Patent ID: 8093254
Filing Date: 2012-01-10
Classification: A61P,C07D

Abstract:
1. A compound having the structural Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein R p is an integer from 0 to 5; the dashed line ( ring A together with V and X forms a mono or multicyclic 4 to 12 membered cycloalkylene, cycloalkenylene, heterocycloalkylene or heterocycloalkenylene wherein the heteroatom or heteroatoms of said heterocycloalkylene or heterocycloalkenylene are independently selected from the group consisting of —O—, —S—, —S(O)—, —S(O) or ring A together with V and X forms a mono or multicyclic 4 to 12 membered arylene or heteroarylene; W is —S(O)—, —S(O) X is —N— or —C(R Y is —N(R Z is a bond, —N(R or Z and Y taken together is —C═C—, —N═C— or —C═N—; or X and Y taken together is —C═C—, —N═C— or —C═N—; V is —C(R or V and X taken together forms —C═C—; with the proviso that there are no cumulative double bonds between V, X, Y, Z and the ring atoms of ring A adjacent to V and X; each of R each of R or a R each R each R or two R each R each R each of R each of R each R or two R each R each R and wherein each of the alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, in R is independently unsubstituted or substituted by 1 to 5 R and wherein each of the alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl and heterocycloalkenylheteroaryl groups in R or two R and when R each R each of R R each R each R each R or two R each R or R or two R