Patent ID: 7124068
Filing Date: 2006-10-17
Classification: C12N

Abstract:
1. A method for identifying a potential deacetylase inhibitor compound for an enzyme which comprises deacetylase activity, wherein said enzyme is selected from the group consisting of histone deacetylase-like protein (HDLP) and histone deacetylase 1 (HDAC 1), said method comprising the steps of: a) using a three-dimensional structure of HDLP as defined by atomic coordinates according to FIG. 16 ; b) employing said three-dimensional structure to design or select said potential inhibitor such that said potential inhibitor is capable of binding to at least one amino acid in the active site of HDLP; c) synthesizing said potential inhibitor; d) in an assay, contacting said potential inhibitor with said enzyme in the presence of an acetylated substrate; and e) determining the deacetylase inhibitory activity of said potential inhibitor.