Patent ID: 8222454
Filing Date: 2012-07-17
Classification: A61P,C07B,C07C

Abstract:
1. A process for preparing optically pure milnacipran and its pharmaceutically acceptable salts, comprising the steps of: adopting racemic milnacipran as a raw material; adopting at least one of a tartaric acid derivative or its composition as resolving agent; dissolving and mixing the raw material with the resolving agent in the molar ratio of 1:0.3-1.3 in ketone or alcohol solvent to produce a mixture; crystallizing the mixture under room temperature to precipitate diastereoisomer salt as a solid; filtering to obtain a resolved product; suspending the resolved product in organic solvent and water to produce a suspended mixture; adding alkali to the suspended mixture to separate out free alkali of optically pure milnacipran; and reacting the free alkali of optically pure milnacipran with an acid to obtain its corresponding salt.