Patent ID: 6060482
Filing Date: 2000-05-09
Classification: A61P,C07D

Abstract:
Triazaspirodecanone-methylchromans of the general formula ##STR18## in which A, B and D are identical or different and represent hydrogen, halogen, cyano, azido, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxyl or carboxyl, orrepresent straight-chain or branched alkyl, alkenyl, acyl or alkoxycarbonyl each having up to 8 carbon atoms, orrepresent a group of the formula --NR.sup.3 R.sup.4, --NR.sup.5 --L--R.sup.6 or --OR.sup.7,in whichR.sup.3, R.sup.4 and R.sup.5 are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, phenyl or benzyl,L denotes the --CO-- or --SO.sub.2 -- group,R.sup.6 denotes straight-chain or branched alkyl having up to 8 carbon atoms or benzyl, ordenotes aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro, cyano, trifluoromethyl, trifluoromethoxy or by straight-chain or branched alkyl or alkoxy each having up to 6 carbon atoms,R.sup.7 denotes straight-chain or branched alkyl or alkenyl each having up to 8 carbon atoms, each of which is optionally substituted by cycloalkyl having 3 to 6 carbon atoms or phenyl orA has one of the abovementioned meanings andB and D together form a 5- to 7-membered saturated, partially unsaturated or aromatic carbocyclic ring or heterocyclic ring having up to 2 heteroatoms from the series comprising S, N and O, where these rings can optionally have up to 2 carbonyl functions in the ring and are optionally monosubstituted or disubstituted by identical or different substituents from the series comprising straight-chain or branched alkyl or alkoxy each having up to 6 carbon atoms, hydroxyl, cycloalkyl having 3 to 6 carbon atoms, phenyl, halogen, cyano, nitro or in spiro fashion by a radical of the formula ##STR19## in which m denotes a number 1 or 2, andR.sup.1 and R.sup.2 are identical or different and represent hydrogen or straight-chain or branched alkyl, orrepresent phenyl or benzyl, each of which is optionally monosubstituted to trisubstituted by identical or different substituents from the selected from the group consisting of halogen, hydroxyl, cyano, difluoromethyl, difluoromethoxy, trifluoromethyl and trifluoromethoxy or by straight-chain or branched alkyl or alkoxy each having up to 8 carbon atoms,if appropriate in an isomeric form, and their salts.