Patent ID: 8377957
Filing Date: 2013-02-19
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: wherein: R R Ar is selected from the group consisting of aryl and heteroaryl each of which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, methylenedioxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, amino, alkylamino, and dialkylamino; Ar′ is selected from the group consisting of arylene and heteroarylene each of which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, amino, alkylamino, and dialkylamino; Het is heterocyclyl which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, hydroxyalkyleneoxyalkylenyl, amino, alkylamino, dialkylamino, and oxo; X R Y is selected from the group consisting of: —CH(—N(—O—R R R R R R R R A is selected from the group consisting of —CH A′ is selected from the group consisting of —O—, —S(O) Q is selected from the group consisting of a bond, —C(R V is selected from the group consisting of —C(R W is selected from the group consisting of a bond, —C(O)—, and —S(O) a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7; or a pharmaceutically acceptable salt thereof.