Patent ID: 6464732
Filing Date: 2002-10-15
Classification: A61K,A61Q

Abstract:
A multi-compartment device or kit for dyeing keratin fibers, comprising at least a first compartment and second compartment, wherein said first compartment contains at least one pyrazoline-4,5-dione of formula (I), below, or a cosmetically acceptable salt thereof, in which: R1 is chosen from: a hydrogen atom; linear and branched C1-C6 alkyl radicals optionally substituted with a radical chosen from â€”OH, â€”COOH, C1-C4 alkoxy, C1-C4 hydroxyalkyl, and C1-C4 dialkylamino; a radical wherein m is 1, 2, or 3; n is 1, 2, or 3; R3 is chosen from hydrogen and methyl; and R4 is chosen from methyl, hydroxyl, linear and branched C1-C5 alkoxy radicals, and linear and branched C1-C5 hydroxyalkyl radicals;a radical wherein p is 1 or 2, and R5 is chosen from substituted and unsubstituted phenyl radicals;a radical wherein q is 1 or 2, and R6 is chosen from thienyl, furyl, pyridyl, piperidyl, and phenyl radicals, said phenyl radicals being optionally substituted with a maximum of 2 groups chosen from methyl, trifluoromethyl, sulphonyl, and methoxy radicals;phenyl radicals which are optionally substituted with one to five groups chosen from: â€”COOH, â€”CH2COOH, â€”NO2, â€”OH, â€”SO3H, â€”CH2OH, â€”OCF3, â€”CF3, â€”SO2CH3, â€”SO2NH2, â€”SO2NHC2H5, â€”SO2NHCH2CH2OH, â€”CON(CH3)2, â€”CON(C2H5)2, â€”CH2N(CH3)2, â€”CH2N(C2H5)2, â€”NHCOCH3, â€”NHCOC2H5, halogen, linear and branched C1-C3 alkyl radicals, and a radical â€”Zâ€”R7, wherein Z is chosen from O and S, and R7 is chosen from a hydrogen atom and linear and branched C1-C3 alkyl radicals; benzyl radicals which are optionally substituted with a radical chosen from â€”COOH, â€”OCH3, and â€”SO3H; and pyridyl, pyrimidinyl, pyrazinyl, thiazinyl, benzothiazolyl, benzimidazolyl, thienyl, imidazolyl, thiazolyl, 1,2,4-triazolyl, indazolyl, indolyl, quinolyl, and isoquinolyl radicals; and R2 is chosen from: a hydrogen atom; linear and branched C1-C6 alkyl radicals optionally substituted with a group chosen from hydroxyl and C1-C4 alkoxy radicals; phenyl radicals which are optionally substituted with a radical chosen from halogens, nitro, and trifluoromethyl. phenyl radicals substituted with a maximum of 3 radicals chosen from C1-C4 alkyl, C1-C4 alkoxy, C1-C4 dialkylamino, and C1-C2 alkylthio; a radical in which r is 1, 2, or 3, and R8 is chosen from â€”SO3H, C1-C2 alkylthio, benzylthio, methoxycarbonyl, ethoxycarbonyl, and phenyl radicals, said phenyl radicals being optionally substituted with a radical chosen from halogens, C1-C3 alkyl, C1-C3 alkoxy, C1-C4 dialkylamino, and C1-C2 alkylthio;C1-C4 alkoxy radicals; phenoxy radicals optionally substituted with at least one halogen atom; and trifluoromethyl, acetamido, C1-C2 dialkylamino, carboxyl, methoxycarbonyl, ethoxycarbonyl, thienyl, furyl, pyridyl, and pyrazolyl radicals; it being understood that when R2 is chosen from alkyl and phenyl radicals, R2 can be linked to the carbon atom of the pyrazoline ring via a hetero atom chosen from O, N and S; and said second compartment contains at least one aromatic or heteroaromatic amine of formula (II), below, or a cosmetically acceptable salt thereof: in which:R9 is chosen from: 5- and 6-membered rings optionally containing a maximum of 3 identical or different hetero atoms chosen from oxygen, nitrogen, and sulphur; and sets of 2 and 3 rings, wherein each set of rings contains a maximum of 9 identical or different hetero atoms chosen for oxygen, nitrogen, and sulphur, and each ring is 5- or 6-membered and is fused or linked together via a group chosen from O, N, S, and linear and branched, saturated and unsaturated, polymethylene radicals comprising from 1 to 5 carbon atoms, said polymethylene radicals optionally containing, linked to or intercalated in the main chain, at least one group chosen from oxygen, sulphur, nitrogen, sulphoxide, sulphone, disulphide, amino, C1-C2 alkylamino, hydroxyl, quaternary ammonium, ureido, amide, and ester radicals, wherein said R9 rings and sets of rings are optionally substituted with a maximum of 7 substituents chosen from amino, hydroxyl, cyano, trifluoromethyl, linear and branched C1-C4 alkyl, C1-C4 alkoxy, C1-C4 mono- and dialkylamino, carboxyl, C1-C2 alkoxycarbonyl, sulphonyl, sulphonamido, acetamido, amido, mercapto, C1-C4 alkythio, nitro, C1-C2 alkylsulphone, C1-C4 hydroxyalkyl, and keto radicals, and Cl, Br, and F atoms, and wherein said at least one aromatic or heteroaromatic amine can react, without an oxidizing agent, with said at least one pyrazoline-4,5-dione to form a dye.