Patent ID: 6446010
Filing Date: 2002-09-03
Classification: C07K,G01N,G16B

Abstract:
A method of generating a frequency distribution of scores for a particular experimental condition, wherein the scores relate to random identifications of biological molecules, the method comprising:a) generating mass data for the particular experimental condition for biological molecules in a biological molecule database, wherein each biological molecule comprises a set of constituent parts; b) generating mass data of a hypothetical biological molecule for the experimental condition, wherein the hypothetical biological molecule comprises a set of constituent parts, and wherein the set of constituent parts of the hypothetical biological molecule is different from every set of constituent parts of each biological molecule of the database; c) comparing the data generated in step (b) with the data generated for each biological molecule in step (a); d) calculating a score for each comparison in step (c), wherein the score is a function of similarity between the data generated in step (a), which corresponds to a particular database biological molecule, and the data generated in step (b); e) selecting a score from the top twenty scores calculated in step (d), wherein the top twenty scores denote a high degree of similarity; f) repeating steps (b) through (e) with different hypothetical biological molecules until a sufficient quantity of scores are selected; and g) determining the frequency of selecting each score and generating therefrom a frequency distribution of scores.