Patent ID: 8586039
Filing Date: 2013-11-19
Classification: A61K,A61P,C07K

Abstract:
1. An isolated DNA that encodes a modified antibody comprising two H chain V regions and two L chain V regions of an antibody, showing TPO agonist action by crosslinking TPO receptors of the same cell, wherein: said modified antibody is a dimer of single chain Fv comprising one H chain V region and one L chain V region, wherein the H chain V region and L chain V region are connected through a peptide linker having 15 amino acids, and at least one of the H chain V regions comprises a polypeptide having a sequence encoded by SEQ ID NO. 66 or SEQ ID NO. 94, and/or at least one of the L chain V regions comprises a polypeptide having a sequence encoded by SEQ ID NO. 75 or SEQ ID NO. 104.