Patent ID: 6147063
Filing Date: 2000-11-14
Classification: A61P,C07C,C07D

Abstract:
A method of inhibiting NMDA receptor-ion channel related neurotoxicity or susceptible thereto in a mammal exhibiting such neurotoxicity comprising administering to the mammal an effective amount of a compound of the following formula I: ##STR9## wherein R is substituted or unsubstituted carbocyclic aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heteroaromatic or heterocyclic group having 1 to 3 rings, 3 to 8 ring members in each ring and 1 to 3 heteroatoms;R.sup.1 and R.sup.2 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylthio, substituted or unsubstituted aminoalkyl, substituted or unsubstituted carbocyclic aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heteroaromatic or heteroalicyclic group having 1 to 3 rings, 3 to 8 ring members in each ring and 1 to 3 hetero atoms;R.sup.3, R.sup.4, and each R.sup.5 substituent are each independently halogen, azido, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylthio, substituted or unsubstituted aminoalkyl, substituted or unsubstituted carbocyclic aryl, or substituted or unsubstituted aralkyl; n is an integer of from 0-3; or a pharmaceutically acceptable salt thereof, with the exclusion of N-(2,4-di-iodo-5-hydroxyphenyl)-N'-(2-tolyl)-guanidine and N-(2-methoxy-5-ethylphenyl)-N'-naphthylguanidine.