Patent ID: 8759519
Filing Date: 2014-06-24
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of formula (XVIII) comprising a) reacting an intermediate of formula (VIII) with an intermediate of formula (XI) in the presence of a suitable solvent to produce an intermediate of formula (I), b) reacting the intermediate of formula (I) with an intermediate of formula (II) in a suitable solvent followed by reduction and salt formation to produce an intermediate of formula (XIII), c) converting the intermediate of formula (XIII) by base neutralization, basic hydrolysis and acidification with hydrochloric acid to produce an intermediate of formula (XVII) and d) reacting the intermediate of formula (XVII) with O-(tetrahydro-2H-pyran-2-yl)-hydroxylamine, in the presence of an appropriate coupling reagent