Patent ID: 8663645
Filing Date: 2014-03-04
Classification: A61K,A61P

Abstract:
1. A method for selecting, in a CTL immune response initiated by a cognate optimized peptide, CTLs having a high avidity for a native peptide, comprising vaccinating a patient, who has been previously vaccinated with said cognate optimized peptide, with a medicinal composition containing the native peptide from which said cognate optimized peptide was derived, wherein the native and its cognate optimized peptides are selected from the group consisting of the following pairs of peptides: TERT572 (SEQ ID No: 1) and TERT572Y1 (SEQ ID No: 2); TERT988 (SEQ ID No: 3) and TERT988Y1 (SEQ ID No: 4); MAGE-A248D9 (SEQ ID No: 5) and MAGE-A248V9 (SEQ ID No: 6); MAGE-A248G9 (SEQ ID No: 7) and MAGE-A248V9 (SEQ ID No: 6); Gp100 154 (SEQ ID No: 8) and Gp100 154Y1 (SEQ ID No: 9); Gp100 154 (SEQ ID No: 8) and Gp100 154M155 (SEQ ID No: 10); FluM58 (SEQ ID No: 11) and FluM58Y1 (SEQ ID No: 12); HIVgag76 (SEQ ID No: 13) and HIVgag76Y1 (SEQ ID No: 14); HBVpo1575 (SEQ ID No: 15) and HBVpo1575Y1 (SEQ ID No: 16); HBVpo1765 (SEQ ID No: 17) and HBVpo1765Y1 (SEQ ID No: 18); Mart-127 (SEQ ID No: 19) and Mart-127Y1 (SEQ ID No: 20); Mart-126 (SEQ ID No: 21) and Mart-126L27 (SEQ ID No: 22); Gp100 177 (SEQ ID No: 23) and Gp100 177Y1 (SEQ ID No: 24); Gp100 178 (SEQ ID No: 25) and Gp100 178Y1 (SEQ ID No: 26); Gp100 570 (SEQ ID No: 27) and Gp100 570Y1 (SEQ ID No: 28); Gp100 209 (SEQ ID No: 29) and Gp100 209Y1 (SEQ ID No: 30); Gp100 209 (SEQ ID No: 29) and Gp100 209M210 (SEQ ID No: 31); Gp100 476 (SEQ ID No: 32) and Gp100 476Y1 (SEQ ID No: 33); Gp100 457 (SEQ ID No: 34) and Gp100 457Y1 (SEQ ID No: 35); HER-2/neu799 (SEQ ID No: 36) and HER-2/neu799Y1 (SEQ ID No: 37); HER-2/neu369 (SEQ ID No: 38) and HER-2/neu369Y1 (SEQ ID No: 39); HER-2/neu789 (SEQ ID No: 40) and HER-2/neu789Y1 (SEQ ID No: 41); HER-2/neu48 (SEQ ID No: 42) and HER-2/neu48Y1 (SEQ ID No: 43); HER-2/neu773 (SEQ ID No: 44) and HER-2/neu773Y1 (SEQ ID No: 45)-; HER-2/neu5 (SEQ ID No: 46) and HER-2/neu5Y1 (SEQ ID No: 47); HER-2/neu851 (SEQ ID No: 48) and HER-2/neu851Y1 (SEQ ID No: 49); HER-2/neu661 (SEQ ID No: 50) and HER-2/neu661Y1 (SEQ ID No: 51); HER-2/neu650 (SEQ ID No: 52) and HER-2/neu650Y1 (SEQ ID No: 53); HER-2/neu466 (SEQ ID No: 54) and HER-2/neu466Y1 (SEQ ID No: 55); HER-2/neu402 (SEQ ID No: 56) and HER-2/neu402Y1 (SEQ ID No: 57); HER-2/neu391 (SEQ ID No: 58) and HER-2/neu391Y1 (SEQ ID No: 59); HER-2/neu971 (SEQ ID No: 60) and HER-2/neu971Y1 (SEQ ID No: 61); HBVpo128 (SEQ ID No: 62) and HBVpo128Y1 (SEQ ID No: 63); HBVpo1594 (SEQ ID No: 64) and HBVpo1594Y1 (SEQ ID No: 65); HBVpo1985 (SEQ ID No: 66) and HBVpo1985Y1 (SEQ ID No: 67); EphA2 61 (SEQ ID No: 68) and EphA2 61Y1 (SEQ ID No: 69); HER2 911 (SEQ ID No: 70) and HER911Y1V10 (SEQ ID No: 71); HER4 911 (SEQ ID No: 72) and HER911Y1V10 (SEQ ID No: 71); HER1 911 (SEQ ID No: 73) and HER911Y1V10 (SEQ ID No: 71); HER2 722 (SEQ ID No: 74) and HER722Y1V9 (SEQ ID No: 75); HER3 722 (SEQ ID No: 76) and HER722Y1V9 (SEQ ID No: 75); HER4 722 (SEQ ID No: 77) and HER722Y1V9 (SEQ ID No: 75); HER1 722 (SEQ ID No: 78) and HER722Y1V9 (SEQ ID No: 75); HER2 845 (SEQ ID No: 79) and HER845Y1 (SEQ ID No: 80); HER3 845 (SEQ ID No: 81) and HER845Y1 (SEQ ID No: 80); HER2 904 (SEQ ID No: 82) and HER904Y1 (SEQ ID No: 83); HER4 904 (SEQ ID No: 84) and HER904Y1 (SEQ ID No: 83); HER2 933 (SEQ ID No: 85) and HER933Y1 (SEQ ID No: 86); HER1 933 (SEQ ID No: 87) and HER933Y1 (SEQ ID No: 86); HER2 945 (SEQ ID No: 88) and HER945Y1 (SEQ ID No: 90); HER3 945 (SEQ ID No: 89) and HER945Y1 (SEQ ID No: 90)-; HER4 945 (SEQ ID No: 91) and HER945Y1 (SEQ ID No: 90); and HER1 945 (SEQ ID No: 92) and HER945Y1 (SEQ ID No: 90).