Patent ID: 8278467
Filing Date: 2012-10-02
Classification: C07B,C07C,C07D,Y02P

Abstract:
1. A process for the preparation of a compound of formula (7): wherein R is one of the following: and wherein R R R said process comprises: a) hydroxylating a compound of formula (1): wherein Y is a halo group, P b) oxidizing the compound of formula (2) to provide a compound of formula (3): c) coupling the compound of formula (3) with a compound of formula (4): wherein Z is (PR wherein when W is —OP 2 , removing at least a portion of the P 2 protecting group and oxidizing the compound of formula (5) to provide a compound of formula (6): and d) subjecting the compound of formula (5) when W is ═O, or the compound of formula (6) to ring-opening, removing at least a portion of the P 1 protecting group, and optionally removing at least a portion of additional protecting groups to provide a compound of formula (7).