Patent ID: 6121449
Filing Date: 2000-09-19
Classification: A61P,C07J

Abstract:
A process for producing a compound of formula ##STR5## wherein the dotted lines - - - , independently from each other, represent a single or double bond;R and R.sub.1, which are the same or different, each represents hydrogen or a straight or branched C.sub.1 -C.sub.6, alkyl, phenylalkyl, alkylphenyl or alkylphenylalkyl group, the said alkyl groups being unsubstituted or substituted by one or more fluorine atoms;R.sub.2 is hydrogen or a C.sub.1 -C.sub.4 alkyl group optionally substituted by one or more fluorine atoms;R.sub.3, whenever present, is a hydrogen atom;provided that at least one of R and R.sub.1 contains one or more fluorine atoms and that, when the dotted line at position 5,6 represents a double bond, R3 is absent;which process comprises reacting an imidazolide derivative of formula ##STR6## wherein the dotted lines, R.sub.2 and R.sub.3 are as defined above, with an anhydrous acid in the presence of an amine of formulaHN(R)R.sub.1 (III)wherein R and R.sub.1 are as defined above; and, if desired, hydrogenating a resultant compound of formula (I) wherein one or both of the dotted lines represents a double bond.