Patent ID: 6608089
Filing Date: 2003-08-19
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula (I):Zâ€”OCH2â€”Câ‰¡CCH2â€”NRR1â€ƒâ€ƒ(I) or a pharmaceutically acceptable salt or solvate thereof whereinR and R1 are the same or different and each represents a C1-6 alkyl, a carbocyclic group containing from 5 to 10 ring atoms or two rings with each ring containing 5 or 6 ring atoms, or R and R1 taken together with the nitrogen atom to which they are attached form a four- to eight-membered heterocyclic ring which may contain one or more additional heteroatoms selected from N, O or S, said heterocyclic ring being optionally substituted with a C1-4 alkyl group or a benzyl group; Z represents: wherein R2 and R3 are each independently selected from: (i) hydrogen; (ii) a substituted or unsubstituted, aromatic or non-aromatic carbocyclic or heterocyclic group containing from 5 to 10 ring atoms or two rings with each ring containing 5 or 6 ring atoms, wherein the heterocyclic group comprises a heteroatom selected from N, O and S, and wherein the carbocyclic or heterocyclic group can be substituted with one or more substituents being independently selected from the group consisting of: (a) Cl, (b) Br, (c) F, (d) OH, (e) NO2, (f) CF3, (g) C1-4 alkyl, (h) SCH3, (i) NHCOCH3, (j) N(R6)(R8) wherein R6 and R8, are the same or different and each represents H or a C1-4 alkyl, (k) OR10 wherein R10 represents H or C1-6 alkyl which may be saturated or unsaturated and may be unsubstituted or substituted with the group NRR1 wherein R and R1 is as defined above, and (1) OCOR11 wherein R11 represents H or C1-4 alkyl, (iii) Cl; (iv) Br; (v) F; (vi) OH; (vii) NO2; (viii) a saturated or unsaturated C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted with from 1 to 3 substituents selected from Cl, Br, F, OMe, NO2 and CF3; (ix) NHCOCH3; (x) N(R6)(R8), wherein R6 and R8 are defined above; (xi) SR10, wherein R10 is defined above; (xii) OR10 wherein R10 is defined above; and (xiii) OCOR11 wherein R11 is defined above; or R2 and R3 taken together with the carbon atoms to which they are attached form a saturated or unsaturated carbocyclic or heterocyclic ring having 5 or 6 ring atoms, wherein the heterocyclic group comprises a heteroatom selected from N, O and S, and wherein the carbocyclic or heterocyclic group can be substituted with one or more substituents being independently selected from the group consisting of Cl, Br, F, OH, NO2, CF3, C1-4 alkyl, SCH3, NHCOCH3, N(R6)(R8), OR10 and OCOR11 wherein R6, R8, R10 and R11 are as defined above; and R4 represents hydrogen, or OR10 wherein R10 is as defined above; or wherein R5 hydrogen or a C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted with from 1 to 3 substituents selected from Cl, Br, F, OMe, NO2 and CF3; with the proviso that when Z represents and R5 is hydrogen or an alkyl group containing up to 4 carbon atoms then R and R1 cannot be an alkyl groups that contains from 1 to 4 carbon atoms or R and R1 when taken together with the nitrogen atom to which they are attached cannot form a saturated heterocyclic amino radical containing 5 to 7 ring members.