Patent ID: 8084436
Filing Date: 2011-12-27
Classification: A61K,A61P,C07H,C12N,C12Q

Abstract:
1. A compound comprising a modified oligomeric compound, wherein the modified oligomeric compound is 10 to 30 nucleobases in length, specifically hybridizable with SEQ ID NO: 4, and 100% complementary to at least an 8 nucleobase portion of nucleotides 1100 to 1170 of SEQ ID NO: 4 encoding SGLT2, and wherein said modified oligomeric compound comprises: a gap segment consisting of linked deoxynucleosides; a 5′ wing segment consisting of linked nucleosides; and a 3′ wing segment consisting of linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment and wherein each of said nucleosides of each of said wing segments comprises a modified sugar.