Patent ID: 6265446
Filing Date: 2001-07-24
Classification: A61P,C07C,C07D,Y10S

Abstract:
A hydrazine derivative, being a compound of the formula ##STR7##whereinR.sup.1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl;R.sup.2 is heterocyclyl or NR.sup.5 R.sup.6 ;R.sup.3 is hydrogen, lower alkyl, halo-lower alkyl, cyano-lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, lower alkoxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, heterocyclyl-lower alkyl, heterocyclylcarbonyl-lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, heteroaryl or aryl-lower alkyl;R.sup.4 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, -Z-aryl, -Z-heterocyclyl or --(CH.sub.2).sub.n --CH=CR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 are each independently hydrogen or lower alkyl;R.sup.7 and R.sup.8 are each independently hydrogen or lower alkyl, or R.sup.7 and R.sup.8 together are lower alkylene or lower alkylene in which one CH.sub.2 group is replaced by S, O, or N(R.sup.11) wherein R.sup.11 is hydrogen or lower alkyl;X is --(CH.sub.2).sub.1-5 -- or --(CH.sub.2).sub.l --Y--(CH.sub.2).sub.m -- in which l and m are each independently 0, 1 or 2 and Y is arylene, lower cycloalkylene or heterocyclylene;Z is --(CH.sub.2).sub.p --W--(CH.sub.2).sub.q -- in which p and q are each independently 0, 1, 2 or 3 and W is absent or is --CH.dbd.CH--, --C.ident.C--, --S--, --O--, --NH--, --NHCO--, --CONH--, --SO.sub.2 --, --NHSO.sub.2 --, --SO.sub.2 NH--, --NHCONH-- or --NHSO.sub.2 NH--;n is 0, 1 or 2;wherein each heterocyclyl or heteroaryl is independently unsubstituted or substituted by halogen, lower alkyl, lower alkoxy, or oxo;or a mixture containing said compound and one or more optical isomers thereof, or a pharmaceutically acceptable salt of said compound or said mixture.