Patent ID: 8557515
Filing Date: 2013-10-15
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method of diagnosing an miR16-mediated B-cell chronic lymphocytic leukemia in a subject, comprising the steps of: (i) obtaining a test sample containing B-lymphocytes from the subject, (ii) measuring the level of an miR16 gene product that comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:4 in the test sample, (iii) comparing the level of the miR16 gene product in the test sample to a control level of the miR16 gene product in a control miR16 gene product sample, and (iv) determining the subject has an miR16-mediated B-cell chronic lymphocytic leukemia by detecting a lower level of the miR16 gene product in the test sample, relative to the control miR16 gene product sample.