Patent ID: 9067996
Filing Date: 2015-06-30
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal antibody or antigen binding fragment thereof, wherein said antibody of antigen binding fragment thereof binds an epitope of a human Receptor Advanced Glycation END products (RAGE) molecule, said antibody or antigen binding fragment thereof comprising an antigen binding domain comprising: a) a heavy chain variable domain comprising complementary determining regions (CDR) 1, 2 and three wherein CDR 1, CDR 2, CDR 3 comprise the sequences of SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12, respectively; and b) a light chain variable domain comprising complementary determining regions (CDR) 1, 2, and 3 wherein the CDR 1, CDR 2, CDR 3 comprise the sequences of SEQ ID NO: 14, SEQ ID NO: 15, and SEQ ID NO: 16, respectively.