Patent ID: 8249326
Filing Date: 2012-08-21
Classification: G01N,G06K,G06T

Abstract:
1. A method for assessing tissue pathology comprising: obtaining images of a plurality of cell nuclei in a tissue sample; computing values for a plurality of morphometric features of the plurality of cell nuclei, the morphometric features including one or more texture features; and, from the values of the morphometric features, computing a value for an index characterizing tissue of the tissue sample; and, recording the index value; wherein computing the value for the index comprises: computing discriminant scores for the plurality of nuclei based upon the values of the morphometric features for the nuclei; classifying the nuclei into a bins of a series of bins based upon the discriminant scores for the nuclei; and, computing the index value based upon the relative numbers of the nuclei classified in the bins; wherein the discriminant scores are based upon at least: a fractal area; a measure of skewedness, and a dimension of the nucleus; and, wherein a coefficient associated with the measure of skewedness is opposite in sign to coefficients associated with the fractal area and the dimension of the nucleus.