Patent ID: 6310207
Filing Date: 2001-10-30
Classification: C07D,Y02P

Abstract:
A process of preparing a compound of formula 1, or a salt thereof, ##STR4##the process comprising:(a) reacting a compound of formula 2 ##STR5##whereinY and Z are independently chosen from --H, a C.sub.1 to C.sub.6 alkyl group, a C.sub.1 to C.sub.3 hydroxyalkyl group, and an amine protecting group;R.sub.1 is selected from --H, a C.sub.1 to C.sub.6 alkyl group and a hydroxy group;R.sub.2 and R.sub.3 are independently selected from --H and hydroxy, or taken together form a methylenedioxy or ethylenedioxy group;R.sub.4 is selected from --H and a C.sub.1 to C.sub.6 alkyl group; andR.sub.5 is selected from --H, hydroxy, halogen and amine with an amine, or salt thereof, and a source of formaldehyde in the presence of an acid; and(b) obtaining a compound of formula 1, or a salt thereof.