Patent ID: 6225327
Filing Date: 2001-05-01
Classification: A61K,Y10S

Abstract:
A method of alleviating ocular allergic reactions involving conjunctival mast cell degranulation which comprises topically administering a composition comprising a pharmaceutically effective amount of a human conjunctival mast cell stabilizer having a structure according to formula (I) in a pharmaceutically acceptable ophthalmic vehicle: ##STR6##wherein:A is ##STR7##n is 1 or 2;when n is 1,X is H, halogen, CF.sub.3, alkyne, --S(O).sub.n' R, OR or NO.sub.2 ;when n is 2,X is H or halogen;n' is 0, 1 or2;R is C.sub.1 -C.sub.5 (un)branched alkyl;Y is Z(C(R')(R')).sub.n"" Z' or ##STR8##wherein:n"" is 2 to 4;m is 0, 1, 2, 3;R' is H or R;X' is H, halogen, CF.sub.3, alkyne, --S(O).sub.n' R, OR or NO.sub.2 ;Z is NH or O;Z' is N(R')(R"") or ##STR9##R"" is ##STR10##provided that the human conjunctival mast cell stabilizer is not nicardipine.