Patent ID: 6387404
Filing Date: 2002-05-14
Classification: A61K,A61P

Abstract:
A sustained release tablet for oral administration, comprisingan immediate release tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml, said tablet core containing a sufficient amount of said therapeutically active agent to render a therapeutic effect; a second therapeutically active agent in a sufficient amount to render a therapeutic effect, said second therapeutically active agent being relatively soluble in water compared to said insoluble therapeutically active agent and being selected from the group consisting of antihistamines, analgesics, anti-inflammatory agents, gastro-intestinals, anti-emetics, anti-epileptics, vasodilators, anti-tussive agents, expectorants, anti-asthmatics, anti-spasmodics, hormones, diuretics, anti-hypertensives, bronchodilators, anti-inflammatory steroids, antivirals, antibiotics, antihemorrhoidals, hypnotics, psychotropics, antidiarrheals, mucolytics, sedatives, decongestants, laxatives, antacids, vitamins, and stimulants; and, a film coating formed over said core, said film coating comprising a sufficient amount of a hydrophobic material to provide a sustained release of said therapeutically active agent when said coated tablet is exposed to aqueous solutions.