Patent ID: 8987225
Filing Date: 2015-03-24
Classification: A61K,A61P,C07H,C12N,Y10T

Abstract:
1. A method of upregulating a function of and/or the expression of an NANOG polynucleotide having SEQ ID NO: 1 in a mammalian system comprising: contacting said system with at least one antisense oligonucleotide 10 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 90% sequence identity to a 14 to 30 nucleotide region of a reverse complement of a natural antisense polynucleotide of an NANOG polynucleotide and specifically binds to said natural antisense polynucleotide; thereby upregulating a function of and/or the expression of the NANOG polynucleotide.