Patent ID: 6107461
Filing Date: 2000-08-22
Classification: A61K,A61P,C07K

Abstract:
A multimenric antiviral agent comprising two or more monomers, wherein said monomers may be the same or different and are each independently selected from the group consisting of monomeric transmembrane intercellular adhesion molecule-1 (tmICAM-1) and monomeric fragments of tmICAM-1, with the proviso that said monomers must comprise domains I and II of ICAM-1 and with the proviso that when said multimeric antiviral agent is a dimer, the monomers cannot both be tmICAM-1, wherein said multimeric antiviral agent binds to a virus that binds to the human rhinovirus (HRV) binding site on ICAM-1 and reduces infectivity thereof, and wherein at least two of said monomers are oriented so that relative to each other they mimic the multimeric configuration of native tmICAM-1, such that said multimeric antiviral agent exhibits enhanced binding to said virus relative to at least one of its constituent monomers.