Patent ID: 9125847
Filing Date: 2015-09-08
Classification: A61K,A61P,Y02A

Abstract:
1. An immunogenic conjugate having the formula: wherein, C is a CRM X P is a peptide immunogen comprising an Aβ fragment covalently attached to the derivatized functional group of the amino acid residue of the carrier protein, wherein the Aβ fragment comprises residues 16-23 of Aβ (SEQ ID NO:21), R is a capping molecule covalently attached to the derivatized functional group of an amino acid residue of the carrier protein, wherein the functionality of the carrier protein is preserved such that it retains its ability to elicit the desired immune responses against the peptide immunogen that would otherwise not occur without a carrier, n is an integer greater than 0, but less than or equal to 38, and p is an integer greater than 0, but less than 38.