Patent ID: 6515191
Filing Date: 2003-02-04
Classification: C07B,C07C

Abstract:
A method for making aromatic compounds having two vicinal fluorine atoms comprising:(a) mixing an electrophilic fluorinating agent with a solution or suspension of a hydroxy aromatic compound in a polar aprotic solvent to form a difluoroketone derivative of an aromatic compound, said hydroxy aromatic compound having one, two or three rings, said rings being separate or fused and said rings optionally containing one or more heteroatoms and one or more substitutions in addition to hydroxy, said difluoroketone derivative having both fluorine atoms on a carbon vicinal to the ketone; (b) mixing a deoxofluorinating agent with the difluoroketone derivative of (a) in a solvent to form a tetrafluoro derivative of an aromatic compound; and (c) mixing the tetrafluoro derivative of an aromatic compound of (b) in an organic solvent with a reducing agent in aqueous ammonia to form an aromatic compound containing two vicinal fluorine atoms.