Patent ID: 6258454
Filing Date: 2001-07-10
Classification: B05D,B32B,B82Y,G01N,Y10T

Abstract:
A substrate having a functionalized surface, comprising:a solid support having a plurality of surface hydrophilic, nucleophilic groups, a first fraction of which are covalently bound to an --Si--R.sup.1 moiety and a second fraction of which are covalently bound to an --Si--(L).sub.n --R.sup.2 moiety, wherein R.sup.1 is a chemically inert moiety that lowers the surface energy of the solid support and is selected from the group consisting of C.sub.10 to C.sub.18 alkyl and benzyl optionally substituted with 1 to 5 halogen atoms, n is 0 or 1, L is a linking group, R.sup.2 is a functional group enabling covalent binding of a molecular moiety or a modifiable group that can be converted to such a functional group, and the solid support is comprised of a material selected from the group consisting of polystyrene, agarose, dextran, cellulosic polymers, polyacrylamides, and glass.