Patent ID: 6492402
Filing Date: 2002-12-10
Classification: A61K,A61P,C07K

Abstract:
A compound having formula I: and pharmaceutically acceptable salts thereof wherein n is 2 A is hydrogen, alkyl, C3-7 cycloalkyl, aryl, â€”SO2R1, â€”SO3R1, â€”COR1, â€”CO2R2, â€”PO(OR1)2,â€”(CH2)mCO2R1, â€”(CH2)mSO2R1, â€”(CH2)mSO3R1, or â€”(CH2)mPO(OR1)2, wherein R1 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, aryl, â€”(CH2)maryl, or â€”NR3R4, and R2 is C1-6 alkyl, C3-7 cycloalkyl, aryl, â€”(CH2)maryl, or alkenyl, m is 1, 2, or 3, wherein aryl is unsubsituted or substituted phenyl or 5-6 membered aromatic heterocyclic ring, R3 and R4 are independently hydrogen, C1-6 alkyl, or C3-7 cycloalkyl, and B is hydrogen or C1-6 alkyl, and C and D are independently hydrogen, phenyl unsubsituted or substituted with one or two substituents selected from C1-4 alkyl, C1-4 alkoxy, CF3, methylenedioxy, halogen, hydroxy, or â€”NR3R4, a 5-6 membered heterocyclic ring system which may be saturated or unsaturated, and which consists of carbon atoms and 1-3 heteroatoms selected from the group consisting of N, O, and S, or C and D are C4-7 cycloalkyl; and E is â€ƒwherein X is S, O, or NR5, Y and Z are independently N or CR6, wherein R5 is hydrogen or C1-4 alkyl and R6 is hydrogen, halogen, CF3 or C1-4 alkyl, and F is â€”C(NH)N(R7)2, â€”C(NH2)NN(R7)2,â€”C(NH2)NOH, or -CH2NH(R7)2 wherein R7 is the same or different, R7 is hydrogen, C1-4 perfluoroalkyl or C1-4 alkyl.