Patent ID: 6797718
Filing Date: 2004-09-28
Classification: A61P,C07D

Abstract:
A compound of the Formula (Ia): wherein:X is â€”CH(R5)â€”, â€”CH(R5)-alkylene-, â€”CH(R5)-alkenylene-, or â€”CH(R5)-alkylene-Y-alkylene-; Y is â€”Oâ€”, or â€”S(O)0-2â€”; â€”Wâ€”R1 is â€”Oâ€”R1-1-5; R1-1-5 is selected from â€”R6â€”C(R7)â€”Zâ€”R8-alkyl; â€”R6â€”C(R7)â€”Zâ€”R8-alkenyl; â€”R6â€”C(R7)â€”Zâ€”R8-aryl; â€”R6â€”C(R7)â€”Zâ€”R8-heteroaryl; â€”R6â€”C(R7)â€”Zâ€”R8-heterocyclyl; â€”R6â€”C(R7)â€”Zâ€”H; â€”R6â€”N(R9)â€”C(R7)â€”R8-alkyl; â€”R6â€”N(R9)â€”C(R7)â€”R8-alkenyl; â€”R6â€”N(R9)â€”C(R7)â€”R8-aryl; â€”R6â€”N(R9)â€”C(R7)â€”R8-heteroaryl; â€”R6â€”N(R9)â€”C(R7)â€”8-heterocyclyl; and â€”R6â€”N(R9)â€”C(R7)â€”R10; Z is â€”N(R5)â€”, â€”Oâ€”, or â€”Sâ€”; wherein heteroaryl is an aromatic ring or ring system that contains at least one ring heteroatom selected from the group consisting of O, S, and N; and heterocyclyl is a non-aromatic ring or ring system that contains at least one ring heteroatom selected from the group consisting of O, S, and N; each R5 is independently hydrogen, C1-10 alkyl, or C2-10 alkenyl; R6 is alkylene, alkenylene, or alkynylene, which may be interrupted by one or more â€”Oâ€” groups; R7 is &boxH;O or &boxH;S; R8 is a bond, alkylene, alkenylene, or alkynylene, which may be interrupted by one or more â€”Oâ€” groups; R9 is hydrogen, C1-10 alkyl, or arylalkyl; or R9 can join together with any carbon atom of R6 to form a ring of the formula R10 is hydrogen or C1-10 alkyl; or R9 and R10 can join together to form a ring selected from R12 is C2-7 alkylene which is straight chain or branched, wherein the branching does not prevent formation of the ring; and RX, RY and RZ are independently selected from hydrogen and non-interfering substitutents; or a pharmaceutically acceptable salt thereof, wherein the compound or salt of Formula Ia induces the biosynthesis of one or more cytokines.