Patent ID: 8168653
Filing Date: 2012-05-01
Classification: A61K,A61P,C07D

Abstract:
1. A method for inhibiting activation of a hedgehog pathway in a cell, comprising contacting the cell with a compound of formula (I) in a sufficient amount to inhibit hedgehog signalling; wherein, as valence and stability permit, X is —NH—; Z is a direct bond; Y represents —C(═O)—; A represents O, S, or NR G represents cyclohexane, pyridine, phenyl or phenyl fused with 1,3-dioxolane; Ar represents phenyl, pyridine, 1,3-thiazole or thiophene, optionally substituted by halogen, lower alkoxy, lower alkyl or halogenated lower alkyl; R R R J is absent.