Patent ID: 6685954
Filing Date: 2004-02-03
Classification: A01N,A61P,Y10S

Abstract:
A synergistic spot-on composition for the long lasting protection against ectoparasites on mammals which comprises synergistic amounts(A) at least one compound of the formula: in which:R1 is CN or methyl or a halogen atom; R2 is S(O)nR3 or 4,5-dicyanoimidazol-2-yl or haloalkyl; R3 is alkyl or haloalkyl; R4 represents a hydrogen or halogen atom; or a radical NR5R6, S(O)mR7, C(O)R7, C(O)Oâ€”R7, alkyl, haloalkyl, or OR8 or a radical â€”N&boxH;C(R9)(R10); R5 and R6 independently represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl, alkoxycarbonyl or S(O)râ€”CF3 radical; R5 and R6 may together form a divalent alkylene radical which may be interrupted by one or two divalent hereto atoms or; R7 represents an alkyl or haloalkyl radical; R8 represents an alkyl or haloalkyl radical or a hydrogen atom; R9 represents an alkyl radical or a hydrogen atom; R10 represents a phenyl or heteroaryl group optionally substituted with one or more halogen atoms or one or more substituents selected from the group consisting of OH, â€”O-alkyl, S-alkyl, cyano or alkyl; R11 and R12 represent, independently of each other, hydrogen, halogen, CN or NO2; R13 represents a halogen atom or a haloalkyl, haloalkoxy, S(O)qCF3 or SF5 group; m, n, q and r represent, independently of each other, an integer equal to 0, 1 or 2; X represents a trivalent nitrogen atom or a radical Câ€”R12, the other three valency positions of the carbon atom forming part of the aromatic ring; with the proviso that when R1 is methyl, then R3 is haloalkyl, R4 is NH2, R11 is Cl, R13 is CF3 and X is N; or R2 is 4,5-dicyanoimidazol-2-yl, R4 is Cl, R11, is Cl, R13 is CF3 and X is &boxH;Câ€”Cl; (B) at least one insect growth regulator (IGR) that mimics juvinile hormones; (C) imidacloprid; and a fluid vehicle comprising at least one customary spot-on formulation adjuvant.