Patent ID: 8440176
Filing Date: 2013-05-14
Classification: A61K,A61L,A61P,C08G

Abstract:
1. A graftable polymer having the following structure: wherein (i) each Bio is, independently, one or more biologically active agents or precursors thereof; (ii) C1 is a coupling segment (iii) C2 is a hydrolysable coupling segment or a polyamide linker susceptible to hydrolysis by a peptidase enzyme linking Bio to Bio; (iv) Oligo comprises a repeating monomeric unit or units that number less than 50 monomeric units and has a molecular weight less than 5 KDa; (v) G″ is a grafting moiety that has the following structure: wherein, independently, a. X is either —NH— or —O—; b. m is an integer between 1 and 6; c. n is an integer between 0 and 6; and d. R is an optional substituent selected from —H; —NO wherein each of n, o, and p is independently an integer greater than 0, and wherein G″ is covalently tethered to Bio, C1, C2, or Oligo.