Patent ID: 8846699
Filing Date: 2014-09-30
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: N-[7-(1-acetyl-piperidin-4-ylmethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[1-(2,2,2-trifluoro-acetyl)-piperidin-4-ylmethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[1-(2-methanesulfonyl-acetyl)-piperidin-4-ylmethoxy]-quinazolin-6-yl}-acrylamide; 4-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxymethyl]piperidin-1-carboxylic acid amide; N-[7-(1-acryloyl-piperidin-4-ylmethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(pyridin-4-ylmethoxy)-quinazolin-6-yl]-acrylamide; N-[7-(1-acetyl-piperidin-4-ylmethoxy)-4-(2,3,4-trifluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(1-acetyl-piperidin-4-ylmethoxy)-4-(4-bromo-2,6-difluoro-phenylamino)-quinazolin-6-yl]-acrylamide; 4-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid propylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[1-(2-dimethylamino-acetyl)-piperidin-4-ylmethoxy]-quinazolin-6-yl}-acrylamide; 4-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid 1-butylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[3-(2-dimethylamino-acetylamino)-propoxy]-quinazolin-6-yl}-acrylamide; N-[7-(3-acetylamino-propoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[3-(2-methanesulfonyl-acetylamino)-propoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-[3-(3-ethyl-ureido)-propoxy]-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(3-methylamino-propoxy)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-dimethylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-[7-(4-acetylamino-butoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide, Cyclopropane carboxylic acid {2-[6-acrylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2,2-difluoro-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-ethyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-ureido-ethoxy)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl]-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-propionylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-quinazolin-6-yl]-acrylamide; N-[7-(2-amino-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-methylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-but-3-enyloxy-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-methoxy-ethoxy)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-methanesulfonylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-propyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-methyl-thioureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-ethyl-thioureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-isopropyl-ureido)-ethoxy]-quinazolin-6-yl}acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-sec-butyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-vinyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[7-[2-(3-allyl-ureido)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; Morpholine-4-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-[7-[2-(acetyl-methyl-amino)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-methoxy-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-hydroxy-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-methylsulfanyl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-methanesulfonyl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-isobutyrylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-2-methyl-acrylamide; But-2-enoic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-butylamide; Pent-2-enoic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; 4-dimethylamino-but-2-enoic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-t-butyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-oxo-propylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-(4-(4-bromo-2-fluoro-phenylamino)-7-{2-[2-(ethyl-methyl-amino)-acetylamino]-ethoxy}-quinazolin-6-yl)-acrylamide; N-[7-[2-(2-amino-acetylamino)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-diethylamino-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-methylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-dimethylamino-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[7-[2-(3-amino-propionylamino)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-carbamic acid methylester; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-methoxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[(2-diethylamino-ethylcarbamoyl)-methoxy]-quinazolin-6-yl}-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-4-dimethylamino-butylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-hydroxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(2,4-difluorophenylamino)-7-{2-[2-(dimethylamino)-acetylamino]-ethoxy}-quinazolin-6-yl]-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-malonic acid ethylester; {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-oxalamic acid ethylester; {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-oxalamic acid; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-methoxyimino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-dimethylamino-2-methyl-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-3-dimethylamino-butylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-2-methyl-acrylamide; Propionic acid [7-(2-acetylamino-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-amide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-N-methyl-acrylamide; N-4-(4-bromo-3-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl-acrylamide; N-[7-(2-acetylamino-1-methyl-ethoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-propoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; (R)—N—F-(2-acetylamino-propoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; (S)—N-[7-(2-acetylamino-propoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-propionylamino-propoxy)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-propyl-ureido)-propoxy]-quinazolin-6-yl}-acrylamide; N-[7-(2-acetylamino-butoxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(3-propionylamino-propoxy)-quinazolin-6-yl]-acrylamide; N-[7-(1-acetyl-pyrrolidin-3-yloxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(1-acetyl-piperidin-3-yloxy)-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(thiazol-2-ylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(2-oxo-oxazolidin-5-ylmethoxy)-quinazolin-6-yl]-acrylamide; Thiophene-2-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; Morpholine-4-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; Piperazine-1-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; 4-acetyl-piperazine-1-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl)-amide; 4-methyl-piperazine-1-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}amide; Pyrrolidine-2-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; 1-methyl-pyrrolidine-2-carboxylic acid (2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; 1H-pyrrole-2-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-piperidin-1-yl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-(4-(4-bromo-2-fluoro-phenylamino)-7-{2-[2-(4-methyl-piperazin-1-yl)-acetylamino]-ethoxy}-quinazolin-6-yl)-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-morpholin-4-yl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-piperidin-1-yl-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; 1-acetyl-pyrrolidine-2-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; 1-propionyl-pyrrolidine-2-carboxylic acid {2-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-amide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-pyrrolidin-1-yl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-2,5-dihydro-pyrrol-1-yl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4-bromo-2-fluoro-phenylamino)-7-(4,5-dihydro-oxazol-2-ylmethoxy)-quinazolin-6-yl]-acrylamide; N-[7-[2-(2-azetidin-1-yl-acetylamino)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-chloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-chloro-2-chloro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2-trifluoromethyl-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2-chloro-phenylamino)-quinazolin-6-yl]-acrylamide; N-{4-(4-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(3-chloro-2-fluoro-phenylamino)-7-{2-[2-(dimethylamino)-acetamido]-ethoxy}quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(2,3,4-trifluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2,5-difluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-2,6-difluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(2,4,5-trichloro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-2,6-difluorophenylamino)-7-{2-[2-(dimethylamino)-acetamido]-ethoxy}-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-2,3-difluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2,3-difluoro-phenylamino)-7-[2-(3-diethylamino-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2,3-difluoro-phenylamino)-7-[2-(3-piperidin-1-yl-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-2,3-difluoro-phenylamino)-quinazolin-7-oxy]-ethyl}-4-dimethylamino-butylamide; N-[7-(2-acetylamino-ethoxy)-4-(6-chloro-pyridin-3-ylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-chloro-2-fluoro-5-methoxy-phenylamino)-quinazolin-6-yl]-acrylamide; N-{7-(2-acetylamino-ethoxy)-4-[3-chloro-4-(pyridin-3-ylmethoxy)-phenylamino]-quinazolin-6-yl}-acrylamide; 5-[7-(2-acetylamino-ethoxy)-6-acryloylamino-quinazolin-4-ylamino]-2-bromo-4-fluoro-N-methoxy-benzamide; N-[7-(2-acetylamino-ethoxy)-4-(2,4-dichloro-5-methoxy-phenylamino)-quinazolin-6-yl]-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-5-chloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-5-chloro-2-fluoro-phenylamino)-7-(2-propionylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-5-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-dimethylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-propionylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-{4-(4,5-dichloro-2-fluoro-phenylamino)-7-[2-(2-methoxy-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4,5-dichloro-2-fluoro-phenylamino)-7-[2-(2-methanesulfonyl-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4,5-dichloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide; N-[4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-(2-propionylamino-ethoxy)-quinazolin-6-yl]-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-diethylamino-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-hydroxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-methoxy-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-piperidin-1-yl-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{2-[6-acryloylamino-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-4-dimethylamino-butylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-hydroxy-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-methoxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-diethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino-propoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-2-methyl-propoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(3-diethylamino-propionylamino)-propoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-3-methylbutoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-propoxy]-quinazolin-6-yl-acrylamide; (S)—N-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-propoxy]-quinazolin-6-yl-acrylamide; (R)—N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-propoxy]-quinazolin-6-yl-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-butoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-3-methoxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-3-hydroxy-propionylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; (S)—N-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-propoxyl-quinazolin-6-yl-acrylamide; (R)—N-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-propoxy]-quinazolin-6-yl-acrylamide; {2-[6-acryloylamino-4-(4-bromo-3-chloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethyl}-carbamic acid methylester; N-{4-(4-chloro-2,5-dimethoxy-phenylamino)-7-[2-(2-dimethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-2-fluoro-phenylamino)-7-[2-(2-diethylamino-acetylamino)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-ethyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-propyl-ureido)-ethoxy]-quinazolin-6-yl}-acrylamide; N-{4-(4-bromo-3-chloro-2-fluoro-phenylamino)-7-[2-(3-ethyl-thioureido)-ethoxy]-quinazolin-6-yl}-acrylamide; 4-[6-acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid ethylamide; N-[7-(2-acetylamino-ethoxy)-4-(4-chloro-2,5-dimethoxy-phenylamino)-quinazolin-6-yl]-acrylamide; and N-[7-[2-(2-amino-propionylamino)-ethoxy]-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide, or a pharmaceutically acceptable salt thereof.