Patent ID: 6872727
Filing Date: 2005-03-29
Classification: A61P,C07D

Abstract:
1. A method of inhibiting collagenase/MMP activities in a mammal comprising administering to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions with the general structures Ia and Ib, where: R R R Alk is C R n is 0, 1 or 2; Alk* is C X is mercapto or hydroxyaminoacylalkylthio (—SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene ring, R as well as the tautomers and pharmacologically relevant salts of these compounds.