Patent ID: 8420641
Filing Date: 2013-04-16
Classification: A61P,C07D

Abstract:
1. A method of inhibiting CETP, comprising: administering to a subject a therapeutically effective amount of a compound of formula (I): wherein, R1 is alkyl-O—C(O)—, alkanoyl or heteroaryl, wherein said heteroaryl is optionally substituted with one to three substituents selected from halogen, dialkylamino, alkoxy, heterocyclyl, wherein said heterocyclyl is further optionally substituted with one to three substituents selected from alkyl, hydroxy or alkanoyl; R2 is alkyl; R3 is HOC(O)—R9-C(O)— or HOC(O)—R9-O—C(O)—, R9 is (C1-C4) alkyl, (C3-C6) cycloalkyl, (C1-C4) alkyl-(C3-C6)cycloalkyl or (C3-C6) cycloalkyl-(C1-C4)alkyl; R4 is alkyl or aryl-alkyl- optionally substituted by one to three alkyl or halogen; R5 is Hydrogen; R6 and R7 are independently alkyl, halogen, alkoxy, wherein said alkyl is optionally substituted with one to three halogen; or a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers.