Patent ID: 8993729
Filing Date: 2015-03-31
Classification: A01K,C07K,C12N

Abstract:
1. A composition comprising fully human monoclonal antibodies free of fucosyl residues and present in the egg white of an egg laid by a chicken at a concentration of at least 40 μg/ml, wherein said antibodies are encoded by an exogenous polynucleotide stably integrated in the genome of the chicken by homologous recombination and selectively expressed in tubular gland cells of said chicken, wherein the exogenous polynucleotide is operatively linked to a regulatory sequence of a gene encoding ovalbumin in its 5′ and 3′ ends, and wherein the 5′ regulatory sequence comprises at least 15 kb of the ovalbumin promoter regulatory sequence and the 3′ regulatory sequence comprises at least 15 kb of 3′ regulatory sequence of the ovalbumin gene.