Patent ID: 6946130
Filing Date: 2005-09-20
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating conditions associated with excess eosinophil production selected from the group consisting of chronic eosinophilic pneumonia, allergic bronchopulmonary aspergillosis, coeliac disease, eosinophilic gastroenteritis, Churg-Strauss syndrome, eosinophilic myalgia syndrome, hypereosinophilic syndrome, and oedematous reactions, in a human, comprising the step of administering to said human in need thereof an effective amount of a synthetic antibody comprising a heavy chain and a light chain, wherein the framework regions of said heavy and light chains are obtained from at least a first antibody and the amino acid sequences of the complementarity determining regions of the heavy chain comprise in sequential order: 1) CDR 1, comprising the amino acid sequence identified as SEQ ID NO: 7; 2) CDR 2 comprising the amino acid sequence identified as SEQ ID NO: 8, and; 3) CDR 3 comprising the amino acid sequence selected from the group consisting of (A) SEQ ID NO: 9 and (B)SEQ ID NO: 14.