Patent ID: 6441180
Filing Date: 2002-08-27
Classification: A61P,C07D

Abstract:
A tetrazole selected from the group consisting of a compound of the formula: whereinone of R1 or R2 is â€ƒand the other is hydrogen, halogen, lower alkyl sulfonyl, perfluoro-lower alkyl, cyano, or nitro; R3 is cycloalkyl; R4 is a six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which heteroaromatic ring contains from 1 to 3 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen with a first heteroatom being nitrogen adjacent to the connecting ring carbon atom, said heteroaromatic ring being unsubstituted or monosubstituted with halogen at a position on a ring carbon atom other than that adjacent to said connecting carbon atom; R5 is lower alkyl, or perfluoro lower alkyl; R6 is hydrogen or lower alkyl; n is 0 or 1; &Dgr; denotes a trans configuration across the double bond; and a pharmaceutically acceptable salt thereof.