Patent ID: 7867518
Filing Date: 2011-01-11
Classification: A61K,A61P

Abstract:
1. A method for the preparation of a pharmaceutical composition for controlled release comprising microparticles including a polymeric carrier and an interferon incorporated therein, wherein the initial release of the interferon within 4 hours is not more than about 10% of the incorporated interferon, wherein the polymeric carrier includes block copolymers constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT), comprising: (a) preparing an emulsion comprising (b) solidifying the polymeric carrier into microparticles by removing at least a fraction of the organic solvent from the emulsion prepared in step (a); and (c) collecting and drying the microparticles formed in step (b), wherein step (b) is carried out by emulsifying the emulsion prepared in step (a) in a coherent aqueous phase to obtain a w/o/w-double emulsion, wherein the coherent aqueous phase comprises an osmotic agent, wherein the osmolality of the coherent aqueous phase is higher than that of the aqueous inner phase.