Patent ID: 9017312
Filing Date: 2015-04-28
Classification: A61K,A61M

Abstract:
1. An implantable medical device for controlled drug delivery device comprising: a first drug portion that comprises a first drug housing loaded with a first drug formulation in a solid or semi-solid form which comprises a first drug which has a high solubility, wherein the first drug housing comprises a first wall that is permeable to water but is substantially impermeable to the first drug and has at least one aperture through the first wall, the first drug portion being configured to release the first drug from the first drug housing through the at least one aperture primarily via osmotic pressure in vivo according to a first release profile; and a second drug portion that comprises a second drug housing loaded with a second drug formulation in a solid or semi-solid form which comprises a second drug which has a low solubility, wherein the second drug housing comprises a second wall that is permeable to water and to the second drug, the second drug portion being configured to release the second drug from the second drug housing by diffusion through the second wall in vivo according to a second release profile; and a retention portion operably associated with both the first and second drug portions.