Patent ID: 8178348
Filing Date: 2012-05-15
Classification: A61P,C12N

Abstract:
1. An oligonucleotide ‘chimera’ to selectively prevent gene expression in a sequence-specific manner, consisting of a chimera of modified arabinose and 2′-deoxy sugars consisting of the formula: wherein, x≧1, y≧1, and z≧0; Y at the internucleotide phosphate linkage is sulfur; X at the furanose ring (position 4′) is selected from the groups oxygen, sulfur, and methylene (CH Z at the 2′ position of the sugar ring is selected from the group consisting of a halogen, alkyl, alkylhalide, allyl, amino, aryl, alkoxy, and azido; and, wherein the modified arabinose sugars are in D-configuration.