Patent ID: 6071276
Filing Date: 2000-06-06
Classification: A61B

Abstract:
A system for applying treatment fluid within a patient at a desired temperature comprising:a catheter having a fluid channel and fluid port therein;a fluid source operably connected to the fluid channel;a heater for fluid passing within the fluid channel, the heater being operably connected to the fluid channel to control the heat of fluid in at least part of the fluid channel;a temperature sensor on said catheter positioned to sense fluid temperature adjacent said fluid port; anda closed feedback control loop connecting said temperature sensor to said heater and operable to automatically stabilize the temperature of fluid passing out said fluid port, the closed feedback control loop including a means to compare a sensed temperature with a desired temperature and generate a signal controlling power output from the heater, and wherein said temperature sensor is on a portion of said catheter, which catheter portion is inserted in a patient during use; and wherein the heater is operable to heat cells of the patient in vivo and further comprising:a source of treatment agent including a DNA plasmid operatively connected to the fluid channel so as to apply treatment agent to the heated cells by way of the fluid channel; andwherein the treatment agent is operable to transfect the heated cells.