Patent ID: 9012693
Filing Date: 2015-04-21
Classification: C07B,C07C

Abstract:
1. A process for the preparation of a compound of formula (I) comprising a step in which (i) a compound of formula (II) is reacted with a compound of formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a palladium catalyst; (ii) if necessary, converting X into a leaving group; (iii) reacting with a compound (V) or (VI) wherein Ar is aryl and m is independently as hereinbefore defined in the presence of a base; (iv) reducing the —SO (v) converting the diprotected naphthoquinone into a naphthoquinone.