Patent ID: 6423729
Filing Date: 2002-07-23
Classification: A61K,A61P,C07C,C07D

Abstract:
A method for treating or preventing glomerulopathy which comprises administering an effective amount of a compound of Formula (I) and pharmaceutically acceptable carrier: wherein R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl; R3 is 1,4-phenylene or 2,5-thiophendiyl; R5 is hydrogen atom, hydroxy, optionally substituted lower alkyloxy, mercapto, lower alkylk thio, cycloalkyl, halogen, carboxy, lower alkyloxycarbonyl, nitro, cyano, lower hgaloalkyl, aryloxy, optionally substituted amino, guanidino, optionalyl substituted lower alkyl, lower alkenyl, lower alkynyl, acyl, acyoxy, â€”CONRARB, â€”N(RC)CORD (wherein RA, RB and RC are the same or different selected from hydrogen atom, lower alkyl and aralkyl; RD is lower alkyl, aryl or aralkyl), optionally substituted non-aromatic heterocyclic group, or optionally substituted heteroaryl; Y is NHOH or OH; its optically active substance, their pharmaceutically acceptable salt or hydrate thereof.