Patent ID: 6124334
Filing Date: 2000-09-26
Classification: C07D

Abstract:
A compound structurally represented by formula I or pharmaceutically acceptable salts thereof wherein:Q is a benzoannulated hetero-aromatic 5-member ring bonded to the phenyl ring of formula I at the nitrogen of the structures xiv or xv: ##STR6## R.sup.1 is independently H, --OCH.sub.3, F, or Cl; R.sup.2 is(a) hydrogen,(b) C.sub.1 -C.sub.8 alkyl optionally substituted with one or more of the following F, Cl, hydroxy, C.sub.1 -C.sub.8 alkoxy, or C.sub.1 -C.sub.8 acyloxy,(c) C.sub.3 -C.sub.6 cycloalkyl,(d) amino,(e) C.sub.1 -C.sub.8 alkylamino,(f) C.sub.1 -C.sub.8 dialkylamino, or(g) C.sub.1 -C.sub.8 alkoxy;R.sup.3 is each independently selected from(a) H,(b) F, Cl, Br,(c) --OR.sup.4,(d) --SR.sup.4,(e) --S(O).sub.n R.sup.4 (n is 1 or 2),(f) --CN,(g) --O.sub.2 CR.sup.4,(h) --NHCOR.sup.4,(i) --NHCO.sub.2 R.sup.4,(j) --NHSO.sub.2 R.sup.4,(k) --CO.sub.2 R.sup.4,(l) --CON(R.sup.4).sub.2,(m) --COR.sup.4,(n) C.sub.1 -C.sub.8 straight or branched chain alkyl or C.sub.3 -C.sub.8 cycloalkyl, optionally substituted with one or more of (a)-(m),(o) Phenyl, optionally substituted with one or more of the preceding groups listed under (a)-(n),(p) --CH.dbd.CHCO.sub.2 Et, or(q) --C(.dbd.NR.sub.5)R.sub.6, wherein R.sub.5 is --OH or OCH.sub.3, wherein R .sub.6 is H or CH.sub.3 ; andR.sup.4 is(a) H,(b) C.sub.1 -C.sub.6 straight or branched chain alkyl or C.sub.3 -C.sub.8 cycloalkyl, optionally substituted with one or more fluorine, chlorine, hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 acyl, C.sub.1 -C.sub.4 acyloxy, or O.sub.2 CCH.sub.2 N(CH.sub.3).sub.2, or(c) Phenyl, optionally substituted with one or more of fluorine, chlorine, C.sub.1 -C.sub.4 straight or branched chain alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 acyl, C.sub.1 -C.sub.4 acyloxy, or O.sub.2 CCH.sub.2 N(CH.sub.3).sub.2.