Patent ID: 7220569
Filing Date: 2007-05-22
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A recombinant nucleic acid comprising a nucleic acid segment that encodes a Factor X analogue, wherein said analogue is a Factor X that has one or more amino acid modifications in a region between Gly228 and Arg234 of SEQ ID NO:27 that results in a sequence Gly228-R6-R5-R4-R3-R2-Arg234-R1 and wherein a) R1 is an amino acid selected from the group consisting of Ile, Val, Ser, Thr and Ala; b) R2 is an amino acid selected from the group consisting of Pro, Gly, Lys and Arg; c) R3 is an amino acid selected from the group consisting of Phe, Lys, Met, Gln, Glu, Ser, Val, Arg and Pro; d) R4 is an amino acid selected from the group consisting of Asp, Ile, Ser, Met, Pro, Thr, Arg and Lys; e) R5 is an amino acid selected from the group consisting of Asn, Lys, Ser, Glu, Ala, Gln, His and Arg; and f) R6 is an amino acid selected from the group consisting of Asp, Phe, Thr, Arg, Leu and Ser.