Patent ID: 7314760
Filing Date: 2008-01-01
Classification: G01N

Abstract:
1. A method for detecting the presence or absence of Down's syndrome in a fetus of a pregnant woman to be tested comprising the steps of: a. obtaining a urine sample from said pregnant woman to be tested; b. determining a percentage of invasive trophoblast antigen (ITA) having a pI ranging from 5.0 to 7.0 present of a total amount of ITA having a pI ranging from 3.0 to 7.0 in the urine sample; and c. comparing the percentage obtained in step b with a predetermined value obtained by determining a percentage of ITA having a pI ranging from 5.0 to 7.0 of a total amount of ITA having a pI ranging from 3.0 to 7.0 in sample(s) from at least ten pregnant woman carrying a normal fetus of the same gestational age as said fetus of said pregnant woman to be tested, wherein said percentage obtained in step b which is at least 1.5 times the predetermined value is predictive of Down's syndrome.