Patent ID: 6177087
Filing Date: 2001-01-23
Classification: A61K,C07K,C08G,Y10S

Abstract:
A method of treatment comprising administering to a mammal in need thereof a therapeutically effective amount of a polymer conjugate comprising the formula:[R--B'--W--L.sup.1 ].sub.z -(nucleolphile)wherein:(R) is a water soluble substantially non-antigenic polvmer residue:(B') is a secondary or tertiary amine;when B' is a tertiary amine, (W) is a spacer moietv selected from the group consisting of straight or branched C.sub.1-4 alkyls, aralkyls, aryls, heteroarwl moieties, C(O)NHCH.sub.2 CH.sub.2 C(O) and CH.sub.2 (O);when B' is a secondary amine, (W) is selected from the group consisting of aralkyls, aryls, heteroaryl moieties, C(O)NHCH.sub.2 CH.sub.2 C(O) and CH.sub.2 C(O);(nucleophile) is a member of the group consisting of proteins and chemotherapeutic agents;(L.sup.1) represents a covalent linkage between R--B'--W) and the nucleophile; and(z) represents the number of polymers attached to the nucleophile.