Patent ID: 6822076
Filing Date: 2004-11-23
Classification: A61K,C07K,Y02A

Abstract:
A hybrid protein comprising:(i) protein capable of binding to a receptor at least one cell type selected from the group consisting of mastocytes and basophils and of being endocyted by the at least one cell type selected from the group consisting of the mastocytes and basophils: (ii) a protease capable of cleaning one or more secreted proteins of the at least one cell type selected from the group consisting of the mastocytes and basophils so as to inhibit the secretion process without killing the at least one cell type selected from the group consisting of the mastocytes and basophils, wherein the protease (ii) is selected from the group consisting of: light chain of a Clostridium botulinum neurotoxin; proteolytically active fragment of the light chain of a Clostridium botulinum neurotoxin containing an amino acid sequence of SEQ ID NO:1 His-Xaa-Xaa-Xaa-His-Xaa-Xaa-His, wherein Xaa is any amino acid. light chain of the tetanus toxin (TeNT); proteolytically active fragment of the light chain of the tetanus toxin containing an amino acid sequence of SEQ ID NO:2 His-Asp-Leu-lIe-His-Val-Leu-His; IgA protease of Neisseria gonorrhoeae; and proteolytic domain of the IgA protease of Neisseria gonorrhoeae.