Patent ID: 6982331
Filing Date: 2006-01-03
Classification: C07D

Abstract:
1. A method of synthesizing 4,6-dichloropyrimidine, 5-substituted-4,6-dichloropyrimidines, 4-chloro-6-hydroxypyrimidine, or 5-substituted-4-chloro-6-hydroxypyrimidines, said method comprising reacting a first imidoyl chloride compound represented by the formula: wherein R 2 is hydrogen, C 1-4 alkoxycarbonyl, C 1-4 alkoxysulfinyl, trimethylsilyl or a group —C(OH)′R″ wherein R′ and R″ are independently hydrogen, C 1-4 alkyl or phenyl, and a second imidoyl chloride compound which has two alpha hydrogens represented by the formula: wherein R 1 is selected from hydrogen and a C 1 -C 12 hydrocarbyl group, with phosgene, diphosgene, triphosgene or oxalyl chloride.