Patent ID: 8633188
Filing Date: 2014-01-21
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group, the carbocyclic group being substituted optionally with at least one selected from the group consisting of (A) the substituent α, the substituent α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, aryl, and heterocyclic group; (B) lower alkyl optionally substituted with one or more substituents selected from the group of substituent α; (C) amino lower alkyl substituted with one or more substituents selected from the group of substituent α; (D) hydroxyimino lower alkyl; (E) lower alkoxyimino lower alkyl; (F) lower alkenyl optionally substituted with one or more substituents selected from the group of substituent α; (G) lower alkynyl optionally substituted with one or more substituents selected from the group of substituent α; (H) lower alkoxy optionally substituted with one or more substituents selected from the group of substituent α; (I) lower alkylthio optionally substituted with one or more substituents selected from the group of substituent α; (J) lower alkylamino substituted with one or more substituents selected from the group of substituent α; (K) lower alkylsulfonyl optionally substituted with one or more substituents selected from the group of substituent α; (L) aryl lower alkoxycarbonyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (M) acyl substituted with one or more substituents selected from the group of substituent α; and the ring part of the carbocyclic carbonyl and the heterocyclic carbonyl is substituted optionally with at least one selected from the group of lower alkyl; the substituent group α; and lower alkyl substituted with at least one selected from the group of the substituent α; (N) cycloalkyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (O) lower alkylsulfinyl optionally substituted with one or more substituents selected from the group of substituent α; (P) sulfamoyl; (Q) aryl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (R) heterocyclic group optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (S) aryloxy optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (T) heterocyclicoxy optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (U) arylthio optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (V) heterocyclic thio optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (W) arylamino optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (X) heterocyclicamino optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (Y) aryl lower alkylamino optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (Z) heterocyclic lower alkylamino optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AA) lower alkyl sulfamoyl optionally substituted with one or more substituents selected from the group of substituent α; (AB) aryl sulfamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AC) heterocyclic sulfamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AD) arylsulfonyl substituted optionally with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AE) heterocyclic sulfonyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AF) aryl carbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AG) heterocyclic carbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AH) aryl lower alkylcarbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AI) heterocyclic lower alkylcarbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alky; (AJ) aryloxycarbonyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AK) heterocyclicoxycarbonyl optionally substituted with one or more substituents selected from the group of substituent α, azido, and lower alkyl; (AL) lower alkylenedioxy substituted optionally with halogen; (AM) oxo; (AN) azido; and (AO) one of the following formulae: wherein Q Q W W R R ring B is a carbocyclic group or a heterocyclic group, the carbocyclic group and the heterocyclic group being substituted optionally with at least one selected from the group consisting of the above (A) to (AM); (a) a substituent α, the substituent α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, aryl, and heterocyclic group; (b) lower alkyl optionally substituted with the substituent α; (c) amino lower alky substituted with the substituent α; (d) hydroxyimino lower alkyl; (e) lower alkoxyimino lower alkyl; (f) lower alkenyl optionally substituted with the substituent α; (g) lower alkynyl optionally substituted with the substituent α; (h) lower alkoxy optionally substituted with the substituent α; (i) lower alkylthio optionally substituted with the substituent α; (j) lower alkylamino substituted with the substituent α; (k) lower alkylsulfonyl optionally substituted with the substituent α; (l) aryl lower alkoxycarbonyl optionally substituted with one or more substituents selected from the group of substituent α and lower alkyl; (m) acyl substituted with the substituent α; and the ring part of the carbocyclic carbonyl and the heterocyclic carbonyl is substituted optionally with at least one selected from the group of lower alkyl; the substituent group α; and lower alkyl substituted with at least one selected from the group of the substituent α, (n) lower alkylsulfonyl optionally substituted with the substituent α; (o) sulfamoyl; (p) lower alkyl sulfamoyl optionally substituted with one or more substituents selected from the group of substituent α; (q) cycloalkyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (r) aryl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (s) heterocyclic group optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (t) aryloxy optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (u) heterocyclicoxy optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (v) arylthio optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (w) heterocyclic thio optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (x) arylamino optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (y) heterocyclic amino optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (z) aryl lower alkylamino optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (aa) heterocyclic lower alkylamino optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ab) arylsulfamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ac) heterocyclic sulfamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ad) arylsulfonyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ae) heterocyclic sulfonyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (af) arylcarbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ag) heterocyclic carbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ah) aryl lower alkylcarbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ai) heterocyclic lower alkylcarbamoyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (aj) aryloxy carbonyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (ak) heterocyclicoxycarbonyl optionally substituted with one or more substituents selected from the group of substituent α, azido and lower alkyl; (al) lower alkylenedioxy substituted optionally with halogen; and (am) oxo; Alk p is an integer of 1 or 2; Alk R X is O; R lower alkyl being substituted optionally with at least one selected from the group consisting of a substituent α, the substituent α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, aryl, and heterocyclic group, lower alkenyl being substituted optionally with the substituent α, amino being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, amidino being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, acyl being substituted optionally with the substituent α; and the ring part of the carbocyclic carbonyl and the heterocyclic carbonyl is substituted optionally with at least one selected from the group of lower alkyl; the substituent group α; and lower alkyl substituted with at least one selected from the group of the substituent α, carbamoyl being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, carbamoylcarbonyl being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, lower alkylsulfonyl being substituted optionally with the substituent α, arylsulfonyl being substituted optionally with at least one selected from the group consisting of the substituent α and a lower alkyl, and the carbocyclic group and the heterocyclic group being substituted optionally with at least one selected from the group consisting of the substituent α and lower alkyl; R lower alkyl being substituted optionally with at least one selected from the group consisting of a substituent α, the substituent α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, aryl, and heterocyclic group, lower alkenyl being substituted optionally with the substituent α, acyl being substituted optionally with the substituent α; and the ring part of the carbocyclic carbonyl and the heterocyclic carbonyl is substituted optionally with at least one selected from the group of lower alkyl; the substituent group α; and lower alkyl substituted with at least one selected from the group of the substituent α, lower alkoxycarbonyl being substituted optionally with the substituent α, amino being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, carbamoyl being substituted optionally with at least one selected from the group consisting of lower alkyl, acyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, a carbocyclic group and a heterocyclic group, and the carbocyclic group and the heterocyclic group being substituted optionally with at least one selected from the group consisting of the substituent α and a lower alkyl; n=0 or 2 and m=0 or 2; n+m is an integer of 2; each R R lower alkyl being substituted optionally with at least one selected from the group consisting of a substituent α, the substituent α being at least one selected from the group consisting of halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, acylamino, lower alkylamino, lower alkylthio, carbamoyl, lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, aryl, and heterocyclic group, lower alkenyl being substituted optionally with the substituent α, lower alkynyl being substituted optionally with the substituent α, and the carbocyclic group and the heterocyclic group being substituted optionally with at least one selected from the group consisting of the substituent α and a lower alkyl; wherein acyl includes aliphatic acyl of a carbon number of 1 to 10, carbocyclic carbonyl and heterocyclic carbonyl; when R wherein R s is an integer of 1 to 4; each R with the proviso that ring A being non-substituted phenyl is excluded when n+m is 2 and R or its pharmaceutically acceptable salt.