Patent ID: 6479495
Filing Date: 2002-11-12
Classification: C07C,C07D

Abstract:
A compound of the formula wherein:R1 is a group of the formula CH2Câ‰¡Câ€”R9; R2 is hydrogen, loweralkyl, a group of the formula CONR6R7, a group of the formula SO2R10, a group of the formula â€ƒor a group of the formula Si(R11)3; R3 is hydrogen or loweralkyl; R4 and R5 taken together with the nitrogen atom to which they are attached form a group of the formula R6 is hydrogen or loweralkyl; R7 is alkyl of 1 and 10 carbon atoms hydrogen or loweralkyl, a group of the formula â€ƒa group of the formula â€ƒor a group of the formula or R6 and R7 taken together with the nitrogen atom to which they are attached form a group of the formula R9 is hydrogen, a group of the formula C(R14R14â€²)OH, a group of the formula â€ƒor a group of the formula R10 is loweralkyl; R11 is loweralkyl; R12 is loweralkyl, hydroxyloweralkyl, a group of the formula COR15, a group of the formula â€ƒa group of the formula â€ƒa group of the formula â€ƒor a group of the formula R13 is hydrogen or loweralkyl; R14 is hydrogen or loweralkyl; R14 is hydrogen or loweralkyl; R15 is a group of the formula â€ƒor loweralkyl; R20 is loweralkyl; X is hydrogen or halogen; Z is hydrogen, halogen, loweralkyl, hydroxyl, loweralkoxy, trifluoromethyl, nitro or cyano; R20 CO, or a group of the formula OCONR6R7; m is 1 or 2; n is 0 or 1; p is 1 or 2; the optical isomers thereof; or the pharmaceutically acceptable salts thereof.