Patent ID: 6716606
Filing Date: 2004-04-06
Classification: A61K,C07K,C25D

Abstract:
A process for the production of a polypeptide product having part or all of the primary structural conformation and the hematopoietic biological activity of naturally occurring pluripotent granulocyte colony-stimulating factor, said process comprising:growing, under suitable nutrient conditions, host cells transformed or transfected with a DNA molecule in a manner allowing expression of said polypeptide product, wherein said DNA molecule encodes a polypeptide product selected from the group consisting of: [Met-âˆ’1]hpG-CSF; [Ser17]hpG-CSF; [Ser36]hpG-CSF; [Ser42]hpG-CSF; [Ser64]hpG-CSF; [Ser74]hpG-CSF; [Metâˆ’1, Ser17]hpG-CSF; [Metâˆ’1, Ser36]hpG-CSF; [Metâˆ’1, Ser42]hpG-CSF; [Metâˆ’1, Ser64]hpG-CSF; and [Metâˆ’1, Ser74]hpG-CSF.