Patent ID: 8455689
Filing Date: 2013-06-04
Classification: C07C

Abstract:
1. A process for preparing a substituted biphenylanilide of formula (I), wherein X is hydrogen, fluorine or chlorine; R R R R n is 1, 2 or 3, where in case that n is 2 or 3, the R which comprises reacting a compound of formula (II) in which Hal is halogen and X is as defined above, in the presence of a base and a palladium catalyst selected from the group consisting of: a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand, and c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine; in a solvent, with an organoboron compound of formula (III) selected from the group consisting of: (i) a boronic acid of formula (III) wherein m is 2, each Q is a hydroxyl-group, R or the anhydrides, dimers or trimers formed thereof; (ii) a boronic acid derivative of formula (III), wherein m is 2, p is 1, each Q is independently selected from the group consisting of F, Cl, Br, I, C R (iii) a bonnie acid of formula (III), wherein m is 1, p is 2, Q is selected from the group consisting of OH, F, Cl, Br, I, C R (iv) a cyclic boronic acid ester of formula (III), wherein m is 2, p is 1, each Q is independently C R (v) a boronate of formula (III) wherein m is 3, p is 1, R each Q is independently selected from the group consisting of OH, F, Cl, Br, I, C and wherein the negative charge of the boronate anion is compensated by a cation; (vi) a triarylborane of formula (III), wherein m is 0, p is 3, R (vii) a tetraarylborate of formula (III), wherein m is 0, p is 4, R and wherein the negative charge of the boronate anion is compensated by a cation; and where the triarylphosphines or trialkylphosphines used may optionally be substituted.