Patent ID: 8354092
Filing Date: 2013-01-15
Classification: A61P,C07D,C12Q,G01N

Abstract:
1. A compound comprising the Formula IIa 2 : or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof, wherein: G is a bond or is selected from the group consisting of cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl, wherein said cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl are substituted or unsubstituted; n is 0, 1, 2 or 3; X is a bond or is selected from the group consisting of X′ is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, and Z′-D, where D comprises a charged moiety that is at least one of a cation or anion, —SO Y is H or is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, —SO R is H, or is selected from the group consisting of Z is a bond or is selected from the group consisting of —C(O)—NH—CH wherein at least one of X′ or Y is comprised of an ionizable group.