Patent ID: 6548661
Filing Date: 2003-04-15
Classification: C07H

Abstract:
A method for the modification of alcohols on polymer supports comprising:O-silylating an alcohol RCâ€”OH, wherein RC is a linear or branched acyclic, cyclic or multicyclic moiety, said moiety being optionally unsaturated and/or substituted by at least one hydrogen, ORi, amino, alkyl- or dialkylamino, NHCORi, halogen, CH2OH, CH2ORi, a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono-, di- or tri)acyloxyalkyl, arylalkyl or aryl group; wherein Ri is hydrogen, CHO, COORii, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group aryl, alkylaryl or arylalkyl; wherein if RC is cyclic, said moiety is optionally aromatic and/or heterocyclic; or if multicyclic, said moiety is optionally a fused multicyclic, fully or partially aromatic and/or heterocyclic, with X2SiRARB, wherein X is a halogen, and RA and RB are each independently a C1-6 linear or C3-10 branched chain alkyl or an aryl group, in the presence of a base under conditions to form a halosilyl compound; and coupling said halosilyl compound with a polymeric alcohol support in the presence of a base under conditions to form a polymer-linked composition having the structure: wherein RA and RB are each independently a C1-6 linear or C3-10 branched chain alkyl or an aryl group; wherein  is a polymeric support; wherein L is a linker selected from the group consisting of a single bond; a saturated or unsaturated oligomethylene chain, said oligomethylene chain being optionally interrupted by oxygen or sulfur atoms, an alkyl- or arylamino moiety, NHâ€”CO or COâ€”NH; a 1,4-phenylene; or a 1,4-phenylenemethylene moiety, said moiety being optionally substituted by at least one linear or branched alkyl or alkoxy group and/or halogen atom, whereby said polymer-linked composition comprises at least one reactive moiety so that the polymer-linked composition can be subjected to one or more chemical reactions to generate a modified polymer-linked composition.