Patent ID: 8697396
Filing Date: 2014-04-15
Classification: A61P,C07K

Abstract:
1. A method of producing a polypeptide having increased binding affinity for C1q, wherein said polypeptide comprises an Fc region and said Fc region comprises a hinge region, said method comprising introducing an amino acid substitution into the hinge region selected from the group consisting of: (a) C233D (not EU number, Kabat number); (b) C233D (not EU number, Kabat number) and D234C (not EU number, Kabat number); (c) K222W and T223W; (d) C233D (not EU number, Kabat number), D234C (not EU number, Kabat number), K222W and T223W; (e) K222W, T223W and H224W; and (f) D234W (not EU number, Kabat number) and K222W, utilizing the EU index numbering system set forth in Kabat except where indicated.