Patent ID: 6495700
Filing Date: 2002-12-17
Classification: C07D

Abstract:
A process of producing a phenserine compound of the Formula wherein R is a lower alkyl; and R1 is a cycloalkyl, phenyl, phenyl lower alkyl or cycloalkyl lower alkyl, or a salt thereof comprisinga) treating a purified eseroline compound of the formula wherein R is as above with a strong organic base in an anhydrous reaction medium containing an inert aprotic water miscible organic solvent; andb) reacting treated in said reaction medium, said treated eseroline compound with an isocyanate of the formula R1â€”N&boxH;C&boxH;Oâ€ƒâ€ƒV wherein R1 is as above, by mixing said isocyanate with said reaction medium so as to form said phenserine compound.