Patent ID: 7563769
Filing Date: 2009-07-21
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A variant of FGF-2 having at least one amino acid substitution in the beta 8-beta 9 loop, said FGF-2 variant characterized in at least one of the following attributes compared to the corresponding wild type FGF-2: enhanced specificity for one receptor subtype; increased biological activity mediated by at least one receptor subtype with equivalent or reduced activity mediated through another receptor subtype; enhanced affinity to at least one receptor subtype; increased cell proliferation mediated through one receptor subtype, and wherein said FGF-2 variant is SEQ ID NO: 1, wherein the at least one substitution is replacement of asparagine at position 111 with an amino acid residue selected from the group consisting of: glycine, arginine, valine, glutamic acid, and serine.