Patent ID: 8957187
Filing Date: 2015-02-17
Classification: A61P,C07K,G01N

Abstract:
1. A polypeptide that binds to human DR5, the polypeptide comprising an immunoglobulin heavy chain variable domain, and an immunoglobulin light chain variable domain, wherein, in the heavy chain variable domain: (i) CDRH1 comprises an amino acid sequence GFYISSSSIH (SEQ ID NO:531); (ii) CDRH2 comprises an amino acid sequence SISPSSGSTYYADSVKG (SEQ ID NO:548); and (iii) CDRH3 comprises an amino acid sequence YRSYRYGSYYGSYGFDY (SEQ ID NO:565); and in the light chain variable domain: (iv) CDRL1 comprises an amino acid sequence RASQDVNTAVA (SEQ ID NO:29); (v) CDRL2 comprises an amino acid sequence SASSLYS (SEQ ID NO:30); and (vi) CDRL3 comprises an amino acid sequence QQYYYSPST (SEQ ID NO:514).