Patent ID: 7384657
Filing Date: 2008-06-10
Classification: A61K

Abstract:
1. A preparation method of a composition for improving a condition of vascular disorder comprising a step of: extracting a predetermined quantity of Danshensu, a predetermined quantity of Tanshinone IIA, a predetermined quantity of matrine, a predetermined quantity of oxymatrine and a predetermined quantity of puerarin, wherein said Danshensu has a working range between 5 and 40 mg/kg per day, said Tanshinone IIA has a working range between 5 and 40 mg/kg per day, said matrine has a working range between 5 and 40 mg/kg per day, said oxymatrine has a working range between 5 and 40 mg/kg per day, and said puerarin has a working range between 5 and 40 mg/kg per day, wherein said matrine and oxymatrine are extracted by the steps of: a) immersing powder of raw matrine in methanol for obtaining a methanol extract solution which is then concentrated to form a concentrated methanol extract solution; b) diluting the concentrated methanol extract solution and adjusting a pH to about 3 such that an acid solution is formed; c) extracting with methylene chloride such that a methylene chloride extract is formed; d) extracting the methylene chloride from the extract and dissolving in chloroform such that a total alkaloids in chloroform is formed; and e) separating constituents of the total alkaloids for obtaining said matrine and said oxymatrine.