Patent ID: 9180137
Filing Date: 2015-11-10
Classification: A61K,A61L,A61P

Abstract:
1. A method for the preparation of an injectable ready-to-use bone cement paste composition comprising a) preparing a mixture consisting of calcium sulfate hemihydrate, a powdered calcium phosphate component, and calcium sulfate dihydrate to form a bone cement powder, b) mixing the bone cement powder from step a) with water, saline, or an iohexol solution for a period of time, c) allowing the mixture from step b) to sit for a period of time and d) admixing a bioactive agent to the mixture from step c) by means of a short-duration mixing using a minimum of energy, wherein the bioactive agent has a retarding effect on the hardening of the bone cement paste, and wherein the injectable ready-to-use bone cement paste composition from step d) has an initial setting time of not less than 5 minutes, and wherein the calcium phosphate component is hydroxyl apatite in an amount ranging from 30 to 50 wt % of the dry powder.