Patent ID: 6828299
Filing Date: 2004-12-07
Classification: A61K,A61P,B82Y

Abstract:
A modified glycopeptide of formula II: wherein:R3 is â€”OH; R5 is hydrogen; R19 is hydrogen; R20 is â€”CH2â€”CH(OH)CH(OH)CH2â€”Yâ€”Rb(Z)x or â€”CH2â€”CH(OH)CH(OH)CH2â€”R17; within R20 moiety R17 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heteroaryl or heterocyclic; within moiety R20 Y is selected from the group consisting of oxygen, sulfur, â€”Sâ€”Sâ€”, NRcâ€”, â€”S(O)â€”, â€”SO2â€”, â€”NRcC(O)â€”, â€”OSO2â€”, â€”OC(O)â€”, â€”NRcSO2â€”, â€”C(O)NRcâ€”, â€”C(O)Oâ€”, â€”SO2NRcâ€”, â€”SO2Oâ€”, â€”P(O)(ORc)Oâ€”, â€”P(O)(ORc)NRcâ€”, â€”OP(O)(ORc)Oâ€”, â€”OP(O)(ORc)NRcâ€”, â€”OC(O)Oâ€”, â€”NRcC(O)Oâ€”,â€”NRcC(O)NRcâ€”, â€”OC(O)NRcâ€”, â€”C(&boxH;O)â€”and â€”NRcSO2NRcâ€”; within R20 moiety each Z is independently selected from the group consisting of hydrogen, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic and x is 1 or 2; within Y moiety Rb is selected from the group consisting of a covalent bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene and substituted alkynylene, provided Rb is not a covalent bond when Z is hydrogen; each Rc is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heteroaryl, heterocyclic and â€”C(O)Rd; within Rc moiety each Rd is independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heteroaryl and heterocyclic; and or a pharmaceutically acceptable salt or a stereoisomer thereof.