Patent ID: 7582781
Filing Date: 2009-09-01
Classification: C07B,C07C,C07D

Abstract:
1. A process for producing an optically active epoxy alcohol derivative represented by general formula (14): (wherein Ar 2 represents a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; and each of *5 and *6 represents an asymmetric carbon), in all cases except where R 3 represents hydrogen, the process comprising: subjecting a compound represented by general formula (6): (wherein X 2 represents a halogen atom; R 3 represents hydrogen, a substituted or unsubstituted alkyl group having 1 to 18 carbon atoms, a substituted or unsubstituted aryl group having 6 to 20 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 20 carbon atoms, a substituted or unsubstituted silyl group, a substituted or unsubstituted acyl group having 1 to 20 carbon atoms, or a substituted or unsubstituted heterocycle; Ar 2 is the same as above; and each of *3 and *4 represents an asymmetric carbon) to at least one treatment selected from acid treatment, fluorine compound treatment, and hydrogenolysis to prepare an optically active halo diol derivative represented by general formula (13): (wherein X 2 , Ar 2 , *3, and *4 are the same as above), and then treating the resulting halo diol derivative with a base; or in the case where R 3 represents hydrogen or a substituted or unsubstituted acyl group having 1 to 20 carbon atoms, the process comprising: treating the compound represented by said general formula (6) with a base.