Patent ID: 6211195
Filing Date: 2001-04-03
Classification: A61P,C07D

Abstract:
A compound of formula ##STR10##including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, whereinX is S or SO.sub.2 ;R.sup.1 is C.sub.1-6 alkyl; NR.sup.5 R.sup.6, OR.sup.6 or SR.sup.6 ;R.sup.2 is C.sub.1-6 alkyl, C.sub.1-6 alkyloxy or C.sub.1-6 alkylthio;R.sup.3 is Ar.sup.1 or Het.sup.1 ;R.sup.4 is hydrogen or C.sub.1-6 alkyl;R.sup.5 is hydrogen, C.sub.1-8 alkyl, mono- or di(C.sub.3-6 cycloalkyl)methyl, C.sub.3-6 cycloalkyl, C.sub.3-6 alkenyl, hydroxyC.sub.1-6 alkyl, C.sub.1-6 alkylcarbonyloxyC.sub.1-6 alkyl or C.sub.1-6 alkyloxyC.sub.1-6 alkyl;R.sup.6 is C.sub.1-8 alkyl, mono- or di(C.sub.3-6 cycloalkyl)methyl, Ar.sup.2 CH.sub.2, C.sub.1-6 alkyloxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.3-6 alkenyl, thienylmethyl, furanylmethyl, C.sub.1-6 alkylthioC.sub.1-6 alkyl, mono- or di(C.sub.1-6 alkyl)aminoC.sub.1-6 alkyl, di(C.sub.1-6 alkyl)amino, C.sub.1-6 alkylcarbonylC.sub.1-6 alkyl;or R.sup.5 and R.sup.6 taken together with the nitrogen atom to which they are attached may form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C.sub.1-6 alkyl or C.sub.1-6 alkyloxyC.sub.1-6 alkyl; andAr.sup.1 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C.sub.1-6 alkyl, trifluoromethyl, hydroxy, cyano, C.sub.1-6 alkyloxy, benzyloxy, C.sub.1-6 alkylthio, nitro, amino and mono- or di(C.sub.1-6 alkyl)amino;Het.sup.1 is pyridinyl; pyridinyl substituted with 1, 2 or 3 substituents each independently selected from halo, C.sub.1-6 alkyl, trifluoromethyl, hydroxy, cyano, C.sub.1-6 alkyloxy, benzyloxy, C.sub.1-6 alkylthio, nitro, amino, and mono- or di(C.sub.1-6 alkyl)amino; andAr.sup.2 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, di(C.sub.1-6 alkyl)aminoC.sub.1-6 alkyl, or trifluoromethyl.