Patent ID: 6774129
Filing Date: 2004-08-10
Classification: A61P,C07D

Abstract:
A compound of formula an N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein: each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; Alk is C1-6alkanediyl; n is 1 or 2; p is 0, 1 or 2; D is 1- or 2-benzimidazolyl, 2(3H)benzoxazolone-3-yl or a radical of formula wherein each X independently represents O, S or NR12; R2 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, amino or mono- or di(C1-6alkyl)amino; R4, R5, R6, R7, R8, R10, R11 and R12 each independently are hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl or aryl; or R3 and R4 taken together may form a bivalent radical â€”R3â€”R4â€” of formula wherein one or two hydrogen atoms of said radicals (a-1) to (a-5) each independently may be replaced by halo, C1-6alkyl, arylC1-6alkyl, trifluoromethyl, amino, hydroxy, C1-6alkyloxy or C1-10alkylcarbonyloxy; or where possible, two geminal hydrogen atoms may be replaced by C1-6alkylidene or arylC1-6alkylidene; or â€”R3â€”R4â€” may also be wherein one or where possible two or three hydrogen atoms in said radicals (a-6) to (a-14) each independently may be replaced by C1-6alkyl or aryl; and aryl is phenyl or phenyl substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, trifluoromethyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, mercapto, amino, mono- and di(C1-6alkyl)amino, carboxyl, C1-6alkyloxycarbonyl and C1-6alkylcarbonyl.