Patent ID: 6309854
Filing Date: 2001-10-30
Classification: A61K,A61P,C07K

Abstract:
# SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 21 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1970 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: AAAACATAAT GTGGGTCTCG CGTCTGCCTC TCTCCCGCCC CTAATTAGCA GC #TGCCTCCC 60 TCCATATTGT CCCAGGCCAG CGCTTCTTTT GTGCTCCCAG ATTCCTGGGT GC #AAGGTGGC 120 CTCATTAGTG CCCGGAGACC GCCCCATCTC CAGGGAGCAG ATAGACAGAC AA #GGGGGTGA 180 TCAGGGGCAC AGTGATCCAA CCCTGGCCTC TGAACGCCGC AGCGGCCATT CC #TTGGGCCC 240 AGCCTGGAGA CGGCCCCCCT GCAGCAGGCT AATCTTAGAC TTGCCTTTGT CT #GGCCTGGG 300 TGTGGACGCA ATGTGCCTGT CAATTCCCCG CCACCTCAGA GCACTATAAA CC #CCAGACCC 360 CTGGGAGTGG GTCACAATTG ACAGCCTCAA GGTTCCTGGC TTTTTGAACC AC #CACAGACA 420 TCTCCTTTCC CGGCTACCCC ACCCTGAGCG CCAGACACCA TGAACCTTCC TT #CCACAAAG 480 GTAAAGATCC AGGGATGGAG GGGTGACTCA GCCATCCCAG AGGAAGCAAA AA #GAGTGCTT 540 GCTCAGAGGG CTGGAAGAAA GGCCAAAGGT GTCTCCACTC TTGGTCTTTT CC #TGGGTGTG 600 CTCTGAGGCA GGAGCACCTG CCTTGGCTCA CATTGGGTTG GGTGCTGTTT TG #CTAAGAGC 660 CTGTGTTTGC TGAGCTCATA TGTGTCAGGT GCTCCGTTTG CACCTGTCAT CT #CTTGTCAT 720 CCTCCCAACA GCCTTGCAGA GTAGAAATTA TTTCTAGTAT ACCCAGTTTA CA #GGTAAGGG 780 AGCTGTGCCC TCTGAAAGGG CAGGAAACTG GTTCAAAGCA ACGGAGTTCA GT #CACTCCTG 840 CAAGGGGGCA GGCAGATGAG AGAGCATTCT GGAGTCTTGC TAGTTCCTGA TT #TCCATGTG 900 TTTCCCTGCT GTGGAGAGGA AGTTGGGGGG ACTCAGTAGG GCCCGGGTTT TT #CCCAAGTT 960 TACAACTTCT GCTGCAGACA GACACTCCTG TTTTCAGGTG GAGTGGCAAG TG #CCCTAGTG 1020 GTGGCAACAG TGGCCTAAGT CTCCAGAGAA AAGGGGGATT CACTCTGCCC AG #GGGGTCTC 1080 AAAAGGCTTC CTGTGGGAGA TGCTCTGCTG GGTCTTGAAG GAGGAGCAGG GA #AAGTAGGC 1140 CGATACCAGC AAGGGCGCAA AGCAAGGAGA ACTAAGTGAC AGCCAGAAAG GA #GTGCAGGC 1200 TTGGAGGGGG CGCGGAGCCA GAGGGGCAGG TCCTGTGCGT GGGAGCTGGT GG #CGGGCGCC 1260 GTGGGAAGAC CCCCCCAGCG CCCTGTCTCC GTCTCCCTAG GTCTCCTGGG CC #GCCGTGAC 1320 GCTACTGCTG CTGCTGCTGC TGCTGCCGCC CGCGCTGTTG TCGTCCGGGG CG #GCTGCACA 1380 GCCCCTGCCC GACTGCTGTC GTCAAAAGAC TTGCTCTTGC CGCCTCTACG AG #CTGCTGCA 1440 CGGCGCGGGC AATCACGCGG CCGGCATCCT CACGCTGGGC AAGCGGAGGT CC #GGGCCCCC 1500 GGGCCTCCAG GGTCGGCTGC AGCGCCTCCT GCAGGCCAGC GGCAACCACG CC #GCGGGCAT 1560 CCTGACCATG GGCCGCCGCG CAGGCGCAGA GCCAGCGCCG CGCCCCTGCC TC #GGGCGCCG 1620 CTGTTCCGCC CCGGCCGCCG CCTCCGTCGC GCCCGGAGGA CAGTCCGGGA TC #TGAGTCGT 1680 TCTTCGGGCC CTGTCCTGGC CCAGGCCTCT GCCCTCTGCC CACCCAGCGT CA #GCCCCCAG 1740 AAAAAAGGCA ATAAAGACGA GTCTCCATTC GTGTGACTGG TCTCTGTTCC TG #TGCGGTCG 1800 CGTCCTGCCC ATCCGGGGTG GCAAAGCGTC TTGCGGAGGA CAGCTGGGCC TG #GAAGCCCG 1860 GCTGTCGGGC ACCAGCCTTA GCTTTTGCGT GGTTGAATCG GAAACACTCT TG #GTTGGGGA 1920 GTTCCCAGTG CAAGGCCCTG GGGCACAGAG AGAACTGCAC AGGTGCATGC # 1970 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 131 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: Met Asn Leu Pro Ser Thr Lys Val Ser Trp Al #a Ala Val Thr Leu Leu 1 5 # 10 # 15 Leu Leu Leu Leu Leu Leu Pro Pro Ala Leu Le #u Ser Ser Gly Ala Ala 20 # 25 # 30 Ala Gln Pro Leu Pro Asp Cys Cys Arg Gln Ly #s Thr Cys Ser Cys Arg 35 # 40 # 45 Leu Tyr Glu Leu Leu His Gly Ala Gly Asn Hi #s Ala Ala Gly Ile Leu 50 # 55 # 60 Thr Leu Gly Lys Arg Arg Ser Gly Pro Pro Gl #y Leu Gln Gly Arg Leu 65 #70 #75 #80 Gln Arg Leu Leu Gln Ala Ser Gly Asn His Al #a Ala Gly Ile Leu Thr 85 # 90 # 95 Met Gly Arg Arg Ala Gly Ala Glu Pro Ala Pr #o Arg Pro Cys Leu Gly 100 # 105 # 110 Arg Arg Cys Ser Ala Pro Ala Ala Ala Ser Va #l Ala Pro Gly Gly Gln 115 # 120 # 125 Ser Gly Ile 130 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Th #r Cys Ser Cys Arg Leu 1 5 # 10 # 15 Tyr Glu Leu Leu His Gly Ala Gly Asn His Al #a Ala Gly Ile Leu Thr 20 # 25 # 30 Leu (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Le #u Gln Arg Leu Leu Gln 1 5 # 10 # 15 Ala Ser Gly Asn His Ala Ala Gly Ile Leu Th #r Met 20 # 25 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 585 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: GGCTCGGCGG CCTCAGACTC CTTGGGTATT TGGACCACTG CACCGAAGAT AC #CATCTCTC 60 CGGATTGCCT CTCCCTGAGC TCCAGACACC ATGAACCTTC CTTCTACAAA GG #TTCCCTGG 120 GCCGCCGTGA CGCTGCTGCT GCTGCTACTG CTGCCGCCGG CGCTGCTGTC GC #TTGGGGTG 180 GACGCGCAGC CTCTGCCCGA CTGCTGTCGC CAGAAGACGT GTTCCTGCCG TC #TCTACGAA 240 CTGTTGCACG GAGCTGGCAA CCACGCCGCG GGCATCCTCA CTCTGGGAAA GC #GGCGACCT 300 GGACCCCCAG GCCTCCAAGG ACGGCTGCAG CGCCTCCTTC AGGCCAACGG TA #ACCACGCA 360 GCTGGCATCC TGACCATGGG CCGCCGCGCA GGCGCAGAGC TAGAGCCATA TC #CCTGCCCT 420 GGTCGCCGCT GTCCGACTGC AACCGCCACC GCTTTAGCGC CCCGGGGCGG AT #CCAGAGTC 480 TGAACCCGTC TTCTATCCCT GTCCTAGTCC TAACTTTCCC CTCTCCTCGC CG #GTCCCTAG 540 GCAATAAAGA CGTTTCTCTG CTAAAAAAAA AAAAAAAAAA AAAAA # 585 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 130 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: Met Asn Leu Pro Ser Thr Lys Val Pro Trp Al #a Ala Val Thr Leu Leu 1 5 # 10 # 15 Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Se #r Leu Gly Val Asp Ala 20 # 25 # 30 Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Th #r Cys Ser Cys Arg Leu 35 # 40 # 45 Tyr Glu Leu Leu His Gly Ala Gly Asn His Al #a Ala Gly Ile Leu Thr 50 # 55 # 60 Leu Gly Lys Arg Arg Pro Gly Pro Pro Gly Le #u Gln Gly Arg Leu Gln 65 #70 #75 #80 Arg Leu Leu Gln Ala Asn Gly Asn His Ala Al #a Gly Ile Leu Thr Met 85 # 90 # 95 Gly Arg Arg Ala Gly Ala Glu Leu Glu Pro Ty #r Pro Cys Pro Gly Arg 100 # 105 # 110 Arg Cys Pro Thr Ala Thr Ala Thr Ala Leu Al #a Pro Arg Gly Gly Ser 115 # 120 # 125 Arg Val 130 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: Met Asn Leu Pro Ser Thr Lys Val Pro Trp Al #a Ala Val Thr Leu Leu 1 5 # 10 # 15 Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Se #r Leu Gly Val Asp Ala 20 # 25 # 30 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Th #r Cys Ser Cys Arg Leu 1 5 # 10 # 15 Tyr Glu Leu Leu His Gly Ala Gly Asn His Al #a Ala Gly Ile Leu Thr 20 # 25 # 30 Leu (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Le #u Gln Arg Leu Leu Gln 1 5 # 10 # 15 Ala Asn Gly Asn His Ala Ala Gly Ile Leu Th #r Met 20 # 25 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 123 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: Val Pro Trp Ala Ala Val Thr Leu Leu Leu Le #u Leu Leu Leu Pro Pro 1 5 # 10 # 15 Ala Leu Leu Ser Leu Gly Val Asp Ala Gln Pr #o Leu Pro Asp Cys Cys 20 # 25 # 30 Arg Gln Lys Thr Cys Ser Cys Arg Leu Tyr Gl #u Leu Leu His Gly Ala 35 # 40 # 45 Gly Asn His Ala Ala Gly Ile Leu Thr Leu Gl #y Lys Arg Arg Pro Gly 50 # 55 # 60 Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Le #u Leu Gln Ala Asn Gly 65 #70 #75 #80 Asn His Ala Ala Gly Ile Leu Thr Met Gly Ar #g Arg Ala Gly Ala Glu 85 # 90 # 95 Leu Glu Pro His Pro Cys Ser Gly Arg Gly Cy #s Pro Thr Val Thr Thr 100 # 105 # 110 Thr Ala Leu Ala Pro Arg Gly Gly Ser Gly Va #l 115 # 120 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Th #r Cys Ser Cys Arg Leu 1 5 # 10 # 15 Tyr Glu Leu Leu His Gly Ala Gly Asn His Al #a Ala Gly Ile Leu Thr 20 # 25 # 30 Leu (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 amino #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Le #u Gln Arg Leu Leu Gln 1 5 # 10 # 15 Ala Asn Gly Asn His Ala Ala Gly Ile Leu Th #r Met 20 # 25 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: CAACCNCTNC CNGACTGCTG # # # 20 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: ATNCCNGCNG CATGATT # # # 17 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: GTTGCCAGCT CCGTGCAACA GTTCGTAGAG ACGG # # 34 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: CGGCAGGAAC ACGTCTTCTG GCG # # 23 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: TCCTTGGGTA TTTGGACCAC TGCACCGAAG # # 30 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: ATACCATCTC TCCGGATTGC CTCTCCCTGA # # 30 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: CCTCTGAAGG TTCCAGAATC GATAGTAN # # 28 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: CCTCTGAAGG TTCCAGAATC GATAG # # 25 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 577 base #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: CACAATTGAC AGCCTCAAGG TTCCTGGCTT TTTGAACCAC CACAGACATC TC #CTTTCCCG 60 GCTACCCCAC CCTGAGCGCC AGACACCATG AACCTTCCTT CCACAAAGGT CT #CCTGGGCC 120 GCCGTGACGC TACTGCTGCT GCTGCTGCTG CTGCCGCCCG CGCTGTTGTC GT #CCGGGGCG 180 GCTGCACAGC CCCTGCCCGA CTGCTGTCGT CAAAAGACTT GCTCTTGCCG CC #TCTACGAG 240 CTGCTGCACG GCGCGGGCAA TCACGCGGCC GGCATCCTCA CGCTGGGCAA GC #GGAGGTCC 300 GGGCCCCCGG GCCTCCAGGG TCGGCTGCAG CGCCTCCTGC AGGCCAGCGG CA #ACCACGCC 360 GCGGGCATCC TGACCATGGG CCGCCGCGCA GGCGCAGAGC CAGCGCCGCG CC #CCTGCCTC 420 GGGCGCCGCT GTTCCGCCCC GGCCGCCGCC TCCGTCGCGC CCGGAGGACA GT #CCGGGATC 480 TGAGTCGTTC TTCGGGCCCT GTCCTGGCCC AGGCCTCTGC CCTCTGCCCA CC #CAGCGTCA 540 GCCCCCAGAA AAAAGGCAAT AAAGACGAGT CTCCATT # # 5771. An isolated polynucleotide comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence selected from the group consisting of: SEQ ID NO:2; SEQ ID NO:4; SEQ ID NO:6; SEQ ID NO:8; and SEQ ID NO:9.