Patent ID: 6894049
Filing Date: 2005-05-17
Classification: A61P,C07F

Abstract:
1. A cis-platinum complex of the formula Ia or Ib or a pharmaceutically acceptable salt thereof wherein: each A is independently halo, hydroxy or carboxylate; each B is independently halo, hydroxy, carboxylate, carbamate ester or a carbonate ester; Z of formula Ia is a substituted 5- or 6-membered, heterocyclic amine selected from the group consisting of pyrazole, imidazole and pyrazine, said heterocyclic amine having at least two alkyl substituents, wherein said alkyl substituent sterically hinders access of Pt atom to a DNA strand of a tumor cell, and wherein all substituents on the heterocycle are alkyl substituents; Z of formula Ib is substituted 5- or 6-membered heterocyclic amine having at least two alkyl substituents, wherein said alkyl substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein all substituents on the heterocycle are alkyl substituents; and X is NH