Patent ID: 6686505
Filing Date: 2004-02-03
Classification: C07B,C07C,C07D

Abstract:
A process for producing an optically active amino alcohol, comprising:a step in which a compound represented by general formula (A) â€ƒwherein R1 is an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have one or more substituents, a saturated or unsaturated aliphatic hydrocarbon or alicyclic hydrocarbon group, which may have one or more substituents, or a heteromonocyclic or heteropolycyclic group, which may have one or more substituents, R2 and R3 each independently denote a hydrogen atom, a halogen atom, a carboxyl group, a hydroxyl group, an alkoxy group, an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have one or more substituents, a saturated or unsaturated aliphatic hydrocarbon or alicyclic hydrocarbon group, which may have one or more substituents and which may contain a heteroatom, or a heteromonocyclic or heteropolycyclic group, which may have one or more substituents, any two of R1 to R3 may bond together so as to form a ring, and X denotes a nitro group or a cyano group, is reacted, in the presence or absence of a base, with an optically active nitrogen-containing compound, a compound of a metal belonging to group VIII of the periodic table, and a hydrogen donor so as to obtain a compound represented by general formula (B) â€ƒwherein R1, R2, R3, and X are as defined above, and * denotes an asymmetric carbon atom, from the compound represented by general formula (A); and a step in which a compound represented by general formula (C) â€ƒwherein R1, R2, and R3 are as defined above, k denotes an integer of 0 or 1, and * denotes an asymmetric carbon atom, is obtained from the compound represented by general formula (B).