Patent ID: 6180648
Filing Date: 2001-01-30
Classification: A61P,C07B,C07D

Abstract:
A compound of formula I: ##STR4##whereinY is NR.sup.6 ;R.sup.1 is --C(O)OR.sub.a, cyano, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.2 -C.sub.6)alkenyl, or (C.sub.2 -C.sub.6)alkynyl, wherein any instance of R.sub.1 which is (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.2 -C.sub.6)alkenyl, or (C.sub.2 -C.sub.6)alkynyl may optionally be substituted by 1, 2 or 3 Z, wherein each Z is independently chloro, bromo, iodo, nitro, cyano, (C.sub.2 -C.sub.6)acyloxy, C(O)OR.sub.b, C(O)NR.sub.c R.sub.d, or S(O).sub.n R.sub.g ; and R.sup.3 is phenyl, (C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, or (C.sub.6 -C.sub.10)arylcarbonyl, wherein any phenyl substituent is substituted with 1, 2, or 3 instances of Z, and any other (C.sub.6 -C.sub.10)aryl substituent may optionally be substituted on carbon by 1, 2 or 3 Z; orR.sup.1 is --CH.sub.2 --, or --CH.sub.2 CH.sub.2 --, wherein R.sup.1 is attached to a carbon at the ortho position of R.sup.3 ; and R.sup.3 is (C.sub.6 -C.sub.10)aryl;R.sup.2 is hydrogen or (C.sub.1 -C.sub.6)alkyl;R.sup.6 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, or S(0).sub.2 R.sub.h ;n is 0, 1 or 2;R.sub.a to R.sub.g are independently hydrogen or (C.sub.1 -C.sub.4)alkyl; andR.sub.h is H, (C.sub.1 -C.sub.4)alkyl, or phenyl; or a pharmaceutically acceptable salt thereof.