Patent ID: 6444701
Filing Date: 2002-09-03
Classification: A61P,C07C,C07D,C07F

Abstract:
A compound of formula (I) wherein: X+ is P+(R1,R2,R3), wherein R1,R2,R3, being the same or different, are selected in the group consisting of hydrogen, a C1-C9 straight or branched alkyl group, â€”CH&boxH;NH(NH2), â€”NH2, and â€”OH; or one or more R1, R2 and R3, together with the phosphorus atom which they are linked to, form a saturated or unsaturated, monocyclic or bicyclic heterocyclic system; with the proviso that at least one of the R1, R2 and R3 is different from hydrogen; Z is selected from â€”OR4, â€”OCOOR4, â€”OCONHR4, â€”OCSNHR4, â€”OCSOR4, â€”NHR4, â€”NHCOR4, â€”NHCSR4, â€”NHCOOR4, â€”NHCSOR4, â€”NHCONHR4, â€”NHCSNHR4, â€”NHSOR4, â€”NHSONHR4, â€”NHSO2R4, â€”NHSO2NHR4, and â€”SR4, wherein â€”R4 is a C1-C20 saturated or unsaturated, straight or branched alkyl group, optionally substituted with an A1 group, wherein A1 is selected from the group consisting of a halogen atom, or an aryl, heteroaryl, aryloxy or heteroaryloxy group, said aryl, heteroaryl, aryloxy or heteroaryloxy groups being optionally substituted with one or more C1-C20 saturated or unsaturated, straight or branched alkyl or alkoxy group and/or halogen atom; Yâˆ’ is selected from the group consisting of â€”COOâˆ’, PO3Hâˆ’, â€”OPO3Hâˆ’, tetrazolate-5-yl; with the proviso that when Z is â€”NHCOR4, Y is â€”COOâˆ’, then R4 is C20 alkyl; and with the proviso that when Z is â€”NHSO2R4, Yâˆ’ is â€”COOâˆ’, then R4 is not tolyl; their (R,S) racemic mixtures, their single R or S enantiomers, or their pharmaceutically acceptable salts.