Patent ID: 7498045
Filing Date: 2009-03-03
Classification: A61K,A61P

Abstract:
1. A biodegradable polymeric nanocapsule composition adaptable for use as an artificial red blood cell, said nanocapsule encapsulating an agent of therapeutic interest; wherein said agent of therapeutic interest is cross-linked to the interior surface of the nanocapsule and enhancing in vivo circulation time thereof, said nanocapsule having a bilayer membrane defining an interior surface and an exterior surface and comprising a diblock copolymer consisting of a polylactic acid polymer block and a polyethylene glycol polymer block, wherein said nanocapsule membrane further comprises a lipid component, wherein said diblock copolymer is soluble in acetone and insoluble in water and wherein said polyethylene glycol is present on both the interior surface and the exterior surface of the membrane thereby defining a hydrophilic interior wherein said cross-linked agent of therapeutic interest is present or is entrapped.