Patent ID: 8058248
Filing Date: 2011-11-15
Classification: A61K,A61P,C12N

Abstract:
1. An early-acting effective anti-foot-and mouth disease virus vaccine suitable for administering intramuscularly to animals, said vaccine comprising an effective amount of: a nucleic acid construct which is a DNA sequence which is capable of expressing an interferon-α protein of cloven-hooved animal origin and/or an interferon-β protein of porcine origin in animals susceptible to foot and mouth disease, and an additional nucleic acid construct which is a DNA sequence which encodes all the viral structural proteins and the 3C proteinase of a foot and mouth disease virus (FMDV) and which is capable of expressing said structural proteins and 3C proteinase in animals susceptible to foot and mouth disease, wherein said structural proteins stimulate an immune response when administered to said animals, and wherein said interferon-α and/or interferon-β protein is expressed prior to development of specific immunity to said structural proteins and 3C proteinase.