Patent ID: 6605305
Filing Date: 2003-08-12
Classification: A61K

Abstract:
A process for producing schisandrin from fruit of Schisandra chinensis (Turcz) Baill comprising:a. extracting the dried powder of the fruit of Schisandra chinensis with boiling water; b. filtering the extract of water and obtaining filter residue; c. extracting said filter residue with 80% ethanol; d. obtaining a residue from the 80% ethanol extract by recovering said ethanol under reduced pressure; e. extracting said residue from step d with 80% ethanol-gasoline (1:1); f. obtaining a layer of ethanol; g. concentrating the ethanol layer; h. obtaining a crude crystal under reduced pressure from the concentrated ethanol layer; i. dissolving the crude crystal in benzene; j. filtering the benzene; k. obtaining a residue of benzene by recovering said benzene; l. dissolving the residue of benzene in ethanol to obtain a solution of crystalloid material; m. drying the solution of crystalloid material to obtain a dried powder; n. passing the dried powder through a column packed with A1203 and eluting the column using petroleum ether-benzene (1:1) to obtain an elutant; o. concentrating said elutant under-reduced pressure to obtain crystals; p. recrystallizing the crystals to produces Schisandrin in a crystalline form.