Patent ID: 8492613
Filing Date: 2013-07-23
Classification: A61P,C12N,C12P

Abstract:
1. An isolated glycoprotein comprising a protein modified by at least one N-glycan, wherein the N-glycan comprises a motif selected from the group consisting of GN2XM3GN2, GN2FXM3GN2, GN3XM3GN2, and GN3FXM3GN2, in which GN is N-acetylglucosamine, X is β1,2-xylose, F is α1,3-fucose and M is mannose, wherein the glycoprotein is produced in a plant host system that expresses a recombinant UDP-N-acetylglucosamine:β-D mannoside β(1,4)-N-acetylglucosaminyltransferase (GnTIII), and wherein the at least one N-glycan is synthesized by at least the GnTIII.