Patent ID: 6166051
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A compound of formula ##STR5## wherein R is a mercapto group or a R.sub.4 COS group convertible in the organism to mercapto group;R.sub.1 is a straight or branched C.sub.2 -C.sub.4 alkyl group or an aryl or arylalkyl group with from 1 to 6 carbon atoms in the alkyl moiety wherein the aryl is a phenyl or a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted with one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl alkylthio, alkylsuphonyl or alkoxycarbonyl groups with from 1 to 6 carbon atoms in the alkyl moiety, C.sub.1 -C.sub.3 alkyl groups containing one or more fluorine atoms, carboxy groups, nitro groups, amino or aminocarbonyl groups, acylamino groups, aminosulphonyl groups, mono- or di-alkylamino or mono- or di-alkylaminocarbonyl groups with from 1 to 6 carbon atoms in the alkyl moiety;R.sub.2 is a hydrogen atom, a straight or branched C.sub.1 -C.sub.4 alkyl group or a benzyl group;R.sub.3 is a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted with a phenyl group, being the phenyl and the heterocyclic group optionally substituted with one or more substituents, the same or different, selected among halogen atoms, alkyl alkoxy, alkylthio or alkoxycarbonyl groups with from 1 to 3 carbon atoms in the alkyl moiety;R.sub.4 is a straight or branched C.sub.1 -C.sub.4 alkyl group or a phenyl group;the carbon atoms marked with an asterisk are stereogenic centers;and pharmaceutically acceptable salts thereof;provided that R.sub.3 is not an imidazolyl, furyl, thienyl, benzofuryl, benzothienyl or indolyl group.