Patent ID: 6022985
Filing Date: 2000-02-08
Classification: A61P,C07D

Abstract:
A process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.,10.beta.-trihydro xy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, comprisingcrystallizing said 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.,10.beta.-trihydro xy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms, and thendrying the product obtained under defined conditions of temperature, pressure, and humidity.