Patent ID: 7585882
Filing Date: 2009-09-08
Classification: A61P,C07D

Abstract:
1. A compound selected from: 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-methylisoxazol-3-yl)acetamide, 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide, 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide, 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(6-methylpyridin-2-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)acetamide, 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide, N-(cyclopropylmethyl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide, N-(cyclopropylmethyl)-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide, N-(cyclopropylmethyl)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide, 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide, 2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide, N-(3-fluorophenyl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methyl-1H-pyrazol-5-yl)acetamide, 2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)-N-methylacetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methoxy-1,3-benzothiazol-2-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methyl-N-(3-methylisothiazol-5-yl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-methylisoxazol-3-yl)acetamide, (2S)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, (2R)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, (2S)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, (2R)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, (2R)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide, (2S)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide, N-(3-fluorophenyl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide, N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide, N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide, (2S)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)propanamide, (2R)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)propanamide, (2R)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, (2S)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)acetamide, (2S)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)propanamide, (2R)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)propanamide, 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide, 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, 2-{(4S)-4-[4-difluoromethoxy-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide, and N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-difluoromethoxy-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide, and pharmaceutically acceptable salts thereof, solvates thereof, and wherein if the compound exhibits chirality it can be in the form of a mixture of enantiomers such as a racemate or a mixture of diastereomers, or can be in the form of a single enantiomer or a single diastereomer.