Patent ID: 7264816
Filing Date: 2007-09-04
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated virulent systemic calicivirus (VS-FCV), wherein said virus causes a highly contagious hemorrhagic fever syndrome in cats with symptoms selected from the group consisting of high fever, edema, ulceration, hair loss, nasal and ocular discharge, anorexia, depression, and death, wherein treatment of said cats with an immunologically effective dose of FCV-F9 achieves substantially no protection against infection with VS-FCV; and wherein said VS-FCV comprises a capsid protein including lysine at amino acid position 448; glutamic acid at amino acid position 452; and lysine or aspartic acid at amino acid position 581 when optimally aligned with the capsid protein of SEQ ID NO:1.