Patent ID: 9120862
Filing Date: 2015-09-01
Classification: A61P,C07K,G01N

Abstract:
1. A method of detecting PIVKA-II antigen in a test sample, the method comprising the steps of: a) contacting the test sample with a monoclonal antibody having an antigen binding portion that binds to an epitope within amino acids 1-13 of PIVKA-II and for a time and under conditions sufficient for the formation of monoclonal antibody-antigen complexes; and b) detecting the presence of the monoclonal antibody-antigen complexes, wherein the presence of the monoclonal antibody-antigen complexes indicates the presence of PIVKA-II in the test sample, wherein the monoclonal antibody is a monoclonal antibody produced by a hybridoma cell line having ATCC deposit designation PTA-10541.