Patent ID: 7199133
Filing Date: 2007-04-03
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula I of category I, II, III or VI in which in category I) E is phenyl, which is monosubstituted by R R W is OCHAr′, OCHA, NHCHAr′, NHCHA, NHCOOCHAr′, or NHCONHCHAr′, Ar′ is phenyl which is unsubstituted or monosubstituted or disubstituted by Hal, A or CF A is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, Y is Ar-diyl, R R X is CONR T is (CH R Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, —[C(R Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Het′ is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Hal is F, Cl, Br or I, n is 0, 1 or 2, m is 0, 1 or 2, o is 1, 2 or 3, and p is 3, or in category II) E is phenyl, which is monosubstituted by R R W is OCHAr′, OCHA, NHCHAr′, NHCHA, NHCOOCHAr′, or NHCONHCHAr′, Ar′ is phenyl which is unsubstituted or monosubstituted or disubstituted by Hal, A or CF A is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, X is CONH, and Y is Ar-diyl, R R T is (CH R Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, —[C(R Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Het′ is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Hal is F, Cl, Br or I, n is 0, 1 or 2, m is 0, 1 or 2, o is 1, 2 or 3, and p is 3, or in category III) E is phenyl, which is monosubstituted by R R W is OCHAr′, OCHA, NHCHAr′, NHCHA, NHCOOCHAr′, or NHCONHCHAr′, Ar′ is phenyl which is unsubstituted or monosubstituted or disubstituted by Hal, A or CF A is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, X is CONH, Y is Ar-diyl, and T is (CH R R Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, —[C(R Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Het′ is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, Hal, A, —[C(R Hal is F, Cl, Br or I, n is 0, 1 or 2, m is 0, 1 or 2, and o is 1, 2 or 3, or in category IV) E is phenyl, which is monosubstituted by R R W is OCHAr′, OCHA, NHCHAr′, NHCHA, NHCOOCHAr′, or NHCONHCHAr′, Ar′ is phenyl which is unsubstituted or monosubstituted or disubstituted by Hal, A or CF A is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, X is CONH, Y is Ar-diyl, T is (CH Ar is phenyl which is unsubstituted or monosubstituted or disubstituted by Hal, A or CF Hal is F, Cl, Br or I, or a pharmaceutically acceptable salt thereof.