Patent ID: 9151764
Filing Date: 2015-10-06
Classification: A61B,B01D,B01L,G01N,Y10T

Abstract:
1. An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region, the barrier layer comprising a semi-permeable membrane having a polymer which incorporates a negative charge within the pores of the membrane, the membrane being formed by generating the polymer in situ by diffusing a monomer incorporating a negative charge into the pores of a membrane and initiating polymerisation; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer, and wherein the polymer which incorporates a negative charge does not comprise a boronic acid receptor or a fluorophore.