Patent ID: 8513427
Filing Date: 2013-08-20
Classification: C07D

Abstract:
1. A process for producing a substituted sulfoxide compound of formula-I or formula-Ia enantiomer thereof, in which, wherein the process comprising: with alkali salt of methylmercaptane to obtain thio derivative of formula-2 followed by oxidation using an oxidizing agent to obtain a mesyl derivative of formula-3; b) chlorinating the mesyl derivative of formula-3 in a solvent to obtain a compound of formula-5 or its salt; c) condensing the compound of formula-5 with 2-mercaptobenzimidazole of compound of formula-8 in the presence of a base to obtain a benzimidazole sulfide of formula-6. d) oxidizing the compound of formula-6 in a solvent to obtain benzimidazole sulfoxide of formula-7a; e) stereoselectively oxidizing the compound of formula-6 using an optically active compound in the presence of a metal catalyst and a solvent to obtain the compound of formula-7b; and f) reacting the compound of formula-7a or 7b with an alcohol of formula HOR′ to obtain substituted sulfoxide compound of the formula-I or the formula-Ib respectively.