Patent ID: 6824991
Filing Date: 2004-11-30
Classification: A61K,A61P,C07K

Abstract:
A method of screening for a compound that interferes with the association of a human Bad interacting polypeptide with human Bad, said human Bad comprising an isolated human Bad polypeptide encoded by a nucleic acid molecule comprising the nucleotide sequence shown in SEQ ID NO; 1 or a nucleotide sequence that has greater than 85% nucleotide identify to the nucleotide sequence shown in SEQ ID NO:1 wherein said screening comprises contacting human Bad, or a human Bad derived fragment which retains the ability to interact with a human Bad interacting polypeptide, in the presence of an interacting polypeptide with a sample suspected of containing a compound capable of interfering with the human Bad polypeptide association and determining the interaction between human Bad and human Bad interacting polypeptide thereby screening for a compound which interferes with the association of a human Bad interacting polypeptide with human Bad.