Patent ID: 6074650
Filing Date: 2000-06-13
Classification: A61K,A61P,B01J,C07K,C12N,G01N,Y02A

Abstract:
An immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate of at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence of a protein containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen, wherein the membrane anchor compound has one of the formulae below: ##STR7## in which A may be sulfur, oxygen, disulfide (-S-S), methylene (--CH.sub.2 --) or --NH--; n=0 to 5, m=1 or 2; C* is an asymmetric carbon atom with an R-configuration or S-configuration, R, R' and R"" are identical or different and are hydrogen or an alkyl, alkenyl or alkynyl group having 7 to 25 carbon atoms, which can be substituted with hydroxyl, amino, oxo, acyl or cycloalkyl groups, wherein R, R' and R"" are not all hydrogen, E in formula IX can be hydrogen or any desired side chain of a natural or artificial amino acid, B in formula VI is ##STR8## and R.sub.1 and R.sub.2 are identical or different and are hydrogen or an alkyl, alkenyl or alkynyl group having 7 to 25 carbon atoms, which can be substituted with hydroxyl, amino, oxo, acyl cycloalkyl groups, --OR, --O--COR, --COOR, --NHCOR or --CONHR, wherein R, R.sub.1, and R.sub.2 are not all hydrogen, where X is a chain of up to 10 amino acids to which the protein or the partial sequence of the viral, bacterial or parasite protein or of a tumor antigen is bonded, or is the protein or the partial sequence itself, wherein the protein or the partial sequence is not a foot and mouth disease viral protein or partial sequence of a foot and mouth disease viral protein.