Patent ID: 7709481
Filing Date: 2010-05-04
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein B is C(R4)or N; R1 is selected from the group consisting of H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, (C3-C7) cycloalkyl, SCH R2, R3 and R4 are independently selected from the group consisting of: R2 and R3 together with the carbon atoms to which they are bonded form a (C6-C10) aryl or a (C5-C10) heteroaryl ring; X is selected from the group consisting of O, S, S(O), S(O) one of U and V is N and the other is S or O; W is a bond, (C1-C8) alkylene, or (C2-C8) alkenylene, wherein the alkylene and alkenylene are optionally mono-, di- or tri-substituted by OH or F; Y is a bond, O, S, S(O), S(O) R5 is selected from the group consisting of H, (C1-C8) alkyl, (C0-C4) alkylene-(C3-C13) cycloalkyl, (C0-C4) alkylene-(C6-C14) aryl, (C2-C8) alkenyl, (C0-C4) alkylene-(C3-C15) heterocycloalkyl, (C0-C4) alkylene-(C3-C15) heterocycloalkenyl, and (C0-C4) alkylene-(C5-C15) heteroaryl, wherein the alkyl and alkylene are optionally mono-, di- or tri-substituted by (C1-C4) alkyl or O—(C0-C4) alkylene-H, and are optionally substituted one to five times by F, and wherein the cycloalkyl, aryl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are optionally mono-, di- or tri-substituted by F, Cl, Br, CF R6 is selected from the group consisting of H, (C1-C8) alkyl and (C2-C8) alkenyl, wherein the alkyl and alkenyl are optionally mono-, di- or tri-substituted by F or O—(C0-C4)-alkylene-H, or R5 and R6 together with the nitrogen atom to which they are bonded form a (C3-C9)-heterocycloalkyl, a (C3-C9)-heterocycloalkenyl or a (C5-C9)-heteroaryl, each of which can contain additionally 1 to 3 heteroatoms selected from N, O, and S, and each of which is optionally mono-, di- or tri-substituted by F, CF Z is a bond, (C1-C8) alkylene, (C2-C8) alkenylene, (C2-C8) alkylidene, or (C1-C6) alkylene-O—(C1-C6) alkyl; A is selected from the group consisting of (C3-C13) cycloalkyl, (C4-C15) heterocycloalkyl, (C4-C15) heterocycloalkenyl and (C5-C15) heteroaryl ring; R7 and R8 are independently selected from the group consisting of H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, SCF R9 and R10 are independently selected from the group consisting of H, (C1-C6) alkyl, (C2-C6) alkenyl, (C0-C6) alkylene-(C6-C14) aryl, (C0-C6) alkylene-(C5-C15) heteroaryl, (C0-C6) alkylene-(C3-C8) cycloalkyl, and (C0-C6) alkylene-(C3-C8) cycloalkenyl, wherein the alkyl and alkylene are optionally mono-, di- or tri-substituted by F, and wherein the aryl and heteroaryl are optionally mono-, di- or tri-substituted by halogen, (C1-C4) alkyl or O—(C1-C4) alkyl; or a stereoisomeric form thereof or a mixture in any ratio thereof, or a physiologically acceptable salt or a tautomer thereof.