Patent ID: 7388095
Filing Date: 2008-06-17
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 together with the nitrogen atom to which they are attached form a 6-membered saturated or partly unsaturated heterocyclic ring optionally containing a further heteroatom or group selected from the group consisting of nitrogen, oxygen, sulphur, a sulfinyl group, and a sulfonyl group, wherein said heterocyclic ring is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of (1) lower alkyl, (2) halogen, (3) halogenoalkyl, (4) hydroxy, (5) lower hydroxyalkyl, (6) lower alkoxy, (7) oxo, (8) phenyl, (9) benzyl, (10) pyridyl and (11) carbamoyl, and wherein said heterocyclic ring is optionally condensed with a phenyl ring wherein said phenyl ring is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of lower alkyl, lower alkoxy and halogen; R 3 is selected from the group consisting of (1) hydrogen, (2) lower alkyl, (3) lower hydroxyalkyl, (4) lower alkoxyalkyl, (5) lower halogenoalkyl, (6) lower cycloalkylalkyl, (7) lower alkanoyl, (8) lower cyanoalkyl, (9) lower alkylsulfonyl, (10) phenylsulfonyl wherein the phenyl ring is unsubstituted or substituted with one or two substituents independently selected from the group consisting of lower alkyl, halogen, lower alkoxy lower halogenoalkoxy and lower hydroxyalkyl; (11) phenyl unsubstituted or substituted with one or two substituents independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower halogenoalkoxy and lower hydroxyalkyl; and (12) lower phenylalkyl, wherein the phenyl ring is unsubstituted or substituted with one or two substituents independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower halogenoalkoxy and lower hydroxyalkyl; R 4 hydrogen or halogen; G is selected from the group consisting of: wherein: R A is CH m is 0, 1 or 2; n is 0, 1 or 2; and R