Patent ID: 8834892
Filing Date: 2014-09-16
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A reassortant influenza virus comprising genes encoding PA, PB1, PB2, NP (nucleocapsid protein), M (matrix protein) and NS1 (nonstructural protein 1), and genes encoding HA (hemagglutinin) and NA (neuraminidase); wherein amino acids 431 to 434 of NP having the sequence of SEQ ID NO: 4 or amino acids 101 to 104 of NS1 having the sequence of SEQ ID NO: 7 is substituted with a caspase recognition sequence selected from the group consisting of DEVD, AEVD, IETD, WEHD, and YVAD (SEQ ID NO: 11 to SEQ ID NO: 15, respectively).