Patent ID: 8067423
Filing Date: 2011-11-29
Classification: A61P,C07D

Abstract:
1. An isopropyl alcohol solvate of dasatinib characterized by data selected from a group consisting of: a powder x-ray diffraction pattern having any three peaks selected from the group consisting of: 6.0, 11.9, 12.0, 14.9, 17.9, 18.3, 18.8, 21.4, 22.9, 24.2 and 24.7±0.2 degrees 2-theta, a powder x-ray diffraction pattern as depicted in FIG. 18 , a solid-state 13 C NMR spectrum having signals at 139.2 and 127.6±0.2 ppm; a solid-state 13 C NMR spectrum having chemical shift differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 14.2 and 2.6±0.1 ppm; and a unit cell with the following parameters as determined by crystal structure determination using synchrotron powder diffraction data: a powder x-ray diffraction pattern and calculated powder x-ray diffraction pattern as depicted in