Patent ID: 6319663
Filing Date: 2001-11-20
Classification: C12Q,G01N

Abstract:
An assay method for identifying a substance useful for modulating POD structure or function in a test cell, said method comprising:a) contacting a test cell with a test substance,wherein the test substance is a protein, peptide, small organic molecule, carbohydrate, lipid, fungal extract, or plant extract,wherein said test cell expresses one or more retroviral proteins, including at least Tax, in an amount sufficient to upregulate a promoter of a gene encoding a POD-localized protein, andwherein the POD-localized protein is PML, Sp-100, CBP, PIF13, PIF31, ND52, ND55, or DipA, andb) assaying for the ability of the test substance to modulate POD function and/or structure in the test cell.