Patent ID: 7524852
Filing Date: 2009-04-28
Classification: A61P,C07D

Abstract:
1. A bicyclic pyrimidine represented by following Formula (I): {wherein m represents 1, n represents 2, R R A represents —C(═O)—, —SO 2 —, —NR 6D C(═O)— (wherein R 6D represents a hydrogen atom, substituted or unsubstituted lower alkyl or substituted or unsubstituted cycloalkyl, or is combined together with R 3 and the adjacent nitrogen atom to form a substituted or unsubstituted heterocyclic group), —NR 6D C(═S)—, —OC(═O)—, —OC(═S)—, —SC(═O)—, —SC(═S)—, and A is bonded to R 3 at the left side in the each group; and with the provisio that (a) when A is a single bond, then R 3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted heteroaromatic-substituted alkyl or substituted or unsubstituted heteroalicyclic-substituted alkyl, and (b) when A is —C(═O)—, —SO then R or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof.