Patent ID: 6797842
Filing Date: 2004-09-28
Classification: C07B,C07C

Abstract:
A process for producing an optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine represented by formula 5: wherein R represents a fluorine atom or trifluoromethyl group, n represents 1 to 5, and R takes an arbitrary substitution position, except for the ortho position when R is a fluorine atom and n is 1, and the asterisk represents a chiral carbon, comprising: asymmetrically reducing an optically active imine represented by formula 3: wherein R represents a fluorine atom or trifluoromethyl group, n represents 1 to 5 and R takes an arbitary substitution position, except for the ortho position when R is a fluorine atom and n is 1, Ar represents a phenyl group or 1- or 2-naphthyl group, and the asterisk represents a chiral carbon using a hydride reducing agent, converting to an optically active secondary amine represented by formula 4: wherein R represents a fluorine atom or trifluoromethyl group, n represents 1 to 5 and R takes an arbitrary substitution position, except for the ortho position when R is a fluorine atom and n is 1, Ar represents a phenyl group or 1- or 2-naphthyl group, and the asterisks represent chiral carbons), and subjecting the secondary amine, its salt of an inorganic acid or its salt of an organic acid to hydrogenolysis.