Patent ID: 6624246
Filing Date: 2003-09-23
Classification: A61K,A61P,C08G

Abstract:
A method for the preparation of a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer, comprising:providing a water-soluble and non-peptidic polymer having at least one terminal hydroxyl group; reacting the terminal hydroxyl group of the water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the water-soluble and non-peptidic polymer; providing a second polymer having a plurality of primary amino groups; and reacting the 1-benzotriazolylcarbonate ester of the water-soluble and non-peptidic polymer with at least two of the amino groups of the second polymer to form a cross-linked polymer.