Patent ID: 6569449
Filing Date: 2003-05-27
Classification: A61K

Abstract:
A method for delivering an effective amount of an opioid antagonist selected from the group consisting of naltrexone, nalbuphine, nalorphine, naloxone, nalmefene, cyclazocine, levallorphan, cyclorphan, oxilorphan and pentazocine comprising transdermally administering an opioid antagonist prodrug selected from the group consisting of naltrexone-R (I), nalbuphine-R,R1 (II), nalorphine-R,R1 (III), naloxone-R (IV), nalmefene-R (V), cyclazocine-R (VI), levallorphan-R (VII), cyclorphan-R (VIII), oxilorphan-R (IX), and pentazocine-R (X),wherein R and R1 are physiologically hydrolyzable and are independently selected from the group consisting of alkylcarbonyl, arylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, phosphate and carbamoyl.