Patent ID: 8785656
Filing Date: 2014-07-22
Classification: C07D

Abstract:
1. A telescoping process for synthesizing 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt (I), the process comprising the steps of: a) synthesizing the intermediate 3-hydrazinylpropanenitrile (IV) via a 1,4 Michael addition using acrylonitrile (III) and hydrazine hydrate; b) synthesizing the intermediate 3-(2-alkylidenehydrazinyl)propanenitrile (VI) via a condensation with intermediate (IV) and aldehyde (V): wherein R is a mono- or poly-substituted or unsubstituted, straight or branched, saturated or mono- or poly-unsaturated alkyl group; c) synthesizing the intermediate 5-amino-1-alkyl-1H-pyrazole (VII) via a cyclisation with intermediate (VI) in the presence of a base; d) synthesizing 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt (I) via a nitrosation step with intermediate (VII) in the presence of an acid HZ;