Patent ID: 7674605
Filing Date: 2010-03-09
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated monoclonal antibody, which antibody specifically binds to an epitope on the extracellular domain of a human CD43 or a human carcinoembryonic antigen (CEA) expressed by a human colorectal cancer cell, or a human gastric cancer cell, but does not specifically bind to a human CD43 expressed on the cell surface of human peripheral I cells or Jurkat cells, and is capable of inducing apoptosis of the cancer cell after binding to the epitope on the cell surface of the cancer cell in vitro in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate and the binding of the antibody to the epitope is inhibited by oligosaccharides Le a , Le a -lactose, and lacto-N-difucohexaose II (LNDFH II).