Patent ID: 8741304
Filing Date: 2014-06-03
Classification: A61K,A61P,C07K

Abstract:
1. A method for eliciting an immune response to NTHi bacteria comprising administering an immunogenic dose of a chimeric protein to a patient at risk of NTHi bacterial infection wherein the chimeric protein comprises i) an immunogenic PilA peptide selected from the group consisting of the amino acid sequence of SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or residues 40 to 149 of SEQ ID NO: 2 and ii) the LB 1 peptide selected from the group consisting of the amino acid sequence of SEQ ID NO: 4 and SEQ ID NO: 5, wherein the LB 1 peptide is inserted before the immunogenic PilA peptide.