Patent ID: 6586475
Filing Date: 2003-07-01
Classification: A61P,C07C,C07D

Abstract:
An amyloid-&bgr; protein production and/or secretion inhibitor which comprises a compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted; X is a bivalent group selected from â€”Oâ€”, â€”Sâ€”, â€”COâ€”, â€”SOâ€”, â€”SO2â€”, â€”NR8â€”, â€”CONR8â€”, SO2NR8 and â€”COOâ€” wherein R8 hydrogen atom, a hydrocarbon group which may be substituted or acyl, or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two of said bivalent groups; Y is [1] a group represented by the formula: â€”(CH2)q1CONR9(CH2)r1â€” wherein each of q1 and r1 is an integer of 0 to 3 and their sum is an integer of not more than 3, R9 is hydrogen atom or C1-6 alkyl which may be halogenated or C1-6 alkyl-carbonyl which may be halogenated, or [2] a group represented by the formula: â€”(CH2)q2COO(CH2)r2â€” wherein each of q2 and r2 is an integer of 0 to 3 and their sum is not more than 3; R1 and R2 are hydrogen atom or C1-6 alkyl which may be substituted, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted; and ring A is a phenylene, provided that 4,4â€²-[[1,1â€²-biphenyl]-2,5-diylbis(oxy)]bis[benzoic acid] dihydrazide is excluded, or a salt thereof.