Patent ID: 9150628
Filing Date: 2015-10-06
Classification: A61K,A61P,C07K

Abstract:
1. An isolated inhibitor of the nucleic enzyme poly(adenosine 5′-diphospho-ribose) polymerase (PARP) having phosphoesterase activity, comprising: an amino acid sequence consisting of macroH2A1.1 (amino acids 121 to 369 of SEQ ID NO: 1), macroH2A1.2 (amino acids 120 to 371 of SEQ ID NO: 2), or macroH2A2 (amino acids 121 to 372 of SEQ ID NO: 3), wherein the amino acid sequence is fused to a heterologous sequence selected from the group consisting of a nuclear localization sequence, a His tag, a GST protein, a FLAG tag, an HA tag, and combinations thereof.