Patent ID: 7550490
Filing Date: 2009-06-23
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula I: or its stereoisomer, enantiomer, diastereomer or a pharmaceutically acceptable salt thereof, wherein: A is a phenyl or pyridyl, optionally substituted with 1 to 4 substituents selected from the group consisting of a halogen atom, an amino group, a nitro group, an alkyl group having 1 to 4 carbons, an alkoxy group having 1 to 4 carbons, an alkyl-amino having 1 to 4 carbons, and a perfluoroalkyl group having 1 to 4 carbons; B is a phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, an alkyl group having 1 to 4 carbons, an alkoxy group having 1 to 4 carbons, an aminoalkyl group having 1 to 4 carbons, an alkylamino group having 1 to 4 carbons, an acyl group having 2 to 4 carbons, an acylamino group having 2 to 4 carbons, an alkylthio group having 1 to 4 carbons, a perfluoroalkyl group having 1 to 4 carbons, a perfluoroalkyloxy group having 1 to 4 carbons, a carboxyl group, an alkoxycarbonyl group having 1 to 4 carbons, and a phenyl group; Z is a bond; Y is a moiety having —CO— which is linear and in which the distances between the centroid of ring B (W1), the centroid of ring A (W2) and an oxygen atom as a hydrogen bond acceptor in the moiety Y (W3) are: W1−W2=about 6.0 to about 12.0 Å, W1−W3=about 3.0 to about 6.0 Å, and W2−W3=about 4.0 to about 8.0 Å, respectively; R R R one of X provided, however, that: when R when R