Patent ID: 6818435
Filing Date: 2004-11-16
Classification: A63B,B01F,B01L,G01N,Y10T

Abstract:
A centripetally-motivated microsystems platform comprising:a) a rotatable platform comprising a substrate having a surface comprising a one or a multiplicity of microfluidics structures embedded in the surface of the platform, wherein each microfluidics structure comprises i) a distribution manifold, i) one or a plurality of cell culture chambers adapted or treated to permit cell attachment and growth, and ii) one or a plurality of overflow reservoirs wherein each of said cell culture chambers is fluidly connected to the distribution manifold and to at least one of the plurality of overflow reservoirs microchannels, and wherein the platform further comprisesb) a distribution manifold overflow reservoir, wherein the overflow reservoir is fluidly connected to the distribution manifold by a microchannel that makes a fluid connection with the distribution manifold at a position on the manifold proximal to the axis of rotation, and wherein fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.