Patent ID: 6124495
Filing Date: 2000-09-26
Classification: C07C

Abstract:
A method of treating, preventing or ameliorating cancer or other proliferative disorder in a subject which comprises administering an amount of a compound effective to treat, prevent or ameliorate said cancer or said disorder, wherein said compound is represented by the formula: ##STR32## wherein R is C.sub.2 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.2 to C.sub.10 alkynyl, aryl or heteroaryl, any of which can be optionally substituted with halo, trifluoromethyl, hydroxy, alkoxy, cyano, nitro or carbonyl, wherein the heteroatom of said heteroaryl is oxygen or sulfur;R.sup.1 and R.sup.2 are independently H, C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, or C.sub.2 to C.sub.10 alkynyl, any of which can be optionally substituted with halo, alkoxy, amino, trifluoromethyl, aryl or heteroaryl;A is ##STR33## R.sup.3 is independently ##STR34## R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are independently H, alkyl or alkenyl;B is aryl or heteroaryl, wherein the heteroatom of said heteroaryl is oxygen or sulfur;m and n are independently 0 to 5;the sum of m and n is 1 to 5;p, q and r are independently 0 to 2; ora pharmaceutically-acceptable salt thereof;with the proviso that when p, q and r are 0, each R.sup.3 is --CR.sup.6 .dbd.CR.sup.7 --, R.sup.6 is H or methyl and R.sup.7 is H or methyl, then the sum of m and n can not be 4 or 5.