Patent ID: 8501817
Filing Date: 2013-08-06
Classification: A61K,A61P

Abstract:
1. A composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier, wherein the non-aqueous vehicle or carrier comprises between about 15% and about 60% by weight of a pharmaceutically acceptable excipient, wherein the Nitrogen Mustard is represented by the following structures: wherein each R 1 , R 2 , R 3 . . . R 34 (R 1 -R 34 ) is independently selected from the group consisting of H, a linear alkyl group having 1-6 carbon atoms, a branched alkyl group having 2-12 carbon atoms, a cycloalkyl group having 3-17 carbon atoms, a fluorinated linear alkyl group having 2-12 carbon atoms, a fluorinated branched alkyl group having 2-12 carbon atoms, a fluorinated cycloalkyl group having 3-17 carbon atoms, aryl groups, aralkyl groups, alkaryl groups, cycloalkyl groups, bicycloalkyl groups, alkenyl groups, alkalkenyl groups, alkenylalkyl groups, alkynyl groups, alkalkynyl groups, alkynylalkyl groups, trifluoropropyl groups, cyanopropyl groups, acryloyl groups, arylacryloyl groups, acryloylaryl groups, alkylacyl groups, arylacyl groups, alkylenylacyl groups and alkynylacyl groups, wherein n is 1-3, wherein p is 0-2, wherein n +P<3, wherein any two R 1 -R 34 in the same molecule may be linked to form a three-to eight-membered cyclic group, wherein the pharmaceutically acceptable excipient is 2-(2-ethoxyethoxy) ethanol, and wherein when the composition is applied topically to the skin, there is no clinically significant systemic absorption of the topically applied Nitrogen Mustard.