Patent ID: 8404436
Filing Date: 2013-03-26
Classification: A61K,A61P,C07D,C07K,C12Q,G01N

Abstract:
1. A method of identifying a compound that modulates GPR 17 biological activity comprising the steps of (a) contacting a compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I or a salt thereof, (b) measuring the biological activity of said GPR17 or said functional GPR17 fragment after addition of said compound, and (c) comparing the biological activity measured in step (b) with the biological activity of said GPR17 or said functional fragment thereof in the presence of said GPR 17 agonist of formula I without the addition of said compound to identify whether the compound is one that modulates GPR17 activity, wherein in formula I R1 and R2 are independently selected from the group comprising hydrogen, halogen, hydroxy, formyl, oxime, cyano, nitro, amino, NR6R7, carboxy, carbamoyl, (C R3 is selected from hydrogen, a group —(CH R4 is selected from hydrogen and fluoro; R5 is selected from hydrogen, halogen, (C R6 and R7 are independently selected from hydrogen, (C R8 and R9 are independently selected from among hydrogen and (C n and m are independently 0, 1 or 2.