Patent ID: 8211405
Filing Date: 2012-07-03
Classification: A61K,A61P

Abstract:
1. A method of making a dry powder formulation for inhalation, the dry powder formulation comprising active particles and carrier particles for supporting the active particles, and magnesium stearate in an amount of at least 0.5% by weight of the formulation, the method comprising the step of blending the magnesium stearate with a carrier material in a low energy blender, wherein the energy consumption of said blender is from 0.10 to 1 kilowatt per 100 liters, for a period of less than 30 minutes to form a mixture in which particles of magnesium stearate are disposed on the surface of the carrier particles, wherein the coverage of the magnesium stearate on the surface of the carrier particles is less than 5%, and wherein said dry powder formulation is prepared without high shear mixing or milling steps.