Patent ID: 6991902
Filing Date: 2006-01-31
Classification: C07D,C07H,C40B

Abstract:
1. A method for preparing a library of compounds of the formula wherein: each tether moiety T is —NHR R each chemical substituent L is, independently, C contacting a purine heterocyclic scaffold having two functionalizable atoms, wherein one of said functionalizable atoms is blocked, with a mixture of at least six different chemical substituents to append said chemical substituents to said heterocyclic scaffold directly to form a substituent-appended scaffold; deblocking said blocked functionalizable atom of said substituent-appended scaffold; and contacting said substituent-appended scaffold with a mixture ofat least six different chemical sub stituents to append said chemical substituents to said substituent-appended scaffold via a tether moiety covalently attached to one of said functionalizable atoms.