Patent ID: 8242092
Filing Date: 2012-08-14
Classification: C12N,C12Y

Abstract:
1. A method of reducing the enzymatic activity of a human protein tyrosine phosphatase comprising contacting said human protein tyrosine phosphatase with an effective amount of nucleic acid ligand which exhibits binding specificity to a human protein tyrosine phosphatase, wherein the human protein tyrosine phosphatase is PTP1B, and wherein said nucleic acid ligand has a predicted secondary structure comprising a hairpin structure comprising a first region of paired nucleotides, a bulge, a second region of paired nucleotides and an end loop, wherein said bulge is located between said first and second region of paired nucleotides, and wherein said bulge is separated from said end loop by said second region of paired nucleotides, and wherein the nucleic acid ligand comprises a sequence exhibiting at least 70% sequence identity to a sequence chosen from SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9 and SEQ ID NO:10.