Patent ID: 6358928
Filing Date: 2002-03-19
Classification: A61K,C07D

Abstract:
An &agr;-amino acid or peptidyl compound having a C-terminal imidazolesulfonylmethylene group, which is a serine protease inhibitor compound of the formula: wherein Y is a group capable of interacting with the substrate recognition site of a serine protease, R1 is hydrogen or branched or unbranched, substituted or unsubstituted C1-C12 alkyl, aryl, alkaryl, aralkyl or acyl substituent, wherein said substituted substituent is substituted with one or more functional moieties selected from the group consisting of: hydroxy, amino, nitro, nitrile, guanidino, sulfinyl, sulfonyl, thiol, and halo, and R2 is branched or unbranched C1-C6 alkyl.