Patent ID: 6440956
Filing Date: 2002-08-27
Classification: C07D

Abstract:
A metal chelate of a compound of formula whereinR has the formula â€ƒand Z is a bond or a group selected from the group consisting of CH2, CH2â€”COâ€”NH and (CH2)2â€”NHâ€”CO, Zâ€² is a bond or a radical selected from the group consisting of O, S, NQ, CH2, CO, COâ€”NQ, NQâ€”CO, NQâ€”COâ€”NQ and COâ€”NQâ€”CH2â€”COâ€”NQ, Zâ€³ is a bond or a radical selected from the group consisting of COâ€”NQ, NQâ€”CO and COâ€”NQâ€”CH2â€”COâ€”NQ groups, p and q are integers, the sum of which has a value from 0 to 3, R1, R2, R3, R4, R5, independently of one another, are selected from the group consisting of H, Br, Cl, I, COâ€”NQ1Q2 and NQ1â€”COâ€”Q2, Q1 and Q2, which are identical or different, being H or (C1-C6) alkyl optionally interrupted by one or more oxygen atoms and at least one of the R1 to R5 groups being an amido group, or R1, R3, and R5 are, independently of one another, H, Br, Cl or I, and R2 and R4, which are identical, have the formula such that Zâ€²â€³ is a radical selected from the group consisting of COâ€”NQ, COâ€”NQâ€”CH2â€”COâ€”NQ, COâ€”NQâ€”CH2, COâ€”NQ(CH2)2â€”NQâ€”CO and NQâ€”COâ€”NQ, and Râ€²1, Râ€²3 and Râ€²5, which are identical or different, are H, Br, Cl or I, and Qâ€²1 and Qâ€²2, which are identical or different, are H or (C1-C6) alkyl optionally interrupted/by one or more oxygen atoms, Q is H or (C1-C4) alkyl, the alkyl groups being optionally mono- or polyhydroxylated, and wherein the metal of the metal chelate is a paramagnetic ion, a radioactive ion, or a transmetallation-effecting ion.