Patent ID: 7303926
Filing Date: 2007-12-04
Classification: A61K,A61P,B82Y,C09B,Y10S

Abstract:
1. A method of performing a phototherapeutic procedure comprising: (a) administering a photosensitizing mixture to a target tissue in an animal, the photosensitizing mixture comprising organic azides having the formula E-L-DYE-X—N DYE is an aromatic or a heteroaromatic radical derived from the group consisting of cyanines, indocyanines, phthalocyanines, rhodamines, phenoxazines, phenothiazines, phenoselenazines, fluoresceins, porphyrins, benzoporphyrins, squaraines, corrins, croconiums, azo dyes, methine dyes, and indolenium dyes; E is a hydrogen atom or is selected from the group consisting of somatostatin receptor binding molecules, ST receptor binding molecules, neurotensin receptor binding molecules, bombesin receptor binding molecules, cholecystekinin receptor binding molecules, steroid receptor binding molecules, and carbohydrate receptor binding molecules; L is selected from the group consisting of —(CH X is either a single bond or is selected from the group consisting of —(CH R R a to l independently range from 0 to 10; and (b) exposing the target tissues to light of wavelength between 300 and 950 nm with sufficient power and fluence rate to enable the organic azides to cause necrosis or apoptosis of the target tissue.