Patent ID: 6670341
Filing Date: 2003-12-30
Classification: A61K,A61P,C07F,C07H,Y02A

Abstract:
A compound having the structure of Formula I: wherein,n and m are each independently 0 or 1, but n and m are not both 0; R1 is (C1-C16)alkyl, branched alkyl, alkenyl or alkynyl if n is 0 and (C1-C16)alkylene, branched alkyl, alkenyl or alkynyl if n is 1; R2 is (C1-C16)alkyl, branched alkyl, alkenyl or alkynyl if m is 0 and (C1-C16) alkylene, branched alkyl, alkenyl or alkynyl if m is 1; R3, R4 and R5 are each independently (C1-C8)alkylene; R6, R7 and R8 are each independently (C1-C8)alkyl; X1 and X2 are each independently S, O, NHC&boxH;O, OC&boxH;O or NH; X3 is O or S; E1 is H, S, halo or N3; Z1 is H, S, or halo; or E1 and Z1 together are a covalent bond; E2 is H, S, halo, or N3; Z2 is H, S, or halo; or E2 and Z2 together are a covalent bond; D1 and D2 are each independently selected from the group consisting of purine, pyrimidine, adenine, thymine, cytosine, guanine, hypoxanthine, inosine, uracil and ring modifications thereof, including O, N, and S substitutions, and wherein, each alkyl, alkylene, branched alkyl, alkenyl, alkynyl, adenine, thymine, cytosine, guanine, pyrimidine, purine, hypoxanthine, inosine and uracil of R1, R2, R3, R4, R5, R6,R7, R8, D1, and D2 can, optionally, be substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of halo, nitro, trifluoromethyl, (C1-C8)alkyl, (C1-C8)alkoxy, aryl, and N(Ra)(Rb) wherein Ra and Rb are each independently selected from the group consisting of H and (C1-C8)alkyl.