Patent ID: 7772224
Filing Date: 2010-08-10
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: wherein: A is O; B is (C(R R R R R W is O, NR X is C or S; Y is O, (R R G-J is selected from: N, N—C(R Q, T, U and V are each independently carbon or nitrogen wherein at least one but no more than three of Q, T, U and V are nitrogen, of which one may be optionally an N-oxide, and wherein when any of Q, T, U, or V is carbon it is unsubstituted or substituted where the substituents are independently selected from R R R “heteroaryl,” except where otherwise defined, is a stable 5- to 7-membered monocyclic- or stable 9- to 10-membered fused bicyclic heterocyclic ring system which contains an aromatic ring, any ring of which may be saturated, partially saturated, or unsaturated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring; “heterocycle,” except where otherwise defined, is a stable 5- to 7-membered monocyclic- or stable 8- to 11-membered bicyclic heterocyclic ring system which is either saturated or unsaturated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring; p is 0 to 2q+1, for a substituent with q carbons; m is 0, 1 or 2; n is 1; s is 1, 2 or 3; or a pharmaceutically acceptable salt or individual diastereomers thereof.