Patent ID: 6667312
Filing Date: 2003-12-23
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I): wherein:X is â€”CHR3â€”, â€”CHR3-alkyl-, or â€”CHR3-alkenyl-; Z is â€”Sâ€”, â€”SOâ€”, or â€”SO2â€”; R1 is selected from the group consisting of: -alkyl; -aryl; -heteroaryl; -heterocyclyl; -alkenyl; â€”R4-aryl; â€”R4-heteroaryl; â€”R4-heterocyclyl; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -alkyl-Y-alkyl; -alkyl-Y-alkenyl; -alkyl-Y-aryl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R3)2; â€”COâ€”N(R3)2; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -heteroaryl; -heterocyclyl; â€”CO-aryl; and â€”CO-heteroaryl; each R3 is independently H or C1-10 alkyl; R4 is alkylene or alkenylene; Y is â€”Oâ€” or â€”S(O)0-2â€”; n is 0; and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, hydroxy, halogen and trifluoromethyl; or a pharmaceutically acceptable salt thereof.