Patent ID: 8148335
Filing Date: 2012-04-03
Classification: A61K,A61P,C07K,C08B,C08L,Y02A

Abstract:
1. A method of inhibiting growth of a cancerous cell in a subject, the method comprising: administering to a subject a pharmaceutically acceptable formulation comprising an isolated antibody that specifically binds a de-N-acetylated sialic acid (deNAc SA) epitope on an extracellularly accessible surface of a cancerous cell present in the subject, said deNAc SA epitope minimally defined by a dimer containing at least one de-N-acetylated sialic acid residue having a free amine adjacent an N-acylated sialic acid residue or a sialic acid derivative residue, said isolated antibody separated from cationic or other charged contaminants; wherein said administering facilitates reduction in viability of cancerous cells bound by the antibody.