Patent ID: 8524279
Filing Date: 2013-09-03
Classification: A61K,A61P,B01D,B01J

Abstract:
1. A method for making a powder pharmaceutical for pulmonary administration, the method comprising: providing a feedstock containing an active agent in a liquid vehicle, wherein the active agent comprises one or more of an antibiotic, an anti-inflammatory agent, and a bronchodilator; providing a multi-nozzle atomizer comprising a housing supporting a central gas nozzle and a plurality of atomization nozzles around the central gas nozzle, wherein each atomization nozzle comprises a liquid nozzle and a gas nozzle that is configured as a cap surrounding the liquid nozzle, and wherein the central gas nozzle is not associated with a liquid nozzle; atomizing the feedstock from the multi-nozzle atomizer to produce a droplet spray, wherein the feedstock is fed through the housing to the liquid nozzles in each of the atomization nozzles; and flowing the droplet spray in a heated gas stream to evaporate the liquid vehicle of the feedstock and produce a powder of dry particulates comprising the active agent, wherein the dry particulates have an average particle size of less than 5 microns.