Patent ID: 6465468
Filing Date: 2002-10-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I) whereinn 1; m=1; X is S(O)1-2; Y is NHOH; R1 is H, OR7 or a group (optionally substituted with R3) selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl; and R2 is H or C1-6 alkyl; or CR1R2 is cycloalkyl or heterocycloalkyl optionally substituted with R3 or a group (optionally substituted with R3) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl; R3 is OR7, COR7, CO2R8, CON(R7)2, N(R7)2, NR7COR7, NR7CON(R7)2, NR7CO2R8, NR7SO2R8, S(O)0-2R8, SO2N(R7)2 or cycloimidyl (optionally substituted with R4); R4 is C1-6 alkyl; B is H or a group (optionally substituted with R5 or R6) selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl, C1-6 alkyl-heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl; and each instance of B may be the same or different; or Bâ€”Nâ€”B is heterocycloalkyl optionally substituted with R5, R6, &boxH;O or &boxH;NOR5; R5 is a group (optionally substituted with R6) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl; R6 is a group selected from N(R7)2, NR7COR7, NR7CON(R7)2, NR7CO2R8, NR7SO2R8, OR7, COR7, CO2R4, CON(R7)2, S(O)0-2R8 or SO2N(R7)2; R7 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R8, COR8, SO0-2R8, CO2R8, OR8, CONR4R8, NR4R8 or SO2NR4R8 and for each case of N(R7)2 the R7 groups are the same or different or N(7)2 is heterocycloalkyl optionally substituted with R8, COR8, S(O)0-2R8, CO2R8, OR8, CONR4R8, NR4R8 or SO2NR4R8; and R8 is C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl; or a salt, solvate, hydrate, N-oxide, protected amino, protected carboxy or protected hydroxamic acid derivative thereof.