Patent ID: 9206223
Filing Date: 2015-12-08
Classification: A61K,A61P,C07K

Abstract:
1. A method for preparing a pharmaceutical composition comprising a purified peptidomimetic macrocycle comprising an alpha-helix, the method comprising: a) contacting a peptidomimetic precursor attached to a solid support comprising at least two moieties capable of undergoing a metathesis reaction with a metathesis catalyst comprising a metal to produce a crude peptidomimetic macrocycle comprising a cross-linker connecting a first amino acid and a second amino acid, the cross-linker spanning from 1 turn to 5 turns of the alpha-helix; b) purifying the crude peptidomimetic macrocycle to result in a purified peptidomimetic macrocycle composition comprising less than 10 ppm by weight of the metal from the metathesis catalyst, wherein said purifying comprises the step of washing said crude peptidomimetic macrocycle with a solvent prior to removing said crude peptidomimetic macrocycle from the solid support; and c) formulating the purified peptidomimetic macrocycle composition into the pharmaceutical composition for administration to a human subject.