Patent ID: 6670367
Filing Date: 2003-12-30
Classification: A61P,C07C,C07D

Abstract:
A carboxylic acid compound of the formula I where R1 is a group where R isa radical OR7 where R7 is hydrogen, the cation of an alkali metal, the cation of an alkaline earth metal or a physiologically tolerated organic ammonium ion; R2 is hydrogen, hydroxyl, NH2, NH(C1-C4-alkyl, N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy or C1-C4-alkylthio; X is nitrogen; Y is nitrogen; Z is CR10, where R10 is hydrogen or C1-C4-alkyl; R3 is hydrogen, hydroxyl, NH2, NH(C1-C4-alkyl), N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-hydroxyalkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy or C1-C4-alkylthio, or CR3 is linked to CR10 as indicated above to give a 5- or 6-membered ring; R4 and R5, which may be identical or different, are phenyl or naphthyl, unsubstituted or substituted; R6 is substituted phenyl; W is oxygen; Q is a spacer whose length corresponds to that of a C2-C4 chain, or the physiologically tolerated salts, and the enantiomerically pure and diastereoisomerically pure forms thereof wherein the compound has an ETA:ETB affinity ratio of greater than 0.1 and less than 20.