Patent ID: 6610723
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of formula whereinA is phenyl, pyridin-2-yl, pyridin-3-yl, or piperidin-1-yl; R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl, cycloalkyl, lower alkenyl, trifluoromethyl, â€”O-trifluoromethyl, â€”S-trifluoromethyl, S-lower alkyl, lower alkoxy, â€”CHF2, â€”C(lower alkyl)F2, â€”OCHF2, phenyl, nitro, benzyloxy, hydroxy and amino, or alternatively, R1 and R2 together with the carbon atoms to which they are attached in any adjacent positions from a group selected from â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, â€”CH&boxH;CHâ€”CH&boxH;Nâ€”, â€”(CH2)3â€”, â€”Oâ€”CH2â€”Oâ€”, â€”Oâ€”CF2â€”Oâ€”, â€”CH2â€”Oâ€”CH2â€” and â€”CH2CH2â€”Oâ€”; R3 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, phenyl, S-lower alkyl, amino, lower alkyl-amino, â€”NHC(O)-lower alkyl and hydroxy-lower alkyl; R4 and R5 are each independently selected from hydrogen and lower alkyl, or alternatively, R4 and R 5 together with the carbon atoms to which they are attached form the group â€”(CH2)4â€”; R6 and R6â€² are each independently selected from hydrogen and lower alkyl; X is â€”N< or Y is &boxH;Nâ€”, â€”NHâ€”, â€”N&boxH;CHâ€” or â€”CH&boxH;; Z is â€”CR7&boxH;, â€”N&boxH;, â€”NR7â€”, â€”N&boxH;CR7â€”, &boxH;CHâ€”N&boxH;C(R7)â€” or &boxH;Nâ€”CH&boxH;CHâ€”; R7 is hydrogen, â€”CH2OH or lower alkyl; n is 0, 1 or 2; m is 0 or 1; and the dotted line may be 1, 2 or 3 bonds; and pharmaceutically acceptable acid addition salts thereof.