Patent ID: 7902183
Filing Date: 2011-03-08
Classification: A61P,C07D

Abstract:
1. A compound of formula (1), wherein R R R R R R each R each R each R each R each R each R each R or a pharmacologically acceptable salt thereof, with the proviso that the following compounds are not included: 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N-(2-methoxy-ethyl)-N-methyl-benzamide, N-{1-[2-fluoro-4-(morpholino-4-carbonyl)-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N,N-dimethyl-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-ethyl-3-fluoro-N-methyl-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-ethyl-3-fluoro-N-(2-methoxy-ethyl)-benzamide, N-{1-[2-fluoro-4-([1.4]oxazepan-4-carbonyl)-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 4-(7-acetylamino-3-pyrazin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3,N,N-trimethyl-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-2-methoxy-N-(4-pyrrolidin-1-yl-cyclohexyl)-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-2-methoxy-N-methyl-N-(4-pyrrolidin-1-yl-cyclohexyl)-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-(1-cyclopentyl-piperidin-4-yl)-2-methoxy-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-(1-cyclopentyl-piperidin-4-yl)-2-methoxy-N-methyl-benzamide, N-(1-{4-[4-(cyclopentyl-methyl-amino)-piperidine-1-carbonyl]-3-methoxy-phenyl}-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl)-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N,N-diethyl-3-fluoro-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N-(2-methoxy-ethyl)-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N-(2-pyrrolidin-1-yl-ethyl)-benzamide, N-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-2-fluoro-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N-methyl-N-(1-methyl-piperidin-4-yl)-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-(2-dimethylamino-ethyl)-3-fluoro-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-(3-dimethylamino-propyl)-3-fluoro-N-methyl-benzamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N-(2-dimethylamino-ethyl)-3-fluoro-N-methyl-benzamide, N-{1-[2-fluoro-4-(4-isopropyl-piperazine-1-carbonyl)-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-N,N-diethyl-3-fluoro-benzamide, N-{1-[4-(4-cyclopentyl-piperazine-1-carbonyl)-2-fluoro-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, N-(1-{4-[4-(1-ethyl-propyl)-piperazine-1-carbonyl]-2-fluoro-phenyl}-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl)-acetamide, N-{1-[4-(4-sec-butyl-piperazine-1-carbonyl)-2-fluoro-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 2-{4-[4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-benzoyl]-piperazin-1-yl}-N,N-dimethyl-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N-(3-morpholin-4-yl-cyclobutyl)-benzamide, N-{1-[2-fluoro-4-(4-methyl-piperazine-1-carbonyl)-phenyl]-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl}-acetamide, 4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-N,N-dimethyl-benzamide, N-[4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluoro-phenyl]-2-dimethylamino-acetamide, N-[1-(4-acetylamino-2-fluoro-phenyl)-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl]-acetamide, 3-fluoro-4-[7-(3-methoxy-propionylamino)-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl]-N,N-dimethyl-benzamide and 3-fluoro-N,N-dimethyl-4-[7-(3-phenyl-propionylamino)-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl]benzamide.