Patent ID: 6770651
Filing Date: 2004-08-03
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 is optionally substituted alkyl or a group â€”Yâ€”Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; R2 is hydrogen, acyl, optionally substituted alkyl, or a group â€”Yâ€”Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; R3 is hydrogen, optionally substituted alkyl or a group â€”Yâ€”Z1, in which Y is a covalent bond or optionally substituted alkylene, and Z1 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaxyl, optionally substituted heterocyclyl, optionally substituted amino, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be amino, alkenyl or alkynyl; R4 and R6 are independently hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; R5 is hydrogen, optionally substituted alkyl, halo, CF3, nitro, cyano, optionally substituted alkoxy, optionally substituted thioalkoxy, optionally substituted amino, optionally substituted sulfoxide, optionally substituted sulfone, optionally substituted sulfonamide, optionally substituted acylamino, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; and X is oxygen, sulfur, or NH, or a pharmaceutically acceptable salt, ester, or prodrug thereof.