Patent ID: 9040492
Filing Date: 2015-05-26
Classification: A61P,C12N

Abstract:
1. A double-stranded lipid-modified RNA comprising an antisense strand having a nucleotide sequence complementary to a target sequence in a target gene, and a sense strand having a nucleotide sequence complementary to the antisense strand, the double-stranded lipid modified RNA being capable of suppressing expression of the target gene, and the sense strand having a double-stranded lipid bound directly or via a linker to at least one of the first to sixth nucleotides from the 5′ end, wherein said RNA does not contain any other nucleotide modifications, and wherein said double-stranded lipid is a glycerophospholipid, and wherein said glycerophospholipid comprises two hydrophobic groups which each comprise a fatty acid residue.