Patent ID: 6306870
Filing Date: 2001-10-23
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR9##whereinR.sup.0 represents -hydrogen or -halogen;R.sup.1 is selected from the group consisting of:-hydrogen,--NO.sub.2,-trifluoromethyl,-trifluoromethoxy,-halogen,-cyano,a 5- or 6-membered heterocyclic group selected from the group consisting of pyridyl, pyrrolidinyl, morpholinyl, tetrahydrofuryl, furyl, tetrazolyl, imidazolyl, piperidinyl, and piperizinyl (optionally substituted by --C(.dbd.O)OR.sup.a or C.sub.1-4 alkyl),--C.sub.1-6 alkyl optionally substituted by OR.sup.a,--C.sub.1-3 alkoxy,--C(.dbd.O)R.sup.a,--O--C (.dbd.O)R.sup.a,--C(.dbd.O)OR.sup.a,--C.sub.1-4 alkyleneC(.dbd.O)OR.sup.a,--O--C.sub.1-4 alkylene-C(.dbd.O)OR.sup.a,--C.sub.1-4 alkylene-O--C.sub.1-4 alkylene-C(.dbd.O)OR.sup.a,--C(.dbd.O)NR.sup.a CO.sub.2 R.sup.c,--C(.dbd.O)C.sub.1-4 alkyleneHet, wherein Het represents 5- or 6-membered heterocyclic group as defined above,--C.sub.1-4 alkyleneNR.sup.a R.sup.b,--C.sub.2-6 alkenyleneNR.sup.a R.sup.b,--C(.dbd.O)NR.sup.a R.sup.b,--C(.dbd.O)NR.sup.a R.sup.c,--C(.dbd.O)NR.sup.a C.sub.1-4 alkyleneOR.sup.b,--C(.dbd.O)NR.sup.a C.sub.1-4 alkyleneHet, wherein Het represents a 5- or 6-membered heterocyclic group as defined above,--OR.sup.a,--OC.sub.2-4 alkyleneNR.sup.a R.sup.b,--OC.sub.1-4 alkylene-CH(OR.sup.a)CH.sub.2 NR.sup.a R.sup.b,--O--C.sub.1-4 alkyleneHet, wherein Het represents a 5- or 6-membered heterocyclic group as defined above,--O--C.sub.2-4 alkylene-OR.sup.a,--O--C.sub.2-4 alkylene-NR.sup.a --C(.dbd.O)--OR.sup.b,--NR.sup.a R.sup.b,--NR.sup.a C.sub.1-4 alkyleneNR.sup.a R.sup.b,--NR.sup.a C(.dbd.O)R.sup.b,--NR.sup.a C(.dbd.O)NR.sup.a R.sup.b,--N(SO.sub.2 C.sub.1-4 alkyl).sub.2,--NR.sup.a (SO.sub.2 C.sub.1-4 alkyl),--SO.sub.2 NR.sup.a R.sup.b, and--OSO.sub.2 trifluoromethyl;R.sup.2 is selected from the group consisting of:-hydrogen,-halogen,--OR.sup.a,--C.sub.1-6 alkyl,--NO.sub.2, and--NR.sup.a R.sup.b,or R.sup.1 and R.sup.2, together form a 3- or 4-membered alkylene or alkenylene chain, optionally containing at least one heteroatom;a first R.sup.3 is selected from the group consisting of:-hydrogen,-halogen,--NO.sub.2,-trifluoromethoxy,--C.sub.1-6 alkyl, and--C(.dbd.O)OR.sup.a,and a second R.sup.3 and R.sup.4 together, and with the phenyl ring to which they are attached, form a 3- or 4-membered alkylene or alkenylene chain, optionally containing at least one heteroatom,R.sup.a and R.sup.b, which may be the same or different, are independently selected from hydrogen and C.sub.1-6 alkyl;R.sup.c represents phenyl or C.sub.4-6 cycloalkyl, which phenyl or C.sub.4-6 cycloalkyl can be optionally substituted by one or more halogen atoms, one or more --C(.dbd.O)OR.sup.a or one or more --OR.sup.a ;n is an integer selected from 1, 2 and 3;m is an integer selected from 1 and 2;and pharmaceutically acceptable salts and solvates thereof.