Patent ID: 6239178
Filing Date: 2001-05-29
Classification: A61K

Abstract:
A method for reducing symptoms of a headache in a mammal, which method comprises the step of reducing the concentration of arginine in the blood of the mammal and its arteries by administering to the mammal an inhibitor of an enzyme which leads to an increase in nitric oxide levels, wherein the enzyme is arginosuccinase and the inhibitor of arginosuccinase is a N3 or N2 and N3 substituted arginine, or a mixture thereof, wherein the N3 or N2 and N3 substituted arginine is selected from the group consisting of:N3-(1-carboxy-2-methoxycarbonyl-ethyl)-L-arginine;N3-(1-carboxy-2-propoxycarbonyl-ethyl)-L-arginine;N3-(1-carboxy-2-isobutoxycarbonyl-ethyl)-L-arginine;N3-(1-carboxy-3-N-ethylpropanamide)-L-arginine;N3-(1,2-dimethoxycarbonyl-ethyl)-L-arginine;N3-(2-carboxy-1-methoxycarbonyl-ethyl)-L-arginine;N3-(2-carboxy-1-propoxycarbonyl-ethyl)-L-arginine;N3-(2-carboxy-2-isobutoxycarbonyl-ethyl)-L-arginine;N3-(2-carboxy-1-N-ethylmethamide-ethyl)-L-arginineN3-(1-carboxy-2-nitroethyl)-L-arginine;N2-methyl-N3-(L-1,2-dicarboxy-ethyl)-L-arginine;N2-dimethyl-N3-(1,2-dicarboxy-ethyl)-L-arginine;N2-propyl-N3-(1,2-dicarboxy-ethyl)-L-arginine;N2-isobutyl-N3-1,2-dicarboxy-ethyl)-L-arginine; andN2-ethylamino-N3-(1,2-dicarboxy-ethyl)-L-arginine.