Patent ID: 7534352
Filing Date: 2009-05-19
Classification: B01J

Abstract:
1. A process for producing a chromatographic stationary phase for use in reversed-phase chromatography, comprising: providing an inorganic oxide support material comprising surface hydroxyl groups; reacting the surface hydroxyl groups with at least one endcapping reagent having a formula selected from the group consisting of formulas I, II, and III: wherein, R 1 is hydrogen or methyl, X is halogen, OR 2 or NR 3 R 4 , and Z is —NH— or —NR 5 —, wherein R 2 is C 1 to C 30 alkyl, R 3 and R 4 are independently hydrogen or C 1 to C 30 alkyl, and R 5 is methyl or ethyl, to provide a modified particulate support material having at least one endcap Si—H group; converting at least one endcap Si—H group to an endcap silanol group; and reacting the endcap silanol group with at least one silane coupling agent selected from the group consisting of formulas IV, V, VI, and VII: wherein R Y is halogen, OR m is 1 or greater; and n is 1 or greater to provide a functionalized particulate support material.