Patent ID: 8993766
Filing Date: 2015-03-31
Classification: A61P,C07D,C07F

Abstract:
1. A method for preparing tetrabenazine, comprising: a process of subjecting a compound represented by the following Formula 3 and a compound represented by the following Formula 4 to an alkylation reaction to prepare a compound represented by the following Formula 5; a process of subjecting the compound represented by the following Formula 5 to an Aza-Prins cyclization reaction in the presence of an oxidant to prepare a ring compound represented by the following Formula 6; and a process of subjecting the ring compound represented by the following Formula 6 to an oxidation reaction, such that a methylene group of the ring compound is converted into a keto group, to prepare tetrabenazine represented by the following Formula 1: in the Reaction Scheme, X is a leaving group and represents a halogen element, a methanesulfonyloxy group or a p-toluenesulfonyloxy group.