Patent ID: 8463552
Filing Date: 2013-06-11
Classification: G01R,G16C,G16H,Y10T

Abstract:
1. A method for determining quantitative pharmacodynamic parameters for a pharmacologically active agent in a biological organism, the method comprising: a) administering to a biological organism a plurality of doses of the pharmacologically active agent, over a sufficiently brief time interval, wherein the response of the biological organism to the pharmacologically active agent does not return to baseline between doses; b) collecting biological imaging data comprising the biological organism's response to the plurality of doses of the pharmacologically active agent administered in a), in a single imaging session, over the sufficiently brief time interval; and c) fitting predetermined pharmacokinetic-pharmacodynamic models to said imaging data to determine the quantitative pharmacodynamic parameters for said pharmacologically active agent comprising: i) setting up fit parameters and choosing a fit method; ii) computing best-fit parameters and their goodness of fit to the biological data using the selected fit method; iii) computing the statistical significance of the best-fit parameters; and iv) generating an output.