Patent ID: 7238371
Filing Date: 2007-07-03
Classification: A61K,C08G

Abstract:
1. A method of releasing a therapeutic agent from a proteinoid microsphere comprising introducing a therapeutic agent encapsulated with a proteinoid microsphere comprising a mixture of amino acids that are thermally condensed and crosslinked with a crosslinker of any one of the formulae I-VI into a reducing environment: wherein: X is a spacer group of about 3 to 100 angstroms by about 2 to 30 angstroms that comprises an alkane chain, an alkene chain, a cycloalkyl or aryl ring having five to fourteen carbon atoms, or a combination thereof; n is an integer ranging from 1 to 18; S is a sulfur atom; and Aryl is a phenyl radical or an ortho-fused bicyclic radical having about nine to ten ring atoms wherein at least one ring is aromatic and wherein each Aryl moiety is substituted with at least one reactive group that can form a covalent linkage with an amino acid.