Patent ID: 8465776
Filing Date: 2013-06-18
Classification: A61K,A61P

Abstract:
1. A granule consisting essentially of a neutral core coated by: (a) oxycodone or a pharmaceutically acceptable salt of oxycodone, and (b) at least a binding agent, said oxycodone coating being further coated by a subcoat consisting of a compound soluble in gastric fluids and optionally an antistatic agent, wherein said subcoat is further coated by a taste-masking coating consisting of a polymer or copolymer with dialkylaminoalkyl(meth)acrylate units, which is insoluble at a pH above 5.5 but is soluble in gastric juice, and optionally an antistatic agent or a pore-forming agent, wherein the subcoat is adapted to avoid direct contact between the oxycodone or the pharmaceutically acceptable salt of oxycodone and the taste-masking coating such that degradation of oxycodone is inhibited.