Patent ID: 7662580
Filing Date: 2010-02-16
Classification: G01N

Abstract:
1. A method of diagnosing breast cancer in the subject, comprising: a) selecting protein makers, wherein the protein markers are the combination of cytokeratin 19, cathepsin D, ezrin, and slc9a3rl; b) detecting a level of expression of the selected protein markers in a biological fluid sample isolated from the subject by contacting the biological fluid sample with a targeting agent specific for a protein marker in the combination of the selected protein markers; c) detecting a level of expression of the selected protein markers in a control biological fluid sample by contacting the control sample with the targeting agent specific for a protein marker in the combination of the selected protein markers; and d) comparing the levels of expression of the selected protein markers in the biological fluid sample to the levels of expression of the same protein markers in the control sample, wherein the presence of breast cancer is indicated if the level of expression of the selected protein markers in the biological fluid sample is greater than the level of expression for the selected protein markers in the control sample.