Patent ID: 8728808
Filing Date: 2014-05-20
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A multiple inducible gene modulation system comprising two individually operable heterologous gene modulation systems, wherein each individually operable heterologous gene modulation system comprises: a) a first gene expression cassette comprising a polynucleotide sequence that encodes a polypeptide comprising: b) a second gene expression cassette comprising a polynucleotide sequence comprising a promoter operably linked to a polynucleotide sequence that encodes a second polypeptide comprising a nuclear receptor ligand binding domain and a transactivation domain; and wherein each individually operable heterologous gene modulation system is orthogonal to the other individually operable heterologous gene modulation system present in the multiple inducible gene modulation system.