Patent ID: 8809288
Filing Date: 2014-08-19
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A method of increasing immunoreactivity in a patient comprising: isolating at least one immune system cell from the patient; treating the cell, in vitro or ex vivo, with at least one Cbl-b inhibitor or antagonist to increase immunoreactivity of the cell; and reimplanting the cell in the patient; wherein the immune system cell is selected from the group consisting of antigen presenting cells, PBMCs, T-lymphocytes, B-lymphocytes, monocytes, macrophages, NK cells, NKT cells and dendritic cells; wherein the Cbl-b inhibitor or antagonist is selected from the group consisting of a short DNA sequence complementary to a part of the Cbl-b mRNA sequence and a short RNA sequence complementary to a part of the Cbl-b mRNA sequence; wherein the cell has optionally been contacted with an antigen; and wherein the immunoreactivity in the patient is increased by a transient reduction in or inhibition of the Cbl-b function of the cell.