Patent ID: 6353103
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound of the formula: or the pharmaceutically acceptable salts thereof, wherein Ar is phenyl, 1- or 2-naphthyl, 2-, 3-, or 4-pyridinyl, or 4- or 5-pyrimidinyl, each of which is mono-, di-, or trisubstituted with halogen, hydroxy, C1-C6 alkyl, or C1-C6 alkoxy, with the proviso that at least one of the positions on Ar ortho to the point of attachment to the nitrogen-containing aromatic ring is substituted; R1 and R2 are the same of different and represent hydrogen, C1-C6 alkyl, halogen, hydroxy, C1-C6 alkoxy, NH2, NH(C1-C6alkyl), N(C1-C6alkyl)2, NO2, cyano, or trifluoromethyl; R3 and R4 are the same or different and represent hydrogen, C1-C6 alkyl optionally substituted with halogen, hydroxy, or C1-C6 alkoxy; aryl(C1-C6)alkyl, where aryl is phenyl, 1- or 2-naphthyl, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl or 2-, 4-, or 5-pyrimidinyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy; or c1-C6 alkyl-Yâ€”R5, wherein Y is O, S, NH, or N(C1-C6 alkyl), and R5 is hydrogen or C1-C6 alkyl; and W is N or Câ€”R6, wherein R6 is hydrogen or C1-C6 alkyl.