Patent ID: 6048896
Filing Date: 2000-04-11
Classification: A61P,C07C

Abstract:
Method for treatment of a neurodegenerative disease by inhibiting the enzyme kynurenine-3-hydroxylase, comprising: administering to a patient in need thereof an effective amount of a compound of formula (I) either as a single isomer or as a mixture of isomers ##STR7## wherein X, Y and Z are, each independently, hydrogen; halogen; nitro; C.sub.1 -C.sub.6 alkyl; phenyl; benzyl; C.sub.1 -C.sub.6 alkoxy; C.sub.1 -C.sub.6 alkylthio; SOR.sub.5, SO.sub.2 R.sub.5 in which R.sub.5 is C.sub.1 -C.sub.6 alkyl, phenyl, benzyl, C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl; SO.sub.2 N(R.sub.6).sub.2 in which each of R.sub.6 is, independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, phenyl or benzyl;R is hydroxy; --OR.sub.5 in which R.sub.5 is as defined above; --N(R.sub.6).sub.2 or --N(R.sub.6)OR.sub.6 in which R.sub.6 is as defined above;R.sub.1 and R.sub.2 are, each independently, hydrogen, halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof.