Patent ID: 6277840
Filing Date: 2001-08-21
Classification: A61P,C07C,C07D

Abstract:
Compound of the formula ##STR69##or the pharmaceutically acceptable salts thereof, whereinX denotes CH--R.sup.4,R.sup.4 denotes ##STR70##wherein R.sup.5 to R.sub.7 independently of one another denote H, alkyl, cycloalkyl, alkenyl, aryl, aralkyl, alkanoyl, benzoyl, heteroaryl, dialkylamino, dialkylaminoalkyl, trialkylammoniumalkyl, cyano, alkyloxycarbonyl, aralkyloxycarbonyl, OH, O-alkyl or O-aryl, wherein the alkyl groups contain 1 to 5 carbon atoms, the cycloalkyl groups contain 3 to 6 carbon atoms, the alkenyl groups contain 2 to 5 carbon atoms.aryl denotes phenyl, or phenyl or naphthyl substituted by methyl, F, Cl, Br or I;or R.sup.5 and R.sup.6 or R.sup.6 and R.sup.7 together form the group (CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.2 O(CH.sub.2).sub.2 ;R.sup.8 =H, alkyl with 1 to 5 carbon atoms or cycloalkyl with 3 to 6 carbon atoms orR.sup.7 +R.sup.8 together form the group --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.2 O(CH.sub.2).sub.2 --;or R.sup.4 denotes ##STR71##wherein R.sup.5 is as hereinbefore defined;Y denotes CH.sub.2 ;Z denotes O or H.sub.2 ;Ar denotes unsubstituted or mono- to 5-substituted phenyl, or unsubstituted or mono- or disubsti-tuted naphthyl wherein the substituents of the phenyl and naphthyl independently of one another denote F, Cl, Br, I, OH, (C.sub.1 -.sub.4)alkyl, O--(C.sub.1 -.sub.4)alkyl, CF.sub.3, OCF.sub.3 or NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 independently of one another denote H, methyl or acetyl or Ar is phenyl substituted by --OCH.sub.2 O-- or --O(CH.sub.2).sub.2 O--;R.sup.1 denotes phenyl(C.sub.1 -.sub.4)alkyl or phenyl(C.sub.1 -.sub.4)alkanoyl or naphthyl(C.sub.1 -.sub.4)alkyl or naphthylacetyl, wherein phenyl may be substituted by 1 to 3 substituents, wherein the substituents independently of one another denote F, Cl, Br, I, (C.sub.1 -.sub.4)alkyl, O--(C.sub.1 -.sub.4)alkyl, CF.sub.3, OCF.sub.3 or NR.sup.19 R.sup.20 wherein R.sup.19 and R.sup.20 independently of one another denote H, methyl or acetyl; andR.sup.2 denotes H, (C.sub.1 -.sub.4)alkyl, (C.sub.3 -.sub.6)cycloalkyl, CH.sub.2 COOH, --CH.sub.2 C(O)NH.sub.2, OH or phenyl(C.sub.1 -.sub.4)alkyl.