Patent ID: 6511473
Filing Date: 2003-01-28
Classification: A61K,A61M,C12N

Abstract:
An implantable bioartificial active secretion system for providing a physiological regulating secretion necessary for functionality of a physiologic activity of a living-being host, the system comprising:a) a housing having an inlet with an external opening thereto and an outlet with an external opening therefrom, said housing implantable at least partially within the host such that the inlet and outlet openings are positionable in fluidic communication with tissue fluid of the host for receiving into and dispensing from the housing said tissue fluid; b) a chamber disposed within the housing between the inlet and outlet and in communication therewith, said chamber having therein a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological secretion; c) a periodically operating pump apparatus for drawing initial tissue fluid through the inlet from the host for contact with the physiologically active cells within the chamber for pick up of the physiological regulating secretion, and for dispensing resulting tissue fluid bearing said physiological secretion through the outlet and into the host; and d) an inlet filter in operational communication with the external opening of the inlet and disposed upstream of the chamber, said inlet filter having interstices therethrough sized for prohibiting passage into the chamber of immune system cells of the host.