Patent ID: 8956607
Filing Date: 2015-02-17
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A humanized or antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein the antibody or fragment thereof comprises a variable light chain comprising the amino acid sequences of CDR1, CDR2 and CDR3 of the murine antibody B-N10 variable light chain, and a variable heavy chain comprising the amino acid sequences of CDR1, CDR2 and CDR3 of the murine antibody B-N 10 variable heavy chain, wherein the variable heavy chain further comprises the residues Asn73 and Ser74 of SEQ ID NO:70 or comprise the residues Asn and Ser, respectively, in the heavy chain at the seventh and eighth positions C-terminal to the heavy chain CDR2 which contact IL-10 when said antibody binds to IL-10.