Patent ID: 8022268
Filing Date: 2011-09-20
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
1. A transgenic mouse whose genome comprises a transgene, said transgene comprising a DNA sequence encoding a human amyloid precursor protein (hAPP) comprising Alzheimer's disease (AD) pathogenic mutations; wherein said DNA sequence is operably linked to the prion protein (PrP) promoter; wherein said hAPP is human APP 695 (hAPP 695), wherein the mutations are the Arctic mutation E693G and the Swedish mutations K670N, M671L; and further wherein said transgene is expressed and results in the deposition of amyloid-β (Aβ) in the brain parenchyma and cerebral blood vessels and is associated with reduced vasoreactivity and brain blood flow.