Patent ID: 6114334
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR206## or a pharmaceutically acceptable salt thereof in the form of an individual enantiomers, or racemates or other mixtures of enantiomers, in which HET represents a group of formula a) ##STR207## in which R.sub.1 represents hydroxy, an alkoxy group having 1 to 3 carbon atoms, or an amino group optionally substituted by one or two alkyl groups each having 1 to 3 carbon atoms; R.sub.2 and R.sub.3 independently represent an alkyl group having 1 to 6 carbon atoms optionally substituted by one or more halo, an alkenyl group having 2 to 6 carbon atoms optionally substituted by one or more halo, a cycloalkyl group having 3 to 6 carbon atoms, or phenyl, benzyl or a 5 or 6-membered heteroaryl group having 1 to 3 heteroatoms selected from O, N and S wherein the phenyl, benzyl or heteroaryl group may be optionally substituted by one or more substituents selected from a) halo, b) an alkyl group having 1 to 3 carbon atoms optionally substituted by one or more halo, c) an alkoxy group having 1 to 3 carbon atoms optionally substituted by one or more halo, d) an alkylthio group, an alkylsulphinyl group or an alkylsulphonyl group each having 1 to 3 carbon atoms optionally substituted by one or more halo, e) hydroxy, f) an acyloxy group having 1 to 3 carbon atoms, g) a hydroxyalkyl group having 1 to 3 carbon atoms, h) cyano, i) an alkanoyl group having 1 to 6 carbon atoms, j) an alkoxycarbonyl group having 2 to 6 carbon atoms, k) a carbamoyl group or a carbamoylmethyl group each optionally N-substituted by one or two alkyl groups each having 1 to 3 carbon atoms, l) a sulphamoyl or sulphamoylmethyl group each optionally N-substituted by one or two alkyl groups each having 1 to 3 carbon atoms, or m) an amino group optionally substituted by one or two alkyl groups each having 1 to 3 carbon atoms; and Ar represents phenyl, pyridyl, pyrimidinyl, naphthyl, 1,4-benzodioxin-5-yl, 1,4-benzodioxan-5-yl, benzo[b]furan-7-yl, 2,3-dihydrobenzo[b]furan-7-yl, benzo[b]thiophen-7-yl, 2,3-dihydrobenzo[b]thiophen-7-yl or chroman-8-yl each of which may be optionally substituted by one or more substituents selected from a) halo, b) an alkyl group having 1 to 3 carbon atoms optionally substituted by one or more halo, c) an alkoxy group having 1 to 3 carbon atoms optionally substituted by one or more halo, d) an alkylthio group, an alkylsulphinyl group or an alkylsulphonyl group each having 1 to 3 carbon atoms optionally substituted by one or more halo, e) hydroxy, f) an acyloxy group having 1 to 3 carbon atoms, g) a hydroxyalkyl group having 1 to 3 carbon atoms, h) cyano, i) an alkanoyl group having 1 to 6 carbon atoms, j) an alkoxycarbonyl group having 2 to 6 carbon atoms, k) a carbamoyl group or a carbamoylmethyl group each optionally N-substituted by one or two alkyl groups each having 1 to 3 carbon atoms, l) a sulphamoyl or sulphamoylmethyl group each optionally N-substituted by one or two alkyl groups each having 1 to 3 carbon atoms, or m) an amino group optionally substituted by one or two alkyl groups each having 1 to 3 carbon atoms; and A represents an alkylene chain having 1 to 6 carbon atoms each of which may be optionally substituted by one or two alkyl groups each having 1 to 3 carbon atoms.