Patent ID: 7585974
Filing Date: 2009-09-08
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 5-[2-(2,4-dimethoxy-5-pyrimidinyl)-pyridin-5-yl]-1-azabicyclo[3.2.1]oct-2-ene hydrobromide (2:1); 5-[2-(3,4-dimethoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(3,4-dimethoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(2-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3-methylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3-nitrophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3-trifluoromethylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(4-methylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(1,3-benzodioxol-5-yl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(4-chlorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 1-{3-[5-(1-azabicyclo[3.2.1]oct-3-en-5-yl)pyridin-2-yl]phenyl}ethanone ethanedioate (1:1); 5-[2-(3-pyridinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(5-indolyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(4-methoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(3,5-dimethylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(4-pyridinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene ethanedioate (1:1); 5-[2-(4-methoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(4-methylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-methylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3,5-dimethylphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(1,3-benzodioxol-5-yl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(2-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-pyridinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(4-pyridinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-nitrophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-trifluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-bromopyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-bromopyridin-5-yl]-1-azabicyclo[3.2.1]oct-2-ene hydrobromide (2:1); 5-[2-(4-piperidinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-piperidinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); (+)-5-[2-(4-methoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane; (−)-5-[2-(4-methoxyphenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane; (+)-5-[2-(3-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane; (−)-5-[2-(3-fluorophenyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane; 5-[2-(2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(5-methyl-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(5-methyl-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(5-chloro-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(5-chloro-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(2-furyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(2-furyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(5-indolyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1); 5-[2-(2-benzofuryl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene; 5-[2-(2-benzofuryl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(2-pyrrolyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(2-pyrrolyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1); 5-[2-(2-benzothienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene; 5-[2-(2-benzothienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3-furyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(3-furyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(4-hydroxy-3-pyridinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane; 5-[2-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(2,4-dimethoxypyrimidin-5-yl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1); 5-[2-(4-methyl-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(4-methyl-2-thienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(1-dibenzofuryl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(1-dibenzofuryl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(1-phenoxatiinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(1-phenoxatiinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(8-quinoleinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane hydrobromide (2:1); 5-[2-(8-quinoleinyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(3-benzothienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]oct-3-ene hydrobromide (2:1); 5-[2-(3-benzothienyl)pyridin-5-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1).