Patent ID: 6211200
Filing Date: 2001-04-03
Classification: A61K,A61P,C07D,C07F

Abstract:
A method for agonizing the G-CSF receptor in a subject in need thereof which comprises administering to the subject a therapeutically effective amount of a G-CSF receptor binding moiety;except compounds of the formula: ##STR5##wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently aryl, where aryl is cyclic or polycyclic aromatic C.sub.3 -C.sub.12, optionally containing one or more heteroatoms, provided that when C is 3 the aromatic ring contains at least two heteroatoms, and when C is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of: C(O)NR.sup.6 R.sup.7 and NR.sup.6 R.sup.7, aryloxy, cycloalkyl, substituted cycloalkyl, akyl, C.sub.6 -C.sub.12 aryl, alkoxy, acyloxy, substituted C.sub.6 -C.sub.12 aryl, amino, N-acylamino, nitro, cyano, halogen, hydroxy, --C(O)OR.sup.6, --S(O).sub.n R.sup.5, protected --OH and alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, C.sub.6 -C.sub.2 aryl, substituted C.sub.6 -C.sub.12 aryl, amino, N-acylano, oxo, hydroxy, cycloalkyl, substituted cycloalkyl, --C(O)OR.sup.6, --S(O).sub.n R.sup.7, aryloxy, nitro, cyano, halogen and protected --OH, whereR.sup.6 is hydrogen or alkyl,n is 0-2,R.sup.7 is hydrogen or alkyl andR.sup.5 is hydrogen, cycloalkyl, C.sub.6 -C.sub.12 aryl substituted cycloalkyl, substituted C.sub.6 -C.sub.12 aryl, alkyl or alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, aryloxy, amino, N-acylamino, oxo, hydroxy, --C(O)OR.sup.6, --S(O).sub.n R.sup.7, nitro, cyano, cycloalkyl, substituted cycloalkyl, halogen, C.sub.6 -C.sub.12 aryl, substituted C.sub.6 -C.sub.12 aryl and protected --OH, where R.sup.6 is hydrogen or alkyl, n is 0-2 and R.sup.7 is hydrogen or alkyl; or a pharmaceutically acceptable salt, hydrate, solvate or ester thereof.