Patent ID: 8993295
Filing Date: 2015-03-31
Classification: A61K,A61P,B82Y,C07K,C12N,Y02A

Abstract:
1. A composition comprising; (i) a protoxin fusion protein comprising a first non-native cell-targeting moiety, a selectively modifiable activation domain and a toxin domain; and a (ii) protoxin activator fusion protein comprising a second non-native cell-targeting moiety and a modification domain; wherein: said first cell-targeting moiety of said protoxin fusion protein and said second cell-targeting moiety of said protoxin activator fusion protein each recognize and bind a common target cell; said modification domain comprises protease or phosphatase enzymatic activity exogenous to said target cell; said selectively modifiable activation domain comprises a substrate for said modification domain; and modification of said selectively modifiable activation domain by said modification domain results in activation of said toxin domain.