Patent ID: 7851626
Filing Date: 2010-12-14
Classification: A61P,C07D

Abstract:
1. A compound of the formula wherein X 1 and X 2 are halogen, acetylene, cyano, trifluoromethyl or nitro; R R and where R 6 is hydrogen then R R —H -halogen, —CH —CF —OCH —C(CH -cyclopropyl, -cyano, —C(CH —C(CH —C(CH —C(CH —C(CH —C(CH —C(CH —SR (where R is CH —SO and where R 6 is not hydrogen then R R R and R 7 is selected from the group consisting of i) —CH ii) 4-morpholinyl, 1-piperidinyl, 4-thiomorpholinyl, or 4-thiomorpholinyl-1,1-dioxide, iii) —NR iv) a substituted piperazine of the formula wherein R is selected from the group consisting of a) hydrogen, b) lower alkyl, c) CH(CH d) CH(CH e) cyclopentyl, f) —CH g) —CH h) —CH i) —CH j) —CH k) —CH l) —CH m) —CH n) —SO o) —COR p) 4-tetrahydro-2H-thiopyranyl-1,1-dioxide, q) 4-piperidinyl-1-acetyl, r) 4-piperidinyl-1-dimethylcarboxamide, and s) 3-tetrahydro-thiophenyl-1,1-dioxide; v) a substituted oxopiperazine of the formula wherein R is H, —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —CH 2 CH 2 OH, or —CH 2 CH 2 OCH 3 and vi) a substituted piperidine of the formula wherein R is H, COOCH 3 , COOCH 2 CH 3 , CONH 2 , —OH, CH 2 OH, CH 2 CH 2 OH, CH 2 —N(CH 2 CH 3 ) 2 , —CH 2 -(1-piperazinyl), CH 2 -(1-(3-oxopiperazinyl)), NH 2 , NHCOCH 3 , NHCOCH 2 NH 2 , NHCOCH 2 NHCH 3 , NHCOCH 2 N(CH 3 ) 2 , NHCOCH 2 N(CH 2 CH 2 OH) 2 , NHCOCH 2 N(CH 2 CH 2 OCH 3 ) 2 , NHCOCH 2 NHCH 2 CH 2 OH, NHCOCH 2 -(1-(4-acetylpiperazinyl)), NHCOCH 2 -(1-(3-oxopiperazinyl)), NHCOCH 2 -(1-piperidinecarboxamide), NHCOCH 2 —(N,N-diethyl-1-piperidinylcarboxamide), NHCOCH 2 -(1-(3-hydroxypiperidinyl)), NHCOCH 2 -(1-(piperidinyl-4-methanol)), NHCON(CH 3 ) 2 , NHCSNHCH 3 , NHCSNHPh, NHCH 2 CONH 2 , 1-pyrrolidinyl, 1-piperidinyl, 1-(4-methylpiperazinyl), or 4-morpholinyl; and the pharmaceutically acceptable salts and esters thereof.