Patent ID: 6465478
Filing Date: 2002-10-15
Classification: A61P,C07D

Abstract:
A compound of the following formula: or its pharmaceutically acceptable salt, whereinR1 and R2, taken together with the carbon atom to which they are attached, form a mono-, bi-, or tri-cyclic group having 3 to 13 carbon atoms, wherein the cyclic group is optionally substituted by one to five substituents independently selected from halo, (C1-C4)alkyl, (C2-C4)alkenyl, (C1-C4)alkoxy, hydroxy, oxo, &boxH;CH2 and &boxH;CHâ€”(C1-C4)alkyl, provided that the bi- or tri-cyclic group is not a benzo-fused ring; A is (C2-C5)alkenyl, (C2-C5)alkynyl, phenyl-(C1-C5)alkyl, phenyl or heteroaryl selected from furyl, thienyl, pyrrolyl and pyridyl, wherein the phenyl and heteroaryl are optionally substituted by one to three substituents selected from halo, (C1-C3)alkyl and (C1-C3)alkoxy; R is hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, (C1-C6)alkanoyl, ((C1-C4)alkyl)-Zâ€”(C1-C6)alkynyl, ((C3-C7)cycloalkyl)-Zâ€”(C1-C6)alkyl, heterocyclic-(C1-C6)alkyl, phenyl-(C1-C6)alkyl, heterocyclic-(C1-C6)alkyl-Zâ€”(C1-C6)alkyl, phenyl-(C1-C6)alkyl-Zâ€”(C1-C6)alkyl, heterocyclic- Zâ€”(C1-C6)alkyl, ((C3-C7)cycloalkyl)-heterocyclic-(C1-C6)alkyl, heterocyclic-heterocyclic- Zâ€”(C1-C6)alkyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl and heterocyclic are optionally substituted by one to three substituents selected from halo, hydroxy, amino, guanizino, carboxy, amidino, ureido, (C1-C3)alkyl, (C1-C3)alkoxy, and mono- or di-(C1-C4)alkylamino, and wherein Z is O, S, SO, SO2, CO, C(&boxH;O)O, OC(&boxH;O), N(R), C(&boxH;O)N(R) or N(R)CO; and X is phenyl, heterocyclic, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C7)cycloalkyl, (C2-C7)alkynyl, wherein the phenyl, heterocyclic, alkyl, alkenyl, cycloalkyl and alkynyl are optionally substituted by one to three substituents selected from halo, (C1-C3)alkyl and (C1-C3)alkoxy.