Patent ID: 6828317
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound of the following formula I or a pharmaceutically acceptable salt thereof wherein:A is a structure of the following formula i, ii, iii, or iv X is O or S; Y is (a) â€”NHC(&boxH;O)R1, (b) â€”NHC(&boxH;S)R1, (c) â€”NHC(&boxH;NCN)R1, (d) â€”NH-het1, (e) â€”O-het1, (f) â€”S-het1, (g) -het2, or (h) â€”OH; R1 is (a) â€”H (b) â€”NH2, (c) â€”NHC1-4alkyl, (d) â€”C1-4alkyl, (e) â€”C2-4alkenyl, (i) â€”C1-4heteroalkyl, (g) â€”(CH2)mC(&boxH;O)C1-4alkyl, (h) â€”OC1-4alkyl, (i) â€”SC1-4alkyl, (j) â€”(CH2)pC3-6cycloalkyl, (k) â€”(CH2)rC(&boxH;O)aryl, or (l) â€”(CH2)sC(&boxH;O)het1; R2, R3, R7, and R8 are independently (a) â€”H, (b) â€”Cl, (c) â€”F, (d) â€”CH3, (e) â€”NH2, or (f) â€”OH; R4 is (a) â€”H, (b) â€”C1-4alkyl, (c) â€”C1-4heteroalkyl, (d) â€”(CH2)qC(&boxH;O)OC1-4alkyl, (e) â€”(CH2)mC(&boxH;O)C1-4alkyl, (f) -aryl, or (g) -het1; R5 and R6 are independently (a) â€”H, (b) â€”F, (c) â€”C1-4alkyl, (d) â€”C3-6cycloalkyl, (e) â€”C1-4heteroalkyl, (f) -aryl, (g) -het1, (h) â€”OC1-4alkyl, (i) â€”O(C&boxH;O)C1-4alkyl, (j) â€”(C&boxH;O)OC1-4alkyl; or (k) R5 and R6 taken together are C3-6cycloalkyl; n, m, p, q, r and s at each occurrence are independently 0, 1, or 2; het1 at each occurrence is independently a C-linked 5 or 6 membered heterocyclic ring having 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur within the ring; het2 at each occurrence is independently a N-linked 5 or 6 membered heterocyclic ring having 1 to 4 nitrogen and optionally having one oxygen or sulfur within the ring; and wherein at each occurrence the alkyl, alkenyl, and cycloalkyl groups independently are optionally substituted with one, two, or three substituents selected from the group consisting of halo, aryl, het1, and het2.