Patent ID: 6344478
Filing Date: 2002-02-05
Classification: A61K,C07C,Y10S

Abstract:
A method of treating glaucoma and ocular hypertension which comprises topically administering to the affected eye a composition comprising a therapeutically effective amount of a combination of a carbonic anhydrase inhibitor together with a compound having the absolute stereochemical structure of the following formula (IV): wherein:R1=H; C1-C12 straight-chain or branched alkyl; C1-C12 straight-chain or branched acyl; C3-C8 cycloalkyl; or a cationic salt moiety; R2, R3&boxH;H, or C1-C5 straight-chain or branched alkyl; or R2 and R3 taken together may represent O; X&boxH;O, S, or CH2; ---- represents any combination of a single bond, or a cis or trans double bond for the alpha (upper) chain; and a single bond or trans double bond for the omega (lower) chain; R9=H, C1-C10 straight-chain or branched alkyl, or C1-C10 straight-chain or branched acyl; R11=H, C1-C10 straight-chain or branched alkyl, or C1-C10 straight-chain or branched acyl; Y=O; or H and OR15 in either configuration wherein R15=H, C1-C10 straight-chain or branched alkyl, or C1-C10 straight-chain or branched acyl; and Z=Cl or CF3; with the proviso that when R2 and R3 taken together represent O, then R1â‰ C1-C12 straight-chain or branched acyl; and when R2=R3=H, then R1â‰ a cationic salt moiety.