Patent ID: 7097991
Filing Date: 2006-08-29
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A method of screening for an agent that modulates capsaicin receptor function, the method comprising: a) combining a candidate agent with a eukaryotic cell comprising a recombinant nucleic acid, wherein the recombinant nucleic acid comprises a nucleotide sequence that encodes a biologically active capsaicin receptor polypeptide, which nucleotide sequence is operably linked to a promoter, wherein said capsaicin receptor is encoded by a polynucleotide that hybridizes under stringent hybridization conditions to the complement of a polynucleotide having a nucleotide sequence selected from SEQ ID NO:10, SEQ ID NO:24, and SEQ ID NO:33, and wherein the capsaicin receptor polypeptide is expressed on the cell surface; and b) determining the effect of said agent on capsaicin receptor function.