Patent ID: 6504034
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound of formula: or the pharmaceutically acceptable salts or esters thereof, wherein:R1 is selected from the group consisting of â€”H, â€”OR5, halogen, â€”CN, â€”NO2, â€”COR5, â€”COOR5, â€”CONR5R6, â€”NR5R6, â€”S(O)nR5, â€”S(O)2NR5R6, and lower alkyl which optionally may be substituted by R7; R2 is selected from the group consisting of â€”H, â€”OR5, â€”halogen, â€”CN, â€”NO2, â€”COR5, â€”COOR5, â€”CONR5R6, â€”NR5R6, â€”S(O)nR5, â€”S(O)2NR5R6, lower alkyl which optionally may be substituted by R7, cycloalkyl which optionally may be substituted by R87 and heterocycle which optionally may be substituted by R8; R3 and R4 are each independently selected from the group of â€”H, â€”OR5, â€”CN, â€”NO2, â€”COR5, â€”COOR5, â€”CONR5R6, â€”NR5R6, â€”S(O)nR5, â€”S(O)2NR5R6, and lower alkyl which optionally may be substituted by R7; R5 is selected from the group consisting of â€”H lower alkyl which optionally may be substituted by R7, cycloalkyl which optionally may be substituted by R8, aryl which optionally may be substituted by R8, heteroaryl which optionally may be substituted by R8, and heterocycle which optionally may be substituted by R8; R6 is selected from the group of â€”H â€”COR9, â€”CONR9R10, â€”S(O)nR9, â€”S(O)2NR9R10, lower alkyl which optionally may be substituted by R7, and cycloalkyl which optionally may be substituted by R8, or, alternatively, NR5R6 optionally may form a ring having 5-6 atoms, and said ring not being a morpholine, piperazine or piperidine said ring optionally having one or more additional hetero atoms and being optionally substituted by R8;R7 is selected from the group of â€”OR9, halogen â€”CN, â€”NO2, â€”COR9, â€”COOR9, â€”CONR9R10, â€”NR9R10, â€”S(O)nR9, â€”S(O)nNR9R10; R8 is selected from the group of â€”OR9, â€”CN, &boxH;O, â€”NO2, â€”COR9, â€”COOR9, â€”CONR9R10, â€”NR9R10, â€”S(O)nR9, â€”S(O)2NR9R10, and lower alkyl which optionally may be substituted by R7; R9 is selected from the group of â€”H, lower alkyl, and cycloalkyl; R10 is selected from the group consisting of â€”H, â€”COR11, lower alkyl, and cycloalkyl, or, alternatively, NR9R10 optionally may form a ring having 5-6 atoms, and said ring not being a morpholine, piperazine or piperidine said ring optionally having one or more additional hetero atoms;R11 is selected from the group consisting of lower alkyl, and cycloalkyl; a is an optional bond; and n is 0, 1 or 2.