Patent ID: 6159969
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A uracil derivative represented by the following formula (1'): ##STR171## wherein R.sup.1 is selected from the group consisting of chlorine, bromine, iodine, cyano and a lower alkyl group; and R.sup.2 represents an amidinothio group, one or more of the hydrogen atom(s) on one or both of the nitrogen atoms of which may each be substituted by a lower alkyl group; a guanidino group, one or more of the hydrogen atom(s) on one, two or all of the nitrogen atoms of which may each be substituted by a lower alkyl or cyan group; a (lower alkyl) amidino group; a group --CH.sub.2 N(R.sup.a)R.sup.b in which R.sup.a and R.sup.b may be the same or different and each represents a hydrogen atom or a lower alkyl group or R.sup.a and R.sup.b may form a pyrrolidine ring together with the nitrogen atom to which R.sup.a and R.sup.b are bonded; a group --NH--(CH.sub.2).sub.m --Z in which Z represents an amino group, one or both of the hydrogen atoms on the nitrogen atom of which may each be substituted by a lower alkyl group or a cyano group, and m stands for an integer of from 0 to 3; a group NR.sup.c (CH.sub.2).sub.n --OH in which R.sup.c represents a hydrogen atom or a lower alkyl group, and n stands for a natural number of from 1 to 4; a group --X--Y in which X represents S or NH, and Y represents a 2-imidazolin-2-yl, 2-imidazolyl, 1-methylimidazol-2-yl, 1,2,4-triazol-3-yl, 2-pyrimidyl or 2-benzimidazolyl group which may be substituted by one or more lower alkyl groups; or a ureido or thioureido group, one or more of the hydrogen atom(s) on one or both of the nitrogen atoms of which may each be substituted by a lower alkyl group, with the proviso that R.sup.1 and R.sup.2 are not a bromine atom and an amino group, respectively, at the same time; or a salt thereof.