Patent ID: 6066739
Filing Date: 2000-05-23
Classification: A61P,C07D

Abstract:
A method for producing an optically active 4-[.alpha.-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid of the formula (II) ##STR20## wherein carbon atom marked with * shows (S)- or (R)-, or a pharmaceutically acceptable salt thereof, which comprises subjecting a compound of the formula (I) ##STR21## wherein R.sup.1 is a lower alkyl, a phenylalkyl or a substituted phenylalkyl;R.sup.2 is a lower alkyl, a phenylalkyl or a substituted phenylalkyl;Ar is a phenyl, a substituted phenyl, a naphthyl, a substituted naphthyl, a thienyl, a substituted thienyl, a furyl, a substituted furyl, a pyridyl or a substituted pyridyl;A is a single bond or --NHSO.sub.2 --; andthe carbon atom marked with * shows (S)- or (R)-,to optical resolution by fractional crystallization to give an optically active compound thereof and subjecting the obtained optically active compound to hydrolysis reaction.