Patent ID: 6331537
Filing Date: 2001-12-18
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula (I): ##STR79##wheren is 3;X is either O or S;R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, aryl, heteroaryl, carbocycle, or heterocycle;D is a bond, or a C.sub.1 -C.sub.10 straight or branched chain alkyl, C.sub.2 -C.sub.10 alkenyl or C.sub.2 -C.sub.10 alkynyl;R.sub.2 is selected from the group consisting of --COOH; --SO.sub.3 H; --SO.sub.2 HNR.sup.3 ; --PO.sub.2 (R.sup.3).sub.2 ; --CN; --PO.sub.3 (R.sup.3).sub.2 ; --OR.sup.3 ; --SR.sup.3 ; --NHCOR.sup.3 ; --N(R.sup.3).sub.2 ; --CONZ(R.sup.3); --CONH(O)R.sup.3 ; --CONHNHSO.sub.2 R.sup.3 ; --COHNSO.sub.2 R.sup.3 ; --CONR.sup.3 CN; ##STR80##wherein any of the atoms of said ring structure are optionally substituted in one or more positions with R.sup.3 ; andwherein said alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocycle, or heterocycle is optionally substituted with one or more substituents selected from R.sup.3 and Z, where R.sup.3 and Z are independently hydrogen, hydroxy, halo, haloalkyl, thiocarbonyl, alkoxy, alkenoxy, alkylaryloxy, aryloxy, arylalkyloxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, alkylthio, sulfonyl, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl or alkynyl, aryl, aralkyl, heteroaryl, carbocycle, heterocycle, or CO.sub.2 R.sup.7 where R.sup.7 is hydrogen or C.sub.1 -C.sub.9 straight or branched chain alkyl or C.sub.2 -C.sub.9 straight or branched chain alkenyl;or a pharmaceutically acceptable salt, ester, or solvate thereof.