Patent ID: 6642267
Filing Date: 2003-11-04
Classification: A61P,C07D

Abstract:
A substituted 1,5-dihydropyrrol-2-one compound of formula I: wherein X represents O or NR7; R1 represents H, OR11, SR11, COR8, CSR8, NR9R10, COOR8, CONR9R10, CSNR9R10, COCOR8, a C1-10-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-6-alkylene group; R2, R3, which are identical or different, represent H, F, Cl, Br, CF3, OR11, SR11, NR9R10, a C1-10-alkyl, an aryl or a heteroaryl group, or represent an aryl group bonded via a C1-10-alkylene group; R4 represents H, OH, OR11, SR11, COR8, COOR8, COCOR8, CONR9R10, CSNR9R10, a C1-6-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-6-alkylene group; R5, R6, which are identical or different, represent H, O, OH, OR11, SR11, CSR8, COOR8, COCOR8, CONR9R10, CSNR9R10, a C1-10-alkyl, an aryl or a heteroaryl group, or represent an aryl group bonded via a C1-6-alkylene group or R5 and R6 together denote the group &boxH;O; R7 represents H, OR11, SR11, COR8, COOR8, COCOR8, CONR9R10, CSNR9R10, a C1-10-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-6-alkylene group; R8 represents H, OR11, SR11, NR9R10 a C1-10-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-10-alkylene group; R9 represents a C1-10-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-6-alkylene group; R10 represents a C1-10-alkyl, an aryl or heteroaryl group, or represents an aryl group bonded via a C1-6-alkylene group; and R11 represents a C1-10-alkyl, an aryl or a heteroaryl group, or represents an aryl group bonded via a C1-10-alkylene group; in the form of their racemates, enantiomers, diastereomers or a corresponding physiologically tolerated salt.