Patent ID: 8895737
Filing Date: 2014-11-25
Classification: A61K,A61P,B01J,C07D

Abstract:
1. A process for preparing N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide (compound (A)) or a salt thereof, wherein the process comprises: sulfonamidating compound (5) using a transition metal catalyst precursor and a ligand or a salt thereof: wherein R wherein the ligand is a compound of formula (I) wherein Ar R X is a phosphine of formula (Ia): wherein ring A is a monocyclic heterocyclic ring, bicyclic heterocyclic ring, or tricyclic heterocyclic ring, and wherein ring A includes 0 to 9 ring atoms in addition to the phosphorus and 2 carbon ring atoms of formula (Ia), wherein said ring atoms are each independently selected from the group consisting of carbon, oxygen, nitrogen and sulfur; or X is a phosphine of formula (Ib):  or X is a phosphine fused to Ar wherein, ring B is a phosphorus heterocyclic ring with 0 to 5 ring atoms in addition to the phosphorous and carbon ring atoms of formula (I-c), wherein said ring atoms are each independently selected from the group consisting of carbon, oxygen, nitrogen and sulfur, and wherein the ring atoms of ring A and ring B are each independently optionally substituted with one or more substituents selected from the group consisting of alkenyl; alkoxy; alkoxyalkyl; alkyl; alkylamino; alkylthio; alkynyl; aminoalkyl; N-alkylaminoalkyl; N,N-dialkylaminoalkyl; N,N,N-trialkylammoniumalkyl; arylalkyl optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, cyano, halo, haloalkyl or haloalkoxy; cycloalkyl optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, cyano, halo, haloalkyl or haloalkoxy; dialkylamino; halo; haloalkyl; fluoroalkyl; C R as to R i. R ii. R iii. one or more of R iv. at least one of substituents R as to R R one or more of R wherein, if any of substituents R