Patent ID: 7485744
Filing Date: 2009-02-03
Classification: B01J,C07B,C07C

Abstract:
1. A method for performing an iron-catalyzed allylic alkylation comprising (a) preparation of a salt-free reaction mixture obtainable from (i) an allylic substrate with a structural element C═C—C—X, wherein X comprises a leaving group that represents a carbonate, (ii) an active Fe(-II) catalyst complex, (iii) at least one ligand, (iv) at least one solvent, and (v) a nucleophile or pronucleophile; and (b) carrying out an iron-catalyzed allylic alkylation in the absence of carbon monoxide (CO) using the reaction mixture to selectively form carbon-carbon bonds on the allylic substrate with the nucleophile or pronucleophile.