Patent ID: 8871707
Filing Date: 2014-10-28
Classification: A61K,A61P,A61Q

Abstract:
1. A method for improving appearance or elasticity of a tissue comprising: administering to a mammal in need thereof an effective amount of a composition comprising a population of cultured dermal fibroblasts, wherein said population of cultured dermal fibroblasts is pretreated with an elastin peptide fragment, wherein said elastin peptide fragment consists of a peptide having a sequence selected from the group consisting of PGGVLPG (SEQ ID NO: 47), VGVVPG (SEQ ID NO: 48), IGLGPGGV (SEQ ID NO: 49), VGAMPG (SEQ ID NO: 51), VGLSPG (SEQ ID NO: 52), IGAMPG (SEQ ID NO: 54), IGVAPG (SEQ ID NO: 55), IGLSPG (SEQ ID NO: 56), VGAMPGAAAAAVGAMPG (SEQ ID NO: 58), VGLSPGAAAAAVGLSPG (SEQ ID NO: 59), VGVAPGAAAAAVGVAPG (SEQ ID NO: 60) IGAMPGAAAAAIGAMPG (SEQ ID NO: 61), IGVAPGAAAAAIGVAPG (SEQ ID NO: 62), IGLSPGAAAAAIGLSPG (SEQ ID NO: 63), GXXPG (SEQ ID NO: 2), and a combination thereof.