Patent ID: 6057318
Filing Date: 2000-05-02
Classification: A61P,C07D

Abstract:
Compound of formula: ##STR188## in which: Z.sub.1 is C.sub.1 -C.sub.4 alkylene or phenylene;when Z.sub.1 is C.sub.1 -C.sub.4 alkylene, W is NR.sub.1 R.sub.2, in which R.sub.1 is selected from H and C.sub.1 -C.sub.4 alkyl, and R.sub.2 is selected from H, C.sub.1 -C.sub.4 alkyl, CONQ.sub.1 Q.sub.2 and CSNQ.sub.1 Q.sub.2 in which Q.sub.1 and Q.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl, SO.sub.2 Q.sub.3 in wich Q.sub.3 is C.sub.1 -C.sub.4 alkyl, COOQ.sub.4 in which Q.sub.4 is selected from C.sub.1 -C.sub.4 alkyl and benzyl, or R.sub.1 and R.sub.2 taken together form with N a saturated heterocycle morpholine, pyrrolidine, piperidine, piperazine or 4-(C.sub.1 -C.sub.3)alkyl-piperazine; or W is N(O)R.sub.1 R.sub.2 in which R.sub.1, R.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl; or W is selected from the group consisting of C.sub.1 -C.sub.4 alkoxy, and C.sub.1 -C.sub.4 thioalkoxy;when Z.sub.1 phenylene, W is NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl;Z.sub.2 is C.sub.1 -C.sub.4 alkylene;Ar.sub.1 and R.sub.3 taken together form the group: ##STR189## in which q is equal to 2 to 4; and Ar.sub.2 is pyridyl, optionally substituted by a radical selected from C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; or a pharmaceutically acceptable acid or base salt thereof.