Patent ID: 7037890
Filing Date: 2006-05-02
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A pharmaceutical composition comprising a compound of Formula I, wherein A is a MetAP-2 inhibitory core; W is O or NR; each R is, independently, hydrogen or alkyl; Z is —C(O)— or -alkylene-C(O)—; P is NHR, OR or a peptide consisting of one to about one hundred amino acid residues connected at the N-terminus to Z; Q is hydrogen, linear, branched or cyclic alkyl or aryl, provided that when P is —OR, Q is not hydrogen; or Z is -alkylene-O— or -alkylene-N(R)—; P is hydrogen or a peptide consisting of from one to about one hundred amino acid residues connected to Z at the carboxyl terminus; Q is hydrogen, linear, branched or cyclic alkyl or aryl, provided that when P is hydrogen, Q is not hydrogen; or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.