Patent ID: 8784891
Filing Date: 2014-07-22
Classification: A61K,A61L

Abstract:
1. An injectable graft composition for myocardial tissue regeneration, said composition comprising acellular heart extracellular matrix (ECM), said ECM comprising endogenous transforming growth factor beta (TGF-β) and fibroblast growth factor-2 (FGF-2), said ECM further comprising an exogenously added glycosaminoglycan (GAG), said GAG comprising at least 0.1% by weight of said composition, said GAG being linked to said ECM, wherein said GAG stimulates angiogenic effects of FGF-2 and interacts with TGF-β to control matrix formation and remodeling, wherein, when said composition is administered to damaged or diseased cardiovascular tissue, said composition induces stem cell proliferation and differentiation of stem cells into cardiomyocytes.