Patent ID: 6800652
Filing Date: 2004-10-05
Classification: C07D

Abstract:
A compound of formula (I) or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein;X is S or CH2; L and U, which may be the same or different, are â€”Nâ€”, â€”N+(â€”Oâˆ’)â€” or â€”C(H)â€”; M and Q, which may be the same or different, are â€”Nâ€”, â€”N+(â€”Oâˆ’)â€” or â€”C(R4)â€”; wherein ring A contains 1 or 2 nitrogen atoms, and wherein when L, U, M or Q is â€”N+(â€”Oâˆ’)â€”, ring A contains no other nitrogen atom; R1 and R2, which may be the same or different, are hydrogen, C1-C6alkyl, (CH2)m(C3-C6cycloalkyl) wherein m=0, 1, 2 or 3, or R1 and R2 together with the nitrogen to which they are attached form an azetidine ring; W, Y and Z, which may be the same or different, are hydrogen, halogen, C1-C6alkyl, CF3, OCF3, C1-C4alkylthio or C1-C4alkoxy; or Y and Z are linked so that, together with the interconnecting atoms, Y and Z form a fused 5 to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic, and wherein when Y and Z form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; and wherein W, Y and Z are not all hydrogen; and each R4 is independently: â€”(CH2)pâ€”R5; where p is 0, 1 or 2; R5 is hydrogen, CONR6R7, SO2NR6R7, SO2NHC(&boxH;O)R6, hydroxy, C1-C4alkoxy, NR8SO2R9, NO2, NR6R11, CN, CO2R10, SR10, S(O)R9 or SO2R10; R6, R7, R8 and R10 which may be the same or different, are hydrogen or C1-C6alkyl optionally substituted independently by one or more R12; R9 is C1-C6 alkyl optionally substituted independently by one or more R12; R11 is hydrogen, C1-C6 alkyl optionally substituted independently by one or more R12, C(O)R6, CO2R9, C(O)NHR6 or SO2NR6R7; R12 is fluoro, hydroxy, CO2H, C3-C6cycloalkyl, NH2, CONH2, C1-C6alkoxy, C1-C6alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R13; or R6 and R7, together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R13; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R13; wherein R13 is hydroxy, C1-C4alkoxy, fluoro, C1-C6alkyl, haloalkyl, haloalkoxy, â€”NH2, â€”NH(C1-C6alkyl) or â€”N(C1-C6alkyl)2; or when both M and Q are CR4, the R4 groups are linked so that together with the interconnecting atoms, the R4 groups form a fused 5- to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic.