Patent ID: 6706751
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of: compounds of formula (I) whereinU is O or a lone pair, V is a) O, S, NR1, or CH2, and L is lower-alkylene or lower-alkenylene, b) â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”, and L is lower-alkylene or a single bond, W is CO, COO, CONR2, CSO, CSNR2, SO2, or SO2NR2, X is hydrogen or one or more optional halogen and/or lower-alkyl substituents, m is 1, n is 0 to 7, A1 is hydrogen, lower-alkenyl, or lower-alkyl optionally substituted by hydroxy, lower-alkoxy, or thio-lower-alkoxy, A2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkinyl, or lower-alkyl optionally substituted by hydroxy, lower-alkoxy or thio-lower-alkoxy, A3 and A4 independently from each other are hydrogen or lower-alkyl, or A1 and A2 or A1 and A3 are bonded to each other to form a ring and â€”A1â€”A2â€” or â€”A1â€”A3â€” are lower-alkylene or lower-alkenylene, optionally substituted by R3, in which one â€”CH2â€” group of â€”A1â€”A2â€” or â€”A1â€”A3â€” can optionally be replaced by NR4, S, or O, A5 is cycloalkyl, cycloalkyl-lower-alkyl, heterocycloalkyl-lower-alkyl, aryl, aryl-lower-alkyl, heteroaryl, heteroaryl-lower-alkyl, lower-alkyl optionally substituted with hydroxy or lower-alkoxy, alkenyl optionally substituted with hydroxy, or alkadienyl optionally substituted with hydroxy, R3 is hydroxy, lower-alkoxy, thio-lower-alkoxy, N(R5, R6), or lower-alkyl optionally substituted by hydroxy, R1, R2, R4, R5, and R6 independently from each other are hydrogen or lower-alkyl; pharmaceutically acceptable salts of compounds of formula (I); and pharmaceutically acceptable esters of compounds of formula (I).