Patent ID: 7745446
Filing Date: 2010-06-29
Classification: A61P,C07D

Abstract:
1. A compound of formula I in which R1 is Ar1, or Ar1 is optionally substituted by R11, and is phenyl, naphthyl, fluorenyl or Aa1, in which Aa1 is a bisaryl radical made up of two aryl groups, which are independently selected from the group consisting of phenyl and naphthyl, and which are linked together via a single bond, R11 is 1-4C-alkoxy, 1-4C-alkoxy-2-4C-alkoxy, halogen, nitro, hydroxyl, phenoxy, phenyl-1-4C-alkoxy, hydroxy-2-4C-alkoxy, carboxy-1-4C-alkoxy or 1-4C-alkylcarbonylamino, Har1 is optionally substituted by R12, and is an unsaturated monocyclic 5- or 6-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which R12 is 1-4C-alkyl, Har2 is optionally substituted by R13, and is an unsaturated fused bicyclic 9- or 10-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which R13 is 1-4C-alkyl, Har3 is optionally substituted by R14, and is an unsaturated fused tricyclic 13- or 14-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which R14 is 1-4C-alkyl, Cyc1 is a group of formula A in which G is a 5- or 6-membered saturated or partially unsaturated heterocyclic ring comprising one or two heteroatoms independently selected from the group consisting of oxygen and sulfur, Hh1 is optionally substituted by R15, and is a bisheteroaryl radical made up of two heteroaryl groups, which are independently selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, and which are linked together via a single bond, in which R15 is 1-4C-alkyl, Ah1 is optionally substituted by R16, and is an arylheteroaryl radical made up of an aryl group selected from the group consisting of phenyl and naphthyl, and a heteroaryl group selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, whereby said aryl and heteroaryl groups are linked together via a single bond, in which R16 is 1-4C-alkyl, Ha1 is optionally substituted by R17, and is a heteroarylaryl radical made up of a heteroaryl group selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, and an aryl group selected from the group consisting of phenyl and naphthyl, whereby said heteroaryl and aryl groups are linked together via a single bond, in which R17 is 1-4C-alkyl, whereby each of the radicals Har1, Har2, Har3, Hh1 and Ah1 is bonded via a ring carbon atom to the pyrazolopyrimidine scaffold; R2 is hydrogen, halogen or 1-4C-alkyl; R3 is -T-R30, —U—Ar2, —V—Har4, or Cyc2, in which T is 1-4C-alkylene, R30 is —N(R301)R302, cyano, amidino, carbamoyl, guanidino, ureido, 1-4C-alkylsulfonyl, or Het2, in which R301 is hydrogen, 1-4C-alkyl, 1-4C-alkoxycarbonyl, hydroxy-2-4C-alkyl or 1-4C-alkoxy-2-4C-alkyl, R302 is hydrogen or 1-4C-alkyl, or R301 and R302 together and with inclusion of the nitrogen atom to which they are bonded form a radical Het1, in which Het1 is a monocylic 3- to 7-membered saturated heterocyclic ring comprising the nitrogen atom, to which R301 and R302 are attached, and optionally one further heteroatom selected from the group consisting of oxygen, nitrogen, N(R303) and sulfur, in which R303 is hydrogen, 1-4C-alkyl or 1-4C-alkoxycarbonyl, Het2 is a monocylic 3- to 7-membered saturated heterocyclic ring, R304 is 1-4C-alkyl, U is a bond, 1-4C-alkylene, or 1-4C-alkylene substituted with amino-1-4C-alkyl, Ar2 is phenyl, or R31- and /or R32-substituted phenyl, in which R31 is 1-4C-alkyl, 1-4C-alkoxy, halogen, trifluoromethyl, or —W—R311, in which W is a bond or 1-4C-alkylene, R311 has one of the meanings of R30 as defined above, R32 is halogen, V is a bond, Har4 is optionally substituted by R33, and is a monocyclic or fused bicyclic 5- to 10-membered unsaturated heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, whereby said Har4 radical is attached to the moiety V via a ring carbon atom, in which R33 is -Z-R331, in which Z is 1-4C-alkylene, R331 has one of the meanings of —N(R301)R302 as defined above, Cyc2 is a group of formula A in which G is a 5- or 6-membered saturated heterocyclic ring comprising one nitrogen atom and optionally one further heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, R4 is hydrogen or halogen; or a salt thereof.