Patent ID: 6703405
Filing Date: 2004-03-09
Classification: C07D

Abstract:
A compound of the formula I wherein:R1, R2, R3 and R4 are independently of one another H, F, Cl, Br, I, CN, NO2, OH, NH2, CaH2a+1, CqqH2qqâˆ’1, OCbH2b+1, COOR50, OCOR50, COR50 or Oxâ€”(CH2)y-phenyl; wherein a and b are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8, wherein the groups CaH2a+1 and OCbH2b+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms; qq is 3, 4, 5, 6, 7 or 8, wherein the group CqqH2qqâˆ’1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; R50 is H or CcH2c+1, c is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CcH2c+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; x is zero or 1; y is zero, 1, 2, 3 or 4, where the phenyl ring in the group Oxâ€”(CH2)y-phenyl is unsubstituted or substituted by 1-3 independently chosen from F, Cl, Br, CN, NO2, OH, NH2 and CdH2d+1, d is 1, 2, 3 or 4, wherein the group CdH2d+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R1, R2, R3 and R4 are independently of one another chosen from a heteroaryl with at least one heteroatom chosen from 1, 2, 3 or 4 N atoms, 1 oxygen atom and 1 S atom, present as a ring atom; or R1, R2, R3 and R4 are independently of one another CONR11R12 or NR11R12; wherein R11 and R12 are independently of one another H, CeH2e+1 or CrrH2rrâˆ’1, e is 1, 2, 3, 4, 5, 6, 7 or 8; rr is 3, 4, 5, 6, 7, or 8, wherein the groups CeH2e+1 and CrrH2rrâˆ’1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms and/or one or more CH2 groups are replaced by O or NR13; R13 is H or CfH2f+1; f is 1, 2, 3 or 4, wherein the group CfH2f+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R13 and a CH2 group of R11 or R12 together with the N atom to which they are bonded form a 5- or 6-membered ring; or R11 and R12 together with the N atom to which they are bonded form a 5-, 6- or 7-membered ring; or R11 and R12 are independently of one another COR14, CSR14 or SO2R14; wherein R14 is CgH2g+1; g is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CgH2g+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms, and/or one or more CH2 groups are replaced by O or NR13; or R1, R2, R3 and R4 are independently of one another â€”Ohâ€”SOjâ€”R15; wherein h is zero or 1; j is zero, 1 or 2; R15 is CkH2k+1, OH, OClH2l+1 or NR17R18; k is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CkH2k+1 is unsubsitituted or substituted where one or more H atoms are replaced by F atoms; l is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group OClH2l+1 is unsubsitituted or substituted where one or more H atoms are replaced by F atoms; R17 and R18 are independently of one another H or CmH2m+1; m is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CmH2m+1 is unsubstituted or substituted where one or more H atoms is replaced by F atoms and/or one or more CH2 groups are replaced by O, CO, CS or NR19; R19 is H or CnH2n+1; n is 1, 2, 3 or 4, wherein the group CnH2n+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R17 and R18 together with the N atom to which they are bonded form a 5-, 6- or 7-membered ring; or R19 and a CH2 group of R17 or R18 together with the N atom to which they are bonded form a 5- or 6-membered ring; with the proviso that R2 is not H; R5 and R6 are independently of one another CpH2p+1, CssH2ssâˆ’1, COR20 or SO2R20; wherein p is 1, 2, 3, 4, 5, 6, 7 or 8; ss is 3, 4, 5, 6, 7 or 8; R20 is CqH2q+1; q is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the groups CpH2p+1, CssH2ssâˆ’1 and CqH2q+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms and/or one or more CH2 groups are replaced by O or NR21; R21 is H or CrH2r+1; r is 1, 2, 3 or 4; wherein the group CrH2r+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; R7 is H, F, Cl, Br, I, CsH2s+1, CddH2ddâˆ’1, OH, OCtH2t+1 or OCOR22; wherein s and t are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8; dd is 3, 4, 5, 6, 7 or 8, wherein the groups CsH2s+1, CddH2ddâˆ’1 and OCtH2t+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms; R22 is CuH2u+1; u is 1, 2, 3 or 4, wherein the group CuH2u+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; R8, R9 and R10 are independently of one another â€”Ovâ€”SOwâ€”R23; wherein v is zero or 1; w is zero, 1 or 2; R23 is CnnH2nn+1, CmmH2mmâˆ’1, OH, OCppH2pp+1 or NR25R26; nn and pp are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8, mm is 3, 4, 5, 6, 7 or 8, wherein the groups CnnH2nn+1, CmmH2mmâˆ’1 and OCppH2pp+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms; R25 and R26 are independently of one another H, CN, CzH2z+1, or CzzH2zzâˆ’1; z is 1, 2, 3, 4, 5, 6, 7 or 8; zz is 3, 4, 5, 6, 7 or 8, wherein the group CzH2z+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms and, wherein the group CzH2z+1, is unsubstituted or substituted where one or more H atoms are replaced by F atoms and/or one or more CH2 groups are replaced by O, CO, CS or NR27; R27 is H or CaaH2aa+1; aa is 1, 2, 3 or 4, wherein the group CaaH2aa+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R27 and a CH2 group of R25 or R26 together with the N atom to which they are bonded form a 5- or 6-membered ring; or R25 and R26 together with the N atom to which they are bonded form a 5-, 6- or 7-membered ring, or R8, R9 and R10 are independently of one another NR32COR30, NR32CSR30 or NR32SObbR30; wherein R30 is H, CccH2cc+1, CyyH2yyâˆ’1, pyrrolidinyl or piperidinyl, wherein the pyrrolidinyl or piperidinyl is unsubstituted or substituted where a CH2 group is replaced by O or NR33; R32 and R33 are independently of one another H or ChH2h+1; bb is 2 or 3; cc is 1, 2, 3, 4, 5, 6, 7 or 8; yy is 3, 4, 5, 6, 7 or 8; h is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group ChH2h+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms, and wherein the groups CccH2cc+1 and CyyH2yyâˆ’1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms and/or one or more CH2 groups are replaced by O or NR31; R31 is H, CkkH2kk+1, or COR65; kk is 1, 2, 3, or 4; wherein the group CkkH2kk+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms, R65 is H, or CxxH2xx+1; xx is 1, 2, 3 or 4, wherein the group CxxH2xx+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R31 together with a CH2 group of R30 and the N atom to which they are jointly bonded forms a 5-, 6- or 7-membered ring; or R30 is a 5- or 6-membered heteroaryl with at least one hetero atom chosen from 1, 2, 3 or 4 N atoms, 1 S atoms and 1 O atoms which is unsubstituted or substituted by up to three substituents chosen from F, Cl, Br, I, CooH2oo+1, and NR70R71; R70 and R71 are independently of one another H, CuuH2uu+1 or COR72 R72 is H, or CvvH2vv+1; oo, uu and vv are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8, wherein the groups CooH2oo+1, CuuH2uu+1 and CvvH2vv+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R8, R9 and R10 are independently of one another H, F, Cl, Br, I, NO2, CN, OH, NH2, CeeH2ee+1, CwwH2wwâˆ’1, OCffH2ff+1, NR40R41, CONR40R41, COOR42, COR42 or OCOR42; ee and ff are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8; ww is 3, 4, 5, 6, 7 or 8, wherein the groups CeeH2ee+1, CwwH2wwâˆ’1 and OCffH2ff+1 independently of one another are unsubstituted or substituted where one or more H atoms are replaced by F atoms; R40 and R41 are independently of one another H or CttH2tt+1; tt is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CttH2tt+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms and/or where one or more CH2 groups are replaced by O or NR44; R44 is H or CggH2gg+1; gg is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group CggH2gg+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; or R40 and R41 with the N atom to which they are bonded for a 5- or 6-membered ring; R42 is H or ChhH2hh+1; hh is 1, 2, 3, 4, 5, 6, 7 or 8, wherein the group ChhH2hh+1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; Y is chosen from fluorine, chlorine, bromine, iodine, hydroxyl and all anionic forms of pharmacologically acceptable mono-, di- or tricarboxylic acids and sulfonic acids; or a pharmaceutically acceptable salt thereof, or a trifluoroacetic acid salt thereof, in any stereoisomeric form, or a mixture of any such compounds in any ratio.