Patent ID: 7683031
Filing Date: 2010-03-23
Classification: C07K,G01N

Abstract:
1. A compound which has the property of modulation of signal transduction of a seven transmembrane (7TM) receptor consisting of: at least one moiety for transport across cellular membranes, in association with a peptide sequence of 5-20 amino acid residues selected from the group consisting of: (a) a peptide sequence which is a continuous stretch of at least 5 amino acids present in the 7TM receptor in positions corresponding to the positions 143-151 of bovine rhodopsin when the 2 (b) a variant of the peptide sequence according to (a) wherein up to 40% of the amino acids of the native sequence have been replaced with a naturally or non-naturally occurring amino acid or with a peptidomimetic moiety; and/or up to 40% of the amino acids have their side chains chemically modified; and/or up to 20% of the amino acids have been deleted, provided that, when the 2 (c) a peptide sequence according to (a) or (b) wherein at least one of the amino acids is replaced with a corresponding D-amino acid; (d) a peptide sequence according to any one of (a)-(c) wherein at least one of the peptidic backbones has been altered to a non-naturally occurring peptidic backbone; (e) a peptide sequence being the sequence of any one of (a)-(d) in reverse order; and (f) a combination of two or more of the peptide sequences of (a) to (e).