Patent ID: 6657058
Filing Date: 2003-12-02
Classification: C07D

Abstract:
A process of synthesizing a compound of Formula I whereinR1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from acyl, acyloxy, optionally substituted alkenyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkynyl, optionally substituted amino, optionally substituted aryl, optionally substituted aryloxy, carboxyl, (optionally substituted alkoxy)carbonyl, (optionally substituted amino)carbonyl, (optionally substituted alkoxy)carbonyloxy, (optionally substituted amino)carbonyloxy, cyano, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, halogen, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclooxy, hydrogen, hydroxyl, nitro, optionally substituted azo, Sâ€”R31, SOâ€”R31, and SO2â€”R31, R9 and R10 are independently selected from H, acyl, acyloxy, optionally substituted alkenyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkynyl, optionally substituted amino, optionally substituted aryl, optionally substituted aryloxy, carboxyl, (optionally substituted alkoxy)carbonyl, (optionally substituted amino)carbonyl, (optionally substituted alkoxy)carbonyloxy, (optionally substituted amino)carbonyloxy, cyano, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, fluoro, chloro, bromo, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclooxy, hydrogen, hydroxyl, nitro, optionally substituted azo, sulfanyl, sulfinyl, and sulfonyl,; R23 and R24 independently at each occurrence are selected from H, OH, optionally substituted C1-4 alkyl, optionally substituted C3-10 cycloalkyl, halogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl; R31 represents acyl, optionally substituted alkenyl, optionally substituted alky, optionally substituted alkoxy, optionally substituted alkoxycarbonyl, optionally substituted alkynyl, optionally substituted aminocarbonyl, optionally substituted aryl, carboxy, optionally substituted cycloalkyl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; and X represents a charge balancing species (counter ion) selected from halide, NO2âˆ’2, â€”OCOCH3, PF6âˆ’1, BF4âˆ’1, COO-1, and SO4âˆ’2â€”; said process comprisingtreating, in an inert medium and in the presence of an organic base, a compound of formula A with an organo metallic agent capable of acting as an outer sphere oxidant to form a compound of Formula I.