Patent ID: 6458758
Filing Date: 2002-10-01
Classification: A61K,B82Y,C07K

Abstract:
A method to reduce the effect of free radical toxicity in a biological system comprising:administering a therapeutically active amount of a membrane permeable first nitroxide wherein the first nitroxide is selected from the group consisting of 4,4-Dimethyl-3-oxazolinyloxy-(DOXYL), 2,2,5,5-Tetramethyl-1-pyrrolidinyloxy-(PROXYL), and 2,2,6,6-Tetramethyl-1-piperidinyloxy-(TEMPOL), having a nitroxyl group which donates an electron to a second nitroxide, and administering an amount of the second nitroxide to extend the reactivity of the first nitroxide, wherein the second nitroxide is a polynitroxide macromolecule and has a nitroxyl group which accepts an electron from the first nitroxide.