Patent ID: 6136810
Filing Date: 2000-10-24
Classification: A61P,C07D

Abstract:
A pyrido[ 2,3-d]pyrimidine compound represented by the following formula (III) or a pharmaceutically acceptable salt thereof: ##STR31## in the above formula, wherein X: an oxygen atom or a sulfur atom,R.sup.1 : a lower alkyl group, a cycloalkyl-lower alkyl group or a cycloalkyl group,R.sup.3 : a hydrogen atom, a halogen atom or a lower alkyl groupR.sup.4 : a hydrogen atom or a lower alkyl group,R.sup.5 : a cycloalkyl group which may be substituted with the same group of R.sup.6 ; a naphthyl group which may be substituted with the same group of R.sup.6 ; a five- or six-membered monocyclic hetero ring group having 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, which may be substituted with the same group of R.sup.6 and which may be condensed with a benzene ring; or a group represented by the formula ##STR32## and R.sup.6 : a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxyl group, a lower alkoxy group, a cyano group or a nitro group,R.sup.10 : a hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxy-lower alkyl group, a mercapto-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkylthio-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a lower alkanoylthio-lower alkyl group, a lower alkanoyl-lower alkyl group, a hydroxyimino-lower alkyl group, a lower alkoxyimino-lower alkyl group, a cycloalkyl group, an aryl group or a lower alkanoyl group,with the proviso that R.sup.10 is a group other than a hydrogen atom and a lower alkyl group when R.sup.5 is a group represented by the formula ##STR33## R.sup.6 is a halogen atom, a lower alkyl group or a lower alkoxy group, R.sup.1 is a lower alkyl group or a cycloalkyl group, R.sup.3 and R.sup.4 are both a hydrogen atom and X is an oxygen atom.