Patent ID: 6777224
Filing Date: 2004-08-17
Classification: C12P,Y10S

Abstract:
A method for producing an optically active mandelic acid derivative, which comprises the steps of:(a) reacting a culture or cell bodies of a microorganism, or processed products thereof that can steroselectively reduce a phenylglyoxylic acid derivative of the formula (I) with said phenylglyoxylic acid derivative of the formula (I): wherein: X is hydrogen, alkali metal, or alkaline earth metal; R indicates one or more substituents at ortho, meta, or para position, wherein the substituent is halogen, hydroxyl group, alkyl group having 1 to 3 carbon atoms, alkoxy group, thioalkyl group, amino group, nitro group, mercapto group, phenyl group, or phenoxy group;(b) stereo-specifically reducing said phenylglyoxylic acid derivative with said microorganism culture, cell bodies or processed products to yield an optically active mandelic acid derivative of the formula (II): wherein: X and R is defined for formula (I); and(c) recovering said optically active mandelic acid derivative.