Patent ID: 6555580
Filing Date: 2003-04-29
Classification: A61P,C07C,C07D

Abstract:
Compounds of the general formula (I) in whichR1 represents nitro, amino, acetamido or represents a group of the formula â€”NHâ€”COâ€”COâ€”A or â€”NHâ€”CH2â€”COâ€”A, in which A represents hydroxyl or (C1-C4)-alkoxy, R2 and R3 are identical or different and denote halogen, C1-C4-alkyl or trifluoromethyl, R4 represents a group of the formula â€ƒin which E represents straight-chain or branched (C1-C4)-alkyl, R6 and R7 are identical or different and, independently of one another, represent straight-chain or branched (C1-C10)-alkyl which can be substituted one or more times, identically or differently, by (C3-C8)-cycloalkyl, (C1-C6)-alkoxy, amino, mono- or di-(C1-C6)-alkylamino, (C1-C4-alkoxycarbonylamino, aminocarbonyl, (C1-C6)-alkoxycarbonyl, or by (C6-C10)-aryl, where aryl is optionally substituted one or more times, identically or differently, by (C1-C4)-alkyl, aminocarbonyl, (C1-C4)-alkanoylamino or halogen, or represent (C6-C10)-aryl or (C3-C8)-cycloalkyl, each of which can be substituted by (C1-C4)-alkoxy, R8 represents straight-chain or branched (C1-C10)-alkyl which can be substituted by (C3-C8)-cycloalkyl, phenyl or phenoxy, or represents (C3-C8)-cycloalkyl, (C6-C10)-aryl, biphenylyl or (C1-C6)-alkoxy, R9 represents straight-chain or branched (C1-C8)-alkyl whose carbon chain can be interrupted by â€”Oâ€” and which can be substituted by (C3-C8)-cycloalkyl or phenyl, or represents (C3-C8)-cycloalkyl, (C2-C6)-alkenyl, or phenyl, where the aromatic ring systems mentioned both in R8 and in can, in each case independently of one another, in turn be substituted by trifluoromethyl, halogen, (C1-C4)-alkoxy, (C1-C4)-alkyl or amino, R10 represents straight-chain or branched (C1-C15)-alkyl which can be substituted by (C3-Cg)-cycloalkyl, (C1-C4)-alkoxy, phenyl, phenoxy or benzyloxy, where the said aromatic radicals can in turn each be substituted up to three times, identically or differently, by halogen, (C1-C6)-alkyl or (C1-C4)-alkoxy, represents (C3-C8)-cycloalkyl which can be substituted by (C1-C4)-alkoxy or phenyl, represents (C6-C10)-aryl which can be substituted up to three times, identically or differently, by (C1-C6)-alkyl, (C1-C6)-alkoxy, halogen, cyano, amino, trifluoromethyl or phenyl, or denotes a group of the formula â€”OR13 or NR14R15, in which â€ƒR13 represents straight-chain or branched (C1-C6)-alkyl, and â€ƒR14 and R15 are identical or different and, independently of one another, represent hydrogen, straight-chain or branched (C1-C12)-alkyl, which can be substituted by aminocarbonyl, a group of the formula â€”NR16R17, or can be substituted by phenyl, where phenyl is optionally substituted up to twice, identically or differently, by halogen, (C1-C4)-alkyl, trifluoromethyl or (C1-C4)-alkoxy, represent (C3-C8)-cycloalkyl which can be substituted by (C1-C4)-alkyl, or represent (C6-C10)-aryl which can be substituted up to three times, identically or differently, by halogen, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy, amino, phenyl or phenoxy, where R16 and R17 are identical or different and, independently of one another, represent hydrogen, (C1-C6)-alkyl, phenyl or arylsulphonyl, R11 and R12 are identical or different and, independently of one another, represent hydrogen, straight-chain or branched (C1-C6)-alkyl, which can be substituted one or more times, identically or differently, by mono-(C1-)-alkylamino, di-(C1-C6)-alkylamino, (C1-C4)-alkoxy, (C1-6)-alkoxycarbonyl, carboxyl, or (C6-C10)-aryl, where the latter in turn is optionally substituted by halogen, trifluoromethyl, (C1-C6)-alkyl or (C1-C6)-alkoxy, represent (C3-C8)-cycloalkyl where cycloalkyl is optionally substituted by (C1-C4)-alkyl, R5 denotes hydrogen, (C1-C4)-alkyl or (C1-C4)-alkanoyl, and the respective salts and hydrates thereof.