Patent ID: 8986929
Filing Date: 2015-03-24
Classification: C12Q

Abstract:
1. A method for identifying a human subject as having a decreased tendency to develop Parkinsonism as an extrapyramidal symptom following treatment with an antipsychotic drug, said method comprising: obtaining a sample comprising genetic material of said subject; detecting, in said genetic material, the presence of at least one allele of the regulator of G-protein signaling 2 gene, comprising guanine at the SNP rs4606 thereby identifying the human subject as having a decreased tendency to develop Parkinsonism as an extrapyramidal symptom following treatment with an antipsychotic drug; and treating said human subject with a typical antipsychotic drug wherein detecting, in said genetic material, the presence of at least one allele of the regulator of G-protein signaling 2 gene is attained by a technique selected from the group consisting of: terminator sequencing, restriction digestion, allele-specific polymerase reaction, single-stranded conformational polymorphism analysis, genetic bit analysis, temperature gradient gel electrophoresis ligase chain reaction and ligase/polymerase genetic bit analysis.