Patent ID: 6245888
Filing Date: 2001-06-12
Classification: A61P,C07K

Abstract:
A substantially pure protein p100 having a molecular weight of about 100 kDa as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) under reducing conditions, wherein said p100 comprises one or more of the following amino acid sequences:(i) NISFGRDQDNK (SEQ ID NO:1),(ii) HAIPNLV (SEQ ID NO:2),(iii) XVLINK (SEQ ID NO:3),(iv) XPIEDPANDTVDFPX (SEQ ID NO:4), and(v) XPSGALRNLAVDARX (SEQ ID NO:5),wherein the letters used are based on the standard single letter amino acid code, and wherein ""X"" designates any amino acid;wherein said protein is associated in vivo with the catenin-cadherin complex of epithelial or endothelial cells;wherein said protein has cross-reactivity with an antibody to p120; andwherein said protein is not recognized by antibody rr1;with the proviso that said protein is not p120.