Patent ID: 6770642
Filing Date: 2004-08-03
Classification: A61P,C07D

Abstract:
A compound of formula I whereinQ is SO2, CO, CONR9 or CSNR10; n is an integer of 2 or 3; R1 and R2 are each independently H, halogen, CN, OCO2R12, CO2R13, CONR14R15, CNR16NR17R18, SOmR19, NR20R21, OR22, COR23 or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R3 and R4 are each independently H or an optionally substituted C1-C6alkyl group; R5 and R6 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted, or R5 and R6 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom selected from O, N or S; R7 is H, halogen, or a C1-C6alkyl, C1-C6alkoxy, aryl or heteroaryl group each optionally substituted; R8 is an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S; m is 0 or an integer of 1 or 2; R9 and R10 are each independently H or a C1-C6alkyl, aryl or heteroaryl group each optionally substituted; R12, R13, R19 and R23 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R14, R15 and R22 are each independently H or an optionally substituted C1-C6alkyl group; and R16, R17, R18, R20 and R21 are each independently H or an optionally substituted C1-C4alkyl group; or R20 and R21 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, N or S; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.