Patent ID: 6432973
Filing Date: 2002-08-13
Classification: A61K,A61P,C07D

Abstract:
A compound having the structure whereinR1 and R2 are each, independently, hydrogen or â€”CO(CR3R4)b(CR5R6)dCR7R8R9; R3 and R4 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, trifluoromethyl, or â€”F; R5 and R6 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, â€”(CR3R4)fOR10, â€”CF3, â€”F, or â€”CO2R11; R7 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, â€”(CR3R4)fOR10, â€”CF3, â€”F, or â€”CO2R11; R8 and R9 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, â€”(CR3R4)fOR10, â€”CF3, â€”F, or â€”CO2R11; R10 is hydrogen or â€”COCH2â€”Sâ€”CH2CH2â€”(Oâ€”CH2â€”CH2)nâ€”OCH3; R11 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, or phenylalkyl of 7-10 carbon atoms; b=0-6; d=0-6; f=0-6; n=5-450; with the proviso that R1 and R2 are both not hydrogen and further provided that either R1 or R2 contains at least one â€”(CR3R4)fOR10 group in which R10 is â€”COCH2â€”Sâ€”CH2CH2â€”(Oâ€”CH2â€”CH2)nâ€”OCH3, or a pharmaceutically acceptable salt thereof.