Patent ID: 8597718
Filing Date: 2013-12-03
Classification: A61L,C23C,Y10T

Abstract:
1. A method for producing ultrathin film of 200 nm or less thickness of calcium phosphate crystals on a solid substrate comprising: (1) contacting the substrate with a first calcium phosphate ion solution having an ion concentration product of 1˜25 mM (2) contacting the substrate on which is formed the granules of amorphous calcium phosphate obtained in step (1) with a second calcium phosphate ion solution so as to form amorphous dendritic extensions from said granules of amorphous calcium phosphate on the substrate; (3) contacting the substrate on which is formed the granules of amorphous calcium phosphate and the amorphous dendritic extensions from the granules of amorphous calcium phosphate obtained in step (2) with a third calcium phosphate ion solution so as to remove the granules of amorphous calcium phosphate and leave behind the amorphous dendritic extensions from the granules of amorphous calcium phosphate; and (4) contacting the substrate on which remains the amorphous dendritic extensions from the granules of amorphous calcium phosphate obtained in step (3) with a fourth calcium phosphate ion solution so as to crystallize the amorphous dendritic extensions into calcium phosphate crystals and multiply the calcium phosphate crystals to coat the substrate with the calcium phosphate crystals.