Patent ID: 6242564
Filing Date: 2001-06-05
Classification: A61K,C07K,C12N

Abstract:
A method of treating tropical spastic paresis in mammals which comprises administering an effective amount of a peptide of the formula (I):R.sup.a -Ser-Thr-Thr-Thr-Asn-Tyr-R.sup.b (I)where R.sup.a represents an amino terminal residue Ala-, D-Ala- or Cys-Ala- and R.sup.b represents a carboxy terminal residue -Thr, -Thr-amide, -Thr-Cys or Thr-Cys-amide; or a peptide of formula (II):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 (II)whereR.sup.1 is an amino acid terminal residue XR.sup.6 or R.sup.6 wherein R.sup.6 is Thr-, Ser-, Asn-, Leu-, Ile-, Arg-, or Glu- and X is Cys,R.sup.2 is Thr, Ser, or Asp,R.sup.3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp,R.sup.4 is Tyr,and R.sup.5 is a carboxy terminal residue which is R.sup.7 X or R.sup.7 wherein R.sup.7 is Thr, Arg or Gly and X is Cys or a physiologically acceptable salt thereof.