Patent ID: 6383812
Filing Date: 2002-05-07
Classification: C07H

Abstract:
A method of synthesizing branched galactose-terminal glycoprotein comprising the steps of:coupling an amino alcohol with a chemically protected ester of a dicarboxylic acid, which dicarboxylic acid is selected from the group consisting of glutamic and aspartic acids to produce A; reacting A with the oxazoline of N-acetyl galactosamine to produce the amino acid derivative B; reacting a 1,3 diacetate of N-acetyl galatosamine with a monobenzyl ester of a dicarboxylic acid selected from the group consisting of succinic, glutaric, adipic, maleic and fumaric acids to produce C; reacting C with a chemically protected amino alkyl alcohol to produce D; attaching D to an amide resin; reacting the attached D with B to form E that is attached to the amide resin; reacting the attached E with an amino acid having a chemically protected amino group; deprotecting and cleaving from the resin to form the branched galactose-terminal glycoprotein.