Patent ID: 6258838
Filing Date: 2001-07-10
Classification: A61P,C07C,C07D

Abstract:
A compound of general formula ##STR88##whereinx represents 1 or 2;A represents an oxygen atom;B represents a hydrogen or halogen atom;R represents a phenyl, pyridyl, indolyl, indazolyl, pyrimidinyl or thienyl group, each of which may be optionally substituted by one or more substituents independently selected from a halogen atom or an amino, cyano, carboxyl, hydroxyl, nitro, C.sub.1 -C.sub.6 -alkyl, halo-C.sub.1 -C.sub.6 -alkyl, --N(R.sup.1)--C(.dbd.O)--R.sup.2, --C(O)NR.sup.3 R.sup.4, --NR.sup.5 R.sup.6, C.sub.3 -C.sub.8 -cycloalkyl, 3- to 8-membered heterocyclyl, C.sub.3 -C.sub.8 -cycloalkyloxy, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.6 -alkylsulphinyl or C.sub.1 -C.sub.6 -alkylsulphonyl group, or a C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylamino, phenoxy, benzyl, C.sub.1 -C.sub.6 -alkylthio or phenylthio group optionally substituted by one or more substituents independently selected from a halogen atom or an amino, cyano, carboxyl, hydroxyl, nitro, 1-pyrrolidinyl, 1-piperidinyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, (di)C.sub.1 -C.sub.6 -alkylamino, halo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxycarbonyl or one of the following groups: ##STR89##R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.2 represents a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.3 and R.sup.4 each independently represent a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.5 represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.6 represents a C.sub.3 -C.sub.8 -cycloalkyl group and, additionally, a C.sub.1 -C.sub.6 -alkyl group when R.sup.5 is not a hydrogen atom;R.sup.7 represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.8 represents a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.9 represents a hydrogen atom or a hydroxyl group; andR.sup.10 represents a hydrogen atom or a phenyl or imidazolyl group;with the proviso that when R represents a substituted phenyl, indolyl or indazolyl group, the substituent or substituents present do not comprise an amido, carboxyl, (di)C.sub.1 -C.sub.6 -alkylamido or C.sub.1 -C.sub.6 -alkoxycarbonyl group in an ortho position; or a pharmaceutically acceptable salt or solvate thereof.