Patent ID: 8772305
Filing Date: 2014-07-08
Classification: A61P,C07D

Abstract:
1. A compound of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein ring A may optionally be further substituted by one or two residues which are both independently from each other selected from the group consisting of H, halogen, C and wherein R H, -halogen, SH, -oxo, —NH with Y being a group selected from the group consisting of —NH or with Y being a group selected from the group consisting of a four-, five-, six- or seven-membered monocyclic fully saturated or partially unsaturated heterocycle comprising 1, 2 or 3 heteroatoms each independently selected from the group N, S and O, with the proviso that this heterocycle comprises at least one N-atom and that this heterocycle is directly attached to the molecule via this N-atom, a five- or six-membered monocyclic heteroaromatic group comprising 1, 2 or 3 heteroatoms each independently selected from the group of N, S and O, and a C or with Y being a 9- to 11-membered bicyclic annellated fully saturated or partially unsaturated heterocycle comprising 1, 2, 3 or 4 heteroatoms each independently from each other selected from the group N, S and O, or with Y being an 8- to 11-membered bicyclic fully saturated spiro-heterocycle comprising 1, 2 or 3 heteroatoms each independently selected from the group N, S and O, with the proviso that this spiro-heterocycle comprises at least one N-atom and that this heterocycle is directly attached to the molecule via this N-atom, or with Y being a six- or seven-membered fully saturated heterocycle comprising 1, 2 or 3 heteroatoms each independently selected from the group N, S and O, which is bridged by an additional C whereby each Y may optionally be substituted by one or more groups Z each independently from each other selected from the group consisting of halogen, -oxo, OH, C whereby each group Z may optionally be further substituted by one, two or three groups T each independently selected from the group consisting of -oxo, OH, halogen, —C wherein each group T may also optionally be substituted by a group selected from the group consisting of C whereby L denotes a 5- or 6-membered fully saturated or partially unsaturated heterocycle comprising 1 or 2 heteroatoms each independently selected from the group N, O and S, which said heterocycle may optionally be substituted by one, two or three groups independently selected from among methyl, halogen, OH and -oxo, wherein R or R wherein each R wherein R wherein R wherein R or a pharmaceutically acceptable salt thereof.