Patent ID: 8273708
Filing Date: 2012-09-25
Classification: A61K,A61P

Abstract:
1. A method for reducing paracellular permeability of the ocular epithelium in subjects exposed to at least one preservative agent comprising administering to a mammal in need of such treatment an effective amount of a selective MLCK (Myosin Light Chain Kinase) inhibitor, wherein the selective MLCK inhibitor is selected from the group consisting of {1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine} (ML-7) and 1-(5-chloronaphtalene-1-sulfonyl)homopiperazine-HCl (ML-9), and wherein the at least one preservative agent causes an increase in paracellular permeability of ocular epithelium.