Patent ID: 6297249
Filing Date: 2001-10-02
Classification: C07D

Abstract:
A compound of the formula ##STR77##wherein R.sup.1 selected from the group consisting ofhydrogen, halogen, C.sub.1-10 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloheteroalkyl, C.sub.3-8 cycloalkyl C.sub.1-6 alkyl, C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl, aryl, aryl C.sub.1-8 alkyl, amino, amino C.sub.1-8 alkyl, C.sub.1-3 acylamino, C.sub.1-3 acylamino C.sub.1-8 alkyl, (C.sub.1-6 alkyl).sub.p amino, (C.sub.1-6 alkyl).sub.p amino C.sub.1-8 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy C.sub.1-6 alkyl, hydroxycarbonyl, hydroxycarbonyl C.sub.1-6 alkyl, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkoxycarbonyl C.sub.1-6 alkyl, hydroxycarbonyl-C.sub.1-6 alkyloxy, hydroxy, hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkyloxy-C.sub.1-6 alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, trifluoroethoxy, C.sub.1-8 alkyl-S(O).sub.p, (C.sub.1-8 alkyl).sub.p aminocarbonyl, C.sub.1-8 alkyloxycarbonylamino, (C.sub.1-8 alkyl).sub.p aminocarbonyloxy, (aryl C.sub.1-8 alkyl).sub.p amino, (aryl).sub.p amino, aryl C.sub.1-8 alkylsulfonylamino, and C.sub.1-8 alkylsulfonylamino;R.sup.5 is selected from the group consisting ofaryl,aryl-C.ident.C--(CH.sub.2).sub.t --,aryl C.sub.1-6 alkyl,CH.sub.2.dbd.CH--(CH.sub.2).sub.t --, andHC.ident.C--(CH.sub.2).sub.t --; andR.sup.9 is selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,aryl,aryl C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,aryl C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,C.sub.1-8 alkylaminocarbonylmethylene, andC.sub.1-8 dialkylaminocarbonylmethylene;whereineach m is independently an integer from 0 to 6;each p is independently an integer from 0 to 2; andeach t is independently an integer from 0 to 3;and the pharmaceutically acceptable salts thereof.