Patent ID: 6165996
Filing Date: 2000-12-26
Classification: A61K,A61P,C07D,C07F,Y10S

Abstract:
A method for inhibiting bacterial or fungal growth on a surface or in a solution subject comprising administering to said surface or solution a complexing agent having the formula ##STR215## wherein, t, u, and v are each independently 2 or 3;w is an integer of from 1 to 4;R.sup.12 and R.sup.13 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by one or more oxa, alkenyl interrupted by one or more oxa, alkyl interrupted by thia, alkenyl interrupted by thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, and halogen-substituted versions thereof;R.sup.11 is a member selected from the group consisting of R.sup.12, R.sup.13, and radicals of the formula: ##STR216## wherein, R.sup.41, R.sup.42, and R.sup.43 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by oxa, alkenyl interrupted by oxa, alkyl interrupted by thia, alkenyl interrupted by thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, and halogen-substituted versions thereof;R.sup.44 is a member selected from the group consisting of H, hydroxy, amino, alkyl interrupted by oxa, alkoxy, aryl, aryloxyalkyl, alkoxyaryl, and halogen-substituted versions thereof;n is zero or 1; andX is a member selected from the group consisting of alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by one or more oxa, alkenyl interrupted by one or more oxa, alkyl interrupted by one or more thia, alkenyl interrupted by one or more thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, halogen-substituted versions thereof, and radicals selected form the group consisting of: ##STR217## wherein, R.sup.41, R.sup.42, R.sup.43 and R.sup.44 are each independently as described above;R.sup.46 and R.sup.47 are each independently selected from the group consisting of H, alkyl and aryl, or taken together form a divalent linking group between the atoms to which they are attached, thereby forming a ring structure;R.sup.48 and R.sup.49 are each independently selected from the group consisting of H, alkyl, aryl, alkoxy, alkyl interrupted by oxa, aryloxyalkyl, alkoxyaryl, and halogen-substituted versions thereof;R.sup.50, R.sup.51 and R.sup.52 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenyloxy, allkenylthio, aryloxy, arylthio, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylakyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, and hydroxyarylalkyl; andm is an integer of from 1 to 3,and wherein, optionally, any two R.sup.11 groups are combined to form a ring structure; and dimers thereof, said dimers being formed by the covalent attachment of two complexing agents of formula II through a linking group having from 1 to 6 carbon atoms;and physiological salts thereof; with the proviso that the molecular weight of said complexing agent does not exceed 2000.