Patent ID: 7056935
Filing Date: 2006-06-06
Classification: A61K,C07D

Abstract:
1. A method for stimulating neurite outgrowth by a nerve cell, comprising: administering to said nerve cell an effective amount of compound having an affinity for FKBP-type immunophilins according to formula I or a pharmaceutically acceptable salt thereof, wherein Y is CH wherein Z and R wherein Q is hydrogen, (C1–C6)-straight or branched alkyl or (C1–C6)-straight or branched alkenyl; wherein T is Ar or substituted 5–7 membered cycloalkyl with substituents at positions 3 and 4 which are independently selected from the group consisting of hydrogen, hydroxyl, O—(C1–C4)-alkyl or O—(C1–C4)-alkenyl and carbonyl; wherein Ar is selected from the group consisting of monocyclic and bicyclic heterocyclic aromatic ring systems with individual ring sizes being 5 or 6 which may contain in either or both rings a total of 1–4 hetero atoms independently selected from oxygen, nitrogen and sulfur; wherein Ar may contain one to three substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, hydroxymethyl, nitro, CF wherein R wherein U is hydrogen, O—(C1–C4)-straight or branched alkyl or O—(C1–C4)-straight or branched alkenyl, (C1-C6)-straight or branched alkyl or (C1-C6)-straight or branched alkenyl, (C5–C7)-cycloalkyl, (C5–C7)-cycloalkenyl substituted with (C1–C4)-straight or branched alkyl or (C1–C4)-straight or branched alkenyl, [(C1–C4)-alkyl or (C1–C4)-alkenyl]-Ar or Ar (Ar as described above); wherein J is hydrogen or C1 or C2 alkyl or benzyl; K is (C1–C4)-straight or branched alkyl, benzyl or cyclohexylethyl; or wherein J and K may be taken together to form a 5 membered heterocyclic ring which may contain an oxygen (O), sulfur (S), SO or SO wherein n is 0–3.