Patent ID: 9066996
Filing Date: 2015-06-30
Classification: A61L,C12M

Abstract:
1. A method for selectively degrading a three-dimensional biological scaffold, comprising: providing a three-dimensional biodegradable biological scaffold in an aqueous medium, wherein the scaffold is comprised of a polymer; subjecting the scaffold to a treatment capable of selectively degrading the polymer, the treatment selected from the group consisting of base, acid, oxidation, heat and combinations thereof, wherein the treatment includes an effective amount of base, acid, oxidant, heat or combinations thereof that is capable of partially degrading the polymer, wherein the effective amount of heat includes temperatures between about 80° C. to about 250° C.; and incubating the scaffold under conditions which create a partially degraded three-dimensional biodegradable biocompatible biological scaffold; wherein the three-dimensional biodegradable biocompatible biological scaffold is a three-dimensional ordered open-cellular polymer structure which (i) is formed by a plurality of polymer waveguides which interpenetrate each other at a plurality of nodes and (ii) has a micro-truss architecture comprising a repeating pattern of ordered interconnected pores; wherein the three-dimensional ordered open-cellular polymer structure is made by photopolymerization of a monomer composition, the monomer composition comprising: a first molecule comprising at least one C═C double bond or C≡C triple bond; a second molecule having the structure R—X a photoinitiator.