Patent ID: 6242582
Filing Date: 2001-06-05
Classification: C07D,G01N

Abstract:
A neuraminidase binder, in which the analogue of neuraminic acid is a compound of formula (II): ##STR7##whereinR represents an azido group, an unsubstituted or substituted guanidino group, or an unsubstituted or substituted amino group;R.sup.2 represents COCH.sub.3, COCF.sub.3 OR SO.sub.2 CH.sub.3 ;X represents O or NH;W represents a spacer group made up of a chain of atoms having a total length of between four and one hundred atoms, and optionally also comprising substituted carbon and/or nitrogen atoms and optionally including oxygen and/or sulphur atoms;Y represents OH, SH, NH.sub.2, CH.dbd.O, CH.dbd.CH.sub.2, CO.sub.2 H, CONHNH.sub.2 OR NH-biotinyl, or a protected form of one of these end functionalities;and wherein the substituent on the amino or guanidino group, when present, is a substituted or unsubstituted C.sub.1-6 alkl group, or an amino, hydroxy, cyano or alkoxycarbonyl group;with the proviso that X-W-Y does not include the group OC(.dbd.Z)NR.sup.5 R.sup.6, wherein Z represents O or S, and R.sup.5 and R.sup.6 independently represents H or a hydrocarbon group optionally substituted by NH.sub.2, OH or SH, but R.sup.5 and R.sup.6 are not both H.