Patent ID: 6790836
Filing Date: 2004-09-14
Classification: A61K,A61P,C07H,Y02P

Abstract:
A process for preparation of an indolopyrrolocarbazole derivative represented by the formula [I]which comprises(1) treating a compound represented by the general formula [V]: wherein, Y1 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group, a benzyloxymethyl group or an aralkyl group, and R1, R2, R3, R4, R5 and R6 may be the same or different and each represent a protective group of a hydroxyl group, with a base in an inert solvent to obtain a compound represented by the general formula [IV]: wherein, R1, R2, R3, R4, R5 and R6 may be the same or different and each represent a protective group of a hydroxyl group; (2) reacting the compound represented by the general formula [IV] with a hydrazinediol derivative acid addition salt represented by the general formula [III]: wherein, X represents an acid molecule, and R7 and R8 may be the same or different and each represent a hydrogen atom or a protective group of a hydroxyl group, in the presence of an acid-capturing agent to obtain a compound represented by the general formula [II]: wherein, R1, R2, R3, R4, R5 and R6 may be the same or different and each represent a protective group of a hydroxyl group, and R7 and R8 may be the same or different and each represent a hydrogen atom or a protective group of a hydroxyl group; and (3) removing the protective groups of the compound represented by the general formula [II].