Patent ID: 6391891
Filing Date: 2002-05-21
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a salt thereof: in which Ra is a group of formula (i) in which P1 is phenyl, bicyclic aryl, a 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur;R1 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, nitro, trifluoromethyl, cyano, SR9, SOR9, SO2R9, SO2NR10R11, CO2R10, CONR10R11, CONR10(CH2)cCO2R11, (CH2)cNR10R11, (CH2)cCONR10R11, (CH2)cNR10COR11, (CH2)cCO2C1-6alkyl, CO2(CH2)cOR10, NR10R11, NR10CO2R11, NR10CONR10R11, CR10&boxH;NOR11 where R9 is C1-6alkyl, R10 and R11 are independently hydrogen or C1-6alkyl and c is 1 to 4; R2 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-6alkoxy, COC1-6alkyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R10, CONR10R11, NR10R11 where R10 and R11 are as defined for R1; a is 1,2 or 3; or Ra is a group of formula (ii) â€ƒwherein P2 and P3 are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur; A is a bond or oxygen, S(O)m where m is 0, 1 or 2, carbonyl, or CH2 or NR4 where R4 is hydrogen or C1-6alkyl; R1 is as defined above for formula (i) or is a 5 to 7-membered heterocyclic ring, containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur, optionally substituted by C1-6alkyl, halogen or C1-6alkanoyl; R2 and R3 are as defined for R2 in formula (i); and a and b are independently 1, 2 or 3; L is a group of formula â€”Yâ€”C(&boxH;V)â€”DGâ€”â€ƒin which Y is â€”NHâ€”,; V is oxygen or sulphur; D is nitrogen; G is hydrogen or C1-6alkyl; Q is thienyl; Ry is a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur; Rb is hydrogen, halogen, hydroxy, C1-6alkyl, trifluoromethyl, C1-6alkoxy or aryl;