Patent ID: 6011174
Filing Date: 2000-01-04
Classification: C07C,C07D

Abstract:
A compound of the formula (I), or its pharmaceutically acceptable salt or ester: ##STR113## wherein ##STR114## is an aryl group or a heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower alkenyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group, a lower alkoxy group, an aryl group and a heteroaromatic ring group; ##STR115## is a group of the formula ##STR116## when Q.sup.2 is a single bond, or a group of the formula ##STR117## when Q.sup.2 is a group of the formula --(CH.sub.2).sub.m -- or --(CH.sub.2).sub.n --W--(CH.sub.2).sub.p --; each of ##STR118## which are the same or different, is an aryl group or a heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a lower alkylamino group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower alkenyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group, a lower alkoxy group and an aralkyloxy group; ##STR119## is an aryl group, a heteroaromatic ring group or an aliphatic ring group which may contain one or two oxygen atoms, which may have substituent(s) selected from the group consisting of a halogen atom, a hydroxyl group, an oxo group, an amino group, a nitro group, a cyano group, a carboxyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower carbamoyloxyalkyl group, a lower alkylcarbamoyloxyalkyl group, a lower alkyl group, a lower fluoroalkyl group, a lower hydroxyalkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a sulfo group, a lower alkoxysulfonyl group, a sulfamoyl group, a lower alkylsulfamoyl group, an aryl group, a heteroaromatic ring group and a group of the formula --PO(OR.sup.4)(OR.sup.5); A.sup.1 is a C.sub.1-4 chain hydrocarbon group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group, a hydroxyl group, a lower hydroxyalkyl group and a lower alkoxy group; m is an integer of from 1 to 6; each of n and p which are the same or different, is an integer of from 0 to 3; Q.sup.1 is a single bond, a group of the formula --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 S-- or --SCH.sub.2 --, or a C.sub.1-6 chain hydrocarbon group which may have substituent(s) selected from the group consisting of a halogen atom and a lower alkyl group; Q.sup.2 is a single bond, or a group of the formula --(CH.sub.2).sub.m -- or --(CH.sub.2).sub.n --W--(CH.sub.2).sub.p --; Q.sup.3 is a single bond, an oxygen atom, a sulfur atom, a methylene group, a vinylene group, or a group of the formula --CO--, --NH--, --COO--, --OCO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --CH.sub.2 O--, --CH.sub.2 S--, --NHCO-- or --CONH--; R.sup.1 is a lower alkyl group; each of R.sup.2 and R.sup.3 which are the same or different, is a hydrogen atom, a hydroxyl group or a lower alkyl group; each of R.sup.4 and R.sup.5 which are the same or different, is a hydrogen atom or a lower alkyl group; W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; x is an integer of from 0 to 2; and y is 0 or 1.