Patent ID: 6388071
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein R is hydrogen, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, an unsubstituted or hydroxy substituted cycloalkyl ring containing 5 or 6 carbon atoms, a five- or six-membered saturated heterocyclic ring which contains from 1 to 3 hetero ring atoms selected from the group consisting of sulfur, oxygen or nitrogen, or an unsubstituted five- or six-membered heteroaromatic ring, connected by a ring carbon atom, which contains from 1 to 3 heteroatoms in the ring selected from the group consisting of sulfur, nitrogen and oxygen; R3 is cycloalkyl having 3 to 7 carbon atoms; R4 is an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring, connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen adjacent to the connecting ring carbon atom; said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano,â€”(CH2)mâ€”OR6, â€”(CH2)mâ€”NHR6; n is the integer 0, 1 or 2; m is 0, 1, 2, 3 or 4; R1, R2, R6, R7 and R8 are independently hydrogen or lower alkyl and * designates the assymetric carbon atom center; or a pharmaceutically acceptable salt thereof.