Patent ID: 8846000
Filing Date: 2014-09-30
Classification: A61K,A61P,C07D

Abstract:
1. A radiolabeled compound which is 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-[2-(3-biphenyl-3-yl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl]-1H-isoindole-1,3(2H)-dione, 2-{2-[7-chloro-3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-methyl-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-5-methyl-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1,3-dioxoisoindoline-4-carbonitrile, 4-methoxy-2-{2-[7-methoxy-3-(3-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 4-methoxy-2-{2-[3-(4-methoxyphenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, tert-butyl 3-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-indole-1-carboxylate, N-biphenyl-2-yl-N′-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}urea, 4-isopropoxy-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-(2-{3-[4-(2-fluoroethoxy)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl)-4-isopropoxy-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(1H-indol-6-yl)-7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-isopropoxy-1H-isoindole-1,3(2H)-dione, 4-isopropoxy-2-{2-[7-methoxy-3-(3-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(1H-indazol-6-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-4-isopropoxy-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-pyridin-4-yl-1H-isoindole-1,3(2H)-dione, 2-{[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione, 2-{3-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]propyl}-1H-isoindole-1,3(2H)-dione, 2-{3-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(2,2,2-trifluoroethoxy)-1H-isoindole-1,3(2H)-dione, 4-(cyclopropylmethoxy)-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 4-(cyclobutyloxy)-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-7-methyl-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-4-(2,2,2-trifluoroethoxy)-1H-isoindole-1,3(2H)-dione 4-methoxy-2-{2-[3-(1-methyl-1H-indazol-6-yl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-{2-(3-(4-methoxyphenyl)-7-methyl-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione 2-[2-(3-cyclohexyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl]-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione 4-hydroxy-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 4-methoxy-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(1,3-oxazol-2-yl)-1H-isoindole-1,3(2H)-dione, 2-(2-{3-[4-(benzyloxy)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl)-4-isopropoxy-1H-isoindole-1,3(2H)-dione 2-{2-[3-(4-hydroxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-isopropoxy-1H-isoindole-1,3(2H)-dione 4-isopropoxy-2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione, 2-methoxy-N-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-benzamide, 2-{2-[3-(1H-indazol-6-yl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione, 2-{2-[7-methyl-3-(1-methyl-1H-indazol-6-yl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione, or a pharmaceutically acceptable salts thereof wherein the radiolabeled compound is radiolabeled with