Patent ID: 9019599
Filing Date: 2015-04-28
Classification: G01N,G02B

Abstract:
1. A total internal reflection fluorescence imaging apparatus, comprising: a metal nanostructure layer including a metal thin film and a nanostructure formed on the metal thin film; a light source unit configured to provide incident light such that the incident light is totally reflected off the metal nanostructure layer and an evanescent wave localized in a horizontal direction of the light source unit is created between the metal nanostructure layer and a biological specimen arranged on the metal nanostructure layer; and a fluorescence image extracting unit configured to extract and image a fluorescence signal generated by the biological specimen due to the evanescent wave localized in a horizontal direction of the fluorescence image extracting unit, wherein the metal nanostructure layer further comprises a metal grid formed over the metal thin film, and a plurality of nanostructures are formed over the metal grid.