Patent ID: 6495517
Filing Date: 2002-12-17
Classification: A61K,A61P,C07C

Abstract:
A method of inhibiting cyclooxygenase-2 in a host, which comprises administering to a host in need thereof an effective amount of a compound having the formula (1) or (1â€²): wherein R1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; R2 is a hydrogen atom, a hydroxyl group, an organothiol group that is bound to the selenium atom by its sulfur atom, or R1 and R2 are joined to each other by a single bond; R3 is a hydrogen atom, a halogen atom, an alkyl group having 1-3 carbon atoms, an alkoxyl group having 1-3 carbon atoms, a trifluoromethyl group, or a nitro group; R4 and R5 are identical to or different from each other, and each is a hydrogen atom, a halogen atom, an alkoxyl group having 1-4 carbon atoms, a trifluoromethyl group, or R4 and R5 are joined to each other to form a methylenedioxy group, a salt thereof, or a hydrate thereof.