Patent ID: 6677310
Filing Date: 2004-01-13
Classification: A61K,C07H

Abstract:
A method of treating a viral infection in a patient or vertebrate animal in need thereof comprising administering to said patient or vertebrate animal in an amount sufficient to effect said treatment, at least one of potentially planar, aromatic, ring-expanded heterocyclic bases, nucleosides and nucleotide compounds having the structure wherein:R1, R3 and R5 are each independently selected from the group consisting of: NH, NH2, O, OH, S, and SH; NH-alkyl, N-alkyl, O-alkyl and S-alkyl wherein the alkyl group is C1-C20; NH-aryl, O-aryl and S-aryl wherein the aryl group is a substituted or unsubstituted phenyl or a heterocyclic group; R2, R4, R7, and R8 are independently selected from the group consisting of hydrogen, C1-C20 alkyl, substituted phenyl, unsubstituted phenyl, unsubstituted heterocycle, substituted heterocycle, aralkyl wherein the alkyl containing 1 to 6 carbon atoms and the aryl is substituted or unsubstituted; R6 is selected from the group consisting of hydrogen, C1-C20 alkyl, substituted phenyl, unsubstituted phenyl, unsubstituted heterocycle, substituted heterocycle, and aralkyl wherein the alkyl containing 1 to 6 carbon atoms and the aryl is substituted or unsubstituted; a glycosyl group selected from the group consisting of ribosyl, 2â€²-deoxyribosyl, 2â€²,3â€²-dideoxyribosyl, 2â€²,3â€²-dideoxy-2â€²-fluororibosyl, 2â€²,3â€²-dideoxy-3â€²-fluororibosyl, 2â€²,3â€²-dideoxy-2â€²,3â€²-fluororibosyl, 2â€²,3â€²-dideoxy-3â€²-azidoribosyl and mono-, di-, and triphosphate derivatives thereof; â€”(CH2)m+n+1â€”Râ€²â€”(CH2)mâ€”Oâ€”(CH2)nâ€”Oâ€”Râ€²; â€”(CH2)m+1â€”Oâ€”Râ€²; â€”(CH2)mâ€”Oâ€”(CH2)nâ€”Râ€²; wherein Râ€² is selected from the group consisting of: hydrogen, H2PO3, H3P2O6, H4P3O9, and alkali metal or alkaline earth metal salts thereof; m is zero to 20, n is zero to 20, and a is zero or one; U, X, Y, Z, W, J, K, and L are selected from the group consisting of C and N; and all chiral forms and stereoisomers of said compounds.