Patent ID: 6593301
Filing Date: 2003-07-15
Classification: A61K,A61P

Abstract:
A method for the prophylaxis or treatment of dementia comprising administering a prophylactically or treatment effective amount of a compound of Formula I or stereoisomer thereof to a subject in need of such prophylaxis or treatment, whereinR1 is hydrogen, â€”OH, â€”O-Xyl, â€”O-Ara-Rha, â€”O-Fuc-Rha, â€”O-Ara-Rha, R2 is hydrogen, â€”OH, â€”O-Fuc, â€”O-Rha, or â€”O-Glu; R3 is â€”OCOCH3, â€”OCOC15H31, or â€”O-Gal-Glu, â€”O-Glu-Glu, â€”O-Glu-Ara, â€”O-Fuc-Glu, â€”O-Rha-Glu, â€”O-Glu-Glu-Glu, â€”O-Glu-Rha, â€”O-Man-Glu, â€”O-Gal-Glu-Glu, â€”O-Gal-Glu-Gal, R4 is hydrogen, â€”OH, or â€”OSO3Na, R5 is hydrogen, hydroxy, â€”O-Glu, or is absent, R6 is hydrogen, â€”OH, oxo(&boxH;O), â€”O-Qui-Rha, or â€”O-Qui-Xyl; R12 is hydrogen, â€”OH, or oxo(&boxH;O); R14 is hydrogen, or â€”OH; R15 is hydrogen, or â€”OH; R22 is hydroxy, or O(CH2)nCH3, n=0Ëœ3, or is absent, R23 is hydrogen, or â€”OH; R27 is â€”CH3, â€”CH2OH, or &boxH;CH2; X is O, or NH;  denotes a single bond or a double bond, Y is a direct bond or is absent, Z is Glu or is absent, provided that a compound of Formula I wherein R1&boxH;R2&boxH;R4&boxH;R6&boxH;R12&boxH;R14&boxH;R15&boxH;R23=H, R3=&bgr;-OH, R5=&bgr;-H, X=O,  is a single bond, Y is a direct bond, R22 is absent, Z is absent, R27 is â€”CH3, and C25 is (S) configuration, is not included.