Patent ID: 7884264
Filing Date: 2011-02-08
Classification: A61P,C07K,C12N

Abstract:
1. A duckweed plant or duckweed plant cell or nodule that expresses glycoproteins having an altered N-glycosylation pattern, wherein said altered N-glycosylation pattern is characterized by a reduction in the attachment of α1,3-fucose residues, β1,2-xylose residues, or both α1,3-fucose residues and β1,2-xylose residues to N-glycans of said glycoproteins when compared to the N-glycosylation pattern for said glycoproteins when expressed in a control duckweed plant or duckweed plant cell or nodule, wherein said reduction in said duckweed plant or duckweed plant cell or nodule results from inhibiting expression in said duckweed plant or duckweed plant cell or nodule of at least one α1,3-fucosyltransferase (FucT) comprising an amino acid sequence having at least 90% sequence identity to the sequence set forth in SEQ ID NO:3 and, at least one β1,2-xylosyltransferase (XylT) comprising an amino acid sequence having at least 90 % sequence identity to the sequence set forth in SEQ ID NO:6 or SEQ ID NO:21, wherein said control duckweed plant or duckweed plant cell or nodule has not been genetically modified to inhibit expression of said FucT or said XylT in said control duckweed plant or duckweed plant cell or nodule.