Patent ID: 9175075
Filing Date: 2015-11-03
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating retinal nerve fiber layer (RNFL) degeneration, comprising the step of administering to a mammal in need thereof an effective amount of a composition comprising an isolated antibody, wherein the isolated antibody comprises an antigen binding domain, said antibody capable of binding an epitope of a retinal guidance molecule (RGM), said antigen binding domain comprising a heavy chain variable domain having three complementary determining regions and a light chain variable domain having three complementary determining regions, wherein the three complementary determining regions of the heavy chain variable domain have the amino acid sequence of SEQ ID NO:57, SEQ ID NO:58 and SEQ ID NO:59 and the three complementary determining regions of the light chain variable domain have the amino acid sequence of SEQ ID NO:60, SEQ ID NO:61 and SEQ ID NO:62.