Patent ID: 6800637
Filing Date: 2004-10-05
Classification: A61P,C07D

Abstract:
A compound of Formula I: X is O, N&boxH;CH, CR7&boxH;CH or CR7&boxH;N, in which R7 is hydrogen or alkyl of 1 to 6 carbon atoms; Z is O, S or NR8, in which R8 is hydrogen or alkyl of 1 to 6 carbon atoms; R1, R5 and R6 are, independently, hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyl of 2 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, alkanesulfonyl of 1 to 6 carbon atoms or alkanesulfonamido of 1 to 6 carbon atoms; R2 is hydrogen, halo, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms or alkyl of 1 to 6 carbon atoms; R3 and R4 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms; n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.