Patent ID: 6566509
Filing Date: 2003-05-20
Classification: A61K,A61P,C07C,C07D,C07H,C12Q,C40B,G01N,Y02A,Y10S

Abstract:
A compound of the formula:Lâ€²â€”Xâ€²â€”Lâ€³or a pharmaceutically-acceptable salt thereof; wherein Lâ€² is selected from the group consisting of: Lâ€³ is a moiety of formula: Xâ€² has the formula: â€”Xaâ€”Zâ€”(Yaâ€”Z)mâ€”Ybâ€”Zâ€”Xaâ€”â€ƒwherein m is an integer of from 0 to 20; Xa at each separate occurrence is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”NRâ€”, â€”C(O)â€”, â€”C(O)Oâ€”, â€”C(O)NRâ€”, â€”C(S), â€”C(S)Oâ€”, â€”C(S)NRâ€” and a covalent bond where R is as defined below; Z is at each separate occurrence is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cylcoalkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, cycloalkenylene, substituted cycloalkenylene, arylene, heteroarylene, heterocyclene, and a covalent bond;, Ya and Yb at each separate occurrence are selected from the group consisting of â€”C(O)NRâ€²â€”, â€”NRâ€²C(O)â€”, â€”NRâ€²C(O)NRâ€²â€”, â€”C(&boxH;NRâ€²)â€”NRâ€²â€”, â€”NRâ€²C(&boxH;NRâ€²)â€”, â€”NRâ€²C(O)â€”Oâ€”, â€”P(O)(ORâ€²)â€”Oâ€”, â€”S(O)nCRâ€²Râ€³â€”, â€”S(O)nâ€”NRâ€²â€”, â€”Sâ€”Sâ€” and a covalent bond; where n is 0, 1 or 2; and R,Râ€² and Râ€³ at each separate occurrence are selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl and heterocyclic.