Patent ID: 6087373
Filing Date: 2000-07-11
Classification: A61P,C07D

Abstract:
A compound having the following structure: ##STR54## wherein X is O or H.sub.2 ;R.sup.1 and R.sup.2 are independently selected from the group consisting ofhydrogen,C.sub.1-6 alkyl-,C.sub.2-6 alkenyl,C.sub.2-6 alkynyl,C.sub.3-8 cycloalkyl-C.sub.3-8 cycloalkyl C.sub.1-6 alkyl-,di(C.sub.3-8 cycloalkyl) C.sub.1-6 alkyl-,aryl,aryl C.sub.1-6 alkyl-,di(aryl) C.sub.1-6 alkyl-,wherein aryl is an unsaturated 6-carbon ring, either unsubstituted or substituted with --OH, --NH.sub.2, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, or halogen;andQ is ##STR55## wherein R.sup.4 and R.sup.5 are independently selected from the group consisting ofhydrogen,C.sub.1-4 alkyl,C.sub.2-4 alkenyl,C.sub.2-4 alkynyl,C.sub.1-4 alkoxy,halogen,--COOH,--OH,--COOR.sup.7, where R.sup.7 is C.sub.1-4 alkyl,--CONR.sup.8 R.sup.9, where R.sup.8 and R.sup.9 are independently hydrogen or C.sub.1-4 alkyl,--OCH.sub.2 CO.sub.2 H,--OCH.sub.2 CO.sub.2 CH.sub.3,--OCH.sub.2 CO.sub.2 (CH.sub.2).sub.1-3 CH.sub.3,--O(CH.sub.2).sub.1-3 C(O)NR.sup.10 R.sup.11, wherein R.sup.10 and R.sup.11 are independently hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, or --CH.sub.2 CF.sub.3,--(CH.sub.2).sub.1-4 OH,--NHC(O)CH.sub.3,--NHC(O)CF.sub.3,--NHSO.sub.2 CH.sub.3,--SO.sub.2 NH.sub.2 ;or Q is ##STR56## wherein R.sup.6 and R.sup.12, same or different, are hydrogen,C.sub.1-6 alkyl-,C.sub.2-6 alkenyl-,C.sub.2-6 alkynyl,C.sub.3-8 cycloalkyl-,aryl,aryl C.sub.1-6 alkyl-wherein aryl is an unsaturated 6-carbon ring either unsubstituted or substituted with --OH, --NH.sub.2, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, or halogen.or a pharmaceutically acceptable salt thereof.