Patent ID: 7838699
Filing Date: 2010-11-23
Classification: A61K

Abstract:
1. A method of embolizing a vascular site in a mammal, comprising the step of: introducing into the vasculature of a mammal a microparticle comprising a hydrolytically degradable crosslinked hydrogel, thereby embolizing a vascular site of said mammal; wherein said hydrolytically degradable crosslinked hydrogel comprises a crosslink derived from a compound selected from the group consisting of a compound of formula 1 and a compound of formula 2; the compound of formula 1 is represented by: wherein X represents independently for each occurrence O or S; L represents independently for each occurrence —NH—O—Q, or —O—NH—Q; Q represents independently for each occurrence acryloyl, 2-alkylacryloyl, 3-alkylacryloyl, 2,3-dialkylacryloyl, 3,3-dialkylacryloyl, 2,3,3-trialkylacryloyl, acryloylO(CR R represents independently for each occurrence H or alkyl; Z represents (CR Ar represents independently for each occurrence aryl or heteroaryl; J represents independently for each occurrence O, S, NR, cycloalkyl, heterocyclyl, (CH n represents independently for each occurrence an integer in the range 1-10; and m represents independently for each occurrence an integer in the range 0-10; and the compound of formula 2 is represented by: wherein X represents independently for each occurrence O or S; M represents independently for each occurrence —NH—O—Q, or —O—NH—Q; Q represents independently for each occurrence acryloyl, 2-alkylacryloyl, 3-alkylacryloyl, 2,3-dialkylacryloyl, 3,3-dialkylacryloyl, 2,3,3-trialkylacryloyl, acryloylO(CR R represents independently for each occurrence H or alkyl; Z represents (CR Ar represents independently for each occurrence aryl or heteroaryl; J represents independently for each occurrence O, S, NR, cycloalkyl, heterocyclyl, (CH G represents (CR n represents independently for each occurrence an integer in the range 1-10; and t represents 3 or 4.