Patent ID: 7358374
Filing Date: 2008-04-15
Classification: A61P,C07D

Abstract:
1. A purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol, having an impurity level less than 0.1%, wherein said purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol is purified by a method comprising: (a) suspending racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol in a mixture of ethanol and tetrahydrofuran to form a suspension; (b) agitating and heating said suspension; (c) cooling said suspension of step (b); and (d) collecting a solid purified racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol.