Patent ID: 8309129
Filing Date: 2012-11-13
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising nanoparticles, said nanoparticles comprising: (a) a poorly water soluble drug having a solubility in water of less than 5 mg/mL over the pH range of 6.5 to 7.5 at 25° C., at least 90 wt % of said drug in said nanoparticles being non-crystalline; (b) ethylcellulose; and (c) a bile salt; wherein (i) said nanoparticles have an average size of less than 500 nm; (ii) said drug constitutes from 0.1 wt % to 75 wt %, said ethylcellulose constitutes from 2 wt % to 85 wt %, and said bile salt constitutes from 0.5 wt % to 60 wt % of the total mass of said drug, said ethylcellulose, and said bile salt in said nanoparticles; and (iii) said drug, said ethylcellulose, and said bile salt collectively constitute at least 80 wt % of said nanoparticles.