Patent ID: 6812244
Filing Date: 2004-11-02
Classification: A61P,C07C,C07D,Y02P

Abstract:
A compound of formula I whereinR1 is â€”H, â€”OH, â€”O(C1-C4 alkyl), â€”OCOAr where Ar is phenyl or substituted phenyl, â€”O(CO)OAr where Ar is phenyl or substituted phenyl, â€”OCO(C1-C6 alkyl), â€”O(CO)O(C1-C6 alkyl), or â€”OSO2(C4-C6 alkyl); R2 is â€”H, â€”F, â€”Cl, â€”OH, â€”O(C1-C4 alkyl), â€”OCOAr where Ar is phenyl or substituted phenyl, â€”O(CO)OAr where Ar is phenyl or substituted phenyl, â€”OCO(C1-C6 alkyl), â€”O(CO)O(C1-C6 alkyl), or â€”OSO2(C4-C6 alkyl); R3 and R4 are, independently, â€”H, â€”F, â€”Cl, â€”CH3, â€”OH, â€”O(C1-C4 alkyl), â€”OCOAr where Ar is phenyl or substituted phenyl, â€”OCO(C1-C6 alkyl), â€”O(CO)O(C1-C6 alkyl), or â€”OSO2(C4-C6 alkyl), with the proviso that both R3 and R4 cannot be hydrogen; n is 2 or 3; and R5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof.