Patent ID: 8613951
Filing Date: 2013-12-24
Classification: A61K,A61P,C07C,Y10S

Abstract:
1. A therapeutic nanoparticle comprising: about 5 to about 15 weight percent of a mTOR inhibitor; and about 50 to about 99 weight percent biocompatible polymer, wherein the biocompatible polymer is a diblock poly(lactic) acid-poly(ethylene)glycol copolymer, wherein said diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic acid) having a number average molecular weight of about 15 to 20 kDa and poly(ethylene)glycol having a number average molecular weight of about 4 to about 6 kDa, wherein the diameter of the therapeutic nanoparticle is about 70 to about 130 nm; and wherein the particle releases less than about 10% of the mTOR inhibitor over about one minute when placed in a phosphate buffer solution at room temperature.