Patent ID: 8383825
Filing Date: 2013-02-26
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method of treating an ocular condition of an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising a tyrosine kinase inhibitor and a biodegradable polymer matrix, wherein the implant degrades at a rate effective to sustain release of an amount of the tyrosine kinase inhibitor from the implant effective to treat the ocular condition, wherein said ocular condition is diabetic retinopathy, and wherein the tyrosine kinase inhibitor is a compound of formula I or a prodrug, pharmaceutically acceptable salt, racemic mixture or enantiomer of said compound, wherein: X is CR Y is CR R′ is selected from the group consisting of hydrogen, alkyl, halogen, OR R R R A is selected from the group consisting of C≡C, CH═CH, CH B is selected from the group consisting of hydrogen, alkyl and alkyloxyalkyl or B may be a 5 or 6 membered carbocyclic aryl or heterocyclic aryl group; E is a 5 or 6 membered carbocyclic aryl or heterocyclic aryl group; E′ is selected from the group consisting of alkyl, CF R R R a is 0 or an integer of from 1 to 5; b is an integer of from 2 to 5; c is 0 or an integer of from 1 to 4; d is 0 or an integer of from 1 to 5; and e is 0 or an integer of from 1 to 2.