Patent ID: 8697718
Filing Date: 2014-04-15
Classification: A61J,A61K,B65D

Abstract:
1. A water- and oxygen-occlusive blister pack enclosing an inert atmosphere storing medicinal tablets, the pack comprising: a breachable-by-tablet foil; and a water- and oxygen-occlusive wall in communication with the breachable-by-tablet foil to enclose the inert atmosphere therebetween, the water- and oxygen-occlusive wall comprising a metal and plastic laminate, the laminate comprising a 30-60 μm thick layer of metallic material laminated to a layer of one or both of aliphatic polyamide and polyvinyl chloride, the laminate further protecting the stored tablets from significant chemical decomposition; wherein the tablets contain buprenorphine or a salt or ester thereof and a mixture of anhydrous citric acid and sodium citrate; wherein the tablets do not contain either an antioxidant or a chelating agent due to the water- and oxygen-occlusive wall that protects the tablets from significant chemical decomposition; wherein the laminate consists of a 10-40 μm thick layer of the aliphatic polyamide distal to at least one tablet, and a 40-80 μm thick layer of the polyvinyl chloride in proximity to the at least one tablet; and wherein the breachable-by-tablet foil consists of about 50 g/m