Patent ID: 6641814
Filing Date: 2003-11-04
Classification: A61K,C07K

Abstract:
A substantially pure or isolated polypeptide whicha) consists of the amino acid sequence as shown in SEQ ID NO: 16, or b) consists essentially of the amino acid sequence shown in SEQ ID NO: 16 and is immunologically equivalent to the amino acid sequence shown in SEQ ID NO: 16 with respect to the ability of evoking a protective immune response in mice against infections with mycobacteria belonging to the tuberculosis complex or with respect to the ability of eliciting a diagnostically significant immune response indicating previous or ongoing sensitization with antigens derived from mycobacteria belonging to the tuberculosis complex, or c) consists essentially of an amino acid sequence with a sequence identity of at least 80% with SEQ ID NO: 16, and which is at least 6 contiguous amino acid residues of SEQ ID NO: 16, and is immunologically equivalent to the amino acid sequence shown in SEQ ID NO: 16 with respect to the ability of evoking a protective immune response in mice against infections with mycobacteria belonging to the tuberculosis complex or with respect to the ability of eliciting a diagnostically significant immune response indicating previous or ongoing sensitization with antigens derived from mycobacteria belonging to the tuberculosis complex; wherein â€œsequence identityâ€  is a measure of the degree of similarity between two amino acid sequences of equal length, calculated as (Nrefâˆ’Ndij)*100/Nref, wherein Ndif is the total number of non-identical residues in the two sequences when aligned and wherein Nref is the number of residues in one of the sequences.