Patent ID: 6019959
Filing Date: 2000-02-01
Classification: A61K,C07D

Abstract:
Oligomeric compounds that contain perfluoroalkyl of general formula I:A--R.sup.F (I)in whichA is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen atom of an annular skeleton chain, andR.sup.F is a perfluorinated, straight-chain or branched carbon chain with formula --C.sub.n F.sub.2n E, in which E represents a terminal fluorine, chlorine, bromine, iodine, or hydrogen atom and n stands for numbers 4-30,wherein molecule portion A has the following structure: ##STR23## whereby q is a number 0, 1, 2 or 3,K stands for a complexing agent or metal complex or their salts of organic and/or inorganic bases or amino acids or amino acid amides,X is a direct bond to the perfluoroalkyl group, a phenylene group, or a C.sub.1 -C.sub.10 alkylene chain, which optionally contains 1-15 oxygen atoms, 1-5 sulfur atoms, 1-10 carbonyl groups, 1-10 (NR) groups, 1-2 NRSO.sub.2 groups, 1-10 CONR groups, 1 piperidine group, 1-3 SO.sub.2 groups, 1-2 phenylene groups or optionally is substituted by 1-3 radicals R.sup.F, in which R stands for a hydrogen atom, a phenyl, benzyl or a C.sub.1 -C.sub.15 alkyl group, which optionally contains 1-2 NHCO groups, 1-2 CO groups, 1-5 oxygen atoms, and optionally is substituted by 1-5 hydroxy radicals, 1-5 methoxy radicals, 1-3 carboxy radicals, 1-3 R.sup.F radicals,Y is a direct bond or a chain of general formula II or III: ##STR24## in which R.sup.1 is a hydrogen atom, a phenyl group, a benzyl group or a C.sub.1 -C.sub.7 alkyl group, which optio nally is substituted with a carboxy group, a methoxy group, or a hydroxy group,Z is a direct bond, a polyglycol ether group with 1 to 5 glycol units, or a molecule portion of general formula IV--CH(R.sup.2)-- (IV)in which R.sup.2 is a C.sub.1 -C.sub.7 carboxylic acid, a phenyl group, a benzyl group, or a --(CH.sub.2).sub.1-5 --NH--K group,.alpha. represents the bond to the nitrogen atom of the skeleton chain, and .beta. is the bond to the complexing agent or metal complex K,and in which variables k and m stand for natural numbers between 0 and 10 and 1 stands for 0 or 1,and wherebyG is a CO or SO.sub.2 group.