Patent ID: 8426145
Filing Date: 2013-04-23
Classification: A61K,C07D,C07K,G01N

Abstract:
1. A method for diagnosing Celiac Sprue in an individual, said method comprising detecting the presence of a multivalent oligopeptide selected from the group consisting of (SEQ ID NO:12) LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF or a deamidated counterpart thereof; and a gluten oligopeptide or a deamidated counterpart thereof, having the formula: wherein E 1 , E 2 and E 3 are independently selected T cell recognition epitopes that, when contained in a peptide, can stimulate T cell proliferation in an individual with Celiac Sprue, X 1 and X 2 are independently selected from the group consisting of a peptide bond and at least one amino acid, n=1-5, and y=0-5, in a tissue, bodily fluid, or stool of said individual.