Patent ID: 7217430
Filing Date: 2007-05-15
Classification: A61K

Abstract:
1. A composition comprising amoxicillin and potassium clavulanate in a dosage of 2000 mg of amoxicillin and 125 mg of potassium clavulanate, wherein the composition is in a solid form and comprises a first release phase and a second release phase; the first release phase comprising potassium clavulanate and a first amount of the amoxicillin; and the second release phase comprising a second amount of the amoxicillin in the form of a soluble salt at about 60–80% of the second phase, a pharmaceutically acceptable organic acid in a molar ratio of 50:1 to 1:5 (amoxicillin to organic acid), and a reduced amount of a pharmaceutically acceptable release retarding polymer which is xanthan gum at about 1–5% of the second phase; wherein the composition provides a mean maximum plasma concentration (Cmax) of amoxicillin of at least 12 μg/ml.