Patent ID: 7534589
Filing Date: 2009-05-19
Classification: C08B,C12P

Abstract:
1. A method for elongating a functional acceptor, comprising the steps of: providing a functional acceptor, wherein the functional acceptor has at least two sugar units selected from the group consisting of GlcUA, GlcNAc, GalNAc, and hexosamine, and wherein the functional acceptor is attached to a substrate selected from the group consisting of silica, silicon, glass, polymers, organic compounds, metals and combinations thereof; providing a recombinant, soluble hyaluronic acid synthase having an empty acceptor site and being capable of elongating the functional acceptor, wherein the recombinant, soluble hyaluronic acid synthase has the amino acid sequence as set forth in SEQ ID NO:1; and providing UDP-GlcUA and UDP-GlcNAc sugars such that the recombinant, soluble hyaluronic acid synthase elongates the functional acceptor.