Patent ID: 6511973
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A compound having the formula or a pharmaceutically acceptable salt thereof or all stereoisomers thereof, whereinn is 3; Y is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, cycloalkyl, heteroaryl, cycloheteroalkyl, cyano, nitro, hydroxy, amino, â€”ORa, â€”SRa, R4, R6, R8, and R9 are the same or different and are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl cycloheteroalkyl, cycloalkyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, substituted alkyl-carbonyl, cycloheteroalkylcarbonyl and heteroarylcarbonyl; R3 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl, cycloalkyl, cycloheteroalkyl, cyano, nitro, hydroxy, â€”ORa, â€”SRa, R5, R5a, and R7 are the same or different and are independently selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroaryl, cycloalkyl, aryl, cycloheteroalkyl, R30 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroaryl, cycloalkyl, aryl, cycloheteroalkyl, â€”C(O)thienyl, â€”C(O)furyl, or â€”C(O)aryl; R10 is selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl, cycloalkyl, alkylcarbonyl, arylcarbonyl, cycloheteroalkyl, cycloalkylcarbonyl, substituted alkyl-carbonyl, cycloheteroalkylcarbonyl, heteroarylcarbonyl, or when R9 is hydrogen and R8 and R10 are on adjacent carbons they join to complete a cycloalkyl or phenyl ring;Ra and Rb are the same or different and are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl, cycloheteroalkyl, cycloalkyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, substituted alkyl-carbonyl, cycloheteroalkylcarbonyl, heteroarylcarbonyl, aminocarbonyl, alkylaminocarbonyl and dialkylaminocarbonyl; Rc is hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, cycloheteroaryl, and wherein R3 and R4 and/or Ra and Rb can be taken together with the nitrogen to which they are attached to form a cycloheteroalkyl ring or a heteroaryl ring; R3 and Y can be taken together to form a heteroaryl ring; R3 or R4 or Y can form a ring with R6 which can be a cycloheteroalkyl or a heteroaryl ring; R5 and R5a can be taken together to the carbon to which they are attached to form a cycloalkyl ring, a heteroaryl ring or a cycloheteroalkyl ring, where one or more of R3 R4 or R6 are H, then double bond isomers are possible; the terms â€œsubstituted alkylâ€ , â€œsubstituted alkenylâ€  and â€œsubstituted alkynylâ€  refer to such alkyl, alkenyl, and alkynyl groups having one, two, or three substituents selected from halo, alkoxy, haloalkoxy, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, arylcycloalkyl, aryloxy, arylalkoxy, heteroaryloxo, hydroxy, â€”N3, nitro, cyano, (R20)(R21)Nâ€”, carboxy, thio, alkylthio, arylthio, arylalkylthio, heteroarylthio, alkyl-C(O)â€”, alkoxycarbonyl, (R20)(R21)Nâ€”C(O)â€”, arylcarbonyloxy, alkyl-C(O)â€”NHâ€”, alkyl-C(O)â€”N(alkyl)â€”, aryl-C(O)â€”NHâ€”, aryl-C(O)â€”N(alkyl)â€”, aryl-C(O)â€”, arylalkoxycarbonyl, alkoxycarbonyl-NHâ€”, alkoxycarbonyl-N(alkyl)â€”, cycloalkyl-C(O)â€”, cycloheteroalkyl-C(O)â€”, heteroaryl-C(O)â€”, cycloalkyl-C(O)â€”NHâ€”, cycloalkyl-C(O)â€”N(alkyl), cycloheteroalkyl-C(O)â€”NHâ€”, cycloheteroalkyl-C(O)â€”N(alkyl)â€”, heteroaryl-C(O)â€”NHâ€”, heteroaryl-C(O)â€”N(alkyl)â€”, arylsulfinyl, alkylsulfinyl, cycloalkylsulfinyl, cycloheteroalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, alkylsulfonyl, cycloalkylsulfonyl, cycloheteroalkylsulfonyl, heteroarylsulfonyl, (R20)(R21)N-sulfinyl, (R20)(R21)N-sulfonyl, alkyl-SO2â€”NHâ€”, alkyl-SO2â€”N(alkyl)â€”, aryl-SO2â€”NHâ€”, N(alkyl)â€”, cycloalkyl-SO2â€”NHâ€”, cycloalkyl-SO2â€”N(alkyl)â€”, cycloheteroalkyl-SO2â€”NHâ€”, cycloheteroalkyl-SO2â€”N(alkyl)â€”, heteroaryl-SO2â€”NHâ€”, heteroaryl-SO2â€”N(alkyl)â€”, (R20)(R21)Nâ€”C(O)â€”NHâ€”, (R20)(R21C(O)â€”N(alkyl)â€”, hydroxy-NHâ€”C(O)â€”, hydroxy-N(alkyl)â€”C(O)â€”, R20, R21, R22, and R23 are independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, cycloheteroalkyl, and heteroaryl.