Patent ID: 6683166
Filing Date: 2004-01-27
Classification: C07H,C12N,C12Q

Abstract:
A modified oligonucleotide or derivative thereof, wherein the modification comprises substitution, for one or more phosphodiester linkages between 2â€² and 5â€² position of adjacent nucleosides, with a two to three atom long internucleoside linkage wherein at least one of the atoms making up the internucleoside linkage is nitrogen, oxygen, and sulfur, with the remainder being carbon wherein the internucleoside linkages are independently selected from the group of: wherein R6 is H, lower alkyl, OMe, OH, heteroalkyl, or aryl; and wherein R8 is CH2F, or when both R8 are taken together with the atom to which they are attached, form a 4-membered or 6-membered ring where (R8)2 is â€”CH2â€”X1â€”CH2â€”, or â€”(CH2)2â€”X1â€”(CH2)2â€”; wherein X1 is selected from the group consisting of NH, NMe, NEt, NPr, S, SO, SO2, O, CF2 and CHF.