Patent ID: 8741336
Filing Date: 2014-06-03
Classification: A61K,A61M,A61N,A61P

Abstract:
1. A programmable transdermal drug delivery device comprising: (a) an interface for coupling to the skin of a subject; (b) a reservoir storing a quantity of an active substance, carrier materials, or a combination thereof; (c) a delivery mechanism for modulating the quantity of the active substance supplied from the reservoir to the interface in response to a control signal; (d) an electronic programmable timing mechanism coupled to the delivery mechanism and configured to generate the control signal according to a programmed administration schedule; (e) a mechanism for removing the active substance and/or carrier materials from the interface, which functions to stop permeation or dosing of the active substance, while the device is maintained in contact with the skin of the subject; and (f) a permeation enhancer selected from the group consisting of ethanol, isopropanol, propylene glycol, polyethylene glycol, amino acids, oleic acid, oleyl alcohol, long chain fatty acids, ethoxydiglycol, sodium xylene sulfonate, N-methylpyrrolidone, laurocapram, alkanecarboxylic acids, dimethylsulfoxide, polar lipids, and N-methyl-2-pyrrolidone.