Patent ID: 6171232
Filing Date: 2001-01-09
Classification: A61L,Y10S

Abstract:
A method of providing a medical device having a working surface for deployment within a vascular system, which comprises:attaching a thiol group sulfur agent to a working surface of a medical device, said thiol group sulfur agent including a protected sulfur, said thiol group sulfur agent is selected from the group consisting of disulfides, thioethers, thioesters and semithioacetals;deprotecting said protected sulfur with a removal agent while attached onto the working surface of the medical device to provide a treated working surface, said treated working surface having deprotected sulfhydryl groups;loading a nitric oxide carrier onto said treated working surface having deprotected sulfhydryl groups; andinteracting the nitric oxide carrier and sulfhydryl groups with each other to enhance the efficacy of the nitric oxide carrier.