Patent ID: 6503759
Filing Date: 2003-01-07
Classification: B01J,C07B,C07D,C07H,C07K,C40B,G01N

Abstract:
A solid support having bound thereto (i) a compound produced by a single reaction series and (ii) a combination of at least four distinguishable identifiers which differ one from another, at least one which is encompassed by the formula:F1â€”F2â€”(C(Eâ€”Câ€²)a)bâ€ƒâ€ƒIa whereinF1 is CO2H; F2 is A is â€”Oâ€”, OC(O)Oâ€”, â€”OC(O)â€”, or â€”NHC(O)â€”; C is C1-C20 alkylene optionally substituted by 1-40 F, Cl, or Br; Câ€² is F, Cl, C1-C20 alkyl optionally substituted by 1-40 F, Cl, or Br, or C1-C20 alkylene optionally substituted by 1-40 F, Cl or Br, with the proviso that the maximum number of carbon atoms from summing the number of carbons in C and the number of carbons in any Câ€² is 20; E is a mono- or bi-cyclic aromatic ring containing up to 10 carbon atoms and up to 2 heteroatoms selected from O, S, and N, said aromatic ring substituted by 1-7 F, Cl, NO2, SO2R5; R1 is H or C1-C6 alkyl; R5 is C1-C6 alkyl; a is 1-5; b is 1-3; and (i) when b is one, Câ€² is F, Cl, or C1-C20 alkyl optionally substituted by 1-40 F, Cl, or Br; (ii) when b is two or three, internal Câ€²s are C1-C20 alkylene optionally substituted by 1-40 F, Cl, or Br, and terminal Câ€²s are F, Cl, or C1-C20, alkyl optionally substituted by 1-40 F, Cl, or Br; each of said identifiers being bound to said solid support either directly or indirectly or through other than a tag component of another identifier, wherein each identifier or combination thereof encodes information as to a particular choice at a particular stage in the reaction series.