Patent ID: 6500841
Filing Date: 2002-12-31
Classification: A61P,C07D

Abstract:
A compound having the formula I: or a pharmaceutically acceptable salt or disulfide thereof;wherein:R1 and R2 are independently selected from H and C1-4 alkyl; R3 and R4 are independently selected from: H; C1-8 alkyl, alkenyl, alkynyl, or â€ƒunsubstituted or substituted with one or more of: 1) aryl or heterocycle, unsubstituted or substituted with: a) C1-4 alkyl, b) (CH2)tOR6, c) (CH2)tNR6R7, d) halogen, 2) C3-6 cycloalkyl, 3) OR6, 4) SR6, S(O)R6, SO2R6, R5 is hydrogen; R6, R7 and R8 are independently selected from: H; C1-4 alkyl, C3-6 cycloalkyl, heterocycle, aryl, unsubstituted or substituted with: a) C1-4 alkoxy, b) aryl or heterocycle, c) halogen, d) HO, â€ƒwherein R6 and R7 may be joined in a ring, and R7 and R8 may be joined in a ring; R9 is C1-4 alkyl or aralkyl; m is 0, 1 or 2; t is 1 to 4; X is H2; and Y is substituted or unsubstituted ring system selected from the following â€ƒand wherein the substituent is selected from C1-4 alkyl, C3-6 cycloalkyl, heterocycle, aryl, said substituent which is unsubstituted or substituted with: a) C1-4 alkoxy, b) aryl or heterocycle, c) halogen, d) HO,