Patent ID: 6194439
Filing Date: 2001-02-27
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I ##STR24##whereinQ is ##STR25##at least three and no more than four of R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are OH, the remainder being H;R.sub.9 is H or halo;Z.sub.1 is H, benzyl, alkyl(C.sub.1 -C.sub.4), --(CH.sub.2).sub.n --phenyl--R.sub.22, --(CH.sub.2).sub.n --dichlorophenyl, ##STR26##--SO.sub.2 --R.sub.21, --CH.sub.2 --pyridyl or ##STR27##wherein n is 0-3;R.sub.20 is H, t-butyl, CF.sub.3, --SO.sub.2 --alkyl(C.sub.1 -C.sub.4), halo, alkyl(C.sub.1 -C.sub.4), phenyl or NO.sub.2 ;R.sub.21 is phenyl, alkyl(C.sub.1 -C.sub.4), benzyl, nitrophenyl, dichlorophenyl or halophenyl;R.sub.22 is --C.tbd.N, CF.sub.3, phenylsulfonyl, halo or alkyl(C.sub.1 -C.sub.4); andthe pharmaceutically-acceptable cationic salts and prodrugs thereof.