Patent ID: 7153683
Filing Date: 2006-12-26
Classification: A61K,C12N

Abstract:
1. An isolated polynucleotide encoding a polypeptide comprising: (a) a polypeptide variant of TAO1 kinase, comprising an amino acid sequence that comprises residues 1–416, 1–320, or 15–285 of SEQ ID NO:2, wherein the variant retains an ability to phosphorylate MEK3 that is at least 90% of the ability of a native TAO1 kinase to phosphorylate MEK3 under the same conditions, with the proviso that the variant does not comprise more than 500 consecutive amino acids of SEQ ID NO:2; or (b) a polypeptide variant of TAO2 kinase, comprising an amino acid sequence that comprises residues 1–416, 1–320, or 15–285 of SEQ ID NO:4, wherein the variant active retains an ability to phosphorylate MEK3 that is at least 90% of the ability of a native TAO2 kinase to phosphorylate MEK3 under the same conditions, with the proviso that the variant does not comprise more than 500 consecutive amino acids of SEQ ID NO:4.