Patent ID: 6812368
Filing Date: 2004-11-02
Classification: C07B,C07C,C07D

Abstract:
A process, wherein a compound of formula (I) wherein R, Râ€² and Râ€³ are independently of each other a radical being compatible with the reaction conditions,except compounds whereina) one R is H and the other R is â€”CH2CN, Râ€³ is H and Râ€² is â€”C(&boxH;O)ORb and Rb is a H or a carboxy-protecting group; b) one R is H and the other R is â€”CH2C(&boxH;O)NR*R**, Râ€³ is H and Râ€² is â€”C(&boxH;O)ORb and R* and R** are independently of each other H or an amide-protecting group and Rb is H or a carboxy-protecting group; c) one R is H and the other R is â€”CH2C(&boxH;O)ORb, Râ€³ is H and Râ€² is â€”CH2â€”N3 and Rb is H or a carboxy-protecting group; and d) one R is H and the other R is â€”CH2C(&boxH;O)ORb, Râ€³ is H and Râ€² is â€”CH2â€”Rd and Rb is H or a carboxy-protecting group and Rd is halogen; is reduced with hydrogen to the corresponding diol, which is predominantly in the form of the syn-diol, in the presence of a magnesium salt and a heterogeneous platinum catalyst in a solvent.