Patent ID: 7790406
Filing Date: 2010-09-07
Classification: G01N,Y10S

Abstract:
1. A method of conducting a cell-based assay of a sample comprising one or more cells, the method comprising the steps of: providing a grating-based biosensor substrate having a periodic surface grating structure wherein the periodic grating structure is constructed in a manner designed for both 1) optical interrogation of the sensor with light in an evanescent resonance (ER) detection mode, and 2) optical interrogation of the sensor with light in a label-free detection mode; depositing the sample onto the periodic grating structure; optically interrogating the sensor with light and using the biosensor to measure cell attachment of cells in the sample to the surface of the periodic grating structure in the label-free detection mode; depositing a drug compound candidate onto the periodic grating structure; and optically interrogating the sensor with light and using the biosensor to measure the effect of the drug compound candidate on cell function of the cells in the sample using the ER detection mode.