Patent ID: 6677333
Filing Date: 2004-01-13
Classification: A61K,C07D

Abstract:
A method for preventing and/or treating diseases induced by poly(ADP-ribose)polymerase, which comprises administering to a subject in need thereof an effective amount of a compound of formula (I) wherein R1 is (i) C1-4 alkyl substituted by hydroxy or amino, or (ii)â€”A1â€”A2â€”A3, in which A1 is (i)â€”NR3C(O)â€”, (ii)â€”NR4C(S)â€”, (iii)â€”NR5SO2â€”, (iv)â€”CH2â€”NR6â€”, (v)â€”CH2â€”Oâ€”, (vi)â€”OC(O)â€”, (vii)â€”CH2â€”NR7C(O)â€”, (viii)â€”NR8C(O)NR9â€”, (ix)â€”NR10C(O)Oâ€”, (x)â€”NR11C(S)NR12, (xi)â€”N(R13)â€”, or with the proviso that the linkage of the right side of each group represented by A1 binds to A2, wherein R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14 and R15 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, A2 is (i) C1-8 alkylene, (ii) C2-8 alkenylene, (iii) Cyc1, (iv)â€”(C1-4 alkylene)â€”Oâ€”(C1-4 alkylene)â€”, (v)â€”(C1-4 alkylene)â€”Sâ€”(C1-4 alkylene)â€”, (vi)â€”(C1-4 alkylene)â€”NR16â€”(C1-4 alkylene)â€”, (vii)â€”(Cyc1)â€”(C1-8 alkylene)â€”, (viii)â€”(C1-8 alkylene)â€”(Cyc1)â€”, or (ix)â€”(C1-4 alkylene)â€”(Cyc1)â€”(C1-4 alkylene), R16 is a hydrogen atom, C1-8 alkyl, C1-8 alkoxycarbonyl, phenyl or C1-8 alkyl substituted by phenyl, Cyc1 is (i) a 3-10 membered mono-cyclic or bi-cyclic carbocyclic ring, or (ii) a 3-10 membered mono-cyclic or bi-cyclic hetero ring having 1-4 nitrogen atoms, 1-2 oxygen atoms and/or one sulfur atom, A3 is (i) a hydrogen atom, (ii)â€”NR17R18, (iii) Cyc2, (iv)â€”OR19, (v)â€”COOR20, (vi)â€”CONR21R22, (vii) Câ‰¡N, (viii) a halogen atom, R17, R21 and R22 each, independently, is (i) a hydrogen atom, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) Cyc3, (vi) C1-8 alkoxy, (vii) C2-8 alkenyloxy, (viii) C2-8 alkynyloxy, or (ix) C1-8 alkyl substituted by Cyc3, C1-8 alkoxy, C1-8 alkylthio, Câ‰¡N, hydroxy or 1-3 of halogen atom, R18 is (i) a hydrogen atom, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) C1-8 alkoxycarbonyl, (vi) C2-8 acyl, (vii) C3-8 cycloalkyl, (viii) C1-8 alkoxycarbonyl substituted by Cyc3 or 1-3 of halogen atom, or (ix) C1-8 alkyl substituted by C1-8 alkoxy, R19 and R20 each, independently, is a hydrogen atom or C1-8 alkyl, R23, R24, R25, R26, R27, R28 and R29 each, independently, is a hydrogen atom, C1-4 alkyl, C1-8 alkoxycarbonyl, phenyl, or C1-4 alkyl substituted by phenyl, Cyc2 is a 3-10 membered mono-cyclic or bi-cyclic hetero ring having 1-4 nitrogen atoms, 1-2 oxygen atoms and/or one sulfur atom, Cyc3 is (i) a 3-10 membered mono-cyclic or bi-cyclic carbocyclic ring, or (ii) a 3-10 membered mono-cyclic or bi-cyclic hetero ring having 1-4 nitrogen atoms, 1-2 oxygen atoms and/or one sulfur atom, the above-mentioned Cyc1, Cyc2 and Cyc3 each, independently, may be optionally substituted by 1-3 of substituents selected from the following (i)-(vii): (i) C1-8 alkyl, (ii) C2-8 alkenyl, (iii) C2-8 alkynyl, (iv) C1-8 alkoxy, (v) C1-8 alkoxycarbonyl, (vi) oxo, and (vii) C1-8 alkyl substituted by C1-8 alkoxy; R2 is a hydrogen atom, a halogen atom, nitro, hydroxy, â€”NR30R31, C1-8 alkyl, C1-8 alkoxy, or C1-8 alkyl or C1-8 alkoxy substituted by 1-3 of halogen atoms, R30 and R31 each, independently, is a hydrogen atom, C1-4 alkyl, C1-8 alkoxycarbonyl, phenyl, C1-4 alkyl substituted by phenyl, with the proviso that, R1 is not dimethylamino, or a non-toxic salt thereof and a carrier.