Patent ID: 6110929
Filing Date: 2000-08-29
Classification: A61P,C07D

Abstract:
A compound of the formula I: ##STR68## wherein: R.sub.1 is selected from the group consisting of oxygen, sulfur and selenium;R.sub.2 is selected from the group consisting of-hydrogen;-alkyl;-alkyl-OH;-haloalkyl,-alkenyl;-alkyl-X-alkyl;-alkyl-X-alkenyl;-alkenyl-X-alkyl;-alkenyl-X-alkenyl;-alkyl-N(R.sub.5).sub.2 ;-alkyl-N.sub.3 ;-alkyl-O--C(O)--N(R.sub.5).sub.2 ;-aryl;-alkyl-X-aryl; and-alkenyl-X-aryl;n is 1 to 4;each R is independently selected from the group consisting of-alkyl,-alkoxy,-alkylthio,-hydroxy,-halogen,-haloalkyl,-polyhaloalkyl,-perhaloalkyl,-trifluoroalkoxy,-nitro,-amino,-alkylamino,-dialkylamino,-alkylcarbonyl,-alkenylcarbonyl,-arylcarbonyl,-aryl,-arylalkyl,-nitrile and-alkoxycarbonyl;X is selected from the group consisting of --O--, --S--, --NR.sub.5 --, --C(O)--, --C(O)O--, --OC(O)--, and a bond; andeach R.sub.5 is independently H or C.sub.1-8 alkyl;or a pharmaceutically acceptable salt thereof.