Patent ID: 6114381
Filing Date: 2000-09-05
Classification: A61K,C07C,C07D

Abstract:
A compound of Formula I: ##STR32## wherein each of R.sup.1, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.11 is independently selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, oxo, halo, haloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, aralkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, alkoxyalkyl, alkoxycarbonyl, aralkoxy, alkanoyl and amino and amido radicals of the formula ##STR33## wherein each of R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16 and R.sup.17 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, cycloalkylalkyl, alkoxyalkyl, aralkyl and aryl;wherein R.sup.3 is selected from hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, aryl, aralkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkenylalkyloxycarbonyloxy, alkoxycarbonyloxy, acyl and alkanoyl;wherein R.sup.9 is selected from alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, aryl, aralkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl and alkanoyl;wherein R.sup.10 is selected from hydrido, halo, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, alkoxyalkyl, and amino and amido radicals of the formula ##STR34## wherein each of R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16 and R.sup.17 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, cycloalkylalkyl, and alkoxyalkyl;wherein R.sup.10 and R.sup.11 may be taken together to form a fused aromatic ring; and wherein said fused aromatic ring may be substituted with one or more groups selected from alkyl, cycloalkyl, cycloalkylalkyl, carboxyl, oxo, halo, haloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, aralkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, alkoxyalkyl, alkoxycarbonyl, aralkoxy, aralkylthio, cyano, cyanoamino, alkanoyl, mercapto, alkylthio, arylthio, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, and amino radicals of the formula ##STR35## wherein each of R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22 and R.sup.23 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, cycloalkylalkyl, alkoxyalkyl, aralkyl and aryl;or a tautomer or an enantiomer thereof, or a pharmaceutically-acceptable ester or salt thereof.