Patent ID: 6100377
Filing Date: 2000-08-08
Classification: A61K,A61P,C07K

Abstract:
A constrained peptide having the formula:R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 -R.sub.5 -R.sub.6 -R.sub.7wherein:R.sub.1 is 1-5 amino acid residues, at least one of which is tyrosine or phenylalanine;R.sub.2 is a linking amino acid residue;R.sub.3 is 0 amino acid;R.sub.4 is an amino acid sequence comprising 3-8 amino acids, wherein the amino acid sequence is identical to the amino acid sequence of a complementarity determining region or a complementarity determining region-like structure of an immunoglobulin superfamily member;R.sub.5 is 0 amino acid;R.sub.6 is a linking amino acid residue;R.sub.7 is 1-5 amino acid residues, at least one of which is tyrosine or phenylalanine;wherein:R.sub.2 and R.sub.6 are linked to each other to form a cyclic portion of said constrained peptide consisting of R.sub.2 -R.sub.3 -R.sub.4 -R.sub.5 -R.sub.6 ;and R.sub.1 and R.sub.7 are exocyclic.