Patent ID: 6165506
Filing Date: 2000-12-26
Classification: A61K,A61P

Abstract:
A solid dose nanoparticulate naproxen formulation having a high rate of dissolution comprising:(a) naproxen having an effective average particle size of less than about 600 nm;(b) polyvinylpyrrolidone adsorbed on the surface thereof, and(c) a pharmaceutically acceptable alkali agent, wherein following administration the alkali agent functions to increase the dissolution rate of the drug matrix surrounding the nanoparticulate naproxen in the solid dose formulation;wherein the solid dose formulation is made by:(1) preparing a nanoparticulate naproxen composition having polyvinylpyrrolidone adsorbed on the surface thereof;(2) drying the nanoparticulate naproxen composition;(3) adding to the dry nanoparticulate naproxen composition a pharmaceutically acceptable alkali agent; and(4) compressing the mixture of dry nanoparticulate naproxen, polyvinylpyrrolidone, and a pharmaceutically acceptable alkali agent to form a solid dose formulation.