Patent ID: 7005256
Filing Date: 2006-02-28
Classification: C12Q

Abstract:
1. A method of identifying a gene or genes involved in transcription-dependent memory comprising the steps of: (a) training non-human animals to induce transcription-dependent memory formation in said animals; (b) extracting total RNA from brain tissue of said animals trained in step (a); (c) synthesizing labeled cDNA probes complementary to the RNA extracted in step (b); (d) hybridizing the cDNA probes synthesized in step (c) to microarray chips containing DNA sequences from genes of the genome of said non-human animals under conditions appropriate for hybridization of the cDNA probes to complementary DNA sequences on the microarray chips, wherein a signal is produced from said labeled cDNA probes upon hybridization to complementary DNA sequences; (e) detecting the signal produced in step (d); and (f) performing a statistical comparison between the signal detected in step (e) and a signal detected in a control for each gene, wherein said control is obtained according to a method comprising the steps of: