Patent ID: 7301022
Filing Date: 2007-11-27
Classification: A61P,C07D

Abstract:
1. A compound having the structure:  or any pharmaceutically-acceptable salt thereof, wherein: J is O or S; X is N or C(R Y is N or C(R n is independently, at each instance, 0, 1 or 2; R or R 1 is R b substituted by 1, 2 or 3 substituents selected from R e , R h , —OR e , —OR h , —OC 2-6 alkylNR a R e , —OC 2-6 alkylOR e , —NR a R e , —NR a R h , —NR a C 2-6 alkylNR a R e , —NR a C 2-6 alkylOR e , —CO 2 R e , —OC(═O)R e , —C(═O)R e , —C(═O)NR a R e , —C(═O)NR a R h , —NR a C(═O)R e , —NR a C(═O)R h , —NR a C(═O)NR a R e , —NR a CO 2 R e , —C 1-8 alkylOR e , —C 1-6 alkylNR a R e , —S(═O) n R e , —S(═O) 2 NR a R e , —NR a S(═O) 2 R e , —OS(═O) 2 R e , —OC(═O)NR a R e , —OC 2-6 alkylNR a R h , —OC 2-6 alkylOR h , —NR a C 2-6 alkylNR a R h , —NR h C 2-6 alkylNR a R a , —NR h C 2-6 alkylOR a , —NR a C 2-6 alkylOR h , —CO 2 R h , —OC(═O)R h , —C(═O)R h , —NR e C(═O)R a , —NR h C(═O)R a , —NR h C(═O)NR a R a , —NR e C(═O)NR a R a , —NR h CO 2 R a , —NR e CO 2 R a , —C 1-8 alkylOR h , —C 1-6 alkylNR a R h , —S(═O) n R h , —S(═O) 2 NR a R h , —NR a S(═O) 2 R h , —NR h S(═O) 2 R a , —OS(═O) 2 R h and OC(═O)NR a R h , and additionally substitued by 0, 1, 2 or 3 substituents independently selected from halo, cyano, nitro, C 1-8 alkyl, C 1-4 haloalkyl, R i , R k , —OR a , —NR a R a , —OC 2-6 alkylNR a R a , —OC 2-6 alkylOR a , —NR a C 2-6 alkylNR a R a , —NR a C 2-6 alkylOR a , —CO 2 R a , —OC(═O)R a , —C(═O)(C 1-6 alkyl), —C(═O)NR a R a , —NR a C(═O)R a , —NR a C(═O)NR a R a , —NR a CO 2 R a , —C 1-8 alkylOR a , —C 1-6 alkylNR a R a , —S(═O) n R a , —S(═O) 2 NR a R a , —NR a S(═O) 2 R a , —OS(═O) 2 R a and —OC(═O)NR a R e ; R R R R R R R A) B)