Patent ID: 6630598
Filing Date: 2003-10-07
Classification: C07C

Abstract:
A method for producing an N-acylnitroaniline derivative of the formula (1): wherein X may be the same or different and denotesa hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group, an alkoxy group, a phenylalkyl group, a phenylalkoxyl group, a phenyl group, a benzoyl group, an alkoycarbonyl group, an N-alkylaclyamino group, an aralkylacylamino group, an alkylthio group, an aralkylthio group, an arylthio group, a formyl group, an N,N-dialkylamino group, an alkenyl group, an alkynyl group, or a piperidyl group, n denotes an integer from 0 to 4, R1 denotes an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group or an aralkyloxy group, which comprises reacting a nitroaniline compound of formula (2): wherein X and n are the same as described above with an acid anhydride of formula (3a) or an acid halide of formula (3b): wherein R1 is the same as defined above and Z denotes a halogen atom, in the presence of a hydride of an alkali or an alkaline earth metal, the hydride of an alkali or an alkaline earth metal being present in an amount of about 1.8 moles or more per mol of nitroaniline compound, wherein the nitro group in the formulas (1) and (2) is located at an opposition in relation to the amino group.