Patent ID: 8962545
Filing Date: 2015-02-24
Classification: A23L,A23V,A61K,A61P,C07D,C07K,C12Y,G01N,Y02A

Abstract:
1. A method for treating a foodstuff comprising wheat gluten proteins, said method comprising contacting said foodstuff comprising wheat gluten proteins in vitro with a glutenase, wherein said glutenase has a k cat /K m of at least 250 s −1 /m −1 for cleaving one or both of the oligopeptides of SEQ ID NO:3 and SEQ ID NO:12 under physiologic conditions into fragments shorter than 8 amino acids; to prepare a pre-treated foodstuff that is less toxic to a Celiac sprue and/or dermatitis herpetiformis patient, relative to the untreated foodstuff, and contains enzymatically active glutenase when ingested by said patient.