Patent ID: 6723698
Filing Date: 2004-04-20
Classification: A01N,A61F,A61K,A61L,C07K,G01N

Abstract:
A method of treating a mammal with symptoms of amyotrophic lateral sclerosis (ALS), comprising administering to said mammal a morphogen, wherein the morphogen:(1) comprises a dimeric protein having an amino acid sequence with: (a) at least 70% homology with the C-terminal seven-cysteine skeleton of human OP-1, residues 330-431 of SEQ ID NO: 2; or, (b) greater than 60% amino acid sequence identity with said C-terminal seven-cysteine skeleton of human OP-1; and (2) stimulates production of an N-CAM or L1 isoform by an NG108-15 cell in vitro; whereby motor function is improved in said mammal.