Patent ID: 6225494
Filing Date: 2001-05-01
Classification: A61P,C07C

Abstract:
A compound of the formula ##STR15##where X is O, S, C(R.sub.2).sub.2 or NOR*,R* is H, C.sub.1-6 alkyl or phenyl;R.sub.1 is H, lower alkyl of 1 to 10 carbons, F, Cl, Br, I, CF.sub.3, OR.sub.2 SR.sub.2, OCH.sub.2 OC.sub.1-6 alkyl or CF.sub.2 CF.sub.3 ;R.sub.2 is independently H, lower alkyl of 1 to 10 carbons, R.sub.3 Si, or COR.sub.3 where R.sub.3 is H, lower alkyl of 1 to 6 carbons or phenyl;R.sub.4 is lower alkyl of 1 to 6 carbons, F, Cl, Br, I, CF.sub.3, CF.sub.2 CF.sub.3, NO.sub.2, N(R.sub.6).sub.2, CNCOR.sub.3, or N(R.sub.6)--COR.sub.3 ;m is an integer between 0 and 3;Y.sub.1 is phenyl, naphthyl or heteroaryl selected from a group consisting of pyridyl, thienyl, fluryl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl, naphthyl and heteroaryl groups being unsubstituted or substituted with one to three R.sub.5 groups, where R.sub.5 is alkyl of 1 to 10 carbons, fluoro-substituted alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons and having 1 to 3 double bonds, alkynyl having 2 to 10 carbons and 1 to 3 triple bonds, F, Cl, Br, I, NO.sub.2, CN, COOH, COOC.sub.1-6 alkyl; N.sub.3 ; N(R.sub.6).sub.2, OH, OR.sub.3 ; SR.sub.3 ; OCOR.sub.3, or SCOR.sub.3 ;Z is --C.tbd.C----N.dbd.N--,--N(O).dbd.N--,--N.dbd.N(O)--,--N.dbd.CR.sub.6 --,--CR.sub.6.dbd.N,--(CR.sub.6.dbd.CR.sub.6).sub.n -- where n is an integer having the value 0-5,--CO--NR.sub.6 --,--CS--NR.sub.6 --,--NR.sub.6 --CO,--NR.sub.6 --CS,--COO--,--OCO--;--CSO--;--OCS--;--CO--CR.sub.6.dbd.CR.sub.6 --R.sub.6 is independently H or lower alkyl of 1 to 6 carbons;Y.sub.2 is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being unsubstituted or substituted with one or two R.sub.4 groups, orwhen Z is --(CR.sub.6.dbd.CR.sub.6).sub.n and n is 3, 4 or 5 then Y.sub.2 represents a direct valence bond between said (CR.sub.6.dbd.CR.sub.6).sub.n group and B;Y.sub.3 is phenyl, pyridyl, thienyl or funyl unsubstituted or substituted with up to 3 R.sub.1 groups and unsubstituted or substituted with up to 3 R.sub.4 groups;A is (CH.sub.2).sub.q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds;B is hydrogen, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CH(OR.sub.13 O), --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 (OR.sub.13 O), or Si(C.sub.1-6 alkyl).sub.3, where R.sub.7 is an alkyl, cycloakyl or alkenyl group containing 1 to 5 carbons, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl, hydroxyphenyl or lower alkylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons.