Patent ID: 6225325
Filing Date: 2001-05-01
Classification: A61K,A61P,C07D

Abstract:
A method for preventing, reducing, or reversing multidrug resistance in a patient undergoing treatment with a chemotherapeutic agent, comprising administering to said patient an anti-multidrug resistance effective amount of an N-substituted-1,5-dideoxy-1,5-imino-D-glucitol or galactitol compound of Formula I: ##STR3##wherein R is selected from the group consisting of arylalkyl, cycloalkylalkyl, and branched or straight chain alkyl having a chain length of C.sub.2 to C.sub.20, andW, X, Y and Z are independently selected from the group consisting of hydrogen, alkanoyl, aroyl, and trifluoroalkanoyl, ora pharmaceutically acceptable salt thereof,for a period of time effective to prevent, reduce, or reverse multidrug resistance in cancer cells of said patient.