Patent ID: 6339083
Filing Date: 2002-01-15
Classification: A61P,C07D

Abstract:
A compound of the formula (I): whereR1 and R2 together with the formal double bond bridging them form a phenyl ring or a six-membered aromatic heterocycle having 1 or 2 nitrogen atoms, which is optionally substituted by halogen, nitro, cyano, trifluoromethyl, hydroxyl, (C1-C6)-alkyl, alkoxy, alkoxycarbonyl, amino, carboxyl, phenoxy, aryl, alkylamino, sulfone and sulfonamine, and R3=H or (C1-C4)-alkyl, and A=O, S, (CH2)n where n=1,2,3 or 4 or Nâ€”R7 where R7=H or (C1-C4)-alkyl, or is absent and X, Y, Z=O, S, N, Nâ€”R8 where R8=H, (C1-C6)-alkyl or aryl, or Câ€”(R9)(R10) where R9, R10=H, (C1-C6)-alkyl or aryl, or Câ€”(R11) if the X, Y or Z in question is participating in a formal double bond, where R11=H, (C1-C6)-alkyl or aryl, and D=O, S, (CH2)n where n=1,2,3 or 4, or Nâ€”R7 where R7=H or (C1-C4)-alkyl, or is absent and E, G, L=H, halogen, nitro, cyano, trifluoromethyl, hydroxyl, carboxyl, (C1-C6)-alkyl, alkoxy or alkoxycarbonyl, where E, G and L can be identical or different and R4=H, (C3-C8)-cycloalkyl, (C1-C6)-alkyl, which is optionally substituted by hydroxyl, (C1-C6)-alkoxy or phenyl, where the latter is optionally in turn substituted on the phenyl ring by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, hydroxyl, trifluoromethoxy or trifluoromethyl, and R5=H or (C1-C4)-alkyl and R6=H, (C1-C6)-alkyl or benzyl.