Patent ID: 6506764
Filing Date: 2003-01-14
Classification: A61P,C07D

Abstract:
A compound of formula (I)Bâ€”Xâ€”(CH2)mâ€”CR1R2 â€”(CH2)nâ€”COâ€”Yâ€ƒâ€ƒ(I) whereinm+n=1; X is SO2; Y is NHOH; R1 is H, Rx or a group (optionally substituted with Rx) selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl; and R2 is H or C1-6 alkyl; or CR1R2 is cycloalkyl or heterocycloalkyl optionally substituted with Rx; Rx is R3 or a group (optionally substituted with R3) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl; R3 is OR7, OCF3, OCH2F, OCHF2, COR7, CO2R4, CON(R7)2, N(R7)2, NR7COR7, NR7CON(R7)2, NR7CO2R8, NR7SO2R8, S(O)0-2R8, SO2N(R7)2, cycloimidyl (optionally substituted with R5) or, where R3 is not attached to an aryl or heteroaryl group, R3 may also be &boxH;O, &boxH;NOR10 or &boxH;NOH; R4 is H or C1-6 alkyl; R5 is C1-6 alkyl; B is cycloalkyl or cycloalkenyl substituted with a group selected from &boxH;O , &boxH;NOR7 or &boxH;CR6R7, B is heterocycloalkyl or heterocycloalkenyl substituted with &boxH;CR6R7, or B is a spirocyclic system optionally substituted by R3 or R7; R6is H or C1-6 alkyl; R7 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl or C1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R8, COR8, SO0-2R8, CO2R8, OR8, OCF3, OCH2F, OCHF2, CONR4R8, NR6R8 or SO2NR4R8 and for each case of N(R7)2 the R7 groups are the same or different, or N(R7)2 is heterocycloalkyl optionally substituted with R8, COR8, SO0-2R8, CO2R8, OR8, CONR4R8, NR4R8, or SO2NR4R8; and R8 is C1-6 alkyl, aryl, C1-6 alkyl-aryl heteroaryl or C1-6 alkyl-heteroaryl; or the salt, solvate, hydrate, N-oxide, protected amino, protected carboxy or protected hydroxamic acid derivative thereof, or the enantiomeric, diastereomeric, or racemic mixture thereof.