Patent ID: 7641914
Filing Date: 2010-01-05
Classification: A61K,C07D,C07J

Abstract:
1. A composition comprising at least one acid-sensitive compound, or a salt thereof, wherein the at least one acid-sensitive compound, or a salt thereof comprises (a) a cyclic ortho-ester and (b) at least one hydrophilic substituent or at least one hydrophobic substituent; wherein the at least one hydrophilic substituent is chosen from polyalkylene glycols, polyalkylene imine, monosaccharides, and polysaccharides; and wherein the at least one hydrophobic substituent is chosen from (i) steroid derivatives chosen from sterols, steroids, steroid hormones, cholesterol, cholestanol, 3-α-5-cyclo-5-α-cholestan-6-β-ol, cholic acid, cholesteryl formate, cholestanyl formate, 3α,5-cyclo-5α-cholestan-6β-yl formate, cholesterylamine, 6-(1,5-dimethylhexyl)-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-10-ylamine, cholestanylamine, and dexamethasone; and (ii) hydrophobic dendrimers; and the composition comprises at least one pharmaceutically acceptable vehicle.