Patent ID: 6794393
Filing Date: 2004-09-21
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula I or a pharmaceutically acceptable salt or stereoisomer thereof, wherein W1 is S, O, or Nâ€”R; V1 is N or C; W2 is N or C; V2 is S, O, or Nâ€”R; a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; s is 1 or 2; t is 1, 2, or 3; R is H or C1-C6 alkyl; R1 and R5 are independently selected from: 1) H, 2) (C&boxH;O)aObC1-C10 alkyl, 3) (C&boxH;O)aObaryl, 4) (C&boxH;O)aObC2-C10 alkenyl, 5) (C&boxH;O)aObC2-C10 alkynyl, 6) CO2H, 7) halo, 8) OH, 9) ObC1-C6 perfluoroalkyl, 10) (C&boxH;O)aNR7R8, 11) CN, 12) (C&boxH;O)aObC3-C8 cycloalkyl, and 13) (C&boxH;O)aObheterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R6; R2 and R3 are independently selected from: 1) H, 2) (C&boxH;O)OaC1-C6 alkyl, 3) (C&boxH;O)Oaaryl, 4) C1-C6 alkyl, 5) SO2Ra, and 6) aryl; R4 is selected from: 1) (C&boxH;O)aObC1-C10 alkyl, 2) (C&boxH;O)aObaryl, 3) (C&boxH;O)aObC2-C10 alkenyl, 4) (C&boxH;O)aObC2-C10 alkynyl, 5) CO2H, 6) halo, 7) OH, 8) ObC1-C6 perfluoroalkyl, 9) (C&boxH;O)aNR7R8, 10) CN, 11) (C&boxH;O)aObC3-C8 cycloalkyl, and 12) (C&boxH;O)aObheterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R6; R6 is: 1) (C&boxH;O)aObC1-C10 alkyl, 2) (C&boxH;O)aObaryl, 3) C2-C10 alkenyl, 4) C2-C10 alkynyl, 5) (C&boxH;O)aObheterocyclyl, 6) CO2H, 7) halo, 8) CN, 9) OH, 10) ObC1-C6 perfluoroalkyl, or 11) Oa(C&boxH;O)bNR7R8, 12) oxo, 13) CHO, 14) (N&boxH;O)R7R8, and 15) (C&boxH;O)aObC3-C8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selcted from R6a; R6a is selected from: 1) (C&boxH;O)rOs(C1-C10)alkyl, wherein r and s are independently 0 or 1, 2) Or(C1-C3)perfluoroalkyl, wherein r is 0 or 1, 3) (C0-C6)alkylene-S(O)mRa, wherein m is 0, 1, or 2, 4) oxo, 5) OH, 6) halo, 7) CN, 8) (C2-C10)alkenyl, 9) (C2-C10)alkynyl, 10) (C3-C6)cycloalkyl, 11) (C0-C6)alkylene-aryl, 12) (C0-C6)alkylene-heterocyclyl, 13) (C0-C6)alkylene-N(Rb)2, 14) C(O)Ra, 15) (C0-C6)alkylene-CO2Ra, 16) C(O)H, and 17) (C0-C6)alkylene-CO2H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from Rb, OH, (C1-C6)alkoxy, halogen, CO2H, CN, O(C&boxH;O)C1-C6 alkyl, oxo, and N(Rb)2; R7 and R8 are independently selected from: 1) H, 2) (C&boxH;O)ObC1-C10 alkyl, 3) (C&boxH;O)ObC3-C8 cycloalkyl, 4) (C&boxH;O)Obaryl, 5) (C&boxH;O)Obheterocyclyl, 6) C1-C10 alkyl, 7) aryl, 8) C2-C10 alkenyl, 9) C2-C10 alkynyl, 10) heterocyclyl, 11) C3-C8 cycloalkyl, 12) SO2Ra, 13) (C&boxH;O)NRb2, said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R6a, or R7 and R8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 5-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocylcic or bicyclic heterocycle optionally substituted with one or more substituents selected from R6a; Ra is (C1-C6)alkyl, (C3-C6)cycloalkyl, aryl, or heterocyclyl; Rb is H, (C1-C6)alkyl, aryl, heterocyclyl, (C3-C6)cycloalkyl, (C&boxH;O)OC1-C6 alkyl, (C&boxH;O)C1-C6 alkyl or S(O)2Ra; and the term â€œheterocyclylâ€  is intended to mean a 5- to 10-membered aromatic or nonaromatic heterocycle containing from 1 to 4 heteroatoms selected from the group consisting of O, N and S and including bicyclic groups.