Patent ID: 6762320
Filing Date: 2004-07-13
Classification: A61P,C07C

Abstract:
A compound of the formula whereinR1 is halogen, halogen-(C1-C6)-alkyl, cyano, (C1-C6)-alkoxy or halogen-(C1-C6)-alkoxy; R21, R22, R23 and R24 are each independently selected from the group consisting of hydrogen, (C1-C6)-alkyl, halogen, halogen-(C1-C6)-alkyl, hydroxy, (C1-C6)-alkoxy or â€”CHO; R3 is hydrogen or (C1-C3)-alkyl; R4, R5 are each independently selected from the group consisting of hydrogen, (C1-C6)-alkyl, (C1-C6)-alkoxy or â€”COO(C1-C6)alkyl, or, alternatively, R4 and R5, together with the C-atom to which they are attached, for a (C3-C7)-cycloalkyl ring; R6 is â€”COâ€”NR7R8, â€”COO(C1-C6)-alkyl, â€”CN, â€”N(R)2 or â€”NHC(O)R; R7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C6)-alkyl, NH2 or hydroxy; R is hydrogen or (C1-C6)-alkyl; n is 0, 1, 2 or 3; X is â€”CHRO, â€”OCHRâ€”, â€”CH2Sâ€”, â€”SCH2â€”, â€”CH2CH2â€”, â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”; or a pharmaceutically acceptable salt thereof.