Patent ID: 8722694
Filing Date: 2014-05-13
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) wherein R R X denotes a nitrogen atom, A denotes —NH— wherein the H is optionally is replaced by a C B denotes a carbonyl or sulfonyl group, C denotes a 1,3-allenylene, 1,1- or 1,2-vinylene group which may be substituted in each case by one or two methyl groups or by a trifluoromethyl group, an ethynylene group or a 1,3-butadien-1,4-ylene group optionally substituted by 1 to 4 methyl groups or by a trifluoromethyl group, D denotes an alkylene, —CO-alkylene or —SO a —CO—O-alkylene, —CO—NR or, if D is bound to a carbon atom of the group E, it may also denote a bond or, if D is bound to a nitrogen atom of the group E, it may also denote a carbonyl or sulfonyl group, E denotes an amino, C a C an N—(C a di-(C a C an amino or C a 4- to 7-membered alkyleneimino group optionally substituted by 1 to 4 C a piperidino group substituted by a tetrahydrofuranyl, tetrahydropyranyl or tetrahydrofuranylmethyl group, a 6- to 7-membered alkyleneimino group optionally substituted by 1 or 2 C an imidazolyl group optionally substituted by 1 to 3 methyl groups, a C or D together with E denotes a hydrogen, fluorine or chlorine atom, a C a C an aryl, heteroaryl, C a carboxy, C a carbonyl which is substituted by a 4- to 7-membered alkyleneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups in each case a methylene group may be replaced in the 4 position by an oxygen or sulfur atom, by an imino group substituted by the group R R an C a 3-pyrrolidinyloxy, 2-pyrrolidinyl-C by the aryl moieties mentioned in the definition of the abovementioned groups is meant a phenyl group which in each case may be monosubstituted by R and the heteroaryl groups mentioned in the definition of the abovementioned groups include a 5-membered heteroaromatic group which contains an imino group, an oxygen or sulfur atom or an imino group, an oxygen or sulfur atom and one or two nitrogen atoms, or a 6-membered heteroaromatic group which contains one, two or three nitrogen atoms, whilst the abovementioned 5-membered heteroaromatic groups may be substituted in each case by 1 or 2 methyl or ethyl groups and the abovementioned 6-membered heteroaromatic groups may be substituted in each case by 1 or 2 methyl or ethyl groups or by a fluorine, chlorine, bromine or iodine atom or by a trifluoromethyl, hydroxy, methoxy or ethoxy group, or a tautomer, stereoisomer or pharmaceutically acceptable salt thereof.