Patent ID: 9150598
Filing Date: 2015-10-06
Classification: A61K,C07F,G01N

Abstract:
1. A method of making a lipid bilayer comprising: a) providing a device comprising a substrate defining at least one aperture; b) providing a first solution on one side of the aperture; c) providing a second solution on the opposite side of the aperture from the first solution, wherein the first solution is immiscible in the second solution; d) providing a first amphiphilic molecule in the first solution, or second solution, or in both the first solution and second solution; e) contacting the first solution and the second solution through the aperture, thereby forming a first amphiphilic molecule monolayer; f) providing a fourth solution; g) providing a second amphiphilic molecule in the second solution, or fourth solution, or in both the second solution and fourth solution; h) submerging at least a portion of the fourth solution in the second solution, wherein the fourth solution is immiscible in the second solution, thereby forming a second amphiphilic molecule monolayer; and i) contacting the second amphiphilic molecule monolayer and the first amphiphilic molecule monolayer, thereby forming an amphiphilic molecule bilayer.