Patent ID: 7902153
Filing Date: 2011-03-08
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An isolated α-conotoxin peptide having the generic formula III: Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Cys-Cys-Xaa 6 -Xaa 7 -Xaa 8 -Xaa 9 -Cys-Xaa 10 -Xaa 11 -Xaa 12 -Xaa 13 -Xaa 14 -Xaa 15 -Xaa 16 -Cys-Xaa 17 -Xaa 18 -Xaa 19 -Xaa 20 -Xaa 21 -Xaa 22 -Xaa 23 -Xaa 24 (SEQ ID NO:3), wherein Xaa 1 is des-Xaa 1 , Xaa 2 is des-Xaa 2 , Xaa 3 is des-Xaa 3 , Xaa 4 is Asp, Xaa 5 is Glu or Gla, Xaa 6 is Ser, Xaa 7 is Asn, Xaa 8 is Pro or hydroxy-Pro, Xaa 9 is Ala, Xaa 10 is Arg, Xaa 11 is Leu, Xaa 12 is Asn, Xaa 13 is Asn, Xaa 14 is Pro or hydroxy-Pro, Xaa 15 is His, Xaa 16 is Ala or Val, Xaa 17 is Arg, Xaa 18 is Arg, Xaa 19 is Arg, Xaa 20 is des-Xaa 20 , Xaa 21 is des-Xaa 21 , Xaa 22 is des-Xaa 22 , Xaa 23 is des-Xaa 23 and Xaa 24 is des-Xaa 24 ; wherein the C-terminus contains a hydroxyl group or an amide group; wherein the His residue may be substituted with a halo-His residue; wherein an Arg residue may be substituted with homoarginine; and wherein the Cys residues may be in the D or L configuration or substituted with homocysteine in the D or L configuration.