Patent ID: 6498150
Filing Date: 2002-12-24
Classification: A61K,A61P,C07C,C07F,Y02A,Y10S

Abstract:
A compound of the formula (I): wherein:A is a group of the formula â€”PO3H, â€”SO3H, â€”OPOâ€”(OH)2â€”OSO2OH, or â€”SH, or pharmaceutically acceptable salt thereof or physiologically hydrolyzable derivative thereof, R1 is H, a linear or branched lower alkyl, an arylalkyl or an alkenyl, R2 is H, a linear or branched lower alkyl, an alkenyl, an arylalkyl, an acyl, a carbonate ester, an allyloxy carbonyl, a cycloalkoxycarbonyl, an unsubstituted arylalkoxycarbonyl or a substituted arylalkoxycarbonyl, or R1 and R2 taken together form, with the nitrogen to which they are attached, a 5 to 7 membered ring, and L1 and L2 are, independently, a hydrocarbon linking group, a cycloalkyl, or an interphenylene, with the provisos that the compound of formula I is 4-amino N-(2-mercaptoethyl)butanamide, or 3-amino N-(3-mercaptopropyl)propionamide;or pharmaceutically acceptable salt thereof, unionized form thereof and at least one of R1 and R2 is an alkyl or at least one L1 and L2 is not â€”(CH2)2â€” or â€”(CH2)3â€”.