Patent ID: 9063139
Filing Date: 2015-06-23
Classification: C12Q,C40B,G01N

Abstract:
1. A kit for assessing the risk of development of, or likely progression of, disease characterized by alternative complement cascade disregulation, including macular degeneration, in a human subject, the kit comprising reagents for detecting in a sample from the subject one or more of the polymorphisms or one or more of the allelic variants: a) A or G at rs641153 of the complement factor B (BF) gene, or R or Q at position 32 of the BF protein; b) A or T at rs4151667 of the BF gene, or L or H at position 9 of the BF protein; c) G or T at rs547154 of the C2 gene; and, d) C or G at rs9332379 of the C2 gene, or E or D at position 318 of the C2 protein, wherein said reagents comprise an oligonucleotide probe that detects a said polymorphism, wherein said probe: wherein said oligonucleotide probe is immobilized on a solid support.