Patent ID: 6387912
Filing Date: 2002-05-14
Classification: A61K,A61P

Abstract:
A method of preventing or treating cerebral ischemia or strokes in a mammal in need of such treatment comprising administering to said mammal an effective amount of pyrimidine derivatives of the formula I whereA is NH or oxygen, B is hydrogen or methyl, C is hydrogen, methyl or hydroxyl, D is methyl, E is â€ƒD and E are together â€”CH2â€”CH2â€”NR1â€”CH2â€”, â€”CH2â€”NR1â€”CH2â€” or â€”CH2â€”NR1â€”CH2â€”CH2â€”, X is nitrogen, Y is CH2, CH2â€”CH2, CH2â€”CH2CH2 or CH2â€”CH, Z is nitrogen, carbon or CH, with it also being possible for the bond between Y and Z to be a double bond, n is the number 2, 3, or 4, R1 is hydrogen, a C1-C4-alkyl group, an acetyl or benzoyl group, a phenylalkyl C1-C4 radical or phenylalkoxy C2-C5 radical, with the aromatic moiety optionally being substituted by halogen, or C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, a naphthylalkyl C1-C3 radical, a phenylalkanone C2-C4 radical or a phenyl- or pyridylcarbamoylalkyl C2 radical, with it being possible for the phenyl or pyridyl group to be substituted by halogen, a C1-C3-alkyl group, a methoxy group and by a nitro or amino group, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is optionally monosubstituted, disubstituted or trisubstituted by halogen atoms, C1-C4-alkyl or trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano, thiomethyl or nitro groups and which can optionally be fused to a benzene nucleus which can optionally be monosubstituted or disubstituted by halogen atoms, C1-C4-alkyl or hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and which can optionally contain 1 nitrogen atom, or to a 5- or 6-membered ring which can contain 1-2 oxygen atoms, or can be substituted by a phenyl-C1-C2-alkyl- or -alkoxy group, with it being possible for the phenyl radical to be substituted by halogen, or a methyl, trifluoromethyl or methoxy group, R3 and R4 are, independently of each other, hydrogen or a C1-C4-alkyl group, or their physiologically tolerated salts.