Patent ID: 6168791
Filing Date: 2001-01-02
Classification: A61K,A61P,C07K

Abstract:
An antibody which specifically binds a polypeptide having IL-10 agonist activity, said binding inhibiting the agonist activity of said polypeptide, wherein said polypeptide consists of the following amino acid sequence: X.sub.1 -X.sub.2 -X.sub.3 -Thr-X.sub.4 -Lys-X.sub.5 -Arg-X.sub.6 (SEQ ID NO:22), wherein X.sub.1 is Ala or Gly; X.sub.2 is Tyr or Phe; X.sub.3, X.sub.4 and X.sub.5 are independently selected from the group consisting of Met, Ile, Leu and Val; and X.sub.6 is selected from the group consisting of Asn, Asp, Gln and Glu.