Patent ID: 8366660
Filing Date: 2013-02-05
Classification: A61K,A61L,A61M,A61P

Abstract:
1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising: an inflatable polyamide balloon; and a coating layer that adheres to an exterior surface of the inflatable polyamide balloon, wherein: the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive; the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, everolimus, docetaxel, and combinations thereof; the hydrophobic therapeutic agent is not enclosed in micelles or liposomes and is not encapsulated in polymer particles; the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan stearates, PEG sorbitan monolaurates, and PEG sorbitan monooleates; the ratio by weight of the at least one additive to the therapeutic agent in the coating layer is from about 0.05 to 100.