Patent ID: 6143744
Filing Date: 2000-11-07
Classification: C07C,C07D

Abstract:
A compound selected from the group of compounds represented by formula (I): ##STR41## wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl; or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a carbocycle or a heterocycle;R.sup.3 is hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, (diphenylmethyl)alkyl, or -(alkylene)-C(O)-X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl; or R.sup.3 together with either R.sup.1 or R.sup.2 and the atoms to which they are attached forms a heterocycloamino group;R.sup.10 is --NR.sup.11 OR.sup.12 wherein:R.sup.11 and R.sup.12 are independently selected from hydrogen, alkyl, or aralkyl;R.sup.20 and R.sup.21 are independently selected from hydrogen, alkyl, heteroalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaralkyl, or heteroaralkenyl; or R.sup.20 and R.sup.21 together with the nitrogen atom to which they are attached form a heterocycloamino group or an optionally substituted tetrahydropyridine or hexahydroazepine ring; or either of R.sup.20 or R.sup.21 together with R.sup.3 forms an alkylene group; andtheir pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers, provided that R.sup.20 and R.sup.21 together with the nitrogen atom to which they are attached do not form a morpholino ring either:(i) when R.sup.1 and R.sup.3 are hydrogen and R.sup.2 is aralkyl; or(ii) when R.sup.1 and R.sup.3 together with the atoms to which they are attached form a tetrahydroisoquinoline ring and R.sup.2 is hydrogen.