Patent ID: 6673814
Filing Date: 2004-01-06
Classification: C07D,Y10S

Abstract:
A delivery system for the treatment of neoplastic diseases, comprising a composition comprising a compound of the formula whereinA is and W is C1-6 alkyl; or and forms a six membered ringwith B, said ring containing one nitrogen; Y is (a) C1-6 alkyl, or H; (b) C(O)â€”C1-6 alkyl; wherein Z is C1-6 alkyl or Oâ€”C1-6 alkyl;(d) aryl; or (e) heterocycle; B is a single bond, OH or halo; C is â€”OH, â€”CH2â€”, â€”Oâ€”, or forms a 5-membered lactone or lactam ring with D; and D is: (i) â€”OH, â€”CH2-halo, â€”CH(O), â€”COOH, â€”C(O)â€”Oâ€”C1-6 alkyl, â€”(CH2)nâ€”, â€”CHOHâ€”, wherein n is an integer and is 1, 2, or 3; or (ii) forms a 5-membered lactone or lactam ring with C; E is â€”H or â€”CH3; and F is â€”OH or â€”OCH3, or pharmaceutically acceptable salts thereof, and a controlled-release mechanism for providing prolonged delivery of the composition, whereby the delivery system enhances the delivery of the composition to a patient in need thereof.