Patent ID: 8124084
Filing Date: 2012-02-28
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A method for increasing proliferation of immune cells, comprising administering to a human an effective amount of a composition, wherein the composition comprises: a. a purified interleukin-15 (IL-15) polypeptide and a purified soluble form of an interleukin-15 receptor alpha (IL-15Ra) polypeptide; b. a purified chimeric polypeptide in which an IL-15 polypeptide is linked to a soluble form of an IL-15Ra polypeptide; c. a purified IL-15 polypeptide and a purified chimeric polypeptide in which a soluble form of an IL-15Ra polypeptide is covalently linked to the Fc portion of an antibody; d. a purified complex comprising an IL-15 polypeptide bound to a soluble form of an IL-15Ra polypeptide; or e. a purified complex comprising an IL-15 polypeptide bound to a soluble form of an IL-15Ra polypeptide that is covalently linked to the Fc portion of an antibody, wherein said administration results in increasing proliferation of immune cells.