Patent ID: 7618782
Filing Date: 2009-11-17
Classification: G01N

Abstract:
1. A method for assessing skeletal muscle damage in a subject, comprising: obtaining a biological sample from a subject being assessed for skeletal muscle damage; and evaluating for the presence of one or more different myofilament protein modification products in the biological sample, at least one of said myofilament protein modification products being a chemical adduct of a myofilament protein selected from the group consisting of skeletal troponin I, skeletal troponin T and myosin light chain 1; wherein the chemical adduct of the myofilament protein is a post-translational modification of an intact myofilament protein, a post-translational modification of a degradation product of a myofilament protein or a post-translational modification of a protein-protein complex of myofilament proteins and said myofilament protein is selected from the group consisting of skeletal troponin I, skeletal troponin T and myosin light chain 1.