Patent ID: 8673592
Filing Date: 2014-03-18
Classification: A61P,C07K,G01N

Abstract:
1. A hybridoma which produces a monoclonal antibody, or antigen-binding fragment thereof, which binds to an extracellular region of a human system ASC amino acid transporter 2 (ASCT2) in its native conformation, wherein said human ASCT2 consists of the amino acid sequence of SEQ ID NO: 2, wherein said antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) domain and a light chain variable region (VL) domain, and wherein said antibody or antigen-binding fragment thereof comprises a variable region selected from the group consisting of: a VH domain comprising the amino acid sequence of SEQ ID NO: 76; a VH domain comprising the amino acid sequence of SEQ ID NO: 82; and a VL domain comprising the amino acid sequence of SEQ ID NO: 84.