Patent ID: 8586716
Filing Date: 2013-11-19
Classification: A61P,C07K

Abstract:
1. An isolated antibody that binds the extracellular domain of EphB3, wherein the antibody comprises six CDR regions selected from the group consisting of: (a) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2 and CDR-H3 of antibody XPA.04.001, wherein the light chain variable region sequence of XPA.04.001 is set out in SEQ ID NO: 3 and the heavy chain variable sequence of XPA.04.001 is set out in SEQ ID NO: 4; (b) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2 and CDR-H3 of antibody XPA.04.013, wherein the light chain variable region sequence of XPA.04.013 is set out in SEQ ID NO: 5 and the heavy chain variable sequence of XPA.04.013 is set out in SEQ ID NO: 6; (c) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2 and CDR-H3 of antibody XPA.04.018, wherein the light chain variable region sequence of XPA.04.018 is set out in SEQ ID NO: 7 and the heavy chain variable sequence of XPA.04.018 is set out in SEQ ID NO: 8; and (d) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2 and CDR-H3 of antibody XPA.04.048, wherein the light chain variable region sequence of XPA.04.048 is set out in SEQ ID NO: 9 and the heavy chain variable sequence of XPA.04.048 is set out in SEQ ID NO: 10.