Patent ID: 8580798
Filing Date: 2013-11-12
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), a salt thereof, an oxidized derivative thereof, wherein one or more of the nitrogens are substituted with a hydroxy group, or a diastereoisomeric form thereof, either as an isolated stereoisomer or in a mixture of stereoisomers wherein A is pyrimidine, optionally substituted with 1 to 3 substituents which are independently R B is phenyl, naphthyl, or pyridyl, optionally substituted with 1 to 4 substituents which are independently C L is a bridging group which is: (a) —(CH (b) —(CH (c) —(CH (d) —(CH (e) —(CH (f) —(CH (g) —(CH M is a pyridine or pyrimidine ring, optionally substituted with 1-3 substituents which are independently selected from: (1) C (2) C (3) C (4) hydroxy; (5) amino; (6) C (7) C (8) halogen; (9) nitro; (10) C(O) NR (11) C(O)OR (12) C(O)R (13) CN; (14) C(S)NR (15a) C(O)NR (15b) C(O)NR (16) tetrazolyl; (17) imidazolyl; (18) imidazoline-2-yl; (19) 1,3,4-oxadiazoline-2-yl; (20) 1,3-thiazoline-2-yl; (21) 5-thioxo-4,5-dihydro-1,3,4-thiazoline-2-yl; (22) 5-oxo-4,5-dihydro-1,3,4-oxadiazoline-2-yl; or (23) a group of the formula each of R R R R R