Patent ID: 8735392
Filing Date: 2014-05-27
Classification: A61P,C07D

Abstract:
1. A crystalline form of (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt, where the crystalline form exhibits at least one of: a solid state a differential scanning calorimetry thermogram having an endotherm with a maximum at between about 320° C. and about 335° C.; a thermogravimetric analysis thermogram indicative of an unsolvated material; a dynamic vapor sorption isotherm plot which does not exhibit a significant weight change from 0 to 95% relative humidity; an X-ray powder diffraction pattern comprising characteristic peaks expressed in d-values (Å) of about 11.9, 5.9, 4.9, 4.4, 4.3, 3.9, and 3.7; and an X-ray powder diffraction pattern comprising peaks at 2θ angle degrees±0.2 2θ angle degrees of 7.4, 15.1, 18.1, 20.1, 20.4, 22.6, and 24.0.