Patent ID: 7985771
Filing Date: 2011-07-26
Classification: A61K,Y10S

Abstract:
1. A method of treatment for a mammal suffering from a dermatologic condition selected from the group consisting of contact dermatitis, acne, rosacea, and psoriasis, comprising administering a therapeutically effective amount of a compound of Formula I: wherein: R R R R X is: —S—; —S(O)—; —S(O) Y is: —S—; —S(O)—; —S(O) or X—R R′ is: hydrogen; alkenyl; optionally substituted alkyl; optionally substituted cycloalkyl; phosphoryl; or optionally substituted aryl; R″ is: hydrogen; alkenyl; optionally substituted alkyl; or optionally substituted aryl; or R′ and R″ together with the atom to which they are attached form a 5- to 7-membered aromatic, saturated or unsaturated ring, optionally incorporating one or more additional heteroatoms chosen from N, O, or S, and optionally substituted with one or more substitutents selected from the group consisting of optionally substituted lower alkyl, halo, cyano, alkylthio, lower alkoxy, carboxy, benzyl, and oxo; R′″ is: hydrogen; alkenyl; optionally substituted alkyl; acyl, optionally substituted cycloalkyl; phosphoryl; or optionally substituted aryl; or a compound of Formula III: wherein: R R or R R or R R R R or R R R