Patent ID: 6403603
Filing Date: 2002-06-11
Classification: A61P,C07D

Abstract:
A process for preparing a 9-amino camptothecin of formula (I) said process comprising the steps of:(1) reducing the compound of formula (II) to form a compound of formula (III) (2) converting the compound of formula (III) into a compound of formula (IV) â€ƒwherein X is a halogen; (3) nitrating the compound of formula (IV) to form a compound of formula (V) â€ƒwherein X is as defined above; and (4) reducing in a single step the compound of formula (V), to form the 9-amino camptothecin of formula (I) or, alternatively, (5) reducing the compound of formula (V), to form a compound of formula (VI) â€ƒwherein X is as defined above, and (6) removing the X group by reducing the compound of formula (VI), to form the 9-amino camptothecin of formula (I).