Patent ID: 6576478
Filing Date: 2003-06-10
Classification: B82Y,Y10S,Y10T

Abstract:
A multi-channel sample detection device, comprising(a) a substrate having an upper surface, (b) a plurality of discrete open channels formed in or on said substrate adjacent said upper surface, each channel extending between first and second ends and having a bottom wall surface defining an immobilization region intermediate said first and second ends, (c) a cover attached to said substrate's upper surface and forming with each channel a closed channel having open first and second ends, said cover being part of a detection system for detecting interactions within each channel, where said first ends of said channels arranged so that said channels can each be both independently loaded with an analyte containing fluid, or simultaneously loaded with said fluid by loading said channels simultaneously with a bulk-loading dispenser device, (d) a plurality of immobilization molecules for immobilizing selected proteins or peptides or small molecules or nucleic acids, said immobilization molecules being chemisorbed or physisorbed to said immobilization region in each channel, wherein when said liquid containing said one or more analytes is introduced into said channels to interact with said peptides or proteins or small molecules or nucleic acids, such interactions, if any, can be detected by said detection device.