Patent ID: 8394378
Filing Date: 2013-03-12
Classification: A61K,C07K

Abstract:
1. An isolated monoclonal antibody or fragment thereof that binds human collagen II, selected from the group consisting of: i. a VH region and a VL region, wherein the VH region comprises the HCDRI, HCDR2, and HCDR3 sequences as shown in SEQ ID NO: 11, 17, and 30, respectively, and the VL region comprises the LCDRI, LCDR2, and LCDR3 sequences as shown in SEQ ID NO: 34, 42, and 47, respectively, ii. a VH region and a VL region, wherein the VH region comprises the HCDRI, HCDR2, and HCDR3 sequences as shown in SEQ ID NO: 9, 15, and 28, respectively, and the VL region comprises the LCDRI, LCDR2, and LCDR3 sequences as shown in SEQ ID NO:s 39, 42, and 53, respectively, and iii. a VH region and a VL region, wherein the VH region comprises the HCDRI, HCDR2, and HCDR3 sequences as shown in SEQ ID NO: 13, 19, and 32, repectively, and the VL region comprises the LCDRI, LCDR2, and LCDR3 sequences as shown in SEQ ID NO: 41, 42, and 55, respectively.