Patent ID: 6635027
Filing Date: 2003-10-21
Classification: A61B,A61M

Abstract:
An intramural substance delivery system for delivering a therapeutic or diagnostic lining penetration infusate as a plurality of lining penetration jets through a body vessel wall lining and intramurally into the body vessel wall comprising:an infusion catheter having a side wall and catheter lumen extending between a catheter proximal end and a catheter distal end, an elongated infusion segment having a plurality of closely spaced apart, infusion holes in said side wall that extend from said catheter lumen to the outer surface, said spaced apart infusion holes having a diameter of about 0.01 cm and distributed over a length of the infusion segment of about 0.2 cm to about 2.0 cm in a helical pattern and in a density of 20-32 infusion holes per centimeter length of said helical pattern, and a valve in said catheter distal end that is normally closed to close the catheter lumen distal end and penetrable by a guidewire for receiving said guidewire and allowing advancement of said infusion catheter over the guidewire to orient the infusion segment side wall of the infusion catheter with respect to a section of the body vessel wall and for allowing withdrawal of the guidewire proximally from said valve to allow said valve to close and from said catheter lumen to allow said catheter lumen to be filled with the lining penetration infusate; and means for injecting a predetermined bolus of the lining penetration infusate at a predetermined rate into said catheter lumen at a pressure that effects ejection of the lining penetration infusate at high velocity through said infusion holes as fine lining penetration jets of lining penetration infusate to mechanically penetrate the lining of the vessel wall.