Patent ID: 6869925
Filing Date: 2005-03-22
Classification: A61K,C07K

Abstract:
1. A method for the inhibition of viral proliferation which comprises treating a patient with a composition containing an antiviral effective amount of a serine protease inhibitor comprising the amino acid sequence set forth in SEQ ID NO:4: R1-Gly-Lys-Ser-Phe-Lys-Ala-Gly-Val-Cys-Pro-Pro- Lys-Lys-Ser-Ala-Gln-Cys-Leu-R2-Tyr-Lys-Lys-Pro- Glu-Cys-Gln-Ser-Asp-Trp-Gln-Cys-Pro-Gly-Lys-Lys- Arg-Cys-Cys-Pro-Asp-Thr-Cys-Gly-Ile-Lys-Cys-Leu- Asp-Pro-Val-Asp-Thr-Pro-Asn-Pro-Thr-Arg-Arg-Lys- Pro-Gly-Lys-Cys-Pro-Val-Thr-Tyr-Gly-Gln-Cys-R8- R3-R9-Asn-Pro-Pro-Asn-Phe-Cys-Glu-R4-Asp-Gly- Gln-Cys-Lys-Arg-Asp-Leu-Lys-Cys-Cys-R5-Gly-R6 Cys-Gly-Lys-Ser-Cys-Val-Ser-Pro-Val-Lys-R7 wherein R1 and R7 are the same or different and are an amino acid residue; R2, R3, R4, R5 and R6 are the same or different and are selected from the group consisting of methionine, valine, alanine, phenylalanine, tyrosine, tryptophan, lysine, glycine and arginine; and R8 and R9 are the same or different and are selected from the group consisting of methionine, valine, alanine, phenylalanine, tyrosine, tryptophan, lysine, glycine, leucine and arginine.