Patent ID: 6127381
Filing Date: 2000-10-03
Classification: C07B,C07D,C40B

Abstract:
An isoquinoline compound of the formula: ##STR2## wherein: R.sup.1 is selected from the group consisting of C.sub.1 to C.sub.9 alkylene, C.sub.1 to C.sub.9 substituted alkylene, C.sub.2 to C.sub.9 alkenylene, C.sub.2 to C.sub.9 substituted alkenylene, C.sub.2 to C.sub.9 alkynylene, C.sub.2 to C.sub.9 substituted alkynylene, C.sub.7 to C.sub.12 phenylalkylene, C.sub.7 to C.sub.12 substituted phenylalkylene and a group of the formula:--(CH.sub.2).sub.u --CH(NHR.sub.8)--wherein u is selected from a number 1 to 8; and R.sup.8 is selected from the group consisting of a hydrogen atom, C.sub.1 to C.sub.9 alkyl, C.sub.1 to C.sub.9 substituted alkyl, C.sub.7 to C.sub.12 phenylalkyl and C.sub.7 to C.sub.12 substituted phenylalkyl;R.sup.2 is selected from the group consisting of phenyl, substituted phenyl, naphthyl, substituted naphthyl, C.sub.7 to C.sub.12 phenylalkyl, C.sub.7 to C.sub.12 substituted phenylalkyl, a heterocyclic ring and a substituted heterocyclic ring;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently, a hydrogen atom, halo, hydroxy, protected hydroxy, cyano, nitro, C.sub.1 to C.sub.6 alkyl, C.sub.2 to C.sub.7 alkenyl, C.sub.2 to C.sub.7 alkynyl, C.sub.1 to C.sub.6 substituted alkyl, C.sub.2 to C.sub.7 substituted alkenyl, C.sub.2 to C.sub.7 substituted alkynyl, C.sub.1 to C.sub.7 alkoxy, C.sub.1 to C.sub.7 acyloxy, C.sub.1 to C.sub.7 acyl, C.sub.3 to C.sub.7 cycloalkyl, C.sub.3 to C.sub.7 substituted cycloalkyl, C.sub.5 to C.sub.7 cycloalkenyl, C.sub.5 to C.sub.7 substituted cycloalkenyl, a heterocyclic ring, C.sub.7 to C.sub.12 phenylalkyl, C.sub.7 to C.sub.12 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C.sub.2 to C.sub.7 alkylene, substituted cyclic C.sub.2 to C.sub.7 alkylene, cyclic C.sub.2 to C.sub.7 heteroalkylene, substituted cyclic C.sub.2 to C.sub.7 heteroalkylene, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, carboxamide, protected carboxamide, C.sub.1 to C.sub.4 alkylthio, C.sub.1 to C.sub.4 alkylsulfonyl, C.sub.1 to C.sub.4 alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl and substituted phenylsulfonyl;X is selected from the group consisting of hydroxy, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, an amino acid, aniline, substituted aniline, a heterocyclic ring, an aminosubstituted heterocyclic ring, and a heterocyclic ring substituted with secondary or tertiary amine; andY is selected from the group consisting of CH.sub.2 NHR.sup.7 and C(O)NHR.sup.7, wherein R.sup.7 is a hydrogen atom, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 substituted alkyl.