Patent ID: 7087378
Filing Date: 2006-08-08
Classification: A61F,A61K,A61P,C07D,C07K,C08G,C12Q

Abstract:
1. A method for designing a specific polyamide wherein X γ is γ-aminobutyric acid or 2,4 diaminobutyric acid, and R (a) identifying a target sequence of double stranded DNA having the form 5′-WN (b) representing the identified sequence as 5′-Wab . . . xW-3′, wherein a is a first nucleotide to be bound by the X (c) defining a as A, G, C, or T to correspond to the first nucleotide to be bound by a carboxamide residue in the identified sequence; (d) selecting Im as the X (e) selecting Py as the X (f) selecting Hp as the X (g) selecting Py as the X (h) repeating steps c–g for b through x until all carboxamide residues are selected; wherein Im is N-methylimidazole, Hp is 3-hydroxy-N-methylpyrrole, Py is N-methylpyrrole, A is adenine, G is guanine, C is cytosine, and T is thymine; and synthesizing the polyamide.