Patent ID: 7335767
Filing Date: 2008-02-26
Classification: C07D

Abstract:
1. A process for preparation of ceftiofur sodium of formula (Ib) having purity of more than 97% comprising the steps of: i) reacting cefotaxime or its salts or its esters of formula (VI)  wherein R ii) converting the ceftiofur of formula (Ia) to its salt with an organic amine by treating a solution of ceftiofur in a mixture of water and a water-miscible organic solvent with an organic amine, at a temperature ranging from −10° C. to 10° C.; iii) reacting the amine salt thus obtained with a sodium metal carrier in a mixture of water and water-miscible organic solvent and in presence of sodium hydrogen sulfite to give ceftiofur sodium of formula (Ib).