Patent ID: 6849735
Filing Date: 2005-02-01
Classification: A61P,C07D

Abstract:
1. A process of synthesizing the 9-substituted hypoxanthine derivative N-4-carboxyphenyl-3-(6-oxopurin-9-yl) propanamide comprising the steps of: (a) forming ethyl 4-(B-alanyl) aminobenzoate by a process including the steps of: (b) reacting aminocyanacetamide with triethyl orthoformate in the presence of acetonitrile to form an imidoester derivative of aminocyanacetamide; (c) reacting the imidoester derivative with ethyl 4-(β-alanyl) aminobenzoate in methanol; (d) forming the six-membered ring of the purine moiety of the hypoxanthine by reacting the ester formed in step (c) with triethyl orthoformate in acetic acid; and (e) hydrolyzing the ester group of the compound formed in step (d) to yield N-4-carboxyphenyl-3-(6-oxopurin-9-yl) propanamide.