Patent ID: 8304396
Filing Date: 2012-11-06
Classification: A61K,A61P,C07H,C12N

Abstract:
1. A method for treating a vertebrate having renal cell carcinoma, lung cancer, or neuroblastoma, the method comprising administering a modified oligonucleotide having at least two CpG immunostimulatory motifs, wherein C is unmethylated cytidine, and G is guanosine, wherein each CpG has a phosphodiester or phosphodiester-like internucleotide linkage, and wherein all other internucleotide linkages are stabilized, to a mucosal surface of the vertebrate, wherein the stabilized internucleotide linkage is a phosphorothioate linkage, and wherein the administration results in the treatment of the vertebrate having renal cell carcinoma, lung cancer, or neuroblastoma.