Patent ID: 6784309
Filing Date: 2004-08-31
Classification: C07K

Abstract:
A process for purifying N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of:(a) washing N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester with water; (b) recovering by filtration the water washed N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester in solid form; (c) combining the recovered N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester with an organic solvent to form a slurry; (d) recovering by filtration N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester from the slurry in solid form; and (e) washing said recovered N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester with water and organic solvent.