Patent ID: 7018645
Filing Date: 2006-03-28
Classification: A61K,A61P,C08L

Abstract:
1. A biodegradable polymeric system possessing reverse thermal gelation properties comprising a mixture of at least a Component I triblock copolymer and a Component II triblock copolymer, said triblock copolymers comprising biodegradable polyester A-polymer blocks and polyethylene glycol B-polymer blocks, wherein the B-polymer block of said Component I triblock copolymer has an average molecular weight of 900 to 2000 Daltons and the B-polymer block of said Component II triblock copolymer has an average molecular weight of 600 to 2000 Daltons, and wherein said Component I triblock copolymer has an average molecular weight of between 2500 to 8000 Daltons and said component II triblock copolymer has an average molecular weight of between 800-7200 Daltons, and wherein said biodegradable polymeric system is water soluble and contains 51 to 83% by weight of hydrophobic A polymer blocks and 17 to 49% by weight of hydrophilic B polymer blocks wherein an aqueous solution of said Component I triblock copolymer has a lower gelation temperature than an aqueous solution of said Component II triblock copolymer.