Patent ID: 6831080
Filing Date: 2004-12-14
Classification: A61P,C07C,C07D

Abstract:
A compound of Formula I or a pharmaceutically acceptable salt thereof: whereinR is C1-4 alkyl or trifluoromethyl; R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl, in which said substituted phenyl is substituted with substituent independently selected from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy and nitro; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-4 alkyl and halogen; R4 is selected from the group consisting of di(C1-4 alkyl)amino, trifluoromethoxy and optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl with one or two substituents in which said substituent is independently selected from the group consisting of C1-4alkyl, aminomethyl, hydroxymethyl, chloro or fluoro; R5 is hydrogen, chloro or fluoro; or R4 and R5 taken together are â€”CH&boxH;CHâ€”CH&boxH;CHâ€” or â€”X(CH2)mYâ€” in which X and Y are each independently selected from the group consisting of CH2, (CH2)nN(R9)â€” and O, wherein m is 1 or 2; n is 0 or 1; R6, R7, and R8 are each independently selected from hydrogen, chloro and fluoro; and R9 is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxyethyl, C1-4 alkoxyethyl, cyclopropylmethyl, â€”CO2(C1-4alkyl), and â€”CH2CH2NR10R11 in which R10 and R11 are each independently hydrogen or C1-4 alkyl.