Patent ID: 8410056
Filing Date: 2013-04-02
Classification: A61K,A61P,G01N

Abstract:
1. A method of testing whether a subject having cancer is likely to respond to therapy comprising the administration of a pro-oxidant compound, said method comprising the steps of: (i) introducing the pro-oxidant compound into mitochondria of a cancerous cell sourced from said subject; (ii) assaying for the binding of the pro-oxidant compound to a ubiquinone-binding site of complex II of the mitochondria, wherein said assay of step (ii) is selected from the group consisting of assaying for actual binding of the pro-oxidant compound with the ubiquinone-binding site of complex II, or assaying for an effect caused by the binding of the pro-oxidant compound with the ubiquinone-binding site of complex II wherein said effect is not death of the cancerous cell; and (iii) assaying for death of the cancerous cell, wherein the binding of the pro-oxidant compound and the death of the cancerous cell by the pro-oxidant compound indicates that the subject is likely to respond to the therapy.