Patent ID: 7364881
Filing Date: 2008-04-29
Classification: C12P

Abstract:
1. A process for the production of ortho-aminophenols from nitroarenes, said process comprising: a) providing a recombinant bacteria that expresses both nitroreductase and mutase activities, wherein said recombinant bacteria is an b) incubating said recombinant bacteria strain with a nitroarene; c) reducing said nitroarene to the corresponding hydroxylaminoarene by said nitroreductase; d) converting said hydroxylaminoarene to said ortho-aminophenol by said mutase; and e) recovering a fraction containing said ortho-aminophenol, wherein said ortho-aminophenol is selected from the group consisting of 2-aminophenol, 2-amino-3-methylphenol, 2-amino-4-methylphenol, 4-amino-3-hydroxybenzoate, 4-amino-5-phenoxyphenol, 2-aminonaphthol, 4-amino-3-hydroxy-α,α,α,-trifluorotoluene, 2-amino-3-hydroxyacetophenone, and 3-amino-2-hydroxyacetophenone.