Patent ID: 8597636
Filing Date: 2013-12-03
Classification: A61K,C07K

Abstract:
1. A method for treating an immune thrombocytopenia or inflammatory arthritis in a mammal, said method comprising: a) obtaining a sample of leukocytes having a Fcγ receptor and being syngeneic or autologous to the cells of the treated mammal; b) contacting said leukocytes of step a) with an antibody composition binding to a γ-chain dependent Fcγ receptor under conditions sufficient to allow the crosslinking of the γ-chain dependent Fcγ receptor; and c) administering said leukocytes of step b) to said mammal; wherein said treated leukocytes ameliorate said immune thrombocytopenia or inflammatory arthritis in said mammal; wherein the antibody composition is selected from the group consisting of i) an IVIg, ii) a combination of an antibody specific for the FcγRIIIA receptor and an anti-IgG antibody, and iii) an immune complex comprising an antigen and an IgG antibody specific for the antigen.