Patent ID: 6207716
Filing Date: 2001-03-27
Classification: A61K,A61P,C07B,C07C,C07D,C07F

Abstract:
A compound of Formula I: ##STR12##whereinR.sup.1 is --(CH.sub.2).sub.n CR5.dbd.CR.sup.6 R.sup.7 ; --(CH.sub.2).sub.m C(X)NR.sup.8 R.sup.9 ; or ##STR13##R.sup.2 and R.sup.3 are independently H, --CH.sub.3, --OH, --OCH.sub.3, --OCH.sub.2 CH.sub.3 or --CH.sub.2 (CH.sub.3).sub.2 ;R.sup.4 is --CN, --NO.sub.2, --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 --Y or --Y;R.sup.5 and R.sup.6 are independently H, --C.sub.1-4 alkyl, --C.sub.2-4 alkenyl, --C.sub.2-4 alkynyl, --X--C.sub.1-3 alkyl, --X--C.sub.2-4 alkenyl, --X--C.sub.2-4 alkynyl or --Y;R.sup.7 is --CN, --C.sub.1-4 alkyl--OH, --C(O)O(CH.sub.3).sub.3, --C(O)NR.sup.10 R.sup.11, --C(O)NR.sup.12 R.sup.13, --C.sub.1-4 alkyl--NR.sup.10 R.sup.11, --C(O)R.sup.12, --C(O)OR.sup.12, --C(O)NR.sup.12 OR.sup.13, --C(O)NHC(O)R.sup.12, --C(O)NHCH.sub.2 R.sup.12, --C(NH.sub.2)(NOR.sup.12), --S(O)R.sup.12, --S(O)(O)(OR.sup.12), --S(O)(O)(NHCO.sub.2 R.sup.12), PO.sub.3 R.sup.12, --P(O)(NR.sup.12 R.sup.13)(NR.sup.12 R.sup.13), --P(O)(NR.sup.12 R.sup.13)(OR.sup.14), --CONR.sup.12 (CH.sub.2).sub.q OCH.sub.3, --CONR.sup.12 (CH.sub.2).sub.q NR.sup.8 R.sup.9 or oxadizole substituted with methyl;R.sup.8 and R.sup.9 are independently hydrogen, --C.sub.1-7 alkyl, --C.sub.3-7 cycloalkyl, --O--C.sub.1-7 alkyl, --C.sub.1-7 alkyl--Y or phenyl;R.sup.10 and R.sup.11 are independently methyl or ethyl or, taken together form a morpholino group bonded via its nitrogen atom;R.sup.12, R.sup.13 and R.sup.14 are independently H, --C.sub.1-12 alkyl, --C.sub.2-12 alkenyl, --C.sub.2-12 alkynyl, --O--C.sub.1-12 alkyl, --O--C.sub.2-12 alkenyl, --O--C.sub.2-12 alkynyl, --C.sub.3-7 cycloalkyl, --C.sub.3-7 cycloalkenyl, linear and cyclic heteroalkyl, aryl, heteroaryl or --Y;X is oxygen or sulfur;Y is a halogen;n is an integer selected from 0, 1 or 2;m is the integer 1 or 2;p is an integer selected from 1 to 4; andq is an integer from 1-12.