Patent ID: 6066663
Filing Date: 2000-05-23
Classification: A61K,A61P,A61Q,C07D

Abstract:
A compound of general formula I ##STR6## in which: ##STR7## is selected from the group consisting of: ##STR8## n is equal to 1, 2 or 3; R1, R2, R3 and R4 represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl, cycloalkyl, lower alkoxy, aryloxy, lower aralkoxy, lower perhaloalkyl, lower perhaloalkoxy, or nitro group or an unsaturated aliphatic chain; orwherein R1 and R2, R2 and R3, and R3 and R4 form part of another aromatic or non-aromatic ring containing at least 5 atoms, wherein the ring optionally contains several hetero atoms and is optionally substituted with one or more groups that represent, independently of each other, a hydroxyl group, a lower alkyl, lower alkoxy, aryloxy, lower aralkoxy, or nitro group, a halogen atom, or an unsaturated aliphatic chain;R5 represents a hydrogen atom, a lower alkyl, aryl or lower aralkyl group, each optionally substituted with one or more halogens, an amino, (lower) alkyl-amino or (lower) dialkyl-amino, arylalkylamino, aralkylamino, or diaralkylamino group, or a lower alkoxy, (lower) alkyloxycarbonyl, aryloxycarbonyl or aralkyloxycarbonyl group;R6 and R8 represent, independently of each other, a hydrogen atom, a halogen atom, or a lower alkyl, aryl, lower aralkyl, lower alkoxy, aryloxy, lower aralkoxy, lower perhaloalkyl, (lower) perhaloalkyl-carbonyloxy, alkylsulphonyl, arylsulphonyl, aralkylsulphonyl, or (lower) perhaloalkylsulphonyl group;W and R7 represent, independently of each other, an oxygen atom or a sulphur atom;R9 represents a lower alkyl, aryl, or aralkyl group, optionally substituted with one or more halogens, an alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, (lower) perhaloalkyl-carbonyl, or perhaloaralkylcarbonyl group, or a (lower) alkyl-sulphonyl, arylsulphonyl, aralkylsulphonyl, (lower) perhaloalkyl-sulphonyl or perhaloaralkylsulphonyl group; or wherein R5 and R6, R5 and R8, R6 and R8, and R8 and R9 are linked to form a saturated or unsaturated ring containing at least 5 atoms, wherein the ring optionally contains several hetero atoms and is optionally substituted with one or more groups, which represent, independently of each other, a hydroxyl group, a lower alkyl, lower alkoxy, aryloxy, lower aralkoxy, or nitro group, a halogen atom, or an unsaturated aliphatic chain;their racemic mixtures, their pure enantiomers or their mixtures in all proportions, and their therapeutically acceptable salts.