Patent ID: 6350786
Filing Date: 2002-02-26
Classification: A61K,A61P

Abstract:
A pharmaceutical composition comprising a carrier and a water-soluble complex of a therapeutically active, stable amorphous compound selected from the group consisting of and a water-insoluble ionic polymer that has a molecular weight greater than about 80,000 D, a glass transition temperature equal to or greater than about 50Â° C. and is selected from the group consisting of polyacrylate, chitosan, carboxy vinyl polymers, polyvinly acetate phthalate, cellulose acetate phthalate, polycyanoacrylates, hydroxypropylmethyl cellulose phthalate, cellulose acetate terphthalate, hydroxypropyl methyl cellulose acetate succinate, carboxy methyl cellulose and low substituted hydroxy propyl cellulose, or a mixture of two or more above-described ionic polymers, wherein the therapeutically active compound is molecularly dispersed in the water-insoluble ionic polymer predominantly in amorphous form, as determined by powder X-ray diffraction, and is present in the resulting water-insoluble complex at not less than about 10%, by weight, and the water-insoluble ionic polymer is present in the water-insoluble complex at not less than about 20%, by weight.