Patent ID: 6737064
Filing Date: 2004-05-18
Classification: A61K,C07K

Abstract:
A method for the diagnosis of neoplastic tissue, comprising:a) administering to a host having said tissue an effective amount of a conjugate, said conjugate comprising: 1) a delivery vehicle having the ability to localize at the site of neoplastic tissue, and 2) a vasoactive peptide, said peptide comprising a fragment of interleukin-2 containing amino acids 37-58: 33-58: 37-72: or 22-58 of SEQ. ID. NO. 3, wherein said peptide and said fragment are substantially free of cytokine activity, said vasoactive peptide being capable of enhancing vascular permeability when joined to a carrier, said peptide being connected to said delivery vehicle; and b) contemporaneously or thereafter administering to said host a tumor imaging agent.