Patent ID: 6133270
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A compound having the formula ##STR121## wherein: R.sub.1 and R.sup.2 independently are hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, substituted or unsubstituted phenyl-(CR.sup.6 R.sup.7).sub.m -, substituted or unsubstituted Het(CR.sup.6 R.sup.7).sub.m -, O--C.sub.1 -C.sub.6 alkyl, hydroxy, cyano, nitro, N.sup.3 R.sup.4, NR.sup.3 COR.sup.4, CO.sub.2 R.sup.3, CONR.sup.3 R.sup.4, S(O).sub.m R.sup.3, SO.sub.3 H, S(O).sub.m NR.sup.3 R.sup.4, COR.sup.3 or taken together are oxo (O.dbd.) or methylenedioxy(--O--CH.sub.2 --O--);m is 0, 1, or 2; andR.sup.3 and R.sup.4 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, Het(CR.sup.6 R.sup.7).sub.m -, or phenyl-(CR.sup.6 R.sup.7).sub.m -;R.sup.5 is substituted C.sub.1 -C.sub.6 alkyl, CO substituted C.sub.1 -C.sub.6 alkyl; substituted C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted Het(CR.sup.6 R.sup.7).sub.m -, wherein the substituent groups are CO.sub.2 R.sup.3, CONR.sup.3 R.sup.4, S(O).sub.m R.sup.3, SO.sub.3 H, S(O).sub.m NR.sup.3 R.sup.4, or COR.sup.3 ;R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CO.sub.2 R.sup.3, hydroxy, CONR.sup.3 R.sup.4, or cyano;and the pharmaceutically acceptable salts and solvates thereof.