Patent ID: 6777237
Filing Date: 2004-08-17
Classification: A61K,A61P,C07H

Abstract:
A method of administering a bioactive agent to cells of a targeted tissue site of a subject which comprises administering to said subject an effective amount of the bioactive agent as a bioconjugate, wherein said bioconjugate comprises the bioactive agent and an organocobalt complex wherein the bioactive agent is covalently conjugated to the cobalt atom of the organocobalt complex through a non-reactive atom in the bioactive agent molecule, and wherein said bioconjugate is actively transported into said cells of said targeted tissue site and accumulates in an inactive form until activated by cleavage of the bioactive agent from the organocobalt complex, and which cells of a targeted tissue comprise receptors for the organocobalt complex that mediate endocytotic activity.