Patent ID: 8496934
Filing Date: 2013-07-30
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating cachexia in a mammal, comprising administering to a mammal in need of treatment for cachexia a therapeutically effective amount of a GDF-8 specific antibody or antigen binding fragment thereof, said antibody or fragment comprising: an antibody variable heavy (VH) region comprising the first, second and third complementarity determining regions (CDR) from the VH region defined by the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:7; and an antibody variable light (VL) region comprising the first, second and third complementarity determining regions (CDR) from the VL region defined by the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:9.