Patent ID: 7579019
Filing Date: 2009-08-25
Classification: A61K,A61P

Abstract:
1. A method for the transmucosal delivery of a systemic pharmaceutical for achieving a fast onset of activity in a subject or a desired level of a systemic pharmaceutical in the blood of a subject, comprising: adhering a bioerodable device to an oral mucosa surface of a subject such that there is minimal foreign body sensation; and directionally delivering an amount of a systemic pharmaceutical from the bioerodable device to mucosal tissue of the subject such that an effective amount of the systemic pharmaceutical is delivered to the subject achieving a fast onset of activity in the subject or a desired level of the systemic pharmaceutical in the blood of the subject within about 30 minutes, wherein the bioerodable device has a residence time of less than 1 hour or about 1 hour, and the device comprises a thin and flexible adherent and bioerodable polymeric film containing a systemic pharmaceutical, and wherein the bioerodable device comprises soluble polymers selected based on dissolution rates to achieve the desired residence time and release profile.