Patent ID: 6670377
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A quinoline compound or its salt, according to general formula I in whichRa, Rb and Rc, identical or different from one another, represent one or more substituents, themselves identical or different, occupying any position on the rings, the substituents being chosen from a â€”(CH2)nâ€”Y or â€”CH&boxH;CHâ€”Y group, where Y represents a halogen atom, an â€”OH, â€”OR, â€”COH, â€”COR, â€”COOH, â€”COOR, â€”COH, â€”COR, â€”CONH2, â€”CON(Rx, Ry), â€”CH&boxH;NOH, â€”COâ€”CH&boxH;NOH, â€”NH2, â€”N(Rx, Ry), â€”NO2, â€”PO(OR)2, â€”SH2, â€”SR, â€”SO2R, â€”SO2NHR, â€”CN, or Z(Rc) radical, where R represents an alkyl radical with 1 to 8 carbon atoms, or an aryl or heterocyclic radical, Rx and Ry, identical or different, represent an alkyl radical with 1 to 5 carbon atoms, Z represents an aryl or heterocyclic radical and n is zero or an integer from 1 to 5, Rb moreover can represent a hydrogen atom, and when Y represents a â€”COOH or â€”COOR group in Rc, Z, if it represents an aryl group, includes at least 3 substituents or the quinoline ring is trisubstituted, X represents an ethylene double bond, or a â€”(CH2)nâ€” group, where n is an integer from 1 to 5, or a â€”CH(Rd)â€”CH(Re)â€” group, Rd and Re, identical or different, representing a hydrogen atom, halogen atom, a hydroxy or epoxy group, or a â€”(CH2)nâ€²â€”Oâ€”C(O)â€”(CH2)mâ€”, â€”(CH2)nâ€²â€”C(O)â€”Oâ€”(CH2)mâ€”, â€”(CH2)nâ€²â€”Oâ€”(CH2)mâ€”, â€”(CH2)nâ€²â€”N(Q)â€”(CH2)mâ€” or â€”(CH2)nâ€²â€”S(O)tâ€”(CH2)mâ€” group, where nâ€² is an integer from 0 to 8, m is an integer from 0 to 8, t is zero or an integer equal to 1 or 2, and Q represents a hydrogen atom, an alkyl or aryl radical, as well as the pharmaceutically acceptable salts of these derivatives, their diastereoisomeric forms and their enantiomeric forms.