Patent ID: 6377828
Filing Date: 2002-04-23
Classification: A61B,G01N

Abstract:
A method of measuring an analyte in a tissue of a subject comprising:(a) contacting the tissue with electromagnetic radiation having a first excitation wavelength, wherein the first excitation wavelength is sufficiently absorbed by a temperature probe within the tissue so as to increase the temperature of the temperature probe, and wherein the temperature probe and the analyte are sufficiently proximate to one another that energy deposited into one by absorption of radiation is transferred to the other so as to enhance anti-Stokes spectra scattered by the analyte; (b) collecting the Raman spectra emitted by the tissue, wherein the Raman spectra comprise anti-Stokes spectra associated with the analyte; and (c) analyzing the collected spectra to determine a concentration of the analyte present in the tissue.