Patent ID: 6022866
Filing Date: 2000-02-08
Classification: A61K

Abstract:
A method of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of a therapeutically effective non-toxic amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof, and a therapeutically effective amount of an agent selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID), Vitamin C, a stenosis inhibiting drug, an anti-oxidant, a free radical scavenger and combinations thereof for enhancing the effect of the form of hyaluronic acid administered in the inhibition of the narrowing of the tubular walls to the animal to inhibit the narrowing of the vascular tubular walls by the proliferation of the endothelial cells on the area of trauma, and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons and greater than 150,000 daltons.