Patent ID: 7060248
Filing Date: 2006-06-13
Classification: A61K,C07F,C07K

Abstract:
1. A method of detecting, imaging or monitoring congestive heart failure in a patient, comprising the steps of: administering a diagnostic agent to the patient; and acquiring an image of a site of concentration of the diagnostic agent in the patient by a diagnostic imaging technique; wherein the diagnostic agent comprises a diagnostic metal and a compound of the formula: or a pharmaceutically acceptable salt thereof; wherein Q is a matrix metalloproteinase inhibitor of formula (Ia) or (Ib): L K is a chelator having a formula selected from the group: R is independently OH or —CH R R X is independently C═O or SO  and when X is SO R R R R R R R R R R R R R R R R d is selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; W aa is independently at each occurrence an amino acid; Z is selected from the group: aryl substituted with 0-3 R R R R R k is selected from 0, 1, and 2; h is selected from 0, 1, and 2; h′ is selected from 0, 1, and 2; g is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; g′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s″ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; t is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; t′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; x is selected from 0, 1, 2, 3, 4, and 5; x′ is selected from 0, 1, 2, 3, 4, and 5; x″ is selected from 0 and 1; A Pg is a thiol protecting group; E R R R wherein at least one of A R R a pharmaceutically acceptable salt thereof.