Patent ID: 7892540
Filing Date: 2011-02-22
Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
1. A method for the treatment of a subject with cancer, wherein some or all cells of the cancer or some or all tumor-infiltrating leukocytes in cancer tissue express B7-H1, comprising administering to the subject an agent which is an antibody or an antigen-binding antibody fragment that interferes with an interaction between B7-H1 and a receptor for B7-H1, wherein said subject is a human or mouse and said B7-H1 is human B7-H1 (hB7-H1) or mouse B7-H1 (mB7-H1), respectively, wherein said subject has been identified for said administration by a test on a sample of cancerous tissue from said subject, wherein said tissue sample contains test cells, said test cells being cancer cells or tumor-infiltrating leukocytes, and said test was an assessment of the level of test cells in the tissue sample that express B7-H1, said identification being made if, the level of test cells in the tissue sample that express said B7-H1 is less than an immuno-inhibitory threshold level, wherein said immuno-inhibitory threshold level is determined by performing a statistical analysis of the correlation between the proportion of cells expressing B7-H1 in a group of subjects with said cancer and an expected risk of death in said group of subjects, and assigning a statistically significant cut-off value for said correlation.