Patent ID: 9072592
Filing Date: 2015-07-07
Classification: A61F,A61L,D01D,D01F

Abstract:
1. A method for producing silk nanofiber nerve conduit, the method comprising: preparing fibrous spinning solution (Step 1); the preparing comprising: producing a silk nanofiber having a diameter of 200-400 nm and stacked layer-upon-layer to form a porous conduit shape having a thickness of 0.1-0.3 mm by electrospinning at 100-300 rpm the fibrous spinning solution prepared in step 1 into a cylindrical collecting part coated with polyethyleneoxide (PEO) (Step 2) until an outer diameter of the porous conduit shape is 2.0 to 2.1 mm; and submerging the collecting part in methanol or ethanol to insolubilize the silk nanofiber; submerging in water for separation and separating the silk nanofiber of conduit-shape produced in step 2 from the collecting part, thereby forming the silk nanofiber nerve conduit, wherein the outer diameter of the collected silk nanofiber nerve conduit is 2.0-2.1 mm and the size of the pores formed on the silk nanofiber nerve conduit is between 50 and 250 μm (Step 3).