Patent ID: 7824679
Filing Date: 2010-11-02
Classification: A61P,C07K

Abstract:
1. A human monoclonal antibody or an antigen-binding portion thereof that specifically binds to CTLA-4, wherein said antibody comprises heavy chain CDR1, CDR2, and CDR3 amino acid sequences from a heavy chain variable domain; and wherein said antibody comprises light chain CDR1, CDR2, and CDR3 amino acid sequences from a light chain variable domain; wherein said heavy chain variable domain and said light chain variable domain comprise: (a) the amino acid sequence of SEQ ID NO: 73 and the amino acid sequence of SEQ ID NO: 95, respectively; (b) the amino acid sequence of SEQ ID NO: 75 and the amino acid sequence of SEQ ID NO: 89, respectively; (c) the amino acid sequence of SEQ ID NO: 76 and the amino acid sequence of SEQ ID NO: 92, respectively; (d) the amino acid sequence of SEQ ID NO: 78 and the amino acid sequence of SEQ ID NO: 90, respectively; (e) the amino acid sequence of SEQ ID NO: 79 and the amino acid sequence of SEQ ID NO: 91, respectively; (f) the amino acid sequence of SEQ ID NO: 81 and the amino acid sequence of SEQ ID NO: 97, respectively; (g) the amino acid sequence of SEQ ID NO: 82 and the amino acid sequence of SEQ ID NO: 98, respectively; (h) the amino acid sequence of SEQ ID NO: 83 and the amino acid sequence of SEQ ID NO: 114, respectively; or (i) the amino acid sequence of SEQ ID NO: 84 and the amino acid sequence of SEQ ID NO: 116, respectively.