Patent ID: 6475773
Filing Date: 2002-11-05
Classification: C12P

Abstract:
A process for preparing a chiral ester expressed in formula 100 by mixing and reacting:an alkenyl ester expressed by formula 6; a ruthenium complex selected from the group consisting of compounds 1 and 2 expressed in formulas 1 and 2 to activate reduction reaction of said alkenyl ester and racemization; a lipase to acylate selectively one of enantiomers of said alkenyl ester; and a reducing agent to supply a hydride to said ruthenium complex, wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, and Y12 are a hydrogen atom or C1-C5 alkyl group; X is Br, Cl or I; and Q is H, Br, Cl, or I; wherein Ph is phenyl; wherein R1, R2 and R3 are, independently, chosen from H, and optionally substituted alkyl, optionally substituted aryl, or optionally substituted cycloalkyl groups; and R1 and R2, R1 and R3, and R2 and R3 can be cyclized with each other, where said substituent of alkyl, aryl and cycloalkyl is a halogen atom or a cyano group.