Patent ID: 7307085
Filing Date: 2007-12-11
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; n is 0 or 1; r is 0 or 1; s is 0 or 1; u is 2, 3, 4or 5; v is 1; a dashed line represents an optional double bond, provided that one and only one double bond is present in the ring; X is selected from: —(CR Y is selected from: —CR Z is selected from: —C(═O)—; R said aryl, cycloalkyl, aralkyl and heterocyclyl is optionally substituted with one or more substituents selected from R 10 ; R said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, aralkyl and heterocyclyl is optionally substituted with one or more substituents selected from R 10 ; or R R said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, alkylene and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ; R said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 11 , or R R said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl, optionally substituted with one to three substituents selected from R 14 ; R b is H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) 2 R a , optionally substituted with one to three substituents selected from R 14 ; R c and R c′ are independently selected from: H, (C 1 -C 6 )alkyl, aryl, heterocyclyl and (C 3 -C 6 )cycloalkyl, optionally substituted with one, two or three substituents selected from R 10 , or R c and R c′ can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one, two or three substituents selected from R 11 ; R d and R d′ are independently selected from: (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy and NR b 2 , or R d and R d′ can be taken together with the phosphorous to which they are attached to form a monocyclic heterocycle with 5-7 members the ring and optionally containing, in addition to the phosphorous, one or two additional heteroatoms selected from NR e , O and S, said monocyclic heterocycle optionally substituted with one, two or three substituents selected from R 11 ; and R e is selected from: H and (C 1 -C 6 )alkyl.