Patent ID: 6492427
Filing Date: 2002-12-10
Classification: A61K,A61P

Abstract:
A method for increasing survival of oligodendrocytes, comprising administering an effective amount of a deprenyl compound to a patient in need there of, wherein the deprenyl compound is represented by the structure: in which R1 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, or aryloxycarbonyl; R2 is hydrogen or alkyl; R3 is a single bond, alkylene, or â€”(CH2)nâ€”Xâ€”(CH2)m; in which X is O, S, or N-methyl; m is 1 or 2; and n is 0, 1, or 2; R4 is alkyl, alkenyl, alkynyl, heterocycylyl, aryl or aralkyl; and R5 is alkylene, alkenylene, alkynylene and alkoxylene; and R6 is C3-C6 cycloalkyl or R2 and R4-R3 are joined to form, together with the methine to which they are attached, a cyclic or polycyclic group; and pharmaceutically acceptable salts thereof, such that survival of oligodendrocytes is increased.