Patent ID: 6472392
Filing Date: 2002-10-29
Classification: A61P,C07D

Abstract:
A triazole compound of formula I whereAr1 is phenyl, naphthyl or a 5- or 6-membered heterocyclic aromatic ring having from 1 to 4 heteroatoms which are independently selected from O, S and N, where Ar1 is unsubstituted or substituted by 1, 2, 3 or 4 substituents selected from C1-C6-alkyl which is unsubstituted or substituted by OH, OC1-C6-alkyl, halogen or phenyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, halogen, CN, COOR2, NR2R2, NO2, SO2R2, SO2NR2R2, OH, and phenyl which is unsubstituted or substituted by C1-C6-alkyl, OC1-C6-alkyl, NR2R2, CN, CF3, CHF2, or halogen, and where the 5- or 6-membered heterocyclic ring may be fused to a phenyl ring; A is a straight-chain or branched C4-C10-alkylene group or a straight-chain or branched group consisting of from 4 to 11 members selected from the group of from 3 to 10 methylene members and at least one member Z, wherein Z is selected from O, S, NR2, CONR2, COO, CO, a double bond and a triple bond, and the member(s) Z is(are) arranged within the chain linking the triazole ring to B between methylene members and/or between the triazole ring and a methylene member; B is a radical of the formula: Ar2 is phenyl, pyridyl, pyrimidinyl or triazinyl, where Ar2 is unsubstituted or substituted by from 1 to 4 substituents selected from OR2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy-C1-C6-alkyl, halogen-C1-C6-alkyl, halogen-C1-C6-alkoxy, halogen, CN, NO2, SO2R2, NR2R2, SO2NR2R2, a 5- or 6-membered carbocyclic, aromatic or non-aromatic ring and a 5- or 6-membered, heterocyclic aromatic or non-aromatic ring having from 1 or 2 heteroatoms which are selected from O, S and N, where the carbocyclic or heterocyclic ring is unsubstituted or substituted by C1-C6-alkyl, phenyl, phenoxy, halogen, OC1-C6-alkyl, OH, NO2 or CF3 and/or is optionally fused to a phenyl ring; and where Ar2 may be fused to a carbocyclic aromatic or non-aromatic ring or 5- or 6-membered heterocyclic aromatic or non-aromatic ring having 1 or 2 heteroatoms, selected from O, S and N, R1 is C3-C6-cycloalkyl or C1-C6-alkyl which is unsubstituted or substituted by OH or OC1-C6-alkyl; the radicals R2, which can be identical or different, are H or C1-C6-alkyl which is unsubstituted or substituted by OH, OC1-C6-alkyl or phenyl; or a salt thereof with a physiologically tolerated acid.