Patent ID: 6384053
Filing Date: 2002-05-07
Classification: C07D

Abstract:
A compound of the formula I wherein R1 is H, OH, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2; R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol; R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrollidine, azepine, or pipecoline; R6 is OH, O(C1-C6 alkyl), O(aryl), O(C1-C6 alkyl)aryl)), OCH2CH2cyano, O((C1-C6 alkyl)C1-C6 alcohol), OSO2CH3, OSO2C6H4CH3, SH, S(C1-C6 alkyl), NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, cyano, or halo; and pharmaceutically acceptable salts thereof.