Patent ID: 6984738
Filing Date: 2006-01-10
Classification: C07C,Y02P

Abstract:
1. A process for producing an optically active amino alcohol represented by the following formula (2) wherein R 1 is a hydrocarbon group, a substituted hydrocarbon group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R 2 and R 3 each independently is hydrogen atom, a hydrocarbon group, a substituted hydrocarbon group, an acyl group, an acyloxy group, an alkyloxycarbonyl group, an aralkyloxycarbonyl group, an aryloxycarbonyl group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R 4 hydrogen atom or a protective group; two or more of R 1 , R 2 , R 3 and R 4 may be bonded to each other to form a ring; and * is asymmetric carbon, provided that when R 2 or R 3 is hydrogen atom, the carbon atom to which R 2 or R 3 is bonded is not an asymmetric carbon, or a salt thereof, which comprises subjecting a compound represented by the following formula (1) or a salt thereof to an asymmetric hydrogenation reaction in the presence of an asymmetric metal complex wherein formula (1) is: wherein R 1 is a hydrocarbon group, a substituted hydrocarbon group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R 2 and R 3 each independently is hydrogen atom, a hydrocarbon group, a substituted hydrocarbon group, an acyl group, an acyloxy group, an alkyloxycarbonyl group, an aralkyloxycarbonyl group, an aryloxycarbonyl group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R 4 is hydrogen atom or a protective group; two or more of R 1 , R 2 , R 3 and R 4 may be bonded to each other to form a ring; and the double bond between the carbon atoms to which R 2 and R 3 are attached is cis or trans or a mixture thereof.