Patent ID: 6262260
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A method for preparing a compound of formula (II) ##STR6##or a pharmaceutically acceptable salt thereof, whereinR.sup.1 is hydrogen or alkyl; andR.sup.2, R.sup.3, R.sup.4, and R.sup.5 are independently selected from the group consisting of hydrogen, halo, alkyl, and nitro;the method comprising:(a) decarboxylating a compound of formula (I) at about .degree.C. to about 180.degree. C. ##STR7##in a solvent of formula (III) ##STR8##wherein R.sup.6 and R.sup.7 are independently methyl or ethyl; and(b) reacting the product from step (a) with base.