Patent ID: 6031099
Filing Date: 2000-02-29
Classification: A61P,C07D

Abstract:
A piperidine compound having Formula I: ##STR21## wherein R.sup.1 is --D--B--A--R wherein B is an up to 19 membered spacer group selected from alkylene, alkenylene and alkynylene which is optionally branched or straight chain and optionally substituted with hydroxy, which again is optionally esterified with an aliphatic carboxylic acid having from two to twenty-four carbon atoms, inclusive,A is a bond or a divalent group selected from O, S, SO, SO.sub.2, and ##STR22## W being O or S and the dashed line designating an optional bond; R is alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenyl, cycloalkylalkyl, cycloalkenylalkyl, phenylalkyl, any alkyl group optionally being substituted with one or two hydroxy groups, which again is optionally esterified with an aliphatic carboxylic acid having from two to twenty-four carbon atoms inclusive, and any phenyl group being optionally substituted with one or more substituents on the phenyl ring; andD is CR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are independently selected from the substituents defined below for R.sup.4 -R.sup.7, or a cycloalkylene group;R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl or are optionally linked together to form an ethylene or propylene bridge;R.sup.4 to R.sup.7 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, lower alkylamino and lower dialkylamino; andZ.sup.1 and Z.sup.2 are linked together; wherein Z.sup.1 is CH.sub.2, O or S; Z.sup.2 is CH.sub.2, O or S; and Z.sup.3 is a bond; with the proviso that Z.sup.1 is not S or O when Z.sup.2 is S or O; wherein at least one of Z.sup.1 and Z.sup.2 is O or S; orZ.sup.1 and Z.sup.2 together optionally represent a group --CH.dbd.CH--; or Z.sup.1 and Z.sup.2 together optionally represent a 3-membered divalent group containing one O- or S-heteroatom;with the proviso that D--B--A--R is not phenyl-C.sub.2-4 alkyl, cycloalkyl-C.sub.2-3 -alkyl, C.sub.3-6 lower alkyl or C.sub.4-6 lower alkenyl, wherein phenyl is optionally substituted with one or more substituents; and if Z.sup.1 is O, and Z.sup.2 is CH.sub.2 then --D--B--A--R is not optionally hydroxy-substituted hexyl or heptyl;or an acid addition salt or a prodrug thereof.