Patent ID: 6815437
Filing Date: 2004-11-09
Classification: A61K,A61P,C07K

Abstract:
A group A streptogramin derivative chosen from group A streptogramin derivatives of formula (I), salts thereof, and mixtures of stereoisomers of any of the foregoing: wherein:R1 is chosen from â€”NRâ€²Râ€³ groups, wherein Râ€² is chosen from a hydrogen atom and a methyl group, and Râ€³ is chosen from (i) a hydrogen atom, (ii) alkyl groups, (iii) cycloalkyl groups, (iv) an allyl group, (v) a propynyl group, (vi) a benzyl group, (vii) â€”ORâ€²â€³ groups, wherein Râ€²â€³ is chosen from a hydrogen atom, alkyl groups, cycloalkyl groups, an allyl group, a propynyl group, and a benzyl group, and (viii) â€”NR3R4 groups, wherein R3 and R4 are each a methyl group, or R3 and R4, which are identical or different, form, together with the nitrogen atom to which they are attached, a saturated or unsaturated 4- to 5-membered heterocyclyl group, wherein one of said members, in addition to said nitrogen atom, may be an atom chosen from an oxygen atom, a sulphur atom; and a nitrogen atom, R2 is chosen from a hydrogen atom, a methyl group, and an ethyl group, the bond  is a single bond or a double bond, unless otherwise stated, said alkyl groups are chosen from straight and branched C1-C6 alkyl groups, unless otherwise stated, said cycloalkyl groups are chosen from C3-C4 cycloalkyl groups, when said Râ€³ is chosen from a hydrogen atom, alkyl groups, cycloalkyl groups, an allyl group, a propynyl group, and a benzyl group: said group A streptogramin derivatives are chosen such that the carbon bearing said R1 is of the R configuration, said salts are chosen such that the carbon bearing said R1 is of the R configuration, and said mixtures are chosen such that said mixtures comprise at least one stereoisomer, wherein the carbon bearing said R1 is of the R configuration, and at least one stereoisomer, wherein the carbon bearing said R1 is of the S configuration, and wherein said R configuration is predominant, and when Râ€³ is chosen from said â€”ORâ€²â€³ groups and said â€”NR3R4 groups: said group A streptogramin derivatives are chosen such that the carbon bearing said R1 is of the R configuration or the S configuration, said salts are chosen such that the carbon bearing said R1 is of the R configuration or the S configuration, and said mixtures are chosen such that said mixtures comprise at least one stereoisomer, wherein the carbon bearing said R1 is of the R configuration, and at least one stereoisomer, wherein the carbon bearing said R1 is of the S configuration.