Patent ID: 6348477
Filing Date: 2002-02-19
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R is selected from the group consisting of hydrogen, lower alkyl, amino, lower alkylamino, di(lower alkyl)amino, lower alkanoylamino, (lower alkoxycarbonyl)amino, di(lower alkoxycarbonyl)amino, {(lower alkylamino)carbonyl}amino and pyridinylamino; and Z is selected from the group consisting of: (iii) C(O)â€”NR2BR3B wherein: R2B is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, phenyl(lower alkyl), phenyl(lower alkyl) monosubstituted or disubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy, lower alkyl or trifluoromethoxy; lower cycloalkyl, (lower cycloalkyl)-(lower alkyl) or {1-hydroxy-(lower cycloalkyl}-(lower alkyl) or (Het)-(lower alkyl) wherein Het is pyridinyl and R3B is: wherein R4B is hydrogen, lower alkyl, phenyl(lower alkyl), phenyl(lower alkyl) monosubstituted or disubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy, lower alkyl or trifluoromethoxy; (lower cycloalkyl)-(lower alkyl) or (Het)-(lower alkyl) wherein Het is as defined in this claim; R5B has the same significance as R2B in this claim and R6B has the same significance as R3B in this claim wherein at least one of R5B or R6B must be (Het)-(lower alkyl) and wherein Het is pyridinyl or a therapeutically acceptable acid addition salt thereof.