Patent ID: 6197748
Filing Date: 2001-03-06
Classification: A61K,A61P,C07K

Abstract:
A compound selected from a group consisting of:PhCH.sub.2 CH.sub.2 --SO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleC.sub.6 H.sub.11 CH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleMe.sub.3 C--C.sub.6 H.sub.4 SO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleC.sub.10 H.sub.7 SO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleMe.sub.3 SiCH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleH--D-Arg-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-4-Apa-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-4-Gpa-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-4-Acg-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-homo-Lys-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-Arg-Sar-Arg-ThiazoleBnSO.sub.2 --(D)-Arg-Pro-Arg-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-4-Acg-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-(3-NH.sub.2 -Phe)-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-(4-NH.sub.2 -Phe)-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-3-Gpa-ThiazoleBnSO.sub.2 --(D)-Arg-Gly-4-Gpa-ThiazoleBoc-D-(2,3-Dap)-Gly-Arg-ThiazoleBoc-D-(2,4-Dab)-Gly-Arg-Thiazoleg-Abu-Gly-Arg-ThiazoleBoc-D-Orn-Gly-Arg-ThiazoleBoc-D-homoLys-Gly-Arg-ThiazoleBoc-Bag-Gly-Arg-ThiazoleBoc-D-4-Gpa-Gly-Arg-ThiazoleBoc-D-3-Gpa-Gly-Arg-ThiazoleBoc-D-4-Apa-Gly-Arg-ThiazoleBoc-D-3-Apa-Gly-Arg-ThiazoleBoc-D-4-Acg-Gly-Arg-ThiazoleBoc-D-(4-NH.sub.2 Phe)-Gly-Arg-ThiazoleBoc-D-(3-NH.sub.2 Phe)-Gly-Arg-ThiazoleBnSO.sub.2 --D-(2,3-Dap)-Gly-Arg-ThiazoleBnSO.sub.2 --D-(2,4-Dab)-Gly-Arg-ThiazoleBnSO.sub.2 --D-Orn-Gly-Arg-ThiazoleBnSO.sub.2 -Bag-Gly-Arg-ThiazoleBnSO.sub.2 --D-3-Gpa-Gly-Arg-ThiazoleBnSO.sub.2 --D-3-Apa-Gly-Arg-ThiazoleBnSO.sub.2 --D-(4-NH.sub.2 Phe)-Gly-Arg-ThiazoleBnSO.sub.2 --D-(3-NH.sub.2 Phe)-Gly-Arg-ThiazoleBnSO.sub.2 --D-(2,3-Dap)-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-(2,4-Dab)-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-Orn-Gly-Arg-BenzothiazoleBnSO.sub.2 -Bag-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-4-Gpa-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-3-Gpa-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-4-Apa-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-3-Apa-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-4-Acg-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-(4-NH.sub.2 Phe)-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-(3-NH.sub.2 Phe)-Gly-Arg-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(2,4-Dab)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(homoLys)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(4-Gpa)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(3-Gpa)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(4-Apa)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(3-Apa)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(4-NH.sub.2 Phe)-BenzothiazoleBnSO.sub.2 --D-Arg-Gly-(3-NH.sub.2 Phe)-BenzothiazoleMe.sub.3 SiCH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-Arg-BenzothiazoleBnSO.sub.2 --(D)-homo-Lys-Gly-Arg-BenzothiazoleBnSO.sub.2 --(D)-homo-Lys-Gly-Arg-BenzoxazolePhCH.sub.2 CH.sub.2 --SO.sub.2 --(D)-Arg-Gly-Arg-BenzothiazoleBnSO.sub.2 --(D)-Arg-Sar-Arg-BenzothiazoleBnSO.sub.2 --(D)-Arg-Pro-Arg-BenzothiazoleBnSO.sub.2 --(D)-Arg-Gly-4-Acg-BenzothiazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-BenzothiazolePhCH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-4-Acg-BenzothiazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-OxazoleBoc-D-(2,3-Dap)-Gly-Arg-OxazoleBoc-D-(2,4-Dab)-Gly-Arg-Oxazoleg-Abu-Gly-Arg-OxazoleBoc-D-Orn-Gly-Arg-OxazoleBoc-D-homoLys-Gly-Arg-OxazoleBoc-Bag-Gly-Arg-OxazoleBoc-D-4-Gpa-Gly-Arg-OxazoleBoc-D-3-Gpa-Gly-Arg-OxazoleBoc-D-4-Apa-Gly-Arg-OxazoleBoc-D-3-Apa-Gly-Arg-OxazoleBoc-D-4-Acg-Gly-Arg-OxazoleBoc-D-(4-NH.sub.2 Phe)-Gly-Arg-OxazoleBoc-D-(3-NH.sub.2 Phe)-Gly-Arg-OxazoleBnSO.sub.2 --D-(2,3-Dap)-Gly-Arg-OxazoleBnSO.sub.2 --D-(2,4-Dab)-Gly-Arg-OxazoleBnSO.sub.2 --D-Orn-Gly-Arg-OxazoleBnSO.sub.2 -Bag-Gly-Arg-OxazoleBnSO.sub.2 --D-4-Gpa-Gly-Arg-OxazoleBnSO.sub.2 --D-3-Gpa-Gly-Arg-OxazoleBnSO.sub.2 --D-4-Apa-Gly-Arg-OxazoleBnSO.sub.2 --D-3-Apa-Gly-Arg-OxazoleBnSO.sub.2 --D-4-Acg-Gly-Arg-OxazoleBnSO.sub.2 --D-(4-NH.sub.2 Phe)-Gly-Arg-OxazoleBnSO.sub.2 --D-(3-NH.sub.2 Phe)-Gly-Arg-OxazoleBnSO.sub.2 --D-Arg-Gly-(2,4-Dab)-OxazoleBnSO.sub.2 --D-Arg-Gly-(homoLys)-OxazoleBnSO.sub.2 --D-Arg-Gly-(4-Gpa)-OxazoleBnSO.sub.2 --D-Arg-Gly-(3-Gpa)-OxazoleBnSO.sub.2 --D-Arg-Gly-(4-Apa)-OxazoleBnSO.sub.2 --D-Arg-Gly-(3-Apa)-OxazoleBnSO.sub.2 --D-Arg-Gly-(4-NH.sub.2 Phe)-OxazoleBnSO.sub.2 --D-Arg-Gly-(3-NH.sub.2 Phe)-OxazoleBnSO.sub.2 --D-(2,3-Dap)-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-(2,4-Dab)-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-Orn-Gly-Arg-BenzoxazoleBnSO.sub.2 -Bag-Gly-Arg-BenzoxazoleBnSO.sub.2 -D4-Gpa-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-3-Gpa-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-4-Apa-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-3-Apa-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-4-Acg-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-(4-NH.sub.2 Phe)-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-(3-NH.sub.2 Phe)-Gly-Arg-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(2,4-Dab)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(homoLys)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(4-Gpa)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(3-Gpa)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(4-Apa)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(3-Apa)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(4-NH.sub.2 Phe)-BenzoxazoleBnSO.sub.2 --D-Arg-Gly-(3-NH.sub.2 Phe)-BenzoxazoleMe.sub.3 SiCH.sub.2 CH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-Arg-BenzoxazoleBnSO.sub.2 --(D)-homo-Lys-Gly-Arg-BenzoxazolePhCH.sub.2 CH.sub.2 --SO.sub.2 --(D)-Arg-Gly-Arg-BenzoxazoleBnSO.sub.2 --(D)-Arg-Sar-Arg-BenzoxazoleBnSO.sub.2 --(D)-Arg-Pro-Arg-BenzoxazoleBnSO.sub.2 --(D)-Arg-Gly-4-Acg-BenzoxazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-BenzoxazolePhCH.sub.2 CH.sub.2 SO.sub.2 --(D)-Arg-Gly-4-Acg-BenzoxazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-OxazolineBoc-D-(2,3-Dap)-Gly-Arg-OxazolineBoc-D-(2,4-Dab)-Gly-Arg-Oxazolineg-Abu-Gly-Arg-OxazolineBoc-D-Orn-Gly-Arg-OxazolineBoc-D-homoLys-Gly-Arg-OxazolineBoc-Bag-Gly-Arg-OxazolineBoc-D-4-Gpa-Gly-Arg-OxazolineBoc-D-3-Gpa-Gly-Arg-OxazolineBoc-D-4-Apa-Gly-Arg-OxazolineBoc-D-3-Apa-Gly-Arg-OxazolineBoc-D-4-Acg-Gly-Arg-OxazolineBoc-D-(4-NH.sub.2 Phe)-Gly-Arg-OxazolineBoc-D-(3-NH.sub.2 Phe)-Gly-Arg-OxazolineBnSO.sub.2 --D-(2,3-Dap)-Gly-Arg-OxazolineBnSO.sub.2 --D-(2,4-Dab)-Gly-Arg-OxazolineBnSO.sub.2 --D-Orn-Gly-Arg-OxazolineBnSO.sub.2 -Bag-Gly-Arg-OxazolineBnSO.sub.2 --D-4-Gpa-Gly-Arg-OxazolineBnSO.sub.2 --D-3-Gpa-Gly-Arg-OxazolineBnSO.sub.2 --D-4-Apa-Gly-Arg-OxazolineBnSO.sub.2 --D-3-Apa-Gly-Arg-OxazolineBnSO.sub.2 --D-4-Acg-Gly-Arg-OxazolineBnSO.sub.2 --D-(4-NH.sub.2 Phe)-Gly-Arg-OxazolineBnSO.sub.2 --D-(3-NH.sub.2 Phe)-Gly-Arg-OxazolineBnSO.sub.2 --D-Arg-Gly-(2,4-Dab)-OxazolineBnSO.sub.2 --D-Arg-Gly-(homoLys)-OxazolineBnSO.sub.2 --D-Arg-Gly-(4-Gpa)-OxazolineBnSO.sub.2 --D-Arg-Gly-(3-Gpa)-OxazolineBnSO.sub.2 --D-Arg-Gly-(4-Apa)-OxazolineBnSO.sub.2 --D-Arg-Gly-(3-Apa)-OxazolineBnSO.sub.2 --D-Arg-Gly-(4-NH.sub.2 Phe)-OxazolineBnSO.sub.2 --D-Arg-Gly-(3-NH.sub.2 Phe)-OxazolineBnSO.sub.2 --(D)-Arg-Gly-Arg-ImidazoleBnSO.sub.2 --(D)-Arg-Gly-Arg-PyridineBnSO.sub.2 --(D)-Arg-Gly-Arg-2-(1-methyl-tetrazole)BnSO.sub.2 --(D)-Arg-Gly-Arg-2-(4-methyl-tetrazole)MeSO.sub.2 --(D)-Arg-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(4-H.sub.2 NCH.sub.2 Phe)-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(4-H.sub.2 NCH.sub.2 Phg)-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(3-Py-Ala)-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(3-Me-3-Py-Ala)-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(3-Pip-Ala)-Gly-Arg-ThiazoleBnSO.sub.2 --(D)-(4-Pip-Ala)-Gly-Arg-Thiazole andBnSO.sub.2 --(D)-(3-Amidino-3-Pip-Ala)-Gly-Arg-Thiazole.