Patent ID: 6093846
Filing Date: 2000-07-25
Classification: C07C

Abstract:
A process for preparing optically active 2-hydroxymethyl-3-phenylpropionic acid, comprising:reacting (RS)-2-hydroxymethyl-3-phenylpropionic acid with an optically active amine selected from the group consisting of optically active cis-1-amino-2-indanol, optically active .alpha.-methylbenzylamine and optically active 3-methyl-2-phenyl-1-butylamine in a solvent, to produce two diastereomeric salts, wherein one diastereomeric salt is less soluble than the other diastereomeric salt;separating the less soluble diastereomeric salt by fractional crystallization; anddecomposing the separated diastereomeric salt with an alkali or an acid.