Patent ID: 6552009
Filing Date: 2003-04-22
Classification: A61K

Abstract:
A composition comprising a vitamin D analog and a retinoid, wherein:(a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and (b) the retinoid is selected from the group consisting of retinoid D with an alcohol CH2OH terminal side chain, an ester of retinoid D having an ester bond, an ether of retinoid D having an ether bond, and retinoid D where the alcohol CH2OH terminal side chain is replaced with an aldehyde CHO terminal side chain, wherein each of the ester bond and the ether bond is formed with the oxygen at the terminal side chain of Retinoid D and wherein said retinoid D with the alcohol CH2OH terminal side chain has the structure: wherein the configuration at the 7-, 9-, 11- and 13-position double bonds is independently Z or E and wherein R1 is selected from the group consisting of: wherein the keto group at the 4-position is free or protected; and wherein X is selected from the group consisting of hydrogen and C1-6-alkyl and Y is selected from the group consisting of hydroxy and C1-6-alkyoxyl and wherein the absolute configuration at the 4-position is independently R or S.