Patent ID: 7009057
Filing Date: 2006-03-07
Classification: A61P,C07D,Y02P

Abstract:
1. A method for obtaining the antidiabetic of formula I comprising condensing a compound of formula III where Z is a leaving group with a compound of formula II where R  to form an ether of formula IV: removing protecting group R converting the aniline of formula V to a diazonium salt, reacting the diazonium salt with an olefin of formula VI where R reacting the alkyl halide of formula VII with thiourea to form an imine of formula VIII: and, hydrolyzing the imine of formula VIII to give the antidiabetic of formula I; wherein the leaving group Z is a radical of the formula  wherein A, which may be substituted or unsubstituted, is an aryl or an alkyl group; wherein M is hydrogen or an alkali metal; wherein the protecting group R wherein m is 0 or 1; wherein when m=1, R=Br;  wherein the electron withdrawing group R and wherein X is a halogen atom.