Patent ID: 7592457
Filing Date: 2009-09-22
Classification: A61P,C07C,C07D

Abstract:
1. A compound of 3-aryl-3-methyl-quinoline-2,4-dione-selected from the group consisting of: 5,7-dichloro-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 7-chloro-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5,7-dibromo-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5-chloro-7-methoxy-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 7-chloro-5-methoxy-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5-bromo-7-methoxy-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5,7-dimethoxy-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 6,7-dichloro-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 6,8-dibromo-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5-chloro-7-dimethylamino-3-methyl-3-phenyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-methoxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-hydroxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-methyl-3-(4-nitro-phenyl)-1H-quinoline-2,4-dione; 3-(4-amino-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-iodo-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-chloro-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(4-bromo-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-(3-benzyloxy-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-(3-hydroxy-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-methoxy-3-nitro-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-hydroxy-3-nitro-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(4-benzyloxy-3-bromo-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-(3-bromo-4-hydroxy-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-[4-(1(S)-phenyl-ethyl-carbamoyl)-phenyl]-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-[3-(1(S)-phenyl-ethyl-carbamoyl)-phenyl]-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 3-(2,4-dibromo-phenyl)-5,7-dichloro-3-methyl-1H-quinoline-2,4-dione; 6,8-dibromo-3-(4-methoxy-3-nitro-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(3-amino-4-methoxy-phenyl)-6,8-dibromo-3-methyl-1H-quinoline-2,4-dione; 3-(3-amino-4-hydroxy-phenyl)-6,8-dibromo-3-methyl-1H-quinoline-2,4-dione; 3-(4-hydroxy-3-methoxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(3,4-dihydroxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(4-methoxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 3-(4-hydroxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5-chloro-7-methoxy-3-(4-methoxy-phenyl)-3-methyl-1H-quinoline-2,4-dione; 6,7-dichloro-3-methyl-3-(4-nitro-phenyl)-1H-quinoline-2,4-dione; 7-chloro-3-methyl-3-(4-nitro-phenyl)-1H-quinoline-2,4-dione; 3-(4-amino-phenyl)-7-chloro-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-methyl-3-(4-methylamino-phenyl)-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-dimethylamino-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5,7-dichloro-3-methyl-3-(4-ethylamino-phenyl)-1H-quinoline-2,4-dione; 5,7-dichloro-3-(4-diethylamino-phenyl)-3-methyl-1H-quinoline-2,4-dione; 1-(R)-[3-(5,7-dichloro-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinoline-3-yl)-phenyl]-3-(1-(S)-phenyl-ethyl)-urea; 1-(S)-[3-(5,7-dichloro-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinoline-3-yl)-phenyl]-3-(1-(S)-phenyl-ethyl)-urea; 7-chloro-3-(2,4-dibromo-phenyl)-3-methyl-1H-quinoline-2,4-dione; 5-chloro-3-(4-methoxy-phenyl)-3-methyl-7-(4-methyl-piperazine-1-yl)-1H-quinoline-2,4-dione; 5-chloro-3-(4-hydroxy-phenyl)-3-methyl-7-(4-methyl-piperazine-1-yl)-1H-quinoline-2,4-dione; 3-(4-amino-phenyl)-5-chloro-3-methyl-7-(4-methyl-piperazine-1-yl)-1H-quinoline-2,4-dione; 5-chloro-3-methyl-7-(4-methyl-piperazine-1-yl)-3-(4-nitro-phenyl)-1H-quinoline-2,4-dione; 3-(4-amino-phenyl)-3-methyl-7-(4-methyl-piperazine-1-yl)-1H-quinoline-2,4-dione; 3-methyl-7-(4-methyl-piperazine-1-yl)-3-(4-nitro-phenyl)-1H-quinoline-2,4-dione; and 3-(4-bromo-phenyl)-5-chloro-7-methoxy-3-methyl-1H-quinoline-2,4-dione.