Patent ID: 8002987
Filing Date: 2011-08-23
Classification: B01J,C07D

Abstract:
1. A method of separating taxane, the method comprising: preparing a column for taxane separation, the column being packed with a stationary phase comprising a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 below is covalently bound to a modified silica gel represented by Formula 3 below; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract: wherein at least one of R X is O, S, or NH; and n is an integer of 4 to 20, wherein at least one of R's is selected from the group consisting of hydrogen, a hydroxy group, a substituted or unsubstituted alkyloxy group of C1-C30, a substituted or unsubstituted alkenyloxy group of C1-C30, a substituted or unsubstituted alkynyloxy group of C1-C30, a substituted or unsubstituted carbonylalkyloxy group of C2-C30, a substituted or unsubstituted thioalkyloxy group of C1-C30, a substituted or unsubstituted alkylthioloxy group of C1-C30, a substituted or unsubstituted hydroxyalkyloxy group of C1-C30, a substituted or unsubstituted alkylsiloxy group of C1-C30, a substituted or unsubstituted aminoalkyloxy group of C1-C30, a substituted or unsubstituted aminoalkylthiolalkyloxy group of C1-C30, a substituted or unsubstituted cycloalkyloxy group of C5-C30, a substituted or unsubstituted heterocycloalkyloxy group of C2-C30, a substituted or unsubstituted aryloxy group of C6-C30, a substituted or unsubstituted arylalkyloxy group of C6-C20, a substituted or unsubstituted heteroaryloxy group of C4-C30, a substituted or unsubstituted heteroarylalkyloxy group of C4-C30, a substituted or unsubstituted alkylthio group of C1-C30, a substituted or unsubstituted alkenylthio group of C1-C30, a substituted or unsubstituted alkynylthio group of C1-C30, a substituted or unsubstituted carbonylalkylthio group of C2-C30, a substituted or unsubstituted thioalkylthio group of C1-C30, a substituted or unsubstituted hydroxyalkylthio group of C1-C30, a substituted or unsubstituted alkylsilylthio group of C1-C30, a substituted or unsubstituted aminoalkylthio group of C1-C30, a substituted or unsubstituted aminoalkylthiolalkylthio group of C1-C30, a substituted or unsubstituted cycloalkylthio group of C5-C30, a substituted or unsubstituted heterocycloalkylthio group of C2-C30, a substituted or unsubstituted arylthio group of C6-C30, a substituted or unsubstituted arylalkylthio group of C6-C20, a substituted or unsubstituted heteroarylthio group of C4-C30, a substituted or unsubstituted heteroarylalkylthio group of C4-C30, a substituted or unsubstituted alkylamine group of C1-C30, a substituted or unsubstituted alkenylamine group of C1-C30, a substituted or unsubstituted alkynylamine group of C1-C30, a substituted or unsubstituted carbonylalkylamine group of C2-C30, a substituted or unsubstituted thioalkylamine group of C1-C30, a substituted or unsubstituted hydroxyalkylamine group of C1-C30, a substituted or unsubstituted alkylsilylamine group of C1-C30, a substituted or unsubstituted trialkyloxysilyl alkyl-carbamate group of C1-C30, a substituted or unsubstituted trialkyloxysilyl alkyl-thiocarbamate group of C1-C30, a substituted or unsubstituted trialkyloxysilyl alkyloxy group of C1-C30, a substituted or unsubstituted trialkyloxysilyl alkyl-carbonyloxy group of C1-C30, a substituted or unsubstituted trialkyloxysilyl heteroalkyl-alkyloxy group of C1-C30, a substituted or unsubstituted aminoalkylamine group of C1-C30, a substituted or unsubstituted aminoalkylthiolalkylamine group of C1-C30, a substituted or unsubstituted cycloalkylamine group of C5-C30, a substituted or unsubstituted heterocycloalkylamine group of C2-C30, a substituted or unsubstituted arylamine group of C6-C30, a substituted or unsubstituted arylalkylamine group of C6-C20, a substituted or unsubstituted heteroarylamine group of C4-C30, a substituted or unsubstituted heteroarylalkylamine group of C4-C30, a substituted or unsubstituted alkylazide group of C1-C30, a substituted or unsubstituted arylazide group of C1-C30, a substituted or unsubstituted alkylcarboxylazide group of C1-C30, and a substituted or unsubstituted arylcarboxylazide group of C1-C30; X is O, S, or NH; and n is an integer of 3 to 19, and wherein R