Patent ID: 6046167
Filing Date: 2000-04-04
Classification: A61K,C07C,C07K,Y02A

Abstract:
A compound selected from the group consisting of:N-.alpha.-R.sup.1 -[Nle.sup.24,28,30, Trp.sup.27, Nva.sup.31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Nle.sup.24,28, Trp.sup.27,30, Nva.sup.31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Nle.sup.24,28,30, Phe.sup.27, Nva.sup.31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Nle.sup.24,28, Phe.sup.27, Trp.sup.30, Nva.sup.31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Trp.sup.30, .psi..sup.35/36 ]PYY(25-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Trp.sup.30 ]PYY(25-36)-NH.sub.2,N-.alpha.-R.sup.1 -[Nle.sup.24,28, Trp.sup.30, Nva.sup.31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2 andN-.alpha.-R.sup.1 -[Nle.sup.28, Trp.sup.30, Nva31, .psi..sup.35/36 ]PYY(22-36)-NH.sub.2 or a pharmaceutically-acceptable salt thereof,wherein R.sup.1 is H, (C.sub.1 -C.sub.12)alkyl or (C.sub.1 -C.sub.12)acyl; and.psi. is a pseudopeptide bond selected from the group consisting of --CH.sub.2 --NH--, --CH.sub.2 --S--, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O-- and --CH.sub.2 --CO--.