Patent ID: 7772236
Filing Date: 2010-08-10
Classification: A61P,C07D

Abstract:
1. A method for inhibiting the proteolytic activity of human cathepsin S comprising contacting human cathepsin S with a compound of formula (I) below: wherein: R R each of R R R R R R alternatively, R R R R alternatively, R each of R R R alternatively, R each of R alternatively, R each of R alternatively, R n is 1; G represents C each of R L is amino, mono- or di-C X is nitrogen or R Y is nitrogen or R Z is nitrogen or R with the following provisos: 1) when Z and Y are each N, then X is N, and 2) when X is R R R R Ar represents a monocyclic or bicyclic aryl or heteroaryl ring, optionally substituted with between 1 and 3 substituents selected from halogen, C R R alternatively, R each of R each of R alternatively, R W represents SO wherein X R R R alternatively, R R R R alternatively, R wherein each of the above hydrocarbyl or heterocarbyl groups, unless otherwise indicated, and in addition to any specified substituents, is optionally and independently substituted with between 1 and 3 substituents selected from methyl, halomethyl, hydroxymethyl, halo, hydroxy, amino, nitro, cyano, C or a pharmaceutically acceptable salt, ester, or amide thereof.