Patent ID: 9206133
Filing Date: 2015-12-08
Classification: A61P,C07D

Abstract:
1. A process for the preparation of crystalline polymorph type B of 7-chloro-4-(piperazin-1-yl)-quinoline, the process comprising: a) reacting 4,7-dichloroquinoline with anhydrous piperazine in a polar protic solvent for a time of between 6 and 10 hours at reflux temperature to give a suspension; b) filtrating the suspension obtained from a); c) removing the solvent under reduced pressure and washing the oil thus obtained until crystallization occurs; and d) washing the crystals obtained from c), to give the crystalline polymorph type B of 7-chloro-4-(piperazin-1-yl)-quinoline which has a X-ray powder diffraction pattern with at least five specific peaks at about 2-theta=6.95°, 20.40°, 25.80°, 10.30° and 13.70° wherein said values may be plus or minus 0.1° 2-theta and have an intensity of at least 30%, wherein the number of equivalents of anhydrous piperazine is less than 3 times the amount of 4,7-dichloroquinoline, and the crystalline polymorph type B of 7-chloro-4-(piperazin-1-yl)-quinoline has a purity equal to or higher than 99%.