Patent ID: 8785409
Filing Date: 2014-07-22
Classification: A61K,C07H

Abstract:
1. A compound having a structure represented by o-(x-L) n , where (a) o is a polynucleoside moiety comprising a sequence of nucleosides and linkage moieties, wherein (i) at least 50% of said linkage moieties are selected from: 3′-NH—P(O)(S and at least 75% of internucleoside linkage moieties are selected from 3′-NH—P(O)(S where Y is NH or O; R is a stable linear chain two to six atoms in length having bonds selected from alkyl, alkenyl, ether, thioether, and amino; and m is 1 to 3; and (ii) said polynucleoside moiety includes at least one motif selected from GGG, GGWGG, and GGWWGG, containing residues selected from G and W, where G is guanosine and W is a nucleoside or the moiety —OR—, where R is as defined above, and the inter-residue linkages within said motif are N3′→P5′ thiophosphoramidate (3′-NH—P(O)(S (b) x is an optional linker group, (c) L is a lipid moiety comprising a linear hydrocarbon moiety at least 12 carbon atoms in length, and (d) n is 1 or 2; wherein the compound o-(x-L)