Patent ID: 8993612
Filing Date: 2015-03-31
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method of treating non-small cell lung cancer comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a tautomer, N-oxide, pharmaceutically acceptable ester or pharmaceutically acceptable salt thereof, wherein Ring Hy represents R with the proviso that at least one of R 1 or R 2 is C (3-5) cycloalkyl; Ring Ar represents: T, U and W are CH and V is CH or CF; L A is absent or selected from —(CR′R″)—, O, S(═O) R′ and R″ are the same or different and are independently selected from hydrogen, hydroxy, cyano, halogen, —OR each occurrence of X is independently selected from O, S and —NR Cy is a bicyclic ring selected from substituted or unsubstituted cycloalkyl group, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; each occurrence of R each occurrence of R each occurrence of Y is selected from O, S and —NR each occurrence of q independently represents 0, 1 or 2; with the proviso that the compound of formula (I) is not: N-[4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide or N-[4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-pyrazolo[1,5-a]pyrimidine-2-carboxamide.