Patent ID: 6825206
Filing Date: 2004-11-30
Classification: A61K,C07D,C07K

Abstract:
A compound comprising: wherein R1 and R2, are each independently NO2, NH2, H, F, Cl, Br, I, COOH, OH, Oâ€”C1-6 alkyl, SH, Sâ€”C1-6 alkyl, CN, NHâ€”C1-6 alkyl, N(C1-6 alkyl)2, CHO, C1-8 alkyl, N3, â€”Zâ€”(CH2)aâ€”Nâ€”((CH2)bOH)2, wherein Z is selected from the group consisting of O, NH and S, and a and b are each independently an integer of 2 or 3, â€”Zâ€”(CH2)aâ€”Nâ€”(C1-6 alkyl)2 wherein Z is selected from the group consisting of O, NH and S, and a is an integer of 2 or 3, â€”CH2NR4R5, where (a) R4 and R5 are, independently, hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6 alkyl, C2-6 alkenyl, hydroxy-C1-6 alkyl, C1-6 alkoxy-C1-6 COR6 where R6 is hydrogen, C1-6 alkyl, perhalo-C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6 alkyl, C2-6 alkenyl, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, or (b) R4 and R5 taken together with the nitrogen atom to which they are attached form a saturated 3-7 membered heterocyclic ring which may contain a O, S or NR7 group, where R7 is hydrogen, C1-6 alkyl, perhalo-C1-6 alkyl, aryl, aryl substituted with one or more groups selected from the group consisting of C1-6 alkyl, halogen, nitro, amino, C1-6 alkylamino, perhalo-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl and â€”COR8 where R8 is hydrogen, C1-6 alkyl perhalo-C1-6 alkyl, C1-6 alkoxy, aryl, and aryl substituted with one or more C1-6 alkyl, perhalo-C1-6 alkyl, hydroxy-C1-6 alkyl, or C1-6 alkoxy-C1-6 alkyl groups; R3 is H; or or R2 and R3 combine to form a ring where R9 and R10 are each independently H or F and n is an integer of 1 or 2; R11 is H, or C(O)â€”(CH2)mNR12R13, where m is an integer of 1-6 or â€”C(O)CHR14NR12R13, where R14 is the side chain of one of the naturally occurring -amino acids, R12 and R13 are, independently, hydrogen, C1-8 alkyl or â€”C(O)CHR15NR16R17, where R15 is the side chain of one of the naturally occurring -amino acids and R16 and R17 are each independently hydrogen or C1-8 alkyl; R18 is OR19 or R19OC(O)â€”(CH2)mâ€”NR20, or R21OC(O)CHR22NR20, where R19 is H or C1-6 alkyl, m is an integer of 1-6, R22 is the side chain of one of the naturally occurring -amino acids, R20 is hydrogen, C1-8 alkyl or â€”C(O)CHR23NR24R25, where R23 is the side chain of one of the naturally occurring -amino acids and R24 and R25 are each independently hydrogen or C1-8 alkyl; R26 is H or where R27 is H or C1-6 alkyl; and X is S or O, or a pharmaceutically acceptable salt thereof.