Patent ID: 7473561
Filing Date: 2009-01-06
Classification: A61K,C12N,G01N

Abstract:
1. A method for identifying a candidate agent for use in reducing vascularization in non-small cell lung tumors comprising: (a) contacting bone morphogenetic protein-2 (BMP-2) and BMP-2 receptor IB in the presence of a test agent under conditions suitable to permit the formation of a BMP-2/BMP-2 receptor complex, wherein said BMP-2 comprises the amino acid sequence of amino acids 283-396 of SEQ ID NO: 2 and wherein said BMP-2 receptor IB comprises the amino acid sequence of amino acids 14-502 of SEQ ID NO: 14; (b) determining the amount of the BMP-2/BMP-2 receptor complex formed in the presence of said test agent; and (c) determining that said test agent is a candidate agent for use in reducing vascularization in non-small cell lung tumors if the amount of the BMP-2/BMP-2 receptor complex formed in the presence of said test agent is lower than the amount of the BMP-2/BMP-2 receptor complex formed in the absence of said test agent, thereby identifying a candidate agent for use in reducing vascularization in non-small cell lung tumors.