Patent ID: 7449449
Filing Date: 2008-11-11
Classification: A61K,A61P,C07K,C12M,C12N

Abstract:
1. An agent for genetically transforming tissue cells of a living vertebrate, said agent comprising microparticles coated with stabilizing agent and carrying a polynucleotide sequence, said polynucleotide sequence comprising, in the 5′ to 3′ direction, (1) a regulatory sequence operable in vertebrate tissue; and positioned downstream of said regulatory sequence and under the transcriptional control thereof, (2) a nucleotide sequence encoding a protein or peptide immunogen from a vertebrate pathogen against which an immune response is desired, wherein upon expression of said nucleotide sequence encoding the protein or peptide immunogen in the tissue cells, said vertebrate exhibits an immune response to said protein or peptide immunogen.