Patent ID: 8486401
Filing Date: 2013-07-16
Classification: A61K,A61P,C07K

Abstract:
1. A monoclonal antibody or antigen binding fragment thereof that binds TrkA and inhibits the functional activation of TrkA, wherein the monoclonal antibody or antigen binding fragment comprises three light chain complementarity determining regions (CDRs), VLCDR1 (CDR1 of the variable region of the light chain) defined by amino acids 46-55 of SEQ ID No 2, VLCDR2 (CDR2 of the variable region of the light chain) defined by amino acids 71-77 of SEQ ID No 2, and VLCDR3 (CDR3 of the variable region of the light chain) defined by amino acids 110-119 of SEQ ID No 2, and three heavy chain CDRs, VHCDR1 (CDR1 of the variable region of the heavy chain) defined by amino acids 176-185 of SEQ ID No 2, VHCDR2 (CDR2 of the variable region of the heavy chain) defined by amino acids 200-216 of SEQ ID No 2 and VHCDR3 (CDR3 of the variable region of the heavy chain) defined by amino acids 249-262 of SEQ ID No 2, wherein the light chain CDRs are arranged as NH-VLCDR1, VLCDR2, VLCDR3-COOH and the heavy chain CDRs are arranged as NH-VHCDR1, VHCDR2, VHCDR3-COOH.