Patent ID: 6852508
Filing Date: 2005-02-08
Classification: A61K,C07K

Abstract:
1. A composition comprising an isolated polynucleotide encoding an amino-terminal-modified chemokine, wherein the amino-terminal-modified chemokine comprises at least one methionine, at least one aminooxypentane residue, or at least one GroHEK peptide covalently attached to the amino terminus of the chemokine, and wherein the polynucleotide is selected from the group consisting of: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:6; (b) a polynucleotide comprising the nucleotide sequence of the protein-coding sequence of the polynucleotide encoding met-hDSF-1α deposited under accession number ATCC 98506; (c) a polynucleotide encoding an amino-terminal-modified chemokine comprising the amino acid sequence of SEQ ID NO:10; (d) a polynucleotide encoding a protein comprising an amino-terminal fragment of the amino acid sequence of SEQ ID NO: 10; (e) a polynucleotide comprising a nucleotide sequence complementary to any one of the polynucleotides specified in (a)-(d) above; and (f) a polynucleotide capable of hybridizing at either (i) 4×SSC at 65° C. or (ii) 50% formamide and 4×SSC at 42° C., to any one of the polynucleotides specified in (a)-(e) above.