Patent ID: 6339173
Filing Date: 2002-01-15
Classification: A61K,B82Y,C07C,C07K

Abstract:
A lipid having the structure: or a salt, or solvate, or enantiomer thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H; (c) R2, R3 and R4 are positively charged moieties, or at least one but not all of R2, R3 or R4 is a positive moiety and the remaining are independently selected from H, and alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and p is from 1 to 16; (e) Xâˆ’ is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms.