Patent ID: 8974789
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method of inhibiting the specific interaction between the outer membrane protein A (OmpA) of an adherent-invasive E. coli and the Gp96 endoplasmic reticulum localized stress response chaperone polypeptide expressed on ileal epithelial cells in patients having Crohn's disease or at risk of developing Crohn's disease, comprising administering to a patient having the Gp96 endoplasmic reticulum localized stress response chaperone polypeptide expressed on ileal epithelial cells, an anti-Gp96 antibody with a pharmaceutically acceptable carrier in an amount effective to inhibit the specific interaction between the Gp96 endoplasmic reticulum localized stress response chaperone polypeptide expressed on the ileal epithelial cells and the OmpA of the adherent-invasive E. coli.