Patent ID: 6340686
Filing Date: 2002-01-22
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein R1 and R2 each represents a hydrogen atom, a hydroxy group, a C1-4 alkoxy group, a C1-4 alkoxy-carbonyl group or a C1-4 alkyl group which may be substituted by 1 to 5 substituents selected from the group consisting of (i) hydroxy, (ii) C1-7 acyloxy, (iii) benzoyloxy, (iv) amino which may be substituted by 1 or 2 substituents selected from the group consisting of C1-6 alkoxy-carbonyl, benzyloxycarbonyl, C1-4 acyl, C1-4 alkyl and C1-3 alkylsulfonyl, (v) C1-10 alkoxy, (vi) C3-7 cycloalkyloxycarbonyl-C1-3 alkoxy and (vii) C1-3 alkoxy-C1-3 alkoxy; R3 represents a hydrogen atom, a halogen atom, a hydroxy group or a C1-4 alkoxy group which may be substituted by 1 to 5 substituents selected from the group consisting of (i) hydroxy, (ii) C1-7 acyloxy, (iii) benzoyloxy, (iv) amino which may be substituted by 1 or 2 substituents selected from the group consisting of C1-6 alkoxy-carbonyl, benzyloxycarbonyl, C1-4 acyl, C1-4 alkyl and C1-3 alkylsulfonyl, (v) C1-10 alkoxy, (vi) C3-7 cycloalkyloxycarbonyl-C1-3 alkoxy and (vii) C1-3 alkoxy-C1-3 alkoxy; or two adjacent R3 may form, taken together, a C1-4 alkylenedioxy group; R4 represents a hydrogen atom or a C1-4 alkyl group; R6 represents a C1-4 alkyl group which may be substituted by 1 to 5 substituents selected from the group consisting of (i) hydroxy, (ii) C1-7 acyloxy, (iii) benzoyloxy, (iv) amino which may be substituted by 1 or 2 substituents selected from the group consisting of C1-6 alkoxycarbonyl, benzyloxycarbonyl, C1-4 acyl, C1-4 alkyl and C1-3 alkylsulfonyl, (v) C1-10 alkoxy, (vi) C3-7 cycloalkyloxycarbonyl-C1-3 alkoxy and (vii) C1-3 alkoxy-C1-3 alkoxy; or a group of the formula: wherein R5 represents a hydrogen atom, or R4 and R5 may together form n represents an integer of 0 to 5, or a salt thereof.