Patent ID: 8802888
Filing Date: 2014-08-12
Classification: C07C

Abstract:
1. Process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl comprising a) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-50° C. in the presence of Pd/C under 0.1-0.6 bar overpressure, and b) further hydrogenating the 4-aminophenyl acetic acid obtained in situ in step a) at a temperature between 50-60° C. under 1-4 bar overpressures, then c) heating the 4-aminocyclohexil acetic acid obtained in step b) to reflux for 1-3 hours in hydrochloric ethanol, and optionally after removing the solvent, acetonitrile is added to the residue obtained and then distilled off.