Patent ID: 6025401
Filing Date: 2000-02-15
Classification: G01N

Abstract:
A method for treating a mammal to inhibit the formation of advanced glycosylation end products of an amino-containing peptide, protein or biomolecule within said mammal, said method comprising administering to said mammal an effective amount of a pharmaceutical composition, said pharmaceutical composition comprising an agent capable of reacting with the glycosyl-amino moiety of the early glycosylation product (also know as the Amadori product or Heyns product) formed by the reaction of glucose, or other reactive sugars, with said amino-containing peptide, protein or biomolecule, thus stabilizing this early glycosylation product, and preventing its further reaction to form open-carbonyl-containing advanced glycosylation endproducts, wherein said method is adapted for the treatment of diabetic kidney disease, glomerulosclerosis, peripheral vascular disease, peripheral neuropathy, retinopathy, periarticular rigidity, or stiffening of joints.