Patent ID: 6495711
Filing Date: 2002-12-17
Classification: C07B,C07C

Abstract:
A process for preparing a Compound of formula wherein R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, substituted aryl and aralkyl; comprising reacting (Â±)2-azabicyclo[2.2.1]hept-5-en-3-one of formula (II) with an alcohol of formula (III), R1OH, wherein R1 is as described above, and a non-aqueous acid, to form the corresponding Compound of formula (IV), wherein X is the corresponding acid anion; reacting the Compound of formula (IV) with L-tartaric acid and a tertiary amine, to form the corresponding Compound of formula (V); suspending the Compound of formula (V) in an organic solvent, and treating with a Compound of formula (VI), (R1OCO)2O, or a Compound of formula (VII), R1OC(O)Y, wherein Y is chlorine or bromine and wherein R1 is as set forth above, in the presence of a base, to form the corresponding Compound of formula (I).