Patent ID: 6235732
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula I ##STR16##or a pharmaceutically acceptable salt thereof, whereinA is Ar, Ar--CH(Ph)--, Ar--(CH.sub.2).sub.2 --, Ar--CH(Ph)--CH.sub.2 --, Ar--CH.sub.2 --CH(Ph)--, or Ar--CH(Ph)--CH(Ph)--, wherein Ar is phenyl optionally substituted by one to three R.sup.4 groups, naphthyl, pyridyl, or thienyl; andPh is phenyl optionally substituted by one to three R.sup.4 groups;R.sup.4 is independently (C.sub.1-6)alkyl, (C.sub.1-6)alkyl substituted by 1 to 3 fluorine atoms, (C.sub.1-6)alkoxy, (C.sub.1-6)alkylthio or halogen; or two adjacent R.sup.4 groups together are --O--(CH.sub.2)--O --or --(CH.sub.2).sub.3-5 --;B is --CH(R.sup.12)--, --CH.sub.2 --CH.sub.2 --, --C(O)--, --C(O)--NH--, --C(O)--CH.sub.2 -- or --C(O)--CH.sub.2 --CH.sub.2 --;whereinR.sup.2 is H or CH.sub.3 ;R.sup.1 is H, (C.sub.1-6)alkyl, or phenyl;R.sup.2 is H, (C.sub.1-6)alkyl, or --C(O)(C.sub.1-3)alkyl, wherein the alkyl groups contained therein may be substituted by a phenyl group;R.sup.3 is hydrogen, (C.sub.1-6)alkyl, (C.sub.1-6)alkyl substituted by 1 to 3 fluorine atoms, halogen or (C.sub.1-6)alkoxy;m is 1, 2, or 3;Z is ##STR17##whereinR.sup.9 is hydrogen, (C.sub.3-7)cycloalkyl, phenyl, ##STR18##(C.sub.1-6)alkyl, allyl, --(CH.sub.2).sub.2-6 OH, --(C.sub.1-3)alkylphenyl, diphenylmethyl radical, or --(C.sub.1-3)alkyl(C.sub.3-7)cycloalkyl, wherein the phenyl groups contained in the above-mentioned groups are unsubstituted or substituted by one or two substituents selected from CH.sub.3, F, Cl, OCH.sub.3, SCH.sub.3, CF.sub.3, OH, or NO.sub.2, or they are substituted by --O--CH.sub.2 --O-- linked to 2 adjacent carbon atoms of the phenyl;or R.sup.9 is --CH.sub.2 OH, --OH, ##STR19##wherein the last six groups mentioned are in position 3, and wherein R.sup.14 is H, (C.sub.1-6) alkyl, phenyl, or cyclohexyl,wherein if one of the R.sup.14 groups is phenyl or cyclohexyl, the other R.sup.14 must be hydrogen; with the proviso that when:B is --CH.sub.2 --, R.sup.1 is H, alkyl, or phenyl, R.sup.2 is H, then Z is not ##STR20##