Patent ID: 6828341
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound of Formula VII or pharmaceutically acceptable salts thereof, wherein* means cis or trans or mixtures thereof; R1 is independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, alkylaminoalkyl, hydroxyalkyl, (aminocarbonyl)-alkyl, (alkylthio)-alkyl, carboxyalkyl, haloalkyl, and halogen; g is an integer of from 0 to 3; R is hydrogen or alkyl; d is 0; B is a heterocyclene selected from the group consisting of: X is O, S, or Nâ€”R3 wherein R3 is hydrogen or alkyl; V is CH2; and â€”Eâ€”Yâ€” is selected from the group consisting of â€”CH&boxH;CHâ€”N(H)â€”, â€”(CH2)2â€”N(H)â€”, â€”CH&boxH;Nâ€”N(H)â€”, â€”C(O)â€”CH2â€”N(H)â€”, â€”CH2â€”C(O)â€”N(H)â€”, â€”CH2S(O)â€”N(H)â€”, â€”CH2â€”S(O)2â€”N(H)â€”, â€”CH&boxH;CHâ€”CH(OH)â€”, (CH2)2â€”CH(OH)â€”, â€”C(O)â€”C(H)&boxH;C(OH)â€”, â€”C(O)â€”N&boxH;C(OH)â€”, â€”N&boxH;CHâ€”N(H)â€”, â€”N(H)â€”C(O)â€”N(H)â€”, â€”Oâ€”C(O)â€”NHâ€”, â€”Sâ€”C(O)â€”NHâ€”, â€”Oâ€”N&boxH;CH(OH)â€”, â€”Sâ€”N&boxH;CH(OH)â€”, â€”N&boxH;Nâ€”N(H)â€”, â€”N&boxH;Nâ€”N(OH)â€”, â€”CH&boxH;CHâ€”CH&boxH;C(OH)â€”, â€”(CH2)3â€”CH(OH)â€”, â€”(CH2)2â€”C(O)â€”N(H)â€”, â€”(CH2)2â€”S(O)â€”N(H)â€”, â€”(CH2)2â€”S(O)2â€”N(H)â€”, â€”CH&boxH;CHâ€”C(O)â€”N(H)â€”, â€”C(O)â€”NHâ€”N&boxH;C(OH)â€”, â€”CH&boxH;Nâ€”N&boxH;C(OH)â€”, â€”CH&boxH;N(O)â€”N&boxH;C(OH)â€”, â€”N(H)â€”C(O)â€”N&boxH;C(OH)â€”, â€”N&boxH;CHâ€”C(O)â€”NHâ€”, â€”Oâ€”CH2â€”C(O)â€”NHâ€”, â€”Sâ€”CH2â€”C(O)â€”NHâ€” and â€”N(H)â€”C(O)â€”C(O)â€”N(H)â€”,