Patent ID: 8535890
Filing Date: 2013-09-17
Classification: A61K,A61P,C07K

Abstract:
1. A method for determining the immunogenicity of a variant humanized CC49 antibody, comprising: contacting anti-idiotypic antibodies which bind a parental humanized CC49 antibody with the parental humanized CC49 antibody and with the variant humanized CC49 antibody; and determining the ability of the anti-idiotypic antibodies to bind the variant humanized CC49 antibody and the parental humanized CC49 antibody; wherein an at least five-fold higher molar concentration of the variant humanized CC49 antibody than the molar concentration of the parental humanized antibody being required to elicit 50% inhibition of the parental humanized CC49 antibody binding to the anti-idiotypic antibodies indicates that the variant humanized CC49 is minimally immunogenic, and wherein the parental humanized CC49 antibody comprises one of: