Patent ID: 6077954
Filing Date: 2000-06-20
Classification: C07D,C12Q,C40B,G01N

Abstract:
A compound having the formula: ##STR5## wherein: g.sup.1 is 1 to 4;g.sup.2 is 2 to 4;A is an aromatic, a heterocyclic, or alicyclic ring system;each x is, independently, 1 to 8;J is N, O, S, or a heterocyclic ring system having at least one nitrogen;t is 0 or 1;each T is, independently, a single bond, a methylene group or a group having the formula:{[CR.sup.1 R.sup.2 ].sub.m --(R.sup.5)--[CR.sup.1 R.sup.2 ].sub.n --[C(R.sup.6)].sub.p --(E)--}.sub.q --R.sup.6 is .dbd.O, .dbd.S, .dbd.NR.sup.3 ;R.sup.5 and E, independently, are a single bond, CH.dbd.CH, C.dbd.C, O, S, NR.sup.3, SO.sub.2, or C.sub.6 -C.sub.14 aryl;each R.sup.1, R.sup.2 and R.sup.3 is, independently, H, alkyl or haloalkyl having 1 to 10 carbon atoms, alkenyl having 2 to 10 carbon atoms, alkynyl having 2 to 10 carbon atoms, or aryl having 6 to 14 carbon atoms;m and n, independently, are zero to 5;p is zero or 1;q is 1 to 10; andeach L is, independently, H, C.sub.2 -C.sub.10 alkyl or substituted alkyl, C.sub.2 -C.sub.10 alkenyl or substituted alkenyl, C.sub.2 -C.sub.10 alkynyl or substituted alkynyl, C.sub.4 -C.sub.7 carbocyclic alkyl or substituted carbocyclic alkyl, alkenyl carbocyclic or substituted alkenyl carbocyclic, alkynyl carbocyclic or substituted alkynyl carbocyclic, or C.sub.6 -C.sub.14 aryl or substituted aryl where the substituent groups are selected from hydroxyl (OH), alkoxy, alcohol, benzyl, phenyl, nitro (NO.sub.2), thiol (SH), thioalkoxy, halogen, alkyl, aryl, alkenyl, and alkynyl groups; or L is phthalimido, an ether having 2 to 10 carbon atoms and 1 to 4 oxygen or sulfur atoms, a nitrogen containing heterocycle, a sulfur containing heterocycle, an oxygen containing heterocycle, a metal coordination group, a conjugate group, halogen, hydroxyl, thiol, keto (C.dbd.O), carboxyl (COOH), amide (CONR.sup.1), amidine (C(.dbd.NH)NR.sup.2 R.sup.3), guanidine (NHC (.dbd.NH)NR.sup.2 R.sup.3), glutamyl (R.sup.1 OOCCH(NR.sup.2 R.sup.3)(CH.sub.2).sub.2 C(.dbd.O), nitrate (ONO.sub.2), nitro, nitrile (CN), trifluoromethyl (CF.sub.3), trifluoromethoxy (OCF.sub.3), O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aralkyl, S-aralkyl, NH-aralkyl, amino (NH.sub.2), azido (N.sub.3), hydrazino (NHNH.sub.2), hydroxylamino (ONH.sub.2), sulfoxide (SO), sulfone (SO.sub.2), sulfide (S--), disulfide (S--S), silyl, a nucleosidic base, an amino acid side chain, a carbohydrate, a drug, or a group capable of hydrogen bonding;with the proviso that when A is 2,6-disubstituted pyridine with g.sup.1 equal to 2 and g.sup.2 equal to 2, and having 6 of said L groups, then not more than 3 of said L groups are H or para-toluenesulfonyl;with the further proviso that not more than one --T--L is H.