Patent ID: 8168827
Filing Date: 2012-05-01
Classification: A61P,C07C,C07D

Abstract:
1. An amide compound represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group, or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb′)m-, —NRa-(CRbRb′)m-, —NRa-(CRbRb′)m-O—, or —NRa′-(CRbRb′)m-NRa-; m is an integer of 0 to 4; Ra, Ra′, Rb, Rb′, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, and R17 may be the same or different, and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, an ammonium group, an alkyl group optionally having one or more substituents, an alkenyl group optionally having one or more substituents, an alkynyl group optionally having one or more substituents, a cycloalkyl group optionally having one or more substituents (optionally having one or more hetero atoms in the ring), a cycloalkylalkyl group optionally having one or more substituents (optionally having one or more hetero atoms in the ring), an aryl group optionally having one or more substituents, an aralkyl group optionally having one or more substituents, a heteroaryl group optionally having one or more substituents, a heteroarylalkyl group optionally having one or more substituents, or -ZR18, wherein: Z is —O—, —S(O)p—, —S(O)pO—, —NH—, —NR19-, —C(═O)—, —C(═O)O—, —C(═O)NH—, —C(═O)NR19-, —S(O)pNH—, —S(O)pNR19-, —NHC(═O)—, —NR19C(═O)—, —NHS(O)p-, or —NR19S(O)p-, p is an integer of 0 to 2, and R18 and R19 may be the same or different and each is a hydrogen atom, an alkyl group optionally having one or more substituents, an alkenyl group optionally having one or more substituents, an alkynyl group optionally having one or more substituents, a cycloalkyl group optionally having one or more substituents (optionally having one or more hetero atoms in the ring), a cycloalkylalkyl group optionally having one or more substituents (optionally having one or more hetero atoms in the ring), an aryl group optionally having one or more substituents, an aralkyl group optionally having one or more substituents, a heteroaryl group optionally having one or more substituents, a heteroarylalkyl group optionally having one or more substituents, or an acyl group, or R18 and R19 are optionally bonded to form a ring; or R3 and R4 are optionally bonded to form a carbon-carbon bond; or of R8, R9, R10, R11, R12, R13, R14, R15 and R16, those bonded to the adjacent carbon atom are optionally bonded to each other to form, together with the carbon atom constituting ring A, a saturated or unsaturated ring optionally having one or more hetero atoms in the ring formed; or when Y is —NRa-, Ra is optionally bonded to one of R12, R13, R14, R15, and R16 to form a ring together with the carbon atom constituting ring A, wherein R10 is other than an alkenyl group optionally having one or more substituents as defined above; or a pharmaceutically acceptable salt thereof.