Patent ID: 7651681
Filing Date: 2010-01-26
Classification: A61F,A61K,A61L,A61P

Abstract:
1. The method of forming a film in situ upon a mucosal tissue that is wet or moist, comprising: providing a liquid composition comprising, 1) a volatile solvent; and 2) a water soluble polymer selected from the group consisting of carboxymethylcellulose, and hydroxyethyl cellulose, the water soluble polymer being capable of attaching to a hydrophobic group through covalent bonding; 3) a compound selected from the group consisting of octadecyl isocyanate, hydroxysuccinimide, perfluoro-1-octanesulfonyl fluoride, palmitoyl chloride, and fatty acid chloride; wherein preparation and use of the liquid composition includes steps of modifying the water solubility of the polymer in the liquid composition by attaching a hydrophobic group of the compound selected from the group consisting of octadecyl isocyanate, hydroxysuccinimide, perfluoro-1-octanesulfonyl fluoride, palmitoyl chloride, and fatty acid chloride to the water soluble polymer to produce a water insoluble interaction product; applying the liquid composition to a mucosal tissue that is wet or moist; evaporating the solvent from the liquid composition in situ; and forming a film which adheres to a mucosal tissue that is wet or moist.