Patent ID: 8420799
Filing Date: 2013-04-16
Classification: A01K,A61K,A61P,C07H,C07K,C12N

Abstract:
1. An iRNA duplex agent comprising a first and a second sequence, having a first monomer in the first sequence and a second monomer in the second sequence within the first 3, 4, 5, or 6 positions from either the 3′ end or the 5′ end, wherein the first and second monomers are selected such that i) the first and second monomers are naturally occurring ribonucleotides or modified ribonucleotides having naturally occurring bases, wherein the ribonucleotide of the first monomer and the ribonucleotide of the second monomers, when occupying complementary sites that do not pair and have no substantial level of H-bonding, form a non canonical Watson-Crick pairing; and ii) the stability of the pairing of the monomers contributing to forming a duplex between the first and second sequence differs from the stability of the pairing between the first sequence and a target sequence or between the second sequence and a target sequence, wherein the iRNA agent comprises a TT overhang sequence.