Patent ID: 6329395
Filing Date: 2001-12-11
Classification: C07C,C07D

Abstract:
A compound having the structural formula ##STR415##or a pharmaceutically acceptable salt thereof, whereina and b are independently 0, 1 or 2, provided that the sum of a and b is 0 to 3;Q is ##STR416##X is --S--, --C(O)--, --CH(OR.sup.8)-- or --C(R.sup.23).sub.2 --;R.sup.1 is --N(C.sub.1 -C.sub.6 alkyl)(R.sup.12);R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently selected from the group consisting of H, C.sub.1 -C.sub.5 straight or branched alkyl, (C.sub.3 -C.sub.12)cycloalkyl, R.sup.14 --(C.sub.3 -C.sub.12)cycloalkyl, halogen, --OR.sup.8, --N(R.sup.8).sub.2, --CO.sub.2 R.sup.8 and CF.sub.3 ;R.sup.6 and R.sup.7 are independently selected from the group consisting of H, (C.sub.1 -C.sub.9)alkyl, (C.sub.1 -C.sub.9)alkenyl, hydroxy-(C.sub.1 -C.sub.9)alkyl, amino-(C.sub.1 -C.sub.9)-alkyl, (C.sub.1 -C.sub.9)alkoxy-(C.sub.1 -C.sub.9)alkyl, (C.sub.3 -C.sub.12)cycloalkyl and (C.sub.3 -C.sub.12)-cycloalkyl-(C.sub.1 -C.sub.6)alkyl, or R.sup.6 and R.sup.7, together with the carbon to which they are attached, form a 3, 4, 5, 6 or 7-membered carbocyclic ring, or a 4, 5, 6 or 7-membered heterocyclic ring, wherein 1, 2 or 3 ring members are independently selected from the group consisting of O, S and N;R.sup.8 is independently selected from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, R.sup.15 -aryl and R.sup.24 -heteroaryl;R.sup.9 is (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, R.sup.15 -aryl or R.sup.24 -heteroaryl;R.sup.12 is ##STR417##wherein q is 1 or 2, and s is 0, 1 or 2;R.sup.13 is 1 to 3 substituents independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, halogen, (C.sub.1 -C.sub.6)alkoxy and CF.sub.3;R.sup.14 is 1 to 3 substituents independently selected from the group consisting of (C.sub.1 -C.sub.6)alkyl, benzyl, R.sup.13 -aryl and R.sup.13 -heteroaryl;R.sup.15 is 1 to 3 substituents independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, halo, polyhalo(C.sub.1 -C.sub.6)alkyl, R.sup.17 O--, --N(R.sup.17).sub.2, --S(R.sup.17), R.sup.17 O--(C.sub.1 -C.sub.6)alkyl, (R.sup.17).sub.2 N--(C.sub.1 -C.sub.6)alkyl, formyl, --C(O)R.sup.17, --COOR.sup.17, --CON(R.sup.17).sub.2, --OC(O)N(R.sup.17).sub.2, --N(R.sup.17)C(O)N(R.sup.17).sub.2, --NR.sup.17 C(O)R.sup.17, --NR.sup.17 C(O)OR.sup.14, R.sup.17 S(O)--, R.sup.17 SO.sub.2 --, R.sup.17 SO.sub.2 NR.sup.17 -- and tri(C.sub.1 -C.sub.6)-alkylsilyl;R.sup.17 is independently selected from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, (C.sub.3 -C.sub.12)cycloalkyl(C.sub.1 -C.sub.6)alkyl, R.sup.13 -aryl and R.sup.13 -heteroaryl;R.sup.18 is independently selected from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, (C.sub.3 -C.sub.12)cycloalkyl-(C.sub.1 -C.sub.6)alkyl, R.sup.15 -aryl, R.sup.24 -heteroaryl, --CO.sub.2 R.sup.9, --C(O)N(R.sup.8).sub.2, --COR.sup.8 and --SO.sub.2 R.sup.9 ;R.sup.20 is (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, (C.sub.3 -C.sub.12)cycloalkyl-(C.sub.1 -C.sub.6)alkyl, hydroxy(C.sub.1 -C.sub.6)alkyl, oxo(C.sub.1 -C.sub.6)alkyl or polyhalo(C.sub.1 -C.sub.6)alkyl;R.sup.23 is independently selected from the group consisting of H, halogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.12)cycloalkyl, R.sup.15 -aryl, and R.sup.24 -heteroaryl; andR.sup.24 is 1 to 2 substituents independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, halo, polyhalo(C.sub.1 -C.sub.6)alkyl, R.sup.17 O--, --N(R.sup.17).sub.2, --S(R.sup.17), R.sup.17 O--(C.sub.1 -C.sub.6)alkyl, (R.sup.17).sub.2 N--(C.sub.1 -C.sub.6)alkyl, formyl, --C(O)R.sup.17, --COOR.sup.17, --CON(R.sup.17).sub.2, --OC(O)N(R.sup.17).sub.2, --N(R.sup.17)C(O)N(R.sup.17).sub.2, --NR.sup.17 C(O)R.sup.17, --NR.sup.17 C(O)OR.sup.14, R.sup.17 S(O)--, R.sup.17 SO.sub.2 --, R.sup.17 SO.sub.2 NR.sup.17 -- and tri(C.sub.1 -C.sub.6)-alkylsilyl.