Patent ID: 9200281
Filing Date: 2015-12-01
Classification: A61K,A61P,C12N

Abstract:
1. A method for inhibiting expression of a polynucleotide sequence of hepatitis B virus in an in vivo mammalian cell comprising administering to said cell a double-stranded RNA effector molecule said double-stranded RNA effector molecule: (1) comprising: (a) a sequence selected from the group consisting of SEQ ID NO:57, SEQ ID NO: 56, and SEQ ID NO: 60; (b) the reverse complement of said selected sequence; wherein U is substituted for T; or (2) consisting of: (a) a sequence selected from SEQ ID NO: 54 or SEQ ID NO: 55, and (b) the reverse complement of said selected sequence; wherein U is substituted for T.