Patent ID: 6407120
Filing Date: 2002-06-18
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: wherein:K is phenyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, each ring optionally substituted with one to three substituents selected from halogen, C1-C3 alkyl, C1-C3 perfluoroalkyl, C1-C3 alkoxy and C1-C3 perfluoroalkoxy; L is H, C3-C8 cycloalkyl, â€ƒphenyl, 2-pyridyl, 3-pyridyl or 4pyridyl; wherein each phenyl and pyridyl ring may be substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy and halogen;Z is â€”COR3, â€”CONR1R2, â€”NR1R2 and SO2R4; X and Y are CH or N, with the proviso that one of X and Y must be CH; n is an integer from 0 to 3; m and p are independently selected from the integers 1 to 3; Q is O, NR, CHR; R is hydrogen or C1-C6 alkyl; R1 and R2 are independently selected from hydrogen, C1-C6 alkyl, (CH2)m phenyl, (CH2)m pyridyl, or R1 and R2 may be taken together with the nitrogen to which they are attached to form a 4 to 8 numbered ring optionally containing O, NH or NR; R3 is C1-C6 alkyl; R4 is â€”NR1R2, R3 is C1-C6 alkyl; R4 is â€”NR1R2, â€ƒâ€”NH(CH2)m phenyl, â€”N(C4-C8 cycloalkyl)2 and â€”NH(C4-C8 cycloalkyl); or a pharmaceutically acceptable salt thereof; and with the provisos that:when n is zero, K and L are phenyl, and both of X and Y are carbon, then Z is not â€”N(C2H5)2; when K is phenyl, L is not hydrogen; when K and L are both phenyl and both X and Y are CH, then Z is not CONR1R2 or SO2NR1R2, wherein R1 and R2 are hydrogen or C1-C6 alkyl; and when n is O, K is phenyl, L is cyclohexane and both X and Y are CH, then Z is not SO2NH2.