Patent ID: 6384055
Filing Date: 2002-05-07
Classification: A61K,A61P

Abstract:
A method of treating acute pain, neuropathic pain or nociceptive pain in a mammal which comprises administering to a patient in need thereof an effective amount of a derivative of tetrahydropyridines of formula (I) whereR1, R2 and R3 are identical or different and are selected from hydrogen, C1-C4 alkyl group, trifluoroethyl radical, hydroxyl or alkoxyl radical; and two adjacent radicals can form part of a six-membered aromatic ring; A is selected from a carbon atom or a carbon atom bound to a hydroxyl group (Câ€”OH); wherein when A is a carbon atom the dotted line (- - -) represents a bond, and when A is a carbon atom bound to a hydroxyl group (Câ€”OH) the dotted line (- - -) represents no bond; Z1, is a nitrogen atom or a substituted carbon atom represented by the formula Câ€”R4; Z2 is a nitrogen atom or a substituted carbon atom represented by the formula Câ€”R5; Z4 is a nitrogen atom or a substituted carbon atom represented by the formula Câ€”R7; with the condition that Z1; Z2 and Z4 taken together can represent at most, two nitrogen atoms; and R4, R5, R6 and R7, are identical or different and are selected from hydrogen, halogen, C1-C4 alkyl group, aryl or substituted aryl group, and two adjacent radicals can form part of a six-membered aromatic ring; or physiologically acceptable salts thereof.