Patent ID: 7514397
Filing Date: 2009-04-07
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A method for the inhibition of transmission of a hepatitis B virus to a cell, comprising contacting the virus, in the presence of the cell, with an effective concentration of a peptide having the formula: X-PLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSP-Z; X-PLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGT-Z; X-LLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTT-Z; X-LVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTV-Z; X-LQAGFFLLTRILTIPQSLDSWWTSLNGLGGTTVCL-Z; X-QAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLG-Z; X-AGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQ-Z; X-GFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQN-Z; X-FFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNS-Z; X-FLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQ-Z; X-LLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQS-Z; X-PGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLEPGSSTTSTGPCRTCMTT-Z, X-PGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGML-Z; X-GYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLP-Z X-YRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVC-Z; X-RWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVC-Z; X-WMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCP-Z; X-MCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPI-Z; X-CLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLI-Z; X-LRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIP-Z; X-RRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPG-Z; X-RFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGS-Z; X-FIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSS-Z; IIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSST-Z X-IFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTT-Z: X-FLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTS-Z: X-LFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTST-Z: X-FILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTG-Z; X-ILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGP-Z: X-LLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPC-Z; X-LLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCR-Z; X-LCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRT-Z; X-CLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTC-Z; X-LIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCM-Z; or X-IFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMT-Z; in which: