Patent ID: 7241892
Filing Date: 2007-07-10
Classification: A61P,C07D,Y02P

Abstract:
1. A method for preparing a compound of formula (XVIIc): where: R R R R R R R R R and derivatives including compounds where the —NH from a 21-cyano compound of formula (XVIb): where: R R R R R R provided that at least one of the rings A or E is a p-benzoquinone ring; the reactions of the method comprising as needed: a) converting a quinone system for said ring E into the phenol system b) converting a quinone system for said ring A into the phenol system; c) converting the phenol system for said ring A into a methylenedioxyphenol ring; d) forming a bridged spiro ring system of formula selected from the group consisting of formula (IV), (V), (VI) and (VII) across the 1-position and 4-position in ring B; and e) acylation; (f) converting a compound where R (g) converting a 21-cyano substituent to a substituent —OH.