Patent ID: 7727748
Filing Date: 2010-06-01
Classification: A23K,C12P

Abstract:
1. A process for preparing D-pantothenic acid and/or salts thereof, which comprises a) fermenting at least one bacterium from the Bacillaceae family which produces D-pantothenic acid and in which the biosynthesis of pantothenic acid (pan) and/or isoleucine/valine (ilv) is deregulated and which forms at least 2 g/L of salts of D-pantothenic acid by fermentation in a culture medium, b) passing the D-pantothenate-containing fermentation solution through an anion exchanger and thereby binding the D-pantothenic acid to the anion exchanger, remaining compounds, including monovalent cations, passing through the anion exchanger, c) removing the D-pantothenic acid from the anion exchanger by eluting the D-pantothenate bound to the anion exchanger in the form of calcium and/or magnesium D-pantothenate by a solution containing inorganic or organic calcium salts and/or magnesium salts and/or inorganic calcium bases and/or magnesium bases and/or organic calcium bases and/or magnesium bases, or eluting the bound D-pantothenate in the form of free D-pantothenic acid using an HCI solution, d) optionally adding calcium base and/or magnesium base to set the free D-pantothenic acid-containing eluate to a pH of 3-10, a solution being obtained which contains calcium and/or magnesium pantothenate and e) subjecting the eluate or the solution containing calcium pantothenate and/or magnesium pantothenate to drying and/or formulation wherein no free β-alanine and/or β-alanine salt is fed to the culture medium.