Patent ID: 7208623
Filing Date: 2007-04-24
Classification: A61P,C07C,C07D,C07F

Abstract:
1. A process for the manufacture of a compound of formula or a salt thereof or a lactone thereof, wherein the element represents —CH 2 —CH 2 — or —CH═CH— and R represents a cyclic residue, comprising (a) reacting a compound of formula (II a)  wherein R  with a compound of formula R—CH(═O) (II b) wherein R represents a cyclic residue; and (b) reducing a resulting compound of formula (II c)  wherein R and R  wherein M is Ru, Rh, Ir, Fe, Co or Ni; L L Hal is halogen; R each of R each of R R wherein any aromatic residue of a compound of formula (IId), (IId′), (IId″), (IId′″), (IId″″), (IId′″″), (IId″″″) or (IID′″″″) is unsubstituted or substituted; wherein for compounds of formula (IId″), (IId′″), (IId″″), (IId′″″), (IId″″″) or (IID′″″″) also combinations with (R)— or (S)-BINAP are possible; and (c) condensing a resulting compound of formula (II e)  wherein R and R  with a compound of formula (II f)  wherein R (d) reducing a resulting compound of formula (II g)  wherein R and R (e) hydrolysing a resulting compound of formula (II h)  wherein R and R (f) isolating a resulting compound of formula (I) or a salt thereof; optionally, converting a resulting free acid of formula (I) into a salt thereof or into a lactone of formula (I a) or (I b), respectively,  or converting a resulting compound of formula (I) wherein the element  represents —CH═CH— into a compound of formula (I) wherein the element  represents —CH