Patent ID: 6558671
Filing Date: 2003-05-06
Classification: C07K,C12N

Abstract:
An immunogen which comprises a non-naturally occurring, cysteine-depleted CTL epitope which is a cysteine-depleted mutant of a naturally occurring CTL epitope, and which epitope elicits a greater CTL response than said naturally occurring epitope, differing from said naturally occurring epitope in that at least one cysteine residue of the naturally occurring epitope is replaced with a non-cysteine residue, and where said mutant epitope is otherwise either (a) identical to said naturally occurring epitope or (b) differs therefrom solely by (i) a single conservative substitution, and/or (ii) a single non-conservative substitution, wherein at least one of said cysteine-depleted epitopes is an A1-restricted epitope.