Patent ID: 6958341
Filing Date: 2005-10-25
Classification: A61P,C07D

Abstract:
1. A compound of formula I: or a stereoisomer or pharmaceutically accetable salt thereof, wherein: R C C C C C C —NR —C(O)NR —O—C(O)C —XR wherein R R C C C C C C C —SO —SO —SO —NR -halogen, and —C(O)L wherein L is selected from C n is 0, 1 or 2; R R halogen, —CN, —S(O) —COR —CO —NR —N(COR —NR —NR —CONR 1-morpholinyl, 1-piperidinyl, 1-piperazinyl, and C wherein N R R R R wherein R R R R R R R R aryl is selected from phenyl, naphthyl, indanyl and indenyl, each aryl being substituted with 0-5 substituents independently selected at each occurrence from C heteroaryl is selected from the group pyridyl, pyrimidyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzothiazolyl, benzoxazolyl, isoxazolyl, triazolyl, tetrazolyl, indazolyl, 2,3-dihydrobenzo-furanyl, 2,3-dihydrobenzothienyl, 2,3-dihydro-benzothienyl-S-oxide, 2,3-dihydrobenzothienyl-s-dioxide, indolinyl, benzoxazolin-2-on-yl, benzodioxolanyl and benzodioxane, each heteroaryl being substitued at 0-4 carbon atoms with a substituent independently selected at each occurrence from the group C R R with the proviso that the compounds of Formula I with R (a) a compound of formula I wherein R (b) a compound of formula I, wherein R (c) a compound of formula I, wherein R (d) a compound of formula I, R (e) a compound of formula I, wherein R (f) in a compound of formula I, R (g) in a compound of formula I, R (h) in a compound of formula I, R (i) in a compound of formula I, R (j) in a compound of formula I, R (k) in a compound of formula I, R (l) in a compound of formula I, R (m) in a compound of formula I, R (n) in a compound of formula I, R (o) in a compound of formula I, R (p) in a compound of formula I, R (q) in a compound of formula I, R (r) in a compound of formula I, R (s) in a compound of formula I, R (t) in a compound of formula I, R (u) in a compound of formula I, R (v) in a compound of formula I, R (w) in a compound of formula I, R (x) in a compound of formula I, R