Patent ID: 7968540
Filing Date: 2011-06-28
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein A 1 , A 2 and A 3 are each independently selected from: (1) a bond, (2) —CR (3) —NR (4) —CR (5) —CR (6) —CH (7) —O—CR (8) —CR (9) —C≡C—, (10) —C(R (11) —C(═O)—, 0-1 of A 4 , A 5 , A 6 and A 7 is: —C(═O)—, where the remainder of A 4 , A 5 , A 6 and A 7 are each independently selected from: B (1) a bond, or (2) —CR B 1 are each independently selected from: (1) (2) or (3) B B 2 and B 3 are each independently selected from: (1) a bond (2) ═C(R (3) —CR (4) —C(═O)—, (5) —C(═S)—, or (6) —C(═NR D 1 and D 2 are each independently selected from: (1) ═C(R (2) —CR (3) —C(═O)—, (4) —C(═S)—, (5) ═N—, (6) —N(R (7) —C(═NR E 1 and E 5 are each independently selected from: (1) ═C(R (2) —CR (3) —C(═O)—, (4) —C(═S)—, (5) ═N—, (6) ═N (7) —N(R E 3 and E 4 are each independently selected from: (1) a bond, (2) ═C(R (3) —CR (4) —C(═O)—, (5) ═N—, (6) ═N (7) —N(R E 2 is selected from: (1) (2) or (3) G 1 and G 2 are independently defined as: (1) ═C(R T, U and V are each independently selected from: ═C(R W, X, Y, and Z are each independently selected from: (1) a bond (2) ═C(R (3) —CR (4) —C(═O)—, (5) —C(═S)—; or R 1 and R 2 are each independently selected from: (1) hydrogen; (2) —C (3) —C (4) phenyl or heterocycle, wherein heterocycle is selected from: pyridinyl, pyrimidinyl, pyrazinyl, thienyl, pyridazinyl, pyrrolidinyl, azetidinyl, azepanyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, triazolyl, tetrazolyl, azepinyl, benzimidazolyl, benzopyranyl, benzofuryl, benzothiazolyl, benzoxazolyl, chromanyl, furyl, imidazolinyl, indolinyl, indolyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, isoindolinyl, tetrahydroisoquinolinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, pyrazolidinyl, pyrazolyl, pyrrolyl, quinazolinyl, tetrahydrofuryl, thiazolinyl, purinyl, naphthyridinyl, quinoxalinyl, 1,3-dioxolanyl, oxadiazolyl, piperidinyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, or morpholinyl, which phenyl or heterocycle is unsubstituted or substituted with 1-5 substituents each independently selected from: (5) halo, (6) oxo, (7) hydroxy, (8) —O—C (9) —CN, (10) —CO (11) —NR (12) —SR (13) —S(O)R (14) —SO (15) —SO (16) —CONR (17) —OCO (18) —(NR (19) —O(CO)NR (20) —(NR (21) —(CO)—(CO)NR (22) —(CO)—(CO)OR R 4 and R 5 are each independently selected from: (1) hydrogen; (2) —C (3) —C (4) phenyl, which is unsubstituted or substituted with 1-3 substituents where the substituents are each independently selected from: (5) halo, (6) hydroxy, (7) —O—C (8) —CN, (9) —CO (10) —NR (11) —SO (12) —CONR (13) —OCO (14) —(NR R 6 is selected from: (1) hydrogen, (2) —C (3) phenyl or heterocycle, wherein heterocycle is selected from: pyridinyl, pyrimidinyl, pyrazinyl, thienyl, or morpholinyl, which phenyl or heterocycle is unsubstituted or substituted with 1-5 substituents each independently selected from: or a pharmaceutically acceptable salt thereof or an individual enantiomer or diastereomer thereof.