Patent ID: 6555685
Filing Date: 2003-04-29
Classification: A61P,C07D

Abstract:
A process for the production of a compound of formula (I): wherein X is H, OH or halo; and R1 and R2 are selected independently from C1-12 alkyl, aryl, C1-2 alkylaryl, C1-12 alkylsilyl, arylsilyl and C1-12 alkyldiarylsilyl, or R1 and R2 are joined together to form a moiety of the formula: wherein R3 and R4 are selected independently from H, C1-12 alkyl and aryl, which method comprises reacting a compound of formula (II): wherein X is as defined for formula (I), with a compound of formula (III): wherein Y is a leaving group and R1 and R2 are as defined for formula (I), in the presence of a palladium(0) catalyst and a ligand.