Patent ID: 8388968
Filing Date: 2013-03-05
Classification: A61K,A61P,C07H,C07K

Abstract:
1. An anti-ActRIIB antibody or functional fragment comprising an antigen binding portion thereof, wherein the antibody or functional fragment binds to the ligand-binding domain of ActRIIB, and wherein the antibody comprises a heavy chain variable region CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 9 and 11; a heavy chain variable region CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 23 and 25; a heavy chain variable region CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 37 and 39; a light chain variable region CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 51 and 53; a light chain variable region CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 65 and 67; and a light chain variable region CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 79 and 81.