Patent ID: 8927486
Filing Date: 2015-01-06
Classification: A61K,A61P,C07K

Abstract:
1. A compound, or pharmaceutically acceptable salt thereof, comprising a vascular disrupting agent (VDA) associated with a matrix metalloproteinase (MMP) proteolytic cleavage site, wherein the VDA is selected from the group consisting of azademethylcolchicine, colchicine, azacolchicine, N-methyl desacetylcolchicine, desacetylcolchicine, N-acetylcolchinol-O-phosphate, colchicinoids, combrestatins, phenstatin, podophyllotoxins, steganacins, amphethinile, stilbenes, flavonoids, vincristine, vinblastine, vinflunine, maytansinoids, phomopson A, rhizoxin, auristatin, and dolstatin, and the MMP proteolytic cleavage site comprises the amino acid sequence eu-P2′-Hof-Gly-Cit-Ser-Arg, wherein P2′ is an amino acid selected from Asp, Ala, Ser, Asn, Pro, Leu, Arg and Thr.