Patent ID: 6498138
Filing Date: 2002-12-24
Classification: C12N

Abstract:
A method for accelerating the production of a tissue equivalent comprising contacting the tissue equivalent with an amount effective to accelerate generation of tissue equivalents of at least one active agent comprising a sequence of at least three contiguous amino acids of groups R1-R8 in the sequence of general formula IR1-R2-R3-R4-R5-R6-R7-R8 wherein R1 is selected from the group consisting of Asp, Glu, Asn, Acpc, Ala, Me 2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2) and Suc; R2 is selected from the group consisting of Arg, Lys, Ala, Orm, Ser(Ac), Sar, D-Arg and D-Lys; R3 is selected from the group consisting of Val, Ala, Leu, norLeu, Ile, Gly, Pro, Aib, Acpc, Lys and Tyr; R4 is selected from the group consisting of Tyr, Tyr(PO3)2, Thr, Ser, Ala, homoSer and azaTyr; R5 is selected from the group consisting of Ile, Ala, Leu, norLeu, Val and Gly; R6 is selected from the group consisting of His, Arg and 6-NH2-Phe; R7 is selected from the group consisting of Pro and Ala; and R8 is selected from the group consisting of Phe, Phe(Br), Ile and Tyr, excluding sequences including R4 as a terminal Tyr group.