Patent ID: 6303592
Filing Date: 2001-10-16
Classification: A61P,C07D

Abstract:
A compound of formula (1) ##STR11##wherein n is 0;R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting ofa) hydrogen;b) linear or branched C.sub.1 -C.sub.10 -alkyl;c) halogen;d) C.sub.1-10 -alkoxy;e) C.sub.2-10 -alkanoyloxy;f) C.sub.2-10 -alkene;g) C.sub.2-10 -alkene substituted with one or more groups selected from the group consisting of chlorine, fluorine, bromine or phenyl;h) C.sub.1-10 -alkoxycarbonyl;I) C.sub.1-10 -alkoxycarbamido;j) N--C.sub.1-10 -alkoxy-N--C.sub.1-10 -alkylaminocarbonyl;k) halo-C.sub.1-10 -alkyl;l) C.sub.6-10 -aryl;m) C.sub.6-10 -aryl; substituted with one or more groups selected from the group consisting of ethyl, n-propyl, isopropyl, amino, methylamino and dimethylamino;n) a C.sub.2 -C.sub.10 heterocycle having from 1-3 heteroatoms selected from the group consisting of O, N, and S;o) --COOH or --COOY, wherein Y is pharmaceutically acceptable cation; and,p) COMe;R.sub.3 is --CH.sub.2 M where M is selected from the group consisting ofa) C.sub.2-10 -acyloxy; andb) C.sub.2-10 -acyloxy substituted with one or more groups selected from the group consisting of --COOH, aminophenyl, phenyl, C.sub.1-6 -alkyl, chlorine, bromine or fluorine;R.sub.4 is selected from the group consisting ofa) hydrogen; and,b) pharmaceutically acceptable cations.