Patent ID: 7292944
Filing Date: 2007-11-06
Classification: G01N

Abstract:
1. A method for determining the resistance of a patient to at least one HIV therapy comprising determining a cut-off fold resistance value for said at least one HIV therapy as determined according to a method for predicting resistance of an HIV infection to at least one HIV therapy, comprising: a) determining a sensitivity of a patient sample for said at least one HIV therapy, wherein the sensitivity of the patient sample is determined by performing at least one of a phenotyping assay and a genotyping assay; b) determining a sensitivity of a reference sample for said at least one HIV therapy, wherein the sensitivity of the reference sample is determined by performing at least one of a phenotyping assay and a genotyping assay; c) determining a patient fold resistance from a quotient of the sensitivity obtained in step a) over the sensitivity obtained in b); d) predicting the cut-off fold resistance of a disease toward the at least one HIV therapy by determining whether the patient fold resistance is above a cut-off fold resistance value, e) wherein the cut-off fold resistance value is determined from the mean and standard deviation of a distribution of patient fold resistance values for the at least one HIV therapy determined for a group of patients f) thereby determining the resistance of the patient to at least one HIV therapy.