Patent ID: 9051607
Filing Date: 2015-06-09
Classification: A61P,C12N,C12Q

Abstract:
1. A method for detecting chromosomal abnormalities in a plurality of cells in a cervical sample, said method comprising: a) hybridizing a first nucleic acid sequence to a target nucleic acid sequence on chromosome 3q; b) hybridizing a second nucleic acid sequence to a target nucleic acid sequence on chromosome 5p; c) detecting the hybridization signal of the first and second nucleic acid sequences, wherein the hybridization signal is indicative of chromosomal copy number for 3q and 5p d) scoring the chromosomal copy number for chromosome 3q and 5p; and e) reporting whether the sample contains chromosomal abnormalities, wherein the sample is judged to be negative or have normal ploidy if a ratio of the chromosomal copy number for chromosome 3q to the total number of nuclei is less than 2 and the chromosomal copy number for chromosome 5p to the total number of nuclei is less than 2.