Patent ID: 6017734
Filing Date: 2000-01-25
Classification: C07K,C12N

Abstract:
A nucleic acid segment comprising at least a first sequence region that encodes a targeting polypeptide of between 12 and about 24 amino acids in length, wherein said first sequence region is separated from sequences that naturally flank said sequence region, said polypeptide comprising a twelve amino acid targeting sequence comprising:a) a first amino acid selected from the group consisting of valine, leucine and isoleucine;b) a second amino acid selected from the group consisting of leucine, isoleucine, valine and glycine;c) a third amino acid selected from the group consisting of isoleucine, leucine, alanine and glycine;d) a fourth amino acid selected from the group consisting of isoleucine, alanine, leucine and valine;e) a fifth amino acid selected from the group consisting of valine, leucine and isoleucine;f) a sixth amino acid selected from the group consisting of isoleucine, valine, leucine and phenylalanine;g) a seventh amino acid selected from the group consisting of valine, leucine and isoleucine;h) an eighth amino acid selected from the group consisting of valine, leucine, alanine, glycine, isoleucine and threonine;i) a ninth amino acid selected from the group consisting of isoleucine, leucine, phenylalanine, valine and alanine;j) a tenth amino acid selected from the group consisting of phenylalanine, leucine, valine and isoleucine;k) an eleventh amino acid selected from the group consisting of leucine, valine, phenylalanine, isoleucine and glycine; andl) a twelfth amino acid selected from the group consisting of isoleucine, phenylalanine and tyrosine.