Patent ID: 7094537
Filing Date: 2006-08-22
Classification: B01J,B82Y,C40B

Abstract:
1. A micro array for binding a target, comprising: (a) a substrate surface; (b) at least one feature of unstructured probes attached to said substrate surface for binding to said substrate surface for binding to said target and providing a first signal; (c) nucleic acid structured probes attached to at least a portion of an interfeature area of said substrate surface in a manner that prevents binding of said target to said interfeature areas of said substrate surface, wherein said structured probes are selected from the group consisting a pseudo knot, stem-loops, bulges, hairpin, t RNA, triplex, and quadriplex and provide a second signal, and (d) a light source for providing excitation of said unstructured and structured probes wherein said at least one feature of unstructured probes provides said first signal and said structured probes provides said second signal and wherein said first signal produced by said at least one feature of unstructured probes can be compared to said second signal produced by said structured probes.