Patent ID: 6197341
Filing Date: 2001-03-06
Classification: A61K,A61P,Y10S

Abstract:
A unit formulation which comprises a compound of formula ##STR2##whereinX represents SO.sub.2 or CO;R.sup.1 represents phenyl, carboxymethylphenyl or --R.sup.2 Y;R.sup.2 represents (CH.sub.2).sub.n or benzyl-(CH.sub.2).sub.n wherein one or more of the hydrogen atoms of the alkylene moiety may be replaced by a C.sub.1-6 -alkyl, NH.sub.2, NH(C.sub.1-6 -alkyl) or N(C.sub.1-6 -alkyl).sub.2 group;Y represents COOH, SO.sub.3 H, OH, NH.sub.2, NHR.sup.3 or N(R.sup.3).sub.2 ;R.sup.3 represents C.sub.1-6 -alkyl optionally substituted by a carboxylic or sulphonic acid group; andn is an integer from 1 to 6;or an ester thereof; or an active metabolite thereof; or a non-toxic pharmaceutically acceptable salt thereof;in association with one or more pharmaceutically acceptable excipients or binding agents;which formulation is in the form of a tablet having a density of at least 0.9 mg/mm.sup.3.