Patent ID: 8846670
Filing Date: 2014-09-30
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A product of formula (I): in which: R1 represents an -L-aryl or -L-heteroaryl radical, such that L represents: either a single bond, or a linear or branched alkyl radical containing from 1 to 6 carbon atoms and optionally substituted with a hydroxyl radical, or a CO or —CO-Alkyl-group, or an L′-X group where L′ represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms, and X an oxygen or sulphur atom; the aryl and heteroaryl radicals being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, CN, nitro, —COOH, —COOalkyl, —NRxRy, —CONRxRy, —NRxCORy, —NRxCO the alkoxy, phenoxy, alkylthio, alkyl and heterocycloalkyl radicals substituted on the aryl and heteroaryl radicals being themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and NRvRw; it being possible for the heterocycloalkyl and heteroaryl radicals to additionally contain an oxo radical; R2 represents a hydrogen atom or an alkyl radical; R3 represents a hydrogen atom or an alkyl radical optionally substituted with one or more halogen atoms; R4 represents a hydrogen atom or a halogen atom; NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NRvRw and heterocycloalkyl radicals; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted; NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy and heterocycloalkyl radicals; or Rv and Rw form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted; the cyclic radicals that Rx and Ry or Rv and Rw, respectively, can form with the nitrogen atoms to which they are attached, being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms, and alkyl, hydroxyl, oxo, alkoxy, NH Rz represents the values of Ry except for hydrogen; Rx, Ry and Rz, in the —NRxCORy, —CORy and NRxCO all the above alkyl, alkoxy and alkylthio radicals being linear or branched and containing from 1 to 6 carbon atoms, or racemic, enantiomeric or diastereoisomeric isomers thereof, or pharmaceutically acceptable salts of said product or racemic, enantiomeric or diastereoisomeric isomers.