Patent ID: 6506751
Filing Date: 2003-01-14
Classification: A61P,C07D

Abstract:
A compound of the formula and pharmaceutically acceptable salts, esters, and amides thereof, wherein:A is S; R1 and R2 are independently hydrogen, halogen, hydroxy or lower alkoxy; arylalkyl or heteroarylalkyl where each ring is optionally substituted independently with up to three groups selected from halogen, lower alkyl, lower alkoxy, hydroxy, carboxy, alkoxycarbonyl, cyano, nitro, trifluoromethyl, amino, mono- or dialkylamino, carbamoyl, carboxyalkyl, alkoxycarbonylalkyl, or sulfamoyl; or aryl or heteroaryl where each ring is substituted independently with up to three groups selected from halogen, hydroxy, carboxy, alkoxycarbonyl, cyano, trifluoromethyl, amino, mono- or dialkylamino, carbamoyl, carboxyalkyl, alkoxycarbonylalkyl, or sulfamoyl; R3 represents hydrogen, lower alkyl, cycloalkyl, aminoalkyl or mono- or dialkylaminoalkyl; or aryl or heteroaryl optionally substituted with up to three groups selected from halogen, lower alkyl, lower alkoxy, hydroxy, carboxy, alkoxycarbonyl, cyano, nitro, trifluoromethyl, amino, mono- or dialkylamino, carbamoyl, carboxyalkyl, alkoxycarbonylalkyl, sulfamoyl or sulfamoyl; R4 represents hydrogen, lower alkyl, cycloalkyl, aminoalkyl or mono- or dialkylaminoalkyl; R5 represents a carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen, where the carbocyclic group is optionally substituted with one or two groups selected from halogen, lower alkyl, lower alkoxy, mono- or dialkylamino, aryl, arylalkyl or a heterocyclic group; or R5 is (CR6R7)â€”(CH2)nâ€”XR8R9; X is N; R6 and R7 independently represent hydrogen, lower alkyl, hydroxy, amino, or mono- or dialkylamino; n is 0, 1, 2, 3 or4; and R8 and R9 independently represent hydrogen, lower alkyl, lower alkenyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl or cycloalkyl; or R8 and R9 together with the nitrogen to which they are attached form a heterocyclic ring containing from 5-7 members, up to two of which members are optionally hetero atoms selected from oxygen, sulfur and nitrogen, where the heterocyclic ring is optionally substituted with one or two groups selected from halogen, lower alkyl, lower alkoxy, mono- or dialkylamino, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkyl or a heterocyclic group.