Patent ID: 6472532
Filing Date: 2002-10-29
Classification: A61P,C07D

Abstract:
A process for the preparation of a compound of formula I: wherein:R1, R2, R3, R6 are, independently, hydrogen or a lower alkyl, R4 is a lower alkyl, hydrogen, or a lower alkoxy, R5 is hydrogen or an alcohol protective group, comprising: (i) reacting a compound of formula II: â€ƒwherein R1, R4, R5 are as defined above, with 1,1â€²-carbonyldiimnidazole; (ii) reacting the mixture resulting from step (i) with a compound of formula â€ƒR3R6NH, wherein R3 and R6 are as defined above, and (iii) reacting the mixture resulting from step (ii) with R2NH2 so that said compound of formula I is produced.