Patent ID: 6759416
Filing Date: 2004-07-06
Classification: A61K,C07D

Abstract:
A compound of the following formula or a pharmaceutically acceptable salt thereof:Long chain unsaturated fatty acid-linker-CPTâ€ƒâ€ƒ(Formula I) wherein:the Long-chain unsaturated fatty acid is C12-C22 mono or poly unsaturated fatty acids; the linker is -(alkyl)m-(aryl)n-C(O)â€” or -(aryl)m-(alkyl)n-C(O)â€”; wherein: m and n are independently 0-3, and m+n&gE;1; and CPT is a camptothecin compound with the following general structure (Formula II): â€ƒwherein: R1-R5 are H, halo, OH, NO2, NH2, alkyl, O-alkyl, NH-alkyl, or N(alkyl)2.