Patent ID: 9139862
Filing Date: 2015-09-22
Classification: C07K,C12Q,G01N

Abstract:
1. A cyclic peptide for quantifying the enzymatic activity of an MMP protease enzyme selected from the group consisting of MMP-1, MMP-2, MMP-3, MMP-5, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-19, MMP-23, MMP-25 and MMP-26, wherein said cyclic peptide comprises: , wherein: S S E X R Y is a —CONH— or —NHCO— group; wherein the MMP protease enzyme is selected from the group consisting of MMP-1, MMP-2, MMP-3, MMP-5, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-19, MMP-23, MMP-25 and MMP-26; and wherein the MMP protease enzyme is MMP-1, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-2, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-3, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-5, and wherein said first sequence S wherein the MMP protease enzyme is MMP-7, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-8, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-9, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-10, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-11, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-12, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-13, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-14, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-15, and wherein said first sequence S wherein the MMP protease enzyme is MMP-16, and wherein said first sequence S wherein the MMP protease enzyme is MMP-17, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-19, and wherein said first sequence S wherein the MMP protease enzyme is MMP-23, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-25, and wherein at least one of said first sequence S wherein the MMP protease enzyme is MMP-26, and wherein at least one of said first sequence S