Patent ID: 8513401
Filing Date: 2013-08-20
Classification: A61P,C12N

Abstract:
1. An isolated double stranded nucleic acid comprising first and second oligonucleotide strands, each strand comprising ribonucleotides and having a 5′ terminus and a 3′ terminus, wherein the first strand has a length which is 19-30 nucleotides and the second strand has a length which is 19-30 nucleotides, wherein the double-stranded nucleic acid comprises a duplex region of 19-30 nucleotides in length, wherein the second oligonucleotide strand comprises a sequence that hybridizes to a low copy promoter-specific RNA of a target gene, and wherein the isolated double stranded nucleic acid reduces target gene expression when introduced into a mammalian cell by inducing methylation of histones associated with the target gene.