Patent ID: 6716842
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:X is a tether 2 to 5 atoms in length, wherein 0, 1, 2, or 3 of the atoms of the tether are O, S, or NR1, wherein R1 is H or (C1-C6)alkyl, and wherein the other atoms are CR2R3, CR4&boxH;CR5, or Câ‰¡C, wherein R2 and R3 taken together are &boxH;O, or R2-R5 are each independently H or (C1-C6)alkyl; E is COR6, wherein R6 is (C1-C6)alkyl, OH, (C1-C6)alkoxy, NR7R8, wherein R7 and R8 are each independently H or (C1-C6)alkyl, or one of R7 and R8 is H or (C1-C6)alkyl and the other is SO2R9, wherein R9 is H or (C1-C6)alkyl, or E is substituted heteroaryl or Râ€² is H, C1-C7 alkyl and substituted alkyl, C2-C7 alkenyl and substituted alkenyl, C2-C7 alkynyl and substituted alkynyl, C3-C7 cycloalkyl and substituted cycloalkyl, aryl and substituted aryl, heterocyclic and substituted heterocyclic, heteroaryl and substituted heteroaryl, halo, NO2, NO, CN, ORa, â€ƒwherein Ra is H, C1-C7 alkyl and substituted alkyl, C2-C7 alkenyl and substituted alkenyl, C3-C7 cycloalkyl and substituted cycloalkyl, aryl and substituted aryl, heteroaryl and substituted heteroaryl, or heterocycloalkyl and substituted heterocycloalkyl.