Patent ID: 7674908
Filing Date: 2010-03-09
Classification: A61P,C07D,G01N

Abstract:
1. A process for preparing (1S,3R,5R)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1′): the process comprising reacting 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (9): with at least 25 equivalents of ammonium formate in the presence of a transition metal catalyst to provide (1S,3R,5R)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester.