Patent ID: 7858073
Filing Date: 2010-12-28
Classification: A61K,A61P,G01N

Abstract:
1. A method for selecting at least one microbial isolate for use in an oral killed vaccine against abnormal microbial colonization of a mucosal surface, of the selected microbial isolate or isolates, the method comprising: evaluating capacity of a plurality of different isolates of a unicellular microbe to activate antigen responsive cells to provide activation data for each microbial isolate; evaluating effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate; and selecting at least one isolate from the microbial isolates, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, for use in formulating the vaccine.