Patent ID: 6429353
Filing Date: 2002-08-06
Classification: A01K,C12N

Abstract:
A method for generating a mouse model for human endometriosis comprising:a. eliminating endogenous progesterone from a severely compromised immune deficient (SCID) female mouse by a bilateral oophorectomy or by administration of an anti-progesterone agent; b. adding a micronized exogenous estrogen source to a xenograft of human normal endometrial tissue; c. implanting the xenograft into the intraperitoneal cavity of the mouse; d. adding an exogenous estrogen source to the mouse before and after implantation of the xenograft; and e. allowing the xenograft to grow and nimic the progression of human endometriosis tissue; wherein the oophorectomy or administration of the anti-progesterone agent is performed at least one week prior to the implanting of the xenograft into the intraperitoneal cavity of the mouse.