Patent ID: 6242617
Filing Date: 2001-06-05
Classification: B01D,C07D

Abstract:
A method of production of lyophilized hydrochloride 1.beta., 10.beta.-epoxy-13-dimethyl amino-guaia-3(4)-en-6, 12-olide from endemic plant Artemsia glabella Kar. et Kir. including resin extraction from the initial product, its purification from worthless substances, said resin separation into separate components by the method of column chromatography with production of technical arglabin which is further subjected to recrystallisation, amination and hydrochloration with production of aminoarglabin hydrochloride and its further recrystallisation, drying, lyophilisation and high qualitative identification in which:said amination is carried out by solving crystalline arglabin in alcohol with addition of dimethylamine to the said solution till pH of said solution reaches 12.3-12.4, at the previous stage to extract aminoarglabin hydrochloride containing aminoarglabin, alcohol is distilled and chloroform is filled in, the remaining water is removed, said solution is filtered, said chloroform is evapored and alcohol added, the said solution is barbotaged by chlorine till pH of the solution reaches 5.0-5.5, said alcohol is evapored and ethylacetate is added.