Patent ID: 8318164
Filing Date: 2012-11-27
Classification: A61K,A61P,C07K

Abstract:
1. A stable formulation, comprising: (a) a humanized 3D6 antibody or antigen binding fragment thereof at a concentration of from 1 mg/ml to 100 mg/ml, wherein the humanized antibody or antigen binding fragment comprises a light chain variable region having an amino acid sequence as set forth in residues 1-112 of SEQ ID NO:1 and a heavy chain variable region having an amino acid sequence as set forth in residues 1-119 of SEQ ID NO:2; (b) histidine at a concentration of from 5 mM to 15 mM; (c) mannitol in an amount of from 2% w/v to 6% w/v; (d) methionine at a concentration of from 5 mM to 15 mM; and (e) polysorbate in an amount of from 0.001% w/v to 0.01% w/v, wherein the formulation has a pH of from 5.5 to 6.5.