Patent ID: 8889366
Filing Date: 2014-11-18
Classification: G01N

Abstract:
1. A method for at least one of prediction or risk stratification for at least one of graft failure or mortality of a subject that has received an organ transplant, and monitoring and therapy guidance of such a subject, comprising (a) detecting and quantitating, in a sample taken from said subject, procalcitonin, wherein the level of procalcitonin is detected and quantitated with a diagnostic assay, and (b) comparing the result to a predetermined statistically significant cut-off value range of between 0.0127 ng/mL and 0.1 ng/mL which range is correlated with the prediction or risk stratification for at least one of graft failure or mortality in a subject that has received an organ transplant; with the proviso that the sample is taken from the subject at least one week after transplantation; wherein when the level of procalcitonin in the sample is within the cut-off value range, the subject is predicted or stratified to have an increased risk for at least one of graft failure or mortality; and when the level of procalcitonin in the sample is outside of the cut-off value range, the subject is predicted or stratified to not have an increased risk for at least one of graft failure or mortality; and wherein, in each case, monitoring, therapy or both are indicated in accordance with the prediction or risk stratification or both of graft failure or mortality.