Patent ID: 6656449
Filing Date: 2003-12-02
Classification: A01K,A61K,C12N,G01N

Abstract:
A method of screening an agent for a pharmacological activity, comprising:(a) providing a multi-well plate, the wells contaning teleosts in a medium and having a volume of 300 microliters or smaller per well; (b) introducing agents into different wells of the multi-well plate, and incubating the agents with the telcosts for sufficient time to induce a response in the teleosts indicative of the pharmacological activity; (c) introducing a labelling reagent into each well, which, through processing by or binding to a component of the teleost, generates a detectable signal dependent on the extent of the response in the teleost; (d) detecting the signal in each well to which an agent was introduced relative to the response from a control well lacking the agent as an indication of the pharmacological activity of the agent introduced in the well.