Patent ID: 8562956
Filing Date: 2013-10-22
Classification: A61K,A61P,A61Q

Abstract:
1. A method of making an antiperspirant active composition comprising: I) heating an aqueous solution containing an aluminum and chloride salt having an aluminum to chloride molar ratio of about 0.3:1 to about 3:1, optionally with a buffer agent, at a temperature of about 50° C. to about 95° C. to reflux for a period of time of about 1 hour to about 5 hours to obtain an aluminum salt solution; and II) adding an aqueous solution of an inorganic base to the aluminum salt solution to obtain an aluminum salt solution having an OH:Al molar ratio of about 2:1 to about 2.6:1 to obtain a pH adjusted aluminum salt solution having a pH of about 2 to about 5, wherein the OH is provided by at least one of the inorganic base and the aluminum and chloride salt; and III) optionally adding an aqueous solution containing a zirconium compound to the pH adjusted aluminum salt solution to thereby obtain an aluminum-zirconium salt solution having a molar ratio of aluminum to zirconium of about 5:1 to about 10:1, wherein at least one of: (i) the antiperspirant active composition has a Size Exclusion Chromatography (SEC) chromatogram Peak 4 area of at least 60% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram, and (ii) the antiperspirant active composition exhibits a Size Exclusion Chromatography (SEC) chromatogram having a SEC Peak 4 to Peak 3 intensity ratio of at least 7 and a Peak 4 intensity greater than a Peak 5 intensity in aqueous solution.