Patent ID: 6555529
Filing Date: 2003-04-29
Classification: A61K

Abstract:
A method of treating patients with bone marrow abnormalities, comprising the step of:administering an effective amount of a methanebisphosphonic acid derivative represented by formula (Ia), â€ƒwherein, in formula (Ia), B represents â€”Xâ€”(CH2)nâ€”; n is an integer in the range of 0 to 6; X represents S, O, or NH; Y represents a substituted or unsubstituted straight chain or branched chain lower alkyl, comprising 1 to 6 carbon atoms, wherein the substituents are amino, lower alkylamino, di-lower alkylamino or tri-lower alkylsiloxy, or substituted or unsubstituted phenyl, wherein the substituents are lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl, or halogen; Z denotes a lower alkyl group, trifluoromethyl group, lower alkenyl, lower alkoxy, lower alkylthio or C3-8 cycloalkyl; and m is an integer in the range of 0 to 2.