Patent ID: 7985337
Filing Date: 2011-07-26
Classification: A61M

Abstract:
1. A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers ( 4 ) based on organic polymers, whereby the hollow fibers ( 4 ) have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement ( 1 ) and an outlet arrangement ( 3 ) and whereby an outer space is formed between the hollow fibers ( 4 ) and the housing, which space is accessible for a fluid via the inlet arrangement ( 1 ) and the outlet arrangement ( 3 ), characterized in that only the external surfaces of the hollow fibers ( 4 ) are accessible for a fluid, that the lumen of the hollow fibers ( 4 ) are not accessible for a fluid, that the arrangement of the hollow fibers ( 4 ) shows a high degree of order and that the hollow fibers ( 4 ) based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m 2 of fiber surface.