Patent ID: 6479641
Filing Date: 2002-11-12
Classification: A61K,G01N

Abstract:
An isolated binding moiety for human parvovirus B19 or a fragment thereof that is immunological cross-reactive with human parvovirus B19, which binding moiety is a polypeptide comprising an amino acid sequence of the formula:I. Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa (SEQ ID NO:24); orII. Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa (SEQ ID NO:25); orIII. Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa (SEQ ID NO:26); whereXaa can be any amino acid, with the proviso that said polypeptide is capable of binding to said virus or fragment thereof in a solution at physiological pH and dissociating from said virus in a solution at pH 2.