Patent ID: 6316450
Filing Date: 2001-11-13
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a salt thereof: ##STR4##wherein:P is phenyl, or naphthyl;A is a single bond, a C.sub.1-6 alkylene or a C.sub.1-6 alkenylene group;B is SO.sub.2 ;R.sup.1 is halogen, C.sub.1-6 alkyl optionally substituted by one or more fluorine atoms, C.sub.3-6 cycloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkanoyl, C.sub.1-6 alkoxy, OCF.sub.3, hydroxy, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkoxy, nitro, cyano, NR.sup.10 R.sup.11 where R.sup.10 and R.sup.11 are independently hydrogen, C.sub.1-6 alkyl or optionally substituted phenyl, SR.sup.11 where R.sup.11 is as defined above or R.sup.1 is optionally substituted phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur, or R.sup.1 together with a second R.sup.1 substituent forms a group --O--CH.sub.2 --O--, OCH.sub.2 CH.sub.2 O--, --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --,n is 0, 1, 2, 3, 4, 5 or 6;R.sup.2 is hydrogen, C.sub.1-6 alkyl, aryl C.sub.1-6 alkyl or together with group P form a 5 to 8 membered ring optionally substituted with one or more C.sub.1-6 alkyl groups;R.sup.3 is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkanoyl, C.sub.1-6 alkoxy optionally substituted with one or more fluorine atoms, hydroxy, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkoxy, nitro, trifluoromethyl, cyano or aryl or together with the group R.sup.5 forms a group (CH.sub.2).sub.2 O or (CH.sub.2).sub.3 O optionally substituted with 1 or more C.sub.1-6 alkyl groups;R.sup.4 is piperazine, optionally substituted by C1-6alkyl with a meta relationship with the group B; andR.sup.5 is methoxy with a para relationship to the group B.