Patent ID: 6413962
Filing Date: 2002-07-02
Classification: A61K,C07D

Abstract:
A method for treating a mammal to place the mammal under anesthesia, the method comprising administering a unit dosage amount of a guanidino compound to produce anesthesia, wherein the guanidino compound is lipophilic and thus capable of crossing the blood/central nervous system barrier; the compound having the structure selected from one of the following formulae: wherein B is a lipophilic aromatic group having a substituted phenyl group as shown in the above formulae; R, Râ€², Râ€³ and R* can each, independent of the others, be selected from the group consisting of hydrogen, halogen, trifluoromethyl, C1-C4 alkyl, oxyalkyl, alkynyl and alkenyl, hydroxyl, phenyl and condensed phenyl, phenoxy, naphthoxy, and substituted such aryl and aryloxy groups, and any two of Râ€², Râ€³ and R* can form an hydrocarbyl bridge, and wherein n is zero or an integer of from 1 to 2; nâ€² is an integer of from 1 to 3; Z, X1, X2, Y1 and Y2 can be the same or different and are selected from the group consisting of hydrogen, halogen, C1-C4-trifluoroalkyl, alkyl, and oxyalkyl, hydroxyl, phenyl, condensed phenyl, phenoxy, naphthoxy, and substituted aryl and aryloxy groups; at least one of X1 and Y1 being other than hydrogen; and their physiologically acceptable salts.