Patent ID: 6159460
Filing Date: 2000-12-12
Classification: A61K,Y10S

Abstract:
A method for treating reperfusion injury comprising administering to a patient in need thereof a therapeutically effective amount of an interleukin-1 receptor antagonist (IL-1ra), wherein said IL-1ra comprises a polypeptide that inhibits IL-1 and is sufficiently pure such that at least a portion of the amino acid sequence of said polypeptide can be determined, wherein said polypeptide comprises(1) the following amino acid sequence:(U) Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Gluwherein (U) is nothing or Met; or(2) a sequence which is at least about 90% homologous to said amino acid sequence.