Patent ID: 8481569
Filing Date: 2013-07-09
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula: wherein ring A- is an aromatic ring group having at least one substituent R R (1) a group represented by the formula —S(O) (2) a non-aromatic nitrogen-containing heterocyclic group optionally having substituent(s), (3) a carbamoyl group optionally having substituent(s), (4) an amino group substituted by carbamoyl optionally having substituent(s), (5) an alkoxycarbonyl group, and (6) an alkyl group substituted by hydroxy, and R provided that 5-chloro- 1-{4-[(dimethylamino)sulfonyl]benzyl}-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-1-[3-(1-hydroxy-1-methylethyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide, methyl3-{[3-(aminocarbonyl)-5 -chloro-2-iminopyridin-1 (2H)-yl]methyl}benzoate, 1-[3-(aminocarbonyl)benzyl]-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-1-[4-chloro-2-(methylsulfonyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-2-imino-1-[4-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide, 5-chloro-2-imino-1-[2-methoxy-5-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide, 5-chloro-1-[2-chloro-4-(methylsulfonyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-1-{3-chloro-5-[(methylamino)carbonyl]benzyl}-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-1-[2-chloro-5-(methylsulfonyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide, 1-[3-(aminocarbonyl)-5-chlorobenzyl]-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide, 5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide, and 5-chloro-2-imino-1-(3-morpholin-4-ylbenzyl)-1,2-dihydropyridine-3-carboxamide are excluded, or a salt thereof.