Patent ID: 7195784
Filing Date: 2007-03-27
Classification: A61K,A61P

Abstract:
1. A method for selectively inhibiting COX2 enzyme relative to COX1 enzyme in a patient in need thereof which comprises administering to the patient in need thereof an effective amount of at least one isolated and purified withanolide selected from the group consisting of physagulin D (1→6)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside; 27-O-β-D-glucopyranosyl physagulin D; 27-O-β-D-glucopyranosyl viscosalactone B; 4,16-dihydroxy-5β,6β-epoxyphysagulin D; and, 4-(1-hydroxy-2,2-dimethylcyclo-propanone)-2, and 3-dihydrowithaferin A so as to produce the COX2 inhibition in the patient in need thereof.