Patent ID: 8961445
Filing Date: 2015-02-24
Classification: A61M,B01D,B04B,Y10T

Abstract:
1. An apparatus to prepare concentrated blood components comprising: a) a container comprising blood, which blood comprises blood components, which blood components comprise one or more high density components, one or more intermediate density components, and/or one or more low density components, which blood components further comprise low molecular weight molecules and high molecular weight molecules; b) a separation disc comprising a first port in fluid communication with the container through a first conduit, the separation disc comprising a second port proximate to a separation disc axis of rotation, which separation disc is rotatably mounted to the apparatus; c) a pump operably coupled to the first conduit; d) a concentrator in fluid communication with the second port of the separation disc through a second conduit, which concentrator comprises one or more ultrafiltration membranes, which membranes comprise retentate sides and permeate sides; e) a valve operably coupled to the second conduit, which valve is configured to control transfer of blood components through the second conduit; f) a control system operably connected to the valve, and which control system is operably connected to the pump, whereby the control system is configured to control transfer of the blood between the container, the separation disc, and the concentrator; g) a first detector operably connected to the control system and mounted on the apparatus in operative orientation to the separation disc, configured to detect a fill level in the separation disc; and h) a second red blood cell (RBC) detector operably connected to the control system and mounted in operative orientation to the second conduit; whereby, the control system is configured to direct transfer of blood from the container to the separation disc; such that the separation disc rotates, thereby creating a centripetal force; wherein the centripetal force separates blood components in order of density, thereby accumulating one or more high density components at a periphery of the separation disc and accumulating low density components and/or intermediate density components at the separation disc second port; wherein the high density component accumulates to a level detected by the detector; wherein the first detector is configured to transmit a signal to the control system; wherein the control system is further configured to direct the valve to open allowing low density components and/or intermediate density components to flow from the separation disc outlet port into the concentrator and onto the retentate sides of the membranes; wherein the membranes allow the low molecular weight molecules to pass from the retentate sides to the permeate sides, thereby concentrating the low density components and/or intermediate density components; wherein the second detector is configured to detect when RBCs begin to exit the separation disc, whereby the control system is configured to stop or reverse the pump; and wherein the apparatus and control system are configured to prepare concentrated blood components.