Patent ID: 7659256
Filing Date: 2010-02-09
Classification: A61K

Abstract:
1. A method for effecting weight loss in a subject comprising administering to the subject a combination of: (a) a therapeutically effective amount of phentermine, and (b) a therapeutically effective amount of an anticonvulsant sulfamate derivative having the structure of formula I wherein X is CH 2 or O, R 1 , R 2 , R 3 , R 4 , and R 5 are independently H or C 1 -C 4 alkyl, and further wherein when X is O, then R 2 and R 3 , and/or R 4 and R 5 , may be taken together to form a methylene dioxy linkage of the formula —O—CR 6 R 7 —O— in which R 6 and R 7 are independently H or C 1 -C 3 alkyl, or may be taken together to form a cyclopentyl or cyclohexyl ring.