Patent ID: 7956072
Filing Date: 2011-06-07
Classification: A61K,A61P,C07D

Abstract:
1. A method for promoting corneal neuritogenesis, which comprises administering topically to the eye an effective amount of an amide compound represented by the formula (I): wherein Ra is a formula: wherein in the formulas (a) and (b), R is hydrogen, alkyl, or cycloalkyl, cycloalkylalkyl, phenyl or aralkyl, each optionally having substituent(s) on the ring, or a formula: wherein R wherein R R or R R or R and R R R A is a formula: wherein R l, m, n are each 0 or an integer of 1-3, and in the formula (c), L is hydrogen, alkyl, aminoalkyl, mono- or di-alkylaminoalkyl, tetrahydrofurfuryl, carbamoylalkyl, phthalimidoalkyl, amidino, or a formula: wherein B is hydrogen, alkyl, alkoxy, aralkyl, aralkyloxy, aminoalkyl, hydroxyalkyl, alkanoyloxyalkyl, alkoxycarbonylalkyl, α-aminobenzyl, furyl, pyridyl, phenyl, phenylamino, styryl or imidazopyridyl, Q W is alkylene, Q X is alkylene, Q Y is a single bond, alkylene or alkenylene, a bond shown by a broken line and a solid line in the formula (c) is a single bond or a double bond, and R Rb is hydrogen, alkyl, aralkyl, aminoalkyl or mono- or di-alkylaminoalkyl, and Rc is a nitrogen-containing heterocycle optionally having substituent(s), an isomer thereof and/or a pharmaceutically acceptable acid addition salt thereof, or a prodrug thereof, to a subject in need of promotion of corneal neuritogenesis.