Patent ID: 8426365
Filing Date: 2013-04-23
Classification: A61K,A61P

Abstract:
1. A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to heart failure disease in a subject with heart failure, or for restoring heart tissue adversely affected in said subject by heart failure, comprising administering to said subject with heart failure an effective amount of a composition comprising a peptide agent comprising amino acid sequence LKKTET (SEQ ID NO: 1) or a conservative variant thereof, LKKTNT (SEQ ID NO: 2) or a conservative variant thereof, Thymosin β4 (Tβ4), a Tβ4 isoform, KLKKTET (SEQ ID NO: 3), LKKTETQ (SEQ ID NO: 4), oxidized Tβ4, an N-terminal variant of Tβ4, a C-terminal variant of Tβ4, Tβ4 ala , Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DNasel, vilin, fragmin, severin, capping protein, β-actinin or acumentin, in said tissue, so as to inhibit said tissue deterioration, injury or damage due to said disease or restore tissue adversely affected by said disease.