Patent ID: 6515133
Filing Date: 2003-02-04
Classification: A61P,C07D

Abstract:
A diarylimidazole of the formula or a pharmaceutically acceptable salt thereofwhere R1 is pyridyl which is unsubstituted or mono, di or trisubstituted with substituents individually selected from the group consisting of: halogen, hydroxy, trihalomethyl, cyano, straight or branched chain lower thioalkoxy having 1-6 carbon atoms, acyloxy groups, amino, straight or branched chain lower alkyl, having 1-6 carbon atoms, straight or branched chain lower alkoxy, having 1-6 carbon atoms (wherein said alkyl1 and alkoxy1 groups are unsubstituted or substituted by an amino or a mono- or di-alkyl amino group or by a mono- or di-alkarylamino group or by an acyl group), amino mono or disubstituted with straight or branched chain lower alkyl2 having 1-6 carbon atoms, wherein said alkyl2 groups are unsubstituted or substituted with a hydroxy or amino group, alkyl amide, aryl amide or alkaryl amide groups, wherein the nitrogen atom of said alkaryl amide group is bound to the aryl group, mono or di substituted carbamyl wherein the CO group of the carbamyl is bound to the aryl ring and each substituent is a lower alkyl or aryl lower alkyl group, mono or di-alkyl carbamates having up to 6 carbon atoms in each alkyl group or mono or diaryl carbamates, or any two adjacent substituents on the aryl ring are a group of the formula â€”Xâ€”(CH2)nâ€”Yâ€”(CH2)mâ€”Zâ€” where X, Y and Z are either a direct bond, oxygen, sulfur, or NR where R is hydrogen or lower alkyl and n and m are independently 1, 2 or 3; one of R2 and R3 is selected from the group consisting of hydrogen, hydroxymethyl, alkoxymethyl having up to 6 carbon atoms in each alkoxy group, straight or branched chain lower alkyl having 1-6 carbon atoms, and cyano; andthe other of R2 and R3 is chosen from the group consisting of phenyl, naphthyl, indanyl, pyrrolyl, furanyl, thienyl, pyrimidinyl, indolyl, benzofuranyl, thianaphthenyl, isoindolyl, isobenzofuranyl,quinolinyl, isoquinolinyl quinazolinyl, indazoyle, quinoxalinyl, cinnolinyl, 1,2,3,4-tetrahydroquinolinyl, 2,3-dihydroindolyl, phenomorpholinyl, benzodioxazinyl, phenothiomorpholinyl and methylenedioxyphenyl each of which is unsubstituted or mono, di or trisubstituted with substituents individually selected from the group consisting of:halogen, hydroxy, trihalomethyl, cyano, straight or branched chain lower thioalkoxy having 1-6 carbon atoms, acyloxy groups, amino, straight or branched chain lower alkyl1 having 1-6 carbon atoms, straight or branched chain lower alkoxy, having 1-6 carbon atoms (wherein said alkyl1 and alkoxy1 groups are unsubstituted or substituted by an amino or a mono- or di-alkyl amino group or by a mono- or di-alkarylamino group or by an acyl group), amino mono or disubstituted with straight or branched chain lower alkyl2 having 1-6 carbon atoms, wherein said alkyl2 groups are unsubstituted or substituted with a hydroxy or amino group, alkyl amide, aryl amide or alkaryl amide groups, wherein the nitrogen atom of said alkaryl amide group is bound to the aryl group, mono or di substituted carbamyl wherein the CO group of the carbamyl is bound to the aryl ring and each substituent is a lower alkyl or aryl lower alkyl group, mono or di-alkyl carbamate having up to 6 carbon atoms in each alkyl group or mono or diaryl carbamate, or any two adjacent substituents on the aryl ring are a group of the formula â€”Xâ€”(CH2)nâ€”Yâ€”(CH2)mâ€”Zâ€” where X, Y and Z are either a direct bond, oxygen, sulfur, or NR where R is hydrogen or lower alkyl and n and m are independently 1, 2 or 3.