Patent ID: 6514996
Filing Date: 2003-02-04
Classification: C07D

Abstract:
An oxygen-containing heterocyclic compound represented by Formula (I): whereinR1 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, lower alkenyl, C4-10 cycloalkenyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, aralkyl, cyano, or â€”(CH2)nâ€”E1â€”COG1 (wherein n is an integer of 0 to 4; E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, aralkyl, OR6 (wherein R6 represents hydrogen, lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, or aralkyl), or NR7R8 (wherein R7 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; and R8 represents substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; or R7 and R8 are combined to represent a substituted or unsubstituted heterocyclic group containing at least one nitrogen atom)); R2 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, lower alkenyl, C4-10 cycloalkenyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, aralkyl, cyano, or â€”(CH2)qâ€”E4â€”COG4 (wherein q is an integer of 0 to 4; E4 represents a bond, O, or NH; and G4 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, aralkyl, OR6 (wherein R6 represents hydrogen, lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, or aralkyl), or NR7R8 (wherein R7 represents hydrogen, substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; and R8 represents substituted or unsubstituted lower alkyl, C3-10 cycloalkyl, C4-12 polycycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroarylalkyl; or R7 and R8 are combined to represent a substituted or unsubstituted heterocyclic group containing at least one nitrogen atom)); or R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; R3 represents hydrogen, phenyl, or halogen; R4 represents substituted or unsubstituted lower alkoxy; A represents O; B represents O; D represents â€”CONHâ€”, â€”CH2CH2â€”, â€”CH&boxH;CHâ€”, â€”CH(C6H5)CH2â€”, â€”C(C6H5)&boxH;CHâ€” or â€”COCH2â€”; and R5 represents substituted or unsubstituted pyridyl, or a pharmaceutically acceptable salt thereof.