Patent ID: 8153430
Filing Date: 2012-04-10
Classification: A61K,A61P

Abstract:
1. A method for accelerating the rate of healing of a surgically created anastomosis in a treated patient compared to the rate of healing in an untreated patient, the method comprising the step of administering by injection directly to the anastomosis at the time the anastomosis is surgically created between 0.1-to-1000 μL per square centimeter of applied area a composition comprising Amnion-derived Cellular Cytokine Solution (ACCS) or pooled ACCS wherein the ACCS or pooled ACCS contains physiologic concentrations of VEGF, TGFβ2, Angiogenin, PDGF, TIMP-1 and TIMP-2, and wherein the physiologic concentration is about 5.0-16 ng/mL for VEGF, about 3.5-4.5 ng/mL for Angiogenin, about 100-165 pg/mL for PDGF, about 2.5-2.7 ng/mL for TGFβ2, about 0.68 μg/mL for TIMP-1 and about 1.04 μg/mL for TIMP-2.