Patent ID: 8415479
Filing Date: 2013-04-09
Classification: A61P,C07C,C07D

Abstract:
1. A compound of Formula (I) or a salt thereof: wherein R R X is —C(R L is alkylene (some carbon atoms in the alkylene optionally form a cycloalkyl ring), alkenylene, alkynylene, cycloalkylene, alkyleneoxyalkylene, alkylenethioalkylene, alkylene-SO-alkylene, or alkylene-SO p represents an integer of 0 or 1; A is a group represented by any one of the following Formulae (a), (b) or (c): wherein R 10 and R 11 are the same or different, and each represents hydrogen or straight- or branched-chain alkyl; and m represents an integer of 0 to 10, wherein R Y represents CH or nitrogen; Z represents CH n represents an integer of 0 to 3; U represents alkylene; and t represents an integer of 0 or 1, wherein R V is alkylene, alkyleneoxyalkylene, oxyalkylene, alkyleneoxy, or oxygen; q represents an integer of 0 or 1; U and t are as defined above; and Ar represents aryl having one or two substituents (the one or two substituents optionally form a ring with a part of carbon atoms in the aryl group), 5- to 6-membered ring aryl group having one or two identical or different heteroatoms optionally having one or two substituents, or benzo-fused heteroaryl optionally having one to three substituents; and B represents COOR wherein R′ represents alkyl; or a heterocyclic group: a 1H-tetrazol-5-yl group; a 4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl group; a 4,5-dihydro-5-thioxo-4H-1,2,4-oxadiazol-3-yl group; or a 4,5-dihydro-5-oxo-1,2,4-thiadiazol-3-yl group, represented by the following formulae (sequentially from the left)