Patent ID: 6627628
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A compound of formula I, wherein R1 and R2, which are independent of one another and can be identical or different, are selected from the group consisting ofhydrogen, (C1-C8)-alkyl, wherein the (C1-C8)-alkyl is unsubstituted or substituted by at least one identical or different substituents chosen from hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl-S(O)mâ€”, phenyl, naphthyl and pyridyl, (C3-C9)-cycloalkyl, wherein the (C3-C9)-cycloalkyl is unsubstituted or substituted by at least one identical or different substituents chosen from (C1-C4)-alkyl, hydroxyl, amino and benzyl, and a radical of a 5-membered to 7-membered saturated heterocyclic ring which contains one or two identical or different hetero ring members chosen from O, NR10 and S(O)m, wherein the 5-membered to 7-membered saturated heterocyclic ring is unsubstituted or substituted by at least one identical or different substituents chosen from (C1-C4)-alkyl, hydroxyl and aryl-(C1-C4)-alkyl, wherein the radicals phenyl, naphthyl, pyridyl and benzyl contained in the radicals R1 or R2 are unsubstituted or substituted in the aromatic ring by at least one identical or different substituents chosen from halogen, (C1-C4)-alkyl, phenyl, CF3, NO2, OH, â€”Oâ€”(C1-C4)-alkyl, â€”Oâ€”(C2-C4)-alkyl-Oâ€”(C1-C4)-alkyl, (C1-C2)-alkylenedioxy, NH2, â€”NHâ€”(C1-C4)-alkyl, â€”N((C1-C4)-alkyl)2, â€”NHâ€”CHO, â€”NHâ€”COâ€”(C1-C4)-alkyl, â€”CN, â€”COâ€”NH2, â€”COâ€”NHâ€”(C1-C4)-alkyl, â€”COâ€”N((C1-C4)-alkyl)2, â€”COâ€”OH, â€”COâ€”Oâ€”(C1-C4)-alkyl, â€”CHO and â€”COâ€”(C1-C4)-alkyl, but where R1 and R2 cannot both simultaneously be hydrogen; or the radical R1R2N is a radical, bonded via a ring nitrogen atom, of a 5-membered to 7-membered saturated heterocyclic ring which, in addition to the nitrogen atom carrying the radicals R1 and R2, can contain at least one further hetero ring member chosen from O and S(O)m wherein the 5-membered to 7-membered saturated heterocyclic ring is unsubstituted or substituted by at least one identical or different substituents chosen from (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy and R11R12N; R3 is aryl but cannot be unsubstituted phenyl; R10 is hydrogen, (C1-C4)-alkyl, aryl-(C1-C4)-alkyl-, hydroxy-(C1-C4)-alkyl-, hydroxycarbonyl-(C1-C4)-alkyl-, ((C1-C4)-alkoxycarbonyl)-(C1-C4)-alkyl-, R11R12Nâ€”COâ€”(C1-C4)-alkyl-, R13â€”SO2â€” or aryl; R11 and R12 are identical or different radicals selected from the group consisting of hydrogen and (C1-C4)-alkyl; R13 is (C1-C4)-alkyl, aryl or R11 R12 N; wherein aryl is chosen from phenyl, naphthyl and heteroaryl, and wherein said phenyl, naphthyl, and heteroaryl is unsubstituted or substituted by at least one identical or different substituents chosen from halogen, (C1-C4)-alkyl, phenyl, CF3, NO2, OH, â€”Oâ€”(C1-C4)-alkyl, â€”Oâ€”(C2-C4)-alkyl-Oâ€”(C1-C4)-alkyl, (C1-C2)-alkylenedioxy, NH2, â€”NHâ€”(C1-C4)-alkyl, â€”N((C1-C4)-alkyl)2, â€”NHâ€”CHO, â€”NHâ€”COâ€”(C1-C4)-alkyl, â€”CN, â€”COâ€”NH2, â€”COâ€”NHâ€”(C1-C4)-alkyl, â€”COâ€”N((C1-C4)-alkyl)2, â€”COâ€”OH, â€”COâ€”Oâ€”(C1-C4)-alkyl, â€”CHO and â€”COâ€”(C1-C4)-alkyl; wherein heteroaryl is chosen from a radical of a monocyclic 5-membered aromatic heterocycle, a radical of a monocyclic 6-membered aromatic heterocycle, a radical of a bicyclic 8-membered aromatic heterocycle, a radical of a bicyclic 9-membered aromatic heterocycle, and a radical of a bicyclic 10-membered aromatic heterocycle, each of which contain at least one identical or different ring heteroatoms chosen from N, O and S; and m is 0, 1 or 2; or a salt thereof, in any stereoisomeric form, or a mixture of any such compounds in any ratio.