Patent ID: 6630469
Filing Date: 2003-10-07
Classification: A61K,A61P,C07D

Abstract:
A method of treating sleeping disorders, depression, hypertension, schizophrenia, anxiety, obsessive compulsive disorders and migraine comprising administration to a subject in need thereof an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or hydrate thereof,whereinV, W and X are each N; Y is O, S(O)m, CH2, NR9 or a covalent bond; Z is selected from the group consisting of benzodioxolyl, cyclohexenyl, furanyl, indolyl, napthalenyl, thienyl, pyridinyl and phenyl; optionally substituted with one to five groups, the same or different independently selected from the group consisting of halogen, C1-4alkyl, C1-4haloalkyl, Oâ€”C1-4alkyl, cyano, hydroxy, nitro, NHSO2C1-6alkyl, NR7R8, C(O)NH2 and C1-3alkylene; m and n are each independently 0, 1 or 2; R1 is halogen, C1-6alkyl, C3-7cycloalkyl or NR7R8; R2 is C1-4alkyl substituted with Zâ€², wherein Zâ€² is selected from the group consisting of benzodioxolyl, cyclohexenyl, furanyl, indolyl, napthalenyl, thienyl, pyridinyl and phenyl; optionally substituted with one to five groups, the same or different independently selected from the group consisting of halogen, C1-4alkyl, C1-4haloalkyl, Oâ€”C1-4alkyl, cyano, hydroxy, nitro, NHSO2C1-6alkyl, NR7R8 and C(O)NH2; R3 is hydrogen, C1-6alkyl or C3-7cycloalkyl; R4 and R5 are independently hydrogen or C1-6alkyl or together are C2-3alkylene; R6 is hydrogen or C1-3alk(en)ylene provided that if R6 is C1-3alk(en)ylene, it is attached to Z; R7 and R8 are independently selected from the group consisting of hydrogen, C1-6alkyl, C3-7cycloalkyl, SO2 C1-6alkyl; or R7 and R8 together with the nitrogen to which they are attached can form a 5 to 8 membered heterocycle; said heterocycle optionally containing a second heteroatom selected from the group consisting of N, O and S; said heterocycle being optionally substituted with up to three of the same or different substituents independently selected from C1-6alkyl or Oâ€”C1-6alkyl; and R9 is hydrogen or (C1-6)alkyl.