Patent ID: 7566701
Filing Date: 2009-07-28
Classification: C12N

Abstract:
1. An aptamer that binds to a von Willebrand Factor target, wherein the aptamer modulates von Willebrand Factor-mediated platelet adhesion, activation and/or aggregation and the aptamer is PEG20K-NH2-mGmCmGmUdGdCdAmGmUmGmCmCmUmUmCmGmGmCdCmG-s-TmGdCdGdGTmGmCdCmUdCdCmGmUdCmAmCmGmC-3T (SEQ ID No. 291) (ARC1779), where “NH2” is a 5′-hexylamine linker phosphoramidite, “3T” is an inverted deoxythymidine, “T” is a dT, “s” is a phosphorothioate backbone modification, “mN” is a 2′-O Methyl containing residue, “PEG” is a polyethylene glycol and “dN” is a deoxy residue, and wherein the aptamer comprises a K D for von Willebrand Factor of less than 100 nM.