Patent ID: 8753610
Filing Date: 2014-06-17
Classification: A61K,A61P,C07K

Abstract:
1. A method of diagnosing a brain disorder comprising detecting a signal emitted by a composition in the central nervous system (CNS) of an individual, wherein the composition comprises a fusion antibody that: (i) comprises a first antibody and a second antibody, wherein the first antibody is an ScFv antibody that is linked to the carboxy terminus of the second antibody; (ii) is capable of crossing the blood-brain barrier (BBB) from the blood to the brain by binding an endogenous receptor of the BBB; (iii) comprises an Fc region that enables crossing the BBB from the brain to the blood by binding to an Fc receptor; and (iv) interacts with a pathological substance associated with the brain disorder, wherein the ScFv retains at least 10% of its affinity compared to the affinity of the tetrameric immunoglobulin from which the ScFv can be derived.