Patent ID: 6784310
Filing Date: 2004-08-31
Classification: A61P,C07D

Abstract:
A method for crystallizing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxylic anhydridecomprising mixing a solution of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxylic anhydride in a good solvent with an aliphatic hydrocarbon solvent to crystallize said N-carboxylic anhydride, the solution of said N-carboxylic anhydride in the good solvent being added to the aliphatic hydrocarbon solvent to thereby effect crystallization while inhibiting an oil formation and scaling of said N-carboxylic anhydride wherein the good solvent is a halogenated hydrocarbon, an ether, a nitrile, an ester, a ketone or a mixed solvent thereof.