Patent ID: 8445514
Filing Date: 2013-05-21
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): wherein: A is a-2, wherein, the lower portion of A is attached, relative to the nitrogen atom of Formula (I), to the 3 or 4 position on the benzene ring portion of Formula (I); wherein, G is hydrogen, or one substituent selected from C or two C 1-4 alkyl substituents both attached to the common ring nitrogen atom of Formula (I), thus forming a quaternary ammonium salt; R R L is absent or C D is aryl, C wherein aryl and heteroaryl are optionally substituted with one, two, three or four substitutents independently selected from the group consisting of C L R wherein phenyl is optionally substituted with [(R wherein heterocyclyl is optionally substituted with C wherein C R R R wherein C wherein heteroaryl having a nitrogen atom ring member is optionally substituted on the ring nitrogen atom with an oxy substituent and thus forms an oxide; R wherein aryl, heteroaryl, C wherein C wherein heteroaryl having a nitrogen atom ring member is optionally substituted on the ring nitrogen atom with an oxy substituent and thus forms an oxide; R B is C wherein B is optionally substituted with one, two or three substituents independently selected from the group consisting of C provided that when B is selected from the group consisting of C provided that, when B is phenyl substituted at the 3,4-, 3,5- or 4,5-positions with an unbranched C E is hydrogen, halogen, cyano, C X is O or S; and enantiomers, diastereomers, tautomers, and pharmaceutically acceptable salts thereof.