Patent ID: 6805881
Filing Date: 2004-10-19
Classification: A61K,A61P

Abstract:
A process for the production of an orally administratable multiple-unit sustained-release pharmaceutical composition having controlled agitation-independent release, consisting essentially of the steps of (a) combining hydroxypropylcellulose polymer having a molecular weight of 250000 to 1200000 and a molar degree of substitution of at least 3 in an amount from 40 to 95% by weight with a pharmaceutically active compound and optionally with one or more pharmaceutically acceptable additional polymers and/or excipients which do not contribute significantly to a sustained-release effect, to obtain a mixture of containing said hydroxypropyl cellulose polymer and said active compound; (b) converting said mixture into particles having a diameter of 0.2 to 3.0 mm; (c) optionally lacquering said particles, and (d) incorporating said particles into an orally administratable multi-unit sustained release dosage form.