Patent ID: 6103903
Filing Date: 2000-08-15
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR24## or a pharmaceutically acceptable non-toxic salt thereof wherein: the C ring represents a thiophene, or a pyridine ring each of which is optionally substituted with one or two groups independently selected from a group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, hydroxy, amino, mono- or di-(C.sub.1 -C.sub.6)alkylamino, and trifluoromethyl;W is aryl, or heteroaryl; each of which is optionally mono or disubstituted independently with halogen, hydroxy, lower alkyl, lower alkoxy, amino, or mono- or dialkylamino where each alkyl portion is lower alkyl, or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are the same or different and represent lower alkyl; and R represents hydrogen, (C.sub.1 -C.sub.6) alkyl, hydroxy (C.sub.1 -C.sub.6) alkyl, amino(C.sub.1 -C.sub.6)alkyl, mono- or di(C.sub.1 -C.sub.6)alkyl, amino(C.sub.1 -C.sub.6) alkyl, alkoxy(C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6)alkoxy, aryl(C.sub.1 -C.sub.6)alkyl; orCONR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen or lower alkyl.