Patent ID: 8377884
Filing Date: 2013-02-19
Classification: A61K,A61P,C07K

Abstract:
1. A variant of C-type natriuretic peptide (CNP) having a total mass in the range from about 2.6 kDa to about 7.0 kDa, and having the formula: (x) is an amino acid sequence comprising from 1 to 40 amino acids and is optionally conjugated with a PEG polymer or a derivative thereof at the N-terminus of the variant; and (z) may be absent or may be selected from the group consisting of bone- or cartilage-targeting moieties; moieties that reduce renal clearance; hydrophilic polymers; amino acid sequences comprising one or more amino acids; carbohydrates; hydrophobic acids; and combinations thereof.