Patent ID: 6592885
Filing Date: 2003-07-15
Classification: A61F,A61K,A61L,Y10T

Abstract:
A method for making an infection-resistant fabricated textile article useful for biomedical applications in-vivo, said method comprising the steps of:obtaining a fabricated textile article comprised of at least one type of fiber matrices able to take up aqueous fluids; preparing at least a minimum inhibitory concentration of an aqueous antibiotic fluid consisting of water and at least one water-miscible antibiotic composition which has recognized antimicrobial properties, is heat stable and has a relative molecular mass in the 300-1500 range; perfusing said prepared antibiotic fluid across said fiber matrices of said fabricated textile article for a sufficient period of time such that said aqueous antibiotic fluid permeates at least some of said fiber matrices comprising said fabricated textile article; allowing said antibiotic perfused fabricated textile article to dry; and heating said dried antibiotic perfused fabricated textile article to an elevated temperature for a period of time sufficient to incorporate said antibiotic without substantive modification to said fiber matrices of said fabricated textile article such that said incorporated antibiotic retains its recognized antimicrobial activity and is sustainedly released from the fiber matrices over time.