Patent ID: 6461870
Filing Date: 2002-10-08
Classification: A61B,A61K,G01N,Y10T

Abstract:
A method of diagnosing a condition in a subject, said condition in a subject, said condition selected from the group consisting of diabetes, insulin resistance, impaired glucose tolerance, impaired fasting glucose and gestational diabetes, said method comprising:a) collecting a first breath sample from said subject in a first breath collection container; b) administering 13C-enriched glucose to said subject; c) collecting a second breath sample from said subject in a second breath collection container at a time point after administration of said 13C-enriched glucose; d) measuring 13CO2 in each of said first and second breath samples; and e) comparing the amount of 13CO2 in said second breath sample with the amount of 13CO2 in said first breath sample to obtain a delta valve, wherein said comparison is made by choosing a delta cutoff of receiver oprated characteristics (ROC) values, wherein the sensitivity and specificity are such as to maximize diagnostic accuracy, and wherein the presence of less 13CO2 in said second breath sample compared to normal control values indicates the presence of said condition.