Patent ID: 8129533
Filing Date: 2012-03-06
Classification: A61K,A61P

Abstract:
1. A method for producing a lyophilized preparation containing, as an active ingredient, a compound represented by the following formula (1): wherein R A and A wherein X X Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, a C1-C6 alkyl group, a C2-C7 alkoxymethyl group, or a phenylalkyl group consisting of a C1-C6 alkylene group and a phenyl group, Z represents a mono-, di-, or tricyclic heterocyclic substituent, wherein the heterocyclic substituent may be saturated or partially saturated and may contain one or more hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, or the heterocyclic substituent may have a bicyclo structure or a spirocyclic structure and may be substituted by one or more atoms or groups selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a carbamoyl group, a C1-C6 alkyl group, a C1-C6 halogenoalkyl group, an aryl group, a heteroaryl group, a C1-C6 alkoxy group, a C1-C6 alkylamino group, a C1-C6 alkylthio group, and a C1-C6 aminoalkyl group,