Patent ID: 7951827
Filing Date: 2011-05-31
Classification: A61P,C07D,Y02A

Abstract:
1. A compound of Formula (I): wherein: R s and t are each 1; y and z are each independently an integer from 0 to 3; X wherein: or a pharmaceutically acceptable salt thereof; and wherein the compound of Formula (I) is a compound selected from the group consisting of: 3,5-Bis[4-(N-isopropyl)amidinophenyl]isoxazole; 3,5-Bis[4-(2-imidazolinyl)phenyl]isoxazole; 5-(4-Amidino-2-nitrophenyl)-3-(4-amidinophenyl)isoxazole; 5-(4-Amidino-2-chlorophenyl)-3-(4-amidinophenyl)isoxazole; 5-(4-Amidino-2-methoxyphenyl)-3-(4-amidinophenyl)isoxazole; 3-(4-Amidino-2-nitrophenyl)-5-(4-amidinophenyl)isoxazole; 3-(4-Amidino-2-chlorophenyl)-5-(4-amidinophenyl)isoxazole; 3-(4-Amidino-2-methoxyphenyl)-5-(4-amidinophenyl)isoxazole; 3,5-Bis(4-amidino-2-methoxyphenyl)isoxazole; 3,5-Bis[4-(N-hydroxy)amidino-2-methoxyphenyl]isoxazole; 3,5-Bis[4-(N-acetoxy)amidino-2-methoxyphenyl]isoxazole; 3,5-Bis[3-(N-isopropyl)amidinophenyl]isoxazole; 3,5-Bis[3-(2-imidazolinyl)phenyl]isoxazole; 5-(5-Amidino-2-nitrophenyl)-3-(3-amidinophenyl)isoxazole; 5-(5-Amidino-2-chlorophenyl)-3-(3-amidinophenyl)isoxazole; 5-(5-Amidino-2-methoxyphenyl)-3-(3-amidinophenyl)isoxazole; 3-(5-Amidino-2-nitrophenyl)-5-(3-amidinophenyl)isoxazole; 3-(5-Amidino-2-chlorophenyl)-5-(3-amidinophenyl)isoxazole; 3-(5-Amidino-2-methoxyphenyl)-5-(3-amidinophenyl)isoxazole; 3,5-Bis(5-amidino-2-methoxyphenyl)isoxazole; 3,5-Bis[5-(N-isopropyl)amidino-2-methoxyphenyl]isoxazole; 3,5-Bis[5-(2-imidazolinyl)-2-methoxyphenyl]isoxazole; 3-[3-(N-Isopropyl)amidinophenyl]-5-[4-(N-isopropyl)amidino-phenyl]-isoxazole; 3-[3-(2-Imidazolinyl)phenyl]-5-[4-(2-imidazolinyl)phenyl]-isoxazole; 5-(4-Amidino-2-nitrophenyl)-3-(3-amidinophenyl)isoxazole; 5-(4-Amidino-2-chlorophenyl)-3-(3-amidinophenyl)isoxazole; 5-(4-Amidino-2-methoxyphenyl)-3-(3-amidinophenyl)isoxazole; 3-(5-Amidino-2-nitrophenyl)-5-(4-amidinophenyl)isoxazole; 3-(5-Amidino-2-chlorophenyl)-5-(4-amidinophenyl)isoxazole; 3-(5-Amidino-2-methoxyphenyl)-5-(4-amidinophenyl)isoxazole; 3-[4-(N-Isopropyl)amidinophenyl]-5-[3-(N-isopropyl)amidino-phenyl]-isoxazole; 3-[4-(2-Imidazolinyl)phenyl]-5-[3-(2-imidazolinyl)phenyl]-isoxazole; 5-(5-Amidino-2-chlorophenyl)-3-(4-amidinophenyl)isoxazole; 5-(5-Amidino-2-methoxyphenyl)-3-(4-amidinophenyl)isoxazole; 3-(4-Amidino-2-nitrophenyl)-5-(3-amidinophenyl)isoxazole; 3-(4-Amidino-2-chlorophenyl)-5-(3-amidinophenyl)isoxazole; 3-(4-Amidino-2-methoxyphenyl)-5-(3-amidinophenyl)isoxazole; 5-(5-Amidino-2-methoxyphenyl)-3-(4-amidino-2-nitrophenyl)isoxazole; and 3-(4-Amidino-2-methoxyphenyl)-5-(5-amidino-2-methoxy-phenyl)-isoxazole, or a pharmaceutically acceptable salt thereof.