Patent ID: 6147266
Filing Date: 2000-11-14
Classification: C07C

Abstract:
A method for producing an acetylene alcohol compound in a continuous process, comprising the steps of:(i) saturating an acetylene gas in an aprotic solvent selected from the group consisting of dimethylformamide, dimethyl sulfoxide and N-methylpyrrolidone in a first reactor in the absence of liquid ammonia and alkali metal hydroxide;(ii) mixing the saturated acetylene solution with a ketone containing a --CH.sub.2 CHOCH.sub.2 -- to form a reactant mixture of said acetylene, ketone and solvent in a molar ratio of 1.0:0.2-3.0:1.0-4.0;(iii) feeding the reactant mixture into one of a second and third reactor, said second and third reactors containing a strongly basic quaternary ammonium hydroxide anion exchange resin, at a liquid hourly space velocity in the range of 0.1 to 5.0; and(iv) reacting the reactant mixture in the presence of said resin at a temperature of about 20 to 50.degree. C. under a pressure of about 10 to 30 kg/cm.sup.2 ;said second and third reactors being alternately operated to permit the regeneration of said resin in one reactor while said other reactor is being operated.