Patent ID: 7375217
Filing Date: 2008-05-20
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A method of preparing a compound of formula 1, comprising: combining a compound of formula 7 with a reducing agent in a reaction solvent to give a compound of formula 8; and combining said compound of formula 8 with a pharmaceutically acceptable acid to give said compound of formula 1; wherein independently for each occurrence: W is oxygen or sulfur; Q is oxygen, NR, N(acyl) or a bond; X R for each occurrence is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, and heteroaralkyl; R R R wherein R R R R R R R R p is 1, 2, 3, 4, 5, or 6; R R R R R provided that when R the absolute stereochemistry at a stereogenic center of formula 1 may be R or S or a mixture thereof and the stereochemistry of a double bond may be E or Z or a mixture thereof.