Patent ID: 6184220
Filing Date: 2001-02-06
Classification: A61K,Y10S

Abstract:
A pharmaceutical composition of matter which is an orally administered suspension comprisingparticles of a non-steroidal anti-inflammtory active substance selected from the acid enolcarboxamides (oxicams), and pharmaceutically acceptable salts thereof, having a suspendable particle size spectrum in which at least 90% of the particles are smaller than 50 .mu.m,a physiologically inert dispersion medium in which the particles of active substance are suspended and in which dispersion medium the active substance has a solubility of less than 500 .mu.g/ml, about 0.1 to about 5% by weight of highly dispersed silicon dioxide having a specific surface area of at least 50 m.sup.2 /g, forming a three-dimensional siloid structure produced by adding the silicon dioxide to the dispersion medium with the action of shear forces characterised by a circumferential rotor speed of about 15 to 35 m/s, andabout 0.05 to about 2% by weight of a hydrophilic polymer, which polymer is soluble in the dispersion medium.