Patent ID: 8377462
Filing Date: 2013-02-19
Classification: A61K,A61L

Abstract:
1. A coating for an implantable medical device, comprising: a first layer disposed over a surface of the implantable medical device, comprising poly{[N,N′-sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-co-[N,N′-sebacoyl-L-lysine 4-amino-2,2,6,6-tetramethylpiperidine-N-oxide]}(PEA-TEMPO) and poly {[N,N′-sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-co-[N,N′-sebacoyl-L-lysine benzyl ester]}(PEA-BZ) and a bioactive agent; wherein a second release profile controlling layer disposed over the first layer comprising poly {[N,N′-sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-co-[N,N′-sebacoyl-L-lysine 4-amino-2,2,6,6-tetramethylpiperidine-N-oxide]}(PEA-TEMPO) and poly {[N,N′-sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-co-[N,N′-sebacoyl-L-lysine benzyl ester]}(PEA-BZ) and a bioactive agent; wherein: a topcoat layer disposed over the second layer, wherein the topcoat comprises an biobenefical material selected from the group consisting of poly(propylene oxide), poly (ethylene glycol) acrylate (PEGA), phosphoryl choline, choline, poly(aspirin), poly(styrene-isoprene-styrene)-PEG (SIS-PEG), polystyrene-PEG, polyisobutylene-PEG, polycaprolactone-PEG (PCL-PEG), PLA-PEG, poly(methyl methacrylate)-PEG (PMMA-PEG), polydimethylsiloxane-co-PEG (PDMS-PEG), poly(vinylidene fluoride)-PEG (PVDF-PEG), polypropylene oxide-co-polyethylene glycol, poly(tetramethylene glycol), hydroxy functional poly(vinyl pyrrolidone), fibrinogen, dextran, dextrin, heparin, fragments and derivatives of heparin, glycosamino glycan (GAG), GAG derivatives, elastin, chitosan, alginate, hydroxyethyl methacrylate (HEMA), hydroxypropyl methacrylate (HPMA), hydroxypropylmethacrylamide, methacrylic acid (MA) and acrylic acid (AA).