Patent ID: 6303628
Filing Date: 2001-10-16
Classification: A61P,C07D

Abstract:
A compound of the following formula: ##STR19##or a pharmaceutically acceptable salt thereof whereinA is C.sub.1-6 alkylene or --NR.sup.1 --;Z is C(.dbd.L)R.sup.2, or SO.sub.2 R.sup.3 ;U is CH or N;W and Y are independently selected from --CH.sub.2 --, O, S and --N--R.sup.1 ;m is 1, 2 or 3;q and r are independently 0, 1 or 2;X is independently selected from halogen, C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, hydroxy, C.sub.1-4 alkoxy, halo-substituted C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, nitro, amino, mono- or di-(C.sub.1-4 alkyl)amino and cyano;n is 0, 1, 2, 3 or 4;L is oxygen or sulfur;R.sup.1 is hydrogen or C.sub.1-4 alkyl;R.sup.2 is hydroxy, C.sub.1-6 alkyl, halo-substituted C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo-substituted C.sub.1-6 alkoxy, C.sub.3-7 cycloalkoxy, C.sub.1-4 alkyl(C.sub.3-7 cycloalkoxy), --NR.sup.4 R.sup.5, C.sub.1-4 alkylphenyl-O-- or phenyl-O--, said phenyl being optionally substituted with one to five substituents independently selected from halogen, C.sub.1-4 alkyl, hydroxy, C.sub.1-4 alkoxy and nitro;R.sup.3 is C.sub.1-6 alkyl or halo-substituted C.sub.1-6 alkyl; andR.sup.4 and R.sup.5 are independently selected from hydrogen, C.sub.1-6 alkyl and halo-substituted C.sub.1-6 alkyl.