Patent ID: 8603529
Filing Date: 2013-12-10
Classification: A61K,A61P,C12N

Abstract:
1. A cross-linked material comprising: (a) multivalent polynucleotide aptamers that bind glucose, wherein the multivalent aptamers comprise (i) at least 40 contiguous nucleotides that are 90% identical to nucleotides 20-59 of SEQ ID NO: 2, 3, 5, or 7; (ii) nucleotides 20-59 of SEQ ID NO: 4 or 6; or (iii) nucleotides 20-45 of SEQ ID NO: 1; and (b) conjugates that include two or more separate affinity ligands bound to a conjugate framework, and wherein the two or more affinity ligands compete with a target molecule for binding with the aptamers and wherein the conjugates are cross-linked within the material as a result of non-covalent interactions between aptamers and affinity ligands on different conjugates.