Patent ID: 7396929
Filing Date: 2008-07-08
Classification: C07D

Abstract:
1. A process of making a 3-amino-4-substituted pyrazole derivative of the formula: in which R wherein one or more of the aryl and/or one or more of the heteroaryl in the above-noted definitions for R R R R R R R R m is 0 to 4 which comprises: (a) reacting a compound of formula II with a compound of formula III where R′ is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, alkylaryl, substituted alkylaryl, cycloalkyl, substituted cycloalkyl, heterocycyl or substituted heterocycyl, in the presence of LDA, LiHMDS, KHMDS, or NaHMDS and a solvent at a temperature between about −100° C. to about 0° C. to give a compound of formula IV and b) reacting a compound of formula IV with hydrazine and acetic acid in an alcoholic solvent at a temperature between about 50° C. to about 150° C. to give a compound of formula I.