Patent ID: 8093269
Filing Date: 2012-01-10
Classification: A61P,C07D

Abstract:
1. A 3-benzylidene-anabaseine of the formula: where R 1 is, independently, acetoxy, acetamido, amino, dimethylcarbamoyl, diethylcarbamoyl, methylcarbamoyl, ethylcarbamoyl, difluoromethoxy, diethylaminopropoxy, trimethylammoniumpropoxy, trimethylammoniumpentoxy, C 1 -C 3 alkyl, C 1 -C 3 alkylhydroxy, hydroxyl, C 1 -C 3 alkoxy, trifluoromethoxy, methylamino or thiomethoxy and n is 0-5; R 2 is independently C 1 -C 3 alkyl and n′ is 1-3, wherein at least one R 2 is present at position 4, 5, or 6; R 3 is independently C 1 -C 3 alkyl, C 1 -C 3 alkylhydroxy, C 1 -C 3 alkoxy, cyano, halo, phenoxy, phenyl, pyridyl or benzyl and n″ is 0-4; R 4 is hydrogen or C 1 -C 3 alkyl or C 1 -C 3 alkylhydroxy; or a pharmaceutically acceptable salt, clathrate, stereoisomer, enantiomer, or combination thereof.