Patent ID: 6451983
Filing Date: 2002-09-17
Classification: A61K,C07K

Abstract:
An isolated antibody or fragment thereof that binds to mature human TNF-&agr;,wherein the antibody or fragment thereof is characterized in that when the antibody or fragment thereof binds TNF-&agr; the induction of tumorfibrin deposition is unaffected; the induction of endothelial procoagulant activity, cytotoxicity, tumor regression and tumor receptor binding are inhibited; and, wherein the antibody or fragment thereof binds to TNF-&agr; such that the epitope defined by the topographic regions Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37 -Ala38-Asn39-Gly40, Cys69-Pro70-Ser71-Thr72-His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala-84-Val85-Ser86-Tyr87 -Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94-Ser95-Ala96-Ile97, Thr105-Pro106-Glu107-Gly108-Ala109-Glu110-Ala111-Lys112 -Pro113-Trp114-Tyr115-Glu116-Pro117-Ile118-Tyr119-Leu120-Gly121-Gly122-Val123-Phe124-Gln125-Leu126 -Glu127-Lys128, and Glu135-Ile136-Asn137-Arg138-Pro139-Asp140-Tyr141-Leu142-Asp143-Phe144-Ala145 -Glu146-Ser147-Gly148-Gln149-Val150-Tyr151-Phe152-Gly153-Ile154-Ile155is prevented from binding to mature human TNF-&agr; receptor.