Patent ID: 7442385
Filing Date: 2008-10-28
Classification: A61J,A61K,A61P

Abstract:
1. A composition comprising particles having a matrix of water-swellable water-insoluble polymer and, absorbed in the matrix, a water-soluble therapeutic agent, and is characterised in that the polymer has an overall anionic charge at a pH in the range 6 to 8, in that the particles, when swollen to equilibrium in water have particle sizes in the range 40-1500 μm and in that the therapeutic agent is an anthracycline compound having at least one amine group, wherein the level of anion in the polymer matrix is in the range 0.1 to 10 meq/g, wherein the polymer is covalently cross-linked and comprises cross-linked poly(vinyl alcohol); and wherein the particles are microspheres.