Patent ID: 9092391
Filing Date: 2015-07-28
Classification: G16B

Abstract:
1. A method of generating at least one Genetic Composite Index (GCI) score, wherein said GCI score represents an estimation of an individual's risk to a phenotype comprising: a) obtaining a genetic sample from said individual; b) generating a genomic profile from said genetic sample; c) determining at least two relative risks (RR) or odds ratios (OR) for a phenotype by comparing said individual's genomic profile to a current database of human genotype correlations wherein a human genotype correlation is a correlation between a genetic variant and a phenotype, wherein phenotype is selected from Alzheimers (AD), colorectal cancer (CRC), osteoarthritis (OA), exfoliation glaucoma (XFG), obesity (BMIOB), Graves Disease (GD), hemochromatosis (HEM), myocardial infarction (MI), multiple sclerosis (MS), psoriasis (PS), restless legs syndrome (RLS), celiac disease (CelD), prostate cancer (PC), lupus (SLE), macular degeneration (AMD), rheumatoid arthritis (RA), breast cancer (BC), Crohn's disease (CD), Type 2 diabetes (T2D), and a combination thereof, wherein the RR or OR are determined by and wherein the genomic variant is selected from SNP is:rs4420638 when said phenotype is AD; rs6983267 when said phenotype is CRC; rs4911178 when said phenotype is OA; rs2165241 when said phenotype is XFG; rs9939609 or rs9291171 when said phenotype is BMIOB; rs3087243, DRBI*0301 DQA1*0501 when said phenotype is GD; rs1800562 or rs129128 when said phenotype is HEM; rs1866389, rs1333049, or rs6922269 when said phenotype is MI; rs6897932, rs12722489, or DRB1*1501 when said phenotype is MS; rs6859018, rs11209026, or HLAC*0602 when said phenotype is PS; rs6904723, rs2300478, rs1026732, or rs9296249 when said phenotype is RLS; rs6840978, rs11571315, rs2187668, or DQA1*0301 DQB1*0302 when said phenotype is CelD; rs4242384, rs6983267, rs16901979, rs17765344, or rs4430796 when said phenotype is PC; rs12531711, rs10954213, rs2004640, DRB1*0301, or DRB1*1501 when said phenotype is SLE; rs10737680, rs10490924, rs541862, rs2230199, rs1061170, or rs9332739 when said phenotype is AMD; rs6679677, rs11203367, rs6457617, DRB*0101, DRB1*0401, or DRB1*0404 when said phenotype is RA; rs3803662, rs2981582, rs4700485, rs3817198, rs17468277, rs6721996, or rs3803662 when said phenotype is BC; rs2066845, rs5743293, rs10883365, rs17234657, rs10210302, rs9858542, rs11805303, rs1000113, rs17221417, rs2542151, or rs10761659 when said phenotype is CD; rs13266634, rs4506565, rs10012946, rs7756992, rs10811661, rs12288738, rs8050136, rs1111875, rs4402960, rs5215, or rs1801282 when said phenotype is T2D; d) calculating at least one GCI score from said at least two relative risks or odds ratios using e) reporting said at least one GCI score; and f) providing genetic counseling to the individual based on said at least one GCI score.