Patent ID: 6339087
Filing Date: 2002-01-15
Classification: C07D

Abstract:
A compound selected from compounds of Formula (I): wherein:R1 and R2 are, independently of each other, hydrogen or alkyl; m is an integer from 0 to 3; F is alkylene, alkenylene or a bond; each R is independently hydrogen or alkyl, or R together with R4 and the atoms to which they are attached form a carbocycle; R3 is H; R4 is alkyl, (C3-C6)cycloalkyl or hydroxyalkyl; E is â€”SO2N(R5)â€”, â€”N(R6)SO2N(R5)â€”, â€”N(R6)C(O)Oâ€”, â€”OC(O)N(R5)â€” or â€”N(R6)SO2, wherein R5 and R6 are individually H or alkyl or N(R5) or N(R6) together with C(R4) form a heterocycloamino moiety; provided that when E is â€”SO2N(R5)â€” or â€”N(R6)SO2N(R5)â€”, then m>0; Ar is (C6-C10)aryl, optionally substituted with one, two or three alkyl, alkenyl, halo, alkoxy, haloalkoxy, (C6-C10)aryl, phenoxy, (C5-C10)heteroaryl, â€”C(O)(alkyl), â€”C(O) (optionally substituted phenyl), â€”SO2(alkyl), â€”SO2NRâ€²Râ€³, wherein Râ€² and Râ€³ are hydrogen or alkyl; acylamino, acylaminoalkyl, (alkylene)NRâ€²Râ€³, methylenedioxy, hydroxy, hydroxyalkyl, NRâ€²Râ€³, â€”CONRâ€²Râ€³, -(alkylene)-CONRâ€²Râ€³, COORâ€², (alkylene)CO2Râ€², CN, alkylthio, NO2, haloalkyl, (alkylene)NRâ€²SO2Râ€²â€³, â€”NRâ€²SO2Râ€²â€³ wherein Râ€²â€³ is alkyl or NRâ€²Râ€³; or a combination thereof; Ar1 is (C6-C10)aryl, optionally substituted with one, two or three alkyl, (C6-C10)heteroalkyl, alkoxy, halo, haloalkyl, haloalkoxy, alkylthio, methylene dioxy, nitro; NRâ€²Râ€³ or a combination thereof; Q is C1-C6 alkylene; or a pharmaceutically acceptable salt thereof.