Patent ID: 7371551
Filing Date: 2008-05-13
Classification: C12N,C12P

Abstract:
1. A homoserine transsuccinylase which possesses at least one mutation as compared with a homoserine transsuccinylase wild-type enzyme and exhibits a reduced sensitivity toward L-methionine or SAM as compared with the wild-type enzyme, with the wild-type enzyme possessing an amino acid sequence of SEQ ID NO: 2 which comprises a constituent sequence AspGlyXaaXaaXaaThrGlyAlaPro between positions 90 and 115 and a constituent sequence TyrGlnXaaThrPro between positions 285 and 310, with position 1 of the amino acid sequence being the starting methionine, wherein the mutation is an amino acid replacement of the aspartate in the constituent sequence AspGlyXaaXaaXaaThrGlyAlaPro or an amino acid replacement of the tyrosine in the constituent sequence TyrGlnXaaThrPro.