Patent ID: 6215040
Filing Date: 2001-04-10
Classification: A01K,C07K,C12N

Abstract:
A transgenic mouse whose genome contains a chimeric DNA sequence, said chimeric DNA sequence comprising:a basal keratinocyte specific transcription control sequence and a DNA segment which encodes interleukin-5, wherein the basal keratinocyte specific transcription control sequence and the DNA segment which encodes interleukin-5 are operatively linked to each other and are integrated into the genome of the mouse, wherein the DNA segment that encodes interleukin-5 lacks endogenous interleukin-5 control sequences which are 5' to the interleukin-5 coding sequence, and wherein the DNA segment is expressed so as to result in elevated levels of eosinophils in the blood and skin, increased thickening of the skin or an increased inflammatory response to oxazolone in the transgenic mouse relative to a corresponding nontransgenic mouse.