Patent ID: 6794406
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
Compounds of the general formula (I) in which Z represents O, S, SO, SO2, CH2, CHF, CF2 or represents NR9, in which R9 denotes hydrogen or (C1-C4)-alkyl, R1 and R2 are identical or different and represent hydrogen, halogen, cyano, (C1-C6)-alkyl, CF3, CHF2, CH2F, vinyl or (C3-C7)-cycloalkyl, where at least one of the two substituents is unequal to hydrogen and in the ortho position to the bridge bond, R3 represents a group of the formula â€”Amâ€”Dnâ€”Eoâ€”Gpâ€”Lâ€”R10, in which A represents O, S, NR11 or represents the group â€”(CR12&boxH;CR13)â€”, in which R11 denotes hydrogen or (C1-C4)-alkyl, and R12 and R13 are identical or different and denote hydrogen, cyano, (C1-C4)-alkyl or (C1-C4)-alkoxy, D represents a straight-chain (C1-C3)-alkylene group, which can be mono- or polysubstituted, identically or differently, by (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, halogen, amino, mono-(C1-C4)-alkylamino, mono-(C1-C4)-acylamino or (C1-C4)-alkoxycarbonylamino, E and L independently of one another represent a C(O) or SO2 group, G represents NR14, in which R14 denotes hydrogen or (C1-C4)-alkyl, or represents a straight-chain (C1-C3)-alkylene group, which can be mono- or polysubstituted, identically or differently, by (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, halogen, amino, mono- or di-(C1-C4)-alkylamino or mono-(C1-C4)-acylamino, m, n, o and p independently of one another in each case represent the number 0 or 1, with the proviso that in the case that L represents a C&boxH;O-group, the sum (m+n+o+p) is unequal to the number 0, and in the case that m and o in each case represent the number 1, A represents the radical NR11 and E and L in each case represent a C&boxH;O-group, the sum (n+p) is unequal to the number 0, and R10 represents OR15, NR16R17, (C1-C10)-alkyl, (C3-C8)-cycloalkyl, (C2-C6)-alkenyl, (C6-C10)-aryl, (C6-C10)-arylmethyl or represents a saturated, partly unsaturated or aromatic 5- to 10-membered heterocycle having up to four identical or different heteroatoms from the group consisting of N, O and/or S, where the abovementioned radicals are optionally substituted by one, two or three identical or different substituents selected from the group consisting of halogen, hydroxyl, oxo, cyano, nitro, amino, NR18R19, trifluoromethyl, (C1-C6)-alkyl, (C1-C6)-alkoxy optionally substituted by R20, (C3-C8)-cycloalkyl, (C6-C10)-aryl, which for its part is optionally substituted by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, trifluoromethyl, nitro or cyano; â€”Oâ€”C(O)â€”R21, â€”C(O)â€”OR22, â€”C(O)â€”NR23R24, â€”SO2â€”NR25R26, â€”NHâ€”C(O)â€”R27 and â€”NHâ€”C(O)â€”OR28, where R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27 and R28 are identical or different and in each case represent hydrogen, phenyl, benzyl, (C1-C6)-alkyl or (C3-C8)-cycloalkyl, which for their part are optionally mono- or polysubstituted, identically or differently, by halogen, hydroxyl, amino, carboxyl, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkoxy-carbonylamino, (C1-C5)-alkanoyloxy, a heterocycle or phenyl which is optionally substituted by halogen or hydroxyl, or the group â€”Lâ€”R10 represents a group of the formula â€ƒin which R29 denotes hydrogen or (C1-C4)-alkyl, or R3 represents a group of the formula â€ƒin which Q represents a 5- to 6-membered saturated, partly unsaturated or aromatic heterocycle having up to four identical or different heteroatoms from the group consisting of N, O and/or S, which for its part is optionally mono- to trisubstituted, identically or differently, by oxo (&boxH;O), thioxo (&boxH;S), hydroxyl, (C1-C6)-alkyl or phenyl, r represents the number 0, 1 or 2, and the ring Het denotes a 5- to 6-membered saturated or partly unsaturated heterocycle having up to three identical or different heteroatoms from the group consisting of N, O and/or S, which is optionally mono- to trisubstituted, identically or differently, by oxo (&boxH;O), thioxo (&boxH;S), hydroxyl, (C1-C6)-alkyl or phenyl, R4 and R5 are identical or different and in each case represent hydrogen, hydroxyl, halogen, cyano, nitro, (C1-C4)-alkyl or the radical of the formula NR30R31, where R30 and R31 have the meaning indicated for R15 and independently of one another can be identical to or different from this substituent, R6 represents hydrogen, halogen or represents a group of the formula â€”Maâ€”R32, â€ƒin which M represents a carbonyl group, a sulphonyl group or a methylene group, a represents the number 0 or 1, and R32 has the meaning of R10 indicated above and can be identical to or different from this substituent, R7 represents hydrogen or represents an acyl group which can be removed under physiological conditions with formation of an NH function, preferably represents hydrogen or acetyl, and R8 has the meaning of R6 indicated above and can be identical to or different from this substituent, and their pharmaceutically tolerable salts, solvates, hydrates and hydrates of the salts.