Patent ID: 6207674
Filing Date: 2001-03-27
Classification: A61K,A61P

Abstract:
A method of weaning a patient from long-term use of a habit-forming narcotic drug, comprising administering to the patient a combination of dextromethorphan and a second drug which suppresses oxidation of dextromethorphan by cytochrome oxidase enzyme P450-2D6, wherein:a. the second drug is administered at an effective concentration which increases measurable levels of dextromethorphan in the patient's blood;b. the dextromethorphan is administered at a therapeutically effective concentration which, when coadministered with the second drug, allows the patient to reduce his or her dosage of a habit-forming narcotic drug, without intolerable adverse effects, during a gradual weaning process; and,c. the dextromethorphan and the second drug are co-administered to the patient in a manner which allows the patient to decrease and then stop taking the habit-forming narcotic drug without suffering intolerable adverse effects.