Patent ID: 8936914
Filing Date: 2015-01-20
Classification: G01N,Y10T

Abstract:
1. A method of providing a prognosis for survival for a human subject diagnosed with metastatic renal clear cell carcinoma, comprising: (a) obtaining a sample of a renal tumor or of a metastatic lesion of the renal tumor of the subject; (b) detecting expression of a carbonic anhydrase IX (CAIX) protein of SEQ ID NO:2 in the sample by immunohistochemical staining or immunoassay using an antibody that specifically binds to the CAIX protein of SEQ ID NO:2; (c) quantifying the percentage of the sample that is positive for expression of the CAIX protein; (d) identifying the subject as having a worse prognosis for survival if ≦85% of the sample expresses the CAIX protein or identifying the subject as having a better prognosis for survival if >85% of the sample expresses the CAIX protein; and (e) planning a therapy for the subject according to the prognosis.