Patent ID: 6355674
Filing Date: 2002-03-12
Classification: C07C,C07D

Abstract:
A compound of the formula (I) wherein:R1 and R2 are each individually hydrogen or â€”(C1-C6)alkyl; R3 is â€”(C2-C8)alkenyl, â€”(CH2)q(C3-C8)cycloalkyl, â€”(CH2)nO(CH2)pR5, â€ƒor â€ƒsubstituted with one substituent selected from the group consisting of â€”(C1-C6)alkyl and â€”(C3-C8)cycloalkyl; â€ƒwhere Aâ€”B is >C&boxH;CHâ€” or >CR4CH2â€”; D is â€”CH2â€” or oxygen; R4 is hydrogen or â€”OH; R5 is â€”(C3-C8)cycloalkyl, or phenyl substituted with one substituent selected from the group consisting of halo, â€”(C1-C6)alkyl and (C1-C6)alkoxy; m is an integer from 1 to 5 both inclusive; n is an integer from 0 to 4 both inclusive; p is an integer from 1 to 7 both inclusive; and q is an integer from 0 to 4 both inclusive; or a pharmaceutically acceptable salt or optical isomer thereof; provided that when D is oxygen, >Aâ€”B is not >C&boxH;CHâ€”; and when R4 is â€”OH, D is not oxygen.