Patent ID: 6258775
Filing Date: 2001-07-10
Classification: A61P,C07C

Abstract:
Biaromatic compounds, which have the general formula (I) below: ##STR7##in which:R.sub.1 represents(i) the radical --CH.sub.3,(ii) the radical --CH.sub.2 --O--R.sub.5,(iii) the radical --O--R.sub.5,(iv) the radical --CO--R.sub.6,R.sub.5 and R.sub.6, having the meanings given below,Y represents a radical chosen from the radicals of formulae (a) and (b) below: ##STR8##R.sub.7 and R'.sub.7 having the meanings given below,Ar represents a radical chosen from the radicals of formulae (c) to (f) below: ##STR9##in which the radical Y is in an ortho or meta position relative to the radical X, X andY of these formulae referred to as X and Y in formula (I),R.sub.8 having the meaning given below,X represents an oxygen or sulphur atom, a radical --SO--, --SO.sub.2 --, --N(R.sub.9)-- or a radical chosen from the radicals of formulae (g) to (r) below: ##STR10##R.sub.5, R.sub.9 and n having the meanings given below,R.sub.2 and R.sub.3, which may be identical or different, are chosen from the group consisting of:(i) a hydrogen atom,(ii) an alkyl radical having at least 3 carbon atoms, among which the carbon attached to the phenyl radical of formula (I) is substituted with at least two carbon atoms,(iii) a linear or branched alkyl radical,(iv) a radical --OR.sub.5,(v) a radical --SR.sub.5,(vi) a polyether radical,wherein R.sub.2 and R.sub.3, taken together, optionally form, with the adjacent aromatic ring, a 5- or 6-membered ring, optionally substituted with methyl groups and/or optionally interrupted by an oxygen or sulphur atom,with the proviso that, when R.sub.2 and R.sub.3, as defined above, do not form a ring, at least one of the radicals R.sub.2 and R.sub.3 has a meaning (ii) mentioned above,R.sub.4 and R.sub.8, which may be identical or different, represent a hydrogen atom, a halogen atom, a linear or branched alkyl radical, a radical --OR.sub.5, a polyether radical,R.sub.5 represents a hydrogen atom, a lower alkyl radical or a radical --COR.sub.10,R.sub.10 having the meaning given below, R.sub.6 represents(a) a hydrogen atom(b) a lower alkyl radical(c) a radical of formula: ##STR11##R' and R"" having the meanings given below,(d) a radical --OR.sub.11R.sub.11 having the meaning given below,R.sub.7, R'.sub.7 and R.sub.9, which may be identical or different, represent a hydrogen atom or a lower alkyl radical,n is an integer equal to 0 or 1,R.sub.10 represents a lower alkyl radical,R.sub.11 represents a hydrogen atom, a linear or branched alkyl radical, an alkenyl radical, a mono- or polyhydroxyalkyl radical, an aryl or aralkyl radical, optionally substituted, a sugar residue or an amino acid or peptide residue,R.sub.12 represents a lower alkyl radical,R' and R"", which may be identical or different, represent a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid, peptide or sugar residue, or alternatively, taken together, form a heterocycle, and the optical and geometrical isomers of the said compounds of formula (I), as well as their salts.