Patent ID: 7947309
Filing Date: 2011-05-24
Classification: A61K,C12N

Abstract:
1. A method of immunization which comprises mucosally administering a therapeutically effective amount of a pharmaceutical composition to a vertebrate subject, wherein the composition comprises 0.5 mg of an esterified hyaluronic acid molecule wherein approximately 75%-100% of the free carboxyl groups are esterified with an alkyl group (HYAFF) in the form of a microsphere, 10 μg or 20 μg LT-K63, and 10 μg influenza HA antigen, wherein said antigen is entrapped in the microsphere, and further wherein the combination of the 0.5 mg of HYAFF and 10 μg or 20 μg LT-K63 in the composition elicits an enhanced immune response as compared with an immune response elicited by an equivalent amount of the antigen without HYAFF and LT-K63.