Patent ID: 6057477
Filing Date: 2000-05-02
Classification: C07C,C07D

Abstract:
A process for the preparation of an .alpha.-chloroketone compound of formula (I) comprising the steps of(i) cyclizing an alkynyl amide of formula (II), optionally in the presence of an organic solvent, using a catalytic quantity of a metal salt to form a 5-methyleneoxazoline of formula (III) ##STR14## (ii) chlorinating the 5-methyleneoxazoline of formula (III) in a solvent using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate of formula (IV) ##STR15## and (iii) hydrolyzing the chlorinated oxazoline intermediate of formula (IV) with an aqueous acid to produce the desired monochloroketone of formula (I) ##STR16## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.