Patent ID: 6638921
Filing Date: 2003-10-28
Classification: A61P,C07F

Abstract:
A compound of formula I wherein Cx is selected from the group consisting of â€”CH&boxH;O, â€”CH&boxH;Nâ€”OH and â€”CH(OCH2CH3)2,wherein R1 is selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, F, Cl, Br, I, â€”CN and â€”COOH, wherein R2 is selected from the group consisting of â€”COOH, â€”SO2NR3R4, â€”SO2R5, â€”CONR3R4 and â€”COR5, wherein R3 is selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, and a branched alkyl group of 3 to 6 carbon atoms, wherein R4 is selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 8 carbon atoms, adamantan-1-yl, â€”CH2CH2OH, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 1,2,3,4-tetrahydroquinolin-5-yl, isoquinolin-5-yl, isoazol-3-yl, 2-halogeno-phenyl, 3-halogeno-phenyl, 4-halogeno-phenyl (halogeno being F, Cl, Br or I), 1,4,5,6-tetrahydropyrimidin-2-yl, pyrimidin-2-yl, 2,6-dimethylpyrimidin-4-yl, thiazol-2-yl and a group of formula wherein R5 is selected from group consisting of aziridin-1-yl, azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, azocanyl (i.e., the azacycloalkanes, 3 to 8 member ring system) and morpholin-4-yl, wherein m is 0, 1, 2 or 3, wherein n is 0 or 1, provided that when Cx is â€”CH&boxH;O and R1 is H or m is 0, n cannot be 0, provided that when Cx is â€”CH&boxH;O, R1 is Cl, m is 1 and n is 0, R1 is in a position selected from the group consisting of the 3â€², 4â€² and 5â€² position, provided that when Cx is â€”CH&boxH;O and R1 is â€”COOH, m is 1 and n is 0, R1 is in a position selected from the group consisting of the 2â€² and 6â€² position, provided that when Cx is â€”CH&boxH;O, R1 is Cl, m is 1, n is 1, and R2 is â€”COOH; R1 may not occupy the 3â€² position when R2 occupies a position selected from the group consisting of 2â€² and 4â€² position, and; R1 may not occupy the 2â€² position when R2 occupies a 5â€² position.