Patent ID: 6693098
Filing Date: 2004-02-17
Classification: A61P,C07C,C07D

Abstract:
A compound comprising Formula I: wherein:R1 and R3 are each independently in each occurrence optionally substituted aryl or optionally substituted heteroaryl; R2 is optionally substituted benzofuranyl or optionally substituted benzothiophenyl; R4 is â€”COCH or tetrazolyl; A is independently in each occurrence a single bond, â€”(CH2)pâ€”, â€”C&boxH;Câ€”, or â€”Câ‰¡Câ€”; B is independently in each occurrence â€”(CH2)qâ€”; m, p, and q are each independently in each occurrence an integer from 1 to 3 inclusive; n and r are each 0; wherein each aryl is independently phenyl, naphthyl, or indanyl, and is optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; and wherein each heteroaryl is independently oxazolyl, thiazolyl, pyridazinyl, pyrazinyl, thiophenyl, pyrimidinyl, pyridinyl, quinolinyl, isoquinolinyl, 1,3-benzodioxole, indol-5-yl, indol-4-yl, indol-2,5-diyl, N-alkyl-indolyl, or isoindolyl, and is optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; or an individual isomer, a racemic or non-racemic mixture of isomers, or a pharmaceutically acceptable salt or solvate thereof.