Patent ID: 7300774
Filing Date: 2007-11-27
Classification: A61K,C07K

Abstract:
1. A soluble multimeric polypeptide of at least two trimer units, wherein each trimer unit comprises a fusion protein trimer strand consisting of: a first polypeptide comprising the first about 100 to 250 N-terminus residues of a collectin family scaffold protein, wherein the first polypeptide comprises a hub and a body region of the collectin family scaffold protein; and a second polypeptide comprising the last about 100 to 250 C-terminus residues of a tumor necrosis factor superfamily (TNFSF) ligand, wherein the second polypeptide comprises an extracellular domain (ECD) of the TNFSF ligand, wherein the carboxy-terminal residue of the first polypeptide is operably linked to the amino-terminal residue of the second polypeptide via: whereby a single trimer strand spontaneously trimerizes with two additional trimer strands to form a trimer unit and the trimer unit binds at the hub to form the multimeric polypeptide.