Patent ID: 6693218
Filing Date: 2004-02-17
Classification: C07C

Abstract:
A process for the preparation of a compound of formula with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and <1% of a compound of formula (1b) (A2);and then subjecting the sertraline-imine isomeric mixture obtained according to reaction route (A1) or (A2), in a suitable solvent, to recrystallisation (B), in accordance with the following scheme: â€ƒwherein in formulae (1a), (1b), (2a) and (2b) R1, R2 and R3 are each independently of the others hydrogen, halogen, trifluoromethyl or C1-C4alkoxy.