Patent ID: 6180646
Filing Date: 2001-01-30
Classification: A61P,C07D

Abstract:
A pharmaceutical composition comprising a compound represented by the formula: ##STR143##including a pharmaceutically acceptable salt, prodrug or ester thereof, wherein:R' represents radicals as defined for R.sup.3 or aminoalkyl radicals wherein said amino group may be mono- or disubstituted with substituents selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl and heterocycloalkyl alkyl radicals;t represents either 0 or 1;R.sup.1 represents hydrogen, --CH.sub.2 SO.sub.2 NH.sub.2, --CO.sub.2 CH.sub.3, --CH.sub.2 CO.sub.2 CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --CH.sub.2 CONHCH.sub.3, --CH.sub.2 CHCON(CH.sub.3).sub.2, alkyl, alkenyl, alkynyl or cycloalkyl radicals or amino acid side chains selected from the group consisting of asparagine, S-methyl cysteine and the corresponding sulfoximide and sulfone derivatives thereof, glycine, leucine, isoleucine, allo-isoleucine, tert-leucine, alanine, phenylalanine, ornithine, histidine, norluecine, glutamine, valine, threonine, allo-threonine, serine, aspartic acid and betacyano alanine side chains;R.sup.2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl or aralkyl radicals, which radicals are optionally substituted with a substituent selected from the group consisting of --NO.sub.2, --OR.sup.9, --SR.sup.9, and halogen radicals, wherein R.sup.9 represents hydrogen or alkyl radicals;R.sup.3 represents alkyl, hydrogen, alkenyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, or heteroaralkyl radicals;Y"" represents O, S or NR.sup.3 ;R.sup.4 and R.sup.5 together with the nitrogen atom to which they are bonded represent a 6-, 7-, or 8-membered N-heterocyclic moiety;R.sup.6 represents hydrogen or alkyl radicals; andR.sup.20 and R.sup.21 represent radicals as defined for R.sup.1 ;and a pharmaceutically acceptable carrier.