Patent ID: 6291459
Filing Date: 2001-09-18
Classification: A61P,C07D

Abstract:
A compound selected from Formula (I) hereinbelow: ##STR5##or a pharmaceutically acceptable salt thereof,wherein:m is an integer from 0 to 2;n is an integer from 1 to 3;X is selected from the group consisting of CN, NO.sub.2, Cl, F, and H;Y is selected from the group consisting of Cl, F, Br, I and H; andQ and Z are, independently, selected from the group consisting of H, R.sub.1, SO.sub.2 R.sub.1 ', R.sub.1 C(O)OR.sub.1 "", SO.sub.2 NR.sub.1 'R.sub.1 "", C(O)NR.sub.1 'R.sub.1 "", NR.sub.1 'SO.sub.2 R"".sub.1, wherein R1, R.sub.1 ' and R.sub.1 "" are independently selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.3-6 cycloalkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkynyl, heterocycloalkyl, aryl and aryl C.sub.1-4 alkyl; or R.sub.1 ' and R.sub.1 "" together form a 3 to 7 membered optionally substituted heterocyclic ring; wherein any substituents are selected from the group consisting of CN, aryl, CO.sub.2 R, CO.sub.2 NHR, OH, OR, NH.sub.2, halo, CF.sub.3, OCF.sub.3 and NO.sub.2 ; wherein R represents H, C.sub.1-4 alkyl, and C.sub.3-6 cycloalkyl; and A is phenyl or naphthyl, unsubstituted or substituted with any substituents being selected from the group consisting of OH, halo, CO.sub.2 R.sub.1, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.3-6 cycloalkyl, OSO.sub.2 R.sub.1, CN, NO.sub.2, OCF.sub.3, CF.sub.3, and CH.sub.2 CF.sub.3, (CH.sub.2).sub.n CO.sub.2 H, (CH.sub.2).sub.n CO.sub.2 R.sub.1, and O--(CH.sub.2).sub.n CO.sub.2 R.sub.1, wherein n is an integer from 0 to 3 0-3 and R.sub.1 represents C.sub.1-4 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl, heteroaryl or fused heteroaryl (wherein the hetero-ring contains N, O or S and is aromatic, dihydro or tetrahydro) unsubstituted or substituted with any substituents being selected from the group consisting of OH, OCH.sub.3, CH(CH.sub.3).sub.2, halo, CO.sub.2 R.sub.1, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.3-6 cycloalkyl, CN, NO.sub.2, OCF.sub.3, CF.sub.3, CH.sub.2 CF.sub.3, (CH.sub.2).sub.n CO.sub.2 R.sub.1, and O--(CH.sub.2).sub.n CO.sub.2 R.sub.1.