Patent ID: 6727254
Filing Date: 2004-04-27
Classification: A61P,C07D

Abstract:
A compound represented by the formula or pharmaceutically acceptable salts thereof, whereinR is R4-heteroaryl or R1 is H or C1-C6 alkyl; R2 and R3 are independently selected from the group consisting of â€”CH3, â€”OCH3, fluoro, chloro, bromo and iodo; R4 is 1 to 4 substituents independently selected from the group consisting of H, halo, (C1-C6) alkyl, â€”CN, â€”CF3, â€”OCF3, â€”(CH2)nâ€”OR5, â€”(CH2)nâ€”NR5R6, â€”(CH2)nâ€”NHSO2 R5, â€”(CH2)nâ€”NH(CH2)2NR5R6, â€”(CH2)nâ€”NHC(O)NR5R7, â€”(CH2)nâ€”NH(CH2)2OR5 and 1-piperazinyl; n is 0, 1, 2 or 3; R5 and R6 are independently selected from the group consisting of H and C1-C-3 alkyl; and R7 is H, C1-C-3 alkyl or amino(C1-C-3)alkyl.