Patent ID: 7569592
Filing Date: 2009-08-04
Classification: A61P,C07D

Abstract:
1. A compound which is selected from the group consisting of: 3-(4-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-[1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyridine; 3-(1-pyridin-2-yl-1H-pyrazol-4-yl)benzonitrile; 2-[4-(3-methoxyphenyl)-1H-pyrazol-1-yl]pyridine; 3-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 3-(1-pyridin-2-yl-1H-pyrazol-3-yl)benzonitrile; 2-[1-(3-bromophenyl)-1H-pyrazol-4-yl]pyridine; 3-fluoro-5-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 3-fluoro-5-(5-methyl-3-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-[1-(2,5-difluorophenyl)-1H-pyrazol-3-yl]pyridine; 3-(3,5-dimethyl-4-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-[1-(2,3,5,6-tetrafluoro-phenyl)-1H-pyrazol-3-yl]pyridine; 2-[1-(3,5-difluoro-phenyl)-1H-pyrazol-3-yl]-pyridine; 2-(1-pentafluorophenyl-1H-pyrazol-3-yl)-pyridine; 2-[1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-pyridine; 2-[1-(2,3,5,6-tetrafluoro-4-methyl-phenyl)-1H-pyrazol-3-yl]-pyridine; 2-[1-(3-nitro-phenyl)-1H-pyrazol-3-yl]-pyridine; 3-fluoro-5-(4-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-{1-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-1H-pyrazol-4-yl}pyridine; 4-(4-pyridin-2-yl-1H-pyrazol-1-yl)pyridine-2-carbonitrile; 2-[1-(4-nitro-phenyl)-1H-pyrazol-3-yl]-pyridine; 3-(1-pyridin-2-yl-1H-pyrazol-3-yl)benzonitrile; 2-[4-(3-methylphenyl)-1H-pyrazol-1-yl]pyridine; 2-[1-(3-fluoro-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3,4-dimethyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(4-phenoxy-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3-methoxy-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(2-benzyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(4-isopropoxy-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3-ethyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(2-fluoro-5-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3-tert-butyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(2,3,5-trifluorophenyl)-1H-pyrazol-3-yl]pyridine; 3-(3-pyridin-2-yl-1H-pyrazol-1-yl)-5-(trifluoromethyl)benzonitrile; 3-[(5-chloropyridin-3-yl)oxy]-5-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-(3-pyridin-2-yl-1H-pyrazol-1-yl)isonicotinonitrile; 2-[1-(3,5-dibromophenyl)-1H-pyrazol-3-yl]pyridine; 3-bromo-5-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzonitrile; 2-{4-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-1H-pyrazol-1-yl}pyridine; 2-[1-(3-bromo-5-fluorophenyl)-1H-pyrazol-3-yl]pyridine; 3-[(3-pyridin-2-yl-1H-pyrazol-1-yl)methyl]benzonitrile; 2-[1-(2,4-difluorophenyl)-1H-pyrazol-3-yl]pyridine; 4-[(4-pyridin-2-yl-1H-pyrazol-1-yl)methyl]benzonitrile; 3-[(4-pyridin-2-yl-1H-pyrazol-1-yl)methyl]benzonitrile; 6-(4-pyridin-2-yl-1H-pyrazol-1-yl)nicotinonitrile; 2-[(4-pyridin-2-yl-1H-pyrazol-1-yl)methyl]benzonitrile; 2-[1-(3,5-bis-trifluoromethyl-phenyl)-1H-pyrazol-3-yl]-pyridine; 2-[4-(4-fluorophenyl)-1H-pyrazol-1-yl]pyridine; 4-(1-pyridin-2-yl-1H-pyrazol-4-yl)benzonitrile; 2-{4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}pyridine; 2-{4-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}pyridine; 2-[4-(3-fluorophenyl)-1H-pyrazol-1-yl]pyridine; 2-[1-(3-bromo-4-methylphenyl)-1H-pyrazol-4-yl]pyridine; 2-[1-(4-bromo-3-methyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(4-sec-butyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(4-propyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(4-cyclohexyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2,2-dimethyl-propionic acid 4-(4-pyridin-2-yl-pyrazol-1-yl)-phenyl ester; 2,2-dimethyl-propionic acid 4-(4-pyrimidin-4-yl-pyrazol-1-yl)-phenyl ester; 2-[1-(2-propyl-phenyl)-1H-pyrazol-4-yl]-pyridine; dimethyl-carbamic acid 4-(4-pyridin-2-yl-pyrazol-1-yl)-phenyl ester; 2-[1-(2,6-dimethyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(2-fluoro-4-methyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 2-[1-(3-bromo-2-methyl-phenyl)-1H-pyrazol-4-yl]-pyridine; 4-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzoic acid; 2-{1-[3-(pyridin-4-yloxy)phenyl]-1H-pyrazol-3-yl}pyridine; 2-(3-pyridin-2-yl-1H-pyrazol-1-yl)-5-(trifluoromethyl)pyridine; 2-(1-phenyl-1H-pyrazol-3-yl)pyridine; 3-(3-pyridin-2-yl-1H-pyrazol-1-yl)benzoic acid; 2-{1-[3-fluoro-5-(pyridin-4-ylthio)phenyl]-1H-pyrazol-3-yl}pyridine; and 2-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-3-yl}pyridine; or a pharmaceutically acceptable salt thereof.