Patent ID: 7837881
Filing Date: 2010-11-23
Classification: B01D,G01N

Abstract:
1. A process for purification of a multi-component mixture (F) by means of at least six individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), wherein the multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and wherein columns, grouped into at least four sections (α,β,γ,δ), are run as follows: operating a first section (α) with at least one column in a batch mode position, wherein said first section (α) is provided with at least one inlet for solvent (s) and at least one outlet for purified intermediate product (B), such that said first section (α) washes the purified intermediate product (B) out of the system, but keeps the heavy impurities (C) inside the section (α), operating a second section (β) with at least one column, in an interconnected-mode position, wherein said second section (β) is provided with at least one inlet for solvent (s) and at least one outlet connected to an inlet of a second sub-section (δ operating a third section (γ) with at least one column, in a batch mode position wherein said third section (γ) is provided with at least one inlet for solvent (s) and an outlet for heavy impurities (C), such that said third section (γ) washes the heavy impurities (C) through said outlet out of the system and cleans the chromatographic column(s) of said third section (γ), operating a first sub-section (δ operating a second sub-section (δ operating a third sub-section (δ wherein the functions of the sections (α,β,γ,δ) and of the of the sub-sections (δ wherein, after or within a switch time (t*), the columns are moved in their positions in a counter direction to the general direction of flow of the solvent, in that: