Patent ID: 6143895
Filing Date: 2000-11-07
Classification: C07D,G01N

Abstract:
A tetrahydro-quinoline compound of the formula: ##STR6## wherein: R.sup.1 is selected from the group consisting of C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 substituted alkyl, C.sub.2 to C.sub.7 alkenyl, C.sub.2 to C.sub.7 substituted alkenyl, C.sub.2 to C.sub.7 alkynyl, C.sub.2 to C.sub.7 substituted alkynyl, C.sub.3 to C.sub.7 cycloalkyl, C.sub.3 to C.sub.7 substituted cycloalkyl, C.sub.5 to C.sub.7 cycloalkenyl, C.sub.5 to C.sub.7 substituted cycloalkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C.sub.7 to C.sub.12 phenylalkyl, C.sub.7 to C.sub.12 substituted phenylalkyl or a group of the formula:--(CH.sub.2).sub.n --Ar--(CH.sub.2).sub.m --wherein n and m are independently selected from a number 0 to 6; and Ar is an aryl group selected from the group consisting of phenyl, substituted phenyl, heteroaryl and substituted heteroaryl;R.sup.2 is selected from the group consisting of hydroxy, C.sub.1 to C.sub.7 alkoxy, C.sub.1 to C.sub.7 substituted alkoxy, C.sub.1 to C.sub.7 acyloxy, C.sub.7 to C.sub.12 phenylalkoxy, C.sub.7 to C.sub.12 substituted phenylalkoxy, phenoxy, substituted phenoxy, phthalimide, substituted phthalimide, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, C.sub.1 to C.sub.4 alkylthio, C.sub.1 to C.sub.4 substituted alkylthio, C.sub.1 to C.sub.4 alkylsulfonyl, C.sub.1 to C.sub.4 substituted alkylsulfonyl, C.sub.1 to C.sub.4 alkylsulfoxide, C.sub.1 to C.sub.4 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl and substituted phenylsulfonyl;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently, selected from the group consisting of a hydrogen atom, halo, hydroxy, protected hydroxy, cyano, nitro, C.sub.1 to C.sub.6 alkyl, C.sub.2 to C.sub.7 alkenyl, C.sub.2 to C.sub.7 alkynyl, C.sub.1 to C.sub.6 substituted alkyl, C.sub.2 to C.sub.7 substituted alkenyl, C.sub.2 to C.sub.7 substituted alkynyl, C.sub.1 to C.sub.7 alkoxy, C.sub.1 to C.sub.7 substituted alkoxy, C.sub.1 to C.sub.7 acyloxy, C.sub.1 to C.sub.7 acyl, C.sub.3 to C.sub.7 cycloalkyl, C.sub.3 to C.sub.7 substituted cycloalkyl, C.sub.5 to C.sub.7 cycloalkenyl, C.sub.5 to C.sub.7 substituted cycloalkenyl, a heterocyclic ring, C.sub.7 to C.sub.12 phenylalkyl, C.sub.7 to C.sub.12 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, carboxamide, protected carboxamide, C.sub.1 to C.sub.4 alkylthio, C.sub.1 to C.sub.4 substituted alkylthio, C.sub.1 to C.sub.4 alkylsulfonyl, C.sub.1 to C.sub.4 substituted alkylsulfonyl, C.sub.1 to C.sub.4 alkylsulfoxide, C.sub.1 to C.sub.4 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl and substituted phenylsulfonyl; orone or more of adjacent position pairs R.sup.3 and R.sup.4, R.sup.4 and R.sup.5, and R.sup.5 and R.sup.6 together form a group that is, independently, selected from cyclic C.sub.2 to C.sub.7 alkylene, substituted cyclic C.sub.2 to C.sub.7 alkylene, cyclic C.sub.2 to C.sub.7 heteroalkylene and substituted cyclic C.sub.2 to C.sub.7 heteroalkylene, wherein said group is bonded to the phenyl ring depicted in Formula I;R.sup.7 and R.sup.8 are, independently, selected from the group consisting of a hydrogen atom, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 substituted alkyl, C.sub.1 to C.sub.7 acyl, C.sub.1 to C.sub.7 substituted acyl, phenylsulfonyl, substituted phenylsulfonyl, C.sub.1 to C.sub.4 alkylsulfonyl, C.sub.1 to C.sub.4 substituted alkylsulfonyl, C.sub.1 to C.sub.6 alkylaminocarbonyl, C.sub.1 to C.sub.6 substituted alkylaminocarbonyl, phenylaminocarbonyl, and substituted phenylaminocarbonyl; andY is C(O)NHR.sup.9, wherein R.sup.9 is a hydrogen atom, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 substituted alkyl; ora salt of the tetrahydro-quinoline compounds.