Patent ID: 8357665
Filing Date: 2013-01-22
Classification: A61K,A61P,C12N

Abstract:
1. An immune regulatory oligonucleotide (IRO) compound comprising at least two oligonucleotides linked by a non-nucleotide linker at their 3′ ends or by a functionalized sugar or by a functionalized base via a non-nucleotide linker, wherein at least one oligonucleotide has the structure wherein: CG is an oligonucleotide motif that is CpG, C*pG, C*pG* or CpG*, wherein C is cytosine, C* is a pyrimidine nucleotide derivative, G is guanosine, and G* is a purine nucleotide derivative; N N N N and further provided that the compound contains less than 3 consecutive guanosine nucleotides; wherein the oligonucleotide motif would be immune stimulatory but for the one or more modified nucleosides that suppress the activity of the oligonucleotide motif; wherein m is a number from 0 to about 30; wherein the IRO is an antagonist of an agonist of TLR7, TLR8 and/or TLR9; and provided that the at least two oligonucleotides are not antisense oligonucleotides.