Patent ID: 6656930
Filing Date: 2003-12-02
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula: wherein each of R1, R4, R5, R6, and R7 is independently selected from the group consisting of hydrido, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxyalkyl, haloalkyl, hydroxyalkyl, carboxy, carboxyalkyl, alkanoyl, alkenyl, and alkynyl; wherein R2, R3 and R8 through R13 is independently selected from the group consisting of hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkenyl, and alkynyl; wherein R2 and R3 may be taken together to form oxo or may be taken together with the carbon to which they are attached to form a saturated or partially unsaturated carbocyclic group having three to eight ring carbons; wherein R4 and R5 may be taken together to form oxo or may be taken together with the carbon to which they are attached to form a saturated or partially unsaturated carbocyclic group having three to eight ring carbons; wherein R8 and R9 may be taken together to form oxo; wherein R10 and R11 may be taken together to form oxo; wherein m is equal to 1-3; n and p are integers from 2-4, with a sum of 6-8; wherein Z is selected from the group consisting of wherein the ring defined by [C]n, Z, [C]p, and N is a ring having 9-11 ring atoms; wherein R14 is selected from the group consisting of hydrido, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, alkanoyl, aroyl, aminoalkyl, monalkylaminoalkyl, and dialkylaminoalkyl; wherein each of R15 and R16 is independently selected from the group consisting of hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aralkoxy, aryloxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, halo, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl and alkanoyl; wherein each of R17 and R18 is independently selected from the group consisting of hydrido, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, alkoxyalkyl, haloalkyl, hydroxyalkyl, halo, cyano, carboxy, carboxyalkyl and alkanoyl; wherein A is selected from the group consisting of aryl, heteroaryl, aryloxy, heteroaryloxy, aralkoxy, heteroaralkoxy, arylamino, heteroarylamino, aralkylamino, heteroaralkylamino, arylthio, heteroarylthio, aralkylthio, and heteroaralkylthio; wherein A can be further substituted with one or more substituents independently selected from the group consisting of hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, halo, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkenyl, and alkynyl; or a pharmaceutically acceptable salt thereof.