Patent ID: 7049081
Filing Date: 2006-05-23
Classification: C07K,C12N

Abstract:
1. A method for diagnosing aberrant cellular proliferation associated with a malignant phenotype comprising: a) measuring by radioimmunoassay, competitive-binding assay, Western blot analysis, ELISA assay, or sandwich assay the amount of BTG-2 protein in a sample obtained from a patient, using an antibody that specifically binds the amino acid sequence of SEQ ID NO:2; and b) comparing the amount of BTG-2 protein to a normal control tissue sample, wherein under-expression of the BTG-2 protein in the sample obtained from the patient relative to the normal control tissue sample is diagnostic of aberrant cellular proliferation associated with a malignant phenotype, and wherein said BTG-2 protein consists of the amino acid sequence of SEQ ID NO:2, or a fragment thereof.