Patent ID: 6451587
Filing Date: 2002-09-17
Classification: C12P

Abstract:
A process for the microbial asymmetric reduction of a compound of Formula A to the compounds of Formulae B and C which comprises:contacting an amount of said compound of Formula A with a microorganism selected from the group consisting of: Rhodococcus sp. ATCC No. 15592, Rhodococcus globerulus ATCC No. 21505, Geotrichum candidum ATCC No. 7341, Mucor ambiguus IFO 06742, Zygosaccharomyces bailii ATCC No. 38924, Zygosaccharomyces bailii PTA-660, Rhodotorula mucilaginosa v. mucilaginosa ATCC No. 90687, Rhodotorula mucilaginosa ATCC No. 04056, Rhodotorula mucilaginosa v. mucilaginosa ATCC No. 36307, Rhodotorula mucilaginosa v. mucilaginosa ATCC No. 4558, and any mutants thereof capable of accomplishing said reduction; incubating the resulting mixture under conditions sufficient to yield at least about a 60% enantiomeric excess of said compound of Formula B; and recovering said compound of Formula B.