Patent ID: 7384759
Filing Date: 2008-06-10
Classification: C07K,C12N,C12Q,G01N,G16B

Abstract:
1. A method of screening compounds to determine those which are inhibitors of a chalcone O-methyltransferase, said method comprising: (a) contacting a potential compound that fits an active site of said chalcone O-methyltransferase based on a plurality of atomic coordinates of the three-dimensional structure thereof according to Table 5, wherein said active site is defined by the coordinates of residues 25, 27-29, 32, 33, 132, 135, 138, 139, 185, 189, 192, 278, 307, 321, 325, 326, 328, 329, 332 and 333 of SEQ ID NO:2; and (b) determining the ability of said compound to inhibit the O-methylation enzymatic activity of said chalcone O-methyltransferase, whereby those compounds which inhibit the activity of O-methyltransferase are identified as inhibitors therefor.