Patent ID: 8268811
Filing Date: 2012-09-18
Classification: A61P,C07D

Abstract:
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: X X X provided that at least one of X Ht is thiazole or pyrazole, wherein each ring is optionally and independently substituted with R Q is —O—, —NR′—, —S—, —C(═O)—, or —C(R′) R R R Ring D is a 5-7 membered monocyclic aryl or heteroaryl ring, wherein said heteroaryl has 1-4 ring heteroatoms selected from O, N, and S; Ring D can optionally be fused with Ring D′; Ring D′ is a 5-8 aromatic, partially saturated, or fully unsaturated ring containing 0-4 ring heteroatoms selected from nitrogen, oxygen or sulfur; Ring D and Ring D′ are each independently and optionally substituted with 0-4 occurrences of oxo or —W—R each T is independently a C R R each Z and W is independently a bond or a C each V is selected from —O—, —C(═O)—, —S(O)—, —S(O) each R each R is hydrogen, a C each R each R each R each R each R each J is independently R, -halo, —OR, oxo, —C(═O)R, —CO 2 J groups, on the same atom or on different atoms, together with the atom(s) to which they are bound, form a 3-8 membered saturated, partially saturated, or unsaturated ring having 0-2 heteroatoms selected from O, N, or S; wherein 1-4 hydrogen atoms on the ring formed by the 2 J groups is optionally replaced with halo, C each R′ is independently hydrogen or a C each R″ is independently H or C