Patent ID: 8318748
Filing Date: 2012-11-27
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of treating osteoporosis in a mammal in need thereof by administering to the mammal a therapeutically effective amount of a compound of the following chemical formula: wherein R 1 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with one to six halo, C 3-6 cycloalkyl, —SR 9 , —SR 12 , —SOR 9 , —SOR 12 , —SO 2 R 9 , —SO 2 R 12 , —SO 2 CH(R 12 )(R 11 ), —OR 12 , —OR 9 , —N(R 12 ) 2 , aryl, heteroaryl or heterocyclyl wherein said aryl, heteroaryl and heterocyclyl groups are optionally substituted with one or two substitutents independently selected from C 1-6 alkyl, halo, hydroxyalkyl, hydroxy, alkoxy or keto; R or R R R or R R R each D is independently C R wherein said groups are optionally substituted on either the carbon or the heteroatom with one to five substituents independently selected from C R or R R R R R R R or R R R or R n is independently selected from an integer from one to three; each m is independently selected from an integer from zero to two; and the pharmaceutically acceptable salts and stereoisomers thereof.