Patent ID: 8663675
Filing Date: 2014-03-04
Classification: A61K

Abstract:
1. A method of tissue engineering for organ reconstruction comprising the steps of: injecting a matrix on or in an area of an organ or tissue in need of engineering or reconstruction, wherein the injectable matrix comprises a polymer and a stem cell niche comprising cup-shaped nanoparticles containing growth factors or physiological agents; permitting the creation of a three dimensional matrix system or network with the injected area of the organ or tissue as a whole matrix; allowing the migration of a plurality stem cells or tissue-specific progenitor cells to the three dimensional matrix system or network; wherein growth factors and physiological agents are released from the nanoparticles in the injected area of the organ or tissue; and permitting the proliferation and differentiation of the migrated plurality of stem cells or tissue-specific progenitor cells in the presence of a mechanical in-vivo stress; whereby the organ or tissue is constructed.