Patent ID: 6262272
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A method for preparing a compound of the formula ##STR19##wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1 -C.sub.6 alkyl; and Ar is phenyl or heterocycle; or phenyl or heterocycle substituted with up to three substituents selected from C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 perflouroalkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 perfluoroalkoxy, F, Cl, Br, --O--(CH.sub.2).sub.k --O--, or (CH.sub.2).sub.m NR.sup.1 R.sup.2 ; or Ar is 4-(N-methyl-N-t-butylcarboxy-aminomethyl)-phenylwhereinn is an integer selected from 0 to 2;m is an integer selected from 0 to 6; andk is an integer selected from 1 or 2;which comprises:1) reacting a compound of the formula ##STR20##with an excess of an acid chloride or anhydride in a reaction inert solvent containing an excess of an acid acceptor until reaction is complete;2) adding an equivalent amount of NH.sub.2 --Ar to the solution of step 1 and holding until reaction is complete.