Patent ID: 8420123
Filing Date: 2013-04-16
Classification: A61J,A61K,A61P,B82Y,C07C,Y10S

Abstract:
1. A method of preparing a plurality of therapeutic nanoparticles, comprising: combining a therapeutic agent, a first polymer, and optionally a second polymer, with an organic solvent to form a first organic phase having about 5 to about 50% solids; combining the first organic phase with a first aqueous solution to form a second phase; emulsifying the second phase to form an emulsion phase; quenching the emulsion phase to form a quenched phase; adding a drug solubilizer to the quenched phase to form a solubilized phase of unencapsulated therapeutic agent; and sterile filtering the solubilized phase to recover the therapeutic nanoparticles, thereby forming a slurry of therapeutic nanoparticles having a diameter of about 80 nm to about 150 nm.