Patent ID: 7270827
Filing Date: 2007-09-18
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A composition comprising a pharmaceutically acceptable carrier and a mixture of at least two hybrid polypeptides selected from (a) a hybrid polypeptide consisting of six different immunogenic amino terminal peptides from six different group A streptococcal M proteins M24, M5, M6, M19, M29 and M14, wherein the six different immunogenic amino terminal peptides are linked in tandem by at least two amino acids, wherein each of the immunogenic amino terminal peptides comprises at least 30 contiguous amino acids of each of said group A streptococcal M proteins, wherein the immunogenic amino terminal peptide at the amino terminus of the hybrid polypeptide is reiterated at the carboxy terminus of the hybrid polypeptide and wherein the hybrid polypeptide is capable of eliciting an immune response against more than one of said group A streptococcal M proteins M5, M6, M14, M19, M24 and M29; (b) a hybrid polypeptide consisting of seven different immunogenic amino terminal peptides from seven different group A streptococcal M proteins M2, M43, M94, M22, M11, M59 and M33, wherein the seven different immunogenic amino terminal peptides are linked in tandem by at least two amino acids, wherein each of the immunogenic amino terminal peptides comprises at least 35 contiguous amino acids of each of said group A streptococcal M proteins, wherein the immunogenic amino terminal peptide at the amino terminus of the hybrid polypeptide is reiterated at the carboxy terminus of the hybrid polypeptide and wherein the hybrid polypeptide is capable of eliciting an immune response against more than one of said group A streptococcal M proteins M2, M11, M22, M33, M43, M59 and M94; (c) a hybrid polypeptide consisting of seven different immunogenic amino terminal peptides from seven different group A streptococcal M proteins M89, M101, M77, M114, M75, M76 and M92, wherein the seven different immunogenic amino terminal peptides are linked in tandem by at least two amino acids, wherein each of the immunogenic amino terminal peptides comprises at least 40 contiguous amino acids of each of said group A streptococcal M proteins, wherein the immunogenic amino terminal peptide at the amino terminus of the hybrid polypeptide is reiterated at the carboxy terminus of the hybrid polypeptide and wherein the hybrid polypeptide is capable of eliciting an immune response against more than one of said group A streptococcal M proteins M75, M76, M77, M89, M92, M101 and M114; and (d) a hybrid polypeptide consisting of seven different immunogenic amino terminal peptides from seven different group A streptococcal proteins M1.0, M12, Spa, M28, M3, M1.2, M18 and M1.0, wherein the seven different immunogenic amino terminal peptides are linked in tandem by at least two amino acids, wherein each of the immunogenic amino terminal peptides comprises at least 50 contiguous amino acids of each of said group A streptococcal proteins, wherein the immunogenic amino terminal peptide at the amino terminus of the hybrid polypeptide is reiterated at the carboxy terminus of the hybrid polypeptide and wherein the hybrid polypeptide is capable of eliciting an immune response against more than one of said group A streptococcal proteins Spa, M1.0, M1.2, M3, M12, M18 and M28.