Patent ID: 6147217
Filing Date: 2000-11-14
Classification: A61P,C07C,C07D

Abstract:
A compound of Formula VI ##STR31## wherein R.sup.1 is chosen from the group consisting of ##STR32## wherein D represents the residue of a 5- or 6-membered, saturated or aromatic ring;R.sup.2 is chosen from hydrogen, trialkylsilyl, benzyl, tetrahydropyran-2-yl, lower-alkylcarbonyl, arylcarbonyl and arylmethyl, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo;R.sup.3 is chosen from alkoxy, wherein the alkoxy group contains from one to about 8 carbon atoms; alkenyloxy, wherein the alkenyloxy group contains from one to about 4 carbon atoms; arylmethoxy, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo; and --NR.sup.6 R.sup.7 ;R.sup.4 is chosen from trialkylsilyl, Li.sup.+, benzyl, tetrahydropyran-2-yl, lower-alkylcarbonyl, arylcarbonyl and arylmethyl, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo;R.sup.5 is alkyl of 1 to 6 carbons; andR.sup.6 and R.sup.7 are chosen independently from hydrogen, alkyl of 1 to 8 carbons and benzyl.