Patent ID: 7820400
Filing Date: 2010-10-26
Classification: A61P,C07K,C12N,G01N

Abstract:
1. A method for diagnosing a breast cancer in a subject by detecting TIP-2 antigen-bearing cancer cells which comprises: (a) obtaining a sample of the subject's peripheral blood; (b) contacting the sample with an antibody directed to an epitope on TIP-2 antigen or a Fab fragment of such an antibody, wherein the epitope is recognized by the antibody or Fab fragment, and the antibody or Fab fragment is detectably labeled, under appropriate conditions so as to produce an antibody-TIP-2 antigen complex or a Fab fragment-TIP-2 antigen complex comprising the detectably labeled antibody or Fab fragment bound to any TIP-2 antigen bearing breast cancer cells in the sample; (c) removing any labeled antibody or Fab fragment not in the antibody-TIP-2 antigen complex or Fab fragment-TIP-2 antigen complex formed in step (b); and (d) determining the presence of any antibody-TIP-2 antigen complex or any Fab fragment-TIP-2 antigen complex by detecting the detectably labeled antibody or Fab fragment, the presence of antibody-TIP-2 antigen complex or Fab fragment-TIP-2 antigen complex being diagnostic of breast cancer so as to thereby diagnose breast cancer in the subject.