Patent ID: 6689922
Filing Date: 2004-02-10
Classification: A61P,C07C

Abstract:
A compound having the formula (I): wherein:R1 represents a methyl radical or a radical â€”(CH2)nâ€”OR7; R2 represents a radical â€”(CH2)nâ€”OR8; Xâ€”Y represents a bond selected from the group consisting of the bonds of the following formulae (a) and (b) which are read from the left to the right or conversely: R3 represents the chain in vitamin D2 or in vitamin D3, wherein the dotted lines represent the bond linking the R3 chain to the benzene ring represented in formula (I);or R3 represents a chain having from 4 to 8 carbon atoms which is substituted with one or more hydroxyl groups, the hydroxyl groups being optionally protected in the form of acetoxy, methoxy, ethoxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, or tetrahydropyranyloxy and the chain optionally in addition has at least one feature selected from the following group: which is substituted with one or more lower alkyl groups or cycloalkyl groups; which is substituted with one or more halogen atoms; which is substituted with one or more CF3 groups; wherein one or more carbon atoms of the chain are replaced by one or more oxygen, sulfur or nitrogen atoms, the nitrogen atoms being optionally substituted with lower alkyl radicals; and wherein one or more single bonds of the chain are replaced by one or more double and/or triple bonds; R3 being positioned on the benzene ring at the para or meta position with respect to the Xâ€”Y bond; R4, R5 and R6, which are identical or different, represent a hydrogen atom, a lower alkyl radical, a halogen atom, a radical â€”OR10, or a polyether radical; n is 0, 1 or 2; R7 and R8, which are identical or different, represent a hydrogen atom, an acetyl radical, a trimethylsilyl radical, a tert-butyldimethylsilyl radical, or a tetrahydropyranyl radical; R9 represents a hydrogen atom or a lower alkyl radical; W represents an oxygen atom, a sulfur atom, a radical â€”CH2â€” or a radical â€”NHâ€” which is optionally substituted with a lower alkyl radical; and R10 represents a hydrogen atom or a lower alkyl radical; or an optical or geometric isomer of the compound of formula (I) or a salt thereof.