Patent ID: 6417228
Filing Date: 2002-07-09
Classification: A61K,C07C

Abstract:
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: wherein:R1=CO2R, CONR4R5, CH2OR6, or CH2NR7R8, where: R=H, alkyl, cationic salt moiety, or CO2R forms a pharmaceutically acceptable ester moiety; R4, R5=same or different=H or alkyl; R6=H, acyl, or alkyl; R7, R8=same or different=H, acyl, or alkyl; with the proviso that if one of R7, R8=acyl, then the other=H or alkyl; n=0 or 2; R2, R3=same or different=H, alkyl, or acyl; â€”â€”â€”=single or non-cumulated double bond; J=O, or H and H; R9=H, alkyl, acyl, or SO2Ar, where Ar=a phenyl ring optionally substituted with hydroxy, acyloxy, alkoxy, alkoxycarbonyl, halo, trihalomethyl, amino, acylamino, or aminoacyl; one of C, D=H, the other=F, OH, acyloxy, or alkoxy; or Câ€”D&boxH;O(CH2)2O or double bonded O; with the proviso that if J=O, then R9=H or alkyl, one of C, D=H, and the other=F, OH, acyloxy, or alkoxy; X=(CH2)q, (CH2)qO, where q=0-6; and Y=a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, alkylamino, acylamino, or OH; or X-Y=(CH2)pY1, where p=0-6, and wherein:W=CH2, O, S(O)m, NR10, CH2CH2, CH&boxH;CH, CH2O, CH2S(O)m, CH&boxH;N, or CH2NR10, where m=0-2; and R10=H, alkyl, or acyl, Z=H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or OH, and â€”â€”â€”=single or double bond.