Patent ID: 8912333
Filing Date: 2014-12-16
Classification: A61P,C07D

Abstract:
1. A process for the preparation of solid of pitavastatin tert-butyl ester, which comprises: a. reacting R-(-)-camphor sulfonic acid with tert-butyl-(3R,5S,6Z)-7-{2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl}-3,5-isopropylidenedioxy-6-heptenoate in a nitrile solvent and water; b. adding a mixture of water and a solvent selected from an ester solvent, a chlorinated solvent, an ether solvent or mixture thereof; c. concentrating the reaction mass; d. adding hydrocarbon solvent to the residual mass obtained in step (c); and e. isolating solid pitavastatin tert-butyl ester.