Patent ID: 8901327
Filing Date: 2014-12-02
Classification: C07D,C07F

Abstract:
1. A process for preparing cabazitaxel, the process comprising the steps of: a) treating 10-deacetylbaccatin of Formula (III) with a silylating agent in presence of a base and a suitable organic solvent for 1 to 10 hours to obtain a compound of Formula (IV); b) methylating the compound of Formula (IV) in the presence of a base and a methylating agent to obtain a compound of Formula (V); c) deprotecting the silyl group of the compound of Formula (V) in the presence of a suitable organic solvent and a base to obtain a compound of Formula (VI); d) methylating the compound of Formula (VI) in the presence of a suitable organic solvent and a base to obtain a compound of Formula (II); and e) optionally converting the compound of Formula II to cabazitaxel.