Patent ID: 6777550
Filing Date: 2004-08-17
Classification: C07K

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof whereinx is 0 or 1, R1 is H, R is alkyl or arylalkyl, p is 0 or an integer from 1 to 8; and A is a conformationally restricted dipeptide mimic which has the structure where Y is CH2, R7, R8 and R9 are independently selected from hydrogen, alkyl, alkenyl, cycloalkyl-(CH2)mâ€”, aryl-(CH2)mâ€” and heteroaryl-(CH2)mâ€”, where m is O or an integer from 1 to 6; R6, R10, R11, and R12 are independently selected from hydrogen, alkyl, alkenyl, cycloalkyl-(CH2)pâ€”, aryl-(CH2)pâ€” and heteroaryl-(CH2)pâ€”; and R4 is OH wherein the term heteroaryl alone or as part of another group refers to an aromatic ring which may optionally contain at most one sulfur atom or at most one oxygen atom and/or one to four nitrogen atoms, provided that the total number of heteroatoms in the ring is 4 or less, which aromatic ring may be optionally substituted with one, two or three substituents, and which aromatic ring may be fused to a benzene ring or a pyridyl ring to form a bicyclic ring which may be optionally substituted.