Patent ID: 6869590
Filing Date: 2005-03-22
Classification: A61K

Abstract:
1. A compound of formula (I): wherein M is a radionuclide selected from: C wherein A E is a direct bond, CH, or a spacer group independently selected at each occurrence from the group: (C R R R R L wherein, W is independently selected at each occurrence from the group: O, S, NH, NHC(═O), C(═O)NH, NR aa is independently at each occurrence an amino acid; Z is selected from the group: aryl substituted with 0-3 R R R R R k is selected from 0, 1, and 2; h is selected from 0, 1, and 2; h′ is selected from 0, 1, and 2; g is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; g′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; s″ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; t is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; t′ is selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; x is selected from 0, 1, 2, 3, 4, and 5; x′ is selected from 0, 1, 2, 3, 4, and 5; n is an integer from 1 to 10; wherein L BM is an SR-A antagonist of formula: wherein R R m is an integer from 1 to 4; or a pharmaceutically acceptable salt thereof.