Patent ID: 6492381
Filing Date: 2002-12-10
Classification: A61K,C07D

Abstract:
A compound selected from a compound of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein:one of a, b, c and d represents N or NR9 wherein R9 is Oâˆ’, â€”CH3 or â€”(CH2)nCO2H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR32 or CR34; R32 and R34 are the same or different and each independently represents H, halo, â€”CF3, â€”OR10, â€”COR10, â€”SR10, â€”N(R10)2, â€”NO2, â€”OC(O)R10, â€”CO2R10, â€”OCO2R11, benzotriazol-1-yloxy, CN, alkynyl, alkenyl or alkyl, said alkyl or alkenyl group optionally being substituted with halo, â€”OR10 or â€”CO2R10; R36 and R38 are the same or different and each independently represents H, halo, â€”CF3, â€”OR10, â€”COR10, â€”SR10, â€”N(R10)2, â€”NO2, â€”OC(O)R10, â€”CO2R10, â€”OCO2R11, benzotriazol-1-yloxy, CN, alkynyl, alkenyl or alkyl, said alkyl or alkenyl group optionally being substituted with halo, â€”OR10 or â€”CO2R10, or R36 and R38 taken together can represent a saturated or unsaturated C5-C7 fused ring to the benzene ring (Ring III); R5, R6, R7 and R8 each independently represents H, â€”CF3, alkyl or aryl, said alkyl or aryl optionally being substituted with â€”OR10, â€”SR10, â€”N(R10)2, â€”NO2, â€”COR10, â€”OCOR10, â€”OCO2R11, â€”CO2R10, OPO3R10; R10 represents H, alkyl, aryl, or aralkyl; R11 represents alkyl or aryl; the dotted line between carbon atoms 5 and 6 represents an optional double bond, such that when a double bond is present, A and B independently represent â€”R10, halo â€”OR11, â€”OCO2R11 or â€”OC(O)R10, and when no double bond is present between carbon atoms 5 and 6, A and B each independently represent H2, â€”(OR11)2; H and halo, dihalo, alkyl and H, (alkyl)2, â€”H and â€”OC(O)R10, and â€”OR10, &boxH;O, aryl and H, &boxH;NOR10 or â€”Oâ€”(CH2)pâ€”Oâ€” wherein p is 2, 3 or 4; W represents â€”SR70; and R70 represents aryl.