Patent ID: 8658790
Filing Date: 2014-02-25
Classification: A61P,C07D,Y02P

Abstract:
1. A process for the stereoselective preparation of the compound of formula (1B) optionally in the form of the tautomers thereof, and optionally the pharmacologically acceptable acid addition salts thereof, comprising (A) reaction of 1,4-cyclohexanedione-mono-ethyleneketal to form a compound of formula (1) (B) reaction of the compound of formula (1) to form a compound of formula (2) (Z) reaction of the compound of formula (2) to form a compound of formula (16) (H) reaction of the compound of formula (16) to form a compound of formula (6) (P) reaction of the compound of formula (6) with a compound of formula (23) to form a compound of formula (7) (Q+M) cleavage of the protective groups from the compound of formula (7) to form a compound of formula (12) (N) chlorination of the compound of formula (12) to form a compound of formula (13) and (O) reaction of the compound of formula (13) with 3-chloro-2-fluoroaniline to form the compound of formula (1B), wherein the protective group Sg the protective group Sg the protective group Sg