Patent ID: 6503699
Filing Date: 2003-01-07
Classification: A01N,A61K,A61L,C07D

Abstract:
A method of inactivating microorganisms in blood preparations, comprising, in the following order:a) providing, in any order, i) a compound of the following formula: â€ƒwherein R1 is selected from the group consisting of: â€”(CH2)wâ€”R2â€”(CH2)zâ€”NH2, â€”(CH2)wâ€”R2â€”(CH2)xâ€”R3â€”(CH2)zâ€”NH2, and â€”(CH2)wâ€”R2â€”(CH2)xâ€”R3â€”(CH2)yâ€”R4(CH2)zâ€”NH2; wherein R2, R3, and R4 are independently selected from the group consisting of O and NH, and w is a whole number from 1 to 5, x is a whole number from 2 to 5, y is a whole number from 2 to 5, and z is a whole number from 2 to 6, and R5, R6, and R7 are independently selected from the group consisting of H and (CH2)vCH3, where v is a whole number from 0 to 5, and all salts thereof; ii) a light source for photoactivating said compound; and iii) a blood preparation suspected of being contaminated with a microorganism having nucleic acid;b) adding said compound to said blood preparation; and c) photoactivating said compound under conditions sufficient to inactivate said microorganism.