Patent ID: 9198888
Filing Date: 2015-12-01
Classification: A61K,A61P

Abstract:
1. A method of reducing the incidence of NSAID-associated gastric ulcers in a patient requiring NSAID treatment for osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, and who is at risk of developing an NSAID-associated ulcer, wherein the method comprises administering to said patient a therapeutically effective amount of a pharmaceutical composition in unit dosage form comprising: (a) esomeprazole or a pharmaceutically acceptable salt thereof wherein, upon introduction of said unit dosage form into a medium, said esomeprazole or a pharmaceutically acceptable salt thereof is released regardless of the pH of the medium; and (b) naproxen surrounded by coating that does not dissolve until the surrounding medium is at a pH of at least 3.5.