Patent ID: 8053569
Filing Date: 2011-11-08
Classification: A61K,A61P,C07K

Abstract:
1. A single nucleic acid sequence comprising a first sequence coding for a light chain of an immunoglobulin and second sequence coding for a heavy chain of the immunoglobulin, wherein: (a) the immunoglobulin is specific for an endogenous BBB receptor-mediated transport system; (b) either the first sequence further codes for a peptide that is expressed as a fusion protein of the peptide covalently linked at its amino terminus to the carboxy terminus of the light chain or the second sequence further codes for a peptide that is expressed as a fusion protein of the peptide covalently linked at its amino terminus to the carboxy terminus of the heavy chain; (c) the peptide is a neurotherapeutic peptide selected from the group consisting of: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-4/5, neurotrophin (NT)-3, epidermal growth factor (EGF), transforming growth factor (TGF)-α, glial-derived neurotrophic factor (GDNF), neurturin, platelet-derived growth factor (PDGF), artemin bone morphogenetic protein (BMP), erythropoietin (EPO), and saposins; and (d) the neurotherapeutic peptide and the immunoglobulin each retains more than 10% of their activities, compared to their respective activities as separate entities.