Patent ID: 7303889
Filing Date: 2007-12-04
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of identifying an agent that modulates the function of GPR43, said method comprising: (a) contacting a recombinant GPR43 polypeptide comprising the sequence of SEQ ID NO: 2 with a short chain fatty acid in the presence or absence of a candidate modulator under conditions permitting binding of said short chain fatty acid to said GPR43 polypeptide; and (b) measuring binding of said recombinant GPR43 polypeptide to said short chain fatty acid , wherein a decrease in binding in the presence of said candidate modulator, relative to binding in the absence of said candidate modulator, identifies said candidate modulator as an agent that modulates the function of GPR43.