Patent ID: 6559129
Filing Date: 2003-05-06
Classification: A61K,C07H,C12N

Abstract:
A method of radiosensitizing raf oncogene expressing tumor tissue in a subject in need of such treatment comprising administering a radiosensitizing effective amount of a cationic liposomal formulation comprising at least one cationic lipid selected from the group consisting of dimethyldioctadecyl ammonium bromide (DDAB); 1,2-dioleoyl-3-trimethyl ammonium propane (DOTAP), N-(2,3-(dioleoyloxy)propyl)-N,N,N-trimethyl ammonium chloride; 1-[2-(9(Z)-octadecenoyloxy)-ethyl]-2-(8(Z)heptadecenyl)-3-(2-hydroxyethyl)-imidazolinium chloride); and 1,2-dimyristoyl-3-trimethyl ammonium propane (DMTAP); and further comprising phosphatidylcholine and cholesterol; and further having encapsulated therein at least one antisense oligonucleotide that is at most 40 bases which specifically binds to a Raf-1 nucleic acid sequence expressed by said tumor tissue.