Patent ID: 6624170
Filing Date: 2003-09-23
Classification: A61K

Abstract:
A method of treating or retarding a malignant tumor in a mammal comprising administering subcutaneously to said mammal in need of such treatment an effective amount of a water-insoluble compound with a closed-lactone ring wherein said malignant tumor is selected from the group consisting of breast cancer, lung cancer, stomach cancer, ovarian cancer, pancreas cancer, prostate cancer, osteosarcoma, melanoma, and bladder cancer;and wherein said compound is selected from 20(S)-camptothecin, 9-nitro-20(S)-camptothecin, 7-ethyl-10-carbonyloxy-camptothecin (camptothecin-11), 7-ethyl-10-hydroxy-20(S)-camptothecin, 9-chloro-20(S)-camptothecin, 9-bromo-20(S)-camptothecin, 9-hydroxy-20(S)-camptothecin, 11-hydroxy-20(S)-camptothecin, 10-hydroxy-20(S)-camptothecin, or mixtures thereof.