Patent ID: 9067923
Filing Date: 2015-06-30
Classification: A61K,A61P,C07D

Abstract:
1. A nitrogen-containing heterocyclic compound selected from the group consisting of: N,N-dimethyl-2-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)isonicotinamide (compound 1), N,N-dimethyl-2-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)nicotinamide (compound 2), N,N-dimethyl-6-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)picolinamide (compound 3), N-(3-(1-(1-(6-cyanopyridin-3-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 4), 5-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)picolinamide (compound 5), N-(3-(1-(1-(4-cyanopyridin-2-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 6), N-(3-(1-(1-(5-cyanopyridin-3-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 7), N,N-dimethyl-6-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)nicotinamide (compound 8), N-(3-(1-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 9), 2-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)nicotinamide (compound 10), N-(3-(2,2,2-trifluoro-1-(1-(2-methyl-2H-tetrazol-5-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 11), N-(3-(2,2,2-trifluoro-1-(1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 12), N-(3-(2,2,2-trifluoro-1-(1-(pyrazin-2-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 13), N-(3-(2,2,2-trifluoro-1-(1-(pyrimidin-5-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 14), N-(3-(1-(1-(5-cyanopyridin-2-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 15), N-(3-(1-(1-(2-cyanopyridin-4-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 16), N-(3-(1-(1-(3-cyanopyridin-4-yl)piperidin-4-yl)-2,2,2-trifluoroethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 17), N-(3-(2,2,2-trifluoro-1-(1-(thiazol-2-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 18), 6-(4-(2,2,2-trifluoro-1-(3-(propylsulfonamido)quinoxalin-2-yloxy)ethyl)piperidin-1-yl)nicotinamide (compound 19), N-(3-(2,2,2-trifluoro-1-(1-(pyridin-2-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 20), N-(3-(2,2,2-trifluoro-1-(1-(pyridin-3-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 21), and N-(3-(2,2,2-trifluoro-1-(1-(pyridin-4-yl)piperidin-4-yl)ethoxy)quinoxalin-2-yl)propane-1-sulfonamide (compound 22); or a pharmaceutically acceptable salt thereof.