Patent ID: 6136790
Filing Date: 2000-10-24
Classification: A61P,C07H,C08G

Abstract:
A compound of formula I ##STR30## in which R.sup.1 and R.sup.2 independently of one another are H, CH.sub.2 X or CH.sub.2 O(CH.sub.2).sub.m X.sup.1, wherein X and X.sup.1 independently of one another are H, --NH.sub.2, --COOH, --OH, --CH.sub.2 OH, --CH.sub.2 NH, --(CH.sub.2).sub.r CH.sub.3, aryl, --CH.sub.2 O(CH.sub.2).sub.q H, --CH.sub.2 O(CH.sub.2).sub.q NH.sub.2, --CH.sub.2 O(CH.sub.2).sub.q COOH, --CH.sub.2 O(CH.sub.2).sub.q OH, --CH.sub.2 O(CH.sub.2).sub.q CH.sub.2 OH, --CH.sub.2 O(CH.sub.2).sub.q (CH.sub.2).sub.r CH.sub.3, or --CH.sub.2 O(CH.sub.2).sub.q -Aryl, where r is 0 to 24, or R.sup.1 and R.sup.2 together form a six-membered carbo- or heterocycle which is either unsubstituted or has at least one substituent selected from the group consisting of R.sup.7, R.sup.8 and R.sup.9,R.sup.3 and R.sup.6 together form a six-membered carbo- or heterocycle having at least one substituent X.sup.4,R.sup.4 and R.sup.5 independently of one another are H, OH, CH.sub.2 OH, O(CR.sup.10 R.sup.11).sub.n COOH, OCX.sup.3.sub.2 (CR.sup.10 R.sup.11).sub.n COOH, or OSO.sub.3 H,Y is O-.alpha.-NANA, O-.beta.-NANA, or --O--CH.sub.2 --COOH,Z is a pyranose or a furanose,m, n, and q independently of one another are integers from 1 to 20,R.sup.7, R.sup.8, R.sup.9, and X.sup.4 independently of one another are --NH.sub.2, --COOH, --CH.sub.2 OH, --CH.sub.2 NH, --(CH.sub.2).sub.r CH.sub.3, aryl, --CH.sub.2 O(CH.sub.2).sub.q H, --CH.sub.2 O(CH.sub.2).sub.q NH.sub.2, --CH.sub.2 O(CH.sub.2).sub.q COOH, --CH.sub.2 O(CH.sub.2).sub.q OH, --CH.sub.2 O(CH.sub.2).sub.q CH.sub.2 OH, --CH.sub.2 O(CH.sub.2).sub.q (CH.sub.2).sub.r CH.sub.3, or --CH.sub.2 O(CH.sub.2).sub.q -Aryl, where r is 0 to 24,X.sup.3 is H, --(CH.sub.2).sub.r CH.sub.3, or aryl, or alternativelyX.sup.3.sub.2 is .dbd.O or .dbd.S, andR.sup.10 and R.sup.11 independently of one another are X or --CH.sub.2 X or together form a six-membered carbo- or heterocycle having at least one substituent X.sup.4,wherein said compound is other than the compounds sialyl-Lewis-X and -A and their derivatives, which derivatives, instead of an N-acetyl group, carry the substituents N.sub.3, NH.sub.2 or OH or which derivatives, instead of fucose, carry glycerol.