Patent ID: 6441159
Filing Date: 2002-08-27
Classification: C07B,C07F,C07H,C40B

Abstract:
A phosphoramidite reagent of the formula: whereinR2 is a member selected from the group consisting of C1-C6alkyl and C1-C6acyl, or optionally the two R2 groups are combined to form a ring having from two to four carbon atoms in addition to the oxygen atoms bonded to each of said R2 groups; R3 is a member selected from the group consisting of H, C1-C6alkyl and C3-C6cycloalkyl; Rx is a chain of atoms, optionally including a ring, having an overall length of 2 to 150 atoms, containing carbon to carbon bonds, and optionally carbon to oxygen bonds and optionally including one or more moieties selected from the group consisting of â€”NHâ€”, â€”Oâ€”, â€”NHâ€”C(&boxH;O)â€”, â€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;S)â€”NHâ€”, â€”Sâ€”, â€”OP(O)(Oâˆ’)Oâ€” and â€”Sâ€”Sâ€”; and Q is a member selected from the group consisting of substituted and unsubstituted carbocyclic aromatic rings and heteroaromatic rings.