Patent ID: 8377680
Filing Date: 2013-02-19
Classification: C12N,C12P

Abstract:
1. A non-naturally occurring microbial organism comprising a hexamethylenediamine pathway and at least two exogenous nucleic acids encoding a hexamethylenediamine pathway enzyme expressed in a sufficient amount to produce hexamethylenediamine, said hexamethylenediamine pathway comprising: (A) 6-aminocaproate N-acetyltransferase; (B) 6-acetamidohexanoate kinase; (C) [(6-acetamidohexanoyl)oxy]phosphonate (6-AAHOP) oxidoreductase; (D) 6-acetamidohexanal aminotransferase or 6-acetamidohexanal oxidoreductase (aminating); and (E) 6-acetamidohexanamine N-acetyltransferase or 6-acetamidohexanamine hydrolase (amide).