Patent ID: 7186865
Filing Date: 2007-03-06
Classification: C07B,C07C

Abstract:
1. A process for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4, the process comprising the steps of: (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent represented by the formula 2, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, R Ar represents a phenyl group or 1- or 2-naphthyl group, and * represents a chiral carbon, wherein R wherein R, n, R wherein R, n, R