Patent ID: 6093744
Filing Date: 2000-07-25
Classification: C07C,C07D

Abstract:
A compound of formula ##STR4## or a pharmaceutically acceptable salt thereof wherein: R.sup.1 is hydrogen, alkyl, or alkoxy;R.sup.2 to R.sup.5 are alkyl, alkoxy, or unsubstituted or substituted phenyl;R.sup.6 is --CN,--(CH.sub.2).sub.0-1 --NR.sup.7 R.sup.8,--O--(CH.sub.2).sub.1-10 --Z wherein Z is --NR.sup.9 R.sup.10, OR.sup.1, or CO.sub.2 R.sup.1,--OC(.dbd.O)R.sup.11,--SR.sup.11,--SCN,--S(CH.sub.2).sub.1-10 Z,--S(O).sub.1-2 R.sup.12 wherein R.sup.12 is hydroxy, alkoxy, alkyl, (CH.sub.2).sub.1-10 Z or NR.sup.7 R.sup.8,--C(.dbd.O)XR.sup.11,--CH.sub.2 --R.sup.13 wherein R.sup.13 is (CH.sub.2).sub.0-5 --Y--(CH.sub.2).sub.0-5 Z, orwherein R.sup.7 and R.sup.8 are each independently selected from:--hydrogen, at least one of R.sup.7 and R.sup.8 is other than hydrogen,--(CH.sub.2).sub.1-10 Z wherein Z is as above and R.sup.9 and R.sup.10 are each independently selected from hydrogen, alkyl, and unsubstituted or substituted phenyl, orR.sup.9 and R.sup.10 are taken together with the nitrogen to which they are attached to form a ring selected from:--(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2,--(CH.sub.2).sub.2 --S--(CH.sub.2).sub.2,--(CH.sub.2).sub.2 --CR.sup.14 R.sup.15 --(CH.sub.2).sub.1-2, and--(CH.sub.2).sub.2 --NR.sup.16 --(CH.sub.2).sub.2, whereinR.sup.14, R.sup.15, and R.sup.16 are each independently selected from hydrogen, alkyl, and unsubstituted or substituted phenyl;--C(.dbd.Q)XR.sup.11 wherein X is a bond or NH wherein Q is O or S,R.sup.11 is hydrogen, alkyl, unsubstituted or substituted phenyl,--(CH.sub.2).sub.0-5 --Y--(CH.sub.2).sub.0-5 Z wherein Z is as defined above and Y is phenyl or a bond;--C(.dbd.O)CR.sup.17 R.sup.18 Z;--C(.dbd.O)NRCR.sup.17 R.sup.18 Z wherein R.sup.17 and R.sup.18 are each independently hydogen, alkyl, phenyl, substituted phenyl, or the side chain of a naturally occurring amino acid;--S(O).sub.1-2 R.sup.19 wherein R.sup.19 is alkyl, unsubstituted or substituted phenyl, naphthyl, or a heteroaromatic ring, or NR.sup.9 R.sup.10 orR.sup.7 and R.sup.8 are taken together with the nitrogen to which they are attached to form a ring:--(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --,--(CH.sub.2).sub.2 --S--(CH.sub.2).sub.2 --,--(CH.sub.2).sub.2 --CR.sup.14 R.sup.15 --(CH.sub.2).sub.1-2 --,--(CH.sub.2).sub.2 --NR.sup.16 --(CH.sub.2).sub.2 -- wherein R.sup.14, R.sup.15, and R.sup.16 are as above.