Patent ID: 8765766
Filing Date: 2014-07-01
Classification: A61K,A61P,C07D

Abstract:
1. A method for the treatment of osteoporosis, said method comprising administering to a subject in need thereof, an effective amount of a pyrimidine compound of general formula (I): stereoisomeric forms thereof in the pure state and mixtures of these stereoisomers, and if appropriate, the pure E isomers, the pure Z isomers and the E/Z mixtures, as well as physiologically acceptable addition salts thereof, solvates thereof and prodrugs thereof, wherein I) —R represents: wherein G represents an aromatic or non-aromatic, monocyclic or polycyclic heterocyclyl radical comprising 5 to 10 members, and wherein at least one of the rings contains 1 to 4 nitrogen atoms, said heterocyclyl radical being able to be itself optionally substituted by a (C wherein G represents an aromatic monocyclic heterocyclyl radical with 5 or 6 members containing 1 to 4 nitrogen atoms and substituted by an alkyl(C —R —R —R —R —R R II) —R represents a radical: wherein G is selected from the following radicals: wherein Het represents a monocylcic or polycyclic system, each ring being constituted by 4 to 10 aromatic or non-aromatic members, the ring or at least one of the rings containing 1 to 4 nitrogen atom, and being able to itself be substituted or non-substituted by one or more R —R —R —R III) —R is defined as previously in II); —R —R —R IV) —R is defined as previously in II); —R —R —R V) —R, —R —R VI) —R, —R —R VII) —R, —R —R —R VIII) —R, —R —R —R IX) —R and —R —R —R —R X) —R and —R —R —R —R XI) —R and —R —R —R —R XII) —R and —R —R —R —R with the proviso that the above radicals cannot simultaneously have the meaning: —R represents a radical (Ib) in which G is 1,2,3,4-tetrahydro-1,8-naphthyridin-7-yl, —R —R —R —R