Patent ID: 6512102
Filing Date: 2003-01-28
Classification: A61K,A61P,C12N

Abstract:
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide variant of the casein kinase I epsilon (CKI&egr;) polypeptide having the sequence set forth in SEQ ID NO:1, wherein said polypeptide variant has an amino acid sequence that differs from the sequence set forth in SEQ ID NO:1 by having a mutation within the kinase region defined by amino acid residues 1-69 of SEQ ID NO:1, wherein said mutation is an amino acid substitution that results in under-phosphorylation of the polypeptide variant by a phosphorylating molecule with respect to phosphorylation of said CKI&egr; polypeptide by said phosphorylating molecule, or wherein said mutation results in under-phosphorylation of a CKI&egr; substrate by said polypeptide variant with respect to phosphorylation of said CKI&egr; substrate by said CKI&egr; polypeptide.