Patent ID: 7247633
Filing Date: 2007-07-24
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula (I): wherein Y and Z represent both nitrogen and X represents CH, forming a pyrimidine derivative, and wherein R or from a group B, consisting of aryl-C 1 -C 6 -alkyl, aryl-C 1 -C 6 -alkoxy, heteroaryl-C 1 -C 6 -alkoxy, aryloxy-C 2 -C 6 -alkoxy, heteroaryloxy-C 2 -C 6 -alkoxy, 1-indanyloxy, 2-indanyloxy, aryloxy, heteroaryloxy, arylthio, heteroarylthio, C 5 -C 6 -cycloalkylthio, C 5 -C 8 -alkoxy, C 5 -C 8 -alkylthio, C 3 -C 6 -alkynyloxy, C 3 -C 6 -alkenyloxy, fluoro-C 2 -C 4 -alkoxy, C 4 -C 8 -cycloalkyloxy, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkoxy, aryl-C 1 -C 4 -alkylthio, heteroaryl-C 1 -C 4 -alkylthio, aryl-C 1 -C 4 -alkylamino, heteroaryl-C 1 -C 4 -alkylamino, heteroaryl and aryl; with the proviso that: (i) R (iii) when X is CH and Z and Y both are nitrogen in formula (I), forming a pyrirnidine derivative, and R (iv) when X is CH and Z and Y both are nitrogen in formula (I), forming a pyrimidine derivative, and R and where R R and wherein any aryl or heteroaryl residue, alone or as part of another group, in R wherein any aryl or heteroaryl residue as substituents on aryl or heteroaryl, alone or as part of another group, in R R or a pharmaceutically acceptable salt, geometrical isomer, tautomer, optical isomer, or N-oxide form thereof.