Patent ID: 8022102
Filing Date: 2011-09-20
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein: n is an integer, equal to zero, 1, 2, 3, 4, 5 or 6; i, j are integers, independently from each other, equal to zero, 1, 2, 3 or 4; r is an integer, equal to zero, 1, 2 or 3; R R wherein: P is an integer, equal to zero, 1, 2, 3 or 4; q is an integer, equal to 1 or 2; m is an integer, equal to zero, 1, 2 or 3; each R two R wherein R R A and B are, each independently from each other, aryl or an heteroaryl radical selected from the group of; thienyl; pyridinyl; and indolyl; each R R Y is O; X is CR aryl is phenyl, optionally substituted with 1, 2 or 3 substituents independently from each other, selected from the group of halo, hydroxy, alkyloxy and alkyl; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms; each radical optionally substituted with one or more radicals selected from the group of halo, cyano, oxo, hydroxy, formyl, carboxyl and amino; alkenyl is a straight or branched unsaturated hydrocarbon radical having from 4-2 to 6 carbon atoms; or a cyclic unsaturated hydrocarbon radical having from 3 to 6 carbon atoms; each radical optionally substituted with one or more radicals selected from the group of halo, cyano, oxo, hydroxy, formyl, carboxyl or amino radicals; and halo is fluoro, chloro, bromo or iodo.