Patent ID: 8193353
Filing Date: 2012-06-05
Classification: A61P,C07D

Abstract:
1. A method for the pharmacological treatment of neuropathic and inflammatory pain, comprising administering, to a subject in need thereof, an effective amount of a compound of Formula (I): wherein: X is a nitrogen atom; W is independently selected from an aryl group or an heteroaryl group of Formula II: when W is an aryl group, it is an unsubstituted phenyl of or phenyl substituted with one or more substituents independently selected from halogen (—F, —Cl, —Br), trifluoromethyl (—CF when W is an heteroaryl group of Formula II, it is a benzocondensed-5 or -6 membered heterocycle, wherein: Z and Y are independently selected from: an oxygen atom (—O—), a sulphur atom (—S—), or the groups: —SO Q is independently selected from the groups: —CHR provided that the combination of Y, Z, Q groups give rise to: 1,3-benzodioxole, 1,3-benzodithiol, benzofuran, 2,3-dihydrobenzofuran, benzothiophene, 2,3-dihydrobenzothiophene, 2,3-di-hydrobenzothiophene S,S-dioxide, indole, 2,3-dihydroindole, benzimidazole, benzoxazole, benzothiazole, 2H-3,4-dihydrobenzopyran, 2H-3,4-dihydrobenzothiopyran, 2H-3,4-dihydrobenzothiopyran S,S-dioxide, 2,3-dihydro-[1,4]-benzodioxine (1,4-benzodioxan), 2,3-dihydro-[1,4]-benzothiazine, 2,3-dihydro-[1,4]-benzothiazine S,S-dioxide, [2,3-dihydro-[1,4]-benzoxazine; R1 is independently selected from hydrogen (—H) or C R R