Patent ID: 8362218
Filing Date: 2013-01-29
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated peptide comprising Granulin/epithelin precursor (GEP) granulin units F (amino acids 126-178 of SEQ ID NO: 1), A (amino acids 284-335 of SEQ ID NO: 1), and C (amino acids 366-416 of SEQ ID NO: 1); and GEP linker units P3 (amino acids 179-205 of SEQ ID NO:1), P4 (amino acids 262-283 of SEQ ID NO:1), and P5 (amino acids 336-365 of SEQ ID NO:1), wherein the peptide antagonizes TNFR1 or TNFR2 signaling, and wherein the peptide is a mixed portion of the full-length GEP sequence.