Patent ID: 6046217
Filing Date: 2000-04-04
Classification: C07D

Abstract:
A compound of formula I ##STR65## or a pharmaceutically acceptable salt thereof, wherein: X is selected from the group consisting of:(a) O,(b) S and(c) a bond,n is 0 or 1,R.sup.1 is selected from the group consisting of.(a) CH.sub.3,(b) NH.sub.2 and(c) NHC(O)CF.sub.3,R.sup.2 is selected from the group consisting of:(a) halo,(b) C.sub.1-6 alkoxy,(c) C.sub.1-6 alkylthio,(d) CN,(e) C.sub.1-6 alkyl,(f) C.sub.1-6 fluoroalkyl,(g) N.sub.3,(h) --CO.sub.2 R.sup.10,(i) hydroxy,(j) --C(R.sup.11)(R.sup.12)--OH,(k) --C.sub.1-6 alkyl-CO.sub.2 -R.sup.13,(1) C.sub.1-6 fluoroalkoxy,(m) NO.sub.2,(n) NR.sup.14 R.sup.15 and(o) NHCOR.sup.16, andR.sup.3 to R.sup.16 are independently selected from the group consisting of:(a) hydrogen and(b) C.sub.1-6 alkyl,or R.sup.3 and R.sup.7, or R.sup.7 and R.sup.8 together with the atoms to which they are attached form a carbocyclic ring of 3, 4, 5, 6 or 7 atoms, or R.sup.3 and R.sup.5 are joined to form a bond.