Patent ID: 7947282
Filing Date: 2011-05-24
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method for treating a disease or condition, comprising non-systemically administering to a mammal at a pre-determined site and having a disease or condition a solid-phase agent comprising a binding agent capable of binding platelets, said solid-phase agent being greater than about 1 micron in size, and subsequently inducing a thrombus in vivo at or near said site, comprising: capturing platelets by binding the platelets to the platelet binding agent immobilized on or within the solid-phase agent, inducing activation of the platelets, and allowing a thrombus to form; thereby providing a beneficial result in treating said disease or condition; and administering at least one other therapy, thereby providing a beneficial result in treating said disease or condition, wherein said disease or condition is selected from the group consisting of hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), hemorrhagic stroke, saphenous vein side branches in saphenous bypass graft surgery, aortic aneurysm, vascular malformations, and solid tumors; embolization of tumor vasculature prior to organ transplantation, and embolization of vasculature prior to tissue or organ resection; any pathological condition where blood is involved or present, comprising cancer, hyperplastic cells, excessive bleeding or arteriovenous (AV) malformations, or which are hemorrhaging; solid hyperplastic tissue; cancer pain, uterine fibroids, pelvic congestion, menorrhagia, varicoceles, hemoptysis, aneurysms, visceral artery aneurysms, pseudoaneurvsms and endoleaks; peripheral vascular disease (PVD), and high blood pressure; and any condition that includes a risk of hemorrhage, including but not limited to coagulation factor deficiencies, and hemophilia.