Patent ID: 8791110
Filing Date: 2014-07-29
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method for treatment of an Arenavirus infection comprising administering in a therapeutically effective amount to a mammal in need thereof, a compound selected from the group consisting of: N1,N4-diphenylpiperazine-1,4-dicarbothioamide; N-(4-chlorophenyl)-4-methyl-piperazine-1-carbothioamide; N-(3,4-dichlorophenyl)-4-phenyl-piperazine-1-carbothioamide; N-(3-chlorophenyl)-4-methyl-piperazine-1-carbothioamide; N-(2,4-dichlorophenyl)-4-methyl-piperazine-1-carbothioamide; 4-methyl-N-(m-tolyl)piperazine-1-carbothioamide; N-(3,4-dichlorophenyl)piperidine-1-carbothioamide; N-(3,4-dichlorophenyl)morpholine-4-carbothioamide; 4-methyl-N-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide; ethyl 4-[(3,4-dichlorophenyl)carbamothioyl]piperazine-1-carboxylate; N-(3,4-dichlorophenyl)-4-(2-pyridyl)piperazine-1-carbothioamide; N-(3-methoxyphenyl)-4-methyl-piperazine-1-carbothioamide; N-(3,5-dimethylphenyl)-4-methyl-piperazine-1-carbothioamide; N-(2,4-dimethylphenyl)-4-methyl-piperazine-1-carbothioamide; 1-tert-butyl-3-(3,4-dichlorophenyl)thiourea; N-(4-chloro-2,5-dimethoxy-phenyl)-4-methyl-piperazine-1-carbothioamide; N-(4-anilinophenyl)-4-methyl-piperazine-1-carbothioamide; 1-(3,4-dichlorophenyl)-3-(4-ethylphenyl)thiourea; 1-(3,4-dichlorophenyl)-3-(m-tolyl)thiourea; N-(3,4-dichlorophenyl)-4-pyrimidin-2-yl-piperazine-1-carbothioamide; N-(3-chloro-4-fluoro-phenyl)-4-methylsulfonyl-piperazine-1-carbothioamide; N-(3-chloro-4-methyl-phenyl)-4-ethyl-piperazine-1-carbothioamide; 1-(3-chloro-4-fluoro-phenyl)-3-[4-(diethylamino)phenyl]thiourea and 1-[(3-chlorophenyl)methyl]-1-(2-morpholinoethyl)-3-phenyl-thiourea.