Patent ID: 6210668
Filing Date: 2001-04-03
Classification: A61K,A61P,C07K

Abstract:
A method of treatment of a patient suffering from cancer, said method comprising the steps of:(a) preparing a stem cell transplant from a patient suffering from cancer;(b) treating said stem cell transplant by contacting said stem cell transplant with intact bispecific antibodies capable of binding to the T cell receptor complex of a T cell, to tumor-associated antigens on a tumor cell, and to Fc-receptors of accessory cells via the Fc part of the antibody, under conditions that allow(i) said binding of said bispecific antibody to said T cells, tumor cells, and Fc-receptor cells,(ii) activation of said T cells by said antibody binding,(iii) binding of said Fc-receptor positive cells to the Fc-region of said bispecific antibody,(iv) redirection of said T cells and Fc-receptor positive cells to said tumor cells,(v) destruction of said tumor cells by said activated T cells, and(vi) ADCC killing of said tumor cells by said Fc-receptor positive cells to reduce the number of contaminating tumor cells in said stem cell transplant ex vivo; and(c) reinfusing said stem cell transplant thus treated into said patient.