Patent ID: 9035026
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody or antigen-binding fragment thereof having specificity for FcγRIIIA but does not bind to FcγRIIIB, comprising: (a) a heavy chain CDR1 having the amino acid sequence set forth in SEQ ID NO:17; a heavy chain CDR2 having the amino acid sequence set forth in SEQ ID NO:18; a heavy chain CDR3 having the amino acid sequence set forth in SEQ ID NO:19; a light chain CDR1 having an amino acid sequence selected from the group consisting of SEQ ID NOs:20, 23, 26, 29, 33, and 34; a light chain CDR2 having an amino acid sequence selected from the group consisting of SEQ ID NOs:21, 24, 27, 30, 31, and 35; and a light chain CDR3 having an amino acid sequence selected from the group consisting of SEQ ID NOs:22, 25, 28, and 32; or (b) a light chain variable region having an amino acid sequence selected from the group consisting of SEQ ID NOs:10-16 and a heavy chain variable region; or (c) a heavy chain variable region having the amino acid sequence set forth in SEQ ID NO:9 and a light chain variable region, wherein the antigen-binding fragment is selected from the group consisting of Fv, Fab, di-Fab, Fab′, F(ab′)