Patent ID: 7125686
Filing Date: 2006-10-24
Classification: A61P,C07K

Abstract:
1. An osteoclastogenesis inhibitory factor protein comprising the following properties: (a) molecular weights as determined by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) of approximately 60 kD under reducing conditions, and approximately 60 kD (a monomer) and 120 kD (a homodimer) under non-reducing conditions; (b) high affinity to cation-exchange resins and heparin derivatives; (c) inhibitory activity for osteoclast differentiation and/or maturation, wherein said activity is decreased by heating said protein at about 70° C. for about 10 min. or at about 56° C. for about 30 min., and wherein said activity is lost by heating at about 90° C. for about 10 min.; and (d) an internal amino acid sequence as provided in Seq. ID Nos. 1, 2 or 3.