Patent ID: 8956387
Filing Date: 2015-02-17
Classification: A61B,A61F,A61M,A61N

Abstract:
1. A system for inducing physiological effects of ischemic conditioning and physiological effects of shear stress in a subject's body, the system comprising: (a) a first device configured to cause ischemia in a subject's body part; (b) a second device configured to mechanically generate arterial shear stress in a subject's body part; (c) a third device configured to monitor one or more of markers of ischemia or hemodynamic parameters such as tissue oxygenation and temperature; markers of metabolism including lactate, pH, oxygen, carbon dioxide, ATP, ADP, adenosine, cytochrome oxidase, redox voltage, erythropoietin, bradykinin, opioids; and markers of blood flow or pulse; or combinations thereof; (d) a microcontroller capable of automatically controlling a first actuator to induce ischemic condition, controlling a second actuator to control a second device to generate arterial shear stress, and controlling a third actuator to activate a third device concurrently monitoring one or more markers of ischemia or hemodynamic markers; and (e) a first actuator to cause the first device to cause ischemia in a subject's body part for a preset duration and then stop the ischemia for a preset duration, and to repeat the ischemia and reflow periods according to a preset program; a second actuator to simultaneously cause the second device to mechanically generate arterial shear stress according to a preset program of mechanical pulse amplitude, duration, and frequency; and a third actuator to activate the third device to concurrently monitor one or more markers of ischemia or hemodynamic parameters, wherein the microcontroller causes automatic execution of the preset programs.