Patent ID: 8138199
Filing Date: 2012-03-20
Classification: A61P,C07D

Abstract:
1. A method of inhibiting JAK2 kinase activity in a subject wherein the subject has a myeloproliferative disorder, comprising administering to the subject with a myeloproliferative disorder an effective amount of a compound having the structure (A): wherein: X is selected from a group consisting of a bond, O and CH each of R each of p, q, r, n, m is independently an integer having the value between 0 and 6, each R G each G is independently CR R each of R A is selected from a group consisting of NH, and N—(C G G R wherein alkyl, alkenyl, alkynyl, cycloalkyl, or heterocycle, for each occurrence if any, are optionally substituted by one or more substituents selected from the group consisting of hydroxy, alkoxy, mercapto, halogen, cyano, nitro, amino, amido, aldehyde, acyl, oxyacyl, carboxyl, sulfonyl, sulfonamide, or sulfuryl; or a pharmaceutically acceptable salt thereof.