Patent ID: 7026465
Filing Date: 2006-04-11
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid encoding a fusion polypeptide comprising the MTB32A antigen and the MTB39 antigen from a Mycobacterium species of the tuberculosis complex, wherein said nucleic acid hybridizes under highly stringent conditions to a nucleic acid comprising a nucleotide sequence of SEQ ID NO:1 or the complement thereof, and wherein the MTB32A antigen has a mutation at amino acid position 183 as compared to wild type MTB32A, wherein the highly stringent conditions comprise incubation in 50% formamide, 5×SSC, and 1% SDS at 42° C., or incubation in 5×SSC and 1% SDS at 65° C., with wash in 0.2×SSC and 0.1% SDS at 65° C.