Patent ID: 6992169
Filing Date: 2006-01-31
Classification: A61K,A61P

Abstract:
1. A macromolecule comprising a drug moiety linked to a carrier moiety, wherein (a) the drug moiety is not a peptide, an oligonucleotide, cholesterol or biotin and is selected from the group consisting of a cardioprotective drug, an anti-arrhythmic drug, an anti-inflammatory drug, a neuroleptic drug, an anti-convulsant drug, an anxio-lytic drug, an antiviral drug, a diagnostic and a tri-substituted purine; (b) the carrier moiety is a homeobox peptide derived from the helix 3 sequence of the pAntp peptide or fragment thereof; and wherein the carrier moiety facilitates the cellular internalization of the drug moiety.