Patent ID: 6043098
Filing Date: 2000-03-28
Classification: A61K,Y02A

Abstract:
A method for preventing unwanted cellular growth associated with the use of implants comprising:implanting a selenium-coated device at a desired target site, said site having endogenous thiol compounds, wherein said selenium-coated device comprises (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are the same or different and each is an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, phosphate, sulfate, halogen, phenolic reactive groups and combinations thereof, attached to (ii) an insoluble non-metallic implant having a surface constituent which forms a bond with said reactive groups of said selenium compound to produce said selenium coated device, for the localized generation of superoxide for localized destruction of unwanted growth at said target site.