Patent ID: 7166279
Filing Date: 2007-01-23
Classification: A61K,A61P,C12N

Abstract:
1. A method of supplying to the central nervous system of a human patient a peptide that binds an opioid receptor, comprising: (a) obtaining autologous muscle cells from the patient and preparing a pure in vitro culture of myoblasts; (b) transducing the culture of (a) with DNA encoding the peptide, such that the myoblasts express the peptide, then (c) introducing the transduced myoblasts as a suspension to a muscle of the same human patient in a form that allows fusion with and intracellular expression of the peptide in pre-existing muscle cells of the human patient, the muscle selected from the group consisting of a paraspinal muscle, levator scapulae muscle, muscle between laminae IV and V of the spinal cord and neck muscle, so that the peptide is produced in proximity to the spinal cord of the patient.