Patent ID: 7192967
Filing Date: 2007-03-20
Classification: A61P,C07D

Abstract:
1. An imide-substituted pyridylalkane, alkene and alkine acid amide of formula (I) wherein the substituents have the following meanings: R R R R k is 0 or 1, A is selected from D is selected from E is a cyclic imide of the formula whereby these cyclic imides can be substituted by one to five of the same or different groups selected independently from each other from halogen, cyano, alkyl, alkylidene, trifluoromethyl, cycloalkyl, cycloalkylidene, phenylalkyl, phenylalkylidene, diphenylalkyl, diphenylalkylidene, triphenylmethyl, aryl, hydroxy, hydroxyalkyl, alkoxy, alkoxy entirely or partially substituted by fluorine, aralkyloxy, aryloxy, naphthyloxy, mercapto, alkylthio, arylthio, heteroarylthio, alkanesulfonyl, arylsulfonyl, heteroarylsulfonyl, sulfo, carboxy, carboxyalkyl, carboxyalkenyl, alkoxycarbonyl, aralkyloxycarbonyl, nitro, amino, aminoalkyl, mono-alkylamino, di-(alkyl)amino, arylamino, arylalkylamino, heteroarylamino, saturated or unsaturated, four- to seven-membered heterocycles which can contain one or two hetero-atoms selected from N and/or S and/or O and are either bound directly or bound over a methylene group or a methine group, monocyclic aromatic five- or six-membered heterocycles which can contain one to three hetero-atoms selected from N and/or S and/or O and are either bound directly or bound over a methylene group or a methine group, anellated bicyclic, aromatic or partially hydrogenated carbocyclic ring systems with 8 to 12 ring atoms which are either bound directly or bound over a methylene or a methine group, anellated bicyclic aromatic or partially hydrogenated heterocyclic ring systems with 8 to 12 ring atoms, whereby one to three ring atoms can be selected from N and/or S and/or O and are either bound directly or bound over a methylene or a methine group, and whereby aryl and heteroaryl residues as substituents of the cyclic imides can be substituted themselves by one to three of the same or different groups selected from halogen, cyano, alkyl, trifluoromethyl, cycloalkyl, aralkyl, aryl, hydroxy, hydroxyalkyl, alkoxy, alkoxy entirely or partially substituted by fluorine, aralkyloxy, aryloxy, mercapto, alkylthio, arylthio, carboxy, carboxyalkyl, carboxyalkenyl, alkoxycarbonyl, aralkyloxycarbonyl, nitro, amino, aminoalkyl, mono-alkylamino, di-(alkyl)amino and, for two adjacent residues, methylenedioxy; the cis- and trans-isomer, E- and Z-isomer of the above defined compound, the enantiomer, diastereomer and other isomer of the above defined compound, and their racemic and/or non-racemic mixtures, and the pure endo- and/or exo-isomers of the above defined compound in the case that the imide ring system is bicyclic, and their mixture; the tautomeric compound in the optional case that E contains a heterocyclic aromatic ring with simultaneous substitution by free hydroxy, mercapto or amino groups; or the acid addition salt, hydrate or solvate of the above defined compound.