Patent ID: 9109011
Filing Date: 2015-08-18
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A composition comprising: a dendritic cell (DC)-specific antibody or fragment thereof comprising a light chain sequence selected from the group consisting of SEQ ID NO: 24, 25, 26, 27 and 28 and a heavy chain sequence selected from the group consisting of SEQ ID NO: 29 and 30, to which one or more engineered Gag antigens are attached to form an antibody-antigen fusion protein wherein the engineered Gag antigens are less susceptible to proteolytic degradation by eliminating one or more proteolytic sites; and a Nef antigen that is attached to the engineered Gag antigen wherein the composition is able to elicit a human immunodeficiency virus (HIV)-specific T cell immune response to Gag and Nef.