Patent ID: 8828969
Filing Date: 2014-09-09
Classification: A61K,A61P

Abstract:
1. A method for relieving pain in a joint disease, comprising: administering to a human subject in need thereof a pharmaceutical composition comprising hyaluronic acid that is cross-linked by cyclizing a double bond in a moiety of a cinnamic acid in a partially amidated hyaluronic acid represented by Formula (1), to form a cyclobutane ring, in which Ar represents an optionally substituted phenyl group, n represents an integer of 2 or 3, HA represents a carboxy residue of the hyaluronic acid, and m represents an amidation ratio of the hyaluronic acid to a total of a carboxyl group and is 3% to 50% relative to the total carboxyl group; and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is an injection product, wherein the cross-linked hyaluronic acid is 1% by weight per volume of the injection product, wherein a single dosage of the injection product is 2 to 3 mL, and wherein the pharmaceutical composition is a single-dose preparation that is administered at an interval of 13 weeks or more.