Patent ID: 7630761
Filing Date: 2009-12-08
Classification: A61K,A61M,A61N

Abstract:
1. A system for delivering electrical stimulation pulses to at least one stimulation site in a body, the system comprising: at least one biologic agent encoding a gene product for modifying tissue to lower a stimulation threshold, the at least one biologic agent including a transcriptional element regulatable by an electric field created by the electrical stimulation pulses delivered to the at least one stimulation site in the body, the transcriptional element operably linked to an open reading frame for the gene product; a reservoir containing the at least one biologic agent; a biologic agent delivery device including the reservoir or coupled to the reservoir, the biologic agent delivery device including at least a portion configured to reach the at least one stimulation site to deliver the at least one biologic agent from the reservoir to the at least one stimulation site; and a biological therapy controller coupled to the biological agent delivery device and adapted to detect evoked potentials in response to the electrical stimulation pulses delivered to the at least one stimulation site and control the delivery of the at least one biologic agent based on whether the evoked potentials are detected.