Patent ID: 6995179
Filing Date: 2006-02-07
Classification: A61P,C07D

Abstract:
1. A pharmaceutical composition containing a dihydropyridine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein the composition is suitable for treating any of encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction or cerebral hemorrhage, Alzheimer's disease, AIDS related dementia, Parkinson's disease, progressive neurodegenerative disease, neuropathy caused by head injury, sharp pain caused by thromboangitis obliterans, pain after an operation, migraine, visceral pain, bronchial asthma, unstable angina, hypersensitive colon inflammation, and drug addiction withdrawal symptoms: wherein A represents a group of the following formula (2), thiophene-3-yl group, thiophene-2-yl group, furan-3-yl group, furan-2-yl group, pyridine-4-yl group, pyridine-3-yl group or pyridine-2-yl group: wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different from each other, and each represent a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkenyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkoxyl, a hydroxy-lower alkenyl, a halogeno-lower alkyl group, a halogeno-lower alkoxyl group, a halogeno-lower alkenyl group, an aryl-lower alkoxyl group, a lower alkoxycarbonyl group or an aroyl group, B represents a carbamoyl group, cyano group, nitro group, acetyl group or carboxyl group, C represents a hydrogen atom, methyl group, ethyl group or dimethoxymethyl group, D represents a hydrogen atom, a lower alkyl group, a hydroxy-lower alkyl group or an aryl-lower alkyl group, E represents a hydrogen atom, methyl group, ethyl group, dimethoxymethyl group or cyano group, F represents a group of the following formula (3), cyclohexyl group, thiophene-3-yl group, thiophene-2-yl group, furan-3-yl group, furan-2-yl group, pyridine-4-yl group, pyridine-3-yl group or pyridine-2-yl group, wherein R 6 , R 7 , R 8 , R 9 and R 10 may be the same or different from each other, and each represent a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkenyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkoxyl group, a hydroxy-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkoxyl group, a halogeno-lower alkenyl group, an aryl-lower alkoxyl group, a lower an alkoxycarbonyl group or an aroyl group, X represents an interatomic bond, —CH Y is represented by a group of the following formulae (4), (7), (8), (11) or (12): wherein two of R 1 to R 3 may be bonded together to form a ring.