Patent ID: 6277403
Filing Date: 2001-08-21
Classification: A61K,C09K,Y10T

Abstract:
A process for preparing polymer coated liposomes, the process comprising the steps ofpreparing a suspension of liposomes selected from two-layer liposomes or multilayer liposomes, by extruding a lipid;selecting a liquid crystal polymer and adding the polymer to the suspension of liposomes for providing a polymer coating to the liposomes;wherein the polymer is selected from the group of cholesteric liquid crystals having hydrophobic groups, a rigid mesogene, a cholesteric mesophase and a capability of interacting with the liposomes, consisting ofpoly[oxy(ethyl-1,2-ethanediyl)oxycarbonyl-1,4-phenyleneoxycarbonyl-1,4-phen ylenecarbonyloxy-1,4-phenylenecarbonyl of the formula ##STR3##poly[oxy(decanyl-1,2-ethanediyl)oxycarbonyl-1,4-phenyleneoxycarbonyl-1,4-ph enylenecarbonyloxy-1,4-phenylenecarbonyl] of the formula ##STR4##and mixtures thereof;whereby polymer is added to the suspension of liposomes in a proportion of 10-20%.