Patent ID: 7057051
Filing Date: 2006-06-06
Classification: A61P,C07D

Abstract:
1. A compound selected from: (1) benzyl 4,5-diphenyl-1-methylimidazole-2-carboxylate, (2) benzyl 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylate, (3) ethyl 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylate, (4) N-phenyl-4,5-diphenyl-1-methylimidazole-2-carboxamide, (5) N-hexyl-4,5-diphenyl-1-methylimidazole-2-carboxamide, (6) N-cyclohexyl-4,5-diphenyl-1-methylimidazole-2-carboxamide, (7) N-benzyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (8) N-phenyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (9) N-hexyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (10) N-t-butyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (11) N-cyclohexyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (12) N-propyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (13) N-methyl-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide, (14) benzyl 4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxylate, (15) N-(hexyl)-4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (16) N-(t-butyl)-4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (17) N-(cyclohexyl)-4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (18) N-(cyclohexyl)-4,5-di-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide, (19) N-(cyclohexyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide, (20) N-(hexyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide, (21) N-(t-butyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide, (22) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (23) N-(cycloheptyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (24) N-(cyclopentyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (25) N-(phenyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (26) N-(cyclohexyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-ethylimidazole-2-carboxamide, (27) N-(hexyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-ethylimidazole-2-carboxamide, (28) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-ethylimidazole-2-carboxamide, (29) cyclohexyl 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate, (30) N-methyl-N-cyclohexyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate, (31) N-ethyl 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate, (32) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-ethylimidazole-2-carboxamide, (33) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-(1-methyl)ethyl-imidazole-2carboxamide, (34) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-(1,1-dimethyl)ethyl-imidazole-2-carboxamide, (35) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-(2-dimethylamino)ethylimidazole-2-carboxamide, (36) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-butylimidazole-2-carboxamide, (37) N-(cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-(2-methoxy)ethylimidazole-2-carboxamide, (38) N-(pentyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (39) N-(1-ethylpropyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (40) N-(1-methylethyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (41) N-(3-cyclohexenyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (42) N-((2-trans-hydroxymethyl)cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (43) N-((2-cis-hydroxymethyl)cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (44) N-((2-trans-hydroxy)cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (45) N-((2-cis-hydroxy)cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (46) N-((4-trans-hydroxy)cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (47) N-(4-methyl-cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide (Isomer A), (48) N-(4-methyl-cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide (Isomer B), (49) N-(1-fluoro-cyclohexen-4-yl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (50) N-(4,4-difluoro-cyclohexyl)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, (51) 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxamide, and pharmaceutically acceptable salts thereof.