Patent ID: 6229019
Filing Date: 2001-05-08
Classification: C07F

Abstract:
A process for producing a compound having formula (IV): ##STR14##wherein Cy is cyclohexyl, R.sup.4 and R.sup.5 are identical or different and are independently a substituted or unsubstituted aromatic hydrocarbon, and R.sup.6 is hydrogen or a protecting group for an imino group,which comprises(i) reacting a compound having formula (I): ##STR15##wherein R.sup.1 is a protecting group for an imino group, R.sup.2 and R.sup.3 are identical or different and are independently a protecting group for a hydroxy group,with a metal phosphine compound and a boron compound to form a compound having formula (II): ##STR16##wherein R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are defined above and B.sup.1 is a first boron compound,(ii) reacting compound (II) with a metal dicyclohexylphosphine compound and a boron compound to form a compound having formula (III): ##STR17##wherein Cy, R.sup.1, R.sup.4, R.sup.5 and B.sup.1 are defined above and B.sup.2 is a second boron compound which is identical or different to B.sup.1,(iii) removing the boron compounds B.sup.1 and B.sup.2 from compound (III) using a reagent capable of cleaving phosphorous-boron bonds, and(iv) retaining R.sup.1, or replacing R.sup.1 with hydrogen, to obtain compound (IV).