Patent ID: 6579873
Filing Date: 2003-06-17
Classification: C07D

Abstract:
A compound, a tautomer of the compound, or a pharmaceutically-acceptable salt of the compound or tautomer, wherein:the compound corresponds in structure to Formula I: â€ƒR1 is hydroxyalkyl; R2 is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, heterocyclyl, haloalkyl, heterocyclylalkelene, amino, alkylamino, aminoalkyl, alkoxy, alkylthio, carboxy, alkoxycarbonyl, carboxyalkyl, aminocarbonylamino, alkylamicarbonylamino, alkysulfonyl, aminosulfonyl, alkylsulfonylamino, amisosulfonylamino, alkylaminosulfonylamino, and alkynylamino, wherein: the heterocyclyl and heterocyclylalkelene are optionally substituted with one or more radicals independently selected from the group consisting of alkylthio, alkylsulfonyl, alkylsulfinyl, halo, alkyl, alkoxy, aryloxy, aralkoxy, heterocyclyl, haloalkyl, amino, cyano, and hydroxy; Ar1 is aryl optionally substituted with one or more radicals independently selected from the group consisting of halo, alkyl, alkenyl alkynyl, alkoxy, alkenoxy, alkyldioxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, aminocarbonyl, cyano, alkoxycarbonyl, formyl, aminosulfonyl, alkylamino, nitro, arylamino, arlkylcarbonylamino, halosulfonyl, aminoalkyl, and haloalkyl; HetAr2 is selected from the group consisting of pyridinyl, and quinolinyl, wherein: the pyridinyl, pyrimidinyl, and quinolinyl are optionally substituted with one or more radicals independently selected from the group consisting of alkylthio, alkylsulfonyl, alkylsulfinyl, halo, alkyl, heterocyclcyl, alkoxy, aralkoxy, haloalkyl, amino, cyano, aralkyl, alkylamino, cycloalkylamino, cycloalkenylamino, arylamino, alkynylamino, and aralkylamino; and if HetAr2 is pyridinyl, then R2 is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, haloalkyl, heterocyclylalkelene, aminoalkyl, alkoxy, alkylthio, carboxy, alkoxycarbonyl, carboxyalkyl, aminocarbonylamino, alkylaminocarbonylamino, alkylsulfonyl, aminosulfonyl, alkylsulfonylamino, aminosulfonylamino, alkylaminosulfonylamino, and alkynylamino, wherein: The heterocyclylalkelene is optionally substituted with one or more radicals independently selected from the group consisting of alkylthio, alkylsulfonyl, alkylsulfinyl, halo, alkyl, alkoxy, aryloxy, aralkoxy, heterocyclyl, haloalkyl, amino, cyano, and hydroxy.