Patent ID: 7595303
Filing Date: 2009-09-29
Classification: A61K,A61P

Abstract:
1. A method for modulating an immune response, comprising co-administering to a mammal: an effective amount of a nucleic acid sequence encoding p35 and p40 subunits of human IL-12, and a promoter sequence operably linked to the nucleic acid sequence encoding the p35 and p40 subunits; an effective amount of a nucleic acid sequence encoding human IFN-γ, and a promoter sequence operably linked to the nucleic acid sequence encoding human IFN-γ; and an antigen, such that the co-administering results in an increase of IFN-γ and IL-2 production, an increase of IgG2a specific to the antigen, a decrease of IL-4 production, and reduced serum IgE.