Patent ID: 6153624
Filing Date: 2000-11-28
Classification: A61K,A61P

Abstract:
A method of treating a disease in a mammal caused by over activation of NMDA receptor subtypes comprising administering to said mammal a compound of formula I ##STR11## wherein R.sup.1 and R.sup.2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, --CONH.sub.2 or --C(O)O-lower alkyl; or taken together are --O--CH.sub.2 --O--;R.sup.3 and R.sup.4 are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, --CONH.sub.2 or --SCH.sub.3 ; or taken together are --O--CH.sub.2 --O--;R.sup.5 is hydrogen or lower alkyl;X and Y are, independently from each other --CH(OH)--, --(CH.sub.2).sub.n --, --C(O)-- or --CH(lower alkoxy)-; andm and n are 1 or 2;or a pharmaceutically acceptable salt of said compound and a therapeutically acceptable carrier in an amount which is effective in treating diseases caused by over activation of NMDA receptor subtypes.