Patent ID: 6313092
Filing Date: 2001-11-06
Classification: A61K,A61N,C07K

Abstract:
A method of making an analog of a parent polypeptide having enhanced electrotransportability, wherein said parent polypeptide has an amino acid sequence of 10 to 50 amino acid residues and at least one .alpha.-helical segment, said method comprising the steps of:a. determining the amino acid sequence for said parent polypeptide;b. establishing a modified sequence of amino acids by replacing one or more amino acids in the .alpha.-helical segment of the parent polypeptide sequence with a substituted amino acid wherein the P.alpha. value of the substituted amino acid is less than the P.alpha. value for the amino acid that was replaced in the parent polypeptide sequence; andc. producing the analog comprising the modified sequence established in step b.