Patent ID: 8822642
Filing Date: 2014-09-02
Classification: A61K,A61P,C07K

Abstract:
1. A soluble fusion polypeptide comprising, from amino terminus to carboxyl terminus, P1-L1-D-L2-P2 wherein: P1 is a first polypeptide having at least 95% identity with amino acid residues 25-141 of SEQ ID NO:2; L1 is a first polypeptide linker; D is a dimerizing domain; L2 is a second polypeptide linker; P2 is a second polypeptide having at least 95% identity with amino acid residues 25-141 of SEQ ID NO:2; wherein said fusion polypeptide is capable of specifically binding to the extracellular domain of CD155 (amino acid residues 28-343 of SEQ ID NO:22).