Patent ID: 6316491
Filing Date: 2001-11-13
Classification: C07D

Abstract:
A radicicol derivative represented by formula (I) or a pharmacologically acceptable salt thereof: ##STR104##wherein R.sup.1 and R.sup.2 independently represent hydrogen, alkanoyl, alkenoyl, tert-butylidiphenylsilyl or tert-butyldimethylsilyl;R.sup.3 represents (A) Y--R.sup.5 wherein Y represents substituted or unsubstituted alkylene; and R.sup.5 represents (a) substituted or unsubstituted pyrrolidonyl, or (b) substituted or unsubstituted pyrrolidinyl,(B) COR.sup.13 wherein R.sup.13 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, substituted or unsubstituted aryl, substituted or unsubstituted lower alkoxy, or NR.sup.14 R.sup.15 (wherein R.sup.14 and R.sup.15 independently represent hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, substituted or unsubstituted aryl, or R.sup.14 and R.sup.15 are combined together with adjoining N to represent a substituted or unsubstituted heterocyclic group), or(C) substituted or unsubstituted aryl;X represents halogen; andR.sup.4 represents hydrogen, alkanoyl, alkenoyl, or --SO--Z (wherein Z is represented by formula (A): ##STR105##wherein R.sup.1A and R.sup.2A have the same meaning as R.sup.1 and R.sup.2, respectively; X.sup.A represents halogen; and W represents O or N--O--R.sup.3A wherein R.sup.3A has the same meaning as R.sup.3), or X and R.sup.4 are combined to represent a single bond.