Patent ID: 8772470
Filing Date: 2014-07-08
Classification: A61K,A61P,C12N

Abstract:
1. A pharmaceutical composition comprising a therapeutic agent effective to reduce the amount of active hsp27 in cancerous cells exposed to the therapeutic agent, and a pharmaceutically acceptable carrier, wherein the therapeutic agent comprises an RNAi molecule, wherein said RNAi molecule is from 18 to 23 nucleotides and comprises double-stranded or single-stranded RNA and mediates RNA inhibition by degradation of mRNA of the hsp27 gene and; wherein said RNAi molecule consists of a single-stranded sequence or two complementary sequences in a double stranded form that is/are the RNA counterpart of sequence of bases of the same length as the RNAi molecule within Seq ID No. 91 or complementary to Seq. ID No. 91, wherein the RNAi molecule has backbone modifications to provide resistance against nuclease digestion in vivo.