Patent ID: 8691782
Filing Date: 2014-04-08
Classification: A61K,A61P,C07F,C12N

Abstract:
1. A single-stranded nucleic acid molecule comprising: an expression inhibitory sequence that inhibits expression of a target gene, wherein the single-stranded nucleic acid molecule comprises: a region (X); a linker region (Lx); a region (Xc), a region (Y); a region (Yc); and a linker region (Ly) linked between the region (Y) and the region (Yc), the 5′ end and the 3′ end of the single-stranded nucleic acid molecule are not linked to each other, the linker region (Lx) is linked between the regions (X) and (Xc), the region (X) and the region (Y) are linked to each other, an inner region (Z) consists of the region (X) and the region (Y), and has 19 to 30 bases, the region (Xc) is complementary to the region (X), and has 1 to 29 bases, the region (Yc) is complementary to the region (Y), and has 1 to 29 bases, the inner region (Z) comprises the expression inhibitory sequence, the expression inhibitory sequence is a ribonucleic acid (RNA) molecule, and the linker region (Lx) comprises a non-nucleotide structure comprising at least one of a pyrrolidine skeleton and a piperidine skeleton.