Patent ID: 7858633
Filing Date: 2010-12-28
Classification: A61K,A61P,C07D

Abstract:
1. A compound according to structural formula (I): or a salt or N-oxide thereof, wherein: R R R R wherein the electronegative group is selected from the group consisting of —CN, —NC, —NO each R each R each R each R each R the water-solubilizing group is of the formula: morpholino, piperidinyl, (C1-C6)N-alkyl piperidinyl, N-methyl piperidinyl, piperazinyl, (C1-C6)N-alkylpiperazinyl, N-methylpiperazinyl, N-ethyl piperidinyl, N-ethyl piperazinyl, pyrrolidinyl, N-alkyl pyrrolidinyl, N-methyl pyrrolidinyl, diazepinyl, N-ethyl pyrrolidinyl, N-alkyl azepinyl, N-methyl azepinyl, N-ethyl azepinyl, homopiperazinyl, N-methyl homopiperazinyl, N-ethyl homopiperazinyl, imidazoyl, where Y is selected from CH and N, Z is selected from CH 2 , O, S, N, NH, N—(CH 2 ) y —R a , N—(CH 2 ) y —C(O)R a , N—(CH 2 ) y —C(O)OR a , N—(CH 2 ) y —S(O) 2 R a , N—(CH 2 ) y —S(O) 2 OR a and N—(CH 2 ) y —C(O)NR c R c , with the proviso that Y and Z are not both simultaneously CH and CH 2 , respectively; and the chiral auxiliary group is wherein R 9 is hydrogen or (C1-C8) alkyl.