Patent ID: 9017720
Filing Date: 2015-04-28
Classification: A61K

Abstract:
1. A method of preparing seamless capsules having a polysaccharide gel membrane on the outer surface, comprising the steps of: (a) preparing an emulsion comprising oil, water, an emulsifier, and at least one of a water-soluble monovalent metal salt, polyvalent metal salt, and an acid, wherein said oil is present in an amount of at least 50% by weight of said emulsion and said emulsion is an oil-in-water emulsion; with the proviso that said emulsion does not contain marmelo mucilage; and (b) adding portions of said emulsion to an aqueous gelling bath comprised of at least one ionic polysaccharide thereby encapsulating said portions of said emulsion in a polysaccharide gel membrane, (c) optionally drying the resulting capsules by removing water and optionally applying a coating to the outer surface of said gel membrane; wherein said polysaccharide comprises an alginate, said capsule is enteric or delayed release, and said capsule is oblong, oval or cylindrical.