Patent ID: 6180629
Filing Date: 2001-01-30
Classification: C07D

Abstract:
A compound of the formula: ##STR4##wherein Y.sub.1 is selected from the group consisting of --(CH.sub.2).sub.n --C(O)--NH--, --NH--, --NH--C(X)--O--, and --NH--C(O)--NH--; where X is oxygen or sulfur, and n is an integer from 1 to 3;R.sub.1 and R.sub.2 are independently selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolidinyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, morpholinyl, tetrazolyl, triazinyl, furfuryl and thiophenyl, wherein said substituents are one to three independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, nitro, nitrile, --CO.sub.2 H, --SO.sub.2 NH.sub.2, lower alkyl mercapto, and lower alkyl sulfonyl;Y.sub.2 is selected from the group consisting of lower alkylene, lower (hydroxy) alkylene, lower (amino) alkylene, lower (alkylamino) alkylene, carbonyl, and --CH.sub.2 --NH--;A is a ring fused with the pyridazine ring selected from the group consisting of benzene and pyridinyl;R.sub.3 is independently selected in each instance from the group consisting of halogen, lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxy, nitro, nitrile, --CO.sub.2 H, --SO.sub.2 NH.sub.2, lower alkyl mercapto, and lower alkyl sulfonyl;m is an integer from 0 to four;p is 0 or 1;or pharmaceutically acceptable salts thereof.