Patent ID: 8822465
Filing Date: 2014-09-02
Classification: A61P,C07D

Abstract:
1. A compound of general formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein, X is O, S, NH, NCH3; Y is H, halogen; n is an integral between 2 and 6; R1 and R2 are identical or different, and independently and respectively selected from the group consisting of hydrogen, C1-C10alkyl, C3-C7cycloalkyl, C2-C10alkenyl and C2-C10alkynyl, which can be optionally substituted by 1-3 identical or different R4 substituents; or R1 and R2 together with the nitrogen atom bonded thereto form 5-10 membered heterocyclyl or 5-10 membered heteroaryl, said heterocyclyl and heteroaryl optionally contain 1-4 hetero atoms selected from N, O and S besides the nitrogen atom bonded to R1 and R2, said heterocyclyl optionally comprises 1 or 2 carbon-carbon double bonds besides the nitrogen atom bonded to R1 and R2, said heterocyclyl and heteroaryl are optionally substituted by 1-3 identical or different R4 substituents; R4 is C1-C6alkyl, hydroxy, cyano, carboxyl, an ester group; R3 is H, C1-C4alkyl, C3-C6cycloalkyl, allyl, —CH2-Ar1; Ar1 is phenyl, and optionally substituted by 1-3 identical or different R5 substituents; Ar is C6-C10aryl, 5-10 membered heteroaryl, wherein said heteroaryl contains 1-3 hetero atoms selected from N, O and S, and Ar is optionally substituted by 1-3 identical or different R5 substituents; R5 is hydroxy, halogen, nitro, amino, cyano, (C1-C6)alkyl, (C1-C6)alkenyl, (C1-C6)alkynyl, (C1-C6)alkoxyl, (C1-C6)alkyl or (C1-C6)alkoxyl optionally substituted by hydroxy, amino or halogen, mono or di[(C1-C6)alkyl] substituted amino, (C1-C6)alkylamido, a carboxyl radical which is free, salified, esterified or amidated, (C1-C6)alkylsulfinyl, sulfonyl, (C1-C6)alkoxyl, (C1-C6)alkyl, (C1-C6)alkylacyl, carbamoyl, mono or di(C1-C6alkyl) substituted carbamoyl, (C1-C3)alkylenedioxy.