Patent ID: 7998926
Filing Date: 2011-08-16
Classification: A61K,A61P,C07K

Abstract:
1. A dimer comprising a monomer that (a) consists of, from the N-terminus to the C-terminus direction, the sequence Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr (SEQ ID NO:1) with the proviso that, if the sequences are present as an aqueous solution, then at least 81% of the occurrences of the sequence are present as a dimer; or (b) is a homolog of the β3 peptide of the T-cell receptor β chain clone YT35, the said β3 peptide consisting of, from the N-terminus to the C-terminus direction, the sequence Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr (SEQ ID NO:1), wherein the homolog has the sequence of a segment of another distinct human Vβ gene which segment corresponds to the same segment as the said β3 peptide and wherein the homolog has the sequence Cys-[X]-Trp-[Y], wherein [X] is a 10 or 11 amino acid sequence and wherein [Y] is a 4 amino acid sequence; or (c) is a variant of the monomer of (a) or (b), wherein: