Patent ID: 6613357
Filing Date: 2003-09-02
Classification: A61K,A61P

Abstract:
An osmotic device comprising:(a) a core comprising a therapeutically effective amount of pseudoephedrine which is delivered at a controlled rate over a period of about 18-24 hours; (b) a semipermeable membrane surrounding the core and a passageway through the semipermeable membrane; (c) an inert water soluble or erodible coating surrounding the semipermeable membrane and plugging the passageway; and (d) a fexofenadine-containing water soluble or erodible coating surrounding the inert water soluble coating for delivering all of the fexofenadine at a rapid rate over a period of less than about 90 min, wherein: 1) 10-25% of the PS is released within 3 hours; 2) 25-50% of the PS is released within 7 hours; 3) 50-66% of the PS is released within 11 hours; 4) 66-79% of the PS is released within 15 hours; and 5) 79-100% of the PS is released within 23 hours after exposure to an aqueous environment.