Patent ID: 7416897
Filing Date: 2008-08-26
Classification: B01J,C40B,G01N,Y10T

Abstract:
1. A method for high-throughput screening assay sample preparation and testing for identification of binding between target compounds and library compounds, for use with a device measuring the enthalpy of reaction for such binding, comprising: introducing not less than one selected library compound solution to a first solvent solution on the device such that they mix to form not less than one library compound/solvent solution; introducing not less than one target compound/second solvent solution on the device; establishing thermal equilibrium of the device; merging said not less than one library compound/solvent solution with said target compound/solvent solution at not less than one first location on the device; merging said not less than one library compound/solvent solution with a third solvent solution at not less than one second location on the device; detecting a first heat of reaction for said merged library compound/solvent solution and said target compound/solvent solution; detecting a second heat of reaction for said merged library compound/solvent solution with said third solvent solution; comparing said first and second heats of reaction; and detecting a binding operation has occurred between said merged library compound/solvent solution and said target compound/solvent solution, when the comparing step finds the first heat of reaction is greater than the second heat of reaction.