Patent ID: 7199241
Filing Date: 2007-04-03
Classification: C07D

Abstract:
1. Chromatographic process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide, by enantiomeric resolution of 2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide, which process comprises using a system comprising series of fixed-bed columns connected in series, wherein the charge (solution of the compounds to be separated) and the eluent are injected continuously into the system while the separated compounds are removed continuously in the extract (compound most strongly retained) and the raffinate (compound least strongly retained), wherein the system comprises at least six columns filled with chiral stationary phase.