Patent ID: 8142794
Filing Date: 2012-03-27
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of treating a HCV infection or inducing an immune response in a patient comprising the step of administering to said patient an effective amount of an expression vector comprising a nucleotide sequence encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide substantially similar to SEQ ID NO: 1, provided that said polypeptide has sufficient protease activity to process itself to produce an NS5B protein and said NS5B protein is enzymatically inactive, wherein said polypeptide consists of SEQ ID NO: 1 or a sequence substantially similar to SEQ ID NO: 1, wherein said sequence substantially similar to SEQ ID NO: 1 differs from SEQ ID NO: 1 by 1-20 amino acids and maintains all or most T-cell antigen regions present in SEQ ID NO: 1, wherein said expression vector expresses said polypeptide from said nucleotide sequence in said patient.