Patent ID: 6154706
Filing Date: 2000-11-28
Classification: G01N,G16H,G16Z

Abstract:
A method of using a computer processor to predict a residual hormone concentration in a patient after a removal of a portion of the patient's tissue which secretes the hormone, the method comprising the following steps:(a) providing first, second and third measured hormone concentrations corresponding to first, second and third animal fluid samples taken from a patient at first, second and third sample times, respectively;(b) assigning an estimated value to the residual hormone concentration of the patient that is to be predicted;(c) determining an expression in half lifes of the second sample time, using the estimated value of step (b);(d) determining an expression in half lifes of the third sample time, using the determined expression in half lifes of the second sample time of step (c) and a ratio of the third sample time and the second sample time;(e) determining a hormone concentration that would remain at the second sample time if the residual hormone concentration were zero, using the determined expression in half lifes of the second sample time;(f) calculating a difference between the determined hormone concentration and the third measured hormone concentration;(g) remembering the estimated value for the residual hormone concentration as an old estimated value;(h) finding a new estimated value for the residual hormone concentration, using the calculated difference of step (f);(i) repeating steps (c) through (g) until a difference or percent change between the old estimated value and the new estimated value reaches a predetermined value; and(j) outputting the new estimated value of step (I) as the predicted residual hormone concentration.