Patent ID: 6800612
Filing Date: 2004-10-05
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
An S-nitrosothiol derivative of penicillamine or glutathione of formula I: or its pharmaceutically acceptable salt thereof, in which:A and B are phenyl groups or together form the group â€”CH2â€”Qâ€”CH2â€” constituting a six membered ring in which Q represents oxygen, sulfur, or a group Nâ€”R3, in which R3 is hydrogen or an alkyl group C1-C4; R1 is an acyl group, which may be an aliphatic C1-C5 acyl group or a glutainic acid acyl group bonded via its gamma carboxyl group; R2 is a hydroxyl group or a glycine group bonded via a peptide bond; with the proviso that if R1 is an aliphatic acyl group, then R2 is a hydroxyl group, and if R1 is a glutamic acid acyl group, then R2 is a glycine group.