Patent ID: 7407779
Filing Date: 2008-08-05
Classification: A61K,A61P,C12P

Abstract:
1. A method for modifying ungranulated/solid matrix 3-sn-phosphoglyceride molecules, comprising forming a reaction mixture by contacting ungranulated/solid matrix 3-sn-phosphoglyceride molecules with an amount of phospholipase A adding to the reaction mixture one or more fatty acids and one or more agents selected from the group consisting of monoglyceride; diglyceride; polyglycerol fatty acid ester; sucrose fatty acid ester; sorbitan fatty acid ester; glycerol and other alcohol functional groups including serine and ethanolamine; and solvents; and incubating the reaction mixture to hydrolyze the 2-acyl bond, wherein the ungranulated/solid matrix 3-sn-phosphoglyceride molecules are hydrolyzed with >99% efficiency and wherein the hydrolysis of the ungranulated/solid matrix 3-sn-phosphogglyceride molecules is complete within 7 hours.