Patent ID: 7691811
Filing Date: 2010-04-06
Classification: A61K,A61P

Abstract:
1. A method for alleviating dry eye in a warm-blooded animal exhibiting same, said method comprising administering to the eye or eyes of said animal a composition comprising: (a) loteprednol etabonate; and (b) a compound having the formula: wherein: Z R Y is —OH or —OCOR and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated; the compound of formula (II) being selected from the group consisting of hydrocortisone, hydrocortisone acetate, prednisolone, prednisolone acetate, corticosterone, corticosterone 21-acetate, 11 deoxycorticosterone and 11-deoxyhydrocortisone; in a combined synergistic anti-inflammatory effective amount; the amount of compound of formula (II) being sufficient to enhance the anti-inflammatory activity or duration of action, or both, loteprednol etabonate, said amount of said compound of formula (II) being insufficient alone to have anti-inflammatory activity; wherein the molar ratio of the compound of formula (II) to loteprednol etabonate is from about 2:1 to about 0.05:1; with the proviso that the composition excludes any compound having the formula: wherein: R is H or C Z X R and the dotted line is defined as above; with the proviso that when R is C