Patent ID: 6878710
Filing Date: 2005-04-12
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: rings P—M are substituted with 0-1 R one of P G G is a group of formula IIa or IIb: ring D, including the two atoms of ring E to which it is attached, is a 5-6 membered non-aromatic ring consisting of carbon atoms, 0-1 double bonds, and 0-2 heteroatoms selected from the group consisting of N, O and S(O) alternatively, ring D, including the two atoms of ring E to which it is attached, is a 5-6 membered aromatic group consisting of carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O and S(O) E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 0-1 R alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, thiazolyl, thienyl and trizaolyl, and ring E is substituted with 0-2 R R alternatively, two R alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, and thienyl, and ring E is substituted with 1 R and with a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O) alternatively, ring D is absent and ring E is selected from pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thiophenyl, and thiazolyl, and ring E is substituted with R R A is selected from: B is selected from: Y, X—Y, (CH X is selected from —(CR Y is selected from: provided that X—Y do not form a N—N, O—N, or S—N bond; Z is selected from a bond, —(CR Z R is selected from H, C R R alternatively, when two R R R R R alternatively, R R R R R R R R R R R R R R R R R alternatively, R R n, at each occurrence, is selected from 0, 1, 2, and 3; p, at each occurrence, is selected from 0, 1, and 2; r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5 and 6; t, at each occurrence, is selected from 0, 1, 2, and 3; and provided that: alternatively, when alternatively, when