Patent ID: 6051593
Filing Date: 2000-04-18
Classification: C07D

Abstract:
A compound having the chemical structure: ##STR4## wherein: A and B are selected from the groups consisting of carbon, nitrogen, oxygen and sulfur such that, when B is carbon, A is selected from the group consisting of nitrogen, oxygen and sulfur and when B is nitrogen, A is also nitrogen wherein,when A and B are both nitrogen, R.sup.7 is bonded to whichever of A or B is not participating in one of the heteroaryl ring double bonds;Z is selected from the group consisting of oxygen, sulfur and --NR.sup.12 wherein,R.sup.12 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, carbonyl, C-carboxyl, O-carboxyl, C-amido, guanyl, sulfonyl and trihalomethanesulfonyl;R.sup.1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, pyrrole, imidazole, pyrazole, furan, thiophene, hydroxy, alkoxy, trihalomethanecarbonyl, sulfonyl, trihalomethanesulfonyl, C-carboxyl, O-carboxyl, C-amido, and guanyl;R.sup.2 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and halogen;n is 0 or 1;R.sup.3, R.sup.3', R.sup.4, R.sup.4', R.sup.5, R.sup.5', R.sup.6 and R.sup.6' are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, pyrrole, imidazole, pyrazole, furan, thiophene, alkoxy, aryloxy, thioalkoxy, thioaryloxy, heteroaryloxy wherein the heteroaryl moiety of said heteroaryloxy is selected from the group consisting of pyrrole, imidazole, pyrazole, furan, or thiophene, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethanesulfonyl, carbonyl, C-carboxyl, O-carboxyl, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, phosphonyl, N-thiocarbamyl, guanyl, guanidino, ureido, amino, trihalomethanesulfonamido, and --NR.sup.13 R.sup.14 ; wherein,R.sup.13 and R.sup.14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a pyrrole, pyrazole or imidazole ring;When any of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are hydrogen, R.sup.3', R.sup.4', R.sup.5' and R.sup.6', respectively, in addition to being independently selected from the above group, may be independently selected from the group consisting of hydroxy and thiohydroxy;Combined, R.sup.3 and R.sup.3', R.sup.4 and R.sup.4', R.sup.5 and R.sup.5' and R.sup.6 and R.sup.6' may be independently selected from the group consisting of keto, five-member spirocycloalkyl or six-member spirocycloalkyl;R.sup.7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, trihalomethanecarbonyl, alkenyl, alkynyl, aryl, pyrrole, imidazole, pyrazole, furan, thiophene, C-carboxy, O-carboxy, c-amido, halo, cyano, hydroxy, alkoxy, sulfonyl and trihalomethanesulfonyl;R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, alkenyl, alkynyl, cycloalkyl, aryl, pyrrole, imidazole, pyrazole, furan, thiophene, hydroxy, alkoxy, cycloalkoxy, aryloxy, heteroaryloxy wherein the heteroaryl moiety of said heteroaryloxy group is selected from the group consisting of pyrrole, imidazole, pyrazole, furan or thiophene, thiohydroxy, thioalkyoxy, thiocycloalkoxy, thioheteroaryloxy wherein the heteroaryl moiety of said thioheteroaryloxy group is selected from the group consisting of pyrrole, imidazole, pyrazole, furan or thiophene, halo, nitro, cyano, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, silyl, phosphonyl, C-carboxy, O-carboxy, N-amido, C-amido, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethanesulfonyl, guanyl, guanidino, trihalomethanesulfonamido, amino and --NR.sup.13 R.sup.14, wherein,R.sup.13 and R.sup.14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a pyrrole, imidazole or pyrazole ring,and physiologically acceptable salts and prodrugs thereof.