Patent ID: 8415474
Filing Date: 2013-04-09
Classification: C07D

Abstract:
1. A one-pot process for the preparation of a compound having Formula (IV) from a mixture of compounds having Formulas (II) and (II′), the process comprising: (a) contacting the compounds having Formulas (II) and (II′) with an asymmetric catalyst and a hydrogen donor comprising a formate ion to form a mixture of compounds having Formulas (III) and (III′); and (b) contacting the compounds having Formulas (III) and (III′) with an alkali metal and an electron source to form the compound having Formula (IV) according to the following reaction scheme: wherein: R R R R R R R R and further wherein the compounds haying Formulas (III) and (III′) are not crystallized prior to step (b).