Patent ID: 6509001
Filing Date: 2003-01-21
Classification: A61K,A61P,C07K

Abstract:
A synthetic, calcitonin receptor-binding compound having a molecular weight of less than about 10,000 daltons and being covalently linked to a radiometal chelator to form a reagent wherein:said reagent has a binding affinity for a calcitonin receptor equal to or greater than the binding affinity of radioiodinated native calcitonin for said receptor; and the chelator is selected from the group consisting of: (a) diethylenetriaminepentaacetic acid (DTPA); (b) (HOOCCH2)3N(CR2)(CR2)N(CH2CoOH)(CR2)(CR2)N(CH2CoOH); where each R is independently H, C1 to C4 alkyl, or aryl and one R is covalently linked to a bivalent linker; (c) ethylenediaminetetraacetic acid (EDTA); (d) (HOOCCH2)2N(CR2)(CR2)N(CH2CoOH); where each R is independently H, C1 to C4 alkyl, or aryl and one R is covalently linked to a bivalent linker; (e) 1,4,7,10-tetraazadodecanetetraacetic acid; â€ƒwhere n is an integer that is 2 or 3 and where each R is independently H, C1 to C4 alkyl, or aryl and one R is covalently linked to the calcitonin receptor binding compound, and (g) desferrioxamine.