Patent ID: 6337091
Filing Date: 2002-01-08
Classification: A61K

Abstract:
A simple compressed matrix tablet suitable for manufacture on high speed tableting machines which provides sustained delivery of soluble pharmaceutical agents comprising:(a) a singular polymer matrix of a polymer which is swellable and erodible, and (b) a plurality of granules embedded within and dispersed throughout said polymer matrix, said granules comprising: (i) a polymer which is swellable; and (ii) a pharmaceutically effective amount of a soluble pharmaceutical agent incorporated in the polymer (i) of said granules, wherein the polymer of the matrix (a) is more swellable and erodible than the polymer (i) of said granules and wherein the polymer matrix has diffusion rate coefficient greater than the diffusion rate coefficient of said granules, the polymer of the matrix (a) is selected from the group consisting of HPMC, polyethylene oxide, and a mixture of HPMC and pectin, and the polymer (i) of the granule is selected from the group consisting of gelatin, gum tragacanth, and pectin.