Patent ID: 7790680
Filing Date: 2010-09-07
Classification: A61K,A61P

Abstract:
1. A solid pharmaceutical composition comprising a lyophilized solution devoid of amino acids, wherein said solution comprises: (a) mature recombinant porcine factor VIII, wherein said mature recombinant porcine factor VIII extends from amino acid residue 20 to amino acid residue 1467 of; (b) a surfactant; (c) calcium chloride; (d) sucrose; (e) sodium chloride; (f) trisodium citrate; and (g) a buffer devoid of amino acids; wherein said solution has a pH from 6 to 8 prior to lyophilization and wherein said solid pharmaceutical composition results in a solution having a pH from 6 to 8 after reconstitution in water for injection.