Patent ID: 8906682
Filing Date: 2014-12-09
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of treating leukemia in a human patient, the method comprising administering to the human patient a pharmaceutical composition comprising an anti-tumor effective amount of a population of human T cells, wherein the T cells comprise a nucleic acid sequence that encodes a chimeric antigen receptor (CAR), wherein the CAR comprises a CD19 antigen binding domain comprising the amino acid sequence of SEQ ID NO:20, a CD8α hinge domain, a CD8α transmembrane domain, a 4-1 BB costimulatory signaling region, and a CD3 zeta signaling domain comprising the amino acid sequence of SEQ ID NO:24, wherein the T cells are T cells of the human patient having leukemia.