Patent ID: 6448278
Filing Date: 2002-09-10
Classification: A61K,C07C,C07D,C07F,C07K

Abstract:
A compound of formula (I): wherein:X is C1-6 alkylene or C2-6 alkenylene, each of which is optionally substituted by one or more fluorine atoms; R is aryl or C3-8 cycloalkyl optionally substituted by one or more fluorine atoms; W is N or CZ; Y and Z are each independently H, C1-4 alkyl wherein said C1-4 alkyl is optionally substituted by one or more substituents independently selected from halogen, S(O)pR6, OR5, CONR1R2, CO2R7 and aryl, C1-4 alkanoyl optionally substituted by one or more halogen, C1-4 alkoxycarbonyl optionally substituted by one or more halogen, or CONR1R2; R1 and R2 are each independently selected from H, C3-8 cycloalkyl, C1-4 alkyl wherein said C1-4 alkyl is optionally substituted by C3-8 cycloalkyl, aryl, CO2H, CO2R5 or NR3R4, or R1 and R2 when taken together with the nitrogen to which they are attached represent a 4- to 6-membered heterocyclic ring optionally containing one or two further hetero atoms in the ring independently selected from N, O and S, which heterocyclic ring is optionally benzo- or pyrido-fused, and which heterocyclic ring is optionally substituted by C1-4 alkyl, CO2H, CO2R5, aryl or NR3R4; R3 and R4 are each independently selected from H, C1-C4 alkyl or C1-4 alkoxycarbonyl optionally substituted by one or more halogen, or R3 and R4 when taken together with the nitrogen atom to which they are attached represent a morpholine, piperidine, azetidine or piperazine wherein each of said morpholine, piperidine, azetidine or piperazine is optionally N-substituted by C1-4 alkyl moiety; R5 is C1-4 alkyl optionally substituted by CO2R7 or CONR3R4, or R5 is aryl; R6 is C1-4 alkyl optionally substituted by one or more halogen, or aryl; R7 is H or R6; p is 0, 1 or 2; â€œArylâ€  is a mono- or bicyclic aromatic carbocyclic or heterocyclic ring system having from 5 to 10 ring atoms, containing up to 3 hetero-atoms selected from N, O and S, wherein said N hetero-atoms can be optionally substituted by an oxide, which ring system is optionally substituted by up to 3 substituents independently selected from halogen, C1-4 alkyl optionally substituted by one or more halogen, C1-4 alkoxy optionally substituted by one or more halogen, phenyl, pyridyl, CO2H, CONR3R4, CO2(C1-4 alkyl), NR3R4, OH and OC(O)(C1-4 alkyl); and the pharmaceutically acceptable salts, solvates or prodrugs thereof.