Patent ID: 6225460
Filing Date: 2001-05-01
Classification: C07F,C07H

Abstract:
A compound included for antiviral use having the formula Id ##STR48##wherein L.sup.1 is of the formula III ##STR49##wherein L.sup.2 is OR, SR or independently is L.sup.1 ;wherein n and n1 are 1;R is N-ethylmorpholino, pivaloyloxymethyl, phenyl, benzyl, isopropyl, t-butyl, ethyl, isopropyl, butyl, adamantoyloxymethyl, 3-methoxyphenyl, 2-carboethoxyphenyl, 4-fluorophenyl, 2,4-difluorophenyl, 3,5-dimethoxyphenyl, 2,4-dichlorophenyl, 2-ethoxyphenyl, 3-dimethylaminophenyl, 4-trifluoromethylbenzyl, 2-ethylsalicyl, --O--CH.sub.2 --O--C(O)--C.sub.10 H.sub.15, --C.sub.6 H.sub.4 --CH.sub.2 --N(CH.sub.3).sub.2, --CH.sub.2 --CH.sub.2 F, --CH.sub.2 --CH.sub.2 Cl, --CH.sub.2 --CF.sub.3, --CH.sub.2 --CCl.sub.3, R.sup.5, NHR.sup.6 or N(R.sup.6).sub.2 ;wherein,R.sup.5 is CH.sub.2 C(O)N(R.sup.6).sub.2, CH.sub.2 C(O)OR.sup.6, CH.sub.2 OC(O)R.sup.6, CH(R.sup.6)OC(O)R.sup.6, CH.sub.2 C(R.sup.6).sub.2 CH.sub.2 OH, or CH.sub.2 OR.sup.6, andR.sup.6 is C.sub.1 -C.sub.20 alkyl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms), C.sub.6 -C.sub.20 aryl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms) or C.sub.7 -C.sub.20 aryl-alkyl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms);R.sup.1 is H, methyl, ethyl, isopropyl, phenyl or benzyl;R.sup.2 is H;R.sup.3 is H, --CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 --CH(CH.sub.3).sub.2, --CHCH.sub.3 --CH.sub.2 --CH.sub.3, --CH.sub.2 --CH.sub.6 H.sub.5, --CH.sub.2 CH.sub.2 --S--CH.sub.3, --CH.sub.2 OH, --CH(OH)--CH.sub.3, --CH.sub.2 --SH, --CH.sub.2 --C.sub.6 H.sub.4 OH, --CH.sub.2 --CO--NH.sub.2, --CH.sub.2 --CH.sub.2 --CO--NH.sub.2, --CH.sub.2 --COOH, --CH.sub.2 --CH.sub.2 --COOH, --(CH.sub.2).sub.4 --NH.sub.2, --(CH.sub.2).sub.3 --NH--C(NH.sub.2)--NH.sub.2, 1-guanidinoprop-3-yl, benzyl, 4-hydroxybenzyl, imidazol-4-yl, indol-3-yl, methoxyphenyl or ethoxyphenyl;R.sup.4 is methyl, ethyl, propyl, isopropyl, butyl, t-butyl, phenyl, benzyl, 1-pyridyl, 3-pyridyl, 1-pyrimidinyl, pivaloyloxymethyl, N-ethylmorpholino, N-2-propylmorpholino, methoxyethyl, 4-N-methylpiperidyl, 3-N-methylpiperidyl, 1-ethylpiperazinyl 2-, 3-, and 4-N,N-dimethylaminophenyl or 2-, 3-, or 4-N,N-diethylaminophenyl;Z is --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O--CH.sub.2 --CH(CH.sub.2 OH)--, --CH.sub.2 --O--CH.sub.2 --CH(CH.sub.2 F)--, --CH.sub.2 --O--CH.sub.2 --CH(CH.sub.3)--, --CH.sub.2 --O--CH.sub.2 --CH(CH.dbd.CH.sub.2)-- or --CH.sub.2 --O--CH.sub.2 --CH(CH.sub.2 N.sub.3)--, or is of formula IV or V ##STR50##whereinR.sup.25 and R.sup.29 are O;R.sup.26 is CH;R.sup.27 and R.sup.28 are H; andB is adenin-9-yl, 1-deazaadenin-9-yl, 3-deazaadenin-9-yl, 7-deaza-8-azaadenin-9-yl, 8-azaadenin-9-yl, guanin-9-yl, 2,6-diaminopurin-9-yl, 2-aminopurin-9-yl, thymin-1-yl, cytosin-1-yl, 5-fluorocytosin-1-yl, 6-azacytosin-1-yl, 5-methylcytosin-1-yl, 5-bromovinyluracil-1-yl, 5-fluorouracil-1-yl or 5-trifluoromethyluracil-1-yl.