Patent ID: 6703420
Filing Date: 2004-03-09
Classification: C07C,C07D

Abstract:
A compound of formula Ia or Ib: or stereoisomer or pharmaceutically acceptable salt form thereof, wherein;R1 is phenyl or naphthyl, and R1 is substituted with 0-2 Ra; Ra is selected from H, Cl, F, Br, I, C1-4 alkyl, C1-4 alkoxy, OH, CH2OH, NH2, (C1-3 alkyl)NH, (C1-3 alkyl)2N, (H2NCH2C(O))NH, (H2NCH(CH3)C(O))NH, (CH3NHCH2C(O))NH, ((CH3)2NCH2C(O))NH, CF3, OCF3, â€”CN, NO2, C(O)NH2, and CH3C(O)NH; Y is selected from phenyl substituted with 0-5 Rb, naphthyl substituted with 0-5 Rb, and CHR3, Rb is selected from H, Cl, F, Br, I, C1-4 alkyl, OH, C1-4 alkoxy, CH2OH, CH(OH)CH3, CF3, OCF3, â€”CN, NO2, NH2, (C1-3 alkyl)NH, (C1-3 alkyl)2N, and C(O)Oâ€”C1-4 alkoxy; R2 is selected from H, R2a, C(O)R2a, CH(OH)R2a, CH2R2a, OR2a, SR2a, and NHR2a; R2a is selected from phenyl, and naphthyl, and R2a is substituted with 0-5 Rb; R3 is phenyl substituted with 0-2 Rc or naphthyl substituted with 0-2 Rc; and, Rc is selected from H, Cl, F, Br, I, C1-4 alkyl, OH, C1-4 alkoxy, CH2OH, CH(OH)CH3, CF3, OCF3, â€”CN, NO2, NH2, (C1-3 alkyl)NH, (C1-3 alkyl)2N, and C(O)Oâ€”C1-4 alkoxy.