Patent ID: 8877926
Filing Date: 2014-11-04
Classification: C07D

Abstract:
1. A process for obtaining a compound of formula III or a salt thereof: wherein R1 is a hydrogen atom, F, Cl, I, Br, (C and R2 is a heteroaryl residue selected from the series consisting of pyrrole, furan, thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole, tetrazole, 1,2,3,5-oxathiadiazole-2-oxides, triazolones, oxadiazolone, isoxazolone, oxadiazolidinedione, triazole, 3-hydroxypyrrole-2,4-diones, 5-oxo-1,2,4-thiadiazoles, pyridine, pyrazine, pyrimidine, indole, isoindole, indazole, phthalazine, quinoline, isoquinoline, quinoxaline, quinazoline, cinnoline and β-carboline, wherein the heteroaryl residue is unsubstituted or is substituted once, twice or three times, independently of each other, by substituents selected from the series consisting of (C R5 is —NH said process comprising a) mixing a compound of formula II: wherein R1 and R2 are as defined above, and R3 is a hydrogen atom, or (C or an aryl residue selected from the series consisting of phenyl, naphthyl, 1-naphthyl, 2-naphthyl, biphenylyl, 2-biphenylyl, 3-biphenylyl, 4-biphenylyl, anthryl and fluorenyl, wherein the aryl residue is unsubstituted or is substituted, independently of each other, once, twice or three times by substituents selected from the series consisting of —NO or —O—C(CH or —O—CH(R7)-aryl, wherein the aryl residue is selected from the series consisting of phenyl, naphthyl, 1-naphthyl, 2-naphthyl, biphenylyl, 2-biphenylyl, 3-biphenylyl, 4-biphenylyl, anthryl and fluorenyl and is unsubstituted or is substituted, independently of each other, once, twice or three times by substituents selected from the series consisting of —NO in an organic solvent or a mixture of organic solvents with an enantiomerically pure auxiliary; b) separating the salt composed of enantiomerically pure auxiliary and compound of formula I: by fractional crystallization; c) isolating the compound of formula I from the salt composed of enantiomerically pure auxiliary and compound of formula I; d) converting the resulting compound of formula I with ammonia or an amine of the formula H or a salt thereof; and e) converting the resulting compound of formula IV or salt thereof into the compound of formula III or a salt thereof.