Patent ID: 7033828
Filing Date: 2006-04-25
Classification: A61K,C07K,Y10S

Abstract:
1. A nucleic acid encoding a chimeric receptor having an N-terminus domain, a DNA-binding domain, and a ligand-binding domain, wherein the N-terminus domain of said chimeric receptor is obtained from the N-terminus domain of retinoic acid receptor-alpha (RARα), retinoic acid receptor-beta (RARβ), retinoic acid receptor-gamma (RARγ), glucocorticoid receptor (GR), mineralocorticoid receptor (MR), progesterone receptor (PR), estrogen receptor (ER), vitamin D wherein the DNA-binding domain of said chimeric receptor is obtained from the DNA-binding domain of RARα, RARβ, RARγ, GR, MR, PR, ER, VDR, TR, the v-erb-A receptor, or the wherein the ligand-binding domain of said chimeric receptor is obtained from the ligand-binding domain of RARα, RARβ, RARγ, GR, MR, PR, ER, ERR1, ERR2, VDR, TR, the v-erb-A receptor, or the wherein at least one of the domains of said chimeric receptor comprises a contiguous portion unique to RARγ selected from the group consisting of a nucleotide sequence encoding amino acid residues 1–89 of hRARγ set forth in wherein said chimeric receptor has at least 5% of the DNA-binding, the transcription-activating activity, and/or the ligand-binding activity of RAR