Patent ID: 6828301
Filing Date: 2004-12-07
Classification: A61K,A61P

Abstract:
A pharmaceutical composition comprising:(a) a compound of formula (I): wherein: designates an optional bond forming a double bond between positions 13 and 14; R1 is H, halo, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-6 cycloalkoxy, hydroxy, or N(R5)2, wherein each R5 is independently H, C1-6 alkyl or C3-6 cycloalkyl; R2 is H, halo, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, C1-6 thioalkyl, C1-6 alkoxy, C3-6 cycloalkoxy, C2-7 alkoxyalkyl, C6 or 10 aryl or Het, wherein Het is a five-, six-, or seven-membered saturated or unsaturated heterocycle containing from one to four ring heteroatoms selected from nitrogen, oxygen and sulfur; said cycloalkyl, aryl or Het being optionally substituted with R6, wherein R6 is H, halo, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C3-6 cycloalkoxy, NO2, N(R7)2, NHâ€”C(O)â€”R7; or NHâ€”C(O)â€”NHâ€”R7, wherein each R7 is independently: H, C1-6 alkyl or C3-6 cycloalkyl; or R6 is NHâ€”C(O)â€”OR8 wherein R8 is C1-6 alkyl or C3-6 cycloalkyl; R3 is R9Oâ€” or R9NHâ€”, wherein R9 is C1-6alkyl or C3-6cycloalkyl; R4 is H or from one to three substituents on any available carbon atom at positions 8, 9, 10, 11, 12, 13 or 14, said substituent independently selected from the group consisting of: C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, hydroxy, halo, amino, oxo, thio or C1-6 thioalkyl; or a tautomer thereof;(b) about 0.1 to 10% by weight of a pharmaceutically acceptable amine or a mixture of pharmaceutically acceptable amines; and (c) one or more pharmaceutically acceptable oils; (d) optionally one or more pharmaceutically acceptable hydrophilic solvents; (e) optionally one or more pharmaceutically acceptable polymers; and (f) optionally one or more pharmaceutically acceptable surfactants.