Patent ID: 6399635
Filing Date: 2002-06-04
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I) whereinm is 0; n is 2; R1 is selected from hydrogen; a branched or straight C1-C6 alkyl; C3-C8 cycloalkyl; C4-C8 (alkyl-cycloalkyl) wherein alkyl is C1-C2 alkyl and cycloalkyl is C3-C6 cycloalkyl; benzyl; where G is a hydroaromatic or a heteroaromatic group having 5 or 6 atoms, and where the heteroatoms are selected from O, S and N; and and wherein n=0 or 1; C6-C10 aryl; or heteroaryl having from 5 to 10 atoms selected from any of C, S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, (CH2)pCF3, halogen, CONR5R4, COOR5, COR5, (CH2)pNR5R4, (CH2)pCH3(CH2)pSOR5R4, (CH2)pSO2R5, and (CH2)pSO2NR5, wherein R4 and R5 is each and independently as defined for R1 above and p is 0, 1 or 2; (C1-C2 alkyl)-(C6-C10 aryl); or (C1-C2 alkyl)heteroaryl, the heteroaryl moieties having from 5 to 10 atoms selected from any of C, S, N and O, and where the aryl or heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH3, CONR5R4, COOR5, COR5, (CH2)qNR5R4, (CH2)qCH3(CH2)qSOR5R4, (CH2)qSO2R5, (CH2)qSO2NR5, and (CH2)qOR4, wherein R4 and R5 is each and independently as defined for R1 above and q is 0, 1 or 2; A is â€ƒwherein R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 is each and independently as defined for R1 above and wherein the phenyl ring of each A substituent may be optionally and independently substituted by 1 or 2 substituents Z1 and Z2 which are each and independently selected from hydrogen, CH3, (CH2)rCF3, halogen, CONR2R3, CO2R2, COR2, (CH2)rNR2R3, (CH2)rCH3(CH2)rSOR2, (CH2)rSO2R2, and (CH2)rSO2NR2R3, wherein R2 and R3 is each and independently as defined for R1 above and wherein r is 0, 1 or 2; X is O, S or NR19 where R19 is as defined for R1, B is a substituted or unsubstituted aromatic, heteroaromatic, hydroaromatic or heterohydroaromatic moiety having from 5 to 10 atoms selected from any of C, S, N and O, optionally and independently substituted by 1 or 2 substituents independently selected from hydrogen, CH3, (CH2)tCF3, halogen, (CH2)tCONR5R4, (CH2)tNR5R4, (CH2)tCOR5, (CH2)tCOOR5, OR5, (CH2)tSOR5, (CH2)tSO2R5, and (CH2)tSO2NR5R4, wherein R4 and R5 is each and independently as defined for R1; and t is 0, 1, 2 or 3; or the pharmaceutically acceptable salt, isomer, hydrate, isoform or prodrug thereof.