Patent ID: 6096752
Filing Date: 2000-08-01
Classification: B01J,C07D,C08F

Abstract:
A process of preparing a tertiary amine compound of the formula (V) ##STR15## where R is alkyl and R.sup.6 and R.sup.7 are alkyl groups which are optionally substituted or where R.sup.6 and R.sup.7 form a ring or ring system, wherein said method comprises the steps ofa) reacting a compound of the formula (I) ##STR16## wherein Y is a solid or soluble support, where Y may include a residue of a functional group having been attached to said support, said functional group having been hydroxy, amino, thio, epoxy or halogen,R.sup.1 is aryl, heteroaryl, alkyl chain or a ring or ring system, which may include a heteroatom, or R.sup.1 is nothing, and R.sup.2 is vinyl;CH.sub.2 CH.sub.2 X, where X is halogen; or R.sup.3 C.dbd.CHR.sup.4 or R.sup.3 CH--CH.sub.2 R.sup.4 X, where R.sup.3 and R.sup.4 are the same or different and are alkyl, acyl, carbonyl, cyano or nitro groups and X is halogen, with a secondary amine (II) ##STR17## wherein R.sup.8 and R.sup.9 are the same as or different from the groups R.sup.6 and R.sup.7 defined above and are alkyl groups, which are optionally substituted, or form a ring or ring system, to give a compound (III) ##STR18## wherein R.sup.10 is CH.sub.2 CH.sub.2 or R.sup.3 CH--CHR.sup.4, where R.sup.3 and R.sup.4 are as defined above,b) quaternising the compound (III) with an alkyl halide RX where R is alkyl and X is halide or an ester of an alkyl sulfonic acid, to give a quaternary ammonium ion (IV) ##STR19## c) cleaving the quaternary ammonium ion (IV) to give the tertiary amine (V),and, in case R.sup.8 and R.sup.9 are different from R.sup.6 and R.sup.7, carrying out the reactions interchanging these groups as separate steps between steps a) and b) above.