Patent ID: 7858773
Filing Date: 2010-12-28
Classification: A61P,C07D,C07H

Abstract:
1. A process for preparing compounds of formula X: wherein: R is selected from the group consisting of halo, hydroxy, azido, C R R R wherein: R R and wherein R and pharmaceutically acceptable salts thereof; the process comprising the steps of: (a) cyclizing a phenylenediamine of formula XI: with carbonyl di-imidazole to yield a compound of formula XII: (b) reacting the compound of formula XII with PO(X) (c) reacting the compound of formula XIII with a 5- or 6-membered, D- or L- sugar selected from the group consisting of: (d) optionally converting the compound of formula X or pharmaceutically acceptable derivative or prodrug thereof into a further compound of formula X or pharmaceutically acceptable derivative or prodrug thereof by nucleophilic substitution.