Patent ID: 8232383
Filing Date: 2012-07-31
Classification: A61K,A61P,C07H,C12N

Abstract:
1. A chemically modified nucleic acid molecule that mediates RNA interference, wherein: (a) the nucleic acid molecule comprises a sense strand and a separate antisense strand; (b) each strand of the nucleic acid molecule is independently 18 to 24 nucleotides in length; (c) the antisense strand is complementary to a target RNA sequence; (d) the sense strand includes a terminal cap moiety at its 5′- and 3′-ends; and (e) all pyrimidine nucleotides of the sense strand and the antisense strand are chemically modified with 2′-deoxy, 2′-O-methyl, or 2′-deoxy-2′-fluoro nucleotides.