Patent ID: 7119111
Filing Date: 2006-10-10
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein A is O or S; wherein D is selected from CR wherein E is selected from CR wherein F is selected from CR wherein G is selected from CR wherein J is selected from NR wherein K is selected from NR wherein L is selected from NR wherein Q is selected from H, hydroxy, —N(R substituted aryl, an unsubstituted or substituted monocyclic or bicyclic, non-aromatic carbocyclic ring, an unsubstituted or substituted monocyclic or bicyclic, heteroaryl and an unsubstituted or substituted monocyclic or bicyclic, non-aromatic heterocyclic ring, wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , —(C 1 –C 8 )alkyl-N(R 5 ) 2 , —(C 1 –C 8 )alkyl-S(O) n R 5 , —N(R 5 ) 2 (C 1 –C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —S(O) n R 5 , —NR 5 S(O) n R 5 , cyano, (C 1 –C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 –C 10 cycloalkyl, nitro, optionally substituted 4–7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5 and —C(O)R 5 ; wherein W is selected from thienyl, thiazolyl, oxazolyl, imidazolyl, pyrrolyl, furyl, pyrazolyl, isoxazolyl, thiadiazolyl, triazolyl and isothiazolyl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 –C 8 )alkenyl, (C 2 –C 8 )alkynyl, —N(R 5 ) 2 , —(C 1 –C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 –C 8 )alkyl-SO 2 R 5 , —(C 1 –C 8 )alkyl-SO 2 —(C 1 –C 8 )alkyl-R 5 , —C 1 –C 8 )alkyl-SO 2 —(C 1 –C 8 )aryl, —(C 1 –C 8 )alkyl-SO 2 —(C 1 –C 8 )heteroaryl, (C 1 –C 8 )alkyl, (C 3 –C 10 )cycloalkyl, nitro, cyano, optionally substituted 5–6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 S(O) n R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 and —NR 5 CO 2 R 5 ; wherein Y is selected from H, —N(R wherein Z is selected from H, —N(R wherein n is 0, 1 or 2; wherein R wherein R wherein R wherein R wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R wherein each aryl, heteroaryl, cycloalkyl, and heterocyclyl moiety of any R provided Q is not pyridinium; further provided the compound is not 3-(2-pyridin-3-yl-thiazol-4-yl)-3,4-dihydro-1H-quinazolin-2-one or 6-methyl-3-(2-pyridin-2-yl-thiazol-4-yl)-3,4-dihydro-1H-quinazolin-2-one, and pharmaceutically acceptable salt thereof.