Patent ID: 6413938
Filing Date: 2002-07-02
Classification: A61K,A61P,C07H,Y10S

Abstract:
A compound of formula (I): wherein:R1 is hydroxy; O-acetyl; or a halo atom; R2 is hydroxy; O-acetyl; or a halo atom; R3 is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl â€”NR8R9 (where R8 and R9 are the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC,1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); â€”OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14arylC2-6alkenyl or C6-14arylC2-6alkynyl); or â€”SR11 (where R11 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl); R4, R5, R6, and R7 , which are the same or different, are each independently selected from hydrogen; a halo atom; cyano; nitro; C6-14aryl; C6-14arylC1-8alkyl; â€”NR8R9 (where R8 and R9 are the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); â€”OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); â€”SR12 (where R12 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl); trifluoromethyl; â€”S(O)2R13 (where R13 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl); C(O)NR14R15 (where R14 and R15 are the same or different and are hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl); heterocycle or heterocycleC1-8alkyl; provided that when R5 and R6 are Cl, R4 and R7 are hydrogen and R3 is Cl or Br; then R1 and R2 are not hydroxy or O-acetyl;or a pharmaceutically acceptable derivative thereof.