Patent ID: 8404682
Filing Date: 2013-03-26
Classification: A61K,A61P,C07D

Abstract:
1. A method for the treatment of a mammalian subject, wherein the subject suffers from a hypoglutamatergic condition or a deficiency in the number or strength of excitatory synapses or in the number of AMPA receptors, such that memory or other cognitive functions are impaired, said method comprising administering to said subject, in a pharmaceutically acceptable carrier, an effective amount of a compound according to the chemical formula: wherein: W is oxygen; X, Y and Z are each independently —CR, wherein: R is H, —Br, —Cl, —F, —CN, —NO wherein: R F═O or S, A is a -C -C is a -C 3 -C 7 cycloalkyl which may be un-substituted or substituted, a -C 4 -C 7 azacycloalkyl, which may be un-substituted or substituted, a -C 7 -C 10 bicycloalkyl which may be un-substituted or substituted, a -C 7 -C 10 azabicycloalkyl which may be un-substituted or substituted, aryl which may be un-substituted or substituted or a heterocycle which may be un-substituted or substituted; B is —C═, C—R R R or a pharmaceutically acceptable salt thereof.