Patent ID: 6233471
Filing Date: 2001-05-15
Classification: A61B

Abstract:
A method for measuring an analyte present in a biological system, said method comprising:(a) transdermally extracting the analyte from the biological system using a sampling system that is in operative contact with a skin or mucosal surface of said biological system;(b) obtaining a raw signal from the extracted analyte, wherein said raw signal is related to analyte concentration;(c) subjecting the raw signal obtained in step (b) to a conversion step in order to convert said raw signal to an initial signal output which is indicative of the amount of analyte extracted by the sampling system;(d) performing a calibration step which converts the initial signal output obtained in step (c) to a measurement value indicative of the concentration of analyte present in the biological system at the time of extraction; and(e) repeating steps (a)-(c) at least once to obtain a plurality of measurement values, wherein the sampling system is maintained in operative contact with the skin or mucosal surface of said biological system to provide for analyte measurement.