Patent ID: 7258853
Filing Date: 2007-08-21
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
1. A method of suppressing an immune response in a patient who has rheumatoid arthritis, the method comprising: administering to the patient a chimeric polypeptide comprising a mutant interleukin-15 (IL-15) polypeptide and a polypeptide that increases the circulating half-life of the mutant IL-15 polypeptide, wherein the mutant IL-15 polypeptide comprises a mutation at position 149 and a mutation at position 156 of SEQ ID NO:6 and the amount of the polypeptide administered is sufficient to compete with wild type IL-15 for binding to an IL-15 receptor complex and thereby suppresses the immune response in the patient.