Patent ID: 9181340
Filing Date: 2015-11-10
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal antibody or antigen binding fragment thereof, comprising a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3, and a light chain variable region comprising a light chain complementarity determining region (LCDR)1, a LCDR2, and a L-CDR3, of the amino acid sequences set forth as one of: (a) SEQ ID NO: 1 and SEQ ID NO: 6, respectively (L2); (b) SEQ ID NO: 2 and SEQ ID NO: 7, respectively (L1); (c) SEQ ID NO: 3 and SEQ ID NO: 8, respectively (L3); (d) SEQ ID NO: 4 and SEQ ID NO: 9, respectively (L5); or (e) SEQ ID NO: 5 and SEQ ID NO: 10, respectively (1D2); and wherein the monoclonal antibody or antigen binding fragment specifically binds to TEM8.