Patent ID: 6440937
Filing Date: 2002-08-27
Classification: A61K,A61P,C07D,C07K,Y02P

Abstract:
A compound of the formula I whereinl is 0 or 1, m is 0, 1 or 2, n is 0, 1 or 2, R is hydrogen or C1-4-alkyl, R1 is HOOCâ€”, C1-6-alkyl-OOC, benzyl-OOC or hydroxyl, R2 is hydrogen, C1-4-alkyl or R1â€”(CH2)m, R3 is hydrogen or C1-4-alkyl which is unsubstituted or substituted by hydroxyl or COOH, R4 is hydrogen, C1-4-alkyl, HOOCâ€”C1-4-alkylene, R5 is C1-8-alkyl, cycloalkyl-(CR8R9)r (r=0 or 1, R8, R9=hydrogen, cycloalkyl or C1-4-alkyl), wherein up to four CH2 groups of the cycloalkyl radical may be replaced, independently from one another, by CR10R11 (R10=hydrogen or C1-4-alkyl, R11=C1-4-alkyl) and/or the CH group in the cycloalkyl radical which is bonded to CR8R9 may be replaced by CR12 (R12=C1-4-alkyl), and/or one or two Câ€”C single bond(s) of the cycloalkyl ring may be replaced by a C&boxH;C double bond, R6 is hydrogen, C1-4-alkyl, or R4 and R5 are together CH2â€”CH2â€”CH(R7), (R7=hydrogen, phenyl or cyclohexyl), or R2 and R5 are together CH2â€”CH2 or CH2â€”CH2â€”CH2, in which one hydrogen atom may be replaced by C1-4-alkyl, phenyl or cycloalkyl, or a salt thereof.