Patent ID: 8641974
Filing Date: 2014-02-04
Classification: G01N,G01R

Abstract:
1. A device for dynamic detection and selection of magnetically labeled cells, comprising: a microfluidic channel; and a Wheatstone bridge circuit with at least one magnetoresistive element, the Wheatstone bridge circuit being provided in a vicinity of the microfluidic channel such that the microfluidic channel runs along the Wheatstone bridge circuit and such that magnetically labeled cells flowing through the microfluidic channel measurably influence a balance of the Wheatstone bridge circuit wherein the device has at least two bridge elements disposed outside a detection region of the microfluidic channel such that: two bridge elements are disposed outside the detection region of the microfluidic channel and two bridge elements are disposed inside the detection region of the microfluidic channel, diagonal elements of the Wheatstone bridge circuit are formed by two bridge elements disposed outside the detection region of the microfluidic channel, the bridge elements of the Wheatstone bridge circuit are spaced apart by at least the size of the cells, and a distance between the two bridge elements disposed inside the detection region of the microfluidic channel is greater than a distance between the two bridge element disposed outside the detection region of the microfluidic channel, wherein the device comprises means for obtaining additional information about the magnetically labeled particles by determining different magnetization relaxation times by time-resolved measurements using a magnetorresistive sensor.