Patent ID: 6043368
Filing Date: 2000-03-28
Classification: C07D

Abstract:
A process for preparing thieno[3,2-c]pyridine derivatives of formula I: ##STR11## wherein: R.sub.1, is selected from the group consisting of lower alkyl; lower alkylene phenyl; substituted lower alkylene phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro and halo; lower alkylene naphthyl, lower alkylene thienyl; lower alkylene diphenyl; lower alkylene-hydroxy-phenyl; substituted lower alkylene-hydroxy-phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro, and halo; lower alkylene-hydroxy-naphthyl; lower alkylene-hydroxythienyl; lower alkylene-hydroxy-diphenyl, andR.sub.2 is H or lower alkyl,or a pharmaceutically acceptable salt thereof;said process comprising:(a) reacting a compound of a formula II: ##STR12## with a cyclic dioxy or a cyclic dithio in the presence of catalyst at an elevated temperature, thereby forming a reaction mixture; and(b) inducing said thieno[3,2-c]pyridine derivatives to crystallize directly from said reaction mixture, said thieno[3,2-c]pyridine derivatives being produced in 82% yield or greater when cyclic dioxy is employed.