Patent ID: 6100283
Filing Date: 2000-08-08
Classification: A61K,A61P,C07D

Abstract:
A pro-drug of a compound having the structural formula I ##STR26## wherein R is selected from the group consisting of hydrogen, hydroxyalkyl and benzyl and phenyl groups which are unsubstituted or substituted by at least one substituent in the benzene ring selected from the group consisting of hydroxy, alkoxy, NO.sub.2, N.sub.3, NR.sub.5 R.sub.6 (R.sub.5 and R.sub.6 each being independently hydrogen, alkyl or alkoxy), NHCOR.sub.3 (R.sub.3 being alkyl or aryl), CO.sub.2 R.sub.4 (R.sub.4 being H or alkyl), an amide, tetrazole, alkyl, hydroxyalkyl, CW.sub.3 or W (W being halogen), and CN, andR' is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, acyl or an optionally substituted phenyl group having the structural formula III: ##STR27## wherein R.sub.7, R.sub.8 and R.sub.10 are each selected independently from the group consisting of H, hydroxy, alkoxy, NO.sub.2, NO.sub.3, NR.sub.5 R.sub.6 (R.sub.5 and R.sub.6 each being independently hydrogen, alkyl or alkoxy), NHCOR.sub.3 (R.sub.3 being alkyl or aryl), CO.sub.2 R.sub.4 (R.sub.4 being H or alkyl), an amide, tetrazole, alkyl, hydroxyalkyl, CW.sub.3 or W (W being halogen), and CNwherein the pro-drug form is a phosphate derivative of said compound.