Patent ID: 6303774
Filing Date: 2001-10-16
Classification: A61P,C07H

Abstract:
A compound having the structure of formula (I) ##STR35##wherein:x and y are integers in the range of 1 to 3 inclusive;n is 0, 1 or 2, wherein when n is 2, the two X moieties may be the same or different;Cat is a cationic species;R.sup.1 is a purine or pyrimidine base bound to a cyclic or acyclic sugar moiety, and may represent a single nucleoside or a nucleoside monomer contained within an oligonucleotide chain, wherein R.sup.1 is bound through either its 3' or 5' position;R.sup.2 is selected from the group consisting of N.sup.- --ClO.sub.3, N.sup.- --NO.sub.2 and N.sup.- --SO.sub.2 R.sup.3 wherein R.sup.3 is lower alkyl, halogenated lower alkyl, halo or amino;X is--X.sup.1 --X.sup.2 -- or --X.sup.3.dbd.N--;X.sup.1 and Y are independently selected from the group consisting of ##STR36##whereinZ.sup.1 is selected from the group consisting of O, S, C(CN).sub.2, NClO.sub.3, N--NO.sub.2, N--SO.sub.3 and N--SO.sub.2 R.sup.3, andZ.sup.2 is selected from the group consisting of O.sup.-, S.sup.-, lower alkyl, halogenated lower alky, halo, BH.sub.3.sup.-, N.sup.- --ClO.sub.3, N.sup.- --NO.sub.2 and N.sup.- --SO.sub.2 R.sup.3 [with the proviso that when R.sup.2 is N.sup.- --ClO.sub.3, then Y is other than ##STR37##X.sup.2 is selected from the group consisting of O, S and N.sup.- ; andX.sup.3 is ##STR38##whereinZ.sup.3 and Z.sup.4 are independently selected from the group consisting of O.sup.-, S.sup.-, lower alkyl, halogenated lower alkyl, halo, BH.sub.3.sup.-, N.sup.- --ClO.sub.3, N.sup.- --NO.sub.2 and N.sup.- --SO.sub.2 R.sup.3with the proviso that when R.sup.2 is N.sup.- --ClO.sub.3, then Y is other than ##STR39##