Patent ID: 6593360
Filing Date: 2003-07-15
Classification: A61P,C07H

Abstract:
A compound of formula (I), or its pharmaceutically acceptable addition salts with inorganic or organic acids or hydrates thereof, whereinA stands for NH group and B simultaneously stands for C&boxH;O group, or A stands for C&boxH;O group and B simultaneously stands for NH group, R1 stands for OH group, L-cladinosyl group of formula (II), R1 stands for a group of formula (III), â€ƒwherein Y stands for hydrogen, C1-C6 alkyl, C1-C6 alkyl group with at least one incorporated O, N or S atom or Y stands for (CH2)nâ€”Ar, wherein (CH2)n stands for alkyl and n is 1-10, with or without incorporated O, N or S atoms, and Ar stands for a 5-10-membered monocyclic or bicyclic aromatic ring containing 0-3 O, N or S atoms, which is unsubstituted or substituted with 1-3 groups representing halogen, OH, OMe, NO2, NH2, amino-C1-C3 alkyl or amino-C1-C3 dialkyl, CN, SO2NH2, C1-C3 alkyl, or R1 together with R2 stands for oxo, R2 stands for hydrogen or together with R1 stands for oxo, R3 stands for hydrogen or C1-C4 alkanoyl group, R4 stands for hydrogen or together with R5 stands for oxo, R5 stands for OH, NH2, amino-C1-C3 alkyl or amino-C1-C3 dialkyl, O(CH2)nAr or S(CH2)nAr, wherein (CH2)n and Ar have the above meanings, or together with R4 stands for oxo, with proviso that when R5 stands for OH, R1 does not stand for L-cladinosyl group of formula (II) or OH, R6 stands for hydrogen, C1-C6 alkyl, hetero C1-C6 alkyl group wherein said hetero atom is O, N or S, or (CH2)nâ€”Ar group, wherein (CH2)n and Ar have the above meanings, with proviso that when R6 stands for H, R1 does not stand for L-cladinosyl group of formula (II) or OH, or R5 and R6 together with intervening atoms form an additional ring of formula (IV) â€ƒwherein Z stands for CH2, C&boxH;O, C(NH), SO, SO2, CH2CO, COCH2, CH2CH2CO, COCH2CH2 or CH2CH2, and X stands for hydrogen, C1-C3 alkyl, NH2, amino-C1-C3 alkyl or amino-C1-C3 dialkyl or (CH2)nâ€”Ar group, wherein (CH2)n and Ar have the above meanings.