Patent ID: 6660830
Filing Date: 2003-12-09
Classification: A61K,A61P,C07K

Abstract:
An antiproliferative peptide AB or BA consisting of:an antiproliferative component (A) that is a fragment of a tumor suppressor protein or a peptide sequence hydropathically homologous thereto having the property of binding to a growth factor segment or to a growth factor receptor segment, and a component (B) that protects component (A) from the proteolytic degradation by proteases, and that is a nuclear localization sequence (NLS) selected from the group consisting of a) the amino acid sequence PKKKRKV (SEQ. ID. No. 21), b) the amino acid sequence RQIKIWFQNRRMKWKK (SEQ. ID. No. 22), c) a bipartite nuclear localization sequence (â€œNLSâ€ ), and d) the RNP A1 NLS; wherein the antiproliferative peptide is cytotoxic to tumor cells.