Patent ID: 6368608
Filing Date: 2002-04-09
Classification: A61K,A61P,A61Q,C07C,C07D,Y10S

Abstract:
A method for treating a keratinization disorder, a dermatological disorder, an ophthalmological disorder, skin aging, epidermal and/or dermal atrophy, a cicatrization disorder, a sebaceous function disorder, a cancerous or precancerous disease state, inflammation, a viral infection, alopecia, a cardiovascular disorder, an immune deficiency, a rheumatic disorder, or a respiratory disorder, in a mammalian organism in need of such treatment, comprising administering to such organism a therapeutically effective amount of a pharmaceutical composition of matter which comprises a therapeutically effective amount of a polyaromatic propynyl compound or a pharmaceutically acceptable salt or isomer thereof, wherein the polyaromatic propynyl compound has the structural formula (I): in which X is one of the radicals: Ar is a radical of the following formula (a): R1 is (i) a hydrogen atom, (ii) a radical â€”CH 3, (iii) a radical â€”CH 2â€”Oâ€”R6, (iv) a radical â€”Oâ€”R6, (v) a radical â€”COâ€”R7, or (vi) a radical â€”S(O)tR9; R2 and R3 form, with the carbon atoms from which they depend, a 5- or 6-membered ring optionally substituted by methyl groups and/or optionally interrupted by an oxygen or sulfur atom; R4 is a hydrogen atom, a halogen atom, a lower alkyl radical or a radical â€”OR6; R5 has the definition of R4, and R4 and R5 may be identical or different; R6 is a hydrogen atom, a lower alkyl radical or a radical â€”COâ€”R9 and further wherein the radicals R6 may be identical or different; R7 is (a) a hydrogen atom, (b) a lower alkyl radical, (c) a radical of the formula: or a (d) a radical â€”OR8 wherein R8 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, an alkenyl radical, a mono- or polyhydroxyalkyl radical, or a phenyl, benzyl or phenethyl radical, which are optionally substituted by at least one halogen atom, or a hydroxyl or nitro functional group; R9 is a lower alkyl radical; R10 is a hydrogen atom, a lower alkyl radical, or a radical â€”OR6; R11 is a radical â€”OR6; Râ€² and Râ€³, which may be identical or different, are each a hydrogen atom, a lower alkyl radical, a mono or polyhydroxyalkyl radical or a phenyl radical optionally substituted by at least one halogen atom, or a hydroxyl or nitro functional group, or Râ€² and Râ€³ together with the nitrogen atom attached may form a piperidino, morpholino, pyrrolidino or piperazino radical which are optionally substituted at the 4-position by a C1-C6 alkyl radical or a mono- or polyhydroxyalkyl radical; t is an integer equal to 0, 1 or 2; and the radicals R10 and R11 may together form a single oxo group of the forumla=O; or pharmaceutically/cosmetically acceptable salt or optical or geometric isomer thereof.