Patent ID: 6458806
Filing Date: 2002-10-01
Classification: A61K,C07C,C07D

Abstract:
A method of inhibiting the binding of the monocytes chemoattractant protein-1(MCP-1) receptor in a mammal in need thereof comprising administrating to such mammal an effective inhibiting amount of a compound of Formula (I): wherein R is any one of the following moieties: Ar can be unsubstituted or substituted phenyl, biphenyl, or naphthyl;the substituents are defined as: halogen, nitro, CF3, alkyl of from 1-12 carbon atoms; â€”(CH2)rOR6 â€”(CH2)rNR3R4 â€”(CH2)rCONR3R4 â€”(CH2)rC(O)OR6 or â€”(CH2)râ€”SO2â€”OR6; R3, R4, and R6, are independently selected from the group hydrogen and lower alkyl;r=0-4; R7, R8, R9 and R10 each independently are hydrogen, or lower alkyl, or pharmaceutically acceptable salts thereof.