Patent ID: 8710089
Filing Date: 2014-04-29
Classification: A61K,A61P,C07D

Abstract:
1. A method for increasing or decreasing growth hormone levels in a mammal or for increasing or decreasing food intake of a mammal comprising: administering to a mammal in need of treatment at least one compound according to formula (I): wherein: R1 and R2 are independently of one another a hydrogen atom or are selected from the group of radicals consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, and arylalkylsulfonyl; wherein said radicals at R1 or R2 are optionally substituted in an alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and/or heterocyclylalkyl group by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N R3 is selected from the group of radicals consisting of alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -alkyl-O-aryl, -alkyl-O-arylalkyl, -alkyl-O-heteroaryl, -alkyl-O-heteroarylalkyl, -alkyl-O-heterocyclyl, alkyl-O-heterocyclylalkyl, -alkyl-CO-aryl, -alkyl-CO-arylalkyl, -alkyl-CO-heteroaryl, -alkyl-CO-heteroarylalkyl, -alkyl-CO-heterocyclyl, -alkyl-CO-heterocyclylalkyl, -alkyl-C(O)O-aryl, -alkyl-C(O)O-arylalkyl, -alkyl-C(O)O-heteroaryl, -alkyl-C(O)O-heteroarylalkyl, -alkyl-C(O)O-heterocyclyl, -alkyl-C(O)O-heterocyclylalkyl, -alkyl-CO—NH wherein said radicals are optionally substituted in the aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and/or heterocyclylalkyl group by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N R4 is hydrogen; R5 is a radical a) selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, —CO-alkyl, —CO-cycloalkyl, —CO-cycloalkylalkyl, —CO-aryl, and —CO-arylalkyl, wherein said radical from (a) is optionally substituted by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N b) selected from the group consisting of —CO-heteroaryl, —CO-heteroarylalkyl, —CO-heterocyclyl, —CO-heterocyclylalkyl, wherein said radical from (b) is optionally substituted by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N R6 is hydrogen; R7 and R8 are independently of one another selected from the group consisting of a hydrogen atom, alkyl, cycloalkyl, and cycloalkylalkyl; and m is 0; wherein * designates a carbon atom of R or S configuration when chiral.