Patent ID: 8778353
Filing Date: 2014-07-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A virus like particle (VLP) comprising an influenza matrix 1 (M1) protein, an influenza M2 protein, an influenza nucleoprotein (NP), an influenza polymerase complex protein, a first chimeric Type A influenza hemagluttinin (HA) protein and a chimeric first Type A influenza neuroamidase (NA) protein, wherein the first Type A influenza HA protein is a 1918 strain HA1 protein and the first Type A influenza NA protein is a 1918 strain NA1 protein, wherein the VLP lacks one or more of the proteins of an influenza polymerase complex, wherein the influenza proteins of the VLP are expressed from sequences encoding the proteins, and further wherein the expressed influenza proteins self-assemble into the VLP such that the influenza proteins are present in detectable amounts in the VLP and further wherein (i) a portion of the first influenza HA1 protein is replaced with a homologous region from a second Type A influenza HA protein, wherein the second influenza HA protein is from a different strain than the first influenza HA protein; and/or (ii) a portion of the first influenza NA1 protein is replaced with a homologous region from a second influenza NA protein, wherein the second influenza NA protein is from the same strain as the second HA protein.