Patent ID: 6844354
Filing Date: 2005-01-18
Classification: A61K,A61P

Abstract:
1. A method for treatment of interstitial pneumonia and pulmonary fibrosis, which comprises administering an effective amount of a compound having a Rho kinase inhibitory activity to a patient, wherein the compound having a Rho kinase inhibitory activity is an amide compound of the following formula (I), wherein Ra is a group of the formula in the formulas (a) and (b), R is hydrogen, alkyl, or cycloalkyl, cycloalkylalkyl, phenyl or aralkyl, which optionally has a substituent on the ring, or a group of the formula  wherein R R R R A is a group of the formula  wherein R in the formula (c), L is hydrogen, alkyl, aminoalkyl, mono- or dialkylaminoalkyl, tetrahydrofurfuryl, carbamoylalkyl, phthalimidoalkyl, amidino or a group of the formula  wherein B is hydrogen, alkyl, alkoxy, aralkyl, aralkyloxy, aminoalkyl, hydroxyalkyl, alkanoyloxy-alkyl, alkoxycarbonylalkyl, α-aminobenzyl, furyl, pyridyl, phenyl, phenylamino, styryl or imidazopyridyl, in the formula (c), a broken line is a single bond or a double bond, and R Rb is a hydrogen, an alkyl, an aralkyl, an aminoalkyl or a mono- or dialkylaminoalkyl; and Rc is an optionally substituted heterocycle containing nitrogen, an isomer thereof and/or a pharmaceutically acceptable acid addition salt thereof.