Patent ID: 6503948
Filing Date: 2003-01-07
Classification: A61K,A61P,Y10S

Abstract:
A method for treating an organ donor prior to harvesting an organ to reduce graft rejection in a recipient, the method comprising the steps of:administering to the organ donor an amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulas I, II, III, IV, V, VI, and VII: â€ƒwherein Y is X is F or Cl; R1 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R2 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R3 is H or a straight or branched alkyl group having from 1 to 7 carbon atoms; Z is H, OH, or a straight or branched alkyl group including from 1 to 7 carbon atoms; and in Formula II, the OH groups may be substituted anywhere except where Y is present and are not on the same carbon atom; in Formula III, the OH group may be substituted anywhere except where Y is present; in Formula IV, the OH group may be substituted anywhere except where Y is present; in Formula V, Z may be substituted anywhere except at C-1, C-6, and C-4 if Z is OH; in Formula VI, Z may be substituted anywhere except at C-1, C-3, and C-5 if Z is OH; and in Formula VII, Z may be at C-1, C-2, and C-3 except not on C-1 if Z is OH.