Patent ID: 6020329
Filing Date: 2000-02-01
Classification: C07D,Y02P

Abstract:
A compound of formula (I) or a salt thereof: ##STR23## wherein R.sup.1 is hydrogen, methoxy or formamido; R is an acyl group;CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group;R.sup.4 represents hydrogen or up to four substituents selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, amino, alkylamino, acylamino, dialkylamino, CO.sub.2 R, CONR.sub.2, SO.sub.2 NR.sub.2 (where R is hydrogen or C.sub.1-6 alkyl) and aryl, which may be the same or different and wherein any R.sup.4 alkyl substituent is optionally substituted by any other R.sup.4 substituent;X is S, SO, SO.sub.2, O or CH.sub.2 ;m is 1 or 2;n is 0;""acyl"" is selected from the group consisting of formula (a) to (f): ##STR24## wherein p is 0, 1 or 2; m is 0, 1 or 2;A.sub.1 is (C.sub.1-6)alkyl, substituted (C.sub.1-6)alkyl, (C.sub.3-6)cycloalkyl, cyclohexenyl, cyclohexadienyl, or an aromatic group;X.sub.1 is a hydrogen or halogen atom, a carboxylic acid, carboxylic ester, sulphonic acid, azido, tetrazolyl, hydroxy, acyloxy, amino, ureido, acylamino, heterocyclylamino, guanidino or acylureido group;A.sub.2 is an aromatic or a substituted alkyl group, or a substituted dithietane;X.sub.2 is a --CH.sub.2 OCH.sub.2 --, --CH.sub.2 SCH.sub.2 -- or alkylene group;X.sub.3 is an oxygen or sulphur atom;A.sub.3 is an aryl or heteroaryl group; andA.sub.4 is hydrogen, (C.sub.1-6)alkyl, (C.sub.3-8)cycloalkyl, (C.sub.3-8)cycloalkyl(C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, carboxy(C.sub.1-6)alkyl, (C.sub.2-6)alkynyl, aryl or (C.sub.1-6)alkyl substituted by up to three aryl groups.