Patent ID: 6723744
Filing Date: 2004-04-20
Classification: A61P,C07D

Abstract:
A compound of the formula or the pharmaceutically acceptable salt thereof; whereinW is oxygen, CH2, CF2, NR12, S(O)m wherein m is 0, 1 or 2; R1, R2, and R3 are each independently selected from the group consisting of hydrogen, halo, cyano, trifluoromethyl, trifluomethoxy and (C1-C6)alkyl; R4 is hydrogen, halo, cyano, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C3-C10)cycloalkyl, (C3-C10)cycloalkyl(C1-C6)alkyl, â€”OR9, â€”S(O)2NR10R11, â€”C(O)NR10R11, â€”C(O)R10, â€”CH(OH)R10, â€”NR12C(O)R10, â€”NR12C(O)NR10R11, â€”NR12S(O)2R10 or â€”S(O)nR10 wherein n is 0, 1 or 2; R5 is hydroxy, or, (C1-C4)alkoxy; R6 is hydrogen, â€”C(O)CH3, (C1-C6)alkyl, or phenyl(C1-C6)alkyl; R7 is hydrogen or (C1-C6)alkyl; R8 is OR12 or NR9R12; R9 for each occurrence is independently hydrogen, (C1-C12)alkyl, (C3-C10)cycloalkyl; R10 for each occurrence is independently hydrogen, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C3-C10)cycloalkyl, (C3-C9)cycloalkyl(C1-C6)alkyl; R11 for each occurrence is independently hydrogen, (C1-C6)alkyl, (C3-C10) cycloalkyl or (C3-C9)cycloalkyl(C1-C6)alkyl; R12 for each occurrence is independently hydrogen or (C1-C6)alkyl; and R13 is hydrogen, halo or (C1-C6)alkyl.