Patent ID: 9205143
Filing Date: 2015-12-08
Classification: A61K,A61P

Abstract:
1. A method of immunizing a subject against diseases caused by S. pneumoniae infection comprising administering to said subject: an immunoprotective dose of a vaccine comprising conjugated capsular at least one TLR-9 agonist as an adjuvant, wherein said at least one TLR-9 agonist is a CpG oligonucleotide having the nucleic acid sequence selected from the group consisting of: 5′ TCGTCGTTTTTCGGTGCTTTT 3′ (SEQ ID NO: 3); 5′ TCGTCGTTTTTCGGTCGTTTT 3′ (SEQ ID NO: 4); 5′ TCGTCGTTTTGTCGTTTTGTCGTT 3′ (SEQ ID NO: 5); 5′ TCGTCGTTTCGTCGTTTTGTCGTT 3′ (SEQ ID NO: 6); and 5′ TCGTCGTTTTGTCGTTTTTTTCGA 3′ (SEQ ID NO: 7); and wherein said subject suffers from HIV-infection or acquired immunodeficiency syndrome (AIDS).