Patent ID: 6630588
Filing Date: 2003-10-07
Classification: A61P,C07D,C09B,G01N

Abstract:
A compound of the formula (I): wherein:R1 is a spacer group selected from R2 is hydrogen, alkyl, hydroxyalkyl, haloalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, amidoalkyl, alkylamidoalkyl, dialkylamidoalkyl, alkanoylalkyl, azidoalkyl, carbamoylalkyl, alkyl optionally interrupted by a heteroatom; alkenyl, alkenyloxyalkyl; cycloalkylalkyl, heterocycloalkyl; aryl, aralkyl, aralkenyl, heteroarylalkyl, in which aryl is optionally substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino or dialkylamino; aroylalkyl, or heteroaroylalkyl; R3 and R4 are each independently hydrogen, alkyl, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino, dialkylamino, or when taken together, R3 and R4 form a fused aryl or heteroaryl group that is optionally substituted by one or more substituents selected from alkyl if 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino, dialkylamino, hydroxy and alkoxymethyl; wherein the heteroaryl group is a single 6 membered ring containing one nitrogen heteroatom; and DYE is a dye moiety selected from the group consisting of dipyrrometheneboron difluoride dyes, fluorescein dyes, rhodamine dyes, and Texas Red; or pharmaceutically acceptable acid addition salt thereof.