Patent ID: 6225431
Filing Date: 2001-05-01
Classification: C07F,C08F

Abstract:
A biocompatibilising process in which the surface of a medical device is coated with a coating composition comprising a polymer dispersed or dissolved in a solvent and the solvent is removed to leave a stable coating of polymer on the surface, wherein the polymer is formed by the radical polymerization of ethylenically unsaturated monomers comprisingi) a monomer of the formula IY-B-Xin which Y is selected from groups ##STR23##in which R is hydrogen or C.sub.1-4 -alkylA is O or NR.sup.1 where R.sup.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl and groups BXK is a group --(CH.sub.2).sub.p OC(O)--, [--(CH2).sub.p C(O)O--]--(CH.sub.2).sub.p C(O)O--, --(CH.sub.2).sub.p OC(O)O--, --(CH.sub.2).sub.p NR.sup.2 -, --(CH.sub.2).sub.p NR.sup.2 C(O)--, --(CH.sub.2).sub.p C(O)NR.sup.2 -, --(CH.sub.2).sub.p NR.sup.2 C(O)O--, --(CH.sub.2).sub.p OC(O)NR.sup.2 -, --(CH.sub.2).sub.p NR.sup.2 C(O)NR.sup.2 - (in which the groups R.sup.2 are the same or different), --(CH.sub.2).sub.p O--, --(CH.sub.2).sub.p SO.sub.3 --, or, optionally in combination with B, a valence bond and p is from 1 to 12 and R.sup.2 is hydrogen or a C.sub.1 -C.sub.4 alkyl group;B is a straight or branched alkylene, optionally interrupted by one or more oxygen atoms, and optionally substituted by one or more fluorine atoms,X is a group IVB ##STR24##in which the groups R.sup.6 are the same or different and are selected from hydrogen and C.sub.1-4 -alkyl groups and d is 2 to 4; andii) a comonomer which is an ethylenically unsaturated compound, wherein the comonomer has the general formula (XII)Y.sup.2 -B.sup.9 -Q.sup.5 (XII)where Y.sup.2 is an ethylenically unsaturated polymerisable group of the formula ##STR25##where R.sup.26 is hydrogen or methyl;B.sup.9 is a valence bond or a straight alkylene group of the formula --(Cr.sup.22.sub.2).sub.r -- in which each R.sup.22 is hydrogen and r is 1 to 12; andQ.sup.5 is a surface-binding group selected from cationic groups of the formula --N.sup.+ R.sup.31.sub.3 wherein the groups R.sup.31 are the same or different and are each selected from hydrogen and C.sub.1-4 alkyl, a group N.sup..sym. Het, where Het is an unsaturated heterocyclic group, substituted or unsubstituted by one or more alkyl groups of 1 to 4 carbon atoms, or a group --PR.sup.32.sub.3.sup..sym. in which each group R.sup.32 is the same or different and is hydrogen or alkyl of 1 to 6 carbons atoms, two of which groups R.sup.31 may together form a heterocyclic ring containing from 5 to 7 atoms, anionic groups selected from the group consisting of carboxylate, sulphonate, hydrogen phosphate and phosphate groups; reactive groups selected from the group consisting of cross-linkable ethylenically unsaturated groups; acetylenically unsaturated groups; silane and siloxane groups containing one or more substituents selected from halogen atoms and C.sub.1-4 -alkoxy groups; hydroxyl; amino; carboxyl; epoxy; --CHOHCH.sub.2 Hal (in which Hal is selected from chlorine, bromine and iodine atoms) succimimido; tosylate; triflate; imidazolecarbonylamino; optionally substituted triazine; cinnamyl; acetoacetoxy; methylol; chloroalkylsulphone; acetoxy; mesylate; carbonyldi(cycloalkyl carbodiimidoyl) and oxyimino;straight or branched C.sub.6-24 -alkyl groups;fluoroalkyl groups of the formula (CR.sup.17.sub.2).sub.m CR.sup.17.sub.3 wherein the groups (CR.sup.17.sub.2) are the same or different, and in each group (CR.sup.17.sub.2) the groups R.sup.17 are the same and each group R.sup.17 is fluorine or C.sub.1-4 -fluoroalkyl and m is 1 to 23; andsiloxane groups --(CR.sup.16a.sub.2).sub.qq (SiR.sup.16b.sub.2)(OSiR.sup.16b.sub.2).sub.pp R.sup.16b in which each group R.sup.16a is hydrogen, each group R.sup.16b is methyl, gg is from 1 to 6 and pp is from 0 to 49.