Patent ID: 6160129
Filing Date: 2000-12-12
Classification: A61K,A61P,C07C,C07D

Abstract:
An ophthalmic solution comprising a therapeutically effective amount of a cyclopentane heptane(ene)oic acid, 2 heteroarylalkenyl compound of formula III, or a pharmaceutically acceptable salt thereof, in admixture with a non-toxic, ophthalmically acceptable liquid vehicle, packaged in a container suitable for metered application ##STR48## wherein the hatched segments represent .alpha. bonds, the solid triangle represents a .beta. bond; the dashed bond represents a double bond or a single bond; R.sup.5 represents hydrogen or a lower alkyl radical having up to six carbon atoms; X is selected from the group consisting of --OR.sup.1 and --N(R.sup.1).sub.2 ; Y is .dbd.O or represents 2 hydrogen radicals; R.sup.1 is hydrogen or a lower alkyl radical having up to six carbon atoms; Z is selected from the group consisting of O and S, A is C when A is bonded directly to said alkenyl of said 2-heteroalkenyl of the compound and CR.sup.2 when A is not bonded directly to said alkenyl of said 2-hetero alkenyl of the compound; R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen, halogen, cyano and lower alkyl having from 1 to 6 carbon atoms; wherein at least two of the radicals represented by R.sup.2, R.sup.3 and R.sup.4 are halogen, cyano, or a lower alkyl radical having from 1 to 6 carbon atoms; and the 9, 11, or 15 alkyl esters thereof.