Patent ID: 7157425
Filing Date: 2007-01-02
Classification: A61K,A61P,C07K

Abstract:
1. An Apo A-I agonist compound comprising: (i) a 22 to 29-residue D-enantiomeric peptide or peptide analogue which forms an amphipathic α-helix in the presence of lipids and which comprises formula (I): or a pharmaceutically acceptable salt thereof, wherein: (C 5 –C 20 ) aryl, (C 6 –C 26 ) alkaryl, 5–20 membered heteroaryl, 6–26 membered alkheteroaryl or a 1 to 7-residue peptide or peptide analogue in which one or more bonds between residues 1 through 7 are independently a substituted amide, an isostere of an amide or an amide mimetic; and each “-” between residues X