Patent ID: 7695920
Filing Date: 2010-04-13
Classification: C07K

Abstract:
1. A method of screening for a substance that specifically binds with an isolated protein selected from the group consisting of: (a) an isolated protein having the amino acid sequence set forth in SEQ ID NO: 2; (b) an isolated protein which binds to Rab3A-interacting molecule (RIM1), wherein said protein (c) an isolated protein encoded by an isolated DNA that hybridizes under stringent conditions to a DNA that has a nucleotide sequence complementary to the nucleotide sequence set forth in SEQ ID NO: 1, wherein the stringent conditions are hybridization at 65° C. for two and a half hours followed by washing in 2×SSC and 0.05% SDS at 25° C. for five minutes; and (d) an isolated protein encoded by an isolated DNA having a nucleotide sequence with 95% or more homology to the nucleotide sequence set forth in SEQ ID NO: 1 and encoding a protein which binds to RIM1, and wherein said protein contains Ile-Trp-Ala at the C-terminus; said method comprising (1) contacting a test substance with said protein; and (2) detecting the presence of binding between the test substance and said protein.