Patent ID: 6544986
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof;wherein X is C&boxH;O;R3, R4 and R6 are each independently selected form the group consisting of hydrogen, (C1-C12)alkyl, substituted (C1-C12)alkyl, (C3-C8)cycloalkyl, substituted (C3-C8)cycloalkyl, (C2-C12)alkenyl, substituted (C2-C12)alkenyl, (C2-C2)alkynyl, substituted (C2-C12)alkynyl, (C6-C14)aryl, substituted (C6-C14)aryl, (C1-C12)alkyl (C6-C14)aryl, substituted (C1-C12)alkyl (C6-C14)aryl, (C6-C14)aryl (C1-C12)alkyl, substituted (C6-C14)aryl (C1-C12)alkyl, (C6-C14)aryl (C2-C12)alkenyl, substituted (C6-C14)aryl (C2-C12)alkenyl, (C6-C14)aryl (C2-C12)alkynyl, substituted (C6-C14)aryl (C2-C12)alkynyl, trifluoromethyl, halogen, cyano and nitro; â€”S(O)Râ€², â€”S(O)2Râ€², â€”S(O)2ORâ€² and â€”S(O)2NHRâ€², wherein each Râ€² is independently (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkyl or (C6-C14)aryl; â€”C(O)Râ€³, wherein Râ€³ is selected from the group consisting of hydrogen, (C1-C12)alkyl, substituted (C1-C12)alkyl, (C3-C8)cycloalkyl, substituted (C3-C8)cycloalkyl, (C1-C12)alkoxy, (C1-C12)alkylamino, (C2-C12)alkenyl, substituted (C2-C12)alkenyl, (C2-C12)alkynyl, substituted (C2-C12)alkynyl, (C6-C14)aryl, substituted (C6-C14)aryl, (C6-C14)aryloxy, (C6-C14)arylamino, (C1-C12)alkyl (C6-C14)aryl, substituted (C1-C12)alkyl (C6-C14)aryl, (C6-C14)aryl (C1-C12)alkyl, substituted (C6-C14)aryl (C1-C12)alkyl, (C6-C14)aryl (C2-C12)alkenyl, substituted (C6-C14)aryl (C2-C12)alkenyl, (C6-C14)aryl (C2-C12)alkynyl, substituted (C6-C14)aryl (C2-C12)alkynyl, and trifluoromethyl; â€”ORâ€²â€³ and â€”NRâ€²â€³2, wherein each Râ€²â€³ is independently selected from hydrogen, (C1-C12)alkyl, substituted (C1-C12)alkyl, (C3-C8)cycloalkyl, substituted (C3-C8)cycloalkyl, (C2-C12)alkenyl, substituted (C2-C12)alkenyl, (C2-C12)alkynyl, substituted (C2-C12)alkynyl, (C6-C14)aryl, substituted (C6-C14)aryl, (C1-C12)alkyl (C6-C14)aryl, substituted (C1-C12)alkyl (C6-C14)aryl, (C6-C14)aryl (C1-C12)alkyl, substituted (C6-C14)aryl (C1-C12)alkyl, (C6-C14)aryl (C2-C12)alkenyl, substituted (C6-C14)aryl (C2-C12)alkenyl, (C6-C14)aryl (C2-C12)alkynyl, substituted (C6-C14)aryl (C2-C12)alkynyl, (C6-C14)aroyl, substituted (C6-C14)aroyl, (C1-C12)acyl and trifluoromethyl; and â€”SRâ€³â€³, wherein Râ€³â€³ is selected from the group consisting of hydrogen, (C1-C12)alkyl, substituted (C1-C12)alkyl, (C2-C12)alkenyl, substituted (C2-C12)alkenyl, (C2-C12)alkynyl, substituted (C2-C12)alkynyl, (C6-C14)aryl, substituted (C6-C14)aryl, (C1-C12)alkyl (C6-C14)aryl, substituted (C1-C12)alkyl (C6-C14)aryl, (C6-C14)aryl (C1-C12)alkyl, substituted (C6-C14)aryl (C1 -C12)alkyl, (C6-C14)aryl (C6-C12)alkenyl, substituted (C6-C14)aryl (C2-C12)alkenyl, (C6-C14)aryl (C2-C12)alkynyl, substituted (C6-C14)aryl (C2-C12)alkynyl, and trifluoromethyl; and â€”NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic; wherein the substituted groups listed above are substituted with one or more substituents selected from the group consisting of hydroxy, methyl, (C1-C4)alkoxy, (C6-C14)aryl, (C2-C14)heterocyclic, halogen, trifluoromethyl, cyano, nitro, amino, carboxyl, carbamate, sulfonyl and sulfonamide; and the heterocyclic group contains at least one atom selected from oxygen, nitrogen and sulfur; with the proviso that â€”NR7R8 is other than imidazolyl when: (i) R3 is CN and R4 is H and R6 is methyl; (ii) R3, R4 and R6 are all H; or (iii) R3 and R4 are both H and R6 is methyl.