Patent ID: 7638616
Filing Date: 2009-12-29
Classification: A61K,C12N,C12P,C12Q,C12Y

Abstract:
1. An isolated nucleic acid comprising a nucleotide sequence encoding a variant of a parent beta-glucosidase, wherein the variant comprises a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2, or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity, the parent beta-glucosidase comprises an amino acid sequence which has at least 95% identity to amino acids 1 to 842 of SEQ ID NO: 2 or amino acids 1 to 844 of SEQ ID NO: 70, and the variant having beta-glucosidase activity comprises an amino acid sequence which has at least 95% identity to amino acids 1 to 842 of SEQ ID NO: 2 or amino acids 1 to 844 of SEQ ID NO: 70.