Patent ID: 8858764
Filing Date: 2014-10-14
Classification: G01N,Y10S

Abstract:
1. A method of configuring a nanodevice, the method comprising: filing a reservoir with a conductive fluid; configuring a membrane to separate the reservoir in the nanodevice, the membrane comprising an electrode layer having a tunneling junction formed therein; and configuring the membrane to have a nanopore formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer; wherein when a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base; wherein when an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base; and wherein the organic coating includes a selection from hydroxamic acid, resorcinol functionality, adnine monophosphonic acid, guanine monophosphonic acid, sulfonamides, and sulfonic acid.