Patent ID: 8945619
Filing Date: 2015-02-03
Classification: A61K,A61P

Abstract:
1. A controlled-release oral drug dosage form for releasing a drug, comprising: (a) a core comprising a first polymeric matrix with said drug dispersed therein, and (b) a shell encasing said core, said shell comprising a second polymeric matrix having a drug:polymer weight ratio that is less than that of said core, the second matrix being a material and thickness relative to the core such that when the dosage form is immersed in gastric fluid, the drug is released from the dosage form into the gastric fluid at a controlled rate by diffusion of the drug through the shell during substantially the entire period of drug release such that at least about 40% of said drug remains unreleased one hour after such immersion has begun, said shell remaining intact during substantially the entire period of drug release.