Patent ID: 6858613
Filing Date: 2005-02-22
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]indolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-methylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-chloroindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-bromoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-cyanoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-ethynylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-methylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-chloroindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-bromoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-cyanoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-ethynylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-methylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloroindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-bromoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-cyanoindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-ethynylindolizine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-indolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-methylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-chloroindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-bromoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-cyanoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-ethynylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-methylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-chloroindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-bromoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-cyanoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-ethynylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-methylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloroindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-bromoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-cyanoindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-ethynylindolizine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]imidazo[1,5-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]imidazo[1,5-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]imidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-methylimidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-chloroimidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-bromoimidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-cyanoimidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-ethynylimidazo[1,2-a]pyridine-6-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]imidazo[1,2-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-methylimidazo[1,2-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-chloroimidazo[1,2-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-bromoimidazo[1,2-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-cyanoimidazo[1,2-a]pyridine-7-carboxamide; N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-ethynylimidazo[1,2-a]pyridine-7-carboxamide; any of which is optionally substituted at C-2 having the S configuration with methyl, or pharmaceutically acceptable salt thereof.