Patent ID: 8394396
Filing Date: 2013-03-12
Classification: A61K,C01B,C01F,C01G,C01P

Abstract:
1. A method of making an inorganic porous particle comprising an inorganic compound that provides an inorganic solid phase including an external particle surface, and further comprising a first set of pores wherein the pores have an average diameter of less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm, which second set of pores comprise stabilizing organic microgel particles, and the first and second sets of pores are isolated from each other in the inorganic solid phase, the method comprising: providing a first oil phase comprising a first water-immiscible aprotic solvent having a dielectric constant of less than 10 and having dissolved therein organic microgel particles, providing an aqueous phase comprising a polar solvent, an inorganic gel precursor, a catalyst, and a dispersing surfactant, neutralizing the aqueous phase to initiate condensation of the inorganic gel precursor, providing an oil-in-water emulsion that comprises the organic microgel particles in the first oil phase, which is dispersed as first oil phase droplets in the aqueous phase, providing a second oil phase comprising a second water-immiscible aprotic solvent having a dielectric constant of less than 10 and a dispersing surfactant, combining the oil-in-water emulsion with the second oil phase to form an oil-in-water-in-oil emulsion comprising the first oil phase droplets in the aqueous phase, which is dispersed as aqueous phase droplets in the second oil phase, condensing the inorganic gel precursor in the aqueous phase droplets, and forming precursor inorganic porous particles wherein the inorganic porous particles contain a first set of pores wherein the pores have an average diameter less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm.