Patent ID: 6096888
Filing Date: 2000-08-01
Classification: A61K,A61P,C07C,C07D

Abstract:
An anthracyclinone of formula A: ##STR41## wherein R.sub.1 represents: hydrogen or hydroxy; ora group of formula OR.sub.6 in which R.sub.6 is C.sub.1 -C.sub.6 alkyl, C.sub.5-6 cycloalkyl or CH.sub.2 Ph with the phenyl (Ph) ring optionally substituted by 1, 2 or 3 substituents selected from F, Cl, Br, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 alkoxy and CF.sub.3 ;R.sub.2 represents hydrogen, hydroxy, OR.sub.6, COOH or COOR.sub.6 wherein R.sub.6 is as above defined;R.sub.3 represents hydrogen, hydroxy, or OR.sub.6 as above defined;R.sub.4 represents a group of formula XCH.sub.2 R.sub.8 in which X is CO ##STR42## in which R.sub.8 is: a group of formula NR.sub.9 R.sub.10 in which:R.sub.9 and R.sub.10 together with the nitrogen atom to which they are attached form:(f) A morpholino ring optionally substituted with C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy,(g) a piperazino ring optionally substituted by C.sub.1 -C.sub.6 alyl, C.sub.2 -C.sub.6 alkenyl or phenyl optionally substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, F, Br, Cl, CF.sub.3, OH, NH.sub.2 or CN, or(h) a pyrrolidino, piperidino or tetrayhdropyridino ring optionally substituted by OH, NH.sub.2, COOH, COOR.sub.11 or CONR.sub.11 R.sub.12 wherein R.sub.11 and R.sub.12 are as above defined, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or phenyl optionally substituted by one of more substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, F, Br, Cl, CF.sub.3, OH, NH.sub.2 or CN;R.sub.5 represents hydrogen, hydroxy or a group of formula OR.sub.6or a pharmaceutically acceptable salt thereof.