Patent ID: 8975044
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated polynucleotide encoding an antibody that specifically binds one or more human frizzled receptors selected from the group consisting of FZD1, FZD2, FZD5, FZD7, and FZD8, wherein the antibody comprises: (a) a heavy chain CDR1 comprising GFTFSHYTLS (SEQ ID NO:1); a heavy chain CDR2 comprising VISGDGSYTYYADSVKG (SEQ ID NO:2); and a heavy chain CDR3 comprising NFIKYVFAN (SEQ ID NO:3); and (b) a light chain CDR1 comprising SGDNIGSFYVH (SEQ ID NO:7); a light chain CDR2 comprising DKSNRPSG (SEQ ID NO:8); and a light chain CDR3 comprising QSYANTLSL (SEQ ID NO:9); or a light chain CDR1 comprising SGDKLGKKYAS (SEQ ID NO:4); a light chain CDR2 comprising EKDNRPSG (SEQ ID NO:5); and a light chain CDR3 comprising SSFAGNSLE (SEQ ID NO:6).