Patent ID: 6410540
Filing Date: 2002-06-25
Classification: A61K,A61P,Y02A

Abstract:
A method to treat a condition mediated by p38&agr; kinase which method comprises administering to a subject in need of such treatment a compound of the formula: and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof,wherein Z is N or CR1, wherein R1 is selected from the group consisting of optionally substituted alkyl, alkoxy, aryl, arylalkyl, aryloxy, heteroaryl, amino, ureayl, carbamate, polyhaloalkoxy, halogen, acyl, carboxy, and hydroxy, each of X1 and X2 is a linker, wherein each said linker is independently saturated or unsaturated alkylene optionally containing 1-4 carbonyl, 1-4 SO2, and/or 1-3 heteroatoms, including a linker which is itself CO, SO2, SO or is itself a heteroatom, and said alkylene or suitable heteroatom optionally substituted with a substituent selected from the group consisting of halo, alkyl, alkoxy, cycloalkyl, aryl, aryloxy, arylalkyl, haloalkyl, polyhaloalkyl, haloalkoxy, polyhaloalkoxy, cycloheteroalkyl, cycloheteroalkylalkyl, heteroaryl, heteroarylalkyl, heteroaryloxy, arylthio, arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl, alkylaminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, acyl, aminocarbonyl, arylcarbonyl, heteroarylcarbonyl, cyano, carboxy, hydroxy, tetrazolyl, imidazole, oxazole, triazole, and â€”SOR wherein R is hydroxy, alkyl, aryl, alkoxy, aryloxy, cycloalkyl, heteroaryl, heteroarylalkyl, heteroaryloxy, heteroarylalkoxy and cycloheteroalkylalkoxy, Ar1 and Ar2 are identical or different, and represent optionally substituted aryl groups containing one or more rings optionally including one or more heteroatoms, selected from the group of O, N and S; wherein Ar1 and Ar2 do not comprise an optionally substituted indolyl substituent; and with the proviso that when X2 is CH2 or an isostere thereof, X1 is CO or an isostere thereof, and Ar2 is optionally substituted phenyl, Ar1 is other than benzimidazolyl or benzotriazolyl; wherein Y is selected from the group consisting of optionally substituted alkyl, alkoxy, cycloalkyl, cycloheteroalkyl , aryl, cycloheteroalkyl, heteroaryl, halogen, alkylaminocarbonyl, arlyaminocarbonyl, heteroarylaminocarbonyl, acyl, carboxy, hydroxy, aminocarbonyl, arylcarbonyl, heteroarylcarbonyl, cyano, amino, and alkylamino, wherein n is an integer from 0-4, and wherein m is an integer from 0-4 and 1 is an integer from 0-3.