Patent ID: 6485743
Filing Date: 2002-11-26
Classification: A61K,A61P

Abstract:
An oral preparation of itraconazole having improved bioavailability, which is prepared by dissolving 1.0 to 2.5 wt parts of at least one pH-dependent inert hydrophilic polymer selected from the group consisting of polyvinylacetal dithylarmoacetate and aminoalkyl methacrylate copolymer with 1.0 wt part of itraconazole in at least one solvent selected from the group consisting of methylenechloride, chloroform ethanol and methanol, and subjecting the resulting solution obtained after the dissolution to a dispersing and spray-drying process, to prepare particles of a solid dispersion consisting of itraconazole and said hydrophilic polymer for the manufacture of an oral preparation.