Patent ID: 8318690
Filing Date: 2012-11-27
Classification: A61K,A61P,C12N

Abstract:
1. A method of modulating a function of and/or the expression of a Hemoglobin (HBF/HBG) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded oligonucleotide 5 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 50% sequence identity to a reverse complement of a Hemoglobin (HBF/HBG) polynucleotide comprising 5 to 30 consecutive nucleotides within nucleotides 1 to 570 of SEQ ID NO: 3; thereby modulating a function of and/or the expression of the Hemoglobin (HBF/HBG) polynucleotide in patient cells or tissues in vivo or in vitro.