Patent ID: 7592422
Filing Date: 2009-09-22
Classification: A61K,A61P,C07K

Abstract:
1. A modified plasminogen activator inhibitor type-1 (PAI-1) molecule comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:2, in which one or more amino acid residues are each substituted by an amino acid residue that contains a sulfhydryl group, such that one or more disulfide bridges are formed at a position selected from the group consisting of 31, 97, 192, 197, 347, and 355 of SEQ ID NO:2, wherein said modified PAI-1 molecule has a half-life that is longer than the half-life of a corresponding wild-type PAI-1 molecule, and wherein said modified PAI-1 molecule inhibits urokinase plasminogen activator.