Patent ID: 8974787
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating or alleviating one or more symptoms of an inflammatory bowel disorder in a human subject, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof that immunospecifically binds to human LIGHT (hLIGHT), wherein hLIGHT activity is inhibited by the antibody or antigen-binding fragment, and wherein the antibody or antigen-binding fragment thereof comprises: a variable heavy (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of GYNWH (SEQ ID NO:20); a VH CDR2 comprising the amino acid amino acid sequence of EITHSGSTNYNPSLKS (SEQ ID NO:21); and a VH CDR3 comprising the amino acid sequence of EIAVAGTGYYGMDV (SEQ ID NO:22): and a variable light (VL) CDR1 comprising the amino acid sequence of RASQGINSAFA (SEQ ID NO:35); a VL CDR2 comprising the amino acid sequence of DASSLES (SEQ ID NO:36); and a VL CDR3 comprising the amino acid sequence of QQFNSYPLT (SEQ ID NO:37).