Patent ID: 8288570
Filing Date: 2012-10-16
Classification: A61P,C07C,C07D

Abstract:
1. A method for synthesizing 7-iodo sancycline, 7-iodo oxytetracycline, 7-iodo methacycline, 7-iodo doxycycline or 7-iodo tetracycline, comprising: treating unsubstituted sancycline, unsubstituted oxytetracycline, unsubstituted methacycline, unsubstituted doxycycline or unsubstituted tetracycline, respectively with at least one equivalent of N-iodosuccinimide in trifluoroacetic acid thereby synthesizing 7-iodo sancycline, 7-iodo oxytetracycline, 7-iodo methacycline, 7-iodo doxycycline or 7-iodo tetracycline.