Patent ID: 6099862
Filing Date: 2000-08-08
Classification: A61K,A61P

Abstract:
A controlled release pharmaceutical tablet which consisting essentially of:(a) a core consisting essentially of:(i) metformin or a pharmaceutically acceptable salt thereof;(ii) glipizide(iii) polyvinyl pyrrolidone; and(iv) sodium lauryl sulfate;(b) optionally a seal coat around the core,(c) a semipermeable membrane coating covering said core comprising:(i) cellulose acetate;(ii) polyethylene glycol with an average molecular weight between 380 and 420; and(iii) a plasticizer; and(d) at least one passageway in the semipermeable membrane to allow the release of the metformin and glipizide from the core to the environment of use to provide therapeutic levels of metformin and glipizide from twelve to twenty-four hour periods.