Patent ID: 6211198
Filing Date: 2001-04-03
Classification: C07D,C07F

Abstract:
A compound having the structure: ##STR282##wherein X is C.dbd.O, CH.sub.2, CR.sup.a.sub.2, NH, NR.sup.a, NCHO, NCOR.sup.a, NOH, O, or S;wherein R.sup.a is a methyl, ethyl, or propyl group;wherein Q is SH, SR""', NH.sub.2, NHR""', NR.sub.2 ""', NR""OH, NR""OR""', or a linear or branched chain alkyl group, or an arylalkyl group, or an alkenyl or alkynyl group, or an aryl group;wherein R"" is H, a linear or branched chain alkyl group, cyanoalkyl, or an aryl group;wherein R""' is a linear or branched chain alkyl group, or an aryl group;wherein R is H, a linear or branched chain alkyl or acyl group, or an aryl group;wherein R.sup.0 is H, methyl, ethyl, straight chained or branched propyl, an alkoxyalkyl, azidoalkyl, aminoalkoxyalkyl, azidoalkoxyalkyl, trihaloalkoxyalkyl, aminoalkyl, hydroxyalkyl or an aryl group, or (CH.sub.2).sub.t W;wherein R.sup.1 is H, a linear or branched chain alkyl, an alkoxyalkyl, azidoalkyl, aminoalkoxyalkyl, azidoalkoxyalkyl, trihaloalkoxyalkyl, aminoalkyl, hydroxyalkyl, or an aryl group, or (CH.sub.2).sub.t W;wherein W is NH.sub.2, NHR', NR.sub.2 ', NHOH, N.sup.+ R.sub.3 'Z.sup.-, NHCOR', N.sub.3, NO.sub.2 or CH.sub.2 W.sup.0 (CH.sub.2).sub.v W.sup.1, or a linear or branched chain alkyl group, or an arylalkyl group, or an alkenyl or alkynyl group, or an aryl group;wherein R' is a linear or branched chain alkyl group, or an aryl group;wherein W.sup.0 is O, S, or NH;wherein W.sup.1 is NH.sub.2, NHR', NR.sub.2 ', NHOH, N.sup.+ R.sub.3 'Z.sup.-, NHCOR', N.sub.3, or NO.sub.2 ;wherein Z.sup.- is a pharmaceutically acceptable counterion;wherein t is 1, 2, 3, 4, 5, or 6;wherein v is 2, 3, 4, 5, or 6;wherein R.sup.2, R.sup.13, and R.sup.14 are independently the same or different and are H, or a linear or branched chain alkyl, hydroxyalkyl, alkoxyalkyl, amino alkyl, or aryl group;wherein R.sup.4 is H, a linear or branched chain alkyl, alkoxyalkyl, hydroxyalkyl, or a linear or branched chain alkenylalkyl group;wherein R.sup.5 and R.sup.6 are independently the same or different and are H, OH, Cl, Br, I, F, NO.sub.2, CN, NH.sub.2, N.sub.3, CF.sub.3, a linear or branched chain alkyl, alkoxy, alkoxycarbonyl, acyl, alkylsulfoxide, or mono- or dialkylamino group, or together constitute a methylenedioxy group;wherein R.sup.7 and R.sup.8 are independently the same or different and are H, CN, CF.sub.3, OH, OR', OCOR', NH.sub.2, NHR', NR'.sub.2, NHCOR', CONH.sub.2, CONHR', CONR.sub.2 ', COOH, COOR', CHO, COR', COSH, COSR', COO(CH.sub.2).sub.q OH or COO(CH.sub.2).sub.q OR', or a benzyl group, a linear or branched chain alkyl or cycloalkyl group, or are a heteroaryl group consisting of a pyridyl, indolyl, indolylalkyl, quinolinyl, isoquinolinyl, pyrryl, furyl or thiophene group, or an aryl group having the structure: ##STR283##wherein R.sup.9 and R.sup.10 are independently the same or different and are H, Cl, Br, I, F, OH, NO.sub.2, N.sub.3, Or.sup.iv, OCOR.sup.iv, OCOOR.sup.iv, OCONHR.sup.iv, NH.sub.2, NHR.sup.iv, NR.sup.iv.sub.2, NHCOR.sup.iv, NHCOOR.sup.iv, or NHCONHR.sup.iv ;wherein R.sup.iv is a linear or branched chain alkyl group;wherein q is 2, 3, 4, or 5;wherein R.sup.12 is H or a linear chain alkyl group; andwherein n is 2, 3, or 4.