Patent ID: 8901278
Filing Date: 2014-12-02
Classification: A61K,A61P,C07K

Abstract:
1. A pharmaceutical composition comprising an IgG1 antibody specifically binding to human CEA, wherein said IgG1 antibody comprises heavy chain variable (V H ) domain and a light chain variable (V L ) domain, wherein the heavy chain variable domain comprises: (1) a CDR-H1 having the amino acid sequence “TYAMH” (SEQ ID NO. 31); (2) a CDR-H2 having the amino acid sequence “LISNDGSNKYYADSVKG” (SEQ ID NO. 30); and (3) a CDR-H3 having the amino acid sequence “DX1X2X3X4FYFDY” (SEQ ID NO. 99), wherein said X1 is F, M, E or T; X2 is Y, A, D or S; X3 is F, M E or T; and; X4 is Y, A, D or S; and further comprises light chain variable domain CDRs CDR-L1 having the amino acid sequence “TLRRGINVGAYSIY” (SEQ ID NO. 34) and a CDR-L2 having the amino acid sequence “YKSDSDKQQGS” (SEQ ID NO. 33) and a CDR-L3 having the amino acid sequence “MIWHSGASAV” (SEQ ID NO. 32).