Patent ID: 6489316
Filing Date: 2002-12-03
Classification: A61K,C07D

Abstract:
A compound of Formula (I) wherein:R1, R2, R3, and R4 are independently selected from H, â€”OH and â€”OR6; R5 is selected from hydrogen, an alkali metal cation, an alkaline earth metal cation, ammonium, tetraalkylammonium, alkyl of 1 to 12 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 12 carbon atoms, aralkyl of 7 to 20 carbon atoms, aryl of 6 to 12 carbon atoms and moieties of the formulae: R6 is selected from alkyl of 1 to 12 carbon atoms optionally substituted with alkoxy, halogen, dialkylamino, â€”Oalkyloalkyl, and 1 or 2 phenyl groups; cycloalkyl of 3 to 10 carbon atoms; alkenyl of 2 to 12 carbons; alkyloxacyclopropyl of 3 to 12 carbon atoms; aryl of 6 to 12 carbon atoms; heteroaryl having 5 or 6 ring atoms; bicyclic heteroaryl having 8 to 20 ring atoms; heteroarylalkyl having 5 or 6 ring atoms; and â€”SiR12R13R14; n is an integer of 1 to 3; R7 is alkyl of 1 to 12 carbon atoms; cycloalkyl of 3 to 10 carbon atoms; aralkyl of 7 to 20 carbon atoms; or aryl of 6 to 12 carbon atoms; R8, R9, R10 and R11 are independently selected from alkyl of 1 to 12 carbon atoms; R12, R13, and R14 are independently selected from alkyl of 1 to 12 carbon atoms optionally substituted with â€”OCOR7, â€”CO2R7, alkenyl of 2 to 12 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, and aryl of 6 to 12 carbon atoms; optionally two of R12, R13, and R14 taken together with the silicon atom to which they are attached form a cyclic ring of 5 or 6 ring atoms; provided that at least one of R1, R2, R3, and R4 is hydrogen;or a pharmaceutically acceptable salt thereof.