Patent ID: 8722662
Filing Date: 2014-05-13
Classification: A61P,C07D

Abstract:
1. A compound represented by formula (I) wherein ring A is an optionally substituted 6-membered aromatic ring, and the group represented by is wherein ring B 1 -B 6 are optionally further substituted, provided a hydrogen atom bonded to a nitrogen atom constituting rings B 1 -B 6 is not substituted, and R is a cyano group, an optionally substituted carboxy group, an optionally substituted amino group, an optionally substituted C 1-6 alkyl group, an optionally substituted C 1-6 alkoxy group, an optionally substituted C 1-6 alkyl-carbonyl group, an optionally substituted carbamoyl group, an optionally substituted C 6-12 aryloxy group, an optionally substituted aromatic heterocyclyl-oxy group, an optionally substituted aromatic heterocyclic group, or an optionally substituted nonaromatic heterocyclic group, wherein the “optionally substituted carboxy group” is selected from the group consisting of (1) a carboxy group, (2) a C (3) a C (4) a C the “optionally substituted amino group” is selected from the group consisting of (1) an amino group, (2) a mono- or di-C (3) a mono- or di-C (4) a mono- or di-C (5) a mono- or di-C (6) a hydrazino group, (7) a mono- or di-(C (8) a mono- or di-(C (9) a mono- or di-(C (10) a mono- or di-(aromatic heterocyclyl-sulfonyl)amino group, (11) —NR (12) —NR (13) an optionally substituted cyclic amino group; the “optionally substituted carbamoyl group” is —CO—NR wherein R (a) a hydrogen atom, (b) a C (c) a C (d) a C (e) a C (f) a C (g) a C wherein substituents on ring A are optionally bonded to form, together with ring A, an optionally substituted 9- or 10-membered aromatic fused ring, provided that (1) a compound, wherein a partial structure of the formula (I): ring A is a benzene ring, and R is R (2) 2-methyl-2-phenyl-1,4-oxazepane, (3) 6-methyl-6-phenyl-1,4-oxazepane, (4) (2R)-2-phenyl-2-(trifluoromethyl)-1,4-oxazepane, and (5) 7-methyl-7-phenyl-1,4-oxazepane are excluded, or a salt thereof.