Patent ID: 7094408
Filing Date: 2006-08-22
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A method of potentiating a CD8+ response to human immunodeficiency virus-1 (HIV-1) epitopes in a human comprising: administering an expression vector encoding HIV-1 Gag, Pol, Pro, Tat, Nef, Rev, Vif, Vpr or Env antigens; and administering a recombinant NYVAC pox virus encoding the same antigens encoded by the expression vector; wherein the expression vector and the recombinant pox virus enter the cells of the human and intracellularly produce HIV peptides that are presented on the cell's MHC class I molecules in an amount sufficient to stimulate a CD8+ response, and further, wherein administration of the combination of the expression vector and the recombinant pox virus potentiates the immune response compared to administration of either the expression vector or the recombinant pox virus by itself.