Patent ID: 9005633
Filing Date: 2015-04-14
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method for inactivating a live virus for use as an immunogenic composition comprising: a) exposing said virus to an inactivating psoralen, wherein said psoralen is selected from the group consisting of 4′-Aminomethyltrioxalen hydrochloride (AMT), 8-Methoxypsoralen (8-MOP), 4, 5′, 8-Trimethylpsoralen (TMP) and a combination thereof, and b) exposing said virus to a preselected intensity of an ultraviolet radiation for 5 to 30 minutes, which is sufficiently long to render the virus non-infectious but would not result in degradation of its antigenicity.