Patent ID: 8421019
Filing Date: 2013-04-16
Classification: G01N

Abstract:
1. A method for obtaining a mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) for detecting or diagnosing immunoglobulin disorders or for quantifying immunoglobulin levels in a subject, comprising: acquiring FTIR spectra for at least one dried biological fluid sample; preprocessing the FTIR spectra by differentiation and smoothing to enhance weak spectral features and to remove baseline variations; and normalizing the preprocessed FTIR spectra to a common intensity range, the normalization being performed in a spectral sub-region defined by strongest infrared (IR) absorption for a protein to obtain the spectroscopic profile for providing a basis to detect or diagnose immunoglobulin disorders or to quantify immunoglobulin levels.