Patent ID: 8673316
Filing Date: 2014-03-18
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A tetravalent Dengue virus immunogenic composition comprising: a first nucleic acid molecule comprising an attenuated Dengue-2 virus; a second nucleic acid molecule comprising a chimeric Dengue-2 virus/Dengue-1 virus comprising a nucleic acid sequence encoding at least one non-structural protein from an attenuated Dengue-2 virus strain and a nucleic acid sequence encoding at least one structural protein from a Dengue-1 virus; a third nucleic acid molecule comprising a chimeric Dengue-2 virus/Dengue-3 virus comprising a nucleic acid sequence encoding at least one non-structural protein from an attenuated Dengue-2 virus and at least one structural protein from a Dengue-3 virus; and a fourth nucleic acid molecule comprising a chimeric Dengue-2 virus/Dengue-4 virus comprising a nucleic acid sequence encoding at least one non-structural protein from an attenuated Dengue-2 virus strain and at least one structural protein from a Dengue-4 virus.