Patent ID: 9096612
Filing Date: 2015-08-04
Classification: A61P,C07D

Abstract:
1. A method of treating age-related cognitive decline mediated by the S1P signaling pathway, the method comprising administering to a patient in need thereof a compound of formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, or an N-oxide of any of the foregoing: wherein R1 is selected from the group consisting of: Z is a —W—(C R2 is selected from H and at least one substituent independently selected from cyano, halogen, (1-4C)alkyl optionally substituted with at least one halogen atom, and (1-4C)alkoxy optionally substituted with at least one halogen atom; ring structure A optionally contains a nitrogen atom; X is selected from the group consisting of C and N; Y is selected from the group consisting of NH, O, and S; Structure Q is selected from the group consisting of a 5-, 6- and 7-membered cyclic amine; and R4 is selected from the group consisting of: