Patent ID: 8993719
Filing Date: 2015-03-31
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A KD1 polypeptide comprising: (i) an amino acid sequence with at least 92% identity to SEQ ID NO:3 and in which arginine is present at position 17, (ii) an amino acid sequence with at least 92% identity to SEQ ID NO:3 and in which lysine, histidine or arginine is present at position 17, or (iii) an amino acid sequence with at least 92% identity to SEQ ID NO:3 and in which serine, threonine, asparagine, lysine, histidine or arginine is present at position 17, wherein the KD1 polypeptide inhibits plasmin activity and has decreased anti-coagulation activity as compared to a wild type KD1 polypeptide.