Patent ID: 6762195
Filing Date: 2004-07-13
Classification: A61P,C07D

Abstract:
A substantially diastereomerically and enantiomerically pure compound selected from the group consisting of (a) an isolindoline of the formula: wherein:the carbon atoms designated * constitute centers of chirality; X is â€”C(O)â€” or â€”CH2â€”; R1 is alkyl of 1 to 8 carbon atoms or â€”NHR3; R2 is hydrogen, alkyl of 1 to 8 carbon atoms, or halogeno; and R3 is hydrogen, alkyl of 1 to 8 carbon atoms, unsubstituted or substituted with alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms, cycloalkyl of 3 to 18 carbon atoms, phenyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms, benzyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms, or â€”COR4 in which R4 is hydrogen, alkyl of 1 to 8 carbon atoms, unsubstituted or substituted with alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms, cycloalkyl of 3 to 18 carbon atoms, phenyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms, or benzyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbon atoms; and, (b) the acid addition salts of said isoindoline which are susceptible of protonation.