Patent ID: 7399463
Filing Date: 2008-07-15
Classification: A61K,A61P

Abstract:
1. A stabilized HSA-free pharmaceutical composition comprising substantially monomeric interferon-beta (IFN-β) or biologically active variant thereof solubilized in a low-ionic-strength formulation, wherein said low-ionic-strength formulation is a solution that comprises a buffer at a concentration of about 2 mM to about 7 mM, said composition having a pH within plus or minus 0.5 units of a specified pH, where the specified pH is about 3.0 to about 5.0, said formulation having an ionic strength that is not greater than about 20 mM, and wherein said composition further comprises trehalose; said biologically active variant of IFN-β having the ability to bind to IFN-β receptors.