Patent ID: 6583135
Filing Date: 2003-06-24
Classification: A61P,C07D

Abstract:
A compound of formula (IV): whereineach R2, independently, is selected from the group consisting of C1-8alkyl, and OH; R3 is hydrogen, C1-8alkyl, Het, R7C(&boxH;O)â€”, R7OC(&boxH;O)â€”, R5R6NC(&boxH;O)â€”, R7C(&boxH;S)â€”, R7SC(&boxH;O)â€”, R5R6NC(&boxH;S)â€”, R7SO2â€”, R5R6NSO2â€”, R7S(&boxH;O)â€”, R5R6NS(&boxH;O)â€”, RcC1-8hydrocarbylene-, or RcC1-8hydrocarbyleneC(&boxH;O)â€”; each R4, independently, is selected from the group consisting of Ar, C1-8alkyl, ArOâ€”, C1-8alkoxy, Het, halo, OH, CN, NO2, CF3, CF3O, NRaRb, N&boxH;CRaRb, R7S, C1-8hydrocarbyleneAr, and C1-8hydrocarbyleneORa; each R5 and R6 is independently hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, haloC1-8alkyl, C3-8cycloalkenyl, Ar, or â€”C1-8hydrocarbyleneAr; or R5 and R6 together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each R7 is independently hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, haloC1-8alkyl, C3-8cycloalkenyl, Ar, or â€”C1-8hydrocarbyleneAr; Ra and Rb, independently, are selected from the group consisting of hydrogen, C1-8alkyl, Ar, C1-3hydrocarbyleneAr, SO2Ar, SO2C1-4alkyl, (C3-8cycloalkyl)C1-8alkylene, and Het; Rc is Ar, Het, R7CO2â€”, R7C(&boxH;O)â€”, R7OC(&boxH;O)â€”, R7Oâ€”, R7C1-8alkyleneOâ€”, R7Sâ€”, R7C(&boxH;S)â€”, R7S(&boxH;O)â€”, R7S(&boxH;O)2â€”, R7SC(&boxH;O)â€”, R7C(&boxH;O)N(R7)â€”, R7C(&boxH;S)N(R7)â€”, R5R6Nâ€”, R5R6NC(&boxH;O)â€”, R5R6NC(&boxH;S)â€”, R5R6NS(&boxH;O)â€”, R5R6NSO2â€”, R7S(&boxH;O)N(R7)â€”, R7SO2N(R7)â€”, or R7N(R7)C(&boxH;O) N(R7)â€”; each Ar is independently aryl or heteroaryl; q is 0, 1, 2, 3, 4, 5, 6, 7, or 8; wherein any Ar of R4, R7, Ra and Rb, and optionally substituted with one or more substituents independently selected from halo, CN, NO2, ORe, methylenedioxy, ethylenedioxy, CF3, OCF3, SRe, SO2Re, NRfRg, CONRfRg, CORe, Re, and C1-8hydrocarbyleneRd; each Rd is independently hydroxy, C1-8alkoxy, cyano, SRh, or C(&boxH;O)Rh; each Re is independently selected from the group consisting of hydrogen, C1-8alkyl, Ar, C1-3hydrocarbyleneAr, SO2Ar, SO2C1-4 alkyl, (C3-8cycloalkyl)C1-8alkylene, and Het; wherein any Ar of Re is optionally substituted with one or more substituents independently selected from halo, CN, NO2, ORd, methylenedioxy, ethylenedioxy, CF3, OCF3, SRf, SO2Rf, NRfRg, CONRfRg, CORf, Rf, and C1-8hydrocarbyleneRd; each Rf and Rg, is independently selected from the group consisting of hydrogen, C1-8alkyl, Ar, C1-3hydrocarbyleneAr, SO2Ar, SO2C1-4 alkyl, (C3-8cycloalkyl)C1-8alkylene, and Het; each Rh is independently hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, haloC1-8alkyl, C3-8cycloalkenyl, phenyl, or â€”C1-8hydrocarbylene(phenyl); and each Het is selected from the group consisting of 1,3-dihydrobenzofuran, 1,3-dioxolane, 1,4-dioxane, 1,4-dithiane, 2H-pyran, 2-pyrazoline, 4H-pyran, chromanyl, imidazolidinyl, imidazolinyl, indolinyl, isochromanyl, isoindolinyl, morpholine, piperazinyl, piperidine, piperidyl, pyrazolidine, pyrazolidinyl, pyrazolinyl, pyrrolidine, pyrroline, quinuclidine, and thiomorpholino; and wherein p is 0, 1, 2, or 3; or a pharmaceutically acceptable salt thereof.