Patent ID: 6262084
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A compound of the structure ##STR17##wherein A is selected from the group consisting of --O--, --S--, and --NR.sup.5 --;E is selected from the group consisting of --CH.sub.2 --, --O--, --S--, and --NR.sup.6 --;Q is selected from the group consisting of --C(O)-- and --(CH.sub.2).sub.k -- wherein k is an integer of 0 or 1;J is selected from the group consisting of --O--, --S-- and --NR.sup.8 --;G is selected from the group consisting of --O--, --NH--, --S--, and --(CH.sub.2).sub.p -- wherein p is an integer of 0 or 1;T is selected from the group consisting of --C(O)-- and --(CH.sub.2).sub.b -- wherein b is an integer of from 0 to 3;L is selected from the group consisting of --O--, --NR.sup.7 --, --S--, and --(CH.sub.2).sub.n -- wherein n is an integer of 0 or 1;B, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of hydrogen halogen, hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, thioalkoxy, aliphatic acyl, --CF.sub.3, nitro, amino, cyano, --N(C.sub.1 -C.sub.3 alkyl)--C(O)(C.sub.1 -C.sub.3 alkyl), --C.sub.1 -C.sub.3 alkylamino, alkenylamino, alkynylamino, di(C.sub.1 -C.sub.3 alkyl)amino, --C(O)O--(C.sub.1 -C.sub.3 alkyl), --C(O)NH--(C.sub.1 -C.sub.3 alkyl), --CH.dbd.NOH, --PO.sub.3 H.sub.2, --OPO.sub.3 H.sub.2, --C(O)N(C.sub.1 -C.sub.3 alkyl).sub.2, haloalkyl, alkoxylcarbonyl, alkoxyalkoxy, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, aroyl, aryloxy, arylamino, biaryl, thioaryl, heterocyclyl, heterocycloyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, sulfonyl, sulfonamido, carbamate, aryloxyalkyl, carboxyl and --C(O)NH(benzyl);R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, aryl, alkylaryl, arylalkyl, heterocyclyl, alkylheterocyclyl, heterocyclylalkyl and alkyl;R.sup.4 is selected from the group consisting of aryl, alkylaryl, arylalkyl, heterocyclyl, alkylheterocyclyl and heterocyclylalkyl;X is --CO.sub.2 B; andM is --C(R.sup.9)(R.sup.10)-- wherein R.sup.9 and R.sup.10 are independently selected from the group consisting of hydrogen and lower alkyl;wherein B, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are unsubstituted or substituted with at least one electron donating or electron withdrawing group;and wherein R.sup.2 and R.sup.3 taken together may form a first ring;R.sup.4 and R.sup.7 taken together may form a second ring;R.sup.9 and R.sup.10 taken together may form a third ring;and pharmaceutically acceptable salts or pro-drugs thereof.