Patent ID: 8691761
Filing Date: 2014-04-08
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A somatostatin antagonist that binds to SSTR2; is not significantly internalized into cells expressing SSTR2, and reduces octreotide-induced internalization of SSTR2, wherein the antagonist is a cyclic somatostatin (SRIF) peptide antagonist comprising the amino acid sequence (cyclo 3-14) Xaa 1 -Xaa 2 -D-Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 -Xaa 7 -Xaa 8 -Xaa 9 -Xaa 10 -Xaa 11 -Xaa 12 -Xaa 13 -Xaa 14 -Xaa 15 ; Xaa Xaa D-Xaa Xaa Xaa Xaa L or D-(DNP)His, L or D-Aph(Cbm); Xaa Xaa Xaa Xaa Xaa