Patent ID: 8389484
Filing Date: 2013-03-05
Classification: A61P,C12N,G01N

Abstract:
1. A method for inhibiting protein expression from a target mRNA, the method comprising contacting cells normally expressing the protein from the target mRNA, wherein the target mRNA has been identified as comprising a polymorphism leading to an altered secondary structure from the allelic form of the mRNA, with a small molecule inhibitor, the inhibitor comprising a first moiety which binds to a cellular protein that is present in cellular compartment(s) in which the target mRNA is present; a second moiety which binds to the altered secondary structure of the target mRNA, wherein the second moiety is an oligonucleotide; and a linker connecting the first moiety and the second moiety, wherein the small molecule inhibitor inhibits protein expression from the target RNA by binding to both the cellular protein and to the target mRNA to form a complex.