Patent ID: 9044474
Filing Date: 2015-06-02
Classification: A61K,G01N

Abstract:
1. A method of (a) treating a lymphoproliferative disease in a subject in need thereof; (b) slowing the progression of a lymphoproliferative disease in a subject who has been diagnosed with a lymphoproliferative disease; or (c) preventing or delaying development of a lymphoproliferative disease in a subject who is at risk of developing a lymphoproliferative disease, the method comprising administering to the subject an effective amount of a combination therapy consisting of: i) at least one autophagy inhibitor agent comprising chloroquine, or a pharmaceutically acceptable salt thereof; and ii) at least one CDK inhibitor agent comprising flavopiridol or a pharmaceutically acceptable salt thereof; in an amount sufficient to enhance the cytotoxicity of the combination relative to the CDK inhibitor agent treatment alone; wherein the subject has chronic lymphocytic leukemia (CLL).