Patent ID: 8524368
Filing Date: 2013-09-03
Classification: A61K,C08L,Y10T

Abstract:
1. A multilayered interpolyelectrolyte complex comprising a first layer comprising a first interpolyelectrolyte complex and a second layer comprising a second interpolyelectrolyte complex, wherein each of the first and second interpolyelectrolyte complexes, independently from one another, comprise: a. a dynamic charge state cationic polymer having a polymeric backbone formed from monomeric units, and one or more removable functional groups attached to the polymeric backbone through one or more labile linkages, wherein the one or more removable functional groups are selected from the group consisting of an ester, anhydride, orthoester, phosphorester, acetal, amide, amino, alkylamino, cyano, carbamoyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic, aryl, and heteroaryl group; and b. one or more anions complexed to said cationic polymer; wherein the overall positive charge of the cationic polymer decreases when one or more of the removable functional groups is removed from the polymeric backbone, thereby causing said one or more anions to disassociate from the cationic polymer, wherein the cationic polymer and one or more anions in the first interpolyelectrolyte complex can be the same or different from the cationic polymer and one or more anions in the second interpolyelectrolyte complex.