Patent ID: 8664193
Filing Date: 2014-03-04
Classification: A61P,C12N,C12Y

Abstract:
1. A double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises at least two sequences that are substantially complementary to each other and wherein a sense strand of the dsRNA comprises a first sequence and an antisense strand of the dsRNA comprises a second sequence comprising a region that is substantially complementary to at least part of an mRNA encoding Factor VII, wherein said region of complementarity is less than 30 nucleotides in length, and wherein said first sequence comprises at least 15 contiguous nucleotides of SEQ ID NO: 55 (CCUCUGCCUGCCCGAACGG), and wherein said second sequence comprises at least 15 contiguous nucleotides of SEQ ID NO:56 (CCGUUCGGGCAGGCAGAGG).