Patent ID: 6949550
Filing Date: 2005-09-27
Classification: A61P,C07D

Abstract:
1. A compound of formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein; M is pyrazole; ring M is substituted with 0-3 R ring P is absent and P one of P G is a group of formula IIa or IIb: ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O) ring D is substituted with 0-2 R and there are 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1 R and with a 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O) R is selected from H, C alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; A is phenyl substituted with 0-2 R B is imidazolyl substituted with 1 R G Z is selected from C(O)NH and C(O)CH R alternatively, when two R R R R alternatively, R R R R R R R 3a , at each occurrence, is selected from H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , C(CH 3 ) 3 , benzyl, and phenyl; alternatively, R R R R R R R alternatively, when R R R alternatively, R R R R R R R R alternatively, R R n, at each occurrence, is selected from 0, 1, 2, and 3; p, at each occurrence, is selected from 0, 1, and 2; r, at each occurrence, is selected from 0, 1, 2, 3,.4, 5, and 6; t, at each occurrence, is selected from 0, 1, 2, and 3; v, at each occurrence, is selected from 1, 2, 3, 4, 5, and 6.