Patent ID: 7524939
Filing Date: 2009-04-28
Classification: C07K,C12N,G01N

Abstract:
1. A monoclonal antibody that competes with a monoclonal antibody MAb 763-15-5 for specific binding to the human cytochrome p450 2C9 allelic variants 2C9*1, 2C9*2, and 2C9*3 at the same epitope bound by the monoclonal antibody MAb 763-15-5, wherein the MAb 763-15-5 inhibits 2C9*1 catalyzed metabolism of phenanthrene and 2C9*2 catalyzed metabolism of phenanthrene, wherein binding between the monoclonal antibody MAb 763-15-5 and the human cytochrome p450 2C9 allelic variants 2C9*1, 2C9*2, and 2C9*3 is detectable by an enzyme-linked immunosorbent assay, and wherein MAb 763-15-5 is produced by the hybridoma cell line deposited as ATCC PTA-1079, and wherein the light chain variable domain of the monoclonal antibody that competes with MAb 763-15-5 comprises the three CDR regions from the light chain of the monoclonal antibody MAb 763-15-5 (ATCC PTA-1079), and the heavy chain variable domain of the monoclonal antibody that competes with MAb 763-15-5 comprises the three CDR regions from the heavy chain of the monoclonal antibody MAb 763-15-5 (ATCC PTA-1079).