Patent ID: 9169201
Filing Date: 2015-10-27
Classification: A61P,C07C,C07D

Abstract:
1. A compound of general formula (I) wherein: D is a substituted group selected from carbocyclic aryl, C L is a group selected from carbocyclic aryl, carbocyclic aryloxy-, carbocyclic arylalkoxy-, carbocyclic arylalketyl-, carbocyclic arylketyl-, carbocyclic aryl-N(R wherein L is optionally substituted with one, two, or three groups selected from halogen, CF 3 , hydroxyl, amido, optionally substituted C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, optionally substituted C 2-6 -alkynyl, optionally substituted C 3-6 -cycloalkyl, optionally substituted C 4-8 -cycloalkenyl, optionally substituted C 1-8 -alkyoxy, optionally substituted C 3-8 -alkylthio-, optionally substituted C 3-8 -cycloalkylalkoxy, optionally substituted C 3-8 -cycloalkylalkylthio, —NO 2 , or —CN, R 12 is selected from hydrogen or C 1-3 -alkyl; Z is —C(O)N(R R 2 is a group selected from hydrogen or C 1-8 -alkyl; Y is a group selected from —C(O)—, —O—, —NR R 26 is a group selected from hydrogen, or C 1-6 -alkyl, C 1-6 -perfluoroalkyl or fluoro; R 1 is a group selected from hydrogen, fluoro or C 1-8 -alkyl optionally substituted with fluoro up to perfluoro, R 27 is a group selected from hydrogen, C 1-6 -alkyl, hydroxyl, or fluoro; E is a group selected from C X is a group selected from phenylene, heterocyclic monoarylene, C M is a group selected from —C(O)NR R 30 is a group independently selected from hydrogen or C 1-6 -alkyl optionally substituted with fluoro up to perfluoro; T is a group selected from —(CHR A is a group selected from —(CHR R 36 is a group selected from hydrogen, C 1-6 -alkyl, hydroxyl, fluoro, or —(CH 2 ) p OR 38 ; p is 0 or 1; n is 0, 1, 2, or 3; m is 1 or 3; wherein n+m is 1, 2, or 3; R 38 is a group selected from hydrogen or optionally substituted C 1-3 -alkyl; R 39 is a group selected from —OH, —NHOH, —NH 2 ; Q is a group selected from oxygen or NR 43 ; R 43 is a group independently selected from C 1-6 -alklyl or hydrogen; and pharmaceutically acceptable salts, cocrystals and prodrugs thereof.