Patent ID: 7348338
Filing Date: 2008-03-25
Classification: A61K,A61P,C04B,C07D

Abstract:
1. A method for treating a patient suffering from or at risk of a disease or condition for which PPAR modulation provides a therapeutic benefit, comprising administering to said patient a PPAR modulator having the chemical structure of Formula wherein U, V, W, X, and Y are independently CR R R R R R R R R R Z is O or S; and n=1; or a pharmaceutically acceptable salt thereof, wherein said compound is different from 3-(5-methoxy-1-p-toluenesulfonylindol-3-yl)propionic acid and 1-(2,4,6-triisopropylphenylsulfonyl)indole-3-propionic acid, and wherein the disease or condition is selected from the group consisting of obesity, hyperlipedemia, associated diabetic dyslipidemia, mixed dyslipidemia, hypertriglyceridemia, hypoalphalipoproteinemia, Syndrome X, Type II diabetes mellitus, Type I diabetes, hyperinsulinemia, impaired glucose tolerance insulin resisstance, a diabetic complication of neuropathy, neuropathy, retinopathy or cataracts, cardiovascular disease selected from the group consisting of hypertension, coronary artery disease, heart failure, congestive heart failure, atherosclerosis, and atherosclerosis; eczema, psoriasis, colitis, and regulation of appetite and food intake.