Patent ID: 6794154
Filing Date: 2004-09-21
Classification: A01K,A61K,C07K,C12N,C12Q,G01N

Abstract:
A method for screening or identifying therapeutic or prophylactic agents for renal disease, which comprises assaying a test substance for the activity of up-regulating the expression of liver-type fatty acid-binding protein (L-FABP) in animal cell, wherein said assay comprises the following steps:(1) culturing animal cell in the presence or absence of the test substance; and comparing the amount of L-FABP expressed in the cell in the presence of the test substance with the amount of L-FABP expressed in the cell in the absence of the test substance; or (2) administering the test substance to an animal and comparing the amount of L-FABP expressed in renal tissues or cells of the animal with the amount of L-FABP expressed in renal tissues or cells of a non-treated animal, wherein the animal cell is kidney cell or tissue.