Patent ID: 6455074
Filing Date: 2002-09-24
Classification: A61K,A61P,Y10T

Abstract:
A method for forming a polymer-based sustained release device comprising the steps of:a) forming a polymer/biologically active agent solution by mixing a polymer, an effective amount of the biologically active and a continuous phase comprising a polymer solvent/polymer non-solvent mixture wherein the polymer and biologically active agent are present in relative concentrations such that the device contains about 50% by weight or more of the biologically active agent and the amount of non-solvent achieves solubilization of the biologically active agent and does not cause substantial precipitation of the polymer; b) forming droplets of the polymer/biologically active agent solution; c) freezing the droplets of the polymer/biologically active agent solution; and d) removing the continuous phase of step (a) from the polymer/biologically active agent solution, thereby forming a solid polymer/biologically active agent matrix.