Patent ID: 6156757
Filing Date: 2000-12-05
Classification: A61P,C07D

Abstract:
A compound of formula ##STR21## a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein:each R.sup.1 is independently hydrogen, halogen, C.sub.1-6 alkyl, nitro, hydroxy or C.sub.1-4 alkyloxy;Alk is C.sub.1-6 alkanediyl;n is 1 or 2;D is a radical of formula ##STR22## wherein each X independently represents O, S or NR.sup.12 ;R.sup.2 is hydrogen, C.sub.1-6 alkyl, aryl or arylC.sub.1-6 alkyl;R.sup.3 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, C.sub.1-6 alkylthio, amino or mono- or di(C.sub.1-6 alkyl)amino;R.sup.4, R.sup.7, R.sup.11 and R.sup.12 each independently are hydrogen or C.sub.1-6 alkyl; orR.sup.3 and R.sup.4 taken together may form a bivalent radical --R.sup.3 --R.sup.4 -- of formula--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-1);--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-2);--CH.dbd.CH--CH.sub.2 -- (a-3);--CH.sub.2 --CH.dbd.CH-- (a-4)or--CH.dbd.CH--CH.dbd.CH-- (a-5);wherein one or two hydrogen atoms of said radicals (a-1) to (a-5) each independently may be replaced by halo, C.sub.1-6 alkyl, arylC.sub.1-6 alkyl, trifluoromethyl, amino, hydroxy, C.sub.1-6 alkyloxy or C.sub.1-10 alkylcarbonyloxy; or where possible, two geminal hydrogen atoms may be replaced by C.sub.1-6 alkylidene or arylC.sub.1-6 alkylidene; or--R.sup.3 --R.sup.4 -- may also be--S--CH.sub.2 --CH.sub.2 -- (a-6);--S--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-7);--S--CH.dbd.CH-- (a-8);--NH--CH.sub.2 --CH.sub.2 -- (a-9);--NH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-10);--NH--CH.dbd.CH-- (a-11);--NH--CH.dbd.N-- (a-12);--S--CH.dbd.N-- (a-13)or--CH.dbd.CH--O-- (a-14);wherein one or where possible two or three hydrogen atoms in said radicals (a-6) to (a-14) each independently may be replaced by C.sub.1-6 alkyl or aryl; andaryl is phenyl or phenyl substituted with halo or C.sub.1-6 alkyl.