Patent ID: 6828460
Filing Date: 2004-12-07
Classification: A61K,A61Q,C07C,C07D

Abstract:
A compound of formula l: or a pharmaceutically acceptable salt thereof, wherein:R1 is a (C3-C8)cycloalkyl ring or (C5-C8)cycloalkenyl ring, wherein either the cycloalkyl ring or cycloalkenyl ring is substituted by one to three substituents independently selected from the group consisting of cyano; halo; (C1-C6)alkyl; aryl; (C2-C9)heterocycloalkyl; (C2-C9)heteroaryl; aryl(C1-C6)alkyl-; &boxH;O; &boxH;CHO(C1-C6)alkyl; amino; hydroxy; (C1-C6)alkoxy; aryl(C1-C6)alkoxy-; (C1-C6)acyl; (C1-C6)alkylamino-; aryl(C1-C6)alkylamino-; amino(C1-C6)alkyl-; (C1-C6)alkoxy-COâ€”NHâ€”; (C1-C6)alkylamino-COâ€”; (C2-C6)alkenyl; (C2-C6)alkynyl; hydroxy(C1-C6)alkyl-; (C1-C6)alkoxy(C1-C6)alkyl-; (C1-C6)acyloxy(C1-C6)alkyl-; nitro; cyano(C1-C6)alkyl-; halo(C1-C6)alkyl-; nitro(C1-C6)alkyl-; trifluoromethyl; trifluoromethyl(C1-C6)alkyl; (C1-C6)acylamino-; (C1-C6)acylamino(C1-C6)alkyl-; (C1-C6)alkoxy(C1-C6)acylamino-; amino(C1-C6)acyl-; amino(C1-C6)acyl(C1-C6)alkyl-; (C1-C6)alkylamino(C1-C6)acyl-; ((C1-C6) alkyl)2amino(C1-C6)acyl-; â€”CO2R2; â€”(C1-C6)alkyl-CO2R2; â€”C(O)N(R2)2; â€”(C1-C6)alkyl-C(O)N(R2)2; R2ON&boxH;; R2ON&boxH;(C1-C6)alkyl-; R2ON&boxH;CR2(C1-C6)alkyl-; â€”NR2(OR2); â€”(C1-C6)alkyl-NR2(OR2); â€”C(O)(NR2R2); â€”(C1-C6)alkyl-C(O)(NR2OR2); â€”S(O)mR2; wherein each R2 is independently selected from hydrogen, (C1-C6)alkyl, aryl, or aryl(C1-C6)alkyl-; R3C(O)Oâ€”, wherein R3 is (C1-C6)alkyl, aryl, or aryl(C1-C6)alkyl-; R3C(O)Oâ€”(C1-C6)alkyl-; R4R5Nâ€”C(O)â€”Oâ€”; R4R5NS(O)2â€”; R4R5NS(O)2(C1-C6)alkyl-; R4S(O)2R5Nâ€”; R4S(O)2R5N(C1-C6)alkyl-; wherein m is 0, 1 or 2, and R4 and R5 are each independently selected from hydrogen or (C1-C6)alkyl; â€”C(&boxH;NR6)(N(R4)2); or â€”(C1-C6)alkyl-C(&boxH;NR6)(N(R4)2) wherein R6 represents OR2 or R2 wherein R2 is defined as above; with the proviso that the cycloalkenyl ring is not aromatic; with the proviso that R1 must be substituted by at least one of R3C(O)Oâ€”, R3C(O)Oâ€”(C1-C6)alkyl-, R2ON&boxH;, R2ON&boxH;(C1-C6)alkyl-, R2 ON&boxH;CR2(C1-C6)alkyl-, â€”NR2(OR2), R4R5NS(O)2â€”, R4R5NS(O)2(C1-C6)alkyl-, R4S(O)2R5Nâ€”, or R4S(O)2R5N(C1-C6)alkyl-; with the proviso that when R1 is only substituted by one of R 2ON&boxH;, then R2 cannot be hydrogen.