Patent ID: 6511989
Filing Date: 2003-01-28
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula (I), whereinR(1) is a) (C1-C4)-alkyl; or b) â€”Oâ€”(C1-C4)-alkyl, which is unsubstituted or is substituted by 1, 2, or 3 fluorine atoms; or c) â€”Oâ€”(C1-C4)-alkyl which is substituted by a substituent chosen from nitro, ((C1-C4)-alkyl)carbonylamino, (C1-C4)-alkylamino, di((C1-C4)-alkyl)amino, hydroxycarbonyl, ((C1-C4)-alkoxy)carbonyl, piperidin-1-yl, morpholin-4-yl, tetrahydrofuranyl, tetrahydropyranyl, phenyl and phenoxy; wherein the phenyl group and the phenoxy group are unsubstituted or are substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl; or d) â€”Oâ€”(C1-C4)-alkyl-E(1)-(C1-C4)-alkyl-D(1), in which D(1) is hydrogen or â€”E(2)-(C1-C4)-alkyl-D(2), in which D(2) is hydrogen or â€”E(3)-(C1-C4)-alkyl, wherein E(1), E(2) and E(3), which are independent of one another and can be identical or different, are chosen from O, S, and NH; or e) â€”Oâ€”(C1-C4)-alkyl-Oâ€”(C1-C4)-alkyl, which is substituted in the terminal alkoxy group by 1, 2, or 3 fluorine atoms; or f) â€”Oâ€”(C2-C4)-alkenyl; or g) â€”O-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl; or h) halogen; or i) phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, â€”S(O)mâ€”(C1-C4)-alkyl, phenyl, amino, hydroxyl, nitro, trifluoromethyl, cyano, hydroxycarbonyl, carbamoyl, ((C1-C4)-alkoxy)carbonyl, and formyl; or j) (C2-C5)-alkenyl, which is unsubstituted or is substituted by a substituent chosen from phenyl, cyano, hydroxycarbonyl, and ((C1-C4)-alkoxy)carbonyl; or k) (C2-C5)-alkynyl, which is unsubstituted or is substituted by a substituent chosen from phenyl and (C1-C4)-alkoxy; or l) 5-membered or 6-membered monocyclic heteroaryl having one or two identical or different ring heteroatoms chosen from oxygen, sulfur, and nitrogen; or m) â€”S(O)m-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy and trifluoromethyl; R(2) is hydrogen, (C1-C6)-alkyl, or (C3-C7)-cycloalkyl, but is not hydrogen if Z is oxygen; the residues R(3), which are all independent of one another and can be identical or different, are hydrogen or (C1-C3)-alkyl; A is chosen from: â€ƒwherein the free bond via which the residue A is bonded to the amino group in the formula (I) is represented by the symbol ; X is oxygen or sulfur; Y is â€”(CR(3)2)nâ€”; Z is NH or oxygen; m is 0, 1 or 2; n is 1, 2, 3 or 4; or a stereoisomeric form of a compound of formula (I), or a mixture of at least two stereoisomeric forms of a compound of formula (I), or a physiologically tolerable salt of a compound of formula (I).