Patent ID: 6011563
Filing Date: 2000-01-04
Classification: A61N

Abstract:
A system for simulating and controlling a photodynarmic therapy treatment of a sensitized tumor, said system comprising:a) a computer system, including a processor for processing input signals and data, simulating a photodynamic therapy treatment of a sensitized tumor to provide a profile of a transient variation of triplet oxygen concentration and determine spatial concentrations of singlet oxygen and photosensitizer as a function of the transient variation of triplet oxygen concentration, determining a fractionation cycle, and generating control signals and output display;b) a computer memory included in said computer system and connected to said processor, said memory storing input signals and data, storing results of the simulation and fractionation cycle, and storing the control signals and output displays for subsequent communication with the processor;c) input means connected to the processor for transmitting input data regarding triplet oxygen diffusion rates, reaction rate constants, sensitizer parameters, laser operating parameters, starting oxygen parameters, and laser cycle parameters;d) output means connected to the processor for displaying the input data and for displaying the selected results of the simulated photodynamic therapy treatment;e) a light system for generating a light beam, said light system being connected to the processor for receiving and transmitting light control signals from and to the processor; andf) shutter means positioned between said light system and a sensitized tumor for selectively directing the light beam from said light system at the sensitized tumor during a light interval of the fractionation cycle, and then directing the light beam away from the sensitized tumor during a dark interval of the fractionation cycle, said shutter means in electrical communication with said processor for receiving and transmitting shutter control signals from and to the processor, whereby said computer simulates and controls said light system and the fractionation cycle for the photodynamic therapy treatment of the sensitized tumor.