Patent ID: 6054482
Filing Date: 2000-04-25
Classification: A61P,C07C

Abstract:
A process for the preparation of a compound of Formula VII ##STR17## wherein n is an integer of from 5 containing less than 0.5% by weight of a compound of Formula VIII ##STR18## wherein n is as defined above and less than 20 ppm of an anion of a mineral acid comprising:(a) hydrolysis of a compound of Formula VII containing a compound of Formula VIII or of a compound of Formula VIII alone with a mixture of equal volumes of a concentrated mineral acid and water to afford an acid addition salt of a compound of Formula VII and(b) converting the acid addition salt of a compound of Formula VII by ion exchange to a compound of Formula VII containing less than 0.5% by weight of a compound of Formula VIII and less than 20 ppm of an anion of a mineral acid.