Patent ID: 6287787
Filing Date: 2001-09-11
Classification: C07K,C40B,G01N

Abstract:
A dimeric oligopeptide mixture set comprised of dimer molecules having two bonded portions in which the oligopeptide chains of a first oligopeptide portion are bonded by a disulfide bond to the oligopeptide chains of a second oligopeptide mixture portion, wherein(A) each oligopeptide in said first oligopeptide portion has(a) a chain that contains the same number of 3 to about 10 amino acid residues, including an oxidized mercaptan-containing residue that is located at the same position in each oligopeptide chain and forms part of said disulfide bond, said oxidized mercaptan-containing residue being the only mercaptan-containing residue in the chain,(b) an amino acid residue sequence, in addition to said oxidized mercaptan-containing residue, that contains one of at least six predetermined amino acid residues at the same, one or more predetermined positions of the oligopeptide chain; and(B) each oligopeptide in said second oligopeptide mixture portion bonded to said first oligopeptide portion has(a) a chain that contains the same number of 3 to about 10 amino acid residues, including an oxidized mercaptan-containing residue that is located at the same position in each oligopeptide chain and forms a part of said disulfide bond, said oxidized mercaptan-containing residue being the only mercaptan-containing residue present in the chain, andsaid second oligopeptide mixture having equimolar amounts of said at least six different amino acid residues at the same one or more other positions of the oligopeptide chain;said dimeric oligopeptide mixture set being substantially free of oligopeptide molecules having no disulfide bond.