Patent ID: 6831193
Filing Date: 2004-12-14
Classification: C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, whereinA1 and A2 are each independently selected from the group consisting of alkoxycarbonyl, alkylcarbonyloxy, carboxy, hydroxy, hydroxyalkyl, (NRARB)carbonyl, â€”NRCS(O)2RD, â€”S(O)2OH; or A3 is selected from the group consisting of alkoxycarbonyl, alkylcarbonyloxy, carboxy, hydroxy, hydroxyalkyl, (NRARB)carbonyl, NRCS(O)2RD, â€”S(O)2OH; A4, A5, A6 and A7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkenyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkynyl, aryl, carboxy, cyano, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, â€”NRERF and (NRERF)carbonyl; A8, A9, A10 and A11 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkenyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkynyl, aryl, carboxy, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, â€”NRERF and (NRERF)carbonyl and oxo; RA and RB are each independently selected from the group consisting of hydrogen, alkyl and cyano; RC is selected from the group consisting of hydrogen and alkyl; RD is selected from the group consisting of alkoxy, alkyl, aryl, arylalkoxy, arylalkyl, haloalkoxy and haloalkyl; RE and RF are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, formyl, and hydroxyalkyl; L1 is selected from the group consisting of alkenylene, alkylene, alkynylene, â€”(CH2)mO(CH2)nâ€”, â€”(CH2)mS(CH2)nâ€” and â€”(CH2)pC(O)(CH2)qâ€” wherein each group is drawn with the left end attached to N and the right end attached to R1; m is an integer 0-10; n is an integer 0-10; R1 is selected from the group consisting of aryl, cycloalkenyl, and cycloalkyl; L2 is absent or selected from the group consisting of a covalent bond, alkenylene, alkylene, alkynylene, â€”(CH2)pO(CH2)qâ€”, â€”(CH2)pS(CH2)qâ€”, â€”(CH2)pC(O)(CH2)qâ€”, â€”(CH2)pC(OH)(CH2)qâ€” and â€”(CH2)pCH&boxH;NO(CH2)qâ€” wherein each group is drawn with the left end attached to R1 and the right end attached to R2; p is an integer 0-10; q is an integer 0-10; and R2 is absent or selected from the group consisting of aryl, cycloalkenyl, and cycloalkyl.