Patent ID: 9138427
Filing Date: 2015-09-22
Classification: A61K,A61P,C07D

Abstract:
1. A method of treatment of pulmonary hypertension, ARDS, asthma, pneumonia, pulmonary fibrosis/interstitial lung diseases, cystic fibrosis, and chronic obstructive pulmonary disease (COPD) comprising administering a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof: wherein Ar is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R R R R n is 0-3; wherein Ar excludes substituted or unsubstituted indazol-3-yl and substituted or unsubstituted 1H-pyrazolo[3,4-b]pyridyl; with the following provisos: proviso Ia: when R proviso Ib: when R