Patent ID: 6566087
Filing Date: 2003-05-20
Classification: A61P,C12N

Abstract:
A method to identify a specific binding partner of a PDE8 polypeptide comprising the steps of:a) contacting the PDE8 polypeptide with a compound under conditions which permit binding between the compound and the PDE8 polypeptide; b) detecting binding of the compound to the PDE8 polypeptide; and c) identifying the compound as a specific binding partner of the PDE8 polypeptide; said PDE8 polypeptide encoded by a polynucleotide selected from the group consisting of polynucleotides that hybridize under moderately stringent conditions to the complement of a polynucleotide encoding a polypeptide set out in SEQ ID NO: 2, 4, or 6, said moderately stringent conditions comprising a final wash at 65Â° C. in 2Ã—SSC and 0.1% SDS.