Patent ID: 7582758
Filing Date: 2009-09-01
Classification: A61P,C07F

Abstract:
1. A method for the diastereoselective preparation of compounds of Formula II: wherein: V is selected from group consisting of aryl, and monocyclic heteroaryl, all optionally substituted with 1-4 substituents; W and W′ are independently selected from the group consisting of H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted monocyclic aryl, and optionally substituted monocyclic heteroaryl; Z is selected from the group consisting of halogen, —CN, —COR T is selected from the group consisting of H and lower alkyl; R R R p is 2 or 3; r is 0 or 1, and s is 0 or 1; R R the method comprising: combining a 1-(V)-1,3-propane diol with a compound of Formula III in the presence of a Lewis acid: wherein the ratio of cis- to trans-diastereomers of the compounds of Formula II formed is greater than or equal to 3:1.