Patent ID: 6660753
Filing Date: 2003-12-09
Classification: C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein---- represents a double or single bond; X and Y are N; Z is O; Ar1 and Ar2 are independently selected from the group consisting of: optionally substituted phenyl and optionally substituted 2-pyridyl wherein at least one of Ar1 and Ar2 is phenyl and at least one of Ar1 and Ar2 is 2-pyridyl and at least one of Ar1 and Ar2 is substituted with at least one substituent G; wherein G is selected from the group consisting of: haloalkyl; pyridyl; thiophene; pyrimidine; furan; cycloalkene; alkenyl; alkynyl; A-alkenyl; A-alkynyl; A-alkyloxy; â€”R2OR3;â€”R2OC(O)R3; (CH2)mâ€”NR2R3; â€”OCH2CH(Cl)CH2Cl; and substituted aryl wherein the aryl substituent is R4, and wherein A is a linker selected from the group consisting of: CH2; O; NH; S; SO; SO2; NSO2; â€”OSO2; and â€”C(NR2)NR3; m is selected from 0 and 1; R2 and R3 may be independently selected from the group consisting of: H; alkyl; haloalkyl; alkyloxy; alkylamine; cycloalkyl; heterocycloalkyl; aryl; heteroaryl; alkylaryl; alkylheteroaryl; haloaryl; alkyloxyaryl; alkenylaryl; alkenyloxyaryl; and haloheteroaryl; and R4 is selected from the group consisting of: halo; â€”OR2; â€”SR2; â€”SOR2; â€”SO2R2; â€”SO2NR2R3; â€”R2OR3; â€”R2SR3; â€”OCOR2; â€”OCONR2R3; â€”NR2COR3; â€”NR2CO2R3; â€”CN; â€”NO2; â€”C(NR2)NR3; â€”CO2R2R3; â€”CONR2R3; â€”C(O)R2; â€”CH(OR2)R3; â€”CH2(OR2); â€”Aâ€”(CH2)mâ€”NR2R3; NR2R3; aryl; aralkyl; heteroaryl; and heteroaralkyl; and Ar1, Ar2, and the substituent G are optionally further substituted with one or more substituents selected independently from the group consisting of R2 and R4, with the proviso that when ---- represents a double bond, then either of Ar1 or Ar2 is pyridyl and the compound is not: 3-(2-pyridyl)-5-(4-aminophenyl)-1,2,4-oxadiazole, 3-(2-pyridyl)-5-{2-[2-(N,N,dimethylamino)-ethyl]oxyphenyl}-1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-chlorophenyl)-1,2,4-oxadiazole, or 3-(2-pyridyl)-5-phenyl-1,2,4-oxadiazole.