Patent ID: 8491457
Filing Date: 2013-07-23
Classification: A61F,A61K,A61L,B82Y

Abstract:
1. A method for producing a preconditioned blood vessel, comprising: providing a biocompatible matrix shaped in a tubular configuration seeded with a cultured population of endothelial cells on the inside surface of the matrix, wherein the tubular matrix comprises at least one nanoparticle coupled to a releasable therapeutic agent which is incorporated within the tubular matrix; attaching a first and second end of the tubular matrix to a first and second attachment element in a preconditioning chamber, wherein the first and second attachment elements have a channel that is fluidly coupled to a fluid flow system; and preconditioning the seeded tubular matrix with the flow system by moving a biological fluid through the seeded tubular matrix, wherein the flow-rate and pulse-rate of the biological fluid is controlled such that the preconditioned blood vessel is produced.