Patent ID: 6057346
Filing Date: 2000-05-02
Classification: A61K,A61P

Abstract:
A method of inhibiting the activity of an LTR promoter in a T cell comprising contacting said T cell containing an LTR promoter with an amount of a calcium response modifier compound effective to inhibit the activity of the LTR promoter where the calcium response modifier compound is selected from the group of calcium response modifier compounds with the formula:Y--(CH.sub.2).sub.p --Ar.sup.1 --X--Ar.sup.2 (I)wherein:p is an integer of from 0 to 4;Ar.sup.1 and Ar.sup.2 are each aromatic moieties independently selected from the group consisting of phenyl, naphthyl, and substituted versions thereof;X is a linking moiety selected from the group consisting of O, S, SO.sub.2, CO, CHCN, straight chain alkyl, alkoxy, and alkosyalkyl;Y is a nitrogen-containing heterocyclic moiety selected from the group consisting of:radicals of the formula ##STR6## wherein: A is N or CH;R.sup.1 is a member selected from the group consisting of hydrogen, --CONH.sub.2, --CONHR.sup.5, --CO.sub.2 H, --CO.sub.2 R.sup.5, and --SO.sub.2 NH.sub.2 ;R2 is a member selected from the group consisting of hydrogen, amino, --NHCOC.sub.6 H.sub.5, --NHCOR.sup.5, --NHCHO, --NHR.sup.5, and --N(R.sup.5).sub.2 ;R.sup.5 is a lower alkyl of from 1 to 6 carbon atoms, and(b) 1,2,4-triazolyl, pyrazinyl, purinyl, pyrimidinyl, 1,2,3-triazolo{4,5-d}-pyrimidinyl, and substituted versions thereof.