Patent ID: 6723523
Filing Date: 2004-04-20
Classification: G01N

Abstract:
A system for monitoring the effect of extracellular chemical stimuli on the translational motion of cells, the system comprising:(a) an array of one or more cell containment wells; (b) an array of one or more chemical attractant wells containing a chemical attractant therein interspersed among the array of one or more cell containment wells; (c) one or more substantially planar sensing electrodes distributed within the arrays of cell containment wells and chemical attractant wells so that at least one of the sensing electrodes is between one cell containment well and one chemical attractant well, wherein the one or more sensing electrodes is operatively coupled to a sensing device capable of measuring an electrical parameter of the sensing electrode; (d) at least one counter electrode in electrical connection with the one or more sensing electrodes; and (e) a biocompatible chemical gradient stabilizing gel medium in simultaneous diffusional contact with the arrays of cell containment wells and chemical attractant wells.