Patent ID: 6734183
Filing Date: 2004-05-11
Classification: A61P,C07D

Abstract:
A compound of the formula I, or a pharmaceutically acceptable salt, or an in vivo hydrolysable ester thereof, whereinB is a 2-pyridyl or 2-pyridyloxy group monosubstituted at the 4-, 5-, or 6-position by trifluoromethyl; X is a nitrogen atom; R1 is a trimethyl-1-hydantoin C2-4alkyl or a trimethyl-3-hydantoin C2-4alkyl group; or R1 is phenyl or C2-4alkylphenyl monosubstituted at the 3- or 4-position by halogen, trifluoromethyl, thio, C1-3alkyl, or C1-3alkoxy; or R1 is phenyl-SO2NHC2-4alkyl; or R1 is 2-pyridyl or 2-pyridyl C2-4alkyl; or R1 is 3-pyridyl or 3-pyridyl C2-4alkyl; or R1 is 2-pyrimidine-SCH2CH2; or R1 is 2- or 4-pyrimidinyl C2-4alkyl optionally monosubstituted by one of halogen, trifluoromethyl, C1-3alkyl, C1-3alkyloxy; 2-pyrazinyl optionally substituted by halogen, or 2-pyrazinyl C2-4alkyl optionally substituted by halogen.