Patent ID: 7374926
Filing Date: 2008-05-20
Classification: C12P

Abstract:
1. A chemoenzymatic enantioconvergent process for the stereoselective preparation of (R)-γ-amino-β-hydroxybutyric acid, which comprises the steps of: (a.) contacting 3-hydroxy-4-trityloxybutanenitrile with a lipase and an acylating agent; (b.) in the presence of said lipase and said acetylating agent, transesterifying the 3-hydroxy-4-trityloxybutanenitrile and obtaining by lipase-mediated kinetic resolution (R)-3-acetyloxy-4-trityloxybutanenitrile and (S)-3-hydroxy-4-trityloxybutanenitrile enantiomers; (c.) transforming the (R)-3-acetyloxy-4-trityloxybutanenitrile enantiomer to (R)-γ-amino-β-hydroxybutyric acid; and, (d.) transforming the (S)-3-hydroxy-4-trityloxybutanenitrile enantiomer to (R)-γ-amino-β-hydroxybutyric acid.