Patent ID: 7893262
Filing Date: 2011-02-22
Classification: C07D

Abstract:
1. A process for preparing the compound of formula I comprising: a) reacting either a compound of formula 1 with a compound of formula 9 to obtain a compound of formula 2, which is hydrolyzed to the compound of formula 3, which in turn is reduced to a compound of formula 4 and thereafter oxidized to obtain the compound of formula 5; or b) reducing the compound of formula 2 directly to the compound of formula 4, and thereafter oxidizing the compound of formula 4 to form the compound of formula 5; or c) reacting a compound of formula 6 with a compound of formula 9 to obtain the compound of formula 5; and d) transforming the compound of formula 5 into the compound of formula I by reacting the compound of formula 5 which the propionitrile of formula 10 to obtain the compound of formula 11, which is reacted with guanidine to form the compound of formula I, and, if desired, forming a pharmaceutically acceptable salt thereof in a manner known per se