Patent ID: 6558435
Filing Date: 2003-05-06
Classification: A61K,B01D,B01F,B01J,C07B,C07C,C07D

Abstract:
A process for synthesis and crystallization of a pharmaceutical compound comprising:contacting one or more liquid jet streams of a solution in a first solvent of a first reactive intermediate and one or more liquid jet streams of a solution in a second solvent of a second reactive intermediate, with each jet stream of said first reactive intermediate substantially diametrically opposite a jet stream of said second reactive intermediate and each jet stream of said second reactive intermediate substantially diametrically opposite a jet stream of said first reactive intermediate when viewed from overhead, so that each jet stream of said first reactive intermediate is directed into a jet stream of said second reactive intermediate and each jet stream of said second reactive intermediate is directed into a jet stream of said first reactive intermediate, such that the liquid streams meet at a point of impingement to create a vertical impingement film and with said jet streams creating turbulence at their point of impact under conditions of temperature and pressure which permit reaction of said first and second reactive intermediates to produce a product; and selecting said first and second solvents so that said product is insoluble in a mixture of said first and second solvents; and with each jet stream having sufficient linear velocity to achieve micromixing of said solutions followed by reaction of first and second reactive intermediates, followed by nucleation of said product and production of high surface area crystals of said product that meet bioavailability requirements.