Patent ID: 8932590
Filing Date: 2015-01-13
Classification: A61M,B01J

Abstract:
1. A method of treating cancer of a tumor-bearing mammal by adsorbing transforming growth factor β having a molecular weight of about 25,000 which is combined with another protein, said method comprising providing an extracorporeal perfusion column containing an adsorbent comprising a water-insoluble carrier having a surface to which quaternary ammonium groups are attached, each quaternary ammonium group having 8 to 18 carbon atoms per one nitrogen atom and at least one carbon chain having not less than 6 carbon atoms, said adsorbent having a specific surface area of 0.1 m 2 or more per one gram, said extracorporeal perfusion column containing said adsorbent in an amount such that the adsorptivity of the transforming growth factor β of the extracorporeal perfusion column is 250 ng or more per 1 kg of the body weight of said tumor-bearing mammal; and conducting extracorporeal perfusion of a body fluid of the tumor-bearing mammal through said extracorporeal perfusion column.