Patent ID: 7504402
Filing Date: 2009-03-17
Classification: A61P,C07D

Abstract:
1. A method of treating a neurodegenerative disease wherein said neurodegenerative disease is selected from the group consisting of anxiety, or depression, in a mammalian patient comprising administering to the patient an effective amount of a compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein each p is independently 0, 1, or 2; each n is independently 0, 1, or 2; X is selected from the group consisting of a single bond, O, S(O) R in which aryl and heteroaryl are unsubstituted or substituted with one to three substituents independently selected from R R in which alkyl, alkenyl, and cycloalkyl are unsubstituted or substituted with one to three substituents independently selected from R each R R in which aryl, heteroaryl and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from R R wherein aryl, heteroaryl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C each R wherein alkyl and cycloalkyl are unsubstituted or substituted with one to five substituents independently selected from halogen, oxo, C aryl and heteroaryl are unsubstituted or substituted with one to three substituents independently selected from cyano, halogen, hydroxy, amino, carboxy, trifluoromethyl, trifluoromethoxy, C or two R each R