Patent ID: 8008263
Filing Date: 2011-08-30
Classification: A61P,C07D,C07K

Abstract:
1. A compound of the Formula I: and pharmaceutically acceptable salts and stereoisomers thereof; wherein X is absent or selected from NR i and k are independently selected integers selected from the group consisting of 0, 1, 2, 3 and 4; j is an integer selected from the group consisting of 1, 2, 3 and 4, wherein the sum of i+j+k is less than or equal to 5 and greater than or equal to 2 when X is absent and the sum of i+j+k is less than or equal to 4 and greater than or equal to 1 when X is oxygen; p is 0, 1, 2 or 3; E is OH, NH R R R R R R each independently selected at each occurrence from the group consisting of halogen, hydroxy, amino, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, mono- and di-C 1-4 alkylamino, hydroxyC 1-4 alkyl, and C 1-4 alkoxyC 1-4 alkyl; R R