Patent ID: 7811776
Filing Date: 2010-10-12
Classification: A61B,G01N

Abstract:
1. A method of diagnosing the presence or absence of lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder comprising: (a) determining Vascular Endothelial Growth Factor D (VEGF-D) concentration in a biological sample from a human subject that has tuberous sclerosis complex (TSC) or a cystic or chylous lung disorder selected from the group consisting of lymphangiomatosis, Pulmonary Langerhan's cell histiocytosis (PLCH), emphysema, Sjögren's syndrome with cystic lung disease and Birtt-Hogg-Dube syndrome, and (b) diagnosing the presence or absence of LAM from the VEGF-D concentration, wherein elevated VEGF-D concentration in the sample, compared to VEGF-D concentration in subjects with TSC or said cystic or chylous lung disorder that are free of LAM, is diagnostic of LAM.