Patent ID: 8735437
Filing Date: 2014-05-27
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein: X and Y are independently —C(R3)(R4)-, —(C═O)—, or —(C═S), provided that at least one of X and Y is —(C═O)—or —(C═S)—, and X and Y cannot both simultaneously be —(C═O)—or —(C═S)—, or X and Y together are C(R3)=C(R3); R is —(C═O )—NR1aR2a, —(C═O)—O—R1b, (C R and X when X is —C(R3)(R4)-, together with the nitrogen atom to which they are attached form a monocyclic, saturated or partly unsaturated 4- to 7-membered ring system or a bicyclic saturated or partly unsaturated 8- to 14-membered ring system whose individual members of the ring systems may be replaced by one to three atoms or atomic groups selected from —CHR11-, —CR11R12-, —(C═R11)-, =C(R11)-, —NR11-, —C(=O)-, —O—, —S—, —SO—, and —SO m, m′ and m″ are independently 0, 1, 2, 3, 4, 5, or 6; R5, R6, R7, R8, R9 and R10 are independently hydrogen or (C R11 and R12 are independently hydrogen, (C n is 0, 1, 2, 3, 4, 5, or 6; R13, R14 and R15 are independently hydrogen or (C R1, R1a and R1b are independently (C o and o′ are independently 0, 1, 2, 3, 4, 5, or 6; R16, R17, R18, R19, R20 and R21 are independently hydrogen or (C R1, Rla and Rlb may independently be a radical of formula Ia wherein: W is —C(R28)(R29)-, —C(R28)(R29)—C(R28a)(R29a)-, or —C(R28)(R29)—O—; R22, R23, R24, R25, R26, R27, R28, R29, R28a, R29a are independently hydrogen, F, Cl, Br, I, OH, CF R22 and R28 or R23 and R29 together with the carbon atoms to which they are attached form a monocyclic, 5 or 6 membered saturated, partly unsaturated or aromatic ring system whose individual members may be replaced by —CHR33-, —CR33R34-, or =(C—R33)-; or R24 and R26, or R25 and R27 together with the carbon atoms to which they are attached form a monocyclic, 5 or 6 membered saturated, partly unsaturated or an aromatic ring system whose individual members may be replaced by —CHR33-, —CR33R34-, or =(C—R33)-; p is 0, 1, 2, 3, 4, 5, or 6; R30, R31 and R32 are independently hydrogen or (C R33 and R34 are independently F, Cl, Br, I, OH, CF q is 0, 1, 2, 3, 4, 5, or 6; R35, R36 and R37 are independently hydrogen or (C R2 and R2a are independently hydrogen or (C R3 and R4 are independently hydrogen, (C or a tautomeric form or a physiologically tolerated salt thereof; provided that R1 is not pentyl, CH