Patent ID: 6297261
Filing Date: 2001-10-02
Classification: A61P,C07C

Abstract:
A compound having the formula ##STR7##or a pharmaceutically acceptable salt thereof;wherein one of R.sup.1, R.sup.2 and R.sup.3 is a heterocyclic acidic functional group having a pKa value below 8;R.sup.4, R.sup.5 and a remaining two of the three substituents R.sup.1, R .sup.2 and R.sup.3 are each independently selected from the group consisting of hydrogen; alkyl; alkoxy; hydroxy; halogen; trifluoromethyl; cyano; nitro; amino; alkylamino; --COOR.sup.7 ; --NHSO.sub.2 --alkyl; --SO.sub.2 N(R.sup.7).sub.2 ; --SO.sub.2 OR.sup.7 ; --CO--R.sup.7 ; aryl, biphenyl, phenylamino, phenoxy or heteroaryl;wherein the aryl, biphenyl, phenylamino, phenoxy or heteroaryl group may be substituted one or more times with substituents selected from the group consisting of alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, nitro, amino and alkylamino; aryl and heteroaryl,or R.sup.3 and R.sup.4 or R.sup.4 and R.sup.5 together form a cyclic structure and a remaining three of the five substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined above;R.sup.7 is hydrogen, alkyl, amino or phenyl;Y is --CO--;X is --NH--, --CH.sub.2 --NH--, or --SO.sub.2 --NH--;Z is NR.sup.6, wherein R.sup.6 is hydrogen, or alkyl; R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 are each independently selected from the group consisting of hydrogen; alkyl; alkoxy; hydroxy; halogen; trifluoromethyl; cyano; nitro; amino; alkylamino; --COOR.sup.7 ; --NHSO.sub.2 -alkyl; --SO.sub.2 N(R.sup.7).sub.2 ; --SO.sub.2 OR.sup.7 ; --CO--R.sup.7 ; aryl, biphenyl, phenylamino, phenoxy or heteroaryl;wherein the aryl, biphenyl, phenylamino, phenoxy or heteroaryl group may be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, nitro, amino and alkylamino; aryl and heteroaryl;or one of R.sup.11 and R.sup.12, R.sup.12 and R.sup.13, R.sup.13 and R.sup.14 and R.sup.14 and R.sup.15 together form a cyclic structure, substituents R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 is as defined above and R.sup.7 is as defined abovewith the proviso that the compound is not:N-[3-(2,5-dihydro-5-thioxo-1H-tetrazol-1-yl)phenyl]-N'-[4-[5-[2-(hydroxymet hyl)phenyl]-2-oxo-1,3,4-oxadiazol-3(2H) -yl]phenyl]-urea; or N-[3-2,5-dihydro-5-thioxo-1H-tetrazol -l-yl)phenyl]-N'-[4-(2-oxo-1, 3, 4-oxadiazol-3(2H)-yl)phenyl]-urea.