Patent ID: 6875441
Filing Date: 2005-04-05
Classification: A61K

Abstract:
1. A hematopoictic growth factor delivery composition, the composition comprising: a hematopoictic growth factor capable of stimulating hematopoictic cell activity when administered to a mammalian host; a first biocompatible polymer and a liquid vehicle in which the first biocompatible polymer is at least partially soluble at some temperature, the first biocompatible polymer interacting with the liquid vehicle to impart reverse thermal viscosity behavior to the composition over at least some temperature range, so that the composition is in a lower-viscosity form when the temperature of the composition is at a first temperature within the range and the composition is in a higher-viscosity form when the temperature is at second temperature within the range that is higher than the first temperature; and a second biocompatible polymer being a protective colloid that inhibits the dissolution into aqueous liquids of the first biocompatible polymer at least when the composition is in the higher-viscosity form; wherein the liquid vehicle comprises from 60 weight percent to 96 weight percent of the composition, the first biocompatible polymer comprises from 5 weight percent to 33 weight percent of the composition, and the second biocompatible polymer comprises from 0.1 weight percent to 5 weight percent of the composition: and wherein the hematopietic growth factor comprises G-CSF, the first biocompatible polymer comprises a polyoxyalkylene block copolymer comprising at least one block of a polyoxyethylene and at least one block of a polyoxypropylene, and the second biocompatible polymer comprises a cellulosic polymer.