Patent ID: 6020342
Filing Date: 2000-02-01
Classification: A61P,C07D

Abstract:
Fused imidazo[1,2-a]pyridines represented by the following general formula (I): ##STR16## wherein ring A represents an aromatic ring selected from benzene, thiophene, furan or pyrrole ring; any one of Z.sup.1, Z.sup.2, or Z.sup.3 represents a sulfur atom with the other two Z groups being carbon; R.sup.1 is a hydroxyl group, halogen atom, lower alkyl group which may be halogenated, lower alkoxy group or acyloxy group;k represents 0, 1, 2 or 3;R.sup.2 and R.sup.3 may be the same or different and each represent a hydrogen atom, alkenyl group, acyl group, alkoxycarbonyl group or lower alkyl group which may have substituent(s) selected from the group consisting of 1) halogen atom, 2) hydroxyl group, 3) lower alkoxy group, 4) lower alkylthio group, 5) alkylsulfinyl group, 6) alkoxycarbonyl group, 7) carbamoyl group, 8) alkylamino group and 9) aryl group, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, may form a 5- or 6-membered monocyclic heterocyclic ring, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, may form an alkylideneamino group or arylalkylideneamino group; R.sup.4 and R.sup.5 each independently represent a halogen atom, cyano group, hydroxyl group, carboxyl group, alkoxycarbonyl group, acyl group, alkylamino group, aryl group, acyloxy group, carbamoyloxy group, lower alkyl group which may have substituent(s) selected from the group consisting of 1) hydroxyl group, 2) lower alkoxy group, 3) aryl group and 4) aryloxy group, lower alkoxy group which may have substituent(s) selected from the group consisting of 1) hydroxyl group, 2) lower alkoxy group, 3) lower alkoxycarbonyl group and 4) aryl group, or lower alkylthio group which may be substituted with an aryl group;R.sup.6, which may be present or absent, is selected from the group consisting of a halogen atom, lower alkyl group which may be halogenated, or lower alkoxy group; m represents 0, 1 or 2; n represents 0, 1 or 2; the dotted line, together with the solid line, represents a single or double bond, provided that plural R.sup.4 s may be attached to the same carbon atom, or a pharmaceutically acceptable salt or solvate thereof.