Patent ID: 8957082
Filing Date: 2015-02-17
Classification: A61K,A61P,C07D

Abstract:
1. A method of treatment of a disease or condition by inhibiting human neutrophil elastase (HNE), comprising administering to a subject suffering such disease or condition an effective amount of a compound comprising two, three or four molecules, covalently linked through a linker framework, wherein the molecules have formula (I): wherein A is selected from the group consisting of aryl and heteroaryl; D is selected from the group consisting of oxygen and sulphur; R R and R k, m, n, p and q are independently selected from 0 and 1; Alk Q represents (i) —O—, —S—, —S(═O)—, —S(═O) X is —(C═O)—, —S(O R X Z is hydrogen or an optionally substituted mono- or bicyclic carbocyclic or heterocyclic group having 3-6 ring members, and pharmaceutically acceptable salts thereof, and wherein the disease or condition is selected from the group consisting of chronic obstructive pulmonary disease, chronic bronchitis, lung fibrosis, pneumonia, acute respiratory distress syndrome, pulmonary emphysema, smoking-induced emphysema, asthma and cystic fibrosis.