Patent ID: 7195896
Filing Date: 2007-03-27
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A system comprising: (i) an adenoviral vector comprising an adenoviral genome having a deficiency in one or more essential gene functions of the E1 region of the adenoviral genome and a deficiency in one or more essential gene functions in either or both of the E2A region and the E4 region of the adenoviral genome, and optionally a deficiency in the E3 region of the adenoviral genome, and (ii) a cell having a cellular genome that complements in trans for the deficiency in one or more essential gene functions of the E1 region of the adenoviral genome and the deficiency in one or more essential gene functions in either or both of the E2A region and the E4 region, of the adenoviral genome, wherein and wherein there is no overlap between the cellular genome and the adenoviral genome that mediates a recombination event between the cellular genome and the adenoviral genome.