Patent ID: 6235779
Filing Date: 2001-05-22
Classification: A61K,A61P,Y10S

Abstract:
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula III: ##STR26##wherein:A=CO.sub.2 R, CONR.sup.1 R.sup.2, CH.sub.2 OR.sup.3, or CH.sub.2 NR.sup.4 R.sup.5 ; where R=H or cationic salt moiety, or CO.sub.2 R=ophthalmically acceptable ester moiety; R.sup.1, R.sup.2 =same or different=H or alkyl; R.sup.3 =H, acyl, or alkyl; R.sup.4, R.sup.5 =same or different=H, acyl, or alkyl, with the proviso that if one of R.sup.4, R.sup.5 =acyl, then the other=H or alkyl;n=0 or 2;L=OR.sup.6 in the .alpha. configuration, where R.sup.6 =H, alkyl, or acyl; ##STR27##where R.sup.7 =H, alkyl, acyl;-- -- -- =single or trans double bond;D, D.sup.1 =different=H and OR.sup.8, where R.sup.8 =H, alkyl, acyl;X=(CH.sub.2).sub.m or (CH.sub.2).sub.m O, where m=1-6; andY=a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; orX-Y=(CH.sub.2).sub.p Y.sup.1 ; where p=0-6; and ##STR28##wherein:W=CH.sub.2, O, S(O).sub.q, NR.sup.9, CH.sub.2 CH.sub.2, CH.dbd.CH, CH.sub.2 O, CH.sub.2 S(O).sub.q, CH.dbd.N, or CH.sub.2 NR.sup.9 ; where q=0-2, and R.sup.9 =H, alkyl, or acyl;Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy; and-- -- --=single or double bond;with the proviso that if:L=OR.sup.6 in the .alpha. configuration, where R.sup.6 is as defined above; ##STR29##where R.sup.7 is as defined above;-- -- --=trans double bond;D, D.sup.1 =different=H and OR.sup.8, where R.sup.8 is as defined above; andX=CH.sub.2 CH.sub.2 or CH.sub.2 O; thenY.noteq.a phenyl ring, optionally substituted with halo.