Patent ID: 8354234
Filing Date: 2013-01-15
Classification: B82Y,G01N

Abstract:
1. A method of assaying a target analyte in a sample comprising the steps of: a) providing a composition comprising antibody-conjugated magnetic nanoparticles (Ab-mNPs), wherein each of the Ab-mNPs comprises: iii) antibody molecules specific for a target analyte, covalently conjugated to the cross-linkers; and b) exposing a sample that may contain the target analyte to the Ab-mNPs to allow the target analyte to be captured by the Ab-mNPs; c) subjecting the Ab-mNPs and the sample from step (b) to a magnetic field to separate the Ab-mNPs and the captured target analyte from the rest of the sample; and d) performing mass spectrometry on the Ab-mNPs and the captured target analyte from step (c) to obtain a mass spectrum for assaying the target analyte;