Patent ID: 6770647
Filing Date: 2004-08-03
Classification: A61P,C07D

Abstract:
A compound of formula I, II or III: or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein;A is selected from: â€”C(O)NHOH, â€”C(O)NHOR5, â€”C(O)NHOR6, â€”N(OH)COR5, â€”N(OH)CHO, and â€”CH2SH; ring C is substituted with 0-1 R3 and 0-1 R4; R1 is Uâ€”Xâ€”Yâ€”Zâ€”Uaâ€”Xaâ€”Yaâ€”Za; U is selected from: C(O), C(O)O, C(O)NRa1, S(O)p, and S(O)pNRa1; X is absent or is selected from: C1-10 alkylene, C2-10 alkenylene, and C2-10 alkynylene; Y is absent or is selected from: O, NRa1, S(O)p, and C(O); Z is selected from: a C3-13 carbocycle substituted with 0-5 Rb; and a 5-14 membered heterocycle consisting of carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-5 Rb; Ua is absent or is selected from: O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)O, OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, NRa1S(O)p, and NRa1SO2NRa1; Xa is absent or is selected from: C1-4 alkylene, C2-4 alkenylene, and C2-4 alkynylene; Ya is absent or is selected from: O, NRa1, S(O)p, and C(O); provided that Uaâ€”Xaâ€”Ya forms a spacer of two or more atoms, other than â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”; Za is selected from: a C3-13 carbocycle substituted with 0-5 Rc; and a 5-14 membered heterocycle consisting of carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-5 Rc; provided that U, Y, Z, Ua, Ya, and Za do not combine to form a Nâ€”N, Nâ€”O, Oâ€”N, Oâ€”O, S(O)pâ€”O, Oâ€”S(O)p or S(O)pâ€”S(O)p group; R3 is selected from: H, C1-6 alkyl substituted with 0-1 Rb, C2-6 alkenyl substituted with 0-1 Rb, C2-6 alkynyl substituted with 0-1 Rb, C3-10 carbocycle substituted with 0-2 Rb, â€”(CH2)râ€”C3-10 carbocycle substituted with 0-2 Rb, and â€”(CH2)r-5-10 membered heterocycle consisting of carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-2 Rb; R4 is selected from: H, C1-6 alkyl substituted with 0-1 Rb, C2-6 alkenyl substituted with 0-1 Rb, C2-6 alkynyl substituted with 0-1 Rb, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, NRaC(O)Ra, C(S)NRaRa1, NRaC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra3, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra3, S(O)pRa3, CF3, OCF3, and CF2CF3; Ra, at each occurrence, is independently selected from: H and C1-6 alkyl; Ra1, at each occurrence, is independently selected from: H, C1-6 alkyl substituted with 0-1 Rc1, C2-6 alkenyl substituted with 0-1 Rc1, C2-6 alkynyl substituted with 0-1 Rc1, and â€”(CH2)r-3-8 membered carbocyclic or heterocyclic ring consisting of carbon atoms and 0-2 ring heteroatoms selected from N, NRa2, O, and S(O)p and substituted with 0-3 Rc1; alternatively, Ra and Ra1 when attached to a nitrogen are taken together with the nitrogen to which they are attached form a 5 or 6 membered heterocycle consisting of carbon atoms and from 0-1 additional heteroatoms selected from N, NRa2, O, and S(O)p; Ra2, at each occurrence, is independently selected from: C1-4 alkyl, phenyl, and benzyl; Ra3, at each occurrence, is independently selected from: H, C1-6 alkyl substituted with 0-1 Rc1, C2-6 alkenyl substituted with 0-1 Rc1, C2-6 alkynyl substituted with 0-1 Rc1, â€”(CH2)r-3-8 membered carbocyclic or heterocyclic ring consisting of carbon atoms and 0-2 ring heteroatoms selected from N, NRa2, O, and S(O)p and substituted with 0-3 Rc1; Rb, at each occurrence, is independently selected from: C1-6 alkyl substituted with 0-1 Rc1, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, NRaC(O)Ra, C(S)NRaRa1, NRaC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra3, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra3, S(O)pRa3, CF3, OCF3, CF2CF3, CHF2, CH2F, and phenyl; Rc, at each occurrence, is independently selected from: H, C1-6 alkyl substituted with 0-2 Rc1, C2-6 alkenyl substituted with 0-2 Rc1, C2-6 alkynyl substituted with 0-2 Rc1, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, CF3, CF2CF3, CH2F, CHF2, (CRaRa1)nNRaRa1, (CRaRa1)nC(&boxH;NCN)NRaRa1, (CRaRa1)nC(&boxH;NRa)NRaRa1, (CRaRa1)nC(&boxH;NORa)NRaRa1, (CRaRa1)nC(O)NRaOH, (CRaRa1)nC(O)Ra1, (CRaRa1)nC(O)ORa1, (CRaRa1)nC(S)ORa1, (CRaRa1)nC(O)NRaRa1, (CRaRa1)nNRaC(O)Ra1, (CRaRa1)nC(S)NRaRa1, (CRaRa1)nOC(O)NRaRa1, (CRaRa1)nNRaC(O)ORa1, (CRaRa1)nNRaC(O)NRaRa1, (CRaRa1)nS(O)pRa3, (CRaRa1)nSO2NRaRa1, (CRaRa1)nNRaSO2Ra3, (CRaRa1)nNRaSO2NRaRa1, â€”(CRaRa1)nâ€”C3-10 carbocycle substituted with 0-2 Rc1, and â€”(CRaRa1)n-5-14 membered heterocycle consisting of carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-2 Rc1; Rc1, at each occurrence, is independently selected from: H, C1-4 alkyl, ORa, Cl, F, Br, I, &boxH;O, CF3, â€”CN, NO2, C(O)Ra, C(O)ORa, C(O)NRaRa, and S(O)pRa; R5, at each occurrence, is selected from: C1-10 alkyl substituted with 0-2 Rb, and C1-8 alkyl substituted with 0-2 Re; Re, at each occurrence, is selected from: phenyl substituted with 0-2 Rb and biphenyl substituted with 0-2 Rb; R6, at each occurrence, is selected from: phenyl, naphthyl, C1-10 alkyl-phenyl-C1-6 alkyl-, C3-11 cycloalkyl, C1-6 alkylcarbonyloxy-C1-3 alkyl-, C1-6 alkoxycarbonyloxy-C1-3 alkyl-, C2-10 alkoxycarbonyl, C3-6 cycloalkylcarbonyloxy-C1-3 alkyl-, C3-6 cycloalkoxycarbonyloxy-C1-3 alkyl-, C3-6 cycloalkoxycarbonyl, phenoxycarbonyl, phenyloxycarbonyloxy-C1-3 alkyl-, phenylcarbonyloxy-C1-3 alkyl-, C1-6 alkoxy-C1-6 alkylcarbonyloxy-C1-3 alkyl-, [5-(C1-C5 alkyl)-1,3-dioxa-cyclopenten-2-one-yl]methyl, [5-(Ra)-1,3-dioxa-cyclopenten-2-one-yl]methyl, (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyl, â€”C1-10 alkyl-NR7R7a, â€”CH(R8)OC(&boxH;O)R9, and â€”CH(R8)OC(&boxH;O)OR9; R7 is selected from: H, C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-; R7a is selected from H, C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-; R8 is selected from H and C1-4 linear alkyl; R9 is selected from H, C1-8 alkyl substituted with 1-2 Rf, C3-8 cycloalkyl substituted with 1-2 Rf, and phenyl substituted with 0-2 Rb; Rf, at each occurrence, is selected from: C1-4 alkyl, C3-8 cycloalkyl, C1-5 alkoxy, and phenyl substituted with 0-2 Rb; n, at each occurrence, is selected from: 0, 1, 2, 3, and 4; p, at each occurrence, is selected from: 0, 1, and 2; and r, at each occurrence, is selected from: 0, 1, 2, 3, and 4; provided that: (iv) when U is SO2, then Uaâ€”Xaâ€”Ya is other than â€”OCH2â€”Câ‰¡Câ€”, â€”NHCH2â€”Câ‰¡Câ€”, â€”CH2CH2â€”Câ‰¡Câ€” or â€”SCH2â€”Câ‰¡Câ€”; (v) when U is SO2 and Z is phenyl, then Ua is other than OC(O).