Patent ID: 7227028
Filing Date: 2007-06-05
Classification: A61P,C07D

Abstract:
1. A method of synthesizing a 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonate compound of Formula (I), comprising: (i) contacting a compound of Formula (IV) and a compound of Formula (V) to provide a compound of Formula (VI); (ii) contacting the compound of Formula (VI) with a carboxylate compound of Formula (VII) to provide an acyloxyalkyl thiocarbonate compound of Formula (VIII); and (iii) contacting the thiocarbonate compound of Formula (VIII) with an oxidant (IX), in the presence of an N-hydroxysuccinimide compound of Formula (X) to afford the compound of Formula (I); wherein: X is Cl, Br or I; B B R R R