Patent ID: 6225339
Filing Date: 2001-05-01
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of formula (I): ##STR6##wherein the dotted line is an optional bond;R.sup.1 is O or OH;X is O or N, or absent;R.sup.2 is H, C.sub.1 -C.sub.5 alkyl or benzyl, or absent;R.sup.3 is H, OH, C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.3 alkenyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio;R.sup.4 is H or C.sub.1 -C.sub.5 alkoxy;R.sup.5 is H, C.sub.1 -C.sub.4 alkylthio or C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.4 alkylthio, or absent;R.sup.6 is H or OH; orR.sup.5 and R.sup.6 form, together with the carbon atom to which they are attached, an oxirane ring;R.sup.7 and R.sup.8 form, together with the carbon to which they are attached, a lactone ring;with proviso thatwhen X is O and R.sup.2 is absent, the dotted line between 3- and 4-positions is a single bond;when R.sup.1 is O; and R.sup.5 and R.sup.6 form, together with the carbon atom to which they are attached, an oxirane ring; R.sup.3 is not methoxy.