Patent ID: 6235738
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR18##wherein:A is a triazine optionally substituted one or more times with .dbd.O or C.sub.1 -C.sub.4 -alkyl;X is oxygen;R.sup.1 is an C.sub.1 -C.sub.4 -alkyl residue substituted with --CONHSO.sub.2 R.sup.8, --CONR.sup.6 R.sup.7, --CH.dbd.NOR.sup.8, --NR.sup.6 R.sup.7, --NHCOR.sup.8, --NHCONR.sup.6 R.sup.7, --NHCOOR.sup.8, --OCONR.sup.6 R.sup.7, --SO.sub.2 NR.sup.6 R.sup.7, or with an N-oxide of formula --NOR.sup.6 R.sup.7 ;R.sup.2 and R.sup.3 which can be the same or different, are hydrogen, --NR.sup.6 R.sup.7, fluorine, chlorine, bromine, nitro, --CF.sub.3, --CN, --OR.sup.8, C.sub.1 -C.sub.4 -alkyl, phenyl, benzyl, or phenyloxy;R.sup.4 and R.sup.5 which can be the same or different, are hydrogen, --NR.sup.6 R.sup.7, fluorine, chlorine, bromine, nitro, --CF.sub.3, --CN, --OR.sup.8, C.sub.1 -C.sub.4 -alkyl, phenyl, benzyl, or phenyloxy;R.sup.6 is hydrogen, C.sub.3 -C.sub.6 -cycloalkyl or C.sub.1 -C.sub.4 -alkyl, each of them being optionally substituted one or more times with hydroxy, phenyl, benzyl, or C.sub.1 -C.sub.4 -alkoxy, orR.sup.6 is phenyl optionally substituted with fluorine, chlorine, bromine, --OR.sup.8, or C.sub.1 -C.sub.4 -alkyl;R.sup.7 is hydrogen, C.sub.3 -C.sub.6 -cycloalkyl or C.sub.1 -C.sub.4 -alkyl, each of them being optionally substituted one or more times with hydroxy, phenyl, benzyl, or C.sub.1 -C.sub.4 -alkoxy, orR.sup.7 is phenyl optionally substituted with fluorine, chlorine, bromine, --OR.sup.8, or C.sub.1 -C.sub.4 -alkyl; or,R.sup.6 and R.sup.7 together with the nitrogen atom form a 5- or 6-membered ring, saturated or unsaturated, which can contain other heteroatoms selected from nitrogen, oxygen and sulfur, wherein the heterocycle can be substituted with C.sub.1 -C.sub.4 -alkyl, phenyl, or benzyl; and,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl, a benzyl or phenyl residue, optionally substituted one or more times with hydroxy, chlorine, bromine, or methoxy, or a pharmaceutically acceptable salt thereof.