Patent ID: 6127190
Filing Date: 2000-10-03
Classification: B01J,C07B,C07K,C40B,G01N

Abstract:
A method of making a combinatorial library of test compounds, the method comprising the steps of:(a) selecting two or more pieces of a physically and repetitively divisible solid phase support to each of which is attached only one type of a number of types of subunits, wherein the subunits have a reactive group protected with a protecting group, the number of types of subunits is equal to the number of pieces of selected support, and each type of subunit is attached to only one piece of support;(b) removing the protecting group thereby providing the reactive group;(c) dividing each piece of support into a number of physically separate pieces, the number of pieces being equal to the number of types of subunits; and(d) attaching one type of subunit of the number of types of subunits to each type of subunit attached to each piece of support so that a number of different species of test compounds is formed, each species of test compound being formed on only one piece of support, each test compound comprising a plurality of subunits, wherein the number of types of subunits of the test compounds is equal to the number of pieces of support selected in step (a), only one type of species of test compound is formed on each support, and the number of species of test compounds is equal to the number of pieces of support.