Patent ID: 7105529
Filing Date: 2006-09-12
Classification: A61P,C07D

Abstract:
1. A method of treating the severity of alopecia side-effects of chemotherapy and/or radiation therapy, in a subject receiving such therapy, comprising administering to said subject an effective amount of a cyclin-dependent kinase II inhibitor, wherein said inhibitor is a compound of the formula (I) wherein X is N, CH, CCF R R further wherein R R further wherein R with the proviso that R R R and further wherein R R R R Aryl is phenyl, naphthyl, phenanthryl or anthracenyl; Cyc is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl, any one of which may have one or more degrees of unsaturation; Het is a saturated or unsaturated heteroatom ring system selected from the group consisting of benzimidazole, dihydrothiophene, dioxin, dioxane, dioxolane, dithiane, dithiazine, dithiazole, dithiolane, furan, imidazole, morpholine, oxazole, oxadiazole, oxathiazole, oxathiazolidine, oxazine, oxadiazine, piperazine, piperadine, pyran, pyrazine, pyrazole, pyridine, pyrimidine, pyrrole, pyrrolidine, tetrahydrofuran, tetrazine, thiadiazine, thiadiazole, thiatrizole, thiazine, thiazole, thiomorpholine, thiophene, thiopyran, triazine and triazole with the proviso that when R and the pharmaceutically acceptable salts, biohydrolyzable esters, biohydrolyzable amides, biahydrolyzable carbamates solvates, hydrates, affinity reagents or prodrugs thereof in either crystalline or amorphous form.