Patent ID: 6306595
Filing Date: 2001-10-23
Classification: C12Q,G16B,G16C

Abstract:
A method for designing molecules having altered biological activity comprising the steps of:designing molecules using a metabophore, wherein the metabophore is based on a pharmacophore of other molecules with similar biological activity, wherein the other molecules are oriented to have an optimal fit into nucleic acid sequences such that a low energy of interaction and optimal steric fit are obtained, wherein the metabophore comprises a three-dimensional representation of a preferred site for modification of at least one of the other molecules with the biological activity, comprising an aggregate average shape of the other molecules with the biological activity, a precursor to the other molecules or a plurality of precursors to the other molecules, and a metabolite of the other molecules or a plurality of metabolites of the other molecules, wherein the aggregate average shape is represented by a coordinate system configured in a computer memory,wherein the designed molecules having altered biological activity possess enhanced biological activity compared to at least one of the other molecules.