Patent ID: 6130220
Filing Date: 2000-10-10
Classification: C07C,C07D

Abstract:
A compound selected from the group of compounds represented by formula (I): ##STR41## wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocycloalkyl, heteroalkyl, or --(alkylene)--C(O)--X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl; or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a carbocycle or a heterocycle;R.sup.3 is hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, (diphenylmethyl)alkyl, or --(alkylene)--C(O)--X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl; or R.sup.3 together with either R.sup.1 or R.sup.2 and the atoms to which they are attached form a heterocycloamino group;R.sup.10 is --OH;R.sup.20 is hydrogen or alkyl; andR.sup.21 is cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaralkyl or heteroaralkenyl; or R.sup.20 and R.sup.21 together with the nitrogen atom to which they are attached form one of the following:(i) a heterocycloamino group substituted with at least one substituent selected from cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl-Q-, aryl-Q-, or heteroaryl-Q-where Q is an alkylene chain in which a methylene group is optionally replaced by --C(O)--, --O--, --S(O)n-- (where n is an integer from 0 to 2), --NR--(where R is hydrogen or alkyl), --NR.sup.a C(O)--, --C(O)NR.sup.a -- (where R.sup.a is hydrogen or alkyl), --NR.sup.b SO.sub.2 --, or --SO.sub.2 NR.sup.b -- (where R.sup.b is hydrogen or alkyl);(ii) a heterocycloamino group that is fused to a cycloalkyl, aryl or heteroaryl ring provided that either:(a) R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a carbocycle or a heterocycle, or(b) R.sup.3 together with either R.sup.1 or R.sup.2 and the atoms to which they are attached form a heterocycloamino group; or(iii) an optionally substituted tetrahydropyridine ring; orR.sup.20 or R.sup.21 together with R.sup.3 forms an alkylene group; andtheir pharmaceutically acceptable salts, prodrug esters or carbamates, individual isomers, and mixtures of isomers, provided that:(i) R.sup.1, R.sup.2, and R.sup.3 are not all hydrogen; and(ii) when R.sup.1 and R.sup.3 are hydrogen and R.sup.2 is alkyl, then R.sup.21 is not pyridylalkyl.