Patent ID: 6191277
Filing Date: 2001-02-20
Classification: C07C,C07D,Y02A

Abstract:
A compound of Formula I: ##STR55##wherein:R.sup.1 is selected from the group consisting of alkyl, and --(CH.sub.2).sub.n -cycloalkyl and where n=1-3;R.sup.2 is H or [S]--C(O)--L--, wherein [S] is a solid support and --L-- is a linker;Y is --OC(O)NHR.sup.3 or --NR.sup.4 R.sup.5, wherein R.sup.3 is alkyl, aralkyl, aryl or aryloxyalkyl;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, alkoxyalkyl, R.sup.3, --C(O)R.sup.3, --SO.sub.2 R.sup.3, ##STR56##wherein m=0-3; or when R.sup.4 and R.sup.5 together with the nitrogen atom to which they attach is ##STR57##where X=NR.sup.6 or O;R.sup.6 is selected from the group consisting of H, R.sup.3, --C(O)R.sup.3 and --SO.sub.2 R.sup.3 ;Z is selected from the group consisting of --C(O)R.sup.7, --C(O)CH(R.sup.8)OC(O)NHR.sup.3 and --C(O)CH(R.sup.8)NHC(O)R.sup.3 ; whereinR.sup.7 is selected from the group consisting of alkyl, aralkyl, aryl, --(CH.sub.2).sub.m -cycloalkyl, heteroaryl, ##STR58##andR.sup.8 is selected from the group consisting of H, alkyl, aralkyl and --(CH.sub.2).sub.m -cycloalkyl.