Patent ID: 9220676
Filing Date: 2015-12-29
Classification: A61K,A61L,A61P,C08J

Abstract:
1. A method of preparing an injectable in-situ crosslinked hydrogel, comprising: (1) filling a crosslinking active solution into an injectable container, wherein the crosslinking active solution contains at least one biocompatible macromolecule with more than two thiol groups on side chains; (2) sealing the injectable container containing the crosslinking active solution; and (3) oxidizing the thiol groups into disulfide bonds to form the crosslinked hydrogel by oxygen dissolved in the crosslinking active solution in the sealed injectable container; wherein, crosslinking occurs in-situ in the sealed injectable container; and wherein, the time taken for the crosslinking active solution to gradually form a disulfide-bond crosslinked hydrogel in the injectable container is longer than 30 minutes.