Patent ID: 6660729
Filing Date: 2003-12-09
Classification: A61K,A61P

Abstract:
A composition comprising a fused pyrrolocarbazole with the formula: whereinR3 and R4 are selected from H, alkyl, Cl, Br, CH2OH, CH2SOCH2CH3, CH2SO2CH2CH3, NHCONHC6H5, CH2SCH2CH3, CH2SC6H5, NHCO2CH3, CH2OC(&boxH;O)NHCH2CH3, N(CH3)2, CH&boxH;NNH, CH2N(CH3)2, and CH2OCH2CH3; R7 is selected from H and alkyl; and R15 and R16 are independently selected from H, alkyl, OH, CH2OH, alkoxy, and CO2alkyl; or a stereoisomer or pharmaceutically acceptable salt form thereof; a surfactant is present at least about 20% (w/w) and is selected from a polyoxyethylene sorbitan fatty acid ester, a polyethylene glycol ether, a saturated polyglycolized glyceride, a fatty acid ester of polyethylene glycol, a hydroxylated lecithin, a medium chain monoglyceride, a medium chain fatty acid ester, a polyethylene/propylene glycol copolymer, a poloxyl stearate, a poloxyl castor oil, a polyethylene glycol hydroxystearate, and a d-&agr;-tocopheryl polyethylene glycol succinate; and an organic solvent selected from propylene glycol, propylene carbonate, dimethyl isosorbide, and polyethylene glycol.