Patent ID: 6166022
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR16## wherein: R.sup.1 is a C.sub.1-6 alkyl, C.sub.3-8 -cycloalkyl or a phenyl group, each group being optionally substituted by one or more substituents selected from halogen, OR.sup.6, NR.sup.7 R.sup.8, SR.sup.9 or C.sub.1-6 alkyl (itself optionally substituted by one or more halogen atoms);R.sup.2 is C.sub.1-8 alkyl optionally substituted by one or more substituents selected from halogen, OR.sup.6, NR.sup.7 R.sup.8, SR.sup.9, C.sub.3-8 -cycloalkyl, aryl (optionally substituted by one or more alkyl groups and/or halogen atoms), or C.sub.1-6 -alkyl; orR.sup.2 is a C.sub.3-8 -cycloalkyl group optionally substituted by one or more substituents selected from halogen, OR.sup.6, NR.sup.7 R.sup.8, SR.sup.9, C.sub.1-6 -alkyl or phenyl (the latter two being optionally substituted by one or more substituents selected from halogen, NO.sub.2, C(O)R.sup.6, OR.sup.6, SR.sup.9, NR.sup.10 R.sup.11, phenyl and C.sub.1-6 -alkyl which is optionally substituted by one or more halogen atoms);one of R.sup.3 or R.sup.4 is hydrogen and the other is hydroxy;X is OH or NHR.sup.5 ;R.sup.5 is a C.sub.1-6 -alkyl group substituted by COOH or C(O)NR.sup.7 R.sup.8 and optionally by one or more further substituents selected from halogen, OR.sup.12, C(NH)NR.sup.13 R.sup.14, C(O)NR.sup.15 R.sup.16 phenyl (optionally substituted by one or more groups selected from halogen, NO.sub.2, C(O)R.sup.6, OR.sup.6, NR.sup.7 R.sup.8, SR.sup.9 and C.sub.1-6 -alkyl) or C.sub.1-6 -alkyl (optionally substituted by one or more hydroxy or phenyl groups);R.sup.6, R.sup.9, R.sup.12, R.sup.13, R.sup.14, R.sup.15, and R.sup.16 are independently hydrogen or C.sub.1-6 -alkyl;R.sup.7 and R.sup.8 are independently hydrogen, C.sub.1-6 -alkyl (optionally substituted by one or more phenyl groups) or phenyl groups; andR.sup.10 and R.sup.11 are independently hydrogen, C.sub.1-6 -alkyl or acyl groups;or a pharmaceutically acceptable salt or solvate thereof.