Patent ID: 8623379
Filing Date: 2014-01-07
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of eliciting a cellular and humoral immune response to an HIV antigen in a human subject comprising: (a) administering to the human subject a composition comprising a DNA vector encoding at least: HIV Gag, HIV Pol lacking the integrase domain, HIV Tat, HIV Rev, HIV Vpu, and HIV Env, all of which are of a selected HIV chosen from the group consisting of HIV clades A, B, C, D, E, F, G, H, I, J, K, L, and HIV AG, wherein the DNA vector comprises: nucleotides 6,627-9,506 of SEQ ID NO:8 or nucleotides 6,643-10,466 of SEQ ID NO:14; and (b) administering to the subject a composition comprising a modified vaccinia Ankara virus expressing at least one HIV antigen, wherein a cellular and humoral immune response to an HIV antigen is elicited in the human subject.