Patent ID: 6797704
Filing Date: 2004-09-28
Classification: A61K

Abstract:
A method for delivering a bioactive agent to a mammal's lymph node comprising the steps of:providing a microparticle or nanoparticle, which comprises at least one biocompatible polymer and a bioactive agent; instilling an effective amount of said microparticle or nanoparticle into a mammal's bladder such that at least a portion of the instilled microparticles or nanoparticles are localized to a lymph nodes; wherein the bioactive agent is released from the instilled microparticles or nanoparticles into the lymph node; and wherein the bioactive agent is selected from small molecule drugs, imaging agents, radioactive therapeutics, dyes, proteins, DNA, RNA and combinations thereof, and wherein the biocompatible polymer is a homopolymer or copolymer comprising one or more monomer repeat units selected from lactic acid, glycolic acid, lactide, lactone, poly(ethylene oxide), and poly(propylene oxide).