Patent ID: 6066732
Filing Date: 2000-05-23
Classification: C07D

Abstract:
Process for the preparation of a 4(3H)-X-7H-pyrrolo[2,3-d]pyrimidine in which X is .dbd.O or .dbd.NH which comprises (i) treating a 6-amino-4(3H)-X-pyrimidine in an inert solvent with a 1-nitroalk-1-ene which is unsubstituted or substituted in the 2-position to yield the corresponding 5-(1-nitroalk-2-yl)-6-amino-4(3H)-X-pyrimidime; (ii) converting said 5-(1-nitroalk-2-yl)-6-amino-4(3H)-X-pyrimidine to the corresponding 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyrimidine; and (iii) removing the elements of water from said 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyrimidine to effect cyclization and form said 4(3H)-X-7H-pyrrolo[2,3-d]pyrimidine.