Patent ID: 6689806
Filing Date: 2004-02-10
Classification: C07D

Abstract:
A compound of formula II: or a pharmaceutically acceptable salt thereof wherein,P is 0; M, Q, U, and V are independently selected from the group consisting of carbon, nitrogen, oxygen and sulfur, it being understood that, when M, Q, U, or V is oxygen or sulfur or nitrogen (wherein said nitrogen is participating in a double bond), R20, R21, R23, or R24, respectively, do not exist; R16, R17, R18, R19, and R20 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, mercapto, alkylthio, aryloxy, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, carbonyl, C-carboxy, O-carboxy, carboxyalkyl, cyano, nitro, halo, O-carbamyl, N-carbamyl, C-amido, N-amido and â€”NR25R26; R21, R23, and R24 are independently selected from the group consisting of halo, hydroxy, â€”NR25R26, lower alkyl optionally substituted with one or more groups selected from the group consisting of hydroxy, one or more halo groups, C-carboxy, C-amido, heteroalicyclic and â€”NR25R26, cycloalkyl, lower alkoxy optionally substituted with one or more halo groups, aryl, â€”NR25R26 and heteroaryl, aryl optionally substituted with one or more groups selected from the group consisting of halo, hydroxy, lower alkoxy, â€”NR25R26 and C-carboxy; and, R25 and R26 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, carbonyl, sulfonyl, and, when combined may form a five-member or a six-member heteroalicyclic ring.