Patent ID: 7696169
Filing Date: 2010-04-13
Classification: A61K,A61P,G01N,Y02A

Abstract:
1. A method for inhibiting the release of a proinflammatory cytokine from a cell, comprising administering to said cell an effective amount of a soluble toll-like receptor 2 (sTLR2), and measuring the inhibition of HMGB 1-mediated release of a proinflammatory cytokine from the cell, wherein said sTLR2 comprises: an amino acid sequence that has at least 95% sequence identity to amino acids 1-587 of SEQ ID NO: 46; that binds to a high mobility group box 1 (HMGB 1) polypeptide; and that inhibits HMGB 1-mediated release of a proinflammatory cytokine from a cell.