Patent ID: 6211162
Filing Date: 2001-04-03
Classification: A01N,A61K,A61P,A61Q,C07H

Abstract:
A method of treating a pulmonary bacterial infection in a mammalian subject, said method comprising the steps of:aerosolizing a formulation to create particles comprising a nucleic acid comprising a backbone structure modified from that of a naturally occurring nucleotide polymer the nucleic acid being protonated to an extent that the nucleic acid exhibits a pH in a range of about 0 to about 5 at a concentration of 1 mg/ml of water and the nucleic acid is characterized by a pH stability of at least one hour at pH about 1 to about 5; andinhaling the aerosolized formulation into lungs of a patient and allowing aerosolized particles of the formulation to deposit on lung tissue.