Patent ID: 7566734
Filing Date: 2009-07-28
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-N-cyclohexylamine; N-{1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)heptyl}cyclohexanamine; (4-phenyl-1H-imidazol-2-yl)methanamine; (1S)-3-methyl-1-(4-phenyl-1H-imidazol-2-yl)-1-butanamine; (1R)-N-benzyl-2-phenyl-1-(4-phenyl-1H-imidazol-2-yl)ethanamine; N-benzyl(4-phenyl-1H-imidazol-2-yl)methanamine; tert-butyl (R,S)-1-(4-phenyl-1H-imidazol-2-yl)heptylcarbamate; (4-(1,1′-biphenyl)-4-yl-1-methyl-1H-imidazol-2-yl)methanamine; (R,S)-N-benzyl-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-1-heptanamine; N-benzyl-N-((4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)methyl)-1-hexanamine; N-benzyl(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-N-methylmethanamine; (R,S)-4-(2-{1-((tert-butoxycarbonyl)amino)pentyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (R,S)-N-benzyl-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-pentanamine; (R,S)-N,N-dihexyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; tert-butyl (R,S)-1-(4-phenyl-1H-imidazol-2-yl)hexylcarbamate; (R,S)-N-hexyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-1-(4-phenyl-1H-imidazol-2-yl)hexylamine; (R,S)-N-benzyl-1-(4-(4-methoxyphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-(2,6-dichlorobenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-(4-chlorobenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-1-(4-(3-methoxyphenyl)-1H-imidazol-2-yl)heptylamine; (R,S)-N-(2-chlorobenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-(2-fluorobenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-butyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-isopentyl-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)amine; (R,S)-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-N-hexyl-1-heptanamine; (R,S)-N-pentyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)cyclohexanamine; (R,S)-N-benzyl-1-(4-(3,4-dichlorophenyl)-1H-imidazol-2-yl)-1-heptanamine; butyl (4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)methylcarbamate; (R,S)-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)cyclopentanamine; (R,S)-N-{1-(4-(2-chlorophenyl)-1H-imidazol-2-yl)heptyl}-cyclohexanamine; (R,S)-N-{1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)heptyl}-cyclobutanamine; (R,S)-2-phenyl-1-(4-phenyl-1H-imidazol-2-yl)ethanamine; tert-butyl (4-phenyl-1H-imidazol-2-yl)methylcarbamate; tert-butyl (1-benzyl-4-phenyl-1H-imidazol-2-yl)methylcarbamate; (1-benzyl-4-phenyl-1H-imidazol-2-yl)methanamine; N-benzyl(1-benzyl-4-phenyl-1H-imidazol-2-yl)methanamine; (1R)-2-(1-benzothien-3-yl)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)ethanamine; tert-butyl (1R)-3-methyl-1-(4-phenyl-1H-imidazol-2-yl)butylcarbamate; (1R)-N-benzyl-3-methyl-1-(4-phenyl-1H-imidazol-2-yl)-1-butanamine; tert-butyl (R,S)-phenyl(4-phenyl-1H-imidazol-2-yl)methylcarbamate; (R,S)-phenyl(4-phenyl-1H-imidazol-2-yl)methylamine; tert-butyl (1R)-3-phenyl-1-(4-phenyl-1H-imidazol-2-yl)-propylcarbamate; (1R)-3-phenyl-1-(4-phenyl-1H-imidazol-2-yl)-1-propanamine; (R,S)-N-benzyl(phenyl)(4-phenyl-1H-imidazol-2-yl)methanamine; (1R)-N-benzyl-3-phenyl-1-(4-phenyl-1H-imidazol-2-yl)-1-propanamine; 4-(2-{((tert-butoxycarbonyl)amino)methyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (1-benzyl-4-phenyl-1H-imidazol-2-yl)-N,N-dimethylmethanamine; 4-(1-benzyl-2-{((tert-butoxycarbonyl)amino)methyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)methanamine; (R,S) 1-(4-phenyl-1H-imidazol-2-yl)heptylamine; (1-benzyl-4(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)methanamine; (R,S)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; 4-(2-{((tert-butoxycarbonyl)amino)methyl}-1-methyl-1H-imidazol-4-yl)-1,1′-biphenyl; 4-(2-{((tert-butoxycarbonyl)(methyl)amino)methyl}-1H-imidazol-4-yl)-1,1′-biphenyl; tert-butyl methyl((5-methyl-4-phenyl-1H-imidazol-2-yl)-methyl)carbamate; (4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-N-methylmethanamine; N-methyl-(5-methyl-4-phenyl-1H-imidazol-2-yl)methanamine; 4-(2-{(benzyl(tert-butoxycarbonyl)amino)methyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (1R)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-3-phenyl-1-propanamine; N-benzyl(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)methanamine; (1R)-N-benzyl-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-3-phenyl-1-propanamine; tert-butyl (R,S)-1-(4-phenyl-1H-imidazol-2-yl)pentylcarbamate; (R,S)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-pentanamine; (R,S)-1-(4-phenyl-1H-imidazol-2-yl)pentylamine; tert-butyl (R,S)-1-(4-(4-methylphenyl)-1H-imidazol-2-yl)-heptylcarbamate; tert-butyl (R,S)-1-(4-(2-methoxyphenyl)-1H-imidazol-2-yl)-heptylcarbamate; (R,S)-1-(4-(4-methylphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-1-(4-(2-methoxyphenyl)-1H-imidazol-2-yl)heptylamine; (R,S)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)-1-pentanamine; tert-butyl (R,S)-1-(4-(4-methoxyphenyl)-1H-imidazol-2-yl)heptylcarbamate; (R,S)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-heptanamine; tert-butyl (R,S)-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-heptylcarbamate; (R,S)-1-(4-(4-methoxyphenyl)-1H-imidazol-2-yl)heptylamine; (R,S)-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-4-(2-{1-((tert-butoxycarbonyl)amino)heptyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (R,S)-N-benzyl-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-1-heptanamine; 4-(2-{(1S)-1-((tert-butoxycarbonyl)amino)propyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (R,S)-N-benzyl-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-heptanamine; (1S)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-propanamine; (1S)-N-benzyl-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-propanamine; (R,S)-N-benzyl-1-(4-(4-methylphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-(2-methoxyphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)-1-hexanamine; (R,S)-4-(2-(1-aminoheptyl)-1H-imidazol-4-yl)benzonitrile; (R,S)-1-(4-(4-bromophenyl)-1H-imidazol-2-yl)-1-heptanamine; tert-butyl (1R)-1-(4-phenyl-1H-imidazol-2-yl)butylcarbamate; 4-(2-{(1R)-1-((tert-butoxycarbonyl)amino)butyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (1R)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-butanamine; (R,S)-4-(2-(1-aminoheptyl)-1H-imidazol-4-yl)-2,6-di(tert-butyl)-phenol; (1R)-1-(4-phenyl-1H-imidazol-2-yl)-1-butanamine; (R,S)-N-benzyl-1-(4-(4-bromophenyl)-1H-imidazol-2-yl)-1-heptanamine; (1R)-N-benzyl-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)-1-butanamine; (1R)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)-1-butanamine; (R,S)-N-(3-chlorobenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-(3-methoxyphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-4-{2-(1-(benzylamino)heptyl)-1H-imidazol-4-yl}benzonitrile; (R,S)-4-(2-(1-aminoheptyl)-1H-imidazol-4-yl)-N,N-diethylaniline; (1R)-1-(4-phenyl-1H-imidazol-2-yl)ethanamine; (R,S)-1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-1-(4-(2-chlorophenyl)-1H-imidazol-2-yl)-1-heptanamine; N-((1S)-1-(4-(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)propyl)-1-butanamine; (1R)-N-benzyl-1-(4-phenyl-1H-imidazol-2-yl)ethanamine; (R,S)-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)-N-propylamine; (R,S)-N-benzyl-1-(4-(3-methoxyphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-4-{2-(1-(benzylamino)heptyl)-1H-imidazol-4-yl}benzonitrile; (R,S)-N-(4-methoxybenzyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-(2-chlorophenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-N-(1-{4-(4-(diethylamino)phenyl)-1H-imidazol-2-yl}heptyl)amine; (R,S)-1-(4-(3,4-dichlorophenyl)-1H-imidazol-2-yl)-1-heptanamine; tert-butyl (R,S)-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexylcarbamate; (R,S)-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methyl-1-hexanamine; (R,S)-N-isobutyl-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-benzyl-1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methyl-1-hexanamine; (R,S)-N-benzyl-1-(4-(4-methoxyphenyl)-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)cyclobutanamine; 4-(2-{(1S)-1-((butoxycarbonyl)amino)ethyl}-1H-imidazol-4-yl)-1,1′-biphenyl; 4-(2-{(1R)-1-((butoxycarbonyl)amino)ethyl}-1H-imidazol-4-yl)-1,1′-biphenyl; (R,S)-N-isopropyl-N-(1-(4-phenyl-1H-imidazol-2-yl)heptyl)amine; (R,S)-N-{1-(4-(3,4-dichlorophenyl)-1H-imidazol-2-yl)heptyl}-cyclohexanamine; (R,S)-N-(1-(4(1,1′-biphenyl)-4-yl-1H-imidazol-2-yl)heptyl)-cyclohexanamine; N-{(4-(3-bromophenyl)-1H-imidazol-2-yl)methyl}cyclohexanamine; (R,S)-N-{1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-4-methylpentyl}-cyclohexanamine; (R,S)-N-(cyclohexylmethyl)-1-(4-phenyl-1H-imidazol-2-yl)-1-heptanamine; (R,S)-N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-cyclohexanamine; and N-{(1R)-1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-methylpropyl}-cyclohexanamine; or a pharmaceutically acceptable salt thereof.