Patent ID: 6778853
Filing Date: 2004-08-17
Classification: A61M,A61N,C12M

Abstract:
A device for manipulating a molecule in vivo relative to a target tissue comprising:an elongated member comprising an elongated core electrode comprising a conductive material, a substantially nonconductive insulator sleeve positioned in surrounding relation to a portion of the core electrode, and an outer electrode positioned in surrounding relation to a portion of the sleeve, a bottom portion of the sleeve protruding therefrom; at least two discrete electrodes affixed in axially spaced relation along the elongated member, each electrode being in independent circuit communication with a respective portion of a source of electrical energy, the discrete electrodes being configured to establish a first electromagnetic field in vivo between selected electrodes sufficient to cause an electromigration of a molecule relative to a target tissue and a second electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue; and an insulating material interposed axially between the electrodes for achieving relative electromagnetic isolation of the electrodes.