Patent ID: 6608183
Filing Date: 2003-08-19
Classification: A61K,A61P,C07K

Abstract:
A cysteine variant of growth hormone of SEQ ID NO:1, wherein a cysteine residue is substituted for at least one amino acid located in at least one region of growth hormone selected from the group consisting of: the C-D loop, the first three or last three amio acids in helix A, the first three or last three amino acids in helix B, the first three amino acids in helix C, the first three o r last three a mno acids in helix D, the amino acids preceding helix A corresponding to amino acids 1-5 of SEQ ID NO:1, and the amino acids prclowing helix D corresponding to amino acids 184-191 of SEQ ID NO:1;wherein said variant has biological activity in vitro as measured by proliferation of a cell line that proliferates in response to growth hormone.