Patent ID: 7696309
Filing Date: 2010-04-13
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated mutant form of stromal cell derived factor-1 (SDF-1) peptide comprising a mutant SDF-1 (mSDF-1) or X p -mSDF-1, wherein: a) X is proteinogenic amino acid(s) or a protease protective organic group; b) p is any integer from 1 to 4; c) said mSDF-1 comprises the amino acid sequence of SEQ ID NO:53, wherein mSDF-1 maintains chemoattractant activity for T cells and is inactivated by matrix metalloproteinase-2 (MMP-2) at a rate that is less than one-half of the rate of inactivation of native SDF-1; and d) X