Patent ID: 8486983
Filing Date: 2013-07-16
Classification: A61K

Abstract:
1. An orally bioavailable self-emulsifying or self-microemulsifying pharmaceutical formulation comprising: (1) 1-30% by weight of a compound which is a CETP inhibitor, or a pharmaceutically acceptable salt thereof; (2) a fatty acid ester oil phase, wherein said fatty acid ester oil phase comprises one or more compounds selected from the group consisting of fatty acid monoglycerides, fatty acid diglycerides, fatty acid monoesters of propylene glycol, fatty acid diesters of propylene glycol, fatty acid monoesters of sorbitan, fatty acid diesters of sorbitan, fatty acid triesters of sorbitan, and mixtures thereof, wherein said fatty acids are selected from medium chain C (3) one or more nonionic surfactants having a hydrophilic lipophilic balance (HLB) in the range of 10-20; wherein the ratio of the fatty acid ester oil phase and the one or more nonionic surfactants is 1:4 to 4:1 by weight; wherein the formulation does not include a cosolvent selected from the group consisting of triacetin, propylene carbonate, transcutol, ethyl lactate, triethyl citrate, N-methyl-2-pyrrolidinone, dimethylisosorbide, glycofurol, ethanol, and ethoxyethylene glycol; wherein the CETP inhibitor has formula II: