Patent ID: 6372723
Filing Date: 2002-04-16
Classification: A61K,A61P

Abstract:
A method of reducing restenosis that occurs following a revascularization procedure, comprising:administering to a mammal in need of such treatment a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an active agent selected from the group consisting of: (a) a selective adenosine A2A receptor agonist, (b) the combination of a selective adenosine A1 antagonist and either a selective adenosine A2A receptor agonist or a non-selective adenosine agonist, and (c) a selective adenosine A1 antagonist in order to block the adenosine A1 receptor activation by endogenously released adenosine; wherein said active agent is administered starting at a selected time prior to a revascularization procedure and is administered in an effective amount such that restenosis is reduced.