Patent ID: 9169204
Filing Date: 2015-10-27
Classification: A61K,A61P,C07B,C07C

Abstract:
1. A pharmaceutical ophthalmological composition for use in treating a visual disorder due to a deficiency of 11-cis-retinal in an eye of a human subject, comprising: a synthetic retinyl ester that is a 9-cis-retinyl ester or an 11-cis-retinyl ester, wherein when the synthetic retinyl ester is administered to the human subject a functional opsin/chromophore complex is formed in the eye; and, a pharmaceutically acceptable vehicle; wherein the 9-cis-retinyl ester has a structure as represented by Formula I or the 11-cis-retinyl ester has a structure as represented by Formula II, wherein A in each formula is CH wherein the ester substituent is selected from the group consisting of formate, acetate, propionate, butyrate, valerate, caproate, heptanoate, caprylate, pelargonate, caprate, oxalate, malonate, succinate, fumarate, malate, glutarate, adipate, pimelate, suberate, azelate, sebacate, citrate, oxaloacetate, and ketoglutarate.