Patent ID: 7648703
Filing Date: 2010-01-19
Classification: A61K,A61P,C07K

Abstract:
1. A combination comprising: an anti-Ep-CAM antibody with a chemotherapeutic agent wherein the chemotherapeutic agent is capable of arresting cell cycle production in S and/or G2/M in Ep-CAM expressing tumor cells and increasing the density of the Ep-Cam antigen population of the Ep-CAM expressing tumor cells, selected from the group consisting of: UFT, Capecitabine, CPT-II, Oxaliplatin, Paclitaxel, Docetaxel, Cyclophosphamide, Methotrexate, Doxorubicin, Navelbine (iv and oral), Epirubicin, Mitoxantrone, Raloxifen, Cisplatin, Carboplatinum, Gemcitabine, Etoposide and Topotecan.