Patent ID: 6855847
Filing Date: 2005-02-15
Classification: C07B,C07C,C07F

Abstract:
1. A process for producing an optically active amide comprising a step of asymmetric hydrogenation of an α,β-unsaturated amide derivative in the presence of a transition metal complex containing a phosphine-phosphorane compound represented by the following general formula (21) and a transition metal selected from the group consisting of Ir, Rh, Ru, Pd, and Ni. (wherein R 11 and R 21 are the same or different, and each represents a linear or branched alkyl group having 1 to 6 carbon atoms, a linear or branched alkyl group having 1 to 6 carbon atoms which has at least one substituent (an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or a halogen atom), a cycloalkyl group having 3 to 7 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, a ring-substituted aralkyl group, a phenyl group, a phenyl group having at least one substituent (an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms which is substituted by at least one halogen atom, an alkoxy group having 1 to 6 carbon atoms, or a halogen atom, an amino group, an amino group substituted by an alkyl group, 3,4-methylenedioxy group, 3,4-ethylenedioxy group, or 3,4-propylenedioxy group), a five-membered heteroaromatic ring residual group, a naphthyl group, or a naphthyl group having substituent(s) (an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or a halogen atom); R 31 , R 41 , R 51 , and R 61 are the same or different, and each represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms, and each of R 31 and R 41 , R 41 and R 51 , and R 51 and R 61 may be together combined to form a ring containing at least one heteroatom; and R 71 and R 81 are the same or different, and each represents hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, a perfluoroalkyl group, a phenyl group, a phenyl group having at least one substituent (an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms which is substituted by halogen atom(s), an alkoxy group having 1 to 6 carbon atoms, or a halogen atom), an aralkyl group having 7 to 12 carbon atoms, or a ring-substituted aralkyl group).