Patent ID: 8716449
Filing Date: 2014-05-06
Classification: A61K,C07K,G01N

Abstract:
1. A monoclonal antibody to human IL-12 p75 heterodimer, said p75 heterodimer comprising a p40 subunit and a p35 subunit, wherein said monoclonal antibody: (a) immunologically reacts with an epitope presented by the p75 heterodimer of human IL-12; and (b) neutralizes at least 90% of the bioactivity of human IL-12 as measured in an IL-12 bioactivity assay in PHA-activated human lymphoblasts by inhibiting IL-12 stimulated proliferation of PHA-activated human lymphoblasts, using an antibody concentration of 0.5 μg/ml and a human IL-12 concentration of 0.25 ng/ml.