Patent ID: 7709444
Filing Date: 2010-05-04
Classification: A61K,A61P,Y02A

Abstract:
1. A stabilized freeze-dried formulation comprising (i) an echinocandin compound, or a pharmaceutically acceptable salt thereof; (ii) a pharmaceutically acceptable micelle-forming surfactant with an HLB value of 10-18; (iii) a bulking agent; and (iv) a stabilizing agent, wherein said micelle-forming surfactant is present in said freeze-dried formulation in an amount greater than 5% by weight, and at a weight ratio of echinocandin compound to surfactant from about 1:1.75 to about 1:25; wherein said micelle-forming surfactant is not a block copolymer of propylene oxide and ethylene oxide; wherein, upon freeze drying, said freeze-dried formulation is a well-formed cake suitable for reconstitution as a parenteral pharmaceutical formulation suitable for intramuscular, intravenous or subcutaneous administration; wherein: R is a group having the structure: wherein R R R R R pharmaceutically acceptable salts thereof; wherein said bulking agent is selected from the group consisting of mannitol, glycine, sucrose, trehalose, lactose, dextran, hydroxyethyl starch, ficoll and gelatin; and wherein said stabilizing agent is a carbohydrate.