Patent ID: 9155753
Filing Date: 2015-10-13
Classification: A61K,A61P

Abstract:
1. A method for inhibiting the proliferation of carcinoma cells that express an EGF receptor, comprising (a) exposing the cells to an anti-EGF receptor antibody trastuzumab, and (b) either preceding, following, or concomitantly with step (a), exposing the cells to a telomerase inhibitor comprising an oligonucleotide which is characterized by: (i) N3′→P5′ thiophosphoramidate internucleoside linkages; (ii) comprising the sequence identified as SEQ ID NO: 12; and (iii) a palmitoyl (C16) moiety linked to the 5′ terminus of the oligonucleotide via a glycerol or aminoglycerol linker wherein the carcinoma cells are breast cancer or non-small cell lung cancer cells.