Patent ID: 6251433
Filing Date: 2001-06-26
Classification: A61K,A61P,C07K,C12N

Abstract:
A polycationic agent having the following formula: ##STR38##whereinn is an integer from 10 to 100 resulting in a repeating trimer wherein two R.sub.1 groups of each trimer are neutral and one R.sub.1 group of each trimer is cationic;R.sub.2 and R.sub.3 are hydrogen for each monomer: ##STR39##T.sub.a and T.sub.c are terminating groups;said cationic R.sub.1 groups are selected from the group consisting of ammoniumalkyl, aminoalkyl, guanidinoalkyl, amidinoalkyl, aminocyclohexyl, piperidyl, guanidinobenzyl, guanidino-.alpha.-methylbenzyl, amidinobenzyl, amidino-.alpha.-methylbenzyl, an aliphatic hydrazide, an aromatic hydrazide; pyridylmethyl, wherein the pyridyl ring is optionally further substituted with a group selected from methyl, methoxy, fluoro, chloro, bromo, and nitro; and aminobenzyl, wherein the benzyl ring is optionally further substituted with a group selected from methyl, methoxy, fluoro, chloro, bromo, and nitro;wherein ""ammonium"" is trimethylammonium, triethylammonium, methyldiethylammonium, or ethyldimethylammonium, and ""alkyl"" is --CH(R)--(CH.sub.2).sub.m --, where R is H or Me, and m is 1-6;and said neutral R.sub.1 groups are selected from the group consisting of a neutral moiety comprising an aromatic ring and having a molecular weight of 250 daltons or less, cyclohexyl methyl, 2-methoxyethyl, and 6-galactosyl;wherein said polycationic agent comprises at least 25% positively charged monomers, excluding the terminating groups, andwherein said polycationic agent exhibits a net positive electrical charge at a physiological pH.