Patent ID: 8552199
Filing Date: 2013-10-08
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula I in which R1 R2 or R1 and R2 form, together with the nitrogen atom to which they are bonded, a 4- to 10-membered mono-, bi- or spirocyclic ring which, apart from the nitrogen atom, optionally including 0 to 3 additional heteroatoms selected from the group of oxygen, nitrogen and sulfur, where the heterocyclic ring system is optionally substituted by F, Cl, Br, CF R10, R11 R9, R13, R14, R16, R17, R18, R19, R20, R21, R22, R23, R24 or R16 and R17, R23 and R24 q, r are each independently 0, 1, 2, 3, 4, 5, 6; R12, R15 R25, R26, R27, R28, R29, R30, R31, R32, R33 or R27 and R28, R29 and R30, R31 and R32 L1is C(R34)(R35), C(R36)(R37)C(R38)(R39), (C R34, R35, R36, R37, R38, R39 R3, R4, R5 R40, R41, R42 or R40 and R41 R6, R6′, R7, R7′ R8 is H, (C A is a 5-6-membered aromatic ring optionally including up to 2 heteroatoms selected from the group of nitrogen, oxygen and sulfur, and optionally substituted by one or more of the substituents H, F, Cl, Br, I, OH, CF optionally, C(O)NR8 is joined to an ortho substituent of A via a bridge comprising one or two elements from the group of carbon and nitrogen so as to form, overall, a 9- to 10-membered bicyclic ring; R43, R44, R45, R46, R47, R48, R49 are each independently H, (C or R43 and R44, R45 and R46 L2 is a bond or a linker with 1 to 4 members, where the members are selected from the group consisting of O and C(R51)(R52), to form a chemically viable radical, and the linker has no O—CO or COO groups; B is (C R50, R51, R52, R53 and the physiologically compatible salts thereof.