Patent ID: 9090628
Filing Date: 2015-07-28
Classification: A61P,C07D

Abstract:
1. A compound selected from 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-2-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; (cis)-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-2-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; (trans)-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-2-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 10-((4-tert-butylpiperazin-1-yl)methyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)benzenesulfonamide; (4-tert-butylpiperazin-1-yl)(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methanone; 9-((S)-2-((S)-1-methylpiperidin-2-yl)pyrrolidin-1-yl)-2-(pyridin-2-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(piperidin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-phenyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-sulfonamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)-N-phenylacetamide; N-benzyl-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)acetamide; 10-(4-tert-butylpiperazin-1-ylsulfonyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(3-morpholinoazetidin-1-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (S)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(2-(1-methylpiperidin-3-yl)pyrrolidin-1-yl)-2-(pyridin-2-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(4-isopropylpiperazin-1-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(2-(piperidin-1-ylmethyl)pyrrolidin-1-yl)-2-(pyridin-2-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-1-ylsulfonyl)-N,N-dimethylpiperidin-4-amine; 1-(dihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-ylsulfonyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (S)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(4-(pentan-3-yl)piperazin-1-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(pyridin-4-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-((1-methylpiperidin-2-yl)methoxy)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfonyl)piperazin-1-yl)-2-methylpropan-1-ol; 10-(1-tert-butylpiperidin-4-ylthio)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-tert-butylpiperidin-4-ylsulfinyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-tert-butylpiperidin-4-ylsulfonyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylpiperidin-4-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (R)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidin-2-yl)-N,N-dimethylmethanamine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(4-methylpiperazin-1-yl)ethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(4-methylpiperazin-1-yl)ethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (S)-10-(1-(4-tert-butylpiperazin-1-yl)ethyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (R)-10-(1-(4-tert-butylpiperazin-1-yl)ethyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)ethyl)piperidin-4-yl)propan-2-ol; 10-(1-tert-butylpiperidin-4-ylthio)-2-(pyridin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-tert-butylpiperidin-4-ylthio)-2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (S)-10-(1-tert-butylpiperidin-4-ylsulfinyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-tert-butylpiperidin-4-ylthio)-2-(3-methyl-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-tert-butylpiperidin-4-ylthio)-2-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(3-morpholinoazetidin-1-yl)ethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylazetidin-3-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(1-(3-fluoropyridin-4-yl)ethoxy)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)ethyl)-N,N-dimethylazetidin-3-amine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(4-methylpiperazin-1-yl)propyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-(4-methylpiperazin-1-yl)propyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-isopropylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylthio)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfinyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(4-(2,2,2-trifluoro-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)ethyl)piperidin-1-yl)ethanone; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylpiperidin-4-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylazetidin-3-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(1-(3-fluoropyridin-4-yl)ethoxy)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfinyl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfonyl)piperidin-1-yl)-2-methylpropan-1-ol; 9-(1-(2,4-dimethylthiazol-5-yl)ethoxy)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-((4-tert-butylpiperazin-1-yl)methyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine; 10-((4-tert-butylpiperazin-1-yl)methyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 3-(1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)ethyl)benzonitrile; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfonyl)piperidin-1-yl)-2-methylpropanamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfinyl)piperidin-1-yl)-2-methylpropanamide; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(4-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl)ethanone; 10-(1-isopropylpiperidin-4-ylthio)-2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-methyl-2-(4-(2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfinyl)piperidin-1-yl)propan-1-ol; 10-(1-isopropylpiperidin-4-ylsulfinyl)-2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-methyl-2-(4-(2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfonyl)piperidin-1-yl)propan-1-ol; 10-(1-isopropylpiperidin-4-ylsulfonyl)-2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(1-(2-(1-isopropyl-4-methyl-1H-imidazol-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)ethyl)piperidin-4-yl)propan-2-ol; (4-tert-butylpiperazin-1-yl)(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepin-10-yl)methanone; 10-(1-isopropylpiperidin-4-ylsulfinyl)-2-(3-methylpyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-isopropylpiperidin-4-ylsulfonyl)-2-(3-methylpyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfinyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylthio)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfinyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfonyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfinyl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-(oxetan-3-yl)piperidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1′-methyl-2,4′-bipiperidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylpiperidin-4-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-isopropylazepan-4-yl)ethoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(1-isopropylpiperidin-3-yloxy)-2-(pyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfonyl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(4-(9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-ylsulfinyl)piperidin-1-yl)-2-methylpropanamide; 1-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol; 10-(1-isopropylpiperidin-4-ylsulfinyl)-2-(4-methylpyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 10-(1-isopropylpiperidin-4-ylsulfonyl)-2-(4-methylpyridin-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfinyl)-9-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1′-methyl-2,4′-bipiperidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-2-(1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(2-methoxypropyl)-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (4-tert-butylpiperazin-1-yl)(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepin-10-yl)methanone; 1-tert-butyl-4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-10-carbonyl)piperazin-2-one; 9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfinyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-methyl-5-(9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-1-yl)ethanol; 2-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1-methyl-1H-pyrazol-5-yl)pyrrolidin-1-yl)-2-methylpropan-1-ol; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-methylpiperidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-10-carbonyl)-1-(tetrahydro-2H-pyran-4-yl)piperazin-2-one; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-isopropylpiperidin-4-ylsulfinyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-isopropylpiperidin-4-ylsulfonyl)-9-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-methylpiperidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-5-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)-2-methyl-1-(4-methylpiperazin-1-yl)propan-1-one; 2-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-methylpropanamide; 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(1-methylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-(1-methylpiperidin-4-yl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(5-(9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-1-yl)ethanol; 9-(1-(1-tert-butylpiperidin-4-yl)-1H-1,2,4-triazol-5-yl)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-((4-methylpiperazin-1-yl)methyl)cyclopropoxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-isopropyl-5-methylpiperidin-3-yloxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-isopropyl-3-methylpyrrolidin-3-yloxy)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(1-(1-benzylpiperidin-3-yl)-1H-pyrazol-5-yl)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (R)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-isopropylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-methyl-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; (S)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2-(1-isopropylpiperidin-4-yl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-(5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(1-(2-methoxypropyl)-1H-1,2,4-triazol-5-yl)-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; and 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(5-(1-isopropylpiperidin-3-yl)-1-methyl-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine.