Patent ID: 6313139
Filing Date: 2001-11-06
Classification: A61K,A61P,C07C,C07D

Abstract:
The method of treating a psychiatric disorder in an animal which comprises administering to said animal an effective amount of an I.sub.h channel modulator, wherein the I.sub.h channel modulator is a compound of formula (I) ##STR44##wherein A is the group ##STR45##wherein;P and S together with the ethylene group to which they are bonded form a pyridinediyl group, which group may be optionally substituted by one or more substituents selected from hydrogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, cyano, halogen, trifluoromethyl, phenyl and pyrrole, wherein the phenyl or pyrrole moieties may be optionally substituted with halogen or C.sub.1-3 alkyl;B is a bivalent radical derived from the aromatic group ##STR46##R.sub.1 represents one or more ring substituents selected from hydrogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, cyano, halogen, trifluoromethyl, phenoyl and pyrrole, wherein the phenyl or pyrrole moieties may be optionally substituted with halogen or C.sub.1-3 alkyl;R.sup.2 is NH.sub.2 ;R.sub.3, R.sub.4, and R.sub.5, which may be the same or different, each represents halogens C.sub.1-4 alkyl or hydrogen, or R.sup.4 and R.sub.5 together form a carbon-carbon bond;n is 0 or 1;or a physiologically acceptable salt or solvate thereof.