Patent ID: 7410757
Filing Date: 2008-08-12
Classification: A61K,A61P,C07K

Abstract:
1. A method of screening for a candidate of a suppressor gene of Alzheimer's Disease, wherein said method comprises the steps of: (a) expressing in a population of cells a library of nucleic acids obtained from or synthesized from nucleic acids expressed in a tissue of a brain of an organism suffering from Alzheimer's Disease, wherein said tissue is obtained from an area of the brain showing cell death as a pathological feature of Alzheimer's Disease, and wherein said tissue comprises surviving or normal cells; (b) detecting a suppressive effect on Alzheimer's Disease due to the expression of a nucleic acid of the library, wherein the suppressive effect is a suppression of cell death; and, (c) selecting the nucleic acid having the suppressive effect; thereby identifying a candidate of a suppressor gene of Alzheimer's Disease.