Patent ID: 6200982
Filing Date: 2001-03-13
Classification: A61P,C07D

Abstract:
A compound which is a derivative of formula I or a salt thereof: ##STR408##wherein:R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or C.sub.2-6 alkynyloxy, and when R is not hydrogen, R is optionally independently substituted by one or more halogen atoms or hydroxy group;V is CH;W is O;X is a five-membered heteroaromatic group containing one, two, three or four heteroatoms independently selected from N, O and S providing that not more than one heteroatom is selected from O and S, the heteroaromatic group being unsubstituted or substituted with one or more groups independently selected from halogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.4-6 cycloalkenyl and CF.sub.3 ;Y is hydrogen, NR.sup.1 R.sup.2, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, Ar, O(CH.sub.2).sub.n Ar.sup.1, or C.sub.k H.sub.2k-4 Ar.sup.2 ;R.sup.1 and R.sup.2 are independently selected from C.sub.1-6 alkyl and (CH.sub.2).sub.m Ar.sup.3 ;Ar is thienyl, furyl or a six-membered heteroaromatic ring containing one or two nitrogen atoms which is unsubstituted or substituted with one or more groups independently selected from halogen and C.sub.1-6 alkyl groups and which is optionally fused to a benzene ring; or napththyl or phenyl rings which rings are unsubstituted or substituted with one or more groups independently selected from halogen, cyano, amino, nitro, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, CF.sub.3, CF.sub.3 O, C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy, C.sub.2-6 alkynyloxy, C.sub.1-6 alkylthio, C.sub.2-6 alkenylthio C.sub.2-6 alkynylthio, hydroxy, hydroxyC.sub.1-6 alkyl, NR.sup.3 R.sup.4, OC(O)NR.sup.3 R.sup.4, C.sub.1-6 alkoxyphenylC.sub.1-6 alkoxy, cyanoC.sub.1-6 alkyl, cyanoC.sub.2-6 alkenyl, cyanoC.sub.2-6 alkynyl, pyridyl, phenyl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkoxycarbonylC.sub.1-6 alkyl, C.sub.1-6 alkoxycarbonylC.sub.2-6 alkenyl, C.sub.1-6 alkoxycarbonylC.sub.2-6 alkynyl and --O(CH.sub.2).sub.p O-- and which is optionally fused to a benzene ring;Ar.sup.1, Ar.sup.2, Ar.sup.3 are independently selected from pyridyl; and phenyl which is unsubstituted or substituted with one or more groups independently selected from halogen, cyano, amino, nitro, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, CF.sub.3, C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy, C.sub.2-6 alkynyloxy, C.sub.1-6 alkylthio, C.sub.2-6 alkenylthio, C.sub.2-6 alkynylthio and --O(CH.sub.2).sub.p O--;Z is Het.sup.1 ;R.sup.3, and R.sup.4 are independently hydrogen or C.sub.1-6 alkyl;R.sup.5 and R.sup.6 are independently selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 hydroxyalkyl and (CH.sub.2).sub.m Ar.sup.3 ;Ar.sup.4 is phenyl which is unsubstituted or substituted with one or more groups independently selected from halogen, cyano, amino, nitro, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, CF.sub.3, C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy, C.sub.2-6 alkynyloxy, C.sub.1-6 alkylthio, C.sub.2-6 alkenylthio, C.sub.2-6 alkynylthio and --O(CH.sub.2).sub.p O--;Het.sup.1 is a four- or five-membered saturated ring containing a nitrogen atom optionally substituted by a hydroxy group; a six-membered saturated ring containing a nitrogen atom, and optionally a further nitrogen atom or an oxygen atom; an unsaturated five-membered heterocyclic group containing one, two, three or four heteroatoms independently selected from N, O and S providing that not more than one heteroatom is selected from O and S; or an unsaturated six-membered heterocyclic group containing one or two nitrogen atoms; each of which moieties is unsubstituted or substituted by one or more groups independently selected from halogen, cyano, amino, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, CF.sub.3, C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy, C.sub.2-6 alkynyloxy;k is 2;m and n are 1; andp is 1, or 2.