Patent ID: 6348457
Filing Date: 2002-02-19
Classification: A61K,A61P,C07D

Abstract:
A method of antagonizing the action of reserpine in warm blooded animals which comprises the administration to warm blooded animals of a therapeutically effective amount of a compound of the formula: a pharmaceutically acceptable acid addition salt thereof or a stereochemically isomeric form thereof, wherein:X is oxygen or sulfur; R1 is hydrogen or halo; R2 is hydrogen, C1-4alkyl, phenyl methyl or halophenylmethyl; Alk is C1-4alkanediyl; and â€”Zâ€”Aâ€” is a bivalent radical selected from the group consisting of â€”Sâ€”CH2â€”CH2â€”, â€”Sâ€”CH2â€”CH2â€”CH2â€”, â€”Sâ€”CH&boxH;CHâ€”, â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, â€”C(&boxH;CHR3)â€”CH2â€”CH2â€”CH2â€”, â€”CH&boxH;CHâ€”Oâ€”, â€”CHR4â€”CH2â€”CH2â€”, â€”CHR4â€”CH2â€”CH2â€”CH2â€”, and â€”CHR4â€”CH2â€”CH2â€”CH2â€”CH2â€”; wherein in said bivalent radicals: one hydrogen may be replaced by C1-4alkyl; R3 is phenyl or halo phenyl; and each R4 independently represents hydrogen, hydroxy, phenylmethyl or halophenylmethyl.