Patent ID: 8043821
Filing Date: 2011-10-25
Classification: G01N

Abstract:
1. A kit for performing an immunoassay to detect a C-reactive protein antigen in a test sample, the kit comprising a first monoclonal antibody and a second monoclonal antibody immobilized on a surface, the first antibody and the second antibody having a high specific affinity for the C-reactive protein antigen such that the first antibody and the second antibody form a ternary sandwich with the C-reactive protein antigen, wherein the first antibody and the second antibody do not exhibit substantial cross-reactivity with one another; wherein the percent specific activity of the ternary sandwich is from about 70% to about 99%, wherein the percent specific activity of the ternary sandwich is defined by the formula: wherein A is the ternary affinity value of the ternary sandwich; and C is the cross-reactivity value between the first antibody and the second antibody.