Patent ID: 8188115
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. A method for treating a central nervous disorder comprising administering to a patient in need thereof a therapeutically effective amount of the compound of formula (I) wherein W is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR 8 , —C(O)OR 8 , —C(O)NR 8 R 9 —C═NR 8 , —CN, —OR 8 , —OC(O)R 8 , —S(O) t —R 8 , —NR 8 R 9 , —NR 8 C(O)R 9 , —NO2, —N═CR 8 R 9 or halogen, wherein t is 1, 2 or 3; R 8 and R 9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen; n is 4, 5 or 6; or a pharmaceutically acceptable salt or isomer thereof, wherein the central nervous disorder is sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiety, psychosis, schizophrenia, pain, cognition and memory disorders, neuronal degeneration resulting from ischemic events, cardiovascular diseases, irritable bowel syndrome, inflammatory bowel disease, spastic colon or urinary incontinence.