Patent ID: 7754227
Filing Date: 2010-07-13
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A human vaccine composition comprising an immunologically effective amount of a molecular conjugate of S. typhi Vi polysaccharide covalently bound through a carboxylic acid dihydrazide linker to Pseudomonas aeruginosa recombinant exoprotein A, in a pharmaceutically acceptable carrier, wherein the S. typhi Vi polysaccharide is a linear homopolymer of α(1→4)-D-GalpA, which is N-acetylated at C-2 and O-acetylated at C-3, wherein the carboxylic acid dihydrazide linker is selected from succinic acid dihydrazide, suberic acid dihydrazide, or sebacic acid dihydrazide.