Patent ID: 6057325
Filing Date: 2000-05-02
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR16## a N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, whereinAlk is C.sub.1-6 alkanediyl;R.sup.1 is hydrogen, C.sub.1-6 alkyl, aryl or arylC.sub.1-6 alkyl;R.sup.2, R.sup.3 and R.sup.4 are each independently selected from hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, C.sub.1-6 alkylthio, mercapto, amino, mono- and di(C.sub.1-6 alkyl)amino, carboxyl, C.sub.1-6 alkyloxycarbonyl or C.sub.1-6 alkylcarbonyl;R.sup.5 is hydrogen, C.sub.1-6 alkyl, phenyl or phenylC.sub.1-6 alkyl;R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, C.sub.1-6 alkylthio, or a radical of formula-NR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 are each independently selected from hydrogen, C.sub.1-6 alkyl, phenyl or phenylC.sub.1-6 alkyl;R.sup.7 is hydrogen or C.sub.1-6 alkyl; orR.sup.6 and R.sup.7 taken together may form a bivalent radical --R.sup.6 --R.sup.7 --,wherein --R.sup.6 --R.sup.7 --represents ##STR17## wherein one or two hydrogen atoms of said radicals (a-1) to (a-5) each independently may be replaced by halo, C.sub.1-6 alkyl, arylC.sub.1-6 alkyl, trifluoromethyl, amino, hydroxy, C.sub.1-6 alkyloxy or C.sub.1-10 alkylcarbonyloxy; or where possible, two geminal hydrogen atoms may be replaced by C.sub.1-6 alkylidene or arylC.sub.1-6 alkylidene; or--R.sup.6 --R.sup.7 --may also be ##STR18## wherein one or where possible two or three hydrogen atoms in said radicals (a-6) to (a-14) each independently may be replaced by C.sub.1-6 alkyl or aryl; andaryl is phenyl or phenyl substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, C.sub.1-6 alkylthio, mercapto, amino, mono- and di(C.sub.1-6 alkyl)amino, carboxyl, C.sub.1-6 alkyloxycarbonyl and C.sub.1-6 alkylcarbonyl.