Patent ID: 6953865
Filing Date: 2005-10-11
Classification: A61P,C07C

Abstract:
1. A process for the preparation of (R)- or (S)-aminocarnitine inner salt, the salts and a derivatives thereof, said derivative being selected from the group consisting of —NHR, —NHCSR, —NHCOOR, —NHCSOR, —NHCONHR, —NHCSNHR, -NHSOR, —NHSONHR, —NHSO 2 R, —NHSO 2 NHR, wherein R is a C 1 -C 20 saturated or unsaturated, straight or branched alkyl group, optionally substituted with a A 1 group, wherein A 1 is selected from the group consisting of halogen atom, C 6 -C 14 aryl, heteroaryl, aryloxy, heteroaryloxy, groups, being optionally substituted with one or more C 1 -C 20 saturated or unsaturated, straight or branched alkyl or alkoxy group, and/or halogen atom, said process comprising: a) treating (R)- or (S)-nitryloxycarnitine with sodium or potassium phthalimide, then with lithium or sodium azide to give respectively (R)- or (S)-azidocarnitine; b) hydrogenating the (R)- or (S)-azidocarnitine obtained in step a) to give respectively (R)- or (S)-aminocarnitine and, if desired c) salifying the (R)- or (S)-aminocarnitine and, if desired d) transforming the (R)- or (S)-aminocarnitine into one of said derivatives.