Patent ID: 9080933
Filing Date: 2015-07-14
Classification: B01D,B03C,B82Y,C12N,C12Q,G01N,Y10T

Abstract:
1. A method of concentrating a target in a liquid, comprising applying a magnetic field to an aggregate in the liquid to provide a collected aggregate by magnetophoresis, wherein the aggregate comprises: (a) a stimuli-responsive magnetic nanoparticle comprising a first stimuli-responsive polymer attached to a magnetic core, wherein the stimuli-responsive magnetic nanoparticle does not include a capture moiety; and (b) a stimuli-responsive capture conjugate comprising a second stimuli-responsive polymer attached to a capture moiety, wherein the capture moiety is capable of binding to a target; wherein the aggregate is formed through associative interaction between the first stimuli-responsive polymer and the second stimuli-responsive polymer.