Patent ID: 7368591
Filing Date: 2008-05-06
Classification: C07B,C07C

Abstract:
1. A method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form: wherein: Y is —C(═O)X wherein X is —OR R1, R1 R5 is alkyl, cycloalkyl, aralkyl, alkaryl, or aryl; R6 and R7 are each independently H, (C1-C6) alkyl, or hydroxy(C1-C6)alkyl; R8 is H, alkyl, cycloalkyl, aralkyl, alkaryl, or aryl; n is 1, 2 or 3; and m is 1, 2, 3, or 4; comprising the steps of: a) contacting a pro-chiral sulphide of formula (II): wherein R1, R2, R1 with a metal chiral ligand complex, a base, and an oxidizing agent in an organic solvent, for a time and under conditions effective to produce the sulphoxide of formula I; and optionally b) isolating the sulphoxide of formula (I); wherein said metal chiral ligand complex is selected from the group consisting of C