Patent ID: 7262192
Filing Date: 2007-08-28
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein R 1 is a cyclic group selected from R A , R B , R C and R D , each of which is optionally substituted with one or more R 7 groups; R 2 is hydrogen or C 1 -C 2 alkyl; R 3 and R 4 are each independently C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl or C 3 -C 10 cycloalkyl, each of which is optionally substituted with one or more R 8 groups, or R E , which is optionally substituted with one or more R 9 groups, or hydrogen; or —NR 3 R 4 forms R F , which is optionally substituted with one or more R 10 groups; R 5 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 7 cycloalkyl, each of which is optionally substituted by one or more groups selected from hydroxy, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 3 -C 7 cycloalkyl and C 3 -C 7 cycloalkoxy, or hydrogen; R 6 is R 6A ; R 6A is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, each of which is optionally substituted by C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy or a cyclic group selected from R J , R K , R L and R M , or R 6A is R N , C 3 -C 7 cycloalkyl or C 3 -C 7 halocycloalkyl, each of which is optionally substituted by C 1 -C 6 alkoxy or C 1 -C 6 haloalkoxy; R 7 is halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 halocycloalkyl, phenyl, OR 12 , OC(O)R 12 , NO 2 , NR 12 R 13 , NR 12 C(O)R 13 , NR 12 CO 2 R 14 , C(O)R 12 , CO 2 R 12 , CONR 12 R 13 or CN; R 8 is halo, phenyl, C 1 -C 6 alkoxyphenyl, OR 12 , OC(O)R 12 , NO 2 , NR 12 R 13 , NR 12 C(O)R 13 , NR 12 CO 2 R 14 , C(O)R 12 , CO 2 R 12 , CONR 12 R 13 , CN, R G or R H , the last two of which are optionally substituted with one or more R 9 groups; R 9 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or CO 2 R 12 ; R 10 is halo, C 3 -C 10 cycloalkyl, C 3 -C 10 halocycloalkyl, phenyl, OR 12 , OC(O)R 12 , NO 2 , NR 12 R 13 , NR 12 C(O)R 13 , NR 12 CO 2 R 14 , C(O)R 12 , CO 2 R 13 , CONR 12 R 13 , CN, oxo, C 1 -C 6 alkyl or C 1 -C 6 haloalkyl, the last two of which are optionally substituted by R 11 ; R 11 is phenyl, NR 12 R 13 or NR 12 CO 2 R 14 ; R 12 and R 13 are each independently hydrogen, C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 14 is C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R A and R J are each independently a C 3 -C 10 cycloalkyl or C 3 -C 10 cycloalkenyl group, each of which may be either monocyclic or, when there are an appropriate number of ring atoms, polycyclic and which may be fused to either (a) a monocyclic aromatic ring selected from a benzene ring and a 5- or 6-membered heteroaromatic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur, or (b) a 5-, 6- or 7-membered heteroalicyclic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur; R B and R K are each independently a phenyl or naphthyl group, each of which may be fused to (a) a C (b) a 5-, 6- or 7-membered heteroalicyclic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur, or (c) a 5- or 6-membered heteroaromatic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur; R C , R L and R N are each independently a monocyclic or, when there are an appropriate number of ring atoms, polycyclic saturated or partly unsaturated ring system containing between 3 and 10 ring atoms, of which at least one is a heteroatom selected from nitrogen, oxygen and sulphur, which ring may be fused to a C 5 -C 7 cycloalkyl or C 5 -C 7 cycloalkenyl group or a monocyclic aromatic ring selected from a benzene ring and a 5- or 6-membered heteroaromatic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur; R D and R M are each independently a 5- or 6-membered heteroaromatic ring containing up to three heteroatoms independently selected from nitrogen, oxygen and sulphur, which ring may further be fused to (a) a second 5- or 6-membered heteroaromatic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur; (b) C (c) a 5-, 6- or 7-membered heteroalicyclic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur; or (d) a benzene ring; R E , R F and R G are each independently a monocyclic or, when there are an appropriate number of ring atoms, polycyclic saturated ring system containing between 3 and 10 ring atoms, of which at least one is a heteroatom selected from nitrogen, oxygen and sulphur; and R H is a 5- or 6-membered heteroaromatic ring containing up to three heteroatoms independently selected from nitrogen, oxygen and sulphur; a tautomer thereof, or a pharmaceutically acceptable salt or polymorph of said compound or tautomer.