Patent ID: 6562962
Filing Date: 2003-05-13
Classification: A61P,C07C,C07D,C07F,Y02P

Abstract:
A &bgr;-lactam having the formula whereinR1 is â€”OR6, â€”SR7 or â€”NR8R9; R2 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaromatic; R3 is hydrogen, alkyl, alkenyl, alkynyl, naphthyl, substituted phenyl, or heteroaromatic; R4 is hydrogen, alkyl, alkenyl, alkynyl, naphthyl, substituted phenyl, or heteroaromatic; R5 is â€”COR10, â€”COOR10, â€”COSR10, â€”CONR8R10, â€”SO2R11, or â€”POR12R13; R6 is alkyl, alkenyl, alkynyl, aryl, heteroaromatic, or a hydroxy protecting group; R7 is alkyl, alkenyl, alkynyl, aryl, heteroaromatic, or sulfhydryl protecting group; R8 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaromatic; R9 is an amino protecting group; R10 is alkyl, alkenyl, alkynyl, phenyl, substituted phenyl, or heteroaromatic; R11 is alkyl, alkenyl, alkynyl, aryl, heteroaromatic, â€”OR10, or â€”NR8R14; R12 and R13 are independently alkyl, alkenyl, alkynyl, aryl, heteroaromatic, â€”OR10, or â€”NR8R14; and R14 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaromatic.