Patent ID: 6686443
Filing Date: 2004-02-03
Classification: B01J,C07K,C40B

Abstract:
A method of forming an intramolecular disulfide bond in a peptide, said method comprising:contacting a peptide comprising at least two sulfhydryl (SH) groups with a compound having the formula: wherein R1 and R2 are independently selected from the group consisting of Clâ€”, Brâ€”, Iâ€”, OHâ€”, and RCO2â€” where R is an alkyl or substituted alkyl; Pt is Pt(IV); X1, X2, X3, and X4 are ligands independently selected from the group consisting of a nitrogen ligand, an oxygen ligand, a phosphorous ligand, and a sulfur ligand; i, k, m, and p are independently 0 or 1; L1, L2, L3, and L4 when present, are independently selected linkers.