Patent ID: 6699884
Filing Date: 2004-03-02
Classification: C07D

Abstract:
A compound, or a pharmaceutically-acceptable salt, tautomer or prodrug thereof, selected from the group consisting of:2,5-difluoro-4-[5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-chlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-chlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-fluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-fluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-cyanophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-cyanophenyl)-5â€”oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,4-dichlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,4-dibromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,4-difluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,5-dichlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,5-dibromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,5-difluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,4-dimethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,5-dimethylphenyl)-5-oxo-2,5-dihydro-3 furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methyl-4-chlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methyl-3-chlorophenyl)-5-oxo-2,5 dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methyl-4-fluorophenyl)-5-oxo-2,5 dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methyl-3-fluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methyl-4-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methyl-3-bromophenyl)-s-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methyl-4-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methyl-3-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-methyl-4-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methyl-3-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-cyano-4-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-cyano-3-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-chloro-4-methoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-chloro-3-methoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(2-methylpyridin-6-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(2-methylthiazol-4-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-methylthiazol-2-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3-pyridinyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(5-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-cyclohexyl-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-cyclopentyl-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H) -furanone; 3-(3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,5-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3,5-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3,5-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methyl-3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-cyano-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-cyano-3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-chloro-4-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylthiazol-4-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-pyridinyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(5-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 2,6-difluoro-4-[4,5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-chlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-chlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-fluorophenyl)-5-oxo2,5-dihydro-3 furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-fluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-cyanophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(4-cyanophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,4-dichlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,4-dibromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,4-difluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,5-difluoro-4-[4-(3,5-dichlorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,5-dibromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,5-difluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,4-dimethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3,5-dimethylphenyl)-5-oxo-2,6-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methyl-4-chlorophenyl)-s-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methyl-3-chlorophenyl)-5-oxo-25 dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methyl-4-fluorophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methyl-3-fluorophenyl)5-oxo-2,5 dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methyl-4-bromophenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methyl-3-bromophenyl)-5-oxo-2,5 dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methyl-4-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methyl-3-trifluoromethylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-methyl-4-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methyl-3-trifluoromethoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-cyano-4-methylphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-cyano-3-methylphenyl)-5-oxo-2,5 dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-chloro-4-methoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-chloro-3-methoxyphenyl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(2-methylpyridin-6-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(2-methylthiazol-4-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(4-methylthiazol-2-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(3-pyridinyl)-5-oxo-2-dihydro-3 furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(5-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-(2-methylpyridin-3-yl)-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-cyclohexyl-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 2,6-difluoro-4-[4-cyclopentyl-5-oxo-2,5-dihydro-3-furanyl]benzenesulfonamide; 3-phenyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H) -furanone; 3-(3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3,4-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,5-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3,5-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,5-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,4-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3,5-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-chlorophenyl)-4-[3,6-difluoro-4 (methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-methyl-4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-cyano-4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-cyano-3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-chloro-4-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(4-chloro-3-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-6-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylthiazol-4-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(4-methylthiazol-2-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(3-pyridinyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-(5-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl) phenyl]-2 (5H)-furanone; 3-cyclohexyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone; 3-cyclopentyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-2 (5H)-furanone.