Patent ID: 8389764
Filing Date: 2013-03-05
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of the formula I where X is —S(O) R1 is 1) hydrogen atom, 2) —(C 3) —(C 4) —(C R2 is a radical of the formula II in which m is the integer zero or 1, A1 is 1) —(CH 2) —NH—(CH 3) —NH(C 4) —NH((C 5) —O—(CH 6) —(CH A2 is 1) Het, where Het means a 4- to 15-membered heterocyclic ring system having 4 to 15 ring atoms which are present in one, two or three ring systems connected together, and which comprise one, two, three or four identical or different heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, and is unsubstituted or substituted independently of one another once, twice or three times by —(C 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C R3 is 1) —(C 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) hydrogen atom, R4 is —N(R6) where R6 are identical or different and are independently of one another 1) hydrogen atom, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C 15) —(C 16) amino acid, where the linkage of the amino acid takes place by a peptide linkage, and the carboxyl radical of the amino acid is unsubstituted or substituted by PG3 or by —N(R5) or the two R6 radicals form together with the N atom to which they are bonded a mono- or bicyclic ring having 4 to 9 ring atoms which is saturated, partly saturated or aromatic, where the ring is unsubstituted or substituted once or twice by —(C R5 is hydrogen atom or —(C PG1 is a protective group for the amino function, PG2 is a protective group for the hydroxy function, PG3 is a protective group for the carboxyl function, R7 is hydrogen atom or —(C R8 is hydrogen atom or —(C R9 is hydrogen atom or —(C R11 and R12 are identical or different and are independently of one another 1) hydrogen atom, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C R13 is 1) hydrogen atom, 2) —(C 3) —(C 4) —(C 5) —(C R14 is hydrogen atom, —(C R15 is hydrogen atom, —(C a stereoisomeric form of the compound of the formula I, or mixture of stereoisomeric forms in any ratio, or a physiologically tolerated salt of the compound of the formula I.