Patent ID: 6649647
Filing Date: 2003-11-18
Classification: C07D

Abstract:
A method for treating cancer comprising administering to a mammal in need of such treatment a compound of the general formula I or a salt thereof, in which X represents a hydrogen atom or a group â€”NR1R2, â€”CHR8R9, or Ar; Y represents a hydrogen or halogen atom, an oxo or hydroxyl group, an optionally substituted cycloalkyl, aryl, C-linked heteroaryl or heterocyclylalkyl group or a group â€”NR3R4, â€”Oâ€”COâ€”R5 or â€”OR6; and Z represents an oxygen atom; whereR1 and R2 independently represent an optionally substituted alkyl, cycloalkyl, aryl or aralkyl group; or R1 and R2 together with the interjacent nitrogen atom represent an optionally substituted heterocyclic group or an amino group derived from an optionally substituted amino acid ester; R3 represents a hydrogen atom or an optionally substituted alkyl, alkenyl or alkynyl group; R4 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl group; or R3 and R4 together with the interjacent nitrogen atom represent an optionally substituted heterocyclic group or an amino group derived from an optionally substituted amino acid ester; R5 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclic or polycyclic group; R6 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclic or polycyclic group; R8 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, aryl or alkoxycarbonyl group; R9 represents a nitro group or an optionally substituted alkyl, alkenyl, alkynyl, aryl, alkanoyl, aroyl, alkoxycarbonyl or aryloxycarbonyl group; or R8 and R9 together with the interjacent carbon atom represent an optionally substituted cycloalkyl or polycyclic group; and Ar represents an optionally substituted aryl or heteroaryl group; optional substituents being selected from the group consisting of halogen atoms, nitro, cyano, hydroxyl, cyclalkyl, alkyl, alkenyl, haloalkyl, cycloalkyloxy, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, formyl, alkoxycarbonyl, oxo, carboxyl, carboxylato, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphonato, carbamoyl, alkylamido, aryl, aralkyl; halo-, alkyl-, haloalkyl- or alkoxy-substituted aryl, heterocyclic and alkyl- or aryl-substituted heterocyclic groupswith the provisos that(i) when X is a group â€”NR1R2, then Y is an oxo group; (ii) when X is a hydrogen atom, then Y is not an oxo, methoxy, ethoxy or 3-carboxypropanoyloxy group; and (iii) when Y is a hydrogen atom or a hydroxyl group, then X is a group â€”CHR8R9.