Patent ID: 8846873
Filing Date: 2014-09-30
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal human antibody that specifically binds GPNMB comprising a combination of a variable heavy chain and a variable light chain selected from the group consisting of: (a) the variable heavy chain amino acid sequence of: SEQ ID NO:20, and the variable light chain amino acid sequence of SEQ ID NO: 29; (b) the variable heavy chain amino acid sequence of SEQ ID NO:74 and the variable light chain amino acid sequence of SEQ ID NO: 83; (c) the variable heavy chain amino acid sequence of SEQ ID NO: 164 and the variable light chain amino acid sequence of SEQ ID NO: 173; (d) the variable heavy chain amino acid sequence of SEQ ID NO: 38 and the variable light chain amino acid sequence of SEQ ID NO: 47; and (e) the variable heavy chain amino acid sequence of SEQ ID NO: 310 and the variable light chain amino acid sequence of SEQ ID NO: 319.