Patent ID: 6379692
Filing Date: 2002-04-30
Classification: A61K,A61P,Y10S

Abstract:
A method of preparing a pharmaceutical formulation for administering to a patient in need thereof a pharmacologically active ingredient which is sparingly soluble in water at the pH acceptable for administration, comprising providing the active ingredient in solution in a pharmacologically-acceptable base, mixing the resulting solution with a pharmacologically-acceptable acid in an amount such that the formulation attains a pH in the range of from about 3.5 to about 8.5, forming therefrom by precipitation a suspension of the active ingredient in which the active ingredient has a mean particle size in the range of from 2 to 10 &mgr;m (number) or 4 to 15 &mgr;m (volume) and a D90 (as herein before defined) of the order of 5 to 10 &mgr;m (number), and incorporating a viscosity-enhancing agent in the formulation prior to or during the mixing with acid.