Patent ID: 7794742
Filing Date: 2010-09-14
Classification: A61K,A61L

Abstract:
1. A partially implantable medical device, comprising at least one epithelial tissue contacting surface, wherein the epithelial tissue contacting surface comprises a layer of a biomaterial, wherein the biomaterial comprises a plurality of immobilized Notch ligand molecules, wherein each immobilized Notch ligand: (i) comprises the human Delta, Serrate, Lag-s (“DSL”) sequence set forth as SEQ ID NO:4; (ii) binds to a Notch receptor; and (iii) promotes differentiation of one or more epithelial cells in the contacted epithelial tissue, wherein the carboxyl-terminal end of each of the plurality of Notch ligand molecules is immobilized to the biocompatible epithelial tissue contacting surface of the biomaterial.