Patent ID: 7767695
Filing Date: 2010-08-03
Classification: A61K,C04B,C07D

Abstract:
1. A method for treating overweight or obesity, comprising: administering to a subject in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein m is 1, R 1 is C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, which may optionally be substituted with one or more substituents selected from halogen, C C 3-8 -cycloalkyl, C 5-8 -cycloalkenyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, di(C 3-8 -cycloalkyl)-C 1-6 -alkyl, C 3-8 -cycloalkyl-C 2-6 -alkenyl, C 3-8 -cycloalkyl-C 2-6 -alkynyl, C 5-8 -cycloalkenyl-C 1-6 -alkyl, C 5-8 -cycloalkenyl-C 2-6 -alkenyl, C 5-8 -cycloalkenyl-C 2-6 -alkynyl, wherein the cyclic moieties may optionally be substituted with one or more substituents selected from C R 2 is C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkyl-C 1-6 -alkyl, X is —CH 2 —(CH 2 ) n —, —(CH 2 ) n —CH═CH—(CH 2 ) p —, —CH 2 —(CH 2 ) n —O—(CH 2 ) p —, —CH 2 —(CH 2 ) n —C(═O)—(CH 2 ) p —, —CH 2 —(CH 2 ) n —S—(CH 2 ) p —, —CH 2 —(CH 2 ) n —S(═O)—(CH 2 ) p — or —CH 2 —(CH 2 ) n —S(═O) 2 —(CH 2 ) p —, n and p are independently 0, 1, 2, 3 or 4, R 3 and R 4 are independently hydrogen, methyl or trifluoromethyl, Y is (a) phenyl, naphthyl, pyridyl, benzoxazolyl or benzothiophenyl, which may optionally be substituted with one or more substituents selected from (b) C as well as any diastereomer or enantiomer or tautomeric form thereof, mixtures of these or a pharmaceutically acceptable salt thereof.