Patent ID: 9120875
Filing Date: 2015-09-01
Classification: A61K,A61P,C07K

Abstract:
1. A method of increasing one or both of affinity for FcRn and serum half-life of a protein or non-protein agent comprising conjugating the protein or non-protein agent to a polypeptide comprising a human serum albumin (HSA) portion, which HSA portion comprises HSA domain III, or a neonatal Fc receptor (FcRn) binding fragment thereof, wherein: the HSA portion comprises one or more amino acid substitutions at positions chosen from positions 463, 508, 523 and 524, which positions are numbered relative to positions in full length mature HSA (SEQ ID NO: 2); the one or more amino acid substitutions increase one or both of affinity for FcRn and serum half-life of the polypeptide relative to a control polypeptide in which the HSA portion does not include the one or more amino acid substitutions; and an amino acid substitution at position 508, if present in the HSA portion, is chosen from lysine, arginine and serine.