Patent ID: 6555574
Filing Date: 2003-04-29
Classification: A61P,C07D

Abstract:
A 4-oxybenzopyran derivative of the formula (I) wherein,R1 and R2 represent each independently a hydrogen atom; a C1-6 alkyl group in which said alkyl group may be optionally substituted with a halogen atom, a C1-6 alkoxy group or a hydroxyl group; of a phenyl group in which said phenyl group may be optionally substituted with a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C1-6 alkyl group or a C1-6 alkoxy group; R3 represents a hydroxyl group or a C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 akylcarbonyl group, a C1-6 alkylaminocarbonyl group or a di-C1-6 alkylaminocarbonyl group in which said C1-6 alkyl group, said C1-6 alkylcarbonyl group, said C1-6 alkylaminocarbonyl group and said di-C1-6 alkylaminocarbonyl group may be each optionally substituted with a halogen atom, a C1-6 alkoxy group, a C1-6 alkoxy group substituted by a halogen atom; a carboxyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group, or an aryl group or a heteroaryl group, in which said aryl group and said heteroaryl group may be optionally substituted with (R9)r, in which R9 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a C1-6 alkyl group substituted by a halogen atom or a C1-6 alkoxy group; a C1-6 alkoxy group, a C1-6 alkoxy group substituted by a halogen atom; or R9 represents a nitro group, a cyano group, a formyl group, a formamide group, an amino group, a C1-6 alkylamino group, a di-C1-6 alkylamino group, a C1-6 alkylcarbonylamino group, A C1-6 alkylsulfonylamino group, an aminocarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, a C1&nequiv;alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminosulfonyl group, a C1-6 alkylsulfonyl group, a carboxyl group or an arylcarbonyl group, r represents an integer of 1-3 and each R9 may same or different if r represents 2 or 3; or R4 represents an aryl group or a heteroaryl group in which said aryl group and said heteroaryl group may be optionally substituted with (R10)q in which R10 has the same meaning as R9, q represents an integer of 1-3, and each R10 may be same or different if q represents 2 or 3; n represents an integer of 0-4; X represents â€”C(&boxH;O)NR7â€”, â€”NR8â€”, â€”NHC(&boxH;O)NHâ€” or â€”S(O)2NHâ€” (in which R7 and R8 represent each independently a hydrogen atom or a C1-6 alkyl group); R5 represents a hydrogen atom; or a group of the formula: in which R12 represents a hydrogen atom; a halogen atom; a C1-6 alkyl group in which the alkyl group may be optionally substituted with a halogen atom or a C1-6 alkoxy group; a C1-6 alkoxy group in which said alkoxy group may be optionally substituted with a halogen atom; a phenyl group in which said phenyl group may be optionally substituted with a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group or R12 represents a hydroxyl group, a nitro group, a cyano group, a formyl group, a formamide group, an amino group, a C1-6 alkylamino group, a di-C1-6 alkylamino group, a C1-6 alkylcarbonylamino group, a C1-6 alkylsulfonylamino group, an aminocarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminosulfonyl group, a C1-6 alkylsulfonyl group, a carboxyl group or an arylcarbonyl group, m represents an integer of 1-3, and each R12 may be same or different if m represents 2 or 3, and R13 represents a hydrogen atom or a C1-6 alkyl group; andR6 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof.