Patent ID: 8211440
Filing Date: 2012-07-03
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of treating B-cell leukemia or B-cell lymphoma comprising administering to a subject with cancer a hexavalent stably tethered structure comprising: (i) an IgG antibody that binds to a tumor-associated antigen (TAA), wherein the IgG antibody attached to two AD moieties selected from the group of SEQ ID NO: 3 and 4; and (ii) four antigen-binding antibody fragments of the same or different IgG with each fragment attached to a DDD moiety selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2; the AD moieties bound to the DDD moieties.