Patent ID: 6627757
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A process for preparing a compound of Formula I is prepared by a process which comprises:a) mixing a compound of Formula II in tetrahydrofuran in the presence of an acid, or alternatively in tetrahydrofuran in the absence of an acid, to form a mixture;b) combining the mixture of step a) with a catalyst selected from either (A) a compound selected from the group of compounds represented by Formula III, or (B) a compound of Formula IV, wherein R1 of Formula III is a (C1-C6)alkyl and wherein R and S indicate stereochemistry at the chiral carbons;c) reducing the ketone adjacent to the p-fluorophenyl with a borane-tetrahydrofuran complex; and d) quenching the reaction with MeOH.