Patent ID: 7902348
Filing Date: 2011-03-08
Classification: A61K,C07K,C12N

Abstract:
1. An isolated polynucleotide encoding human JAK-3 protein, said JAK-3 protein being a protein tyrosine kinase that includes an amino acid sequence Gly-Cys-Glu-Thr-His-Ala-Phe-Thr-Ala-His-Pro-Glu-Gly-Lys-His-His-Ser-Leu-Ser-Phe-Ser (amino acids 1104-1124 of SEQ ID NO:9), said JAK-3 protein having a molecular weight of approximately 125 kDa measurable by SDS polyacrylamide gel electrophoresis in an 8% polyacrylamide gel and Western blotting using an antibody specific for said amino acid sequence, that has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not substantially in resting T cells.