Patent ID: 9161938
Filing Date: 2015-10-20
Classification: A61K,A61L,A61P,C08L,Y02A

Abstract:
1. A method of reducing ocular occlusion in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient in need thereof to provide a therapeutically effective amount of a brimonidine freebase to the patient for at least about one week, wherein said implant comprises brimonidine freebase associated with a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the brimonidine freebase from the implant for a time effective to reduce ocular vascular occlusion in an eye in which the implant is placed, the time being at least about one week after the implant is placed in the eye and wherein said polymer matrix comprises two different polylactide polymers in a 1:1 ratio wherein said first polylactide polymer has a molecular weight of 63.3 kD and said second polylactide polymer has a molecular weight of about 14 kD, and wherein the method is effective in reducing ocular occlusion in the eye of the patient.