Patent ID: 6589951
Filing Date: 2003-07-08
Classification: A61P,C07D

Abstract:
A compound of formula I wherein G is methylene, ethylene, imino, CONH or a bond;Cy is phenyl or a 5- or 6-membered heterocycle of the group consisting of pyrrole, imidazole, pyrazole, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, pyridine, pyrazine, pyrimidine, pyridazine, piperazine, piperidine, and triazine, the Cy residue being optionally substituted by one or more substituent(s) selected from the group consisting of keto, nitro, carboxy, fluorine, chlorine, bromine, or iodine; R is H, phenyl or a (C1-4)alkyl group optionally substituted by phenyl; R1 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; R2 is aryl, aryl-(C1-10)-alkyl, (C4-7)cycloalkyl or (C4-7)heterocycle wherein the heteroatom is an oxygen atom; and the derivatives of formula (I) in which one and/or the other of the nitrogens of the phthalazine central nucleus as well as the nitrogens on the substituent Cy may be an Nâ†’O oxide, or the pharmaceutically acceptable salts thereof; with the proviso that when R is H, R2 is not aryl-methyl.