Patent ID: 6271232
Filing Date: 2001-08-07
Classification: C07D

Abstract:
A compound of formula: ##STR12##wherein R.sup.1 is selected from the group consisting of --CH.sub.2 R.sup.8 and --CHR.sup.8 R.sup.9, and R.sup.4 is selected from the group consisting of hydrogen and --CH.sub.2 R.sup.8 and --CHR.sup.8 R.sup.9 ;R.sup.2, R.sup.3, R.sup.5, R.sup.6 and R.sup.8 are independently selected from the group consisting of(i) hydrogen;(ii) an alkyl group of from 1 to 12 carbon atoms, optionally substituted;(iii) --NR'C(O)--X--R"" where R' and R"" are independently selected from the group consisting of hydrogen, alkyl of from 1 to 12 carbon atoms, substituted alkyl of from 1 to 12 carbon atoms, aryl groups of from 6 to 10 carbon atoms optionally substituted with from 1 to 3 substituents on the aryl moiety selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, amido, amino, aryloxy, carboxyl, halo, mercapto, cyano, nitro, --SO.sub.3, and --SO.sub.2 NH.sub.2, and X is selected from the group consisting of a bond, O, and NR' where R' is as defined above;(iv) --OC(O)Y--R"" where R"" is selected from the group consisting of alkyl of from 1 to 12 carbon atoms, substituted alkyl of from 1 to 12 carbon atoms, aryl groups of from 6 to 10 carbon atoms optionally substituted with from 1 to 3 substituents on the aryl moiety selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, amido, amino, aryloxy, carboxyl, halo, mercapto, cyano, nitro, --SO.sub.3, and --SO.sub.2 NH.sub.2, and Y is selected from the group consisting of a bond and NR' where R' is as defined above;(v) alkenyl groups of from 2 to 10 carbon atoms;(vi) alkynyl groups of from 3 to 10 carbon atoms;(vii) carboxyl groups;(viii) carboxyl ester groups wherein the ester group comprises from 1 to 12 carbon atoms;(ix) heterocycles, either saturated, unsaturated or aromatic, having from 2 to 6 carbon atoms and 1 to 3 ring hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur, optionally substituted;(x) R--C(O)-- groups where R is hydrogen or an alkyl group of from 1 to 12 carbon atoms, optionally substituted on the alkyl group;(xi) aryl group of from 6 to 10 carbon atoms optionally substituted with 1 to 3 substituents on the aryl moiety selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, amido, amino, aryloxy, carboxyl, halo, mercapto, cyano, nitro, --SO.sub.3, and --SO.sub.2 NH.sub.2 ; and(xii) arylalkyl, optionally substituted on the aryl group and/or the alkyl group; or whereinR.sup.2, R.sup.3 and the carbon to which they are attached form a cycloalkyl or heterocyclic group; orR.sup.1 and R.sup.2 and the carbon and nitrogen to which they are attached, respectively, form a heterocyclic group;R.sup.4 and R.sup.5 and the carbon and nitrogen to which they are attached, respectively, form a heterocyclic group;R.sup.7 is hydrogen;R.sup.9 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclic or substituted heterocyclic; andn is an integer from 1 to 3;and a pharmaceutical salt thereof.