Patent ID: 6113527
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
Compounds of the general formula I ##STR82## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, which is unsubstituted or substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, which is unsubstituted or substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;R.sup.2 is .dbd.O or hydrogen,R.sup.3 is hydrogen, isoindolyl-1,3-dione, lower alkoxy, lower alkyl, amino, benzyloxy, --CH.sub.2 OR.sup.5 or --CH.sub.2 N(R.sup.5).sub.2 ;R.sup.4 is hydrogen or --CH.sub.2 OR.sup.5 ;R.sup.5 is hydrogen or lower alkyl; ##STR83## is cyclohexyl or phenyl, which is unsubstituted or substituted by lower alkyl, halogen or alkoxy;racemic mixtures and their corresponding enantiomers and pharmaceutically acceptable acid addition salts thereof.