Patent ID: 9146242
Filing Date: 2015-09-29
Classification: A61P,G01N

Abstract:
1. A method of treating an individual with systemic lupus erythematosus (SLE) comprising: (a) detecting native BLyS/APRIL heterotrimer (HT) protein levels of the individual comprising measuring a first level of native HT protein in a serum sample from said individual wherein measuring utilizes a bead-based immunoassay employing an anti-APRIL antibody and an anti-BLyS antibody; (b) comparing said first native HT protein level to a second native HT protein level in a serum sample of a healthy individual; (c) determining whether said first native HT protein level is increased as compared to said second native HT protein level, wherein said increased first native HT protein level is associated with SLE; and wherein said native HT protein causes proliferation of B cells and production of immunoglobulin in an in vitro assay; (d) selecting a treatment plan for individuals with SLE and having an increase in HT levels; and, (e) administering said treatment plan to said individual, wherein said treatment plan comprises administration of an HT antagonist.