Patent ID: 7375238
Filing Date: 2008-05-20
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a N-(N′-substituted glycyl)-2-cyanopyrrolidine comprising at least (a) reacting, in the presence of dimethylformamide, a compound of formula (V)  wherein, independently of each other, X1 and X3 are halogen; X2 is halogen, OH, O—C(═O)—CH  with L-prolinamide, followed by (b) reacting the resultant compound without isolation with a dehydration agent selected from (haloalkylene)dialkylammonium halide followed by (c) reacting, in the presence of a base, the resultant compound without isolation with an appropriate amine and (d) recovering the resultant compound in free form or in acid addition salt form.