Patent ID: 6489349
Filing Date: 2002-12-03
Classification: A61K,A61P,C07D,Y02A

Abstract:
A pharmaceutical composition for inhibiting cytokine production and/or secretion, the pharmaceutical composition incorporating a compound having the formula: where X is nitrogen or carbon bonded to a substituent species, wherein the substituent species are selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, F, Cl, Br, I, NRâ€²Râ€³, CF3, OH, CN, NO2, C2Râ€², SH, SCH3, N3, SO2CH3, ORâ€², (CRâ€²Râ€³)qORâ€², Oâ€”(CRâ€²Râ€³)qC2Râ€², SRâ€², C(&boxH;O)NRâ€²Râ€³, NRâ€²C(&boxH;O)Râ€³, C(&boxH;O)Râ€², (CRâ€²Râ€³)qC2Râ€², C(&boxH;O)ORâ€², OC(&boxH;O)Râ€², OC(&boxH;O)NRâ€²Râ€³ and NRâ€²C(&boxH;O)ORâ€², where q is an integer from 1 to 6 and Râ€² and Râ€³ are individually hydrogen, alkyl, cycloalkyl, non-aromatic heterocyclic ring or an aromatic group-containing species; A, Aâ€² and Aâ€³ are selected from the substituent species defined for X; Bâ€² is selected from: wherein Xâ€² is nitrogen; m is an integer and n is an integer such that the sum of m plus n is 1, 2, 3, 4, 5, 6, 7, or 8; EI, EII, EIII, EIV, EV and EVI individually represent hydrogen, lower alkyl or halo substituted lower alkyl, such that at least one of EI, EII, EIII, EIV, EV and EVI is not hydrogen; Zâ€² and Z individually are hydrogen or lower alkyl; and the wavy-line in the structure indicates that the compound can have a cis (Z) or trans (E) form.