Patent ID: 6335337
Filing Date: 2002-01-01
Classification: A61P,C07D,Y02P

Abstract:
Compounds of general formula (I): in which:R1 is chosen from hydrogen, a C1-C4 alkyl group and a phenyl (C1-C4 alkyl) group; R2 is chosen from hydrogen, a hydroxyl group and a protecting group for the amidino group selected from the group consisting of ethoxycarbonyl, benzyloxycarbonyl, p-nitrobenzyloxycarbonyl and tert-butoxycarbonyl; R3 is chosen from the groups of formula: â€”NHâ€”COâ€”R6, and NHSO2R7 R6 being chosen from C1-C4 alkoxy, C3-C7 cycloalkoxy, benzyloxy, methoxyphenyl, dimethoxyphenyl, benzodioxolyl and benzodioxanyl groups and in the group of formula: â€”NHâ€”SO2â€”R7, R7 being chosen from: C1-C5 alkyl groups optionally substituted with one or more groups chosen from halogens, hydroxyl groups and the trifluoromethyl group; mono- or bicyclic C3-C12 cycloalkyl groups; mono-, bi- or tricyclic C6-C14 aryl groups; heteroaryl groups chosen from pyridyl, thienyl, quinolyl, benzodioxanyl, benzodioxolyl and isoxazolyl groups; phenyl (C1-C4) alkyl and naphthyl (C1-C4) alkyl group; or R7 is the groups of formula: in which n=1, 2 or 3; the aryl or heteroaryl groups of R7 optionally being substituted with one or more groups chosen independently from halogens, C1-C4 alkyl, trifluoromethyl, C1-C4 alkylthio, C1-C4 alkyloxy, C1-C4 alkylsulphonyl, nitro, di ((C1-C4)alkyl) amino, phenyl, naphthyl and heteroaryl groups chosen from thienyl, furyl and pyridyl groups, and from groups â€”COOR, â€”CH2â€”COOR or â€”Oâ€”CH2COOR, R being a C1-C4 alkyl group, R4 and R5 are chosen, independently of each other, from hydrogen, a C1-C5 alkyl group or form, together with the nitrogen atom, a group chosen from piperidyl and morpholinyl groups, and the oxo group is in position 2 or 3 on the piperazine; and the addition salts thereof with pharmaceutically acceptable acids.