Patent ID: 7460961
Filing Date: 2008-12-02
Classification: C07K,G01N,G16B

Abstract:
1. A method for identifying an agent that interacts with N-terminal domain of TNFR- 1 associated death domain protein (N-TRADD), the method comprising: providing a solution comprising N-TRADD; displaying a three-dimensional model of an active site of N-TRADD, wherein the active site of N-TRADD comprises an N-terminal domain of TRADD that interacts with C-TRAF2 and wherein the three dimensional structure of the active site comprises the relative structural coordinates of amino acid residues Y16, L17, F18, V58, L59, K63, I64, H65, D68, Q70, I72, V73, Q74, L75, C78, L118, G121, A122, R124, L125, D149, E150, and L152 according to using the three-dimensional structure of the active site of N-TRADD to design an agent that interacts with the active site of N-TRADD; and obtaining or synthesizing the agent.