Patent ID: 7405331
Filing Date: 2008-07-29
Classification: C07B,C07C

Abstract:
1. A process for producing a (fluoroalkyl)benzene derivative comprising: a step of reducing a total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less on atomic basis, said alkylbenzene derivative being represented by the formula (1): wherein X 1 is hydrogen, hydroxyl, alkyl, aryl, halogen inclusive of fluorine, formyl, carboxyl, nitro, cyano, amino, hydroxymethyl, aminomethyl, carbamoyl, sulfonic acid group or halogenocarbonyl inclusive of fluorocarbonyl, or X 1 is alkyloxycarbonyl, alkylcarbonyl, arylcarbonyl, alkyloxy or aryloxy, each being optionally substituted; R 1 is carboxyl, halogenocarbonyl inclusive of fluorocarbonyl, alkyloxycarbonyl, aryloxycarbonyl, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl; n is an integer of 1 to 5 with the proviso that when n is 2 to 5, a plurality of R 1 groups may be the same or different, but at least one of R 1 is alkyl; a step of halogenating said at least one alkyl group of the purified alkylbenzene derivative by a photohalogenation using a halogen other than fluorine to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or more per one mole of the (haloalkyl)benzene derivative, thereby producing said high-purity (fluoroalkyl)benzene derivative represented by the formula (2): wherein X 2 corresponds to X 1 of the formula (1) and is hydrogen, hydroxyl, fluoroalkyl, aryl, halogen inclusive of fluorine, formyl, fluorocarbonyl, nitro, cyano, amino, hydroxyfluoromethyl, aminofluoromethyl, carbamoyl or sulfonylfluoride, or X 1 is fluoroalkyloxycarbonyl, fluoroalkylcarbonyl, arylcarbonyl, fluoroalkyloxy or aryloxy, each being optionally substituted; R 2 corresponds to R 1 of the formula (1) and is fluorocarbonyl, fluoroalkyloxycarbonyl, aryloxycarbonyl, substituted or unsubstituted fluoroalkyl, or substituted or unsubstituted aryl; n is an integer of 1 to 5 with the proviso that when n is 2 to 5, a plurality of R 2 groups may be the same or different, but at least one of R 2 is fluoroalkyl.