Patent ID: 6200602
Filing Date: 2001-03-13
Classification: A61K

Abstract:
A drug deliver composition for colonic delivery comprising(a) a polar drug;(b) an absorption promoter comprising a mixture of(i) a dispersing agent, and(ii) a substance selected from the group consisting of fatty acids having 6 to 16 carbon atoms, salts of fatty acids having 6 to 16 carbon atoms, and mono/diglycerides of fatty acids having fatty acids with carbon chains of 6 to 16 carbon atoms; and(c) a means provided to prevent release of the polar drug and absorption promoter until the composition reaches the terminal ileum or the colon following oral administration,wherein the means is a formulation selected from the group consisting of capsules, tablets, and pellets, coated with a material having a thickness between about 80 .mu.m and 300 .mu.m which is dissolved by the conditions found in the intestines.