Patent ID: 6573245
Filing Date: 2003-06-03
Classification: A61K,A61P,C07H

Abstract:
A polysaccharide adjuvant-protein antigen conjugate, wherein said conjugate is represented by the formula:(Aâ€”Lâ€²)yâ€”Pâ€”(Lâ€”I)x or pharmaceutically acceptable salts thereof, whereP is a polysaccharide which will bind to the cell surface of an Antigen Presenting Cell; each Lâ€² is the same or different and is a covalent bond, or a bifunctional linking molecule; A is a protein or peptide antigen which will elicit an immunogenic response when covalently attached to a polysaccharide backbone, and wherein when y is greater than 1, each A can be the same or different protein or peptide; each L is the same or different and is a covalent bond, or a bifunctional linking molecule; and I is an compound having a stable carbonyl group capable of reacting with an amino group on an Antigen Presenting Cell to form an imine or Schiff's base, said compound having (a) a ketone or aldehyde functionality; and (b) a second functional group which reacts with a complementary functional group present on said polysaccharide or said bifunctional linking molecule, if present, and wherein when x is greater than 1, each I can be the same or different; x is from 1 to 100 units per 100 glycoside residues; and y is from 1 to about 20 units per 100 glycoside residues.