Patent ID: 6262078
Filing Date: 2001-07-17
Classification: C07D

Abstract:
A method for treating a mammal having a disease state which is treatable by administration of a sodium channel blocker, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula I: ##STR12##where:R.sup.1 is (C1-4)alkyl, -(CH.sub.2).sub.m cycloalkyl, or -(CH.sub.2).sub.m NR.sup.7 SO.sub.2 R.sup.9 ;where:m is 1 to 3;R.sup.2 and R.sup.6 are each independently (C1-4)alkyl or halogen;R.sup.3 and R.sup.5 are each independently hydrogen or (C1-4)alkyl;R.sup.4 is hydrogen, (C1-4)alkyl, hydroxy, (C1-4)alkyloxy, fluoro(C1-4)alkyloxy, halogen, or phenyl or mono- or di-substituted phenyl, the substituents selected from (C1-4)alkyloxy, amino, nitro, or acetylamino;R.sup.7 and R.sup.8 are each independently hydrogen or (C1-4)alkyl; andR.sup.9 is (C1-4)alkyl;or a pharmaceutically acceptable salt or N-oxide thereof, as an individual isomer or as a racemic or non-racemic mixture of isomers.