Patent ID: 8653277
Filing Date: 2014-02-18
Classification: A01N,C07D

Abstract:
1. A process for producing 3-(2,3,4-trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridine or a salt thereof, comprising: (a) reacting 5-chloro-2-methoxy-4-methylnicotinic acid with a halogenating agent to obtain a 5-chloro-2-methoxy-4-methylnicotinic acid halide, and (b) subjecting the 5-chloro-2-methoxy-4-methylnicotinic acid halide obtained in (a), without isolating the acid halide, and 3,4,5-trimethoxytoluene to a Friedel-Crafts reaction in a solvent selected from the group consisting of 1,2-dichloroethane, methylene chloride, chlorobenzene, dichlorobenzene, and mixtures thereof to obtain the 3-(2,3,4-trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridine.