Patent ID: 7514408
Filing Date: 2009-04-07
Classification: C07K,G01N

Abstract:
1. A compound capable of inhibiting β-secretase wherein the compound is of formula I: or a variant thereof in which any of V, A, E and F is/are replaced by a conservative substitution, wherein V, A, E and F are valine, alanine, glutamic acid and phenylalanine, respectively; R X is chosen from methionine, phenylglycine, n-leucine (n-Leu), asparagine, phenylalanine, glycine and valine; Z is chosen from valine, α-aminobutyric acid (Abu), phenylglycine (Phg) and alanine; and Y is statine, acha (cyclohexylmethylstatine) or phenylstatine (Phe-sta) wherein the phenyl group of phenylstatine optionally has mono or di-substitution chosen from the group consisting of Cl, F, Br, methyl and methoxy.