Patent ID: 6468795
Filing Date: 2002-10-22
Classification: A61K,C12N,Y02P

Abstract:
A compound 19 to 50 nucleobases in length targeted to nucleobases 2477 through 2548 of a nucleic acid molecule encoding human Apaf-1 of SEQ ID NO: 17, nucleobases 303 through 546 of a 5â€²-untranslated region, or nucleobases 596 through 4065 of a coding region, of a nucleic acid molecule encoding human Apaf-1 of SEQ ID NO: 21, or nucleobases 604 through 4205 of a coding region of a nucleic acid molecule encoding mouse Apaf-1 of SEQ ID NO: 10, wherein said compound specifically hybridizes with one of said regions and inhibits the expression of human or mouse Apaf-1.