Patent ID: 8431612
Filing Date: 2013-04-30
Classification: A61P,C07C

Abstract:
1. A compound according to structural formula (I) including salts and hydrates thereof, wherein: R is a residue of a phorbol ester, wherein the phorbol ester is ingenol-3-acetate, ingenol-3-propionate, ingenol-3-palmitate, ingenol-3-angelate or ingenol-3-benzoate; X is an alkylene chain containing from 1 to 12 carbon atoms; R′ is a moiety that is ionizable at a pH in the range of about 2.0-8.0, wherein R′ comprises a carboxyl group of the formula —(CH the illustrated —X—O—C(O)—R′ group is linked to the 6-carbon of R; and the illustrated —X—O—C(O)—R′ group hydrolyzes under biological conditions to yield a group of the formula —X—OH.