Patent ID: 9034819
Filing Date: 2015-05-19
Classification: A61K,A61P

Abstract:
1. A method for lowering total cholesterol levels, LDL-cholesterol levels, or triglyceride levels in a human in need thereof comprising: identifying a human in need of a reduction in total cholesterol levels, LDL-cholesterol levels, or triglyceride levels; and administering to the human a pharmaceutical formulation comprising at least one exendin or exendin analog agonist once per week in an amount sufficient to maintain a steady state geometric mean plasma concentration of the exendin or exendin analog agonist of 145 pg/mL to 700 pg/mL to reduce total cholesterol levels, LDL-cholesterol levels, or triglyceride levels in the patient wherein the amount is about 2.0 mg to about 5 mg, and wherein a dosage of the formulation comprises about 5% (w/w) of exenatide, about 2% (w/w) of sucrose, and about 93% (w/w) of a poly(lactide-co-glycolide) polymer.