Patent ID: 6706265
Filing Date: 2004-03-16
Classification: A61K,A61P,C07K

Abstract:
An aglycosylated IgG antibody which specifically binds CD3, having a heavy chain with three CDRs comprising the amino acid sequences (a) Ser-Phe-Pro-Met-Ala (SEQ ID NO:1), (b) Thr-Ile-Ser-Thr-Ser-Gly-Gly-Arg-Thr-Tyr-Tyr-Arg-Asp-Ser-Val-Lys-Gly (SEQ ID NO:2), (c) Phe-Arg-Gln-Tyr-Ser-Gly-Gly-Phe-Asp-Tyr (SEQ ID NO:3), or an antigen binding fragment thereof, and a light chain with three CDRs comprising the amino acid sequences:(d) Thr-Leu-Ser-Ser-Gly-Asn-Ile-Glu-Asn-Asn-Tyr-Val-His (SEQ ID NO:4), (e) Asp-Asp-Asp-Lys-Arg-Pro-Asp (SEQ ID NO:5), (f) His-Ser-Tyr-Val-Ser-Ser-Phe-Asn-Val (SEQ ID NO:6), or an antigen binding fragment thereof, the heavy chain CDRs being arranged in the order (a), (b), (c) in the leader to constant domain direction and the light chain CDRs being arranged in the order (d), (e), (f) in the leader to constant domain direction.