Patent ID: 8962607
Filing Date: 2015-02-24
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) selected from the group consisting of: a compound wherein Y is furan-2-yl, Z is 4-cyclohexylphenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-bromonaphth-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-trifluoromethylbenzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethylbenzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-bromo-3-chloro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-trifluoromethylbenzothien-3-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 7-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-bromo-3-chloro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethylbenzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(cyclohexylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(cyclobutylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-fluorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(phenylmethyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenylmethyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-phenyl-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(pyrimidin-2-yl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-chlorophenoxyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenoxyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3,4-dichlorophenoxyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenoxyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenylthio)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenylthio)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methoxy-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-7-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenyl-sulfonyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is phenoxathiin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-n-propyl-phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(N,N-(dipropyl)aminosulfonyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-5-trifluoromethyl-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-(3-trifluoromethylphenoxyl)pyridin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-4-(3-chlorophenoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-trifluoromethyl-6-chloro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(thien-2-ylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-5-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(pyrimidin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-pyrrolidin-1-yl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-7-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4,4-difluoropiperidin-1-yl)-benzothiazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-t-butyl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-5-chloro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl), and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0; a compound wherein Y is pyrrol-2-yl, Z is phenoxathiin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 7-bromo-1-methyl-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethyl-cyclohexylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is isothiazol-5-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(phenylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-5-methyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenylsulfonyl)-phenyl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl), and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-isopropyl-2-trifluoromethyl-benzimidazol-5-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is 1H-pyrrol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6,7-dichloro-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(2,3-dimethyl-phenylamino)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-bromo-5-methyl-thien-2-yl, and s is 0; a compound wherein Y is 3-bromo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-1H-indol-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is 1H-pyrrol-3-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-trifluoromethyl-thieno[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 9-methyl-9H-carbazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-fluoro-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-(pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is 1,2,3-thiadiazol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-fluoro-phenylamino)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-5-chloro-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(5-chloro-pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1,3-dimethyl-5-chloro-indol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-7-methoxy-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2,2,2-trifluoroethyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is 1,3-dimethyl-5-chloro-indol-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6,7,8,9-tetrahydro-5H-carbazol-3-yl, and s is 0; a compound wherein Y is 5-chloro-benzothiazol-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(5-bromo-pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2,2-dimethyl-2,3-dihydro-benzofuran-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 9-methyl-9H-carbazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethyl-phenylamino)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-1H-indol-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(cyclopropylcarbonyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethylamino)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3,5-di-t-butyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is 4-chloro-2-trifluoromethyl-quinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(phenylamino)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(2-methoxy-ethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-benzothiazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(6-fluoro-pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is 5-chloro-benzofuran-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-bromo-2-methyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 7-chloro-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2,6-dimethyl-1-(2,2,2-trifluoro-ethyl)-pyrrol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(3-trifluoromethyl-phenylthio)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-chloro-2-methyl-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-bromo-1H-indol-2-yl, and s is 0; a compound wherein Y is 1-cyclohexyl-2-methyl-1H-benzimidazol-5-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 7-fluoro-3-methyl-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethylamino)-thiazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1,2-dimethyl-1H-indol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-chloro-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-cyclohexyl-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R a compound wherein Y is trifluoromethyl, Z is 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-(3-chloro-phenoxy)-pyridin-3-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-2-yl, and s is 1, and R a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-bromo-thien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 10-oxidophenoxathiin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-furo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is 5-chloro-benzofuran-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is pyridin-2-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-(2-chloro-phenoxy)-pyridin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-bromo-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(2,2-difluoro-ethyl)-1H-indol-5-yl, and s is 0; a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is 4-trifluoromethyl-thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(morpholin-4-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(ethylaminocarbonyl-methoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6,7,8,9-tetrahydro-5H-carbazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-chloro-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(pyrimidin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1H-indazol-5-yl, and s is 0; a compound wherein Y is 5-chloro-benzothiazol-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(phenylsulfonyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5,7-dichloro-2-methyl-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6,7-dihydro-5H-1-thia-4a,8-diaza-s-indacen-4-one-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-bromo-3-methyl-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 7-chloro-2-methyl-quinolin-3-yl, and s is 0; a compound wherein Y is 2-cyclohexyl-1H-benzimidazol-5-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is 5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(isopropyl)-2-trifluoromethyl-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(cyclohexyl)-2-methyl-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R a compound wherein Y is thiazol-4-yl, Z is 1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-chloro-2-methyl-quinolin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(2-methylcarbonylamino-ethoxy)-phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-indol-3-yl, and s is 0; a compound wherein Y is 1,3-dimethyl-5-chloro-indol-2-yl, Z is 1H-pyrrol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-7-methoxy-1H-indol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(2,2,2-trifluoroethyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is 4-chloro-2-trifluoromethyl-quinolin-6-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-furo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-7-methoxy-quinolin-3-yl, and s is 0; a compound wherein Y is 3-methyl-7-methoxy-1H-indol-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-hydroxyphenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-chloro-2-trifluoromethyl-quinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methoxy-5-t-butyl-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-methoxy-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-bromo-7-methyl-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is 2-cyclohexyl-1H-benzimidazol-5-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is 3-methyl-2-phenyl-4-oxo-chromen-8-yl, Z is thiazol-2-yl, s is 1, and R a compound wherein Y is thiazol-4-yl, Z is 5-chloro-benzothiazol-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1H-indol-5-yl, and s is 0; a compound wherein Y is 3-methyl-7-methoxy-1H-indol-2-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(2,2,2-trifluoroethyl)-2-methyl-benzimidazol-5-yl, and s is 0; a compound wherein Y is 4-chloro-2-trifluoromethyl-quinolin-6-yl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is 6-trifluoromethyl-furo[2,3-b]pyridin-2-yl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-t-butoxycarbonyl-3,4-dihydro-1H-isoquinolin8-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-fluoro-3-methyl-benzofuran-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-bromo-furo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-(3,3,3-trifluoro-propyl)-2-methyl-1H-benzimidazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-bromo-3-methyl-imidazo[1,2-a]pyridin-2-yl), and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(pyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 7-fluoro-3-methyl-benzofuran-2-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(5-bromopyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-bromo-imidazo[1,2-a]pyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-phenylcarbonyl-1H-pyrrol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenoxy)-3-fluoro-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylsulfonyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(5-bromopyridin-2-yloxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-(2-fluoro-5-trifluoromethylphenoxy)-pyridin-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylphenyl-methyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenyl-methyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenyl-methyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl-methyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-4-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is phenoxathiin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(1,1-dimethylpropyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-azepan-1-yl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-cyclohexyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-chloro-naphtho[2,1-b]thiophen-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-isobutyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-heptyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-pentyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-n-butyl-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-chloro-3-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-methyl-5-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-5-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-5-trifluoromethyl-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-fluoro-7-trifluoromethyl-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(1-t-butoxycarbonyl-piperidin-4-yl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(5-methoxypyridin-3-yloxy)-phenyl, and s is 0; a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4,4-difluorocyclohexylcarbonyl)-1H-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 9,9-dimethyl-9H-fluoren-2-yl, and s is 0; or a pharmaceutically acceptable salt form thereof.