Patent ID: 6010860
Filing Date: 2000-01-04
Classification: C07K,C12N,C12Q

Abstract:
A chimeric protein comprising:a first domain, which domain comprises a sequence-specific DNA-binding domain or which domain comprises a protein-binding domain which indirectly attaches said chimeric protein to a specific recognition sequence of a nucleic acid through attachment of said protein-binding domain to at least one other protein which facilitates attachment of said chimeric protein to said specific recognition sequence of a nucleic acid; anda second domain, which domain comprises an integrase protein or a fragment of said integrase protein which integrates donor nucleic acid into target nucleic acid,wherein the first domain is heterologous to the second domain and the carboxyl terminus of the first domain is joined to the amino terminus of the second domain or the carboxyl terminus of the second domain is joined to the amino terminus of the first domain.