Patent ID: 6703481
Filing Date: 2004-03-09
Classification: C07K

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof, whereinA1 is deleted; A3 is an aromatic amino acid; A6 is Thr, Thr(Bzl), Gly, Ser, an Eaa or an aliphatic amino acid; A8 is a D- or L-isomer selected from the group consisting of Thr, Ser, an aromatic amino acid and an aliphatic amino acid; R1 is substituted or unsubstituted E1CO wherein E1 is aryl, aryl lower alkyl, heterocycle or heterocycle lower alkyl; and R3 is OH, NH2, C1-12 alkoxy or NHâ€”Yâ€”CH2â€”Z, wherein Y is a C1-12 hydrocarbon moiety and Z is H, OH, CO2H or CONH2; or R3, together with the carbonyl group of A8 attached thereto, are reduced to form H, lower alkyl or hydroxy lower alkyl; provided that a disulfide bond links the sidechains of A2 and A7.