Patent ID: 8440705
Filing Date: 2013-05-14
Classification: A61K,A61P

Abstract:
1. A method of inhibiting or preventing α-synuclein toxicity and/or fibril formation, inhibiting or preventing α-synuclein fibril growth, and/or causing disassembly, disruption, and/or disaggregation of α-synuclein fibrils and α-synuclein-associated protein deposits in a patient, comprising administering to the patient a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is S; Y is NRR′; where R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or aralkyl, and R′ is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or aralkyl; Z is a direct bond or NR; R n is 0 to 4; R (i) hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroarylium, cycloalkyl, heterocyclyl, C(A)R (ii) any two R A is O, S or NR R R D is O or NR a is 0, 1 or 2; when a is 1 or 2, R when a is 0, R R (a) hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroarylium, cycloalkyl, heterocyclyl, C(A)R (b) any two of R R (i) R (ii) any two of R R R R (i) R (ii) R R R R R wherein Y, Z, R each Q each Q R R R R