Patent ID: 6329519
Filing Date: 2001-12-11
Classification: C07H,Y02P

Abstract:
A compound of formula ##STR33##where B.sup.1 is a radical of a nucleoside base, R.sup.1 is hydrogen or a hydroxy-protecting group, R.sup.2 is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R.sup.3 is an unsubstituted or substituted C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.4 to C.sub.10 cycloalkylalkyl, C.sub.6 to C.sub.10 aryl or C.sub.7 to C.sub.13 aralkyl group, and Z is halogen or a group of formula ##STR34##where R.sup.4 and R.sup.5 are each independently an unsubstituted or substituted C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.4 to C.sub.10 cycloalkylalkyl, C.sub.6 to C.sub.10 aryl or C.sub.7 to C.sub.13 aralkyl group, or R.sup.4 is said group and R.sup.5 is hydrogen, or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formulaNuc--O-- IIIwhere Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom.