Patent ID: 9028873
Filing Date: 2015-05-12
Classification: A61K,A61P,Y10S,Y10T

Abstract:
1. A nanoparticle for transport across the blood-brain barrier, comprising a polymeric resin, wherein said polymeric resin encapsulates a bis-quaternary pyridinium-2-aldoxime salt of the formula: wherein said nanoparticle has a largest size dimension of 1 nm to 999 nm and R wherein R1 and/or R2 comprise a functional group that provides partial negative polarity to thereby facilitate attraction to said pyridinium salt; and wherein said salt indicates one of the following: (a) a plurality of distinguishing x-ray diffraction peaks at 2 Theta angles of 10-35 degrees as compared to non-distinguishing x-ray diffraction peaks at 2 Theta angles of greater than 35 degrees, wherein said distinguishing x-ray diffraction peaks have relative intensity counts between 500-1500 at 2 Theta angles of 10-35 degrees and non-distinguishing x-ray diffraction peaks have relative intensity counts of less than 500 at 2 Theta angles of greater than 35 degrees and no peaks are present with relative intensity accounts of more than 250 at 2 Theta angles between 35-60 degrees and wherein said salt has a particulate structure and an aspect ratio of 2:1 to 16:1; or (b) a plurality of distinguishing x-ray diffraction peaks at 2 Theta angles of 10-45 degrees as compared to non-distinguishing x-ray diffraction peaks at 2 Theta angles greater than 45 degrees, wherein said distinguishing x-ray diffraction peaks have relative intensity counts between 500-1500 at 2 Theta angles of 10-45 degrees and non-distinguishing x-ray diffraction peaks have relative intensity counts of less than 500 at 2 Theta angles of greater than 45 degrees and no peaks are present with relative intensity accounts of more than 250 at 2 Theta angles between 45-60 degrees and wherein said salt has a particulate structure comprising a square, rectangular, rhomboid or rhombus geometry.