Patent ID: 6169111
Filing Date: 2001-01-02
Classification: A61K,C07C

Abstract:
A method of treating glaucoma and ocular hypertension which comprises topically administering to the affected eye a therapeutically effective amount of a compound of formula (I) ##STR3## wherein: Y.dbd.C(O)NR.sub.1 R.sub.2, CH.sub.2 OR.sub.3, CH.sub.2 NR.sub.1 R.sub.2, CO.sub.2 R.sub.1, or CO.sub.2 M, where M is a cationic salt moiety; R.sub.1, R.sub.2 (same or different).dbd.H, C.sub.1 -C.sub.6 alkyl or alkenyl, or C.sub.3 -C.sub.6 cycloalkyl; R, R.sub.3 (same or different).dbd.C(O)R.sub.4 or H, where R.sub.4.dbd.C.sub.1 -C.sub.6 alkyl or alkenyl, or C.sub.3 -C.sub.6 cycloalkyl; A.dbd.CH.sub.2 CH.sub.2, cis or trans CH.dbd.CH, or C.tbd.C; Z.dbd.CH.sub.2 CH.sub.2 or trans CH.dbd.CH; X.dbd.[O, S(O).sub.n,](CH.sub.2).sub.n, where n=0, 1, or 2; B.dbd.H and OH in either configuration or double bonded O; D.dbd.R.sub.1, OR.sub.1, halogen, S(O).sub.n R.sub.4, NO.sub.2, NR.sub.1 R.sub.2, H, or CF.sub.3, where n=0, 1, or 2, and R.sub.1, R.sub.2 and R.sub.4 are as defined above; and m=0, 1,or 2.