Patent ID: 7851627
Filing Date: 2010-12-14
Classification: C07D

Abstract:
1. A process for the preparation of 1-[(4-chlorophenyl)-methylphenyl]-piperazine of the Formula (I) enantiomers and acid addition salts thereof, which comprises reacting the racemic or an optically active form of 1-[(4-chlorophenyl)-phenylmethyl]-4-benzyl-piperazine of the Formula (III) with 2,2,2-trichloroethylchloroformate of the Formula (X) and converting the thus obtained 1-[(4-chlorophenyl)-phenylmethyl]-4-(2,2,2-trichloroethoxy-carbonyl)-piperazine of the Formula (IV) into 1-[(4-chlorophenyl)-methylphenyl]-piperazine of the Formula (I).