Patent ID: 8084611
Filing Date: 2011-12-27
Classification: A61P,C07D

Abstract:
1. A process for preparing (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-4-ylamine shown in the formula I-a: or a salt thereof, comprising catalytic reduction of (R)-2-ethyl-6-trifluoromethyl-2,3-dihydro-1H-quinolin-4-one oxime or (R)-2-ethyl-6-trifluoromethyl-2,3-dihydro-1H-quinolin-4-one O-alkyl-oxime in the presence of a palladium catalyst, followed by conversion of the product into a salt thereof, if desired.