Patent ID: 8062638
Filing Date: 2011-11-22
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method for suppressing hypertrophy of the vascular intima caused by expression of tissue factor in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of an antibody that upon binding to human tissue factor (human TF), the antibody binds to an inhibitory site for binding a complex human TF and Factor VIIa to Factor X, wherein the antibody is a humanized antibody of version b-b, i-b, or i-b2, wherein said humanized antibody version has, respectively, the heavy and light chain pairings of SEQ ID NO: 29 and SEQ ID NO: 88 for version b-b; SEQ ID NO: 59 and SEQ ID NO: 88 for version i-b; and SEQ ID NO: 59 and SEQ ID NO: 98 for version i-b2, and wherein there is a constant region and the constant region is a constant region of human IgG.