Patent ID: 8404891
Filing Date: 2013-03-26
Classification: A61K,A61P

Abstract:
1. A method for the production of a liquid formulation of paracetamol that is stable to oxidation in an aqueous solvent, comprising the following steps in order: i) dissolving paracetamol in an aqueous solvent having a temperature between 65° C. and 95° C., and having pH between 5.0 and 6.0 in a reaction vessel, ii) optionally, replacing the remaining air in the vessel by an inert gas, iii) cooling the solution so formed to a temperature equal to or above 35° C. and below 40° C., iv) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring, and v) closing the reaction vessel and stirring the solution of step iv).