Patent ID: 7238524
Filing Date: 2007-07-03
Classification: C12N,G01N

Abstract:
1. A method for identifying an agent which modulates expression of biomarkers for prostate cancer progression in neuroendocrine NE-like subclone cells, said cells being selected from the group consisting of ATCC Accession numbers PTA-3568 or PTA-3569, said method comprising the steps of: a) incubating said NE-like subclone cells in the presence and absence of said agent; and b) assaying biomarker expression levels in said NE-like subclone cells, said biomarkers being selected from the group consisting of expressed nucleic acids and proteins, wherein an increase or decrease in expression of the biomarker in cells treated with the agent relative to untreated cells indicates that said agent modulates biomarker expression.