Patent ID: 6562606
Filing Date: 2003-05-13
Classification: A61K,Y10S

Abstract:
A topical composition comprising an agent selected from the group consisting of inhibitors of ceramide synthesis, acylceramide synthesis, glucosylceramide synthesis, sphingomyelin synthesis, fatty acid synthesis, and cholesterol synthesis; inhibitors of phospholipid, glycosphingolipid, acylceramide and sphingomyelin degradation; degradation enzymes of free fatty acid, ceramide, sphingomyelin, acylceramide, and glucosylceramides; and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, together with a pharmaceutically acceptable carrier, wherein the agent is present at a concentration of about 0.01% to about 5.0% by weight of said composition.