Patent ID: 6368808
Filing Date: 2002-04-09
Classification: B01J,B82Y,C12Q,C40B

Abstract:
An element comprising a solid carrier and a nucleotide derivative or analogue thereof selected from the group consisting of oligonucleotides, polynucleotides and peptide-nucleotides which are fixed to the solid carrier via covalent bonding, in which the covalent bonding is produced by a reaction between a first reactive group attached to the solid carrier and asecond reactive group attached to the nucleotide derivative or analogue in the presence of a transition metal-containing catalyst, in which the first reactive group is selected from the group consisting of a residue of an alkylboronic acid, a residue of an alkenylboronic acid and a residue of an arylboronic acid and the second reactive group is selected from the group consisting of a residue of an alkenyl halide and an aryl halide, or in which the first reactive group is selected from the group consisting of a residue of an alkenyl halide and an aryl halide and the second reactive group is selected from the group consisting of a residue of an alkylboronic acid, a residue of an alkenylboronic acid and a residue of an arylboronic acid.