Patent ID: 6710081
Filing Date: 2004-03-23
Classification: A61K,A61P,B82Y

Abstract:
A method for treatment of erectile dysfunction comprising administering to a subject in need of treatment an effective amount of one or more compounds selected from prostaglandin derivatives of formula (I) (wherein R1 represents a hydroxy, C1-6 alkyloxy or NR6R7 group (where R6 and R7 independently represent hydrogen or C1-4-alkyl),R2 represents an oxo, halogen, or Oâ€”COR8 group (where R8 represents C1-4-alkyl, phenyl or phenyl(C1-4-alkyl)), R3 represents hydrogen or hydroxy, R4a and R4b independently represent hydrogen or C1-4-alkyl, R5 represents a phenyl group substituted by the following group or groups: i) one to three of C1-4-alkyloxy-C1-4-alkyl, C2-4-alkenyloxy-C1-4-alkyl, C2-4-alkynyloxy-C1-4-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl(C1-4-alkyloxy)-C1-4-alkyl, phenyloxy-C1-4-alkyl, phenyl-C1-4-alkyloxy-C1-4-alkyl, C1-4-alkylthio-C1-4-alkyl, C2-4-alkenylthio-C1-4-alkyl, C2-4-alkynylthio-C1-4-alkyl, C3-7-cycloalkylthio-C1-4-alkyl, C3-7-cycloalkyl(C1-4-alkylthio)-C1-4-alkyl phenylthio-C1-4-alkyl, or phenyl-C1-4-alkylthio-C1-4-alkyl, ii) C1-4-alkyloxy-C1-4-alkyl and C1-4-alkyl, C1-4-alkyloxy-C1-4-alkyl and C1-4-alkyloxy, C1-4-alkyloxy-C1-4-alkyl and hydroxy, C1-4-alkyloxy-C1-4-alkyl and halogen, C1-4-alkylthio-C1-4-alkyl and C1-4-alkyl, C1-4-alkylthio-C1-4-alkyl and C1-4-alkyloxy, C1-4-alkylthio-C1-4-alkyl and hydroxy, or C1-4-alkylthio-C1-4-alkyl and halogen, iii) haloalkyl, or hydroxy-C1-4-alkyl, or iv) C1-4-alkyl and hydroxy;  represents a single bond or double bond, provided that when R2 is an Oâ€”COR8 group, the 8-9 positions represent a double bond), nontoxic salts thereof, or cyclodextrin clathrate compounds thereof.