Patent ID: 6063962
Filing Date: 2000-05-16
Classification: C07C,Y02P

Abstract:
A process for the production of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR7## wherein: R.sup.1 and R.sup.2 are independently phenyl or 4-fluorophenyl;R.sup.3 is hydrogen, alkyl C.sub.1-4 or methoxycarbonyl;R.sup.4 is hydrogen or methyl;which comprises reaction of a compound of formula II: ##STR8## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in formula (I), with a compound of formula (III): ##STR9## in which R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are independently C.sub.1-6 alkyl to give a compound of formula (IV): ##STR10## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8, R.sup.9 and R.sup.10 are as defined in formula (I), followed by deprotection and optionally thereafter forming a pharmaceutically acceptable salt.