Patent ID: 6610688
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of Formula 1or a pharmaceutically acceptable salt thereof, wherein:R1 is H or methyl; each of R2 and R3 is independently H, halogen, (C1-3)alkyl, or (C1-3)alkoxy; or R2 and R3 taken together form an optionally substituted methylindene selected from the group consisting of: wherein:n is an integer of 0-3; each R7 is independently H, alkyl, carboxylic acid, amine, halogen, nitro, cyano, X1, X2â€”(C1-C4)alkyl-R8, X2-(C2-C4)alkenyl-R8, or X2â€”(C2-C4)alkynyl-R8; X1 is â€”C(O)NR9â€”, â€”NR9C(O)â€”, â€”C(O)Oâ€”, C(O)R11, â€”OC(O)â€”, â€”Oâ€”, â€”NR9â€”, â€”Sâ€”, â€”S(O2), or â€”S(O2)NR9â€”; X2 is a chemical bond, â€”C(O)NR9â€”, â€”NR9C(O)â€”, â€”C(O)Oâ€”, C(O)R11, â€”OC(O)â€”, â€”Oâ€”, â€”NR9â€”, â€”Sâ€”, â€”S(O2), or â€”S(O2)NR9â€”; R8 is selected from the group consisting of hydrogen, dialkylamino, carboxyl, hydoxyl, alkoxy, sulfonamide, urea, carbamate, diol, alkylsulphonyl, and R10; R9 is H or (C1-C3)alkyl; R10 is an optionally substituted 5- or 6-membered saturated, unsaturated, or aromatic heterocycle comprising having from 1 to 4 heteroatoms; and R11 is an optionally substituted 5- to 6-membered saturated heterocyclic ring; or a 3- to 7-membered ring optionally having up to 3 heteroatoms; R4 is H, methyl, trifluoromethyl, (C1-4)alkyl, alkoxy, amido, amino, or optionally substituted aryl; X is a chemical bond, ethynyl, â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”NR5C(O)â€”, or â€”NR5, wherein R5 is H, methyl, or substituted methylene; Y is a 5- to 10-membered mono or bicyclic, saturated, unsaturated, or aromatic ring having up to 3 heteroatoms and optionally substituted; and Z is N.