Patent ID: 6943191
Filing Date: 2005-09-13
Classification: A61P,C07C,C07F

Abstract:
1. A compound having an in vivo biological activity of 4 or greater as measured by an IP+SC score, the compound satisfying Formula 1 where both A and B are hydrogen, X is either hydrogen or halogen, Y is a single bond and R 1 is hydrogen, R 2 is selected from the group consisting of aliphatic groups having from about 3 to about 16 carbon atoms, aliphatic alcohols having from about 3 to about 16 carbon atoms, aliphatic amides having from about 3 to about 16 carbon atoms, aliphatic esters having from about 3 to about 16 carbon atoms, aliphatic ketones having from about 3 to about 16 carbon atoms, and aliphatic phosphonic acid esters, and R 3 is either ortho, meta or para with respect to R, and is selected from the group consisting of hydrogen, hydroxyl and halogen when at least one of A, B or X is other than hydrogen, and from the group consisting of hydrogen and halogen when A, B and X are hydrogen, or Formula 2 where A and B independently are selected from the group consisting of hydrogen and halogen, or both are carbon atoms in an aromatic ring, X is either hydrogen or halogen, Y is either a single bond or a double bond, R is either carbon or nitrogen, R 1 , is hydrogen or an aliphatic group having from about 1 to about 30 carbon atoms, R 2 is meta or para to R and is selected from the group consisting of amino, aliphatic amine, aliphatic alcohols, aliphatic amides, aliphatic esters, aliphatic ketones and phosphonic acid esters with the aliphatic groups comprising from about 1-30 carbon atoms, and R 3 is either ortho, meta or para to R and is selected from the group consisting of hydrogen, hydroxyl and halogen.