Patent ID: 6521623
Filing Date: 2003-02-18
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein:R1 is C1-C6-alkyl substituted by a group selected from C1-C6-alkoxy, â€”OCONHC1-C6-alkyl, â€”NHSO2C1-C6-alkyl, and â€”NHCOC1-C6-alkyl; R2 and R3 together with the nitrogen form a saturated or unsaturated 5- or 6-membered heterocyclic ring optionally containing nitrogen or oxygen as an additional heteroatom, the heterocyclic ring thereof substituted by a group selected from phenyl, benzyl, and diphenylmethyl, each of these groups optionally mono- or di-substituted by one or two groups selected from CF3, C1-C4-alkyl, C1-C4-alkoxy, phenyl, benzyl, halogen, and OH, or R2 and R3 together with the nitrogen form a saturated or unsaturated 5- or 6-membered heterocyclic ring optionally containing nitrogen or oxygen as an additional heteroatom, the heterocyclic ring thereof linked via a single bond, a methylene-bridge, or spiro-connected to a saturated or unsaturated heterocyclic group containing one or two heteroatoms selected from oxygen and nitrogen, the heterocyclic group optionally mono- or di-substituted by a group selected from CF3, C1-C4-alkyl, C1-C4-alkoxy, phenyl, benzyl, halogen, &boxH;O, and OH, or R2 and R3 together with the nitrogen form a saturated or unsaturated bi- or tricyclic heterocyclic ring-system optionally containing nitrogen or oxygen as an additional heteroatom, the heterocyclic ring-system being optionally substituted by a group selected from CF3, C1-C4-alkyl, C1-C4-alkoxy, phenyl, benzyl, halogen, &boxH;O, and OH; and A is C1-C6-alkylene, C2-C6-alkenylene, or C2-C6-alkynylene, or a pharmaceutically acceptable salt thereof.