Patent ID: 6028170
Filing Date: 2000-02-22
Classification: A61K,C07K,Y10S

Abstract:
An antithrombogenic conjugate comprising:an antithrombogenic molecule having an amino acid sequence of sequence I.D. No. 2;a spacer attached to Tyr in position 35 of the antithromobogenic molecule, the Tyr in position 35 having a primary amine in the phenolic ring, wherein the spacer is selected from the group consisting of N-hydroxysuccinmidyl esters, imidate esters, thiolactones, carboxyanhydrides, sulfonyl halides, isourea esters, benzoquinones, vinyl sulfones, hydrazides and imidazolyl carbonyls: and a macromolecule or metal attached to the spacer wherein the macromolecule is selected from the group consisting of proteins and mPEG.