Patent ID: 8710228
Filing Date: 2014-04-29
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) wherein R H, N[(C R R H, halogen, (C OH, O—R″, NH NHR″, NR″R″ or NH—C(O)—R″; R H, halogen, hydroxy, CN, (C R H, halogen, CN, NO (C (C CH(OH)—(C NH NH—SO NH—SO NH—C(O)—(C C(O)N[(C C(O)OH, or C(O)O—(C R R H, R′, (C (C (C (C (C (C (C (C (C (C (C (C C(O)O—(C C(O)OR′ C(O)R′, C(O)NH—(C C(O)NHR′, C(O)N[(C C(O)N[(C C(O)—(C C(O)O(C R R H, halogen, CN, NO (C O—(C (C CH(OH)—(C NH NH—SO NH—SO SO NH—C(O)—(C C(O)N[(C C(O)OH, or C(O)O—(C R n is 1, 2, 3 or 4; m is 3; and L is O or O—(C R′ is (C (C (C R″ is (C (C (C (C or (C R (C (C (C wherein in residues R wherein in residues R wherein in residues R3, R6 and R6′ as (C pharmaceutically acceptable salt thereof; with the proviso that the following compounds are excluded: cis-4-(isoquinolin-6-yloxy)-cyclohexylamine and trans-4-(isoquinolin-6-yloxy)-cyclohexylamine.