Patent ID: 8962590
Filing Date: 2015-02-24
Classification: A61K,A61P,C12N,G01N

Abstract:
1. A method for inducing an immune reaction to androgen receptor in a mammal having prostate cancer, the method comprising the step of: administering to the mammal an effective amount of a DNA vaccine comprising a polynucleotide operatively linked to a transcriptional regulatory element, wherein the polynucleotide encodes a fragment of a mammalian androgen receptor consisting essentially of the ligand-binding domain of the receptor, the ligand-binding domain fragment selected from the group consisting of (i) SEQ ID NO:9, (ii) SEQ ID NO:10, (iii) SEQ ID NO:11, and (iv) SEQ ID NO:12, whereby the mammal develops an immune reaction against androgen receptor.