Patent ID: 6555539
Filing Date: 2003-04-29
Classification: A61P,B22D,C07D,C07F

Abstract:
A compound represented by Formula I: wherein R1 is a substituted or unsubstituted aryl, a heteroaryl containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, carbocycle, or a heterocycle containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, or wherein R4 is H or lower alkyl, and X is a substituted or unsubstituted alkyl, aryl, a heteroaryl containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, carbocycle, or a heterocycle containing 5-10 ring atoms and 1-3 nitrogen heteroatoms; and R2 is a substituted or unsubstituted aryl, a heteroaryl containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, carbocycle, or a heterocycle containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, or wherein R4 is H or lower alkyl, and X is a substituted or unsubstituted alkyl, aryl, heteroaryl containing 5-10 ring atoms and 1-3 nitrogen heteroatoms, carbocycle, or a heterocycle containing 5-10 ring atoms and 1-3 nitrogen heteroatoms; ora pharmaceutically acceptable salt of a compound of the Formula I; or a prodrug or pharmaceutically active metabolite of a compound of the Formula I, or a pharmaceutically acceptable salt of a prodrug or metabolite thereof.