Patent ID: 6436975
Filing Date: 2002-08-20
Classification: A61K,A61P,Y10S

Abstract:
Pharmaceutical compositions comprising as components the following:component a): â€ƒwherein: RI3, RI4 equal to or different from each other, are respectively free valence, hydrogen, â€”N&boxH;C(NH2)2, â€”CH2â€”N(CH3)2; Y&boxH;S, Nâ€”RI6, CRI7RI8; X&boxH;O, S, Nâ€”RI1; RI2&boxH;H, CH3; n=0, 1; Z&boxH;Nâ€”CN, Nâ€”SO2NH2, CHâ€”NO2 or â€ƒRI5&boxH;H, â€”NHâ€”CH3, NH2; RI6, RI7, RI8, RI1, equal to or different from each other, are hydrogen, free valence; component b): one or more organic compounds containing the â€”ONO2 group, or one or more inorganic compounds containing the â€”NO group, or mixtures thereof, said compounds being characterized in that they are NO nitric oxide donors, i.e. when they are brought into contact in vitro with cells of the vassal endothelium, platelets, and after incubation of 5 minutes at a temperature of 37Â° C., are capable to release NO and to activate the cGMP synthesis (Guanosine cyclic 3â€²,5â€²-(hydrogen phosphate)).