Patent ID: 7060868
Filing Date: 2006-06-13
Classification: A01K,A61K,C07K

Abstract:
1. A method for producing a mouse recipient that produces an antibody reactive to an antigen protein for an autoimmune disease and/or has activated T cells reactive to the antigen protein, which comprises the steps of: (a) immunizing, with the antigen protein for the autoimmune disease, a mouse donor that (i) lacks a gene encoding the antigen protein and (ii) develops immune cells, (b) preparing immune cells from the donor, and (c) transplanting the immune cells to the recipient that (iii) is the same species as the donor, and (iv) has the same genetic background and/or is immunodeficient, thereby producing a mouse recipient that produces an antibody reactive to an antigen protein for an autoimmune disease and/or has activated T cells reactive to the antigen protein, wherein the antigen protein is desmoglein 3 protein and the autoimmune disease is