Patent ID: 6500433
Filing Date: 2002-12-31
Classification: A61K,A61P,C07K

Abstract:
A polypeptide selected from the group consisting of:a) a first polypeptide consisting of i) a sequence of no more than 100 consecutive amino acids of SAI/II (SEQ. ID. NO: 23) which said sequence comprises the amino acid sequence of residues 1025-1044 of SAI/II (residues 2-21 of SEQ ID NO: 9) or residues 1024-1044 (SEQ. ID. NO: 9); or ii) modified amino acid sequence which differs from the sequence of i) by up to and including 8 amino acid alterations wherein said alterations consist of the substitution and/or deletion and/or insertion of up to and including 8 amino acids wherein the polypeptide containing said modified amino acid sequence has the same immunological and adhesion properties as the polypeptide of i); and b) a second polypeptide which is an extended form of said first polypeptide of i) or ii), which second polypeptide comprises said first polypeptide extended at the N-terminus or the C-terminus of said first polypeptide, or both, with non-wild-type amino acid sequence to form said second polypeptide; wherein non-wildtype amino acid sequence is defined as an amino acid sequence which does not natively occur at the N-terminus or C-terminus of said first polypeptide in SAI/II (SEQ. ID. NO: 23); and wherein said first polypeptide or second polypeptide may be in the N-terminal acylated and/or C-terminal amidated form.