Patent ID: 9211317
Filing Date: 2015-12-15
Classification: A61K,A61P,C12N

Abstract:
1. Method of facilitated percutaneous coronary intervention (PCI) for treating patients with acute myocardial infarction (AMI) comprising: within 6 hrs after a patient is afflicted with AMI, firstly, performing thrombolytic therapy with the proUK or variants thereof, whereas the variant of proUK is proUKs having a lysine (Lys) at position 300 in the amino acid sequence of the proUK as shown in SEQ ID No.1 site-mutated into histidine (His); then, performing the PCI operation, to dredge the infarction related artery (IRA) as soon as possible, and re-establish an effective forward blood flow, such that an ischemic myocardium is reperfused.