Patent ID: 6552079
Filing Date: 2003-04-22
Classification: C07C,C07D

Abstract:
A compound having the formula: wherein:Y is selected from the group consisting of â€”COOH and â€”COOR4; where R4 is selected from the group consisting of C1-10alkyl, C1-8alkylaryl, and aryl-C1-8alkyl; A is selected from the group consisting of C0-8alkyl-NR5â€”COâ€”C0-8alkyl, C0-8alkyl-COâ€”NR5â€”C0-8alkyl, C0-8alkyl-NR5 â€”COâ€”C1-8alkyl-NR5 â€”COâ€”C0-8alkyl, C0-8alkyl-COâ€”NR5â€”C1-8alkyl-NR5â€”COâ€”C0-8alkyl, C0-8alkyl-COâ€”NR5â€”C0-8alkyl-COâ€”NR5â€”C0-8alkyl, C0-8alkyl-COâ€”C1-8alkylâ€”COâ€”NR5â€”C0-8alkyl, C0-8alkyl-NR5â€”C0-8alkyl-COâ€”NR5â€”C0-8alkyl, C0-8alkyl-Oâ€”C0-8alkyl-COâ€”NR5â€”C0-8alkyl, and C0-8alkyl-Oâ€”C2-8alkyl-Oâ€”C0-8alkyl-COâ€”NR5â€”C0-8alkyl; where R5 are independently selected from the group consisting of H and C1-6alkyl; Z is selected from the group consisting of â€”NHâ€”C(NR9R10)&boxH;NR11 and â€”C(NR9R10)&boxH;NR; where R9, R10 and R11 are independently selected from the group consisting of H and C1-6alkyl; R1 is H; R2 is selected from the group consisting of â€”SOm-aryl and â€”SOmâ€”C1-10alkyl, where m=2; and R3 is H; and all pharmaceutically-acceptable stereoisomers, salts, hydrates, solvates and prodrug derivatives thereof.