Patent ID: 6335360
Filing Date: 2002-01-01
Classification: A61P,C07D

Abstract:
A compound of the following formula I: wherein:each R1 may be the same or different, and is selected from the group consisting of halogen, OH; C1-C6 alkyl optionally substituted by one or more radicals selected from the group consisting of halogen and OH; (C1-C6) alkenyl optionally substituted by one or more radicals selected from the group consisting of halogen and OH; (C1-C6) alkynyl, optionally substituted by one or more radicals selected from the group consisting of halogen and OH, X(C1-C6)alkyl, wherein X is S, 0 or OCO, and the alkyl is optionally substituted by one or more radicals selected from the group consisting of halogen and OH; SO2(C1-C6)alkyl, optionally substituted by at least one halogen, YSO3H, YSO2(C1-C6)alkyl, wherein Y is O or NH and the alkyl is optionally substituted by at least one halogen, a diradical â€”X1â€”(C1-C2)alkylene-X1â€” wherein X1 is O or S; and a benzene ring fused to the indoline ring; n is from 0 to 4; R2 is CH2R4, wherein R4 is C1-C6 alkyl substituted by one or more radicals selected from the group consisting of halogen and OH; (CH2)pZ(CH2)qCH3, wherein Z is O or S, p is from 0 to 5 and q is from 0 to 5, provided that p+q is from 0 to 5; (C2-C6) unsaturated alkyl; or (C3-C6) cycloalkyl; or R2 is (C1-C6)alkyl or O(C1-C6)alkyl, each optionally substituted by at least one halogen; R3 is H; (C1-C6)alkyl optionally substituted by at least one halogen; (CH2)pZR5 wherein p is from 1 to 3, Z is O or S and R5 is H or (C1-C3)alkyl; benzyl; or a pharmaceutically acceptable acid addition salt thereof; provided that: when R1 is a halogen atom; a Oâ€”(C1-C4)alkyl; OH or (C1-C4)alkyl group; R2 is CH2R4 wherein R4 is (CH2)2SCH3, â€”(CH2)2OH or cyclohexyl; or R2 is a (C1-C6)alkyl group; then R3 is neither a hydrogen atom nor a (C1-C4)alkyl group.