Patent ID: 6822098
Filing Date: 2004-11-23
Classification: A61K,A61P,C07D

Abstract:
An amide derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein:X1 to X4 each independently represents C; Y represents NH; R1 represents a C1 to C6 alkyl group; R2 represents (a) a C1 to C10 alkyl group, or (b) an aryl-C1 to C10 alkyl group, a heteroaryl-C1 to C10 alkyl group, or a cycloalkyl-C1 to C10 alkyl group, provided that the C1 to C10 alkyl group may be any carbon-carbon bond of the C1 to C10 alkyl group may be inserted by â€”Oâ€”, â€”NR8â€”, or â€”S(O)nâ€”, wherein R8 represents H or a C1 to C6 alkyl group, and n is 0, 1 or 2, and that the aryl, heteroaryl and cycloalkyl may each be substituted with from one to three of halogen, C1 to C6 alkyl, C1 to C6 alkyl-Oâ€”, nitro, cyano, amino, hydroxycarbonyl, C1 to C6 alkyl-NHâ€”, or di-C1 to C6 alkyl=Nâ€”; R3 represents H, a C1 to C6 alkyl group, an aryl-C1 to C6 alkyl group, a heteroaryl-C1 to C6 alkyl group, a cycloalkyl-C1 to C6 alkyl group, an aryl group, a heteroaryl group, or a cycloalkyl group, provided that the aryl, heteroaryl, and cycloalkyl group may each be substituted with from one to three of halogen, C1 to C6 alkyl, C1 to C6 alkyl-Oâ€”, nitro, cyano, amino, hydroxycarbonyl, C1 to C6 alkyl-NHâ€”, or di-C1 to C6 alkyl=Nâ€”; and R4 to R7 may be the same or different and each represents H, a halogen, a nitro group, a cyano group, an amino group, a hydroxycarbonyl group, a C1 to C6 alkyl group, a C1 to C6 alkyl-Oâ€” group, a C1 to C6 alkyl-NH group, or a di-C1 to C6 alkyl=Nâ€” group, provided that R3 and R4 may be taken together to form a linear or branched C1 to C8 alkylene which may be inserted by N, O or S.