Patent ID: 7507871
Filing Date: 2009-03-24
Classification: A01K,A61K,C12N,G01N,Y10S

Abstract:
1. A rat diabetes model, wherein the rat develops symptoms of type II diabetes and progressive diabetic nephropathy with nodule formation and wherein the rat is a T2DN rat comprising mitochondrial genome and loci on chromosomes 2 (D2Rat12), 11 (D11Rat93), 16 (D16Rat15), 19 (D19Rat59), and X (DXMit4 and DXMit42) from a Fawn Hooded rat into a GK rat, wherein the T2DN rat does not comprise GK alleles at markers D3Rat57, D11Mgh5, D12Rat22, D1Rat 291, D1Mit18, D1Mit34, D1Mgh12, and D1Rat85, and wherein the T2DN rat develops progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy.