Patent ID: 6770444
Filing Date: 2004-08-03
Classification: A61K,C07K,C12N

Abstract:
A process for determining whether a chemical compound specifically binds to:(a) a soluble polypeptide comprising consecutive amino acids, the amino acid sequence of which is shown in FIG. 5 (SEQ ID NO: 10); or (b) a soluble polypeptide having a sequence which varies therefrom by no more than 15 amino acids, such variations: (i) not involving amino acids corresponding to the amino acids at positions 799-804 of the amino acid sequence shown in FIG. 5 (SEQ ID NO: 10); and (ii) not changing the functional properties of the soluble polypeptide; or (c) a soluble polypeptide comprising the soluble polypeptide of (a) or (b) linked to the following consecutive amino acids: Asp Tyr Lys Asp Asp Asp Asp Lys, which comprises contacting the soluble polypeptide of (a), (b) or (c) above with the compound under conditions suitable for binding, and detecting specific binding of the chemical compound to the soluble polypeptide.