Patent ID: 6683162
Filing Date: 2004-01-27
Classification: A61K,A61P

Abstract:
An 225Ac complex comprising a functionalized chelant compound having the structure wherein R is independently â€”CHQCO2X; Q is independently hydrogen; â€”C1-4-alkyl or â€”(C1-2-alkyl) phenyl; X is independently hydrogen; benzyl or â€”C1-4-alkyl; and Z1 is â€”(CH2)nY wherein n is 1 to 10 and Y is an electrophilic or nucleophilic moiety and Z2 is R; or, in the alternative, Z1 is hydrogen and Z2 is a peptide linker composed of 1-10 amino acids; with the proviso that when R and Z2 are CH2CO2H, Z1 is not (CH2)(1-6)Y; wherein Y comprises a para-substituted phenyl group, said phenyl substituent having a free end group Comprising â€”NO2, â€”NH2, â€”NCS, â€”COOH, â€”OCH2COOH, â€”OCH2COOH, â€”NHCOCH2Br or â€”NHCOCH2I; or a pharmaceutically acceptable salt thereof complexed with 225Ac; further comprising an antibody or fragment thereof, a growth factor or a cytokine that is covalently attached to Y or to said peptide linker.