Patent ID: 9018200
Filing Date: 2015-04-28
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula: or a pharmaceutically acceptable salt thereof, wherein: ring A is (1) aryl, (2) 9 or 10-membered fused aryl, wherein aryl is fused with a heteroaryl or heterocyclyl group, (3) 6-membered heteroaryl, or (4) 9 or 10-membered fused heteroaryl, wherein the heteroaryl or heterocyclyl groups contain 1-2 N atoms; i or n are independently 0 or 1; m is 1 or 2; k is 0, 1, 2, or 3; each R 1 is selected from the group consisting of (1) halo, (2) C (3) haloC (4) hydroxyl, (5) C (6) amino, wherein the alkyl group is unsubstituted or substituted by hydroxy, C R 2a and R 2b are independently hydrogen or halo; each R 3 is independently hydrogen, halo, C 1-6 alkyl, or haloC 1-6 alkyl; R 4 is hydrogen, halo, C 1-6 alkyl, or haloC 1-6 alkyl; and R 5 is selected from the group consisting of (1) oxo, (2) —COOH, (3) —NH—C(O)C (4) —C(O)C (5) —C(O) (6) —C(O)C (7) —C(O)C (8) —C(O)heterocyclyl, (9) —C(O)C (10) —C(O)NH—C (11) —C(O)NH—C (12) —C(O)NH—C (13) —C(O)NH-heterocyclyl, (14) —C(O)NH—C (15) —C(O)NHC (16) —C(O)NHC (17) —SO (18) heteroaryl, and (19) CN; wherein the heteroaryl group is a 5- or 6-membered ring, containing 1-4 N, O, or S atoms; wherein the heterocyclyl group is a 3- to 6-membered ring, containing 1-2 N or O atoms; wherein the alkyl group is unsubstituted or substituted by hydroxy, C 1-3 alkoxy, or halo; and wherein the cycloalkyl, heterocyclyl, or heteroaryl groups are unsubstituted or substituted with 1-3 C 1-6 alkyl, halo, hydroxy, hydroxyC 1-6 alkyl, or C 1-6 alkoxyl groups.