Patent ID: 6331553
Filing Date: 2001-12-18
Classification: A61P,C07C,C07D

Abstract:
A compound represented by formula (1), or a tautomer, stereoisomer or optically active form of the compound or a pharmaceutically acceptable salt thereof ##STR681##where R.sub.1 and R.sub.2, which may be the same or different, are each a hydrogen atom, an optionally substituted lower alkyl group, an acyl group or a lower alkoxycarbonyl group, or R.sub.1 and R.sub.2 may combine together to form a 3- to 8-membered ring;R.sub.3 and R.sub.4, which may be the same or different, are each a hydrogen atom, an optionally substituted lower alkyl group, or R.sub.3 and R.sub.4 may combine together to form a monocyclic or fused ring having 3-10 carbon atoms;R.sub.5 is a hydrogen atom, a lower alkyl group, an acyl group or a lower alkoxycarbonyl group;X.sub.1, X.sub.2, X.sub.3, and X.sub.4 which may be the same or different are each a hydrogen atom, a halogen atom, a nitro group, a cyano group, a hydroxyl, group, an optionally substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkylthio group, a phenyl group optionally substituted by a halogen atom and/or a lower alkyl group, NX.sub.5 X.sub.6 or C(.dbd.O)X.sub.7 ;where X.sub.5 and X.sub.6, which may be the same or different, are each a hydrogen atom, an optionally substituted lower alkyl group, an acyl group, an optionally substituted lower alkoxycarbonyl group, or X.sub.5 and X.sub.6 may combine together to form a 3- to 8-membered ring;X.sub.7 is a hydrogen atom, a hydroxyl group, an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, or NX.sub.8 X.sub.9 ;where X.sub.8 and X.sub.9, which may be the same or different, are each a hydrogen atom, an optionally substituted lower alkyl group, or X.sub.8 and X.sub.9 may combine together to form a 3- to 8-membered ring;A is a substituted benzene ring or a 5- or 6-membered aromatic hetero ring which is optionally substituted and which contains at least one nitrogen atom as a hetero atom;n and m are each an integer of 0 or 1, with the proviso that when A is a substituted benzene ring the substituent(s) of which is (are) a nitro group, an amino group or a carboxyl group, either of R.sub.1 or R.sub.2 is a hydrogen atom, and that when A is a substituted benzene, the substituent is not a di-(3-chloroethyl)amino group, and that when A is a pyridine ring substituted by a nitro group, none of X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are a hydroxyl group.