Patent ID: 8058277
Filing Date: 2011-11-15
Classification: A61P,C07D

Abstract:
1. A method for inhibiting the activity of a glycine transporter comprising contacting said transporter with a compound of Formula I wherein R A is straight-chain or branched alkyl having from 1 to 10 carbon atoms, alkenyl having from 2 to 10 carbon atoms or alkoxyalkyl having from 2 to 10 carbon atoms, and D-E is R R Het is a saturated, unsaturated or aromatic mono- or bicyclic heterocyclic radical which is unsubstituted or mono- or polysubstituted by A, Hal, NO Ar is an aromatic hydrocarbon radical having from 6 to 14 carbon atoms which is unsubstituted or mono- or polysubstituted by A, Hal, NO w is 0, 1, 2 or 3, and n and m, independently of one another, are 0, 1, 2, 3, 4 or 5; X Q is selected from O, S, N—R g is 1, 2, 3, 4, 5 or 6, h and k, independently of one another, are 0, 1, 2, 3, 4, 5 or 6, and R P is 0, 1, 2 or 3, E is H, A, (CH G is an optionally substituted alkylene radical having from 1 to 4 carbon atoms, where the substituents are selected from the meanings indicated for R or E and G, together with the N atom to which they are bonded, are an un-substituted or substituted 5-, 6- or 7-membered, mono- or bicyclic heterocyclic radical, which may have 1, 2 or 3 further heteroatoms selected from N, O and S, X Z is H or is a saturated, mono- or polyethylenically unsaturated or aromatic carbocyclic radical having from 5 to 10 carbon atoms or a saturated, mono- or polyethylenically unsaturated or aromatic heterocyclic radical having from 4 to 9 carbon atoms, where the carbocyclic or heterocyclic radical may be mono- or polysubstituted, where the substituents are selected, independently of one another, from the meanings of R and Hal is F, Cl, Br or I, or a pharmaceutically acceptable salt, stereoisomer or mixture of said compound of Formula I.