Patent ID: 6187766
Filing Date: 2001-02-13
Classification: A61K,C07D,C07J

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a ring system compound present in an amount to provide 100-500 mg of compound per unit dose;wherein the ring system compound has a ring system and a sulphamate group of the formula: ##STR100##wherein each of R.sub.1 and R.sub.2 is independently selected from II, alkyl, alkenyl, cycloalkyl and aryl, and at least one of R.sub.1 and R.sub.2 is H;wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); andwherein when the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound it provides a substrate for a steroid sulphatase enzyme (EC 3.1.6.2); andwherein when the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH of 7.4 and 37.degree. C. it provides a K.sub.m value of less than 50 .mu.M.