Patent ID: 6784155
Filing Date: 2004-08-31
Classification: A61K,A61P,C07K

Abstract:
A method of stimulating stem cell proliferation comprising contacting hematopoietic cells with a stem cell proliferation stimulating amount of INPROL or an opiate compound or a stem cell proliteration stimulating amount of a combination of INPROL and an opiate compound,wherein said INPROL is selected from the group consisting of a polypeptide having the sequence of amino acids 1-97 of the human alpha hemoglobin chain, a polypeptide having the sequence of amino acids 1-94 of the human alpha hemoglobin chain, Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val (SEQ ID NO:1),Cys-Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Cys (SEQ ID NO:2)(where the two Cys residues form a disulfide bond), Asp-Ala-Leu-Thr-Asn-Ala-Val-Ala-His-Val-Asp-Asp-Met-Pro-Asn-Ala-Leu-Ser-Ala (SEQ ID NO:3),Phe-Leu-Gly-Phe-Pro-Thr (SEQ ID NO:33),Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe (SEQ ID NO:4),Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg (SEQ ID NO:5),Leu-Val-Val-Tyr-Pro-Trp-Thr (SEQ ID NO:6),Leu-Val-Val-Tyr-Pro-Trp-Thr (SEQ ID NO:7),Leu-Val-Val-Tyr-Pro-Trp (SEQ ID NO:8).Leu-Val-Val-Tyr-Pro (SEQ ID NO:9),Val-Val-Tyr-Pro-Trp-Thr-Gln (SEQ ID NO:10),Tyr-Pro-Trp-Thr-Gln-Arg-Phe (SEQ ID NO:11),Tyr-Pro-Trp-Thr-Gln-Arg (SEQ ID NO:12),Tyr-Pro-Trp-Thr-Gln (SEQ ID NO:13), andTyr-Pro-Trp-Thr (SEQ ID NO:27):wherein said stem cells are cells which can generate multiple lineages or other stem cells.