Patent ID: 8969316
Filing Date: 2015-03-03
Classification: A61P,C12N,C12Y

Abstract:
1. A short antisense compound 8 to 14 monomers in length, comprising a 2′-deoxyribonucleotide gap region flanked on each side by a wing, wherein each wing independently comprises 1 to 3 high-affinity modified monomers, wherein the short antisense compound has a motif selected from the group consisting of 1-12-1, 1-1-10-2, 2-10-1-1, 2-10-2, 1-10-1, 1-10-2, 3-8-3, 2-8-2, 1-8-1, 3-6-3, and 1-6-1, and wherein the short antisense compound is targeted to a nucleic acid (SEQ ID NO: 10) encoding diacylglycerol O-acyltransferase 2 (DGAT2) in the liver.