Patent ID: 6159142
Filing Date: 2000-12-12
Classification: A61F,A61K,A61L,A61N

Abstract:
A method of providing a stent with the capability of localized action in placement at a treatment site of an earlier angioplasty procedure for opening the lumen of a blood vessel of a patient, wherein said action is to prevent both thrombus formation on the stent when deployed in the blood vessel and restenosis of the blood vessel attributable to the angioplasty procedure, said method comprising the steps of:applying as a first layer atop an exposed surface of the stent a coating of a biodegradable carrier which is sufficiently elastic to preclude material disruption of the coating during deployment of the stent, and which undergoes disintegration at a predetermined rate in the presence of blood, having a radioactive substance of relatively low radioactivity level incorporated in said biodegradable carrier to inhibit restenosis, wherein said radioactive substance is selected to have a half life of radioactivity which is not greater than the time interval in which said biodegradable carrier undergoes disintegration, whereby to substantially avoid systemic effect of the radioactive substance on the patient, andapplying as a second layer atop said first layer a coating of a biodegradable carrier having an anti-coagulant substance incorporated therein, wherein said anti-coagulant substance is selected to inhibit thrombus formation.