Patent ID: 6020345
Filing Date: 2000-02-01
Classification: A61P,C07D

Abstract:
A compound selected from Pyridin-2-yl-methylamines of formula (I): ##STR70## in which: u represents a hydrogen atom or a methyl radical with the proviso that when u is a methyl radical then v and w each represent a hydrogen atom;v represents a hydrogen atom or a chlorine atom or a methyl radical with the proviso that when v represents a chlorine atom or a methyl radical then u and w each represent a hydrogen atom;w represents a hydrogen atom or a fluorine atom or a methyl radical with the proviso that when w represents a fluorine atom or a methyl radical then u and v each represent a hydrogen atom;x represents a hydrogen atom or a fluorine atom;y represents a chlorine atom or a methyl radical;z represents a hydrogen atom or a fluorine atom or a chlorine atom or a methyl radical;A represents:a hydrogen atom or a fluorine atom or a chlorine atom;a C.sub.1 -C.sub.5 alkyl radical, i.e. a straight or branched chain saturated aliphatic hydrocarbon radical containing 1 to 5 carbon atoms;a fluoroalkyl radicala cyclopropyl or cyclobutyl or cyclopentyl radical;a substituted or unsubstituted 5-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulfur without, more than one oxygen and/or sulfur atom being present in the heterocycle A,the aromatic heterocycles being selected from the group consisting of:furan-2-yl, (O.CH:CH.CH;C--),furan-3-yl, (CH:CH.O.CH:C--),1H-pyrrol-2-yl, (NH.CH:CH.CH:C--),1H-pyrrol-3-yl, (CH:CH.NH.CH:C--),1-methyl-pyrrol-2-yl, N(CCH.sub.3).CH:CHCH:C--),1-methyl-pyrrol-3-yl, (CH:CH.N(C.sub.3).CH:C--) orthiophen-2-yl, (S.CH:CH.CH:C--),thiophen-3-yl, (CH:CH.S.CH:C--),pyrazol-yl, (N:CH.CH:CH.N--),1H-pyrazol-3-yl, (CH:CH.N:C--),1H-pyrazol-4-yl, (CH:N.NH.CH:C--),1-methyl-pyrazol-3-yl, (CH:CH.N(CH.sub.3).N:C--),imidazol-1-yl, (CH:N.CH:CH.N--),1H-imidazol-2-yl, (NH-CH:CH.N:C--),1H-imidazol-4-yl, (N:CH.NH.CH:C--),oxazol-2-yl, (O.CH:CH.N:C--),oxazol-4-yl, (N:CH.O.CH:C--),oxazol-5-yl, (O.CH:N.CH:C--),isoxazol-5-yl, (O.N:CH.CH:C--),isoxazol-4-yl, (CH:N.O.CH:C--),isoxazol-3-yl, (CH:CH.O.N:C--),thiazol-2-yl, (S.CH:CH.N:C--),thiazol-4-yl, (N:CH.S.CH.C--),thiazol-5-yl, (S.CH:N.CH:C--),isothiazol-5-yl, (S.N:CH.CH:C--),isothiazol-4-yl, (CH:N.S.CH:C--),isothiazol-3-yl, (CH:CH.S.SN:C--),[1. 2,4]triazol-1-yl, (CH:N.CH;N.N--),1H-[1,2,4]triazol-3-yl, (N:CH.NH.N:C--),[1,2,4]oxadiazol-3-yl, (N:CH.O.N:C--),[1,2,4]oxadiazol-5-yl, (O.N:CH.N:C--),5-methyl-[1,2,4]oxadiazol-3-yl, (N:C(CH.sub.3).O.N:C--) and1H-tetrazol-5-yl, (NH.N:N.N:C--):an alkoxy (R.sub.1 O) or alkylthio (R.sub.1 S--) group in which the R.sub.1 radical represents:a C.sub.1 -C.sub.5 alkyl radical as defined above,a monofluoromethyl or trifluoromethyl radical,a cyclopropyl or cyclobutyl or cyclopentyl radical;an amino group ##STR71## in which R.sub.2 and R.sub.3, which are identical or different, represent hydrogen, or a C.sub.1 -C.sub.5 alkyl radical as defined above or a cyclopropyl or cyclobutyl radical or a trifluoromethyl radical;a saturated cyclic amino group ##STR72## in which n is 1 or 2; an alkoxycarbonyl group; andan addition salt thereof with a pharmaceutically-acceptable inorganic acid or organic acid.