Patent ID: 6635644
Filing Date: 2003-10-21
Classification: A61P,C07D

Abstract:
A compound having the formula: or tautomers thereof or pharmaceutically acceptable salts thereof; wherein:HET is a 5-7-membered heterocycle with 1 to 4 ring N, S or O atoms, which heterocycle is substituted with 1 to 3 C1-C4 branched or straight chain alkyl groups; wherein HET is optionally substituted with halo, cyano, N(Râ€²)2, ORâ€²CO2Râ€², CON(Râ€²)2, or SO2N(R2)2; X is O or NRâ€²; n is 1 to 3; each Râ€² is independently selected from hydrogen, (C1-C3)-alkyl, (C2-C3)-alkenyl or alkynyl, phenyl or phenyl substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; or a 5-6 membered heterocyclic ring system optionally substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl, or ethyl; R1 is selected from hydrogen, (C1-C3)-alkyl, OH, or Oâ€”(C1-C3)-alkyl; R2 is selected from hydrogen, (C1-C3)-alkyl, or (C2-C3)-alkenyl; each optionally substituted with â€”N(Râ€²)2, â€”ORâ€², SRâ€², â€”C(O)â€”N(Râ€²)2, â€”S(O2)â€”N(Râ€²)2, â€”C(O)â€”ORâ€², or R3; and R3 is selected from 5-6 membered aromatic carbocyclic or heterocyclic ring systems.