Patent ID: 8709422
Filing Date: 2014-04-29
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of treatment, the method comprising administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or antigen-binding fragment thereof that binds selectively and at least 2 fold more efficiently to a misfolded form of a human SOD1 compared to a natively folded form of a human SOD1 and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively and at least 2 fold more efficiently to a misfolded form of a human SOD1 compared to a natively folded form of a human SOD1, wherein said antibody or binding fragment thereof binds to an epitope in the dimer interface of a human SOD1.