Patent ID: 8283432
Filing Date: 2012-10-09
Classification: A61K,A61P,C08G

Abstract:
1. A polymer formed by (a) reaction of a polyhydrosiloxane of general formula with a reactive compound to provide a functionalized polysiloxane, wherein the reactive compound comprises (1) a first reactive group, which is capable of reacting with an Si—H group, at one end, and (2) a second reactive group, which is capable of reacting with a fluoroquinolone antibiotic, at its other end; and (b) reaction of the functionalized polysiloxane with a fluoroquinolone antibiotic or a pharmaceutically acceptable salt thereof to provide a fluoroquinolone-functionalized polysiloxane; wherein R R x is 1 to 100; y is 0 to 100; z is 0 to 100; at least one of y and z is greater than 0; and the polymer contains at least one fluoroquinolone group.