Patent ID: 6759390
Filing Date: 2004-07-06
Classification: C07H

Abstract:
A compound represented by the general formula:X-&agr;1,6-D-myo-inositol wherein:X represents a sugar residue; the sugar residue is substituted with one or more negatively charged groups; the sugar residue is optionally further substituted with between one and three groups, and the myo-inositol is unsubstituted or is substituted with between one and five groups, the group or groups being independently selected from: (a) the phosphoryl groups phosphate â€”Oâ€”P(O)(OH)2; thiophosphate â€”Oâ€”P(S)(OH)2; phosphate esters â€”Oâ€”P(O)(OR)2; thiophosphate esters â€”Oâ€”P(S)(OR)2; phosphonate â€”Oâ€”P(O)OHR; thiophosphonate â€”Oâ€”P(S)OHR; substituted phosphonate â€”Oâ€”P(O)OR1R2; substituted thiophosphonate â€”Oâ€”P(S)OR1R2; â€”Oâ€”P(S)(OH)(SH); cyclic phosphate; (b) the phosphorus containing compounds phosphoramidite â€”Oâ€”P(OR)â€”NR1R2 and phosphoramidate â€”Oâ€”P(O)(OR)â€”NR1R2; (c) the sulphur-containing groups â€”Oâ€”S(O)(OH), â€”SH, â€”SR, â€”S(â€”O)â€”R, â€”S(O)2R, ROâ€”S(O)2âˆ’, â€”Oâ€”SO2NH2, â€”Oâ€”SO2R1R2 or sulphamide â€”NHSO2NH2; (d) the amino groups â€”NHR, â€”NR1R2, â€”NHAc, â€”NHCOR, â€”NHâ€”Oâ€”COR, â€”NHSO3âˆ’, â€”NHSO2R, â€”N(SO2R)2, the amidino group â€”NHâ€”C(&boxH;NH)NH2 and the ureido group â€”NHâ€”COâ€”NR1R2 or thiouriedo group â€”NHâ€”C(S)â€”NH2; (e) the hydroxy group; the substituted hydroxy groups â€”OR3, where R3 is C1-10 unsubstituted or substituted alkyl, alkoxyalkyl, aryloxyalkyl, cycloalkyl, alkenyl (unsubstituted alkyl), alkylene (C3-7 cycloalkyl), â€”OCOR, aryl, heteroaryl, acetal, or said substituted groups comprise two hydroxyl groups joined to form a ketal; (f) the halogen substituents fluorine or chlorine; and (g) hydrogen, forming a deoxy sugar; wherein R, R1 and R2 are independently hydrogen or C1-10 unsubstituted or substituted alkyl or aryl; or a derivative thereof.