Patent ID: 6218572
Filing Date: 2001-04-17
Classification: C07C

Abstract:
A process for preparing N-protected N-alkylated amino acids of the formula I: ##STR5##whereR.sup.s is an unsubstituted or substituted carbobenzoxy radical,R.sup.1 is the side chain of a proteinogenous amino acid or derivative thereof,R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, aryl or hetaryl andR.sup.3 is C.sub.1-2 -alkyl which comprises mixing a compound of the formula II: ##STR6##where R.sup.1, R.sup.2 and R.sup.s have the abovementioned meanings, with a solution of the base potassium tert-butanolate or the base sodium tert-butanolate in a non-protic organic solvent and subsequently adding a C.sub.1-2 -alkyl halide alkylating agent wherein from 2.2 to 10 equivalents of the base is used, based on II.