Patent ID: 7202251
Filing Date: 2007-04-10
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: B is a bicycloheterocycle selected from the group consisting of: where T, U, V, W, X and Y are each independently a carbon atom or a nitrogen atom wherein no more than two of T, U, V and W, and no more than three of T, U, V, W, X and Y, are a nitrogen atom, where B is unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from R R (1) —C (2) —C (3) phenyl or heterocycle, wherein heterocycle is selected from: pyridyl, pyrimidinyl, pyrazinyl, thienyl, pyridazinyl, pyrrolidinyl, azetidinyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, triazolyl, tetrazolyl, azepinyl, benzimidazolyl, benzopyranyl, benzofuryl, benzothiazolyl, benzoxazolyl, chromanyl, furyl, imidazolinyl, indolinyl, indolyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, isoindolinyl, tetrahydroisoquinolinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, pyrazolidinyl, pyrazolyl, pyrrolyl, quinazolinyl, tetrahydrofuryl, thiazolinyl, purinyl, naphthyridinyl, quinoxalinyl, 1,3-dioxolanyl, oxadiazolyl, piperidinyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, and morpholinyl, which is unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from: (4) halo, (5) oxo, (6) hydroxy, (7) —O—C (8) —CN, (9) —CO (10) —NR (11) —SO (12) —CONR (13) —OCO (14) —(NR (15) —O(CO)NR (16) —(NR (17) —(CO)—(CO)NR (18) —(CO)—(CO)OR or where R A 1 and A 2 are independently selected from: (1) a bond, (2) —CR R 4 is selected from: (1) hydrogen, (2) C (3) C (4) benzyl, and (5) phenyl; R 5a , R 5b and R 5c are independently selected from: (1) hydrogen, (2) C (3) —O—C (4) —OCF (5) trifluoromethyl, (6) halo, (7) hydroxy, and (8) —CN; R 6 is selected from: (1) hydrogen, (2) —C (3) phenyl or heterocycle, wherein heterocycle is selected from: pyridyl, pyrimidinyl, pyrazinyl, thienyl, or morpholinyl, which is unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from: m is 1 or 2; n is 1 or 2; and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof.