Patent ID: 6372746
Filing Date: 2002-04-16
Classification: A61P,C07D

Abstract:
Acyl-piperazinyl-pyrimidines of formula (I) whereX is an oxygen or sulfur atom; R1 is a C1-4 alkoxy or trifluoromethyl radical; R2 is a C3-6 saturated cycloalkyl; heterocycloalkyl consisting of a ring of 3 to 6 atoms in which the heteroatom is selected from an atom of oxygen, sulfur or nitrogen, optionally N-substituted with C1-6 alkyl; phenyl optionally substituted with 1, 2 or 3 identical or different substituents selected from fluorine, chlorine, bromine, amino, acetamido, nitro, methyl, trifluoromethyl and methoxy; arylalkyl consisting of a C1-3 alkyl group substituted by a phenyl radical optionally substituted by 1, 2 or 3 identical or different substituents selected from fluorine, chlorine, bromo, amino, acetamido, nitro, methyl, trifluoromethyl and methoxy; heteroaryl consisting of a 5 or 6 heteroatom ring, optionally substituted, or of fused heteroaromatic systems optionally substituted, of 9 or 10 atoms consisting of 1 or 2 heteroatoms selected from oxygen, sulfur and nitrogen, selecting the aforementioned substituents from fluorine, chlorine, bromine, amino, acetamido, nitro, methyl, trifluoromethyl and methoxy; and heteroaryalkyl consisting of an alkyl group of 1 to 3 carbon atoms substituted with a heteroaryl radical consisting of a 5 or 6 member heteroaromatic ring, optionally substituted, or of fused 9 to 10 member heteroaromatic systems, optionally substituted with 1 or 2 heteroatoms selected from oxygen, sulfur and nitrogen, selecting the aforementioned substituents from fluorine, chlorine, bromine, amino, acetamido, nitro, methyl, trifluoromethyl and methoxy, with the proviso that R2 is not 3,4-dimethoxyphenyl; and their physiologically acceptable salts.