Patent ID: 8779128
Filing Date: 2014-07-15
Classification: A61K,A61P,C07D,C07F,C07H,C12N

Abstract:
1. An oligomer comprising a backbone, the backbone comprising a sequence of morpholino ring structures joined by intersubunit linkages, the intersubunit linkages joining a 3′-end of one morpholino ring structure to a 5′-end of an adjacent morpholino ring structure, wherein each morpholino ring structure is bound to a base-pairing moiety, such that the oligomer can bind in a sequence-specific manner to a target nucleic acid, wherein the intersubunit linkages have the following general structure (I): or a salt, tautomer or stereoisomer thereof, and wherein each of the intersubunit linkages (I) are independently linkage (A) or linkage (B): wherein for linkage (A): R wherein for linkage (B): W is, at each occurrence, independently S or O; wherein: