Patent ID: 7790684
Filing Date: 2010-09-07
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A method of inhibiting RANKL-induced osteoclastogenesis in a patient in need thereof, comprising administering to said patient a soluble RANK polypeptide composition comprising a soluble RANK polypeptide, wherein said patient suffers from a condition selected from the group consisting of bone cancer, multiple myeloma, melanoma and breast cancer, the soluble RANK polypeptide comprises amino acids 33-196 of SEQ ID NO:2 and is capable of binding to a RANKL polypeptide that consists of amino acids 1-317 of SEQ ID NO:8, and said composition is administered in an amount sufficient to inhibit RANKL-induced osteoclastogenesis in said patient.