Patent ID: 6355653
Filing Date: 2002-03-12
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is fur-2yl, lower alkyl substituted fur-2yl, pyridin-2yl, (4,5)dihydrofur-2yl, 2-pyrazol-1yl or phenyl; R2 and R4 are hydrogen; R3 is pyridin-2yl, pyridin-3yl, or pyridin-4yl, wherein said pyridinyl moieties are unsubstituted or substituted by one or two substituents selected from the group consisting of oxo, lower alkyl, halogen and lower alkoxy; or unsubstituted pyranyl, unsubstituted indolyl or unsubstituted thiophen; or unsubstituted phenyl or phenyl substituted by one or two substituents selected from the group consisting of trifluoromethyl, lower alkoxy, lower thioalkyl, â€”NHâ€”C(O)-lower alkyl, â€”NH2, â€”C(O)â€”CH3 and â€”NH(CH2)n-phenyl, wherein said phenyl is substituted by one or two substituents selected from the group consisting of halogen or lower alkoxy; R5 is â€”NH2, â€”N(lower alkyl)2, â€”NH(lower alkyl), â€”NHâ€”CH2â€”CH&boxH;CH2â€”, â€”NHC(O)O-lower alkyl, â€”NHâ€”C(O)(CH2)n-phenyl, wherein said phenyl is substituted by one or two substituents selected from the group consisting of halogen and â€”CF3; and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof.