Patent ID: 9089677
Filing Date: 2015-07-28
Classification: A61K,A61M,Y10T

Abstract:
1. A transcutaneous multimodal delivery device (TMDS), comprising a transcutaneous drug delivery (TDD) component and a sustained delivery and retention (SDR) component; wherein the TMDS provides a controlled delivery of at least one active agent comprising a first therapeutic drug or a second therapeutic drug where the first therapeutic drug and the second therapeutic drug are the same or different; wherein the TDD component comprises dissolvable microneedles at least one of which having a sharp tip and a blunt tip, wherein the sharp tip has a dimension so as to allow the microneedles to penetrate eschar of skin without reaching viable tissue, and wherein the blunt tip is enclosed within the sharp tip and has a tip angle that is less sharp than that of the sharp tip, wherein the SDR component comprises a plurality of release control vehicles comprising the first therapeutic drug or second therapeutic drug to provide controlled release of the first therapeutic drug or the second therapeutic drug, and wherein the plurality of release control vehicles of the SDR component is enclosed within the blunt tip and the sharp tip of the dissolvable microneedles of the TDD component and released upon dissolution of the dissolvable microneedles.