Patent ID: 8278421
Filing Date: 2012-10-02
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody that binds gastrin (gastrin 17) with an affinity kd of 10 −7 M or less that comprises: (a) a heavy chain CDR1 amino acid sequence set forth in SEQ ID NOs: 1, 3, 5, 7, 9, 11 or 23-33, a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution, or a consensus sequence thereof; (b) a heavy chain CDR2 amino acid sequence set forth in SEQ ID NOs: 1, 3, 5, 7, 9, 11 or 23-33, or a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution or a consensus sequence thereof; (c) a heavy chain CDR3 amino acid sequence set forth in SEQ ID NOs: 1, 3, 5, 7, 9, 11 or 23-33 or a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution, or a consensus sequence thereof; (d) a light chain CDR1 amino acid sequence set forth in SEQ ID NOs: 2, 4, 6, 8, 10 or 12, or a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution; (e) a light chain CDR2 amino acid sequence set forth in SEQ ID NOs: 2, 4, 6, 8, 10 or 12, or a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution; and (f) a light chain CDR3 amino acid sequence set forth in SEQ ID NOs: 2, 4, 6, 8, 10 or 12, or a variant thereof in which one or two amino acids have been changed by conservative amino acid substitution.