Patent ID: 6692734
Filing Date: 2004-02-17
Classification: A61K,A61P,C07F

Abstract:
A composition for use in tumor treatment, comprising:a polymer-platinum complex designed to accumulate at a tumor site and composed of an N-alkyl acrylamide copolymer of the form: where m=0 and n=100 or where the ratio of m:n is 0.1-99.9, where R1 is H or CH3, R2 is a lower alkyl or lower hydroxyalkyl group, and R3 is an oligopeptide side chain spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of an oligopeptide attached at one end to the polymer and at the other end, at least primarily via a N,O-amidomalonate complex, to the platinum compound and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield a platinum compound which has, or is converted in vivo to have, anti-tumor activity.