Patent ID: 6891043
Filing Date: 2005-05-10
Classification: A61K,A61P

Abstract:
1. An inhibitor of fatty acid amide hydrolase represented by the following formula: wherein: A is an α-keto heterocyclic pharmacophore for inhibiting the fatty acid amide hydrolase; B is a chain for linking A and C, said chain having a linear skeleton with a length of between 3 and 9 sequential atoms selected from the group consisting of carbon, oxygen, and sulfur, said linear skeleton being a linear alkyl diradical, optionally including one or more ether oxygens, and optionally including one or more thio ether sulfurs, the linear skeleton having a first end and a second end, the first end being covalently bonded to the α-keto group of A, with the following proviso: C is an activity enhancer for enhancing the inhibition activity of said α-keto heterocyclic pharmacophore, said activity enhancer having at least one π-unsaturation situated within a π-bond containing radical selected from a group consisting of aryl, alkenyl, alkynyl, and ring structures having at least one unsaturation, with or without one or more heteroatoms, said activity enhancer being covalently bonded to the second end of the linear skeleton of B, no π-unsaturation within the π-bond containing radical being separated from the α-keto group of A by a sequence of less than 3 atoms bonded sequentially to one another, inclusive of said linear skeleton, at least one π-unsaturation within the π-bond containing radical being separated from the α-keto group of A by a sequence of no more than 9 atoms bonded sequentially to one another, inclusive of said linear skeleton; wherein A is represented by the formula:  wherein “het” is selected from the following group: