Patent ID: 6492418
Filing Date: 2002-12-10
Classification: A61K,A61P,Y10S

Abstract:
A method for prophylactically treating an allergic disease of the eye, nose, skin, ear or lung in a patient suceptible to the same or treating an allergic disease of the eye, nose, skin, ear or lung in a patient experiencing the same comprising topically administering to the patient a composition comprising a disulfide derivative of the formula wherein X is â€”C(&boxH;O)â€”N(â€”R1)â€”R;R and R1 are independently H; (un)substituted phenyl; (un)substituted benzyl; or C1-C8 alkyl or alkenyl, optionally substituted with or terminated by OH, OR2, NR3R4; C4-C7 cycloalkyl, (un)substituted aryl, or (un)substituted 5-7 membered heterocyclic ring; where optional substituents are selected from the group consisting of C1-C6 alkyl or alkoxy; halogen; OH; CN; CF3; NO2; and CO2R2; R2 is C1-C3 alkyl; and R3 and R4 are independently H; benzyl; C1-C8 alkyl or alkenyl; C4-C7 cycloalkyl; (un)substituted aryl; or (un)substituted 5-7 membered heterocyclic ring; wherein optional substituents are selected from the group consisting of C1-C6 alkyl or alkoxy; halogen; OH; CN; CF3; NO2; and CO2R2.