Patent ID: 6083495
Filing Date: 2000-07-04
Classification: A61K,A61P

Abstract:
A method of making a pharmaceutical composition comprising cross-linked polyallylamine, said method comprising the steps of:(a) contacting poly(allylamine) with a difunctional crosslinking agent in an aqueous alkaline solution, said cross-linking agent being present in an amount sufficient for forming a poly(allylamine) gel, thereby producing an aqueous alkaline solution comprising polyallylamine and the cross-linking agent;(b) maintaining the aqueous alkaline solution comprising polyallylamine and the cross-linking agent at room temperature for a sufficient period of time for cross-linking of the poly(allylamine), thereby forming cross-linked polyallylamine gel;(c) washing the cross-linked polyallylamine with water; and(d) at least one step selected from the group consisting of:(i) admixing the cross-linked polyallylamine with a pharmaceutically acceptable carrier, excipient or diluent; and(ii) enclosing the cross-linked polyallylamine within a pharmaceutically acceptable carrier.