Patent ID: 6248719
Filing Date: 2001-06-19
Classification: A61P,C07H

Abstract:
A compound of the formula ##STR8##on pharmaceutically acceptable salts thereof, wherein:R.sup.1 is selected from H the group consisting of --(CR.sup.4 R.sup.5).sub.m R.sup.6, --C(O)(CR.sup.4 R.sup.5).sub.m R.sup.6, --C(O)O(CR.sup.4 R.sup.6).sub.m R.sup.6, and --C(O)NR.sup.4 (CR4R.sup.5).sub.m R.sup.6, wherein m is an integer ranging from 0 to 6 and both R.sup.4 and R.sup.5 may vary for each iteration where m is greater than 1;each R.sup.2 and R.sup.3 are independently selected from the group consisting of H and C.sub.1 -C.sub.18 alkyl, wherein one or two carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N, and are optionally substituted by 1 to 3 substituents independently selected from the group consisting of --C(O)O(C.sub.1 -C.sub.10)alkyl, --O(C.sub.1 -C.sub.10)alkyl, C.sub.1 -C.sub.10 alkanoyl, halo, nitro, cyano, C.sub.1 -C.sub.10 alkyl, 4-10 membered heterocyclic, C.sub.6 -C.sub.10 aryl, --NH(C.sub.1 -C.sub.10)alkyl, --S(C.sub.1 -C.sub.10 alkyl), --SO(C.sub.1 -C.sub.10)alkyl, --SO.sub.2 (C.sub.1 -C.sub.10)alkyl and --SO.sub.2 N(C.sub.1 -C.sub.10)alkyl, provided that two O atoms, two S atoms or an S and an O atom are not bonded to each other;each R.sup.4 and R.sup.5 are independently selected from the group consisting of H, halo and C.sub.1 -C.sub.6 alkyl, wherein 1 to 3 carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N and each R.sup.4 and R.sup.5 may vary independently when m is greater than 1, provided that two O atoms, two S atoms or an S and an O atom are not bonded to each other; oreach R.sup.4 and R.sup.5 taken together with the carbon to which they are attached can form a 3-10 membered ring, wherein one or more carbons of said ring are optionally replaced by a heteroatom selected from the group consisting of O, S and N, and are optionally substituted by 1 to 3 substituents independently selected from the group consisting of --C(O)O(C.sub.1 -C.sub.10)alkyl, --O(C.sub.1 -C.sub.10)alkyl, C.sub.1 -C.sub.10 alkanoyl, halo, nitro, cyano, C.sub.1 -C.sub.10 alkyl, 4-10 membered heterocyclic, C.sub.6 -C.sub.10 aryl, --NH(C.sub.1 -C.sub.10)alkyl, --N((C.sub.1 -C.sub.10)alkyl).sub.2, --S(C.sub.1 -C.sub.10)alkyl, --SO(C.sub.1 -C.sub.10)alkyl, --SO.sub.2 (C.sub.2 (C.sub.1 -C.sub.10)alkyl and --SO.sub.2 N(C.sub.1 -C.sub.10)alkyl, provided that two O atoms, two S atoms or an S and an O atom are not bonded to each other;R.sup.6 is (C.sub.1 -C.sub.18)alkyl, a 4-10 membered heterocyclic or C.sub.6 -C.sub.10 aryl, wherein 1 to 3 carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N and said heterocycic and aryl groups are optionally substituted by 1 to 3 substituents independently selected from the group consisting of --C(O)O(C.sub.1 -C.sub.10)alkyl, --O(C.sub.1 -C.sub.10)alkyl, C.sub.1 -C.sub.10 alkanoyl, halo, nitro, cyano, (C.sub.1 -C.sub.10) alkyl, --NH(C.sub.1 -C.sub.10)alkyl, --N((C.sub.1 -C.sub.10)alkyl).sub.2, --S(C.sub.1 -C.sub.10 alkyl), --SO(C.sub.1 -C.sub.10)alkyl, --SO.sub.2 (C.sub.1 -C.sub.10)alkyl and --SO.sub.2 N(C.sub.1 -C.sub.10)alkyl, provided that two O atoms, two S atoms or an S and an O atom are not bonded to each other; andR.sup.7 is H, --C(O)O(C.sub.1 -C.sub.18)alkyl or --C(O)(C.sub.1 -C.sub.18)alkyl, wherein 1 to 3 carbons of said alkyl are optionally replaced by a heteroatom selected from the group consisting of O, S and N and wherein in the alkyl portion of said alkanoyl one or two carbons optionally may be replaced by a heteroatom selected from O, S and N, provided that two O atoms, two S atoms or an S and an O atom are not bonded to each other.