Patent ID: 7732400
Filing Date: 2010-06-08
Classification: A61K,A61P,G01N

Abstract:
1. A method for treating a diabetic subject who has (a) undergone an angioplasty procedure comprising placing an angioplasty balloon in a blood vessel and (b) experienced an injury in the blood vessel which comprises administering to the subject a soluble fragment of a receptor for advanced glycation endproduct polypeptide, which fragment (a) includes an amyloid-beta peptide-binding portion of receptor for advanced glycation endproduct polypeptide and (b) is coupled to an antibody, in an amount effective to reduce smooth muscle proliferation and migration in the subject's blood vessels, so as to thereby treat the subject, wherein the sequence of the receptor for advanced glycation endproduct polypeptide is set forth in SEQ ID NO:1, 3, or 5, and wherein the blood vessel is a carotid artery.