Patent ID: 8114899
Filing Date: 2012-02-14
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 7-Fluoro-2-(4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Fluoro-2-(4-fluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydro-chloride; 7-Chloro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 8-Methoxy-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 2-(4-Methylphenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-dimethylcarbamate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl morpholine-4-carboxylate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-dimethylcarbamate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl pyrrolidine-1-carboxylate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 2-Phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-(2-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-Ethyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-Ethyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-(2,2′,2″-Trifluoroethyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl pyrrolidine-1-carboxylate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl piperidine-1-carboxylate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl morpholine-4-carboxylate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-dimethylcarbamate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl pyrrolidine-1-carboxylate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl piperidine-1-carboxylate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl morpholine-4-carboxylate; 2-(4-Chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl 4-methylpiperazine-1-carboxylate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-dimethylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl 4-methylpiperazine-1-carboxylate; 2-Phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-dimethylcarbamate; 2-Phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 2-Phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 2-Phenyl-4,5-dihydro-2H-benzo[e]indazol-1-yl pyrrolidine-1-carboxylate; 7-Chloro-2-(4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(4-Fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-propylcarbamate; 2-(3-Chloro-4-methylphenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chloro-4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(2,4-difluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate: 2-(Pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-2-(pyridin-2-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Methoxy-2-(4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Bromo-2-(4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(3-chloro-4-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-methyl-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chlorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(4-Fluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(4-Fluorophenyl)-2H-benzo[e]indazol-1-yl N-methyl-N-propylcarbamate; 2-(3-Chloro-4-fluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 2-(3-Chloro-4-methylphenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(4-fluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(3-chloro-4-fluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(3-chloro-4-methylphenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(2,4-difluorophenyl)-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Methoxy-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Methyl-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-3-(pyridin-3-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-2-(pyridin-3-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Fluoro-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Fluoro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-3-(4-fluorophenyl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(pyridin-2-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-2-(3-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(3-fluorophenyl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Bromo-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Bromo-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-3-(4-methylphenyl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(4-methylphenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(2-fluorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(4-chlorophenyl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(4-chlorophenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-2-(4-methoxyphenyl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(4-methoxyphenyl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(3-fluorophenyl)-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate; 7-Chloro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate; 7-Chloro-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 7-Chloro-4,5-dihydro-3-(pyridin-4-yl)-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 6-Methoxy-3-(pyridin-4-yl)-4,5-di hydro-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; 7-Chloro-3-(pyridin-4-yl)-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl piperidine-1-carboxylate hydrochloride; 7-Chloro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl piperidine-1-carboxylate hydrochloride; 7-Chloro-2-(pyridin-3-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-3-(pyridin-3-yl)-4,5-di hydro-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-3-(pyridin-4-yl)-4,5-di hydro-3H-benzo[e]indazol-1-yl N,N-diisopropylthiocarbamate hydrochloride; 7-Chloro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl cis-2,6-dimethylpiperidine-1-carboxylate hydrochloride; 7-Chloro-2-(pyridin-4-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N-methyl-N-(tert-butyl)carbamate hydrochloride; 7-Chloro-3-(pyridin-3-yl)-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-3-(pyridin-2-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 7-Fluoro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-3-(pyrimidin-2-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 7-Chloro-2-(pyrazin-2-yl)-4,5-dihydro-2H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 7-Fluoro-3-(pyridin-4-yl)-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate hydrochloride; 7-Chloro-3-(pyridin-2-yl)-3H-benzo[e]indazol-1-yl N,N-diisopropylcarbamate; 7-Chloro-3-(pyridin-4-yl)-4,5-dihydro-3H-benzo[e]indazol-1-yl N-methyl-N-(tert-butyl)carbamate hydrochloride; 7-Chloro-3-(pyridin-4-yl)-3H-benzo[e]indazol-1-yl N,N-diethylcarbamate hydrochloride; and 7-Chloro-3-(pyridin-4-yl)-3H-benzo[e]indazol-1-yl N-methyl-N-phenylcarbamate hydro-chloride.