Patent ID: 6689794
Filing Date: 2004-02-10
Classification: A61K,A61P,C04B,C07D,Y02A

Abstract:
A compound or salt thereof, wherein: the compound corresponds in structure to Formula 122-1: â€ƒand A1 is selected from the group consisting of â€”H, alkylcarbonyl, alkoxycarbonyl, carbocyclylcarbonyl, carbocyclylalkylcarbonyl, heterocyclylcarbonyl, heterocyclylalkylcarbonyl, carbocyclyloxycarbonyl, carbocyclylalkoxycarbonyl, aminoalkylcarbonyl, alkyl(thiocarbonyl), alkoxy(thiocarbonyl), carbocyclyl(thiocarbonyl), carbocyclylalkyl(thiocarbonyl), heterocyclyl(thiocarbonyl), heterocyclylalkyl(thiocarbonyl), carbocyclyloxy(thiocarbonyl), carbocyclylalkoxy(thiocarbonyl), and aminoalkyl(thiocarbonyl), wherein any member of such group optionally is substituted; and A2 and A3, together with the carbon atom to which they are both attached, form an optionally-substituted heterocyclyl containing from 5 to 8 ring members; and E1 is selected from the group consisting of â€”Oâ€”, â€”S(O)2â€”, and â€”S(O)â€”; and E2 is alkyl, wherein the alkyl optionally is substituted; and E2 forms a link of at least 2 carbon atoms between E1 and E3; and E3 is heterocyclyl, wherein the heterocyclyl has 5 or 6 ring members and optionally is substituted; and E4 is selected from the group consisting of a bond, alkyl, alkenyl, â€”Oâ€”, and, â€”N(R3)â€”, wherein the alkyl or alkenyl optionally is substituted; and E5 is selected from the group consisting of carbocyclyl and heterocyclyl, wherein the carbocyclyl or heterocyclyl optionally is substituted; and R3 is selected from the group consisting of â€”H and alkyl, wherein the alkyl optionally is substituted.