Patent ID: 8933105
Filing Date: 2015-01-13
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula (I) wherein R 1 is a pyridyl group which may optionally be substituted by 1 to 5 substituents selected from (1) a halogen atom, (2) nitro, (3) cyano, (4) hydroxy, (5) C 1-6 alkoxy optionally having 1 to 5 halogen atoms, (6) C 6-14 aryloxy, (7) C 7-16 aralkyloxy, (8) mercapto, (9) C 1-6 alkylthio optionally having 1 to 5 halogen atoms, (10) C 6-14 arylthio, (11) C 7-16 aralkylthio, (12) amino, (13) mono-C 1-6 alkylamino, (14) mono-C 6-14 arylamino, (15) mono-C 7-16 aralkylamino, (16) di-C 1-6 alkylamino, (17) di-C 6-14 arylamino, (18) di-C 7-16 aralkylamino, (19) formyl, (20) C 1-6 alkyl-carbonyl, (21) C 6-14 aryl-carbonyl, (22) carboxyl, (23) C 1-6 alkoxy-carbonyl, (24) C 6-14 aryloxy-carbonyl, (25) carbamoyl, (26) thiocarbamoyl, (27) mono-C 1-6 alkyl-carbamoyl optionally substituted by hydroxyl, (28) di-C 1-6 alkyl-carbamoyl, (29) C 6-14 aryl-carbamoyl, (30) C 1-6 alkylsulfonyl, (31) C 6-14 arylsulfonyl, (32) C 1-6 alkylsulfinyl, (33) C 6-14 arylsulfinyl, (34) formylamino, (35) C 1-6 alkyl-carbonylamino, (36) C 6-14 aryl-carbonylamino, (37) C 1-6 alkoxy-carbonylamino, (38) C 1-6 alkylsulfonylamino, (39) C 6-14 arylsulfonylamino, (40) C 1-6 alkyl-carbonyloxy, (41) C 6-14 aryl-carbonyloxy, (42) C 1-6 alkoxy-carbonyloxy, (43) mono-C 1-6 alkyl-carbamoyloxy, (44) di-C 1-6 alkyl-carbamoyloxy, (45) C 6-14 aryl-carbamoyloxy, (46) C 1-3 alkylenedioxy, (47) C 3-7 cycloalkyl, (48) a C 1-6 alkyl group optionally having 1 to 5 halogen atoms or hydroxy, (49) a C 2-6 alkenyl group optionally having 1 to 5 halogen atoms, (50) C 2-6 alkynyl group, (51) a C 6-14 aryl group optionally having 1 to 5 halogen atoms, (52) C 7-16 aralkyl optionally having 1 to 5 halogen atoms, and (53) oxo, R R provided that 1-[5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine, 1-[5-(2-chloropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine, 1-{5-(2-fluoropyridin-3-yl)-1-[(6-methoxypyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl}-N-methylmethanamine, N-methyl-1-[5-(2-methylpyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methanamine, 1-{5-(2-fluoropyridin-3-yl)-1-[(6-methylpyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl}-N-methylmethanamine, and 1-[4-chloro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine are excluded, or a salt thereof.