Patent ID: 6248787
Filing Date: 2001-06-19
Classification: A61K,A61P,C07C,Y10S

Abstract:
A method for ameliorating cachexia in a subject in need of such amelioration which comprises administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salts thereof, said compound having either one of the formula: ##STR5##wherein:X.sub.2 is GhyCH--, GhyCCH.sub.3 -- or H--;X.sub.1, X .sub.1, and X'.sub.2, independently are GhyCH-- or GhyCCH.sub.3 --;Z is --NH(CO)NH--, or --A--(CH.sub.2).sub.n --A--, n is 2-10, which is unsubstituted, mono-- or di-C-methyl substituted, or a mono-- or di-unsaturated derivative thereof, andA is, independently, --(CO)NH--, --NH(CO)--, --NH(CO)NH--, --NH-- or --O--; or ##STR6##wherein:X.sub.3, X.sub.4 and X.sub.5, independently are GhyCH-- or GhyCCH.sub.3 --;X'.sub.3, X'.sub.4 and X'.sub.5, independently are H, GhyCH-- or GhyCCH.sub.3 --;Y is (C.sub.6 H.sub.3), when m.sub.1, m.sub.2, m.sub.3 are 0, or Y is N, when, independently, m.sub.1, m.sub.2, m.sub.3 are 2-6; andA is, independently, --(CO)NH--, --NH(CO)--, --NH(CO)NH--, --NH-- or --O--.