Patent ID: 6495539
Filing Date: 2002-12-17
Classification: A61P,C07D

Abstract:
A compound of the formula and the salts and hydrocarbyl esters of the carboxylic acid at position 2whereinZ is S, SO, or SO2, each of R1, R2 and R3 is independently H, substituted or unsubstituted aryl (6-14C), substituted or unsubstituted pyridyl, substituted or unsubstituted arylcarbonyl (7-15C), substituted or unsubstituted arylalkyl (7-15C) wherein substituents on any alkyl moiety are selected from the group consisting of halo, and RO, wherein R is H or alkyl (1-6C), and substituents on any aryl or pyridyl moiety are selected from the group consisting of halo, â€”CN, CF3, and RO, where R is H or alkyl (1-6C); with the proviso that R1 is not H and R1 and R3 are not identical, and wherein in formula (1), the B ring may optionally contain one double bond that is located between positions 2 and 3, as indicated by the dotted line.