Patent ID: 6180645
Filing Date: 2001-01-30
Classification: A61P,C07D

Abstract:
A method for treating epilepsy in a warm-blooded animal which comprises administering to said animal a therapeutically effective amount of a pharmaceutical composition comprising a compound of formula I ##STR183##wherein:A represents thieno or benzo whereinif A is benzo, m is 2 or 3; or if A thieno m is zero;R.sup.2 independently of each other denote hydroxy, (C.sub.1-4)alkoxy, benzyloxy, F, Cl, Br, I, (C.sub.1-4)alkyl, methanesulphonyloxy or methanesulphonamido, or two adjacent substituents R.sup.2 may together represent --O--CH.sub.2 --O-- or --O--CH.sub.2 --CH.sub.2 --O--;R.sup.1 denotes thienyl or the group ##STR184##whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.3 and R.sup.4 independently represent:(a) hydrogen,(b) branched or unbranched C.sub.3-6 alkenyl,(c) branched or unbranched C.sub.3-6 alkynyl,(d) branched or unbranched C.sub.1-12 alkyl which may be optionally mono- or di-substituted by:hydroxy,(C.sub.1-4)alkoxy,di(C.sub.1-4)alkylamino,furyl,pyridyl,pyrrolidinyl or N-methylpyrrolidinyl,morpholinyl,indolyl,nitrilo,thienyl,adamantyl,cyclohexyl,naphthyloxy,phenoxy or phenyl wherein the phenyl group may be optionally mono-, di- or trisubstituted by hydroxy, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, benzyloxy, F, Cl, Br, I, CF.sub.3, N.sub.3, adamantyl, --SO.sub.2 NH.sub.2, --NHCOCH.sub.3, --NHSO.sub.2 CH.sub.3, CH.sub.3 SO.sub.2 O--, or by the bridge --O--CH.sub.2 --O-- or by two unsubstituted phenyl groups; orR.sup.3 represents hydrogen and R.sup.4 represents phenyl optionally mono-, di- or trisubstituted by hydroxy, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, benzyloxy, F, Cl, Br, I, CF.sub.3, N.sub.3, adamantyl, --SO.sub.2 NH.sub.2, --NHCOCH.sub.3, --NHSO.sub.2 CH.sub.3, CH.sub.3 SO.sub.2 O--, or by the bridge --O--CH.sub.2 --O--; cyclohexyl, pyridyl or N-benzylpiperidyl; orR.sup.3 and R.sup.4 together with the nitrogen atom to which they are bound represent pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl or piperazinyl, whilst the piperazinyl ring may optionally be N-substituted by methyl, unsubstituted phenyl, mono- or di (C.sub.1-4)alkoxyphenyl, cyano-substituted phenyl, pyrimidinyl, phenyl (C.sub.1-4)alkyl, (C.sub.1-4)alkylphenyl or ##STR185##or physiologically acceptable acids or salts thereof.