Patent ID: 6531479
Filing Date: 2003-03-11
Classification: A61P,C07D

Abstract:
A compound of general formula I: whereinone of X1 and X2 is S, and the other of X1 and X2 is N; Z is NH, NHCO, NHSO2, NHCH2, CH2, CH2CH2, or CH&boxH;CH; R1, R2, and R3 are independently H, alkyl, aryl, aralkyl, heterocycle, halogen, NO2, CN, OH, alkoxy, aryloxy, NH2, NHâ€”Râ€², Nâ€”(Râ€²)(Râ€³), NHâ€”CORâ€², NH-aryl, N-(aryl)2, COOH, COOâ€”Râ€², COO-aryl, CONH2, CONHâ€”Râ€², CONâ€”(Râ€²)(Râ€³), CONH-aryl, CON-(aryl)2, SO3H, SO2NH2, CF3, COâ€”Râ€², or CO-aryl, wherein alkyl, aryl, aralkyl, heterocycle and NH-aryl groups may be further substituted with one or more groups selected from halogen, NO2, CN, OH, O-methyl, NH2, COOH, CONH2 and CF3; at least one of the groups R1 and R2 being other than H when either X1 or X2 is S; R4, R5, R6, R7, and R8 are independently from each other H, substituted or unsubstituted lower alkyl, halogen, amino, carbamoyl, sulfamyl, NO2, CN, OH, substituted or unsubstituted alkoxy, NH2, NHâ€”Râ€², alkyl-aryl, alkyl-heteroaryl, NH(C&boxH;NH)NH2, N(Râ€²)3+, Nâ€”(Râ€²)(Râ€³), COOH, COOâ€”Râ€², CONH2, CONHâ€”Râ€², CONâ€”(Râ€²) (Râ€³), SO3H, SO2NH2, CF3 or (CH2)nO(CH2)mNRâ€²Râ€³, (CH2)nCO2(CH2)mORâ€²â€³ wherein n is 0, 1, 2 or 3 and m is 1, 2 or 3; wherein Râ€², Râ€³ and Râ€²â€³ are each independently alkyl groups that may be the same or different;and pharmaceutically acceptable salts thereof.