Patent ID: 6503930
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A compound or a pharmaceutically-acceptable salt or tautomer thereof, wherein:the compound corresponds in structure to Formula III: R1 is selected from the group consisting of hydrido, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, cycloalkylalkylene, cycloalkenylalkylene, haloalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, aralkyl, aralkenyl, aralkynyl, heterocyclylalkylene, alkoxyalkyl, aryloxyalkyl, heterocyclyloxyalkyl, mercaptoalkyl, mercaptoaryl, mercaptoheterocyclyl, alkylthioalkylene, arylthioalkylene, amino, alkylamino, arylamino, aminoaryl, alkylaminoalkylene, and heterocyclylalkylene; and X1 is selected from the group consisting of hydrido, halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, alkoxy, alkenoxy, alkynoxy, aryloxy, heterocyclyloxy, aralkoxy, alkylthio, arylthio, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, heterocyclylamino, aminoalkyl, aminocarbonyl, cyano, hydroxyl, hydroxyalkyl, alkoxycarbonyl, aryloxycarbonyl, heterocyclyloxycarbonyl, formyl, nitro, nitroalkyl, alkylcarbonylamino, arylcarbonylamino, haloalkylsulfinyl, haloalkylsulfonyl, alkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, and haloalkyl; and R4 is selected from the group consisting of hydrido, alkyl, aryl, haloalkyl, heterocyclyl, cycloalkyl, alkenyl, cycloalkenyl, alkoxy, alkylthio, arylthio, carboxy, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkylene, heterocyclylalkyl, amino, alkylamino, alkynylamino, arylamino, heterocyclylamino, heterocyclylalkylamino, heterocyclylaminoalkyl, and aminoheterocycylamino, wherein: the aryl, heterocyclyl, cycloalkyl, or cycloalkenyl is optionally substituted with one or more radicals independently selected from the group consisting of halo, amino, alkyl, alkenyl, alkynyl, alkoxy, aryloxy, aralkoxy, haloalkyl, ethynylamino, propargylamino, and alkylamino, and the amino nitrogen of the heterocyclylalkylamino or heterocyclylaminoalkyl is optionally substituted with one or more independently selected alkyl; and R5 is selected from the group consisting of hydrido and alkyl; and R6 is selected from the group consisting of hydrido, alkyl, alkenyl, and alkynyl.