Patent ID: 6448256
Filing Date: 2002-09-10
Classification: A61P,C07D

Abstract:
A compound having the formula: wherein R1 is â€”(CH2)aâ€”(CHOH)bâ€”(CH2)câ€”Oâ€”C(&boxH;O)â€”(CH2)d-CHR5â€”R6, wherein a is 1-4; b is 0 or 1; c is 1-5; d is 0-4; n is 0 or 1; R5 is the side chain of a â€”COOH, â€”COOâˆ’M+, or â€”NH2; each of R2 and R3 is, independently, linear C1-6 alkyl, branched C3-6 alkyl, linear C1-6 haloalkyl, branched C3-6 haloalkyl, halo, or R2 and R3 together are a bivalent moiety having the formula â€”(CH2)3â€”; M+ is a pharmaceutically acceptable counter-ion; and R4 is &boxH;O or â€”NH2, or a pharmaceutically acceptable salt thereof.