Patent ID: 9024010
Filing Date: 2015-05-05
Classification: C07D,C07H

Abstract:
1. Process for preparing a glucopyranosyl-substituted benzyl-benzene derivative of general formula III, wherein R R R′ denotes hydrogen or C comprising the steps (S2), (S3) and (S4): (S2): reacting the organometallic compound of the formula VI wherein R with a gluconolactone of general formula IV wherein R in an organic solvent or a mixture of two or more organic solvents; and (S3): adding an aqueous solution comprising citric acid such that the reaction mixture forms an aqueous phase and an organic phase whereby the organic phase has a pH in the range from about 1 to 4; and (S4): separating the organic phase comprising the adduct obtained in the step (S2) from the aqueous phase; and (S5): reacting the obtained adduct with water or an alcohol R′—OH, where R′ denotes C