Patent ID: 6492387
Filing Date: 2002-12-10
Classification: A61P,C07D

Abstract:
A compound of Formula (I) and Formula (II): whereinA is selected from the group consisting of aryl and heteroaryl optionally substituted with one to two substituents independently selected from the group consisting of C1-4alkyl, C1-4alkoxy, aryl, aryl(C1-4)alkyl, amino (optionally substituted with one or two substituents independently selected from C1-4alkyl), amino(C1-4)alkyl (wherein amino is optionally substituted with one or two substituents independently selected from C1-4alkyl), C1-4alkylthio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, halogen, tri(halo)C1-4alkyl, tri(halo)C1-4alkoxy, hydroxy, hydroxyC1-4alkyl, cyano and nitro; R1, R2 and R3 are independently selected from the group consisting of hydrogen and C1-4alkyl; R4 is independently selected from the group consisting of hydrogen, C1-4alkyl, C1-4alkoxy, aryl, aryl(C1-4)alkyl, amino (optionally substituted with one or two substituents independently selected from C1-4alkyl), amino(C1-4)alkyl (wherein amino is optionally substituted with one or two substituents independently selected from C1-4alkyl), halogen, tri(halo)C1-4alkyl, tri(halo)C1-4alkoxy, hydroxy, hydroxyC1-4alkyl, cyano and nitro; n is an integer from 1 to 5; and, m is an integer from 1 to 2; and pharmaceutically acceptable acid addition salts thereof;with the proviso that a compound selected from Formula (I) cannot be 2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-3-yl]-ethanone.