Patent ID: 6951942
Filing Date: 2005-10-04
Classification: A61P,C07D

Abstract:
1. A compound of Formula I or a pharmaceutically acceptable salt thereof, where the symbol, represents a single bond or a double bond, R (1) a covalent bond, (2) —O—, (3) —S(O) (4) —C(X)—, where X is O or S, (5) —N(R (6) —N(R (7) —X′C(X)— where X is previously defined and X′ is O or S, (8) —C(X)X′—, (9) —X′C(X)X″— where X and X′ are previously defined and X″ is O or S, (10) —N(R (11) —C(X)N(R (12) —N(R (13) —X′C(X)N(R (14) —SO (15) —N(R (16) —N(R where (6)-(16) are drawn with their right ends attached to R (1) —OH, (2) —OG where G is a —OH protecting group, (3) —SH, (4) —CO (5) alkoxylcarbonyl, (6) —CN, (7) halo, (8) haloalkoxy of one to twelve carbons, (9) perfluoroalkoxy of one to twelve carbons, (10) —CHO, (11) —NR (12) —C(X)NR (13) —OSO provided that when R (14) alkyl of one to twelve carbons, (15) alkenyl of two to twelve carbons, (16) alkynyl of two to twelve carbons, where (14), (15), and (16) can be substituted with 1, 2, or 3 substituents independently selected from (17) cycloalkyl of three to twelve carbons, (18) cycloalkenyl of four to twelve carbons, where (17) and (18) can be substituted with 1, 2, 3, or 4 substituents independently selected from (19) perfluoroalkyl of one to twelve carbons, (20) aryl, and (21) heterocycle where (20) and (21) can be substituted with 1, 2, 3, 4, or 5 substituents independently selected from R R L -L  where d is 1, 2, 3, or 4 and A is selected from R R a broken line represents the optional presence of a double bond, provided that when R Y is selected from carbon, nitrogen, and N R provided that when the double bond is present, and Y is nitrogen or N R R