Patent ID: 6214876
Filing Date: 2001-04-10
Classification: A61P,C07C,C07F

Abstract:
An indene-1-acetamide compound or a pharmaceutically acceptable salt, solvate or prodrug derivative thereof; wherein said compound is represented by the formula (I); ##STR24##wherein;X is oxygen or sulfur;each R.sub.1 is independently hydrogen, C.sub.1 -C.sub.3 alkyl, or halo;R.sub.3 is selected from groups (a), (b) and (c) where;(a) is C.sub.7 -C.sub.20 alkyl, C.sub.7 -C.sub.20 alkenyl, C.sub.7 -C.sub.20 alkynyl, carbocyclic radical, or heterocyclic radical, or(b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or(c) is the group --(L)--R.sub.80 ; where, --(L)-- is a divalent linking group of 1 to 12 atoms and where R.sub.80 is a group selected from (a) or (b);R.sub.2 is hydrogen, halo, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.4 cycloalkyl, C.sub.3 -C.sub.4 cycloalkenyl, --O--(C.sub.1 -C.sub.2 alkyl), --S--(C.sub.1 -C.sub.2 alkyl), or a non-interfering substituent having a total of 1 to 3 atoms other than hydrogen;R.sub.6 and R.sub.7 are independently selected from hydrogen, a non-interfering substituent, or the group, --(L.sub.a)-- (acidic group); wherein --(L.sub.a)--, is an acid linker having an acid linker length of 1 to 10; provided, that at least one of R.sub.6 and R.sub.7 must be the group, --(L.sub.a)-- (acidic group); andR.sub.4 and R.sub.5 are each independently selected from hydrogen, non-interfering substituent, carbocyclic radical, carbocyclic radical substituted with non-interfering substituents, heterocyclic radical, and heterocyclic radical substituted with non-interfering substituents.