Patent ID: 6500432
Filing Date: 2002-12-31
Classification: A61K,A61P,C12N

Abstract:
A method for enhancing an immune response in an subject wherein the immune response is induced by administration of a polynucleotide, the method comprising the steps of:(1) administering a polynucleotide encoding a polypeptide; and (2) administering the polypeptide encoded by the polynucleotide administered in (1) wherein the polypeptide is administered 1-10 days after the polynucleotide is administered and wherein the method results in an increase in the immune response to the polypeptide as measured by one or more members selected from the group consisting of (i) total antibody titer, (ii) lymphoproliferation and (iii) cyctotoxic T cell level when compared to the immune response induced by administration of the polynucleotide in the absence of administration of the polypeptide.