Patent ID: 6458767
Filing Date: 2002-10-01
Classification: A61K,C07K

Abstract:
A method of treating kidney disease in a subject having kidney disease, said method comprising: administering to the subject a pharmaceutically effective amount of a purified peptide, comprising an amino acid sequence Leu-Ser-Lys-Leu (SEQ ID NO. 21), wherein said peptide is derived from thrombospondin, and is operative in inhibiting activation of TGF-&bgr;, or a functional derivative thereof, wherein said functional derivative has a free moiety selected from the group consisting of â€”OH, â€”SH, â€”NH2 and â€”COOH, and a substitution of a hydroxyl by a halogen, and derivatives consisting of ethers, esters, amides not normally part of the peptide.