Patent ID: 6348602
Filing Date: 2002-02-19
Classification: A61P,C07D

Abstract:
A compound having the formula: wherein Y is OR5 or NR5R6;R1 is lower alkyl, bridged alkyl, aralkyl, cycloalkyl, a 5- or 6-membered saturated heterocycle, C1-3alkylenecycloalkyl, aryl- or heteroaryl-substituted propargyl, aryl- or heteroaryl-substituted allyl, or halocycloalkyl; R2 is hydrogen, methyl, or halo-substituted methyl; R3 is C(&boxH;O)OR7, C(&boxH;O)R7, C(&boxH;NH)NR8R9, C(&boxH;O)â€”NR8R9, aryl, or heteroaryl; R4 is hydrogen, lower alkyl, haloalkyl, cycloalkyl, or aryl; R5 and R6, independently, are hydrogen, lower alkyl, haloalkyl, cycloalkyl, aryl, heteroaryl, or alkaryl, or R5 and R6 are taken together form a 5-membered or 6-membered ring; R7 is branched or unbranched lower alkyl or aryl, and R7 can be optionally substituted with one or more of OR8, NR8R9, or SR8; and R8 and R9, same or different, are selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, and aralkyl, or R8 and R9 are taken together form a 4-membered to 7-membered ring; R10 is hydrogen, alkyl, haloalkyl, cycloalkyl, aryl, C(&boxH;O)alkyl, C(&boxH;O)cycloalkyl, C(&boxH;O)aryl, C(&boxH;O)Oalkyl, C(&boxH;O)Ocycloalkyl, C(&boxH;O)aryl, CH2OH, CH2Oalkyl, CHO, CN, NO2, or SO2R11; and R11 is alkyl, cycloalkyl, trifluoromethyl, aryl, aralkyl, or NR8R9.