Patent ID: 7105548
Filing Date: 2006-09-12
Classification: A61P,C07D

Abstract:
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein X is aryl and Y is pyridyl; X is optionally substituted with 1–7 independent halogen, —CN, NO R1, R2, and R3 each independently is —C0–6alkyl, —C3–7cycloalkyl, heteroaryl, or aryl; any of which is optionally substituted with 1–5 independent halogen, —CN, —C1–6alkyl, —O(C0–6alkyl), —O(C3–7cycloalkyl), —O(aryl), —O(heteroaryl), —N(C0–6alkyl)(C0–6alkyl), —N(C0–6alkyl)(C3–7cycloalkyl), or —N(C0–6alkyl)(aryl) substituents; R4 is —C1–6alkyl, —C3–7cycloalkyl, heteroaryl, or aryl; optionally substituted with 1–5 independent halogen, —CN, —C1–6alkyl, —O(C0–6alkyl), —O(C3–7cycloalkyl), —O(aryl), —O(heteroaryl), —N(C0–6alkyl)(C0–6alkyl), —N(C0–6alkyl)(C3–7cycloalkyl), or —N(C0–6alkyl)(aryl) substitutents; A is a bond Y is optionally substituted wit 1–7 independent halogen, —CN, NO R5, R6, and R7 each independently is —C0–6alkyl, —C3–7cycloalkyl, heteroaryl, or aryl; any of which is optionally substituted with 1–5 independent halogen, —CN, —C1–6alkyl, —O(CO0–6alkyl), —O(C3–7cycloalkyl), —O(aryl), —O(heteroaryl), —N(C0–6alkyl)(C0–6alkyl), —N(C0–6alkyl)(C3–7cycloalkyl), or —N(C0–6alkyl)(aryl) substituents; R8 is —C1–6alkyl, —C3–7cycloalkyl, heteroaryl, or aryl; optionally substituted with 1–5 independent halogen, —CN, —C1–6alkyl, —O(C0–6alkyl), —O(C3–7cycloalkyl), —O(aryl), —O(heteroaryl), —N(C0–6alkyl)(C0–6alkyl), —N(C0–6alkyl)(C3–7cycloalkyl), or N(C0–6alkyl)(aryl) substituents; B is a bond R9 and R10 each independently is —C0–6alkyl, C3–7cycloalkyl, heteroaryl, or aryl; any of which is optionally substituted with 1–5 independent halogen, —CN, —C1–6alkyl, —O(C0–6alkyl), —O(C3–7cycloalkyl), —O(aryl), —O(heteroaryl), —N(C0–6alkyl)(C0–6alkyl), —N(C0–6alkyl)(C3–7cycloalkyl), —N(C0–6alkyl)(aryl) substituents; R11 is halogen, —C0–6alkyl, —C0–6alkoxyl, ═O, ═N(C0–4alkyl),or —N(C0–4alkyl)(C0–4alkyl); any alkyl optionally substituted with 1–5 independent halogen substitutents, and any N may be an N-oxide; and.