Patent ID: 6387899
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of the formula I whereinX is N or CH; Y is CH2â€”NR2, NR2â€”CO, COâ€”NR2 or NR2SO2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6, alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aromatic ring, wherein the aromatic ring is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from the soup consisting of N, O and S and wherein the aromatic ring may be mono- or di-substituted with R4 and/or R5; wherein R4 is H, C1-C6 alkyl, C3-C6 cycloalkyl, halogen, CN, CF3, OH, C1-C6 alkoxy, NR6R7, OCF3, SO3CH3, SO3CF3, SO2NR6R7, phenyl, phenylâ€”C1-C6 alkyl, phenoxy, C1-C6 alkylphenyl, an optionally substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N, O, S, SO and SO2 wherein the substituent(s) is(are) selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl and phenylâ€”C1-C6 alkyl; or COR8; wherein R6 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R7 is H, C1-C6 alkyl or C3-C6 cycloalkyl; and R8 is C1-C6 alkyl, C3-C6 cycloalkyl, CF3, NR6R7, phenyl, or a heterocyclic ring containing one or two heteroatoms, selected from the group consisting of N O, S, SO and SO2; wherein R5 is H, OH, CF3, OCF3, halogen, C1-C6 alkyl or C1-C6 alkoxy; n is 0-4; R9 is C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CONR6R7, CN, CF3, OH, C1-C6 alkoxy, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl, or COR8; wherein R6, R7 and R8 are as defined above, wherein the compound is an (R)-enantiomer, an (S)-enantiomer, or a racemate in the form of a free base or a pharmaceutically acceptable salt or solvate thereof.