Patent ID: 7544839
Filing Date: 2009-06-09
Classification: A61P,C07C,Y02E

Abstract:
1. A process for the synthesis of a compound of formula (I) wherein 7-methoxy-1-tetralone of formula (III): is reacted with cyanoacetic acid of formula (IV): wherein the water formed during the reaction is removed, in the presence of a catalytic amount of a compound of formula (V): wherein R and R′, which may be the same or different, each represents linear or branched (C to yield, after filtration and washing with a basic solution, (7-methoxy-3,4-dihydro-1-naphthalenyl)acetonitrile of formula (VI): the compound of formula (VI) thus obtained is reacted with a hydrogenation catalyst in the presence of an allyl compound to yield a compound of formula (VII): the compound of formula (VII) thus obtained is then subjected to reduction with hydrogen in the presence of Raney nickel in an ammoniacal ethanol medium, and subsequently converted to a salt using hydrochloric acid to yield a compound of formula (VIII): the compound of formula (VIII) thus obtained is subjected successively to the action of sodium acetate and then acetic anhydride to yield the compound of formula (I), which is isolated in the form of a solid, it being understood that: