Patent ID: 8623322
Filing Date: 2014-01-07
Classification: A61K,A61P,G01N,Y02A

Abstract:
1. A method of diagnosing the existence of an infectious disease which is mediated through ICAM-1/LFA-1 receptors in tissue of a patient in which levels of said receptors are suspected of being elevated comprising administering to said patient an effective amount of at least one compound according to the following chemical structure: where Y is a chemical linker which links the nitrogen to a chelate group or tricarbonyl complex X, wherein X incorporates or complexes with a radioisotope, or a pharmaceutically acceptable salt thereof, measuring the amount of said compound which binds to said tissue in said patient, and comparing said measurement from said measuring step with a standard, wherein an elevated measurement in comparison to said standard is indicative of the existence of said infectious disease in said patient and said infectious disease is a skin or soft tissue infection, a bone or joint infection, a central nervous system infection arising from meningococcal, an upper or lower respiratory tract infection, infective endocarditis, tuberculosis, a gasterointestinal infection, an intra-abdominal infection of the stomach, biliary tract, proximal small-bowel, distal ileum, or colon; primary or secondary bacterial peritonitis; an abscess; contamination from abdominal trauma, pelvic inflammatory disease, a parasitic disease, a urinary tract infection, prostatitis, urethritis, epididymitis, cervicitis or vulvovaginitis, proctitis, salpingitis, a fungal infection, a post-surgical infection, folliculitis, furuncles, carbuncles, erysipelas, lymphangitis, cellulitis, a necrotizing soft tissue infection, a diabetic foot infection, decubitus ulcers, mastoiditis, a meningococcal infection, a pneumococcal infection, a diplococcal infection, a