Patent ID: 8741887
Filing Date: 2014-06-03
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) selected from the group consisting of: a compound wherein Y is thiazol-2-yl, Z is 4-phenylmethyl-phenyl, s is 1, and R a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-(pyridin-4-ylmethoxy)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-4-(3,4-dichlorophenylmethoxy)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-(3-chlorophenylmethoxy)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-4-(2,3-dichlorophenylmethoxy)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-(pyridin-2-ylmethoxy)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylmethylthio)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3,4-dichlorophenylmethylthio)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-chlorophenylmethylthio)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(pyridin-3-ylmethylthio)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenoxymethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylthiomethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylaminomethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-chlorophenoxymethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-chlorophenylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(5-chloro-thien-2-ylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(quinolin-2-ylmethoxy)-phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(quinolin-2-ylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenylmethylthio)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(5-chloro-pyridin-3-ylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethyl-phenyl-fluoromethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(6-bromo-pyridin-2-ylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethylphenylmethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(phenyl-difluoromethyl)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-phenylmethyl-2,3-dihydro-1H-indol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenylmethyl)phenyl, and s is 0; a compound wherein Y is 4-(4-trifluoromethylphenylmethyl)phenyl, Z is thiazol-4-yl, and s is 0; a compound wherein Y is 4-(4-trifluoromethylphenylmethyl)phenyl, Z is thiazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenylmethyl)phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 4-(4-trifluoromethyl-phenylmethyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4-trifluoromethylphenyl-methyl)-4-fluoro-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-methyl-3-(4-trifluoromethylphenyl-methyl)phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-[2-(4-chloro-phenyl)-1-methyl-vinyl]-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 5-[2-(4-chloro-phenyl)-1-methyl-vinyl]-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 5-[2-(4-chloro-phenyl)-1-methyl-vinyl]-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 7-(4-chloro-benzylidene)-1-(2,4-dichloro-phenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(2,4-dichloro-phenyl)-7-(4-fluoro-benzylidene)-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazol-3-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 3-(4-fluorophenylcarbonyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(4-fluorophenylmethyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 1-methyl-3-(4-fluorophenylmethyl)-indol-6-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 1-methyl-3-(4-fluorophenylmethyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluoro-phenylmethyl)-1H-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-fluorophenylmethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(3-fluorophenylmethyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-(phenylmethyl)-indol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethyl-phenylmethyl)-1H-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenylmethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethyl-phenylmethyl)-1H-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylphenylmethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is (1-phenyl-ethyl)-2H-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethyl-phenylaminocarbonylmethoxy)-phenyl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluoro-phenylmethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-cyano-phenylmethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluoro-phenylethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-fluoro-phenylethyl)-indazol-5-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 2-(4-fluoro-phenylmethyl)-indazol-6-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 1-(4-chloro-phenylmethyl)-3-methyl-1H-thieno[2,3-c]pyrazol-5-yl, and s is 0; or a pharmaceutically acceptable salt form thereof.