Patent ID: 6818660
Filing Date: 2004-11-16
Classification: A61K,C07C,C07D

Abstract:
A compound having the chemical formula: wherein R1 is selected from the group consisting of: heteroaryl and heterocycloalk; R2 is selected from the group consisting of: lower alk, cycloalk, alkoxy, H, OH, &boxH;O, C(O)OH, C(O)O-lower alk, C(O)NH-lower alk, C(O)N(lower alk)2, SH, S-lower alk, NH2, NH-lower alk, and N(lower alk)2, R3 and R4 is each independently lower alk or together cyclopropyl; R5 is either an optionally substituted naphthyl having one to four substituents independently selected from the group consisting of methyl, ethyl, isopropyl, methoxy, Cl, F, Br, and lower haloalkoxy, or a substituted phenyl having one to four substituents with at least one substituent in a meta or para position selected from the group consisting of: lower alkyl, methoxy, Cl, F, Br, and lower haloalkoxy, provided that said substituted phenyl may also have 2 to 3 additional substituents; R6 if present is either hydrogen, lower alkyl or lower alkenyl, wherein R6 is not present if R2 is &boxH;O; Y1 is either covalent bond, alkylene, or alkenylene; Y2 is alkylene; Y3 is alkylene; Z is selected from the group consisting of: covalent bond, O, S, NH, N-lower alk, alkylene, alkenylene, and alkynylene, provided that R1 is not pyridyl, benzydioxy, or thiophene; provided that if Z is either O, S, NH, or N-lower alk, then Y1 is not a covalent bond; further provided that Y1 and Z may together be a covalent bond; further provided that if R5 is 3, 4 dimethoxy-phenyl, then R1 is not 4-benzo(d)isothiazole; further provided that if R5 is 4-methoxy-phenyl, then R1 is not 4-benzo(d)isothiazole; further provided that if R5 is 4-Cl-phenyl, then R1 is not pyridyl; 1-imidazole; or 4-benzo(d)isothiazole; and pharmaceutically acceptable salts and complexes thereof; wherein said compound has an IC50&lE;10 &mgr;M using the Calcium Receptor Inhibitor Assay.