Patent ID: 8883163
Filing Date: 2014-11-11
Classification: A61K,A61P,C07H,C12N,Y02A

Abstract:
1. A method of immunising a human host against disease caused by Haemophilus influenza (Hib) comprising administering to the human host an immunoprotective dose of an immunogenic composition, wherein the immunogenic composition comprises: a Hib saccharide conjugate; a Neisseria meningitidis ( N. meningitidis ) capsular saccharide conjugate derived from a strain selected from the group consisting of serogroup A, serogroup B, serogroup C, serogroup W135 and serogroup Y; and an antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 μg and the saccharide dose of the N. meningitidis capsular saccharide conjugate is less than 8 μg, and wherein the Geometric Mean Concentration (GMC) for the antigen achieved with said immunogenic composition is higher than the GMC achieved after immunisation with said immunogenic composition containing a 5 μg saccharide dose of Hib saccharide conjugate and an 8 μg dose of N. meningitidis capsular saccharide conjugate.