Patent ID: 7718682
Filing Date: 2010-05-18
Classification: A61P,C07D

Abstract:
1. A method of inhibiting the activity of TNF-alpha, IL-1, IL-6, or COX-2, comprising: administering to a subject a therapeutically effective amount of a compound represented by formula 1: in a physiologically acceptable carrier; wherein Z is: n, m, q and r independently represent integers from zero to 4 provided that n+m≦4 and q+r≦4; p and s are independently integers from zero to 5 provided that p+s≦5; a and b are double bonds which may be present or absent; when present, the double bonds may be in the E or Z configuration and, when absent, the resulting stereocenters may have the R- or S-configuration; R and R′ independently represent hydrogen; C R″ independently represents hydrogen; C A, A′ and A″ independently represent hydrogen; C B, B′ and B″ independently represent hydrogen; C X, X′ independently represent