Patent ID: 6313132
Filing Date: 2001-11-06
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of Formula (I): ##STR17##wherein:R.sup.1 is hydrogen, hydroxy, alkyl, alkoxy, hydroxyalkyl, trifluoromethyl, amino, alkylcarbonylamino, alkylcarbonyloxy, halogen,R.sup.2 and R.sup.3 independently are hydrogen, hydroxy, alkyl, alkoxy, hydroxyalkyl, halogen, alkoxycarbonylalkyl, carbamoyl, sulphamoyl,R.sup.4 is .omega.-hydroxyalkoxy, .omega.-aminoalkoxy, .omega.-aminoalkylamino, alkoxyalkyl, hydroxyalkoxyalkylaminoalkyl, alkoxycarbonylalkyl, dihydroxyalkyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylaminoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, carbamoylalkyl, carboxamidoalkyl, carboxyl, amino, nitro, cyano, nitrilo, cyanoalkyl, azido, alkyl having two or more carbon atoms, alkoxy having two or more carbon atoms, hydroxyalkyl having two or more carbon atoms,R.sup.5 is hydrogen, halogen, alkyl,Ar is aryl or heteroaryl wherein said aryl or heteroaryl are unsubstituted or independently substituted with one or two alkyl, alkoxy, hydroxy, hydroxyalkyl, halogen, alkoxycarbonylalkyl, carbamoyl, or sulphamoyl, andR.sup.6 and R.sup.7 are hydrocarbyl groups which are the same or different, together having three or more carbon atoms, and unsubstituted or substituted by one or more hydroxy groups, and wherein carbon atoms are or are not interconnected by oxygen atoms, and wherein R.sup.6 and R.sup.7 may or may not together form a ring with the amine nitrogen;with the provisions that (a) when:(i) two or more of R.sup.2, R.sup.3, and R.sup.5 are other than hydrogen, or(ii) R.sup.1 is other than hydroxy or methoxy, and Ar is other than phenyl that is ortho-substituted by hydroxy or methoxy, or(iii) Ar is heteroaryl, or(iv) one or more of R.sup.6 and R.sup.7 is aromatic hydrocarbyl or cycloalkyl, thenR.sup.4 must be hydrogen, methyl, methoxy, hydroxymethyl, hydroxy, halogen, carbamoyl, or sulphamoyl;and (b), when Ar is unsubstituted phenyl, then R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 can not all be hydrogen; andphysiologically acceptable salts thereof, or the racemic mixture or the enantiomers thereof.