Patent ID: 8318730
Filing Date: 2012-11-27
Classification: A61P,C04B,C07D

Abstract:
1. A method for treating an interleukin-12 overproduction-related disorder, comprising administering to a subject in need thereof an effective amount of a compound of according to formula (V), or pharmaceutically acceptable salts thereof: or a pharmaceutically acceptable salt thereof; wherein, A Ring D is a phenyl which may be further substituted with one or more substituents; U and V are each, N; Z is N; W is O; u is 0, 1, 2, 3, or 4; X is O, S, S(O), S(O) R, for each occurrence, is independently H, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted aryl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, —C(O)R R′ is an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, or absent; L′ is O, S, S(O), S(O) R″ is H, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, N(R Y is (CH(R R R R R R R G is: Hydrazide; Hydrazone; Hydrazine; Hydroxylamine; Oxime; Amide; Ester; Carbonate; Carbamate; Thiocarbamate; —NR k —C(NR)—NR k —; —NR k —C(O)—NR k —; —NR k —C(S)—NR k —; —NR k —S(O) 2 —NR k —; Phosphoryl; an optionally substituted -Cyclyl-; an optionally substituted -Heterocyclyl-; an optionally substituted -Aryl-; an optionally substituted -Heteroaryl-; an optionally substituted -Heteroarylalkyl-; an optionally substituted -Heteroaryl-NR k —; an optionally substituted -Heteroaryl-S—; an optionally substituted -Heteroarylalkyl-O—; —Si(OR k ) 2 —; —B(OR k )— —C(NR)—NR k —; —N(R k )—CRgR g —C(O)—; —C(O)—ON(R k )—; —C(O)—N(R k )O—; —C(S)—ON(R k )—; —C(S)—N(R k )O—; —C(N(R k ))—ON(R k )—; —C(N(R k ))—NR k O—; —OS(O) 2 —N(R k )N(R k )—; —OC(O)—N(R k )N(R k )—; —OC(S)—N(R k )N(R k )—; —OC(N(R k ))—N(R k )N(R k )—; —N(R k )N(R k )S(O) 2 O—; —N(R k )N(R k )C(S)O—; —N(R k )N(R k )C(N(R k ))O—; —OP(O)(R c )O—; —N(R k )P(O)(R c )O—; —OP(O)(R c )N(R k )—; —N(R k )P(O)(R c )N(R k )—; —P(O)(R c )O—; —P(O)(R c )N(R k )—; —N(R k )P(O)(R c )—; —OP(O)(R c )—; —O-alkyl-heterocyclyl-N(R k )—; —N(R k )CHR g C(O)N(R k )CHR g C(O)—; —N(R k )CHR g C(O)—; —N(R k )C(O)CHR g —; —C(O)N(R k )CHR g C(O)—; or absent, each of which is optionally substituted; m, for each occurrence, is independently 1, 2, 3, 4, 5, 6, 7, or 8; n, for each occurrence, is independently 0, 1, 2, 3, 4, 5, 6, or 7; p, for each occurrence, is independently 0, 1, or 2; wherein, in formula (V), when G is absent, then R 3 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, nitro, cyano, halo, OR k , SR k , or NR h R j ; and wherein the disorder is selected from the group consisting of multiple sclerosis, sepsis, myasthenia gravis, autoimmune neuropathies, Guillain-Barré syndrome, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, autoimmune thrombocytopenia, temporal arteritis, anti-phospholipid syndrome, vasculitides, Wegener's granulomatosis, Behcet's disease, psoriasis, psoriatic arthritis, dermatitis herpetiformis, pemphigus vulgaris, vitiligo, Crohn's disease, ulcerative colitis, interstitial pulmonary fibrosis, myelofibrosis, hepatic fibrosis, myocarditis, thyroditis, primary biliary cirrhosis, autoimmune hepatitis, immune-mediated diabetes mellitus, Grave's disease, Hashimoto's thyroiditis, autoimmune oophoritis and orchitis, autoimmune disease of the adrenal gland; rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing spondylitis, Sjogren's syndrome and graft-versus-host disease.