Patent ID: 9212228
Filing Date: 2015-12-15
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody or antigen binding fragment thereof that binds to CLD18A2 but not to CLD18A1, and mediates killing of cells expressing CLD18A2, wherein the antibody comprises a combination of complementarity-determining regions (CDRs) selected from (i)-(v): (i) heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 45-52, positions 70-77, and positions 116-125 of SEQ ID NO: 115, respectively; and light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 49-53, positions 71-73, and positions 110-118 of SEQ ID NO: 122, respectively; (ii) heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 45-52, positions 70-77, and positions 116-126 of SEQ ID NO: 116, respectively; and light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 47-58, positions 76-78, and positions 115-123 of SEQ ID NO: 121, respectively; (iii) heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 45-52, positions 70-77, and positions 116-124 of SEQ ID NO: 117, respectively; and light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 47-52, positions 70-72, and positions 109-117 of SEQ ID NO: 123, respectively; (iv) heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 44-51, positions 69-76, and positions 115-125 of SEQ ID NO: 119, respectively; and light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 47-58, positions 76-78, and positions 115-122 of SEQ ID NO: 126, respectively; and (v) heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 45-52, positions 70-77, and positions 116-126 of SEQ ID NO: 118, respectively; and light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 47-58, positions 76-78, and positions 115-123 of SEQ ID NO: 125, respectively.