Patent ID: 9125814
Filing Date: 2015-09-08
Classification: A61K,A61L,C07D,C08G,C08J,C08L

Abstract:
1. A composition comprising a biocompatible hydrogel and an analgesic, wherein the analgesic is uniformly distributed in the hydrogel as in situ generated particles, and wherein the biocompatible hydrogel is produced by a method comprising: mixing a first compound and a second compound to obtain a first mixture, adding an acidic aqueous solution and the analgesic to the first mixture to obtain a first solution, adding a basic aqueous solution to the first solution, wherein, the first compound is a compound of Formula I: wherein each R each R R each R each n is independently an integer greater than 1; wherein at least one of R the second compound is a compound of Formula III: wherein each R each R each R each R each n is independently an integer greater than 1; wherein at least one of —R wherein the analgesic is a local anesthetic selected from the group consisting of bupivacaine, levobupivacaine, ropivacaine, lidocaine, mepivacaine, prilocaine, cinchocaine, etidocaine, articaine and salts thereof.