Patent ID: 7652047
Filing Date: 2010-01-26
Classification: A61P,C07D

Abstract:
1. A method of inhibiting a MEK enzyme, comprising contacting the enzyme with an effective inhibitory amount of a compound of formula I wherein Ar and R or R A is O, S, CH or Ar where the five-membered ring is fused to Ar 1 and Y is NH, S, or O; or Ar 1 -A is where the dotted line represents an optional double bond, the five-membered ring is fused to Ar 1 , and R x is selected from substituents listed above for R 3 ; or Ar where the five-membered ring is fused to Ar 1 , and R x is selected from substituents listed above for R 3 ; Ar or Ar where R y is selected from substituents listed above for R 3 ; and R′ is OH; O—C or R′ is (CH or R′ is —CH(CH