Patent ID: 6867004
Filing Date: 2005-03-15
Classification: B82Y,C07K,G01N

Abstract:
1. A method of testing an antibody to a fungus in a sample, the method comprising: a) producing a fungal antigen suitable for testing an antibody to a fungus, comprising providing a fungal antigen as a culture filtrate, the fungal antigen having not been purified by ion exchange chromatography or isoelectric focusing from the culture filtrate, and contacting the fungal antigen with an oxidizing agent to produce an oxidized fungal antigen suitable for testing an antibody to the fungus; b) contacting a sample suspected of containing an antibody to a fungus with the oxidized fungal antigen produced in step a) under suitable conditions to allow binding of the antibody, if present in the sample, to the oxidized fungal antigen; and c) assessing binding between the antibody and the oxidized fungal antigen to determine the presence and/or amount of the antibody in the sample.