Patent ID: 6174547
Filing Date: 2001-01-16
Classification: A61K

Abstract:
A process for providing a sustained-release, liquid formulation dosage form, wherein the process comprises the steps as follows:(a) blending an osmotic hydrogel and an osmotically effective solute to provide a composition that increases in volume in the presence of an aqueous fluid;(b) blending a hydroxyalkylcellulose and water to provide a granulation solution;(c) spraying the granulation solution of step (b) onto the composition provided in step (a) to provide granules;(d) forming a blended, liquid mixture consisting essentially of a drug, a surfactant, and a member selected from the group consisting of a mono- and di-glyceride to provide a drug formulation that is liquid upon administration and is adapted to self-emulsify in an aqueous environment;(e) adding the drug formulation formed in step (d) to a capsule;(f) adding the sprayed composition of step (c) to the capsule;(g) coating the capsule with a semipermeable composition to provide a membrane permeable to an aqueous fluid; and(h) providing an exit in the membrane formed in step (g) for delivering the drug formulation at a sustained-release and controlled rate over an extended time from the dosage form and providing a self-emulsifying drug formulation to the environment of use.