Patent ID: 7994328
Filing Date: 2011-08-09
Classification: C07D

Abstract:
1. An improved process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride of Formula I which comprises, (i) reacting 5,6-dimethoxy-1-indanone (II), with 1-benzyl-4-piperidinecarboxaldehyde (III), in presence of base and an antioxidant to produce 1-benzyl-4-[5,6-dimethoxy-1-indanon)-2-ylidenyl]methyl]piperidine toluene solvate, (ii) hydrogenating 1-benzyl-4-[5,6-dimethoxy-1-indanon)-2-ylidenyl]methyl]piperidine toluene solvate with a metal catalyst in a solvent or mixture of solvents followed by treating the resulting compound with hydrochloric acid to produce 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride of Formula I.