Patent ID: 6071947
Filing Date: 2000-06-06
Classification: A61P,C07D

Abstract:
A compound which is a (1H-indol-2-yl)-5[(2H-pyrrol-2-ylidene)methyl]-1H-pyrrole derivative of formula (I) ##STR10## wherein each of R1, R2, R3 and R4, which are the same or different, independently represents hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, cyano, nitro, hydroxy, C.sub.1 -C.sub.6 alkoxy unsubstituted or substituted by phenyl, C.sub.1 -C.sub.6 alkyl-carbonyloxy, --NRaRb in which each of Ra and Rb independently is hydrogen or C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyl-carbonylamino, carboxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, aralkyl-carbamoyl, arylcarbamoyl or --CONRcRd in which each of Rc and Rd independently is hydrogen or C.sub.1 -C.sub.6 alkyl, or Rc and Rd, taken together with the nitrogen atom to which they are linked, form a morpholino or piperidino ring;R5 represents halogen, hydroxy or C.sub.1 -C.sub.11 alkoxy unsubstituted or substituted by phenyl; andR6 represents hydrogen, C.sub.2 -C.sub.20 alkanoyl, C.sub.3 -C.sub.20 alkenoyl, phenyl, C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl, wherein the alkanoyl, alkenoyl, alkyl and alkenyl groups are each unsubstituted or substituted by 1 to 3 substituents chosen independently from halogen, C.sub.1 -C.sub.6 alkoxy, hydroxy, aryl, aryloxy, cyano, carboxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, (C.sub.3 -C.sub.4 alkenyl)carbamoyl, aralkylcarbamoyl, arylcarbamoyl and --CONRcRd wherein Rc and Rd are as defined above;or a pharmaceutically acceptable salt thereof.