Patent ID: 6441021
Filing Date: 2002-08-27
Classification: A61P,C07C,C07D

Abstract:
A composition for inhibiting metalloproteinase which comprises a compound of formula I: wherein R1 is optionally substituted heteroarylalkyl;R2 is hydrogen atom or optionally substituted lower alkyl; R3 is optionally substituted arylene; R4 is a bond, â€”(CH2)mâ€”, â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”; R5 is optionally substituted aryl; Y is â€”NHOH or â€”OH; and m is 1 or 2; provided R2 is hydrogen atom when Y is â€”NHOH, with the proviso that R5 and R3 together do not form a biphenyl group, and its optically active substance, pharmaceutically acceptable salt, or hydrate thereof.