Patent ID: 6482978
Filing Date: 2002-11-19
Classification: C07C

Abstract:
A method for producing an aromatic acylthiocarboxylic acid derivative of the formula (3) wherein A is an optionally substituted aryl having 6 to 15 carbon atoms, an optionally substituted aralkyl having 7 to 20 carbon atoms or a group having a carbon skeleton of said aryl or aralkyl and comprising a heteroatom in the skeleton, and R is an alkyl having 1 to 6 carbon atoms, an aryl having 6 to 10 carbon atoms or an aralkyl having 7 to 11 carbon atoms, which method comprises the steps of(a) reacting an aromatic amino acid of the following formula (1) wherein A is as defined above, in an aqueous solvent in the presence of sodium nitrite, hydrogen bromide and at least one member selected from the group consisting of an aliphatic carboxylic acid and an alcohol, to produce an aromatic bromocarboxylic acid derivative of the formula (2) wherein a is as defined above, and(b) reacting the aromatic bromocarboxylic acid derivative and an organic thio acid in the presence of an amine.