Patent ID: 7914818
Filing Date: 2011-03-29
Classification: A61K,A61P

Abstract:
1. An oral dosage form comprising (i) a therapeutically effective amount of an opioid agonist; (ii) naloxone or a pharmaceutically acceptable salt thereof in releasable form; and (iii) sequestered naltrexone or a pharmaceutically acceptable salt thereof which is not substantially released when the dosage form is administered intact, but which is released in an amount sufficient to reduce or eliminate an analgesic or euphoric effect of the opioid when administered after the integrity of the dosage form has been compromised; and (iv) a sustained release excipient; wherein the opioid agonist, naloxone and the sequestered naltrexone are interdispersed in the sustained release excipient, and the sustained release excipient provides a sustained release of the opioid agonist and naloxone, and the sequestered naltrexone is in the form of inert beads coated with naltrexone and overcoated with a sequestering material.