Patent ID: 6331628
Filing Date: 2001-12-18
Classification: B01J,C07B,C07C,C07D

Abstract:
A process for the preparation of benzonitrile compounds having the formula (1): ##STR6##wherein:X is hydrogen, fluorine or chlorine;Z is C.sub.1 -C.sub.4 alkylsulfonylamino, bis (C.sub.1 -C.sub.4 alkylsulfonyl)amino, (C.sub.2 -C.sub.5 alkoxycarbonyl)amino, (C.sub.2 -C.sub.5 alkylcarbonyl)amino, (optionally substituted benzoyl)amino, (C.sub.2 -C.sub.5 alkylcarbonyl) (C.sub.1 -C.sub.4 alkylsulfonyl)amino or (optionally substituted benzoyl) (C.sub.1 -C.sub.4 alkylsulfonyl)amino; andQ is 6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione-3-yl, 1-methyl-6-trifluoromethyl-2,4(1H, 3H)pyrimidinedione-3-yl or 1-amino-6-trifluoromethyl-2,4(1H, 3H)pyrimidinedione-3-yl group, which process comprises reacting a halogenated benzene compound having the formula (1a): ##STR7##wherein X, Z and Q are as defined above; and Y is fluorine, chlorine, bromine or iodine; provided that if X is fluorine, then Y is chlorine, bromine or iodine; and if X is chlorine; then Y is bromine or iodine; with one or more cyanides selected from the group consisting of potassium cyanide, sodium cyanide and zinc cyanide in the presence of a metallic catalyst, comprising:iron, cobalt, nickel, ruthenium, rhodium, palladium, iridium, platinum, or osmium.