Patent ID: 7019161
Filing Date: 2006-03-28
Classification: C07B,C07C

Abstract:
1. A process for the preparation of optically active compounds of the formula IA or IB as free bases or as acid addition salts thereof, in which R R R R which process comprises (a) hydrogenating a compound of the formula II in which R R in which the radicals R 1 and R 6 are as defined for compounds of the formula II and the radicals R 2 , R 3 , R 4 and R 5 are as defined for compounds of the formulae IA and IB; (b) then converting the product obtained with an acid of the formula [H in which n is 1, X n− is an acid anion, R 1 and R 6 are as defined for compounds of the formula II, and R 2 , R 3 , R 4 and R 5 are as defined for compounds of the formulae IA and IB; which is (c) converted by removal of the chiral auxiliary group R in which n and the radicals R 2 to R 5 and X n− are as defined above, and, optionally, (d) the acid addition salt of the formula IVA or IVB obtained is converted in the presence of a base into the free compounds of the formula IA or IB; and/or, optionally, the group R