Patent ID: 6833376
Filing Date: 2004-12-21
Classification: A61K,A61P,C07D

Abstract:
A 5-aminoalkyl and 5-aminocarbonyl substituted indole compound having the formula whereinR1 is â€”(CH2)n-1-CONR10R11, â€”(CH2)n-NR10R11 or wherein R10 and R11 are independently selected from hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkenyl, C3-8-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, aryl-C1-6-alkyl, aryl, acyl, amino-C1-6-alkyl and mono- or di-C1-6-alkylamino-C1-6-alkyl, R12 is hydrogen, or C1-6-alkyl, n is 1 to 3 and q is 2 to 5;G is C, or CH; the dotted line meaning a bond when G is C, and the dotted line meaning no bond when G is CH, N; Ar is phenyl optionally substituted with one or more substituents independently selected from halogen, C1-6-alkyl, C1-6-alkoxy, hydroxy, trifluoromethyl and cyano, or Ar is 2-thienyl, 3-thienyl, 2-furanyl, 3-furanyl, 2-thiazolyl, 2-oxazolyl, 2-imidazolyl, 2-pyridyl, 3-pyridyl, or 4-pyridyl; R2, R3, R4 and R5 are independently selected from hydrogen, C1-6-alkyl, C1-6-alkoxy, hydroxy, halogen trifluoromethyl, nitro, cyano, amino, C1-6-alkylamino and C1-6-dialkylamino; R6 is hydrogen, or C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, C2-6-alkenyl or C2-6-alkenyl, which may optionally be substituted with one or two hydroxy groups, any hydroxy group present being optionally esterified with an aliphatic carboxylic acid having from two to twenty-four carbon atoms inclusive, or R6 is a group of the Formula II or III: wherein m is an integer from 2-6;W is O or S; U is N or CH; Z is â€”(CH2)p, p being 2 or 3, or Z is â€”CH&boxH;CHâ€” or 1,2-phenylene optionally substituted with halogen or trifluoromethyl, or Z is â€”COCH2- or â€”CSCH2-; V is O, S, CH2, or NR9, wherein R9 is hydrogen, or C1-6-alkyl, C2-6-alkenyl or C2-6-alkenyl, which may optionally be substituted with one or two hydroxy groups, or a C3-8-cycloalkyl or C3-8-cycloalkyl-C1-6-alkyl group; X is N, C, or CH; Y is N, C, or CH; provided at least one of X and Y s N; and R7 is hydrogen, or C1-6-alkyl; or a pharmaceutically acceptable acid addition salt thereof.