Patent ID: 6037325
Filing Date: 2000-03-14
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of the formula ##STR33## wherein X and Y are independently O, S or N wherein N is optionally substituted with alkyl, alkenyl, alkynyl being linear or branched; a phenyl, phenylalkenyl or phenylalkyl optionally substituted with halogen, cyano, nitro, haloalkyl, amino, aminoalkyl, dialkylamino, alkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, carboxyl, carboalkoxy, alkylcarboxamide, arylcarboxamide, alkylthio or haloalkylthio groups being linear or branched; a heteroaryl, heteroarylalkyl or heteroarylalkenyl wherein the heteroaryl group is a monocyclic five or six membered ring containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally substituted with halogen, cyano, nitro, haloalkyl, amino, aminoalkyl, dialkylamino, alkyl, alkoxy, alkenyl, alkynyl, haloalkoxy, carboxyl, carboalkoxy, alkylcarboxamide, arylcarboxamide, alkylthio or haloalkylthio groups being linear or branched,provided at least one of X or Y is N;provided that where both X and Y are N, only one of X or Y is substituted;R.sub.1 is alkyl, alkenyl, haloalkenyl, alkynyl being linear or branched; a phenyl, phenylalkenyl or phenylalkyl optionally substituted with halogen, cyano, nitro, haloalkyl, amino, aminoalkyl, dialkylamino, alkyl, alkenyl, aLkynyl, alkoxy, haloalkoxy, carboxyl, carboalkoxy, alkylcarboxamide, arylcarboxamide, alkylthio or haloalkylthio being linear or branched; or a heteroaryl, heteroarylalkyl or heteroarylalkenyl wherein the heteroaryl group is a monocyclic five or six membered ring containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally substituted with halogen, cyano, nitro, haloalkyl, amino, aminoalkyl, dialkylamino, alkyl, alkoxy, alkenyl, alkynyl, haloalkoxy, carboxyl, carboalkoxy, alkylcarboxatnide, arylcarboxamide, alkylthio or haloalkylthio being linear or branched;R.sub.2 is a linear or branched alkyl, alkylthio, alkylthioalkyl, cycloalkyl, alkylcycloalkyl, phenyl or a phenylalkyl optionally substituted with halogen, cyano, nitro, hydroxyl, haloalkyl, alkylthio, terminal guanidine, guanidine, alkyl guanidine, dialkyl guanidine or amidine;G is N or C optionally substituted with H, alkyl, cycloalkyl, aryl, heteroaryl or alkylheteroaryl;J.sub.1 and J.sub.2 are independently selected from H, alkyl, cycloalkyl, aryl, heteroaryl, alkylaryl and alkylheteroaryl; andJ.sub.3 is H, alkylacyl, arylacyl, arylalkylacyl, alkyl-SO.sub.2 --, aryl-SO2--, alkylaryl-SO.sub.2 --, heterocycle-SO.sub.2 --, alkyl-NH--SO.sub.2 --, aryl-NH--SO.sub.2 --, alkylaryl-NH--SO.sub.2 or heterocycle-NH--SO.sub.2 --;or a pharmaceutically acceptable salt thereof.