Patent ID: 6441005
Filing Date: 2002-08-27
Classification: A61P,C07D

Abstract:
A compound of formula 1: wherein:R6 is thioacyl, aminothiocarbonyl, alkoxythiocarbonyl, alkylthio(carbonyl), or alkylthio(thiocarbonyl); R7 is aryl or monocyclic heteroaryl; R8 is C4-C7 alkyl, C2-C7 alkynyl, O, OC(&boxH;O), OC(&boxH;O)NR, NRC(&boxH;O)O, C(&boxH;S)NR, NRC(&boxH;S), C(&boxH;S), C(&boxH;S)O, OC(&boxH;S), OC(&boxH;S)NR, NRC(&boxH;S)O, NRCONRâ€², NRC(&boxH;S)NRâ€², or (CH2)nO, wherein n=2-6, and wherein R and Râ€² are independently H, alkyl, heteroalkyl, aryl or heteroaryl; and R9 is hydrogen, OH, ORâ€³, SRâ€³, NRâ€³Râ€²â€³, alkyl, aryl, heteroalkyl, or heteroaryl, and wherein Râ€³ and Râ€²â€³ are independently H, alkyl, heteroalkyl, aryl or heteroaryl, with the proviso that when R7 is aryl, R6 is different from alkylthio(carbonyl).