Patent ID: 7250153
Filing Date: 2007-07-31
Classification: A61K

Abstract:
1. A formulation having improved biological tolerance and a physiologically acceptable pH and osmolality comprising a sterile aqueous solution of iosimenol (1-N,N′-Bis[3-carbamoyl-5-(2,3-dihydroxypropyl-carbamoyl)-2,4,6-triiodophenyl]-N,N′-bis(2,3-dihydroxypropyl)-malonamide); and a buffer comprising: TRIS and citrate, wherein the molar ratio of TRIS to citrate is in the range of greater than 3:1 to about 10:1 and said TRIS is at a concentration in the range of about 5 to 40 mM.