Patent ID: 6596859
Filing Date: 2003-07-22
Classification: C07H

Abstract:
A process for the production of a compound of the formula: and enantiomers thereof where wherein R1 is hydrogen, alkyl, C1-Cl16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cyano, carboxy, carboxy esters, carboxamido N-mono substituted and N,N-disubstituted carboxamido with alkyl, aralkyl or aryl groups; where R2 is hydrogen, alkyl, C1-C16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl; and where R3 is alkyl C2-C6, branched alkyl, aryl C2-C6, substituted aryl; and where R6 is alkyl C2-C6, branched alkyl, aryl C2-C6, substituted aryl which comprises: effecting a condensation reaction on a compound of the formula: with a compound of the formula: to form a compound of the formula: acylating compound (2) with a compound of the formula: R3COCl to form a compound of the formula: mixing compound (6) with pyridine to form a reaction mixture; adding to the reaction mixture a component selected from the group consisting of alkyl and aryl sulfonyl halide to the reaction mixture to produce a compound of the formula: and mixing compound (7) with pyridine and thionyl chloride to produce compound (8).