Patent ID: 6048873
Filing Date: 2000-04-11
Classification: A61P,C07D

Abstract:
A compound of Formula 1 ##STR11## where Y is a bivalent radical having Formula 3 ##STR12## the two X.sub.1 groups jointly represent an oxo (.dbd.O) or thione (.dbd.S) function, or X.sub.1 is independently selected from H or alkyl of 1 to 6 carbons;the two X.sub.2 groups jointly represent an oxo (.dbd.O) or a thione (.dbd.S) function, or X.sub.2 is independently selected from H or alkyl of 1 to 6 carbons, with the proviso that one of the joint X.sub.1 grouping or of the joint X.sub.2 grouping represents an oxo (.dbd.O) or a thione (.dbd.S) function;W is O, C(R.sub.1).sub.2, or W does not exist;R.sub.1 is independently H, lower alkyl of 1 to 6 carbons, or lower fluoroalkyl of 1 to 6 carbons;R.sub.2 is independently H, lower alkyl of 1 to 6 carbons, or lower fluoroalkyl of 1 to 6 carbons;R.sub.3 is hydrogen, lower alkyl of I to 6 carbons, OR.sub.1, fluoro substituted lower alkyl of 1 to 6 carbons or halogen, NO.sub.2, NH.sub.2, NHCO(C.sub.1 -C.sub.6 alkyl, or NHCO(C.sub.1 -C.sub.6)alkenyl;A is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CH(OR.sub.13 O), --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 (OR.sub.13 O), or Si(C.sub.1-6 alkyl).sub.3, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons or (trimethylsilyl)alkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl, hydroxyphenyl or lower alkylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons, andR.sub.14 is H, alkyl of 1 to 10 carbons, fluoro-substituted alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons and having 1 to 3 double bonds.