Patent ID: 6110955
Filing Date: 2000-08-29
Classification: C07C

Abstract:
A compound represented by the formula: ##STR18## wherein R is a C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl or C.sub.2 to C.sub.10 alkynyl group, optionally substituted with an alkoxy, halo, trifluoromethyl, amino, acylamino, carboxyl, carboxamide, carbalkoxy, hydroxy, acyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl group;R.sup.1 and R.sup.2 are each independently H, C.sub.1 to C.sub.6 straight or branched chain alkyl, C.sub.2 to C.sub.6 branched or straight chain alkenyl or C.sub.2 to C.sub.6 branched or straight chain alkynyl wherein the alkyl, alkenyl or alkynyl group is optionally substituted with halo or alkoxy; andR.sup.3 CO is an acyl moiety of a carboxylic acid-containing compound that inhibits beta-oxidation of fatty acids;with the proviso that when said acyl moiety is the acyl moiety of a NSAID compound, the NSAID is selected from the group consisting of ketoprofen, diflunisal, salsalate, etodolac, tolmetin, ibuprofen, naproxen, oxaprozin, salicylic acid, acetylsalicylic acid, indomethacin, flurbiprofen, diclofenac, mefenamic acid, meclofenamic acid, ketorolac and sulindac; and wherein when the acyl moiety is that of ibuprofen, R is not methyl or ethyl; when the acyl moiety is that of oxaprozin, R is not methyl; when the acyl moiety is that of sulindac or naproxen, R is not alkyl; when the acyl moiety is that of salicylic acid or acetylsalicylic acid, R is C.sub.3 to C.sub.10 alkenyl or lower haloalkyl; and when the acyl moiety is that of indomethacin, flurbiprofen, mefenamic acid, meclofenamic acid or diclofenac, R is C.sub.3 to C.sub.10 haloalkyl, aralkyl, heteroaralkyl, 2-, 3- or 4-arylpropyl or 2-, 3- or 4heteroarylpropyl;or a pharmaceutically acceptable salt thereof.