Patent ID: 9200009
Filing Date: 2015-12-01
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by the formula (I-1): wherein: Q is: cycloalkyl that is optionally substituted and optionally condensed, cycloalkenyl, aryl that is optionally substituted and optionally condensed, or a heterocyclic group selected from a 5-7 membered saturated or unsaturated non-aromatic ring having at least one of nitrogen, oxygen, phosphorus and sulfur atoms in the ring and a 5-8 membered aromatic ring having one to four of oxygen, sulfur, phosphorus and nitrogen atoms in the ring, wherein said heterocyclic group is optionally substituted and optionally condensed; R the A ring is an optionally substituted heterocycle selected from any of (a)-(i): wherein Z is O; R the broken line represents the presence or absence of a bond; with the proviso that when the broken line represents the presence of a bond, R when a substituent is present on said “optionally substituted lower alkyl”, “optionally substituted cycloalkyl”, “optionally substituted cycloalkyl lower alkyl”, “optionally substituted lower alkenyl”, “optionally substituted lower alkoxy”, “optionally substituted aryl”, “optionally substituted aryl lower alkyl”, “optionally substituted aryloxy”, “optionally substituted heterocycle”, “optionally substituted heterocyclic group”, “optionally substituted heterocyclyl lower alkyl”, “optionally substituted heterocyclyloxy”, “optionally substituted lower alkenyloxy”, “optionally substituted lower alkylcarbonyl”, “optionally substituted cycloalkylcarbonyl”, “optionally substituted cycloalkyl lower alkylcarbonyl”, “optionally substituted lower alkoxycarbonyl”, “optionally substituted arylcarbonyl”, “optionally substituted aryl lower alkylcarbonyl”, “optionally substituted aryloxycarbonyl”, “optionally substituted heterocyclylcarbonyl”, “optionally substituted heterocyclyl lower alkylcarbonyl”, “optionally substituted heterocyclyloxycarbonyl”, “optionally substituted lower alkylene”, “optionally substituted lower alkenylene”, or “optionally substituted phosphoric acid residue”, each substituent may be the same or different, 1 to 4 group(s) selected from Substituent group B and Substituent group A at any position; Substituent group B consists of hydroxy, carboxy, halogen, halo lower alkyl, halo lower alkoxy, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkenyl, lower alkoxy, lower alkenyloxy, lower alkoxycarbonyl, nitro, nitroso, optionally substituted amino, azido, aryl, aralkyl, cyano, isocyano, isocyanato, thiocyanato, isothiocyanato, mercapto, alkylthio, alkylsulfonyl, methanesulfonylamino, ethanesulfonylamino, N-methylsulfonyl-N′-methylamino, optionally substituted carbamoyl, sulfamoyl, acyl, formyloxy, haloformyl, oxalo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, sulfino, sulfo, sulfoamino, hydrazino, azido, ureido, amidino, guanidino, phthalimido, oxo, phosphoric acid residue, phosphoric-acid-residue-substituted lower alkyl (which may be intervened by a heteroatom group), aryl substituted with a phosphoric acid residue, aralkyl substituted with a phosphoric acid residue, and hydroxy lower alkyl; Substituent group A consists of alkyl, lower alkoxy, halogen, halogenated lower alkyl, halogenated lower alkoxy, and the formula: wherein X X X X X X X X X R is a group independently selected from the following group: (1) lower alkyl, (2) lower alkoxy, (3) halogen, (4) halogenated lower alkyl, (5) halogenated lower alkoxy, and (6) lower cycloalkyl; and m is an integer of 0 to 5; the substituent of said “optionally substituted amino” or “optionally substituted carbamoyl” is independently selected from mono- or di-lower alkyl, lower alkylcarbonyl, or lower alkylsulfonyl, optionally substituted lower alkyl, lower alkoxy lower alkyl, formyl, optionally substituted lower alkylcarbonyl, lower alkoxy lower alkylcarbonyl, lower alkylcarbamoyl lower alkylcarbonyl, alkoxycarbonylacetyl, optionally substituted arylcarbonyl, optionally substituted aralkyl, hydroxy, methanesulfonyl, ethanesulfonyl, isopropylsulfonyl, 2,2,2-trifluoroethanesulfonyl, benzylsulfonyl, methoxyethylsulfonyl, arylsulfonyl optionally substituted with lower alkyl or halogen, cycloalkyl, aryl optionally substituted with lower alkyl, lower alkylaminosulfonyl, lower alkylaminocarbonyl, lower alkoxycarbonyl, cycloalkylcarbonyl, sulfamoyl, methylsulfamoyl, dimethylsulfamoyl, lower alkylcarbonylamino, heterocycle, and optionally substituted amino, wherein any two substituents on the amino group of “optionally substituted amino”, “optionally substituted aminocarbonyl”, or “optionally substituted carbamoyl” may together with the adjacent nitrogen atom may form a nitrogen-containing heterocycle which may contain at least one of sulfur and oxygen atoms in the ring, wherein the ring is optionally substituted with oxo or hydroxy, and the sulfur atom forming the ring may be substituted with oxo;