Patent ID: 6515124
Filing Date: 2003-02-04
Classification: A61P,C07B,C07C,C07D,C07F

Abstract:
A compound of formula: wherein R1 is hydrogen, hydroxy, amino or halogen, R2 is hydrogen, hydroxy, or halogen and R3 is hydrogen; A is R4 and R5 are hydrogen, methyl, ethyl or halogen except that R4 and R5 cannot both be hydrogen; and 1) B is hydrogen, or lower alkyl; or 2) B is where R6 R7 R8 and R9 are independently hydrogen, hydroxy, aminosulfonyl, halogen, lower alkoxy, cyano, amino, lower alkyl, lower alkyl amino, or nitro; or 3) B is where R10 is hydrogen, hydroxy, halogen, or lower alkyl and C is a five- or six-membered ring with 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur, which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalkyl, amino, or substituted amino; or 4) B is â€ƒwhere X and Y are independently methylene or nitrogen; or 5) B is where at least one of T, U, V, or W is nitrogen, and any of T, U, V or W which is carbon may be substituted with lower alkyl, lower alkyl amino, lower alkoxy, hydroxy, aminosulfonyl, halogen, cyano, amino, or nitro; or 6) B is wherein Y is carbon or nitrogen; or 7) B is a five-membered aromatic ring with 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalkyl, trifluoroloweralkyl, amino, halogen, substituted amino, or which ring may be fused with a 5 or 6 membered aromatic ring containing 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur; or pharmaceutically acceptable salts thereof.