Patent ID: 6663871
Filing Date: 2003-12-16
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
A method for generating a CD8+ T cell immune response in a mammal against at least one target antigen, comprising administering to said mammal at least one dose of each of the following:(i) a priming composition comprising a source of one or more CD8+ T cell epitopes of the target antigen; and (ii) a boosting composition comprising a source of one or more CD8+ T cell epitopes of the target antigen, including at least one CD8+ T cell epitope which is the same as a CD8+ T cell epitope of the priming composition, wherein the source of CD8+ T cell epitopes is a non-replicating or replication-impaired recombinant poxvirus vector in the mammal; with the proviso that if the source of epitopes in (i) is a viral vector, the viral vector in (ii) is derived from a different virus.