Patent ID: 8568728
Filing Date: 2013-10-29
Classification: A61K,A61P,Y02A

Abstract:
1. A method for treating cancer comprising administering to a patient having cancer a therapeutically effective amount of a ligand drug conjugate compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: L- is a Ligand Unit selected from the group consisting of a protein, a polypeptide, and a peptide that specifically binds to an antigen expressed on cells of the cancer; -A -A- is an optional Stretcher Unit, a is 0, 1 or 2; each —W— is independently a Glucuronide Unit having one of the formulae: Su is a Sugar moiety, —O′— represents an oxygen atom of an O-glycosidic bond cleavable by beta-glucoronidase; each R is independently hydrogen, a halogen, —CN, or —NO w is 1, —Y— is an optional Self-Immolative Spacer Unit, y is 0, 1 or 2; p ranges from 1 to 20; and -D is a Drug Unit selected from the group consisting of a cytotoxic, a cytostatic and an immunomodulatory drug and wherein the wavy lines indicate covalent bonds within the rest of the compound.