Patent ID: 7470711
Filing Date: 2008-12-30
Classification: A61P,C07D

Abstract:
1. A compound or the pharmaceutically acceptable salts, hydrates, stereoisomers, crystalline or amorphous forms thereof selected from the group consisting of: N-cis-{4-[4-(2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-3,4-dimethoxy-benzenesulfonamide, 3,4-difluoro-N-cis-{4-[4-(2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-benzenesulfonamide, 3,4-difluoro-N-trans-{4-[4-(2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-benzenesulfonamide, 3,4-dimethoxy-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, 3,4-dimethoxy-N-trans-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, N-cis-{4-[4-(2-cyclopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-3,4-dimethoxy-benzenesulfonamide, 5-chloro-N-cis-{4-[4-(2-cyclopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-2-methoxy-benzenesulfonamide, 5-chloro-N-cis-{4-[4-(2-cyclopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-2-fluoro-benzenesulfonamide, 2,3-dihydro-benzo [1,4]dioxine-6-sulfonic acid cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-amide, 5-chloro-2-methoxy-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, 5-chloro-2-methoxy-N-trans-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, 5-chloro-2-fluoro-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, 5-chloro-2-fluoro-N-trans-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, 3-difluoromethoxy-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide, N-cis-(4-{4-[2-(2-fluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-3,4-dimethoxy-benzenesulfonamide, N-trans-(4-{4-[2-(2-fluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-3,4-dimethoxy-benzenesulfonamide, N-cis-(4-{4-[2-(2,2-difluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-3,4-dimethoxy-benzenesulfonamide, N-cis-{4-[4-(4-fluoro-2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-3,4-dimethoxy-benzenesulfonamide, N-cis-{4-[4-(5-fluoro-2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-3,4-dimethoxy-benzenesulfonamide, and N-trans-{4-[4-(5-fluoro-2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexyl}-3,4-dimethoxy-benzenesulfonamide.