Patent ID: 6461388
Filing Date: 2002-10-08
Classification: A61K,A61Q,C07D,Y02P

Abstract:
A p-diaminobenzene derivative compound of formula I, or a phyiologically compatible water-soluble salt thereof: wherein X6, X7, X8, X9, X10, each, independently of each other, represents nitrogen or Câ€”R6, Câ€”R7, Câ€”R8, Câ€”R9, Câ€”R10, with the proviso that at least one and at most three of the groups, X6, X7, X8, X9, X10, represent nitrogen and R6, R7, R8, R9, R10 each, independently of each other, represents hydrogen, a halogen atom, a cyano group, a hydroxy group, a C1- to C4-alkoxy group, a C1- to C6-alkyl group, a C1- to C4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C1- to C4-alkylamino group, a di(C1- to C4-)alkylamino group, a trifluoromethane group, a â€”C(O)H group, a â€”C(O)CH3 group, a â€”C(O)CF3 group, a â€”Si(CH3)3 group, a â€”C(O)NH2 group, a C1- to C4-hydroxyalkyl group, a C3- to C4-dihydroxyalkyl group, a â€”CH&boxH;CHR11 group, a â€”(CH2)pâ€”CO2R12 group or a â€”(CH2)pR13 group with p=1, 2, 3 or 4, a â€”C(R14)&boxH;NR15 group or a â€”C(R17)Hâ€”NR18R19 group; R1, R2, R3 and R4 each, independently of each other, represents hydrogen, a C1- to C6-alkyl group, a C1- to C4-hydroxyalkyl group, a C2- to C4-dihydroxyalkyl group or a C1- to C4-alkoxy-(C1- to C4)-alkyl group or R1 and R2 or R3 and R4 represent a four-membered to eight-membered aliphatic ring, with the proviso that at least two of the R1 to R4 groups represent hydrogen; R5 represents hydrogen, a hydroxy group, a halogen atom, a C1- to C4-alkyl group, a C1- to C4-hydroxyalkyl group or a C1- to C4-alkoxy group; R11 represents hydrogen, a hydroxy group, an amino group, a â€”CO2R12 or a â€”C(O)CH3 group; R12, R14 and R17 each, independently of each other, represents hydrogen or a C1- to C4-alkyl group; R13 represents an amino group or a nitrile group; R15, R18 and R19 each, independently of each other, represents hydrogen, a hydroxy group, a C1- to C4-alkyl group, a C1- to C4-hydroxyalkyl group, a C3- to C4-dihydroxyalkyl group or a group of the formula: â€ƒand wherein R16 represents hydrogen, an amino group or a hydroxy group.