Patent ID: 6417174
Filing Date: 2002-07-09
Classification: A61K,A61P

Abstract:
A method of treating a bacterial infection comprising administering to an animal suffering from such an infection an effective amount of a compound having the formula:â€ƒ(OH)2â€”Bâ€”Râ€ƒâ€ƒ(1)wherein:R is naphthalene, phenanthrene, or has one of the following formulas: wherein:ring system (2), (3), (4), (5), (6), (7), (8), (9) or (10) is aromatic or nonaromatic; the atom center * is (R) or (S) in the case of chiral compounds; positions 1, 2, 3, 4, 5, 6, 7 or 8 each independently is C, N, O or S; R1 through R6 each independently is a lone pair, H, B(OH)2, a halogen atom, CF3, CH2CF3, CCl3, CH2CCl3, CBr3, CH2CBr3, NO2, lower alkyl, CO2H, CHCHCOOH, CH2CH2CH2COOH, SO3H, PO3H, OSO3H, OPO3H, OH, NH2, CONH2, COCH3, OCH3, or phenyl boronic acid, except that R2, R3, R4, R5 and R6 cannot all simultaneously be H, R2 cannot be lower alkyl when R3, R4, R5 and R6 are H, R3 cannot be NH2, OH or lower alkyl when R2, R4, R5 and R6 are H, and R4 cannot be lower alkyl when R2, R3, R5 and R6 are H; R7 is a lone pair, H, B(OH)2, a halogen atom, CF3, CCl3, CBr3, CH2CF3, CH2CCl3, CH2CBr3, NO2, CONH2, COCH3, OCH3, lower alkyl, aryl, aryl substituted with one or more substituents R8, heteroaryl, or heteroaryl substituted with one or more substituents R8; each R8 is independently a lone pair, H, B(OH)2, a halogen atom, CF3, CCl3, CBr3, CH2CF3, CH2CCl3, CH2CBr3, NO2, lower alkyl, O, N, S, OH, NH2, N(CH3)2, N(CH3)CH2CH3, NCOCH3, COOH, CHCHCOOH, CH2CH2CH2COOH, CONH2, COCH3, OCH3, OCl or phenyl boronic acid; X is O, NH, NCH3 or Y is OH, NH2, NCH3, N(CH3)2, NHCOCH3 or NHCOCH2COOH; and R9 is a lone pair, H, B(OH)2, a halogen atom, CF3, CCl3, CBr3CH2CF3, CH2CCl3, CH2CBr3, NO2, CO2H, CHCHCOOH, CH2CH2CH2COOH, SO3H, PO3H, OSO3H, OPO3H, OH, NH2, CONH2, COCH3, OCH3, phenyl boronic acid, lower alkyl, or a side chain of a standard amino acid; or a pharmaceutically acceptable salt thereof.