Patent ID: 6200799
Filing Date: 2001-03-13
Classification: A61K,A61P,C07K,C12N

Abstract:
A replication-defective recombinant virus, said virus comprising:(a) an open reading frame (ORF) selected from the group consisting of:i) a dominant negative codon 116 mutant of a human RAS ORF;ii) a herpes simplex type I thymidine kinase ORF; andiii) a non-phosphorylatable retinoblastoma ORF; and(b) a promoter sequence selected from the group consisting of:i) a promoter comprising the human Major Intrinsic Protein gene promoter from -259 nt to +34 nt (SEQ ID NO:2); andii) a promoter comprising the human .beta.A3/A1-crystallin gene promoter from -345 nt to +45 nt (SEQ ID NO:4);wherein said ORF is under the control of said promoter sequence.