Patent ID: 6031105
Filing Date: 2000-02-29
Classification: C07D

Abstract:
A process for the preparation of a compound of formula (II), ##STR28## comprising, reacting a compound of formula (III), ##STR29## with a vinyl ether of formula (IV), CH.sub.2 .dbd.CHOR.sup.4, in the presence of a palladium compound or a palladium metal catalyst, a phosphine and a base;whereinX.sup.1 is bromo,R.sup.1 is selected from the group consisting of --NR.sup.3 --CO--(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --CO--(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --SO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --SO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl) and --NR.sup.3 --CO--(C.sub.1 -C.sub.4)perfluoroalkyl;R.sup.2 is selected from the group consisting of hydrogen, amino, nitro, (C.sub.1 -C.sub.8)alkyl-amino, fluoro, CF.sub.3, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, --NR.sup.3 --CO--(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --CO--(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --SO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --SO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl) and --NR.sup.3 --CO--(C.sub.1 -C.sub.4)perfluoroalkyl;where a for each occurrence is independently 0, 1, 2, 3 or 4;R.sup.3 for each occurrence is independently selected from the group consisting of hydrogen and (C.sub.1 -C.sub.6) alkyl;the optionally substituted phenyl group is optionally substituted with one, two or three substituents, each substituent is independently selected from the group consisting of hydroxy, fluoro, chloro, iodo, bromo, CF.sub.3, sulfonamide, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, carboxy, hydroxyalkyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, (C.sub.1 -C.sub.4)thioalkyl, sulfonyl, sulfinyl and amino; andR.sup.4 is (C.sub.1 -C.sub.6)alkyl.