Patent ID: 6518427
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound of the formula I wherein X1 and X2 are independently â€”H, â€”F, or â€”Cl;wherein Q1 is: wherein Z2 is â€”N(R8)â€”; wherein R1 is a) â€”CHO, b) â€”COCH3, c) â€”COCHCl2, d) â€”COCHF2, e) â€”CO2CH3, f) â€”SO2CH3, or g) â€”COCH2OH; wherein R2 is a) Hâ€”, b) CH3â€”, c) phenylâ€”CH2â€”, or d) CH3C(O)â€”; wherein R3 is a) (C1-C3)alkyl-, or b) phenyl-; wherein R4 is a) Hâ€”, b) (C1-C4)alkyl, c) aryl â€”(CH2)p, d) ClH2Câ€”, e) Cl2HCâ€”, f) FH2Câ€”, g) F2HCâ€”, or h) (C3-C6)cycloalkyl; wherein R7 is a) Hâ€”, or b) H3Câ€”; wherein R8 is a) R2Oâ€”C(R10)(R11)â€”C(O)â€”, b) R3Oâ€”C(O)â€”, c) R4â€”C(O)â€”, f) H3Câ€”C(O)â€”(CH2)2â€”C(O)â€”, g) R9â€”SO2â€”, i) R12â€”NHâ€”C(O)â€”; wherein R9 is a) â€”CH3, b) â€”CH2Cl c) â€”CH2CH&boxH;CH2, d) aryl, or e) â€”CH2CN; wherein R10 and R11 are independently a) Hâ€”, b) CH3â€”; or R10 and R11 taken together are â€”CH2â€”CH2â€”; wherein R12 is â€”(CH2)p-aryl; wherein m is zero (0) or one (1); wherein p is zero (0) or one (1); and wherein aryl is phenyl substituted with zero (0) or one (1) of the following: a) â€”F, b) â€”Cl, c) â€”OCH3, d) â€”OH, e) â€”NH2, f) â€”(C1-C4)alkyl, g) â€”Oâ€”C(O)â€”OCH3, h) â€”NO2, or i) â€”CN.