Patent ID: 6414151
Filing Date: 2002-07-02
Classification: A61P,C07D

Abstract:
A process for preparing 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperizinyl)butyl]-2,4-imidazolidinedione having the formula: said process comprising the steps of:a) reacting 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione having the formula: â€ƒwith a carbon chain reagent comprising two leaving groups at the 1 and 4 positions in the presence of a mild base and a polar aprotic solvent to form a 3-N-alkylated 2,4-imidazolidinedione; and b) reacting said crude 3-N-alkylated 2,4-imidazolidinedione with 4-methylpiperizine to form 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperizinyl)butyl]-2,4-imidazolidinedione.