Patent ID: 8321148
Filing Date: 2012-11-27
Classification: G16B

Abstract:
1. A method for modeling a dosing regimen for a medicament, the method comprising: providing a system including at least two biocompartments selected from the group consisting of intracellular and extracellular regions; determining, by a processing device, steady state levels in each of said at least two biocompartments by assigning variables to represent a protein production rate of at least one protein in one of said at least two biocompartments, a degradation rate constant of said at least one protein for each of said at least two biocompartments, and a transport rate constant of said at least one protein between said at least two biocompartments using a set of equations; modifying, by the processing device, values of said assigned variables in said set of equations to use said set of equations to calculate an amount of said at least one protein in one of said at least two biocompartments to which said at least one protein is being transported, as a function of time, said set of equations reflecting selected characteristics of said at least one protein and one or more drug pulse parameters, said one or more drug pulse parameters include a start time, a duration, an interval time, a number of pulses, an amount of drug, and a number of times settings are repeated; calculating, by the processing device, a weighted value of said at least one protein in said one of said at least two biocompartments to which said at least one protein is being transported, wherein said weighted value is a result of multiplying a calculated factor by an amount of said at least one protein in said one of said at least two biocompartments to which said at least one protein is being transported, said calculated factor being determined using a drug concentration pulse curve and a set of input parameters including a substrate concentration, a maximum drug concentration, a rise time, and a drug elimination half-life, said drug concentration pulse curve and said set of input parameters associated with a drug; integrating, by the processing device, said weighted value over a time period to determine a weighted area-under a curve associated with said integrating said weighted value; calculating, by the processing device, a non-drug value of said at least one protein in said one of said at two biocompartments to which said at least one protein is being transported, wherein said non-drug value is an amount of said at least one protein in said one of said at least two biocompartments to which said at least one protein is being transported without addition of said drug; integrating, by the processing device, said non-drug value over said time period to find a non-drug area under a curve associated with said integrating of said non-drug value; and evaluating, by the processing device, one or more dosing regimens by comparing said weighted area and said non-drug area of said at least one protein in said one of said at least two biocompartments to which said at least one protein is being transported over said time period to determine a net effect of said drug over said time period.