Patent ID: 6200796
Filing Date: 2001-03-13
Classification: A61K,C12N,C12Q

Abstract:
An isolated polynucleotide comprising a nucleotide sequence which is a member selected from the group consisting of:(a) a nucleotide sequence encoding a fragment of the polypeptide of SEQ ID NO:2, wherein said fragment retains biological activity of said polypeptide;(b) a nucleotide sequence encoding a polypeptide which is a variant of the polypeptide of SEQ ID NO:2 or of (a), resulting from conservative amino acid substitution;(c) a nucleotide sequence encoding a polypeptide having at least 95% identity to the polypeptide of (a) or (b);(d) a nucleotide sequence encoding a polypeptide of at least 30 contiguous amino acids of SEQ ID NO:2;(e) a nucleotide sequence encoding a polypeptide of at least 50 contiguous amino acids of SEQ ID NO:2;(f) a nucleotide sequence which hybridizes to the complement of the nucleotide sequence of residues 10 to 1743 of SEQ ID NO: 1, wherein said nucleotide sequence encodes a polypeptide that retains biological activity of the polypeptide of SEQ ID NO:2;(g) a nucleotide sequence encoding an antigenic peptide fragment of the polypeptide of (a), (b), (c), (d), (e), or (f); and(h) a nucleotide sequence that is the complement of the nucleotide sequence of (a), (b), (c), (d), (e), (f), or (g).