Patent ID: 6482821
Filing Date: 2002-11-19
Classification: C07D

Abstract:
A compound of the formula I,A-B-D-E-F-Gâ€ƒâ€ƒ(I) in which:A is nonaromatic ring system which can contain from 1 to 4 heteroatoms from the group N, O, and S and can optionally be substituted, once or more than once, by R12, R13, R14, and R15;B is a direct linkage, (C1-C8)-alkanediyl, (C5-C10)-arylene, (C3-C8)- cycloalkylene, â€”Câ‰¡Câ€”, â€”NR2â€”, â€”NR2â€”C(O)â€”, â€”NR2â€”C(O)â€”NR2â€”, â€”NR2â€”C(S)â€”NR2â€”, â€”OC(O)â€”, â€”NR2â€”S(O)â€”, â€”NR2â€”S(O)2â€”, â€”Oâ€”, â€”Sâ€”, or â€”CR2&boxH;CR3â€”, which can in each case be substituted, once or twice , by (C1-C8)-alkyl, where the valance permits; D is a direct linkage, (C1-C8)-alkanediyl, (C5-C10) -arylene, â€”Oâ€”, â€”NR2â€”, â€”COâ€”NR2â€”, â€”NR2â€”COâ€”, â€”NR2â€”C(O)â€”NR2â€”, â€”NR2â€”C(S)â€”NR2â€”, â€”OC(O)â€”, â€”C(O)Oâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”S(O)2â€”NR2â€”, â€”S(O)â€”NR2â€”, â€”NR2â€”S(O)â€”, â€”NR2â€”S(O)2â€”, â€”Sâ€”, â€”CR2&boxH;CR3â€”, or â€”Câ‰¡Câ€” which can in each case be substituted, once or twice, by (C1-C8)- alkyl, â€”CR2&boxH;CR3â€”, or (C5-C6)-aryl, where the valance permits, with it not being possible for D to be â€”COâ€”NR2â€”, â€”C(O)Oâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”S(O)â€”NR2â€”, or â€”S(O)2â€”NR2â€” when B is a direct linkage; E is selected from the group consisting of R1b and R2b are, independent of each other, from one to three groups selected from the group consisting of hydrogen, halogen, cyano, carboxamido, carbamoyloxy, formyloxy, formyl, azido, nitro, ureido, thioureido, hydroxyl, mercapto, sulfonamido, and an optionally substituted radical selected from the group consisting of C1-C12-alkyl, C2-C12-alkenyl, C3-C12-alkynyl, C3-C12-cycloalkyl, C6-C14-aryl, C6-C10-arylâ€”C1-C9- alkyl, C1-C12-alkyloxy, C6-C14-aryloxy, and C1-C12-acylamino, where the substituents are a radical selected from the group consisting of halogen, cyano, azido, nitro, hydroxyl, mercapto, sulfonamido, ureido, thioureido, carboxamido, carbamoyloxy, formyloxy, formyl, C1-C4 alkoxy, phenyl, and phenoxy; and R25b and R26b are, independent of each other, hydrogen, C1-C10-alkyl, C3-C10- alkenyl, C6-C14-aryl, or C1-C6-alkyl â€”C6-C10-aryl, or R25b and R26b together form a trimethylene, tetramethylene, pentamethylene, or 3-oxopentamethylene radical; F is defined like D; G is R2 and R3 are, independent of each other, H, (C1-C10) -alkyl, which is optionally substituted, once or more than once, by fluorine, (C3-C12)-cycloalkyl, (C3-C12)- cycloalkyl-(C1-C8)-alkyl, (C5-C14)-aryl, (C5-C14)-arylâ€”(C1-C8)-alkyl, R8OC(O)R9, R8R8NC(O)R9, or R8C(O)R9; R4, R5, R6, and R7 are, independent of each other, H, fluorine, OH, (C1-C8)- alkyl, (C3-C14)-cycloalkyl, (C3-C14)-cycloalkylâ€”(C1-C8)-alkyl, R8OR9, R8SR9, R8CO2R9, R8 OC(O)R9, R8â€”(C5-C14)-arylâ€”R9, R8N(R2)R9, R8R8NR9, R8N(R2)C(O)OR9, R8S(O)nN(R2)R9, R8OC(O)N(R2)R9, R8C(O)N(R2)R9, R8N(R2)C(O)N(R2)R9, R8N(R2)S(O)nN(R2)R9, R8S(O)nR9, R8SC(O)N(R2)R9, R8C(O)R9, R8N(R2)C(O)R9, or R8N(R2)S(O)nR9; R8 is H, (C1-C8)-alkyl, (C3-C14)-cycloalkyl, (C3-C14)-cycloalkyl-(C1-C8)- alkyl, (C5-C14)-aryl, or (C5-C14)-arylâ€”(C1-C8)-alkyl, where the alkyl radicals can be substituted, once or more than once, by fluorine; R9 is a direct linkage or (C1-C8)-alkanediyl; R10 is C(O)R11, C(S)R11, S(O)nR11, P(O)(R11)n, or a four-membered to eight-membered, saturated or unsaturated heterocycle which contains 1, 2, 3, or 4heteroatoms from the group N, O, and S; R11 is OH, (C1-C8)-alkoxy, (C5-C14)-arylâ€”(C1-C8)-alkoxy, (C5-C14)-aryloxy, (C1-C8)-alkycarbonuloxyâ€”(C1-C4)-alkoxy, (C5-C14)-arylâ€”(C1-C8)-alkylcarbonyloxyâ€”(C1-C6)-alkoxy, NH2, mono- or di-((C1-C8)-alkyl)-amino, (C5-C14)-arylâ€”(C1-C8)- alkylamino, (C1-C8)-dialkylaminocarbonylmethyloxy, (C5-C14)-arylâ€”(C1-C8)- dialkylaminocar-bonylmethyloxy, (C5-C14)-arylamino, or the radical of an L-amino acid or D-amino acid; R12, R13, R14, and R15 are, independent of each other, H, (C1-C10)-alkyl which is optionally substituted, once or more than once, by fluorine, (C3-C12)-cycloalkyl, (C3-C12)- cycloalkylâ€”(C1-C8)-alkyl, (C5-C14)-aryl, C5-C14)-arylâ€”(C1C8)-aryl, -alkyl, H2N, R8ONR9, R8OR9, R8OC(O)R9, R8R8NR9, R8â€”C5-C14)-aryl-R9, HOâ€”(C1-C8)-alkyl-N(R2)R9, R8N(R2)C(O)R9, R8C(O)N(R2)R9, R8C(O)R9, R2R3Nâ€”C(&boxH;NR2)-NR2, R2R3Nâ€”C(&boxH;NR2), &boxH;O, or &boxH;S; where two adjacent substituents from R12 to R15 can also together be â€”OCH2Oâ€” or â€”OCH2CH2Oâ€”; Y is NR2, O, or S; n is 1 or 2; p and q are, independent of each other, 0 or 1; in all their stereoisomeric forms and mixtures thereof in all proportions, and their physiologically tolerated salts.