Patent ID: 7579356
Filing Date: 2009-08-25
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein L R R p is 0, 1, 2, 3 or 4, L Ar (1)C (2)C (3)C (4)C wherein each (1), (2), (3) and (4) is optionally substituted with one, two or three substituents independently selected from the group consisting of (i) C (ii) aryl, (iii) heteroaryl, (iv)heterocyclyl, wherein each (i), (ii), (iii) and (iv) is optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of (v) amino optionally mono or disubstituted with a substituent independently selected from the group consisting of (vi) hydroxy, (vii) halogen, and (viii) C (5) amino optionally mono or disubstituted with a substituent independently selected from the group consisting of (i) C (ii) C (iii) amino-C (iv) hydroxy-C (v) C (6) cyano, (7) halogen, (8) hydroxy, (9) C (10) aryl, (11) heteroaryl, (12) heterocyclyl, (13) —O— substituted with a substituent selected from the group consisting of (i) CF (ii) C (iii) aryl, (iv) heteroaryl, and (v) heterocyclyl, (14) heterocyclyl-SO (15) C(O) substituted with a substituent selected from the group consisting of (i) hydrogen, (ii) hydroxy, (iii) C (iv) C (v) amino optionally mono or disubstituted with a substituent independently selected from the group consisting of (16) amino-SO (i) C (ii) C (iii) amino-C (iv) hydroxy-C (v) heterocyclyl-C (vi) C (vii) aryl; and 2 Ar (1) C (2) C (3) C (4) C wherein each (1), (2), (3) and (4) is optionally substituted with one, two or three substituents independently selected from the group consisting of (i) C (ii) cyano, (iii) halogen, (iv) hydroxy, (v) C (vi) aryl, (vii) heteroaryl, (viii) heterocyclyl, wherein each (v), (vi), (vii) and (viii) is optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of (ix) amino optionally mono or disubstituted with a substituent independently selected from the group consisting of (x) C(O)amino optionally mono or disubstituted with a substituent independently selected from the group consisting of (5) NH, NHC(O), N, S, S(O), SO (i) hydrogen, (ii) C (iii) C (iv) amino-C (v) hydroxy-C (vi) aryl, (vii) heteroaryl, (viii) benzofused heteroaryl, (ix) C (x) heterocyclyl, xi) benzofused heterocyclyl, (xii) aryl-C (xiii) heteroaryl-C (xiv) benzofused heteroaryl-C (xv) C (xvi) heterocyclyl-C (xvii) benzofused heterocyclyl-C wherein each aryl, C (6) C(O) substituted with a substituent independently selected from the group consisting of (i) hydrogen, (ii) C (iii) C (iv) hydroxy, and (v) C (7) cyano, (8) halogen, (9) hydroxy, (10) nitro, (11) C (12) aryl, (13) heteroaryl, (14) benzofused heteroaryl, (15) heterocyclyl, and (16) benzofused heterocyclyl; wherein each (11), (12), (13), (14), (15) and (16) is optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of (i) C (ii) cyano, (iii) halogen, (iv) hydroxy, (v) nitro, (vi) C (vii) C (viii) aryl, (ix) aryl-C (x) heteroaryl, (xi) heteroaryl-C (xii) heterocyclyl, and (xiii) heterocyclyl-C