Patent ID: 6444840
Filing Date: 2002-09-03
Classification: C07C,C07D

Abstract:
A compound having the structure: characterized in that (a) R1 is CO2H, C(O)NHOH, CO2R7, CH2OH, S(O)2R7, C(O)NHR7, C(O)NHS(O)2R7, or tetrazole; characterized in that R7 is alkyl, heteroalkyl, monocyclic carbocyclic aliphatic ring, monocyclic heterocyclic aliphatic ring, monocyclic aromatic ring, or monocyclic heteroaromatic ring; (b) W is O, NH, S, S(O), S(O)2, or (CH2)m; characterized in that m is an integer from 0 to about 3; (c) R2 is H and R3 is H or lower alkyl, or R2 and R3 together form a covalent bond; (d) R4 is H, alkyl, heteroalkyl, monocyclic carbocyclic aliphatic ring, monocyclic heterocyclic aliphatic ring, monocyclic aromatic ring, or monocyclic heteroaromatic ring; (e) each R5 is independently selected from the group consisting of H, CH3, and C2H5; (f) X is NHR8 or OR8, characterized in that each R8 is independently selected from the group consisting of H, acyl, alkyl, heteroalkyl, monocyclic carbocyclic aliphatic ring, monocyclic heterocyclic aliphatic ring, monocyclic aromatic ring, and monocyclic heteroaromatic ring; (g) each R6 is independently selected from the group consisting of H, CH3, C2H5, OR8, and NHR8; (h) Y is O, NHR8, S, S(O), or S(O)2, provided no carbon has more than one heteroatom attached to it; (i) Z is H, methyl, monocyclic carbocyclic aliphatic ring, monocyclic heterocyclic aliphatic ring, monocyclic aromatic ring, monocyclic heteroaromatic ring, bicyclic carbocyclic aliphatic ring, bicyclic heterocyclic aliphatic ring, bicyclic aromatic ring, or bicyclic heteroaromatic ring, provided that when Y is S, S(O), or S(O)2 and Z is H, q is at least 1; (j) a and b are independently selected from the group consisting of single bond, cis double bond, and trans double bond; (k) p is an integer from 1 to 5, q is an integer from 0 to 5, and p+q is 1 to 5; and any optical isomer, diastereomer, enantiomer of the above structure or a pharmaceutically-acceptable salt, or bio-hydrolyzable amide, ester, or imide thereof.