Patent ID: 6162830
Filing Date: 2000-12-19
Classification: A61K,A61P,Y02A

Abstract:
A method of inhibiting PDE-IV or TNF comprising contacting a cell with a compound of the general formula ##STR7## wherein R.sub.1 and R.sub.2 represent C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.10 cycloalkyl; R.sub.3 and R.sub.4 independently represent C.sub.1-4 alkyl, cycloalkyl, C.sub.2 -C.sub.4 alkylenes having one double bond, C.sub.2 -C.sub.4 alkylynes having one triple bond, (CH.sub.2).sub.n CO(CH.sub.2).sub.m CH.sub.3, (CH.sub.2).sub.p CN, (CH.sub.2).sub.p CO.sub.2 Me, or taken together with nitrogen atom to which they are attached, form a 3- to 10-membered ring;n and m are 0 to 3;p is 1 to 3;and pharmaceutically acceptable salts thereof.