Patent ID: 7531537
Filing Date: 2009-05-12
Classification: A61P,C07D

Abstract:
1. A benzofuran derivative of the formula [1]: wherein X is a group of the formula: —N— Y is a cycloalkyl group optionally substituted by a group selected from (i) an amino group optionally substituted by a group selected from the following: (1) a lower alkyl group; (2) a cycloalkyl group, (3) a hydroxy-lower alkyl group, (4) a lower alkyl group substituted by an amino group optionally substituted by a group selected from (a) a lower alkyl group, (b) a lower alkanoyl group, (c) a lower alkanoyl group substituted by an amino group substituted by a lower alkyl group, and (d) a lower alkoxycarbonyl group, (5) a lower alkyl group substituted by a cyano group, (6) a lower alkyl group substituted by a lower alkoxycarbonyl group, (7) a lower alkyl group substituted by a carboxyl group, (8) a lower alkyl group substituted by a carbamoyl group optionally substituted by a lower alkyl group, (9) a lower alkyl group substituted by an aryl group, (10) a lower alkoxycarbonyl group, (11) a lower alkanoyl group substituted by a di-lower alkyl amino group, (12) a lower alkanoyl group, (13) a lower alkylsulfonyl group, (14) a carbamoyl group substituted by a lower alkyl group, (15) a carbonyl group substituted by an aryl group, (16) a lower alkanoyl group substituted by a lower alkoxy group, (17) a lower alkanoyl group substituted by a lower alkanoyloxy group, (18) an aryl group substituted by a hydroxyl group, and (19) a hydroxy-lower alkanoyl group, (ii) a group of a formula: optionally substituted by an oxo group, and (iii) a lower alkyl group optionally substituted by an amino group optionally substituted by a group selected from (a) a lower alkyl group, (b) a lower alkoxycarbonyl group, and (c) a lower alkanoyl group; or A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R 1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring B of the formula: is a benzene ring optionally substituted by a group(s) selected independently from (i) a halogen atom, (ii) a lower alkyl group optionally substituted by a group selected from the following: (1) a lower alkoxycarbonyl group, (2) a carboxyl group, (3) a carbamoyl group optionally substituted by a group selected from (a) a lower alkyl group, (b) a lower alkoxylower alkyl group, (c) a lower alkyl group substituted by a hydroxyl group, and (d) a lower alkoxy group, (4) a carbonyl group substituted by a morpholinyl group, (5) a hydroxyl group; (iii) a hydroxy group, (iv) a lower alkoxy group optionally substituted by a group selected from the following: (1) a carboxyl group, (2) a lower alkoxycarbonyl group, (3) a lower alkoxy group, (4) a hydroxyl group, (5) an aminooxy group optionally substituted by a lower alkoxycarbonyl group, (6) a lower alkoxy group substituted by a lower alkoxy group, (7) an amino group optionally substituted by (a) a lower alkyl group, (b) a lower alkoxycarbonyl group, and (c) a lower alkanoyl group, (8) a carbamoyl group optionally substituted by a group selected from (a) a lower alkyl group, (b) a lower alkoxy-lower alkyl group, (c) a lower alkyl group substituted by a hydroxyl group, and (d) a lower alkyl group substituted by a di-lower alkylamino group; and (9) a group of the formula: —O—NH—C(═NH)NH (v) a carbonyl group substituted by a group selected from the following: (1) a lower alkoxy group, (2) a hydroxyl group, (3) an amino group optionally substituted by (a) a lower alkyl group, (b) a lower alkoxy group, (c) a lower alkoxy-lower alkyl group, (d) a hydroxy-lower alkyl group, (e) a lower alkyl group substituted by an amino group optionally substituted by a lower alkyl group, (f) a lower alkyl group substituted by an aryl group, and (4) a morpholinyl group, (vi) an amino group optionally substituted by a group selected from the following: (1) a lower alkyl group, (2) a lower alkoxy-lower alkyl group, (3) a hydroxy-lower alkyl group, (4) a lower alkanoyl group, (5) a lower alkoxy-lower alkanoyl group, (6) a hydroxy-lower alkanoyl group, (7) a lower alkanoyl group substituted by a lower alkanoyloxy group, (8) a lower alkanoyl group substituted by an amino group optionally substituted by a group selected from (a) a lower alkyl group and (b) a lower alkanoyl group, (9) a lower alkoxycarbonyl group, (10) a lower alkoxycarbonyl group substituted by an aryl group, (11) a carbamoyl group substituted by a lower alkyl group, and (12) a lower alkylsulfonyl group, (vii) a nitro group, (viii) a cyano group, and (x) a group of the formula: R 3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof.