Patent ID: 6387350
Filing Date: 2002-05-14
Classification: A61K,B82Y

Abstract:
A method of close-range detection of lesions during an endoscopic, laparoscopic, intravascular catheter, or surgical procedure, wherein the method comprises:(a) injecting a patient who is to undergo such a procedure with a bispecific antibody F(ab)2 or F(abâ€²)2 fragment, wherein the bispecific antibody fragment has a first antibody binding site which specifically binds to an antigen produced or associated with a lesion, and has a second antibody binding site which specifically binds to a hapten, and permitting the antibody fragment to accrete at target sites; (b) clearing non-targeted antibody fragments by injecting an amount of a galactosylated anti-idiotype clearing agent sufficient to effect rapid clearance from circulation within about 24 hours of injection, and injecting a bivalent labeled hapten, which quickly localizes at the target site and clears through the kidneys; and (c) detecting the presence of the hapten by close-range detection of elevated levels of accreted label at the target sites with detection means, within 48 hours of the first injection, and conducting said procedure.