Patent ID: 6294191
Filing Date: 2001-09-25
Classification: A61K,A61P,Y10S,Y10T

Abstract:
A pharmaceutical composition comprising:(a) a pharmaceutically acceptable carrier; and(b) a liposome having a lipid component which comprises:(i) an N-acyl phosphatidylethanolamine (NAPE) having the formula: ##STR3##(ii) an additional lipid,wherein:each of R.sup.1, R.sup.2 and R.sup.3 is independently a group having the formula --C(O)(CH.sub.2).sub.n1 (CH.dbd.CH).sub.n2 (CH.sub.2).sub.n3 (CH.dbd.CH).sub.n4 (CH.sub.2).sub.n5 (CH.dbd.CH).sub.n6 (CH.sub.2).sub.n7 (CH.dbd.CH).sub.n8 (CH.sub.2).sub.n9 CH.sub.3 ;n1 is zero or an integer equal to from 1 to 22;n3 is zero or an integer equal to from 1 to 19;n5 is zero or an integer equal to from 1 to 16;n7 is zero or an integer equal to from 1 to 13;n9 is zero or an integer equal to from 1 to 10;for each of R.sup.1 and R.sup.2 independently the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer equal to from 12 to 22, at least one of n2, n4, n6 and n8 is equal to 1;for R.sup.3 the sum of n1+2n2+n3+2n4+n5+2n6+n7+2n8+n9 is an integer equal to from 2 to 22;each of n2, n4, n6 and n8 is independently equal to 0 or 1;the lipid component comprises a destabilization-effective amount of the N-acyl phosphatidylethanolamine of at least about 25 mole %; wherein the liposome is multilamellar or is a large unilamellar liposome wherein the destabilization-effective amount of the NAPE is that amount of NAPE which renders the liposome fusogenic when the liposome is admixed with a target, in the presence of divalent cations or at a pH of about 4.9 to about 6.0.