Patent ID: 6114341
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
A pyrimido[1,2-a]indole compound of the formula (I): ##STR141## in which A, D, E, G, L and M are identical or different and represent hydrogen, halogen, trifluoromethyl, carboxyl, hydroxyl, straight-chain or branched alkoxy having 1 to 6 carbon atoms, straight-chain or branched alkoxycarbonyl having 2 to 6 carbon atoms, or straight-chain or branched alkyl having 1 to 6 carbon atoms, which alkyl is optionally substituted by hydroxyl or by straight-chain or branched alkoxy having 1 to 4 carbon atoms;R.sup.1 and R.sup.2 are identical or different and represent hydrogen, cycloalkyl having 3 to 8 carbon atoms, or straight-chain or branched alkyl having 1 to 10 carbon atoms, which alkyl is optionally substituted by cycloalkyl with 3 to 6 carbon atoms, or R.sup.1 and R.sup.2 represent phenyl which is optionally substituted by halogen or trifluoromethyl; orR.sup.1 and R.sup.2 together with the carbon atom to which they are bonded form a 4- to 8-membered cycloalkyl ring; andR.sup.3 represents phenyl which is optionally substituted 1 to 3 times, identically or differently, by nitro, carboxyl, halogen, cyano, straight-chain or branched alkenyl having 2 to 6 carbon atoms, alkoxycarbonyl having 2 to 6 carbon atoms, or straight-chain or branched alkyl having 1 to 6 carbon atoms, which alkyl is optionally substituted by hydroxyl, carboxyl, straight-chain or branched alkoxy having 1 to 6 carbon atoms, or straight-chain or branched alkoxycarbonyl having 2 to 6 carbon atoms, and/or said phenyl is optionally substituted by a group of the formula --OR.sup.4 or --NR.sup.5 R.sup.6 ;in whichR.sup.4 is hydrogen, straight-chain or branched alkyl having 1 to 6 carbon atoms, or straight-chain or branched alkenyl having 2 to 6 carbon atoms;R.sup.5 and R.sup.6 are identical or different and denote phenyl, hydrogen, straight-chain or branched alkyl having 1 to 6 carbon atoms, or straight-chain or branched acyl having 1 to 8 carbon atoms, which acyl is optionally substituted by a group of the formula --NR.sup.7 R.sup.8 ;in whichR.sup.7 and R.sup.8 are identical or different and denote hydrogen or straight-chain or branched acyl having 1 to 8 carbon atoms;optionally in the form of a purified stereoisomer thereof or a mixture of two or more stereoisomers thereof, or a salt of said compound, purified stereoisomer or stereoisomer mixture.