Patent ID: 9090701
Filing Date: 2015-07-28
Classification: A61P,C07K,G01N

Abstract:
1. A method of detecting oxidized calcium/calmodulin-dependent protein kinase II (oxCaMKII), the method comprising: (a) contacting a biological sample from a patient with a composition comprising a purified monoclonal antibody or antigen-binding fragment thereof that binds specifically to oxCaMKII to form a complex, wherein the monoclonal antibody or antigen-binding fragment binds specifically to oxCaMKII delta having an amino acid sequence comprising SEQ ID NO:12 and having oxidized methionine residues at positions 281 and 282, and wherein the monoclonal antibody or antigen-binding fragment does not bind to CaMKII delta having an amino acid sequence comprising SEQ ID NO:12 and having non-oxidized methionine residues at positions 281 and 282; and (b) detecting the complex.