Patent ID: 6281215
Filing Date: 2001-08-28
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR27##in which:Ar is selected froma mono-, bi- or tricyclic aryl group having from 6 to 14 carbon atoms,a heteroaromatic group selected from the pyridyl, pyrimidyl, pyrrolyl, furyl, thienyl, quinolyl, indolyl, benzothienyl, benzofuryl, benzopyrranyl, benzothiopyrannyl, dibenzofuryl, carbazolyl and benzothiazinyl groups,optionally, the Ar group carrying 1 to 3 substituents selected from C.sub.1 -C.sub.8 alkyl, (C.sub.3 -C.sub.8)cyclo-alkyl (C.sub.1 -C.sub.6)alkyl, C.sub.1 -C.sub.8 alkoxy, (C.sub.3 -C.sub.8)cycloalkyloxy (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.8)cycloalkyl (C.sub.1 -C.sub.6)alkoxy (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.8)cycloalkyloxy, (C.sub.3 -C.sub.8)cycloalkyl (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxy (C.sub.1 -C.sub.6)alkyl, C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 heteroaryl, (C.sub.6 -C.sub.14)heteroaryl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl (C.sub.6 -C.sub.14)aryl, (C.sub.6 -C.sub.14)aryloxy, (C.sub.6 -C.sub.14)aryloxy, (C.sub.1 -C.sub.6)aryloxy (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.4)aryl (C.sub.1 -C.sub.6)alkyloxy or (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyloxy (C.sub.1 -C.sub.6)alkyl groups, a halogen, a trifluoromethyl, trifluoromethoxy, cyano, hydroxyl, nitro, amino, carboxyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, carbamoyl, (C.sub.1 -C.sub.8)alkylthio, (C.sub.1 -C.sub.8)alkylsulphinyl, (C.sub.1 -C.sub.8)alkylsulphonyl, sulphoamino, (C.sub.1 -C.sub.8)alkylsulphonylamino, sulphamoyl or (C.sub.1 -C.sub.8) alkylcarbonylamino group, or two substituents together forming a methylenedioxy group;R.sub.1, R.sub.2 and R.sub.3 are selected, independently of each other, from:a hydrogen atom,a C.sub.1 -C.sub.8 alkyl or (C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl group,a cycloalkyl group containing from 3 to 8 carbon atoms, a (C.sub.3 -C.sub.8)cycloalkyl(C.sub.1 -C.sub.6) alkyl group, a (C.sub.3 -C.sub.8)cycloalkyloxy(C.sub.1 -C.sub.6)alkyl or (C.sub.3 -C.sub.8)cycloalkyl(C.sub.1 -C.sub.6)-alkoxy(C.sub.1 -C.sub.6)alkyl group,a C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 heteroaryl, (C.sub.6 -C.sub.14)heteroaryl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl (C.sub.6 -C.sub.14)aryl (C.sub.6 -C.sub.14)aryl, (C.sub.1 -C.sub.6)alkoxy (C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.14)aryloxy (C.sub.1 -C.sub.6)alkyl group,or alternatively R.sub.1 forms with the nitrogen atom to which R.sub.1 is attached and the Ar group a ring selected from indolinyl, quinolyl, indolyl and tetrahydroquinolyl; andR.sub.4, R.sub.5, R.sub.6 are selected, independently of each other, from:a hydrogen atom,a C.sub.1 -C.sub.8 alkyl, (C.sub.3 -C.sub.8)cycloalkyl (C.sub.1 -C.sub.6)alkyl, C.sub.1 -C.sub.8 alkoxy, (C.sub.3 -C.sub.8)cycloalkyloxy (C.sub.6 -C.sub.6)alkyl, (C.sub.3 -C.sub.8)cycloalkyl (C.sub.1 -C.sub.6)alkoxy (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.8)cycloalkyloxy, (C.sub.3 -C.sub.8)cycloalkyl (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxy (C.sub.1 -C.sub.6)alkyl, C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 heteroaryl, (C.sub.6 -C.sub.14)heteroaryl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyl (C.sub.6 -C.sub.14)aryl, (C.sub.6 -C.sub.14)aryloxy, (C.sub.6 -C.sub.14)aryloxy (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyloxy or (C.sub.6 -C.sub.14)aryl (C.sub.1 -C.sub.6)alkyloxy (C.sub.1 -C.sub.6)alkyl groups, a halogen, a trifluoromethyl, trifluoromethoxy, cyano, hydroxyl, nitro, amino, (C.sub.1 -C.sub.6)alkoxycarbonyl, carbamoyl, (C.sub.1 -C.sub.8)alkylthio, (C.sub.1 -C.sub.8)alkylsulphinyl, (C.sub.1 -C.sub.8)alkylsulphonyl, sulphoamino, (C.sub.1 -C.sub.8)alkylsulphonylamino, sulphamoyl or (C.sub.1 -C.sub.8)alkylcarbonylamino group,optionally two of the R.sub.4, R.sub.5 and R.sub.6 groups together form a methylenedioxy group, andoptionally, each aryl group being substituted with 1 to 3 substituents selected from a C.sub.1 -C.sub.8 alkyl or C.sub.1 -C.sub.8 alkoxy group, a halogen, a trifluoromethyl, trifluoromethoxy, hydroxyl, nitro and amino group,wherein heteroaryl in each case is selected from the pyridyl, pyrimidyl, pyrrolyl, furyl, thienyl, quinolyl, indolyl, benzothienyl, benzofuryl, benzopyrranyl, benzothiopyrannyl, dibenzofuryl, carbazolyl and benzothiazinyl groups;solvates thereof and pharmaceutically acceptable salts thereof.