Patent ID: 6569636
Filing Date: 2003-05-27
Classification: C12Q,G01N

Abstract:
A method to determine whether a test compound modulates the enzymatic activity of an enzyme that has an active site comprising a metal, which method comprises:a) providing said test compound coupled to a solid support; b) contacting said test compound coupled to said solid support with the enzyme in metallated form; c) determining as a positive result of b) that the enzyme binds to said test compound coupled to solid support and as a negative result of b) that said enzyme does not bind to said test compound coupled to solid support; d) contacting said test compound coupled to solid support with said enzyme in a nonmetallated form; e) determining as a positive result of d) that the enzyme binds to said test compound coupled to solid support and as a negative result of d) that said enzyme does not bind to said test compound coupled to solid support; f) whereby a positive result in c) and a negative result in e) identifies said test compound as a compound that modulates said enzymatic activity.