Patent ID: 8540979
Filing Date: 2013-09-24
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of generating an immune response in an individual with cancer against cells expressing a tumor antigen, comprising administering an effective amount of an adenoviral expression vector, said vector comprising a transcription unit encoding a polypeptide, said polypeptide comprising from the amino terminus a secretory signal sequence, a tumor antigen, and a CD40 ligand wherein said tumor antigen is different from said CD40 ligand and wherein said CD40 ligand is missing all or substantially all of the transmembrane domain rendering the CD40 ligand secretable, and wherein said polypeptide is adapted to elicit Class I restricted cellular immunity, and whereby the generation of said immune response is achieved by injection of the vector directly into tumor nodules of the individual, expressing the tumor antigen.