Patent ID: 6620835
Filing Date: 2003-09-16
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating atherosclerotic plaque rupture, the method comprising administering to a patient having an atherosclerotic plaque at risk for rupture a therapeutically effective amount of a compound of Formula I wherein M is a natural (L) alpha amino acid derivative having the structure X is O, S, S(O)n, CH2, CO, or NRQ; RQ is hydrogen, C1-C6 alkyl, or â€”C1-C6 alkyl-phenyl; R is a side chain of a natural alpha amino acid; R1 is C1-C5 alkoxy, hydroxy, or â€”NHOR5; R2 and R4 are independently hydrogen, â€”C1-C5 alkyl, phenyl â€”NO2, halogen, â€”OR5, â€”CN, â€”CO2R5, â€”SO3R5, â€”CHO, â€”COR5, â€”CONR5R6, â€”(CH2)nNR5R6, â€”CF3, or â€”NHCOR5; each R5 and R6 are independently hydrogen or C1-C5 alkyl; and n is 0 to 2, and the pharmaceutically acceptable salts, esters, and amides thereof, wherein the esters thereof are selected from C1-C6 alkyl esters, C5-C7 cycloalkyl esters, and arylalkyl esters and the amides thereof are derived from ammonia, primary C1-C6 alkyl amines, secondary C1-C6 dialkyl, and 5- and 6-membered heterocyclic amines containing one nitrogen atom; and wherein the group S(&boxH;O)2M is optionally bonded to the 1-, 2- , or 3-position of Formula I.