Patent ID: 6710088
Filing Date: 2004-03-23
Classification: A61K,A61P,C07C,C07D

Abstract:
A pharmaceutical composition comprising a therapeutically effective amount of a calcium receptor-modulating compound having the formula: wherein Ar1 is either optionally substituted naphthyl, optionally substituted phenyl, or an optionally substituted heterocyclic aryl, wherein up to S substituents may be present and each substituent is independently selected from the group consisting of: alkyl, alkenyl, halogen, alkoxy, thioalkyl, methylene dioxy, halo alkyl, haloalkoxy, OH, CH2OH, CONH2, CN, acetoxy, N(alkyl)2, phenyl, phenoxy, benzyl, benzyloxy, &agr;-&agr;-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl, OCH2COOH, and ethylene dioxy; Ar2 is either optionally substituted naphthyl or optionally substituted phenyl wherein up to 5 substituents may be present and each substituent is independently selected from the group consisting of: alkyl, alkenyl, halogen, alkoxy, thioalkyl, methylene dioxy, haloalkyl, halo alkoxy, OH, CH2OH, CONH2, CN, OCH2COOH, ethylene dioxy, and acetoxy; q is 0, 1, 2, or 3 provided that if q is 2, then Ar2 is not an unsubstituted phenyl; R1 is either H or alkyl; and R2 and R3 are each independently either an alkyl, or together cycloalkyl or cycloalkenyl; or a pharmaceutically acceptable salt or complex thereof; and a pharmaceutically acceptable carrier.