Patent ID: 8931490
Filing Date: 2015-01-13
Classification: A61K,A61N,A61P,Y10S

Abstract:
1. A method of nanomagnetic actuation of receptor-mediated signal transduction to control cellular behavior, the method comprising: adding monovalent paramagnetic nanoparticles to living cells to occupy cell surface receptors without activating the receptor, thereby creating bound nanoparticle-receptor complexes; applying a magnetic field to magnetize the paramagnetic nanoparticles in the nanoparticle-receptor complexes and to induce cohesion of the bound nanoparticle-receptor complexes; wherein said cohesion aggregates the bound nanoparticle-receptor complexes on a membrane of the living cells to produce receptor clusters that activate intracellular signaling responses only while the magnetic field is applied.