Patent ID: 8003614
Filing Date: 2011-08-23
Classification: A61K,A61P,A61Q,C07K

Abstract:
1. A method of preparing γ-L-glutamyl-Selenomethyl-L-selenocysteine comprising steps of: a) reacting glutamic acid with P-(1-chloro-1, 3-dihydro-3-oxo-1-isobenzofuranyl)-phosphonic acid diethyl ester in aqueous sodium carbonate or potassium carbonate solution to form N-phthaloyl-L-glutamic acid; b) reacting N-phthaloyl-L-glutamic acid with acetic anhydride to produce N-phthaloyl-L-glutamic anhydride; c) reacting N-phthaloyl-L-glutamic anhydride selenomethyl-L-selenocycteine to produce γ (N-phthaloyl-L-glutamyl)-selenomethyl-L-selenocysteine, and d) deprotecting the product of step (c) by hydrazinolysis of the phthalimide group to yield γ-L-glutamyl-Selenomethyl-L-selenocysteine.