Patent ID: 8912190
Filing Date: 2014-12-16
Classification: A61K,A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 1,3-dimethyl-7-(4-(trifluoromethoxy)phenyl)-quinoxalin-2(1H)-one; 1,3-dimethyl-6-[4-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 6-(3,4-difluorophenyl)-1,3-dimethylquinoxalin-2(1H)-one; 1-methyl-6-[4-(trifluoromethoxy)phenyl]-2-(trifluoromethyl)quinoxalin-2(1H)-one; 1,3-dimethyl-7-[4-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 1-methyl-7-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)quinoxalin-2(1H)-one; 1,3-dimethyl-7-[3-(trifluoromethyl)phenyl]quinoxalin-2(1H)-one; 1,3-dimethyl-7-[4-(trifluoromethyl)phenyl]quinoxalin-2(1H)-one; 3-tert-butyl-1-methyl-7-[4-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 3-tert-butyl-1-methyl-7-[3-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 1-methyl-3-(propan-2-yl)-7-[4-(trifluoromethoxy)phenyl]quinoxalin-2(H)-one; 1-methyl-3-(propan-2-yl)-7-[3-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 1,3-dimethyl-6-[3-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 1-methyl-6-[3-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)quinoxalin-2(1H)-one; 1-methyl-3-(trifluoromethyl)-6-[3-(trifluoromethyl)phenyl]quinoxalin-2(1H)-one; 1-methyl-7-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)quinoxalin-2(1H)-one; 1,3-dimethyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(H)-one; 7-(3,4-difluorophenyl)-1,3-dimethylquinoxalin-2(1H)-one; 1,3-dimethyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 7-(3,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one; 1,3-dimethyl-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1,3-dimethyl-7-(4-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one; 3-tert-butyl-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-isopropyl-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-isopropyl-1-methyl-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-7-(3-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)quinoxalin-2(1H)-one; 1-methyl-3-(trifluoromethyl)-6-(3-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one; 3-tert-butyl-1-methyl-6-(3-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one; 3-isobutyl-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 2-hydroxy-N-(2-{2-oxo-7-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)quinoxalin-1(2H)-yl}ethyl)acetamide; ethyl 4-methyl-3-oxo-6-[4-(trifluoromethoxy)phenyl]-3,4-dihydroquinoxaline-2-carboxylate; ethyl 4-methyl-3-oxo-6-[3-(trifluoromethoxy)phenyl]-3,4-dihydroquinoxaline-2-carboxylate; N-(2-{3-tert-butyl-2-oxo-7-[3-(trifluoromethoxy)phenyl]quinoxalin-1(2H)-yl}ethyl)-2-hydroxyacetamide; 3-(2-hydroxypropan-2-yl)-1-methyl-7-[4-(trifluoromethoxy)phenyl]quinoxalin-2(1H)-one; 2-hydroxy-N-(2-(2-oxo-7-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)quinoxalin-1(2H)-yl)ethyl)acetamide; 2-oxo-2-(2-(2-oxo-7-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)quinoxalin-1(2H)-yl)ethylamino)ethyl acetate; 2-hydroxy-N-(2-(3-t-butyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethyl)acetamide; 3-(2-hydroxypropan-2-yl)-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; tert-butyl 2-(3-tert-butyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)acetate; tert-butyl 2-(3-tert-butyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)acetate; 2-hydroxy-N-(2-(3-isopropyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethyl)acetamide; 2-hydroxy-N-(2-(3-isopropyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethyl)acetamide; 3-benzyl-1-methyl-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-tert-butyl-1-(2-methoxyethyl)-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-tert-butyl-1-(2-methoxyethyl)-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-3-phenyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-3-phenyl-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-isopropyl-1-(2-methoxyethyl)-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-isopropyl-1-(2-methoxyethyl)-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; ethyl 2-(4-methyl-3-oxo-6-(4-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxalin-2-yl)propanoate; ethyl 2-(4-methyl-3-oxo-6-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxalin-2-yl)propanoate; 2-(3-methyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)acetic acid; 3-(3-tert-butyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 2-(3-tert-butyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)acetic acid; 3-tert-butyl-1-(2-hydroxyethyl)-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; tert-butyl 3-(3-tert-butyl-2-oxo-6-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoate; 3-(3-tert-butyl-2-oxo-6-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 1-(2-hydroxyethyl)-3-isopropyl-7-(3-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; ethyl 4-(2,4-dimethoxybenzyl)-3-oxo-6-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxaline-2-carboxylate; 1-(2-hydroxyethyl)-3-isopropyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(3-isopropyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-tert-butyl-1-(2-hydroxyethyl)-6-(3-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one; ethyl 6-(3-bromophenyl)-4-(2,4-dimethoxybenzyl)-3-oxo-3,4-dihydroquinoxaline-2-carboxylate; 1-methyl-3-phenethyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(indolin-3-yl)-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(4-methyl-3-oxo-6-(4-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxalin-2-yl)propanoic acid; 3-(3-tert-butyl-7-(3-chlorophenyl)-2-oxoquinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-2-oxo-7-(4-phenoxyphenyl)quinoxalin-1(2H)-yl)propanoic acid; 4-((3-tert-butyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)methyl)benzoic acid; 2-(2-(3-isopropyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethoxy)acetic acid; 4-(3-methyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)butanoic acid; N-methyl-3-(4-methyl-3-oxo-6-(4-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxalin-2-yl)propanamide; 3-(3-isopropyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(3-methyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-benzoyl-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-isonicotinoyl-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(3-benzoyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 4-(3-methyl-2-oxo-7-(4-phenoxyphenyl)quinoxalin-1(2H)-yl)butanoic acid; 3-tert-butyl-1-methyl-7-(4-phenoxypiperidin-1-yl)quinoxalin-2(1H)-one; 3-hydroxy-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(3-benzyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(dimethylamino)-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 4-(3-tert-butyl-2-oxo-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)butanoic acid; 3-(3-methyl-2-oxo-7-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 1-methyl-3-(methyl(phenyl)amino)-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-3-(phenylthio)-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-3-phenoxy-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 1-methyl-3-(phenylamino)-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; N-(2-(3-methyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethyl)methanesulfonamide; N-(2-(3-isopropyl-2-oxo-7-(4-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)ethyl)methanesulfonamide; 3-(1H-imidazol-2-ylthio)-1-methyl-7-(4-(trifluoromethoxy)phenyl)quinoxalin-2(1H)-one; 3-(3-tert-butyl-2-oxo-7-(4-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-2-oxo-7-(3-phenoxyphenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-7-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoquinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-7-(2-methoxy-5-(trifluoromethyl)phenyl)-2-oxoquinoxalin-1(2H)-yl)propanoic acid; 3-(7-(3,5-bis(trifluoromethyl)phenyl)-3-tert-butyl-2-oxoquinoxalin-1(2H)-yl)propanoic acid; 3-tert-butyl-1-(2-hydroxyethyl)-7-(3-(trifluoromethyl)phenyl)quinoxalin-2(H)-one; 2-(3-tert-butyl-2-oxo-7-(3-phenoxyphenyl)quinoxalin-1(2H)-yl)acetic acid; 3-(3-tert-butyl-7-(3-(difluoromethoxy)phenyl)-2-oxoquinoxalin-1(2H)-yl)propanoic acid; 4-(3-tert-butyl-7-(4-chloro-3-(trifluoromethyl)phenyl)-2-oxoquinoxalin-1(2H)-yl)butanoic acid; 3-(3-tert-butyl-6-methoxy-2-oxo-7-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-7-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxoquinoxalin-1(2H)-yl)propanoic acid; (R)-3-(3-tert-butyl-2-oxo-7-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)butanoic acid; 3-(2-oxo-3-(2-phenylpropan-2-yl)-7-(3-(trifluoromethoxy)phenyl)quinoxalin-1(2H)-yl)propanoic acid; 3-(3-tert-butyl-6-methyl-2-oxo-7-(3-(trifluoromethyl)phenyl)quinoxalin-1(2H)-yl)propanoic acid; and ethyl 4-(2,4-dimethoxybenzyl)-3-oxo-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydroquinoxaline-2-carboxylate, or a pharmaceutically acceptable salt thereof.