Patent ID: 6576783
Filing Date: 2003-06-10
Classification: C07C,C07D,C07F,C07H,Y02P

Abstract:
A method of preparing a compound of formula (IX) whereinR is H, or a guanidino protecting group; Q is â€”Xâ€”(CR5R6)nâ€”CR3R4â€”Yâ€”R2; X is aryl or a covalent bond; Y is aryl or a covalent bond; R2 is cyano, nitro or CF3; R3 and R4 are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl and cycloalkyl-alkyl; W is C(R5)(R6) or C(R7)&boxH;C(R7) where each R5, R6, and R7 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl and cycloalkyl-alkyl or both R7 substituents together form an unsaturated aromatic ring; and n is an integer from 0 to 7; comprising the steps of:reacting a compound of formula (VIII) with an amine, wherein Râ€² is a thiopseudourea protecting group.