Patent ID: 6296870
Filing Date: 2001-10-02
Classification: A61K

Abstract:
A liposome containing an active agent, wherein the lipid bilayer of the liposome comprises:a) phospholipid;b) an active agent associated with the lipid bilayer;c) surfactant with a Critical Micelle Concentration (CMC) of about 1 millimolar or less, said surfactant contained in the lipid bilayer in an amount sufficient to increase the amount of active agent associated with the lipid bilayer, compared to that amount of active agent that would associate with the lipid bilayer in the absence of surfactant, wherein the active agent is aggregated with said surfactant to form micelles; andd) from 3 mole percent to 60 mole percent of cholesterol present in the lipid bilayer in an amount sufficient to protect against the disruptive effects of the surfactant contained in the lipid bilayer,wherein the lipid bilayer is unilaminar.