Patent ID: 6020361
Filing Date: 2000-02-01
Classification: A61K,C07D

Abstract:
A method of treating diabetes and/or hyperglycemia in a mammal having diabetes or hyperglycemia which comprises administering to said mammal a therapeutically effective amount of a compound having the formula: ##STR12## wherein R.sup.1 and R.sup.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;R.sup.2 is hydrogen;R.sup.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl;R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.7 and R.sup.8 are independently OR.sup.9 or NR.sup.10 R.sup.11 ;R.sup.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.3 to C.sub.12 cycloalkyl, phenyl, naphthyl, phenyl, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, C.sub.1 to C.sub.6 alkyl, thiophenyl, furanyl, --CHR.sup.12 COOR.sup.13, --CHR.sup.12 C(O)R.sup.13, --CHR.sup.12 CONR.sup.10 R.sup.11, --CHR.sup.12 OCOOR.sup.13, or --CHR.sup.12 OC(O)R.sup.13 ;R.sup.10 and R.sup.11 are independently hydrogen, C.sub.1 to C.sub.12 alkyl, phenyl, naphthyl, phenyl-C.sub.1 to C.sub.6 alkyl, furanylalkyl, or alkoxycarbonylalkyl;R.sup.12 and R.sup.13 are independently hydrogen, C.sub.1 to C.sub.12 alkyl, phenyl, naphthyl, or phenyl-C.sub.1 to C.sub.6 alkyl; and the pharmaceutically acceptable salts thereof, an enantiomer or diastereomer thereof, or a pharmaceutically acceptable salt thereof.