Patent ID: 9220789
Filing Date: 2015-12-29
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method of making a TNF inhibitor conjugate, said method comprising reacting a TNF inhibitor with a preparation comprising a water-soluble, non-peptidic, and non-nucleotidic polymer backbone having at least one terminus covalently bonded to a structure of formula (1) under conditions suitable for group M or R to react with said TNF inhibitor: or a salt thereof, wherein: A is the point of covalent bonding to the terminus of the polymer backbone; O is oxygen; E is O, wherein O is oxygen; P is phosphorous; K is selected from the group consisting of: alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene; G is selected from the group consisting of: hydrogen, alkoxy, and a hydrophobic separation handle; Z L is an alkylene; M is a protected carboxyl moiety; R is selected from the group consisting of: a protecting group and a hydrophobic separation handle; R wherein no more than one of R, R