Patent ID: 6201148
Filing Date: 2001-03-13
Classification: A61P,C07F

Abstract:
A process for the preparation of alendronic acid, which comprises the steps of:a) reacting a compound of the formula I with H.sub.3 PO.sub.3 ##STR6##whereinR is an imido group; andR.sup.1 is selected from the group which consists of chloro, bromo, iodo, fluoro, hydroxy, amino, --OR.sup.2 or --OC(O)R.sup.2, wherein R.sup.2 is C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 cycloalkyl, or C.sub.1 -C.sub.12 aryl;b) reacting the product of step (a) with a deprotecting agent; andc) recovering alendronic acid.