Patent ID: 6670363
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A compound of Formula IA and its pharmaceutically acceptable salts, enantiomers, diastereomers, N-oxides, whereinX is selected from the group consisting of CH2, CO, CS, SO2 and â€”N&boxH;Nâ€”, R is selected from the group consisting of (1) C1-C4 alkyl which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C1-C4 alkoxy and amino (2) C1-C4 alkoxy, (3) halogen (4) formyl (5) carboxyl (6) C1-C4 acyloxy (7) phenyl or substituted phenyl (8) hydroxy (9) nitro (10) amino (11) furyl (12) triazolyl (13) thienyl (14) piperazinyl (15) morpholinyl (16) thiomorpholinyl (17) imidazolyl (18) oxazolyl and (19) triazolone-yl; R1 and R2 are each independently selected from the group consisting of (1) hydrogen, (2) C1-C4 alkyl group which is unsubstituted or substituted with 1-3 substituents each independently selected from the group consisting of halogen, hydroxy, C1-C4 alkoxy and amino (3) nitro (4) amino (5) cyano (6) carboxyl (7) SO2Râ€² wherein Râ€² is hydrogen, alkyl or aryl and (8) C1-C4 alkoxy; Y is a phenyl group which is unsubstituted or substituted with substituents each independently selected from the group consisting of (1) halogen (2) nitro (3) amino (4) cyano (5) carboxyl (6) hydroxy (7) C1-C4 alkoxy and (8) SO2Râ€² wherein Râ€² is hydrogen, alkyl or aryl; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl group, halogen, hydroxy, C1-C4 alkoxy, nitro, amino, cyano, carboxyl and SO2Râ€² wherein Râ€² is hydrogen, alkyl or aryl; X1, X2, Y1, Y2 and Z are independently selected from the group consisting of hydrogen, halogen, nitro, cyano, amino, sulphonyl, aryl or substituted aryl, C1-C4 alkyl, C1-C4 alkoxy, and carboxyl, with the proviso that when X1, X2, Y1, and Y2 are all hydrogen, Z is not C1-C4 alkoxy.