Patent ID: 6376667
Filing Date: 2002-04-23
Classification: C07D

Abstract:
A method for preparing a compound represented the formula (Formula I): in whichthe dashed line represents an optional bond; R1 and R2 are each, independently, hydrogen, alkyl, or aryl; R3 and R4 are each, independently, hydrogen, halogen, alkyl, or aryl; or R3 and R4 are joined to form a carbocyclic or heterocyclic ring having from 5 to 7 atoms in the ring moiety, wherein the atoms are selected from carbon, nitrogen, oxygen, or sulfur; the method comprising: reacting a compound represented by the formula (Formula II): â€ƒin which R1, R2, R3, and R4 are as described above, and PS is a polymer support, by; contacting the compound represented by Formula II with a solid inorganic base in an amount sufficient to promote ring closure and cleavage from the polymer support under conditions such that the compound of Formula I is prepared.