Patent ID: 6380170
Filing Date: 2002-04-30
Classification: A61K,A61P,C07K,C12N

Abstract:
A nucleic acid construct comprising:(a) at least one activator sequence; (b) at least one chimeric promoter module comprising a nucleotide sequence selected from the group consisiting of (SEQ ID NO: 1) ACTTGGCGGGAGATTTGAAT and (SEQ ID NO: 2) GCTTGGCGGGAGGTTTGAAT which binds a protein of the E2F family and binds a CDF-1 protein, wherein said activator sequence is upstream of said chimeric promoter module; and (c) at least one gene, wherein said chimeric promoter module promotes expression of said gene occurring later in a cell cycle than the regulation by a B-myb promoter but earlier than regulation by a cdc25C promoter.