Patent ID: 8461166
Filing Date: 2013-06-11
Classification: A61K,A61P,C07B,C07D

Abstract:
1. A radiolabeled compound having the general Formula I*: and comprising a radiolabeled polyalkylene glycol or a non-radiolabeled polyalkylene glycol moiety being covalently attached at position 7 of the compound having said Formula I, wherein: Q1 is X—W(═Y)—Z and Q2 is absent, X is —NR W is selected from the group consisting of a non-radioactive carbon and a radioactive carbon; Y is selected from the group consisting of oxygen and sulfur; Z is selected from the group consisting of —R R A, B, C and D are each independently selected from the group consisting of hydrogen, a first non-radioactive derivatizing group and a first radioactive derivatizing group selected from a radioactive bromine, a radioactive iodine and a radioactive fluorine; R R R R R and wherein said polyalkylene glycol moiety has a general Formula II*: wherein: m is an integer from 1 to 6; n is an integer from 2 to 10; U is O, S or NR′″; V is selected from the group consisting of a radioactive third derivatizing group and a non-radioactive third derivatizing group selected from the group consisting of a radioactive atom, hydroxyl, thiol, amine, alkyl, cycloalkyl, halogen, haloalkyl, alkoxy, thioalkoxy, thiophenyl, alkenyl, alkynyl, amide, carboxylate, thiocarboxylate, sulfinyl, sulfonyl, carbamyl, thiocarbamyl, nitro and cyano; and R′, R″ and R′″ are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl, the compound comprising at least one radioactive atom.