Patent ID: 6136322
Filing Date: 2000-10-24
Classification: A61K,C07K,C12N,Y02A

Abstract:
A live hepatitis A virus deletion mutant having a deletion mutation in the 5' nontranslated region of the viral genome, wherein said deletion mutation is selected from the group consisting of:(a) .DELTA.99-115 deletion mutants;(b) .DELTA.99-130 deletion mutants:(c) .DELTA.142 deletion mutants;(d) .DELTA.143 deletion mutants;(e) .DELTA.144 deletion mutants;(f) .DELTA.141-142 deletion mutants;(g) .DELTA.142-143 deletion mutants;(h) .DELTA.143-144 deletion mutants;(i) .DELTA.141-143 deletion mutants;(j) .DELTA.143-144 deletion mutants;(k) .DELTA.140-144 deletion mutants;(l) .DELTA.96-141 deletion mutants;(m) .DELTA.99-144 deletion mutants;(n) .DELTA.116-144 deletion mutants; and(o) .DELTA.131-144 deletion mutants.