Patent ID: 6225473
Filing Date: 2001-05-01
Classification: A61P,C07D

Abstract:
A process for the preparation of (-)cis-3-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)piperidine (II) ##STR12##comprisesa.sub.1) converting 1-methylpiperidin-4-one (III) ##STR13##into the hydrobromide according to known processes, ora.sub.2) converting 1-methylpiperidin-4-one (III) directly into the hydrobromide, prior to the subsequent bromination, by introduction of 1-methylpiperidin-4-one into an HBr glacial acetic acid solution, andb) reacting 1-methylpiperidin-4-one hydrobromide in a suitable solvent in the temperature range from 0.degree. C.-30.degree. C. with bromine to give 3(R,S)-bromo-1-methyl-4-oxopiperidine hydrobromide (IV) ##STR14##c) reacting this intermediate (IV) directly by addition of 0.8-1 equivalent of 1,3,5-trimethoxybenzene (V) ##STR15##to the reaction solution at 0.degree.-30.degree. C. to give 3(R,S)-bromo-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridin e hydrobromide (VI) ##STR16##and, if appropriate, additionally adding acetic anhydride to remove any water of reaction formedd.sub.1) first isolating the compound (VI) as a solid by stirring the reaction solution into a suitable organic solvent, and subsequently reacting the resulting product with water and by stirring at 50.degree.-100.degree. C. to give 3(R,S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyrid ine (VII) ##STR17##ord.sub.2) treating the reaction mixture containing the compound (VI) directly with water and reacting by stirring at 50.degree.-100.degree. C. to give 3(R,S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyrid ine (VII), andd.sub.3) cooling the reaction mixtures obtained according to d.sub.1) or d.sub.2), if appropriate diluting further with water and adjusting to pH >12 at 0.degree.-30.degree. C. by addition of aqueous alkali, 3(R,S)-hydroxy-1-methyl4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridi ne (VII) precipitating, filtering off the resulting crude product with suction and if appropriate, for purification, taking it up again in aqueous hydrochloric acid, filtering and optionally extracting with a water-immiscible solvent, and then adjusting the aqueous phase to pH >12 by addition of aqueous alkali, 3(R,S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyrid ine (VII) precipitating, extracting the precipitated product, if appropriate for further purification, by stirring with one or more suitable organic solvents or alternatively mixtures of these solvents, ande.sub.1) catalytically hydrogenating the resulting product (VII) in a suitable solvent or mixtures of these solvents using a suitable catalyst to give the racemic 3,4-cis alcohol (VIII) ##STR18##where the 3,4-trans alcohol, which possibly results in small amounts during the reduction, can be removed by crystallization from suitable solvents, ore.sub.2) for the hydrogenation, employing easily accessible esters (IXa) or carbonates (IXb) of the compound (VII) ##STR19##in which R is (C.sub.1 -C.sub.16)-alkyl, (C.sub.6 -C.sub.14)-aryl-(C.sub.1 -C.sub.16)-alkyl or (C.sub.6 -C.sub.14)-aryl and in the formula (IXa) is further carboxy-(C.sub.2 -C.sub.6)-alkyl,compounds (Xa) and (Xb) being obtained, from which the compound (VIII) can be liberated by known procedures,f.sub.1) obtaining the enantiomerically pure cis alcohol (II) from the compound (VIII) by a known process by resolution using suitable chiral auxiliary reagents, orf.sub.2) carrying out the resolution using the compounds (Xa) or (Xb) ##STR20##where R is (C.sub.1 -C.sub.16)-alkyl, (C.sub.6 -C.sub.14)-aryl-(C.sub.1 -C.sub.16)-alkyl or (C.sub.6 -C.sub.14)-aryl and in the formula (Xa) is further carboxy-(C.sub.2 -C.sub.6)-alkyl,and then converting these into the compound (II) by known processes,it also being possible to exchange the sequence of the reaction steps e) and f), i.e. also to carry out the resolution as early as at the stage of the allyl alcohol (VII) or of the compounds (IXa) and (IXb) obtained therefrom.