Patent ID: 8535713
Filing Date: 2013-09-17
Classification: A61K,A61P

Abstract:
1. A method for treating a disease in a subject selected from: ischemic bowel diseases, necrotizing enterocolitis, Coeliac diseases, proctitis; an inflammatory bowel disease, ulcerative colitis, Crohn's disease, and/or irritable bowel syndrome, the method comprising orally administering to the subject an effective amount of cyclosporin in a solubilised liquid form included in an oral formulation which permits targeted release of the solubilised cyclosporin at least in the colon, the oral formulation being a multiple minicapsule or multiple minisphere formulation the formulation comprising minicapsules or minispheres in which the cyclosporine in a solubilized liquid form is encapsulated with a gelling agent, wherein a modified release coating is applied to the gelling agent, the modified release coating comprising a controlled release polymer suitable to provide the targeted release of the cyclosporin at least in the colon.