Patent ID: 6815574
Filing Date: 2004-11-09
Classification: A01K,A61K

Abstract:
A method for simulating progression of human prostate cancer from primary tumor formation to micrometastasis or macrometastasis in an animal model, comprising:a. providing an immune deficient mouse comprising a human prostate cancer xenograft of locally advanced or metastatic prostate cancer tissue, or a cell suspension thereof implanted in the mouse; b. allowing the xenograft to grow for a time sufficient to permit the detection of prostate cancer cells within the implant site in the mouse; and, c. allowing the xenograft to grow for an additional time sufficient to permit the detection of prostate cancer cells external to the implant site in the mouse, thereby simulating the progression of human prostate cancer from primary tumor formation to micrometastasis or macrometastasis in the animal model.