Patent ID: 8470776
Filing Date: 2013-06-25
Classification: A61P,C07D,C07K,C12P

Abstract:
1. A method for the treatment of ovarian, endometrial, cervical, uterine, prostate, bladder, liver, stomach, pancreatic, breast, colon, brain, lung or skin cancer, multiple myeloma, lymphoma or leukemia, comprising administering to a patient in need thereof a compound of the formula (I) or (IV): wherein A is a disorazole moiety according to formula (III) wherein Ri R R27 and R29 together form a double bond or an epoxide; R37 and R39 together form a double bond or an epoxide; R25 and R26 are independently from each other selected from the group consisting of: alkyl which is optionally substituted in the alkyl group by 1, 2 or 3 substituents independently from each other selected from the group consisting of alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, heteroaryl, aryl-alkyl, heteroaryl-alkyl, heterocyclyl, heterocyclyl-alkyl, alkylsulfonyl, arylsulfonyl, aryl-alkylsulfonyl, halogen, —F, —Cl, —Br, —I, —N B1 and B2 are independently from each other selected from the group consisting of dicarbonic acid residue linker, succinyl and glutaryl; C1 and C2 are independently from each other selected from the group consisting of LHRH, [D-Lys o is 1 or 2; and p is 1 or 2.