Patent ID: 7563457
Filing Date: 2009-07-21
Classification: A61K,B82Y,C12Q,Y10S,Y10T

Abstract:
1. A nanoparticle-containing microsphere comprising: a. A diblock copolymer, acting as structure directing agent, that binds to a first and second type of nanoparticles; b. the structure of the agent being such to direct the formation of an inner and outer layer of said microsphere; c. said inner layer of said microsphere comprising a first type of nanoparticles bound to the cysteine residues of the structure directing agent; and d. said outer layer of said microsphere coating the inner layer comprising a second type of nanoparticles bound to the positively charged residues of the structure-directing agent; e. wherein the first type of nanoparticles is selected from the group consisting of semiconductor group II-VI metal non-oxide nanocrystals, gold nanoparticles, silver nanoparticles, platinum nanoparticles, palladium nanoparticles, copper nanoparticles, rhodium nanoparticles, rhenium nanoparticles, nickel nanoparticles, and iridium nanoparticles and primary functionalization thereof to introduce therapeutic or imaging agents; and f. wherein the second type of nanoparticles is selected from the group consisting of silicon oxide, titanium oxide; aluminum oxide, zirconium oxide, magnesium oxide and-secondary functionalization thereof to introduce a recognition element for in vivo targeting.