Patent ID: 6362169
Filing Date: 2002-03-26
Classification: A61K,A61P

Abstract:
An antibacterial composition comprising:(1) a rifamycin derivative of the formula (I) or a physiologically acceptable salt thereof: â€ƒwherein X1 is an oxygen atom or a sulfur atom, R1 is an acetyl group or a hydrogen atom, R2 is a hydrogen atom, a hydroxyl group or an alkyl group having 1 to 3 carbon atoms, and wherein R4 and R5 are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group of the formula: â€ƒin which k is an integer of 1 to 3, a group of the formula: wherein R6 and R7 are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and X2 is an oxygen atom, a sulfur atom, a carbonyl group, a group of the formula: â€ƒin which R8 and R9 are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R8 and R9 are joined to form a group: â€”(CH2)lâ€” in which l is an integer of 1 to 4 or a group of the formula: â€ƒin which m is 0 or 1, R10 hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a group of the formula: â€”(CH2)nX3 in which n is an integer of 1 to 4 and X3 is an alkoxy group having 1 to 3 carbon atoms, a vinyl group, an ethynyl group or a group of the formula: â€ƒand (2) a proton pump inhibitor (a) or a bismuth preparation (b), wherein the components (1) and (2) are used in amounts producing a synergistic effect against Helicobacter pylori.