Patent ID: 7297704
Filing Date: 2007-11-20
Classification: A61P,C07D

Abstract:
1. A compound which is: N-[(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3S)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3R)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(6-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3S)-6-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3R)-6-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3R)-6,8-difluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3S)-6,8-difluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; [(5-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(5-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(7-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; (3S)-3-[({[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amino)methyl]-2,3,4,9-tetrahydro-1H-carbazole-6-carbonitrile; (3R)-3-[({[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amino)methyl]-2,3,4,9-tetrahydro-1H-carbazole-6-carbonitrile; 2-(6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)ethyl]{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {2-[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]ethyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {2-[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]ethyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; (2R)-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; (2S)-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; 6-Fluoro-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; 6-Fluoro-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; (2R)-6-Fluoro-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; (2S)-6-Fluoro-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-2-amine; [(8-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thien-2-yl)methyl]{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}(1,2,3,4-tetrahydrodibenzo[b,d]thien-2-ylmethyl)amine; {[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}(1,2,3,4-tetrahydrodibenzo[b,d]thien-2-ylmethyl)amine; N-{[(3S)-6-trifluoromethoxy-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}ethanamine; N-[(6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}propan-1-amine; (Cyclopropylmethyl)[(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]([(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-[(6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclobutanamine; N-{[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}propan-1-amine; (Cyclopropylmethyl){[(3R)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclobutanamine; N-{[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}propan-2-amine; N-{[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}butan-2-amine; N-{[(3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclopentanamine; N-{[(3R)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclohexanamine; N-{[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}propan-2-amine; N-{[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}butan-2-amine; N-{[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclopentanamine; N-{[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclohexanamine; N-[(6-Fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}propan-2-amine; N-[(6-Fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclopentanamine; N-[(6-Fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}cyclohexanamine; {[(3S)-6-Fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}methyl{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {[(3R)-6-Fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}methyl{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine 5,6-Dichloro-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-(8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl)-amine; (6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-(8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl)-amine; (5-Chloro-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-(8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl)-amine; (7-Chloro-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-(8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl)-amine; (6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-(8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl)-amine; (7,8-Dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]naphthalen-8-(S)-ylmethyl)-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(S)-ylmethyl)-amine; (7,8-Dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]naphthalen-8-(S)-ylmethyl)-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(R)-ylmethyl)-amine; (2,3-Dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(R)-ylmethyl)-amine; (2,3-Dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(S)-ylmethyl)-amine; (6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(R)-ylmethyl)-(7-methyl-2,3-dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-amine; (6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(S)-ylmethyl)-(7-methyl-2,3-dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-amine; (6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(R)-ylmethyl)-(6-methyl-2,3-dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-amine; (6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-(S)-ylmethyl)-(6-methyl-2,3-dihydro-1,4-dioxa-5,8-diaza-phenanthren-3-(S)-ylmethyl)-amine; {[(2R)-8-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thien-2-yl]methyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {[(2S)-8-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thien-2-yl]methyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}[(2S)-1,2,3,4-tetrahydrodibenzo[b,d]thien-2-ylmethyl]amine; {[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}[(2R)-1,2,3,4-tetrahydrodibenzo[b,d]thien-2-ylmethyl]amine; {[(3R)-7-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thien-3-yl]methyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; {[(3S)-7-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thien-3-yl]methyl}{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3S)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; N-{[(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine; (3R)-6-fluoro-N-{(2S)-8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-3-amine; (3S)-6-fluoro-N-{(2S)-8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazol-3-amine; [(2S)-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-ylmethyl]{[(3S)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}amine; [(2S)-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-ylmethyl]{[(3R)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}amine; or a pharmaceutically acceptable salt thereof.