Patent ID: 8945611
Filing Date: 2015-02-03
Classification: A01N,A61K,A61P

Abstract:
1. A capsule dispersion of artificial oxygen carriers for use as a blood substitute, wherein the dispersion contains capsules with reversible oxygen storage capacity, wherein the capsules comprise an oxygen-permeable capsule material that contains or encloses fluorinated hydrocarbons, wherein the capsule dispersion is storage stable and the capsules have a diameter in the range of 50 to 1,000 nm, wherein the oxygen-permeable capsule material comprises an oxygen-permeable organic polymer, wherein the polymer is selected from the group of poly(lactide-co-glycolides) and polyalkylcyanoacrylates and mixtures thereof wherein the oxygen-permeable capsule material contains no sulphide bridges and has a coherent structure, wherein the weight ratio of oxygen-permeable capsule material to fluorinated hydrocarbons in the capsules is in the range of from 75:25 to 10:90, wherein the fluorinated hydrocarbons have molecular weights in the range from 250 to 2000 g/mole and are in liquid form, wherein the dispersion contains the capsules in volume-related quantities from 1-70% by volume relative to the dispersion, wherein the dispersion is adjusted to a physiological pH value, wherein the dispersion has a specific viscosity η in the range from 0.1 to 1.8 relative to temperatures in the range from 10° C. to 40° C., and wherein the dispersion is an aqueous-based dispersion and contains water as the continuous phase in the form of a physiological and isotonic sodium chloride solution.