Patent ID: 8748481
Filing Date: 2014-06-10
Classification: A61K,A61P,C07D

Abstract:
1. A method for the long term treatment of chronic constipation in a human subject, wherein the treatment comprises administering to the subject in need thereof an effective amount of a prostaglandin compound represented by Formula (I) and/or its tautomer: wherein W wherein R X R Y is a saturated or unsaturated C A is —COOH or its salt, ester or amide; R1 is a saturated or unsaturated, straight chain or branched chain lower hydrocarbon; the bond between C-13 and C-14 positions is double or single bond, and the steric configuration at C-15 position is R, S or a mixture thereof, wherein said prostaglandin compound is administered for over 4 weeks, wherein the treatment induces substantially no serum electrolyte shifting during the term of treatment, wherein the amount of said prostaglandin compound to be administered is in the range of about 6-48 μg per day, and wherein the treatment improves quality of life of the subject.