Patent ID: 6117888
Filing Date: 2000-09-12
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR28## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently selected fromhydrogen,-phenyl, unsubstituted or substituted with one or more ofC.sub.1-4 alkyl,C.sub.1-4 alkoxy,halogen,hydroxy,COOH, orCONH.sub.2,naphthyl,biphenyl,a 5- to 7-membered mono- or a 9- to 10-membered bicyclic heterocyclic ring which can be saturated or unsaturated, and which contains from one to four heteroatoms selected from the group consisting of N, O and S,--C.sub.1-7 alkyl, unsubstituted or substituted with one or more ofhydroxy,COOH,amino,aryl,C.sub.3-7 cycloalkyl,--CF.sub.3C.sub.3-7 cycloalkyl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl;or R.sup.1 and R.sup.2 together with the nitrogen to which they are bound form a 5- or 6-membered ring containing 1 nitrogen atom;R.sup.4 is hydrogen,--C.sub.1-4 alkyl,C.sub.3-7 cycloalkyl, ortrifluoromethyl.