Patent ID: 8236924
Filing Date: 2012-08-07
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating or reducing the likelihood of hearing loss in a subject, the method comprising administering to the subject a peptide consisting of an amino acid sequence at least 95% identical to an amino acid sequence selected from a group consisting of amino acid sequences of SEQ ID NO:23, the amino acid sequence of TDQSRPVQPFLNLTTFPRKPR in which all of the amino acids are in the D configuration, and the amino acid sequence of TDQSRPVQPFLNLTTFPRKPRPPRRRQRRKKRG in which all of the amino acids are in the D configuration, wherein the peptide directly inhibits at least one c-Jun amino terminal kinase (JNK) protein.