Patent ID: 8460706
Filing Date: 2013-06-11
Classification: A61K,A61P

Abstract:
1. A controlled-release tablet comprising an amount of an active substance, inclusive of pharmaceutically acceptable salts, which tablet exhibits a release rate over approximately 24 hours in vitro as measured using equipment 2, paddle (USP XXIII), working at 100 rpm and utilizing 900 ml of an aqueous dissolution fluid at 37° C., wherein the release rate of the active substance as a percentage is independent of the amount of active substance in said tablet, the tablet comprising an active layer containing: (i) an active substance, (ii) hydrophilic polymeric substances which swell and/or gel and/or erode upon contact with aqueous liquids, (iii) lipophilic substances, and (iv) adjuvant substances, wherein the weight ratio of the hydrophilic polymeric substances to the lipophilic substances contained in said active layer is in the range of 10:1 to 0.5:1; and wherein the active substance is not ropinirole or a pharmaceutically acceptable salt thereof.