Patent ID: 6818654
Filing Date: 2004-11-16
Classification: C07D

Abstract:
A compound having formula (I) in whichone of A1 or R4 is OH or OR11 and the other is C(O)OH or C(O)OR60; R1 and R2 are hydrogen or taken together are &boxH;O; R3 is hydrogen, C(CH3)3, Oâ€”CH2CH&boxH;CH2, or methyl substituted with 2,4-dimethoxyphenyl; R5 is hydrogen, alkyl, halo, OH, CF3, CH2CF3, CF2CF3, or OR11; R6 is hydrogen, halogen, alkyl, CN, NO2, C(O)H, Câ‰¡CH, Câ‰¡C(alkyl), Câ‰¡CCCl3, Câ‰¡CCF3, CH&boxH;CH2, or OR11; R7 is halo, aryl, heteroaryl, heterocyclyl, bicyclic heterocyclyl, NH(R12), or N(R13)(R14), in which the aryl is phenyl which is unsubstituted or substituted with one halo substituent, the heteroaryl is furyl or thienyl, the heterocyclyl is azetidinyl, piperidinyl, or pyrrolidinyl, each of which is unsubstituted or substituted with a substituent selected from the group consisting of alkyl, â€”NH2, â€”OH, and â€”NH(R35), in which R35 is alkyl, and the bicyclic heterocyclyl is six-membered with one or two nitrogen atoms and two non-adjacent carbons attached by a covalent bond or CH2, seven-membered with two nitrogen atoms, eight-membered with 1 nitrogen atom and zero double bonds, eight-membered with two nitrogen atoms, or nine-membered with two nitrogen atoms and zero double bonds, each of which is unsubstituted or substituted with a substituent selected from the group consisting of â€”NH2, â€”NH(R35), and â€”C(O)OR35, in which R35 is alkyl or alkyl substituted with phenyl. R11 is alkyl, C(O)R70, or alkyl substituted with a substituent selected from the group consisting of halo, aryl, â€”NH2, â€”NH(alkyl), and â€”N(alkyl)2; R12, R13, and R14 are independently alkyl or alkyl substituted with a substituent selected from the group consisting of heterocyclyl, â€”NH2, â€”NH(alkyl), and â€”N(alkyl)2; and R60 and R70 are independently alkyl, aryl, or alkyl substituted with a substituent selected from the group consisting of halo, aryl, â€”NH2, â€”NH(alkyl), and â€”N(alkyl)2.