Patent ID: 7687630
Filing Date: 2010-03-30
Classification: C07D

Abstract:
1. A method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position comprising reacting 3-quinuclidinones having one or more substituted groups at the 2-position with compounds selected from alcohol compounds having a hydrogen atom at the α-position, formic acid and formates in the presence of a metal complex represented by the general formula (1) (wherein, R 1 and R 2 are both simultaneously or each independently alkyl groups, phenyl groups, naphthyl groups or cycloalkyl groups which may have one or more substituted groups, optionally, R 1 and R 2 may also join to form an alicyclic ring, R 3 is an alkyl group, perfluoroalkyl group, naphthyl group, phenyl group or camphor which may have one or more substituted groups, R 4 is a hydrogen atom or an alkyl group, Ar, joined to M via a π bond, is a benzene ring which may have one or more substituted groups or a cyclopentadienyl group which may have one or more substituted groups, X is a hydride group or an anionic group, M is ruthenium, rhodium or iridium, * represents an asymmetric carbon atom).