Patent ID: 8685450
Filing Date: 2014-04-01
Classification: A61K,A61P

Abstract:
1. A dosage form for delivering a first drug that is immediately released upon ingestion and a second drug that is released by prolonged release, comprising a prolonged-release portion comprising the second drug dispersed in a solid matrix comprising a first polymer, wherein the matrix (i) swells upon imbibition of fluid to a size that promotes retention of the dosage form in a stomach and (ii) releases substantially all of the second drug within about 10 hours upon immersion of the dosage form in fluid; a polymeric film adhering to a surface of the prolonged-release portion, wherein the polymeric film is devoid of the first drug and the second drug and wherein the film comprises a second polymer having a molecular weight which is lower than the molecular weight of the first polymer and is dissolved in gastrointestinal fluid upon ingestion; and an immediate-release portion comprising a solid layer adhering to the polymeric film, the solid layer comprising the first drug for immediate release upon immersion of the dosage form in fluid; wherein the weight ratio of polymer in the polymeric film to polymer in the solid matrix is from 0.005:1 to 0.2:1.