Patent ID: 8362261
Filing Date: 2013-01-29
Classification: C07D,Y02P

Abstract:
1. A process for preparing a pyridyl substituted pyrazole derivative of formula (I) in which R R R comprising (A) reacting an acetylketone of formula (II) in which R X is halogen, with a hydrazinopyridine of formula (III) in which R in the presence of a solvent, to give a 1-pyridyl-substituted dihydro-1H-pyrazole of formula (IV) in which X, R (B) optionally without isolating, in the presence of a solvent, reacting the compound of formula (IV) by eliminating water, to give a 1-pyridyl-substituted trihalomethylpyrazole of formula (V) in which X, R (C) reacting the compound of formula (V) under an acidic or basic condition, optionally in the presence of a catalyst, to give a pyrazolecarboxylic acid of formula (VI) in which R (D) removing the protecting group R in which R (E) reacting the compound of formula (VII) with a halogenating agent, in the presence of a solvent, to give an acid halide; and optionally further reacting the halide with an alcohol to give the compound of formula (I).