Patent ID: 9107904
Filing Date: 2015-08-18
Classification: A61K,A61P,Y02A

Abstract:
1. A vaccine adjuvant comprising a plurality of amphiphilic albumin-binding conjugates, wherein the conjugate comprises (a) a lipid component; (b) an optional polar component; and (c) an immunomodulatory compound or molecular adjuvant; wherein the immunomodulatory compound or molecular adjuvant is covalently linked to the lipid via a nucleotide or oligonucleotide linker comprising “n” guanines, wherein n is 1-10, wherein the conjugate is sufficiently soluble such that the lipid binds to albumin under physiological conditions, and wherein accumulation of the conjugate in the lymph node following administration to a subject in vivo is increased relative to administration of the immunomodulatory compound or molecular adjuvant alone.