Patent ID: 6300341
Filing Date: 2001-10-09
Classification: A61P,C07D

Abstract:
A compound having a structure: ##STR66##and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein:(a) G is selected from the group consisting of alkyl having at least 3 carbon atoms, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, and heteroarylalkenyl;(b) Z is a saturated or unsaturated 4-, 5-, 6-, 7-, 8-, or 9-membered heterocycle optionally containing one or more additional heteroatoms selected from the group consisting of O, N, S, S(O), S(O).sub.2, and P((O)OK);(c) K is selected from the group consisting of hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, and heteroarylalkenyl;(d) W is selected from the group consisting of nil, hydrogen, and lower alkyl;(e) A is selected from the group consisting of nil and alkyl;(f) Y is selected from the group consisting of N, O, and S;(g) R.sub.2 and R.sub.3 are each, independently, selected from the group consisting of nil, hydrogen, alkyl, and arylalkyl;(h) R.sub.4 is selected from the group consisting of methylene and methyne;(i) R.sub.5 and R.sub.6 are each, independently, selected from the group consisting of nil, hydrogen, alkyl having at least three carbon atoms, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, and heteroarylalkenyl; or wherein R.sub.5 and R.sub.6 are bonded together to form a carbocyclic or hetercyclic ring; wherein at least one of R.sub.5 or R.sub.6 is not nil or hydrogen;(j) Q is selected from the group consisting of CH.sub.2, CHR.sub.9, NR.sub.9, S, S(O), and S(O).sub.2 ;(k) R.sub.9 and R.sub.10 are each, independently, selected from the group consisting of nil, hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, halo, cyano, hydroxy, oxo, imino, --R.sub.14 SR.sub.15, --R.sub.14 S(O.sub.2)R.sub.15, --R.sub.14 S(O)R.sub.15, --R.sub.14 C(O)R.sub.15, --R.sub.14 C(O)NR.sub.15 R.sub.16, --R.sub.14 C(O)OR.sub.15, --R.sub.14 OR.sub.15, --R.sub.14 NR.sub.15 R.sub.16, --R.sub.14 P(O)NR.sub.15 R.sub.16, --R.sub.14 P(O)OR.sub.15 R.sub.16, and a spiro moiety;(l) R.sub.7 and R.sub.8 are bonded together to form an aromatic or saturated, carbocyclic or heterocyclic ring wherein the ring is fused to Z;(m) R.sub.14 is selected from the group consisting of nil, alkyl, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, and heteroarylalkenyl;(n) R.sub.15 is selected from the group consisting of hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroarylalkyl, arylalkenyl, and heteroarylalkenyl; and(o) R.sub.16 is selected from the group consisting of hydrogen and alkyl.