Patent ID: 6133243
Filing Date: 2000-10-17
Classification: A61K,A61P

Abstract:
A method for treating cancer in a mammal in need of said treatment, said cancer comprising a cell population of non-neoplastic and neoplastic cells, comprising the steps of;administering to said animal at the site of said tumor an effective amount of a complex consisting of liposomal viral DNA, said viral DNA being substantially purified adenoviral DNA not in an expression vector and that lacks an expressed viral oncoprotein capable of binding to a functional p53 tumor suppressor protein, and said viral DNA having the further properties of replicating and forming infectious virus in said neoplastic cells that lack functional p53 thereby killing said neoplastic cells and substantially incapable of replicating and forming infectious virus in non-neoplastic cells that have said p53 tumor suppressor protein.