Patent ID: 8193322
Filing Date: 2012-06-05
Classification: A61P,C07K

Abstract:
1. A heterodimeric polypeptide comprising (a) a human or humanized IgG1, IgG2, or IgG4 heavy chain from an antibody that binds specifically to an antigen and that comprises an Fe region, wherein the heavy chain comprises a heavy chain variable (V (b) a fusion protein, wherein the fusion protein comprises a light chain from the antibody followed by a human IgG1, IgG2, or IgG4 Fe molecule, wherein the light chain comprises a light chain variable (V wherein the heavy chain and the fusion protein are two polypeptide chains that are oriented identically with respect to their N- and C-termini and associate to form the heterodimeric polypeptide, wherein the heterodimeric polypeptide is monovalent, and wherein the heterodimeric polypeptide is capable of specifically binding to the antigen.