Patent ID: 6476027
Filing Date: 2002-11-05
Classification: C07C,C07D

Abstract:
A compound or a salt thereof, wherein:the compound corresponds in structure to Formula I: R1 is a substituted 5- or 6-membered cyclohydrocarbyl, heterocyclo, aryl, or heteroaryl; the number of non-hydrogen atoms in the longest linear chain of atoms in R1 is greater than 6 and less than about 20 atoms; R1 defines a three-dimensional volume, when rotated about an axis drawn through the SO2-bonded 1-position and the 4-position of a 6-membered ring or drawn through the SO2-bonded 1-position and the center of the 3,4-bond of a 5-membered ring, whose widest dimension in a direction transverse to the axis of rotation is about that of one furanyl ring to about that of two phenyl rings; as to R2 and R3: R1 and R3 are independently selected from the group consisting of hydrido, C1-C4 hydrocarbyl, heteroaryl-C1-C4 hydrocarbyl, aryl-C1-C4 hydrocarbyl, hydroxy-C1-C4 hydrocarbyl, C1-C4 hydrocarbyloxy-C1-C4 hydrocarbyl, aryloxy-C1-C4 hydrocarbyl, amino-C1-C4 hydrocarbyl, C1-C4 hydrocarbylthio-C1-C4 hydrocarbyl, C1-C4 hydrocarbylsulfonyl-C1-C4 hydrocarbyl, aminosulfonylamino-C1-C4 hydrocarbyl, aminocarbonylamino-C1-C4 hydrocarbyl, C1-C4 hydrocarbylcarbonylamino-C1-C4 hydrocarbyl, aryl-C1-C4 hydrocarbyl, heteroaryl-C1-C4 hydrocarbyl, and benzyloxy-C1-C4 hydrocarbyl, except that only one of R2 and R3 may be other than hydrido or C1-C4 hydrocarbyl, or R2 and R3, together with the depicted carbon atom to which they are bonded, form a heterocyclic ring, wherein each heteroatom in the heterocyclic ring is: independently selected from the group consisting of oxygen, sulfur, and nitrogen, when sulfur, optionally substituted with one or two oxygens, and when nitrogen, optionally substituted with a substituent, R5, that is selected from the group consisting of hydrido, C1-C4 hydrocarbyl, C3-C6 cyclohydrocarbyl, C1-C4 hydrocarbylcarbonyl, and C1-C4 hydrocarbyl sulfonyl; as to R6 and R7: R6 and R7 are independently selected from the group consisting of hydrido, C1-C4 hydrocarbyl, heteroaryl-C1-C4 hydrocarbyl, aryl-C1-C4 hydrocarbyl, hydroxy-C1-C4 hydrocarbyl, C1-C4 hydrocarbyloxy-C1-C4 hydrocarbyl, aryloxy-C1-C4 hydrocarbyl, amino-C1-C4 hydrocarbyl, C1-C4 hydrocarbylthio-C1-C4 hydrocarbyl, C1-C4 hydrocarbylsulfonyl-C1-C4 hydrocarbyl, aminosulfonylamino-C1-C4 hydrocarbyl, aminocarbonylamino-C1-C4 hydrocarbyl, C1-C4 hydrocarbylcarbonylamino-C1-C4 hydrocarbyl, aryl-C1-C4 hydrocarbyl, heteroaryl-C1-C4 hydrocarbyl, and benzyloxy-C1-C4 hydrocarbyl, except that only one of R6 and R7 may be other than hydrido or C1-C4 hydrocarbyl, or R6 and R7, together with the depicted carbon atom to which they are bonded, form a heterocyclic ring, wherein each heteroatom in the heterocyclic ring is: independently selected from the group consisting of oxygen, sulfur, and nitrogen, when sulfur, optionally substituted with one or two oxygens, and when nitrogen, optionally substituted with a substituent, R5, that is selected from the group consisting of hydrido, C1-C4 hydrocarbyl, C3-C6 cyclohydrocarbyl, C1-C4 hydrocarbylcarbonyl, and C1-C4 hydrocarbylsulfonyl; and only one of R2, R3, R6, and R7 may be other than hydrido, C1-C4 hydrocarbyl, or a part of a heterocyclic ring structure.