Patent ID: 7291616
Filing Date: 2007-11-06
Classification: A61P,C07D

Abstract:
1. A method for treating a prostate, breast, lung, ovarian, brain, cervical, colon or bladder cancer in which lysophosphatidic acid acyltransferase β (LPAAT-β) activity is associated comprising administering to an animal in need, a compound or salt thereof, or in combination with a pharmaceutically acceptable carrier or diluent, in an amount effective to treat said cancer, wherein the compound is any one of compounds 6-(5-Chloro-2-methoxyphenyl)-N-(4-chlorophenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methoxyphenyl)-N-phenyl-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methoxyphenyl)-N-(4-nitrophenyl)-[1,3,5]triazine-2,4-diamine; N-Benzo[1,3]dioxol-5-yl-6-(5-chloro-2-methoxyphenyl-[1,3,5]triazine-2,4-diamine; N-(4-Chlorophenyl)-6-(2-fluoro-5-methoxyphenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-ethoxyphenyl)-N-(4-Chlorophenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methoxyphenyl)-N-(3,4-dichlorophenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methylphenyl)-N-(4-Chlorophenyl)-[1,3,5]triazine-2,4-diamine; N-2-(4-Bromophenyl)-6-(5-chloro-2-methoxyphenyl)-[1,3,5]triazine-2,4-diamine; N-2-(4-Bromophenyl)-6-(5-chloro-2-methylphenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-chloro-2-methyl-phenyl)-n-(1h-indazol-6-yl)-[1,3,5]triazine-2,4-diamine; N-(4-chlorophenyl)-6-(2,5-dimethylphenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-chloro-2-methoxyphenyl)-N-(4-fluorophenyl)-[1,3,5]triazine-2,4-diamine; N-(4-chlorophenyl)-6-(3-chlorophenyl)-[1,3,5]triazine-2,4-diamine; N-(4-chlorophenyl)-6-(2,5-dimethoxyphenyl)-[1,3,5]triazine-2,4-diamine; Poly-(L-glutamic acid) conjugate of 4-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]-triazin-2-ylamino]-phenyl}-methanol; N-Benzo[1,3]dioxol-5-yl-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine-2,4-diamine; (4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-yl]-amine; (4-Bromo-phenyl)-[4-(5-chloro-2-methyl-phenyl)-6-methoxy-[1,3,5]triazin-2-yl-amine; [4-(5-Chloro-2-methyl-phenyl)-6-methyl-[1,3,5]triazin-2-yl]-(1H-indazol-6-yl)-amine; (4-Bromo -phenyl)-[4-(5-chloro-2-methyl-phenyl)-6-methyl-[1,3,5]triazin-2-yl-amine; (4-Bromo-phenyl)-[4-(5-chloro-2-methyl-phenyl)-6-ethyl-[1,3,5]triazin-2-yl-amine; 6-(5-Chloro-2-methyl-phenyl) -N-(4-chloro-phenyl)-N-methyl-[1,3,5]triazine-2,4-diamine; [4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-yl]-(1H-indazo1-6-yl)-amine; [2-Aminimethyl-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-4-yl]-(4-bromo-phenyl)-amine; 6-(5-Chloro-2-methyl-phenyl)-(4-bromo-phenyl)-[1,3,5]-triazine-2-carbonitrile; (4-Bromo-phenyl)-[4-(5-chloro-2-methyl-phenyl)-6-methylsulfanyl-[1,3,5]triazin-2-yl]-amine; [6-(5-Chloro-2-methyl-phenyl)-2-chloro-3-yl-[1,3,5]-triazin-4-yl]-(4-nitro-phenyl)-amine; [6-(5-Chloro-2-methyl-phenyl)-2-piperidin-3-yl-[1,3,5]triazin-4-yl]-(4-chloro-phenyl)-amine; 6-(5-Chloro-2-methyl-phenyl)-N-(4-chloro-phenyl)-N,N-dimethy-[1,3,5]triazine-2,4-diamine; [6-(5-Chloro-2-methyl-phenyl)-[1,3,5]triazin-4-yl]-(4-chloro-phenyl)-amine; N-(4-Chloro-3-methylamino-phenyl)-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine-2,4-diamine; [6-(5-Chloro-2-methyl-phenyl)-2-chloro-3-yl-[1,3,5]-triazin-4-yl]-(4-azido-phenyl)-amine; 6-(5-Chloro-2-methyl-phenyl)-N-(4-azido-phenyl)-amino-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N-indan-5-yl-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N-(4-ethyl-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N-p-tolyl-[1,3,5]triazine-2,4-diamine; N-(4-bromophenyl)-6-(5-chloro-2-trifluoromethylphenyl)-[1,3,5]triazine-2,4-diamine; {4-[4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-phenyl}-methanol; 6-(5-Chloro-2-methyl-phenyl)-N-(4-ethynyl-phenyl)-[1,3,5]triazine-2,4-diamine; 5-[4-amino-6-(5-chloro-2-methylphenyl)-[1,3,5]triazin-2-ylamino]-2-chloro-N-methylbenzamide; 6-(5-chloro-2-methylaminophenyl)-N-(4-chlorophenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Bromo-2-chloro-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-chloro-2-dimethylaminophenyl)-N-(4-chlorophenyl)-[1,3,5]triazine-2,4-diamine; N-(4-Chloro-phenyl)-6-(5-chloro-2-propoxy-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-ethoxy-phenyl)-N-(1H-indazol-6-yl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-isopropoxy-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; {4-[4-Amino-6-(5-chloro-2-ethoxy-phenyl)[1,3,5]triazin-2-ylamino]-phenyl}-methanol; 6-(5-chloro-2-ethoxyphenyl)-N-(4-nitrophenyl)-[1,3,5]triazine-2,4-diamine; N-Benzo[1,3]dioxol-5-yl-6-(5-chloro-2-ethoxy-phenyl)[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-ethoxyphenyl)-N-(4-nitrophenyl)-[1,3,5]triazine-2,4-diamine; 2-{4-[4-Amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-phenyl}-ethanol; 6-(5-Chloro-2-methyl-phenyl)-N-(4-dimethylaminomethyl-phenyl)-[13,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N -(3,4-dimethyl-phenyl)-[1,3,5]triazine-2,4-diamine; {4-[4-Amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-phenyl}-acetic acid; 6-(5-Chloro-2-ethoxyphenyl)-N-p-tolyl-[1,3,5]triazine-2,4-diamine; 5-[4-amino-6-(5-chloro-2-ethoxyphenyl)-[1,3,5]triazin-2-ylamino]-2-chloro-N-methylbenzamide; (S)-2-Amino-pentanedioic acid 5-{4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5 ]triazin-2-ylamino]-benzyl}ester; (S)-2-Amino-pentanedioic acid 1-{4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]-triazin-2-ylamino]-benzyl}ester; 6-[5-Chloro-2-(2-methoxy-ethoxy)-phenyl]-N-(4-chloro-phenyl)[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N-(3-ethyl-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl) -N-(4-vinyl-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methyl-phenyl)-N-(4-fluoromethyl-phenyl)-[1,3,5]-triazine-2,4-diamine; 1-{4-[4-Amino-6-(5-chloro-2-ethoxy-phenyl)-)-[1,3,5]triazin-2-ylamino]-phenyl}-ethane-1,2-diol; Succinic acid mono-{4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzyl ester; Amino-acetic acid 4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2ylamino]-benzyl ester; (S)-2-Amino-succinic acid 1-{4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzyl}ester; (S)-2-Amino-succinic acid 4-{4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzyl}ester; (4-[4-(5-Chloro-2-methyl-phenyl)-6-methylamino-[1,3,5]-triazin-2-ylamino]-phenyl}-methanol; (S)-2-Amino-5-guanidino-pentanoic acid 4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzyl ester; (S)-Pyrrolidine-2-carboxylic acid 4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzyl ester; 2-Amino-propionic acid 4-[4-amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]-triazin-2-ylamino]-benzyl ester; 6-(5-Chloro-2-methyl-phenyl)-N-(4-methoxy-methyl-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(5-Chloro-2-methoxy-phenyl)-N-p-tolyl-[1,3,5]triazine-2,4-diamine; 6-(2-Bromo-5-chloro-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; N-(4-Chloro-phenyl)-6-(2-chloro-5-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(2-chloro-5-methyl-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; [4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-yl]-(1H-indazol-5-yl)-amine; 6-(5-chloro-2-fluoro-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; 6-(2-bromo-5-methyl-phenyl)-N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; 4-[4-Amino-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-benzaldehyde; N-(4-Chloromethyl-phenyl)-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine-2,4-diamine; or physiologically acceptable salts thereof.