Patent ID: 6541482
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A compound of the formula whereinX is N3, NH2, NHR, N(R)2, CN, SH, SR or OR1; R is C1-C4 alkyl or (CH2)nâ€”&phgr;; n is an integer 0, 1, 2, 3 or 4;&phgr; is a phenyl group unsubstituted or substituted with from 1 to 3 substituents, each substituent is independently selected from the group consisting of C1-C4 alkyl, C1-C4 alkoxy, halogen, CF3, OCF3, OH, CN, NO2 or NH2; R1 is C1-C4 alkyl or (CH2)mâ€”NR2R3; m is an integer 1, 2, 3 or4; R2 and R3 are each independently C1-C4 alkyl, C1-C4 fluorinated alkyl or cycloalkyl; The X substituent on the cyclopencanyl ring is in the TRANS configuration relative to the bicyclic substituent; Y is nitrogen; Z1 and Z2 are each independently hydrogen, halogen or NH2; and ---- represents a single or double bond; or a pharmaceutically acceptable salt thereof.