Patent ID: 9180215
Filing Date: 2015-11-10
Classification: A61K,A61P,C07B,C07D

Abstract:
1. A method of diagnosing or monitoring in a patient a folate receptor expressing cancer, the method comprising the steps of: a. administering to the patient an effective amount of a composition comprising a compound of the formula wherein V is a folate receptor binding moiety, or an analog or derivative thereof; L is an optional bivalent linker; n is an integer selected from 1 to about 100; and Ar is an aryl group that includes one or more independently selected substituents, R f , wherein R f comprises a radiophore or a precursor to a radiophore; and an optional carrier therefor; b. allowing sufficient time for the compound to bind to the cancer; c. detecting the compound bound to the cancer with an extra-corporeal PET imaging device; and d. diagnosing or monitoring the cancer extra-corporally using positron emission tomography.