Patent ID: 7812146
Filing Date: 2010-10-12
Classification: A61P,C07K

Abstract:
1. A hybrid Hepatocyte Growth Factor (HGF) construct comprising: (a) a first cDNA which has the same sequence as exons 1-4 of the human HGF gene wherein said exons 1-4 are arranged in sequential order without an intron therebetween, or degenerates thereof which do not alter the amino acid sequence encoded by said first cDNA, (b) a polynucleotide that has the same sequence as intron 4 of a HGF gene or a functional fragment thereof, and (c) a second cDNA which has the same sequence as exons 5-18 of the human HGF gene wherein said exons 5-18 are arranged in sequential order without an intron therebetween, or degenerates thereof which do not alter the amino acid sequence encoded by said second cDNA; wherein (b) is located between (a) and (c); and the HGF construct simultaneously encodes two heterotypes of human HGF.