Patent ID: 7402595
Filing Date: 2008-07-22
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by the formula wherein ring B′ is a benzene ring optionally having not more than two substituent(s); X′ is —CH R a phenyl group optionally substituted by substituent(s) selected from substituent group B or a heterocyclic group bonded via a ring-constituting carbon atom and optionally substituted by substituent(s) selected from the substituent group B; R a hydrocarbon group optionally having substituent(s) selected from the group consisting of a hydroxy group optionally substituted by a substituent selected from substituent group C, a thiol group optionally substituted by a substituent selected from the substituent group C, R R R R an optionally esterified or thioesterified carboxyl group, a carbamoyl group optionally N-mono- or N,N-di-substituted by subsuituent(s) selected from the group consisting of a 3 to 8-membered cyclic aminocarbonyl, an amino group optionally N-mono- or N,N-di-substituted by substituent(s) selected from the substituent group C, or a 3to 8-membered cyclic amino group; R a hydrogen atom, a halogen atom, a cyano group, a hydrocarbon group optionally substituted by substituent(s) selected from the substituent group B, a heterocyclic group optionally substituted by substituent(s) selected from the substituent group B, a hydroxy group optionally substituted by a substituent selected from the substituent group C, a thiol group optionally substituted by a substituent selected from the substituent group C, a sulfinyl group substituted by a substituent selected from the group consisting of a sulfonyl group substituted by a substituent selected from the group consisting of an amino group optionally N-mono- or N,N-di-substituted by substituent(s) selected from the substituent group C, a 3 to 8-membered cyclic amino group, a carbamoyl group optionally N-mono- or N,N-di-substituted by substituent(s) selected from the group consisting of a 3 to 8-membered cyclic aminocarbonyl, or an optionally esterified carboxyl group; the substituent group A consists of (1) a nitro group, (2) a hydroxy group, (3) an oxo group, (4) a cyano group, (5) a carbamoyl group, (6) a mono- or di-C (7) a mono- or di-C (8) a mono- or di-phenyl-carbamoyl group, (9) a mono- or di-benzyl-carbamoyl group, (10) a C (11) a C (12) a C (13) an amino-carbamoyl group, (14) a mono- or di-C (15) a mono- or di-phenylamino-carbamoyl group, (16) a carboxyl group, (17) a C (18) a sulfo group, (19) a halogen atom, (20) an optionally halogenated C (21) a C (22) a C (23) a C (24) a C (25) a C (26) a phenoxy group, (27) a phenoxy-C (28) a phenoxy-C (29) a C (30) a carbamoyloxy group, (31) a mono- or di-C (32) an optionally halogenated phenyl group, (33) an optionally hatogenated phenyl-C (34) an optionally halogenated phenyl-C (35) an optionally halogenated phenoxy group, (36) a pyridyloxy group, (37) a C (38) a C (39) a C (40) an optionally halogenated C (41) an optionally halogenated C (42) an optionally halogenated C (43) a C (44) a C (45) a mercapto group, (46) a thioxo group, (47) a benzyloxy group or benzylthio group optionally substituted by a substituent(s) selected from a halogen atom, carboxyl group and C (48) an optionally halogenated phenylthio group, (49) a pyridylthio group, (50) a phenylthio-C (51) a pyridylthio C (52) an optionally halogenated C (53) a phenylsulfinyl group, (54) a phenylsulfinyl-C (55) an optionally halogenated C (56) a phenylsulfonyl group, (57) a phenylsulfonyl-C (58) an amino group, (59) an arninosulfonyl group, (60) a mono- or di-C (61) a C (62) a benzoylamino wherein said benzoyl is optionally substituted by halogen atom, hydroxy group, carboxyl group, (63) a C (64) a C (65) a benzyloxycarbonylamino, (66) an optionally halogenated C (67) a carbamoylamino group, (68) a mono- or di-C (69) a mono- or di-C (70) phenylamino, (71) benzylamino, (72) a 4 to 6-membered cyclic amino group, (73) a 4 to 6-membered cyclic amino-carbonyl group, (74) a 4 to 6-membered cyclic amino-carbonyl-oxy group, (75) a 4 to 6-membered cyclic amino-carbonyl-amino group, (76) a 4 to 6-membered cyclic amino-sulfonyl group, (77) a 4 to 6-membered cyclic amino-C (78) a formyl, (79) a C (80) a benzoyl group, (81) a benzoyl group optionally substituted by halogen atom, (82) a 5 to 10-membered heterocyclic group wherein said heterocyclic group is optionally substituted by C (83) a 5 to 10-membered heterocycle-carbonyl group wherein said heterocyclic group is optionally substituted by C (84) a hydroxyimino group, (85) a C (86) an aryl group, and (87) an optionally halogenated linear or branched C (1) the substituent group A, (2) a C (3) a C (4) a phenyl-C (5) a mono- or di-C (6) a C (7) a C (8) a styryl group; and the substituent group C consists of (1) a hydrocarbon group optionally substituted by substituent(s) selected from the substituent group B, (2) R (3) R (4) R (5) R (6) an alkoxycarbonyl optionally substituted by substituent(s) selected from the substituent group A, (7) a carbamoyl optionally N-mono- or N,N-di-substituted by substituent(s) selected from the group consisting of (8) a 3 to 8-membered cyclic aminocarbonyl, and (9) a heterocyclic group optionally substituted by substituent(s) selected from the substituent group B; or a salt thereof, provided that 2-benzyl-1-oxo-4-phenyl-1,2-dihydro-isociuinoline-3-carboxamide is excluded.