Patent ID: 7005428
Filing Date: 2006-02-28
Classification: A61K

Abstract:
1. A method of treating or reducing the risk of acquiring hypercholesterolemia comprising administering to a patient in need of such treatment or reduction a therapeutically effective amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androst-5-ene-3β,17β-diol and a compound converted in vivo to one of the foregoing, and further comprising administering to said patient a therapeutically effective amount of a selective estrogen receptor modulator as part of a combination therapy, wherein said selective estrogen receptor modulator is a benzopyran derivative of the following general structure:  wherein D is —OCH wherein R wherein a beneficial effect of said combination exceeds by a statistically significant margin, a beneficial effect from either said precursor or said selective estrogen receptor modulator alone.