Patent ID: 8445477
Filing Date: 2013-05-21
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) wherein Y and Z are independently selected from a) or b) such that one of Y and Z is selected from group a) and the other is selected from group b); Group a) is i) substituted C ii) C iii) trifluoromethyl; or iv) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, isoxazolyl, imidazolyl, furazan-3-yl, benzothienyl, thieno[3,2-b]thiophen-2-yl, pyrazolyl, triazolyl, tetrazolyl, and [1,2,3]thiadiazolyl; wherein C Group b) is i) C ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, indazolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo[1,2-a]pyridin-2-yl, furo[2,3-b]pyridinyl, furazan-3-yl, pyrrolo[2,3-b]pyridinyl, pyrrolo[3,2-b]pyridinyl, thieno[2,3-b]pyridinyl, quinolinyl, quinazolinyl, thienyl, and benzimidazolyl; iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, thienyl, bromo, and C iv) phenoxathiinyl; v) 10-oxidophenoxathiin-2-yl; vi) fluoren-9-one-2-yl; vii) 9,9-dimethyl-9H-fluorenyl; viii) 1-chloro-naphtho[2,1-b]thiophen-2-yl; ix) xanthen-9-one-3-yl; x) 9-methyl-9H-carbazol-3-yl; xi) 6,7,8,9-tetrahydro-5H-carbazol-3-yl; xii) 3-methyl-6,7-dihydro-5H-1-thia-4a,8-diaza-s-indacen-4-one-2-yl; xiii) 3-methyl-2-phenyl-4-oxo-chromen-8-yl; xiv) 1,3-dihydro-benzimidazol-2-one-5-yl optionally substituted with 1-phenyl, 1-(2,2,2-trifluoroethyl), 1-(3,3,3-trifluoropropyl), or 1-(4,4-difluorocyclohexyl), wherein 1-phenyl is optionally substituted with one to two fluoro substituents or trifluoromethyl; or xv) 4-(3-chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl; wherein C i) C ii) C iii) C iv) 4,4-difluorocyclohexylcarbonyl; v) C vi) 2-methoxy-ethoxy; vii) C viii) trifluoromethyl; ix) 2,2,2-trifluoroethyl; x) 2,2-difluoroethyl; xi) 3,3,3-trifluoropropyl; xii) trifluoromethoxy; xiii) 2,2,2-trifluoroethoxy-methyl; xiv) 2,2,2-trifluoroethoxy; xv) trifluoromethylthio; xvi) di(C xvii) N-phenyl-N-methylaminosulfonyl; xviii) piperidin-1-ylsulfonyl; xix) chloro; xx) cyano; xxi) hydroxy; xxii) fluoro; xxiii) bromo; xxiv) iodo; xxv) NR wherein C or R xxvi) (1-R xxvii) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C xxviii) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C xxix) pyridinylcarbonyl optionally substituted with a chloro substituent; xxx) phenylcarbonyl; xxxi) N-phenyl-N-methylaminosulfonyl; xxxii) piperidin-1-ylsulfonyl; xv) phenylsulfonyl optionally substituted with C xxxiii) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C xxxiv) phenylthio optionally substituted with C xxxv) C xxxvi) C xxxvii) ethylaminocarbonyl-methoxy; xxxviii) 2-methylcarbonylamino-ethoxy; xxxix) C xl) 2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl; with the proviso that not more than one substituent on C s is 0, 1 or 2; provided that when s is 2, R when s is 1, R with the proviso that a heteroaryl of Group b) is substituted with other than C with the proviso that when phenyl of Group b) is para-substituted with NR and, with the proviso that when R with the proviso that a compound of formula (I) is other than a compound wherein Y is thiazol-4-yl, Z is 2-hydroxy-3-methylcarbonylamino-phenyl, and s is 0; a compound wherein Y is 2-methoxyphenyl, Z is 4-cyclohexylphenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is thiazol-2-yl, s is 1, and R a compound wherein Y is thiazol-4-yl, Z is 2-methyl-1-(4,4-difluorocyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is 3-methyl-2-phenyl-chromen-4-one-8-yl, Z is thiazol-4-yl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-fluoro-3H-benzimidazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-fluoro-1H-benzimidazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-chloro-benzofuran-2-yl, and s is 0; a compound wherein Y is isothiazol-5-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-trifluoromethyl-furo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-bromo-furo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is 5-bromo-furo[2,3-b]pyridin-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-bromo-7-methyl-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 8-bromo-6-chloro-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is thiazol-4-yl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is thiazol-4-yl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is thiazol-2-yl, s is 1, and R a compound wherein Y is thiazol-4-yl, Z is 2-hydroxy-3-methylcarbonylamino-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(3-trifluoromethylphenylsulfonyl)phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 6-(2-chlorophenyloxy)pyridin-3-yl, and s is 0; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.