Patent ID: 7807677
Filing Date: 2010-10-05
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula I: wherein R R R X is H, F, OH, C L is OH, F, NH n is 0, 1 or 2; E is N, CH; A′ is a bicyclic ring system comprising a first 5 or 6 membered saturated ring optionally containing an oxygen hetero atom and optionally substituted with hydroxy and/or methyl, having fused thereto a second 5 or 6 membered unsaturated ring optionally containing one or two hetero atoms selected from S, O and N, and optionally substituted with mono- or di-fluoro; or A′ is a group of formula (II), (II′), (III) or (IV): wherein; R R R Z is bond, —NH—, —O—; Rx is H, C t is 0 or 1; A″ is a group of formula (V), (VI) (VII) or (VIII); wherein; R 8 is H; or R 8 is C 1 -C 6 Alk, C 0 -C 3 alkanediylcarbocyclyl, C 0 -C 3 alkanediylheterocyclyl, any which is optionally substituted with up to three substituents independently selected from R 11 ; R W is a bond, —NR R D is O or NH; Ry is H or Ry, together with the adjacent C atom defines a fused furan or pyran ring; Q is O, CHR R q and r are independently 0 or 1; R Y is a bond or C Ra is H or C Rb is H or C p is 1 or 2; R Ra′ is H or C C C C C or pharmaceutically acceptable salts thereof.