Patent ID: 6362189
Filing Date: 2002-03-26
Classification: C07D

Abstract:
A compound of formula I or pharmaceutical acceptable salts thereof wherein:G is R1 is a) H, b) NH2, c) NHâ€”C1-4 alkyl, d) C1-4 alkyl, e) â€”OC1-4 alkyl, f) â€”S C1-4 alkyl, g) C1-4 alkyl substituted with 1-3 F, 1-2 Cl, CN or â€”COOC1-4 alkyl, h) C3-6 cycloalkyl, i) N(C1-4) alkyl)2 or j) N(CH2)2-5; A is wherein R23 and R24 are independently a) H, b) F, c) Cl, d) C1-2 alkyl, e) CN f) OH, g) C1-2 alkoxy, h) nitro, or i) amino; Q is wherein Z2 is â€”N(R107)â€”, wherein R102 is a) Hâ€”, b) CH3â€”, c) phenyl-CH2â€”, or d) CH3C(O)â€”; wherein R103 is a) (C1-C3)alkyl-, or b) phenyl-; wherein R107 is a) R102Oâ€”C(R110)(R111)â€”C(O)â€”, b) R103Oâ€”C(O)â€”, c) R108â€”C(O)â€”, f) H3Câ€”C(O)â€”(CH2)2â€”C(O)â€”, g) R109â€”SO2â€”, i) HOâ€”CH2â€”C(O)â€”, j) R116â€”(CH2)2â€”, k) R113â€”C(O)â€”Oâ€”CH2â€”C(O)â€”, l) (CH3)2Nâ€”CH2â€”C(O)â€”NHâ€”, m) NCâ€”CH2â€”, n) F2â€”CHâ€”CH2â€”, or o) R150R151NSO2â€”; wherein R108 is a) Hâ€”, b) (C1-C4)alkyl, c) aryl â€”-(CH2)p, d) ClH2Câ€”, e) Cl2HCâ€”, f) FH2Câ€”, g) F2HCâ€”, h) (C3-C6)cycloalkyl; or i) CNCH2â€”; wherein R109 is a) (C1-C4)alkyl, b) â€”CH2Cl c) â€”CH2CH&boxH;CH2, d) aryl, or e) â€”CH2CN; wherein R110 and R111 are independently a) Hâ€”, b) CH3â€”; or wherein R113 is a) CH3â€”, b) HOCH2â€”, c) (CH3)2N-phenyl, or d) (CH3)2Nâ€”CH2â€”; wherein R116 is a) HOâ€”b) CH3Oâ€”, or c) F; wherein R150 and R151 are each H or C1-C4alkyl, or R150 and R151 taken together with the nitrogen atom to which each is attached form a monocyclic heterocyclic ring having from 3 to 6 carbon atoms; p is 0, 1, 2, 3, 4, or 5; and w is 0, 1, 2 or 3.