Patent ID: 7754437
Filing Date: 2010-07-13
Classification: A61P,C12Q,G01N

Abstract:
1. A method for qualitatively and quantitatively detecting an extent of use of mammalian aerobic glucose fermentation metabolic pathway (mam-aGF) and a normal process flow of said pathway in a mammalian individual, wherein transketolase-like 1 (TKTL1) protein is used as indicator and target molecule or a TKTL1 nucleic acid or a fragment thereof is used as a target molecule or indicator, said method comprising: taking a biological sample of said individual, determining an activity and/or concentration, and/or cellular localization and/or aggregation status and/or dimerization status of the TKTL1 protein or the TKTL1 nucleic acid within said sample of said individual and within a control sample, comparing determined data obtained from said sample of said individual with data obtained from the control sample, wherein (i) an enhanced or decreased level of activity and/or concentration of the TKTL1 protein or of the TKTL1 nucleic acid in said sample of the individual compared to the control sample provides an indication of an enhancement or decrease in said extent of use of mammalian aerobic glucose fermentation metabolic pathway, and (ii) an abnormal cellular localization and/or an abnormal aggregation status and/or an altered dimerization of the TKTL1 protein in said sample of the individual compared to the control sample provides an indication of an abnormal process flow of said mammalian aerobic glucose fermentation metabolic pathway.