Patent ID: 6420343
Filing Date: 2002-07-16
Classification: A61P,C07H

Abstract:
A compound of the formula or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: X1 is â€”CH2â€” or â€”NR4â€”; X2 is &boxH;O or &boxH;NOR1; Z is H, C1-C14 alkyl, (C6-C10 aryl)(C1-C10 alkyl)- or (4-10 membered heterocyclic)(C1-C10 alkyl)-, wherein one or two carbon atoms of the foregoing alkyl moieties are optionally replaced by a heteroatom selected from the group consisting of O, S and â€”N(R4)-, and the foregoing groups, except H, are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, hydroxy, C1-C14 alkoxy, C1-C14 alkyl, (C6-C10 aryl)(C1-C10 alkoxy)- and (4-10 membered heterocyclic)(C1-C10 alkoxy)-; R1 is H, methyl or ethyl; R2 is a group of the formula wherein n is an integer from 1 to 4; R3 is C6-C10 aryl or 4-10 membered heterocyclic, wherein said R3 is optionally substituted by 1 to 3 substituents independently selected from the group consisting of C1-C6 alkoxy, trifluoromethyl, trifluoromethoxy, halo, and â€”NR4R5; each R4 and R5 is independently selected from the group consisting of H and C1-C6 alkyl; R6 is H or acetyl; and, R7 and R8 are each independently selected from the group consisting of H and C1-C6 alkyl except that at least one of R7 and R8 is C1-C6 alkyl.