Patent ID: 6184382
Filing Date: 2001-02-06
Classification: A61P,C07D

Abstract:
A process for preparing a 2-halo-3-nitro-4-aminopyridine compound of formula ##STR15##wherein X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group; X.sub.2 is Cl or F; Y is NR.sub.4, O or S; a=0 or 1; Z is of the formula ##STR16##wherein Z.sub.1 is N, CR.sub.5, (CH).sub.m -CR.sub.5 or (CH).sub.m -N, m being 1 or 2; and Z.sub.2 is N, NR.sub.6, O or S, n being 0 or 1;R.sub.4, R.sub.5 and R.sub.6 are independently H, alkyl, aryl or heterocyclyl; and R.sub.a and R.sub.b are independently H, OH, alkyl, hydroxyalkyl, alkyl mercaptyl, thioalkyl, alkoxy, alkoxyalkyl, amino, alkyl amino, carboxyl, acyl, halogen, carbamoyl, alkyl carbamoyl, aryl or heterocyclyl;comprising reacting a 2,4-dihalo-3-nitropyridine compound of formula ##STR17##wherein X.sub.1 is F and X.sub.2 is Cl or F with an amine of formula H.sub.2 N--X-(Y).sub.a -Z.