Patent ID: 9145451
Filing Date: 2015-09-29
Classification: A61K,A61P,C07K

Abstract:
1. A compound comprising the structure Q-L-Y; wherein Q is a glucagon superfamily peptide having agonist activity at the glucagon receptor, the GIP receptor, the GLP-1 receptor, or a combination thereof; Y is a G protein-coupled receptor (GPCR) ligand which activates a G protein-coupled receptor selected from an adrenergic receptor or a nicotinic acetylcholine receptor with an EC L is a linking group or a bond, wherein Q comprises an amino acid sequence at least 50% identical to native glucagon that retains the alpha-helix conformation of the amino acids corresponding to amino acids 12-29 of native glucagon (SEQ ID NO: 1601) or an amino acid sequence at least 50% identical to native GLP-1 that retains the alpha-helix conformation of the amino acids corresponding to amino acids 12-29 of native GLP-1 (SEQ ID NO: 1603); wherein L-Y is conjugated to Q at position 10, 20, 24, 30, 37, 38, 39, 40, 41, 32, or 43 of Q.