Patent ID: 7223419
Filing Date: 2007-05-29
Classification: A61K,A61P

Abstract:
1. A process for the production of a polymeric micelle charged therein with a water-scarcely soluble drug, comprising the steps of: (A) dissolving a water-scarcely soluble drug and a block copolymer having a hydrophilic segment and a hydrophobic segment in a water non-miscible organic solvent to prepare an organic solution, wherein the block copolymer is represented by the following Formula (I) or (II) wherein R (B) mixing the resulting organic solution with an aqueous medium to form an oil-in-water (O/W) type emulsion, (C) vaporizing and removing the above organic solvent from the resulting emulsion to form a polymeric micelle solution charged therein with die above drug, and (D) subjecting the resulting polymeric micelle solution, if necessary, to supersonic treatment and ultrafiltraton treatment.