Patent ID: 8637244
Filing Date: 2014-01-28
Classification: C12Q,G16B

Abstract:
1. A method of determining a susceptibility to atrial fibrillation, atrial flutter, or stroke in a human individual, the method comprising: analyzing a nucleic acid sample from the individual to determine the presence or absence of at least one polymorphic marker allele selected from allele T of polymorphic marker rs2220427, allele T of polymorphic marker rs2200733, and allele T of polymorphic marker rs10033464, and detecting the presence of at least one of the polymorphic marker alleles in the nucleic acid sample, and determining susceptibility to atrial fibrillation, atrial flutter or stroke in the human individual by calculating a risk score for the human individual that includes a relative risk (RR) or an odds ratio (OR) of at least 1.3 attributed to the presence of the at least one polymorphic marker allele in the nucleic acid sample from the individual, wherein the determining is performed using an apparatus comprising: a computer readable memory; a processor; and a routine stored on the computer readable memory; wherein the routine is adapted to be executed on the processor to analyze genotype data with respect to the at least one polymorphic marker and generate an output based on the genotype data, wherein the output comprises a risk score for the human individual with respect to susceptibility to atrial fibrillation, atrial flutter, or stroke.