Patent ID: 7081518
Filing Date: 2006-07-25
Classification: A61K,A61P,C07K

Abstract:
1. An isolated anti-mesothelin antibody comprising a variable heavy (“V H ”) chain and a variable light (“V L ”) chain, which V H and V L chains each have a first, a second and a third complementarity-determining region (“CDR”), wherein the first CDR (“CDR1”), the second CDR (“CDR2”), and third CDR (“CDR3”), respectively, of said heavy chain have the amino acid residue sequence shown for CDR1, CDR2, and CDR3, respectively, of the heavy chain shown in FIG. 1 , and wherein CDRs 1, 2 and 3 respectively, of said V L chain, have the amino acid residue sequence shown for CDR1, CDR2, and CDR3 respectively, of the light chain shown in FIG. 1 , provided that the sequence of amino acid residues in CDR3 of the V L chain differs from that shown in FIG. 1 by a substitution selected from G93K-Y94H (antibody SS1), S92G-G93F-Y94(antibody D8), S92G-G93S-Y94H (antibody C10), Y94H (antibody C5), G93A-Y94H (antibody D7), G93Q-Y94I (antibody B7), S92G-G93T-Y94N (antibody D9), S92G-G93D-Y94F (antibody C3), S92G-G93D-Y94H (antibody C4) and L96T, (antibody E4), said amino acid residues being numbered as in FIG. 3 .