Patent ID: 6340670
Filing Date: 2002-01-22
Classification: C07H

Abstract:
A compound of formula I having the structure whereinX is O or S; R1 alkyl of 1-6 carbons atoms, haloalkyl of 1-6 carbon atoms, nitroalkyl of 1-6 carbon atoms, cyanoalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, phenyl mono-, di-, or tri-substituted with R8, phenylalkyl of 7-10 carbon atoms, wherein the phenyl ring mono-, di-, or tri-substituted with R8, pyridyl substituted with R8, furyl substituted with R8, thienyl substituted with R8, and thiazolyl substituted with R8; R2 is hydrogen, acyl of 2-6 carbon atoms, haloacyl of 2-6 carbon atoms, nitroacyl of 2-7 carbon atoms, cyanoacyl of 2-7 carbon atoms, or trifluoromethylacyl of 3-8 carbon atoms, carboalkoxyacyl of 4-12 carbon atoms, R3, R4, R5, R6 are each, independently, hydrogen, acyl of 2-7 carbon atoms, benzoyl, wherein the phenyl moiety is mono-, di-, or tri-substituted with R8, haloacyl of 2-7 carbon atoms, nitroacyl of 2-7 carbon atoms, cyanoacyl of 2-7 carbon atoms, or trifluoromethylacyl of 3-8 carbon atoms; R7 is hydrogen; R8 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, phenyl, â€”CN, â€”NO2, halogen, or â€”CF3; R9 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, phenyl, â€”CN, â€”NO2, halogen, â€”CF3, â€”NHR3, â€”NR3R3, â€”NR3R14, â€”NHCO2R14, â€”NHSO2R14, R10, R11, R12, are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, phenyl, â€”CN, â€”NO2, halogen, â€”CF3, acyl of 2-7 carbon atoms, or benzoyl, wherein the phenyl group or the phenyl moiety of the benzoyl group is optionally mono-, di-, or tri-substituted with alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, â€”CN, â€”NO2, halogen, or â€”CF3; R13 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, â€”CN, â€”NO2, halogen, â€”CF3, or phenyl group, wherein the phenyl moiety is optionally mono-, di-, tri-substituted with alkyl 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or halogen; R14 is alkyl of 1-6 carbon atoms; R15 is hydrogen, acyl of 2-7 carbon atoms, benzoyl, or â€”CO2R16; R16 is alkyl of 1-6 carbon atoms, benzyl, phenyl, or fluorenyl; n=0-3; p=0-6; or a pharmaceutically acceptable salt thereof.