Patent ID: 8946182
Filing Date: 2015-02-03
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method of increasing the expression of an RNase H1 polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 15 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of the RNase H1 gene and has at least 90% sequence identity to a reverse complement of a polynucleotide comprising 15 to 30 consecutive nucleotides within nucleotides 1 to 437 of SEQ ID NO: 2 or nucleotides 1 to 278 of SEQ ID NO: 3 or nucleotides 1 to 436 of SEQ ID NO: 4 or nucleotides 1 to 1140 of SEQ ID NO: 5: thereby increasing the expression of the RNase H1 polynucleotide in patient cells or tissues in vivo or in vitro and used in conjunction with antisense oligonucleotides targeted against other targets to increase their activity.