Patent ID: 6017906
Filing Date: 2000-01-25
Classification: A61K,Y02A

Abstract:
A method of enhancing the anti-infective activity of an anti-infective agent comprising administering an effective dose of an anti-infective agent in the presence of a compound of the formula (I) ##STR4## in which; R.sub.1 can be an H, OH, OR.sub.5, NH.sub.2, NHR.sub.6 or NR.sub.6 R.sub.7 ;R.sub.2 and R.sub.3 may be the same or different and can be a H, OH or OR.sub.5 ;R.sub.4 can be CONH.sub.2, CONHR.sub.6, CONR.sub.6 R.sub.7, CH.sub.2 NH.sub.2, CH.sub.2 NHR.sub.6, CH.sub.2 NR.sub.6 R.sub.7, CO.sub.2 --Y--NH.sub.2, CO.sub.2 --Y--NHR.sub.6, or CO.sub.2 --Y--NR.sub.6 R.sub.7 ;R.sub.5 is a protected or unprotected glycosyl moiety comprising 1 -10 monosaccharide units in which the glycosidic linkage at the anomeric carbon atom of each monosaccharide unit is independently alpha or beta;NH.sub.2, NHR.sub.6, and NR.sub.6 R.sub.7 represent an unsubstituted amino group, a monosubstituted amino group, and a disubstituted amino group, respectively, in which R.sub.6 and R.sub.7 may be the same or different and represent a hydrocarbon group comprising 1-15 carbon atoms substituted with one or more unsubstituted, monosubstituted or disubstituted amino groups;Y represents a linear or branched alkylene group comprising 1-10 carbon atoms;n is an integer from 0-10;or its pharmaceutically acceptable salts;provided that if R.sub.1 is OH, R.sub.2 is OH and R.sub.3 is H, or OH; or if R.sub.1 is OH, R.sub.2 is H and R.sub.3 is OH; then R.sub.4 cannot be a CONH.sub.2, CONHCH.sub.2 CH.sub.2 N (C.sub.2 H.sub.5).sub.2, CON (CH.sub.2 CH.sub.2).sub.2 N--CH.sub.3, CH.sub.2 NH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 N (C.sub.2 H.sub.5).sub.2, or CH.sub.2 N (CH.sub.2 CH.sub.2).sub.2 N--CH.sub.3 group.