Patent ID: 8592393
Filing Date: 2013-11-26
Classification: A61K,A61P,C08B

Abstract:
1. A pharmaceutical composition comprising a polysaccharide preparation having the following characteristics: (a) a weight average chain molecular weight between 3,500 and 8,000 Da; (b) anti-Xa activity of less than 20 IU/mg and anti-IIa activity of 1 IU/mg or less; (c) greater than 5% and less than 25% glycol split uronic acid residues; (d) the polysaccharide preparation has a molecular weight distribution such that 10-40% of the oligosaccharides of the preparation have a molecular weight <3000 Da; 45-65% of the oligosaccharides have a molecular weight between 3000-8000 Da, and 15-30% of the oligosaccharides have a molecular weight >8000 Da; and (e) the preparation comprises polysaccharides that comprise Formula I: wherein each occurrence of U indicates a uronic acid residue and each occurrence of H indicates a hexosamine residue; wherein m and n are integers such that m=4-16, and n=1-4; each of w, x, y and z can, independently, be the same or different for each occurrence of [U w=-2OS or -2OH; x=—NS or —NAc; y=-3OS or -3OH; z=-6OS or -6OH; wherein the symbol ˜ indicates that the units marked m and n are distributed along the polysaccharide chain and are not necessarily in sequence.