Patent ID: 6184250
Filing Date: 2001-02-06
Classification: A61K,C07C,Y10S

Abstract:
A method of treating glaucoma and ocular hypertension which comprises topically administering to the affected eye a composition comprising a therapeutically effective amount of a combination of a first compound selected from the group consisting of beta-blockers, carbonic anhydrase inhibitors, adrenergic agonists, and cholinergic agonists; together with a second compound having the absolute stereochemical structure of the following formula (IV): ##STR18##wherein:R.sub.1 =H; C.sub.1 -C.sub.12 straight-chain or branched alkyl; C.sub.1 -C.sub.12 straight-chain or branched acyl; C.sub.3 -C.sub.8 cycloalkyl; or a cationic salt moiety;R.sub.2, R.sub.3 =H, or C.sub.1 -C.sub.5 straight-chain or branched alkyl; or R.sub.2 and R.sub.3 taken together may represent O;X=O, S, or CH.sub.2 ;- - - represents any combination of a single bond, or a cis or trans double bond for the alpha (upper) chain; and a single bond or trans double bond for the omega (lower) chain;R.sub.9 =H, C.sub.1 -C.sub.10 straight-chain or branched alkyl, or C.sub.1 -C.sub.10 straight-chain or branched acyl;R.sub.11 =H, C.sub.1 -C.sub.10 straight-chain or branched alkyl, or C.sub.1 -C.sub.10 straight-chain or branched acyl;Y=O; or H and OR.sub.15 in either configuration wherein R.sub.15 =H, C.sub.1 --C.sub.10 straight-chain or branched alkyl, or C.sub.1 -C.sub.10 straight-chain or branched acyl; andZ=Cl or CF.sub.3 ;with the proviso that when R.sub.2 and R.sub.3 taken together represent O, then R.sub.1.noteq.C.sub.1 -C.sub.12 straight-chain or branched acyl; and when R.sub.2 =R.sub.3 =H, then R.sub.1.noteq.a cationic salt moiety.