Patent ID: 7888311
Filing Date: 2011-02-15
Classification: A61K,C07K,G01N

Abstract:
1. A method for the remediation of soil or fluid contaminated with uranium, comprising contacting soil or fluid contaminated with uranium with a reagent comprising a polypeptide, said polypeptide comprising one or more variants of the calmodulin loop of SEQ ID NO: 13, 14, 15 or 16, wherein the calmodulin loop variant comprises the mutation to neutral residues selected from the group consisting of Serine, Threonine, Cysteine, Histidine, Tyrosine, Asparagine and Glutamine of one or more residues selected from the Aspartic acid residues at positions 1 and 3 of SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15 and SEQ ID NO: 16 and the Aspartic acid residue at position 5 of SEQ ID NO: 13 and SEQ ID NO: 16, and wherein said calmodulin loop variant is flanked at both ends by an alpha helix.