Patent ID: 7462742
Filing Date: 2008-12-09
Classification: C07C

Abstract:
1. In situ or one-pot process for the preparation of a compound of general formula (I): in which R R2 and R3 independently are a hydrogen atom, a linear or branched C R4 is a hydrogen atom or a linear or branched C n is the integer 0, 1, 2, 3 or4, the process comprising: a) hydrogenation of a nitrile group of the compound of general formula (II): in which R b) reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb of between 30° C. and 80° C., by, at the end of hydrogenation of step a), raising the temperature of the reaction medium to said temperature Tb to give the dimethylated amine of general formula (I) by activation of the methylating agent.