Patent ID: 6017941
Filing Date: 2000-01-25
Classification: A61K,A61P

Abstract:
A method of treating leukemia in a subject in need of such treatment, comprising administering to said subject a compound of Formula IA or a physiologically acceptable salt thereof: ##STR11## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, alkylaryl, hydroxyalkyl, aminoalkyl, or alkylaminoalkyl, or R.sub.1 and R.sub.2 together represent a C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene or R.sub.1 and R.sub.2 together are: ##STR12## wherein n is a number from 1 to 3, and R.sub.10 is H or --CONHR.sub.11 NR.sub.15 R.sub.16, wherein R.sub.11 is lower alkyl and R.sub.15 and R.sub.16 are each independently selected from the group consisting of H and lower alkyl; andR.sub.3 is H, hydroxy, lower alkyl, cycloalkyl, aryl, alkylaryl, alkoxyalkyl, hydroxycycloalkyl, alkoxycycloalkoxy, hydroxyalkyl, aminoalkyl or alkylaminoalkyl; andR.sub.4 and R.sub.5 are each independently selected from the group consisting of H, lower alkyl, halogen, aryl, arylalkyl, aminoalkyl, aminoaryl, oxyalkyl, oxyaryl, or oxyarylalkyl;in an amount effective to treat leukemia.