Patent ID: 8741832
Filing Date: 2014-06-03
Classification: A61K,C07K

Abstract:
1. A method of expanding the volume of plasma in a subject in need thereof comprising administering to the subject a plasma volume expander in an amount effective to expand plasma volume, wherein the plasma volume expander comprises a PEGylated albumin having a colloid osmotic pressure of 37-40 mm Hg and a viscosity of 2.0 to 4.0 cP, wherein the PEGylated albumin comprises 6-18 maleimide phenyl polyethylene glycol (PEG) chains, wherein each PEG chain has a molecular weight of 3,000-20,000 daltons, and wherein each maleimide phenyl polyethylene glycol (PEG) chain is conjugated to a thiolated amino group of albumin.