Patent ID: 6413974
Filing Date: 2002-07-02
Classification: A61P,C07D

Abstract:
A compound of the formula wherein R is selected from the group consisting of R2, R2NHâ€”, or H2Nâ€”R3â€”, where R2 is selected from the group consisting of C1-C8 alkyl and Z is selected from the group consisting of phenyl, heterocycle and cycloalkyl, wherein the heterocycle is selected from the group consisting of piperidinyl, pyridinyl, isoxazolyl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperazinyl, benzimidazolyl, thiazolyl, thiophenyl, furanyl, indolyl, 1,3-benzodioxolyl, tetrahydropyranyl, imidazolyl, tetrahydrothiophenyl, pyranyl, dioxanyl, pyrrolyl, pyrimidinyl, pyrazinyl, triazinyl, oxazolyl, purinyl, quinolinyl, and isoquinolinyl; each R4 is independently hydrogen or C1-C4 alkyl, and n is an integer 1-8; wherein each C1-C8 alkyl and Z is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of Hal, OH, and C1-C4 alkyl; R3 is C1-C8 alkylene; and R1 is selected from the group consisting of cyclopentyl and isopropyl, and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof.