Patent ID: 8586721
Filing Date: 2013-11-19
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant nucleic acid comprising a sequence that encodes (a) a heavy chain variable region (VH) complementary determining region one (CDR1) comprising the amino acid sequence shown in SEQ ID NO: 30, 49 or 50, a VH CDR2 comprising the amino acid sequence shown in SEQ ID NO: 32 or 51, and a VH CDR3 comprising the amino acid sequence shown in SEQ ID NO: 34 or 52; and (b) a light chain variable region (VL) CDR1 comprising the amino acid sequence shown in SEQ ID NO: 22, a VL CDR2 comprising the amino acid sequence shown in SEQ ID NO: 24, and a VL CDR3 comprising the amino acid sequence shown in SEQ ID NO: 26; wherein an antibody or immunologically functional fragment thereof encoded by the nucleic acid specifically binds Dickkopf 1 (Dkk-1) polypeptide.