Patent ID: 6274556
Filing Date: 2001-08-14
Classification: A61K,A61P,C07K

Abstract:
A compound represented by the following structural formula:R.sup.1 --X--Y'--Z--R.sup.2wherein:Y' is a pentapeptide having the sequence Leu-Asp-Thr-Ser-Leu (SEQ ID NO: 1);X and Z are independently chosen from the group consisting of a covalent bond, an amino acid or a peptide, wherein each amino acid in X and Z is independently selected from the group of naturally occurring amino acids;R.sup.1 is R.sup.3 --CO--;R.sup.2 is --NR.sup.4 R.sup.5 ;R.sup.3 is selected from the group consisting of a lower alkyl group, a substituted lower alkyl group, an aryl group, a substituted aryl group, a heteroaryl group and a substituted heteroaryl group;R.sup.4 and R.sup.5 are each independently selected from the group consisting of hydrogen, a lower alkyl group, a substituted lower alkyl group, an aryl group, a substituted aryl group, a heteroaryl group and a substituted heteroaryl group, wherein:1) R.sup.4 and R.sup.5 are not both --H; and2) taken together, R.sup.4 and R.sup.5 can form a heterocyclic ring;taken together, X, Y' and Z form a peptide containing no more than about fifteen amino acids; andwherein optionally the peptide formed from X, Y' and Z is cyclized.