Patent ID: 8927016
Filing Date: 2015-01-06
Classification: A61K,A61P,F26B

Abstract:
1. A method for preventing scattering of a sustained-release microcapsule preparation in the production of a solid sustained-release microcapsule preparation, which comprises 1) preparing the sustained-release microcapsule preparation by an aqueous drying method, 2) dispensing water in a freeze-drying container and freezing it to form an ice layer, 3) dispensing a water suspension of the sustained-release microcapsule preparation in the freeze-drying container to form a frozen layer, and 4) freeze-drying the water suspension in the freeze-drying container comprising an inner face that is partially or wholly coated with an ice layer, so as to prevent scattering of the sustained-release microcapsule preparation, wherein said sustained-release microcapsule preparation contains a drug and a lactic acid-glycolic acid polymer, and wherein the water suspension comprises mannitol.