Patent ID: 6290915
Filing Date: 2001-09-18
Classification: B01J,C40B

Abstract:
An apparatus for the synthesis and screening of chemical compounds, said apparatus comprising:a main fluid pathway including a plurality of reagent inputs, connected to a source of reagents and organic liquids for introducing reagents and organic liquids into the apparatus, and a solid support input, connected to a source of solid supports for introducing solid supports into the apparatus, each input being fluidly connectable to the main fluid pathway via a respective switchable input valve;a reaction chamber fluidly connectable to the main fluid pathway via a switchable reaction chamber valve downstream of the switchable input valves, the reaction chamber including an outlet downstream of a barrier arranged to prevent passage of said solid supports but allow passage of unbound molecules out of the reaction chamber; anda second fluid pathway, isolated from the main fluid pathway and including a screening agent input, connected to a source of screening agents for introducing screening agents in an aqueous medium into the apparatus, said second fluid pathway fluidly connectable to the reaction chamber via the switchable reaction chamber valve,said main fluid pathway for transporting said reagents and organic liquids and said solid supports to the reaction chamber for synthesis of chemical compounds in an organic medium, andsaid second fluid pathway for transporting said screening agents in an aqueous medium to said reaction chamber for screening of the synthesized chemical compounds.