Patent ID: 6080727
Filing Date: 2000-06-27
Classification: A61K,C12N

Abstract:
A method of inhibiting proliferation of human melanoma cancer cells comprising: administering to a patient having a melanoma a c-myc oligonucleotide in an amount sufficient to inhibit said proliferation, wherein said c-myc oligonucleotide is complementary to a nucleotide sequence of human c-myc mRNA; andwherein said c-myc oligonucleotide is at least 10 bases in length and inhibits proliferation of cultured human melanoma cells by at least 10% at a concentration of 10 .mu.M compared to proliferation of cultured said human melanoma cells in the absence of said c-myc oligonucleotide and said human melanoma cells are cultured in the presence of serum at 37.degree. C.