Patent ID: 6451834
Filing Date: 2002-09-17
Classification: A61K,A61P,C07D

Abstract:
A method of inhibiting tyrosine kinase activity comprising administering to a patient in need thereof of a compound represent by the formula: where ring A represents the tautomeric structures n is 1, 2, or 3; Ar is andR1, R2, R4 and R5 each independently represent hydrogen, halogen having an atomic weight of about 19 to 36, lower alkyl having 1 to 4 carbon atoms, lower alkoxy, trifluoromethyl or R1, R2 and R4, R5 together independently represent methylenedioxy attached to adjacent carbon atoms; R3 is hydrogen â€”COR6, or â€”SO2R6; and R6 is â€”CH3 or wherein Y is hydrogen, chlorine or â€”CH3 in sufficient concentration to inhibit the enzyme activity of said tyrosine kinase.