Patent ID: 7585835
Filing Date: 2009-09-08
Classification: A61K,A61P,Y10S

Abstract:
1. A method of increasing muscle mass or muscle strength in a mammal in need thereof, comprising: administering a therapeutically effective amount of GASP1 to a mammal, wherein the GASP1 comprises the amino acid sequence encoded by a nucleic acid sequence chosen from: i) nucleotides 520-717 of SEQ ID NO:4; ii) nucleotides 328-525 of SEQ ID NO:6; iii) SEQ ID NO:4; iv) SEQ ID NO:6; and v) a nucleotide sequence that is at least 95% identical to (i), (ii), (iii), or (iv) and encodes a polypeptide having GDF-8 binding activity, thereby increasing muscle mass or muscle strength.