Patent ID: 6046191
Filing Date: 2000-04-04
Classification: A61K,A61P

Abstract:
A pharmaceutical combination comprising a COX-2 inhibitor or a pharmaceutically acceptable salt thereof and a compound of formula I: ##STR4## in which R represents:(i) phenyl, benzothiazolyl or a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms, which phenyl, benzo ring of the benzothiazolyl or heterocyclic aromatic ring is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, hydroxy, thioC.sub.1-6 alkyl, benzyloxy, or a group --Q(CH.sub.2).sub.p NR.sup.4 R.sup.5 ; or(ii) C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-8 alkynyl, piperidyl, C.sub.7-14 phenylalkyl, which alkyl, cycloalkyl, alkynyl, or piperidyl is optionally substituted by a group --(CH.sub.2).sub.p NR.sup.4 R.sup.5, the phenylalkyl being optionally substituted by a group --(CH.sub.2).sub.p NR.sup.4 R.sup.5, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or nitro; or(iii) a 5 membered heterocyclic aromatic ring containing 1 to 3 heteroatoms independently selected from O, N or S, optionally substituted by C.sub.1-6 alkyl, C.sub.7-14 phenylalkyl or halogen; or(iv) hydrogen or C.sub.7-14 phenylalkynyl;Q represents O, NR.sup.6 or a bond;R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trimethylsilyl or halogen;R.sup.2 represents hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by C.sub.1-6 alkyl,C.sub.1-6 alkoxy, halogen or hydroxy;R.sup.3 represents hydrogen or halogen;R.sup.4, R.sup.5 and R.sup.6 independently represent hydrogen or C.sub.1-6 alkyl,or --NR.sup.4 R.sup.5 together represents piperidyl, pyrrolidinyl or morpholinyl;p represents an integer 1 to 5; andA represents a thieno or benzo ring;or a pharmaceutically acceptable salt thereof, wherein said combination has greater antiinflammatory efficacy as compared to the efficacy of said COX-2 inhibitor and said compound taken alone.