Patent ID: 6166199
Filing Date: 2000-12-26
Classification: A61K,A61P,C07H,C07J,C12N,C12Q,C12Y

Abstract:
A method for the preparation of a compound of Formula I: ##STR7## wherein G is CH or N;X is NH.sub.2 or OH;Y is RQ or NHRQ, wherein said R is a hydrocarbyl group having from 2 to about 20 carbon atoms; and Q is H, NH.sub.2, polyalkylamino, hydrazines, hydroxylamines, semicarbazides, thiosemicarbazides, hydrazones, hydrazides, imidazoles, imidazole amides, alkylimidazoles, tetrazole, triazole, pyrrolidine, piperidine, piperazine, morpholine, thiols, aldehydes, ketones, alcohols, alkoxy groups, or halogens or alkoxy groups; andZ is H, ribose or deoxyribose; comprising:providing a compound of Formula I wherein Y is halogen; andcontacting said compound with a compound of Formula RQ or NHRQ, wherein R is a hydrocarbyl group having from 2 to about 20 carbon atoms; and Q is H, NH.sub.2, polyalkylamino, a hydrazine, a hydroxylamine, a semicarbazide, a thiosemicarbazide, a hydrazone, a hydrazide, an imidazole, an imidazole amide, an alkylimidazole, a tetrazole, a triazole, a pyrrolidine, a piperidine, a piperazine, a morpholine, a thiol, an aldehyde, a ketone, an alcohol, or an alkoxy group;under conditions of time, temperature and pressure sufficient to form said compound of Formula I.