Patent ID: 9089539
Filing Date: 2015-07-28
Classification: A61K,A61P

Abstract:
1. A method of treating diabetes, said method comprising administering an effective amount of a pharmaceutical composition comprising an insulin polypeptide, said polypeptide comprising an A chain; a B chain; and a dipeptide of the formula wherein said A chain comprises a sequence of X 5 IVX 6 QCCX 7 SICSLYQLENYCX 8 (SEQ ID NO: 626), and said B chain comprises a sequence of X 13 LCGX 9 X 10 LVEALX 11 LVCGERGFX 12 (SEQ ID NO: 628), and said dipeptide is linked via an ester bond to the N-terminus, or a side chain of an amino acid located at position 1, 4 or 21 of SEQ ID NO: 626 or at the N-terminus, or a side chain of an amino acid at position 1, 5, 12 or 21 of SEQ ID NO: 628; further wherein X X X X X X X X R R