Patent ID: 8357386
Filing Date: 2013-01-22
Classification: A61K,A61L

Abstract:
1. A drug coating, comprising: a uniform dispersion of one or more anti-restenotic agents and one or more hydrophobically-modified bioactive binders, wherein the hydrophobically-modified bioactive binders are the only binders in the uniform dispersion, and the hydrophobically-modified bioactive binders are water insoluble and act as a carrier for the anti-restenotic agents, the hydrophobically-modified bioactive binders including a positively-charged amine compound ionically-bonded to a glycosaminoglycan, wherein the anti-restenotic agents are elutable from the drug coating and the glycosaminoglycan is elutable from the drug coating, and wherein the positively-charged amine compound is a tertiary amine, quaternary amine, polylysine, protamine sulfate, hexadimethrine bromide, polyethylene imine, or polyhexamethylene biguanide.