Patent ID: 6348468
Filing Date: 2002-02-19
Classification: A61P,C07D

Abstract:
A pyridazine compound having the formula (1): wherein:R1 is phenyl or pyridyl which is each unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen and lower alkoxy; R2 is phenyl which is unsubstituted or substituted at the 4-position thereof with lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and at the other positions by 1 or 2 substituents selected from the group consisting of halogen, lower alkoxyl, lower alkylthio, lower alkylsulfinyl and lower alkylsulfonyl; R3 is lower alkoxy, lower cycloalkyl; or phenyl, pyridyl or phenyloxy which is each unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, carboxy, lower alkoxycarbonyl, nitro, amino, lower alkylamino and lower alkylthio; piperidino, piperidyl, piperazino or morpholino, which is each unsubstituted or subsituted by 1 to 3 substituents selected from the group consisting of halogen and lower alkyl; aminocarbonyl which is unsubstituted or subsituted by benzyl, phenethyl, and 1 to 3 substituents selected from the group consisting of halogen and lower alkyl; or lower alkylcarbonyl; and A is a linear or branched lower alkylene group having 1 to 6 carbon atoms or linear or branched alkenylene having 2 to 9 carbon atoms; or a pharmaceutically acceptable salt thereof.