Patent ID: 9034341
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,C12P

Abstract:
1. A composition comprising an amount of a fusion protein, wherein the fusion protein comprises a RAGE polypeptide linked to an immunoglobulin polypeptide, a) wherein the RAGE polypeptide comprises a fragment of human RAGE (SEQ ID NO: 3) wherein the fragment of human RAGE comprises a ligand binding site and at least one amino acid residue that may be glycosylated, b) wherein the immunoglobulin polypeptide comprises a C c) wherein the N-terminal residue of the immunoglobulin polypeptide is linked to the C-terminal residue of the RAGE polypeptide; and wherein at least 0.5% of the amount of the fusion protein is aglycosylated and wherein no more than 53.2% of the amount of the fusion protein is aglycosylated.