Patent ID: 6465250
Filing Date: 2002-10-15
Classification: A61K,C12N,C12Y,Y02P

Abstract:
A compound 8 to 50 nucleobases in length targeted to nucleobases 10 through 29, nucleobases 55 through 74, or nucleobases 124 through 143 of a 5â€²-untranslated region, nucleobases 279 through 1099 of a coding region, or nucleobases 1152 through 2140 of a 3â€²-untranslated region of a nucleic acid molecule encoding human Protein Phosphatase 2 catalytic subunit alpha of SEQ ID NO: 17, an intron region of a nucleic acid molecule encoding human Protein Phosphatase 2 catalytic subunit alpha of SEQ ID NO: 18, nucleobases 111 through 130 of a 5â€²-untranslated region, nucleobases 265 through 284, nucleobases 291 through 320, nucleobases 475 through 514, nucleobases 550 through 569, nucleobases 607 through 626, nucleobases 662 through 691, nucleobases 768 through 797, nucleobases 863 through 900, nucleobases 925 through 944, nucleobases 970 through 989, nucleobases 998 through 1027, or nucleobases 1066 through 1085 of a coding region, or nucleobases 1138 through 1693 of a 3â€²-untranslated region of a nucleic acid molecule encoding mouse Protein Phosphatase 2 catalytic subunit alpha of SEQ ID NO: 10, wherein said compound specifically hybridizes with one of said regions and inhibits the expression of one of said human of mouse Protein Phosphatase 2 catalytic subunit alpha nucleic acid molecules.