Patent ID: 7563586
Filing Date: 2009-07-21
Classification: A61P,G01N

Abstract:
1. A method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises: (a) providing a cell expressing (i) a VGSC comprising amino acids 74 to 103 of SEQ ID NO: 6 and (ii) a p11 peptide comprising amino acids 33 to 77 of SEQ ID NO: 8, wherein at least said p11 peptide is expressed from a vector introduced into the cell; (b) bringing into contact said cell and a test compound under in vitro conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound; and (c) measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC.