Patent ID: 8252337
Filing Date: 2012-08-28
Classification: A61K

Abstract:
1. A composition comprising: a positively charged mesoporous silica nanoparticle (MSN), which comprises: (a) a silica matrix, the entire substance of which comprises a plurality of silanol (Si—OH) and quaternary ammonium functional groups wherein the quaternary ammonium functional groups are from an organosilane quaternary ammonium compound comprising the formula: wherein R (b) an array of pores and/or nanochannels in the matrix, each pore and/or nanochannel having a surface lining the wall thereof; wherein the surface lining the wall of each pore and/or nanochannel comprises a plurality of silanol (Si—OH) and quaternary ammonium functional groups, and the positively charged MSN, in the absence of adsorption of a negatively charged compound, has a total pore volume of no smaller than 0.967 cm