Patent ID: 6395939
Filing Date: 2002-05-28
Classification: C07B,C07C

Abstract:
The method depicted in scheme 1: whereinAr and Arâ€² independently represent optionally substituted monocyclic or polycyclic aromatic or heteroaromatic moieties; X represents Br, I, â€”O3S(alkyl), or â€”O3S(aryl); Y represents O, S, Se, NR, PR, or AsR; Z represents H, a group that is lost under the reaction conditions to generate a negative charge on Y, or a group that is replaced by H under the reaction conditions; R represents H, alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, trialkylsilyl, acyl, or sulfonyl; catalyst is selected from the group consisting of copper carboxylates, copper carbonates, copper sulfates, copper sulfonates, copper halides, copper trifluoroborates, and copper phosphates; co-catalyst represents an uncharged molecule comprising a Lewis basic pair of electrons; alkali or alkaline earth salt represents a salt selected from the group consisting of cesium bicarbonate, cesium carbonate, cesium carboxylates, ccsium phosphates, cesiurn alkoxides, cesium silicates, cesium amides, and cesium sulfides; the reaction takes place at a temperature less than about 150Â° C.; and the method is not conducted in an amine solvent or an aqueous solvent.