Patent ID: 7241766
Filing Date: 2007-07-10
Classification: A61P,C07D

Abstract:
1. A method of effecting in a subject at least one member selected from the group consisting of promoting hydration of mucosal surfaces, promoting ocular hydration, promoting corneal hydration, promoting mucus clearance in mucosal surfaces, treating ventilator-induced pneumonia, inducing sputum for diagnostic purposes, blocking sodium channels, treating chronic bronchitis, treating cystic fibrosis, treating sinusitis, treating vaginal dryness, treating dry eye, treating Sjogren's disease, treating distal intestinal obstruction syndrome, treating dry skin, treating esophagitis, treating dry mouth (xerostomia), treating nasal dehydration, treating chronic obstructive pulmonary disease, treating emphysema, treating pneumonia, treating constipation, treating chronic diverticulitis, treating rhinosinusitis, treating asthma, treating primary ciliary dyskinesia, and treating otitis media, comprising: administering to the subject an effective amount of a compound represented by formula (I): wherein X is hydrogen, halogen, trifluoromethyl, lower alkyl, unsubstituted or substituted phenyl, lower alkyl-thio, phenyl-lower alkyl-thio, lower alkyl-sulfonyl, or phenyl-lower alkyl-sulfonyl; Y is hydrogen, hydroxyl, mercapto, lower alkoxy, lower alkyl-thio, halogen, lower alkyl, unsubstituted or substituted mononuclear aryl, or —N(R R each R R wherein each R each x is, independently, O, NR each o is, independently, an integer from 0 to 10; each p is, independently, an integer from 0 to 10; with the proviso that (a) the sum of o and p in each contiguous chain is from 1 to 10 when x is O, NR each R wherein when two R each R each R each R each R each Z is, independently, CHOH, C(═O), CHNR each R each g is, independently, an integer from 1 to 6; each m is, independently, an integer from 1 to 7; each n is, independently, an integer from 0 to 7; each Q is, independently, C—R inclusive of all enantiomers, diastereomers, and racemic mixtures thereof.