Patent ID: 6649648
Filing Date: 2003-11-18
Classification: A61K,A61P,A61Q,C07C,C12P

Abstract:
A method for the treatment or prophylaxis of a cancerous disease which comprises administering to a subject in need thereof a therapeutically effective amount of at least one compound of the formula I: whereinZ is H; R1 is H or RACO, where RA is C1-10 alkyl or an amino acid; R2 is H, OH, or ORB, where RB is an amino acid or CORA, where RA is C1-10 alkyl or an amino acid; W is H; and A and B taken together form a six membered ring selected from whereinR4 is H, CORD, CO2RC, CORE, COOH, CORC, or CONHRE, where RD is H, OH, C1-10 alkyl or an amino acid, RC is C1-10 alkyl, RB is H, C1-10 alkyl or an amino acid, and RE is H, C1-10 alkyl or an amino acid; R5 is H, CO2RC, or CORCORE, where RC is C1-10 alkyl, and RE is H, C1-10 alkyl or an amino acid, and with the proviso that where the two R5 groups are attached to the same group they are identical or different; X is O, N, or S; and Y is whereR7 is H, or C1-10 alkyl, and with the provisos that compounds whereR1 and W are H, Z is H or OCH3 and R2 is H or OH, R4 is COOH or CO2RC and RC is C2 alkyl, A and B taken together are a six membered ring of the formula Y is andR7 is H, and whereR1 and W are H, Z is H, R2 is OH, A and B taken together are a six membered ring of the formula Y is R4 is CORD where RD is H, OH, C1-10 alkyl or amino acid, and R7 is H, are excluded.