Patent ID: 6652600
Filing Date: 2003-11-25
Classification: A61K,A61Q,C07C

Abstract:
An acid addition salt of a compound of formula (1), wherein:X1 and X2, which may be identical or different, are each independently chosen from hydroxyl groups, â€”NHR1 groups, and â€”NR1R2 groups, provided that X1 and X2 are not simultaneously a hydroxyl group; R1 and R2, which may be identical or different, are each independently chosen from hydrogen atoms, C1-C8 alkyl groups, C1-C8 monohydroxyalkyl groups, C2-C8 polyhydroxyalkyl groups, C2-C8 aminoalkyl groups, mono(C1-C4)alkylamino(C1-C4)alkyl groups, di(C1-C4)alkylamino(C1-C4)alkyl groups and C1-C8 haloalkyl groups; wherein when at least one group chosen from X1 and X2 is a â€”NR1R2 group, then R1 and R2 of said â€”NR1R2 group may form, together with the nitrogen atom to which they are attached, a ring structure chosen from aromatic 4-, 5- and 6-membered rings and non-aromatic 4-, 5- and 6-membered rings; R1 and R2, which may be identical or different, may also independently be chosen from aromatic 4-, 5- and 6-membered rings and non-aromatic 4-, 5- and 6-membered rings, wherein said rings may comprise at least one heteroatom; A is a divalent group chosen from â€”CH&boxH;Nâ€” and â€”CH2â€”NHâ€”; Z is a group chosen from a hydrogen atom, a halogen atom, aromatic 4-, 5- and 6-membered rings, non-aromatic 4-, 5- and 6-membered rings, C1-C8 alkyl groups, C1-C8 monohydroxyalkyl groups, C2-C8 polyhydroxyalkyl groups, C2-C8 aminoalkyl groups, mono(C1-C4)alkylamino(C1-C4)alkyl groups, di(C1-C4)alkylamino(C1-C4)alkyl groups, C1-C8 haloalkyl groups, cyano groups and â€”BR3 groups wherein B is a divalent group chosen from the groups: â€ƒand wherein R3 is chosen from C1-C8 alkyl groups, C1-C8 monohydroxyalkyl groups, C2-C8 polyhydroxyalkyl groups, C2-C8 aminoalkyl groups, mono(C1-C4)alkylamino(C1-C4)alkyl groups, di(C1-C4)alkylamino(C1-C4)alkyl groups and C1-C8 haloalkyl groups; and with the proviso that when A is â€”CH&boxH;Nâ€”, X1 is â€”NHR1 wherein R1 is a hydrogen atom, and X2 is â€”NR1R2 wherein R1 and R2 of said â€”NR1R2 group form, together with the nitrogen atom to which they are attached, a ring structure chosen from non-aromatic 6-membered rings, and said non-aromatic 6-membered rings are chosen from piperazine and piperidine, then Z is not a hydrogen atom; and wherein the acid addition salt of the compounds of formula (I) is chosen from hydrochlorides, hydrobromides, sulphates, citrates, succinates, tartrates, lactates and acetates.