Patent ID: 8865158
Filing Date: 2014-10-21
Classification: A61K,A61P,C12N

Abstract:
1. A genetically modified bacteriophage comprising: (i) an exogenous polynucleotide which encodes at least one agent which reduces the toxicity of a bacterium, is non-toxic to the bacterium and does not affect directly the survival of said bacterium, said polynucleotide is a dominant sensitive antibiotic resistant gene that reverses resistance of said bacterium to an antibiotic, wherein said at least one agent is 30S ribosomal subunit protein S12, encoded by the polynucleotide sequence of SEQ ID NO: 24; and (ii) an exogenous polynucleotide which encodes a selectable marker that renders a bacterium infected by said phage resistant to a toxic compound selected from the group consisting of potassium-tellurite, chlorhexidine salts, diamidines, acridines, arsenite, arsenate and antimonite.