Patent ID: 6664269
Filing Date: 2003-12-16
Classification: A61K,A61P,C07D

Abstract:
A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein:A and B together represent a fused benzene ring which is optionally substituted with one or more substituents selected from the group consisting of halo, nitro, hydroxy, ether, thiol, thioether, amino, C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl; wherein one or more of the substituents may together form a ring; the dotted line between the 3 and 4 positions indicates the optional presence of a double bond; one of RC1 and RC2 is represented by -L-RL, and the other of RC1 and â€”RC2 is H, where L is of formula: â€”(CH2)n1â€”â€ƒwherein n1 is 1 or 2, and wherein RL is selected from optionally substituted C5-20 aryl; and RN is hydrogen.