Patent ID: 8834875
Filing Date: 2014-09-16
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a hematologic cancer in a human subject comprising administering to the subject a therapeutically effective amount of an antibody that specifically binds human Notch1, wherein the hematologic cancer is selected from the rout of acute myelogenous leukemia, Hodgkin lymphoma, multiple myeloma, and T-cell acute lymphoblastic leukemia, and wherein the antibody comprises: (a) a heavy chain CDR1 comprising RGYWIE (SEQ ID NO:15); a heavy chain CDR2 comprising QILPGTGRTNYNEKFKG (SEQ ID NO:16); and a heavy chain CDR3 comprising FDGNYGYYAMDY (SEQ ID NO:17); and (b) a light chain CDR1 comprising RSSTGAVTTSNYAN (SEQ ID NO:18); a light chain CDR2 comprising GTNNRAP (SEQ ID NO:19); and a light chain CDR3 comprising ALWYSNHWVFGGGTKL (SEQ ID NO:20).