Patent ID: 9138492
Filing Date: 2015-09-22
Classification: A61K

Abstract:
1. A particle encapsulating a hydrophobic dye having a cyanine structure, the particle further comprising surfactants, wherein the surfactants are a polyoxyethylene sorbitan-based fatty acid ester and a phospholipid, wherein a size of the particle is from 1 nm to 200 nm, and wherein the hydrophobic dye is selected from the group consisting of 1,1′,3,3,3′,3′-hexamethylindotricarbocyanine iodide (chemical formula (A1)); 3H-indolium, 1-ethyl-2-[7-(1-ethyl-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene)-1,3,5-heptatrien-1-yl]-3,3-dimethyl-, iodide (chemical formula (A2)); 2-[2-[2-chloro-3-[2-(1,3-dihydro-1,1,3-trimethyl-2H-benzo[e]-indol-2-ylidene)-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-1,1,3-trimethyl-1H-benzo[e]indoliumperchlorate (chemical formula (A3)); 1,1′,3,3,3′,3′-hexamethylindotricarbocyanine perchlorate (chemical formula (C1)); and 1,1′,3,3,3′,3′-hexamethyl-4,4′,5,5′-dibenzo-2,2′-indotricarbocyanine perchlorate (chemical formula (C2)):