Patent ID: 8642278
Filing Date: 2014-02-04
Classification: C07C,C07D

Abstract:
1. A method of inhibiting proliferation of a cell, comprising contacting the cell with an effective amount of a compound represented by structural formula Ia: or a pharmaceutically acceptable salt thereof, wherein: Ring A is optionally substituted, and zero, one, or two of the ring atoms in Ring A are N; and Ring A is fused with zero, one, or two optionally substituted 3-15 membered monocyclic or polycyclic rings selected from the group consisting of aryl, heteroaryl, heterocyclyl, and cycloaliphatic; Y is an optionally substituted C X X each substitutable carbon is optionally substituted with a carbon substituent independently selected from the group consisting of —F, —Cl, —Br, —I, —CN,—NO each substitutable nitrogen is: optionally substituted with a nitrogen substituent independently selected from the group consisting of —CN, —NO optionally protonated or quaternary substituted to carry a positive charge which is balanced by a pharmaceutically acceptable counterion; wherein each R X provided the compound is not benzyl N,N′-bis(tert-butoxy carbonyloxy)carbamimidothioate or a salt represented by