Patent ID: 8586097
Filing Date: 2013-11-19
Classification: A61K,A61P

Abstract:
1. A method of preparing a core-shell composite comprising a polymeric core component and a crosslinked polymeric shell component, the method comprising preparing a first phase comprising a polymeric core component and a shell polymer in a first liquid, the shell polymer being substantially dissolved in the first liquid, comprising preparing a second phase comprising a crosslinking agent in a second liquid, the second liquid being substantially immiscible with the first liquid, combining the first phase and the second phase to form a heterogeneous multiphase media, crosslinking the shell polymer with the crosslinking agent on a surface of the core component to form the core-shell composite in the multiphase media, and removing at least a portion of the first liquid from the heterogeneous multiphase media during crosslinking; wherein the core component comprises a cation exchange polymer and the shell polymer comprises a net positively charged crosslinked amine polymer comprising amine moieties and the core-shell particle has a size of 1 μm to 500 μm and a binding capacity for potassium of at least 1.5 mmol/g at a pH greater than 5.5.