Patent ID: 6251913
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A compound of the formula (I): ##STR38##wherein:n is 1 to 6;Het is a nitrogen containing ring fused to the benzene ring on two adjacent carbon atoms to form a bicyclic ring system which ring system may be optionally substituted;R.sup.1 is hydrogen, C.sub.1-8 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, arylC.sub.1-6 alkyl, heteroarylC.sub.1-6 alkyl, heterocyclylC.sub.1-6 alkyl or C.sub.3-8 cycloalkylC.sub.1-6 alkyl;R.sup.2 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, arylC.sub.1-6 alkyl, heteroarylC.sub.1-6 alkyl or the side-chain of a naturally occurring amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.4-8 cycloalkenyl, arylC.sub.1-6 alkyl, heteroarylC.sub.1-6 alkyl or heterocyclylC.sub.1-6 alkyl;R.sup.4 is hydrogen or C.sub.1-6 alkyl; or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are joined form a heterocyclic ring;wherein any group or ring, in R.sup.1 -R.sup.4, is optionally substituted;or a pharmaceutically acceptable salt or in vivo hydroysable ester thereof.