Patent ID: 6413965
Filing Date: 2002-07-02
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and a selective COX-2 inhibitor of formula I, wherein R1 is sulfamyl;R2 is haloalkyl; R3 is selected from hydrido and alkyl; and R4 is selected from aryl, cycloalkyl and cycloalkenyl; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, amido, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylsulfamyl, amino, N-alkylamino, N,N-dialkylamino, heterocyclic, nitro and acylamino, or a prodrug thereof or a pharmaceutically acceptable salt of said selective COX-2 inhibitor of formula I or of said prodrug.