Patent ID: 7087711
Filing Date: 2006-08-08
Classification: C07K,C12N

Abstract:
1. A transcriptional activator comprising: a DNA binding moiety; and a transcription activation peptide that is at least approximately 25% hydrophobic and wherein the peptide is 6, 8, 11, or 13 amino acids in length, which peptide is linked to the DNA binding moiety in a manner that does not interfere with its DNA binding activity, the transcription activation peptide being both necessary and sufficient to activate transcription, the transcriptional activator being characterized by an ability, when expressed in yeast cells, to activate transcription from a promoter including a recognition site for the DNA binding moiety approximately 250–1000 basepairs upstream of the transcription start site, the transcriptional activator being characterized by an inability to squelch transcriptional activation by LexA-Gal4 when expressed in yeast.