Patent ID: 6436939
Filing Date: 2002-08-20
Classification: A61K,A61P,C07D

Abstract:
A method for treating disorders mediated by the histamine H3 receptor in a patient, said method comprising administering to the patient a pharmaceutically effective amount of compound of formula (I):R is O or S; R1 is H, C1-4 alkyl, C1-4 alkoxy, Br, Cl, or I; R2 and R3 are H or â€”Oâ€”(CH2)mâ€”NR4R5, wherein one of R2 and R3 is H and the other is â€”Oâ€”(CH2)mâ€”NR4R5, when R3is â€”Oâ€”(CH2)mâ€”NR4R5, R2 is independently H, halogen, C1-4 alkyl, or C1-4 alkoxy; R4and R5 are the same or different, and are C1-5 alkyl, C3-6 cycloalkyl, benzyl, benzyl substituted by C1-4 alkyl, C1-4 alkoxy, Br, Cl, I, or R4 and R5 together with n are piperidyl, pyrrolidyl, imidazolyl, or n-substituted piperazyl, wherein the substituent is C1-4 alkyl, phenyl, or phenyl substituted with C1-3 alkoxy; n is 0 or1; m is 2-6; with the provisos that when at least one of R and R1 is Ar; and both of R and R1 are not Ar; or a pharmaceutically acceptable salt, ester, or amide thereof.