Patent ID: 6391882
Filing Date: 2002-05-21
Classification: A61P,C07D

Abstract:
A substituted 4-, 5-, 6-, or 7-indole or indoline derivative of Formula: wherein W is N and the dotted lines indicate optional bonds and wherein A is a group having the formula: whereinX is CR1A, CHR1A, N, NR1B, O, or S, where R1A is as defined for R3 to R9 below, and where R1B is as defined for R10 below; Y is CR2A, CHR2A, N, NR2B, O, or S, where R2A is as defined for R3 to R9 below and where R2B is as defined for R10 below, and the dotted lines indicate optional bonds; provided that X and Y are not both O or S; A is a group having the formula â€ƒwherein X is CR1A, CHR1A, N, NR1B, O, or S, where R1A is as defined for R3 to R9 below, and where R1B is as defined for R10 below; U is C, CH, or N; and the dotted lines indicate optional bonds; or A is a group having the formula â€ƒwhere U is C, CH, or N; Y is CR2A, CHR2A, N, NR2B, O, or S, where R2A is as defied for R3 to R9 below and where R2B is as defined for R10 below; and the dotted lines indicate optional bonds; n is 0, 1, 2, 3, 4, or 5, and m is 0, 1, 2, 3, 4, or 5; Z is CH2, O, S, CO, SO, or SO2, provided that if n is 0 then Z is CH2; R3-R9 and R11 to R12 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alkenyl, C1-6 alkynyl, C1-6 alkyl, C1-6 alkoxy, C1-6-alkylthio, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxycarbonyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkenyl, C3-8 cycloalkyl-C1-6-alkynyl, C3-8 cycloalkenyl-C1-6-alkyl, C3-8-cycloalkenyl-C1-6 alkenyl, C3-8-cycloalkenyl-C1-6-alkynyl, C1-6-alkylcarbonyl, phenylcarbonyl, halogen substituted phenylcarbonyl, trifluoromethyl, trifluoromethylsulfonyloxy, C1-6 alkylsulfonyl, aryl and heteroaryl, or two adjacent groups taken from R3-R9 may together form a methylenedioxy group, or two adjacent groups R7-R9 may together form a cyclopentyl or cyclohexyl ring which may be substituted with one more methyl groups, or one of R7-R9 may alternatively be a group â€”NR13R14 wherein R13 is as defined for R10 below and R14 is hydrogen, C1-6-alkenyl, C1-6 alkynyl, C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkenyl, C3-8 cycloalkyl-C1-6 alkynyl, C3-8 cycloalkenyl-C1-6-alkyl, C3-8-cycloalkenyl-C1-6 alkenyl, C3-8-cycloalkenyl-C1-6-alkynyl, aryl, heteroaryl, aryl-C1-6 alkyl, or heteroaryl-C-1-6-alkyl; R10 is hydrogen, C1-6-alkyl, C1-6-alkenyl, C1-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkenyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkenyl, C3-8-cycloalkyl C1-6-alkynyl, C3-8-cycloalkenyl C1-6-alkyl, C3-8-cycloalkenyl C1-6-alkenyl, C3-8-cycloalkenyl C1-6-alkynyl, aryl, heteroaryl, aryl-C1-6-alkyl, heteroaryl-C1-6-alkyl, acyl, thioacyl, C1-6-alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl, or heteroarylsulfonyl; R15VCOâ€” wherein V is O or S and R15 is C1-6-alkyl, C1-6-alkenyl, C1-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkenyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkenyl, C-3-8-cycloalkyl C1-6-alkynyl, C3-8-cycloalkenyl C1-6-alkyl, C3-8-cycloalkenyl C1-6-alkenyl, C3-8-cycloalkenyl C1-6-alkynyl, aryl, or heteroaryl; or a group R16R17NCO- or R16R17NCSâ€” wherein R16 and R17 are independently selected from hydrogen, C1-6-alkyl, C1-6-alkenyl, C1-6-alkynyl, C3-8-cycoalkyl, C3-8-cycloalkenyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkenyl, C3-8-cycloalkyl-C1-6 alkynyl, C3-8cycloalkenyl-C1-6-alkyl, C3-8-cycloalkenyl-C1-6alkenyl, C3-8-cycloalkenyl-C1-6-alkynyl, heteroaryl, or aryl, or R16 and R17 together with the N-atom to which they are linked, form a pyrrolidinyl, piperidinyl, morpholinyl, or perhydroazepin group; or an acid addition salt thereof.