Patent ID: 7658919
Filing Date: 2010-02-09
Classification: A61K,A61P,C07K

Abstract:
1. A fusion polypeptide comprising a first polypeptide operably linked to a second polypeptide, wherein the first polypeptide is glycosylated a. on O-linked glycans by an α1,¾ fucosyltransferase, an α1,2 fucosyltransferase, a β1,3 galactosyltransferase and a β 1,3, N-acetylglucosaminyltransferase, or b. on N-linked glycans by an α1,¾ fucosyltransferase, an α1,2 fucosyltransferase and a β1,3 galactosyltransferase; and c. comprises multiple Le and the second polypeptide comprises at least a region of an immunoglobulin polypeptide.