Patent ID: 6340455
Filing Date: 2002-01-22
Classification: A61K,Y10S

Abstract:
A method for determination of predisposition of an individual to develop marginal periodontitis comprising:a) performing a screening test on said individual with a first reagent comprising a surface structure common to anaerobic Gram negative pathogens to elicit a reaction in the individual, wherein the first reagent is capable of triggering an inflammatory response associated with periodontitis and gingivitis in the individual; and b) evaluating the reaction, lack of reaction or minor reaction of the individual to the first reagent of the screening test, indicating the predisposition of the individual to develop marginal periodontitis; wherein step a) is accompanied by challenge with a negative control to confirm negative reaction; wherein said first reagent comprises a structure selected from a non-carbohydrate entity of surface lipo- or proteoconjugates of said pathogens, wherein a second reagent is an agonist capable of producing an inflammatory response on challenge of said individual to confirm positive reaction selected from histamine, serotonin, prostaglandins, leukotrienes and bradykinin, and wherein said negative control is pyrogene free water; and wherein said first reagent comprises Lipid A in a concentration within the range about 0.05 to about 2 mg/ml.