Patent ID: 7488725
Filing Date: 2009-02-10
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein: R R R R R R X is a methylene group or a bond, wherein the methylene group may be optionally substituted with one or two fluorine atoms; Y is a methylene group, wherein said methylene group may be optionally substituted with one or two fluorine atoms, or Y and Z together may optionally form a bond; Z is selected from a bond, —NR wherein A forms a 5 to 8 membered cycloheteroalkyl and B is a fused 5 to 7 member ring system selected from aryl and heteroaryl, wherein said ring system may be optionally be substituted with one to five groups selected from the group consisting of halo, C 1-6 alkyl, C 1-6 polyhaloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 polyhaloalkoxy, C 1-6 alkoxycarbonyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkylalkyl, polycycloalkyl, heteroarylamino, arylamino, cycloheteroalkyl, cycloheteroalkylalkyl, hydroxy, C 1-6 hydroxyalkyl, nitro, cyano, amino, C 1-6 alkylamino, C 1-6 dialkylamino, thiol, C 1-6 alkylthio, aminocarbonyl, C 2-6 alkynylaminocarbonyl, C 1-6 alkylaminocarbonyl, C 2-6 alkenylamino-carbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylcarbonylamino, arylcarbonylamino; heteroarylcarbonylamino, C 1-6 alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, C 1-6 alkylaminocarbonylamino, C 1-6 alkoxycarbonylamino, C 1-6 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, and sulfonamido; and n is 0-2.