Patent ID: 9150644
Filing Date: 2015-10-06
Classification: A61K,C07K,G01N

Abstract:
1. An isolated human monoclonal antibody, or antigen binding fragment thereof, wherein the monoclonal antibody or antigen binding fragment comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises the amino acid sequence set forth as amino acids 26-33 of SEQ ID NO: 7, amino acids 51-58 of SEQ ID NO: 7, and amino acids 97-109 of SEQ ID NO: 7, wherein residue 56 is G and residue 109 is N; and wherein the light chain variable region comprises the amino acid sequence set forth as amino acids 27-32 of SEQ ID NO: 8, amino acids 50-52 of SEQ ID NO: 8 and amino acids 89-97 of SEQ ID NO: 8, wherein the human monoclonal antibody or antigen binding fragment specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (K