Patent ID: 8946432
Filing Date: 2015-02-03
Classification: A61K,C07D

Abstract:
1. A compound of formula (I), its tautomeric forms, its stereoisomers, its sulfoxides, its N-oxides, its pharmaceutically acceptable salts, its polymorphs, its solvates, or its optical isomers wherein, ‘D’ is selected from N and CR ‘E’ is selected from S and NR with a proviso that when ‘E’ is NR R R R ‘n’ is selected from 0, 1, 2 and 3; R ‘m’ is selected from 0, 1, 2 and 3; R R R R R R the substituents on ‘alkyl’ and ‘alkenyl’ are selected from the group consisting of oxo, halogen, nitro, cyano, perhaloalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, R the substituents on ‘cycloalkyl’ and ‘cycloalkenyl’ are selected from the group consisting of oxo, halogen, nitro, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, perhaloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, R the substituents on ‘aryl’ are selected from the group consisting of halogen, nitro, cyano, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, perhaloalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted- or unsubstituted- heterocycle, alkyl-O—, perhaloalkyl-O—, alkyl(alkyl)N—, alkyl(H)N—, H the substituents on ‘heteroaryl’ are selected from the group consisting of halogen, nitro, cyano, hydroxy, substituted- or unsubstituted- alkyl, substituted- or unsubstituted- alkenyl, perhaloalkyl, substituted- or unsubstituted- cycloalkyl, substituted- or unsubstituted- cycloalkenyl, substituted- or unsubstituted- heterocycle, alkyl-O—, perhaloalkyl-O—, alkyl(alkyl)N—, alkyl(H)N—, H the substituents on ring carbon of ‘heterocycle’ is selected from the group consisting of halogen, nitro, cyano, oxo, substituted- or unsubstituted- alkyl, substituted- or unsubstituted- alkenyl, perhaloalkyl, substituted- or unsubstituted- cycloalkyl, substituted- or unsubstituted- cycloalkenyl, substituted- or unsubstituted- aryl, substituted- or unsubstituted- heteroaryl, substituted- or unsubstituted- heterocyclyl, substituted- or unsubstituted- alkyl, R the substituents on ring nitrogen of ‘heterocycle’ is selected from the group consisting of substituted- or unsubstituted- alkyl, substituted- or unsubstituted- alkenyl, substituted- or unsubstituted- cycloalkyl, substituted- or unsubstituted- cycloalkenyl, substituted- or unsubstituted- aryl, substituted- or unsubstituted- heteroaryl, R the “5 to 8 membered cyclic system” is substituted with 1 to 3 substituents selected from the group consisting of halogen, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, R R R R A