Patent ID: 6667412
Filing Date: 2003-12-23
Classification: C07C,C07D

Abstract:
A nitrile compound represented by the following formula (I): whereinR1s are the same as or different from each other and each means hydrogen atom, a halogen atom, hydroxyl group, a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, a lower alkoxyalkoxy group, a halogenated lower alkyl group, a hydroxy-lower alkyl group, a cyano-lower alkyl group, a halogenated lower alkoxy group, a hydroxy-lower alkoxy group, a cyano-lower alkoxy group, a lower acyl group, nitro group, an optionally substituted amino group, an optionally substituted carbamoyl group, an optionally substituted sulfamoyl group, mercapto group or a lower alkylthio group; R2 means a lower alkyl group or a lower cycloalkyl group, and two R1s may combine to form an aliphatic ring, an aromatic ring, a hetero ring or an alkylenedioxy ring; n means 0 or an integer of from 1 to 5; m means an integer of from 1 to 6; and R3 means carboxyl group, a lower alkoxycarbonyl group, a phenyloxycarbonyl group optionally having a substituent, a phenyl-lower alkylenyl group optionally having a substituent, or hydroxymethyl group; with the proviso that the following nitrile compounds are excluded:wherein R1 is a halogen, R2 is a lower alkyl, n is 0 or 1 and R3 is a phenyl-lower alkylenyl optionally having a substituent; wherein R1 is a lower alkyl, a lower alkoxy, hydrogen atom, a halogen atom, a halogenated lower alkyl, or two R1's form an alkylenedioxy ring, R2 is isopropyl, R3 is a carboxyl or hydroxymethyl, m is 2 and n is an integer of 1 to 3; wherein R1 is hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy, R2 is methyl, m is 1, n is 0, 1 or 2; wherein R1 is hydroxy or mercapto, n is 1, R2 is lower alkyl, R3 is a phenyl-(1-4C)alkyl; wherein R1 is hydrogen atom, nitro, a lower alkoxy, or an amino optionally having a substituent, or two R1's form an alkylenedioxy ring, R2 is a lower alkyl, R3 is a carboxyl or a lower alkoxycarbonyl, m is 2 and n=1; and wherein R1 is a lower alkoxy, hydroxyl, a halogen atom, a halogenated lower alkyl, a lower alkylthio, a carbamoyl optionally having a substituent or an amino optionally having a substituent, R2 is a lower alkyl, R3 is a carboxylic acid, m is 2, and n is 1, 2 or 3.