Patent ID: 8334282
Filing Date: 2012-12-18
Classification: A61P,C07D

Abstract:
1. A method of treating a disease, comprising: administering to a mammal in need thereof a therapeutically effective amount of a compound, wherein the disease is selected from obesity, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, dyslipidemias, atherosclerosis, hypertension, stroke, heart attack, liver inflammation, liver fibrosis, NASH, fatty liver, enlarged liver, alcoholic liver disease, jaundice, cirrhosis, hepatitis, and a combination thereof, wherein the compound is of Formula I or Ia or a stereoisomer or pharmaceutically acceptable salt thereof: wherein: R R R alternatively, R R A is selected from H, C Z is selected from H, OH, C B is selected from H, C m, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; p, at each occurrence, is independently selected from 0, 1, and 2; q, at each occurrence, is independently selected from 0, 1, and 2; alternatively, the azetidine N-atom can be an N-oxide or quaternary ammonium salt when R R provided that when R further provided that when B is H, C