Patent ID: 6169104
Filing Date: 2001-01-02
Classification: A61K,A61P,C07C,Y02A

Abstract:
A method of inhibiting the growth of a tumor cell, said method comprising contacting said tumor cell with a compound having the structure: ##STR34## or a pharmaceutically acceptable salt thereof; wherein: X, if present, is a member selected from the group consisting of ##STR35## A, together with the carbons to which it is bound, forms an optionally substituted 3, 4, 5 or 6 membered carbocylic or heterocyclic ring; R.sup.9 and R.sup.10 are members independently selected from the group consisting of hydrogen, alkyl and halogen; Y is a member selected from the group consisting of H, alkyl and alkoxy; Z is a member selected from the group consisting of ##STR36## Q is a member selected from the group consisting of H, alkyl and S-alkyl; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are members independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, halogen, nitro and amino; and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are members independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy and halogen; with the proviso that if Z is ##STR37## and Q is methyl, then Y is other than methoxy and ethoxy.