Patent ID: 6107271
Filing Date: 2000-08-22
Classification: A61K,A61P,C07K

Abstract:
A method for effecting at least the same biological activity of an N-methyl D-aspartate receptor as the binding of glycine, comprising contacting said N-methyl D-aspartate receptor with a polypeptide or amino acid composition selected from the group consisting of:Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr (SEQ ID No:3);Val-Tyr-Tyr-Ser-Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr (SEQ ID No: 4);Glu-Asp-Leu-Ala-Val-Tyr-Tyr-Ser-Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr (SEQ ID No:5);Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr-Phe-Gly-Gly-Gly-Thr-Lys-Leu-Gly (SEQ ID No:9);Cys-Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr-Cys (SEQ ID No:10);Ser-Gln-Gln-His-Tyr-Ser-Thr-Pro-Pro-Thr-Ser (SEQ ID No:11);Gln-Gln-His-Tyr-Ser (SEQ ID No:12); and,Thr-Pro-Pro-Thr (SEQ ID No:13) in an amount sufficient to effect said biological activity.