Patent ID: 6022521
Filing Date: 2000-02-08
Classification: A61K,A61N

Abstract:
method of establishing the optimal effective radiation dose in mCi for treatment of disease in a patient, said method comprising the steps of:approximately identifying the fat and lean components of the patient;administering to the patient a tracer dose of a radiolabeled antibody;establishing the rate of clearance of said tracer dose from the patient's body by direct measurement across multiple time points using a radiation detection device;calculating a geometric mean representing an average number of counts of detected radiation;plotting the percent of injected activity versus the calculated time from infusion on a graph;determining from said graph the effective half-life value of said tracer dose in the patient;determining the actual amount of therapeutic mCi per coy based on the effective half-life of said tracer and said weight of the patient in view of said fat and lean components; andmultiplying said actual amount of therapeutic mCi per cGy by the amount of desired cGy to be delivered to calculate the total therapeutic mCi dose to be administered to the patient.