Patent ID: 7632940
Filing Date: 2009-12-15
Classification: A61P,C07H

Abstract:
1. A process for the preparation of 4′-azido-cytidine (I) or of a pharmaceutically accepted salt thereof, comprising the steps of: a) contacting a 4′-azido-nucleoside of the formula II wherein: R R R with imidazole, phosphorous oxychloride and triethylamine, optionally in the presence of a first organic solvent, to form an imidazole compound of formula IIIa wherein R 1 , R 2 and R 3 are as above; b) contacting the compound of formula IIIa with aqueous ammonia and a second organic solvent to form an amine of formula IIIb; wherein R 1 , R 2 and R 3 are as above; and, c) deprotecting the amine of formula IIIb to afford 4′-azido-cytidine (I).