Patent ID: 7897729
Filing Date: 2011-03-01
Classification: A61K,A61P,C07K

Abstract:
1. A polypeptide consisting of a dimer of a first amino acid chain and a second amino acid chain, which can be the same or different, and where each amino acid chain comprises: a first region comprising a protein or portion thereof; a second region comprising two to six copies of at least a portion of an HCH2 region of a first mammalian IgG, where the HCH2 region comprises a hinge of the first mammalian IgG and a CH2 of the first mammalian IgG; and a third region comprising a hinge of a second mammalian IgG, a CH2 of the second mammalian IgG, and a CH3 of the second mammalian IgG; wherein (1) one or more cysteines of the hinge of the HCH2 region of one or both amino acid chains is mutated to an amino acid selected from the group consisting of serine, alanine, glycine, and threonine, (2) the first mammalian IgG and the second mammalian IgG are from the same mammal, and (3) the polypeptide targets to cells expressing a low affinity FcγR or binds to a low affinity FcγR.