Patent ID: 7731946
Filing Date: 2010-06-08
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for inhibiting interferon gamma (IFNγ) levels in a T cell or T cell population, comprising: contacting said T cell or T cell population with an interleukin-21 (IL-21) agonist in an amount sufficient to inhibit IFNγ in said T cell or T cell population, wherein the agonist is an IL-21 polypeptide comprising an amino acid sequence at least 90% identical to SEQ ID NO: 2 and which is capable of binding to an interleukin-21 receptor (IL-21R) and wherein IFNγ levels in said T cell or said T cell population are measured following contact with said agonist.