Patent ID: 8372807
Filing Date: 2013-02-12
Classification: A61K,A61P

Abstract:
1. A method for decreasing uric acid levels in one or more tissues or organs of a subject, comprising administering to the subject a uric acid level decreasing amount of a compound of Formula (I): wherein wherein R R R wherein R provided that R b) (C c) Het optionally substituted with (C d) —SO e) —O—(C provided that the carbon atom of —O—(C f) —C(═O)N(R g) —NHC(═O)—R h) —NHSO i) —C≡C-R provided that the carbon atom of —O—(C wherein each of said Het and the Het portion of said —O-Het is optionally substituted with one or two substituents each independently selected from halo, oxo, (C and wherein R and wherein said (C or R wherein Het is a 4,5- or 6-membered heterocycle or a 9- or 10-membered heterobicycle, each of which is saturated, unsaturated or aromatic and each of which containing from one to four heteroatoms each independently selected from N, O and S, wherein each said N heteroatom is, independently and where possible, exist in an oxidized state such that it is further bonded to an O atom to form an N-oxide group and wherein each said S heteroatom is, independently and where possible, exist in an oxidized state such that it is further bonded to one or two oxygen atoms to form the groups SO or SO or a metabolite, pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof.