Patent ID: 6683210
Filing Date: 2004-01-27
Classification: A61K,A61P,C07K

Abstract:
Compound represented by the formula:or a pharmaceutically acceptable salt, prodrug or ester thereof, whereinR1 represents alkyl of 1-5 carbon atoms, alkenyl of 2-5 carbon atoms, alkynyl of 2-5 carbon atoms, hydroxyalkyl of 1-3 carbon atoms, alkoxyalkyl of 1-3 alkyl and 1-3 alkoxy carbon atoms, cyanoalkyl of 1-3 alkyl carbon atoms, imidazolylmethyl, â€”CH2CONH2, â€”CH2CH2CONH2, â€”CH2S(O)2NH2, â€”CH2SCH3, â€”CH2S(O)CH3, â€”CH2S(O)2CH3, â€”C(CH3)2SCH3, â€”C(CH3)2S(O)CH3 or â€”C(CH3)2S(O)2CH3 radicals; R2 represents radicals of alkyl of 1-5 carbon atoms, aralkyl of 1-3 alkyl carbon atoms, alkylthioalkyl of 1-3 alkyl carbon atoms, arylthioalkyl of 1-3 alkyl carbon atoms or cycloalkylalkyl of 1-3 alkyl carbon atoms and 3-6 ring member carbon atoms; R3 represents radicals of alkyl radical of 1-5 carbon atoms, cycloalkyl of 5-8 ring members or cycloalkylmethyl radical of 3-6 ring members; R10 represents hydrogen, alkyl, hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl and alkoxy are each 1-3 carbon atoms; R11 represents alkyl of 1-5 carbon atoms, hydroxyalkyl of 1-4 carbon atoms, alkoxyalkyl of 1-4 alkyl carbon atoms, benzyl, imidazolylmethyl, â€”CH2CH2CONH2, â€”CH2CONH2, â€”CH2CH2SCH3 or â€”CH2SCH3 radicals or the sulfone or sulfoxide derivatives thereof; R4 represents aryl; and, R12 and R13 each independently represent hydrogen, alkyl, aralkyl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, aryl or heteroaryl radicals, wherein alkyl is 1-5 carbon atoms, cycloalkyl is 3-6 ring membered cycloalkyl optionally benzo fused, and heteroaryl is 5 to 6 ring membered heteroaryl optionally benzo fused.