Patent ID: 7820818
Filing Date: 2010-10-26
Classification: A61P,C07D

Abstract:
1. A compound of formula I, or a pharmaceutically acceptable salt thereof In which R is H, —R2, —OR2 or NR1R2, wherein R1 is H, lower alkyl or C R2 is lower alkyl or C wherein R1 and R2 are independently, optionally substituted by halo, hydroxy, lower alkoxy, CN, NO X is ═C(Z)—, wherein Z is —C≡C—CH wherein P and Q independently are H, lower alkyl or aryl, R3 is aryl, aryl-lower alkyl, C wherein R3 is independently, optionally substituted by 1-3 groups, selected from halo, hydroxy, oxo, lower alkoxy, CN or NO R5 is aryl-lower alkyl, or N-heterocyclyl as defined above, and wherein R5 is optionally substituted by R7 which represents from 1 to 5 substitutents selected from halo, hydroxy, CN, NO wherein N-heterocyclyl denotes a saturated, partially unsaturated or aromatic nitrogen containing heterocyclic moiety attached via a nitrogen atom thereof having from 3 to 8 ring atoms optionally containing a further 1, 2 or 3 heteroatoms selected from N, NR6, O, S, S(O) or S(O) wherein the N-heterocyclyl is optionally linked in a spiro structure with a 3 to 8 membered cycloalkyl or heterocyclic ring wherein the heterocyclic ring has from 3 to 10 ring members and contains from 1 to 3 heteroatoms selected from N, NR6, O, S, S(O) or S(O) wherein heterocyclyl denotes a ring having from 3 to 10 ring members and containing from 1 to 3 heteroatoms selected from N, NR6, O, S, S(O) or S(O) wherein R7 is optionally substituted by from 1 to 3 substitutents selected from halo, hydroxy, optionally mono- or di-lower-alkyl substituted amino, lower-alkyl carbonyl, lower-alkoxy or lower-alkylamido; Y is —NR8R9, wherein R8 is H, or optionally substituted (lower alkyl, aryl, aryl-lower alkyl, C wherein R8 is optionally substituted by R10 which represents from 1 to 4 substitutents selected from halo, hydroxy, CN, NO wherein R10 is optionally substituted by R11 which represents from 1 to 4 substituents selected from halo, hydroxy, CN, NO wherein R11 is optionally substituted by R12 which represents from 1 to 4 substituents selected from halo, hydroxy, CN, NO wherein R9 is independently H, or optionally substituted (lower alkyl, aryl, aryl-lower alkyl, C wherein R9 is optionally substituted by halo, hydroxy, oxo, lower alkoxy, CN, NO