Patent ID: 6150527
Filing Date: 2000-11-21
Classification: C07D

Abstract:
A compound of a formula selected from the group consisting of ##STR186## wherein G and G' are independently selected from the group comprising of: ##STR187## Q comprises a naturally occuring macrocyclic immunophilin ligand or derivative thereof, or a moiety of the following formula: ##STR188## n and n' are each independently 1 or 2; B.sup.1, B.sup.2, B.sup.1' and B.sup.2' are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, aryl, or heteroaryl moieties;Y and Y' are each independently O, S, NH, --NH(C.dbd.O)--, NH(C.dbd.O)--O--, NH(SO.sub.2)--, NR.sub.3, or a covalent bond;X and X' can be O, NH, or CH.sub.2 ;R.sup.1, R.sup.2, R.sup.1', R.sup.2' and R.sup.3 are the same or different and are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkayl, aryl, or heteroaryl moieties; andL is a covalently linker moeity.