Patent ID: 9035047
Filing Date: 2015-05-19
Classification: A61K,A61P,C07D

Abstract:
1. A compound, or a therapeutically acceptable salt thereof, wherein the compound is selected from the group consisting of: 7-(2-methylphenyl)-1-(2-morpholin-4-ylethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-methylphenyl)-1-(2-morpholin-4-ylethyl)-3-(3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid; 7-(1,1′-biphenyl-2-yl)-1-(2-morpholin-4-ylethyl)-3-(3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-methylphenyl)-1-(3-morpholin-4-ylpropyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-methylphenyl)-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-methylphenyl)-1-(2-(4-methylpiperazin-1-yl)ethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 1-(2-morpholin-4-ylethyl)-7-(2-morpholin-4-ylphenyl)-3-(3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-methylphenyl)-1-(2-morpholin-4-yl-2-oxoethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-3-(3-1-naphthyloxy)propyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carboxylic acid; 7-(4,6-dimethylpyrimidin-5-yl)-1-(2-morpholin-4-yl-2-oxoethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 1-(2-(4-methylpiperazin-1-yl)ethyl)-3-(3-(1-naphthyloxy)propyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carboxylic acid; 1-(2-morpholin-4-ylethyl)-3-(3-(1-naphthyloxy)propyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carboxylic acid; 1-(2-morpholin-4-yl-2-oxoethyl)-3-(3-(1-naphthyloxy)propyl)-7-(1,3,5-trimethy-1H-pyrazol-4-yl)-1H-indole-2-carboxylic acid; 7-(2-ethyl-4-methylpyridin-3-yl)-1-(2-morpholin-4-yl-2-oxoethyl)-3-(3-1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7(2-ethyl-4-methylpyridin-3-yl)-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-ethyl-4-methylpyridin-3-yl)-1-(2-morpholin-4-ylethyl 3-(3--(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; 7-(2-ethyl-4-methylpyridin-3-yl)-1-(2-(4-methylpiperazin-1-yl)ethyl)-3-(3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylie acid; 7-(2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl)-1-(2-morpholin-4-yl-2-oxoethyl)-3-(1-naphthyloxy)propyl)-1H-indole-2-carboxylic acid; and 7-(2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl)-3-(3-(1-naphthyloxyl)propyl)-1-(2-oxo-2-piperazin-1-ylethyl)-1H-indole-2-carboxylic acid.