Patent ID: 6316689
Filing Date: 2001-11-13
Classification: A01K,C12N

Abstract:
A rat comprising a rat 25 hydroxyvitamin D.sub.3 24-hydroxylase transgene which over-expresses said 25 hydroxyvitamin D.sub.3 24-hydroxylase transgene and exhibits a phenotype, resulting from said over-expression, selected from the group consisting of:(1) increased blood total cholesterol level,(2) increased blood triglyceride level,(3) increased urinary albumin concentration,(4) lower bone-salt density,(5) lower bone-mineral density(6) glomeruloscrelosis,(7) nephropathy,(8) simple hyperplasia of the renal ureter,(9) basophilic degeneration of renal tubular epithelium,(10) hyaline casts in the kidney,(11) dilatation of renal tubules,(12) small round cell infiltration in the kidney,(13) thickening of the tunicae media and externa of the small and medium arteries of the lung,(14) alveolar histicytosis,(15) ossification in the lung,(16) calcification of pulmonary arteries in the lung,(17) localized thickening of alveolar septa in the lung,(18) hemopoiesis, and(19) arterial hypertrophy in the spleen.