Patent ID: 7741337
Filing Date: 2010-06-22
Classification: A61P,C07D

Abstract:
1. A substituted azonafide derivative selected from the group consisting of: 11-{[(1Z)-(2,5-dihydroxyphenyl)methylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,5-dihydroxyphenyl)methylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-1,3-benzodioxol-5-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1E)-1,3-benzodioxol-5-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; methyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; 4-chloro-N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}butanamide; 2-(4-chlorophenyl)-N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}acetamide; 1-(1,3-benzodioxol-5-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}urea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-pentylurea; 1-(1,3-benzodioxol-5-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-8-yl}urea; 1-(1,3-benzodioxol-5-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-8-yl}urea hydrochloride; N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-8-yl}carbamoyl)benzamide hydrochloride; ethyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; phenyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-oxododecanamide; N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-oxo-5-phenylpentanamide; ethyl 6-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}amino)-4,6-dioxohexanoate; 4-fluorophenyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; octyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; allyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; isobutyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; 4-chlorobutyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; n-butyl {2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}carbamate; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[4-bromophenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[4-(trifluoromethoxy)phenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[2-methoxyethyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[4-isopropylphenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[4-methoxyphenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[ethyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[allyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[2-methoxyphenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-(3-pyridyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-(2-trifluoromethoxy4-bromophenyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-(2-furylmethyl]thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[4-trifluoromethylphenyl]thiourea; 1-(1,3-benzodioxol-4-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}thiourea; 1-(2,1,3-benzothiadiazol-5-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}thiourea; 1-(1,3-benzodioxol-4-ylmethyl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}thiourea; 1-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}-3-[2-(trifluoromethoxy)phenyl]thiourea; 11-{[(1Z)-(2-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-propoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-phenoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3 (2H)-dione; 11-{[(1Z)-3-(3,4-dichlorophenoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-3-(3,5-dichlorophenoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,3-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,4-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,6-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3,4-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3,5-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,3-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,4-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,5-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,6-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3,4-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3,5-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2,3,4-trifluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-(trifluoromethoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-aminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(2-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(3-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(Z)-(3-cyanobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(Z)-(4-cyanobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 1-{[(1Z)-(4-dimethylaminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(4-diethylaminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-methylbenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-methoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-propoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-phenoxybenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-3-(3,4-dichlorophenoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-3-(3,5-dichlorophenoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-bromobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-chlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,3-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,4-dichlorobenzylidene]amino}-2-[2-(dimethylamino)-ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,6-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3,4-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3,5-dichlorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,3-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,4-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,5-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,6-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3,4-difluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3,5-fluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2,3,4-trifluorobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-(trifluoromethyl)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-(trifluoromethoxy)benzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-aminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(2-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-nitrobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(3-cyanobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-cyanobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-dimethylaminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(4-diethylaminobenzylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(cyclohexylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(cyclooctylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(cyclohexylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(cyclooctylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(pyrrol-2-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(thien-2-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(thien-3-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(pyrrolidinylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(pyrid-4-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(pyrid-3-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(pyrrol-2-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(thien-2-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(thien-3-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 8-{[(1Z)-(pyrrolidinylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; 11-{[(1Z)-(pyrid-4-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione; and 11-{[(1Z)-(pyrid-3-ylmethylidene]amino}-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione, and/or a pharmaceutically acceptable salt thereof.