Patent ID: 7442370
Filing Date: 2008-10-28
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polypeptide comprising an amino acid sequence at least 90% identical to amino acids 8-113 of SEQ ID NO:1, wherein the polypeptide includes at least one amino acid substitution selected from the group consisting of: (a) an amino acid other than arginine at the position corresponding to position 14 in SEQ ID NO:1; (b) an amino acid other than arginine at the position corresponding to position 39 in SEQ ID NO:1; (c) an amino acid other than arginine at the position corresponding to position 68 in SEQ ID NO:1; and (d) an amino acid other than asparagine at the position corresponding to position 95 in SEQ ID NO:1, wherein the polypeptide, when dimerized, binds to GFRα3.