Patent ID: 6124283
Filing Date: 2000-09-26
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having the formula (I) ##STR56## wherein X is N;Y is NR.sub.2 CH.sub.2, CH.sub.2 --NR.sub.2, NR.sub.2 --CO, CO--NR.sub.2 or NR.sub.2 SO.sub.2 ;R.sub.1 is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl;R.sub.2 is H or C.sub.1 -C.sub.6 alkyl;R.sub.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or (CH.sub.2).sub.n -aromatic ring, wherein the aromatic ring is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and wherein the aromatic ring may be mono- or di-substituted with R.sub.4 and/or R.sub.5 ;R.sub.4 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halogen, CN, CF.sub.3, OH, C.sub.1 -C.sub.6 alkoxy, NR.sub.6 R.sub.7, OCF.sub.3, SO.sub.3 CH.sub.3, SO.sub.3 CF.sub.3, SO.sub.2 NR.sub.6 R.sub.7, phenyl, phenyl-C.sub.1 -C.sub.6 alkyl, phenoxy, C.sub.1 -C.sub.6 alkyl phenyl, C.sub.1 -C.sub.6 alkyl-heterocyclic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO.sub.2, an optionally substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO.sub.2 wherein the optional substituent(s) may be selected from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl and phenyl-C.sub.1 -C.sub.6 alkyl; or COR.sub.8 ;R.sub.5 is H, OH, CF.sub.3, OCF.sub.3, halogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy;R.sub.6 is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl;R.sub.7 is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl;R.sub.8 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, CF.sub.3, NR.sub.6 R.sub.7, phenyl, or a heterocyclic ring containing one or two heteroatoms or substituted heteroatoms selected from N, O, S, SO and SO.sub.2 ;n is 0-4;as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof.