Patent ID: 6194598
Filing Date: 2001-02-27
Classification: A61P,C07H,Y02P

Abstract:
A compound of the structure:Q--Lwherein:L has one of the structures: ##STR6##wherein:m is from 1 to 10;y is from 1 to 10;E is N(R.sub.1)(R.sub.2) or N.dbd.C(R.sub.1)(R.sub.2);each R.sub.1 and R.sub.2 is, independently, H, C.sub.1 -C.sub.10 alkyl, a nitrogen protecting group, or R.sub.1 and R.sub.2, together, are a nitrogen protecting group or wherein R.sub.1 and R.sub.2 are joined in a ring structure that can include at least one heteroatom selected from N and O;and x and Q are selected such that:when x is 0, then Q is of the structure: ##STR7##wherein:each n and p is, independently, from 0 to 10 with the sum of n and p being greater than 2 and less then 11;Pg is a hydroxyl protecting group; andZ is a solid support or a protected phosphoramidite, H phosphonate, or phosphate triester.