Patent ID: 6410580
Filing Date: 2002-06-25
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I wherein:W is â€”OH or â€”NHOH; X is an unsubstituted or substituted heterocyclic radical, selected from the group consisting of pyrrolidinyl, pyrrolyl, pyrazolyl, pyrazolinyl, imidazolinyl, imidazolidinyl, oxazolyl, oxazolidinyl, isoxazolinyl, isoxazolyl, thiazolyl, thiadiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, furyl, tetrahydrofuryl, oxadiazolyl, 2-oxopyrrolodinyl, 1,3-dioxolane, tetrahydro-1,1-dioxothienyl, benzothiazolyl, benzoxazolyl, benzimidazolyl, indolizinyl, benzofuryl, indazolyl, pyrrolopyridyl, furopyridinyl and dihydrobenzoisothiazolyl; with the proviso that when X is a nitrogen containing heterocyclic radical, the heterocyclic radical is attached to the (CH2)m moiety by a ring nitrogen and the proviso that nitrogen and sulfur heteroatoms of the heterocyclic radical may also be oxidized; Y is oxygen or sulfur; Z is optionally substituted alkyl; aryl; optionally substituted alkoxy; aryloxy; aralkoxyaryl; aralkoxyheteroaryl; heteroaryl, heterocyclyl, heteroaryloxy, â€”CONRâ€²2Râ€²3, â€”NRâ€²1CORâ€²2, â€”NRâ€²1CONRâ€²2Râ€²3, â€”OCONRâ€²2Râ€²3, â€”NRâ€²1COORâ€²4, or â€”SO2Râ€²2, in which Râ€²1 is hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl or heteroarylalkyl and Râ€²2 and Râ€²3 are independently hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl, heteroarylalkyl, aryl or heteroaryl; or Râ€²2 and Râ€²3 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered ring, which may optionally contain another heteroatom selected from oxygen, nitrogen and sulfur; R4 is optionally substituted alkyl, heterocyclylalkyl, aralkyl, aryl or heteroaryl; m represents an integer from one to six; and n represents the integer one; or a pharmaceutically acceptable salt thereof.