Patent ID: 8277810
Filing Date: 2012-10-02
Classification: A61K,A61N,A61P,C07K

Abstract:
1. A human monoclonal antibody that is capable of specifically binding to human CD40 expressed on the surface of a human CD40-expressing cell, said monoclonal antibody being free of significant agonist activity, whereby, when said monoclonal antibody binds to CD40 expressed on the surface of said cell, the growth or differentiation of said cell is inhibited, wherein said antibody is selected from the group consisting of: a) the monoclonal antibody CHIR-12.12 produced by the hybridoma cell line deposited with the ATCC as Patent Deposit No. PTA-5543; b) a monoclonal antibody comprising a light chain variable domain comprising residues 21-132 of SEQ ID NO:2; c) a monoclonal antibody comprising a heavy chain variable domain comprising residues 20-139 of SEQ ID NO:4; d) a monoclonal antibody comprising an amino acid sequence selected from the group consisting of: (i) residues 21-239 of SEQ ID NO:2; (ii) SEQ ID NO:2; (iii) residues 20-469 of SEQ ID NO:4; (iv) SEQ ID NO:4; (v) residues 20-469 of SEQ ID NO:5; (vi) SEQ ID NO:5; (vii) residues 21-132 of SEQ ID NO:2 and residues 20-139 of SEQ ID NO:4; (viii) residues 21-239 of SEQ ID NO:2 and residues 20-469 of SEQ ID NO:4; (ix) residues 21-239 of SEQ ID NO:2 and residues 20-469 of SEQ ID NO:5; (x) SEQ ID NO:2 and SEQ ID NO:4; and (xi) SEQ ID NO:2 and SEQ ID NO:5; e) a monoclonal antibody that is an antigen-binding fragment of a monoclonal antibody of any one of preceding items a)-d), wherein said fragment retains the capability of specifically binding to said human CD40, and wherein said fragment is selected from the group consisting of a Fab fragment, an F(ab′) f) a conjugated form of the monoclonal antibody of any one of preceding items a)-e).