Patent ID: 8906872
Filing Date: 2014-12-09
Classification: A61P,C07K,C12N

Abstract:
1. A method of inhibiting replication of a Coronavirus in a mammalian host cell, comprising administering to the infected mammalian host cells, a virus-inhibitory amount of an oligonucleotide analog coumpound characterized by: (i) a nuclease-resistant backbone, (ii) capable of uptake by mammalian host cells, (iii) containing between 12-40 nucleotide bases, and (iv) having a targeting sequence of at least 12 subunits that is complementary to a region associated with stem-loop secondary structure within the 5′-terminal end 40 bases of the positive sense RNA strand of the by said administering, forming within the infected mammalian host cell, a heteroduplex structure (i) composed of the positive-sense RNA strand of the