Patent ID: 6608087
Filing Date: 2003-08-19
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of formula IA: or a pharmaceutically acceptable salt thereof, whereinR1 is an optionally substituted group selected from a C1-6 aliphatic group, â€”C(R4)2(CH2)nNRCOR, â€”C(R4)&boxH;Nâ€”OR, â€”C(R4)&boxH;Nâ€”OC(&boxH;O)(C1-6 aliphatic), â€”C(R4)&boxH;NNRCO2(C1-6 aliphatic), â€”C(R4)&boxH;NNRCOR, â€”C(R4)&boxH;NN(R)2, â€”C(R4)2 (CH2)nNRCO2(C1-6 aliphatic), â€”CO2(C1-6 aliphatic), â€”CON(R)2, â€”C(R4)2(CH2)nCON(R)2, â€”C(R4)2(CH2)nSO2N(R)2, â€”CONHâ€”OR, â€”SO2N(R)2, or â€”C(R4)2(CH2)nNRSO2(C1-6 aliphatic); n is zero or one; each R is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group; R2 is selected from hydrogen or, when R1 is â€”CO2(C1-3 aliphatic) or â€”CONH(C1-3 aliphatic), R2 is further selected from -halo, â€”CN, â€”C1-4 aliphatic, a three to five-membered heterocyclyl, or a five-membered heteroaryl; R3 is an optionally substituted piperidinyl or pyridyl ring; each R4 is indepependently selected from hydrogen, an optionally subtituted C1-6 aliphatic group, or two R4 taken together with the carbon to which they are attached form a three to six membered aliphatic ring; each R5 is independently selected from hydrogen, an optionally subtituted C1-4 aliphatic group, or two R5 taken together with the nitrogen to which they are attached form a five or six membered heterocyclic ring; and Ar is an optionally substituted piperidinyl or pyridyl ring.