Patent ID: 6811982
Filing Date: 2004-11-02
Classification: C07H,C12Q

Abstract:
A diagnostic method for colon or bladder cancer, comprising:(a) obtaining an isolated test genomic DNA sample from a test tissue; (b) subjecting the test genomic DNA sample to methylation analysis, whereby the methylation state of one or more CpG dinucleotide sequences within a sequence selected from the group consisting of SEQ ID NOS:1-9 and 11, and fragments thereof comprisin at least 16 contiguous bases is determined; and (c) comparing the methylation state of the one or more CpG dinucleotide sequences of the test sample with that of corresponding sequences of a reference genomic sample from a reference genomic tissue, or with that of a corresponding known reference methylation state, thereby providing, at least in part, a colon or bladder cancer diagnosis.