Patent ID: 6482849
Filing Date: 2002-11-19
Classification: C07C,C07D

Abstract:
A compound of the formula (I): whereinn is an integer of 1; R1 is a hydrogen atom or methyl group; R2 is a group of the formula: â€”CN, â€”COOH, â€”(C1-6 alkylene) OH, â€”CH2O(C1-6 alkyl), â€”(C1-6 alkylene)COOH, â€”CH2O(C1-6 alkylene)O(C1-6 alkyl), â€”CH2O(C1-6 alkylene)COOH, â€”(C2-7 alkenylene) COOH, â€”CO(C1-6 alkylene)COOH, â€”CO(C2-7 alkenylene)COOH, â€”CO(C1-6 alkylene)O(C1-6 alkyl), â€”CO(C1-6 alkylene)CO(C1-6 alkyl), â€”CONH(C1-6 alkyl), â€”CONHO(C1-6 alkyl), â€”CONH(C1-6 alkylene)COOH, â€”CONH2, â€”CONH(C3-7 cycloalkyl), â€ƒâ€”CONHOCH2Ph, â€”CONH(C1-6 alkylene)CN, â€”COO(C1-6 alkyl), â€”CH2O(C1-6 alkylene)CONH2, â€”CONH(C1-6 alkylene)CONH2, â€”CONHOH, â€”NHCOOCH2Ph, R3 is a hydrogen atom or a methyl group; X is a methylene group or a group of the formula: â€”COâ€”; R4 is a hydrogen atom or a C1-6 alkyl group; R5 is a group of the formula: â€”COOH or an ester or an amide thereof, â€”(C1-6 alkylene)COOH or an ester or an amide thereof, â€”(C1-7 alkylene)O(C1-6 alkyl), â€”(C1-7 alkylene)OH, â€”COO(C1-6 alkyl), â€”CONH(C1-6 alkyl), or â€”CONH2; R6 is a substituent of the formula: â€ƒwherein, R7, which occurs one or more times and which may be the same or different in each occurrence, is â€”OH, â€”NO2, â€”NH2, â€”C1-C5 alkyl, â€”F, â€”Cl, â€”Br, â€”I, â€”COOH, â€”COO(C1-6 alkyl), â€”O(C1-C8 alkyl), â€”CONH(C1-6 alkylene)COOH, â€”OCH2(C3-C7 cycloalkyl) or a substituent of the formula R8, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”OH, â€”NH2, â€”NO2, â€”C1-C7 alkyl, â€”F, â€”Cl, â€”Br, â€”I, â€”CF3, phenyl, or â€”O(C1-6 alkyl); R9 is selected from a group of the formula: â€”H, â€”C1-C5 alkyl, â€”C3-C7 cycloalkyl, â€”(â€”C1-C6 alkylene)aryl, aryl, where aryl is a substituent of the formula: R10, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”F, â€”Cl, â€”Br, â€”I, â€”NO2, â€”C1-6 alkyl or â€”O(C1-6 alkyl) with the proviso that R1 and R3 must be different and also with the proviso that when R2 or R6 is a moiety of the formula â€”COOH or contains a moiety of the formula â€”COOH, then a pharmaceutically acceptable ester or a pharmaceutically acceptable amide thereof are included, and also with the proviso that when R7 is the formula R9 is other than hydrogen; or a pharmaceutically acceptable salt thereof.