Patent ID: 6753449
Filing Date: 2004-06-22
Classification: C07B,C07C,C40B,Y10T

Abstract:
A composition comprising an insoluble support covalently attached to a linker moiety, the linker moiety comprising a group represented by the formula: wherein n is 0, 1 or 2; X is CH2, O, S, or NR, in which R is optionally substituted alkyl or optionally substituted aryl; Y is a leaving group, ORâ€², NHRâ€², or SRâ€², in which Râ€² is a positively-charged ion, optionally substituted alkyl or optionally substituted aryl; and R1-R5 are each independently selected from the group consisting of H, optionally substituted alkyl or optionally substituted aryl, nitro, alkoxy, aryloxy, cyano, azido, halogen, optionally substituted thioalkyl and optionally substituted thioaryl, and further wherein at least one of R1-R5 is covalently attached to the insoluble support.