Patent ID: 9169504
Filing Date: 2015-10-27
Classification: C12N,C12P,C12Y

Abstract:
1. A method for producing pyripyropene A, comprising: culturing a microorganism in the presence of pyripyropene E to produce pyripyropene A and isolating the pyripyropene A, wherein said microorganism is transformed with at least one heterologous polynucleotide in (I) to (Ill) below or a recombinant vector comprising said heterologous polynucleotide: (I) a heterologous polynucleotide having at least one nucleotide sequence selected from the nucleotide sequences in (a) to (d) below: (II) a heterologous polynucleotide having a nucleotide sequence encoding the amino acid sequences of SEQ ID NOs: 267-275 or an amino acid sequence having one to ten substituted, deleted, added, or inserted residues in the amino acid sequences of SEQ ID NOs: 267-275 and having the same enzymatic activity as the amino acid sequences set forth in SEQ ID NOs: 267-275, respectively, (III) a heterologous polynucleotide having at least one nucleotide sequence selected from the group consisting of the nucleotide sequences set forth in (1) to (4) below: