Patent ID: 9116122
Filing Date: 2015-08-25
Classification: G01N

Abstract:
1. An optical biosensor for detecting a bio-molecular sample, said biosensor comprising: a laser source that emits a photon beam in an axial direction into an ambient medium; a collimating lens disposed along an incidence plane and normal to said axial direction to concentrate said beam; a pre-selection polarizer disposed normal to said beam to polarize said beam by pre-selection angle α about said axial direction thereby yielding a |ψ an optical right-isosceles prism having a dielectric constant greater than said ambient medium, said prism including incident and exodus sides perpendicular to each other and an opposite diagonal side, said beam entering said prism through said incident side, reflecting by said diagonal side and exiting towards said vertical direction through said exodus side; a metal film disposed on said diagonal side to provide surface plasmon resonance (SPR) amplification of a Goos-Hänchen (GH) effect; a liquid medium containing the sample, said medium being disposed along said metal film opposite said diagonal side; a post-selection polarizer disposed normal to said lateral direction to polarize said beam by post-selection angle β about said lateral direction thereby yielding a |ψ a photon detector for detecting said beam to obtain weak value of a polarization difference operator =|s s|−|p p|, thereby enabling Aharonov-Albert-Vaidman (AAV) amplification; and a pointer estimator for measuring a sample mean intensity, to determine a GH shift Δ