Patent ID: 6277283
Filing Date: 2001-08-21
Classification: B01D,F16K,G01N

Abstract:
A chromatography process carried out in chromatography apparatus comprising a column housing with a housing wall defining an enclosed bed space, a valve communicating with the bed space through the housing wall, and first and second fluid flow conduits each having a respective exterior connection outside the column housing and a respective interior opening to the bed space through the valve;said process comprising:adjusting the valve to open the first conduit to the bed space;a packing step of supplying a dispersion of packing material particles in a carrier liquid along said first fluid flow conduit and into the bed space through the valve, forming a bed of said packing material particles in the bed space;adjusting said valve to close off both the first and second fluid flow conduits from the bed space and to put the first and second fluid flow conduits into fluid communication with one another in the valve to form a continuous flow path isolated from the bed space, anda cleaning step comprising passing fluid along the continuous flow path formed by the first and second fluid flow conduits.