Patent ID: 9061004
Filing Date: 2015-06-23
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of treating a non-steroidal anti-inflammatory drug (NSAID)-responsive condition in a human subject, wherein the NSAID-responsive condition is selected from the group consisting of: an inflammatory disorder, an immunologic disorder, and colon neoplasia, and wherein the subject has been determined to have increased or decreased levels of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the method comprising: (i) administering to the subject an effective amount of an NSAID if the levels of 15-PGDH are increased; or (ii) administering to the subject an effective amount of an NSAID and an agent that upregulates 15-PGDH, wherein the agent is not a Prox-1 suppressor, if the levels of 15-PGDH are decreased.