Patent ID: 6660731
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound of formula IV: or a pharmaceutically acceptable salt thereof, wherein:Ring D is selected from a phenyl, pyridinyl, piperidinyl, piperazinyl, pyrrolidinyl, thienyl, azepanyl, morpholinyl, 1,2,3,4-tetrahydroisoquinolinyl, 1,2,3,4-tetrahydroquinolinyl, 2,3-dihydro-1H-isoindolyl, 2.3-dihydro-1H-indolyl, isoquinolinyl, quinolinyl, or naphthyl ring, wherein Ring D is independently substituted at any substitutable ring carbon by oxo or â€”R5, and at any substitutable ring nitrogen by â€”R4, provided that when Ring D is a six-membered aryl or heteroaryl ring, â€”R5 is hydrogen at each ortho carbon position of Ring D; Rx and Ry are independently selected from T-R3; T is a valence bond or a C1-4 alkylidene chain; R2 and R2 are independently selected from â€”R, -T-W-R6; R3 is selected from â€”R, -halo, &boxH;O, â€”OR, â€”C(&boxH;O)R, â€”CO2R, â€”COCOR, â€”COCH2COR, â€”NO2, â€”CN, â€”S(O)R, â€”S(O)2R, â€”SR, â€”N(R4)2, -â€”ON(R4)2, â€”SO2N(R4)2, -OC(&boxH;O)R, N(R4)COR, â€”N(R4)CO2(optionally substituted C1-6 aliphatic), â€”N(R4)N(R4)2, â€”C&boxH;NN(R4)2, â€”C&boxH;Nâ€”OR, â€”N(R4)CON(R4)2. â€”N(R4)SO2N(R4)2, â€”N(R4)SO2R, or each R is independently selected from hydrogen or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; each R4 is independently selected from â€”R7, â€”COR7, â€”CO2(optionally substituted C1-6 aliphatic), â€”CON(R7)2, or â€”SO2R7, or two on the same nitrogen are taken together to form a 5-8 membered heterocyclyl or heteroaryl ring; each R5 independently selected from â€”R, halo, â€”OR, â€”C(O)R, â€”CO2R, â€”COCOR, â€”NO2, â€”CN, â€”S(O)R, â€”SO2R, â€”SR, â€”N(R4)2, â€”CON(R4)2, â€”SO2N(R4)2, â€”OC(&boxH;O)R, â€”N(R4)COR, â€”N(R4)CO2(optionally substituted C1-6 aliphatic), â€”N(R4)N(R4)2, â€”C&boxH;NN(R4)2, â€”C&boxH;Nâ€”OR, â€”N(R4)CON(R5)2, â€”N(R4)SO2N(R4)2, â€”N(R4)SO2R, or â€”OC(&boxH;0)N(R4)2; V is â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2N(R6)SO2, â€”SO2N(R6)â€”, â€”N(R6)â€”, â€”COâ€”, â€”CO2, â€”N(R6)COâ€”, â€”N(R6)C(O)Oâ€”, â€”N(R6)CON(R6)â€”, â€”N(R6)SO2N(R6)â€”, â€”N(R5)N(R6)â€”, â€”C(O)N(R6)â€”, â€”OC(O)N(R6)â€”, â€”C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)2SOâ€”, â€”C(R6)2SO2â€”, â€”C(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”, â€”C(R6)N(R6)C(O)â€”, â€”C(R6)2N(R6)C(O)Oâ€”. â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, or â€”C(R6)2N(R6)CON(R6)â€”; W is C(R6)2Oâ€”, â€”C(R6)2Sâ€”, â€”C(R6)2SO2, â€”(R6)2SO2N(R6)â€”, â€”C(R6)2N(R6)â€”â€”COâ€”, â€”CO2â€”, â€”(R6)OC(O)â€”, â€”C(R6)OC(O)N(R6)â€”, â€”C(R6)2N(R6)COâ€”, â€”C(R6)2N(R6)C(O)Oâ€”, â€”C(R6)&boxH;NN(R6)â€”, â€”C(R6)&boxH;Nâ€”Oâ€”, â€”C(R6)2N(R6)N(R6)â€”, â€”C(R6)2N(R6)SO2N(R6)â€”, â€”C(R6)2N(R6)CON(R6)â€”, or â€”CON(R6)â€”; each R6 is independently selected from hydrogen or an optionally substituted C1-4 aliphatic group, or two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to form a 5-6 membered heterocyclyl or heteroaryl ring; and each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group, or two R7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclyl ring or heteroaryl.