Patent ID: 6828343
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound of formula I: a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug, wherein Q is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; each Z and X are independently (C, CH or CH2), N, O or S; X1 is NRa, â€”CH2â€”, O or S; each - - - - is independently a bond or is absent, provided that both - - - - are not simultaneously bonds; R1 is hydrogen, halogen, â€”OC1-C8alkyl, â€”SC1-C8alkyl, â€”C1-C8alkyl, â€”CF3, â€”NH2, â€”NHC1-C8alkyl, â€”N(C1-C8alkyl)2, â€”NO2, â€”CN, â€”CO2H, â€”CO2C1-C8alkyl, â€”C2-C8alkenyl, or â€”C2-C8akynyl; each Ra and Rb is independently hydrogen or â€”C1-C8alkyl; Y is â€ƒor absert; R2 and R3 together with the atoms on the ring to which they are attached form a five or six membered ring consisting of from 0 to 3 heteroatoms and from 0 to 2 double bonds; R4 is â€”C(&boxH;O)-A; A is â€”NRdRd, â€”NRaCH2CH2ORa, each Rd is independently hydrogen, C1-C8alkyl, C1-C8alkoxy, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; each Rc is independently hydrogen, â€”C(&boxH;O)ORa, â€”ORa, â€”SRa, or â€”NRaRa; and each n is independently 1-3.