Patent ID: 6933319
Filing Date: 2005-08-23
Classification: A61K,A61Q,C07C,C07D

Abstract:
1. A method of lightening skin or reducing the pigmentation of skin in a human, comprising administering to said human a skin-lightening or skin pigmentation-reducing effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R wherein n is 0, 1, 2 or 3, where such (C 5 -C 8 )cycloalkyl ring or (C 5 -C 8 )cycloalkenyl ring is substituted by hydroxy, (C 1 -C 6 )alkoxy-, aryl(C 1 -C 6 )alkoxy-, —OC(O)(C 1 -C 6 )alkyl, —OC(O)aryl(C 1 -C 6 )alkyl, —OC(O)phenyl, halo, (C 1 -C 6 )alkyl-, aryl(C 1 -C 6 )alkyl-, —SH, —S(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkyl-S—, —NH 2 , —NH(C 1 -C 6 )alkyl, or aryl(C 1 -C 6 )alkyl-HN—; then the (C 5 -C 8 )cycloalkyl ring or the (C 5 -C 8 )cycloalkenyl ring must be di- or tri-substituted.