Patent ID: 6057422
Filing Date: 2000-05-02
Classification: A61K,A61P,C07K

Abstract:
A peptide selected from the group having the formulae:X-R.sup.1 -R.sup.2 -Asp-Ala-R.sup.5 -R.sup.6 -Thr-R.sup.8 -R-.sup.9 R-.sup.10 -Arg-R.sup.12 -R.sup.13 -R.sup.14 -R.sup.15 -R.sup.16 -Leu-R.sup.18 -R.sup.19 -Arg-R .sup.21 -R.sup.22 -Leu-GIn-Asp-Ile-R.sup.27 -R.sup.28 -R.sup.29 -NH.sub.2wherein X is PhAc, IndAc, or Nac,R.sup.1 is Tyr or His,R.sup.2 is D-Arg,R.sup.5 is Ile or Val,R.sup.6 is Phe, or Phe(CI)R.sup.8 is Asn, Gin, Ala,or D-Asn,R.sup.9 is Arg, Har, Lys, Orn, D-Arg, D-Har, D-Lys, D-Om, Cit, Nle, Tyr (Me), Ser, Ala or AibR.sup.10 is Tyr or Tyr(Me),R.sup.12 is Lys,R.sup.13 is Val or Nle,R.sup.14 is Leu or Nle,R.sup.15 is Gly, Ala, Abu, Nle or Gln,R.sup.16 is Gln or Arg,R.sup.18 is Ser or Nle,R.sup.19 is Ala,R.sup.21 is Lys,R.sup.22 is Leu, Ala or Aib,R.sup.27 is Met, Leu, Nle, Abu, or D-Arg,R.sup.28 is Arg, D-Arg,or Ser,R.sup.29 is Arg, D-Arg, Har or D-Har,Provided that where R.sup.9 and R.sup.28 are Ser, R.sup.29 is other than Arg or Har and pharmaceutically acceptable salts thereof.