Patent ID: 6228399
Filing Date: 2001-05-08
Classification: A61K,Y10S

Abstract:
In a process of preparing cyclosporin microparticles, the process comprising reducing the particle size by sonication, homogenization, milling, microfluidization and precipitation, or recrystallization and precipitation of the cyclosporin using antisolvent and solvent precipitationthe improvement comprising the steps of:(1) prior to or during particle size reduction, mixing the cyclosporin particles with (a) a natural or synthetic phospholipid and (b) at least one non-ionic, anionic or cationic surfactant, and thereafter(2) applying energy to the mixture sufficient to produce volume-weighted mean particle size values of cyclosporin about 50% smaller than particles produced without the presence of the surfactant using the same energy input.