Patent ID: 8551965
Filing Date: 2013-10-08
Classification: A61K,A61P,C07D,C07H

Abstract:
1. A compound having the formula: wherein Ar is an aromatic ring system, the aromatic ring system comprising one six-membered aromatic ring and one substituent at the para position on the six-membered aromatic ring and wherein the substituent is selected from the group consisting of unsubstituted aryl, chlorine, and bromine; R Q is selected from the group consisting of O, S and CY X is selected from the group consisting of O, NH, S, N-alkyl, (CH Z is selected from the group consisting of O, S, NH, and N-alkyl; U″ is H and U′ is selected from H and CH wherein: T is selected from the group consisting of OH, H, halogen, O-alkyl, O-acyl, O-aryl, CN, NH T′ is selected from the group consisting of H and halogen and, wherein when more than one T′ is present, they are the same or different; T″ is selected from the group consisting of H and halogen; and W is selected from the group consisting of H, a phosphate group and a pharmacologically acceptable salt thereof; with the provisos that: (1) when T is OAc and T′ and T″ are present and are H, Ar is not 4-(2-benzoxazolyl)phenyl; and (2) when Q, X and Z are each O, and R one six-membered carbocyclic aromatic ring substituted by one or more moieties independently selected from the group consisting of alkyl, aryl, cycloalkyl, chlorine, bromine, iodine, cyano, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio and arylthio, any of which alkyl, cycloalkyl or aryl moieties is substituted by one or more members selected from the group consisting of chlorine, bromine, iodine, CN, CO one six-membered aromatic ring system which contains one, two, three or four hetero atoms and which ring system is optionally substituted; or two fused six-membered aromatic rings, which is optionally substituted.