Patent ID: 8722086
Filing Date: 2014-05-13
Classification: A61K

Abstract:
1. A multiparticulate dosage form with impeded abuse, comprising at least one active substance with abuse potential (A) having a psychotropic action and being selected from the group consisting of opioids, at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E), which is selected from the group consisting of crosspovidone and crosscarmellose, wherein at least part of the disintegrant (E) is mixed with the particles of the dosage form, an auxiliary (B2), which is microcrystalline cellulose, and which is not a component of the particles, optionally one or more additional, physiologically acceptable auxiliaries, wherein the individual particles of the dosage form have a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in a paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 revolutions per minute.