Patent ID: 6689802
Filing Date: 2004-02-10
Classification: A61P,C07D

Abstract:
A crystalline polymorph of an epothilone analog represented by the formula comprising Form A characterized by:unit cell parameters approximately equal to the following: Cell dimensionsa = 14.152(6) Ã¥b = 30.72(2) Ã¥c = 6.212(3) Ã¥Volume = 2701(4) A3Space groupP212121OrthorhombicMolecules/unit cell4Density (calculated) (g/cm3)1.247Melting point182-185Â° C. (decomposition); andcharacteristic peaks in the powder x-ray diffraction pattern at values of two theta (CuK&agr; &lgr;=1.5406 Ã¥ at 22Â° C.): 5.69, 6.76, 8.38, 11.43, 12.74, 13.62, 14.35, 15.09, 15.66, 16.43, 17.16, 17.66, 18.31, 19.03, 19.54, 20.57, 21.06, 21.29, 22.31, 23.02, 23.66, 24.18, 14.98, 25.50, 26.23, 26.23, 26.46, 27.59, 28.89, 29.58, 30.32, 31.08 and 31.52.