Patent ID: 6852878
Filing Date: 2005-02-08
Classification: A61K,C07C,C07H

Abstract:
1. A compound of formula (1), or a pharmaceutically acceptable salt thereof: wherein a) Ra Rb Rc and Rd are independently any group that does not adversely affect the desired properties of the molecule, including hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, arakyl, or substituted aralkyl; and b) Z is (i) a substituted or unsubstituted carbohydrate, (ii) a substituted or unsubstituted alditol, (iii) C1-10 alkyl or substituted C1-10 alkyl, terminated by sulfonic acid, or ii) C1 alkyl or substituted C1-10 alkyl, terminated by phosphonic acid, (v) substituted or unsubstituted C1-10 alkyl OC(O)C1-10 alkyl, (vi) straight chained polyhydroxylated C2-10 alkyl; (vii) (CR2)1-6COOH, wherein R is independently hydrogen, hale, amino, or hydroxy, and wherein at least one of the R substituents is not hydrogen; or (viii) (CR2)1-6X, wherein X is aryl, heteroaryl, or heterocycle, and R is independently hydrogen, hale, amine, or hydroxy.