Patent ID: 6184359
Filing Date: 2001-02-06
Classification: A61K,Y10S

Abstract:
A humanized antibody which specifically binds epithelium-derived T-cell factor polypeptide, wherein said polypeptide is selected from the group consisting of:(a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 3;(b) a polypeptide comprising the amino acid sequence of SEQ ID NO: 6; and(c) a polypeptide encoded by an isolated nucleic acid selected from the group consisting of:(i) DNA comprising nucleotides 145 through 486 of the DNA sequence of SEQ ID NO: 1 or 4;(ii) DNA that detectably hybridizes to the DNA of (i) or their complementary strands under conditions of high stringency and upon expression encodes epithelium-derived T-cell factor; and(iii) DNA that, due to the degeneracy of the genetic code, encodes a polypeptide, encoded by any of the foregoing DNA sequences.