Patent ID: 7824899
Filing Date: 2010-11-02
Classification: C12P

Abstract:
1. A process for the preparation of an enantiomerically enriched amine, comprising: a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; or b) reacting an amine with an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; and c) separating the enantiomerically enriched amide from the enantiomerically enriched amine, wherein said acyl donor is a sulphonylacetic acid ester of the formula 2 wherein R