Patent ID: 6806282
Filing Date: 2004-10-19
Classification: A61P,C07D

Abstract:
A compound of formula: in which:R1 and R2 represent, each independently of the other, a halogen atom; a (C1-C5)alkyl; a (C1-C5)alkoxy; a nitro, trifluoromethyl or cyano group; an NRaRb amino group in which Ra and Rb represent, each independently of the other, a hydrogen, a (C1-C3)alkyl or a CO(C1-C3)alkyl; or an Sâ€”R group in which R represents a hydrogen atom or a (C1-C5)alkyl, it being possible for the sulphur atom to be monooxidized or dioxidized; R3 represents hydrogen or is as defined above for R1; R4 represents hydrogen; a halogen; a (C1-C5)alkyl; a (C3-C5)cycloalkyl; a (C3-C5)cycloalkyl(C1-C2)alkyl; or an Rcâ€”Xâ€”(C1-C2)alkyl group in which Rc represents hydrogen or a (C1-C3)alkyl and X represents O, S, SO or SO2; R5 represents a (C1-C5)alkyl, an alkynyl with 3 to 5 carbon atoms or an alkenyl with 3 to 5 carbon atoms; a (C3-C5)cycloalkyl(C1-C3)alkyl; or a (C1-C3)alkyl-Xâ€”(C0-C3)alkyl in which X represents O, S, SO or SO2; R6 represents a â€”CHR7R8, in which R7 represents a phenyl group which can be substituted in the 3-, 4- and 5-positions by one or more Zâ€² radicals, with Zâ€² representing a halogen; a nitro, trifluoromethyl or cyano group; a (C1-C5)alkyl; a (C1-C5)alkyl-Xâ€” or (C1-C3)alkyl-Xâ€”(C1â€”C2)alkyl where X represents O, S, SO or SO2; a hydroxy(C1-C3)alkyl; a CORd or COORd in which Rd is as defined above; a methylenedioxy or an ethylenedioxy; R8 represents a (C3-C5)cycloalkyl(C1-C3)alkyl; or a pharmaceutically acceptable addition salt, hydrate and/or solvate thereof.