Patent ID: 8932583
Filing Date: 2015-01-13
Classification: A61K,A61L,A61P,B33Y,C12N,Y02A

Abstract:
1. A method of regenerating a target tissue of a mammal, comprising contacting a mammalian musculoskeletal tissue with a device comprising a scaffold composition with a bioactive composition being incorporated therein or thereon and a mammalian myogenic passenger cell bound to said scaffold, wherein said bioactive composition comprises an outward migration-inducing factor, wherein the scaffold composition comprises, open, interconnected macropores of 400-500 μm in size, wherein said scaffold composition temporally controls egress of said passenger cell, wherein release of the outward migration-inducing factor from the scaffold composition over time promotes migration of said passenger cell out of the scaffold composition, wherein the outward migration-inducing factor comprises hepatocyte growth factor (HGF) and a member of the fibroblast growth factor (FGF) family that has been demonstrated to have a physiological role in skeletal muscle regeneration, and wherein said passenger cell migrates out of the scaffold and grafts into said target tissue, thereby regenerating or repairing said target tissue.