Patent ID: 6096768
Filing Date: 2000-08-01
Classification: C07C,C07D

Abstract:
A method for treating an inflammatory disease or an autoimmune disease capable of being modulated by inhibiting TNF, said method comprising administering to a patient suffering from said disease an effective amount of a compound of formula I ##STR36## wherein R.sup.1 is optionally substituted lower alkyl;R.sup.2 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted or oxidized cyclothioalkyl or optionally substituted or oxidized cyclothioalkenyl;R.sup.3 is optionally substituted aryl or optionally substituted pyridyl;Z, Z.sup.1 and Z.sup.2 are independently oxygen or sulfur; andZ.sup.3 is --CZNH--,or an N-oxide thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof.