Patent ID: 6811767
Filing Date: 2004-11-02
Classification: A61K,A61P,Y10S

Abstract:
An aerosol composition of an aqueous dispersion of nanoparticulate drug particles, wherein:(a) essentially each droplet of the aerosol comprises at least one nanoparticulate drug particle, wherein (i) the drug has a solubility in said aqueous dispersion of less than about 10 mg/mL; (ii) the drug is selected from the group consisting of, naproxen, triamcinolone acetonide, budesonide, and an anti-emetic; and (iii) the drug is present in a concentration of from about 0.05 mg/mL up to about 600 mg/mL; (b) the droplets of the aerosol have a mass median aerodynamic diameter (MMAD) less than or equal to about 100 microns; (c) the nanoparticulate drug particles have an effective average particle size of less than about 1000 nm, and have a surface modifier adsorbed on the surface of the drug, and (d) the aerosol composition can administer a drug dosage in less than about 15 seconds.