Patent ID: 8106029
Filing Date: 2012-01-31
Classification: A61K,A61P

Abstract:
1. A method of producing coronary vasodilation in a human in need thereof comprising administering to the human a single intravenous (iv) bolus dose of a pharmaceutical composition comprising: a) regadenoson, a compound named (1-{9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide, which has the formula: and b) at least one pharmaceutical excipient wherein the composition has a pH of from about 6 to about 8; wherein the single dose of the pharmaceutical composition is administered in an amount that is sufficient to increase the average coronary peak flow velocity by at least about 16.5 cm/sec to about 105 cm/sec.