Patent ID: 6630470
Filing Date: 2003-10-07
Classification: A61P,C07D

Abstract:
A compound of the Formula (1): wherein R1 and R2 are independently aryl, where aryl is cyclic or polycyclic aromatic C3-C12, optionally containing one or more heteroatoms, provided that when C is 3 the aromatic ring contains at least two heteroatoms, and when C is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of: C(O)NR11R12, NR11R12, aryloxy, cycloalkyl, substituted cycloalkyl, alkyl, C6-C12aryl, alkoxy, acyloxy, substituted C6-C12aryl, trifluoromethyl, methoxycarbonyl, amino, N-acylamino, nitro, cyano, halogen, hydroxy, â€”C(O)OR11, â€”S(O)2NR11R12, â€”S(O)nR13, protected â€”OH and alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, C6-C12aryl, substituted C6-C12aryl, amino, N-acylamino, oxo, hydroxy, cycloalkyl, substituted cycloalkyl, â€”C(O)OR11, â€”S(O)2NR11R12, â€”S(O)nR13, aryloxy, nitro, cyano, halogen and protected â€”OH, where R11 and R12 are independently hydrogen, cycloalkyl, C6-C12aryl, substituted cycloalkyl, substituted C6-C12aryl, alkyl or alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, aryloxy, amino, N-acylamino, oxo, hydroxy, â€”C(O)OR13, â€”S(O)nR13, C(O)N(R13)2, S(O)2N(R13)2, nitro, cyano, cycloalkyl, substituted cycloalkyl, halogen, C6-C12aryl, substituted C6-C12aryl and protected â€”OH, n is 0-2, R13 is hydrogen, alkyl, cycloalkyl, C6-C12aryl, substituted alkyl, substituted cycloalkyl and substituted C6-C12aryl; R3, R4, R5, R6, R7, R8, R9 and R10 are independently hydrogen, C(O)NR11R12, NR11R12, aryloxy, cycloalkyl, substituted cycloalkyl, alkyl, C6-C12aryl, alkoxy, acyloxy, substituted C6-C12aryl, amino, N-acylamino, nitro, cyano, halogen, hydroxy, â€”C(O)OR11, â€”S(O)2NR11R12, â€”S(O)nR13, protected â€”OH and alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, C6-C12aryl, substituted C6-C12aryl, amino, N-acylamino, oxo, hydroxy, cycloalkyl, substituted cycloalkyl, â€”C(O)OR11, â€”S(O)2NR11R12, â€”S(O)nR13, aryloxy, nitro, cyano, halogen and protected â€”OH, where R11, n, R12 and R13 are as described above; X is O, S or NR11, where R11 is as described above; and Y is O or S; or pharmaceutically acceptable salt, hydrate, or solvate thereof.