Patent ID: 8377701
Filing Date: 2013-02-19
Classification: A61P,C07K

Abstract:
1. A crystal of a complex of sortilin, consisting of the amino acid sequence of SEQ ID NO:33; with a ligand; wherein the crystal is selected from the group consisting of: (a) a tetragonal crystal of said sortilin and the ligand: NGF pro domain (SEQ ID NO:40), wherein said crystal in space group P4 (b) a tetragonal crystal of said sortilin and the ligand: peptide-4, said peptide-4 (SEQ ID NO:39), wherein and crystal is in space group P4 (c) a monoclinic crystal of said sortilin and the ligand: neurotensin (SEQ ID NO:10), wherein and crystal is in space group C2 with unit cell dimensions of a=145.8 Å, b=74.5 Å, c=108.3 Å, α=γ=90°, β=131.87°, (d) a monoclinic crystal of said sortilin and the ligand: neurotensin (SEQ ID NO:10), wherein and crystal is in space group C2 with unit cell dimensions of a=162.1 Å, b=78.7 Å, c=111.1 Å, α=γ=90°, β=126.61°, and (e) a monoclinic crystal of said sortilin and the ligand: sSort-propeptide (SEQ ID NO:49), wherein and crystal is in space group C2 with unit cell dimensions of a=162.1 Å, b=78.1 Å, c=111.7 Å, α=γ=90°, β=127.20°.