Patent ID: 8404664
Filing Date: 2013-03-26
Classification: A61K,A61P,C07F

Abstract:
1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: B is a bisphosphonate is selected from the group consisting of: wherein: each R* is independently selected from the group consisting of H, lower alkyl, cycloalkyl, aryl and heteroaryl, with the proviso that at least two R* are H; X is H, OH, NH X L is a cleavable linker for coupling B to A; m is 1, 2, 3 or 4; and A is a Rifamycin having a structure represented by the following Formula A1: wherein: X is H— or R each Y is independently selected from the group consisting of H— and RO—, wherein R is H—, R  is selected from the group consisting of formulae A2-A10: wherein R R R W W  wherein R T is a halogen or R Z is O, S or NR wherein at least one of said B-L- is coupled to a nitrogen atom on said Rifamycin A, and wherein each of said B-L- coupled to a nitrogen atom is independently selected from the group consisting of: wherein: B represents said bisphophonate; n is an integer ≦10; each p is independently 0 or an integer ≦10; each R q is 2 or 3; X is O, —CONR R