Patent ID: 6783763
Filing Date: 2004-08-31
Classification: A61K,A61P,C07K,C12N

Abstract:
A polyepitope of E6 protein from HPV, comprising 17 amino acids delimited by amino acids located in positions 46 and 62, or to 22 amino acids delimited by amino acids located in positions 46 and 67 of the peptide sequence of the E6 protein of HPV, characterized by the peptide sequence SEQ ID NO: 6 as follows:(46)RREVYDFAFRDLCIVYRDGNPY(67) said peptide sequence contains 6 epitopes binding stably to at least one of the 10 HLA molecules of the following types: A2, A3, A11, A24, A29, B7, B27, B35, B44, or B51, said epitopes being the following:(46)RREVYDFAFR(55) binding stably to HLA molecules of the B27 type, (49)VYDFAFRDL(57) binding stably to HLA molecules of the A24 type, (50)YDFAFRDL(57) binding stably to HLA molecules of the A29 or B44 type, (52)FAFRDLCIV(60) binding stably to HLA molecules of the A2, B35, B51, or B7 type, (54)FRDLCIVYR(62) binding stably to HLA molecules of the A3 or All type, and (59)IVYRDGNPY(67) binding stably to HLA molecules of the A3 or All type.