Patent ID: 6545000
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A [1,2,4]triazolo[1,5-c]pyrimidine compound represented by formula (I): whereinR1 represents substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; R2 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; na and nb independently represent an integer of 0 to 4; Q represents a hydrogen atom or 3,4-dimethoxybenzyl; R6 represents a hydrogen atom, substituted or unsubstituted lower alkyl, halogen, or hydroxy; R3 represents (I) hydroxy, (ii) hydroxy-lower alkyl, (iii) substituted or unsubstituted lower alkoxy, or (iv) is selected from the group consisting of substituted or unsubstituted imidazo[1,2-a]pyridyl, substituted or unsubstituted imidazo[1,2-a]pyrazinyl, substituted or unsubstituted imidazo[1,2-a]pyrimidinyl, substituted or unsubstituted benzimidazolyl, substituted or unsubstituted benzothiazolyl, substituted or unsubstituted benzo-2,1,3-thiadiazolyl, substituted or unsubstituted isoxazolyl, and substituted or unsubstituted 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl; or a pharmaceutically acceptable salt thereof, with the provisos (i) when R3 represents hydroxy, hydroxy-lower alkyl, or substituted or unsubstituted lower alkoxy, then R4 and R5 independently represent substituted or unsubstituted lower alkyl or substituted or unsubstituted aryl, or R4 and R5 form a substituted or unsubstituted saturated carbocycle together with the adjacent carbon atom, and (ii) when R3 is selected from the group consisting of substituted or unsubstituted imidazo[1,2-a]pyridyl, substituted or unsubstituted imidazo[1,2-a]pyrazinyl, substituted or unsubstituted imidazo[1,2-a]pyrimidinyl, substituted or unsubstituted benzimidazolyl, substituted or unsubstituted benzothiazolyl, substituted or unsubstituted benzo-2,1,3-thiadiazolyl, substituted or unsubstituted isoxazolyl, and substituted or unsubstituted 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl, then R4 and R5 independently represent a hydrogen atom, substituted or unsubstituted lower alkyl, or substituted or unsubstituted aryl, or R4 and R5 form a substituted or unsubstituted saturated carbocycle together with the adjacent carbon atom.