Patent ID: 8980243
Filing Date: 2015-03-17
Classification: A61K,A61P

Abstract:
1. A method for increasing oxygenation of a wound, comprising topically administering a composition selected from the group consisting of formulations A-U, wherein formulation A is: 17% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 75.0% poloxamer 188; formulation B is: 15.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18%, disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 70.0% poloxamer 188; formulation C is: 13.67% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 65.0% poloxamer 188; formulation D is: 12% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 60.0% poloxamer 188; formulation E is: 10.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 55.0% poloxamer 188; formulation F is: 8.67% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 50.0% poloxamer 188; formulation G is: 7% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 45.0% poloxamer 188; formulation H is: 5.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation I is: 5.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.20% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation J is: 2.0% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.30% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 0.1% poloxamer 188; formulation K is: 2% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.40% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 40.0% poloxamer 188; formulation L is: 3.67% aloe barbadensisl extract, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.50% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 35.0% poloxamer 188; formulation M is: 5.33% aloe barbadensis leaf extract, 12.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 1.0% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 30.0% poloxamer 188; formulation N is: 7.0% aloe barbadensis leaf extract, 15% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 2.0% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 25.0% poloxamer 188; formulation O is: 8.67% aloe barbadensis leaf extract, 1.0% linoleamidopropyl pg-dimonium chloride phosphate, 0.10% polysorbate 20, 1.0% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.15% disodium EDTA, 0.10% sodium benzoate, 0.15% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 20% poloxamer 188; formulation P is: 10.33% aloe barbadensis leaf extract, 5% linoleamidopropyl pg-dimonium chloride phosphate, 1.0% polysorbate 20, 5.0% sodium coco-pg dimonium chloride phosphate, 4.0% allantoin, 0.80% disodium EDTA, 0.15% sodium benzoate, 0.50% benzalkonium chloride, 0.5% iodopropynyl butylcarbamate, and 15.0% poloxamer 188; formulation Q is: 12% aloe barbadensis leaf extract, 7.5% linoleamidopropyl pg-dimonium chloride phosphate, 4.0% polysorbate 20, 7.5% sodium coco-pg dimonium chloride phosphate, 8.0% allantoin, 1.5% disodium EDTA, 2.0% sodium benzoate, 0.75% benzalkonium chloride, 0.75% iodopropynyl butylcarbamate, and 10.0% poloxamer 188; formulation R is: 30% aloe barbadensis leaf extract, 20% linoleamidopropyl pg-dimonium chloride phosphate, 6.0% polysorbate 20, 10% sodium coco-pg dimonium chloride phosphate, 20% allantoin, 2.0% disodium EDTA, 3.13% sodium benzoate, 1.5% benzalkonium chloride, 1.5% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation S is: 15.33% aloe barbadensis leaf extract, 15% linoleamidopropyl pg-dimonium chloride phosphate, 8.0% polysorbate 20, 15% sodium coco-pg dimonium chloride phosphate, 15% allantoin, 3.0% disodium EDTA, 3.38% sodium benzoate, 1.5% benzalkonium chloride, 1.5% Iodopropynyl butylcarbamate, and 2.5% poloxamer 188: formulation T is: 17% aloe barbadensis leaf extract, 17.5% linoleamidopropyl pg-dimonium chloride phosphate, 9% polysorbate 20, 17.5% sodium coco-pg dimonium chloride phosphate, 18% allantoin, 4.5% disodium EDTA, 4% sodium benzoate, 1.75% benzalkonium chloride, 1.75% iodopropynyl butylcarbamate, and 1.0% poloxamer 188; formulation U is: 20% aloe barbadensis leaf extract, 10% linoleamidopropyl pg-dimonium chloride phosphate, 10% polysorbate 20, 20% sodium coco-pg dimonium chloride phosphate, 12% allantoin, 5.0% disodium EDTA, 5.0% sodium benzoate, 2.0% benzalkonium chloride, 2.0% iodopropynyl butylcarbamate, and 1.0% poloxamer 188, and wherein the composition further comprises about 10% to about 50% of a standard therapeutically effective amount of at least one therapeutic agent selected from the group consisting of antimicrobial agent, analgesics, and combinations thereof to the wound.