Patent ID: 7528160
Filing Date: 2009-05-05
Classification: A61P,C07D

Abstract:
1. A compound represented by the following Structural Formula: or a stereoisomer, pharmaceutically acceptable salt, or hydrate thereof, wherein: (a) T1 is a moiety of formula optionally substituted with (b) R1′, R26, R27, R28, R31, Z14′, and Z15′ are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (c) R2 is selected from the group consisting of C (d) X is selected from the group consisting of a bond, O, S, S(O) (e) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (f) Y is selected from the group consisting of C, O, S, NH and a single bond; (g) E is C(R3)(R4)A or A and wherein (h) Z5 is S or O; (i) Z12 is selected from the group consisting of hydrogen and -Z13C (j) Z13 is selected from the group consisting of a single bond, CO, CO (k) Z14 is selected from the group consisting of aryl and heteroaryl, wherein the aryl and heteroaryl is each optionally substituted with from one to three substituents independently selected from Z14′; (l) Z15 is selected from the group consisting of hydrogen, aryl, and heteroaryl, wherein the aryl and heteroaryl is each optionally substituted with from one to three substituents independently selected from Z15′; (m) R8 is selected from the group consisting of hydrogen, C (n) R9 is selected from the group consisting of hydrogen, C (o) R10, R11 are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (p) R12′, R12″, R13′, R14′, R15′, R16′, R17′, R18′, R19′, R20′, R21′, R22′, R23′, R24′, and R25′ are each independently selected from the group consisting of hydrogen, C (q) R30 is selected from the group consisting of C (r) R33 is selected from the group consisting of phenyl, thiophene, pyridine, piperidine,  wherein the phenyl, thiophene, pyridine, piperidine,  are each optionally substituted with R10 and R11;