Patent ID: 7655233
Filing Date: 2010-02-02
Classification: A61L,A61P,C07K,C12N

Abstract:
1. A method of virus inactivation in a post-manufacture immunoglobulin solution comprising: reducing the potential virus load of the immunoglobulin solution, adjusting the protein concentration of the immunoglobulin solution to equal or less than 6.0% w/v, adjusting the pH of the immunoglobulin solution to 6.3-6.4, contacting the immunoglobulin solution with 0.03% to 0.06% w/v of a di- or tri-alkyl phosphate solvent and 0.1% to less than 0.2% w/v of a non-ionic detergent for about 1 minute to about 1 hour at a temperature of 15-25° C.