Patent ID: 7943779
Filing Date: 2011-05-17
Classification: C07D

Abstract:
1. A process for the preparation of olmesartan medoxomil which comprises: (i) alkylating ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (III) with 4-[2-(trityltetrazol-5-yl)phenyl]-benzyl bromide (IVa) or 4′-bromomethylbiphenyl-2-carbonitrile (IVb) in acetonitrile and in the presence of a base to yield a reaction suspension; (ii) crystallizing and filtering the reaction suspension, wherein acetonitrile is also used as a crystallization solvent, to obtain an ethyl ester of formula (V); and (iii) converting the ethyl ester of formula (V) to olmesartan medoxomil in a one pot process comprising: