Patent ID: 7393540
Filing Date: 2008-07-01
Classification: A61K,A61P,C07K

Abstract:
1. An isolated M. tuberculosis peptide selected from the group consisting of SEQ ID NOs: 7, 55, 125 and 129 or a variant thereof having at least 70% amino acid homology therewith, or a fusion protein thereof, wherein said fusion protein or variant has a common antigenic cross-reactivity to said isolated peptide; wherein the peptide is encoded by an M. tuberculosis gene the expression of which is induced or up regulated under culture conditions that are nutrient starving and which maintain mycobacterial latency, said conditions being obtainable by batch fermentation of an M. tuberculosis micobacterium for at least 40 days post inoculation, when compared with culture conditions that are not nutrient starving and which support exponential growth of said mycobacterium .