Patent ID: 6458768
Filing Date: 2002-10-01
Classification: C07D

Abstract:
A compound which is a benzoheterocyclic distamycin derivative of formula: wherein:n is 2, 3 or 4; A is a heteroatom selected from O and S or is a group NR, wherein R is hydrogen or C1-C4 alkyl; B is CH or N; R1 is hydrogen or C1-C4 alkyl; G is selected from the group consisting of: and â€”Câ‰¡N â€ƒwherein R5, R6, R7, R8, R9, R10, R11 and R12 are, independently from each other, hydrogen or C1-C4 alkyl; T is a group of formula (II) or (III) as defined below â€ƒwherein p is 0 or 1; R2 and R3 are, independently from each other, hydrogen, C1-C4 alkyl optionally substituted by one or more fluorine atoms, or C1-C4 alkoxy; R4 is C1-C4 alkyl or C1-C3 haloalkyl; X1 and X2 are halogen atoms; or a pharmaceutically acceptable salt thereof; provided that at least one of R5, R6 and R7 is alkyl.