Patent ID: 6692956
Filing Date: 2004-02-17
Classification: A61K,A61P,C07K,C12N

Abstract:
A recombinant adenoviral vector in which at least a part of the E3 region is deleted or is rendered non-functional, wherein said adenoviral vector retains E3 sequences encoding:(i) a functional 14.7K protein, and optionally (ii) a functional 14.5K protein and a functional 10.4K protein, wherein said recombinant adenoviral vector comprises a gene of interest; wherein said retained E3 sequences and said gene of interest are operably linked to regulatory elements allowing their expression in a host cell; wherein said retained E3 sequences encoding a functional 14.7K protein are located in said adenoviral vector either (i) at a location where the E3 region normally resides and in antisense orientation relative to the direction of transcription of the native E3 region or (ii) wherein the E1 region normally resides and in sense orientation relative to the direction of transcription of the native E1 region; and wherein said retained E3 sequences encoding a functional 14.5K protein and a functional 10.4K protein are located in said adenoviral vector at a location where the E3 region normally resides and in sense orientation relative to the direction of transcription of the native E3 region.