Patent ID: 6399778
Filing Date: 2002-06-04
Classification: A61P,C07D

Abstract:
A process for preparing a crystalline solvate of a compound of the formula: which comprises:a) acylating a benzothiophene of the formula: â€ƒwherein: R4 is C1-C4 alkoxy; and R5 is C1-C4 alkyl; with an acylating agent of the formula: â€ƒwherein: R6 is chloro, bromo, or hydroxyl; in the presence of a solvent and boron trichloride;b) dealkylating the acylated benzothiophene by reacting said acylated benzothiophene with additional boron trichloride to prepare a compound of the formula: c) isolating the crystalline solvate.