Patent ID: 6395257
Filing Date: 2002-05-28
Classification: A61K,C09B

Abstract:
A method for performing a diagnostic or therapeutic procedure which comprises administering to an individual an effective amount of the composition of an indocyanine dye of the formula wherein a6 varies from 0 to 5; W6 and X6 may be the same or different and are selected from the group consisting of â€”CR10R11, â€”Oâ€”, â€”NR12, â€”Sâ€”, and â€”Se; Y6 and Z6 may be the same or different and are selected from the group consisting of â€”(CH2)câ€”CO2H, â€”CH2â€”(CH2â€”Oâ€”CH2)dâ€”CH2â€”CO2H, â€”(CH2)eâ€”NH2, â€”CH2â€”(CH2â€”OCH2)fCH2NH2, (CH2)gâ€”N(R14)â€”(CH2)hâ€”CO2H, and â€”(CH2)iâ€”N(R15)â€”CH2â€”(CH2â€”Oâ€”CH2)jâ€”CH2â€”CO2H; A4 is a single or a double bond; if A, is a single bond, then B4 and C4 may the same or different and are selected from the group consisting of â€”Oâ€”, â€”S, â€”Seâ€”, â€”Pâ€” and â€”NR38 and D4 is selected from â€”CR39R40 and â€”C&boxH;O; if A4 is a double bond, then B4 is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”Seâ€”, â€”Pâ€” and â€”NR38, C4 is selected from nitrogen and â€”CR41 and D is â€”CR42, R67 to R79 may be the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, hydrophilic peptide, C1-C10 aryl, hydroxyl, C1-C10 polyhydroxyalkyl, C1-C10 alkoxyl, cyano, nitro, halogen, and â€”NR43R44, R10 to R12, R14 and R15 may be the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, C1-C10 aryl, C1-C10 alkoxyl, C1-C10 polyalkoxyalkyl, â€”CH2(CHâ€”Oâ€”CH2)câ€”CH2â€”OH, C1-C20 polyhydroxyalkyl, C1-C10 polyhydroxyaryl, â€”(CH2)dCO2H, â€”CH2â€”(CH2â€”Oâ€”CH2)eâ€”CH2â€”CO2H, â€”(CH2)fNH2 and â€”CHâ€”(CH2â€”Oâ€”CH2)gâ€”CH2NH2, R38 to R42 may be same or different and are selected from the group consisting of -hydrogen, C1-C10 alkyl, C1-C10 aryl, C1-C10 alkoxyl, C1-C10 polyalkoxyalkyl, â€”CH2(CHâ€”Oâ€”CH2)câ€”CH2â€”OH, C1-C20 polyhydroxyalkyl, C1-C10 polyhydroxyaryl, â€”(CH2)dCO2H, CH2(CH2â€”Oâ€”CH2)eâ€”CH2â€”CO2H, â€”(CH2)fNH2, and â€”CH2â€”(CH2â€”Oâ€”CH2)gâ€”CH2â€”NH2; c, e, g, h, and i vary from 1 to 10; d, f and j vary from 1 to 100; and R43 and R44 may be the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, and C1-C10 aryl, or may together form a 5, 6, or 7 membered carbocyclic ring or a 5, 6, or 7 membered heterocyclic ring optionally containing one or more oxygen, nitrogen, or sulfur atoms, said composition in a pharmaceutically suitable carrier.