Patent ID: 6355643
Filing Date: 2002-03-12
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula D: wherein:R1a and R1b are independently selected from: a) hydrogen, b) â€”N(R10)2, c) C1-C6 alkyl unsubstituted or substituted by phenyl, R10Oâ€”, or â€”N(R10)2; R3 is selected from H and CH3; R2 is selected from H; â€ƒor C1-5 alkyl, unbranched or branched, unsubstituted or substituted with one or more of: 1) aryl, 2) OR6, 3) SR6a, SO2R6a, or 4) â€ƒand R2 and R3 are optionally attached to the same carbon atom; R6 and R7 are independently selected from: H; C1-4 alkyl, C3-6 cycloalkyl, aryl, unsubstituted or substituted with: a) C1-4 alkoxy, b) halogen, or c) phenyl, pyndyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, thienyl, furyl or isothiazolyl; R6a is selected from: C1-4 alkyl or C3-6 cycloalkyl, unsubstituted or substituted with: a) C1-4 alkoxy, b) halogen, or c) phenyl, pyridyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, thienyl, furyl or isothiazolyl; R8 is independently selected from: a) hydrogen, b) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 perfluoroalkyl, F, Cl, R10Oâ€”, R10C(O)NR10â€”, CN, NO2, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, â€”N(R10)2, or R11OC(O)NR10â€”, and c) C1-C6 alkyl substituted by C1-C6 perfluoroalkyl, R10Oâ€”, R10C(O)NR10â€”, (R10)2Nâ€”C(NR10)â€”, R10C(O)â€”, â€”N(R10)2, or R11OC(O)NR10â€”; R9a is hydrogen or methyl; R10 is independently selected from hydrogen, C1-C6 alkyl, benzyl and aryl; R11is independently selected from C1-C6 alkyl and aryl; A1 is selected from: a bond, â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”C(O)â€”, â€”C(O)NR10â€”, O, â€”N(R10)â€”, or S(O)m; A3 is selected from: â€”C(O)â€”, â€”C(O)NR10â€” or â€”C(O)Oâ€”, V is selected from: a) pyridinyl or quinolinyl, and b) aryl; Z is unsubstituted or substituted C5-C10 alkyl, wherein the substituted C5-C10 alkyl is substituted with one or two moieties selected from the following: a) C1-4 alkoxy, b) NR6R7, c) C3-6 cycloalkyl, d) â€”NR6C(O)R7, e) â€”OR10, f) â€”S(O)mR6a, g) halogen, or h) perfluoroalkyl; aryl is selected from: phenyl, naphthyl, tetrahydronaphthyl, indanyl and biphenyl; m is 0, 1 or 2; n is 0, 1 or 2; p is 0, 1, 2 or 3; and r is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.