Patent ID: 6828338
Filing Date: 2004-12-07
Classification: A61P,C07D

Abstract:
A compound having the structure: whereinX1, X4, X5, and X6 are each ring atoms defining a 6-membered heterocyclic ring; X1 and X4 are independently carbon or nitrogen; X5 and X6 are independently carbon, nitrogen, oxygen or sulfur; Z1 is phenyl or cycloalkyl; Z3 is a substituted phenyl ring, the substituents of the ring comprising an amidino, guanidino, amino, aminoalkyl, or a derivatized amidine which, upon hydrolysis, oxidation, reduction or elimination yields an amidino group, the phenyl ring being optionally further substituted with halogen, hydroxy or alkyl; and Z4 comprises a carbocyclic ring.