Patent ID: 9217745
Filing Date: 2015-12-22
Classification: C12N,G01N

Abstract:
1. A detection system comprising: an arrayed imaging reflectometry (AIR) sensor chip suitable for the detection of influenza immune responses comprising: a multilayer substrate comprising a surface comprising hemagglutinin polypeptides from different influenza strains or isolates, wherein said hemagglutinin polypeptides comprise a hemagglutinin epitope and are covalently attached to the surface at different locations and retain conformational epitopes that are capable of binding to anti-influenza antibodies; a light source that is positioned to illuminate the sensor chip; and a detector that is positioned to detect light reflected from the surface of the chip, and thereby determine whether an antibody binds to the hemagglutinin polypeptides, wherein a destructive interference of polarized light illuminating the surface occurs in an absence of antibody binding and antibody binding produces a change in reflectance detectable by the detector.