Patent ID: 6124333
Filing Date: 2000-09-26
Classification: C07C,C07D

Abstract:
A compound of formula (II) ##STR25## wherein R.sub.1 represents hydrogen or the side chain of a natural alpha amino acid in which any functional group may be protected, ora (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, phenyl or substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl or substituted phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl or substituted heterocyclyl, heterocyclyl(C.sub.1 -C.sub.6)alkyl or substituted heterocyclyl(C.sub.1 -C.sub.6)alkyl group;a group BSO.sub.n A-- whereinn is 0, 1 or 2 andB is hydrogen or a (C.sub.1 -C.sub.6)alkyl, phenyl, substituted phenyl, heterocyclyl, substituted heterocyclyl, (C.sub.1 -C.sub.6)acyl, phenacyl or substituted phenacyl group, andA represents (C.sub.1 -C.sub.6)alkyl;an amino(C.sub.1 -C.sub.6)alkyl;hydroxy(C.sub.1 -C.sub.6)alkyl, mercapto(C.sub.1 -C.sub.6)alkyl or carboxy(C.sub.1 -C.sub.6)alkyl wherein the amino-, hydroxy-, mercapto- or carboxyl-group are optionally protected or the carboxyl-group amidated;R.sub.2 represents a group Z.sup.1 --Q--W-- where Z.sup.1 represents hydrogen or an optionally substituted aryl, heterocyclyl, cycloalkyl, or cycloalkenyl group, and(i) (except when Z.sup.1 is 4-methoxyphenyl) --Q--W-- taken together represent a bond or(ii) (except when Z.sup.1 is hydrogen) Q represents --O-- or --S-- and W represents a divalent C.sub.1 -C.sub.20 straight or branched alkyl or C.sub.2 -C.sub.20 alkenyl group which(a) may be interrupted by one or more non-adjacent ether or thioether linkages or --N(R.sub.x)-- groups wherein R.sub.x is hydrogen, or C.sub.1 -C.sub.6 alkyl, and/or(b) may carry one or more substituents selected from --OH, --SH, --O(Alk), --S(Alk), halogen, --NH.sub.2, --NH(Alk), --N(Alk).sub.2, --CO.sub.2 H, --CO.sub.2 (Alk), --CO(Alk), --CHO, --CONH.sub.2, --CONH(Alk), --CON(Alk).sub.2, --(Alk)OH, --(Alk)SH, and --NHCO(Alk) where Alk represents C.sub.1 -C.sub.6 alkyl, or(iii) Q represents a bond and W represents a divalent C.sub.9 -C.sub.20 straight or branched alkyl or C.sub.2 -C.sub.20 alkenyl group which(a) may be interrupted by one or more non-adjacent ether or thioether linkages or --N(R.sub.x)-- groups wherein R.sub.x is hydrogen, or C.sub.1 -C.sub.6 alkyl, and/or(b) may carry one or more substituents selected from --OH, --SH, --O(Alk), --S(Alk), halogen, --NH.sub.2, --NH(Alk), --N(Alk).sub.2, --CO.sub.2 H, --CO.sub.2 (Alk), --CO(Alk), --CHO, --CONH.sub.2, --CONH(Alk), --CON(Alk).sub.2, --(Alk)OH, --(Alk)SH, and --NHCO(Alk) where Alk represents C.sub.1 -C.sub.6 alkyl, or(iv) Q represents a bond and W represents a divalent C.sub.1 -C.sub.8 straight or branched alkyl group which(a) carries one or more substituents selected from --SH, --CO.sub.2 H, --CO.sub.2 (Alk), --CHO, --CONH.sub.2, --CONH(Alk), ---CON(Alk).sub.2, and --(Alk)SH, where Alk represents C.sub.1 -C.sub.6 alkyl, and(b) (in the case where W is C.sub.2 -C.sub.8) may be interrupted by one or more non-adjacent ether or thioether linkages or --N(R.sub.x)-- groups wherein R.sub.x is hydrogen, or C.sub.1 -C.sub.6 alkyl; andZ represents an optionally substituted heteroaryl group;or a salt, hydrate or solvate thereof.