Patent ID: 8889851
Filing Date: 2014-11-18
Classification: C07F,C07H

Abstract:
1. A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor wherein the cleavable adaptor is represented by —C L is a hydrocarbyl chain which may be optionally substituted with one to four substituent groups independently selected from the group consisting of 5-to 9-membered heteroaryl, 4- to 9-membered heterocyclyl, amino, ether, carboxyl, carbamoyl, (C L is a hydrocarbyl chain interspersed with other atoms, as represented by —(CHR′) Y is a linkage functional group selected from —O—, —S—, —NR′—, —NH—CO—O—, —O—CO—NH—, or —NH—CO—NH—, wherein R′ is hydrogen or (C