Patent ID: 8962581
Filing Date: 2015-02-24
Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
1. A method of detecting a presence of invasive glioblastoma in a subject and sensitizing the subject to a therapeutic treatment of invasive glioblastoma that targets non-migrating glioblastoma cells, the method comprising the steps of: receiving a sample comprising glioblastoma cells from the subject wherein the subject is suspected of having glioblastoma; adding a first reagent capable of binding to a marker comprising SEQ ID NO. 2 to a mixture comprising the sample; subjecting the mixture to conditions that allow detection of the binding; sensitizing the subject by reducing an expression level of the marker comprising SEQ ID NO. 2; wherein the reduced level of the marker comprising SEQ ID NO. 2 switches invasive glioblastoma cells in the subject to non-migrating cancer cells that are sensitive to a therapeutic invasive glioblastoma that targets the non-migrating glioblastoma cells.