Patent ID: 7252931
Filing Date: 2007-08-07
Classification: C12Q,G01N,Y10T

Abstract:
1. A method for generating a combinatorial library of bi-ligand compounds that can simultaneously bind to a CL site and an SL site of an enzyme, wherein the enzyme binds a common ligand (CL) or a common ligand mimic (CL mimic) at a common ligand site (CL site) and binds a specificity ligand (SL) at an adjacent specificity ligand site (SL site); wherein an interface region is defined as the atoms of the enzyme between the CL site and SL site, and atoms of an SL, if bound to the enzyme; wherein the enzyme catalyzes a reaction involving the SL and a reactive atom of the CL; and wherein a CL reactive region is defined as the reactive atom of the CL and immediately adjacent atoms of the CL; comprising the steps of