Patent ID: 7611886
Filing Date: 2009-11-03
Classification: C12P

Abstract:
1. A process for the selective conversion of the (R)-epimer substrate in a mixture comprising either: (a) (S)-I, (1S,5R,6R,7R)-6-[(3S)-3-hydroxy-5-phenyl-1-pentenyl]-7-[(4-benzoyl)oxy]-2-oxabicyclo[3,3,0]octan-3-one and (R)-I, (1S,5R,6R,7R)-6-[(3R)-3-hydroxy-5-phenyl-1-pentenyl]-7-[(4-benzoyl)oxy]-2-oxabicyclo[3,3,0]octan-3-one, or (b) (S)-III, (1S,5R,6R,7R)-6-[(3R)-3-acetoxy-5-phenyl-1-pentenyl]-7-[(4-benzoyl)oxy]-2-oxabicyclo[3,3,0]octan-3-one and (R)-III, (1S,5R,6R,7R)-6-[(3R)-3-acetoxy-5-phenyl-1-pentenyl]-7-[(4-benzoyl)oxy]-2-oxabicyclo[3,3,0]octan-3-one, wherein, for (a), the mixture is combined with an acetylating agent in the presence of a lipase to form an acetylation reaction mixture, wherein the (R)-I substrate is selectively converted to (R)-III, and, for (b), the mixture is combined with a C