Patent ID: 7252935
Filing Date: 2007-08-07
Classification: C12Q

Abstract:
1. A method for indicating an increased likelihood of prostate adenocarcinoma comprising: determining a methylation ratio of a tissue sample from a human subject with early stage cancer, wherein the methylation ratio is the level of methylation of a bisulfite-treated promoter region of glutathione-S-transferase (GSTP1) relative to a level of bisulfite-treated DNA copy number of a reference gene, wherein the early stage cancer is localized prostate cancer, wherein the reference gene is MYOD or ACTB, wherein a methylation ratio higher than the methylation ratio in tissue from a normal subject is indicative of prostate adenocarcinoma in the subject, and wherein a methylation ratio times 1000 of greater than about 3 is indicative of prostate adenocarcinoma in the subject.