Patent ID: 8101565
Filing Date: 2012-01-24
Classification: A61F,A61K,A61L,A61M,C07K

Abstract:
1. A composition, comprising: an apolipoprotcin A-I (apo A-I) synthetic mimetic peptide complexed with phospholipid, wherein the apo A-I synthetic mimetic peptide comprises an amino acid sequence or, a C-terminal or N-terminal derivatized amino acid sequence selected from the group consisting of: (i) an 18-mer synthetic peptide comprising DWLKAFYDKVAEKLKEAF (SEQ ID NO: 2); (ii) a 33-mer synthetic peptide comprising PALEDLRQGLLPVLESFKVFLSALEEYTKKLNTQ (SEQ ID NO: 3); (iii) a 1/9 chimera of endogenous apo A-I wherein “1” is alpha helix 1 and “9” is alpha helix 9 of endogenous apo A-I; and reverse sequences of each of (i) through (iii) thereof; and a carrier associated with the apo A-I synthetic mimetic peptide wherein the carrier is selected from the group consisting of a liposome, a polymerosomc, a micelle, a particle, a gel, a microbubble, a precipitated peptide particle, a porous glass particle, and a rod.