Patent ID: 8937084
Filing Date: 2015-01-20
Classification: A61P,C07D,G01N

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: R R (a) hydrogen or carboxamido; or (b) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, (cycloalkyl)alkyl, (cycloalkenyl)alkyl, (heterocyclo)alkyl, arylalkyl, heteroarylalkyl, alkylcarbonyl, alkoxycarbonyl, (arylalkoxy)carbonyl, or (heteroarylalkoxy)carbonyl, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, alkyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclo, cycloalkyl, and cycloalkenyl, wherein said aryl, heteroaryl, heterocyclo, cycloalkyl, and cycloalkenyl are optionally substituted with 1, 2, or 3 independently selected R R R R Z is selected from the group consisting of a) hydrogen, b) (cycloalkyl)alkyl, c) (cycloalkenyl)alkyl, d) arylalkyl, e) heteroarylalkyl, f) (heterocyclo)alkyl, g) -alkyl-C(═O)NR h) -alkyl-C(═O)OR i) —C(═O)-alkyl-NR j) —C(═O)-alkyl-OR k) cyanoalkyl, wherein the cycloalkyl, aryl, heteroaryl and heterocyclo portions are optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of alkyl, hydroxy, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, and aminocarbonyl; and wherein R each R Y is C═O or CH