Patent ID: 6395759
Filing Date: 2002-05-28
Classification: A61P,C07D

Abstract:
A compound of formula (I) or pharmaceutically acceptable salt thereof: whereG is a methylene or ethylene linkage; R1 is hydrogen, C1-6 alkylOâ€”; R2 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, CF3, CF3Oâ€”, CF3Sâ€”, CF3COâ€”, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylOâ€”, C1-6alkylCOâ€”, C3-6cycloalkylCOâ€”, C3-6cycloalkyl-C1-4alkylCOâ€”, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C1-4alkyl-, C1-6alkylSO2â€”, (C1-4alkyl)2NSO2â€” or (C1-4alkyl)NHSO2â€”; R3 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, C1-6 alkylOâ€”, C1-6 alkylSâ€”, C1-6 alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3COâ€”, C1-6alkylCOâ€”, C3-6cycloalkylCOâ€”, C3-6cycloalkyl-C1-4alkylCOâ€”, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, or â€”NR5R6 where R5 is hydrogen or C1-4 alkyl, and R6 is hydrogen, C1-4alkyl, â€”CHO, â€”CO2C1-4alkyl or â€”COC1-4alkyl; R4 is hydrogen, C1-6 alkyl, C1-6 alkenyl, or C1-6 alkynyl.