Patent ID: 6452000
Filing Date: 2002-09-17
Classification: A61P,C07D

Abstract:
A process for the preparation of a compound of formula (II): wherein:R1 is C1-C4 haloalkyl; R10 is C1-C10 alkyl, benzyl, naphthylmethyl, 3,4-methylenedioxybenzyl, or C1-C4 alkyl substituted with phenyl wherein said phenyl is substituted with 0-3 R10a; R10a is C1-C4 alkyl, C1-C4 alkoxy, halo or cyano; and G taken together along with the oxygen atoms to which G is attached forms a group selected from: â€”Oâ€”C(â€”CH2CH2CH2CH2CH2â€”)â€”Oâ€”, â€”Oâ€”C(CH2CH3)2â€”Oâ€”, â€”Oâ€”C(CH3)(CH2CH3)â€”Oâ€”, â€”Oâ€”C(CH2CH2CH2CH3)2â€”Oâ€”, â€”Oâ€”C(CH3)(CH2CH(CH3)CH3)â€”Oâ€”, â€”Oâ€”CH(phenyl)â€”Oâ€”, â€”OCH2Oâ€”, â€”OC(CH3)2Oâ€”, and â€”OC(OCH3)(CH2CH2CH3)Oâ€”; the process, comprising: (1B) contacting a compound of formula (XI): with a suitable base to form a compound of formula (II).