Patent ID: 6316259
Filing Date: 2001-11-13
Classification: A61K,A61P,C12N,C12Y,Y02P

Abstract:
An antisense compound 8 to 30 nucleobases in length targeted to nucleotides 3 through 22 of a 5' untranslated region, nucleotides 84 through 110 of a start codon, nucleotides 230 through 249, nucleotides 307 through 326, nucleotides 353 through 394, nucleotides 410 through 464, nucleotides 491 through 510, nucleotides 518 through 537, nucleotides 565 through 592, nucleotides 617 through 651, nucleotides 665 through 684, nucleotides 706 through 725, nucleotides 782 through 801, nucleotides 840 through 878, nucleotides 887 through 909, nucleotides 960 through 985, nucleotides 1058 through 1077, nucleotides 1309 through 1328, or nucleotides 1491 through 1510 of a coding region, nucleotides 1708 through 1729, nucleotides 1747 through 1774, nucleotides 1936 through 1973, nucleotides 2064 through 2083, or nucleotides 2116 through 2135 of a 3' untranslated region of human glycogen synthase kinase 3 alpha (SID. NO:3), or to nucleotides 1191 through 1210, nucleotides 1309 through 1328, nucleotides 2646 through 2665, nucleotides 2938 through 2957, nucleotides 3241 through 3260, nucleotides 3504 through 3523, nucleotides 4021 through 4040, nucleotides 5633 through 5652, nucleotides 5788 through 5807, nucleotides 6647 through 6666, nucleotides 7056 through 7075, nucleotides 7190 through 7209, nucleotides 7312 through 7331, nucleotides 7823 through 7842, nucleotides 8748 through 8767, nucleotides 8967 through 8986, nucleotides 9827 through 9846, nucleotides 10612 through 10631, nucleotides 10669 through 10688, or nucleotides 11332 through 11351 of an intron of human glycogen synthase kinase 3 alpha (SID. NO:10), wherein said antisense compound specifically hybridizes with and inhibits the expression of human glycogen synthase kinase 3 alpha mRNA.