Patent ID: 7022846
Filing Date: 2006-04-04
Classification: A61P,C07D,Y10T

Abstract:
1. A process for synthesizing a compound of formula 11, N-hydroxy-4-(4-((1-oxy-pyrid-4-yl)oxy)benzenesulfonyl)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxamide, comprising the steps of: (i) protecting a compound of formula 1  with a protecting group, P (ii) activating the compound of formula 2 with an activating agent, A (iii) coupling the compound of formula 3 with a compound of formula 4 having an ester, E  to form a compound of formula 5 (v) removing the protecting group, P (vi) coupling the compound of formula 6 with p-nitro pyridine N-oxide, a compound of formula 7  to form a compound of formula 8 (vii) removing the ester, E (vii) activating the compound of formula 9 with an activating agent, A (viii) treating the compound of formula 10 with hydroxylamine to form the compound of formula 11