Patent ID: 8349293
Filing Date: 2013-01-08
Classification: A61K,A61P,B82Y

Abstract:
1. A method for diagnosing Alzheimer's disease (AD) by MRI comprising: (a) administering to a patient in need thereof an effective amount of metal nanoparticles which comprise a metallic core covered with a nonpolymeric layer selected from phosphate, phosphonate, phosphonate monoester, bisphosphonate, diphosphonate, gem-bisphosphonate, diphosphate, thiophosphate, thiophosphonate, polyphosphate, phosphinate, sulfonate, bisulfonate, hydroxamate, arginine hydroxamate, silane, silica derivative, silanetriol, trialkoxysilane, siloxane, amino acid, mercapto, dimercaptosuccinic acid, carboxylate, aliphatic dicarboxylic or polycarboxylic acid, cyclohexanetricarboxylic acid, cyclohexanehexacarboxylic acid, or catecholate, wherein said nonpolymeric layer is grafted to a group of formula and (b) conducting a step of MRI imaging the patient to detect the metal nanoparticles.