Patent ID: 6534040
Filing Date: 2003-03-18
Classification: A61K,C07D

Abstract:
A compound of the formula: wherein: â€”(CH2)2CONHphenyleneCH2DTPA, where R9&boxH;â€”OR10 where R10 is lower alkyl of 1 though 6 carbon atoms;R2 is â€”CH3, R5 is â€”CH2CH3, and R3 and R4 together form a covalent bond or R2 and R3 together are &boxH;O, R4 is â€”CH2CH3 and R5 is â€”CH3; R6 is â€”NR11- or a covalent bond; R7 is &boxH;O when R6 is â€”NR10âˆ’ and R7 is a covalent bond; and R8 is â€”(CH2)CO2CH3, â€”(CH2)CO2CH3, â€”(CH2)2CONHphenyleneCH2DTPA, â€ƒR11 is lower alkyl of 1 through 6 carbon atoms, â€”(CH2)2CONHphenyleneCH2DTPA, â€ƒprovided that only one of R1, R8 or R11 is â€”(CH2)2CONHphenyleneCH2DTPA, â€ƒor a metal complex thereof.