Patent ID: 9045402
Filing Date: 2015-06-02
Classification: C07B,C07C

Abstract:
1. A process of preparing tocotrienol quinone of formula (A): the process comprising the steps a) providing an isomeric mixture of compounds of formula (I-A) b) chemically transforming compound of formula (I-A) to compound of formula (I-B) c) chemically transforming compound of formula (I-B) or of formula (I-A) to compound of formula (I-C) d) chromatographically separating the mixture of isomers of formula (I-A) or (I-B) or (I-C) by means of a chiral phase into the R-isomer (I) and residual (I′); e) collecting the R-isomer (I) being obtained by step d); f) chemically transforming the R-isomer of compound of formula (I-C), represented by a compound of formula (II) by oxidation of the compound of formula (II) by a metal in an oxidation state of at least (I+) to tocotrienol quinone of formula (A) wherein R R R wherein * represents the chiral centre of the chiral isomer of formula (I-A) or (I-B) or (I-C); and wherein step b) is optional and steps d) and e) take place either after step a) or after step b) or after step c).