Patent ID: 6652864
Filing Date: 2003-11-25
Classification: A61K,A61P,Y10T

Abstract:
A method for delivering a non-cytotoxic antiviral therapeutic moiety selectively into nerve cells, the method comprising:administering a compound having the general formula: Bâ€”Lâ€”TM â€ƒwhere: B is nerve growth factor (NGF) or a fragment thereof which selectively binds to a neurotrophin receptor; TM is a noncytotoxic, antiviral therapeutic moiety other than a nerve growth factor or fragment thereof; and L is an enzymatically cleavable amide linker coupling B to TM, wherein binding of moiety B to a nerve cell neurotrophin receptor triggers absorption of the receptor-bound compound and delivery of the non-cytotoxic therapeutic moiety into the nerve cell.