Patent ID: 9072816
Filing Date: 2015-07-07
Classification: A61B,A61K,A61L,A61P

Abstract:
1. A composition for reducing inflammation of damaged cardiovascular tissue and inducing regeneration of cardiovascular tissue, comprising: an extracellular matrix (ECM) composition comprising acellular small intestine submucosa (SIS), and 0.1 μM of an added cerivastatin, said ECM composition further comprising transforming growth factor-β (TGF-β), wherein said cerivastatin is mixed with said ECM composition, wherein a statin-growth factor augmented ECM composition is formed, and wherein, when said statin-growth factor augmented ECM composition is administered to damaged cardiovascular tissue, said statin-growth factor augmented ECM composition inhibits localized expression of proinflammatory chemokine monocyte chemoattractant protein-1 (MCP-1) and proinflammatory receptor C—C chemokine receptor type-2 (CCR2), whereby, said statin-growth factor augmented ECM composition reduces inflammation of said damaged cardiovascular tissue and induces bioremodeling and regeneration of new cardiovascular tissue.