Patent ID: 8436040
Filing Date: 2013-05-07
Classification: A61P,C07D

Abstract:
1. A method of treating a condition selected from the group consisting of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, dyslipidemia, obesity, insulin resistence, diabetes, atherosclerosis, myocardial infarction, hypertension, cerebral vascular disease, rheumatoid arthritis, Alzheimer's disease, and Parkinson's disease in a subject in need thereof, said method comprising administering to said subject a pharmacologically effective amount of a compound corresponding to formula I: wherein R R R R is hydrogen or C n is 1, 2or 3; X is a single bond, an oxygen atom or a sulfur atom; and Ar is an aromatic or heteroaromatic ring selected from the group consisting of phenyl, naphthyl, quinolinyl, isoquinolinyl, pyridinyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, benzimidazolyl, benzothiazolyl, 2,1,3-benzothiadiazolyl, 3,4-dihydro-1,4-benzoxazinyl, 5,6,7,8-tetrahydronaphthalenyl, 1,2,3,4-tetrahydroquinolinyl, 1,2,3,4-tetrahydroiso-quinolinyl, 1,2,3,4-tetrahydro-2-oxoquinolinyl, 3,4-dihydro-2H-benzopyranyl, indolyl, 2,3-dihydroindolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxanyl and benzoxazolyl optionally substituted by one or more substituents selected from the group consisting of halogen, C or a pharmaceutically acceptable salt thereof.