Patent ID: 9125386
Filing Date: 2015-09-08
Classification: A01K,C07K,C12N

Abstract:
1. A genetically modified mouse, whose genome comprises a humanization of an endogenous mouse IL-6Rα gene at an endogenous mouse IL-6Rα locus, wherein the humanization comprises a replacement of a mouse IL-6Rα ectodomain-encoding nucleic acid with a human IL-6Rα ectodomain-encoding nucleic acid to form a humanized IL-6Rα gene, wherein the humanized IL-6Rα gene is under control of endogenous mouse regulatory elements at the endogenous mouse IL-6Rα locus, wherein the humanized IL-6Rα gene is expressed and encodes a humanized IL-6Rα protein which comprises said human IL-6Rα ectodomain and mouse IL-6Rα transmembrane and cytoplasmic domains, and wherein said genetically modified mouse does not express a fully mouse IL-6Rα and lacks an acute phase response to an acute phase inducer.