Patent ID: 6251901
Filing Date: 2001-06-26
Classification: A61K

Abstract:
A method to treat a condition in a vertebrate animal characterized by a deficiency in, or need for, bone growth replacement and/or an undesirable level of bone resorption, which method comprises administering to a vertebrate subject in need of such treatment an effective amount of a compound of the formula: ##STR6##wherein Ar.sup.1 has the following structure: ##STR7##where R.sup.1 is a non-interfering substituent;m is an integer of 0-4;each dotted line represents an optional .pi.-bond;each Z is independently N, NR, CR or CR.sub.2, where each R is independently H or alkyl (1-6C) with the proviso that at least one Z is N or NR; and whereinL is a flexible linker; andAr.sup.2 is a phenyl, naphthyl, an aromatic system containing a 6-membered ring or an aromatic system containing a 5-membered ring, all of which may be substituted or unsubstituted.