Patent ID: 6036957
Filing Date: 2000-03-14
Classification: A61K,A61P,C07K

Abstract:
A method for suppressing immune function of CD4+T-cells reactive with myelin basic protein in a human afflicted with multiple sclerosis comprising administering to said human via the intravenous route a peptide, the amino acid sequence of which is all or a segment of the sequence SLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLS provided that said sequence comprises a portion of DENPVVHFFKNIVTPRTPP sufficient to impart to said peptide the property of stimulating, as determined by proliferation assay, the subgroup of HLA-DR2b restricted T-cell clones from remitting-relapsing multiple sclerosis patients that is reactive with another peptide the sequence of which consists of DENPVVHFFKNIVTPRTPP, said peptide stimulating said subgroup of T-cells to about the same degree as said another peptide.