Patent ID: 6387955
Filing Date: 2002-05-14
Classification: A61K

Abstract:
A method for treating a medical condition which involves angiogenesis in a subject, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a pharmaceutical composition having anti-angiogenic activity which contains as an active ingredient a therapeutically effective quantity of a compound of the formula (I): wherein:Y is a non-toxic pharmaceutically acceptable anion; DRUG is a radical selected from the group consisting of a steroid agonist or antagonist, a mixed agonist-antagonist, and a partial agonist; X is a direct bond or a radical selected from the group consisting of â€”Oâ€”; â€”NHâ€”; â€”NRâ€”, wherein R is an alkyl or aryl group with less than ten carbons; â€”PO3â€”; â€”Sâ€”; â€”SOâ€”; and â€”SO2â€”; R1 and R2 are the same or different and may be a radical selected from the group consisting of H, an alkyl of 1-10 carbon atoms, an arylalkyl of 7-16 carbons, and an aryl; R3, R4 and R5 are independently a radical selected from the group consisting of a branched or unbranched, cyclic or noncyclic, alkyl of 1-10 carbon atoms; an alkyl of up to 10 carbon atoms substituted by a carboxy, hydroxy, alkoxy, halo, or nitro group; a branched or unbranched, cyclic or noncyclic arylalkyl of 7-16 carbon atoms; and an aryl; and n is 0-12.