Patent ID: 6503908
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound of formula I, whereinR1 and R2 independently represent phenyl (optionally substituted by one or more substituents selected from halo, â€”CN, â€”CF3, â€”OCF3, C1-4 alkoxy or C1-4 alkyl (which latter two groups are optionally substituted by C1-4 haloalkyl or C1-4 haloalkoxy)) or C1-6 alkyl optionally interrupted by â€”Oâ€”, â€”Sâ€” and/or â€”N(R4)â€” and/or optionally substituted and/or terminated by Het2, a N-linked heterocyclic group (selected from piperidinyl and morpholinyl) or phenyl (which latter group is optionally substituted by one or more substituents selected from halo, â€”CN, â€”CF3, â€”OCF3, C1-4 alkoxy or C1-4 alkyl (which latter two groups are optionally substituted by C1-4 haloalkyl or C1-4 haloalkoxy)); R4 represents H or C1-4 alkyl; R3 represents OR5 or N(R6)R7; R5 represents C3-6 cycloalkyl, â€”(C1-4 alkylene)-1-piperidinyl, tetrahydrofuranyl, tetrahydropyranyl or C1-6 alkyl, which latter group is optionally substituted and/or terminated by one or two substituents selected from C3-5 cycloalkyl, â€”OR8, â€”N(R6)R7, phenyl, furanyl and pyridinyl, and which C1-6 alkyl group is optionally terminated by a C1-4 haloalkyl group; R6 and R7 independently represent, at each occurrence, H, C1-4 alkyl (optionally substituted by C3-5 cycloalkyl or C1-4 alkoxy), or R6 and R7, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholinyl group; R8 represents H, C1-4 alkyl (which C1-4 alkyl group is optionally terminated by a C1-4 haloalkyl group) or benzyl; Het1 represents a 4-R9-1-piperazinyl group optionally substituted with one or two C1-4 alkyl groups and optionally in the form of its 4-N-oxide; R9 represents H, pyridinyl, pyrimidinyl, C3-6 alkenyl or C1-4 alkyl optionally substituted by one or two substituents selected from â€”OH, â€”N(R6)R7, â€”C(O)N(R6)R7, benzodioxolyl, benzodioxanyl or phenyl (which latter group is optionally substituted by C1-4 alkoxy); Het2 represents a C-linked 6-membered heterocyclic group containing one or two nitrogen atoms, optionally in the form of its mono-N-oxide, or a C-linked 5-membered heterocyclic group containing two or three nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1-4 alkyl, C1-4 alkoxy or N(H)R10; and R10 represents H, C1-4 alkyl or C1-4 alkanoyl; or a pharmaceutically, or a veterinarily, acceptable derivative thereof.