Patent ID: 8962596
Filing Date: 2015-02-24
Classification: A61P,C07D

Abstract:
1. A compound of the general Formula I and stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein: X R R hetAr hetCyc hetAr hetAr hetAr hetCyc Ar hetCyc hetCyc hetAr Ar R R hetAr R R R R or R or R or R or R or R hetCyc Ar hetAr hetCyc R′ and R″ are independently hydrogen or methyl, or R′ and R″ together with the carbon atom to which they are attached form a cyclopropylidine ring; hetAr Rc is (1-6C)alkyl, fluoro (1-3C)alkyl, difluoro(1-3C)alkyl trifluoro (1-3C)alkyl, tetrafluoro(1-3C)alkyl, pentafluro(1-3C)alkyl, (3-6C)cycloalkyl (optionally substituted with (1-6C)alkyl), or phenyl (optionally substituted with one or more groups independently selected from (1-6C alkyl), CF R R