Patent ID: 6900177
Filing Date: 2005-05-31
Classification: A61K,A61P,C07K

Abstract:
1. An ApoA-I agonist compound comprising: (i) a 15 to 26-residue peptide or peptide analogue according to formula (I) which forms an amphipathic α-helix in the presence of lipids and exhibits at least about 38% LCAT activation activity as compared with human ApoA-I wherein one or two helical turns are deleted from formula (I), wherein a helical turn consists of 3 to 4 consecutive residues selected from residues X or a pharmaceutically acceptable salt thereof, wherein: X X X X X X X X X X X X X X X X X X X X X X X Z Z each R is independently —H, (C each “-” between residues X an N-terminally blocked form, a C-terminally blocked form, or an N- and C-terminally blocked form of formula (I).