Patent ID: 6150525
Filing Date: 2000-11-21
Classification: C07D

Abstract:
A process for the preparation of 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo-[3,2-b]pyridine (A), comprising the steps of:i) condensing 1-hydroxy-5-(dimethylaminomethyleneimino)pyrrolo[3,2-b]pyridine (F) with 1-methyl-4-piperidinone in the presence of a base to provide 1-hydroxy-5-(dimethylaminomethyleneimino)-3-(1-methyl-1,2,3,6-tetrahydropy ridin-4-yl)pyrrolo[3,2-b]pyridine (J);ii) optionally deprotecting (J) to provide 1-hydroxy-5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo-[3,2- b]pyridine (H); andiii) hydrogenating either (J) or (H).