Patent ID: 6576642
Filing Date: 2003-06-10
Classification: A61P,C07C,C07D

Abstract:
A compound having the formula (1): wherein A is phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl, is each optionally substituted with halogen, lower alkoxy, lower alkyhhio, amino which is optionally substituted with 1 or 2 lower alkyl, alkyl which is optionally substituted by 1 to 3 halogen; or lower alkythio;X is a divalent residue of an alicyclic compound, an imino group, an aromatic compound, or a heterocyclic compound, which is optionally substituted, or a sulfur or oxygen atoms; Y is a single bond or lower alkylene; Z is an unsubstituted aliphatic group which comprises â€”CH&boxH;CHâ€”, â€”CRCâ€”, â€”(CH&boxH;CH)2â€”, â€”Câ‰¡Câ€”CH&boxH;CHâ€” or â€”CH&boxH;CHâ€”Câ‰¡Câ€” or a divalent residue of benzene or pyridine which are each optionally substituted by halogen, lower alkyl, lower alkoxy, amino or nitro; and R is hydrogen, lower alkyl of at least two carbon atoms, cycloalkyl, aryl or aralkyl, with the proviso that A is not phenyl or phenyl substituted with lower alkoxy or lower alkyl when Z is â€”CH&boxH;CHâ€”; or a salt or solvate thereof.