Patent ID: 8834874
Filing Date: 2014-09-16
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A fusion antibody comprising: (a) an immunoglobulin that crosses a blood brain barrier (BBB), wherein the immunoglobulin comprises an immunoglobulin heavy chain and an immunoglobulin light chain; and (b) an iduronate-2-sulfatase, wherein the amino acid sequence of the iduronate-2-sulfatase is covalently linked to the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain, thereby forming a fusion protein; wherein the fusion antibody crosses the blood brain barrier (BBB) and catalyzes hydrolysis of 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate or heparin and wherein the iduronate-2-sulfatase retains at least 20% of its activity compared to its activity as a separate entity.