Patent ID: 6090841
Filing Date: 2000-07-18
Classification: C07D

Abstract:
A compound having the formula I: ##STR7## or a pharmaceutically acceptable salt thereof wherein: X is 1) --C(O)OR.sup.d,2) --P(O)(OR.sup.d)(OR.sup.e)3) --P(O)(R.sup.d)(OR.sup.e)4) --S(O).sub.m OR.sup.d,5) --C(O)NR.sup.d R.sup.h,Y is 1) --C(O)--,2) --O--C(O)--,3) --NR.sup.e --C(O)--,4) --S(O).sub.2 --,5) --P(O)(OR.sup.4) or6) C(O)C(O);Z is 1) a bond, or2) --C(R.sup.8)(R.sup.9)--;R.sup.1 is 1) C.sub.1-10 alkyl,2) C.sub.2-10 alkenyl,3) C.sub.2-10 alkynyl,4) Cy,5) Cy-C.sub.1-10 alkyl,6) Cy-C.sub.2-10 alkenyl,7) Cy-C.sub.2-10 alkynyl,wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.2 is 1) hydrogen,2) C.sub.1-10 alkyl,3) Cy,4) Cy-C.sub.1-10 alkyl,wherein alkyl is optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.3 is 1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy-(Cy).sub.p,6) Cy-(Cy).sub.p -C.sub.1-10 alkenyl,7) Cy-(Cy).sub.p -C.sub.2-10 alkenyl,8) Cy-(Cy).sub.p -C.sub.2-10 alkynyl,alkyl, allenyl and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.4 is 1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy,6) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from R.sup.a, and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.5, R.sup.6, and R.sup.7 are each independently1) hydrogen, or2) a group selected from R.sup.b ; orR.sup.5 and R.sup.6 or R.sup.6 and R.sup.7 and the two adjacent carbon atoms to which they are attached, together form a 5-7 membered saturated or unsaturated monocyclic ring containing zero heteroatoms;R.sup.8 is 1) hydrogen,2) a group selected from R.sup.a, or3) a group selected from R.sup.1 ;R.sup.9 is 1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy,6) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from R.sup.a, and Cy is optionally substituted with one to four substituents independently selected from R.sup.b,R.sup.a is 1) --CF.sub.3 ;2) --OR.sup.d,3) --NO.sub.2,4) halogen5) --S(O).sub.m R.sup.d,6) --SR.sup.d,7) --S(O).sub.2 OR.sup.d,8) --S(O).sub.m NR.sup.d R.sup.e,9) --NR.sup.d R.sup.e,10) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,11) --C(O)R.sup.d,12) --CO.sub.2 R.sup.d,13) --CO.sub.2 (CR.sup.f R.sup.g).sub.n CONR.sup.d R.sup.e,14) --OC(O)R.sup.d,15) --CN,16) --C(O)NR.sup.d R.sup.e,17) --NR.sup.d C(O)R.sup.e,18) --OC(O)NR.sup.d R.sup.e,19) --NR.sup.d C(O)OR.sup.e, or20) --NR.sup.d C(O)NR.sup.d R.sup.e ;21) --CR.sup.d (N--OR.sup.e), or22) Cy optionally substituted with a group independently selected from R.sup.c ;R.sup.b is 1) a group selected from R.sup.a,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl, or5) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl, and Cy are optionally substituted with a group independently selected from R.sup.c ;substituted with a group independently selected from R.sup.c ;R.sup.c is 1) halogen,2) amino,3) carboxy,4) C.sub.1-4 alkyl,5) C.sub.1-4 alkoxy,6) aryl,7) aryl C.sub.1-4 alkyl, or8) aryloxy;R.sup.d and R.sup.e are independently selected from the group consisting of1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkaynyl,5) Cy, and6) Cy C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R.sup.c ; orR.sup.d and R.sup.e together with the atoms to which they are attached form and;R.sup.f and R.sup.g are independently selected from hydrogen, C.sub.1-10 alkyl, Cy and Cy C.sub.1-10 alkyl; orR.sup.f and R.sup.g together with the carbon to which they are attached form a ring of 5 to 7 members containing 0 heteroatoms;R.sup.h is 1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) cyano,6) aryl,7) aryl C.sub.1-10 alkyl, or10) --SO.sub.2 R.sup.i ;wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and aryl is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.i is 1) C.sub.1-10 alkyl,2) C.sub.2-10 alkenyl,3) C.sub.2-10 alkynyl, or4) aryl;wherein alkyl, alkenyl, alkynyl and aryl are each optionally substituted with one to four substituents independently selected from R.sup.c ;Cy is cycloalkyl and aryl;m is an integer from 1 to 2;n is an integer from 1 to 10; andp is 0 or 1.