Patent ID: 6306243
Filing Date: 2001-10-23
Classification: A61L,C09J

Abstract:
A method comprising:(a) applying to an in vivo surface a biocompatible composition comprising:(1) at least one monomer which forms a polymer in situ at a physiologic pH; and(2) an effective amount of at least one biocompatible pH modifier to modify the pH of an immediate in vivo environment of said polymer to a pH range at which said polymer biodegrades at a different rate than it does at physiologic pH, without said pH modifier significantly affecting the monomer's polymerization in situ, said at least one biocompatible pH modifier being thoroughly mixed with said at least one monomer; and(b) allowing the monomer composition to polymerize in situ,wherein said pH modifier is in at least one form selected from the group consisting of:(a) insoluble in the monomer,(b) in a microcapsule,(c) chemically protected and insoluble in the monomer,(d) chemically protected and basic,(e) acidic and chemically protected form of at least one member selected from the group consisting of amino acids; di-acids and salts thereof; polyacids and salts thereof; esters that are easily hydrolyzable in vivo; lactones that are easily hydrolyzable in vivo; organic carbonates; enolic compounds; acidic phenols; polyphenolic compounds; aromatic alcohols; boron-containing compounds; sulfonic acids and salts thereof; sulfinic acids and salts thereof; phosphorus-containing compounds; acid halides; chloroformates; acid gases; acid anhydrides; inorganic acids and salts thereof; and polymers having functional groups of at least one member selected from the group consisting of amino acids, di-acids and salts thereof, polyacids and salts thereof, lactones that are easily hydrolyzable in vivo, organic carbonates, enolic compounds, acidic phenols, polyphenolic compounds, aromatic alcohols, boron-containing compounds, sulfonic acids and salts thereof, sulfinic acids and salts thereof, phosphorus-containing compounds, acid halides, chloroformates, acid gases, acid anhydrides, and inorganic acids and salts thereof, and(f) acidic and chemically protected form of at least one member selected from the group consisting of D-galacturonic acid; succinic acid and succinic anhydride; glycolic acid; poly(acrylic acid); acetic acid; diglycolic ahyhdride; citraconic anhydride; maleic anhydride; diethyl oxalate; Meldrum's acid; diethyl carbonate; dipropyl carbonate; diethyl pyrocarbonate; diallyl pyrocarbonate; di-tert-butyl dicarbonate; ascorbic acid; catechin; D-glucosamine hydrochloride; 4-hydroxy-ephedrin hydrochloride; boric acid; nitric acid; hydrochloric acid; sulfuric acid; ethanesulfonic acid; p-toluenesulfonic acid; 2-aminoethylphosphoric acid; methylphosphonic acid; dimethylphosphinic acid; methyl chloroformate; sulfur dioxide; carbon dioxide; and combinations of the above materials.