Patent ID: 7718632
Filing Date: 2010-05-18
Classification: A61K,A61P,C12N

Abstract:
1. A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein: a. the sense strand comprises at least 15 contiguous nucleotides from the sense strand of ND8453 (SEQ ID NO: 1425), and the antisense strand comprises at least 15 contiguous nucleotides from the antisense strand of ND8453 (SEQ ID NO: 1426); or b. the sense strand comprises at least 15 contiguous nucleotides from the sense strand of ND8489 (SEQ ID NO: 1497), and the antisense strand comprises at least 15 contiguous nucleotides from the antisense strand of ND8489 (SEQ ID NO: 1498); or c. the sense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the sense strand of ND8456 (SEQ ID NO: 1431), and the antisense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the antisense strand of ND8456 (SEQ ID NO: 1432).