Patent ID: 7605275
Filing Date: 2009-10-20
Classification: A61P,C07C,C07D,C07F,Y02P

Abstract:
1. A process for preparing Compound 1: said process comprising the steps of: (a) cyclizing Compound 2 in a first solvent at an elevated temperature where R to produce a first mixture of exo isomers said isomers having a trans-[5,6]-ring junction: and endo isomers: (b) epimerizing said trans-[5,6]-ring-junction in Compound 29 by treating said first mixture with a first base to produce a second mixture comprising cis-[5,6]-ring-junction-nitro-α isomer and cis-[5,6]-ring-junction-nitro-β isomer of Compound 30: and (c) treating said second mixture with a second solvent, causing said α-isomer of Compound 30 to precipitate to produce Compound 1.