Patent ID: 7485321
Filing Date: 2009-02-03
Classification: A61K,C07K

Abstract:
1. A purified synthetic polypeptide ligand comprising a 12-mer L-peptide or homologue thereof, said 12-mer L-peptide selected from the group consisting of SEQ ID NO:25 and SEQ ID NOs:38-39 wherein said homologue is at least 9/12 homologous to a 12-mer peptide selected from said group and wherein said 12-mer L-peptide or homologue thereof, when integrated as an N-terminal PIII fusion peptide of an M13 phage confers an ability to bind the phage to either Caco-2 cell, IEC-6 cell, rat, mouse, pig or dog homogenate membrane fractions, said ability being at least as great as that conferred by a similarly integrated 12-mer peptide of SEQ ID NO:67, wherein said ligand comprises a zinc-binding domain.