Patent ID: 6750349
Filing Date: 2004-06-15
Classification: A61P,C07D,Y02P

Abstract:
A compound of formula (V) whereinR4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, or C2-6alkenyl, or L is a radical of formula â€”Alkâ€”R6â€ƒâ€ƒ(b-1), â€”Alkâ€”Xâ€”R7â€ƒâ€ƒ(b-2), â€”Alkâ€”Yâ€”C(&boxH;O)â€”R9â€ƒâ€ƒ(b-3), orâ€”Alkâ€”Yâ€”C(&boxH;O)â€”NR11R12â€ƒâ€ƒ(b-4), â€ƒwherein each Alk is C1-12alkanediyl; and R6is hydrogen, hydroxy, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or Het1; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or Het2; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen or C1-6alkyl; R11 and R12 each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11 and R12 combined with the nitrogen atom bearing R11 and R12 may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C1-6alkyl, amino or mono or di(C1-6alkyl)amino, or said R11 and R12 combined with the nitrogen bearing R11 and R12 may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C1-6alkyl; and Het1 and Het2 each independently are selected from furan; furan substituted with C1-6alkyl or halo; tetrahydrofuran; a tetrahydrofuran substituted with C1-6alkyl; a dioxolane; a dioxolane substituted with C1-6alkyl, a dioxane; a dioxane substituted with C1-6alkyl; tetrahydropyran; a tetrahydropyran substituted with C1-6alkyl; pyrrolidinyl; pyrrolidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, or C1-6alkyl; pyridinyl; pyridinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C1-6alkyl; pyrimidinyl; pyrimidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano, C1-6alkyl, C1-6alkyloxy, amino and mono and di(C1-6alkyl)amino; pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from hydroxy, C1-6alkyloxy, C1-6alkyl or halo; pyrazinyl; pyrazinyl substituted with one ore two substituents each independently selected from halo, hydroxy, cyano, C1-6alkyl, C1-6alkyloxy, amino, mono- and di(C1-6alkyl)amino and C1-6alkyloxycarbonyl; Het1 can also be a radical of formula Het1 and Het2 each independently can also be selected from the radicals of formula R13 and R14 each independently are hydrogen or C1-4alkyl and the OR4 radical is situated at the 3-position of the central piperidine moiety.