Patent ID: 6313305
Filing Date: 2001-11-06
Classification: C07C,C07D,Y02P

Abstract:
A compound having the formula selected from the group consisting of ##STR479##wherein either R.sub.3p and R.sub.4p are identical and selected from the group consisting of --OH and protected --OH, R.sub.2p is selected from the group consisting of --CN, --F, Br and I and R.sub.1p and R.sub.5p are hydrogen or R.sub.5p is --F and R.sub.1p and R.sub.2p are hydrogen or R.sub.1p and R.sub.2p are F and R.sub.5p is hydrogen, or R.sub.4p and R.sub.5p are identical, and selected from the group consisting of --OH and protected --OH, R.sub.3p is selected from the group consisting of F and --CN and R.sub.1p and R.sub.2p are hydrogen, R.sub.8 is hydrogen or an amine protective group and R.sub.10 is the remainder of an easily cleavable ester and R.sub.7p is K or L in which the hydroxy or amino are protected ##STR480##wherein R'.sub.1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, --CN, carboxy and alkoxy carbonyl of 1 to 4 carbon atoms.