Patent ID: 6906026
Filing Date: 2005-06-14
Classification: A61K,A61P

Abstract:
1. A method for treating a condition associated with the excess accumulation of extracellular matrix in a tissue and/or organ or at a dermal wound site comprising: a) reducing the excess accumulation of extracellular matrix associated with TGFβ overproduction and/or activity in an organ or tissue, or at a wound site, by administering in an amount sufficient to inhibit TGFβ overproduction and/or activity, a first agent that reduces TGFβ-associated accumulation of extracellular matrix; and b) degrading excess accumulated extracellular matrix in said tissue and/or organ or wound site, by administering in an amount sufficient to degrade excess accumulated extracellular matrix, a different, second agent that degrades extracellular matrix; whereby the accumulation of extracellular matrix in said tissue and/or organ or wound site is reduced from the level existing at the time of treatment.