Patent ID: 6403568
Filing Date: 2002-06-11
Classification: A61P,C07H

Abstract:
A 4â€²-C-ethynyl pyrimidine represented by the following formula (1): wherein B represents a pyrimidin-1-yl or a derivative thereof, wherein the derivative is a pyrimidin-1-yl having a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an alkenyl group, a haloalkyl group, an alkynyl group, an amino group, an alkylamino group, a hydroxy group, a hydroxyamino group, an aminoxy group, an alkoxy group, a mercapto group, an alkylmercapto group, an aryl group, an aryloxy group, and a cyano group, and R represents a hydrogen atom or a phosphate ester group, and X represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, provided that the compound is not 4â€²-C-ethynylthymidine, 4-â€²-C-ethynyl-2-â€²-deoxycytidine, 4â€²-C-ethynyl-2â€²-deoxy-5fluorocytidine, or 1-(4â€²-C-ethynyl-&bgr;-D-arabinopentofuranosyl)cytosine.