Patent ID: 9163285
Filing Date: 2015-10-20
Classification: A61K,A61P,C12N,C12Q,Y10T

Abstract:
1. A method of upregulating a function of and/or the expression of a Tristetraproline (TTP) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 90% sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 nucleotides within nucleotides 1 to 970 of SEQ ID NO: 3, 1 to 1117 of SEQ ID NO: 4 and 1 to 297 of SEQ ID NO: 5; thereby upregulating a function of and/or the expression of the Tristetraproline (TTP) polynucleotide in patient cells or tissues in vivo or in vitro.