Patent ID: 6440427
Filing Date: 2002-08-27
Classification: A61F,A61K,A61L

Abstract:
A tissue treatment composition consisting essentially of the following components:(i) factor XIII; (ii) fibrinogen; (iii) thrombin and optionally bivalent calcium; (iv) at least one component selected from the group consisting of a viscosity enhancing polysaccharide and a viscosity enhancing proteoglycan which is capable of forming a viscous aqueous solution; and (v) optionally at least one member selected from the group consisting of fibronectin, a plasmin inhibitor, a plasminogen activator inhibitor, and plasminogen; with the proviso that said fibrinogen containing component is separate from said thrombin containing component until said components are mixed together at the time of treatment; and with the proviso that said composition, upon said mixing of the components, has an initial viscosity in the range of about 500 to 1,000,000 cP.