Patent ID: 7955804
Filing Date: 2011-06-07
Classification: A61P,C07K,C12N,G01N

Abstract:
1. A method of diagnosis of a brain damage-related disorder in a subject suspected of having a brain damage-related disorder, which comprises: detecting levels of two or more polypeptides comprising H-FABP and Glutathione S transferase P in a sample of body fluid taken from the subject suspected of having a brain damage-related disorder, wherein the body fluid is selected from the group consisting of cerebrospinal fluid, plasma, serum, and blood; detecting levels of the same two or more polypeptides comprising H-FABP and Glutathione S transferase P in a comparative sample of body fluid taken from a subject known not to have a brain damage-related disorder, wherein the body fluid is the same type of body fluid as the sample from the subject suspected of having a brain damage-related disorder; comparing the levels of the two or more polypeptides in the sample of body fluid taken from the subject suspected of having a brain damage-related disorder with the levels of the same two or more polypeptides in the comparative sample; and determining whether the subject suspected of having a brain damage-related disorder has a brain damage-related disorder based on said comparison, wherein each of the two or more polypeptides is detected in significantly higher amounts in the body fluid of brain damage-related disorder-affected subjects than are detected in the body fluid of non-brain damage-related disorder-affected subjects, whereby the detection of significantly higher amounts of the two or more polypeptides in the body fluid sample is indicative of a brain damage-related disorder.