Patent ID: 8815277
Filing Date: 2014-08-26
Classification: A61K,A61L,A61P

Abstract:
1. A composition of enzyme-triggered in situ-forming injectable hydrogel, represented by the following Chemical Formula 2, comprising: two or more homogeneous or heterogeneous polymers, represented by the following Chemical Formula 1, bonding to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with one of the phenol or aniline moieties by a linker, wherein the polymers are in situ crosslinked in vivo in the presence of horseradish peroxidase and hydrogen peroxide to form the hydrogel, wherein, R is hydroxyl or amine, and L is selected from the group consisting of polyethyleneglycol (PEG), polyethylene oxide (PEO), polyethylenimine (PEI), polypropylene oxide (PPO), polyvinyl alcohol (PVA), poly(N-isopropylacrylamide) (polyNIPAAM), polyfumarate, polyorganophosphazene, polyacrylic acid (polyAAc), polyacrylsulfonate, poly hydroxyethylmethacrylate(PolyHEMA), and copolymers thereof.