Patent ID: 8658797
Filing Date: 2014-02-25
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R is selected from the group consisting of aryl, arylalkyl, optionally substituted with one or more independent R R R R R R R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are each independently selected from the group consisting of hydrogen, cyano, —NO 2 , —OR 101 , hydroxy, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxy, alkoxyalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl, —C(O)R 101 , —C(O)OR 101 , —C(O)NR 101 R 102 , —NR 101 R 102 , —NR 101 S(O) 2 R 102 , —NR 101 C(O)R 102 , —S(O) 2 R 102 , —SR 101 and —S(O) 2 NR 101 R 102 , each optionally independently substituted with one or more independent R 103 substituents; and R 101 , R 102 , and R 103 are each independently selected from the group consisting of hydrogen, cyano, —NO 2 , —OR 104 , hydroxy, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxy, alkoxyalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl, —C(O)R 104 , —C(O)OR 104 , —C(O)NR 104 R 105 , —NR 104 R 105 , —NR 104 S(O) 2 R 105 , —NR 104 C(O)R 105 , —S(O) 2 R 104 , —SR 104 and —S(O) 2 NR 104 R 105 , each optionally independently substituted with one or more independent R 103 substituents; or R 101 , R 102 , together with the atoms connecting the same, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103 substituents; and R