Patent ID: 6465483
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of formula I whereinA is a benzo; wherein, m is 2 or 3 and the substituents R2 independently of each other are hydroxy, (C1-4)alkoxy, halogen, (C1-4)alkyl, methanesulphonyloxy or methanesulphonamido, or two adjacent substituents R2 may together be â€”Oâ€”CH2â€”Oâ€” or â€”Oâ€”CH2â€”CH2â€”Oâ€”; R1 is thienyl; R3 and R4 independently of each other have one of the following meanings: (a) hydrogen, (b) branched or unbranched C3-6-alkenyl, (c) branched or unbranched C3-6-alkynyl, or (d) branched or unbranched C1-2-alkyl, wherein the alkyl is optionally substituted by hydroxy, (C1-4)alkoxy, di(C1-4)alkylamino, furyl, pyridyl, pyrrolidinyl, N-methylpyrrolidinyl, morpholino, indolyl, nitrilo, thienyl, adamantyl, cyclohexyl, phenoxy, naphthyloxy or phenyl, wherein this phenyl or the phenyl contained in the phenoxy group is optionally mono-, di- or trisubstituted by hydroxy, (C1-4)alkoxy, benzyloxy, halogen, CF3, N3, CN, (C1-4)alkyl, adamantyl, â€”SO2NH2, â€”NHCOCH3, â€”NHSO2CH3 or CH3SO2Oâ€” or by the bridge â€”Oâ€”CH2â€”Oâ€”; or by two unsubstituted phenyl groups; or R3 is hydrogen and R4 is cyclohexyl, phenyl wherein this phenyl is optionally mono-, di- or trisubstituted by hydroxy, (C1-4) alkoxy, benzyloxy, halogen, CF3, N3, (C1-4)alkyl, adamantyl, â€”SO2NH2, â€”NHCOCH3, â€”NHSO2CH3 or CH3SO2Oâ€” or by the bridge â€”Oâ€”CH2â€”Oâ€”; or R3 is hydrogen and R4 is pyridyl or N-benzylpiperidyl; or R3 and R4 together with the nitrogen atom to which they are bound are pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl or piperazinyl, wherein the piperazinyl ring is optionally N-substituted by methyl, unsubstituted phenyl, mono- or di(C1-4)alkoxyphenyl, cyano-substituted phenyl, pyrimidinyl, phenyl(C1-4)alkyl, (C1-4)alkylphenyl or or the salts thereof with physiologically acceptable acids or complex-forming agents.