Patent ID: 6756203
Filing Date: 2004-06-29
Classification: C07K,C12N,C12Q,Y10S

Abstract:
A method for evaluating the presence or degree of a compound's ability to modulate LANA (SEQ ID NO 2) mediated persistence or expression in a cell of a DNA episome having RVCAE (SEQ ID NO 3) comprising:(a) Having cells containing LANA (SEQ ID NO 2) and a persisting DNA episome having RVCAE (SEQ ID NO 3) wherein the presence of the episome is assayed by measurement of episome DNA or episome based expression of a selection or reporter gene; (b) Adding the compound to the medium of some of the cells; and (c) Comparing the results of the assay from cells exposed to the compound against that from cells not exposed to the compound.