Patent ID: 6303785
Filing Date: 2001-10-16
Classification: C07C,C07D

Abstract:
A compound of the formula ##STR49##wherein A is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being optionally substituted with one or two R.sub.2 groups;Y is H, alkyl of 1 to 10 carbons, benzyl, lower alkyl or halogen substituted benzyl, fluoro-substituted alkyl of 1 to 10 carbons, cycloalkyl of 3 to 6 carbons, lower alkyl substituted cycloalkyl of 1 to 6 carbons, Cl, Br, or I;Z is--C.ident.C--,--(CR.sub.1.ident.CR.sub.1).sub.n' where n' is an integer having the value 1-5,--CO--NR.sub.1 --,NR.sub.1 --CO--,--CO--O--,--O--CO--,--CS--NR.sub.1 --,NR.sub.1 --CS--,--CO--S--,--S--CO--,--N.ident.N--;R.sub.1 is independently H or allyl of 1 to 6 carbons;p is an integer having the values of 0 to 5;R.sub.2 is independently H, alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons;R.sub.3 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, alkylthio of 1 to 6 carbons or benzyl;m is an integer having the values 0 to 2;R.sub.4 is independently H, alkyl of 1 to 6 carbons, or F; fluorosubstituted alkyl of 1 to 6 carbons, or halogen;o is an integer having the values of 0 to 4;n is an integer having the values of 0 to 4, andR.sub.8 is H, alkyl of 1 to 6 carbons, --CH.sub.2 O(C.sub.1-6 -alkyl), or a cation of a pharmaceutically acceptable base.