Patent ID: 6255120
Filing Date: 2001-07-03
Classification: C07B,C07C,C40B

Abstract:
A combinatorial chemical library for biological assay comprising a plurality of members of the Formula I:(T'-L).sub.q -[S]--C(O)--L'-Z Iwherein:T' is a tag;L is a first linker;T'-L- together form an identifier residue;q is 0-30;[S] is a solid support;-L' is a second linker;-Z is a compound of formula ##STR195##wherein:R.sup.1 is chosen from the group consisting of alkyl, aralkyl, aryl, --(CH.sub.2).sub.n --NHC(O)R.sup.5 and --(CH.sub.2).sub.n -cycloalkyl; where n=1-4;R.sup.2 is chosen from the group consisting of alkyl, aralkyl, aryl, aryloxyalkyl, cycloalkyl, --(CH.sub.2).sub.n -cycloalkyl, heteroaryl, --CH(.sup.6)OC(O)NHR.sup.5, ##STR196##wherein m=0-3; or R.sup.2 is the descarboxy residue of an N-capped-.alpha.-amino acid;Y is --NR.sup.3 R.sup.4 or --OR.sup.9 ;R.sup.3 is H;R.sup.4 is selected from the group consisting of heterocycloalkyl, --CH(.sup.5)C(O)NHR.sup.10, -benzylpyrrolidinyl-, N-benzylpiperidinyl- and --CH(R.sup.5)C(O)NHCH(R.sup.6)C(O)NHR.sup.7 ; orR.sup.3 and R.sup.4 together are ##STR197##R.sup.5 is selected from the group consisting of alkyl, aralkyl and aryl;R.sup.6 is H, lower alkyl, aryl or aralkyl;R.sup.7 is H or alkyl;R.sup.8 is chosen from the group consisting of H, R.sup.5, C(O)R.sup.5, C(O)OR.sup.5 and --SO.sub.2 R.sup.5 ;R.sup.9 is alkyl, aryl, aralkyl or R.sup.7 CH.dbd.CH(CH.sub.2).sub.n --; andR.sup.10 is lower alkyl, aryl or aralkyl.