Patent ID: 6709646
Filing Date: 2004-03-23
Classification: A61K

Abstract:
A composition of matter having the following formula:IEM-PBM-MS-MM, wherein said IEM comprises a complex between: (1) a chelating agent selected from the group consisting of DTPA, DOTA, DTPA-BMA, and HP-DO3A, and (2) one or more paramagnetic metal ions (M) with atomic numbers 21-29, 42, 44, or 57-83; wherein said -PBM-MS-MM moiety is selected from the group consisting of: â€ƒwherein at least one aryl ring of each member of the group is substituted with a phosphate group; wherein R can be a linear or branched alkyl group having from 1 to 5 carbons, an aryl group, or a cycloalkyl group; and wherein the wavy line signifies the attachment site for the IEM; and wherein said -PBM-MS-MM moiety is conjugated to said IEM via a covalent bond to a methylene carbon of said chelating agent of said IEM.