Patent ID: 9029576
Filing Date: 2015-05-12
Classification: C07D

Abstract:
1. A process for preparing 5-sec-butyl-2-(2,4-dimethyl-cyclohex-3-enyl)-5-methyl-[1,3]dioxane consisting essentially of the steps of: (i) reacting 3-methyl-pent-3-en-2-one and hydrogen to provide 3-methyl-pentan-2-one; (ii) reacting 3-methyl-pentan-2-one of step (i) and methyl monochloroacetate to provide 3-sec-butyl-3-methyl-oxirane-2-carboxylic acid methyl ester; (iii) saponifying followed by acidifying and then decarboxylating 3-sec-butyl-3-methyl-oxirane-2-carboxylic acid methyl ester of step (ii) to provide 2,3-dimethyl-pentanal; (iv) reacting 2,3-dimethyl-pentanal of step (iii) and sodium hydroxide to provide 2-sec-butyl-2-methyl-propane-1,3-diol; and (v) reacting 2-sec-butyl-2-methyl-propane-1,3-diol of step (iv) and 2,4-dimethyl-cyclohex-3-enecarbaldehyde to provide 5-sec-butyl-2-(2,4-dimethyl-cyclohex-3-enyl)-5-methyl-[1,3]dioxane.