Patent ID: 6096755
Filing Date: 2000-08-01
Classification: A61P,C07D

Abstract:
An N-substituted 3-azabicycloalkane derivative of the formula I ##STR7## where B is a 3-, 5- or 6-membered ring which, in addition to carbon atoms, may contain 1 nitrogen atom and/or 1 oxygen atom and optionally a double bond,R.sup.1 is phenyl which is unsubstituted or mono- or disubstituted by halogen atoms, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups,R.sup.2 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or phenyl which is unsubstituted or substituted by halogen, methoxy, hydroxyl or amino,n is 0, 1, 2, 3, or 4,R.sup.3 is hydrogen, hydroxyl, C.sub.l -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy or, is together with the adjacent carbon atom, a C.dbd.O or C.dbd.S group,one of X and Y is a carbon atom, CH, CH.sub.2, and the other is an NH or C.sub.1 -C.sub.4 -alkyl-N group or a nitrogen atom,Z is a direct bond, andA is C.sub.1 -C.sub.4 -alkylamino, di-C.sub.1 -C.sub.4 -alkylamino, orA is a C.sub.3 -C.sub.4 -akylene group which is linked to Y and which may contain one or two non-cumulative double bonds and where the ring may be monosubstituted either by a fluorine or chlorine atom or a methyl, methoxy, nitro or amino group or, in the case of a benzene ring, the latter may be mono-, di- or trisubstituted by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl- or dimethylamino groups,and where the ring on the right of the formula I may have on nitrogen atom No. 1 a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl group and may contain 1, 2 or 3 non-cumulative double bonds, or a salt thereof with a physiologically tolerated acid.