Patent ID: 6071538
Filing Date: 2000-06-06
Classification: A61K,A61Q,C07C,C07K

Abstract:
A method for preparing an orally administrable biologically active agent, said method comprising:exposing a biologically active agent, which can exist in (i) a native conformational state, (ii) a denatured conformational state. and (iii) an intermediate conformational state, to acomplexing perturbant to reversibly transform said biologically active agent to said intermediate state and to form a transportable suprarnolecular complex,said intermediate conformational state being reversible to said native state and said intermediate conformational state being between said native and denatured states,said perturbant having a molecular weight ranging from about 150 to about 600 daltons, and having at least one hydrophilic moiety and at least one hydrophobic moiety,said supramolecular complex comprising said perturbant non-covalently complexed with said biologically active agent; andsaid biologically active agent not forming a microsphere with said perturbant.