Patent ID: 6255343
Filing Date: 2001-07-03
Classification: A61P,C07C

Abstract:
A composition for the treatment of dry eye and other disorders requiring the wetting of the eye comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of one or more compounds of the following formula I: ##STR9##R.sup.1 is CO.sub.2 R, CONR.sup.2 R.sup.3, CH.sub.2 OR.sup.4, CH.sub.2 NR.sup.5 R.sup.6, CH.sub.2 N.sub.3, CH.sub.2 Hal, CH.sub.2 NO.sub.2, CH.sub.2 SR.sup.20, COSR.sup.21 or 2,3,4,5-tetrazol-1-yl, wherein:R is H or CO.sub.2 R forms a pharmaceutically acceptable salt or a pharmaceutically acceptable ester;NR.sup.2 R.sup.3 and NR.sup.5 R.sup.6 are the same or different and comprise a free or functionally modified amino group;OR.sup.4 comprises a free or functionally modified hydroxy group;Hal is F, Cl, Br or I;SR.sup.20 comprises a free or functionally modified thiol group;R.sup.21 is H or COSR.sup.21 forms a pharmaceutically acceptable salt or a pharmaceutically acceptable thioester;A, B, C and D are the same or different and are C.sub.1 -C.sub.5 alkyl, alkenyl, or alkynyl or a C.sub.3 -C.sub.5 allenyl group;X is C(O) or X is ##STR10##wherein R.sup.9 O constitutes a free or functionally modified hydroxy group.