Patent ID: 7851640
Filing Date: 2010-12-14
Classification: C07D

Abstract:
1. A method of using a chiral thiourea catalyst for enantioselective synthesis of a chromanone compound, said method comprising: providing an alkylidene compound of a formula wherein R 1 is selected from substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkylalkenyl, aryl, and aralkyl moieties; R 2 is selected from substituted or unsubstituted branched chain about C 3 to about C 6 alkyl and about C 3 to about C 9 cycloalkyl moieties; R 3 , R 4 , R 5 , and R 6 are independently selected from H, OR 7 , substituted a unsubstituted alkyl and cycloalkyl moieties, and moieties where one of R 6 and R 5 together, R 5 and R 4 together, or R 4 and R 3 together form a substituted or unsubstituted C 3 to about C 5 alkylene or alkenylene moieties; and R 7 is selected from H and substituted or unsubstituted alkyl moieties; and contacting said compound with a chiral thiourea catalyst compound in an amount at least partially sufficient for intramolecular conjugate addition of said alkylidene compound, to provide a chromanone compound of a formula