Patent ID: 6436949
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
A benzamide of formula Ior a tautomeric or isomeric form thereof, or its physiologically tolerated salt,whereinR1 is hydrogen, C1-C6-alkyl, Oâ€”C1-C6-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, â€”NHCOâ€”C1-C4-alkyl, â€”NHCO-phenyl, â€”CONHR8, NHSO2â€”C1-C4-alkyl, â€”NHSO2-phenyl, â€”SO2â€”C1-C4-alkyl or â€”SO2-phenyl, R2 is hydrogen, C1-C6-alkyl, Oâ€”C1-C6-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, â€”NHCOâ€”C1-C4-alkyl, â€”NHCO-phenyl, â€”CONHR8, NHSO2â€”C1-C4-alkyl, â€”NHSO2-phenyl, â€”SO2â€”C1-C4-alkyl or â€”SO2-phenyl or R1 and R2 are, together, a chain â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, which can additionally carry one or two substituents R6, R3 is hydrogen, chlorine, bromine, fluorine, C1-C6-alkyl, phenyl, NHCOâ€”C1-C4-alkyl, NO2 or NH2, R4 C1-C6-alkyl, which can additionally carry a phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indolyl, pyridyl or naphthyl ring which, for its part, is substituted by one or two radicals R7, with R7 being hydrogen, C1-C4-alkyl, â€”Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, â€”CONHR8, â€”NHCOâ€”C1-C4-alkyl, â€”NHCO-phenyl, â€”NHSO2â€”C1-C4-alkyl, â€”NHSO2-phenyl, â€”SO2â€”C1-C4-alkyl or â€”SO2-phenyl, R5 is hydrogen, â€”COâ€”OR8, â€”COâ€”NR9R10, R6 is hydrogen, C1-C6-alkyl, â€”Oâ€”C1-C6-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, R8 is hydrogen or C1-C6-alkyl, R9 is hydrogen, C1-C6-alkyl which can additionally be substituted by a phenyl ring which can additionally carry a radical R11 and can be substituted by R10 is hydrogen or C1-C6-alkyl, R11 is hydrogen, C1-C6-alkyl, â€”Oâ€”C114 C6-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, R12 is hydrogen or a â€”C0-4-alkyl chain which can be substituted by a phenyl ring which can itself additionally carry one or two radicals R11, X is â€”CH2â€”CH2â€”, â€”CH&boxH;CHâ€”, â€”SO2â€”, â€”CH2â€”, â€”COâ€” or â€”CH2â€”COâ€”, n is the number 0, 1 or 2, and m is the number 0, 1 or 2.