Patent ID: 7737136
Filing Date: 2010-06-15
Classification: A61P,C07D

Abstract:
1. A compound according to Formula I, or a pharmaceutically acceptable salt thereof wherein R1, R3, R4, R5 and R10 independently are selected from the group consisting of H, halogen, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, OH, CN, O(1-4C)alkyl, S(O) R2 is selected from the group consisting of H, halogen, NO R6 is selected from the group consisting of H, C(Y)R15, C(O)OR16, C(S)NR17, (1-6C)alkyl, (1-6C)alkoxy-substituted (1-4C)alkyl and (CH R7 is H or R7 is selected from the group consisting of (1-4C)alkyl, (2-4C)alkenyl and (2-4C)alkynyl, all optionally substituted with one or more halogen atoms, R8 and R9 independently are selected from the group consisting of H and (1-4C)alkyl, R11 and R12 independently are selected from the group consisting of H, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-6C)alkoxycarbonyl, (1-4C)alkylsulfonyl, and (6-10C)arylsulfonyl, R15 is H or R15 is selected from the group consisting of (1-6C)alkyl, (3-6C)cycloalkyl, (2-4C)alkenyl or (2-4C)alkynyl, (6-10C)aryl, 1,4-bisaryl, amino(1-4C)alkyl, hydroxyl(1-4C)alkyl, and carboxy(1-4C)alkyl, all optionally substituted with one or more halogen atoms, R16 is (1-6C)alkyl, optionally substituted with one or more halogen atoms, R17 is selected from the group consisting of (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl and (3-6C) cycloalkyl, all optionally substituted with one or more halogen atoms, X is O, Y is selected from the group consisting of O, S, and NH, R18 is selected from the group consisting of H and (1-4C)alkyl, R19 is selected from the group consisting of H and (1-4C)alkyl, R20 is selected from the group consisting of H, (1-4C)alkyl, CH R21 is selected from the group consisting of H and (1-6C)alkyl, m is 0, 1 or 2, and n is 1, 2 or 3, provided that (i) when R1, R2, R3, R4, and R5 are H, R8, R9 and R10 are H, and R6 is ethyl or C(O)CH (ii) when R1, R2, R3, R4, and R5 are H, R8, R9 and R10 are H, and R6 is methyl then R7 is not methyl; and (iii) when R1, R2, R3, R4, and R5 are H, R8, R9 and R10 are H, and R6 is H then R7 is not H or ethyl.