Patent ID: 6656497
Filing Date: 2003-12-02
Classification: A61K,Y10S,Y10T

Abstract:
A liposomal vector for an active-principle, comprising:(a) a pulverulent composition, which comprises unilamellar liposomes, said liposomes, comprising: (1) an external lipid phase which consists essentially of phospholipids; and (2) an internal aqueous nucleus forming a temperature-reversible aqueous gel which radiates out up to the external lipid phase, which internal aqueous nucleus consists essentially of a mixture M of at least two different non-polymerizable gelatinizing agents G1 and G2, whose gel-sol phase transition point is higher than or equal to 37Â° C., with G1 being a gelatinizing agent which is selected from the group consisting of gelatin and carrageenans, and G2 being selected from the group consisting of carrageenans whose properties are different from the carrageenans selected for G1, and celluloses; which liposomes have a diameter of between 20 nm and 200 nm; and wherein the pulverulent composition is present in the form of particulate units which have a mean diameter of between 10 &mgr;m and 1000 &mgr;m and which are formed from one or more of the liposomes which is/are surrounded by a matrix which is selected from the group consisting of a dehydrated temperature-reversible aqueous gel which is selected from the group consisting of gelatin, carrageenans, dextrins and mixtures thereof, such that it contains, on average, from 1016 to 1018 liposomes/g of powder; and (b) at least one active principle, wherein the active principle is in the gelatinized internal core or in the external lipid phase.