Patent ID: 8501181
Filing Date: 2013-08-06
Classification: A61P,C07K,Y10T

Abstract:
1. A method for treating osteotropic cancer arising from a metastatic breast cancer in a subject, the method comprising administering to the subject an effective amount of an antibody that specifically binds to a MMP-14polypeptide comprising SEQ ID NO: 1, wherein the antibody inhibits the activity of MMP-14 and comprises a heavy chain immunoglobulin variable domain sequence and a light chain immunoglobulin variable domain, wherein the heavy chain immunoglobulin variable domain sequence comprises the heavy chain CDR1, CDR2 and CDR3 of SEQ ID NO:22 and the light chain immunoglobulin variable domain sequence comprises the CDR1, CDR2 and CDR3 of SEQ ID NO: 23, thereby treating the osteotropic cancer in the subject.