Patent ID: 6921772
Filing Date: 2005-07-26
Classification: A61K,A61P

Abstract:
1. A method for treating lymphoma in a patient, comprising administering to said patient a therapeutically effective amount of an indole or carbazole derivative of the formula: in which R 1 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, alkoxyloweralkyl, lower cycloalkyl, phenyl, benzyl and 2-thienyl; R 2 and R 3 are the same or different and are each selected from the group consisting of hydrogen and lower alkyl; R 4 and R 5 are the same or different and are each selected from the group consisting of hydrogen, lower alkyl, —NH 2 , —NHCHO, —NHCONH 2 , ═NW, oxo, —OH and —OCH3, wherein W is hydroxy, alkoxy, aryloxy, carboxyalkyloxy, arylamino or alkylsulfonylamino; R 6 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trifluoromethyl, hydroxy, lower alkoxy, trifluoroloweralkoxy, benzyloxy, araloxy, lower alkanoyloxy, acyl, amino, nitro, cyano, alkylimido, halo, mercapto, loweralkylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido and sulfamoyl; R 7 is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl; X is selected from the group consisting of carbon, oxy and thio; Y is selected from the group consisting of carbonyl, in which each of R 8 , R 9 , R 10 , R 11 , R 12 and R 13 is hydrogen or lower alkyl; and Z is selected from the group consisting of hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino and phenylamino, or a pharmaceutically acceptable salt thereof.