Patent ID: 6228346
Filing Date: 2001-05-08
Classification: A61K

Abstract:
A propellant mixture for pharmaceutical aerosols for micronizing the pharmaceuticals for pulmonary application, whereinsaid propellant mixture exists in a subcritical state and includes at least one component from a first class of propellant gases and at least one component from a second class of propellant gases,said first class comprising propellant gases having an evaporation enthalpy at 25.degree. C. of 200 kJ/kg or less and a vapor pressure at 25.degree. C. of 20 bar or more, andsaid second class comprising propellant gases having an evaporation enthalpy at 25.degree. C. of 300 kJ/kg or more and a vapor pressure at 25.degree. C. of 10 bar or less,wherein at least about 80 wt. % of the micronized pharmaceuticals have a diameter of less than 8 .mu.m.