Patent ID: 6239134
Filing Date: 2001-05-29
Classification: A61P,C07D

Abstract:
A compound of the formula (1): ##STR9##wherein:two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen;R is H, halogen, OH, SH, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 thioalkyl, phenoxy, thiophenoxy, or phenyl, the phenyl ring being optionally substituted by from one to three substituents selected from C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 alkoxy; CF.sub.3 ; Cl; Br; F; CN; or;A is N;R.sub.1 is aryl, thiazole, thiophene, 2-pyridyl, 3-pyridyl, 4-pyridyl, benothiophene, indole or cycloalkyl groups, the aryl, thiazole, thiophene, 2-pyridyl, 3-pyridyl, 4-pyridyl, benzothiophene, indole or cycloalkyl groups being optionally substituted by from 1 to 3 substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy; CF.sub.3, Cl, Br, F, CN, or CO.sub.2 CH.sub.3 ;R.sub.2 is H or C.sub.1 -C.sub.6 alkylR.sub.3 is C.sub.1 -C.sub.6 alkyl, aryl, thiazole, thiophene, 2-pyridyl, 3-pyridyl, 4-pyridyl, indole or C.sub.3 to C.sub.8 cycloalkyl optionally substituted by C.sub.1 -C.sub.6 alkyl, the aryl, thiazole, thiophene, 2-pyridyl, 3-pyridyl, 4-pvridyl, or indole groups being optionally substituted by from one to three substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, CF.sub.3, Cl, Br, F, CN, or CO.sub.2 CH.sub.3 ;or a pharmaceutically acceptable salt thereof.