Patent ID: 8216574
Filing Date: 2012-07-10
Classification: A61P,C07K,G01N

Abstract:
1. A modified antibody that binds a CD-20 antigen, said modified antibody comprising a variant human IgG1 Fc region, wherein said variant human IgG1 Fc region comprises at least one amino acid modification relative to the human IgG1 Fc region of a parent antibody that binds said antigen, said amino acid modification(s) comprising amino acid modification(s) that alter the affinity or avidity of the variant Fc region for binding to an FcγR such that said modified antibody is therapeutically effective in a patient refractory to treatment with said parent antibody, said amino acid modification(s) that alter the affinity or avidity of the variant Fc region for binding to an FcγR consisting of the modification of 1, 2, 3, 4 or 5 amino acid residues of the IgG1 Fc region of said parent antibody.