Patent ID: 6787539
Filing Date: 2004-09-07
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinR1 is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, â€”S-lower alkyl, â€”S(O)2-lower alkyl, â€”N(Ra)â€”(CH2)nâ€”N(Rb)2, â€”Oâ€”(CH2)nâ€”N(Rc)2, â€”N(Rd)2, or a cyclic tertiary amine of the group having no or one additional heteroatom, selected from N, O or S, said cyclic tertiary amine being connected directly to a pyrimidine ring of formula 1 or connected to said pyrimidine ring of formula 1 via the linker â€”O(CH2)nâ€”;R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R3/R3â€² are, independently from each other, hydrogen or lower alkyl; (R4)m are, independently from each other in the case where m is not 0 or 1, halogen, trifluoromethyl or lower alkoxy; R5 is hydrogen or lower alkyl; R, Ra, Rb, Rc, Rd, Re, Rf are, independently from each other, hydrogen or lower alkyl; X is N(Rf)C(O)â€”; Y is â€”Oâ€”, â€”Sâ€”, â€”SO2â€”, - or â€”N(R)â€”; n is 1,2,3 or 4; and m is 0,1 or 2; or a pharmaceutically acceptable acid addition salt thereof.