Patent ID: 7776319
Filing Date: 2010-08-17
Classification: A61K,A61P,C08F,Y10S

Abstract:
1. A method of removing sodium from an animal subject comprising administering to an animal subject in need thereof an effective amount of a core-shell composition comprising a cation exchange core and a semi-permeable shell wherein the semi-permeable shell comprises a polymer containing hydrophobic monomers and basic monomers that ionize at low pH and remain neutral beyond their pKa, said hydrophobic monomers selected from the group consisting of a long chain alcohol (meth)acrylate, an N-alkyl (meth)acrylate and an aromatic monomer, and said basic monomers selected from the group consisting of vinyl pyridine and dialkylaminoethyl (meth)acrylamide, wherein the core-shell composition has a high permeability to sodium at low pH and a low permeability to sodium at about neutral pH whereby as the core-shell composition passes through to the lower GI tract, its permeability to sodium decreases.