Patent ID: 8673355
Filing Date: 2014-03-18
Classification: A61K,A61P,Y10S

Abstract:
1. A sustained release oral dosage form, comprising: an orally therapeutically effective dose of an opioid agonist selected from morphine, hydromorphone, hydrocodone, oxycodone, codeine, levorphanol, meperidine, methadone, and mixtures thereof, or a pharmaceutically acceptable salt thereof; an opioid antagonist selected from naltrexone, naloxone, nalmephene, cyclazocine, levallorphan, and mixtures thereof, or a pharmaceutically acceptable salt thereof; and a sustained release carrier incorporated into a matrix that contains the opioid agonist and the opioid antagonist; said dosage form having a ratio of opioid antagonist to opioid agonist that provides a combination product which is analgesically effective when the combination is administered orally, but which such that said dosage form is administrable on a twice-a-day or on a once-a-day basis.