Patent ID: 6548535
Filing Date: 2003-04-15
Classification: A61K,Y10S

Abstract:
A method for treating ocular hypertension or glaucoma which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof: wherein,R1 is: R2 is: (a) CO2C1-6alkyl, (b) H, (c) OH, or R2 and R7 are taken together to form an oxirane ring when b is a single bond; R3 is: (a) H, or (b) (C&boxH;O)OC1-6alkyl; R5 is: (a) H, (b) OH, or (c) OC1-6alkyl; R7 is H, OC1-6 alkyl or R7 and R2 are taken together to form an oxirane ring when b is a single bond; Y is: (a) H, (b) OH, (c) OC1-6alkyl, or Y and R8 are joined such that one of the following rings is formed: R8 is C1-10 alkyl or C2-10 alkenyl; and _____ is a double bond optionally present at a or b or at both a and b.