Patent ID: 6265406
Filing Date: 2001-07-24
Classification: C07D,F01M

Abstract:
A compound of Formula (I): ##STR70##or a stereoisomer or pharmaceutically acceptable salt thereof, wherein:A is O or S;W is N or CR.sup.3 ;X is N or CR.sup.3a ;Y is N or CR.sup.3b ;Z is N or CR.sup.3c ;provided that the number of W, X, Y, and Z which are N, is one or two;R.sup.1 is cyclopropyl or C.sub.1-3 alkyl substituted with 3-7 halogen;R.sup.2 is selected fromC.sub.1-6 alkyl substituted with 0-2 R.sup.4,C.sub.2-5 alkenyl substituted with 0-2 R.sup.4,C.sub.2-5 alkynyl substituted with 0-1 R.sup.4,C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.5,phenyl substituted with 0-2 R.sup.5, and3-6 membered heterocyclic system containing 1-3 heteroatoms selected from O, N, and S, substituted with 0-2 R.sup.5 ;R.sup.3 is selected from H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;R.sup.3a is selected from H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;alternatively, R.sup.3 and R.sup.3a, when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form --O--CH.sub.2 --O--, --O--CH.sub.2 --CH.sub.2 --O--, or --CH.dbd.CH--CH.dbd.CH--;R.sup.3b is selected from H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;alternatively, R.sup.3a and R.sup.3b, when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form --O--CH.sub.2 --O--, --O--CH.sub.2 --CH.sub.2 --O--, or --CH.dbd.CH--CH.dbd.CH--;R.sup.3c is selected from H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;alternatively, R.sup.3b and R.sup.3c, when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form --O--CH.sub.2 --O--, --O--CH.sub.2 --CH.sub.2 --O--, or --CH.dbd.CH--CH.dbd.CH--;R.sup.4 is selected fromC.sub.1-6 alkyl substituted with 0-2 R.sup.5,C.sub.3-10 carbocycle substituted with 0-2 R.sup.5,phenyl substituted with 0-5 R.sup.5, and a5-10 membered heterocyclic system containing 1-3 heteroatoms selected from O, N, and S, substituted with 0-2 R.sup.5 ;R.sup.5, at each occurrence, is independently selected from C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;Q.sup.1 and Q.sup.2 are independently selected fromH, --CHO, --CO.sub.2 R.sup.7, --CH.sub.2 OR.sup.7, --COR.sup.7, --NO.sub.2, --NH.sub.2, --NHR.sup.7, --N(R.sup.7).sub.2, --NHCO.sub.2 R.sup.7, --NHCOR.sup.7, --OR.sup.7, --OCOR.sup.7,C.sub.1-3 alkyl substituted by 3-7 halogens;C.sub.1-6 alkyl substituted with 0-2 R.sup.8,C.sub.2-6 alkenyl substituted with 0-2 R.sup.8, andC.sub.2-6 alkynyl substituted with 0-2 R.sup.8,alternatively, Q.sup.1 and Q.sup.2 can be taken together to form .dbd.O;alternatively, Q.sup.1 and Q.sup.2 can be taken together to form:a 3-6 membered spirocyclic ring, said spirocyclic ring containing 0, 1, or 2 oxygen atoms;R.sup.7 is selected fromH,C.sub.1-6 alkyl substituted with 0-2 R.sup.8,C.sub.2-6 alkenyl substituted with 0-2 R.sup.9,C.sub.2-6 alkynyl substituted with 0-1 R.sup.9,C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.9,phenyl substituted with 0-5 R.sup.9, andC.sub.1-3 alkyl substituted by 3-7 halogens;R.sup.8 is selected fromC.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.9,phenyl substituted with 0-5 R.sup.9,5-10 membered heterocyclic system containing 1-3 heteroatoms selected from O, N, and S, substituted with 0-2 R.sup.9 ; and,R.sup.9 is selected from C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, --SO.sub.2 NR.sup.14 R.sup.15, and C.sub.1-3 alkyl substituted by 3-7 halogens;R.sup.14 and R.sup.15 are independently selected from H and C.sub.1-4 alkyl;alternatively, R.sup.14 and R.sup.15, together with the nitrogen to which they are attached, combine to form a 5-6 membered ring containing 0-1 Oxygen atoms;R.sup.16 is selected from H, OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and NR.sup.14 R.sup.15 ;R.sup.17 is selected from C.sub.1-3 alkyl and C.sub.1-3 alkoxy; andR.sup.18 is selected from C.sub.1-4 alkyl and phenyl.