Patent ID: 6392039
Filing Date: 2002-05-21
Classification: A61P,C07D

Abstract:
A process for preparing (R)-(+)-3-{1-[2-(4-benzoyl-2-(3,4-difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperid-4-yl }1,1-dimethylurea, and the salts, solvates and/or hydrates thereof, of formula: wherein (+)-[2- [2-(4-amino-4-phenylpiperid-1yl)ethyl]-2-(3,4-difluoro-phenyl)morpholin-4-yl]phenylmethanone, of formula: is reacted, in an inert solvent, first with a reactive derivative of carbonic acid in the presence or absence of base, and then with dimethylamine, and the compound of formula (I) thus obtained is optionally converted into a salt thereof with pharmaceutically acceptable mineral or organic acids.