Patent ID: 7820619
Filing Date: 2010-10-26
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antimicrobial peptide, consisting of an amino acid sequence of 13 to 74 amino acids with a 7 amino acid core sequence: aa1-aa2-aa3-aa4-aa5-aa6-aa7, wherein aa1 is the amino-terminus of the core sequence and is selected from the group consisting of alanine, lysine and glycine; aa2 is selected from the group consisting of leucine and arginine; aa3 is tyrosine; aa4 and aa5 are selected from the group consisting of lysine, arginine, and histidine; and one of aa6 and aa7 is selected from the group consisting of phenylalanine, tryptophan and tyrosine, such that when aa6 is phenylalanine aa7 is selected from the group consisting of lysine, arginine and histidine, when aa6 is tryptophan aa7 is lysine, and when aa7 is phenylalanine aa6 is leucine; and a modified antimicrobial peptide with the amino acids in said 7 amino acid core sequence modified and retaining antimicrobial activity, wherein said modified amino acids are selected from the group consisting of N-epsilon-monomethyl-lysine, beta branched amino acids, N-methyl amino acids, alpha, beta-dehydro amino acids, and fluorinated amino acids.