Patent ID: 8138334
Filing Date: 2012-03-20
Classification: A61P,B82Y,C07D

Abstract:
1. A compound according to Formula (I) pharmaceutically acceptable acid or base addition salts thereof, stereochemically isomeric forms thereof, N-oxide form thereof, or prodrug thereof, wherein: R X is a covalent bond or a bivalent radical of formula —O—, —S— or —NR Q is O or NR each R R n is an integer, equal to 0, 1 or 2; m is an integer, equal to 1 or 2, provided that if m is 2, then n is 1; Z is a covalent bond or a bivalent radical of formula —CH A each Alk is independently a covalent bond; a bivalent straight or branched, saturated or unsaturated hydrocarbon radical having from 1 to 6 carbon atoms; or a cyclic saturated or unsaturated hydrocarbon radical having from 3 to 6 carbon atoms; each radical optionally substituted on at least one carbon atom with at least one phenyl, halo, cyano, hydroxy, formyl or amino radical; Y is a covalent bond or a bivalent radical of formula —C(═O)—, —SO L is hydrogen, alkyl, alkenyl, alkyloxy, alkyloxyalkyloxy, alkylcarbonyloxy, alkyloxycarbonyl, mono- or di(alkyl)amino, mono- or di(alkyloxycarbonyl)amino, mono- or di(alkylcarbonyl)amino, mono- or di(Ar Ar Ar Ar Het alkyl is a straight or a branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms; each hydrocarbon radical optionally substituted on at least one carbon atom with at least one radical that is phenyl, halo, trihalomethyl, aminocarbonyl, methyl, ethyl, propyl, isopropyl, t-butyl, cyano, oxo, hydroxy, formyl or amino; and alkenyl is a straight or branched unsaturated hydrocarbon radical having from 1 to 6 carbon atoms and having at least one unsaturated bond; or a cyclic unsaturated hydrocarbon radical having from 3 to 6 carbon atoms and having at least one unsaturated bond; each hydrocarbon radical optionally substituted on at least one carbon atom with at least one radical that is phenyl, halo, cyano, oxo, hydroxy, formyl or amino.