Patent ID: 8212081
Filing Date: 2012-07-03
Classification: C07C

Abstract:
1. A process for preparing a substituted 1,4-quinone methide of formula (I) wherein comprising: reacting a 3,5-disubstituted 4-hydroxybenzaldehyde of formula (II) and an alcohol and/or thioalcohol ((thio)alcohol) of formula (IV) wherein in the presence of a at least one catalyst selected from the group consisting of a free or solid-phase-bound organic sulphonic acid, sulphuric acid, a hydrogensulphate, an organic or inorganic phosphorus acid, a dihydrogen or hydrogen salt of an organic or inorganic phosphorous acid, fuming nitric acid and boric acid, to obtain a (thio)acetal; and eliminating the alcohol or thiol from the obtained (thio)acetal to yield the substituted 1,4-quinone methide of formula (I).