Patent ID: 6774132
Filing Date: 2004-08-10
Classification: A61P,C07D

Abstract:
A compound of the formula I in racemic form or in the form of an enantiomer, or a pharmaceutically acceptable salt thereof, whereinR1 is a) H, b) substituted or unsubstituted C1-C6 alkyl, c) C1-C6 alkoxy C1-C6 alkyl, d) C1-C6 alkylthio C1-C6 alkyl, e) halogenated C1-C6 alkyl, f) aryl C1-C6 alkyl, g) C1-C6 alkenyl, or h) C1-C6cycloalkyl C1-C2 alkyl; R2 is a) H, b) C1-C6 alkyl, c) C2-C4 alkynyl, d) halogen, e) substituted or unsubstituted carbamoyl, f) substituted or unsubstituted carbamoyloxy, g) C1-C6 alkylcarbonyl, h) C1-C6 alkoxycarbonyl, i) C1-C6 alkylcarbonyloxy, j) hydroxy-substituted C1-C6 alkyl, k) cyano, l) nitro, m) amino, n) halogenated C1-C6 alkyl, o) halogenated C1-C6 alkoxy, p) halogenated C1-C6 alkylthio, q) C1-C6 alkylsulfinyl, r) C1-C6 alkylsulfonyl, s) C1-C4 alkylsulfinylalkyl, t) C1-C4 alkylsulfonylalkyl, u) C1-C6 alkylsulfonylamino, v) halogenated C1-C6 alkylsulfonylamino, w) halogenated C1-C2 alkylsulfonyloxy, x) aminosulfonyl, y) aminosulfonyloxy, z) aryl, aa) arylcarbonyl, bb) arylsulfinyl, cc) arylsulfonyl, dd) C1-C6 alkylcarbonylamino, ee) C1-C6 alkoxycarbonylamino, ff) C1-C6 alkyl-thiocarbonyl, gg) C1-C6 alkoxy-thiocarbonyl, hh) formyl, or ii) alkoxysulfonylamino; R3 is a) H, b) C1-C6 alky, c) halogen, d) C1-C6 alkoxy, e) halogenated C1-C4 alkyl, f) halogenated C1-C6 alkoxy, g) halogenated C1-C6 alkylthio, h) C1-C4 aksulfinyl, i) C1-C4 alkylsulfonyl, j) C1-C4 alkylsulfinyl C1-C6 alkyl, k) C1-C4 alkylsulfonyl C1-C6 alkyl, l) C1-C4 alkylsulfonylamino, m) halogenated C1-C4 alkylsulfonylamino, n) aminosulfonyl, or o) aminosulfonyloxy; R4 is a) H, b) C1-C4 alkyl, or c) halogen; R2 and R3 may together with the carbon atoms to which they are attached form a saturated or unsaturated ring, optionally substituted with one or more substituents selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, CF3, OH, cyano, amino, C1-C6 alkyl-NHâ€”, (C1-C6 alkyl)2â€”Nâ€”, CN, NH2SO2, NH2COâ€”, or C1-C6 alkyl-COâ€”; and wherein any amino moiety in R2-R4 can optionally be substituted with one or two C1-C6 alkyl groups which may be part of a ring, Ar is a) benzene, or b) pyridine, X is a) â€”NHCOâ€”, b) â€”CONHâ€”, or c) â€”NHâ€”SO2â€”; Y is a single bond; and Z is â€”CH&boxH;CHCH2 and with the proviso that when R1 is a substituted or unsubstituted C1-C6 alkyl, then R2, R3 and R4 cannot all be hydrogen.