Patent ID: 6562830
Filing Date: 2003-05-13
Classification: A61K

Abstract:
A method of treating a patient having precancerous lesions sensitive to a compound of the formula below in need of treatment, comprising administering to the patient a pharmacologically effective amount of a compound of the formula: wherein R1 and R2 are independently hydrogen, lower alkyl, lower alkoxy, lower alkyl thio, nitro, â€”CONR6R7, or â€”NR6R7; and R6 and R7 are independently hydrogen or lower alkyl optionally substituted by hydroxy provided that the carbon atom adjacent to the nitrogen atom is not substituted by hydroxy;R3 is hydrogen, lower alkyl or lower alkoxy; R4 is hydrogen, C2-C4 alkanoyl optionally substituted with NR8R9, (hydroxy) C2-C4 alkyl optionally substituted with NR8R9, CH&boxH;CHCO2R10, CH&boxH;CHCONR8R9, CH2CH2CO2R10, CH2CH2CONR8R9, SO2NR8R9, SO2NH(CH2)nNR8R9 or imidazolyl; and R8 and R9 are independently hydrogen or lower alkyl or together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino or 4-(NR6)-1-piperazinyl group wherein any of said groups is optionally substituted with CONR6R7; n is 2, 3 or 4; and R5 is lower alkoxy, lower alkenoxy, cyclo(lower)alkyl(lower)alkoxy, phenyl(lower)alkoxy, or phenyl(lower)alkoxy with the alkoxy substituted by 1 to 6 fluoro groups.