Patent ID: 6284896
Filing Date: 2001-09-04
Classification: A61P,C07D

Abstract:
A compound represented by formula I"": ##STR13##whereinR.sub.1 is a hydrogen, chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano, nitro or carboxamido group;R.sub.2 is C.sub.1 -C.sub.3 alkyl or an allyl group;R.sub.3 and R.sub.4 are independently a hydrogen atom, a linear or branched C.sub.1 -C.sub.5 alkyl group, a linear or branched C.sub.3 -C.sub.5 alkenyl group, a C.sub.5 -C.sub.6 cycloalkyl C.sub.1 -C.sub.3 alkyl group, a phenyl-C.sub.1 -C.sub.3 alkyl, a phenyl-C.sub.3 -C.sub.5 alkenyl or phenyl group:which groups are optionally substituted by C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, trifluoromethyl, hydroxy or amino group; or a group of the formula ##STR14##whereinR.sub.6 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and R.sub.7 is a phenyl group or a substituted phenyl group as described above;between positions 9-10 represents a single or a double bond;R.sub.5 is a hydrogen, bromine, fluorine or iodine atom or a methoxy, cyano, carboxamido, nitro, methylthio or trifluoromethyl or a group of the formula NR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are independently a hydrogen atom, or a C.sub.1-3 alkyl, acetyl, methanesulphonyl or trifluoroacetyl group; andR represents a hydrogen atom or a C.sub.1-5 linear or branched alkyl, methanesulphonyl or acetyl group or a group of the formula CONR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are as defined above;or a pharmaceutically acceptable salt thereof.