Patent ID: 7591994
Filing Date: 2009-09-22
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A conjugate of a camptothecin drug and a targeting moiety, wherein the conjugate has a structural formulae selected from the group consisting of MAb-CL1-SN-38, MAb-CL2-SN-38, MAb-CL3-SN-38, MAb-CL4-SN-38, MAb-CL5-SN-38 and having a structure selected from: wherein said MAb is selected from the group consisting of a murine, chimeric, primatized, humanized, or human monoclonal antibody, and said antibody is in intact, fragment (Fab, Fab′, F(ab)2, F(ab′)2), or sub-fragment (single-chain construct) form.