Patent ID: 6054457
Filing Date: 2000-04-25
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: ##STR11## wherein R.sup.1 is aryl which is substituted with alkoxy optionally substituted with acyl, substituted acyl, acylamino or substituted acylamino;R.sup.2 is hydrogen; lower alkyl optionally substituted with hydroxy, aryl or acyl; or cyclo(lower)alkyl;R.sup.3 is hydrogen; halogen; hydroxy; acyloxy; substituted acyloxy; lower alkyl optionally substituted with hydroxy or lower alkoxy; lower alkoxy optionally substituted with aryl, amino, protected amino, acyl, hydroxy, cyano or lower alkylthio; nitro; amino; acyl; substituted acyl; or cyclo(lower)alkyloxy;R.sup.4 is lower alkoxy optionally substituted with hydroxy, aryl, substituted aryl, acyl, substituted acyl, amino, lower alkylamino, acylamino, substituted acylamino, protected amino, a heterocyclic group or guanidino;R.sup.5 is hydrogen, lower alkyl, lower alkoxy or halogen;A is NH;E is ##STR12## X is --CH.dbd.CH--; and Y is CH;and pharmaceutically acceptable salts thereof.