Patent ID: 6596880
Filing Date: 2003-07-22
Classification: C07D,Y02P

Abstract:
Method for preparing a taxane derivative of the formula: in which Ar represents an aryl radical, R represents a hydrogen atom or the acetyl radical and R1 represents a benzoyl or tert-butoxycarbonyl radical, comprising esterification of a derivative of baccatine III or of 10-deacetyl baccatine III of the formula: in which G1 represents a protecting group for the hydroxyl function and G2 represents the acetyl radical or a protecting group for the hydroxyl function, using an acid of the formula: in which Ar and R1 are defined as above and R2 represents a protecting group for the hydroxyl function, followed by replacement, by hydrogen atoms, of the protecting groups G1, G2 and R2 of the product obtained, and wherein the esterification is carried out at a temperature ranging from âˆ’10 to less than 60Â° C.