Patent ID: 9018441
Filing Date: 2015-04-28
Classification: A01K,C07K,C12N

Abstract:
1. A method of producing a transgenic, hairless, immunodeficient mouse whose genome comprises a homozygous Prkdc scid mutation and a homozygous Hr hr mutation on a non-obese diabetic NOD.CB17 background, the method comprising: (a) crossing a homozygous NOD.CB17-Prkdc (b) crossing the heterozygous progeny produced from step (a) with NOD.CB17-Prkdc (c) selecting an offspring of step (b) that has a NOD.CB17 background, is homozygous for the Prkdc allele, and is heterozygous for the Hr allele; (d) crossing the offspring selected in step (c) with mice homozygous or heterozygous for the Hr allele to obtain a homozygous NOD.CB17-Prkdc wherein the NOD.CB17-Prkdc