Patent ID: 6455576
Filing Date: 2002-09-24
Classification: A61P,C07H

Abstract:
A compound of formula whereinR is hydrogen or methyl; R1 and R2 are both hydrogen or they together form a bond; R3 is hydrogen, a linear or branched C1-C5 alkyl group, a benzyl group, optionally substituted by one or more substituents selected among nitro groups, hydroxy groups, carboxylic groups, amino groups, linear or branched C1-C5 alkyl groups, C1-C4 alkoxycarbonyl groups, aminocarbonyl groups or ciano groups, or a chain of formula â€ƒwherein A is hydrogen or a phenyl group optionally substituted by one or two substituents selected among nitro groups, hydroxy groups, carboxylic groups, amino groups, linear or branched C1-C5 alkyl groups, C1-C4 alkoxycarbonyl groups, aminocarbonyl groups or ciano groups, or a 5 or 6 membered heterocycle, sated or unsaturated, containing from 1 to 3 heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted by one or two substituents selected among C1-C5 alkyl groups, phenyl groups, hydroxy groups, oxo (&boxH;O) groups, nitro groups, C1-C4 alkoxycarbonyl groups, aminocarbonyl groups, mono or di-C1-C4-alkylaminocarbonyl groups, C1-C4-alkylcarbonyl groups; X and Y, the same or different, are O, S, SO, SO2 or NR4, in which R4 is hydrogen, a linear or branched C1-C5 alkyl group, a C1-C5 alkoxycarbonyl group, a benzyloxycarbonyl group; r is an integer from 1 to 6; m is an integer from 1 to 8; n is an integer from 0 to 2; and their pharmaceutically acceptable salts;the compounds 3â€²-desdimethylamino-3â€²,4â€²-dehydroerythromycin A oxime and 3â€²-desdimethylamino-3â€²,4â€²-dehydroerythromycin A 9-O-methyloxime being excluded.