Patent ID: 6559134
Filing Date: 2003-05-06
Classification: A61K

Abstract:
A process for producing a solid preparation, comprising:pulverizing a low-substituted hydroxypropyl cellulose containing a hydroxypropoxyl group in an amount of 5.0 to 16.0 wt % having a loose bulk density of 0.40 g/ml or greater as determined by uniformly feeding a sample downwards from a height of 23 cm to a cylindrical container of 5.03 cm in diameter and 5.03 cm in height through a 24 mesh JIS sieve, leveling the upper surface and weighing the sample, a tapped bulk density of 0.60 g/ml or greater as determined by placing a cap on the container, adding additional sample up to an upper edge of the cap and tapping from a height of 1.8 cm 180 times, removing the cap and leveling and weighing the sample, and a volume avenge particle size as measured by dry laser diffraction of 30 &mgr;m or less to form low-substituted hydroxypropyl cellulose having an average particle size of 25 &mgr;m or less; and mixing the low-substituted hydroxypropyl cellulose with an average particle sin of 25 &mgr;m or loss with a sugar or sugar alcohol or both.