Patent ID: 9221908
Filing Date: 2015-12-29
Classification: A61K,C07K

Abstract:
1. A monoclonal antibody, or antigen-binding fragment thereof, that specifically binds CD47, wherein the monoclonal antibody, or antigen-binding fragment thereof, comprises three light chain complementarity determining regions (LCDRs 1-3) and three heavy chain complementarity determining regions (HCDRs 1-3), wherein: LCDR 1 comprises the amino acid sequence RSSQSLVHSNGNTYLH (SEQ ID NO:1); LCDR 2 comprises the amino acid sequence KVSYRFS (SEQ ID NO:2); and LCDR 3 comprises the amino acid sequence SQNTHVPRT (SEQ ID NO:3); HCDR 1 comprises the amino acid sequence GYTFTNYYVF (SEQ ID NO:4); HCDR 2 comprises the amino acid sequence DINPVNGDTNFNEKFKN (SEQ ID NO:5); and HCDR 3 comprises the amino acid sequence GGYTMDY(SEQ ID NO:6).