Patent ID: 6136838
Filing Date: 2000-10-24
Classification: A61K

Abstract:
A method for controlling ectoparasitic infestation in a companion animal which comprises administering to said animal a therapeutically effective amount of a compound of formula I: ##STR5## wherein R.sup.1 is hydrogen, halogen, or a group NR.sup.4 R.sup.5 ;R.sup.2 is --S(O).sub.n R.sup.6 ;R.sup.3 is --CN or CX--NY.sup.1 .sup.2 ;R.sup.4 and R.sup.5 are independently hydrogen or alkyl;R.sup.6 is haloalkyl;R.sup.7 and R.sup.8 are independently halogen;X is O or S;Y.sup.1 and Y.sup.2 are independently hydrogen, nitro, amino, or alkyl optionally substituted by halogen, cycloalkyl, formyl, C.sub.2-7 alkanoyl, C.sub.4-7 cycloalkylcarbonyl, C.sub.2-7 alkoxycarbonyl, C.sub.2-7 haloalkoxycarbonyl, aryl, or aromatic heterocyclic group; orY.sup.1 and Y.sup.2 together with the nitrogen to which they are attached form an aliphatic heterocyclic group containing from 4 to 8 ring atoms and optionally substituted by halogen or alkyl; orY.sup.1 and Y.sup.2 together form the group.dbd.CHY.sup.3 ; orY.sup.1 is hydrogen and Y.sup.2 is alkoxycarbonyl, alkylcarbonyl, optionally substituted aralkyl, or --S(O)nR.sup.6 ;Y.sup.3 is alkyl, C.sub.2-6 alkenyl, aryl, an aromatic heterocycle, or amino optionally substituted by halogen;n is 0, 1 or 2; ora pharmaceutically acceptable salt thereof.