Patent ID: 8252952
Filing Date: 2012-08-28
Classification: B01J,C07B,C07C,C07D

Abstract:
1. A method for stereoselectively producing a compound represented by Formula (VI): comprising: a step of alkylating a compound represented by Formula (IV): with a compound of Formula (V): using a compound represented by Formula (I) that is pure with respect to its axial asymmetry as a phase-transfer catalyst: in a medium in the presence of an inorganic base, wherein in Formula (I), R 2 and R 2′ are each independently: a hydrogen atom; or an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R 3 and R 3′ are each independently: a C R 4 and R 4′ are each independently a group selected from the group consisting of: (i) a hydrogen atom; (ii) a halogen atom; (iii) a C (iv) a C (v) a C (vi) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (vii) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R 7 and R 8 are each independently a monovalent organic group, or R 7 and R 8 are taken together to form a divalent organic group, and X − is a halide anion; in Formulae (IV) and (VI), R 14 and R 15 are each independently: (i) a hydrogen atom; or (ii) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: with the proviso that a case where R R 16 is a group selected from the group consisting of: (i) a hydrogen atom; (ii) a C (iii) a C (iv) a C (v) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (vi) an aryl group, wherein the aryl group may be substituted with at least one group selected from the group consisting of: R 17 is a C 1 to C 8 alkyl group that may be branched or form a cyclic group, in Formulae (V) and (VI), R 18 is a group selected from the group consisting of: (i) a C (ii) a C (iii) a C (iv) an aralkyl group, wherein the aryl moiety constituting the aralkyl group may be substituted with at least one group selected from the group consisting of: (v) a C in Formula (V), W is a functional group having a leaving ability, and in Formula (VI), * indicates a newly produced asymmetric center.