Patent ID: 8551920
Filing Date: 2013-10-08
Classification: C07K,C40B

Abstract:
1. A method for identifying an antibody or fragment thereof that binds to a carbohydrate comprising: a) providing a protein library comprising a plurality of diverse antibodies or fragments thereof, wherein said antibodies or fragments thereof comprise a heavy chain variable domain sequence and a light chain variable domain sequence, wherein said heavy chain variable domain sequence comprises diversity in HC CDR3, and wherein each antibody or fragment thereof comprises an HC CDR3 comprising (G/S)-X-(K/R)-X-(K/R)-X (SEQ ID NO:3), wherein X is varied among a set of amino acids that exclude basic amino acids; b) contacting said protein library to a carbohydrate; and c) identifying one or more antibodies or fragments thereof that binds to said carbohydrate, wherein the protein library comprises at least 10