Patent ID: 6319894
Filing Date: 2001-11-20
Classification: A61K,C07K

Abstract:
A complex comprising:a glycosylated polypeptide selected from the group consisting of mammalian fetuin, .alpha.2-HS glycoprotein, and combinations therof; anda positively charged (at physiological pH) therapeutic compound selected from the formula: ##STR7##wherein R is independently selected from the group consisting of phenyl, pyridine, amino-substituted pyridine, purine, oxo-substituted purine, C.sub.1-6 alkyl-substituted purine, xanthine, pyrimidine, C.sub.1-6 alkyl-substituted pyrimidine, and oxo-substituted pyrimidine; wherein X.sub.2 is selected from the group consisting of H.sub.2 N(CNH)--NH--N.dbd.CH--, H.sub.2 N(CNH)--NH--N.dbd.C(CH.sub.3)--, and H--; wherein X.sub.1, X'.sub.1 X'.sub.2 are independently selected from the group consisting of H.sub.2 N(CNH)--NH--N.dbd.CH-- and H.sub.2 N(CNH)--NH--N.dbd.C(CH.sub.3)--; wherein Z is selected from the group consisting of phenyl, pyridyl (C.sub.5 NH.sub.3), --NH(CO)NH--, straight or branched C.sub.2-10 alkyl, straight or branched C.sub.2-10 alkenyl, --A-- straight or branched C.sub.2-10 alkyl --A--, --A-- straight or branched C.sub.2-10 alkenyl --A--, and --A--, wherein A is independently selected from the group consisting of --NH(CO)--, --(CO)NH--, --NH(CO)NH--, --NH--, and --O--.