Patent ID: 6525085
Filing Date: 2003-02-25
Classification: A61P,C07C,C07D

Abstract:
A compound of Formula I: whereinAr1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of alkyl, alkoxy, cycloalkyl, cycloalkyoxy, heterocycloalkyl, heterocycloalkyloxy, alkanoyl, thioalkyl, aralkyl, aralkyloxy, aryloxyalkyl, aryloxyalkoxy, cycloalkyl-substituted alkyl, cycloalkyloxy-substituted alkyl, cycloalkyl-substituted alkoxy, cycloalkyloxy-substituted alkoxy, heterocycloalkyl-substituted alkyl, heterocycloalkyloxy-substituted alkyl, heterocycloalkyl-substituted alkoxy, heterocycloalkyloxy-substituted alkoxy, thioaryl, aralkylthio, thioaryl-alkyl, aralkylthioalkyl, halo, NO2, CF3, CN, OH, alkylenedioxy, SO2NRRâ€², NRRâ€², CO2R (where R and Râ€² are independently selected from the group consisting of H and alkyl), and a second aryl group, which may be substituted as above; wherein at least one of the aryls is a five-membered aryl containing at least one heteroatom, (wherein said heteroatom is selected from the group consisting of O, N, and S); R1 is selected from the group consisting of H and alkyl; R2 is selected from the group consisting of H, alkyl and benzyl; R3 is selected from the group consisting of CO2R, CONRRâ€², CONH(OH), COSR, SO2NRRâ€², PO(OR)(ORâ€²) and tetrazolyl, wherein R and Râ€² are independently selected from the group consisting of H and alkyl; and a salt, solvate or hydrate thereof.