Patent ID: 8071753
Filing Date: 2011-12-06
Classification: A01K,A61K,A61P,C12N

Abstract:
1. A nucleic acid sequence producing at least one functional micro RNA (miRNA), at least one functional short-hairpin RNA (shRNA), and/or at least one functional small interfering RNA (siRNA); said miRNA, shRNA, and/or siRNA being designed to silence the expression of a gene that encodes a cholinergic protein, choline acetyltransferase (ChAT); wherein the sense sequence of said nucleic acid sequence is 5′-GAGCGAGCCUUGUUGACAUUU-3′ (SEQ ID NO: 13) and the antisense sequence of said nucleic acid sequence is 5′-AUGUCAACAAGGCUCGCUCUU-3′ (SEQ ID NO: 14).