Patent ID: 7153881
Filing Date: 2006-12-26
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method for treatment of conditions associated with melanocortin receptors selected from inflammation, psychoses, depression, anxiety, senile dementia, Alzheimer's disease, anorexia, bulimia, excessive menstruation, endometriosis, events related to parturition, inducing and the prevention of abortion, sexual functions, sexual dysfunctions, drug-induced disorders of the blood and lymphoid system selected from hypersensitivity of the bone marrow and lymphoid tissue, anaemia, granulocytopenia, thrombocytopenia, leukopenia, aplastic anemia, autoimmune hemolytic anaemia, autoimmune thrombocytopenia and autoimmune granulocytopenia, natriuresis, bleeding, shock, ischemia, infarction, reperfusion injuries, arrhythmias of the heart in particular during ischemia, arrhythmias associated with reoxygenation of a previously ischemic heart, pain, inducing skin tanning, inducing lighter skin colour, diabetes mellitus, diabetes type II, obesity, anorexic conditions selected from those caused by cancer, cachexia, geriatric conditions, HIV, trauma and psychological conditions, peripheral nerve regeneration, central nerve regeneration, melanoma, psoriasis, vitiligo, ischemia and ischemia/reperfusion which comprises administering to a patient in need thereof an effective amount of a compound of general formula (I) and its tautomeric form wherein X and Y are independently chosen from O, N, S and (CH Q is H; R wherein R 4 , R 5 , R 6 , and R 7 are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl having 1 to 8 carbon atoms, electron donor groups such as alkoxy having 1 to 5 carbon atoms which with another substituent group may form part of a ring, hydroxy or an amine (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, electron accepting groups such as cyano, nitro, trifluoroalkyl, amide or sulpho, or be selected from; wherein R 8 , R 9 and R 10 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 8 carbon atoms, electron donor groups such as alkoxy having 1 to 5 carbon atoms, which with another substituent group may form part of a ring, hydroxy or an amine (primary, secondary, tertiary) having 0, 1 or 2 carbon atoms, electron accepting groups such as cyano, nitro, triflyoralkyl, amide or sulpho; with the proviso that where X is (CH 2 ) n and n is O 1 , R 2 is not H; or a pharmacologically active salt thereof.