Patent ID: 7078383
Filing Date: 2006-07-18
Classification: A61K,C07K,C12N,C40B

Abstract:
1. A polypeptide which inhibits human neutrophil elastase, and which comprises a Kunitz domain comprising at least two modifications of the amino acid sequence of the carboxyl-proximal Kunitz domain of the human Inter-α-Trypsin-Inhibitor (ITI-D2) set forth in SEQ ID NO:25 wherein the modifications are amino acid substitutions selected from the group of substitutions consisting of: (a) a substitution of the residue corresponding to position 3 of SEQ ID NO:25 with Glu, (b) a substitution of the residue corresponding to position 15 of SEQ ID NO:25 with Ile, (c) a substitution of the residue corresponding to position 18 of SEQ ID NO:25 with Phe, (d) a substitution of the residue corresponding to position 19 of SEQ ID NO:25 with Pro, and (e) a substitution of the residue corresponding to position 20 of SEQ ID NO:25 with Arg.