Patent ID: 6555536
Filing Date: 2003-04-29
Classification: A61P,C07D,C07F

Abstract:
A compound of Formula (I): or an optical isomer, enantiomer, diastereomer, racemate or racemic mixture thereof, ester, prodrug form, or a pharmaceutically acceptable salt thereof, whereinA is selected from aryl, heterocyclyl, and C1-C10 alkyl, said aryl, heterocyclyl, and C1-C10 alkyl being optionally substituted with one or more members selected from the group consisting of halogen, OH, aryl, C3-C8 cycloalkyl, C1-C10 alkyl substituted with a halogen, C1-C10 alkyl ether, heterocyclyl, carbonyl, oxime, â€”C(NNR3R4)R1, -COOR1, â€”CONR1R2, â€”OC(O)R1, â€”OC(O)OR1, â€”OC(O)NR1R2, â€”NR1R2, â€”NR3C(O)R1, â€”NR3C(O)OR1, and â€”NR3C(O)NR1R2, wherein R1 and R2 are independently selected from hydrogen, C1-C10 alkyl, aryl, heterocyclyl, and alkylaryl, or R1 and R2 may be taken together to form a 5- to 10-member ring; and R3 and R4 are independently selected from hydrogen, C1-C10 alkyl, aryl, heterocyclyl, alkylaryl, â€”C(O)R1, or â€”C(O)NR1R2; Z1 is selected from hydrogen, C1-C6 alkyl, aryl, heterocyclyl, COOR1, CONR1R2, OH, C1-C6 alkyl ether, â€”OC(O)R1, â€”OC(O)OR1, â€”OC(O)NR1R2, â€”NR1R2, â€”NR3C(O)R1, â€”NR C(O)OR1, â€”NR3C(O)NR1R2, halogen, â€”C(O)R1, â€”C(NR3)R1, â€”C(NOR3)R1, and â€”C(NNR3R4)R1; Z2 is selected from hydrogen, halogen, C1-C6 alkyl; Z1 and Z2 may together form a fused aromatic ring; n is an integer from 0 to 3; G is selected from â€”COOR1, â€”C(O)COOR1, â€”CONR1R2, â€”CF3, â€”P(O) (OR1) (OR2), â€”Sâ€”R8, R5 and R6 are independently hydrogen or C1-C6 alkyl; R7 is hydrogen, C1-C6 alkyl, or â€”C(O)R5; R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, and substituted C1-C6 alkyl; and B is oxygen or â€”NR5; E is selected from hydrogen, C1-C6 alkyl and a moiety of the formula X is hydrogen or oxygen, with the proviso that when E is hydrogen and G is â€”COOH, â€”COOCH3, or a moiety of the formula of A is selected from the group consisting of aryl, heterocyclyl, substituted C1-C6 alkyl, provided that when X is hydrogen, n is 1 and G is a moiety of the formula of A is selected from the group consisting of heterocyclyl.