Patent ID: 9115052
Filing Date: 2015-08-25
Classification: C07B,C07C,Y02P

Abstract:
1. A process for separating an enantiomer mixture of (R)- and (S)-3-amino- 1 -butanol optionally protected on the oxygen atom, comprising the following steps: (i) reacting an enantiomer mixture of the compounds of the formulae I-R and I-S (ii) removing and isolating the (S)- or (R)-mandelic salt of the compound of the formula I-R formed in step (i); (iii) optionally purifying the (S)- or (R)-mandelic salt of the compound of the formula I-R isolated in step (ii); (iv) releasing the compound of the formula I-R from the (S)- or (R)-mandelic salt thereof and if desired deprotecting the compound of the formula I-R in which R (v) optionally releasing the enriched compound of the formula I-S and optionally deprotecting the compound of the formula I-S wherein R wherein the compound of the formula I-R is released from the (S)- or (R)-mandelic salt thereof in step (iv) by reacting the (S)- or (R)-mandelic salt of the compound of the formula I-R obtained in step (ii) or (iii) with a base selected from alkali metal C 1 -C 4 -alkoxides in a solvent which possesses a boiling point at least 10° C. higher than 3-amino-1-butanol and is selected from organic amines having a melting point of at most 50° C. and a boiling point of at least 180° C.