Patent ID: 6528526
Filing Date: 2003-03-04
Classification: A61P,C07D

Abstract:
A compound of formula I: wherein X is L1; L1 is (CR3aR3b)rH or (CR3aR3b)mâ€”Z3â€”(CR3â€²aR3â€²b)nH; Z1 is CH; Z3 is O, NR4 or SO; m is 0 or 1; n is 2 or 3, and n+m=2 or 3; r is 2, 3 or 4; R1a and R1b are independently alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R5R6Nâ€” or acylR5Nâ€”, or one of R1a and R1b is hydrogen or halo and the other is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R5R6Nâ€” or acylR5Nâ€”; R1c is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, halo, cyano, R5R6Nâ€” or acylR5Nâ€”; R3a, R3b, R3â€²a and R3â€²b are independently hydrogen or alkyl; R4 is hydrogen, alkyl or acyl; and R5 and R6 are independently hydrogen or alkyl, or R5 and R6 taken together with the nitrogen atom to which R5 and R6 are attached form a heterocyclyl, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof.