Patent ID: 7402703
Filing Date: 2008-07-22
Classification: C07F

Abstract:
1. A process for a Zr-mediated hydroboration of alkynes comprising: reacting a substituted terminal alkyne of formula (I) with a compound of formula II: Without a solvent or in an inert solvent in the presence of bis(cyclopentadienyl)zirconium chloride hydride and an amine at temperatures of about 20-150° C., to obtain a compound of formula (III): wherein: X is a divalent group comprising an alkyl, an aryl or a heteroaryl; R Y is a H, an alkyl, an alkenyl, an aryl or heteroaryl, halogen, CN, NH m=0-2; R R Q is NZZ′ or N(O)ZZ′; Z and Z′ may be the same or different group comprising, a H, an alkyl, an alkenyl, an aryl or heteroaryl, wherein Z and Z′ taken together with the nitrogen to which they are attached may form a heterocyclic ring.