Patent ID: 7465710
Filing Date: 2008-12-16
Classification: A61K,C07K,H01L

Abstract:
1. A compound having the formula: wherein: A1 is a D or L-amino acid chosen from Cys, Leu, Dap, Trp, Gln, a tethered amino acid with an indole ring, Phe, Hyp, any Trp derivative; CαMe-Trp, CαMe-Gln, Des-amino-Trp, Pyr, Bth, Nal, Tcc, Asn, Nva, Abu, Tyr, Tic-OH, Tip, and Dip; A2 is a D or L-amino acid chosen from Cys, Trp, Arg, Nα-Me-Arg, CαMe-Arg, Orn, Cit, hArg(R)2, and Lys-ε-NH—R, where R is chosen from hydrogen, alkyl, aryl, aralkyl, and alkylaryl; A3 is a D or L-amino acid chosen from Glu, N-Me-Tyr, CαMe-Tyr, Tic-OH, Tic, Dip, Trp, Phe, des-carboxylic-Tyr (tyramine), and Tyr-(R), where R is hydrogen or a lipophilic group; n is 1, 2, or 3; and each bond between two amino acids or amino acid derivatives, represented by a dash (“—”), can be either a peptide bond or a pseudopeptide bond or a pharmaceutically acceptable salt thereof.