Patent ID: 8450071
Filing Date: 2013-05-28
Classification: G01N,Y10S

Abstract:
1. A method of detecting in a subject, a chronic inflammatory-associated disease selected from the group consisting of osteoarthritis and atherosclerosis, comprising: analyzing a sample of at least one of serum and plasma obtained from the subject to isolate and measure an amount of an isoform of endothelial CAP37 protein in the sample, wherein the isoform of endothelial CAP37 protein has an apparent molecular weight of about 135 kDa ±15 kDa as assessed by SDS PAGE under reducing conditions, wherein the isoform of endothelial CAP37 protein is isolated by binding to monoclonal antibody D5F10, and wherein the subject does not have an active acute infection; and correlating the presence of the isoform of endothelial CAP37 protein with the presence of the chronic inflammatory-associated disease selected from the group consisting of osteoarthritis and atherosclerosis in the subject when the isoform of endothelial CAP37 protein is present in an amount which is at least twice an amount of the isoform calculated as an average of said isoform found in a control population.