Patent ID: 8530476
Filing Date: 2013-09-10
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): wherein: Z is —N— or >CH; R Ar where each R Ar (a) unsubstituted 1-naphthyl; or a phenanthrenyl, pyrenyl, fluorenyl, 2-naphthyl, or N—R wherein each R (b) phenyl fused at two adjacent ring carbon atoms to a group selected from the group consisting of —(CH (c) Ar (d) a 9- or 10-membered fused bicyclic heteroaryl having one heteroatom selected from the group consisting of N, O, and S, with a carbon atom as point of ring attachment, and optionally having up to four additional carbon ring atoms replaced with nitrogen, said fused bicyclic heteroaryl having not more than five heteroatoms, and unsubstituted or substituted with one, two, or three R (e) phenyl substituted at the 3- or 4-position with R wherein each R each R (f) phenyl substituted at the 3- or 4-position with -L-Ar where each of the moieties (1) through (4) is optionally di-substituted on adjacent carbons with —OC wherein each R (g) 2-hydroxyphenyl or 2-methoxyphenyl, unsubstituted or substituted with one, two, or three substituents R wherein each R (h) 4-halophenyl, unsubstituted or substituted with one, two, or three substituents R wherein each R (i) 2-bromophenyl, 3-methylphenyl, 3-methoxyphenyl, 4-methoxyphenyl, or 3,4-dimethoxyphenyl; or a pharmaceutically acceptable salt of such compound.