Patent ID: 6184223
Filing Date: 2001-02-06
Classification: A61K,A61P,C07D,C07K,C40B,Y10S

Abstract:
A method for treating a cell adhesion-mediated disease comprising administering to a warm-blooded animal in need thereof a composition comprising a therapeutically effective amount of a compound having the structure: ##STR111##whereinY is selected from --CH(R.sub.5)--A--N(R.sub.1)--, --A--N(R.sub.1)--CH(R')--, --A--N(R.sub.1)--C(.dbd.O)--, --A--C(.dbd.O)--N(R.sub.1)--, --A--CH(R.sub.1)--O-- and --A--CH(R.sub.1)--N(R')--;A is --(CHR').sub.n --, where n=0, 1 or 2;B is --(CHR"").sub.m --, where m=1, 2 or 3;R', R"", R.sub.2, R.sub.3 and R.sub.5 are the same or different and independently selected from an amino acid side chain moiety or derivative thereof, a linker and a solid support; andR.sub.1 and R.sub.4 represent the remainder of the compound; andwherein any two adjacent CH groups or adjacent NH and CH groups on the fused bicyclic ring may optionally form a double bond; in combination with a pharmaceutically acceptable carrier or diluent.