Patent ID: 9091690
Filing Date: 2015-07-28
Classification: G01N

Abstract:
1. A method of detecting a renal cancer selected from the group consisting of a clear cell carcinoma, a papillary carcinoma and a combination thereof in a subject, the method comprising: providing a urine sample from a subject suspected of having a renal cancer selected from the group consisting of a clear cell carcinoma, a papillary carcinoma and a combination thereof; contacting the urine sample with at least one antibody that binds aquaporin-1 (AQP1), under conditions sufficient for formation of a primary complex comprising the at least one antibody and the AQP1 if present; measuring quantity of the primary complex; comparing the quantity of the primary complex to that of a control complex formed from the at least one antibody and a urine sample of an individual who does not have a renal cancer selected from the group consisting of a clear cell carcinoma, a papillary carcinoma and a combination thereof; and detecting a renal cancer selected from the group consisting of a clear cell carcinoma, a papillary carcinoma and a combination thereof in the subject if the primary complex comprises the AQP1 at a statistically significant elevated level compared to the control complex.