Patent ID: 6525198
Filing Date: 2003-02-25
Classification: C07D

Abstract:
A method for the preparation of 4,6-dichloropyrimidine from 4-chloro-6-methoxypyrimidine comprising reacting 4-chloro-6-methoxypyrimidine with at least one sulphur-containing chlorinating agent selected from the group consisting of SCl2, SOCl2, and SO2Cl2 in the presence of at least one phosphorus compound having the formulaR3P&boxH;Ynâ€ƒâ€ƒ(1), in whichR represents C1-C10-alkyl or C6-C10-aryl, each of which may optionally be substituted by up to five identical or different substituents selected from the group consisting of fluorine, chlorine, bromine, C1-C4-alkyl, and C1-C4-alkoxy, Y represents oxygen or sulphur, and n represents zero or 1.