Patent ID: 6787556
Filing Date: 2004-09-07
Classification: A61K,A61P,C07D

Abstract:
A method for treatment of type 2 diabetes, treatment of insulin resistance syndrome (IRS), treatment of dyslipidemia or reducing the risk of cardiovascular disease comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, optionally in combination with a pharmaceutically acceptable excipient, where Q, X, Y and Z are either â€”CRa&boxH;, â€”CRb&boxH;CRcâ€” or â€”N&boxH;; where Ra, Rb and Rc are independently selected from hydrogen, halo or a bond, such that together with the nitrogen atom to which Y and Z are attached, they form a five- or six-membered aromatic ring;R1 and R3 are independently selected from C1-3alkyl, halo, haloC1-3alkyl, C1-3alkoxy, or haloC1-3alkoxy; n and m are independently selected from 0, 1 or 2; A is an alkylene, alkenylene or alkynylene chain optionally interposed by a heteroatom; and R2 is an optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted cycloalkyl moiety.