Patent ID: 7354933
Filing Date: 2008-04-08
Classification: A61P,C07D

Abstract:
1. The compound of formula I: wherein p is 0, R and R1, which may be identical or different, are O or NH, R2 and R3, which may be identical or different, are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, hydroxyphenylalkyl, thienylbenzothienylalkyl, phenylalkyl, pyridylalkyl, benzothienylalkyl, aryl or heteroaryl, the phenylalkyl, pyridylalkyl, and benzothienylalkyl being optionally substituted with one or more radicals chosen from halogen, hydroxyl, alkyl and alkoxy containing from one to four carbon atoms, A1 is single bond, alkyl, alkenyl or alkynyl, Y and Y1, which may be identical or different, are such that one of Y and Y1 is —OCF or the is that is optionally substituted with one or more alkyl that are optionally substituted, q is 2, 3 or 4, R5 and R6, which may be identical or different, are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl or heteroaryl, or R5 and R6 taken together with the nitrogen atom to which they are attached form a 3- to 10-membered heterocyclyl containing one or more hetero atoms chosen from O, S, N and NR7, A2, which may be identical to or different from A1, is defined as A1 or is CO or SO B2 is a saturated or unsaturated 3- to 10-membered monocyclic or bicyclic heterocyclyl containing one or more hetero atoms chosen from O, S, N and NR7 that is optionally substituted with one or more identical or different substituents defined as Y2, R7 is hydrogen, alkyl, cycloalkyl, phenyl, acyl, —S(O) Y2 is hydrogen, halogen, hydroxyl, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, phenyl optionally substituted with —NR5R6, heteroaryl, —O-alkenyl, —O-alkynyl, —O-cycloalkyl, —S(O) all the alkyl, alkenyl, alkynyl and alkoxy above are linear or branched and contain not more than 6 carbon atoms, all the cycloalkyl and heterocyclyl above contain not more than 7 carbon atoms, all the aryl and heteroaryl above contain not more than 10 carbon atoms, all the carbocyclyl, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl and heteroaryl above, and also the ring formed by R5 and R6 with the nitrogen atom to which they are attached, are optionally substituted with one or more substituents, which may be identical or different, selected from the group consisting of halogen, cyano, hydroxyl, alkoxy, —CF all the aryl and heteroaryl above are optionally substituted with one or more substituents selected from the group consisting of alkyl, alkoxy and alkylenedioxy, all the cyclic radicals above, and also the ring formed by R5 and R6 with the nitrogen atom to which they are attached, are optionally substituted with one or more substituents selected from the group consisting of oxo and thioxo, n is 0 to 2, R8 is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, R9 is defined as R8 or is hydrogen, R10 is hydrogen or alkyl, R11 and R12, which may be identical or different, are hydrogen, C or R11 and R12 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered cyclic radical containing one or more hetero atoms chosen from O, S, N and NR7, and R13, which may be identical to or different from R5 or R6, is defined as R5 or R6, or a racemic, enantiomeric or diastereoisomeric isomer form of the compound of formula I, or an addition salt with a mineral or organic acid or with a mineral or organic base thereof, with the proviso: a) when p is 0, R and R1 are oxygen, A1 is single bond or alkyl, Y and Y1, which may be identical or different, are at least one is —OCF b) when p is 0, R and R1 are oxygen, A1 is a single bond or alkyl, Y and Y1, which may be identical or different, are at least one is —S(O) c) when p is 0, R and R1 are oxygen, A1 is single bond, Y and Y1, which may be identical or different, are one is —SO