Patent ID: 8575167
Filing Date: 2013-11-05
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula (I) wherein R is (1) a cyclic group selected from the group consisting of: (2) a carbamoyl group optionally substituted by 1 or 2 substituent(s) selected from the group consisting of: provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group; ring A is a pyridazine ring optionally substituted by 1 or 2 substituent(s) selected from the following Substituent Group (a); R (1) a hydrogen atom, (2) an optionally substituted hydrocarbon group, (3) an optionally substituted heterocyclic group, (4) a hydroxyl group optionally substituted by a substituent selected from the group consisting of: (5) an amino group optionally mono- or di-substituted by substituent(s) selected from the group consisting of: (6) a mercapto group optionally substituted by a substituent selected from the group consisting of: (7) a cyano group, (8) a nitro group, (9) an acyl group, or (10) a halogen atom, or R m and n are each independently an integer of 0 to 2; and ring B is a ring selected from the group consisting of: wherein Substituent Group (a) is: (1) a halogen atom, (2) a C (3) a C (4) a C (5) a C (6) a C (7) a C (8) a C (9) a C (10) a formyl group or a C (11) a C (12) a formyloxy group or a C (13) a C (14) a carboxy group, (15) a C (16) a C (17) a carbamoyl group, (18) a mono-C (19) a di-C (20) a mono-, di- or tri-halogeno-C (21) an oxo group, (22) an amidino group, (23) an imino group, (24) an amino group, (25) a mono-C (26) a di-C (27) a 3- to 8-membered aromatic heterocyclic group containing, besides carbon atom(s) and one nitrogen atom, 1 to 3 heteroatom(s) selected from the group consisting of nitrogen atom(s), oxygen atom(s) and sulfur atom(s), (28) a 3- to 8-membered non-aromatic heterocyclic group containing, besides carbon atom(s) and one nitrogen atom, 1 to 3 heteroatom(s) selected from the group consisting of nitrogen atom(s), oxygen atom(s) and sulfur atom(s), (29) a C (30) a hydroxy group, (31) a nitro group, (32) a cyano group, (33) a mercapto group, (34) a sulfo group, (35) a sulfino group, (36) a phosphono group, (37) a sulfamoyl group, (38) a mono-C (39) a di-C (40) a C (41) a C (42) a C (43) a C (44) a C (45) a C wherein: (A) all of the “acyl group” recited above are a group represented by a formula selected from the group consisting of —COR (B) all of the “optionally substituted hydrocarbon group” recited above are a hydrocarbon group selected from the group consisting of: (C) all of the “optionally substituted heterocyclic group” recited above are a heterocyclic group selected from the group consisting of an aromatic heterocyclic group and a non-aromatic heterocyclic group, wherein each of the aromatic heterocyclic group and the non-aromatic heterocyclic group is optionally substituted by 1 to 5 substituent(s) selected from the Substituent Group (a); or a salt or a prodrug thereof.