Patent ID: 6770636
Filing Date: 2004-08-03
Classification: C07C,C07D

Abstract:
A compound of formula 1wherein:R1 is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy; R2, R3, and R4 independently of one another are hydrogen, C1-C8-alkyl, hydroxy, NO2, CN, C1-C8-alkoxyl, CF3, or halogen; R5 and R6 independently of one another are hydrogen or a group consisting of C1-C8-alkyl, C2-C8-alkenyl, C3-C8-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkylene, C5-C8-cyclokenyl, C5-C8-cycloalkenyl-C1-C6-alkylene, C6-C10-aryl, and C6-C10-aryl-C1-C6-alkylene, each optionally substituted by a group consisting of C1-C6-alkyl, C2-C6-alkenyl, halogen, C1-C6-alkyloxy, â€”NH2, â€”NH(C1-C4-alkyl), â€”N(C1-C4-alkyl)2, hydroxy, &boxH;O, â€”COOH, â€”COâ€”OC1-C4-alkyl, â€”CONH2, â€”CONH(C1-C4-alkyl), â€”CON(C1-C4-alkyl)2, and CF3, or R5 and R6 together with the nitrogen atom are a saturated or unsaturated 5-, 6-, 7-, or 8-membered heterocyclic group optionally containing one or two further heteroatoms consisting of sulfur, oxygen, and nitrogen, and optionally mono-, di-, or trisubstituted by a group consisting of C1-C4-alkyl, hydroxy, &boxH;O, â€”COOH, â€”COâ€”OC1-C4-alkyl, â€”CONH2, â€”CONH(C1-C4-alkyl), â€”CON(C1-C4-alkyl)2, halogen, and benzyl; X is oxygen, â€”NHâ€”, â€”N(CHO)â€”, â€”N(COâ€”C1-C6-alkyl), â€”N(C1-C6-alkyl), or â€”N(C3-C6-cycloalkyl-C1-C4-alkylene); and A is a group consisting of C1-C6-alkylene, C2-C6-alkenylene, and C3-C6-alkynylene, or a free base or pharmacologically acceptable acid addition salt thereof.