Patent ID: 6071708
Filing Date: 2000-06-06
Classification: A23C,A23L,A61F,A61K,A61L,C07K,G01N,Y10S

Abstract:
A method for evaluating the disease state of a tissue or body fluid, comprising:comparing in a tissue or body fluid sample a detected amount to an expected amount of an antibody capable of binding to a soluble morphogen complex, said complex comprising a dimeric protein having an amino acid sequence selected from the group consisting of:(a) a sequence having at least 70% homology with the C-terminal seven-cysteine skeleton of human OP-1, residues 330-431 of SID NO. 2, and(b) Generic Sequence 7, SID NO. 20;said dimeric protein being in non-covalent association with a morphogen pro region or fragment thereof.