Patent ID: 8383919
Filing Date: 2013-02-26
Classification: A61K,B82Y

Abstract:
1. A fluorescent metal nanocluster bioprobe, comprising: a peptide templated fluorescent metal nanocluster, wherein said peptide molecule has a structure of X-Z chemical formula wherein X and Z are covalently bonded, X being a chemical side group selected from a chemical functional groups consisting of hydroxybenzene, carboxylic, guanidino, amide, sulfhydryl, amidocyanogen, indole and imidazole, Z being a specific peptide sequence for targeting a specific biological target, X being either at the N-terminal or the C-terminal of Z; said metal being either gold or silver and said metal atom and said peptide molecule form a nanocluster complex structure that emits fluorescent light under sufficient exciting condition, and wherein said peptide templated fluorescent metal nanocluster is produced by an one-step reaction of mixing a solution of said peptide molecule with a solution of either chloroauric acid or silver nitrate at a sufficient molar ratio under ambient temperature at sufficient pH for a sufficient period of time.