Patent ID: 7884227
Filing Date: 2011-02-08
Classification: C07C,Y10T

Abstract:
1. A method of synthesizing felbamate, comprising the steps of: (a) adding a solution of 2-phenyl-1,3-propanediol to a solution of chlorosulfonyl isocyanate while maintaining a temperature at less than about −20° C. over a first period ranging from about 10 minutes to about 60 minutes; (b) maintaining temperature of the solution of 2-phenyl-1,3-propanediol and chlorosulfonyl isocyanate at less than about −20° C. for a second period ranging from about 30 minutes to about 45 minutes while stirring; (c) adding water to the solution of 2-phenyl-1,3-propanediol and chlorosulfonyl isocyanate and increasing the temperature to a range of about 20° C. to about 40° C.; (d) concentrating the solution of 2-phenyl-1,3-propanediol and chlorosulfonyl isocyanate after step (c); (e) adding water to the solution of 2-phenyl-1,3-propanediol and chlorosulfonyl isocyanate after step (d) and cooling to about 5° C. to 30° C.; and (f) isolating felbamate which precipitates from the solution of 2-phenyl-1,3-propanediol and chlorosulfonyl isocyanate.