Patent ID: 7547681
Filing Date: 2009-06-16
Classification: A61K,C07K

Abstract:
1. A composition for eliciting antibodies specific for a cell surface receptor antigen, comprising: a) a first recombinant expression construct containing at least one promoter operably linked to a nucleic acid sequence encoding a cell surface receptor antigen, wherein the cell surface receptor antigen is selected from the group consisting of HER1, HER2, HER3 and HER4; b) a second recombinant expression construct containing at least one promoter operably linked to a nucleic acid sequence encoding a first immune response altering molecule wherein said first immune response altering molecule comprises 4-1BB-ligand; and c) a nucleic acid sequence encoding a second immune response altering molecule selected from the group consisting of CD80/B7.1 and CD86/B7.2.