Patent ID: 6617304
Filing Date: 2003-09-09
Classification: C07D

Abstract:
A method for producing a macrocyclic lactone represented by a formula (2), which comprises subjecting a hydroxycarboxylic acid ester represented by a formula (1) to intramolecular esterification: wherein m is an integer of from 5 to 10, n is an integer wherein m+n becomes from 11 to 16, X represents â€”CH2â€”, â€”CH&boxH;CHâ€”, â€”Oâ€”, â€”Sâ€” or â€”NHâ€”, and R represents a hydrocarbon group having from (m+n+2) to 40 carbon atoms or a group represented by â€”(AO)pR1 wherein AO represents an alkyleneoxy group having from 2 to 4 carbon atoms, p is average addition mole number of alkylene oxide and R1 represents a hydrocarbon group having a specified number of carbon atoms so that the total number of carbon atoms of the â€”(AO)pR1 group becomes from (m+n+2) to 40.