Patent ID: 8288432
Filing Date: 2012-10-16
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method for the treatment of a disease or condition selected from cardiovascular diseases, respiratory disorders, disorders affecting the metabolism, skin and/or bone diseases, kidney diseases, reproduction disorders, inflammatory disorders, allergic disorders, traumatisms, septic, hemorrhagic and anaphylactic shock, cancers, diseases or disorders of the gastrointestinal system and other diseases and/or disorders associated with Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase) catalyzed production of reactive oxygen species (ROS) comprising administering a tetrahydroindole derivative according to Formula (I) in a patient having a disease or condition selected from cardiovascular diseases, respiratory disorders, disorders affecting the metabolism, skin and/or bone diseases, kidney diseases, reproduction disorders, inflammatory disorders, allergic disorders, traumatisms, septic, hemorrhagic and anaphylactic shock, cancers, diseases or disorders of the gastrointestinal system and other diseases and/or disorders associated with Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase) catalyzed production of reactive oxygen species (ROS): wherein G 1 is selected from the following groups: G G A B D R R R R R and pharmaceutically acceptable salts or pharmaceutically active derivatives and tautomers thereof.