Patent ID: 7223558
Filing Date: 2007-05-29
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) a polynucleotide encoding the polypeptide of SEQ ID NO: 6 or the cDNA sequence contained In ATCC deposit No: PTA-4175, which is hybridizable under stringent conditions to the complement SEQ ID NO: 5, wherein said stringent hybridization conditions is incubation at 42 degree C. in 50% formamide, 5×SSC, 50 mM sodium phosphate, 5× Denhardt's solution, 10% dextran sulfate, and 20 μg/ml denatured, sheared salmon sperm DNA, followed by washing in 0.1×SSC at 65 degree C.; (b) an isolated polynucleotide comprising nucleotides 4 to 1770 of SEQ ID NO: 5, wherein said nucleotides encode the polypeptide corresponding to amino acids 2 to 590 of SEQ ID NO: 6, minus his start codon; (c) an isolated polynucleotide comprising nucleotides 1 to 1770 of SEQ ID NO: 5, wherein said nucleotides encode the polypeptide set forth in amino acids 1 to 590 of SEQ ID NO: 6 including the start codon; (d) a polynucleotide comprising nucleotides 88 to 1770 of SEQ ID NO: 5, wherein said nucleotides encodes the polypeptide of SEQ ID NO: 6 (e) a polynucleotide which is the complementary sequence (antisense) of SEQ ID NO: 5; and (f) a polynucleotide which is hybridizable under stringent conditions to any one of the polynucleotides specified in (a)-(e), wherein said stringent hybridization conditions is incubation at 42 degree C. in 50% formamide, 5× SSC, 50 mM sodium phosphate, 5× Denhardt's solution, 10% dextran sulfate, and 20 μg/ml denatured, sheared salmon sperm DNA, followed by washing in 0.1×SSC at 65 degree C., and wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues.