Patent ID: 8703099
Filing Date: 2014-04-22
Classification: C07B,C07D,G16H

Abstract:
1. A method for monitoring use by a patient of a prescribed controlled drug to identify when a patient is using the controlled drug from sources other than as prescribed, the method comprising: (a) identifying a stable isotope that can be made part of the molecular structure of the controlled drug at a metabolically stable site thereof without affecting the pharmacologic activity of the controlled drug and wherein the stable isotope is retained on the molecular structure while it is in tissues or body fluid of a patient; (b) synthesizing an isotopically labeled version of the controlled drug by adding the stable isotope onto the molecular structure of the controlled drug; (c) prescribing the isotopically labeled version of the controlled drug to the patient; (d) recording the patient's prescription for the isotopically labeled version of the controlled drug in a registry; (e) testing a fluid or tissue sample from the patient for the presence of the controlled drug and, when detecting presence of the controlled drug, determining whether the detected controlled drug is the isotopically labeled version of the controlled drug found in the registry.