Patent ID: 8710188
Filing Date: 2014-04-29
Classification: A61K,C07K,C12N,C12Q,C12Y,G01N

Abstract:
1. A method for determining the structure of a complex comprising a compound and a peptide bound to factor IXa protein, wherein said factor IXa is selected from the group consisting of SEQ ID NO: 14 and 18, said peptide comprises SEQ ID NO: 13 and said compound is selected from the group consisting of: said method comprising: (a) mixing the factor IXa protein with the compound; (b) crystallizing said factor IXa protein-compound complex; and (c) determining the three-dimensional structure of the complex which results in atomic coordinate data of any one of Tables 2-6 optionally varied by a root mean square deviation of conserved residue backbone atoms or of alpha carbon atoms of less than about 1.5 Å when superimposed on backbone atoms described in Table 2, 3, 4, 5 or 6, and wherein the resultant crystal of part (b) forms in one of in the following crystalline space groups and unit cell parameters: