Patent ID: 6346546
Filing Date: 2002-02-12
Classification: A61K,A61P,A61Q,C07D

Abstract:
Biaromatic compounds connected by a propynylene or ailenylene bond, corresponding to the following formula (I): in which:Ar represents a radical of the following formula (a): R1 represents â€”CH3, â€”CH2â€”Oâ€”R6, â€”OR6 or â€”COR7, R2 represents â€”OR8, â€”SR8 or a polyether radical, if, in the latter case, R4 represents linear or branched C1-C20 alkyl and is at the ortho or meta position with respect to the Xâ€”Ar bond, R3 represents lower alkyl, or R4 represents H, a halogen, linear or branched C1-C20 alkyl, â€”OR8, a polyether radical or aryl, R5 represents H, a halogen, linear or branched C1-C20 alkyl or an â€”OR8 radical, R6 represents H, lower alkyl or a â€”COR9 radical, R7 represents H, lower alkyl, â€ƒor â€”OR10, R8 represents H, lower alkyl or â€”COR9, R9 represents lower alkyl, R10 represents H, C1-C20 alkyl, which can be linear or branched, alkenyl, mono- or polyhydroxyalkyl, optionally substituted aryl or aralkyl, or a sugar residue, râ€² and râ€³ represent H, lower alkyl, mono- or polyhydroxyalkyl, optionally substituted aryl, or an amino acid or sugar residue, X represents a divalent radical, which, from right to left or vice versa, has the formula: R11 representing H or â€”OR6, R6 having the same meaning as above, R12 representing H or lower alkyl, or R11 and R12, taken together, form an oxo (&boxH;O) radical, and the salts of the compounds of formula (I), when R1 represents a carboxylic acid functional group, and the optical and geometrical isomers of the compounds of formula (I).