Patent ID: 8741346
Filing Date: 2014-06-03
Classification: A61K,A61P,B82Y

Abstract:
1. A method for the preparation of soluble molecular complexes, said method consisting essentially of: (a) mixing one or more active substances which are poorly soluble in an aqueous medium with one or more host molecule components selected from the group consisting of β-cyclodextrin, methyl-β-cyclodextrin, γ-cyclodextrin, and hydroxypropyl-β-cyclodextrin, and separately adding water as a diffusion agent in an amount of between 8.4% and 50% by mass of the entire mixture in the absence of an organic solvent; (b) carrying out a molecular diffusion step by bringing supercritical carbon dioxide under pressure into contact, in static mode, with the mixture obtained in step (a), wherein the pressure is between 5 MPa and 40 MPa and the temperature is between 0 and 120° C., thereby forming a molecular complex; and (c) recovering the molecular complex.