Patent ID: 8168392
Filing Date: 2012-05-01
Classification: A61K,A61P,C12N,C12Q,G01N

Abstract:
1. A method for identifying a compound that inhibits the cell growth accelerating activity of a tetrahydrofolate synthetase protein, wherein said protein comprises residues 1-978 of SEQ ID NO: 2, or comprises residues 32-978 of SEQ ID NO: 2, wherein said method comprises the steps of comprising: (i) contacting a cell expressing said protein with a test compound under conditions which permit interaction between said protein and said test compound; (ii) culturing said cell and determining the growth rate of said cell during said culturing; and (iii) determining that the test compound inhibits the cell growth accelerating activity of said protein when the growth rate of said cell in the presence of said test compound is reduced in comparison to the growth rate of the cell in the absence of said test compound.