Patent ID: 8309593
Filing Date: 2012-11-13
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of treating polycystic kidney disease in a subject, the method comprising administering to the subject having polycystic kidney disease an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein X is —(CR X is —O—, —S— or —NR X is —(CR X is a covalent bond; and R R n is 1, 2, 3, 4, 5 or 6; and each R R 30 is i) hydrogen; ii) an aryl group optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl, amino, alkylamino, dialkylamino, alkoxy, nitro, cyano, hydroxy, haloalkoxy, alkoxycarbonyl, alkylcarbonyl and haloalkyl; or iii) an alkyl group optionally substituted with one or more substituents selected from the group consisting of halogen, amino, alkylamino, dialkylamino, alkoxy, nitro, cyano, hydroxy, haloalkoxy, alkoxycarbonyl, alkylcarbonyl and haloalkyl; each of A and B independently is halogen, hydroxy, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy or C1-C6 haloalkoxy; each k′ is independently 0, 1 or 2; each k″ is independently 0, 1 or 2; and each m′ is independently 0, 1 or 2.