Patent ID: 7285543
Filing Date: 2007-10-23
Classification: A61P,C07F

Abstract:
1. A method of preventing type II diabetes in animals comprising administering to animals at risk of developing type II diabetes a pharmaceutically effective amount of a compound of formula 1: wherein A is selected from the group consisting of —NR E is selected from the group consisting of —H, halo, lower alkylthio, lower perhaloalkyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, —CN, and —NR X, C, N together with Y form a substituted or unsubstituted heterocyclic group of 4 to about 20 carbon atoms and from 1 to 5 heteroatoms, said heteroatoms being independently selected from N, O, P or S and wherein said substituted heterocyclic group contains from one to four substituents independently selected from lower alkyl, lower aryl, lower aralkyl, lower alicyclic hydroxy, lower alkoxy, lower aryloxy, perhaloalkoxy, aralkoxy, heteroaryl, heteroaryloxy, heteroarylalkyl, heteroaralkoxy, azido, amino, guanidino, halogen, lower alkylthio, —C(O)OR, wherein R is a substituted or unsubstituted alkyl, aryl, aralkyl or alicyclic group, carboxyl, carboxamido, nitro, acyloxy, alkylamino, aminoalkyl, alkylaminoaryl, alkylaryl, alkylaminoalkyl, alkoxyaryl, arylamino, aralkylamino, phosphonate, sulfonate, carboxamidoalkylaryl, carboxamidoaryl, hydroxyalkyl, haloalkyl, alkylaminoalkylcarboxy, aminocarboxamidoalkyl, cyano, lower alkoxyalkyl, and lower perhaloalkyl; R wherein V and W are independently selected from the group consisting of hydrogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl, 1-alkenyl, 1-alkynyl, and —R together V and Z are connected via a chain of 3-5 atoms, only one of which can be a heteroatom, to form part of a cyclic group substituted with hydroxy, acyloxy, alkoxycarboxy, or aryloxycarboxy attached to a carbon atom that is three atoms from an oxygen attached to the phosphorus; or together V and W are connected via a chain of 3 carbon atoms to form part of a cyclic group substituted with hydroxy, acyloxy, alkoxycarboxy, alkylthiocarboxy, hydroxymethyl, or aryloxycarboxy attached to a carbon atom that is three atoms from an oxygen attached to the phosphorus; Z is selected from the group consisting of —CH with the provisos that: R R R R R R R R R R pharmaceutically acceptable prodrugs and salts thereof.