Patent ID: 6372912
Filing Date: 2002-04-16
Classification: C07C,C07D

Abstract:
A process for the hydrolytic ring cleavage of thiazolidine derivatives to give 2-aminomercaptan derivatives and carbonyl compounds, comprising:a) contacting an aqueous solution of a thiazolidine derivative with an acidic cation exchanger in the H+ form, giving a cleavage solution L1 containing the carbonyl compound and b) eluting the cation exchanger with a suitable eluent, to provide a solution L2 which contains the 2-aminomercaptan derivative wherein the thiazolidine derivatives used are compounds of the formula 1: whereA is CN, COOR4 or CONR5R6; R4 is CN, or a linear or branched C1- to C12-alkyl radical; R5 and R6 are identical or different and are H or a linear or branched C1- to C12-alkyl radical; R1 and R2 are identical or different and are H, a linear or branched C1- to C12-alkyl radical, a C1- to C6-alkyl radical which is mono- or polysubstituted by alkoxy or hydroxyl, (CH2)nCOOR4 where n is an integer from 0 to 12 and R4 is as defined above, a phenyl radical, or a phenyl, 1-naphthyl, 2-naphthyl, 9-phenanthrenyl, or 5- or 6-membered heteroaryl radical mono- or polysubstituted by C1- to C6-alkyl, said heteroaryl radical having 1 to 3 identical or different heteroatoms from the group consisting of O, N and S, or the radicals R1 and R2 together comprise a C2- to C9-cycloalkyl radical; and R3 is H or methyl.