Patent ID: 7227128
Filing Date: 2007-06-05
Classification: G01J,G01N,H04N

Abstract:
1. A method of performing a biological assay using a detector comprising a plurality of pixel elements configured to resolve signal emissions arising from a biological sample, the method comprising: evaluating a plurality of response signals generated by each of the pixel elements resulting from exposure to a calibration signal while varying the intensity of the calibration signal in combination with varying of an acquisition time of the pixel elements; identifying systematic signal deviations in the detector and normalizing pixel element response by comparison of the response signals generated while varying the calibration signal intensity and acquisition time; and applying the systematic signal deviations and the pixel normalization to a measured raw data corresponding to the emitted signal from the biological sample wherein the response signals that yield the systematic signal deviations and the pixel normalization are obtained in a similar condition as that of the measured raw data.