Patent ID: 6703199
Filing Date: 2004-03-09
Classification: C07K,C12N,C40B,G01N

Abstract:
A fibronectin-peptide display library comprising fibronectin type III (Fn3) polypeptide monobodies, each Fn3 polypeptide monobody comprising at least two Fn3 &bgr;-strand domain sequences with a loop region sequence linked between each Fn3 &bgr;-strand domain sequence,wherein at least one monobody loop region sequence varies as compared to the wild-tyne (SEQ ID NO:110, FIG. 2) loop region sequence by deletion of two to twelve amino acids in the loop region sequence, insertion of at least two to 25 amino acids, or replacement of at least two amino acids in the loop region sequence, and wherein the polypeptide monobody loop region comprises a peptide with at least two amino acids that binds to a specific binding partner (SBP) to form a polypeptide:SBP complex.