Patent ID: 6337021
Filing Date: 2002-01-08
Classification: G01N,Y02W

Abstract:
A method for separating a quantity of the (+) and (âˆ’) enantiomers of a racemic compound mixture from each other using high-speed countercurrent chromatography, comprising:(a) adding a chiral selector to a first liquid phase of two pre-equilibrated immiscible liquid phases and charging a countercurrent chromatographic centrifuge column with said first liquid phase, thereby producing a countercurrent chromatographic centrifuge column charged with said chiral selector and said first liquid phase; (b) introducing said racemic compound mixture into said countercurrent chromatographic centrifuge column thus charged with said chiral selector and said first liquid phase; and (c) passing a second liquid phase through said countercurrent chromatographic centrifuge column thus charged with said mixture, said chiral selector and said first liquid phase, to elute said (+) enantiomer and said (âˆ’) enantiomer from said countercurrent chromatographic centrifuge column, wherein said quantity is from 1 mg to 1 kg.