Patent ID: 8039480
Filing Date: 2011-10-18
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula Ia, where the  the radical is a spiro compound, in which the sub-rings  are combined to form a 6-azaspiro[2.5]octane or 5-azaspiro[2.5]octane ring which is unsubstituted or independently, according to the ring size, mono-, di-, tri-, or tetrasubstituted by R4, where R4 is —NO R8 is halogen, carbamimidoyl, —NO R9 is halogen, —NO R10 and R20 are the same or different and are each independently a hydrogen atom, —(C R11 and R19 are the same or different and are each independently a hydrogen atom or —(C R12 is —(C R21 and R22 are the same or different and are each independently a hydrogen atom, —(C R21 and R22, together with the nitrogen atom to which they are bonded, form a four- to eight-membered monocyclic heterocyclic ring which, as well as the nitrogen atom, additionally, according to the ring size, may contain one or two identical or different heteroatoms selected from the group of oxygen, nitrogen and sulfur and in which the heterocycle is unsubstituted or mono-, di- or trisubstituted independently by R8; R23 is a hydrogen atom, —OH or —O—(C X is a covalent bond, —N(R7)- or —O—, where R7 is a hydrogen atom, —(C Y is —C(O)—, —C(S)—or —S(O p is the integer 1 or 2; R27 is a hydrogen atom, —(C R26 is a hydrogen atom, —(C R24 and R25 are the same or different and are each independently a hydrogen atom, —(C R24 and R25, together with the carbon atom to which they are bonded, form a three- to six-membered cycloalkyl ring which is unsubstituted or mono-, di- or trisubstituted independently by R10 or fluorine; or R24 and R25, together with the carbon atom to which they are bonded, form a three- to six-membered heterocycloalkyl radical which is unsubstituted or mono-, di- or trisubstituted independently by R10 or fluorine; or a physiologically tolerated salt thereof.