Patent ID: 7985411
Filing Date: 2011-07-26
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A recombinant single-chain polypeptide comprising: a) a first domain comprising a binding element comprising a basic fibroblast growth factor peptide able to preferentially interact with a fibroblast growth factor receptor of a target cell under physiological conditions; b) a second domain comprising a translocation element comprising a Clostridial neurotoxin translocation domain able to facilitate the transfer of a Clostridial toxin light chain across a vesicular membrane; c) a third domain comprising a therapeutic element comprising a Clostridial neurotoxin light chain having biological activity when released into the cytoplasm of said target cell; and d) a fourth domain comprising a non-native Clostridial neurotoxin protease cleavage site.