Patent ID: 6022978
Filing Date: 2000-02-08
Classification: A61P,C07D,Y02P

Abstract:
A compound of the formula ##STR5## wherein D is hydrogen or (.sub.1 -C.sub.10) straight or branched alkyl; Y is hydrogen or methyl;R.sup.1 is hydrogen, halo, --S--(C.sub.1 -C.sub.6)alkyl, or (C.sub.1 -C.sub.10) straight or branched alkyl, wherein said alkyl may optionally be substituted with one or more substituents selected from chloro, fluoro, bromo, iodo, --S(C.sub.1 -C.sub.4)alkyl, amino, --NH(C.sub.1 -C.sub.4)alkyl and --N[(C.sub.1 -C.sub.4)alkyl].sub.2 ;R.sup.2, R.sup.3 and R.sup.4 are selected, independently, from fluoro, chloro, (C.sub.1 -C.sub.6)alkyl and (C.sub.1 -C.sub.6)alkoxy; or two of R.sup.2, R.sup.3, and R.sup.4 are hydrogen and the other is selected from hydroxy, iodo, bromo, formyl, cyano, nitro, trifluoromethyl, amino, (C.sub.1 -C.sub.6)alkyl-O--(C.sub.1 -C.sub.6)alkyl, --NHCH.sub.3, --NH(CH.sub.3).sub.2, --COCH, --COO(C.sub.1 -C.sub.4)alkyl, --CO(C.sub.1 -C.sub.4)alkyl, --SO.sub.2 --NH(C.sub.1 -C.sub.4)alkyl, SO.sub.2 --N[(C.sub.1 -C.sub.4)alkyl].sub.2, --SO.sub.2 NH.sub.2, --NHSO.sub.2 --(C.sub.1 -C.sub.4)alkyl, --S(C.sub.1 -C.sub.6)alkyl and --SO.sub.2 --(C.sub.1 -C.sub.6)alkyl, and wherein the (C.sub.1 -C.sub.4) and (C.sub.1 -C.sub.6)alkyl moieties in the foregoing R.sup.2, R.sup.3 and R.sup.4 groups may optionally be substituted with one or two fluoro groups or with one substituent selected from hydroxy, amino, methylamino, dimethylamino and acetyl;or a pharmaceutically acceptable salt of said compound.