Patent ID: 6274613
Filing Date: 2001-08-14
Classification: A01N,A61K,A61P,C07D,C07K

Abstract:
Compounds of the formula (I) ##STR106##in whichn represent 1Ar.sup.1 represents the radical ##STR107##andAr.sup.2 represents the radical ##STR108##in whichm represents 0, 1, 2, 3 or 4,R.sup.1 represents halogen, cyano, nitro, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, alkoxyalkyl, --S(O).sub.o R.sup.6 or --NR.sup.7 R.sup.8,R.sup.2 and R.sup.3 independently of one another each represent hydrogen, halogen, cyano, nitro, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, alkoxyalkyl, --S(O).sub.o R.sup.6 or --NR.sup.7 R.sup.8,R.sup.4 represents halogen, cyano, trialkylsily, --CO--NR.sup.10 R.sup.11, tetrahydropyranyl or one of the groupings below(l) --X--A(m) --B--Z--D(n) --Y--E,R.sup.5 represents hydrogen, halogen, cyano, nitro, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, alkoxyalkoxy or --S(O).sub.o R.sup.6,o represents 0, 1 or 2,R.sup.6 represents alkyl or halogenoalkyl,R.sup.7 and R.sup.8 independently of one another each represent hydrogen or alkyl, or together represent alkylene,R.sup.10 and R.sup.11 independently of one another each represent hydrogen, alkyl, halogenoalkyl or represent phenyl or phenylalkyl, each of which is optionally mono- or polysubstituted by radicals from the list W.sup.1,X represents a direct bond, oxygen, sulphur, carbonyl, carbonyloxy, oxycarbonyl, alkylene, alkenylene, alkinylene, alkyleneoxy, oxyalkylene, thioalkylene, alkylenedioxy or di-alkylsilylene,A represents phenyl, naphthyl or tetrahydronaphthyl, each of which is optionally mono or polysubstituted by radicals from the list W.sup.1, or represents 5- to 10-membered heterocyclyl having one or more hetero atoms from the group consisting of nitrogen, oxygen and sulphur and containing 1 or 2 aromatic rings, which is optionally mono- or polysubstituted by radicals from the list W.sup.2,B represents p-phenylene which is optionally mono- or disubstituted by radicals from the list W.sup.1,Z represents oxygen or sulphur,D represents hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, respectively optionally halogen-, alkyl-, alkenyl-, halagenoalkenyl-, phenyl-, styryl-, halogenophenyl- or halogenostyryl-substituted cycloalkyl or cycloalkylalkyl, represents respectively optionally halogen- or alkyl-substituted cycloalkenyl or cycloalkenylalkyl, represents respectively optionally nitro-, halogen-, alkyl-, alkoxy-, halogenoalkyl- or halogenoalkoxy-substituted phenylalkyl, naphthylalkyl, tetrahydronaphthylalkyl or 5- or 6-membered hetarylalkyl having 1 or 2 hetero atoms from the group consisting of nitrogen, oxygen and sulphur, represents --CO--R.sup.12, --CO--NR.sup.13 R.sup.14 or represents the grouping--(CH.sub.2).sub.p --(CR.sup.15 R.sup.16).sub.q --(CH.sub.2).sub.r --G, orZ and D together represent optionally, nitro-, halogen-, alkyl, alkoxy-, halogenoalkyl- or halogenoalkoxy-substituted phenoxyalkyl,Y represents a direct bond, oxygen, sulphur, carbonyl, carbonyloxy, oxycarbonyl, alkylene, alkenylene, alkinylene, alkyleneoxy, oxyalkylene, thioalkylene, alkylenedioxy or represents p-phenylene which is optionally moon- or disubstituted by radicals from the list W.sup.1,E represents hydrogen, alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, respectively optionally halogen-, alkyl-, alkenyl-, halogenoalkenyl-, phenyl-, styryl-, halogenophenyl or halogenostyryl-substituted cycloalkyl, represents respectively optionally halogen- or alkyl-substituted cycloalkenyl, represents phenyl which is optionally mono- to tetrasubstituted by radicals from the list W.sup.1 or represents a 5- or 6-membered hotaryl having 1 or 2 hetero atoms from the group consisting of nitrogen, oxygen and sulphur, which is optionally mono- to tetrasubstituted by radicals from the list W.sup.2, or represents the grouping--(CH.sub.2).sub.p --(CR.sup.15 R.sup.16).sub.q --(CH.sub.2).sub.r --G,R.sup.12 represents alkyl, alkoxy, alkenyl, alkenyloxy, respectively optionally halogen-, alkyl-, alkenyl-, halogenoalkyl- or halogenoalkenyl-substituted cycloalkyl, cycloalkyloxy or cycloalkylalkyloxy or represents respectively optionally nitro-, halogen-, alkyl-, alkoxy-, halogenoalkyl- or halogenoalkoxy-substituted phenyl or naphthyl,R.sup.13 represents hydrogen or alkyl,R.sup.14 represents alkyl, halogenoalkyl, respectively optionally halogen-, alkyl-, alkenyl-, halogenoalkyl- or halogenoalkenyl-substituted cycloalkyl, cycloalkylalkyl or represents respectively optionally halogen-, alkyl-, alkoxy-, halogenoalkyl- or halogenoalkoxy-substituted phenyl or phenylalkyl,p, q and r independently of one another each represent 0, 1, 2 or 3, their sum being smaller than 6,R.sup.15 and R.sup.16 independently of one another each represent hydrogen or alkyl,G represents cyano, represents a 5- or 6-membered heterocycle having 1 to 3 identical or different hetero atoms from the group consisting of nitrogen, oxygen and sulphur, which is optionally substituted by halogen, alkyl or halogenoalkyl and, at the attachment point, optionally by the radical R.sup.17, or represents one of the groupings below(a) --CO--R.sup.17(b) --CO--OR.sup.18(c) --CO--NR.sup.19 R.sup.20(d) --CS--NR.sup.19 R.sup.20 ##STR109##R.sup.17 represents hydrogen, alkyl, alkenyl, halogenoalkyl, halogenoalkenyl, optionally halogen-, alkyl- or halogenoalkyl-substituted cycloalkyl, or represents phenyl which is optionally mono- to pentasubstituted by alkylcarbonylamino, alkylcarbonylalkylamino and/or radicals from the list W.sup.3,R.sup.18 represents hydrogen, alkyl, alkenyl, halogenoalkyl, halogenoalkenyl, respectively optionally halogen-, alkyl- or halogenoalkyl-substituted cycloalkyl or cycloalkylalkyl or represents arylalkyl which is optionally mono to pentasubstituted by radicals from the list W.sup.3,R.sup.19 and R.sup.20 independently of one another each represent hydrogen, alkyl, alkenyl, halogenoalkyl, halogenoalkenyl, alkoxy, respectively optionally halogen-, alkyl- or halogenoalkyl-substituted cycloalkyl or cycloalkylalkyl, represent aryl or arylalkyl, each of which is optionally mono- to pentasubstituted by radicals from the list W.sup.3, represent --OR.sup.18 or --NR.sup.17 R.sup.18 or together represent an alkylene chain having 2 to 6 members in which one methylene group is optionally replaced by oxygen,R.sup.21 represents --OR.sup.18, --NR.sup.17 R.sup.19 or --N(R.sup.17)--COOR.sup.18,R.sup.22, R.sup.23 and R.sup.24 Independently of one another each represent alkyl,W.sup.1 represents hydrogen, halogen, cyano, formyl, nitro, alkyl, trialkylsilyl, alkoxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, alkylcarbonyl, alkoxycarbonyl, pentafluorothio or --S(O).sub.o R.sup.6,W.sup.2 represents halogen cyano, formyl, nitro, alkyl, trialkylsilyl, alkoxy, halogenoalkyl, halogenoalkoxy, alkylcarbonyl, alkoxycarbonyl, pentafluorothio or --S(O).sub.o R.sup.6 or --C(H.sup.17).dbd.N--R.sup.21,W.sup.3 represents halogen, cyano, nitro, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, dialkylamino --S(O).sub.o R.sup.6, --COOR.sup.26 or --CONR.sup.26 R.sup.27,R.sup.25 represents hydrogen, alkyl, halogenoalkyl, optionally halogen-, alkyl- or halogenoalkyl-substituted cycloalkyl or represents phenyl which is optionally mono- to pentasubstituted by radicals from the list W.sup.4,R.sup.26 and R.sup.27 independently of one another each represent hydrogen, alkyl, alkenyl, halogenoalkyl, halogenoalkenyl, alkoxy, respectively optionally halogen-, alkyl- or halogenoalkyl-substituted cycloalkyl or cycloalkylalkyl or represent aryl or arylalkyl, each of which is optionally mono- to pentasubstituted by radicals from the list W.sup.4, represent OR.sup.22 or --NR.sup.23 R.sup.24 or together represent an alkylene chain having 2 to 6 members in which one methylene group is optionally replaced by oxygen, andW.sup.4 represents halogen, cyano, nitro, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, dialkylamino, alkoxycarbonyl, dialkylaminocarbonyl or --S(O).sub.o R.sup.6 ;provided that if Y represents a direct bond, E cannot be hydrogen.