Patent ID: 8940749
Filing Date: 2015-01-27
Classification: C07D

Abstract:
1. A process for preparing 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one Palmitate ester of Formula V comprising the steps of: combining 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one with a fatty acid derivative in the presence of a pyridine derivative, at least one base and at least one organic solvent to obtain a reaction mixture; and adding an acid halide to the reaction mixture and maintaining the mixture for sufficient time to give the compound 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one Palmitate ester of Formula V.