Patent ID: 6297237
Filing Date: 2001-10-02
Classification: A61P,C07D,Y02P

Abstract:
A process for the preparation of compounds of formula (I): ##STR15##wherein R is C.sub.2 -C.sub.20 linear or branched alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl or benzyl, which can optionally be substituted by C.sub.1 -C.sub.4 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy group, said process comprising:a) oxidation of eserine with hydrogen peroxide in the presence of a base and subsequent hydrolysis to geneseroline, without isolating the intermediate geneserine;b) acylation of geneseroline with an isocyanate of formula R--N.dbd.C.dbd.O, wherein R is as defined above, in the presence of a basic catalyst;c) optional transformation into a pharmaceutically acceptable salt.