Patent ID: 9011880
Filing Date: 2015-04-21
Classification: A61P,C07K

Abstract:
1. A method of treating cancer in a mammal comprising: administering to the mammal a compound comprising an anti-cancer chemotherapeutic agent linked to an insulin-like growth factor-1 (IGF-1) receptor ligand, wherein the compound inhibits growth of the cancer in the mammal; wherein cancer cells in the mammal have IGF-1 receptors; wherein the IGF-1 receptor ligand is an IGF-1 receptor agonist that is a variant IGF-1 that has reduced binding affinity for soluble IGF-1 binding proteins compared to wild-type IGF-1 ;and (a) wherein the variant IGF-1 with reduced binding affinity to the soluble IGF-1 binding proteins comprises the polypeptide structure A