Patent ID: 7402298
Filing Date: 2008-07-22
Classification: A61K,C07K

Abstract:
1. A method of diagnosing breast cancer in a subject comprising the steps of: (a) administering to the subject an EphA2 monoclonal antibody or an antigen binding fragment thereof, wherein the monoclonal antibody is selected from group consisting of (i) monoclonal antibodies produced by hybridoma B13 (ATCC Accession number PTA-3711); and (ii) a monoclonal antibody obtained by humanizing the monoclonal antibody produced by hybridoma B13, where said humanized monoclonal antibody binds to an EphA2 receptor molecule; (b) detecting the EphA2 monoclonal antibody, or the fragment thereof, at a site within the subject, wherein the presence of the EphA2 monoclonal antibody, or the fragment thereof, at the site is indicative of breast cancer at that site.