Patent ID: 6486315
Filing Date: 2002-11-26
Classification: A61P,C07D

Abstract:
A recrystallization and reprocessing process for the mercaptoalkanoylamino lactam acid of the formula whereinX1 is a lactam of the formula R1 is straight or branched chain alkyl of 1 to 6 carbons, â€”(CH2)m-aryl, â€”(CH2)m-substituted aryl, or â€”(CH2)m-heteroaryl; m is zero or an integer from 1 to 6; n is zero or one; d is zero or one; v is one or two; Y5 is â€”CH2â€”, â€”Sâ€”, or â€”Oâ€” provided that Y5 is â€”Sâ€”or â€”Oâ€”only when d is one; Y6 is â€”Sâ€” or â€”Oâ€”; R4 and R5 are both hydrogen; R6 and R7 are both methyl; q is two; R10 and R11 are both hydrogen; and b is zero; which comprises adding the mercaptoalkanoylamino lactam acid of forula I to a solvent containing a sufficient amount of an agent that minimizes the amount of the disulfide of the formula which, in turn, minimizes the formation of the undesired epimer of the pharmaceutically active compound of formula I and then subjecting the resulting slurry to changes in temperature and/or pH, optionally filtering, and then changing the temperature and/or pH to effect recrystallization.