Patent ID: 6809202
Filing Date: 2004-10-26
Classification: C07D,C40B

Abstract:
A compound having a structure corresponding to that shown in Formula II, below, or a pharmaceutically acceptable salt thereof: wherein:q is an integer that is one through seven; each of &boxH;Z1 and &boxH;Z2 is &boxH;O; x and y are one, and the sum of x+y is two; the dotted line between the carbon atom of Ra1 and Ra2 and the carbon atom of Rb1 and Rb2 indicates the presence or absence of one additional bond between those depicted carbon atom, so that when present, the additional bond is shown as a solid line, following usual conventions of organic chemistry, and Ra2 and Rb2 are absent; Ra2 and Rb2 are independently selected from the group consisting of a hydrido, C1-C10 alkyl, C1-C10 substituted alkyl, C1-C10 phenylalkyl, C7-C16 substituted phenyalkyl, phenyl, substituted phenyl, C3-C7 cycloalkyl, and a C3-C7 substituted cycloalkyl group, and each of Ra1 and Rb1 is independently a divalent carbon, nitrogen, oxygen or sulfur that together form a saturated or unsaturated mono- or bicyclic ring that contains 5- to 8-members in each ring and zero to three heteroatoms in each ring that are independently oxygen, nitrogen or sulfur, and wherein Ra2 and Rb2 are absent when a double bond is present between the depicted carbon atoms; R1 is selected from the group consisting of a hydrido, C1-C10 alkyl, C1-C10 substituted alkyl, C1-C10 phenylalkyl, C7-C16 substituted phenyalkyl, phenyl, substituted phenyl, C3-C7 cycloalkyl, and a C3-C7 substituted cycloalkyl group; R2 is selected from the group consisting of a C1-C10 alkyl, C2-C10 alkenyl, benzyl, substituted benzyl, naphthyl, and a substituted naphthyl group; R3 is selected from the group consisting of a hydrido, C1-C10 alkyl, C1-C10 substituted alkyl, C1-C16 phenylalkyl, C7-C16 substituted phenylalkyl, phenyl, substituted phenyl, C3-C7 cycloalkyl, and a C3-C7 substituted cycloalkyl group; R4 is selected from the group consisting of a hydrido, C1-C10 alkyl, C2-C10 alkenyl, C1-C10 substituted alkyl, C3-C7 substituted cycloalkyl, C7-C16 phenylalkyl, C7-C16 phenylalkenyl, C7-C16 phenylalkenyl and a C7-C16 substituted phenyl-alkenyl group; and R5 is selected from the group consisting of a hydrido, C1-C10 acyl, aroyl, C1-C10 alkylaminocarbonyl, C1-C10 alkylthiocarbonyl, arylaminocarbonyl, and an arylthiocarbonyl group.