Patent ID: 7847107
Filing Date: 2010-12-07
Classification: A61P,C07B,C07D

Abstract:
1. A method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which comprises catalytically reducing 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound represented by the following general formula (I): wherein R 1 represents a linear or branched alkyl group having 1 to 10 carbon atoms which may be substituted, a cycloalkyl group which may be substituted, an aralkyl group which may be substituted, or an aryl group which may be substituted; R 2 and R 3 each independently represent an aryl group which may be substituted; and the mark * in the pyrrolidine ring indicates that the carbon atom at that position has the S configuration, and a rhodium compound.