Patent ID: 6509147
Filing Date: 2003-01-21
Classification: A61K,A61M,A61P

Abstract:
A method for increasing and/or decreasing the concentrations of immunomodulatory effective substances in blood plasma, the method comprising the steps of:separating blood into corpuscular components and blood plasma or blood plasma components; adding the blood plasma to a bioreactor containing immunomodulatory cells; contacting the blood plasma in the bioreactor with the immunomodulatory cells, wherein the cells have specific surface receptors and are able to decrease the concentrations of immunomodulatory effective substances in the plasma by adsorption of such substances at the specific receptors, and the cells are able to increase the concentrations of immunomodulatory effective substances in the plasma by releasing immunomodulatory effective substances into the plasma, separating the plasma from the immunomodulatory cells and removing it from the bioreactor, wherein the immunomodulatory cells are selected from the group consisting of endothelial cells, leukocytes, cells obtained from haematopoietic stem cells through differentiation, and cell lines derived from the aforementioned cells, and wherein the immunomodulatory effective substances belong to the group consisting of growth factors, endotoxines, and cytokines.