Patent ID: 6143853
Filing Date: 2000-11-07
Classification: B01D,B01J,G01N

Abstract:
A poly(vinyl ether) which is insoluble in water or aqueous liquids comprising a chain of repeating vinyl ether subunits and having the structure ##STR11## where a) the free terminal valences bind to groups derived from the termination or initiation of the polymerization reaction used to synthesize the poly(vinyl ether);b) X.sub.1, X.sub.2, X.sub.3 . . . X.sub.m and Y.sub.1, Y.sub.2, Y.sub.3 . . . Y.sub.m are hydrogen or methyl;c) R.sub.1, R.sub.2 . . . R.sub.m' are groups selected from the group consisting ofi) hydrocarbyl groups, andii) R.sub.1 =R'.sub.1 --B.sub.1 --, R.sub.2 =R'.sub.2 --B.sub.2 -- . . . R.sub.m' =R'.sub.m' --B.sub.m' -- where R'.sub.1, R'.sub.2 . . . R'.sub.m' in turn are selected from the group consisting of OH, NH.sub.2 and substituted forms thereof, in which a hydrogen has been replaced by an organic residue R"", wherein R"" is an affinity ligand having affinity to a bioorganic molecule, a thiol function (SH) or a function that quantitatively forms a disulfide with a thiol function, and B.sub.1, B.sub.2 . . . B.sub.m' (=B) are hydrophilic organic bridges, respectively;d) m' is an integer giving the number of blocks containing identical repeating vinyl subunits; ande) n.sub.1, n.sub.2, . . . n.sub.m' are integers greater than zero and n.sub.1 +n.sub.2 + . . . +n.sub.m' =n, where n is the number of vinyl subunits in the chain, with the proviso that a plurality of the vinyl ether subunits carry R.sub.1, R.sub.2 . . . or R.sub.m' that are selected among HO--B-- or H.sub.2 N--B-- or forms thereof in which a hydroxy hydrogen or an amino hydrogen is substituted by a hydrophilic organic group;wherein said poly(vinyl ether) is insoluble in water or aqueous liquids bya) at least one of said organic residues R"" being covalently attached to a support (matrix carrier) insoluble in the aqueous liquid;b) a plurality of said organic residues R"" participating in inter- and/or intramolecular crosslinking of the poly(vinyl ether); orc) the presence of a plurality of hydrophobic R groups that are physically adsorbed to a hydrophobic support (matrix carrier).