Patent ID: 6503184
Filing Date: 2003-01-07
Classification: A61K,C07K

Abstract:
A method of inhibiting binding of Endokine-alpha to endogenous Endokine-alpha receptors in a mammal comprising administering to said mammal an effective amount of TR11 polypeptide selected from the group consisting of:(a) a polypeptide whose amino acid sequence comprises amino acid residues âˆ’25-137 of SEQ ID NO:2; (b) a polypeptide whose amino acid sequence comprises amino acid residues 1-137 of SEQ ID NO:2; (c) a polypeptide whose amino acid sequence comprises amino acid residues 1-114 SEQ ID NO:2; and (d) a polypeptide fragment of the polypeptide of SEQ ID NO:2, wherein said fragment binds endokine-alpha; in a pharmaceutically acceptable carrier.