Patent ID: 6500945
Filing Date: 2002-12-31
Classification: A61K,A61P,C07H,C07J,C07K,C12N,C12Q,C12Y

Abstract:
A composition of matter having the structure: wherein:Q is O or CH2; RD is O, S, methyl, alkoxy, thioalkoxy, amino or substituted amino; RE is O or S; RF is H or a blocking group; RX is H, OH, lower alkyl, substituted lower alkyl, F, Cl, Br, CN, CF3, OCF3, OCN, O-alkyl, substituted O-alkyl, S-alkyl, substituted S-alkyl, SOMe, ONO2, NO2, N3, NH2, NH-alkyl, substituted NH-alkyl, OCH2CH&boxH;CH2, OCH&boxH;CH2, OCH2CCH, OCCH, aralkyl, heteroaralkyl, heterocycloalkyl, polyalkylamino, or substituted silyl; BX is a nucleoside base, a blocked nucleoside base, a nucleoside base analog, or a blocked nucleoside base analog; and L is a leaving group or together L and Bx are a 2-3â€² or 6-3â€² pyrimidine or 8-3â€² purine cyclo-nucleoside.