Patent ID: 9080214
Filing Date: 2015-07-14
Classification: C12Q

Abstract:
1. A method of treating a human patient for one or more psychotic symptoms of using iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt of iloperidone or an iloperidone metabolite, the method comprising: determining, from a biological sample of the individual, the individual's genotype at the SNP_A-2048427 single nucleotide polymorphism (SNP) locus; determining, from a biological sample of the individual, the individual's genotype at the SNP_A-2274533 SNP; determining, from a biological sample of the individual, the individual's genotype at the SNP_A-2283283 SNP; in the case that the individual's genotype is determined to be non-GG at the SNP-A-2048427 SNP, AA at the SNP_A-2274533 SNP, and non-GG at the SNP-A-2283283 SNP, predicting that treating the individual with a daily dosage of 24 mg of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt of iloperidone or an iloperidone metabolite will be efficacious and administering to the individual a daily dosage of 24 mg of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt of iloperidone or an iloperidone metabolite; and in the case that the individual's genotype is determined to be GG at the SNP-A-2048427 SNP, non-AA at the SNP_A-2274533 SNP, or GG at the SNP-A-2283283 SNP, predicting that treating the individual with the daily dosage of 24 mg of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt of iloperidone or an iloperidone metabolite will be less efficacious than treating the individual with a daily dosage greater than 24 mg and administering to the individual a daily dosage greater than 24 mg of iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt of iloperidone or an iloperidone metabolite.