Patent ID: 6277829
Filing Date: 2001-08-21
Classification: A61K,A61P,Y10S

Abstract:
A process for the preparation of an aqueous azithromycin containing ophthalmic formulation, comprising:dissolving, in an aqueous medium, ophthalmically acceptable polybasic phosphate in an amount ranging from 7.8 to 68.6 g/l and citric acid monohydrate in an amount ranging from 0.9 to 35.94 g/l; andsolubilizing azithromycin in the aqueous medium in an amount ranging from 0.1 to 100 g/l at a temperature of 15 to 25.degree. C. wherein the molar ratio of azithromycin to citric acid ranges from 1:0.67 to 1:1.5, the pH is adjusted to range from 5.5 to 7.6 and the final osmolality ranges from 130 to 300 mOsm/kg.