Patent ID: 6541270
Filing Date: 2003-04-01
Classification: G01N,Y10T

Abstract:
A colorimetric detector for chemical and biological agents or toxins, comprising:a giant unilamellar vesicle (GUV) derived from 1,2 bis-(alkadiynoyl)-sn-glycero-3-phosphocholine (DCm,nPC) where m=2-16 and n=7-16, and m+n&gE;20 carbon atoms; wherein the GUV has a large radius of curvature of at least 50 microns; wherein the size of the GUV is from 10 to 300 microns; and wherein the GUV has a membrane bilayer that is polymerized by crosslinking acyl chains in the membrane bilayer to stabilize the GUV and to provide extended conjugated polymer backbone; and at least one incorporated molecular recognition site for said chemical and biological agents or toxins consisting of N-octadecyl maltobionamide (C-18 maltonamide) or N-octadecyl lactobionamide (C-18 lactonamide) wherein a colorimetric detection signal is produced when the chemical or biological agent or toxin binds with the molecular recognition site.