Patent ID: 7728023
Filing Date: 2010-06-01
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by the formula (I-a-1) wherein: R (1) alkyl which may have a substituent(s), (2) alkenyl which may have a substituent(s), (3) alkynyl which may have a substituent(s), (4) hydroxy which may be protected by alkyl, alkenyl, alkynyl, alkylsulfonyl or acyl, (5) mercapto which may be protected by alkyl, alkenyl, alkynyl, alkylsulfonyl or acyl, (6) amino which may be protected by alkyl, alkenyl, alkynyl, alkylsulfonyl or acyl, (7) carbamoyl which may have a substituent(s), (8) sulfamoyl which may have a substituent(s), (9) carboxy, (10) C1-6 alkoxycarbonyl, (11) sulfo, (12) sulfino, (13) nitro, (14) cyano, (15) halogen, (16) C1-4 alkylsulfinyl, (17) C1-4 alkylsulfonyl, or (18) acyl, wherein said acyl represents R m-1 represents 0 or an integer of 1 to 3; V represents W represents —O—(C1-6 alkylene)—O—, —O—(C2-6 alkenylene)—O—, —O—(C1-6 alkylene)-C(═O)—, —CH ring A represents cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, cyclononane, cyclodecane, cyclopentene, cyclohexene, cycloheptene, cyclooctene, cyclopentadiene, cyclohexadiene, cycloheptadiene, cyclooctadiene, benzene, pentalene, perhydropentalene, azulene, perhydroazulene, indene, perhydroindene, indan, naphthalene, dihydronaphthalene, tetrahydronaphthalene, perhydronaphthalene, pyridine, pyrrole, quinoline, isoquinoline, oxazole, thiazole, benzooxazole or benzothiazole ring, each of which may be substituted with a group(s) selected from the group consisting of C1-8 alkyl which may have a substituent(s), C2-8 alkenyl which may have a substituent(s), C1-8 alkoxy which may have a substituent(s), C2-8 alkenyloxy which may have a substituent(s), C5-10 mono- or bi-cyclic carbocyclic ring which may have a substituent(s), 5 to 10 membered mono- or bi-cyclic heterocyclic ring which may have a substituent(s), hydroxy which may be protected, mercapto which may be protected, amino which may be protected, carbamoyl which may have a substituent(s), carboxy, alkoxycarbonyl, nitro, cyano, halogen, acyl and oxo; ring B represents cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, cyclononane, cyclodecane, cyclopentene, cyclohexene, cycloheptene, cyclooctene, cyclopentadiene, cyclohexadiene, cycloheptadiene, cyclooctadiene, benzene, pentalene, perhydropentalene, azulene, perhydroazulene, indene, perhydroindene, indan, naphthalene, dihydronaphthalene, tetrahydronaphthalene, perhydronaphthalene, pyridine, pyrrole, quinoline, isoquinoline, oxazole, thiazole, benzooxazole or benzothiazole ring, each of which may be substituted with 1 to 3 group(s) selected from the group consisting of hydroxyl, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, halogen, C1-8 alkoxy, C2-8 alkenyloxy, C2-8 alkynyloxy, C1-8 alkylthio, C1-8 acyl, C1-4 alkyl substituted with 1 to 3 halogen(s), C1-4 alkyl substituted with hydroxy, C1-4 alkyl substituted with mercapto, C1-4 alkoxy substituted with 1 to 3 halogen(s); D represents a bond, C1-4 alkylene which may have 1 to 2 substituent(s), —C(O)—(C2-4 alkylene)- which may have 1 to 2 substituent(s), —O—(C1-4 alkylene)- which may have 1 to 2 substituent(s) or —S—(C1-4 alkylene)- which may have 1 to 2 substituent(s), provided that each alkylene group binds to R E represents a bond, C1-4 alkylene which may have 1 to 2 substituent(s), —C(O)—(C2-4 alkylene)- which may have 1 to 2 substituent(s), —O—(C1-4 alkylene)- which may have 1 to 2 substituent(s) or —S—(C1-4 alkylene)- which may have 1 to 2 substituent(s), provided that each alkylene group binds to R R wherein R