Patent ID: 6713475
Filing Date: 2004-03-30
Classification: A61P,C07D

Abstract:
A compound of the formula (I) or (II): whereinm is an integer from 0 to 1; with the proviso that if m is 0 or 1, then â€œHETâ€  in the compound of formula (II) is a stable five- or six-membered monocyclic aromatic ring system composed of carbon atoms and one heteroatom, wherein the heteroatom is selected from the group consisting of N, O and S which may occupy any position in the ring whereby the resulting ring system is stable; A is selected from the group consisting of â€”C(O)â€”, SO2 and CH2; Y is selected from the group consisting of CH2 and CH as part of an olefin; X is selected from the group consisting of CH2, CH as part of an olefin, NR3, S and O; with the proviso that if Y is CH as part of an olefin, then X is CH as part of an olefin; Z is selected from the group consisting of N and CH; R1 is one to two substituents independently selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, aminoalkyl, oxo and nitro; Ar is selected from naphthyl, wherein naphthyl is optionally substituted with from one to four substituents independently selected from C1-C8 alkyl, C1-C8 alkoxy, fluorinated C1-C8 alkyl, fluorinated C1-C8 alkoxy, halogen, cyano, hydroxy, amino, nitro, C1-C4 alkylamino or C1-C4 dialkylamino (wherein the alkyl groups on the amino may be the same or different); or phenyl, wherein phenyl is optionally substituted with from one to four substituents independently selected from C1-C8 alkyl, C1-C8 alkoxy, fluorinated C1-C8 alkyl, fluorinated C1-C8 alkoxy, C1-C8 aralkyl (wherein optionally the alkyl or aryl portions are independently substituted and the alkyl portion may be substituted with at least one fluorine and/or the aryl portion may be independently substituted with from one to two substituents selected from halogen, C1-C4 alkyl, C1-C6 alkylthio or hydroxyl), C1-C8 aralkoxy (wherein optionally the alkoxy or aryl portions are independently substituted and the alkoxy portion may be substituted with at least one fluorine and/or the aryl portion may be independently substituted with from one to two substituents selected from halogen, C1-C4 alkyl, C1-C6 alkylthio or hydroxyl), halogen, cyano, hydroxy, amino, nitro, C1-C8 alkylamino, C1-C4 dialkylamino (wherein the alkyl groups on the amino may be the same or different), (halo)1-3(C1-C8)alkylthio, C1-C8 alkylsulfonyl, C1-C8 alkylthio, C1-C8 alkylsulfinyl, heteroaryl (optionally substituted with one to two substituents independently selected from C1-C8 alkyl) or phenyl (optionally substituted with from one to two substituents independently selected from C1-C4 alkyl, C1-C4 alkoxy, fluorinated C1-C4 alkyl, fluorinated C1-C4 alkoxy, halogen, cyano, hydroxy, amino, nitro, C1-C4 alkylamino, C1-C4 dialkylamino (wherein the alkyl groups on the amino may be the same or different), C1-C4 alkylsulfonyl, C1-C4 alkylthio, or C1-C4 alkylsulfinyl); R2 is selected from the group consisting of NR4COAr, NR4CO-heteroaryl, NR4Ar, CH&boxH;CHâ€”Ar, CF&boxH;CHâ€”Ar, CH&boxH;CFâ€”Ar, CCl&boxH;CHâ€”Ar, CH&boxH;CClâ€”Ar, CH&boxH;CH-heteroaryl, CF&boxH;CH-heteroaryl, CH&boxH;CF-heteroaryl, â€”CCl&boxH;CH-heteroaryl, CH&boxH;CCl-heteroaryl, OCH2â€”Ar, OCH2-heteroaryl, SCH2â€”Ar and NR4CH2Ar; R3 is selected from the group consisting of hydrogen, acyl, alkyl, alkoxycarbonyl, alkylsulfonyl and arylsulfonyl; R4 is selected from the group consisting of hydrogen and C1-C4 alkyl; R5 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkoxy, chlorine, fluorine, hydroxy, dialkylamino (wherein the alkyl groups on the amino may be the same or different), trifluoromethyl and trifluoromethoxy; and pharmaceutically acceptable salts thereof.