Patent ID: 7368464
Filing Date: 2008-05-06
Classification: C07D

Abstract:
1. A process for the preparation of 1,2,4-triazol-1-yl methyloxiranes of the formula I in which A and B are identical or different and, independently of one another, are C 1 -C 4 -alkyl, phenyl-C 1 -C 2 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, tetrahydropyranyl, tetrahydrofliranyl, dioxanyl or phenyl, where the phenyl radical can carry one to three substituents chosen from the group: halogen, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkyloxy, phenoxy, amino, C 1 -C 2 -haloalkyl or phenylsulfonyl, which comprises reacting a) an oxirane of the formula II in which A and B have the meanings given above and L is a nucleophilically substitutable leaving group, with 4-amino-1,2,4-triazote of the formula III to give 4-amino-1,2,4-triazolium salts of the formula IV and b) deaminating the 4-amino-1,2,4-triazolium salts IV with alkali metal nitrites and acid or organic nitrites to give 1,2,4-triazol-1-yl methytoxiranes of the formula I.