Patent ID: 6034242
Filing Date: 2000-03-07
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of Formula 1 ##STR10## wherein Z is the group shown in Formula 3, ##STR11## Y is cyclopropyl, said Y group being optionally substituted with one or two R.sub.4 groups, the divalent Y radical being substituted by the Z and --(CR.sub.1 .dbd.CR.sub.1 --CR.sub.1 .dbd.CR.sub.1)-- groups on adjacent carbons;X is NR.sub.5 ;R.sub.1 and R.sub.2 independently are H, lower alkyl or fluoroalkyl;R.sub.3 is hydrogen, lower alkyl, Cl or Br;R.sub.4 is lower alkyl, fluoroalkyl or halogen;R.sub.5 is H or lower alkyl, andB is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 OR.sub.13 O, or tri-lower alkylsilyl, where R.sub.7 is an alkyl of 1 to 5 carbons; cycloalkyl of 3 to 5 carbons or alkenyl group containing 2 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, a cycloalkyl group of 5 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11 is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons.