Patent ID: 6031127
Filing Date: 2000-02-29
Classification: C07F,Y02P

Abstract:
A process for preparing L-P-boronophenylalanine of the following formula: ##STR14## said process comprising the steps of: preparing a triflate compound represented by the following formula: ##STR15## wherein Tf represents trifluoromethanesulfonly group; and Y is a protective group selected from the group consisting of benzyloxycarbonyl group, allyloxycarbonyl group, and t-butoxycarbonyl group; and Bn is an benzyl group, from a starting material selected from the group consisting of N-t-butoxycarbonyl-L-thyrosine, N-allyloxycarbonyl-L-thyrosine and N-benzyloxycarbonyl-L-thyrosine,reacting the triflate compound with tetraalkoxydiboron represented by the following formula: ##STR16## to obtain a compound of the formula: ##STR17## wherein Y and Bn are as defined above, and subjecting said compound to hydrogenation reaction in the presence of a palladium series catalyst.