Patent ID: 6011058
Filing Date: 2000-01-04
Classification: C07B,C07C,C07D

Abstract:
A compound of the formula (I) ##STR6## wherein: R.sub.1 is selected from the group consisting of H, lower alkyl, and alkoxy;R.sub.2 is selected from the group consisting of C1-C10 alkyl, substituted C1-C10 alkyl, C2-C10 alkene containing one to four double bonds, substituted C2-C10 alkene, and C1-C10 alkyl or C2-C10 alkene having one or more heteroatoms selected from the group consisting of oxygen atoms and nitrogen atoms inserted into the chain thereof, the chain having 10 or less atoms including the hetero atoms;R.sub.3 is selected from the group consisting of methylene, ketone, and methyl;R.sub.4 is absent when R.sub.3 is methylene or ketone, or when R.sub.3 is methyl, R.sub.4 is selected from the group consisting of hydrogen, lower alkyl, alkoxy, lower alkanoyloxy, hydroxy, carboxyl, amino, lower alkylamino, and halo, or R.sub.4 is an oxygen atom which together with the C10 atom to which R.sub.4 is attached and R.sub.5 consists of a heterocyclic ring and the double bond between C10 and R.sub.3, C9 and C10, or C10 and R.sub.5 is absent;Y is selected from the group consisting of C1-C6 alkyl and C2-C6 alkene, said C1-C6 alkyl or C2-C6 alkene terminating in an amide group --CONH.sub.2, a nitrile group --CN or an acid group selected from the group consisting of carboxylic acids, sulfonic acids, carbodithioic acids and phosphoric acids, or salts thereof, orY is --(CH.sub.2).sub.n --C(O)--X--, wherein n is an integer from 1 to 3, X is oxygen or nitrogen, and together with C8 atom to which Y is attached, the C9 atom, and the C10 atom constitute a ring system comprising a 6 to 8 membered lactone or lactam ring, orY is --(CH.sub.2)--C(O)--O--, and together with the C8 atom to which Y is attached, the C9 atom, the C10 atom, and R.sub.5 constitute a ring system consisting of a lactone ring when R.sub.3 is methyl, R.sub.4 is hydroxyl and the double bond between C10 and R.sub.3, R.sub.5 and C10 or C9 and C10 is absent;R.sub.5 is selected from the group consisting of C2-C8 alkyl, C2-C8 alkene having one or more double bonds, substituted C2-C8 alkyl, and substituted C2-C8 alkene;R.sub.6 is a functional group selected from the group consisting of CN, COOH, CHO, CH.sub.2 OH, CONH.sub.2, CSSH, or salts of these acid groups, and CONR.sub.2, wherein R is lower alkyl, acyl or H, and optionally a hydrogen atom of a carbon atom adjacent R.sub.6 is replaced with an identical functional group; andthe broken lines indicate optional double bonds, and pharmaceutically acceptable salts thereof.