Patent ID: 8933110
Filing Date: 2015-01-13
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, L and B are taken together to form a linker selected from one of the groups illustrated below: W is selected from the group consisting of: G is: Q is X X R R R n is 1, 2, or 3; L L Y at each occurrence is independently C(O) or S(O) wherein -L R U is independently selected from C(R R R alternatively two geminal R R alternatively, CHR yet alternatively, U, R R wherein “heteroaryl” refers to a mono- or polycyclic aromatic radical having one or more ring atom selected from S, O and N; and the remaining ring atoms are carbon, wherein any N or S contained within the ring may be optionally oxidized; “heterocyclic” refers to a non-aromatic ring or a bi- or tri-cyclic group fused system, where (i) each ring system contains at least one heteroatom independently selected from oxygen, sulfur and nitrogen, (ii) each ring system can be saturated or unsaturated (iii) the nitrogen and sulfur heteroatoms may optionally be oxidized, (iv) the nitrogen heteroatom may optionally be quaternized, (v) any of the above rings may be fused to an aromatic ring, and (vi) the remaining ring atoms are carbon atoms which may be optionally oxo-substituted; and “substituted” refers to substitution by independent replacement of one, two, or three or more of the hydrogen atoms with substituents selected from —F, —Cl, —Br, —I, —OH, protected hydroxy, —NO