Patent ID: 6316623
Filing Date: 2001-11-13
Classification: C07D

Abstract:
A compound of formula: ##STR35##wherein:R.sub.1 and R.sub.2 are independently H or a hydrocarbyl group selected from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.20 alkynyl, C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 aralkyl, C.sub.3 -C.sub.14 cycloalkyl, C.sub.5 -C.sub.14 fused cycloalkyl, C.sub.4 -C.sub.14 heterocyclyl, C.sub.4 -C.sub.14 heterocycloalkyl, C.sub.4 -C.sub.14 heteroaryl, C.sub.4 -C.sub.14 heteroarylalkyl, and CH(R.sub.2)--NH--R.sub.2 ; wherein said hydrocarbyl group is optionally substituted with acyl, alkoxy, alkoxycarbonyl, alkyl, alkenyl, alkynyl, amino, amido, azido, aryl, heteroaryl, carboxylic acid, cyano, guanidino, halo, haloalkyl, haloalkoxy, hydrazino, hydroxyl, alkylsulfonyl, nitro, sulfide, sulfone, sulfonate, sulfonamide, thiol or thioalkoxy;R.sub.3, R.sub.4, and R.sub.5 are independently H, an amino protecting group, or a divalent group selected from CH.sub.2, CH(R.sub.2), C.dbd.O, C.dbd.S, S(.dbd.O).sub.2, C(.dbd.O)NH, C(.dbd.S)NH or C(.dbd.O)O; wherein said divalent group is substituted with H or ahydrocarbyl group selected from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.20 alkynyl, C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 aralkyl, C.sub.3 -C.sub.14 cycloalkyl, C.sub.5 -C.sub.14 fused cycloalkyl, C.sub.4 -C.sub.14 heterocyclyl, C.sub.4 -C.sub.14 heterocyclylalkyl, C.sub.4 -C.sub.14 heteroaryl, C.sub.4 -C.sub.14 heteroarylalkyl or CH(R.sub.2)--NH--R.sub.2 ; wherin said hydrocarbyl group is optionally substituted with oxo, acyl, alkoxy, alkoxycarbonyl, alkyl, alkenyl, alkynyl, amino, amido, azido, aryl, heteroaryl, carboxylic acid, cyano, guanidino, halo, haloalkyl, haloalkoxy, hydrazino, hydroxyl, alkylsulfonyl, nitro, sulfide, sulfone, sulfonate, sulfonamide, thiol, and thioalkoxy;R.sub.6 is H or a solid support.