Patent ID: 6040479
Filing Date: 2000-03-21
Classification: C07C

Abstract:
Process for the resolution of racemic 2-(o-chlorophenyl)-2-methylaminocyclohexanone of the formula: ##STR3## wherein * is an asymmetric carbon atom, which comprises the following steps:1) reaction of racemic 2-(o-chlorophenyl)-2-methylaminocyclohexanone with an enantiomeric form of tartaric acid,2) isolation of the formed tartaric acid salt of 2-(o-chlorophenyl)-2-methylaminocyclohexanone and3) reaction of the isolated tartaric acid salt of 2-(o-chlorophenyl)-2-methylaminocyclohexanone with an alkali, whereby an isomer of 2-(o-chlorophenyl)-2-methylaminocyclohexanone can be isolated,wherein steps 1 and 2 are carried out in water or in a mixture of water and an alcohol and/or ketone, ether or ester.