Patent ID: 8669354
Filing Date: 2014-03-11
Classification: B82Y,C08F,C08L,H01F

Abstract:
1. A method of selectively removing endotoxin from a protein preparation, comprising the steps of: (a) adding a plurality of core-shell nanoparticles to a protein preparation comprising endotoxin and a plurality of proteins; (b) incubating the core-shell nanoparticles with the protein preparation thereby binding the majority of endotoxin to the core-shell nanoparticles while not binding the majority of the plurality of proteins to the core-shell nanoparticles; and (c) separating the endotoxin bound to the core-shell nanoparticles from the plurality of proteins of the protein preparation not bound to the core-shell nanoparticles; wherein, at least 93.5% of the endotoxin is removed from the protein preparation.