Patent ID: 9151752
Filing Date: 2015-10-06
Classification: G01N

Abstract:
1. A method for amplifying frequency variation of a detected signal in a biomolecule detecting biosensor, the method comprising the steps of: (a) applying a metal particle to a sample to allow a biomolecule in the sample to be tagged with the metal particle: (b) applying the sample containing the biomolecule tagged with the metal particle to a probe which is fixed to an upper portion of a substrate of the biosensor to allow the biomolecule in the sample to be bound to the probe; and (c) washing the surface of the biosensor with buffer solution which does not contain salt capable of producing a precipitate or which contains low-concentration salt; and (d) applying a metal enhancer to the biosensor to allow the metal enhancer to be bound to the metal particles which is bound to the biomolecule.