Patent ID: 6372222
Filing Date: 2002-04-16
Classification: A61K,A61P,C08B,Y10S

Abstract:
A conjugate molecule comprising at least one polysaccharide fragment covalently bound to a protein wherein the at least one polysaccharide fragment is selected from the group consisting of Group B streptococcus type II and type III polysaccharide fragments, wherein the Group B streptococcus type II and/or type III polysaccharide fragment is obtained by a process comprising partial de-N-acetylation and depolymerization by deamination, and wherein the fragment is covalently bound to a protein wherein the conjugate molecule has the structure wherein for the type II fragment R1 is H and R2 is sialylated heptasaccharide repeating-unit of formula wherein n is about 5 to about 50, and where for the type III fragment R1 is sialylated pentasaccharide repeating-unit of formula wherein n is about 5 to 50 and R2 is a disaccharide &agr;NemNAc(2-3)&bgr;-D-Galpâ†“-.