Patent ID: 6750253
Filing Date: 2004-06-15
Classification: A61P,C07C

Abstract:
A compound of the formula I wherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro, provided that when R1 represents one substituent, it is in the ortho position, and when R1 represents more than one substituent, at least one R1 substituent is in the ortho position;R2 is one substituent in the ortho position, said substituent being selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro; R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, phenyl, cyano, carboxy, or carbamoyl; R4 represents hydrogen, (C1-C3)alkyl, or allyl; Q represents a bond, â€”SO2â€”, or â€”C(R6)(R7)(â€”Oâ€”C&boxH;O)â€”, in which formula R6 and R7 independently represent hydrogen, trifluoromethyl, or (C1-C4)alkyl; Y represents (C1-C15)alkyl, (C2-C15)olefinic group, (C3-C10)carbocyclic group, or phenyl, any of which is optionally substituted by one or more, same or different substituents represented by the formula R5; or Y represents a group of formula â€”(Zâ€”O)nâ€”Z, where Z is a (C1-C3)alkyl and n is an integer >1, and no continuous linear sequence of atoms in the group Y exceeds 15; R5 represents halogen, hydroxy, mercapto, trifluoromethyl, (C1-C4)alkyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, â€”COOH, â€”CONH2, â€”CONHRâ€², or â€”CONRRâ€² wherein R and Râ€² stands for (C1-C3)alkyl; X represents oxygen or sulphur, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.