Patent ID: 9200382
Filing Date: 2015-12-01
Classification: B01J,B01L,C12N,C40B

Abstract:
1. A method of screening a library, the method comprising: contacting a library of candidate agents with a target in a reaction mixture under a condition of high stringency, wherein the condition of high stringency includes providing in the reaction mixture a total number of target molecules that is at least three orders of magnitude less than the total number of library members, wherein said library of candidate agents comprises at least 1,000 chemically distinct species, and wherein said target comprises a magnetic tag that responds to a controllable magnetic field applied to said magnetic tag; and passing the members of the library through a microfluidic device in a manner that exposes said members to said controllable magnetic field, wherein members of the library of candidate agents that are bound to the target are displaced relative to their unbound counterparts, and wherein the application of the controllable magnetic field provides for a partition efficiency which is greater than 10