Patent ID: 7803557
Filing Date: 2010-09-28
Classification: A61P,G01N

Abstract:
1. A method for screening a candidate substance for anti-inflammatory activity, comprising: contacting a cell that expresses a Reso E receptor with the candidate substance, wherein the Reso E receptor is a murine Reso E receptor according to SEQ. ID NO: 2, a rat Reso E receptor according to SEQ. ID NO: 3 or human Reso ER1 according to SEQ. ID NO: 1; and detecting a biological activity mediated by the Reso E receptor wherein contacting the cell comprises administering the candidate substance to an animal in vivo, and the biological activity is reduced expression of IL-12 and reduced migration of dendritic cells into T-cell areas of a spleen relative to an animal not administered the candidate substance.