Patent ID: 6015543
Filing Date: 2000-01-18
Classification: A61K,A61P,C07B,C07D

Abstract:
A method for diagnosing a mammal for the presence of a mammalian tumor which comprises administering to a mammal a diagnostic imaging effective amount of a compound of the formula: ##STR18## wherein: X is a radionuclide;Z is .dbd.O;each R.sub.1 is independently H, halo, lower alkyl, lower alkoxy;R.sub.a and R.sub.b are independently H, halo, lower alkyl, lower alkoxy;R.sub.2 is an N-linked 5 to 7 membered monocyclic nitrogen containing heterocyclic ring which has zero or up to two oxygen ring atoms, which heterocyclic ring is unsubstituted or substituted with at least one alkyl or substituted or unsubstituted arylalkyl substituent, said alkyl containing 1-6 carbon atoms, said nitrogen containing heterocyclic ring having up to seven ring atoms including 2-6 ring carbon atoms and 1-3 ring heteroatoms of which at least one is nitrogen, said arylalkyl unsubstituted or substituted with a halogen, alkoxy or alkyl group;each R.sub.3 is independently hydrogen or lower alkyl;j and y are independently an integer from 0 to 6;q is an integer from 0 to 2and detecting binding of said compound to a tumor in said mammal.