Patent ID: 6610310
Filing Date: 2003-08-26
Classification: A61K,A61P,Y10S

Abstract:
A method for inducing or enhancing mucosal immune responses to antigens comprising administering an antigen in conjunction with a water soluble polyanionic polymer mucosal adjuvant via a mucosal route, or administering an antigen separately from a water-soluble polyanionic polymer mucosal adjuvant wherein each said antigen and adjuvant are administered via a mucosal route, said adjuvant comprising a water-soluble polyanionic polymer having anionic constitutional repeating units, wherein the polyanionic polymer is a polyanionic heteropolymer, and further wherein the polyanionic heteropolymer contains two distinct anionic constitutional repeating units, wherein the units are selected from acrylic acid and either vinylsulphonic acid, vinylbenzenesulphonic acid, or acrylamidomethylpropanesulfonic acid.