Patent ID: 6242434
Filing Date: 2001-06-05
Classification: A61K,A61P,C07C

Abstract:
A method of achieving an effect in a patient comprising administering an effective amount of a vitamin D compound which is a 24-hydroxyvitamin D wherein the effect is treating or preventing bone loss or bone mineral content, hyperparathyroidism, hyperproliferation, or modulating the immune and inflammatory responses, and wherein said 24-hydroxyvitamin D is a compound of formula (I): ##STR9##wherein Z is a side chain of formula IIC, IID, or IIE: ##STR10##wherein a dotted line along the side chain represents an optional additional C--C bond; q is zero; R.sup.3 is hydrogen, lower alkyl, lower fluoroalkyl, lower alkenyl or lower fluoroalkenyl; R.sup.4 and R.sup.7 are independently lower alkyl, lower fluoroalkyl, lower alkenyl or lower fluoroalkenyl; A is carbon, oxygen, sulfur or nitrogen; r is 1 and s is zero when A is nitrogen; r and s are 1 when A is carbon; r and s are zero when A is sulfur or oxygen; R.sup.9 and R.sup.10 are independently hydrogen, lower alkyl, lower alkenyl, lower fluoroalkyl or lower fluoroalkenyl; n is 1; Y is a methylene group if Y is double bonded to the A-ring or a methyl group or hydrogen if Y is single bonded; and X is hydrogen, lower alkyl or lower fluoroalkyl.