Patent ID: 6300321
Filing Date: 2001-10-09
Classification: A61K,C07C,C12N

Abstract:
A compound comprising lipopolyamine in D, L or DL form, as well as its salts, of general formula (I): ##STR17##in which:R.sub.1, R.sub.2 and R.sub.3 represent, independently of each other, a hydrogen atom or a group --(CH.sub.2).sub.q --NRR' withq being an integer from 1 to 6 inclusive, the values of q being independent of each other between the different groups R.sub.1, R.sub.2 and R.sub.3, andR and R' represent, independently of each other, a hydrogen atom or a group of formula (II): ##STR18##in which r is an integer which may vary from 0 to 6 inclusive, and the R.sub.5 groups represent, independently of each other, a hydrogen atom or a hydrocarbon residue, it being understood that at least one of the groups R.sub.1, R.sub.2 and R.sub.3 contains at least one group of formula (II);m and n represent, independently of each other, an integer which may vary from 1 to 6 inclusive and, when n is greater than 1, m may have different values and R.sub.3 different meanings within the general formula (I),p represents an integer which may vary between 1 and 6 inclusive, andR.sub.4 represents a group of general formula (III): ##STR19##in which:R.sub.7 and R.sub.8 represent, independently of each other, a hydrogen atom or a lipophilic group, at least one of the groups R.sub.7 and R.sub.8 being different from hydrogen,t is an integer chosen from 0 to 10 inclusive with R.sub.6, X, Y and s may have different meanings within the different units [X-(CHR.sub.6).sub.s --Y] when t is an integer greater than 1,X represents an oxygen or sulphur atom or an amine or alkylamino group, the alkyl substituent being linear or branched and containing 1 to 8 carbon atoms,Y represents a carbonyl group or a methylene group,R.sub.6 represents a hydrogen atom or a natural amino acid side chain, substituted where appropriate ands represents an integer varying from 1 to 10 inclusive with, when s is equal to 1, R.sub.6 representing a natural amino acid side chain optionally substituted, and when s is greater than 1, R.sub.6 representing a hydrogen atom.