Patent ID: 6518043
Filing Date: 2003-02-11
Classification: A61K,A61P,C07K

Abstract:
An isolated polypeptide selected from the group consisting of:(a) a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:3; (b) a polypeptide comprising a derivative of the amino acid sequence set forth in SEQ ID NO:3, in which one or more amino acids are substituted, deleted, inserted, and/or added, wherein said derivative amino acid sequence has a 80% or more sequence identity with the amino acid sequence set forth in SEQ ID NO:3; and (c) a polypeptide endoded by a DNA hybridizing with the DNA comprising the nucleotide sequence as set forth in SEQ ID NO:1, wherein hybridization is done at 42Â° C. overnight in a hybridization solution containing 25% formamide, 4Ã—SSC, 50 mM Hepes pH 7.0 and 10Ã—Denhardt's solution and 20 &mgr;g/ml denatured salmon sperm DNA and a labeled probe, followed by successive washings at room temperature with 2Ã—SSC and 0.1% SDS, wherein said polypeptide suppresses the proliferation of lympho-hematopoietic cells.