Patent ID: 6331562
Filing Date: 2001-12-18
Classification: A61P,C07D

Abstract:
A compound having the structure: ##STR75##or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof,wherein:n is 0, 1, 2, 3 or 4;p is 0;R.sub.1 is an unsubstituted or substituted C.sub.6-12 aryl, C.sub.7-12 arylalky, C.sub.3-12 heterocycle or C.sub.4-16 heterocyclealkyl;R.sub.2 is NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are independently hydrogen, C.sub.1-8 alkyl, C.sub.6-12 aryl, or heterocycle, and wherein R.sub.a and R.sub.b are optionally substituted with up to three substituents independently selected from C.sub.1-6 allyl, halogen, C.sub.1-6 alkoxy, hydroxy and carboxyl;or R.sub.2 is a heterocyclic ring of the following structure: ##STR76##whereinm.sub.1 and m.sub.2 are independently 0, 1 or 2, and both m.sub.1 and m.sub.2 are not 0,A is CH.sub.2, O, S or NH,Z represents 0, 1, 2 or 3 heterocyclic ring substituents selected from halogen, C.sub.1-8 alkyl, C.sub.6-12 aryl, C.sub.7-12 arylalky, C.sub.3-12 heterocycle, or C.sub.4-6 heterocyclealkyl,and wherein any hydrogen atom on the heterocyclic ring may, taken together with a hydrogen atom on an adjacent atom of the heterocyclic ring, form a double bond;R.sub.3 is hydrogenate, C(.dbd.O)R.sub.4, C(.dbd.O)OR.sub.4, CONHR.sub.4, CONR.sub.4 R.sub.5, or SO.sub.2 NR.sub.5 R.sub.5 ;R.sub.4 and R.sub.5 are independently C.sub.1-8 alkyl, C.sub.6-12 aryl, C.sub.7-12 aralkyl, or a five- or six-membered heterocycle containing up to two heteroatoms selected from O, NR.sub.6 and S(O).sub.q, wherein each of the above groups are optionally substituted with one to three substituents independently selected from R.sub.7 and q is 0, 1 or 2;R.sub.6 is hydrogen or C.sub.1-4 alkyl; andR.sub.7 is hydrogen, halogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy, C.sub.1-4 thio, C.sub.1-4 alkylsulfinyl, C.sub.1-4 alkylsulfonyl, (hydroxy)C.sub.1-4 alkyl, C.sub.6-12 aryl, C.sub.7-12 aralkyl, COOH, CN, CONHOR.sub.8, SO.sub.2 NHR.sub.8, NH.sub.2, C.sub.1-4 alkylamino, C.sub.1-4 dialkylamino, NHSO.sub.2 R.sub.8, NO.sub.2, or a five- or six-membered heterocycle, where each occurrence of R.sub.8 is independently C.sub.1-6 alkyl.