Patent ID: 8080519
Filing Date: 2011-12-20
Classification: A61K,A61P

Abstract:
1. A method of significantly enhancing the bioavailability of pharmaceutical effects of therapeutically active peptides comprising: orally or parentally administering to a patient an effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable adjuvant and a pharmaceutical agent having the general formula: wherein Peptide is a therapeutically active peptide of from 2 to 40 amino acids; wherein Carrier comprises an aryl or alkyl group of sufficient length or steric bulk to inhibit rapid enzymatic degradation of the therapeutically active peptide species and is a member selected from the group consisting of cinnamoyl, benzoyl, phenylacetyl, 3-OH-cinnamoyl, 3,4-OH-cinnamoyl, 3,4-methylenedioxycinnamoyl, 3-methoxycinnamoyl, 3,4-dimethoxycinnamoyl, 3,4,5-trimethoxy-cinnamoyl, t-butoxy-carbonyl, benzyloxycarbonyl, pivaloyl, N-9-fluorenylethoxycarbonyl, fumaroyl, and combinations thereof; and Linker is a member selected from the group consisting of C5 to C16 lipidic chains, 8-amino-3,6-dioxaoctanoic acid, a peptide of less than 4 residues, and combinations thereof; and wherein the pharmaceutical composition is more biologically and/or pharmacologically efficacious compared to administration of the Peptide therapeutically active alone.