Patent ID: 6420370
Filing Date: 2002-07-16
Classification: A61P,C07D

Abstract:
A compound, and pharmaceutically acceptable salts thereof, having the formula wherein X and Y are the same or different and are selected from the group consisting of OH, NH2, H and CH3; wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is selected from the group consisting of a single bond and a double bond, L and M are carbon when the bond is a double bond, and L and M are CH when the bond is a single bond; wherein Z4, Z5 and Z6 are different and are selected from the group consisting of R4, R5 and wherein each of R4, R5 and Aâ€”B are used once; wherein A is selected from the group consisting of CH, sulfur and zero; wherein B is selected from the group consisting of sulfur, sulfoxide, sulfone, nitrogen, oxygen, CH, Nâ€”CH2, CH2â€”N, CH2â€”CH2, and zero; wherein R1 is selected from the group consisting of hydrogen, a lower alkyl group, a nitroso group, a formyl group and zero, and R1 is zero when B is zero, oxygen, sulfur, sulfoxide or sulfone; wherein R2 is selected from the group consisting of a lower alkyl group, p-aroyl-L-glutamate, an aryl group, a benzyl group, a heteroaryl group, an alkylaryl group, an alkylbenzyl group, an alkylheteroaryl group, a substituted aryl group, a substituted heteroaryl group, a substituted alaylaxl group, a substituted alkylbenzyl group, a substituted alkylheteroaryl group, a diaryl group, a bicyclic heteroaryl group, a tiaryl group, a tricyclic heteroaryl group, an alkyldiaryl group, a bicyclic alkylheteroaryl group, an alicyclic hydrocarbon group, an alkyltriaryl group, a tricyclic alkylheteroaryl group, a substituted diaryl group, a substituted bicyclic heteroaryl group, a substituted triaryl group, a substituted tricyclic heteroaryl group, and each substituent of the substituted aryl or heteroaryl group, diaryl or bicyclic heteroaryl group, triaryl or tricyclic heteroaryl group, or the substituted alkylaryl, alkylbenzyl or alkylheteroaryl group, alkyldiaryl or bicyclic alkylheteroaryl group, or alkyltriaryl or tricyclic alkylheteroaryl group is the same or different and is selected from the group consisting of a lower alkyl group, an alkyl group, an alkoxy, an alkoxyaryloxy group, a halogen and zero; wherein R3 is selected from the group consisting of hydrogen, a lower alkyl group and zero, and R3 is zero when A is zero; wherein R4 is independently selected from the group consisting of hydrogen and a lower alkyl group; wherein R5 is independently selected from the group consisting of hydrogen and a lower alkyl group; and wherein each lower alkyl group is independently selected from the group consisting of lower alkyl groups having from about 1 to 6 carbons; but, when X=OH; Y=H, Z4=H, Z5=H, â€ƒA=zero and B=oxygen, R2 is not a methyl or ethyl group; when X=OH, Y=NH2, Z4=H, Z5=H, â€ƒand A(R3) and B(R1) together are CH2â€”CH2, R2 is not p-benzoyl-L-glutamate; and when X=NH2, Y=NH2, Z4=H, Z5=H, â€ƒA=CH, R3=H, B=CH2â€”CH2, and R1=zero, R2 is not triphenyl-L-glutarate.