Patent ID: 6809110
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinX is N and Y is S; or X is S and Y is N; R1 is aryl or heteroaryl; R2 is hydrogen, lower-alkyl or fluoro-lower-alkyl; R3, R4, R5 and R6 independently from each other are selected from hydrogen, hydroxy, lower-alkenyl, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, hydroxy-lower-alkoxy, and lower-alkoxy-lower-alkoxy, wherein at least one of R3, R4, R5 and R6 is not hydrogen, or R3 and R4 are bonded to each other to form a ring together with the carbon atoms to which they are attached, and R3 and R4 together are â€”CH&boxH;CHâ€”Sâ€”, â€”Sâ€”CH&boxH;CHâ€”, â€”CH&boxH;CHâ€”Oâ€”, â€”Oâ€”CH&boxH;CHâ€”, â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, â€”(CH2)3-5â€”, â€”Oâ€”(CH2)2-3â€” or â€”(CH2)2-3â€”Oâ€”, and R5 and R6 are as defined above; R7 is lower-alkyl, lower-alkoxy, lower-alkenyloxy, aryloxy or aryl-lower-alkoxy; R8 is hydrogen or lower-alkyl; R9 and R10 independently from each other are hydrogen, lower-alkyl, lower-alkenyl, cycloalkyl, phenyl or [1,3]dioxan-2-ethyl; n is 1, 2 or 3; or a pharmaceutically acceptable salt or a pharmaceutically acceptable ester thereof.