Patent ID: 8980952
Filing Date: 2015-03-17
Classification: A61K,A61P,B01J,B29L,B32B,C07K,G01N,Y10S

Abstract:
1. A method of ameliorating the effect of a reduction in blood flow in peri-infarct brain tissue in ischemic disease or injury in a subject comprising administering to a subject having a reduction in blood flow in peri-infarct brain tissue in ischemic disease or injury an amount of a compound that is effective to inhibit the activity of a NC Ca-ATP channel in a neuronal cell, a neuroglia cell, or a neural endothelial cell and that is effective to ameliorate the effect of a reduction in blood flow in peri-infarct brain tissue in ischemic disease or injury, wherein the compound is a sulfonylurea compound, a benzamido derivative, an imidazoline derivative, or a combination thereof, and wherein the effect of said reduction in said blood flow in peri-infarct brain tissue in said ischemic disease or said injury in the subject is ameliorated.