Patent ID: 9126914
Filing Date: 2015-09-08
Classification: C07C,C07D

Abstract:
1. A method for the preparation of a compound of formula (XXI): the method comprises two steps, the two steps are a step (Q1) and a step (Q2); step (Q1) comprises a reaction (Q1-reac); reaction (Q1-reac) is a reaction of a compound of formula (XXV) with a reagent (Q1-reag) to provide a reaction product of reaction (Q1-reac); R1 is Br, Cl, or I; reagent (Q1-reag) is selected from the group consisting of lithium, magnesium, aluminum, zinc, calcium, propylmagnesium chloride, propylmagnesium bromide, butyllithium and mixtures thereof; step (Q2) comprises a reaction (Q2-reac); reaction (Q2-reac) is a reaction of the reaction product of reaction (Q1-reac) with chloroacetone to provide a reaction product of reaction (Q2-reac); the reaction product of reaction (Q2-reac) is a compound of formula (XXII); which is converted to a compound of formula (XXI).