Patent ID: 7172859
Filing Date: 2007-02-06
Classification: G01N

Abstract:
1. A method of measuring tissue baffler transfer of a sample, comprising: preparing an array of samples, each sample comprising an active component and at least one additional component, wherein each sample differs from at least one other sample with respect to at least one of the identity of the active component, the identity of the additional components, the ratio of the active component to the additional component, or the physical state of the active component; loading said array of samples onto a lower substrate plate that supports said samples; overlaying the array of samples with a tissue specimen; securing an upper reservoir plate to a side of the tissue specimen opposite the array of samples, the reservoir plate having an array of reservoirs corresponding to the array of samples; filling the array of reservoirs with a reservoir medium; and measuring concentration of one or more sample components in each reservoir of said upper reservoir plate to determine transfer of said sample components from each sample across the tissue specimen; wherein: (a) each sample in the array of samples is a solid source sample or a liquid source sample; (b) the active component is a pharmaceutical, a dietary supplement, a nutraceutical or an alternative medicine; (c) the additional component is an excipient, a solvent, an adhesive, an enhancer, an additive, or a combination thereof; (d) the additional component is an adhesive selected from a polyisobutylene, a silicone, or an acrylic adhesive; (e) the method further comprises the step of detecting an inhomogeneous segment; and correcting for an inhomogeneous segment, wherein the correcting step comprises any of: removing the inhomogeneous segment; ignoring concentration measurement associated with the inhomogeneous segment; adjusting concentration measurements to correct for the inhomogeneous segment; or repairing the inhomogeneous segment; or (f) wherein the tissue specimen is skin tissue.