Patent ID: 6254852
Filing Date: 2001-07-03
Classification: A61K

Abstract:
A targeted ultrasound contrast agent, comprising: a pharmaceutically acceptable carrier and a particle of the formula:P--L--Twherein;P is a porous particle of an inorganic material having an average particle diameter of about 0.05 to 500 microns and containing an entrapped gas or liquid;L is absent or is a silane of the formula:R.sup.1 --O--Si(R.sup.2)(R.sup.3)(CH.sub.2).sub.m (O).sub.n (R.sup.4)whereinm is 0, 1, 2, or 3;n is 0 or 1;R.sup.1 is selected from --CH.sub.2 --, CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)CH.sub.2 --, and --CH.sub.2 CH.sub.2 CH.sub.2 --;R.sup.2 is selected from --CH.sub.3, --CH.sub.2 CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 CH.sub.2 CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl;R.sup.3 is selected from --CH.sub.3, --CH.sub.2 CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 CH.sub.2 CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl;R.sup.4 is selected from the group C.sub.1-6 alkyl substituted with 1-2 R.sup.5, C.sub.2-6 alkenyl substituted with 1-2 R.sup.5, phenyl substituted with 1 R.sup.5, C.sub.3-6 cycloalkyl substituted with 1-2 R.sup.5, and glycidyl; andR.sup.5, at each occurrence, is --O-- or --NH--; andT is a targeting ligand.