Patent ID: 6696289
Filing Date: 2004-02-24
Classification: A61K,C07K,C12N,Y02A

Abstract:
A replication-competent, genetically stable, recombinant Sabin type I poliovirus vector which comprises:(a) nucleotides 1-745 of SEQ ID NO: 1, wherein positions 743-745 are ATG; (b) a multiple cloning site directly linked 3â€² to said ATG; (c) a 3C-protease cleavage site coding for the amino acid sequence of Ala-Leu-Phe-Gln (SEQ ID NO: 30) which is directly linked 3â€² to said multiple cloning site; and (d) nucleotides 746 to7440 of SEQ ID NO: 1.