Patent ID: 6040302
Filing Date: 2000-03-21
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I ##STR28## wherein R.sup.1 and R.sup.2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy; andX is --CH.sub.2 CH.sub.2 --; andY is >N--CH.sub.2 -- wherein only the underscored atom participates in the ring system; andr is 1, 2 or 3; andZ is selected from ##STR29## wherein M.sub.1 and M.sub.2 independently are CH or N; andR.sup.5 is hydrogen, C.sub.1-6 -alkyl, phenyl or benzyl; andR.sup.3 is hydrogen, nitro or cyano in the six-membered rings and hydrogen, halogen, trifluoromethyl, nitro or cyano in the five-membered rings; andR.sup.4 is nitro, cyano, (CH.sub.2).sub.m COR.sup.11, (CH.sub.2).sub.m OH or (CH.sub.2).sub.m SO.sub.2 R.sup.11 in the six-membered rings and hydrogen, halogen, trifluoromethyl, nitro, cyano, (CH.sub.2).sub.m COR.sup.11, (CH.sub.2).sub.m OH or (CH.sub.2).sub.m SO.sub.2 R.sup.11 in the five-membered rings, wherein R.sup.11 is hydroxy, C.sub.1-6 -alkoxy or NHR.sup.12, wherein R.sup.12 is hydrogen or C.sub.1-6 -alkyl; and m is 0, 1 or 2;or a pharmaceutically acceptable salt thereof.