Patent ID: 6627228
Filing Date: 2003-09-30
Classification: A61K,A61P,C08F,C08G,C08L

Abstract:
A polymeric delivery agent comprising a polymer conjugated to a modified amino acid or derivative thereof via a linkage group selected from the group consisting of â€”NHC(O)NHâ€”, â€”C(O)NHâ€”, â€”NHC(O)â€”, â€”OOCâ€”, â€”COOâ€”, â€”NHC(O)Oâ€”, â€”OC(O)NHâ€”, â€”CH2NHâ€”, â€”NHCH2â€”, â€”CH2NHC(O)Oâ€”, â€”OC(O)NH2â€”, CH2NHCOCH2Oâ€”, â€”OCH2C(O)NHCH2â€”, â€”NHC(O)CH2Oâ€”, â€”OCH2C(O)NHâ€”, â€”NHâ€”, â€”Oâ€”, and carbon-carbon bond, with the proviso that the polymeric delivery agent is not a polypeptide or polyamino acid, wherein the modified amino acids are acylated or sulfonated amino acids, ketones or aldehydes of acylated or sulfonated amino acids, salts thereof, or polyamino acids or polypeptides of any of the foregoing, and the polymer is selected from the group consisting of polyethylene; polyacrylates; polymethacrylates; poly(oxyethylene); poly(propylene); polypropylene glycol; polyethylene glycol (PEG); PEG-maleic anhydride copolymers; and derivatives and combinations thereof.