Patent ID: 8227193
Filing Date: 2012-07-24
Classification: C07H,C07K,G01N

Abstract:
1. A method for identifying one or more test compounds that alters binding of RelB Rel homology domain (RelB RHD) with RelBκB sequence, comprising: a) providing b) contacting said isolated nucleotide sequence with said polypeptide in the presence and absence of said one or more test compounds; and determining the level of specific binding of said nucleotide sequence with said polypeptide in the presence of said one or more test compounds compared to in the absence of said one or more test compounds, wherein detecting altered specific binding of said nucleotide sequence with said polypeptide in the presence of said one or more test compounds compared to in the absence of said one or more test compounds identifies said one or more test compounds as altering binding of RelB RHD with RelBκB sequence.