Patent ID: 8987480
Filing Date: 2015-03-24
Classification: C07B,C07D

Abstract:
1. A process of separating chiral isomers of formula (I-A) or (I-B) or (I-C): wherein R R R and wherein * represents the chiral centre of the chiral isomer of formula (I-A) or (I-B) or (I-C); the process comprising the steps of: a) providing a mixture of at least two isomers of formula (I-A) or (I-B) or (I-C); b) performing chromatographic separation of the mixture of isomers of formula (I-A) or (I-B) or (I-C) by means of a chiral phase into desired isomer (I) and residual (I′); c) isomerizing the chirality at the centre indicated by * in formula (I-A) or (I-B) or (I-C) of the isomers of the residual (I′) being separated in step b); d) adding the isomerized isomers obtained in step c) to a mixture of at least two isomers of formula (I-A) or (I-B) or (I-C) being object of further separation; and e) collecting the desired isomer (I).