Patent ID: 7998943
Filing Date: 2011-08-16
Classification: A61K,A61P

Abstract:
1. A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme Core 2 GIcNAc-T comprising administering to the subject a therapeutically effective amount of an inhibitor of core 2 GIcNAc-T of formula (III): wherein Z is a steroid moiety of the formula (VI): the group Z incorporating additional group (VIa) or (VIc): wherein: when the steroid group incorporates additional group (VIa): R R R R R R R  represents either a single bond or a double bond; and wherein when the steroid group incorporates additional group (VIc): R R R R R X is O or NH; and  represents either a single bond or a double bond; or a pharmaceutically acceptable salt, ether or ester form thereof; and wherein the condition associated with detrimental activity of Core 2 GIcNAc-T is selected from the group consisting of: vascular diseases, autoimmune conditions, inflammatory conditions, Wiskott Aldrich syndrome and cancer metastasis.