Patent ID: 8987435
Filing Date: 2015-03-24
Classification: C07H,C12N

Abstract:
1. An oligomeric compound comprising a single-stranded oligonucleotide consisting of 10-30 linked nucleosides, wherein the oligonucleotide comprises a phosphate stabilizing nucleoside at the 5′-end, wherein the phosphate stabilizing nucleoside comprises: i) a 5′-terminal modified phosphate; or ii) a 5′-terminal unmodified phosphate and a modified sugar moiety comprising a 5′ modification; and a linking group linking the phosphate stabilizing nucleoside to the remainder of the oligonucleotide; and wherein the remainder of the oligonucleotide comprises at least one region having a nucleoside motif: A and B are differently modified nucleosides; and each n is independently selected from 1, 2, 3, 4, and 5; or iii) both i) and ii).