Patent ID: 6013658
Filing Date: 2000-01-11
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound of formula I whereinm is 1 or 2;p is 0, 1 or 2;A is ##STR176## wherein R.sup.1 is hydrogen or C.sub.1-6 alkyl,W is .dbd.OB is ##STR177## wherein R.sup.2 is hydrogen or C.sub.1-6 -alkyl,W' is .dbd.O or .dbd.S;D is ##STR178## wherein R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently are hydrogen or C.sub.1-6 -alkyl optionally substituted with halogen, amino, hydroxy or aryl;R.sup.5 and R.sup.6, R.sup.6 and R.sup.7, R.sup.5 and R.sup.8 or R.sup.7 and R.sup.8 optionally forming --(CH.sub.2).sub.i --U--(CH.sub.2).sub.j --, wherein i and j independently are 1 or 2, andU is --O--, --S-- or a valence bond;M is --O--, --S--, --CH.dbd.CH--, ##STR179## optionally substituted with halogen, amino, hydroxy, C.sub.1-6 -alkyl or C.sub.1-6 alkoxy;o, r and t are independently 0, 1, 2, 3 or 4;q and s are independently 0 or 1;and r+s+t is 1, 2, 3 or 4;E is hydrogen or ##STR180## R.sup.12 is hydrogen, --COOR.sup.15, --CONR.sup.16 R.sup.17, --(CH.sub.2).sub.v NR.sup.16 R.sup.17, --(CH.sub.2).sub.u OR.sup.15, halogen, hydroxy, C.sub.1-6 alkyl, phenyl, oxazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, R.sup.15, R.sup.16 and R.sup.17 independently are hydrogen or C.sub.1-6 -alkyl optionally substituted with aryl, and u and v are independently 0 or 1, 2, 3, 4, 5 or 6;G is hydrogen, ##STR181## optionally substituted with halogen, amino, hydroxy, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy;J is ##STR182## optionally substituted with halogen, amino, hydroxy, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy;or a pharmaceutically acceptable salt thereof, and the compounds of formula I comprise any optical isomers thereof, in the form of separated, pure or partially purified optical isomers or racemic mixtures thereof.