Patent ID: 9128107
Filing Date: 2015-09-08
Classification: G01N

Abstract:
1. A method for prediction of the progression of primary chronic kidney disease or for monitoring chronic kidney disease therapy, comprising: a. detecting and quantitating the level of one or more markers selected from the group consisting of MR-proADM of SEQ ID NO:4 and/or MR-proANP of SEQ ID NO:10 in a sample from a patient suffering from chronic kidney disease, wherein said detection and quantitation comprises contact the sample with a diagnostic assay reagent comprising a capture probe that specifically binds to MR-proADM or MR-proANP, respectively, and detecting and quantitating thus-formed complexes of capture probe and MR-proADM and/or MR-proANP, b. predicting the progression of primary chronic kidney disease or monitoring chronic kidney disease therapy by comparing the level of MR-proADM and/or MR-proANP in the patient to a predetermined statistically significant cutoff level of MR-proADM and/or MR-proANP in an ensemble of pre-determined samples in a population of primary chronic kidney disease patients whose chronic kidney disease progressed (progressor) or did not progress (non-progressor), with or without said therapy, wherein said prediction is based on a statistically significant correlation of the level of MR-proADM and/or MR-proANP with the levels of the marker in the pre-determined samples.