Patent ID: 9012717
Filing Date: 2015-04-21
Classification: A01K,C07K,C12N

Abstract:
1. A transgenic mouse whose genome comprises an endogenous λ light chain immunoglobulin locus comprising: i) a deletion of a first endogenous Vλ-Jλ-Cλ gene cluster; and ii) a replacement of a fragment of endogenous Vλ and Jλ gene segments in a second endogenous Vλ-Jλ-Cλ gene cluster with human Vλ and Jλ gene segments, wherein the human Vλ and Jλ gene segments comprise at least one human Vλ gene segment and at least one human Jλ gene segment, and wherein the human Vλ and Jλ gene segments are operably linked to a mouse Cλ gene.