Patent ID: 8828685
Filing Date: 2014-09-09
Classification: A61K,A61P,C07K,C12N,C12Y,Y02A

Abstract:
1. A method of increasing an inflammatory response in a subject, comprising administering to the subject the modified tyrosyl-tRNA (TyrRS) synthetase polypeptide having a non-canonical biological activity, wherein the polypeptide is substantially in a monomeric form under physiological conditions or in solution, and comprises one or more stabilizing modifications relative to a wild-type TyrRS sequence that reduce its ability to dimerize with itself or with another TyrRS polypeptide wherein said TyrRS polypeptide comprises a deletion of amino acid Pro 159, Leu160 and Leu161 (Δ159-161) relative to SEQ ID NO: 3.