Patent ID: 6294382
Filing Date: 2001-09-25
Classification: A61K,C07K,C12N,C12Q,Y02P

Abstract:
An antisense compound 8 to 30 nucleobases in length targeted to nucleotides 14 through 31 of a 5' untranslated region, nucleotides 27 through 46 of a start codon, nucleotides 63 through 80, nucleotides 120 through 137, nucleotides 203 through 220, nucleotides 283 through 300, nucleotides 339 through 356, nucleotides 482 through 499, nucleotides 822 through 839, nucleotides 907 through 924, nucleotides 1200 through 1217, nucleotides 1301 through 1318, nucleotides 1710 through 1727, nucleotides 1886 through 1903, nucleotides 2047 through 2064, nucleotides 2370 through 2387, nucleotides 2757 through 2774, nucleotides 2963 through 2980, nucleotides 3288 through 3305, nucleotides 3491 through 3508, nucleotides 3697 through 3714, nucleotides 4072 through 4089, nucleotides 4243 through 4260 of a coding region, nucleotides 4353 through 4383 of a stop codon, or nucleotides 4466 through 4483 of a 3' untranslated region of SEQ ID NO. 3 encoding human SRC-1, wherein said antisense compound specifically hybridizes with and inhibits the expression of human SRC-1 gene.