Patent ID: 8987238
Filing Date: 2015-03-24
Classification: A61K,A61P

Abstract:
1. A method of treating menopause-related symptoms comprising administering once daily an effective amount of a pharmaceutical composition to a subject in need thereof, the pharmaceutical composition comprising: about 50 mg progesterone; about 0.50 mg estradiol or about 0.52 mg estradiol hemihydrate, wherein at least about 90% of the estradiol or the estradiol hemihydrate is solubilized; about 97.98 mg of a solubilizing agent comprising monoglycerides and diglycerides of caprylic acid and capric acid (CAPMUL MCM); and about 1.50 mg of at least one of lauroyl macrogol-32 glycerides EP, lauroyl polyoxyl-32 glycerides NF, or lauroyl polyoxylglycerides (GELUCIRE 44/14); wherein the estradiol or the estradiol hemihydrate, and the progesterone are uniformly dispersed in the solubilizing agent.