Patent ID: 6120791
Filing Date: 2000-09-19
Classification: A61K

Abstract:
A co-extrusion process for the production of a controlled release device comprising:(i) supplying a first nozzle orifice of an extrusion apparatus with a first composition and continuously extruding said first composition through said first nozzle orifice to form a continuous extrudate body, said first composition comprising a silicone;(ii) simultaneous with the extrusion of said first composition, supplying a second nozzle orifice situated inside the first nozzle orifice with a second composition and extruding said second composition through said second orifice; and(iii) periodically restricting the extrusion of said second composition so that at least one element of said second composition having a predetermined volume is extruded within the continuous extrudate body, the second composition comprising a synthetic pharmaceutical agent.