Patent ID: 6548530
Filing Date: 2003-04-15
Classification: A61P,C07C,C07D

Abstract:
A compound represented by the following structure: wherein:A is selected from the group consisting of NH and O; B is selected from the group consisting of C and N; R2 is incorporated into a first N-substituted pyrrolidine ring containing V1, a double bond between R2 and R3, or is selected from the group consisting of hydrogen, hydroxyl, and O-alkyl (C1-C6); R3 is incorporated into the first N-substituted pyrrolidine ring containing V1, a double bond between R2 and R3, or is NHâ€”C(O)â€”R6; R4 is selected from the group consisting of hydrogen, hydroxyl, and O-alkyl (C1-C6); R5 is selected from the group consisting of hydrogen, hydroxyl, and O-alkyl (C1-C6); and the first N-substituted pyrrolidine ring containing V1 being fused to the double bond between R2 and R3 and being represented by the following structure: â€ƒwherein: R6 is a radical represented by the following structure: â€ƒwherein: E is selected from the group consisting of NH, S, and O; D is selected from the group consisting of C and N; R7 is incorporated into a second N-substituted pyrrolidine ring containing V2, a double bond between R7 and R8, or is selected from the group consisting of hydrogen, hydroxyl, and O-alkyl (C1-C6); R8 is incorporated into a second N-substituted pyrrolidine ring containing V2, a double bond between R7 and R8, or is selected from the group consisting of hydrogen, hydroxyl, and O-alkyl (C1-C6); the second N-substituted pyrrolidine ring containing V2 being fused to the double bond between R7 and R8 and being represented by the following structure: â€ƒwherein: R9 is selected from the group consisting of â€”CH2CH3, -alkyl, â€”NHCH3, â€”N-alkyl, â€”OCH3, â€”O-alkyl, â€”NH2, â€”NHNH2, and â€”NHNHCO2-t-Bu, with the following provisos:if R2 participates in the first N-substituted pyrrolidine ring, then R3 also participates in the first N-substituted pyrrolidine ring; if R3 participates in the first N-substituted pyrrolidine ring, then R2 also participates in the first N-substituted pyrrolidine ring; if R7 participates in the N-substituted pyrrolidine ring, then R8 also participates in the N-substituted pyrrolidine ring; if R8 participates in the N-substituted pyrrolidine ring only if R7 also participates in the N-substituted pyrrolidine ring; if A and E are simultaneously NH, then B and D can not simultaneously be C; and if E is S, then B and D are C.