Patent ID: 7799576
Filing Date: 2010-09-21
Classification: A61K,C07D,G01N,Y10T

Abstract:
1. A method for mass spectrometric analysis of isobarically labeled reactive peptides comprising: a) providing two or more samples, each sample comprising one or more reactive peptide analytes, b) reacting a first sample of the two or more samples with a first labeling reagent of a set of isobaric labeling reagents, c) reacting a second sample of the two or more samples with a second labeling reagent of the set of isobaric labeling reagents, the second labeling reagent differing isobarically from the first labeling reagent, wherein steps b) and c) thereby produce two or more differentially labeled samples each comprising one or more isobarically labeled peptide analytes, d) mixing together the two or more differentially labeled samples to form a sample mixture comprising two or more isobarically labeled peptide analytes of the formula: e) performing mass spectrometry on the sample mixture to analyze file isobarically labeled peptide analytes.