Patent ID: 6750251
Filing Date: 2004-06-15
Classification: A61K,A61P,C07F

Abstract:
A pharmaceutical composition comprising:(a) a ruthenium (II) compound of formula (I): â€ƒwherein: R1, R2, R3, R4, R5, and R6 independently represent H, alkyl, cycloalkyl, â€”CO2Râ€², aryl or alkylaryl, which latter two groups are optionally substituted on the aromatic ring; Râ€² represents alkyl, cycloalkyl, aryl or alkaryl; X is halo, H2O, (Râ€²)(Râ€³)SO, Râ€²CO2â€” or (Râ€²)(Râ€³)C&boxH;O, where Râ€³ represents alkyl, cycloalkyl, aryl or alkaryl; Y is counterion; m is 0 or 1; q is 1, 2 or 3; Câ€² is C1 to C12 alkylene or cycloalkylene, optionally substituted in or on the alkylene or cycloalkylene chain, bound to two A groups; p is 0 or 1 and r is 1 when p is 0 and r is 2 when p is 1; and p is 0, A is NR7R8 and B is NR9R10, wherein R7, R8, R9 and R10 independently represent H or alkyl, and A and B are linked by an alkylene or cycloalkylene chain, optionally substituted in or on the alkylene or cycloalkylene chain; or p is 1, A is NR7 and B is NR9R10, wherein R7, R9 and R10 are as previously defined, and A and B are linked by an alkylene or cycloalkylene chain, optionally substituted; and (b) at least one pharmaceutically acceptable excipient.