Patent ID: 6800656
Filing Date: 2004-10-05
Classification: A61P,C07C,C07D

Abstract:
The present invention provides a compound of the formula and its pharmaceutically acceptable salts, or the compound and its pharmaceutical composition having useful antiviral activity against viruses of the herpes family. Wherein:X=a chemical bond; Y=O, S; Z=N, NH, O, NHR8, NR8, S, SO, SO2; n=an integer of from 1 to 2; R1, R2, R3, and R5 independently are hydrogen, halogen, hydroxyl, amino, mono or dialkylamino, cyano, nitro, alkyl groups (1-6 carbon atoms), alkoxy groups (1-6 carbon atoms), CF3, OCF3, aminoalkyl (1-6 carbon atoms), aminoaryl, Oaryl, or a heterocyclic ring having 5-7 atoms with 1-4 hetero atoms of N, O or S and R4 is hydroxyl, alkoxy groups (1-6 carbon atoms) CF3, OCF3, Oaryl or a heterocyclic ring having 5-7 atoms with 1-4 hetero atoms of N, O or S; Ar=phenyl, substituted phenyl, benzoheterocyclic ring, substituted benzoheterocyclic ring, heterocyclic ring or substituted-heterocyclic ring, which have substitutions R6 or R7 R6 and R7 are independently hydrogen, alkyl group (1-6 carbon atoms), cycloalkyl (3-12 carbon atoms), halogen, alkoxy, CF3, aminoalkyl (1-6 carbon atoms), aminoaryl, or a heterocyclic ring of from 5-7 atoms with 1-4 heteroatoms of N, O or S; R6 and R7 may also form a ring, optionally cycloalkyl or aryl or substituted aryl; R8 is hydrogen, alkyl (1-6 carbon atoms), cycloalkyl (3-8 carbon atoms), phenyl or substituted phenyl wherein the substituents are selected from alkyl group (1-6 carbon atoms), cycloalkyl (3-12 carbon atoms), halogen, alkoxy, CF3, aminoalkyl (1-6 carbon atoms), aminoaryl, or a heterocyclic ring of from 5-7 atoms with 1-4 heteroatoms of N, O or S.