Patent ID: 7307064
Filing Date: 2007-12-11
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating a cardiovascular disease comprising administering to a subject in need thereof an effective amount of a soluble CTLA4 molecule comprising an extracellular domain of a CTLA4 molecule, or portion thereof which binds a B7-1 or B7-2 antigen expressed on activated B cells, wherein the extracellular domain of the CTLA4 molecule comprises the amino acids shown in SEQ ID NO: 17 beginning with methionine at position +1 or with alanine at position −1 and ending with aspartic acid at position 124, wherein the cardiovascular disease is atherosclerosis, and wherein the method does not comprise administering a TNF/TNFR blocking molecule, soluble gp39, soluble CD40, antibodies which bind to CD40, or monoclonal antibodies to gp39.