Patent ID: 8258148
Filing Date: 2012-09-04
Classification: A61K,A61P,C07D

Abstract:
1. A method of modulating activity of an M 1 or M 4 muscarinic receptor, comprising the step of contacting said receptor with a compound of formula (I) or pharmaceutically acceptable salts thereof, wherein Each of R Z Z L is a bond, an aliphatic group, C G is a monocycloheteroaliphatic group, selected from pyrrolidine, piperidine and azepane, or G is an adamantyl, or a bicyclic or a tricyclic group of the formula (III) in which the monocycloheteroaliphatic group, the adamantyl, and the bicyclic or tricyclic group are connected to L via any ring atom including those in X Bond r is a single or double bond and when ring B is present, bond r is fused with B; Ring B, when present, is a 5-6 membered cycloaliphatic or heterocycloaliphatic ring, and is optionally substituted with 1-3 of oxo, Q X Each Q Each Q Each Q Each Q Each Q Each i is independently 1, 2, or 3; Each m and n is 2; Each p is 0; Each y is independently 0 or 1; Each t is 1 to 4; and Each z is independently 0, 1, or 2.