Patent ID: 8034764
Filing Date: 2011-10-11
Classification: A61K,A61P

Abstract:
1. A method of avoiding the induction of mRNA encoding suppressor of cytokine signaling (SOCS) 1 (SEQ ID NO: 1) polypeptide in a human cell exposed to a therapeutically effective amount of gamma interferon capable of inducing the SOCS 1 mRNA, the method comprising the steps of: (a) exposing the human cell to a series of gamma interferon dilutions to generate dose response data so as to identify the minimal amount of gamma interferon that will induce mRNA encoding SOCS 1 in the human cell; and (b) exposing the human cell to an therapeutically effective amount of a SOCS 1 inducing gamma interferon that is less than the minimal amount identified in step (a) so that the induction of mRNA encoding SOCS 1 in the human cell is avoided.