Patent ID: 6114357
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
The compounds of the invention are represented by structural Formula (I) ##STR6## wherein: A.sub.1 and A.sub.2 independently from each other denote a group Z(CH.sub.2)k--(NR'"")q wherein: Z is a 4-10 membered mono- or bicyclic heterocyclic ring system containing up to four heteroatoms N, O, S in the ring in which at least one heteroatom is N, and wherein the ring is substituted or unsubstituted by one or two C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.4, oxo, oxime, O--C.sub.1-4 alkyloxime, hydroxy, N(R.sub.3).sub.2, acylamino or aminoacyl groups, 8, 9, 10 membered monocyclic ring systems being excluded;k is independently an integer from 0 to 4;R'"" denotes hydrogen, C.sub.1-4 -alkyl or C.sub.1-4 -alkylcarboxylic acid;q is independently an integer from 0 to 1;R' and R"" are independently hydrogen, C.sub.1-4 alkylC(O)R.sub.4, C.sub.1-4 alkyl or R' and R"" are benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sub.3).sub.2 ;Q denotes a group ##STR7## wherein: B.sub.1 denotes halogen, --(CH.sub.2).sub.m --CN, --(CH.sub.2).sub.m+1 --R.sup.2, --(CH.sub.2).sub.m --R.sup.3, --(CH.sub.2).sub.m --COR.sup.2 or --(CH.sub.2).sub.m --COR.sup.3 ;R.sup.2 independently denotes --OR.sup.3, --N(R.sup.3).sub.2, --SR.sup.3 ;R.sup.3 is independently hydrogen, C.sub.1 --C.sub.4 -alkyl or benzyl;m is independently an integer from 0 to 4;C.sub.1 denotes halogen, --(CH.sub.2).sub.n --CN, --(CH.sub.2).sub.n+1 --R.sup.4, --(CH.sub.2).sub.n --R.sup.5, --(CH.sub.2).sub.n --COR.sup.4 or --(CH.sub.2).sub.n --COR.sup.5 ;R.sup.4 independently denotes --OR.sup.5, --N(R.sup.5).sub.2, --SR.sup.5 ;R.sup.5 is independently hydrogen, C.sub.1 --C.sub.4 -alkyl or benzyl;n is independently an integer from 0 to 4;B.sub.2 denotes halogen, --(CH.sub.2).sub.p --CN, --(CH.sub.2).sub.k+1 --R.sup.6, --(CH.sub.2).sub.k --R.sup.7, --(CH.sub.2).sub.k --COR.sup.6 or --(CH.sub.2).sub.k --COR.sup.7 ;R.sup.6 independently denotes --OR.sup.7, --N(R.sup.7).sub.2, --SR.sup.7 ;R.sup.7 is independently hydrogen, C.sub.1 --C.sub.4 -alkyl or benzyl;k is an integer from 0 to 4;C.sub.2 denotes halogen, --(CH.sub.2).sub.S --CN, --(CH.sub.2).sub.S+S --R.sup.8, --(CH.sub.2).sub.S --R.sup.9, --(CH.sub.2).sub.S --COR.sup.8 or --(CH.sub.2).sub.S --COR.sup.9 ; whereR.sup.8 independently denotes --OR.sup.9, --N(R.sup.9).sub.2, --SR.sup.9 ;R.sup.9 is independently hydrogen, C.sub.1 --C.sub.4 -alkyl or benzyl;s is an integer from 0 to 4;D is (CH.sub.2).sub.i ; in which up to two carbons are optionally gem-substituted by R.sup.10 and R.sup.11 ; whereR.sup.10 and R.sup.11 are independently C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl; all of which may be substituted by one or two C.sub.1-4 alkyl, OH, F, Cl, Br, I, N(R.sup.12).sub.2, (R.sup.12).sub.2 NC(O)--, --(CH.sub.2).sub.S R.sup.13, --(CH.sub.2).sub.S R.sup.12, --(CH).sub.2).sub.S COR.sup.13, or --(CH.sub.2).sub.S C(O)R.sup.12 ;or R.sub.10 and R.sub.11 are F, Cl, or Br;or R.sub.10 and R.sub.11 may together form a cyclic or heterocyclic ring of Formula (Ia): ##STR8## in which p and q are independently an integer from 0 to 3; provided p and q are not both 0;X is O, S, CH.sub.2 or N(R.sup.12);R.sup.12 is independently hydrogen, C.sub.1-4 -alkyl or benzyl;R.sup.11 is independently OR.sup.12, N(R.sup.12).sub.2 or SR.sup.12 ;i is an integer from 3 to 8;with the proviso that B.sub.1 is not identical to C.sub.1 and B.sub.2 is not identical to C.sub.2 ;A.sub.1 .noteq.A.sub.2 ;B.sub.1 .noteq.B.sub.2 ;C.sub.1 .noteq.C.sub.2 ;B.sub.1 .noteq.C.sub.1 ; andB.sub.2 .noteq.C.sub.2 ;and pharmaceutically acceptable salts thereof.