Patent ID: 6605442
Filing Date: 2003-08-12
Classification: A61K,C07K,C12N,Y02A

Abstract:
A method of identifying a potential drug that has the ability to modulate the level of phosphorylation of a receptor recognition factor in a target mammalian cell comprising:(a) adding a ligand to the target mammalian cell in the presence of the potential drug, wherein the target mammalian cell contains a receptor, and the receptor recognition factor; and wherein, in the absence of the potential drug, the binding of the receptor by the ligand results in the phosphorylation of the receptor recognition factor; (b) determining the level of phosphorylation of the receptor recognition factor in the presence of the potential drug; and (c) comparing the level of phosphorylation of the receptor recognition factor determined in step (b) with the level of phosphorylation determined in the absence of the potential drug; wherein the potential drug is identified as having the ability to modulate the level of phosphorylation of the receptor recognition factor in the target mammalian cell when said comparing indicates a change in the level of phosphorylation.