Patent ID: 8440393
Filing Date: 2013-05-14
Classification: A61P,C12N,C12Q

Abstract:
1. A method of diagnosing an epithelial ovarian tumor with a poor prognosis in a subject, comprising: contacting a sample containing ovarian tissue, ovarian cells or ovarian endothelial cells obtained from the subject with the epithelial ovarian tumor with a wild-type Zeste homologue 2 (EZH2) nucleic acid molecule or an anti-wild-type EZH2 antibody; comparing expression of wild-type EZH2 detected in the sample obtained from the subject with the epithelial ovarian tumor to a control; and detecting an at least 2-fold increase in expression of wild-type EZH2 relative to a control indicates the subject has a poor prognosis, thereby diagnosing the epithelial ovarian tumor in a subject with a poor prognosis.