Patent ID: 7256186
Filing Date: 2007-08-14
Classification: C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt, solvate or ester thereof, wherein: (A) R (B) R (C) Each R (D) Each R (E) R (F) X is selected from the group consisting of: (G) Y is selected from the group consisting of: wherein the aryl moiety in said substituted groups (12), (14), (15), (18), and (21) of said Y group, and the heteroaryl moiety in said substituted groups (13), (16), (17) and (20) of said Y group, are substituted with one or more substituents independently selected from the group consisting of: (a) halo; (b) —CF (c) —OH; (d) —O-alkyl; (e) —OCF (f) —CN; (g) —NH (h) —C(O) (i) —C(O)NR (j) —(C (k) —NR (l) —NR (m) —NR (n) —NR (o) alkyl, or Y is selected from the group consisting of: (H) R (I) Each R (J) Each R (K) Each R (L) R wherein the aryl moiety in said substituted groups (2), (13), (14) and (16) of said R (M) (1) m is 0 to 3, and if m is greater than 1, m moieties can be the same or different from one another; such that m+n+o is 1, 2, 3 or 4, (N) p is 0 to 4, and if greater than 1, p moieties can be the same or different from one another; (O) r is 0 to 4, and if greater than 1, r moieties can be the same or different from one another; (P) s is 0 to 3, and if greater than 1, s moieties can be the same or different from one another; and (Q) Z is selected from the group consisting of: wherein said substituted heterocycloalkyl moiety of substituents (2), (14), (16), (24), (26) and (27) of group Z, and said substituted cycloalkyl moiety of substituents (7), (9), (20) and (22) of group Z, and said substituted aryl moiety of substituent (11) of group Z, and said substituted heteroaryl moiety of substituent (18) of group Z, are substituted with 1 to 3 groups independently selected from the group consisting of: