Patent ID: 6291514
Filing Date: 2001-09-18
Classification: C07D

Abstract:
A compound of Formula I: ##STR40##or a solvate, hydrate or pharmaceutically-acceptable salt thereof, wherein:X is sulfur;Y is a covalent bond or NH;Z is NR.sup.5 R.sup.6 ;R.sup.1 is a hydrogen, amino, hydroxy or halogen;R.sup.2 isalkylsulfonylamino, aralkylsulfonylamino, aralkenylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, di(aralkylsulfonyl)amino, di(aralkenylsulfonyl)amino, di(arylsulfonyl)amino, or di(heteroarylsulfonyl)amino, wherein any of the aryl or heteroaryl containing groups are optionally substituted on the aromatic ring; oramino, monoalkylamino, dialkylamino, monoarylamino, diarylamino, monoalkylmonoarylamino, monoaralkylamino, diaralkylamino, monoalkylmonoaralkylamino, monoheterocycleamino, diheterocycleamino, monoalkylmonoheterocycleamino, wherein any of the aryl or heterocycle containing groups is optionally substituted; oralkanoylamino, alkenoylamino, alkynoylamino, aroylamino, aralkanoylamino, aralkenoylamino, heteroaroylamino, heteroarylalkanoylamino, any of which is optionally substituted on the aromatic ring; oralkoxycarbonylamino, aralkoxycarbonylamino, aryloxycarbonylamino,wherein any of the aryl containing groups is optionally substituted on the aromatic ring; orformylamino, H(S)CNH--, or thioacylamino;R.sup.3 is hydrogen, C.sub.1-6 alkylthio, C.sub.1-6 alkyl optionally substituted with OH, NH.sub.2, COOH, aminocarbonyl, or C.sub.1-6 alkoxy; andR.sup.4, R.sup.5 and R.sup.6 are independently hydrogen, C.sub.1-4 alkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C.sub.2-10)alkyl, dialkylamino(C.sub.2-10)alkyl, carboxyalkyl, cyano, amino, alkoxy, or hydroxy, or --CO.sub.2 R.sup.w, whereR.sup.w is alkyl, cycloalkyl, phenyl, benzyl, ##STR41##where R.sup.d and R.sup.e are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.f is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.g is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, and R.sup.h is aralkyl or C.sub.1-6 alkyl.