Patent ID: 6224848
Filing Date: 2001-05-01
Classification: A61K,A61N

Abstract:
A pharmaceutical composition comprising:a) a pharmaceutically acceptable solvent, excipient or diluent; andb) a Mossbauer absorber atom that is excitable with resonant radiation and that is attached to a chemical which binds to DNA, wherein said chemical which binds to DNA comprises at least one DNA binding, modified form of a compound selected from the group consisting of Phenosafranine, Triostin A, Mithramycin, Chromomycin A.sub.3, Phenoxazone Antibiotics, Acridine, Acridinylmethanesulphonanilide, Diacridine, Proflavine, Rhodanine, Acriflavine, 8-Aminoquinoline, Chloroquine, 2-Hydroxyethanethiolato-(2,2',2""-terpyridine)-platinum (II), Naphtholthiophene-ethanolamine, Phenathridine (Ethidium Bromide), Phenanothroline, Ellipticene, 2-Methyl-9-hydroxyellipticine, Tilorone, Thioxanthenone, Psoralen, Distamycin A, Netrospin, Hydroxystilbamide, Berenil, DAPI, Hoechst 33258, Irehydiamine A, Dipyradium, Letheoskyrin, Kanchanomycin, Pyrrolo-(1,4)-benzodiazepine Antibiotics, Sibiromycin, Ethylenimine (Triethylene Thiophosphoramide), N-2-Acethylaminofluorene, Benzopyrene, cis-Diamminedichloroplatinum (II), Hedamycin, Rubiflavin, Stretonigrin and Neocarzinostatin.