Patent ID: 8110372
Filing Date: 2012-02-07
Classification: C07H,C07K

Abstract:
1. A method of detecting, in a test sample, the presence of a modulator of zalpha11 polypeptide activity, the method comprising: (a) culturing a cell into which has been introduced an expression vector comprising the following operably linked elements: (b) comparing levels of activity of the polypeptide in the presence and absence of a test sample, by a biological or biochemical assay, wherein the biological or biochemical assay comprises the zalpha11 polypeptide exhibiting cell proliferation activity or signal transduction activity when exposed to activated CD3+ selected human T-cell conditioned media, thereby detecting the presence of the modulator of zalpha11 polypeptide activity; and (c) determining from the comparison the presence of the modulator of zalpha11 polypeptide activity in the test sample.