Patent ID: 9108986
Filing Date: 2015-08-18
Classification: B01J,C07B,C07D,C07F

Abstract:
1. A method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines, comprising reducing a quinoline compound represented by formula [I]: wherein R R R n is an integer of 1 to 4, and when n is not less than 2, R in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]: (wherein R wherein X represents Cl wherein R wherein the hydrogen donor compound is formic acid, ammonium formate, sodium formate, potassium formate or 2-propanol, wherein the iridium(III) complex is isolated and purified by crystallization.