Patent ID: 6166048
Filing Date: 2000-12-26
Classification: A61K,A61P,C07D,Y02A

Abstract:
A method for inhibiting cytokine production and/or secretion, the method comprising administering an effective amount of a compound having the formula: ##STR4## where X and X' are individually carbon or nitrogen bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0, A, A' and A"" individually are substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; B' is selected from the group consisting of oxygen, nitrogen-containing moiety, sulfur,--(CE'E"")--(CE'E"")--,--CE'E""--X""--, ##STR5##--C.tbd.C--wherein X"" is oxygen, nitrogen-containing or sulfur; m is an integer and n is an integer such that the sum of m plus n is 1, 2, 3, 4, 5, 6, 7, or 8; E.sup.I, E.sup.II, E.sup.III, E.sup.IV, E.sup.V and E.sup.VI individually represent hydrogen, lower alkyl or halo substituted lower alkyl; Z' and Z"" individually are hydrogen or lower alkyl; and the wavy line in the structural moiety indicates that the compound can have a cis (Z) or trans (E) form.