Patent ID: 6358947
Filing Date: 2002-03-19
Classification: A61P,C07D

Abstract:
A compound having the formula: wherein:R1 through R6 are independently hydrogen, F, Cl, Br, I, NO2, CN, OR10, NR10R11, SR10, COR12, CO2R12, CONR10R11, optionally substituted C1 to C6 alkyl or heteroalkyl, C1 to C6 haloalkyl, optionally substituted C3 to C8 cycloalkyl, optionally substituted C2 to C6 alkenyl or alkynyl, optionally substituted allyl, optionally substituted aryl or heteroaryl, or optionally substituted arylmethyl, where R10 and R11 are independently hydrogen, C1 to C6 alkyl or heteroalkyl or haloalkyl, aryl, heteroaryl, optionally substituted allyl, optionally substituted arylmethyl, COR13, SO2R13 or S(O)R13, where R12 is hydrogen, C1 to C6 alkyl or heteroalkyl or haloalkyl, aryl, heteroaryl, optionally substituted allyl or optionally substituted arylmethyl, where R13 is hydrogen, C1 to C6 alkyl or haloalkyl, aryl, heteroaryl, optionally substituted allyl or optionally substituted arylmethyl; R7 is hydrogen, C1 to C6 alkyl or haloalkyl or heteroalkyl, aryl, arylmethyl, heteroaryl, COR12, CO2R12, SO2R12, S(O)R12 or CONR10R11, where R10 to R12 have the same definitions given above; R8 and R9 are independently hydrogen, C1 to C6 alkyl or haloalkyl or heteroalkyl, optionally substituted C2 to C6 alkenyl or alkynyl, optionally substituted allyl, optionally substituted arylmethyl, optionally substituted aryl or optionally substituted heteroaryl; X is OCH2, SCH2, NHCH2, OC(O), SC(O), NHC(O), CH2O, CH2S, CH2NH, C(O)O, C(O)S or C(O)NH; Y is O, S or NR10, where R10 has the same definition given above; or a pharmaceutically acceptable salt thereof.