Patent ID: 6777405
Filing Date: 2004-08-17
Classification: C07F

Abstract:
A composition for treating a condition wherein the condition includes error or damage in a duplex polynucleotide, comprising:an effective amount of a composition e comprising an active hindered intercalating compound, wherein the compound comprises a compound of the formula: Rh(R1)(R2)(R3)3+wherein R1 and R2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings and R3 is a group of the formula where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R4, R5, and R6 are each independently Hâ€”, halo, HOâ€”, H2Nâ€”, CNâ€”, O2Nâ€”, HSâ€”, O3Sâ€”, O3SOâ€”, â€”COOH, â€”CONH2, R, ROâ€”, RNHâ€”, Ra, RbNâ€”, RO3Sâ€”, RO3SOâ€”, â€”COOR, â€”CONHR, or â€”CONRaRb, where R, R2 and Rb are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R4, R5, or R6 together form a fused aryl ring anda pharmaceutically acceptable excipient.