Patent ID: 6423713
Filing Date: 2002-07-23
Classification: A61P,C07D

Abstract:
A compound or a pharmaceutically-acceptable salt or tautomer thereof, wherein:the compound corresponds in structure to Formula IB: as to R1:R1 is selected from the group consisting of hydrido, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkylalene, cycloalkenylalkylene, haloalkyl, haloalkenyl, haloalkyhyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, aralkyl, aralkenyl, aralkynyl, carboxy, carboxyalkyl, alkoxyalkyl, alkenotyalkyl, alkynoxyalkyl, aryloxyalkyl, alkoxyalkoxy, mercaptoalkyl, alkylthioalkylene, alkenylthioalkylene, alkylthioalkenylene, amino, aminoalkyl, alkylamino, alkenylamino, alkynylamino, arylamino, alkylsulfinyl, alkenylsulfinyl, alkynylsulfinyl, arylsulfinyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, arylsulfonyl, alkylaminoalkylene, alkylsulfonylalkylene, acyl, acyloxycarbonyl, alkoxycarbonylalkylene, aryloxycarbonylalkylene, alkoxycarbonylarylene, aryloxycarbonylarylene, alkylcarbonylalkylene, arylcarbonylalkylene, alkylcarbonylarylene, arylcarbonylarylene, alkylcarbonyloxyalkylene, arylcarbonyloxyalkylene, alkylcarbonyloxyarylene, and arylcarbonyloxyarylene, or R1 has the formula: i is an integer from 0 to 9; and R25 is selected from the group consisting of hydrogen, alkyl, aralkyl, alkoxyalkylene, aryloxyalkylene, aminoalkyl, alkylaminoalkyl, arylaminoalkyl, alkylcarbonylalkylene, and arylcarbonylalkflene; and R26 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkylalkylene, aralkyl, alkoxycarbonylalkylene, and alkylaminoalkyl; and as to R27: R27 is selected from the group consisting of alkyl, cycloalkyl, alkynyl, aryl, aralkyl, cycloalkylalkylene, cycloalkenylalkylene, cycloalkylarylene, cycloalkylcycloalkyl, alkylarylene, alkylaralkyl, aralkylaylene, alkoxyalkylene, alkoxyarylene, alkoxyaralkyl, alkoxyaitoxyarylene, aryloxyarylene, aralkoxyarylene, aryloxyaitoxyarylene, alkoxycarbonylalkylene, aminoalkyl, alkylaminoalkylene, arylaminocarbonylalkylene, alkoxyarylaminocarbonylalkylene, aminocarbonylalkylene, arylaminocarbonylalkylene, alkylaminocarbonylalkylene, arylcarbonylalkylene, alkoxycarbonylarylene, aryloxyctrbonylarylene, alkylaryloxycarbonylarylene, arylcarbonylarylene, alkylarylcarbonylarylene, alkoxycarbonylalkoxylarylene, alkylthioalkylene, cycloalkylthioalkylene, alkylthioarylene, aralkylthioarllene, arylthioalklylarylene, arylsulfonylaminoaaylene, alkylsulfonylarylene, and alkylaminosulfonylarylene, wherein: the alkyl, cycloalkyl, aralkyl, alkoxyarylene, aryloxyarylene, arylaminocarbonylalkylene, aryloxycarbonylarylene, arylcarbonylarylene, alkylthioarylene, arylthioalklylarylene, or alkylsulfonylarylene may be optionally substituted with one or more radicals independently selected from the group consisting of alkyl, halo, haloalkyl, alkoxy, keto, amino, nito, and cyano, or R27 is â€”CHR28R29; and R28 is alkoxycarbonyl; and R29 is selected from the group consisting of aralkyl, aralkoxyalkylene, alkoxycarbonylalkylene, alkylthioalkylene, and aralkylthioalkylene, wherein: the aralkyl may be optionally substituted with one or more radicals independently selected from the group consisting of alkyl and nitro; and R2 is selected from the group consisting of piperidinyl and piperazinyl, where in: the piperidinyl or piperazinyl may be optionally substituted with one or more radicals independently selected from the group consisting of halo, keto, amino, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, aralkyl, heterocyclylalkyl, epoxyalkyl, amino(hydroxyalkyl) carboxy, alkoxy, aryloxy, aralkoxy, haloalkyl, alkylamino, alkynylamino, alkylaminoalkylamino, heterocyalylalkylamino, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, arylsulfonyl, and aralkylsulfonyl; and R3 is pyridinyl, wherein: the pyridinyl may be optionally substituted with one or more radicals independently selected from the group consisting of halo, alkyl, aralkyl, aralkenyl, carboxy, carboxyalkyl, alkoxy, aryloxy, alkylthio, arylthio, arylsulfinyl, arylsulfonyl, aralkoxy amino, alkylamino, alkenylamino, alkynylamino, cycloalkylamino, cycloalkenylamino, arylamino, aminocarbonyl, cyano, hydroxy, hydroxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkoxycarbonylamino, alkoxyaralkylamino, alkylaminoalkylamino, hydroxyalkylamino, aralkylamino, nitro, alkylaminocarbonyl, alkylcarbonylamino, halosulfonyl, aminoalkyl, haloalkyl, alkylcarbonyl, hydrazinyl, alkylhydrazinyl, arylhydrazinyl, and â€”NR44R45; and R44 is selected from the group consisting of alkylcarbonyl and amino; and R45 from the group consisting of alkyl and alkyl; and R4 is phenyl, wherein: the phenyl may be optionally substituted with one or more radicals independently selected from the group consisting of halo, alkyl, alenyl, alkynyl, aryl, alkylthio, arylthio, alkylthioalkylene, arylthioalkylene, alkylsulfmylalkylene, arylsulfinylalkylene, alkylsulfonylalkylene, arylsulfonylalkylene, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylarninocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, cyan, nitro, alkylamino, arylamino, alkylaminoalkylene, arylaminoalkylene, aminoalkylamino, and hydroxy.