Patent ID: 6159979
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a salt thereof: ##STR7## in which R.sup.a is a group of formula (i) ##STR8## is selected from the group consisting of naphthyl, indanyl, tetrahydronaphthyl, 2,3-dihydrobenzofuryl, quinoline, isoquinoline, indole, benzofuran, benzothiazole and benzothiadiazole.R.sup. is hydrogen, halogen, C .sub.1-6 alkyl, C.sub.3-6 cycloalkyl, COC.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkoxy, C .sub.1-6 alkanoyl, nitro, trifluoromethyl, cyano, SR.sup.9, SOR.sup.9, SO.sub.2 R.sup.9, SO.sub.2 NR.sup.10 R.sup.11,CO.sub.2 R.sup.10, CONR.sup.10 R.sup.11,CO.sub.2 NR.sup.10 R.sup.11,CONR.sup.10 (CH.sub.2).sub.c CO.sub.2 R.sup.11, (CH.sub.2).sub.c NR.sup.10 R.sup.11, (CH.sub.2).sub.c CONR.sup.10 R.sup.11,(CH.sub.2).sub.c NR.sup.10 COR.sup.11,(CH.sub.2).sub.c CO.sub.2 C.sub.1-6 alkyl, CO.sub.2 (CH.sub.2).sub.c OR.sup.10, NR.sup.10 R.sup.11, NR.sup.10 CO.sub.2 R.sup.11, NR.sup.10 CONR .sup.10 R.sup.11, CR.sup.10 .dbd.NOR.sup.11, CNR.sup.10 .dbd.NOR .sup.11, where R.sup.9, R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 alkyl and c is 1 to 4;R.sup.2 is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkanoyl, phenyl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO.sub.2 R.sup.10, CONR.sup.10 R.sup.11, NR.sup.10 R.sup.11 I where R.sup.10 and R.sup.11 are as defined for R.sup.1 ; ais 1,2or3;or R.sup.a is a group of formula (ii) ##STR9## thienyl, furyl, pyrrolyl, triazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, isothiazolyl, isoxazolyl, thiadiazolyl, pyrimidyl, pyrazinyl, or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur, providing that at least one of P.sup.2 and P.sup.3 is a bicyclic aryl or bicyclic heterocyclic group;A is a bond or oxygen, S(O).sub.m where m is 0 to 2, carbonyl, CH.sub.2 or NR.sup.4 where R.sup.4 is hydrogen or C.sub.1-6 alkyl;R.sup.1 is as defined above for formula (i) or is a 5 to 7-membered heterocyclic ring, containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur, optionally substituted by C.sub.1-6 alkyl, halogen or C.sub.1-6 alkanoyl;R.sup.2 and R.sup.3 are independently hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 cycloalkenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkanoyl, phenyl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO.sub.2 R.sup.10, CONR.sup.10 R.sup.11, NR.sup.10 R.sup.11 where R.sup.10 and R.sup.11 are as defined for R.sup.1 ; and a and b are independently 1, 2 or 3;L is a group of formula--C(.dbd.V)--DG--or--DG--C(.dbd.V)--or--Y--C(.dbd.V)--DG.sup.1 --V is oxygen or sulphur;D is nitrogen, carbon or a CH group, G and G.sup.1 are each hydrogen or C.sub.1-6 alkyl, providing that D is nitrogen or a CH group, or G together with R.sup.b1 forms a group W where W is (CR.sup.16 R.sup.17).sub.t where t is 2, 3 or 4 and R.sup.16 and R.sup.17 are independently hvdrogen or C.sub.1-6 alkyl or W is (CR.sup.16 R.sup.17).sub.u -J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR.sup.16 .dbd.CR.sup.17, CR.sup.16 .dbd.N, .dbd.CR.sup.16 O, .dbd.CR.sup.16 S or .dbd.CR.sup.16 --NR.sup.17 ;Y is --NH--or --NR.sup.5 -- where R5 is C .sub.1-6 alkyl,or Y is --CH2-- or --O--:X is nitrogen or carbon;R.sup.b1 and R.sup.b2 are independently hydrogen, halogen, hydroxy, C.sub.1-6 alkyl, trifluoromethyl, C.sub.1-6 alkoxy or phenyl, or R.sup.b1 together with G forms a group W as defined above;R.sup.c is hydrogen or C.sub.1-6 alkyl; and --is a single bond when X is nitrogen, or a single or double bond when X is carbon.