Patent ID: 8563570
Filing Date: 2013-10-22
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: Cy is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 —W—X—Y—Z; L is (CR Q is —(CR A is cycloalkyl or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 —W′—X′—Y′—Z′; E is —(CR D R R R R or R or R or R or R or R or R or R or R or R or R R R R R W, W′ and W″ are each, independently, absent, C X, X′ and X″ are each, independently, absent, C Y, Y′ and Y″ are each, independently, absent, C Z, Z′ and Z″ are each, independently, H, halo, CN, NO wherein two —W—X—Y—Z attached to the same atom optionally form a 3-20 membered cycloalkyl or heterocyloalkyl group, each optionally substituted by 1, 2 or 3 —W″—X″—Y″—Z″; wherein two —W′—X′—Y′—Z′ attached to the same atom optionally form a 3-20 membered cycloalkyl or heterocyloalkyl group, each optionally substituted by 1, 2 or 3 —W″—X″—Y″—Z″; wherein —W—X—Y—Z is other than H; wherein —W′—X′—Y′—Z′ is other than H; wherein —W″—X″—Y″—Z″ is other than H; R R R or R R or R R or R R or R m is 0, 1, 2 or 3; n1 is 1, 2, 3 or 4; n2 is 0, 1, 2, 3 or 4; n3 is 0, 1, 2, 3 or 4; p is 0, 1 or 2; q1 is 0, 1 or 2; q2 is 0, 1 or 2; and r is 0, 1 or 2; with the proviso: when Cy is aryl optionally substituted with 1, 2, 3, 4 or 5 —W—X—Y—Z or heteroaryl optionally substituted with 1, 2, 3, 4 or 5 —W—X—Y—Z; L is SO