Patent ID: 6709824
Filing Date: 2004-03-23
Classification: B01J,C07C,C40B,Y02P

Abstract:
A library of compounds, and the individual compounds thereof, having the following structure: whereinB represents phenyl; C1, C2 and C3 each represent chiral carbon atoms; X represents O, S or NH; J represents â€”N(H)â€”Yâ€”N(H)â€”, wherein Y is â€”C(O)â€”or â€”C(S)â€”; R103 represents â€”OH or â€”SH; R104 represents a sterically bulky, aliphatic or cycloaliphatic substituent of up to 20 carbons; R105 is absent, or represents one or more additional substituents of B selected from the group consisting of alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or â€”(CH2)mâ€”R80; R106 and R107 each independently represent alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or â€”(CH2)mâ€”R80, or R106 and R107 taken together with C2 and C3 form a ring having from 4 to 8 atoms in the ring; R108 represents alkyl, alkenyl, alkynyl, acyl, thioacyl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, amidine, acetal, ketal, aryl, heteroaryl, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea, thiourea, or â€”(CH2)mâ€”R80; R109 is a solid support; R80 represents an unsubstituted or substituted aryl, a cycloalkyl, a cycloalkenyl, a heterocycle, or a polycycle; and m is an integer in the range 0 to 8 inclusive.