Patent ID: 8022076
Filing Date: 2011-09-20
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) wherein R1 is aryl, which is unsubstituted or substituted at any position with one, two, three, or four substituents selected from the group consisting of cyano, halogen, nitro, trifluoromethyl, alkyl, alkylthio, alkoxy, NR9R10, CO R2 is H; alkyl, which is unsubstituted or substituted at any position with one or two substituents selected from the group consisting of halogen, cyano, nitro, NR9R10, alkoxy, hydroxyl, unsubstituted aryl, unsubstituted heteroaryl, CO R3 is H; NR4R5; NHC(O)R8; halo; trifluoromethyl; alkyl, which is unsubstituted or substituted at any position with one or two substituents selected from the group consisting of halogen, cyano, nitro, NR9R10, alkoxy, hydroxyl, unsubstituted aryl, unsubstituted heteroaryl, CO R4 and R5 may be the same or different, and may be H; alkyl, which is unsubstituted or substituted at any position with one or two substituents selected from the group consisting of halogen, cyano, nitro, NR9R10, alkoxy, hydroxyl, unsubstituted aryl, unsubstituted heteroaryl, CO X is O, S or NR6; R6 is H or alkyl, which is unsubstituted or substituted at any position with one or two substituents selected from the group consisting of halogen, cyano, nitro, NR9R10, alkoxy, hydroxyl, unsubstituted aryl, unsubstituted heteroaryl, CO R7 is hydrogen, methyl or ethyl; R8 is methyl or ethyl; R9 and R10 are independently selected from the group consisting of hydrogen, unsubstituted alkyl, unsubstituted aryl, unsubstituted heteroaryl, unsubstituted cycloalkyl, aminoethyl, methylaminoethyl, hydroxyethyl, and alkoxyethyl; or R9 and R10 taken together form a saturated, unsaturated, or partially saturated 4 to 7 membered ring; L is (CH Y is heterocyclic group, which is unsubstituted or substituted at any position with a substituent selected from the group consisting of cyano, nitro, halogen, alkyl, alkylthio, alkoxy, NR9R10, CO or a pharmaceutically acceptable salt thereof; with the proviso that when Y is furanyl; tetrahydrofuranyl; pyrimidinyl; pyrrolidinyl or 1,3-benzodioxolyl, then R1 is not phenyl, phenyl monosubstituted by halogen or phenyl substituted by methyl; and wherein the compound is not: 5-Phenyl-N-(pyridin-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Chlorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]thieno[2,3-d]pyrimidin-4-amine; 5-(4-Chlorophenyl)-N-(pyridin-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Chlorophenyl)-N-(pyridin-3-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Fluorophenyl)-N-(pyridin-3-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; N-Allyl-5-phenylthieno[2,3-d]pyrimidin-4-amine; 5-(4-Methylphenyl)-N-(2-thien-2-ylethyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Chlorophenyl)-N-(2-thien-2-ylethyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Fluorophenyl)-N-(2-thien-2-ylethyl)thieno[2,3-d]pyrimidin-4-amine; N-Allyl-5-(4-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine; 5-(4-Bromophenyl)-N-(pyridin-3-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; N-[3-(1H-Imidazol-1-yl)propyl]-5-phenylthieno[2,3-d]pyrimidin-4-amine; or 1-(2-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl)imidazolidin-2-one.