Patent ID: 6403346
Filing Date: 2002-06-11
Classification: C07B,C07C,C07F,C12P,Y02P

Abstract:
A process for preparing a compound of the formula: wherein R3 is lower alkyl or mono-chlorinated lower alkyl; which comprises: a) protecting the hydroxy groups of the trans/cis/trans compound of the formula: or protecting the hydroxy groups of the all cis 1,3,5-trihydroxycyclohexane, to obtain the compound of the formula: wherein R3 is lower alkyl or mono-chlorinated lower alkyl), or in the case of the all cis 1,3,5-trihydroxycyclohexane, obtaining the protected all cis 1,3,5-trihydroxycyclohexane wherein the hydrogen atoms of the hydroxy groups have been replaced by R3 as above; b) hydrolyzing the R3CO-group in the 5-position in a biphasic water/organic solvent system in an enzymatic reaction to obtain a product of formula (2): wherein R3 is as above; and c) oxidizing the hydroxy group to obtain a compound of formula Ia.