Patent ID: 6774130
Filing Date: 2004-08-10
Classification: A61K,C07D

Abstract:
A therapeutic compound, including resolved enantiomers, diastereomers, tautomers, salts and solvates thereof, comprising the following formula (I): wherein: X is N and Y is N or N(R3); Z is â€”C(R3); R1 is substituted or unsubstituted C(5-9)hydroxyalkyl; R2 and R3 are independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(2-20)tetraaminoalkyl, C(5-15)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1-11)alkoxyalkyl, and C(1-20)dialkoxyalkyl; and â€” âˆ’ â€” âˆ’ represents a double or single bond; with the proviso that R1 is not an &ohgr;-1-hydroxyalkyl group having from 5 to 9 carbon atoms when R3 is hydrogen or methyl.