Patent ID: 6071938
Filing Date: 2000-06-06
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula: ##STR30## or a pharmaceutically acceptable salt thereof, wherein X is O, S or NH;R and R.sup.1 are each independently selected from H and C.sub.1 -C.sub.4 alkyl or taken together represent C.sub.2 -C.sub.6 alkylene;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;R.sup.3 is(a) a 6-membered heterocyclic ring containing 1 N-hetero atom, said ring being linked to X by a ring carbon atom, optionally benzo-fused and optionally substituted, including in the benzo-fused portion, C.sub.1 -C.sub.6 alkyl, hydroxy, --OR.sup.5, halo, --S(O).sub.m R.sup.5, oxo, amino, --NHR.sup.5, --N(R.sup.5).sub.2, cyano, --CO.sub.2 R.sup.5, --CONH.sub.2, --CONHR.sup.5 or --CON(R.sup.5).sub.2, with the proviso that R.sup.3 is not an N-(C.sub.1 -C.sub.6 alkyl)pyridonyl group;(b), when X is NH, a group of the formula: ##STR31## (c), when X is NH, a group of the formula: ##STR32## R.sup.4 is phenyl substituted by a hydroxy group and optionally further substituted by 1 or 2 substitutents each independently selected from hydroxy, C.sub.1 -C.sub.6 alkyl, --OR.sup.5, halo, cyano and nitro;R.sup.5 is C.sub.1 -C.sub.6 alkyl;R.sup.6 is --OR.sup.5, --NHR.sup.5, --N(R.sup.5).sub.2, --SR.sup.5 or --NHR.sup.9 ;R.sup.7 is cyano;R.sup.8 is --OR.sup.5, --NHR.sup.5, --N(R.sup.5).sub.2, or --NHR.sup.9 ;R.sup.9 is phenyl optionally substituted by C.sub.1 -C.sub.6 alkyl, hydroxy, --OR.sup.5, halo, cyano or nitro; andm is 0, 1 or 2.