Patent ID: 6281239
Filing Date: 2001-08-28
Classification: A61K,A61P,A61Q

Abstract:
A topical antifungal composition for treating onychomycosis consisting essentially of up to 5 wt.% of an antifungal agent in admixture with a tissue softening composition, wherein the tissue softening composition comprises:(a) about 40 wt-% urea;(b) about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;(c) about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;(d) about 0.25 to about 2 wt-% of a C.sub.16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;(e) about 1 to about 5 wt-% propylene glycol;(f) about 1 to about 3 wt-% glyceryl stearate;(g) about 0.01 to about 0.5 wt-% xanthan gum; and(h) the balance being water.