Patent ID: 9090649
Filing Date: 2015-07-28
Classification: A61P,C07H,C12N

Abstract:
1. A hybridizable oligonucleotide pair for forming a duplex comprising a sense strand having a 5′ end and an antisense strand complementary to the sense strand, the sense strand comprising a region 19 to 23 residues in length complementary to the antisense strand and consisting of: a plurality of 2′F-ANA and 2′F-RNA nucleotides, wherein at least a portion of the 2′F-ANA and 2′F-RNA nucleotides are present in a first altimer and a second, smaller altimer where the first altimer is located closer to the 5′ end of the sense strand than the second altimer; and the antisense strand comprising a region 19 to 23 residues in length complementary to the sense strand and consisting of: a plurality of 2′F-RNA nucleotides or RNA nucleotides.