Patent ID: 6514535
Filing Date: 2003-02-04
Classification: A61K,A61L,A61P

Abstract:
A bioadhesive polymer having a bioadhesion capacity of at least 100 g s, the polymer being capable of degradation inside a mammal into discrete segments which are essentially non-degradable yet essentially excretable, the polymer being composed of polymer backbones and crosslinks bonding the polymer backbones to one another sufficiently so that the polymer is capable of forming a hydrogel in water,the polymer backbones having a molecular weight of less than 45,000 Daltons and a hydrodynamic radius of less than about 40 Angstroms and being composed of one or more polymerized or copolymerized monomer selected from the group consisting of allyl amine, acryl amine, amides, N- vinyl pyrrolidone, hydroxyethylmethacrylate, acrylic acid, methacrylic acid, maleic acid, salts of these acids and esters of these acids, maleic anhydride, C1-C5 alkyl vinyl ether and a neutral but hydrophilic comonomer, the crosslinks containing ester, peptide, disulfide or thiol links which are degradable in a mammal by enzymatic cleavage, exchange reactions with mucin, reduction or oxidation.