Patent ID: 8637666
Filing Date: 2014-01-28
Classification: A61P,C07D

Abstract:
1. A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X R each R optionally, R optionally, R optionally, R R R R each J each of J each T is independently halogen, oxo, —NO each Z each Z each Q each Q each J each M is independently halogen, oxo, —NO each R is independently —H or C each R′ is independently —H or C each R″ is independently C each J each J q is 0 or 1; comprising the step of: a) cyclizing a compound represented by Structural Formula (A): under suitable reductive cyclisation conditions to form a compound represented by Structural Formula (B): wherein R 10 is -LG 1 or —X 1 R 1 , and -LG 1 is a suitable leaving group; and b) optionally, when R 10 of Structural Formula (B) is LG 1 , further comprising the step of replacing the -LG 1 with —X 1 (R 1 ) under suitable conditions to form the compound represented by Structural Formula (I).