Patent ID: 8637077
Filing Date: 2014-01-28
Classification: A61K

Abstract:
1. A sustained-release preparation wherein the initial release of a bioactive substance is suppressed, comprising a combination of a microcapsule containing the bioactive substance and a biodegradable polymer having a weight-average molecular weight of about 3,000 to about 50,000, and a dispersion vehicle containing a basic amino acid and a polyethyleneglycol, wherein the dispersion vehicle is a water-soluble medium for suspension of the microcapsule used for injection and the basic amino acid and the polyethyleneglycol do not exist in the microcapsule and exist outside the microcapsule or on the outer surface of the microcapsule; and wherein the basic amino acid and polyethyleneglycol suppress the initial release of the bioactive substance.