Patent ID: 6599873
Filing Date: 2003-07-29
Classification: A61K,C07K

Abstract:
An interleukin-1 inhibitor (IL-1i), comprising a glycosylated or nonglycosylated polypeptide having interleukin-1 (IL-1) inhibitory activity and being free of other human protein, wherein said polypeptide is selected from the group consisting of:A) a polypeptide comprising all or an IL-1 inhibitory fragment of the amino acid sequence: (U) (X) P S G R K S S K M Q A F R I W D V N Q K T F Y L R N N Q L V A G Y L Q G P N V N L E E K I D V V P I E P H A L F L G I H G G K M C L S C V K S G D E T R L Q L E A V N I T D L S E N R K Q D K R F A F I R S D S G P T T S F E S A A C P G W F L C T A M E A D Q P V S L T N M P D E G V M V T K F Y F Q E D Eâ€ƒwherein (U) is M or nothing and (X) is R or P; and B) a polypeptide that is at least about 90% homologous to the amino acid sequence set forth in A).