Patent ID: 6083943
Filing Date: 2000-07-04
Classification: A61K,C07D

Abstract:
A compound of the chemical formula (I) and its pharmaceutically acceptable salt: ##STR13## wherein Y is C.sub.3 alkylene;Z is a valence bond or C.sub.1 -C.sub.6 alkylene;R.sup.1 is phenyl, biphenyl, indanyl, naphthyl, thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, tetrazolyl, quinolyl, phenyl C.sub.1 -C.sub.6 alkyl- or benzhydryl, wherein each of the ring moieties may optionally be substituted by one or more substituents independently selected from halogen, C.sub.1 -C.sub.6 alkyl, halosubstituted C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy and halosubstituted C.sub.1 -C.sub.6 alkoxy;R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.3 is hydrogen, hydroxy, cyano, amino or carboxy; andR.sup.4 represents a group of the formula (II) or (III) ##STR14## wherein X.sup.1, X.sup.2 and X.sup.3 are each halo, hydrogen, nitro, C.sub.1 -C.sub.6 alkyl, halosubstituted C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halosubstituted C.sub.1 -C.sub.6 alkoxy, hydroxy, amino, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulfinyl or C.sub.1 -C.sub.6 alkylsulfonyl;Q.sup.1 and Q.sup.2 are each H.sub.2, oxygen or sulfur;A is valence bond, methylene, oxygen, sulfur or NH;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1 -C.sub.6 alkyl; andR.sup.7 is hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, halosubstituted C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy;provided that when Z is a valence bond, R.sub.3 must be hydrogen.