Patent ID: 7960397
Filing Date: 2011-06-14
Classification: A61P,C07D

Abstract:
1. A method for improving the cosmetic appearance of mammalian epidermal cells, said method comprising applying a cosmetic composition to the mammalian epidermal cells, wherein the cosmetic composition comprises an effective amount of one or more 6,9-disubstituted purine derivatives of the general formula and their pharmaceutically acceptable salts, wherein the effective amount of the one or more 6,9-disubstituted purine derivatives or their pharmaceutically acceptable salts applied to the mammalian epidermal cells improves the cosmetic appearance of the mammalian epidermal cells; wherein R6 is an alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, heterocycloalkyl, heteroalkyl, or arylalkyl group containing at least one hydroxyl substitution thereon, and wherein R9 is a tetrahydropyran-2-yl, tetrahydrofuran-2-yl, 4-chlorobutyl, or 1-ethoxyethyl group; wherein alkyl denotes a branched or unbranched alkyl chain containing 1 to 8 carbon atoms, which is optionally substituted independently with 1 to 7 substituents selected from the group consisting of hydroxyl, halogen, alkyloxy, aryloxy, alkylamino, arylamino, amino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, alkyloxycarbonylamino, aryloxycarbonylamino, aryl, heterocycle, and heteroaryl; wherein alkenyl denotes a branched or unbranched alkenyl chain containing 2 to 7 carbon atoms with at least one double bond therein, which is optionally substituted independently with 1 to 6 substituents selected from the group containing halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, aryloxycarbonylamino and alkyloxycarbonylamino group, wherein alkynyl denotes a branched or unbranched alkynyl chain containing 2 to 7 carbon atoms with at least one triple bond therein, which is optionally substituted independently with 1 to 6 substituents selected from the group consisting of halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, alkyloxycarbonylamino, and aryloxycarbonylamino group; wherein cycloalkyl denotes a monocyclic or polycyclic alkyl group containing 3 to 15 carbon atoms, which is optionally substituted independently with 1 to 7 substituents selected from the group consisting of halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl aryloxycarbonylamino, and alkyloxycarbonylamino group; wherein aryl denotes a aromatic carbocyclic group containing 6 to 18 carbon atoms with at least one aromatic ring or a multiple condensed ring with at least one aromatic ring, which is substituted independently with 1 to 7 substituents selected from the group consisting of halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, aryloxycarbonylamino and alkyloxycarbonylamino group; wherein heterocycle denotes a heterocyclic group containing 4 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen atom, sulphur atom, and nitrogen atom, which is optionally substituted independently at with 1 to 7 substituents selected from the group consisting of alkyl, halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, aryloxycarbonylamino, and alkyloxycarbonylamino group; wherein heteroaryl denotes a heterocycle in which at least one heterocyclic ring is aromatic, which is optionally substituted independently with 1 to 7 substituents selected from the group consisting of alkyl, halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulpho, sulphamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, aryloxycarbonylamino, and alkyloxycarbonylamino group; wherein heterocycloalkyl denotes a —R wherein heteroarylalkyl denotes a —R wherein arylalkyl denotes a —R wherein halogen denotes a fluorine, bromine, chlorine, or iodine atom, wherein hydroxy denotes an —OH group, wherein mercapto denotes a —SH group, wherein amino denotes a —NH wherein carbamoyl denotes a —CONH wherein cyano denotes a —CN group, wherein carboxyl denotes a —COOH group, wherein nitro denotes a —NO wherein sulpho denotes a —SO wherein sulphamido denotes the SO wherein acyl denotes a —C(O)R wherein acyloxy denotes a —O—C(O)R wherein acylamino denotes a —NHCOR wherein alkyloxycarbonylamino denotes a —NHCOOR wherein aryloxycarbonylamino denotes a —NHCOOR wherein alkyloxy denotes a —OR wherein aryloxy denotes a —OR wherein alkylamino denotes a —NR wherein arylamino denotes a —NR wherein alkylthio denotes a —SR wherein arylthio denotes a —SR