Patent ID: 6521740
Filing Date: 2003-02-18
Classification: A61K,C07K

Abstract:
An isolated and purified Type II IL-1 receptor (Type II IL-1R) that binds IL-1, and is encoded by a DNA that hybridizes under moderately stringent conditions with a DNA selected from the group consisting of:(a) a DNA encoding a Type II IL-1R having an amino acid sequence as set forth in SEQ ID NO.: 2, having an amino terminus at amino acid 1, and a carboxy terminus selected from the group consisting of an amino acid between amino acids 330 and 385, inclusive, of SEQ ID NO.:2; (b) a DNA encoding a Type II IL-1R having an amino acid sequence as set forth in SEQ ID NO:13, having an amino terminus at amino acid 1, and a carboxy terminus selected from the group consisting of an amino acid between amino acids 342 and 397, inclusive, of SEQ ID NO.:13; and (c) a DNA encoding a fragment of the polypeptide of (a) or (b), which fragment binds IL-1.