Patent ID: 6265601
Filing Date: 2001-07-24
Classification: B01J,C07B,C07C,C07F

Abstract:
A process, comprising, providing reactants for a cross coupling reaction and reacting said reactants in the presence of(1) a ligand characterized by the general formula ##STR12##whereineach R.sup.1 and R.sup.2 is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl;each of R.sup.3 is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, silyl, amino, nitro, ester, acid, alkoxy, aryloxy, hydroxy, transition metals, COOH, SO.sub.3 G (wherein G is selected from the group consisting of Na, K and H) and combinations thereof; a is 0, 1 or 2 such that R.sup.3, when present, occupies either the para position or the two meta positions;each of R.sup.4 is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, silyl, amino, nitro, ester, acid, alkoxy, aryloxy, hydroxy, transition metals, COOH, SO.sub.3 G (wherein G is selected from the group consisting of Na, K and H) and combinations thereof; b is 0, 1 or 2, such that when R.sup.4 is present, it occupies either one or two ortho positions; and(2) a metal precursor compound characterized by the general formula M(L).sub.n, where M is a transition metal selected from the group consisting of Pd, Ni, Fe, Co, Ru, Ir and Pt; L is independently each occurrence, a ligand; and n is 0, 1, 2, 3, 4, and 5;wherein said process has a turn over number (TON) of at least 50 and a turn over frequency (TOF) of at least 5.