Patent ID: 9084841
Filing Date: 2015-07-21
Classification: A61K,A61L,A61P

Abstract:
1. A method of treating atrial fibrillation in a subject, comprising: providing an extracellular matrix (ECM) composition comprising ECM from a mammalian tissue source comprising acellular basement membrane, said ECM composition further comprising a statin and an exogenously added growth factor comprising transforming growth factor-β (TGF-β), said statin and growth factor being linked to said ECM, wherein, when said ECM composition is administered to damaged myocardium tissue of said subject, said statin and growth factor interact with said ECM to modulate inflammation of said myocardium tissue and induce remodeling of cardiac tissue, whereby said ECM composition modulates electrical activity in the heart of said subject; and delivering said ECM composition directly to said damaged myocardium tissue of said subject, wherein said ECM composition reduces incidence of atrial fibrillation.