Patent ID: 8158791
Filing Date: 2012-04-17
Classification: A61P,C07D

Abstract:
1. A compound which is selected from the group consisting of: trans-5′-chloro-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-chloro-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-6′-azaisobenzofuran]-4-carboxamide, trans-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-7′-azaisobenzofuran]-4-carboxamide, trans-5′-fluoro-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-6′-azaisobenzofuran]-4-carboxamide, trans-5′-ethoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-methoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-ethoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-methoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-propoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(morpholin-4-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(dimethylamino)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(piperidin-1-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(piperidin-1-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-phenoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(pyridin-3-yloxy)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-phenyl-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-phenyl-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran] -4-carboxamide, trans-5′-(4-fluorophenyl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(pyrimidin-5-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(6-methoxypyridin-3-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-[4-(methylsulfonyl)phenyl]-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(6-methoxypyridin-3-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(1-methyl-1H-pyrazol-4-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(2,4-dimethoxypyrimidin-5-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-ethyl-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, N-methyl-7′-oxo-N-(2-piperidin-1-ylethyl)-7′H-spiro[cyclohexane-1,5′-furo[3 ,4-b]pyridine]-4-carboxamide, trans-4′-chloro-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-chloro-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-methoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-methoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-ethoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-ethoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-isopropoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-isopropoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-cyclopropylmethoxy-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-methyl-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-ethyl-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-phenyl-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(4-fluorophenyl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(1-methyl-1H-pyrazol-4-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-phenoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(4-fluorophenoxy)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(pyrrolidin-1-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(piperidin-1-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(pyrrolidin-1-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-4′-(morpholin-4-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-5′-azaisobenzofuran]-4-carboxamide, trans-5′-(pyridin-3-yl)-3′-oxo-N-methyl-N-(2-pyrrolidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-(pyridin-3-yl)-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-pyrazinyl-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-benzyloxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, trans-5′-hydroxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, and trans-6′-bromo-5′-methoxy-3′-oxo-N-methyl-N-(2-piperidin-1-ylethyl)-spiro[cyclohexane-1,1′-(3′H)-4′-azaisobenzofuran]-4-carboxamide, or a pharmaceutically acceptable salt thereof.