Patent ID: 7238835
Filing Date: 2007-07-03
Classification: C07C,C07D

Abstract:
1. A process for preparing a compound of formula (I) comprising the steps of: a) reacting a compound of formula (II) in the presence of a base B1 with a compound of formula (III) to provide a compound of formula (IV); and b) reacting the compound of formula (IV) in the presence of a base B2 with a compound of formula (V) to provide a compound of formula (I) wherein R is selected from the group consisting of unsubstituted or at least monosubstituted C X X wherein heteroaryl is a 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13- or 14-membered, aromatic, mono-, bi- or tricyclic heterocycle which contains one or more heteroatoms selected from N, O and S; wherein aryl is a 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13- or 14-membered, aromatic mono-, bi- or tricyclic system; wherein heterocyclyl is a 5-, 6-, 7-, 8-, 9-, 10, 11-, 12-, 13- or 14-membered, nonaromatic, mono-, bi- or tricyclic heterocycle which contains one or more heteroatoms selected from N, O and S; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; Y is a leaving group; and B1 is selected from the group consisting of an alkali metal alcoholate, alkaline earth metal alcoholate, silazide or alkali metal hydroxide. B2 is selected from the group consisting of an alkali metal hydroxide, alkaline earth metal hydroxide, alkali metal alcoholate, alkaline earth metal alcoholate, alkali metal hydride, alkaline earth metal hydride, silazide, alkali metal amide or alkaline earth metal amide.