Patent ID: 6761905
Filing Date: 2004-07-13
Classification: A61K,Y10S

Abstract:
A thermal adhesion granulation process for preparing direct tabletting formations or aids, comprising the step of subjecting all or part of a mixture comprising:(a) from about 5 to about 99% by weight of one or more diluent excipients and/or from 0 to about 99% by weight of a pharmaceutically-active ingredient; (b) from about 1 to about 95% by weight of a binder excipient; and optionally with, (c) from 0 to about 10% by weight of a disintegrant excipient; to heating at a temperature range of from about 30 to about 130Â° C. under the condition of from about 0.1 to about 20% initial moisture content or from about 0.1 to about 20% initial content of a pharmaceutically-acceptable organic solvent in a closed system with mixing until granules form.