Patent ID: 6653500
Filing Date: 2003-11-25
Classification: C07C,C07D

Abstract:
A method for reducing ethylN-(2,3-dichloro-6-nitrobenzyl) glycine (compound VI) to form ethylN-(6-amino-2,3 dichlorobenzyl) glycine (compound I) comprising the steps of:forming a suspension of ethylN-(2,3-dichloro-6-nitrobenzyl) glycine in concentrated HCl; forming a mixture of stannous chloride in concentrated HCl; adding the glycine suspension to the stannous solution at an elevated temperature; filtering the solids and dissolving the solids in water and an organic solvent; adjusting the pH of the solution to an alkaline pH; separating the organic phase and extracting the aqueous phase with an organic solvent; combining the organic phases and concentrating the solution to precipitate the solids; and collecting the solids as ethyl N-(6-amino-2,3-dichlorobenzyl) glycine.