Patent ID: 6103871
Filing Date: 2000-08-15
Classification: A61K,C12N,Y10S

Abstract:
An isolated polypeptide comprising a member selected from the group consisting of:(a) a polypeptide of the amino acid sequence of SEQ ID NO:2 or encoded by the human cDNA in ATCC Deposit No: 75882;(b) a polypeptide fragment of the amino acid sequence of SEQ ID NO:2 or encoded by the human cDNA in ATCC Deposit No: 75882, wherein said fragment has human MutT2 activity;(c) an antigenic fragment of the amino acid sequence of SEQ ID NO:2 or encoded by the human cDNA in ATCC Deposit No: 75882, wherein said fragment is recognized by an antibody which specifically binds human MutT2;(d) a polypeptide fragment comprising Gly-Glu-Thr-Pro-Glu and Arg-Glu-Leu-Glu-Glu-Glu domains of SEQ ID NO:2 or encoded by the human cDNA in ATCC Deposit No: 75882;(e) a polypeptide fragment of at least 30 contiguous amino acids of SEQ ID NO:2 or encoded by the human cDNA in ATCC Deposit No: 75882; and(f) a polypeptide variant of (a), (b), (c), (d), or (e) resulting from conservative substitutions.