Patent ID: 6346536
Filing Date: 2002-02-12
Classification: A61K,C07D

Abstract:
A compound of formula I: whereinR1, R2, R3, R4, R5, R6, R7, or R8 is hydrogen, C1 alkyl, C2-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalky, C5-C7 cycloalkenyl, or Ar1, wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl groups may be optionally substituted with C3-C8 cycloalkyl, C3 or C5 cycloalkyl, C5-C7 cycloalkenyl, halo, hydroxyl, nitro, trifluoromethyl, C1 alkyl, C2-C6 straight or branched chain alkyl or alkenyl, C1-C4 alkoxy, C2-C4 alkenyloxy, phenoxy, benzyloxy, or Ar1, and where Ar1 is 1-naphthyl, 2-naphthyl, 2-indolyl, 3-indolyl, 4-indolyl, 2-furyl, 3-furyl, tetrahydrofuranyl 2-thienyl, 3-thienyl, 4-thienyl, 2-pyridyl, 3-pyridyl, or 4-pyridyl, or phenyl, each having one to five substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C1 alkyl, C2-C6 straight or branched alkyl or alkenyl, C1-C4 alkoxy or C2-C4 alkenyloxy, phenoxy, and benzyloxy;X is O; with the proviso that R8 is not Me or hydrogen when there is a double bond between C1 and C2, and R1-R7 are all hydrogen; ora pharmaceutically acceptable salt, hydrate, or a mixture thereof.