Patent ID: 8052990
Filing Date: 2011-11-08
Classification: A61L,C08J

Abstract:
1. A process for the production of a biocompatible crosslinked polydensified monophasic gel, consisting of successive steps of: (a) starting a crosslinking reaction of a predetermined quantity of at least one biocompatible polymer in solution by the addition of a quantity of crosslinking agent in a first volume of a reaction mixture, (b) crosslinking said quantity of polymer, (c) adding a supplemental quantity of polymer of a molecular weight higher than 500,000 Da in solution with dilution of the reaction mixture so as to decrease an overall concentration of the polymer in a second volume of the reaction mixture, (d) continuing crosslinking in the second volume of the reaction mixture, and (e) stopping the crosslinking reaction by elimination of the crosslinking agent, to produce the polydensified monophasic gel.