Patent ID: 8399476
Filing Date: 2013-03-19
Classification: A61P,C07D

Abstract:
1. A pharmaceutical composition comprising at least one compound of formula Ia, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, in which R is chosen from halogen, (C wherein the aryl residue can be substituted by one or more identical or different substituents chosen from halogen, (C or two adjacent R groups form, together with the carbon atoms which carry them, a 4-membered to 7-membered, partially unsaturated or aromatic heterocyclic ring which can be substituted by one or more identical or different substituents R13 and which can contain one or two ring members chosen from ═N—, —N(R4)-, —C(═O)—, —O—, —S—, —S(O)— and —S(O) R1 is chosen from hydrogen and (C or R and R1 form together a (C R2 is chosen from hydrogen, hydroxy and (C R3 is chosen from Br, cyano, nitro, —C(═O)—NR9R10, amino, —N(R11)-C(═O)—R12, COOH, (C R4 is each time independently chosen from hydrogen and (C R5 is chosen from hydrogen, (C R6 is chosen from hydrogen, cyano, hydroxy, (C or R5 and R6 form, together with the —N═C—NH— group which carries them, a 4-membered to 7-membered, partially unsaturated or aromatic heterocyclic ring which can be substituted by one or more identical or different substituents R14 and which, in addition to the nitrogen atoms being part of the —N═C—NH— group, can contain one or two further ring members chosen from ═N—, —N(R4)-, —C(═O)—, —O—, —S—, —S(O)— and —S(O) R7 and R8 are independently chosen from hydrogen and (C or R7 and R8 form, together with the nitrogen atom which carries them, a 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocyclic ring; R9 and R10 are independently chosen from hydrogen and (C or R9 and R10 form, together with the nitrogen atom which carries them, a 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocyclic ring; R11 is chosen from hydrogen and (C R12 is chosen from hydrogen and (C or R11 and R12 form, together with the carbonylamino group which carries them, a 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocyclic ring which can be substituted by one or more identical or different substituents R15 and which, in addition to the carbonylamino group connecting R11 and R12, can contain one or two further ring members chosen from ═N—, —N(R4)-, —C(═O)—, —O—, —S—, —S(O)— and —S(O) R13, R14 and R15 are independently chosen from halogen, (C n is chosen from 0, 1, 2, 3, 4 and 5; provided that compounds are excluded in which R1, R2 and R4 are hydrogen, n is 1, R is cyano and R3 is cyano, (C provided that compounds are excluded in which R1 is hydrogen or methyl, R2 and R4 are hydrogen, n is 1, R3 is COOH or (C provided that compounds are excluded in which R1, R2 and R4 are hydrogen and n is 0, and provided that compounds are excluded in which R1, R2 and R4 are hydrogen, R3 is Br, n is 1, and R is Br, NO