Patent ID: 8212059
Filing Date: 2012-07-03
Classification: A61P,C07C,C07J

Abstract:
1. A process for producing a compound represented by Formula (1): said process comprising the steps of: irradiating a compound represented by Formula (2): with UV to open the B-ring of the steroid skeleton of the compound; and isomerizing the resulting compound to obtain said compound of Formula (1), wherein said compound represented by Formula (2) is obtained by a process comprising the steps of: subjecting a compound represented by Formula (3): wherein R 1 and R 2 , which may be the same or different, are each a substituted silyl group, to a formation of a conjugated diene in the B-ring of the steroid skeleton of the compound by brominating the methylene group at the 7-position in the B-ring of the steroid skeleton using a brominating agent in the presence of a radical initiator selected from benzoyl peroxide or 2,2′-azobis(isobutyronitrile), and then dehydrobrominating the resulting group in the presence of a base; subjecting the resulting compound to a formation of an allyl alcohol moiety via ring-opening of the epoxy group in the presence of a Lewis acid to obtain a compound represented by Formula (4): reacting the obtained compound with 2-bromo-N-(2,2,3,3,3-pentafluoropropyl) acetamide to obtain a compound represented by formula (5): replacing R