Patent ID: 6831071
Filing Date: 2004-12-14
Classification: A61K,C12N,C12P

Abstract:
A process for synthesis of biologically active compounds from biologically inactive precursors with the aim to deliver said biologically active compounds to the target cells having specific RNA or DNA molecules, the process comprising:using a composition comprising at least two different oligomers chemically bound at their 5â€² and/or 3â€² end via a linking moiety to said biologically inactive precursors of biologically active compound, and said biologically inactive precursors comprising chemically active groups wherein said oligomers allow the hybridisation to a cellular RNA, DNA or dsDNA such that after hybridisation the distance between the 3â€² or 5â€² ends of said two oligomers coupled to the biologically inactive precursors is in the range of 0 to 8 ribo(deoxy)nucleotides and said hybridisation leads to a chemical coupling of said two precursors via said chemically active groups and/or said linking moieties and the intracellular synthesis of said biologically active compound in the target cells.