Patent ID: 8425920
Filing Date: 2013-04-23
Classification: A61K,A61P,G01N

Abstract:
1. A method for modulating intestinal homeostasis by generating adaptive lymphoid tissue comprising: administering to a subject in need thereof who is a neonate, a subject with a naïve immune system, or a subject who has a reduced number of ILFs prior to treatment due to an innate immune defect compared to a normal subject, an agent that is an NOD1 (nucleotide oligomerization domain 1) ligand that is an isolated or purified gram-negative peptidoglycan removed from other components of a gram-negative bacterium or an isolated or purified muropeptide obtained from said gram-negative peptidoglycan in an amount sufficient to induce or enhance the formation of ILFs (isolated lymphoid follicles) in said subject compared to a control subject not receiving said NOD1 (nucleotide oligomerization domain 1) ligand.