Patent ID: 6645950
Filing Date: 2003-11-11
Classification: A61K,A61P,C07D,C07F

Abstract:
A composition for treatment of diseases involving angiogenesis comprising at least one 5(6)-substituted benzimidazole-2-carbamate of formula I in an amount sufficient to damage new vasculature: wherein:alk is an alkyl group; X is oxygen, sulfur, sulphinyl, sulphonyl, carbonyl (CO), thiocarbonyl (CS), sulphonyloxy, NH, iminomethylene (C&boxH;NH), N-hydroxyiminomethylene, N-alkoxyiminomethylene, dialkoxymethylene, 1,3-dioxolan-2yl, 1,1-ethenyl, a group CHR3 or a bond; R1 is hydrogen, alkylaminocarbonyl oralkoxycarbonyl; R2 is hydrogen, alkoxycarbonyl, cyanomethyl, cyanoethyl, alkoxymethyl or acetoxymethyl; R3 is hydrogen, hydroxy, alkoxy or amino; A is a substituted aromatic ring or substituted alkyl group in which at least one substituent is Y selected from phosphate, alkylphosphate, NHCOR4 and NR5COR4 where R4 and R5, which may be the same or different, are each an alkyl group substituted with one or more substituents selected from hydroxy, amino, alkylamino, guanidino, carboxyl, SO3H, sulfate and phosphate; and prodrugs and pharmaceutically acceptable salts, solvates and hydrates thereof.