Patent ID: 8637007
Filing Date: 2014-01-28
Classification: A61K,A61P,C12N,C12Y,Y02A

Abstract:
1. A chemically-modified activated factor VII (FVIIa) molecule comprising, (a) a FVIIa molecule selected from the group consisting of plasmatic FVIIa and recombinant FVIIa (rFVIIa); and (b) at least one chain of 1-4 sialic acid units, each chain covalently bound to a separate amino acid residue of said FVIIa molecule; wherein the in vivo half-life of said chemically-modified FVIIa molecule is prolonged in the blood of a mammal as compared to the in vivo half-life of a FVIIa molecule that is not chemically modified.