Patent ID: 7476752
Filing Date: 2009-01-13
Classification: C07C

Abstract:
1. A process for preparing a compound of Formula I: wherein: R is C R R R or R Het is a heterocyclic ring system of 4-14 ring atoms comprising one to four ring-forming heteroatoms; wherein at least one of R 1 , R 1a and R 2 is other than hydrogen; comprising: a) reacting a compound of Formula II: in a non-protic solvent with a compound of Formula III: wherein R 1 , R 1 , R 1a , R 2 are defined above and X is Cl, Br or I; and b) reacting a compound of Formula IV: wherein R 3 is as defined above and X′ is chloro, bromo, iodo, OSO 2 CH 3 , OSO 2 CF 3 , OSO 2 Ph(4-Me), OSO 2 Ph(4-CF 3 ), OSO 2 Ph(4-Br), OSO 2 Ph(4-Cl), OSO 2 Ph(4-F), OSO 2 OR 3 , or OPO 2 OR 3 , with the reaction mixture of step a) to form said compound of Formula I.