Patent ID: 7999077
Filing Date: 2011-08-16
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated monoclonal antibody or an antigen-binding fragment thereof, wherein the antibody comprises A light chain with a L-CDR1, L-CDR2 and L-CDR3 region, and wherein L-CDR1 comprises the amino acid sequence set forth as amino acids 24 to 35 of SEQ ID NO:4, L-CDR2 comprises the amino acid sequence set forth as amino acids 51-57 of SEQ ID NO:4, and L-CDR3 comprises the amino acid sequence set forth as amino acids 90-98 of SEQ ID NO:4; and wherein the antibody comprises a heavy chain with a H-CDR1, H-CDR2 and H-CDR3 region, and wherein H-CDR1 comprises the amino acid sequence set forth as amino acids 31 to 35 of SEQ ID NO:3, H-CDR2 comprises the amino acid sequence set forth as amino acids 50 to 67 of SEQ ID NO:3, and H-CDR3 comprises the amino acid sequence set forth as amino acids 100-107 of SEQ ID NO:3, wherein the isolated monoclonal antibody specifically binds the amino acid sequence set forth as amino acids 287 to 565 of SEQ ID NO: 13.