Patent ID: 8198033
Filing Date: 2012-06-12
Classification: A61P,G01N

Abstract:
1. A method of detecting apoptosis in a mammalian cell comprising: (a) contacting the cell with an antibody that binds to a protein fragment generated during apoptosis, wherein the antibody binds to a protein fragment of AP2-α (SEQ ID NO: 1) (b) determining the amount of the antibody which binds to the protein fragment of AP2-α generated during apoptosis; and (c) comparing the amount of antibody bound in step (b) with the amount of antibody which binds to the protein fragment of AP2-α in a mammalian cell free of apoptosis, wherein if the amount in step (b) is greater than the amount in the cell free of apoptosis, then apoptosis is detected.