Patent ID: 6638947
Filing Date: 2003-10-28
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having Formula II: or a pharmaceutically acceptable salt or prodrug thereof, whereinY is oxygen or sulfur; R1 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R21, R22 and R23 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, halo alkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl, or R21, is defined as above, and R22 and R23 together with the nitrogen atom to which they are attached form a heterocycle selected from the group consisting of piperidine, piperazine and morpholine; A2 is aryl, heteroaryl, saturated or partially unsaturated carbocycle or saturated or partially unsaturated heterocycle, any of which is optionally substituted with one or more substituents selected from the group consisting of halo, haloalkyl, saturated or partially unsaturated heterocycle, cycloalkyl, heteroaryl, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, cycloalkylalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, alkoxyalkyl, nitro, amino, ureido, cyano, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, aminocarbonyl, and alkylthiol; provided that A2 is other than optionally substituted phenyl; X is one of O, S, or SO; and R3, R4, R5 and R6 independently are hydrogen, halo, haloalkyl, cycloalkyl, saturated or partially unsaturated heterocycle, heteroaryl, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, cycloalkylalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, alkoxyalkyl, nitro, amino, ureido, cyano, acylamido, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido or alkylthiol; or R3 and R4 or R5 and R6 form a bridge selected from the group consisting of â€”OCH2Oâ€”, OCF2Oâ€”, â€”(CH2)3â€”, â€”(CH2)4â€”, â€”OCH2CH2Oâ€”, â€”CH2N(R7)CH2â€”, â€”CH2CH2N(R7)CH2â€”, â€”CH2N(R7)CH2CH2â€” and â€”CH&boxH;CHâ€”CH&boxH;CHâ€”; where R7 is hydrogen, alkyl or cycloalkyl.