Patent ID: 9005907
Filing Date: 2015-04-14
Classification: G01N

Abstract:
1. An immunohistochemical method for typing a medulloblastoma as a WNT pathway tumor, a sonic hedgehog (SHH) pathway tumor, or a non-WNT/non-SHH tumor, said method comprising determining a protein expression profile for a sample obtained from said medulloblastoma by detecting expression of at least two biomarker proteins, wherein the biomarker proteins comprise (a) GAB1 and YAP1; (b) GAB1 and β-catenin; (c) GAB1 and filamin A; or (d) filamin A and β-catenin; and typing said medulloblastoma as a WNT pathway tumor, a SHH pathway tumor, or a non-WNT/non-SHH tumor based on said protein expression profile.