Patent ID: 7303739
Filing Date: 2007-12-04
Classification: A61P,C07F,C07H,Y02A

Abstract:
1. A compound of formula I: wherein: V, W, and W′ are independently selected from the group consisting of —H, alkyl, aralkyl, alicyclic aryl, substituted aryl, heteroaryl, substituted heteroaryl, 1-alkenyl, and 1-alkynyl; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group containing 5-7 atoms, optionally 1 heteroatom, substituted with hydroxy, acyloxy, alkoxycarbonyloxy, or aryloxycarbonyloxy attached to a carbon atom that is three atoms from both Y groups attached to the phosphorus; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group, optionally containing 1 heteroatom, said cyclic group is fused to an aryl group at the beta and gamma position to the Y adjacent to V; together V and W are connected via an additional 3 carbon atoms to form an optionally substituted cyclic group containing 6 carbon atoms and substituted with one substituent selected from the group consisting of hydroxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, and aryloxycarbonyloxy, attached to one of said additional carbon atoms that is three atoms from a Y attached to the phosphorus; together Z and W are connected via an additional 3-5 atoms to form a cyclic group, optionally containing one heteroatom, and V is aryl, substituted aryl, heteroaryl or substituted heteroaryl; together W and W′ are connected via an additional 2-5 atoms to form a cyclic group, optionally containing 0-2 heteroatoms, and V is aryl, substituted aryl heteroaryl, or substituted heteroaryl; Z is selected from the group consisting of —CHR p is an integer 2 or 3; with the provisos that: a) V, Z, W, W′ are not all —H; b) when Z is —R c) when Z is CHR d) when V is aryl or substituted aryl, then M is not —O(D) where D is hydrogen, a metal ion or an ammonium ion; R R R R each Y is independently selected from the group consisting of —O—, and —NR M is selected from the group of drugs MH containing an —OH, —NHR or a pharmaceutically acceptable prodrugs or salts thereof.