Patent ID: 6219576
Filing Date: 2001-04-17
Classification: A61N

Abstract:
A method of regulating an electrotransport system delivering a beneficial agent by supplying a load current across a first electrode and a second electrode, the method comprising the steps of:(a) generating a load current in accordance with a load current pattern; and(b) supplying the generated load current to the electrodes, wherein the supplied load current achieves a sought load current which is inversely proportional to an apparent transport efficiency of the beneficial agent when a constant beneficial agent delivery rate is maintained,(c) wherein the apparent transport efficiency of the beneficial agent isATE.sub.o *(1-exp.sup.(-K.sup..sub.ATE*t) )and the desired average current isi.sub.o *exp.sup.(-K.sup..sub.ATE*t)where ATE.sub.o and i.sub.o are an initial apparent transport efficiency and an initial sought load current, respectively, K.sub.ATE is a rate constant, and t is time,(d) wherein the load current is a pulsed current and the load current is adjusted by adjusting one of the magnitude, time, and the duty cycle of the pulse, and(e) wherein the method is implemented in an interchangeable circuit board or component.