Patent ID: 7018819
Filing Date: 2006-03-28
Classification: A61K,C12M,C12N

Abstract:
1. A method for electromanipulation of at least one cell or cell-like structure having cell-like membranes, comprising the following consecutive steps: (a) at least one cell or cell-like structure is transported from one or more sample containers located on a chip through at least one microchannel located on said chip into a chamber located on said chip, wherein said chamber contains at least one microelectrode connected to a voltage generator, and wherein said microchannel provides a fluid contact between the sample containers, (b) either said at least one cell or cell-like structure is placed or aligned close to said at least one electrode, or said at least one microelectrode is placed or aligned close to said at least one cell or cell-like structure in said chamber, (c) an electrical field is applied and focused on said at least one cell or cell-like structures, said electrical field being of a strength sufficient to obtain pore-formation in said at least one cell or cell-like structure or sufficient to obtain fusion of said at least one cell or cell-like structure with another cell or cell-like structures in said chamber.