Patent ID: 8383643
Filing Date: 2013-02-26
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein Z is independently selected from the group consisting of: S, S(O), S(O) B is a 5 membered heteroaryl ring containing 1, 2 or 3 heteroatoms selected from NH, O and S, wherein any CH is unsubstituted or substituted with one substituent selected from R each R each R wherein CH each R wherein alkyl is unsubstituted or substituted with hydroxy or one to three halogens, and wherein any CH R each R each R wherein alkyl is unsubstituted or substituted with one to five fluorines; each R wherein any CH each R wherein any CH each R wherein alkyl is unsubstituted or substituted with one to three substituents independently selected from the group consisting of: halogen, cyano, —C each R wherein CH each R m is an integer from 1 to 3; n is an integer from 0 to 3; p is an integer from 1 to 3; q is an integer from 1 to 2; r is an integer from 0 to 2; s is an integer from 0 to 4; t is an integer from 0 to 8; d is an integer from 0 to 2; and e is an integer from 0 to 2, provided that d+e is 2.