Patent ID: 6792336
Filing Date: 2004-09-14
Classification: C22B,G05B,Y02P

Abstract:
A method of controlling a bioreactor comprising:establishing in an expert controller a split data distribution for at least one input variable, the split data distribution having a mean of N and a standard deviation, an upper limit, and a lower limit; running the bioreactor according to the at least one input variable as controlled by a biocontroller and first measuring at a diagnostic system at least one output variable from the reactor; changing in the expert controller a value of the at least one input variable from the mean to a new input variable value, N+1, to create a difference (N+1)âˆ’N; running the bioreactor according to the value of the it least one input variable as controlled by the biocontroller and second measuring at the diagnostic system the at least one output variable from the bioreactor, and if the at least one output variable is improved, in the expert controller: changing the mean of the at least one input variable to the new input variable value, N+1; changing the upper limit; and changing the lower limit, wherein a one of the upper and lower limit that is approached by the direction of the difference is changed more than a one of the upper and lower limit that is distanced by the direction of the difference; and if the at least one output variable is not improved, in the expert controller: not changing the mean of the at least one input variable; changing a one of the upper and lower limit that is approached by the direction of the difference by decreasing it; and not changing a one of the upper and lower limit that is distanced by the direction of the difference.