Patent ID: 6818886
Filing Date: 2004-11-16
Classification: G01N,H01J

Abstract:
A method for detecting a substance or substances in a sample or in a matrix of samples, comprising the steps of:(a) separating the substance or substances to be detected from the sample or matrix of samples with one of an integrated optical (bio)chemo-sensitive sensor-chip plate, of an integrated optical (bio)chemo-sensitive micro-array and of an integrated optical (bio)chemo-sensitive lab-on-chip, wherein each of said integrated optical (bio)chemo-sensitive sensor-chip plate, of said integrated optical (bio)chemo-sensitive micro-array and of said integrated optical (bio)chemo-sensitive lab-on-chip comprises at least one (bio)chemo-sensitive waveguide grating structure unit or (bio)chemo-sensitive sensor location; (b) detecting during or after the separation the substance or the substances with the help of a light wave, said light wave having an evanescent field and being at least partly guided in a waveguide structure; (c) detecting the substance or the substances or substance parts on selected (biochemo-sensitive waveguide grating structure units or on selected (bio)chemo-sensitive sensor locations by desorption and ionization of the substance or the substances or the substance parts with the help of a mass spectrometer.