Patent ID: 6271227
Filing Date: 2001-08-07
Classification: A61P,C07D

Abstract:
A compound of formula I (or a pharmaceutically acceptable salt thereof) ##STR71##whereinA is carbonyl or methylene;D is CH, CR.sup.d or N in which R.sup.d is methyl or methoxy;E is CH, CR.sup.e or N in which R.sup.e is methyl, methoxy or halo;R.sup.2 and R.sup.3 are defined together such thatA. R.sup.2 is --X.sup.2 --(CH.sub.2).sub.m --NR.sup.a R.sup.b in which X.sup.2 is a direct bond, methylene or O; m is 1, 2, 3, 4 or 5; provided that when m is 1, then X.sup.2 is a direct bond; and R.sup.a and R.sup.b are independently hydrogen or (1-3C)alkyl or the group NR.sup.a R.sup.b is pyrrolidino, piperidino, or morpholino; andR.sup.3 is --CH.sub.2 --R.sup.c, in which R.sup.c is 2-carboxypyrrolidin-1-yl or 2-[[(1-4C)alkoxy]carbonyl]pyrrolidin-1-yl; orB. R.sup.2 is --X.sup.2 --(CH.sub.2).sub.n --R.sup.f in which X.sup.2 is a direct bond, methylene or O; n is 1, 2 or 3; provided that when n is 1, then X.sup.2 is a direct bond; and R.sup.f is 2-carboxypyrrolidin-1-yl, 2-[[(1-4C)alkoxy]carbonyl]pyrrolidin-1-yl, (carboxymethyl)amino, [[(1-4C)alkoxy]carbonylmethyl]amino, (4-carboxymethylimidazol-1-yl)amino, [4-[[(1-4C)alkoxy]-carbonylmethyl]imidazol-1-yl]amino, (4-carboxybenzyl)amino, [4-[[(1-4C)alkoxy]carbonyl]benzyl]amino, (3-amino-1,4-dioxo-4-hydroxybutyl)amino or [3-amino-1,4-dioxo-4-[(1-4C)alkoxy]-butyl]amino; or R.sup.2 is --X.sup.2 --(CH.sub.2).sub.n --R.sup.f in which X.sup.2 is a direct bond; n is 0; and R.sup.f is (3-amino-1,4-dioxo-4-hydroxybutyl)-amino, [3-amino-1,4-dioxo-4-[(1-4C)alkoxy]butyl]amino, (4-amino-l,5-dioxo-5-hydroxypentyl)amino or [4-amino-1,5-dioxo-5-[(1-4C)alkoxy]butyl]amino;R.sup.3 is is --X.sup.3 --(CH.sub.2).sub.s --NR.sup.g R.sup.h in which X.sup.3 is a direct bond, methylene or O; s is 1 or 2; provided that when s is 1, then X.sup.3 is a direct bond; and R.sup.s and R.sup.t are independently hydrogen or (1-3C)alkyl or the group NR.sup.s R.sup.t is pyrrolidino, piperidino, or morpholino; andR.sup.6 is hydrogen, hydroxy or methoxy.