Patent ID: 6043364
Filing Date: 2000-03-28
Classification: C07D

Abstract:
A process for converting a N-7 isomer of the formula: ##STR15## into a N-9 isomer of the formula: ##STR16## wherein R1 and R2 in formulae 1 and 2 are defined as (a) H and COCH.sub.3 ; (b) CH.sub.2 OCH.sub.2 Ph and CH.sub.2 Ph; or (c) CH.sub.2 OCOCH.sub.3 and COCH.sub.3 respectively, comprising:heating a suspension of the N-7 isomer of formula (1) in an alkylating agent of the formula: ##STR17## wherein R1 and R2 are as defined above, at a temperature of from 100.degree. C. to 110.degree. C. for 10 to 20 hours, in the absence of an acid catalyst and a solvent.