Patent ID: 6428788
Filing Date: 2002-08-06
Classification: A61K,A61P,C07K

Abstract:
A method for specifically delivering an effector molecule to a cell bearing an IL-13 receptor that does not specifically bind IL-4, said method comprising the steps of:providing a mixture of cells compromising at least a first cell bearing an IL-13 receptor that does not specifically bind IL-4 and at least a second cell bearing an IL-4 receptor but not the IL-13 recptor that does not specifically bind IL-4; providing a chimeric molecule comprising an effector molecule attached to a targeting molecule that specifically binds to the IL-13 receptor; and contacting said mixture of cells with said chimeric molecule in the presence of a blocker of the IL-4 receptor; wherein said blocker is present in a concentration sufficient to block binding of said targeting molecule to said IL-4 receptor; and wherein said chimeric molecule specifically binds to said first cell.