Patent ID: 6943033
Filing Date: 2005-09-13
Classification: G01R,Y10T

Abstract:
1. The method for claim determining an effect of amide proton transfer between amide protons of endogenous mobile proteins/peptides and water protons as measured by one or MRI or NMR spectroscopy or spectroscopic imaging, said effect being reflected in one of amide proton content, amide proton exchange properties or mobile protein/peptide content, said method comprising the steps of: irradiating a pool of amide protons of said mobile protons and peptides that is in exchange with a pool of water protons to label the amide protons of said pool of amide protons and measuring the effect on the water protons; determining an amide proton transfer (APT) effect corresponding to the transfer of saturation between said pool of amide protons and said pool of water protons; and determining change in or difference between one of labile amide proton content, pH or pH effects from the determined amide proton transfer effect between spatial areas, tissues and the like being subjected to said irradiation.