Patent ID: 7202247
Filing Date: 2007-04-10
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or its pharmaceutically acceptable salt or ester, wherein: R R R wherein one of R with the proviso that R R at least one of R 2α , R 3α , R 4α , R 5α , R 6α or one of R 2β , R 3β , R 4β , R 5β , R 6β must be selected from the group consisting of carboxy, carboxyalkoxy, cyano, tetrazol-5-yl, —C(O)OR 2 , —C(O)NHR 2 , —C(O)NH 2 , —C(O)N(R 2 ) 2 , —C(CH 3 ) 2 C(O)OH, —CH 2 C(O)OH, —NHR 2 , NH 2 , —NHSO 2 R 2 , N(R 2 ) 2 , —NR 2 SO 2 R 2 , —NHSO 2 NHR 2 , —NHC(O)R 2 , —NHC(O)OR 2 , —SCH 2 CO 2 H, —SCF 2 CO 2 H, —SH, —SR 2 , —NR 2 C(O)R 2 , —NHC(O)SR 2 , NHC(O)NHR 2 , —NHC(O)N(R 2 ) 2 , SC(R 1 ) 2 COOH, —SO 2 NH 2 , —SO 2 NHR 2 , —SO 2 N(R 2 ) 2 , and NR 7 R 7 wherein R 7 and R 7 are linked together forming a 4- to 7-membered ring that is either unsaturated, saturated, fully saturated or aryl optionally substituted with one or more selected from the group consisting of hydroxy, alkyl, carboxy, hydroxyalkyl, carboxyalkyl, amino, aminoalkyl, cyano, alkoxy, alkoxycarbonyl, acyl, oxo, and halo.