Patent ID: 6410749
Filing Date: 2002-06-25
Classification: C07B,C07C,C07D

Abstract:
A process for preparing optically active &bgr;-amino alcohols represented by a general formula (2);Raâ€”C*H(OH)â€”C*H(Rb)â€”Rcâ€ƒâ€ƒ(2) wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aralkyl or optionally substituted aryl, Rb is one member selected from among groups represented by the following general formulae; (3) R1CO(R2)Nâ€”, and (4) R1CO(R1â€²CO)Nâ€”, wherein R1, R1â€² and R2 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkoxy, optionally substituted alkenyl, optionally substituted aralkyl, optionally substituted aralkyloxy, optionally substituted aryl or optionally substituted aryloxy, or alternatively R1 and R2 or R1 and R1â€² may be united to form a five- to eight-membered nitrogenous heterocycle, and C* is an asymmetric carbon atom, characterized by reacting a racemic &agr;-aminocarbonyl compound represented by the general formula (1); Raâ€”COâ€”CH(Rb)â€”Rcâ€ƒâ€ƒ(1) wherein Ra, Rb and Rc are each as defined above, with hydrogen in the presence of an optically active transition metal compound represented by a general formula (7); MaXY(Px)m(Nx)nâ€ƒâ€ƒ(7) wherein Ma represents a metal atom belonging to VIII-group of the periodic law, X and Y represent each independently hydrogen, halogeno, carboxyl, hydroxide or alkoxy, Px represents a phosphine ligand, Nx represents an amine ligand, at least one of Px and Nx is optically active, and m and n each independently represent 0 or an integer of 1 through 4 and a base.