Patent ID: 7863334
Filing Date: 2011-01-04
Classification: A61P,C07C,C07D

Abstract:
1. A compound, having the formula: or a salt thereof; wherein X wherein Z is -(A wherein a is 1; wherein b is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9; wherein x is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9; wherein y is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9; wherein m is 1; wherein A wherein Q is a substituted of unsubstituted group having the following formula: and wherein when substituted, said Q is substituted with one or more substituent groups selected from the group consisting of hydroxy, halo, bromo, chloro, iodo, fluoro, —N 3 , —CN, —NC, —SH, —NO 2 , NH 2 , (C 1 -C 20 )alkyl, phenyl, (C 3 -C 20 )cycloalkyl, (C 1 -C 20 )alkoxy, (C 3 -C 25 )heteroaryl, (C 3 -C 25 )heterocyclic, (C 2 -C 20 )alkenyl, (C 3 -C 20 ) cycloalkenyl, (C 2 -C 20 )alkynyl, (C 5 -C 20 )cycloalkynyl, (C 5 -C 25 )aryl, perhalo(C 1 -C 20 )alkyl, (C 1 -C 20 )alkyl-O—, phenyl-O—, (C 3 -C 20 )cycloalkyl-O—, (C 3 -C 25 )heteroaryl-O—, (C 3 -C 25 )heterocyclic-O—, (C 2 -C 20 )alkenyl-O—, (C 3 -C 20 ) cycloalkenyl-O—, (C 2 -C 20 )alkynyl-O—, (C 5 -C 20 )cycloalkynyl-O—, (C 5 -C 25 )aryl-O—, perhalo(C 1 -C 20 )alkyl-O—, (C 1 -C 20 )alkyl-S—, phenyl-S—, (C 3 -C 20 )cycloalkyl-S—, (C 3 -C 25 )heteroaryl-S—, (C 3 -C 25 )heterocyclic-S—, (C 2 -C 20 )alkenyl-S—, (C 3 -C 20 )cycloalkenyl-S—, (C 2 -C 20 )alkynyl-S—, (C 5 -C 20 )cycloalkynyl-S—, (C 5 -C 25 )aryl-S—, perhalo(C 1 -C 20 )alkyl-S—, (C 1 -C 20 )alkyl-SO 2 —, phenyl-SO 2 —, (C 3 -C 20 )cycloalkyl-SO 2 —, (C 1 -C 20 )alkoxy-SO 2 —, (C 3 -C 25 )heteroaryl-SO 2 —, (C 3 -C 25 )heterocyclic-SO 2 —, (C 2 -C 20 )alkenyl-SO 2 —, (C 3 -C 20 )cycloalkenyl-SO 2 —, (C 2 -C 20 )alkynyl-SO 2 —, (C 5 -C 20 )cycloalkynyl-SO 2 —, (C 5 -C 25 )aryl-SO 2 —, perhalo(C 1 -C 20 )alkyl-SO 2 —, H 2 N—SO 2 —, (C 1 -C 20 )alkyl-NH—SO 2 —, phenyl-NH—SO 2 —, (C 3 -C 20 )cycloalkyl-NH—SO 2 —, (C 1 -C 20 )alkoxy-NH—SO 2 —, (C 3 -C 25 )heteroaryl-NH—SO 2 —, (C 3 -C 25 )heterocyclic-NH—SO 2 —, (C 2 -C 20 )alkenyl-NH—SO 2 —, (C 3 -C 20 )cycloalkenyl-NH—SO—, (C 2 -C 20 )alkynyl-NH—SO 2 —, (C 5 -C 20 )cycloalkynyl-NH—SO 2 —, (C 5 -C 25 )aryl-NH—SO 2 —, perhalo(C 1 -C 20 )alkyl-NH—SO 2 —, {(C 1 -C 20 )alkyl} 2 N—SO 2 —, {phenyl} 2 N—SO 2 —, {(C 3 -C 20 )cycloalkyl} 2 N—SO 2 , {(C 1 -C 20 )alkoxy} 2 N—SO 2 —, {(C 3 -C 25 )heteroaryl} 2 N—SO 2 —, {(C 3 -C 25 )heterocyclic} 2 N—SO 2 —, {(C 2 -C 20 )alkenyl} 2 N—SO 2 —, {(C 2 -C 20 )alkynyl} 2 N—SO 2 —, {(C 5 -C 20 )cycloalkynyl} 2 N—SO 2 —, {(C 5 -C 25 )aryl} 2 N—SO 2 —, {perhalo(C 1 -C 20 )alkyl} 2 N—SO 2 —, (C 1 -C 20 )alkyl-SO 2 —NH—, phenyl-SO 2 —NH—, (C 3 -C 20 )cycloalkyl-SO 2 —NH—, (C 1 -C 20 )alkoxy-SO 2 —NH—, (C 3 -C 25 )heteroaryl-SO 2 —NH—, (C 3 -C 25 )heterocyclic-SO 2 —NH—, (C 2 -C 20 )alkenyl-SO 2 —NH—, (C 3 -C 20 ) cycloalkenyl-SO 2 —NH—, (C 2 -C 20 )alkynyl-SO 2 —NH—, (C 5 -C 20 )cycloalkynyl-SO 2 —NH—, (C 5 -C 25 )aryl-SO 2 —NH—, perhalo(C 1 -C 20 )alkyl-SO 2 —NH—, (C 1 -C 20 )alkyl-NH—, phenyl-NH—, (C 3 -C 20 )cycloalkyl-NH—, (C 1 -C 20 )alkoxy-NH—, (C 3 -C 25 )heteroaryl-NH—, (C 3 -C 25 )heterocyclic-NH—, (C 2 -C 20 )alkenyl-NH—, (C 3 -C 20 )cycloalkenyl-NH—, (C 2 -C 20 )alkynyl-NH—, (C 5 -C 20 )cycloalkynyl-NH—, (C 5 -C 25 )aryl-NH—, perhalo(C 1 -C 20 )alkyl-NH—, {(C-C 20 )alkyl} 2 N—, {phenyl} 2 N—, {(C 3 -C 20 )cycloalkyl} 2 N—, {(C 1 -C 20 )alkoxy} 2 N—, {(C 3 -C 25 )heteroaryl } 2 N—, {(C 3 -C 25 )heterocyclic} 2 N—, {(C 2 -C 20 )alkenyl} 2 N—, {(C 3 -C 20 )cycloalkenyl} 2 N—, {(C 2 -C 20 )alkynyl} 2 N—, {(C 5 -C 20 )cycloalkynyl} 2 N—, {(C 5 -C 25 )aryl} 2 N—, {perhalo(C 1 -C 20 )alkyl} 2 N—, (C 1 -C 20 )alkyl-(C═O)—NH—, phenyl-(C═O)—NH—, (C 3 -C 20 )cycloalkyl-(C═O)—NH—, (C 1 -C 20 )alkoxy-(C═O)—NH—, (C 3 -C 25 )heteroaryl-(C═O)—NH—, (C 3 -C 25 )heterocyclic-(C═O)—NH—, (C 2 -C 20 )alkenyl-(C═O)—NH—, (C 3 -C 20 )cycloalkenyl-(C═O)—NH—, (C 2 -C 20 )alkynyl-(C═O)—NH—, (C 5 -C 20 )cycloalkynyl-(C═O)—NH—, (C 5 -C 25 )aryl-(C═O)—NH—, perhalo(C 1 -C 20 )alkyl-(C═O)—NH—, (C 1 -C 20 )alkyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, phenyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 3 -C 20 )cycloalkyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 1 -C 20 )alkoxy-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 3 -C 25 )heteroaryl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 3 -C 25 )heterocyclic-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 2 -C 20 )alkenyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 3 -C 20 )cycloalkenyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 2 -C 20 )alkynyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 5 -C 20 )cycloalkynyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, (C 5 -C 25 )aryl-(C═O)—{((C 1 -C 20 )alkyl)N}—, perhalo(C 1 -C 20 )alkyl-(C═O)—{((C 1 -C 20 )alkyl)N}—, phenyl-(C═O)—NH—, phenyl-(C═O)-{(phenyl)N}—, (C 1 -C 20 )alkyl-(C═O)-{(phenyl)N}—, (C 3 -C 20 )cycloalkyl-(C═O)-{(phenyl)N}—, (C 1 -C 20 )alkoxy-(C═O)-{(phenyl)N}—, (C 3 -C 25 )heteroaryl-(C═O)-{(phenyl)N}—, (C 3 -C 25 )heterocyclic-(C═O)-{(phenyl)N}—, (C 2 -C 20 )alkenyl-(C═O)-{(phenyl)N}—, (C 3 -C 20 )cycloalkenyl-(C═O)-{(phenyl)N}—, (C 2 -C 20 )alkynyl-(C═O)-{(phenyl)N}—, (C 5 -C 20 )cycloalkynyl-(C═O)-{(pheny)N}—, (C 5 -C 25 )aryl-(C═O)-{(phenyl)N}—, perhalo(C 1 -C 20 )alkyl-(C═O)-{(phenyl)N}—, H 2 N(C═O)—, (C 1 -C 20 )alkyl-NH—(C═O)—, phenyl-NH—(C═O)—, (C 3 -C 20 )cycloalkyl-NH—(C═O)—, (C 1 -C 20 )alkoxy-NH—(C═O)—, (C 3 -C 25 )heteroaryl-NH—(C═O)—, (C 3 -C 25 )heterocyclic-NH—(C═O)—, (C 2 -C 20 )alkenyl-NH—(C═O)—, (C 3 -C 20 )cycloalkenyl-NH—(C═O)—, (C 2 -C 20 )alkynyl-NH—(C═O)—, (C 5 -C 20 )cycloalkynyl-NH—(C═O)—, (C 5 -C 25 )aryl-NH—(C═O)—, perhalo(C 1 -C 20 )alkyl-NH—(C═O)—, {(C 1 -C 20 )alkyl} 2 N—(C═O)—, {phenyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 3 -C 20 )cycloalkyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 1 -C 20 )alkoxy} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 3 -C 25 )heteroaryl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 3 -C 25 )heterocyclic} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 2 -C 20 )alkenyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 3 -C 20 )cycloalkenyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 2 -C 20 )alkynyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 5 -C 20 )cycloalkynyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {(C 5 -C 25 )aryl} {(C 1 -C 20 )alkyl}N—(C═O)—, {perhalo(C 1 -C 20 )alkyl} {(C 1 -C 20 )alkyl}N—(C═O)—, {phenyl} 2 N-(C═O)—, {(C 3 -C 20 )cycloalkyl} {phenyl}N—(C═O)—, {(C 1 -C 20 )alkoxy} {phenyl}N—(C═O)—, {(C 3 -C 25 )heteroaryl} {phenyl}N—(C═O)—, {(C 3 -C 25 )heterocyclic} {phenyl}N—(C═O)—, {(C 2 -C 20 )alkenyl} {phenyl}N—(C═O)—, {(C 3 -C 20 )cycloalkenyl} {phenyl}N—(C═O)—, {(C 2 -C 20 )alkynyl} {phenyl }N—(C═O)—, {(C 5 -C 20 )cycloalkynyl} {phenyl}N—(C═O)—, {(C 5 -C 25 )aryl} {phenyl}N—(C═O)—, {perhalo(C 1 -C 20 )alkyl} {phenyl}N—(C═O)—, HO—(C═O)—, (C 1 -C 20 )alkyl-(C═O)—, (C 3 -C 25 )heteroaryl-(C═O)—, (C 3 -C 25 )heterocyclic-(C═O)—, (C 2 -C 20 )alkenyl-(C═O)—, (C 3 -C 20 ) cycloalkenyl-(C═O)—, (C 2 -C 20 )alkynyl-(C═O)—, (C 5 -C 25 )aryl-(C═O)—, perhalo(C 1 -C 20 )alkyl-(C═O)—, phenyl-(C═O)—, (C 1 -C 20 )alkyl-O—(C═O)—, (C 3 -C 25 )heteroaryl-O—(C═O)—, (C 3 -C 25 )heterocyclic-O—(C═O)—, (C 2 -C 20 )alkenyl-O—(C═O)—, (C 3 -C 20 ) cycloalkenyl-O—(C═O)—, (C 2 -C 20 )alkynyl-O—(C═O)—, (C 5 -C 25 )aryl-O—(C═O)—, perhalo(C 1 -C 20 )alkyl-O—(C═O)—, phenyl-O—(C═O)—, (C 1 -C 20 )alkyl-(C═O)—O—, (C 3 -C 25 )heteroaryl-(C═O)—O—, (C 3 -C 25 )heterocyclic-(C═O)—O—, (C 2 -C 20 )alkenyl-(C═O)—O—, (C 3 -C 20 )cycloalkenyl-(C═O)—O—, (C 2 -C 20 )alkynyl-(C═O)—O—, (C 5 -C 25 )aryl-(C═O)—O—, phenyl-(C═O)—O—, perhalo(C 1 -C 20 )alkyl-(C═O)—O—, and salts thereof; wherein each of the aforesaid (C wherein R wherein each of the aforesaid (C and wherein two independently chosen R