Patent ID: 6200980
Filing Date: 2001-03-13
Classification: A61K,C07D

Abstract:
A method of treating a patient having precancerous lesions in need of treatment wherein the precancerous lesions are sensitive to a compound below, comprising administering to the patient a pharmacologically effective amount of a compound of the formula: ##STR25##whereinR.sup.1 is H; C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl substituted with one or more fluoro substituents; or C.sub.3 -C.sub.5 cycloalkyl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkyl substituted with one or more fluoro substituents or with C.sub.3 -C.sub.6 cycloalkyl;R.sub.3 is C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 alkyl substituted with one or more fluoro substituents or with C.sub.3 -C.sub.6 cycloalkyl; C.sub.3 -C.sub.5 cycloalkyl; C.sub.3 -C.sub.6 alkenyl; or C.sub.3 -C.sub.6 alkynyl;R.sub.4 is C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 alkyl substituted with OH, NR.sup.5 R.sup.6, CN, CONR.sup.5 R.sup.6, SO.sub.2 NR.sup.5 R.sup.6, or CO.sub.2 R.sup.7 ; C.sub.2 -C.sub.4 alkenyl; C.sub.2 -C.sub.4 alkenyl substituted with CN, CONR.sup.5 R.sup.6 or CO.sub.2 R.sup.7 ; C.sub.2 -C.sub.4 alkanoyl; C.sub.2 -C.sub.4 alkanoyl substituted with NR.sup.5 R.sup.6 ; hydroxy C.sub.2 -C.sub.4 alkyl; hydroxy C.sub.2 -C.sub.4 alkyl substituted with NR.sup.5 R.sup.6 ; (C.sub.2 -C.sub.3 alkoxy) C.sub.1 -C.sub.2 alkyl; (C.sub.2 -C.sub.3 alkoxy)C.sub.1 -C.sub.2 alkyl substituted with OH or NR.sup.5 R.sup.6 ; CH.dbd.CHCN; CH.dbd.CHCONR.sup.5 R.sup.6 ; CH.dbd.CHCO.sub.2 R.sup.7 ; CONR.sup.5 R.sup.6 ; CO.sub.2 R.sup.7 ; halo; NR.sup.5 R.sup.6 ; NHSO.sub.2 NR.sup.5 R.sup.6 ; NHSO.sub.2 R.sup.8 ; phenyl or phenyl substituted with methyl; or pyridyl or imidazolyl either of which is substituted with H or methyl;R.sup.5 and R.sup.6 are each independently H or C.sub.1 -C.sub.4 alkyl, or together with the nitrogen atom to which they are attached form a 4-(NR.sup.9)piperazinyl group wherein said group is substituted with H, C.sub.1 -C.sub.4 alkyl or hydroxy;R.sup.7 is H or C.sub.1 -C.sub.4 alkyl;R.sup.8 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkyl substituted with NR.sup.5 R.sup.6 ; andR.sup.9 is H; C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkyl substituted with phenyl; hydroxy C.sub.2 -C.sub.3 alkyl; or C.sub.1 -C.sub.4 alkanoyl or pharmaceutically acceptable salts thereof; andX.sup.1, X.sup.2 and X.sup.3 may be independently nitrogen or carbon with the proviso that: at least two of X.sup.1, X.sup.2 and X.sup.3 must be nitrogen.