Patent ID: 9132099
Filing Date: 2015-09-15
Classification: A61B,A61K,A61L,A61P

Abstract:
1. A method of treating a site of vascular compromise in a target vessel to seal a puncture or opening, and treat, suppress or prevent a tissue response at such site resulting from the sealing of the puncture or opening, comprising the steps of: combining a tissue response regulating amount of rapamycin and a hemostatic material comprising a sheet of collagen, wherein the sheet of collagen is either impregnated, absorbed, adsorbed, saturated, dispersed or immobilized with rapamycin in an amount of about 0.2 μg/cm applying the combination perivascularly to the target vessel at the site of vascular compromise such that the combination is placed over and around an outer circumferential surface of the target vessel, seals the puncture or opening, and elutes the rapamycin to the target vessel over the substantial length of the hemostatic device.