Patent ID: 6048548
Filing Date: 2000-04-11
Classification: A61K,C08J

Abstract:
A method of preparing a bioavailable sustained release oral dosage form comprisingcombining (i) a medicament in amorphous form, (ii) a wetting agent and (iii) a sustained release excipient to obtain a mixture; said sustained release excipient comprising a gelling agent, an ionizable gel enhancing agent, and an inert diluent, the ratio of inert diluent to gelling agent being from about 1:8 to about 8:1; said ionizable gel strength enhancing agent increasing the gel strength of a gel formed when said solid dosage form is exposed to an aqueous solution and said gelling agent comprising xanthan gum and locust bean gum in a ratio of said xanthan gum to said locust bean gum of from about 1:3 to about 3:1;thereafter drying and milling said mixture to obtain a sustained release product; andthen forming said sustained release product into orally administrable unit doses.