Patent ID: 6703002
Filing Date: 2004-03-09
Classification: A61K,A61Q

Abstract:
A topically applicable cosmetic/dermatological sunscreen composition suited for the UV-photoprotection of human skin and/or hair, comprising synergistically SPF-enhancing amounts of (a) 0.1 to 15% by weight, with respect to the total weight of the composition, of benzene-1,4-di(3-methylidene-10-camphorsulfonic acid), optionally in partially or completely neutralized state, and (b) 0.1 to 15% by weight, with respect to the total weight of the composition, of at least one amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I): in which R1 and R2, which may be identical or different, are each a hydrogen atom, a C1-C20 alkyl radical, a C2-C10 alkenyl radical, a C3-C10 cycloalkyl radical or a C3-C10 cycloalkenyl radical, with the proviso that R1 and R2 can together form, with the nitrogen atom to which they are bonded, a 5- or 6-membered heterocyclic ring member; R3 and R4, which may be identical or different, are each a C1-C20 alkyl radical, a C2-C10 alkenyl radical, a C3-C10 cycloalkyl radical, a C3-C10 cycloalkenyl radical, a C1-C12 alkoxy radical, a (C1-C20) alkoxycarbonyl radical, a C1-C12 alkylamino radical, a di(C1-C12) alkylamino radical, an aryl radical or a heteroaryl radical which is optionally substituted, or a water-solubilizing substituent selected from among a carboxylate group, a sulfonate group or an ammonium residue; X is a hydrogen atom or a â€”COOR5 or â€”CONR6R7 radical; R5, R6 and R7, which may be identical or different, are each a hydrogen atom, a C1-C20 alkyl radical, a C2-C10 alkenyl radical, a C3-C10 cycloalkyl radical, a C3-C10 cycloalkenyl radical, a â€”(YO)oâ€”Z radical or an aryl radical; Y is â€”(CH2)2â€”, â€”(CH2)3â€”, â€”(CH2)4â€” or â€”CHâ€”CH3â€”CH2â€”; Z is â€”CH2â€”CH3, â€”CH2CH2CH3, â€”CH2â€”CH2â€”CH2â€”CH3 or â€”CH(CH3)â€”CH3; m is an integer ranging from 0 to 3; n is an integer ranging from 0 to 3; o is an integer ranging from 1 to 2, formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor, and further wherein the benzene-1,4-di(3-methylidene-10-camphorsulfonic acid) and the amino-substituted 2-hydroxybenzophenone compound having structural formula (I) are present in a proportion or in such amounts that provide synergistic results with regard to the sun protection factors conferred.