Patent ID: 6534515
Filing Date: 2003-03-18
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula wherein X1, X2 and X3 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 18 carbon atoms, alkenyl and alkynyl of 2 to 18 carbon atoms, alkoxy of 1 to 7 carbon atoms, â€”OH, â€”CF3, â€”NO2, â€”NH2, mono and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl; wherein R is selected from the group consisting of alkyl of 1 to 7 carbon atoms optionally substituted with a member of the group consisting of hydroxy, amino, mono and dialkylamino, 1 to 3 halogens, â€”CN, carbamoyl and acyl of an organic carboxylic acid of 1 to 6 carbon atoms, alkynyl of 2 to 7 carbon atoms and phenyl, R1 is or &boxH;C&boxH;CHâ€”R10, R10 is hydrogen or alkyl of 1 to 6 carbon atoms, one of R8 and R9 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and cyano and the other is hydrogen or alkyl of 1 to 6 carbon atoms and its pharmaceutically acceptable salts with acid or bases.