Patent ID: 7893016
Filing Date: 2011-02-22
Classification: C07H,C12N

Abstract:
1. A method for increasing the yield of a nucleic acid duplex during purification process, comprising the step of contacting a nucleic acid duplex with a composition which comprises divalent cations and a purified ubiquitin-like protein, wherein: a) the ubiquitin-like protein comprises the following amino acid sequence (SEQ ID NO: 1): KXXX wherein X is any amino acid, X X X X X X and b) the ubiquitin-like protein is selected from the group consisting of a fusion protein, a tandem repeat protein, a precursor, a mature protein, glycosylated, unglycosylated, methylated, labeled, and with or without N-terminal methionine provided that duplex stabilization activity is retained.