Patent ID: 7129087
Filing Date: 2006-10-31
Classification: A61K,A61P

Abstract:
1. A method for fusing a first cell with a member selected from the group consisting of a second cell, lipid bilayer vesicles and liposomes, comprising: (a) incorporating into the plasma bilayer membrane of said first cell an outwardly projecting first anchored oligonucleotide containing a first hydrophobic anchoring moiety attached to the 5′ or 3′ terminus of the first oligonucleotide, (b) incorporating into the bilayer membrane of said member an outwardly projecting second anchored nucleotide, complementary to said first anchored nucleotide, containing a second hydrophobic anchoring moiety attached to the 3′ or 5′ terminus of the second oligonucleotide, (c) mixing said first cell and said member under conditions promoting hybridization of said first and second outwardly projecting anchored oligonucleotides, and (d) incubating the mixture of said first cell and said member under conditions producing fusion thereof.