Patent ID: 8350040
Filing Date: 2013-01-08
Classification: A61P,C07D,C07F

Abstract:
1. A process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide as resolution agent, said process comprising: a) reacting a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino) ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol with said resolution agent in a suitable solvent; b) separating the resulting salt of (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol and said resolution agent from the reaction mixture obtained under a); c) optionally recrystallizing or slurry the salt obtained under b) in a suitable solvent; d) liberating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from the salt obtained under b) or c).