Patent ID: 7601687
Filing Date: 2009-10-13
Classification: A61P,C12Q,G01N

Abstract:
1. A method for identifying a test substance for the treatment of one or more of non-insulin dependent diabetes mellitus, beta cell dysfunction and peripheral insulin resistance comprising: a) culturing a transfected cell population that comprises reporter genes under the control of the insulin promoter and reporter genes under the control of the βGK promoter under conditions suitable for expression of the reporter genes, and contacting the transfected cells with a test substance; b) measuring the levels of reporter gene expression; c) identifying one or more positive test substances that increase the level of expression of the reporter genes under control of the βGK promoter and do not increase the level of expression of the reporter genes under control of the insulin promoter, and d) testing the one or more positive test substances for use in treating one or more of non-insulin dependent diabetes mellitus, beta cell dysfunction and peripheral insulin resistance.