Patent ID: 6677164
Filing Date: 2004-01-13
Classification: A61K,C07K,C08G,Y10S

Abstract:
A linear polypeptide comprising at least two structural elements of the formula whereineach A is independently a trivalent, aliphatic hydrocarbon radical having from 1 to 12 carbon atoms which is unsubstituted or substituted by one or more substituents selected from the group consisting of C1-C4-alkyl, C1-C4alkoxy, C1-C4alkylthio, benzyl and benzyloxy; each R1 is independently a direct bond or C1-C6alkylene; each X1 is independently â€”C(O)Oâ€”,â€”C(O)NRâ€”, â€”NRâ€”, â€”Sâ€” or â€”Oâ€”; each R2 is independently a bivalent bridging group; each X2 is independently O or NR; or independently, each R2 and X2 are together a direct bond; and each R is independently H or C1-C6alkyl; with the proviso that X1 is not â€”NRâ€”, â€”Sâ€” or â€”Oâ€” when R1 is a direct bond; and each R3 is independently a biological active group which is covalently bound to the S atom either directly or by way of a bridging group Y, wherein at least one R3 is different from another R3.