Patent ID: 6604698
Filing Date: 2003-08-12
Classification: A61K,B02C,Y10S

Abstract:
A process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of:(a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) continuously removing or separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein: the exit screen or separator comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a size distribution S2 which are smaller than S0; the very small milled substrate particles have a size distribution S3 and are smaller than all of the small media; and the large size media and the small size media are retained in the milling chamber.