Patent ID: 6765114
Filing Date: 2004-07-20
Classification: C07C

Abstract:
A process for preparing pure 1-(aminoethyl)-cyclohexyl-acetic acid or a pharmaceutically acceptable salt thereof which comprises the steps of(a) catalytically hydrogenating a compound of the Formula (II) â€ƒwherein R is hydrogen, benzyl or diphenylmethyl or aryl which is unsubstituted or substituted by a C1 to C4 alkyl or alkoxy group in the presence of a hydrogenation catalyst in an inert organic solvent at a temperature of 10 to 50Â° C. under 1 to 20 kPa pressure to directly obtain the 1-(aminomethyl)-cyclohexyl-acetic acid in the inert organic solvent; (b) filtering the 1-(aminomethyl)-cyclohexyl-acetic acid in the inert organic solvent prepared according to step (a) to remove the hydrogenation catalyst to obtain a filtrate; c) concentrating the filtrate by removing a portion of the inert organic solvent to obtain pure 1-(aminomethyl)-cyclohexyl-acetic acid; and (d) in the case where a pharmaceutically acceptable salt is to be formed transforming the pure 1-(aminomethyl)-cyclohexyl-acetic acid into a pharmaceutically acceptable salt.