Patent ID: 8455205
Filing Date: 2013-06-04
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting an interaction between Matrix Metalloproteinase-9 (MMP-9) and an MMP-9 substrate, the method comprising: contacting an MMP-9 binding protein with MMP-9 in the presence of an MMP-9 substrate, wherein the MMP-9 binding protein comprises at least one immunoglobulin variable region, wherein the MMP-9 binding protein comprises heavy chain variable domain comprising a HC-CDR1 comprising the amino acid sequence of SEQ ID NO: 956, a HC-CDR2 comprising the amino acid sequence of SEQ ID NO: 957, a HC-CDR3 comprising the amino acid sequence of SEQ ID NO: 958, and a light chain variable region comprising an LC-CDR1 comprising the amino acid sequence of SEQ ID NO: 953, a LC-CDR2 comprising the amino acid sequence of SEQ ID NO: 954, and a LC-CDR3 region comprising the amino acid sequence of SEQ ID NO: 955, and wherein the binding protein binds to MMP-9 and thereby inhibits the binding of the MMP-9 substrate to MMP-9.