Patent ID: 6313129
Filing Date: 2001-11-06
Classification: A61K,A61P,C07D

Abstract:
A therapeutic method for treating organ transplant rejection in a mammal comprising administering to a mammal an effective amount of a compound of formula I: ##STR5##whereinX is selected from the group consisting of HN, R.sub.11 N, S, O, CH.sub.2, and R.sub.11 CH;R.sub.11 is (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkanoyl;R.sub.1 -R.sub.5 are each independently selected from the group consisting of hydrogen, hydroxy and halo;R.sub.6, R.sub.7, and R.sub.8 are each independently selected from the group consisting of hydrogen, hydroxy, mercapto, amino, nitro, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio and halo; andR.sub.6 and R.sub.10 are each independently hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, halo or (C.sub.1 -C.sub.4)alkanoyl; or R.sub.9 and R.sub.10 together are methylenedioxy; or a pharmaceutically acceptable salt thereof.