Patent ID: 6500798
Filing Date: 2002-12-31
Classification: A61K

Abstract:
A method for modulating the oxidative stress level in a cell, the method comprising contacting the cell with an oxidative stress regulator under conditions effective to decrease the level of an oxidizing species present in the cell in response to an oxidative stress compared to the same conditions when the oxidative stress regulator is not present; wherein the oxidative stress regulator is colostrinin, a constituent peptide thereof, an active analog of a constituent peptide of colostrinin selected from the group of SEQ ID NO:1 through SEQ ID NO:34 and combinations thereof; wherein the active analog comprises a peptide having an amino acid sequence with at least about 15 percent proline and having at least about 70 percent structural similarity to one or more constituent peptides of colostrinin; and further wherein the active analog does not interfere with cellular uptake of redox-sensitive 2â€²,7â€²-dihydro-dichlorofluorescein-diacetate.