Patent ID: 8563537
Filing Date: 2013-10-22
Classification: A61K,A61P,C07D

Abstract:
1. A method of sensitizing tumor cells to radiation, which method comprises a) administering to said cells a camptothecin-based compound comprising one or more radiosensitizing electron-affinic groups, wherein the electron-affinic groups are selected from the group consisting of (+)-2-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy)-propionic acid (TAPA), (−)-2-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy)-propionic acid (TAPA) and 2-(2,4,5,7-tetranito-9-flourenylidenaminooxy)-ethanoic acid (TNF-ethanoic acid).