Patent ID: 8252303
Filing Date: 2012-08-28
Classification: A61K,A61P

Abstract:
1. An injectable depot composition comprising: (a) a bioerodible, biocompatible polymer; (b) a solvent selected from the group consisting of aromatic alcohols, esters of aromatic acids, aromatic ketones, and mixtures thereof, said solvent having a miscibility in water of less than or equal to 7% at 25° C., and present in an amount effective to plasticize the polymer and form a gel therewith; (c) a thixotropic amount of a thixotropic agent mixed with the polymer effective to form a thixotropic composition, the thixotropic agent comprising a lower alkanol and said amount being between 0.01 weight percent and 15 weight percent of the combined weight of the solvent and the thixotropic agent; and (d) a beneficial agent; wherein the injectable depot composition does not comprise an emulsion.