Patent ID: 6500466
Filing Date: 2002-12-31
Classification: A61K,A61P

Abstract:
A storage-stable powdered chlorhexidine base formulation comprising:a water soluble mixture of chlorhexidine base and one or more sugar acids or lactones of sugar acids, the one or more sugar acids being selected from the group consisting of gluconic acid, gluconolactone, lactobionic acid (I), D-galactono-&ggr;-lactone (II), L-mannono-&ggr;-lactone (III), D-(âˆ’)-gulono-&ggr;-lactone (IV), D-(+)-galacturonic acid (V) and &agr;-D-heptaglucono-&ggr;-lactone (VI), wherein the molar ratio of chlorhexidine base to sugar acid or lactone of a sugar acid is 1 to greater than or equal to 2; less than 0.05% free water; and 0 to 10 wt. % of auxiliary substances; wherein the storage-stable, powdered chlorhexidine formulation comprises less than 500 ppm p-chloroaniline after 250 days in storage.