Patent ID: 8952148
Filing Date: 2015-02-10
Classification: A61K,C07D

Abstract:
1. Process for the preparation of Taurolidine which comprises: a. Reaction of Taurine and Cbz-cl in the presence of aqueous sodium hydroxide and toluene as solvent b. Separation of Cbz-taurine sodium salt precipitated out c. Conversion of Cbz-taurine sodium to Cbz-Taurinamide in the presence of PCl d. Conversion of Cbz-Taurinamide to taurinamide in presence of Pd/C followed by in situ generation of Taurinamide Succinate by reaction of Taurinamide and succinic acid e. Treatment of Taurinamide succinate with formaldehyde under basic conditions to generate Taurolidine.