Patent ID: 6515106
Filing Date: 2003-02-04
Classification: A61K,A61P,C12N

Abstract:
An antibiotic polypeptide comprising a modified T4 lysozyme, which exhibits antibiotic activity but which does not exhibit muramidase activity, wherein said antibiotic polypeptide consists of:(1) at least one fragment selected from the group consisting of: (a) amino acids 143-155 of SEQ ID NO: 1; and (b) amino acids 126-141 of SEQ ID NO: 1, with or without mutation at positions 140 and/or 141 of SEQ ID NO: 1; and (2) does not include the entire amino acid sequence SEQ ID NO: 1; and wherein the antibiotic polypeptide consists of (a) amino acids 12-164 of SEQ ID NO: 1; (b) amino acids 12-164 of SEQ ID NO: 1, with one or more mutations at any one or more of positions 140-142 of SEQ ID NO: 1; (c) amino acids 126-141 of SEQ ID NO: 1; (d) amino acids 126-141 of SEQ ID NO: 1, with one or more mutations at any one or more of positions 140-141 of SEQ ID NO: 1; (e) amino acids 143-155 of SEQ ID NO: 1; (f) amino acids 74-164 of SEQ ID NO: 1; (g) amino acids 74-164 of SEQ ID NO: 1, with one or more mutations at any one or more of positions 140-142 of SEQ ID NO: 1; (h) amino acids 114-164 of SEQ ID NO: 1; (i) amino acids 114-164 of SEQ ID NO: 1, with one or more mutations at any one or more of positions 140-142 of SEQ ID NO: 1; or (j) amino acids 124-164 of SEQ ID NO: 1.