Patent ID: 6177424
Filing Date: 2001-01-23
Classification: C07D

Abstract:
A 4'-substituted-4,8-dimethyl-4',5'-dihydropsoralen of formula (V): ##STR10##whereinR is hydrogen, a halogen, CN, or an acyl group;T is a halogen, CN a carboxylate, a carboalkoxy group or a group defined by NR.sup.1 R.sup.1 or (N.sup.+ R.sup.1 R.sup.2 R.sup.3)X.sup.-,R.sup.1 and R.sup.2 are independently a C1-C6alkyl, or R.sup.1 and R.sup.2 together with the nitrogen form a 5-8 member heterocyclic ring, or when T is a group defined by (N.sup.+ R.sup.1 R.sup.2 R.sup.3)X.sup.-, R.sup.1 and R.sup.2 together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring,R.sup.3 is hydrogen, a C1-C12alkyl, or, when R.sup.1 and R.sup.2 together with the nitrogen form a heterocyclic aromatic ring, R.sup.3 is a double bond within the heterocyclic aromatic ring;X is a halide;or a pharmaceutically acceptable salt thereof.