Patent ID: 6017953
Filing Date: 2000-01-25
Classification: A61K,A61P,C07D

Abstract:
A compound of formula II useful as a thromboxane ligand, ##STR8## wherein Y is (CH.sub.2).sub.x ; Z is selected from the group consisting of O, OCH.sub.2, ##STR9## and (CR.sub.2).sub.x, x is an integer of 1 or 2; R.sub.2 is hydrogen or an alkyl radical of from 1 to 4 carbons, A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxo or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur atoms, or substituted derivatives of said methyl, cycloalkyl or aryl radicals wherein said substituent is selected from the group consisting of halo, nitro, amino, thiol, hydroxy, alkyloxy and alkylcarboxy; and X is selected from the group consisting of cyano, --COOR, --CH.sub.2 OR, --C(O)N(R.sub.2), --CH.sub.2 N(R.sub.2) --CH.dbd.N--OH and --CH.sub.2 SR.sub.1 radicals wherein R is hydrogen or a C.sub.1 to C.sub.10 alkyl, phenyl or benzyl and E is O or S; or a pharmaceutically acceptable salt thereof.