Patent ID: 6313163
Filing Date: 2001-11-06
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for treating a disease or condition responsive to treatment by retinoids, comprising administering to a mammal in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a compound having the Formula 1 ##STR10##wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR11##Y is cyclopropyl optionally substituted with one or two R.sub.4 groups, the divalent Y radical being substituted by the Z and -(CR.sub.1.dbd.CR.sub.1 --CR.sub.1.dbd.CR.sub.1)-- groups on adjacent carbons;X is S,O or NR.sub.5 ;n is 1 or 2;R.sub.1 and R.sub.2 independently are H, lower alkyl or fluoroalkyl;R.sub.3 is hydrogen, lower alkyl, Cl or Br;R.sub.4 is lower alkyl, fluoroalkyl or halogen;R.sub.5 is H or lower alkyl, andB is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, -CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, -COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 OR.sub.13 O, or tri-lower alkylsilyl, where R.sub.7 is an alkyl group containing 1 to 5 carbons, a cycloalkyl group containing 3 to 5 carbons, or alkenyl group containing 2 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, a cycloalkyl group of 5 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons.