Patent ID: 6395719
Filing Date: 2002-05-28
Classification: A61K,A61P

Abstract:
A method for up-regulating choline acetyltransferase (ChAT) in mammals comprising administering to a mammal in need thereof, an effective amount of a compound of formula I: or a pharmaceutical acid addition salt or solvate thereof; where:R1 and R3 are independently hydrogen, methyl, benzoyl, substituted benzoyl, or C(O)â€”(C1-C6 alkyl); R2 is selected from the group pyrolidin-1-yl, piperidin-1-yl, and hexamethyleneimin-l-yl; where R2 is optionally the N-oxide; and optionally an acetyl choline esterase (AChE) inhibitor.