Patent ID: 6982251
Filing Date: 2006-01-03
Classification: A61K,C07H

Abstract:
1. A compound represented by the Formula (IA): or a pharmaceutically acceptable salt or solvate thereof, wherein in Formula (IA): R G is selected from the group consisting of: H, wherein R, R W is independently selected from the group consisting of —NH—C(O)—, —O—C(O)—, —O—C(O)—N(R R R R R T is independently selected from the group consisting of phenyl, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, benzothiazolyl, thiadiazolyl, pyrazolyl, imidazolyl and pyridyl; R G wherein R 33 is independently selected from the group consisting of R 34 -substituted alkyl, (R 35 )(R 36 )alkyl-, R R R G wherein R 37 and R 38 are each independently selected from the group consisting of (C 1 -C 6 )alkyl and aryl; R provided that when R 1 is H, R 26 is not H, —OH, —OCH 3 or —O-G; Ar Ar L is selected from the group consisting of: wherein M is —O—, —S—, —S(O)— or —S(O) 2 —; X, Y and Z are each independently selected from the group consisting of —CH R R R R or R d is 1, 2 or 3; h is 0, 1, 2, 3 or 4; s is 0 or 1; t is 0 or 1; m, n and p are each independently selected from 0-4; provided that at least one of s and t is 1, and the sum of m, n, p, s and t is 1-6; provided that when p is 0 and t is 1, the sum of m, n and p is 1-5; and provided that when p is 0 and s is 1, the sum of m, t and n is 1-5; v is 0 or 1; j and k are each independently 1-5, provided that the sum of j, k and v is 1-5; Q is a bond, —(CH wherein R R a and b are each independently 0, 1, 2 or 3, provided both are not zero; provided that when R and when Q is a bond and L is then Ar 1 can also be pyridyl, isoxazolyl, furanyl, pyrrolyl, thienyl, imidazolyl, pyrazolyl, thiazolyl, pyrazinyl, pyrimidinyl or pyridazinyl; R R R R R