Patent ID: 7521175
Filing Date: 2009-04-21
Classification: A61P,C07K,C12Q,G01N

Abstract:
1. A method of determining whether a test compound binds a mutant Bcr-Abl polypeptide; wherein the mutant Bcr-Abl polypeptide comprises a M244V, T277A, T277P, M278K, M278L, V304D, V304A, F317L, E355G, F359C, F359I, F359V, L364I, L364H, V379I, H396R or H396K amino acid substitution in the Bcr-Abl polypeptide sequence shown in SEQ ID NO: 1, the method comprising the steps of: contacting the mutant Bcr-Abl polypeptide with a test compound under conditions favorable to binding and determining whether the test compound binds to the mutant Bcr-Abl polypeptide.