Patent ID: 6541505
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinX is NR1; R is hydrogen, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, fused arylcycloalkyl, fused heteroarylcycloalkyl, fused arylcycloalkenyl, fused heteroarylcycloalkenyl, fused arylheterocyclyl, fused heteroarylheterocyclyl, fused arylheterocyclenyl, fused heteroarylheterocyclenyl, aryl, fused cycloalkenylaryl, fused cycloalkylaryl, fused hieterocyclylaryl, fused heterocyclenylaryl, heteroaryl, fused cycloalkylheteroaryl, fused cycloalkenylheteroaryl, fused heterocyclenylheteroaryl or fused heterocyclylheteroaryl, provided that where L2 is a chemical bond then Q is attached to R through a carbon atom thereof or where R is hydrogen then L2 is not a chemical bond; R1 is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl, heteroaroyl, alkoxycarbonyl, aryloxycarbonyl or heteroaryloxycarbonyl; R2 and R3 are hydrogen, or taken together are &boxH;NR4; R4 is hydrogen, R5O2Câ€”, R5Oâ€”, HOâ€”, cyano, R5COâ€”, HCOâ€”, lower alkyl, nitro, or R6R7Nâ€”; R5 is alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; R6 and R7are independently hydrogen or alkyl; L1 is alkylene, alkenylene or alkynylene; L2 is a chemical bond, alkylene, alkenylene or alkynylene; Q is â€”NR8â€²â€”, â€”Oâ€”, â€”C(O)â€”, â€”C(O)â€”Oâ€”, â€”Oâ€”C(O)â€”, â€”NR8â€²C(X1)â€”, â€”C(X1)NR8â€²â€”, â€”NR8C(X1)Oâ€”, â€”OC(X1)NR8â€”,â€”NR8C(X1)NR8â€”, â€”NR8C(X1)NR8â€”, â€”S(O)nâ€”, â€”NR8SO2â€” or â€”SO2NR8â€”, provided that a nitrogen atom or oxygen atom of Q is not directly bonded to a carbon atom of L1 or L2 having a double bond or triple bond, or Q-L2â€”R is cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, fused arylcycloalkyl, fused heteroarylcycloalkyl, fused arylcycloalkenyl, fused heteroarylcycloalkenyl, fused arylheterocyclyl, fused heteroarylheterocyclyl, fused arylheterocyclenyl, fused heteroarylheterocyclenyl, aryl, fused cycloalkenylaryl, fused cycloalkylaryl, fused heterocyclylaryl, fused heterocyclenylaryl, heteroaryl, fused cycloalkylheteroaryl, fused cycloalkenylheteroaryl, fused heterocyclenylheteroaryl or fused heterocyclylheteroaryl, provided that a nitrogen atom or oxygen atom of Q is not directly bonded to a carbon atom of L1 having a double bond or triple bond; X1 is O or S; R8â€² is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl, heteroaroyl or alkoxycarbonyl; R8 is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl or heteroaroyl; and n is 0, 1 or 2, or an oxide thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or prodrug thereof.