Patent ID: 9029341
Filing Date: 2015-05-12
Classification: A61K,A61P,C12N

Abstract:
1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits expression of the Hepatitis B virus (HBV), comprising a sense strand comprising the nucleotide sequence 5′-uuCCgcagUauGGaUCGGCUsU-3′ (SEQ ID NO:376) and an antisense strand comprising the nucleotide sequence 5′-B GccGAuccAuAcuGcGGAAUsU B-3′ (SEQ ID NO:224), wherein B is an inverted a basic moiety; the bolded nucleotides comprise 2′-O-methyl modifications, the lower case nucleotides comprise 2′-fluoro modifications, and the s is a phosphorothioate linkage.