Patent ID: 9101603
Filing Date: 2015-08-11
Classification: A61K,C07K,C12N,C12Y

Abstract:
1. A method for reducing the risk of motility of premalignant cells of the lung, comprising a. isolating cells of the lung from a human subject; b. determining whether the cells are premalignant; c. if the isolated cells are premalignant, determining whether the level of mRNA encoding the cytochrome P450 1B1 (CYP1B1) protein or whether the level of the CYP1B1 protein is elevated in the isolated cells; d. if the level of mRNA encoding the CYP1B1 protein is elevated in the isolated cells, or if the level of CYP1B1 protein is elevated in the isolated cells, administering to the subject a flavonoid selected from the group consisting of hesperidin, hesperetin, diosmetin, diosmin, eriodictyol, and homoeriodictyol in an amount effective to inhibit the motility-promoting activity of CYP1B1 protein in premalignant cells of the lung in the subject, thereby reducing the risk that the premalignant cells will become motile.