Patent ID: 6617346
Filing Date: 2003-09-09
Classification: A61P,C07D

Abstract:
A compound of formula I and the pharmaceutically acceptable salts and esters thereof, whereinZ1, Z2 and Z3 are each independently selected from lower alkoxy, â€”CH2OCH3, and â€”CH2OCH2CH3, or one of Z1, Z2 or Z3 is â€”H and the other two are each independently selected from lower alkyl, lower alkoxy, â€”Cl, â€”Br, â€”F, â€”CF3, â€”CH2OCH3, â€”CH2OCH2CH3, â€”OCH2CH2R1, â€”CH2-morpholino, â€”OR2, â€”CH2R2, â€”OCH2CF3, â€”OCH(CH3)CH2OH and â€”COOQ, wherein Q is selected from â€”H and lower alkyl, or one of Z1, Z2 or Z3 is â€”H and the other two taken together with the two carbon atoms and the bonds between them from the benzene ring to which they are substituted form a ring selected from 5- and 6-membered unsaturated rings, and 5- and 6-membered saturated rings that contain at least one hetero atom selected from S, N, and O, wherein R1 is selected from â€”F, â€”OCH3, â€”N(CH3)2, and unsaturated 5-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O, wherein R2 is a 3- to 6-membered saturated ring, and Y1 and Y2 are each independently selected from â€”Cl, â€”Br, â€”NO2, â€”Câ‰¡N and â€”Câ‰¡CH.