Patent ID: 6346422
Filing Date: 2002-02-12
Classification: A61K,A61P,G01N

Abstract:
A method for screening nonpathogenic bacterial strains for their ability to bind to host tissue receptor sites specific for pathogenic bacterial strains whose pathogenicity to the animal is mediated by tissue adhesion, said method comprising the steps of:a) bringing the host tissue receptor sites into contact in vitro with a nonpathogenic bacterial strain; b) adding an antibody directed against the receptor sites; c) labeling the antibody in a detectable manner, before or after the step of adding the antibody; and d) detecting for the presence of a complex formed between the antibody and the receptor sites; whereby, the fewer of said complexes detected compared with a total antibody binding control, the greater the ability of said nonpathogenic bacterial strain to bind to said host receptor sites.