Patent ID: 8188094
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein: R R R A represents A represents B represents H or methyl; and wherein the compound is not one selected from the group consisting of: N-[3-(1H-imidazol-1-yl)propyl]-6-phenyl-2-(3-pyridinyl)-4-pyrimidinamine; 6-(5-bromo-3-pyridinyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-6-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-(1H-pyrazol-1-yl)-2-(2-thienyl)-4-pyrimidinamine; 2-(2-furanyl)-N-[3-(1H-imidazol-1-yl)propyl]-6-(1H-pyrazol-1-yl)-4-pyrimidinamine; 2-(3-chloro-4-fluorophenyl)-6-ethyl-N-[3-(1H-imidazol-1-yl)propyl]-4-pyrimidinamine; 2-(4-bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-6-methyl-4-pyrimidinamine; 2-(4-chlorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-6-phenyl-4-pyrimidinamine; 2-(4-bromophenyl)-6-ethyl-N-[3-(1H-imidazol-1-yl)propyl]-4-pyrimidinamine; 6-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2,6-di-4-pyridinyl-4-pyrimidinamine, N-[3-(1H-imidazol-1-yl)propyI]-2-(3-pyridinyl)-6-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-(2-pyridinyl)-6-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-6-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-(3-pyridinyl)-2-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2,6-di-3-pyridinyl-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-(2-pyridinyl)-6-(3-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-6-(2-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-6-(3-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-6-(2-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-6-(3-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-phenyl-2-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-(4-pyridinyl)-6-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-(2-pyridinyl)-2-(4-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-(3-pyridinyl)-6[3-(trifluoromethyl)phenyl]-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-(2-pyridinyl)-2-(3-pyridinyl)-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-6-phenyl-2-(2-pyridinyl)-4-pyrimidinamine N-[3-(1H-imidazol-1-yl)propyl]-2-(2-pyridinyl)-6-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2,6-di-2-pyridinyl-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-6-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine; N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-6-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine; 6-(2-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-(4-pyridinyl)-4-pyrimidinamine; 6-(2-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-(3-pyridinyl)-4-pyrimidinamine; 6-(2-fluorophenyl)-N-[3-(1H-imidazol-1-yl)]-2-(2-pyridinyl)-4-pyrimidinamine; 6-(2-fluorophenyl)-N-[3-(1H-imidazol-1-yl)]-2-phenyl-4-pyrimidinamine; 6-(2-fluorophenyl)-N-[3-(1H-imidazol-1-yl)]-2-methyl-4-pyrimidinamine; 6-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)]-2-(4-pyridinyl)-4-pyrimidinamine; 6-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)]-2-(3-pyridinyl)-4-pyrimidinamine; 6-(5-bromo-3-pyridinyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-methyl-4-pyrimidinamine; 6-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-(2-pyridinyl)-4-pyrimidinamine; 6-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-2-phenyl-4-pyrimidinamine; and N-[3-(1H-imidazol-1-yl)propyl]-6-(methoxymethyl)-2-(2-thienyl)-4-pyrimidinamine.