Patent ID: 6566381
Filing Date: 2003-05-20
Classification: A61P,C07C,C07D

Abstract:
A compound having a structure according to Formula (I) wherein(A) R3 is selected from the group consisting of hydrogen and alkyl; (B) T is selected from the group consisting of hydrogen and hydroxy; (C) R5 is selected from the group consisting of hydrogen and alkyl; (D) M is â€”Eâ€”(CR19R19â€²)wR20 where (1) w is from O to about 4; (2) E is selected from a â€”Oâ€”; â€”Sxâ€” where x is from O to 2; and â€”NR21â€” where R21 is selected from hydrogen, alkyl, alkenyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, or R21 can join with R20 to form a ring with 5 to 8 members and 1 to 3 heteroatoms; (3) each R19 and R19â€² is hydrogen; (4) R20 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and (E) Z is wherea. Eâ€² and Y are â€”CHâ€”; b. L is â€”C(R35)&boxH;C(R35â€²)â€”, where R35 and R35â€² each is hydrogen; (c) c is 0; (d) Aâ€² is selected from covalent bond, â€”Oâ€” and â€”Sâ€”; and (e) Tâ€² is â€”(CR37R37â€²)eâ€”R38 where c is 0; and R38 is selected from hydrogen, alkyl, alkenyl, alkynyl, halogen, heteroalkyl, haloalkyl, aryl, heteroaryl, cycloalkyl, and hererocycloalkyl; or an optical isomer, diastercomer or enantiomer for Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.