Patent ID: 6294551
Filing Date: 2001-09-25
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR22##or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:A and B are taken together, with the nitrogen and carbon atoms to which they are respectively attached, to form a 5-7 membered saturated or unsaturated heterocyclic ring containing no further heteroatoms in addition to the nitrogen to which A is attached in any chemically stable oxidation state;X is either O or S;Y is a direct bond, a C.sub.1 -C.sub.6 straight or branched chain alkyl, or a C.sub.2 -C.sub.6 straight or branched chain alkenyl, wherein any of the carbon atoms of said alkyl or alkenyl are optionally substituted in one or more positions with amino, halo, haloalkyl, thiocarbonyl, ester, thioester, alkoxy, alkenoxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, sulfonyl, oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl are optionally replaced with O, NH, NR.sub.2, S, SO, or SO.sub.2, wherein R.sub.2 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)-straight or branched chain alkyl, and (C.sub.3 -C.sub.6)-straight or branched chain alkenyl or alkynyl;Z is a direct bond, or a C.sub.1 -C.sub.6 straight or branched chain alkyl, or a C.sub.2 -C.sub.6 straight or branched chain alkenyl, wherein any of the carbon atoms of said alkyl or alkenyl are optionally substituted in one or more positions with amino, halo, haloalkyl, thiocarbonyl, ester, thioester, alkoxy, alkenoxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, sulfonyl, oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl are optionally replaced with O, NH, NR.sub.2, S, SO, or SO.sub.2, wherein R.sub.2 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)-straight or branched chain alkyl, and (C.sub.3 -C.sub.6)-straight or branched chain alkenyl or alkynyl;C and D are independently:hydrogen, Ar, C.sub.1 -C.sub.6 straight or branched chain alkyl, or C.sub.2 -C.sub.6 straight or branched chain alkenyl, wherein any of the carbon atoms of said alkyl or alkenyl are optionally substituted in one or more position(s) with C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, hydroxyl, carbonyl oxygen, or Ar, wherein said alkyl, alkenyl, cycloalkyl or cycloalkenyl groups are optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, hydroxy, amino, halo, haloalkyl, thiocarbonyl, ester, thioester, alkoxy, alkenoxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, sulfonyl, wherein any of the carbon atoms of said alkyl or alkenyl are optionally substituted in one or more positions with oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl are optionally replaced with O, NH, NR.sub.2, S, SO, or SO.sub.2, wherein R.sub.2 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)-straight or branched chain alkyl, and (C.sub.3 -C.sub.6)-straight or branched chain alkenyl or alkynyl;wherein Ar is selected from the group consisting of a carbocyclic ring, quinoline, and isoquinoline; wherein said Ar group is substituted or unsubstituted; andR.sub.1 is selected from the group consisting of Ar, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, or C.sub.1 -C.sub.6 straight or branched chain alkyl or C.sub.2 -C.sub.6 straight or branched chain alkenyl which is substituted in one or more positions with Ar, amino, halo, haloalkyl, hydroxy, trifluoromethyl, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, carbonyl, thiocarbonyl, ester, thioester, alkoxy, alkenoxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, sulfonyl, substituted alkyl or alkenyl wherein any of the carbon atoms of the alkyl or alkenyl are optionally replaced with S, SO, SO.sub.2, O, or NR.sub.2 wherein R.sub.2 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)-straight or branched chain alkyl, and (C.sub.3 -C.sub.6)-straight or branched chain alkenyl or alkynyl.