Patent ID: 8080236
Filing Date: 2011-12-20
Classification: A61K,A61P,B01J,Y10S,Y10T

Abstract:
1. An inhaler comprising: an aerosol formulation comprising a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm, suspended in a nonsolvent hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v, which formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the nonsolvent hydrofluorocarbon fluid vehicle, wherein the particulate active substance comprises dihydroergotamine, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof and the nonsolvent hydrofluorocarbon fluid vehicle comprises 1,1,1,2-tetrafluoroethane (HFA 134a) or 1,1,1,2,3,3,3-heptafluoropropane (HFA 227ea).