Patent ID: 6764509
Filing Date: 2004-07-20
Classification: A61F,A61L

Abstract:
A biocompatible heart valve comprising:a stent defining a blood flow path; and a plurality of polymeric leaflets having a surface coating to provide resistance to in vivo pathologic thrombus formation and in vivo pathologic mineralization, wherein the surface coating comprises a precursor of the formula: Xâ€”Yâ€”Z wherein X is a chemically reactive group capable, upon activation, of bonding to the surface of the heart valve; Y comprises a compound selected from the group consisting of a C1-C10 alkyldiol; a C1-C10 diamine; a polyethyleneoxide (PEO); an amino-substituted PEO (MW=200-1450); a diamine-terminated PEO (MW=200-1450); &egr;-amino caproic acid (EAC); ethylene diamine (ED); diaminopropane (DAP), and derivatives of the foregoing; and Z is a fatty acid moiety, a hyaluronic acid moiety, a polyoxyethylene moiety, or a vinylpyrrolidone moiety.