Patent ID: 8226981
Filing Date: 2012-07-24
Classification: A61K,A61P

Abstract:
1. A method of preparing a taste-masking oral dosage form, comprising: a. providing a first solution comprising a pharmaceutically active ingredient and a starch; b. heating said first solution to about 90° C. to dissolve the pharmaceutically active ingredient and the starch; c. providing a second solution comprising a hydrophilic polymer and a surfactant; d. blending the first and second solutions with continuous stirring to drop the temperature to lower than room temperature; e. precipitating out crystalline microparticles comprising the pharmaceutically active ingredient and the starch, wherein the diameter of said crystalline particles is about 150 to about 360 microns; and f. compressing said crystalline microparticles into a tablet having a porosity of about 30% to about 70% and a brittleness of less than 2%.