Patent ID: 9029337
Filing Date: 2015-05-12
Classification: A61P,C12N,C12Y

Abstract:
1. A compound comprising a single-stranded modified antisense oligonucleotide consisting of 12 to 30 linked nucleosides targeted to a human Factor 7 nucleic acid, wherein the oligonucleotide has a sequence that is least 90% complementary to SEQ ID NO: 1 as measured over the entirety of said oligonucleotide, and wherein the oligonucleotide comprises: a gap segment consisting of linked deoxynucleosides; a 5′ wing segment consisting of linked nucleosides; a 3′ wing segment consisting of linked nucleosides; wherein the gap segment is positioned immediately adjacent to and between the 5′ wing segment and the 3′ wing segment and wherein each nucleoside of each wing segment comprises a modified sugar.