Patent ID: 6221858
Filing Date: 2001-04-24
Classification: A61K,A61P

Abstract:
A method for relief or prevention of a withdrawal syndrome resulting from addiction to alcohol, nicotine and/or cocaine and/or for the suppression of dependence on alcohol, nicotine and/or cocaine which comprisesadministering an effective amount of a compound of formula (I) ##STR5##or pharmaceutically acceptable acid addition salts thereofwhereinR1 is either halogen or hydrogen and R2 is halogen;X is CH.sub.2, O or S;R3 and R4 are the same or different and are selected from hydrogen or lower alkyl;n is 2 or 3;A is selected from the following pyrimidyl- or pyridyl-groups: ##STR6##whereinR5 is selected from hydrogen, lower alkyl or halogen;R6 and R7 are the same or different and are selected from hydrogen, lower alkyl, halogen, lower alkoxy, hydroxy, cyano, nitro, trifluoromethyl, COOR8, CONR9R10 or COB;whereinR8 is hydrogen or lower alkyl;R9 and R10 are the same or different and are selected from hydrogen, lower alkyl and cycloalkyl;B is selected from ##STR7##whereinm is 1, 2, 3, or 4;R11 is selected from hydrogen or lower alkyl, and when used in the foregoing definitions the term lower alkyl is meant to include straight and branched hydrocarbon groups having from 1 to 5 carbon atoms;cycloalkyl is meant to include cyclohydrocarbon groups having from 3 to 8 carbon atoms;lower alkoxy is meant to include straight and branched alkoxy groups having from 1 to 5 carbon atoms; andhalogen is meant to include F, Cl and Br;and a carrier therefor.