Patent ID: 8404678
Filing Date: 2013-03-26
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: provided that when and when R1, R2, R1′, R2′ are the same or different and independently chosen from H, halide or alkyl optionally substituted by one or more Hal, CN, NRR′, CF B and B′ are the same or different and independently chosen from Alkenyl being optionally substituted by one or more Hal, CN, NRR′, CF X, X′ are —O—; A, A′ are the same or different and independently chosen from Alkyl or Alkenyl, each being optionally substituted by one or more Hal, CN, NRR′, CF Y, Y′ are the same or different and independently chosen from H, OR; T is —NR— or a 4 to 10-membered aryl, cycloalkyl, heterocyclic, heteroaryl or a linear or branched alkyl, each being substituted by one or more non-cleavable linker(s) and optionally substituted by one or more of Hal, CN, NRR′, CF n, n′, equal or different, are 0 or 1; q is 0, 1 or 2; and R, R′ are equal or different and independently chosen from H, Alkyl, Aryl, each being optionally substituted by Hal, CN, COOH, COOR, CONHR, CONRR′, NRR′, CF wherein the linker: (A) is of formula -G-D-(Z) (B) is selected from the group consisting of: —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(C≡C)—(CR —O(CR —O(CR —O(CR —O-phenyl-QCOZ′R″, —O-furyl-QCOZ′R″, —O-oxazolyl-QCOZ′R″, —O-thiazolyl-Q COZ′R″, —O-thienyl-QCOZ′R″, —O-imidazolyl-QSCOZ′R″, —O-morpholino-QCOZ′R″, —O-piperazino-QCOZ′R″, —OCO(CR —OCO—(CR —OCONR —OCO-phenyl-QCOZ′R″, —OCO-furyl-QCOZ′R″, —OCO-oxazolyl-QCOZ′R″, —OCO-thiazolyl-QCOZ′R″, —OCO-thienyl-QCOZ′R″, —OCO-imidazolyl-QCOZ′R″, —OCO-piperazino-QCOZ′R″, or —CO(CR —CO—(CR —CONR —CO-phenyl-QCOZ′R″, —CO-furyl-QCOZ′R″-CO-oxazolyl-QCOZ′R″, —CO-thiazolyl-QCOZ′R″, —CO-thienyl-QCOZ′R″, —CO-imidazolyl-QCOZ′R″, —CO-piperazino-QCOZ′R″, —CO-piperidino-QCOZ′R″, —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —NR —S(O) —S(O) —SCONR wherein: (C) —C(═O)—Z′R″ is a carbonyl containing function wherein Z′ represents a single bond or —O—, —S—, —NR— and R″ represents H, Alkyl, Cycloalkyl, Aryl, heteroaryl or heterocyclic, each being optionally substituted by one or more Hal, CN, NRR′, CF or a pharmaceutically acceptable salt thereof; or optical isomers, racemates, diastereomers or enantiomers of said compound.