Patent ID: 7655624
Filing Date: 2010-02-02
Classification: A61K,A61P

Abstract:
1. A compound of formula I wherein B is a bioactive, integrin-binding molecule which is, (1) cyclo-(Arg-Gly-Asp-Z (2) wherein (3) Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (vi), (SEQ. ID. NO. 1); (4) Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (vii), (SEQ. ID. NO. 2); (5) Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (viii), (SEQ. ID. NO. 3); (6) Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (ix), (SEQ. ID. NO. 4); (7) Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (x), (SEQ. ID. NO. 5); or (8) Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (xi), (SEQ. ID. NO. 6); Q is absent or is an organic spacer molecule which is  or a combination thereof, wherein m in each case independently of one another is 1-20, x is 1-12, y is 1-50, and z is 1-12, and X wherein n, in each case independently of one another, is 0, 1, 2 or 3, and wherein a free amino group in group B is linked in a peptide-like manner to a free carboxyl group in group Q or in group X or a free amino group of the group Q is linked in a peptide-like manner to a free carboxyl group of the radical X