Patent ID: 8765681
Filing Date: 2014-07-01
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A method of enhancing apoptosis in a cell comprising contacting the cell with a compound of Formula I: or a salt thereof, wherein m is 0, 1 or 2; Y is NH, O or S; BG is —X-L-X X and X L is: wherein the aryl, biphenyl, heteroaryl, and heterocyclyl are optionally substituted with one or more R Q and Q Q and Q A and A R R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the aryl, heteroaryl, heterocyclyl, and heterobicyclyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R or R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R R whereby apoptosis in the cell is enhanced.