Patent ID: 7641911
Filing Date: 2010-01-05
Classification: A61K,C07H

Abstract:
1. An oil-in-water adjuvant composition comprising water, a metabolizable oil comprising at least one branched or unbranched long-chain hydrocarbon moiety, a steroid, a saponin and a muramyl tripeptide, wherein said adjuvant composition is formed by a method comprising: (a) emulsifying a mixture comprising (i) water, (ii) a water-immiscible organic solvent, (iii) said metabolizable oil, (iv) said steroid, (v) said saponin and (vi) said muramyl tripeptide; and (b) removing the organic solvent from the emulsion that is formed in step (a), such that an oil-in-water emulsion is formed in which at least 80% by number of the oil droplets within the emulsion are less than 1 micron in diameter.