Patent ID: 8362068
Filing Date: 2013-01-29
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A compound of Formula IIIB: or a single enantiomer, a racemic mixture, a mixture of diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or prodrug thereof; wherein: U U V R each R each R two R L a bond, and the zigzag line on each moiety represents the point of attachment through which the moiety is connected to and wherein T 3 is a bond, C, N, O, S, CR 3a , or NR 3a ; U 3 , V 3 , W 3 , and X 3 are each independently C, N, O, S, CR 3a , or NR 3a ; and Y 3 is C or N; Z each R n is an integer of 2, 3, 4, 5, 6, or 7; p is an integer of 0, 1, 2, 3, 4, 5, 6, or 7; q and r are each independently an integer of 1, 2, 3, or 4; and s, t, and u are each an integer of 1; and wherein each alkyl, alkylene, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, and heterocyclyl is optionally substituted with one or more substituents Q, where each Q is independently selected from (a) cyano, halo, and nitro; (b) C wherein each Q