Patent ID: 6214822
Filing Date: 2001-04-10
Classification: A61P,C07D

Abstract:
A compound of the formula IAr.sup.1 --A--B--Ar.sup.2 (I)whereAr.sup.1 is a 6-membered heteroaromatic ring with 1 or 2 heteronitrogen atoms, where Ar.sup.1 may have 1, 2, 3 or 4 substituents which are selected, independently of one another, from OR.sup.1, alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.8 -alkyl or halogen, or C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, cycloalkyl, halogen, CN, CO.sub.2 R.sup.1, NO.sub.2, NR.sup.1 R.sup.2, SR.sup.1, CF.sub.3, CHF.sub.2, phenyl which is unsubstituted or substituted by C.sub.1 -C.sub.6 -alkyl, OC.sub.1 -C.sub.6 -alkyl, acyl, phenyl, amino, nitro, cyano or halogen, or phenoxy which is unsubstituted or substituted by C.sub.1 -C.sub.6 -alkyl, OC.sub.1 -C.sub.6 -alkyl or halogen, or C.sub.1 -C.sub.6 -alkanoyl or benzoyl;R.sup.1 is H, alkyl which is unsubstituted or substituted by OH, OC.sub.1 -C.sub.6 -alkyl, phenyl or halogen;R.sup.2 has the meanings stated for R.sup.1 or is COR.sup.1 or CO.sub.2 R.sup.1 ;A is a C.sub.4 -C.sub.15 -alkylene group or a C.sub.3 -C.sub.15 -alkylene group which comprises at least one group Z which is selected from O, S, NR.sup.1, a double and a triple bond, where R.sup.1 is as defined above,B is a 7- or 8-membered saturated ring with two nitrogen heteroatoms, the nitrogen heteroatoms being located in the 1,4 or 1,5 position and the ring being bonded in position 1 to the radical A and in position 4 or 5 to the radical Ar.sup.2, and it additionally being possible for the ring to have a double bond in position 3 or 4;Ar.sup.2 is phenyl, pyridyl, or pyrimidinyl, it being possible for Ar.sup.2 to have 1, 2, 3 or 4 substituents which are selected, independently of one another, from OR.sup.1, alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, alkoxyalkyl, haloalkyl, halogen, CN, CO.sub.2 R.sup.1, NO.sub.2, SO.sub.2 R.sup.1, NR.sup.1 R.sup.2, SO.sub.2 N R.sup.1 R.sup.2, SR.sup.1, a 5- or 6-membered carbocyclic, aromatic or non-aromatic ring and a 5- or 6-membered heterocyclic aromatic or non-aromatic ring with 1 to 3 heteroatoms which are selected from O, S and N. the carbocyclic or heterocyclic ring being unsubstituted or substituted by C.sub.1 -C.sub.8 -alkyl, phenyl, halogen, OC.sub.1 -C.sub.8 -alkyl, OH, NO.sub.2 or CF.sub.3, and Ar.sup.2 may also be fused to a carbocyclic ring of the type defined above, and where Ar.sup.2 cannot be a pyrimidinyl radical substituted by 2 hydroxyl groups, and the salts thereof with physiologically tolerated acids.