Patent ID: 8420670
Filing Date: 2013-04-16
Classification: A61P,C07D

Abstract:
1. A 4-Benzylaminoquinoline of formula (I) wherein R R R R R R R R or a physiologically tolerated salt thereof, provided that the following compounds and the physiologically tolerated salts thereof are excluded: a) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, 1,1-dimethylethyl ester b) 2-methyl-N-[[2′-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-4-quinolinamine, c) 2-methyl-N-[[3′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-4-quinolinamine, d) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, e) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-3-carboxylic acid, 1,1-dimethylethyl ester f) 2-methyl-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-4-quinolinamine, g) 4′-[[(8-methoxy-2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, h) 8-methoxy-2-methyl-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-4-quinolinamine, i) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-N-(methylsulfonyl)-[1,1′-biphenyl]-2-carboxamide, j) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, k) 4′-[[(2-methyl-4-quinolinyl)amino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, methyl ester l) N-[(2-methylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, m) N-[(2-methoxyphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, n) N-[(2-ethylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, o) N-[(2-bromophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, p) N-[(2,6-dichlorophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, q) N-[(2,6-dimethoxyphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, r) N-[(2,6-dimethylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, s) N-[(2,3-dimethylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, t) N-[(2,4-dimethylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, u) N-[(2,5-dimethylphenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, v) N-[(2-chlorophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, w) N-[(2-fluorophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, x) N-[(2-chloro-6-fluorophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, y) N-[(2,6-difluorophenyl)methyl]-8-methoxy-2-methyl-4-quinolinamine, z) N-[[2-(trifluoromethyl)phenyl]methyl]-8-methoxy-2-methyl-4-quinolinamine, aa) 4-[[(8-methoxy-2-methyl-4-quinolinyl)amino]methyl]-3-methyl-phenol, ab) 4-[(p-chlorobenzyl)amino]-quinaldine, ac) N-[(1S)-1-phenylethyl]-2-methyl-4-quinolinamine, ad) N-(phenylmethyl)-2-methyl-4-quinolinamine, ae) 4-[[1-(3,4-dimethoxyphenyl)hexyl]amino]-2-methyl-8-quinolinol, af) 4-[[1-(2-hexyl-4,5-dimethoxyphenyl)ethyl]amino]-2-methyl-8-quinolinol, ag) 4-[[1-(3,4-dimethoxyphenyl)hexyl]amino]-2-methyl-8-quinolinol, ah) 4-[[1-(2-hexyl-4,5-dimethoxyphenyl)ethyl]amino]-2-methyl-4-quinolinol, ai) N-[1-(3,4-dimethoxyphenyl)hexyl]-8-methoxy-2-methyl-4-quinolinamine, or aj) N-[1-(2-hexyl-4,5-dimethoxyphenyl)ethyl]-8-methoxy-2-methyl-4-quinolinamine.