Patent ID: 6269312
Filing Date: 2001-07-31
Classification: C07K,C12N,G16B

Abstract:
A method executed by a computer under the control of a program, said computer including a memory for storing said program, said method comprising the steps of:(A) receiving a protein backbone structure with variable residue positions;(B) altering at least one supersecondary structure parameter value of said protein backbone structure;(C) establishing a group of potential rotamers for each of said vahable residue positions, wherein the group of potential rotamers for at least one of said variable residue position has a rotamer selected from each of at least two diferent amino acid side chains; and(D) analyzing the interaction of each of said rotamers with all or part of the remainder of said protein backbone structure to generate a set of optimized protein sequences wherein said analyzing step includes a Dead-End Elimination (DEE) canmputation.