Patent ID: 8883720
Filing Date: 2014-11-11
Classification: A61P,C07K

Abstract:
1. A compound of the general formulae wherein are groups of one of the formulae wherein is Gly or Glycolic acid residue, or the residue of an L-α-amino acid with B being a residue of formula —NR20CH(R71)-, or —NR20CH(R72)-, or —NR20CH(R73)- or —NR20CH(R74)- or —NR20OCH(R84)- or the residue of an L-α-hydroxy acid with B being a residue of formula —OCH(R71)- or —OCH(R72)- or —OCH(R73)- or —OCH(R74)- or —OCH(R84)-, or the enantiomer of one of the groups A1 to A69 and A105, or the enantiomer of the groups A106 to A110 as defined hereinafter; is a group of one of the formulae R1 is H; lower alkyl; or aryl-lower alkyl; R2 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sR77; R3 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R4 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR2OCONR33R82; —(CH2)p(CHR61)sCOOR57; —(CH2)p(CHR61)sCONR58R59; —(CH2)p(CHR61)sPO(OR60)2; —(CH2)p(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R5 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R6 is H; alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R7 is alkyl; alkenyl; —(CH2)q(CHR61)sOR55; —(CH2)q(CHR61)sNR33R34; —(CH2)q(CHR61)sOCONR33R75; —(CH2)q(CHR61)sNR20CONR33R82; —(CH2)r(CHR61)sCOOR57; —(CH2)r(CHR61)sCONR58R59; —(CH2)r(CHR61)sPO(OR60)2; —(CH2)r(CHR61)sSO2R62; or —(CH2)r(CHR61)sC6H4R8; R8 is H; Cl; F; CF3; NO2; lower alkyl; lower alkenyl; aryl; aryl-lower alkyl; —(CH2)o(CHR61)sR77-(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)NR33R34-(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sCOR64; R9 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R10 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R11 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R12 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)r(CHR61)sCOOR57; —(CH2)r(CHR61)sCONR58R59; —(CH2)r(CHR61)sPO(OR60)2; —(CH2)r(CHR61)s SO2R62; or —(CH2)r(CHR61)sC6H4R8; R13 is alkyl; alkenyl; —(CH2)q(CHR61)sOR55; —(CH2)q(CHR61)sSR56; —(CH2)q(CHR61)sNR33R34; —(CH2)q(CHR61)sOCONR33R75; —(CH2)q(CHR61)sNR20CONR33R82; —(CH2)q(CHR61)sCOOR57; —(CH2)q(CHR61)sCONR58R59; —(CH2)q(CHR61)sPO(OR60)2; —(CH2)q(CHR61)s SO2R62; or —(CH2)q(CHR61)sC6H4R8; R14 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)q(CHR61)sCOOR57; —(CH2)q(CHR61)sCONR58R59; —(CH2)q(CHR61)sPO(OR60)2; —(CH2)q(CHR61)sSOR62; or —(CH2)q(CHR61)s C6H4R8; R15 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R16 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R17 is alkyl; alkenyl; —(CH2)q(CHR61)sOR55; —(CH2)q(CHR61)sSR56; —(CH2)q(CHR61)sNR33R34; —(CH2)q(CHR61)sOCONR33R75; —(CH2)q(CHR61)sNR20CONR33R82; —(CH2)q(CHR61)sCOOR57; —(CH2)q(CHR61)sCONR58R59; —(CH2)q(CHR61)sPO(OR60)2; —(CH2)q(CHR61)s SO2R62; or —(CH2)q(CHR61)sC6H4R8; R18 is alkyl; alkenyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sSR56; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)p(CHR61)sCOOR57; —(CH2)p(CHR61)sCONR58R59; —(CH2)p(CHR61)sPO(OR60)2; —(CH2)p(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R19 is lower alkyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sSR56; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)p(CHR61)sCOOR57; —(CH2)p(CHR61)sCONR58R59; —(CH2)p(CHR61)sPO(OR60)2; —(CH2)p(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; or R18 and R19 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R20 is H; alkyl; alkenyl; or aryl-lower alkyl; R21 is H; alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R22 is H; alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R23 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R24 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R25 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R26 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; or R25 and R26 taken together can form: —(CH2)2-6-; —(CH2)rO(CH2)r; —(CH2)rS(CH2)r-; or —(CH2)rNR57(CH2)r-; R27 is H; alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R28 is alkyl; alkenyl; —(CH2)o(CHR61)s-OR55; —(CH2)o(CHR61)s SR56; —(CH2)o(CHR61)s NR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)s COOR57; —(CH2)o(CHR61)s CONR58R59; —(CH2)o(CHR61)s PO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)s C6H4R8; R29 is alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R30 is H; alkyl; alkenyl; or aryl-lower alkyl; R31 is H; alkyl; alkenyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C R32 is H; lower alkyl; or aryl-lower alkyl; R33 is H; alkyl, alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR34R63; —(CH2)m(CHR61)sOCONR75R82; —(CH2)m(CHR61)sNR20CONR78R82; —(CH2)o(CHR61)sCOR64; —(CH2)o(CHR61)s—CONR58R59, —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)s SO2R62; or —(CH2)o(CHR61)sC6H4R8; R34 is H; lower alkyl; aryl, or aryl-lower alkyl; or R33 and R34 taken together can form: —(CH2)2-6-; —(CH2)2-0(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R35 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)p(CHR61)sCOOR57; —(CH2)p(CHR61)sCONR58R59; —(CH2)p(CHR61)sPO(OR60)2; —(CH2)p(CHR61)sSO2R62; or —(CH2)p(CHR61)s C6H4R8; R36 is H, alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)p(CHR61)sCOOR57; —(CH2)p(CHR61)sCONR58R59; —(CH2)p(CHR61)sPO(OR60)2; —(CH2)p(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R37 is H; F; Br; Cl; NO2; CF3; lower alkyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R38 is H; F; Br; Cl; NO2; CF3; alkyl; alkenyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)sC6H4R8; R39 is H; alkyl; alkenyl; or aryl-lower alkyl; R40 is H; alkyl; alkenyl; or aryl-lower alkyl; R41 is H; F; Br; Cl; NO2; CF3; alkyl; alkenyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R42 is H; F; Br; Cl; NO2; CF3; alkyl; alkenyl; —(CH2)p(CHR61)sOR55; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R43 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)sPO(OR60)2; —(CH2)o(CHR61)sSO2R62; or —(CH2)o(CHR61)s C6H4R8; R44 is alkyl; alkenyl; —(CH2)r(CHR61)sOR55; —(CH2)r(CHR61)sSR56; —(CH2)r(CHR61)sNR33R34; —(CH2)r(CHR61)sOCONR33R75; —(CH2)r(CHR61)sNR20CONR33R82; —(CH2)r(CHR61)sCOOR57; —(CH2)r(CHR61)sCONR58R59; —(CH2)r(CHR61)sPO(OR60)2; —(CH2)r(CHR61)s SO2R62; or —(CH2)r(CHR61)sC6H4R8; R45 is H; alkyl; alkenyl; —(CH2)o(CHR61)sOR55; —(CH2)o(CHR61)sSR56; —(CH2)o(CHR61)sNR33R34; —(CH2)o(CHR61)sOCONR33R75; —(CH2)o(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)s(CHR61)sCONR58R59; —(CH2)s(CHR61)sPO(OR60)2; —(CH2)s(CHR61)s SO2R62; or —(CH2)s(CHR61)sC6H4R8; R46 is H; alkyl; alkenyl; or —(CH2)o(CHR61)pC6H4R8; R47 is H; alkyl; alkenyl; or —(CH2)o(CHR61)sOR55; R48 is H; lower alkyl; lower alkenyl; or aryl-lower alkyl; R49 is H; alkyl; alkenyl; —(CHR61)sCOOR57; (CHR61)sCONR58R59; —(CHR61)sPO(OR60)2; —(CHR61)sSOR62; or —(CHR61)sC6H4R8; R50 is H; lower alkyl; or aryl-lower alkyl; R51 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)pPO(OR60)2; —(CH2)p(CHR61)s SO2R62; or —(CH2)p(CHR61)sC6H4R8; R52 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)pPO(OR60)2; —(CH2)p(CHR61)s SO2R62; or —(CH2)p(CHR61)sC6H4R8; R53 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sSR56; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR57; —(CH2)o(CHR61)sCONR58R59; —(CH2)o(CHR61)pPO(OR60)2; —(CH2)p(CHR61)s SO2R62; or —(CH2)p(CHR61)sC6H4R8; R54 is H; alkyl; alkenyl; —(CH2)m(CHR61)sOR55; —(CH2)m(CHR61)sNR33R34; —(CH2)m(CHR61)sOCONR33R75; —(CH2)m(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)COOR57; —(CH2)o(CHR61)sCONR58R59; or —(CH2)o(CHR61)s C6H4R8; R55 is H; lower alkyl; lower alkenyl; aryl-lower alkyl; —(CH2)m(CHR61)sOR57; —(CH2)m(CHR61)sNR34R63; —(CH2)m(CHR61)sOCONR75R82; —(CH2)m(CHR61)sNR20CONR78R82; —(CH2)o(CHR61)s—COR64; —(CH2)o(CHR61)COOR57; or —(CH2)o(CHR61)sCONR58R59; R56 is H; lower alkyl; lower alkenyl; aryl-lower alkyl; —(CH2)m(CHR61)sOR57; —(CH2)m(CHR61)sNR34R63; —(CH2)m(CHR61)sOCONR75R82; —(CH2)m(CHR61)sNR20CONR78R82; —(CH2)o(CHR61)s—COR64; or —(CH2)o(CHR61)sCONR58R59; R57 is H; lower alkyl; lower alkenyl; aryl lower alkyl; or heteroaryl lower alkyl; R58 is H; lower alkyl; lower alkenyl; aryl; heteroaryl; aryl-lower alkyl; or heteroaryl-lower alkyl; R59 is H; lower alkyl; lower alkenyl; aryl; heteroaryl; aryl-lower alkyl; or heteroaryl-lower alkyl; or R58 and R59 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R60 is H; lower alkyl; lower alkenyl; aryl; or aryl-lower alkyl; R61 is alkyl; alkenyl; aryl; heteroaryl; aryl-lower alkyl; heteroaryl-lower alkyl; —(CH2)pOR55; —(CH2)pNR33R34; —(CH2)pOCONR75R82; —(CH2)pNR20CONR78R82; —(CH2)oCOOR37; —(CH2)oPO(OR60)2; R62 is lower alkyl; lower alkenyl; aryl, heteroaryl; or aryl-lower alkyl; R63 is H; lower alkyl; lower alkenyl; aryl, heteroaryl; aryl-lower alkyl; heteroaryl-lower alkyl; —COR64; —COOR57; —CONR58R59; —SO2R62; or —PO(OR60)2; or R34 and R63 taken together can form: —(CH2)2-6-; —(CH2)2-0(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R64 is H; lower alkyl; lower alkenyl; aryl; heteroaryl; aryl-lower alkyl; heteroaryl-lower alkyl; —(CH2)p(CHR61)sOR65; —(CH2)p(CHR61)sSR66; —(CH2)p(CHR61)sNR34R63; —(CH2)P(CHR61)sOC ONR75R82; or —(CH2)P(CHR61)sNR20CONR78R82; R65 is H; lower alkyl; lower alkenyl; aryl, aryl-lower alkyl; heteroaryl-lower alkyl; —COR57; —COOR57; or —CONR58R59; R66 is H; lower alkyl; lower alkenyl; aryl; aryl-lower alkyl; heteroaryl-lower alkyl; or —CONR58R59; R67 is H; Cl; Br; F; NO2; —NR34COR57; —CF3; CN; —OCF3; —OCHF2; —OR57; —SR62; lower alkyl; or lower alkenyl; R68 is H; Cl; Br; F; NO2; —NR34COR57; —CF3; CN; —OCF3; —OCHF2; —OR57; —SR62; lower alkyl; or lower alkenyl; R69 is H; Cl; Br; F; NO2; —NR34COR57; —CF3; CN; —OCF3; —OCHF2; —OR57; —SR62; lower alkyl; or lower alkenyl; R70 is H; Cl; Br; F; NO2; —NR34COR57; —CF3; CN; —OCF3; —OCHF2; —OR57; —SR62; lower alkyl; or lower alkenyl; R71 is lower alkyl; lower alkenyl; —(CH2)p(CHR61)sOR75; —(CH2)p(CHR61)sSR75; —(CH2)p(CHR61)sNR33R34; —(CH2)p(CHR61)sOCONR33R75; —(CH2)p(CHR61)sNR20CONR33R82; —(CH2)o(CHR61)sCOOR75; —(CH2)pCONR58R59; —(CH2)pPO(OR62)2; —(CH2)pSO2R62; or —(CH2)o-C6R67R68R69R7OR76; R72 is alkyl; alkenyl; —(CH2)p(CHR61)sOR85; or —(CH2)p(CHR61)sSR85; R73 is —(CH2)OR77; —(CH2)r-O—(CH2)OR77; —(CH2)rS(CH2)OR77; or —(CH2)rNR20(CH2)OR77; R74 is —(CH2)pNR78R79; —(CH2)pNR77R80; —(CH2)pC(═NR80)NR78R79; —(CH2)pC(═NOR50)NR78R79; —(CH2)pC(═NNR78R79)NR78R79; —(CH2)pNR80C(═NR80)NR78R79; —(CH2)pN═C(NR78R80)NR79R80; —(CH2)pC6H4NR78R79; —(CH2)pC6H4NR77R80; —(CH2)pC6H4C(═NR80)NR78R79; —(CH2)pC6H4C(═NOR50)NR78R79; —(CH2)pC6H4C(═NNR78R79)NR78R79; —(CH2)pC6H4NR80C(═NR80)NR78R79; —(CH2)pC6H4N═C(NR78R80)NR79R80; —(CH2)r-O—(CH2)mNR78R79; —(CH2)r-O—(CH2)mNR77R80; —(CH2)r-O—(CH2)pC(═NR80)NR78R79; —(CH2)r-O—(CH2)pC(═NOR50)NR78R79; —(CH2)r-O—(CH2)pC(═NNR78R79)NR78R79; —(CH2)r-O—(CH2)mNR80C(═NR80)NR78R79; —(CH2)r-O—(CH2)mN═C(NR78R80)NR79R80; —(CH2)r-O—(CH2)pC6H4CNR78R79; —(CH2)r-O—(CH2)pC6H4C(═NR80)NR78R79; —(CH2)r-O—(CH2)pC6H4C(═NOR50)NR78R79; —(CH2)r-O—(CH2)pC6H4C(═NNR78R79)NR78R79; —(CH2)r-O—(CH2)pC6H4NR80C(═NR80)NR78R79; —(CH2)rS(CH2)mNR78R79; —(CH2)rS(C112)mNR77R80; —(CH2)rS(CH2)pC(═NR80)NR78R79; —(CH2)rS(CH2)pC(═NOR50)NR78R79; —(CH2)rS(CH2)pC(═NNR78R79)NR78R79; —(CH2)rS(CH2)mNR80C(═NR80)NR78R79; —(CH2)rS(CH2)mN═C(NR78R80)NR79R80; —(CH2)rS(CH2)pC6H4CNR78R79; —(CH2)rS(CH2)pC6H4C(═NR80)NR78R79; —(CH2)rS(CH2)pC6H4C(═NOR50)NR78R79; —(CH2)rS(CH2)pC6H4C(═NNR78R79)NR78R79; —(CH2)rS(CH2)pC6H4NR80C(═NR80)NR78R79; —(CH2)pNR80COR64; —(CH2)pNR80COR77; —(CH2)pNR80CONR78R79; or —(CH2)pC6H4NR80CONR78R79; R75 is lower alkyl; lower alkenyl; or aryl-lower alkyl; or R33 and R75 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; or R75 and R82 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R76 is H; lower alkyl; lower alkenyl; aryl-lower alkyl; —(CH2)oOR72; —(CH2)oSR72; —(CH2)oNR33R34; —(CH2)oOCONR33R75; —(CH2)oNR20CONR33R81; —(CH2)oCOOR75; —(CH2)oCONR58R59; —(CH2)oPO(OR60)2; —(CH2)pSO2R62; or —(CH2)oCOR64; R77 is —C6R67R68R69R7OR76 with the proviso that at least two of R67, R68, R69 and R70 are H; or a heteroaryl group of one of the formulae R78 is H; lower alkyl; aryl; or aryl-lower alkyl; or R78 and R82 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R79 is H; lower alkyl; aryl; or aryl-lower alkyl; or R78 and R79, taken together, can be —(CH2)2-7-; —(CH2)2O(CH2)2-; or —(CH2)2NR57(CH2)2-; R80 is H; or lower alkyl; R81 is H; lower alkyl; or aryl-lower alkyl; R33 and R81 taken together can form: —(CH2)2-6-; —(CH2)2O(CH2)2-; —(CH2)2S(CH2)2-; or —(CH2)2NR57(CH2)2-; R82 is H; —CF3; —OCF3; —OCHF2; lower alkyl; aryl; heteroaryl; or aryl-lower alkyl; R83 is H; lower alkyl; aryl; or —NR78R79; R84 is —(CH2)p(CHR61)sOH; —(CH2)pCOOR80; —(CH2)p(CHR61)sSH; —(CH2)pCONR78R79; —(CH2)pNR80CONR78R79; —(CH2)pC6H4CONR78R79; or —(CH2)pC6H4NR80CONR78R79; R85 is lower alkyl; or lower alkenyl; m is 2-4; o is 0-4; p is 1-4; q is 0-2; r is 1 or 2; s is 0 or 1; Z is a chain of 14 α-amino and/or α-hydroxy acid residues, the positions of said amino and/or hydroxy acid residues in said chain being counted starting from the N-terminal amino acid or O-terminal hydroxy acid, whereby these amino or hydroxy acid residues are, depending on their position in the chains, Gly, a Glycolic acid residue, Pro, -A-CO—, or of one of the types C: —NR20CH(R72)CO—; D: —NR20CH(R73)CO—; E: —NR20CH(R74)CO—; F: —NR20CH(R84)CO—; H: —NR20-CH(CO—)—(CH2)4-7-CH(CO—)—NR20-; —NR20-CH(CO—)—(CH2)pSS(CH2)p—CH(CO—)—NR20-; —NR20-CH(CO—)-(—(CH2)pNR20CO(CH2)p—CH(CO—)—NR20-; or —NR20-CH(CO—)-(—(CH2)pNR20CONR20(CH2)p—CH(CO—)—NR20-; and L: —O—CH(R71)CO—; —O—CH(R72)CO—; —O—CH(R73)CO—; —OCH(R74)CO—; or —OCH(R84)CO—; with the proviso that in said chain Z of 14 α-amino and/or α-hydroxy acid residues the amino or hydroxy acid residues in positions 1 to 14 are: at P5, P7 and P13 also D-isomers being possible; and with the further proviso that the molecule contains at least one but not more than 3 α-hydroxy acid residues; enantiomers thereof; and pharmaceutically acceptable salts thereof.