Patent ID: 7241744
Filing Date: 2007-07-10
Classification: A61K,A61P

Abstract:
1. A method of treating anemia in a patient, the anemia being caused by a decrease in red blood cell production, comprising: (a) administering into the muscle of the subject an effective amount of a plasmid expression construct encoding HV-GHRH (SEQ ID NO: 1), wherein the encoded HV-GHRH is operably linked to a SPc5-12 promoter of the plasmid expression construct, and wherein the plasmid expression construct is mixed with a transfection-facilitating polypeptide; (b) electroporating the muscle having the effective amount of plasmid expression construct encoding the HV-GHRH (SEQ ID NO: 1), wherein the subject is a domesticated animal or human and wherein the HV-GHRH is biologically active and expressed in the muscle cells and released by the muscle cells causing a facilitation of growth hormone secretion and thereby causing increased red blood cell production, thereby treating the anemia.