Patent ID: 6025374
Filing Date: 2000-02-15
Classification: A61P,C07D

Abstract:
A compound of formula I, or a salt or prodrug thereof: ##STR21## wherein Z represents hydrogen, halogen, cyano, nitro, trifluoromethyl, --OR.sup.5, --OCOR.sup.5, --OCONR.sup.5 R.sup.6, --OCH.sub.2 CN, --OCH.sub.2 CONR.sup.5 R.sup.6, --SR.sup.5, --SOR.sup.5, --SO.sub.2 R.sup.5, --SO.sub.2 NR.sup.5 R.sup.6, --NR.sup.5 R.sup.6, --NR.sup.5 COR.sup.6, --NR.sup.5 CO.sub.2 R.sup.6, --NR.sup.5 SO.sub.2 R.sup.6, --COR.sup.5, --CO.sub.2 R.sup.5, --CONR.sup.5 R.sup.6, or a group of formula (a), (b), (c) or (d): ##STR22## in which the asterisk * denotes a chiral centre; X represents oxygen, sulphur, --NH-- or methylene;Y represents oxygen or sulphur;E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;Q represents a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally substituted in any position by a hydroxy group;U represents nitrogen or C--R.sup.2 ;V represents oxygen, sulphur or N--R.sup.3 ;R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or C.sub.1-6 alkyl;R.sup.5 and R.sup.6 independently represent hydrogen, C.sub.1-6 alkyl, trifluoromethyl, phenyl, methylphenyl, or an optionally substituted aryl(C.sub.1-6)alkyl or heteroaryl(C.sub.1-6)alkyl group; or R.sup.5 and R.sup.6, when linked through a nitrogen atom, together represent the residue of an optionally substituted azetidine, pyrrolidine, piperidine, morpholine or piperazine ring;M represents the residue of an azetidine, pyrrolidine or piperidine ring;R represents a group of formula --W--R.sup.1 ;W represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;R.sup.1 represents --OR.sup.x, --SR.sup.x or --NR.sup.x R.sup.y ;R.sup.x and R.sup.y independently represent hydrogen, hydrocarbon or a heterocyclic group, or R.sup.x and R.sup.y together represent a C.sub.2-6 alkylene group; andR.sup.a represents hydrogen, hydroxy, hydrocarbon or a heterocyclic group.