Patent ID: 6759394
Filing Date: 2004-07-06
Classification: A61K,C07K,C12N

Abstract:
A DNA sequence comprising a promoter operatively linked to a transcription sequence; wherein the transcription sequence, when transcribed, produces a messenger RNA sequence that comprises a translatable sequence encoding a toxin, and an untranslated sequence; wherein the untranslated sequence inhibits translation of the toxin sequence under conditions that exist within normal mammalian cells that do not overexpress eukaryotic initiation factor eIF4E; wherein the untranslated sequence allows translation of the toxin sequence under conditions that exist within mammalian cells that everexpress eukaryotic initiation factor eIF4E relative to bormal cells; and wherein the untranslated sequence further comprises a hairpin secondary structure conformation having a stability measured as folded state free energy of &Dgr;G&lE;about âˆ’50 Kcal/Mol.