Patent ID: 6333330
Filing Date: 2001-12-25
Classification: C07D

Abstract:
A compound of formula IA, or of formula IB: ##STR73##whereinA represents CH or N;R.sup.1 represents H, lower alkyl, Het, alkylHet, aryl or alkylaryl, which latter five groups are all optionally substituted (and/or, in the case of lower alkyl, optionally terminated) by one or more substituents selected from halo, cyano, nitro, lower alkyl, OR.sup.5, C(O)R.sup.6, C(O)OR.sup.7, C(O)NR.sup.8 R.sup.9, NR.sup.10a R.sup.10b and SO.sub.2 NR.sup.11a R.sup.11b ;R.sup.2 represents C(O)NR.sup.12 R.sup.13, C(O)OR.sup.12, NR.sup.12 R.sup.13, N(H)SO.sub.2 R.sup.12, N(H)SO.sub.2 NR.sup.12 R.sup.13,N(H)C(O)R.sup.12, OR.sup.12a, lower alkyl (which alkyl group is interrupted by one or more of O, S or N(R.sup.12) and/or substituted or terminated by C(O)NR.sup.12 R.sup.13, C(O)OR.sup.12 or aryl or Het.sup.1), cyano, aryl or Het.sup.1, provided that, in a compound of formula IA wherein R.sup.2 is alkoxy, A must be N;R.sup.3, R.sup.12 and R.sup.13 independently represent H or lower alkyl, which alkyl group is optionally substituted and/or optionally terminated by one or more substituents selected from aryl,Het, halo, cyano, nitro, OR.sup.5, C(O)R.sup.6, C(O)OR.sup.7, C(O)NR.sup.8 R.sup.9, NR.sup.10a R.sup.10b andSO.sub.2 N.sup.11a R.sup.11b ;R.sup.4 represents SO.sub.2 NR.sup.14 R.sup.15 ;R.sup.14 and R.sup.15, together with the nitrogen to which they are attached, form Het;Het represents an optionally substituted four- to twelve-membered heterocyclic group, which group contains at least one nitrogen atom and, optionally, one or more further heteroatoms selected from nitrogen, oxygen and sulphur;Het.sup.1 represents an optionally substituted four- to twelve-membered heterocyclic group, which group contains at least one nitrogen atom or at least one oxygen atom and, optionally, one or more further heteroatoms selected from nitrogen, oxygen and sulphur; andR.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.11a, R.sup.11b and R.sup.12a independently represent, at each occurrence when used herein, H or lower alkyl;R.sup.10a and R.sup.10b, at each occurrence when used herein, either independently represent, H or lower alkyl or, together with the nitrogen atom to which they are attached, represent azetidinyl, pyrollidinyl or piperidinyl;or a pharmaceutically, or a veterinarily, acceptable derivative thereof.