Patent ID: 8257746
Filing Date: 2012-09-04
Classification: A61K,A61P

Abstract:
1. A process for the conversion of at least one pharmaceutical ingredient into a tannate salt complex for incorporation into a therapeutic liquid or semi-solid dosage form, the process comprising: (a) dissolving the salt or free base of the active pharmaceutical ingredient in a pharmaceutically acceptable liquid in the presence of a dispersing agent and tannic acid under stirring, to form a dispersion wherein the tannic acid component is of either a natural or synthetic source; (b) combining the tannate salt complex of the active pharmaceutical ingredient without isolation or purification with pharmaceutically acceptable excipients to generate a therapeutic dosage form; wherein the active pharmaceutical ingredient is selected form the group consisting of an antinausea agent, an antiemetic, a sedative and an anticonvulsive and wherein the antinausea agent is selected from the group consisting of doxylamine, prochloroperazine, promethazine HCL, metochloropromide HCL and ondansetron HCL.