Patent ID: 6710042
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A compound of the formula in which:R1 and R2 together form a group â€”(CH2)4â€”; AR1 is a phenyl which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a hydroxyl, a (C1-C4)alkoxy, a (C1-C4)alkyl, a trifluoromethyl and a methylenedioxy, said substituents being identical or different; a thienyl which is unsubstituted or substituted by a halogen atom; a benzothienyl which is unsubstituted or substituted by a halogen atom; a naphthyl which is unsubstituted or substituted by a halogen atom; an indolyl which is unsubstituted or N-substituted by a (C1-C4)alkyl or a benzyl; an imidazolyl which is unsubstituted or substituted by a halogen atom; a pyridyl which is unsubstituted or substituted by a halogen atom; or a biphenyl; T is a group â€”CH2â€”; a group â€”COâ€”; a group â€”COOâ€”; or a group â€”CONR3â€” in which R3 is a hydrogen or a (C1-C4)alkyl; A is a direct bond; a group â€”(CH2)tâ€”, in which t is one, two or three; or a vinylene group; or â€”Tâ€”Aâ€” is the group â€”SO2â€”; Z is an optionally substituted, mono-, di- or tri-cyclic aromatic or heteroaromatic group; and B is a group B1 of the formula in which:x is zero or one; AR2 is a phenyl which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a nitro, a hydroxyl, a trifluoromethyl, a (C1-C4)alkyl, a (C1-C4)alkoxy and a methylenedioxy, said substituents being identical or different; a pyridyl; a thienyl; a pyrimidyl; or an imidazolyl which is unsubstituted or substituted by a (C1-C4)alkyl; and X1 is a group selected from: (1) hydrogen; (2) (C1â€”C7)alkyl; (3) formyl; (4) (C1-C7)alkylcarbonyl; (5) â€”(CH2)mâ€”R4; (6) â€”(CH2)mâ€”OCOR5; (7) â€”(CH2)mâ€”OCONHâ€”(C1-C7)alkyl; (8) â€”Oâ€”CH2CH2â€”OR6; (9) â€”(CH2)nâ€”SR7; (10) â€”CH2â€”S(O)jâ€”(C1-C7)alkyl; (11) â€”NR8R9; (12) â€”(CH2)pâ€”NR10R11; (13) â€”NR12COR13; (14) â€”NR14COCOR15; (15) â€”(CH2)pâ€”NR14C(&boxH;W1)R16; (16) â€”(CH2)mâ€”NR14COOR17; (17) â€”(CH2)mâ€”NR14SO2R18; (18) â€”(CH2)mâ€”NR14C(&boxH;W1)NR19R20; (19) â€”(CH2)nâ€”COOR21; (20) â€”(CH2)nâ€”C(&boxH;W1)NR19R20; (21) â€”COâ€”NR22â€”NR23R24; (22) â€”CN; â€ƒor X1 forms a double bond between the carbon atom to which it is bonded and the adjacent carbon atom of the piperidine ring; in which groups:m is zero, one or two; n is zero or one; p is one or two; j is one or two; W1 is an oxygen atom or a sulfur atom; R4 is a hydrogen or a (C1-C7)alkyl; R5 is a hydrogen; a (C1-C7)alkyl; a (C3-C7)cycloalkyl which is unsubstituted or substituted by one or more methyls; a phenyl; or a pyridyl; R6 is a hydrogen; a (C1-C7)alkyl; a formyl; or a (C1-C7)alkylcarbonyl; R7 is a hydrogen or a (C1-C7)alkyl; R8 and R9 are each independently a hydrogen or a (C1-C7)alkyl; R9 can also be a (C3-C7)cycloalkylmethyl, a benzyl or a phenyl; or R8 and R9, together with the nitrogen atom to which they are bonded, form a heterocycle selected from azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, perhydroazepine and piperazine which is unsubstituted or substituted in the 4-position by a (C1-C4)alkyl; R10 and R11 are each independently a hydrogen or a (C1-C7)alkyl; R11 can also be a (C3-C7)cycloalkylmethyl or a benzyl; R12 is a hydrogen or a (C1-C7)alkyl; R13 is a hydrogen; a (C1-C7)alkyl; a (C3-C7)cycloalkyl which is unsubstituted or substituted by one or more methyls; a phenyl; a benzyl; a vinyl; a pyridyl; a furyl; a thienyl; a pyrrolyl; or an imidazolyl; or R12 and R13 together are a group â€”(CH2)uâ€”, in which u is three or four; R14 is a hydrogen or a (C1-C7)alkyl; R15 is a (C1-C4)alkoxy; R16 is a hydrogen; a (C1-C7)alkyl; a (C3-C7)cycloalkyl which is unsubstituted or substituted by one or more methyls; a phenyl; a benzyl; a vinyl; a pyridyl; a furyl; a thienyl; a pyrrolyl; or an imidazolyl; R17 is a (C1-C7)alkyl or a phenyl; R18 is a (C1-C7)alkyl; an amino which is free or substituted by one or two (C1-C7)alkyls; or a phenyl which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a (C1-C7)alkyl, a trifluoromethyl, a hydroxyl, a (C1-C7)alkoxy, a carboxyl, a (C1-C7)alkoxycarbonyl, a (C1-C7)alkylcarbonyloxy, a cyano, a nitro and an amino which is free or substituted by one or two (C1-C7)alkyls, said substituents being identical or different; R19 and R20 are each independently a hydrogen or a (C1-C7)alkyl; R20 can also be a (C3-C7)cycloalkyl; a (C3-C7)cycloalkylmethyl; a hydroxyl; a (C1-C4)alkoxy; a benzyl; a phenyl; or a (C1-C7)alkyl substituted by a hydroxyl, a (C1-C3)alkoxy, a phenyl, a carboxyl, a (C1-C3)alkoxycarbonyl or a carbamoyl which is unsubstituted or substituted by one or two (C1-C7)alkyls; or R19 and R20, together with the nitrogen atom to which they are bonded, form a heterocycle selected from azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, perhydroazepine and piperazine which is unsubstituted or substituted in the 4-position by a (C1-C4)alkyl; R21 is a hydrogen or a (C1-C7)alkyl; R22 is a hydrogen or a (C1-C7)alkyl; R23 and R24 are each independently a hydrogen or a (C1-C7)alkyl; R25 is a hydrogen or a (C1-C7)alkyl; and R26 and R27 are each independently a hydrogen or a (C1-C7)alkyl; R27 can also be a formyl or a (C1-C7)alkylcarbonyl; in which AR2 is as defined above; in which AR2 is as defined above; in which AR2 is as defined above; in which:AR2 is as defined above; Am1 is an amino group substituted by two (C1-C4)alkyls; and r is two or three; in which:AR2 is as defined above; W2 is an oxygen atom; a sulfur atom; a sulfinyl; a sulfonyl; or a group â€”NL1â€”; L1 is a hydrogen; a (C1-C4)alkyl; a (C1-C4)alkylcarbonyl; or a group â€”(CH2)vâ€”Am2; v is one, two or three; and Am2 is an amino group which is unsubstituted or monosubstituted or disubstituted by a (C1-C4)alkyl; Am2 can also be a pyrrolidino, piperidino or morpholino group; or an acid-addition salt thereof.