Patent ID: 8603534
Filing Date: 2013-12-10
Classification: A61J,A61K,A61P,B82Y,C07C,Y10S

Abstract:
1. A therapeutic nanoparticle comprising: about 4 to about 25 weight percent of an anti-cancer agent, wherein the anti-cancer agent is a kinase inhibitor; about 10 to about 99 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer, wherein said poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic acid) having a number average molecular weight of about 15 to 20 kDa and poly(ethylene)glycol having a number average molecular weight of about 4 to about 6 kDa; and wherein the hydrodynamic diameter of the therapeutic nanoparticle is about 60 to about 140 nm; and wherein the therapeutic nanoparticle releases less than 10% of the anti-cancer agent over about one minute when placed in a phosphate buffer solution at 37° C.