Patent ID: 6017958
Filing Date: 2000-01-25
Classification: A61K,A61P,C07C

Abstract:
A method of treating a malignant tumor sensitive to the compounds below, in a mammal, the method conprising administering to said mammal an effective amount of a thyroxine analogue having no significant hormonal activity, in an amount sufficient to depress growth of the malignant tumor, wherein the thyroxine analogue is characterized as being a compound capable of causing about 35 percent or more inhibition of initial velocity of microtubule protein assembly in vitro wherein said thyroxine analogue has the formula: ##STR8## and pharmaceutically acceptable salts thereof, wherein: X=O, S, CH.sub.2, carboxy or absent;Y=O or S;R.sub.1 =methyl or ethyl;R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of: H, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkenyl, (C.sub.1 -C.sub.4) alkynyl, hydroxyl, (C.sub.1 -C.sub.4) alkoxy and halogen; andR.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently selected from the group consisting of: H, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkenyl, (C.sub.1 -C.sub.4) alkynyl, hydroxyl, (C.sub.1 -C.sub.4) alkoxy, halogen, NO.sub.2 and NH.sub.2.