Patent ID: 7598262
Filing Date: 2009-10-06
Classification: A61K,A61P,Y10S

Abstract:
1. A method for first line treatment of type 2 diabetes, in a drug naïve human patient who has had no previous oral hyperglycemic treatment, which comprises administering to a drug naïve human patient in need of treatment, as first line therapy, a low dose of a combination of metformin and glyburide in a single dosage form, wherein the starting daily dosage is 250 mg metformin and 1.25 mg glyburide, where the glyburide has a particle size distribution so that at most 25% of the particles of the glyburide are less than 11 μm and at most 25% of the particles of the glyburide are greater than 46 μm, wherein after the staffing daily dosage, the metformin in said low dose combination is administered in a daily dosage in an amount within the range from about 250 mg to about 750 mg, and the glyburide in said low dose combination is administered in a daily dosage in an amount within the range from about 0.5 mg to about 15 mg, and wherein the weight ratio of metformin to glyburide is about 200:1, wherein the low dose combination of metformin and glyburide provides at least substantially equivalent efficacy in treating type 2 diabetes in drug naïve patients, but with substantially reduced side effects as compared to prior art combinations of metformin and glyburide employed in substantially higher daily dosages.