Patent ID: 6265609
Filing Date: 2001-07-24
Classification: C07C

Abstract:
A compound of formula I ##STR88##or a pharmaceutically acceptable salt, hydrate, metabolite, or prodrug thereof, wherein:X is a moiety of formula II ##STR89##n is 1, 2, 3 or 4;Y is SR.sub.5 ;A is CH.sub.2 ;R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are indepencicntly hydrogen, C.sub.1 -C.sub.9, straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, Ar.sub.1, hydroxy, carboxy, (arbonyl, amino, amido, cyano, isocyano, nitro, sulfonyl, sulfoxy, thio, thiocarbonyl, thiocyano, formanilido, thioformamido, sulfhydryl, halo, haloalkyl, trifluoromethyl, or oxy, wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl and Ar.sub.1, are independently unsubstituted or substituted with one or more substituent(s);R.sub.1 is (CH.sub.2).sub.2 COOR or (CH.sub.2).sub.2 CONHR; andAr.sub.1 is a carbocyclic or heterocyclic moiety, which is unsubstituted or substituted with one or more substituent(s).