Patent ID: 6114313
Filing Date: 2000-09-05
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition comprising a nucleotide analog, mannitol and a modifying additive which is sodium chloride or a polyol, wherein the nucleotide is a compound of formula wherein R.sup.1 and R.sup.2 independently represent hydrogen or halogen, R.sup.3 and R.sup.4 independently represent phenyl, or C.sub.1-6 -alkyl optionally substituted by one or more substituents selected from OR.sup.5, C.sub.1-6 -alkylthio, NR.sup.6 R.sup.7, phenyl, COOR.sup.8 and halogen,R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently represent hydrogen or C.sub.1-6 -alkyl, and X represents an acidic moiety, or a pharmaceutically acceptable salt thereof.