Patent ID: 7235659
Filing Date: 2007-06-26
Classification: A61P,C07D

Abstract:
1. A process for preparing compounds of formula 7 or a pharmaceutically acceptable salt thereof, wherein; L is alkylene; R is aryl, heteroaryl, R Y is —N(R and Z is aryl, R R 6 —SO 2 —, R 5 -aryl-CH(OH)— or aryl-CH(OH)—; or when Q is Z is also phenylamino or pyridylamino; or Z and Y together are R R m and n are each independently 2 or 3; Q is R R R R R R and R comprising a) halogenating and formylating a compound of formula 6 to obtain a compound of formula 5 wherein X is halogen (b) coupling the compound of formula 5 with a hydrazine of formula 4 in the presence of a base to form a compound of formula 3 (c) reacting the compound of formula 3 with a compound of formula HO-L-NHNH (d) concurrently (1) cyclizing and (2) halogenating the compound of formula 2 by reacting the compound of formula 2 in the presence of catalytic amount of a metal halide or a catalytic amount of a halide salt and a dehydrating agent to form a compound of formula 1 wherein A is halogen; and (e) preparing the compound of formula 7 by coupling the compound of formula 1 with a compound of formula 8 in the presence of a base.