Patent ID: 8242095
Filing Date: 2012-08-14
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method for modulating an immune response in a kidney allograft recipient, comprising: perfusing a kidney harvested from an organ donor with an effective amount of a gutless adenovirus carrying a nucleotide sequence encoding an immune modulator and a regulatory element operably linked to said nucleotide sequence; and transplanting the perfused kidney into a subject in need of a kidney transplant, wherein said gutless adenovirus expresses said immune modulator in said kidney, wherein said immune modulator is indoleamine dioxygenase, and wherein the gutless adenovirus is administered in an amount sufficient for reducing plasma creatinin levels, reducing tissue damage, reducing macrophage influx or reducing a fibrotic response in said recipient following transplantation, as compared to the amount observed in a control organ that received only saline.