Patent ID: 6689856
Filing Date: 2004-02-10
Classification: A61K,A61Q,C08F

Abstract:
A water-soluble polymer comprising a water-soluble backbone and side units having in water a lower critical solution temperature, LCST, the polymer being obtainable by free-radical precipitation polymerization of:a) one or more water-soluble monomers (Ia) and, optionally, of one or more hydrophobic monomers (Ib) in a smaller amount relative to the monomer(s) (Ia), the monomers (Ia) and (Ib) bearing at least one unsaturated function that can be polymerized to form the water-soluble backbone; b) one or more macromonomers corresponding to formula (II): Aâ€”Xâ€”Bâ€ƒâ€ƒ(II), in which A is a group comprising at least one unsaturated hydrocarbon-based bond that may be polymerized; X is a group chosen from â€”Oâ€”, â€”Sâ€”, â€”PHâ€”, â€”NHâ€” and NRÂ° in which RÂ° is an alkyl group of 1 to 6 carbon atoms; and B is a unit with an LCST whose heat-induced demixing temperature in aqueous solution is from 5 to 40Â° C. for a concentration by weight in water of 1% of said unit.