Patent ID: 6133282
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR20## or a pharmaceutically acceptable salt thereof wherein:Ar is phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 4- or 5-pyrimidinyl, each of which is monosubstituted, or optionally di- or trisubstituted with halogen, hydroxy, lower alkyl, or lower alkoxy, provided that at least one of the ortho positions of Ar is substituted;R.sub.7 is hydrogen or alkyl;R.sub.1 and R.sub.2 taken together represent --(CH.sub.2).sub.n --A--(CH.sub.2).sub.m -- where n is 2, 3 or 4, A is methylene, oxygen, sulfur or NR.sub.6, wherein R.sub.6 is hydrogen or lower alkyl, and m is 0, 1 or 2; orR.sub.3 and R.sub.4 are not both hydrogen and independently representhydrogen, lower alkyl, phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl or 2-, 4-, or 5-pyrmidinyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, lower alkyl, or lower alkoxy,phenylalkyl, 2-, 3-, or 4-pyridylalkyl, 2- or 3-thienylalkyl, or 2-, 4-, or 5- pyrimidinylalkyl, where each alkyl is lower alkyl,cycloalkyl having 3-8 carbon atoms, cycloalkyl lower alkyl, 2-hydroxyethyl or 3-hydroxypropyl, each of which is optionally mono or disubstituted with lower alkyl; orR.sub.3 and R.sub.4 taken together represent --(CH.sub.2).sub.n --G--(CH.sub.2).sub.m --where n is 2, or 3;m is 1, 2, or 3; andG is methylene, 1,2 phenylene, oxygen, sulfur or NR.sub.6,wherein R.sub.6 is lower alkyl, phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl or 2-, 4-, or 5-pyrimidinyl, orR.sub.6 is phenylalkyl, 2-, 3-, or 4-pyridylalkyl, 2- or 3-thienylalkyl, or 2-, 4-, or 5-pyrimidinylalkyl where each alkyl is lower alkyl; andR.sub.5 is hydrogen, halogen, lower alkyl, lower alkoxy, or thioalkoxy.