Patent ID: 8629288
Filing Date: 2014-01-14
Classification: C07C,C07D

Abstract:
1. A process for preparing a 1-alkyl-3-haloalkylpyrazole-4-carboxylic acid derivative of formula (I) in which R R Y is (C═O)OR comprising at least one of the reaction sequences consisting of steps (A) and (D), (B) and (D) or (C) and (D) below: (A) reaction of a 2-acylated or 2-iminoalkylated acrylic acid derivative of formula (II), in which Z is selected from the group consisting of O, S and N A is a leaving group NR with an N-alkylhydrazone of formula (III) in which R (B) acylation of an acrylic acid hydrazone of formula (VI); with an acyl halide of formula (X), where X′ is selected from the group consisting of F, Cl, Br and I: (C) iminoalkylation of an acrylic acid hydrazone of the formula (VI) above with an α,α-dihaloamine of formula (XI), where X′ is selected from the group consisting of F, Cl, Br and I: (D) cyclization of an intermediate obtained in step (A), (B) or (C) to give the 3-haloalkylpyrazole-4-carboxylic acid derivative of the formula (I).