Patent ID: 7919257
Filing Date: 2011-04-05
Classification: A61P,C07K,G01N

Abstract:
1. A method for selecting a single recombinant cell that expresses a heterogeneous combination of monospecific and bispecific antibodies, or antibody fragments thereof, wherein the monospecific and bispecific antibodies, or antibody fragments thereof, are human, humanized, or deimmunized, and wherein the heterogeneous combination has specific affinity for two target epitopes, said method comprising: carrying out a process for producing the heterogeneous combination; the process comprising providing two target epitopes, selecting a single recombinant cell from said recombinant cells that produces a heterogeneous combination that binds the two target epitopes, and co-purifying the heterogeneous combination therefrom utilizing a shared feature of each of the monospecific and bispecific antibodies, or antibody fragments thereof.