Patent ID: 7807351
Filing Date: 2010-10-05
Classification: C12Q,G01N

Abstract:
1. An aptamer-probe complex for detecting the presence of a target molecule, said complex comprising: an aptamer moiety which is able to bind to thrombin and inhibit the enzyme activity of thrombin; and a probe moiety which is able to bind to the target molecule, wherein the target molecule is a nucleic acid, and the probe moiety of the aptamer-probe complex is an oligonucleotide capable of hybridizing with the nucleic acid and is located on the 3′ side of the aptamer moiety, and wherein when the probe moiety does not bind to the target molecule, said aptamer moiety does not bind to thrombin and thrombin exhibits its activity, and when the probe moiety binds to the target molecule, said aptamer moiety binds to the thrombin and inhibits the enzyme activity of thrombin.