Patent ID: 6150358
Filing Date: 2000-11-21
Classification: A61P,C07D

Abstract:
A compound selected from those of the formula (I): ##STR16## wherein: Ra represents linear or branched (C.sub.1 -C.sub.8)alkylene,Rb represents a single bond, or linear or branched (C.sub.1 -C.sub.6)alkylene,Z represents:thiocarbamate ##STR17## wherein the oxygen is bonded to Ra, and R.sub.1 represents a group selected from hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, aryl, and aryl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched, orthe thioamide ##STR18## wherein thiocarbonyl is bonded to Ra, and R.sub.1 is as defined hereinbefore,T represents a group ##STR19## wherein R.sub.2 and R.sub.3, which may be identical or different, each independently of the other represents a group selected from hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, cycloalkyl, cycloalkyl-(C.sub.1 -C.sub.6) alkyl in which alkyl is linear or branched, heterocycloalkyl, heterocycloalkyl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched, aryl, aryl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched, heteroaryl, heteroaryl-(C.sub.1 C.sub.6)alkyl in which alkyl is linear or branched, and amino-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched (amino being optionally substituted by one or two identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)alkyl, aryl, and aryl-(C.sub.1 -C.sub.6)alkyl in which alkyl is linear or branched),its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, it being understood that:""cycloalkyl"" means a mono- or bi-cyclic, saturated or unsaturated group having 3 to 8 carbon atoms, each of those groups being optionally substituted by one or more identical or different groups selected from halogen, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, and amino (amino itself optionally substituted by one or two, identical or different linear or branched (C.sub.1 -C.sub.6)alkyl),""heterocycloalkyl"" means cycloalkyl in which one or two carbon atoms have been replaced by a heteroatom selected, identically or differently, from nitrogen, oxygen, and sulphur,""aryl"" means phenyl, naphthyl, indenyl, tetrahydronaphthyl, dihydronaphthyl, or indanyl, each of those groups being optionally substituted by one or more, identical or different, groups selected from halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, amino, mono- or di-(C.sub.1 -C.sub.6)alkyl-amino in which alkyl moiety is linear or branched, carboxy, and linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl,""heteroaryl"" means aryl in which one or two carbon atoms have been replaced by a heteroatom selected, identically or differently, from oxygen, nitrogen, and sulphur.