Patent ID: 8498821
Filing Date: 2013-07-30
Classification: C12Q,G16B,G16H,Y02A

Abstract:
1. A method of classifying a therapeutic intervention for arresting or killing malignant melanoma (MM) cells, comprising: (a) from a panel of MM cells classified according to genomic subgroups, selecting at least one MM cell line from each subgroup, wherein the panel is assembled from a method comprising: (b) contacting the at least one MM cell from each subgroup with the therapeutic intervention; (c) assaying the effectiveness of the therapeutic intervention to arrest or kill the at least one MM cell from each subgroup; (d) classifying the therapeutic intervention according to the determined effectiveness of the therapeutic intervention to arrest or kill the at least one MM cell from each subgroup, wherein the plurality of samples, m, consists of SKMEL119, HS944, WM1366, WM88; WM3248; 1205LU; 451LU, SKMEL19, SKMEL28, SKMEL30, SKMEL63; WM35, WM983, WM983C, WM3211, M14, MEWO, SKMEL2, SKMEL5, UACC257, UACC62, WM122, WM13662, WM239A, WM32112, WM32482, WM793B, and 501MEL, and MALME3M and WM882, and wherein when the therapeutic intervention arrests or kills the at least one MM cell from a first subgroup, but not another subgroup, it indicates specificity of the therapeutic intervention to arrest or kill MM cells of the first subgroup.