Patent ID: 6331318
Filing Date: 2001-12-18
Classification: A61K,A61P,C07C,Y10S

Abstract:
A delivery composition comprising of:(a) an active agent; and(b) at least one diketopiperazine having the formula: ##STR5##wherein R.sup.1 and R.sup.2 are hydrogen, C.sub.1 -C.sub.24 alkyl, C.sub.1 -C.sub.24 alkenyl, phenyl, naphthyl, (C.sub.1 -C.sub.10 alkyl)phenyl, (C.sub.1 -C.sub.10 alkenyl)phenyl, (C.sub.1 -C.sub.10 alkyl)naphthyl, (C.sub.1 -C.sub.10 alkenyl)naphthyl, phenyl (C.sub.1 -C.sub.10 alkyl), phenyl (C.sub.1 -C.sub.10 alkenyl), naphthyl (C.sub.1 -C.sub.10 alkyl), or naphthyl (C.sub.1 -C.sub.10 alkenyl);both R.sup.1 and R.sup.2, optionally, are substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, --OH, --SH, and --CO.sub.2 R.sup.3 or any combination thereof; wherein R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, or C.sub.1 -C.sub.4 alkenyl;R.sup.1 and R.sup.2, optionally, are interrupted by oxygen, nitrogen, sulfur, or any combination thereof;said phenyl, naphthyl, or phenyl and naphthyl groups, optionally, are substituted by C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkoxy, --OH, --SH, or CO.sub.2 R.sup.4 wherein R.sup.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkenyl; andR.sup.1 and R.sup.2 are not both hydrogen.