Patent ID: 8962697
Filing Date: 2015-02-24
Classification: A61K,A61P,C08L

Abstract:
1. A polymer of formula II: wherein (i) each Bio is, independently, one or more biologically active agents, or precursors thereof, tethered to polyamide linker P through hydrolysable covalent bonds; (ii) each P is a polyamide linker susceptible to hydrolysis by a peptidase enzyme and tethered to said Bio and C1; and (iii) C1 is a coupling segment linking P to Oligo, wherein C1 is formed from a silicone diol; (iv) C2 is a polyamide linker susceptible to hydrolysis by a peptidase enzyme linking Bio to Bio; (v) Oligo is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; wherein each of n, o, and p is independently an integer greater than 0; and m is an integer 0 or 1; wherein said polyamide linker comprises an amino acid sequence selected from the group consisting of: