Patent ID: 6747144
Filing Date: 2004-06-08
Classification: A61P,C07D

Abstract:
A compound of formula II: wherein R2 and R3 are independently selected from: H, R, OH, OR, &boxH;O, &boxH;CHâ€”R, &boxH;CH2, CH2â€”CO2 R , CH2â€”CO2H, CH2-SO2R, Oâ€”SO2R, CO2R, COR and CN, and there is optionally a double bond between C1 and C2 or C2 and C3;R6, R7, R8 and R9 are independently selected from H, R, OH, OR, halo, nitro, amino, Me3Sn; or R7 and R8 together form a group â€”Oâ€”(CH2)pâ€”Oâ€”, where p is 1 or 2; where R is a lower alkyl group having 1 to 10 carbon atoms, or an aralkyl group of up to 12 carbon atoms, whereof the alkyl group optionally contains one or more carbonâ€”carbon double or triple bonds, which may form part of a conjugated system, or an aryl group of up to 12 carbon atoms; and is optionally substituted by one or more halo, hydroxy, amino, or nitro groups, and optionally contains one or more hetero atoms, which may form part of, or be, a functional group; except thatone or more of R6, R7, and R8 are independently Xâ€”Yâ€”Aâ€”, where X is selected from â€”COZâ€², NHZ, SH, or OH, where Z is either H or a nitrogen protecting group, Zâ€² is either OH or an acid protecting group, Y is a divalent group such that HY=R, and A is O.