Patent ID: 6090813
Filing Date: 2000-07-18
Classification: A61K,A61P,C07D

Abstract:
A method for treating a disease or medical condition mediated at least in part by the inhibition of oxido-squaline cyclase, said method comprising administering to a warm blooded animal in need thereof an oxido-squaline cyclase inhibiting effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof ##STR21## wherein: G is selected from CH and N;T.sup.1 is selected from CH and N;R.sup.1 is hydrogen, amino, halogeno, cyano, (1-6C)alkyl or (1-6C)alkoxy;m is 1 or 2;A is selected from a direct bond and (1-4C)alkylene;T.sup.2 is selected from CH and N;T.sup.3 is selected from CH and N, provided that T.sup.2 and T.sup.3 are not both CH;a and b are independently selected from 2 and 3;c and d are independently selected from 1 and 2;wherein the heterocyclic ring containing T.sup.1 and the heterocyclic ring containing T.sup.2 may, independently, be optionally substituted by one or more substituents selected from (1-6C)alkyl, (1-6C)alkoxy, phenyl(1-4C)alkyl, halogeno and (1-6C)alkoxycarbonyl;X is selected from oxy, thio, sulphinyl, sulphonyl, carbonyl, carbonylamino, N-di-(1-6C)alkylcarbonylamino, sulphonamido, methylene, (1-4C)alkylmethylene and di-(1-6C)alkylmethylene, and when T.sup.2 is CH, X may also be selected from aminosulphonyl and oxycarbonyl;Q is selected from (5-7C)cycloalkyl, a heterocyclic moiety containing up to 4 heteroatoms selected from nitrogen, oxygen and sulphur; phenyl, naphthyl, phenyl(1-4C)alkyl and phenyl(2-6C)alkenyl, and wherein the last three groups may optionally bear a phenyl substituent; and wherein Q may be unsubstituted or may bear one or more substituents selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkyl, (1-4C)alkylenedioxy, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, N-(1-6C)alkylcarbamoyl, di-N[(1-6C)alkyl]carbamoyl, (1-6C)alkanoylamino, (1-6C)alkoxycarbonyl, (1-6C)alkylthio, (1-6C)alkylsulphinyl, (1-6C)alkylsulphonyl, halogeno(1-6C)alkyl, (1-6C)alkanoyl, tetrazolyl and a heteroaryl group comprising a 5- or 6-membered monocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen and sulphur.