Patent ID: 8703797
Filing Date: 2014-04-22
Classification: A61P,C07D

Abstract:
1. A method of wound healing, treating wet and dry age-related macular degeneration, geographic atrophy, glaucomatous optic neuropathy, or vision threatening retinopathies associated with the sphingosine-1-phosphate 2 receptor modulation, wherein the retinopathy is selected from: diabetic retinopathy and retinopathy of prematurity, which comprises administering to a patient in need thereof, a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein: A is a direct bond or (CR) and B, C and D are independently selected from the group consisting of (CR) and N, wherein R is H or alkyl, provided however, not all, of B, C and D are N and, when A is a direct bond, D is (CR); R X is selected from the group consisting of O, NR Y is selected from the group consisting of O or S; and Z is a substituted aryl ring.