Patent ID: 8796421
Filing Date: 2014-08-05
Classification: A61K,A61P,C07K,C12N,C12Q

Abstract:
1. An isolated polypeptide of human epidermal growth factor receptor variant de4 EGFR selected from the group consisting of: (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 2; (b) a polypeptide generated by a replacement of 1-10 amino acids, a deletion of 1-10 amino acids or an addition of less than 10 amino acids at the C-terminal end and/or the N-terminal end of SEQ ID NO: 2, which can promote tumor cell invasion and/or migration and is derived from (a); and (c) a polypeptide possessing ≧98% homology to the amino acid sequence of SEQ ID NO: 2, which can promote tumor cell invasion or migration and is derived from (a).