Patent ID: 6071722
Filing Date: 2000-06-06
Classification: A61K,A61P,C07K

Abstract:
An isolated polynucleotide comprising a polynucleotide sequence that has at least 95% identity to a nucleotide sequence which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein said polynucleotide sequence may include up to n.sub.n nucleotide alterations over the entire region coding for SEQ ID NO:2, wherein n.sub.n is the maximum number of nucleotide alterations and is calculated by the formulan.sub.n .ltoreq.x.sub.n -(x.sub.n .multidot.y),in which x.sub.n is the total number of nucleotides which encode the amino acid sequence of SEQ ID NO:2 and y has a value of 0.95, wherein any non-integer product of x.sub.n and y is rounded down to the nearest integer prior to subtracting such product from x.sub.n.