Patent ID: 8796455
Filing Date: 2014-08-05
Classification: A61K,A61P,C07D

Abstract:
1. A compound represented by Formula (I): wherein: X X X R Q A and B are respectively, 5 membered heteroaromatic and 6 membered aromatic or heteroaromatic rings, fused together to form a 9-membered heteroaromatic system excluding 5-benzo[b]furyl and 3-indolyl; or Q R W is independently, hydrogen, —N(C Y is independently, hydrogen, —N(C G or G provided that Q R E or E in the cases of —NR m is 0, 1, 2, or 3; n is 0, 1, 2, 3, or 4; and aa is 0 or 1; and provided that the compound is not trans-4-[8-amino-1-(7-chloro-4-hydroxy-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]cyclohexanecarboxylic acid; cis-3-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanecarboxylic acid, trans-4-{8-amino-1-[7-(3-isopropyl)phenyl-1H-indol-2-yl]imidazo[1,5-a]pyrazin-3-yl}cyclohexanecarboxylic acid; or trans-4-{8-amino-1-[7-(2,5-dichloro)phenyl-1H-indol-2-yl]imidazo[1,5-a]pyrazin-3-yl}cyclohexane carboxylic acid; or a pharmaceutically acceptable salt thereof.