Patent ID: 6770646
Filing Date: 2004-08-03
Classification: A61P,C07D

Abstract:
A compound of the formula wherein B represents a nitrogen (N) atom; D represents a nitrogen (N) atom; E represents a group CR3;R1 represents a group NRâ€²Râ€³ where Râ€² represent a hydrogen atom or a C1-C6 alkyl group, Râ€³ represents a C1-C6 alkyl group, or Râ€² and Râ€³ together with the nitrogen atom to which they are attached form a 3- to 7-membered saturated heterocyclic ring, or R1 represents a C1-C6 alkyl, C1-C6 alkoxy, C1 -C3-alkyloxyC1-C3-alkyl, C3-C6-cycloalkyloxyC1-C3-alkyl, C3-C6 alkenyl, phenyl, C3-C7 cycloalkyl, C3-C5 cycloalkylmethyl or C3-C7 cycloalkenyl group, each of which is optionally substituted by one or more halogen atoms; R2 represents a methyl group, or a C1-C6 alkyl group optionally substituted by a C1-C6 alkoxy group other than in the 1-position; R3 represents a hydrogen atom or a group X-R5 or X-Ar1; X represents a group â€”Oâ€”, S(O)n, SO2N(R6); C(&boxH;O)N(R6); n is 0, 1 or 2; R5 represents an optionally substituted alkyl or alkenyl group, or, additionally, in the case where X represents SO2N(R6) or C(&boxH;O)N(R6), R5 and R6 together with the nitrogen atom to which they are attached may form an optionally substituted 3- to 7-membered heterocyclic ring; Ar1 represents an optionally substituted phenyl or pyridyl group; represents a hydrogen atom, C1-C6 alkyl or is linked to R5 as defined above; R4 represents a group CHR7Ar2 or Ar3 Ar2 represents an aryl or heteroaryl group which is optionally substituted; Ar3 represents an acenaphthenyl, indanyl or fluorenyl group, each of which is optionally substituted; and R7 represents a hydrogen atom or a C1-C4 alkyl group; or a pharmaceutically-acceptable salt or solvate thereof.