Patent ID: 6057337
Filing Date: 2000-05-02
Classification: C07D

Abstract:
A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): ##STR117## wherein each of A and B is R.sup.1 or --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, wherein when A is R.sup.1, B is --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 and when A is --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, B is R.sup.1 ;Y is --CO--, --CONR.sup.5 -- or --COO--;Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --;R.sup.1 is an alkyl group of C.sub.10-30 ;R.sup.2 and R.sup.3 individually represent a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, or together represent a heterocycle having 3-7 members;wherein when --(Y).sub.1 --A is --CONR.sup.5 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, or when --Z--B is --OCONR.sup.6 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, said --NR.sup.5 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 of --(Y).sub.1 --A and said --NR.sup.6 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 of --Z--B may be expressed by the following Group W: ##STR118## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group;R.sup.4 is selected from the group consisting of a hydrogen atom, a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylamino group, a lower acylamino group, a lower alkoxy group and a lower acyloxy group;R.sup.5 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group; wherein when --(Y).sub.1 --A is --CONR.sup.5 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, --(Y).sub.1 --A may be --CO--W;R.sup.6 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group; wherein when --Z--B is --OCONR.sup.6 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, --Z--B may be --OCO--W or said Group W;l is 0 or 1;m is an integer of 2-5; andn is an integer of 0-5.