Patent ID: 8114647
Filing Date: 2012-02-14
Classification: A61K,A61L,B33Y,C12N

Abstract:
1. A method for delivering one or more biologically active molecules to a subject, comprising: providing one or more biologically active molecules; providing one or more devices with a semi-permeable component including a confluent tissue coating of blood brain barrier capillary endothelial cells; at least one structural component that is at least partially composed of porous bone that is in contact with and supports the semi-permeable component; the semi-permeable component substantially surrounds the at least one structural component; and an internal cavity that is substantially surrounded by the semi-permeable component and at least a portion of the porous bone; the one or more biologically active molecules included in the pores and/or the cavity of the one or more devices; and implanting in the subject one or more of the devices containing the biologically active molecules; wherein at least one characteristic of the blood brain barrier capillary endothelial cells is different from the at least one corresponding characteristic of peripheral capillary endothelial cells.