Patent ID: 6077823
Filing Date: 2000-06-20
Classification: A01N,A61F,A61K,A61L,C07K,G01N

Abstract:
A method for treating immune cell mediated inflammatory or fibrogenic response, the method comprising:administering a morphogen other than TGF-.beta..sub.2 to tissue affected by immune cell mediated inflammatory or fibrogenic response, said morphogen comprising a dimeric protein having an amino acid sequence selected from the group consisting of(i) a sequence having at least 70% amino acid sequence homology with the C-terminal seven cysteine skeleton of human OP-1, amino acids 38-139 of Seq. ID No. 5; and(ii) Generic Sequence 6, Seq. ID No. 31;wherein said morphogen induces endochondral bone formation in an in vivo assay.