Patent ID: 8044089
Filing Date: 2011-10-25
Classification: A61P,C07D

Abstract:
1. A method of inhibiting translation initiation in a cell comprising contacting the cell with a compound of formula III, formula IV, formula VI, or formula VIII wherein the compound of formula III is: wherein X is oxygen, NH or CH R is 3′-CH 3′-O(CH 2 ) 4 NH 2 , 3′-CF 3 , 3′-CH 3 , 3′-n-heptyl, 3′-n-nonyl, 3′-i-Bu, 3′-i-propyl, 3′-n-propyl, 3′-n-octyl, 3′-Et, 3′-n-pentyl, 3′-n-Bu, 3′-n-hexyl, 3′-n-cyclopentyl, 3′-n-cyclohexyl, 4-NHSO 2 (4-tBu)Ph or 3′-NHSO 2 (4-tBu)Ph; the compound of formula IV is: wherein R is 4-F, 4-O(CH the compound of formula VI is: wherein R R the compound of formula VIII is: wherein R R R