Patent ID: 6043030
Filing Date: 2000-03-28
Classification: A01K,C07K,C12N,C12Q,G01N

Abstract:
A diagnostic assay for identifying a cell or cells at risk for a disorder characterized by unwanted cell proliferation or differentiation, in a cell sample, by determining the phenotype of a cell comprising detecting the presence or absence of a genetic lesion characterized by at least one of (i) aberrant modification or mutation of a gene encoding a CDK-inhibitory protein, and (ii) mis-expression of said gene; wherein a wild-type form of said gene encodes a CDK-inhibitory protein and hybridizes under stringent conditions, including a wash step of 2.times.SSC at 50.degree. C., or higher stringency to a nucleic acid selected from the group consisting of SEQ ID No. 1 and SEQ ID No. 3; such that the presence or absence of said genetic lesion identifies a cell or cells at risk of a disorder characterized by unwanted cell proliferation or differentiation.