Patent ID: 6953812
Filing Date: 2005-10-11
Classification: C07C,C07D

Abstract:
1. A method for treating a subject having Type 2 diabetes, said method comprising administering to said subject an effective amount of a compound of formula wherein R 1 , R 2 , R 3 , R 4 and R 5 independently are hydrogen or C 1-6 -alkyl, A is —C(O)—, —CH(OR 6 )— or —CHF—, wherein R 6 is hydrogen or C 1-6 -alkyl, Z is arylene or a divalent radical derived form a 5 or 6 membered heteroaromatic ring containing 1 or 2 heteroatoms selected from nitrogen, oxygen and sulfur, which may optionally be substituted with one or two groups R wherein R X is wherein r is 0 or 1, q and s independently are 0, 1, 2 or 3, R 11 , R 12 , R 13 and R 14 independently are hydrogen, C 1-6 -alkyl or C 3-8 -cycloalkyl, D is wherein R 15 , R 16 , R 17 and R 18 independently are hydrogen, halogen, —CN, —CHF C C or two of the groups R 15 to R 18 when placed in adjacent positions together may form a bridge —(CR 23 R 24 ) a —O—(CR 25 R 26 ) c —O—, wherein a is 0, 1 or 2, c is 1 or 2, R 23 , R 24 , R 25 and R 26 independently are hydrogen, C 1-6 -alkyl or fluorine, R 19 and R 23 independently are hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkyl-C 1-6 -alkyl, wherein R 27 and R 28 independently are hydrogen, halogen, —CN, —CF 3 , —OR 32 , —NR 32 R 33 , C 1-6 -alkyl, C 3-8 -cycloalkyl, C 4-8 -cycloalkenyl or aryl, wherein the aryl group optionally may be substituted with one or more substituents selected from halogen, —CN, —CF 3 , —NO 2 , —NO 2 , —OR 32 , —NR 32 R 33 and C 1-6 -alkyl, wherein R 32 and R 33 independently are hydrogen or C 1-6 -alkyl, or R 32 and R 33 when attached to the same nitrogen atom together with the said nitrogen atom may form a 3 to 8 membered heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulfur, and optionally containing one or two double bonds, R 29 , R 30 and R 31 independently are hydrogen, halogen, —CHF C C or two of the groups R 29 , R 30 and R 31 when attached to the same ring carbon atom or different ring carbon atoms together may form a radical —O—(CH 2 ) t —CR 36 R 37 —(CH 2 ) t —O—, —(CH 2 ) t —CR 36 R 37 —(CH 2 ) t — or —S—(CH 2 ) t —CR 36 R 37 —(CH 2 ) t —S—, wherein t and l independently are 0, 1, 2, 3, 4 or 5, R 36 and R 37 independently are hydrogen or C 1-6 -alkyl, as well as any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.