Patent ID: 7919628
Filing Date: 2011-04-05
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: R3 and R4 are, independently of one another, hydrogen, F, Cl, or Br; R8 is, independently in each instance, hydrogen, F or Cl; A is cyclohexyl, piperidyl, phenyl, naphthyl, indanyl 2,3-dihydro-benzo[1,4]dioxanyl,benzo[1,3]dioxolyl furyl, thienyl, pyridyl, oxazolyl, isoxazolyl, thiazolyl, imidazolyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxadiazolyl, triazolyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzoxadiazolyl, benzotriazolyl, benzo-1,1-dioxid-thiophenyl or quinolyl; in which cyclohexyl is unsubstituted or substituted by 1, 2 or 3 methyl radicals; in which piperidyl is unsubstituted or substituted by alkyl having 1, 2, 3 or 4 carbon atoms, —C(O)CH in which the aryl or heteroaryl radical is unsubstituted or substituted by 1, 2 or 3 radicals selected from the group consisting of F, Cl, Br, CN, NO B is —O—(CR11R12) R11 is hydrogen; R12 is hydrogen or methyl; D is C(O)OH; R1 and R2 are, independently of one another, alkyl having 1, 2 or 3carbon atoms; or R1 and R2 form, together with the carbon atom to which they are attached, a 3-, 4-, or 5-membered carbon ring; or a pharmaceutically acceptable salt thereof.