Patent ID: 8481527
Filing Date: 2013-07-09
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein R R R R trifluoromethyl; C 1 -C 4 alkyl; C 1 -C 4 alkoxy; trifluoromethoxy; C 1 -C 4 alkoxycarbonyl; —C(═O)—NH 2 ; and hydroxy group; Z is selected from (1) single bond; (2) oxygen atom; (3) CH Q is selected from optionally substituted with —(CH 2 ) m —OH group or —(CH 2 ) n —X—P group; optionally substituted with one or more C 1 -C 4 alkyl group, one or more halogen atom, —(CH 2 ) m —OH group, —(CH 2 ) m —NH 2 group, —(CH 2 ) m —CO—NH 2 group, trifluoromethyl group, oxo group, —(CH 2 ) m —CN group, —NH—CO—(C 1 -C 4 alkyl) group, —NH—SO 2 —(C 1 -C 4 alkyl) group, —(CH 2 ) m —COOR c group, —CO—NR c R d group, —(C 1 -C 4 alkoxy) group, —NH—CO—(CH 2 ) m —CF 3 group, or —NH—SO 2 —CH 2 —CF 3 group; group; optionally substituted with an oxo group, —SO 2 —(C 1 -C 4 alkyl) group, C 1 -C 4 alkyl group, —CO—(C 1 -C 4 alkyl) group, —(CH 2 ) m —O—(CH 2 ) m —OH group, —(CH 2 ) m —OH group, —SO 2 —NR c R d group, or —CO—NR c R d group; group; group; group; optionally substituted with —(CH 2 ) m —OH group, group; group; and, group; Y is selected from (1) —(CH n is an integer from 0 to 6; m is an integer from 0 to 3; X is selected from (1) single bond; (2) oxygen atom; (3) —CO—NR P is selected from (1) phenyl group, optionally substituted with one or more halogen atom, hydroxy, cyano, amino or C R R R R R A is selected from (1) a C B is selected from a 4-7 membered ring containing 1-3 heteroatom selected from O, S, SO W W