Patent ID: 6794357
Filing Date: 2004-09-21
Classification: A61K

Abstract:
A propellant-free composition consisting of (A) a polypeptide, and (B) one or more surfactant compounds which (i) have a consistency that permits them to be processed into primary particles having a diameter less than 10 microns, and (ii) enhance the systemic absorption of said polypeptide in the lower respiratory tract of a patient, said composition being in the form of a dry powder suitable for inhalation from a dry powder inhaler device, wherein at least 50% of the total mass of (A) and (B) consists of primary particles having a diameter less than 10 microns or equal to about 10 microns, and wherein each of the one or more surfactant compounds is selected from the group consisting of a salt of a fatty acid, bile salt, single-chain phospholipid, double-chain phospholipid in which each chain of the double-chain phospholipid is eight or fewer carbon atoms in length, alkyl glycoside, cyclodextrin or derivative thereof, salt of a glycyrrhizine acid, salt of a saponin glycoside, salt of an acyl carnitine, and sodium salicylate.