Patent ID: 7910587
Filing Date: 2011-03-22
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable, salt, ester or prodrug thereof, wherein R is selected from —(C═O)—R R R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) —C R′ is selected from the group consisting of: (i) —C (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) hydrogen; deuterium; G is selected from —OH, —NHS(O) R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; or (iv) —C X and Y taken together with the carbon atoms to which they are attached form a cyclic moiety which is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl; W is absent, or selected from —O—, —S—, —NH—, —N(Me)—, —C(O)NH—, and —C(O)N(Me)—; Z is selected from the group consisting of: (i) hydrogen; (ii) aryl, substituted aryl; (iii) heteroaryl, substituted heteroaryl; (iv) —C (v) —C (vi) —C (vii) —C W-Z taken together, is —CN, —N m=0, 1, or 2; m′=1 or 2.