Patent ID: 9062108
Filing Date: 2015-06-23
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating a subject for an inflammatory disorder, comprising administering a binding protein to the subject, wherein the binding protein comprises first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-X2, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker; X2 is an Fc region that is either present or absent; and n is 0 or 1; wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding IL-1β and IL-17, wherein (i) the variable domains that form a functional target binding site for IL-1β comprise: and (ii) the variable domains that form a functional target binding site for IL-17 comprise