Patent ID: 6096877
Filing Date: 2000-08-01
Classification: A61K,A61P,C07K,C12P,Y10S

Abstract:
An isolated recombinant cDNA molecule encoding a protein having Factor Xa inhibitory activity and having one or more NAP domains, wherein each NAD domain includes the sequence:Cys-A1-Cys-A2-Cys-A3-Cys-A4-Cys-A5-Cys-A6-Cys-A7-Cys-A8-Cys-A9-Cys-A10 [FORMULA II],wherein(a) A1 is an amino acid sequence of 7 to 8 amino acid residues;(b) A2 is an of 3 to 5 amino acid residues;(c) A3 is an amino acid sequence of 3 amino acid residues;(d) A4 is an amino acid sequence;(e) A5 is an amino acid sequence of 3 to 4 amino acid residues;(f) A6 is an amino acid sequence;(g) A7 is an amino acid residue;(h) A8 is an amino acid sequence of 11 to 12 amino acid residues;(i) A9 is an amino acid sequence of 5 to 7 amino acid residues; and(j) A10 is an amino acid sequence;wherein each of A2, A4, A6 and A10 has an independently selected number of independently selected amino acid residues and each sequence is selected such that each NAP domain has in total less than about 120 amino acid residues.