Patent ID: 6316260
Filing Date: 2001-11-13
Classification: A61K,C07D,C12N

Abstract:
A tetraether lipid derivative represented by the general formula [I]: ##STR3##wherein each of S.sup.1 and S.sup.2 independently has the following meaning: ##STR4##Y is --NR.sup.2 R.sup.3 or --N.sup.+ R.sup.4 R.sup.5 R.sup.6 ;X.sup.1 and X.sup.2 are independently selected from the group consisting of alkylenes and alkenylenes having 2 to 20 carbon atoms;R.sup.1 to R.sup.2 are independently selected from the group consisting of hydrogen and alkyl, alkenyl, aralkyl, and aryl groups having 1 to 12 carbon atoms, wherein one of R.sup.2 to R.sup.6 can, optionally, further comprise an antibody against cell surface molecules or a ligand for cell surface receptors;each R.sup.10 and R.sup.11 pair are either each --H or, together, a covalent bond;each R.sup.12 and R.sup.13 pair are either each --H or, together, a covalent bond;each R.sup.14 and R.sup.15 pair are either each --H or, together, a covalent bond;each R.sup.16 and R.sup.17 pair are either each --H or, together, a covalent bond; andn is an integer from 0 to 10.