Patent ID: 7973023
Filing Date: 2011-07-05
Classification: A61K,A61P,C07C,C07F,Y02A

Abstract:
1. A method of treating an inflammation associated with an endogenous oxidized lipid, said inflammation being associated with a disease selected from the group consisting of psoriasis, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis, the method comprising administering to a subject in need thereof a therapeutically effective amount of at least one oxidized lipid having the general formula I: wherein: n is an integer of 1-6, whereas if n=1, Cn, Bn, Rn and Y are absent; each of B each of A Y is selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, carboxy, saccharide, phosphoric acid, phosphoryl choline, phosphoryl ethanolamine, phosphoryl serine, phosphoryl cardiolipin, phosphoryl inositol, ethylphosphocholine, phosphorylmethanol, phosphorylethanol, phosphorylpropanol, phosphorylbutanol, phosphorylethanolamine-N-lactose, phosphoethanolamine-N-[methoxy(propylene glycol)], phosphoinositol-4-phosphate, phosphoinositol-4,5-biphosphonate, pyrophosphate, phosphoethanolamine-diethylenetriamine-pentaacetate, dinitrophenyl-phosphoethanolamine and phosphoglycerol; and each of X wherein: m is an integer of 1-26; and Z is selected from the group consisting of: whereas W is selected from the group consisting of oxygen, sulfur, nitrogen and phosphorus, whereby each of said nitrogen and phosphorus is substituted by at least one substituent selected from the group consisting of hydrogen, lone pair electrons, alkyl, halo, cycloalkyl, aryl, hydroxy, thiohydroxy, alkoxy, aryloxy, thioaryloxy, thioalkoxy and oxo; and at least one of X each of R each of C a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvate thereof, thereby treating the inflammation associated with an endogenous oxidized lipid in said subject.