Patent ID: 6391285
Filing Date: 2002-05-21
Classification: A61K,A61P,A61Q,C07K

Abstract:
A composition of matter comprising purified lantibiotic mutacin 1140 substantially free of any other Streptococcus mutans host proteins wherein the lantibiotic is isolated from a S. mutans strain and wherein the lantibiotic comprises:(a) antibiotic activity; (b) about 22 amino acid or modified amino acid residues; (c) at least 2 lanthionine residues; (d) at least 3 thioether bridges; (e) at least one 2,3-didehydroalanine amino acid residue; (f) at least one 2,3 didehydrobutyrine amino acid residue; and (g) an S-[aminovinyl]-cysteine.