Patent ID: 6673769
Filing Date: 2004-01-06
Classification: C07K

Abstract:
Lanthionine-bridged peptides of the formula: wherein R1 is a tetrapeptide selected from the group consisting ofTyr-Phe-Gln-Asn, Phe-D-Trp-Lys-Thr, Phe-D-Trp-Lys-Val, Tyr-lleu-Gln-Asn, and Tyr-D-Trp-Lys-Val; R2 represents en amino acid selected from the group consisting of D-Phe, D-&bgr;-Nal, Tyr, TrpNH2, Thr NH2, Thr(ol), or represents H, acyl or aracyl with 2 to 12 carbon atoms; or an amino acid sequence selected from the group consisting of Pro-Arg-Gly and Pro-u-Gly R3 is selected from the group consisting of â€”OH, NH3; TrpNH2, ThrNH2, Thr(ol), Leu, Arg, where the -C terminal â€”COOH is present or is replaced by â€”CONH2 or â€”CH2OH; and may be replaced by CH2OH; and with the proviso that when R1 is Phe-Trp-Lys-Thr R2 is not Phe and/or R3 is not Thr;R4, R5, R7 and R8 independently represent hydrogen, a methyl group or a C1-10 alkyl group,