Patent ID: 6124464
Filing Date: 2000-09-26
Classification: A61P,C07D

Abstract:
An improved process for the preparation of a magnesium salt of a substituted sulfinyl heterocyclic compound containing an imidazole moiety according to Formula I ##STR8## wherein Ar is ##STR9## Z is ##STR10## X is ##STR11## wherein N inside the benzene ring of the benzimidazole moiety means that one of the carbon atoms substituted by R.sub.7 -R.sub.10 optionally may be exchanged for a nitrogen atom without any substituents;R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, alkyl, alkylthio, alkoxy, fluorine-substituted alkoxy, alkoxyalkoxy, dialkylamino, piperidino, morpholino, halogen, phenylalkyl and phenylalkoxy, wherein alkyl and alkoxy groups may be branched or linear or contain a cyclic alkyl group;R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of hydrogen, alkyl and aralkyl;R.sub.6 is selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkyl and alkoxy;R.sub.7 -R.sub.10 are the same or different and are selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, oxazolyl, and trifluoroalkyl;R.sub.11 is hydrogen; andR.sub.12 and R.sub.13 are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl or alkoxy groups, wherein alkoxy groups may be branched or straight C.sub.1 -C.sub.9 chains or contain a cyclic alkyl group,wherein the improvement is mixing the substituted sulfinyl heterocycle of Formula I with a weak base selected from the group consisting of lower alkyl amines, di-lower alkyl amines, tri-lower alkyl amines and ammonia and a magnesium source selected from the group consisting of magnesium acetate, magnesium nitrate, magnesium sulfate, magnesium carbonate and magnesium chloride.