Patent ID: 6582471
Filing Date: 2003-06-24
Classification: A61B,A61F,A61K,A61L,A61P,B82Y,Y10S

Abstract:
Composition for inducing in vivo cartilage repair comprising an osteoinductive and/or chondroinductive protein mixture derived from bone, cartilage, tendon, meniscus or ligament or a sythetic mimic of such a mixture encapsulated in nanospheres, wherein the nanospheres are polymer particles having a size of less than 1000 nm and an in vitro analytically determined profile of release into saline solution with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of 0.1 and 1% per day during 40 to 70 days and wherein the nanospheres are loaded with an amount of the mixture constituting between 0.001 and 17% of the total weight of the loaded nanospheres.