Patent ID: 6197782
Filing Date: 2001-03-06
Classification: A61P,C07D

Abstract:
A compound of structure IX: ##STR21##whereinR.sub.20 is: ##STR22##and R.sub.4 is(i) --CH(R.sub.d)--O--C(O)--Y-Z--(C(R.sub.e)(R.sub.f)).sub.p -T-Q,(ii) --C(O)--T--(C(R.sub.e)(R.sub.f)).sub.p -T-Q, or(iii) --C(O)--Z-(G-(C(R.sub.e)(R.sub.f)).sub.p -T-Q).sub.p ;wherein R.sub.d is a hydrogen, a lower alkyl, a cycloalkyl, an aryl, an arylalkyl, or a heteroaryl; Y is oxygen, sulfur, CH.sub.2 or NR.sub.i, wherein R.sub.i is a hydrogen or a lower alkyl; R.sub.e and R.sub.f are each independently a hydrogen, a lower alkyl, a haloalkyl, an alkoxy, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, an amino, an alkylamino, an amido, an alkylamido, a dialkylamino, a carboxylic acid, a carboxylic ester, a carboxamido or -T-Q, or R.sub.e and R.sub.f taken together with the carbons to which they are attached are a carbonyl, a cycloalkyl, a heterocyclic ring or a bridged cycloalkyl; p is an integer from 1 to 10; T is independently a covalent bond, oxygen, sulfur or [nitrogen] NH; G is a covalent bond, -T--C(O)--, --C(O)--T- or T; Z is a covalent bond, a lower alkyl, a haloalkyl, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, a heteroalkyl, an arylheterocyclic ring or (C(R.sub.e)(R.sub.f)).sub.p ; and Q is --NO or --NO.sub.2.