Patent ID: 7041666
Filing Date: 2006-05-09
Classification: A61P,C07D

Abstract:
1. A compound having the structural formula I or a pharmaceutically acceptable salt thereof; wherein: R is selected from the group consisting of R —CH═C(CH 3 ) 2 , and —CH═CH—CH 3 ; R R R R R R —O—CH R R R R R R R R R R R Q and Q m and n are each independently 1-3; p and q are each independently 0-2; s is 0-4; W is aryl pyridyl or thienyl, and wherein said aryl, pyridyl or thienyl is optionally substituted with 1-3 substituents, which can be the same or different, and are independently selected from the group consisting of alkyl,aryl, alkylcycloalkyl, halo, hydroxy, hydroxyalkyl, alkoxy, alkylalkoxy, alkoxyalkoxy, —NR X is selected from the group consisting of H, NH X is —R Y is selected from the group consisting of —N(R Z is selected from the group consisting of H, alkyl, alkoxyalkyl, R 8 -aryl-, R 8 -aryl(C 1 -C 6 )alkyl-, R 8 -heteroaryl-, R 8 -bicyclicalkyl-, aminoalkyl, alkylamino, NH 2 , —N—(R 6 )(CH 2 ) s -aryl, —N(R 6 )(CH 2 ) s -heteroaryl, —N(R 6 )C(O)OR 17 , alkylcycloheteroalkyl, cycloheteroalkyl, cycloheteroalkylalkyl, alkoxycycloheteroalkyl, heteroaryl; R 8 -benzofused heteroaryl-, diphenylmethyl and R 9 —C(O)—; or when Y is Z can also be —OH, R 9 —SO 2 —, R 17 —N(R 11 )(CH 2 ) s —C(O)—, R 17 —OC(O)—, R 17 —O(CH 2 ) n C(O)—, benzofused heteroaryl(CH 2 ) n C(O)—, benzofused heteroaryl(CH 2 ) n — or R 17 —N(R 11 )—C(S)—; or when Q is Z can also be R 17 R 11 N—, phenylamino or pyridylamino; or Z and Y taken together are selected from the group consisting of