Patent ID: 7015235
Filing Date: 2006-03-21
Classification: A61K,A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein r is 1 or 2; s is 1; n is 0, 1 or 2; p is 0, 1, or 2; R in which phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 ; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; R in which phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 ; R in which heteroaryl is as defined above; phenyl, naphthyl, heteroaryl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy; and (CH 2 ) n is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; each R wherein cycloalkyl is unsubstituted or substituted with one to three groups independently selected from halogen, C 1-4 alkyl, and C 1-4 alkoxy; or two R 4 groups together with the atom to which they are attached form a 4- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and NC 1-4 alkyl; each R wherein heteroaryl is as defined above; phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 3 ; and alkyl, cycloalkyl, and (CH 2 ) n are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; or two R 5 groups together with the atom to which they are attached form a 5- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and NC 1-4 alkyl; X is wherein alkyl, and (CH 2 ) n , are unsubstituted or substituted with one to three groups independently selected from R 3 and oxo; and Y is cyclohexyl, wherein cyclohexyl is optionally substituted with one to three groups independently selected from R 3 and oxo.