Patent ID: 6562827
Filing Date: 2003-05-13
Classification: A61P,C07D

Abstract:
A compound of formula I or a tautomeric or isomeric form, an enantiomeric or diastereomeric form, or a physiologically tolerable salt, whereinA is piperazine, homopiperazine, hexahydroazepine, piperidine or pyrrolidine, which can additionally carry a radical R5 and B is a phenyl, pyridine, pyrimidine, pyrazine or pyridazine ring and R1 and R2 independently of one another are hydrogen, C1-C6-alkyl, which is branched or unbranched, Oâ€”C1-C6-alkyl, which is branched or unbranched, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, NHCOâ€”C1-C4-alkyl, NHCO-phenyl, CONHR9, NHSO2â€”C1-C4-alkyl, NHSO2-phenyl, SO2â€”C1-C4-alkyl and SO2-phenyl and R1 and R2 can be a chain â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, which can additionally carry one or two substituents R6, and R3 is C1-C6-alkyl, which is branched or unbranched and which can additionally carry an Sâ€”CH3 radical, cyclohexyl, cyclopentyl, cycloheptyl, phenyl, pyridyl, pyrimidyl, pyridazyl, pyrazinyl, indolyl, thienyl or naphthyl ring, where the rings are substituted by at most two radicals R7 and R7 is hydrogen, C1-C4-alkyl, which is branched or unbranched, Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, CONHR9, NHCOâ€”C1-C4-alkyl, NHCO-phenyl, NHSO2â€”C1-C4-alkyl, NHSO2-phenyl, SO2â€”C1-C4-alkyl and SO2-phenyl, and R4 is hydrogen, â€”COR8, where R8 can be â€”OR9 and â€”NR9R10 and R5 is hydrogen, C1-C6-alkyl, which is branched or unbranched, which can additionally carry a substituent R11, or R5 can be a phenyl, pyridyl, pyrimidyl, pyridazyl, pyrazinyl, pyrazyl, naphtyl, thienyl, piperidinyl, pyrrolidinyl or imidazolyl ring, which can additionally carry one or two substituents R6 and R6 is hydrogen, C1-C6-alkyl, which is branched or unbranched, Oâ€”C1-C6-alkyl, which is branched or unbranched, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl or C1-C4-alkyl-NR9R13 or two radicals R6 can be a bridge OC(R9)2O and R9 is hydrogen, C1-C6-alkyl, which is branched or unbranched, and R10 is hydrogen, C1-C6-alkyl, which is branched or unbranched, which can additionally be substituted by a phenyl ring which can additionally carry a radical R12, and by andR11 can be a phenyl, pyridyl, pyrimidyl, naphtyl, thienyl, furyl, pyridazyl, pyrazinyl, pyrazolyl, pyrrolyl or imidazolyl ring which can additionally carry one or two substituents R6, and R12 is hydrogen, C1-C6-alkyl, which is branched or unbranched, Oâ€”C1-C6-alkyl, which is branched or unbranched, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl and R13 is hydrogen, a C1-C4-alkyl chain and C0-C4-alkylphenyl, where the phenyl ring can additionally carry one or two radicals R12 and x is 0, 1 or 2.