Patent ID: 8263746
Filing Date: 2012-09-11
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. An isolated human antibody that specifically binds an epitope of CD38 (SEQ ID NO: 22), wherein said antibody mediates killing of a CD38+ target cell by antibody dependent cellular cytotoxicity with at least five-fold better efficacy than chimeric OKT10 antibody (SEQ ID NOS: 23 and 24) under the same or substantially the same conditions when a human PBMC cell is employed as the effector cell, wherein said CD38+ target cell is selected from the group consisting of LP-1 (DSMZ: ACC41) and RPMI-8226 (ATCC: CCL-155), and wherein the ratio of effector cells to target cells is between about 30:1 and about 50:1.