Patent ID: 7402568
Filing Date: 2008-07-22
Classification: C07H

Abstract:
1. A compound represented by formula (I) or (II): as well as the pharmaceutically acceptable salts, and esters thereof, wherein V is selected from the group consisting of: (a) —CH (b) —CH (c) —CH═C(A)-CH(B)-CH (d) —CH (f) —CH (g) —C(R or, alternatively, R 14 and R 15 taken together with the carbon atom to which they are attached are: (i) C═O; (ii) C(OR (iii) C(SR (iv) C═CHR (v) C═N—O—R (vi) C═NNHR (vii) C═NNHC(O)R (viii) C═NNHC(O)NHR (ix) C∇NNHS(O) (x) C═NNHR (xi) C═NR (h) —CH G and W are independently selected from: (a) hydrogen; (b) R (c) —C(O)R (d) —C(O)O—R (e) —C(O)N(R Or, alternatively, G and W are taken together to form either a carbonyl or a methylene group, L is: (a) —CH (b) —CH(OH)CH (c) -R D is —N(R 19 )CH 2 —, —N(R 20 )C(O)—, or —N═C(OR 20 )—, wherein R 20 is R 9 where R 9 is as previously defined; R 19 is (a) hydrogen; (b) —C Alternatively, D when taken together with G to form a moiety of the following structure: wherein L, V, W and R 2 ′ are as previously defined and P is C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of: a) R b) R c) heterocycloalkyl, d) hydroxyl, e) C1-C6-alkoxy, f) Halogen, and g) NR X is hydrogen; Y is (a) hydrogen; (b) —OH; (c) —OR (d) —OR (e) —OC(O)R (f) —OC(O)NHR (g) —S(O) where R 3 ″ is selected from hydrogen or methyl and R 4 ″ is selected from: (1) hydrogen; (2) R (3) —C(O)(CH Alternatively, X and Y taken together are oxo; Z is (a) hydrogen; (b) methyl; or (c) halogen; and R 2 ′ is hydrogen or R p , where R p , is as previously defined.