Patent ID: 6818742
Filing Date: 2004-11-16
Classification: A61K,C07H,C07K,G01N

Abstract:
An aminopolycarboxylate-appended peptide for radioiodinating an antibody selected from the group consisting of:MCC-Lys (MCC)-Lys((1-(p-CSNH)benzyl)DTPA)-D-Tyr-D-Tyr-D-Lys((1-(p-CSNH)benzyl)DTPA)-OH; ABG-Lys(MCC)-Lys((1-(p-CSNH)benzyl)DTPA)-D-Tyr-D-Lys((1-(p-CSNH)benzyl)DTPA)-OH; ABG-Asp-D-Tyr-D-Lys((1-(p-CSNH)benzyl)DTPA)-OH; ABG-Lys(MCC)-Asp-D-Tyr-D-Lys((1(p-CSNH)benzyl)DTPA)-OH; ABG-Asp-D-Tyr-D-Lys((1-(p-CSNH)benzyl)DTPA)-OH; and ABG-Lys(MMC)-Asp-D-Tyr-D-Lys((1-(p-CSNH)benzyl)DTPA)-OH; wherein ABG is an antibody binding group, MCC is a 4-(N-maleimidomethyl)-cyclohexane-1-carobnyl, MMC is a maleimidomethylcarbonyl and DTPA is a diethylenetriaminepentaacetic acid.