Patent ID: 8591939
Filing Date: 2013-11-26
Classification: A61K,A61P

Abstract:
1. A percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer comprises (a) Fentanyl, (b) two kinds of polyisobutylene having different molecular weights, (c) a tackifier, and (d) an organic liquid compatible with the two kinds of polyisobutylene and the tackifier, wherein the organic liquid comprises a combination of (i) a fatty acid alkyl ester comprising a higher fatty acid having 12 to 16 carbon atoms and a lower monovalent alcohol having 1 to 4 carbon atoms and (ii) a branched long-chain alcohol having 16 to 22 carbon atoms in a ratio of 1:0.2-1:5 by weight, wherein the fatty acid alkyl ester is isopropyl myristate, and the branched long-chain alcohol is at least one selected from isostearyl alcohol and octyldodecanol, wherein the organic liquid is present in an amount of not more than 20% of the total weight of the adhesive layer, and wherein Fentanyl is present in an amount of 1.5-2.5% of the total weight of the adhesive layer.