Patent ID: 8404271
Filing Date: 2013-03-26
Classification: A61K,A61L,A61P,B29K,B29L,G02B

Abstract:
1. A drug delivery system comprising: a contact lens, the contact lens comprising a weakly cross-linked hydrogel matrix having between about to 0.1% to 20% moles cross-linking monomer and/or macromer species per total moles of all monomer and/or macromer species present, wherein the matrix has complexing sites that complex a drug and release the drug from the weakly cross-linked hydrogel matrix over time while in contact with a surface of an eye, wherein the weakly cross-linked hydrogel matrix is formed by generating a solution comprising amounts of a bio-template, a functionalized monomer and a cross-linking monomer and initiating copolymerization of the functionalized monomer and the cross-linking monomer, and loading the hydrogel matrix with the drug, wherein the functionalized monomer and the bio-template are in the solution through non-covalent interactions; and wherein the functionalized monomer contains functional groups that mimic receptor sites of a target biological tissue that are associated with a biological mechanism of the drug at that biological tissue.