Patent ID: 7220730
Filing Date: 2007-05-22
Classification: A61K,C07H

Abstract:
1. A cancer-specific radiolabeled conjugate of the formula: wherein B* represents uracil substituted with a radionuclide; R represents H, OH, or O-L-DHT, L being a cleavable bifunctional linking moiety and DHT is 4-dihydrotestosterone which is bound through its hydroxyl substituent to said linking moiety; and R′ represents H or a group having the formula—PO(OR a )(OR b ), —PO(OR a )(ODHT) or —PO(ODHT) 2 , R a and R b being the same or different and representing H or lower alkyl having 1–8 carbon atoms and DHT is as previously defined, with the proviso that at least one of the R and R′ substituents comprises a DHT moiety.