Patent ID: 8486391
Filing Date: 2013-07-16
Classification: A61K,A61P,C07K

Abstract:
1. A kit comprising, in a pharmaceutically acceptable form, an amount of at least a first anti-cancer agent effective to kill at least a portion of tumor vascular endothelial cells, promote coagulation in at least a portion of tumor blood vessels, occlude or destroy at least a portion of tumor blood vessels, induce necrosis in at least a portion of a tumor, induce tumor regression or induce tumor remission upon administration to an animal having a vascularized tumor, wherein said at least a first anti-cancer agent is at least a first isolated or purified unconjugated antibody, including the Fc portion of said antibody, that binds to an aminophospholipid or aminophospholipid-protein complex on the luminal surface of the vascular endothelial cells of the blood vessels of said vascularized tumor; and at least a second anti-cancer agent other than said at least a first isolated or purified unconjugated antibody.