Patent ID: 6297222
Filing Date: 2001-10-02
Classification: A61K,C07H,Y10S

Abstract:
An acyl derivative of 2'-deoxyadenosine, having the formula ##STR19##wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from(a) an unbranched fatty acid with 3 to 22 carbon atoms,(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine, provided that R.sub.2 is not derived from leucine and that R.sub.3 is not derived from glycine or threonine,(c) nicotinic acid, or(d) a dicarboxylic acid having 3 to 22 carbon atoms,provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, and where R.sub.3 is not H, then R.sub.1 and/or R.sub.2 may also be acetyl, or a pharmaceutically acceptable salt thereof.