Patent ID: 7723073
Filing Date: 2010-05-25
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A composition comprising isolated nucleic acid sequences comprising (a) a coding sequence for a light chain of an anti-VLA-1 antibody or antigen binding fragment thereof, and (b) a coding sequence for a heavy chain of an anti-VLA-1 antibody or antigen binding fragment thereof, wherein the light chain and the heavy chain form an antibody or antigen binding fragment thereof that binds VLA-1, and wherein the light chain and heavy chain are selected from one of the light chain and heavy chain pairs of the group consisting of: (i) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, which has the sequence of SEQ ID NO:3, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, which has the sequence of SEQ ID NO:4; (ii) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:49, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:42; (iii) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:51, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:44; (iv) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:54, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:42; (v) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:58, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:68; (vi) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:70, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:68; (vii) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:66, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:42; (ix) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:54, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:68; (x) a light chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose light chain variable domain has the sequence of SEQ ID NO:47, and a heavy chain of an anti-VLA-1 antibody, or antigen-binding fragment thereof, whose heavy chain variable domain has the sequence of SEQ ID NO:68; (xi) a light chain of an antibody produced by hybridoma mAQC2 (ATCC accession number PTA3273), and a heavy chain of an antibody produced by hybridoma mAQC2 (ATCC accession number PTA3273); (xii) a light chain of an antibody produced by cell line hAQC2 (ATCC accession number PTA3275), and a heavy chain of an antibody produced by cell line hAQC2 (ATCC accession number PTA3275); (xiii) a light chain of an antibody produced by cell line haAOC2 (ATCC accession number PTA3274), and a heavy chain of an antibody produced by cell line haAQC2 (ATCC accession number PTA3274); and, (xiv) a light chain of an antibody produced by cell line hsAOC2 (ATCC accession number PTA3356), and a heavy chain of an antibody produced by cell line hsAQC2 (ATCC accession number PTA3356).