Patent ID: 7807384
Filing Date: 2010-10-05
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for identifying a candidate agent that inhibits the binding of low density lipoprotein binding protein-2 (LBP-2) to an LBP-2 binding molecule, the method comprising: contacting in vitro an LBP-2 polypeptide, an LBP-2 binding molecule and a candidate agent, wherein the LBP-2 polypeptide comprises an amino acid sequence that binds to LDL and (i) has at least 80% sequence identity to the amino acid sequence of SEQ ID NO: 7; (ii) is identical to a fragment of at least ten amino acid residues of SEQ ID NO:7; or (iii) differs by one or more conservative amino acid substitutions from the amino acid sequence of SEQ ID NO:7; and measuring the formation of a complex containing the LBP-2 polypeptide and the LBP-2 binding molecule, wherein a reduction in the formation of the complex in the presence of the candidate agent as compared with in the absence of the candidate agent indicates that the candidate agent inhibits the binding of LBP-2 to the LBP-2 binding molecule.