Patent ID: 8835171
Filing Date: 2014-09-16
Classification: A61K,A61P,C07K,C12Q,G01N,Y02A

Abstract:
1. A method to affect cholesterol transport in a cell, comprising: administering to the cell a composition of matter comprising an amino acid compound of 17 residues comprising at least ten consecutive amino acid residues of a cholesterol recognition/interaction amino acid sequence and consensus pattern (CRAC) sequence having SEQ ID NO:2, or conservative substitutions of the at least ten consecutive amino acid residues of SEQ ID NO:2, wherein the compound is capable of binding cholesterol and affecting sodium/potassium adenosine triphosphate synthase (Na/K ATPase) cholesterol-binding activity by antagonizing the CRAC domain on an α1 subunit of Na/K ATPase.