Patent ID: 6218542
Filing Date: 2001-04-17
Classification: C07D

Abstract:
A process of preparing a mixture of cis- and trans-1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine(I-1) having a cis/trans ratio equal to or higher than 98.4/1.6 characterized in that ##STR6##compound (I-1), having a cis/trans ratio less than 98.4/1/6, is converted to an acid addition salt by treating said compound (I-1) with an inorganic acid selected from nitric acid and hydrochloric acid, in an appropriate solvent selected from isopropanol, n-butanol, MIK and toluene, yielding after crystallization compound (I-1-a), having a cis/trans ratio equal to or higher than 98.4/1.6.