Patent ID: 6331560
Filing Date: 2001-12-18
Classification: A61K,A61P,Y02A

Abstract:
A method for septic shock syndrome prophylaxis by preventing production of tumor necrosis factor by administering to a patient in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula (I): ##STR4##having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, whereinA - - - - - B indicates an optional 1(2) or 6(1) double bond,R is(a) --Q wherein Q is a heterocyclic moiety having a labile hydrogen atom so that said moiety acts as a carboxylic acid analogue,(b) --R'X wherein R' is C.sub.1 -C.sub.5 alkyl and X is halogen, --OR"" wherein R"" is hydrogen, C.sub.1 -C.sub.5 alkyl, or --OC(O)R'"" wherein R'"" is hydrogen or C.sub.1 -C.sub.5 alkyl,(c) --R'N(R"").sub.2 wherein R' is C.sub.1 -C.sub.5 alkyl and each R"", which may be the same or different, is hydrogen or C.sub.1 -C.sub.5 alkyl optionally containing a terminal --OR'"" or --OC(O)R'"" moiety wherein R'"" is hydrogen or(d) --R' wherein R' is C.sub.1 -C.sub.5 alkyl,(e) --R'OR'"" wherein R' is C.sub.1 -C.sub.5 alkyl and R'"" is hydrogen or C.sub.1 -C.sub.5 alkyl, or,(f) --R'--C(O)--OR""', wherein R' may be absent and R' and R""' are as defined above;G is(a) halogen,(b) C.sub.1 -C.sub.5 alkyl, or(c) --OR.sub.1 wherein R.sub.1 is(a') --R"", wherein R"" is hydrogen or C.sub.1 -C.sub.5 alkyl optionally containing a terminal --OR'"" or --OC(O)R'"" moiety wherein R'"" is hydrogen or C.sub.1 -C.sub.5 alkyl, or(b') --C(O)R'"" wherein R'"" is as previously defined; andR.sub.2 is(a) C.sub.1 -C.sub.12 alkyl,(b) --OR"""", in which R"""" is a straight chain or branched C.sub.2 -C.sub.9 alkyl which may be substituted at the terminal carbon atom by a phenyl group, or(c) --(CH.sub.2).sub.n OR'"" wherein n is an integer of 1 to 7 and R'"" is hydrogen or C.sub.1 -C.sub.5 alkyl.