Patent ID: 9035059
Filing Date: 2015-05-19
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein Ring A represents a partially saturated heteroaryl group which may be substituted by 1 or 2 substituents, which may be the same or different, selected from the group consisting of: an aryl group or a heteroaryl group, which aryl group and heteroaryl group may be each substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of (i) to (vii) below: R a C a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR W represents a single bond or either a C a C Ring B represents a C a partially saturated heteroaryl group which may be substituted by 1 or 2 halogen atoms, a saturated heterocyclyl group, an aryl group or a heteroaryl group, which aryl group and heteroaryl group may be each substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of: R a halogen atom, a C an aryl group, or a heteroaryl group, R Y represents a nitrogen atom or the formula N R m represents an integer of 0 or 1, and n is 0 provided that the following compounds are excluded: 2-(4-fluorobenzoyl)—N—(thiazol-2-yl)isoindoline-5-sulfonamide, 2-(2-(1H-indo1-1-yl)propanoyl)—N—(thiazol-2-yl)isoindoline-5-sulfonamide, 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)acetyl)—N—(pyrimidin-4-yl)isoindoline-5-sulfonamide, 2-(2-(7-chloro-1H-indol-yl)acetyl)—N—(pyrimidin-4-yl)isoindoline-5-sulfonamide, 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)—N—(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, (R)—N—(6-chloropyridazin-3-yl)-2-(2-(4-fluoro-1H-indo1-1-yl)propanoyl)isoindoline-5-sulfonamide, (R)-2-(2-(4-fluoro-1H-indo1-1-yl)propanoyl)—N—(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, (S)-2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)—N—(5-methyl-1,3,4-thiadiazol-2-yl)isoindoline-5-sulfonamide, (R)—N—(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-(4-fluoro-1H-indol-yl)propanoyl)isoindoline-5-sulfonamide, 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)acetyl)—N—(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, (S)-2-(2-(4-fluoro-1H-indo1-1-yl)propanoyl)—N—(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, 2-(3-(5-chloro-1H-indo1-1-yl)propanoyl)—N—(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)isoindoline-5-sulfonamide, (S)-2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(6-chloropyridazin-3-yl)isoindoline-5-sulfonamide, (S)-2-(2-(1H-indo1-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, 2-(3-(5-chloro-1H-indo1-1-yl)propanoyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide, 2-(2-(4-methoxyphenyl)acetyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide, (S)-2-(2-(4-fluoro-1H-indo1-1-yl)propanoyl)-N-(pyrimidin -4-yl)isoindoline-5-sulfonamide, (R)-2-(2-(1H-indo1-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide, 2-(2-(7-chloro-1H-indo1-1-yl)acetyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, 2-(2,4-difluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, 2-(2,5-difluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, 2-(4-fluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, 2-(3-(5-chloro-1H-indo1-1-yl)propanoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, 2-(2-fluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline -7-sulfonamide, 2-(2,4-dichlorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, and 2-(4-methoxybenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline -7-sulfonamide.