Patent ID: 6753332
Filing Date: 2004-06-22
Classification: A61P,C07D

Abstract:
A compound of the formula wherein is an aromatic heterocycle selected from the group consisting of m is 0, 1 or 2; X is N; wherein R1 is selected from the group consisting of: (a) (C1-C6)alkyl, (C2-C8)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkylcarbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, (C1-C6)alkoxyamido, (C1-C6)alkylthio, (C3-C7)carbocyclylthio, (C6-C10)arylthio, (C2-C9)heteroarylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C6-C10)aryloxy, (C2-C9)heteroaryloxy, (C2-C9)heterocyclylcarbonyl, or (C1-C6)alkylcarbonyl-N(R2)â€”; (b) phenyl optionally substituted by one to three substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C8)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C9)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (c) phenyl fused to a saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring; â€ƒwherein either of said phenyl or said fused saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring is optionally substituted by one to two substituents per ring, wherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C8)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (d) phenyl fused to a saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NR2â€”, â€”Sâ€” and â€”Oâ€”; â€ƒwherein either of said phenyl or said fused saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl is optionally substituted with one to two substituents per ring; â€ƒwherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (e) (3- to 7-membered)-carbocyclic optionally containing one or two double bonds; wherein said (3- to 7-membered)-carbocyclic may also be optionally substituted by one to three substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (f) (5- to 7-membered)-carbocyclic fused to a saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring; wherein said (5- to 7-membered)-carbocyclic may optionally contain one or two double bonds; wherein either of said (5- to 7-membered)-carbocyclic or said fused saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring is optionally substituted by one to two substituents per ring, wherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl, N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (g) (5- to 7-membered)-carbocyclic fused to a saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NR2â€”, â€”Sâ€” and â€”Oâ€”; wherein said (5- to 7-membered)-carbocyclic may optionally contain one or two double bonds; wherein either of said (5- to 7-membered)-carbocyclic or said fused saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl is optionally substituted with one to two substituents per ring; wherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (h) saturated, partially saturated or aromatic (5- to 6-membered) heterocyclyl containing one to four ring heteroatoms independently selected from the groups consisting of â€”N&boxH;, â€”NR2â€”, â€”Oâ€”, and â€”Sâ€”; wherein said (5- to 6-membered) heterocyclyl is optionally substituted by one to three substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl, N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; (i) saturated, partially saturated or aromatic (5- to 6-membered) heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NR2â€”, â€”Sâ€” and â€”Oâ€”; wherein said saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl is fused to a saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring; wherein either of said saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl ring or said fused saturated, partially saturated or aromatic (5- to 7-membered)-carbocyclic ring is optionally substituted by one to two substituents per ring; wherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; and (j) saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NR2â€”, â€”Sâ€”, and â€”Oâ€”; wherein said saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl is fused to a saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of â€”N&boxH;, â€”NR2â€”, â€”Sâ€” and â€”Oâ€”; wherein either of said saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl or said fused saturated, partially saturated or aromatic (5- to 6-membered)-heterocyclyl is optionally substituted with one to two substituents per ring; wherein said substituents are independently selected from the group consisting of halo, hydroxy, cyano, mercapto, hydroxycarbonyl, nitro, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido N-(C1-C6)alkoxyamido, (C1-C6)alkylcarbonyloxy, (C1-C6)alkylcarbonyl-N(R2)â€”, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl, (C6-C10)aryl and (C2-C9)heterocyclyl; â€ƒwherein each of said R1 (a), (b), (c), (d), (e), (f), (g), (h), (i), or (j) (C1-C6)alkyl group wherever they occur may optionally be substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, carbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C1-C6)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C1-C10)arylamido, (C1-C6)alkoxyamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, and (C1-C6)alkylcarbonyloxy; R2 is hydrogen or (C1-C6)alkyl; R3 is hydrogen, halo, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)carbocyclyl, (C1-C6)alkylcarbonyl-, formyl, formamidyl, cyano, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)atkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl, N-(C6-C10)arylamino amino-SO2â€”, N-(C1-C6)alkylamino-SO2â€”, N,N-[(C1-C6)alkyl]2amino-SO2â€”, (C6-C10)arylamino-SO2â€”, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkoxyamido, (C1-C6)alkylthio, (C6-C10)arylthio, (C2-C9)heteroarylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2-amino, or (C1-C6)alkylcarbonyl-N(R2)â€”; â€ƒwherein each of said R3 (C1-C6)alkyl group wherever they occur may optionally be substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, carbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N(C1-C6)alkyl-N-(C6-C10)arylamido (C1-C6)alkoxyamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, and (C1-C6)alkylcarbonyloxy; R4 is (C1-C6)alkyl, (C3-C7)carbocyclyl, (C6-C10)aryl, (C2-C9)heteroaryl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido formyl-N(R2)â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, (C1-C6)alkyloxycarbonyl-N(R2)â€”, or (C1-C6)alkyl-SO2-amino; â€ƒwherein each of said R4 (C1-C6)alkyl group wherever they occur may optionally be substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, (C2-C8)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, carbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamino (C1-C6)alkoxyamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, and (C1-C6)alkylcarbonyloxy; R5 is hydrogen, halo, hydroxy, mercapto, (C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one to three halogen atoms, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, cyano, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonyloxy, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido nitro, or (C1-C6)alkylthio; wherein each of said R5 (C1-C6)alkyl group wherever they occur may optionally be substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, carbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, (C1-C6)alkoxyamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, and (C1-C6)alkylcarbonyloxy; R6 is hydrogen, halo, hydroxy, mercapto, (C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one to three halogen atoms, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, cyano, formyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonyloxy, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)aryl amido, nitro, or (C1-C6)alkylthio; wherein each of said R6 (C1-C6)alkyl group wherever they occur may optionally be substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)carbocyclyl, (C1-C6)alkoxy, carbonyl, formyl, formamidyl, (C1-C6)alkylcarbonyl, cyano, mercapto, nitro, hydroxycarbonyl, (C1-C6)alkoxycarbonyl, amino, N-(C1-C6)alkylamino, N,N-[(C1-C6)alkyl]2amino, N-(C3-C7)carbocyclylamino, N-(C6-C10)arylamino, N-(C1-C6)alkyl-N-(C6-C10)arylamino, N-(C2-C9)heteroarylamino, amido, N-(C1-C6)alkylamido, N,N-[(C1-C6)alkyl]2amido, N-(C6-C10)arylamido, N-(C1-C6)alkyl-N-(C6-C10)arylamido, (C1-C6)alkoxyamido, (C6-C10)aryl, (C6-C10)aryloxy, (C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heteroarylcarbonyl, (C1-C6)alkylthio, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkylcarbonyl-N(R2)â€”, and (C1-C6)alkylcarbonyloxy; â€ƒand a pharmaceutically acceptable salt thereof.