Patent ID: 8153151
Filing Date: 2012-04-10
Classification: A61K

Abstract:
1. A method of selectively controlling transdermal drug delivery, comprising topically administering at least one drug in a flexible, finite matrix, said matrix comprising a blend of: (i) at least one first silicone-based polymer, said first silicone-based polymer having a silicone-bonded hydroxyl content below about 13,000; (ii) at least one second silicone-based polymer, said second silicone-based polymer having silicone-bonded hydroxyl content of greater than about 13,000, and (iii) at least one drug present in an amount sufficient to achieve kinetics resulting in blood levels of drug that is approximately constant once steady state is attained, wherein the relative amounts of said at least one first silicone-based polymer and said at least one second silicone-based polymer are selected to control the onset and rate of delivery.