Patent ID: 8648037
Filing Date: 2014-02-11
Classification: A61K,A61P,C07K

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is absent, —(C═O)—, —S(O) {circle around (B)} is selected from —C M each R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; or substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) —C L W is absent, —O—, —S—, NH—, —N(Me)—, —C(O)NH—, or —C(O)N(Me)—; X and Y are taken together with the carbon atoms to which they are attached to form a cyclic moiety selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocylic; X′ is N each R R R and R′ are each independently selected from the group consisting of: (i) —C (ii) aryl; substituted aryl; heteroaryl; or substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) hydrogen or deuterium; G is selected from —OH, —NHS(O) R″ is selected from hydrogen, methyl, ethyl, and allyl.