Patent ID: 6372725
Filing Date: 2002-04-16
Classification: C07H

Abstract:
A compound of formula I whereinR1 is a straight-chained or branched, saturated or unsaturated alkyl group containing 9-14 carbon atoms; R2 is a straight-chained or branched, saturated or unsaturated alkyl group containing 8-12 carbon atoms; m is 2; n is 0-2; A is oxygen; and Nuc is a coupled nucleoside residue selected from the group consisting of 2â€²,3â€²-dideoxy-3â€²-azidouridine, 2â€²,3â€²-dideoxyinosine, 2â€²,3â€²-dideoxyguanosine, 2â€²,3â€²-dideoxycytidine, 2,3â€²-dideoxyadenosine, 2,3â€²-deoxthymidine, 2,3â€²-dideoxy-2â€²-3â€²-didehydro-N6-(o-methylbenzyl)-adenosine, 2â€²,3â€²-dideoxy-2â€²-3â€²-didehydro-N6-(2-methylpropyl)-adenosine, 2â€²,3â€²-dideoxy-3â€²-azidoguanosine, 3â€²-deoxy-3â€²-azido-thymidine, 2â€²,3â€²-dideoxy-3â€²-fluoro-5-chlorouridine, 3â€²-deoxy-3â€²-fluorothymidine, 2â€²,3â€²-dideoxy-3â€²-fluoroadenosine, 2â€²,3â€²-dideoxy-3â€²-fluoro-2,6-diaminopurine-riboside, 2â€²,3â€²-dideoxy-2â€²-3â€²-didehydrocytidine, 3â€²-deoxy-2â€²-3â€²-didehydrothymidine, 5-fluorouridine, 6-mercaptopurine-9-&bgr;-D-ribofuranoside, Acyclovir, Ganciclovir, adenine-9-&bgr;-D-arabinofuranoside, 2-chloro-2â€²-deoxyadenosine, 3-(2-deoxy-&bgr;-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol, cytosine-9-&bgr;-D-arabinofuranoside, guanine-9-&bgr;-D-arabinofuranoside, hypoxanthine-9-&bgr;-D-arabinofuranoside, 2â€²-deoxy-2-fluoroadenosine 2-fluoroadenine-9-&bgr;-D-arabinofuranoside, 2-fluoroadenosine, 2-amino-6-mercaptopurine-9-&bgr;-D-ribofuranoside, 6-methylmercaptopurine-9-&bgr;-D-ribofuranoside, 3â€²-deoxy-5-fluorouridine, 2-chloroadenosine, 3â€²-deoxy-3â€²-fluoroadenosine, 3â€²-deoxy-3â€²-fluoroguanosine, 1-(&bgr;-D-arabinofuranosyl)-5-ethinyluracil, 1-(&bgr;-D-arabinofuranosyl)-5-prop-1-inyluracil, and 1-(&bgr;-D-arabinofuranosyl)-5-prop-2-inyluracil, wherein the Nuc moiety is coupled to the moiety A via the 5â€²-O- position of the sugar residue.