Patent ID: 6103870
Filing Date: 2000-08-15
Classification: A61K,C07K

Abstract:
A peptide of formula IX-Leu-Asp-Z IwhereinX is a group amide-linked to the nitrogen atom of Leu, said group having a ring structure bonded to the carbonyl carbon of said amide-linkage by a spacer having a length of zero to about two methylene groups, said ring structure being a 5-membered ring, a 6-membered ring, a 6-membered ring fused to another 6-membered ring, or a 6-membered ring fused to a 5-membered ring, the length of X, including said spacer and carbonyl carbon, being about that of 3-quinolinecarbonyl or smaller, unless; (i) said ring structure of X is substituted with a C.sub.1 -C.sub.2 alkyl or hydroxyl group, (ii) the .alpha.-amino group of the X amino acid residue is acylated with a C.sub.1 -C.sub.6 acyl group or (iii) X together with the nitrogen atom of said Leu forms a phthalimido, a 1,2,3,4-tetrahydroquinazoline-2,4-dione-3-yl or 5-phenylhydantoin-3-yl group; andZ is Xaa-NCy.sup.1 where Xaa is Val, Ile, Leu or an amino acid residue having a side chain that contains one or two fused aromatic rings and NCy.sup.1 is a cyclic ring-containing group having a ring nitrogen atom that forms an amide bond with the .alpha.-carboxyl group of Xaa, and whose cyclic ring contains 5- or 6-atoms including said ring nitrogen atom.