Patent ID: 6319498
Filing Date: 2001-11-20
Classification: A61K,A61P,C07K

Abstract:
An amyloid modulator compound having the structure: ##STR11##wherein Xaa is an amyloidogenic protein, or peptide fragment thereof, and A is a modifying group comprising a cis-decalin group, a cholanoyl structure, a cholyl group, a diethylene-triaminepentaacetyl group, a (-)-menthoxyacetyl group, a fluorescein-containinag group, or an N-acetylneuraminyl group, covalently attached to the .alpha.-amino group at the amino-terminus of the amyloidogenic protein, or peptide fragment thereof, such that the compound modulates the aggregation of natural amyloid proteins or peptides when contacted with the natural amyloidogenic proteins or peptides.