Patent ID: 8173130
Filing Date: 2012-05-08
Classification: A61K,C07K,Y02A

Abstract:
1. A method of treating inflammatory bowel disease (IBD) in a subject, comprising administering to the subject a therapeutically effective amount of an isolated monoclonal antibody which binds to and neutralizes flagellin, wherein the antibody is selected from the group consisting of: (a) an antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 1 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:3; and (b) an antibody comprising heavy and light chain variable region CDR1, CDR2 and CDR3, wherein the heavy chain variable region CDR1 comprises SEQ ID NO:5; the heavy chain variable region CDR2 comprises SEQ ID NO:7; the heavy chain variable region CDR3 comprises SEQ ID NO:9; the light chain variable region CDR1 comprises SEQ ID NO: 11; the light chain variable region CDR2 comprises SEQ ID NO: 13; and the light chain variable region CDR3 comprises SEQ ID NO: 15.