Patent ID: 8658639
Filing Date: 2014-02-25
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I): wherein R R G R R (wherein, R (a) hydrogen atom, (b) halogen atom, (c) cyano, (d) C 1-4 alkyl (optionally substituted by 5- to 6-membered saturated heterocyclyloxy, C 1-4 alkoxy (optionally substituted by C 1-4 alkoxy or C 3-6 alkoxy), or 1 to 3 fluorine atoms), (e) C 1-4 alkoxy (optionally substituted by 1 to 3 halogen atoms, C 1-4 alkoxy or C 1-6 alkylaminocarbonyl), (f) C 3-6 cycloalkoxy (optionally substituted by C 1-4 alkoxy), (g) 5- to 6-membered saturated heterocyclyloxy, (h) C 1-6 alkylaminocarbonyl, (i) hydroxyl, or (j) C 1-4 alkylsulfonyl, or R R (wherein D is oxygen, sulfur, —SO 2 —, —NR 4a —, —NR 4a CO—, —NR 4a SO 2 —, —NR 4a CONR 4a —, —CH(R 4b )—, or —CH(R 4b )CH 2 —, R R p and q are independently 0, 1 or 2); R R (wherein R 1z is hydrogen atom, halogen atom, C 1-4 alkyl or C 1-4 alkoxy, r is 1, 2, 3 or 4); R R (wherein A is a single bond, —(CH B is hydrogen atom, optionally substituted C provided that if A is —(CH R s is 0, 1 or 2, provided that if A is —(CH provided that if A is —(CH any two of R n is 0, 1 or 2; R 1: C (a) amino, (b) hydroxy, or (c) a group of the following formula: (wherein R (i) C (ii) C (iii) C 2: C (a) amino, or (b) hydroxy) 3: C (wherein R 4: a group of the following formula: (wherein R (a) hydrogen atom, (b) C (c) C (d) C (e) 5- to 6-membered saturated heterocyclyl, or (f) 5- to 10-membered monocyclic or polycyclic heteroaryl (optionally substituted by C (a) C (b) C (c)C (d) C (e) 5- to 10-membered monocyclic or polycyclic heteroaryl, (f) 5- to 6-membered saturated heterocyclyl(optionally substituted by C (g) C (h) C (i) 5- to 6-membered saturated heterocyclyloxy); or a pharmaceutically acceptable salt thereof.