Patent ID: 6242476
Filing Date: 2001-06-05
Classification: A61P,C07D

Abstract:
A method of treating a patient having an inflammatory disease comprising administering an effective leukotriene A.sub.4 hydrolase inhibiting amount of a compound of the formula I or a pharmaceutically acceptable salt thereof, ##STR9##wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group, a lower alkanoyl group or a benzoyl group, and each phenyl ring of the phenyl-lower alkyl group and the benzoyl group can be substituted by a lower alkyl group, a lower alkoxy group or a halogen atom;R.sup.2 and R.sup.3 each represent a hydrogen atom or a lower alkyl group;R.sup.4 represents a hydroxyl group, a lower alkoxy group, a phenyl-lower alkoxy group, an amino group, a lower alkylamino group or a phenyl-lower alkylamino group;R.sup.5 represents a phenyl group or a naphthyl group, and the phenyl group and the naphthyl group can be substituted by a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, a lower alkylthio group or a halogen atom;""Z"" represents a sulfur atom or an oxygen atom;""A"" represents a lower alkylene group; and""n"" represents 0, 1 or 2.