Patent ID: 8957233
Filing Date: 2015-02-17
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
1. A method for preparing an optically active 1,2-bis(dialkylphosphino)benzene derivative represented by the following general formula (A), characterized in that a phosphine-borane compound represented by the following general formula (1) is subjected to deboronation reaction, followed by lithiation, then the reaction product is subjected to reaction with an alkyldihalogenophosphine represented by R a PX′ 2 (where, R a is either R 1 or R 2 defined in formula (A), and X′ represents a halogen atom) and thereafter the reaction product is subjected to reaction with a Grignard reagent represented by the general formula R b MgX″ (where, R b is either R 1 or R 2 as defined in formula (A), provided that R a and R b are not the same, and X″ represents a halogen atom) to produce an optically active 1,2-bis(dialkylphosphino)benzene derivative (where R (where R