Patent ID: 8685447
Filing Date: 2014-04-01
Classification: A61K

Abstract:
1. A solid, compressed controlled release composition for oral administration of at least one pharmaceutically active agent, comprising: (a) a first layer comprising a first population of controlled release microparticles having a pharmaceutically active agent disposed therein; (b) a second layer comprising a pharmaceutically active agent disposed therein, wherein the second layer is adjacent the first layer; (c) a superabsorbent material comprising a cross-linked acrylic acid polymer characterized in that 1 gram of the cross-linked acrylic acid polymer absorbs at least 30 mL of water, wherein the superabsorbent material is disposed within the first layer, the second layer, or both the first layer and the second layer, wherein the superabsorbent material comprises from about 10% to about 50% w/w of the layer containing the superabsorbent material; (d) a controlled release agent disposed within the first layer, the second layer, or both the first layer and the second layer; and (e) the composition having a hardness from about 200 N to about 400 N, and wherein the composition,