Patent ID: 6509346
Filing Date: 2003-01-21
Classification: A61P,C07D

Abstract:
A method of treating a disease associated with aberrant leukocyte recruitment and/or activation mediated by chemokine receptor function, comprising administering to a subject in need thereof an effective amount of a compound represented by the following structural formula: or physiologically acceptable salts thereof, wherein:n is an integer from one to four; M is >NR2 or >CR1R2; R1 is â€”H, â€”OH, a halogen, an aliphatic group, â€”O-(aliphatic group), â€”O-(substituted aliphatic group), â€”SH, â€”S-(aliphatic group), â€”S-(substituted aliphatic group), â€”OC(O)-(aliphatic group), â€”Oâ€”C(O)-(substituted aliphatic group), â€”C(O)O-(aliphatic group), â€”C(O)O-(substituted aliphatic group), â€”COOH, â€”CN, â€”COâ€”NR3R4, or R1 is a covalent bond between the ring atom at M and an adjacent carbon atom in the ring which contains M; R2 is â€”OH, an acyl group, a substituted acyl group, â€”NR5R6, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; R3, R4, R5 and R6 are independently â€”H, an acyl group, a substituted acyl group, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; or R1 and R2, R3 and R4, or R5 and R6 taken together with the atom to which they are bonded, form a substituted or unsubstituted non-aromatic carbocyclic or heterocyclic ring; said acyl group is an aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl; Z is represented by: â€ƒwherein: X1 is â€”Oâ€”, â€”Sâ€”, â€”CH2â€”, â€”CH2â€”CH2â€”, â€”CH2â€”Sâ€”, â€”Sâ€”CH2â€”, â€”Oâ€”CH2â€”, â€”CH2â€”Oâ€”, â€”NRcâ€”CH2â€”, â€”CH2â€”NRcâ€”, â€”SOâ€”CH2â€”, â€”CH2â€”SOâ€”, â€”S(O)2â€”CH2â€”, â€”CH2â€”S(O)2â€”, â€”CH&boxH;CHâ€”, â€”NRâ€”COâ€” or â€”COâ€”NRcâ€”; Rc is â€”H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group or a substituted benzyl group; R40 is â€”COOH, â€”NO2, a substituted aliphatic group, an aromatic group, a substituted aromatic group, â€”NR24R25, â€”CONR24R25, Q-(aliphatic group), Q-(substituted aliphatic group), â€”O-(substituted aliphatic group), â€”O-(aromatic group), â€”O-(substituted aromatic group), â€”(O)uâ€”(CH2)tâ€”C(O)OR20, â€”(O)uâ€”(CH2)tâ€”OC(O)R20, â€”(O)uâ€”(CH2)tâ€”C(O)â€”NR21R22 or â€”(O)uâ€”(CH2)tâ€”NHC(O)Oâ€”R20; R20, R21 or R22 are independently â€”H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group or a non-aromatic heterocyclic group; or R21 and R22 taken together with the nitrogen atom to which they are bonded, form a non-aromatic heterocyclic ring; Q is â€”NR24C(O)â€”, â€”NR24S(O)2â€” or â€”C(O)Oâ€”; R24 and R25 are independently â€”H, â€”OH, an aliphatic group or a substituted aliphatic group; u is zero or one; and t is an integer from zero to 3.