Patent ID: 6239151
Filing Date: 2001-05-29
Classification: A61P,C07C,C07D

Abstract:
A hydrazine compound, being a compound of the formula ##STR8##whereinR.sup.1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl;R.sup.2 is an acyl group derived from an .alpha.-, .beta.-, .gamma.- or .delta.-(arnino, hydroxy or thiol)-carboxylic acid, or an acyl group derived from an .alpha.-, .beta.-, .gamma.- or .delta.-(amino, hydroxy or thiol)carboxylic acid in which the amino, hydroxy or thiol group is lower alkylated or the amino group is acylated, sulphonylated or amidated, wherein any functional group present in a side-chain is protected or unprotected; or Het(CH.sub.2).sub.m CO--;R.sup.3 is hydrogen, lower alkyl, halo-lower alkyl, cyano-lower alkyl, amino-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, heterocyclyl-lower alkyl, heterocyclylcarbonyl-lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl-lower alkenyl, aryl or heterocyclyl;R.sup.4 is lower cycloalky or lower cycloalkyl-lower alkyl,Het is heterocyclyl; andm is 0,1,2,3 or 4;wherein each heterocyclyl or heteroaryl group is independently unsubstituted or substituted by halogen, lower alkyl, lower alkoxy, oxo, thioxo, or imino;or a mixture containing said compound and one or more optical isomers thereof, or a pharmaceutically acceptable salt of said compound or said mixture.