Patent ID: 6066447
Filing Date: 2000-05-23
Classification: A61P,C07H

Abstract:
An oligonucleotide of the formula I5'-(U).sub.n -3' (I),in which U is an identical or different radical of a natural or a synthetic nucleoside and n is a number from 2 to 200 comprising at least one structural unit of two consecutive nucleosides, the structural unit comprising the formula IIa ##STR116## wherein R.sub.1 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;R.sub.2 is H; C.sub.1 -C.sub.4 alkyl; phenyl; phenyl substituted with Oh, OR'"", O(CH.sub.2 CH.sub.2 O).sub.n R'"", C.sub.6 -C.sub.10 aryl or C.sub.3 -C.sub.9 heteroaryl; an intercalator; amino-C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 alkylamino; ammonium-C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 alkylammonium; amino-C.sub.1 -C.sub.r alkylaminosulfonyl; C.sub.1 -C.sub.4 alkylamino-C.sub.1 -C.sub.4 alkylaminosulfonyl; or(CH.sub.3).sub.2 NCH.sub.2 CH.sub.2 ;R.sub.3 is H or C.sub.1 -C.sub.4 alkyl;R'"" is C.sub.1 -C.sub.4 alkyl;X is H, OH, O--C.sub.1 -C.sub.4 alkyl, --O--(CH.sub.2 --CH.sub.2 --O).sub.m H or --O--CH.sub.2 --C(OR)H--CH.sub.2 --OH;Y is H, O--C.sub.1 -C.sub.4 alkyl, --O--(CH.sub.2 --CH.sub.2 --O).sub.m H or --O--CH.sub.2 --(OR)H--CH.sub.2 --OH;r is H or C.sub.1 -C.sub.10 alkyl;m is an integer from 1 to 4;n is an integer from 1 to 4 andB is a purine or pyrimidine radical with the proviso that either X or Y is H and that X and Y are not identical.