Patent ID: 8383652
Filing Date: 2013-02-26
Classification: A61K,A61P,A61Q,C07C,C07D

Abstract:
1. A biaromatic compound having the formula (I): in which: R1 is a radical —OR6, a radical —NR6OR6, or a radical NR6R6, wherein R6 is as defined below; R2 is a halogen atom, an alkyl radical having from 1 to 12 carbon atoms, a radical —OR7, a radical —NHR7, or an aralkyl radical, wherein R7 is as defined below; R3 is an alkyl radical having from 1 to 12 carbon atoms, a cycloalkyl radical having from 3 to 12 carbon atoms, or a sequence —(CH X is the following sequence: wherein w, z, R9, R10 and Y are as defined below, m is an integer ranging from 0 to 4; Y is an oxygen or sulfur atom; z and w are each 0 or 1; Ar1 and Ar2 are each an aromatic radical optionally substituted with a radical R4 or R5 as defined below and having the formula: for Ar1: for Ar2: wherein the groups Ar2 and XR3 are in a meta arrangement on the aromatic radical Ar1 and the groups Ar1 and CH═CR2-COR1 are in para arrangement on the aromatic radical Ar2; R4 and R5, which are identical or different, are each a hydrogen atom, a halogen atom, an alkyl radical having from 1 to 12 carbon atoms, a hydroxyl radical, an alkoxy radical, a polyether radical, an aralkyl radical, an aryl radical, or an amino radical that is optionally substituted with one or two radicals, which are identical or different, selected from an alkyl radical having from 1 to 12 carbon atoms and an aralkyl radical; R6 is a hydrogen atom, an alkyl radical having from 1 to 7 carbon atoms, an aryl radical or an aralkyl radical; R7 is a hydrogen atom, an alkyl radical having from 1 to 7 carbon atoms, an aryl radical or an aralkyl radical; R8 is an alkyl radical having from 1 to 7 carbon atoms, a cycloalkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocycloalkyl radical, a radical —OR11, or a substituted or unsubstituted amine function; R9 and R10, which are identical or different, are each a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; R11 is a hydrogen atom, an alkyl radical having from 1 to 7 carbon atoms, an aryl radical or an aralkyl radical; or a pharmaceutically acceptable salt thereof; wherein the wavy line indicates that the compound has the (E) or (Z) configuration.