Patent ID: 6747057
Filing Date: 2004-06-08
Classification: A61P,C07C,C07D

Abstract:
A method of treatment of a disease mediated by the activation of GSK-3 in a subject in need thereof the method comprising administering to the subject an effective amount of a compound of formula (I): wherein:X represents â€”Sâ€”, â€”SOâ€”, or â€”SO2; Y1, Y2 and Y3 independently represent hydrogen or halogen; R1, R2 and R3 are independently represent hydrogen, halogen, hydrocarbyl (â€”R), hydroxyl (â€”OH), hydrocarbyloxy (â€”0â€”R), mercapto (â€”SH), hydrocarbylthio (â€”Sâ€”R), hydrocarbylsulfinyl (â€”SOâ€”R), hydrocarbylsulfonyl (â€”SO2â€”R), nitro (â€”NO2), amino (â€”NH2), hydrocarbylaniino (â€”NHR), bis(hydrocarbyl)amino (â€”NR2), hydrocarbylcarbonylamino (â€”NHâ€”COâ€”R), cyano (â€”CN), carbarnoyl (â€”CONH2) hydrocarbylcarbarnoyl (â€”CONHR), bis(hydrocarbyl)carbarnoyl (â€”CONH2), carboxyl (â€”C02H), hydrocarbyloxycarbonyl (â€”CO2R), formyl (â€”CHO), hydrocarbylcarbonyl (â€”COR), hydrocarbylcarbonyloxy (â€”OCOR), optionally substituted heteroarvi or optionally substituted heterocyclic; and the hydrocarbyl group R is a straight or branched chain hvdrocarbvl aroup selected from alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl and aralkynyl, which may optionally be substituted by one or more substituents, selected from those defined above in relation to R1, R2 and R3, or a pharmaceutical composition thereof.