Patent ID: 8377983
Filing Date: 2013-02-19
Classification: A61P,C07D

Abstract:
1. A method for inhibiting Aurora kinase activity comprising contacting a cell in a subject in which inhibition of Aurora kinase A or B is desired with a compound, wherein the compound is selected from the group consisting of: 4-[6-(1H-Indazol-6-ylcarbamoyl)-2-(2-trifluoromethylphenylamino)-3H-benzimidazol-5-yl]-piperazine-1-carboxylic acid tert-butyl ester, 6-piperazin-1-yl-2-(2-trifluoromethylphenylamino)-1H-benzimidazole-5-carboxylic acid (1H-indazol-6-yl)-amide, 4-[6-(1H-Indazol-6-ylcarbamoyl)-2-(3-methylpyridin-2-ylamino)-3H-benzimidazol-5-yl]-piperazine-1-carboxylic acid tert-butyl ester, 2-(3-Methylpyridin-2-ylamino)-6-piperazin-1-yl-1H-benzimidazole-5-carboxylic acid (1H-indazol-6-yl)-amide, and 6-Diethylamino-2-(2-trifluoromethyl-phenylamino)-1H-benzimidazole-5-carboxylic acid (1H-indazol-6-yl)-amide, or a pharmaceutically acceptable salt thereof.