Patent ID: 8183415
Filing Date: 2012-05-22
Classification: A61P,C07C

Abstract:
1. A method for the preparation of cinacalcet, a cinacalcet derivative, or a salt thereof, comprising: a) admixing a compound of formula (VIII) and a compound of formula (XI), under conditions that promote coupling of compound (VIII) and compound (XI) to form compound (XII) wherein X is selected from the group consisting of chlorine, bromine, iodine, OSO 2 C 6 H 4 CH 3 , OSO 2 CH 3 , OSO 2 CF 3 , OSO 2 C 4 F 9 and N 2 + , and R is selected from the group consisting of hydrogen, benzyl, substituted benzyl, BOC, CBZ, and acetate; and b) reducing compound (XII) under conditions that permit reduction to form cinacalcet, a cinacalcet derivative, or a salt thereof.