Patent ID: 6211360
Filing Date: 2001-04-03
Classification: A61K,C07D

Abstract:
A compound having the formula: ##STR16##whereinn is from 0 to 8;R.sup.1 is CH.sub.2 OH, CH(OH)R.sup.5, CH.sub.2 OR.sup.5, CO.sub.2 R.sup.5, C(O)NH.sub.2, C(O)NHR.sup.5, C(O)NR.sup.5 R.sup.6, C(O)NHNH.sub.2, C(O)NHNHR.sup.5, C(O)NHNR.sup.5 R.sup.6, C(O)NR.sup.5 NH.sub.2, C(O)NR.sup.5 NHR.sup.6, C(O)NR.sup.5 NR.sup.6 R.sup.7, C(O)NHNH(C(O)R.sup.5), C(O)NHNR.sup.5 (C(O)R.sup.6), C(O)NR.sup.5 NH(C(O)R.sup.6), C(O)NR.sup.5 NR.sup.6 (C(O)R.sup.7), or C(O)R.sup.5 ;R.sup.2 is H, unsubstituted or substituted alkyl, YH, YR.sup.8, YC(O)R.sup.8, C(O)YR.sup.8, C(O)NH.sub.2, C(O)NHR.sup.8, C(O)NR.sup.8 R.sup.9, NH.sub.2, NHR.sup.8, NR.sup.8 R.sup.9, NHC(O)R.sup.8, NR.sup.8 C(O)R.sup.9 ;R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of H, halogens, unsubstituted or substituted alkyl, OH, OR.sup.10, NH.sub.2, NHR.sup.10, NR.sup.10 R.sup.11, NHC(O)R.sup.10, or NR.sup.10 C(O)R.sup.11 ;R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 are the same or different and are selected from the group consisting of unsubstituted alkyl and substituted alkyl;R.sup.12 is selected from the group consisting of H, unsubstituted alkyl, and substituted alkyl; andY is O or S;provided that when n is 0, R.sup.2 is substituted alkyl other than CH(OH)CH.sub.3 ;further provided that when n is 2, R.sup.2 is OH, R.sup.12 is H, and both R.sup.3 and R.sup.4 are H, R.sup.1 is not CO.sub.2 CH.sub.3 ; andfurther provided that when n is 2, R.sup.2 is H, R.sup.12 is H, and R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of H and OCH.sub.3, R.sup.1 is not CO.sub.2 CH.sub.3 ;or a pharmaceutically acceptable salt thereof.