Patent ID: 6171781
Filing Date: 2001-01-09
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
A method for identifying a compound which modulates translocation of an NF-AT polypeptide across the nuclear membrane of a cell by binding of the compound to the NF-AT polypeptide, comprising(i) contacting test compounds with an NF-AT polypeptide, or portion thereof, wherein the NF-AT polypeptide is encoded by a nucleic acid which hybridizes to a nucleic acid having SEQ ID NO: 45 in 5.times.SSC at 42.degree. C.;(ii) identifying those test compounds which bind to the NF-AT polypeptide; and(iii) determining which of the test compounds so identified modulates translocation of an NF-AT polypeptide across the nuclear membrane of a cell.