Patent ID: 7544659
Filing Date: 2009-06-09
Classification: A61K,A61P

Abstract:
1. A method of promoting axonal growth or regeneration comprising delivering to an injured neuron an effective amount of a Netrin G1 Ligand polypeptide (NGL-1 polypeptide) that comprises a non-human homologue of NGL-1 selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 4 lacking the N-terminal methionine, SEQ ID NO: 4 lacking an N-terminal signal sequence consisting of the amino acid sequence of residues 1-42 of SEQ ID NO:4, SEQ ID NO: 4 lacking all or part of the immunoglobulin-like region consisting of the amino acid sequence of residues 364-428 of SEQ ID NO:4, glycosylation variants thereof, and a fusion peptide comprising any of said preceding polypeptides fused to a heterologous amino acid sequence, where the NGL-1 polypeptide comprises a transmembrane region, and wherein said NGL-1 polypeptide is effective to bind to and signal through a Netrin-G1 receptor.