Patent ID: 6143791
Filing Date: 2000-11-07
Classification: A61K

Abstract:
A method for treating a disorder of the nervous system in which the pathophysiology of the disorder involves excessive or inappropriate release of a neurotransmitter from neuronal cells comprising administering to a mammal exhibiting symptoms of said disorder or susceptible to said disorder an effective amount of a compound of the following Formula III: ##STR16## wherein R and R.sup.1 are each independently substituted or unsubstituted alkyl having from 1 to about 20 carbon atoms, substituted or unsubstituted alkenyl having from 2 to about 20 carbon atoms, substituted or unsubstituted alkynyl having from 2 to about 20 carbon atoms, substituted or unsubstituted alkoxy having from 1 to about 20 carbon atoms, substituted or unsubstituted aryloxy having from 6 to about 20 carbon atoms, substituted or unsubstituted aralkoxy having from 6 to about 20 carbon atoms, substituted or unsubstituted carbocyclic aryl having at least 5 ring atoms, substituted or unsubstituted aralkyl having at least 5 ring atoms, or a substituted or unsubstituted heteroaromatic or heteroalicyclic group having 1 to 3 rings, 3 to 8 ring members in each ring and 1 to 3 heteroatoms,with at least one of R and R.sup.1 being substituted or unsubstituted aryloxy, substituted or unsubstituted aralkoxy, substituted or unsubstituted alkylsulfinyl or substituted or unsubstituted alkylsulfonyl;R.sup.2 and R.sup.3 each independently being hydrogen, substituted or unsubstituted alkyl having from 1 to about 20 carbon atoms, substituted or unsubstituted alkenyl having from 2 to about 20 carbon atoms, substituted or unsubstituted alkynyl having from 2 to about 20 carbon atoms, substituted or unsubstituted alkoxy having from 1 to about 20 carbon atoms, substituted or unsubstituted aryloxy having from 6 to about 20 carbon atoms; substituted or unsubstituted aralkoxy having from 6 to about 20 carbon atoms; substituted or unsubstituted aminoalkyl having 1 to about 20 carbon atoms; substituted or unsubstituted alkylthio having 1 to about 20 carbon atoms; substituted or unsubstituted alkylsulfinyl having 1 to about 20 carbon atoms; substituted or unsubstituted alkylsulfonyl having 1 to about 20 carbon atoms; substituted or unsubstituted carbocyclic aryl having at least 5 ring atoms, substituted or unsubstituted aralkyl having at least 5 ring atoms, or a substituted or unsubstituted heteroaromatic or heteroalicyclic group having 1 to 3 rings, 3 to 8 ring members in each ring and 1 to 3 heteroatoms;n and n' independently are each equal to 1, 2, or 3;X and X' are each independently a chemical bond, substituted or unsubstituted alkylene having 1 to about 8 carbon atoms, with at least one of X and X' being other than a chemical bond; and pharmaceutically acceptable salts thereof.