Patent ID: 6521658
Filing Date: 2003-02-18
Classification: A61P,C07C,C07D

Abstract:
A compound having formula (I) or a pharmaceutically acceptable salt or prodrug thereof, whereinL1 is shown with its left end attached to R1 and its right end attached to the phenyl ring and is â€”SO2NR7â€”, wherein R7 is selected from the group consisting of (a) hydrogen, (b) hydroxy, (c) amidinyl, (d) a nitrogen-protecting group, (e) alkanoyl, (f) alkyl, (g) alkenyl, (h) alkynyl, (i) cycloalkyl, (j) cycloalkylalkyl, (k) cycloalkenyl, (l) cycloalkenylalkyl, (m) aryloyl, (n) alkoxy, â€ƒwherein (e)-(n) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (i) hydroxyl, (ii) halo, (iii) cyano, (iv) azido, (v) carboxy, (vi) amidinyl, (vii) alkyl, (viii) aryl, (ix) oxo, (x) heteroaryl, (xi) heterocycloalkyl, (xii) â€”NRcRd, wherein Rc and Rd are independently selected from the group consisting of (1â€²) hydrogen, (2â€²) alkyl, (3â€²) aryl, and (4â€²) alkoxyalkyl, and (xiii) -(alkylene)â€”NRcRd, â€ƒwherein for (x) and (xi), the heteroaryl and the heterocycloalkyl can be optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of (1â€²) alkyl, and (2â€²) a nitrogen protecting group, (o) heterocycloalkyloyl, wherein the heterocycloalkyloyl can be optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of (i) alkyl, and (ii) a nitrogen protecting group, and (p) â€”(CH2)xNRARB wherein x is 0-6, and RA and RB are independently selected from the group consisting of (i) hydrogen, (ii) alkyl, (iii) alkenyl, (iv) alkynyl, (v) cycloalkyl, (vi) cycloalkylalkyl, (vii) cycloalkenyl, and (viii) cycloalkenylalkyl; R1 is indolyl, wherein the indolyl can be optionally substituted with 1, 2, 3, 4,or 5 substituents independently selected from the group consisting of (a) oxo, (b) azido, (c) carboxy, (d) carboxaldehyde, (e) cyano, (f) halo, (g) hydroxy, (h) nitro, (i) perfluoroalkyl, (j) perfluoroalkoxy, (k) alkyl, (l) alkenyl, (m) alkynyl, (n) alkanoyloxy, (o) alkoxycarbonyl, (p) cycloalkyl, (q) cycloalkylalkyl, (r) cycloalkenyl, (s) cycloalkenylalkyl, (t) alkanoyl, (u) alkoxy, (v) cycloalkoxy, (w) aryloxy, (x) heteroaryloxy, (y) thioalkoxy (z) alkylsulfinyl, (aa) alkylsulfonyl, (bb) â€”NR8R9, wherein R8 and R9 are independently selected from the group consisting of (i) hydrogen (ii) alkyl, (iii) arylalkyl, and (iv) alkanoyl, wherein the alkanoyl can be optionally substituted with 1 or 2 substituents independently selected from the group consisting of (1â€²) halo (2â€²) hydroxy, and (3â€²) â€”NR10R11 wherein R10 and R11 are independently hydrogen or alkyl, and (cc) â€”SO2NR8R9, wherein R8 and R9 are defined above; R2 and R6 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, (3) alkoxy, (4) thioalkoxy; and (5) hydroxy; and R3, R4, and R5 are independently selected from the group consisting of (1) alkyl, (2) alkoxy, (3) thioalkoxy, and (4) hydroxy.