Patent ID: 6645518
Filing Date: 2003-11-11
Classification: A61L,A61P,Y10S

Abstract:
A method of maintaining cerebrovascular tone within the body of a patient, comprising:providing a medical device configured to be implanted within the vasculature of a patient; coating the medical device having a coating comprising: nitric oxide associated with and releasable from a polyurea network formed from a reaction on the medical device, the reaction comprising a mixture of: (a) a polyisocyanate; (b) an amine donor; (c) an isocyanatosilane adduct having at least one terminal isocyanate group and at least one hydrolyzable alkoxy group bonded to silicon; and optionally (d) a polymer selected from the group consisting of a polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid; and implanting the coated medical device within the vasculature of the patient.