Patent ID: 8906369
Filing Date: 2014-12-09
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method for inhibiting growth of tumor cells expressing Ovr110, said method comprising contacting the cells with an isolated monoclonal antibody or antigen binding fragment thereof in an amount effective to inhibit growth of the tumor cells, wherein said isolated monoclonal antibody or antigen binding fragment thereof competes with a reference antibody for binding to the epitope on Ovr110 bound by the reference antibody, said reference monoclonal antibody or antigen binding fragment thereof comprising: (a) a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2, 12, 22, 32 and 42; and (b) a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 7, 17, 27, 37 and 47.