Patent ID: 6087365
Filing Date: 2000-07-11
Classification: A61P,C07C,C07D,Y02A

Abstract:
A method of treatment for drug-resistant malaria comprising administering to a mammal in need thereof a therapeutically effective amount of a compound or salt represented by the formula: ##STR9## wherein: A is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHR.sup.2 --CH.sub.2 -- or --CH.sub.2 --CHR.sup.a --CHR.sup.b --CH.sub.2 -- where one of R.sup.a or R.sup.b is H, OH lower acyloxy, and the other is H;R.sup.1 is H, F, Cl or Br;R.sup.2 is H, F, Cl or Br; andR.sup.3 is heteroaryl or optionally substituted phenyl where the substituents are selected from F, Cl, Br, CF.sub.3, CN, NO.sub.2 and OCHF.sub.2 ;or a pharmaceutically acceptable salt thereof.