Patent ID: 6576431
Filing Date: 2003-06-10
Classification: A61K,C07K,Y10S

Abstract:
A method of detecting the presence of a fibrin-platelet clot in a biological sample, comprising:(a) contacting said sample with a monoclonal antibody or fragment thereof wherein said antibody or fragment thereof is specific to an epitope formed by the crosslinking of &agr;2-antiplasmin to fibrin and inhibits &agr;2-antiplasmin crosslinked to fibrin so as to increase endogenous fibrinolysis but does not interfere with the inactivation of circulating plasmin by soluble &agr;2-antiplasmin, and wherein said antibody is specific for an antigenic determinant characteristic of said clot, under conditions such that binding of said antibody to said antigenic determinant occurs, and (b) detecting the presence of said antibody bound to said antigenic determinant, said binding being related to the presence of a clot in said sample.