Patent ID: 6338810
Filing Date: 2002-01-15
Classification: A61F,A61K,A61L,C04B

Abstract:
Process for manufacturing an apatite ceramic, including the following steps:a) preparing a homogeneous mixture of powders including at least two calcium phosphates chosen from: Ca(H2PO4)2, Ca(H2PO4)2.H2O, Ca(HPO4).2H2O, Ca3(PO4)2 of the &agr; and &bgr; variety, and Ca4(PO4)2O, in quantities such that the mixture corresponds to a stoichiometric hydroxyapatite of formula: Ca10(PO4)6(OH)2â€ƒâ€ƒ(II); or a non-stoichiometric hydroxyapatite of formula: Ca10âˆ’xVx(PO4)6âˆ’y(HPO4)y(OH)2+yâˆ’2xâ€ƒâ€ƒ(III) â€ƒin which V represents a flaw and in which x and y are such that x<1, y<1, and y&lE;x, having a Ca/P atomic ratio less than 1.667; b) compacting the mixture of powders obtained in step a) at room temperature, under a pressure of 100 to 500 MPa, to yield a compacted piece; and c) subjecting the compacted piece to hydrothermal treatment in a sealed chamber containing an aqueous medium, at a temperature of 100 to 500Â° C., for a period of at least 8 hours.