Patent ID: 6114394
Filing Date: 2000-09-05
Classification: A61K,A61P,C07C

Abstract:
A method of protecting mammalian cells from deleterious cellular effects caused by exposure to ionizing radiation comprising contacting said cells with a protective amount of a polyamine of the formulaRHN (CH.sub.2).sub.m --NH--(CH.sub.2).sub.n --NH--(CH.sub.2).sub.m --NHRwhereinm is an integer from 2 to 4n is an integer from 3 to 10 andR is (CH.sub.2).sub.p --ArwhereinAr is phenyl or naphthyl andp is an integer from 0 to 2,with the proviso that when n=8 and m=3, p cannot be 1;or the pharmaceutically acceptable addition salts thereof.