Patent ID: 8658149
Filing Date: 2014-02-25
Classification: A61K,A61P,C07F,C07K

Abstract:
1. A conjugate comprising a polymeric backbone having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting moiety, the conjugate having the general Formula: wherein: x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; B is said anti-angiogenesis agent; D is said bisphosphonate bone targeting moiety; and L the conjugate further comprising a spacer linking said anti-angiogenesis agent to said linker or to said polymeric backbone, said spacer being such that facilitates attachment of said anti-angiogensis agent to said polymeric backbone, and is being a degradable spacer that undergoes a spontaneous degradation once it is cleaved from the polymeric conjugate.