Patent ID: 8076492
Filing Date: 2011-12-13
Classification: C07D

Abstract:
1. A process for the preparation of trityl olmesartan medoxomil of formula (VI): comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester of formula (II): wherein R is C in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula (V), (b) deesterifying the compound of formula (V) with a base; and (c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV), wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula (VI), wherein the products of steps (a) and (b) are not isolated and steps (a), (b) and (c) are carried out in a single reaction vessel.