Patent ID: 9044319
Filing Date: 2015-06-02
Classification: A61F

Abstract:
1. An anchored cardiovascular valve, comprising: an expandable valve support member comprising remodelable acellular extracellular matrix (ECM) from a first mammalian tissue source, said ECM valve support member being capable of transitioning from a support member pre-deployment configuration, wherein said support member is capable of being positioned within a cardiovascular structure, to a support member post-deployment configuration, wherein said support member is disposed proximate host cardiovascular tissue of said cardiovascular structure, and wherein bioremodeling of said ECM valve support member and said host cardiovascular tissue, and regeneration of new cardiovascular tissue and cardiovascular tissue structures with site-specific structural and functional properties are induced, said ECM valve support member having a longitudinal axis, an outer surface, a lumen, an inlet portion and an outlet portion, said lumen defining a support member inner surface, said outlet portion defining an outlet in communication with said lumen, said outlet portion being outwardly reflected over and attached to said valve support member outer surface, wherein a first anchor pocket is formed therein, said inlet portion defining an inlet in communication with said lumen, said inlet portion being inwardly reflected within said ECM valve support member lumen and attached to said support member inner surface at a first attachment point, wherein a second anchor pocket is formed therein, and wherein a first valve leaflet is formed within said ECM valve support member lumen, said valve leaflet being sized and configured to selectively restrict fluid flow through said support member; and first and second biodegradable expandable anchoring mechanisms, said first biodegradable expandable anchoring mechanism being disposed in said first anchor pocket, said second biodegradable expandable anchoring mechanism being disposed in said second anchor pocket, said first and second biodegradable anchoring mechanisms being capable of transitioning from an anchoring mechanism pre-deployment configuration, wherein said ECM valve support member is configured in said support member pre-deployment configuration, to an anchoring mechanism post-deployment configuration, wherein said first and second biodegradable expandable anchoring mechanisms temporarily position said ECM valve support member proximate said host cardiovascular tissue of said cardiovascular structure and maintain contact therewith for an anchor support period of time within said process of new cardiovascular tissue regeneration, wherein bioremodeling of said ECM valve support member and host cardiovascular tissue, and regeneration of cardiovascular tissue structures with site-specific structural and functional properties are induced, and wherein said first and second biodegradable expandable anchoring mechanisms degrade during said anchor support period of time.