Patent ID: 8658637
Filing Date: 2014-02-25
Classification: A61P,C07D

Abstract:
1. A compound selected from: (3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-b]pyridin-1-yl)acetonitrile; 2,2,2-Trifluoro-1-(1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol; 1-(4-Chloro-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,2,2-trifluoro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol; 2-(7-Chloro-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-c]pyridin-1-yl)acetamide; N-[2-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-b]pyridin-1-yl)acetyl]methanesulfonamide; 1-(7-Chloro-1H-pyrrolo[2,3-c]pyridin-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(7-oxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol; 2,2,2-Trifluoro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-p-tolyl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(1H-pyrrolo[3,2-b]pyridin-3-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethanol; 3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-b]pyridine-1-sulfonic acid dimethylamide; 2-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-b]pyridin-1-yl)acetamide; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(1H-indazol-3-yl)ethanol; Phenyl-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; (1H-Indol-5-yl)-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; (1H-Indol-6-yl)-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; (1H-Indol-7-yl)-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; (1H-Indol-4-yl)-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; [1-(4-Fluorophenyl)-1H-indazol-5-yl]-(2,2,2-trifluoro-1-phenylethyl)amine; (1-Benzyl-2,2,2-trifluoroethyl)-[1-(4-fluorophenyl)-1H-indazol-5-yl]amine; Benzyl-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; (2-Nitrophenyl)-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}amine; N-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}benzene-1,2-diamine; 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}benzenesulfonamide; 2-(7-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethylamino}indol-1-yl)acetamide; 3-Methyl-N 2-{3-[2,2,2-Trifluoro-1-hydroxy-1-(1-methoxymethyl-1H-indazol-5-yl)ethyl]indol-1-yl}acetamide; 2-{3-[2,2,2-Trifluoro-1-hydroxy-1-(1H-indazol-5-yl)ethyl]indol-1-yl}acetamide; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-pyridin-4-yl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-pyrimidin-5-yl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-thiophen-3-yl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol; 2-{3-[2,2,2-Trifluoro-1-hydroxy-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethyl]indol-1-yl}acetamide; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-[1-(6-methylpyridin-3-yl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-[1-(5-methylthiophen-2-yl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(1-methyl-1H-imidazol-4-yl)-1H-indazol-5-yl]-1-(1-methyl-1H-indol-3-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-pyridin-2-yl-1H-indazol-5-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-[1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(6-fluoropyridin-3-yl)-1H-indazol-5-yl]-1-(1-methyl-1H-indol-3-yl)ethanol; (R)-1-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propan-2-ol; (S)-1-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propan-2-ol; 1-(5-Chloro-1,1-dioxo-1H-1λ 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(5-methylthiophen-2-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(tetrahydrofuran-2-ylmethyl)-1H-indol-3-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]ethanol; (3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)acetic acid; 1-(1-Allyl-5-hydroxymethyl-1H-pyrrol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-(5-1,3-Dioxolan-2-ylthiophen-2-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; (3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)acetic acid ethyl ester; 1-(5-Chlorothiophen-2-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-{1-[3-(4-hydroxymethylpiperidin-1-yl)propyl]-1H-indol-3-yl}ethanol; 1-{1-[3-((S)-3-Dimethylaminopyrrolidin-1-yl)propyl]-1H-indol-3-yl}-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-{1-[3-((R)-3-Dimethylaminopyrrolidin-1-yl)propyl]-1H-indol-3-yl}-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(3-pyrrolidin-1-ylpropyl)-1H-indol-3-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-{1-[3-(4-methylpiperazin-1-yl)propyl]-1H-indol-3-yl}ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(3-methylaminopropyl)-1H-indol-3-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(3-morpholin-4-ylpropyl)-1H-indol-3-yl]ethanol; 1-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 3-(6-(2H-Pyrazol-3-yl)-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol; 1-[1-Allyl-6-(2H-pyrazol-3-yl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-(6-Bromo-1-but-3-enyl-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-(1-Benzenesulfonyl-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(propane-2-sulfonyl)-1H-indol-3-yl]ethanol; 3-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propionamide; N-Methyl-3-(3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propionamide; 3-(6-Pyrrolidin-1-yl-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol; 2-(6-Bromo-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)-N-methylacetamide; 4-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)-butane-1,2-diol; 1-(1-But-3-enyl-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-(1-Allyl-6-pyrrolidin-1-yl-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 1-(1-Allyl-6-bromo-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 3-(6-Bromo-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(4-methoxybenzyl)-6-vinyl-1H-indol-3-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-[1-(4-methoxybenzyl)-6-pyrrolidin-1-yl-1H-indol-3-yl]ethanol; 1-[4-Chloro-5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 3-(4-Chloro-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[3,2-d]pyrimidin-5-yl)propane-1,2-diol; 5-Allyl-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 5-Allyl-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 7-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 1-(4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2-(3-Methyl-4-oxo-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,4-dihydropyrrolo[3,2-d]pyrimidin-5-yl)acetamide; 5-(2,3-Dihydroxypropyl)-3-methyl-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 5-Allyl-3-methyl-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 1-Methylcarbamoylmethyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid dimethylamide; 1-(2,3-Dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid dimethylamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid methylamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid carbamoylmethylamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid cyanomethylamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid amide; 2-(2-Cyano-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrol-1-yl)acetamide; 2-(2-Cyano-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrol-1-yl)-N-methylacetamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid dimethylamide; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid; 1-(2,3-Dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid ethyl ester; 3-Hydroxymethyl-7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,4-dihydropyrrolo[2,1-c][1,4]oxazin-1-one; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid ethyl ester; 4-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carbonitrile; 1-(2,3-Dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carbonitrile; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carbonitrile; (1-(2,3-Dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrol-2-yl)morpholin-4-ylmethanone; (1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrol-2-yl)-morpholin-4-ylmethanone; 2-(6-Methyl-7-oxo-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-6,7-dihydropyrrolo[2,3-c]pyridin-1-yl)acetamide; 3-(7-Methoxy-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}pyrrolo[2,3-c]pyridin-1-yl)propane-1,2-diol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(7-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethanol; 4-Bromo-1-(2,3-dihydroxypropyl)-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrazole-3-carbonitrile; 1-Allyl-6-methyl-3-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1,6-dihydropyrrolo[2,3-c]pyridin-7-one; 4-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrazole-3-carbonitrile; 1-(2,3-Dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrazole-3-carbonitrile; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-hydroxymethylthiazol-5-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-hydroxymethylthiazol-4-yl)ethanol; 1-Allyl-4-bromo-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrazole-3-carbonitrile; 1-Allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrazole-3-c arbonitrile; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-morpholin-4-yl-thiazol-4-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-thiazol-5-ylethanol; N-(5-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}thiazol-2-yl)acetamide; 1-(2-Aminothiazol-5-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-morpholin-4-ylthiazol-5-yl)ethanol; 3-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol; 1-[1-(2,2-Dimethyl-1,3-dioxolan-4-ylmethyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]-1-(1-methyl-1H-indol-3-yl)ethanol; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-2-methyl-1H-benzimidazol-5-yl]-1-(1-methyl-1H-indol-3-yl)ethanol; 1-(4-Fluorophenyl)-3-methyl-5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]-1,3-dihydrobenzimidazol-2-one; (3-Methyl-2-oxo-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-2H-pyridin-1-yl)acetamide; 1,3-Dimethyl-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyridin-2-one; (2-Oxo-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-2H-pyridin-1-yl)acetamide; 3-Methyl-5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyridin-2-one; 5-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyridin-2-one; 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(6-methoxypyridin-3-yl)ethanol; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid ethylamide; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid (1-ethylpropyl)amide; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid (1,2-dimethylpropyl)amide; 5-[1-(1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid (1,1-dimethylethyl)amide; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid (1-methylpropyl)amide; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid propylamide; 5-[1-(1-Allyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid (1-methylethyl)amide; 5-[1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid cyclobutyl ester; Cyclopentyl-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}methanone; Cyclobutyl-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}methanone; Cyclopropyl-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}methanone; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid cyclopentylmethylamide; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid isopropylmethylamide; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid cyclopropylamide; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid cyclopentylamide; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid cyclopropylmethylamide; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid isopropylamide; 5-[1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid cyclopentyl ester; 5-[1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid ethyl ester; 5-[1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid cyclopropylmethyl ester; 5-[2,2,2-Trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazole-1-carboxylic acid phenyl ester; 5-[1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoro-1-hydroxyethyl]indazole-1-carboxylic acid isopropyl ester; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-(1-phenylmethanesulfonyl-1H-indazol-5-yl)ethanol; 2-Phenyl-1-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}ethanone; 2-Thiophen-2-yl-1-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}ethanone; Phenyl-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}-methanone; 3-Methyl-1-{5-[2,2,2-trifluoro-1-hydroxy-1-(1-methyl-1H-indol-3-yl)ethyl]indazol-1-yl}butan-1-one; 1-(1-Benzenesulfonyl-1H-indazol-5-yl)-2,2,2-trifluoro-1-(1-methyl-1H-indol-3-yl)ethanol; 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)-1-[1-(propane-2-sulfonyl)-1H-indazol-5-yl]ethanol; 2,2,2-Trifluoro-1-(1-methanesulfonyl-1H-indazol-5-yl)-1-(1-methyl-1H-indol-3-yl)ethanol; 2,2,2-Trifluoro-1-(1H-indazol-5-yl)-1-(1-methyl-1H-indol-3-yl)ethanol; 2-Phenyl-1-[5-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)indazol-1-yl]ethanone; and 1-(1-Allyl-6-dimethylamino-1H-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol, or a tautomer, ester, amide, or a pharmaceutically acceptable salt thereof.