Patent ID: 7919627
Filing Date: 2011-04-05
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (I): wherein R (a) hydrogen; and (b) NH or one of R (a) C(O)R (b) C(O)OR (c)  wherein A and B are each independently hydrogen, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted cyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alicyclic group, or a substituted or unsubstituted heteroaryl group or A and B taken together with the carbon to which they are attached form a cyclic moiety selected from: aryl, substituted aryl, heterocyclic, substituted heterocyclic, alicyclic, or substituted alicyclic alternatively, R said process comprising: (1) reacting pyrazole with (6-chloro-pyridin-3-yl)-methanol in the presence of: (a) an acid catalyst; (b) a neat organic acid; or (c) a transition metal catalyst and base; to form a compound of formula III (2) halogenating the compound of formula III with a chlorinating reagent to provide a compound of formula (VI): (3) reacting a compound of the formula R