Patent ID: 6043342
Filing Date: 2000-03-28
Classification: A61K,C07K,C12Q,G01N

Abstract:
A human PDZK1 protein whose presence indicates an ongoing neoplastic development within cells and tissues of epithelial cell origin, said PDZK1 protein comprisinga polypeptide(i) having a molecular weight of about 63 kD as defined by SDS polyacrylamide gel electrophoresis;(ii) which is comprised of about 519 amino acids;(iii) having four distinct PDZ domains as part of its overall structure, each of said PDZ domains varying in size from 54-80 amino acids;(iv) which is devoid of a SH3 binding domain;(v) which does not contain a guanylate kinase domain; and(vi) which interacts with the membrane associated protein MAP17.