Patent ID: 8637018
Filing Date: 2014-01-28
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical composition comprising a pharmaceutical carrier and a humanized anti-interleukin-18 antibody; said humanized anti-interleukin-18 antibody comprising a heavy chain and light chain comprising the following complementarity determining regions: a CDRH1 with the amino acid sequence shown in SEQ ID NO:1; a CDRH2 with the amino acid sequence shown in SEQ ID NO:2; a CDRH3 with the amino acid sequence shown in SEQ ID NO:3; a CDRL1 with the amino acid sequence shown in SEQ ID NO:4; a CDRL2 with the amino acid sequence shown in SEQ ID NO:5; and a CDRL3 with the amino acid sequence shown in SEQ ID NO:6, wherein said antibody comprises a heavy chain selected from the group consisting of: the amino acid sequence shown in SEQ ID NO: 9, the amino acid sequence shown in SEQ ID NO: 17, and the amino acid sequence shown in SEQ ID NO: 21; and a light chain selected from the group consisting of: the amino acid sequence shown in SEQ ID NO: 13 and the amino acid sequence shown in SEQ ID NO: 29.