Patent ID: 7056729
Filing Date: 2006-06-06
Classification: A61K,A61P,C07K

Abstract:
1. A plasmid encoding a modified clostridial neurotoxin, comprising: (a) a first nucleotide sequence comprising; (i) a first nucleotide segment encoding an amino acid sequence comprising substance P as the targeting moiety; and (ii) a second nucleotide segment encoding an amino acid sequence comprising a translocation domain (H wherein the first and second nucleotide segments encode an amino acid sequence comprising a fusion protein of a translocation domain and substance P. and wherein the H (b) a second nucleotide sequence encoding an amino acid sequence comprising the L-chain or an L-chain fragment of a clostridial neurotoxin, which L-chain fragment comprises the active protease domain of L-chain and (c) an element for plasmid replication by a host cell.