Patent ID: 6281240
Filing Date: 2001-08-28
Classification: A61K

Abstract:
A method of treating secretory diarrhea in a mammal which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound of the formula ##STR27##wherein:R.sup.1 is selected from the group consisting of ##STR28##wherein:E is nitrogen, sulfur, or oxygen;where A is --O--, --S(O).sub.n --, --CH.sub.2 S(O).sub.n --, --NR--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--;D is --CH.sub.2 --, --S(O).sub.n --, --NR--, --CH.sub.2 S(O).sub.n --, or --O--;B is --CH.sub.2 --, --O--, --S(O).sub.n --, or --NR--;R is methyl or ethyl;n is 0-2;provided that at least one of A, B, and D is not --S(O).sub.n -- or --CH.sub.2 S(O).sub.n --; andR.sup.a, R.sup.b, and R.sup.c are independently selected from the group consisting of hydrogen, halo, C.sub.1 -C.sub.3 alkyl C.sub.1 -C.sub.3 alkoxy, and trifluoromethyl;or one of R.sup.a, R.sup.b, and R.sup.c is C.sub.2 -C.sub.8 alkenyl, another of R.sup.a, R.sup.b, and R.sup.c hydrogen or hydroxy, and the other of R.sup.a, R.sup.b, and R.sup.c is hydrogen;R.sup.4 and R.sup.5 are independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, halo, C.sub.1 -C.sub.3 alkyl, or trifluoromethyl; andR.sup.2 is halo, C.sub.1 -C.sub.3 alkyl, or trifluoromethyl;or a pharmaceutically acceptable salt or solvate thereof.