Patent ID: 6652847
Filing Date: 2003-11-25
Classification: A61K,C12N,C12R,Y02A

Abstract:
An immunogenic composition comprising an attenuated strain of Leishmania wherein both wild-type copies of the gene encoding trypanothione reductase of the strain have been functionally disabled by mutagenesis thereof to provide a mutated strain having a reduced ability to infect or survive within macrophages in comparison to the native strain and a third copy of said gene encoding trypanothione reductase is present in the chromosome of the strain, wherein said strain is selected from the group consisting of Leishmania donovani, Leishmania braziliensis, Leishmania tarentolae Leishmania major, Leishmania mexicana, Leishmania tropica and Leishmania aethiopica.