Patent ID: 6030942
Filing Date: 2000-02-29
Classification: A61K,C12N

Abstract:
A composition comprising an inhibitor of ribonucleotide reductase, wherein the inhibitor has the structure Y.sub.2 -Y.sub.3 -Phe-Y.sub.5 -Asp-Y.sub.6 -Y.sub.4 -OH, whereinY.sub.2 is H or a blocking group;Y.sub.3 is from zero to twenty amino acids;Y.sub.4 is from zero to five amino acids;Y.sub.5 has a structure selected from the group consisting of formula II, wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of amino acid side chain moieties and Z is selected from the group consisting of amide and disulfide bonds, and formula II is ##STR1## and formula III, wherein formula III is ##STR2## and Y.sub.6 is selected from the group consisting of Phe, Tyr, Trp, N-methyl-Phe, D-Phe, o-methyl Phe, m-methyl Phe, o,o-dimethyl Phe, o,m-dimethyl Phe, o-hydroxyl Phe, m-hydroxyl Phe, p-hydroxyl Phe, m-chloro Phe, o-pyridyl Phe, and p-pyridyl Phe.