Patent ID: 6077680
Filing Date: 2000-06-20
Classification: A61K,C07K,Y10S

Abstract:
A method of inhibiting Kv1 potassium channel activity in a lymphocyte cell of an animal, comprising providing to said animal an amount of a polypeptide composition effective to inhibit said channel activity in said cell wherein Arg11 of SEQ ID NO:1 is substituted with alanine, glutamine, glutamic acid; or Phe15 is substituted with alanine, tryptophan or p-azidophenalanine; or Lys22 is substituted with alanine, norleucine, ornithine, homocitrulline, arginine, phenylalanine, glutamic acid or diaminopinielic acid; or Tyr23 is substituted with alanine, glutamine, glutamic acid phenylalanine, cyclohexlalanine, p-benzoylphenylalanine, p-nitrophenylalanine or aminophenylalanine; or Leu25 is substituted with alanine.