Patent ID: 6566337
Filing Date: 2003-05-20
Classification: A61K,C07K

Abstract:
A compound of formula I whereinR1 and R2 are independently hydrogen or C1-6-alkyl optionally substituted with aryl; a and b are independently 1 or 2; G is J is wherein R27, R28, R29, R30, R31, R32, R33, R34, R35, and R36 independently are hydrogen, halogen, aryl, C1-6-alkyl or C1-6-alkoxy; D is R7â€”NHâ€”(CR8R9)pâ€”(CH2)mâ€”Mâ€”(CHR10)qâ€”(CH2)nâ€”wherein R7, R8, R9 and R10 are independently hydrogen or C1-6 alkyl optionally substituted with halogen, amino, hydroxyl or aryl; R7 and R8 or R7 and R9 or R8 and R9 may optionally form â€”(CH2)iâ€”Uâ€”(CH2)jâ€”, wherein i and j are independently are 1 or 2 and U is â€”Oâ€”, â€”Sâ€” or a valence bond; m and n are independently 0, 1, 2, or 3; p and q are independently 0 or 1; M is â€”CR11&boxH;CR11aâ€”, arylene, â€”Oâ€”, or â€”Sâ€”; R11 and R11a are independently hydrogen, or C1-6-alkyl optionally substituted with aryl; E is â€”CONR12R13, whereinR12 is C1-6-alkyl; R13 is hetaryl or C1-6-alkyl substituted with hetaryl; or a pharmaceutically acceptable salt thereof.