Patent ID: 9006196
Filing Date: 2015-04-14
Classification: A61P,C07H,C12N

Abstract:
1. A double-stranded RNA compound having the structure: 5′ AGUAGUUUCCAUAGGUCUG-Z 3′ (antisense strand) (SEQ ID NO:28) 3′ Z′-UCAUCAAAGGUAUCCAGAC 5′ (sense strand) (SEQ ID NO: 5); wherein each A, U, C and G is an unmodified ribonucleotide or a 2′-O-Methyl sugar modified ribonucleotide; wherein each consecutive ribonucleotide is joined to the next ribonucleotide by a covalent bond; and wherein each of Z and Z′ is present or absent, if present is dTdT and is covalently attached at the 3′ terminus of the strand in which it is present; or a pharmaceutically acceptable salt such RNA compound.