Patent ID: 6697739
Filing Date: 2004-02-24
Classification: G16B

Abstract:
A method for the analysis of linkage disequilibrium between at least one marker locus and a disease or trait locus of interest, comprising the steps of:(a) providing a data set comprising a marker locus with at least two alleles for a plurality of extended pedigrees, where N is the number of unrelated extended pedigrees, at least one of said extended pedigrees containing at least one informative nuclear family or informative discordant sibship; then (b) determining a random variable XT for each triad within an informative nuclear family for each allele Mi; (c) determining a random variable XS for each DSP within an informative discordant sibship for each allele Mi; (d) determining a summary random variable D from XS and XT for each of said extended pedigrees for each allele Mi, and then; (e) determining a statistic T from each of said summary random variables D from each of said N unrelated extended pedigrees for each allele Mi an extreme value for T indicating greater linkage disequilibrium.