Patent ID: 8088160
Filing Date: 2012-01-03
Classification: A61F,A61L,C07K,C12N

Abstract:
1. A method of treating a vascular disease or disorder by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention, the method comprising: a) placing a stent within a vessel of a subject in need thereof, wherein said stent is coated with a biodegradable drug-eluting polymer that is impregnated with an inhibitor of smooth muscle cell proliferation and a growth factor for enhancing endothelial cell proliferation, wherein said inhibitor of smooth muscle cell proliferation is fibulin-5 polypeptide or a nucleic acid encoding fibulin-5 polypeptide, and wherein said growth factor for enhancing endothelial cell proliferation is VEGF polypeptide or a nucleic acid encoding VEGF polypeptide, wherein said fibulin-5 and said VEGF are released by degradation of said polymer; and b) eluting said inhibitor and said growth factor from said stent, thereby inhibiting smooth muscle cell proliferation and enhancing endothelial cell proliferation, and treating said vascular disease or disorder.