Patent ID: 7050842
Filing Date: 2006-05-23
Classification: A61B

Abstract:
1. A method of noninvasive spectroscopic measurement of an analyte in a subject comprising: (a) irradiating tissue of the subject through a nail with electromagnetic radiation having an excitation wavelength while the tissue is in a blood-replete state; (b) collecting the Raman spectra emitted by the tissue in the blood-replete state; (c) applying a tissue modulation device having an orifice to the nail of the subject so as to achieve a blood-depleted state within the tissue; (d) irradiating the tissue through the nail with electromagnetic radiation having an excitation wavelength while the tissue is in the blood-depleted state; (e) collecting the Raman spectra emitted by the tissue in the blood-depleted state; and (f) analyzing the collected Raman spectra to determine a concentration of analyte present in the tissue, wherein the analyzing comprises determining the difference between the Raman spectra collected in the blood-replete and blood-depleted states.