Patent ID: 6458775
Filing Date: 2002-10-01
Classification: A61P,C07C,C07D

Abstract:
A method for inhibiting NAALADase enzyme activity in a mammal in need thereof, comprising administering to said mammal an effective amount of a compound of formula I or a pharmaceutically acceptable equivalent, wherein:X is a moiety of formula II, III or IV m and n are independently 0, 1, 2, 3 or 4; Z is SR13, SO3R13, SO2R13, SOR13, SO(NR13)R14 or S(NR13R14)2R15; B is N or CR16; A is O, S, CR17R18 or (CR17R18)mS; R9 and R13 are hydrogen; R8, R10, R11, R12 , R14, R15, R16, R17 and R18 are independently hydrogen, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, Ar1, hydroxy, carboxy, carbonyl, amino, amido, cyano, isocyano, nitro, sulfonyl, sulfoxy, thio, thiocarbonyl, thiocyano, formanilido, thioformamido, sulfhydryl, halo, haloalkyl, trifluoromethyl or oxy, wherein said alkyl, alkenyl, cycloalkyl and cycloalkenyl are independently unsubstituted or substituted with one or more substituent(s); and Ar1 is a carbocyclic or heterocyclic moiety, which is unsubstituted or substituted with one or more substituent (s) provided that when X is a moiety of formula II and A is O, then n is 2, 3 or 4; when X is a moiety of formula II and A is S, then n is 2, 3 or 4; and when X is a moiety of formula II and A is (CR17R18)mS, then n is 0, 2, 3 or 4.