Patent ID: 6803385
Filing Date: 2004-10-12
Classification: C07C

Abstract:
A composition for the treatment of dry eye in humans comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of one or more compounds of the following formula I:n-C5H11â€”Yâ€”Aâ€”CH2â€”R1â€ƒâ€ƒI wherein:R1 is CO2R, where R is lower alkyl; A is L1â€”A1â€”L2, L1â€”A2â€”L2, L3â€”A2â€”L4, or L5â€”A2â€”L3; A1 is CH2CH2; A2 is L1 is CH2â€”Bâ€”D; B and D are the same or different and are CH2CH2, CH&boxH;CH, or Câ‰¡C; L2 is CH2â€”Kâ€”CH2CH2; K is CH2CH2, CH&boxH;CH, or Câ‰¡C; L3 is CH2CH2CH2, CH2CH&boxH;CH, CH2Câ‰¡C, CH&boxH;CHCH2, Câ‰¡CCH2, or CH&boxH;C&boxH;CH; L4 is Xâ€”CH2CH2; X is CH2CH2CH&boxH;CH, CH2CH2Câ‰¡C, CH2CH2CH2CH2, CH2CH&boxH;CHCH2, CH2Câ‰¡CCH2, CH&boxH;CHCH2CH2, Câ‰¡CCH2CH2, CH2CH&boxH;C&boxH;CH, or CH&boxH;C&boxH;CHCH2; L5 is CH2CH2â€”Bâ€”D; and Y is C(O) (i.e. a carbonyl group) or Y is wherein R9O constitutes a free or functionally modified hydroxy group.