Patent ID: 6420424
Filing Date: 2002-07-16
Classification: A61K,A61P

Abstract:
A method of antagonizing a CCR-3 receptor by administering a compound selected from Formula (I) or Formula (II) hereinbelow: whereinn is an integer from 0 to 3; R1 is selected from the group consisting of N-carbobenzoxy-L-Phe, N-Ac-L-Pro, C1-6 alkyl, OC1-4 alkyl, aryl and heteroaryl, unsubstituted, monosubstituted, disubstitututed or trisubstituted, with any substituents being independently selected from the group consisting of C1-4 alkyl, COaryl, OCH2O, NO2, Cl and OCH3. R2 represents C1-4 alkyl or benzyl; m is an integer from 1 to 3; and R3 is independently selected from the group consisting of OH, OC1-4 alkyl, NO2, NH2, halo, naphthyl, and OCOphenyl; or â€ƒwherein R represents indolylmethyl, phenyl or (CH2)2phenyl.