Patent ID: 6596903
Filing Date: 2003-07-22
Classification: C07C,C07D

Abstract:
A method for producing an amide derivative of the formula [XV]wherein R4 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl or an optionally substituted heteroarylalkyl, R6 and R7 are the same or different and each is a hydrogen atom, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl or an optionally substituted aralkyl, or R6 and R7 combinedly form, together with the adjacent nitrogen atom, a hetero ring, said hetero ring being optionally substituted by halogen atom, alkyl, alkenyl, alkoxy, amino, alkoxycarbonyl, carboxamide or alkyl-substituted carbamoyl, and R8 is a hydrogen atom, an alkyl, an optionally substituted aryl or an optionally substituted aralkyl, or an enantiomer thereof, comprising subjecting a 4-(2-amino-1-hydroxyethyl)oxazoline derivative of the formula [XIII]wherein R4, R6 and R7 are as defined above, or an enantiomer thereof to ring opening with a mercaptane of the formula [XIV]R8â€”SHâ€ƒâ€ƒ[XIV]wherein R8 is as defined above.