Patent ID: 7538190
Filing Date: 2009-05-26
Classification: C07B,C07K

Abstract:
1. A method for the synthesis of a peptide with two intramolecular dicarba bridges, the method comprising: (a) providing a first peptide comprising a series of amino acids attached to a solid support, wherein two amino acids comprise sidechains with a first pair of complementary metathesisable groups and two amino acids comprise sidechains with a second pair of blocked complementary metathesisable groups; (b) subjecting the peptide to cross-metathesis to form a peptide with an unsaturated dicarba bridge between the amino acids bearing the first pair of complementary metathesisable groups; (c) unblocking the second pair of complementary metathesisable groups; and (d) subjecting the peptide to cross-metathesis to form a peptide with an unsaturated dicarba bridge between the amino acids bearing the second pair of complementary metathesisable groups, to form a dicarba bridge between the amino acids that bore the second metathesisable groups.