Patent ID: 7368236
Filing Date: 2008-05-06
Classification: A61K,B82Y,C07H,C07K,C12N,C12Q,C40B,F02B,G01N

Abstract:
1. A method for modifying a nucleic acid ligand for a given target so that the modified ligand has at least one of the following improved properties: decreased size; improved stability; improved binding to the target; modification of biological activity of the target; resistance to clearance; wherein said modifying comprises adding, removing or substituting nucleotide residues, wherein said residues may be chemically modified, and/or chemically modifying said nucleic acid ligand based on: (a) determining which nucleotides are crucial to the interaction with the target molecule; (b) chemical modification experiments; or (c) determining the structural conformation of said nucleic acid ligand; and (d) modifying said ligand based on said determinations made in steps a) through c).