Patent ID: 6300346
Filing Date: 2001-10-09
Classification: A61K

Abstract:
A method for treating a patient with precancerous lesions sensitive to a compound below, comprising administering to the patient a pharmacologically effective amount of a compound of Formula I: ##STR11##wherein:R.sup.1 and R.sup.5 are independently: hydrogen, lower alkyl;R.sup.2 and R.sup.3 are independently: hydrogen, lower alkyl, phenyl optionally substituted with lower alkyl or R.sup.7 ; where R.sup.7 is --OR.sup.8, --SR.sup.9, --S(O).sub.n R.sup.9, --CN, --CO.sub.2 R.sup.8, or halogen; where R.sup.8 is hydrogen or R.sup.9 ; and where R.sup.9 is lower alkyl. Further, R.sup.2 and R.sup.3 may be heteroaryl optionally substituted with lower alkyl or R.sup.7 ; or lower alkyl monosubstituted with optionally substituted phenyl or heteroaryl;R.sup.4 is hydrogen, lower alkyl, lower alkynyl, lower alkenyl, --OR.sup.8, --C(O)R.sup.8, --NO.sub.2, N(R.sup.8).sub.2, --NR.sup.8 C(O)R.sup.8, --R.sup.10 N(R.sup.8).sub.2, SO.sub.2 N(R.sup.8).sub.2 --SR.sup.9, --R.sup.10 OH, --S(O).sub.n R.sup.9, --CN, --CO.sub.2 R.sup.8, --CON(R.sup.8).sub.2, halogen, cycloalkyl, --R.sup.10, halogen, or cycloalkoxy; where R.sup.8 and R.sup.9 are defined hereinabove and R.sup.10 is lower alkyl;R.sup.6 is hydrogen or --OM;M is hydrogen, a pharmaceutically acceptable cation or --C(O)R.sup.11 ; where R.sup.11 is lower alkyl, or phenyl substituted with hydrogen, lower alkyl or R.sup.7 ;m is 0 to 4;n is 1 or 2;p is 0 to 2;Z is lower alkyl, NR.sup.12 R.sup.13 or OR.sup.13 ; where R.sup.12 is --OM or R.sup.13 ; R.sup.13 is hydrogen, lower alkyl, lower alkynyl, lower alkenyl, lower (substituted) alkyl-(substituted) aryl, amino, alkylamino, cycloalkyl, aryl, heteroaryl, adamantyl, substituted polyaminalkyl; orwhere R.sup.12 and R.sup.13 are joined to form a heterocyclic ring of 3 to 6 carbon atoms and 1 or 2 heteroatoms selected from N, S or O, provided that R.sup.12 is --OM when R.sup.1 is hydrogen or n is 0;and the dotted line between positions 3 and 3' indicates an optional double bond.