Patent ID: 8008000
Filing Date: 2011-08-30
Classification: A61K,A61P,C07K,C12N,C12Q

Abstract:
1. A method for determining whether an HBV strain exhibits reduced sensitivity to Adefovir said method comprising isolating DNA or corresponding mRNA from the HBV strain and screening for the presence of a mutation in the nucleotide sequence encoding the HBV DNA polymerase resulting in a substitution in the amino acid sequence of the HBV DNA polymerase selected from the group consisting of rtQ215S and rtV253G, wherein the foregoing amino acid positions are numbered in reference to the M of the YMDD motif of the HBV DNA polymerase being position 204 and wherein the presence of said mutation is indicative of an HBV variant that exhibits a decreased sensitivity to Adefovir.