Patent ID: 8354397
Filing Date: 2013-01-15
Classification: A61K,A61P,C07D

Abstract:
1. A method for inhibiting activation of a hedgehog pathway in a cell, comprising contacting the cell with a hedgehog antagonist in a sufficient amount to inhibit hedgehog signaling, wherein the hedgehog antagonist is an organic molecule represented in the formula (II): wherein, as valence and stability permit, X represents —N(R Z represents —NH— or a direct bond; Y represents —C(═O)—, —C(═S)— or SO A represents O, or —NH—; G represents a phenyl or pyridyl ring fused to the ring to which it is attached; R R R R J represents, independently for each occurrence, a chain having from 0-8 units selected from CK provided that, when J is CK provided that, when R or a pharmaceutically acceptable salt thereof.