Patent ID: 8747669
Filing Date: 2014-06-10
Classification: B01D,B01L,G01N

Abstract:
1. A module for filtration of a liquid sample comprising: a housing having a feed port and a retentate port; a filter comprising a single pass tangential flow filtration (TFF) separation element comprising a membrane, the filter disposed within the housing comprising at least one flow channel having a flow channel inlet disposed at a first end of the flow channel and coupled to the feed port, a flow channel outlet coupled to the retentate port and disposed at a second opposite end of the separation element; the housing includes a permeate port which is fluidly coupled to the separation element; the housing is adapted to place the separation element in communication with a vacuum source; wherein the at least one flow channel has a length a characterized by a dimensionless length greater than about 4000; a feed reservoir disposed within the housing and fluidly coupled to the feed port; a permeate reservoir fluidly coupled to the permeate port; and a vacuum source in communication with the permeate reservoir to apply a first vacuum to the separation element.