Patent ID: 7718579
Filing Date: 2010-05-18
Classification: B01J,B82Y

Abstract:
1. A method for electrochemical deblocking of an acid-labile protecting group, comprising applying a voltage or a current to at least one anode of an array of electrodes electrically connected a counter cathode separate from the array of electrodes, wherein the array of electrodes is covered by a deblocking solution, wherein the deblocking solution comprises an organic solvent and: (a) a salt, whereby the salt provides conductivity to the deblocking solution; and (b) a hydrazine derivative, wherein the hydrazine derivative comprises at least one hydrazine group having at least one hydrogen atom attached to the at least one hydrazine group, wherein the hydrazine derivative provides an acidic electrochemically-generated reagent and substantially isolates the acidic reagent to a non-overlapping area surrounding the at least one electrode, whereby the electrochemical deblocking occurs when the acidic reagent removes at least one acid-labile protecting group of a chemical species attached to a reactive layer bound to the at least one electrode.