Patent ID: 6573263
Filing Date: 2003-06-03
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula in whichR1 denotes phenyl, naphthyl, quinolinyl or isoquinolinyl, each of which can be substituted up to three times identically or differently by radicals selected from the group consisting of (C1-C4)-alkyl, (C1-C4)-alkoxy, halogen, cyano, â€”NHCOR8, â€”NHSO2R9, â€”SO2NR10R11, â€”SO2R12, and â€”NR13R14, in which R8, R10, R11, R13 and R14 independently of one another are hydrogen or (C1-C4)-alkyl, and R9 and R12 independently of one another are (C1-C4)-alkyl, or R10 and R11 together with the adjacent nitrogen atom form an azetidin-1-yl, pyrrol-1-yl, piperid-1-yl, azepin-1-yl, 4-methyl-piperazin-1-yl or morpholin-1-yl radical, or R13 and R14 together with the adjacent nitrogen atom form an azetidin-1-yl, pyrrol-1-yl, piperid-1-yl, azepin-1-yl, 4-methyl-piperazin-1-yl or morpholin-1-yl radical, R2 and R3 independently of one another denote hydrogen or fluorine, R4 denotes (C1-C4)-alkyl, R5 denotes (C1-C3)-alkyl, R6 denotes hydrogen or methyl, R7 denotes phenyl, thiophenyl, furanyl, each of which can be substituted up to three times identically or differently by radicals selected from the group consisting of (C1-C4)-alkyl, (C1-C4)-alkoxy, halogen and cyano, or denotes (C5-C8)-cycloalkyl, L denotes carbonyl or hydroxymethanediyl, and M denotes (C2-C5)-alkanediyl, (C2-C5)-alkenediyl or alkinediyl, or a physiologically tolerable salt thereof.