Patent ID: 8926491
Filing Date: 2015-01-06
Classification: A61B,A61K,A61N,A61P,B82Y,C12Y,H01F,Y10S

Abstract:
1. A method of increasing fluid flow within vasculature of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the vasculature, the method comprising: introducing a therapeutic agent within vasculature of a subject; infusing a plurality of magnetic nanoparticles within the vasculature in a manner such that dispersion of the magnetic nanoparticles within a solution is maintained during infusion, causing a magnet external to the vasculature and having a magnetic field and a directed magnetic gradient to be positioned and to rotate in a manner sufficient to i) agglomerate the magnetic nanoparticles into a plurality of agglomerates within the vasculature and ii) travel within the vasculature toward a therapeutic target in an end over end manner in response to the rotating magnetic field and the directed magnetic gradient of the magnet; and causing the agglomerates to collectively generate a circulating fluid motion within the vasculature proximal to the therapeutic target by adjusting at least one parameter selected from the group consisting of: a rotational frequency of the rotating magnetic field, a plane of the rotating magnetic field with respect to the therapeutic target, and a distance of the rotating magnetic field with respect to the therapeutic target, wherein the circulating fluid motion facilitates contact of the therapeutic agent with the therapeutic target by enhancing diffusion of the therapeutic agent to the therapeutic target and by refreshing contact of the therapeutic target with the therapeutic agent, thereby providing more effective interaction of the therapeutic agent with the therapeutic target.