Patent ID: 6610734
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of Formula (I), or pharmaceutically acceptable salt thereof, wherein Formula (I) has the structure: wherein: R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, phenyl, substituted phenyl, and (CH2)n(1,3)dioxane, where n is 2 to 5; R3 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R4 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkylcycloalkyl, substituted alkylcycloalkyl, phenyl(substituted)alkyl, alkylOH, substituted alkylOH, alkylOBn, substituted alkylOBn, alkylpyridyl, substituted alkylpyridyl, alkylfuranyl, substituted alkylfuranyl, CH(OH)phenyl, CH(OH)substituted phenyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, N-substituted-piperidinyl, piperidinyl, substituted piperidinyl, tetrahydrothiopyran, substituted tetrahydrothiopyran, 2-indane, substituted 2-indane, phenyl, substituted phenyl, alkylNHR7, and substituted alkylNHR7; with the proviso that R3 and R4 are not both hydrogen; R7 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, benzyl, substituted benzyl, alkylOH, substituted alkylOH, alkylSR8, or substituted alkylSR8; R8 is alkyl, substituted alkyl, benzyl, or substituted benzyl; or R3 and R4 may be joined to form a ring; R5 is selected from the group consisting of hydrogen, lower alkyl, substituted lower alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, CH2cycloalkyl, substituted CH2cycloalkyl, benzyl, substituted benzyl, and CH2CH2QR9; Q is O, NH or S; R9 is lower alkyl, substituted lower alkyl, phenyl, or substituted phenyl; R6 is selected from the group consisting of hydrogen, halogen and CF3; T is selected from the group consisting of W, Y and Z are independently selected from the group consisting of C, CR10 and N; R10 is selected from the group consisting of hydrogen and halogen, with the proviso that at least one of W, Y and Z must be C; X is selected from the group consisting of O, S, SO2, and NR11; R11 is selected from the group consisting of hydrogen, lower alkyl, substituted lower alkyl, benzyl, substituted benzyl, phenyl, and substituted phenyl; provided that when the compound contains one or more chiral centers, at least one of the chiral centers must be of S-stereochemistry.