Patent ID: 8206746
Filing Date: 2012-06-26
Classification: A61K,B82Y

Abstract:
1. A process for preparing solid microparticles of a water-insoluble or poorly water-soluble compound in an aqueous medium, which process consists essentially of: (a) adding particles of the water-insoluble or poorly water-soluble compound with at least one phospholipid and at least one surfactant that is not a phospholipid to a container to form a pre-mixture; (b) homogenizing the pre-mixture; (c) sonicating the pre-mixture to produce stable solid microparticles at a temperature between 16° C.-20° C.; and (d) adjusting the pH of the mixture during step b, step c or during both steps b and c˜wherein said water-insoluble or poorly water-soluble compound is a drug.