Patent ID: 7255876
Filing Date: 2007-08-14
Classification: A61K,A61P

Abstract:
1. A quick-disintegrating tablet composition, said quick-disintegrating tablet composition comprising (i) sustained-release fine particles further coated with an enteric polymer for quick-disintegrating tablets in the buccal cavity, characterized in that (ii) said tablet composition comprises the product by fluidized-bed granulation of sustained-release fine particles further coated with an enteric polymer containing tamsulosin hydrochloride coated on crystalline cellulose particles by a binder selected from the group consisting of hydroxypropyl cellulose, hydroxypropylmethyl cellulose and copolyvidone, and one or two or more fillers selected from the group consisting of sugars and sugar alcohols with a binder for quick-disintegrating tablets in the buccal cavity, and in that the ratio of ungranulated sustained-release fine particles in the entire composition is 0 to 15%; wherein the mixture ratio of sustained-release fine particles, further coated with an enteric polymer filler, and binder for quick-disintegrating tablets in the buccal cavity is 1 to 50%, 20 to 98%, and 1 to 30%, respectively, and wherein when said sustained-release fine particles further coated with an enteric polymer (i) and said quick-disintegrating tablets in the buccal cavity comprising the sustained-release fine particles further coated with an enteric polymer (ii) are compared by a dissolution time experiment for (i) and a dissolution time for (ii), 1) the difference between said dissolution time for (i) and said dissolution time for (ii) is 0 to 15% at each dissolution time when the drug dissolution of (i) is approximately 30%, approximately 50%, and approximately 80%; or 2) two hours after starting the dissolution experiment, the difference between said dissolution time of enteric (i) and said dissolution time of (ii) is 0 to 10%.