Patent ID: 6087339
Filing Date: 2000-07-11
Classification: A61P,B01J,C07H,C40B

Abstract:
A compound of formula I: ##STR10## wherein A is an animal saccharide which is not D-galactose;R.sup.1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl;R.sup.2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl;R.sup.3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl;or R.sup.1 and R.sup.2, or R.sup.1 and R.sup.3, or R.sup.2 and R.sup.3, or R.sup.1, R.sup.2 and R.sup.3 can be joined, together with the carbon atoms to which R.sup.1 and/or R.sup.2 and/or R.sup.3 are attached, to form a cycloalkyl, cycloalkenyl or heterocyclic ring;R.sup.4 is selected from the group consisting of --XR.sup.5, --XC(W)R.sup.6, --XC(W)X'R.sup.7 and --C(W)XR.sup.8 ; wherein W is selected from the group consisting of oxygen, sulfur and NH; and X and X' are each independently selected from the group consisting of oxygen, sulfur and --NR.sup.9 --, wherein R.sup.9 is selected from the group consisting of hydrogen and alkyl; or when R.sup.4 is --XR.sup.5 and R.sup.5 is not hydrogen, X can also be selected from the group consisting of --S(O)-- and --SO.sub.2 --;R.sup.5 is selected from the group consisting of hydrogen, allyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl, and when X is --NR.sup.9 --, then R.sup.9 together with X can form an amino acid; or R.sup.5 and R.sup.1, or R.sup.5 and R.sup.2, or R.sup.5 and R.sup.3 can be joined, together with X of the --XR.sup.5 group and the carbon atoms to which R.sup.1 and/or R.sup.2 and/or R.sup.3 are attached, to form a heterocyclic ring;R.sup.6 is selected from the group consisting of alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; or R.sup.6 and R.sup.1, or R.sup.6 and R.sup.2, or R.sup.6 and R.sup.3 can be joined, together with the --XC(W)-- moiety of the --XC(W)R.sup.6 group and the carbon atoms to which R.sup.1 and/or R.sup.2 and/or R.sup.3 are attached, to form a heterocyclic ring;R.sup.7 is selected from the group consisting of alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; or R.sup.7 and R.sup.1, or R.sup.7 and R.sup.2, or R.sup.7 and R.sup.3 can be joined, together with the --XC(W)X'-- moiety of the --XC(W)X'R.sup.7 group and the carbon atoms to which R.sup.1 and/or R.sup.2 and/or R.sup.3 are attached, to form a heterocyclic ring;R.sup.8 is selected from the group consisting of alkyl, alkenyl, alkaryl, alkoxyalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic and thioalkoxyalkyl; or R.sup.8 and R.sup.1, or R.sup.8 and R.sup.2, or R.sup.8 and R.sup.3 can be joined, together with the --C(W)X-- moiety of the --C(W)XR.sup.8 group and the carbon atoms to which R.sup.1, R.sup.2 and/or R.sup.3 are attached, to form a heterocyclic ring;Y is selected from the group consisting of oxygen, sulfur, --S(O)-- and --S(O).sub.2 --;n is an integer equal to 0 or 1; and pharmaceutically acceptable salts thereof;with the proviso that when Y is sulfur, --S(O)-- or --S(O).sub.2 --, R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are selected so as to form at least one cycloalkyl, cycloalkenyl or heterocyclic ring; and when Y is oxygen, R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are selected so as to form at least two cycloalkyl, cycloalkenyl or heterocyclic rings.