Patent ID: 8105598
Filing Date: 2012-01-31
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated monoclonal antibody or an antigen binding fragment thereof, comprising a variable region of a heavy chain and a variable region of a light chain, and wherein either: (a) the variable region of the light chain comprises amino acids 37-47 of the amino acid sequence set forth as SEQ ID NO: 7, amino acid 60-68 of the amino acid sequence set forth as SEQ ID NO: 7, and amino acids 99-109 of the amino acid sequence set forth as SEQ ID NO: 7 and wherein the variable region of the heavy chain comprises amino acids 34-41 of the amino acid sequence set forth as SEQ ID NO: 10, amino acids 59-65 of the amino acid sequence set forth as SEQ ID NO: 10, and amino acids 105-109 of the amino acid sequence set forth as SEQ ID NO: 10; or (b) the variable region of the light chain comprises amino acids 37-42 of the amino acid sequence set forth as SEQ ID NO: 9, amino acids 60-69 of the amino acid sequence set forth as SEQ ID NO: 9, and amino acids 99-109 of the amino acid sequence set forth as SEQ ID NO: 9 and wherein the variable region of the heavy chain comprises SEQ ID NO: 12; and wherein the monoclonal antibody or the antigen binding fragment thereof specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (K