Patent ID: 6124270
Filing Date: 2000-09-26
Classification: A61K,A61P,Y10S

Abstract:
A transfection agent comprising(a) a cationic amphipathic compound of formula I: ##STR8## where in A represents a single bond, an NH--R' group, or an ##STR9## group, where --R'-- is an aliphatic chain containing from 1 to 22 carbon atoms, which is linear or branched, optionally substituted, saturated or unsaturated, optionally interrupted by one or more heteroatoms O, S, N, as well as by one or more aromatic or saturated or unsaturated heterocyclic or carbocyclic radicals,R.sub.1, R.sub.2, R.sub.3 are identical or different and each represent a higher alkyl or acyl group,R.sub.7, R.sub.8, R.sub.9 are identical or different and each represent an alkylene radical (CH.sub.2).sub.n where 1.ltoreq.n.ltoreq.6,R.sub.4, R.sub.5, R.sub.6 are identical or different and each represent:a hydrogen atom,an alkyl, alkenyl, alkynyl or acyl radical containing from 1 to 22 carbon atoms, which is optionally substituted, optionally interrupted by one or more heteroatoms chosen from O, S, N or by one or more aromatic or saturated or unsaturated heterocyclic or carbocyclic radicals,or alternatively, at least 2 of the groups R.sub.4, R.sub.5 and R.sub.6 form together with the nitrogen atom to which they are linked a quinuclidino, piperidino, pyrrolidino or morpholino group,X is a nontoxic anion; and,(b) at least one plasmid or polynucleotide.