Patent ID: 6559146
Filing Date: 2003-05-06
Classification: A61K,A61P,C07D

Abstract:
An aminophenoxyacetic acid derivative represented by the following formula (I): wherein:R1, R2, R3 and R4 are, independent from each other, hydrogen atom; halogen atom; hydroxyl group; alkoxy group which may be substituted; alkyl group which may be substituted; aryl group which may be substituted; or aralkyl group which may be substituted; R5, R6, R7 and R8 are, independent from each other, hydrogen atom; alkyl group which may be substituted; aryl group which may be substituted; or aralkyl group which may be substituted; E1 is group â€”NR9â€” (in which, R9 is hydrogen atom; alkyl group which may be substituted; aryl group which may be substituted; or aralkyl group which may be substituted); E2 is oxygen atom; sulfur atom; or group â€”NR10â€” (in which, R10 is hydrogen atom; alkyl group which may be substituted; aryl group which may be substituted; or aralkyl group which may be substituted); n is 0 to 5; X and Y are, independent from each other, connecting bond; alkylene group which may be substituted by hydroxyl group, cariboxyl group, oxo group or morpholinyl group; cycloalkylene group; alkenylene group which may be substituted by lower alkyl group; â€”NHCOâ€”; â€”CONHâ€”; or â€”SO2â€”; or â€”Xâ€”Yâ€” represents â€”CON(CH3)â€”; and Q is hydrogen atom; naphthyl group; phenyl group which may be substituted; phenoxy group which may be substituted; benzoyl group which may be substituted; pyridyl group which may be substituted; quinolyl group which may be substituted; isoquinolyl group which may be substituted; or benzimidazolyl group which may be substituted; (provided that in the case of E1 is nitrogen atom and E2 is oxygen atom, all of the groups of R1, R2, R3 and R4 do not represent a methyl group at the same time), or a pharmaceutically acceptable salt thereof.