Patent ID: 7879858
Filing Date: 2011-02-01
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: (3-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; cyclopentyl-[1-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; benzo[1,3]dioxol-5-yl-[1-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; (2-methoxy-phenyl)-[1-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; (1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(furan-2-yl)methanone; cyclopropyl(1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (3-fluoro-phenyl)-[1-(2-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; (1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(o-tolyl)methanone; benzo[d][1,3]dioxol-5-yl(1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; cyclopentyl-(1-o-tolyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; o-tolyl(1-o-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; benzo[d][1,3]dioxol-5-yl(1-o-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (4-fluoro-phenyl)-(1-m-tolyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; Thiophen-2-yl(1-m-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (3-fluoro-phenyl)-(1-m-tolyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; cyclopentyl(1-m-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; benzo[1,3]dioxol-5-yl-(1-m-tolyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; (1-(2,4-difluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(4-fluorophenyl)methanone; (4-fluorophenyl)(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(thiophen-2-yl)methanone; (3-fluorophenyl)(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; cyclopentyl(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; 2-methoxy-1-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone; (1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(o-tolyl)methanone; (2-methoxyphenyl)(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; cyclobutyl(1-(4-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; (1-(4-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(2-methoxyphenyl)-methanone; furan-2-yl(1-(3-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (2-fluorophenyl)(1-o-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; benzo[1,3]dioxol-5-yl-[1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; [1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-o-tolyl-methanone; [1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(2-fluoro-phenyl)-methanone; [1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-thiophen-2-yl-methanone; [1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-furan-2-yl-methanone; [1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(4-fluoro-phenyl)-methanone; (1-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(2-methoxyphenyl)methanone, benzo[d][1,3]dioxol-5-yl(1-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (1-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(o-tolyl)-methanone; (1-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)yl)(cyclopentyl)-methanone; [1-(3-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(3-fluoro-phenyl)-methanone; [1-(3-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(2-fluoro-phenyl)-methanone [1-(3-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-thiophen-2-yl-methanone; [1-(3-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(4-fluoro-phenyl)-methanone; (2-fluorophenyl)(1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; (2-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; (1-(4-(dimethylamino)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(o-tolyl)-methanone; (1-(4-(dimethylamino)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(2-fluorophenyl)methanone; cyclopropyl(1-(4-(dimethylamino)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (1-(4-(dimethylamino)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-(thiophen-2-yl)methanone; (1-(4-(dimethylamino)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(4-fluorophenyl)methanone; 2-methoxy-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)butan-1-one; benzo[1,3]dioxol-5-yl-(1-thiophen-2-yl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; (1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)yl)(o-tolyl)methanone (3-fluoro-phenyl)-(1-thiophen-2-yl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)-methanone; cyclopropyl(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; (4-fluorophenyl)(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; benzo[1,3]dioxol-5-yl-4[-(3,4-dichloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; cyclopentyl-[1-(3,4-dichloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-methanone; [1-(3,4-dichloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-(2-fluoro-phenyl)-methanone; 1-(1-(3,4-dichlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-3-methylbutan-1-one; (1-(3,4-Dichlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(thiophen-2-yl)-methanone cyclobutyl(1-(3,4-dichlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone 1-(1-(3,4-dichlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-methylpropan-1-one; [1-(3,4-dichloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-furan-2-yl-methanone; (2-fluorophenyl)(1-p-tolyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; (3-methylthiophen-2-yl)(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-methanone; 3-(2,4-difluorophenyl)-1-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-prop-2-en-1-one; 3-phenyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)prop-2-en-1-one; 3-(4-fluorophenyl)-1-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)prop-2-en-1-one; 1-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-3-(4-(trifluoromethylthio)-phenyl)prop-2-en-1-one; (1-(4-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(o-tolyl)methanone; 3-phenyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)propan-1-one; 5-phenyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)pentan-1-one; 1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)hexan-1-one; phenyl(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; 1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone; 2-phenyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-ethanone; 3,3-dimethyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-butan-1-one; 3-cyclohexyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-propan-1-one, and 4-phenyl-1-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)butan-1-one, and pharmaceutically acceptable salts thereof.