Patent ID: 7375222
Filing Date: 2008-05-20
Classification: A61K,A61P,C07D

Abstract:
1. A 2,4,6-triamino-1,3,5-triazine selected from the group consisting of the following compounds or a pharmaceutically acceptable salt thereof: N,N′-diphenyl-N″-(4-pyridylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-diphenyl-N″-(pyridin-3-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-diphenyl-N″-(pyridin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-[(2-fluoropyridin-4-yl)methyl]-N′,N″-diphenyl-1,3,5-triazine-2,4,6-triamine, N-[(2-chloropyridin-4-yl)methyl]-N′,N″-diphenyl-1,3,5-triazine-2,4,6-triamine, N-[(2-isopropylpyridin-4-yl)methyl]-N′,N″-diphenyl-1,3,5-triazine-2,4,6-triamine, N,N′-diphenyl-N″-(2-pyridin-4-ylethyl)-1,3,5-triazine-2,4,6-triamine, N-(3,4-difluorophenyl)-N′-[(2-fluoropyridin-4-yl)methyl]-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N-[(2-fluoropyridin-4-yl)methyl]N′-(4-methoxyphenyl)-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-[(2-fluoropyridin-4-yl)methyl]-N″-(4-methylphenyl)-1,3,5-triazine-2,4,6-triamine, N-[(5-methyl-2-furyl)methyl]-N′,N″-diphenyl-1,3,5-triazine-2,4,6-triamine, N,N′-diphenyl-N″-(2-thienylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(2-furylmethyl)-N′,N″-diphenyl-1,3,5-triazine-2,4,6-triamine, N-(2-furylmethyl)-N′-(4-methylphenyl)-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N,N′-diphenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-(4-methoxyphenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pryidin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pyridin-3-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pyridin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-[(2-fluoropyridin-4-yl)methyl]-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-[(2-fluoropyridin-4-yl)methyl]-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-[(2-methylpyridin-4-yl)methyl]-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N-[(2-fluoropyridin-4-yl)methyl]-N′-(4-methylphenyl)-N″-phenyl-1,3,5-triazine-2,4,6-triamine, {4-[({4-anilino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}amino)methyl]pyridin-2-yl}methanol, N-(4-fluorophenyl)-N′-(2-furylmethyl)-N″-phenyl-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-phenyl-N″-(1,3-thiazol-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pyrimidin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-[(2-fluoropyridin-4-yl)methyl]-N″-(4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine, N-(4-chlorophenyl)-N′-(4-fluorophenyl)-N″-[(2-fluoropyridin-4-yl)methyl]-1,3,5-triazine-2,4,6-triamine, N-(4-chlorophenyl)-N′-[(2-fluoropyridin-4-yl)methyl]-N″-phenyl-1,3,5-triazine-2,4,6-triamine, 3-{[(4,6-dianilino-1,3,5-triazin-2-yl)amino]methyl}dihydrofuran-2(3H)-one, N,N′-bis(4-fluorophenyl)-N′-(2-furylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-(phenyl)-N″-(1,3-thiazol-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-(4-methoxyphenyl)-N″-(pyrimidin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-phenyl-N″-(pyridazin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N,N′-bis(4-fluorophenyl)-N″-(pyridazin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, N-(4-fluorophenyl)-N′-(4-methoxyphenyl)-N″-(pyridazin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine, and N-(4-fluorophenyl)-N′-phenyl-N″-(pyridazin-3-ylmethyl)-1,3,5-triazine-2,4,6-triamine.