Patent ID: 7968588
Filing Date: 2011-06-28
Classification: A61K,A61P

Abstract:
1. A concentrated formulation comprising the antibiotic WAP-8294A 2 of the following structural formula (1): as an active ingredient, in a concentration of 5-20 mg/mL, and further comprising 2-hydroxypropyl-β-cyclodextrin, in an aqueous medium suitable for injection, said formulation being in the form of a concentrated, stable aqueous solution of low pH ranging between 2 and 4, said 2-hydroxypropyl-β-cyclodextrin being present in an amount of 5-50% which is effective to render the WAP-8294A 2 safe in terms of hematology and toxicology upon adjustment of pH and dilution of said concentrated aqueous solution with a solution suitable for intravenous injection or infusion.