Patent ID: 7071317
Filing Date: 2006-07-04
Classification: A61K,C07K

Abstract:
1. A composition comprising an isolated DNA sequence encoding a human recombinant tissue inhibitor of metalloproteinase 3 polypeptide (recombinant TIMP-3 polypepetide) and a pharmaceutically acceptable carrier, wherein the recombinant TIMP-3 polypeptide is: (a) a polypeptide comprising the amino acid sequence 1 to 211 of SEQ ID NO: 13; (b) a polypeptide comprising the amino acid sequence 24 to 211 of SEQ ID NO: 13; (c) a polypeptide comprising the amino acid sequence 24 to 144 of SEQ ID NO: 13 and, optionally, at the C-terminus, all or part of the amino acid sequence 145–211 of SEQ ID NO: 13; or (d) a polypeptide according to (b) or (c) additionally comprising a methionyl residue at position −1.