Patent ID: 6565879
Filing Date: 2003-05-20
Classification: A61K,Y10S

Abstract:
A method for enhancing the flux of a peptidyl drug through a body surface of an individual so as to achieve therapeutically effective blood levels thereof, the method comprising administering a peptidyl drug and a predetermined amount of a hydroxide-releasing agent to the body surface of the individual, wherein the predetermined amount of the hydroxide-releasing agent is effective to provide a pH in the range of approximately 8.5 to 13 at the localized region of the body surface, during drug administration, and wherein the peptidyl drug and hydroxide-releasing agent are present in a formulation and the amount of hydroxide-releasing agent in the formulation applied to the body surface is the total of (a) the amount required to neutralize any acidic species in the formulation plus (b) an mount equal to approximately 0.25 wt. % to 7.0 wt. % of the formulation.