Patent ID: 6191171
Filing Date: 2001-02-20
Classification: C07C,C07D

Abstract:
A compound of formula Ia: ##STR35##whereinX is1) a bond, or2) C(R.sup.7)(R.sup.8);L is1) --S(O).sub.2 ;R.sup.1 is1) Cy, or2) Cy-C.sub.1-10 alkyl,wherein alkyl is optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ; orR.sup.1 -L is4-[N'-(2-methylphenyl)ureido]phenylacetyl;R.sup.2 is1) H or2) C.sub.1-5 alkyl;R.sup.4 is1) H or2) C.sub.1-5 alkyl;R.sup.5 is1) C.sub.1-10 alkyl,2) Cy-(Cy.sup.1).sub.p,3) Cy-(Cy.sup.1).sub.p -C.sub.1-10 alkyl,wherein alkyl is optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy and Cy.sup.1 are optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.7 is1) hydrogen, or2) C.sub.1-3 alkyl;R.sup.8 is1) hydrogen;R.sup.a is1) --CF.sub.3 ;2) --OR.sup.d,3) --NO.sub.2,4) halogen5) --S(O).sub.m R.sup.d,6) --CR.sup.d (N--OR.sup.e),7) --S(O).sub.2 OR.sup.d,8) --S(O).sub.m NR.sup.d R.sup.e,9) --NR.sup.d R.sup.e,10) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,11) --C(O)R.sup.d,12) --CO.sub.2 R.sup.d,13) --CO.sub.2 (CR.sup.f R.sup.g).sub.n CONR.sup.d R.sup.e,14) --OC(O)R.sup.d,15) --CN,16) --C(O)NR.sup.d R.sup.e,17) --NR.sup.d C(O)R.sup.e,18) --OC(O)NR.sup.d R.sup.e,19) --NR.sup.d C(O)OR.sup.e, or20) --NR.sup.d C(O)NR.sup.d R.sup.e ;R.sup.b is1) a group selected from R.sup.a,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, or6) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl, and Cy are optionally substituted with a group independently selected from R.sup.c ;substituted with a group independently selected from R.sup.c ;R.sup.c is1) halogen,2) amino,3) carboxy,4) C.sub.1-4 alkyl,5) C.sub.1-4 alkoxy,6) aryl,7) aryl C.sub.1-4 alkyl, or8) aryloxy;R.sup.d and R.sup.e are independently selected from the group consisting of1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy, and6) Cy C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R.sup.c ;R.sup.f and R.sup.g are independently selected from hydrogen, C.sub.1-10 alkyl, Cy and Cy C.sub.1-10 alkyl;R.sup.ba is1) halogen,2) C.sub.1-3 alkyl, or3) C.sub.1-3 alkoxy;Cy and Cy.sup.1 are independently cycloalkyl or aryl;m 0, 1 or 2;n integer from 1 to 10;p is 0 or 1; ora pharmaceutically acceptable salt thereof.