Patent ID: 6066641
Filing Date: 2000-05-23
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR6## wherein: Q.sub.3 is selected from the group consisting of a bond, C.sub.1-8 alkylene, C.sub.2-8 alkenylene and C.sub.2-8 alkynylene;Q.sub.8 is selected from the group consisting of C.sub.1-8 alkylene, C.sub.2-8 alkenylene and C.sub.2-8 alkynylene;R.sub.3 is selected from the group consisting of hydrogen, aryl, pyridyl, pyrimidyl, quinolyl and isoquinolyl, wherein said aryl, pyridyl, pyrimidyl, quinolyl and isoquinolyl are optionally substituted by halogen, hydroxy, alkoxy, nitro, cyano and carboxy;R.sub.8 is selected from the group consisting of hydrogen, aryl, pyrimidyl, quinolyl and isoquinolyl, wherein said aryl, pyrimidyl, quinolyl and isoquinolyl are optionally substituted by halogen, hydroxy, alkoxy, nitro, cyano and carboxy;provided that Q.sub.3 R.sub.3 is not hydrogen or methyl; and at least one of R.sub.3 and R.sub.8 is aryl, pyridyl, pyrimidyl, quinolyl or isoquinolyl; andwhen Q.sub.3 R.sub.3 or Q.sub.8 R.sub.8 are a C.sub.1-8 alkyl, said C.sub.1-8 alkyl is optionally substituted with one or more halogens, hydroxy, alkoxy or cycloalkyl groups.