Patent ID: 6630581
Filing Date: 2003-10-07
Classification: C07B,C07H,C40B,Y02P

Abstract:
A nucleoside monomer having the structure of formula (II) wherein:B is a purine or pyrimidine base; R is hydrido or hydroxyl; R1 is COOR3, wherein R3 is selected from the group consisting of o-nitrophenyl, phenyl, n-chlorophenyl, 5â€²-(&agr;-methyl-2-nitropiperonyl), 1,1-dimethyl-2,2,2-trichloroethyl, and cyano-substituted lower alkyl moieties; and R2 has the structure (III) wherein X is NQ1Q2 in which Q1 and Q2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkaryl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl or cycloalkynyl, optionally containing one or more nonhydrocarbyl linkages and optionally substituted on one or more available carbon atoms with a nonhydrocarbyl substituent, or wherein Q1 and Q2 are linked to form a mono- or polyheterocyclic ring, and Y is selected from the group consisting of hydrido, lower alkyl, electron-withdrawing &bgr;-substituted aliphatic, electron-withdrawing substituted phenyl, and electron-withdrawing substituted phenylethyl.