Patent ID: 6730784
Filing Date: 2004-05-04
Classification: C07C,C07D

Abstract:
A compound represented by the following formula or a salt thereof: whereinR2 is lower alkyl which is substituted by hydroxy, a nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring, cycloalkyl, cycloalkenyl, adamantyl, an aromatic group, phthalimido, guanidino which can be substituted by lower alkylsulfonyl or aromatic sulfonyl, RAâ€”COâ€”, RBâ€”Oâ€”, RCâ€”Sâ€”, RDâ€”COSâ€”, REâ€”OCOâ€”, RFâ€”N(RG)â€”, RHâ€”N(RJ)COâ€”, RKâ€”CONHâ€” or â€”CONHOH; R3 and R4, being the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl or an aromatic group; when R4 is lower alkyl, a terminal carbon of the lower alkyl can join with a carbon to which the alkyl is bonded to form a cycloalkyl ring; R5 and R6, being the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl or an aromatic group, or R5 and R6 join with each other to form a nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring, and the heterocyclic ring is unsubstituted or substituted by lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, an aromatic group or RAâ€”COâ€”; R7 is hydrogen, lower alkyl, cycloalkyl, hydroxy, mercapto, phenyl, â€”RBâ€”Oâ€”, RCâ€”Sâ€”, RDâ€”COSâ€”, REâ€”OCOâ€”, RFâ€”N(RG)â€” or â€”CONHOH; A1 is lower alkylene; A2 is lower alkylene; each lower alkyl defined above can be substituted by hydroxy, a nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring, cycloalkyl, cycloalkenyl, adamantyl, an aromatic group, phthalimido, guanidino which can be substituted by lower alkylsulfonyl or aromatic sulfonyl, RAâ€”COâ€”, RBâ€”Oâ€”, RCâ€”Sâ€”, RDâ€”COSâ€”, REâ€”OCOâ€”, RFâ€”N(RG)â€”, RHâ€”N(RJ)COâ€”, RKâ€”COHNâ€” or â€”CONHOH, except that when R7 is lower alkyl, the lower alkyl is not substituted by RKâ€”COHNâ€”; each lower alkenyl defined above is unsubstituted or substituted by hydroxy, lower alkyl, lower alkoxy, cycloalkyl, cycloalkenyl or an aromatic group; each cycloalkyl defined above is unsubstituted or substituted by lower alkyl, hydroxy, oxo or REâ€”OCOâ€”; each aromatic group defined above is unsubstituted or substituted by lower alkyl, hydroxy, lower alkoxy, phenyl-lower alkoxy, lower alkanoyloxy, halogen, nitro, an aromatic group, lower alkylsulfonyl, aromatic sulfonyl, REâ€”OCOâ€”, RFâ€”N(RG)â€” or RKâ€”CONHâ€”; the nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring defined above is unsubstituted or substituted by lower alkyl, cycloalkyl, an aromatic group or RAâ€”COâ€”, and the lower alkyl is unsubstituted or substituted by hydroxy, cycloalkyl, cycloalkenyl, an aromatic group, RAâ€”COâ€”, RBâ€”Oâ€”, REâ€”OCOâ€” or RFâ€”N(RG)â€”; and RA is lower alkyl, halogen-lower alkyl, an aromatic group, lower alkoxy, aromatic-lower alkoxy or RFâ€”N(RG)â€”; RB is lower alkyl or an aromatic group; RC is lower alkyl or an aromatic group; RD is lower alkyl or an aromatic group; RE is hydrogen, lower alkyl or an aromatic group; RF and RG, being the same or different, are hydrogen, lower alkyl, cycloalkyl or an aromatic group; RH and RJ, being the same or different, are hydrogen, lower alkyl, cycloalkyl, or an aromatic group; RK is lower alkyl, lower alkoxy or an aromatic group.