Patent ID: 6538010
Filing Date: 2003-03-25
Classification: A61K,A61P,C07D

Abstract:
A compound represented by formula (II): whereinA3 is â€”R, â€”N(R)2, â€”C(&boxH;NR)N(R)2, or â€”OR; each Q is, independently, Câ€”X or N, with the proviso that at least one Q is N and at least one Q is Câ€”X; each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, â€”OH, â€”OR, â€”CH2â€”CO2R, â€”COâ€”R, â€”CO2R, â€”N(R)2, â€”NRâ€”COâ€”R, â€”COâ€”N(R)2, â€”NRCO2R, â€”SO3CF3, â€”NO2, â€”N3, â€”CF3, â€”CH&boxH;CHY, or â€”CN, with the proviso that at least one X is represented by the formula: â€ƒwherein each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, â€”OH, â€”OR, â€”CH2â€”CO2R, â€”COâ€”R, â€”CO2R, â€”N(R)2, â€”NRâ€”COâ€”R, â€”COâ€”N(R)2, â€”NRCO2R, â€”SO3CF3, â€”NO2, â€”N3, â€”CF3, â€”CH&boxH;CHY, or â€”CN, or two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group; and c is 1, 2, 3, 4 or 5; Y is a halogen; and each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl; or a pharmaceutically acceptable salt thereof.