Patent ID: 6214877
Filing Date: 2001-04-10
Classification: A61P,C07B,C07C,C07D,C07F

Abstract:
A compound of formula I having the structure ##STR12##wherein:B is aryl;D is halogen, or aryl;R.sup.1 is hydrogen, alkyl of 1-6 carbon atoms, --SO.sub.2 Ph(OH)(CO.sub.2 H), --CH(R.sup.2)W, --CH.sub.2 CH.sub.2 Y, or --CH.sub.2 CH.sub.2 CH.sub.2 Y;R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, or aralkyl of 6-12 carbon atoms;W is --CO.sub.2 R.sup.3, --CONHOH, --CN, --CONHR.sup.3, aryl, --CHO, --CH.dbd.NOR.sup.3, or --CH.dbd.NHNHR.sup.3 ;Y is --W, --OCH.sub.2 CO.sub.2 R.sup.3, aryl, --C(.dbd.NOH)NH.sub.2, --OR.sup.3, --O(C.dbd.O)NR.sup.4 R.sup.5, --NR.sup.3 (C.dbd.O)OR.sup.3, --NR.sup.3 (C.dbd.O)NR.sup.4 R.sup.5, or --NR.sup.4 R.sup.5 ;R.sup.3 is hydrogen or alkyl of 1-6 carbon atoms;R.sup.4 and R.sup.5 are each, independently, hydrogen, or alkyl of 1-6 carbon atomsn is 2 to 5;C is --CONR.sup.6 R.sup.7 ;R.sup.6 and R.sup.7 are each, independently, hydrogen, alkyl of 1-18 carbon atoms, aryl, aralkyl of 6-20 carbon atoms, cycloalkyl of 3-10 carbon atoms, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.3, --(CH.sub.2).sub.m A;R.sup.8 is hydrogen, alkyl of 1-18 carbon atoms, aryl, aralkyl of 6-20 carbon atoms, cycloalkyl of 3-10 carbon atoms, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.3, --(CH.sub.2 CH.sub.2 CH.sub.2 O).sub.n CH.sub.3, or--(CH.sub.2).sub.m A;A is aryl, aryloxy, arylthio, arylsulfoxy, arylsulfonyl, --CHF.sub.2, --CH.sub.2 F, --CF.sub.3, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.3, --(CH.sub.2 CH.sub.2 CH.sub.2 O).sub.n CH.sub.3, --CO.sub.2 R.sup.3, --O(C.dbd.O)NR.sup.6 R.sup.7, or aralkyloxy;m is 2 to 16p is 2 to 12or a pharmaceutically acceptable salt thereof.