Patent ID: 7456011
Filing Date: 2008-11-25
Classification: A61K,C07K

Abstract:
1. A Lactobacillus bacterium expressing a modified cyanovirin-N (CV-N) polypeptide comprising a core amino acid sequence at least 90% identical to SEQ ID NO:1 and an additional amino acid sequence immediately to the N-terminus of the core amino acid sequence, wherein the additional amino acid sequence consists of two to twenty amino acids, among which at least one of the first two amino acids is identical to its corresponding amino acid in the first two amino acids of a mature Lactobacillus CbsA protein following the cleavage of the CbsA protein signal sequence, wherein the modified CV-N polypeptide is derived from a precursor polypeptide, which consists of, from the N-terminus, the CbsA protein signal sequence, the additional amino acid sequence, and the core amino acid sequence, following the cleavage of the CbsA protein signal sequence, and wherein the modified CV-N polypeptide specifically binds to gp 120 of human immunodeficiency virus (HIV) and inhibits the infectivity of HIV.