Patent ID: 8486640
Filing Date: 2013-07-16
Classification: G01N

Abstract:
1. A method of diagnosing susceptibility to acute pouchitis after ileal pouch anal anastomosis for ulcerative colitis in an individual, comprising: obtaining a sample from the individual; assaying the sample to determine the presence or absence of positive antibody expression of pANCA and Cbir1 in the individual; assaying the sample to determine the presence or absence of a low immune reactivity of pANCA, wherein a low immune reactivity is less than 100 EU/ml in a serum sample taken from the individual; and diagnosing susceptibility to acute pouchitis after ileal pouch anal anastomosis for ulcerative colitis in an individual based upon the presence of a positive antibody expression of pANCA and Cbir1 and the presence of a low immune reactivity of pANCA.