Patent ID: 8530232
Filing Date: 2013-09-10
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
1. A pharmaceutical formulation for treating a mammal suffering from a tumor that expresses higher levels of high affinity laminin receptors than normal cells of the same lineage comprising a Mut-4 defective Sindbis viral vector and a heterologous anti-tumor gene selected form the group consisting of a suicide gene, an apoptosis-inducing gene, a tumor suppressor gene, an oncogene antagonist gene, an immunostimulatory gene, a tumor suppressor effector gene, an antisense oligonucleotide-encoding sequence, a ribozyme-encoding sequence, and an immunogenic peptide-encoding sequence and a pharmaceutically acceptable carrier or diluent wherein said Mut-4 defective Sindbis viral vector comprises: Sindbis structural proteins capsid 6k, E1, E2 and E3 encoded by nucleotides 1-6711 as set forth in SEQ ID NO.: 39, and a replicon plasmid comprising nucleotides 1-9928 as set forth in SEQ ID NO.: 36 encoding the viral replicase.