Patent ID: 8283454
Filing Date: 2012-10-09
Classification: A61P,C07D,C07H

Abstract:
1. A method for the preparation of a complex of Formula IA: wherein the subscript n is 1 or 2; R V is a member selected from the group consisting of oxygen and a single bond; W is a member selected from the group consisting of C X is a member selected from the group consisting of oxygen and NR Y is a member selected from the group consisting of hydrogen, C wherein alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or portions of W, X and Y are optionally partly or completely fluorinated and are optionally mono- or disubstituted by substituents independently selected from the group consisting of chlorine, hydroxy, C R each R and pharmaceutically acceptable salts thereof; comprising: and wherein steps (a) and (b) are performed without purification of said compound of Formula III and wherein steps (a) and (b) are performed sequentially without an intervening protection or deprotection step.