Patent ID: 8697741
Filing Date: 2014-04-15
Classification: A61P,C07D

Abstract:
1. A process for the preparation of amorphous atorvastatin calcium which comprises: a) provision of a reaction mixture having a pH between 6.5 and 8.0 containing a sodium salt of atorvastatin and tetrahydrofuran, wherein the reaction mixture is prepared by a process which comprises: b) addition of a non-cyclic chlorinated organic solvent selected from the group consisting of dichloromethane, trichloroethane, tetrachloroethane and chloroform to the reaction mixture to provide a mixture of organic solvents; c) addition of an equivalent or an excess quantity of a source of calcium ions selected from the group consisting of calcium acetate and calcium chloride; and d) isolation of amorphous atorvastatin calcium from an organic phase comprising the mixture of organic solvents, wherein the isolation step comprises an addition of a ether solvent in which atorvastatin calcium is not soluble or is poorly soluble.