Patent ID: 6673623
Filing Date: 2004-01-06
Classification: G01N,Y10S

Abstract:
An assay for identifying a candidate compound which can modify the lipogenic action of a lipogenin selected from the group consisting of ECM-1, NP-I, TIMP-2 and H2A, said assay comprising;(a) obtaining the candidate compound; (b) obtaining lipogenic molecules of ECM-1, NP-I, TIMP-2 or H2A or a portion thereof; (c) treating target cells by contacting the treated cells wherein said cells are responsive to lipogenic induction, with the compound and the lipogenic molecules; and (d) determining if the compound interferes with the lipogenic action of the lipogenins by detecting whether fat droplets form in the target cells, and in what amounts the droplets form relative to control cells that are not treated with the candidate compound.