Patent ID: 8618169
Filing Date: 2013-12-31
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising, as an active ingredient, a compound having the general Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is an A-G(═K)—X—Y group, and wherein: A is alkyl or absent; G is C; K is selected from the group consisting of O and S; X is NRb; and Y is selected from the group consisting of an unsubstituted hydroxyalkyl, and a substituted or unsubstituted polyalkylene glycol residue, R each of R R each of Ra, Rb and Rc is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl, wherein when Y is a polyalkylene glycol residue, said polyalkylene glycol residue does not include a —ONO the composition being packaged in a packaging material and identified in print, in or on said packaging material, for use in increasing a current amplitude of a voltage-dependent potassium channel which comprises a KCNQ2 channel and/or a KCNQ3 channel and/or a KCNQ2/3 channel, said increasing said current amplitude comprising administering the pharmaceutical composition to a subject in need thereof.