Patent ID: 9051279
Filing Date: 2015-06-09
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), or pharmaceutically acceptable salt thereof, wherein Z is N—R X is halogen; R H— C R H— R′O— (R′) R R′O— (R′) each R′ is independently selected from the group consisting of H— C C halo-C halo-C C heterocyclyl- aryl- hydroxy-C C amino-C N—C N,N-di-C C heterocyclyl-C aryl-C C halo-C hydroxy-C C amino-C N—C N,N-di-C C heterocyclyl-C aryl-C C heterocyclyl-carbonyl- aryl-carbonyl- C halo-C hydroxy-C C amino-C N—C N,N-di-C C heterocyclyl-carbonyl-C aryl-carbonyl-C carbonyl-C hydroxy-carbonyl-C C amino-carbonyl-C N—C N,N-di-C C heterocyclyl-carbonyl-C aryl-carbonyl-C C C halo-C halo-C each R halogen- cyano- nitro- C C halo-C hydroxy- C amino- N—C N,N-di-C amino-carbonyl-amino- N—C N,N-di-C C amino-carbonyl- N—C N,N-di-C hydroxy-C amino-C N—C N,N-di-C C C n is 0 to 2; R and wherein said phenyl, 2-pyridyl or 3-pyridyl is optionally substituted by 1-2 additional substituents selected from or Or Or wherein each R (R (R R R R R R (R C hydroxycarbonyl-C amino-carbonyl-C R (R R aryl-C heterocyclyl-C C halo-C heterocyclyl-carbonyl- aryl-carbonyl- C C heterocyclyl- aryl- or two R halogen- hydroxy-C C halo-C oxo= hydroxy- C amino- N—C N,N-di-C hydroxy-carbonyl- C amino-carbonyl- N—C N,N-di-C C each R with the proviso that if Z is CH then R aryl means phenyl or naphthyl, and heterocyclyl means an unsaturated, saturated, or partially saturated ring or ring system comprising 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 ring atoms, and containing at least one heteroatom selected from N, O and S, where the N and S can also optionally be oxidized, and wherein, unless otherwise stated, the heterocyclic group can be attached at a heteroatom or a carbon atom.