Patent ID: 6498039
Filing Date: 2002-12-24
Classification: C12N,C12Q,G01N,H01J,Y10T

Abstract:
A sample presentation apparatus comprising:(a) a mass spectrometry sample presentation apparatus having a mass spectrometry sample presentation surface, wherein the surface is a metal surface; (b) a complex immobilized on the sample presentation surface, the complex comprising (i) a tethering molecule attached to the sample presentation surface, and (ii) at least one reactive molecule attached to the tethering molecule, wherein the at least one reactive molecule is bound to an impurity removed from a sample solution containing a biomolecule for analysis and the impurity thereby providing a purified sample solution containing the biomolecule for analysis, wherein the biomolecule is selected from the group consisting of polypeptides, DNA, carbohydrates, RNA, and combinations thereof; and (c) a mixture of the purified sample solution containing the biomolecule for analysis and MALDI matrix material on the sample presentation surface.