Patent ID: 8097251
Filing Date: 2012-01-17
Classification: A61K,A61P,C07K

Abstract:
1. A macromolecule that is a functional heavy chain antibody, a functional single domain heavy chain antibody or a functional VH domain comprising a first immunoglobulin single variable domain having a first antigen or epitope binding specificity and a second immunoglobulin single variable domain having a second antigen or epitope binding specificity wherein one or both of said first and second variable domains bind to human serum albumin, and the first and the second immunoglobulin variable domains are heavy chain variable domains, wherein the first or second variable domains comprises a sequence selected from SEQ ID NOs. 112-116, and wherein the amino acid at position 103 of the functional heavy chain antibody, the functional single domain heavy chain antibody or the functional VH domain is arginine (R) or wherein the amino acid at position 103 is replaced with arginine (R), said position 103 determined according to Kabat numbering.