Patent ID: 6437119
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
Process for preparing a compound from a plurality of antibiotics comprising, in sequence:a. treating a quinolone selected from the group consisting of nalidixic acid, perfloxacin, and ofloxacin with thionyl chloride to produce the corresponding quinolone acid chloride; b. condensing said quinolone acid chloride in a solvent consisting of pyridine, with a &bgr;-lactam selected from the group consisting of cephalosporins selected from the group consisting of cephalexin, cephradine, cefadroxil, cefaclor, cefloxamin, ceftriaxone and ceftizoxime and penicillins selected from the group consisting of ampicillin and amoxicillin to form a compound having two antibiotic functions and HCl; c. adding a stoichiometric quantity of bicarbonate of sodium to neutralize the HCl formed in step (b) and forming CO2 and an inert alkali or alkaline earth metal chloride and said compound having two antibiotic functions: d. removing the solvent used in step (b) and the CO2 formed in step (c) by evaporation in vacuo to isolate said compound having two antibiotic functions and said inert chloride.