Patent ID: 6759234
Filing Date: 2004-07-06
Classification: A61K

Abstract:
A method of treating allergy in humans comprising administering to a human at least one therapeutic composition in an amount sufficient to down regulate a protein allergen specific immune response in the human, wherein the therapeutic composition comprises at least one isolated peptide having a defined sequence of amino acid residues, said peptide comprising at least about 20% of the T cell epitopes of the protein allergen, said peptide being reproducible and not being conjugated to any other molecule, said peptide having a mean T cell stimulation index of at least about 3.5determined in an in vitro T cell proliferation assay with T cell obtained from a population of humans sensitive to said allergen, and said peptide having a positivity index of at least 150 as determined in an in vitro T cell proliferation assay with T cell obtained from a population of humans sensitive to said allergen, wherein the composition is first administered at three to six dosages of said composition once a week for three to six weeks.