Patent ID: 9078980
Filing Date: 2015-07-14
Classification: A61M

Abstract:
1. A method for localized therapeutic hypothermia of a myocardium, said method comprising: (a) providing a catheter assembly having: (b) providing a blood conditioning apparatus associated with said catheter assembly for controlled perfusion and/or drainage of conditioned or unconditioned blood to and from the myocardium, said blood conditioning apparatus including: (c) positioning a distal portion of said catheter assembly within a venous drainage structure of the myocardium, with said occlusion device disposed proximally of said perfusion port and said drainage port; (d) actuating said occlusion device to occlude substantially all venous drainage from the myocardium; (e) receiving drainage flow to said therapy isolation module through said venous drainage line; (f) controllably delivering at least a portion of said drainage flow to said therapy delivery module; (g) generating perfusate by conditioning venous flow, including said drainage flow, at said therapy delivery module with said perfusate temperature adjusting device, wherein said conditioning by said perfusate temperature adjusting device includes cooling the perfusate to less than about 35° C.; (h) controllably dispensing the perfusate in a retrograde direction to the venous drainage structure through said perfusion port; (i) controllably delivering a portion of said drainage flow to said therapy deactivation module; (j) generating systemic flow by conditioning said drainage flow at said therapy deactivation module; and (k) controllably dispensing the systemic flow to venous systemic circulation through said systemic port that is positioned in a venous flow structure.