Patent ID: 7842697
Filing Date: 2010-11-30
Classification: A61P,C07D

Abstract:
1. A pyrazinoylguanidine compound represented by formula (I): wherein X is hydrogen, halogen, trifluoromethyl, lower alkyl, unsubstituted or substituted phenyl, lower alkyl-thio, phenyl-lower alkyl-thio, lower alkyl-sulfonyl, or phenyl-lower alkyl-sulfonyl; Y is hydrogen, hydroxyl, mercapto, lower alkoxy, lower alkyl-thio, halogen, lower alkyl, unsubstituted or substituted mononuclear aryl, or —N(R R each R wherein when two —CH R wherein each R wherein when two —CH each o is, independently, an integer from 0 to 10; each p is an integer from 0 to 10; with the proviso that the sum of o and p in each contiguous chain is from 1 to 10; each x is, independently, O, NR each R wherein when two —CH wherein when two R wherein when two —CH each R each R each R each R each Z is, independently, CHOH, C(═O), —(CH each R each R each R —(CH 2 ) m —(CHOR 8 ) m —(CH 2 ) m NR 7 R 10 , —(CH 2 ) m —NR 10 R 10 , —(CH 2 ) m —(CHOR 8 ) m —(CH 2 )mNR 7 R 7 , with the proviso that at least one R with the additional proviso that NR each Het is independently, —NR each g is, independently, an integer from 1 to 6; each m is, independently, an integer from 1 to 7; each n is, independently, an integer from 0 to 7; each Q is, independently, C—R each V is, independently, —(CH with the proviso that when V is attached directly to a nitrogen atom, then V can also be, independently, R wherein when two —CH or a stereoisomer thereof; or a pharmaceutically acceptable salt thereof.