Patent ID: 7939261
Filing Date: 2011-05-10
Classification: C12Q,G01N,G16B

Abstract:
1. A method for determining the likelihood of breast cancer recurrence or response to hormonal therapy in a human subject comprising: (a) measuring the expression levels of the RNA transcripts of SURV, Ki.67, MYBL2, CCNB1, STK15, CTSL2, and STMY3, or their expression products, in a biological sample containing tumor cells obtained from said subject; (b) calculating a recurrence score (RS) for said subject by weighting the measured expression levels of gene subsets by contribution to breast cancer recurrence, wherein the gene subsets comprise: and (c) creating a report providing the RS; wherein the RS is indicative of the likelihood of breast cancer recurrence in said subject or response of said subject to hormonal therapy.