Patent ID: 6251636
Filing Date: 2001-06-26
Classification: C12N,C12P

Abstract:
An isolated recombinant DNA compound that comprises a coding sequence for a domain of a) a loading module or b) any one of extender modules one through four, which domain is of an oleandolide polyketide synthase (PKS) other than the acyl carrier protein domain of extender module four, wherein said extender modules are numbered as shown in FIG. 2, which domain is encoded by a coding sequence selected from the group consisting of nucleotides 5799-7055 of SEQ ID NO:1, nucleotides 7458-8563 of SEQ ID NO:1, nucleotides 8634-48873 of SEQ ID NO:1, nucleotides 8955-10205 of SEQ ID NO:1, nucleotides 10512-11549 of SEQ ID NO:1, nucleotides 12258-12818 of SEQ ID NO:1, nucleotides 13092-13349 of SEQ ED NO:1, nucleotides 13407-14690 of SEQ ID NO:1, nucleotides 14997-16031 of SEQ ID NO:1, nucleotides 16872-17423 of SEQ ID NO:1, nucleotides 17709-17996 of SEQ ID NO:1, nucleotides 18357-19643 of SEQ ID NO:1, nucleotides 19965-20999 of SEQ ID NO:1, nucleotides 21897-22449 of SEQ ID NO:1, nucleotides 22728-22985 of SEQ ID NO:1, nucleotides 23046-24329 of SEQ ID NO:1, nucleotides 24645-25682 of SEQ ID NO:1, nucleotides 25719-26256 of SEQ ID NO:1, nucleotides 27429-28301 of SEQ ID NO:1, and nucleotides 28314-28862 of SEQ ID NO:1, or a sequence that encodes an amino acid sequence identical to that encoded by any of the foregoing sequences.