Patent ID: 8629122
Filing Date: 2014-01-14
Classification: A61L,A61P

Abstract:
1. A method of regenerating nucleus pulposus in an area where normal nucleus pulposus is to be present in a deformed intervertebral disc in an animal, the method comprising administering a nucleus pulposus filler comprising a photocrosslinked chondroitin sulfate as an active ingredient for regeneration, whereby the nucleus pulposus is regenerated; wherein the photocrosslinked chondroitin sulfate is obtained by: freezing a chondroitin sulfate to which a cinnamic acid or substituted cinnamic acid bound to a spacer is bound to through the spacer-containing solution comprising: the chondroitin sulfate to which the cinnamic acid or substituted cinnamic acid bound to a spacer is bound to through the spacer; an aqueous solvent capable of dissolving the chondroitin sulfate to which the cinnamic acid or substituted cinnamic acid bound to a spacer is bound to through the spacer; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a chelating agent; irradiating the resulting frozen product with light; and then melting the frozen product, and wherein the photocrosslinked chondroitin sulfate has the following properties: viscosity measured under conditions of 20° C. and standard corn (1 degree) by means of a rotary viscosimeter is from 300 to 30,000 mPa·S and the chondroitin sulfate has a gel form; and the nucleus pulposus filler is administered by injection.