Patent ID: 6828329
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: represents: wherein:C and D are CR1, and E represents sulfur, where R1, at each occurrence, is independently selected from the group consisting of hydrogen, halogen, cyano, halo (C1-6)alkyl, halo (C1-6)alkoxy, hydroxy, C1-6 alkyl, amino, mono and di(C1-6)alkylamino and C1-6 alkoxy; and R2 is selected from the group consisting of hydrogen, halogen, cyano, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, hydroxy, C1-6 alkyl, amino, and mono or di(C1-C6)alkylamino; W is phenyl which is unsubstituted or substituted with 1, 2, 3, 4, or 5 R3 groups or naphthyl which is unsubstituted or substituted with 1, 2, 3, 4, 5, 6, or 7 R3 groups; and Q is pyridinyl, which is unsubstituted or substituted with 1, 2, 3, or 4 R4 groups; R3 and R4 at each occurrence are independently selected from the group consisting of hydrogen, halogen hydroxy, â€”OR6, â€”NO2, â€”CN, â€”SO2NH2, â€”SO2NHR6, â€”SO2N(R6)2, amino, â€”NHR6, â€”N(R6)2, â€”N(R6)CO(R6), â€”N(R6)CO2(R6), â€”CONH2, â€”CONH(R6), â€”CON(R6)2, â€”CO2(R6), â€”S(R6), â€”SO(R6), â€”SO2(R6), and R7, wherein R6, at each occurrence, is independently C1-8 alkyl, which is unsubstituted or substituted with one or two substituents independently selected from the group consisting of hydroxy, oxo, halogen, amino, and C1-8 alkoxy, R7 at each occurrence is independently C1-8 alkyl, which is unsubstituted or substituted with one or two substituents independently selected from the group consisting of hydroxy, oxo, halogen, â€”OR6, â€”NO2, â€”CN, â€”SO2NH2, â€”SO2NHR6, â€”SO2N(R6)2, amino, â€”NHR6, â€”N(R6)2, â€”N(R6)CO(R6), â€”N(R6)CO2(R6), â€”CONH2, â€”CONH(R6), â€”CON(R6)2, â€”CO2H, â€”CO2(R6), â€”S(R6), â€”SO(R6), and â€”SO2(R6), X is â€”(CH2)nâ€” or â€”(CH2)n(C&boxH;O)â€”, wherein each n is independently 1, 2, or 3.