Patent ID: 6768011
Filing Date: 2004-07-27
Classification: A61K,A61P,C07D

Abstract:
A method for the preparation of citalopram comprising reacting a compound of formula II with a compound of formula wherein R is halogen or â€”Oâ€”SO2â€”X wherein X is alkyl, alkenyl, alkynyl or optionally alkyl substituted aryl or aralkyl and R1 is dimethylamino, halogen, â€”Oâ€”SO2â€”X wherein X is as defined above, provided that R is not halogen when R1 is dimethylamino;and if R1 is dimethylamino followed by isolating citalopram base or a pharmaceutically acceptable acid addition salt thereof,and if R1 is halogen or â€”Oâ€”SO2â€”X wherein X is as defined above, followed by converting the resulting compound of formula wherein R2 is halogen or a group of formula â€”Oâ€”SO2â€”X wherein X is as defined above to citalopram, followed by isolating citalopram base or a pharmaceutically acceptable acid addition salt thereof.