Patent ID: 7838302
Filing Date: 2010-11-23
Classification: C09K,G01N,G02B

Abstract:
1. A photoswitchable imaging composition, comprising: a light-emitting molecular entity, capable of being switched between a first state able to emit light at a first, emission wavelength upon excitation and a second state that does not substantially emit light at the first wavelength upon excitation, wherein the light-emitting entity comprises a first portion that is capable of emitting light at the first wavelength upon excitation when the light-emitting entity is in the first state, and a second portion that activates the first portion upon exposure to an external stimulus, thereby placing the light-emitting entity in the first state, wherein the first portion is Cy5, Cy5.5, Cy7, Alexa Fluor 647, Alexa Fluor 680, Alexa Fluor 700, Alexa Fluor 750, Alexa Fluor 790, DiD, DiR, YOYO-3, YO-PRO-3, TOTO-3, or TO-PRO-3, and wherein the second portion is Alexa Fluor 405, Cy2, Alexa Fluor 488, Cy3, Cy3B, or Cy3.5, and wherein the first portion and the second portion are each bonded to a common antibody and are not bonded directly to each other.