Patent ID: 7585973
Filing Date: 2009-09-08
Classification: A61P,C07D,C07F

Abstract:
1. A process for producing a folic acid-amide compound comprising: a) reacting an imidazolide represented by the following formula (A): wherein R represents a protecting group for amino acid and is an amino acid protecting group used in peptide synthesis, with γ-lower alkyl L-glutamate in an organic solvent in the presence of an organic base to form a γ-lower alkyl 2-amino-protected folate which is represented by the following formula (B): wherein R has the same definition as in formula (A), and R′ represents a lower alkyl; and b) reacting a γ-lower alkyl 2-amino-protected folate represented by the formula (B) with an amine compound of the following formula (C): wherein R″ represents amino, and L represents a valence bond, C wherein R wherein R has the same definition as in the above formula (A), and L and R″ have the same definitions as in the above formula (C).