Patent ID: 6534509
Filing Date: 2003-03-18
Classification: A61P,C07D

Abstract:
A compound of formula (Ia): wherein:R1a is one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl; R2 is 4-fluoro; R3 is phenyl substituted at the 4-position with chloro and optionally substituted at the 2-position by aminocarbonyl, ureido or glycinamido; R4 is â€”N(R7)â€”; R5 is methylene; R6 is â€”C(O)â€”; and R7 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, alkylcarbonyl, alkylcarbonylalkyl, aralkylcarbonyl, aralkylcarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and alkoxycarbonyl; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.