Patent ID: 8498822
Filing Date: 2013-07-30
Classification: C12Q,G16B,G16H

Abstract:
1. A method of classifying a therapeutic intervention for arresting or killing colorectal cancer (CRC) cells, comprising: (a) from a panel of CRC cells classified according to genomic subgroups, selecting at least one CRC cell line from each subgroup, wherein the panel is assembled from a method comprising: (b) contacting the at least one CRC cell from each subgroup with the therapeutic intervention; (c) assaying the effectiveness of the therapeutic intervention to arrest or kill the at least one CRC cell from each subgroup; (d) classifying the therapeutic intervention according to the determined effectiveness of the therapeutic intervention to arrest or kill the at least one CRC cell from each subgroup, wherein the plurality of samples, m, consists of HCT-8, LS174T, SK-CO-1, SW48, DLD-1, HCT-15, HCT116, LoVo, CL-34, CL-40, C170, LS180, Caco-2, LS1034, LS411N, LS513, NCI-H498, NCI-H747, SW1116, SW1417, SW837, HT-29, SW620, CL-11, CL-14, Colo-678, SW-480, Colo 320DM, NCI-H508, NCI-H716, SW1463, SW403, SW948, Colo205, and Colo-206F cell lines, and wherein arresting or killing the at least one CRC cell from one subgroup, but not another indicates specificity of the therapeutic intervention to arrest or kill CRC cells of that subgroup.