Patent ID: 6420386
Filing Date: 2002-07-16
Classification: A61P,C07F

Abstract:
A compound selected from those of formula (I): wherein:R1 represents halogen or trifluoromethyl, R2 represents aryl or heteroaryl, R3 and R4, which may be identical or different, represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl or a group (wherein R5 and R6, which may be identical or different, represent hydrogen or alkyl, cycloalkyl or aryl), it being understood that:â€œalkylâ€  is understood to mean linear or branched alkyl containing 1 to 6 carbon atoms, â€œcycloalkylâ€  is understood to mean cyclic alkyl containing 3 to 8 carbon atoms, â€œarylâ€  is understood to mean the groups phenyl, naphthyl or biphenyl, it being possible for those groups to be unsubstituted or substituted by 1 to 3 groups selected from alkyl, cycloalkyl, alkoxy, polyhaloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, SO2NR7R8 (wherein R7 and R8, which may be identical or different, represent hydrogen or alkyl, cycloalkyl or aryl) and halogen atoms, â€œheteroarylâ€  is understood to mean a mono-cyclic aromatic group containing 5 to 6 ring atoms and containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, it being possible for the heteroaryl to be attached to the benzene ring that carries it by carbon or by nitrogen when it has one, and for it to be unsubstituted or substituted by 1 to 3 groups selected from alkyl, alkoxy, polyhaloalkyl, cyano, nitro, amino (unsubstituted or substituted by 1 or 2 alkyl groups), SO2NR7R8 (wherein R7 and R8 are as defined hereinbefore) and halogen atoms, its enantiomers and diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid or base.