Patent ID: 7220762
Filing Date: 2007-05-22
Classification: A61K,A61P,C07D

Abstract:
1. A method for stabilizing a benzimidazole-based compound or a physiologically acceptable salt thereof, comprising incorporating by mixing together (1) a crospovidone, (2) sodium hydroxide, potassium hydroxide or a mixture thereof, and (3) a benzimidazole-based compound represented by the following Formula 1, or a physiologically acceptable salt thereof wherein Het and Het R thereby forming a uniform mixture of components (1), (2) and (3); wherein the benzimidazole-based compound (3) and the crospovidone (1) are incorporated with each other in a weight ratio of 0.5 to 5 part by weight to 1 part by weight of the benzimidazole-based compound and, wherein the sodium hydroxide or potassium hydroxide or their mixture (2) and the benzimidazole-based compound (3) are incorporated with each other in a weight ratio of 0.01 to 2 parts (2) to one part by weight of the benzimidazole-based compound (3) and, wherein the crospovidone (1) is present in an amount of more than 10 weight percent of the mixture.