Patent ID: 6696482
Filing Date: 2004-02-24
Classification: A61K,A61P

Abstract:
A formulation comprising:(a) one or more hydrophobic pharmaceutical agents, wherein said agents are independently selected from the group consisting of quinazoline-, nitrothiazole-, and indolinone-based compounds; (b) one or more polyoxyhydrocarbyl compounds; (c) one or more polyglycolized lipids; and (d) one or more pharmaceutically acceptable surfactants; wherein said indolinone-based compound is an indolinone-based compound of formula VI: â€ƒat a concentration of about 0.1 to about 100 mg/ml; wherein R1, R2, R3, and R4 are selected from the group consisting of hydrogen, trihalomethyl, hydroxyl, thioether, cyano, alkoxy, alkyl, amino, bromo, fluoro, chloro, iodo, mercapto, thio, cyanoamido, alkylthio, aryl, heteroaryl, carboxyl, ester, oxo, alkoxycarbonyl, alkenyl, alkoxy, nitro, alkoxyl, and amido moieties; and R5 is an optionally substituted aryl or heteroaryl cyclic moiety; wherein at least one said polyoxyhydrocarbyl compounds is PEG-400 at a concentration of about 0.01 to about 10 g/ml and at least one of said pharmaceutically acceptable surfactants is ethoxylated castor oil at a concentration of about 0.01 to 10 g/ml.