Patent ID: 6060049
Filing Date: 2000-05-09
Classification: A01K,A61K,A61P

Abstract:
A method for xenograft transplant of an organ to a recipient mammal from a donor mammal, wherein said recipient has increased immuno tolerance to donor tissue, comprising the steps of:a) collecting a first cell population from the recipient, said first cell population containing lymphocytic progenitor cells, wherein at least a portion of cells that are specifically cytotoxic to tissue from a surrogate animal are removed from said first cell population;b) administering said first cell population to said surrogate, said surrogate being in a state of immune deficiency;c) developing in said surrogate a state of immune competence;d) collecting from said immune competent surrogate a second population of cells, said second cell population containing immunocompetent cells, said immunocompetent cells specifically suppressing immune response of said recipient to tissue of said surrogate;e) infusing said second population of cells into said recipient;f) excising an organ from a donor mammal wherein the donor mammal is selected from the group consisting of the same surrogate mammal, the same inbred strain as the surrogate mammal and a littermate of the surrogate mammal; andg) transplanting said organ into said xenograft recipient.