Patent ID: 7229960
Filing Date: 2007-06-12
Classification: A61K,C07K

Abstract:
1. A method for treating a subject having a cancer characterized by overexpression of Grb7 comprising administering to a subject in need of such treatment a compound consisting of a non-phosphorylated Grb7 binding peptide consisting of the amino acid sequence set forth as SEQ ID NO:4, 5, 35, 42, 50, or 51, in an amount effective to inhibit metastasis, wherein the binding peptide is attached to a translocation agent capable of transporting the peptide into cell cytoplasm or the nucleus of a cell, binds to the SH2 domain of Grb7 and does not specifically bind the SH2 domain of Grb2 or Grb14, and wherein the peptide is administered locally to the cancer.