Patent ID: 7799941
Filing Date: 2010-09-21
Classification: B01J,C07B,C07C

Abstract:
1. A process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative of formula (2) or (3) wherein R 1 is C 1-20 alkyl group which may be substituted either with C 4-12 aromatic group (the aromatic group may be substituted with halogen atom, C 1-6 alkyl group, C 1-6 alkoxy group, C 1-6 alkoxycarbonyl group, C 1-6 alkylcarbonyloxy group or CONR 4 R 5 wherein R 4 and R 5 are independently of each other are hydrogen atom or C 1-6 alkyl group), C 1-6 alkoxy group, C 1-6 alkoxycarbonyl group or CONR 4 R 5 wherein R 4 and R 5 are independently of each other are hydrogen atom or C 1-6 alkyl group, or R R or R characterized by comprising subjecting an α-aminoacyl acetic acid ester compound of formula (1) wherein R 1 and R 2 have the same meaning as the above, to hydrogenation by catalytic asymmetric hydrogenation in the presence of an acid, wherein the catalyst used for the catalytic asymmetric hydrogenation is a complex of ruthenium or iridium having an optically active phosphine ligand.