Patent ID: 8791113
Filing Date: 2014-07-29
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) wherein: W W Z denotes C═C, NR R R R R R Y denotes H or A, and in case of its occurrence in —(CYY) A denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 H atoms are optionally replaced independently from one another by Hal and/or in which one or two CH Het denotes a saturated or unsaturated, mono, bi- or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, which are optionally substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, o denotes 0, 1, 2, 3 or 4, p denotes 0, 1, 2 or 3, and q denotes 0, 1, 2 or 3, with the proviso that the following compounds are excluded: (a) 2-(5-chloro-2-fluoro-phenyl)-4-isoquinolin-4-yl-[1,8]naphthyridine, (b) 4-isoquinolin-4-yl-2-(6-methyl-pyridin-2-yl)-[1,8]naphthyridine, (c) 4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,7]naphthyridin-1-ylamine, (d) 4-[2-(2,5-difluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,7]naphthyridin-1-ylamine, (e) N-{4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,7]naphthyridin-1-yl }-acetamide, (f) 2-(2-fluoro-phenyl)-4-[2,7]naphthyridin-4-yl-[1,8]naphthyridine, (g) 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,7]naphthyridin-1-ylamine, (h) 5-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[1,7]naphthyridine, and (i) 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,7]naphthyridin-1-ylamine, or a pharmaceutically acceptable salt, solvate, stereoisomer or tautomer thereof.