Patent ID: 6610663
Filing Date: 2003-08-26
Classification: A61K,C07H,C07J,C07K,C12N,C12Q,C12Y

Abstract:
A method for modulating the activity of RNA, comprising contacting said RNA with a composition comprising:a targeting portion specifically hybridizable with a preselected nucleotide sequence of the RNA; and a portion which is capable of cleaving a phosphodiester bond in said RNA and which comprises a compound of the structure: G0â€”G1â€”G2â€”G3 wherein:G0 is a nucleoside, a nucleotide or an oligonucleotide; G1 is a bivalent linking moiety; G2 is an aryl or heteroaryl moiety; and G3 is an RNA cleaving moiety having at least general acid/base properties.