Patent ID: 7361668
Filing Date: 2008-04-22
Classification: A61P,C07D

Abstract:
1. A compound of formula I or II, or a pharmaceutically acceptable salt thereof, wherein R R R R R R6 and R7 are the same or different and each is independently amido, alkyl, alkenyl, alkynyl, ester, ether, aryl, aralkyl, heterocycle or an oxy derivative, thio derivative, acyl derivative, amino derivative, sulfonyl derivative or sulfinyl derivative; R6a is as defined for R6 except oxy derivative, thio derivative or amino derivative; R6b is as defined for R6 except oxy derivative; R6c is as defined for R6 except thio derivative; R6d is as defined for R6 or is hydrogen; R6e is as defined for R6; R7e is as defined for R7; R6f is as defined for R6 except for sulfonyl derivative; R6g is as defined for R6 except for sulfinyl derivative; R6h is as defined for R6; R7h is as defined for R7; R wherein the term “alkyl” is defined as selected from the group consisting of saturated, monovalent carbon radicals having straight, branched or cyclic moieties or combinations thereof and containing 1 to 20 carbon atoms and includes alkyl moieties optionally substituted by 1 to 5 substituents selected from the group consisting of halogen, hydroxy, thiol, amino, nitro, cyano; the term “alkenyl” is defined as selected from the group consisting of straight or cyclic, branched or unbranched, or unsaturated hydrocarbon radicals having at least one double bond and being optionally substituted by at least one substituent selected from the group consisting of halogen, hydroxy, thiol, amino, nitro, cyano, aryl and heterocycle; the term “alkynyl” is defined as selected from the group consisting of straight or cyclic, branched or unbranched, or unsaturated hydrocarbon radical containing at least one carbon-carbon triple bond and being optionally substituted by at least one substituent selected from the group consisting of halogen, hydroxy, thiol, amino, nitro, cyano, trimethylsilyl, aryl and heterocycle; the term “aryl” is defined as selected from the group consisting of an organic moiety derived from an aromatic hydrocarbon consisting of 1-3 rings and containing 6-30 carbon atoms by removal of one hydrogen, optionally substituted by 1 to 5 substituents selected from the group consisting of halogen, hydroxy, thiol, amino, nitro, cyano, acyl derivative, sulfonyl, sulfinyl, alkylamino, carboxy, ester, ether, amido, azido, sulfonic acid, sulfonamide, alkylsulfonyl, alkylsulfinyl, alkylthio, oxyester, oxyamido and aryl; the term “heterocycle” is defined as selected from the group consisting of an aromatic or non aromatic cyclic alkyl, alkenyl, or alkynyl moiety, having at least one O, S and/or N atom interrupting the carbocyclic ring structure in which optionally, one of the carbon of the carbocyclic ring structure may be replaced by a carbonyl and optionally substituted by 1 to 5 substituents selected from the group consisting of halogen, hydroxy, thiol, amino, nitro, cyano, 5-pyrimidinyl, 3-pyridinyl, 4-pyridinyl, 3-thienyl, 2-thienyl, 5-chloro-2-thienyl, 1,4-dithiepan-6-yl, thiomorpholino-4-yl, 8-thiabicyclo(3.2.1)oct-3-yl, 2-pyridinyl, 2-fluoro-3-pyridinyl, 6-fluoro-3-pyridinyl, 4-isoquinolinyl, 5-nitro-2-furyl, 1-methyl-1H-imidazol-2-yl, 1-pyrazolo[1,5-a]pyridine-3-yl-, 1-methyl-1H-pyrrol-2-yl), 4-piperidinyl, (2,2-dimethyl-1,3-dioxan-5-yl, tetrahydro-2H-thiopyran-4-yl, 1-(methylsulfonyl)-4-piperidinyl, and 3-pyridazinyl; or the term “heterocycle” is defined as an aromatic or non aromatic cyclic alkyl, alkenyl, or alkynyl moiety as defined above, having at least one O, S and/or N atom interrupting the carbocyclic ring structure and optionally, one of the carbon of the carbocyclic ring structure may be replaced by a carbonyl, wherein the aromatic heterocycles comprise pyridyl, furyl, pyrrolyl, thienyl, isothiazolyl, imidazolyl, benzimidazolyl, tetrazolyl, quinazolinyl, quinolizinyl, naphthyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolyl, isociuinolyl, isobenzofuranyl, benzothienyl, pyrazolyl, indolyl, indolizinyl, purinyl, isoindolyl, carbazolyl, thiazolyl, 1,2,4-thiadiazolyl, thieno(2,3-b)furanyl, furopyranyl, benzofuranyl, benzoxepinyl, isooxazolyl, oxazolyl, thianthrenyl, benzothiazolyl, benzoxazolyl, cinnolinyl, phthalazinyl, quinoxalinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl, phenothiazinyl, furazanyl, isochromanyl, indolinyl, xanthenyl, hypoxanthinyl, pteridinyl, 5-azacytidinyl, 5-azauracilyl, triazolopyridinyl, imidazolopyridinyl, pyrrolopyrimidinyl, and pyrazolopyrimidinyl optionally substituted by alkyl or as described above for the term “alkyl”, and wherein the non aromatic heterocycles comprise tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperidyl, piperazinyl, imidazolidinyl, morpholino, morpholinyl, 1-oxaspiro(4.5)dec-2-yl, pyrrolidinyl, 2-oxo-pyrrolidinyl, 8-thia bicyclo[3.2.1.]cyclooctanyl, 1,4-dithiepanyl, tetrahydro-2H-thiopyranyl, optionally be substituted with any suitable groups, including but not limited to one or more moieties selected from lower alkyl, or other groups as described above for the term “alkyl”; or the term “heterocycle” comprise bicylic, tricyclic and tetracyclic, spiro groups in which any of the above heterocylic rings is fused to one or two rings independently selected from an aryl ring, a cycloalkane ring, a cycloalkene ring or another monocyclic heterocyclic ring or where a monocyclic heterocyclic group is bridged by an alkylene group, comprising quinuclidinyl, 7-azabicyclo(2.2.1)heptanyl, 7-oxabicyclo(2.2.1)heptanyl, and 8-azabicyclo(3.2.1)octanyl; the term “aralkyl” represents a group of formula —R the term “ester” is defined as a group of formula —COO-R6a; the term amido” is defined as a group of formula —CONH2 or —CONHR6h or —CONR6hR7h; the term “oxy derivative” is defined as an —O-R6b group selected from the group consisting of alkoxy, alkenyloxy, alkynyloxy, acyloxy, esteroxy, amidooxy, alkylsulfonyloxy, alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, aryloxy, aralkoxy or heterocyclooxy; the term “thio derivative” is defined as an —S-R6e group selected from the group consisting of alkylthio, alkenylthio, alkynylthio and arylthio; the term “acyl derivative” is defined as a group of the formula R6d-CO— selected from the group consisting of hydrogen, formyl, acetyl, propionyl, isobutyryl, valeryl, lauroyl, heptanedioyl, cyclohexanecarbonyl, crotonoyl, fumaroyl, acryloyl, benzoyl, naphthoyl, furoyl, nicotinoyl, 4-carboxybutanoyl, oxalyl, ethoxalyl, cysteinyl, and oxamoyl; the term “amino derivative” is defined as an —NHR6e or —NR6eR7e group selected from the group consisting of mono- or di-alkyl-, alkenyl-, alkynyl- and arylamino or mixed amino; the term “sulfonyl derivative” is defined as a group of the formula —SO the term “sulfinyl derivative” is defined as a group of the formula —SO-R6g selected from the group consisting of alkylsulfinyl, alkenylsulfinyl, alkynylsulfinyl and arylsulfinyl.