Patent ID: 6147065
Filing Date: 2000-11-14
Classification: A61P,C07J,Y10S

Abstract:
A method for inducing a contraceptive effect in a patient desiring such an effect, comprising orally administering a contraceptively effective amount of a 14,17-C.sub.2 -bridged steroid of formula (I): ##STR15## wherein R.sup.3 is O, a hydroxyimino group or two H atoms,R.sup.6 is H, fluorine, chlorine or bromine; or a C.sub.1 -C.sub.4 alkyl radical in the .alpha.- or .beta.-position and R.sup.6' and R.sup.7 are H atoms, orR.sup.6, is H, fluorine, chlorine or bromine; or a C.sub.1 -C.sub.4 alkyl radical and R.sup.6' and R.sup.7 form an additional bond, orR.sup.7 is a C.sub.1 -C.sub.4 alkyl radical in the .alpha.- or .beta.-position and R.sup.6 and R.sup.6' are H atoms, orR.sup.6 and R.sup.7 together form a methylene group in the .alpha.- or .beta.-position and R.sup.6' is H, orR.sup.6 and R.sup.6' together form an ethylene or methylene group and R.sup.7 is H,R.sup.9 and R.sup.10 each are H or form an additional bond,R.sup.11 and R.sup.12 each are H or form an additional bond,R.sup.13 is a methyl or ethyl group,R.sup.15 is H or a C.sub.1 -C.sub.3 -alkyl radical,R.sup.16 and R.sup.16' each independently are H, a C.sub.1 -C.sub.3 alkyl radical or a C.sub.2 -C.sub.4 -alkenyl radical, or together form a C.sub.1 -C.sub.3 alkylidene group,R.sup.15 and R.sup.16 form an additional bond and R.sup.16' is H or a C.sub.1 -C.sub.3 -alkyl radical, orR.sup.15 and R.sup.16 together form a ring of partial formula ##STR16## wherein n is 1 or 2,X is a methylene group or O, andR.sup.16' is H,R.sup.17.spsp.1 is H or a C.sub.1 -C.sub.3 -alkyl radical,R.sup.17.spsp.2 is H, a C.sub.1 -C.sub.3 alkyl radical or a C.sub.2 -C.sub.4 -alkenyl radical,R.sup.17.spsp.1' and R.sup.17.spsp.2' each are H or form an additional bond,R.sup.21 is H or a C.sub.1 -C.sub.3 -alkyl radical,R.sup.21' is H, a C.sub.1 -C.sub.3 -alkyl radical or a hydroxy groupwith the proviso that the compound is not 14,17-ethano-19-norpregn-4-ene-3,20dione.