Patent ID: 9073975
Filing Date: 2015-07-07
Classification: A61K,C07K

Abstract:
1. A compound of formula I, wherein X1 is —(C or X1 is  wherein n is 1, 2, 3 or 4; X2 is a covalent bond, —(C X3 is a covalent bond or phenyl, wherein phenyl is unsubstituted; or X2-X3 is —NH—C(O)— or —C(O)—NH—; X4 is —(C or X1-X2-X3-X4 is —(C R1 and R2 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-asparagine, L-aspartic acid, L-2,4-diaminobutyric acid, L-glutamine, L-histidine, L-leucine, L-serine or L-threonine, or a pharmaceutically acceptable salt or a (C R3 and R4 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-glutamic acid or a pharmaceutically acceptable salt or a (C R5 and R6 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-arginine, L-2,3-diaminopropionic acid, L-lysine or L-ornithine, or a pharmaceutically acceptable salt thereof; R7 and R8 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-alanine, L-2-aminobutyric acid, L-2-amino-4-methoxybutyric acid, L-2-amino-3-methoxypropionic acid, L-cyclohexylalanine, L-cyclohexylglycine, L-glutamine, L-isoleucine, L-leucine, L-methionine or L-norleucine; R9 and R10 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-alanine, L-arginine, L-2,3-diaminopropionic acid, L-glutamine or L-norvaline, or a pharmaceutically acceptable salt thereof; R11 and R12 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of 1-aminocyclohexane-1-carboxylic acid, L-cyclohexylalanine, L-cyclohexylglycine, L-isoleucine, L-leucine, L-neopentylglycine, L-norleucine or L-norvaline; R13 and R14 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-histidine, D-histidine, or L-ornithine, or a pharmaceutically acceptable salt or a (C R15 and R16 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-asparagine; R17 and R18 together with the carbon atom carrying them and the NH group and the CO group attached to the said carbon atom, form the residue of L-leucine; or a pharmaceutically acceptable salt thereof.