Patent ID: 6604052
Filing Date: 2003-08-05
Classification: G06K,G06T,Y10S

Abstract:
A method of determining the three-dimensional structure of a particle, said method comprising:(a) obtaining a plurality of labeled particle images, wherein each particle image of said plurality is obtained by: (i) rigidly attaching at least four heavy atom clusters to said particle so that translational movement of each rigidly attached cluster does not exceed about 4 Ã¥; and (ii) imaging said particle to obtain a labeled particle image; and (b) deriving the three-dimensional structure of said particle from said plurality of particle images, wherein said deriving comprises aligning each of said labeled particle images by deriving the orientation of each of said labeled particle images from the three-dimensional coordinates of said at least four rigidly attached clusters and the cluster projections in each of said labeled particle images to determine the three-dimensional structure of said particle.