Patent ID: 8187872
Filing Date: 2012-05-29
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A lentiviral vector particle capable of infecting dendritic cells comprising: (a) an envelope comprising an E2 glycoprotein variant having at least 90% identity to amino acids 66 to 488 of SEQ ID NO: 3, wherein (i) residue 160 of the E2 glycoprotein variant (corresponding to amino acid 225 of SEQ ID NO: 3) is absent or is an amino acid other than glutamic acid, (ii) residue 70 of the E2 glycoprotein variant is a non-basic residue, and (iii) the E2 glycoprotein variant is not part of a fusion protein with Sindbis virus E3 glycoprotein; and (b) a lentiviral vector genome comprising a nucleotide sequence encoding an antigen.