Patent ID: 6458782
Filing Date: 2002-10-01
Classification: A61K,A61P,C07D,Y10S

Abstract:
A method for the therapeutic treatment of diabetes comprising:administering to a mammal an amount of a medicament effective to treat the diabetes, the medicament comprising as an active ingredient a compound having formula (I): â€ƒor a compound having formula (II): wherein R1 represents hydrogen atom or C1-6 alkyl group; R2 and R3 independently represent hydrogen atom or C1-6 alkyl group, or R2 and R3 may combine together with the carbon atoms of the phenyl ring to which R2 and R3 bind to represent a 5- or 6-membered ring which may optionally be substituted with one or more C1-4 alkyl groups; R4 represents hydrogen atom, C1-6 alkyl group, C1-6 alkoxyl group, hydroxyl group, nitro group, or halogen atom; R5 represents hydrogen atom, C1-6 alkyl group, or aryl-substituted C1-6 alkyl group; R6 represents hydrogen atom or C1-6 alkyl group; X represents â€”NR7â€”, â€”NOâ€”, â€”Oâ€”, â€”CHR7â€”, â€”Sâ€”, â€”SOâ€” or â€”SO2â€” in which R7 represents hydrogen atom, C1-6 alkyl group, or aryl-substituted C1-6 alkyl group; and Y represents a phenylene group or a pyridinediyl group, a physiologically acceptable salt thereof, and a hydrate thereof and a solvate thereof.