Patent ID: 9067908
Filing Date: 2015-06-30
Classification: A61K,A61P,A61Q,C07C,C07D

Abstract:
1. A topically applicable formulation useful for the preparation of a therapeutic, dermatological or cosmetic composition, comprising a bioprecursor having the structural formula: in which: PP is a polyphenol radical having the following formula: in which: or having the following formula: in which: A is a substituted or unsubstituted, saturated or unsaturated alkyl radical having from 1 to 20 carbon atoms, which is bonded to the polyphenol by: a carboxylic ester function on a hydroxyl function of the said polyphenol; or by means of an A′ spacer, in which A is bonded to A′ via a carboxylic ester function, and A′ is bonded to the polyphenol via a carboxylic ester function on a hydroxyl function of the said polyphenol; B is a precursor of a biologically active molecule which is bonded to the polyphenol by: a carboxylic ester function on a hydroxyl function of the said polyphenol; or by means of a B′ spacer, in which B is bonded to B′ via a carboxylic ester function, and B′ is bonded to the polyphenol by a carboxylic ester function on a hydroxyl function of the said polyphenol; and wherein the biologically active molecule is selected from the group consisting of lipoic acid, vitamins A, B, D, E, retinoic acids, and hydroxyacids; and wherein the groups A′ and B′ of the bioprecursor are, independently of one another, an aliphatic hydrocarbon chain comprising two acid functions or one acid function and one hydroxyl function having from 2 to 13 carbon atoms.