Patent ID: 6231864
Filing Date: 2001-05-15
Classification: A61K,A61P,C07K,C12N,Y02A,Y10S

Abstract:
A strategically modified hepatitis B core protein conjugate comprising a strategically modified hepadnavirus nucleocapsid protein pendently linked to a hapten, wherein the strategically modified hepatitis B core protein comprises an amino acid sequence corresponding to the hepatitis B core protein amino acid sequence of SEQ ID NO:2 including the amino acid residues numbered about 10 to about 140 and additionally having an insert in the region corresponding to amino acid residues numbered about 50 to about 100, said insert (i) being 1 to about 40 amino acid residues in length, and (ii) containing a chemically-reactive amino acid residue, said hapten being pendently linked to said chemically-reactive amino acid residue.