Patent ID: 6482986
Filing Date: 2002-11-19
Classification: A61P,C07C

Abstract:
A compound of formula: in which:A represents a group chosen from the following: â€”Câ‰¡Câ€”, â€”CH&boxH;CHâ€”; â€”CH2â€”CH2â€”n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom or a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or fluorine atom; R1 represents a cyclohexyl group monosubstituted, disubstituted, trisubstituted or tetrasubstituted with a methyl group; a phenyl group monosubstituted or disubstituted with a fluorine or chlorine atom or with a methoxy group; a cycloheptyl, tert-butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl or 1- or 2-adamantyl or adamantan-2-ol group; or R1 represents a phenyl group, it being understood that, in this case, X and Y are other than hydrogen; R2 represents a hydrogen atom or a (C1-C4)alkyl group optionally substituted with a trifluoromethyl group; R3 represents a (C5-C7)cycloalkyl; and the addition salts of these compounds with pharmaceutically acceptable acids, as well as the solvates and hydrates thereof.