Patent ID: 6627633
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A compound of the following formula: wherein:R1 are the same or different and independently selected from the group consisting of: H; C1-C4-straight chain alkyl; and C3-C4-branched chain alkyl; X=N; R2=phenyl; substituted phenyl, wherein the substituents (1-2 in number) are in any position and are independently selected from the group consisting of R1, OR1, SR1, S(O)R1, S(O2)R1, NHR1, NO2, OC(O)CH3, NHC(O)CH3, F, Cl, Br, CF3, C(O)R1, phenyl, C(O)NHCHR1CH2OH; 1-naphthyl; 2-naphthyl; heterocycles selected from the group consisting of: 2-pyridyl; 3-pyridyl; 4-pyridyl; 5-pyrimidyl; thiophene-2-yl; thiophene-3-yl; 2-furanyl; 3-furanyl; 2-benzofuranyl; benzothiophene-2-yl; 2-pyrrolyl; 3-pyrrolyl; 2-quinolinyl; 3-quinolinyl; 4-quinolinyl; 1-isoquinolinyl; 3-isoquinolinyl; and 4-isoquinolinyl; or substituted heterocycle, wherein the substituents (1-2 in number) are in any position and are independently selected from the group consisting of Br, Cl, F, R1, and C(O)CH3; R3 are the same or different and independently selected from the group consisting of: H; C1-C4-straight chain alkyl; C3-C4-branched chain alkyl; C2-C4-alkenyl chain; (CH2)nPh; and (CH2)n-substituted phenyl, wherein the phenyl substituents are as defined above in R2; R4=H; C1-C4-straight chain alkyl; or C3-C4-branched chain alkyl; R3 and R4 can be linked together by a carbon chain to form with intervening atoms a 5-8-membered ring; n=0-3; Y=H; OR1; NHR1; NHC(O)R3; NHSO2R3; NHC(O)NHR3; NHC(O)R5; or NHC(O)OR6; R5=C3-C7-cycloalkyl; R6=C1-C4-straight chain alkyl; C3-C4-branched chain alkyl; C2-C4-alkenyl chain; (CH2)nPh; or (CH2)n-substituted phenyl, wherein the phenyl substituents are as defined above in R2; or a pharmaceutically acceptable salt thereof.