Patent ID: 6936712
Filing Date: 2005-08-30
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula I, wherein R R R R R R R R D represents a direct bond or C X represents O or S; R R R R R R R E represents, at each occurrence when used herein, a direct bond or C p represents 1 or 2; Het R A represents a direct bond, —J—, —J—N(R B represents —Z—, —Z—N(R —N(R —C(O) is attached to the carbon atom bearing R J represents C Z represents a direct bond or C n represents 0, 1 or 2; R G represents CH or N; R —C(O)N(R R R R R wherein each aryl and aryloxy group, unless otherwise specified, is optionally substituted; provided that (a) when A represents —J—N(R (b) when R or a pharmaceutically acceptable derivative thereof; which process comprises the dehydrative cyclisation of a compound of formula II, wherein A, B, G, R