Patent ID: 6825180
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A therapeutic compound, including resolved enantiomers, diastereomers, tautomers, and salts thereof, having the following formula: wherein:R1 is selected from a member of the group consisting of hydrogen, hydroxyl, methoxyl, acylamino group, cyano group, sulfo; sulfinyl, sulfhydryl (mercapto), sulfeno, sulfanilyl, sulfamyl, sulfamino, and phosphino, phosphinyl, phospho, phosphono and â€”NRaRb, wherein each of Ra and Rb may be the same or different and each is selected from the group consisting of hydrogen and optionally substituted: C(1-20)alkyl, C(3-12)cycloalkyl, C(2-20)alkenyl, C(3-12)cycloalkenyl, C(2-20)alkynyl, aryl, heteroaryl, and heterocyclic group; R2 and R3 are independently selected from a member of the group consisting of halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)alkylthio, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(2-20)tetraaminoalkyl, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(2-20)alkenyl, C(2-20)alkynyl, C(1-20)alkoxyl, C(1-20)alkoxyalkyl, C(1-20)dialkoxyalkyl, and âˆ’NRaRb; and R4 may be hydrogen or an optionally substituted member of the group consisting of C(1-20)alkyl, C(3-12)cycloalkyl, C(2-20)alkenyl, C(3-12)cycloalkenyl, C(2-20)alkynyl, aryl, heteroaryl, and heterocyclic group.