Patent ID: 9144629
Filing Date: 2015-09-29
Classification: A61L

Abstract:
1. A method for preparing a collagen bioglass ionically cross-linked composite, comprising: mixing water or an ion-containing solution of divalent or polyvalent metal ions with the collagen and bioactive glass having an average pore size of at least 100 microns for a time sufficient to cross-link collagen and to form a paste, wherein the mixture comprises from 60 wt. % to 98 wt. % of bioactive glass, and the collagen is crosslinked by the bioactive glass or divalent or polyvalent metal ions; and freeze-drying the paste to form the collagen bioactive glass ionically cross-linked composite, wherein the method does not utilize chitosan or an organic crosslinking agent; and wherein the paste is free of calcium phosphate.