Patent ID: 8835616
Filing Date: 2014-09-16
Classification: C12N

Abstract:
1. A nucleic acid encoding a synthetic polypeptide, the polypeptide comprising: a first, non-lantibiotic export signal peptide that is SEQ ID NO:46 or a signal for the secretory (Sec) system from a second, lantibiotic leader peptide that is recognized by a lantibiotic dehydratase selected from the group consisting of lantibiotic dehydratase (LanB) and lantibiotic bifunctional enzyme (LanM) dehydratase; and a third peptide of interest comprising at least one serine or threonine residue that can be posttranslationally dehydrated by LanB, wherein the peptide of interest is positioned C-terminally of both the non-lantibiotic export signal peptide and the lantibiotic leader peptide.