Patent ID: 7160916
Filing Date: 2007-01-09
Classification: A61K,A61P

Abstract:
1. A method for increasing bone density, comprising administering to a subject in need thereof an amount of a compound effective for increasing bone density, wherein said compound is a compound of the formula: wherein, A is Ar 1 is phenyl, Ar 2 is 5′-furyl, Ar 3 is phenyl and n is 1; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH 2 , C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, ROC(O)R′OH, NHR, NRR′, RNHR′, or RNR′R″; or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are ORO; wherein each of R, R′, and R″, independently is C 1 ˜C 6 alkyl; and wherein said subject has osteoporosis, bone fracture, failed arthrodesis, dyschondroplasia, achondroplasia or congenital pseudoarthrosis.