Patent ID: 6765097
Filing Date: 2004-07-20
Classification: C07D

Abstract:
A process for the preparation of 4-(2â€²-pyridyl)benzaldehyde comprising:reacting an arlymagnesium halide of the formula â€ƒwherein X1 represents Cl, Br or I; R1 and R2 which are the same or different from one another, represent linear or branched C1-C6 alkyls or, alternatively, R1 and R2 together represent a single linear or branched C1-C6 alkylene group, with a halopyridine of formula â€ƒwherein X2 represents Cl, Br, or I, in the presence of a catalytic amount of Zinc salt and a catalytic amount of Palladium, the molar ratio of the palladium to the halopyridine of formula 2 being less than 1:1000, to create an intermediate compound; and (b) converting the acetal group into a carbonyl group by acidic hydrolysis.