Patent ID: 9125895
Filing Date: 2015-09-08
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating a coagulopathy in a subject in need thereof, comprising administering to the subject a therapeutically effective dose of an anti-Factor XI (FXI) antibody or biologically active fragment thereof, wherein the antibody or biologically active fragment thereof comprises: (a) a variable heavy (VH) domain comprising three complementarity determining regions (CDRs), wherein the three CDRs comprise the amino acid sequences of SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12; and (b) a variable light (VL) domain comprising three CDRs, wherein the three CDRs comprise the amino acid sequences of SEQ ID NO: 13, SEQ ID NO: 14 and SEQ ID NO: 15.