Patent ID: 6716628
Filing Date: 2004-04-06
Classification: A61K,A61P,C07D

Abstract:
A method of producing a chondrocyte-containing composition comprising culturing a chondrocyte and/or a chondrocyte precursor in the presence of a compound represented by the general formula (I) or a salt thereof: whereinR1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group with an optional substituent; R2 represents a hydrogen atom, a lower alkyl group with an optional substituent, a lower alkenyl group with an optional substituent, a lower alkynyl group with an optional substituent, a lower alkoxy group with an optional substituent, an acyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent; R3 represents a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent; R4 represents a hydrogen atom, a lower alkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, â€”OR5, â€”SR5 or â€”NR6NR7 wherein R5, R6 and R7 may be the same or different and each represents a hydrogen atom, a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, a lower alkoxy group or an amino group with an optional substituent, and R6 and R7 may together form a group represented by â€”(CH2)mâ€” or â€”(CH2)lNR8(CH2)kâ€” wherein k, l and m each represents an integer of 1-8 and R8 represents a hydrogen atom or a lower alkyl group; X and Y may be the same or different and each represents â€”CH2â€”, â€”NHâ€” or â€”Oâ€”; and n represents an integer of 0-4.