Patent ID: 6436897
Filing Date: 2002-08-20
Classification: A61K,A61P

Abstract:
An IGF-I and IGFBP-3 complex formulation, comprising:(a) IGF-I/IGFBP-3 complex, wherein said IGF-I is naturally occurring IGF-I, a variant in which one or more tyrosine residue is replaced with a non-aromatic residue, or a variant in which one or more of residues 49, 50, 51, 53, 55, or 56 are altered, and said IGFBP-3 is naturally occurring IGFBP-3, a variant in which one or more of residues 89, 109, or 172 are altered from asparagine to aspartate, a variant in which one or more of positions 116 or 135 are altered from aspartate to glutamate, or a variant in which one or more of residues 228, 230, 215, 216 or 231 is altered; (b) a bulking agent, and (c) pH buffer salts, wherein said formulation contains less than 12.5 mM osmolyte salts.