Patent ID: 6110892
Filing Date: 2000-08-29
Classification: A61K,C07K

Abstract:
A human parathyroid hormone hPTH analogue or pharmaceutically acceptable salts thereof, having the amino acid sequence:H-NH-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-R3-R4-R5-R6-Met-Gl u-Arg-Val-Glu-Trp-Leu-Arg-Lys-R11-Leu-Gln-Asp-NH.sub.2 (SEQ ID NO:33)whereinR3=His or a water soluble amino acid,R4=Leu or a water soluble amino acid,R5=Asn or a water soluble amino acid,R6=Ser or a water soluble amino acid,R11=Lys or Leu,cyclized in the form of a lactam between amino acid pairs 22 and 26; 26 and 30; or 27 and 30 when R11 is Lys,provided the analogue is not SEQ ID NO:7.