Patent ID: 6303780
Filing Date: 2001-10-16
Classification: C07D

Abstract:
A compound of formula II: ##STR47##or a salt or stereoisomer thereof, wherein:A is O or S;W is N or CR.sup.3 ;X is N or CR.sup.4 ;Y is N or CR.sup.5 ;Z is N or CR.sup.6 ;provided that if two of W, X, Y, and Z are N, then the remaining are other than N;R.sup.1a is selected from CF.sub.3, CF.sub.2 H, C.sub.2 F.sub.5, C.sub.1-4 alkyl, C.sub.3-5 cycloalkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl;R.sup.3 is selected from H, F, Cl, Br, I, C.sub.1-3 alkoxy, and C.sub.1-3 alkyl;R.sup.4 is selected from H. F, Cl, Br, I, C.sub.1-3 alkyl substituted with 0-3 R.sup.11, C.sub.2-3 alkenyl, C.sub.2-3 alkynyl, C.sub.1-3 alkoxy, OCF.sub.3, --CN, NO.sub.2, CHO, C(O)CH.sub.3, C(O)CF.sub.3, C(O)NH.sub.2, C(O)NHCH.sub.3, NR.sup.7 R.sup.7a, NR.sup.7 C(O)OR.sup.7a, C(O)OR.sup.7, S(O).sub.p R.sup.7, SO.sub.2 NHR.sup.7, NR.sup.7 SO.sub.2 R.sup.7b, phenyl substituted with 0-2 R.sup.10, and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R.sup.10 ;alternatively, R.sup.3 and R.sup.4 together form --OCH.sub.2 O--;R.sup.5 is selected from H, F, Cl, Br, and I;alternatively, R.sup.4 and R.sup.5 together form --OCH.sub.2 O--or a fused benzo ring;R.sup.6 is selected from H, OH, C.sub.1-3 alkoxy, --CN, F, Cl, Br, I, NO.sub.2, CF.sub.3, CHO, C.sub.1-3 alkyl, and C(O)NH.sub.2 ;R.sup.7 is selected from H and C.sub.1-3 alkyl;R.sup.7a is selected from H and C.sub.1-3 alkyl;R.sup.7b is C.sub.1-2 alkyl;R.sup.10 is selected from OH, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, F, Cl, Br, I, CN, NR.sup.7 R.sup.7a, and C(O)CH.sub.3 ;R.sup.11 is selected from OR.sup.7, CN, F, Cl, Br, I, NO.sub.2, NR.sup.7 R.sup.7a, CHO, C(O)CH.sub.3, C(O)NH.sub.2 ;p is selected from 0, 1, and 2.