Patent ID: 6143523
Filing Date: 2000-11-07
Classification: A61K,C07K,C12N,C40B,G01N,Y10S

Abstract:
A nucleic acid encoding a human growth hormone variant comprising a set of amino acid substitutions selected from the group consisting of:R167N, D171S, E174S, F176Y, I179T;R167E, D171S, E174S, F176Y;F10A, M14W, H18D, H21N;F10A, M14W, H18D, H21N, R167N, D171S, E174S, F176Y, I179T;F10A, M14W, H18D, H21N, R167N, D171A, E174S, F176Y, I179T;F10H, M14G, H18N, H21N;F10A, M14W, H18D, H21N, R167N, D171A, T175T, I179T; andF10I, M14Q, H18E, R167N, D171S, I179T.