Patent ID: 6734182
Filing Date: 2004-05-11
Classification: C07C,C07D

Abstract:
A compound having the structure: wherein Ar is wherein each Z is independently N or C; wherein p is an integer from 0 to 2; wherein o is an integer from 0 to 1 and a is an integer from 0 to 3; wherein V is S, O, N or NR5; wherein X is a single bond; wherein each R2 is independently H; F; Cl; Br; I; CN; CF3; NO2; OH; C1-C4 alkyl; C2-C4 alkenyl; C1-C4 alkoxy; C1-C4 hydroxyalkyl; C1-C4 methoxyalkyl; C1-C4 monohaloalkyl; C1-C4 polyhaloalkyl; N(R5)2; NHCOR5; N (COR5)2; NHCO2R5; NHCONHR5; NHSO2R5; N(SO2R5) 2; CO2R5; CON(R5)2; SO2N(R5)2; phenoxy; phenyl; pyridyl; thiophenyl; naphthyl; phthalimide; C5-C7 lactam, C5-C7 cyclic imide, C5-C7 cyclic amino; wherein the phthalimide, lactam, cyclic imide, or cyclic amine is linked by nitrogen; and wherein the phenoxy, phenyl, pyridyl, thiophenyl, naphthyl, phthalimide, lactam, cyclic imide, or cyclic amine is substituted with H, F, Cl, Br, I, CF3, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, or NO2; wherein each R3 is independently H; F; Cl; Br; I; CN; CF3; NO2; OH; C1-C4 alkyl; C2-C4 alkenyl; C1-C4 alkoxy; C1-C4 hydroxyalkyl; C1-C4 methoxyalkyl; C1-C4 monohaloalkyl; C1-C4 polyhaloalkyl; N(R5)2; NHCOR5; N(COR5)2; NHCO2R5; NHCONHR5; NHSO2R5; N(SO2R5)2; CO2R5; CON(R5)2; SO2N(R5)2; or R2 and R3 present on adjacent carbon atoms can constitute C5-C7 cycloalkyl, C5-C7 heterocycloalkyl or C5-C7 heteroaryl; wherein each R4 is independently H; F; Cl; Br; I; CN; CF3; NO2; OH; C1-C4 alkyl; C1-C4 alkoxy; C1-C4 hydroxyalkyl; C1-C4 methoxyalkyl; C1-C4 monohaloalkyl; C1-C4 polyhaloalkyl; N(R5)2; NHCOR5; N(COR5)2; NHCO2R5; NHCONHR5; NHSO2R5; N(SO2R5)2; CO2R5; CON(R5)2; or SO2N(R5)2; wherein each R5 is independently H; C1-C3 alkyl; C1-C3 monohaloalkyl; or C1-C3 polyhaloalkyl; wherein Lâ€² is â€”NR1â€”Lâ€”; wherein L is wherein R1 is H; or C1-C3 straight chained alkyl; wherein one dashed line is a double bond and the other dashed line is a single bond; wherein each R6 is independently H; CN; OR5; C1-C5 alkyl; CH2OR5; CON(R5)2; CO2R5; phenyl; pyridyl; thiophenyl or naphthyl; wherein the phenyl, pyridyl, thiophenyl or naphthyl is substituted with H, F, Cl, Br, I, CF3, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, or NO2; wherein i is an integer from 1 to 4; wherein n is an integer from 0 to 3; wherein m is an integer from 0 to 3; wherein K is â€”CH2â€”NR10â€”COâ€”(CH2)jâ€”; â€”CH2â€”NR10â€”COâ€”CHR7â€”(CH2)j; â€”CH2â€”NR10â€”CSâ€”(CH2)jâ€” or â€”CH2â€”NR10â€”CSâ€”CHR7â€” (CH2)j; wherein j is an integer from 0 to 3; wherein R7 is H; C1-C6 alkyl; CH2OR5; (CH2)pNHCO2R5; (CH2)pNHSO2R5; CH2N(R11)2; phenyl; pyridyl; thiophenyl; or naphthyl; wherein W is wherein Q is O; S; N; NR9; or C(R5)2; wherein R8 is independently H; F; Cl; Br; I; NO2; OH; &boxH;O; C1-C4 alkyl; C1-C4 alkoxy; C1-C4 hydroxyalkyl; C1-C4 methoxyalkyl; C1-C4 monohaloalkyl; C1-C4 polyhaloalkyl; N(R5)2; NHCOR5; N(COR5)2; NHCO2R5; NHCONHR5; NHSO2R5; N(SO2R5)2; CO2R5; CON(R5)2; or SO2N(R5)2; wherein R9 is H; C1-C3 alkyl; COR5; CO2R5; CON(R5)2; wherein R10 is H; or C1-C6 alkyl; wherein R11 is H; COR5; COR12; SO2R5; SO2R12; and wherein R12 is phenoxy; phenyl, pyridyl; thiophenyl; or naphthyl; wherein the phenoxy, phenyl, pyridyl, thiophenyl or naphthyl is substituted with H, F, Cl, Br, I, CF3, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, NO2, phenyl, pyridyl or thiophenyl; or a pharmaceutically acceptable salt thereof.