Patent ID: 8808746
Filing Date: 2014-08-19
Classification: A61K

Abstract:
1. A process for preparing a microsphere delivery system comprising: (a) dissolving a biodegradable polymer in a first organic solvent that is immiscible with water to produce a first mixture; (b) dissolving an active agent in a second organic solvent that is miscible with water to produce a second mixture, wherein the active agent is a protein or a peptide; (c) producing a third mixture by separately dissolving a basic amino acid in either (i) a third organic solvent that is miscible with water, or (ii) a mixture of said second organic solvent and said third organic solvent, wherein said basic amino acid is selected from the group consisting of arginine, lysine, and histidine, and wherein said second organic solvent and said third organic solvent are different; (d) mixing together said first mixture, said second mixture and said third mixture to prepare a homogeneous organic dispersed phase; (e) emulsifying said homogeneous organic dispersed phase to produce microdroplets; and (f) removing said first organic solvent, said second organic solvent, and said third organic solvent from said microdroplets to produce said microspheres.