Patent ID: 7371852
Filing Date: 2008-05-13
Classification: B01D,B01J,C07H

Abstract:
1. An alkyl-linked nucleotide non-homogeneous solid support consisting essentially of the general formula: wherein Y is a solid support; x=1; R 1 is a covalent bond between Y and R 2 , or R 1 is a divalent acyl group —C(═Q)—, wherein Q is O or NH 2 + ; K is NH; R 7 is (P) n where P is a phosphate or a thiophosphate and n is at least one; and m is at least one; Z is a 5′-nucleosidyl group or a 5′-nucleosidyl group wherein the 5′-nucleosidyl group is not naturally occurring, or a derivative thereof; and —R 2 —K— is selected from the group consisting of: wherein the solid support has a loading of an alkyl-linked nucleotide having a range of about 20% to about 50%.