Patent ID: 6569835
Filing Date: 2003-05-27
Classification: A61P,C07H

Abstract:
A combination, comprising at least one compound of formula I wherein:R1 is phenyl or heteroaryl, wherein the aromatic or heteroaromatic ring is unsubstituted, or is mono- to trisubstituted by fluorine, chlorine, bromine, iodine, â€”OH, â€”CF3, â€”NO2, â€”CN, â€”(C1-C8)-alkoxy, â€”(C1-C8)-alkyl, â€”NH2, â€”NHâ€”R9, â€”N(R9)R10, â€”CHO, â€”COOH, â€”COOR11, â€”(C&boxH;O)â€”R12, â€”(C1-C6)-alkyl-OH, â€”(C1-C6)-alkyl(â€”OH)-phenyl, â€”(C1-C6)-alkyl-CF3, â€”(C1-C6)-alkyl-NO2, â€”(C1-C6)-alkyl-CN, â€”(C1-C6)-alkyl-NH2, â€”(C1-C6)-alkyl-NRâ€”R9, â€”(C1-C6)-alkyl-N(R9)R10, â€”(C1-C6)-alkyl-CHO, â€”(C1-C6)-alkyl-COOH, â€”(C1-C6)-alkyl-COOR11, â€”(C1-C6)-alkyl-(C&boxH;O)â€”R12, â€”Oâ€”(C1-C6)-alkyl-OH, â€”Oâ€”Oâ€”(C1-C6)-alkyl-CF3, â€”Oâ€”(C1-C6)-alkyl-NO2, â€”Oâ€”(C1-C6)-alkyl-CN, â€”(C1-C6)-alkyl-NH2, â€”Oâ€”(C1-C6)-alkyl-NHâ€”R9, â€”Oâ€”(C1-C6)-alkyl-N(R9)R10, â€”Oâ€”(C1-C6)-alkyl-CHO, â€”Oâ€”(C1-C6)-alkyl-COOH, â€”Oâ€”(C1-C6)-alkyl-COOR11, â€”Oâ€”(C1-C6)-alkyl-(C&boxH;O)â€”R12, â€”Nâ€”SO3H, â€”SO2â€”CH3, â€”Oâ€”(C1-C6)-alkyl-Oâ€”(C1-C6)-alkyl-phenyl, â€”(C1-C6)-alkylthio, or pyridyl, wherein one or more hydrogen(s) in the alkyl radicals is optionally replaced by fluorine, and wherein phenyl and pyridyl are unsubstiuted or monosubstituted by methyl, methoxy, or halogen; R2 is H, â€”OH, â€”CH2OH, â€”OMe, CHO, or â€”NH2; R3 is a sugar residue, disugar residue, trisugar residue, tetrasugar residue, wherein the sugar residue, disugar residue, trisugar residue or tetrasugar residue is unsubstituted or is mono- or polysubstituted by a sugar protective group, HOâ€”SO2, or (HO)2â€”PO; R4 is H, methyl, F, or â€”OMe; R9 to R12 each independently of one another is H or â€”(C1-C8)-alkyl; Z is â€”NHâ€”(C0-C16)-alkyl-C&boxH;Oâ€”, â€”Oâ€”(C0-C16)-alkyl-C&boxH;Oâ€”, â€”(C&boxH;O)mâ€”(C1-C16)-alkyl-(C&boxH;O)n, an amino acid residue, a diamino acid residue, wherein the amino acid residue or diamino acid residue is unsubstituted, or mono- or polysubstituted by an amino acid protective group, or a covalent bond; n is 0 or 1; m is 0 or 1; or a pharmaceutically tolerated salt, or a physiologically functional derivative thereof, and at least one statin.