Patent ID: 6403308
Filing Date: 2002-06-11
Classification: A01N,A61K,C07K

Abstract:
A purified and isolated nucleic acid molecule, extracted from a nematode, encoding a P-glycoprotein which regulates resistance to a macrocyclic lactone compound, wherein the nucleic acid molecule has a nucleotide sequence which exhibits an allelic pattern consistent with the nucleotide sequence encoding PGP-A set forth in SEQ ID NO:3, PGP-A-3â€² set forth in SEQ ID NO:5 (ATCC accession number 98336), PGP-B, PGP-B-3â€² set forth in SEQ ID NO:8 (ATCC accession number 98307), PGP-O or PGP-O-3â€² set forth in SEQ ID NO:7 (ATCC accession number 98309); the complementary strands thereof or a nucleotide sequence which hybridizes at about 65 degrees in the presence of a dextran buffer over at least about 4 hours to the nucleotide sequence encoding PGP-A, PGP-A-3â€², PGP-B, PBP-B-3â€², PGP-O or PGP-O-3â€².