Patent ID: 6737423
Filing Date: 2004-05-18
Classification: A61P,C07D

Abstract:
A substituted heterocyclo-norbornylamino compound having an exo-configuration nitrogen and endo-fused five-membered or six-membered ring of the formula I or having an exo-configuration nitrogen and exo-fused five-membered or six-membered ring of the formula I a, wherein:A is (C1-C4)-alkylene; T is (C1-C4)-alkyl or H; B is a saturated or unsaturated carbon five-membered or six-membered ring, which is unsubstituted or is substituted by 1-3 substituents chosen from oxo, hydroxyl, (C1-C4)-alkoxy, and (C1-C4)-alkyl; Het is a 5- or 6-membered, saturated or unsaturated, heterocycle that contains up to four identical or different heteroatoms chosen from O, S, N, and Se; R is OH, F, Cl, Br, I, CN, NO2, phenyl, CO2R1, (C1-C4)-alkyl, (C1-C4)-alkoxy, amino, (C1-C4)-alkylamino, di(C1-C4)-alkylamino, or amino-(C1-C4)-alkyl, wherein the alkyl radicals are unsubstituted or are completely or partly substituted by fluorine; R1 is H or (C1-C4)-alkyl, which is unsubstituted or completely or partly substituted by fluorine; n is 0, 1, 2, 3 or 4, wherein, if n=2, 3 or 4, the substituents R are chosen independently of one another; or a pharmaceutically tolerable salt or trifluoracetate thereof.