Patent ID: 8372379
Filing Date: 2013-02-12
Classification: A61K,C07D

Abstract:
1. Tridentate chelators of the type tris(pyrazolyl)methane (R 1 C(pf*) 3 ) and bis(pyrazolyl)amine((pz*) 2 CH(CH 2 ) n NHR 1 or (pz*)(CH 2 ) n NR 1 (CH 2 ) n (pz*) of formulae (I), (II) and (III) respectively: wherein at least one of R 1 R 2 , R 3 and R 4 is a linear or macrocyclic ether group of the type —R x —O—R Y or [(CH 2 ) x O] y (CH 2 ) z (x=2-3, y=3-8, z=2-5), respectively, and each of the other three R groups is independently hydrogen; a linear or branched, saturated or unsaturated C 1 to C 9 alkyl; a saturated or unsaturated carbocyclic group; a saturated or unsaturated heterocyclic or heteroaliphatic group with one or more atoms selected from O, N and S, wherein said carbocyclics, heterocyclics and heteroaliphatics are optionally substituted by one or more linear or branched, saturated or unsaturated C 1 to C 9 alkyls; an ether group —R x —O—R Y or [(CH 2 ) x O] y (CH 2 ) z (x=2-3, y=3-8, z=2-5), wherein R x and R Y are independently linear or branched, saturated or unsaturated C 1 to C 9 alkyl, or saturated or unsaturated carbocyclics, any of which alkyl and/or carbocyclic groups may be substituted or unsubstituted, provided that when the tridentate chelator is of the type of formula (I), when R and when R