Patent ID: 6090834
Filing Date: 2000-07-18
Classification: C07D,C07F

Abstract:
A compound of Formula I ##STR89## wherein R is selected from hydrido, mercapto, hydroxyl, carboxymethylthio, carboxyethylthio, trifluoromethoxy, methylthio, ethylthio, methylsulfinyl, methylsulfonyl, methoxy, ethoxy, propoxy, butoxy, phenyloxy, benzyloxy, N-methylamino, N,N-dimethylamino, N,N-diethylamino, aminocarbonyl, methoxymethyl, a-bromo-carboxymethyl, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, hydroxymethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, ethenyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl, 3-butenyl, hydroxyethenyl, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, hydroxyethynyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cycloheptylmethyl, phenyl and naphthyl, optionally substituted at a substitutable position by fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, pyridyl, thienyl, thiazolyl, oxazolyl, imidazolyl, furyl and quinolyl, optionally substituted at a substitutable position by fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, benzyl, phenethyl, diphenylmethyl and phenylpropyl, optionally substituted at a substitutable position on the phenyl radical by fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, phenoxymethyl optionally substituted at a substitutable position on the phenyl radical with fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, benzyloxymethyl optionally substituted at a substitutable position on the phenyl radical with fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, pyridyloxymethyl and quinolyloxymethyl optionally substituted at a substitutable position with fluoro, chloro, bromo, iodo, carboxy, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy and butoxy, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl, methoxycarbonylmethyl, ethoxycarbonylmethyl, methoxycarbonylethyl, ethoxycarbonylethyl, carboxy, acetyl, propanoic, butanoic, pentanoic, hexanoic, phenylthiomethyl, aminocarbonylmethyl, N-methylaminocarbonylmethyl and N,N-dimethylaminocarbonylmethyl; wherein R.sup.1 is selected from cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, cyclopentenyl, cycloheptenyl, phenyl, naphthyl, pyridyl, thienyl, thiazolyl, oxazolyl, imidazolyl, furyl, quinolyl, benzothiazolyl, 2,3-thianaphthalenyl, 2,3-dihydrothianaphthalenyl, 2,3-benzofuryl, and 2,3-dihydrobenzofuryl, wherein R.sup.1 is optionally substituted at a substitutable position by methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, amino, methoxy, ethoxy, propoxy, butoxy, N-methylamino, N,N-dimethylamino, fluoro, chloro, bromo and iodo; wherein R.sup.2 is selected from methyl, and amino; wherein R.sup.3 represents one or two radicals selected from fluoro, methoxy and methyl; or a pharmaceutically-acceptable salt thereof.