Patent ID: 6472394
Filing Date: 2002-10-29
Classification: A61K,A61P,C07D

Abstract:
A compound represented by the structural formula or a pharmaceutically acceptable salt, ester or solvate thereof, whereinW is R1â€”CR3R12NR4C(O)â€”; the dotted line is an optional double bond; X is â€”CHR8â€”, â€”C(O)â€”, â€”C(&boxH;NOR9)â€”, or, when the double bond is present, â€”CR8&boxH;; Y is â€ƒor, when the double bond is present, R1 is R5â€”(C3-C8)cycloalkyl, R5â€”(C3-C8)cycloalkyl(C1-C8)alkyl, R5-aryl, R5-aryl-(C1-C6)alkyl, R5-heteroaryl, R5-heteroaryl(C1-C6)alkyl, R5-heterocycloalkyl or R5-heterocycloalkyl(C1-C6)alkyl; R2 is R6-aryl or R6-heteroaryl; n is 1, 2 or 3; R3 is C1-C6 alkyl, aryl or heteroaryl; R4 is H or C1-C6 alkyl; R5 is 1-4 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, C1-C6 alkoxy, â€”CF3, (C1-C6)-alkoxycarbonyl, â€”SO2NHR4, â€”C(O)NHR4, â€”NR4C(O)NHR4, â€”NR4C(O)R4, â€”NR4SO2R4, R13-phenyl and naphthyl; R6 is 1-4 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, â€”SH, â€”S(C1-C6 alkyl), â€”CN, C1-C6 alkoxy, C1-C6 alkylcarboxy, CF3, â€”NO2, â€”NH2, (C1-C6)alkylamino, phenyl, (C1-C6)-alkoxycarbonyl and R7-phenoxy, or adjacent ring carbon atoms form a ring with the group â€”O(CH2)1-2Oâ€”, â€”O(CH2)2-3â€” or â€”O(CF2)Oâ€”; R7 is 1-3 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, C1-C6 alkoxy and CF3; R8 is H, C1-C6 alkyl or (C1-C4)alkoxy-(C1-C4)alkyl; R9 is H, C1-C6 alkyl or aryl-(C1-C4)alkyl; R10 is independently selected from the group consisting of H, C1-C6 alkyl and aryl; R12 is H or C1-C6 alkyl; and R13 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, C1-C6 alkoxy, â€”CF3, â€”OCF3, â€”NO2 and â€”C(O)CH3.