Patent ID: 6946465
Filing Date: 2005-09-20
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A poly-substituted pteridinedione (lumazine), being selected from the group consisting of: 1,3-dimethyl-6-[(E)-2-(pyrid-3-yl)vinyl]lumazine, 1,3-dimethyl-6-[(E)-2-(pyrid-4-yl)vinyl]lumazine, 6-(1,2-dibromo-2-phenylethyl)-1,3-dimethyllumazine, 1,3-dimethyl-6-[(E)-4-(phenyl)butadienyl]lumazine, 6-(1,2-dibromo-2-(methoxycarbonyl)ethyl)-1,3-dimethyllumazine, 6-(2-bromo-2-methoxycarbonyl-ethenyl)-1,3-dimethyllumazine, 6-[(2-acetyl-2-ethoxycarbonyl)acetyl]-1,3-dimethyllumazine, 6-[2,2-(diethoxycarbonyl)acetyl]-1,3-dimethyllumazine, 6-(1-methoxy-2-methoxycarbonyl)ethenyl)-1,3-dimethyllumazine, 1,3-dimethyl-6-[(2-nitro)ethenyl]lumazine, 6-[(1-hydroxy-2-nitro)ethyl]-1,3-dimethyllumazine, 6-[(1-ethylthio-2-nitro)ethyl]-1,3-dimethyllumazine, 1,3-dimethyl-7-[(E)-2-(pyrid-2-yl)vinyl]lumazine, 1,3-dimethyl-7-[(E)-2-(pyrid-3-yl)vinyl]lumazine, 1,3-dimethyl-7-[(E)-2-(pyrid-4-yl)vinyl]lumazine, 1,3-dimethyl-7-[(E)-4-(phenyl)butadienyl]lumazine, 7-1,2-dibromo-2-(methoxycarbonyl)ethyl)-1,3-dimethyllumazine, 7-[(E)-2-methoxycarbonylethenyl]lumazine, 7-(1,2-dibromo-2-phenylethyl)-1,3-dimethyllumazine, 7-(1-bromo-2-phenyl)ethenyl-1,3-dimethyllumazine, 1,3-dimethyl-7-(E)-styryllumazine, 1,3-dimethyl-6-phenyl-7-mercaptolumazine, 7-methoxy-1,3-dimethyl-6-phenyllumazine, 7-chioro-1,3-dimethyl-6-phenylluniazine, 6-benzoyl-7,8-dihydro-1,3-dimethyl-7-(4-methoxyphenyl)lumazine, 6-benzoyl-1,3-dimethyl-7-(4-methoxyphenyl)lumazine, 6-benzoyl-7,8-dihydro-1,3-dimethyl-7-phenyllumazine, 6-benzoyl-1,3-dimethyl-7-phenyllumazine, 7-methoxy-1,3-dimethyl-6-styryllumazine, 7-hydroxy-1,6-diphenyllumazine, 7-hydroxy-6-phenyl-1,3-di-n-propyllumazine, 6-formyl-7-hydroxy-1,3-dimethyl-lumazine, 6-hydroxy-7-formyl-1,3-dimethyl-lumazine, 6-cyano-7-chloro-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-chloro-1,3-dimethyl-lumazine, 6-(1,3-dioxolanyl)-7-chloro-1,3-dimethyl-lumazine, 6-dichloromethyl-7-chloro-1,3-dimethyl-lumazine, 6-chloro-7-cyano-1,3-dimethyl-lumazine, 6-cyano-7-isobutylamino-1,3-dimethyl-lumazine, 6-cyano-7-benzylamino-1,3-dimethyl-lumazine, 6-cyano-7-acetenylamino-1,3-dimethyl-lumazine, 6-cyano-7-cyclohexylamino-1,3-dimethyl-lumazine, 6-cyano-7-dibutylamino-1,3-dimethyl-lumazine, 6-cyano-7-imidazolyl-1,3-dimethyl-lumazine, 6-cyano-7-mercaptoisopropyl-1,3-dimethyl-lumazine, 6-cyano-7-mercaptobenzyl-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-n-butylamino-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-neopentylamino-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-(2-propenylamino)-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-piperidinyl-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-phenylhydrazino-1,3-dimethyl-lumazine, 6-ethylcarboxylate-7-mercaptoethyl-1,3-dimethyl-lumazine, 6-formyl-7-isopropylamino-1,3-dimethyl-lumazine, 6-formyl-7-hydroxyethylamino-1,3-dimethyl-lumazine, 6-formyl-7-(1-azacycloheptyl)-1,3-dimethyl-lumazine, 6-formyl-7-thiomorpholino-1,3-dimethyl-lumazine, 6-formyl-7-cyclopropylamino-1,3-dimethyl-lumazine, 6-dichloromethyl-7-mercaptobenzyl-1,3-dimethyl-lumazine, 6-dichloromethyl-7-ethylmercaptoacetate-1,3-dimethyl-lumazine, 6-benzylamino-1,3,7-trimethyl-lumazine, 6-pyrrolidinyl-1,3,7-trimethyl-lumazine, 6-chloro-7-piperidyl-1,3-diimethyl-lumazine, 7-(2-phenylethenyl)-1,3,6-trimethyl-lumazine, 6-[2-(p-trifluoromethylphenyl)ethenyl]-1,3-dimethyllumazine, 6-[2-(p-trifluoromethylphenyl)ethenyl]-1,3-dimethyllumazine, 6-[2-phenylethenyl]-1,3-dimethyllumazine, 6-[2-(p-trifluoromethoxyphenyl)ethenyl]-1,3-dimethyllumazine, 6-cyano-7-ethylmercaptoacetate-1,3-dimethyllumazine, 3-methyl-6-phenyl-7-chloro-lumazine, 1-methyl-6-phenyl-7-hydroxy-lumazine, 1-methyl-6-(4′-methoxyphenyl)-7-hydroxy-lumazine, 1-methyl-6-(4′-methylphenyl)-7-hydroxy-lumazine, 1,6-diphenyl-7-hydroxy-lumazine, 1-benzyl-6-phenyl-7-hydroxy-lumazine, 1-methyl-6-(3′,4′-dimethoxyphenyl)-7-hydroxy-lumazine, 1-methyl-6-(4′-chlorophenyl)-7-hydroxy-lumazine, 1-methyl-6-phenyl-7-chloro-lumazine, 1-methyl-6-(4′-methoxyphenyl)-7-chloro-lumazine, 1-methyl-6-(4′-methylphenyl)-7-chloro-lumazine, 1,6-diphenyl-7-chloro-lumazine, 1-benzyl-6-phenyl-7-chloro-lumazine, 1-methyl-6-(3′,4′-dimethoxyphenyl)-7-chloro-lumazine, 1-methyl-6-(4′-chlorophenyl)-7-chloro-lumazine, 1,3-dimethyl-6-phenyl-7-phenoxylumazine, 1,3-dimethyl-6-phenyl-7-piperidinolumazine, 1,3-dimethyl-6-phenyl-7-morpholinolumazine, 1,3-dimethyl-6-phenyl-7-( 4′-N-acetyl)piperazinolumazine, and 1,3-dimethyl-6-phenyl-7-isopropylaminolumazine.