Patent ID: 6495589
Filing Date: 2002-12-17
Classification: A61K,A61P,C07K

Abstract:
A compound according to the formulaAâ€”Gâ€”Zâ€”W or a pharmaceutically acceptable salt, solvates or hydrate thereof, whereinA is (C6-C10)aryl, (C6-C10)aryl-SO2, (C6-C10)aryl-CH2â€”, (C6-C10)arylcarbonyl, (C1-C9)heteroaryl, (C1-C9)heteroaryl-SO2â€”, (C1-C9)heteroaryl-CH2â€”; or (C1-C9)heteroarylcarbonyl; G is: â€ƒwhere B is (C6-C10)aryl, and X is CH2, SO2, or carbonyl; Z is â€ƒwherein R2 is H, (C1-C8)alkyl, or is selected from groups A above; and E is indolyl; and W is (a): â€ƒwherein n is 2-5, R3 is selected from H, (C1-C8)alkyl-, and phenyl(CH2)â€”; R6 is selected from H, (C1-C8)alkyl-, and phenyl(CH2)â€”; R4 is selected from H, (C1-C8)alkyl-, and phenyl(CH2)â€”, or is â€ƒwhere groups R10, R11 and R11â€² are each, independently, selected from H, (C1-C8)alkyl-, and phenyl(CH2)â€”; R5 is selected from H, (C1-C8)alkyl-, and phenyl (CH2)â€”, or is â€ƒwherein R12 and R12â€² are each independently selected from H, (C1-C8)alkyl-, and phenyl(CH2)â€”, and wherein said (C6-C10)aryl and (C1-C9)heteroaryl groups of A, (C6-C10)aryl groups of B, indolyl group E, and (C6-C10)aryl or (C1-C9)heteroaryl groups of R2 are each substituted, optionally and independently, by one or more functional groups selected from hydroxy, halo, amino, trifluoromethyl, carboxy, (C1-C6)alkoxy-, (C1-C6)acyloxy-, (C1-C6)alkylamino-, ((C1-C6)alkyl)2amino-, (C1-C6)acylamino-, cyano, nitro, (C1-C6)alkyl-, (C2-C6)alkenyl-, (C2-C6)alkynyl-, (C1-C6)acylamino-, cyano(C1-C6)alkyl-, trifluoromethyl(C1-C6)alkyl-, nitro(C1-C6)alkyl-, (C1-C3)alkyl(difluoromethylene)(C1-C3)alkyl-, (C1-C6)acylamino(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)acylamino-, amino(C1-C6)acyl-, amino(C1-C6)acyl(C1-C6)alkyl-, (C1-C6)alkylamino(C1-C6)acyl-, ((C1-C6)alkyl)2amino(C1-C6)acyl-, (C3-C10)cycloalkyl(C1-C6)alkyl-, (C1-C6)acyloxy(C1-C6)alkyl-, (C2-C6)alkoxy(C1-C6)alkyl-, piperazinyl(C1-C6)alkyl-, (C1-C6)acylamino(C1-C6)alkyl-, (C6-C10)aryl(C1-C6)alkoxy(C1-C6)alkyl-, (C2-C9)heteroaryl(C1-C6)alkoxy(C1-C6)alkyl-, (C1-C6)alkylthio(C1-C6)alkyl-, (C6-C10)arylthio(C1-C6)alkyl-, (C1-C6)alkylsulfinyl(C1-C6)alkyl-, (C6-C10)arylsulfinly(C1-C6)alkyl-, (C1-C6)alkysulfonyl(C1-C6)alkyl-, (C6-C10)arylsulfonyl(C1-C6)alkyl-, amino(C1-C6)alkyl-, (C1-C6)alkylamino(C1-C6)alkyl-, (C1-C6)alkyl(difluoromethylene)-, (C1-C3)alkyl(difluoromethylene)(C1-C3)alkyl-, (C1-C6)alkoxy(C1-C6)acyl-, (C1-C6)alkylamino(C1-C6)acyl-, ((C1-C6)alkyl)2amino(C1-C6)acyl-, (C6-C10)aryl-, (C5-C9)heteroaryl-, (C6-C10)aryl(C1-C6)alkyl-, (C2-C9)heteroaryl(C1-C6)alkyl-, (C6-C10)aryl(C6-C10)aryl-, (C6-C10)aryl(C6-C10)aryl(C1-C6)alkyl- (C3-C10)cycloalkyl-, (C3-C6)cycloalkyl(C1-C6)alkyl-, (C3-C10)heterocycloalkyl-, (C3-C10)heterocycloalkyl(C1-C6)alkyl-, hydroxy(C2-C6)alkyl-, (C1-C6)acyloxy(C2-C6)alkyl-, (C1-C6)alkoxy(C2-C6)alkyl-, piperazinyl(C1-C6)alkyl-, (C1-C6)acylamino(C1-C6)alkyl-, (C6-C10)aryl(C1-C6)alkoxy(C1-C6)alkyl-, (C2-C9)heteroaryl(C1-C6)alkoxy(C1-C6)alkyl-, (C1-C6)alkylthio(C1-C6)alkyl-, (C6-C10)arylthio(C1-C6)alkyl-, (C1-C6)alkysulfinyl(C1-C6)alkyl-, (C6-C10)arylsulfinyl(C1-C6)alkyl-, (C1-C6)alkylsulfonyl(C1-C6)alkyl-, (C6-C10)arysulfonyl(C1-C6)alkyl-, amino(C1-C6)alkyl-, (C1-C6)alkylamino(C1-C6)alkyl-, and ((C1-C6)alkyl)2amino(C1-C6)alkyl.