Patent ID: 8367384
Filing Date: 2013-02-05
Classification: A61F,A61K,A61L,A61P,B33Y,C12N

Abstract:
1. A method of making a device, comprising: receiving an implantable porous bone structure that includes an internal cavity therein and a plurality of pores that are in communication with the internal cavity; wherein the implantable porous bone structure includes at least one of organic, anorganic, demineralized or freeze-dried bone; receiving a semi-permeable membrane separately formed from the implantable porous bone structure prior to combining the implantable porous bone structure and the semi-permeable membrane, wherein the semi-permeable membrane is substantially continuous and capable of covering multiple ones of the plurality of pores of the implantable porous bone structure; and combining the implantable porous bone structure and the semi-permeable membrane wherein the semi-permeable membrane covers the multiple ones of the plurality of pores of the implantable porous bone structure, the semi-permeable membrane positioned and configured to allow one or more biologically active substances disposed in the internal cavity to pass through the semi-permeable membrane and out of the implantable porous bone structure while the semi-permeable membrane covers the at least a portion of the plurality of pores of the implantable porous bone structure.