Patent ID: 7998954
Filing Date: 2011-08-16
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein n represents 1 or 2, Z represents a hydrogen atom, hydroxy, or optionally substituted lower alkoxy, R A represents a bond, (CH R (wherein R R wherein the substituent(s) of the optionally substituted lower alkyl, the optionally substituted lower alkoxy, and the optionally substituted lower alkoxycarbonyl are selected from the group consisting of wherein the substituent(s) of the optionally substituted aryl, the optionally substituted aromatic heterocyclic group, the optionally substituted aroyl, the optionally substituted aromatic heterocyclic carbonyl, the optionally substituted phenylene, and the optionally substituted pyridinediyl are selected from the group consisting of: wherein the substituent(s) of the optionally substituted cycloalkyl, the optionally substituted heterocyclic group, the optionally substituted aliphatic heterocyclic group, and the optionally substituted nitrogen-containing heterocyclic group formed with an adjacent nitrogen atom are selected from the group consisting of: wherein the substituent group A means a group consisting of halogen, hydroxy, sulfanyl, nitro, cyano, carboxy, carbamoyl, C the substituent group B means a group consisting of halogen, hydroxy, sulfanyl, nitro, cyano, carboxy, carbamoyl, C wherein the aliphatic heterocyclic group and the aliphatic heterocyclic group moiety of the aliphatic heterocyclic carbonyl is (1) a five-membered or six-membered monocyclic aliphatic heterocyclic group having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; or (2) a bicyclic or tricyclic fused aliphatic heterocyclic group with three- to eight-membered rings fused together, having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; the aromatic heterocyclic group and the aromatic heterocyclic group moiety of the aromatic heterocyclic carbonyl and the aromatic heterocyclic carbamoyl are (1) a five-membered or six-membered monocyclic aromatic heterocyclic group having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; or (2) a bicyclic or tricyclic fused aromatic heterocyclic group with three- to eight-membered rings fused together, having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; the heterocyclic group is (1) a five-membered or six-membered monocyclic aliphatic heterocyclic group having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; (2) a bicyclic or tricyclic fused aliphatic heterocyclic group with three- to eight-membered rings fused together, having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; (3) a five-membered or six-membered monocyclic aromatic heterocyclic group having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; or (4) a bicyclic or tricyclic fused aromatic heterocyclic group with three- to eight-membered rings fused together, having at least one atom selected from a nitrogen atom, an oxygen atom, and a sulfur atom; and the nitrogen-containing heterocyclic group formed with an adjacent nitrogen atom is (1) a five-membered or six-membered monocyclic heterocyclic group having at least one nitrogen atom; or (2) a bicyclic or tricyclic fused heterocyclic group with three- to eight-membered rings fused together, having at least one nitrogen atom; or a pharmaceutically acceptable salt thereof.