Patent ID: 9028818
Filing Date: 2015-05-12
Classification: A61K,A61P,C07K

Abstract:
1. A mixture of at least three antibodies and/or fragments of said antibodies, which bind to three proteins that form adrenomedullin receptors, wherein each antibody and/or antibody fragment binds to a different protein, wherein the three proteins are calcitonin receptor like receptor (CRLR), receptor activity-modifying protein 2 (RAMP2) and receptor activity-modifying protein 3 (RAMP3), and wherein: one of the at least three antibodies and/or fragments of said antibodies binds to an extracellular domain of CRLR and can be obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 1 and SEQ ID No. 2, one of the at least three antibodies and/or fragments of said antibodies binds to an extracellular domain of RAMP2 and can be obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 3 and SEQ ID No. 4, and/or one of the at least three antibodies and/or fragments of said antibodies binds to an extracellular domain of RAMP3 and can be obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 5 and SEQ ID No. 6.