Patent ID: 8802138
Filing Date: 2014-08-12
Classification: A61K,A61P,C12N

Abstract:
1. An RNAi Delivery and Expression System (RIDES) composition comprising: (a) a liposomal formulation, where the lipid component comprises DOTAP, Cholesterol, DOPE, and DSPE-PEG2000 in a molar ratio of about 50:30:19:1, wherein the charge ratio between RNAi agent and DOTAP is between 1:1 and 1:10, wherein the liposomal formulation further contains one or more enabler agents selected from the group consisting of paclitaxel, docetaxel, vincristine, colchicine, nocodazole, and doxorubicin, plus an RNA interference (RNAi) agent selected from the group consisting of small interfering RNA (siRNA), double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA); and (b) a pharmaceutically acceptable carrier.