Patent ID: 8993235
Filing Date: 2015-03-31
Classification: B01L,C12Q,G01N,Y10S

Abstract:
1. A method of treating a biological specimen on an analytic substrate, comprising: disposing a liquid mixture upon an analytic substrate having a biological specimen disposed thereon and a residual wash buffer with at least one detergent present in the buffer disposed over the biological specimen, the liquid mixture comprising an oil-based carrier solution having dispersed therein a quantity of at least one of a plurality of microcapsules and a plurality of nanocapsules encapsulating at least one of a DNA probe and a RNA probe disposed in an aqueous solution containing at least one detergent; and disrupting the at least one of a plurality of microcapsules and a plurality of nanocapsules to cause the release of the at least one of DNA probe and RNA probe and the aqueous solution into the oil-based carrier solution such that at least one of the DNA probe and the RNA probe and the aqueous solution separate from the oil-based carrier solution so as to become available to act on or react with the biological specimen and the residual wash buffer.