Patent ID: 6680365
Filing Date: 2004-01-20
Classification: C07K

Abstract:
A method of making a mixture containing a solvent and a block copolypeptide comprising:(a) reacting a first amino acid N-carboxyanhydride (NCA) monomer with an initiator complex in a suitable solvent, said complex comprising a low valent transition metal and a Lewis Base donor ligand, for a time and under conditions effective to exhaust the first monomer and to generate a mixture containing a polyamino acid chain bearing an amido-containing metallacycle end group and the solvent; and (b) reacting a second amino acid NCA monomer with the polyamino acid chain of step (a), wherein the second monomer is different from the first monomer, for a time and under conditions effective to exhaust the second monomer and to generate a mixture containing a block copolypeptide and the solvent.