Patent ID: 6506772
Filing Date: 2003-01-14
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is unsubstituted lower alkoxy, cycloalkyl or aryl, or lower alkoxy, cycloalkyl or aryl substituted by halogen or lower alkoxy, or is â€”NRâ€²Râ€³, wherein Râ€² and Râ€³ are, independently selected from, hydrogen, lower alkyl, lower alkenyl, lower alkinyl, unsubstituted â€”(CR2)n-aryl, or â€”(CR2)n-aryl substituted by one to three substituents, selected from the group, consisting of halogen or lower alkoxy, or are â€”(CH2)n+1NRa2, â€”(CH2)n-pyridinyl, â€”(CH2)n-indanyl, â€”(CH2)n-cycloalkyl, â€”(CH2)nâ€”O-lower alkyl, â€”(CH2)nâ€”C(O)â€”NRb2, â€”(CH2)nâ€”CF3, or Râ€² and Râ€³ are together with the N atom to which they are attached form unsubstituted pyrrolidin-1-yl, piperidin-1-yl, 3,4-dihydro-1H-isoquinolin-2-yl, morpholinyl, azatidin-1-yl, 3,6-dihydro-2H-pyridin-1-yl, thiomorpholinyl, 2,5-dihydro-pyrrol-1-yl, thiazolidin-3-yl, piperazinyl, azocan-1-yl, azepan-1-yl, octahydroquinolin-1-yl, octahydroquinolin-2-yl, 1,3,4,9-tetrahydro-b-carbolin-2-yl, or pyrrolidin-1-yl, piperidin-1-yl, 3,4-dihydro-1H-isoquinolin-2-yl, morpholinyl, azatidin-1-yl, 3,6-dihydro-2H-pyridin-1-yl, thiomorpholinyl, 2,5-dihydro-pyrrol-1-yl, thiazolidin-3-yl, piperazinyl, azocan-1-yl, azepan-1-yl, octahydroquinolin-1-yl, octahydroquinolin-2-yl, 1,3,4,9-tetrahydro-b-carbolin-2-yl substituted by one to three substituents, selected from the group consisting of lower alkyl, phenyl, benzyl, pyridyl, â€”C(O)â€”NRc2, â€”(CH2)nâ€”O-lower alkyl or â€”NRdâ€”(C(O)-lower alkyl; R2 is unsubstituted aryl or a 5 or 6 membered heteroaryl group, or aryl or a 5 or 6 membered heteroaryl group substituted by lower alkyl, halogen, hydroxy or lower alkoxy; X is a bond or â€”N(Re)CH2â€”; R, Ra, Rb, Rc, Rd, Re are independently selected from hydrogen or lower alkyl; n is 0, 1, 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof.