Patent ID: 7544638
Filing Date: 2009-06-09
Classification: B01J,B82Y,C07B,C07H,C07K,C40B,G03F

Abstract:
1. A method for parallel synthesis of an array of selected multimers on a substrate comprising fluidly isolated reaction sites containing one or more protected initiation moieties, the method comprising: (a) selectively irradiating, using a spatial optical modulator comprising a digital micromirror device, fluidly isolated reaction sites to generate deprotected initiation moieties at the irradiated fluidly isolated reaction sites; wherein the deprotected initiation moieties are generated by: (b) coupling one or more monomers to the deprotected initiation moieties to generate new protected initiation moieties; and (c) repeating steps (a)-(b) until the array of selected multimers has been synthesized; wherein the coupling reactions to synthesize the array of selected multimers occur with a yield of 98% or greater.