Patent ID: 6440944
Filing Date: 2002-08-27
Classification: A61K,A61P,C07K

Abstract:
A method of administering a therapeutic gene product to a particular skeletal muscle of a mammal, which method comprises: (a) inducing in the mammal systemic neutralizing antibodies to a replication-incompetent adenoviral gene transfer vector by systemically or intramuscularly administering an antigen that will induce systemic neutralizing antibodies to the replication-incompetent adenoviral gene transfer vector, and (b) intramuscularly administering the replication-incompetent adenoviral gene transfer vector comprising a therapeutic gene encoding a therapeutic gene product to the particular skeletal muscle of the mammal such that the therapeutic gene is expressed and the therapeutic gene product is produced in the particular skeletal muscle of the mammal, whereby the therapeutic gene product is administered to the particular skeletal muscle of the mammal to produce a therapeutic benefit in the mammal and the replication-incompetent adenoviral gene transfer vector is neutralized outside of the particular skeletal muscle of the mammal, wherein, when the systemic neutralizing antibodies are induced in (a) by intramuscular administration of an antigen that will induce systemic neutralizing antibodies to the replication-incompetent adenoviral gene transfer vector, the antigen is the same as the adenoviral gene transfer vector, except that it does not contain the therapeutic gene encoding the therapeutic gene product.