Patent ID: 6833353
Filing Date: 2004-12-21
Classification: A61K,A61P,Y10S

Abstract:
A method of inhibiting matrix metalloprotease production in a cell in need thereof, comprising administering to said cell an effective concentration of one or more macrolides of the following formula (I): wherein each of adjacent pairs of R1 and R2, R3 and R4, and R5 and R6 are independently (a) two adjacent hydrogen atoms, where R2 may be an alkyl group, or (b) form a bond so that the carbon atoms to which they are attached have a double bond therebetween; R7 is a hydrogen atom, a hydroxy group, a protected hydroxyl group, or an alkoxy group, or an oxo group together with R1; R8 and R9 are independently a hydrogen atom or a hydroxy group; R10 is a hydrogen atom, an alkyl group, an alkyl group substituted by one or more hydroxy groups, an alkenyl group, an alkenyl group substituted by one or more hydroxy groups, or an alkyl group substituted by an oxo group; X is an oxo group, a hydrogen atom and a hydroxy group, a hydrogen atom and a hydrogen atom, or a group represented by the formula â€”CH2Oâ€”; Y is an oxo group, a hydrogen atom and a hydroxy group, a hydrogen atom and a hydrogen atom, or a group represented by the formula Nâ€”NR11R12 or Nâ€”OR13; R11 and R12 are independently a hydrogen atom, an alkyl group, an aryl group or a tosyl group; R13, R14, R15, R16, R17, R18, R19, R22 and R23 are independently a hydrogen atom or an alkyl group; R24 is an optionally substituted ring system that may contain one or more heteroatoms; n is an integer of 1 or 2; and wherein Y, R10 and R23, together with the carbon atoms to which they are attached, may represent a saturated or unsaturated 5- or 6-membered nitrogen, sulfur and/or oxygen containing heterocyclic ring optionally substituted by one or more groups selected from the group consisting of an alkyl, a hydroxy, an alkoxy, a benzyl, a group of the formula â€”CH2Se(C6H5), and an alkyl substituted by one or more hydroxy groups, or a pharmaceutically acceptable salt thereof.