Patent ID: 6500823
Filing Date: 2002-12-31
Classification: A61P,C07C,C07D

Abstract:
An unsaturated hydroximic acid derivative of the formula I: whereinR1 represents a C1-20 alkyl group, a phenyl group optionally substituted by 1-3 substituents selected from the group consisting of a C1-2 alkyl group, a C1-2 alkoxy group, a halo atom, an amino group, a (C1-4 alkyl)-amino group, a di(C1-4 alkyl)-amino group and a di(C1-4 alkanoyl)amino group, furthermore R1 represents a 5- or 6-membered, saturated or unsaturated heterocyclic group containing one or two nitrogen atom(s) or a sulfur atom as the heteroatom, and R2 stands for a hydrogen atom, or R1 forms together with R2 a C5-7 cycloalkyl group optionally condensed with a benzene ring, Y means a hydrogen atom, a hydroxy group, a C1-30 alkanoyloxy group or a C3-22 alkenoyloxy group, X is a halo atom, a hydroxy group or an amino group, R3 represents a C3-7 cycloalkyl group or a group of the formula â€”NR4R5, wherein R4 and R5 mean, independently, a hydrogen atom, a C1-5 alkyl group, a C1-5 alkanoyl group, or R4 and R5 form with the adjacent nitrogen atom a 5- or 6-membered, saturated or unsaturated heterocyclic group that may contain also an oxygen atom and can be condensed with a benzene ring, wherein the heterocyclic group and/or the benzene ring may be substituted by one or two substituent(s) selected from the group consisting of a C1-2 alkyl group, a C1-2 alkoxy group and a halo atom, furthermore geometric and/or optical isomers and/or pharmaceutically suitable acid addition salts thereof.