Patent ID: 8937080
Filing Date: 2015-01-20
Classification: A61K,A61P,C07D,C07K,Y02A

Abstract:
1. A compound of the formula I: wherein: A is —C(═O)OR R R X is N, CH and when X bears a double bond it is C; R E is NR R n is 3, 4, 5 or 6; each dotted line ----- independently represents an optional double bond; each aryl independently is phenyl optionally substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, carboxyl, C each Het independently is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms each independently selected from nitrogen, oxygen and sulfur, said heterocyclic ring being optionally substituted with one, two or three substituents each independently selected from halo, hydroxy, nitro, cyano, carboxyl, C each Het wherein the pyrimidinyl radical wherein R 7 and R 8 independently are phenyl or C 1-6 alkoxy; R each R or a stereoisomer, N-oxide or pharmaceutically acceptable addition salt thereof.