Patent ID: 8022190
Filing Date: 2011-09-20
Classification: A61K,A61P,C07K

Abstract:
1. A molecule comprising consecutive amino acids present in the following consecutive segments, beginning at the amino terminus of the molecule: (i) a human MHC-restricted peptide capable of eliciting a memory response when present in the molecule, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, and (vi) a tumor-specific antibody targeting domain which comprises an association of a heavy chain variable region and a light chain variable region, wherein the consecutive amino acids which correspond to segments (v) and (vi) are linked to each other directly by a peptide bond or by a third peptide linker and wherein the carboxyl terminus of each of segments (i) through (v) is covalently linked to the amino terminus of segments (ii) through (vi), respectively.