Patent ID: 6747045
Filing Date: 2004-06-08
Classification: A61P,C07D

Abstract:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk1 is C1-4alkylcarbonyl, C1-4alkylcarbonylC1-4alkyl, carbonyl, carbonylC1-4alkyl, or C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy, C1-4akylcarbonyloxy, C1-4akylcarbonyloxyC1-4alkyloxycarbonyloxy, or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; â€”Z1â€”Z2â€” is a bivalent radical of formula â€”CH2â€”(e-1),â€”Oâ€”CH2â€”(e-2),â€”Sâ€”CH2â€”(e-3),â€”CH2â€”CH2â€”(e-4),â€”CH2â€”CH2â€”CH2â€”(e-5),â€”CH&boxH;(e-6),â€”CH2â€”CH&boxH;(e-7),â€”CH2â€”CH2â€”CH&boxH;(e-8),â€”CH&boxH;CHâ€”(e-9);â€ƒR1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, C3-6alkenyl, C1-6alkyloxy, trihalomethyl, trihalomethoxy, halo, hydroxy, cyano, nitro, amino, C1-6alkylcarbonylamino, C1-6alkyloxycarbonyl, C1-4alkylcarbonyloxy, aminocarbonyl, mono- or di-(C1-6alkyl)aminocarbonyl, aminoC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, C1-4alkylcarbonyloxy-C1-4alkyloxycarbonyloxy, or C3-6cycloalkylcarbonyloxyC1-4alkyloxy-carbonyloxy; or when R1 and R2 are on adjacent carbon atoms, R1 and R2 taken together may form a bivalent radical of formula â€”CH2â€”CH2â€”CH2â€”(a-1),â€”CH2â€”CH2â€”CH2â€”CH2â€”(a-2),â€”CH2â€”CH2â€”CH2â€”CH2â€”CH2â€”(a-3),â€”CH&boxH;CHâ€”CH&boxH;CHâ€”(a-4),â€”Oâ€”CH2â€”Oâ€”(a-5),â€”Oâ€”CH2â€”CH2â€”(a-6),â€”Oâ€”CH2â€”CH2â€”Oâ€”(a-7),â€”Oâ€”CH2â€”CH2â€”CH2â€”(a-8),â€”Oâ€”CH2â€”CH2â€”CH2â€”CH2â€”(a-9),â€ƒwherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by hydroxy, C1-4alkyl or CH2OH; R4 is hydrogen, C1-6alkyl, or a direct bond when the bivalent radical â€”Z1â€”Z2â€” is of formula (e-6), (e-7) or (e-8); A is a bivalent radical of formula â€ƒwherein the nitrogen atom is connected to Alk1 and, m is 0 or 1; Alk2 is C1-6alkanediyl; R6 is hydrogen, C1-6alkyl, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenylmethyl, C1-4alkylaminocarbonyl, C1-4alkylcarbonyloxy-C1-4alkyloxycarbonyl, or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; R5 is a radical of formula â€ƒwherein n is 1 or 2; X is oxygen, sulfur, NR9 or CHNO2; Y is oxygen or sulfur, R7 is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8 is C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R9 is cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10 is hydrogen or C1-6alkyl; and Q is a bivalent radical of formula â€”CH2â€”CH2â€”(d-1),â€”CH2â€”CH2â€”CH2â€”(d-2),â€”CH2â€”CH2â€”CH2â€”CH2â€”(d-3),â€”CH&boxH;CHâ€”(d-4),â€”CH2â€”COâ€”(d-5),â€”COâ€”CH2â€”(d-6),â€ƒwherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C1-4alkyl, hydroxy or phenyl.