Patent ID: 6537993
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, whereinn is an integer from 1 to 6; R1 is H, alkyl (C1-C15), cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, halogen, haloalkyl, â€”OH, alkoxy, hydroxyalkyl, alkanoyl, â€”CONH2, â€”CONH(C1-C6 alkyl), â€”CON(C1-C6 alkyl)(C1-C6 alkyl), â€”CF3, â€”OCF3, â€”NH2, â€”CO2R8, â€”OC(O)R8, mono- or dialkylamino, aminoalkyl, or mono- or dialkylaminoalkyl; R3 is H, alkyl (C1-C15), cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, halogen, haloalkyl, â€”OH, alkoxy, hydroxyalkyl, alkanoyl, â€”CONH2, â€”CONH(C1-C6 alkyl), â€”CON(C1-C6 alkyl)(C1-C6 alkyl), â€”CF3, â€”OCF3, â€”NO2, â€”NH2, â€”CO2R8, â€”OC(O)R8, mono- or dialkylamino, aminoalkyl, or mono- or dialkylaminoalkyl; wherein each of the above is optionally substituted with up to 5 groups that are independently alkyl (C1-C6), halogen, haloalkyl, â€”CF3, â€”OCF3, â€”OH, alkoxy, hydroxyalkyl, or â€”NRâ€²Râ€³, wherein Râ€² and Râ€³ are independently H or alkyl (C1-C6); R2 is H, alkyl (C1-C8), cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, halogen, haloalkyl, â€”OH, alkoxy, hydroxyalkyl, alkanoyl, â€”CONH2, â€”CONH(C1-C6 alkyl), â€”CON(C1-C6 alkyl)(C1-C6 alkyl), â€”CO2R8, â€”OC(O)R8, â€”OC(O)NH2, â€”OC(O)NH(C1-C6 alkyl), â€”OC(O)N(C1-C6 alkyl) (C1-C6 alkyl), mono- or dialkylamino, aminoalkyl, or mono- or dialkylaminoalkyl; wherein each of the above is optionally substituted with up to 5 groups that are independently alkyl (C1-C6), halogen, haloalkyl, â€”CF3, â€”OCF3, â€”OH, alkoxy, hydroxyalkyl, â€”CN, or â€”NRâ€²Râ€³, wherein Râ€² and Râ€³ are independently H or alkyl (C1-C6); and R8 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; wherein each of the above is optionally substituted with up to 5 groups that are independently alkyl (C1-C6), alkoxy (C1-C6), halogen, â€”CF3, â€”OCF3, â€”OH, hydroxyalkyl, â€”CN, â€”CO2H, or â€”NRâ€²Râ€³, wherein Râ€² and Râ€³ are independently H or alkyl (C1-C6).