Patent ID: 7078393
Filing Date: 2006-07-18
Classification: C07F

Abstract:
1. A method for preparing 1-hydroxy-1,1-diphosphonic acid compounds of the general formula I and/or of their pharmacologically compatible salts wherein R R Y O, S, or NH, Z C m and n are 0 or 1, under the condition that when n=1 then also m=1, a) reacting a compound of the formula II wherein R 1 , R 2 , Y, Z, m, and n are defined as above, with a compound of the formula III wherein R 5 is a C 1 –C 4 alkyl group; R 6 is a C 1 –C 6 alkoxy group; p is 0, 1, or 2; and b) hydrolyzing the reaction product of step a).