Patent ID: 6790941
Filing Date: 2004-09-14
Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
An isolated zinc finger-nucleotide binding polypeptide variant comprising at least two zinc finger modules wherein the amino acid sequence of at least one zinc finger module of said variant has at least one amino acid sequence modification, wherein said variant is a mutagenized form of a zinc finger binding protein and binds a polynucleotide sequence different from a sequence bound by the zinc finger-nucleotide binding polypeptide from which the variant is derived and wherein the amino acid sequence of each zinc finger module that binds a polynucleotide sequence different from a sequence bound by the zinc finger-nucleotide binding polypeptide from which the variant is derived comprises two cysteines and two histidines, whereby both cysteines are amino proximal to both histidines.