Patent ID: 7365068
Filing Date: 2008-04-29
Classification: A61P,C07C,C07D

Abstract:
1. A compound or a pharmaceutically acceptable salt thereof wherein the compound is 1-(3-cyclopropyl-4-(pentyloxy)phenyl)-3-nicotinoylthiourea; methyl 2-oxo-2-(5-((3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thioureido)carbonyl)pyridin-2-ylamino)acetate; methyl 2-(5-((3-(4-(heptyloxy)phenyl)thioureido)carbonyl)pyridin-2-ylamino)-2-oxoacetate; 1-(2-(2-amino-2-oxoacetamido)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-(2-(dimethylamino)ethoxy)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(2-methylnicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-(4-methylpiperazin-1-yl)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(6-(4-methylpiperazin-1-yl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(6-(4-methylpiperazin-1-yl)nicotinoyl)thiourea; 1-(6-(4-methylpiperazin-1-yl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(3-methyl-4-(pentyloxy)phenyl)-3-(6-(4-methylpiperazin-1-yl)nicotinoyl)thiourea; 1-(6-hydroxynicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(6-hydroxynicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(6-hydroxynicotinoyl)thiourea; 1-(6-hydroxynicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(5-hydroxynicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(5-hydroxynicotinoyl)thiourea; 1-(6-(morpholine-4-carbonyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-((dimethylamino)methyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-acetamidonicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; (5-((3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thioureido) carbonyl)pyridin-2-yl)methyl acetate; 1-(6-(hydroxymethyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-(morpholinomethyl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(6-(morpholinomethyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-((dimethylamino)methyl)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(4-(heptyloxy)phenyl)-3-(6-(morpholine-4-carbonyl)nicotinoyl)thiourea; 1-(6-(morpholine-4-carbonyl)nicotinoyl)-3-(4-(octyloxy)phenyl)thiourea; 1-(6-(morpholine-4-carbonyl)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(4-(heptyloxy)phenyl)-3-(6-((4-methylpiperazin-1-yl)methyl)nicotinoyl)thiourea; 1-(6-((4-methylpiperazin-1-yl)methyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-((dimethylamino)methyl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(4-(heptyloxy)phenyl)-3-(6-hydroxynicotinoyl)thiourea; 1-(6-((dimethylamino)methyl)nicotinoyl)-3-(4-(hexyloxy)phenyl)thiourea; 1-(4-(hexyloxy)phenyl)-3-(6-(morpholinomethyl)nicotinoyl)thiourea; 1-(4-(heptyloxy)phenyl)-3-(6-(morpholinomethyl)nicotinoyl) thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(26-morpholinonicotinoyl)thiourea; 1-(6-cyanonicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-cyanonicotinoyl)-3-(3-fluoro-4-(pentyloxy)phenyl)thiourea; 1-(2-cyanonicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(6-(2-morpholinoethoxy)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(26-(2-morpholinoethoxy) nicotinoyl)thiourea; 1-(6-(2-morpholinoethoxy)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(6-(2-morpholinoethoxy)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(6-(dimethylamino)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-(dimethylamino)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(6-(dimethylamino)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-(5-(furan-3-yl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(5-(furan-3-yl)nicotinoyl)thiourea; 1-(5-(furan-3-yl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(3-cyano-4-(pentyloxy)phenyl)-3-nicotinoylthiourea; 1-(5-bromonicotinoyl)-3-(4-(pentyloxy)-3-(trifloromethyl)phenyl)thiourea; 1-(6-(dimethylcarbamoyl)nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(6-(dimethylcarbamoyl)nicotinoyl)-3-(3-fluoro-4-(pentyloxy)phenyl)thiourea; 1-(3-cyano-4-(pentyloxy)phenyl)-3-(6-(dimethylcarbamoyl) nicotinoyl)thiourea; 1-(6-(dimethylcarbamoyl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(3-chloro-4-(pentyloxy)phenyl)-3-(6-cyanonicotinoyl)thiourea; 1-(5-cyanonicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; methyl 5-((3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thioureido)carbonyl)nicotinate; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-(6-(1-methylpiperazine-4-carbonyl)nicotinoyl)thiourea; 1-(3-chloro-4-(pentyloxy)phenyl)-3-(6-(1-methylpiperazine-4-carbonyl)nicotinoyl)thiourea; 1-(6-(1-methylpiperazine-4-carbonyl)nicotinoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(3-chloro-4-(pentyloxy)phenyl)-3-nicotinoylthiourea; 1-(4-(pentyloxy)phenyl)-3-(6-(2-(pyrrolidin-1-yl)ethyl)nicotinoyl)thiourea; 1-(4-pentylphenyl)-3-(6-(2-(pyrrolidin-1-yl)ethyl)nicotinoyl)thiourea; 1-(2-(4-fluorophenoxy)nicotinoyl)-3-(4-pentylphenyl)thiourea; 1-nicotinoyl-3-(4-(octyloxy)phenyl)thiourea; 1-nicotinoyl-3-(4-octylphenyl)thiourea; 1-(4-(hexyloxy)phenyl)-3-nicotinoylthiourea; 1-(4-hexylphenyl)-3-nicotinoylthiourea; 1-(3-fluoro-4-(pentyloxy)phenyl)-3-nicotinoylthiourea; 1-nicotinoyl-3-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiourea; 1-(4-butoxyphenyl)-3-nicotinoylthiourea; 1-(4-(heptyloxy)-3-(trifluoromethyl)phenyl)-3-nicotinoylthiourea; 1-(3-chloro-4-(pentyloxy)phenyl)-3-nicotinoylthiourea; or 1-(4-isopropoxy-3-(trifluoromethyl)phenyl)-3-nicotinoylthiourea.