Patent ID: 8380539
Filing Date: 2013-02-19
Classification: G16H

Abstract:
1. Personalized medicine management software stored on a non-transitory computer medium for causing a computer to determine a series of a recommended doses of an anticoagulant medication for a patient, the software containing code for causing a computer to conduct the following steps: receiving information regarding a combination of the genotypes of VKORC1 and CYP2C9 and personal attributes for the patient that are predictive of the patient's reaction to a series of doses of the anticoagulant medication; with a predictive mathematical model specific to the medication, calculating a series of recommended doses specific to the patient's at least one genetic factor and personal attributes specific to the medication, wherein the model predicts maintenance dose series based upon the patient's VKORC1 and CYP2C9 and a calculated clearance of the anticoagulant medication; receiving actual dose and measured patient response data and adjusting the patient's calculated clearance of the medication based on CYP2C9 genotype and a target blood concentration required for optimal therapeutic response that is adjusted based on the VKORC1; graphically displaying a representation of dosing and concentration, wherein the representation graphically represents time for blood concentrations of the anticoagulant medication to achieve or transition to a steady-state for a given dosing, and wherein the graphic dosing rate is changed in response to said step of receiving and wherein the graphical representation of anticoagulant medication concentrations in blood are plotted in conjunction with measured medication response to add temporal dimension to the interpretation of the medication response parameter; and wherein the representation that is graphically displayed includes overlays of anticoagulant medication concentration, measured medication response, and dosing over time and wherein the representation is updated in real time after said step of receiving.