Patent ID: 8609332
Filing Date: 2013-12-17
Classification: C12N,G01N

Abstract:
1. A method of determining whether a tumour cell is likely to have an increased incidence of metastasis comprising the steps: determining the level of a marker in a tumour cell from a sample, wherein the marker is at least one member of the group comprising the RAN polypeptide of SEQ ID NO 1, the RAN Binding Protein 1 of SEQ ID NO 3, an active fragment of said RAN polypeptide, an active fragment of said RAN Binding Protein 1, a nucleic acid sequence encoding said RAN polypeptide, a nucleic acid sequence encoding said RAN Binding Protein 1, a nucleic acid sequence encoding an active fragment of said RAN polypeptide, and a nucleic acid sequence encoding an active fragment of said RAN Binding Protein 1 and comparing the level of the marker detected with the level determined for the marker in a non-invasive and/or non-metastatic tumour cell, wherein an increase in the level of the marker in the tumour cell from the sample is indicative that the tumour cell is likely to have an increased incidence of metastasis.