Patent ID: 8263121
Filing Date: 2012-09-11
Classification: A61K,A61P

Abstract:
1. A multiple-layer tablet comprising (1) a layer containing pioglitazone hydrochloride having a median size of 1 to 50 μm and (2) a layer containing (a) metformin hydrochloride having a median size of 10 to 100 μm, (b) microcrystalline cellulose having a mean particle size of 5-25 μm, (c) microcrystalline cellulose having a mean particle size of 30-100 μm and (d) polyvinylpyrrolidone K-90 in an amount of 0.1-20 parts by weight per 100 parts by weight of the multiple-layer tablet, wherein the release of metformin hydrochloride is delayed compared to release of pioglitazone hydrochloride.