Patent ID: 6083977
Filing Date: 2000-07-04
Classification: C07C,C07D,Y10S

Abstract:
A compound of the formulae: ##STR12## wherein: R.sup.1, R.sup.2 and R.sup.4 each independently are hydrogen, aryl, heteroaryl, CF.sub.3 or a C.sub.2 -C.sub.6 alkyl, fluoroalkyl or perfluoroalkyl optionally substituted with .sup.14 CH.sub.3, .sup.13 CH.sub.3, CD.sub.3, C.sup.3 H.sub.3, and/or .sup.13 CD.sub.3 ;R.sup.3 is each independently are hydrogen, CF.sub.3, a C.sub.1 -C.sub.3 alkyl, a C.sub.1 to C.sub.3 fluoroalkyl or perfluoroalkyl, or OR.sup.6, where R.sup.6 is hydrogen, CF.sub.3, a C.sub.1 -C.sub.2 alkyl or a C.sub.1 to C.sub.2 fluoroalkyl or perfluoroalkyl, provided, however, that R.sup.1 cannot be CF.sub.3 or alkyl, fluoroalkyl or perfluoroalkyl when R.sup.3 is CF.sub.3 or alkyl, fluoroalkyl or perfluoroalkyl;R.sup.9 is a C.sub.1 -C.sub.4 alkyl;R.sup.10 through R.sup.15 each independently are hydrogen, a C.sub.1 -C.sub.6 alkyl or CF.sub.3 ;X is COOR.sup.16, CONHR.sup.17, or CONR.sup.17 R.sup.18 where R.sup.16 represents hydrogen or a C.sub.1 -C.sub.6 alkyl, and where R.sup.17 and R.sup.18 each independently represent a C.sub.1 -C.sub.6 alkyl, or an aryl or heteroaryl optionally substituted with OH, F, Br, Cl or I, provided, however, that R.sup.17 and R.sup.18 both cannot be an aryl or heteroaryl;Y is C, O, S or N, provided that, when Y is O, then R.sup.14 and R.sup.15 do not exist, and when Y is N, then R.sup.14 and R.sup.15 cannot be CF.sub.3, and when Y is S, then R.sup.14 and R.sup.15 can independently or together represent O, or may be absent altogether;W is N or CR.sup.16, where R.sup.16 has the same definition given above;R.sup.19 is an aryl or heteroaryl optionally substituted with one or more substituents selected from the group consisting of hydrogen, F, Cl, Br, I or a C.sub.1 -C.sub.6 alkyl, wherein X has the same definition given above;n is 0, 1 or 2;the dotted lines designate optional double bonds; andthe wavy lines depict carbon to carbon bonds in either the cis or trans configurations, provided, however, that when R.sup.1, R.sup.2 and R.sup.4 are all hydrogen, then R.sup.3 cannot be aryl.