Patent ID: 7041320
Filing Date: 2006-05-09
Classification: A61K

Abstract:
1. A method of making coated microparticles comprising mixing a biodegradable polymer, buprenorphine, methylene chloride and dimethyl sulfoxide to form an organic phase, mixing the organic phase with an aqueous phase to form an emulsion, maintaining the emulsion for a period of time sufficient to form hardened microparticles, recovering the microparticles, and coating the microparticles with a coating polymer to form a polymer coating in an amount between 0.1 to 85 percent by weight of the microparticles wherein the biodegradable polymer is a member selected from the group consisting of D or L optically active forms or DL optically inactive forms of poly-lactide (PLA), poly-lactide-co-glycolide (PLA-PGA) polymers and poly-L-lactide-co-caprolactone (PLA-PCL) polymers.