Patent ID: 6780986
Filing Date: 2004-08-24
Classification: A61K,C07K,C12N

Abstract:
An isolated nucleic acid molecule, comprising a nucleic acid molecule selected from the group consisting of(a) a nucleic acid molecule which hybridizes under stringent conditions to a molecule consisting of a nucleic acid of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:50 and which codes for a polypeptide having a RIP60 activity selected from the group consisting of DNA binding, protein multimerization, and nucleic acid looping, (b) a nucleic acid molecule that differs from the nucleic acid molecule of (a) in codon sequence due to the degeneracy of the genetic code, and (c) complements of (a) or (b), wherein the stringent conditions are hybridization at 65Â° C. in hybridization buffer (3.5Ã—SSC, 0.02% Ficoll, 0.02% polyvinyl pyrolidone, 0.02% Bovine Serum Albumin, 2.5 mM NaH2PO4(pH7), 0.5% SDS, 2 mM EDTA); wherein SSC is 0.1 5M sodium chloride/0.015M sodium citrate, pH7; SDS is sodium dodecyl sulphate; and EDTA is ethylenediaminetetracetic acid.