Patent ID: 7456180
Filing Date: 2008-11-25
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a disease or condition mediated by stearoyl-CoA desaturase (SCD) in a mammal, wherein the method comprises administering to the mammal in need thereof a therapeutically effective amount of a compound of formula (Ia): wherein: x and y are each independently 1, 2 or 3; W is —N(R W is —N(R V is —C(O)—, —C(O)O—, —C(S)—, —C(O)N(R G and M are each —N═, and J and L are each —C(R each R R or R R or R each R each R or R or one of R R each R a stereoisomer, enantiomer ot tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein the mammal is a human, wherein the disease or condition is selected from the group consisting of fatty liver, non-alcoholic steatohepatitis, Type II diabetes, impaired glucose tolerance, insulin resistance, obesity, dyslipidemia, acne, and metabolic syndrome and any combination of these.