Patent ID: 8609373
Filing Date: 2013-12-17
Classification: C07K

Abstract:
1. A mixture comprising fusion proteins, wherein each of the fusion proteins comprises the structure: PTD-NES-SUMO-Specific Protein, in that specific order; wherein the PTD is a Protein Transduction Domain, and wherein the PTD is the TAT PTD region of HIV TAT; wherein the NES is a Nuclear Export Sequence, and wherein the NES is human IkBa Nuclear Export Sequence; wherein the SUMO is small ubiquitin-like modifier, wherein the SUMO is yeast SMT3p; wherein the Specific Protein is any one of the proteins selected from the group consisting of C-myc, SOX2, KLF4 or OCT-4; wherein the PTD-NES-SUMO moiety of the fusion protein is encoded by a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1; and wherein an applied concentration of each of the fusion proteins in the mixture is 1 ng/ml-1 mg/ml.