Patent ID: 8106190
Filing Date: 2012-01-31
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A 2-aminobenzamide derivative or a pharmaceutically acceptable salt thereof, selected from the group consisting of 4-chloro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzamide, 2-(cyclohexylamino)-N-(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-4-(trifluoromethyl)benzamide, 4-chloro-N-[(2R)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-2-{[(1R,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzamide, N-[2-oxo-4-(trifluoromethyl)-2,3-dihydro-1H-indol-6-yl]-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}-4-(trifluoromethyl)benzamide, N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(pyridin-4-ylamino)-4-(trifluoromethyl)benzamide, N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}-4-(trifluoromethyl)benzamide, N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-{[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]amino}-4-(trifluoromethyl)benzamide, 2-{[(1R,2R)-2-(dimethylamino)cyclohexyl]amino}-N-[(2R)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-4-(trifluoromethyl)benzamide, 2-{[(1S,2S)-2-(dimethylamino)cyclohexyl]amino}-N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-4-(trifluoromethyl)benzamide, N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-[(1-isobutylpiperidin-4-yl)amino]-4-(trifluoromethyl)benzamide, N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-{[(3S)-1-pentylpyrrolidin-3-yl]amino}-4-(trifluoromethyl)benzamide, N-(2-oxo-1,2-dihydroquinolin-7-yl)-2-{[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]amino}-4-(trifluoromethyl)benzamide, 2-[(1-butylpiperidin-4-yl)amino]-N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-4-(trifluoromethyl)benzamide, N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-{[(1S,2R)-2-pyrrolidin-1-ylcyclohexyl]amino}-4-(trifluoromethyl)benzamide, 2-{[(1S,2R)-2-pyrrolidin-1-ylcyclohexyl]amino}-N-quinolin-7-yl-4-(trifluoromethyl)benzamide, 2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}-N-quinolin-7-yl-4-(trifluoromethyl)benzamide, and N-[2-oxo-4-(trifluoromethyl)-2,3-dihydro-1H-indol-6-yl]-2-{[(1S,2R)-2-pyrrolidin-1-ylcyclohexyl]amino}-6-(trifluoromethyl)nicotinamide.