Patent ID: 6659282
Filing Date: 2003-12-09
Classification: A61K,A61P,C07C

Abstract:
A packaged pharmaceutical composition for treating a PMN responsive state in a subject, comprising:a container holding a therapeutically effective amount of at least one lipoxin compound having the formula wherein X is R1, OR1, or SR1; wherein R1 is (i) a hydrogen atom; (ii) an alkyl of 1 to 8 carbons atoms, inclusive, which may be straight chain or branched; (iii) a cycloalkyl of 3 to 10 carbon atoms; (iv) an aralkyl of 7 to 12 carbon atoms; (v) phenyl; (vi) substituted phenyl wherein Zi, Zii, Ziii, Ziv and Zv are each independently selected from â€”NO2, â€”CN, â€”C(&boxH;O)â€”R1, â€”SO3H, a hydrogen atom, halogen, methyl, â€”ORx, wherein Rx is 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched, and hydroxyl; (vii) a detectable label molecule; or (viii) a straight or branched chain alkenyl of 2 to 8 carbon atoms, inclusive; wherein Q1 is (C&boxH;O), SO2 or (CN), provided when Q1 is CN, then X is absent; wherein Q3 and Q4 are each independently O, S or NH; wherein one of R2 and R3 is a hydrogen atom and the other is (a) H; (b) an alkyl of 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched; (c) a cycloalkyl of 3 to 6 carbon atoms, inclusive; (d) an alkenyl of 2 to 8 carbon atoms, inclusive, which may be straight chain or branched; or (e) RaQ2Rb wherein Q2 is â€”Oâ€” or â€”Sâ€”; wherein Ra is alkylene of 0 to 6 carbons atoms, inclusive, which may be straight chain or branched and wherein Rb is alkyl of 0 to 8 carbon atoms, inclusive, which may be straight chain or branched, provided when Rb is 0, then Rb is a hydrogen atom; wherein R4 is (a) H; (b) an alkyl of 1 to 6 carbon atoms, inclusive, which may be a straight chain or branched; wherein R5 is wherein Zi, Zii, Ziii, Ziv and Zv are each independently selected from â€”NO2, â€”CN, â€”C(&boxH;O)â€”R1, â€”SO3H, a hydrogen atom, halogen, methyl, â€”ORx, wherein Rx is 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched, and hydroxyl or a substituted or unsubstituted, branched or unbranched alkyl group; wherein Y1 is â€”OH, methyl, â€”SH, an alkyl of 2 to 4 carbon atoms, inclusive, straight chain or branched, an alkoxy of 1 to 4 carbon atoms, inclusive, or CHaZb where a+b=3, a=0 to 3, b=0 to 3 and Z is cyano, nitro or a halogen; wherein R6 is (a) H; (b) an alkyl from 1 to 4 carbon atoms, inclusive, straight chain or branched; wherein T is O or S, and pharmaceutically acceptable salts thereof; and instructions for using said lipoxin compound for treating an PMN responsive state in the subject.