Patent ID: 6987123
Filing Date: 2006-01-17
Classification: A61P,C07D,G06F,G09G

Abstract:
1. A compound of formula (I): their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, wherein one or more groups R 1 , R 2 , R 3 , R 4 may be same or different and represent hydrogen, halogen, perhaloalkyl, hydroxy, thio, amino, nitro, cyano, formyl, amidino, guanidino, substituted or unsubstituted groups selected from linear or branched (C 1 -C 12 )alkyl, linear or branched (C 2 -C 12 )alkenyl, (C 3 -C & )cycloalkyl, (C 3 -C & )cycloalkenyl, bicycloalkyl, bicycloalkenyl, (C 1 -C 12 )alkoxy, cyclo(C 3 -C & )alkoxy, aryl, aryloxy, aralkyl, ar(C 1 -C 12 )alkoxy, heterocyclyl, heteroaryl, heterocyclyl(C 1 -C 12 )alkyl, heteroar(C 1 -C 12 )alkyl, heteroaryloxy, heteroar(C 1 -C 12 )alkoxy, heterocyclyloxy, heterocyclylalkyloxy, acyl, acyloxy, acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, heterocyclylalkoxycarbonyl, heteroaryloxycarbonyl, heteroaralkoxycarbonyl, heterocyclyloxycarbonyl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, (C 1 -C 12 )alkylthio, thio(C 1 -C 12 )alkyl, arylthio, (C 1 -C 12 )alkoxycarbonylamino, aryloxycarbonylamino, aralkyloxycarbonylamino, aminocarbonylamino, alkylaminocarbonylamino, alkylamidino, alkylguanidino, dialkylguanidino, hydrazino, alkyl hydrazino, alkoxyamino, hydroxylamino, derivatives of sulfenyl and sulfonyl groups, carboxylic acid and derivatives of carboxylic acids selected from CONH 2 , alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl; aralkylaminocarbonyl; heteroarylaminocarbonyl and heteroaralkylamino carbonyl groups; heterocyclylaminocarbonyl groups; sulfonic acid and its derivatives selected from SO 2 NH 2 , SO 2 NHMe, SO 2 NMe 2 , SO 2 NHCF 3 , SO 2 NHCO(C 1 -C 6 )alkyl, SO 2 NHCOaryl groups, phosphonic acid and its derivatives selected from P(O)(OH) 2 , P(O)(O C 1 -C 6 alkyl) 2 , P(O)(O aryl) 2 , P(O)(OH) (O C 1 -C 6 alkyl) groups; or the adjacent groups R 2 and R 3 together may form a five or a six membered ring, optionally containing one or more double bonds and optionally containing one or more heteroatoms selected from O, N, or S; n is an integer ranging from 1 to 8; W represents O, S or NR 9 where R 9 represents hydrogen, (C 1 -C 12 )alkyl or aryl; Ar represents a substituted or unsubstituted divalent single or fused aromatic, heteroaromatic or heterocyclic group; R 5 and R 6 represent both hydrogen or together represent a bond; R 5 and R 6 may also represent a hydroxy, (C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxy, halogen, acyl, substituted or unsubstituted aralkyl group; X represents O or S; R 7 represents hydrogen, perfluoro(C 1 -C 12 )alkyl, substituted or unsubstituted groups selected from (C 1 -C 12 )alkyl, cyclo(C 1 -C 12 )alkyl, aryl, ar(C 1 -C 12 )alkyl, heteroaryl, heteroar(C 1 -C 12 )alkyl, heterocyclyl, alkoxyalkyl, aryloxyalkyl, alkoxycarbonyl, aryloxycarbonyl. cycloalkyloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, acyl groups; Y represents O or S; Z represents oxygen, sulfur or NR 10 , where R 10 represents hydrogen or substituted or unsubstituted groups selected from (C 1 -C 12 )alkyl, aryl, ar(C 1 -C 12 )alkyl, hydroxy(C 1 -C 12 )alkyl. ammo(C 1 -C 12 )alkyl, heteroaryl, heteroar(C 1 -C 12 )alkyl groups; R 8 represents hydrogen, substituted or unsubstituted groups selected from (C 1 -C 12 )alkyl, aryl, ar(C 1 -C 12 )alkyl, heteroaryl, heteroar(C 1 -C 12 )alkyl, heterocyclyl, heterocyclylalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl groups; R 10 and R 8 together may form a 5 or 6 membered substituted or unsubstituted cyclic ring structure containing carbon atoms or containing one or more heteroatoms selected from O, N and S.