Patent ID: 7723339
Filing Date: 2010-05-25
Classification: A61K,A61P

Abstract:
1. A method of treating a warm-blooded animal having a proliferative disease comprising administering to the animal a combination of (a) N-{5-[4-(4-methyl-piperazino-methyl) -benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine; and (b) an epothilone, of formula I in which A represents O or NR N , wherein R N is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier; for simultaneous, separate or sequential use, in a quantity which is jointly therapeutically effective against a proliferative disease wherein the proliferative disease is selected from the group consisting of glioma and thyroid carcinoma.