Patent ID: 9044444
Filing Date: 2015-06-02
Classification: A61K,A61P,A61Q

Abstract:
1. A method for improving skin appearance of a subject, comprising administering to the subject an effective amount of a buffy coat comprising peripheral monocytes in a form of a composition, wherein the peripheral monocytes are stem cells with surface antigen CD34 induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and at least one of interleukin-3 (IL-3) and interleukin-6 (IL-6), and wherein the concentration of the stem cells with surface antigen CD34 in the composition is about 10 2 to about 10 9 cells per micro liter of the composition, such that the subject's skin exhibits a biochemical or physiological response evidenced by an increased level of at least one characteristic selected from the group consisting of collagen, elastin, polysaccharides, hyaluronic acid and CD44.