Patent ID: 6251900
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A heterocyclic compound in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which is represented by the formula I or a pharmaceutically acceptable acid addition salt thereof: ##STR7##wherein X and Y represent a nitrogen atom, or one of X or Y represents a nitrogen atom and the other represents CR.sub.7, wherein R.sub.7 represents hydrogen or a halogen atom;R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 each represent a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sub.3 representsmorpholino optionally substituted with one or two C.sub.1 -C.sub.6 alkyl groups, trifluoromethyl, hydroxymethyl, monohalogenomethyl or CH.sub.2 NR.sub.8 R.sub.9, wherein R.sub.8 represents a hydrogen atom or C.sub.1 -C.sub.6 alkyl, and R.sub.9 represents a hydrogen atom, C.sub.1 -C.sub.6 alkoxycarbonyl or benzyl; piperidino optionally substituted with hydroxy, acetoxy, oxo, 4,4-ethlenedioxy or amino C.sub.1 -C.sub.6 alkyl; piperazinyl optionally substituted with C.sub.1 -C.sub.6 alkyl; thiomorpholino; benzimidazolyl; cyano; orNR.sub.10 R.sub.11 wherein R.sub.10 and R.sub.11 represent a hydrogen atom, C.sub.1 -C.sub.6 alkyl, hydroxy C.sub.1 -C.sub.6 alkyl or morpholino C.sub.1 -C.sub.6 alkyl.