Patent ID: 6191142
Filing Date: 2001-02-20
Classification: A61P,C07D

Abstract:
A method for the treatment of neuropathic pain comprising the step of administering to a mammal suffering from such condition an effective amount, in a pharmaceutically acceptable carrier, of an active compound of the formula: ##STR57##wherein,A is ##STR58##n is an integer from 1 to 5;R.sup.1 is selected from the group consisting of H and C.sub.1-4 alkyl;R.sup.2 and R.sup.3 are selected from the group consisting of H and C.sub.1-4 alkyl;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, C.sub.1-4 alkyl, phenyl C.sub.1-4 alkyl and substituted phenyl C.sub.1-4 alkyl where the substituent is on phenyl and selected from the group consisting of methyl and methoxy, or in the alternative, are fused and together with said nitrogen form a heterocyclic ring selected from the group consisting of 4-[bis(4-fluorophenyl)methylene]-piperidin-1-yl, 1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinolin-2-yl, ##STR59##wherein Y is S or O, x is 3 to 7 and R.sup.7 is selected from the group consisting of methyl and hydroxymethyl; andR.sup.6 is selected from the group consisting of halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, nitro, amino, C.sub.1-4 acylamino, cyano, trihaloC.sub.1-4 alkyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfinyl, and C.sub.1-4 acyl,including pharmaceutically acceptable acid addition salts thereof.