Patent ID: 6184225
Filing Date: 2001-02-06
Classification: A61P,C07D

Abstract:
A compound of the formula I: ##STR26##wherein:Z represents --O--, --NH-- or --S--;m is an integer from 1 to 5 with the proviso that where Z is --NH-- m is an integer from 3 to 5;R.sup.1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C.sub.1-3 alkyl C.sub.1-3 alkoxy, C.sub.1-3 alkylthio, or --NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6, which may be the same or different, each represents hydrogen or C.sub.1-3 alkyl);R.sup.2 represents hydrogen, hydroxy, halogeno, methoxy, amino or nitro;R.sup.3 represents hydroxy, halogeno, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkanoyloxy, trifluoromethyl, cyano, amino or nitro;X.sup.1 represents --O--, --S--, --SO--, --SO.sub.2 --, --NR.sup.7 --, --NR.sup.8 CO--, --CONR.sup.9 --, --SO.sub.2 NR.sup.10 -- or --NR.sup.11 SO.sub.2 --, (wherein R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 each represents hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxyC.sub.2-3 alkyl);R.sup.4 is selected from one of the following seven groups:1) hydrogen, C.sub.1-5 hydroxyalkyl, C.sub.1-5 fluoroalkyl, C.sub.1-5 aminoalkyl;2) C.sub.1-5 alkylX.sup.2 COR.sup.12 (wherein X.sup.2 represents --O-- or --NR.sup.13 -- (in which R.sup.13 represents hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxyC.sub.2-3 alkyl) and R.sup.12 represents C.sub.1-3 alkyl, --NR.sup.14 R.sup.15 or --OR.sup.16 (wherein R.sup.14, R.sup.15 and R.sup.16 which may be the same or different each represents hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxyC.sub.2-3 alkyl));3) C.sub.1-5 alkylX.sup.3 R.sup.17 (wherein X.sup.3 represents --O--, --S--, --SO--, --SO.sub.2 --, --OCO--, --NR.sup.18 CO--, --CONR.sup.19 --, --SO.sub.2 NR.sup.20, --NR.sup.21 SO.sub.2 -- or --NR.sup.22 -- (wherein R.sup.18, R.sup.19, R.sup.20, R.sup.21 and R.sup.22 each independently represents hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxyC.sub.2-3 alkyl) and R.sup.17 represents hydrogen, C.sub.1-3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6 membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which C.sub.1-3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and C.sub.1-4 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C.sub.1-4 alkyl, C.sub.1-4 hydroxyalkyl and C.sub.1-4 alkoxy);4) C.sub.1-5 alkylR.sup.23 (wherein R.sup.23 is a 5 or 6 membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C.sub.1-4 alkyl, C.sub.1-4 hydroxyalkyl and C.sub.1-4 alkoxy);5) C.sub.2-5 alkenylR.sup.23 (wherein R.sup.23 is as defined hereinbefore);6) C.sub.2-5 alkynylR.sup.23 (wherein R.sup.23 is as defined hereinbefore); and7) C.sub.1-5 alkylX.sup.4 C.sub.1-5 alkylX.sup.5 R.sup.24 (wherein X.sup.4 and X.sup.5 which may be the same or different are each --O--, --S--, --SO--, --SO.sub.2 --, --NR.sup.25 CO--, --CONR.sup.26 --, --SO.sub.2 NR.sup.27 --, --NR.sup.28 SO.sub.2 -- or --NR.sup.29 -- (wherein R.sup.25, R.sup.26, R.sup.27, R.sup.28 and R.sup.29 each independently represents hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxyC.sub.2-3 alkyl) and R.sup.24 represents hydrogen or C.sub.1-3 alkyl);and salts thereof.