Patent ID: 9163054
Filing Date: 2015-10-20
Classification: C07H

Abstract:
1. A method for F-18 FLT synthesis, comprising steps of: (a) processing ion exchange with fluoride ions to obtain fluorine(F)-18 ions with coordination of an ion-exchange resin; (b) with coordination of tertiary butyl alcohol (TBA), obtaining F-18 ions to be added with acetonitrile (ACN) and helium gas to process co-boiling; wherein said co-boiling process is processed at a temperature of 75° C.˜150° C. for a time period of 5 minute (min)˜1 min after cooling down to a room temperature, processing co-boiling again with ACN and helium gas; and cooling down to a room temperature; (c) obtaining reactant to be added with ACN and t-BuOH to process fluoridation under a pressure; (d) adding HCl to said reactant to process hydrolysis by heating; (e) after cooling down said reactant, processing purification through solid extraction with coordination of water; (f) processing dilution and filtration to said reactant to obtain a product; and (g) putting said product into a product collecting trough.