Patent ID: 7576190
Filing Date: 2009-08-18
Classification: A61K,A61P,C07K

Abstract:
1. A heterologous fusion protein comprising a first polypeptide fused to a second polypeptide wherein the C-terminus of the first polypeptide is fused to the N-terminus of the second polypeptide via a linker and wherein the first polypeptide is a human FGF-21 mutein selected from the group consisting of: (a) SEQ ID NO:1 having mutations Leu118Cys-Ala134Cys; (b) SEQ ID NO:1 having mutations Leu21Cys-Leu33Cys; (c) SEQ ID NO:1 having mutations Ala26Cys-Lys122Cys; (d) SEQ ID NO:1 having mutations Ala31Cys-Gly43Cys; (e) SEQ ID NO:1 having mutations Leu21Cys-Leu33Cys/Leu118Cys-Ala134Cys; (f) SEQ ID NO:1 having mutations IIe52Glu-Ser163Glu/Leu 118Cys-Ala134Cys; and (g) SEQ ID NO:1 having mutations Leu118Cys-Ala134Cys/Ser167Ala; wherein the second polypeptide is selected from the group consisting of: (a) the Fc portion of an immunoglobulin; (b) fragments of the Fc portion of an immunoglobulin; (c) human albumin; and (d) fragments of human albumin; and wherein the linker is selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, [SEQ ID NO: 5]