Patent ID: 9035027
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,G01N,Y02A

Abstract:
1. A binding protein capable of binding at least IL-1α and IL-1β, comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain comprising CDRs 1-3 from SEQ ID NO: 52; VD2 is a second heavy chain variable domain comprising CDRs 1-3 from SEQ ID NO: 68; C is a heavy chain constant domain; X1 is a linker; X2 is an Fc region; and n is 1; and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain comprising CDRs 1-3 from SEQ ID NO: 53; VD2 is a second light chain variable domain comprising CDRs 1-3 from SEQ ID NO: 69; C is a light chain constant domain; X1 is a linker; n is 1 for (X1)n; and (X2)n is absent.