Patent ID: 7227019
Filing Date: 2007-06-05
Classification: A61P,C07D,C07H

Abstract:
1. A method for making an indolopyrrolocarbazole compound according to general formula [I]: wherein: independently selected X′ 1 and X″ 1 are at each of the 1-4 and 8-11 positions, respectively, and are selected from H, halogen, OH, —CN, CF 3 , —COR′ a , NO 2 , OR″, O(CH 2 ) n NR′ 9 R″ 10 , O(CH 2 ) n OR″ 9 and O(CH 2 ) n COOR″ 9 ; n is an integer of from 0 to 4; R″ R″ R″ R″ R″ 6 is H, C 1-7 alkyl, aryl, arylalkyl, OR″ 10 , NR″ 9 R″ 10 , or OCO(CH 2 ) n NR″ 9 R″ 10 , said C 1-7 alkyl being optionally substituted with one to six of the same or different halogen, NR″ 9 R″ 10 , CN, NO 2 , aryl, said aryl being substituted with one or two groups independently selected from NR″ 9 R″ 10 , OH, COOR″ 9 , SO 3 R″ 9 or OCOR″ 9 ; and R″ 7 and R″ 8 are each independently H, OH, or taken together is O; the method comprising the step of: reacting a bisindolylmaleimide compound of the general formula [II]: wherein X′ 1 , X″ 1 , R″ 6 , R″ 7 and R″ 8 are as described above in formula [I], with an oxidizing agent while sparging with an oxygen containing gas at a temperature and for a time sufficient to yield the indolopyrrolocarbazole compound of the general formula [I].