Patent ID: 7223440
Filing Date: 2007-05-29
Classification: A61K,A61P,B01J

Abstract:
1. A method for preparing microparticles, comprising: preparing an emulsion comprising an aqueous peptide solution and a biodegradable, biocompatible polymer dissolved in a halogenated solvent; combining the emulsion with a coacervating agent that is free from solvents for the polymer to form a combined phase; extracting the halogenated solvent from the combined phase with an extraction medium, that is a non-solvent for the polymer and a solvent for the halogentated solvent and the coacervating agent, whereby microparticles precipitate out of the extraction medium; rinsing the precipitated microparticles to form finished microparticles; and after said rinsing step, washing the finished microparticles in a non-aquesous washing system comprising 100% heptane to thereby reduce the level of residual halogenated solvent.