Patent ID: 6680202
Filing Date: 2004-01-20
Classification: B01J,Y10S,Y10T

Abstract:
A method for synthesizing a plurality of chemical compounds simultaneously and to synthesize a series of plurality of simultaneously synthesized chemical compounds sequentially utilizing a dynamic matrix system, which comprises:A. providing apparatus which includes: a. a base support structure having a plurality of reaction vessels arranged in at least a two dimensional predetermined array, each of said reaction vessels having sufficient wall and bottom structure to support and contain a liquid reactant mixture, each of said reaction vessels adapted to receive physical chemistry teabags therein for chemical synthesis; b. a physical chemistry teabag support structure adapted to hold and support a plurality of physical chemistry teabags arranged in at least a two dimensional predetermined teabag array, corresponding to said base support structure reaction vessel array; c. a plurality of physical chemistry teabags, said plurality of physical chemistry teabags having at least one predetermined fixed reactant thereon; d. a fixed-reactant/liquid reactant mixture shifting means adapted to alter specific fixed reactant-liquid reactant mixture combinations for at least a portion of said plurality of physical chemistry teabags relative to the liquid reactant mixture content of said plurality of reaction vessels, said fixed reactant-liquid reactant mixture shifting means being a dynamic fluid flow system and each of said plurality of reaction vessels includes at least one liquid channel connected thereto and connected to valve and supply means for filling and draining said plurality of reaction vessels with a sequence of different liquid reactant mixture arrays, each of said different reactant mixture arrays having at least one liquid reactant mixture; and, e. programmable flow means to provide for simultaneous and sequential filling and draining said plurality of reaction vessels with a plurality of different liquid reaction mixtures for each of a plurality of different fixed-reactant/liquid reactant mixture combination array sequences; B. providing said plurality of reaction vessels with a plurality of different liquid reactant mixtures; C. operating said fixed-reactant/liquid reactant mixture shifting means so as to insert said plurality of physical chemistry teabags into said plurality of reaction vessels in a first position matrix for a sufficient holding time to create at least a first chemical compound synthesis; D. operating said fixed-reactant/liquid mixture shifting means so as to remove said plurality physical chemistry teabags from said plurality of reaction vessels; and, E. operating said fixed-reactant/liquid mixture shifting means so as to relocate at least one of said plurality of physical chemistry teabags relative to said plurality of reaction vessel and subsequently inserting said plurality of physical chemistry teabags into said plurality of reaction vessels in a second position matrix so that at least one of said physical chemistry teabags is positioned in a different reaction vessel from the reaction vessel of the first position matrix for a sufficient holding time to create at least a second chemical compound synthesis.