Patent ID: 7371773
Filing Date: 2008-05-13
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of inhibiting a breast cancer resistance protein (BCRP) comprising administering to a patient an effective amount of a diphenylacrylonitrile derivative represented by the following formula (1) or a salt thereof: wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (—NHCOCH 3 group), a cyano group (—CN group), a formyl group (—CHO group), —COOR 1 (R 1 is hydrogen or C 1 -C 4 alkyl), —O(CH 2 ) n COOR 2 (n=1-7: R 2 is hydrogen or C 1 -C 4 alkyl), —OOCCH 2 CH 2 COOR 3 (R 3 is hydrogen, C 1 -C 4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C 1 -C 8 alkoxy group, a C 1 -C 4 alkyl group, a halogen atom, a C 1 -C 4 alkoxy C 1 -C 4 alkoxy C 1 -C 4 alkoxy group, a C 2 -C 8 acyloxy group, a C 2 -C 8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (—OP(O)(OH) 2 ) or a salt thereof, a sulfate group (—OSO 3 H) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group.