Patent ID: 6395730
Filing Date: 2002-05-28
Classification: A61K,A61P,C07D

Abstract:
A compound having the following formula or a pharmaceutically acceptable salt, ester, amide, or stereoisomer thereof: wherein,v is 1 t is 0, 1, or 2; X, in an orientation R1â€”Xâ€”, is selected from â€”(CR42)pâ€”; â€”(CR42)(CH2)â€”; â€”(CR42)mO(CR42)nâ€”; â€”(CR42)mCH&boxH;CH(CR42)sâ€”; â€”(CR42)mCH â‰¡CH(CR42)sâ€”; â€”(CR42)mâ€”Aâ€”(CR42)mâ€”; â€”(CR42)mâ€”NR4â€”(CR42)nâ€”; â€ƒwhere p is an integer of 3 to 5, n is an integer of 2 to 4, m is an integer of 0 to 4 and s is an integer of 1 to 4; A is selected from an optionally substituted 3 to 7 membered carbocyclic ring and an optionally substituted 5 to 7 membered heterocyclic ring; each R4 is independently selected from H, a lower alkyl, an aryl and a heteroaryl; W is selected from O and NR5; R5 is selected from H, lower alkyl, aryl, Câ‰¡N and NHR4; R1 is selected from an optionally substituted aryl and an optionally substituted heteroaryl; R2 is selected from an optionally substituted aryl and an optionally substituted heteroaryl, with the provisos that (1) when X is â€”(CR42)(CH2)â€” and R4 is H then R1 cannot be a monoalkylamino or dialkylamino substituted alkoxy substituted phenyl; (2) when X is â€”(CR42)pâ€”, R4 is H and p is 3 to 4 then R1 cannot be a monoalkylamino or dialkylamino substituted alkoxy substituted phenyl; (3) when X is â€”(CR42)(CH2)â€” and R4 is H then R1 cannot be p-nitrophenyl, p-aminophenyl, or (3methoxy-4-ethoxyphenyl) and (4) when X is â€”(CR42)(CH2)â€”, then R2 cannot be pyridyl or indolyl.