Patent ID: 8591935
Filing Date: 2013-11-26
Classification: A61K,A61P

Abstract:
1. A method of treating pain and/or inflammation from sciatica or spondylolisthesis in a patient in need of such treatment, the method comprising locally administering one or more drug depots comprising a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof, a therapeutically effective amount of a glial cell-derived neurotropic factor and a polymer having an average molecular weight of about 1,000 to about 10,000, a particle size of about 10 micrometers to about 250 micrometers and a L/G ratio of 65:35 having a duration of delivery of about 2 months at or near a target tissue site beneath the skin of the patient to treat sciatic or spondylolisthesis pain and/or inflammation, wherein the one or more drug depots release 0.1 mg/kg/day to about 3 mg/kg/day of the statin at or near the target tissue site and has a modulus of elasticity of about 1×10 4 to about 6×10 5 dynes/cm 2 .