Patent ID: 7682387
Filing Date: 2010-03-23
Classification: A61F,A61K,A61L,A61P

Abstract:
1. A method for inhibiting restenosis at a vascular injury site, comprising delivering to the vascular injury site, an endovascular metal stent having an open-lattice structure formed of linked filaments, and carried on the one or more filaments, a drug-release coating having a thickness of between 3–30 microns, and composed of (i) 20 to 80 weight percent polylactide polymer substrate and (ii) 20–80 weight percent macrocyclic triene compound as the sole active agent, and having the form: where R is CH 2 —CH 2 —OH; and expanding the stent at the vascular injury site, to bring the drug-release coating in contact with the vessel at the injury site, said coating being effective to release an amount of the compound to inhibit restenosis at the site.