Patent ID: 7776838
Filing Date: 2010-08-17
Classification: A61K,C07H

Abstract:
1. A method for treating toxicity due to a pyrimidine nucleoside analog in an animal comprising administering to said animal a pharmaceutically effective amount of an acylated derivative of uridine or cytidine selected from the group consisting of triacetyluridine and ethoxycarbonyluridine or triacetylcytidine, wherein said pyrimidine nucleoside analog is selected from the group consisting of 5-fluorouracil (5-FU), Tegafur, 5-fluoroorotate, 5′-deoxy-5-fluorouridine, 5-fluorouridine, 2′-deoxy-5-fluorouridine, fluorocytosine, trifluoromethyl-2′-deoxyuridine, arabinosyl cytosine, cyclocytidine, 5-aza-2′-deoxycytidine, arabinosyl 5-azacytosine, 6-azacytidine, N-phosphonoacetyl-L-aspartic acid (PALA), pyrazofurin, 6-azauridine, azaribine, thymidine, 3-deazauridine, AZT, dideoxycytidine, 5-ethyl-2′-deoxyuridine, 5-iodo-2′deoxyuridine, 5-bromo-2′-deoxyuridine, 5-methylamino-2′-deoxyuridine, arabinosyluracil, dideoxyuridine and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine; and wherein said toxicity is selected from the group consisting of damage to hematopoietic tissue and damage to mucosal tissues.