Patent ID: 6319496
Filing Date: 2001-11-20
Classification: A61K,A61P,C07K,C12N

Abstract:
A method for generating human cytotoxic T-cells specific for a human carcinoembryonic antigen comprising:(a) introducing a sufficient amount of a first pox virus vector to a host to stimulate production of cytotoxic T cells, wherein said first pox virus vector contains a DNA segment encoding a human carcinoembryonic antigen (CEA) operably linked to a promoter capable of expression in the host; and(b) at least one periodic interval thereafter introducing into the host additional antigen by a second pox virus vector of the genus different from said first pox virus vector wherein said vector contains the DNA segment encoding the human CEA or encoding a peptide comprising at least one of SEQ ID NOS: 1-7, or by adding to the host a human CEA or a peptide selected from the group consisting of SEQ ID NOS: 1-7.