Patent ID: 6124352
Filing Date: 2000-09-26
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition usefull for treating fungal infections, comprising an effective antifungal amount of a compound of the formula (I): ##STR15## wherein S is a spacer selected from a nitrogen, an oxygen, an alkyl, an alkenyl, an alcohol, an ester, a polyester, an amino acid, a carbohydrate, or a nitrogen-containing positively charged group;L is a ligand selected from a hydrogen, a hydroxyl residue, an alkyl residue, an alkenyl residue, a benzyl residue, an alcohol residue, an ester residue, a polyester residue, an alkyl acid residue, a carbohydrate, a steroid, a lipid, an organic polymer, a nitrogen-containing positively charged group, or a vitamin;R.sub.1 and R.sub.3 are halogen; andR.sub.2 is hydrogen or alkyl,provided that L is not hydrogen when S is oxygen and R.sub.2 is hydrogen or methyl, andprovided that L is not a methyl, ethyl, or benzyl residue when S is oxygen,and addition salts, hydrates, and solvates thereof in combination with a pharmaceutically accepted vehicle.