Patent ID: 8362229
Filing Date: 2013-01-29
Classification: C12N

Abstract:
1. A compound consisting of four ribonucleotide strands forming three double-stranded siRNA duplexes and having the structure: wherein each of oligo A, oligo B, oligo C, oligo D, oligo E and oligo F represents from 19 to 40 consecutive ribonucleotides, each of which ribonucleotides may be modified or unmodified; wherein strand 1 comprises oligo A which is either a sense portion or an antisense portion of a first siRNA duplex within the compound, strand 2 comprises oligo B which is complementary to at least 19 nucleotides in oligo A, and oligo A and oligo B together form such first siRNA duplex that targets a first target mRNA; wherein strand 1 further comprises oligo C which is either a sense portion or an antisense portion of a second siRNA duplex within the compound, strand 3 comprises oligo D which is complementary to at least 19 nucleotides in oligo C and oligo C and oligo D together form such second siRNA duplex that targets a second target mRNA; wherein strand 4 comprises oligo E which is either a sense portion or an antisense portion of a third siRNA duplex within the compound, strand 2 further comprises oligo F which is complementary to at least 19 nucleotides in oligo E and oligo E and oligo F together form such third siRNA duplex that targets a third target mRNA; and wherein linker A is a moiety that covalently links oligo A and oligo C; linker B is a moiety that covalently links oligo B and oligo F, and linker A and linker B can be the same or different.