Patent ID: 6448266
Filing Date: 2002-09-10
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (I), its acid addition salt, carboxyl group salt, or hydrate thereof: R1 and R2, each independently represent a hydrogen atom, a hydroxyl group, a halogen atom, a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxyl group having 1 to 6 carbon atoms or an alkylthio group having 1 to 6 carbon atoms with the proviso that R1 and R2 are not both hydrogen atoms, wherein the alkyl group may have one or more substituents selected from the group consisting of a hydroxyl group, a halogen atom and an alkoxyl group having 1 to 6 carbon atoms, R3 and R4, each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, wherein the alkyl group may have one or more substituent selected from the group consisting of a hydroxyl group, a halogen atom, an alkylthio group having 1 to 6 carbon atoms and an alkoxyl group having 1 to 6 carbon atoms, n is an integer of 2, Q is a partial structure represented by the following formula: wherein R5 represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a halogenoalkyl group having 1 to 6 carbon atoms, a cyclic alkyl group having 3 to 6 carbon atoms which may have a substituent, a phenyl group which may have 1-3 substituents selected from the group consisting of fluorine, chlorine, bromine, hydroxyl group, amino group, nitro group, alkyl group having 1 to 6 carbon atoms and an alkoxyl group having 1 to 6 carbon atoms, a 5-6 membered heterocyclic group which contains 1 or more hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur and which may have a substituent selected from an alkyl group having 1 to 6 carbon atoms and a halogen atom, an alkoxyl group having 1 to 6 carbon atoms or an alkylamino group having 1 to 6 carbon atoms, R6 represents a hydrogen atom or an alkylthio group having 1 to 6 carbon atoms, wherein R6 and the aforementioned R5 may together form a 4-6 membered cyclic ring structure including A2 and the adjacent carbon to which R6 is linked, and the thus formed ring may contain a sulfur atom as a ring constituting atom, and the ring may also have an alkyl group having 1 to 6 carbon atoms as a substituent, R7 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms or an alkoxyl group having 1 to 6 carbon atoms, wherein said amino group may have one or more substituent(s) selected from the group consisting of a formyl group, an alkyl group having 1 to 6 carbon atoms and an acyl group having 2 to 5 carbon atoms, X1 represents a halogen atom or a hydrogen atom, A1 represents a partial structure represented by the following formula (II): X2 represents a hydrogen atom, an amino group, a halogen atom, a cyano group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms or an alkoxyl group having 1 to 6 carbon atoms, wherein the amino group may have one or more substituent selected from the group consisting of a fomyl group, an alkyl group having 1 to 6 carbon atoms and an acyl group having 2 to 5 carbon atoms, and X2 and the aforementioned R5 may together form a 4-7 membered cyclic ring structure including the carbon atom to which X2 is linked and A2 to which R5 is linked, and the thus formed ring may contain an oxygen atom, a nitrogen atom or a sulfur atom as a ring constituting, and the ring may also have an alkyl group having 1 to 6 carbon atoms as a substituent, A2 represents a nitrogen atom, A3 represents a carbon atom, wherein A2 and A3 together with carbon atoms to which they are linked form a partial structure: Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms or a phenylalkyl group composed of an alkylene group having 1 to 6 carbon atoms and a phenyl group.