Patent ID: 6602866
Filing Date: 2003-08-05
Classification: A61P,C07D

Abstract:
A compound of the formula I whereinR1 is hydrogen, â€”CH2OC(O)C(CH3)3, (C1-C4)alkanoyl, benzoyl, or an acyl group of the formula R2 is hydrogen, â€”CH2Oâ€”C(O)C(CH3)3, a C1-C4-alkyl, aryl, aryl-(C1-C4-alkyl) or diphenylmethyl; X is â€”(CH2)n wherein n is an integer 0 or 1, â€”Sâ€”, â€”Oâ€”, wherein R3 is hydrogen, a C1-C4-alkyl, aryl, or aryl-(C1-C4-alkyl) and R4 is â€”CF3, C1-C10-alkyl aryl, or aryl-(C1-C4-alkyl); B1 and B2 are each independently hydrogen, hydroxy, or â€”OR5, wherein R5 is C1-C4-alkyl, aryl, or aryl-(C1-C4-alkyl) or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbon atoms to form a benzene ring or methylenedioxy; or its pharmaceutically acceptable salts or stereoisomers thereof.