Patent ID: 6454811
Filing Date: 2002-09-24
Classification: A61F,A61L,B29C,B29L,B33Y

Abstract:
A porous device for tissue engineering formed by solid free form fabrication comprisinga first region having a first pore size, porosity, macroarchitecture, microarchitecture, and composition selected to promote attachment, proliferation, and/or differentiation of a first cell type; and a second region seamlessly joined to the first region by a transition zone, wherein the second region has a second pore size, porosity, macroarchitecture, microarchitecture, and/or composition selected to (i) promote attachment, proliferation, and/or differentiation of a second cell type, or (ii) limit attachment or proliferation of either the first or second cell type, wherein the transition zone has gradients of pore size, porosity, macroarchitecture, microarchitecture, and/or composition effective to avoid delanination of the first or second regions.