Patent ID: 6093820
Filing Date: 2000-07-25
Classification: A61P,C07D

Abstract:
A method of N-alkylating ureides comprising reacting a ureide of formula I ##STR25## with an ester of a sulfonic acid of formula III ##STR26## in the presence of a base in an aprotic reaction medium, to provide a corresponding alkylated ureide, wherein R.sub.1 and R.sub.2 are each either non-cyclic alkyl, aryl, arylalkyl, or R.sub.1 and R.sub.2 together form a cyclic group having a total of at least 5 atoms each of which is selected from the group consisting of carbon, nitrogen and oxygen, and wherein R.sub.3 =H, lower alkyl, phenyl, or alkyl substituted phenyl, R.sub.4 =H, lower alkyl, phenyl, or alkyl substituted phenyl, and R.sub.5 =lower alkyl, phenyl, or alkyl substituted phenyl.