Patent ID: 6634576
Filing Date: 2003-10-21
Classification: A61K

Abstract:
A process for preparing a synergetic commixture comprising small particles of a solid substrate and small particulates of a first material of a desired size, said process comprising:a) providing to a milling chamber of a media mill a contents comprising a pre-mix of a solid substrate, a fluid carrier, a plurality of milling bodies of a first material, and a plurality of milling bodies of a second material; b) operating said media mill to grind said solid substrate and degrade at least a portion of said milling bodies of the first material to produce a dispersion in said fluid carrier comprising a synergetic commixture of small particulates of said first material and small particles of said solid substrate having a desired size equal to or less than a size Sp; c) separating said dispersion from any residual milling body, piece of milling body, and solid substrate having a size larger than Sp; and d) optionally removing said fluid carrier from said dispersion to form a dry synergetic commixture comprising said particles and said small particulates; wherein the milling bodies of said first material are fractured and eroded by the milling bodies of said second material, the milling bodies of said second material are essentially resistant to fracture and erosion in the milling process, and Sp is smaller than the size of the milling bodies of the second material.