Patent ID: 7452878
Filing Date: 2008-11-18
Classification: A61K,A61P,A61Q,C07C,C07D

Abstract:
1. A biaromatic compound having the structural formula (I): in which: R is a hydrogen atom; R R wherein R 9 is as defined below; R R R s and t have the values 0, 1 or 2; Z is an oxygen, nitrogen or sulfur atom; R R wherein R 10 , R′ and R″ are as defined below; R′ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical or a hydroxyl radical; R″ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, optionally substituted with one or more halogen atoms, a heteroaryl radical, a heterocyclic radical or a radical (CH R R R A is a radical having the following structure: wherein D, w, x, y, z and R 13 are as defined below; D is an oxygen or sulfur atom, a radical —NR R x, y and z, which may be identical or different, have the values 0 or 1; w has a value from 0 to 6 with the proviso that w is equal to 0 or 1 when D is oxygen, and R R in which: R3=OMe and R′3=R″3=H; R3=OMe, R′3=OMe and R″3=H; and R3=H and R′3=R″3=OMe; also other than the compounds of formula (III) below: in which: z=1 and x=0; and z=0 and x=1; and also other than the compounds of formula (IV) below: in which: p=1, X is an oxygen atom, R5 is a benzyl radical and R4 is a 2-benzimidazole or 4-pyridine radical; p=1, X is an oxygen atom, R5 is an ethyl radical and R4 is a 2-pyridine, 3-pyridine, 4-pyridine or methyl radical; p=1, X is an oxygen atom, R4 is a propyl radical and R5 is an ethyl, CH p=1, X is an NH radical, R4 is a propyl radical and R5 is a hydrogen atom or a benzyl radical; p=1, X is an NH radical, and R4 and R5 are each a cyclohexyl radical; and p=0, R4 is an ethyl radical and R5 is a 4-methoxyphenyl radical.