Patent ID: 6406912
Filing Date: 2002-06-18
Classification: C07D,C12P,Y10S

Abstract:
A process for the kinetic resolution of racemates of a compound of the formula (I), which comprises subjecting enantiomer mixtures or racemic mixtures of the compound of the formula (I), in whichR is COR1 where R1=(C1-C16)-alkyl, (C2-C16)-alkenyl or (C3-C16)-alkynyl, CnH2n-cycloalkyl where n=1-16, which can be branched or unbranched and which can be substituted by 1-3 substituents from the group F, Cl, Br, I, CF3, CN, NO2, hydroxyl, methoxy, ethoxy and COOR2, where R2=(C1-C4)-alkyl or (C2-C4)-alkenyl, which can be branched or unbranched and which can be substituted by 1-3 substituents from the group consisting of F, Cl, Br, and CF3, in homogeneous or heterogeneous, aqueous, aqueous/organic or organic media in the presence of an enzyme, to a stereoselective hydrolysis or alcoholysis at a temperature of 10-80Â° C., optionally in the presence of one or more cosolvents and of a buffer and, after the reaction has taken place, separating the unreacted ester and the alcohol formed.