Patent ID: 6649166
Filing Date: 2003-11-18
Classification: A61K,A61P,C12N

Abstract:
A polypeptide molecule capable of desensitizing a human subject to bee venom, the polypeptide selected from the group consisting of: (a) a polypeptide molecule corresponding to amino acid positions 85-97 of SEQ ID NO: 8; (b) a polypeptide molecule corresponding to amino acid positions 81-93 of SEQ ID NO: 8; (c) a polypeptide molecule corresponding to amino acid positions 94-106 of SEQ ID NO: 8; (d) a polypeptide molecule corresponding to amino acid positions 76-88 of SEQ ID NO: 8; (e) a polypeptide molecule corresponding to amino acid positions 77-94 of SEQ ID NO: 8; (f) a polypeptide molecule corresponding to amino acid positions 122-134 of SEQ ID NO: 8; and (g) a polypeptide molecule of (a)-(f) comprising at least one amino acid substitution, wherein the substituted polypeptide exhibits binding activity to MHC class II molecules identical to or greater than that of the polypeptides (a)-(f).