Patent ID: 8957064
Filing Date: 2015-02-17
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) wherein ring B and the pyrimidine to which it is fused form a ring system selected from * marks the point of the attachment, R1 is hydrogen, 1-4C-alkyl optionally substituted by halogen, hydroxy, amino, mono- or di-1-4C-alkylamino, halogen, amino, —SR2, —SO—R2, SO R2 is hydrogen, 1-4C-alkyl optionally substituted by halogen, hydroxy, amino, mono- or di-1-4C-alkylamino, or 3-7C-cycloalkyl, R3 is hydrogen, 1-4C-alkyl or halogen, 1-4-Calkoxy R4 is phenyl, thienyl, pyridinyl, thiazolyl or oxazolyl and wherein R4 is optionally independently substituted one or two times by R5A, R5A is 1-4C-alkyl, halogen or 1-4C-alkoxy or NR10R11, R5 is hydrogen, 1-4C-alkyl, halogen, 1-4C-alkoxy, NR10R11 or 3-7C-cycloalkyl, R6 is hydrogen or 1-4C-alkyl, R7 is —W—Y, W is a monocyclic 5- or 6-membered heteroarylene comprising 1 nitrogen atom and optionally 1,2 or 3 further heteroatoms independently selected from oxygen, nitrogen and sulphur or a bicyclic heteroarylene comprising 1 nitrogen atom and optionally 1,2 or 3 further heteroatoms independently selected from oxygen, nitrogen and sulphur R8 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 1-4C-haloalkyl, NR10R11, 4C-alkoxy, cyano, halogen or hydroxy, Y is hydrogen, aryl or a monocyclic 5- or 6-membered heteroaryl comprising 1 nitrogen atom and optionally 1,2 or 3 further heteroatoms independently selected from oxygen, nitrogen, sulphur and wherein the aryl or heteroaryl is optionally substituted independently one or more times by R9 and optionally further substituted by R9A R9 is 1-4C-alkyl, 1-4C-alkoxy, halogen, hydroxy, 1-4C-haloalkyl, NR10R11, cyano, or —C(O)NH2 R9A is 1-4C-alkyl or halogen n is 1 or 2, m is 1 or 2, R10, R11 which can be same or different, is hydrogen, 1-4C-alkyl optionally substituted by halogen, hydroxy, amino, mono- or di-1-4C-alkylamino, or 3-7C-cycloalkyl, R12, R13 which can be same or different, is hydrogen, 1-4C-alkyl optionally substituted by halogen, hydroxy, amino, mono- or di-1-4C-alkylamino, or 3-7C-cycloalkyl, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.