Patent ID: 6471955
Filing Date: 2002-10-29
Classification: A61K,A61P,Y10S

Abstract:
A delivery system comprising: an active ingredient covalently bonded to a linker through an acid-sensitive covalent bond formed with a hydroxyl, CO2H, amino, mercapto, or enolizable carbonyl moiety of the active ingredient, said linker being covalently bonded to a portion of styrenic subunits of a crosslinked polystyrene polymer through a linker-polymer covalent bond selected from the group consisting of a nitrogen-carbon bond and a phosphorus-carbon bond, wherein the crosslinked polystyrene polymer is selected from the group consisting of poly[(4-dialkylaminomethyl)styrene], poly[(3-dialkylaminomethyl)styrene], and mixtures of poly[(4-dialkylaminomethyl)styrene] and poly[(3-dialkylaminomethyl)styrene].