Patent ID: 6774235
Filing Date: 2004-08-10
Classification: A61P,C07D

Abstract:
A compound of formula (II) wherein R4â€² is cyano;R3 is hydrogen, Aâ€² is CH, W1 is a halogen, and L is â€”Xâ€”R5 or â€”Xâ€”Alkâ€”R6; wherein R5 and R6 each independently are indanyl, indolyl or phenyl; each of said indanyl, indolyl or phenyl may be substituted with one, two, three, four or five substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, hydroxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, formyl, cyano, nitro, amino and trifluoromethyl; Alk is C1-4 alkanediyl; and X is â€”NR3â€”, â€”NHâ€”NHâ€”, â€”N&boxH;Nâ€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€” or â€”S(&boxH;O)2â€”; provided that R5 is other than p-cyano-phenyl, p-nitro-phenyl, p-methoxy-phenyl and p-aminocarbonyl-phenyl, and â€”Xâ€”Alkâ€”R6 is other that 2-(4-hydroxyphenyl)ethylamino.