Patent ID: 6511816
Filing Date: 2003-01-28
Classification: C07K

Abstract:
A method for identifying a medical compound that modulates the activity of a DNA gyrase-inhibiting protein, comprising:(a) contacting said DNA gyrase inhibiting protein to said medical compound; and (b) measuring the DNA gyrase-inhibiting activity of said protein in the presence and absence of said medical compound, wherein if in the presence of said medical compound, reduction or enhancement of DNA gyrase-inhibition occurs, but in the absence of said medical compound, reduction or enhancement of DNA gyrase-inhibition does not occur, then said medical compound modulates the activity of said DNA gyrase-inhibiting protein; and (c) selecting or identifying a medical compound that modulates the activity of a DNA gyrase-inhibiting protein; and wherein said DNA gyrase-inhibiting protein is a protein encoded by a DNA, the complement thereof which hybridizes with a DNA fragment comprising the base sequence represented by SEQ ID NO:6 or SEQ ID NO:8 under stringent conditions.