Patent ID: 8273902
Filing Date: 2012-09-25
Classification: A61P,C07D

Abstract:
1. A process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol, a salt of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol, or a combination thereof, the process comprising: (A) reducing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propionyl)azetidin-3-ol with an activator in the presence of an alkali metal borohydride, wherein the activator is at least one compound selected from the group consisting of a protonic acid, a methylating agent, and a silylating agent.