Patent ID: 6262040
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A compound of the formula I ##STR15##or a pharmaceutically acceptable salt thereof, wherein:R is C.sub.1 -C.sub.9 cycloalkyl, wherein said R group is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, hydroxy, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, nitro, --CO.sub.2 R.sub.12, --C(O)NR.sub.12 R.sub.13, --NR.sub.12 R.sub.13 and --SO.sub.2 NR.sub.12 R.sub.13 ; where R.sub.12 and R.sub.13 are independently H or methyl;R.sub.1 is C.sub.1 -C.sub.9 alkyl, wherein said R.sub.1 group is optionally substituted by 1 to 3 substituents independently selected from the group consisting of methyl, ethyl, trifluoromethyl, and halo;R.sub.2 is --Z.sub.3 --R.sub.7 ; where:Z.sub.3 is --C(Y.sub.1)NR.sub.8 (CHR.sub.12).sub.n --, or --NR.sub.8 C(Y.sub.1)(CHR.sub.12).sub.n --, where Y.sub.1 is O, R.sub.8 is H, R.sub.12 is H, and n is 0 or 1; andR.sub.7 is phenyl or pyridyl, each optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, trifluoromethyl, nitro, cyano, --CO.sub.2 R.sub.12 where R.sub.12 is H or methyl, --OC(O)(C.sub.1 -C.sub.4 alkyl), --C(O)NH.sub.2, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy.