Patent ID: 6436960
Filing Date: 2002-08-20
Classification: A61P,C07D

Abstract:
A piperidine derivative represented by the following formula (1): in whichA represents hydrogen, lower alkyl, or â€ƒwherein B represents CH2, C&boxH;O or SO2, and D represents a radical selected from the following group: â€ƒIn the definition for the substituent D, m denotes an integer of 0 to 3, n denotes an integer of 1 to 3, X represents hydrogen, phenyl, phenoxy, lower alkyl, lower alkoxy, halogen, nitro, or amino which is optionally substituted by benzyl or lower alkyl, R1 and R2 independently of one another represent hydrogen, lower alkyl, C3-C6-cycloalkyl, lower alkyl substituted by C3-C6-cycloalkyl, aryl or heteroaryl, E represents hydrogen, phenyl, naphthyl or â€ƒwherein R3 and R4 independently of one another represent hydrogen, lower alkyl, aril or, â€ƒ(wherein Y represents O or S, nâ€² denotes an integer of 2 to 4, and R5 represents lower alkyl), G represents a radical selected from the following group: â€ƒwherein Z represents O, S, SO2 or Nâ€”R6 (wherein R6 represents hydrogen or lower alkyl), R7 and R8 independently of one another represent hydrogen, lower alkyl, lower alkoxy, halogen, cyano, hydroxycarbonyl, aminocarbonyl, aminothiocarbonyl, hydroxy, phenyl or phenoxy, or a pharmaceutically acceptable salt thereof.