Patent ID: 8389480
Filing Date: 2013-03-05
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A polypeptide comprising: a) a first domain comprising an intracellular loop, or a fragment thereof, of a G protein coupled receptor (GPCR), wherein said GPCR is a Class A or Class B GPCR, and wherein said fragment comprises at least 3 contiguous amino acid residues of the intracellular loop, and b) a second domain, attached to the first domain, wherein said second domain comprises a cell-penetrating, membrane-tethering hydrophobic moiety comprising: a tridecanoyl (C wherein said polypeptide does not comprise an extracellular portion of the GPCR; and wherein said polypeptide is an agonist or antagonist of said GPCR.