Patent ID: 6075037
Filing Date: 2000-06-13
Classification: A61P,C07D

Abstract:
A compound of the formula Ia ##STR28## wherein: R.sub.1 is --X(CH.sub.2).sub.n Ar or cyclohexyl;R.sub.2 is a moiety of formula (a) or (b) or indolyl;P.sub.1 is CO.sub.2 H or tetrazole;P.sub.2 is hydrogen;R.sub.3 and R.sub.5 are independently hydrogen, R.sub.11, OH, C.sub.1-8 alkoxy, S(O).sub.q R.sub.11, N(R.sub.6).sub.2, Br, F, I, Cl, CF.sub.3, NHCOR.sub.6, --R.sub.12 CO.sub.2 R.sub.7, --XR.sub.9 --Y or --X(CH.sub.2).sub.n R.sub.8 ;R.sub.4 is hydrogen, R.sub.11, OH, C.sub.1-5 alkoxy, S(O).sub.q R.sub.11,N(R.sub.6).sub.2, --X(R.sub.11), Br, F,I, Cl or NHCOR.sub.6 wherein the C.sub.1-5 alkoxy may be unsubstituted or substituted by OH, methoxy or halogen;R.sub.6 is independently hydrogen or C.sub.1-4 alkyl;R.sub.7 is independently hydrogen, C.sub.1-6 alkyl or (CH.sub.2).sub.n Ar;R.sub.8 is hydrogen, R.sub.11, CO.sub.2 R.sub.7, PO.sub.3 H.sub.2, P(O)(OH)R.sub.7, CN, --C(O)N(R.sub.6).sub.2, tetrazole or OR.sub.6 ;R.sub.9 is C.sub.1-10 alkylene, C.sub.2-10 alkenylene or phenylene all of which may be unsubstituted or substituted by one or more OH, N(R.sub.6).sub.2, COOH, halogen or XC.sub.1-5 alkyl;R.sub.10 is R.sub.3 or R.sub.4 ;R.sub.11 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl all of which may be unsubstituted or substituted by one or more OH, CH.sub.2 OH, N(R.sub.6).sub.2 or halogen;R.sub.12 is C.sub.1-8 alkylene, C.sub.2-8 alkenylene or C.sub.2-8 alkylnylene;X is (CH.sub.2).sub.n, or O,;Y is CH.sub.3 or --CH.sub.2 X(CH.sub.2).sub.n Ar;Ar is: ##STR29## or naphthyl, indolyl, pyridyl, thienyl, oxazolidinyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, pyrrolyl, or pyrimidyl; all of which may be unsubstituted or substituted by one or more R.sub.3 or R.sub.4 groups:A is C.dbd.O, or (C(R.sub.6).sub.2).sub.m ;B is --CH.sub.2 -- or --O--;q is zero, one or two;n is an integer from 0 to six;m is 1, 2 or 3;and the dotted line indicates the optional presence of a double bond; or a pharmaceutically acceptable salt thereof; provided that when the optional double bond is present there is no P.sub.1 or R.sub.10.