Patent ID: 6500941
Filing Date: 2002-12-31
Classification: A61K,A61P,C07K,Y02A,Y10S

Abstract:
An isolated nucleic acid molecule which is selected from the group consisting of:(a) nucleic acid comprising the nucleotide sequence of the coding region of the &ggr;-HRG gene in SEQ ID NO:1; (b) nucleic acid encoding the polypeptide encoded by SEQ ID NO:1, yet having a nucleotide sequence differing from SEQ ID NO:1 due to the degeneracy of the genetic code; and (c) nucleic acid which hybridizes to DNA complementary to DNA encoding the N-terminal domain (NTD) of human &ggr;-HRG of SEQ ID NO:2 under moderately stringent conditions of overnight incubation at 37Â° C. in a solution comprising: 20% formamide, 5Ã—SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5Ã—Denhardt's solution, 10% dextran sulfate, and 20 mg/mL denatured sheared salmon sperm DNA, followed by washing the filters in 1Ã—SSC at about 37-50Â° C., and which said nucleic acid encodes a polypeptide which activates an ErbB receptor.