Patent ID: 8026383
Filing Date: 2011-09-27
Classification: C07C,C12P,Y02P

Abstract:
1. A process for the preparation of an intermediate compound of formula VI suitable for the preparation of statin derivatives, which process comprises reaction of an intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH wherein Y wherein Y a compound of formula III wherein X wherein X wherein R and the compound of formula V so obtainable is then reduced to the corresponding amino compound of formula VI wherein R wherein in the processes mentioned above, at any stage, even where not explicitly mentioned, if necessary one or more or all of the protecting groups present in the compounds of formulae I to VI in question are removed or one or more or all of the functional groups that are not to participate in a reaction, or that would interfere with the reaction, are converted into protected groups by the introduction of suitable protecting groups, and it being possible for the compounds of formulae Ito VI, where salt-forming groups are present and the reaction in question is not impaired, also to be in salt form.