Patent ID: 6313115
Filing Date: 2001-11-06
Classification: A61K,A61P,C07D

Abstract:
A compound having the structure: ##STR5##in which:R.sup.1 is oxygen or sulfur;R.sup.2 and R.sup.3 are independently selected from the group consisting of --CR.dbd.and --CX.dbd.;M is .dbd.CR.sup.4 --, wherein R.sup.4 and R.sup.8 are independently R or together form a moiety which links M to the ring vertex 2' to form a ring, the moiety which links being selected from the group consisting of a single bond, --CRR`--, --CR.dbd.CR`--, --C(O)--, --O--, --S(O).sub.y --, --NR--, and --N.dbd.;R.sup.5 is --(CRR').sub.n --, ;R.sup.6 is --O--; andR.sup.7 is selected from the group consisting of--CRR'--, --C(O)--, --CXX`-- and --CRX--;whereinX and X' are independently selected from --Br, --Cl, --F, --CN, --NO.sub.2, --OR, --SR, --NRR',--C(O)R, --CO.sub.2 R, or --CONRR', wherein two groups R or R' on an individual group X, or on two adjacent groups X, may together form a ring; andR and R' are independently selected from (i) hydrogen, (ii) C.sub.1 -C.sub.6 branched or unbranched alkyl or C.sub.3 to C.sub.6 cycloalkyl groups, which may be unsubstituted or substituted with one or more functionalities selected from halogen, nitro, alkoxy, hydroxy, alkylthio, amino, keto, aldehyde, carboxylic acid, carboxylic ester, or carboxylic amide, and wherein when R and R` are alkyl groups, said alkyl groups may together form a ring, and (iii) aryl groups, which may be unsubstituted or substituted with one or more functionalities selected from halogen, nitro, alkoxy, hydroxy, aryloxy, alkylthio, amino, keto, aldehyde, carboxylic acid, carboxylic ester, or carboxylic amide;p is 0 or 1; andn is one and y is 0, 1 or 2.