Patent ID: 6777409
Filing Date: 2004-08-17
Classification: A61K,A61P,C07D

Abstract:
A method for treating inflammation in a patient comprising administering a therapeutically effective amount of a compound of formula I or a physiologically compatible salt thereof to said patient in whichR1 and R2 are the same or different and stand for a hydrogen atom, a C1-C5 alkyl group, or, together with the C-atom of the chain, stand for a ring with a total of 3-7 links, R3 stands for a straight-chain or branched C1-C5 alkyl group or a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group, A stands for the group â€ƒ(the dashed line means the interface site), in which R4 to R8 are the same or different from one another and mean a hydrogen atom, a halogen atom, a cyano group, a nitro group, a COOR9 group whereby R9 stands for a hydrogen atom, a straight-chain or branched C1-C5 alkyl group or a benzyl group, a CONR10 group, whereby R10 stands for a hydrogen atom or a straight-chain or branched C1-C5 alkyl group, an NHR11 group, whereby R11 stands for a hydrogen atom, a straight-chain or branched C1-C5 alkyl group, a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group, a C1-C5 acyl group, an â€”SO2â€”(C1-C5) alkyl group or an â€”SO2-phenyl group that is optionally substituted by halogen or a C1-C5 alkyl group, a straight-chain or branched C1-C5 alkyl group, a straight-chain or branched C2-C5 alkenyl group, a straight-chain or branched C2-C5 alkinyl group, a straight-chain or branched C1-C5 alkyl group that is partially or completely substituted by fluorine atoms, a C1-C5 acyl group, an aryl radical or a heteroaryl radical, or R4 and R5 together with the two carbon atoms of ring A mean a saturated or unsaturated carbocyclic ring with a total of 5-7 links, Ar stands for a ring system, selected from the group of general partial formula 1 or 2, in whichradicals X3a, X3b, X4, X6, X7 (in partial formula 1) and Y4, Y5, Y7, and Y8 (in partial formula 2) are the same or different and mean a hydrogen atom, a straight-chain or branched C1-C5 alkyl group, or a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group, radicals X4, X6, X7 (in partial formula 1) or Y5, Y7, Y8 (in partial formula 2) in addition are the same or different and mean a hydrogen atom, a halogen atom, a hydroxy group, a C1-C5 alkoxy group or a C1-C5 alkanoyloxy group, as well as their racemates or separately present stereoisomers.