Patent ID: 7470510
Filing Date: 2008-12-30
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method for determining whether a human subject harbors a mutation in an hMYH gene of the human subject that decreases an activity of the encoded hMYH protein, said method comprising: providing an hMYH-encoding nucleotide sequence of the human subject; and determining the presence or absence of a difference in a coding region in said hMYH-encoding nucleotide sequence, relative to SEQ ID NO:1, which results in decreased binding of the encoded hMYH protein to a substrate containing an A/GO mispair, or decreased glycosylase activity of the encoded hMYH protein on the mispaired adenosine in an A/GO mispair in a substrate containing an A/GO mispair.