Patent ID: 6583136
Filing Date: 2003-06-24
Classification: A61P,C07D

Abstract:
A compound of formula a N-oxide form, a salt, a quaternary amine or stereochemically isomeric form thereof, whereinD represents a radical of formula wherein the dotted line represents the bond attaching D to the remainder of the compound of formula (I); X is N or CH; R3 is hydrogen or halo; R4 is halo; â€”Aâ€”Bâ€” represents a bivalent radical of formula: â€”N&boxH;CHâ€”â€ƒâ€ƒ(i), â€”CH&boxH;Nâ€”â€ƒâ€ƒ(ii), â€”CH&boxH;CHâ€”â€ƒâ€ƒ(iii), â€”CH2â€”CH2â€ƒâ€ƒ(iv), wherein one hydrogen atom in the radicals (i) and (ii) may be replaced by a C1-4alkyl radical and one or more hydrogen atoms in radicals (iii) and (iv) may be replaced by a C1-4alkyl radical; Alk represents C1-6alkanediyl; Y represents C1-6alkanediyl optionally substituted with one or two substituents selected from halo, hydroxy, mercapto, C1-4alkyloxy, C1-4alkylthio, aryloxy, arylthio, arylC1-4alkyloxy, arylC1-4alkylthio, cyano, amino, mono- or di(C1-4alkyl)amino, mono- or di(aryl)amino, mono- or di(arylC1-4alkyl)amino, C1-4alkyloxycarbonylamino, benzyloxycarbonylamino, aminocarbonyl, carboxyl, C1-4alkyloxycarbonyl, guanidinyl, and aryl; R1 represents hydrogen, C1-6alkyl or arylC1-6alkyl; R2 represents hydrogen, C1-6alkyl or arylC1-6alkyl; or R1 and R2 may be taken together to form a heterocyclic radical selected from morpholinyl, pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl or phthalimid-1-yl; said heterocyclic radical may optionally be substituted with C1-4alkyl, aryl, arylC1-4alkyl, hydroxyC1-4alkyl, amino, mono- or di(C1-4alkyl)amino, aminoC1-4alkyl, mono- or di(C1-4alkyl)aminoC1-4alkyl, carboxyl, aminocarbonyl, C1-4alkyloxycarbonyl, C1-4alkyloxycarbonylamino or mono- or di(C1-4alkyl)aminocarbonyl; aryl represents phenyl, naphthalenyl, 1,2,3,4-tetrahydro-naphthalenyl, indenyl or indanyl; each of said aryl groups may optionally be substituted with one or more substituents selected from halo, C1-4alkyl, hydroxy, C1-4alkyloxy, nitro, amino, trifluoromethyl, hydroxyC1-4alkyl, C1-4alkyloxyC1-4alkyl, aminoC1-4alkyl, mono- or di(C1-4alkyl)aminoC1-4alkyl.