Patent ID: 7723312
Filing Date: 2010-05-25
Classification: A61K,A61P,C12N

Abstract:
1. A method for treatment of a cancer characterized by elevated expression of hsp27 as compared to non-cancerous tissue of the same type in an individual suffering from the cancer, comprising the step of administering to the individual a therapeutic composition effective to reduce the amount of active hsp27 in the cancer cells, wherein said therapeutic composition comprises an antisense oligonucleotide that is complementary to Seq. ID No. 91, and has sequence specificity for the coding sequence of hsp 27 including the translation initiation site to which Seq. ID Nos. 81 and 82 are complementary; wherein the antisense oligonucleotide is targeted to this region and wherein the antisense oligonucleotide consists of 12-35 nucleotides.