Patent ID: 6683052
Filing Date: 2004-01-27
Classification: A61K,A61P,C07K,Y02A

Abstract:
An isolated lipopeptide, comprising:a peptide which binds to an interferon-gamma (IFN-&ggr;) receptor intracellularly, but which does not bind to the IFN-&ggr; receptor extracellularly, said peptide consists of a peptide sequence delimited by amino acids located in positions 95 and 133 or 132 of murine LFN-&ggr;, reference SEQ ID NO:17; and a lipophilic molecule selected from the group consisting of a linear or branched, saturated or unsaturated C4 to C20 hydrocarbon-based chain, and a steroid group, said steroid group optionally linked to said hydrocarbon-based chain, wherein said lipophilic molecule is covalently linked to the peptide and is optionally combined with a short vector peptide comprising a group that is ionized at physiological pH, and a group for covalently bonding to said hydrocarbon-based chain or said steroid group.