Patent ID: 6812237
Filing Date: 2004-11-02
Classification: A61K,C07C,C07D

Abstract:
A compound of the formula wherein R1 is aryl or biaryl;R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloakyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in which C2-C7-alkyl is interrupted by Y; Y is O, S, SO, SO2, CO or NR6; R3 is hydrogen or lower alkyl; or R2 and R3 combined are C2-C7-alkylene or C2-C7-alkylene interrupted by Y; R4 is hydrogen or lower alkyl; R5 represents the grouping â€”Xâ€”Arâ€”Qâ€”Z in which X is lower alkylene, lower alkyleneoxy or C2-C1-alkylene interrupted by Y; Ar is monocyclic carbocyclic or monocyclic heterocyclic arylene; Q is a direct bond, lower alkylene, or thio- or oxy-lower alkylene: Z is hydroxy, acyloxy, carboxyl, or carboxyl derivatized as a pharmaceutically acceptable ester or amide; or Z is 5-tetrazolyl; Y is O, S, SO, SO2 or NR6; and R6 is hydrogen, lower alkyl or aryl-lower alkyl; or a pharmaceutically acceptable salt thereof.