Patent ID: 6388060
Filing Date: 2002-05-14
Classification: C08B

Abstract:
A process for sulfating a uronic acid-containing polysaccharide, said process comprising:a) conversion of said uronic acid-containing polysaccharide to an amine salt of said uronic acid-containing polysaccharide; b) treating said amine salt of said uronic acid-containing polysaccharide, dissolved in an aprotic solvent, with sulfuric acid to form a first solution and addition of N,Nâ€² carbodiimide to said first solution to form a second solution; c) adjusting the pH of said second solution to a pH above 12 for a period of time ranging from about 30 minutes to about 60 minutes and, thereafter, adjusting the pH of said second solution to a pH of about 7; and d) contacting said second solution with a sulfating agent to form said sulfated uronic acid-containing polysaccharide.