Patent ID: 6599892
Filing Date: 2003-07-29
Classification: A61P,C07D

Abstract:
A pharmaceutical composition comprising: a compound of formula (1) wherein n is 0 or 1; R1 and R2 are the same or different and are selected from the group consisting of a) hydrogen; b) linear or branched C1-10-alkyl; c) halogen; d) hydroxy-C1-10,-alkyl; e) C1-10-alkoxy; f) C2-10-alkanoyloxy; g) C2-10-alkene; h) C2-10-alkene substituted with one or more groups selected from the group consisting of chlorine, fluorine, bromine or phenyl; i) C1-10-alkoxycarbonyl; j) C1-10-alkoxycarbamido; k) Nâ€”C1-10-alkoxy-Nâ€”C1-10-alkylaminocarbonyl; l) halo-C1-10-alkyl; m) C6-10-aryl; n) C6-10-aryl substituted with one or more groups selected from the group consisting of ethyl. n-propyl, isopropyl, amino, methylamino and dimethylamino; o) a C2-10-heterocycle having from 1-3 heteroatoms selected from the group consisting of O, N and S; and, p) â€”COOH or â€”COOY, wherein Y is pharmaceutically acceptable cation; R3 is selected from the group consisting of 1) â€”COOH; 2) chlorine or fluorine; 3) trifluoromethyl; 4) â€”CHO; and, 5) â€”CH2M where M is selected from the group consisting of a) hydrogen; b) halogen; c) hydroxy; d) C1-10-alkoxy; e) C6-10-aryloxy; f) C6-10-aryl-C1-10-alkoxy; g) mercapto; h) mercapto substituted with one or more groups selected from the group consisting of methyl, ethyl or phenyl; i) C2-10-acylthio; j) C2-10-acyloxy or carbamoyloxy; k) C2-10-acyloxy or carbamoyloxy substituted with one or more groups selected from the group consisting of â€”COOH, aminophenyl, phenyl, C1-6-alkyl, chlorine, bromine or fluorine; l) a quaternary ammonium salt; m) amino or amido; and, n) amino or amido substituted with one or more groups selected from the group consisting of C1-10-alkyl groups; R4 is selected from the group consisting of a) hydrogen; and b) pharmaceutically acceptable cations; and a &bgr;-lactam antibiotic.