Patent ID: 6028076
Filing Date: 2000-02-22
Classification: A61P,C07D

Abstract:
A purine derivative represented by the following formula (Ia): ##STR15## wherein R.sup.2 is a hydrocarbon group containing at most 14 carbon atoms; any --CH.sub.2 -- group in said hydrocarbon group may be replaced with a carbonyl group, a sulfonyl group --O-- or --S-- when said --CH.sub.2 -- group is not directly attached to the purine ring or is in --CH.sub.3 group not directly attached to the purine ring: any .dbd.CH.sub.2 group may be replaced with .dbd.O or .dbd.S; C--H group in said hydrocarbon group may be replaced with N, a C-halogen group or a C--CN group when said C--H group is in --CH.sub.2 -- group not directly attached to the purine ring, in --CH.sub.3 group not directly attached to the purine ring, in >CH-- group not directly attached to the purine ring, in .dbd.CH-- group not directly attached to the purine ring or in .dbd.CH.sub.2 group;R.sup.6 is an amino group;R.sup.8 is a hydroxyl group, a mercapto group, a group of the formula:R.sup.10 --CO.sub.2 --wherein R.sup.10 is a hydrogen atom or a hydrocarbon group containing at most 17 carbon atoms,or an oxycarbonyloxy group substituted with a hydrocarbon group containing at most 19 carbon atoms;R.sup.9 is a hydrocarbon group containing at most 14 carbon atoms; any --CH.sub.2 -- group in said R.sup.9 may be replaced with a carbonyl group, a sulfonyl group, --O-- or --S-- when said --CH.sub.2 -- group is not directly attached to the purine ring or is in --CH.sub.3 group not directly attached to the purine ring; any .dbd.CH.sub.2 group may be replaced with .dbd.O or .dbd.S; C--H group in said R.sup.9 may be replaced with a C-halogen group or a C--CN group when said C--H group is in --CH.sub.2 -- group not directly attached to the purine ring, in --CH.sub.3 group not directly attached to the purine ring, in >CH-- group not directly attached to the purine ring, in .dbd.CH-- group not directly attached to the purine ring, in .dbd.CH.sub.2 group or in .tbd.CH group;or its tautomer or pharmaceutically acceptable salts thereof.