Patent ID: 6380199
Filing Date: 2002-04-30
Classification: A61K,A61P

Abstract:
A method of treating ADHD comprising administering a 5-HT6 receptor antagonist of formula (A) hereinbelow to a subject having ADHD: wherein:P is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; A is a single bond, a C1-6alkylene or a C1-6alkenylene group; R1 is halogen, C1-6alkyl optionally substituted by one or more halogen atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, hydroxy, C1-6alkyl substituted with hydroxy, C1-6alkoxy substituted with hydroxy, C1-6alkyloxy substituted with C1-6alkoxy, C1-6alkanoyl, nitro, amino, C1-6alkylamino or diC1-6alkylamino, cyano or R1 is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; n is 0, 1, 2, 3, 4, 5 or 6, R2 is hydrogen, C1-6 alkyl or aryl C1-6 alkyl; R3 is a group R5 or together with R5 forms a group (CH2)2O or (CH2)3O or R3 is linked to R2 to form a group (CH2)2 or (CH2)3; R4 is â€”X(CH2)pâ€”R6 where X is a single bond, CH2, O, NH or Nâ€”C1-6 alkyl and p is 0 to 6 and R6 is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from nitrogen, sulphur or oxygen, or R6 is NR7R8 where R7 and R8 are independently hydrogen, C1-6 alkyl or arylC1-6alkyl; and R5 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, hydroxy, C1-6alkyl substituted with hydroxy, C1-6alkoxy substituted with hydroxy, C1-6alkyloxy substituted with C1-6alkoxy, C1-6alkanoyl, nitro, trifluoromethyl, cyano or aryl or a pharmaceutically acceptable salt thereof.