Patent ID: 6541019
Filing Date: 2003-04-01
Classification: A61K

Abstract:
A method for protecting liquid formulations from bacterial contamination, wherein said method comprises adding to said formulations component A):a (per)fluoropolyether phosphate of general formula: Rf- [CF2CH2â€”Oâ€”Lâ€”P(O)(0Z1)(0Z2)]I â€ƒâ€ƒ(I) wherein I=1 or 2; L is a bivalent linking group (CHR1CHR2O), wherein R1, R2 equal to or different from each other are selected from H, CH3; n is an integer in the range 1-50; Z1 equal to or different from Z2 is selected from the group consisting of H, alkaline or ammonium cation, di- or tri-alkanolammonium cation wherein alkanol comprises from 1 to 20 C atoms, di- or tri- or tetra-alkylammonium cation wherein alkyl comprises from 1 to 20 C atoms, or Rfâ€”CF2CH2â€”Oâ€”Lâ€”; Rf represents a (per)fluoropolyether chain having number average molecular weight in the range from about 400 to about 1,800, said (per)fluoropolyether chain comprising repeating units selected from one or more of the following: a) â€”(C3F6O)â€”; b) â€”(CF2CF2O)â€”; c) â€”(CFL0O)â€”, wherein L0=â€”F, â€”CF3; d) â€”CF2(CF2)z'CF2Oâ€”, wherein z'is an integer 1 or 2; e) â€”CH2CF2CF2Oâ€”.