Patent ID: 6620936
Filing Date: 2003-09-16
Classification: A61P,C07D,Y02P

Abstract:
A compound of the general formula (I) wherein A is hydrogen or (wherein X is oxygen or sulfur, R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, amino, hydroxy, C1-C4 lower alkylhydroxy, C1-C4 lower alkylamino, C1-C8 alkyl, C1-C4 lower alkoxy or C1-C4 lower alkyloxycarbonyl and m and n are independently an integer of 0, 1 or 2), R6, R7, R8 and R9 are independently C1-C8 alkyl or C1-C4 lower alkoxy, and Y is hydrogen, amino, â€”N&boxH;CHRâ€² (wherein Râ€² is hydrogen, benzyl, C1-C8 alkyl or C1-C6 lower alkylamino), (wherein Râ€³ is hydrogen, benzyl, C1-C8 alkyl or C1-C6 lower alkylamino, and Râ€²â€³ is hydrogen, benzyl, C1-C8 alkyl or amino protecting group) or wherein, X is as defined above, R1â€², R2â€², R3â€², R4â€² and R5â€² are independently hydrogen, halogen, nitro, amino, hydroxy, C1-C4 lower alkylhydroxy, C1-C4 lower alkylamino, C1-C8 alkyl, C1-C4 lower alkoxy or C1-C4 lower alkylcarboxy, and m and n are independently an integer of 0, 1 or 2) or its pharmaceutically acceptable salt, wherein A and Y are not H at the same time, and when Y is amino group, A is not H.