Patent ID: 8420853
Filing Date: 2013-04-16
Classification: A61P,C07C,C07D

Abstract:
1. A pharmaceutical composition comprising an efficient amount of a cyclic compound selected from the group consisting of: 1-2-bis-octyloxy-cyclohexane, butyric acid 2-butyryloxy-trans-cyclohexyl ester, pentanoic acid 2-pentanoyloxy-trans-cyclohexyl ester, hexanoic acid 2-hexanoyloxy-trans-cyclohexyl ester, heptanoic acid 2-heptanoyloxy-trans-cyclohexyl ester, octanoic acid 2-octanoyloxy-trans-cyclohexyl ester, 2-ethyl-hexanoic acid 2-(2-ethyl-hexanoyloxy)-trans-cyclohexyl ester, nonanoic acid 2-nonanoyloxy-trans-cyclohexyl ester, decanoic acid 2-decanoyloxy-trans-cyclohexyl ester, lauric acid 2-lauroyloxy-trans-cyclohexyl ester octanoic acid 2-octanoyloxy-trans-cyclopentyl ester, 2-ethyl-hexanoic acid 2-(2-ethyl-hexanoyloxy)-trans-cyclopentyl ester, octanoic acid 2-octanoyloxy-phenyl ester, octanoic acid 3-octanoyloxy-naphthalene-2-yl ester, 2-ethyl-hexanoic acid 3-(2-ethyl-hexanoyloxy)-naphthalene-2-yl ester, octanoic acid 3-octanoyloxy-pyridine-2-yl ester, octanoic acid 2,3-bis-octanoyloxy-cyclohexyl ester, myo-inositol hexa-O-butanoate, arabinopyranose 1,2,3,4-tetra-O-(3-methyl-2-butenoate), methyl-α-D-glucose tetra-O-butanoate, 1,2-bis-(3-methyl-butoxy)-cyclohexane, 1,2-bis-pentyloxy-cyclohexane, and 1,2-bis-hexyloxy-cyclohexane, or a pharmaceutically acceptable salt thereof as an active ingredient in an amount effective to treat the skin disease caused by over-reproduced melanin, together with pharmaceutically acceptable carriers or diluents, wherein the pharmaceutical composition is a topical preparation selected from cream, gel, patch, spray, ointment, lotion, liniment, and cataplasma.