Patent ID: 6297256
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound of Formula I: ##STR14##or a pharmaceutically acceptable non-toxic salt thereof, wherein:n is 0 or an integer of from 1-3;X is nitrogen or CR', where R' is lower hydrocarbyl or hydrogen;R is hydrogen, lower hydrocarbyl, hydroxy, lower alkoxy, hydroxyhydrocarbyl, aminohydrocarbyl, or mono or di(C.sub.1 -C.sub.6 hydrocarbyl)aminohydrocarbyl;A and B are the same or different and represent hydrogen, or straight or branched chain lower hydrocarbyl having 1-6 carbon atoms;R.sub.A and R.sub.B, together with the two carbon atoms to which they are attached, form a 5-7 membered aryl group, or a 5-7 membered saturated or unsaturated ring optionally containing 1 or 2 nitrogens, or a heteroaryl ring having 5-7 members and containing at least one nitrogen, wherein each ring may be optionally substituted with 1, 2, or 3 substituents independently selected from halogen, hydroxy, C.sub.1 -C.sub.6 alkyl, alkoxy, amino, or mono or di(C.sub.1 -C.sub.6 alkyl)amino;W is aryl, heteroaryl, 2- or 3-thienyl, or 2-, 3-, or 4-pyridyl, each of which may be mono-, di- or trisubstituted independently with halogen, hydroxy, (C.sub.1 -C.sub.6)lower hydrocarbyl, (C.sub.1 -C.sub.6)lower alkoxy, amino, or mono- or di (C.sub.1 -C.sub.6)hydrocarbylamino.