Patent ID: 8932576
Filing Date: 2015-01-13
Classification: A61P,C12N

Abstract:
1. A method of treating intestinal bacterial or viral infection comprising administering to a subject in need thereof a therapeutically effective amount of an alga obtained from an algal cell transformed by replacing an endogenous chloroplast gene via integration of a chimeric construct having a heterologous coding sequence, a promoter sequence, at least one UTR, and nucleotide sequences of chloroplast genomic DNA flanking the heterologous coding sequence, the promoter sequence and the at least one UTR, the nucleotide sequences operable to allow homologous recombination of the construct with the chloroplast genome and replacement of the endogenous chloroplast gene, wherein the endogenous chloroplast gene is re-inserted at a silent distal site, wherein the promoter is cognate or non-cognate to the endogenous chloroplast gene, and wherein the heterologous coding sequence encodes a protein useful for treating the intestinal bacterial or viral infection.