Patent ID: 6017926
Filing Date: 2000-01-25
Classification: A61K,C07D

Abstract:
A compound having a structural formula selected from the group consisting of ##STR40## wherein the dotted line a represents a single or a double bond, provided that when a represents a double bond, the double bond carbon atoms are substituted only with R.sup.10 and R.sup.12 ;X is selected from the group consisting of ##STR41## a 5- or 6-membered monocyclic aromatic or nonaromatic ring system having 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, O, and S wherein the ring nitrogen atoms are unsubstituted or substituted with one R.sup.1 substituent and the ring carbon atoms are unsubstituted or substituted with one or two R.sup.1 substituents, anda 9- to 14-membered polycyclic ring system, wherein one or more of the rings is aromatic, and wherein the polycyclic ring system has 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, O, and S wherein the ring nitrogen atoms are unsubstituted or substituted with one R.sup.1 substituent and the ring carbon atoms are unsubstituted or substituted with one or two R.sup.1 substituents;Y is selected from the group consisting of--(CH.sub.2).sub.m --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO.sub.2 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --, and--(CH.sub.2).sub.m --Z--(CH.sub.2).sub.n --,wherein Z is a 3- to 10-membered monocyclic or polycyclic aromatic or nonaromatic ring system having 0, 1, 2, 3, or 4 heteroatoms selected from the group consisting of N, O, and S wherein the ring nitrogen atoms are unsubstituted or substituted with one R.sup.1 substituent and the ring carbon atoms are unsubstituted or substituted with one or two R.sup.1 substituents, andwherein any methylene (CH.sub.2) carbon atom in Y, other than in R.sup.4, can be substituted by one or two R.sup.3 substituents; andwherein R.sup.1 and R.sup.2 are each independently selected from the group consisting ofhydrogen, halogen, C.sub.1-10 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloheteroalkyl, C.sub.3-8 cycloalkyl C.sub.1-6 alkyl, C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl, aryl, aryl C.sub.1-8 alkyl, amino, amino C.sub.1-8 alkyl, C.sub.1-3 acylamino, C.sub.1-3 acylamino C.sub.1-8 alkyl, (C.sub.1-6 alkyl).sub.p amino, (C.sub.1-6 alkyl).sub.p amino C.sub.1-8 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy C.sub.1-6 alkyl, hydroxycarbonyl, hydroxycarbonyl C.sub.1-6 alkyl, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkoxycarbonyl C.sub.1-6 alkyl, hydroxycarbonyl-C.sub.1-6 alkyloxy, hydroxy, hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkyloxy-C.sub.1-6 alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, trifluoroethoxy, C.sub.1-8 alkyl-S(O).sub.p, (C.sub.1-8 alkyl).sub.p aminocarbonyl, C.sub.1-8 alkyloxycarbonylamino, (C.sub.1-8 alkyl).sub.p aminocarbonyloxy, (aryl C.sub.1-8 alkyl).sub.p amino, (aryl).sub.p amino, aryl C.sub.1-8 alkylsulfonylamino, and C.sub.1-8 alkylsulfonylamino;or two R.sup.1 substituents, when on the same carbon atom, are taken together with the carbon atom to which they are attached to form a carbonyl group;each R.sup.3 is independently selected from the group consisting ofhydrogen,aryl,C.sub.1-10 alkyl,aryl--(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r S(O).sub.p --(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,oxo,trifluoromethyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--C.tbd.C--(CH.sub.2).sub.t --,aryl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--CH.dbd.CH--(CH.sub.2).sub.t --,aryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl, and(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl;or two R.sup.3 substituents, when on the same carbon atom, are taken together with the carbon atom to which they are attached to form a carbonyl group or a cyclopropyl group,wherein any of the alkyl groups of R.sup.3 are either unsubstituted or substituted with one to three R.sup.1 substituents, provided that each R.sup.3 is selected such that in the resultant compound the carbon atom or atoms to which R.sup.3 is attached is itself attached to no more than one heteroatom;each R.sup.4 is independently selected from the group consisting ofhydrogen,aryl,aminocarbonyl,C.sub.3-8 cycloalkyl,amino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl,(aryl C.sub.1-5 alkyl).sub.p aminocarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,C.sub.1-8 alkyl,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.2-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.2-6 alkyl,C.sub.1-8 alkylsulfonyl,C.sub.1-8 alkoxycarbonyl,aryloxycarbonyl,aryl C.sub.1-8 alkoxycarbonyl,C.sub.1-8 alkylcarbonyl,arylcarbonyl,aryl C.sub.1-6 alkylcarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,aminosulfonyl,C.sub.1-8 alkylaminosulfonyl,(aryl).sub.p aminosulfonyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonyl,arylsulfonyl,arylC.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylthiocarbonyl,arylthiocarbonyl, andaryl C.sub.1-6 alkylthiocarbonyl,wherein any of the alkyl groups of R.sup.4 are either unsubstituted or substituted with one to three R.sup.1 substituents;R.sup.5 and R.sup.6 are each independently selected from the group consisting ofhydrogen,C.sub.1-10 alkyl,aryl,aryl--(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r S(O).sub.p --(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--C.tbd.C--(CH.sub.2).sub.t --,aryl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--CH.dbd.CH--(CH.sub.2).sub.t --,aryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl, and(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl;or R.sup.5 and R.sup.6 are taken together with the carbon atom to which they are attached to form a carbonyl group,wherein any of the alkyl groups of R.sup.5 or R.sup.6 are either unsubstituted or substituted with one to three R.sup.1 substituents,and provided that each R.sup.5 and R.sup.6 are selected such that in the resultant compound the carbon atom to which R.sup.5 and R.sup.6 are attached is itself attached to no more than one heteroatom;R.sup.7 and R.sup.8 are each independently selected from the group consisting ofhydrogen,C.sub.1-10 alkyl,aryl,aryl--(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r S(O).sub.p --(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.2 --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--C.tbd.C--(CH.sub.2).sub.t --,aryl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--CH.dbd.CH--(CH.sub.2).sub.t --,aryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylcarbonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,arylaminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl, andC.sub.7-20 polycyclyl C.sub.0-8 alkylsulfonylamino;wherein any of the alkyl groups of R.sup.7 and R.sup.8 are either unsubstituted or substituted with one to three R.sup.1 substituents,and provided that each R.sup.7 and R.sup.8 are selected such that in the resultant compound the carbon atom to which R.sup.7 and R.sup.8 are attached is itself attached to no more than one heteroatom;R.sup.9 is selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,aryl,aryl C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,aryl C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,C.sub.1-8 alkylaminocarbonylmethylene, andC.sub.1-8 dialkylaminocarbonylmethylene;R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are each independently selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,aryl,halogen,hydroxyl,aminocarbonyl,C.sub.3-8 cycloalkyl,amino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl,hydroxycarbonyl,(aryl C.sub.1-5 alkyl).sub.p aminocarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.2-6 alkyl,C.sub.1-8 alkylsulfonyl,C.sub.1-8 alkoxycarbonyl,aryloxycarbonyl,aryl C.sub.1-8 alkoxycarbonyl,C.sub.1-8 alkylcarbonyl,arylcarbonyl,aryl C.sub.1-6 alkylcarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,aminosulfonyl,C.sub.1-8 alkylaminosulfonyl,(aryl).sub.p aminosulfonyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonyl,C.sub.1-6 alkylsulfonyl,arylsulfonyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylthiocarbonyl,arylthiocarbonyl,aryl C.sub.1-6 alkylthiocarbonyl,aryl--(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r S(O).sub.p --(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl--(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--C.tbd.C--(CH.sub.2).sub.t --,aryl--C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl--CH.dbd.CH--(CH.sub.2).sub.t --,aryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl--SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p amino,aminocarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl, and(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl; orR.sup.10 and R.sup.12 are taken together with the carbon atoms to which they are attached to form a 5- to 7-membered monocyclic aromatic or nonaromatic ring system having 0, 1, 2, 3, or 4 heteroatoms selected from the group consisting of N, O, and S wherein the ring nitrogen atoms are unsubstituted or substituted with one R.sup.1 substituent and the ring carbon atoms are unsubstituted or substituted with one or two R.sup.1 substituents,and wherein any of the alkyl groups of R.sup.10, R.sup.11, R.sup.12, and R.sup.13 are either unsubstituted or substituted with one to three R.sup.1 substituents;whereineach m is independently an integer from 0 to 6;each n is independently an integer from 0 to 6each p is independently an integer from 0 to 2;each r is independently an integer from 1 to 3;each s is independently an integer from 0 to 3;each t is independently an integer from 0 to 3; andeach v is independently an integer from 0 to 2;and the pharmaceutically acceptable salts thereof.