Patent ID: 8268345
Filing Date: 2012-09-18
Classification: A61K,A61P

Abstract:
1. A sterile hydrogel composition comprising polyvinyl alcohol (“PVA”), polyvinyl pyrrolidone (“PVP”), and a polysaccharide, wherein the PVA is present in an amount of from 2% to 4% weight by volume based on the total volume of the composition; the PVP is present in an amount of from 3% to 5% weight by volume based on the total volume of the composition; the polysaccharide is selected from the group consisting of κ-carrageenan, agar-agar, and a combination thereof and present in an amount of 1% to 4% weight by volume based on the total volume of the composition; and the sterile hydrogel composition has a gel fraction greater than or equal to 97%, wherein the sterile hydrogel composition is produced by forming an aqueous solution of the PVA, The PVP and the polysaccharide; setting the solution to form a thermoreversible gel matrix; and simultaneously crosslinking and sterilizing the thermoreversible gel matrix by irradiation with ionizing radiation at a dose of from about 15 kGy to about 65 kGy.