Patent ID: 6025345
Filing Date: 2000-02-15
Classification: A61K,C07F

Abstract:
A compound of the formula: ##STR47## wherein R.sub.1 is hydrogen, hydroxy, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl group, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.1 ;R.sub.2 is C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl group, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.1, wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl group is substituted with carboxylic acid;R.sub.3 and R.sub.4 are independently hydrogen, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, dialkyl, halogen, or Ar.sub.1 provided that both R.sub.3 and R.sub.4 are not hydrogen,wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl groups of R.sub.1 and R.sub.2 may be optionally substituted with C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 or C.sub.5 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, halo, hydroxy, carboxy, nitro, trifluoromethyl, C.sub.1 -C.sub.6 straight or branched chain alkyl, C.sub.2 -C.sub.6 straight or branched chain alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy, phenoxy, benzyloxy, or Ar.sub.1, and where Ar.sub.1 is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2-indolyl, 3-indolyl, 4-indolyl, 2-furyl, 3-furyl, tetrahydrofuranyl, 2-thienyl, 3-thienyl, 4-thienyl, 2-, 3-, or 4-pyridyl, or phenyl, having one to five substituents which are independently selected from the group consisting of hydrogen, halo, hydroxy, carboxy, nitro, trifluoromethyl, C.sub.1 -C.sub.6 straight or branched alkyl, C.sub.2 -C.sub.6 straight or branched alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy, phenoxy, and benzyloxy; or a pharmaceutically acceptable salt, hydrate, or a mixture thereof; provided that at least one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is not a heterocycle.