Patent ID: 6251904
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A compound of the formula (IA) or (IB): ##STR143##or a pharmaceutically or veterinarily acceptable salt thereof, or a pharmaceutically or veterinarily acceptable solvate of either entity, wherein R.sup.1 is C.sub.1 to C.sub.3 alkyl optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group is optionally substituted by one or more substitutents selected from C.sub.1 to C.sub.4 alkoxy; halo; CN; CF.sub.3 ; OCF.sub.3 or C.sub.1 to C.sub.4 alkyl wherein said C.sub.1 to C.sub.4 alkyl group is optionally substituted by C.sub.1 to C.sub.4 haloalkyl or haloalkoxy either of which is substituted by one or more halo atoms;R.sup.2 is C.sub.1 to C.sub.6 alkyl;R.sup.13 is OR.sup.3 or NR.sup.5 R.sup.6 ;R.sup.3 is C.sub.1 to C.sub.6 alkyl optionally substituted with one or two substituents selected from C.sub.3 to C.sub.5 cycloalkyl, OH, C.sub.1 to C.sub.4 alkoxy, benzyloxy, NR.sup.5 R.sup.6, phenyl, furanyl and pyridinyl; C.sub.3 to C.sub.6 cycloalkyl; 1-(C.sub.1 to C.sub.4 alkyl) piperidinyl; tetrahydrofuranyl or tetrahydropyranyl; and wherein said C.sub.1 to C.sub.5 alkyl or said C.sub.1 to C.sub.4 alkoxy groups are optionally terminated by haloalkyl;R.sup.4 is SO.sub.2 NR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 are each independently selected from H and C.sub.1 to C.sub.4 alkyl optionally substituted with C.sub.3 to C.sub.5 cycloalkyl or C.sub.1 to C.sub.4 alkoxy, or, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholinyl group;R.sup.7 and R.sup.8, together with the nitrogen atom to which they are attached, form a 4-R.sup.10 -piperazinyl group optionally substituted with one or two C.sub.1 to C.sub.4 alkyl groups and optionally in the form of its 4-N-oxide;R.sup.10 is H; C.sub.1 to C.sub.4 alkyl optionally substituted with one or two substituents selected from OH, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, phenyl optionally substituted with C.sub.1 to C.sub.4 alkoxy, benzodioxolyl and benzodioxanyl; C.sub.3 to C.sub.6 alkenyl; pyridinyl or pyrimidinyl; andHet is a C-linked 6-membered heterocyclic group containing one or two nitrogen atoms, optionally in the form of its mono-N-oxide, or a C-linked 5-membered heterocyclic group containing two or three nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy or NHR.sup.15 wherein R.sup.15 is H, C.sub.1 to C.sub.4 alkyl or C.sub.1 to C.sub.4 alkanoyl and halo is Br, Cl, F or l.