Patent ID: 6552015
Filing Date: 2003-04-22
Classification: A61P,C07D

Abstract:
A compound of formula (I): or pharmaceutically acceptable salts thereof, wherein the group wherein, for each,A is (CH2)n where n is 1 or 2; E is selected from the group consisting of N, CH, Câ€”OH, Câ€”CN, Câ€”Oâ€”(C1-C6)alkyl, and Câ€”(C1-C6)alkyl; U is NH or NR3, where R3 is selected from the group consisting of (C1-C6)alkyl and C(&boxH;O)â€”(C1-C6)alkyl; k is 1 or 2; R1 and R2 are selected independently from H, (C1-C6)alkyl, halo, CN, nitro, CF3, â€”NHC(O)R6 and â€”OR7, where R6 and R7 are selected independently from H, (C1-C6)alkyl, a 5- to 7-membered aryl ring, and a 5- to 7-membered heteroaryl ring; or R1 and R2, if on adjacent carbon atoms, together with the atoms to which they are attached, if adjacent, form a carbocyclic or heterocyclic five- or six-membered ring; R4 and R5 are selected from H, (C1-C6)alkyl, halo, â€”CF3, nitro, â€”CN, â€”NHC(&boxH;O)R6, â€”OR7, a 5- to 7-membered aryl ring, and a 5- to 7-membered heteroaryl ring; where R6 and R7 are as defined above; V is CH, CR8, or N, where R8 is H, (C1-C6)alkyl, halo, â€”CF3, nitro, â€”CN, â€”NHC(&boxH;O)R6, â€”OR7, a 5- to 7-membered aryl ring, or a 5- to 7-membered heteroaryl ring; wherein R6 and R7 are as defined above; W is C(O); and Y is CH, CR1 or CR2, where R1 and R2 are as defined above.