Patent ID: 8883777
Filing Date: 2014-11-11
Classification: A61K,A61P

Abstract:
1. A composition controlling a pH range of release and/or a release rate, which comprises (i) a thienotriazolodiazepine compound of the formula (I) wherein X is a halogen, R 1 is C1-C4 alkyl, R 2 is C1-C4 alkyl, a is an integer of 1-4, R 3 is C1-C4 alkyl, C1-C4 hydroxyalkyl, C1-C4 alkoxy, phenyl optionally having substituent(s), or heteroaryl optionally having substituent(s), a pharmaceutically acceptable salt thereof or a hydrate thereof; and (ii) at least one polymer selected from the group consisting of hydroxypropylmethylcellulose phthalate, methacrylic acid-methyl methacrylate copolymer and hydroxypropylmethylcellulose acetate succinate, which is a solid dispersion, and wherein the compound of the formula (I), a pharmaceutically acceptable salt thereof or a hydrate thereof is dispersed in the polymer.