Patent ID: 6710078
Filing Date: 2004-03-23
Classification: C07D

Abstract:
A compound of Formula (I) wherein:R1 is alkyl of 1 to 10 carbon atoms optionally substituted with 1 to 4 substituents independently selected from the group consisting of alkyl of 1 to 10 carbon atoms, â€”OH, â€”SH, â€”NH, and holgen, alkenyl of 2 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms, optionally substituted aryl of 6 to 12 carbon atoms, and optionally substituted heteroaryl; R2 is phenyl, substituted phenyl (having from 1 to 3 substituents each independently selected from the group consisting of halogen, alkyl of 1 to 10 carbon atoms, alkylthio of 1 to 10 carbon atoms, alkylamino of 1 to 10 carbon atoms, amino, carboxy, alkylsulfonyl of 1 to 10 carbon atoms, cyano, nitro, perfluoroalkyl of 1 to 10 carbon atoms, and alkoxy of 1 to 10 carbon atoms) or naphthyl; R3 is optionally substituted aryl and optionally substituted heteroaryl; X is â€”Oâ€”, â€”Sâ€”, or â€”NH; Y is â€”OH, â€”SH4, â€”NH2, â€”NHR5, â€”CO2H, â€”CONHOH, halogen, or heteroaryl; R4 is hydrogen, alkyl of 1 to 10 carbon atoms, aryl of 6 to 12 carbon atoms, and aralkyl of 7 to 13 carbon atoms; R5 is alkyl of 1 to 10 carbond atoms, aryl of 6 to 12 carbon atoms, and aralkyl of 7 to 13 carbon atoms; Z is H or methyl; Q is an alkyl chain of 2 to 6 carbon atoms optionally substituted with 1 to 4 substituents independently selected from the group consisting of alkyl of 1 to 10 carbon atoms, â€”OH, â€”SH, â€”NH, halogen and alkenyl of 2 to 6 carbon atoms; or a pharmacologically acceptable salt thereof.