Patent ID: 7820678
Filing Date: 2010-10-26
Classification: A61K,A61P,C07D

Abstract:
1. A method of increasing hydration of a mucosal surface of a subject, comprising topically administering to a mucosal surface of a subject an effective amount of a compound represented by formula (I): where X is hydrogen, halogen, trifluoromethyl, lower alkyl, unsubstituted or substituted phenyl, lower alkyl-thio, phenyl-lower alkyl-thio, lower alkyl-sulfonyl, or phenyl-lower alkyl-sulfonyl; Y is hydrogen, hydroxyl, mercapto, lower alkoxy, lower alkyl-thio, halogen, lower alkyl, unsubstituted or substituted mononuclear aryl, or —N(R R each R wherein when two —CH R wherein wherein when two R wherein when two —CH Q in the ring are nitrogen atoms; or a pharmaceutically acceptable salt thereof, and inclusive of all enantiomers, diastereomers, and racemic mixtures thereof.