Patent ID: 6471954
Filing Date: 2002-10-29
Classification: A61K,A61P,A61Q

Abstract:
A method for producing a vitamin A-containing cream, the method comprising the steps of(a) preparing a first mixture by combining at least one water soluble substance selected from glycerine, EDTA and sodium lactate, and extracts of plants during heating and comminuting until the mixture has a temperature of about 80-83Â° C.; (b) preparing a second mixture by mixing emulsifiers, squalane, and at least one vegetable oil during heating until the mixture has a temperature of about 80-83Â° C.; (c) preparing a third mixture by gradually adding the first mixture of step (a) to the second mixture of step (b) during high-shear mixing with a decreasing number of revolutions from about 5000 rpm to about 3000 rpm and while allowing the mixture to cool to a temperature of about 50-51Â° C.; (d) preparing a fourth mixture by combining alpha-tocopherol, tocopherol acetate, retinyl palmitate and retinyl acetate; (e) adding the fourth mixture of step (d) to the third mixture of step (c) to create a fifth mixture; (f) homogenizing the fifth mixture of step (e) at a pressure of about 1000 bar and at a temperature of about 50Â° C.; (g) subjecting the homogenized mixture of step (f) to high-shear-mixing with a decreasing number of revolutions while allowing the homogenized mixture to cool to a temperature of about 40-45Â° C. to create a cream; and (h) adjusting the viscosity of the cream by stirring.