Patent ID: 8173818
Filing Date: 2012-05-08
Classification: C07D

Abstract:
1. A process for producing sulphoxide compound of Formula I in an enantiomerically enriched form, wherein ring A is a benzene ring optionally having 1 to 3 substituent (s) selected from a C R R X is a nitrogen atom, Y is a nitrogen atom the process comprising: asymmetrically oxidizing a prochiral sulphide of the Formula II; with an oxidizing agent and a chiral transition metal complex without using an organic solvent and base wherein said oxidizing agent is used in an amount of about 1.1 to 1.4 molar equivalents relative to said prochiral sulfide of the formula II and the chiral transition metal complex is prepared from a transition metal compound and a chiral ligand; reacting the resultant compound of Formula I to prepare a salt employing an alkali and/or alkaline earth metal source, wherein the R