Patent ID: 6063782
Filing Date: 2000-05-16
Classification: A61P,C07D

Abstract:
Pyrrolopyridazine derivatives having a general formula: ##STR7## or pharmacologically acceptable salts thereof, wherein R.sup.1 represents a C.sub.2 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.4 alkenyl group substituted with fluorine, chorine or bromine, a C.sub.6 aryl-C.sub.3 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.4 alkynyl group, a cyclopropyl group, a C.sub.3 -C.sub.6 cycloalkylmethyl group said cycloalkylmethyl group being unsubstituted or substituted by at least one C.sub.1 -C.sub.4 alkyl group or a halogeno-C.sub.1 -C.sub.4 alkyl group, a (C.sub.5 -C.sub.7 cycloalkyl)-C.sub.1 -C.sub.6 alkyl group;R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a C.sub.6 aryl group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group;R.sup.5 represents a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, halogeno-C.sub.1 -C.sub.4 alkyl or halogeno-C.sub.1 -C.sub.4 alkoxy, a naphthyl group, a furyl group, a thienyl group, an oxazolyl group, a benzoxazolyl group, a thiazolyl group, a benzothiazolyl group, an imidazolyl group, a benzoimidazolyl group, a 1,3,4-oxadiazolyl group, a 1,3,4-thiadiazolyl group, a pyridyl group, a pyrazinyl group or a pyridazinyl group;A represents a methylene group;X represents an oxygen atom, a sulfur atom or a methylene group; andwhen n is 1, m is 0.