Patent ID: 6676927
Filing Date: 2004-01-13
Classification: A61K

Abstract:
A method for selecting an anti-tumor antibody comprising:(a) administering an antibody to a first non-human immunodeficient animal which is implanted with a human tumor; (b) administering said antibody to a second non-human immunodeficient animal which is implanted with said human tumor and said second animal is deficient in Fc&ggr;RI, Fc&ggr;RII, or Fc&ggr;RIII; and (c) determining the ability of said antibody to retard tumor implant growth through an Fc gamma receptor pathway in the animal of step (a) as compared to the animal of step (b) wherein the ability of an antibody to retard tumor growth in step (a) is indicative of an anti-tumor antibody.