Patent ID: 6579892
Filing Date: 2003-06-17
Classification: A61P,C07D

Abstract:
A triazole compound of the formula I whereR1 is H, C1-C6-alkyl, which may be substituted by OH, OC1-C6-alkyl, halogen or phenyl, C3-C6-cycloalkyl or phenyl; R2 is H, C1-C6-alkyl, which may be substituted by OH, OC1-C6-alkyl, halogen or phenyl, C1-C6-alkoxy, C1-C6-alkylthio, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, halogen, CN, COOR3, CONR3R4, NR3R4, SO2R3, SO2NR3R4 or an aromatic radical which is selected from phenyl, naphthyl and a 5- or 6-membered heterocyclic radical having 1, 2, 3 or 4 heteroatoms which are selected, independently of each other, from O, N and S, with it being possible for the aromatic radical to have one or two substituents which are selected, independently of each other, from C1-C6-alkyl, which may be substituted by OH, OC1-C6-alkyl, halogen or phenyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, halogen, CN, COR3, NR3R4, NO2, SO2R3, SO2NR3R4 and phenyl which may be substituted by one or two radicals which are selected, independently of each other, from C1-C6-alkyl, C1-C6-alkoxy, NR3R4, CN, CF3, CHF2 or halogen; R3 and R4 are, independently of each other, H, C1-C6-alkyl, which may be substituted by OH, OC1-C6-alkyl, halogen or phenyl, or phenyl; A is C4-C10-alkylene or C3-C10-alkylene which comprises at least one group Z which is selected from O, S, CONR3, COO, CO, C3-C6-cycloalkyl and a double or triple bond; B is a radical of the following formula: â€ƒwhere X is CH2 or CH2CH2; R5 is H, C1-C6-alkyl, which may be substituted by OH, OC1-C6-alkyl, halogen or phenyl, C3-C6-cycloalkyl, C2-C6-alkenyl, which may be substituted by halogen, or C2-C6-alkynyl; R6, R7 and R8 are, independently of each other, selected from H, OH, C1-C6-alkoxy, SH, C1-C6-alkylthio, C2-C6-alkenyl, C2-C6-alkynyl, halogen, CN, NO2, SO2R3, SO2NR3R4, NHSO2R3, NR3R4, and C1-C6-alkyl which is optionally substituted by OH, OC1-C6-alkyl, C1-C6-alkylthio, halogen or phenyl; or a salt thereof with a physiologically tolerated acid.