Patent ID: 9068019
Filing Date: 2015-06-30
Classification: A61P,C07K

Abstract:
1. A modified human tumor necrosis factor receptor-1 polypeptide, comprising an amino acid sequence selected from the group consisting of: an amino acid sequence having one or more amino acid modifications selected from the group consisting of L150I, K161Q, K161N, D207N, L68V/K161Q, L68V/K161N and L68V/D207N in the amino acid sequence consisting of amino acid residues 41-211 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO: 1; an amino acid sequence having one or more amino acid modifications selected from the group consisting of L68V, R133Q, W136S, F141I and F141V in the amino acid sequence consisting of amino acid residues 41-166 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO: 1; and an amino acid sequence having one or more amino acid modifications selected from the group consisting of positions L68I, L68V, E85N, R106H, R128H, R133Q, Y135I, W136S, F141I and F141V in the amino acid sequence consisting of amino acid residues 41-148 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO: 1.