Patent ID: 6225446
Filing Date: 2001-05-01
Classification: A61K,C07K

Abstract:
An isolated or recombinant mutein of a mammalian Ob which comprises:a) an amino acid sequence that differs from SEQ ID NO: 1 by a non-conservative amino acid residue substitution, wherein said substitution is at a position selected from the following group:D29, D30, K32, T33, K36, T37, V39, T40, I42, N43, N99, D100, E102, N103, R105, D106, and L107;b) an amino acid sequence that differs from SEQ ID NO:2 by a non-conservative amino acid residue substitution, wherein said substitution is at a position selected from the following group:D29, D30, K32, T33, K36, T37, V39, T40, I42, N43, N99, D100, E102, N103, R105, D106, and L107; orc) an amino acid sequence that differs from SEQ ID NO:3 by a non-conservative amino acid residue substitution, wherein said substitution is at a position selected from the following group:D29, D30, K32, T33, K36, T37, V39, T40, I42, N43, N99, D100, E102, N103, R105, D106, and L107.