Patent ID: 7575740
Filing Date: 2009-08-18
Classification: A61L,A61P

Abstract:
1. A method for augmenting hard tissue, comprising applying to the tissue a composition comprising at least a first and a second precursor component having a functionality of at least three on each precursor component, wherein the first precursor component comprises at least m nucleophilic groups and the second precursor component comprises at least n electrophilic groups, wherein m+n is at least six, and wherein at least one of the first and second precursor components are selected from the group of monomers and oligomers, wherein the oligomers contain between two and ten monomer units, consisting of siloxane derivatives containing amino and/or thiol groups, cyclohexyl derivatives having formula  where n=6, R1=H or alkyl, R2″=alkyl; and X=—SH, tetra(3-mercaptopropyl)silane, derivatives of pentaerithritol that contain at least two alkyl chains with end-standing thiol and/or amine groups; derivatives of 1,1,1-tris-(hydroxy-methyl)propane that contain at least two alkyl chains with end-standing thiol and/or amine groups; derivatives of 1,1,1 tris-(hydroxymethyl)propanol that contain at least two alkyl chains with end-standing thiol and/or amine groups, derivatives of 1,1,1 tris(hydroxymethyl)propane that contain at least two acrylate groups, itaconoate groups, or itaconamide groups, derivatives of pentaerithritol that contain at least two acrylate groups, itaconoate groups, or itaconamide groups, and derivatives of triglycerol that contain at least two acrylate groups, itaconoate groups, or itaconamide groups, wherein the first and second precursor components crosslink at physiological temperatures over a period of time following application to form a biomaterial comprising a polymeric network having a Young's modulus E of at least 15 MPa measured at 0.35 mm/s and 10% strain 10 days after mixing the first and second precursor components and storage at 37° C.