Patent ID: 9149486
Filing Date: 2015-10-06
Classification: A61K,A61P

Abstract:
1. A method of treating a middle ear infection in a human patient comprising the steps of: (a) diagnosing the patient as having otitis media and an open tympanic membrane in at least one ear; and (b) topically applying into the ear canal of the patient's ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprises a) 0.01-0.5% (wt.) dexamethasone, wherein the dexamethasone has an average particle size on a mean volume basis of less than 10 μM; b) 0.1-0.4% (wt.) ciprofloxacin; c) 0.1-0.9% (wt.) tonicity agent; d) 0.01-0.2% (wt.) of a nonionic surfactant; e) a buffer; and wherein the composition has a pH from about 3-5.