Patent ID: 8333991
Filing Date: 2012-12-18
Classification: A61K,A61P

Abstract:
1. A method for administering a therapeutically effective amount of gabapentin to a human subject, comprising: administering a dosage form comprising gabapentin or a pharmaceutically acceptable salt thereof, wherein the dosage form comprises (a) at least one component that expands on contact with water, a gas-generating agent, and the gabapentin or pharmaceutically acceptable salt thereof; and (b) at least one hydrophilic membrane which encases at least the gas-generating agent; and whereby gabapentin is released from the dosage form into the upper gastrointestinal tract over about 5-12 hours at a rate sufficient to achieve a lower maximum plasma concentration than that provided by an immediate release dosage form comprising an equal amount of gabapentin, and bioavailability of gabapentin is at least 80% of that provided by the immediate release dosage form comprising an equal amount of gabapentin as measured by the area under the plasma concentration-time curve, AUC