Patent ID: 6548671
Filing Date: 2003-04-15
Classification: A61P,C07D

Abstract:
A compound of the formula or the pharmaceutically acceptable salt thereof; whereinR1 is quinoxalinyl optionally substituted with one or more substituents independently selected from the group consisting of hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl], (C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”,phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; R2 is phenyl-(CH2)mâ€”, naphthyl-(CH2)mâ€”, (C3-C10)cycloalkyl-(CH2)mâ€”, (C1-C6)alkyl or (C2-C9)heteroaryl-(CH2)mâ€”, wherein m is an interger from zero to four; wherein each of said phenyl, naphthyl, (C3-C10)cycloalkyl or (C2-C9)heteroaryl moieties of said phenyl-(CH2)mâ€”, naphthyl-(CH2)mâ€”, (C3-C10)cycloalkyl-(CH2)mâ€” or (C2-C9)heteroaryl-(CH2)mâ€”groups may optionally be substituted with one or more substituents independently selected from hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6) alkyl-HN(C&boxH;O )â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;C)â€”NH, (C1-C6)alkyl(C&boxH;C)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, phenoxy, benzyloxy, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; R3 is hydrogen, deuterium, (C1-C10)alkyl, (C3-C10)cycloalkyl-(CH2)nâ€”, (C2-C9)heterocycloalkyl-(CH2)nâ€”, (C2-C9)heteroayl-(CH2)nâ€” or aryl-(CH2)nâ€”; wherin n is an interger from zero to six; wherein said R3 (C1-C10)alkyl group may optionally be substituted with one or more substituents, independently selected from hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; and wherein any of the carbonâ€”carbon single bonds of said (C1-C10)alkyl may optionally be replaced by a carbonâ€”carbon double bond; wherein the (C3-C10)cycloalkyl moiety of said R3 (C3-C10)cycloalkyl-(CH2)nâ€”group may optionally be substituted by one to three substitutents independently selected from the group consisting of hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-c6)alkyl, H(O&boxH;C)â€”H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino (C1-C6)alkylamino [(C1-C6)alkyl]2amino, amino (C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O), H2N(C&boxH;O)â€”(C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl(S&boxH;O)â€”, (S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl,and (C2-C9)heteroaryl; wherein the (C2-C9)heterocycloalkyl moiety of said R3 (C2-C9)heterocycloalkyl-(CH2)nâ€” group has from one to three heteroatoms independently selected from nitrogen, sulfur, oxygen, >S(&boxH;O), >SO2 or >NR6, wherein said (C2-C9)heterocycloalkyl moiety of said (C2-C9)heterocycloalkyl-(CH2)nâ€” group may optionally be substituted on any of the ring carbon atoms capable of forming an additional bond with a substituent independently selected from the group consisting of hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkylHNâ€”SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; wherein the (C2-C9)heteroaryl moiety of said R3 (C2-C9)heteroaryl-(CH2)nâ€” group has from one to three heteroatoms independently selected from nitrogen, sulfur or oxygen wherein said (C2-C9)heteroaryl moiety of said (C2-C9)heteroaryl-(CH2)nâ€” group may optionally be substituted on any of the ring carbon atoms capable of forming an additional bond with a substituent selected from the group consisting of hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; and wherein said aryl moiety of said R3 aryl-(CH2)nâ€” group is optionally substituted phenyl or naphthyl, wherein said phenyl and naphthyl may optionally be substituted with from one to three substituents independently selected from the group consisting of hydrogen, deuterium, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl-Sâ€”, (C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6) alkyl-(S&boxH;O)â€”(C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; and R4 is (C2-C9)heteroaryl , (C2-C9)heterocycloalkyl, R5R6N-sulfonyl or a group of the formula wherein R5 is hydrogen, deuterium, (C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C&boxH;O)â€”, (C3-C10)cycloalkyl-(CH2)pâ€”, (C2-C9)heterocycloalkyl-(CH2)pâ€”, (C2-C9)heteroaryl-(CH2)pâ€”, phenyl-(CH2)pâ€”, or naphthyl-(CH2)pâ€”, wherein p is an integer from zero to four; wherein said (C2-C9)heterocycloalkyl, (C2-C9)heteroaryl, phenyl and naphthyl groups of said (C2-C9)heterocycloalkyl-(CH2)pâ€”, (C2-C9)heteroaryl-(CH2)pâ€”, phenyl-(CH2)pâ€”, or naphthyl-(CH2)pâ€” may be optionally substituted on any of the ring atoms capable of supporting an additional bond with a substituent selected from the group consisting of hydrogen, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy, optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6) alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6)alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl (C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; or R5 and R6 together with the nitrogen atom to which they are attached form a (C2-C9)heterocycloalkyl group wherein any of the ring atoms of said (C2-C9)heterocycloalkyl group may optionally be substituted with a substituent selected from the group consisting of hydrogen, halo, CN, (C1-C6)alkyl optionally substituted with one or more fluorine atoms, hydroxy, hydroxy-(C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with one or more fluorine atoms, (C1-C6)alkoxy(C1-C6)alkyl, HOâ€”(C&boxH;O)â€”, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”, HOâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-Oâ€”(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;O)â€”Oâ€”(C1-C6)alkyl, H(O&boxH;C)â€”, H(O&boxH;C)â€”(C1-C6)alkyl, (C1-C6) alkyl(O&boxH;C)â€”, (C1-C6)alkyl(O&boxH;C)â€”(C1-C6)alkyl, NO2, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, (C1-C6)alkylamino (C1-C6)alkyl, [(C1-C6)alkyl]2amino(C1-C6)alkyl, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€”, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”, H2N(C&boxH;O)â€”(C1-C6)alkyl, (C1-C6)alkyl-HN(C&boxH;O)â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”(C&boxH;O)â€”(C1-C6)alkyl, H(O&boxH;C)â€”NHâ€”, (C1-C6)alkyl(C&boxH;O)â€”NH, (C1-C6)alkyl(C&boxH;O)â€”[NH](C1-C6)alkyl, (C1-C6)alkyl(C&boxH;O)â€”[N(C1-C6)alkyl](C1-C6)alkyl, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-(S&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, (C1-C6)alkyl-SO2â€”NHâ€”, H2Nâ€”SO2â€”, H2Nâ€”SO2â€”(C1-C6)alkyl, (C1-C6)alkylHNâ€”SO2â€”(C1-C6)alkyl, [(C1-C6)alkyl]2Nâ€”SO2â€”(C1-C6)alkyl, CF3SO3â€”, (C1-C6)alkyl-SO3â€”, phenyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, and (C2-C9)heteroaryl; R6 is hydrogen, deuterium, (C1-C6)alkyl or amino; X is NR7 or S wherein R7 is defined as R4 above; and with the proviso that when R4 is a five-membered heterocyclic group, either R2 or R3 must be substituted by a functional group other than (C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkyl-(C&boxH;0)â€”Oâ€”, (C1-C6)alkyl-(C&boxH;0)â€”Oâ€”(C1-C6)alkyl, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, amino(C1-C6)alkyl, benzofuryl, indolyl, azacycloalkyl, azabicycloalkyl or benzopiperidinyl.