Patent ID: 6229041
Filing Date: 2001-05-08
Classification: C07C,Y02P

Abstract:
A method for producing a S-aryl-L-cysteine of the formula: ##STR5##comprising:(i) contacting an amino acid selected from the group consisting of compounds of the formula: ##STR6##with a coupling agent under conditions sufficient to produce a metal-amino acid complex, wherein the coupling agent comprises a metal, metal oxide, or mixtures thereof; and(ii) contacting the metal-amino acid complex with an aryl halide of the formula Ar-X under conditions sufficient to produce said S-aryl-L-cysteine;whereinAr is a substituted or unsubstituted aryl group selected from the group consisting of phenyl, naphthyl, pyridyl, furyl, thiophenyl, pyrazyl, and pyrrolyl,X is a halide,P.sup.1 is H or an amine protecting group, andP.sup.2 is H or a carboxylic acid protecting group.