Patent ID: 7396809
Filing Date: 2008-07-08
Classification: A01K,A61K,A61P,G01N

Abstract:
1. A method for inducing or enhancing the glucose-responsiveness of a pancreatic cell, which pancreatic cell has impaired cell function and which cell function is glucose-responsiveness, comprising administering to said pancreatic cell an amount of a PYY agonist or a biologically active fragment thereof, wherein said PYY agonist comprises the amino acid sequence having a sequence identical to the peptide encoded by the nucleic acid sequence wherein the nucleic acid sequence hybridizes under stringent conditions, including a wash step of 0.2×SSC at 65° C., to SEQ ID NO: 1, wherein the amount of said PYY agonist or biologically active fragment thereof is sufficient to induce or enhance the glucose-responsiveness of said pancreatic cell, and wherein said PYY agonist or biologically active fragment thereof binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.