Patent ID: 8816069
Filing Date: 2014-08-26
Classification: C07D

Abstract:
1. A process for producing an amide compound, comprising: reacting a ketone and hydroxylamine in the presence of an organic solvent to give an oxime (hereinafter, referred to as an oxime-forming step), conducting Beckmann rearrangement of the oxime using a Beckmann rearrangement catalyst to give an amide compound (hereinafter, referred to as a rearrangement step), and separating the amide compound thus produced and the solvent, and recycling the separated solvent into the oxime-forming step (hereinafter, referred to as a solvent-recycling step); wherein an amount of each of a halide, an aldehyde compound, an alcohol compound and a nitrile compound contained in the solvent separated in the solvent-recycling step and recycled into the oxime-forming step is controlled to an amount of 0.4 mol % or less based on the ketone as the starting material, wherein an amount of each of an aldoxime compound and an amidoxime compound contained in the reaction solution in the oxime-forming step is controlled to an amount of 0.4 mol % or less based on the oxime, and wherein the amide compound is laurolactam and/or caprolactam, the ketone is cyclododecanone and/or cyclohexanone, and the oxime is cyclododecanone oxime and/or cyclohexanone oxime.