Patent ID: 6479482
Filing Date: 2002-11-12
Classification: C07D

Abstract:
A compound of Formula I and its pharmaceutically acceptable acid addition salts or hydrates thereof whereinX is CH; R1 and R4 are independently selected from lower alkyl and CO2R6 where R6 is lower alkyl; R2 and R3 are independently selected from lower alkyl; R5 is hydrogen or halogen; n is an integer selected from 2 to 5; Z is m is zero or the integer 1 or 2; and, R7 and R8 are independently selected from the group consisting of hydrogen, furfuryl, tetrahydrofurfuryl, thienyl, azetidinyl, or R7 and R8 are taken together to form â€”(CH2CH2)2â€”S&boxH;Om, R7 and R8 can not be both hydrogen.