Patent ID: 7026451
Filing Date: 2006-04-11
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated polypeptide monomer of an SK2 calcium-activated potassium channel, said monomer forming a potassium channel having a unit conductance of between 2 and 60 pS when a nucleic acid encoding the monomer is expressed in a Xenopus oocyte, wherein said polypeptide is encoded by a nucleic acid that selectively hybridizes under stringent conditions to a sequence of SEQ ID NO:21, wherein the hybridization reaction is incubated overnight at 37° C. in a solution comprising 40% formamide, 1 M NaCl and 1% SDS, and washed at 55° C. in a solution comprising 0.5×SSC.