Patent ID: 6878699
Filing Date: 2005-04-12
Classification: A61K,C07J

Abstract:
1. A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype, said method comprising contacting a hyperproliferative mammalian cell having a multiple drug resistant phenotype with an amount of a taccalonolide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arrest cell mitosis, thereby inhibiting the proliferation of the cell, wherein said taccalonolide has the structure: wherein: R R R R R R R R R R R R R R R R R R X=O, and wherein the dashed lines between C2/C3, C6/C7, C11/C2 and C22/23 represent optional double bonds at each position.