Patent ID: 6541680
Filing Date: 2003-04-01
Classification: A61K

Abstract:
A method for increasing methylation of DNA in a mouse offspring comprising:a) administering to a pregnant mouse carrying offspring or to a mouse in preparation for pregnancy, a pharmaceutical composition comprising the following components: choline, betaine, folic acid, vitamin B12 and, optionally, at least one component selected from the group consisting of L-methionine and zinc, wherein the dosage amounts of said components within the composition are: about 5-15 g/kg diet/day of choline; about 5-15 g/kg diet/day of betaine; about 5-15 mg/kg diet/day of folic acid; about 0.5-1.5 mg/kg diet/day of vitamin B12; 0 to about 7.5 g/kg diet/day of L-methionine; and 0 to about 150 mg/kg diet/day of zinc; whereby methylation of DNA in said mouse offspring is increased.