Patent ID: 6663847
Filing Date: 2003-12-16
Classification: C07D

Abstract:
A method for performing a diagnostic or therapeutic procedure comprising administering to a mammal an effective amount of the indole of formula wherein R16, R17, R18, R20, R21, R22 and R23, Y3, and Z3 are independently selected from the group consisting of â€”H, C1-C10 alkoxyl, C1-C10 polyalkoxyalkyl, C1-C20 polyhydroxyalkyl, C5-C10 polyhydroxyaryl, saccharides, amino, C1-C10 aminoalkyl, cyano, nitro, halogen, hydrophilic peptides, arylpolysulfonates, C1-C10 alkyl, C5-C20 aryl, â€”SO3T, â€”CO2T, â€”OH, â€”(CH2)aSO3T, â€”(CH2)aOSO3T, â€”(CH2)aNHSO3T, â€”(CH2)aCO2(CH2)bSO3T, â€”(CH2)aOCO(CH2)bSO3T, â€”(CH2)aCONH(CH2)bSO3T, â€”(CH2)aNHCO(CH2)bSO3T, â€”(CH2)aNHCONH(CH2)bSO3T, â€”(CH2)aNHCSNH(CH2)bSO3T, â€”(CH2)aOCONH(CH2)bSO3T, â€”(CH2)aPO3HT, â€”(CH2)aPO3T2, â€”(CH2)aOPO3HT, â€”(CH2)aOPO3T2, â€”(CH2)aNHPO3HT, â€”(CH2)aNHPO3T2, â€”(CH2)aCO2(CH2)bPO3HT, â€”(CH2)aCO2(CH2)bPO3T2, â€”(CH2)aOCO(CH2)bPO3HT, â€”(CH2)aOCO(CH2)bPO3T2, â€”(CH2)aCONH(CH2)bPO3HT, â€”(CH2)aCONH(CH2)bPO3T2, â€”(CH2)aNHCO(CH2)bPO3HT, â€”(CH2)aNHCO(CH2)bPO3T2, â€”(CH2)aNHCONH(CH2)bPO3HT, â€”(CH2)aNHCONH(CH2)bPO3T2, â€”(CH2)aNHCSNH(CH2)bPO3HT, â€”(CH2)aNHCSNH(CH2)bPO3T2, â€”(CH2)aOCONH(CH2)bPO3HT, and â€”(CH2)aOCONH(CH2)bPO3T2, â€”CH2(CH2â€”Oâ€”CH2)câ€”CH2â€”OH, â€”(CH2)dâ€”CO2T, â€”CH2â€”(CH2â€”Oâ€”CH2)eâ€”CH2â€”CO2T, â€”(CH2)fâ€”NH2, â€”CH2â€”(CH2â€”Oâ€”CH2)gâ€”CH2â€”NH2, â€”(CH2)hâ€”N(Ra)â€”(CH2)iâ€”CO2T, and â€”(CH2)jâ€”N(Rb)â€”CH2â€”(CH2â€”Oâ€”CH2)kâ€”CH2â€”CO2T; R15 is selected from the group consisting of â€”(CH2)aSO3T, â€”(CH2)aOSO3T, â€”(CH2)aNHSO3T, â€”(CH2)aCO2(CH2)bSO3T, â€”(CH2)aOCO(CH2)bSO3T, â€”(CH2)aCONH(CH2)bSO3T, â€”(CH2)aNHCO(CH2)bSO3T, â€”(CH2)aNHCONH(CH2)bSO3T, â€”(CH2)aNHCSNH(CH2)bSO3T, and â€”(CH2)aOCONH(CH2)bSO3T; R19 is selected from the group consisting of â€”H, C5-C10 alkoxyl, C5-C10 polyalkokyalkyl, C7-C20 polyhydroxyalkyl, C5-C20 polyhydroxyaryl, saccharides, amino, C1-C10 aminoalkyl, cyano, nitro, halogen, hydrophilic peptides, arylpolysulfonates, C7-C10 alkyl, C5-C20 aryl, â€”SO3T, â€”CO2T, â€”OH, â€”(CH2)aSO3T, â€”(CH2)aOSO3T, â€”(CH2)aNHSO3T, â€”(CH2)aCO2(CH2)bSO3T,(CH2)aOCO(CH2)bSO3T, â€”(CH2)aCONH(CH2)bSO3T, â€”(CH2)aNHCO(CH2)bSO3T, â€”(CH2)aNHCONH(CH2)bSO3T, â€”(CH2)aNHCSNH(CH2)bSO3T, â€”(CH2)aOCONH(CH2)bSO3T, â€”(CH2)aPO3HT, â€”(CH2)aPO3T2, â€”(CH2)aOPO3HT, â€”(CH2)aOPO3T2, â€”(CH2)aNHPO3HT, â€”(CH2)aNHPO3T2, â€”(CH2)aCO2(CH2)bPO3HT, â€”(CH2)aCO2(CH2)bPO3T2, â€”(CH2)aOCO(CH2)bPO3HT, â€”(CH2)aOCO(CH2)bPO3T2, â€”(CH2)aCONH(CH2)bPO3HT, â€”(CH2)aCONH(CH2)bPO3T2, â€”(CH2)aNHCO(CH2)bPO3HT, â€”(CH2)aNHCO(CH2)bPO3T2, â€”(CH2)aNHCONH(CH2)bPO3HT, â€”(CH2)aNHCONH(CH2)bPO3T2, â€”(CH2)aNHCSNH(CH2)bPO3HT, â€”(CH2)aNHCSNH(CH2)bPO3T2, â€”(CH2)aOCONH(CH2)bPO3HT, and â€”(CH2)aOCONH(CH2)bPO3T2, â€”CH2(CH2â€”Oâ€”CH2)câ€”CH2â€”OH, â€”(CH2)dâ€”CO2T, â€”CH2â€”(CH2â€”Oâ€”CH2)eâ€”CH2â€”CO2T, â€”(CH2)fNH2, â€”CH2â€”(CH2â€”Oâ€”CH2)gâ€”CH2â€”NH2, â€”(CH2)hâ€”N(Ra)â€”(CH2)iâ€”CO2T, and â€”(CH2)jâ€”N(Rb)â€”CH2â€”(CH2â€”Oâ€”CH2)kâ€”CH2â€”CO2T; W3 and X3 are selected from the group consisting of â€”CRcRd, â€”Oâ€”, â€”NRc, â€”Sâ€”, and â€”Se; V3 is a single bond or is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”Seâ€”, and â€”NRa; a, b, d, f, h, i, and j independently vary from 1-10; c, e, g, and k independently vary from 1-100; a3 and b3 vary from 0 to 5; Ra, Rb, Rc, and Rd are defined in the same manner as Y3; and T is either H or a negative charge.