Patent ID: 7939250
Filing Date: 2011-05-10
Classification: A01K,C07K,C12N,C12Q,C12Y

Abstract:
1. A method of diagnosing warfarin resistance in a patient comprising the steps of: (I) amplifying a DNA sample obtained from the patient or reverse transcribing an RNA sample obtained from the patient into a DNA and amplifying the DNA; and (II) analyzing the amplified DNA of step (I) to determine at least one sequence mutation in an amino acid sequence of the vitamin K epoxide recycling (VKORC1) polypeptide as compared to the VKORC1 sequence set forth in SEQ ID NO: 1 wherein the presence of a mutation in the sequence of SEQ ID NO: 1 in the VKORC1 protein of said patient is indicative of the patient being warfarin resistant; wherein said mutation in the amino acid sequence set forth in SEQ ID NO: 1 is selected from the group consisting of V29L, R98W, and Y139C.