Patent ID: 6610714
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of the formula I: where;R1 is O, S; R2 is an optionally substituted, nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto and the like; X is â€”(CR8R9)nâ€”R8 and R9 are independently H, C1-C3 alkyl, OH or R8 and R9 together are &boxH;O n is 1, 2 or 3 and prodrugs and pharmaceutically acceptable salts thereof.