Patent ID: 6635628
Filing Date: 2003-10-21
Classification: A61K

Abstract:
A method of inhibiting a diarrhea side effect in a patient receiving a treatment with a camptothecin compound, the method comprising:administering a camptothecin compound selected from the group consisting of irinotecan hydrochloride CPT-11-Glu, SN-38-Glu, SN-38, 10,11-methylenedioxy-20(RS)-camptothecin, 9-amino-20(RS)-camptothecin and 7-hydroxy-methyl camptothecin in the amount of 10 mg/m2 to 700 mg/m2 to a patient in need thereof while maintaining the intestinal lumen of the patient at an alkaline pH of 7 to 10 by administering urso-deoxycholic acid to the patient to stimulate bicarbonate secretion into bile of the patient.