Patent ID: 7666419
Filing Date: 2010-02-23
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a subject afflicted with HIV-1 which comprises administering to the subject an effective HIV-1 treating dosage amount of (1) an anti-CCR5 antibody comprising (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising the expression product of either a plasmid designated pVg4:HuPRO140 HG2-VH (ATCC Deposit Designation PTA-4098) or a plasmid designated pVg4:HuPRO140 (mut B+D+I)-VH (ATCC Deposit Designation PTA-4099), or a fragment of such antibody, which fragment binds to CCR5 on the surface of a human cell, and (2) one or more anti-viral agent, under conditions effective to treat said HIV-1-afflicted subject.