Patent ID: 8119132
Filing Date: 2012-02-21
Classification: A61K,A61P,C07K

Abstract:
1. An isolated humanized antibody against tumor-associated glycoprotein-72 (TAG-72), which comprises (i) a heavy chain variable region having the amino acid sequence of SEQ ID NO:1, with the exception that amino acid 100 of SEQ ID NO:1 is selected from the group consisting of leucine (Leu) and tryptophan (Trp), amino acid 101 of SEQ ID NO:1 is selected from the group consisting of isoleucine (Ile), valine (Val), leucine (Leu) and alanine (Ala), amino acid 102 of SEQ ID NO:1 is selected from the group consisting of methionine (Met) and glutamine (Gln), and amino acid 103 of SEQ ID NO:1 is selected from the group consisting of alanine (Ala), glutamine (Gln) and glycine (Gly), and (ii) a light chain variable region having the amino acid sequence of SEQ ID NO: 21.