Patent ID: 8101641
Filing Date: 2012-01-24
Classification: A61K,A61P,C07D

Abstract:
1. A compound, wherein the compound is selected from the group consisting of: 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2-hydroxybenzoic acid; 5-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2-hydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-5-hydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,6-dihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,5-dihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,4-dihydroxybenzoic acid; 5-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,3-dihydroxybenzoic acid; 5-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,4-dihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-4,5-dihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,5,6-trihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,4,6-trihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,4,5-trihydroxybenzoic acid; 5-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,3,4-trihydroxybenzoic acid; 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-2,4,5,6-tetrahydroxybenzoic acid; 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-(5-m-tolyl-[1,2,4]oxadiazol-3-yl)-benzoic acid; 3-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-(5-phenyl-[1,2,4]oxadiazol-3-yl)-benzoic acid; 3-[5-(4-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(2-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(2-hydroxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-[5-(3-Bromo-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(4-tert-Butyl-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-(5-Ethyl-[1,2,4]oxadiazol-3-yl)-4-hydroxy-benzoic acid; 3-[5-(2,4-Difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(2,4-Dichloro-5-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(4-Cyano-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(4-Dimethylamino-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(5-Bromo-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(2,3-Difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(5-Chloro-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(4-hydroxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 4-Hydroxy-3-(5-phenoxymethyl-[1,2,4]oxadiazol-3-yl)-benzoic acid; 4-Hydroxy-3-[5-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-[5-(2,5-Difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(3,5-Difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(3,5-Bis-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(2-Fluoro-4-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-[5-(2-Fluoro-5-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(2,4,6-trichloro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-[5-(3-Cyano-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-(5-Biphenyl-4-yl-[1,2,4]oxadiazol-3-yl)-4-hydroxy-benzoic acid; 3-[5-(2-Fluoro-3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 4-Hydroxy-3-(5-naphthalen-1-yl-[1,2,4]oxadiazol-3-yl)-benzoic acid; 4-Hydroxy-3-[5-(3-nitro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-(5-Butyl-[1,2,4]oxadiazol-3-yl)-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-(5-But-2-enyl-[1,2,4]oxadiazol-3-yl)-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(4-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 4-Hydroxy-3-[5-(3-sulfo-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; 3-[5-(4-Bromo-phenyl)-[1,2,4]oxadiazol-3-yl]-4-hydroxy-benzoic acid; 3-(5-Benzyl-[1,2,4]oxadiazol-3-yl)-4-hydroxy-benzoic acid; 4-Hydroxy-3-[5-(4-nitro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, and 4-Hydroxy-3-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-benzoic acid.