Patent ID: 6509021
Filing Date: 2003-01-21
Classification: A61K,A61Q,C12N

Abstract:
A cosmetic composition comprising:(a) at least one mutant Bacillus lentus alkaline protease, wherein the mutant protease comprises a Bacillus lentus alkaline protease having one or more amino acid substitutions in its amino acid sequence, wherein at least one of the substitutions is at a position selected from 99, 154, or 211 or combinations thereof relative to the unmodified Bacillus lentus alkaline protease, leads to a reduced positive charge or an increased negative charge, and results in the mutant protease having reduced tissue surface irritation relative to the modified or unmodified Bacillus lentus alkaline protease not having these substitutions; and (b) one or more cosmetic materials compatible with said mutant protease.