Patent ID: 6509356
Filing Date: 2003-01-21
Classification: A61P,C07C,C07D

Abstract:
A compound of the structure: or a pharmaceutically acceptable salt thereof wherein:R1 and R2 are independently selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, and phenacyl; X is â€”(CH2)n where n is an integer of one to 6, inclusive; Y is absent or is selected from the group consisting of 1,4-piperazinylene; ureido; N-(lower alkyl)ureido; Nâ€²-(lower alkyl)ureido; and N,Nâ€²-(di-lower alkyl ureido; Z is selected from the group consisting of: 1-, 2-, or 3-pyrrolidinyl; 2-, or 3-[1-(lower alkyl)pyrrolidinyl]; 1-, 2-, 3-, or 4-piperidinyl; 2-, 3-, or 4-[1-(lower alkyl)piperidinyl]; N-monoalkylamino in which the alkyl group is from one to four carbon atoms; N,N-dialkylamino in which the alkyl groups are independently from one to four carbon atoms; 1-azepinyl; 1- or 2-naphthylamino; 4-morpholinyl; dimethyl-4-morpholinyl; 3-azaspiro[5.5]undecan-3-yl; pyrrolidinonyl-1-yl; unsubstituted phenyl; and phenyl substituted with one or two groups independently selected from acyl of two to four carbon atoms, alkyl of one to four carbon atoms, halo, and alkoxy of one to four carbon atoms; with the proviso that n is 4, 5 or 6 when Z is 1-, 2-, or 3-pyrrolidinyl; 2-, or 3-[1-(lower alkyl)pyrrolidinyl]; 1-, 2-, 3-, or 4-piperidinyl; 2-, 3-, or 4-[1-(lower alkyl)piperidinyl]; N,N-dialkylamino in which the alkyl groups are independently from one to four carbon atoms: 1-azepinyl; 4-morpholinyl, or dimethyl-4-morpholinyl.