Patent ID: 7815940
Filing Date: 2010-10-19
Classification: A61K,A61P

Abstract:
1. A method for the treatment of at least one symptom of gastro-esophageal reflux disease (GERD) in a human suffering from GERD consisting essentially of administering an oral pharmaceutical dosage form into a gastro-intestinal tract of a human suffering from GERD, the oral pharmaceutical dosage form consisting essentially of a proton pump inhibitor or a salt thereof (PPI), an H2 receptor antagonist or a salt thereof (H2RA), a pharmaceutically acceptable carrier, an enteric coating on the PPI that separates the PPI from the H2RA, and optionally an antacid agent and/or alginate, wherein the PPI is selected from lansoprazole, omeprazole, pantoprazole, rabeprazole, pariprazole, leminoprazole, their pharmaceutically acceptable salts, enantiomers and salts of enantiomers, wherein the H2RA is selected from cimetidine, ranitidine, nizatidine and famotidine, their pharmaceutically acceptable salts, isomers and salts of isomers, and wherein administering the oral pharmaceutical dosage form orally introduces into the gastro-intestinal tract of the human suffering from GERD the PPI in combination with the H2RA separated from the PPI by the enteric coating.