Patent ID: 6951844
Filing Date: 2005-10-04
Classification: A61K,C07C

Abstract:
1. A pharmaceutical composition comprising a compound of the formula I wherein R the aryl group may optionally be substituted with one or more substituent selected from the group consisting of hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, trifluoromethyl, trifluoromethoxy, alkynyl, hydroxy, amino, nitro, cyano, aryl, cycloalkyl, heteroaryl, carboxyl or an alkyl ester thereof, and carboxamide; the C the C R the C the C R n is an integer from 0 to 4; and m is an integer from 1 to 4, including all stereolsomers thereof, prodrug esters thereof, and pharmaceutically acceptable salts thereof, and at least one additional therapeutic agent selected from the group consisting of other compounds of formula I, metformin, phenformin, glimepiride, glyburide, glicazide, chlorpropamide, glipizide, troglitazone, darglitazone, englitazone, rosiglitazone, pioglitazone, insulin, acarbose, miglitol, GLP-1, alendronate, risedronate, raloxifene, calcitonin, orlistat, sibutramine, topiramate, axokine, dexamphetamine, phentermine, phenylpropanolamine, mazindol, diethylstilbestrol, theophylline, enkephalins, sulbenox, GHRP-6, GHRP-2, GHRP-1, IGF-1, IGF-2, clonidine, sumatriptan, physostigmine, pyndostigmine, parathyroid hormone, estrogen, testosterone, tamoxifen, levonorgestrel, medroxyprogesterone acetate, prednisone, dexamethasone, aspirin, indomethacin, ibuprofen, piroxicam, mycophenolate, infliximab, budesonide, clofazimine, priliximab, diazepam, lorazepam, buspirone, oxazepam, hydroxyzine pamoate, citalopram, fluoxetine, nefazodone, sertraline, tretinoin, diltiazem, verapamil, nifedipine, amlodipine, mybefradil, chlorothiazide, hydrochlorothiazide, flumethiazide, hydroflumethiazide, bendroflumethiazide, methylchlorothiazide, trichloromethiazide, polythiazide, benzthiazide, ethacrynic acid, chlorthalidone, furosemide, musolimine, bumetanide, triamterene, amiloride, spironolactone, captopril, zofenapril, pentopril, quinapril, ramipril, lisinopril, losartan, irbesartan, valsartan, sitaxsentan, atrasentan, omaprilat, gemopatrilat, digitalis, ouabain, 9-[4-[4-[[2-(2,2,2-trifluoroethoxy)benzoyl]amino]-1-piperidinyl]butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide, mevastatin, lovastatin, pravastatin, fluvastatin, atorvastatin, cholestyramine, colestipol, imanixil, tetrahydrolipostatin, istmastanylphosphorylcholine, melinamide, nicotinic acid, acipimox, acifran, neomycin, p-aminosalicylic, thyrotropin, polythyroid and dronedarone.