Patent ID: 9161991
Filing Date: 2015-10-20
Classification: A61K,A61P,C07K

Abstract:
1. A fusion protein comprising: domain (a) which is a functional fragment of human Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (hTRAIL) protein, wherein said fragment begins with an amino acid at a position not lower than hTRAIL95 and ends with the amino acid at position hTRAIL281, or a homolog of said functional fragment having at least 70% sequence identity; and domain (b) which is an immunostimulating effector peptide selected from the group consisting of pseudodimer of interferon gamma of SEQ ID NO: 19 and the pseudodimer of interferon alpha 2b of SEQ ID NO: 46; wherein domain (b) is attached at the C-terminus or N-terminus of domain (a) and wherein hTRAIL has the sequence set forth as SEQ ID NO: 16.