Patent ID: 6294563
Filing Date: 2001-09-25
Classification: A61K,Y10S

Abstract:
A method of treating a mammal suffering from glaucoma or ocular hypertension, comprising administering to the mammal a therapeutically effective amount of a prostaglandin and a therapeutically effective amount of an alpha adrenergic agent of formula (I) ##STR13##wherein each Y is independently selected from the group consisting of N, N--CH3, O, S and C--R.sub.1 ; R.sub.1 is hydrogen, lower alkyl or oxo; R.sub.2, R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl and lower alkenyl; n is an integer from 1 to 3; and a broken line beside a solid line indicates either a single or a double bond, provided that two double bonds are not on the same carbon in the case when n=1, and their pharmaceutically acceptable salts and esters as appropriate wherein said method provides neuroprotection.