Patent ID: 6518266
Filing Date: 2003-02-11
Classification: A01N,C07D

Abstract:
A method of inhibiting a arthropod GABA receptor, comprising contacting one or more arthropod GABA receptors with one or more compounds of Formula I: or a salt thereof, whereR1 represents R5O, R5SO2, R5SO or R5S in which R5 is optionally halogen substituted C1-6 alkyl, optionally halogen substituted C2-6 alkenyl, optionally halogen substituted C2-6 alkynyl, (C3-7 cycloalkyl)methyl; or benzyl, optionally substituted by halo, hydroxy, methoxy or ethoxy; X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring selected from the group consisting of pyridyl, thienyl, furanyl, isoxazolyl, thiazolyl, isothiazolyl, indolizinyl, isoindolyl, indolyl, indazolyl, quinolizinyl, quinolinyl, and isoquinolinyl, wherein said 5- to 7-membered heteroaromatic ring is linked via a ring carbon on said 5- to 7-membered heteroaromatic ring, and wherein said optional substituents are selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, halogen, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkoxycarbonyl, nitro, amino, cyano, C1-4 alkylthio, C1-4 alkylsulfinyl and C1-4 alkylsulfonyl; R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; and R3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.