Patent ID: 7682602
Filing Date: 2010-03-23
Classification: A61K

Abstract:
1. A near-infrared fluorescent contrast medium comprising a cyanine compound represented by the following formula (I): wherein R is a hydrogen atom, a lower alkyl group or an aromatic group; R 1 and R 2 are each an aliphatic group containing a water-solubilizing group; R 3 and R 4 are each a lower alkyl group or an aromatic group, provided that R 3 and R 4 may combine with each other to form a carbocyclic ring; L 1 to L 6 are each a methine group, provided that when n is 1 or 2, L 6 combine with R 3 or R 4 to form a carbocyclic ring and when n is 0, L 4 may combine with R 3 or R 4 to form a carbocyclic ring; Z 1 and Z 2 are each a nonmetallic atom group necessary to form a 6-membered ring; X is a counter ion necessary to neutralize a charge of the molecule; p is the number of X necessary to neutralize a charge of the molecule; m is an integer of 2 to 4; and n is an integer of 0 to 2.