Patent ID: 6130340
Filing Date: 2000-10-10
Classification: C07B,C07D

Abstract:
A process of stereoselective chemical synthesis which comprises reacting a dienophile and a 1,3-diene in the presence of a non-racemic chiral catalyst to produce a stereoisomerically enriched product, wherein said dienophile is represented by formula 119, said 1,3-diene is represented by formula 118, and said chiral catalyst consists of an asymmetric tetradentate ligand, a metal atom, wherein said metal atom is not titanium, and a counterion, said catalyst having a rectangular planar or rectangular pyrimidal geometry. ##STR48## in which each occurrence of Z independently represents C(R.sub.50), Si(R.sub.50), N, or P, wherein R.sub.50 represents a hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, thiol, amine, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, silyl, ether, thioether, sulfonyl, selenoether, ketone, aldehyde, ester, or --(CH.sub.2).sub.m --R.sub.7 ;Y represents O, S, or N(R.sub.50); andR.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent independently for each occurrence hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, silyloxy, amino, nitro, thiol, amine, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, silyl, ether, thioether, sulfonyl, selenoether, ketone, aldehyde, ester, or --(CH.sub.2).sub.m --R.sub.7 ;R.sub.7 represents an aryl, a cycloalkyl, a cycloalkenyl, a heterocycle or a polycycle; andm is zero or an integer in the range of 1 to 8.