Patent ID: 6764998
Filing Date: 2004-07-20
Classification: A61P,C07H

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt, ester, or prodrug thereof: wherein:W is (a) â€”CH2â€”C(A)&boxH;C(B)â€”CH2â€”, wherein, A and B are independently selected from: 1. hydrogen; 2. deuterium; 3. halogen; 4. R1, wherein R1 is selected from: a. â€”C1-C6 alkyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; b. â€”C2-C6 alkenyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; or c. â€”C2-C6 alkynyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; 5. R2, wherein R2 is selected from: a. aryl; b. heteroaryl; c. substituted aryl; d. substituted heteroaryl; e. heterocycloalkyl; or f. substituted heterocycloalkyl; 6. â€”(C1-C3-alkyl)-Mâ€”(C1-C3-alkyl)-R2, wherein M is selected from â€”Oâ€”, â€”NHâ€”, â€”N(CH3)â€”, â€”NHC(O)â€” or â€”S(O)nâ€”, wherein n=0, 1 or 2, and R2 is as previously defined: 7. â€”(C1-C3-alkyl)-Mâ€”R2, wherein M and R2 are as previously defined; 8. â€”C(O)â€”Vâ€”R3, wherein V is absent, O or S, and R3 is H, R1 or R2; where R1 and R2 are as previously defined; or 9. â€”(O)â€”NR11R12, wherein R11 and R12 are each independently selected from: a. hydrogen; b. â€”C1-C6-alkyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; c. â€”C2-C6-alkenyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; d. â€”C2-C6-alkynyl, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; or â€ƒin the alternative, R11 and R12taken together with the nitrogen atom to which they are connected form a 3-to 7-membered ring which may optionally contain one or more double bonds and one or more heterofunctions selected from â€”Oâ€”, â€”NHâ€”, â€”N(C1-C6-alkyl)-, â€”N(R2)â€”, â€”S(O)nâ€”, wherein n and R2 are as previously defined; (b) â€”CH2â€”CH(A)â€”C(B)&boxH;CHâ€”, wherein A and B are as previously defined; (c) â€”CH2â€”CH(E)â€”CH(G)â€”CH2â€”, wherein E and G are independently selected from 1. A, wherein A is as previously defined; 2. â€”OH; 3. â€”ORp, wherein Rp is a hydroxy protecting group; 4. â€”Oâ€”R9, wherein R9 is R1 or R2, and wherein R1 and R2 are as previously defined; 5. â€”S(O)nR9, wherein n and R9 are as previously defined; 6. â€”NHC(O)R3, wherein R3 is as previously defined; 7. â€”NHC(O)NR11R3, wherein R11 and R3 are as previously defined; 8. â€”NHS(O)2R9, wherein R9 is as previously defined; 9. â€”NHR13, wherein R13 is an amino protecting group; or 10. â€”NR11R12, wherein R11, and R12 are as previously defined; (d) â€ƒwherein â€”Jâ€” is selected from â€”Oâ€”; â€”Oâ€”C(O)â€”CH(R7)â€”; â€”N(R7)â€”; â€”Oâ€”C(O)â€”N(R7)â€”; â€”Oâ€”C(O)â€”Oâ€”; â€”N(R7)â€”N&boxH;Nâ€”; â€”C(R7)&boxH;Nâ€”Oâ€”; or â€”CH(R7)â€”N(R8â€”Oâ€”; wherein R7 and R8 are independently selected from R3, wherein R3 is as previously defined; or, in the alternative, â€”Jâ€” is taken with the two carbon atoms to which it is attached to form a cyclic moiety selected from a. C3-C12 cycloalkyl; b. C3-C12 cycloalkenyl; or c. heterocycloalkyl; or (e) â€”CH2â€”C(R4)(R5)â€”CH2â€”CH2â€”, wherein R4 and R5 taken together with the carbon atom to which they are attached are selected from: 1. C&boxH;O; 2. C(OR1)2, wherein R1 is as previously defined; 3. C(SR1)2, wherein R1 is as previously defined; 4. C(OR12)(OR13), where R12 and R13 taken together are â€”(CH2)mâ€”, and where m is 2 or 3; 5. C(SR12)(SR13), where R12 and R13 taken together are â€”(CH2)mâ€”, where m is as previously defined; 6. C&boxH;CHR3, wherein R3 is as previously defined; 7. C&boxH;Nâ€”Oâ€”R3, wherein R3 is as previously defined; 8. C&boxH;NNHR3, wherein R3 is as previously defined; 9. C&boxH;NNHC(O)R3, wherein R3 is as previously defined; 10. C&boxH;NNNHC(O)NR11R3, wherein R11 and R3 are as previously defined; 11. C&boxH;NNHS(O)2R9, wherein R9 is as previously defined; 12. C&boxH;NNHR13, wherein R13 is as previously defined; or 13. C&boxH;NR9, wherein R9 is as previously defined; L is (a) â€”CH3; (b) â€”CH2CH3; (c) â€”CH(OH)CH3; (d) â€”C1-C6-alkyl, optionally substituted with one or more substituents selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (e) â€”C2-C6 alkenyl, optionally substituted with one or more substituents selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; or (f) â€”C2-C6alkynyl, optionally substituted with one or more substituents selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; D is â€”N(Q)CH2â€”, N(Râ€²)C(O)â€”, or â€”N&boxH;C(ORâ€²)â€”, wherein Râ€² is R11 as previously defined; Q is (a) hydrogen; (b) â€”C1-C12-alkyl, C2-C12-alkenyl, or C2-C12-alkynyl, all optionally substituted with one, two or three substituents independently selected from: 1. halogen; 2. â€”OR6, wherein R6 is selected from: a. hydrogen; b. â€”C1-C12-alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S or N, optionally substituted with one, two, or three substituents independently selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; c. aryl; d. substituted aryl; e. heteroaryl; f. substituted heteroaryl; g. heterocycloalkyl; or h. substituted heterocycloalkyl; 3. â€”NR4R5, where R4 and R5 are each independently R6, where R6 is as previously defined, or in the alternative R4 and R5, together with the atom to which they are attached, form a heterocycloalkyl or substituted heterocycloalkyl moiety; 4. &boxH;Nâ€”Oâ€”R6, where R6 is as previously defined; 5. â€”R1, where R1 is as previously defined; 6. â€”C3-C8-cycloalkyl; 7. substituted â€”C3-C8-cycloalkyl; 8. heterocycloalkyl; 9. substituted heterocycloalkyl; 10. â€”NHC(O)R6, where R6 is as previously defined; 11. â€”NHC(O)OR7, where R7 is selected from: a. â€”C1-C12-alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S or N, optionally substituted with one, two, or three substituents independently selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; b. aryl; c. substituted aryl; d. heteroaryl; e. substituted heteroaryl; f. heterocycloalkyl; or g. substituted heterocycloalkyl; 12. â€”NHC(O)NR4R5, where R4 and R5 are as previously defined; 13. â€”OC(O)NR4R5, where R4 and R5 are as previously defined; 14. â€”OC(O)R7, where R7 is as previously defined; 15. â€”OC(O)OR7, where R7 is as previously defined; 16. â€”OC(O)NR4R5, where R4 and R5 are as previously defined, 17. â€”C(O)R6, where R6 is as previously defined, 18. â€”CO2R6, where R6 is as previously defined, or 19. â€”C(O)NR4R5, where R4 and R5 are as previously defined; X is hydrogen; Y is (a) hydrogen; (b) â€”OH; (c) â€”ORp, where Rp is as previously defined; (d) â€”ORy, where Ry is R1 and R2 as previously defined; (e) â€”OC(O)Ry, where Ry is R1 and R2 as previously defined; (f) â€”OC(O)NHRy, where Ry is R1 and R2 as previously defined; (g) â€”S(O)nRy, where n is previously defined and Ry is R1 and R2 as previously defined; (h) â€”â€ƒwhere R3â€³ is hydrogen or methyl; R4â€³ is hydrogen or Rp, where Rp is as previously defined; or (i) in the alternative, X and Y combined together are oxo; Z is (a) hydrogen; (b) methyl; or (c) halogen; and R2â€² is hydrogen or Rp, where Rp, is as previously defined.