Patent ID: 7498335
Filing Date: 2009-03-03
Classification: A61K,A61P

Abstract:
1. A method of producing an antiangiogenic or vascular permeability reducing effect in a warm-blooded animal in need of such treatment which comprises administering to the animal an effective amount of a compound of the formula (I): wherein Q wherein: m is 0, 1, 2, 3 or 4; each R wherein X 1 is a direct bond or is selected from O, S, SO, SO 2 , N(R 4 ), CO, CH(OR 4 ), CON(R 4 ), N(R 4 )CO, SO 2 N(R 4 ), N(R 4 )SO 2 , OC(R 4 ) 2 , SC(R 4 ) 2 and N(R 4 )C(R 4 ) 2 , wherein R 4 is hydrogen or (1-6C)alkyl, and Q 3 is aryl, aryl-(1-6C)alkyl, (3-7C)cycloalkyl, (3-7C)cycloalkyl-(1-6C)alkyl, (3-7C)cycloalkenyl, (3-7C)cycloalkenyl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, or (R 1 ) m is (1-3C)alkylenedioxy, wherein X 2 is a direct bond or is selected from CO and N(R 6 )CO, wherein R 6 is hydrogen or (1-6C)alkyl, and Q 4 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, wherein X 3 is a direct bond or is selected from O, S, SO, SO 2 , N(R 7 ), CO, CH(OR 7 ), CON(R 7 ), N(R 7 )CO, SO 2 N(R 7 ), N(R 7 )SO 2 , C(R 7 ) 2 O, C(R 7 ) 2 S and N(R 7 )C(R 7 ) 2 , wherein R 7 is hydrogen or (1-6C)alkyl, and Q 5 is aryl, aryl-(1-6C)alkyl, (3-7C)cycloalkyl, (3-7C)cycloalkyl-(1-6C)alkyl, (3-7C)cycloalkenyl, (3-7C)cycloalkenyl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, wherein X 4 is a direct bond or is selected from O and N(R 9 ), wherein R 9 is hydrogen or (1-6C)alkyl, and R 8 is halogeno-(1-6C)alkyl, hydroxyl-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl or di-[(1-6C)alkyl]amino-(1-6C)alkyl, (2-6C)alkanoylamino-(1-6C)alkyl or (1-6C)alkoxycarbonylamino-(1-6C)alkyl, or from a group of the formula: wherein X 5 is a direct bond or is selected from O and N(R 10 ), wherein R 10 is hydrogen or (1-6C)alkyl, and Q 6 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, and any Q 6 group optionally bears 1 or 2 substituents, which may be the same or different, selected from halogeno, (1-6C)alkyl and (1-6C)alkoxy, R Z is O, S, N(C≡N) or N(R Q wherein X 6 is a direct bond or is selected from O and N(R 13 ), wherein R 13 is hydrogen or (1-6C)alkyl, and R 12 is halogeno(1-6C)alkyl, hydroxy(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl or di-[(1-6C)alkyl]amino(1-6C)alkyl, or from a group of the formula: wherein X 7 is a direct bond or is selected from O, S, SO, SO 2 , N(R 14 ), CO, CH(OR 14 ), CON(R 14 ), N(R 14 )CO, SO 2 N(R 14 ), N(R 14 )SO 2 , C(R 14 ) 2 O, C(R 14 ) 2 S and C(R 14 ), wherein each R 14 is hydrogen or (1-6C)alkyl, and Q 7 is aryl, aryl-(1-6C)alkyl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl or heterocyclyl-(1-6C)alkyl, or Q 2 is optionally substituted with a (1-3C)alkylenedioxy group, wherein X 8 is a direct bond or is selected from O and N(R 16 ), wherein R 16 is hydrogen or (1-6C)alkyl, and R 15 is halogeno-(1-6C)alkyl, hydroxyl-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, cyano-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl or di-[(1-6)alkyl]amino-(1-6C)alkyl, or a pharmaceutically acceptable salt thereof.