Patent ID: 8481043
Filing Date: 2013-07-09
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition for nasal immunization comprising: a macrocyclic permeation enhancer, a liquid carrier, an emulsifying agent, and a therapeutically effective amount of an antigen; wherein said macrocyclic permeation enhancer is a Hsieh enhancer having the following structure: wherein X is oxygen, sulfur or an imino group of the structure wherein Y is oxygen, sulfur or an imino group of the structure ═N—R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, and each of R, R