Patent ID: 9040688
Filing Date: 2015-05-26
Classification: C07D

Abstract:
1. A process for the preparation of the compound of formula (VIII), the process comprising the steps of a) reacting hydroxylamine or its derivative with a ketone of formula (I) to obtain an oxime of formula (II) wherein R=H, alkyl or silyl; b) reacting the oxime of formula (II) with an imine of formula (III), wherein R′=H or any phenolic protecting group to obtain β-(substituted-amino)amide of formula (IV); c) cyclizing the β-(substituted-amino)amide of formula (IV) to form an azetidinone of formula (V); d) converting the oxime functionality in the compound of formula (V) to a ketone of formula (VI); e) reducing the ketone functionality of a compound of formula (VI) to the alcohol of formula (VII); f) removing the phenolic protecting group at any desired stage in the above synthesis.