Patent ID: 6310083
Filing Date: 2001-10-30
Classification: C07C,Y02P

Abstract:
A compound represented by structural Formulae (I), (II), (IV), (V), (VI) or (VII): ##STR6##wherein R.sup.1 and R.sup.2, which may be the same or different, are each selected from the group consisting of H, Li, Na, K, Cs, an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, and --CH.sub.2 O.sub.2 C--R.sup.1a, wherein R.sup.1a is an alkyl group having from 1 to 5 carbon atoms; additionally R.sup.2 is selected from the group consisting of 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl, 2-nitrophenyl, 4-nitrophenyl, pentachlorophenyl, pentafluorophenyl, and N-succinimidyl;wherein R.sup.3 is selected from the group consisting of H, an alkyl group having from 1 to 5 carbon atoms, CH.sub.3 --S--(CH.sub.2).sub.2 --, benzyl, and --(CH.sub.2).sub.n --(CO)--Y, wherein n is an integer of from 1 to 5 and Y is OR.sup.3a or NR.sup.3b R.sup.3c, wherein R.sup.3a, R.sup.3b and R.sup.3c, which may be the same or different, are each selected from the group consisting of H and an alkyl group having from 1 to 5 carbon atoms, and R.sup.3a may additionally be selected from the group consisting of Li, Na, K and Cs;wherein R.sup.4 and R.sup.5, which may be the same or different, are each selected from the group consisting of H, an alkyl group having from 1 to 5 carbon atoms, F, Cl, Br, CN, NO.sub.2, CO.sub.2 R.sup.4a, OR.sup.4a, wherein R.sup.4a is selected from the group consisting of H, Li, Na, K, Cs, an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, and --CH.sub.2 O.sub.2 --R.sup.4b, wherein R.sup.4b is an alkyl group having from 1 to 5 carbon atoms; and wherein optionally, R.sup.4 and R.sup.5 together from a methylenedioxy (O--CH.sub.2 --O) linkage; ##STR7##wherein R.sup.6 is selected from the group consisting of H, t-utyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz), 9-luorenylmethyloxycarbonyl (Fmoc), and a group represented by structural Formula (III);wherein R.sup.7 is selected from the group consisting of H, Li, Na, K, Cs, an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl, 2-nitrophenyl, 4-nitrophenyl, pentachlorophenyl, pentafluorophenyl, and N-succinimidyl, and --CH.sub.2 O.sub.2 C--R.sup.7a, wherein R.sup.7a is an alkyl group having from 1 to 5 carbon atoms;wherein R.sup.8 is selected from the group consisting of --(CH.sub.2-p (CH.sub.3).sub.p)--Y--R.sup.8a, --(CH.sub.2-p (CH.sub.3).sub.p)--C.sub.6 H.sub.4 --Y--R.sup.8a, wherein p is 0, 1, or 2, Y is O or S, wherein R.sup.8a is a group represented by structural Formula (III), and --(CH.sub.2).sub.q --Z, wherein q is 3 or 4, and Z is --NH--R.sup.8b or --NH--C(.dbd.NH)--NH--R.sup.8b, wherein R.sup.8b is a group represented by structural Formula (III); ##STR8##wherein R.sup.9 is selected from the group consisting of H, Li, Na, K, Cs, an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, and --CH.sub.2 O.sub.2 C--R.sup.9a, wherein R.sup.9a is an alkyl group having from 1 to 5 carbon atoms;wherein R.sup.10 and R.sup.11, which may be the same or different, are each selected from the group consisting of H, an alkyl group having 1 to 5 carbon atoms, F, Cl, Br, CN, NO.sub.2, CO.sub.2 R.sup.10a, and OR.sup.10a, wherein R.sup.10a is selected from the group consisting of H, Li, Na, K, Cs, an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, and --CH.sub.2 O.sub.2 C--R.sup.10b, wherein R.sup.10b is an alkyl group having from 1 to 5 carbon atoms; and wherein optionally, R.sup.10 and R.sup.11 together from a methylenedioxy (O--CH.sub.2 --O) linkage; ##STR9## ##STR10##wherein R.sup.12 is selected from the group consisting of H, t-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz), 9-fluorenylmethyloxycarbonyl (Fmoc), and a group represented by structural Formula (III);wherein R.sup.13 is selected from the group consisting of H, Li, Na, K, Cs and an alkyl group having from 1 to 5 carbon atoms, NH.sub.4, 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl, 2-nitrophenyl, 4-nitrophenyl, pentachlorophenyl, pentafluorophenyl, and N-succinimidyl, and --CH.sub.2 O.sub.2 C--R.sup.13a, wherein R.sup.13a, is an alkyl group having from 1 to 5 carbon atoms; andwherein R.sup.14 is a group represented by structural Formula (III).