Patent ID: 8921380
Filing Date: 2014-12-30
Classification: A61P,C07D

Abstract:
1. A compound of the formula [I-I]: wherein R R R E is a group of the formula: —C(═O)— or —SO R′ is a group of the following formula [i], [ii] or [iii]: Ring A is (a) a C Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom, a group of the formula: —SO—, a group of the formula: —SO R or (h) hydroxyl group, R a and R b are the same or different and each hydrogen atom, hydroxyl group, cyano group, an alkyl group, a cyanoalkyl group; a trihalogenoalkyl group, a hydroxyalkyl group, an alkyloxyalkyl group, a cycloalkyl group, an alkylsulfonyl group or an aminoalkyl group (the amino moiety of said group being optionally substituted by one or two alkyl group(s)), or both R a and R b combine each other at their termini to form a saturated or unsaturated nitrogen-containing heterocyclic group optionally containing a heteroatom(s), other than the nitrogen atom, selected from sulfur atom and oxygen atom, R one of R