Patent ID: 6462194
Filing Date: 2002-10-08
Classification: C07D,C07F

Abstract:
A process for the preparation of a compound of the formula: wherein E is a carboxy-protecting group and R1 and R2 are independently selected from loweralkyl, alkoxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, haloalkyl, haloalkoxyalkyl, alkoxyalkoxyalkyl, thioalkoxyalkoxyalkyl, cycloalkyl, cycloalkylalkyl, aminocarbonylalkyl, alkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, aminocarbonylalkenyl, alkylaminocarbonylalkenyl, dialkylaminocarbonylalkenyl, aryl, arylalkyl, aryloxyalkyl, arylalkoxyalkyl, (N-alkanoyl-N-alkyl)aminoakyl, alkylsulfonylamidoalkyl, heterocyclic and (heterocyclic)alkyl; or a salt thereof, comprisinga) reacting a compound of the formula: with hydrogen and Raney nickel or a platinum catalyst to provide a mixture comprising dihydropyrroles of the formula: b) reacting the product of step a) and an acid or a mixture of acids to provide a compound of the formula c) reacting the product of step b) and a base.