Patent ID: 6258792
Filing Date: 2001-07-10
Classification: C07J

Abstract:
A nucleic acid:lipid complex for transfecting nucleic acids into cells, said complex comprising a nucleic acid and a compound having the structure:X--R.sub.2 --R.sub.1 --O-Cholesteryl, whereinR.sub.1 is a linker bond ##STR10##R.sub.2 is a direct bond, a branched or linear alkylene or alkenylene chain of 1 to 10 carbons in length, a C.sub.3 -C.sub.7 cycloalkylene, or a phenylene;X is a 4-7-membered nitrogen-containing cyclic structure; andX is linked to the R.sub.2 spacer via a carbon atom of the nitrogen-containing cyclic structure or via a nitrogen atom of the cyclic structure.