Patent ID: 8569457
Filing Date: 2013-10-29
Classification: A61K,A61P,C12N

Abstract:
1. An engineered human Ribonuclease (RNase 1) polypeptide only differing in amino acid sequence from an RNase 1 protein comprising SEQ ID NO:2 by at least four amino acid substitutions, the at least four amino acid substitutions consisting of: (a) at least one amino acid substitution located within residues 85 to 94 of SEQ ID NO:2; (b) the amino acid substitution G38R of SEQ ID NO:2; and (c) at least two amino acid substitutions at amino acid residues selected from the group consisting of residues 4, 7, 11, 31, 32, 39, 41, 42, 66, 67, 71, 111 and 118 of SEQ ID NO:2.