Patent ID: 6723706
Filing Date: 2004-04-20
Classification: A61K,A61P,C07H,C12N

Abstract:
A modified oligodeoxynucleotide comprising SEQ ID NO:1, wherein the modified oligodeoxynucleotide is characterized in that SEQ ID NO:1 has one of the following nucleotide linkage variations;(a) 5â€²-TsAsToToCsCoGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (b) 5â€²-TsAsToToCsCoGsToCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (c) 5â€²-TsAoTsToCsCoGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (d) 5â€²-TsAoTsTsCsCoGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (e) 5â€²-TsAoTsToCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (f) 5â€²-TsAoTsTsCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (g) 5â€²-TsAsToToCsCsGsToCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (h) 5â€²-TsAoTsTsCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (i) 5â€²-TsAsTsTsCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (j) 5â€²-TsAsToToCoCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (k) 5â€²-TsAsTsToCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (l) 5â€²-TsAsTsToCsCoGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (m) 5â€²-TsAsToTsCsCoGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (n) 5â€²-TsAsToToCsCsGoTsCoAsT-3â€²Oâ€”PO2â€”Oâ€”R, (o) 5â€²-TsAsToTsCsCoGoTsCoAsT-3â€²Oâ€”PO2â€”Oâ€”R, (p) 5â€²-TsAoTsTsCoCsGoTsCoAsT-3â€²Oâ€”PO2â€”Oâ€”R, (q) 5â€²-TsAsTsToCsCsGoToCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (r) 5â€²-TsAsTsToCoCsGoToCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (s) 5â€²-ToAoTsToCsCoGoToCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, (t) 5â€²-TsAsTsTsCsCsGoTsCsAsT-3â€²Oâ€”PO2â€”Oâ€”R, wherein:o means a phosphodiester internucleoside linkage, s means a phosphorothioate internucleoside linkage, R means a C8-C21 alkyl group, â€”(CH2â€”CH2O)nâ€”(CH2)mâ€”CH3 or â€”CH2CH(OH)CH2O(CH2)qâ€”CH3, wherein n is an integer from 1 to 6, m is an integer from 0 to 20 and q is an integer from 7 to 20 and A is 2â€²-deoxyadenosine, G is 2â€²-deoxyguanosine, C is 2â€²-deoxycytidine and T is thymidine.