Patent ID: 6225335
Filing Date: 2001-05-01
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR11##or a pharmaceutically acceptable salt thereof, wherein:R.sub.1 is H or alkyl;R.sub.2 is O or S;R.sub.3 is hydrogen;R.sub.4 is selected from the group consisting of an alkyl with at least two carbons, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, a halogen selected from the group consisting of Br, I and F, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.2 CO.sub.2 R, and CONRR';R.sub.5 is selected from the group consisting of hydrogen, an alkyl with at least two carbons, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, a halogen selected from the group consisting of Br, I and F, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.2 CO.sub.2 R, and CONRR';R.sub.6 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.2 CO.sub.2 R, and CONRR';R.sub.7 is selected from the group consisting of hydrogen, an alkyl of at least two carbons, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.2 CO.sub.2 R, and CONRR';R.sub.2' is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, a halogen selected from the group consisting of Br, F and I, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, and CONRR';R.sub.3' is selected from the group consisting of alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, a halogen selected from the group consisting of Br, F and I, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, and CONRR';R.sub.5' is selected from the group consisting of alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, and CONRR';R.sub.6' is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO.sub.2 NRR', SO.sub.3 R, SR, NO.sub.2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH.sub.2).sub.n CO.sub.2 R, and CONRR';n is 0-3;Z is Br, Cl, F, I, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl;R is H, alkyl, or aryl;and R' is H, alkyl or aryl.