Patent ID: 7244706
Filing Date: 2007-07-17
Classification: A61K,A61P,C07K

Abstract:
1. A therapeutic method for treating a disease resulting from a microbial infection of an individual comprising: a) providing an antimicrobial polypeptide wherein the polypeptide is not SEQ ID NO:1, consisting of from N-terminus to C-terminus: b) administering a therapeutic amount of the antimicrobial polypeptide or functional variant thereof to the individual, wherein the functional variant is a substitute of a sequence shown in SEQ ID NO:2 having a basic residue at positions 2, 3, 4, 5, 28, 29, 31, 39 and 40, a hydrophobic residue at positions 7, 9, 10, 11, 12, 17, 18, 20, 21, 23, 32, 35, 37, 38, 44, 46, 47, 49 and 50, and an acidic residue at positions 16 and 41.