Patent ID: 6676972
Filing Date: 2004-01-13
Classification: A61K,Y10S

Abstract:
A composition of matter comprising an activated antibiotic, antimicrobial or antiviral compound, a porous microparticle, and a coating material, wherein the antibiotic, antimicrobial or antiviral activity of the compound requires modification in vivo by an enzymatic or chemical activity specific for infected cells and resistance to said compound is mediated by inactivation of said enzymatic or chemical activity, whereby the compound is activated in vitro by chemically modifying the compound to overcome resistance thereto, wherein the porous microparticle is impregnated with the compound and said coated microparticle is further coated with the coating material, and wherein the coating material is specifically degraded inside a phagocytic mammalian cell infected with a microorganism to allow release of the compound within the infected cell.