Patent ID: 7365212
Filing Date: 2008-04-29
Classification: C07F

Abstract:
1. A process for in situ preparation of a chiral compound from an oxazaborolidine-borane complex, comprising the following steps: 1) adding to a suspension of a metal borohydride defined by formula (I): in which: M a metal ion is selected from the group consisting of sodium, potassium, lithium, and zinc: a) a Lewis base of general formula (II) below: in which: R n is equal to 1 or 2; and A is an atom selected from the group consisting of a nitrogen, oxygen, sulfur and phosphorus; and b) an inorganic acid ester of general formula (III) below: in which: X is selected from the group consisting of a sulfonyloxy ester group (—OS(O) R R 2) and then, adding to the product obtained after step 1 an optically active amino alcohol of general formula (IV) below: in which: R R R n is equal to 0, 1, 2 or 3; and at least one of C