Patent ID: 6384201
Filing Date: 2002-05-07
Classification: C07H

Abstract:
A method for making etoposide, comprising the steps of:condensing 4â€²-demethyl-epipodophyllotoxin of formula (2) with a glucopyranose of formula (13) in an organic solvent at a temperature below âˆ’30Â° C. and in the presence of trimethylsilyl triflate catalyst (TMSOTf), to give a compound of formula (14): â€ƒwhere R1 is â€”COCH3, â€”COCH2X, â€”COCHX2, or â€”COCX3, and each occurrence of X is independently selected from a halogen; and converting compound (14) to etoposide having the following formula (1):