Patent ID: 6599902
Filing Date: 2003-07-29
Classification: A61P,C07D

Abstract:
A compound of Formula (I): wherein:n is 0,1, or 2; m is 1,2, or 3; R1 and R2 are independently hydrogen or alkyl; R3, R4, and R5 are independently hydrogen, halo, alkyl, cycloalkyl, haloalkyl, hydroxy, alkoxy, alkoxycarbonyl, haloalkoxy, cyano, carboxy, carboxyalkyl, nitro, aryl, aryloxy, heteroaryl, heteroaryloxy, â€”(alkylene)â€”CONR10R11, â€”CONR10R11, or â€”NR10R11, (where R10 is hydrogen or alkyl, and R11 is aryl, heteroaryl, heterocycle, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, acetylalkyl, cyanoalkyl, carboxyalkyl, alkoxycarbonylalkyl, heteroaralkyl, aralkyl, or heterocyclylalkyl wherein the alkyl chain in aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkyl, heteroaralkyl, or heterocyclylalkyl is optionally substituted with one or two hydroxy, or R10 and R11 together with the nitrogen atom to which they are attached combine to form saturated or unsaturated heterocycloamino); R6 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, heterocyclylalkyl, aryl, heteroaryl, carboxy, alkoxycarbonyl, heterocyclylcarbonyl, aminoalkylcarbonyl, alkylaminoalkylcarbonyl, dialkylaminoalkylcarbonyl, â€”CONR10R11 or â€”(alkylene)â€”CONR10R11 (where R10 is hydrogen or alkyl, and R11 is aryl, heteroaryl, heterocycle, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, acetylalkyl, cyanoalkyl, carboxyalkyl, alkoxycarbonylalkyl, heteroaralkyl, aralkyl, or heterocyclylalkyl wherein the alkyl chain in aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkyl, heteroaralkyl, or heterocyclylalkyl is optionally substituted with one or two hydroxy or R10 and R11 together with the nitrogen atom to which they are attached combine to form saturated or unsaturated heterocycloamino); R7 and R8 are independently hydrogen, alkyl, cycloalkyl, heterocyclylalkyl, â€”COR12, â€”(alkylene)â€”COR12 (where R12 is alkoxy, hydroxy, or heterocyle, alkylamino, dialkylamino), â€”SO2R14, â€”CONR13R14, or â€”(alkylene)â€”CONR13R14 (where R13 is hydrogen or alkyl, and R14 is aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, acetylalkyl, cyanoalkyl, carboxyalkyl, alkoxycarbonylalkyl, heteroaralkyl, or heterocyclylalkyl wherein the alkyl chain in aminoalkyl, heteroaralkyl, heteroaralkyl, or heterocyclylalkyl is optionally substituted with one or two hydroxy group(s), or when R13 and R14 are attached to a nitrogen atom R13 and R14 together with the nitrogen atom to which they are attached form saturated or unsaturated heterocycloamino); R6 and R7 or R7 and R8 can combine to form a saturated or unstaturated 5 to 8 membered ring; and R9 is: (a) hydrogen or alkyl; (b) â€”PO(OR15)2 where each R15 is independently hydrogen or alkyl; (c) â€”COR16 where R16 is hydrogen or alkyl; or (d) â€”CHR17NR18R19 where R17 is hydrogen or alkyl, and R18 and R19 are independently hydrogen or alkyl or R18 and R19 together with the nitrogen atom to which they are attached form heterocycloamino; or a pharmaceutically acceptable salt thereof.