Patent ID: 6441022
Filing Date: 2002-08-27
Classification: A61K,C07D,C07K,C08G

Abstract:
A composition comprising one or more compounds of formula I in whichR1 is methyl, ethyl, propyl, or butyl; R2 is H, OH, NH2, or NH-(C1-C6)-alkyl; R3 is a sugar radical, a disugar radical, a trisugar radical, a tetrasugar radical, wherein said radicals are optionally mono- or polysubstituted by a sugar protective group; R4is methyl, ethyl, propyl, or butyl; R5 is methyl, ethyl, propyl, or butyl; Z is â€”(C&boxH;O)n-(C0-C16)-alkyl, â€”(C&boxH;O)n-(C0-C16)-alkyl-N Hâ€”, â€”(C&boxH;O)n-(C0-C16)-alkyl-Oâ€”, â€”(C&boxH;O)n-(C1-C16)-alkyl-(C&boxH;O)m, or a covalent bond; n is 0 or 1; m is 0 or 1; or a pharmaceutically tolerable salt thereof, or a physiologically functional derivative thereof, and which also comprises one or more of simvastain, fluvastatin, pravastatin, cerivastatin, lovastatin and atorvastatin.