Patent ID: 8629241
Filing Date: 2014-01-14
Classification: A61K,A61P,C07K

Abstract:
1. A compound having the formula (I): wherein each Xaa is independently selected from any L-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation; or wherein each Xaa is independently selected from any D-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation; wherein the amino acid residues that are favorable to alpha helix formation are selected from alanine, arginine, lysine, methionine, leucine, glutamic acid, glutamine, cysteine, isoleucine, phenylalanine, tryptophan, histidine and aspartic acid; wherein the compound has at least three (1,5) intramolecular hydrogen bonds; R R each R L is selected from —NH—C(O)—, —C(O)—NH—, —S—S—, —CH(OH)CH m is 4; n is 1; and t is 0, 1 or 2.