Patent ID: 8603436
Filing Date: 2013-12-10
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A drug delivery molecule which comprises a. a bioactive molecule (BAM) which includes a nucleic acid designed to effect gene therapy for liver disorders and an expressed sequence tag (EST) that comprises a nucleic acid encoding a ligand-binding element from a plant auxin binding protein or an insect hormone binding protein, b. a targeting moiety, which is cycloDPhe-Cys-Phe-DTrp-Lys-Thr-Apa-Cys-Thr, where Apa is aminopentanoic acid, and which links to a somatostatin target receptor, and c. a routing sequence for causing delivery to a subcellular compartment in a cell having said targeted receptor, which sequence is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, and SEQ ID NO:33.