Patent ID: 6977295
Filing Date: 2005-12-20
Classification: A01K,C12N

Abstract:
1. A composition comprising a double D-loop, said double-D loop comprising: a target nucleic acid; a first single stranded targeting polynucleotide comprising: a central region and two flanking regions which flank the central region of said first single stranded targeting polynucleotide and which form homology clamps with said target nucleic acid; a second single stranded targeting polynucleotide comprising: a central region and two flanking regions which flank the central region of said second single stranded targeting polynucleotide and which form homology clamps with said target nucleic acid; and a locking complex formed by the central regions of said first and said second single stranded polynucleotides, wherein said locking complex is a triplex or a quadruplex.