Patent ID: 6380250
Filing Date: 2002-04-30
Classification: A61K,A61P,C07B,C07C

Abstract:
A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound represented by formula I: wherein a wavy segments indicate either the alpha (&agr;) or beta (&bgr;) configuration; the dashed bond represents a double bond or a single bond; Ar is a heteroaryl radical selected from the group consisting of thienyl and furyl radicals and substituted derivatives thereof; n is 0 or an integer of from 1 to 4; x is 1 and y is 0; R1 is hydrogen or a lower alkyl radical or a substituted lower alkyl radical having up to six carbon atoms wherein the substituent on the lower alkyl or heteroaryl radical is selected from the group consisting of lower alkyl, hydroxy, lower alkyloxy, halogen, trifluoromethyl (CF3), COR1, COCF3, SO2NR1, SO2NH2, NO2 and CN.; X is selected from the group consisting of â€”OR1 and â€”N(R1)2; Y is &boxH;O or represents 2 hydrogen radicals, and the 9 and/or 11 esters thereof and/or the pharmaceutically acceptable salts of said compounds and/or esters.