Patent ID: 8663698
Filing Date: 2014-03-04
Classification: A61J,A61K,A61P,B05D

Abstract:
1. A method for producing a granule of a solid dispersion, comprising steps of: spraying a water-soluble polymer solution in which a poorly water-soluble drug has been dispersed or dissolved, on a mixed powder of an excipient and a disintegrator; and granulating and drying a resultant; wherein a content of the water-soluble polymer is 1 to 10% by weight and a content of the disintegrator is 15 to 50% by weight; the water-soluble polymer is selected from the group consisting of alkylcellulose, hydroxyalkylecellulose, hydroxyalkylakylcellulose, polyvinyl alcohol and polyvinyl pyrrolidone; and the disintegrator is a low-substituted hydroxypropylcellulose having 5 to 16% by weight hydroxylpropoxyl groups.