Patent ID: 8762070
Filing Date: 2014-06-24
Classification: A61B,G16H

Abstract:
1. A zone model predictive control (MPC) method of continuous monitoring and delivery of an insulin or insulin analog to a subject comprising: utilizing a linear difference model in combination with a model predictive control (MPC) algorithm to control delivery of the insulin or insulin analog within a zone of desired values, wherein the linear difference model and MPC algorithm are implemented, using sufficiently programmed computer, according to steps: obtaining insulin and meal data values and continuous glucose monitoring (CGM) data values for the subject; mapping the data using transfer functions: generating a linear difference model comprising a plurality of states: obtaining a defined glycemic zone for the subject; calculating a next administration dose and/or time of delivery of the insulin or insulin analog based on a predicted glycemic value for the subject using the linear difference model and the defined glycemic zone; and delivering the insulin or insulin analog to the subject based upon the calculated next insulin administration, wherein: I and M are insulin and meal data values expressed as amounts of insulin and carbohydrates, respectively, I τ s is a variable in unit of inverse time, G is glucose blood concentration, k is a time instant, α d p, q γ