Patent ID: 7429459
Filing Date: 2008-09-30
Classification: A61P,C12Q,G01N

Abstract:
1. A method for identifying a compound that inhibits the processing of amyloid-beta precursor protein in a mammalian cell that expresses amyloid-beta precursor protein and overexpresses a polypeptide comprising the amino acid sequence of SEQ ID NO:4, said method comprising a) contacting a compound with a polypeptide comprising the amino acid sequence of SEQ ID NO:4 wherein said polypeptide is membrane-bound or present as a transmembrane cell receptor in a mammalian cell that expresses amyloid-beta precursor protein; and b) measuring levels of one or more amyloid-beta peptides selected from the group consisting of one or more of amyloid-beta peptide 1-42, 1-40, 11-42 and 11-40; and c) determining if said levels of said one or more amyloid-beta peptides expressed in said mammalian cell that is not contacted with said compound.