Patent ID: 7556969
Filing Date: 2009-07-07
Classification: G01N,Y10T

Abstract:
1. A method for detecting an analyte, said method comprising the steps of: covalently labeling an analyte, to produce a tag-analyte molecule, with a molecular tag of the form: causing said tag-analyte molecule to become a parent tag-analyte ion (XxyYZ-A ion) in the first stage of a tandem mass spectrometer; and causing said parent tag-analyte ion to fragment through cleavage from energetic activation to become a resonance stabilized daughter tag-analyte ion (yYZ-A ion) in the second stage of a tandem mass spectrometer, wherein said daughter tag-analyte ion forms from loss of a neutral fragment (Xx) from said parent tag-analyte ion, wherein said neutral fragment comes from the tag portion of said parent tag-analyte ion and wherein said resonance stabilized daughter ion yYZ-A is predominant relative to any other ion detected from said tag-analyte.