Patent ID: 6767711
Filing Date: 2004-07-27
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
A method of detecting normal, benign, hyperplastic, and cancerous prostate epithelial cells or a portion thereof in a biological sample comprising:providing an antibody or binding portion thereof which recognizes an antigen on the surface of said cells, wherein the antibody or binding portion thereof binds to an epitope of a prostate-related antigen which is also recognized by a monoclonal antibody selected from the group consisting of monoclonal antibodies produced by hybridoma cell lines having ATCC Designations HB 11424, HB 11425, HB 11427, HB 11892, and HB 11893, and wherein the antibody or binding portion thereof is bound to a label effective to permit detection of said cells or a portion thereof upon binding of the antibody or binding portion thereof to said antigen; contacting the biological sample with the antibody or binding portion thereof having a label under conditions effective to permit binding of the antibody or binding portion thereof to said antigen on any of said cells or a portion thereof in the biological sample; and detecting the presence of any of said cells or a portion thereof in the biological sample by detecting the label.