Patent ID: 6709810
Filing Date: 2004-03-23
Classification: A61L,A61P

Abstract:
A method of treating a material comprising red blood cells, the method comprising,a) adding a pathogen inactivating compound to the material comprising red blood cells in order to inactivate a pathogen, if present in the material, said pathogen inactivating compound comprising a nucleic acid binding ligand linked by a frangible linker to a functional group which is, or which forms, an electrophilic group, wherein the electrophilic group can react covalently with the nucleic acid; and b) adding a sufficient amount of a quencher to the material comprising red blood cells in order to reduce the level of side reactions of the pathogen inactivating compound, wherein the quencher comprises a nucleophilic group that can react covalently with the electrophilic group and wherein the pathogen inactivating compound inactivates at least about 1 log of the pathogen.