Patent ID: 6165468
Filing Date: 2000-12-26
Classification: A61K,A61P

Abstract:
A method of producing an immunogenic product consisting of antigenically active carbohydrate moieties (ACM) which are each covalently coupled via identical divalent bridge groups to immunologically active carriers (IAC) containing amino groups, wherein said divalent bridge group has the following structural formula ##STR5## which comprises the steps of reductive amination of antigenically active carbohydrate moieties (ACM) to introduce amino groups on said moieties (ACM--NH.sub.2), followed by thiolation of said amino groups with iminothiolane ##STR6## whereupon the so produced thiolated products are covalently coupled to immunologically active carriers (IAC) containing amino groups activated by treatment with N-hydroxysuccinimide bromoacetate, to produce said immunogenic product;with the provisos that said antigenically active carbohydrate moieties are not T helper cell dependent and said immunologically active carriers comprise T cell epitopes.