Patent ID: 6949541
Filing Date: 2005-09-27
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein R denotes a saturated, mono- or di-unsaturated 5- to 7-membered aza, diaza, triaza, oxaza, thiaza, thiadiaza or S,S-dioxido-thiadiaza heterocyclic group, whilst the abovementioned heterocyclic groups are linked via a carbon or nitrogen atom and contain one or two carbonyl groups adjacent to a nitrogen atom, may be substituted by an alkyl group at one of the nitrogen atoms, may be substituted at one or two carbon atoms by an alkyl group, by a phenyl, phenylmethyl, naphthyl, biphenylyl, pyridinyl, diazinyl, furyl, thienyl, pyrrolyl, 1,3-oxazolyl, 1,3-thiazolyl, isoxazolyl, pyrazolyl, 1-methylpyrazolyl, imidazolyl or 1-methylimidazolyl groups, whilst the substituents may be identical or different, and wherein a double bond of one of the above-mentioned unsaturated heterocyclic groups may be fused with a benzene, pyridine, diazine, 1,3-oxazole, thiophene, furan, thiazole, pyrrole, N-methyl-pyrrole or quinoline ring, with a 2(1H)-oxoquinoline ring optionally substituted at the nitrogen atom by an alkyl group or with an imidazole or N-methylimidazole ring or two olefinic double bonds of one of the abovementioned unsaturated heterocyclic groups may each be fused to a benzene ring, whilst the phenyl, pyridinyl, diazinyl, furyl, thienyl, pyrrolyl, 1,3-oxazolyl, 1,3-thiazolyl, isoxazolyl, pyrazolyl, 1-methylpyrazolyl, imidazolyl or 1-methylimidazolyl groups contained in R as well as benzo-, thieno-, pyrido- and diazino-fused heterocyclic groups may additionally be mono-, di- or trisubstituted in the carbon skeleton by fluorine, chlorine or bromine atoms, by alkyl, alkoxy, nitro, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphonylamino, phenyl, trifluoromethyl, alkoxycarbonyl, carboxy, dialkylamino, hydroxy, amino, acetylamino, propionylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, (4-morpholinyl)carbonyl, (1-pyrrolidinyl)carbonyl, (1-piperidinyl)carbonyl, (hexahydro-1-azepinyl)carbonyl, (4-methyl-1-piperazinyl)carbonyl, methylenedioxy, aminocarbonylamino, alkanoyl, cyano, trifluoromethoxy, trifluoromethylthio, trifluoromethylsulphinyl or trifluoromethylsulphonyl groups, whilst the substituents may be identical or different, R whilst the abovementioned aromatic and heteroaromatic groups in the carbon skeleton may additionally be mono-, di- or trisubstituted by fluorine, chlorine or bromine atoms, by alkyl groups, cycloalkyl groups with 3 to 8 carbon atoms, phenylalkyl groups, alkenyl, alkoxy, phenyl, phenylalkoxy, trifluoromethyl, alkoxycarbonyl, carboxy, dialkylamino, nitro, hydroxy, amino, alkylamino, acetylamino, propionylamino, methylsulphonyloxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkanoyl, cyano, tetrazolyl, phenyl, pyridinyl, thiazolyl, furyl, trifluoromethoxy, trifluoromethylthio, trifluoromethylsulphinyl or trifluoromethylsulphonyl groups and the substituents may be identical or different, R one of the groups A wherein R Z denotes the carbonyl or the sulphonyl group and R in the ω position by an amino, phenyl, pyridinyl, phenoxy, phenylamino, phenylmethoxycarbonylamino or N-alkylphenylamino group, by a dialkylamino group, by a piperidinyl or piperazinyl group optionally substituted by a phenyl, pyridinyl, dimethylamino, 4-morpholinyl, 4-alkyl-hexahydro-1H-1,4-diazepin-1-yl, 4-alkyl-1-piperazinyl, 4-(alkylsulphonyl)-1-piperazinyl, 4-(dialkylaminoalkyl)-1-piperazinyl, 1-alkyl-4-piperidinyl or piperidinyl group, by a 4-methyl-1-piperazinyl group, by an N-(C independently thereof in the α position by an amino, tert.alkoxycarbonylamino or {{{[1,4′]bipiperidinyl-1′-yl}-acetyl}amino} group, whilst the abovementioned alkyl and alkenyl groups or the alkyl groups contained in the abovementioned groups, unless otherwise specified, contain 1 to 5 carbon atoms and may be branched or unbranched and the abovementioned aromatic and heteroaromatic groups may additionally be mono-, di- or trisubstituted by fluorine, chlorine or bromine atoms, by cyano or hydroxy groups and the substituents may be identical or different, or a tautomer or salt thereof.