Patent ID: 6162794
Filing Date: 2000-12-19
Classification: C07H

Abstract:
A compound of the formula: ##STR6## or a pharmaceutically acceptable salt thereof, wherein: R is H, R.sup.1, C(.dbd.O) R.sup.1, C(.dbd.O) OR.sup.1, (CH.sub.2).sub.m R.sup.3, or is absent, wherein m is an integer from 0 to 6;R.sup.3 is a 5-10 membered heterocycle or C.sub.6 -C.sub.10 aryl, wherein said heterocyclic and aryl groups are optionally substituted by 1 to 3 substituents independently selected from the group consisting of --C(O)OR.sup.4, --OR.sup.4, C.sub.1 -C.sub.6 aklanoyl, halo, nitro, cyano, C.sub.1 -C.sub.6 alkyl, --NR.sup.4 R.sup.5, --S(C.sub.1 -C.sub.6 alkyl), --SO(C.sub.1 -C.sub.6 alkyl), --SO.sub.2 (C.sub.1 -C.sub.6 alkyl) and --SO.sub.2 NR.sup.4 R.sup.5 ;each R.sup.4 and R.sup.5 is independently the group consisting of H and C.sub.1 -C.sub.10 alkyl, saturated or unsaturated, wherein one or two carbons of said alkyl are optionally replaced by a heteroatom selected from O, S and N;R.sub.1 is selected from the group consisting of saturated C.sub.1 -C.sub.10 alkyl and unsaturated C.sub.1 -C.sub.10 alkyl, wherein one or two carbons of said alkyl are optionally replaced by a heteroatom selected from O, S and N, and are optionally substituted by 1 to 3 substituents selected from the group consisting of --C(O)OR.sup.4, --OR.sup.4, C.sub.1 -C.sub.6 alkanoyl, halo, nitro, cyano, C.sub.1 -C.sub.6 alkyl, 5-10 membered hetercycle, C.sub.6 -C.sub.10 aryl, --NR.sup.4 R.sup.5, --S(C.sub.1 -C.sub.6 alkyl), --SO(C.sub.1 -C.sub.6 alkyl), --SO.sub.2 (C.sub.6 alkyl) and --SO.sub.2 NR.sup.4 R.sup.5 ; andZ is H, C(.dbd.O)R.sup.4 or C(.dbd.O)R.sup.3, wherein R.sup.4 is defined as above.