Patent ID: 6350778
Filing Date: 2002-02-26
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of formula I in which:X is oxygen, sulfur, or cyanoimino; Y is â€”(CR(5)2)nâ€”; Z is NH or oxygen; the residues A(1), A(2), and A(3), which are independent of one another and can be identical or different, are hydrogen, halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, methylenedioxy, formyl, or trifluoromethyl; R(1) is a) (C1-C4)-alkyl; b) â€”Oâ€”(C1-C4)-alkyl; c) â€”Oâ€”(C1-C4)-alkyl-E(1)â€”(C1-C4)-alkyl-D(1), in which D(1) is hydrogen or â€”E(2)â€”(C1-C4)-alkyl-D(2), in which D(2) is hydrogen or â€”E(3)â€”(C1-C4)-alkyl, where E(1), E(2), and E(3), which are independent of one another and can be identical or different, are O, S, or NH; d) â€”Oâ€”(C1-C4)-alkyl which is substituted by a residue of a saturated 4-membered to 7-membered heterocycle which contains one or two oxygens as ring heteroatoms; e) â€”Oâ€”(C2-C4)-alkenyl; f) â€”Oâ€”(C1-C4)-alkyl-phenyl in which the phenyl group is unsubstituted or substituted by one or two identical or different substituents selected from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl; g) â€”O-phenyl which is unsubstituted or substituted by one or two identical or different substituents selected from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl; h) halogen; i) phenyl which is unsubstituted or substituted by one or two identical or different substituents selected from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, â€”S(O)mâ€”(C1-C4)-alkyl, phenyl, amino, hydroxy, nitro, trifluoromethyl, cyano, hydroxycarbonyl, carbamoyl, (C1-C4)-alkoxycarbonyl, and formyl; j) (C2-C5)-alkenyl which is unsubstituted or substituted by a substituent selected from phenyl, cyano, hydroxycarbonyl, and (C1-C4)-alkoxycarbonyl; k) (C2-C5)-alkynyl which is unsubstituted or substituted by a substituent selected from phenyl and (C1-C4)-alkoxy; l) monocyclic or bicyclic heteroaryl having one or two identical or different ring heteroatoms selected from oxygen, sulfur, and nitrogen; m) â€”S(O)m-phenyl which is unsubstituted or substituted by one or two identical or different substituents selected from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl; or n) â€”S(O)mâ€”(C1-C4)-alkyl; R(2) is hydrogen, (C1-C6)-alkyl, or (C3-C7)-cycloalkyl, but is not hydrogen if Z is oxygen; the residues R(3) and R(4), which are independent of one another and can be identical or different, are phenyl which is unsubstituted or substituted by one or two identical or different substituents selected from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl, hydrogen, or (C1-C4)-alkyl; the residues R(5), which are independent of one another and can be identical or different, are hydrogen or (C1-C3)-alkyl; m is 0, 1, or 2; n is 1, 2, 3, or 4; in any stereoisomeric form or mixture thereof in any ratio, or a physiologically tolerable salt thereof, where compounds of formula I are excluded in which, simultaneously, X is oxygen, Z is NH, R(1) is halogen, (C1-C4)-alkyl, or â€”Oâ€”(C1-C4)-alkyl, and R(2) is (C2-C6)-alkyl or (C5-C7)-cycloalkyl.