Patent ID: 6469029
Filing Date: 2002-10-22
Classification: A61K,A61P,C07K

Abstract:
A compound having Formula I: or pharmaceutically acceptable salts thereof; whereinQ is C6-14 aryl, C6-14 ar(C1-4)alkyl, C6-14 ar(C2-4)alkenyl, pyridyl, thienyl, indolyl, quinolinyl, benzothienyl, or imidazolyl; any of which can include one or more optional substituents independently selected from halo, trifluoromethyl, hydroxy, amino, nitro, cyano, C1-3 alkoxy, C1-3 alkyl, methylenedioxy, carboxyamino, C1-4 alkoxycarbonylamino, C6-10 aryloxycarbonylamino, C7-11aralkoxycarbonylamino, aminocarbonyl, mono- or di-(C1-4)alkylaminocarbonyl, acetamido, amidino, pyridyl, napthyl, pyrimidinyl, alkenyl, mono- or di-(C1-4)alkylamino, or combinations thereof; X is methylene, carbonyl, or sulfonyl; R1 is hydrogen or C1-3 alkyl; n is 2; m is 1-4; R2 is hydrogen or C1-3 alkyl; R3 is hydrogen or C1-3 alkyl; and R4, R5 and R6 are independently hydrogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, cyano or â€”CO2Rw, where Rw, in each instance, is one of C1-4alkyl, C4-7cycloalkyl, and benzyl, or Rw is one of where Rd, Rc and Rg are each hydrogen, Rf is methyl, and Rh is benzyl or tert-butyl.