Patent ID: 9198981
Filing Date: 2015-12-01
Classification: A61K,C12N

Abstract:
1. A method of treating a condition associated with decreased vascularity in a subject, the method comprising administering to a subject in need thereof having the condition associated with decreased vascularity a compound that increases the bioavailability or biological activity of VEGF by reducing the bioavailability or biological activity of a VEGF inactivating agent, and wherein the administering is sufficient to treat the condition in the subject by increasing vascularity, wherein the condition is selected from the group consisting of preeclampsia, systemic hypertension, cerebrovascular disorders, cardiovascular disorders, peripheral vascular disease, vascular regeneration/recovery, and wound healing disorders and wherein the VEGF inactivating agent is fms-like tyrosine kinase is soluble flt-1 (sflt-1) or membrane bound flt-1 (mbflt-1), and wherein the compound is a nucleic acid molecule.