Patent ID: 6077861
Filing Date: 2000-06-20
Classification: A61P,C07D

Abstract:
A compound of the Formula (1) ##STR92## wherein ""Het"" is a moiety selected from the group consisting of (A) through (H): ##STR93## wherein Z is independently for each occurrence selected from O or S;R.sup.a, R.sup.b and R.sup.c each are independently selected from hydrogen, halogen, OH, CF.sub.3, NO.sub.2, or ##STR94## provided R.sup.c is not hydrogen; and when R.sup.a and R.sup.b are hydrogen, R.sup.c may be a heterocyclic moiety selected from the group consisting of imidazol-1-yl, morpholinomethyl, N-methylimidazol-2-yl, and pyridin-2-yl;R.sup.d and R.sup.e each are independently selected from hydrogen, halogen, CF.sub.3, NO.sub.2 or imidazol-1-yl;m, n and p each are independently selected from an integer of O or 1; andR.sup.f and R.sup.g each are independently hydrogen; C.sub.1-4 alkyl; or R.sup.f and R.sup.g, taken together with the nitrogen atom to which they are attached, is a heterocyclic moiety selected from the group consisting of N-methylpiperazine, morpholine, thiomorpholine, N-benzylpiperazine and imidazolinone;or a nontoxic pharmaceutically acceptable salt or solvate thereof.