Patent ID: 8410267
Filing Date: 2013-04-02
Classification: A61P,C07D

Abstract:
1. A method for regioselectively reducing a compound of formula (I) into a compound of formula (II): wherein: ring B, together with the carbon atoms to which it is attached, is selected from: R at least one of R the other R Q is selected from an optionally substituted C R R R R R R R R R R R R R p is independently selected from 1, 2, 3, and 4; x is 0 or 1; or a stereoisomer or salt form thereof, said method comprising the steps of: i) contacting said compound of formula (I) with a metal hydride together with an activating agent selected from a mineral, organic or Lewis acid in a solvent; and optionally ii) recovering the obtained compound of formula (II) or a stereoisomer or salt form-thereof.