Patent ID: 6407111
Filing Date: 2002-06-18
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula whereinR is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen; or R and R1 may be together â€”CH&boxH;CHâ€”CH&boxH;CHâ€”; R2 is hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano; R3 is independently from each other hydrogen, lower alkyl or form a cycloalkyl group; R4 is a cyclic tertiary amine of the group R5 is, independently from each other, hydrogen, C3-6-cycloalkyl, benzyl or lower alkyl; R6 is hydrogen, hydroxy, lower alkyl, â€”N(R5)CO-lower alkyl, hydroxy-lower alkyl, cyano, â€”CHO or a 5- or 6 membered heterocyclic group, optionally bonded via an alkylene group, X is â€”C(O)N(R5)â€” or â€”N(R5)C(O)â€”; Y is â€”C(O); Z is &boxH;Nâ€”; n is 0-4; and m is 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.