Patent ID: 6180086
Filing Date: 2001-01-30
Classification: A61K,A61P,C09B

Abstract:
A composition comprising cyanine dyes of formula ##STR7##wherein a.sub.3 and b.sub.3 are independently 0 to 5; W.sup.3 and X.sup.3 are independently selected from the group consisting of C((CH.sub.2).sub.zz OH).sub.2, C((CH.sub.2).sub.zz CO.sub.2 H).sub.2, and C((CH.sub.2).sub.zz NR.sub.pp R.sub.pz).sub.2 ; and zz is from 1 to 5; R.sub.pp and R.sub.pz are independently selected from the group consisting of --(CH.sub.2).sub.c --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.d --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.g --N(R.sup.14)--(CH.sub.2).sub.h --CO.sub.2 H, and --(CH.sub.2).sub.i --N(R.sup.15)--CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.j --CH.sub.2 --CO.sub.2 H; Y.sup.3 and Z.sup.3 are independently selected from the group consisting of --(CH.sub.2).sub.c --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.d --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.e --NH.sub.2, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.f --CH.sub.2 --NH.sub.2, --(CH.sub.2).sub.g --N(R.sup.14)--(CH.sub.2).sub.h --CO.sub.2 H, and --(CH.sub.2).sub.i --N(R.sup.15)--CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.j --CH.sub.2 --CO.sub.2 H; A.sub.1 is a single or a double bond; if A.sub.1 is a single bond, then B.sub.1 and C.sub.1 are independently selected from the group consisting of --O--, --S--, --Se--, --P-- and --NR.sup.38 ; and D.sub.1 is selected from --CR.sup.39 R.sup.40 and --C.dbd.O; if A.sub.1 is a double bond, then B.sub.1 is selected from the group consisting of --O--, --S--, --Se--, --P-- and --NR.sup.38, C.sub.1 is selected from nitrogen and --CR.sup.41 and D.sub.1 is --CR.sup.42 ; R.sup.29 to R.sup.37 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, hydroxyl, C1-C10 alkoxyl, cyano, nitro, halogen, and --NR.sup.43 R.sup.44 ; R.sup.14, R.sup.15, and R.sup.38 to R.sup.42 are independently selected from the group consisting of -hydrogen, C1-C10 alkyl, C1-C10 alkoxyl, --CH.sub.2 (CH.sub.2 --O--CH.sub.2).sub.c --CH.sub.2 --OH, --(CH.sub.2).sub.d --CO.sub.2 H, --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.e --CH.sub.2 --CO.sub.2 H, --(CH.sub.2).sub.f --NH.sub.2, and --CH.sub.2 --(CH.sub.2 --O--CH.sub.2).sub.g --CH.sub.2 --NH.sub.2 ; c, e, g, h, and i are independently from 1 to 10; d, f and j are independently from 1 to 100; R.sup.43 and R.sup.44 are independently selected from the group consisting of hydrogen, and C1-C10 alkyl, and a pharmaceutically acceptable carrier or excipient.