Patent ID: 7642045
Filing Date: 2010-01-05
Classification: C07K,C12N

Abstract:
1. An isolated antibody that (a) binds to the cytosolic phosphoprotein that (i) is induced during differentiation of BM cells to dendritic cells and (ii) is induced in bone marrow (BM) cells by incubation of the cells with antisera raised against a dendritic cell lysate following adsorption of the antisera with splenocytes, liver cells, dendritic cells, and myeloma cells, wherein the dendritic cells used to prepare the lysate are DC-enriched (over 95%) and also comprise BM cells at intermediate stages of differentiation and (iii) is not induced by said antisera following further absorption of the antisera with fresh or formalin-fixed BM cells and (b) binds to the peptide of SEQ ID NO: 4.