Patent ID: 7091216
Filing Date: 2006-08-15
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: wherein: R wherein alkyl, alkenyl, and alkynyl are optionally substituted with one, two, or three substituents independently selected from R a , and cycloheteroalkyl, aryl and heteroaryl are optionally substituted with one, two, or three substituents independently selected from R b ; R wherein alkyl, alkenyl, and alkynyl are optionally substituted with one, two, or three substituents independently selected from R a ; and aryl and heteroaryl are optionally substituted with one, two, or three substituents independently selected from R b , and cycloheteroalkyl is optionally substituted with one, two, three or four substituents independently selected from R b and oxo; R wherein alkyl, and cycloalkyl are optionally substituted with one, two, or three substituents independently selected from R a ; R wherein alkyl, alkenyl, alkynyl and cycloalkyl are optionally substituted with one, two, three or four substituents independently selected from R a , and cycloheteroalkyl, aryl and heteroaryl are optionally substituted with one, two, three or four substituents independently selected from R b ; R wherein alkyl, alkenyl, alkynyl, and cycloalkyl may be optionally substituted with one or two R a substituents, and aryl may be optionally substituted with one or two R b substituents, or R 5 and R 6 together form ═CH—N(R e )(R f ); Ar wherein aryl and heteroaryl are optionally substituted with one, two, three or four substituents independently selected from R b ; each R each R wherein aryl and heteroaryl are unsubstituted or substituted with one, two or three substituents independently selected from R h ; each R wherein alkyl, cycloalkyl, cycloheteroalkyl, phenyl, and heteroaryl may be substituted with one or two R h substituents, and alkyl, cycloalkyl, cycloheteroalkyl may be substituted on a carbon or sulfur atom with one or two oxo substituents; each R R when bonded to the same atom, R each R R wherein each alkyl may be unsubstituted or substituted with one, two or three R a substituents, and each aryl may be unsubstituted or substituted with one, two or three R b substituents; each R m is selected from 1 and 2; and n is selected from 1, 2, and 3; or a pharmaceutically acceptable salt thereof.