Patent ID: 6573246
Filing Date: 2003-06-03
Classification: A61P,C07H

Abstract:
An etherlipid having the formula: wherein:R1 is a group having the formula â€”Y1Y2; Y1 is a group having the formula â€”(CH2)n1(CH&boxH;CH)n2(CH2)n3(CH&boxH;CH)n4(CH2)n5(CH&boxH;CH)n6(CH2)n7(CH&boxH;CH)n8(CH2)n9 and the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer of from 3 to 23, n1 is equal to zero or an integer of from 1 to 23, n3 is equal to zero or an integer of from 1 to 20, n5 is equal to zero or an integer of from 1 to 17, n7 is equal to zero or an integer of from 1 to 14, n9 is equal to zero or an integer of from 1 to 11, and each of n2, n4, n6 and n8 is independently zero or 1; Y2 is CH3, CO2H or OH; R2 is O, S, NH, â€”OC(O)â€” or NHCO; R3 is a group having the formula wherein:X1 is O or S; X2 is H, OH, NH2, NHCH3, N(CH3)2, OCH3, NHCOCH3, F or Cl; X3 is H, OH, NH2, NHCH3, N(CH3)2, OCH3, F or Cl, provided that when X2 is H, X3 is H, NH2, NHCH3, OCH3, F or Cl; X4 is H, OH, OPO33âˆ’ or OSO32âˆ’ and X5 is H, OH, NH2, NHCH3 or N(CH3)2; each of X6 and X7 is H, OH, â€”OX9, OPO33âˆ’ or OSO32âˆ’; X8 is CH2OH when the sugar is unmodified at the C-6 position, or a group having the formula COOX10, when the sugar is modified at this position; X9 is a tetrose, pentose, hexose or heptose sugar; X10 is H, CH3 or a group having the formula Y1Y2; and wherein no more than two of X2, X3, X4, X5, X6 and X7 are OH and no more than two of X2/X3, X4/X5 and X6/X7 are H/OH or OH/H when X8 is CH2OH.