Patent ID: 7053102
Filing Date: 2006-05-30
Classification: C07D

Abstract:
1. A pharmaceutical composition for treating colon and breast cancer in warm-blooded animals comprising an amount of an unsubstituted or pharmaceutically acceptable substituted camptothecin with a 7-ring member β-hydroxy lactone ring of the formula wherein R 1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, alkoxy alkyl of 2 to 12 carbon atoms and alkylthioalkyl of 2 to 12 carbon atoms, R p is hydrogen or an easily cleavable group, R 18 and R 19 are individually selected from the group consisting of hydrogen, halogen, OH and alkyl and alkoxy of 1 to 6 carbon atoms and its non-toxic, pharmaceutically acceptable salts sufficient to treat colon and breast cancer and a pharmaceutical carrier.