Patent ID: 6159953
Filing Date: 2000-12-12
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A method of controlling malaria-causing Plasmodium parasites in a living mammalian host infected with such parasites which comprises administering to said living mammalian host (1) an effective amount of a compound which blocks the de novo pathway for the biosynthesis of the pyrimidine nucleotides essential for RNA and DNA synthesis in said parasites, said compound being selected from the group consisting of 5-fluoro-orotic acid, esters and amides of the aforementioned orotic acid, O-acyl and N-acyl derivatives of the aforementioned orotic acid, and cis and trans-5,6-dihydro counterparts and (2) a member of the group consisting of uracil, uridine, cytosine, cytidine, thymine, deoxythymidine and deoxycytidine in amount sufficient to minimize toxic effects caused by administration of said compound to said host.