Patent ID: 7501114
Filing Date: 2009-03-10
Classification: A61K,C12N

Abstract:
1. A method for inhibiting restenosis or intimal hyperplasia in a mammal, said method comprising the steps of: evacuating a clot from a blood vessel in said mammal; isolating a segment of the blood vessel around the evacuation site; and infecting the segment of blood vessel in vivo using a gutless adenoviral vector comprising a polynucleotide encoding a functional thrombomodulin protein or its variant; wherein the functional thrombomodulin protein or its variant is under the control of a regulatory element and is expressed in an amount sufficient to reduce re-occlusion or intimal hyperplasia in the infected blood vessel, and wherein said gutless adenoviral vector comprises the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15.