Patent ID: 7368118
Filing Date: 2008-05-06
Classification: A61K,C07K,C12N

Abstract:
1. A method of stimulating a cytotoxic T cell response, said method comprising: a) providing an HBV immunogenic peptide of 6-35 amino acids in length wherein the amino acids of said peptide are identical to the amino acids of corresponding portions of at least one HBV amino acid sequence selected from the group consisting of HBenv 183-191 (Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile; SEQ ID NO: 1) and HBenv 335-343 (Trp-Leu-Ser-Leu-Leu-Val-Pro-Phe-Val; SEQ ID NO: 10); b) complexing the peptide or a fragment thereof, with an appropriate HLA molecule; and c) contacting an HLA-restricted CTL, which T cell recognizes a native HBV antigen, with the complex of the provided peptide and the HLA molecule, whereby a CTL response is stimulated.