Patent ID: 8846726
Filing Date: 2014-09-30
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a cancer selected from cancer of the colon, pancreatic cancer, breast cancer, prostate cancer, lung cancer, brain cancer, ovarian cancer, cervical cancer, testicular cancer, renal cancer, cancer of the head and neck, lymphoma, leukemia, and melanoma in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound of formula: or a pharmaceutically acceptable salt thereof, in combination with an antibody selected from an anti-CLTA-4 antibody and an anti-PD-1 antibody, wherein: W, X R R R R Cy R R R R R R R R or R or R or R a is 0 or 1; b is 0 or 1; m is 1; n is 0 or 1; p is 0 or 1; t is, independently, 1, 2, 3, 4, 5 or 6; u is, independently, 0, 1, 2, 3, 4, 5 or 6; and v is, independently, 0, 1, 2, 3, 4, 5 or 6.