Patent ID: 6150339
Filing Date: 2000-11-21
Classification: A61K,A61P,C07H,C12N

Abstract:
A method of inhibiting the production of HIV-1 in cultured cells comprising contacting said virus with an oligonucleotide having a sequence chosen from the group consisting of5'-gtggtgggtgggtgggg-3' (SEQ ID NO 46)5'-gtggtgggtgggtggg-3' (SEQ ID NO 47)5'-tggtgggtgggtgggt-3' (SEQ ID NO 48)5'-gtggtgggtgggt-3' (SEQ ID NO 49)5'-gtggtgggt-3' (SEQ ID NO 50)5'-gtgggtgggtgggt-3' (SEQ ID NO 51)5'-gtgggtgggt-3' (SEQ ID NO 52),optionally modified at the 3' terminus by attachment of a substituent moiety selected from the group consisting of propylamine, polyamine, poly-L-lysine, and cholesterol,optionally modified at the 5' terminus by attachment of a substituent moiety selected from the group consisting of propylamine, polyamine, poly-L-lysine, and cholesterol, andoptionally modified by replacement of at least one phosphodiester moiety with a phosphorothioate moiety.