Patent ID: 8524868
Filing Date: 2013-09-03
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A multimer of purified monomeric polypeptides, wherein said multimer is formed by 2-180 purified monomeric polypeptides via self-aggregation, and each said purified monomeric polypeptide is selected from the group consisting of (a) a fragment of SEQ ID No. 1 of hepatitis E virus ORF 2 wherein the amino terminus starts from between amino acid residues 370 and 469, and the carboxyl terminus ends from between amino add residues 601 and 628, wherein the fragment of SEQ ID No. 1 is selected from the group consisting of (b) a polypeptide having the amino acid sequence of amino acid residues X to 603 from SEQ ID No. 1 with Met added at the N-terminus and a modified C-terminus, wherein the modified C-terminus is an addition, in the 5′ to 3′ direction, of amino acid sequence -Pro-Pro-Arg at amino acid residue 603, Pro, on its 3′ end and wherein