Patent ID: 9095613
Filing Date: 2015-08-04
Classification: A61K,A61P,Y10T

Abstract:
1. A photosensitizer gold nanoparticle charge complex for photodynamic therapy and fluorescence imaging, comprising: a photosensitizer charged with a first charge; a gold nanoparticle that transfers resonance energy with the photosensitizer to quench fluorescence of the photosensitizer and singlet oxygen generation; and a linker bound to the gold nanoparticle and charged with a second charge having an opposite polarity to the first charge, and bound to the photosensitizer through the charge of the photosensitizer interaction between the first charge and the second charge of the linker, wherein the gold nanoparticle has an average length of 34 nm; and wherein the linker is a polypeptide containing cysteine (Cys) having the thiol group as a residue on one terminal, and arginine (Arg), lysine (Lys) or histidine (His) having a cation as a residue or aspartic acid (Asp) or glutamic acid (Glu) having an anion as a residue on the other terminal.