Patent ID: 6172095
Filing Date: 2001-01-09
Classification: A61K,C07D

Abstract:
A compound of formula; ##STR13##wherein;a) R.sub.1 is hydrogen; or alkyl or nil; where R.sub.1 is nil, bond (.alpha.) is a double bond;b) D is CR.sub.2 where R.sub.2 is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl; amino, hydroxy, mercapto; C.sub.1 -C.sub.3 alkylthio or alkoxy; C.sub.1 -C.sub.3 alkylamino;c) B is NR.sub.9 wherein R.sub.9 is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, and cycloalkenyl;d) R.sub.4, R.sub.5 and R.sub.6 are each independently selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino; halo; and NH--NH--C(--NR.sub.10)NHR.sub.11 (guanidinylamino); wherein R.sub.10 and R.sub.11 are independently selected from hydrogen; methyl; and ethyl; and wherein one and only one of R.sub.4, R.sub.5 and R.sub.6 is guanidinylamino;e) R.sub.7 is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl, unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C.sub.1 -C.sub.3 alkylamino or C.sub.1 -C.sub.3 dialkylamino and halo;or an enantiomer, optical isomer, stereoisomer, diastereomer, tautomer, addition salt, biohydrolyzable amide and ester thereof.