Patent ID: 6469038
Filing Date: 2002-10-22
Classification: C07D

Abstract:
Compounds having the Formula I wherein* denotes a first chiral center when R3 and R4 are different; @ denotes a second chiral center; R1 and R2 are independently hydrogen, C1-C8alkyl, C3-C7cycloalkyl, C1-C8substituted alkyl, C1-C6alkoxy, hydroxy, C3-C7cycloalkenyl, C3-C7substituted cycloalkenyl, C3-C7substituted cycloalkyl, â€”(CH2)n-aryl, â€”(CH2)n-substituted aryl, C2-C8alkenyl, C2-C8substituted alkenyl, or â€”(CH2)nâ€”C3-C7cycloalkyl, provided that R1 and R2 are not both hydrogen; R3, R5, and R6 are independently hydrogen or C1-C8alkyl; R4 is thiazolyl; Y is â€”(CH2)nâ€”, â€”O(CH2)nâ€”, â€”(CH2)nOâ€”, â€”N(R7)(CH2)nâ€”, â€”(CH2)nN(R7)â€”, â€”S(CH2)nâ€”, â€”(CH2)nSâ€”, â€”C&boxH;Câ€”, or â€”Câ‰¡Câ€”; R7 is hydrogen, methyl, or ethyl; Z is aryl, substituted aryl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, or C1-C8alkyl; each n is 0 to 5, and the substituents mentioned above are selected from halogen, C1-C8 alkyl, CN, CF, NO2, NH2, NHC1-C8 alkyl, N(C1-C8 alkyl)2, OC1-C8 alkyl and OH, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof.