Patent ID: 8138187
Filing Date: 2012-03-20
Classification: A61P,C07D

Abstract:
1. Substituted heteroaryl derivatives of the formula I wherein A represents N or CR W represents O, S or NR with the proviso that if W represents O or S, A denotes CR one of the radicals B or C represents H; C wherein R or the radicals R and R 3 represents C 1-8 -alkyl, in each case saturated or unsaturated, branched or unbranched, mono- or polysubstituted or unsubstituted; C 3-8 -cycloalkyl, in each case mono- or polysubstituted or unsubstituted; aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted; aryl, heteroaryl or C 3-8 -cycloalkyl, bonded via C 1-3 -alkyl group and in each case unsubstituted or mono- or polysubstituted; R 4 represents H; C 1-5 -alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; aryl, or heteroaryl, in each case substituted or unsubstituted; aryl, heteroaryl or cycloalkyl, bonded via a C 1-3 -alkyl group and in each case mono- or polysubstituted or unsubstituted; COR 12 ; SO 2 R 12 , wherein R R 7 , R 8 , R 9 and R 10 independently of one another represent H, F, Cl, Br, I, NO 2 , CF 3 , OR 13 , SR 13 , SO 2 R 13 , SO 2 OR 13 , CN, COOR 13 , NR 14 R 15 , NHC(O)NHR 13 , NHC(O)R 13 , NH(CNR 13 )NHR 13 , SO 2 NHR 13 ; C 1-5 -alkyl, C 3-8 -cycloalkyl, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, unsubstituted or mono- or polysubstituted; or aryl, C 3-8 -cycloalkyl or heteroaryl, bonded via C 1-3 -alkyl and unsubstituted or mono- or polysubstituted; wherein R or R 7 , R 8 and R 9 have the abovementioned meaning and R 10 together with B represents —CH 2 CH 2 CH 2 — and R 10 and B therefore form a six-membered ring, R 14 and R 15 independently of one another denote H; C 1-5 -alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; or C 3-8 -cycloalkyl, in each case saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, unsubstituted or mono- or polysubstituted; or aryl, C 3-8 -cycloalkyl or heteroaryl, bonded via C 1-3 -alkyl and unsubstituted or mono- or polysubstituted; or R 14 and R 15 together form CH 2 CH 2 OCH 2 CH 2 , CH 2 CH 2 NR 16 CH 2 CH 2 or (CH 2 ) 3-6 , wherein R in the form of the racemate; of the enantiomers, diastereomers, mixtures of the enantiomers or diastereomers or of an individual enantiomer or diastereomer; of the bases and/or salts of physiologically acceptable acids.