Patent ID: 6156342
Filing Date: 2000-12-05
Classification: A61K

Abstract:
A sustained release capsule dosage form comprisinga) at least one controlled release tablet or pellet consisting of:(i) a core consisting of:(1) 10-30% of a drug selected from the group consisting of tramadol or a pharmaceutically acceptable derivative of tramadol;(2) 70-90% of diluent;(3) 0.1-1% of a flow aid;(4) 0.1-1% of a lubricant;(ii) A semipermeable membrane coating covering said core wherein the semipermeable membrane consists of 40-80% of a water insoluble cellulose derivative; 3-15% of a plasticizer; and 5-40% of a means for releasing the drug from the core; andb) at least one immediate release tablet or pellet comprising:(1) a core comprising:(1) 5-100% of a drug selected from the group consisting of tramadol or a pharmaceutically acceptable derivative of tramadol;(2) 0-95% of a diluent;(3) 0-2% a flow aid;(4) 0-2% a lubricant; and(5) optionally a seal coat around the core.