Patent ID: 7943768
Filing Date: 2011-05-17
Classification: A61P,C07D

Abstract:
1. A compound of Formula I or a pharmaceutically acceptable salt thereof wherein P is a monocyclic or bicyclic C W is a piperazine or homopiperazine ring optionally substituted on any ring carbon atom by group independently selected from C X is two hydrogen atoms each linked by a single bond to the carbon atom in —C(═X); and Q is a 4-7 membered aliphatic ring comprising one nitrogen atom and Q is linked to —C(═X)— via a ring carbon atom, such aliphatic ring being (i) optionally monosubstituted on the ring nitrogen atom by a C (ii) optionally monosubstituted on the nitrogen atom by a monocyclic (hetero)aliphatic or (hetero)aromatic ring of up to 7 ring atoms and comprising up to three heteroatoms each independently selected from N, O or S and the ring being optionally substituted by 1, 2 or 3 substituents independently selected from halogen, C (iii) optionally substituted on the ring nitrogen atom by a (hetero)aryl-C (iv) optionally substituted on the ring nitrogen atom by a straight or branched chain alkyl group of up to 8 (such as up to 6) carbon atoms optionally comprising a double or treble carbon-carbon bond and further optionally substituted by up to 2 substituents independently selected from hydroxy, CF (v) optionally mono-substituted on one or more ring carbon atoms by halogen, —CN or a C (vi) optionally disubstituted on ring carbon atom by C provided that formula 1 is not (i) 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine; (ii) 4-(4((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)-1H-indole, or (iii) 1-(2-methoxyphenyl)-4-(piperidin-3-ylmethyl)piperazine.