Patent ID: 6403769
Filing Date: 2002-06-11
Classification: A61K,C07K

Abstract:
A fusion protein, comprising (A) an IgG sequence, (B) a nonantibody sequence covalently joined to the aminoterminal end of said IgG sequence and (C) a heterologous signal peptide that is covalently joined to the aminoterminal of said nonantibody sequence, wherein(i) said IgG sequence consists of a hinge region, a CH2 domain and a CH3 domain, in that order, said IgG sequence lacking a CH1 domain, (ii) said nonantibody sequence comprises an effector domain of a molecule selected from the group consisting of PDGF B, KGF, KGFR and &bgr; PDGFR, (iii) said heterologous signal peptide is a signal peptide of PDGF A.