Patent ID: 8987419
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody or antigen-binding portion thereof comprising: a first amino acid sequence which is at least 90% identical to SEQ ID NO:2 or SEQ ID NO:3; and a second amino acid sequence which is at least 90% identical to SEQ ID NO:1, wherein the first amino acid sequence comprises at least three complementarity determining regions consisting of amino acids 31-35, 50-65, and 98-101 respectively of SEQ ID NO:2 or SEQ ID NO:3; wherein the second amino acid sequence comprises at least three complementarity determining regions consisting of amino acids 24-39, 55-61, and 94-102 respectively of SEQ ID NO:1; and wherein the antibody or antigen-binding portion thereof has a binding affinity to an Aβ(20-42) globulomer that is greater than the binding affinity of the antibody or antigen-binding portion thereof to an Aβ(1-42) globulomer.