Patent ID: 8226729
Filing Date: 2012-07-24
Classification: A61B,A61F,A61L,A61P

Abstract:
1. A method of generating a bone mass to fuse adjacent vertebrae in a spine of a patient, comprising: preparing a flowable composition for generating said bone mass, said composition including an osteoinductive substance homogeneously entrained within a slow release biodegradable calcium phosphate cement carrier that hardens so as to be impermeable to efflux of the osteoinductive substance in vivo sufficiently that the formed bone mass is confined to the volume of the carrier when implanted, and wherein the carrier gradually exposes the entrained osteoinductive substance at said location as it degrades, and further wherein the osteoinductive substance comprises a bone morphogenic protein present in an amount of from about 2 mg/ml to about 4 mg/ml of the calcium phosphate cement carrier; and introducing said composition in a location between the said vertebrae, wherein said carrier comprises collagen fibers and has a calcium to phosphate ratio of about 0.4 to about 0.6 and the calcium phosphate comprises amorphous calcium phosphate.