Patent ID: 8957093
Filing Date: 2015-02-17
Classification: A61P,C07D

Abstract:
1. A method of inhibiting kinase-mediated phosphorylation of PPARG in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein: R is H or (C R R 3 is mono- or multi-substituted arylalkyl, wherein each substituent on R 3 is independently selected from the group consisting of (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 6 -C 10 )aryl, (C 3 -C 9 )cycloalkyl, 3-9 membered mono- and bicyclic heterocyclyl, 3-9 membered mono- and bicyclic heteroaryl, halo, haloalkyl, haloalkoxy, nitro, cyano, CO 2 R′, methylenedioxy, OR′, N(R′) 2 , C(O)N(R′) 2 , (C 1 -C 4 )alkyl-S(O) q , SO 2 NR′ 2 , and (C 1 -C 6 )alkoxyl, wherein R′ is independently H, (C each of X Z is a group of formula wherein a wavy line indicates a point of attachment, each X 5 -X 7 is independently N or is C substituted with an independently selected H or R 4 ; provided that no more than one of X 5 -X 7 is N; each R R″ is H, or (C q is 0, 1 or 2; R R