Patent ID: 6825236
Filing Date: 2004-11-30
Classification: A61P,C07C,C07D,C07H

Abstract:
A compound represented by the formula whereinR is C(O)â€”(CHR4)mâ€”Aâ€”R1 where m is 1-10, A is S, O, N or a covalent bond, R1 is substituted phenyl, wherein the phenyl is substituted with from one to five substituents independently selected from the group consisting of halo, lower alkyl of 1-6 carbons, hydroxy, lower alkoxy of 1-6 carbons, cyano, nitro, amino, halogenated lower alkyl of 1-6 carbons, halogenated lower alkoxy of 1-6 carbons, carbonyl, hydroxycarbonyl, lower alkylcarbonyloxy of 1-6 carbons, benzyloxy; optionally substituted 5 membered heterocyclic ring optionally substituted with one or two substituents selected from the group consisting of halo, lower alkyl of 1-6 carbons, lower alkoxy of 1-6 carbons, hydroxy, cyano, nitro, amino, halogenated lower alkyl of 1-6 carbons, halogenated lower alkoxy of 1-6 carbons, hydroxycarbonyl, lower alkoxycarbonyl of 1-6 carbons, lower alkylcarbonyloxy of 1-6 carbons, and lower alkylcarbonylamino of 1-6 carbons; optionally substituted 6 membered heterocyclic ring optionally substituted with one or two substituents selected from the group consisting of halo, lower alkyl of 1-6 carbons, lower alkoxy of 1-6 carbons, hydroxy, cyano, nitro, amino, halogenated lower alkyl of 1-6 carbons, halogenated lower alkoxy of 1-6 carbons, hydroxycarbonyl, lower alkoxycarbonyl of 1-6 carbons, lower alkylcarbonyloxy of 1-6 carbons, lower alkylcarbonylamino of 1-6 carbons, or optionally substituted phenyl or benzyl; an imide ring, lower alkoxycarbonyl of 1-6 carbons, and lower alkylcarbonylamino of 1-6 carbons, or substituted benzoyl, wherein the benzoyl is substituted with from one to five substituents independently selected from the group consisting of halo, lower alkyl of 1-6 carbons, hydroxy, lower alkoxy of 1-6 carbons, cyano, nitro, amino, halogenated lower alkyl of 1-6 carbons, halogenated lower alkoxy of 1-6 carbons, carbonyl, hydroxycarbonyl, lower alkylcarbonyloxy of 1-6 carbons, benzyloxy, optionally substituted 5 membered heterocyclic ring, optionally substituted 6 membered heterocyclic ring, an imide ring, lower alkoxycarbonyl of 1-6 carbons, and lower alkylcarbonylamino of 1-6 carbons; B is methoxy or methylthio, R2 is methoxy, hydroxy, or methylenedioxy when taken together with R3; and R3 is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R2; and m is H or is H or methyl when m is 1.