Patent ID: 9168291
Filing Date: 2015-10-27
Classification: A61K,A61P,C07H

Abstract:
1. A method for activating a mammalian NKT cell in vitro comprising: culturing in vitro a mononuclear cell fraction comprising one or more mammalian NKT cells in the presence of a composition in an amount sufficient to activate a mammalian NKT cell in vitro, wherein the composition comprises a β-mannosylceramide (β-ManCer) or salt or solvate thereof in a pharmaceutically acceptable carrier, wherein the β-ManCer consists of a β-mannosyl moiety linked to a ceramide moiety, the ceramide moiety consisting of: a) a sphingosine moiety linked to b) a fatty acid moiety comprising a linear or branched, saturated or unsaturated, aliphatic hydrocarbon group having from about 8 to about 49 carbon atoms.