Patent ID: 8815859
Filing Date: 2014-08-26
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein: R1 is ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, octyl, decanyl, dodecanyl, hexadecyl, octadecyl, ethenyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-pentenyl, 3-pentenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, or alkoxyalkyl, each unsubstituted; R2 is hydrogen; R3 is hydrogen; A is aryl, heteroaryl, or arylalkyl, wherein alkyl, aryl and heteroaryl groups can be optionally substituted by one or more substituents Y; Y is hydroxy, thio, halogen, cyano, trifluoromethoxy, trifluoromethyl, carboxy, carboxymethyl, carboxyethyl, alkyl, alkoxy, alkylamino, aryl, aryl sulfonylalkyl, aryloxy, arylalkoxy, NR5R6, azido, nitro, guanidino, amidino, phosphono, oxo, carbamoyl, alkylsulfonyl, alkylsulfinyl, alkylthio or SF R5 and R6 together can constitute a heterocycle; or R2 and R3 can constitute a cycle which corresponds to formula (II) wherein: R1 and A are defined as above; n is 4 R4 represents one or more hydrogen, alkyl, alkoxy, cycloalkyl, aryl, wherein alkyl, cycloalkyl and aryl groups can be optionally substituted by one or more hydroxy, halogen, alkyl, alkoxy, trifluoromethoxy, trifluoromethyl, alkylsulfonyl, or NR7R8; and R7 and R8 are independently hydrogen, alkyl, or cycloalkyl; or racemic forms, tautomers, enantiomers, diastereomers, epimers, or mixtures thereof, or pharmaceutically acceptable salts thereof.