Patent ID: 6316635
Filing Date: 2001-11-13
Classification: A61K,C07D

Abstract:
A 2-indolinone having the chemical structure: ##STR15##or a physiologically acceptable salt thereof, wherein:G and J are selected from the group consisting of nitrogen and carbon such that, when G is nitrogen, J is carbon and when J is nitrogen, G is carbon, it being recognized that, when G or J is nitrogen, R.sub.5 or R.sub.5', respectively, does not exist;R.sub.1, R.sub.2 and R.sub.3 are each hydrogen;R.sub.4, R.sub.5 and R.sub.5' are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroawyl, heteroalicylic, halo, hydroxy, nitro, cyano, alkoxy, aryloxy, --C(O)OR"", --OC(O)R"", --C(O)R"", S-sulfonamido, amino and NR.sub.10 R.sub.11 whereinR.sub.10 and R.sub.11 are independently selected from the group consisting of alkyl, cycloalkyl, aryl, --C(O)R"", --S(O).sub.2 R"", tri-halomethanesulfonyl and, combined, a five-member or a six-member heteroalicyclic ring;R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, --S(O)R"", --S(O).sub.2 R"", S-sulfonamido, N-sulfonamido, N-trihalomethanesulfonamido, --C(O))OR"", --OC(O)R"", --C(O)R"", cyano, halo, cyanato, isocyanato, thiocyanato, isothiocyanato, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, ainio and --NR.sub.10 R.sub.11 with R.sub.10 and R.sub.11 as defined above;R.sub.6 and R.sub.7 or R.sub.7 and R.sub.8 or R.sub.8 and R.sub.9, combined, may form a five- or six-member aromatic, heteroaromatic, alicyclic or heteroalicyclic ring group; andR"" is selected from the group consisting of hydrogen, alky, cycloalkyl and heteroaryl bonded through a ring carbon;with the proviso that the following compounds are excluded:3[(1-methyl-5-nitro-imidazol-2-yl)methlene]-2-indolinone;1H-indole-7-acetic acid 3-[(2-butyl-1H-imidazol-4-yl)methylene]-2.3-dihydro-2-oxo ethyl ester; and1H-indole-7-acetic acid 3-[(2-butyl-1-[1,1-dimethylethoxy)carbonyl]-1H-imidazol-4-yl) methylene]-2,3-dihydro-2-oxo ethyl ester.