Patent ID: 7649022
Filing Date: 2010-01-19
Classification: A61K,A61L

Abstract:
1. A composition comprising: a biodegradable linear polymer comprising at least one of the following: a poly(ester amide) (PEA) having a chemical formula described by general structural formula (I): wherein, n is about 10 to about 150; each R 1 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 12 ) epoxy-alkylene, residues of α,ω-bis(o,m, or p-carboxy phenoxy)-(C 1 -C 8 ) alkane, 3,3′-(alkenedioyldioxy) dicinnamic acid, 4,4′-(alkanedioyldioxy) dicinnamic acid, and combinations thereof; the R 3 s in each n monomer are independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl, and (CH 2 ) 2 SCH 3 ; and R 4 in each n monomer is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of general formula (II), and combinations thereof; a PEA having a chemical structure described by general structural formula (III), wherein m is about 0.1 to about 0.9; p is about 0.9 to about 0.1, n is about 10 to about 150, each R 1 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 12 ) epoxy-alkylene, residues of α,ω-bis(o,m, or p-carboxy phenoxy)-(C 1 -C 8 ) alkane, 3,3′-(alkenedioyldioxy) dicinnamic acid, 4,4′-(alkanedioyldioxy) dicinnamic acid, and combinations thereof; R 2 is independently selected from the group consisting of hydrogen, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl and a protecting group; each R 3 is independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl and (CH 2 ) 2 SCH 3 ; and each R 4 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of general formula II, and combinations thereof; and R 5 is independently (C 2 -C 20 ) alkyl or (C 2 -C 20 ) alkenyl; a poly(ester urethane) (PEUR) having a chemical formula described by structural formula (IV), wherein n ranges from about 5 to about 150; wherein the R 3 s in an individual n monomer are independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 6 -C 10 ) aryl(C 1 -C 6 ) alkyl and (CH 2 ) 2 SCH 3 ; R 4 and R 6 is selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II), and combinations thereof; a PEUR having a chemical structure described by general structural formula (V), wherein n ranges from about 5 to about 150, m ranges about 0.1 to about 0.9: p ranges from about 0.9 to about 0.1; R 2 is independently selected from the group consisting of hydrogen, (C 1 -C 12 ) alkyl, (C 2 -C 8 ) alkyloxy, (C 2 -C 20 ) alkyl (C 6 -C 10 ) aryl, and a protecting group; the R 3 s within an individual m monomer are independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl, and (CH 2 ) 2 SCH 3 ; R 4 and R 6 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II), and combinations thereof, and R 5 is independently selected from the group consisting of (C 1 -C 20 ) alkyl and (C 2 -C 20 ) alkenyl; a poly(ester urea) (PEU) having a chemical formula described by structural formula (VI), wherein n is about 10 to about 150; the R 3 s within an individual n monomer are independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl, and (CH 2 ) 2 SCH 3 ; R 4 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene, bicyclic-fragments of a 1,4:3,6-dianhydrohexitol of structural formula (II) and combinations thereof; and a PEU having a chemical formula described by structural formula (VII), wherein m is about 0.1 to about 1.0; p is about 0.9 to about 0.1; n is about 10 to about 150; each R 2 is independently hydrogen, (C 1 -C 12 ) alkyl, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkyl, (C 6 -C 10 ) aryl or a protecting group; and the R 3 s within an individual m monomer are independently selected from hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl and (CH 2 ) 2 SCH 3 ; R 4 is independently selected from (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, (C 2 -C 8 ) alkyloxy (C 2 -C 20 ) alkylene; bicyclic-fragments of a 1,4:3,6-dianhydrohexitol of structural formula (II), and combinations thereof, and R 5 is independently selected from the group consisting of (C 1 -C 20 ) alkyl and (C 2 -C 20 ) alkenyl; and at least one di- or poly-functional cross-linker that polymerizes upon exposure to a free radical and contains at least one hydrolyzable functional group, wherein the composition forms a semi-interpenetrating polymer network following exposure to active species.