Patent ID: 6812347
Filing Date: 2004-11-02
Classification: A61P,C07D

Abstract:
A process for the preparation of a compound of the formula (I): wherein:R1 is CN or CSNH2; X is N or CR4; R2 and R4 are each independently hydrogen or chloro; R3 is halo, haloalkyl, haloalkoxy or â€”SF5; R5 and R6 are each independently alkyl; and n is 0, 1 or 2; said process comprising: (a) in a first step, reacting a compound of the formula (II): â€ƒwherein R1, R2, R3, X, R5 and n are as defined above and W is H, with an inorganic metal salt or an organic base, to afford, as an intermediate, a salt of said compound of formula (II); and (b) in a second step, reacting said salt of said compound of formula (II) with an alkylating agent of the formula (III): R6â€”Yâ€ƒâ€ƒ(III) wherein R6 is as defined above and Y is a leaving group.