Patent ID: 6770745
Filing Date: 2004-08-03
Classification: A61K,C07K

Abstract:
A pharmaceutical composition which comprises an effective amount of a gamma common chain blocking agent wherein the agent is a monoclonal antibody selected from the group consisting of:(a) a monoclonal antibody that cross competes with monoclonal antibody CP.B8 produced by hybridoma cell line ATCC No. HB-12107 for binding to gc chain, and also cross competes with Fab, F(abâ€²)2, and Fv fragments and conjugates of said CP.B8; (b) a monoclonal antibody that cross competes with monoclonal antibody CQ.C11 produced by hybridoma cell line ATCC No. HB-12105 for binding to gc chain, and also cross competes with Fab, F(abâ€²)2, and Fv fragments and conjugates of said CQ.C11; (c) a monoclonal antibody that cross competes with monoclonal antibody AF.F4 produced by hybridoma cell line ATCC No. HB-12104 for binding to gc chain, and cross competes Fab, F(abâ€²)2, and Fv fragments and conjugates of said AF.F4; and (d) a monoclonal antibody that cross competes with the monoclonal antibody AE.C9 produced by hybridoma cell line ATCC No. HB-12106 for binding to gc chain, and cross competes with Fab. F(abâ€²)2, and Fv fragments and conjugates of said AE.C9.