Patent ID: 6855698
Filing Date: 2005-02-15
Classification: A61P,C07H

Abstract:
1. A compound of formula I having a topoisomerase I selectivity index of greater than about 100; its enantiomers, diastereomers, pharmaceutically acceptable salts, hydrates, prodrugs and solvates thereof; wherein R a and R b are independently selected from the group consisting of H and O, provided that when O is selected R a and R b are taken together to form O; R a ′ and R b ′ are independently selected from the group consisting of H and O, provided that when O is selected R a ′ and R b ′ are taken together to form O; X 1 , X 1 ′, X 2 and X 2 ′ are each independently selected from the group consisting of F, Br and H; Q is selected from the group consisting of NH, S and O; and R is a substituted hexose group, wherein said hexose group is substituted with one of: (a) a fluoro (F) or an azido (N (b) a hydroxyl (OH) at the 3-position and one of an alkyl, a carboxylic acid, an alkylamino, an alkylmorpholino, an alkylthiol, an alkoxy, an alkylnitro and a nitro at the 4-position.