Patent ID: 6624307
Filing Date: 2003-09-23
Classification: C07D

Abstract:
A process for the production of 2,6-dihydroxy-3,4-dialkylpyridine having the formula wherein R1 and R2 are independently H, C1-C4 alkyl or aryl, comprising the steps of:reacting 2-cyanoacetamide in alcohol with alkali metal methoxide to produce a slurry; adding with mixing ethyl 2-alkylacetoacetate to the slurry; filtering the slurry and washing the filtrate with alcohol to obtain the sodium salt of 2,6-dihydroxy-4,5-dialkyl-3-pyridinecarbonitrile; adding hydrobromic acid to the sodium salt of 2,6-dihydroxy-4,5-dialkyl-3-pyridinecarbonitrile to obtain a homogeneous solution; cooling the solution to obtain a crystallized solid of 2,6-dihydroxy-3,4-diakylpyridine hydrobromide salt; and washing the crystallized solid of 2,6-dihydroxy-3,4-dialkylpyridine hydrobromide salt with an alkali, water and alcohol to obtain the 2,6-dihydroxy-3,4-dialkylpyridine.