Patent ID: 9138490
Filing Date: 2015-09-22
Classification: A61K,C09B,C12Q,G01N

Abstract:
1. A method for detecting a pathogenic Mycobacteria in real time in a subject or a biological sample, comprising: introducing into a subject or contacting a biological sample therefrom or obtained from a surface with a fluorogenic substrate for a beta-lactamase of the pathogenic Mycobacteria, wherein the fluorogenic substrate is selected from the group consisting of CNIR800-3, XHX2-81, XHX2-91, XHX3-1, XHX3-26 and XHX3-32; imaging the subject or sample for a product from beta-lactamase activity on the substrate; and acquiring signals in real time at a wavelength emitted by the beta-lactamase product, thereby detecting the pathogenic Mycobacteria in the subject or the sample.