Patent ID: 8927697
Filing Date: 2015-01-06
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody selected from: a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 10 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090902; b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO: 8 and SEQ ID NO: 10; or c) a bispecific, humanized, single-chain, chimeric, synthetic or recombinant antibody that binds PD-1 comprising a light chain variable region comprising SEQ ID NO: 21 (light chain CDR1), SEQ ID NO: 22 (light chain CDR2), SEQ ID NO: 23 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO: 24 (heavy chain CDR1), SEQ ID NO: 25 (heavy chain CDR2) and SEQ ID NO: 26 (heavy chain CDR3).