Patent ID: 7754426
Filing Date: 2010-07-13
Classification: C12Q

Abstract:
1. A method for identifying the type of glioblastoma multiforme in a human subject, comprising the steps of: obtaining a test sample comprising a cell-containing material from the brain of the human subject, determining the expression levels of Achaete-scute complex-like 1 gene (ASCL1) having SEQ ID NO: 3, Hairy and Enhancer of Split 1 gene (HES1) having SEQ ID NO: 1, and Hairy and Enhancer of Split 6 gene (HES6) having SEQ ID NO: 5 in the test sample and in a control sample, comparing the expression level of the ASCL1, and HES1, and HES6 genes in the test sample with the expression level of the ASCL1, HES1, and HES6 genes in the control sample; wherein an increase in the expression level of ASCL1 gene, an increase in the expression level of HES6 gene, and a decrease in the expression level of HES1 gene in the test sample as compared to the control sample indicates the presence of a secondary glioblastoma multiforme.