Patent ID: 7858070
Filing Date: 2010-12-28
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of delivering a diagnostic or therapeutic agent comprising: a) obtaining a stably tethered structure comprising at least one diagnostic or therapeutic agent, wherein the stably tethered structure comprises (i) an IgG antibody that binds to tumor-associated antigen wherein the antibody is attached to two AD anchor domain) moieties and (ii) four copies of a cytokine, each cytokine attached to a DDD (dimerization and docking domain) moiety, wherein the AD moiety has the peptide sequence from an anchoring domain of an AKAP (A-kinase anchoring protein) selected from the group consisting of AD1 (SEQ ID NO: 3) and AD2 (SEQ ID NO: 4) and the DDD moiety has the peptide sequence from a dimerization and docking domain of protein kinase A selected from the group consisting of DDD1 (SEQ ID NO: 1) and DDD2 (SEQ ID NO: 2); and b) administering the stably tethered structure to a subject.