Patent ID: 6599915
Filing Date: 2003-07-29
Classification: C07D

Abstract:
A method of treating a subject suffering from post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction or sexual dysfunction which comprises providing to the subject suffering from said condition, a therapeutically effective amount of a compound of formula I: whereinR1 is hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, alkyl of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; R2, R3, R4, R5 and R7 are, independently, hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms R6 is hydrogen or alkyl of 1 to 6 carbon atoms; A dotted line represents an optional double bond; A and D are selected from carbon substituted by R1 and nitrogen, provided that at least one of A and D is nitrogen; E and G are carbon, substituted by R1; Z is N or CR7; and n is an integer 0, 1 or 2; or pharmaceutically acceptable salts thereof.