Patent ID: 7153822
Filing Date: 2006-12-26
Classification: A61K,A61P,G01N

Abstract:
1. A method of modulating a hemichannel in a cell, tissue or organ exposed to stress, the method comprising contacting the stressed cell, tissue or organ with a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented as Formula I or II, wherein the contact is sufficient to modulate the hemichannel in the stressed cell, tissue or organ, wherein Formula I is defined as follows: wherein R R R R R and a, S, T, P and Q are integers and independently=0 or 1; and salts thereof, and wherein Formula II is defined as follows: wherein, X1 is 0, Ala, Gly, β-Ala, Tyr, X2 is 0, Ala-Gly-T4c-Pro, Ala-Sar-Hyp-Pro, Ala-Asn, X3 is Tyr, R1 is H or Ac, R2 is OH or NH with the proviso that X1 and X2 are not both 0; and salts thereof.