Patent ID: 6319488
Filing Date: 2001-11-20
Classification: A61K

Abstract:
An in vivo contrast medium and target tissue combination, wherein said target tissue is selected from the group consisting of inflamed tissue and tumor tissue, said in vivo contrast medium comprising a colloidal system with particles having a size range from 5 nm to 10 .mu.m, said colloidal system further comprising at least one dye fluorescing in the wavelength range from 600 nm to 1200 nm upon direct absorption of monochromatic light in the wavelength range from 600 nm to 1200 nm, said at least one dye is selected from the group consisting of the general formula I, ##STR4##whereinR.sup.1 -R.sup.10 represent the residue E.sup.1, where E.sup.1 is a hydrogen,whereinQ is one of the following fragments: ##STR5##whereinb=0,R.sup.11 represents a hydrogen atom,R.sup.12 represents a hydrogen atom or a saturated or unsaturated, branched or non-branched C.sub.1 -C.sub.50 alkyl chain, and said chain or parts thereof form a cyclic C.sub.5 -C.sub.6, or a bicyclic C.sub.10 unit interrupted and/or replaced by oxygen atoms, sulfur atoms, nitrogen atoms, carboxylic acid ester, carboxylic acid amide, urea, thiourea, carbamate, ether groupings, or represent a hydroxypolyoxyethylene or methoxypolyoxyethylene chain or a branched or non-branched C.sub.1 -C.sub.10 alkyl chain substituted with 1 to 19 fluorine atoms,where X and Y are both ##STR6##fragment,and whereinR.sup.13 and R.sup.14 independently represent hydrogen.