Patent ID: 8728453
Filing Date: 2014-05-20
Classification: A61K,C08G,C40B

Abstract:
1. A method of making a combinatorial library of biodegradable polymeric compositions, comprising the steps of: a. arming/derivatizing an active molecule and optionally a natural product with at least one hydrolysable linker having at least one reactive end group to form an armed/derivatized active molecule and optionally an armed/derivatized natural product; b. mixing predetermined stoichiometry of one or more monomers having at least two polymerizable functionalities with the armed/derivatized active molecule and optionally the armed/derivatized natural product to form mixtures; c. co-polymerizing the armed/derivatized active molecule and optionally the armed/derivatized natural product of the mixtures obtained in step (b) to form pools of pre-polymers; d. mixing and copolymerizing predetermined stoichiometry of the pre-polymers obtained in step (c) with selected monomers to obtain said polymeric compositions; e. treating said polymeric compositions with capping reagents to give a combinatorial library of biodegradable polymeric compositions, wherein the biodegradable polymeric compositions allow a predetermined loading of the active molecule or the armed active molecule by adjusting quantity of said active molecule or said armed active molecule in said mixture before subjecting the mixture to polymerization, and further wherein the active molecule is selected from the group consisting of drugs, nutraceuticals, and imaging agents, and the natural product is a naturally occurring plant polyphenol or derivative thereof; and wherein said reactive end groups and functionalities are selected from the group comprising thiol, allyl, amine, anhydride, azido, carboxy, epoxy, hydroxy, isocyanate, lactone, propargyl, thiocyanate, or vinyl.