Patent ID: 8877970
Filing Date: 2014-11-04
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A complex of formula I, its stereoisomer or pharmaceutically acceptable salt: wherein: V is a bond, O, C═O, C(═X)—NH, a group of or a group of wherein X is O or S; U is a bond or a group of (O—CH 2 —CH 2 —O) p —CH 2 —CH 2 wherein p is an integer ranging from 1 to 3; each W is independently a bond, O, or NH; Z is an aromatic, bicyclic aromatic, heteroaromatic, bicyclic heteroaromatic or heterocyclic ring; m is an integer ranging from 0 to 6; n is an integer ranging from 0 to 6; Metal represents a radionuclide selected from the group consisting of Chelate represents a chelating moiety that coordinates with said radionuclide to form said complex, and the Chelate is selected from the group consisting of tetra-azacyclododecanetetra-acetic acid (DOTA), diethylenetriaminepentaacetic acid (DTPA), bis(pyridin-2-ylmethyl)amine (DPA), quinolinemethylamino acetic acid (QAA), bis(isoquinolinemethyl)amine, bis(quinolinemethyl)amine (DQA), pyridine-2-ylmethylamino acetic acid (PAMA), isoquinolin-3-ylmethylamino acetic acid, bis(thiazol-2-ylmethyl)amine (DTK), and thiazol-2-ylmethylamino acetic acid (MTMA), bis(N-carboxymethylimidazoylamine) (DCMI), bis(N-1,1-dimethoxyethylimidazoylamine) (DMEI), bis(N-methylimidazoylamine) (DMI) and bis(N-hydroxyethylimidazoylamine) (DHI).