Patent ID: 7645802
Filing Date: 2010-01-12
Classification: A61K,A61P

Abstract:
1. A modified release bupropion hydrobromide composition comprising: a core comprising a therapeutically effective amount of bupropion hydrobromide; and a controlled release polymeric coat comprising from about 1% to about 12% by weight of tablet dry weight of a water-insoluble polymer and from about 1.5% to about 10% by weight of tablet dry weight of a water-soluble polymer; wherein said coat at least partially surrounds said core; and wherein said composition releases bupropion hydrobromide in a first dissolution medium consisting of 0.1 N HCl and 5%-40% v/v ethanol at a rate that is less than or equal to about 1.1 times the rate of release of bupropion hydrobromide from an identical modified release pharmaceutical composition in a second dissolution medium consisting of 0.1 N HCl, measured over a time period of at least from 0 to 2 hours measured using a USP Apparatus I at 75 rpm and at 37±0.5° C.