Patent ID: 6204361
Filing Date: 2001-03-20
Classification: C07F,C07K

Abstract:
An in situ process for preparing a N-.varies.-protected amino acid fluoride which comprises mixing a N-.varies. protected amino acid or acylating derivative thereof with a fluorinating effective amount of an ionic fluoride salt in the presence of a coupling agent under conditions effective to form said protected amino acid fluoride, wherein the anion of the ionic fluoride salt has the formula:Ly (HF).sub.2 F.sup..crclbar., TG.sub.1 G.sub.2 G.sub.3 F.sub.2 -- or LF.sup..crclbar. ; whereinz is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;y is 0 or 1;L is TG.sub.1 G.sub.2 G.sub.3 G.sub.4 ;T is a group IV element selected from the group consisting of Si, Ge, Sn and Pb; andG.sub.1, G.sub.2, G.sub.3 and G.sub.4 are independently halogen, hydrogen,, alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl.