Patent ID: 8158637
Filing Date: 2012-04-17
Classification: A61P,C07D

Abstract:
1. A compound of formula IA or formula IB: or a pharmaceutically acceptable salt or derivative thereof, wherein: z is 0-3; R wherein up to two methylene units in R x and y, each, is independently 0-4; W is halo, —OR wherein: each of w each M is independently selected from hydrogen, Li, Na, K, Mg, Ca, Ba, —N(R n is 0-2; M′ is H, —C each occurrence of R each occurrence of R is independently hydrogen or C provided that the following compounds are excluded: carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, phenylmethyl ester; carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, phenylmethyl ester, monohydrochloride; carbamic acid, [(3S)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; carbamic acid, [(3R)-1-[6-fluoro-2-(2-hydroxyphenyl)-4-quinazolinyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; carbamic acid, [(3R)-1-[2-(2-fluoro-6-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 3-pyridinylmethyl ester, trifluoroacetate (salt); carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 4-pyridinylmethyl ester, trifluoroacetate (salt); carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, 1,3-benzodioxol-4-ylmethyl ester, trifluoroacetate (salt); carbamic acid, [(3R)-1-[6-fluoro-2-(2-hydroxyphenyl)-4-quinazolinyl]-3-pyrrolidinyl]-, (tetrahydro-2H-pyran-2-yl)methyl ester, trifluoroacetate (salt); and carbamic acid, [(3R)-1-[2-(2-hydroxyphenyl)-7-methyl-4-quinazolinyl]-3-pyrrolidinyl]-, (tetrahydro-2H-pyran-2-yl)methyl ester.