Patent ID: 8168649
Filing Date: 2012-05-01
Classification: A61P,C07C,C07D

Abstract:
1. A compound represented by formula I: or a pharmaceutically acceptable salt thereof is disclosed wherein: X represents CH R said Aryl and HAR being further optionally substituted with 1-3 groups, 1-3 of which are halo, and 0-1 of which are selected from the group consisting of: OH, NH a and b are each integers 1 or 2, such that the sum of a and b is 3; ring A is selected from the group consisting of: phenyl; naphthyl; HAR which represents a member selected from the group consisting of: pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, pyridyl, oxazolyl, oxadiazolyl, thiadiazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, furanyl, triazinyl, thienyl, pyrimidyl, pyridazinyl, pyrazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, benzopyrazolyl, benzotriazolyl, furo(2,3-b)pyridyl, benzoxazinyl, tetrahydrohydroquinolinyl, tetrahydroisoquinolinyl, quinolyl, isoquinolyl, indolyl, dihydroindolyl, quinoxalinyl, quinazolinyl, naphthyridinyl, pteridinyl, 2,3-dihydrofuro(2,3-b)pyridyl indolinyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, or a member selected from the group consisting of: each R n represents an integer of from 1 to 5; each R R or —C(O)NHSO 2 R e wherein R e represents C 1-4 alkyl or phenyl, said C 1-4 alkyl and phenyl each being optionally substituted with 1-3 groups, 1-3 of which are selected from halo and C 1-3 alkyl, and 1-2 of which are selected from the group consisting of: OC 1-3 alkyl, haloC 1-3 alkyl, haloC 1-3 alkoxy, OH, NH 2 and NHC 1-3 alkyl; and each R a) halo, OH, f) phenyl or a 5-6 membered heteroaryl, said heteroaryl is pyridinyl, pyrazolyl, triazolyl, or dihydrobenzofuranyl, attached at any available ring atom and each being optionally substituted with 1-3 groups, 1-3 of which are selected from halo, OH; NH