Patent ID: 6221888
Filing Date: 2001-04-24
Classification: A61K,C07K

Abstract:
A compound having the formula Ia: ##STR8##or a pharmaceutically acceptable salt thereof, whereinR.sup.2 is 1) hydrogen, or2) C.sub.1-6 alkyl;one of R.sup.3 and R.sup.4 is hydrogen and the other is1) aryl,2) heteroaryl,3) aryl-C.sub.1-10 alkyl,4) heteroaryl-C.sub.1-10 alkyl, or5) C.sub.1-10 alkyl,wherein aryl and heteroaryl are each optionally substituted with one to four substituents selected from R.sup.b ; and alkyl is optionally substituted with one to four substituents independently selected from R.sup.a ; orR.sup.3, R.sup.4 and the carbon to which they are attached form a 3-7 membered mono- or bicyclic ring containing 0-2 heteroatoms selected from N, O and S; one of R.sup.6 and R.sup.7 is hydrogen and the other is1) aryl,2) aryl-C.sub.1-10 alkyl, or3) C.sub.1-10 alkyl,wherein aryl is optionally substituted with one to four substituents independently selected from R.sup.y, and alkyl is optionally substituted with one to four substituents selected from R.sup.x ; andR.sup.a is 1) Cy, or2) a group selected from R.sup.x ;wherein Cy is optionally substituted with one to four substituents independently selected from R.sup.c ;R.sup.b is 1) a group selected from R.sup.a,2) C.sub.1-0 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) aryl C.sub.1-10 alkyl,6) heteroaryl C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl are optionally substituted with a group independently selected from R.sup.c ;R.sup.c is 1) halogen,2) amino,3) carboxy,4) C.sub.1-4 alkyl,5) C.sub.1-4 alkoxy,6) aryl,7) aryl C.sub.1-4 alkyl, or8) aryloxy;R.sup.d and R.sup.e are independently selected from hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, Cy and Cy C.sub.1-10 alkyl, wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R.sup.c ; or R.sup.d and R.sup.e together with the atoms to which they are attached form a heterocyclic ring of 5 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen;R.sup.f and R.sup.g are independently selected from hydrogen, C.sub.1-10 alkyl, Cy and Cy C.sub.1-10 alkyl; or R.sup.f and R.sup.g together with the carbon to which they are attached form a ring of 5 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen;R.sup.x is 1) --OR.sup.d,2) --NO.sub.2,3) halogen4) --S(O).sub.m R.sup.d,5) --SR.sup.d,6) --S(O).sub.2 OR.sup.d,7) --S(O).sub.m NR.sup.d R.sup.e,8) --NR.sup.d R.sup.e,9) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,10) --C(O)R.sup.d,11) --CO.sub.2 R.sup.d,12) --CO.sub.2 (CR.sup.f R.sup.g).sub.n CONR.sup.d R.sup.e,13) --OC(O)R.sup.d,14) --CN,15) --C(O)NR.sup.d R.sup.e,16) --NR.sup.d C(O)R.sup.e,17) --OC(O)NR.sup.d R.sup.e,18) --NR.sup.d C(O)OR.sup.e,19) --NR.sup.d C(O)NR.sup.d R.sup.e,20) --CR.sup.d (N--OR.sup.e), or21) --CF.sub.3 ;R.sup.y is 1) a group selected from R.sup.x,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) aryl C.sub.1-10 alkyl,6) heteroaryl C.sub.1-10 alkyl,7) cycloalkyl,8) heterocyclyl;wherein alkyl, alkenyl, alkynyl and aryl are each optionally substituted with one to four substituents independently selected from R.sup.x ;Cy is cycloalkyl, heterocyclyl, aryl, or heteroaryl;m is an integer from 1 to 2; andn is an integer from 1 to 10.