Patent ID: 7507730
Filing Date: 2009-03-24
Classification: A61P,C07D

Abstract:
1. A compound having the structure or stereoisomers thereof or a phannaceutically acceptable salt thereof, wherein Q is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, or which is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R R where R 8 is aryl, substituted aryl, carbocyclo, substituted carbocyclo, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkyl, substituted alkyl, heterocyclo, or substituted heterocyclo; and R and wherein R 8 and R 9 together with the atoms to which they are bonded may optionally form a heterocyclic group or a substituted heterocyclic group; R R R wherein the term “substituted alkyl” refers to alkyl groups substituted with one or more groups selected from alkyl, aryl (optionally substituted), substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, arylalkoxy (optionally substituted), alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, and sulfonyl; the term “substituted alkenyl” refers to alkenyl groups substituted with one or more groups selected from alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, and sulfonyl; the term “substituted alkynyl” refers to alkynyl groups substituted with one or more groups selected from alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, and sulfonyl; the term “substituted aryl” refers to aryl groups substituted with one or more groups selected from alkyl, substituted alkyl, alkenyl (optionally substituted), aryl (optionally substituted), heterocyclo (optionally substituted), halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkanoyl (optionally substituted), aroyl, (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, and sulfonyl, where optionally one or more pair of substituents may together with the atoms to which they are bonded form a 3 to 7 member ring; the terms “substituted carbocyclo”, “substituted cycloalky” and “refer to cycloalkyl groups ” refer to cycloalkyl groups and cycloalkenyl groups substituted with one or more groups selected from alkyl, substututed alkyl, aryl substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, and sulfonyl; and the terms “substituted heterocyclo” , “substituted cycloheteroalkyl” and “substituted heteroaryl” refer to heterocyclo, cycloheteroalkyl and heteroaryl groups, respectively, substituted with one or more groups selected from alkyl, substituted alkyl, alkenyl, oxo aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo (optionally substituted), halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), cyano, nitro, amido, amino, substituted amino, lactam, urea, urethane, and sulfonyl, where optionally one or more pair of substituents together with the atoms to which they are bonded form a 3 to 7 member ring.