Patent ID: 6423666
Filing Date: 2002-07-23
Classification: B01J,C08F,G01N

Abstract:
A process for the preparation of a chromatographic separation medium in the form of beads having through-pores with diameters of at least about 0.5 micron, said process comprising:(a) forming a suspension of aqueous liquid droplets in an organic continuous phase, said aqueous liquid comprising a monomer mixture dissolved in water, said monomer mixture consisting of water-soluble polymerizable compound and water-soluble crosslinking agent, in which the weight percent of said monomer mixture relative to said aqueous liquid is from about 2% to about 50% and the mole fraction of said crosslinking agent relative to said monomer mixture is from about 0.1 to about 0.7, and said organic continuous phase comprising an organic solvent with an emulsifying agent dissolved therein, said organic solvent being at least partially immiscible with water; (b) polymerizing said droplets to form solid porous beads having through-pores with diameters of from at least about 0.5 micron; and (c) recovering said solid porous beads from said organic continuous phase.