Patent ID: 6147189
Filing Date: 2000-11-14
Classification: A61K,C07K

Abstract:
A method of producing a conformationally-constrained polypeptide that mimics the activity of an RGD-containing peptide, wherein the method comprises:synthesizing the conformationally-constrained polypeptide, wherein the conformationally-constrained polypeptide contains a RGD interaction site of said RGD-containing peptide adjacently flanked on both termini by proline residues in a manner distinct from the manner found in the RGD-containing peptide, wherein the conformationally-constrained polypeptide contains an amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9.