Patent ID: 8877171
Filing Date: 2014-11-04
Classification: A61K,A61P,C07C,C07D,C07H,C08G

Abstract:
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a conjugate of a sulfated polyol and a therapeutic effector molecule suitable for treating a disease selected from the group consisting of cancer, inflammation, autoimmune disease and fibrosis of the following formula wherein P is a polyol macromolecule wherein a number n of the hydroxyl groups of the polyol macromolecule is substituted by sulfate groups OSO n is a number >10, M is a cationic inorganic or organic counter ion to the anionic sulfate group, E is a therapeutic effector molecule suitable for treating a disease selected from the group consisting of cancer, inflammation, autoimmune disease and fibrosis, L is a linker or spacer between P and E, G is a reactive group suitable for the covalent attachment between L and E, and m is a number of from 1 to 100.