Patent ID: 6191284
Filing Date: 2001-02-20
Classification: C07B,C07F

Abstract:
An enantiomer-enriched ligand of formula (I) and salts thereof: ##STR36##wherein R.sup.1 and R.sup.2, independent of one another, are R.sup.8, NR.sup.6 R.sup.7, SR.sup.6, (C.sub.1 -C.sub.18)-alkyl, (C.sub.1 -C.sub.18)-alkoxy, (C.sub.2 -C.sub.18)-alkoxylalkyl, (C.sub.1 -C.sub.18)-acyloxy, (C.sub.6 -C.sub.18)-aryl, (C.sub.7 -C.sub.19)-aralkyl, (C.sub.3 -C.sub.18)-heteroaryl, (C.sub.4 -C.sub.19)-heteroaralkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.6 -C.sub.18)-aryl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.19)-heteroalkyl, (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.8)-alkyl;or R.sup.1 and R.sup.2 are bonded via a (C.sub.3 -C.sub.7) carbocycle, which can be substituted one or more times by linear or branched (C.sub.1 -C,)-alkyl, (C.sub.1 -C.sub.8)-acyl, (C.sub.1 -C.sub.8)-alkoxy, (C.sub.2 -C.sub.8)-alkoxyalkyl and/or can contain heteroatoms like N, O, P, S in the ring;R.sup.3 and R.sup.4, independent of one another, are H, (C.sub.1 -C.sub.18)-alkyl, (C.sub.1 -C.sub.18)-alkoxy, (C.sub.2 -C.sub.18)-alkoxylalkyl, (C.sub.1 -C.sub.18)-acyloxy, (C.sub.6 -C.sub.18)-aryl, (C.sub.7 -C.sub.19)-aralkyl, (C.sub.3 -C.sub.18)-heteroaryl, (C.sub.4 -C.sub.19)-heteroaralkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.6 -C.sub.18)-aryl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.19)-heteroalkyl, (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.8)-alkyl;or R.sup.3 and R.sup.4 are bonded via a (C.sub.3 -C.sub.5) bridge, optionally containing at least one double bond and/or optionally substituted by at least once by linear or branched (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-acyl, (C.sub.1 -C.sub.8)-alkoxy, (C.sub.2 -C.sub.8)-alkoxyalkyl and/or optionally contains at least one heteroatom selected from the group consisting of N, O, P and S in the ring;R.sup.5 is (C.sub.1 -C.sub.18)-alkyl, (C.sub.6 -C.sub.18)-aryl, (C.sub.3 -C.sub.18)-heteroaryl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.6 -C.sub.18)-aryl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.19)-heteroalkyl, (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.8)-cycloalkyl, where the residues R.sup.5 on the same phosphorus atom and/or the two phosphorus atoms can be different;R.sup.6 and R.sup.7, independent of one another, are H, (C.sub.1 -C.sub.18)-alkyl, (C.sub.1 -C.sub.8)-alkoxy, (C.sub.2 -C.sub.8)-alkoxylalkyl, (C.sub.1 -C.sub.8)-acyl, (C.sub.6 -C.sub.18)-aryl, (C.sub.7 -C.sub.19)-aralkyl, (C.sub.3 -C.sub.18)-heteroaryl, (C.sub.4 -C.sub.19)-heteroaralkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.6 -C.sub.18)-alkyl, (C.sub.1 -C.sub.8)-alkyl-(C.sub.3 -C.sub.19)-heteroalkyl, (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.8)-alkyl (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 -C.sub.8)-alkyl;or R.sup.6 and R.sup.7 are bonded via a (C.sub.3 -C.sub.7) carbocycle, which optionally is substituted at least once by linear or branched (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-acyl, (C.sub.1 -C.sub.8)-alkoxy, (C.sub.2 -C.sub.8)-alkoxyalkyl and/or the carbocycle optionally containing at least one heteroatom selected from the group consisting of N, O, P and S in the ring;R.sup.8 is H or a radical B-X-Z, wherein B is a radical selected from the group consisting of CR.sup.9.sub.2, NR.sup.9, O, S or SiR.sup.9.sub.2, X is a spacer selected from the group consisting of 1,4'-biphenyl, 1- or 2-ethylene, 1- or 3-propylene and PEG-(2-10) and Z is a radical bonded to a polymer via a functional group selected from the group consisting of O--, NH--, COO--, CONH, ethenyl, NHCONH--, OCONH-- and NHCOO--;or the residues R.sup.8 of the two cyclopentadienyl rings are bonded to each other via an .alpha.,.omega.-(C.sub.2 -C.sub.4)-alkylene bridge; andR.sup.9 is H or (C.sub.1 -C.sub.18)-alkyl.