Patent ID: 6620828
Filing Date: 2003-09-16
Classification: A61P,C07D,C07F

Abstract:
A compound of the Formula I: wherein:R1 is hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or a group of the formula R6â€”CO or R6â€”CS where R6 is substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, alkenyl, aryl, heteroaryl, alkoxy, or Nâ€”R7R8 where R7R8 are each independently hydrogen or substituted or unsubstituted alkyl, aryl, or heteroaryl; R2 is hydroxy, halo, cyano, or nitro, or substituted or unsubstituted alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or a group of the formula (A): where Ra is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, ora group of the formula (B): where Ra is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, ora group of the formula (C): where Rb and Rc are independently hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, ora group of the formula (D): where Rd is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, or acylamino, and Re is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, alkylamino, or dialkylamino, ora group of the formula (E): where Rf is substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, ora group of the formula (F): where Rg and Rh are each independently hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, ora group of the formula (G): where Ri is alkyl or substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or a group of formula (A), formula (B), formula (C), formula (H), or formula (I), ora group of the formula (H) where Rj is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, or amino, or a group of formula (A), formula (B), formula (C) or formula (D), and Rk is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or a group of formula (A), formula (B), formula (C), formula (D), formula (E), or formula (F), ora group of the formula (I) where Rl is hydrogen or substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or a group of formula (C),or R2 is a substituted or unsubstituted cycloalkyl, heterocycloalkyl, or aryl that is fused to Q;X is C or N; and Q is a divalent radical having 2 or 3 ring atoms each independently selected from C, N, O, S, Câ€”R5 and Nâ€”R5, where R5 hydroxy, halo, cyano, or amino, or substituted or unsubstituted alkyl, aryl, heteroaryl, alkoxy, which together with C* and N* form a five- or six-membered aromatic or nonaromatic ring; or a pharmaceutically acceptable prodrug, or pharmaceutically acceptable salt thereof.