Patent ID: 8124337
Filing Date: 2012-02-28
Classification: C12Q,G01N

Abstract:
1. A method for assessing the Hereditary cataract (HC) status of a Staffordshire bull terrier or French bulldog, or the juvenile HC status of a Boston terrier, comprising: a) providing a sample of nucleic acid comprising the HSF4 genomic sequence from the Staffordshire bull terrier, French bulldog, or Boston terrier; b) assaying the nucleic acid sample for an HSF4 marker wherein the HSF4 marker is a C insertion mutation at position 3034-3045 of SEQ ID NO: 10, wherein the C insertion mutation results in 11Cs; c) detecting the homozygous presence of the insertion mutation; and d) identifying the Staffordshire bull terrier or French bulldog as affected with HC or the Boston terrier as affected with juvenile HC.