Patent ID: 8703130
Filing Date: 2014-04-22
Classification: A61K,A61P,C07K

Abstract:
1. A method of treatment of a patient suffering from a cancer associated with tumor angiogenesis, said method comprising the step of administering a bispecific antibody to a patient in the need of such treatment, said bispecific antibody being one that binds specifically to human vascular endothelial growth factor (VEGF) and human angiopoietin-2 (ANG-2) and comprises a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, wherein: i) said antigen-binding sites each comprise an antibody heavy chain variable domain and an antibody light chain variable domain; ii) said first antigen-binding site comprises in the heavy chain variable domain: iii) said second antigen-binding site comprises in the heavy chain variable domain: