Patent ID: 9072879
Filing Date: 2015-07-07
Classification: A61B,A61K,A61M

Abstract:
1. An ultrasound-mediated drug delivery method for administering an amount of AP-1 (Atherosclerotic plaque-specific Peptide-1)-conjugated liposomes to a tumor tissue at least comprising the following steps: providing a high-intensity focused ultrasound apparatus; administering the AP-1-conjugated liposomes to the tumor tissue, wherein AP-1 comprises the amino acid sequence CRKRLDRNC, and can locate the tumor tissue and bind to an IL-4 receptor of liposome; performing a sonication with a frequency of between about 20 kHz to 10 MHz to a blood vessel of the tumor tissue by the high-intensity focused ultrasound apparatus for a period between about 10 seconds to 30 minutes, wherein the sonication is capable of enhancing the permeability of the blood vessel to allow the administration of the AP-1-conjugated liposomes to the tumor tissue; if the AP-1-conjugated liposomes are administered at a dose lower than 3-5 mg/kg, then after the step of performing the sonication to the blood vessel, the step of administering the AP-1-conjugated liposomes is repeated with the lower dose to the tumor tissue, and then another sonication to the blood vessel of the tumor tissue is performed by the high-intensity focused ultrasound apparatus for the period; and if the AP-1-conjugated liposomes are administered at a dose higher than 10-15 mg/kg, then after the step of performing the sonication to the blood vessel, further method steps are delayed for between 1 minute and 6 hours, and then another sonication to the blood vessel of the tumor tissue is performed by the high-intensity focused ultrasound apparatus for the period.