Patent ID: 7399761
Filing Date: 2008-07-15
Classification: A61P,C07D

Abstract:
1. A compound of the formula I, wherein r is 1 or 2, n is 0-3, t is 0, 1 or 2, R1 and R2 together form a bridge of subformula I*, wherein the bond is achieved via the two terminal C atoms and wherein said ring formed by the bridge is a benzo ring and m is 0 to 4, G is —CH A, B, D, E and T are independently N or CH subject to the proviso that only one of these radicals is N; Q is either lower alkoxy or O (oxo), with the proviso that if Q is lower akoxy, the waved line representing the bonding of Q is a single bond and the ring carrying Q has three double bonds, and if Q is O, the waved line representing the bonding of Q is a double bond and for each Q =O, one of the double bonds in the ring is changed to a single bond; and with the proviso that any Q is bonded to a ring C atom; Q′ is halogen, NHR R X is imino, oxa, or thia; Y is hydrogen, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or unsubstituted or substituted cycloalkyl; and Z is independently mono- or disubstituted amino, halogen, alkyl, cycloalkyl, substituted alkyl, hydroxy, etherified or estherified hydroxy, nitro, cyano, carboxy, esterified carboxy, —OCOR with the proviso that when two groups R and with the proviso that only compounds other than those wherein r is 1, n is 0, R or an N-oxide of a compound of formula I, wherein 1 or more N atoms carry an oxygen atom; or a tautomer or mixture of tautomers of a compound of formula I or an N-oxide thereof; or a pharmaceutically acceptable salt of a compound of formula I, of an N-oxide or of a tautomer or mixture of tautomers thereof.