Patent ID: 7160543
Filing Date: 2007-01-09
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting TNFα in a human patient, wherein said human patient has Crohn's disease, comprising administering to the human an effective TNFα-inhibiting amount of an anti-TNFα antibody or antigen-binding fragment thereof, said antibody comprising a human constant region, wherein said anti-TNFα antibody or antigen-binding fragment thereof (i) competitively inhibits binding of A2 (ATCC Accession No. PTA-7045) to human TNFα and (ii) binds to a neutralizing epitope of human TNFα with an affinity of at least 1×10 8 liter/mole, measured as an association constant (Ka), as determined by Scatchard analysis.