Patent ID: 8772250
Filing Date: 2014-07-08
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating an ischemic injury or an ischemia-reperfusion injury in a subject in need thereof, comprising administering to the subject at least two doses of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 in the compound are each independently H or a hydrolyzable group and the compound, or pharmaceutically acceptable salt thereof, is at least 90% enantiomerically pure, the method comprising: administering to the subject a non-final dose of the compound, or a pharmaceutically acceptable salt thereof, and a final dose of the compound, or a pharmaceutically acceptable salt thereof, prior to the injury, wherein: (a) the final dose is administered immediately prior to the injury; and (b) the non-final dose and the final dose are administered at a dosage interval that potentiates the efficacy of the compound for treating the injury relative to a single-dose administration of the compound.