Patent ID: 6683029
Filing Date: 2004-01-27
Classification: A61P,C07D

Abstract:
A halogenopyrimidine of the formula (I) whereinZ represents (i) cycloalkyl having 3 to 7 carbon atoms that is optionally mono- or disubstituted by halogen, alkyl or hydroxyl; (ii) heterocyclyl selected from the group consisting of thienyl, pyridyl, and furyl, each of which is optionally substituted by alkyl having 1 to 4 carbon atoms or halogen; or (iii) phenyl or naphthyl, each of which is optionally mono- to tetra-substituted by identical or different substituents, where the substituents are selected from the group consisting of halogen; cyano; nitro; amino; hydroxyl; formyl; carboxyl; carbamoyl; thiocarbamoyl; straight-chain or branched alkyl, hydroxyalkyl, oxoalkyl, alkoxy, alkoxyalkyl, alkylthioalkyl, dialkoxyalkyl, alkylthio, mercaptoalkyl, alkylsulphinyl, or alkylsulphonyl having in each case 1 to 8 carbon atoms; straight-chain or branched alkenyl or alkenyloxy having in each case 2 to 6 carbon atoms; straight-chain or branched halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl, or halogenoalkylsulphonyl having in each case 1 to 6 carbon atoms and 1 to 13 identical or different halogen atoms; straight-chain or branched halogenoalkenyl or halogenoalkenyloxy having in each case 2 to 6 carbon atoms and 1 to 11 identical or different halogen atoms; straight-chain or branched alkylamino, dialkylamino, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylalkylaminocarbonyl, dialkylaminocarbonyloxy, alkenylcarbonyl, or alkynylcarbonyl, having 1 to 6 carbon atoms in the respective hydrocarbon chains; cycloalkyl or cycloalkyloxy having in each case 3 to 6 carbon atoms; doubly attached alkylene having 3 or 4 carbon atoms, oxyalkylene having 2 or 3 carbon atoms, or dioxyalkylene having 1 or 2 carbon atoms, each of which is optionally mono- to tetrasubstituted by identical or different substituents selected from the group consisting of fluorine, chlorine, oxo, methyl, trifluoromethyl, and ethyl; a grouping â€ƒin which A1 represents hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, or cycloalkyl having 1 to 6 carbon atoms, and A2 represents hydroxyl; amino; methylamino; phenyl; benzyl; optionally cyano-, hydroxyl-, alkoxy-, alkylthio-, alkylamino-, dialkylamino-, or phenyl-substituted alkyl or alkoxy having 1 to 4 carbon atoms; or alkenyloxy or alkynyloxy having in each case 2 to 4 carbon atoms; phenyl, phenoxy, phenylthio, benzoyl, benzoylethenyl, cinnamoyl, 1,3-dioxan-2-yl, benzimidazol-2-yl, dioxol-2-yl, oxadiazolyl, 2,3-dihydro-1,4-benzodioxin-6-yl, or benzo-dioxol4-yl, wherein each ring moiety is optionally mono- to trisubstituted by halogen and/or straight-chain or branched alkyl or alkoxy having 1 to 4 carbon atoms; and phenylalkyl, phenylalkyloxy, phenylalkylthio, 5,6-dihydro-1,4,2-dioxazin-3-ylmethyl, triazolylmethyl, or benzoxazol-2-ylmethyl, wherein the respective alkyl moieties have 1 to 3 carbon atoms and each ring moiety is optionally mono- to trisubstituted by halogen and/or straight-chain or branched alkyl or alkoxy having 1 to 4 carbon atoms; Q represents oxygen or sulphur; X represents fluorine, chlorine or bromine; and L1, L2, L3, and L4 are identical or different and independently of one another each represents hydrogen; halogen; cyano; nitro; or alkyl, alkoxy, alkylthio, alkylsulphinyl, or alkylsulphonyl having in each case 1 to 6 carbon atoms and being in each case optionally substituted by 1 to 5 halogen atoms.