Patent ID: 8933202
Filing Date: 2015-01-13
Classification: A61K,A61P,C07K

Abstract:
1. A monoclonal antibody that binds to the extracellular domain of AXL and at least partially inhibits AXL activity, wherein the antibody comprises a heavy chain comprising (a) a CDRH1 as shown in SEQ ID NO: 22, (b) a CDRH2 as shown in SEQ ID NO: 23, and (c) a CDRH3 as shown in SEQ ID NO: 24, and a light chain comprising (d) a CDRL1 as shown in SEQ ID NO: 19, (e) a CDRL2 as shown in SEQ ID NO: 20, and (f) a CDRL3 as shown in SEQ ID NO: 21, or an monoclonal antibody recognizing the same epitope on the extracellular domain of AXL.