Patent ID: 7452967
Filing Date: 2008-11-18
Classification: A61K,C07K,C12N,C12Q,G01N

Abstract:
1. An isolated polypeptide selected from the group consisting of: a) a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO: 11, wherein the fragment comprises the CARD domain of residues 6-112 of SEQ ID NO: 11, wherein the fragment binds Bcl-10; b) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 11, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule consisting of the entire complement of SEQ ID NO: 12 under conditions of incubation at 45° C. in 6.0X SSC followed by washing in 0.2X SSC/0.1% SDS at 65° C., wherein the variant binds Bcl-10 and comprises a CARD domain; c) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to SEQ ID NO: 10, 12, wherein the polypeptide binds Bcl-10 and comprises a CARD domain; and d) a polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 11, wherein the polypeptide binds Bcl-10 and comprises a CARD domain.