Patent ID: 8314124
Filing Date: 2012-11-20
Classification: A61K,C07D

Abstract:
1. A process for the preparation of a crystalline salt of formula (II) wherein n is an integer of 2 or 3; A R is a straight or branched C R5 is a straight or branched, saturated or unsaturated C R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; R′ is hydrogen, a straight or branched, saturated or unsaturated C R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; comprising: reacting a 3-quinolinecarboxamide derivative in neutral form or as a monovalent metal salt, with a salt containing the multivalent metal cation in a liquid phase consisting of water and at least one water miscible organic solvent, in which liquid phase the salt of formula (II) is sparingly soluble.