Patent ID: 7226748
Filing Date: 2007-06-05
Classification: A61K,A61P,G01N

Abstract:
1. A method for detecting multidrug resistance or multidrug resistance potential in a test neoplastic cell, comprising: a) measuring a level of cell surface-expressed HSC70 protein in the test neoplastic cell of a given origin or cell type; and b) comparing the level of cell surface-expressed HSC70 protein in the test neoplastic cell to the level of cell surface-expressed HSC70 in a nonresistant neoplastic cell of the same origin or cell type, wherein the test neoplastic cell is multidrug resistant or has multidrug resistance potential if the level of cell surface-expressed HSC70 in the test neoplastic cell is greater than the level of cell surface-expressed HSC70 in the nonresistant neoplastic cell of the same given origin or cell type.