Patent ID: 7005270
Filing Date: 2006-02-28
Classification: C07K,G01N

Abstract:
1. A method of detecting the presence of Treponema pallidum or anti-treponemal antibodies in a biological sample, comprising: contacting an isolated Treponema pallidum acidic repeat protein or one or more isolated, immunogenic Treponema pallidum peptide(s) of the acidic repeat protein with an antibody-containing biological sample, wherein the acidic repeat protein or the isolated immunogenic Treponema pallidum peptide(s) of the acidic repeat protein comprises the amino acid sequence set forth in SEQ ID NO: 2, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 22, 24 or 26 and detecting formation of a complex between the immunogenic protein or peptide and the antibody, wherein the presence of the complex indicates the presence of Treponema pallidum or anti-treponemal antibodies in the biological sample.