Patent ID: 6384218
Filing Date: 2002-05-07
Classification: A61P,C07D

Abstract:
A 3,5-dioxa-12-azawurtzitane compound represented by the following formula (I): wherein R3 represents an alkyl group, R2 is selected from the group consisting of hydrogen, the following members:CH3â€”(CH3)2CHâ€”(CH3)2CHCH2â€”CH3CH2CH(CH3)â€”PhCH2â€”HOPhCH2â€”â€ƒHOCH2â€”CH3CH(OH)â€”HSCH2â€”COOHCH(NH2)CH2Sâ€”SCH2â€”CH3S(CH2)2â€”COOHCH2â€”HOOC(CH2)2â€”NH2CH2(CH2)3â€”NH2NHC(NM(CH2)3â€”and said members substituted with one or more of alkyl, acetyl, alkoxy, benzoxycarbonyl, tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, and 1,7,9-trialkyl-3,5-dioxa-12H-azawurtzitan-12-yl, and R3 is selected from the group consisting of hydroxyl, oligopeptides, polypeptides and polyamino acids, provided that where R3 is an oligopeptide, polypeptide or polyamino acid it is linked through a terminal amino group.