Patent ID: 6387928
Filing Date: 2002-05-14
Classification: C07D

Abstract:
A compound having the following formula: wherein:(a) X is selected from the group consisting of (b) R1 is selected from the group consisting of C3 to about C5 cycloalkyl, C1 to about C2 alkanyl, C2 to about C3 linear alkenyl, C3 to about C4 branched alkanyl or alkenyl, all such alkyl or cycloalkyl moieties being unsubstituted or substituted with from 1 to about 3 fluoro; and phenyl, unsubstituted or substituted with from 1 to about 3 fluoro, or with one hydroxy in the 4-position; (c) R3 is hydrogen or hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C1 to about C2 alkanyl, C2 alkenyl, and methoxy, all such alkyl and methoxy moieties being unsubstituted or substituted with from 1 to about 3 fluoro; (e) R8 is selected from the group consisting of fluoro, chloro and bromo; (f) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C1 to about C3 alkanyl; or aminoalkanyl which is attached to any ring carbon of X and is C1 to about C3 alkanyl substituted with one amino, the amino being unsubstituted or substituted with one or two C1 to about C3 alkanyl; (g) each R9 is independently selected from the group consisting of hydrogen, C1 to about C4 alkanyl, C2 to about C6 alkenyl or alkynyl, and a C3 to about C6 fused or spirocycle alkyl ring; or one R9 may optionally be selected front the group consisting of hydroxy, C1 to about C4 alkoxy, aryl and heteroaryl, all other R9 being hydrogen; all alkyl and aryl portions of R9 moieties being unsubstituted or substituted with one hydroxy or with from 1 to about 3 fluoro; and (h) a R7 moiety described in (f) and a R9 moiety described in (g) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to about 5 ring carbons and 0 or 1 ring nitrogen; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.