Patent ID: 8765727
Filing Date: 2014-07-01
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or pharmaceutically acceptable salt thereof or quaternary ammonium salt thereof, wherein: X X X A B D L wherein at least one of L R′ and R″ are each, independently, selected from H, halo, C or R′ and R″ together with the C atom to which they are attached form a 3-, 4-, 5-, 6-, 7-, 8-, 9- or 10-membered cycloalkyl group or heterocycloalkyl group, each optionally substituted with 1, 2, or 3 substituents independently selected from halo, C R each R each R R R each R R W each W Q Y Z Cy Cy L R or R each R e1 is, independently, H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, (C 1-6 alkoxy)-C 1-6 alkyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocycloalkylalkyl; each R f1 is, independently, H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl; R or R each R each R R or R R R each p1 is, independently, 0, 1, or 2; each p2 is, independently, 0, 1, or 2; each p3 is, independently, 0, 1, or 2; each p4 is, independently, 0, 1, or 2; each q1 is, independently, 1 or 2; each q2 is, independently, 1 or 2; each n is, independently, 1, 2, or 3; each m is, independently, 0, 1, or 2; and t is 1, 2, 3, or 4.