Patent ID: 6677378
Filing Date: 2004-01-13
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula wherein phenyl ring A and phenyl ring B can each, independently, be replaced by a naphthyl group, and wherein when phenyl ring A is replaced by a naphthyl group, the ethereal oxygen of structure I and the carbon to which R3, R4 and NR1R2 are attached, are attached to adjacent ring carbon atoms of the naphthyl group and neither of said adjacent ring carbon atoms is also adjacent to a fused ring carbon atom of said naphthyl group;n and m are, selected, independently, from one, two and three; R1 and R2 are selected, independently, from hydrogen, (C1-C4)alkyl, (C2-C4)alkenyl, and (C2-C4)alkynyl; R3 and R4 are selected, independently, from hydrogen and (C1-C4)alkyl optionally substituted with from one to three fluorine atoms, or R3 and R4 together with the carbon to which they are attached, form a four to eight membered saturated carbocyclic ring, and wherein said ring may optionally be substituted at available binding sites with from one to three substituents selected, independently, from hydroxy and (C1-C6)alkyl; each X is selected, independently, from hydrogen, chloro, fluoro, bromo or lodo, (C1-C4)alkyl optionally substituted with from one to three fluorine atoms, (C1-C4)alkoxy optionally substituted with from one to three fluorine atoms, cyano, nitro, amino, (C1-C4)alkylamino, di-[(C1-C4)alkyl]amino, NR5(C&boxH;O)(C1-C4)alkyl, SO2NR5R6 and SOp(C1-C8)alkyl, wherein R5 and R6 are selected, independently, from hydrogen and (C1-C6)alkyl, and p is zero, one or two; and each Y is selected, independently, from hydrogen, (C1-C6)alkyl and halo; with the proviso that; at least one X must be other than hydrogen when (i) R3 and R4 are both hydrogen, (ii) R1 and R2 are selected, independently, from hydrogen and (C1-C4)alkyl, and (iii) ring B is mono- or disubstituted with, respectively, one or two halo groups; or a pharmaceutically acceptable salt thereof.