Patent ID: 8815299
Filing Date: 2014-08-26
Classification: A61K

Abstract:
1. A method for obtaining a natural mixture of conjugated equine estrogens depleted in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids and non-conjugated norisoprenoids, said method comprising: a) subjecting an aqueous initial phase, selected from the group consisting of to a liquid-liquid extraction with a sufficient quantity of an organic solvent extracting agent which is at most only slightly miscible with water thereby extracting non-conjugated lipophilic compounds, and subsequently separating a resulting aqueous phase, whereby the organic solvent extracting agent is selected from the group consisting of straight-chained, branched or cyclic C b) optionally repeating method step (a) with the resulting aqueous phase; c) recovering an aqueous phase containing the natural mixture of conjugated estrogens depleted in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids and non-conjugated norisoprenoids; d) distilling the recovered aqueous phase to remove residue of the organic solvent extracting agent; and e) retaining the distilled aqueous phase from step d) as a starting material for the preparation of medicaments.