Patent ID: 6159940
Filing Date: 2000-12-12
Classification: A61K

Abstract:
A method of modulating hemopoiesis in an animal comprising administering to the animal an effective amount of one or more of the peptides of formula I:X--Glu--Trp--Y (I)wherein X is H, Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, His, Lys, Arg .gamma.-aminobutyric acid, or .xi.-aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, Arg, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, --OH, NH.sub.2, N.sub.2 H.sub.3, or a mono- or di-substituted amide (C.sub.1 -C.sub.3); with the proviso that when X is H, Y is not --OH and a pharmaceutically acceptable carrier.