Patent ID: 6017742
Filing Date: 2000-01-25
Classification: C07H,C08F,C12N,G01N,Y10S

Abstract:
An immobilized biologically active substance selected from the group consisting of an antibody, an antigen, a DNA, a synthetic DNA, an RNA and a synthetic RNA, which is reactive with a carbodiimide group, comprising said biologically active substance immobilized on a material comprising a carrier selected from the group consisting of a plastic, an inorganic polymer, a metal, a natural polymer and a ceramic, and a carbodiimide group-containing polymer supported on the carrier, said polymer containing 2 to 100 carbodiimide groups per molecule and having a molecular weight of 1,000-100,000 and being produced by carbodiimidization of an organic polyisocyanate selected from the group consisting of 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, 4,4'-dicyclohexylmethane diisocyanate, 4,4',4""-triphenylmethylene triisocyanate, xylene diisocyanate, m-tetramethylxylylene diisocyanate, hexamethylene-1,6-diisocyanate, lysine diisocyanate, hydrogenated methylene diphenyl diisocyanate, m-phenyl diisocyanate, naphthylene-1,5-diisocyanate, 4,4'-biphenylene diisocyanate, diphenylmethane-4,4'-diisocyanate, 3,3'dimethoxy-4,4'-biphenyl diisocyanate, 3,3'-dimethyldiphenylmethane-4,4'-diisocyanate, isophorone diisocyanate and mixtures thereof.