Patent ID: 8354546
Filing Date: 2013-01-15
Classification: C12P

Abstract:
1. A process for esterification and racemization of a 2(S)-(hydroxymethyl)-1,3-oxathiolane compound of Formula IIIa; or a 2(R)-(hydroxymethyl)-1,3-oxathiolane compound of Formula IIIb; comprising the steps of: (i) an esterification reaction of said compound of Formula IIIa or said compound of Formula IIIb with an esterification agent, so as to generate a 2(S)-(acyloxymethyl)-1,3-oxathiolane compound of Formula Ib or a 2(R)-(acyloxymethyl)-1,3-oxathiolane compound of Formula Ia where R 1 is a group selected from among hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl, cycloalkenyl, cycloalkenyl-alkyl, cycloalkyl, cycloalkyl-alkyl, heteroaryl, heteroaryl-alkyl, heterocycloalkyl, or heterocycloalkyl-alkyl and (ii) an acid-mediated racemization of said compound of Formula Ia or said compound of Formula Ib yielding a compound of Formula I of lower enantiomeric enrichment than said compound of Formula Ia or said compound of Formula Ib.