Patent ID: 9095511
Filing Date: 2015-08-04
Classification: A61K,A61P

Abstract:
1. A method for stabilizing a fluid oil-based suspension comprising an active pharmaceutical ingredient and a hydrophobic silica against sedimentation, the method comprising contacting the hydrophobic silica with an amphiphilic substance comprising a nonionic polyoxyethylated compound in the fluid oil-based suspension, wherein the polyoxyethylated compound is selected from the group consisting of poloxamers, polyoxyethylene fatty acid glycerides, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acids, and polyoxyethylene fatty alcohols, and wherein the stabilized fluid oil-based suspension, following contact with the amphiphilic substance, comprises the amphiphilic substance in a proportion of 0.001-0.15% by weight.