Patent ID: 8288564
Filing Date: 2012-10-16
Classification: A61P,C07D

Abstract:
1. A process for production of a trans-dibenzoxenopyrrole compound represented by general formula (VI): wherein X 1 and X 2 are the same or different and each independently represents hydrogen or a halogen atom, or a pharmacologically acceptable salt thereof, the process comprising the following steps A-D: Step A: A step in which a compound represented by general formula (II): wherein R represents an alkyl group optionally substituted with a phenyl group, and X 1 and X 2 have the same definitions as above; is reduced to obtain a compound represented by general formula (III): wherein X 1 and X 2 have the same definitions as above; Step B: A step of leaving group conversion of a compound represented by general formula (III) to obtain a compound represented by general formula (IV): wherein X 1 and X 2 have the same definitions as above, and Y represents a leaving group; Step C: A step in which a compound represented by general formula (IV) is subjected to hydrogenation to obtain a trans-dibenzoxenopyrrole compound represented by general formula (V): wherein X 1 and X 2 have the same definitions as above; and Step D: A step in which a trans-dibenzoxenopyrrole compound represented by general formula (V) is methylated to obtain a trans-dibenzoxenopyrrole compound represented by general formula (VI).