Patent ID: 6764682
Filing Date: 2004-07-20
Classification: A61K,A61P,C07H,C12N

Abstract:
An adjuvant composition for modulating an immune response to an antigen administered to a host, the composition consisting essentially of:(a) a mineral salt adjuvant which is selected from the group consisting of aluminum hydroxide, aluminum phosphate, calcium phosphate, zinc hydroxide and calcium hydroxide; in admixture with (b) at least one other adjuvant selected from the group consisting of (A) a glycosylamide which is a glycosylamide having the formula: â€ƒin which R1 denotes hydrogen or saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms; X represents â€”CH2â€”, â€”Oâ€” or â€”NHâ€”, R2 denotes hydrogen or saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms; R3, R4, and R5, independently of one another, denotes hydrogen, or SO42âˆ’, or PO42âˆ’, or other negatively charged moiety, or â€”COâ€”R6, R6 being an alkyl radical having up to 10 carbon atoms; R7 is L-alanyl, L-alpha-amino butyryl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutamyl, L-glycyl, L-histidyl, L-hydroxypropyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-omithinyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, and L-valyl or their D-isomers; and pharmaceutically acceptable salts of said gycosylamide, (B) an octadecyl ester of an aromatic amino acid and (C) a lipopeptide which is tripalmityl-S-glyceryl-cysteinylserylserine or N-palmityl-S-[2,3-(bis(palmityloxy))-2-(RS)propyl-[R]-cysteine.