Patent ID: 6951574
Filing Date: 2005-10-04
Classification: A61K,A61Q,C07C,C07D

Abstract:
1. A process for the preparation of a compound of formula (1) said process comprising the steps of: (a) reductively aminating a compound of formula (2): with a reagent of the formula R 1 R 2 NH and a reducing agent to produce a compound of formula (3) and (b) subjecting the compound of formula (3) to catalytic hydrogenation to produce a compound of formula (1) wherein R 1 and R 2 are each individually selected from the group consisting of hydrogen atoms, C 1 to C 5 alkyl, C 1 to C 5 mono or dihydroxyalkyl, phenyl or benzyl optionally substituted with a hydroxyl, amino or C 1 to C 3 alkoxy group, or R 1 and R 2 together with the nitrogen atom to which they are attached form a C 3 to C 6 saturated or unsaturated ring optionally containing in the ring one or more additional hetero atoms selected from O, S and N atoms.