Patent ID: 6133255
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A compound of formula 1, or a salt thereof: ##STR6## wherein E represents --(CH.sub.2).sub.n --;n is 3;one of X and Y represents CH, nitrogen or N.sup.+ --O.sup.-, and the other represent CH;R.sup.1 represents methoxycarbonyl, ethoxycarbonyl, methylthiazolyl or hydroxymethylthiazolyl;R.sup.2 and R.sup.3 independently represent hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, indanyl, aryl, aryl(C.sub.1-6)alkyl, heteroaryl, heteroaryl(C.sub.1-6)alkyl, halogen, cyano, trifluoromethyl, nitro, --OR.sup.a, --OCOR.sup.3, --OSO.sub.2 R.sup.a, --SR.sup.a, --SOR.sup.a, --SO.sub.2 R.sup.a, --SO.sub.2 NR.sup.a R.sup.b, --NR.sup.a R.sup.b, --NR.sup.a COR.sup.b, --NR.sup.a CO.sub.2 R.sup.b, --COR.sup.a, --CO.sub.2 R.sup.a, or --CONR.sup.a R.sup.b ; wherein said alkyl, alkenyl, alkynyl, cycloalkyl, indanyl, aryl, heterocycloalkyl, and heteroaryl are optionally substituted by one or more groups selected from C.sub.1-6 alkyl, adamantyl, phenyl, halogen, C.sub.1-6 haloalkyl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 aminoalkyl, trifluoromethyl, hydroxy, C.sub.1-6 alkoxy, aryloxy, keto, C.sub.1-3 alkylenedioxy, nitro, cyano, carboxy, C.sub.2-6 alkoxycarbonyl, C.sub.2-6 alkoxycarbonyl(C.sub.1-6)alkyl, C.sub.2-6 alkylcarbonyloxy, arylcarbonyloxy, aminocarbonyloxy, formyl, C.sub.2-6 alkylcarbonyl, arylcarbonyl, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkylsulphonyl, arylsulphonyl, --NR.sup.v R.sup.w, --NR.sup.v COR.sup.w, --NR.sup.v CO.sub.2 R.sup.w, --NR.sup.v SO.sub.2 R.sup.w, --CH.sub.2 NR.sup.v SO.sub.2 R.sup.w, --NHCONR.sup.v R.sup.w, --CONR.sup.v R.sup.w, --SO.sub.2 NR.sup.v R.sup.w, and --CH.sub.2 SO.sub.2 NR.sup.v R.sup.w, in which R.sup.v and R.sup.w independently represent hydrogen, C.sub.1-6 alkyl, aryl or aryl(C.sub.1-6)alkyl; andR.sup.a and R.sup.b independently represent hydrogen, hydrocarbon or a heterocyclic group.