Patent ID: 6790984
Filing Date: 2004-09-14
Classification: A61P,C07C

Abstract:
A process for stably purifying pravastatin sodium comprising the steps of:a. clarifying a fermentation broth containing pravastatin sodium by a step selected from centrifugation and filtration to obtain a clear solution containing the pravastatin sodium; and adjusting the clear solution to be basic having pH value ranging from pH 10Ëœ13; b. adsorbing the pravastatin sodium with non-ionic resin which is then washed with water; eluting the pravastatin sodium as adsorbed on the resin by water-soluble organic solvent, which is selected from: methanol, acetone and a mixture of methanol and acetone, to obtain pravastatin sodium fraction; and concentrating the fraction to be pravastatin sodium concentrate; c. treating the concentrate to form a precipitate of pravastatin sodium; and d. recrystallizing the precipitate for making pravastatin sodium crystal with high purity and high yield.