Patent ID: 8110688
Filing Date: 2012-02-07
Classification: C07D

Abstract:
1. A production method of 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide represented by the following formula (i): comprising coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-ypacetaldehyde represented by the following formula (a): which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one represented by the following formula (a-6): with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide represented by the following formula (b):