Patent ID: 6087346
Filing Date: 2000-07-11
Classification: C07C,C07D

Abstract:
A method of treating a human being suffering from, drug abuse, gastrointestinal disorder, hypertension, migraine, angina or depressionwhich comprises administering to said human a therapeutically effective amount of a compound of Formula I: ##STR61## wherein m is 0 or 1; n is 0, 1, 2, 3, 4, 5, or 6; R.sub.1 is selected from C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, indane, substituted indane, tetralin, substituted tetralin, benzocycloheptane, substituted benzocycloheptane, wherein the substituents are selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, hydroxy, C.sub.1-6 alkyl, trifluoromethyl;or wherein R.sub.1 is: ##STR62## R.sub.2 and R.sub.3 are each independently selected from hydrogen, hydroxy, C.sub.1-6 alkyl, or together two R.sub.2 and R.sub.3 groups may be a double bond between adjacent carbon atoms; R.sub.4 is hydrogen, C.sub.1-6 alkyl, substituted C.sub.1-6 alkyl, benzyl, C.sub.2-6 alkaryl, benzoyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, indane, substituted indane, tetralin, substituted tetralin, benzocycloheptane, substituted benzocycloheptane, wherein the substituents are selected from halogen, hydroxy, C.sub.1-6 alkyl; or wherein R.sub.4 is: ##STR63## and pharmaceutically acceptable salts thereof.