Patent ID: 6265381
Filing Date: 2001-07-24
Classification: A61K,C07K

Abstract:
A compound of the formulaK--B--P.sub.4 --P.sub.3 --P.sub.2 --P.sub.1 --CF.sub.2 CF.sub.3 1 (SID NO. 1)whereinP.sub.1 is Ala, bAla, Leu, Ile, Val, Nva, bVal, Met, Nle, or an N-methyl derivative;P.sub.2 is Ala, bAla, Leu, Ile, Val, Nva, bVal, Met, Nle, Gly, Phe, Tyr, Trp, or Nal(1) where the nitrogen of the alpha-amino group can be substituted with an R group where R is a (C.sub.1-6)alkyl, (C.sub.3-12)cycloalkyl, (C.sub.3-12)cycloalkyl(C.sub.1-6)alkyl, (C.sub.4-11)bicycloalkyl, (C.sub.4-11)bicycloalkyl(C.sub.1-6)alkyl, (C.sub.6-10)aryl, (C.sub.6-10)aryl(C.sub.1-6)alkyl, (C.sub.3-7)heterocycloalkyl, (C.sub.3-7)heterocycloalkyl(C.sub.1-6)alkyl, (C.sub.5-9 g)heteroaryl, (C.sub.5-9)heteroaryl(C.sub.1-6)alkyl, fused (C.sub.6-10)aryl(C.sub.3-12)cycloalkyl, fused (C.sub.6-10)aryl(C.sub.3-12)cycloalkyl(C.sub.1-6)alkyl, fused (C.sub.5-9)heteroaryl(C.sub.3-12)cycloalkyl, or fused (C.sub.5-9)heteroaryl(C.sub.3-12)cycloalkyl(C.sub.1-6)alkyl, or P.sub.2 is Pro, 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid (Tic), thiazolidine-4-carboxylic acid (Tca), or Ind;P.sub.3 is Ala, bAla, Leu, Ile, Val, Nva, bVal, Met, or Nle or an N-methyl derivative, Pro, Ind, Tic or Tca, Lys or Orn each substituted on its omega amino group with a morpholino-B-group;P.sub.4 is Ala, bAla, Leu, Ile, Val, Nva, bVal, Met, or Nle or an N-methyl derivative or a bond;B is a group of the formulae ##STR53##