Patent ID: 6077854
Filing Date: 2000-06-20
Classification: A61P,C07D

Abstract:
A compound of formula (1) ##STR21## wherein L is --XR;Z is a group (A) or (B): ##STR22## X is --O--, --S(O).sub.m -- or --N(R.sup.b)--, where m is zero or an integer 1 or 2;R.sup.b is hydrogen or an optionally substituted alkyl group;R is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group;R.sup.3 is hydrogen, fluorine, hydroxy or an optionally substituted straight or branched alkyl group;R.sup.4 is hydrogen, --(CH.sub.2).sub.t Ar or --(CH.sub.2).sub.t --Ar--(L.sup.1).sub.n --Ar', where t is zero or an integer 1, 2 or 3 and n is zero or an integer 1;R.sup.5 is --(CH.sub.2).sub.t Ar or --(CH.sub.2).sub.t --Ar--(L.sup.1).sub.n --Ar';R.sup.6 is hydrogen, fluorine, or an optionally substituted alkyl group;R.sup.7 is hydrogen, fluorine, an optionally substituted straight or branched alkyl group, or --OR.sup.c, where R.sup.c is hydrogen, formyl, alkoxyalkyl, alkanoyl, carboxamido, thiocarboxamido or an optionally substituted alkyl or alkenyl group;L.sup.1 is a divalent linking group;Ar is an optionally substituted monocyclic or bicyclic aryl group, optionally containing one or more heteroatoms selected from oxygen, sulphur and nitrogen atoms;Ar' is Ar, --COAr, --SO.sub.2 Ar, --SO.sub.2 NHAr, --SO.sub.2 NAlk.sup.1 Ar, --SO.sub.2 N(Ar).sub.2, --CONHAr, --CONAlk.sup.1 Ar, --CON(Ar).sub.2, --NAlk.sup.1 SO.sub.2 Ar, --NHSO.sub.2 Ar, --N(SO.sub.2 Ar).sub.2, --NHSO.sub.2 NHAr, --NAlk.sup.1 SO.sub.2 NHAr, --NHSO.sub.2 NAlk.sup.1 Ar, --NAlk.sup.1 SO.sub.2 NAlk.sup.1 Ar, --NHSO.sub.2 N(Ar).sub.2, --NAlk.sup.1 SO.sub.2 N(Ar).sub.2, --NHCOAr, --NAlk.sup.1 COAr, --N(COAr).sub.2, --NHCONHAr, --NAlk.sup.1 CONHAr, --NHCONAlk.sup.1 Ar, --NAlk.sup.1 CONAlk.sup.1 Ar, --NHCO.sub.2 Ar, --NAlk.sup.1 CO.sub.2 Ar, --CSNHAr, --CSNAlk.sup.1 Ar, --CSNAlk.sup.1 Ar, --CSN(Ar).sub.2, --NHCSAr, --NAlk.sup.1 CSAr, --N(CSAr).sub.2, --NHCSNHAr, --NAlk.sup.1 CSNHAr, --NHCSNAlk.sup.1 Ar, --NAlk.sup.1 CSNAlk.sup.1 Ar, --SO.sub.2 NHet, --CONHet, --CSNHet, --NHSO.sub.2 NHet, --NHCONHet, --NHCSNHet, --SO.sub.2 NH(Het'), --CONH(Het'), --CSNH(Het'), --NHSO.sub.2 NH(Het'), --NHCONH(Het') or --NHCSNH(Het');Alk.sup.1 is a straight or branched C.sub.1-6 alkylene, C.sub.2-6 alkenylene or C.sub.2-6 alkynylene chain optionally interrupted by one, two or three --O-- or --S-- atoms or --S(O)p-- or --N(R.sup.b)-- groups, where p is an integer 1 or 2;NHet is an optionally substituted C.sub.5-7 heterocyclic amino group optionally containing one or more additional --O-- or --S-- atoms or --N(R.sup.b)--, --CO-- or --CS-- groups;Het' is an optionally substituted C.sub.5-7 monocyclic carbocyclic group optionally containing one or more --O-- or --S-- atoms or --N(R.sup.b)-- groups; andthe salts, solvates, hydrates, prodrugs and N-oxides thereof;with the proviso that when Z is (A), X is --O--, R.sub.3, R.sub.4, R.sub.6 and R.sub.7 are hydrogen, R.sup.5 is --(CH.sub.2).sub.t Ar, and Ar is unsubstituted phenyl, unsubstituted pyridyl or pyridyl substituted with methoxy, then R is other than methyl or benzyl.