Patent ID: 7893200
Filing Date: 2011-02-22
Classification: A61K,A61P,C07K

Abstract:
1. A monomeric soluble form of a member of the CD83 family of proteins (monomeric CD83 protein) selected from the group consisting of i) a soluble CD83 protein consisting of amino acid residues 20 to 144 of SEQ ID NO: 2; ii) a soluble CD83 protein consisting of amino acid residues 20 to 145 of SEQ ID NO:2, iii) a soluble CD83 protein consisting of amino acid residues 1 to 129 of SEQ ID NO: 8; and iv) a soluble CD83 protein consisting of amino acid residues 1 to 130 of SEQ ID NO:8; wherein in each of i) through iv) the third or fifth cysteine residue is substituted with an amino acid residue selected from the group consisting of serine, alanine, glycine, valine, threonine, aspartic acid, glutamic acid, arginine, lysine, histidine, asparagine, glutamine and tyrosine; wherein said third cysteine residue corresponds to residue 100 of SEQ ID NO: 2 or residue 85 of SEQ ID NO: 8, and wherein said fifth cysteine residue corresponds to residue 129 of SEQ ID NO: 2 or residue 114 of SEQ ID NO: 8.