Patent ID: 6548502
Filing Date: 2003-04-15
Classification: A61K,A61P

Abstract:
A method of treating or preventing a novelty-seeking disorder in a subject in need thereof, said novelty-seeking disorder selected from pathological gambling, attention deficit disorder with hyperactivity disorder, and sex addition1 comprising administering to the subject:an amount of a compound having the formula: wherein Ar is phenyl, naphthyl, benzoxazolonyl, indolyl, indolonyl, benzimidazolyl, quinolyl, furyl, benzofuryl, thienyl, benzothienyl, oxazolyl, benzoxazolyl; Ar1 is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzisoxazolyl, or benzisothiazolyl; A is O, S, SO, SO2, C&boxH;O, CHOH, or â€”(CR3R4)â€”; n is 0, 1 or 2; each of Ar and Ar1 may be independently and optionally substituted with one to four substituents independently selected from the groups consisting of fluoro, chloro, bromo, iodo, cyano, nitro, thiocyano, â€”SR, â€”SOR, â€”SO2R, â€”NHSO2R, â€”(C1-C6)alkoxy, â€”NR1R2, â€”NRCOR1, â€”CONR1R2, Ph, â€”COR, COOR, â€”(C1-C6)alkyl, â€”(C1-C6)alkyl substituted with one to six halogens, â€”(C3-C6)cycloalkyl, and trifluoromethoxy; each and every R, R1, and R2 is independently selected from the group consisting of hydrogen, â€”(C1-C6)alkyl, â€”(C1-C6)alkyl substituted with one to thirteen halogens selected from fluorine, chlorine, bromine and iodine, phenyl, benzyl, â€”(C2-C6)alkenyl, â€”(C3-C6)cycloalkyl, and , â€”(C1-C6)alkoxy; each and every R3 and R4 is independently selected from a group consisting of hydrogen, methyl, ethyl, n-propyl, and i-propyl; diastereomeric and optical isomers thereof; and pharmaceutically acceptable salts thereof.