Patent ID: 6699866
Filing Date: 2004-03-02
Classification: C07D

Abstract:
A compound represented by A: whereinm is 0, 1, 2, or 3; n is 0, 1, 2, or 3; p is 1, 2, or 3; W represents CH2 or O; X represents S or O; Y represents CRâ€²; Z represents N(R5); Râ€² represents H, alkyl, or halogen; R1 represents H or alkyl; R2 represents aryl; R3 represents independently for each occurrence H, alkyl, alkoxyl, or alkylamino; R4 represents H or alkyl; R5 represents H or alkyl; R3 and R4 may be connected through a covalent bond, wherein R3 and R4 together with N(R5) represents pyrrolidine; and R4 and R5 may be connected through a covalent bond; wherein â€”N(R4)(R5) represents pyrrolidine, piperidine, piperazine, 4-morpholinyl, or 4-alkyl-1,4-piperazin-1-yl; and the stereochemical configuration at a stereocenter in a compound represented by A is R, S, or a mixture thereof.