Patent ID: 6013652
Filing Date: 2000-01-11
Classification: C07D

Abstract:
A compound selected from the group consisting of:(a) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-t-(butoxycarbonyl)(methylamino))buty l)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(b) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(c) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(benzoyl)(methylamino))butyl)-1-meth anesulfonyl-spiro(indoline-3,4'-piperidine);(d) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-bistrifluoromethylbenzoyl)(meth ylamino))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(e) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-methylbenzoyl)(methylamino))butyl )-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(f) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-chlorobenzoyl)(methylamino))butyl )-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(g) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-trifluoromethylbenzoyl)(methylami no))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(h) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dichlorobenzoyl)(methylamino))b utyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(i) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-trifluoromethylphenylacetyl)(meth ylamino))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(j) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-isopropyloxyphenylacetyl)(methyla mino))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(k) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(benzenesulfonyl)(methylamino))butyl )-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(l) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-benzyoxycarbonyl-spiro(indoline-3,4'-piperidine);(m) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-spiro(indoline-3,4'-piperidine);(n) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-propionyl-spiro(indoline-3,4'-piperidine);(o) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-formyl-spiro(indoline-3,4'-piperidine);(p) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-t-butylcarbonyl-spiro(indoline-3,4'-piperidine);(q) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-methylaminocarbonyl-spiro(indoline-3,4'-piperidine);(r) 1'(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))bu tyl)-1-ethoxycarbonyl-spiro(indoline-3,4'-piperidine);(s) 1'(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))bu tyl)-1-ethanesulfonyl-spiro(indoline-3,4'-piperidine);(t) 1'(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))bu tyl)-1-1-propanesulfonyl-spiro(indoline-3,4'-piperidine);(u) 1'(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))bu tyl)-1'-methyl-1-methanesulfonyl-spiro-indoline-3,4'-piperidinium iodide;(v) 1'-(3-(S)-(3,4-dichlorophenyl)-4-(N-(R or S)-(3-methylbenzoyl)(methylamino))pentyl)-1-methanesulfonyl-spiro(indoline -3,4'-piperidine);(w) 1'-(3-(S)-(3,4-dichlorophenyl)-4-(N-(R or S)-(3,5-bis(trifluoromethyl)benzoyl)(methylamino))pentyl)-1-methanesulfony l-spiro(indoline-3,4'-piperidine);(x) 1'-(3-(S)-(3,4-dichlorophenyl)-4-(N-(R or S)-(3,5-dimethylbenzoyl)(methylamino))pentyl)-1-methanesulfonyl-spiro-(ind oline-3,4'-piperidine);(y) 1'-(3-(S)-(3,4-dichlorophenyl)-4-(N-(R or S)-(3,5-dichlorobenzoyl)(methylamino))pentyl)-1-methanesulfonyl-spiro-(ind oline-3,4'-piperidine);(z) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-difluorobenzoyl)(methylamino))b utyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(aa) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-fluoro-5-(trifluoromethyl)benzoyl )(methylamino))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(ab) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(1-naphthoyl)(methylamino))butyl)-1- methanesulfonyl-spiro(indoline-3,4'-piperidine);(ac) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(2-chlorophenylsulfonyl)-(methylamin o))butyl)-1-methylsulfonyl-spiro(indoline-3,4'-piperidine);(ad) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-chlorophenylsulfonyl)-(methylamin o))butyl)-1-methylsulfonyl-spiro(indoline-3,4'-piperidine);(ae) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(4-chlorophenylsulfonyl)-(methylamin o))butyl)-1-methylsulfonyl-spiro(indoline-3,4'-piperidine);(af) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dichlorophenylsulfonyl)-(methyl amino))butyl)-1-methylsulfonyl-spiro(indoline-3,4'-piperidine);(ag) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-fluoro-5-(trifluoromethyl)benzoyl )(methylamino))butyl)-1-acetyl-spiro(indoline-3,4'-piperidine);(ah) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-acetyl-spiro(indoline-3,4'-piperidine);(ai) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3-bromo-5-methylbenzoyl)(methylamin o))butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine);(aj) 1'-(3-((S)-(3,4-Dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-(2-aminoacetyl)-spiro(indoline-3,4'-piperidine); and(ak) 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(3,5-dimethylbenzoyl)(methylamino))b utyl)-1-methyl-spiro(indol-2-one-3,4'-piperidine).