Patent ID: 6835735
Filing Date: 2004-12-28
Classification: A61P,C07D

Abstract:
A compound that has Formula I: or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein: n is 1, 2 or 3; R1 is substituent group, may be identical or different when n is 2 or 3, and is selected from the group consisting of hydrogen, halogen, C1-6-alkyl, C3-6-cycloalkyl, hydroxy, C1-6-alkoxy, C3-6-cycloalkoxy, (aryl or heteroaryl)oxy, C1-6-thioalkoxy, C3-6-thiocycloalkoxy, thio(aryl or heteroaryl)oxy, nitro, amino, N-mono(C1-6)-alkylamino, N,N-di(C1-6)-alkylamino, formamido, amido, acetamido, hydroxyamino, C1-6-alkoxyamino, hydrazino, trifluoromethyl, trifluoromethoxy, alkenyl, alkynyl, aryl and heterocyclic; and R2 and R3 are substituent groups of â€”(CH2)mâ€”R4 and may be identical or different, wherein: m is 0 or 1, and R4 is selected from the group consisting of hydrogen, halogen, C1-6-alkyl, C3-6-cycloalkyl, hydroxy, C1-6-alkoxy, C3-6-cycloalkoxy, C1-6-thioalkoxy, C3-6-thiocycloalkoxy, amino, mono-(C1-6)-alkylamino, di-(C1-6)-alkylamino, formamido, nitro, hydroxyamino, C1-6-alkoxyamino, hydrazino, cyano, carboxyl, alkoxycarbonyl, amido, N-mono-(C1-6)-alkylamido, N,N-di-(C1-6)-alkylamido, thioamido, N-mono-(C1-6)-alkylthioamido, N,N-di-(C1-6)-alkylthioamido, guanidino, ureido, C1-6-alkylsulfido, C1-6-alkylsulfonyl, trifluoromethyl, trifluoromethoxy, morpholino, 4-C1-6-alkylpiperidino, mono[hydroxy(C1-6)-alkyl]amino, di[hydroxy-(C1-6)-alkyl]amino, mono[pyrrolidine-(C1-6)-alkyl]amino, and di[pyrrolidine-(C1-6)-alkyl]amino or â€”N(R5)(CHR6R7), wherein R5 is hydrogen or C1-6-alkyl, R6 is (CH2)nOH where n is an integer of 1 to 4, and R7 is selected from the group consisting of hydrogen, C1-5-alkyl, hydroxy-(C1-5)-alkyl, thiohydroxy-(C1-5)-alkyl, phenyl-(C1-5)-alkyl, 4-hydroxyphenyl-(C1-5)-alkyl and heteroaryl-(C1-5)-alkyl, wherein at least one of R2 and R3 is other than hydrogen.