Patent ID: 6706736
Filing Date: 2004-03-16
Classification: C07D

Abstract:
A method of treating a subject suffering from a condition requiring SSR inhibition selected from the group consisting of post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obesity, eating disorders, vasomotor flushing, cocaine and alcohol addiction, and sexual dysfunction which comprises providing to the subject suffering from said condition, a SSR inhibitory effective amount of a compound of formula I whereinR1, R3, R4, R5 and R7 are, independently, hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; Y is C&boxH;O or C(R2)2 and Z is CH2, CH2CH2, CH&boxH;CH or NR2, or Y and Z, taken together, form CR2&boxH;CH, N&boxH;CR2 or CR2&boxH;N; R2 and R6 are hydrogen or alkyl of 1 to 6 carbon atoms; X is CR7 or N; A dotted line represents an optional double bond; and n is an integer 0, 1 or 2; or a pharmaceutically acceptable salt thereof.