Patent ID: 7833547
Filing Date: 2010-11-16
Classification: A61K,A61P,Y10S

Abstract:
1. A pharmaceutical composition comprising: (a) an effective amount of ibuprofen wherein the weight of the ibuprofen is provided in a range, of the total weight of the tablet composition, of up to about 50%; (b) an effective amount of hydrocodone; (c) colloidal silicon dioxide provided in a range, by total weight of the tablet composition, of about 1.5% to about 2%; (d) microcrystalline cellulose provided in a range, of the total weight of the tablet composition, of about 15% to about 25%; (e) a disintegrant selected from the group consisting of croscarmellose sodium and crospovidone wherein the weight of the disintegrant is provided in a range, of the total weight of the tablet composition, of about 6 to about 8%; (f) a binder consisting of an alkylhydroxy methylcellulose wherein the weight of the binder is provided in a range, of the total weight of the tablet composition, of about 3% to about 4%; (g) corn starch wherein the weight of the corn starch is provided in a range, of the total weight of the tablet composition, of about 11 to about 17%; and (h) a lubricant wherein the weight of the lubricant is provided in an amount less than 1% by weight of the total weight of the tablet, wherein not less than 70% of the ibuprofen or the hydrocodone is released at 30 minutes in 900 mL of pH phosphate buffer, at 37° C. using baskets at 150 revolutions per minute, wherein said composition has acceptable disintegration, dissolution and compression characteristics wherein the tablet has compression forces from 5 to 20 kN with no substantial change in the disintegration time of the tablet, and wherein said composition is substantially free of lactose.