Patent ID: 7803365
Filing Date: 2010-09-28
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for treating a vascular disease in a mammal, said method comprising the steps of: administering intravenously an effective amount of a gutless adenoviral vector comprising a polynucleotide encoding a functional thrombomodulin protein having the amino acid sequence of SEQ ID NO: 2 and a regulatory element operably linked to said polynucleotide, wherein said gutless adenoviral vector comprises the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses said functional thrombomodulin protein in said mammal, and wherein said vascular disease is selected from the group consisting of atherosclerotic cardiovascular disease, myocardial infraction, fibrinolysis in hemophilic plasma, and end stage renal failure.