Patent ID: 6090842
Filing Date: 2000-07-18
Classification: A61P,C07D

Abstract:
A method of making a compound having the formula III: ##STR17## wherein W.sub.1, W.sub.2 (i) jointly denote --S--S--, --S(O)--S-- or --S--S(O)--, or (ii) individually denote a group comprising an oxidized sulfur atom;L.sub.3 denotes (i) a single bond, (ii) a methylene group or a C.sub.6-10 arylene group which is unsubstituted or substituted with a halogen, hydroxyl, amine or unbranched or branched C.sub.3-16 alkyl, alkenyl, or alkynyl group or (ii) a linking group having a carbon backbone comprising 2 to 16 carbon atoms, wherein a carbon atom in said carbon backbone can be replaced by an oxygen atom, an unsubstituted or substituted amine group, a sulfur atom, an unsubstituted or substituted C.sub.6-10 aryl group or a combination thereof;Y denotes a urethane or unsubstituted or alkyl-substituted amide linkage;n denotes 0 or 1; andZ denotes a group containing a nitrogen atom that is in equilibrium with a protonated form thereof,said method comprising the step of reacting a compound having the formula VI ##STR18## with a compound having the formula VIIIY.sub.4 VIIIto form a product,whereinY.sub.3 denotes Y.sub.1 or a group that reacts with Y.sub.4 to form an imine group of a guanidine group;Y.sub.4 denotes Y.sub.2 --Z or a reagent that reacts with Y.sub.3 to form an imine group or a guanidine group; andY.sub.1 and Y.sub.2 denote groups which react to form an ester, thioester, urethane, or unsubstituted or substituted amide linkage.