Patent ID: 6028208
Filing Date: 2000-02-22
Classification: A61P,C07C

Abstract:
A vitamin D.sub.3 derivative expressed by the following general formula (1) ##STR28## wherein, Z is 1a, 1b or 1c; R.sub.1 and R.sub.2 are identical to or different from each other, and are each a hydrogen atom, a tri(C.sub.1 -C.sub.7 alkyl)silyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R.sub.3 and R.sub.4 are identical to or different from each other, and are each a hydrogen atom, a hydroxyl group, a C.sub.2 -C.sub.8 acyloxy group, a C.sub.1 -C.sub.7 alkyloxy group, a C.sub.1 -C.sub.6 alkylthio group or a C.sub.1 -C.sub.7 alkyl group which is optionally substituted with a hydroxyl group, a C.sub.2 -C.sub.8 acyloxy group or a C.sub.1 -C.sub.7 alkyloxy group; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are identical to or different from each other, and are each a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.7 alkyl group or a C.sub.2 -C.sub.8 acyloxy group; R.sub.9 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.7 alkyl group or a C.sub.1 -C.sub.6 alkylthio group; R.sub.10 is a hydrogen atom, a C.sub.1 -C.sub.7 alkyl group or a C.sub.1 -C.sub.7 alkyloxy group; A and B are identical to or different from each other, and are each a hydrogen atom, a hydroxyl group, or together express a single bond and express a double bond in cooperation with the single bond already shown in the formula; X and Y together express (i) a carbonyl group in cooperation with the carbon atom to which they are bonded, (ii) one of them is a hydrogen atom and the other is a hydroxyl group, or (iii) one of them is a hydrogen atom and the other is a C.sub.2 -C.sub.8 acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2; or a pharmaceutically permissible solvate thereof.