Patent ID: 6630472
Filing Date: 2003-10-07
Classification: A61P,C07D

Abstract:
A compound of formula: wherein:R1 is: hydrogen; an aryl group unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, NO2, CF3, C1-C6 alkyl, C2-C6 alkenyl, C1-C4 alkyloxy, C2-C4 alkenyloxy, benzyloxy, phenoxy, amino, and phenyl; an alkyl or alkenyl group unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, C4-C6 cycloalkenyl, and hydroxy; adamantyl, C3-C8 cycloalkyl or C5-C7 cycloalkenyl group unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, C1-C4 alkyloxy, and hydroxy; or C(R11)(R12)(R13), where R11 and R12 are each independently lower alkyl, or R11 and R12 together with the atom to which they are bound form cycloalkyl, and R13 is H, OH, lower alkyl, aryl, or (CH2)nâ€”Oâ€”W1, where n is 0, 1, 2, or 3, and W1 is R2 or C(O)R2, with R2 being C1-C3 alkyl unsubstituted or substituted with one or two methoxy groups; X is hydrogen, cyano, C1-C2 alkyloxy, dimethoxymethyl, or &boxH;O; and Y is hydrogen or an alkyl, alkenyl, benzyl, or cycloalkyl group unsubstituted or substituted with one or more substituents independently selected from the group consisting of: alkyl; aryl; alkoxy; hydroxyalkyl; aryloxy; alkenyloxy; hydroxy; benzyloxy; phenoxy; (CH2)pâ€”Oâ€”W2 and (CH2)pâ€”Nâ€”W2 where p is 0, 1 or 2 and W2 is R3or C(O)R3, where R3 is an aryl, alkyl, or alkenyl group unsubstituted or substituted with one or more substituents independently selected from the group consisting of aryl, alkyl, and alkoxy; and (CH2)pâ€²â€”C(O)â€”Oâ€”W2â€² and (CH2)pâ€²â€”C(O)â€”Nâ€”W2â€², where pâ€² is 0, 1, or 2, and W2 is an alkyl; or X and Y, together with the carbon ring atom and nitrogen heteroatom to which they are respectively bonded, form a 5- to 7-membered saturated or unsaturated heterocyclic ring unsubstituted or substituted with one or more substituents J, K, and L; where J, K, and L represent substituents independently selected from the group consisting of oxo, and C3-C5 cycloalkyl and C1-C5 alkyl groups unsubstituted or substituted with one or more substituents independently selected from the group consisting of C3-C5 cycloalkyl, methoxy, methoxyphenyl, and dimethoxyphenyl; or where J and K together form a phenyl ring unsubstituted or substituted with one or more substituents independently selected from the group consisting of methoxy, trifluoromethyl, trifluoromethoxy, and substituents linked to the phenyl ring through oxygen, nitrogen, carbon or sulfur and independently selected from the group consisting of halogen, hydroxyl, NO2, CF3, C1-C6 alkyl, C2-C6 alkenyl, C1-C4 alkyloxy, C2-C4 alkenyloxy, benzyloxy, phenoxy, amino, and phenyl; or a pharmaceutically acceptable salt of said compound.