Patent ID: 6165753
Filing Date: 2000-12-26
Classification: A61K,C07K,C12Q,G01N

Abstract:
An isolated biologically active cyclin E2 nucleic acid molecule encoding a polypeptide selected from the group consisting of:(a) the nucleic acid molecule comprising SEQ ID NO:2;(b) the nucleic acid molecule comprising SEQ ID NO:5;(c) the nucleic acid molecule comprising SEQ ID NO:7;(d) the nucleic acid molecule comprising SEQ ID NO:8;(e) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:3;(f) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:4;(g) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:6;(h) a nucleic acid molecule that encodes a polypeptide or a biologically active fragment thereof, wherein said polypeptide or said biologically active fragment is at least 70 percent identical to the polypeptide of SEQ ID NO:3 as calculated using the computer algorithm BLAST2 with its default parameters together with the scoring matrix BLOSUM 62;(i) a nucleic acid molecule that encodes a polypeptide or a biologically active fragment thereof that is at least 70 percent identical to the polypeptide of SEQ ID NO:4 as calculated using the computer algorithm BLAST2 with its default parameters together with the scoring matrix BLOSUM 62;(j) a nucleic acid molecule that encodes a polypeptide or a biologically active fragment thereof that is at least 70 percent identical to the polypeptide of SEQ ID NO:6 as calculated using the computer algorithm BLAST2 with its default parameters together with the scoring matrix BLOSUM 62; and(k) a nucleic acid molecule that hybridizes to any of (a)-(i) above under washing conditions of 0.2.times.SSC and 0.1 percent SDS at a temperature of 50-65.degree. C.