Patent ID: 7875723
Filing Date: 2011-01-25
Classification: C07D

Abstract:
1. A process for the preparation of S-omeprazole magnesium from a racemic omeprazole starting material comprising the steps of: resolving the racemic omeprazole into R-omeprazole and S-omeprazole enantiomers using a chiral column chromatograph comprising a chiral stationary phase and a one-component mobile phase in order to elute a fraction of S-omeprazole in the mobile phase: concentrating the fraction of S-omeprazole in the eluted mobile phase; reacting the S-omeprazole in the eluted mobile phase with a source of magnesium to produce S-omeprazole magnesium; and precipitating the S-omeprazole magnesium using a substantially nonpolar organic solvent.