Patent ID: 8646246
Filing Date: 2014-02-11
Classification: A61J,A61K,B32B,Y10T

Abstract:
1. A method for manufacturing a composition in blister packages, which comprises: (a) molding a complex aluminum substrate material with blister molding equipment, forming a plurality of depressions in said complex aluminum substrate material, wherein said complex aluminum substrate material comprises an intermediate aluminum layer, and first and second outer layers, wherein the first and second outer layers are composed of materials selected from polyethylene, polypropylene, polyvinyl chloride, polyvinylidene chloride, polyamide, cyclo olefin copolymer, polyurethane or their mixture, wherein material of the first outer layer differs from that of the second outer layer, and flexural rigidity of the first outer layer differs from that of the second outer layer by 0-30%; (b) filling a liquid composition into the plurality of depressions formed in step (a); (c) freezing said composition; (d) freeze-drying said composition; (e) attaching a lidding material to said package material to seal said composition, wherein, the first outer layer comprises an OPA layer and a layer of COC and PE mixture, and the material of the second outer layer is selected from polyethylene, polypropylene, polyvinyl chloride, polyvinylidene chloride, polyamide, cyclo olefin copolymer, polyurethane or their mixture.