Patent ID: 6046189
Filing Date: 2000-04-04
Classification: C07D

Abstract:
A compound represented by the formula (I'): ##STR64## wherein G' represents a halogen atom; M' representsa hydrogen atom,a hydrocarbon group which is unsubstituted or substituted by halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, a hydrocarbon group, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl,an acyl group which is unsubstituted or substituted by halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, a hydrocarbon group, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl,a carbamoyl group, which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl,a thiocarbamoyl group which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl, ora sulfonyl group which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl;n is 0 or 1;R representsa 5- to 7-membered heterocyclic ring containing one sulfur atom, nitrogen atom, or oxygen atom which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, oxo, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl, oran amino group represented by --N(R.sup.1)(R.sup.2) in which R.sup.1 and R.sup.2 are the same or different and are a hydrogen atom; a hydrocarbon group which is unsubstituted or substituted by halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, a hydrocarbon group, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl; an acyl group; a sulfonyl group; or a 5- to 7-membered heterocyclic ring containing one sulfur atom, nitrogen atom, or oxygen atom which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl; or R.sup.1 and R.sup.2 may bind to each other to form a 5- to 7-membered heterocyclic ring containing one nitrogen atom, which is unsubstituted or substituted by a hydrocarbon group, halogen, amino, acyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyloxy, aryloxy, thio, alkylthio, alkenylthio, alkynylthio, aralkylthio, acylthio, arylthio, carboxyl, oxo, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aralkyloxycarbonyl, acyloxycarbonyl, or aryloxycarbonyl;X is (--CH.sub.2 --).sub.q and q is an integer from 0 to 5;the ring A is unsubstituted or substituted bya halogen atom,a nitro group,an alkyl group,a hydroxy group which is unprotected or protected by a protecting group,a thiol group which is unprotected or protected by a protecting group,an amino group which is unsubstituted or substituted by alkyl, alkenyl, alkynyl, aryl, or acyl,an acyl group,a carboxyl group,an alkyloxycarbonyl group,an alkenyloxycarbonyl group,an alkynyloxycarbonyl group,an aralkyloxycarbonyl group,an acyloxycarbonyl group,an aryloxycarbonyl group,an aromatic hydrocarbon group, ora heteroaryl selected from the group consisting of pyridyl, furyl, thienyl, imidazolyl, and thiazolyl;the ring B represents a 6-membered ring containing a nitrogen atom; or a pharmaceutically acceptable salt thereof.