Patent ID: 8835111
Filing Date: 2014-09-16
Classification: C12Q

Abstract:
1. A method of treating a human subject having multiple sclerosis (MS), the method comprising: obtaining a DNA sample from the subject; detecting in the DNA sample the presence of at least one T allele at single nucleotide polymorphism (SNP) rs2107538, at least one G allele at SNP rs1137933, and at least one A allele at SNP rs1318; correlating the presence of said at least one T allele at SNP rs2107538, at least one G allele at SNP rs1137933, and at least one A allele at SNP rs1318 with an increased MS disease severity, wherein the increased MS disease severity is measured by multiple sclerosis severity score or increased size and/or distribution of T2 brain lesions; and administering an MS therapeutic comprising interferon-beta or glatiramer acetate to the subject when at least one T allele at SNP rs2107538, at least one G allele at SNP rs1137933, and at least one A allele at SNP rs1318 is present.