Patent ID: 6525074
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound of the formula A: wherein: R1a, R1b, R1c, R1d and R1e are independently selected from:a) hydrogen, b) aryl, heterocycle, C3-C10 cycloalkyl, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2Nâ€”C(O)â€”, CN, NO2, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, R10OC(O)â€”, â€”N(R10)2, or R11OC(O)NR10â€”, c) unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C2-C6 alkenyl or unsubstituted or substituted C2-C6 alkynyl, wherein the substituent on the substituted C1-C6 alkyl, substituted C2-C6 alkenyl or substituted C2-C6 alkynyl is selected from unsubstituted or substituted aryl, heterocyclic, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2Nâ€”C(O)â€”, CN, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, R10OC(O)â€”, â€”N(R10)2, and R11OC(O)â€”NR10â€”; R4 is selected from C1-4 alkyl, C3-6 cycloalkyl, heterocycle, aryl, unsubstituted or substituted with: a) C1-4 alkoxy, b) aryl or heterocycle, c) halogen, d) HO, f) â€”SO2R11, or g) N(R10)2; R6 and R7 are independently selected from hydrogen; C1-4 alkyl, C3-6 cycloalkyl, heterocycle, aryl, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, unsubstituted or substituted with: a) C1-4 alkoxy, b) aryl or heterocycle, c) halogen, d) HO, f) â€”SO2R11, or g) N(R10)2; or R6 and R7 may be joined in a ring; R8 is independently selected from: a) hydrogen, b) unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, NO2, R10C(O)â€”, R10OC(O)â€”, â€”N(R10)2, or R11OC(O)NR10â€”, and c) C1-C6 alkyl unsubstituted or substituted by unsubstituted or substituted aryl, unsubstituted or substituted heterocycle, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10OC(O)NHâ€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, R10C(O)â€”, R10C(O)â€”, â€”N(R10)2, or R10OC(O)NHâ€”; R9 is selected from: a) hydrogen, b) C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, CN, NO2, R10C(O)â€”, R10OC(O)â€”, â€”N(R10)2, or R11OC(O)NR10â€”, and c) C1-C6 alkyl unsubstituted or substituted by C1-C6 perfluoroalkyl, F, Cl, Br, R10Oâ€”, R11S(O)mâ€”, CN, R10C(O)NR10â€”, (R10)2NC(O)â€”, R102Nâ€”C(NR10)â€”, R10C(O)â€”, R10OC(O)â€”, â€”N(R10)2 or R11OC(O)NR10â€”; R10 is independently selected from hydrogen, C1-C6 alkyl, benzyl, unsubstituted or substituted aryl and unsubstituted or substituted heterocycle; R11 is independently selected from C1-C6 alkyl unsubstituted or substituted aryl and unsubstituted or substituted heterocycle; A1 is O; A2 is a bond; W is selected from imidazolyl and pyridinyl; V is phenyl; X is selected from â€”NR10C(O)â€”, â€”N(R10)â€” and â€”N(R10)S(O)2â€”; Y is selected from â€”C(O)â€”, â€”C(O)NR10â€”, â€”NR10C(O)â€”, â€”NR10C(O)â€”Oâ€”, â€”Oâ€”C(O)NR10â€”, â€”NR10C(O)NR10â€”, O, â€”N(R10)â€”, â€”S(O)2N(R10)â€”, â€”N(R10)S(O)2â€” and S(O)m; Z1 is selected from unsubstituted or substituted phenyl and unsubstituted or substituted naphthyl, wherein the substituted phenyl or substituted naphthyl is substituted with one or more of: 1) C1-4 alkyl, unsubstituted or substituted with: a) C1-4 alkoxy, b) NR6R7, c) C3-6 cycloalkyl, d) aryl or heterocycle, e) HO, f) â€”S(O)mR4, or g) â€”C(O)NR6R7, 2) aryl or heterocycle, 3) halogen, 4) OR6, 5) NR6R7, 6) CN, 7) NO2, 8) CF3, 9) â€”S(O)mR4, 10) â€”C(O)NR6R7, or 11) C3-C6 cycloalkyl; Z2 is a bond; m is 0, 1 or 2; n is 0; p is 0; q is 1 or 2; r is 0 to 5; s is 0; and t is 1, 2, or 3; heterocycle is a stable 5- to 7-membered monocyclic or stable 8- to 11-membered bicyclic heterocyclic ring which is either saturated or unsaturated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O and S, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring; unless otherwise specifically defined, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted cycloalkyl, substituted aryl, substituted heteroaryl, and substituted heterocycle, may be substituted with 1 to 3 substituents, selected from F, Cl, Br, CF3, NH2, N(C1-C6 alkyl)2, NO2, CN, (C1-C6 alkyl)Oâ€”, (aryl)Oâ€”, â€”OH, (C1-C6 alkyl)S(O)mâ€”, (C1-C6 alkyl)C(O)NHâ€”, H2Nâ€”C(NH)â€”, (C1-C6 alkyl)C(O)â€”, (C1-C6 alkyl)OC(O)â€”, N3, (C1-C6 alkyl)OC(O)NHâ€”, phenyl, pyridyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, thienyl, furyl, isothiazolyl and C1-C20 alkyl; or a pharmaceutically acceptable salt or stereoisomer thereof.