Patent ID: 7998472
Filing Date: 2011-08-16
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for treating a subject afflicted with a tumor comprising introducing into the subject's bloodstream a therapeutically effective number of genetically modified CD34 − stem cells, wherein (a) each of the genetically modified CD34 − stem cells contains an exogenous nucleic acid comprising (i) a cytotoxic protein-encoding region operably linked to (ii) a promoter or promoter/enhancer combination, whereby the cytotoxic protein is selectively expressed when the genetically modified CD34 − stem cells come into proximity with, and differentiate into endothelial-like cells in proximity with, tumor tissue undergoing angiogenesis, directly and/or indirectly causing tumor tissue death, and (b) the introduction of the genetically modified CD34 − stem cells is not preceded, accompanied or followed by myeloablation.