Patent ID: 7252819
Filing Date: 2007-08-07
Classification: A61K,A61P,C12N

Abstract:
1. A method of establishing an electrical connection between a recombinant mammalian cell and a myocardial cell, the method comprising: contacting a myocardial cell of a subject with a recombinant mammalian cell genetically modified to express a recombinant connexin 43 protein, wherein the recombinant cell is a myoblast cell or a cardiomyocyte, wherein the recombinant cell is autologous or allogeneic to the subject, and wherein said contacting is performed by injection into cardiac tissue of the subject or is performed by cardiovascular infusion into the subject and in a manner sufficient to provide for production of an electrical connection between the myocardial cell and the recombinant cell; wherein an electrical connection between the recombinant cell and the myocardial cell is established.