Patent ID: 6342598
Filing Date: 2002-01-29
Classification: A61K,C07C,C07F,C07J,Y10S

Abstract:
A compound, either racemic or enantiomeric, of the formulae (â€ ) and corresponding metal chelates: in which n and m are 1 or 0 but not simultaneously 1, and when n=m=0, Râ€² is H, and R* is a C12-25 linear or branched, saturated or unsaturated, hydrocarbon radical; when n=1 and m=0, R* is H or a C1-3 alkyl or alkenyl substituent; and Râ€² is selected from â€”NHR3, â€”NR4R5 and â€”OR6 where the R3 to R6 are independently C12â‰…linear or branched, saturated or unsaturated, hydrocarbon radicals optionally interrupted by â€”COâ€” and/or â€”Oâ€” and optionally terminated by â€”NR7R8 in which R7 and R8 are independently H or C12-25 hydrocarbon radicals; and when n=0 and m=1, R* is H or a C1-3 alkyl or alkenyl substituent; and Râ€² is selected from R9 and CH2â€”Oâ€”COâ€”R9 in which R9 is a C10-30 linear or branched, saturated or unsaturated, hydrocarbon radical optionally interrupted by â€”NHâ€”, â€”NR10â€”, â€”COâ€” or â€”Oâ€”, R10 being a lower aliphatic hydrocarbon wherein the metal in the metal chelate is a paramagnetic metal ion selected from Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III).