Patent ID: 8067555
Filing Date: 2011-11-29
Classification: A61K,C07H,C08B

Abstract:
1. A process for the preparation of a compound of formula (I) where R and R X and X′ are a —CH n and m, which can be the same or different, may vary from 1 to 40; the sum of n+m ranges from 6 to 40; the m:n ratio ranges from 10:2 to 1:1, the symbol indicates that the units marked m and n are statistically distributed along the polysaccharide chain and are not necessarily in sequence, comprising the following steps: a) N-desulphation by solvolytic hydrolysis of sulphamino residues n DMSO:H b) N-acylation of said totally or partially desulphated groups at position 2 of the glucosamine residues by treatment in alkaline aqueous solution (pH 8-9) with an acylating agent, to give totally or partially acylated groups at position 2 of the glucosamine residues; c) oxidation of the diols with sodium periodate, to yield the opening of the glycoside ring and the formation of two aldehyde groups per modified residue; and d) reduction of said aldehyde groups to primary alcohol.