Patent ID: 6479067
Filing Date: 2002-11-12
Classification: A61K,A61P,Y10S

Abstract:
A biodegradable polymer composition suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer, said composition comprising:(a) at least one antineoplastic agent and (b) a biodegradable polymer comprising the recurring monomeric units shown in formula II: wherein:each of R1, R2 and R5 is a divalent organic moiety; R3 is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; n is about 5-5,000; the molar ratio of x:y is about 1; and the molar ratio n:(x or y) is between about 200:1 and 1:200; wherein said polymer composition provides extended release of said antineoplastic agent into the peritoneum of said subject; and wherein said polymer composition increases the median survival rate of said mammalian subject from said cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of said antineoplastic agent without said biodegradable polymer.