Patent ID: 6652865
Filing Date: 2003-11-25
Classification: A61K,A61P

Abstract:
A method of decreasing statin metabolism within intestinal epithelium comprising formulating said statin with a self micro-emulsfying carrier, said self micro-emulsifying carrier comprising:a lipophilic phase comprising a mixture of glycerol mono-, di- and triesters and of PEG mono- and diesters with at least one fatty acid chosen from the group comprising C8-C18 fatty acids; a surfactant phase comprising a mixture of glycerol mono-, di- and triesters and of PEG mono- and diesters with caprylic acid (C8) and capric acid (C10); a co-surfactant phase comprising at least one ester of a polyvalent alcohol with at least one fatty acid chosen from the group comprising caprylic esters of propylene glycol, lauric esters of propylene glycol and oleic esters of polyglycerol, the ratio SA/CoSA being between 0.2 and 6.