Patent ID: 6365125
Filing Date: 2002-04-02
Classification: C07B,C07D

Abstract:
In a process for producing radioiodinated neuroreceptor compounds from a precursor compound of the formula: wherein the substituents R1 are the same or different and are CnH2n+1 groups, wherein n is from 1 to 6, or an aryl group;by replacing the trialkyl tin group of the precursor compound with a radioactive iodine group in the presence of an oxidation agent; the improvement comprising replacing the trialkyl tin group with a radioactive iodine group in the presence of an oxidation in a pH range which is adjusted with a buffering system to be between 4 and 7 using a buffering agent selected from the group consisting of phosphoric acid, organic acids, and their salts and mixtures thereof.