Patent ID: 8236507
Filing Date: 2012-08-07
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated polypeptide that binds to TRAF2, said polypeptide comprising: a) the amino acid sequence of SEQ ID NO:2, the amino acid sequence encoded by the nucleotide sequence of SEQ ID NO:3, or the amino acid sequence of SEQ ID NO:5; b) the amino acid sequence of a fragment of a), which fragment binds to TRAF2 and comprises a serine/threonine protein kinase motif of (a); c) the amino acid sequence of an analog of a), said analogue differing from a) by not more than five amino acid changes, each such change being a conservative substitution, which analog binds to TRAF2; or d) a derivative of a), b) or c) which binds to TRAF2, said derivative selected from the group consisting of glycosylation or phosphorylation of an amino acid side chain or an N- or C-terminal, aliphatic esters of the carboxyl groups, amides of the carboxyl groups by reaction with ammonia or with primary or secondary amines, N-acyl derivatives or free amino groups of the amino acid residues formed with acyl moieties and O-acyl derivatives of free hydroxyl group formed with acyl moieties.