Patent ID: 8980541
Filing Date: 2015-03-17
Classification: A01N,Y10S

Abstract:
1. A method of perfusing an organ, tissue, or part thereof, of an animal or human, the method comprising: (1) evaluating the organ, tissue, or part thereof; and (2) perfusing the organ, tissue, or part thereof at normothermia by recirculation with a solution; wherein the solution comprises: (a) a colloidosmotically active substance that is too large to pass out through semipermeable capillary walls of the animal or human and that is present at a concentration that provides the oncotic pressure of serum albumin at a concentration of 55-105 g/L; (b) a scavenger and coating compound, which coats the capillary endothelium of the organ, tissue, or parts thereof, at a concentration of 1-55 g/L; (c) a physiological serum concentration of a salt; and (d) a nutrient for the organ, tissue, or part thereof, in a physiologically acceptable medium; and further wherein the evaluating comprises measuring evaluation parameters of the organ, tissue, or part thereof for transplantation thereof; the solution provides an oncotic pressure higher than an applied hydrostatic pressure in the organ, tissue, or part thereof, and prevents oedema formation; and the organ, tissue, or part thereof is connected to a heart-lung machine during the perfusion.