Patent ID: 9095618
Filing Date: 2015-08-04
Classification: A61K,A61P,C07F,C07K

Abstract:
1. A conjugate comprising a polymeric backbone derived from polyglutamic acid (PGA) and comprising a plurality of backbone units covalently linked to one another, wherein a portion of said plurality of backbone units has an anti-angiogenesis agent attached thereto, and another portion of said plurality of backbone units has a bisphosphonate bone targeting moiety attached thereto, the conjugate being represented by the general formula I: wherein: x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 70 to 99.8; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15; and w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15, A B is said anti-angiogenesis agent; D is said bone targeting moiety; and each of the L such that [A [A wherein each of the [A