Patent ID: 7179899
Filing Date: 2007-02-20
Classification: A61K,C07K,Y10S

Abstract:
1. A nucleic acid sequence which encodes a humanized or composite anti-TAG-72 antibody or anti-TAG-72 antibody fragment which comprises a CDR-grafted light chain having light chain CDRs of a murine anti-TAG-72 antibody grafted onto a human subgroup IV kappa light chain, and a CDR-grafted heavy chain having heavy chain CDRs of a murine anti-TAG-72 antibody, wherein the murine anti-TAG-72 antibody is selected from the group consisting of CC49 (ATCC No. HB 9459), CC83 (ATCC No. HB 9453), CC46 (ATCC No. HB 9458) CC92 (ATCC No. HB 9454), CC30 (ATCC NO. HB 9457) and CC11 (ATCC No. HB 9455).