Patent ID: 9120869
Filing Date: 2015-09-01
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A method of eliciting in a subject an immune response, comprising administering to the subject an immunogenic composition comprising an engineered Plasmodium vivax Duffy Binding Protein (PvDBPII) comprising a modified region corresponding to an dominant immunogenic polymorphic B-cell epitope region of a native PvDBPII, wherein said modified region comprises the amino acid sequence SEQ ID NO: 4 (ASTAATSRTS), and wherein said modified region has reduced immunogenic dominance when compared to the region of a native PvDBPII comprising the amino acid sequence SEQ ID NO: 3 (DEKAQQRRKQWWNESK), and wherein the elicited immune response has increased binding specificity for conserved Duffy binding epitopes of a Plasmodium Duffy Binding Protein when compared to an immune response generated by a natural PvDBPII.