Patent ID: 8673361
Filing Date: 2014-03-18
Classification: A61K,A61P

Abstract:
1. A method of increasing or decreasing cytokine levels or activity in an isolated human cell, said method comprising contacting the cell with an effective amount of a composition said composition comprising a mixture of denatured plasma protein and at least one metal ion or metal salt, wherein said composition is produced by: (a) mixing isolated plasma with sodium bicarbonate (NaHCO (b) isolating and resolubilising said precipitate in the presence of an aqueous solution at a temperature of between about 80° C. and about 150° C., wherein either before, during or after the resolubilising step at least one metal ion or metal salt thereof is admixed and wherein said cytokines are selected from the group consisting of tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), tumour necrosis factor alpha converting enzyme (TACE), macrophage-inflammatory protein 1 alpha (MIP-1α), cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2).