Patent ID: 8709464
Filing Date: 2014-04-29
Classification: A61K,A61L

Abstract:
1. A porous object, comprising: a polymer scaffold having nano-fibrous walls, internal pore surfaces and external pore surfaces; and releasing material encapsulated biomolecules immobilized on at least one of the internal pore surfaces, the external pore surfaces, or combinations thereof; wherein the polymer scaffold is, the releasing material is, or both the polymer scaffold and the releasing material are partially dissolved away where the releasing material encapsulated biomolecules are immobilized, the partial dissolving causing the releasing material encapsulated biomolecules to adhere to the polymer scaffold; wherein the biomolecules are selected from recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-7, recombinant human platelet-derived growth factor BB, tumor necrosis factor-alpha, hepatocyte growth factor, interleukin-8, angiogenin, angiopoietin-1, and combinations thereof, and wherein the releasing material is selected from poly(lactic-co-glycolic acid) and poly(L-lactic acid).