Patent ID: 6552200
Filing Date: 2003-04-22
Classification: A61P,C07C,C07D

Abstract:
A process for preparing a compound of the formula wherein W represents â€”C(&boxH;O)â€” or â€”CH(OH)â€”; R1 represents hydrogen or hydroxy; R2 represents hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is â€”COOH or â€”COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0, comprising converting into said compound an intermediate compound of the formula whereinA is a hydrogen or hydroxy; and R5 is H, OH, Br, Cl, I, CN or â€”CONR6R7 wherein R6 and R7 are each independently H, C1-C6alkyl, C1-C6alkoxy or R6 and R7 taken together with the nitrogen atom form a pyrrolidone, piperidine or morpholine, with the proviso that R6 and R7 cannot both be represented by C1-C6alkoxy or by C1-C6 alkyl.