Patent ID: 7901677
Filing Date: 2011-03-08
Classification: A61P,C07K

Abstract:
1. A method for treating B-cell chronic lymphocytic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, lung cancer, colon carcinoma, mammary carcinoma, pancreatic carcinoma, prostate cancer, or metastasising cancers, comprising administering to a patient in need thereof a pharmaceutical composition comprising a tandem diabody, wherein said tandem diabody is prepared by non-covalent dimerization of single-chain Fv-antibodies each comprising a V H and a V L specific to an epitope of 67 kDa laminin receptor or its 37 kDa precursor and separated by a peptide linker or by no linker, said V H comprises the amino acid sequence of SEQ ID NO: 4 or 6.