Patent ID: 6300347
Filing Date: 2001-10-09
Classification: A61P,C07D,C07F

Abstract:
A compound of formnula I ##STR32##whereinR.sub.1 is 4pyridyl which is optionally substituted with one or two substituents each of which is independently selected from C.sub.1-4 alkyl, halogen, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio and NR.sub.5 R.sub.6 where R.sub.5 andR.sub.6 are each independently C.sub.1-4 alkyl;R.sub.2 is phenyl, naphth-1-yl or naphth-2-yl which is optionally substituted by up to five substituents;R.sub.3 is hydrogen; and,R.sub.4 is optionally substituted pyridyl; in free or pharmaceutically acceptable acid addition salt or physiologically cleavable ester form, provided that R.sub.2 is not phenyl substituted with a radical selected from alkylsulfonyl or aminosulfonyl.