Patent ID: 6197793
Filing Date: 2001-03-06
Classification: A61P,C07D

Abstract:
A compound of Formula (I) ##STR11##in which:A.sub.1 and A.sub.2 independently from each other denote a group Z-(CH.sub.2).sub.k --(NR'"").sub.q, wherein Z is a 4-10 membered mono- or bicyclic heterocyclic ring system containing up to four heteroatoms N, O, S in the ring in which at least one heteroatom is N, and wherein the ring is substituted or unsubstituted by one or two C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.4, oxo, oxime, O-C.sub.1-4 alkyloxime, hydroxy, N(R.sub.3).sub.2, acylarnino or aminoacyl groups, 8, 9, 10 membered monocyclic ring systems being excluded;R' and R"" are independently hydrogen, C.sub.1-4 alkylC(O)R.sub.4, C.sub.1-4 alkyl or R' and R"" are benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sub.3).sub.2 ;k is an integer from 0 to 4;R'"" denotes Hydrogen, C.sub.1-4 -alkyl or C.sub.1-4 -alkylcarboxylic acid;q is an integer from 0 to 1;Q denotes a group ##STR12##wherein:B.sub.1 denotes halogen, --(CH.sub.2).sub.m --CN, --(CH.sub.2).sub.m+1 --R.sup.2, --(CH.sub.2).sub.m --R.sup.3, --(CH.sub.2).sub.m --COR.sup.2 or --(CH.sub.2).sub.m --COR.sup.3 ; whereR.sup.2 denotes --OR.sup.3, --N(R.sup.3).sub.2, --SR.sup.3 ;R.sup.3 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;m is an integer from 0 to 4;C.sub.1 denotes halogen, --(CH.sub.2).sub.n --CN, --(CH.sub.2).sub.n+1 -R.sup.4, --(CH.sub.2).sub.n --R.sup.5, --(CH.sub.2).sub.n --COR.sup.4 or --(CH.sub.2).sub.n --COR.sup.5 ;R.sup.4 is independently --OR.sup.5, --N(R.sup.5).sub.2, --SR.sup.5 ;R.sup.5 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl and n is an integer from 0to 4;B.sub.2 denotes halogen, --(CH.sub.2).sub.p --CN, --(CH.sub.2).sub.p+1 --R.sup.6, --(CH.sub.2).sub.p --R.sup.7, --(CH.sub.2).sub.p -COR.sup.6 or -(CH.sub.2).sub.p -COR.sup.7 ;R.sup.6 is independently -OR.sup.7, -N(R.sup.7).sub.2, -SR.sup.7 ;R.sup.7 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;p is independently an integer from 0 to 4;C.sub.2 denotes halogen, -(CH.sub.2).sub.1 -CN, -(CH.sub.2).sub.1+1 -R.sup.8, -(CH.sub.2).sub.1 -R.sup.9, -(CH.sub.2).sub.1 -COR.sup.8 or -(CH.sub.2).sub.1 -COR.sup.9 ;R.sup.8 is independently -OR.sup.9, -N(R.sup.9).sub.2, -SR.sup.9,R.sup.9 is independently hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl;l is an integer from 0 to 4;D denotes -(CH.sub.2).sub.x -E-(CH.sub.2).sub.y -; whereinE denotes a mono- or bicyclic aromatic or nonaromatic ring system consisting of 5-10 carbon atoms containing up to 4 heteroatoms N, O or S in the ring, which is optionally mono-, poly or mixed substituted by alkyl, alkoxy, oxo, alkoxyalky, hydroxy, amino or dialkylamino and x and y independently denote an integer from 0 to 5; with the proviso thatA.sub.1 A.sub.2 ;B.sub.1 B.sub.2 ;C.sub.1 C.sub.2 ;B.sub.1 C.sub.1 ; andB.sub.2 C.sub.2 ;and pharmaceutically acceptable salts thereof.