Patent ID: 6040327
Filing Date: 2000-03-21
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR11## wherein: R.sub.1 represents hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy (optionally substituted by aryl), trihalomethyl, cyano, sulpho, amino substituted by one or more, identical or different, linear or branched (C.sub.1 -C.sub.6)alkyl, optionally substituted aryl, acyl, arylsulphonyl and/or alkylsulphonyl), mercapto, linear or branched (C.sub.1 -C.sub.6)alkylthio, linear or branched (C.sub.1 -C.sub.6)trialkylammonium, aryloxy, arylthio wherein aryl is an aromatic group containing no hetero atoms, arylaminocarbonyl, arylcarbonylamino, arylsulphonylamino, arylaminosulphonyl, arylureido, arylthioureido, arylsulphonyl, arylsulphonyloxy, (C.sub.3 -C.sub.7)-cycloalkyloxy, (C.sub.3 -C.sub.7)cycloalkylthio, (C.sub.6 -C.sub.8)bicycloalkyloxy (optionally substituted by aryl), or (C.sub.6 -C.sub.8)bicycloalkylthio (optionally substituted by aryl), it being understood that each aryl is optionally substituted,Ra and Rb, which may be identical or different, represent hydrogen, hydroxy, or linear or branched (C.sub.1 -C.sub.6)alkyl (optionally substituted by aryl),X represents NR (wherein R represents hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl),R.sub.2 represents imidazolyl, benzimidazol-1-yl, naphthyl, pyridyl, thiazolyl, oxazolyl, benzothiazolyl, benzoxazolyl, pyrrolyl, furyl, thienyl, imidazopyridinyl, triazolyl, or tetrazolyl, each of those groups being optionally substituted by one or more, identical or different, halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)trihaloalkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, nitro, cyano, carboxy, linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl, hydroxy, amino (optionally substituted by one or more, identical or different, linear or branched (C.sub.1 -C.sub.6)alkyl, acyl, alkylsulphonyl, and/or arylsulphonyl), optionally-substituted phenyl, and/or optionally-substituted bicycloalkyl,R'.sub.2 represents hydrogen or optionally-substituted aryl,the term ""aryl group"" being understood to mean a mono- or bi-cyclic aromatic group optionally containing 1 to 4 hetero atoms selected from nitrogen, sulphur, and oxygen, and the term ""optionally substituted"" as applied to the aryl, phenyl and bicycloalkyl groups meaning a substitution of those groups by one or more, identical or different, halogen atoms, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)trihaloalkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy (optionally substituted by a carboxy or alkoxycarbonyl group), hydroxy, nitro, cyano, amino (optionally substituted by one or more, identical or different, linear or branched (C.sub.1 -C.sub.6)alkyl, acyl, alkylsulphonyl and/or arylsulphonyl groups), carboxy, linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl, hydroxyaminocarbonyl, alkylsulphonylamino, arylsulfonylamino, alkylsulphonylaminocarbonyl, arylsulphonylaminocarbonyl, optionally substituted phenyl, and/or optionally substituted bicycloalkyl groups,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base.