Patent ID: 8685432
Filing Date: 2014-04-01
Classification: A61K,A61L,A61P

Abstract:
1. A bone graft combination biomaterial comprising: a. a biocompatible, osteoconductive, porous substrate, wherein the substrate comprises a material selected from the group consisting of an allograft bone and an alloplastic material, wherein the substrate is devoid of collagen and wherein the substrate comprises in its pores demineralized bone matrix and a first antimicrobial agent; and b. a film coating on the substrate surface, the coating comprising a degradable rate controlling polymer, wherein said polymer is polycaprolactone having a molecular weight from about 10 kD to about 200 kD , admixed with at least one second antimicrobial agent microencapsulated in microspheres or nanoencapsulated in nanospheres, wherein the first antimicrobial agent and the second antimicrobial agent can be the same or different, and wherein the polycaprolactone has a structure and a molecular weight selected to degrade over a time period of about six weeks when implanted within a subject and thereby release the agent over the time period.