Patent ID: 8322637
Filing Date: 2012-12-04
Classification: A61K,B02C

Abstract:
1. A method for micronization of a protein particle dispersion or a dispersion of particles comprising a protein, the protein having a predetermined level of biological activity, the method comprising: introducing the dispersion into a vortex chamber milling apparatus; and milling the dispersion under milling conditions comprising one or more parameters selected from the group consisting of an input pressure in the range of 1 to 7 Bars, an injector pressure in the range of 0.2 to 5 Bars, a loading rate in the range of 0.1 to 5 kg/hour, and a gas flow in the range of 30 to 100 m thereby obtaining a protein powder which retains at least 80% of the predetermined level of biological activity, and has a particle size distribution in the range of 5 to 100 μm or which exhibits a 30 to 400-fold reduction of the original size of the particles in the dispersion.