Patent ID: 6407096
Filing Date: 2002-06-18
Classification: C07D

Abstract:
A benzene fused heterocyclic derivative, represented by the following formula (II):wherein A1 is â€”Oâ€” or â€”Sâ€”;A2 is A3 is alkylene having 1 to 4 carbon atoms, alkenylene having 2 to 4 carbon atoms, or alkynylene having 2 to 4 carbon atoms; A4 is â€”S(O)pâ€”, â€”Oâ€”, â€”CH2â€”, â€”NR5â€”, â€”NR5COâ€”, or â€”CONR5â€”, wherein R5 is hydrogen, alkyl having 1 to 5 carbon atoms, or phenyl (which may be substituted by a group or groups selected from alkyl having 1 to 5 carbon atoms, phenyl, hydroxyl, alkoxy having 1 to 5 carbon atoms, phenoxy, halogen, trifluoromethyl, cyano, nitro, amino, and alkylamino having 1 to 5 carbon atoms), and p is an integer of 0 to 2; m is 1; R1 is â€”Xâ€”(CH2)nâ€”COOR6, wherein X is â€”Oâ€”, â€”Sâ€”, or â€”CH2â€”, R6 is hydrogen, alkyl having 1 to 5 carbon atoms, or an atom or group which gives a pharmacologically acceptable salt, and n is an integer of 1 to 3; R2 is selected from the group consisting of: (1) phenyl and naphthyl, wherein phenyl or naphthyl may be substituted by a group or groups selected from alkyl having 1 to 5 carbon atoms, phenyl hydroxyl, alkoxy having 1 to 5 carbon atoms, phenoxy, halogen, trifluoromethyl, cyano, nitro, amino, and alkylamino having 1 to 5 carbon atoms; or (2) alkyl having 1 to 5 carbon atoms, alkenyl having 2 to 5 carbon atoms, or alkynyl having 2 to 5 carbon atoms, wherein alkyl, alkenyl, or alkynyl is substituted by one or two Ar (wherein Ar is defined as the same as the above, and may be further substituted by a group or groups selected from â€”OH, â€”CF3, and cycloalkyl having 3 to 8 carbon atoms); R3 is hydrogen, halogen, alkyl having 1 to 5 carbon atoms, or alkoxy having 1 to 5 carbon atoms; and either or both of A1 and A2 contain a hetero atom other than carbon.