Patent ID: 9140712
Filing Date: 2015-09-22
Classification: A61B,A61K,G01N,G16H,G16Z

Abstract:
1. A method for determining ROX and BOX, comprising the steps of: providing a first sensor and a second sensor; providing a sample including an amount of bodily material, said sample including molecular oxygen and nitric oxide, wherein said first sensor is adapted to sense said molecular oxygen and to send a signal related to the amount of said molecular oxygen, and wherein said second sensor is adapted to sense said molecular oxygen and said nitric oxide and to send a signal related to the amount of said molecular oxygen and said nitric oxide; providing a processor in electrical connection with said first and second sensors and responsive to said signals received from said first and second sensors, and wherein said processor is adapted to determine the amount of said molecular oxygen and said nitric oxide from the difference between said first sensor signal and said second sensor signal; sensing by said first sensor molecular oxygen and by said second sensor molecular oxygen and nitric oxide present in said sample; then sending by said first and second sensors a first set of signals to said processor at a first point in time; determining by said processor from said first set of signals baseline values for said molecular oxygen and nitric oxide; introducing a first stress into said sample, wherein said first stress is a stress that is administered over time; then sensing over time with said first and second sensors said molecular oxygen and said nitric oxide present in said stressed sample; then sending by said first and second sensors a second set of signals to said processor at a second point in time; then sending by said first and second sensors a third set of signals to said processor at third point in time; determining by said processor from said second set of signals BOX values for said molecular oxygen and said nitric oxide, which are a measurement of a decrease in said molecular oxygen and said nitric oxide in said sample as compared to said baseline values; and determining by said processor from said third set of signals ROX values for said molecular oxygen and said nitric oxide, which are a measurement of an increase in said molecular oxygen and said nitric oxide in said sample as compared to said BOX values, respectively, wherein said increase in said nitric oxide is determined from the difference in said first sensor signal and said second sensor signal; introducing a second stress into said stressed sample; then sensing over time with said first and second sensors said molecular oxygen and said nitric oxygen; then sending by said first and second sensors a fourth set of signals to said processor at a fourth point in time; determining a SOX value, which is a sharp increase in either said molecular oxygen or said nitric oxide following said introduction of said second stress in said stressed sample as compared to said ROX value for said molecular oxygen and said nitric oxide, respectively; and administering said sample to a subject following said determination of said SOX value.