Patent ID: 6441144
Filing Date: 2002-08-27
Classification: C07K

Abstract:
A process for preparing an intravenously administrable &ggr;-globulin solution which comprises:(a) subjecting an impure &ggr;-globulin solution to polyethylene glycol fractionation for obtaining a purified &ggr;-globulin; (b) treating the polyethylene glycol purified solution of &ggr;-globulin with an organic solvent for inactivating envelope viruses; (c) heat treating the polyethylene glycol purified solution of &ggr;-globulin under time and temperature conditions sufficient for inactivating heat sensitive viruses; and then (d) removing aggregates generated by the heat treatment; wherein heat treatment step (c) is carried out on the &ggr;-globulin-organic solvent solution resulting from step (b) without any intervening processing.