Patent ID: 8557929
Filing Date: 2013-10-15
Classification: C08L

Abstract:
1. A method for producing a biodegradable polyoxyalkylene derivative, which comprises: reacting a biodegradable polyoxyalkylene compound represented by the following formula (1): wherein Z represents a residue of a compound having from 2 to 10 hydroxyl groups; Y represents a single bond or a group selected from the group consisting of an alkylene group having from 1 to 6 carbon atoms, —C(═O)—, —C(═O)O—, —C(═O)(CH X represents a group selected from the group consisting of a carboxyl group, a maleimide group, a t-butoxycarbonylamino group and a 3,3-diethoxypropoxy group; R represents a hydrocarbon group having from 1 to 6 carbon atoms; AO represents an oxyalkylene group having from 2 to 4 carbon atoms; a is from 1 to 500, and b is from 0 to 500; m1 and m2 are each independently from 5 to 2000; m3 is from 0 to 2000; n1 is from 1 to 5, and n2 is from 0 to 1; and k1 is from 0 to 8, k2 is from 0 to 8 and k3 is from 1 to 10, k1, k2 and k3 satisfy a relationship, 2≦k1+k2+k3≦10; with a compound represented by the following formula (I-1) in the presence of potassium carbonate; wherein t is from 1 to 2; the biodegradable polyoxyalkylene derivative being represented by the following formula (2): wherein Z represents a residue of a compound having from 2 to 10 hydroxyl groups; Y represents a single bond or a group selected from the group consisting of an alkylene group having from 1 to 6 carbon atoms, —C(═O)—, —C(═O)O—, —C(═O)(CH X represents a group selected from the group consisting of a carboxyl group, a maleimide group, a t-butoxycarbonylamino group and a 3,3-diethoxypropoxy group; R represents a hydrocarbon group having from 1 to 6 carbon atoms; AO represents an oxyalkylene group having from 2 to 4 carbon atoms; a is from 1 to 500, and b is from 0 to 500; m1 and m2 are each independently from 5 to 2000; m3 is from 0 to 2000; n1 is from 1 to 5, and n2 is from 0 to 1; and k1 is from 0 to 8, k2 is from 0 to 8 and k3 is from 1 to 10, k1, k2 and k3 satisfy a relationship, 2≦k1+k2+k3≦10; and G represents a residue originating in a compound represented by the formula (I-1), provided that in a case where k3 is 2 or more, at least one G may be a hydrogen atom.