Patent ID: 7217525
Filing Date: 2007-05-15
Classification: G01N

Abstract:
1. A method for identifying a compound which affects the formation of AMPA receptors into aggregates, comprising: (a) incubating a test compound and a pre-synaptic cell expressing a long pentraxin under conditions sufficient to allow the compound to interact with the cell, wherein the long pentraxin is Narp or NP-1; (b) determining the effect of the compound on the formation of AMPA receptors into aggregates in said pre-synaptic cell or in a post-synaptic cell synapsing with said pre-synaptic cell; and (c) comparing the formation of AMPA receptors into aggregates of said pre-synaptic cell contacted with said compound, or in said post-synaptic cell not contacted with said compound or a post-synaptic cell synapsing with said pre-synaptic cell not contacted with said compound.