Patent ID: 6756052
Filing Date: 2004-06-29
Classification: A61K,Y10S

Abstract:
A device having a layered construction for transdermal administration of at least one active substance to a subject, said device comprising:(a) a first layer comprising at least one active substance selected from the group consisting of pharmaceutically and cosmetically active substances, and (b) a second layer comprising at least one component that causes an increase in local temperature and/or blood circulation in the skin where said component is rubefacient which comprises pelargonic acid vanillyl amide, cayenne pepper oil resin, capsicum fruit extract, tincture of capsicum extract, cayenne pepper, or a combination of the foregoing, wherein the device contains an amount of said component effective to increase the rate of penetration of active substance(s) into the skin, the movement of active substance(s) through the skin and/or the transdermal absorption rate of said active substance(s) applied to the skin and wherein the first layer is spacially separated from the second layer.