Patent ID: 6498162
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A compound of Formula I wherein:Ar is an unsubstituted or mono- to penta-substituted phenyl, or unsubstituted or mono- or disubstituted naphthyl, wherein the substituents of the phenyl and naphthyl group of Ar independently of one another are selected from F, Cl, Br, I, (C1-4)alkyl, Oâ€”(C1-4)alkyl, CF3, OCF3, or NR12R13 wherein R12 and R13 independently of one another are H, methyl, or acetyl, or Ar is phenyl substituted by â€”Oâ€”CH2â€”Oâ€” or â€”Oâ€”(CH2)2â€”Oâ€”; R1 and R2 together with the N to which they are bound are a ring of the formula R6 is H, (C1-5)alkyl, (C3-5)alkenyl, propynyl, hydroxy(C2-4)alkyl, methoxy(C2-4)alkyl, di(C1-3)alkylamino(C2-4)alkyl, amino(C2-4)alkyl, amino, di(C1-3)alkylamino, monofluoro- to perfluoro(C1-2)alkyl, N-methylpiperidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, or the group â€”CH2â€”C(O)NR14R15, wherein: R14 is H or (C1-4)alkyl, and R15 is H, (C1-4)alkyl, (C3-6)cycloalkyl, hydroxy(C2-4)alkyl, alkoxy(C2-3)alkyl, phenyl(C1-4)alkyl, or R14 and R15 together with the N to which they are bound form a 1-pyrrolidinyl, piperidino, morpholino, or 1-methylpiperazin-4-yl ring; R9 and R10 independently of each other are (C1-4)alkyl; R11 is H, (C1-5)alkyl, (C3-5)alkenyl, propynyl, hydroxy(C2-4)alkyl, methoxy(C2-3)alkyl, di(C1-3)alkylamino(C2-3)alkyl, amino(C2-3)alkyl, amino, di(C1-3)alkylamino, monofluoro- to perfluoro(C1-2)alkyl, N-methylpiperidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or the group â€”CH2â€”C(O)NR23R24, wherein R23 and R24 are defined as R14 and R15 hereinbefore; R3 is H or (C1-4)alkyl; R4 is pheny(C1-4)alkyl or naphthyl(C1-4)alkyl, wherein phenyl is optionally substituted by 1 to 3 substituents, wherein the substituents independently of one another are F, Cl, Br, I, (C1-4)alkyl, Oâ€”(C1-4)alkyl, CF3, OCF3, or NR27R28 wherein R27 and R28 independently of one another are H, methyl, or acetyl; and R5 is H, (C1-4)alkyl, (C3-6)cycloalkyl, CH2COOH, CH2C(O)NH2, OH or phenyl(C1-4)alkyl, or a pharmaceutically acceptable salt thereof.