Patent ID: 6726881
Filing Date: 2004-04-27
Classification: G01N

Abstract:
A measurement chip for a surface plasmon resonance biosensor, which comprises a transparent substrate, a metal membrane located on the transparent substrate and an organic silicon membrane immobilized on the metal membrane via a functional group capable of binding with atoms on the surface of a metal, and wherein a bifunctional reagent, which contain a functional group capable of binding with physiologically active compound, is further bound to the organic silicon membrane, said bifunctional reagent is a disulfone compound, represented by the following formula:X1â€”SO2-L2â€”SO2â€”X2, wherein X1 and X2 independently represent â€”CR1&boxH;CR2R3 or â€”CHR1â€”CR2R3Y; CR1&boxH;CR2R3 independently represent an atom or a group selected from the group consisting of a hydrogen atom, an alkyl group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 20, and an aralkyl group which contains an alkyl chain having a carbon number of 1 to 6 and has a total carbon number of 7 to 26; Y represents an atom or a group selected from the group consisting of a halogen atom, â€”OSO2R11, â€”OSO2R12, â€”OSO3M and a quaternary group consisting of a halogen atom, â€”OSO2R11, â€”OSO2R12, â€”OSO3M and a quaternary pyridinium group; R11 represents a group selected from the group consisting of an alkyl group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 20, and an aralkyl group which contains an alkyl chain having a carbon number of 1 to 6 and has a total carbon number of 7 to 26; R12 represents a group selected from the group consisting of an alkyl group having a carbon number of 1 to 6 and a halogenated alkyl group having a carbon number of 1 to 6; M represents an atom or a group selected from the group consisting of a hydrogen atom, an alkali metal atom and an ammonium group; and L2 represents a linking group.