Patent ID: 8198441
Filing Date: 2012-06-12
Classification: A61P,C07D

Abstract:
1. A process for preparing a mTOR kinase inhibitor of Formula 5: wherein: R R comprising: (i) reacting a compound of Formula 2a: wherein: R R R with 6-aminouracil, to give a compound of Formula 1 wherein: R (ii) reacting the compound of Formula 1 with a halogenating agent to give a compound of Formula 4: wherein: R X is a halogen; (iii) reacting the compound of Formula 4 with 3-methylmorpholine to give a compound of Formula 5; (iv) optionally converting the compound of Formula 5 to further compounds of Formula 5 by: (v) and optionally isolating the compound of formula 5 as a salt.