Patent ID: 6379708
Filing Date: 2002-04-30
Classification: A61K,A61M,A61P,C07K,Y10T

Abstract:
A method of stimulating an immune response in a mammal having a pathological condition, comprising:a. obtaining whole blood from the mammal; b. separating the whole blood into a cellular component and an acellular component or a fraction of the acellular component, wherein said acellular component or said fraction of the acellular component contains a targeted immune system inhibitor selected from the group consisting of soluble receptors for tumor necrosis factors &agr; and &bgr;, interleukin-1 receptor antagonist, soluble receptors for interferon-&ggr;, soluble receptors for interleukin-1, and soluble receptors for interleukin-6; c. contacting the acellular component or said fraction of the acellular component with a binding partner capable of specifically binding to said targeted immune system inhibitor; d. removing the binding partner bound to said targeted immune system inhibitor from said acellular component or said fraction of said acellular component to produce an altered acellular component or altered fraction of the acellular component having a reduced amount of the targeted immune system inhibitor; e. combining the cellular component with the altered acellular component or altered fraction of the acellular component to produce altered whole blood; and f. administering the altered whole blood to the mammal.