Patent ID: 6465456
Filing Date: 2002-10-15
Classification: C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein:L is oxygen or sulfur; L1 is selected from the group consisting of: R4â€”(CH2)mâ€”CR5(NR6R7)C(O)â€”, R8R9Nâ€”(CH2)nâ€”C(O)â€”, C1-6alkylC(O)CH2C(O)â€”, R10â€”Xâ€”CH2C(O)â€”, R10â€”CH&boxH;CHâ€”C(O)â€”, R10â€”NHC(O)CH2â€”, R10â€”(CH2)pâ€” and R10â€”S(O)2â€”; m is 0 or an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 2 to 6; X is selected from the group consisting of: a bond, sulfur, oxygen, NH and N(C1-4alkyl); R1 is selected from the group consisting of: hydrogen, C1-8alkyl, C3-6cycloalkyl and C1-8alkoxy, said C1-8alkyl optionally substituted with one or more fluoro, chloro, hydroxy, C1-8alkoxy or C1-8acyloxy; R2 and R3 are each independently selected from the group consisting of: hydrogen, halogen, hydroxy, nitro, amino, cyano, C1-6alkyl, C1-6alkoxy and trifluoromethyl; R4 is selected from the group consisting of: hydrogen, hydroxy, C1-6thioalkoxy, imidazolyl, indolyl, â€”CO2H and â€”NHC(&boxH;NH)NH2; R5 is hydrogen or C1-6alkyl; or R4 and R5 taken together can be â€”CH2â€” when m is 1; R6 and R7 are each independently selected from hydrogen or C1-6alkyl; or R4 and R6 taken together can be â€”(CH2)qâ€” when m is 1 and wherein q is 2 or 3; R8 and R9 are each independently selected from hydrogen or C1-6alkyl; or R8 and R9 taken together with the nitrogen to which they are attached are morpholin-4-yl, piperazin-1-yl, piperidin-1-yl or â€”NHC(&boxH;NH)NH2; R10 is heteroaryl, said heteroaryl selected from the group consisting of imidazolyl, benzoimidazolyl, thienyl, benzothienyl, furanyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyrolyl, thiadiazolyl, oxadiazolyl, triazolyl, triazinyl and tetrazolyl, and said heteroaryl optionally substituted with one to three same or different amino, hydroxy, halogen, C1-6alkyl, morpholin-4-yl, piperazin-1-yl, piperidin-1-yl, phenyl, â€”CO2H or â€”CO2C1-6alkyl; and provided R4 is hydrogen or C1-6alkyl and R5 is C1-6alkyl when m is 0.