Patent ID: 6255487
Filing Date: 2001-07-03
Classification: C07D

Abstract:
A process for the preparation of compounds of the formula ##STR11##wherein R.sub.1 represents a --CONH.sub.2, --CN, --COOH, --COOM or --COOR.sub.3 group, M being an alkali metal and R.sub.3 being an alkyl radical having from 1 to 4 carbon atoms, and X.sub.1 and X.sub.2 independently represent a hydrogen, fluorine, chlorine and/or bromine atom, which comprises reacting a substituted [2-(1-piperazinyl)ethoxy]methyl compound of the formula ##STR12##in whichR.sub.1 represents a --CONH.sub.2, --CN, --COOH, --COOM or --COOR.sub.3 group, M being an alkali metal and R.sub.3 being an alkyl radical having from 1 to 4 carbon atoms, andR.sub.2 represents a hydrogen atom, with a diphenylmethyl halide of the formula ##STR13##in which X' represents a halogen atom selected from chlorine, bromine or iodine and X.sub.1 and X.sub.2 independently represent a hydrogen, fluorine, chlorine and/or bromine atom.