Patent ID: 8815853
Filing Date: 2014-08-26
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (Ia): wherein: R1a represents a linear or branched alkyl, alkenyl or alkynyl radical, a cycloalkyl radical or a heterocycloalkyl radical, containing from 1 to 7 carbon atoms, all these radicals being optionally substituted with one or several radicals, either identical or different, selected from halogen atoms and the radicals R7a, —S(O)xa-R7a with xa representing the integer 0, 1 or 2, —SO R2a represents a hydrogen atom, an alkyl radical or a cycloalkyl; R3a represents an alkyl radical, a cycloalkyl or phenyl radical optionally substituted with one or several radicals either identical or different selected from halogen atoms and radicals —OR5a and —NR5aR6a; R2a and R3a may optionally form with the carbon atom to which they are bound a cyclic radical containing 3 to 10 members and optionally one or several other heteroatoms selected from O, S and —NR5a, this cyclic radical being optionally substituted with one or several radicals either identical or different, selected from halogen atoms, oxo, R5a, —OR5a and —NR5aR6a radicals; R4a represents a hydrogen atom, an alkyl radical, a halogen atom or a —CN radical; with R5a and R6a either identical or different representing a hydrogen atom or an alkyl, cycloalkyl or heterocycloalkyl radical and R7a, either identical or different from R5a and R6a, represents an alkyl, cycloalkyl or heterocycloalkyl radical, the alkyl, cycloalkyl, heterocycloalkyl radicals above, which R5a, R6a and R7a may represent, being themselves optionally substituted with one or several radicals, either identical or different, selected from halogen atoms, —OR8a and —NR8aR9a with R8a and R9a either identical or different representing a hydrogen atom or an alkyl, cycloalkyl or heterocycloalkyl radical; said products of formula (Ia) being in all the racemic, enantiomeric and diastereoisomeric possible isomeric forms, as well as addition salts with inorganic and organic acids or with inorganic and organic bases of said products of formula (Ia).