Patent ID: 6565873
Filing Date: 2003-05-20
Classification: A61K,A61Q,B82Y

Abstract:
A controlled release delivery system for delivery to biological surfaces comprising an oral cavity or mucous membranes of various tissues, said system comprising:a plurality of solid nano-particles, each of said solid nano-particles comprising a core formed of a hydrophobic material selected from the group consisting of natural waxes, synthetic waxes, fatty acid esters, fatty alcohols, solid hydrogenated plant oils, biodegradable natural polymers and synthetic polymers, and an effective amount of a first active agent contained therein and a bioadhesive positively charged surfactant entrapped on a surface of each of said solid nano-particles surrounding said core, wherein said positively charged surfactant is selected from the group consisting of straight-chain alkylammonium compounds, cyclic alkylammonium compounds, petroleum derived cationics, and polymeric cationic materials.