Patent ID: 6323227
Filing Date: 2001-11-27
Classification: C07C,C07D

Abstract:
A compound of the formula ##STR363##{character pullout} is a single or double bond;R.sub.a is hydrogen, hydroxy or amino;R.sub.1 and R.sub.2 are hydrogen or taken together are .dbd.NR.sub.9 ;R.sub.3 is hydrogen, --CO.sub.2 R.sub.6, --C(O)R.sub.6, --CONR.sub.6 R.sub.6, --CH.sub.2 OR.sub.7 or --CH.sub.2 SR.sub.7 ;R.sub.4 is hydrogen, alkyl, Q-alkyl or thioheterocyclyl, or a group of formula ##STR364##R.sub.5 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, fused arylcycloalkyl, fused heteroarylcycloalkyl, fused arylcycloalkenyl, fused heteroarylcycloalkenyl, fused arylheterocyclyl, fused heteroarylheterocyclyl, fused arylheterocyclenyl, fused heteroarylheterocyclenyl, aryl, fused cycloalkenylaryl, fused cycloalkylaryl, fused heterocyclylaryl, fused heterocyclenylaryl, heteroaryl, fused cycloalkylheteroaryl, fused cycloalkenylheteroaryl, fused heterocyclenylheteroaryl, fused heterocyclylheteroaryl, aralkyl, heteroaralkyl, aralkenyl, heteroaralkenyl, aralkynyl or heteroaralkynyl;R.sub.6 is hydrogen or lower alkyl;R.sub.7 is hydrogen, lower alkyl, Ar(lower alkyl), lower acyl, aroyl or heteroaroyl;R.sub.8 is hydrogen or lower alkyl;R.sub.9 is hydrogen, R.sub.10 O.sub.2 C--, R.sub.10 O--, HO--, cyano, R.sub.10 CO--, HCO--, lower alkyl, nitro, or Y.sup.1a Y.sup.2a N--;R.sub.10 is alkyl, aralkyl, or heteroaralkyl;Y.sup.1a and Y.sup.2a are independently hydrogen or alkyl;A and B are hydrogen or taken together are a bond;Q is R.sub.7 O-- or R.sub.7 S-- or Y.sup.1 Y.sup.2 N--;Y.sup.1 and Y.sup.2 are independently hydrogen, alkyl, aryl, and aralkyl, or one of Y.sup.1 and Y.sup.2 is acyl or aroyl and the other of Y.sup.1 and Y.sup.2 is hydrogen, alkyl, aryl, and aralkyl;Ar is aryl or heteroaryl; andn is 0, or 2; ora pharmaceutically acceptable salt thereof, a solvate thereof, or prodrug thereof.