Patent ID: 7674625
Filing Date: 2010-03-09
Classification: G01N,Y10T

Abstract:
1. A method for determining improper manipulation of a urine sample by a test subject during testing, wherein prior to providing the sample, the subject is administered marker substances PEG (polyethylene glycols) that are only slightly metabolizable or are non-metabolizable and thus detectable in urine. comprising: administering to the test subject, at the same time and in addition to the PEG marker substances, a metabolizable substance comprising at least one of a derivative of benzoic acid or 4-hydroxy-benzoic acid, that can be detected in the same chromatogram with the non-metabolizable PEG marker substances and that, after metabolism, is no longer detectable iii the sample in which the marker substances are analyzed; collecting a urine sample from the test subject; and analyzing the urine sample with chromatography, wherein the detection of the metabolizable substance in the urine sample demonstrates improper manipulation by the test subject.