Patent ID: 7988970
Filing Date: 2011-08-02
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a disease or disorder selected from the group consisting of osteoporosis, osteopenia, osteoarthritis, and pain associated with osteoarthritis in a human subject in need thereof, comprising administering to said human subject an effective amount of an antibody or antigen-binding portion thereof, that binds human sclerostin and comprises a heavy chain variable region and a light chain variable region, wherein: i) the heavy chain variable region has the amino acid sequence of SEQ ID NO: 14, and the light chain variable region has the amino acid sequence of SEQ ID NO: 17; or ii) the heavy chain variable region has the amino acid sequence of SEQ ID NO: 15, and the light chain variable region has the amino acid sequence of SEQ ID NO: 18.