Patent ID: 6207199
Filing Date: 2001-03-27
Classification: A61K

Abstract:
A process for producing a particulate support matrix for use in forming a pharmaceutical dosage form, comprising:providing an aqueous composition comprising:an aqueous medium,a support agent comprising an amount of a first polypeptide component having a predetermined net charge, an amount of a second polypeptide component having a predetermined net charge of the same sign as the first polypeptide component and a bulking agent and wherein the first polypeptide component and the second polypeptide component together comprise about 2% to 35% by weight of the particulate support matrix and wherein the bulking agent comprises about 45% to 97% by weight of the particulate support matrix, and wherein the second polypeptide component has a solubility in aqueous solution greater than that of the first polypeptide component, anda volatilizing agent; andintroducing the aqueous composition as droplets into a drying chamber heated to a temperature sufficient to evaporate substantially all of the aqueous medium and volatilizing agent from the droplets leaving the support agent in a dried particulate form comprising the particulate support matrix and wherein the particulate support matrix is substantially completely disintegrable within less than about 20 seconds when introduced into an aqueous environment.