Patent ID: 6703212
Filing Date: 2004-03-09
Classification: A61P,C07D,Y10S

Abstract:
A method for diagnosing Alzheimer's disease, comprising measuring fluorescence emission spectra of a blood sample from a patient, said blood sample having been incubated with (i) a fluorescent probe recognizing a catalytic site of protein kinase A (PKA), or (ii) a fluorescent probe recognizing a catalytic site of protein kinase C (PKC), or (iii) two fluorescent probes respectively recognizing a catalytic site and a regulator domain of PKA, or (iv) two fluorescent probes respectively recognizing a catalytic site and a regulator domain of PKC, said fluorescence emission spectra being measured in the presence and absence of an inhibitor or activator of said PKA or PKC; wherein a variation in said fluorescence emission spectra relative to fluorescence emission spectra obtained from healthy subjects is a diagnostic indicator for Alzheimer's disease.