Patent ID: 6277387
Filing Date: 2001-08-21
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A method for the treatment of sensitive skin in an individual having sensitive skin in need of said treatment, said method comprising administering to said individual a composition adapted for the treatment of sensitive skin comprising at least one compound selected from the group consisting of interleukin-1 antagonists, TNF alpha antagonists and combinations thereof, in an amount effective to treat sensitive skin, and a cosmetically, dermatologically or pharmaceutically acceptable medium, said compound being capable of inhibiting the IL-1-induced adhesion of macrophages to endothelial cells, inhibiting the IL-1-induced release of superoxide anions from neutrophils, inhibiting the TNF alpha-induced adhesion of macrophages to endothelial cells, inhibiting the TNF alpha-induced release of superoxide anions from neutrophils, inhibiting the mitogenic activity of TNF alpha by dermal fibroblasts, or inhibiting the release of interleukin-1 or TNF alpha by phorbol ester induced differentiated monocytes.