Patent ID: 7700126
Filing Date: 2010-04-20
Classification: A61K,A61L

Abstract:
1. A composition comprising protoelastin made from human recombinant tropoelastin, wherein the human recombinant tropoelastin is selected from the group consisting of full length tropoelastin; one or more splice variants of tropoelastin selected from the group consisting of an isoform lacking domains 22 and 26A and an isoform lacking domain 22 but including domain 26A; chemically modified tropoelastin selected from the group consisting of acetylated tropoelastin, pegylated tropoelastin, tropoelastin having a chemical or peptide linker bound thereto, and methylated tropoelastin; and recombinant tropoelastin fragments selected from the group consisting of a fragment encompassing the N-terminus domain but not all of the C-terminus domain, a fragment not encompassing all of the N-terminus domain or C-terminus domain, a fragment encompassing the C-terminus domain but not all of the N-terminus domain, and a fragment encompassing domain 36; wherein the protoelastin is made by (a) covalently binding tropoelastin to a metal, ceramic, bone, or polymeric substrate; (b) laminating tropoelastin to a synthetic non-natural polymer to form a tropoelastin-polymer laminate; (c) blending tropoelastin with a synthetic non-natural polymer; or (d) a combination thereof.