Patent ID: 6582724
Filing Date: 2003-06-24
Classification: A61K,Y10S

Abstract:
A permeation enhancer topical or transdermal composition having a pH in the range of approximately 8.0 to approximately 13.0 and comprised of a hydroxide-releasing agent and a lipophilic co-enhancer having a molecular weight in the range of about 150 to 1000, an aqueous solubility of less than about 1 wt. %, and the structure (CH3â€”Lâ€”X)nR, wherein:n is 1 or 2; L is alkylene or alkenylene containing 1 to 3 double bonds, and from about 6 to about 22 carbon atoms; X is selected from the group consisting of â€”COOâ€”, â€”CH2Oâ€”, and â€”CH2Oâ€”(CO)â€”; and R is selected from the group consisting of H, lower alkyl, and lower alkyl substituted with one or two hydroxyl groups, with the proviso that if R is H, X is necessarily â€”CH2Oâ€”, and wherein when n is 2, R contains at least two carbon atoms; wherein the amount of hydroxide-releasing agent in the composition is the total of (a) the amount required to neutralize any acidic species in the composition plus (b) an amount equal to approximately 0.5 wt. % to 25 wt. % of the composition.