Patent ID: 6297260
Filing Date: 2001-10-02
Classification: A61K,A61P,C07C,C07D,C07F

Abstract:
A compound of formula (I), formula (II), formula (III), formula (IV), or a pharmaceutically acceptable salt thereof:wherein the compound of formula (I) is: ##STR15##whereinR.sub.g is a hydrogen atom or a lower alkyl group;R.sub.h is: ##STR16## ##STR17## ##STR18## ##STR19## ##STR20## ##STR21## ##STR22##n is an integer of 0 or 1;X is:(i) --T--B.sub.l --W--B.sub.t --T--NO.sub.s ;(ii) --T--B.sub.l --L.sub.y --B.sub.x --T--NO.sub.s ;(iii) --T--B.sub.l --W--B.sub.t --W.sub.x --B.sub.k --T--NO.sub.s ;(iv) --T--B.sub.l --(C(R.sub.b)(R.sub.c)).sub.p --E.sub.x --T--NO.sub.s ;(v) --T--B.sub.l --G--B.sub.t --W.sub.z --B.sub.k --G.sub.x --B.sub.r --T--NO.sub.s ;(vi) --T--B.sub.l --J--E.sub.x --T--NO.sub.s ; or(vii) --T--B.sub.l --C(R.sub.c).dbd.N--E.sub.z --T--NO.sub.s ;whereins is an integer of 1 or 2;T at each occurrence is independently a covalent bond, a carbonyl, an oxygen, --S(O).sub.o -- or --N(R.sub.a)(R.sub.i)--;o is an integer from 0 to 2;R.sub.a is a lone pair of electrons, a hydrogen or an alkyl group;R.sub.i is a hydrogen, an alkyl group, an aryl group, an alkylcarboxylic acid group, an aryl carboxylic acid group, an alkylcarboxylic ester group, an arylcarboxylic ester group, an alkylcarboxamido, an arylcarboxamido, an alkylaryl, an alkylsulfinyl, an alkylsulfonyl, an arylsulfinyl, an arylsulfonyl, a sulfonamido, a carboxamido, a carboxylic ester group, an amino alkyl, an amino aryl, --CH.sub.2 --C(T--Q)(R.sub.e)(R.sub.f), or --(N.sub.2 O.sub.2.sup.-).sup.-.cndot.M.sup.+, wherein M.sup.+ is an organic or inorganic cation;L at each occurrence is independently --C(O)--, --C(S)--, --T--, a heterocyclic ring, an aryl group, an alkenyl group, an alkynyl group, an arylheterocyclic ring, or --(CH.sub.2 CH.sub.2 O).sub.q ;q is an integer from 1 to 5;B at each occurrence is independently an alkyl group, an aryl group, or --(C(R.sub.e)(R.sub.f)).sub.p --, a heterocyclic ring, an aryl heterocyclic ring, or --(CH.sub.2 CH.sub.2 O).sub.q ;p is an integer from 1 to 10;R.sub.e and R.sub.f are each independently a hydrogen, an alkyl, a cycloalkoxy, a halogen, a hydroxy, an hydroxyalkyl, an alkoxyalkyl, an arylheterocyclic ring, an alkylaryl, a cycloalkylalkyl, a heterocyclicalkyl, an alkoxy, a haloalkoxy, an amino, an alkylamino, a dialkylamino, an arylamino, a diarylamino, an alkylarylamino, an alkoxyhaloalkyl, a haloalkoxy, a sulfonic acid, an alkylsulfonic acid, an arylsulfonic acid, an arylalkoxy, an alkylthio, an arylthio, a cyano, an aminoalkyl, an aminoaryl, an alkoxy, an aryl, an arylalkyl, an alkylaryl, a carboxamido, a alkyl carboxamido, an aryl carboxamido, an amidyl, a carboxyl, a carbamoyl, an alkylcarboxylic acid, an arylcarboxylic acid, an ester, a carboxylic ester, an alkylcarboxylic ester, an arylcarboxylic ester, a haloalkoxy, a sulfonamido, an alkylsulfonamido, an arylsulfonamido, a urea, a nitro, --T--NO.sub.s, or (C(R.sub.e)(R.sub.f)).sub.k --T--NO.sub.s, or R.sub.e and R.sub.f taken together with the carbon atoms to which they are attached are a heterocyclic ring, a cycloalkyl group or a bridged cycloalkyl group;R.sub.b and R.sub.c are each independently a haloalkyl, an alkenyl group, an alkynyl group, a bridged cycloalkyl group, a heterocyclic ring, a cycloalkoxy, a halogen, a hydroxy, an hydroxyalkyl, an alkoxyalkyl, an arylheterocyclic ring, an alkylaryl, a cycloalkylalkyl, a heterocyclicalkyl, an alkoxy, a haloalkoxy, an amino, an alkylamino, a dialkylamino, an arylamino, a diarylamino, an alkylarylamino, an alkoxyhaloalkyl, a haloalkoxy, a sulfonic acid, an alkylsulfonic acid, an arylsulfonic acid, an arylalkoxy, an alkylthio, an arylthio, a cyano, an aminoalkyl, an aminoaryl, an alkoxy, an arylalkyl, an alkylaryl, a carboxamido, an alkyl carboxamido, an aryl carboxamido, an amidyl, a carboxyl, a carbamoyl, an alkylcarboxylic acid, an arylcarboxylic acid, an ester, a carboxylic ester, an alkylcarboxylic ester, an arylcarboxylic ester, a haloalkoxy, a sulfonamido, an alkylsulfonamido, an arylsulfonamido, a urea, a nitro, --T--NO.sub.s, or (C(R.sub.e)(R.sub.f)).sub.k --T--NO.sub.s, or R.sub.b and R.sub.e taken together with the carbon atoms to which they are attached are a carbonyl, a methanthial, a heterocyclic ring, a cycloalkyl group or a bridged cycloalkyl group;G is a covalent bond, --T--C(O)--, --C(O)--T-- or T;J is a carbonyl, a phosphoryl or a silyl;k, l, t and z are each independently an integer from 1 to 3;y is an integer from 1 to 3;x and r are each independently an integer from 0 to 3;E at each occurrence is independently --C(O)--, --C(S)--, --T--, --(C(R.sub.e)(R.sub.f)).sub.p --, an alkyl group, an aryl group, a heterocyclic ring, arylheterocyclic ring, or --(CH.sub.2 CH.sub.2 O).sub.q ;W is oxygen, --S(O).sub.o --, --N(R.sub.a)(R.sub.i)--, carbonyl, or methanthial;with the proviso that when R.sub.i is --CH.sub.2 --C(T--NO.sub.s)(R.sub.e)(R.sub.f) or --(N.sub.2 O.sub.2.sup.-).sup.-.cndot.M.sup.+, or R.sub.b, R.sub.c, R.sub.e or R.sub.f are T--NO.sub.s or (C(R.sub.e)(R.sub.f)).sub.k --T--NO.sub.s, then the ""--T--NO.sub.s "" subgroup designated in X can be a hydrogen, an alkyl, an alkoxy, an alkoxyalkyl, an aminoalkyl, a hydroxy, a heterocyclic ring or an aryl group;wherein the compound of formula (II) is: ##STR23##whereinR.sub.k is: ##STR24## ##STR25## ##STR26##and X is as defined as herein;wherein the compound of formula (III) is: ##STR27##whereinX is as defined herein;R.sub.i at each occurrence is independently R.sub.i, wherein R.sub.i is as defined herein;Z is an aryl group; andA.sub.1, A.sub.2 and A.sub.3 comprise the other subunits of a 5- or 6-membered monocyclic aromatic ring and each of A.sub.1, A.sub.2 and A.sub.3 is independently:(1) C--R.sub.o, wherein R.sub.o at each occurrence is independently a hydrogen, an alkyl, an alkoxyalkyl, a halogen or a nitro group;(2) N--R.sub.p, wherein R.sub.p at each occurrence is independently a covalent bond to an adjacent ring atom in order to render the ring aromatic, a hydrogen, an alkyl, an arylalkyl, an aryl or a heteroaryl group;(3) a sulfur atom;(4) an oxygen atom; or(5) B.sub.a.dbd.B.sub.b, wherein B.sub.a and B.sub.b are each independently a nitrogen atom or C--R.sub.o wherein R.sub.o is as defined herein;wherein the compound of formula (IV) is: ##STR28##whereinR.sub.m is an alkyl group or an aryl group; and X, Z, A.sub.1, A.sub.2 and A.sub.3 are as defined herein.