Patent ID: 6677345
Filing Date: 2004-01-13
Classification: A61K,A61P,C07D,C07H

Abstract:
A method for the treatment of a tumour or other cell proliferation disorder in a mammal which comprises administering to a mammal in need of such treatment an antitumour or cyclin dependent kinase-inhibiting amount of a pyrimidine compound having the structural formula I or a pharmaceutically acceptable salt and/or prodrug form thereof whereinx is O, S or CHRx where Rx is H or C1-4 alkyl; D is H or NZ1Z2 where Z1 and Z2 are each independently H, C1-4 alkyl, C1-4 hydroxyalkyl, optionally substituted aryl or optionally-substituted aralkyl; A is selected from H, C1-4 alkyl, C1-4 alkoxy, hydroxy, CH2(CH2)nOH (n=1-4), and NRa1Ra2 where Ra1 and Ra2 are each independently H or C1-4 alkyl; Y is an optionally substituted 5- or 6-membered cycloalkane or cycloalkene ring having one or two double bonds; Dâ€² is H or NZ3Z4 where Z3 and Z4 are each independently H, C1-4 alkyl, C1-4 hydroxyalkyl, optionally substituted aryl or optionally-substituted aralkyl; E is selected from H, NO, NO2, N&boxH;Nâ€”Ar where Ar is an optionally substituted aryl or optionally substituted aralkyl, NRe1Re2 or NRe1NR2Re3 (Re1, Re2 and Re3 each being independently H, C1-4 alkyl, C1-4 hydroxyalkyl, an optionally substituted aryl or an optionally substituted aralkyl), C(Re)&boxH;U (Re being hydrogen, C1-4 alkyl or substituted alkyl, or an unsubstituted or substituted aryl or aralkyl, and U being selected from O, NReâ€², NOReâ€² and Nâ€”NReâ€²Reâ€³ where Reâ€² and Reâ€³ are each independently H, C1-4 alkyl or CONH2), T, CH2T, CHT2 and CT3, where T is a halide I; Br; Cl or F.