Patent ID: 6344547
Filing Date: 2002-02-05
Classification: A61K,C12N,Y10S

Abstract:
An isolated nucleic acid molecule comprising a nucleotide sequence encoding an amino acid sequence selected from the group consisting of:(a) an amino acid sequence at least 95% identical to SEQ ID NO:2, wherein said amino acid sequence has human MutT2 activity; (b) an amino acid sequence at least 95% identical to SEQ ID NO:2, wherein said amino acid sequence is recognized by an antibody which specifically binds human MutT2; (c) the amino acid sequence of a polypeptide fragment of SEQ ID NO:2, wherein said fragment has human MutT2 activity; (d) the amino acid sequence of an antigenic fragment of SEQ ID NO:2, wherein said fragment is recognized by an antibody which specifically binds human MutT2; (e) the amino acid sequence of a polypeptide fragment comprising Gly-Glu-Thr-Pro-Glu and Arg-Glu-Leu-Glu-Glu-Glu domains of SEQ ID NO:2, wherein said fragment has human MutT2 activity; (f) the amino acid sequence of a polypeptide fragment comprising Gly-Glu-Thr-Pro-Glu and Arg-Glu-Leu-Glu-Glu-Glu domains of SEQ ID NO:2, wherein said fragment is recognized by an antibody which specifically binds human MutT2; (g) an amino acid sequence of at least 30 contiguous amino acids of SEQ ID NO:2, wherein said amino acid sequence has human MutT2 activity; and (h) an amino acid sequence of at least 30 contiguous amino acids of SEQ ID NO:2, wherein said amino acid sequence is recognized by an antibody which specifically binds human MutT2.