Patent ID: 6136793
Filing Date: 2000-10-24
Classification: A61K

Abstract:
A method of treating a disease or condition in humans, said disease or condition selected from the group consisting of i) involving underperfused or pathological tissue; and ii) of the skin or exposed tissue, the method comprising topically administering a pharmaceutical composition from which effective non-toxic dosage amounts may be taken and applied to skin or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical application, an effective non-toxic dosage amount of a drug to treat the disease or condition of a human and an effective non-toxic dosage amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and its non-toxic salts and combination thereof sufficient to transport the drug, to a site in the skin, epidermis or exposed tissue of the disease or condition for percutaneous transport into the skin or exposed tissue to accumulate and remain there for a prolonged period of time and which is systemic independent acting and wherein the concentration of the drug is 3% by weight and the concentration of the form of hyaluronic acid is 2.5% by weight having a molecular weight less than 750,000 daltons and greater than 150,000 daltons and wherein the dosage amount of the form of hyaluronic acid exceeds 5 mg/cm.sup.2 of the skin or exposed tissue to which the dosage amount is to be applied.