Patent ID: 6159502
Filing Date: 2000-12-12
Classification: A61K,Y10S

Abstract:
A complex for oral delivery of a substance to the circulation or lymphatic drainage system of a host, comprising the substance, a microparticle and a carrier, wherein:said substance is entrapped or encapsulated in said microparticle and therein is not deleteriously affected by intestinal digestive substances following oral administration of said complex to the host;said microparticle is a microsphere or microcapsule having a diameter of 1 nanometer to 150 micrometers and is coupled to said carrier by covalent bond, hydrophobic interaction or both;said carrier is Vitamin B.sub.12 or a Vitamin B.sub.12 -analogue that binds Castle's intrinsic factor and said carrier is effective to transport said complex via the intestinal mucosal epithelium into the circulation or lymphatic drainage system of the host, andsaid substance is released from said microparticle into the circulation or lymph after said complex is transported via the intestinal mucosal epithelium into the circulation or lymphatic drainage system of the host.