Patent ID: 7288638
Filing Date: 2007-10-30
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A monoclonal antibody or antigen-binding portion thereof that specifically binds to 4-1BB, comprising a light chain variable region and a heavy chain variable region, wherein: said light chain variable region comprises a CDR1 having amino acids 44-54 of SEQ ID NO:6, a CDR2 having amino acids 70-76 of SEQ ID NO:6, and a CDR3 having amino acids 109-119 of SEQ ID NO:6; and said heavy chain variable region comprises a CDR1 having amino acids 50-54 of SEQ ID NO:3, a CDR2 having amino acids 69-84 of SEQ ID NO:3, and a CDR3 having amino acids 117-129 of SEQ ID NO:3.