Patent ID: 8044086
Filing Date: 2011-10-25
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound 4-[6-(4-fluoro-phenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-phenylcarbamoyl-hexahydro-1,2-dioxa-5 a-aza-cyclopropa[a]inden-3-yl]-3-(R)hydroxy-butyric acid or 4-[1b-(4-fluoro-phenyl)-6-hydroxy-6-isopropyl-1a-phenyl-6a-phenylcarbamoyl-hexahydro-1,2-dioxa-5 a-azacyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid characterized in that a solid atorvastatin salt is oxidized in an air or oxygen atmosphere at an elevated temperature from 40 to 90° C.