Patent ID: 7776865
Filing Date: 2010-08-17
Classification: A61P,C07D

Abstract:
1. A compound represented by the structural formula (I): or a pharmaceutically acceptable salt of the compound of Formula (I), wherein: R wherein each of the alkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, haloalkyl, heteroaryl, cycloalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, and alkynylalkyl groups and the heterocyclic moieties shown immediately above for R 2 can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, cycloalkyl, —CF 3 , —CN, —OCF 3 , —(CR 11 R 11 ) p OR 5 , —OR 5 , —NR 5 R 6 , —(CR 5 R 11 ) p NR 5 R 6 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 6 , —SR 6 , —S(O 2 )R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —CH(═N—OH), —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 , with the proviso that no carbon adjacent to a nitrogen atom on a heterocyclyl ring carries a —OR 5 moiety; R wherein each of the alkenyl, alkynyl; cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, and the heterocyclic moieties whose structures are shown immediately above for R 3 can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, cycloalkyl, —CF 3 , —CN, —OCF 3 , —(CR 11 R 11 ) p OR 5 , —OR 5 , —NR 5 R 6 , —(CR 5 R 11 ) p NR 5 R 6 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 6 , —CH(═N—OH), SR 6 , —S(O 2 )R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 , with the proviso that no carbon adjacent to a nitrogen atom on a heterocyclyl ring carries a —OR 5 moiety; R wherein each of the alkyl, cycloalkyl; heterocyclyl, heterocyclylalkyl, aryl, fused aryl, heteroaryl and fused heteroaryl groups of R 4 can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, cycloalkyl, —CF 3 , —CN, —OCF 3 , —(CR 11 R 11 ) p OR 5 , —OR 5 , —NR 5 R 6 , —(CR 5 R 11 ) p NR 5 R 6 , —C(O 2 )R 5 , —C(O 2 )R 5 , —C(R 5 )(═N—OR 5 ), —C(O)NR 5 R 6 , —SR 6 , —S(O 2 )R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 , with the proviso that no carbon adjacent to a nitrogen atom on a heterocyclyl ring carries a —OR 5 moiety, and wherein the substituted alkyl group of R 4 is independently substituted with one or more of the above moieties; R R R R R R R R R m is 0 to 4; n is 1 to 4; and p is 1 to 4; wherein Boc means butoxycarbonyl, with the provisos that (1) when R wherein each of the alkynyl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, and the heterocyclic moieties whose structures are shown immediately above for R 3 is unsubstituted or independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of —CN, —NR 5 R 6 , —(CR 5 R 11 ) p NR 5 R 6 , —C(O)NR 5 R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 ; and (2) when R wherein each of the cycloalkyl, heterocyclyl, heterocyclylalkyl, and the heterocyclic moieties whose structures are shown immediately above for R 3 can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, cycloalkyl, —CF 3 , —CN, —OCF 3 , —(CR 11 R 11 ) p OR 5 , —OR 5 , —NR 5 R 6 , —(CR 5 R 11 ) p NR 5 R 6 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 6 , —SR 6 , —S(O 2 )R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 , with the proviso that no carbon adjacent to a nitrogen atom on a heterocyclyl ring carries a —OR 5 moiety.