Patent ID: 8252294
Filing Date: 2012-08-28
Classification: A61P,C07K,C12N,C12Q,G01N,Y02A

Abstract:
1. An antimalarial drug which comprises as an active ingredient a compound that inhibits the activity of a protein encoded by an isolated DNA according to any one of (a) to (e), which encodes a protein of a malaria parasite having GlcN-PI acyltransferase activity: (a) a DNA encoding a protein consisting of the amino acid sequence of SEQ ID NO: 2 or 4, (b) a DNA consisting of the nucleotide sequence of SEQ ID NO: 1 or 3, (c) a DNA hybridizing to DNA consisting of the nucleotide sequence of SEQ ID NO: 1 or 3 under stringent conditions, wherein the stringent conditions are hybridization in 4×SSC at 65° C. followed by washing in 0.1×SSC at 65° C. for one hour, (d) a DNA encoding a protein which consists of the amino acid sequence of SEQ ID NO: 2 or 4, in which 5 amino acids or fewer in SEQ ID NO: 2 or 4 have been added, deleted, substituted, and/or inserted, and (e) a DNA encoding a protein which has more than 95% identity to the amino acid sequence of SEQ ID NO: 2 or 4.