Patent ID: 6197943
Filing Date: 2001-03-06
Classification: A61P,C08B

Abstract:
A process for the preparation of glycosaminoglycans having an anti-Xa activity in vitro from 100 to 150 U/mg, containing at least 20% of iduronic units sulfated in position 2 and not sulfated in position 3 and at least 30% of sulfaminoglucosaminic units sulfated in position 3 and in position 6, and having a sulfates/carboxyls molar ratio ranging from 2.0 to 3.5, starting from glycosaminoglycans in which the glucosamine units are completely N-desulfated and totally 6-O sulfated and the uronic units are sulfated from 50% to 100% in the positions 2 and 3, wherein said process comprises:a) preparation of a salt of an organic base of the starting glycosaminoglycans;b) partial solvolytic desulfation of the salts of the step a) by treatment with an aprotic polar solvent containing methanol or water at a temperature ranging from 50 to 80.degree. C. for a time ranging from 5 to 480 minutes;c) N-resulfation of the partially desulfated product of step b);d) optional 6-0 resulfation of the product of step c).