Patent ID: 7807463
Filing Date: 2010-10-05
Classification: A61K,A61P,C07K

Abstract:
1. A method for providing a donor mammal tissue or organ resistant to complement-dependent cytotoxicity mediated by preformed antibodies reactive with donor antigen in a sensitized recipient mammal of a species other than the donor mammal, comprising: infusing a non-human pre-immune fetal donor mammal at least one time with sub-lethal levels of bone marrow; allowing prolonged exposure to the bone marrow; harvesting a tissue or organ of the donor mammal; and determining that the tissue or organ of the donor mammal is resistant to complement-dependent cytotoxicity mediated by preformed antibodies of the sensitized recipient mammal reactive with donor antigen; wherein the method does not include administering an accommodation-inducing factor other than the bone marrow.