Patent ID: 6841371
Filing Date: 2005-01-11
Classification: A61K,A61P,C12N,C12Y,Y10S

Abstract:
1. A human protein C derivative having, in its activated form, anticoagulating activity and resistance to inactivation by serpin, wherein said derivative comprises SEQ ID NO: 1 having an amino acid substitution for Leu at position 194 with an amino acid selected from the group consisting of Ser, Ala, Thr, His, Lys, Arg, Asn, Asp, Glu, Gly, and Gln, and having at least one additional amino acid substitution selected from the group consisting of: His at position 10 is substituted with Gln; Ser at position 11 is substituted with Gly; Ser at position 12 is substituted with Lys; Gln at position 32 is substituted with Glu; Asn at position 33 is substituted with Asp or Phe; and the amino acid at position 195, 228, 249, 254, 302, or 316 is substituted with an amino acid selected from the group consisting of Ser, Ala, Thr, His, Lys, Leu, Mg, Asn, Asp, Glu, Gly, and Gln.