Patent ID: 9089604
Filing Date: 2015-07-28
Classification: A61K,A61P,C07H,C07K,C12N,C12P,C12Y,Y02A

Abstract:
1. A method of producing a polypeptide of interest in a mammalian cell or tissue comprising contacting said mammalian cell or tissue with an mRNA having a 3′ untranslated region and a 5′ untranslated region, wherein said modified mRNA encodes a member selected from the group consisting of galactosylceramidase (SEQ ID NO: 47205), galactosylceramidase (SEQ ID NO: 47206), galactosylceramidase (SEQ ID NO: 47207), galactosylceramidase (SEQ ID NO: 47208) and galactosylceramidase (SEQ ID NO: 47209), and wherein said mRNA comprises a coding region, said coding region having at least 85% identity to SEQ ID NO: 82603.