Patent ID: 6518235
Filing Date: 2003-02-11
Classification: A61K,A61P,C07K

Abstract:
A method for improving memory or treating memory deterioration comprising administering to a patient known to be in need of such improvement or treatment a therapeutic amount of:at least one leptin selected from the group consisting of any one of SEQ. ID. No. 1, SEQ. ID No. 2, SEQ. ID. No. 3, SEQ. ID. No. 4, SEQ. ID. No. 5, and SEQ. ID. No. 6, an analogue which differs by a single conservative amino acid substitution from any one of SEQ. ID. No. 1, SEQ. ID No. 2, SEQ. ID. No. 3, SEQ. ID. No. 4, SEQ. ID. No. 5, and SEQ. ID. No. 6, wherein said analogue is active in a Passive Avoidance Learning Test, at least one leptin that is active in a Passive Avoidance Learning Test and is selected from the group consisting of a leptin having an amino acid homology of at least 99% with any one of SEQ. ID. No. 1, SEQ. ID. No. 2, SEQ. ID. No. 3, SEQ. ID. No. 4, SEQ. ID. No. 5 and SEQ. ID. No. 6, or pharmaceutically acceptable salts thereof.