Patent ID: 6800640
Filing Date: 2004-10-05
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I whereinW is SO2; X is N or CR1; Y is N or CR2; Z is N or CR3; Q is N or CR4with the proviso that one of X, Y, Z and Q is N; n is an integer of 2 or 3; R1, R2, R3 and R4 are each independently H, halogen, CN, OCO2R13, CO2R14, CONR15R16, CNR17NR18R19, SOmR20, NR21R22, OR23, COR24 or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R5 and R6 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted, or R5 and R6 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom selected from O, N or S; R7 and R8 are each independently H or an optionally substituted C1-C6alkyl group; R9 is H, halogen, or a C1-C6alkyl, C1-C6alkoxy, aryl or heteroaryl group each optionally substituted; R10 is an optionally substituted C1-C6alkyl, aryl, or heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S with the proviso that when Q is N and X, Y and Z are CH then R10 must be other than unsubstituted phenyl; m is 0 or an integer of 1 or 2; R13, R14, R20, R23 and R24 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R15, and R16 are each independently H or an optionally substituted C1-C6alkyl group; and R17, R18, R19, R21 and R22 are each independently H or an optionally substituted C1-C4alkyl group; or R21 and R22 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, N or S; or a stereoisomer thereof or a pharmaceutically acceptable salt thereof.