Patent ID: 8133976
Filing Date: 2012-03-13
Classification: A61P,G01N,Y10S

Abstract:
1. A method of inhibiting cellular activation through the binding of TACI (SEQ ID NO:2) to TACI-L (SEQ ID NO:4), comprising (a) exposing a cell expressing a TACI-L polypeptide of SEQ ID NO:4 to a TACI-Fc conjugate comprising amino acids 2-166 of SEQ ID NO:2 conjugated to a human Fc domain; (b) allowing the TACI-Fc conjugate to bind the TACI-L polypeptide; and (c) inhibiting the binding of an endogenous TACI polypeptide comprising SEQ ID NO:2 to the TACI-L polypeptide and thereby inhibiting the activation of the cell.