Patent ID: 7555392
Filing Date: 2009-06-30
Classification: G16B,Y10S

Abstract:
1. A method for determining a vector representing metabolic flux distribution of a cell, on a sufficiently programmed computer, comprising: creating a stoichiometric matrix based on formulas of biochemical reactions from a substrate to a product; computing a set of vectors of solutions existing in a stoichiometric matrix solution space; selecting, from the set of vectors of solutions, maximum vectors whose vector elements correspond to maximum input values for respective substances input values; performing a linear combination for the selected vectors in accordance with the following equations to obtain a vector representing metabolic flux distribution: S S(i): vector selected for substance for which inputted value can be obtained, A(i): adjustment vector, a, b: coefficients for linear combination (b may be 0), p: coefficient for obtaining consistency with input value as numerical value, q: coefficient of adjustment vector, and identifying and displaying the vector representing metabolic flux distribution.