Patent ID: 6262073
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A method for inhibiting the action of a pro-inflammatory cytokine in an animal patient comprising administering to said patient an effective amount of a pro-inflammatory cytokine action-inhibiting composition comprising an optically active or racemic compound of the formula: ##STR21##wherein R is hydrogen, phenyl, or a lower alkyl; L is a linker moiety selected from the group consisting of oxygen, sulfur, nitrogen, acetylene, a cis or trans carbon--carbon double bond, an ester, carbonate, urea, amide and carbamate; m is 0 or 1, n is 0 to 4, Aryl is a substituted or unsubstituted aryl group; with the proviso that when R is hydrogen, then either m or n is not zero; or a pharmaceutically acceptable salt thereof.