Patent ID: 7576090
Filing Date: 2009-08-18
Classification: A61P,C07D

Abstract:
1. A compound of the general formula (I) or a salt thereof, wherein the substituent —Y—R 1 is attached to the 5- or 6-position of the benzazole; X independently represents S, O, SO, or SO Y independently represents S, O, NR A independently represents ←CO—, ←CS—, ←SO—, ←SO R R R R R R R R R R Z independently represents O, NR R R R R R R R X R m independently represents an integer from 1-3; L is absent or represents a divalent linkage group selected from alkylene, cycloalkylen, heterocyclylen, arylene, or heteroarylen, wherein one or more of the (—CH X R R N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yl]-2-phenyl-acetamide, N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-benzothiazol-2-yl]-2-phenyl-acetamide, N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yl]-3-phenyl-propionamide, N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yl]-2-(3-trifluoromethyl-phenyl)-acetamide, 2-(3,5-bis-trifluoromethylphenyl)-N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yl]-acetamide, 2-(2-chloro-5-trifluoromethyl-phenyl)-N-[6-(6,7-dimethoxy-quinolin-4-yl-oxy)-5-fluoro-benzothiazol-2-yl]-acetamide; wherein an alkyl group, if not stated otherwise, denotes a linear or branched C wherein R′ independently represents H, —CO wherein R″ independently represents H, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl; wherein a cycloalkyl group denotes a non-aromatic ring system containing three to eight carbon atoms, wherein one or more of the carbon atoms in the ring can be substituted by a group E, E being O, S, SO, SO wherein an alkoxy group denotes an O-alkyl group, the alkyl group being as defined above; wherein an alkylthio group denotes an S-alkyl group, the alkyl group being as defined above; wherein an haloalkyl group denotes an alkyl group which is substituted by one to five halogen atoms, the alkyl group being as defined above; wherein a hydroxyalkyl group denotes an HO-alkyl group, the alkyl group being as defined above; wherein a haloalkyloxy group denotes an alkoxy group which is substituted by one to five halogen atoms, the alkyl group being as defined above; wherein a hydroxyalkylamino group denotes an (HO-alkyl) wherein an alkylamino group denotes an HN-alkyl or N-dialkyl group, the alkyl group being as defined above; wherein a halogen group is chlorine, bromine, fluorine or iodine; wherein an aryl group denotes an aromatic group having five to fifteen carbon atoms, which can be substituted by one or more substituents R′, where R′ is as defined above; wherein a heteroaryl group denotes a 5- or 6-membered heterocyclic group which contains at least one heteroatom like O, N, S, wherein the heterocyclic group can be fused to another ring can be substituted by one or more substituents R′, wherein R′ is as defined above.