Patent ID: 6706702
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A compound of the formula wherein Z is CH2, C(&boxH;O) or CF2; R1 is hydrogen, (C1-C6)alkyl, unconjugated (C3-C6)alkenyl, benzyl, XC(&boxH;O)R13 or â€”CH2CH2â€”Oâ€”(C1-C4)alkyl; R2 and R3, together with the carbons to which they are attached, form a five membered heterocyclic ring wherein from two to three of the nonfused atoms of said five membered ring may independently be nitrogen, oxygen or sulfur, and wherein said heterocyclic ring may optionally be substituted with one or more substituents, that are selected, independently, from (C0-C6) alkoxy-(C1-C6)alkyl- or (C1-C6) alkoxy-(C0-C6)alkyl- wherein the total number of carbon atoms does not exceed six and wherein any of the alkyl moieties may optionally be substituted with from one to seven fluorine atoms; nitro, oxo, cyano, halo, hydroxy, amino, (C1-C6)alkylamino, [(C1-C6) alkyl]2amino, phenyl and monocyclic heteroaryl wherein said heteroaryl is selected from five to seven membered aromatic rings containing from one to four heteroatoms selected from oxygen, nitrogen and sulfur; R13 is selected, independently, from hydrogen and (C1-C6) alkyl; and each X is, independently, (C1-C6)alkylene; with the proviso that: no fluorine atom in any of the fluoro substituted alkyl or alkoxy moieties of R2 and R3 can be attached to a carbon that is attached to a heteroatom; or a pharmaceutically acceptable salt thereof.