Patent ID: 6030984
Filing Date: 2000-02-29
Classification: C07D

Abstract:
A compound of the formula ##STR5## wherein R.sup.3 and R.sup.4 each represent hydrogen or together represent one of the groups --S--CH.dbd.CH--, --CH.dbd.CH--S--, --CH.dbd.CH--CH.dbd.CH--, --CH.dbd.CCl--CH.dbd.CH--, --N.dbd.CHN(CH.sub.3)--, --S--C[CH(OH)(CH.sub.3)].dbd.CH--, --S--C(carbamoyl).dbd.CH--, --S--C(halogen).dbd.CH--, --S--C[C(O)OH].dbd.CH--, --S--C(lower-alkyl).dbd.CH-- or --NH(o-phenylene);R.sup.5 represents hydrogen, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy, lower-alkoxy-alkyl, phenyl optionally substituted by lower-alkoxy, hydroxyalkyl, cycloalkyl optionally substituted by hydroxy or lower-alkoxy, benzyl optionally substituted by di-lower-alkylaminoalkyl, lower-alkanoyldialkylamino, lower-alkynyldialkylamino, lower-alkenyldialkylamino, lower-alkyldialkylamino or a saturated or aromatic 4 to 6-membered ring with at least one N, O and/or S atom, or a saturated or aromatic bicyclic residue with optionally 1-3 hetero atoms, with the rings being bonded directly or via an alkylene, alkenylene or alkynylene group and being optionally substituted by one or more substituents from lower-alkyl, lower-alkoxy, hydroxy, oxo, benzyloxycarbonyl or lower-alkanoyloxyalkyl;R.sup.6 signifies hydrogen, lower-alkyl, lower-alkoxy-alkyl, cycloalkyl-lower-alkyl, phenyl, benzyl or lower-alkoxy, and wherein whenQ.sup.1 is NR.sup.6, R.sup.5 and R.sup.6 together can form a 4-6-membered saturated or aromatic heterocyclic ring with 1-2 N atoms, which is optionally substituted by one or more substituents selected from lower-alkoxy, lower-alkoxyalkyl, lower-hydroxyalkyl, hydroxy, halogen, lower-haloalkyl, lower-alkanoyloxyalkyl, lower-alkyl, haloalkyl or oxo; andR.sup.7 signifies hydrogen or halogen;and Y signifies a bond, --O--, --O-lower-alkyl or lower-alkyl-O--,as well as their pharmaceutically acceptable salts.