Patent ID: 9211419
Filing Date: 2015-12-15
Classification: A61K,A61N,A61P

Abstract:
1. A method for the treatment of a tumor residing in a target area of an organism comprising: introducing a plurality of nanoparticles into a circulating blood of an organism; allowing the nanoparticles to preferentially accumulate in the target area; applying an external energy to the target area wherein the nanoparticles are adapted to transduce at least a portion of the external energy into heat energy, wherein the external energy is electromagnetic energy; wherein the electromagnetic energy is selected from the group consisting of ultraviolet light, visible light, infrared light, microwaves, and a combination thereof; wherein the heat energy causes a rise in temperature in the target area; allowing the temperature of the target area to elevate to a localized elevated temperature by way of a transduction of the external energy into heat energy by the nanoparticles, wherein the localized elevated temperature is non-ablative, wherein the localized elevated temperature increases perfusion and/or reduces hypoxia of the tumor; and applying ionizing radiation to the target area at a time during the increased perfusion and/or the reduced hypoxia.