Patent ID: 8114887
Filing Date: 2012-02-14
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): or its tautomer (I′) wherein: X is N; X′ is NH; Z is O; R wherein n is 0, 1 or 2; R R 3 is selected from the group consisting of (2) —C and said R Q R 4 and R 4′ are selected from the group consisting of (1) hydrogen, (2) —C (3) —C (4) —C R 5 is selected from the group consisting of (1) hydrogen, (2) —C (3) halogen, and (4) —CO R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are independently selected from the group consisting of: (1) hydrogen, (2) —C (3) —C (4) —C wherein said alkyl is optionally substituted with one or more and said cycloalkyl and aryl are optionally substituted with one or more provided that when X is N; Z is O; and R 2 is unsubstituted phenyl, then R 3 is not unsubstituted benzyl; and pharmaceutically acceptable salts thereof, and individual enantiomers and diastereomers thereof.