Patent ID: 6136779
Filing Date: 2000-10-24
Classification: A61K,C07K,C12N,C12Q,Y02A

Abstract:
A method of specifically transcriptionally modulating the expression of a gene of interest which encodes a protein, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism, which comprises containing a eukaryotic cell, which expresses the gene, with a chemical at a concentration effective to specifically transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene of interest which is expressed by the cell, which chemical(a) does not naturally occur in the cell,(b) specifically transcriptionally modulates expression of the gene of interest, and(c) binds to a protein which either:(i) is not a receptor protein associated with a defined physiological effect, or(ii) if it is a receptor protein associated with a defined physiological effect, the chemical binds to said receptor protein through a domain which is not a ligand binding domain normally associated with the defined physiological effect.