Patent ID: 6288278
Filing Date: 2001-09-11
Classification: A61P,C07C

Abstract:
A 3-Amino-3-arylpropan-1-ol compound corresponding to formula I ##STR14##whereinR.sup.1 and R.sup.2 each independently denote C.sub.1-6 -alkyl, or R.sup.1 and R.sup.2 together form a (CH.sub.2).sub.2-6 ring, which can also be benzo-fused or phenyl-substituted;R.sup.3 denotes H or methyl;R.sup.4 and R.sup.5 each independently denote C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl, phenyl, benzyl or phenethyl, or R.sup.4 and R.sup.5 together form a (CH.sub.2).sub.3-6 or CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 ring;A denotes a substituted or unsubstituted aryl radical, which optionally contains heteroatoms in the ring system;X denotes a substituted benzyl group corresponding to formula XI ##STR15##or a substituted benzoyl group corresponding to formula XII ##STR16##whereinR.sup.12 to R.sup.14 each independently denote H, F, Cl, Br, CHF.sub.2, CF.sub.3, OR.sup.11, SR.sup.11, OCF.sub.3, SO.sub.2 CH.sub.3, SO.sub.2 CF.sub.3, C.sub.1-6 -alkyl, phenyl, CN, COOR.sup.11 or NO.sub.2, whereR.sup.11 denotes H, C.sub.1-6 -alkyl, phenyl, benzyl or phenethyl;and diastereomers or enantiomers thereof, or a salt thereof with a physiologically acceptable acid.