Patent ID: 6342636
Filing Date: 2002-01-29
Classification: C07B,C07C

Abstract:
A process for preparing an optically active 1-arylalkylamine, comprising the steps of:combining a racemic 1-arylalkylamine expressed by the formula Ia: â€ƒwherein, R1 is a hydrogen atom, a C1-C5 straight or branched chain alkyl or alkyloxy group, or phenyl group, wherein the phenyl group is optically substituted with one or more of a C1-C5 straight or branched chain alkyl or alkyloxy group, chlorine atom, bromine atom, iodine atom or nitro group; Ar is a group of one of the following formulas: â€ƒwherein R3 is a C1-C5 straight or branched chain alkyl or alkyloxy group, chlorine atom, bromine atom, iodine atom or nitro group and n is zero, one or two; with an optically active 1-naphthylglycolic acid or 2-naphthylglycolic acid, or one of their derivatives expressed by formula II below: â€ƒwherein R2 is one or more of a C1-C5 straight or branched chain alkyl or alkyloxy group, chlorine atom, bromine atom, iodine atom, or nitro group; and thendecomposing a diastereomer salt thus obtained to isolate an optically active 1-arylalkylamine.