Patent ID: 8883197
Filing Date: 2014-11-11
Classification: A61K

Abstract:
1. A transdermal therapeutic system (TTS), comprising a first compartment and a second compartment, wherein said first compartment comprises a detachable, outer backing layer and a pressure-sensitive adhesive polymer matrix containing an active substance in a solid state of aggregation, wherein one side of said pressure-sensitive adhesive polymer matrix fixes said transdermal therapeutic system on the skin, and comprises an active substance-impermeable, detachable protective layer for covering the side of said pressure-sensitive adhesive polymer matrix for fixing said transdermal therapeutic system on the skin; and wherein said second compartment is an enhancer compartment comprising a liquid zreservoir system containing at least one skin permeation enhancer in liquid form, wherein said active substance is at least partially soluble in said at least one skin permeation enhancer; and wherein said first compartment and said second compartment, in the condition of manufacture, are present separate from each other and are connectable with each other after removal of the detachable, outer backing layer from the first compartment for applying said first compartment and said second compartment in such a way that the side of the first, active substance-containing compartment which is opposite the side covered with the detachable protective layer is connected with the second, enhancer-containing compartment, wherein the second enhancer-containing compartment further comprises a control membrane for controlling diffusion of the at least one skin permeation enhancer into the active substance-containing compartment for forming an oversaturated system of the active substance; and wherein said transdermal therapeutic system further comprises an inner backing layer for separating said first compartment and the enhancer compartment, after having been combined with one another, wherein said inner backing layer is perforated or is a layer having high permeability to said at least one skin permeation enhancer.