Patent ID: 6780625
Filing Date: 2004-08-24
Classification: A61K,C07K,C12N

Abstract:
A method for inhibiting the phosphorlyation activity of GSK-3, the method comprising contacting a cell with a peptide inhibitor of glycogen synthase kinase-3 (GSK-3) in an amount effective to inhibit GSK-3 phosphorylation activity said peptide inhibitor comprises a polypeptide from 7 to 50 amino acids having the amino acid sequence XZXXXS(p)X, wherein S(p)=phosphorylated serine or threonine, wherein X=any amino acid, and wherein Z=any amino acid except serine or threonine, and having the ability to inhibit the enzymatic activity of GSK-3, with the proviso that the polypeptide does not contain two or more SXXXS motifs, wherein S=serine, upstream of the S(p) residue.