Patent ID: 6417009
Filing Date: 2002-07-09
Classification: C07C,C07D,C07K,Y10S

Abstract:
A linker lipid for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode in which the membrane is either in part or totally made up of the linker lipid, the linker lipid comprising within the same molecule a hydrophobic region spanning the membrane, an attachment group used to attach the molecule to an electrode surface, a hydrophilic region intermediate said hydrophobic region and the attachment group, and a polar head group region attached to the hydrophobic region at a site remote from the hydrophilic region wherein said attachment group has a cross sectional area greater than the cross sectional area of the hydrophilic region, said attachment group having the following structure:Xâ€”Y[(CH2)nZ(CH2)pSR]m where X is either a carbon, nitrogen or oxygen to which the hydrophilic region is attached, Y is a carbon or if X is a carbon Y is a nitrogen, m is between 1 to 3 if Y is a carbon and between 1 to 2 if Y is a nitrogen, where Z is O, NH, NR1, an amide or ketone, and where n is between 1 and 5 and p is between 2 and 5, unless Y is N, in which case n is between 2 and 5, and where R1 is an alkyl chain containing between 1 and 4 carbon atoms, and R is â€”SH, â€”SCH2Ph, â€”SCH2CO2H, â€”SCH2CH2CO2H, â€”SCH2CH2OH, â€”SCH2CH2CH2OH, â€”SCH3, â€”SCH2CH3, â€”SGH2CH2CH3, â€”SCH2CO2CH3, â€”SCH2CO2CH2CH3, an alkyl chain containing between 1 and 4 carbon atoms, or an aryl group.