Patent ID: 6423842
Filing Date: 2002-07-23
Classification: A61P,C07D

Abstract:
An azacyclic ring system having the formula Iincluding geometrical isomers, enantiomers, diastereomers, racemates, acid addition salts, and salts thereof with a pharmaceutically acceptable acid, whereinQ is X is â€”CH2â€”, â€”NHâ€”, â€”Oâ€” or â€”Sâ€”; V, W, Y and Z independently are CH or N; n is 0 and m is 2, or n is 2 and m is 0; R1 and R2 are at any position on the azacyclic ring, including the point of attachment of the heterocycle Q, and independently are hydrogen, â€”OH, halogen, â€”NH2, carboxy, straight or branched C1-10-alkyl, C1-10-alkenyl, or C1-10-alkynyl, straight or branched C1-10-alkoxy, or straight or branched C1-10-alkyl substituted with â€”OH, â€”CN, â€”CHO, â€”OH, â€”OR3, â€”SR3, â€”NH2, â€”NHR3, â€”NR3R4, â€”NO2, â€”SOR3, â€”SO2R3, â€”COR3, â€”CO2R3, â€”CONH2, â€”CONHR3, â€”CONR3R4, or â€”CH&boxH;NOR3; or R1 and R2 independently are phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl, each of which are unsubstituted or substituted with halogen, â€”CN, C1-10-alkyl, C1-10-alkoxy, or C1-10-alkylthio; R is hydrogen, halogen, â€”CN, â€”CHO, â€”OH, â€”OR3, â€”SR3, â€”NH2, â€”NHR3, â€”NR3R4, â€”NO2, â€”SOR3, â€”SO2R3, â€”COR3, â€”CO2R3, â€”CONH2, â€”CONHR3, â€”CONR3R4, or â€”CH&boxH;NOR3; or R is phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl, each of which are unsubstituted or substituted with halogen, â€”CN, C1-15-alkyl, C1-10-alkoxy, or C1-10-alkylthio; or R is a 5 or 6 membered saturated, partly saturated or aromatic heterocyclic ring, wherein one to three of the ring members is a heteroatom; and R3 and R4 independently are straight, branched, or cyclic C1-15-alkyl, C2-15-alkenyl, C2-15-alkynyl, or combinations thereof, or R3 and R4 independently are phenyl, phenoxy, benzoyl, benzyl or benzyloxycarbonyl groups, each of which are unsubstituted or substituted with H, halogen, â€”CN, C1-15-alkyl, C1-10-alkoxy, C1-10-alkylthio, or aryl; or R3 and R4 independently are 5 or 6 membered saturated, partly saturated or aromatic heterocyclic rings having one to three heteroatoms.