Patent ID: 6759538
Filing Date: 2004-07-06
Classification: A61P,C07D

Abstract:
A compound according to structural formula (I): including the pharmaceutically acceptable salts, hydrates, solvates, N-oxides and prodrugs thereof, wherein:X and Y are each, independently of one another, N or O, provided that X and Y are not both O; Z is N or â€”CHâ€”, provided that Z is â€”CHâ€” when X and Y are both N; R2, R3, R4, R5, R6, R8, R9, R10 and R13 are each, independently of one another, selected from the group consisting of hydrogen, â€”OH, â€”SH, â€”CN, â€”NO2, halo, fluoro, chloro, bromo, iodo, lower alkyl, substituted lower alkyl, lower heteroalkyl, substituted lower heteroalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, lower haloalkyl, monohalomethyl, dihalomethyl, trihalomethyl, trifluoromethyl, lower alkylthio, substituted lower alkylthio, lower alkoxy, substituted lower alkoxy, methoxy, substituted methoxy, lower heteroalkoxy, substituted lower heteroalkoxy, cycloalkoxy, substituted cycloalkoxy, cycloheteroalkoxy, substituted cycloheteroalkoxy, lower haloalkoxy, monohalomethoxy, dihalomethoxy, trihalomethoxy, trifluoromethoxy, amino, lower di- or monoalkylamino, substituted lower di- or monoalkylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, phenoxy, substituted phenoxy, arylalkyl, substituted arylalkyl, arylalkyloxy, substituted arylalkyloxy, benzyl, benzyloxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylalkyl, substituted heteroarylalkyl, heteroarylalkyloxy, substituted heteroarylalkyloxy, carboxyl, lower alkoxycarbonyl, substituted lower alkoxycarbonyl, aryloxycarbonyl, substituted aryloxycarbonyl, arylalkyloxycarbonyl, substituted arylalkyloxycarbonyl, carbamate, substituted carbamate, carbamoyl, substituted carbamoyl, sulfamoyl, substituted sulfamoyl and a group of the formula â€”Lâ€”R14, where â€œLâ€  is a linker and R14 is cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl, provided that at least one of R2 or R6 is other than hydrogen; R11 is hydrogen or lower alkyl; and R12 is monohalomethyl or dihalomethyl, wherein the compound is not 2,2-dichloro-Nâ€”[3-[3-(2,6-dichlorophenyl-5-isoxazolylluhenyl] acetamide or 2,2-dichloro-Nâ€”[3-[3-(2,4-dichlorophenyl)-5-isoxazolylkhenyl] acetamide.