Patent ID: 7999068
Filing Date: 2011-08-16
Classification: C07K

Abstract:
1. A process for preparing a bicyclic glycopeptide compound of formula (I-A) wherein R 1 , R 2 and R 3 , equal or different from each other, can be hydrogen or an oxygen protecting group, selected from the group consisting of —COR 4 wherein R 4 is selected from the group consisting of a linear or branched C1-C4 alkyl group, phenyl and phenyl substituted with a halogen atom, benzyl or benzoyl, comprising the following steps: 1A) activation of the bicyclic peptide compounds of formula (I) with a suitable coupling agent selected from the group consisting of isobutyl chloroformate, a carbodiimide and a carbodiimide in combination with a hydroxy containing compound, phosphonium salts, N-oxide guanadine salts or uranium salts of to obtain a derivative of formula (II-A) wherein R is a member selected from group consisting of benzotriazole, azabenzotriazole, succinimidy and benzotriazole substituted with a halogen; 2A) reaction of the compound of formula (II-A) deriving from step 1A) in the presence of a solvent with the glycosidic derivative of formula (III-A) wherein R, R 1 , R 2 , R 3 are defined as above.