Patent ID: 6887474
Filing Date: 2005-05-03
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of inducing a thrombus in vivo comprising: administering a first agent that is a binding agent having administering an anti-ligand that specifically binds to the first ligand; administering a second agent that specifically binds to platelets, the second agent comprising von Willebrand factor and a second ligand that specifically binds to the anti-ligand; and binding platelets on the second agent and inducing activation of the platelets; thereby inducing a thrombus in vivo, wherein the first and second ligands and the anti-ligand consist of a complementary set of molecules that specifically bind to each other and are selected from the group consisting of biotin/avidin, zinc finger protein/dsDNA fragment, enzyme/inhibitor, hapten/antibody, ligand/receptor, homophylic peptides and leucine zipper sets.