Patent ID: 8058251
Filing Date: 2011-11-15
Classification: A61M,A61P,C12N

Abstract:
1. A method for improving memory or cognitive function in a subject diagnosed as having a disorder in which a diminished declarative memory is a symptom, comprising intracranially administering to the subject a therapeutically effective dose of a composition that decreases the expression of a beta amyloid cleaving enzyme type 1, or BACE1, in a cell of the nervous system of the subject, wherein the composition comprises a shRNA or a siRNA or a vector encoding said siRNA or said shRNA, wherein further said shRNA or said siRNA comprises a double-stranded portion 21 to 30 nucleotides long and wherein one strand of said double-stranded portion comprises 21 contiguous nucleotides encoded by SEQ ID NO: 29, and wherein at least one attribute of said memory or cognitive function is improved.