Patent ID: 6521754
Filing Date: 2003-02-18
Classification: A61K,A61P,C07D

Abstract:
A compound of formula IA wherein R1 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, cycloalkyloxy, halogen, hydroxy or trifluoromethylloxy; R2, R3 are independently from each other hydrogen, halogen, lower alkyl or lower alkyloxy; a five or six membered aromatic or non aromatic heterocycle, which may be attached to the benzo group via the linker â€”(O)mâ€”(CH2)n or â€”N=C(CH3)-and is unsubstituted or substituted by one or two group(s) R7, wherein R7 is defined below; Râ€² is (CH2)n-six membered aromatic heterocycle, which rings may be unsubstituted or substituted by 2-oxo-pyrrolidin, piperidinyl, phenyl, â€”(CH2)nOH, halogen, CF3, =O, lower alkyl, cycloalkyl, â€”(CH2)n-O-lower alkyl, â€”(CH2)nNH2, â€”(CH2)nCN, â€”C(O)O-lower alkyl, â€”CH2â€”Oâ€”S(O)2CH3, â€”C(O)-lower alkyl, â€”C(O)â€”(CH2)n-lower alkoxy, â€”CH2â€”N(R6)C6H4F, â€”CH2â€”N(R6)C(O)O-lower alkyl, â€”N(R6)â€”C(O)â€”N(R5)â€”(CH2)nâ€”O-lower alkyl, -or by tetrahydrofuran, substituted by 4-Cl-phenyl, or by piperazin-1-yl, morpholinyl, thiomorpholinyl, thiomorpholin-1-oxo, pyrrolidin-1-yl or by piperidin-1-yl or is benzopiperidin-1-yl or benzothien-2-yl, or X is O or S R5, R6 are independently from each other hydrogen or lower alkyl, R7 is lower alkyl, lower alkoxy, â€”C(O)-lower alkyl, â€”C(O)O-benzyl, â€”C(O)O-lower alkyl, â€”(CH2)nNR5R6, pyridinyl, unsubstituted or substituted by lower alkyl, or is â€”CH2N(R5)â€”C(O)O-lower alkyl, â€”NHâ€”C(phenyl)3, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, unsubstituted or substituted by lower alkyl; n is 0, 1, 2, 3 or 4; m is 0 or 1; o is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.