Patent ID: 6428956
Filing Date: 2002-08-06
Classification: B01J,C12Q,C40B,H01J,Y10T

Abstract:
A method for screening a plurality of biomolecular targets against a binding agent comprising:(a) providing n different biomolecular targets, wherein n is an integer greater than or equal to 2; (b) modifying nâˆ’1 of said biomolecular targets with mass modifying tags, wherein the mass to charge ratios of ions of about the same charge of said modified biomolecular targets are substantially distinguishable by mass spectrometry; (c) combining said modified biomolecular targets with a binding agent; (d) ionizing said combination from step (c) in a mass spectrometer to provide a plurality of ions, and (e) collecting mass spectral data from the ionization of step (d) and identifying therefrom ion abundances of said modified biomolecular targets and any complexes formed between said binding agent and said modified biomolecular targets.