Patent ID: 6908903
Filing Date: 2005-06-21
Classification: A61K,B82Y

Abstract:
1. A method of delivering an active agent to a targeted in vivo site comprising: (a) administering to a recipient a first conjugate comprising a targeting moiety and a member of a ligand/anti-ligand binding pair; (b) thereafter administering to the recipient a clearing agent capable of directing the clearance of circulating first conjugate; and (c) subsequently administering to the recipient a second conjugate comprising an active agent and a ligand/anti-ligand binding pair member, wherein the second conjugate binding pair member is complementary to that of the first conjugate; wherein the clearing agent comprises: wherein the clearing agent is characterized by a molecular mass between about 2,000 and about 20,000 daltons, and directs clearance of the compound by a hepatic pathway.