Patent ID: 6537768
Filing Date: 2003-03-25
Classification: A61K,A61P,C07K,G01N,Y02A

Abstract:
A method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease, comprising:(a) obtaining a sample from said subject; (b) contacting said sample with a histone H1-like antigen, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of said histone H1-like antigen, or said pANCA-reactive fragment thereof, and antibody to said histone H1-like antigen; and (c) detecting the presence or absence of said complex, wherein said histone H1-like antigen comprises a protein immunoreactive with NANUC-2 and having an amino acid sequence having at least 70% amino acid identity with SEQ ID NO: 27, and wherein the presence of said complex indicates that said subject has UC.