Patent ID: 8333995
Filing Date: 2012-12-18
Classification: A61K,A61P,C07K

Abstract:
1. A process of preparing microparticles comprising (a) combining an antibody and a phase separating enhancing agent (PSEA) that is water-soluble or soluble in a water-miscible solvent in an aqueous solution to form a single continuous liquid phase and to provide a substantially amorphous antibody composition, and (b) cooling the composition to a temperature below phase transition temperature of the composition such that microparticles are formed after the composition is at or below the phase transition temperature of the composition and said PSEA remains in a liquid phase, wherein said antibody is at least about 20% of said microparticles by weight and microparticles are formed upon cooling the composition and said microparticles are readily soluble upon injection in a physiological environment.