Patent ID: 6060616
Filing Date: 2000-05-09
Classification: A61P,C07C,C07F

Abstract:
A bis-platinum(II) complex comprising formula (I): whereintwo of the X, Y, and Z ligands attached to each platinum atom are ammonia and the other ligand is selected from the group consisting of chloride, bromide, iodide, and a (C.sub.1 -C.sub.4)acyloxy group;n and m are each independently an integer of two to eight;p is the integer one or two;A is --B.sub.1 -- or --B.sub.2 --(CH.sub.2).sub.r --B.sub.2 --, wherein r is an integer of two to eight, B.sub.1 is selected from the group consisting of --NR.sup.1 --CO--, --CO--NR.sup.1 --, --NR.sup.1 --SO.sub.2 --NR.sup.1 --, --NR.sup.1 --C(=NR.sup.2)--NR.sup.1 --, --NR.sup.1 --CO--CO--NR.sup.1 --, and --NR.sup.1 --CO--NR.sup.1 --, and B.sub.2 is --NR.sup.1 --CO-- or --CO--NR.sup.1 --, wherein R.sup.1 is hydrogen or a (C.sub.1 -C.sub.4)alkyl group, and wherein R.sup.2 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.4)alkyl, and tert-butyloxycarbonyl; andQ.sup.-p is an anion selected from the group consisting of chloride, bromide, iodide, nitrate, sulfate, hydrogen sulfate and perchlorate.