Patent ID: 9023370
Filing Date: 2015-05-05
Classification: A61K,A61P,B82Y

Abstract:
1. A conjugate of the formula (I) having colloidal stability in a medium wherein NP is a gold, silver or platinum nanoparticle; L is a linker of formula (II) or a stereoisomer thereof, which is attached to the nanoparticle NP through the sulfur atom; or L is a linker of formula (III) or a stereoisomer thereof, which is attached to the nanoparticle NP through the two sulfur atoms wherein: X and Y independently represent a (C n and s independently represent a value from 0 to 1; p represents a value from 1 to 2; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt, and is attached to the linker L through the single bonded oxygen atom of the carboxyl groups with the condition that: when in the linker of formula (II) or formula (III), n=1 or s=1; the platinum (II) biradical is attached to one molecule of linker of formula (II) or formula (III), thereby forming two COO—Pt bonds with the same linker molecule; and when in the linker of formula (II) or formula (III), n=0 or s=0; the platinum (II) biradical is attached to two independent linker molecules of formula (II) or formula (III), thereby forming a COO—Pt bond with each of these two linker molecules; and being at least 45% of the linkers L of formula (II) or formula (III) in the form of free carboxyl groups.