Patent ID: 6610518
Filing Date: 2003-08-26
Classification: C07D

Abstract:
A process for making compounds of formula (I)Râ€”NHSO2â€”Xâ€”Yâ€”Zâ€ƒâ€ƒ(I) whereinR is an organic radical; X is selected from a) 5-6 membered monocyclic aromatic ring optionally containing one or two heteroatoms, each independently selected from O, N and S; b) a C1-C6 alkylene group, straight or branched; and c) a direct link; Y is â€”C(CH3)2â€” or â€”CH(CH3)â€”; and Z is â€”CH2OH or â€”COOH; which comprises oxidising a compound of formula (II)Râ€”NHSO2â€”Xâ€”Yâ€”CH3â€ƒâ€ƒ(II) with a cytochrome P450 enzyme.