Patent ID: 7309792
Filing Date: 2007-12-18
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A dimeric compound of formula II, wherein: R1 and R1′ are selected from hydrogen, optionally substituted methyl, and hydroxyl; R2 and R2′ are selected from optionally substituted methyl and optionally substituted ethyl; R3 and R3′ are selected from CH2, NH, O and S; R4 and R4′ are selected from CH and N; R5-R8, and R5′-R8′ are selected from hydrogen, optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, wherein optionally either R6 and R7 as well as R6′ and R7′ or R7 and R8 as well as R7′ and R8′ are connected in 5- to 8-membered rings; and L is a contiguous chain of between 2 and 200 atoms, having a MW between 20 and 2KD that can incorporate substitution, heteroatoms, unsaturation and cyclic aromatic and heteroaromatic portions, covalently linking any of R2, R5, R6 or R7, with any of R2′, R5′, R6′ or R7′, or a pharmaceutically-acceptable salt thereof.