Patent ID: 6469026
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A compound represented by the formula: wherein:A is a member selected from the group consisting of: R2, â€”NR3R4, where R2, R3, R4, R5, R6, R7, R8, and R9 are independently selected from the group consisting of H, â€”OH, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C6-12carbocyclic aryl, a five to ten membered heterocyclic ring system containing 1-4 heteroatoms selected from the group consisting of N, O and S, and C1-6alkylheterocyclic ring system having in the ring system 5 to 10 atoms with 1 to 4 of such atoms being selected from the group consisting of N, O and S; where R6 taken with either of R7 and R8, and/or R7 taken with R8, can each form a 5 to 6 membered heterocyclic ring containing from 1 to 4 atoms selected from the group consisting of N, O and S;m is an integer from 0-3; Z is a member selected from the group consisting of a direct link, C1-6alkyl, C3-8cycloalkyl, C1-6alkenyl, aryl, or a five to ten membered heterocyclic ring system containing 1-4 heteroatoms selected from the group consisting of N, O and S; n is an integer from 0-3; R1 is a member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, halogen, polyhaloalkyl, C0-8alkyl-C(&boxH;O)OH, C0-8alkyl-C(&boxH;O)Oâ€”C1-8alkyl, â€”CN, â€”NO2, C0-8alkyl-OH, C0-8alkyl-SH, â€”Oâ€”R2 and â€”Oâ€”C(&boxH;O)R2, an unsubstituted amino group, a mono- or di-substituted amino group, wherein the substituted amino groups are independently substituted by at least one member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, polyhaloalkyl, C0-8alkyl-C(&boxH;O)OH and C0-8alkyl-C(&boxH;O)Oâ€”C1-8alkyl, where R2 is as set forth above; q is an integer from 0-3; X is â€”NR12â€” or â€”CHR12â€”; R11 and R12 are independently a member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C6-12carbocyclic aryl, C1-6alkylaryl, C1-6alkyl-C3-8cycloalkyl, â€”Oâ€”R2, â€”Oâ€”C(&boxH;O)R2, â€”C1-8alkyl-Oâ€”R10, C1-8alkyl-Oâ€”C(&boxH;O)R10, â€”C1-8alkyl-Oâ€”C(&boxH;O)OR10, â€”C1-8alkyl-C(&boxH;O)NR10R10, â€”C1-8alkyl-NR10R10, â€”C1-8alkyl-NR10C(&boxH;O)R10, and â€”SR10, wherein R10 is a member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, and wherein when two R10 groups are present they may be taken together to form a saturated or unsaturated ring with the atom to which they are both attached; p is an integer from 0-3; E is â€”CH(CO2R11)(CH2)0-3â€”, where R11 is as described above, phenylene, a 5 to 12 membered bivalent heteroaryl group containing 1 to 4 heteroatoms selected from the group consisting of N, O and S, and a five to ten membered non-aromatic heterocyclic ring system containing 1-4 heteroatoms selected from the group consisting of N, O and S, wherein said heteroaryl and said non-aromatic heterocyclic ring structure may be independently substituted by from 0 to 5 R14 groups; R14 is a member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, halogen, polyhaloalkyl, C0-8alkyl-C(&boxH;O)OH, C0-8alkyl-C(&boxH;O)Oâ€”C1-8alkyl, â€”CN, â€”NO2, C0-8alkyl-OH, C1-8alkyl-SH, â€”Oâ€”R2 and â€”Oâ€”C(&boxH;O)R2, an unsubstituted amino group, a mono- or di-substituted amino group, wherein the substituted amino groups are independently substituted by at least one member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, polyhaloalkyl, C0-8alkyl-C(&boxH;O)OH and C0-8alkyl-C(&boxH;O)Oâ€”C1-8alkyl, where R2 is as set forth above; J is a member selected from the group consisting of a C3-8cycloalkyl, phenylene, naphthalene, a 5 to 12 membered bivalent heteroaryl group containing 1 to 4 heteroatoms selected from the group consisting of N, O and S, and a five to ten membered non-aromatic bivalent heterocyclic ring system containing 1-4 heteroatoms selected from the group consisting of N, O and S wherein said heteroaryl and said non-aromatic heterocyclic ring structure may be independently substituted by from 0 to 5 R14 groups where each R14 group is as set forth above; G is a member selected from the group consisting of: H, â€”CN, â€”OR17, whereint is an integer from 0 to 6; u is the integer 0 or 1; and R17, R18, R19, R20, R21, R22, R23, R24, R25 and R26 are independently selected from the group consisting of H, â€”OH, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C6-12carbocyclic aryl, a five to ten membered heterocyclic ring system containing 1-4 heteroatoms selected from the group consisting of N, O and S, and C1-6alkylheterocyclic ring system having in the ring system 5 to 10 atoms with 1 to 4 of such atoms being selected from the group consisting of N, O and S; where R18 taken with R19, R22 taken with either of R24 and R25, and R24 taken with R25, can each independently form a 5 to 6 membered heterocyclic ring containing from 1 to 4 atoms selected from the group consisting of N, O and S; with the proviso that when G is H, â€”CN, or â€”OR17 either E or J must contain at least one N atom; and all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives thereof.