Patent ID: 7776834
Filing Date: 2010-08-17
Classification: A61K,A61P

Abstract:
1. An immunostimulatory oligonucleotide having a structure from the group of 5′-TCTGTR′GTTC 5′-CTGTR′GTTCU 5′-CTGTR′GTTC 5′-TCTGTR′GTTCT-X-CGTTCGAACGT-5′ (5′-SEQ ID NO: 7-3′-X-3′-SEQ ID NO: 17-5′); 5′-TCTGTR′GACAG-X-GACAGR′TGTCT-5′ (5′-SEQ ID NO: 8-3′-X-3′-SEQ ID NO: 8-5′); 5′-TCTGTR′GACA 5′-TCAGTR′GTTAG-X-GATTGR′TGACT-5′ (5′-SEQ ID NO: 10-3′-X-3′-SEQ ID NO: 10-5′); 5′-TCAGTR′GACTG-X-GTCAGR′TGACT-5′ (5′-SEQ ID NO: 11-3′-X-3′-SEQ ID NO: 11-5′); 5′-TR′GTR′GAR′GAT-X-TAGR′AGR′TGR′T-5′(5′-SEQ ID NO: 12-3′-X-3′-SEQ ID NO: 12-5′); 5′-TR′GTR′GTAGTA-X-ATGATGR′TGR′T-5′ (5′-SEQ ID NO: 13-3′-X-3′-SEQ ID NO: 13-5′); 5′-TR′GAAR′GTTCT-X-TCTTGR′AAGR′T-5′ (5′-SEQ ID NO: 14-3′-X-3′-SEQ ID NO: 14-5′); and 5′-TR′GTAR′GTACT-X-TCATGR′ATGR′T-5′ (5′-SEQ ID NO: 15-3′-X-3′-SEQ ID NO: 15-5′), wherein R′=1-(2′-deoxy-β-D-ribofuranosyl)-2-oxo-7-deaza-8-methyl-purine; A