Patent ID: 7879328
Filing Date: 2011-02-01
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of antagonizing B Lymphocyte Stimulator activity in an animal having systemic lupus erythematosus or rheumatoid arthritis comprising administering to the animal an antibody comprising a first amino acid sequence that is at least 85% identical to amino acid residues 1-123 of SEQ ID NO:327 and a second amino acid sequence that is at least 85% identical to amino acid residues 141-249 of SEQ ID NO:327, and wherein the antibody binds B Lymphocyte Stimulator selected from the group consisting of: (a) amino acid residues 1-285 of SEQ ID NO: 3228; (b) amino acid residues 134-285 of SEQ ID NO: 3228; and (c) a trimer comprising amino acid residues 134-285 of SEQ ID NO:3228.