Patent ID: 7960175
Filing Date: 2011-06-14
Classification: A61P,C07K

Abstract:
1. A NOD/SCID/IL2rg-null mouse, which as a newborn had transplanted therein human-derived hematopoietic stem or precursor cells, and which is able to generate immunocompetent cells derived from said human-derived hematopoietic stem or precursor cells and physiologically active substances derived from said immunocompetent cells, and wherein the immunocompetent cells comprise B cells, T cells and dendritic cells, wherein after the mouse has matured for three months: (a) bone marrow tissue extracted from the matured mouse has a ratio of human-derived hematopoietic cells to recipient-derived hematopoietic cells of between 58.8:100 and 90:100, (b) spleen tissue extracted from the matured mouse has a ratio of human-derived antibody-generating cells to recipient-derived antibody-generating cells of between 47.1:100 and 80:100; or (c) peripheral blood extracted from the matured mouse has a ratio of human-derived antibody-generating cells to recipient-derived antibody-generating cells of between 50.1:100 and 80:100.