Patent ID: 6603011
Filing Date: 2003-08-05
Classification: A61P,C07D

Abstract:
A compound having the formula: wherein X is selected from the group consisting of Câ€”H, Câ€”F, Câ€”Cl , Câ€”Br, Câ€”I, Câ€”NRâ€²Râ€³, Câ€”CF3, Câ€”CN, Câ€”C2Râ€², Câ€”SCH3, Câ€”N3, Câ€”SO2CH3, Câ€”ORâ€², Câ€”SRâ€², Câ€”C(&boxH;O)NRâ€²Râ€³, Câ€”NRâ€²C(&boxH;O)Râ€², Câ€”(C&boxH;O)Râ€², Câ€”C(&boxH;O)ORâ€², Câ€”CH2Râ€², Câ€”OC(&boxH;O)Râ€², Câ€”OC(&boxH;O)NRâ€²Râ€³ and Câ€”NRâ€²C(&boxH;O)ORâ€² where Râ€²and Râ€³ are individually hydrogen or C1-5 alkyl, n is 2, 3, 4, 5, 6, or 7, Zâ€² and Zâ€³ individually represent hydrogen or C1-5 alkyl, at least one of Zâ€² or Zâ€³ is C1-5 alkyl; A, Aâ€² and Aâ€³ individually represent hydrogen or C1-5 alkyl or halo C1-5 alkyl; Eâ€² and Eâ€³ individually represent H, C1-5 alkyl or halo C1-5 alkyl; and at least one Eâ€² at the alpha position to the NZâ€²Zâ€³ group represents C1-5 alkyl.