Patent ID: 6800638
Filing Date: 2004-10-05
Classification: A61P,C07D

Abstract:
A compound of formula I (a) denotes a phenyl group which may be unsubstituted or substituted with 1, 2 or 3 substituents independently selected from a halogen atom, an (1-4C)alkyl-, trifluoromethyl-, hydroxy-, (1-4)alkoxy-, benzyloxy-, (1-3C)alkylenedioxy-, nitro-, amino-, (1-4C)alkylamino-, di[(1-4C)alkyl]amino-, (1-4C)alkanoyl-amino-, or a phenyl group, which may be unsubstituted or substituted by 1, 2, or 3 substituents independently selected from a chlorine atom, an (1-4C)alkyl-, trifluoromethyl-, hydroxy-, (1-4C)alkoxy-, (1-3C)alkylenedioxy-, nitro-, amino-, (1-4C)alkylamino-, di[(1-4C)alkyl]amino-, and a (1-4C)alkanoylamino group, or (b) denotes an indolyl group which may be unsubstituted or substituted with 1, 2 or 3 substituents independently selected from a halogen atom, an (1-4C)alkyl-, trifluoromethyl-, hydroxy-, (1-4C)alkoxy-, benzyloxy-, (1-3C)alkylenedioxy-, nitro-, amino-, (1-4C)alkylamino-, di[(1-4C)alkyl]amino-, or a (1-4C)alkanoylamino-group, R1 and R2 are the same as or different from each other and are a hydrogen atom, an (1-4C)alkyl-, a trifluoromethyl group, or an aryl group, X is a straight chain alkylene group comprising 5, 6 or 7 carbon atoms, wherein one CH2 group may be replaced by an oxygen or a sulfur atom, or wherein 2 carbon atoms form a C&boxH;C double bond, and which is either unsubstituted or substituted by one or two substituents selected from (1-4C)alkyl and halogen atoms, or a pharmaceutically acceptable salt thereof.