Patent ID: 7538112
Filing Date: 2009-05-26
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein: R 1 is: (1) —C (2) —C (3) —C (4) —C (5) heteroaryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of substituents (1) to (26) as defined below in part (i) of Part B of the definition of R (6) —C (7) aryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (21) as defined above in part (i) of Part A of the definition of R R 2 is: (1) —H, (2) —C (3) —C (4) —C (5) —C or alternatively R 1 and R 2 together with the ring nitrogen to which R 1 is attached and the ring carbon to which R 2 is attached form a 5- to 7-membered, saturated heterocyclic ring in which the portion of the ring formed from R 1 and R 2 is a 3- to 5-membered methylene chain in which one of the methylene moieties is optionally replaced with N(H), wherein the chain is optionally substituted with from 1 to 3 substituents each of which is independently —C 1-6 alkyl, —OH, or oxo; R 3 is: (1) —H, (2) —C (3) —C (4) —C (5) —C (6) CycM, AryM, or HetM, or (7) —C or alternatively R 2 and R 3 together with the carbon atoms to which they are attached form: (i) a 3- to 8-membered saturated carbocyclic ring which is optionally substituted with from 1 to 6 substituents each of which is independently halogen, —CN, —C (ii) a benzene ring, which is optionally substituted with from 1 to 4 substituents each of which is independently any one of the substituents (1) to (21) as defined above in part (i) of Part A of the definition of R (iii) a 4- to 7-membered, saturated or mono-unsaturated heterocyclic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O) (iv) a 5- or 6-membered heteroaromatic ring, which is optionally substituted with from 1 to 3 substituents each of which is independently any one of the substituents (1) to (26) as defined above in part (i) of Part B of the definition of R wherein R R 4 is: (1) —H, (2) —C (3) —C (4) —C (5) —OH, (6) —O—C (7) —O—C (8) —CN, (9) —NO (10) —N(R (11) —C(O)N(R (12) —C(O)R (13) —CO (14) —SR (15) —S(O)R (16) —SO (17) —SO (18) —N(R (19) —N(R (20) —N(R (21) —N(R (22) —OC(O)N(R (23) —N(R (24) —N(R (25) halogen, (26) —S—C(O)N(R (27) —N═C(R (28) —C(O)N(R (29) —C(O)—C (30) —C(O)N(R (31) —C(O)—C (32) —N(SO (33) —N[C(O)R (34) —C (35) —C (36) —T—R CycL is —C 3-8 cycloalkyl which is optionally substituted with from 1 to 6 substituents each of which is independently halogen, —CN, —C 1-6 alkyl, —OH, —O—C 1-6 alkyl, —C 1-6 haloalkyl, or —O—C 1-6 haloalkyl; AryL is aryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (21) as defined above in part (i) of Part A of the definition of R J ; HetE independently has the same definition as HetC; HetL is heteroaryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (26) as defined above in part (i) of Part B of the definition of R J ; HetS is a 4- to 7-membered, saturated or mono-unsaturated heterocyclic ring containing at least one carbon atom and from 1 to 4 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O) 2 , with the proviso that HetS is attached to the rest of the molecule via a ring carbon atom; and wherein the saturated or mono-unsaturated heterocyclic ring is optionally substituted with from 1 to 4 substituents each of which is independently halogen, —CN, —C 1-6 alkyl, —OH, oxo, —C(O)R A , —CO 2 R A , —S(O)R A , —SR A , —S(O) 2 R A , —CH 2 —CH═CH 2 , —O—C 1-6 alkyl, —C 1-6 haloalkyl, —C 1-6 alkylene-C(O)N(R A )R B , —C 1-6 alkylene-CN, —C 1-6 alkylene-OH, or —C 1-6 alkylene-O—C 1-6 alkyl; R 5 is: (1) —C (2) —C (3) —C (4) —C (5) heteroaryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (26) as defined above in part (i) of Part B of the definition of R (6) —C (7) aryl, which is optionally substituted with from 1 to 5 substituents each of which is independently any one of the substituents (1) to (21) as defined above in part (i) of Part A of the definition of R and with the proviso that R 5 is —C 1-6 alkyl substituted with R K , when R 1 is other than —C 1-6 alkyl substituted with R J ; R 6 and R 7 are each independently —H or —C 1-6 alkyl; or alternatively R 3 and R 7 together with the carbon atom to which they are attached form (i) a 3- to 8-membered saturated carbocyclic ring which is optionally substituted with from 1 to 6 substituents each of which is independently halogen, —CN, —C 1-6 alkyl, —OH, —O—C 1-6 alkyl, —C 1-6 haloalkyl, or —O—C 1-6 haloalkyl or (ii) a 4- to 7-membered, saturated or mono-unsaturated heterocyclic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O) 2 , and wherein the saturated or mono-unsaturated heterocyclic ring is optionally substituted with from 1 to 4 substituents each of which is independently halogen, —CN, —C 1-6 alkyl, —OH, oxo, —C(O)R A , —CO 2 R A , —S(O)R A , —SR A , —S(O) 2 R A , —CH 2 —CH═CH 2 , —O—C 1-6 alkyl, —C 1-6 haloalkyl, —C 1-6 alkylene-CN, —C 1-6 alkylene-OH, or —C 1-6 alkylene-O—C 1-6 alkyl, each aryl is independently (i) phenyl, (ii) a 9- or 10-membered bicyclic, fused carbocyclic ring system in which at least one ring is aromatic, or (iii) an 11- to 14-membered tricyclic, fused carbocyclic ring system in which at least one ring is aromatic; each heteroaryl is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein each N is optionally in the form of an oxide, or (ii) a 9- or 10-membered bicyclic, fused ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein either one or both of the rings contain one or more of the heteroatoms, at least one ring is aromatic, each N is optionally in the form of an oxide, and each S in a ring which is not aromatic is optionally S(O) or S(O) 2 ; each R A is independently —H or —C 1-6 alkyl; each R B is independently —H or —C 1-6 alkyl; each R C is independently —H or —C 1-6 alkyl; and each R D is independently —H or —C 1-6 alkyl; or alternatively R C and R D together with the N to which they are both attached form a 4- to 7-membered, saturated or mono-unsaturated heterocyclic ring containing the N to which they are both attached and optionally containing 1 or 2 additional heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O) 2 , and wherein the saturated or mono-unsaturated heterocyclic ring is optionally substituted with from 1 to 4 substituents each of which is independently halogen, —CN, —C 1-6 alkyl, —OH, oxo, —C(O)R A , —CO 2 R A , —S(O)R A , —SR A , —S(O) 2 R A , —CH 2 —C 2-6 alkenyl, —O—C 1-6 alkyl, —C 1-6 haloalkyl, —C 1-6 alkylene-CN, —C 1-6 alkylene-OH, or —C 1-6 alkylene-O—C 1-6 alkyl.