Patent ID: 6653094
Filing Date: 2003-11-25
Classification: A61P,C12Q,G01N

Abstract:
A method for identifying a risk for Type 2 diabetes in a human subject, comprising:comparing the level of at least one indicator of altered mitochondrial function in a biological sample from the subject with a control sample; and therefrom identifying the risk for Type 2 diabetes, wherein the indicator of altered mitochondrial function is selected from the group consisting of (i) a Krebs cycle enzyme, wherein said enzyme is an acetyl-coenzyme A carboxylase that is selected from the group consisting of acetyl-coenzyme A carboxylase-1 and acetyl-coenzyme A carboxylase-2, and (ii) an ATP biosynthesis factor, wherein said factor is human acetyl-coenzyme A carboxylase-2.