Patent ID: 9066960
Filing Date: 2015-06-30
Classification: A61K,A61P

Abstract:
1. A fraction of alkaloids having hypoglycemic activity, prepared by a process comprising: (a) extracting mulberry twig with solvents and precipitating the extract solution; (b) collecting the supernatant fluid, adding the collected supernatant fluid into cation exchange resin, and eluting the resin with a weak base eluent; and (c) collecting and concentrating the effluent, adding the concentrated effluent into anion exchange resin, collecting the part not absorbed to the anion exchange resin, and drying the collected part to obtain the fraction of alkaloids having hypoglycemic activity in powder, wherein the fraction of alkaloids having hypoglycemic activity comprises as the active ingredients a mixture of alkaloids, and wherein the percentage of the total alkaloids are 50% or more by weight in the fraction of alkaloids having hypoglycemic activity and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids, and wherein hypoglycemic activity of the fraction as determined by the IC