Patent ID: 6673925
Filing Date: 2004-01-06
Classification: C07D

Abstract:
Method of producing thiobarbituric acid derivatives of formula I whereinR1 is SH, Sâˆ’M+ or CH3Sâ€”, and M+ is an alkali metal ion, by hydrogenolysis of a compound of formula II wherein R2 is chlorine or CH3Oâ€”, witha) a hydrogenolysis agent in the presence of an inert solvent and by a direct reaction of the hydrogenolysis product with an alkali metal methylate in methanol, or b) with a hydrogenolysis agent in the presence of an inert solvent and in the presence of a methylation reagent, and subsequently with an alkali metal methylate in methanol; wherein, hydrogenolysis according to variant a) or b) is carried out at a reaction temperature of 0Â° to 60Â° C.