Patent ID: 7846453
Filing Date: 2010-12-07
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A method of activating tyrosine phosphorylation of ErbB4 in an ErbB4-expressing cell, comprising administering to said cell (a) a polypeptide comprising the amino acid sequence of neuregulin 3 (NRG3) encoded by SEQ ID NO:1, SEQ ID NO: 5, or SEQ ID NO: 22; (b) a polypeptide comprising the amino acid sequence of neuregulin 3 (NRG3) of SEQ ID NO:2, SEQ ID NO:6, or SEQ ID NO: 23; (f) a soluble form of the polypeptide (a) or polypeptide (b), having a transmembrane domain that cannot anchor the polypeptide in a cell membrane; and that activates receptor tyrosine phosphorylation of the ErbB4 receptor.