Patent ID: 6228861
Filing Date: 2001-05-08
Classification: A61P,C07D

Abstract:
A compound having the structure: ##STR23##where M has the structure ##STR24##wherein each of Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4 and Y.sub.5 independently may be --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl; --F, --Cl, --Br, or --I; --NO.sub.2 ; --N(R.sub.3).sub.2 ; --N.sub.3 ; --CN; --OR.sub.3 ; --OCOR.sub.3 ; --COR.sub.3 ; --CON(R.sub.3).sub.2 ; or --CO.sub.2 R.sub.3 ; or wherein two of Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4 and Y.sub.5 are present on adjacent carbon atoms and together constitute a methylenedioxy group;where R independently may be --H; --F; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; --N(R.sub.3).sub.2 ; NO.sub.2 ; --CN; --CO.sub.2 R.sub.3 ; --(CH.sub.2).sub.p PO(OR.sub.3).sub.2 ; --(CH.sub.2).sub.p PO(OR.sub.3).sub.3 ; or OR.sub.3 ;where R.sub.1 may be --H; --NO.sub.2 ; --CN; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl; --N(R.sub.3).sub.2 ; --OR.sub.3 ; --(CH.sub.2).sub.p OR.sub.3 ; --COR.sub.3 ; --CO.sub.2 R.sub.3 ; or --CON (R.sub.3).sub.2 ;wherein any p independently is an integer from 1 to 7 inclusive;where R.sub.2 may be --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl; C.sub.3 -C.sub.10 cycloalkyl-C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 cycloalkyl-C.sub.1 -C.sub.10 -monofluoroalkyl or C.sub.3 -C.sub.10 cycloalkyl-C.sub.1 -C.sub.10 -polyfluoroalkyl; --CN; --CH.sub.2 XR.sub.3, --CH.sub.2 X(CH.sub.2).sub.p NHR.sub.3, --(CH.sub.2).sub.n NHR.sub.3, --CH.sub.2 X(CH.sub.2).sub.p N(R.sub.3).sub.2, --CH.sub.2 X(CH.sub.2).sub.p N.sub.3, or --CH.sub.2 X(CH.sub.2).sub.p NHCXR.sub.7 ; or --OR.sub.3 ;wherein any n independently is an integer from 0 to 5 inclusive and p is as defined above;where each R.sub.3 independently may be --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl; --(CH.sub.2).sub.p PO(OR.sub.8).sub.2 ; --(CH.sub.2).sub.p PO(OR).sub.3 ; or --(CH.sub.2).sub.p COOR.sub.8 ;where R.sub.4 has the structure ##STR25##wherein Z may be C.sub.2 -C.sub.7 alkenyl or alkynyl; CH.sub.2 ; O; CO; CO.sub.2 ; CONR.sub.3 CO; CONR.sub.3 ; S; SO; SO.sub.2 ; or NR.sub.3 ; m is an integer from 0 to 3 inclusive;R.sub.5 and R.sub.6 each independently may be --H; --; --Cl; --Br; --I; --CO.sub.2 R.sub.3 ; --COR.sub.3 ; --CON(R.sub.3).sub.2 ; --CN; --NO.sub.2 ; --N(R.sub.3).sub.2 ; --OR.sub.3 ; straight chained or branched C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 monofluoroalkyl, C.sub.1 -C.sub.7 polyfluoroalkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, or C.sub.3 -C.sub.7 cycloalkenyl; wherein the alkyl, monofluoroalkyl, polyfluoroalkyl, alkenyl, alkynyl, cycloalkyl, or cycloalkenyl may be unsubstituted or substituted with --H, aryl, or heteroaryl; aryl or heteroaryl wherein the aryl or heteroaryl may be unsubstituted or substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, --N(R.sub.3).sub.2, --OR.sub.3, --COR.sub.3, --CO.sub.2 R.sub.3, or --CON(R.sub.3).sub.2 ; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl;R.sub.7 may be --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, monofluoroalkyl, or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl, or cycloalkenyl; --CN; --CO.sub.2 R.sub.3 ; --COR.sub.3 ; --CON(R.sub.3).sub.2 ; or --OR.sub.3 ;where R.sub.8 is --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl;where R.sub.9 may be --H; --CN; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or cycloalkenyl; --N(R.sub.3).sub.2 ; --OR.sub.3 ; --(CH.sub.2).sub.p OR.sub.3 ; --COR.sub.3 ; --CO.sub.2 R.sub.3 ; or --CON(R.sub.3).sub.2 ;where X may be S; O; or NR.sub.3 ; andwhere B may be --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl, polyfluoroalkyl, alkoxy or thioalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl; --SCH.sub.2 C.sub.6 H.sub.4 OR.sub.3 ; --(CH.sub.2).sub.n C.sub.6 H.sub.5 ; --CH.sub.2 X(CH.sub.2).sub.n NHR.sub.3 ; --(CH.sub.2) .sub.n NHR.sub.3 ; or --OR.sub.3 ;or a pharmaceutically acceptable salt thereof.