Patent ID: 8865459
Filing Date: 2014-10-21
Classification: G01N,Y10S

Abstract:
1. A nucleic acid analysis device for analysis of nucleic acid in a sample through fluorometry, comprising: a substrate comprising a plurality of metal structures disposed thereon, wherein each of the plurality of metal structures (a) forms a projection above the substrate (b) has a base attached to the substrate and an apex extending above the substrate and (c) consists of one or more metals in which a localized surface plasmon is generated by light irradiation; an insulting layer, wherein the insulating layer is disposed above the substrate and around the plurality of metal structures in a manner that the apex of said each of the plurality of metal structures is exposed and not covered by the insulating layer; a nucleic acid synthase immobilized on the exposed surface of said each of the plurality of metal structures; and a nucleic acid probe bound to the nucleic acid synthase for the analysis of the nucleic acid in the sample, wherein one molecule of the nucleic acid probe is bound to each nucleic acid synthase, and the nucleic acid synthase is disposed in a region on which the localized surface plasmon is generated.