Patent ID: 6265407
Filing Date: 2001-07-24
Classification: A61P,C07D

Abstract:
A compound of formula (I), ##STR16##the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, whereinR.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, C.sub.1-6 alkylthio, amino, mono- or di(C.sub.1-6 alkyl)amino, Ar.sup.1, Ar.sup.1 --NH--, C.sub.3-6 cycloalkyl, hydroxymethyl or benzyloxymethyl;R.sup.2 and R.sup.3 are hydrogen, or taken together may form a bivalent radical of formula --CH.dbd.CH--CH.dbd.CH--;R.sup.4, R.sup.5 and R.sup.6 are each independently selected from hydrogen, halo, C.sub.1-6 akyl, C.sub.1-6 alkyloxy, trifluoromethyl, nitro, amino, cyano, azido, C.sub.1-6 alkyloxyC.sub.1-6 alkyl, C.sub.1-6 alkylthio, C.sub.1-6 alkyloxycarbonyl or Het.sup.1 ;or when R.sup.4 and R.sup.5 are adjacent to each other they may be taken together to form a radical of formula --CH.dbd.CH--CH.dbd.CH--; ##STR17##wherein X is a direct bond, --O--, --S--, C.dbd.O, --NR.sup.8 -- or Het.sup.2 ;R.sup.7 is hydrogen, C.sub.1-6 alkyl or Ar.sup.2 methyl;R.sup.8 is hydrogen, C.sub.1-6 alkyl or Ar.sup.2 methyl;Alk.sup.1 is C.sub.1-6 alkanediyl;Alk.sup.2 is C.sub.1-4 alkanediyl;Ar.sup.1 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, trihalomethyl, amino or nitro;Ar.sup.2 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, trihalomethyl, amino or nitro;Het.sup.1 is a monocyclic heterocycle selected from oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl or oxazolinyl; and each monocyclic heterocycle may optionally be substituted on a carbon atom with C.sub.1-4 alkyl; andHet.sup.2 is tetrahydrofuran; a tetrahydrofuran substituted with C.sub.1-6 alkyl; a dioxane; a dioxane substituted with C.sub.1-6 alkyl; a dioxolane; or a dioxolane substituted with C.sub.1-6 alkyl.