Patent ID: 6166013
Filing Date: 2000-12-26
Classification: C07C,C07D

Abstract:
A method of selectively modulating the glucocorticoid receptor-mediated gene expression in a mammal comprising administering an effective amount of a compound of Formula I ##STR8## or a pharmaceutically acceptable salt or prodrug thereof, where R.sup.1 is hydrogen;L.sup.1 is a covalent bond;R.sup.2 and R.sup.3 are independently selected from(1) hydrogen, and(2) alkyl of one to six carbons;R.sup.4 and R.sup.5 are independently selected from(1) hydrogen, and(2) NR.sup.12 R.sup.13, where R.sup.12 and R.sup.13 are independently selected from(a) hydrogen,(b) an amino-protecting group,(c) alkyl of one to six carbons, and(d) alkyl of one to six carbons substituted with 1, 2, or 3 substituents independently selected from(i) --OR.sup.10, where R.sup.10 is selected from(aa) hydrogen,(bb) alkyl of one to six carbons,(cc) a hydroxy-protecting group, and(dd) --C(O)R.sup.11 where R.sup.11 is selected from alkyl of one to six carbons, phenyl, and phenyl substituted with 1, 2, or 3 substituents independently selected from --NO.sub.2, alkyl of one to six carbons, and halogen; and(ii) phenyl, orR.sup.12 and R.sup.13 together with the nitrogen to which they are attached for a 4 to 8 membered ring selected from the group consisting of heterocycle; andR.sup.6, R.sup.7, and R.sup.8 are independently selected from(1) hydrogen,(2) halogen, and(3) --NO.sub.2.