Patent ID: 6258851
Filing Date: 2001-07-10
Classification: A61P,C07C

Abstract:
A compound of formula (I) ##STR18##wherein:n is 0 or 1;A represents an optionally substituted phenyl or pyridryl group;B represents a divalent 1,4-phenylene moiety or a divalent C.sub.1 -C.sub.4 alkylene or C.sub.2 -C.sub.4 alkenylene or C.sub.2 -C.sub.4 alkynylene moeity;X represents --C(.dbd.O)-- or --S(.dbd.O).sub.2 --,R.sub.1 and R.sub.2(i) independently representhydrogen,a C.sub.1 -C.sub.6 alkyl group, ora group D-(C.sub.1 -C.sub.6 alkyl)- wherein D representsa 5- or 6-membered N-heterocyclic ring which (a) is attached via the N atom, (b) optionally contains N, O and/or S, SO or SO.sub.2 as an additional ring member, (c) is substituted by oxo on one or both C atoms adjacent to the linking N atom and (d) is optionally benz-fused or optionally substituted on one or more other C atoms by C.sub.1 -C.sub.6 alkyl, or oxo and/or on any additional N atoms by C.sub.1 -C.sub.6 alkyl, phenyl or heteroaryl; or(ii) taken together with the carbon atom to which they are attached form a cycloalkyl or cycloalkenyl ring;R.sub.3 represents:(a) an optionally substituted cycloalkyl or cycloalkenyl ring or(b) a group --CHR.sup.x R.sup.y wherein (i) R.sup.x and R.sup.y each independently represents an optionally substituted phenyl or heteroaryl group which may be linked covalently to each other by a bond or by a divalent C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkenyl bridge, or (ii) R.sup.x represents a group D-(C.sub.1 -C.sub.6 alkyl)- wherein D is as defined above in relation to R.sub.1 and R.sub.2, or is an optionally substituted phenyl or heteroaryl, group, and R.sup.y represents an optionally substituted phenyl or heteroaryl ring;(c) a group of formula -(Z'--O).sub.w -Z wherein Z' is straight or branched C.sub.1 -C.sub.6 alkyl optionally interrupted by one or more non-adjacent S and/or N atoms, w is an integer >1, and no continuous linear sequence of atoms in the group R.sub.4 is >12, or(d) hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 perfluoroalkyl, or a group D-(C.sub.1 -C.sub.6 alkyl)- wherein D is as defined above in relation to R.sub.1 and R.sub.2, or is hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, acylamino, optionally substituted phenyl or heteroaryl, NH.sub.2, or mono- or di-(C.sub.1 -C.sub.6 alkyl)amino;or R.sub.3 and R.sub.4 taken together represent a divalent chain of formula -C(R.sup.a)(R.sup.b)-A.sup.1 -Alk- wherein R.sup.a and R.sup.b are independently hydrogen or C.sub.1 -C.sub.6 alkyl, A.sup.1 is a bond, --O --, --S --, --S --S --, --NH-- or --NR.sup.a -- wherein R.sup.a is C.sub.1 -C.sub.6 alkyl, and Alk is a divalent C.sub.1 -C.sub.4 alkylene moeity;R.sub.4 represents hydrogen or a C.sub.1 -C.sub.6 alkyl group;R.sub.5 represents hydrogen or acyl; andR.sub.6 represents hydrogen, a C.sub.1 -C.sub.6 alkyl group, or a group D-(C.sub.1 -C.sub.6 alkyl)- wherein wherein D is as defined above in relation to R.sub.1 and R.sub.2 ;or a pharmaceutically acceptable salt, hydrate or solvate thereof.