Patent ID: 7264937
Filing Date: 2007-09-04
Classification: A61K,A61P,C07D

Abstract:
1. A method for identifying an agonist of HM74 comprising, contacting a potential agonist with a cell expressing HM74 and determining whether in the presence of said potential agonist the signaling activity of HM74 is increased relative to the activity of HM74 in the absence of said potential agonist, wherein said potential agonist has the structure: where X is O, NR R R2 is an R1 group, a (C1-C10) alkyl-(C3-C10) cycloalkyl, which may be branched, may contain a heteroatom or may be substituted, or combinations thereof; or X and R2 may form a ring; R3 is H or R1; and Y is carbonyl, a Schiff base, an oxine, a ketal, an acetal, an oxazolidine, a thiazolidine or an enol ester.