Patent ID: 6297274
Filing Date: 2001-10-02
Classification: C07D

Abstract:
A compound of formula ##STR59##or a tautomeric open chain keto-acid form thereof or a pharmaceutically acceptable salt thereof whereinR.sub.1 is cycloalkyl of from 3 to 12 carbon atoms substituted or unsubstituted, phenyl substituted with from 1 to 5 substituents, naphthyl unsubstituted or substituted with from 1 to 5 substituents, or heteroaryl unsubstituted or substituted with from 1 to 5 substituents;R.sub.2 is straight or branched alkyl of from 1 to 12 carbon atoms substituted or unsubstituted, cycloalkyl of from 3 to 12 carbon atoms substituted or unsubstituted, aryl unsubstituted or substituted with from 1 to 5 substituents, or heteroaryl unsubstituted or substituted with from 1 to 3 substituents;R.sub.3 is straight or branched alkyl of from 1 to 12 carbon atoms substituted or unsubstituted, cycloalkyl of from 3 to 12 carbon atoms substituted or unsubstituted, aryl which is unsubstituted or substituted with from 1 to 5 substituents, or heteroaryl unsubstituted or substituted with from 1 to 3 substituents; andat least one of R.sub.1 or R.sub.2 or R.sub.3 is independently substituted by a total of from 1 to 4 substituents which enhance aqueous solubility, said substituents independently selected from the group consisting of:sulfonic acid or SO.sub.3 H groups and amino groups selected from the group consisting of morpholinyl, pyrrolidinyl, and piperazinyl,with the proviso that when R.sub.2 is alkyl and is substituted, the substituent is not oxygen at the .alpha.-position to the furanone ring.