Patent ID: 8738338
Filing Date: 2014-05-27
Classification: A61K,C07K,G01N

Abstract:
1. A method of guiding a human subject's sleep schedule, comprising: a) measuring the concentration of each of two peptides, GGHPPPP (SEQ ID NO:1) and ESPSLIA (SEQ ID NO:2), in a saliva sample taken from the subject; b) calculating the ratio of the concentration of GGHPPPP (SEQ ID NO:1) to the concentration of ESPSLIA (SEQ ID NO:2) measured in (a) according to the equation: c) having the subject initiate or resume a sleep schedule; d) measuring the concentration of each of two peptides, GGHPPPP (SEQ ID NO:1) and ESPSLIA (SEQ ID NO:2), in a saliva sample taken from the subject at one or more time points after (c); e) calculating the ratio of the concentration of GGHPPPP (SEQ ID NO:1) to the concentration of ESPSLIA (SEQ ID NO:2) for each sample measured in (d) according to the equation: f) guiding the subject's sleep schedule by modifying the duration of subsequent sleep periods using the subject's ratio(s) as calculated in (e), such that a decrease in the ratio relative to the previous ratio as calculated in either (b) or (e) leads to a subsequent increase in the duration of the subject's sleep period, and an increase in the ratio or a constant ratio relative to the previous ratio as calculated in either (b) or (e) leads to no change in the duration of the subject's sleep period or a subsequent decrease in the duration of the subject's sleep period.