Patent ID: 8754243
Filing Date: 2014-06-17
Classification: C07D

Abstract:
1. A process for the preparation of cis-adamantane-2-spiro-3′-8′-[[[(2′-amino-2′-methylpropyl)amino]carbonyl]methyl]-1′,2′,4′-trioxaspiro[4.5]decane, of Formula III having no dimer impurity of Formula IV, wherein the process comprises, (a) reacting a compound of Formula II  in dichloromethane with an activating agent forming a mixed anhydride, and (b) reacting the mixed anhydride in situ with an ethanolic solution of 1,2-diamino-2-methylpropane to give a compound of Formula III, wherein 1.8-3 mole equivalents of 1,2-diamino-2-methylpropane are used in 20-80 times w/v of solvent system of dichloromethane and ethanol (in the ratio of 1:1 v/v).