Patent ID: 6355695
Filing Date: 2002-03-12
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinX is ORbd, wherein Rbd is hydrogen or C1-3alkyl, or NRbeRbf in which Rbe and Rbf are independently hydrogen, C1-4alkyl, C1-4hydroxyalkyl or C1-4alkanoyl, or the radical NRbeRbf is pyrrolidino, piperidino or morpholino; and Rbg is hydrogen or C1-4alkyl; with the proviso that X is not NHCH3; and wherein Q2 is a nitrogen-linked five-membered aromatic ring containing 1-4 nitrogens, which is substituted at a ring position adjacent to the nitrogen-link by a group Q5; Q3 is hydrogen or C1-3alkyl; Q4 is phenyl which may bear one or two substituents independently selected from halo, trifluoromethyl, hydroxy, C1-3alkoxy, C1-3alkyl and methylenedioxy; or Q4 is thienyl, imidazolyl, benzo[b]thiophenyl or naphthyl any of which may bear a halo substituent; or Q4 is biphenylyl; or Q4 is carbon-linked indolyl which may bear a benzyl substituent at the 1-position; and Q5 is selected from the group consisting of phenyl, benzyl, phenethyl and naphthyl, wherein any phenyl ring or naphthyl may bear one or more substituents selected from C1-3alkyl, C1-3alkoxy, methylenedioxy, halogeno, hydroxy, C1-4acyloxy and NRARB in which RA and RB are independently hydrogen or C1-3alkyl, or RA is hydrogen or C1-3alkyl and RB is C1-4acyl; or the N-oxide of a piperidino nitrogen indicated by &Dgr;; or a pharmaceutically acceptable salt thereof; or a quaternary ammonium salt thereof in which the piperidino nitrogen indicated by &Dgr; is a quadricovalent ammonium nitrogen wherein the fourth radical on the nitrogen R1 is C1-4alkyl or benzyl and the associated counterion A is a pharmaceutically acceptable anion.