Patent ID: 6828444
Filing Date: 2004-12-07
Classification: C07D,C07F

Abstract:
A method of selectively reducing enone of formula XIV: to allylic alcohol of formula XV: wherein:R4, R5, R6=same or different=alkyl, cycloalkyl, or aryl; X=(CH2)q or (CH2)qO; q=1-6; and Y=a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, or a free or functionally modified hydroxy or amino group; or X-Y=(CH2)mY1, m=0-6, â€ƒwherein: W=CH2, O, S(O)m, NR10, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)m, CH&boxH;N, or CH2NR10; m=0-2; R10=H, alkyl, acyl; Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino. alkylamino, acylamino, OH; and =is a single or double bond; comprising, contacting said enone with a reducing agent selected from the group consisting of: (âˆ’)-B-chlorodiisopinocampheylborane and (+)-B-chlorodiisopinocampheylborane, in an amount sufficient to effect such reduction.