Patent ID: 7932416
Filing Date: 2011-04-26
Classification: C07C

Abstract:
1. A process for preparing an ortho-substituted pentafluorosulfanylbenzene of Formula (I): comprising reacting a pentafluorosulfanylbenzene with an electrophile under electrophilic aromatic substitution conditions selected from halogenation chlorosulfonation, sulfonation and nitration to effect substitution on the position ortho to said pentafluorosulfanyl on the benzene ring wherein: R1 is: Cl, Br, I, —SO R2 and R4 are, each independently, hydrogen, F, Cl, Br, I, —CN, NR9R10, —OR11, —SR12, —COR13, —(SO R3 is hydrogen, F, Cl, Br, I, —CN,—NO R5 is: (a) hydrogen, F, Cl, Br, I, —CN, —SO optionally converting the compound of Formula (I) into a pharmaceutically acceptable salt.