Patent ID: 8236931
Filing Date: 2012-08-07
Classification: A61P,C07K

Abstract:
1. An isolated antibody comprising a light chain variable domain framework 1 region having at least one amino acid substitution selected from the group consisting of a Kabat position 9 amino acid substitution, a Kabat position 10 amino acid substitution, a Kabat position 11 amino acid modification substitution, a Kabat position 12 amino acid substitution, a Kabat position 13 amino acid substitution and a Kabat position 14 amino acid modification substitution; wherein: the Kabat position 9 amino acid substitution is selected from the group consisting of proline, tryptophan and tyrosine; the Kabat position 10 amino acid substitution is selected from the group consisting of tryptophan, leucine and tyrosine; the Kabat position 11 amino acid substitution is selected from the group consisting of proline, tryptophan, phenylalanine, and tyrosine; the Kabat position 12 amino acid substitution is selected from the group consisting of tryptophan, phenylalanine, leucine and tyrosine; the Kabat position 13 amino acid substitution is selected from the group consisting of tryptophan, phenylalanine, leucine and tyrosine; and the Kabat position 14 amino acid substitution is selected from the group consisting of proline, tryptophan, phenylalanine, leucine and tyrosine.