Patent ID: 7291498
Filing Date: 2007-11-06
Classification: A61P,C07K,C12N

Abstract:
1. A method of producing a chimeric adenovirus in a selected host cell type, said chimeric adenovirus derived from a parental adenovirus which is not useful for adenovirus virion production in the host cell type, said method comprising the steps of: (a) generating a chimeric adenovirus comprising: b) producing said chimeric adenovirus in the presence of functional adenovirus E1a, E1b, and E4 ORF6 genes from the first adenovirus or from an adenovirus serotype which transcomplements the first adenovirus, and further in the presence of necessary adenoviral structural genes from the left end of the first adenovirus or from an adenovirus serotype which transcomplements the first adenovirus.