Patent ID: 8048409
Filing Date: 2011-11-01
Classification: A61K,C12N

Abstract:
1. A method of providing therapy to a blood vessel wall at an aneurysmal site, said therapy comprising the steps of: obtaining self-derived skeletal muscle; isolating cells from the self-derived skeletal muscle wherein the isolated cells are selected from the group consisting of myocytes, myoblasts, and a combination thereof; and delivering said isolated cells directly to the blood vessel wall at the aneurysmal site by a delivery means selected from the group consisting of (1) a cell-associated implant selected from the group consisting of a carrier or scaffold, cells encapsulated in biodegradable microspheres or capsules, and an implanted stent and a wrap comprised of cells embedded within a matrix or scaffold, applied either periadventially or intralumenally and (2) injection of cells directly into the vessel wall at the aneurysmal site; wherein said therapy results in one or more of inducing new muscle growth at the aneurysmal site, reducing inflammation at the aneurysmal site, regenerating extracellular matrix components in the medial or adventitial blood vessel layers at the aneurysmal site or inhibiting matrix metalloproteinases.