Patent ID: 7781195
Filing Date: 2010-08-24
Classification: A61M,A61N,C12M

Abstract:
1. A device for manipulating a molecule in vivo relative to a target tissue comprising: a plurality of generally cylindrical nonconducting core posts for insertion into the target tissue, each of the plurality of core posts comprising at least three discrete electrodes, each of the at least three discrete electrodes being circumferential rings disposed to surround the nonconductive core post and each of the at least three electrodes positioned in axially spaced apart relation along the nonconducting core post, each electrode being in independent circuit communication with a respective portion of a source of electrical energy, the electrodes being configured to establish a first electromagnetic field in vivo between selected electrodes sufficient to cause electromigration of a molecule through the target tissue along the axial length of the core post between the selected electrodes and a second electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue between the selected electrodes and an insulating material interposed axially between the circumferential ring electrodes for achieving relative electromagnetic isolation of the electrodes; and the plurality of core posts affixed to the support member and the plurality of core posts being disposed about the support member in spaced relation from each other and the plurality of core posts extending in an axial direction from the support member such that the plurality of core posts are perpendicular to the support member along the axial length of the core posts, the plurality of core posts configurable to surround a periphery of at least a portion of the target tissue.