Patent ID: 6548499
Filing Date: 2003-04-15
Classification: C07D

Abstract:
A compound of Formula I: wherein A is wherein R3, R3a, and R3bare each independently the same or different and are hydrogen,alkyl, aryl-SO2â€”, aryl, heteroaryl, â€”OR4 wherein R4 is hydrogen, alkyl, aryl, aralkyl, acetyl, or â€ƒwherein R5 and R6 are each the same or different and are hydrogen, alkyl, cycloalkyl, acetyl, â€”(CH2)mâ€”OH, or R5 and R6 are taken together to form a 5- to 7-membered ring optionally containing an oxygen atom or Nâ€”R4 wherein R4 is as defined above and m is an integer of 2 to 5, â€ƒwherein n is zero or an integer of 1 and R7 and R8 are each independently the same or different and are hydrogen, alkyl, aryl, aralkyl, acetyl, or â€ƒwherein R5 and R6 are as defined above or R7 and R8 taken together to form a 5- to 7-membered ring optionally containing an oxygen atom or Nâ€”R4 wherein R4 and m are as defined above, â€ƒwherein R7, R8, and n are as defined above, â€ƒwherein R7, R8, and n are as defined above, â€”(CH2)nâ€”SO2OR4 wherein R4 and n are as defined above, â€”(CH2)nâ€”CO2R4 wherein R4 and n are as defined above, â€”CH2OR4 wherein R4 is as defined above, halogen, CF3, CBr3, CCl3, or NO2; â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3bare as defined above, â€ƒwherein R3, R3a, and R3bare as defined above, â€ƒwherein R3, R3a, and R3bare as defined above, â€ƒwherein R3, R3a, and R3bare as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R14 is hydrogen, alkyl, aryl, or aralkyl, and R3 and R3a are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3 and R3a are as defined above, â€ƒwherein R3 and R3a are as defined above, â€ƒwherein R3, R3a, and R14 are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3 is as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3 and R3a are as defined above, â€ƒwherein R3 and R3a are as defined above, â€ƒwherein R3 and R3a are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, â€ƒwherein R3, R3a, and R3b are as defined above, R2 is CF3, CCl3, CBr3, or â€ƒwherein R10 is hydrogen, alkyl, or aralkyl, and â€ƒwherein n, R5, and R6 are as defined above, â€ƒwherein R5, R6, and m are as defined above, â€ƒwherein R12 and R12a are each independently the same or different and are hydrogen, alkyl, or aryl, or taken together can form a 5- to 7-membered ring, and R13 is hydrogen or alkyl, and m is as defined above, â€ƒwherein m, R12, R12a, and R13 are as defined above, â€ƒwherein R9 and m are as defined above, â€ƒwherein R9 and m are as defined above, â€ƒwherein m and o are as defined above, â€ƒwherein n, o, R5, and R6 are as defined above, â€ƒwherein n and R9 are as defined above, â€ƒwherein n is as defined above, â€ƒwherein n is as defined above, â€ƒwherein m is as defined above, or R10 and R11 when taken together can form a 5- to 7-membered ring optionally containing an oxygen atom or Nâ€”R4 wherein R4 is as defined above; or a pharmaceutically acceptable salt thereof.