Patent ID: 6420383
Filing Date: 2002-07-16
Classification: A61P,C07D

Abstract:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein(a) R1, R2, R3, R4 and R5 are independently selected from H, OH, halogen, cyano, NO2, alkyl, C1-8 alkoxy, C1-8 alkylsulfonyl, C1-4 carboalkoxy, C1-8 alkylthio, difluoromethoxy, difluoromethylthio, trifluoromethyl, and oxadiazole (formed by R1 and R2); (b) R6 is selected from H, C1-5 straight or branched alkyl, substituted alkyl, aryl, 3-piperidyl, N-substituted 3-piperidyl, and N-substituted 2-pyrrolidinyl methylene, wherein said N-substituted 3-piperidyl and said N-substituted 2-pyrrolidinyl methylene may be substituted with C1-8 straight or branched chain alkyl or benzyl, and said substituted alkyl may be substituted with C1-8 alkoxy, C2-8 alkanoyloxy, phenylacetyloxy, benzoyloxy, hydroxy, halogen, p-tosyloxy, mesyloxy, amino, carboalkoxy or NRâ€²Râ€³, wherein (i) Râ€² and Râ€³ are independently selected from the group consisting of H, C1-8 straight or branched alkyl, C3-7 cycloalkyl, phenyl, benzyl, and phenethyl, or (ii) Râ€² and Râ€³ together form a heterocyclic ring selected from the group consisting of piperidino, pyrrolidino, morpholino, thiomorpholino, piperazino, 2-thieno, 3-thieno, and an N-substituted derivative of said heterocyclic rings, said N-substituted derivative being substituted with H, C1-8 straight or branched alkyl, benzyl, benzhydryl, phenyl and/or substituted phenyl (substituted with NO2, halogen, C1-8 straight or branched chain alkyl, C1-8 alkoxy and/or trifluoromethyl); (c) R7 is selected from aryl, 3-pyridyl, 2-thieno, and 3-thieno; and (d) n is an integer from 1 to 5.