Patent ID: 8703204
Filing Date: 2014-04-22
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising nanoparticle cores having an average size of less than 500 nm, said cores comprising: (a) a cholesteryl ester transfer protein inhibitor (CETPI) having a solubility in water of less than 1 mg/mL over the pH range of 6.5 to 7.5 at 25° C., at least 90 wt % of said CETPI in said nanoparticle being non-crystalline; and (b) a poorly aqueous soluble non-ionizable polymer selected from the group consisting of methylcellulose, ethylcellulose, propylcellulose, butylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, cellulose acetate butyrate, cellulose acetate propionate, methyl cellulose acetate, methyl cellulose propionate, methyl cellulose butyrate, ethyl cellulose acetate, ethyl cellulose propionate, ethyl cellulose butyrate, poly(lactide), poly(glycolide), poly(ε-caprolactone), poly(lactide-co-glycolide), poly(lactide-co-ε-caprolactone), poly(ethylene oxide-co-ε-caprolactone), poly(ethylene oxide-co-lactide), poly(ethylene oxide-co-lactide-co-glycolide), poly(isobutyl)cyanoacrylate, and poly(hexyl)cyanoacrylate; wherein said CETPI and said non-ionizable polymer collectively constitute at least 80 wt % of said cores.