Patent ID: 9101627
Filing Date: 2015-08-11
Classification: A61K,A61P

Abstract:
1. Pharmaceutical composition for topical administration comprising a mixture of: a) hyaluronic acid or salts thereof selected from the group consisting of sodium and potassium; and b) a bradykinin B2 receptor antagonist together with pharmaceutically acceptable carriers and excipients, wherein: (i) the hyaluronic acid is in polymer form with a mean MW between 0.5 and 10 million daltons, (ii) the hyaluronic acid is in an amount of 1-100 mg per dose, (iii) the bradykinin B2 receptor antagonist is selected from the group consisting of compounds of formula (I) wherein R is hydrogen or methyl W represents a simple bond or an O atom n=3, 4 X is hydrogen or a —NR1R2 amino group in which R1 and R2 can be independently of one another hydrogen or a group selected from methyl, ethyl n-propyl, isopropyl, and Y is a quaternary ammonium (—NR3R4R5) the pharmacologically acceptable salts, enantiomers and enantiomeric mixtures thereof, (iv) the bradykinin B2 receptor antagonist is in an amount of between 5.7×10 −5 and 2.3×10 −2 mMoles per dose, and (v) the composition is in the form of an intra-articular or intrabursal injectable solution or a transdermal form selected from cream, gel or patch.