Patent ID: 8940332
Filing Date: 2015-01-27
Classification: A61K,A61P,C08G,C08L

Abstract:
1. A high-molecular weight conjugate of podophyllotoxins, represented by formula (I): wherein R1 represents a hydrogen atom or a (C1-C6) alkyl group; R2 represents a linking group; R3 represents a hydrogen atom or a (C1-C6) acyl group; R4 represents the residue of a hydroxyl group of the podophyllotoxins; R5 represents a group selected from the group consisting of a (C1-C30) alkoxy group, a (C7-C30) aralkyloxy group, a (C1-C30) alkylamino group, a di(C1-C30) alkylamino group, an amino acid with a protected carboxyl group, and —N(R6)CONH(R7) wherein R6 and R7, which may be identical or different, each represent a (C3-C6) cyclic alkyl group or a (C1- C5) alkyl group optionally substituted with a tertiary amino group; t represents an integer from 5 to 11,500; d, e, f, g, h, i and j each independently represent an integer from 0 to 200, provided that d+e represents an integer from 1 to 200, and d+e+f+g+h+i+j represents an integer from 3 to 200, and that the respective constituent units of polyaspartic acid are bound in any order.