Patent ID: 6812226
Filing Date: 2004-11-02
Classification: A61P,C07D

Abstract:
A compound of formula (I): whereA is phenyl or a 5- or 6-membered heterocyclic ring having one or two heteroatoms selected from O, N or S; and optionally substituted by C1-6alkyl, halogen, nitro, amino, alkylamino, CF3, SO2Me, NHSO2Me or cyano; B is C&boxH;O, NH or SO2; X is O, (CH2)p where p is 1; Y is O, or CH2, provided that X and Y connot both be O or CH2; Z is C&boxH;O; R is hydrogen or C1-6alkyl; R1 is hydrogen, halogen; R2 is phenyl optionally substituted by CO2H, CO2alkyl, CONH2 or R2 is OH, NHR3, NHCH(R4)(CHR5)nR6, NHâ€”R7â€”R8, SO2NHalkyl, NHCOalkyl, NHSO2alkyl, morpholine, NR9R10, piperazine substituted by phenyl, alkoxyphenyl, pyridyl or fluorophenyl; n is 0, 1 or 2; R3 is hydrogen, a bi- or tricyclic saturated ring system optionally having a nitrogen atom, piperidinyl, alkylpyrollidine, ethynylcyclohexyl, a 5-membered aromatic ring having 2 or 3 heteroatoms selected from N or S, C4-6 cycloalkyl optionally substituted by alkyl, cyano or hydroxy, or C1-8 alkyl optionally having an oxygen atom in the alkyl chain and being optionally substituted by one or more substituents selected from ethynyl, cyano, fluoro, di-alkylamino, hydroxy, thioalkyl, CO2R11 or CONH2; R4 is hydrogen or alkyl optionally substituted by hydroxy or alkoxy; R5 is hydrogen or hydroxy; R6 is alkyl, CO2R11, NHCO2R12, CONH2 or a 5 or 6-membered saturated ring having an oxygen atom, a 5-membered heterocyclic ring having one or two heteroatoms selected from O, N or S, or phenyl optionally substituted by one or more groups selected from alkyl, hydroxy, amino, alkoxy, or nitro; R7 is a cyclopentane ring; R8 is phenyl; R9 and R10 are independently hydrogen, benzyl, alkenyl, cycloalkyl, alkyl optionally substituted by hydroxy, alkoxy, cyano, dialkylamino, phenyl, pyridyl or CO2R11 or R9 and R10 together form a 5- to 7-membered saturated or partially saturated ring optionally having a further heteroaton selected from O, N or S and optionally substituted by one or more groups selected from alkyl (optionally having an oxygen atom in the chain and optionally substituted by hydroxy), COalkyl, CO2R11, COR13R14, CHO or piperidine, R11 is hydrogen or alkyl; R12 is alkyl; and R13 and R14 are independently hydrogen or alkyl, or a pharmaceutically acceptable salt or solvate thereof.