Patent ID: 7772385
Filing Date: 2010-08-10
Classification: C07K

Abstract:
1. A nucleic acid construct encoding a chimeric T1R1 taste receptor polypeptide comprising a first polypeptide that is at least 90% identical to the entire extracellular domains of the human T1R1 polypeptide in SEQ ID NO:17 and a second polypeptide that is at least 90% identical to the transmembrane domains of another GPCR polypeptide wherein said another GPCR is endogenous (wild-type) full length human or rodent T1R1, T1R2 or T1R3 taste receptor polypeptide other than human T1R1 or a GPCR polypeptide other than a T1R taste receptor polypeptide and wherein a taste receptor comprising said chimeric T1R1 taste receptor polypeptide specifically binds or functionally responds to taste ligands that specifically bind or modulate the activity of a taste receptor comprising the endogenous T1R1 polypeptide in SEQ ID NO:17.