Patent ID: 8912167
Filing Date: 2014-12-16
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition for the inhibition of metastasis, comprising: an anti-metastatic heparin preparation having anti-coagulant activity in the absence of an inhibitor thereof; and a heparin-binding compound which is an inhibitor of the anti-coagulation activity of heparin, having the formula or a pharmaceutically-acceptable salt thereof, wherein R R R each pNPL is, independently, an integer from 0 to 8; pPL1 is an integer from 1 to 5; and A R each R pPL2 is an integer from 1 to 5; and A each R each R or R each R each NPL group is, independently, —B(OR R R each U each LK q1NPL and q2NPL are each, independently, 0, 1, or 2; each PL group is, independently, halo, hydroxyethoxymethyl, methoxyethoxymethyl, polyoxyethylene, or —(NR R each U each V is, independently, nitro, cyano, amino, halo, hydroxy, alkoxy, alkylthio, alkylamino, dialkylamino, amido, alkylamido, dialkylamido, —NH(CH each R R or R each LK each pPL3 is, independently, an integer from 0 to 8; q1PL and q2PL are each, independently, 0, 1, or 2; each t1 is, independently, 0, 1, or 2; and m is an integer from 1 to 20, wherein at least 50% of the heparin-binding compound in the composition is bound to the anti-metastatic heparin preparation in the composition, and wherein the composition is a dry composition.