Patent ID: 8617818
Filing Date: 2013-12-31
Classification: A61P,C12Q,G01N

Abstract:
1. A method for prognosing or diagnosing a potential cancer and progression of an existing cancer in a patient by analyzing Akt isoform imbalance, wherein the imbalance comprises a decreased ratio of Akt1 protein to Akt2 protein compared to that ratio in a normal subject, the method comprising: measuring an expression profile of a plurality of microRNA (miRNA) species regulated by Akt isoform expression in a sample from the patient, by real-time PCR, or by using an array of miRNA nucleotide sequences of a plurality of miRNA species each sequence at a known location on a substrate; and comparing the profile from the patient with that of the normal subject not having the cancer and obtaining an miRNA tumor expression profile; wherein the decreased ratio of the Akt isoform expression profile of the sample from the patient compared to the normal subject is a prognosis or diagnosis of the potential cancer or an indication of the progression of the existing cancer in the patient.