Patent ID: 6051572
Filing Date: 2000-04-18
Classification: C07D

Abstract:
A compound of formula I, or a salt or prodrug thereof: ##STR23## wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole;E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;Q represents a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally substituted in any position by a hydroxy group;T represents CH;U represents C--R.sup.2 ;V represents N--R.sup.3 ;R.sup.2 and R.sup.3 independently represent hydrogen or C.sub.1-6 alkyl;M represents the, residue of an azetidine, pyrrolidine or piperidine ring;R represents a group of formula --W--R.sup.1 ;W represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; andR.sup.1 represents a group of formula (a), (b), (c) or (d): ##STR24## in which Y represents oxygen or N--R.sup.5 ;R.sup.4 represents hydrogen, halogen, cyano, nitro, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, C.sub.2-6 alkylcarbonyl, amino, C.sub.1-6 alkylamino, di(C.sub.1-6)alkylamino, C.sub.2-6 alkylcarbonylamino, C.sub.1-6 alkylsulphonylamino or C.sub.1-6 alkylaminosulphonylmethyl; andR.sup.5 represents hydrogen or C.sub.1-6 alkyl.