Patent ID: 6025517
Filing Date: 2000-02-15
Classification: C07C

Abstract:
A process for preparing fluoxetine comprising the steps of:(a) reducing benzoylacetonitrile to provide .alpha.-(2-aminoethyl)benzenemethanol;(b) reacting said .alpha.-(2-aminoethyl)benzenemethanol with an alkoxycarbonyl acylating agent to form an N-(3-hydroxy-3-phenylpropyl)urethane;(c) reacting said N-(3-hydroxy-3-phenylpropyl)urethane with a 4-(trifluoromethyl)phenyl synthon under arylalkyl ether-forming conditions to provide an N-[3-[4-(trifluoromethyl)phenoxy]-3-phenylpropyl)urethane; and(d) reducing said N-[3-[4-(trifluoromethyl)phenoxy]-3-phenylpropyl)urethane to provide N-methyl-3-phenyl-3-[(.alpha.,.alpha.,.alpha.-trifluoro-p-tolyl)oxy]propyl amine.