Patent ID: 6444663
Filing Date: 2002-09-03
Classification: A01N,A61K,A61P,C07K

Abstract:
A method of preventing or mitigating ischemic injury to a patient suffering from a disease having the potential to cause such an injury comprising administering, to a patient in need of such treatment, an effective amount of a pharmaceutical composition comprising a compound of the formula: wherein: n is 1 or 2; m is 1 or 2; A is R2COâ€”, R3â€”Oâ€”COâ€”, or R4SO2â€”; a group of the formula: further wherein: R1 is a hydrogen atom, alkyl or phenylalkyl; R2 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl, heteroaryl, or (heteroaryl)alkyl; R3 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenylalkyl or (substituted phenyl)alkyl; R4 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl, heteroaryl, or (heteroaryl)alkyl; R5 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, heterozryl, or (heteroaryl)alkyl; R6 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenylalkyl, or (substituted phenyl)alkyl; R7 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl, heteroaryl, or (heteroaryl)alkyl; R8 is an amino acid side chain chosen from the group consisting of natural and unnatural amino acids; B is a hydrogen atom, a deuterium atom, alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl, heteroaryl, (heteroaryl)alkyl, or halomethyl; a group of the formula: â€”CH2XR9; wherein R9 is phenyl, substituted phenyl, phenylalkyl, (substituted phenyl)alkyl, heteroaryl, and (heteroaryl)alkyl; and X is an oxygen or a sulfur atom;a group of the formula: CH2â€”Oâ€”COâ€”(aryl); or a group of the formula: â€”CH2â€”Oâ€”COâ€”(heteroaryl); a group of the formula: â€”CH2â€”Oâ€”POâ€”(R10)R11; wherein R10 and R11 are independently selected from a group consisting of alkyl, cycloalkyl, phenyl, substituted phenyl, phenylalkyl, and (substituted phenyl)alkyl;and a pharmaceutically-acceptable salt thereof.