Patent ID: 6610875
Filing Date: 2003-08-26
Classification: C07B,C07C,C07F

Abstract:
A process for preparing a compound of formula I: in which:A represents an optionally substituted phenyl or naphthyl; and Ar1 and Ar2 independently represent an optionally substituted saturated or aromatic carbocyclic group; this process comprising the steps comprising: i) brominating a diol of formula II: â€ƒin which A is as defined above, using a suitable brominating agent so as to obtain a dibromo compound of formula III: â€ƒin which A is as defined above; ii) esterifying the compound of formula III obtained in the preceding step by the action of a sulfonic acid or an activated form thereof, so as to obtain the corresponding disulfonate; iii) substituting the two bromine atoms with cyano groups by reacting the disulfonate obtained in the preceding step with a suitable nucleophilic agent so as to obtain the corresponding nitrile; iv) coupling a phosphine of formula VI: XPAr1AR2â€ƒâ€ƒ(VI) â€ƒin which X represents a hydrogen atom or a halogen atom and Ar1 and Ar2 are as defined above, with the nitrile obtained in the preceding step, in the presence of a catalyst based on a transition metal, so as to obtain the compound of formula I.