Patent ID: 8741297
Filing Date: 2014-06-03
Classification: A23C,A61K,A61P,C07K

Abstract:
1. A method for increasing the size and/or number of sebaceous glands in a subject in need thereof, the method comprising contacting said subject with an isolated monoclonal anti-EDAR agonist antibody or antigen-binding portion or fragment thereof that binds human and/or mouse EDAR and wherein the isolated monoclonal anti-EDAR antibody or antigen binding portion or fragment thereof comprises: a) a heavy chain variable region comprising the complementary determining region (CDR) amino acid sequences: SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9; or SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15; or SEQ ID NO: 19, SEQ ID NO: 20, and SEQ ID NO: 21; or SEQ ID NO: 25, SEQ ID NO: 26, and SEQ ID NO: 27; and b) a light chain variable region comprising the complementary determining region (CDR) amino acid sequences of SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6; or SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; or SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18; or SEQ ID NO: 22, SEQ ID NO: 23, and SEQ ID NO: 24; or SEQ ID NO: 28, SEQ ID NO: 29, and SEQ ID NO: 30.