Patent ID: 7872013
Filing Date: 2011-01-18
Classification: A61K,A61P,C07B,C07D

Abstract:
1. A compound of Formula 1: or a single enantiomer, a mixture of a (+)-enantiomer and a (−)-enantiomer, a mixture of about 90% or more by weight of the (−)-enantiomer and about 10% or less by weight of the (+)-enantiomer, a mixture of about 90% or more by weight of the (+)-enantiomer and about 10% or less by weight of the (−)-enantiomer, an individual diastereomer, or a mixture of diastereomers thereof; or a pharmaceutically acceptable salt thereof, wherein: any bond represented by a dashed line and a solid line represents a bond selected from the group consisting of a single bond and a double bond, and any carbon-carbon double bond has a configuration selected from the group consisting of cis and trans; R R R when the bond represented by a dashed line and a solid line represents a double bond, X and Y are independently selected from the group consisting of C—H, and C-D; when the bond represented by a dashed line and a solid line represents a single bond, X and Y are independently selected from the group consisting of CH Z is selected from the group consisting of C(H)OH, C(H)OD, C(D)OH, C(D)OD, and carbonyl (C═O); provided that a compound of Formula 1 contains at least one deuterium atom and that deuterium enrichment in a compound of Formula 1 is at least about 1%; and with the proviso that a compound of Formula 1 cannot be selected from the group consisting of: