Patent ID: 6200993
Filing Date: 2001-03-13
Classification: A61P,C07D

Abstract:
A compound represented by formula I: ##STR43##or a pharmaceutically acceptable salt or hydrate thereof wherein:Y represents N or N-oxide;R.sup.1 and R.sup.2 are independently selected from: H, C.sub.1-6 alkyl and haloC.sub.1-6 alkyl,R.sup.3 and R.sup.4 are independently selected from H and C.sub.1-6 alkyl, or R.sup.3 and R.sup.4 attached to the same carbon atom are taken together and represent a carbonyl oxygen atom, orR.sup.3 and R.sup.4 attached to different carbon atoms considered in combination with the carbon atoms to which they are attached along with any intervening atoms and represent a saturated 5, 6 or 7 membered carbocyclic ring,R.sup.5 is present or absent;when present, R.sup.5 represents a member selected from the group consisting of: H, C.sub.1-6 alkyl, C(O)C.sub.1-6 alkyl, C(O)Ar.sup.1, CO.sub.2 C.sub.1-6 alkyl, CO.sub.2 Ar.sup.1, or an oxide oxygen atom, the alkyl portions of which are optionally substituted with 1-3 halo, hydroxy, C.sub.1-4 alkyl or with one aryl group selected from phenyl, thienyl, thiazolyl, pyridyl and naphthyl;or R.sup.5 is taken in combination with one R.sup.3 group that is present, and represents along with the R.sup.3 group and any intervening atoms a 5-6 membered heterocyclic ring,or R.sup.5 is taken with a substituent on Ar.sup.1 and represents a 5-6 membered heterocyclic ring fused to Ar.sup.1 ;when R.sup.5 is absent, the dotted line represents a bond and the carbon atom to which it is attached does not contain an R.sup.3 group;R.sup.6 and R.sup.7 are independently selected from the group consisting of: H, halo, C.sub.1-6 alkyl, haloC.sub.1-6 alkyl and CN;n represents an integer of from 0-6;each Ar.sup.1 is independently selected from the group consisting of:(a) thienyl,(b) thiazolyl,(c) pyridyl,(d) phenyl and(e) naphthyl,each Ar.sup.1 being optionally substituted with 1-3 members selected from the group consisting of:(1) halo,(2) C.sub.1-6 alkoxy,(3) C.sub.1-7 alkylthio,(4) CN,(5) C.sub.1-6 alkyl,(6) C.sub.1-6 hydroxyalkyl,(7) --CO.sub.2 H, --CO.sub.2 C.sub.1-6 alkyl,(8) NH(SO.sub.2 Me), N(SO.sub.2 Me).sub.2,(9) SO.sub.2 Me,(10) NO,(11) C.sub.1-6 alkenyl,(12) halo C.sub.1-6 alkyl, and(13) NH.sub.2,and when Ar.sup.1 represents a phenyl or naphthyl group with two or three substituents, two such substituents may be considered in combination and represent a 5 or 6 membered fused lactone ring.