Patent ID: 6242198
Filing Date: 2001-06-05
Classification: A61K,A61P

Abstract:
A method for treating a disorder that is decreased blood flow or nutrient supply to retinal tissue or optic nerve, or retinal ischemia or trauma, or optic nerve injury, comprising selecting a mammal in need of treatment for the disorder and administering to the mammal an effective amount of a compound of the following Formula II: ##STR19##wherein R, R.sup.1 and R"" are independently a C.sub.1 -C.sub.8 alkyl group, a C.sub.2 -C.sub.8 alkenyl group, C.sub.2 -C.sub.8 alkynyl group, cycloalkyl group, cycloalkyl group substituted by one or more substituents, cycloalkenyl group, cycloalkenyl group substituted with one or more substituents, carbocyclic aryl group, carbocyclic aryl group substituted by one or more substituents, alkaryl group, alkaryl group substituted by one or more substituents, heterocyclic group, heterocyclic group substituted by one or more substituents, heteroaryl group, or a heteroaryl group substituted by one or more substituents;or a physiologically acceptable salt thereof;wherein said substituent is chloro, fluoro, bromo, iodo, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, cyano, C.sub.3 -C.sub.15 dialkylaminoalkyl, carboxy, carboxamido, C.sub.1 -C.sub.8 alkylthio, allyl, aralkyl, alkaryl, C.sub.3 -C.sub.6 cycloalkyl, aroyl, aralkoxy, C.sub.2 -C.sub.8 acyl, aryl, heteroaryl, an aryl fused to a benzene ring, a heteroaryl fused to a benzene ring, C.sub.3 -C.sub.6 heterocycloalkyl, a C.sub.3 -C.sub.6 heterocycloalkyl ring fused to a benzene ring, C.sub.1 -C.sub.8 alkylsulfonyl, arylthio, amino, C.sub.1 -C.sub.8 alkylamino, C.sub.2 -C.sub.15 dialkylamino, hydroxy, hydroxyalkyl, carbamoyl, C.sub.1 -C.sub.8 N-alkylcarbamoyl, C.sub.2 -C.sub.15 N,N'-dialkylcarbamoyl, nitro, azido or a C.sub.2 -C.sub.15 dialkylsulfamoyl.