Patent ID: 9211292
Filing Date: 2015-12-15
Classification: A61K,A61P

Abstract:
1. A method of treating a patient that prevents or reduces drug abuse and overdose events with drugs, said method comprising: oral administration of a first amount of a pharmaceutical composition comprising at least one drug bound to at least one ion exchange resin as a resinate, said ion exchange resins being selected from the group consisting of a cationic ion exchange resin and a anionic ion exchange resin, each said ion exchange resin being bound to at least one drug, wherein each bound drug, measured as the unbound state, is less than about 75 percent of its saturation concentration in its resinate leaving unused binding capacity in its ion exchange resin, said saturation concentration being defined as the larger of: (a) the weight of drug per weight of washed and dried resinate after at least three hours of stirred aqueous resination reaction in a slurry of the drug in de-ionized water at a temperature in the range of 59 to 61° C. with the initial weight of drug being at least fourfold that of the weight of ion exchange resin present; and (b) the weight of drug per weight of washed and dried resinate after at least three hours of stirred aqueous resination reaction in a slurry of the drug at a temperature in the range of 59 to 61° C. with the initial weight of drug being at least fourfold that of the weight of ion exchange resin present, and at a pH having a value within about ±1 unit of the pK said unused ion exchange binding capacity acting as an ion sink limiting the cumulative release of each bound drug to less than about twice the cumulative release from said first amount if immediately after the administration of said first amount of said pharmaceutical composition, a second equal amount of said pharmaceutical composition is ingested by said patient.