Patent ID: 7449572
Filing Date: 2008-11-11
Classification: A61K,A61P,C07J

Abstract:
1. A process for preparing compounds of formula (I): wherein R R X is halogen; R n is an integer from 2 to 8, comprising the steps of: a) subjecting a compound of formula (II): wherein ═K is a protected keto functional group selected from ketal, thioketal or a mixed ketal, to the action of an agent for reducing the keto in the 17-position in order to obtain a compound of formula (III): b) treating the compound of formula (III) with a halogenating agent in order to obtain a compound of formula (IV): wherein X is halogen; c) subjecting the compound of formula (IV) to the action of an epoxidation reagent in order to obtain the compound of formula (V): d) subjecting the compound of formula (V) to an alkylation reaction with an organocuprate derivative derived from an organometallic compound of formula R wherein n, R 1 and R 2 are as defined above, the bonding taking place at the level of the phenyl, and then to the action of a deprotecting agent in order to obtain the compound of formula (VI): e) treating the compound of formula (VI) with an aromatization agent in order to obtain the compound of formula (I); f) deprotecting, optionally, the product obtained in stage e to obtain a compound of formula (I), wherein R