Patent ID: 9114173
Filing Date: 2015-08-25
Classification: A61K,A61P,B82Y,C07K,C12N,C12Y,G01N

Abstract:
1. A method of delivering at least one substance to an organism, comprising administering to the organism an assembled vault-like particle, wherein said assembled vault-like particle comprises: i) multiple copies of a naturally occurring sequence of major vault protein (MVP) having an N-terminal and a C-terminal and having at least one modification selected from the group consisting of addition of an amino acid sequence to the N-terminal, addition of an amino acid sequence to the C-terminal, deletion of between 1 to 100 amino acid residues from the C-terminal, deletion of between 1 to 100 amino acid residues from the N-terminal, and substitution of at least one amino acid residue of the naturally occurring sequence of MVP, and ii) the at least one substance.