Patent ID: 7989395
Filing Date: 2011-08-02
Classification: C07H,C12N

Abstract:
1. A method for identifying one or more compounds which bind to a biological target, said method comprising: (A) synthesizing a library of compounds, wherein the compounds comprise a functional moiety comprising two or more building blocks which is operatively linked to an encoding oligonucleotide which identifies the structure of the functional moiety by: (B) contacting the biological target with the library of compounds, or a portion thereof, under conditions suitable for at least one member of the library of compounds to bind to the target; (C) removing library members that do not bind to the target; (D) sequencing the encoding oligonucleotides of the at least one member of the library of compounds which binds to the target, and (E) using the sequences determined in step (D) to determine the structure of the functional moieties of the members of the library of compounds which bind to the biological target, thereby identifying one or more compounds which bind to the biological target.