Patent ID: 6211211
Filing Date: 2001-04-03
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I) or pharmaceutically acceptable salt thereof: ##STR10##wherein:P is a ring system selected from the following: ##STR11##wherein; ##STR12##and the other variables are as defined below: ##STR13##in which either a and b together represent a bond or CH.sub.2 or a and b together represent a carbonyl group, a group C.dbd.NOR.sup.F, CHOR.sup.F or ##STR14##where R.sup.F is hydrogen or C.sub.1-6 alkyl; or ##STR15##in which either J is nitrogen and J.sup.a is a lone pair of electrons, M is carbon and M.sup.a is R.sub.5 ; orJ is carbon and M is nitrogen and J.sup.a and M.sup.a are hydrogen; or ##STR16##in which Z is oxygen or CH.sub.2 ; and; ##STR17##wherein:either Y is N and R.sub.2 is hydrogen, or Y is C--R.sub.1 and where:either one of R.sub.1 and R.sub.2 is hydrogen and the other is selected from the class of hydrogen, C.sub.3-8 cycloalkyl, C.sub.1-6 alkyl optionally interrupted by oxygen or substituted by hydroxy, C.sub.1-6 alkoxy or substituted aminocarbonyl, C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkylcarbonyloxy, C.sub.1-6 alkoxy, nitro, cyano, halo, trifluoromethyl, CF.sub.3 S, or a group CF.sub.3 --A--, where A is --CF.sub.2 --, --CO--, --CH.sub.2 --, CH(OH), SO.sub.2, SO, CH.sub.2 --O, or CONH, or a group CF.sub.2 H--A'-- where A' is oxygen, sulphur, SO, SO.sub.2, CF.sub.2 or CFH; trifluoromethoxy, C.sub.1-6 alkylsulphinyl, perfluoro C.sub.2-6 alkylsulphonyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkoxysulphinyl, C.sub.1-6 alkoxysulphonyl, aryl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, phosphono, arylcarbonyloxy, heteroarylcarbonyloxy, arylsulphinyl, heteroarylsulphinyl, arylsulphonyl, heteroarylsulphonyl in which any aromatic moiety is optionally substituted, C.sub.1-6 alkylcarbonylamino, C.sub.1-6 alkoxycarbonylamino, C.sub.1-6 alkyl-thiocarbonyl, C.sub.1-6 alkoxy-thiocarbonyl, C.sub.1-6 alkyl-thiocarbonyloxy, 1-mercapto C.sub.2-7 alkyl, formyl, or aminosulphinyl, aminosulphonyl or aminocarbonyl, any amino moiety being optionally substituted by one or two C.sub.1-6 alkyl groups, or C.sub.1-6 alkylsulphinylamino, C.sub.1-6 alkylsulphonylamino, C.sub.1-6 alkoxysulphinylamino or C.sub.1-6 alkoxysulphonylamino, or ethylenyl terminally substituted by C.sub.1-6 alkylcarbonyl, nitro or cyano, or --C(C.sub.1-6 alkyl)NOH or --C(C.sub.1-6 alkyl)NNH.sub.2, or one of R.sub.1 and R.sub.2 is nitro, cyano or C.sub.1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by one or two C.sub.1-6 alkyl or by C.sub.2-7 alkanoyl; or R.sub.1 and R.sub.2 together are --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.dbd.CH--, or form an optionally substituted triazole or oxadiazole ring;one of R.sub.3 and R.sub.4 is hydrogen or C.sub.1-4 alkyl and the other is C.sub.1-4 alkyl, CF.sub.3 or CH.sub.2 X.sup.a where X.sup.a is fluoro, chloro, bromo, iodo, C.sub.1-4 alkoxy, hydroxy, C.sub.1-4 alkylcarbonyloxy, --S--C.sub.1-4 alkyl, nitro, amino optionally substituted by one or two C.sub.1-4 alkyl groups; cyano or C.sub.1-4 alkoxycarbonyl or R.sub.3 and R.sub.4 together are C.sub.2-5 polymethylene optionally substituted by C.sub.1-4 alkyl;R.sub.5 is C.sub.1-6 alkylcarbonyloxy, benzoyloxy, ONO.sub.2, benzyloxy, phenyloxy or C.sub.1-6 alkoxy and R.sub.6 and R.sub.9 are hydrogen or R.sub.5 is hydroxy and R.sub.6 is hydrogen or C.sub.1-2 alkyl and R.sub.9 is hydrogen;R.sub.7 is benzo-2,1,3-oxadiazole, benzoylphenyl or 2-phenoxyphenyl;R.sub.8 is hydrogen; C.sub.1-6 alkyl, OR.sub.9 or NHCOR.sub.10 wherein R.sub.9 is hydrogen, C.sub.1-6 alkyl, formyl, C.sub.1-6 alkanoyl, aroyl or aryl-C.sub.1-6 alkyl and R.sub.10 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, mono or di C.sub.1-6 alkyl amino, amino, amino-C.sub.1-6 alkyl, hydroxy-C.sub.1-6 alkyl, halo-C.sub.1-6 alkyl, C.sub.1-6 acyloxy-C.sub.1-6 alkyl, C.sub.1-6 alkoxycarbonyl-C.sub.1-6 -alkyl, aryl or heteroaryl;the R.sub.8 --N--CO--R.sub.7 group being cis or trans to the R.sub.5 group;and X is oxygen or NR.sub.11 where R.sub.11 is hydrogen or C.sub.1-6 alkyl.