Patent ID: 6365140
Filing Date: 2002-04-02
Classification: A61K,A61Q,C08B,C08L

Abstract:
An aqueous solution of a modified starch comprising:(a) about 20% to about 98.599%, by weight water; (b) about 1% to about 49.5%, by weight of a modified starch; (c) about 0.2% to about 15%, by weight of urea; (d) about 0.2% to about 10% by weight of an alpha hydroxy acid or the corresponding alpha hydroxy acid salt with sodium, ammonium, potassium, and/or substituted amine; (e) zero up to about 5% by weight of an aliphatic carboxylic acid from C2 to C36 in chain length acid or the corresponding carboxylic acid salt with sodium, ammonium and/or potassium; (f) about 0.001% to about 0.5% by weight of a preservative; and (g) having a pH of from about 1 to 9 wherein the modified starch of (b) is of the general formula: wherein R1 is selected from the group consisting of ethers (1,2,3 and 4), ester (5) and amphoteric stubstituents (6, 7, 8 and 9) generally described as:â€ƒâ€”CH2â€”(â€”CHR2â€”)mâ€”CH2â€”N+(CH3)3Xâˆ’â€ƒâ€ƒ(1)wherein m is an integer from 0 to 34, each R2 can independently be H or OH, and Xâˆ’ is Clâˆ’ or Brâˆ’;â€”CH2â€”(â€”CHR3â€”)mâ€”CR3H2â€ƒâ€ƒ(2) wherein m is as defined above and each R3 can independently be H or OH;â€”(â€”CH2â€”CHR4â€”Oâ€”)nâ€”CH2â€”(â€”CHR5â€”)mâ€”CH2â€”N+(CH3)3Xâˆ’â€ƒâ€ƒ(3) wherein n is an integer from 1 to 100, m is as defined above, each R4 can independently be H, OH, CH3 or CH2OH, each R5 can independently be H or OH, and Xâˆ’ is Clâˆ’ or Brâˆ’;(â€”CH2â€”CHR6â€”Oâ€”)nâ€”CH2â€”(â€”CHR7â€”)mâ€”CR7H2â€ƒâ€ƒ(4) wherein n and m are as defined above, each R6 can independently be H, OH, CH3 or CH2OH, each R7 can independently be H or OH, and Xâˆ’ is Clâˆ’ or Brâˆ’;â€”COâ€”(â€”CHR8)mâ€”C R8H2â€ƒâ€ƒ(5) wherein m is as defined above and each R8 can independently be H, OH, CH3 or CH2OH;â€”CH2â€”(â€”CHR9â€”)mâ€”CH2â€”N+(R10)3â€ƒâ€ƒ(6) wherein m is as defined above, each R9 can independently be H, OH, CH3 or CH2OH, and each R10 can independently be:(A) â€”(CR11Hâ€”)pâ€”CH3 (B) â€”CH2OH (C) â€”(CR11Hâ€”)pâ€”COOH (D) â€”(CR11Hâ€”)pâ€”COOâˆ’(E) â€”(CR11Hâ€”)pâ€”SO3âˆ’wherein p is an integer from zero to 10 and each R11 can independently be H, OH, CH3 or CH2OH;â€”CH2â€”(â€”CHR9â€”)mâ€”CH2â€”COâ€”NHâ€”CH2â€”CH2â€”CH2â€”N+(R10)3â€ƒâ€ƒ(7) wherein m, R9, and R10 are as defined above;â€”COâ€”CH2â€”(â€”CHR9â€”)mâ€”CH2â€”N+(R10)3â€ƒâ€ƒ(8) wherein m, R9, and R10 are as defined above;â€”COâ€”CH2â€”(â€”CHR9â€”)mâ€”CH2â€”COâ€”NHâ€”CH2â€”CH2â€”CH2â€”N+(R10)3â€ƒâ€ƒ(9) wherein m, R9 and R10 are as defined above;wherein the mol % of substituted sugar units (w) out of the total sugar units along the starch molecule is between about 2 mol % to about 80 mol % and the mol % of unsubstituted sugar units (x) is between about 20 mol % to about 98 mol %.