Patent ID: 8614181
Filing Date: 2013-12-24
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition which comprises a glucagon-like peptide, wherein said pharmaceutical composition is prepared with a method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide, a pharmaceutically acceptable buffer and a pharmaceutically acceptable preservative, the method comprising preparing said pharmaceutical composition from a bulk glucagon-like peptide product which has been subjected to treatment at a pH in the range from 8.5 to 11.5 prior to freeze drying, and freeze drying the bulk glucagon-like peptide, wherein the pH of the pharmaceutical composition ranges from pH 7.0 to pH 8.5 and wherein the pharmaceutical composition is shelf stable as measured by a less than two fold increase of fluorescence in a Thioflavin T test of the glucagon-like peptide contained in said composition after storage of the composition for one month at 37° C.