Patent ID: 6344470
Filing Date: 2002-02-05
Classification: A61P,C07D

Abstract:
A method for the treatment of diseases requiring modulation of the action of corticotropin releasing factor which comprises administering to a patient in need of such treatment an effective amount of a compound of formula: in whichR1 and R2, which are identical or different, each represent independently a halogen atom; a (C1-C5)hydroxyalkyl; a (C1-C5)alkyl; an aralkyl in which the aryl part is a (C6-C8) and the alkyl part is a (C1-C4); a (C1-C5)alkoxy; a trifluoromethyl group; a nitro group; a nitrile group; a group â€”SR in which R represents hydrogen, a (C1-C5)alkyl or an aralkyl in which the aryl part is a (C6-C8) and the alkyl part is a (C1-C4); a group â€”Sâ€”COâ€”Ro in which Ro represents a (C1-C5)alkyl radical or an aralkyl in which the aryl part is a (C6-C8) and the alkyl part is a (C1-C4); a group â€”COORa in which Ra represents hydrogen or a (C1-C5)alkyl; a group â€”CONRaRb with Ra and Rb as defined above for Ra; a group â€”NRaRb with Ra and Rb as defined above for Ra; a group â€”CONRcRd or â€”NRcRd in which Rc and Rd constitute, with the nitrogen atom to which they are attached, a 5- to 7-membered heterocycle; or a group â€”NHCOâ€”NRaRb with Ra and Rb as defined above for Ra; R3 represents hydrogen or is as defined above for R1 and R2; R4 represents a (C1-C5)alkyl; a hydroxymethyl group; a formyl group; or a halogen atom; R5 represents a (C1-C5)alkyl; a cycloalklyalkyl group in which the cycloalkyl is a (C3-C7) and the alkyl is a (C1-C5); an alkenyl of 3 to 6 carbon atoms; a (C1-C5)hydroxyalkyl; an alkylcarbonyloxyalkyl group in which the alkyls are a (C1-C5); or an alkynyl group of 3 to 6 carbon atoms; R6 represents a phenyl substituted with one or more substituents Z as defined below; a monocyclic heteroaromatic C5-C7 group substituted with one or more radicals Z as defined below; or a bicyclic C9-C10 group consisting of an aromatic monocycle optionally comprising one or more heteroatoms selected from O, N and S, condensed with a cycloalkyl group optionally comprising in the ring one or more heteroatoms selected from O, N and S, which bicyclic group is substituted with one or more substituents Z as defined below and which is attched to the nitrogen by the ring of an aromatic nature, it being understood that R6 does not represent a substituted indan and that the substituent Z represents a radical selected from: a halogen atom, a nitro group, a hydroxyl group, a trifluoromethyl group, a (C1-C5)alkyl, a (C1-C5)thioalkyl, a group â€”NRaRb with Ra and Rb as defined above for Ra, a (C1-C5)hydroxyalkyl, a (C1-C5)alkoxy, a trifluoromethyloxy group, an alkoxyalkyl in which the alkyls are a (C1-C5), a group â€”COORa with Ra as defined above, a group â€”CONRaRb with Ra and Rb as defined above for Ra, a carboxy(C1-C5)alkyl, an alkoxycarbonylalkyl in which the alkyls are a (C1-C5), a (C1-C5)alkylcarbonyl, an alkylcarbonylalkyl in which the alkyls are a (C1-C5), a morpholinocarbonyl or morpholinocarbonyl(C1-C5)alkyl group, or a group â€”NRaCOORb with Ra and Rb as defined above, a group â€”NHCORe in which Re represents a (C1-C5)alkyl, a cycloalkylcarbonyl in which the cycloalkyl is a (C3-C6), a cycloalkylalkylcarbonyl in which the cycloalkyl is a (C3-C6) and the alkyl a (C1-C3), a benzoyl, a phenyl which is unsubstituted or substituted with a (C1-C5)alkyl, with a (C1-C5)alkoxy, with a halogen atom, with a nitro group, with a hydroxyl group or with a trifluoromethyl group; their stereoisomers, their addition salts, their hydrates and/or their solvates.