Patent ID: 8337843
Filing Date: 2012-12-25
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating human metastatic breast cancer, said method comprising administering to a human diagnosed with metastatic breast cancer an anti-EpCAM antibody comprising SEQ ID NOs: 3, 4, 5, 6, 7 and 8, respectively, wherein said subject exhibits high EpCAM expression showing a total immunostaining score for EpCAM of greater than 4, wherein said antibody is administered according to a low dose administration schedule comprising administering at least one loading dose in a range of 1 to 3 mg/kg body weight, followed by multiple maintenance doses, each maintenance dose being in a range of 1 to 3 mg/kg body weight, or a high dose administration schedule comprising administering at least one loading dose in a range of 4.5 to 8 mg/kg body weight, followed by multiple maintenance doses, each maintenance dose being in a range of 4.5 to 8 mg/kg body weight.