Patent ID: 9175906
Filing Date: 2015-11-03
Classification: A61K,F26B

Abstract:
1. A method for enhancing the dissolution rate of drug particles comprising: (a) cooling a cold solid surface to less than 5° C.; (b) selecting a freezable organic solvent with a freezing point close to the temperature of the cold surface and into which a poorly water soluble drug substance dissolves; (c) dissolving the poorly water soluble drug substance in the freezable organic solvent into a solution; (d) contacting the solution with the cold solid surface so as to freeze the solution, wherein the rate of freezing of the solution is determined by the difference between the freezing point of the freezable organic solvent and the temperature to which the cold solid surface is cooled in step (a); and (e) removing the organic solvent, wherein the resulting particles have a mean volume average particle size from less than 0.05 microns to 24 microns, a surface area of at least 2 m