Patent ID: 8889648
Filing Date: 2014-11-18
Classification: A61P,C12N,C12Y

Abstract:
1. A pharmaceutical composition for treating or preventing a metabolic syndrome, comprising an siRNA that suppresses the expression of SMS2, wherein said siRNA consists of any one or more siRNAs selected from the group consisting of: (a) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 1 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 2; (b) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 3 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 4; (c) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 7 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 8; (d) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 9 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 10; (e) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 11 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 12; (f) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 13 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 14; (g) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 15 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 16; (h) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 21 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 22; (i) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 23 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 24; (j) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 39 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 40; (k) an siRNA wherein one strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 45 and the other strand of the duplex RNA portion is a base sequence set forth by SEQ ID NO: 46; and (l) an siRNA of any one of (a)-(k), wherein one or more nucleotides are added, inserted, deleted or substituted in one or both of the base sequences, said siRNA having an activity of suppressing the expression of SMS2.