Patent ID: 8101604
Filing Date: 2012-01-24
Classification: A61P,C07D

Abstract:
1. A method of treating cancer in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof wherein, R 1 is hydrogen, C 1 -C 4 aliphatic, —C(O)N(R 1a ) 2 , —C(O)R 1b , or —(CH 2 ) n R 1c , wherein each occurrence of R R R R n is 1, 2 or 3; R 2 is hydrogen or C 1 -C 4 aliphatic; R 3 is —H, -T 1 -R 3d , —V 1 -T 1 -R 3d , or —R 3e , wherein V T each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of R each R′ is independently hydrogen or optionally substituted C x is 0-4; each occurrence of R 4 is independently —R 4a , -T 2 -R 4d , or —V 2 -T 2 -R 4d , wherein: each occurrence of R each occurrence of R each occurrence of R each occurrence of R each occurrence of V each occurrence of T R 5 is —NR 6 R 7 or —OH, wherein: R