Patent ID: 7201892
Filing Date: 2007-04-10
Classification: A61K,A61P,C07D,C09B

Abstract:
1. A compound of formula 2 wherein W 1 and W 2 are O; Y 1 , Y 2 , Z 1 , and Z 2 are independently selected from the group consisting of hydrogen, tumor-specific agent, phototherapy agent, —CONH-Bm, —NHCO-Bm, —(CH 2 ) a —CONH-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 –CONH-Bm, —(CH 2 ) a —NHCO-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO-Bm, —(CH 2 ) a —N(R 12 )—(CH 2 ) b —CONH-Bm, —(CH 2 ) 2 —N(R 12 )—(CH 2 ) c —NHCO-Bm, —(CH 2 ) a —N(R 12 )—CH 2 —(CH 2 —OCH 2 ) b —CH 2 CONH-Bm, —(CH 2 ) a —N(R 12 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—(CH 2 ) a —CONH-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—(CH 2 ) a —NHCO-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—CH 2 —(CH 2 OCH 2 ) d —CONH-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—CH 2 —(CH 2 OCH 2 ) d —NHCO-Bm, —CONH-Dm, —NHCO-Dm, —(CH 2 ) a —CONH-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH-Dm, —(CH 2 ) a —NHCO-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO-Dm, —(CH 2 ) a —N(R 12 )—(CH 2 ) b —CONH-Dm, —(CH 2 ) a —N(R 12 )—(CH 2 ) c —NHCO-Dm, —(CH 2 ) a —N(R 12 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH-Dm, —(CH 2 ) a —N(R 12 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )–(CH 2 ) a —CONH-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—(CH 2 ) a —NHCO-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—CH 2 —(CH 2 OCH 2 ) d —CONH-Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 12 )—CH 2 —(CH 2 OCH 2 ) d —NHCO-Dm, —(CH 2 ) a —N R 12 R 13 and —CH 2 (CH 2 OCH 2 ) b —CH 2 N R 12 R 13 K 1 and K 2 are independently selected from the group consisting of C 5 –C 30 aryl, C 1 –C 30 alkoxyl, C 1 –C 30 polyalkoxyalkyl, C 1 –C 30 polyhydroxyalkyl, C 5 – 30 polyhydroxyaryl, C 1 –C 30 aminoalkyl, saccharide, peptide, —CH 2 (CH 2 OCH 2 ) b —CH 2 —, —(CH 2 ) a –CO—, —(CH 2 ) a —CONH, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—, —(CH 2 ) a —NHCO—, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—, —(CH 2 ) a —O—, and —CH 2 —(CH 2 OCH 2 ) b —CO—; X 1 and X 2 are single bonds, or are independently selected from the group consisting of nitrogen, saccharide, —CR 14 —, —CR 14 R 15 , —NR 16 R 17 , and C 5 –C 30 aryl; Q is a single bond or is selected from the group consisting of —O—, —S—, —Se—, and —NR 18 ; a 1 and b 1 independently vary from 0 to 5; R 12 , R 13 , and R 18 to R 31 are independently selected from the group consisting of hydrogen, C 1 –C 10 alkyl, C 5 –C 20 aryl, C 1 –C 10 alkoxyl, C 1 –C 10 polyalkoxyalkyl, C 1 –C 20 polyhydroxyalkyl, C 5 –C 20 polyhydroxyaryl, C 1 –C 10 aminoalkyl, cyano, nitro, halogen, saccharide, peptide, —CH 2 (CH 2 OCH 2 ) b —CH 2 —OH, —(CH 2 ) a —CO 2 H, —(CH 2 ) a —CONH-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH-Bm, —(CH 2 ) a —NHCO-Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO-Bm, —(CH 2 ) a —OH and —CH 2 —(CH 2 OCH 2 ) b —CO 2 H; R 14 to R 17 are independently selected from the group consisting of hydrogen, C 1 –C 10 alkyl, C 5 –C 20 aryl, C 1 –C 10 alkoxyl, C 1 –C 10 polyalkoxyalkyl, C 1 –C 20 polyhydroxyalkyl, C 5 –C 20 polyhydroxyaryl, C 1 –C 10 aminoalkyl, saccharide, peptide, —CH 2 (CH 2 OCH 2 ) b —CH 2 —, —(CH 2 ) a —CO—, —(CH 2 ) a —CONH—, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—, —(CH 2 ) a —NHCO—, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—, —(CH 2 ) a —O—, and —CH 2 —(CH 2 OCH 2 ) b —CO—; Bm and Dm are independently selected from the group consisting of bioactive peptide, protein, cell, antibody, antibody fragment, saccharide, glycopeptide, peptidomimetic, drug, drug mimic, hormone, metal chelating agent, radioactive or nonradioactive metal complex, echogenic agent, photoactive molecule, and phototherapy agent; a and c independently vary from 1 to 20; b and d independently vary from 1 to 100.