Patent ID: 6444709
Filing Date: 2002-09-03
Classification: A61P,C07C,Y10S

Abstract:
Heteroethynylenic compounds, corresponding to formula (I) below: in which:R1 represents: (i) a â€”CH3 radical (ii) a radical â€”CH2â€”Oâ€”R5 (iii) radical â€”COR6 â€ƒR5 and R6 having the meanings given below, X represents: O, Se, S(O)n, n being 0, 1 or 2, Y represents a divalent radical which has the formula: â€ƒR7, R8, R9 and R10 having the meanings given below, R2 and R3, taken together, form, with the adjacent aromatic ring, a 5- or 6-membered ring optionally substituted with methyl groups and/or optionally interrupted by an oxygen or sulphur atom, or R2 and R3 independently, which may be identical or different, can represent: a) a hydrogen atom, b) a radical comprising tert-butyl, 1-methylcyclohexyl, or 1-adamantyl, c) a radical â€”OR11 d) a polyether radical e) a halogen atom â€ƒR11 having the meaning given below, it being understood that at least one of the substituents R2 and R3 represents (b), R4 represents a hydrogen atom, a lower alkyl radical, a radical OR12, a polyether radical, a radical COR13 or a halogen atom, â€ƒR12 and R13 having the meanings given below, Râ€²4 represents a hydrogen atom or a halogen atom, R5 represents a hydrogen atom or a lower alkyl radical, R6 represents: (i) a hydrogen atom (ii) a lower alkyl radical (iii) a radical OR14 â€ƒR14 having the meaning given below, (iv) a radical of formula â€ƒRâ€² and Râ€³ having the meanings given below, R7, R8, R9 and R10, which may be identical or different, represent a hydrogen atom, a lower alkyl radical or an aryl radical, R11 and R12, which may be identical or different, represent a hydrogen atom, a lower alkyl radical, an optionally substituted aryl radical, an optionally substituted aralkyl radical, a monohydroxyalkyl or polyhydroxyalkyl radical or a lower acyl radical, R13 represents a lower alkyl radical, a radical OR15 or a radical â€ƒR15, Râ€² and Râ€³ having the meanings given below, R14 and R15 which may be identical or different, represent a hydrogen atom, a lower alkyl radical, an aryl radical, an optionally substituted aralkyl radical, a monohydroxyalkyl radical or a polyhydroxyalkyl radical, Râ€² and Râ€³, which may be identical or different, represent a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid residue, or alternatively, taken together with the nitrogen atom, form a heterocycle, as well as the salts thereof and the optical and geometrical isomers thereof.