Patent ID: 8119842
Filing Date: 2012-02-21
Classification: B01J,C07B,C07C

Abstract:
1. A method of producing a compound of formula k1 or k2 wherein: m is 0 or 1; n is from 0 to 3; Ar is: aryl; or heteroaryl, each of which may be optionally substituted with: halo; C Y is —O—; —S(O) R the method comprising: reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a catalyst of formula j1 or j2 wherein: D is an optionally chiral diamine; E and E′ are both halo, or E is hydrogen and E′ is BH L is a chiral diphosphine ligand; and Z is: halo or R