Patent ID: 6130234
Filing Date: 2000-10-10
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I) ##STR141## or a pharmaceutically acceptable salt thereof wherein Ar.sup.1 is aryl and Ar.sup.2 is a bicyclic heteroaryl group, either of which may be independently substituted by hydrogen, hydroxy, alkyl, halogen, nitro, aryl, aralkyl, amino, a halogenated alkyl group, --NHAc, --NHSO.sub.2 Me, --N(SO.sub.2 Me).sub.2, --CONHalkyl, --SO.sub.2 NH.sub.2, an alkylguanidine group, a lower alkyl amino group or a lower alkoxy group;z is a single bond;X is --(CHR2)m--, wherein each R2 is hydrogen and m is 1;R1 is hydrogen or hydroxy;n is 1 or 2;Q is --C.tbd.C--; andR4 is hydrogen or hydroxy.