Patent ID: 8039624
Filing Date: 2011-10-18
Classification: A61P,C07D

Abstract:
1. A compound of the general formula (I) wherein U is CH U is C═O, and V is NR one of the variables W, X, Y and Z are nitrogen, the remaining variables being CR 8 ; R 1 is H, C C C —(CR —(CR —S(O) —S(O) —S(O) —S(O) A is halo, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -hydroxyalkyl, C 1-6 -cyanoalkyl, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —S(O) 0-2 C 1-6 -alkyl, nitro, hydroxy, cyano, —(C 1-6 -alkylene)-O—C 1-6 -alkyl, —(C 1-6 -alkylene)-O—C 1-6 -haloalkyl, —(C 1-6 -alkylene)-OR′″, —C(O)OC 1-6 -alkyl, —C(O)C 1-6 -alkyl, —C(O)OR′″, —C(O)R′″, —C(O)NR′R″, —S(O) 2 NR′R″, —(CH 2 ) x —NR′R″, —(CH 2 ) x —NR′C(O)—C 1-6 -alkyl, —(CH 2 ) x —NR′S(O) 2 —C 1-6 -alkyl, —(CH 2 ) x —C 3-6 -cycloalkyl, —(CH 2 ) x —R′″, wherein x is from 0 to 4, R′ and R″ are each independently H or C R′ and R″ together with the nitrogen to which they are bound form a 5 or 6-membered heterocycle comprising one or two heteroatoms selected from N, O and S, and R″′ is phenyl or 5- to 6-membered heteroaryl, optionally substituted with one, two, or three halo, C R 2 is hydrogen, C —C(O)R R 3 , R 4 , R 5 , R 6 are each independently hydrogen, halo, C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy or halo-C 1-6 -alkoxy; or R 1 and R 6 together with the indole ring to which they are attached form a 6 membered heterocycle which is optionally substituted with residues selected from ═O, C(O)O—C 1-6 -alkyl and C 1-6 -alkyl; R 7 is hydrogen or C 1-6 -alkyl; R 8 is hydrogen, halo, methyl, methoxy, CF 3 , or OCF 3 ; wherein 5- to 6-membered heteroaryl is selected from the group consisting of pyrrolyl, pyrazolyl, imidazolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, and pyridazinyl; and 3- to 7-membered heterocycloalkyl is selected from the group consisting of oxiranyl, thiiranyl, aziridinyl, oxetanyl, azetidinyl, tetrahydro-furanyl, tetrahydro-thiophenyl, pyrrolidinyl, pyrazolidinyl, imidazolidinyl, oxazidinyl, isoxazidinyl, thiazolidinyl, isothiazolidinyl, piperidinyl, piperazidinyl, morpholinyl, and tetrahydropyranyl; or a pharmaceutically acceptable salt thereof.