Patent ID: 6242484
Filing Date: 2001-06-05
Classification: A61K,A61P,Y02A

Abstract:
A method for treating a subject having a disease caused by infection with a protozoan parasite, the method comprising administering to the subject an effective amount of a compound having the formula: ##STR3##and pharmaceutically acceptable salts thereof, wherein R is selected from the group consisting ofa) H,b) P(O)(OH).sub.2,c) P(O)(OH)(OM), wherein M is selected from the group consisting of an alkali metal salt and an alkaline earth metal salt,d) P(O)OM.sub.2 wherein M is each independently selected from the group consisting of alkali metal salts and alkaline earth metal salts,e) Alkyl of 1 to 12 carbon atoms having 0 to 6 double bonds,f) (CH.sub.2).sub.n morpholine, wherein n=1-4,g) morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl,h) (CH.sub.2).sub.n COOR.sub.2, wherein n=1-4, R.sub.2 is selected from the group consisting of H, an alkalai metal salt, an alkaline earth metal salt, NH.sub.4.sup.+, and N.sup.+ (R.sub.3).sub.4, wherein R.sub.3 is each independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms, andi) COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3 wherein n=0-6, (CH.sub.2).sub.n COOR.sub.2, wherein n=1-4 and R.sub.2 is as previously defined, and (CH.sub.2).sub.n N.sup.+ (R.sub.3).sub.4, wherein n=1-4 and R.sub.3 is as previously defined.