Patent ID: 6403816
Filing Date: 2002-06-11
Classification: A61K,C07J

Abstract:
A betulinic acid derivative of structure (3) whereR is H; R1 is H or Br; R2 is O, NNHC6H5, NHNHC6H5, NHNHC6H4(OH3)(4), N&boxH;CHC6H3F2 (3,4), N&boxH;CHC6H3F3 (2,4),NOH, NNHCOC6H4OH(2) or NOCH2C6H4NO2 (4); R3 is H, â€”CH2CH2COOCH3, â€”COCH&boxH;CH2, or 3-Deoxydihydrobetulinic acid; and R4 is CH2&boxH;Câ€”CH3 CH(CH3)2 or BrCH2C(Br)CH3 with the proviso that the following compounds are excluded; R2 is not O or NOH, when R, R1 and R3 are H, and R4 is CH2&boxH;CCH3 or CH(CH3)2.