Patent ID: 8575164
Filing Date: 2013-11-05
Classification: A61K,A61P

Abstract:
1. A method for treating cancer, wherein the cancer is non-small cell lung cancer, colorectal cancer, pancreatic cancer or breast cancer, comprising administering to a patient simultaneously or sequentially: (i) a therapeutically or sub-therapeutically effective amount of an anti-cancer agent that inhibits serine phosphorylation of IRS1, or a pharmaceutically salt thereof; and (ii) a therapeutically or sub-therapeutically effective amount an IGF-1R inhibitor represented by the formula: wherein: A is CH or N; X is CH or N; Y and Z are independently H, methyl, ethyl, or halogen; and R G or G R or in the case of —NR each G or in the case of —NR R or R j4, j4a, and j5a are each independently 0, 1, or 2.