Patent ID: 6995241
Filing Date: 2006-02-07
Classification: A61P,C07K

Abstract:
1. An isolated human polypeptide selected from the group consisting of: (a) an isolated polypeptide encoded by a polynucleotide comprising of SEQ ID NO: 1; (b) an isolated polypeptide comprising a polypeptide sequence comprising at least 95% identity along its entire length to the polypeptide sequence of SEQ ID NO:2 and which is encoded by a polynucleotide which hybridizes to the complement of SEQ ID NO:1 under stringent hybridization conditions comprising overnight incubation at 42° C. in a solution comprising: 50% formamide, 5×SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5× Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1× SSC at 65° C., wherein said polypeptide has calcium binding activity; c) an isolated polypeptide comprising at least 95% identity along its entire length to the polypeptide sequence of SEQ ID NO:2 and which is encoded by a polynucleotide which hybridizes to the complement of SEQ ID NO:1 under stringent hybridization conditions comprising overnight incubation at 42° C. in a solution comprising: 50% formamide, 5× SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5× Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1× SSC at 65° C., wherein said polypeptide has calcium binding activity; and d) the polypeptide sequence of SEQ ID NO:2.