Patent ID: 8197500
Filing Date: 2012-06-12
Classification: A61B

Abstract:
1. An aneurysm clip, comprising: a biological membrane that is a natural animal tissue isolated from its host and having a substrate that has: (i) been fixed with crosslinking reagents, (ii) residual specific active groups in protein molecules of the substrate that have been blocked by at least one active reagent after fixation by the crosslinking reagents, (iii) specific conformation of protein molecules of the substrate altered by a reagent with strong hydrogen bonding power, and (iv) an active layer coupled thereto, the active layer including either a polypeptide or a glucosaminoglycan that has the ability to adhere growth factors after implantation; a metal clip having: wherein the biological membrane is coupled to the first and second clip arms in a manner that defines a curved receiving portion.