Patent ID: 8580858
Filing Date: 2013-11-12
Classification: A61K,A61P,Y02A

Abstract:
1. A method of treating a patient with a neurological condition, comprising orally administering to a human subject in need thereof: (a) 22.5 to 37.5 mg memantine or a pharmaceutically acceptable salt thereof provided in an extended release dosage form, wherein administration of a dose of said dosage form provides a mean plasma memantine concentration profile characterized by a change in memantine concentration of memantine as a function of time (dC/dT) that is less than about 50% of the dC/dT provided by the same quantity of an immediate release form of memantine, determined in a time period between 0 hours to 6 hours of administration of memantine, and wherein dC/dT is measured in a single-dose human PK study; and (b) a therapeutically effective amount of immediate release donepezil; wherein the neurological condition is selected from Alzheimer's disease, dementia, Parkinson's disease, and neuropathic pain.