Patent ID: 8895010
Filing Date: 2014-11-25
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody polypeptide comprising a first variable domain that specifically binds human CD40L, wherein CD40L comprises the amino acid sequence of SEQ ID NO: 1, wherein the amino acid sequence of the first variable domain comprises (a) a CDR1 region of BMS2h-572-633 comprising SEQ ID NO: 2, (b) a CDR2 region of BMS2h-572-633 comprising SEQ ID NO: 3, (c) a CDR3 region of BMS2h-572-633 comprising SEQ ID NO: 4, (d) a FR1 region of BMS2h-572-633 comprising SEQ ID NO: 5, (e) a FR2 region of BMS2h-572-633 comprising SEQ ID NO: 6, (f) a FR3 region of BMS2h-572-633 comprising SEQ ID NO: 7, and (g) a FR4 region of BMS2h-572-633 comprising SEQ ID NO: 8; and wherein the antibody polypeptide inhibits binding of CD40L to CD40 with an EC50 of 100 pM to 100 nM.