Patent ID: 8716337
Filing Date: 2014-05-06
Classification: A61K,A61P

Abstract:
1. A method for forming an improved drug system with an optimized bioavailability comprising the steps of: forming a drug substance consisting essentially of A-B-C wherein A is an amine containing pharmaceutically active compound; C is a first dissolution modifying amine and B is a bidentate linking group used to covalently or ionically link A and C defined by the formula: wherein Y R G R R R measuring a dissolution profile at pH intervals representing gastric, intestinal and aqueous conditions; comparing said dissolution profiles against a predetermined standard; forming a second drug substance consisting essentially of A-B-C′ wherein A is said amine containing pharmaceutically active compound; C′ is a second dissolution modifying amine and B is said bidentate linking group used to covalently or ionically link A and C wherein said second dissolution modifying amine has a different hydrophilicity than said first dissolution modifying amine; and measuring a second dissolution profile of said second drug substance at pH intervals representing gastric, intestinal and aqueous conditions wherein at least one of said first dissolution modifying amine or said second dissolution modifying amine is defined by the formula: wherein at least one of R