Patent ID: 8852880
Filing Date: 2014-10-07
Classification: A61K,A61P,C12Q,C12Y,G01N

Abstract:
1. An in-vitro method for assaying a patient's compatibility to asparaginase therapy comprising: (a) obtaining a sample of blood, plasma, or serum from a patient; (b) incubating said sample with a known amount of asparaginase for a period of time sufficient to produce antibody-asparaginase immune complexes; (c) removing from the incubated sample any antibody-asparaginase immune complexes formed during incubation step (b) and recovering a sample free of antibody-asparaginase immune complexes; (d) incubating the sample obtained at step (c) with asparagine, (e) determining a residual asparaginase activity or the amount of asparaginase residual activity in the resultant mixture of step (d).