Patent ID: 8404459
Filing Date: 2013-03-26
Classification: A61P,C07K,G01N

Abstract:
1. A method of measuring the amount of Aβ protofibrils in a biological fluid or tissue in a subject or taken from a subject, comprising the steps of providing a monoclonal antibody or fragment thereof that binds wildtype Aβ 42/40 protofibril and Aβ42/40 Arc protofibril and has no or little cross-reactivity to Aβ 42/40 monomers, which is labeled with an agent that generates a measurable signal, contacting said labeled antibody or fragment thereof with the fluid or tissue having or suspected of comprising Aβ protofibrils, measuring the signal generated by the agent, thereby measuring the amount of Aβ protofibrils in the fluid or the tissue.