Patent ID: 6559177
Filing Date: 2003-05-06
Classification: C07D

Abstract:
A compound of formula I, having the structure whereinX is O or S; Y1, Y4, Z1, Z2, Z3, and Z4 are each, independently, hydrogen, â€”OR, halogen, â€”CF3, â€”CF2CF3, â€”CH2CF3, â€”SR2, â€”CN, â€”CH2CN, â€”CH&boxH;CHCN, â€”NO2, â€”CH2NO2, â€”CH&boxH;CHNO2, or â€”COR3; Y2 and Y3 are each, independently, hydrogen, â€”OR, halogen, â€”CF3, â€”CF2CF3, â€”CH2CF3, â€”SR2, â€”CN, â€”CH2CN, â€”CH&boxH;CHCN, â€”NO2, â€”CH2NO2, â€”CH&boxH;CHNO2, or â€”COR3; or Y2 and Y3 are taken together as â€”CH&boxH;CHâ€”CH&boxH;CHâ€” to form a phenyl ring; R is hydrogen, alkyl of 1-6 carbon atoms, â€”CF3, benzyl, â€”CO2R1, or â€”NR4R5; R1 is â€”CF3, alkyl of 1-6 carbon atoms, or benzyl; R2 is hydrogen or alkyl of 1-6 carbon atoms; R3 is alkyl of 1-6 carbon atoms, phenyl, thienyl, furyl, or â€”CF3; R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or are taken together to form a 5-7 memebered heterocyclic ring containing a nitrogen and 4-6 carbon atoms; or a pharmaceutically acceptable salt thereof, with the provisos that(a) Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are all not hydrogen; (b) when Y1, Y2, Y3, and Y4 are hydrogen, Z1, Z2, Z3, or Z4 are not â€”OR; (c) when Z1, Z2, Z3, and Z4 are hydrogen, Y1, Y2, Y3, or Y4 are are not â€”OR; and (d) when Y3 is alkyl of 1-6 carbon atoms, Z3 is not halogen.