Patent ID: 6084065
Filing Date: 2000-07-04
Classification: A01N,C07C,C07K

Abstract:
An oligopeptide compound having the formula (I):K--(--A--).sub.z --(--B--).sub.w --L (I)wherein:z and w are the same or different from each other and are 1 or 2;A represents an aminoacidic radical having the formula (II): ##STR16## wherein: R.sub.a represents a linear or branched C.sub.3 -C.sub.4 alkyl radical or a C.sub.3 -C.sub.4 cycloalkyl radical;R' represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl radical;B represents an aminoacidic radical having the formula (III): ##STR17## wherein: R.sub.b represents an unsubstituted phenyl radical, an unsubstituted naphthyl radical or a substituted phenyl radical or a substituted naphthyl radical which is substituted with one or more halogen atoms, which are the same or different from each other, and are selected from the group consisting of fluorine, chlorine, bromine and iodine, or with one or more groups, which are the same or different from each other, and are selected from the group consisting of linear or branched C.sub.1 -C.sub.5 alkyl or haloalkyl radicals, linear or branched C.sub.1 -C.sub.5 alkoxy, haloalkoxy radicals, C.sub.3 -C.sub.6 cycloalkyl or cycloalkoxy radicals, C.sub.2 -C.sub.5 carbalkoxy radicals, cyano radicals and methylene dioxyl radicals having the formula (VI): ##STR18## wherein: R.sup.7 and R.sup.8, which are the same or different from each other, and represent a hydrogen atom, a fluorine atom, a C.sub.1 -C.sub.3 alkyl or haloalkyl radicals;m is 1 and n is 0 or 1;R"" represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl radical;L represents a moiety having the formula (IV): ##STR19## wherein: E represents a linear or branched C.sub.1 -C.sub.8 alkylene or haloalkylene chain, an omega-oxa-C.sub.2 -C.sub.8 alkyl chain or a direct linkage;R.sup.1 represents a hydrogen atom, a C.sub.3 -C.sub.6 cycloalkyl radical or an unsubstituted or substituted phenyl radical;R.sup.2 represents a hydrogen atom, a linear or branched C.sub.2 -C.sub.6 carbamoyl radical, a cyano radical or a halogen atom selected from the group consisting of fluorine, chlorine and bromine;X represents an --O-moiety; a --N(R.sup.3)-- moiety or a --N(R.sup.4)--O-moiety,wherein:R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl or alkoxy radical, or R.sup.3 together with R.sup.1, represents a direct linkage or a C.sub.2 -C.sub.4 alkylene chain;R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl radical, or R.sup.4 together with R.sup.1, represents a direct linkage or a C.sub.2 -C.sub.4 alkylene chain;with the proviso that when X represents an --O-- moiety, and E represents a direct linkage, only one of R.sup.1 and R.sup.2 is present;K represents a linear or branched C.sub.1 -C.sub.4 alkyl radical or a protective group having the formula (V): ##STR20## wherein: Y represents an oxygen atom or a direct linkage;M represents a linear, branched or cyclic C.sub.1 -C.sub.8 alkylene or a haloalkylene chain or a direct linkage;R.sup.5 represents a hydrogen atom, a substituted or unsubstituted phenyl radical or an unsubstituted or substituted phenoxy radical;R.sup.6 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkoxy or haloalkoxy radical, an acetate radical, an acetamidic radical or a halogen atom selected from the group consisting of fluorine, chlorine and bromine,with the proviso that when Y represents an oxygen atom, and M represents a direct linkage, only one of R.sup.5 and R.sup.6 is present.