Patent ID: 6350458
Filing Date: 2002-02-26
Classification: A61K

Abstract:
A pharmaceutical composition comprising:an effective amount of a macromolecular pharmaceutical agent; an alkali metal alkyl sulfate; at least one alkali metal salicylate; a pharmaceutically acceptable edetate; at least one micelle-forming compound selected from the group consisting of lecithin, hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, borage oil, evening of primrose oil, menthol, trihydroxy oxocholanyl glycine, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers, polidocanol alkyl ethers, chenodeoxycholate, deoxycholate, pharmaceutically acceptable salts thereof, analogs thereof, and mixtures or combinations thereof; and a suitable solvent; wherein the alkali metal alkyl sulfate, the alkali metal salicylate, the edetate and the micelle-forming compound are each present in a concentration of between about 1 and 20 wt./wt. % of the total composition, and the total concentration of the alkali metal alkyl sulfate, the alkali metal salicylate, the edetate and micelle-forming compound together is less than 50 wt./wt. % of the composition; and wherein the macromolecular pharmaceutical agent is in micellar form.