Patent ID: 7851169
Filing Date: 2010-12-14
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for diagnosing the presence of Squamous Cell Carcinoma (SCC) comprising the steps of: a) contacting a sample suspected of comprising neoplastic epithelial cells with a monoclonal antibody capable of specifically binding a migration facilitating protein (MFP) of a laminin 5 alpha 3 chain G4-5 domain, or subdomain thereof, b) detecting the binding of said antibody to said MFP; and, c) diagnosing therefrom the presence or absence of SCC in said sample, wherein the antibody binds an epitope between (i) amino acid 1399 and amino acid 1713 of SEQ ID NO:2, (ii) amino acid 1375 and amino acid 1390 of SEQ ID NO:2, or (iii) amino acid 1358 and amino acid 1366 of SEQ ID NO:2.