Patent ID: 6867320
Filing Date: 2005-03-15
Classification: C07C,C07D

Abstract:
1. A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents a linear or branched alkyl group having 3 to 8 carbon atoms, a group Ra represented by the following formula: or a group Rb represented by the following formula: wherein k in the substituent Ra represents 0 or an integer of 1 to 3; R 1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R 1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms; Q in the group Rb represents a monocyclic or bicyclic aryl group, and Q may contain 1 or 2 heteroatoms; A 1 represents a single bond or an alkylene (a) having 1 to 3 carbon atoms, and the alkylene (a) may be substituted with a lower alkyl group having 1 to 4 carbon atoms or phenyl group; A 2 represents a single bond, oxygen atom, sulfur atom, —S(O)—, —S(O) 2 —, or —N(R 4 )— (wherein, when A 2 represents oxygen atom, sulfur atom, —S(O)—, —S(O) 2 —, or —N(R 4 )—, A 1 represents ethylene or trimethylene); R 2 and R 3 both or each independently represent hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, phenyl group, fluorine atom, chlorine atom, bromine atom, trifluoromethyl group, an —OR 5 group, an —N(R 6 ) 2 group, an —NHCOR 7 group, or an NHSO 2 R 8 group, wherein R 4 , R 6 , and R 7 each independently represent hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, and R 5 and R 8 represent a lower alkyl group having 1 to 4 carbon atoms; Z represents hydrogen atom, fluorine atom, chlorine atom, nitro group, amino group, methyl group, or an OR 9 group wherein R 9 represents hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; the substituent Ar represents a substituent selected from the group consisting of condensed bicyclic substituents of ArI, ArII, ArIII, ArIV, ArV, ArVI, ArVII, ArVIII, ArIX, ArX, ArXI, and ArXII represented by the following formulas: which bind at any of the positions of a, b, c, and d on the rings, and wherein the substituent X 1 in the group ArI represents hydrogen atom, a —OR 10 group, a —N(R 11 )(R 12 ) group, a —SO 2 R 13 group, or carboxyl group, wherein R 10 represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, or a (CH 2 ) i R 14 group wherein i represents an integer of 1 to 3, and R 14 represents hydroxyl group, carboxyl group, or N,N-dimethylcarbamoyl group, R 11 represents hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, R 12 represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, 2-hydroxyethyl group, a —COR 15 group, or a SO 2 R 16 group, wherein R 15 represents amino group, a lower alkyl group having 1 to 4 carbon atoms, hydroxymethyl group, aminomethyl group, dimethylaminomethyl group, phenyl group, or furyl group, and R 13 and R 16 each independently represent a lower alkyl group having 1 to 4 carbon atoms, amino group, methylamino group, or dimethylamino group; in the group ArII, W represents oxygen atom, sulfur atom, or NX 8 , the substituent X 2 represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, or carboxyl group, the substituent X 3 represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, acetyl group, formyl group, carboxymethyl group, or hydroxymethyl group, the substituent X 8 represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, a saturated cyclic alkyl group having 3 to 7 carbon atoms, or a (CH 2 ) j R 17 group wherein j represents an integer of 1 to 3, and R 17 represents hydroxyl group or carboxyl group; the substituent X 4 in the group ArIII represents hydrogen atom, methyl group, methoxy group, amino group, methylamino group, or dimethylamino group; in the group ArIV, X 6 represents oxygen atom, sulfur atom, or NX 9 , and the substituents X 5 and X 9 both represent hydrogen atom or methyl group; the substituent X 7 in the groups ArV and ArXI represents hydrogen atom or methyl group; M in the groups ArVII and ArVIII represents sulfur atom or NX 8 ; the substituent X 10 in the group ArVII represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, carboxyl group, acetyl group, formyl group, or an OR 22 group (wherein, when M in the group ArvII represents sulfur atom, the substituent X 10 represents hydrogen atom or a linear or branched saturated alkyl group having 1 to 4 carbon atoms), wherein R 22 represents hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; the substituent X 11 in the groups ArVIII, ArIX, and ArX represents hydrogen atom or a linear or branched saturated alkyl group having 1 to 4 carbon atoms; and the substituent X 12 in the groups ArIX and ArX represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms, or carboxyl group; and the group Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, a —(CH 2 ) m N(R 18 )(R 19 ) group, or a —C(R 20 ) 2 OC(O)A 3 R 21 group, wherein m represents an integer of 2 or 3, R 18 is the same as R 19 , or represents a saturated alkyl group binding to R 19 to form a 3- to 6-membered ring together with the nitrogen atom or forms morpholino group together with the nitrogen atom, R 19 represents methyl group, ethyl group, or propyl group, R 20 represents hydrogen atom, methyl group, ethyl group, or propyl group, R 21 represents a lower alkyl group having 1 to 4 carbon atoms, a saturated cyclic alkyl group having 3 to 6 carbon atoms, or phenyl group, and A 3 represents a single bond or oxygen atom.