Patent ID: 6036959
Filing Date: 2000-03-14
Classification: A61K,A61P,C07K,C12N

Abstract:
A composition comprising:an isolated fusion protein comprising a non-cleavable Human Cytomegalovirus glycoprotein B (HCMVgB) fused at its amino terminus to the carboxy terminus of a portion of Herpes simplex virus type 2 glycoprotein D (HSV2 gD), wherein said HCMV gB comprises amino acids 28-686 of the gB of HCMV strain AD 169 wherein arginine 458 and arginine 459 are replaced by glutamine and threonine, respectively and wherein said portion of HSV2 gD is selected from the group consisting of amino acids 1-52, amino acids 1-25 and amino acids 26-52; anda pharmaceutically acceptable carrier.