Patent ID: 8357654
Filing Date: 2013-01-22
Classification: A61K,A61P,C07K

Abstract:
1. A compound corresponding to the following formula (I): wherein: Y represents a macrocycle functionalized by three amine or COOH functions, and corresponds to formula (II): j is 0 or 1; A represents an amino acid residue or an amino acid derivative selected from the group consisting of: n representing 0, 1, 2 or 3; p representing 0, 1, 2 or 3; and E representing NH or O; B n representing 0, 1, 2 or 3; p representing 0, 1, 2 or 3; E representing NH or O; and Ra representing a chain of a proteinogenic amino acid, C1-C8 alkylated; B n representing 0, 1, 2 or 3; p representing 0, 1, 2 or 3; E representing NH or O; Ra representing the chain of a proteinogenic amino acid, C1-C8 alkylated; D representing one of the following groups: (+)-Biotinyl-, (+)-Biotinyl-X q representing an integer varying from 2 to 6; and X R X R representing H, Me, Et, Pr or Bu; and cyclic dialkylated amino acids of the following formula: k representing 1, 2, 3 or 4; X X X X -L- represents a pseudopeptide-type bond between the X′ F X′ X′ R representing H, Me, Et, Pr or Bu; and cyclic dialkylated amino acids of the following formula: k representing 1, 2, 3 or 4.