Patent ID: 9198995
Filing Date: 2015-12-01
Classification: A61L,A61P

Abstract:
1. A composite nonwoven article of filled polymeric macrofibers for use as a therapeutic dressing in the treatment of a wound site of a mammalian subject, comprising: multiple networks of microfibers, each of the multiple networks of microfibers including multiple submicron-diameter polymeric microfibers having diameters of between about 50 nm and about 500 nm and containing and binding therapeutic agent particles in a configuration that presents a large available surface area of therapeutic agent with insubstantial blockage by the microfibers, the networks of microfibers exhibiting intra-fiber porosity produced by free spaces around the therapeutic agent particles and the microfibers; and multiple micron-diameter porous polymeric macrofibers, each of the multiple polymeric macrofibers having a diameter of greater than 10 μm and less than about 500 μm presenting a structured architecture formed of one of the multiple networks of microfibers containing and binding therapeutic agent particles, the macrofibers randomly oriented to form a composite nonwoven article exhibiting inter-fiber porosity around the macrofibers, the randomly oriented macrofibers of the composite nonwoven article exhibiting intra- and inter-fiber porosity at submicron and micron scales with appreciable free space around the therapeutic agent particles contained and bound by the network of microfibers so that blood from the wound site penetrates the composite nonwoven article of filled polymeric macrofibers to come in contact with a substantial amount of the therapeutic agent and thereby stimulate a therapeutic response in the mammalian subject.