Patent ID: 7666596
Filing Date: 2010-02-23
Classification: C12Q,G01N

Abstract:
1. A method for assessing transplanted tissue for an increased or decreased likelihood of rejection, wherein said method comprises: detecting, from human kidney tissue transplanted into a human, the presence or absence of cells that express guanylate nucleotide binding protein 1 (Gbp1) mRNA or tryptophanyl-tRNA synthetase (Wars) mRNA at an elevated level, wherein said elevated level is at least two times greater than the average level of mRNA expressed in cells from control kidney tissue from a population of humans not rejecting transplanted human kidney tissue, wherein the presence of said cells that express Gbp1 mRNA or Wars mRNA at said elevated level indicates that said human kidney tissue transplanted into a human has an increased likelihood of rejection, and wherein the absence of cells that express Gbp 1 mRNA or Wars mRNA at said elevated level indicates that said human kidney tissue transplanted into a human has a decreased likelihood of rejection.