Patent ID: 6921755
Filing Date: 2005-07-26
Classification: A61K,Y10S

Abstract:
1. A method of stimulating tear secretion and mucin production in eyes comprising the step of administering to the eyes an effective amount of a preparation comprising a dinucleotide as depicted in Formulae II, II(a) and II(b), or a pharmaceutically acceptable salt thereof; and a physiologically compatible vehicle selected from the group consisting of aqueous electrolyte solutions, polyethers, polyvinyls, polymers of acrylic acid, lanolin, and glucosaminoglycans; whereby said preparation is effective in promoting tear secretion and mucin production in the eyes in a subject in need of such treatment: wherein: X is oxygen, imido, methylene or difluoromethylene; n=0 or 1; m=0 or 1; n+m=0, 1 or 2; and B and B′ are each independently a purine residue, as in Formula IIa, or a pyrimidine residue, as in Formula IIb, linked through the 9- or 1-position, respectively: wherein: R R R R wherein: R R R R or together R R