Patent ID: 6869973
Filing Date: 2005-03-22
Classification: A61K,A61P,B82Y,C07D,Y10S

Abstract:
1. A composition comprising at least one compound selected from the group consisting of 15-((3S,2R)-2-hydroxy-3-phenyl-3-(phenylcarbonylamino)propanoyloxy) (2S,4S,9S,10S,15S,7R,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-6-oxa-11-oxo-2-phenylcarbonyloxytetracyclo(11.3.1.0<3,10>0.0<4,7>)heptadec-13-en-9-yl 3-methyl-3-(nitrosothio)butanoate; (1S,2S,4S,9S,10S,15S,7R,12R)-4,12-diacetyloxy-1,9-dihydroxy-10,14,17,17-tetramethyl-6-oxa-11-oxo-2-phenylcarbonyloxytetracyclo(11.3.1.0<3,10>0.0<4,7>) heptadec-13-en-15-yl(3S,2R)-2-(2-({N-(2-methyl-2-(nitrosothio)propyl) carbamoyl}methoxy)acetyloxy)-3-phenyl-3-(phenylcarbonylamino)propanoate; 9-(2-({((2R)-2,3-bis(nitrooxy)propyl)oxycarbonyl}methoxy)acetyloxy)(1S,2S,4S,9S,10S,15S,7R,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-6-oxa-11-oxo-2-phenylcarbonyloxytetracyclo(11.3.1.0<3,10>0.0<4,7>)heptadec-13-en-15-yl 2-(2-({((2R)-2,3-bis(nitrooxy)propyl)oxycarbonyl}methoxy)acetyloxy)(3S,2R)-3-phenyl-3-(phenylcarbonylamino)propanoate; (1S,2S,4S,9S,10S,15S,7R,12R)-4,12-diacetyloxy-9-{2-(({2,2-bis((nitrooxy)methyl)-3-(nitrooxy)propyl}oxycarbonyl)methoxy)acetyloxy}-1-hydroxy-10,14,17,17-tetramethyl-6-oxa-11-oxo-2-phenylcarbonyloxytetracyclo (11.3.1.0<3,10>0.0<4,7>)heptadec-13-en-15-yl(3S,2R)-2-{2-(({2,2-bis((nitrooxy)methyl)-3-(nitrooxy)propyl}oxycarbonyl)methoxy)acetyloxy}-3-phenyl-3-(phenylcarbonylamino)propanoate, or a pharmaceutically acceptable salt thereof, and at least one compound that donates, transfers, or releases nitric oxide, or induces the production of endogenous nitric oxide or endothelium-derived relaxing factor or is a substrate for nitric oxide synthase or a pharmaceutically acceptable salt thereof.