Patent ID: 9006449
Filing Date: 2015-04-14
Classification: A61P,C07B,C07C,C07D

Abstract:
1. A compound of Formula (I) or an enantiomer, a diastereomer, or a mixture thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein: E is —N(R3)-, —O—, or —S—, or is —X X (G) is an aryl or heterocyclyl group; each (R1) is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide hydroxyl, alkoxy, urea, carbamate, acyl, or carboxyl; each (R2) is independently chosen from —H, alkyl, alkenyl, alkynyl, cyclyi, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, or carboxyl, wherein each (R2) group has 1, 2, or 3 independently chosen optional substituents or two (R2) groups can be taken together to form a heterocyclyl or aryl group having 1, 2, or 3 independently chosen optional substituents, wherein said optional substituents are independently chosen from alkyl, alkanoyl, heteroalkyl, heterocyclyl, haloalkyl, cycloalkyl, carbocyclyl, arylalkoxy, heterocyclylalkoxy, aryl, aryloxy, heterocyclyloxy, alkoxy, haloalkoxy, oxo, acyloxy, carbonyl, carboxyl, carboxamido, cyano, halogen, hydroxyl, amino, aminoalkyl, amidoalkyl, amido, nitro, thiol, alkylthio, arylthio, sulfonamide, sulfinyl, sulfonyl, urea, or carbamate; R3 is —H or a (C each L1 is independently alkylene or heteroalkylene; and n is 0, 1, 2, 3, 4 or 5.