Patent ID: 6207815
Filing Date: 2001-03-27
Classification: A61K,A61P,C07K

Abstract:
A DNA sequence encoding a chimeric antibody heavy chain or a chimeric antigen-binding fragment thereof, said heavy chain having the amino acid sequence of a chimeric antibody heavy chain produced by any one of the cell lines CH44-1 (ATCC HB9884), CH44-2 (ATCC HB 9880), CH44-4 (ATCC HB 9877), CH88-1 (ATCC HB 9882), CH88-2 (ATCC HB 9881), CH88-3 (ATCC HB 9876), CH88-4 (ATCC HB9874), CH84-1 (ATCC HB 9883), CH84-2 (ATCC HB 9879), CH84-3 (ATCC HB 9878), or CH84-4 (ATCC HB 9875), the heavy chain having the ability to combine with an anti-TAG-72 antibody light chain to form a binding site having an affinity for TAG-72 which is at least 25% greater than that of the binding site of B72.3.