Patent ID: 6271403
Filing Date: 2001-08-07
Classification: C07J

Abstract:
A 17-keto intermediate compound for estratrienes, which is7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoro-pentylthio)-propylamino]-p entyl}-3-(tetrahydropyran-2-yloxy)-estra- 1,3,5(10)-trien- 17-one15.beta.,16.beta.-methano-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoro- pentylthio)-propylamino]-pentyl}-3-hydroxy-estra- 1,3,5(10),15-tetraen- 17-one3-hydroxy-15.beta.-methyl-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoro- pentylthio)-propylamino]-pentyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoropentyltlio) -propylamino]-pentyl}-3-(tetrahydrapyran-2-yloxy)-estra-1,3,5(10)-trien-17- one11.beta.-fluoro-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoropentanesulf onyl)-propylamino]-pentyl}-3-(tetrahydrapyran-2-yloxy)-estra-1,3,5(10)-trie n-17-one3-hydroxy-7.alpha.-{5-[(2S)-2-(4,4,5,5,5-pentafluoropentylthiomethyl)-pyrro lidin-1-yl]-pentyl}-estra-1,3,5(10)-trien-17-one3-hydroxy-7.alpha.-{5-[(2R)-2-(4,4,5,5,5-pentafluoropentylthiomethyl)-pyrro lidin-1-yl]-pentyl}-estra-1,3,5(10)-triene-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{5-[2-(4,4,5,5,5-pentafluoropentyltthiom ethyl)-pyrrolidin-1-yl]-pentyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluorop entylthio)-propylamino]-pentyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluorop entanesulfonyl)-propylamino]-pentyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-7.alpha.-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoropentylthio) -propylamino]-pentyl}-3-hydroxy-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{6-[N-methyl-N-3-(4,4,5,5,5-pentafluorop entylthio)-propylamino]-hexyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{6-[N-methyl-N-3-(4,4,5,5,5-pentafluorop entanesulfinyl)-propylamino]-hexyl}-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-7.alpha.-(5-{[N-3-(furan-2-ylmethylthio)-propyl]-N-methyl-a mino}-pentyl)-3-hydroxy-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-(5-{N-menthyl-[N-3-(thiophen-2-ylmethylt hio)-propyl]-amino}-pentyl)-estra-1,3,5(10)-trien-17-one11.beta.-fluoro-3-hydroxy-7.alpha.-{5-[(2S)-2-(4-trifluoromethylphenylthiom etliyl)-pyrrolidin-1-yl]-pentyl}-estra- 1,3,5(10)-trien-17-one or11.beta.-fluoro-3-hydroxy-7.alpha.-{5-[(2R)-2-(4,4,5,5,5-pentafluoropentyl- thiomethyl)-pyrrolidin-1-yl]-pentyl}-estra-1,3,5(10)-triene-17-one.