Patent ID: 6624290
Filing Date: 2003-09-23
Classification: A61K,C07K

Abstract:
An azapeptide compound represented by the formula: wherein:(a) n=3-7 (b) R1=a substituted or unsubstituted amino acid; (c) R2=substituted or unsubstituted alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted heteroalkyl; substituted or unsubstituted cycloalkyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; substituted or unsubstituted arylalkyl; substituted or unsubstituted alkoxycarbonyl, or substituted or unsubstituted aryloxycarbonyl; (d) R3=â€”Oâ€”CH(R4)â€”R5, â€”Oâ€”R5, or â€”Sâ€”R5, wherein R4 is selected from the group consisting of: H; halo; cyano; substituted or unsubstituted alkyl, and substituted or unsubstituted alkenyl; and wherein R5 is selected from the group consisting of unsubstituted or substituted alkyl, with the proviso that said substitution does not include fluorine as a substituent; substituted or unsubstituted alkenyl; substituted or unsubstituted haloalkyl; substituted or unsubstituted haloalkenyl; substituted or unsubstituted heteroalkyl; substituted or unsubstituted cycloalkyl; substituted or unsubstituted heteroaryl, and substituted or unsubstituted arylalkyl, with the proviso that when R2 is a substituted alkyl, R5 is not a substituted or unsubstituted arylalkyl, or a pharmaceutically acceptable salt thereof.