Patent ID: 9080184
Filing Date: 2015-07-14
Classification: C07H,C12N

Abstract:
1. A transgenic in vitro mesenchymal stem cell, said stem cell comprising a transiently expressed exogenous polynucleotide sequence encoding G-CSF (granulocyte colony-stimulating factor) introduced into said stem cell from adenovirus or a plasmid comprising said polynucleotide sequence encoding G-CSF, said mesenchymal stem cell having a doubling time of about 23 hours under hypoxic conditions wherein said mesenchymal stem cell is positive for CD13, CD29, CD73, CD81, CD90, CD105, CD164 and CD166, and negative for CD14, CD19, CD34, CD45, CD122 and HLA-DR wherein said transgenic cell is derived from mesenchymal stem cells obtained from bone marrow and grown under low oxygen conditions.