Patent ID: 8541569
Filing Date: 2013-09-24
Classification: C07H

Abstract:
1. A compound of Formula Ia or Ib: or a salt thereof, wherein: J is H, wherein indicates where J is attached to the O atom; Q is a support comprised of: a) a linking group and a spacer that can be cleaved to form a hydroxy group; or b) an aliphatic chain, aromatic group, substituted or unsubstituted aromatic, a substituted or unsubstituted phenoxy, or levulinyl; R R or R R R wherein R 4 is further selected from O—Si(R 11 ) 3 or O—CH 2 —Si(R 11 ) 3 ; or when Structural Formula Ia or Ib is: R 4 is further selected from —OC(═O)R 12 ; each R R each R each R each R each R each R each R Z is an unsubstituted or substituted aryl group, an unsubstituted or substituted triarylmethyl group, an unsubstituted or substituted trityl group, an unsubstituted or substituted tetrahydropyranyl group, or an unsubstituted or substituted 9-phenylxanthyl; B N6,N6-dimethyl adenine, N-1 methyladenine, 7-deazaadenine, 7-deaza-8-azaadenine, 3-deazaadenine, ethenoadenine, isoguanine, N1-methylguanine, 7-iodo-7-deazaguanine, 7-deaza-7-iodoadenine, 7-deaza-7-iodo-6-oxopurine, 5-iodo-5-methyl-7-deazaguanine, 7-deazaguanine substituted with —C≡C(CH wherein any substitutable nitrogen atom within the nucleobase or on the exocyclic amine is optionally substituted with fluorenylmethyloxycarbonyl; —C(═O)OPh; —C(═O)(C wherein any substitutable oxygen atom within the nucleobase is optionally substituted with —C(═O)N(C