Patent ID: 6090852
Filing Date: 2000-07-18
Classification: A61P,C07C,Y10S

Abstract:
A compound of formula (I): ##STR25## and a pharmaceutically- and/or veterinarily-acceptable salt thereof, and a solvate of such compound and salt,whereinR.sup.1 and R.sup.2 are each independently H,C.sub.2-6 alkenyl, aryl(C.sub.1-6 alkyl), heteroaryl(C.sub.1-6 alkyl), aryloxy(C,.sub.4 alkyl), heteroaryloxy-(C.sub.1-6 alkyl),C.sub.1-6 alkyl optionally substituted by NH.sub.2, C.sub.2-6 acylamino, OH, or by CO.sub.2 H,or R.sup.1 and R.sup.2 can be taken together with the carbon atom to which they are attached, to form a 4- to 8-membered saturated carbocyclic or heterocyclic ring, which heterocyclic ring has 1 or 2 hetero-groups selected from O, S(O).sub.n or NR.sup.9 in the ring,R.sup.3 is H, C.sub.1-6 alkyl or (C.sub.1-6 alkoxy)C.sub.1-6 alkyl,R.sup.4, R.sup.5, R.sup.7 and R.sup.8 are each independently H, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CN or halogen,R.sup.6 is H, aryl, heteroaryl, aryloxy or heteroaryloxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CN or halogen,R.sup.9 is H or C.sub.1-6 alkyl,n is 0, 1 or 2,X is C.sub.1-6 alkylene or C.sub.2-6 alkenylene,Y is a direct link, CH=CH or O,wherein ""aryl"" is phenyl optionally fused with another ring selected from furan, dioxolan, and pyran,which group is optionally mono- or disubstituted by substituents independently seleceted from halogen, CN, C.sub.1-6 alkyl optionally substituted by OH or NH.sub.2, C.sub.1-6 alkoxy, perfluoro(C.sub.1-6 alkyl) and perfluoro(C.sub.1-6 alkoxy),and wherein ""heteroaryl"" is a 5- or 6-membered aromatic heterocycle with one or two heteroatoms in the ring, which heteroatoms are independently selected from O, N and S, which heteroaryl is optionally mono- or disubstituted by substituents independently selected from halogen, CN, C.sub.1-6 alkyl optionally substituted by OH or NH.sub.2, C.sub.1-6 alkoxy, perfluoro(C.sub.1-6 alkyl) and perfluoro(C.sub.1-6 alkoxy).