Patent ID: 6632423
Filing Date: 2003-10-14
Classification: A61K,A61L,A61P

Abstract:
A method of inhibiting or reducing fibrosis and/or adhesion in traumatized tissues, comprising the administration of a tissue stabilizing effective amount of a viscoelastic agent to the traumatized tissue, wherein said agent is characterized by a viscosity (V0) of at least 30 Pa.s, and a cohesion-dispersion index (CDI) greater than zero and less than 20, such that the product of said viscosity and cohesion dispersion index afford a retention factor (R) of at least 600 in accordance with the formula:V0Ã—CDIÃ—R; and wherein the viscoelastic agent comprises a polymer or polymers selected from the group consisting of: modified or unmodified sodium hyaluronate, chondroitin sulfate, polyacrylamide carbomers, hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone, proteoglycans, collagen, methylcellulose, carboxymethyl cellulose, ethylcellulose, keratin, and combinations thereof.