Patent ID: 7482320
Filing Date: 2009-01-27
Classification: A61K,A61P,G01N

Abstract:
1. A method of stimulating smooth muscle cell proliferation in tissues or organs and tissue repair in a subject comprising administering to said subject an amount of a CUB domain of VEGF-X polypeptide consisting essentially of the sequence from position 40 to 150 of the amino acid sequence depicted in SEQ ID NO: 7 or a polypeptide encompassing conservative amino acid changes thereof, in sufficient concentration to stimulate smooth muscle cell proliferation, wherein conservative amino acid changes include replacement of one or more amino acids of SEQ ID NO: 7 which do not affect the function of SEQ ID NO:7; and wherein the conservative amino acid changes result in a polypeptide having at least 95% amino acid homology to the amino acid sequence depicted in SEQ ID NO:7.