Patent ID: 6509324
Filing Date: 2003-01-21
Classification: A61K,C07F,C07J,Y10S

Abstract:
A compound having the formula (I), in the racemic or in the optically active form, or a pharmaceutically acceptable salt thereofwherein:each Y group is independently a COOH group or a PO(OH)2 group, with the proviso that at least one Y group is &boxH;PO(OH)2, R is a hydrogen atom, or â€”(CH2)mâ€”Oâ€”R2, (C1-C5)-alkyl-(C6-C10)-aryl or (C1-C5)-alkyl-heteroaryl whose aryl or heteroaryl moiety comprises 1 or 2 fused rings optionally substituted with one or more halogen atoms, OH groups, (C1-C5)alkyl groups and/or an OR3 group, wherein R2 is (C1-C5)-alkyl-(C6-C10)-aryl, optionally substituted with one or more halogen atoms, OH and (C1-C5)-alkyl groups; R3 is (C6-C10) aryl optionally substituted with one or more halogen atoms, OH and/or (C1-C5)-alkyl groups; m ranges from 1 to 5; R1 can have the same meanings as R with the proviso that when the Y group attached to the same carbon atom as R1 is PO(OH)2, R1 is selected from H, (CH2)mNH2, or (CH2)mCOOH or an amido derivative thereof, and with the proviso that when at least two of the three Y groups are PO(OH)2, the two R groups and R1 cannot be contemporaneously H.