Patent ID: 6486184
Filing Date: 2002-11-26
Classification: A61P,C07C,C07D

Abstract:
An amide selected from the group consisting of a compound of the formula: wherein R1 and R2 are independently hydrogen, halo, cyano, nitro, lower alkylthio, perfluoro loweralkylthio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R3 a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur; R6is an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; with said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, â€”(CH2)nâ€”OR9, â€”(CH2)nâ€”C(O)â€”OR10, â€”(CH2)nâ€”C(O)â€”NHâ€”R11, â€”C(O)â€”C(O)â€”OR12, â€”(CH2)nâ€”NHR13; n is 0, 1, 2, 3 or 4; R7, R8, R9, R10, R11, R12and R13 are independently hydrogen or lower alkyl; X is oxygen, sulfur, sulfonyl or carbonyl; the * indicates an asymmetric carbon atom; and its pharmaceutically acceptable salts.