Patent ID: 6511974
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein:A, B, E, G are, independently, CH or nitrogen; D is, independently, Câ€”W or nitrogen; R1 is alkanoyl of 2 to 7 carbon atoms, a group selected from CN, COOH, CONH2, â€ƒor a moiety selected from the group of: â€ƒwith a proviso that, when A and B are both CH, R1 is not COOH; R2, R3 and R5 are, independently, hydrogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or perfluoroalkyl of 1 to 6 carbons; R4 is hydrogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkoxyalkyl of 2 to 7 carbon atoms, or an acyl substituent selected from the group consisting of alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, cycloalkanoyl of 3 to 7 carbon atoms; or a) aroyl, the aroyl groups being substituted by one or more substituents from the group of H, halogen, CN, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkoxy of 1 to 6 carbons, CF3, or phenyl; b) arylalkanoyl, the alkyl portion of the arylalkanoyl group being of 1 to 6 carbon atoms which is terminally substituted by an aryl group and the aryl group of the arylalkanoyl group being optionally substituted with one or more substituents selected from H, halogen, CN, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkoxy of 1 to 6 carbons, CF3, or optionally substituted phenyl wherein the substituents are selected from halogen, cyano, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, alkoxy of 1 to 6 carbons, or CF3; X and Y are, independently, hydrogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, perfluoroalkyl of 1 to 6 carbons, alkoxyalkyl of 2 to 7 carbon atoms, halogen, alkoxy of 1 to 6 carbons, or hydroxy; W is hydrogen, halogen, alkyl, alkoxyalkyl of 2 to 7 carbons, hydroxyalkyl of 1 to 6 carbons, or CH2NR6R7; R6 and R7 are, independently, hydrogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms; or, taken together with the nitrogen atom of CH2NR6R7, R6 and R7 form a five or six membered ring optionally containing one or more additional heteroatoms; R9 is independently hydrogen, trimethylsilyl or a straight chain alkyl of 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof.