Patent ID: 8258289
Filing Date: 2012-09-04
Classification: A61P,C07H,C12N

Abstract:
1. A compound comprising a modified oligonucleotide consisting of 13 to 40 linked nucleosides and comprising a nucleobase sequence comprising a portion of at least 8 contiguous nucleobases complementary to an equal length portion of nucleobases 654 to 698, nucleobases 654 to 713, nucleobases 1197 to 1226, nucleobases 1309 to 1338, nucleobases 1110-1144, nucleobases 1309 to 1468, nucleobases 1197 to 1468, nucleobases 1387-1433, nucleobases 1309-1338, nucleobases 1469-1493, nucleobases 1635-1666, nucleobases 1707 to 1743, nucleobases 1763 to 1821, nucleobases 1946 to 1988, nucleobases 1946-2008, nucleobases 2055-2107, nucleobases 2067 to 2169, nucleobases 2125-2169, nucleobases 2220-2288, nucleobases 2220 to 2261 of the nucleic acid molecule encoding diacylglycerol acyltransferase 2 in SEQ ID NO: 4 or an exon:intron region, an intron:exon region, or an intron of the nucleic acid molecule encoding diacylglycerol acyltransferase 2 in SEQ ID NO:18, wherein the nucleobase sequence of the modified oligonucleotide is at least 95% complementary to SEQ ID NOS:4 or 18 over the entire length of the modified oligonucleotide.