Patent ID: 6054464
Filing Date: 2000-04-25
Classification: A61P,C07D,C07F

Abstract:
A method of treatment or prophylaxis of Parkinson's disease, Huntington's disease, Tourette's syndrome, Amyotropic Lateral Sclerosis or neurodegenerative disorders in which there is dysfunction of the cholinergic system, which comprises administering a therapeutically effective amount of a compound of formula ##STR6## wherein: A is ##STR7## X is O or S; Y is O or S;G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen;E is N or C--R.sub.4 ;R.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen or fluoro;R.sub.3 is hydrogen, halogen, C.sub.1 to C.sub.3 alkyl, --OR.sub.5, --CN, --CONH.sub.2, --CO.sub.2 R.sub.5, --NR.sub.5 R.sub.6 or phenyl optionally substituted with one to three of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.2, --CH, or --OCH.sub.3 ;R.sub.4 is hydrogen, halogen, C.sub.1 to C.sub.3 alkyl, --OR.sub.5, --CN, --CONH.sub.2, --CO.sub.2 R.sub.5, --NR.sub.5 R.sub.6 or phenyl optionally substituted with one to three of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.2, --CN, or --OCH.sub.3 ;or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.2, --CN, or --OCH.sub.3 ;R.sub.5 and R.sub.6 are independently hydrogen or C.sub.1 to C.sub.3 alkyl;or an enantiomer thereof, or a pharmaceutically acceptable salt thereof.