Patent ID: 8945663
Filing Date: 2015-02-03
Classification: A61L

Abstract:
1. A method, comprising: providing an implantable medical device comprising a device body; optionally disposing a primer layer over an exposed surface of the device body; disposing a drug reservoir layer over an exposed surface of the device body or, if opted for, over the primer layer, wherein: the drug reservoir layer comprises: a first polymer that includes at least one constitutional unit having a carbon-hydrogen bond capable of radical formation, a UV and/or visible light sensitive therapeutic agent; and optionally, a UV or visible light blocker that absorbs UV or visible radiation at the wavelength(s) to which the therapeutic agent is sensitive; optionally disposing a topcoat layer over the drug reservoir layer wherein the topcoat layer comprises a second polymer, which may be the same as or different than the first polymer, wherein the second polymer has at least one constitutional unit having a carbon-hydrogen bond capable of radical formation, wherein if the topcoat layer is opted for it optionally further comprises a UV or visible light blocker that absorbs UV or visible radiation at the wavelength(s) to which the therapeutic agent is sensitive; disposing a UV or visible light active biobeneficial agent over the drug reservoir layer or, if opted for, over the topcoat layer; and, curing the device with UV or visible radiation wherein: a covalent bond is formed between the UV light active biobeneficial agent and the first polymer or, if a top coat is opted for, the second polymer, wherein the UV or visible light active biobeneficial agent comprises a biobeneficial agent to which a UV or visible light radical-forming entity has been covalently bonded.