Patent ID: 8679760
Filing Date: 2014-03-25
Classification: C07H,C07K,C12Q,G01N

Abstract:
1. A method for evaluating risk of proliferation, invasion, or metastasis of a cancer, comprising the following steps: (A) providing a tissue sample to evaluate for risk of proliferation, invasion, or metastasis of a cancer, wherein the tissue sample comprises a non-cancer region, and a suspected cancer region, and the tissue sample is one selected from the group consisting of liver tissue, breast tissue, pancreas tissue, brain tissue, thymus tissue, prostate tissue, and colon tissue; (B) detecting expression levels of a biomarker and a predetermined standard in the non-cancer region and the suspected cancer region respectively, wherein the biomarker is T-cell lymphoma invasion and metastasis 2 (TIAM2); (C) comparing the expression levels of the biomarker and the predetermined standard in the non-cancer region to the expression levels of the biomarker and the predetermined standard in the suspected cancer region through the following equation (I): wherein when the value is positive, this indicates high risk of proliferation, invasion, or metastasis of liver cancer, breast cancer, thymus cancer, prostate cancer, colon cancer, pancreas cancer, or other solid cancers; and when the value is negative, this indicates high risk of proliferation, invasion, or metastasis of brain cancer.