Patent ID: 8865968
Filing Date: 2014-10-21
Classification: A01N,C07K,C12N

Abstract:
1. A method for controlling fungal growth on a cell or an organism or for preventing fungal infestation of a cell or an organism susceptible to fungal infection, comprising contacting fungal cells with a composition comprising a double-stranded RNA from outside the fungal cell(s), wherein the double-stranded RNA comprises annealed complementary strands, one of which comprises a nucleotide sequence selected from the group consisting of: (i) nucleotide sequences complementary to at least 21 contiguous nucleotides of the nucleotide sequence of a fungal target gene represented by SEQ ID NOs: 9 or 45, (ii) nucleotide sequences complementary to at least 21 contiguous nucleotides of a nucleotide sequence encoding the amino acid sequence represented by SEQ ID NO: 10, and (iii) nucleotide sequences at least 85% identical to the nucleotide sequences of (i), whereby the double-stranded RNA is taken up into the fungal cells and whereby the inhibition of said fungal target gene decreases or stops fungal infestation.