Patent ID: 6492335
Filing Date: 2002-12-10
Classification: A61K,A61P,C07D,C07H,C07K

Abstract:
Compounds of the general formula (I)Aâ€”Cpâ€”Bâ€ƒâ€ƒ(I) in which Cp represents a group of the formulae in which R1, R2, R3 and R4 independently of one another may represent hydrogen, alkyl having up to 3 carbon atoms, halogen, amino, hydroxyl or nitro or R2 and R3 together represent a group of the formula m may have the values 1 or 2 and R5 represents â€”CH2â€”Oâ€”*, â€”CH2â€”NH*, or represents in which R6 represents arylmethyl or hetarylmethyl, R1-R5 not all being hydrogen in which R7 and R8 are as defined for R2 and R3 and may be identical or different to these, in which R9 represents hydrogen or â€”CH2â€”N(CH3)2 and R10 represents hydrogen or ethyl, or in which R11 and R12 are as defined for R2 and R3 and may be identical or different to these, or in which R13 and R14 are as defined for R2 and R3 and may be identical or different to these, where Cp is attached to A on the positions labelled # and attached to B on the positions labelled *, A represents a radical of the formula where 1&lE;(n+o+p)&lE;3, B represents hydrogen or a radical of the formula where 0&lE;(q+r+s)&lE;3, in which M1 and M2 independently of one another each represent a bridge grouping whose main chain includes up to 21 atoms in linear order, L1, L2, L3, L4, L5 and L6 independently of one another each represent linker groupings, Sp1, Sp2, Sp3, Sp4, Sp5 and Sp6 independently of one another each represent arylene having up to 10 carbon atoms or represent alkylene having up to 8 carbon atoms which are in each case optionally substituted, and K1, K2, K3, K4, K5 and K6 independently of one another each represent a radical of the formula (II) in which C represents methyl, hydroxymethyl, alkoxymethyl having up to 6 carbon atoms, acyloxymethyl having up to 6 carbon atoms or a radical of the formula â€”CH2â€”D in which D represents a radical of the formula (II), R15, R16 and R17 independently of one another each represent hydrogen, hydroxyl, optionally hydroxyl-substituted alkoxy having up to 6 carbon atoms, amino which is optionally substituted by alkyl or acyl having up to 6 carbon atoms, halogen, sulphate or a group of the formulae in which R18 and R19 independently of one another each represent hydroxyl or alkoxy having up to 6 carbon atoms or represent amino which is optionally substituted by alkyl having up to 6 carbon atoms, and u and v independently of one another may each have the values 0, 1, 2, 3 or 4, in particular the values 1, 2, 3 or 4, or R15, R16 and R17 independently of one another each represent a radical of the formula (II) or two of the radicals R15, R16, R17 together represent an epoxy group, or compounds of the formula; in which R1, R2, R3, R4, and A are as defined above; and R5 represents H, â€”CH2CH3, or represents â€”CH2â€”N(CH2CH3)R6, in which R6 represents arylmethyl or hetarylmethyl, and their isomers, isomer mixtures and salts.