Patent ID: 8835571
Filing Date: 2014-09-16
Classification: A61K,A61P

Abstract:
1. A conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound, wherein the fatty acid derivative is represented by the formula (I): wherein L, M and N are hydrogen, hydroxy, halogen, straight or branched C1-6 alkyl, hydroxy(straight or branched C1-6)alkyl, straight or branched C1-6 alkanoyloxy or oxo, wherein at least one of L and M is a group other than hydrogen, and the double bond in the five-membered ring is optional; A is —CH B is single bond, —CH Z is  or single bond wherein R R Ra is a saturated or unsaturated straight or branched C1-14 aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, oxo, hydroxy, straight or branched C1-6 alkyl, straight or branched C1-6 alkoxy, straight or branched C1-6 alkanoyloxy, cyclo(straight or branched C3-6)alkyl, cyclo(straight or branched C3-6)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group; straight or branched C1-6 alkoxy; straight or branched C1-6 alkanoyloxy; cyclo(straight or branched C3-6)alkyl; cyclo(straight or branched C3-6)alkyloxy; aryl; aryloxy; heterocyclic group; heterocyclic-oxy group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; and provided that Z is C═O and/or B is —CH