Patent ID: 8323630
Filing Date: 2012-12-04
Classification: A61K,A61P,Y02A

Abstract:
1. A multi-dose, self-preserved ophthalmic solution, comprising: a therapeutically effective amount of an ophthalmically acceptable therapeutic agent; zinc ions at a concentration of 0.1 to 0.4 mM; borate at a concentration of 0.5 to 1.2% w/v; propylene glycol at a concentration of 0.25 to 1.25%; and sorbitol at a concentration of 0.05 to 0.5% w/v; wherein: (i) the concentration of anionic species in the solution is less than 15 mM; (ii) the concentration of multivalent buffering anions in the solution is less than 5 mM; (iii) the concentration of multivalent metal cations other than zinc in the solution is less than 5 mM; and (iv) the solution exhibits sufficient antimicrobial activity to allow the solution to satisfy USP 27 preservative efficacy requirements.