Patent ID: 6696087
Filing Date: 2004-02-24
Classification: A61K,A61P

Abstract:
A tablet comprising crystalline cellulose and/or low substituted hydroxylpropylcellulose and a phosphate-binding polymer, said phosphate-binding polymer being a polymer selected from the group consisting of(a) a polymer with a repeating unit having the formula or a copolymer thereof, wherein n is an integer and each R, independently, is H or a lower alkyl, alkylamino, or aryl group;(b) a polymer with a repeating unit having the formula or a copolymer thereof, wherein n is an integer and each R, independently, is H or a lower alkyl, alkylamino or aryl group, and each X is an exchangeable negatively charged counterion selected from the group consisting of organic ions, inorganic ions or combinations thereof;(c) a copolymer according to (b) with a first repeating unit having the formula wherein n is an integer, each R, independently, is H or a lower alkyl, alkylamino, or aryl group, and each X is an exchangeable negatively charged counterion selected from the group consisting of organic ions, inorganic ions or combinations thereof, and a second repeating unit having the formula wherein each n, independently, is an integer and each R, independently, is H or a lower alkyl, alkylamino, or aryl group;(d) a polymer with a repeating unit having the formula or a copolymer thereof, wherein n is an integer and R is H or a lower alkyl group, alkylamino, or aryl group;(e) a copolymer according to (b) with a first repeating unit having the formula: wherein n is an integer, and R is H or a lower alkyl, alkylamino, or aryl group, and a second repeating unit having the formula wherein each n, independently, is an integer, and R is H or a lower alkyl, alkylamino, or aryl group;(f) a polymer with a repeating unit having the formula or a copolymer thereof, wherein n is an integer, and each R1 or R2, independently, is H or a lower alkyl, alkylamino, or aryl group, and each X is an exchangeable negatively charged counterion selected from the group consisting of organic ions, inorganic ions or combinations thereof;(g) a polymer characterized by a repeating unit having the formula or a copolymer thereof, wherein n is an integer, and each R1 or R2, independently, is H, an alkyl group containing 1 to 20 carbon atoms, an alkylamino group, or an aryl group containing 1 to 12 atoms; and(h) a polymer with a repeating unit having the formula or a copolymer thereof, wherein n is an integer and each R1 and R3 independently, is H, an alkyl group containing 1 to 20 carbon atoms, an alkylamino group or an aryl group containing 1 to 12 atoms, and each X is an exchangeable negatively charged counterion selected from the group consisting of organic ions, inorganic ions or combinations thereof,which tablet has a hardness of 6 KP or more, and a disintegration time of 15 minutes or less.