Patent ID: 7223760
Filing Date: 2007-05-29
Classification: A61P,B82Y,C07D

Abstract:
1. A compound of the formula: wherein R Y is X X R R Z is oxygen or sulfur; n is 0, or an integer having a value of 1 to 10; m is 0, or the integer 1 or 2; m′ is an integer having a value of 1 or 2, m″ is 0, or an integer having a value of 1 to 5; v is 0, or an integer having a value of 1 or 2; R 2 is hydrogen, —C(H)(A)(R 22 ), (CR 10 R 23 ) n OR 9 , (CR 10 R 23 ) n OR 11 , C 1-10 alkyl, halo-substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-10 alkyl, C 5-7 cycloalkenyl, C 5-7 cycloalkenyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclyl, heterocyclylC 1-10 alkyl, (CR 10 R 23 ) n S(O) m R 18 , (CR 10 R 23 ) n NHS(O) 2 R 18 , (CR 10 R 23 ) n NR 13 R 14 , (CR 10 R 23 ) n NO 2 , (CR 10 R 23 ) n CN, (CR 10 R 23 ) n S(O) m′ NR 13 R 14 , (CR 10 R 230 ) n C(Z)R 11 , (CR 10 R 23 ) n OC(Z)R 11 , (CR 10 R 23 ) n C(Z)OR 11 , (CR 10 R 23 ) n C(Z)NR 13 R 14 , (CR 10 R 23 ) n C(Z)NR 11 OR 9 , (CR 10 R 23 ) n NR 10 C(Z)R 11 , (CR 10 R 23 ) n NR 10 C(Z)NR 13 R 14 , (CR 10 R 23 ) n N(OR 6 )C(Z)NR 13 R 14 , (CR 10 R 23 ) n N(OR 6 )C(Z)R 11 , (CR 10 R 23 ) n C(═NOR 6 )R 11 , (CR 10 R 23 ) n NR 10 C(═NR 19 )NR 13 R 14 , (CR 10 R 23 ) n OC(Z)NR 13 R 14 , (CR 10 R 23 ) n NR 10 C(Z)NR 13 R 14 , (CR 10 R 23 ) n NR 10 C(Z)OR 10 , 5-(R 18 )-1,2,4-oxadizaol -3-yl or 4-(R 12 )-5-(R 18 R 19 )-4,5-dihydro-1,2,4-oxadiazol-3-yl; and wherein the cycloalkyl, cycloalkyl alkyl, aryl, arylalkyl, heteroaryl, heteroaryl alkyl, heterocyclic and heterocyclic alkyl moieties may be optionally substituted; A is an optionally substituted aryl, heterocyclyl, or heteroaryl ring, or A is a substituted C R R R R R R R R R R R R R R R R R or a pharmaceutically acceptable salt thereof.