Patent ID: 8367640
Filing Date: 2013-02-05
Classification: A61K,A61P

Abstract:
1. A complex consisting of (1) a polysaccharide substituted with a tryptophan salt and (2) a heparin-binding protein (HBP), wherein the polysaccharide is a dextran functionalized with at least the tryptophan salt: said tryptophan salt being grafted or bound to the polysaccharide via coupling with an acid function, said acid function borne by a linker R bound to the polysaccharide via a function F, said function F resulting from coupling between the linker R and an —OH function of the polysaccharide, Trp being a residue of the tryptophan salt, L- or D-isomer, produced by coupling between the amine of tryptophan and at least one acid borne by the group R, said HBP being selected from the group consisting of: