Patent ID: 6399776
Filing Date: 2002-06-04
Classification: C07C,C07D

Abstract:
A process for preparing a compound of the formula wherein X and Y are the same and are selected from â€”CN, â€”CONH2, â€”CO(C1-C6)alkyl and â€”CONHOH, comprising: (1) reacting 3-hydroxy-4-methoxybenzaldehyde with a compound of the formula XCH2CO2H, wherein X is â€”CN, â€”CO2(C1-C6)alkyl, â€”CONH2 or â€”CONHOH, in the presence of a base, to form a compound of the formula wherein X and Y are the same and are selected from â€”CN, â€”CO2 (C1-C6)alkyl, â€”CONH2 and â€”CONHOH; and (2) reacting said compound of formula II with a triaryl or trialkylphosphine, an azo dicarboxylate, and either R-(+)-endo-norborneol or S-(âˆ’)-endo-norborneol, respectively.