Patent ID: 6469040
Filing Date: 2002-10-22
Classification: A61K

Abstract:
A method of treating a neoplasia in a subject in need of such treatment, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula II or a pharmaceutically acceptable salt thereof whereinR1 is methyl or amino; R4 is (i) C1-C6 haloalkyl, (ii) phenyl optionally substituted with one or more members independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, halogen, hydroxy, amino, C1-C6 alkyl amino, and di-C1-C6 alkylamino groups, or (iii) thienyl optionally substituted with one or more members independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, halogen, hydroxy, amino, C1-C6 alkylamino, and di(C1-C6)alkylamino groups; and R6 is phenyl optionally substituted at a substitutable position with one or more radicals selected from the group consisting of halo, C1-C6 alkylthio, C1-C6 alkylsulfonyl, cyano, nitro, C1-C6 haloalkyl, C1-C6 alkyl, hydroxyl, C1-C6 alkenyl, C1-C6 hydroxyalkyl, carboxyl, C1-C6 cycloalkyl, C1-C6 alkylamino, C1-C6 dialkylamino, C1-C6 alkoxycarbonyl, aminocarbonyl, C1-C6 alkoxy, C1-C6 haloalkoxy, sulfamyl, five or six membered heterocyclic radicals, and amino.