Patent ID: 8329217
Filing Date: 2012-12-11
Classification: A61K

Abstract:
1. A dual controlled release osmotic device comprising: a) a core comprising a first active agent-containing controlled release layer and a second active agent-containing controlled release layer in direct contact therewith, wherein the second active agent-containing layer surrounds the first active agent-containing layer; and the osmotic device excludes a push-layer; and b) a membrane surrounding the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing controlled release layers; whereby the osmotic device provides a controlled release of the first active agent through the at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active through the at least one preformed passageway according to a second release profile, and wherein the first drug and the second drug are released sequentially when the device is exposed to an aqueous environment of use.