Patent ID: 8304553
Filing Date: 2012-11-06
Classification: C07C,C07D,Y02P

Abstract:
1. A process of forming a 4,5-diamino cyclohexene carboxylate ester of general formula (1) or a pharmaceutically acceptable salt thereof, wherein R wherein R the process comprising: (a) reacting a 3,4-dihydropyran compound (9) wherein R (b) oxidizing aldehyde (4) to carboxylic acid ester (10) (c) replacing protecting group R wherein R (d) reacting N-substituted carbamate (3) to form oxazolinidone (12) (e) removing moiety OR wherein R (f) reacting oxazolinidone (13) to form azido carboxylate ester (2) wherein R (g) converting azido carboxylate ester (2) to 4,5-diamino cyclohexene carboxylate ester (1).