Patent ID: 6596722
Filing Date: 2003-07-22
Classification: A61P,C07D

Abstract:
A compound of formula: or any of its enantiomers or any mixtures thereof, or an acid addition salt thereof, whereinB is C1-10-alkylene, C2-10-alkenylene or C2-10-alkynylene; X is â€”Oâ€”, â€”Sâ€”, or â€”CR4R5â€”; and Y is â€”CR6R7â€”, â€”CR6R7â€”CR8R9â€”, or â€”CR6&boxH;CR7â€”; or X and Y together form a group â€”CR4&boxH;CR5â€”, or â€”CR4&boxH;CR5â€”CR6R7â€”; Z is â€”Oâ€” or â€”Sâ€”; W is N; R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen, halogen, trifluoromethyl, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, amino, C1-6-alkylamino, C1-6-dialkylamino, phenylamino or phenyl-C1-6-alkylamino, acylamino, hydroxy, â€”SH, cyano, nitro, â€”COOR18, â€”SO2â€”R19 and C1-6-alkyl substituted with a substituent selected from halogen, C1-6-alkoxy, C1-6-alkylthio, amino, C1-6-alkylamino, C1-6-dialkylamino, acylamino, hydroxy, â€”SH, cyano, nitro, â€”COOR18 and â€”SO2â€”R19; R18 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, phenyl or phenyl-C1-6-alkyl, amino, C1-6-alkylamino or C1-6-dialkylamino, and R19 is C1-6-alkyl, amino, C1-6-alkylamino, C1-6-dialkylamino, phenyl or phenyl-C1-6-alkyl; A is â€ƒwhich is attached to the remainder of the compound of formula (I) via a carbon atom or a nitrogen atom in any of the two rings and wherein the dotted line is an optional bond, E6 is O, and wherein any of the carbon atoms in the ring may be substituted with any of the substituents defined for R12-R17 below; R1, R2, R3, R12, R13, R14, R15, R16 and R17 are each independently selected from hydrogen, halogen, trifluoromethyl, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkoxy, hydroxy, formyl, acyl, amino, C1-6-alkylamino, C1-6-dialkylamino, acylamino, C1-6-alkoxycarbonylamino, aminocarbonylamino, C1-6-alkylaminocarbonylamino, C1-6-dialkylaminocarbonylamino, nitro, cyano and â€”SO2â€”R19; provided that when any R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, R14, R15, R16, R17, R18 or R19 is a phenyl group or has a phenyl moiety, said phenyl group or phenyl moiety is optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, cyano, nitro, amino, C1-6 alkylamino, C1-6 dialkylamino, C1-6 alkyl, C1-6 alkoxy and hydroxy.