Patent ID: 6469048
Filing Date: 2002-10-22
Classification: A61K,C07D,Y02A

Abstract:
A method for treating cancer in a mammal, comprising administering to a mammal a therapeutically effective amount of an &agr;-pyrone, such that treatment of cancer in the mammal occurs, wherein said &agr;-pyrone is of the formula: whereinX is O or S; R1 or R2 are each independently a hydrogen atom, substituted or unsubstituted alkyl ester group, alkenyl ester group or alkynyl ester group; R3 is a sugar moiety; and pharmaceutically acceptable salts or esters thereof, wherein each substituent on R1 or R2 are each independently halogen, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkythiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino, alkyl amino, dialkylamino, arylamino, diarylamino, alkylarylamino, acylamino, alkylcarbonylamino, arylcarbonylamino, carbamoyl, ureido, amidino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, azido, heterocyclyl, alkylaryl, aromatic or heteroaromatic moieties.