Patent ID: 8765780
Filing Date: 2014-07-01
Classification: A61P,C07D

Abstract:
1. A compound of formula I.1 wherein the bicyclic azacycloalkene core structure of formula I.1 condensed with ring A and attached to the carbonyl group is optionally substituted with 1 to 5 substituents, independently of each other selected from the group consisting of R A denotes a benzo ring, which is optionally substituted with one to four substituents independently of each other selected from R B denotes a 6-membered monocylic, cycloalkyl group which is optionally saturated or partially unsaturated, and R R R R R R R L L or L L L while by aryl is meant phenyl or naphthtyl and by heteroaryl is meant pyrrolyl, furanyl, thienyl, pyridyl, indolyl, benzofuranyl, benzothio-phenyl, quinolinyl, isoquinolinyl, or pyrrolyl, furanyl, thienyl, and pyridyl wherein in each 1 or 2 CH groups are replaced by N, or indolyl, benzofuranyl, benzothiophenyl, quinolinyl, and isoquinolinyl wherein in each 1 to 3 CH groups are replaced by N, and wherein each >N—H containing heteroaryl all the >N—H groups present are optionally replaced by other groups independently selected from >N—R while the (het)aryl mentioned hereinbefore as a single unit or a sub-moiety within another group is an aryl group as defined hereinbefore, or a heteroaryl group as defined hereinbefore, or a ring selected from the group consisting of 1,2-dihydro-2-oxo-pyridinyl, 1,4-dihydro-4-oxo-pyridinyl, 2,3-dihydro-3-oxo-pyridazinyl, 1,2,3,6-tetrahydro-3,6-dioxo-pyridazinyl, 1,2-dihydro-2-oxo-pyrimidinyl, 3,4-dihydro-4-oxo-pyrimidinyl, 1,2,3,4-tetrahydro-2,4-dioxo-pyrimidinyl, 1,2-dihydro-2-oxo-pyrazinyl, 1,2,3,4-tetrahydro-2,3-dioxo-pyrazinyl, 2,3-di-hydro-2-oxo-indolyl, 2,3-dihydrobenzofuranyl, 2,3-dihydro-2-oxo-1H-benzimidazolyl, 2,3-dihydro-2-oxo-benzoxazolyl, 1,2-dihydro-2-oxo-quinolinyl, 1,4-dihydro-4-oxo-quinolinyl, 1,2-dihydro-1-oxo-isoquinolinyl, 1,4-dihydro-4-oxo-cinnolinyl, 1,2-dihydro-2-oxo-quinazolinyl, 1,4-dihydro-4-oxo-quinazolinyl, 1,2,3,4-tetrahydro-2,4-dioxo-quinazolinyl, 1,2-dihydro-2-oxoquinoxalinyl, 1,2,3,4-tetrahydro-3-oxo-quinoxalinyl, 1,2,3,4-tetrahydro-2,3-dioxo-quinoxalinyl, 1,2-dihydro-1-oxo-phthalazinyl, 1,2,3,4-tetrahydro-1,4-dioxo-phthalazinyl, chromanyl, coumarinyl, 2,3-dihydro-benzo[1,4]dioxinyl and 3,4-dihydro-3-oxo-2H-benzo-[1,4]oxazinyl, wherein each of said rings is optionally substituted with 1, 2 or 3 substituents independently of each other selected from R wherein each >N—H containing (het)aryl all the >N—H groups present are optionally replaced by other groups independently selected from >N—R whilst each of the above-mentioned alkyl or alkylene moieties may be branched or unbranched, a tautomer, stereoisomer thereof, mixture thereof, or salt thereof.