Patent ID: 8679473
Filing Date: 2014-03-25
Classification: A61K,A61P,C12N,C12R,Y02A

Abstract:
1. A method of treating a mammal suffering from a physiological and/or pathophysiological condition, the method comprising non-orally administering at least one non-pathogenic and/or attenuated bacterium, wherein said non-pathogenic and/or attenuated bacterium is capable of inducing apoptosis in a tumor-associated macrophage (TAM); wherein (a) apoptosis is induced in tumor-associated macrophages (TAM) and tumor-associated macrophages (TAM) are partially or nearly completely depleted and/or (b) apoptosis is induced in disease-associated macrophages and disease associated macrophages are partially or nearly completely depleted, wherein the at least one bacterium constitutively expresses IpaB, SipB, or a combination thereof.