Patent ID: 8299039
Filing Date: 2012-10-30
Classification: A61P,C07K,C12N,Y10T

Abstract:
1. A method of reducing the plasma level of insulin-like growth factor-1 in an animal comprising: identifying an animal in need of a reduction in said animal's plasma level of insulin-like growth factor-1; and administering to said animal in need thereof a modified oligonucleotide 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 nucleobases in length, wherein said modified oligonucleotide is fully complementary over the entirety of said modified oligonucleotide with a human growth hormone receptor RNA, wherein said modified oligonucleotide comprises at least one modified internucleoside linkage, modified sugar moiety, or modified nucleobase, and wherein the expression of growth hormone receptor in said animal is inhibited and said animal's plasma level of insulin-like growth factor-1 is reduced.