Patent ID: 7897781
Filing Date: 2011-03-01
Classification: A61P,C07F

Abstract:
1. A compound of Formula (I): wherein: A is benzo or pyrido; wherein benzo is optionally substituted with a substituent selected from the group consisting of C and wherein pyrido is optionally substituted with a substituent selected from the group consisting of fluoro, chloro, bromo, and methyl; and pyrido is optionally further substituted with fluoro; D is d-2 X is O, S, S(═O), S(O W is C(R R wherein phenyl is optionally substituted with an aminocarbonyl, trifluoromethyl, or trifluoromethoxy substituent; or phenyl is optionally substituted with one to two substituents independently selected from the group consisting of C and wherein heteroaryl is optionally substituted with bromo or one to two substituents independently selected from the group consisting of methyl, fluoro, and chloro; R wherein p is an integer from 2 to 6; and wherein q is an integer from 0 to 4, such that the sum of p and q is less than or equal to six; wherein r is an integer from 1 to 4; and, wherein the phenyl portion of phenyl(C and further, wherein C R L is —(CH B is hydrogen, phenyl, naphthyl, or a heteroaryl selected from the group consisting of benzothiophenyl, benzo(1,3)dioxalyl, oxazolyl, thienyl, furanyl, and benzofuranyl; wherein the phenyl of B is optionally substituted with hydroxy, C and wherein the naphthyl of B is optionally substituted with 1 or 2 substituents selected from the group consisting of hydrogen, methyl, fluoro, chloro, bromo, C or, the phenyl or heteroaryl substituent of B is optionally substituted with a substituent independently selected from the group consisting of C and the phenyl or heteroaryl substituent of B is optionally further substituted with one to two fluoro or chloro substituents; provided that when B is hydrogen and L is absent or —(CH and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof; provided that a compound of Formula (I) is other than a compound wherein A is 5-fluoro-benzo, D is d-2, W is C(R a compound wherein A is 6-trifluoromethyl-benzo, D is d-2, W is C (R and further provided that when D is d-2, R