Patent ID: 6217871
Filing Date: 2001-04-17
Classification: A61K,C07K,C12Q,Y10S

Abstract:
An isolated peptide consisting of a subsequence of a Class II major histocompatibility molecule, wherein the peptide has the following properties,(a) having a structure comprising R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 -R.sub.5 -R.sub.6 -R.sub.7 -R.sub.8 -R.sub.9 -R.sub.10 -R.sub.11 -R.sub.12 -R.sub.13 -R.sub.14 -R.sub.15 -R.sub.16,wherein R.sub.1 is Gln, Lys, or Arg; R.sub.2 is Arg; R.sub.3 and R.sub.4 are members independently selected from the group consisting of all amino acids; R.sub.5 is Ala, Glu, Asp, Val, Leu or Ile; R.sub.6 and R.sub.7 are members independently selected from the group consisting of all amino acids; R.sub.8 is Thr; R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, and R.sub.15 are members independently selected from the group consisting of all amino acids; and, R.sub.16 is Val;(b) capable of generating an immune response to a non-Hodgkin's B cell lymphoma cell.