Patent ID: 7914766
Filing Date: 2011-03-29
Classification: B01J

Abstract:
1. A radionuclide generator system for radiochemical separation of daughter radionuclides from a solution of parental radionuclides, the generator system comprising: a resin material comprising a silica-based cation-exchanger structure having at least one ligand covalently attached to the surface of said silica-based structure wherein each ligand covalently attached to the surface of said silica-based structure comprises a silane group having desirable surface functionality to enable the covalent attachment of said ligand thereon said surface of said structure, each ligand covalently attached to the surface of said silica-based structure further comprises a second chemical group capable of binding and holding said parental radionuclides on said resin material while allowing said daughter radionuclides to elute off said resin material, wherein each ligand covalently attached to the surface of said silica-based structure has a carbon chain with 4 or less carbons to maintain radiation stability of said resin material, wherein said silica-based structure of said resin material is selected from the group consisting of monolith sol-gels, templated mesoporous sol-gels, and nonporous silica gels, wherein the generator system is capable of providing clinical quantities of the daughter radionuclides of at least 20-mCi.