Patent ID: 9169262
Filing Date: 2015-10-27
Classification: A61P,C07C,C07D

Abstract:
1. A crystalline polymorphically stable salt, in anhydrous form, of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (Asenapine) with an organic di-acid or tri-acid, wherein the organic di-acid or tri-acid is malonic acid or citric acid, wherein said salt has a solubility in water at 25° C. of more than 2.0 mg/ml, calculated as free base and wherein the polymorphic stability is such that at least 90 wt. % of said salt maintains its crystal form upon stirring in acetonitrile for 96 hours at a temperature of 20° C.