Patent ID: 8318070
Filing Date: 2012-11-27
Classification: A61F,A61K,A61P

Abstract:
1. A method for making an ocular bioerodible implant for treating a medical condition of the eye, the method comprising: a) milling a hydrophilic ended poly(D,L-lactide-co-glycolide) (PLGA) polymer; b) milling a hydrophobic ended poly(D,L-lactide-co-glycolide) (PLGA) polymer; c) blending the milled polymers together with particles of dexamethasone to form a blended mixture comprising a hydrophilic ended PLGA, a hydrophobic ended PLGA, and dexamethasone, wherein at least about 75% of the particles of the dexamethasone have a diameter of less than about 20 μm; d) performing a plurality of heat extrusions of the blended mixture, thereby forming a filament including a homogenous distribution of the dexamethasone, wherein the ocular bioerodible implant has a reduced in-batch variability relative to a single extrusion implant.