Patent ID: 6737425
Filing Date: 2004-05-18
Classification: A61P,C07D

Abstract:
An N,N-substituted cyclic amine compound represented by the following formula (VIII): whereinA represents an aryl group which may be substituted, a heteroaryl group which may be substituted, an aralkyl group which may be substituted, or a heteroaryl alkyl group which may be substituted; E represents a group represented by the formula â€”COâ€” or a group represented by the formula â€”CHOHâ€”; G represents an oxygen atom, a sulfur atom, and a group represented by the formula â€”NR10â€”, wherein R10 represents a hydrogen atom, a lower alkyl group, a lower cycloalkyl, a lower acyl group or a lower alkyl sulfonyl group, a group represented by â€”COâ€”, a group represented by â€”COOâ€”, a group represented by the formula â€”CONR11, wherein R11 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”NR12COâ€”, _wherein R12 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”SOâ€”, a group represented by the formula â€”SO2â€”, a group represented by the formula â€”SONR13â€”, wherein R13 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”NR14SOâ€”, wherein R14 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”SO2NR15â€” wherein R15 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”NR16SO2â€”, wherein R16 represents a hydrogen atom or a lower alkyl group, a group represented by the formula >C&boxH;Nâ€”OR17, wherein R17 represents a hydrogen atom or a lower alkyl group, a group represented by the formula â€”NHCONHâ€”, a group represented by the formula â€”NHCSNHâ€”, a group represented by the formula â€”C(&boxH;NH)NH, a group represented by the formula â€”NHC(&boxH;NH)â€”, a group represented by the formula â€”OCOSâ€”, a group represented by the formula â€”SCOOâ€”, a group represented by the formula â€”OCOOâ€”, a group represented by the formula â€”NHCOOâ€”, a group represented by the formula â€”OCONHâ€”, a group represented by the formula â€”CO(CH2)sOâ€”, a group represented by the formula â€”CHOHâ€” or a group represented by the formula â€”CHOH(CH2)sOâ€”, wherein s represents 0 or an integer of 1 to 6; J represents an aryl group which may be substituted or a heteroaryl group which may be substituted; R1 represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower cycloalkyl group, a hydroxy lower alkyl group, a lower alkoxyalkyl group, a cyano-lower alkyl group, a halogenated lower alkyl group, an optionally N-substituted amino-lower alkyl group, a group represented by the formula â€”NR18R19, wherein R18 and R19 may be the same as or different from each other and each represents a hydrogen atom or a lower alkyl group, an aralkyl group, a morpholinyl group, a thiomorpholinyl group, a piperidyl group, a pyrrolidinyl group or a piperazinyl group; Alk represents a linear or branched lower alkylene group; and n, v, x, w and y are independent of each other and each represents 0 or 1, and p represents 2 or 3, provided that x is 1 when G is â€”COâ€”, or a pharmacologically acceptable salt thereof.