Patent ID: 8188254
Filing Date: 2012-05-29
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. An immunostimulatory nucleic acid molecule of Formula I wherein each of Z each of X each of Y each of R each of N and N′ is independently any sequence 0 to 12 nucleotides long which optionally comprises a non-nucleotidic linker or abasic dSpacer; S S each of N k is an integer from 0 to 5; n is an integer from 2 to 16; p is an integer from 1 to 6; and q is an integer from 0 to 10, and wherein when (N n ) . . . (N 2 )(N 1 ) S 2 (N 1# )(N 2# ) . . . (N n# ) is 10 to 42 nucleotides long, S 2 is 6 to 10 nucleotides long or is a non-nucleotidic linker, an abasic linker (dSpacers), triethylene glycol units or hexaethylene glycol units, and/or (N n ) . . . (N 2 )(N 1 ) S 2 (N 1# )(N 2# ) . . . (N n# ) has a GC content that is less than ⅔′.