Patent ID: 6590118
Filing Date: 2003-07-08
Classification: C07C,C07D,C07F

Abstract:
A compound of formula (I): as well as any optical or geometric isomer or tautomeric form thereof and mixtures of these or a pharmaceutically acceptable basic organic or inorganic addition salt or hydrate or prodrug thereof, whereinas well as any optical or geometric isomer or tautomeric form thereof and mixtures of these or a pharmaceutically acceptable basic organic or inorganic addition salt or hydrate or prodrug thereof, whereinA is â€”Oâ€”, â€”Sâ€”, >SO, >SO2, >CO, >CR9R10, or >NR11; R1 and R2 independently are one of the following groups: hydrogen, CN, â€”C(O)NR6R7, â€”COOH, â€”PO(OH)2, â€”SO2OH, tetrazole, 1-hydroxy-1,2-diazole, 1-hydroxytriazole, 1-hydroxyimidazole, 2-hydroxytriazole, or 1-hydroxytetrazole; when R1 or R2 is hydrogen, the other of R1 and R2 is â€”PO(OH)2 or â€”SO2OH; R1 and R2 together may form an anhydride or an imide; R3 and R4 independently are C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, or C3-8-cycloalkyl, each optionally substituted with halogen, hydroxy, â€”SH, â€”SOR6, â€”SO2R6, â€”NR6R7, â€”NHCOR7, C1-8-alkoxy, NO2, trifluoromethoxy, carbamoyl, or â€”CONR6R7; or R3 or R4 independently are hydrogen, halogen, perhalomethyl, C1-8-alkoxy, C1-8-alkylthio, â€”SH, â€”SOR6, â€”SO2R6, trifluoromethoxy, â€”SO2OH, â€”PO(OH)2, â€”COOR6, â€”CN, hydroxy, â€”OCOR6, â€”NR6R7, â€”NHCOR7, â€”COC1-8-alkyl, â€”CONR6R7, â€”CONHSO2R7, â€”SO2NHR7, NO2, C1-8-alkoxycarbonyl, aryl, heteroaryl, C1-8-alkylphenyl, or tetrazole; R5 is â€”COâ€”R8; wherein R8 is aryl or heteroaryl, each optionally substituted with one or more substituents selected from halogen, hydroxy, â€”SH, â€”SOR6, â€”SO2R6, NO2, â€”NR6R7, â€”NHCOR7, C1-8-alkyl, C1-8-alkoxy, perhalomethoxy, carbamoyl, â€”CONR6R7, perhalomethyl, â€”OCOR6, â€”COâ€”R6, â€”OR6, C1-8-alkylthio, â€”SO2OH, â€”SO2CH3, â€”PO(OH)2, CN, â€”NHCOR7, â€”CONHSO2R7, â€”SO2NHR7, C1-8-alkoxycarbonyl, and tetrazole; wherein R6 and R7 independently are hydrogen, C1-8-alkyl, aryl, phenyl-C1-8-alkyl, or heteroaryl, each optionally substituted with one or more substituents selected from halogen, OH, NH2, NO2, â€”NH(C1-8-alkyl), â€”N(C1-8-alkyl)2, â€”NHCO(C1-8-alkyl), C1-8-alkoxy, and trifluoromethoxy; R9 and R10 independently are hydrogen, hydroxy, â€”SH, halogen, or C1-8-alkyl; and R11 is hydrogen, C1-8-alkyl, -carbonyl-C1-8-alkyl, or phenyl C1-8-alkyl.