Patent ID: 9040105
Filing Date: 2015-05-26
Classification: A61K,A61P,Y10S

Abstract:
1. A process for the preparation of nanocrystals or amorphous nanoparticles of an active comprising: i) providing a macrosuspension comprising a dispersion of a micrometer-sized material comprising an active in a solution of a surfactant or a steric stabiliser, wherein the active is in the solid state and remains in the solid state during the process; ii) stirring the macrosuspension for at least 1 minute at a rotational speed above 500 rounds per minute (rpm) using a rotor-stator mixer; and iii) passing the macrosuspension through a jet stream or piston-gap type high pressure homogenizer to produce nanocrystals or amorphous nanoparticles of the active wherein the homogenization in step iii) takes place at a pressure below 1,500 bar applying up to 20 homogenization cycles maximum.