Patent ID: 8187874
Filing Date: 2012-05-29
Classification: A61K,C12Q,G01N

Abstract:
1. A method for identifying a compound having activity against a Hepatitis C Virus (HCV), comprising: (a) contacting compounds with a target in the HCV; (b) determining whether or not said compounds bind reversibly with the target, wherein the target is an HCV enzyme selected from the group consisting of a protease, a helicase, and a polymerase; (c) measuring the half-life of compounds bound to the target; and (d) selecting a compound having activity against HCV based on the reversible binding property and on the half-life of compounds bound to the target, wherein a compound that binds reversibly to the target and has a half-life bound to the target of at least about 25% of the half-life of the replication cycle of HCV is identified as a compound having activity against HCV.