Patent ID: 9138491
Filing Date: 2015-09-22
Classification: A61K

Abstract:
1. A method for preparing a nanoparticle composite containing a magnetic resonance imaging nano-contrast agent encapsulated in a polymer composite formed by an ionic bond between an anionic polymer and a cationic polymer, wherein the method comprises the steps of: (a) obtaining an anionic polymer/magnetic resonance imaging nano-contrast composite by mixing an organic solvent solution containing the anionic polymer with an organic solvent solution containing the magnetic resonance imaging nano-contrast agent and coating the anionic polymer on the magnetic resonance imaging nano-contrast agent to induce phase transfer from an organic phase to an aqueous phase; and (b) obtaining the nanoparticle composite containing the magnetic resonance imaging nano-contrast agent encapsulated in the polymer composite formed by an ionic bond between the anionic polymer and the cationic polymer by adding the cationic polymer to the obtained anionic polymer/magnetic resonance imaging nano-contrast composite; wherein the anionic polymer is selected from the group consisting of polyglutamic acid, polyacrylic acid, alginate, carrageenan, hyaluronic acid, poly(styrene sulfonate), carboxymethylcellulose, cellulose sulfate, heparin, heparin sulfate, poly(methylene-co-guanidine), and condroitin sulfate.