Patent ID: 6335326
Filing Date: 2002-01-01
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a salt thereof wherein(R1)n represents 0, 1 or 2 substituents, which substituents can be the same or different, and are chosen from C1-3-alkyl, C1-3 alkoxy, halogen, trifluoromethyl, nitro, amino, monoalkyl-(C1-2)-amino, dialkyl (C1-2)-amino, sulfonyl-(C1-3)alkyl, sulfonyl-(C1-3)alkoxy, sufonyl trifluoromethyl, sulfonyl amino, sulfonyl monoalkyl-(C1-2)-amino and sulfonyl dialkyl (C1-2)-amino groups; X is O, S, NH or NCH3; Y is CH2 or (CH2)2; (R2)m represents 0, 1, or 2 substituents, which substituents can be the same or different, and are chosen from methyl and ethyl groups, or (R2)m is a methylene bridge or ethylene bridge; A is a group â€”CH2â€”(CRH)pâ€” wherein R is hydrogen or methyl and p is 0 or 1; and B is a 2- or 3-indolyl or a 2-benzimidazolyl group, which group may be substituted at each carbon with 1 or 2 substituents chosen from C-1-3-alkyl, C-1-3-alkoxy, halogen, trifluoromethyl, nitro, amino, monoalkyl-(C1-2)amino, dialkyl (C1-2)amino, sulfonyl-(C1-3)alkyl, sulfonyl-(C1-3)alkoxy, sulfonyl trifluoromethyl, sulfonyl amino, sulfonyl monoalkyl-(C1-2)amino and sulfonyl dialkyl (C1-2)-amino groups.