Patent ID: 7754441
Filing Date: 2010-07-13
Classification: A61K,C07K

Abstract:
1. The method of patient selection for treatment of B cell lymphoma, said method comprising detecting in tumor samples from prospective patients'cells that have: (a) no or negative expression of a first polypeptide having an amino acid sequence shown in (b) no or negative expression of a first polypeptide having an amino acid sequence shown in (c) no or negative expression of a first polypeptide having an amino acid sequence shown in (d) no or negative expression of a first extracellular domain of the polypeptide shown in (e) no or negative expression of a first polypeptide encoded by the nucleotide sequence shown in (f) no or negative expression of a first polypeptide encoded by the full-length coding region of the nucleotide sequence shown in selecting said patient based on detection of at least one of (a) through (f), wherein the selection of said cells from said tumor samples indicates the identification of a patient for treatment with an antibody conjugated to a growth-inhibitory agent or a cytotoxic agent, wherein said conjugated antibody binds to said second polypeptide or second extracellular domain and is significantly internalized in comparison to cells that express the first polypeptide or first extracellular domain, thereby providing effective treatment.