Patent ID: 7981879
Filing Date: 2011-07-19
Classification: A61P,C07D

Abstract:
1. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: R each j is independently an integer equal to zero, 1, or 2; R R R R R R R each R each R R each R R each CycA is independently C CycC independently has the same definition as CycA; each AryA is independently aryl which is optionally substituted with a total of from 1 to 5 substituents, wherein: AryC independently has the same definition as AryA; each HetA is independently a heteroaryl which is optionally substituted with a total of from 1 to 5 substituents, wherein: HetC independently has the same definition as HetA; each CycD is independently a C each AryD is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (25) as set forth above in part (i) of the definition of AryA; each HetD is independently a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein the heteroaromatic ring is optionally substituted with from 1 to 4 substituents each of which is independently halogen, C each aryl is independently (i) phenyl, (ii) a 9- or 10-membered bicyclic, fused carbocyclic ring system in which at least one ring is aromatic, or (iii) an 11- to 14-membered tricyclic, fused carbocyclic ring system in which at least one ring is aromatic; each heteroaryl is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein each N is optionally in the form of an oxide, or (ii) a 9- or 10-membered bicyclic, fused ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein either one or both of the rings contain one or more of the heteroatoms, at least one ring is aromatic, each N is optionally in the form of an oxide, and each S in a ring which is not aromatic is optionally S(O) or S(O)