Patent ID: 6495678
Filing Date: 2002-12-17
Classification: A61K,C07D,C07H

Abstract:
A method of suppressing an immune response comprising administering to a patient in need of treatment an effective amount of a glucopyranose compound of the formula (I): wherein R is hydrogen, hydroxy or C1-4 alkoxy,G is (1) in which R1 is a single bond or C2-20 oxycarbonylalkyl, R2 is hydrogen or in which R8 is hydrogen, C1-7 alkyl, C1-7 alkoxy or a halogen atom, m is 1, 2, or 3; R3 is C1-20 alkylene, R4 is hydrogen or in which R9 is hydrogen, C1-7 alkyl, C1-7 alkoxy or a halogen atom, n is 1, 2, or 3; or (2) in which Y is a single bond or C1-4 alkylene, and p and q are each independently an integer of from 6-12; R5 is C2-20 oxycarbonylalkyl, R6 is hydrogen or in which R8 and m are as hereinbefore defined; or R5â€”R6 is in which Z is a single bond or C1-4 alkylene, and r and s are each independently an integer of from 6-12; R7 is hydrogen, methyl, hydroxymethyl or sulfoxymethyl; with the proviso that (1) R2, R4 and R6 are not hydrogen at the same time, (2) when R1 is C2-20 oxycarbonylalkyl, then R2 bonds to alkyl in R1, (3) when R5 is C2-20 oxycarbonylalkyl, then R6 bonds to alkyl in R5; or a non-toxic salt thereof.