Patent ID: 7348324
Filing Date: 2008-03-25
Classification: A61P,C07D

Abstract:
1. A compound of the formula: wherein R 1 and R 2 combine with each other together with A to form a piperidinyl group which may be substituted; A is N or N + —R 5 ·Y − wherein R 5 is a hydrocarbon group and Y − is a counter anion; R 3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R 4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted; E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G 1 is a bond, CO or SO 2 ; G 2 is CO, SO 2 , NHCO, CONH or OCO; -Q-J-R- combine with the nitrogen to which they are attached to form a piperidinyl group, or a salt thereof, provided that the compound is not N-(3-{4-[4-(Aminocarbonyl)benzyl]-1-piperidinyl}propyl)-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide or a salt thereof, 1-Acetyl-N-(3-{4-[4-(aminocarbonyl)benzyl]-1-piperidinyl}propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinecarboxamide or a salt thereof, and N-(3-{4-[4-(Aminocarbonyl)benzyl]-1-piperidinyl}propyl)-N-(3-chloro-4-methylphenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide or a salt thereof.