Patent ID: 8153584
Filing Date: 2012-04-10
Classification: A61K,A61P

Abstract:
1. A method of treating complications arising from or related to low birth weight in a warm blooded animal, comprising: administering to said warm blooded animal a low birth weight complications-reducing or -limiting amount of: i) colony stimulating factor-1 protein (CSF-1); ii) a precursor of CSF-1; iii) a variant of CSF-1, comprising an isoform of CSF-1: iv) an analogue of CSF-1 having retained substantial similarity in biological function to CSF-1; and/or v) a derivative of CSF-1 having retained substantial similarity in biological function to CSF-1; wherein: a) the precursor, variant, analogue, or derivative of CSF-1 comprise the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein; b) the amount administered is at a concentration of 0.1-1 g/kg body weight; and c) the complication treated comprises one or more of the following: low birth weight, underdeveloped kidney, and underdeveloped lung.