Patent ID: 6376480
Filing Date: 2002-04-23
Classification: A61P,C07C

Abstract:
A method of preparing a pharmaceutical composition, comprising combining a pharmaceutically compatible vehicle with a compound according to formula (I) whereinY1 is a hydrogen atom, a hydroxyl group, an alkanoyloxy group with 1 to 12C atoms or an aroyloxy group, Y2 is a hydrogen atom, an alkanoyl group with 1 to 12 C atoms or an aroyl group, R1 and R2 are each a hydrogen atom or together are an exocyclic methylene group, R3 and R4, are each independently of one another, a hydrogen atom, a chlorine atom, a fluorine atom, an alkyl group with 1 to 4 carbon atoms, or together form a methylene group or together with quaternary carbon atom 20 form a 3- to 7-membered, saturated or unsaturated carbocyclic ring, A and B together are a keto group, or A is ORâ€² and B is a hydrogen atom, or B is ORâ€² and A is a hydrogen atom, Râ€² is a hydrogen atom, a straight-chain or branched-chain, saturated alkanoyl group with up to 9 carbon atoms or an aroyl group, R5 and R6 at the same time are each a hydrogen atom, a chlorine atom, a fluorine atom, a trifluoromethyl group, or a straight-chain or branched-chain, saturated or unsaturated hydrocarbon radical with up to 4 carbon atoms or R5 and R6 together with carbon atom 25 are a 3- to 7-membered, saturated or unsaturated carbocyclic ring, and Z is a straight-chain or branched-chain, saturated or unsaturated hydrocarbon radical with up to 12 carbon atoms, which can also have a carbocyclic or heterocyclic structure or partial structure and at any positions can exhibit keto groups, hydroxy groups in &agr; or &bgr;-position which can be optionally etherified or esterified, amino groups, halogen atoms or carboxylic acid ester or amide units and is linked with carbon atom 25 by a carbonyl group, a hydroxymethylene group or an ethenediyl unit (E- or Z-geometry).