Patent ID: 7846475
Filing Date: 2010-12-07
Classification: A61K

Abstract:
1. A soft capsule comprising a capsule shell having a water content (S) and a capsule filling having a water content (C) which is a crude drug extract in aqueous solution, an animal extract in the form of an aqueous solution or a plant extract in the form of an aqueous solution, wherein a solution for the capsule shell comprises a shell material and a humectant or water activity lowering agent, wherein the shell material comprises gelatin, a gelatin derivative, a polysaccharide, a cellulose, or a synthetic polymer, wherein said gelatin derivative is at least one selected from the group consisting of succinated gelatin, hydrolyzed gelatin, and cross-linked gelatin, a ratio of the shell material to the humectant or the water lowering agent ranges from 1:2 to 3:1, a water activity of the capsule filling is 0.5≦a≦1 and a water activity of the capsule shell is 0.25≦a≦0.9, and the capsule shell after drying said capsule has the water activity lower than that of the capsule filling, and a ratio of the water content (C) of the capsule filling to the water content (S) of the capsule shell is 0.7≦C/S≦15.