Patent ID: 6730669
Filing Date: 2004-05-04
Classification: A61K,A61P,C07D,C07K

Abstract:
Compound represented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein n represents 1 or 2;R1 represents an alkyl of 1-5 carbon atoms, an alkenyl of 2-5 carbon atoms, an alkynyl of 2-5 carbon atoms, a hydroxyalkyl of 1-3 carbon atoms, an alkoxyalkyl of 1-3 alkyl and 1-3 alkoxy carbon atoms, a cyanoalkyl of 1-3 alkyl carbon atoms, imidazolylmethyl â€”CH2CONH2, â€”CH2CH2CONH2, â€”CH2S(O)2NH2, â€”CH2SCH3, â€”CH2S(O)CH3, â€”CH2S(O)2CH3, â€”C(CH3)2SCH3, â€”C(CH3)ZS(O)CH3or â€”C(C113)S(O)zCH3radicals; R2 represents an alkyl of 1-5 carbon atoms, an aralkyl of 1-3 alkyl carbon atoms, an alkylthioalkyl of 1-3 alkyl carbon atoms, an arylthioalkyl of 1-3 alkyl carbon atoms, or a cycloalkylalkyl of 1-3 alkyl carbon atoms and 3-6 ring member carbon atoms; R3 represents an alkyl of 1-5 carbon atoms, a cycloalkyl of 5-8 ring members or a cycloalkylmethyl radical of 3-6 ring members; A and B each independently represent CH2, O, S, SO or SO2; R6 represents hydrogen, deuterium, an alkyl of 1-5 carbon atoms, fluoro or chloro, R7 represents hydrogen, deuterium, methyl, fluoro or chloro; R7 represents hydrogen; alkyl hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl is 1-3 carbon atoms; R11 represents hydrogen, alkyl of 1-5 carbon atoms, hydroxyalkyl of 1-4 carbon atoms, alkoxyalkyl of 1-3 alkyl carbon atoms, benzyl, imidazolylmethyl, â€”CH2CH2CONH2, â€”CH2CONH2, â€”CH2CH2SCH3, or â€”CH2SCH3radicals or the sulfone or sulfoxide derivatives thereof; R12 represents hydrogen, hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl is 1-3 carbon atoms; and R13 and R14 each independently represent hydrogen, hydroxy, alkoxy, 2-hydroxyethoxy, hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl is 1-3 carbon atoms; or R12 and R13 or and R14 along with the carbon atoms to which they are attached represent 5-6 ring membered heteroaryl or benzo radical, each of which is optionally substituted with at least one hydroxy or alkoxy radical of 1-3 carbon atoms.