Patent ID: 7626011
Filing Date: 2009-12-01
Classification: A61K,C07K

Abstract:
1. An isolated nucleic acid sequence encoding an antibody specific to carcinoembryonic antigen (CEA) with a dissociation constant of less than 5.0 nM for said CEA antigen and comprising the following six CDRs: (a) Heavy Chain CDR 1: gly phe asn ile lys asp ser (from 55 to 61 of SEQ ID NO:6); (b) Heavy Chain CDR 2: asp pro glu asn gly asp (from 81 to 86 of SEQ ID NO:6); (c) Heavy Chain CDR 3: thr pro thr gly pro tyr tyr phe asp (from 129 to 137 of SEQ ID NO:6); (d) Light Chain CDR 1: (i) ser ser ser val pro (from 190 to 194 of SEQ ID NO:6), or (e) Light Chain CDR 2: leu thr ser (from 213 to 215 of SEQ ID NO:6); (f) Light Chain CDR 3: arg ser ser tyr pro leu (from 254 to 259 of SEQ ID NO:6).