Patent ID: 6156761
Filing Date: 2000-12-05
Classification: C07D

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR13## where A is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, arylC.sub.1-6 alkyl, aryl, S(O).sub.p (CH.sub.2).sub.n R.sup.1, OR.sup.1, NR.sup.1 R.sup.12 or OS(O).sub.l R.sup.1 ;B is a 6-membered aromatic ring containing 1 nitrogen atom, which ring is optionally substituted by one or more substituents independently chosen from: C.sub.1-6 alkyl; C.sub.1-6 haloalkyl; C.sub.1-6 alkoxy; hydroxy; halogen; S(O).sub.r R.sup.4 ; COR.sup.5 ; and aryl or arylC.sub.1-6 alkyl wherein the aryl ring is optionally substituted by one, two or three substituents independently chosen from halogen, CF.sub.3, OCH.sub.3, nitro and cyano; and the N atom of the 6-membered aromatic ring is optionally substituted by an O atom;R.sup.1 is hydrogen; C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or C.sub.3-6 cycloalkenyl each of which is optionally substituted by amino, aminocarbonyl, C.sub.1-6 alkylamino, di(C.sub.1-6 alkyl)amino, C.sub.1-6 alkoxy, C.sub.1-6 alkylaminocarbonyl, one, two or three hydroxy groups, one, two or three halogen atoms or a four, five or six-membered saturated heterocyclic ring containing a nitrogen atom and optionally either an oxygen atom or a further nitrogen which ring is optionally substituted by C.sub.1-6 alkyl on the further nitrogen atom or by an oxo group on a carbon atom; aryl, arylC.sub.1-6 alkyl, arylC.sub.1-6 alkenyl or arylC.sub.2-6 alkynyl optionally substituted on the aryl ring by C.sub.1-6 alkyl, halogen, nitro, cyano, C.sub.1-6 alkylcarbonylamino, hydroxy or C.sub.1-6 alkoxy; or a five-membered aromatic ring containing 1, 2, 3 or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N, or a six-membered aromatic ring containing 1, 2, 3 or 4 nitrogen atoms, which ring is optionally substituted by halogen, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, aryl, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl;R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl or together with the carbon atom to which they are attached form a C.sub.3-8 cycloalkyl group;R.sup.4 is NR.sup.6 R.sup.7, C.sub.1-6 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, aryl or CH.sub.2 (CO).sub.m NR.sup.8 R.sup.9 ;R.sup.5 is NR.sup.6 R.sup.7, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;R.sup.6 is independently as defined for R.sup.4 ;R.sup.7 is aryl optionally substituted by halogen, nitro or cyano;R.sup.8 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkenyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, arylC.sub.1-6 alkyl, arylC.sub.2-6 alkenyl or arylC.sub.2-6 alkynyl optionally substituted on the aryl ring by halogen, nitro or cyano; thiophene or pyridine;R.sup.9 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl; or phenyl optionally substituted by one, two or three substituents independently chosen from halogen, CF.sub.3, OCH.sub.3, nitro and cyano;R.sup.12 is hydrogen or C.sub.1-6 alkyl;l is zero, 1 or 2;m is zero or 1;n is 0, 1 or 2;p is zero, 1 or 2;q is 0, 1 or 2; andr is 0, 1 or 2.