Patent ID: 7268164
Filing Date: 2007-09-11
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of inhibiting epileptogenesis, comprising administering to a subject in need thereof an effective amount of a substituted β-amino anionic compound, comprising an amino group, an anionic group, and a two-carbon spacer unit, wherein said anionic group is a carboxylate; and said amino group is —NR wherein said two-carbon spacer unit may be substituted with a substituent selected from the group consisting of halogen, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino, acylamino, amidino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, azido, heterocyclyl, aromatic, and heteroaromatic moieties; or a pharmaceutically acceptable salt or ester thereof, such that epileptogenesis is inhibited.