Patent ID: 6107345
Filing Date: 2000-08-22
Classification: A61P,C07C,C07D

Abstract:
A compound selected from those of formula (I): ##STR26## wherein: Z.sub.1, Z.sub.2, Z.sub.3 and Z.sub.4, which may be identical or different, each represents hydrogen, halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.2 -C.sub.6)alkenyl, linear or branched (C.sub.2 -C.sub.6)alkynyl, (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.6)alkyl the alkyl moiety of which is linear or branched, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, benzyloxy-(C.sub.2 -C.sub.6)-alkenyloxy, the alkenyl moiety of which is linear or branched, linear or branched (C.sub.2 -C.sub.6)alkynyloxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, a group of formula --OSO.sub.2 CF.sub.3, OSO.sub.2 CH.sub.3, --NHCOCH.sub.3, --NHCOCF.sub.3, --NHSO.sub.2 CH.sub.3, ##STR27## or a group of formula ##STR28## wherein R.sub.1 and R.sub.2, which may be identical or different, each represents hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.2 -C.sub.6)alkenyl, linear or branched (C.sub.2 -C.sub.6)alkynyl, aryl-(C.sub.1 -C.sub.6)alkyl, the alkyl moiety of which is linear or branched, or (C.sub.3 -C.sub.8)cycloalkyl-(C.sub.1 -C.sub.6)alkyl the alkyl moiety of which is linear or branched,X represents:oxygen,S(O).sub.p wherein p represents 0 to 2 inclusive,--(CH.sub.2).sub.n wherein n represents 1 to 4 inclusive,or --CH.sub.2 --Y--CH.sub.2 -- wherein Y represents oxygen, selenium, ##STR29## wherein p is as defined above, ##STR30## wherein R.sub.1 and R.sub.2 are as defined above, A represents: ##STR31## wherein R.sub.1 and R.sub.2 are as defined above,m represents 1 to 6 inclusive, andG represents oxygen or NH,its isomers and pharmaceutically acceptable acid addition salts thereof.