Patent ID: 9212212
Filing Date: 2015-12-15
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical composition comprising a complement receptor 2 (CR2)-factor H (FH) molecule comprising: a) a CR2 portion comprising a CR2 or a fragment thereof, and b) a FH portion comprising a FH or a fragment thereof, said FH portion or fragment thereof comprising at least the first four N-terminal short consensus repeat (SCR) domains of FH, wherein the CR2 portion of the CR2-FH molecule is capable of binding to a CR2 ligand; wherein the FH portion of the CR2-FH molecule is capable of inhibiting activation of the alternative complement pathway; and wherein said pharmaceutical composition comprises an amount of said CR2-FH molecule of about 0.01 μg/kg to about 300 mg/kg.