Patent ID: 8142795
Filing Date: 2012-03-27
Classification: A61K,A61P,C12N

Abstract:
1. A stabilizer for compositions comprising one or more live attenuated flaviviruses, which comprises, in an aqueous solution without proteins of animal origin and without added salts having divalent cations, a buffer, 2.5% to 6.5% of sorbitol, 2.5% to 13% of sucrose, 0 to 7.5% of trehalose and/or 0 to 7.5% of a disaccharide other than sucrose or trehalose or a trisaccharide, 0.2% to 0.5% of urea, 0.8% to 2.5% of an amino acid mixture comprising arginine (Arg), cystine (Cys-Cys), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), methionine (Met), phenylalanine (Phe), threonine (Thr), tryptophan (Trp), tyrosine (Tyr), valine (Val), alanine (Ala), asparagine (Asn), aspartic acid (Asp), glutamic acid (Glu), glycine (Gly), proline (Pro) and serine (Ser).