Patent ID: 8183385
Filing Date: 2012-05-22
Classification: C07D

Abstract:
1. A process for preparing a compound of Formula Ia-2 or a salt or solvate thereof, wherein: R R R X X R or R R reacting a compound of Formula Va or Vb wherein X in the presence of a base to provide a compound of Formula VII-1a wherein A is —NR 3 R 3a or a compound of Formula VII-1b wherein A is N 3 reducing said compound of Formula VII-1a or VII-1b to provide a compound of Formula VIII-1 wherein when A of said compound of Formula VII-1a or VII-1b is N 3 , NH-benzyl, NH-allyl, then NHR 3 of said compound of Formula VIII-1 is NH 2 ; cyclizing said compound of Formula VIII-1 to provide a compound of Formula Ia-1 converting the nitrile group of said compound of Formula Ia-1 to COOR