Patent ID: 6472208
Filing Date: 2002-10-29
Classification: A61K,C07K

Abstract:
A process for producing ex vivo natural interferon &agr; (nIFN-&agr;), said method comprising the steps of:a) expanding under suitable conditions hematopoietic stem cells (HSCs) in culture; b) priming said HSCs for nIFN-&agr; secretion by incubating said HSCs in IFN-&agr;; c) infecting said hematopoietic stem cells (HSCs) in culture medium with Sendai virus; and d) culturing the HSCs of step c) for a time sufficient for said HSCs to produce natural IFN-&agr;, wherein said HSCs produce more natural IFN-&agr; when expanded according to step a), than HSCs that have not been expanded.