Patent ID: 8802625
Filing Date: 2014-08-12
Classification: A61K,A61P

Abstract:
1. A method of treating reduced renal function in an infant or fetus in need thereof, comprising: administering to the infant or fetus a therapeutically effective amount of a pharmaceutical composition comprising colony stimulating factor-1 protein (CSF-1), or a precursor, variant, isoform, analogue, or derivative thereof; wherein: i) the precursor, variant, isoform, analogue, or derivative of CSF-1 has retained substantial similarity in biological function to CSF-1 and comprises the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein; and ii) the treated infant or fetus has an improvement in renal function, comprising a promotion in kidney development, an increase in kidney weight or volume, an increase in kidney growth, an increase in nephrogenesis, an increase in the number of nephrons, enhanced nephrogenesis, or kidney maturation.