Patent ID: 6118010
Filing Date: 2000-09-12
Classification: C07C,C07K,Y02P

Abstract:
A process for preparing a 1-alkoxycarbonyl-3-phenylpropyl derivative represented by the formula (II): ##STR18## wherein R is an alkyl group, X is -Ala-, -Gly-, -Leu-, -Ile-, -Val-, -Orn-, -Lys- or -Hly-, in which .omega.-amino groups of -Orn-, -Lys- and -Hly- are protected with an acyl protecting group, Y is hydroxyl group, which comprises catalytically reducing a 1-alkoxycarbonyl-3-oxo-3-phenylpropyl derivative represented by the formula (I): ##STR19## wherein R, X and Y are the same as defined above; the above-mentioned catalytic reduction being carried out in an alcohol or a solvent containing the alcohol in the presence of a strong acid having a concentration of 0.4 to 5 N, the amount of the strong acid being at least 3 equivalents based on one equivalent of the 1-alkoxycarbonyl-3-oxo-3-phenylpropyl derivative (1 mole) to control formation of a 1-alkoxycarbonyl-3-cyclohexylpropyl derivative represented by the formula (III): ##STR20## wherein R, X and Y are the same as defined above.