Patent ID: 6858750
Filing Date: 2005-02-22
Classification: A61K,A61P

Abstract:
1. A method of treating a patient suffering from a mitochondrial disease, said method comprising administering to said patient a pharmaceutical composition comprising (i) an individual fumaric acid derivative or (ii) a mixture of fumaric acid derivatives, wherein said (i) or (ii) is selected from the group consisting of (a) fumaric acid diesters of the formula: wherein R 1 and R 2 which may be the same or different independently represent a linear, branched, cyclic, saturated or unsaturated C 1-24 alkyl radical or a C 5-20 aryl radical and wherein these radicals are optionally substituted with halogen (F, Cl, Br, I), hydroxy, C 1-4 alkoxy, nitro or cyano; and (b) fumaric acid monoesters of the formula: wherein R A is hydrogen or an alkali or alkaline earth metal cation or a physiologically-acceptable transition metal cation, and n is 1 or 2 and corresponds to the valence of A; wherein the mitochondrial disease is selected from the group consisting of Parkinson's syndrome, Alzheimer's disease, Chorea Huntington disease, retinopathia pigmentosa, and mitochondrial encephalomyopathy, and wherein one dosage unit of the pharmaceutical composition contains an amount of said fumaric acid derivative(s) which corresponds to 1 to 500 mg of fumaric acid.