Patent ID: 7874975
Filing Date: 2011-01-25
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating vulnerable plaque in a patient, said method comprising: diagnosing a patient for vulnerable plaque; identifying a body site associated with the vulnerable plaque; and administering a therapeutic composition to the patient, the therapeutic composition comprising a conversion electron emitting source (CEES) and a substance capable of binding to a marker of inflammation present in the vulnerable plaque; said therapeutic composition localizing in said identified body site and emitting a therapeutically effective dosage of conversion electrons to the body site, wherein the localized therapeutic composition emits the therapeutically effective dosage of conversion electrons to the identified body site and the therapeutically effective dosage is in the range from 0.05 μCi to 2 mCi at the identified body site and is sufficient to inhibit the rupture of vulnerable plaque, or treat vulnerable plaque which has ruptured; and wherein the conversion electron emitting source (CEES) comprises tin-117m and the marker of inflammation comprises annexin V.