Patent ID: 9211250
Filing Date: 2015-12-15
Classification: A61K,A61P,C08L,C12N

Abstract:
1. A composition comprising a heterogeneous polymeric micelle and a polynucleotide associated with the micelle, the micelle comprising: a first polymer, the first polymer being a block copolymer comprising a hydrophilic block and a hydrophobic block; and a second polymer compositionally distinct from the first polymer, the second polymer being a block copolymer comprising a hydrophilic block and a hydrophobic block, the hydrophobic block of the second polymer being associated with the hydrophobic block of the first polymer such that the micelle is stable in an aqueous medium at pH 7.4, wherein at least one of the first polymer or the second polymer comprises a pH-dependent, membrane-destabilizing polymer; wherein the hydrophilic block of the first polymer comprises a plurality of cationic monomeric residues in ionic association with the polynucleotide, wherein the hydrophilic block of the second polymer is a neutral hydrophilic block comprising a plurality of neutral polar residues, and wherein the first polymer or the second polymer is a block copolymer of Formula IA: wherein