Patent ID: 7271183
Filing Date: 2007-09-18
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I wherein: m is from 1 to 4; n is from 0 to 4; A is: cyclopropylethyl; 4′-chloro-2′-methyl-biphenyl; 4-hydroxy-3-methyl-benzyl; 3-(methoxy-methyl)-phenyl; 4-hydroxy-3-isopropyl-phenyl; 1-phenyl-cyclopropyl; 4-hydroxy-2′-methyl-biphenyl; cyclobutylethyl; 3-(3-fluorophenoxy)-phenyl; 2,5-dimethylphenyl; phenoxyymethyl; 3′-chloro-biphenyl; or 3-trifluoromethyl-benzyl; E is —CHOH—; X is —(CH 2 ) 2 — or —CH═CH—; Y is —CH 2 —, —CH═CH—, —O—, —S(O) p — where p is from 0 to 2, or —NR a — where R a is hydrogen or alkyl; Z is —COOR b where R b is hydrogen or alkyl; and R 1 ,R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 each independently are hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.