Patent ID: 6639064
Filing Date: 2003-10-28
Classification: C07K

Abstract:
An isolated nucleic acid molecule comprising a nucteotide sequence consisting of SEQ ID NO. 3 wherein the sequence encodes a functional NRIF3 nuclear hormone receptor co-activator polypeptide, wherein the NRIF3 binds in a ligand dependent manner to thyroid hormone receptor (TR) and retinoid X receptor (RXR), but does not interact with retinoic acid receptor (RAR), vitamin D receptor (VDR), progesterone receptor (PR), glucocorticoid receptor (GR), and estrogen receptor (ER) in a yeast two hybrid assay system or in vitro, or both, which polypeptide contains an LxxIL (SEQ ID NO:2) module in its C-terminal domain.