Patent ID: 6593480
Filing Date: 2003-07-15
Classification: A61P,C07D

Abstract:
A compound having formula I or a pharmaceutically acceptable salt or prodrug thereof, whereinR1 is selected from the group consisting of (1) alkanoyl, cyano, halo, hydroxy; (2) alkyl, alkenyl, alkynyl, alkoxy, alkanoyloxy; wherein each group defining (2) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkoxycarbonyl, amino, carboxamido, cyano, halo, hydroxy, oxo, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heterocyclyl; wherein the substituted aryl, substituted heteroaryl, and the substituted heterocyclyl groups are optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, perfluoroalkyl, and perfluoroalkoxy; (3) cycloalkyl, aryl, heteroaryl, heterocyclyl; wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxy, alkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, oxo, perfluoroalkyl, and perfluoroalkoxy; (4) CO2R12, OR12, SR12, S(O)R12, and SO2R12; wherein R12 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl; wherein each group can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkoxyalkoxy, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy; R2 is selected from hydrogen and R1; or R1 and R2 together are â€”X1â€”Y1â€”Z1â€”, wherein X1 is selected from a covelent bond, O and CH2;Y1 is selected from C(O), alkylene, and alkenylene; and Z1 is selected from CH2, CH2O, CH2NR13, NR13, and O;wherein R13 is selected from (1) hydrogen; (2) alkyl; wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkoxy, cycloalkyl, aryl, halo; and (3) aryl; R3, R4, R7, R8, and R9 are independently selected from hydrogen and R1; L is selected from a covalent bond and alkylene; R5 is selected from; (1) alkanoyl, alkoxy, alkenyloxy, alkynyloxy, alkoxycarbonyl, cyano; (2) aryl, arylalkyl, heteroaryl, and heterocyclyl; wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkanoylamino, alkanoylaryloxy, alkyl, alkylsulfonamido, alkenyl, alkenyloxy, alkynyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxyalkynyl, alkoxyaryl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkenyloxy, amino, aminoalkyl, aminoaryl, aryl, arylalkyl, arylalkenyl, arylalkynyl, aryloxy, arylsulfonamido, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, carboxyaryl, cyano, cyanoalkyl, heteroaryl, (heteroaryl)heteroarylsulfonamido, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, halo, haloalkyl, haloalkylsulfonamido, nitro, oxo, perfluoroalkyl, perfluoroalkoxy and trialkylsilylalkyl; (3) alkyl, alkenyl, alkynyl, cycloalkyl; wherein each group defining (3) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkenyloxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, halo, hydroxy, and oxo; R6 is selected from hydrogen and alkyl; or -L-R5 and R6 together are selected from wherein d is 1-4 and A is selected from CH2, O, S, SO2, and NR13 and wherein the carbonâ€”carbon double bond of (2) can be in the E or Z configuration and R26 is selected from; (1) alkyl; wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkynyl, alkoxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, heteroaryl, heterocyclyl, hydroxy, and halo; (2) aryl, heteroaryl, heterocyclyl, cycloalkyl, and cycloalkenyl; wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy; R10 and R11 are independently selected from; (1) hydrogen; (2) alkyl; wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from (a) alkenyl, (b) alkynyl, (c) alkoxy, (d) aryl, (e) cycloalkyl, (f) heteroaryl, (g) heterocyclyl, (h) alkoxycarbonyl, (i) carboxy, and () halo; wherein (a)-(c) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo; and wherein (d)-(g) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl; alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy; (3) aryl, cycloalkyl, heteroaryl, heterocyclyl; wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy; (4) â€”SO2R35 and â€”C(O)R36; wherein R35 and R36 are independently selected from (a) alkoxy, amino; (b) alkyl, alkenyl; wherein each group defining (b) can be optionally substituted with 1-4 substituents independently selected from (i) alkenyl, (ii) alkynyl, (iii) alkoxy, (iv) aryl, (v) cycloalkyl, (vi) heteroaryl, (vii) heterocyclyl, (viii) alkoxycarbonyl, (ix) carboxy, and (x) halo; wherein (i)-(iii) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo; and wherein (iv)-(vii) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy; (c) aryl, cycloalkyl, heteroaryl, heterocyclyl; wherein each group defining (c) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxy, alkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy.