Patent ID: 8975376
Filing Date: 2015-03-10
Classification: A61P,C07K

Abstract:
1. A humanized anti-α2 integrin antibody comprising: (a) a light chain comprising a light chain variable region (V (b) a heavy chain comprising a heavy chain variable region (V wherein the variant C wherein the at least one amino acid modification comprises amino acid substitution S324N replacing serine at amino acid position 324 of the parent antibody with asparagine, wherein the antibody further comprises amino acid substitution E269D replacing glutamate at amino acid position 269 of the parent antibody with aspartate, and substitution S298A replacing serine at amino acid position 298 of the parent antibody with alanine, wherein the numbering of the amino acid positions is that of the EU index as in Kabat, and wherein the antibody exhibits improved complement dependent cytotoxicity (CDC) or improved CDC and antibody dependent cellular cytotoxicity (ADCC) compared to the parent antibody.