Patent ID: 6071900
Filing Date: 2000-06-06
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR19## wherein W is oxygen;R is selected from the group consisting of hydrogen, amino, halogen, NHR.sup.6, NR.sup.6 R.sup.7, R.sup.4, --OR.sup.4, --SR.sup.4, --SOR.sup.4, --SO.sub.2 R.sup.4, --Z--C.sub.3-10 -cycloalkyl, --Z--C.sub.4-12 -(cycloalkylalkyl), --O--R.sup.5 --Z--R.sup.4 or --S--R.sup.5 --Z--R.sup.4 ;R.sup.4 is selected from the group consisting of C.sub.1-15 -alkyl, C.sub.2-15 -alkenyl, or C.sub.2-15 -alkynyl, each of which is optionally substituted with one or more independently selected from the group consisting of halogen(s), --CF.sub.3, --CN, phenyl and phenoxy wherein phenyl or phenoxy is optionally substituted with one or more selected from the group consisting of halogen, --CN, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, --OCF.sub.3, --CF.sub.3, --CONH.sub.2 and --CSNH.sub.2 ;Z is oxygen or sulphur;R.sup.5 is selected from the group consisting of C.sub.1-15 -alkyl, C.sub.2-15 -alkenyl, and C.sub.2-15 -alkynyl;Z is oxygen or sulphur;G is the azacyclic or azabicyclic ring system: ##STR20## R.sup.1 and R.sup.2 independently are selected from the group consisting of hydrogen, C.sub.1-15 -alkyl, C.sub.2-5 -alkenyl, C.sub.2-5 -alkynyl, C.sub.1-10 -alkoxy, and C.sub.1-5 -alkyl substituted with a substituent independently selected from the group consisting of --OH, --COR.sup.6', CH.sub.2 -OH, halogen, --NH.sub.2, carboxy, and phenyl;R.sup.6' is hydrogen or C.sub.1-6 -alkyl;R.sup.3 is selected from the group consisting of hydrogen, C.sub.1-5 -alkyl, C.sub.2-5 -alkyenyl, and C.sub.2-5 -alkynyl;m and r, independently, are 0, 1 or 2;q is 1 or 2;or a pharmaceutically acceptable salt thereof.