Patent ID: 6127415
Filing Date: 2000-10-03
Classification: A61K,A61P

Abstract:
A method for treating cancer precancer in a subject in need of such treatment which comprises the induction of apoptosis of cancer cells comprising administering a therapeutically effective amount of an adamantyl retinoid related compound having one of the following generic formulae set forth below or a pharmaceutically acceptable salt, optical and/or geometrical isomer thereof; a compound of generic formula (I): ##STR27## with the proviso that said retinoid of Formula (I) is not an RAR-.gamma. receptor-specific agonist ligand, and whereinW is independently --CH.sub.2 --, --O--, --S--, --SO-- or --SO.sub.2 --,X is a radical selected from among those of the following formulae (i)-(iii): ##STR28## wherein Y is a radical --CO--V--, --CH.dbd.CH--, --CH.sub.3 C.dbd.CH--, --CH.dbd.CCH.sub.3 --, or ##STR29## --CHOH--CH.sub.2 --O--, or ##STR30## V is an oxygen atom (--O--), an aza radical (--NH--), a radical --CH.dbd.CH--or --C.tbd.C--;Z is a radical --CH--and Z' is an oxygen atom, orZ is a nitrogen atom (N) and Z' is an aza radical (--NH--);R.sub.1 is a hydrogen atom, halogen atom, or a lower alkyl radical;R'.sub.1 is a hydrogen atom, halogen atom, or a lower alkyl radical;R.sub.2 is a hydroxyl radical, an alkyl radical, optionally substituted by one or more hydroxyl or acyl groups, an alkoxyl radical, optionally substituted by one or more hydroxyl, alkoxyl or aminocarbonyl groups, and/or optionally interrupted by one or more oxygen atoms, an acyl radical, an aminocarbonyl radical or a halogen;R.sub.3 is a hydrogen atom, a hydroxyl radical, an alkyl radical, or an alkoxyl radical;R.sub.2 and R.sub.3 can form together a radical --O--CH.sub.2 --O--;R.sub.4 is a hydrogen atom, an alkyl radical, an alkoxyl radical, or a halogen;R.sub.5 is a radical --CO--R.sub.10, an alkyl radical, optionally substituted by one or more hydroxyl groups, or a halogen;R.sub.6 is a hydrogen atom, a halogen atom, a hydroxyl group, or an alkoxyl radical;R.sub.7 is a hydrogen atom or a halogen;R.sub.8 is a hydrogen atom, a halogen atom or an alkyl radical;R.sub.9 is a hydrogen atom, a hydroxyl radical or a halogen atom;R.sub.10 is a hydroxyl radical, an alkoxy radical, a radical of formula --Nr'r"", wherein r' and r"" represent a hydrogen atom, an optionally substituted aminoalkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid or sugar residue;or a compound having generic formula (III): ##STR31## wherein R'.sub.1, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and W are as defined for compounds of formula (I) or is a compound of formula (IV) ##STR32## wherein R'.sub.1, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and W are as defined above for compounds of formula (I).