Patent ID: 6747037
Filing Date: 2004-06-08
Classification: A61K,C07D

Abstract:
A method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective amount of a compound represented by the general formula wherein hatched lines represent the &agr; configuration, a triangle represents the &bgr; configuration, a wavy line represents either the &agr; configuration or the &bgr; configuration and a dotted line represents the presence or absence of a double bond;D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R, SONR2 or Z is CH2 or a covalent bond; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl or alkenyl and R3 is selected from the group consisting of R2, phenyl, thienyl, furanyl, pyridyl, benzothienyl, benzofuranyl, naphthyl, or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR.