Patent ID: 6075016
Filing Date: 2000-06-13
Classification: C07D

Abstract:
A compound of Formula I: ##STR14## wherein: rings ""A"" and ""B"" are unsaturated or partially unsaturated;X.sub.1 is selected from CH, C--Cl, or N;X.sub.2 is selected from CR.sub.12 or N;X.sub.3 is selected from CH or N;X.sub.4 is selected from CH or N, wherein at least one of X.sub.1 to X.sub.4 is N;P.sub.1, P.sub.2 are independently selected from CH, O, N or NH, provided that at least one of P.sub.1 and P.sub.2 is not CH;M is selected from CH, C, or N;Q is C.sub.1 -C.sub.3 alkylene or --CH.dbd.CH--;R.sub.6 is selected from --C(R.sub.9).sub.3, --CH(R.sub.9).sub.2, or --C.sub.3 -C.sub.8 -cycloalkyl;R.sub.7 is selected from --SH, OH or OCOR.sub.9, wherein R.sub.9 is defined below;R.sub.8 is selected from --C(R.sub.9).sub.3, --CH(R.sub.9).sub.2, --C.sub.3 -C.sub.8 -cycloalkyl, or --CH.sub.2 --C.sub.4 -C.sub.6 -cycloalkyl;R.sub.10 is selected from C.sub.1 -C.sub.3 -pyridyl, C.sub.3 H.sub.6 OH, --C.tbd.CH, Br, --C.tbd.C--CH.sub.2 OH, isopropyl, hydrogen, ##STR15## R.sub.11 is selected from H, --OH, --O--C.sub.3 -C.sub.8 -cycloalkyl, --SH, --Z-pyridyl, --Z-thienyl, and --Z--CH.sub.2 OH;R.sub.12 is selected from --SH, H, halogen or lower alkyl;R.sub.9 is lower alkyl; andZ is selected from ethylene, and --C.tbd.C--, and pharmaceutically acceptable salts thereof.