Patent ID: 6528649
Filing Date: 2003-03-04
Classification: A61P,C07D

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein:n is 1, 2, 3, or 4, R1, R2, and R3 are the same or different and represent: i) hydrogen, halogen, hydroxy, ii) Ra wherein Ra is â€”O(C1-8 alkyl) , â€”NO2, â€”CN, â€”SO2NH2, â€”SO2NH(C1-8 alkyl), â€”SO2N(C1-8 alkyl) (C1-8 alkyl), amino, â€”NH(C1-8 alkyl) , â€”N(C1-8 alkyl) (C1-8 alkyl), â€”NHCO(C1-8 alkyl, â€”N(C1-8 alkyl)CO(C1-8 alkyl), â€”NHCO2(C1-8 alkyl) â€”N(C1-8 alkyl)CO2(C1-8 alkyl), â€”NHSO2(C1-8 alkyl), â€”CONH2, â€”CONH(C1-8 alkyl), â€”CON(C1-8 alkyl) (C1-8 alkyl), â€”CO2(C1-8 alkyl) , â€”S(C1-8 alkyl) , â€”SO (C1-8 alkyl) , or â€”SO2(C1-8 alkyl), wherein each C1-8 alkyl independently is straight, branched or cyclic, contains zero, one or two double or triple bonds, and is optionally substituted with one or more of hydroxy, oxo, halogen, amino, or C1-8 alkoxy, or Ra is C1-8 alkyl, which is straight, branched or cyclic, contains zero, one or two double or triple bonds, and is unsubstituted or substituted with one or more of a) hydroxy, b) oxo, c) halogen, e) â€”O(C1-8 alkyl), f) â€”NR4R5 wherein R4 and R5 are independently selected from hydrogen and C1-8 alkyl, or R4 and R5 may be joined together to form a monocyclic or bicyclic ring, each of which may contain one or more double bonds, or where one or more of the ring members is carbonyl, O, S, SO, SO2 or Nâ€”R6, wherein R6 is hydrogen, C1-6 alkyl, C1-6 alkyl-Ar2, wherein Ar2 is attached to C1-6 alkyl at any position and is optionally substituted with one or two groups, Rb and Rc, wherein Rb and Rc independently carry the definition of Ra , or g) â€”CONR7R8, or â€”CO2R7 wherein each R7 and R8 is independently hydrogen or C1-6 alkyl, iii) Ar1, wherein Ar1 is phenyl, pyridyl, pyrazlnyl, pyrimidinyl, imidazolyl, furanyl, thiazolyl, isothiazolyl, isoxazolyl, oxadiazolyl, triazolyl, tetrazolyl, or pyrazolyl, each of which is unsubstituted or substituted with hydrogen, halogen, hydroxy, C1-8 alkyl, â€”O(C1-8 alkyl), â€”NO2, â€”CN, â€”SO2NH2, â€”SO2NH(C1-8 alkyl) , â€”SO2N(C1-8 alkyl) (C1-8 alkyl) amino, â€”NH(C1-8 alkyl) , â€”N(C1-8 alkyl) (C1-8 alkyl) , â€”NHCO(C1-8 alkyl) , â€”N(C1-8 alkyl) CO(C1-8 alkyl) , â€”NHCO2(C1-8 alkyl) , â€”N(C1-8 alkyl)CO2(C1-8 alkyl) , â€”NHSO2(C1-8 alkyl) , â€”CONH2, â€”CONH(C1-8 alkyl) , â€”CON(C1-8 alkyl) (C1-8 alkyl) , â€”CO2(C1-8 alkyl) , â€”S(C1-8 alkyl), â€”SO(C1-8 alkyl), or â€”SO2(C1-8 alkyl), â€”CON7R8, or â€”CO2R7 (wherein each R7 and R8 is independently hydrogen or C1-C6 alkyl) wherein each C1-8 alkyl independently is straight, branched or cyclic, contains zero, one or two double or triple bonds, and is optionally substituted with one or more of hydroxy, oxo, halogen, amino, or C1-8 alkoxy; X is CH, or CRd, wherein Rd carries the same definition as Ra; W is phenyl, unsubstituted or substituted with one or more of hydrogen, halogen, hydroxy, alkoxy, Rx where Rx carries the same definition as Ra, or Ar3 wherein Ar3 carries the same definition as Ar1; and Q is phenyl, thienyl, benzothienyl, pyridyl, isoquinolyl, quinolyl, pyrazinyl, pyrimidinyl, imidazolyl, benzoimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isoxazolyl, oxadiazolyl, isothiazolyl, benzisothiazolyl, triazolyl, tetrazolyl, pyrrolyl, indolyl, pyrazolyl, benzopyrazolyl, each of which is unsubstituted or substituted with one or more of: hydrogen, halogen, hydroxy, alkoxy, Ry where Ry carries the same definition as Ra, or Ar4 wherein Ar4 carries the same definition as Ar1.