Patent ID: 8318712
Filing Date: 2012-11-27
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising: from 0.1 mg/ml to 0.2 mg/ml levothyroxine or a pharmaceutically acceptable salt thereof, from about 10% to about 50% (by weight) hydroxypropyl-β-cyclodextrin, at least one buffer having a pKa of at least about 9.5, at least 5% (by weight) water, a preservative at a concentration of no greater than about 30% (by weight), from about 5% to about 20% (by weight) ethanol, and a pharmaceutically acceptable antioxidant at a concentration of no greater than about 5% (by weight); wherein the pharmaceutical composition is liquid and has a pH of from about 10 to about 10.5.