Patent ID: 8658593
Filing Date: 2014-02-25
Classification: A61K,A61P

Abstract:
1. A method of transferring Inter-α-Inhibitor (lαl) heavy chains (HCs) from high molecular weight (HMW) hyaluronic acid (HA) to low molecular weight (LMW) hyaluronic acid (HA), within a site of inflammation caused by rheumatoid arthritis in an individual in need thereof, comprising administering to the site: a) a LMW HA compound comprising the hyaluronan-containing structure of: wherein: A is hydrogen; B is hydroxyl; x=0 or 1; y=0 or 1; and n=3 to 70, with the proviso that if n=3, then at least one of x and y=1 and b) a protein selected from the group consisting of mammalian TSG-6 protein, recombinant mammalian TSG-6 protein, human TSG-6 protein, and recombinant human TSG-6 protein, in amounts of a) and b) effective to transfer the IαI HCs from the HMW HA to the LMW HA compound.