Patent ID: 9193698
Filing Date: 2015-11-24
Classification: C07D

Abstract:
1. A process for preparing fluoxastrobin, comprising: (i) reacting benzofuran-3(2H)-one O-methyl oxime (10) with an alkyl nitrite in the presence of an acid to form (3E)-2,3-benzofuran-dione O (ii) reacting the (3E)-2,3-benzofuran-dione O (iii) reacting the (3E)-benzofuran-2,3-dione O (iv) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X (v) reacting the (E)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (14) with 2-chlorophenol, in the presence of a solvent and optionally in the presence of a base, to form fluoxastrobin: