Patent ID: 7449478
Filing Date: 2008-11-11
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I): wherein R 1 is (CR c R d ) m —X —R a or (CR c R d ) n —X —R b , in which m is 3-5; n is 2-5; X is N(R e ),O, or S, or X and R a or X and R b , taken together, is heteroaryl; R a is H, C 1 -C 6 alkyl, C 3 -C 15 cycloalkyl, C 3 -C 15 heterocycloalkyl, heteroaryl, or aryl optionally substituted with OH, halogen, C 3 -C 6 alkyl, C 3 -C 15 cycloalkyl, C 3 -C 15 heterocycloalkyl, C 1 -C 6 alkoxy, aryloxy, heteroaryloxy, heteroaryl, aryl, NO 2 , CN, COOR f , or C(O)R f , or R a and X, taken together, is heteroaryl; R b is H, C 1 -C 6 alkyl, C 3 -C 15 cycloalkyl, C 3 -C 15 heterocycloalkyl, heteroaryl, or aryl optionally substituted with OH, halogen, C 3 -C 6 alkyl, C 3 -C 15 cycloalkyl, C 3 -C 15 heterocycloalkyl, aryloxy, heteroaryloxy, heteroaryl, aryl, NO 2 , CN, COOR f , or C(O)R f , or R b and X, taken together, is heteroaryl; each R c , independently, is H, C 1 -C 6 alkyl, aryl, or heteroaryl; and each R d , independently, is H, C 1 -C 6 alkyl, aryl, or heteroaryl; each of R e and R f , independently, being H, C 1 -C 6 alkyl, aryl, or heteroaryl; each of R 2 and R 3 is H; and one of R