Patent ID: 6599925
Filing Date: 2003-07-29
Classification: A61P,C07D

Abstract:
A compound of formula 1:wherein: R, R1, R2, and R3 are independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, â€”CH2â€”(C3-C6 cycloalkyl), C1-C6 alkanoyl, halo, hydroxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, amino, â€”NH(alkyl of 1-6 carbon atoms), â€”N(alkyl of 1-6 carbon atoms)2, or perfluoroalkoxy of 1-6 carbon atoms; R4 is hydrogen, alkyl of 1-6 carbon atoms, branched alkyl of 1-6 carbon atoms, perflouroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkenyl-aryl, â€”CH2R5, â€”CH(OH)R5, â€”C(O)R5, â€”CH(SH)R5, or â€”C(S)R5 or â€”(CH2)nâ€”C3 to C6 cycloalkyl wherein n is an integer of from 0 to 2; R5 is hydrogen, alkyl of 1-6 carbon atoms, branched alkyl of 1-6 carbon atoms, perflouroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkenyl-aryl or â€”(CH2)nâ€”C3 to C6 cycloalkyl wherein n is an integer of from 0 to 2; R6 is selected from hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, â€”CH2-cycloalkyl of 3 to 6 carbon atoms, alkylaryl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; n is an integer of 0-6; A is COOH, or an acid mimic; or a pharmaceutically acceptable salt or ester form thereof.