Patent ID: 6596503
Filing Date: 2003-07-22
Classification: A61K,A61P,C07K,G01N

Abstract:
A method of screening for the presence of epithelial cancer in a human subject, comprising the steps of:contacting a biological sample taken from said subject with an antibody selected from the group consisting of a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 and fragments of the foregoing which specifically bind the epitope bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449, under conditions permitting said antibody to specifically bind an antigen in the sample to form an antibody-antigen complex; and then determining the amount of antibody-antigen complex in the sample as a measure of the amount of antigen in the sample, wherein an elevated level of the antigen in the sample as compared to control is associated with the presence of epithelial cancer in said subject.