Patent ID: 8480631
Filing Date: 2013-07-09
Classification: A61K,A61M,A61P

Abstract:
1. A hazardous agent injection system, the hazardous agent injection system comprising: methotrexate in an amount of from about 0.02 ml to about 4.0 ml and at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector, the needle-assisted jet injector comprising: a container configured to contain the methotrexate; an injection outlet member associated with the container, the injection outlet member including an injection-assisting needle configured to pierce the skin of a patient and deliver a jet of methotrexate to the patient subcutaneously; a firing mechanism associated with the container and configured to expel the methotrexate from the container through the outlet member for injecting the methotrexate; an energy source associated with the firing mechanism and configured to power the firing mechanism and to jet inject the methotrexate from the injection outlet member as a fluid jet; and a trigger mechanism associated with the firing mechanism and configured to activate the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that one or more of confidence intervals of (a) the maximum concentration of methotrexate in blood plasma of a patient following administration of a dose of the methotrexate to the patient (“C