Patent ID: 9085807
Filing Date: 2015-07-21
Classification: A61K,A61P,C07K,C12N,C12Q

Abstract:
1. A therapeutic autologous dendritic cell vaccine that elicits an immune response against specific pathogen antigens present in an HIV infected subject comprising a pharmaceutically acceptable carrier and a dendritic cell obtained or derived from said subject, wherein said dendritic cell comprises HIV polypeptides that: a) correspond to multiple allelic variants of at least one polypeptide from multiple strains of HIV present in said subject; b) include less than all of the polypeptides from any of said HIV strains; and c) comprise truncated vpr polypeptides encoded by nucleic acids amplified from said subject using a vpr forward primer comprising the sequence set forth in SEQ ID NO:57 and/or 58 and a vpr reverse primer having the sequence set forth in SEQ ID NO:269, 270, 271, 272, and/or 273.