Patent ID: 8338454
Filing Date: 2012-12-25
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A pharmaceutical composition for treating hyperproliferative diseases, inflammatory diseases, viral infections or bacterial infections in mammals comprising an antihyperproliferative disease, anti-inflammatory, antiviral or antibacterial effective amount of a compound of formula I wherein, Z is selected from sulphur, copper, silver, gold and platinum, or Z is a halogen-containing moiety selected from ClO wherein n is zero or an integer from 1 to 8 and m is zero or an integer from 1 to 8; R R wherein the broken line represents an optional double bond, with the proviso that when there is such a double bond, R or R W is absent or W is selected from (a) a 1,2-, 1,3-, or 1,4-disubstituted six membered ring which may be saturated or unsaturated with one, two or three double bonds; a 1,2-, or 1,3-disubstituted five membered ring which may be saturated or unsaturated with one or two double bonds; a 1,2-, or 1,3-disubstituted four membered ring which may be saturated or unsaturated with one or two double bonds; or a 1,2-disubstituted three membered ring which may be saturated and unsaturated with a double bond as shown by the following formulas, wherein the substituents on said disubstituted rings are the groups attached to W in formula I (b) a 1,2-, 1,3-, or 1,4-disubstituted six membered ring which may be saturated or unsaturated with one, two or three double bonds; a 1,2-, or 1,3-disubstituted five membered ring which may be saturated or unsaturated with one or two double bonds; a 1,2-, or 1,3-disubstituted four membered ring which may be saturated or unsaturated with one or two double bonds; or a 1,2-disubstituted three membered ring which may be saturated and unsaturated with a double bond as shown by the following formulas, wherein the substituents on said disubstituted rings are the groups attached to W in formula I, and said disubstituted rings may have additional substituents R (c) a ring selected from 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, or 1,7-disubstituted saturated and unsaturated 9-membered rings with one or more double bonds, with ring positions numbered as shown in the first ring set forth below, said ring selected from the second to the thirteenth rings set forth below, wherein the substituents on said disubstituted rings are the groups attached to W in formula I, and said disubstituted rings may have additional substituents R (d) a ring selected from 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, or 1,8-disubstituted saturated and unsaturated naphthalene rings with one or more double bonds, with ring positions numbered as shown in the first ring set forth below, said rings selected from the second to sixth rings set forth below, wherein the substituents on said disubstituted rings are the groups attached to W in formula I, and said disubstituted rings may have additional substituents R (e) a ring selected from 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 1,9-, 1,10-, 2,5-, 3,5-, 4,5-, or 5,10-disubstituted saturated and unsaturated anthracene rings with one or more double bonds, with ring positions numbered as shown in the first ring set forth below, said ring selected from the second to ninth rings set forth below, wherein the substituents on said disubstituted rings are the groups attached to W in formula I, and said disubstituted rings may have additional substituents R or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.