Patent ID: 7129332
Filing Date: 2006-10-31
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polypeptide comprising an antibody heavy chain variable region (“VH”) and an antibody light chain variable region (“VL”), each region comprising three complementarity determining regions (“CDRs”), which CDRs of each region are numbered sequentially CDR1 to CDR3 starting from the amino terminus, the polypeptide when made into an immunotoxin with a Pseudomonas exotoxin A or cytotoxic fragment thereof (“PE”) forming an immunotoxin which binds to epidermal growth factor receptor type III (“EGFRvIII”) antigen and which has a cytotoxicity to cells expressing said antigen at least equal to the cytotoxicity to said cells of an immunotoxin of parental antibody MR1 (SEQ ID NO.:18) and said PE, and a higher yield, when made into an immunotoxin with said PE, than that of MR1 when made into an immunotoxin with said PE, wherein: (a) CDRs 1–3, respectively of the V (b) CDRs 1–3, respectively, of the V