Patent ID: 6069254
Filing Date: 2000-05-30
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula: ##STR18## wherein: R.sub.10 is H or C(O)N(R.sup.1)YZ, whereinR.sup.1 is H; Y is (CH.sub.2).sub.p, (CH.sub.2).sub.q CHR.sup.3 or CH(R.sup.3)(CH.sub.2).sub.q,wherein R.sup.3 is aryl, aralkyl or heteroaryl, q is 1-3 and p is 2 or 3;Z is CO.sub.2 H, CO.sub.2 -alkyl, or 5-tetrazole;X is C(O);M is (CH.sub.2).sub.m or piperidin-1-yl, wherein m is 2;n is 2;R.sub.5 is H;A is selected from any of piperidin-2-yl, piperidin-3-yl, piperidin-4-yl or ##STR19## wherein R.sub.9 is H enantiomers and the pharmaceutically acceptable salts thereof alkyl, CH(NH), CMe(NH) or acyl.