Patent ID: 6087351
Filing Date: 2000-07-11
Classification: A61K,A61P,Y10S

Abstract:
An in vivo method of reducing or depleting adenosine in a subject's tissue (s), comprising administering to a subject in need of treatment an amount of an agent effective to reduce or deplete adenosine levels in a subject's tissue (s); the agent being selected from the group consisting of a dehydrepiandrosterone of the chemical formula ##STR6## wherein the broken line represents a single or a double bond;R is hydrogen or a halogen;the H at position 5 is present in the alpha or beta configuration or the compound of formula I comprises a racemic mixture of both configurations; andR.sup.1 is hydrogen or SO.sub.2 OM, wherein M is selected from the group consisting of H, Na, sulphatide ##STR7## and phosphatide ##STR8## wherein R.sup.2 and R.sup.3, which may be the same or different, are straight or branched (C.sub.1 -C.sub.14) alkyl or glucuronide ##STR9## and pharmaceutically acceptable salts thereof.