Patent ID: 6255475
Filing Date: 2001-07-03
Classification: C07H,C12Q

Abstract:
A compound of the structure I: ##STR8##Or a salt thereof, whereinB is a nucleobase,X and Z independently are oxygen or sulphur,Y is hydrogen or a protected or unprotected hydroxy,R.sub.1 is hydrocarbyl, which optionally is substituted with a functional group selected from the group consisting of tertiary amino, nitro, cyano and halogen,R.sub.2 is hydrogen hydrocarbyl, which optionally is substituted with a functional group selected from the group consisting of tertiary amino, nitro, cyano and halogen,A is an electron withdrawing or electron donating group capable of moderating the acetyl stability of the compound I,L.sub.1 and L.sub.2 are hydrocarbon linkers, which may be the same or different, L.sub.2, when present, being either (I) connected to L.sub.1 via the group A, or (ii) directly connected to L.sub.1, the group A then being connected to one of linkers L.sub.1 and L.sub.2,F is a dye label,Q is a coupling group for F, andl, m and n independently are 0 or 1, with the proviso that l is 1 when m is 1, and l is 1 and m is 1 when n is 1.