Patent ID: 6355639
Filing Date: 2002-03-12
Classification: A61K

Abstract:
A method for treating a subject in need of immunosuppression, comprising administering to the subject an effective amount of a compound having the structure: wherein R1, R6 and R7 are independently hydrogen, OH, NH2, SH, halogen, C1-C9 linear or branched chain alkyl, alkylmercapto, alkylamino, dialkylamino, alkoxy, phenyl, alkylphenyl, dialkylphenyl, halophenyl, alkoxyphenyl, hydroxyphenyl, benzyl, or hydroxybenzyl; wherein R0, and R2 are independently hydrogen, OH, C1-C9 linear or branched chain alkyl, â€”CR3R3â€”CH(O)CH2, â€”CR3R3â€”CH2CH3, â€”CR3R3â€”CH2CH2OH, â€”CR3R3â€”CH(OH)R4 or â€”CR3R3â€”CH&boxH;CHR4; wherein R3 and R4 are independently hydrogen, halogen, C1-C9 linear or branched chain alkyl, phenyl, alkylphenyl, dialkylphenyl, alkoxyphenyl, or benzyl; wherein R5 is hydrogen, C1-C9 linear or branched chain alkyl, phenyl, alkylphenyl, dialkylphenyl, alkoxyphenyl, benzyl, alkoxybenzyl, dialkoxybenzyl, indolylmethyl, alkylmercapto, or arylmercapto; and wherein R8 is hydrogen, C1-C9 linear or branched chain acyl, benzoyl, alkylbenzoyl, dialkylbenzoyl, alkoxybenzoyl, benzyl, or C1-C9 linear or branched chain alkyl.