Patent ID: 6864285
Filing Date: 2005-03-08
Classification: A61P,C07C,C07D

Abstract:
1. Compounds of the general formula (I): their enantiomers, diastereomers, racemates and mixtures thereof, in which: (a) R (1) a linear or branched alkyl radical, saturated or with from 1 to 6 double bonds, a monocyclic or polycyclic alkyl or alkenyl radical, or an aryl, arylalkyl or heterocyclic radical having one or more heteroatoms, the radicals optionally being substituted with one or more groups selected from hydroxy, acylamide, keto, nitro, alkoxy, halogen, —N (2) a group of formula (II): in which R 4 is a linear or branched alkylene radical saturated or with from 1 to 6 double bonds, a cycloalkylene or cycloalkenylene radical, or an aryl, arylalkyl or heterocyclic diradical with one or more heteroatoms, the radicals optionally being substituted with one or more groups selected from hydroxy, acylamide, keto, nitro, alkoxy, halogen, R 5 and R 6 have the meanings given below for R 2 and R 3 , respectively, or R 5 is a group of formula —Y—OH, where Y has the meaning described below in point (c); or (3) a group formula (III): in which R 4 has the meanings described above and R 10 is hydrogen or a linear or branched alkyl radical or an arylalkyl radical, in which, when R 10 is hydrogen, the resulting carboxylic group may optionally be salified with an organic or inorganic base to form a pharmaceutically acceptable salt; (b) R (c) R in which: Y is a linear or branched alkyl radical, optionally substituted with one or more phenyl groups, possibly substituted with one or more hydroxy and/or alkoxy groups; X is selected from: (1) the radical of a cycloalkyl-ether with a ring of from 3 to 7 members, possibly substituted and possibly comprising a one or two heteroatom; (2) a group of formula (V): in which R 11 is selected from: a linear or branched alkyl or alkenyl radical, possibly containing from 1 to 5 heteroatoms, which may be identical to one another or different, a monocyclic or polycyclic alkyl radical, an arylalkyl radical, an aryl radical or a heterocyclic radical which is aromatic or completely or partially saturated, having one or more heteroatoms, the radicals optionally being substituted with one or more groups selected from hydroxy, amino, acylamino, keto, ureide, guanidino, nitro, alkoxy, halogen, —O—PO 3 H 2 , —O—PO 2 H 2 , —O—SO 3 H, —SO 3 H, azido, —NHR 9 , —NR 7 R 8 , —N + R 7 R 8 R 9 Z − , in which Z − is the anion of a pharmaceutically acceptable organic or inorganic acid and R 7 , R 8 and R (3) a group of formula (VI): in which: (i) R R (4) a group of formula (VII): in which R 14 is selected from: a linear or branched alkylene or arylalkylene radical, possibly substituted with a hydroxy group or —O—CO—R 15 , in which R 15 is an alkyl, alkenyl or arylalkyl radical, R 7 , R 8 and R 9 are as defined above, or R 7 and R 8 may form, together with the nitrogen atom to which they are bound, a ring of from 3 to 7 members as defined above, and Z − is a pharmaceutically acceptable inorganic or organic anion; and (5) a group of formula (VIII): in which the —SO 3 − group may be in the ortho, meta or para position relative to the keto group, and M + is a pharmaceutically acceptable inorganic or organic cation.