Patent ID: 9078866
Filing Date: 2015-07-14
Classification: A61K,A61P

Abstract:
1. A method for treating hyperglycemia, comprising the step of administering to a human subject having a fasting blood glucose concentration greater than about 7 mmol/L an inhalable dry powder formulation comprising microparticles comprising a therapeutically effective amount of a glucagon like peptide-1 (GLP-1) molecule and a diketopiperazine, wherein the GLP-1 molecule is a native GLP-1, a GLP-1 metabolite, a GLP-1 analog, a long acting GLP-1 analog, a GLP-1 mimetic, a GLP-1 peptide analog, a biosynthetic GLP-1 analog, or a combination thereof, wherein said GLP-1 has at least one biological activity of native GLP-1, and wherein said GLP-1 comprises GLP-1 in an amount from about 0.5 mg to about 3 mg of GLP-1 in the formulation and the formulation does not comprise a dipeptidyl-peptidase-IV (DPP-IV) inhibitor, and wherein the diketopiperazine is 2,5-diketo-3,6-di(4-X-aminobutyl)piperazine, wherein X is selected from the group consisting of succinyl, glutaryl, maleyl, and fumaryl; or a pharmaceutically acceptable salt thereof, and further wherein peak blood GLP-1 concentration is reached within about 20 minutes after administration.