Patent ID: 6660724
Filing Date: 2003-12-09
Classification: A61K,A61P,C07F,Y02P

Abstract:
A process for preparing a compound of formula (Ia): wherein X1 is H, C(1-3)alkyl, hydroxy or C(1-4)alkoxy; X2 is C(1-3)alkyl or C(1-4)alkoxy; X3 is H or C(1-4)alkyl; R1, R2, which may be identical or different, are H or C(1-3)alkyl; B is CH2CH2, CH&boxH;CH, or CH2; n is zero or 1; Z is H; m is an integer from 1 to 5; X4 is H, or C(1-8)alkyl, C(1-8)alkoxy or halo; and the pyridyl ring is attached by the ring carbon &agr;- or &bgr;- to the nitrogen (2- or 3-pyridyl); which process comprises (a) treating an amine of formula (VII) in which B, R1, R2, X1, X2, X3 and n are as hereinbefore defined; with an aldehyde of formula (IX): in which m and X4 are as hereinbefore defined; under reductive amination conditions.