Patent ID: 9115133
Filing Date: 2015-08-25
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound of formula (Ia): wherein, Y 1 represents CR′ wherein R′ is H or alkyl; A is selected from R 1 is selected from hydrogen or alkyl; R 2 is selected from hydrogen or alkyl; R 3 is selected from hydrogen or alkyl; R 4 is selected from hydrogen, alkyl, alkoxy, cyano, halogen, hydroxy, hydroxyalkyl, haloalkyl, perhaloalkyl, carboxy, alkylcarboxy, carboxyalkyl, carboxyalkyloxy, alkylcarboxyalkyloxy or nitro; Z is a bond or is a group selected from cycloalkylene, arylene, heterocyclylene, heterocyclylenealkyl, heteroarylene, spirocyclyl, (C 1-6 )alkylene, (C 1-6 )alkenylene or (C 1-6 )alkynylene wherein one or more than one methylene groups from alkylene, alkenylene or alkynylene are optionally replaced by hetero atoms or groups selected from —O—, —S(O)p-, —N(R 5 )—, or —C(O); B is a bond or is a group selected from cycloalkylene, cycloalkenylene, arylene, heterocyclylene, heteroarylene, (C 1-6 )alkylene, (C 1-6 )alkenylene or (C 1-6 )alkynylene wherein one or more than one methylene groups from alkylene, alkenylene or alkynylene are optionally replaced by hetero atoms or groups selected from —O—, —S(O)p-, —N(R 5 )—, —C(O) or —C(═NR″)— wherein R″ is H, alkyl, cyano, hydroxy, hydroxyalkyl, haloalkyl or perhaloalkyl; D is selected from hydroxy, alkoxy, alkoxyalkyl, cyano, halogen, haloalkyl, perhaloalkyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyanoalkyl, acyl, cyanoalkylarbonyl, cyanoalkenylcarbonyl, —(CR a R b ) n OR 5 , —SR 5 , —(CR a R b ) n COOR 5 , —(CR a R b ) n NR 6 R 7 , —(CR a R b ) n C(O)NR 6 R 7 , —(CR a R b ) n NR 5 C(O)NR 6 R 7 , thiocarbonyl, S(O) 2 NR 6 R 7 , —NR 5 S(O) 2 R 5 , —S(O) p R 5 , —SO 3 H, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkyloxy, cycloalkylamino, aryl, arylalkyl, aryloxy, arylamino, heterocyclyl, heterocyclylalkyl, heterocyclyloxy, heterocycloalkylamino, heteroaryl, heteroarylalkyl, heteroaryloxy, or heteroarylamino; R 5 is selected from the group consisting of hydrogen, halogen, haloalkyl, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl and heterocyclylalkyl; wherein alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, or carboxyalkyl; R 6 and R 7 are independently selected from the group consisting of hydrogen, —(CR a R b ) n OR 5 , haloalkyl, —(CR a R b ) n C(O)R 5 , alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl, or R 6 and R 7 taken together form a monocyclic or a bicyclic ring system which is saturated or partially unsaturated and optionally have additional heteroatoms selected from O, N or S, the said ring system is further optionally substituted with 1 to 4 substituents independently selected from halo, alkyl, alkenyl, alkynyl, nitro, cyano, —(CR a R b ) n OR 5 , —SR 5 , oxo, alkylsulfonyl, —(CR a R b ) n COOR 5 , cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl; Z, B and D may be optionally substituted with one or more substituents independently selected from cyano, nitro, keto, oxo, halogen, haloalkyl, perhaloalkyl, hydroxyamino, —(CR a R b ) n OR 5 , —(CR a R b ) n C(O)R 5 OC(O)R 5 , —SR 5 , —(CR a R b ) n COOR 5 , —(CR a R b ) n NR 6 R 7 , —(CR a R b ) n C(O)NR 6 R 7 , —(CR a R b ) n NR 5 C(O)NR 6 R 7 , —NR 5 C(O)R 5 , thiocarbonyl, S(O) 2 NR 6 R 7 , —NR 5 , —S(O) 2 R 5 , —S(O) p R 5 , —SO 3 H, —OP(O)(R 8 ) q , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl; wherein alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, carboxyalkyl, —OC(O)R R 8 is selected from the group consisting of hydroxy and alkoxy; R a and R b are independently selected from the group consisting of hydrogen, —OR 5 , halogen, haloalkyl, perhaloalkyl and alkyl; n is 0-6; m is 0, 1 or 2; p is 0, 1 or 2; q is 1 or 2.