Patent ID: 6187568
Filing Date: 2001-02-13
Classification: A61P,C07D,C12P

Abstract:
A macrocyclic lactone compound designated CJ-13,502, made by cultivating a microorganism having the identifying characteristics of Actinoplanes sp. FERM BP-3832, or a mutant or recombinant form thereof, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and having the characteristics of ESI mass spectrum shown in FIG. 3, with m/z 908 [M+Na]+; the UV spectrum shown in FIG. 7, with a UV max at 267, 277 and 288 nm in methanol; and a retention time of 12.8 min. on HPLC using a Pegasil ODS column (4.6.times.150 mm) and eluting with methanol-water (7:3 to 10:0) for 30 min at a flow rate of 0.7 ml/min at 42.degree. C.