Patent ID: 8784626
Filing Date: 2014-07-22
Classification: G01N

Abstract:
1. A detection system for a bio-separation device in which bio-separation of a sample takes place, comprising: a separation channel having a first longitudinal axis along which the sample undergoes separation into sample components, and a detection zone defined along the separation channel through which sample components pass; a radiation source; a detector; an incident light guide having a second longitudinal axis, directing incident radiation from the radiation source to the detection zone, causing radiation to be emitted by sample components as they pass through the detection zone; and an emission light guide having a third longitudinal axis, collecting and directing emitted radiation from the detection zone to the detector, wherein the emission light guide and the incident light guide are positioned on opposite sides of the separation channel, and wherein the first, second and third longitudinal axis are substantially coplanar at least at or near the detection zone, wherein each of the second and third longitudinal axis makes an acute angle with respect to the first longitudinal axis, wherein at least one of the incident light guide and emission light guide comprises an optical fiber, and wherein the optical fiber has a terminating ball-end structure that is integral to the optical fiber in a unitary structure, and that is spaced apart from exterior of the separation channel.