Patent ID: 7973044
Filing Date: 2011-07-05
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method for treating a condition in a patient said condition selected from the group consisting of asthma, inflammatory bowel disease, ulcerative colitis, Crohn's disease, multiple sclerosis, rheumatoid arthritis, graft versus host disease, and organ or graft rejection, which method comprises administering a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of compound of formula IIa: or a pharmaceutically acceptable salt thereof, wherein ring A forms a pyrimidine ring, optionally substituted with 1 or 2 substituents selected from the group consisting of R R R Q is —NR R R X is selected from the group consisting of hydroxyl, alkoxy, substituted alkoxy, alkenoxy, substituted alkenoxy, cycloalkoxy, substituted cycloalkoxy, cycloalkenoxy, substituted cycloalkenoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy and —NR″R″, wherein each R″ is independently selected from the group consisting of hydrogen, R wherein R R R R R R R R R R R R R R R R wherein R R R alkoxy has the formula “alkyl-O—”, wherein alkyl is R substituted alkoxy has the formula “substituted alkyl-O—”, wherein substituted alkyl is R cycloalkoxy has the formula “—O-cycloalkyl”, wherein cycloalkyl is R substituted cycloalkoxy has the formula “—O-substituted cycloalkyl”, wherein substituted cycloalkyl is R alkenoxy has the formula “alkenyl-O—”, wherein alkenyl is R substituted alkenoxy has the formula “substituted alkenyl-O—”, wherein substituted alkenyl is R cycloalkenoxy has the formula “cycloalkenyl-O—”, wherein cycloalkenyl is R substituted cycloalkenoxy has the formula “substituted cycloalkenyl-O—”, wherein substituted cycloalkenyl is R aryloxy has the formula “aryl-O—”, wherein aryl is R substituted aryloxy has the formula “substituted aryl-O—”, wherein substituted aryl is R heteroaryloxy has the formula “—O-heteroaryl”, wherein heteroaryl is R substituted heteroaryloxy has the formula “—O-substituted heteroaryl”, wherein substituted heteroaryl is R heterocyclyloxy has the formula “—O-heterocyclic”, wherein heterocyclic is R substituted heterocyclyloxy has the formula “—O-substituted heterocyclic”, wherein substituted heterocyclic is R aryloxyaryl has the formula “aryl-O-aryl”, wherein each aryl is R substituted aryloxyaryl has the formula “aryl-O-aryl”, wherein each aryl is R acyl is R acylamino is selected from the group —C(O)NRR thiocarbonylamino is selected from the group —C(S)NRCR acyloxy is selected from R oxysulfonyl has the formula R amino has the formula —NH substituted amino has the formula —NR amidino has the formula H alkyl amidino is “alkylHNC(═NH)—”, wherein alkyl is R thioamidino has the formula RSC(═NH)—; aminoacyl has the formula —NRC(O)R aminosulfonyl having the formula —NRSO aminocarbonyloxy having the formula —NRC(O)O—R aminosulfonyloxy has the formula —NRSO oxycarbonylamino has the formula —OC(O)NH oxythiocarbonylamino has the formula —OC(S)NH aminocarbonylamino has the formula —NR aminothiocarbonylamino has the formula —NR aminosulfonylamino has the formula —NR oxysulfonylamino has the formula —OSO halogen is fluoro, chloro, bromo or iodo; guanidino has the formula —NR guanidinosulfone has the formula —NRC(═NR)NRSO thioalkyl having the formula “—S-alkyl”, wherein alkyl is R substituted thioalkyl has the formula “—S-substituted alkyl”, wherein substituted alkyl is R thiocycloalkyl has the formula “—S-cycloalkyl”, wherein cycloalkyl is R substituted thiocycloalkyl has the formula “—S-substituted cycloalkyl”, wherein substituted cycloalkyl is R thioaryl has the formula “—S-aryl”, wherein aryl is R substituted thioaryl has the formula “—S-substituted aryl”, wherein substituted aryl is R thioheteroaryl has the formula “—S-heteroaryl”, wherein heteroaryl is R substituted thioheteroaryl has the formula “—S-substituted heteroaryl”, wherein substituted heteroaryl is R thioheterocyclic has the formula “—S-heterocyclic”, wherein heterocyclic is R substituted thioheterocyclic has the formula “—S-substituted heterocyclic”, wherein substituted heterocyclic is R wherein each R is independently hydrogen or R each R each R each R