Patent ID: 6232324
Filing Date: 2001-05-15
Classification: A61K,A61P,C07D

Abstract:
A method of preventing or treating dialysis-induced hypotension and/or hypotension subsequent to dialysis, comprising:administering to a subject a therapeutically effective amount of a pyrazolopyridine compound represented by the formula (I): ##STR4##whereinR.sup.1 is(1) lower alkyl,(2) aryl,(3) aryl substituted by at least one substituent selected from the group consisting of halogen, lower alkoxy, nitro, amino and protected amino,(4) an unsaturated heterocyclic group selected from the group consisting of pyrrolyl, pyrrolinyl, imidazolyl, pyridyl, pyridyl N-oxide, dihydropyridyl, tetrahydropyridyl, pyridazinyl, furyl, and thienyl,(5) an unsaturated heterocyclic group selected from the group consisting of pyrrolyl, pyrrolinyl, imidazolyl, pyridyl, pyridyl N-oxide, dihydropyridyl, tetrahydropyridyl, pyridazinyl, furyl, and thienyl, which is substituted with at least one substituent selected from the group consisting of lower alkyl, hydroxy(lower)alkyl, (lower)alkoxy(lower)alkyl, acyloxy(lower)alkyl, lower alkoxycarbonyl, carboxy, acyl(lower)alkyl, carboxy(1ower)alkyl, protected carboxy(lower)alkyl;(6) a saturated heterocyclic group selected from the group consisting of pyrrolidinyl and piperidino, or(7) an saturated heterocyclic group selected from the group consisting of pyrrolidinyl and piperidino, which is substituted with at least one substituent selected from the group consisting of lower alkyl, hydroxy(lower)alkyl, (lower)alkoxy(lower)alkyl, acyloxy(lower)alkyl, lower alkoxycarbonyl, carboxy, acyl(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkenyl, amino, di(lower)alkylamino, lower alkoxy, oxo, hydroxy, cyano, acyl, carboxy or protected carboxy;R.sup.2 is(1) a group of the formula: ##STR5##wherein R.sup.4 is protected amino or hydroxy and R.sup.5 is hydrogen or lower alkyl,(2) cyano, or(3) a group of the formula:A--R.sup.6wherein R.sup.6 is an acyl group, carboxy or protected carboxy, and A is a lower aliphatic hydrocarbon group optionally substituted with at least one substituent selected from the group consisting of hydroxy, halogen, lower alkoxy and acyl,(4) amidated carboxy,(5) an unsaturated heterocyclic group selected from the group consisting of pyrrolyl, pyrrolinyl, imidazolyl, pyridyl, pyridyl N-oxide, dihydropyridyl, tetrahydropyridyl, pyridazinyl, dihydropyridazinyl, tetrahydropyridazinyl, pyrimidyl, dihydropyrimidinyl, pyrazolyl, imidazothiadiazolyl, furyl, and thienyl, optionally substituted with at least one substituent selected from the group consisting of lower alkyl, caboxy(lower)alkyl, carboxy(lower)alkenyl, amino, di(lower)alkylamino, halogen, lower alkoxy, oxo, hydroxy, cyano and acyl,(6) amino, or(7) protected amino; andR.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;or a salt thereof.