Patent ID: 6512123
Filing Date: 2003-01-28
Classification: A61P,C07C,C07D

Abstract:
At least one compound selected from a compound of formula I whereinA denotes a bond, or is selected from â€”CH2â€”Oâ€”, â€”CH2â€”Sâ€”, â€”CH2â€”CH2â€”, and â€”NHâ€”COâ€”; X denotes the group â€”NR3â€”, &boxH;CO, or â€”CH(OH1)â€”; Y denotes an oxygen atom, a sulfur atom, or the group â€”NR4â€”; Z denotes a straight chain alkylene group selected from 4, 5, 6, 7, and 8 carbon atoms, wherein one CH2 group may be replaced by an oxygen or a sulfur atom, or wherein 2 carbon atoms form a C&boxH;C double bond, and which is optionally substituted by one or two substituents selected from (1-4C)alkyl and halogen atoms; R1 and R2 denote substituents independently selected from a hydrogen atom, halogen atoms, (1-4C)alkyl, trifluoromethyl, hydroxy, (1-4C)alkoxy, benzyloxy, (1-3C)alkylenedioxy, nitro, amino, (1-4C)alkylamino, di[(1-4C)alkyl]-amino, and (1-4C)alkanoylamino groups; R3 and R4 independently denote hydrogen atoms or (1-4C)alkyl groups; and its enantiomers, diastereoisomers, racemates, pharmaceutically acceptable salts and mixtures thereof.