Patent ID: 6624178
Filing Date: 2003-09-23
Classification: A61K,A61P,C07D

Abstract:
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: whereinR1 is â€”R4-R5 or R11, R11 is selected from the group consisting of NHNHâ€”(2-pyridyl), â€”NHNHCONHPh, â€”NHNHCOPh, structure R4 is selected from the group consisting of â€”N(R7)R6Oâ€”, â€”N(R7)R6N(R7), â€”OR6O, and â€”OR6N(R7)â€”, where R6 is alkyl having 2 to 8 carbon atoms; R5 is selected from the group consisting of alkyl, aryl containing up to two conjugated or fused ring systems including heteroaryl, â€”COR7, â€”SO2R7, â€”C(S)NHR7, â€”C(NH)NHR7, â€”COR10, where R7 is selected from the group consisting of H, alkyl and aryl containing up to two conjugated or fused ring systems including heteroaryl, provided R7 might be different for R1 and R3 in the same compound; R2 is selected from the group consisting of F, Cl, Br, I, OR7, NO2, alkyl, aryl containing up to two conjugated or fused ring systems including heteroaryl, formyl, acyl, C(O)NR7R10, C(O)OR7, NR7R10, N&boxH;C(R7)(R10), SR7, SO2NH2, SO2 alkyl and SO2 aryl; m is 0, 1 or 2;R3 is selected from the group consisting of R7, OR7, N(R7) (R10), N&boxH;C(R7) (R10), N(R7) N(R7) (R10), N(R7) N&boxH;C(R7) (R10) and CH(R7)C(O)R8 where R8 is selected from the group consisting of R7, OR7 and NR7R10; R10 is selected from the group consisting of H, alkyl and aryl containing up to two conjugated or fused ring systems including heteroaryl and in each case optionally different from substituent R7, provided R10 might be different for R1 and R3 in the same compound; X is selected from the group consisting of a halide ion, acetate ion, perchlorate ion, sulfonate ion, oxalate ion. citrate ion, tosylate ion, maleate ion, mesylate ion, carbonate ion, sulfite ion, phosphoric hydrogen ion, phosphonate ion, phosphate ion, BF4- and PF6-; with proviso that, (i) when two alkyl groups are present on the same carbon or nitrogen, they are optionally linked together to form a cyclic structure and (ii) the nitrogen of heteroaryl ring of R10, when present, is optionally quaternized.