Patent ID: 7395160
Filing Date: 2008-07-01
Classification: C40B,G01N,G16B,Y10T

Abstract:
1. A method of determining whether mass spectral data from a test serum is acceptable for analysis in a bioassay, comprising: selecting a diverse group of sera, the diverse group of sera having different characteristics; diluting each serum of the diverse group of sera with a plurality of different diluents; obtaining information associated with a mass spectrum of each of the diluted sera from the diverse group of sera using an electrospray process; generating a control model based at least in part on the spectra obtained from the diverse group of sera, the control model including at least one centroid located in an n-dimensional space defined by n mass spectral features included in the control model; diluting a test serum with a test diluent; performing mass spectrometry on the test serum to obtain a test spectrum associated with the test serum; mapping the test spectrum to the n-dimensional space; and certifying that the test spectrum is acceptable for analysis in the bioassay if it is determined that the test spectrum maps to the n-dimensional space within an acceptable distance from said at least one centroid in the control model.