Patent ID: 6792355
Filing Date: 2004-09-14
Classification: G01N,G16B

Abstract:
A method for separating two or more subsets of polypeptides within a set of polypeptides, comprising:(a) determining a sequence comparison signature for each amino acid sequence in a set of amino acid sequences, wherein said sequence comparison signature comprises pairwise comparison scores for said amino acid sequence compared to each of the other amino acid sequences in said set; (b) constructing a distance arrangement comprising said sequence comparison signatures related according to the distance between each of said sequence comparison signatures; and (c) identifying a first and second cluster of sequence comparison signatures in the distance arrangement, wherein said first cluster comprises sequence comparison signatures for polypeptides having a similar protein fold or biological function, said protein fold or function being different compared to a protein fold or function of polypeptides having sequence comparison signatures in said second cluster, wherein said pairwise comparison score is determined by an algorithm selected from the group consisting of Smith-Waterman, BLAST, FASTA, Needleman-Wunach, Seller and PSI-BLAST.