Patent ID: 6307052
Filing Date: 2001-10-23
Classification: C07D

Abstract:
A process for preparing a benzenesulfonic acid salt or a benzoic acid salt of the optically active piperidine compound represented by formula (I) ##STR13##which comprises reacting (.+-.)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]-piperidine with an optically active propionic acid compound represented by the formula (VII): ##STR14##wherein Y represents a hydrogen atom or a halogen atom; Z represents a lower alkoxy group; and * represents an asymmetric carbon, or an optically active N-acyl-amino acid; separating and collecting a less soluble diastereomeric salt by utilizing the difference in solubilities of the formed two kinds of diastereomeric salts; decomposing the resulting salt; reacting the resulting (S)-4-[4-chlorophenyl)(2- pyridyl)methoxy]piperidine with an ester represented by the formula (V): ##STR15##wherein R represents a lower alkyl group, and W represents a leaving group such as a halogen atom and a reactive ester group,to obtain (S)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butanoic acid ester represented by the formula (VI): ##STR16##wherein R and * have the same meaning as defined above; hydrolyzing the resulting compound; and reacting the hydrolyzed compound with benzenesulfonic acid or benzoic acid to form a salt.