Patent ID: 8409166
Filing Date: 2013-04-02
Classification: A61B,A61M

Abstract:
1. A method for delivery of a therapeutic or diagnostic agent, the method comprising: forming a substantially closed chamber within or adjacent to an organ, administering a test fluid into the closed chamber at a given flow rate and measuring a peak pressure at which delivery to a region deep to a superficial histological layer within the organ commences, administering a fluid comprising a therapeutic or diagnostic agent to the histological layer within an organ, by forming a substantially closed chamber within or adjacent the organ, and delivering the fluid at a preselected pressure, flow rate or volume of administration to direct delivery of the fluid to the histological layer of the organ, wherein controlling at least one of the pressure, the flow rate or the volume comprises administering the fluid (1) as part of a fluid flow into the closed chamber during which the peak pressure is not exceeded, when selective delivery only to a superficial histological layer is desired, or (2) as part of a fluid flow into the closed chamber during which the peak pressure is equaled or exceeded, when selective delivery to a region deep to the superficial histological layer is desired.