Patent ID: 6420555
Filing Date: 2002-07-16
Classification: C07D

Abstract:
A compound of formula (I), or a pharmaceutically acceptable salt thereof,wherein- - - represents an optional bond; m, n, p, and q are each independently 0 or 1; T for each occurrence is independently selected from the group consisting of CR26R27, S, O, C(O), S(O)2 and NR28; X is Nâ€”Y, O or S where Y is selected from the group consisting of H, CR14R15R16, S(O)R17, S(O)2R18, C(O)R19, C(O)NR20R21, C(S)NR22R23, C(O)OR24, C(S)OR25, S(O)NR29R30 and S(O)2NR31R32; Z is selected from the group consisting of H, cyano, halo, CR14R15R16, S(O)R17, S(O)2R18 and C(O)R19; R1, R2, R3, R4, R5, R6, R11, R12, R13, R14, R15, R16, R26 and R27 are each independently selected from the group consisting of H, halo, hydroxy, thio and cyano, or an optionally substituted moiety selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, arylalkyl, alkyloxy, aryloxy, alkylthio, arylthio, alkylamino, arylamino and alkyl carbonyl amino; or R1 and R2 when on adjacent positions, or R4 and R5, or R11 and R12, are taken together to form a bivalent radical selected from the group consisting of â€”Oâ€”CH2â€”Oâ€”, â€”Oâ€”CH2â€”CH2â€”Oâ€”, â€”Oâ€”CH&boxH;CHâ€”, â€”Oâ€”CH2â€”CH2â€”, â€”Oâ€”CH2â€”CH2â€”CH2â€” and â€”CR33&boxH;CR34â€”CR35&boxH;CR36â€”; R7, R8 and R9 are each independently selected from the group consisting of H, halo, aryl, alkyl, substituted alkyl, alkyloxy, alkylthio, aryloxy, arylthio amino, mono- or di-alkylamino, hydroxycarbonyl, alkoxycarbonyl, alkyl-S(O)-alkyl, alkyl-S(O)2-alkyl, cyanoarylalkyl, arylalkyl and substituted arylakyl; R10 is selected from the group consisting of H, amino, azido, hydroxy, halo, alkyl, substituted alkyl, cyano, hydroxyalkyl, hydroxycarbonyl, aminoalkyl, mono- or di-alkylaminoalkyl, mono- or di-alkylamino, alkoxy, alkylcarbonylalkyl, cyanoalkyl, alkyloxy-carbonylalkyl, carboxyalkyl, cycloalkyl, cycloalkylamino, cycloalkylhydroxy, imidazoyl, substituted imidazoyl, aminocarbonylalkyl, aryloxy, thio, alkylthio, OS(O2)R18, OC(O)R19, OC(O)NR20R21, OC(S)NR22R23, OS(O)NR29R30, OSO)2NR31R32 and arylthio; and R17, R18, R19, R20, R21, R22, R23, R24, R25, R28, R29, R30, R31, R32 and R37 for each occurrence are each independently selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, cycloalkyl, aryl and arylalkyl; or R20 and R21, or R22 and R23, or R29 and R30, or R31 and R32 are taken together to form a bivalent radical selected from the group consisting of â€”(CH2)râ€”NR37â€”(CH2)sâ€”, â€”(CH2)râ€”Oâ€”(CH2)sâ€” and â€”(CR38R39)tâ€”, where r and s are each independently 1 to 3 and t is 2 to 6; R33, R34, R35, R36, R38 and R39 are each independently selected from the group consisting of H, halo, cyano, alkyl, substituted alkyl, aryl, substituted aryl, alkyloxy, aryloxy, alkylthio, arylthio, alkylamino, arylamino, hydroxy and thio.