Patent ID: 8569494
Filing Date: 2013-10-29
Classification: A61P,C07D

Abstract:
1. A method of preparing a compound of formula (I), the method comprising contacting a compound of formula (III) with R X is halogen, B(OR Y is halogen, triflate, B(OR a) when X is halogen, then Y is B(OR b) when Y is halogen or triflate, then X is B(OR wherein each R R R R or R provided the compound is not 6-(4-hydroxyphenyl)-4-(3-methoxybenzyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, 6-(4-(1H-1,2,4-triazol-5-yl)phenyl)-3-(cyclohexylmethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, or (R)-6-(4-(1H-1,2,4-triazol-5-yl)phenyl)-3-(cyclohexylmethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.