Patent ID: 7517986
Filing Date: 2009-04-14
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein Ra is —C(O)R1, —C(O)OR2, —C(O)SR2, —C(O)N(R3)R4, —S(O) Rb is optionally substituted by Rca and/or Rcb, and is Har, or Rb is Cyc, or Rb is chromenyl; in which R1, R2 and R3 may be the same or different and are independently selected from the group consisting of: hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, Ar, Har and Het, wherein each of said 1-7C-alkyl, 3-7C-cycloalkyl, Ar, Har and Het can be unsubstituted or substituted by at least one substituent independently selected from R5; each R4 is independently selected from the group consisting of: hydrogen, 1-7C-alkyl, and 3-7C-cycloalkyl, wherein each of said 1-7C-alkyl and 3-7C-cycloalkyl can be unsubstituted or substituted by at least one substituent independently selected from R5; R5, R11 Rca and Rcb may be the same or different and are independently selected from the group consisting of: R6, R7 and R8 may be the same or different and are independently selected from the group consisting of: hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, Ar, Har and Het, wherein each of said 1-7C-alkyl, 3-7C-cycloalkyl, Ar, Har and Het can be unsubstituted or substituted by at least one substituent independently selected from R12; each R9 is independently selected from the group consisting of: hydrogen, 1-7C-alkyl, and 3-7C-cycloalkyl, wherein each of said 1-7C-alkyl and 3-7C-cycloalkyl can be unsubstituted or substituted by at least one substituent independently selected from R12; each R10 is independently selected from the group consisting of: hydrogen, 1-7C-alkyl, and 3-7C-cycloalkyl; each R12 is independently selected from the group consisting of: R5; each Ar is independently selected from the group consisting of phenyl and naphthyl; each Har is independently a fully aromatic or partially aromatic mono- or fused bicyclic ring or ring system made up of a first constituent being a 5- or 6-membered monocyclic unsaturated, aromatic heteroaryl ring A, and, optionally, fused to said first constituent, a second constituent being a benzo group, any 3-7C-cycloalkane group, an additional heteroaryl ring A, or any heterocyclic ring B, wherein said Har ring or ring system is attached to the parent molecular group via a substitutable ring carbon or ring nitrogen atom; each Het is independently a fully saturated or partially unsaturated mono- or fused bicyclic ring or ring system made up of a first constituent being a 3- or 7-membered monocyclic fully saturated or partially unsaturated, non-aromatic heterocyclic ring B, and, optionally, fused to said first constituent, a second constituent being a benzo group, any 3-7C-cycloalkane group, or an additional heterocyclic ring B, wherein said Het ring or ring system is attached to the parent molecular group via a substitutable ring carbon or ring nitrogen atom; Cyc is a group of formula W  in which G is optionally substituted by Rda and/or Rdb on a ring carbon atom, and is a 5- or 6-membered saturated heterocyclic ring comprising one or two heteroatoms independently selected from the group consisting of —N(Rdc)—, oxygen and sulfur, in which Rda is 1-4C-alkyl, or halogen, Rdb is 1-4C-alkyl, or halogen, each Rdc is independently selected from the group consisting of: hydrogen, 1-4C-alkyl, and 1-4C-alkylcarbonyl, wherein said Cyc ring system is attached to the parent molecular group via a substitutable benzoring carbon atom; or a salt thereof.