Patent ID: 6284270
Filing Date: 2001-09-04
Classification: A61K,Y10S

Abstract:
A process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water, said process comprising:dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein said solvent provides high porosity upon drying;spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product;dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the solvent or dissolved mixture, or adding said binding agent to the bulking agent and/or structural agent and/or solvent, thus said binding agent and said active ingredient may optionally be added before said spray-drying or dispersing;compressing said preformulation product to obtain a compressed preformulation product; andsintering said preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow said binding agent to resolidify as the temperature is reduced to ambient temperature of 50.degree. C. to 100.degree. C.