Patent ID: 7517643
Filing Date: 2009-04-14
Classification: C12N

Abstract:
1. A method of screening a library of compounds, comprising: (a) providing a plurality of bacteriophage, each of the bacteriophage displaying a compound other than a polypeptide expressed by the bacteriophage, different bacteriophage displaying different compounds and harboring different heterologous nucleic acid tags, wherein: each of the heterologous nucleic acid tags is inserted into the genome of the bacteriophage; each of the heterologous nucleic acid tags is a nucleic acid segment other than a segment that encodes for a polypeptide displayed on the bacteriophage; and each of the compounds is associated with a specific heterologous nucleic acid tag; (b) assaying the plurality of bacteriophage to identify at least one bacteriophage displaying at least one compound with a desired property; and (c) decoding the heterologous nucleic acid tag of the at least one bacteriophage to identify a characteristic of the at least one compound with the desired property.