Patent ID: 6506874
Filing Date: 2003-01-14
Classification: A61K,A61P,C07K

Abstract:
An IGF-I variant(a) wherein an amino acid residue located at a single position selected from the group consisting of positions 4, 5, 7, 10, 14, 17, 23, 24, and 43 of native-sequence human IGF-I (SEQ ID NO:1) is replaced with an alanine residue, or (b) wherein both amino acid residues at positions 1 and 70 of native-sequence human IGF-I (SEQ ID NO:1) are replaced with a serine residue and a valine residue, respectively, or (c) wherein both amino acid residues at positions 1 and 70 of native-sequence human IGF-I (SEQ ID NO:1) are replaced with a serine residue and a valine residue, respectively, and an amino acid residue located at a single position selected from the group consisting of positions 3, 4, 5, 7, 10, 14, 17, 23, 24, 25, and 43 of native-sequence human IGF-I is replaced with an alanine residue.