Patent ID: 6380398
Filing Date: 2002-04-30
Classification: A61K,A61P,C07D

Abstract:
A compound of formula II whereinat least one of the bonds in the five-membered ring is a double bond; R2 is H; C1-C10 alkyl optionally substituted with one or more R4 independently; C2-C10 alkenyl optionally substituted with one or more R4 independently; C2-C10-alkynyl optionally substituted with one or more R4 independently; C3-C10-cycloalkyl optionally substituted with one or more R4 independently; C5-C10 cycloalkenyl optionally substituted with one or more R4 independently; aryl optionally substituted with one or more R5 independently; or heteroaryl optionally substituted with one or more R5 independently; R3 is H; C1-C10 alkyl optionally substituted with one or more R4 independently; C2-C10 alkenyl optionally substituted with one or more R4 independently; C2-C10-alkynyl optionally substituted with one or more R4 independently; C3-C10 cycloalkyl optionally substituted with one or more R4 independently; C5-C10 cycloalkenyl optionally substituted with one or more R4 independently; aryl optionally substituted with one or more R5 independently and optionally fused to a C3-C10 cycloalkane; or heteroaryl optionally substituted with one or more R5 independently optionally fused to a C3-C10 cycloalkane; R2 is optionally connected R3 by a saturated or unsaturated bridge containing 1-3 carbon atoms, nitrogen atoms, oxygen atoms or sulphur atoms independently, or a valence bond, thus forming a ring, said ring is optionally fused to an aryl or heteroaryl, optionally substituted by one or more R5 independently; R4 is cycloalkyl, aryl optionally substituted with one or more R5 independently; heteroaryl optionally substituted with one or more R5 independently; amino optionally substituted with one or more R6 independently; â€”SOâ€”R6; â€”SO2â€”R6; â€”COâ€”R6; â€”COOâ€”R6, â€”CONHâ€”R6; â€”CON(R6)2; â€”Oâ€”R6; â€”Sâ€”R6; carboxy; acetamido; cyano; nitro; halogen; hydroxy; trifluoromethyl; trifluoromethoxy; sulfamoyl; carbamoyl; hydroxymethyl; R5 is halogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 alkylamino, C1-C10 dialkylamino, benzyl, benzyloxy, hydroxymethyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, N-hydroxyimino, cyano; carboxy; acetamido; hydroxy; sulfamoyl, carbamoyl; R6 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10-alkynyl, C3-C10-cycloalkyl, C5-C10 cycloalkenyl where any one of said alkyl, alkenyl, alkynyl, cycloalkyl, or cykloalkenyl is optionally substituted with aryl optionally substituted with one or more R5 independently or heteroaryl optionally substituted with one or more R5 independently; benzyl, phenethyl; aryl optionally substituted with one or more R5 independently; or heteroaryl optionally substituted with one or more R5 independently with the proviso that R2 and R3 cannot both be H; or a salt thereof with a pharmaceutically acceptable acid or base.