Patent ID: 6348624
Filing Date: 2002-02-19
Classification: C07C,Y02P

Abstract:
A process for making 2,4-difluoro-3-Q1-benzoic acid: wherein Q1 is derived from an electrophilic reagent, comprising the steps of:(a) treating 1-bromo-2,4-difluorobenzene: â€ƒwith a strong, non-nucleophilic base; then treating with an electrophilic reagent which provides Q1, or a functional moiety which is then transformed to Q1, producing 1-bromo-2,4-difluoro-3-Q1-benzene: (b) treating the 1-bromo-2,4-difluoro-3-Q1-benzene with an alkali or alkaline earth metal or organometallic reagent; then treating with carbon dioxide, or with a formylating agent followed by oxidation, to produce 2,4-difluoro-3-Q1 -benzoic acid.