Patent ID: 7390896
Filing Date: 2008-06-24
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A process for preparing a compound of Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, comprising an amide bond synthesis coupling a carboxylic acid 1 and an amine 2 including amide coupling methods comprising HATU, TBTU, BOP, EDC, CDI, and DCC-mediated couplings: wherein the product, 3, comprises Formula (I) wherein: R n is 0, 1, 2, or 3, m is 0, 1, 2, or 3; l is 1, 2, or 3; Ring C is a 3 to 8 membered carbocycle, R R R R R R R R R R B is R R R additionally, two R additionally, two R W is —(CR p is 0, 1, 2, 3, or 4; R X is a bond; R Y is a bond or —(CR t is 0, 1, 2, or 3; u is 0, 1, 2, or 3; R V is a bond, —C(═O)—, —O—, —S—, —S(═O)—, —S(═O) Z is H; R R R R R R R R R R R R R R R R R R R R additionally, two R additionally, two R additionally, two R R R R R