Patent ID: 8481069
Filing Date: 2013-07-09
Classification: A61K,A61P,Y10T

Abstract:
1. A biodegradable intravitreal implant comprising: a plurality of biodegradable polymer microspheres comprising a tyrosine kinase inhibitor (TKI) and a biodegradable polymer matrix, the microspheres releasing the TKI at a rate effective to sustain release of the TKI from the microspheres for at least about one week to about 1 year after the implant is placed in the vitreous of an eye, wherein the tyrosine kinase inhibitor is provided in an amount from about 40% by weight to about 60% by weight of the implant, and the biodegradable polymer matrix comprises a poly(lactide-co-glycolide) in an amount from about 40% by weight to about 60% by weight of the implant.