Patent ID: 7879588
Filing Date: 2011-02-01
Classification: A61K,B82Y,Y10S

Abstract:
1. A composition comprising a hyperbranched polymer attached to a core and to a biologically active moiety, wherein the hyperbranched polymer contains at least two molecular chains, which molecular chains are of sufficient length to be so arranged as to form a cavity to accommodate the biologically active moiety, and wherein the molecular chains contain sterically demanding capping groups; further wherein the composition has the formula (V): wherein: (i) B is the core, containing at least one unit selected from the group consisting of >CH—, >C, and respective analogs thereof wherein H is replaced by an organic group, >N—, or >P—; (ii) each EMC is one of the at least two molecular chains and each comprises oxyethylene groups; (iii) L is a non-enzymatically cleavable linker and comprises a carbamate group; (iv) l is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; (v) P is the biologically active moiety and is a protein or polypeptide; and (vi) C is one or more of the capping groups, which comprises linear, branched, or cyclical alkyl groups, and optionally containing S, N, or O heteroatoms.