Patent ID: 9187730
Filing Date: 2015-11-17
Classification: A61K,A61P,C12N

Abstract:
1. An immunogenic composition comprising one or more strains of inactivated or live, attenuated Equine Rhinitis A Virus (ERAV), wherein: (a) said ERAV strain, prior to inactivation or attenuation, causes detectable respiratory disease in at least 50% of seronegative horses exposed to ERAV or ERBV, or grows in a Vero cell culture to 106 TCID50/mL or higher, or, when used as a vaccine in equines at a dose of 106 TCID50 or higher results in a serum titer of at least 1:112; and (b) said ERAV strain comprising a genomic sequence whose reverse transcript has a nucleotide sequence comprising SEQ ID NO: 2 or encodes a polyprotein with an amino acid sequence comprising SEQ ID NO: 3, said ERAV strain, prior to inactivation or attenuation, is active to infect and replicate in host cells.