Patent ID: 8574551
Filing Date: 2013-11-05
Classification: A61K,A61P

Abstract:
1. A method of inhibiting or reducing nephrotoxicity associated with an iodinated contrast agent, the method comprising: administering to a subject in need thereof a first pharmaceutical composition comprising an anionically substituted cyclodextrin of the formula: where R is selected from the group consisting of straight chained or branched C Y is an anionic group selected from COO, SO Me is a pharmaceutically acceptable cation; and n is a whole number greater than 1, and administering to the subject a second pharmaceutical composition comprising an iodinated contrast agent selected from iohexyl, ioversol, diatrizoate meglumine and ioxaglate; wherein the molar ratio of agent: cyclodextrin is from 2:1 to 50:1.