Patent ID: 7691879
Filing Date: 2010-04-06
Classification: A61P,C07D

Abstract:
1. A compound of formula I or a pharmaceutically acceptable salt, wherein: A is Y is CH G is H R said alkyl, aryl, and cycloalkyl being unsubstituted, monosubstituted with R R R R R said alkyl, aryl, and cycloalkyl is unsubstituted, mono-substituted with R R said alkyl, aryl, and cycloalkyl is unsubstituted, mono-substituted with R R said alkyl, aryl, and cycloalkyl is unsubstituted, mono-substituted with R R R n, r, s and t are independently 0, 1, 2, 3, 4, 5 or 6; u is 0, 1 or 2; and v is 0, 1 or 2, wherein said compound is selected from the group consisting of [(6-methoxy-4-phenylisoquinolin-3-yl)methyl]dimethylamine, 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine, {[6-methoxy-1-(methylthio)-4-phenylisoquinolin-3-yl]methyl}dimethylamine, [6-methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]methyl(dimethyl)amine oxide, 1-[6-methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]-N,N-dimethylmethanamine, 3-[(dimethylamino)methyl]-6-methoxy-4-phenylisoquinoline-1-carbonitrile, 2,3-Dimethyl-6-methoxy-4-phenylisoquinolinium hydroxide, 6-methoxy-1-(2-methoxyethoxy)-3-methyl-4-phenylisoquinoline, {3-[(6-methoxy-3-methyl-4-phenylisoquinolin-1-yl)oxy]propyl}amine, 2-[(6-methoxy-3-methyl-4-phenylisoquinolin-1-yl)amino]ethanol, 6-methoxy-3-methyl-1-(methylsulfonyl)-4-phenylisoquinoline, 6-methoxy-N-(2-methoxyethyl)-3-methyl-4-phenylisoquinolin-1-amine, N-(6-methoxy-3-methyl-4-phenylisoquinolin-1-yl)ethane-1,2-diamine, 6-methoxy-3-methyl-4-phenylisoquinoline, N-(3,4-dimethoxybenzyl)-6-methoxy-3-methyl-4-phenylisoquinolin-1-amine, 6-methoxy-3-methyl-4-phenylisoquinolin-1-amine, 1-(ethylsulfonyl)-6-methoxy-3-methyl-4-phenylisoquinoline, 1-(benzylsulfonyl)-6-methoxy-3-methyl-4-phenylisoquinoline, 6-methoxy-3-methyl-4-phenyl-1-(phenylsulfonyl)isoquinoline, 6-methoxy-3-methyl-4-phenylisoquinoline-1-carbonitrile, 3-tert-butyl-6-methoxy-1-(2-methoxyethoxy)-4-phenylisoquinoline, 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 6-methoxy-4-phenylisoquinoline-1,3-dicarbonitrile, 1-(allyloxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-(2,3-dihydroxypropoxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (+/−)-1-[(2,3-dihydroxypropyl)amino]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(2S)-2,3-dihydroxypropyl]amino}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(2R)-2,3-dihydroxypropyl]amino}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (+/−)-1-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(2R)-2,3-dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-{[(2S)-2,3-dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (+/−)-1-{[2,3-dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-[(3R)-3-hydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-[(3S)-3-hydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (+/−)-1-[3-hydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-[cis-3,4-dihydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 6-methoxy-4-phenyl-1-pyrrolidin-1-ylisoquinoline-3-carbonitrile, 6-methoxy-1-(methylsulfonyl)-4-phenylisoquinoline-3-carbonitrile, 6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1,6-dimethoxy-4-phenylisoquinoline-3-carbonitrile, 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-6-methoxy-1-methylisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-1-[(2-hydroxyethyl)amino]-6-methoxyisoquinoline-3-carbonitrile, 1-amino-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-1-[(3-hydroxypropyl)amino]-6-methoxyisoquinoline-3-carbonitrile, 1-(but-3-enyloxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-(2,3-dihydroxypropoxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(2R)-2,3-dihydroxypropoxy]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(2S)-2,3-dihydroxypropoxy]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-(3,4-dihydroxybutoxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-[(3R)-3,4-dihydroxybutoxy]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(3S)-3,4-dihydroxybutoxy]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-[(1,4-dioxan-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(1,4-dioxan-(2R)-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(1,4-dioxan-(2S)-2-ylmethyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-6-methoxy-1-[(1-methyl-1H-imidazol-4-yl)methoxy]isoquinoline-3-carbonitrile, (+/−)-1-(1,3-dioxolan-4-ylmethoxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-(1,3-dioxolan-(4R)-4-ylmethoxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-(1,3-dioxolan-(4S)-4-ylmethoxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-(1,3-dioxan-5-yloxy)-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-1-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}-6-methoxyisoquinoline-3-carbonitrile, 4-(3-fluorophenyl)-1-(1H-imidazol-5-ylmethoxy)-6-methoxyisoquinoline-3-carbonitrile, 1-{[(2R)-2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-{[(2S)-2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-{[2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-(1H-imidazol-1-yl)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 6-methoxy-4-phenyl-1-[(pyridin-2-ylmethyl)amino]isoquinoline-3-carbonitrile, 6-methoxy-4-phenyl-1-[(2-pyridin-2-ylethyl)amino]isoquinoline-3-carbonitrile, (+/−)-1-[(3,4-dihydroxybutyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(3R)-(3,4-dihydroxybutyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(3S)-(3,4-dihydroxybutyl)amino]-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-chloro-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-1-[(2,3-dihydroxypropyl)amino]-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(2S)-(2,3-dihydroxypropyl)amino]-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, 1-[(2R)-(2,3-dihydroxypropyl)amino]-4-(2-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile, (+/−)-6-(difluoromethoxy)-1-{[2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, 6-(difluoromethoxy)-1-{[(2S)-2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, 6-(difluoromethoxy)-1-{[(2R)-2,3-dihydroxypropyl]amino}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, (+/−)-6-(difluoromethoxy)-1-{[2,3-dihydroxypropyl]oxy}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, 6-(difluoromethoxy)-1-{[(2S)-2,3-dihydroxypropyl]oxy}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, 6-(difluoromethoxy)-1-{[(2R)-2,3-dihydroxypropyl]oxy}-4-(3-fluorophenyl)isoquinoline-3-carbonitrile, 1-(4-hydroxypiperidin-1-yl)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-azetidin-1-yl-6-methoxy-4-phenylisoquinoline-3-carbonitrile, (+/−)-1-[trans-3,4-dihydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, 1-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile, and 6-methoxy-N-(3-methoxypropyl)-3-methyl-4-phenylisoquinolin-1-amine.