Patent ID: 6075014
Filing Date: 2000-06-13
Classification: A61K,A61P

Abstract:
A method of treating a .beta.-lactam-antibiotic-resistant bacterial infection comprising administering to an animal suffering from such an infectionan effective amount of a compound which is a .beta.-lactamase inhibitor, the compound having the formula: ##STR19## wherein: R is naphthalene, phenanthrene, or has one of the following formulas: ##STR20## wherein ring system (2), (4), (5), (6), (7), (8), (9), (10), (13) or (14) is aromatic or nonaromatic;the atom center * is (R) or (S) in the case of chiral compounds;positions 1, 2, 3, 4, 5, 6, 7 or 8 each independently is C, O or S;each R.sub.1 independently is a lone pair, H, B(OH).sub.2, a halogen atom, CF.sub.3, CH.sub.2 CF.sub.3, CCl.sub.3, CH.sub.2 CCl.sub.3, CBr.sub.3, CH.sub.2 CBr.sub.3, NO.sub.2, lower alkyl, CO.sub.2 H, CHCHCOOH, CH.sub.2 CH.sub.2 CH.sub.2 COOOH, SO.sub.3 H, PO.sub.3 H, OSO.sub.3 H, OPO.sub.3 H, OH, NH.sub.2, CONH.sub.2, COCH.sub.3, OCH.sub.3, or phenyl boronic acid;or a pharmaceutically-acceptable salt thereof; andan effective amount of a .beta.-lactam antibiotic.