Patent ID: 6432675
Filing Date: 2002-08-13
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of producing a set of polypeptides having amino acid sequences derived from a population of variants of a pathogen protein, or antigenic portion thereof, comprising the steps of:a. selecting a protein of a pathogen, or antigenic portion thereof, which exhibits a population of variants; b. determining the number of times each type of amino acid occurs at each amino acid position in the variants; c. calculating the frequency of occurrence of each type of amino acid at each amino acid position in the variants; d. synthesizing a set of polypeptides wherein the set of polypeptides consists of polypeptides wherein each amino acid at each position of the polypeptide occurs in greater than a selected frequency when compared to the corresponding amino acids of all of the variants, each polypeptide within the set being from 8 to 150 amino acids in length; and e. collecting the set of polypeptides following synthesis.