Patent ID: 8263549
Filing Date: 2012-09-11
Classification: A61K,A61P,C07K

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of R B is selected from the group consisting of: R (I) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C G is selected from the group consisting of —OH, —NR R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C alternatively, R L is selected from the group consisting of —CH X is absent or is selected from the group consisting of: (i) O; (ii) S; (iii) NR (iv) O—NH; Y is absent or is selected from the group consisting of: (i) —C(═O)—, —C(═O)—NH—, —S(O) (ii) —C (iii) —C (iv) —C (v) —C Z is selected from the group consisting of hydrogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, and substituted cycloalkenyl; Or X, Y and Z are taken together to form wherein Z 1 and Z 2 are independently selected from the group consisting of: (i) hydrogen; (ii) aryl; (iii) substituted aryl; (iv) heteroaryl; (v) substituted heteroaryl; (vi) heterocyclic or substituted heterocyclic; (vii) —C (viii) substituted —C (ix) —C (x) substituted —C (xi) —C (xii) substituted —C (xiii) —V—R R (i) hydrogen; (ii) aryl; (iii) substituted aryl; (iv) heteroaryl; (v) substituted heteroaryl; (vi) heterocyclic or substituted heterocyclic; (vii) —C (viii) substituted —C (ix) —C (x) substituted —C (xi) —C (xii) substituted —C or Z j=0, 1, 2, 3, or 4; k=1, 2, or 3; and m=0, 1, or 2.