Patent ID: 7132449
Filing Date: 2006-11-07
Classification: A61P,C07D

Abstract:
1. A compound according to general formula (I): wherein: R R Y=CHR  where L is a number from one to four and R in (X) in (W) in (V) Z=O (in which case compounds of general formula (I) may be named as (2-alkyl-4-oxo-tetrahydrofuran-3-yl)amides), S (in which case compounds of general formula (I) may be named as (2-alkyl-4-oxo-tetrahydrothiophen-3-yl)amides), or CH U=a stable 5- to 7-membered monocyclic or a stable 8- to 11-membered bicyclic ring which is either saturated or unsaturated and which includes zero to four heteroatoms (as detailed below): wherein R A is chosen from: B, D and G are independently chosen from: E is chosen from: J, L, M, R, T, T T provided that when Z is O or S and Y is CHR 3 CO (wherein R 3 is not hydrogen or unsubstituted C 0-7 alkyl): either o=0, m=1 and V is not CR 12 R 13 ; or o=0, n=0, m=2 or 3 and the V group directly attached to the substituent Y is not CR 12 R 13 ; provided that when Z is O and Y is CHR 3 CO: either o=0, n≠0; or o=0, n=0, m=1 and V is not OC(O)NH, SO 2 NH or C(O)NH; or o=0, n=0, m=2 or 3 and the V group directly attached to the substituent Y is not OC(O)NH, SO 2 NH or C(O)NH.