Patent ID: 6500453
Filing Date: 2002-12-31
Classification: A61K,C07C,C11C

Abstract:
A polymerized liposome which comprises from about 1 to about 50% polymerizable fatty acids of the formula:R4â€”X-PEG-Yâ€”B or a pharmaceutically acceptable salt thereof, wherein R4 is a lipophilic chain containing at least one polymerizable moiety; each of X and Y is independently a chemically stable bond or a linker moiety; and B is â€”Oâ€”C(O)â€”(CH2)pCO2H, C(O)NHR6, C(O)NH2, an aldehyde or an amine; wherein p is an integer from 0 to 12; R6 is a C1 to C5 alkyl group; and PEG is a polyethylene glycol group having an average molecular weight of about 200 to about 2000 grams/mole.