Patent ID: 7052700
Filing Date: 2006-05-30
Classification: A61K,A61P,G01N

Abstract:
1. A composition comprising Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Alba and Semen Persicae, wherein the composition is obtained by a method comprising steps of: a) obtaining, pruning, washing and cutting the plant parts: stem of b) drying the said plant parts to form 5 medicinal materials named, respectively: Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Alba and Semen Persicae; c) Smashing Ramulus Cinnamomi, Semen Persicae and Cortex Moutan into coarse powders and chopping Radix Paeoniae Alba into slices; d) Sterilizing the Poria before granulating 50% of its formula weight into fine powder and filtering the powder; e) putting the powder of Cortex Moutan through a process of hot reflux in water and collecting its distillate, saving both the residue and fluid; f) filtering and vacuum-drying said distillate to obtain crude Paeonol; g) dissolving the crude Paeonol into 95% alcohol to form solution A; Slowly adding solution A into a saturated water solution of β-cyclodextrin while agitating it at temperature of about 80° C. to form mixture A; h) filtering mixture A and washing the residue with anhydrous alcohol and letting the washed residue dry to obtain clathrate A; i) distilling Ramulus Cinnamomi in water for four hours and collecting its volatile matter, saving both residue and fluid; j) dissolving the volatile matter into 95% alcohol to form a solution B; slowly adding the solution B into saturated water solution of β-cyclodextrin while agitating it at temperature of about 45° C. to form a mixture B; k) filtering mixture B and washing the residue with anhydrous alcohol and letting the washed residue dry to obtain clathrate B; l) mixing residues frow step (e) and (i) with Radix Paeoniae Alba, Semen Persicae, 50% formula weight of Poria and 90% alcohol; extracting the mixture, filtering the extract and recovering alcohol from the filtered extract and saving the residue; m) adding water into the residue from step (l) distilling it and filtering the water extract; n) mixing the water extract from step (m), alcohol extract from step (l), fluid from step (e) and step (i); enriching the mixture to form a cream extract; o) mixing the cream extract from step (n) with Poria powder from step (d), grinding the mixture into a fine powder after vacuum-drying it to form a granule; p) mixing the fine powder with an appropriate amount of 60% alcohol and starch sum and granulating the powder to 30 meshes to form a granule A; q) mixing an appropriate amount of silicon dioxide with clathrate A from step (h) and clathrate B from step (k); and r) mixing the mixture from step (g) with granule A from step (p) to obtain a final granule B—the composition.