Patent ID: 9149433
Filing Date: 2015-10-06
Classification: A61K,B01J,B29B

Abstract:
1. A method for formation of a plurality of micro-prilled poloxamer particles comprising the steps of: a) providing at least one copolymer of ethylene oxide and propylene oxide having a general formula of HO(C b) heating the at least one copolymer of step a) to a temperature sufficient to reduce its viscosity to less than or equal to 1300 cps, provided that the temperature is less than a char temperature of the at least one copolymer of step a); c) atomizing the heated at least one copolymer from step b) by passing it through an atomizing nozzle and into one of a co-current or a counter-current prilling tower thereby forming a plurality of particles of said at least one copolymer, said plurality of particles having an average nominal diameter of less than or equal to 106 microns, wherein said plurality of particles are free of a medicament; and optionally d) sieving said plurality of particles formed in step c) and retaining the particles passing through a mesh screen having openings of about 106 microns.