Patent ID: 7425608
Filing Date: 2008-09-16
Classification: C07K,Y02P

Abstract:
1. A method for producing substantially pure metallopeptides, comprising the steps of: (a) synthesizing a sequence of the formula Aaa-MBD-Baa cleavably bound to solid phase, wherein where: SPG is an orthogonal S-protecting group bound to a sulfur atom forming a part of an amino acid side chain, and R is in each instance independently hydrogen or an amino acid side chain; (b) in a single pot, deprotecting the sulfur atom protected by an orthogonal S-protecting group by cleaving the said orthogonal S-protecting group without cleaving the sequence from the solid phase and complexing a metal ion to the MBD; and (c) cleaving the sequences from the solid phase, thereby providing a metallopeptide of the structure: wherein