Patent ID: 9133455
Filing Date: 2015-09-15
Classification: A61P,C12N

Abstract:
1. An oligonucleotide with a length of 15 or 16 nucleobase units for inhibition of microRNA-155, wherein the oligonucleotide comprises a core nucleobase sequence from positions one to six, two to seven or from positions three to eight, counting from the 3′ end of 3′-ttacga-5′ (SEQ ID NO: 8), wherein; (a) at least one nucleobase unit in said sequence have been substituted by its corresponding LNA unit; (b) the nucleobase sequence of the oligonucleotide is complementary to a human microRNA-155 sequence; (c) the oligonucleotide does not comprise a region of more than 5 consecutive DNA units; (d) the oligonucleotide comprises at least one phosphorothioate internucleoside linkage; (e) the oligonucleotide comprises at least one DNA unit; and, wherein said oligonucleotide can educe the level of microRNA-155.