Patent ID: 8492349
Filing Date: 2013-07-23
Classification: C07K

Abstract:
1. A method for selecting a compound for VAKGL-binding activity from candidate compounds that comprises the steps of: a) providing a candidate compound pharmacophore prepared by determining the aromatic/hydrophobic and hydrogen bond acceptor functions and the distances there between of said candidate compound; b) comparing said candidate compound pharmacophore to the pharmacophores of c) selecting a compound that exhibits at least three of the pharmacophores shown in d) admixing a compound so selected with an aqueous composition of an isolated polypeptide that includes at least the amino acid sequence Val-Ala-Lys-Gly-Leu (SEQ ID NO: 14) and determining the binding affinity of that compound to said polypeptide; and e) further selecting a compound for VAKGL-binding activity that exhibits a binding affinity of about 5e