Patent ID: 6720335
Filing Date: 2004-04-13
Classification: A61K,C07C,C07D,C07K

Abstract:
A compound of formula I: wherein:A is selected from the group consisting of Het; â€”R1-Het; each R1 is independently selected from the group consisting of â€”C(O)â€”, â€”S(O)2â€”, â€”C(O)â€”C(O)â€”, â€”Oâ€”C(O)â€”, â€”Oâ€”S(O)2, â€”NR2â€”S(O)2â€”, â€”NR2â€”C(O)â€” and â€”NR2â€”C(O)â€”C(O)â€”; each Het is independently selected from the group consisting 5-7 membered saturated or unsaturated heterocycle, containing one or more heteroatoms selected from N and N(R2), wherein said heterocycle may optionally be benzofused; and wherein said Het may be optionally substituted with one or more substituents selected from the group consisting of oxo, â€”OR2, â€”R2, â€”N(R2) (R2), â€”R2â€”OH, â€”CN, â€”CO2R2, â€”C(O)â€”N(R2) (R2), â€”S(O)2â€”N(R2) (R2), â€”N(R2)â€”C(O)â€”R2, â€”C(O)â€”R2, â€”S(O)nâ€”R2, â€”OCF3, â€”S(O)nâ€”Ar, methylenedioxy, â€”N(R2)â€”S(O)2(R2), halo, â€”CF3, â€”NO2, Ar and â€”Oâ€”Ar; each R2 is independently selected from the group consisting of H and C1-C3 alkyl optionally substituted with Ar; with the proviso that when R2 is C1-C3 alkyl substituted with Ar, said Ar may not be substituted with an Ar-containing moiety; B, when present, is â€”N(R2)â€”C(R3) (R3)â€”C(O)â€”; x is 0 or 1; each R3 is independently selected from the group consisting of H, Het, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl and C5-C6 cycloalkenyl, wherein any member of said R3, except H, may be optionally substituted with one or more substituents selected from the group consisting of â€”OR2, â€”C(O)â€”NHâ€”R2, â€”S(O)nâ€”N(R2) (R2), Het, â€”CN, â€”SR2, â€”COR2, NR2â€”C(O)â€”R2; each n is independently 1 or 2; D and Dâ€² are independently selected from the group consisting of Ar; C1-C4 alkyl, which may be optionally substituted with one or more groups selected from C3-C6 cycloalkyl, â€”OR2, â€”R3, â€”Oâ€”Ar and Ar; C2-C4 alkenyl, which may be optionally substituted with one or more groups selected from the group consisting of C3-C6 cycloalkyl, â€”OR2, â€”R3, â€”Oâ€”Ar and Ar; C3-C6 cycloalkyl, which may be optionally substituted with or fused with Ar; and C5-C6 cycloalkenyl, which may be optionally substituted with or fused with Ar; each Ar is independently selected from the group consisting of phenyl; 3-6 membered carbocyclic ring, wherein said carbocyclic ring may be saturated or unsaturated and optionally substituted with one or more groups selected from the group consisting of oxo, â€”OR2, â€”R2, â€”N(R2) (R2), â€”N(R2)â€”C(O)â€”R2, C1-C3 alkyl substituted with â€”OH and optionally substituted with R7, â€”CN, â€”CO2R2, â€”C(O)â€”N(R2) (R2), halo and â€”CF3; E is selected from the group consisting of HetE; O-HetE; HetE-HetE; each HetE is independently selected from the group consisting 5-7 membered saturated or unsaturated heterocycle, containing one or more heteroatoms selected from N, N(R2) and O, wherein said heterocycle may optionally be benzofused; and wherein any member of said HetE may be optionally substituted with one or more substituents selected from the group consisting of oxo, â€”OR2, â€”R2, â€”N(R2) (R2), â€”R2â€”OH, â€”CN, â€”CO2R2, â€”C(O)â€”N(R2) (R2), â€”S(O)2â€”N(R2) (R2), â€”N(R2)â€”C(O)â€”R2, â€”C(O)â€”R2, â€”S(O)nâ€”R2, â€”OCF3, â€”S(O)nâ€”Ar, methylenedioxy, â€”N(R2)â€”S(O)2(R2), halo, â€”CF3, â€”NO2, Ar and â€”Oâ€”Ar; and each R4 is independently selected from the group consisting of â€”OR2, â€”C(O)â€”NHR2, â€”S(O)2â€”NHR2, halo, â€”NR2â€”C(O)â€”R2 and â€”CN.