Patent ID: 6548477
Filing Date: 2003-04-15
Classification: A61K,A61P,C07K,Y02A

Abstract:
A compound of Formula I, whereinA is a MetAP-2 inhibitory core; W is O or NR; each R is, independently, hydrogen or alkyl; Z is â€”C(O)â€” or -alkylene-C(O)â€”; P is NHR, OR or a peptide consisting of one to about one hundred amino acid residues connected at the N-terminus to Z; Q is a linear, branched or cyclic alkyl or aryl; or Z is -alkylene-Oâ€” or -alkylene-N(R)â€”; P is hydrogen or a peptide consisting of from one to about one hundred amino acid residues connected to Z at the carboxyl terminus, Q is a linear, branched or cyclic alkyl or aryl; and pharmaceutically acceptable salts thereof.