Patent ID: 6358523
Filing Date: 2002-03-19
Classification: A61K,B82Y

Abstract:
A method for regulating the structure of a macromolecule-lipid complex comprising:a. selecting a charged macromolecule; b. selecting a charged lipid combination; the charge of the lipid combination being opposite of the charge of the macromolecule; c. determining an amount of the macromolecule and the lipid combination sufficient to regulate the structure of the complex by: i. selecting a characteristic or multiple characteristics of the complex from the group of characteristics consisting of macromolecule interaxial distance (dM), membrane thickness of the lipid combination (&dgr;m), and the ratio (L/D) between the weight of the lipid combination (L) and the weight of the macromolecule (D); and ii. modulating any of the characteristics not selected in (i) so as to achieve the selected characteristic thereby determining the amount of the macromolecule and lipid combination sufficient to regulate the structure of the complex; and d. combining the macromolecule with the lipid combination in the amount so determined thereby resulting in the complex having the desired structure.