Patent ID: 7902169
Filing Date: 2011-03-08
Classification: A61P,C12N

Abstract:
1. A method of treating an eye disorder characterized by increased intraocular pressure (IOP) comprising topically administering to the corneal surface of the eye of a patient in need thereof a short interfering nucleic acid molecule (siNA) comprising a double-stranded nucleic acid region in an amount that reduces IOP in the eye of the patient, wherein said siNA targets adrenergic beta receptor 2, and wherein there is greater than 90% sequence identity or greater than 90% sequence complementarity between said double-stranded nucleic acid region and the portion of mRNA encoding adrenergic beta receptor 2 targeted by said siNA, wherein said portion comprises a nucleotide sequence selected from the group consisting of SEQ ID NOS: 139 and 1841.