Patent ID: 6127358
Filing Date: 2000-10-03
Classification: C12P

Abstract:
A process for preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof comprising the steps of:removing solids from a clavulanic acid containing fermentation broth by microfiltration to form a first filtrate,further removing solids from the first filtrate by ultrafiltration to form a second filtrate,concentrating the second filtrate by removal of water, andtreating the concentrated second filtrate to isolate clavulanic acid or a pharmaceutically acceptable salt or ester thereofcharacterised in that the first filtrate is filtered using an ultrafiltration membrane having a molecular weight cut-off of 10 to 30 kD and a permeate flow rate of 10 to 30 lm.sup.-2 h.sup.-1.