Patent ID: 6326402
Filing Date: 2001-12-04
Classification: A61K,A61P

Abstract:
A method of treating a viral infection in a mammal needing such treatment comprising the step of administering a pharmaceutically effective amount of a compound having no significant hormonal activity capable of binding microtubules or inhibiting microtubule formation or inhibiting tubulin polymerization wherein said compound has the formula: ##STR9##and pharmaceutically acceptable salts thereof, wherein:X=O, S, CH.sub.2, carboxy or absent;Y=O or S;R.sub.1 =methyl or ethyl;R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of: H, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkenyl, (C.sub.1 -C.sub.4) alkynyl, hydroxyl, (C.sub.1 -C.sub.4) alkoxy and halogen: andR.sub.6, R.sub.7, R.sub.8, and R.sub.9 are independently selected from the group consisting of: H, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkenyl, (C.sub.1 -C.sub.4) alkynyl, hydroxyl, (C.sub.1 -C.sub.4) alkoxy, halogen, NO.sub.2 and NH.sub.2.