Patent ID: 6482837
Filing Date: 2002-11-19
Classification: A61K

Abstract:
A method for treating bladder disease in a subject, comprising:administering to the bladder of said subject an effective amount of a composition that comprises a chemical compound having the following properties: (a) binds selectively to muscarinic receptors in the bladder when compared to non-muscarnic receptors; (b) is a glycolate ester of a heterocyclic amino alcohol of the general formula â€ƒor a salt thereof, wherein R1 is a heterocyclic N-substituted ring; Y is a chemical bond or a lower alkyl group; Z is O or S; R2 is OH, Cl, an acyl alcohol group or an acyl chloride group; R3 and R4 are, independently, a substituted or unsubstituted phenyl, a substituted or unsubstituted cycloalkyl, a straight or branched chain alkyl, alkenyl or alkynyl, and further, one of R3 and R4 may be H with the proviso that said compound is not a quinuclidinyl derivative, glycopyrrolate, or trospium chloride.