Patent ID: 6890710
Filing Date: 2005-05-10
Classification: A61P,C07K,C12Q,G01N

Abstract:
1. An assay for identifying a substance that inhibits the interaction of an influenza virus nucleoprotein with a host cell protein comprising: (a) contacting an influenza virus nucleoprotein with a host cell protein, under conditions and for a time sufficient to permit the influenza virus nucleoprotein to bind to and form a complex with the host cell protein, in the presence of a test substance, wherein the host cell protein is nucleoprotein interactor (NPI)-1, NPI-2, NPI-3, NPI-4, NPI-5 or NPI-6; and (b) detecting the formation of a complex, wherein a decrease in the complex detected as compared to the amount of complex detected in the absence of the substance indicates that a substance that inhibits the interaction between the influenza virus nucleoprotein and the host cell protein.