Patent ID: 6262036
Filing Date: 2001-07-17
Classification: A61K,C07H,C12N

Abstract:
A method of inhibiting translation of a target ribonucleic acid sequence in a cell or multicellular organism comprising administering to said cell or organism an oligonucleoside compound comprising an RNase H-activating region and a non-RNase H activating region, whereinthe RNase H-activating region comprises a segment of at least three consecutive 2'-unsubstituted nucleosides linked by charged internucleoside linkage structures,the non-RNase H-activating region comprises a segment of at least two linked nucleosides, wherein at least one linkage in said non-RNase H-activating region is chirally selected,and wherein the base sequence of the oligonucleoside compound is complementary to a target region of the target ribonucleic acid sequence.