Patent ID: 6787552
Filing Date: 2004-09-07
Classification: A61P,C07D

Abstract:
A compound having the following general formula (I) or a salt thereof: wherein R1 is a hydrogen atom, an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms and a halogen atom substituent, an alkenyl group having 2-8 carbon atoms, an alkynyl group having 2-8 carbon atoms, a 3-7 membered cycloalkyl group, an alkyl group having 1-8 carbon atom and a 3-7 membered substituent, an arylalkyl group that has a C6-10 aryl portion and C1-4 alkyl portion and optionally has a substituent, or an aryl or heterocyclic group which optionally has a substituent; R2 is a hydrogen atom, an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms and a halogen atom substituent, an alkenyl group having 2-8 carbon atoms, an alkynyl group having 2-8 carbon atoms, a 3-7 membered cycloalkal group, an alkyl group having 1-8 carbon atom and a 3-7 membered substituent, an arylalkyl group that has a C6-10 aryl portion and C1-4 alkyl portion and optionally has a substituent, or heterocyclic group which optionally has a substituent; A is O, S, or NR5 in which R5 is H or C1-8, alkyl; each of X1 and X2 independently is a bond, O, S(O)p in which p is an integer of 0 to 2, C(&boxH;O), C(&boxH;Nâ€”OR6) in which R6 is H or C1-8, alkyl; C(&boxH;O)NH, NHC(&boxH;O), SO2NH, NHSO2, CH(OR7) in which R7 is H or C1-8 alkyl, CH&boxH;CH, or Câ‰¡C; Y is an alkylene chain having 1-8 carbon atoms and optionally a substituent; Z is O or S; each of R3 and R4 independently is an alkyl group having 1-8 carbon atoms and optionally a substituent; and R8 is a hydrogen atom or an alkyl group having 1-8 carbon atoms; provided that X2 is neither O nor S(O)p when X1 is a bond, while X2 is not a bond when X1 is C(&boxH;O)NH.