Patent ID: 7034177
Filing Date: 2006-04-25
Classification: C07F

Abstract:
1. A method of producing cyanoalkyl tetraalkylphosphordiamidite comprising: a) reacting phosphorus trihalide with cyano-containing reagent selected from the group consisting of cyanoalkanol and cyanoalkoxytrialkylsilane to form cyanoalkylphosphordihalidite; b) reacting the cyanoalkylphosphordihalidite with a dialkylamine to form cyanoalkyl tetraalkylphosphordiamidite and an amine hydrohalide byproduct at least a portion of which is in the form of a precipitate; c) removing the amine hydrohalide precipitate by filtration to form a filtrate which may contain dissolved amine hydrohalide; and d) treating the filtrate with a substance capable of removing any dissolved amine hydrohalide from the filtrate selected from the group consisting of adsorbents and polymer-supported neutralizing agents.