Patent ID: 9107946
Filing Date: 2015-08-18
Classification: A61K,A61P,C07D

Abstract:
1. A combination of a PPAR-α agonist or a prodrug thereof and a DGAT inhibitor, wherein the DGAT inhibitor has the following formula or a stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —C(═O)—; —O—C(═O)—; —C(═O)—C(═O)—; —NR Z Y represents NR Z R R R R R R R R R R R aryl represents phenyl or phenyl substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl; carboxyl; halo; C aryl Het represents a monocyclic non-aromatic or aromatic heterocycle containing at least one heteroatom each independently selected from the group consisting of O, S, S(═O) Het p represents 1 or 2; provided that if X represents —O—C(═O)—, then R a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof.