Patent ID: 8591419
Filing Date: 2013-11-26
Classification: A61B,A61N,C12N

Abstract:
1. A method for modulating neuronal cellular activity of a neuronal cellular site in a subject, comprising: (i) acoustically coupling at least one component for generating ultrasound waves to an external surface of the subject, and (ii) driving the at least one component for generating ultrasound waves to form at least one stimulus waveform at the neuronal cellular site, the stimulus waveform comprising a plurality of pulses, each pulse of the plurality comprising a plurality of acoustic cycles having one or more frequencies in a range from about 0.02 to about 100 MHz at the site of the cells to be modulated, wherein each of the plurality of pulses comprises a plurality of frequencies and wherein pulses of the plurality are repeated at a pulse repetition frequency ranging from about 0.001 to about 100 KHz to produce spatial-peak temporal-average intensities ranging from about 0.0001 to about 900 mW/cm