Patent ID: 9169316
Filing Date: 2015-10-27
Classification: A61P,C07K

Abstract:
1. An isolated chimeric antibody comprising all of the VHH or humanized VHH domains, fused to constant regions of human antibodies wherein said antibody is a chimeric antibody that does not contain a light chain variable domain, and wherein the antibody has a Fab type format and comprises two different VHH domains, or two human VH domains on which are grafted the VHH CDRs, wherein one of the domains is fused to the Cκ or Cλ constant region of a human immunoglobulin, the other domain is fused to the CH1 region of an immunoglobulin, wherein said chimeric antibody recognizes CD16 or CEA and wherein said antibody comprises an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of, respectively, sequences SEQ ID NO:81,SEQ ID NO:82,SEQ ID NO:83,SEQ ID NO:84,SEQ ID NO:106 and SEQ ID NO:107 or SEQ ID NO:85,SEQ ID NO:86,SEQ ID NO:87, SEQ ID NO:88 and SEQ ID NO:108.