Patent ID: 6783933
Filing Date: 2004-08-31
Classification: C07K,C12Q

Abstract:
A method for detecting colorectal adenoma or a cancer other than glioma, comprising:a) contacting a nucleic acid-containing specimen from a subject with an agent that provides a determination of the methylation state of at least one of a first region and a second region of a CpG island of CACNA1G, wherein the first region is a region of the CACNA1G CpG island that is amplified by SEQ ID NO:33 and SEQ ID NO:34, and wherein the second region is a region of the CACNA1G CpG island that is amplified by SEQ ID NO:35 and SEQ ID NO:36, and b) detecting hypermethylation of at least one of the first region and the second region, wherein hypermethylation of at least one of the first region and the second region as compared to the same region of the CACNA1G gene in a subject not having colorectal adenoma or a cancer other than glioma is indicative of the colorectal adenoma or cancer other than glioma.