Patent ID: 8417498
Filing Date: 2013-04-09
Classification: G01N

Abstract:
1. A method of identifying a candidate compound that binds to the active site of Arabidopsis thaliana peptide deformylase polypeptide, the method comprising: a) comparing, by a processor of a computer, the atomic structure of the compound with a three-dimensional structure of a crystalline form of an b) computationally identifying by the processor a candidate compound for an ability to bind to the wherein said computer has the atomic coordinates of said polypeptide stored therein, and wherein said three-dimensional structure is generated from the structure coordinates of Table 1 or homologous structures coordinates for the amino acid residues of SEQ ID NO: 1 comprising a root mean square deviation of non-hydrogen atoms of less than about 0.35 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 1.