Patent ID: 8188274
Filing Date: 2012-05-29
Classification: C07D

Abstract:
1. A process for preparing a compound of general formula R R R R R R comprising the following process steps: a) reacting 7-chloro-6-nitro-3H-quinazolin-4-one with a primary amine of formula R b) converting the resulting compound of general formula into the sulphonyl derivative of formula wherein R a phenyl group optionally substituted by one to three substituents selected from C c) converting the sulphonyl derivative of formula (XIII) into a compound of formula by reacting with an alcohol of formula R wherein R d) reducing the compound of formulae (XI) thus obtained to the amino derivative of formula wherein R e) converting the amino derivatives of formula (XII) into the phosphonic ester of formula wherein R f) reacting the resulting phosphonic ester of formula (III) with a hydrogen sulphite adduct of formula wherein M+ denotes a cation, and R R R