Patent ID: 6683189
Filing Date: 2004-01-27
Classification: A61K,C07D,C07K,C08G,C12Q

Abstract:
A polyamide of the formula:R3â€”Aâ€”(Yâ€”A)nâ€”R4 or a pharmaceutically acceptable salt thereof, wherein:each A is independently wherein each X is independently selected from the group consisting of N and Câ€”R1, each R1 is independently selected from the group consisting of H, CH3, OH, NH2, Cl, and CF3, and each R2 is independently selected from the group consisting of H, C1-10 alkyl, C1-10 alkeneyl, and C1-10 alkynyl, wherein at least one X is Câ€”OH or Câ€”NH2; n is 1-11; each Y is independently selected from the group consisting of: wherein each p is independently 0 to 3, and each q is independently 1-5; R3 is selected from the group consisting of: H, or NHâ€”R6, wherein R6 is selected from the group consisting of H, C(O)CH3, &ggr;-aminobutyric acid, &bgr;-alanine, glycine, ethylenediamine, 3,3â€²-diamino-N-methylpropylamine, tert-butoxycarbonyl (Boc), dimethylaminopropylamine (Dp), and ethylenediaminetetraacetic acid, wherein if R6 is &ggr;-aminobutyric acid, &bgr;-alanine, or glycine, R6 is optionally substituted at its amino terminus with &ggr;-aminobutyric acid, &bgr;-alanine, glycine, ethylenediamine, 3,3â€²-diamino-N-methylpropylamine, tert-butoxycarbonyl (Boc), dimethylaminopropylamine (Dp), or ethylenediaminetetraacetic acid; and R4 is selected from the group consisting of H, OH, CH3, NH2, &ggr;-aminobutyric acid, L-alanine, &bgr;-alanine, glycine, ethylenediamine, 3,3â€²-diamino-N-methylpropylamine, tert-butoxycarbonyl (Boc), dimethylaminopropylamine (Dp), ethylenediaminetetraacetic acid, and 3,3â€²-diamino-N-methylpropylamine-ethylenediaminetetraacetic acid, wherein if R4 is &ggr;-aminobutyric acid, L-alanine, &bgr;-alanine, or glycine, R4 is optionally substituted at its carboxyl terminus with &ggr;-aminobutyric acid, &bgr;-alanine, glycine, ethylenediamine, 3,3â€²-diamino-N-methylpropylamine, tert-butoxycarbonyl (Boc), dimethylaminopropylamine (Dp), ethylenediaminetetraacetic acid, or 3,3â€²-diamino-N-methylpropylamine-ethylenediaminetetraacetic acid.