Patent ID: 7741099
Filing Date: 2010-06-22
Classification: A61K,C07K,C12N

Abstract:
1. A batch of recombinant replication-defective adenovirus based upon adenovirus serotype 5 (Ad5), the recombinant replication-defective adenovirus comprising a chimeric hexon protein, wherein in the chimeric hexon protein hypervariable region sequences HVR1 to HVR7 of Ad5 have been replaced with those of Ad48 or of Pan9, in the following manner: the HVR1 sequence of Ad5 (SEQ ID NO: 17) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 24, and 52, the HVR2 sequence of Ad5 (SEQ ID NO: 18) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 25, and 53, the HVR3 sequence of Ad5 (SEQ ID NO: 19) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 26, and 54, the HVR4 sequence of Ad5 (SEQ ID NO: 20) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 27, and 55, the HVR5 sequence of Ad5 (SEQ ID NO: 21) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 28, and 56, the HVR6 sequence of Ad5 (SEQ ID NO: 22) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 29, and 57, and the HVR7 sequence of Ad5 (SEQ ID NO: 23) has been replaced by a sequence selected from the group consisting of SEQ ID NO: 30, and 58, and wherein the sequences between the HVR sequences are from Ad5.