Patent ID: 6645500
Filing Date: 2003-11-11
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
A method for in vivo down-regulation of osteoprotegerin ligand (OPGL) activity in an animal, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount ofat least one OPGL polypeptide or analogue thereof which has as a result that immunization of the animal with the OPGL polypeptide or analogue thereof induces production of antibodies against the animal's own OPGL polypeptide which down-regulates the animal's own OPGL activity, wherein said OPGL polypeptide or analogue thereof comprises the sequence of residues 159-317 of SEQ ID NO. 2, or the sequence of residues 159-317 of SEQ ID NO. 2 wherein at least one foreign promiscuous, immunodominant T helper lymphocyte epitope (TH), is introduced in said residues 159-317.