Patent ID: 8808687
Filing Date: 2014-08-19
Classification: A61K,A61L,A61P,C12N,Y10T

Abstract:
1. A substrate for cellular therapy to treat diseased or damaged ocular tissue, comprising: a solid planar parylene substrate configured for implantation into a human eye, the substrate comprising a long axis and a short axis; and a distinct parylene apical surface for the growth of a population of human embryonic stem cell-derived RPE cells, and a distinct parylene basal surface; wherein the apical surface has a thickness ranging from about 0.1 to about 5 microns allowing passage of molecules having a molecular weight of up to about 75 kilodaltons and has an integrally formed continuous raised lip positioned around the perimeter to reduce migration of human stem cell-derived RPE cells off the apical surface; and wherein the basal surface comprises a plurality of supporting protrusions, the supporting protrusions being periodic, columnar in shape, and running longitudinally along the length of the long axis of the basal surface of the substrate and the basal surface is configured to prevent the growth of blood vessels through said basal surface to said apical surface.