Patent ID: 6326492
Filing Date: 2001-12-04
Classification: A61P,C07D

Abstract:
A compound having the Formula VII: ##STR32##or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:A is one of ##STR33##R.sup.1 is alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, aralkyl, thienyl, thienyl(C.sub.1-4)alkyl, quinolinyl, quinolinyl(C.sub.1-4)alkyl, imidazolyl, imidazolyl(C.sub.1-4)alkyl, pyridyl, or pyridyl(C.sub.1-4)alkyl, any of which may be optionally substituted;Z is --SO.sub.2 --,--OCO--,--CO--, --NR.sup.2 CO-- or a covalent bond,where R.sup.2 is hydrogen, alkyl, aralkyl, aryl, hydroxy(C.sub.2-10)alkyl, amino(C.sub.2-10)alkyl, monoalkylamino(C.sub.2-10)alkyl, dialkylamino(C.sub.2-10)alkyl or carboxyalkyl;Het is ##STR34##whereR.sup.3, R.sup.4 and R.sup.5 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamido, alkoxycarbonylmethyl, carboxymethyl, --CO.sub.2 R.sup.x, --CH.sub.2 OR.sup.x or --OR.sup.x,where R.sup.x, in each instance, is independently one of hydrogen, alkyl or cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations;R.sup.7 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 alkenyl;R.sup.a, R.sup.b and R.sup.c are independently hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano or --CO.sub.2 R.sup.w, whereR.sup.w is alkyl, cycloalkyl, phenyl, benzyl, ##STR35##whereR.sup.d and R.sup.e are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.f is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, R.sup.g is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl, and R.sup.h is aralkyl or C.sub.1-6 alkyl;each n is zero or 1;each m is zero or 1; andeach j is zero or 1;provided that n, m and j are not all zero.