Patent ID: 6114371
Filing Date: 2000-09-05
Classification: C07D

Abstract:
A 3-(cyclohexanoheteroarylidene)-2-indolinone compound having the following chemical structure: ##STR5## wherein, A is selected from the group consisting of oxygen and sulfur;Z is selected from the group consisting of oxygen, sulfur and NR.sup.12 wherein,R.sup.12 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, carbonyl, C-carboxy, O-carboxy, C-amido, guanyl, sulfonyl and trihalomethanesulfonyl;R.sup.1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, C-carboxy, C-amido, trihalomethanecarbonyl, trihalomethanesulfonyl and sulfonyl;R.sup.2 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and halogen;R.sup.3, R.sup.3', R.sup.4, R.sup.4', R.sup.5, R.sup.5', R.sup.6 and R.sup.6' are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, alkoxy, aryloxy, thioalkoxy, thioaryloxy, heteroaryloxy, heteroalicycloxy, sulfinyl, sulfonyl, S-sulfonamido, N-Sulfonamido, trihalomethanesulfonyl, carbonyl, C-carboxy, O-carboxy, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, phosphonyl, N-thiocarbamyl, guanyl, guanidino, ureido, amino, trihalomethanesulfonamido, and --NR.sup.13 R.sup.14 ; whereinR.sup.13 and R.sup.14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a five- or six-member heteroalicyclic ring;when any of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are hydrogen, R.sup.3', R.sup.4', R.sup.5' and R.sup.6', respectively, in addition to being independently selected from the above group, may be independently selected from the group consisting of hydroxy and thiohydroxy;combined, R.sup.3 and R.sup.3', R.sup.4 and R.sup.4', R.sup.5 and R.sup.5', and R.sup.6 and R.sup.6' may be independently selected from the group consisting of keto, five-member spirocycloalkyl, five-member spiroheteroalicyclyl, six-member spirocycloalkyl and six member spiroheteroalicyclyl;R.sup.7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, trihaloalkyl alkenyl, alkynyl, aryl, heteroaryl, C-carboxy, O-carboxy, halo, cyano, nitro, hydroxy, alkoxy,R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, alkenyl, alkynyl, cycycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, cycloalkoxy, aryloxy, heteroaryloxy, heteroalicycloxy, thiohydroxy, thioalkyoxy, thiocycloalkoxy, thioheteraryloxy, thioheteralicycloxy, halo, nitro, cyano, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, silyl, phosphonyl, C-carboxy, O-carboxy, N-amido, C-amido, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethanesulfonyl, guanyl, guanidino, trihalomethanesulfonamido, amino and --NR.sup.13 R.sup.14, wherein,R.sup.13 and R.sup.14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a five- or six-member heteroalicyclic ring;or a physiologically acceptable salt thereof.