Patent ID: 8324352
Filing Date: 2012-12-04
Classification: A61K,A61P,C07K

Abstract:
1. An isolated anti-inflammatory antibody which specifically binds to the N2 self-peptide, wherein the antibody comprises: a) an amino acid sequence comprising a variable heavy (VH) complementarity determining region (CDR) 1 selected from the group consisting of SEQ ID NO: 4 and 16; b) an amino acid sequence comprising a VH CDR2 selected from the group consisting of SEQ ID NO: 6 and 18; c) an amino acid sequence comprising a VH CDR3 selected from the group consisting of SEQ ID NO: 26 and 30; d) an amino acid sequence comprising a variable light (VL) CDR1 selected from the group consisting of SEQ ID NO: 10 and 22; e) an amino acid sequence comprising a VL CDR2 selected from the group consisting of SEQ ID NO: 12 and 24; and f) an amino acid sequence comprising a VL CDR3 selected from the group consisting of SEQ ID NO: 28 and 32.