Patent ID: 7824683
Filing Date: 2010-11-02
Classification: A61K,A61P,C07K

Abstract:
1. A method for activating or augmenting an immune response of a subject having CD40-positive cells associated with a cancer comprising: administering to the subject an amount of an unconjugated antibody, which unconjugated antibody (i) competes for binding to CD40 with monoclonal antibody S2C6 as secreted by the hybridoma deposited with the ATCC and assigned accession number PTA-110, (ii) increases the binding of CD40 ligand to CD40 by at least 45%, and (iii) is a chimeric or humanized form, or fragment thereof, of monoclonal antibody S2C6 as secreted by the hybridoma deposited with the ATCC and assigned accession number PTA-110, which amount is such that the immune response of the subject is activated or augmented.