Patent ID: 8846735
Filing Date: 2014-09-30
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method for preparing an anti-viral pharmaceutical formulation for pulmonary delivery to a patient in need of same, which method comprises forming an aerosolized solution of said anti-viral formulation by electrohydrodynamic spraying, wherein said anti-viral formulation comprises a compound, or a pharmaceutically acceptable salt thereof, having the formula: wherein: R —NR 5 R 6 , —SO 2 NR 7 R 8 , hydroxyalkyl, hydroxyalkoxy, polyhydroxyalkyl, alkoxyalkoxy, polyfluoroalkyl, dialkylaminoalkyl, R 9 , —OR 9 , and HET; n being an integer from 1 to 4; R R R R or R or R said phenyl and heterocyclic radical substituents being at least one selected from the group consisting of alkyl, amino, hydroxy, carbonyl, monoalkylamino, dialkylamino, halogen, and alkoxy; R R HET represents an unsubstituted or substituted five to seven membered heterocyclic ring containing one to four heteroatoms independently selected from nitrogen, oxygen or sulfur, whereby the point of attachment to the heterocyclic ring is not at a nitrogen atom, said heterocyclic ring substituents being one or more radicals selected from the group consisting of alkyl, amino, hydroxy, carbonyl, oxo, monoalkylamino, and dialkylamino, and wherein HET is other than pyridine when R R R