Patent ID: 6313176
Filing Date: 2001-11-06
Classification: A61K

Abstract:
A method for facilitating irreversible enzyme inhibition, when administering a therapeutically effective amount of medicament to a human, the method comprising the steps of:(a) selecting an irreversible enzyme inhibitor as a medicament that is metabolized into an unwanted or adversive metabolite that is increased by oral administration of the irreversible enzyme inhibitor, wherein the irreversible enzyme inhibitor is a deprenyl drug selected from the group consisting of levo-deprenyl, levo-desmethyl deprenyl, and combinations thereof;(b) placing the irreversible enzyme inhibitor in a suitable formulation selected from the group consisting of an intraoral administration formulation, an inhalation administration formulation, and combinations thereof;(c) administering a therapeutically effective amount of the formulation from step (b) so as to achieve irreversible enzyme binding in the brain of the human; and(d) utilizing this method over a period of one or more doses to achieve sustained high levels of the bound irreversible enzyme inhibitor relative to the unwanted metabolite with a dose that is lower than a dose needed to achieve the same high levels when administering the same irreversible enzyme inhibitor orally, whereby the lower dose results in a decrease in metabolization into the unwanted metabolite.