Patent ID: 6730695
Filing Date: 2004-05-04
Classification: A61K,A61P,C07D

Abstract:
A compound of formula: in which:R1 represents a halogen atom; a (C1-C4alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; a trifluoromethoxy radical; R2 represents a hydrogen atom; a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; or R2 is in position -6- of the indol-2-one ring and R1 and R2 together represent a divalent trimethylene radical; R3 represents a halogen atom; a hydroxyl; a (C1-C2)alkyl; a (C1-C2)alkoxy; a trifluoromethoxy radical; R4 represents a hydrogen atom; a halogen atom; a (C1-C2)alkyl; a (C1-C2)alkoxy; R4 is in position -3- of the phenyl and R3 and R4 together represent a methylenedioxy radical; R5 represents an ethylamino group; a dimethylamino group; an azetidin-1-yl radical; a (C1-C2)alkoxy; R6 represents a hydrogen atom; a (C1-C4)alkyl; a group â€”(CH2)n-COâ€”R9; a group â€”COâ€”(CH2)n-NR10R11; R7 represents a (C1-C4)alkoxy; R8 represents a (C1-C4)alkoxy; R9 represents a hydroxyl; a (C1-C4)alkoxy; a group â€”NR12R13; R10 and R11 each independently represent a (C1-C4)alkyl; or R10 and R11, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, piperazin-1-yl, morpholin-4-yl or thiomorpholin-4-yl; R12 represents a hydrogen or a (C1-C4)alkyl; R13 represents a (C1-C4)alkyl; a â€”C(CH3)2CH2OH group; a â€”C(CH3)(CH2OH)2 group; a â€”C(CH2OH)3 group; or R12 and R13, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, piperazin-1-yl, morpholin-4-yl or thiomorpholin-4-yl; n is 1 or 2; or a solvate, hydrate or acid-addition salt thereof.