Patent ID: 6495687
Filing Date: 2002-12-17
Classification: A61P,C07D

Abstract:
An assay-type probe comprising:(1) a compound of the formula: â€ƒwherein R1 is selected from the group consisting of C1-C8 alkyl R2 is of the formula: â€ƒwherein n is an integer ranging from 1 to 8; R5 is H or CH3(CH2)p, wherein p is an integer ranging from 1 to 7; and R6 is H or (CH2)mOH, wherein m is an integer ranging from 1 to 8; R3 is of the formula: â€”(CH2)qC6H4â€”R7 â€ƒwherein q is an integer ranging from 1 to 8; and wherein R7 is selected from the group consisting of H, NH2, R9COOH, wherein R9 is an alkylene or alkenylene group having 1 to 8 carbon atoms, and (CH2)tOH, wherein t is an integer ranging from 1 to 8; and R4 is of the formula: â€ƒwherein R8 is selected from the group consisting of H; NH2; (CH2)sOH, wherein s is an integer ranging from 1 to 8; and R10COOH, wherein R10 is an alkylene or alkenylene group having 1 to 8 carbon atoms; and r is an integer ranging from 1 to 8; and (2) non-radioactive material; wherein said compound is labeled by said non-radioactive material by a spacer component present thereon, wherein the spacer component has functionality which bonds to the amine, hydroxyl, or carboxyl functionality present on the R7 or R8 substituent of said compound.