Patent ID: 6673784
Filing Date: 2004-01-06
Classification: C07C,C07D

Abstract:
A compound of Formula I wherein each of R1, R2, R3, and R4 is independently selected from hydrido, alkyl, aralkyl, halo, alkoxy, cyano, nitro, amino, alkylamino, N-acylamino, alkylsulfonyloxy, aminosulfonyl, N-(haloalkylcarbonyl)amino, peptidyl, amino acid residue, wherein R5 is selected from a monocyclic or bicyclic ring system containing a 5-membered heterocyclyl containing one N, a monocyclic or bicyclic ring system containing a 5-membered heterocyclyl containing at least one O, and a six-membered heterocycyl containing one N, wherein R5 is optionally substituted at a substitutable position with one or more substituents selected from alkyl, alkoxy, aryloxy, alkylthio, arylthio, halo, nitro, N-acylamino, amino, alkylamino, alkoxycarbonyl, amino acid residue and peptidyl; wherein R6 is selected from alkyl, aryl, aralkyl, heterocyclyl and heterocyclylalkyl, wherein R6 is optionally substituted at a substitutable position with a radical selected from alkoxy, aryloxy, alkylthio, arylthio, halo, nitro, N-acylamino, amino, alkylamino and alkoxycarbonyl; wherein Y is selected from fluoroalkyl and wherein Q is selected from alkoxy, arylocy, aralkyloxy, amino acid residue, peptidyl, and â€”NHR7; and wherein R7 is a radical selected from alkyl, aralkyl, and heterocyclylalkyl, wherein R7 is optionally substituted at a substitutable position with a radical selected from amino, nitrogen-containing heterocyclyl and alkylamino; or a pharmaceutically-acceptable salt or tautomer thereof.