Patent ID: 6784192
Filing Date: 2004-08-31
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (I), a salt thereof or a hydrate of them: wherein in formula (I), the ring A is a ring represented by the formula: wherein R1 is (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) an optionally substituted C1-6 alkyl group, (5) an optionally substituted C2-6 alkenyl group, (6) an optionally substituted C2-6 alkynyl group, (7) an optionally substituted C3-8 cycloalkyl group, (8) an optionally substituted C3-8 cycloalkenyl group, (9) an optionally substituted C1-6 alkoxy group, (10) an optionally substituted C1-6 alkylthio group, (11) an optionally substituted C1-6 alkylsulfinyl group, (12) an optionally substituted C1-6 alkylsulfonyl group, (13) an optionally substituted C1-14 aromatic hydrocarbon cyclic group or (14) an optionally substituted 5- to 14-membered aromatic heterocyclic group; R2 is (1) a hydrogen atom, (2) an optionally substituted C1-6 alkyl group, (3) an optionally substituted C2-6 alkenyl group, (4) an optionally substituted C2-6 alkynyl group, (5) an optionally substituted C3-8 cycloalkyl group, (6) an optionally substituted C3-8 cycloalkenyl group, (7) an optionally substituted amino group, (8) an additional substituted C5-14 aromatic hydrocarbon cyclic group or (9) an optionally substituted 5- to 14-membered aromatic heterocyclic group; and R3 is (1) an optionally substituted C1-6 alkoxy group, (2) an optionally substituted C2-6 alkenyloxy group, (3) an optionally substituted C3-7 cycloalkyloxy group or (4) an optionally substituted C3-7 cycloalkenyloxy group; W is (1) a single bond, (2) an optionally substituted C1-6 alkylene group, (3) an optionally substituted C2-6 alkenylene group, (4) an optionally substituted C2-6 alkynylene group or (5) a group represented by the formula â€”Uâ€”Vâ€” (wherein U is (i) a single bond, (ii) an oxygen atom, (iii) a sulfur atom, (iv) a group represented by the formula â€”NHâ€”, (v) an optionally substituted C1-6 alkylene group, (vi) an optionally substituted C2-6 alkenylene group or (vii) an optionally substituted C2-6 alkynylene group; V is (i) a single bond, (ii) an optionally substituted C1-6 alkylene group, (iii) an optionally substituted C2-6 alkenylene group, (iv) an optionally substituted C2-6 alkynylene group, (v) an oxygen atom, (vi) a sulfur atom, or (vii) a group represented by the formula â€”COâ€”, (viii) â€”SOâ€” or (ix) â€”SO2â€”, provided that the case where U and V mean the same group in the above definition is excluded, and one of U and V is a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group or an optionally substituted C2-6 alkynylene group); Z is (1) an optionally substituted C6-14 aromatic hydrocarbon cyclic group, (2) an optionally substituted 5- to 14-membered aromatic heterocyclic group or (3) a group represented by the formula â€”N(R4)R5 (wherein R4 and R5 may be the same as or different from each other and each represents (i) a hydrogen atom, (ii) an optionally substituted C1-6 alkyl group, (iii) an optionally substituted C2-6 alkenyl group, (iv) an optionally substituted C2-6 alkynyl group, (v) an optionally substituted C3-8 cycloalkyl group, (vi) an optionally substituted C3-8 cycloalkenyl group, (vii) an optionally substituted C6-14 aromatic hydrocarbon cyclic group, (viii) an optionally substituted 5- to 14-membered aromatic heterocyclic group or (ix) a C1-6 aliphatic acyl group, with the proviso that Z is not â€”NH2); and l represents an integer of 0 to 6.