Patent ID: 6451820
Filing Date: 2002-09-17
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein:R1 is pyridyl optionally substituted with halogen, C1-4 alkyl, C2-4 alkenyl, CN, Me2N, CO2Me, OMe, aryl, or R4; R2 is halogen, Me, Et, CF3, CN, cyclopropyl, vinyl, SMe, OMe, or aryl optionally substituted with halogen, C1-4 alkyl, CN, alkoxy, or Me2N, L is â€”NHC(O)â€”, â€”NHâ€”, â€”NHC(O)NH, or â€”NHCH(R5)â€”, wherein R5 is H, C1-4 alkyl, or CN; and R3 is C1-4 alkyl; C1-4 alkyloxyalkyl; C1-4 alkylthioalkyl; cyclohexyl, cyclopentyl, indanyl, indolyl, phenyl, thienyl, naphthyl, isoxazolyl, or pyridyl optionally substituted with one or more halogen, â€”CN, â€”NO2, SO2NH2, or R6, wherein R6 is C1-4 alkyl, C2-4 alkenyl, C1-6 alkyloxyalkyl, C1-6 alkylthioalkyl, or C2-6 alkynyl, and R6 is optionally substituted with OH, CN, â€”COO-lower alkyl, â€”CONH-lower alkyl, â€”CON(lower alkyl)2, dialkylamio, or CO2R6; â€”N(R6)2; â€”NH(R6); â€”C(O)R6; â€”OR6; S(O)nR6, wherein n is 0, 1, or 2; â€”SO2NHR6; or â€”SO2N(R6)2; and R4 is C1-4 alkyl or C2-4 alkenyl optionally substituted with carbocyclyl, or a pharnaceutically acceptable derivative thereof.