Patent ID: 7666584
Filing Date: 2010-02-23
Classification: A61P,C12Q,G01N

Abstract:
1. A method of diagnosing high grade prostatic intraepithelial neoplasia in a human suspected of having high grade prostatic intraepithelial neoplasia, said method comprising: a. obtaining a biological sample from said human; b. determining the level of ATP-binding cassette transporter 5 polypeptide in said biological sample; c. comparing the level of ATP-binding cassette transporter 5 polypeptide in said biological sample with the level of ATP-binding cassette transporter 5 polypeptide in a biological sample obtained from a like human not afflicted with high grade prostatic intraepithelial neoplasia; wherein said biological sample is selected from the group consisting of a urine sample and a prostate tissue sample; wherein said ATP-binding cassette transporter 5 polypeptide comprises the polypeptide of SEQ ID NO: 2; and wherein when a higher level of ATP-binding cassette transporter 5 polypeptide is determined in said biological sample from said human as compared with the level of ATP-binding cassette transporter 5 polypeptide in said biological sample from said like human, the human is diagnosed with high grade prostatic intraepithelial neoplasia.