Patent ID: 7674614
Filing Date: 2010-03-09
Classification: C07B,C07D,C12C,Y10T

Abstract:
1. A method for optically resolving an alcohol of the formula (3): wherein R 11 , R 12 , and R 13 individually represent a hydrogen atom or a substituted or unsubstituted alkyl group having 1-20 carbon atoms, provided that at least one of R 11 , R 12 , and R 13 is not a hydrogen atom, the method comprising: a step of reacting at least one of the compounds having the following formula (1) or (2): wherein R 1 -R 8 individually represent a hydrogen atom or an alkyl group having 1-20 carbon atoms, R 9 represents a substituted or unsubstituted alkyl group having 1-20 carbon atoms, a substituted or unsubstituted alkenyl group having 1-20 carbon atoms, formyl group, or an acyl group, and R 10 represents an alkyl group having 1-6 carbon atoms, provided that the R 9 group and the OR 10 group are cis-configured with an optical isomer mixture of an alcohol having an asymmetric carbon atom in the molecule of the formula (3) to obtain a diastereomer mixture of the formula (4): wherein R 1 -R 13 are the same as defined above, * represents an asymmetric carbon atom, and a R 9 group and a OC(R 11 )(R 12 )(R 13 ) group are cis-configured, a step of separating the resulting diastereomer mixture of the formula (4) into individual diastereomers, and a step of reacting the separated diastereomer with an alcohol of the formula, R