Patent ID: 8927724
Filing Date: 2015-01-06
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound of Formula (A-I) or a pharmaceutically acceptable salt thereof: wherein R* is selected from and R a. wherein R R 3* is selected from hydrogen, (C 1 -C 3 )-alkyl, aminoalkyl, aminocycloalkyl, hydroxyalkyl, each of R n is selected from 1, 2, 3 and 4, and m is selected from 1, 2 and 3; b. wherein R wherein each of R 4* , R 5* , R 6* and R 7* is as described previously; c. wherein Z is selected from CR each of R 9 and R 10 is independently selected from H, NH 2 , —NH(C 1 -C 3 )-alkyl and wherein each of R 4* , R 5* , R 6* and R 7* is as described previously, alternatively, R R each of R 12 , R 13 and R 14 is independently selected from hydrogen, (C 1 -C 6 )-alkyl, amino alkyl, aminocycloalkyl, and hydroxyalkyl, provided that at least one of R 12 , R 13 and R 14 is hydrogen, R wherein each of R 4* , R 5* , R 6* and R 7* is as described previously, each of p* and q* is independently selected from 0, 1, 2 and 3, T is selected from NH and O, t is selected from 0, 1, 2, 3, and 4, and each of r and y is independently selected from 0 and 1; d. wherein R wherein each of R s is selected from 0 and 1, and, v is selected from 0, 1, 2, and 3; e. wherein R wherein each of R 4* , R 5* , R 6* and R 7* is as described previously, R w is selected from 0 and 1; f. wherein M is selected from NR wherein R where each of R 12 , R 13 and R 14 is as described previously, each of R wherein each of R 4* , R 5* , R 6* and R 7* is as described previously, and u is selected from 0, 1 and 2; and g.