Patent ID: 8263798
Filing Date: 2012-09-11
Classification: B01J,C07B,C07C,C07D

Abstract:
1. A method for producing an optically active α-amino acid, comprising: alkylating a compound represented by Formula (IV): with a compound of Formula (V): to give a compound represented by Formula (VI): using a compound represented by Formula (I) that is pure with respect to its axial asymmetry as a phase-transfer catalyst: in a medium in the presence of an inorganic base, hydrolyzing an imino group (R under acidic conditions, and hydrolyzing an ester group (—CO wherein in Formula (I), R a hydrogen atom; or an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R a C R (i) a hydrogen atom; (ii) a halogen atom; (iii) a C (iv) a C (v) a C (vi) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (vii) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R R X in Formulae (IV) and (VI), R (i) a hydrogen atom; or (ii) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: with the proviso that a case where R R (i) a hydrogen atom; (ii) a C (iii) a C (iv) a C (v) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (vi) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R in Formulae (V) and (VI), R (i) a C (ii) a C (iii) a C (iv) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (v) a C in Formula (V), W is a functional group having a leaving ability, and in Formula (VI), * indicates a newly produced asymmetric center.