Patent ID: 7282568
Filing Date: 2007-10-16
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated human monoclonal antibody which binds to human IL-8, wherein the antibody comprises a human heavy chain variable region comprising CDR1 as set forth in SEQ ID NO 22, CDR2 as set forth in SEQ ID NO 23, and CDR3 sequences and a human light chain variable region comprising CDR1 as set forth in SEQ ID NO 16, CDR2 as set forth in SEQ ID NO 17, and CDR3 sequences, wherein the V L CDR3 domain comprises the amino acid sequence: wherein X 1 , X 2 and X 3 each represents a natural amino acid residue, and X 1 is different from Gly, or X 2 is different from Ser, or X 3 is different from Pro and the V wherein X 4 is Lys, Arg, or His, and X 5 is Gly, Ala, Val, Leu, or Ile.