Patent ID: 6271368
Filing Date: 2001-08-07
Classification: A61K,A61P,C07K

Abstract:
An isolated nucleic acid molecule(a) comprising a nucleic acid sequence as depicted in FIG. 4c or encoding a protein or preproprotein comprising the amino acid sequence as depicted in FIG. 4c (SEQ ID NOS: 34 and 35); or(b) comprising a nucleic acid sequence encoding a fragment of a protein or preproprotein according to (a) having more of the following biological activities: cytotoxicity, immunostimulation, endorphin stimulation, stimulation of release of inflamatory cytokines, apoptosis induction or antigenicity; or(c) comprising a nucleic acid sequence that differs from the nucleic acid molecule according to (a) or (b) due to the degeneracy of the genetic code, but which encodes a polypeptide having a biological activity indicated in (b); or(d) comprising a nucleic acid sequence that specifically hybridizes to primer RMLA2 (SEQ ID NO:2) in 10 mM Tris-HCl, 1.5 mM MgCl.sub.2, 50 mM KCl, at 50.degree. C. at pH 8.3; and encodes a polypeptide having a biological activity indicated in (b).