Patent ID: 6713626
Filing Date: 2004-03-30
Classification: A61P,C07D

Abstract:
A process for preparing a compound of formula VII whereinR is C1-C3 alkyl, Y represents a moiety selected from the group consisting of C1-C6 alkoxy, C1-C6 alkyl, C3-C7 cycloalkyl and C3-C7 cycloalkoxy, and Ar is 2,3-dihydro-benzodioxin-5-yl, or phenyl optionally substituted with up to three substituents independently selected from halogen, methoxy, halomethyl, dihalomethyl and trihalomethyl, said process comprising the following steps: a) reacting a compound of formula III with a chiral 2-amino-1-(C3-C5)alkanol in a polar aprotic solvent to form a compound of formula IV wherein L represents a leaving group selected from the group consisting of Cl, Br, mesylate, triflate and tosylate, and * indicates a chiral center; b) converting the compound of formula IV to a compound of formula V wherein X is Cl or Br; and, c) treating the compound of formula V with a compound of formula VI in an aprotic solvent wherein M is an alkali metal.