Patent ID: 6538114
Filing Date: 2003-03-25
Classification: A61K,A61P,C07K

Abstract:
A recombinant human monoclonal antibody that exhibits immunological binding affinity for a hepatitis C virus (HCV) E2 antigen, wherein the antibody comprises a Fab molecule that comprises an HCV E2 antigen binding portion of a human &ggr;1 heavy chain variable region (VH) and an HCV E2 antigen binding portion of a human &kgr; light chain variable region (VL), and further wherein the VH region is selected from the group consisting of the contiguous sequence of amino acids depicted in FIG. 1A (SEQ ID NO: 1) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, the contiguous sequence of amino acids depicted in FIG. 1B (SEQ ID NO: 2) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, the contiguous sequence of amino acids depicted in FIG. 1C (SEQ ID NO: 3) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, and the contiguous sequence of amino acids depicted in FIG. 1D (SEQ ID NO: 4) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, and/or the VL region is selected from the group consisting of the contiguous sequence of amino acids depicted in FIG. 2A (SEQ ID NO: 5) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, the contiguous sequence of amino acids depicted in FIG. 2B (SEQ ID NO: 6) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, the contiguous sequence of amino acids depicted in FIG. 2C (SEQ ID NO: 7) or a contiguous sequence of amino acids with at least 90% sequence identity thereto, and the contiguous sequence of amino acids depicted in FIG. 2D (SEQ ID NO: 8) or a contiguous sequence of amino acids with at least 90% sequence identity thereto.