Patent ID: 6903217
Filing Date: 2005-06-07
Classification: C07D

Abstract:
1. A compound of formula (III) wherein: X X X X X  and, optionally, one of X R  for which Ra and Rb are independently hydrogen, alkyl, cycloalkyl, phenyl, mono- or bicyclic aromatic heterocyclyl, or Ra and Rb form, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain an additional heteroatom chosen from O, S and N and, when the additional heteroatom is N, the additional heteroatom optionally is substituted with an alkyl, phenyl or mono- or bicyclic aromatic heterocyclyl substituent and, when the additional heteroatom is S, the additional heteroatom optionally is sulfinyl or sulfonyl, or R  for which Ra and Rb are defined as above, and are additionally chosen from phenoxy, heterocyclyloxy, benzyloxy, and heterocyclylmethyloxy, or R R′ or a methylene radical substituted with fluoro, hydroxyl, alkyloxy, alkylthio, cycloalkyloxy, cycloalkylthio, phenyl, mono- or bicyclic aromatic heterocyclyl, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, —NRaRb or —CONRaRb  for which Ra and Rb are defined as above, and are additionally chosen from phenoxy, heterocyclyloxy, benzyloxy, and heterocyclylmethyloxy; Hal is chlorine, bromine or iodine; wherein any alkyl or acyl radical or portion, unless otherwise indicated, comprises from 1 to 10 carbon atoms in a straight or branched chain, and any cycloalkyl radical comprises from 3 to 6 carbon atoms; with the proviso that the compound of formula (III) is not 3-fluoro4-chloro-6,7-dimethoxy-quinoline.