Patent ID: 7754777
Filing Date: 2010-07-13
Classification: B01F,B01J

Abstract:
1. A method for obtaining micro- and nanodisperse systems comprising the steps of: a) Dissolving or suspending a compound C in a fluid A, in order to obtain a mixture A in the form of a solution or dispersion; b) Thermostatising said mixture A at a temperature T of between −50° C. and 200° C.; c) Adding a fluid B to said mixture A until a pressure P to form a solution AB, wherein the pressure P is equal or lower than 100 bars; d) Reducing the pressure P of the solution AB to a pressure lower than 100 bars, giving rise to a fall in temperature caused by the evaporation of fluid B that is ideally homogeneous throughout the solution AB and that gives rise to an increase of supersaturation, such that the compound C separates out in a solid form or a liquid form of micro-, submicro- or nanoscopic size suspended in the depressurized mixture; e) Adding a fluid E, in which fluid A is miscible and compound C is partially or totally insoluble at atmospheric pressure, so that the addition of said fluid E interrupts the crystallization of compound C and thus the crystalline growth of the particles; and f) Removing the fluid A remaining in the dispersion of step (e) by separation; wherein the micro- and nanodisperse systems obtained are selected from liposomes, emulsions or suspensions; wherein compound C is partially or totally insoluble in fluid E, and capable of being dispersed in fluid E and fluid A; and wherein fluid E is a polar or an apolar solvent or mixture of both.