Patent ID: 6589947
Filing Date: 2003-07-08
Classification: A61K,A61P

Abstract:
A method of treating Syndrome X in a mammal which comprises administering to said mammal a therapeutically effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof, whereinA is â€”CR7 or N; B is â€”NHCHR1R2, or â€”OCHR1R2; Z is 0, S â€”NH or â€”N(C1-C2)alkyl; R1 is C1-C4 alkyl which may optionally contain one double or triple bond and which may optionally be substituted with one or two substituents selected independentlyfrom hydroxy and C1-C4 alkoxy; R2 is C1-C12 alkyl which may optionally contain one double or triple bond and which may optionally be substituted with from one to three C1-C6 alkoxy; R3 is methyl; R4 is hydrogen, methoxy, amino, nitro, â€”NH(C1-C4alkyl), â€”N(CH3)2, â€”COOCH3, or C1-C4 alkyl one optionally substituted by hydroxy, C1-C3 alkoxy, or chloro; R5 is phenyl or pyridyl, wherein each R5 is substituted with two or three substituents, independently selected from fluoro, chloro, C1-C6 alkyl optionally containing one carbon-carbon double or triple bond, and C1-C4 alkoxy, and wherein one of said substituents can be further selected from hydroxy, jodo, bromo, formyl, and trifluoromethyl, and wherein said C1-C6 alkyl R5 group may optionally be substituted with one fluoro, hydroxy, or C1-C2alkoxy; and R7 is hydrogen or methyl.