Patent ID: 6156754
Filing Date: 2000-12-05
Classification: A61K,A61P,C07K

Abstract:
Compounds of the formula (I) ##STR29## in which n, m and o in each case represent the number 0 or 1 and n+m+o is .gtoreq.1 whereCp represents a camptothecin radical of the formulae ##STR30## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another may represent hydrogen, alkyl having up to 3 carbon atoms, halogen, amino, hydroxyl or nitro orR.sup.2 and R.sup.3 together represent a group of the formula ##STR31## p may have the values 1 or 2 and R.sup.5 represents --O--*, --NH* or ##STR32## or represents --*NR.sup.6, in which R.sup.6 represents arylmethyl or hetarylmethyl, ##STR33## in which R.sup.7 and R.sup.8 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these, ##STR34## in which R.sup.9 represents hydrogen or --CH.sub.2 --N(CH.sub.3).sub.2 andR.sup.10 represents hydrogen or ethyl, ##STR35## in which R.sup.11 and R.sup.12 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these, or ##STR36## in which R.sup.13 and R.sup.14 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these,where Cp is attached to M via the bonds labelled *,M represents a bridge grouping whose main chain includes up to 21 atoms in linear order,L.sup.1, L.sup.2 and L.sup.3 independently of one another each represent linker groupings,Sp.sup.1, Sp.sup.2 and Sp.sup.3 independently of one another each represent arylene having up to 10 carbon atoms or represent alkylene having up to 8 carbon atoms which are in each case optionally substituted, andK.sup.1, K.sup.2 and K.sup.3 independently of one another each represent a radical of the formula (II) ##STR37## in which A represents methyl, hydroxymethyl, alkoxymethyl having up to 6 carbon atoms, acyloxymethyl having up to 6 carbon atoms or a radical of the formula --CH.sub.2 --B in whichB represents a radical of the formula (II),R.sup.15, R.sup.16 and R.sup.17 independently of one another each represent hydrogen, hydroxyl, optionally hydroxyl-substituted alkoxy having up to 6 carbon atoms, amino which is optionally substituted by alkyl or acyl having up to 6 carbon atoms, halogen, sulphate or a group of the formula ##STR38## in which R.sup.18 and R.sup.19 independently of one another each represent hydroxyl or alkoxy having up to 6 carbon atoms or represent amino which is optionally substituted by alkyl having up to 6 carbon atoms, ands and t independently of one another may each have the values 0, 1, 2, 3 or 4, orR.sup.15, R.sup.16 and R.sup.17 independently of one another each represent a radical of the formula (II) ortwo of the radicals R.sup.15, R.sup.16, R.sup.17 together represent an epoxy group,and their isomers, isomer mixtures and salts.