Patent ID: 6599937
Filing Date: 2003-07-29
Classification: C07C

Abstract:
A method of modulating gene expression in a hematopoietic cell, comprising administering to said cell an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof: whereinR is C2-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl or heteroaryl, any of which can be optionally substituted with halo, trifluoromethyl, hydroxy, alkoxy, cyano, nitro or carbonyl, wherein the heteroatom of said heteroaryl is oxygen or sulfur; R1 and R2 are independently H, C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl, any of which can be optionally substituted with halo, alkoxy, amino, trifluoromethyl, aryl or heteroaryl; A is R3 is independently each of R4, R5, R6 and R7 is independently H, alkyl or alkenyl; B is aryl or heteroaryl, wherein the heteroatom of said heteroaryl is oxygen or sulfur; each of m and n is independently 0 to 5; the sum of m and n is 1 to 5; and each of p, q and r is independently 0 to 2; with the proviso that when p, q and r are 0, each R3 is â€”CR6&boxH;CR7â€”, R6 is H or methyl and R7 is H or methyl, then the sum of m and n can not be 4 or 5.