Patent ID: 8748195
Filing Date: 2014-06-10
Classification: G01N

Abstract:
1. An in vitro method for diagnosis and/or monitoring of the presence of a urinary tract infection (UTI) in a subject who does not have renal dysfunction, and who has symptoms of and is suspected of having a UTI, or who was previously diagnosed as having a UTI, comprising (a) detecting and quantitating the concentration of procalcitonin (PCT) in a urine sample from the subject and in a plasma sample from the subject, wherein the detection and quantitation comprises a PCT detection assay wherein the sample is contacted with an antibody that specifically binds to PCT to form a detectable PCT: antibody complex, and detecting and quantitating the complex; (b) comparing the detected concentration of PCT in the subject's urine sample with the concentration of PCT in the subject's plasma sample, wherein a ratio between the PCT concentration in the urine sample and the PCT concentration in the plasma sample>1 is predictive of the presence of the UTI; and whereby the diagnosis or monitoring of the presence of the UTI is used to determine whether to prescribe a UTI treatment for the subject, when the subject being diagnosed or monitored is predicted to have or still have the UTI.