Patent ID: 6090794
Filing Date: 2000-07-18
Classification: A61K

Abstract:
A method for inhibiting both angiogenesis and the growth of a human neurofibrosarcoma substantially associated with neurofibromatosis in a mammal comprising administering to said mammal and effective amount of a combination ofA. heparin orB. a heparin fragment selected from the group consisting of hexasaccharide pentasaccharide fragments orC. a synthetic heparin substitute selected from the group consisting tetrapropoxy-.beta.-cyclodextrin, tetradecamethoxy-.beta.-cyclodextrin, .beta.-cyclodextrin heptasulfate, .beta.-cyclodextrin tetradecasulfate, .alpha.-cyclodextrin dodecasulfate, and .gamma.-cyclodextrin hexadecasulfatetogether withD. an angiostatic steroid selected from the group consisting of hydrocortisone, 11.alpha.-epihydrocortisol, cortexolone, 17.alpha.-hydroxyprogesterone, corticosterone, desoxycorticosterone, testosterone, estrone, dexamethasone, triamcinolone, and 6.alpha.-fluoro-17,21 -dihydroxy-16.beta.-methyl-pregna-4,9(11)-diene-3,20-dione orE. a dihydro or tetrahydro angiostatic steroid derivative.