Patent ID: 7601745
Filing Date: 2009-10-13
Classification: A61P,C07D

Abstract:
1. A compound of the general formula (Ih) or pharmaceutically acceptable salts thereof with an acid or base or a stereoisomer thereof, wherein A is NR t is 0 to 4; r is 0, or 1; R R R R R R R R R R R R X is NR Z is N or CR R p is 1 to 6; q is 1 to 6; R R wherein a C R′ is independently H, —CO R″ is independently H, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, or heteroaryl; a C an alkyl group, if not stated otherwise denotes a linear or branched C a cycloalkyl group denotes a non-aromatic ring system containing three to eight carbon atoms, wherein one or more of the carbon atoms in the ring are optionally substituted by one or more substituents R′, R′ being as defined as above; a heterocycloalkyl group denotes a non-aromatic ring system containing two to ten carbon atoms and at least one heteroatom selected from O, N, and S, wherein one or more of the carbon atoms in the ring can be substituted by R′ being as defined above; an alkoxy group denotes an O-alkyl group, the alkyl group being as defined above; an alkylthio group denotes an S-alkyl group, the alkyl group being as defined above; a haloalkyl group denotes an alkyl group which is substituted by one to five halogen atoms, the alkyl group being as defined above; a hydroxyalkyl group denotes an HO-alkyl group, the alkyl group being as defined above; a haloalkyloxy group denotes an alkoxy group which is substituted by one to five halogen atoms, the alkyl group being as defined above; a hydroxyalkylamino group denotes an (HO-alkyl) an alkylamino group denotes HN-alkyl or N-dialkyl group, the alkyl group being as defined above; a halogen group is fluorine, chlorine, bromine, or iodine; an aryl group denotes an aromatic group having five to fifteen carbon atoms, optionally substituted by one or more substituents R′, where R′ is as defined above; an arylamino group denotes an HN-aryl or N-diaryl group, the aryl group being as defined above; a heteroaryl group denotes a 5- to 10-membered aromatic heterocyclic group which contains at least one heteroatom selected from O, N, and S, wherein the heterocyclic group may be fused to another ring and the heterocyclic group or the fused ring can both be substituted independently by one or more substituents R′, wherein R′ is as defined above.