Patent ID: 6818656
Filing Date: 2004-11-16
Classification: A61K

Abstract:
A pharmaceutical composition in unit dosage form adapted for administration to a subject suffering from irritable bowel syndrome comprising an amount of at least one salt of a polyamine with a pharmaceutically accepted acid therapeutically effective to treat irritable bowel syndrome and a pharmaceutically acceptable carrier therefore, said polyamine being selected from the group consisting of polyamines having the formula:1) Râ€”NHâ€”(CH2)aâ€”NHâ€”(CH2)bHâ€”(CH2)câ€”NH2, 2) CF3â€”C6H5â€”(CH2)aâ€”NHâ€”(CH2)bâ€”NHâ€”(CH2)câ€”NHâ€”(CH2)dâ€”NHâ€”(CH2)eâ€”C6H5â€”CF3, 3) Râ€”NHâ€”(CH2)aâ€”NHâ€”C6H10â€”NHâ€”(CH2)bâ€”NHâ€”R and4) PIPâ€”(CH2)aNHâ€”(CH2)bâ€”NHâ€”(CH2)câ€”PIP, wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to 10 about carbon atoms, and any of said alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10.