Patent ID: 6552037
Filing Date: 2003-04-22
Classification: C07D,G01N

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein:A, B, C, and D independently represent i) hydrogen, hydroxy, halogen, cyano, nitro, ii) C1-C6 alkyl optionally substituted independently with one, two, or three of Ra, iii) C2-C6 alkenyl optionally substituted independently with one, two, or three of Ra, iv) C2-C6 alkynyl optionally substituted independently with one, two, or three of Ra, v) C1-C6 alkoxy optionally substituted independently with one, two, or three of Ra, vi) alkylthio optionally substituted independently with one, two, or three of Ra, vii) alkylsulfinyl wherein the alkyl portion is optionally substituted independently with one, two, or three of Ra, viii) alkylsulfonyl wherein the alkyl portion is optionally substituted independently with one, two, or three of Ra, ix) â€”NR3R4, wherein R3 and R4 are independently hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, or C3-C7 cycloalkyl (C1-C6)alkyl, and x) â€”NR3R4, wherein R3 and R4 are joined to form a heterocyclic ring having from 3-7 members, where Ra is independently chosen at each occurrence from halogen, hydroxy, C1-C6 alkoxy, nitro, cyano, amino, or oxo,G is imidazolyl, imidazopyridinyl, imidazopyrazinyl, or benzimidazolyl, each of which is optionally substituted with up to three groups independently selected from: i) halogen, halo(C1-C6)alkyl, hydroxy, nitro, cyano, ii) arylalkyl, wherein the aryl portion of the arylalkyl moiety is optionally substituted with one, two, or three groups which are independently chosen from halogen, nitro, cyano, hydroxy, halo(C1-C6)alkyl, amino, mono- and di-alkyl(C1-C6)amino, iii) â€”NR5R6 wherein R5 and R6 are the same or different and independently represent hydrogen, alkoxyalkyl, or C1-C6alkyl substituted with â€”(CH2)mâ€”NR7R8, wherein m is 0 or an integer of from 1 to 6 and R7, and R8 are the same or different and represent hydrogen, C1-C6 alkyl, C3-C7cycloalkyl, or C3-C7 cycloalkyl(C1-C6)alkyl, iv) C1-C6 alkyl and C1-C6 alkoxy, each of which is optionally substituted with one or two of Rb, and v) heterocycloalkyl optionally substituted with up to three groups which are independently chosen from halogen, hydroxy, nitro, cyano, halo(C1-C6)alkyl, C1-C6alkyl, (C1-C6)alkoxy, (C1-C6)alkoxy (C1-C6)alkyl, (C1-C6)alkoxy (C1-C6)alkoxy, (C3-C7)cycloalkyl (C1-C6)alkoxy, cycloalkyl(C1-C6)alkyl, hydroxy(C1-C6)alkyl, hydroxy(C1-C6)alkoxy, amino(C1-C6)alkyl, and phenyl; W is phenyl or pyridyl, each of which is optionally substituted with one, two, or three groups which are independently chosen from i) halogen, nitro, cyano, hydroxy, halo(C1-C6)alkyl, amino, mono- and di-(C1-C6)alkylamino, ii) C1-C6 alkyl and C1-C6 alkoxy, each of which is optionally substituted with one or two of Rc, Rb and Rc are independently chosen at each occurrence from: i) hydroxy, C1-C6alkoxy, C3-C7cycloalkyl, C3-C7cycloalkyl(C1-C6)alkoxy, heterocycloalkyl, ii) â€”(CH2)xâ€”NR9R10, wherein x is 0 or an integer of 1 to 6, and R9 and R10 are the same or different and represent hydrogen, C1-C6 alkyl, C3-C7cycloalkyl, or C3-C7 cycloalkyl(C1-C6)alkyl, and iii) â€”NR9R10, where R9 and R10 are joined to form a heterocyclic ring having from 3-7 members; and X is O, NH, N(C1-C6 alkyl), S, SO2, or (CH2)n, wherein n is 1, 2, 3, or 4.