Patent ID: 9145397
Filing Date: 2015-09-29
Classification: A61P,C07D

Abstract:
1. A process for the preparation of 1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzylcarbamoyl)-L-proline-N,N-dimethylamide, comprising the steps of: i) adding 1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)-benzylcarbamoyl)-L-proline-N,N-dimethylamide to an organic solvent; ii) heating the mixture until an emulsion is formed; iii) cooling the emulsion until a clear solution is obtained; iv) stirring the clear solution until a suspension is obtained; and v) isolating the resulting crystalline form of 1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzylcarhamoyl)-L-proline-N, N-dimethylamide.