Patent ID: 9029627
Filing Date: 2015-05-12
Classification: A01K,A61D,A61P,C12N

Abstract:
1. A mouse pregnant with a mouse fetus, the placenta of said fetus comprises a lentiviral vector comprised of a human soluble fms-like tyrosine kinase 1 (sFLT1)-encoding nucleic acid sequence operatively inserted in said lentiviral vector in a manner such that the human sFLT1 protein is specifically expressed in said placenta, wherein said pregnant mouse exhibits symptom of a disease selected from the group consisting of pregnancy-induced hypertension syndrome, placental insufficiency, intrauterine growth retardation, glomerulosclerosis, and proteinuria; and wherein the human sFLT1 protein is expressed in said mouse placenta throughout a gestational period of said mouse fetus.