Patent ID: 8198025
Filing Date: 2012-06-12
Classification: C12Q,G01N

Abstract:
1. A method for detecting, identifying, or predicting the presence of esophageal cancer comprising determining in vitro an expression level of at least an esophageal cancer-associated target nucleic acid consisting of the nucleotide sequence of SEQ ID NO: 143 or a sequence having at least 95% sequence identity with SEQ ID NO: 143, in a biological sample obtained from the esophagus of a human subject using a composition, kit or chip comprising: (a) a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 143, a nucleotide sequence having at least 95% sequence identity with SEQ ID NO: 143, or a fragment of SEQ ID NO: 143 comprising at least 15 contiguous nucleotides of SEQ ID NO: 143; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 143; (c) a polynucleotide consisting of a nucleotide sequence that is a full-length complement of the nucleotide sequence of SEQ ID NO: 143, a nucleotide sequence having at least 95% sequence identity with the full-length complement of SEQ ID NO: 143, or a fragment thereof comprising at least 15 contiguous nucleotides of the full-length complement of SEQ ID NO: 143; or (d) a polynucleotide comprising a nucleotide sequence that is a full-length complement of the nucleotide sequence of SEQ ID NO: 143, wherein the determination of the expression level is compared to the expression level value obtained from a control sample and a decrease in the expression level of SEQ ID NO: 143 or the sequence having at least 95% sequence identity with SEQ ID NO: 143 in the biological sample detects, identifies or predicts the presence of esophageal cancer.