Patent ID: 6638937
Filing Date: 2003-10-28
Classification: C07D

Abstract:
A compound of the following formula I, enantiomers, diastereomers, salts and solvates thereof: wherein: R2 is hydrogen, halogen, â€”CHO, alkyl, haloalkyl, (cycloalkyl)alkyl, alkenyl, alkynyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, aryloxy alkoxyalkoxy, cyano, hydroxy, hydroxyalkyl, nitro, â€”CH(OR13)(OR14), â€”(CH2)wY; R3 is heteroaryl; R4 and R5 are each independently alkyl, hydroxyalkyl, cycloalkyl, hydroxy substituted cycloalkyl, alkoxyalkyl, or hydroxy substituted alkoxyalkyl, or R4 and R5 together form a cyclobutyl, cyclopentyl, cyclohexyl, tetrahydrofuranyl or tetrahydropyranyl ring which may be optionally substituted with one or more hydroxy groups; R6 is alkyl, hydroxyalkyl, haloalkyl, hydroxy substituted haloalkyl, cycloalkyl, hydroxy substituted cycloalkyl, (cycloalkyl)alkyl, hydroxy substituted (cycloalkyl)alkyl, aralkyl, alkoxy, hydroxy substituted alkoxy, alkoxyalkyl, hydroxy substituted alkoxyalkyl, or â€”NR16R17; R13 and R14 are alkyl or together form a five to six-membered ring; R16 and R17 are independently hydrogen, alkyl, hydroxyalkyl, cycloalkyl, (cycloalkyl)alkyl, alkoxyalkyl, aralkyl, heterocycloalkyl, aryl, heteroaryl or â€”(CH2)wQ, or R16 and R17 may together form a four to six-membered heterocyclic ring; w is 0, 1, or 2; Y is heteroaryl, â€”COOH, â€”COOR18, â€”CONR19R20, â€”NR19R20, â€”NR19â€”OR20, â€”NR21(C&boxH;O)R22, â€”NR21(C&boxH;O)NR19R20, â€”N(R19)-(alk)â€”NR21(C&boxH;O)R22, â€”NR21(C&boxH;O)OR18, â€”NR21SO2R22, â€”SO2R22, Q, R or S; R18, R19, R20, R21 and R22 are each independently hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, or R19 and R20 may together form a four to seven-membered heterocyclic ring; R23 and R24 are each independently hydrogen, alkyl or cycloalkyl, or may together form a three to seven membered cycloalkyl ring; Z is oxygen, x is 2, 3 or 4; R25, R26 and R27 are each independently hydrogen, alkyl or cycloalkyl, or R26 and R27 may together form a three to seven-membered cycloalkyl ring; R101, R102, R103, and R104 are each independently hydrogen, halogen, â€”CHO, alkyl, haloalkyl, (cycloalkyl)alkyl, alkenyl, alkynyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, alkoxyalkoxy, cyano, hydroxy, hydroxyalkyl, nitro, â€”CH(OR13)(OR14), or â€”(CH2)wY; wherein said rings; aryl alone or as part of another group; or heteroaryl alone or as part of another group may each optionally be substituted by one or more hydrogen, halogen, cyano, alkyl, hydroxyalkyl, alkoxy, nitro or trifluoromethyl groups; provided that said compound is other than