Patent ID: 6200996
Filing Date: 2001-03-13
Classification: A61K

Abstract:
A compound of the formula: ##STR28##where the C(.dbd.O)NHOH moiety and the --NR.sup.5 -- moiety are bonded to adjacent carbons of group A; whereinA is 5-6 membered heteroaryl having 1 to 3 heteroatoms selected from N, NR9, S and O;X is SO.sub.2 or --P(O)R.sub.10 ;Y is aryl or 5-10 membered mono- or bi-cyclic heteroaryl having from 1 to three heteroatoms selected from N, NR9, S and O, with the proviso that X and Z may not be bonded to adjacent atoms of Y;Z is O, NH, CH.sub.2 or S;R.sub.5 is hydrogen or alkyl of 1-6 carbon atoms;R.sub.6 and R.sub.7 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, --CN, --CCH;R.sub.8 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, 5 to 10 membered heteroaryl having 1 to 3 heteroatoms selected from N, NR9, S and O, or 5 to 9 membered heterocycloalkyl having 1 or 2 heteroatoms selected from N, NR9, S and O;R.sub.9 is hydrogen, aryl, alkyl of 1-6 carbon atoms or cycloalkyl of 3-6 carbon atoms;and R.sub.10 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, or heteroaryl; or a pharmaceutically acceptable salt thereof.