Patent ID: 6319513
Filing Date: 2001-11-20
Classification: A61K,A61P

Abstract:
A per oral or oral mucoretentive, aqueous liquid, pharmaceutical composition comprising:(a) from about 2% to about 50%, by weight of the composition, of colloidal particles of titanium dioxide; and(b) a safe and effective amount of a pharmaceutical active selected from the group consisting of gastrointestinal agents, analgesics, decongestants, expectorants, antitussives, antihistamines, bronchodilators, topical anesthetics, sensory agents, oral care agents, miscellaneous respiratory agents, and mixtures thereof;wherein the composition has a sedimentation volume ratio of greater than about 0.90 when measured after about 48 hours, a triggered viscosity ratio of at least about 1.2; wherein the gastrointestinal agent is selected from the group consisting of anticholinergics, H2-receptor antagonists, laxatives, gastroprotectants, gastrokinetic and prokinetic agents, proton pump inhibitors, antidiarrheals, agents effective for the treatment of H. pylori, polyanionic agents, plant extracts effective for the treatment of gastrointestinal disorders, and mixtures thereof.