Patent ID: 6368604
Filing Date: 2002-04-09
Classification: A61K,A61P,Y02A

Abstract:
A composition comprising an isolated and purified lipopolysaccharide (LPS) component obtained from a double mutant E. coli strain which is designated E. coli htrB1::Tn10 msbB::&OHgr;cam and having ATCC Accession No. PTA-2794, wherein said LPS component has the following properties:(1) stimulates &bgr; chemokine secretion from mononuclear cells; (2) reduces secretion of proinflammatory cytokines including at least one cytokine selected from the group consisting of IL-&bgr;, IL-6 and TNF-&agr;; and, (3) suppresses replication of HIV-1 in mononuclear cells.