Patent ID: 8679537
Filing Date: 2014-03-25
Classification: A61K,C08L,C09J

Abstract:
1. A method for sealing an orifice in tissue in the body of a living animal comprising: applying to the orifice (a) a first aqueous solution comprising from about 5% to about 40% by weight of a polysaccharide that has been oxidized to provide an oxidized polysaccharide that contains aldehyde groups, said polysaccharide having a molecular weight of about 1,000 to about 1,000,000 Daltons, and said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons, such that the oxidized polysaccharide has on average more than two aldehyde groups, followed by (b) a second aqueous solution comprising from about 5% to about 40% by weight of poly(vinyl alcohol) that has been derivatized to provide a derivatized poly(vinyl alcohol) that contains acetoacetate groups, said poly(vinyl alcohol) having a molecular weight of less than or equal to about 100,000 Daltons, and said derivatized poly(vinyl alcohol) having an equivalent weight per acetoacetate group of about 100 to about 2000 Daltons, such that the derivatized poly(vinyl alcohol) has on average more than two acetoacetate groups, or applying the second aqueous solution followed by the first aqueous solution and mixing the first and second aqueous solutions on the orifice, or premixing the first and second aqueous solutions and applying the resulting mixture to the orifice before the resulting mixture completely cures, thereby forming on said orifice a resorbable adhesive hydrogel, and allowing the hydrogel to remain on said orifice until said hydrogel is resorbed; provided that: wherein the polysaccharide is selected from the group consisting of dextran, chitin, starch, agar, cellulose and hyaluronic acid.