Patent ID: 6096714
Filing Date: 2000-08-01
Classification: A61P,C07H,Y02A

Abstract:
A compound selected from the group consisting of ##STR12## wherein X is selected from the group consisting of --CH.sub.2 --, --SO.sub.2 and --O--, Y is --(CH.sub.2).sub.m --(CH.dbd.CH.sub.n)--(CH.sub.2).sub.o --, m+N+.ltoreq.8, n is 0 or 1, Ar is aryl or heterocycle aryl, the aryl and heterocycle aryl being unsubstituted or substituted with at least one substituent selected from the group consisting of --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl and alkynyl of up to 12 carbon atoms, optionally substituted with at least one halogen, alkylthio, alkenylthio and alkynylthio of up to 12 carbon atoms optionally substituted with at least one halogen, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms optionally substituted with at least one halogen, ##STR13## and ##STR14## are individually hydrogen or alkyl of 1 to 12 carbon atoms, R.sub.3 is selected from the group consisting of 1 to 12 carbon atoms, aryl and heteroaryl, W is hydrogen or ##STR15## R"" is alkyl of 1 to 8 carbon atoms or Ar is unsubstituted or substituted aryl, the substituents being at least one member of the group consisting of --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl, S-alkynyl, N-alkyl, N-alkenyl and N-alkynyl containing up to 12 carbon atoms optionally substituted by at least one halogen, Z is hydrogen or acyl of an organic carboxylic acid and non-toxic, pharmaceutically acceptable acid addition salts of the compound of Formula I.