Patent ID: 6599894
Filing Date: 2003-07-29
Classification: A61P,C07D

Abstract:
A compound of formula I, whereinR1 represents a N(R5)R6 or a S(O)mR7 substituent; R2 and R3 independently represent an optional substituent selected from halo, C1-4 alkyl or C1-4 alkoxy, which latter two groups are optionally substituted by halo; Y represents C1-3 alkylene, optionally substituted by C1-4 alkyl, methylene, &boxH;O or hydroxy; R4 represents H, OH, OR8a, C(O)OR8b or R8c; R5 represents C1-6 alkyl, optionally substituted by halo, or, together with R6 and the nitrogen atom to which R5 and R6 are attached, represents a 3- to 7-membered nitrogen containing ring, which ring optionally includes an oxygen atom and/or is optionally substituted with a &boxH;O group; R6 represents C1-6 alkyl, optionally substituted by halo, C(O)R9 or, together with R5 and the nitrogen atom to which R5 and R6 are attached, represents 3- to 7-membered nitrogen-containing ring, which ring optionally includes an oxygen atom and/or is optionally substituted with a &boxH;O group; or the group N(R5)R6 represents the structural fragment Ia, R6a represents one or more optional substituents selected from halo, C1-4 alkyl and C1-4 alkoxy, which latter two groups are optionally substituted by halo; X represents CH or N; m represents 0, 1 or 2; R7 represents H, NH2 or C1-6 alkyl; R8a and R8b independently represent C1-10 alkyl, C1-3 alkylphenyl or C6-10 aryl, or R8a represents C(R10a)(R10b)OC(O)R11, C(R10a)(R10b)N(H)C(O)OR12 or C(R10a)(R10b)OC(O)N(H)R12; R8c represents C(R10a)(R10b)OC(O)R11, C(R10a)(R10b)N(H)C(O)OR12 or C(R10a)(R10b)OC(O)R12; R10a and R10b independently represent, at each occurrence, H or C1-4 alkyl; R11 represents, at each occurrence, C6-10 aryl, OR12 or C1-7 alkyl, which latter group is optionally substituted by a substituent selected from OH, CO2H and C6-10 aryl; R12 represents, at each occurrence, C6-10 aryl or C1-6 alkyl, which latter group is optionally substituted by a substituent selected from OH, CO2H and C6-10 aryl; R9 represents C1-8 alkyl, Het1, C6-10 aryl or C1-4 alkyl substituted by C6-10 aryl; and Het1 represents a 4- to 12-membered heterocyclic ring, which ring contains one or more heteroatoms selected from oxygen, nitrogen and/or sulfur, and which ring may be fully saturated, partially saturated or aromatic and/or optionally monocyclic, bicyclic and/or benzo-fused; wherein each aryl/phenyl group and Het1 group identified above is optionally substituted by one or more halo, C1-4 alkyl and/or C1-4 alkoxy groups, which latter two groups are themselves optionally substituted by one or more halo groups; or a pharmaceutically acceptable salt thereof,provided that:(a) when m represents 1 or 2, then R7 does not represent H; and (b) when m represents 0, then R7 does not represent NH2.