Patent ID: 8367611
Filing Date: 2013-02-05
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method for inhibiting follicle-stimulating hormone (FSH) production in a subject desiring to delay or inhibit his or her germ cell maturation, the method comprising administering to the subject in need thereof an amount of an activin receptor type IIa-immunoglobulin Fc domain (ActRIIa-Fc) fusion protein effective to reduce FSH levels in the subject, wherein the ActRIIa-Fc fusion protein comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3, wherein the amount administered results in an ActRIIa-Fc serum concentration of at least 1000 ng/mL, and wherein the ActRIIa-Fc fusion protein binds to activin.