Patent ID: 6316415
Filing Date: 2001-11-13
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound of Formula I ##STR22##wherein R.sup.1 is ##STR23##R.sup.3 is hydrogen,C.sub.1 -C.sub.6 alkyl,--(CH.sub.2).sub.n aryl, or--(CH.sub.2).sub.n heteroaryl;R.sup.4 is C.sub.1 -C.sub.6 alkyl,--(CH.sub.2).sub.n aryl, or--(CH.sub.2).sub.n heteroaryl;R.sup.5 and R.sup.6 are each independently hydrogen,C.sub.1 -C.sub.6 alkyl,--(CH.sub.2).sub.n aryl, or--(CH.sub.2).sub.n heteroaryl;R.sup.7 is C.sub.1 -C.sub.6 alkyl,--(CH.sub.2).sub.n aryl, or--(CH.sub.2).sub.n heteroaryl;each n is independently 0 to 6;each m is independently 0, 1, 2, or 3;A is alanine, leucine, isoleucine, proline, phenylalanine, glycine, tyrosine, serine, threonine, tryptophan, cysteine, methionine, valine, asparagine, glutamine, aspartic acid, lysine, glutamic acid, arginine, or histidine;R.sup.2 is --(CH.sub.2)n--Z; andZ is aryl, heteroaryl, cycloalkyl, C.sub.1 -C.sub.6 alkyl, ##STR24## ##STR25## ##STR26##wherein each R.sup.Q is independently hydrogen or C.sub.1 -C.sub.6 alkyl, and each p is independently 1, 2 or 3, fluorenyl, substituted flourenyl, substituted aryl, substituted heteroaryl, or substituted cycloalkyl, and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.