Patent ID: 6177569
Filing Date: 2001-01-23
Classification: C07D

Abstract:
A compound of the formula ##STR40##or a pharmaceutically acceptable, non-toxic salt thereof, wherein:R.sub.1 and R.sub.2 are independently selected from halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.7 cycloalkyl, or C.sub.3 -C.sub.7 cycloalkoxy, and where either of R.sub.1 and R.sub.2 may be substituted with NR.sub.5 R.sub.6 ;R.sub.5, and R.sub.6 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, or C.sub.3 -C.sub.7 cycloalkyl; orR.sub.5 and R.sub.6 and the nitrogen to which they are attached may be taken together to form a ring having from 5-7 members;R.sub.3 represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, or C.sub.3 -C.sub.7 cycloalkoxy C.sub.1 -C.sub.6 alkyl, where any R.sub.3 with the exception of hydrogen may be substituted with NR.sub.5 R.sub.6 ; andG represents(i) a group of the formula ##STR41##whereR.sub.7, R.sub.7', R.sub.8, R.sub.8', and R.sub.9 are the same or different and are selected from hydrogen, halogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl C.sub.1 -C.sub.6 alkyl, --OR.sub.10, or --NR.sub.11 R.sub.12 ;or R.sub.8 and R.sub.9 taken together with the atoms to which they are attached form a carbocyclic ring or a heterocyclic ring; and R.sub.10 is C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.7 cycloalkyl, andR.sub.11 and R.sub.12 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, or R.sub.11 and R.sub.12 together with the nitrogen to which they are attached form a 3-7 membered ring;(ii) a group of the formula: ##STR42##where X, R.sub.7, R.sub.7', R.sub.8', R.sub.9, and NR.sub.11 R.sub.12 are as defined above;(iii) a group of the formula: ##STR43##where X, R.sub.7, R.sub.7', R.sub.8, R.sub.8', and NR.sub.11 R.sub.2 are as defined above;(iv) a group of the formula: ##STR44##where R.sub.7, R.sub.7', R.sub.8, R.sub.8', and R.sub.9 are as defined above and R.sub.13 and R.sub.14 independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, or R.sub.13 and R.sub.14 taken together with the carbon atom to which they are attached form a C.sub.3 -C.sub.7 cycloalkyl;(v) a group of the formula: ##STR45##where X, R.sub.7', R.sub.8, R.sub.8', R.sub.9, R.sub.13, R.sub.14 and NR.sub.11 R.sub.12 are as defined above;(vi) a group of the formula: ##STR46##where X, R.sub.7, R.sub.7', R.sub.8', R.sub.9, R.sub.13, R.sub.14 and NR.sub.11 R.sub.12 are as defined above;(vii) a group of the formula: ##STR47##where X, R.sub.7, R.sub.7', R.sub.8, R.sub.8', R.sub.13, R.sub.14 and NR.sub.11 R.sub.12 are as defined above;(viii) a group of the formula: ##STR48##where R.sub.7, R.sub.7', R.sub.8', R.sub.9, and NR.sub.5 R.sub.6 are as defined above and Z is C.sub.2 -C.sub.6 alkyl, or Z may be taken together with R.sub.5 or R.sub.6 to form a heterocyclic ring;(ix) a group of the formula: ##STR49##where Z, R.sub.7, R.sub.7', R.sub.8, R.sub.8', and NR.sub.5 R.sub.6 are as defined above;(x) a group of the formula: ##STR50##where Z, R.sub.7',R.sub.8, R.sub.8', R.sub.9, R.sub.13, R.sub.14, and NR.sub.5 R.sub.6 are as defined above;(xi) a group of the formula: ##STR51##where Z, R.sub.7, R.sub.7', R.sub.8', R.sub.9, R.sub.13, R.sub.14, and NR.sub.5 R.sub.6 are as defined above;(xii) a group of the formula: ##STR52##where Z, R.sub.7, R.sub.7', R.sub.8, R.sub.8', R.sub.13, R.sub.14, and NR.sub.5 R.sub.6 are as defined above;(xiii) a group of the formula: ##STR53##where Q represents a heteroaryl group;(xiv) a group of the formula: ##STR54##where R.sub.13, R.sub.14 and Q are as defined above;(xv) a group of the formula: ##STR55##where Z, Q, and NR.sub.5 R.sub.6 are as defined above; or(xvi) a group of the formula: ##STR56##where Z, Q, R.sub.13, R.sub.14, and NR.sub.5 R.sub.6 are as defined above.