Patent ID: 8481782
Filing Date: 2013-07-09
Classification: C07B,C07C,C07F,Y02P

Abstract:
1. A method of preparing a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, comprising: reacting a compound represented by structural formula (I): with a compound represented by structural formula (a): to form a compound represented by structural formula (A): wherein: P R is —(CH X is COOR R m is 1, 2 or 3, wherein the process further comprises: (a) reacting the compound of structural formula (A) with a second alcohol protecting group to form a compound represented by structural formula (4): and (b) converting the compound of structural formula (4) to a tricyclic compound represented by structural formula (5): (c) hydrogenating the tricyclic compound of structural formula (5) to form a hydrogenated tricyclic compound represented by structural formula (6): and (d) converting the hydrogenated tricyclic compound represented by structural formula (6) to a compound represented by structural formula (IX): wherein said converting (d) accomplishes cleaving of the protective group P 1 and ester hydrolysis of R 1 in a single pot.