Patent ID: 6682916
Filing Date: 2004-01-27
Classification: C07B,C07C,C12P

Abstract:
A process for preparing an optically active chioropropanediol derivative represented by the formula (4); wherein R2 is an alkyl group having 1 to 10 carbon atoms, an aryl group which may be substituted with a group having 1 to 15 carbon atoms, an aralkyl group which may be substituted with a group having 1 to 15 carbon atoms, an alkylsulfonyl group having 1 to 10 carbon atoms, an arylsulfonyl group which may be substituted with a group having 1 to 15 carbon atoms, an alkylcarbonyl group having 1 to 10 carbon atoms or an arylcarbonyl group which may be substituted with a group having 1 to 15 carbon atoms, which comprises allowing a chiorohydroxyacetone derivative represented by the formula (3); wherein R2 is the same as the defined above, obtained by allowing the chloropropanediol derivative represented by the formula (2); wherein R2 is the same as the defined above, to react with a nitroxyl compound represented by the formula (7); wherein each of R4, R5, R6 and R7 is an alkyl group which may be the same or different, R8 is hydrogen atom or electron-releasing group, in the presence of an oxidizing agent, to be stereospecifically reduced in the presence of an enzyme source having an activity to reduce it stereospecifically.