Patent ID: 7307154
Filing Date: 2007-12-11
Classification: A61K,A61P,C07K

Abstract:
1. A method for selectively destroying a cell expressing the polypeptide of SEQ ID NO:2 comprising contacting said cell with an amount of immunoconjugate that can destroy said cell, wherein said immunoconjugate comprises an isolated antibody, or fragment thereof, conjugated to a cytotoxic agent, and wherein said isolated antibody, or fragment thereof, specifically binds to a polypeptide sequence selected from the group consisting of: (a) amino acid 28 to amino acid 46 of SEQ ID NO: 2; (b) amino acid 77 to amino acid 91 of SEQ ID NO: 2; (c) amino acid 188 to amino acid 210 of SEQ ID NO: 2; and (d) amino acid 263 to amino acid 274 of SEQ ID NO: 2.