Patent ID: 9018238
Filing Date: 2015-04-28
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating a disease, with the pathological condition of which the activation of casein kinase 1δ or casein kinase 1ε is associated, comprising: administering to a subject at least one of an oxazolone derivative represented by the following general formula (1), a salt thereof, a solvate thereof, or a hydrate thereof: wherein in the formula (1), R wherein, in the formula (2), each of A wherein, in the formula (2), R wherein, in the formula (2), if there are a plurality of substituents, a ring may be formed by such a plurality of substituents; wherein in the formula (3a) or (3b), A wherein, in the formula (3a) or (3b), A wherein, in the formula (3a) or (3b), R wherein, in the formula (4), R wherein, in the formula (4), if there are a plurality of substituents, a ring may be formed by such a plurality of substituents; wherein in the formula (5), n represents an integer of 1 to 10 and a lower alkyl portion or lower alkenyl portion represented by Cn may be any one of a linear portion, a branched portion, a cyclic portion and a combination thereof, containing 1 to 10 carbon atoms; wherein, in the formula (5), R wherein, in the formula (5), if there are a plurality of substituents, a ring may be formed by such a plurality of substituents; wherein R wherein the disease is a circadian rhythm sleep disorder or depressive disorder, and wherein the subject is a subject in need of treatment of circadian rhythm sleep disorder or depressive disorder.