Patent ID: 8834838
Filing Date: 2014-09-16
Classification: A61K,A61P,C07F

Abstract:
1. A method of diagnosing the existence of a disease state or condition in tissue of a patient in which levels of LFA-1 or ICAM receptors are suspected of being elevated comprising administering to said patient an effective amount of at least one compound according to the following chemical structure: Where Y is a chemical linker which links the nitrogen to a chelate group or tricarbonyl complex X, wherein X incorporates or complexes with a radioisotope, or a pharmaceutically acceptable salt thereof, measuring the amount of said compound which binds to said tissue in said patient, and comparing said measurement from said measuring step with a standard, wherein an elevated measurement in comparison to said standard is indicative of the existence of said disease state or condition in said patient and said disease state or condition is an inflammatory or immune cell-mediated disease, ischemia-reperfusion injury, reperfusion injury of tissue due to cardiopulmonary bypass, myocardial infarction, acute glomerulonephritis, vasculitis, reactive arthritis, dermatosis, stroke, thermal injury, hemodialysis, ulcerative colitis, necrotizing enterocolitis, solid organ transplant rejection, an autoimmune disease or a hyperproliferative disease.