Patent ID: 6409764
Filing Date: 2002-06-25
Classification: A61C,A61F,A61L,Y10S

Abstract:
A method of generating living bone having desired configuration in a mammal, said method comprising:providing a tissue penetrable device comprising portions having a plurality of holes therethrough, wherein said holes permit cells and vascular structures to grow through said tissue penetrable device, said tissue penetrable device having mechanical properties that allow the device to be configured into a desired form and retained substantially in said desired form; establishing a space with said tissue penetrable device in a mammal in such a way that a boundary is at least partially formed by said tissue penetrable device between said space and anatomical structures of said mammal surrounding said space, wherein said space has essentially the same conjuration as bone to be generated therein; placing at least one TGF-Beta protein in said space; allowing cells and blood vessels from said mammal to traverse said tissue penetrable device through said holes into said space; and generating bone in said space.