Patent ID: 7687469
Filing Date: 2010-03-30
Classification: A61P,C07H

Abstract:
1. A glucopyranosyl-substituted benzene derivative selected from among: (1) 1-Methyl-2-(4-cyclopentyloxy-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (2) 1-Methyl-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene, (3) 1-Methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene, (4) 1-Methyl-2-(4-cyclohexyloxy-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (5) 1-Chloro-2-[4-(1-tert-butyloxycarbonylpiperidin-4-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene, (6) 1-Chloro-2-[4-(piperdin-4-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene, (7) 1-Methoxy-2-(β-D-glucopyranos-1-yl)-4-(4-ethynyl-benzyl)-benzene, (8) 1-Chloro-2-(4-methoxymethylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (9) 1-Chloro-2-(4-hydroxymethylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (10) 1-Chloro-2-(4-hydroxyethylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (11) 1-Ethynyl-2-(4-methoxy-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (12) 1-Methyl-2-(4-butyn-1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (13) 1-Chloro-2-(4-propyn-1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (14) 1-Methyl-2-(4-propyn-1-yl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (15) 1-Isopropyl-2-(4-ethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, (16) 1-Chloro-2-(4-isopropylethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, or a derivative thereof wherein one or more hydroxyl groups of the β-D-glucopyranosyl group are acylated with groups selected from (C 1-18 -alkyl)carbonyl, (C 1-18 -alkyl)oxycarbonyl, phenylcarbonyl and phenyl-(C 1-3 -alkyl)-carbonyl, or a pharmaceutically acceptable salt thereof; including the tautomers, the stereoisomers thereof or the mixtures thereof, and salts thereof.