Patent ID: 8119614
Filing Date: 2012-02-21
Classification: A61K,A61P,A61Q,C07H

Abstract:
1. A therapeutic composition containing substitution derivatives of N 6 -benzyladenosine, selected from the group comprising 6-(2-acetylbenzylamino)purine riboside, 6-(3-acetylbenzylamino)purine riboside, 6-(4-acetylbenzylamino)purine riboside, 6-(2-acetoxybenzylamino)purine riboside, 6-(3-acetoxybenzylamino)purine riboside, 6-(4-acetoxybenzylamino)purine riboside, 6-(2-sulphobenzylamino)purine riboside, 6-(3-sulphoobenzylamino)purine riboside, 6-(4-sulphobenzylamino)purine riboside, 6-(4-methylaminobenzylamino)purine riboside, 6-(4-hexylbenzylamino)purine riboside, 6-(4-hexyloxybenzylamino)purine riboside, 6-(2-formylbenzylamino)purine riboside, 6-(3-formylbenzylamino)purine riboside, 6-(4-formylbenzylamino)purine riboside, 6-(2-ethoxybenzylamino)purine riboside, 6-(3-ethoxybenzylamino)purine riboside, 6-(4-ethoxybenzylamino)purine riboside, 6-(4-ethylbenzylamino)purine riboside, 6-(4-pentylbenzylamino)purine riboside, 6-(4-pentyloxybenzylamino)purine riboside, 6-(4-phenoxybenzylamino)purine riboside, 6-(4-propylbenzylamino)purine riboside, 6-(4-propyloxybenzylamino)purine riboside, 6-(4-octylbenzylamino)purine riboside, 6-(4-octyloxybenzylamino)purine riboside, 6-(2,5-diaminobenzylamino)purine riboside, 6-(2,5-dihydroxybenzylamino)purine riboside, 6-(2,6-dihydroxybenzylamino)purine riboside, 6-(2-hydroxy-3-methoxybenzylamino)purine riboside, 6-(2-hydroxy-4-methoxybenzylamino)purine riboside, 6-(2-hydroxy-5-methoxybenzylamino)purine riboside, 6-(2-hydroxy-6-methoxybenzylamino)purine riboside, 6-(3-hydroxy-2-methoxybenzylamino)purine riboside, 6-(3-hydroxy-4-methoxybenzylamino)purine riboside, 6-(3-hydroxy-5-methoxybenzylamino)purine riboside, 6-(3-hydroxy-6-methoxybenzylamino)purine riboside, 6-(4-hydroxy-2-methoxybenzylamino)purine riboside, 6-(4-hydroxy-3-methoxybenzylamino)purine riboside, 6-(4-hydroxy-5-methoxybenzylamino)purine riboside, 6-(4-hydroxy-6-methoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,5-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,6-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,5-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,6-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-5,6-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-4,5-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-4,6-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,4-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,5-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,6-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,3-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,5-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,6-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-3,5-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-3,6-dimethoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-2-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-2-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4,5-trimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4,6-trimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,5,6-trimethoxybenzylamino)purine riboside, 6-(2,3,4-trihydroxybenzylamino)purine riboside, 6-(2,4,6-trihydroxybenzylamino)purine riboside, 6-(2,3,4-trihydroxybenzylamino)purine riboside, 6-(3,4,5-trihydroxybenzylamino)purine riboside, 6-(2,4,6-tri hydroxybenzylamino)purine riboside, 6-(2-hydroxy-3-chlorobenzylamino)purine riboside, 6-(2-hydroxy-4-chlorobenzylamino)purine riboside, 6-(2-hydroxy-5-chlorobenzylamino)purine riboside, 6-(2-hydroxy-6-chlorobenzylamino)purine riboside, 6-(2-hydroxy-3-iodobenzylamino)purine riboside, 6-(2-hydroxy-4-iodobenzylamino)purine riboside, 6-(2-hydroxy-5-iodobenzylamino)purine riboside, 6-(2-hydroxy-6-iodobenzylamino)purine riboside, 6-(2-hydroxy-3-bromobenzylamino)purine riboside, 6-(2-hydroxy-4-bromobenzylamino)purine riboside, 6-(2-hydroxy-5-bromobenzylamino)purine riboside, 6-(2-hydroxy-6-bromobenzylamino)purine riboside, 6-(2-hydroxy-3-fluorobenzylamino)purine riboside, 6-(2-hydroxy-4-fluorobenzylamino)purine riboside, 6-(2-hydroxy-5-fluorobenzylamino)purine riboside, 6-(2-hydroxy-6-fluorobenzylamino)purine riboside, 6-(2-hydroxy-3-methylbenzylamino)purine riboside, 6-(2-hydroxy-4-methylbenzylamino)purine riboside, 6-(2-hydroxy-5-methylbenzylamino)purine riboside, 6-(2-hydroxy-6-methylbenzylamino)purine riboside, 6-(2,3-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,3-dihydroxy-5-chlorobenzylamino)purine riboside, 6-(2,5-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-4-bromoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-4-iodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-bromobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-iodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-fluorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-dichlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-dibromobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-diiodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-difluorobenzylamino)purine riboside, and their pharmaceutically acceptable salts with alkali metals, ammonium or amines, in the form of racemates or optically active isomers, as well as their addition salts with acids.