Patent ID: 6630138
Filing Date: 2003-10-07
Classification: A61K,A61P,C12N,C12Y

Abstract:
A human protein C derivative comprising SEQ ID NO: 1 wherein,Asp at position 167 is substituted with Phe, Asp at position 172 is substituted with Lys, and further comprising at least one amino acid substitution selected from the group consisting of:(a) His at position 10, Ser at position 11, or Ser at position 12 are independently substituted with any amino acid, (b) Gin at position 32 is substituted with Glu, (c) Asn at position 33 is substituted with Asp or Phe, and (d) amino acids at positions 194, 195, 228, 249, 254, 302, or 316 are substituted with an amino acid selected from Ser, Ala, Thr, His, Leu, Lys, Arg, Asn, Asp, Glu, Gly, and Gln.