Patent ID: 7687258
Filing Date: 2010-03-30
Classification: G01N

Abstract:
1. An electronic device for detection of target biological substances, the device comprising: a. a detection surface formed on a gate of a substantially planar insulated gate field effect transistor; b. a molecular monolayer formed on the detection surface, the molecular monolayer further comprising: c. a signal molecule comprising a head and a tail, wherein the head is a competitive element to the target biological substances and wherein the tail carries electric charge and can be linked to different heads; and d. an electronic circuit coupled to the insulated gate field effect transistor to determine a presence of target biological substances by sensing a level of charge induced in the detection surface in response to signal molecules attached to the affinity binding molecules without a reference voltage signal coupled to the gate, wherein substantially no electric current flows from a target biological substance coupled to the detection surface into the insulated gate field effect transistor.