(vinyl amine), a polyacrylamide or a polyalkyl(meth)acrylate, wherein the linking compound is adipic acid dihydrazide” after “polyalkyl(meth)acrylate.