Patent ID: 6063569
Filing Date: 2000-05-16
Classification: C07D,C07H,C07K,Y02P

Abstract:
A synthetic, substantially pure composition of matter comprising:KLQMNwhereinK and N are chemical bonds;Q is a linker or chemical bond;one of L and M is a nucleotide moiety of the formula: ##STR70## wherein G is a secondary nitrogen atom, a tertiary nitrogen atom having an alkyl substituent, an oxygen atom or a sulfur atom;B is a natural or unnatural nucleobase comprising a bond linking a nucleobase protecting group to the natural or unnatural nucleobase; andD is a hydrogen atom, a hydroxyl group, a methoxyl group or a hydroxyl group which is protected by a protecting group;the other of L and M is a PNA moiety of the formula: ##STR71## wherein G is a secondary nitrogen atom, a tertiary nitrogen atom having an alkyl substituent, an oxygen atom or a sulfur atom;B is a natural or unnatural nucleobase comprising a bond linking a nucleobase protecting group to the natural or unnatural nucleobase;R.sup.7 is selected from the group consisting of hydrogen and a side chain of a protected or unprotected naturally occurring .alpha. amino acid; andeach of j, g and h is the same or different and is independently zero or an integer from one to five; andwherein the bonds linking the nucleobase protecting groups to the natural or unnatural nucleobases of both said PNA moiety and said nucleotide moiety are broken under the same conditions during the same time interval.