Patent ID: 9192615
Filing Date: 2015-11-24
Classification: A61K

Abstract:
1. An oral dosage form, comprising: 65 mg of minocycline; a first amount of lactose monohydrate present as an extragranular fast dissolving carrier and a second amount of lactose monohydrate present as an intragranular fast dissolving carrier; an amount of hydroxypropylmethylcellulose present as an intragranular slow dissolving carrier, wherein the hydroxypropylmethylcellulose is selected from the group consisting of hydroxypropylmethylcellulose that is 8.9%+/−0.2% hydroxypropoxylated and hydroxypropylmethylcellulose that is about 9.1% hydroxypropoxylated, wherein the hydroxypropylmethylcellulose has a viscosity of 40 cps to 60 cps; wherein the ratio of the extragranular fast dissolving carrier to intragranular slow dissolving carrier is from 0.30 to 0.50; wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 37% within 1 hour, about 61% within 2 hours, and 90% within 3 hours when the hydroxypropylmethylcellulose is 8.9+/−0.2% hydroxypropoxylated, and wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 41% within 1 hour, about 68% within 2 hours, about 90% within 3 hours and about 100% within 4 hours when the hydroxypropylmethylcellulose is about 9.1% hydroxypropoxylated.