Patent ID: 8278476
Filing Date: 2012-10-02
Classification: C07B,C07C

Abstract:
1. A process for producing an α-substituted ester of the general formula [4], comprising: reacting a fluorosulfuric acid ester of α-hydroxyester of the general formula [1] with a Grignard reagent of the general formula [3] in the presence of a zinc catalyst of the general formula [2] where R 1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, an aromatic ring group, or a substituted aromatic ring group; R 2 represents an alkyl group or a substituted alkyl group; R 3 represents an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, an aromatic ring group, or a substituted aromatic ring group; when R 1 is any substituent group other than hydrogen atom, R 1 and R 2 may form a ring structure by a covalent bond between carbon atoms thereof through or without a heteroatom; X 1 represents a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an acetate group (CH 3 CO 2 ), or a triflate group (CF 3 SO 3 ); and X 2 represents a chlorine atom, a bromine atom or an iodine atom.