Patent ID: 7901628
Filing Date: 2011-03-08
Classification: G01N,H01J,Y10T

Abstract:
1. A method for fractionating various components contained in a sample solution using a liquid chromatograph mass spectrometer after separating the sample into the components along a passage of time by a liquid chromatograph portion, and subsequently introducing the components to a mass spectrum aquisition portion and a fraction collector, comprising the steps of: setting a first mass spectrometry condition and first mass range information for determining the components to be separated; setting a second mass spectrometry condition and second mass range information for determining the components to be separated; carrying out a first mass scan on the separated components by the mass spectrum acquisition portion under the first spectrometry condition and obtaining first mass spectrum data; extracting first chromatogram data from the first mass spectrum data based on the first mass range information; carrying out a second mass scan on the separated components by the mass spectrum acquisition portion under the second mass spectrometry condition to obtain second mass spectrum data; extracting second chromatogram data from the second mass spectrum data based on the second mass range information; switching the first and second spectrometry conditions and cyclically repeating the first and second mass scans; adding the first and second chromatograph to obtain combined chromatogram data during a predetermined time period for analysis; and diverting the separated components in the fraction collector based on the combined chromatogram data to obtain fractionated components when said data indicates an objective component is present in the sample solution.