Patent ID: 9206471
Filing Date: 2015-12-08
Classification: B82Y,C12N,C12Q

Abstract:
1. A replicable artificial composition comprising, at least two particles, A′ and B′, having an A′-B′ bond therebetween comprising a double-stranded DNA having an adenine-thymine/thymine-adenine pairing, further comprising a surface-exposed first single-stranded nucleic acid on particle A′ and a surface-exposed second single-stranded nucleic acid on particle B′; and at least two particles, A and B, having an A-B bond therebetween comprising a double-stranded DNA having an adenine-thymine/thymine-adenine pairing, further comprising a surface-exposed third single-stranded nucleic acid on particle A and a surface-exposed fourth single-stranded nucleic acid on particle B, the first single-stranded nucleic acid on particle A′ specifically and reversibly interacting with the surface-exposed third single-stranded nucleic acid on particle A and the second single-stranded nucleic acid on particle B′ specifically and reversibly interacting with the surface-exposed fourth single-stranded nucleic acid on particle B; wherein the A′-B′ bond and the A-B bond are irreversible under conditions in which interactions of the third single-stranded nucleic acid of particle A and the first single-stranded nucleic acid of particle A′ and interactions of the fourth single-stranded nucleic acid of particle B and the second single-stranded nucleic acid of particle B′ are reversible; further wherein the first single-stranded nucleic acid and the third single stranded nucleic acid do not hybridize through adenine-thymine/thymine-adenine pairings and the second single-stranded nucleic acid and the fourth single-stranded nucleic acid do not hybridize through adenine-thymine/thymine-adenine pairing and the irreversible conditions comprise psoralen mediated cross-linking.