Patent ID: 7951921
Filing Date: 2011-05-31
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A composition comprising a tetravalent targetable complex comprising the structure (IgG1) 2 -(scFv) 4 ; wherein said tetravalent targetable complex is formed by linking two IgG1-(scFv) 2 molecules with a structure having the composition (Ac-Cys-Lys(DTPA)-Tyr-Lys(DTPA)-NH 2 ) 2 , wherein each IgG1-(scFv) 2 molecule comprises a pair of heavy chains and a pair of light chains, wherein each heavy chain comprises a humanized, chimeric or human IgG1 heavy chain and an scFv, wherein said scFv is fused to the C-terminus of said IgG1 heavy chain, wherein said scFv binds to DTPA and wherein greater than 75% of the complexes in the composition have a stoichiometry of two molecules of IgG1-(scFv), and one molecule of (Ac-Cys-Lys(DTPA)-Tyr-Lys(DTPA)-NH 2 ) 2 .