Patent ID: 8354440
Filing Date: 2013-01-15
Classification: A61P,C07D

Abstract:
1. A method of inhibiting translation initiation in a cell comprising contacting the cell with a compound of formula II, formula IX, X, XI, XII, XIII or XIV wherein the compound of formula II is: wherein R the compound of formula IX is: wherein R is selected from the group consisting of —CH the compound of formula X is: the compound of formula XI is: the compound of formula XII: the compound of formula XIII: wherein R is selected from the group consisting of 2-Thiophene, —(CH 2 ) 11 CH 3 , —CH 2 Ph, —CCH, -cyclohexyl and —C 6 F 5 ; and the compound of formula XIV is: wherein R is selected from the group consisting of H, 3-Cl, 3-F, 3-Me and 3-t-Bu.