Patent ID: 6562942
Filing Date: 2003-05-13
Classification: A61K,C07K

Abstract:
A peptide analogue comprising amino acid residues 9 to 23 of human insulin B chain wherein the peptide analogue differs in sequence from native human insulin B chain residues 9 to 23 due to amino acid alanine substitutions of 1, 2, 3 or 4 amino acid residues within the residues 9 to 23 of human insulin B chain, wherein at least one substitution occurs at a residue selected from the group consisting of residues 12, 13, 15 and 16 of SEQ ID NO:1, wherein the peptide analogue comprises no more than 18 residues of human insulin B chain, and wherein the peptide analogue is capable of reducing incidence of diabetes in non-obese diabetic (NOD) mice.