Patent ID: 9211252
Filing Date: 2015-12-15
Classification: A61K,A61L,A61P

Abstract:
1. A method comprising: contacting a polymeric material consisting of silicone with a first solvent composition comprising butyl acetate to produce a pre-extracted silicone material, wherein the first solvent composition is free of antimicrobial agents; drying the pre-extracted silicone material to remove substantially all of the first solvent composition; and contacting the pre-extracted silicone material with a solution comprising one or both of minocycline and rifampin and a second solvent composition containing butyl acetate to incorporate the therapeutic agents into the pre-extracted polymeric material, wherein the first and second solvent compositions are the same or different, wherein the pre-extracted silicone material is free of minocycline and rifampin, and wherein the amount of the one or both of minocycline and rifampin incorporated into the pre-extracted polymeric material is greater than the amount of the one or both of the minocycline and rifampin that can be loaded into a control silicone polymeric material that has not been pre-extracted but that has been contacted with a solution comprising one or both of minocycline and rifampin under the same conditions as the pre-extracted polymeric material.