Patent ID: 6172224
Filing Date: 2001-01-09
Classification: C07D

Abstract:
A process for separating 2-amino-6-chloro-9-[(1'S,2'R)-1',2'-bis(hydroxymethyl)-cyclopropane-1'-yl] methylpurine, represented by formula (5) ##STR7##from a mixture of 2-amino-6-chloro-7-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine, represented by formula (6) ##STR8##and 2-amino-6-chloro-9-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine, which process comprises crystallizing 2-amino-6-chloro-9-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine from a solvent containing 2-amino-6-chloro-7-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine and 2-amino-6-chloro-9-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine; and separating 2-amino-6-chloro-9-[(1'S,2'R)-1 ',2'-bis(hydroxymethyl)cyclopropane-1'-yl]methylpurine from 2-amino-6-chloro-7-[(1'S,2'R)-1',2'-bis(hydroxymethyl)cyclopropane-1'-yl]m ethylpurine.