Patent ID: 6368630
Filing Date: 2002-04-09
Classification: A61K,C12Y,Y10S

Abstract:
A composition for the modulated release of a biologically active protein, comprising:a) a biocompatible and biodegradable polymeric matrix; b) an effective amount of a biologically active protein, the biologically active protein being dispersed within the polymeric matrix; and c) a metal cation component for modulating the release of the biologically active protein from the polymeric matrix, wherein said metal cation component is selected from the group consisting of magnesium hydroxide, magnesium carbonate, calcium carbonate, zinc carbonate, magnesium acetate, zinc acetate, magnesium chloride, zinc chloride, magnesium sulfate, zinc sulfate, magnesium citrate and zinc citrate, and wherein the metal cation component is separately dispersed within the polymeric matrix.