Patent ID: 6670371
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof whereinE represents CH or nitrogen; R3 and R4 are not both hydrogen and independently represent hydrogen, lower alkyl, phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl or 2-, 4-, or 5-pyrimidinyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, lower alkyl, or lower alkoxy; phenylalkyl, 2-, 3-, or 4-pyridylalkyl, 2- or 3-thienylalkyl, or 2-, 4-, or 5-pyrimidinylalkyl, where each alkyl is lower alkyl, or cycloalkyl having 3-8 carbon atoms, cycloalkyl lower alkyl, 2-hydroxyethyl or 3-hydroxyproply, each of which is optionally mono or disubstituted with lower alkyl; and R5 is lower alkyl.