Patent ID: 8999389
Filing Date: 2015-04-07
Classification: A61K,A61P

Abstract:
1. A method for preparing a ceramic composition for controlled release of a pharmaceutically active substance, comprising the steps of: i) mixing one or more hydratable and bioresorbable ceramics with one or more pharmaceutically active substances, ii) densifying the mixture obtained in i) by applying an external pressure, and iii) hydrating the ceramic during the densification in step ii) by adding water to the resulting mixture from step i) in an amount corresponding to from about 20% to about 120% of the stoichiometric amount necessary to fully hydrate the one or more ceramics, whereby a highly densified and at least partly hydrated ceramic is obtained with a porosity of below 7%, wherein the applied external pressure in step ii) is of at least 20 MPa for at least 10 minutes.