Patent ID: 6998423
Filing Date: 2006-02-14
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound having the Formula I or a pharmaceutically acceptable salt or prodrug thereof pwherein either (i): B is N; A is (C Q is —(C —(C —X—(C —(C —(C —(C —(C —(C —(C —(C —(C —(C —(C W is oxy, thio, sulfino, sulfonyl, aminosulfonyl-, -mono-N—(C X is a five or six membered aromatic ring optionally having one or two heteroatoms selected independently from oxygen, nitrogen, and sulfur; said ring optionally mono-, or di-substituted independently with halo, (C Z is carboxyl, (C K is a bond, (C M is —Ar, —Ar said Ar, Ar R V is a bond or (C with the proviso that when K is (C or (ii): B is N; A is (C Q is —(C —(C —X—(C —(C —(C —(C —(C —(C —(C —(C —(C —(C —(C W is oxy, thio, sulfino, sulfonyl, aminosulfonyl-, -mono-N—(C X is a five or six membered aromatic ring optionally having one or two heteroatoms selected independently from oxygen, nitrogen, and sulfur; said ring optionally mono-, or di-substituted independently with halo, (C Z is carboxyl, (C K is (C M is —Ar, —Ar said Ar, Ar R V is a bond or (C with the proviso that when K is (C and with the proviso that 6-[(3-phenyl-propyl)-(2-propyl-pentanoyl)-amino]-hexanoic acid and its ethyl ester are not included or (iii): B is C(H); A is (C Q is —(C —(C —X—(C —(C —(C —(C —(C —(C —(C —(C —(C —(C —(C W is oxy, thio, sulfino, sulfonyl, aminosulfonyl-, -mono-N—(C X is a five or six membered aromatic ring optionally having one or two heteroatoms selected independently from oxygen, nitrogen and sulfur; said ring optionally mono-, or di-substituted independently with halo, (C Z is carboxyl, (C K is a bond, (C M is —Ar, —Ar said Ar, Ar R V is a bond or (C with the proviso that when K is (C