Patent ID: 8110381
Filing Date: 2012-02-07
Classification: C12P

Abstract:
1. A method for producing an increased amount of L-glutamic acid as compared to the method using an unmodified Corynebacterium glutamicum , the method comprising A) culturing a modified B) collecting L-glutamic acid from the medium; wherein said Corynebacterium glutamicum is modified by decreasing expression of a gluX gene as compared to an unmodified Corynebacterium glutamicum by a method selected from the group consisting of: (i) introducing a mutation into said gluX gene, and (ii) disrupting said gluX gene, or an expression control region thereof, on the wherein said gluX gene encodes a protein selected from the group consisting of: (a) a protein comprising the amino acid sequence of SEQ ID NO: 17, and (b) a protein which is encoded by a nucleotide sequence which hybridizes with the nucleotide sequence of 1001 to 1279 of SEQ ID NO: 16 under stringent conditions comprising washing at 0.1×SSC, 0.1% SDS at 60° C.