Patent ID: 6376533
Filing Date: 2002-04-23
Classification: A61K,C07D

Abstract:
A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound represented by formula I: wherein the hatched segment represents an &agr; bond, the solid triangle represents a &bgr; bond, the wavy segment represents &agr; or &bgr; bond, dashed lines represent a double bond or a single bond, R3 is heteroaryl or a substituted heteroaryl radical, R1 and R2 are independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of CO2R4, CONR42, CH2OR4, CONR4SO2R4, P(O)(OR4) and wherein R4 is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is 0 or an integer of from 1 to 4.