Patent ID: 6465009
Filing Date: 2002-10-15
Classification: A61K,A61P

Abstract:
A process for producing a pharmaceutical tablet, comprising the following steps:(a) granulating a formulation comprising a water soluble polyvinylpyrrolidone and at least one active ingredient together, wherein no organic solvents are included in the formulation, and wherein a saccharide of low moldability is included in the formulation; (b) compressing the product of the granulation into a tablet form; (c) humidifying the tablet by exposing the product of step (b) to an aerated environment at least about 50% to 100% relative humidity; and (d) drying the tablet, wherein the hardness of the tablet is between about 0.5 kilopounds to about 12.0 kilopounds, and further wherein the tablet has an in vivo disintegration time of about 1 second to about 40 seconds, and further wherein the tablet comprises an effective amount of the polyvinylpyrrolidone to achieve said in vivo disintegration time and said hardness factor.