Patent ID: 6750244
Filing Date: 2004-06-15
Classification: A61K,C07B,C07C,C07D

Abstract:
A compound of Formula VIII: wherein:Z is selected from the group consisting of: â€”Sâ€”CH2â€”, â€”Oâ€”CH2â€”, â€”Oâ€”, and â€”Sâ€”; X1 and X2 are independently selected from the group consisting of F, â€”Cl, â€”CH3, â€”OH, and lower O-alkyl in the 1-, 3-, 7-, or 9-substituent positions; m is independently an integer from 0 to 2, provided that at least one of m is not 0; â€”NHR is selected from the group consisting of â€”NH2, â€”NHCH3, and â€”NHC2H5; R1 is selected from the group consisting of â€”H, alkyl, hydroxyalkyl, â€”OH, â€”O-alkyl, and â€”O-acyl, and R2 is selected from the group consisting of â€”H, alkyl, hydroxyalkyl, and pharmaceutically acceptable salts and complexes thereof, wherein the compound is active at an NMDA receptor.