Patent ID: 6194446
Filing Date: 2001-02-27
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I ##STR43##wherein:Q is selected from the group consisting of --(CH.sub.2).sub.p -- and --CH.sub.2 --O--CH.sub.2 --;R.sup.0 is the group ##STR44##R.sup.2 is selected from the group consisting of C.sub.1-4 alkylaminocarbonyl, arylcarbonyl, aryloxycarbonyl, aryloxy C.sub.1-4 arlylcarbonyl, arylaminocarbonyl, aryl C.sub.1-4 acyl, aryl C.sub.1-4 alkoxycarbonyl, aryl C.sub.1-4 alkylaminocarbonyl, aryl C.sub.1-4 akylsulfonyl, and amino-protecting groups;R.sup.3 is hydrogen, or C.sub.1-4 alkyl;R.sup.5 is --COOH, --CONR.sup.10 R.sup.11, --CN, --CONHOH, or ##STR45##R.sup.6 is hydrogen, C.sub.1-4 alkyl, aryl, or aryl C.sub.1-4 alkyl;R.sup.7 is hydrogen, halogen, or C.sub.1-4 alkyl;R.sup.10 or R.sup.11 are independently hydrogen, C.sub.1-4 alkyl, or aryl;W is --(CH.sub.2).sub.n --;Y is attached at position 3 or at position 4, and is --O--;n is 1 to 4; andp is 1, 2, or 3;or a pharmaceutically-acceptable salt thereof;provided that when R.sup.6 is either hydrogen or C.sub.1-4 alkyl, then R.sup.7 is halogen.