Patent ID: 6503901
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein:Q is C1-C6 alkyl substituted with 0-3 R1a; C3-C10 cycloalkyl substituted with 0-3 R1b; C3-C10 carbocycle substituted with 0-3 R1b; aryl substituted with 0-3 R1b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b; R1a, at each occurrence, is independently selected from H, R1b, Cl, F, Br, I, OR14, CN, NO2, &boxH;O, NR19R20, CF3, C1-C4 alkyl; C2-C4 alkenyl; C2-C4 alkynyl; C1-C4 haloalkyl; C1-C4 haloalkoxy; C3-C10 carbocycle substituted with 0-3 R1b; aryl substituted with 0-3 R1b; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b; R1b, at each occurrence, is independently selected from H, OR14, Cl, F, Br, I, CN, NO2, &boxH;O, NR19R20, CF3, OCF3, C1-C4 alkoxy, C1-C4 haloalkoxy; â€”C(&boxH;O) R1d, â€”Oâ€”R1d, â€”Sâ€”R1d, â€”S(&boxH;O)â€”R1d, â€”S(&boxH;O)2â€”R1d, â€”N(R19)â€”R1d, â€”C(&boxH;O)NR19bR1d, â€”NR19bC(&boxH;O)â€”R1d, â€”NR19bS(&boxH;O)2â€”R1d, â€”S(&boxH;O)2NR19bâ€”R1d, â€”NR19bS(&boxH;O)â€”R1d, â€”S(&boxH;O)NR19bâ€”R1d, â€”C(&boxH;O)Oâ€”R1d, â€”OC(&boxH;O)â€”R1d; C1-C6 alkyl substituted with 0-3 R1c; C2-C6 alkenyl substituted with 0-2 R1c; C2-C6 alkynyl substituted with 0-2 R1c; C3-C10 cycloalkyl substituted with 0-3 R1f; C3-C10 carbocycle substituted with 0-3 R1f; aryl substituted with 0-3 R1f; and 5 to 14 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 14 membered heterocycle is substituted with 0-3 R1f; R1c, at each occurrence, is independently selected from H, OR14, Cl, F, Br, I, CN, NO2, NR19R20, CF3, C1-C4 alkoxy, C1-C4 haloalkoxy; â€”C(&boxH;O)â€”R1d, â€”Oâ€”R1d, â€”Sâ€”R1d, â€”S(&boxH;O)â€”R1d, â€”S(&boxH;O)2â€”R1d, â€”N(R19)â€”R1d, â€”C(&boxH;O)NR19bR1d, â€”NR19bC(&boxH;O)â€”R1d, â€”NR19bS(&boxH;O)2â€”R1d, â€”S(&boxH;O)2NR19bâ€”R1d, â€”NR19bS(&boxH;O)â€”R1d, â€”S(&boxH;O)NR19bâ€”R1d, â€”C(&boxH;O)Oâ€”R1d, â€”OC(&boxH;O)â€”R1d; C3-C10 cycloalkyl substituted with 0-3 R1f; C3-C10 carbocycle substituted with 0-3 R1f; aryl substituted with 0-3 R1f; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1f; R1d, at each occurrence, is independently selected from H, C1-C6 alkyl substituted with 0-3 R1e; C2-C6 alkenyl substituted with 0-2 R1e; C2-C6 alkynyl substituted with 0-2 R1e; C3-C10 cycloalkyl substituted with 0-3 R1f; C3-C10 carbocycle substituted with 0-3 R1f; aryl substituted with 0-3 R1f; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1f; R1e, at each occurrence, is independently selected from H, OR14, Cl, F, Br, I, CN, NO2, &boxH;O, NR19R20, CF3, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy; C3-C10 cycloalkyl substituted with 0-3 R1f; C3-C10 carbocycle substituted with 0-3 R1f; aryl substituted with 0-3 R1f; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1f; R1f, at each occurrence, is independently selected from H, OR14, SR14, Cl, F, Br, I, CN, NO2, &boxH;O, NR19R20, CF3, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R2 is H, C1-C6 alkyl, (C1-C6 alkoxy) C1-C3 alkyl, C3-C6 carbocycle, aryl, (C3-C6 carbocycle)methyl, (aryl)methyl, (aryl)ethyl, or 5 to 10 membered heterocycle; R5 is H, OR14; C1-C6 alkyl substituted with 0-3 R5b; C1-C6 alkoxy substituted with 0-3 R5b; C2-C6 alkenyl substituted with 0-3 R5b; C2-C6 alkynyl substituted with 0-3 R5b; C3-C10 cycloalkyl substituted with 0-3 R5c; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c; R5a is H or C1-C4 alkyl; R5b, at each occurrence, is independently selected from: H, C1-C6 alkyl, CF3, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16; acetyl, â€”S(C1-C4 alkyl), â€”S(&boxH;O)(C1-C4 alkyl), â€”S(&boxH;O)2(C1-C4 alkyl); C3-C10 cycloalkyl substituted with 0-3 R5c; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c; R5c, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R6 is H; C1-C6 alkyl substituted with 0-3 R6a; C3-C10 carbocycle substituted with 0-3 R6b; or aryl substituted with 0-3 R6b; R6a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, aryl or CF3; R6b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy; R11 is selected from H, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl substituted with 0-1 R11a; aryl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3, or phenyl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; W is â€”(CR8R8a)pâ€”; p is 0, 1, 2, 3, or 4; R8 and R8a, at each occurrence, are independently selected from H, F, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl and C3-C8 cycloalkyl; X is a bond; aryl substituted with 0-3 RXb; C3-C10 cycloalkyl substituted with 0-3 RXb; C3-C10 carbocycle substituted with 0-3 RXb; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 RXb; RXb, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; Y is a bond or â€”(CR9R9a)tâ€”Vâ€”(CR9R9a)uâ€”; t is 0, 1, 2, or 3; u is 0, 1, 2, or 3; R9 and R9a, at each occurrence, are independently selected from H, F, C1-C6 alkyl or C3-C8 cycloalkyl; V is a bond, â€”C(&boxH;O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”N(R19)â€”, â€”C(&boxH;O)NR19bâ€”, NR19bC(&boxH;O)â€”, â€”NR19bS(&boxH;O)2â€”, â€”S(&boxH;O)2NR19bâ€”, â€”NR19bS(&boxH;O)â€”, â€”S(&boxH;O)NR19bâ€”, â€”C(&boxH;O)Oâ€”, or â€”OC(&boxH;O)â€”; Z is H; C1-C8 alkyl substituted with 0-2 R12; C2-C6 alkenyl substituted with 0-2 R12; C2-C6 alkynyl substituted with 0-2 R12; aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12 is aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R13, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, or CF3; R14, at each occurrence, is independently selected from H, phenyl, benzyl, C1-C6 alkyl, or C2-C6 alkoxyalkyl; R15, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); R16, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); alternatively, â€”NR15R16 may be a heterocyclic ring selected from the group piperidinyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, homopiperidinyl, piperazinyl, and N-methylpiperizinyl; R17 is H, aryl, aryl-CH2â€”, C1-C6 alkyl, or C2-C6 alkoxyalkyl; R18, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); R19, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, â€”C(&boxH;O)â€”(C1-C6 alkyl) and â€”S(&boxH;O)2â€”(C1-C6 alkyl); R19b, at each occurrence, is independently selected from H, C1-C4 alkyl, phenyl, benzyl, and phenethyl; and R20 and R21, at each occurrence, are independently selected from H, C1-C4 alkyl, aryl, and aryl(C1-C2 alkyl)â€”.