Patent ID: 6525199
Filing Date: 2003-02-25
Classification: A61P,C07C,C07D,Y02P

Abstract:
A process for producing a compound having the formula (XIIâ€²): wherein Qâ€² represents a phenyl group or a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C1 to C5 linear or branched alkoxy group, a C1 to C5 linear or branched alkyl group, and a C1 to C5 linear or branched alkyl group substituted with a halogen atom, and X represents a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, that process comprises reacting a benzophenon derivative having the formula wherein Qâ€² and X are the same as defined above, and L represents a group which can be easily exchanged with an amino group, with a piperazine derivative having the formula wherein W represents a hydrogen atom, a benzyl group, a p-methoxybenzyl group, a benzyloxycarbonyl group, a p-methoxybenzyloxycarbonyl group, a p-nitrobenzyloxycarbonyl group, a tert-butoxycarbonyl group, an ethoxycarbonyl group or an acetyl group to give a compound having the formula (XV): wherein Qâ€², W and X are the same as defined above, and the subsequent reduction and deprotection of the compound having the formula (XV) provided that when W is hydrogen then deprotection is not necessary.