Patent ID: 6214857
Filing Date: 2001-04-10
Classification: A61P,C07D

Abstract:
A method of reducing levels of TNF.alpha. in a mammal which comprises administering thereto an effective amount of a hydroxamic acid derivative selected from the group consisting of(a) a compound of formula: ##STR6##whereina carbon atom designated by * constitutes a center of chirality; each of R.sup.1 and R.sup.2,(i) when R.sup.1 and R.sup.2 taken independently of R.sup.2 and R.sup.1, respectively, is hydrogen or lower alkyl, or(ii) when taken together with the carbon atoms to which each is bound as depicted in the formula, is o-phenylene, o-naphthylene or cyclohexene-1,2-diyl, unsubstituted or substituted with 1 to 4 substituents each selected independently from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkylamino, diakylamino, acylamino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, and halo;R.sup.4 is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, or benzyl;R.sup.4 ' is hydrogen or alkyl of 1 to 6 carbon atoms;R.sup.5 is --CH.sub.2,--CH.sub.2 --CO--, --CO--, --SO.sub.2, --S--, or --NHCO--;R.sup.3 is phenyl substituted with 1 to 4 substituents selected from the group consisting of is nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, acetyl, carbamoyl, acetoxy carboxy, hydroxy, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, cycloalkoxy of 3 to 6 carbon atoms, C.sub.4 -C.sub.6 -cycloalkylidenemethyl, C.sub.3 -C.sub.10 -alkylidenemethyl, indanyloxy, or halo; andn has a value of 0, 1, or 2; and(b) acid addition salts of said compound which contain a nitrogen atom capable of being protonated.