Patent ID: 7842292
Filing Date: 2010-11-30
Classification: A61K,A61P,C07K

Abstract:
1. A method for treatment of non-Hodgkin's lymphoma in a patient in need of such treatment comprising administering to the patient a composition comprising a fusion molecule selected from the group consisting of: 1) a fusion molecule comprising: (i) TACI extracellular domain wherein said TACI extracellular domain consists of the sequence of SEQ ID NO: 1, and (ii) a human immunoglobulin-constant domain; 2) a fusion molecule comprising amino acids 30-110 of SEQ ID NO: 1 and a human immunoglobulin-constant domain; 3) a fusion molecule consisting of amino acids 30-110 of SEQ ID NO: 1 and a human immunoglobulin-constant domain; and 4) a fusion molecule consisting of amino acids 30-110 of SEQ ID NO: 1 and the human immunoglobulin-constant domain of SEQ ID NO:2; wherein said composition is administered in an amount from 0.01 mg per 1 kg of patient's body weight to 10 mg per 1 kg of patient's body weight and wherein said composition is administered 5 times during a 4-week interval followed by administration of the composition on a weekly basis at least during 2 more additional weeks, and wherein said composition is administered subcutaneously or intravenously.