Patent ID: 7651845
Filing Date: 2010-01-26
Classification: A61B,A61K,A61M,G16H

Abstract:
1. A run-to-run control method of deriving the optimal dosage of insulin to provide both the basal insulin requirement and the meal-related insulin dosing of an individual having diabetes, comprising: determining an insulin sensitivity matrix for said individual; measuring a postprandial glucose response to at least one meal; and estimating a preprandial dosage of insulin for a subsequent cycle's corresponding meal based on said insulin sensitivity matrix of said individual and measured postprandial glucose response to the meal and preprandial dose of insulin for a current cycle; wherein each element of said insulin sensitivity matrix is a function of one or more parameters affecting insulin needs of an individual pertaining to said individual; wherein said one or more parameters is selected from the group consisting of physical stress, psychological stress, hormonal stress, activity, fitness, and weight; wherein said insulin sensitivity matrix reflects a breadth of output responses in said individual as a function of changes in input; and wherein dosage amount for a subsequent cycle is higher than, lower than, or the same as, dosage amount for a current cycle.