Patent ID: 6703208
Filing Date: 2004-03-09
Classification: C12Q,G01N

Abstract:
A method for diagnosis of celiac disease in an individual comprising the steps of:(a) contacting transglutaminase with glutenin to form complexes of transglutaminase and glutenin; (b) contacting a sample of serum obtained from the individual with the complexes of transglutaminase and glutenin; and (c) detecting antibodies to the complexes of transglutaminase and glutenin in the sample from the individual, wherein the presence of the antibodies to the complexes of transglutaminase and glutenin is indicative of celiac disease and wherein the sensitivity of diagnosis of celiac disease is higher with detection of antibodies to the complexes of transglutaminase and glutenin than with detection of antibodies to transglutaminase alone or glutenin alone.