Patent ID: 8148118
Filing Date: 2012-04-03
Classification: C12P

Abstract:
1. A method for preparation of chiral epoxy compounds of general formula 2 wherein R 1 represents Me, Et, Ph, 4-(HO)C 6 H 4 , 3-(NO 2 )C 6 H 4 , 4-(Cl)C 6 H 4 , R 2 represents H, Me and R 3 represents H, CH 2 OH, wherein the process steps comprise: stifling the olefin compound of general formula 1 wherein the value of R1, R2, R3 is same as mentioned for formula 2 and immobilized lipase enzyme with 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate in a solvent at a temperature ranging between 20-30° C. at a pH ranging between 3-5, adding urea-hydrogen peroxide adduct as an oxidizing agent portion-wise to the said mixture, filtering the reaction mixture and evaporating the solvent from the filtrate followed by purification of the desired epoxide compound of general formula 2.