Patent ID: 8212052
Filing Date: 2012-07-03
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein: r is 0, 1 or 2; Ar is: R R 1a is H, —C 1-6 alkyl, —C 1-3 alkylenearyl, —C 1-3 alkyleneheteroaryl, —C 3-7 cycloalkyl, —CH(C 1-4 -alkyl)OC(O)R 1aa , —C 0-6 alkylenemorpholine, R 1aa is —C 1-6 alkyl, —O—C 3-7 cycloalkyl, —NR 1ab R 1ac , or —CH(NH 2 )CH 2 COOCH 3 ; R 1ab and R 1ac are independently H, —C 1-6 alkyl, or benzyl, or are taken together as —(CH 2 ) 3-6 —; R 1b is R 1c or —NHC(O)R 1c ; R 1c is —C 1-6 alkyl, —C 0-6 alkylene-O—R 1ca , —C 1-5 alkylene-NR 1cb R 1cc , —C 0-4 alkylenearyl, or —C 0-4 alkyleneheteroaryl; R 1ca is H, —C 1-6 alkyl, or —C 1-6 alkylene-O—C 1-6 alkyl; R 1cb and R 1cc are independently H or —C 1-6 alkyl, or are taken together as —(CH 2 ) 2 —O—(CH 2 ) 2 — or —(CH 2 ) 2 —N[C(O)CH 3 ]-(CH 2 ) 2 —; R 1d is H, R 1c , —C(O)R 1c , or —C(O)NHR 1c ; R 1e is —C 1-4 alkyl or aryl; n is 0, 1, or 2; each R R R X is —C(O)—NH—; R R R wherein each —CH each alkyl and each aryl in R each ring in Ar and each aryl and heteroaryl in R or a pharmaceutically acceptable salt thereof.