Patent ID: 9005900
Filing Date: 2015-04-14
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of identifying a breast cancer that will respond favorably to a chemotherapy treatment that includes a taxane or taxane derivative, the method comprising: (a) performing immunohistochemical staining for TLE3 polypeptide on a cancer sample obtained from a breast cancer patient, wherein the breast cancer patient is triple negative for estrogen receptor, progesterone receptor, and HER-2 markers; (b) detecting a percentage and/or intensity of immunohistochemical staining for TLE3 polypeptide in the cancer sample, wherein the detected percentage and/or intensity is higher than a reference; and (c) identifying the patient's breast cancer as one that will respond favorably to a chemotherapy treatment that includes a taxane or taxane derivative, wherein the step of performing immunohistochemical staining comprises contacting the cancer sample with an antibody that binds TLE3 polypeptide thereby forming a complex comprising the antibody and TLE3 polypeptide, and the step of detecting comprises detecting the complex in the cancer sample.