Patent ID: 6183774
Filing Date: 2001-02-06
Classification: A61K

Abstract:
A liposome composition comprising alkylammonium fatty acid salts and a vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof, wherein said liposome composition is substantive to epithelial cells and skin, said liposome formed by a process comprising the steps of:(a) dispersing long chain acyl N.sub.n,N.sub.n -dimethyl-1,n-diamino alkyl (A-ADDA) molecules and said vitamin A derivative in a buffering solution to form a dispersion, said buffering solution having a pH within a range of between about 3.0 to around 10.0 and an ionic strength less than or equivalent to 1 molar NaCl; and(b) subjecting the dispersion to high shear processing.