Patent ID: 6403607
Filing Date: 2002-06-11
Classification: A61P,C07C,C07D

Abstract:
A sulfonamide compound represented by the following formula (1): wherein Z represents an imino group, â€”N(R2)â€”(CH2)nâ€”, â€”N(R2)â€”(CH2)nâ€”N(R3)â€”, â€”N(R2)â€”(CH2)nâ€”Oâ€”, â€”N(R2)â€”(CH2)nâ€”Sâ€”, â€”N(R2)â€”(CH2)nâ€”NHSO2â€”, â€”N(R2)â€”CH2CH&boxH;CHâ€”, â€”O(CH2)â€”N(R3)â€”, or â€”N(R2)â€”(CH2)nâ€”Oâ€”CH2â€”;Ar1 represents an aromatic hydrocarbon group, a saturated heterocyclic group or an unsaturated heterocyclic group selected from the group consisting of pyridyl, thienyl, furyl, quinolyl, oxazolyl, thiazolyl, thiadiazolyl, and tetrazolyl. Ar2 represents a phenyl group, an alkyl group, a naphthyl group, a quinolyl group, an isoquinolyl group, a thienyl group, or a pyridyl group, which optionally has one through three substituents selected from among a halogen atom, an alkyl group, an alkoxy group, an acetamido group, and a nitro group; Ra represents a hydrogen atom, a morpholinoyl group, an alkoxy group, or an aminoalkoxy group; Rb represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; Rc represents a hydrogen atom, or an alkyl group or a halogenobenzenesulfonyl group, which optionally has a substituent; R1 represents a hydrogen atom, or R1 and R2 together form a trimethylene group; R2 represents a hydrogen atom, an alkyl group, a dialkylaminoalkyl group, a benzyl group, a halogenophenyl group, or a halogenobenzenesulfonyl group, R2 and R1 together form a trimethylene group, or R2 and R3 together for an ethanedioyl group or an alkylene group; R3 represents a hydrogen atom, an alkyl group, a hydroxyoxalyl group, an alkanoyl group, a sulfonyl group, an alkoxycarbonyl group, or a halogenobenzenesulfonyl group, or R3 and R2 together form an ethanedioyl group or an alkylene group; n is a number of 2-4; and Z is not â€”N(R2)â€”CH2â€”CH&boxH;CHâ€” when Ar2 is an isoquinolyl group, or a pharmaceutically acceptable salt thereof.