Patent ID: 6794377
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
A compound of formula I, in which:A1, A2, A3, A4, A5, A6, A7 and A8 independently of one another are chosen from nitrogen and CH, one of these groups being nitrogen; R(1) is C(O)OR(9); wherein R(9), is CxH2xâ€”R(14); where x is 0, 1, 2, 3 or 4, and x cannot be 0 if R(14) is OR(15) or SO2Me; R(14) is alkyl having 1, 2, 3, 4, 5 or 8 atoms, cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms, CF3, C2F5, C3F7, CH2F, CHF2, OR(15), SO2Me, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted furyl, substituted or unsubstituted thienyl or a substituted or unsubstituted N-containing heteroaromatic having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, where the substituted phenyl, substituted naphthyl, substituted biphenylyl, substituted furyl, substituted thienyl and the substituted N-containing heteroaromatic are each independently substituted by 1, 2 or 3 substituents chosen from F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R(15) is alkyl having 1, 2, 3, 4 or 5 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, CF3 substituted phenyl or unsubstituted phenyl, wherein the substituted phenyl is substituted by 1, 2 or 3 substituents chosen from F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; and R(13) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or CF3; R(2) is hydrogen; R(3) is CyH2yâ€”R(16); where y is; R(16) is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, or cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms, R(30) and R(31) are hydrogen; or R(30) and R(31) together are oxygen; or a pharmaceutically tolerable salt thereof, in any stereoisomeric form, or a mixture of any such compounds in any ratio.