Patent ID: 6066726
Filing Date: 2000-05-23
Classification: A61K,C07K,C12N

Abstract:
An isolated DNA molecule comprising:a) a neuron-specific transcriptional promoter, which is more transcriptionally active in hippocampal cells than in neocortical cells, the promoter comprising a transcriptional initiation sequence element 5'-GCGCAGGTCCATTCGGGAAT-3' SEQ ID NO: 18, and sequence elements 5'-ACTAGGAATATTGTTTG-3' SEQ ID NO: 17 and 5'-GGACATGGAGCAC-3' SEQ ID NO: 19 positioned at least 35 nucleotide base pairs upstream from the transcription initiation sequence element; andb) a collection of one or more cis-acting elements, wherein said elements are CAAT boxes that confer orientation specificity on the transcriptional activity of the promoter, and are functionally located upstream from the promoter.