Patent ID: 8692018
Filing Date: 2014-04-08
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
1. A preparation method of chiral carboxylic acids, being that the asymmetric catalytic hydrogenation of tri-substituted α,β-unsaturated carboxylic acids is carried out with the presence of a chiral iridium complex of a chiral phosphor nitrogen ligand and an alkaline additive to obtain chiral carboxylic acids having optical purity, wherein it is carried out by the following catalytic hydrogenation reaction process: wherein: [Ir] is the iridium complex catalyst of the chiral phosphor nitrogen ligand; R wherein the iridium complex catalyst of the chiral phosphor nitrogen ligand has the following structural formula: wherein: is the chiral phosphor nitrogen ligand; is cyclooctadiene; X is halogen, C 1 -C 8 carboxylate radical, sulfate radical, tetra (3,5-bis trifluoromethylphenyl) borate radical, tetra (pentafluorophenyl) borate radical, tetra (perfluoro-tert-butoxy) aluminum ion, tetra (hexafluoroisopropoxy) aluminum ion, hexafluoro phosphate ion, hexafluoro antimonlate ion, tetrafluoro borate ion or triflluoro methanesulfonate ion; cyclooctadiene ligand can be substituted by ethylene or norbornadiene wherein the chiral phosphor nitrogen ligand contained in the iridium complex catalyst of the chiral phosphor nitrogen ligand has the following structural formula: wherein: m=0-3, each of R R R the C the C