Patent ID: 9090938
Filing Date: 2015-07-28
Classification: A61B,C12Q,G01N

Abstract:
1. A method of implanting an embryo in a female undergoing in vitro fertilization, comprising the steps of: a) collecting at least one oocyte with its cumulus cells from said female; b) measuring, in said cumulus cells surrounding said oocyte, an expression level of each of the 10 genes ATF3, SIAT6, PRKACA, PLA2G5, GPC6, G0S2, RBMS1, NFIC, SLC40A1 and WNT6; c) comparing the expression level of each of the 10 genes in the cumulus cells with control expression levels of the 10 genes from cumulus cells associated with competent oocytes; d) assessing said oocyte as having a higher probability of being competent if a cumulus cell surrounding the oocyte does not overexpress any of the 10 genes when compared to cumulus cells associated with a competent oocytes; e) fertilizing said oocyte having a higher probability of being competent in vitro to generate an embryo; and f) implanting said embryo in said female.