Patent ID: 7514553
Filing Date: 2009-04-07
Classification: C07D,Y02P

Abstract:
1. A process for preparing a penicillanic acid compound of formula (2) comprising reacting a halogenated penicillanic acid compound of formula (1), (a) in the presence of a metal bismuth or bismuth compound, and at least one reaction promoter, selected from among alkali metal halide, alkaline earth metal halide, ammonium halide, alkyl ammonium salt, mineral acid, organic carboxylic acid and organic sulfonic acid, (b) with a metal having a lower standard oxidation-reduction potential than bismuth to obtain compound (2) (X and Y are a hydrogen atom or halogen atom, provided that X and Y are not hydrogen atoms at the same time, n is an integer of 0 to 2, and R is a carboxylic acid protecting group) (n and R are the same as above).