Patent ID: 8329184
Filing Date: 2012-12-11
Classification: A61K,A61P,C07H,C12N,Y02A

Abstract:
1. A method of making an immunogenic composition comprising conjugating a saccharide to a protein carrier using carbodiimide condensation chemistry, wherein the saccharide comprises or has been derivatised to comprise, amino and/or carboxyl groups, and wherein the protein carrier comprises, or has been derivatised to comprise, amino and/or carboxyl groups, comprising the steps of: I)—if the protein carrier comprises both amino and carboxyl groups and the saccharide comprises either amino or carboxyl groups: II)—if the saccharide comprises both amino and carboxyl groups and the protein carrier comprises either amino or carboxyl groups: III)—if the saccharide comprises both amino and carboxyl groups and the protein carrier comprises both amino and carboxyl groups: