Patent ID: 7507405
Filing Date: 2009-03-24
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting angiogenesis in mammal comprising administering to the mammal an effective amount of a conjugate consisting essentially of one or more antibody fragments covalently modified by one or two nonproteinaceous polymer molecules at a free sulfhydryl group of a cysteine residue within the hinge region of the antibody fragment, wherein a disulfide bridge within the hinge region is avoided by substituting another amino acid for the corresponding cysteine residue within the hinge region in the opposite chain of said antibody fragment, wherein the apparent size of the conjugate is at least 500 kD, and wherein at least one antibody fragment comprises an antigen binding site that binds to a human vascular endothelial growth factor (VEGF) polypeptide.