Patent ID: 6284756
Filing Date: 2001-09-04
Classification: A61P,C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof, ##STR116##whereinA is carbonyl or methylene;D is CH, CR.sup.d or N in which R.sup.d is formyl, hydroxymethyl, methyl or methoxy;E is CH, CR.sup.e or N in which R.sup.e is methyl, methoxy or halo;R.sup.2 and R.sup.3 are defined together such thatA. R.sup.2 is --X.sup.2 --(CH.sub.2).sub.m --NR.sup.a R.sup.b in which X.sup.2 is a direct bond, methylene or O; m is 1, 2, 3, 4 or 5; provided that when m is 1, then X.sup.2 is a direct bond; and R.sup.a and R.sup.b are independently hydrogen or (1-3C)alkyl or the group NR.sup.a R.sup.b is pyrrolidino, piperidino, or morpholino; andR.sup.3 is --CH.sub.2 --R.sup.c, in which R.sup.c is 5-tetrazolyl, 2-carboxy-5-oxopyrrolidin-1-yl or 2-{{(1-4C)alkoxy}carbonyl}-5-oxopyrrolidin-1-yl; orR.sup.3 is --O--(CH.sub.2).sub.e --(CHCH.sub.3).sub.f --R.sup.f in which e is 0, 1, 2 or 3 and f is 0 or 1 and the sum of e and f is 1, 2 or 3 and R.sup.f is as defined below; orB. R.sup.2 is --X.sup.2 --(CH.sub.2).sub.n --R.sup.f in which X.sup.2 is a direct bond, methylene or O; n is 1, 2, 3 or 4; and R.sup.f is 5-tetrazolyl, carboxy, {(1-4C)alkoxy}carbonyl} or hydroxymethyl; andR.sup.3 is --X.sup.3 --(CH.sub.2).sub.s --NR.sup.s R.sup.t or --CH.sub.2 --R.sup.k, in which X.sup.3 is a direct bond, methylene or O; s is 1 or 2; provided that when s is 1, then X.sup.3 is a direct bond; and R.sup.s and R.sup.t are independently hydrogen or (1-3C)alkyl or the group NR.sup.s R.sup.t is pyrrolidino, piperidino, or morpholino; and R.sup.k is 2-oxopyrrolidin-1-yl or 3-(1-oxoethyl)imidazolidin-1-yl; andone of R.sup.5 and R.sup.6 is hydrogen; and the other of R.sup.5 and R.sup.6 is hydrogen, hydroxy or methoxy.