Patent ID: 6548534
Filing Date: 2003-04-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I in whichR1 and R2 are the same or different and each stands for a hydrogen atom, a C1-C5, alkyl, or a halogen atom, or R1 and R2 together with the C-atom of the chan form a 3-7-membered ring; R3 stands for a C1-C5 alkyl group or a partially or completely fluorinated C1-C5 alkyl group; A stands for a monocyclic or bicyclic, carbocylic or heterocyclic, aromatic ring that is optionally substituted by one or more radicals, selected from halogen atoms, C1-C5 alkyl groups, C2-C5 alkenyl groups -CR5=CR6R7, hydroxy groups, or hydroxy groups that carry a C1-C10 acyl group, a C3-C10 carbalkoxyalkyl group, a C2-C5 cyanalkyl group, a C3-C10 unsubstituted or substituted allyl group, a C3-C10 unsubstituted or substituted propargyl group, a C2-C5 alkoxyalkyl gorup, a C1-C5 alkyl group that is partially or completely substituted by fluorine atoms, a cyano group, a nitro group, C1-C5 alkoxy groups, C1-C5 alkyltho groups, mono- or disubstituted C1-C10 amino groups, or partially or completely fluorinated C1-C5 alkyl groups; A may also stand for an ester group -COOR4, a C2-C5 alkenyl group -CR5â€™=CR6â€™R7â€™, an alkynyl group -Câ‰¡CR5, or a partially or completely fluorinated C1-C5 alkyl group; R4 is a C1-C5 alkyl group: R5, R6 and R7 are the same or different and, independently of one another, are each hydrogen atoms or C1-C5 alkyl groups; R5â€™, R6â€™ and R7â€™ are the same or different, and, independently of one another, mean hydrogen atoms, halogen atoms, aryl radical or C1-C5 alkyl groups; B stands for a carbonyl group or a CH2 group; and Ar stands for a ring system, selected from the group of partial formulas 5 and 8, in whichâ€ƒradicals X3a, X3b, X4, X6, X7, Y4, Y5, Y7 and Y8 are each the same or different and are selected from hydrogen atoms C1-C5 alkyl groups, which in addition may contain a hydroxy group that is optionally etherified with a C1-C5 alkyl group or esterified with a C1-C5 alkanoyl group, partially or completely fluorinated C1-C5 alkyl groups, C2-C5 alkenyl groups -CR5=CR6R7, alkynyl groups -Câ‰¡CR5, radicals X3a and X3b also together with the C-atom of benzocondensed ring system of partial formula 5 may form a 3-7 membered ring, and radicals X4, X6, X7, Y4, Y5, Y7, Y8 in partial formulas 5 and 8 may also be selected from halogen atoms, hydroxy groups, C1-C5 alkoxy groups or C1-C5 alkanoyloxy groups; also, if B in general formula I is a CH2 group, Ar can also be a phenyl radical of partial formula 12, in whichâ€ƒR9 and R10 are the same or different and mean a cyano group, a nitro group, a halogen atom, a C1-C5 alkyl group, a partially or completely fluorinated C1-C5 alkyl group, a C1-C5 alkylthio group, a C1-C5 alkylsulfinyl group or a C1-C5 alkylsylfonyl group; or if B stands for a CH2 group, a physiologically compatible salt of a compound of formula I.