Patent ID: 9140689
Filing Date: 2015-09-22
Classification: C07K,G01N

Abstract:
1. A method for identifying a tumor cell in a subject as susceptible or resistant to an inhibitor of fibroblast growth factor receptor (FGFR2) to induce tumor cell death, inhibit tumor growth, or decrease risk of metastasis of a tumor cell comprising: receiving a sample from the subject; and detecting the presence of at least one mutation variant of FGFR2 having the sequence of SEQ ID NO: 2, wherein the mutation variant is chosen from M536I, M538I, I548V, N550H, N550K, N550S , V565I, E566G, L618M, and Y770IfsX14 in the sample from the subject; determining the presence of the at least one mutation variant of FGFR2, wherein the presence of the at least one of the mutation variant of FGFR2 indicates that the tumor cell from the subject is resistant to the inhibitor; and