Patent ID: 9051547
Filing Date: 2015-06-09
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for promoting healing of a corneal or an epithelial wound in a subject, comprising administering a therapeutically effective amount of a synthetic peptide to the subject to promote stem cells associated with the corneal or epithelial wound of the subject to proliferate, wherein the stem cells are limbal epithelial stem cells or hair follicle stem cells, the amino acid sequence of the synthetic peptide consists of 20-39 amino acid residues and has at least 80% amino acid sequence identity to SEQ ID NO: 1, wherein at least 20consecutive residues of the synthetic peptide has 100% amino acid sequence identity to residues 11-30 of SEQ ID NO: 1, and the percentage in healing of the corneal wound is increased by up to 90% after 48 hours or the percentage in healing of the epithelial wound is increased by up to 50% after 7 days as compared to corneal wound or epithelial wound healing with full-length human Pigment epithelium-derived factor (PEDF).