Patent ID: 7507823
Filing Date: 2009-03-24
Classification: C07D,Y02P

Abstract:
1. A process for preparing a crystalline aripiprazole monohydrate from unprocessed aripiprazole comprising the steps of: (a) providing a first mixture comprising a solvent and unprocessed aripiprazole; (b) providing a second mixture comprising a supercritical fluid which is carbon dioxide, nitrous oxide, sulfur hexafluoride, xenon, ethylene, chlorotrifluoromethane, ethane, trifluoromethane, or combinations thereof and optionally a modifier, which modifier is either completely miscible with, or is at least partially soluble in both the supercritical fluid and water, and which modifier is methanol, ethanol, n-propanol (n-PrOH), isopropanol, n-butanol, iso-butanol, sec-butanol, tert-butanol, an aldehyde, acetone, dimethylsulfoxide, tetrahydrofuran (THF), dichloromethane, dimethyl formamide (DMF), or combinations thereof; (c) introducing water to the second mixture; (d) introducing the first mixture and the second mixture into a particle formation vessel, wherein the contacting of the first mixture with the second mixture produces crystalline aripiprazole monohydrate; and (e) recovering the crystalline aripiprazole monohydrate.