Patent ID: 7820640
Filing Date: 2010-10-26
Classification: A61K,A61P

Abstract:
1. A method for ameliorating hearing loss in a mammalian subject, comprising the step of administering to a mammalian subject an amount of an otoprotective composition effective to ameliorate hearing loss, wherein the otoprotective composition comprises: (a) a pharmaceutically effective amount of at least one otoprotectant selected from the group consisting of allopurinol, 1-methylallopurinol, 2-methylallopurinol, 5-methylallopurinol, 7-methylallopurinol, 1,5-dimethylallopurinol, 2,5-dimethylallopurinol, 1,7-dimethylallopurinol, 2,7-dimethylallopurinol, 5,7-dimethylallopurinol, 2,5,7-trimethylallopurinol, 1-ethoxycarbonylallopurinol, 1-ethoxycarbonyl-5-methylallopurinol, and pharmaceutically effective salts thereof; and (b) a pharmaceutically effective amount of at least one otoprotectant selected from the group consisting of methionine, N-acetyl-DL-methionine, S-adenosylmethionine, cysteine, homocysteine, cysteamine, N-acetylcysteine, glutathione, glutathione ethylester, glutathione diethylester, glutathione triethylester, cysteamine, cystathione, N,N′-diacetyl-L-cysteine (DiNAC), 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)-thiazolidine-4(R)-carboxylic acid (RibCys), 2-alkylthiazolidine 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidine (RibCyst), 2-oxo-L-thiazolidine-4-carboxylic acid (OTCA), and pharmaceutically effective salts thereof.