Patent ID: 9206230
Filing Date: 2015-12-08
Classification: C07C,C07K

Abstract:
1. A method of producing a peptide by a liquid phase synthesis process, comprising: (1) removing a protecting group of a N-terminal of a C-protected amino acid or C-protected peptide, wherein a benzylic compound represented by formula (I): wherein Y is a hydroxyl group or an —NHR group; R is a hydrogen atom, an alkyl group or an aralkyl group; R each R n is an integer of 0-4, is condensed with a C-terminal of a N-protected amino acid or N-protected peptide; (2) condensing the N-terminal of the amino acid or peptide from (1) with a N-protected amino acid or N-protected peptide to produce a peptide, and (3) precipitating the peptide from (2).