Patent ID: 9199969
Filing Date: 2015-12-01
Classification: A01N,A61K,C07D

Abstract:
1. A method of making a dihydroquinazolinone compound of formula (I) wherein R is selected from the group consisting of: the method comprising: Buchwald-Hartwig coupling a halogenized nitrophenyl compound with a piperazine to form a nitrophenyl piperazine compound; reducing the nitrophenyl piperazine compound and cyclizing to form a tetrahydroquinazolin-6-yl-piperazine compound; mixing the tetrahydroquinazolin-6-yl-piperazine compound with an acid to form a 6-piperazinyl-3,4-dihydroquinazolin-2(1H) compound; and reductively aminating the 6-piperazinyl-3,4-dihydroquinazolin-2(1H) compound in the presence of one or more selected from the group consisting of an aldehyde, an organosulfur compound, and a reducing agent to form the dihydroquinazolinone compound of formula (I).