Patent ID: 6313292
Filing Date: 2001-11-06
Classification: C07D

Abstract:
A process for the preparation of a compound of Formula I ##STR39##wherein R is aryl, alkyl, or arylalkyl;R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of:hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl, aminoalkyl, diaminoalkyl, carboxyalkyl, hydroxyalkylaminoalkyl, dihydroxyalkylaminoalkyl, andR.sup.1 and R.sup.2 may be combined with N to form a 5-or 6-membered ring optionally containing an N, O, or S atom wherein the N atom may be optionally substituted by an alkyl group; and pharmaceutically acceptable salts thereof which comprises:Step (A) reacting a compound of Formula II ##STR40##wherein R is as defined above with a compound of Formula III ##STR41##wherein R.sup.1 and R.sup.2 are as defined above in a dipolar aprotic solvent to afford a compound of Formula I; andStep (B), if desired, converting a compound of Formula I to a corresponding pharmaceutically acceptable salt by conventional means, and, if so desired, converting the corresponding phramaceutically acceptable salt to a compound of Formula I by conventional means.