Patent ID: 8846324
Filing Date: 2014-09-30
Classification: C07K,G01N

Abstract:
1. An in vitro method for diagnosis or prediction of hypertension and/or early-stage cardiovascular end-organ damage in a patient, the method comprising determining the concentration of soluble prorenin receptor (sPRR) in a sample from the patient using an antibody or antibody fragment that immunologically binds a polypeptide comprising SEQ ID NO:4 wherein the presence of the polypeptide at increased concentration compared to the concentration of such a polypeptide in samples from healthy subjects is indicative for hypertension and/or early-stage cardiovascular end-organ damage and wherein the presence of the polypeptide at decreased concentration compared to the concentration of such a polypeptide in samples from healthy subjects is indicative for late stage cardiovascular end-organ damage.