Patent ID: 6509344
Filing Date: 2003-01-21
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinR1 is hydrogen, formyl, phenyl, phenyl substituted with C1-C6 alkoxy, phenyl substituted with C1-C6 alkyl, or â€”(CH2)mZ, wherein m is 1-6 and Z is selected from the group consisting of hydrogen, hydroxy, carboxy, formyl, C1-C6 alkyl, carbo-(C1-C6 alkoxy), C2-C6 alkenyl, phenyl, C1-C6 alkylamino, and C1-C6 hydroxyalkylamino; R2, R2â€² and R4 are independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, phenoxy, and benzyloxy, or R2 and R2â€², taken together, form â€”OCH2Oâ€”; R3 and R3â€² are independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, phenoxy, and benzyloxy, or R3 and R3â€², taken together, form â€”OCH2Oâ€”; n=1 or 0, and bond a is a single bond when n=1, and bond a is a double bond when n=0; provided that, when R2 and R2â€² are CH3O, R3 and R3â€², taken together, form â€”OCH2Oâ€”, R4 is hydrogen, and n=0, R1 is not â€”CH2CH3 or â€”CH2Ph; and further provided that, when R1 is methyl, R3 and R3â€² are independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, phenoxy, and benzyloxy.