Patent ID: 7063863
Filing Date: 2006-06-20
Classification: A61K,A61P,Y10S

Abstract:
1. A method of producing a system for delivering a drug or other biological agents, comprising the step of combining a reversible gelled matrix and the drug or other biological agents, wherein the reversible gelled matrix comprises a crosslinking agent and at least one receptor having a plurality of binding sites for a substrate in the environment of the matrix and for the crosslinking agent, the at least one receptor being activated in response to the levels of the substrate to effect a conformational change in the matrix allowing mobilisation and release of the drug or other biological agents into the environment, the conformational change in the matrix allowing mobilisation being effected by the binding of the substrate to the binding sites such that it displaces the crosslinking agent from the binding sites, and the conformational change in the matrix allowing immobilisation being effected by the binding of the crosslinking agent to the binding sites such that when the crosslinking agent becomes bound to the binding sites it displaces the substrate from the binding sites.