Patent ID: 6376491
Filing Date: 2002-04-23
Classification: A61P,C07D,C07F

Abstract:
A method for the treatment or prevention of mycosis in mammals comprising administering a therapeutically effective amount of a compound of the formula: whereinR1 is hydrogen, an unsubstituted or substituted heterocyclic ring, R2 is hydrogen, unsubstituted or substituted lower alkyl, aralkyl, cycloalkyl or cycloalkylalkyl; R3, R4 and R5 are independently hydrogen or halogen; R6 and R7 are independently hydrogen, unsubstituted or substituted lower alkyl, an aromatic ring or aliphatic ring which may contain heteroatom(s); or R6 and R7 form an aliphatic ring which may contain further heteroatom(s) together with the adjacent Q2, N and Q3; or Q1 and R6 form an aliphatic ring which may contain further heteroatom(s) together with the adjacent N and Q2; R8, R9 and R10 are independently hydrogen, unsubstituted or substituted lower alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, an aromatic ring or aliphatic ring which may contain heteroatom(s); or R9 and R10 form an aliphatic ring which may contain further heteroatom(s) together with the adjacent nitrogen; Q1 is unsubstituted or substituted lower alkylene other than unsubstituted or substituted methylene; Q2 and Q3 are each independently a single bond, tinsubstituted or substituted lower alkylene; Q4 is a single bond, carbonyl, oxime, oxime O-ether which has a substituted or unsubstituted lower alkyl, lower alkenyl, aralkyl or aryl radical on the oxygen atom, or unsubstituted or substituted lower alkylene; Q5 is a single bond or carbonyl and x is an integer of 0 to 2; with the proviso that when R1 is â€”COOC2H5, then or the pharmaceutically acceptable salts thereof.