Patent ID: 8758827
Filing Date: 2014-06-24
Classification: A61J,A61K,A61L,A61P

Abstract:
1. Process for the production of a local system for the release of an active principle which consists of spherical or rotationally symmetrical bodies which are composed essentially of i) polymethyl methacrylate and polymethyl methacrylate co-methyl acrylate, ii) zirconium dioxide and/or barium sulphate, and iii) one or more pharmaceutically active principles, said local system not containing radical polymerization activators which are effective in the temperature range of 10-80° C. selected from the group consisting of aromatic amines, heavy metal salts and barbiturates, or residues thereof, by local polymerization, which comprises a) producing a paste by mixing methyl methacrylate, optionally polymethyl methacrylate, polymethyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, one or more pharmaceutical active principles, and a thermally decomposing radical initiator, the paste having a viscosity sufficient to prevent deformation at room temperature by the effect of gravity; b) injection moulding the paste by an injection moulding device into spherical or rotationally symmetrical bodies or injection moulding spherical or rotationally-symmetrical bodies onto a wire; c) heating the bodies to a temperature at which the thermally decomposing radical initiator decomposes and polymerizing the methyl methacrylate.