Patent ID: 6291432
Filing Date: 2001-09-18
Classification: C07D,C07K

Abstract:
A compound having the following formula (I), ##STR28##whereinA is --NH--, --NR-- (wherein R represents an alkyl group having 1 to 6 carbon atoms), --O--CH.sub.2 --, --CH.sub.2 --O-- or a single bond;B is --CO-- or --SO.sub.2 --;D is --CO-- or --CH.sub.2 --;E representsi) a divalent hydrocarbon chain --(CH.sub.2).sub.n -- wherein n is an integer ranging from 3 to 5, wherein E forms a 5 to 7 member ring together with the adjacent nitrogen atom and carbon atom, and wherein one or more carbon atom positions of E are replaced by one or more nitrogen, oxygen or sulfur atoms, orii) a divalent hydrocarbon chain as described in i) above further comprising 2 or more substituents, said substituents being selected from the group consisting ofa linear and branched aliphatic hydrocarbon group having 1 to 6 carbon atoms, aromatic hydrocarbon group, heteroaromatic group, hydroxyl group, linear and branched aliphatic hydrocarbonoxy group having 1 to 6 carbon atoms and halogeno group,wherein said substituents optionally form a another condensed 5 to 7 member ring;R.sup.1 is i) a hydrogen atom,ii) an alkyl group having 1 to 6 carbon atoms, wherein the said alkyl group is optionally substituted by an alkyloxy group having 1 to 4 carbon atoms, oriii) an aromatic group, a heterocyclic group, said aromatic and said heterocyclic groups having 1 to 10 carbon atoms and being optionally substituted byan alkyl group having 1 to 4 carbon atoms,an hetero alkyl group selected fromalkyloxy group, mono or dialkyl-substituted amino group, wherein the alkyl group has 1-4 carbon atoms,halogeno group, hydroxyl group, amino group, oran alkyl or alkenyl group having 3 or less carbon atoms which may be substituted by a monocyclic aromatic group or monocyclic heteroaromatic group;R.sup.2 is i) a linear or branched aliphatic hydrocarbon group having 1-7 carbon atoms,ii) an aromatic hydrocarbon group,iii) said aliphatic hydrocarbon group or aromatic hydrocarbon group of i) and ii) further comprising a hetero atom in place of a carbon atom, oriv) said aliphatic hydrocarbon group or aromatic hydrocarbon group of i) to iii)wherein a hydrogen atom is substituted by a carbamoyl group, carboxyl group, or halogeno group;R.sup.3 is an aryl group, arylthio group or aryloxy group, and wherein the aryl moiety is optionally substituted by 1 to 2 of the substituents selected from the group consisting ofan alkyl, alkyloxy group, and alkylamino group, wherein the alkyl moiety is an alkyl group of 1 to 4 carbon atoms,a halogeno group, hydroxyl group, and amino group; andR.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 respectively represent a hydrogen atom, alkyl group having 1 to 3 carbon atoms, halogeno group, amino group, hydroxyl group, aminomethyl group, hydroxymethyl group, or an amino group substituted by one or two alkyl groups having 1 to 3 carbon atoms; ora pharmaceutically acceptable salt thereof.