Patent ID: 6525042
Filing Date: 2003-02-25
Classification: A61P,C07C,C07D

Abstract:
A sulfonyl compound represented by the following formula (I): whereinR1 represents a hydrogen atom, a hydroxyl group, a nitro group, a cyano group, a halogen atom, an alkyl group, a hydroxyalkyl group, an alkoxyl group, an alkoxyalkyl group, a carboxyl group, a carboxyalkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, an alkoxycarbonylalkyl group, an alkylcarbonyloxy group or a group A1-B1â€” (in which A1 represents an amino group which may have one or two substituents, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B1 represents a single bond, a carbonyl group, an alkylene group, a carbonylalkyl group, a carbonylalkyloxy group or an alkylenecarbonyloxy group), R2 and R3 each independently represents a hydrogen atom, a halogen atom, an alkyl group, a hydroxyalkyl group or an alkoxyalkyl group or R2 or R3 may be coupled together with R1 to form a C1-3 alkylene or alkenylene group, R4 and R5 each independently represents a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group or an alkoxyl group (with the proviso that R4 and R5 do not represent a hydrogen atom at the same time), Q1 represents a saturated or unsaturated bicyclic or tricyclic fused ring group which may have a substituent, Q2 represents a single bond, an oxygen atom, a sulfur atom, a linear or branched C1-6 alkylene group, a linear or branched C2-6 alkenylene group, a linear or branched C2-6 alkynylene group, a group â€”N(R6)â€”COâ€” (in which R6 represents a hydrogen atom or an alkyl group), a group â€”N(R7)â€”(CH2)m-(in which R7 represents a hydrogen atom or an alkyl group and m stands for an integer of 0 to 6), Q3 represents any one of the following groups: â€ƒ(in which when the carbon atom to which each of R8, R9, R10, R11, R12, R13, R15 and R16 is bonded is not adjacent to a nitrogen atom, R8, R9, R10, R11, R12, R13, R15, and R16 each independently represents: a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxyl group, an alkoxyalkyl group, an alkoxyalkyloxy group, a hydroxyalkyl group, a hydroxyalkyloxy group, a hydroxyalkylsulfonyl group, a formyl group, a formylalkyl group, a formylalkylcarbonyl group, a formylalkylsulfonyl group, an alkylcarbonyl group, an alkylsulfonyl group, an alkylcarbonylalkyl group, an alkylsulfonylalkyl group, a carboxyl group, a carboxyalkyl group, a carboxyalkyloxy group, a carboxyalkylcarbonyl group, a carboxyalkylsulfonyl group, a carboxyalkylcarbonylalkyl group, a carboxyalkylsulfonylalkyl group, an alkoxycarbonyl group, an alkoxycarbonylalkyl group, an alkoxycarbonylalkyloxy group, an alkoxycarbonylalkylcarbonyl group, an alkoxycarbonylalkylsulfonyl group, an amino group which may have one or two substituents, an aminoalkyl group in which the amino moiety may have one or two substituents, an aminoalkyloxy group in which the amino moiety may have one or two substituents, an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents, an aminoalkylcarbonyloxy group in which the amino moiety may have one or two substituents, an aminocarbonyl group in which the amino moiety may have one or two substituents, an aminocarbonylalkyl group in which the amino moiety may have one or two substituents, an aminocarbonylalkyloxy group in which the amino moiety may have one or two substituents or a group A2-B2â€” (in which A2 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B2 represents a single bond, a carbonyl group or an alkylene group), when the carbon atom to which each of R8, R9, R10, R11, R12, R13, R15 and R16 is bonded is adjacent to a nitrogen atom, R8, R9, R10, R11, R12, R13, R15 and R16 each independently represents: a hydrogen atom, an alkyl group, a hydroxyalkyl group, a hydroxyalkylcarbonyl group, a hydroxyalkylsulfonyl group, a formyl group, a formylalkyl group, a formylalkylcarbonyl group, a formylalkylsulfonyl group, an alkylcarbonyl group, an alkylsulfonyl group, an alkylcarbonylalkyl group, an alkylsulfonylalkyl group, a carboxyl group, a carboxyalkyl group, a carboxyalkylcarbonyl group, a carboxyalkylsulfonyl group, a carboxyalkylcarbonylalkyl group, a carboxyalkylsulfonylalkyl group, an alkoxyalkyl group, an alkoxycarbonyl group, an alkoxycarbonylalkyl group, an alkoxycarbonylalkylcarbonyl group, an alkoxycarbonylalkylsulfonyl group, an aminoalkyl group in which the amino moiety may have one or two substituents, an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents, have one or two substituents, an aminocarbonyl group in which the amino moiety may have one or two substituents, an aminocarbonylalkyl group in which the amino moiety may have one or two substituents or a group A3-B3â€” (in which A3 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B3 represents a single bond, a carbonyl group or an alkylene group), R8 and R9, R10 and R11, R12 and R13, and R15 and R16 may each be coupled together with a carbon atom which constitutes the ring and represent a saturated or unsaturated 5- to 7-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, R14 and R17 each independently represents: a hydrogen atom, an alkyl group, a hydroxyalkyl group, a hydroxyalkylcarbonyl group; a hydroxyalkylsulfonyl group, an alkoxyl group, an alkoxyalkyl group, an alkoxyalkylcarbonyl group, an alkoxyalkylsulfonyl group, a formyl group, a formylalkyl group, a formylalkylcarbonyl group, a formylalkylsulfonyl group, an alkylcarbonyl group, an alkylcarbonylalkyl group, an alkylsulfonyl group, an alkylsulfonylalkyl group, a carboxyalkyl group, a carboxyalkylcarbonyl group, a carboxyalkylsulfonyl group, a carboxyalkylcarbonylalkyl group, a carboxyalkylsulfonylalkyl group, an alkoxycarbonyl group, an alkoxycarbonylalkyl group, an alkoxycarbonylalkylcarbonyl group, an alkoxycarbonylalkylsulfonyl group, an amino group which may have one or two substituents, an aminoalkyl group in which the amino moiety may have one or two substituents, an aminoalkyloxy group in which the amino moiety may have one or two substituents, an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents, an aminoalkyloxycarbonyl group in which the amino moiety may have one or two substituents, an aminocarbonyl group in which the amino moiety may have one or two substituents, an aminocarbonylalkyl group in which the amino moiety may have one or two substituents, and an aminocarbonyloxyalkyl group in which the amino moiety may have one or two substituents, R14 and R12 or R13 may be coupled together with a carbon atom constituting a ring and with a nitrogen atom to which R14 is bonded to form a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, R17 and R15 or R16 may be coupled together with a carbon atom constituting a ring and with a nitrogen atom to which R17 is bonded to form a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, and a, b, d, e and g each independently stands for an integer of 0 or 1, c stands for an integer of 0 to 3, f, h and i each independently represents an integer of 1 to 3, with the proviso that the sum of a, b and c stands for an integer of 2 or 3, the sum of d and e stands for an integer of 0 or 1 and the sum of f, g and h stands for an integer of 3 to 5), T1 represents a carbonyl group, or a group â€”CH(R18)â€” (in which R18 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, an alkoxyalkyl group, a carboxyalkyl group, an alkoxycarbonylalkyl group, an aryl group, an aralkyl group, a heteroaryl group, a heteroarylalkyl group or an aminoalkyl group in which the amino moiety may have a substituent), X1 and X2 each independently represents a methine group; salt thereof; or solvate thereof.