Patent ID: 6734003
Filing Date: 2004-05-11
Classification: A61K,A61P,C12N

Abstract:
An isolated and purified phosphodiesterase polypeptide with phosphodiesterase enzymatic activity encoded by a polynucleotide selected from the group consisting of:a) a polynucleotide comprising the sequence set forth in SEQ ID NO: 1; b) a polynucleotide encoding the polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23; and c) a polynucleotide that hybridizes under moderately stringent conditions to the non-coding strand of the polynucleotide of (a) or (b); said moderately stringent conditions comprising a final wash at 65 degrees C. in 2Ã—SSC and 0.1% SDS.