Patent ID: 6403771
Filing Date: 2002-06-11
Classification: A61K

Abstract:
A method for producing a therapeutic radioconjugate of a targeting moiety bound, directly or indirectly, to at least one relatively short lived &agr;-particle emitting radioisotope, said targeting moiety being effective to deliver said radioconjugate to a pathological site in vivo, said pathological site comprising a target moiety, said targeting moiety and said target moiety constituting a specific binding pair, said method comprising loading onto a binding medium a relatively long lived radioisotope, the decay sequence of said relatively long lived radioisotope yielding daughter isotopes that emit predominantly &agr;- and/or &bgr;-particles, eluting said &agr;-particle emitting isotope from said binding medium and coupling said &agr;-particle emitting isotope, substantially free of said relatively long lived radioisotope, to said targeting moiety, wherein said relatively long lived radioisotope is 225Ac and said &agr;-article emitting isotope is 213Bi.