Patent ID: 7354759
Filing Date: 2008-04-08
Classification: A61K,C07K

Abstract:
1. A therapeutic vaccine for a chronic B-lymphoproliferative disorder comprising a DNA segment coding for a hypervariable region (VH-CDR3) of the idiotypic immunoglobulin expressed on B-cells of a subject afflicted with a chronic B-lymphoproliferative disorder, wherein said DNA segment consists of an NheI-NotI DNA fragment of the DNA sequence amplified by eFW3 (SEQ ID NO:12) and eJH (SEQ ID NO:11) and wherein said DNA segment codes for amino acids His-Thr-Ala-Val-Tyr-Tyr-Cys (SEQ ID NO:18), a peptide having a length of 7-45 amino acids, and amino acids Val-Thr-Val-Ser-Ser (SEQ ID NO:19).