Patent ID: 6262024
Filing Date: 2001-07-17
Classification: A61K,A61P,C07K

Abstract:
A purified, secretable, acidic neuron regulatory factor (NRF) complex isolated from rat neonatal cerebral cortex, or from human retinoblastoma cells, wherein said NRF complex does not comprise NGF, CNTF, bFGF, or aFGF, yet consists of a complex of polypeptides exhibiting an apparent molecular weight of between about 200 kDa and 220 kDa as determined by SDS-polyacrylamide gel electrophoresis under non-reducing conditions, wherein said NRF complex increases survival of cultured embryonic posterolateral thalamic neurons, hippocampal neurons and dorsal lateral geniculate nucleus neurons, and wherein said NRF complex activity is inhibited by 5 mM glycine.