Patent ID: 7091334
Filing Date: 2006-08-15
Classification: C07H,Y10S

Abstract:
1. A process for the synthesis of a compound of Formula I, and pharmaceutically acceptable salts thereof, said process comprising: a) dissolving a first uridine nucleotide compound of one of the Formulas IIb–d in a polar, aprotic organic solvent and a hydrophobic amine; b) activating a phosphate group of said first uridine nucleotide compound with an activation agent of one of the Formulas IIIa–b and reacting with a second uridine nucleotide compound of Formulas IIb–d to yield a compound of Formula I; and c) purifying by chromatography said compound of Formula I, or a pharmaceutically acceptable salt thereof; wherein: X is selected from the group consisting of: Na + , NH 4 + and H, provided that all X groups are not H; wherein R 1 and R 2 are independently selected from the group consisting of: C 1 –C 8 alkyl, C 1 –C 8 cycloalkyl, and aryl, wherein said alkyl is optionally substituted with N,N-dimethylamino groups; wherein X is independently selected from the group consisting of: N-imidazolyl, N-tetrazolyl and halogen; wherein the polar, aprotic organic solvent comprises N,N-dimethylformamide or dioxane.