Patent ID: 6153626
Filing Date: 2000-11-28
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (I) ##STR36## wherein m is 1;n is 1;R.sup.1 is selected fromhydrogen;a branched or straight C.sub.1 -C.sub.6 alkyl;C.sub.3 -C.sub.8 cycloalkyl;C.sub.4 -C.sub.8 (alkyl-cycloalkyl) wherein alkyl is C.sub.1 -C.sub.2 alkyl and cycloalkyl is C.sub.3 -C.sub.6 cycloalkyl;benzyl; ##STR37## where G is a hydroaromatic or a heteroaromatic group having 5 or 6 atoms, and where the heteroatoms are selected from O, S and N; and ##STR38## and wherein n=0 or 1; C.sub.6 -C.sub.10 aryl; or heteroaryl having from 5 to 10 atoms selected from any of C, S, N and O; wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH.sub.3, (CH.sub.2).sub.p CF.sub.3, halogen, CONR.sup.5 R.sup.4, COOR.sup.5, COR.sup.5, (CH.sub.2).sub.p NR.sup.5 R.sup.4, (CH.sub.2).sub.p CH.sub.3 (CH.sub.2).sub.p SOR.sup.5 R.sup.4, (CH.sub.2).sub.p SO.sub.2 R.sup.5, and (CH.sub.2).sub.p SO.sub.2 NR.sup.5, wherein R.sup.4 and R.sup.5 is each and independently as defined for R.sup.1 above and p is 0, 1 or 2;(C.sub.1 -C.sub.2 alkyl)-(C.sub.6 -C.sub.10 aryl); or (C.sub.1 -C.sub.2 alkyl)heteroaryl, the heteroaryl moieties having from 5 to 10 atoms selected from any of C, S, N and O, and where the aryl or heteroaryl may optionally and independently be substituted by 1 or 2 substituents independently selected from any of hydrogen, CH.sub.3, CONR.sup.5 R.sup.4, COOR.sup.5, COR.sup.5, (CH.sub.2).sub.q NR.sup.5 R.sup.4, (CH.sub.2).sub.q CH.sub.3 (CH.sub.2).sub.q SOR.sup.5 R.sup.4, (CH.sub.2).sub.q SO.sub.2 R.sup.5, (CH.sub.2).sub.q SO.sub.2 NR.sup.5, and (CH.sub.2).sub.q OR.sup.4, wherein R.sup.4 and R.sup.5 is each and independently as defined for R.sup.1 above and q is 0, 1 or 2;A is ##STR39## wherein R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, and R.sup.18 is each and independently as defined for R.sup.1 above and wherein the phenyl ring of each A substituent may be optionally and independently substituted by 1 or 2 substituents Z.sup.1 and Z.sup.2 which are each and independently selected from hydrogen, CH.sub.3, (CH.sub.2).sub.r CF.sub.3, halogen, CONR.sup.2 R.sup.3, CO.sub.2 R.sup.2, COR.sup.2, (CH.sub.2).sub.r NR.sup.2 R.sup.3, (CH.sub.2).sub.r CH.sub.3 (CH.sub.2).sub.r SOR.sup.2, (CH.sub.2).sub.r SO.sub.2 R.sup.2 and (CH.sub.2).sub.r SO.sub.2 NR.sup.2 R.sup.3 wherein R.sup.2 and R.sup.3 is each and independently as defined for R.sup.1 above and wherein r is 0, 1, or 2; X is O, S or NR.sup.19 where R.sup.19 is as defined for R.sup.1,B is a substituted or unsubstituted aromatic, heteroaromatic, hydroaromatic or heterohydroaromatic moiety having from 5 to 10 atoms selected from any of C, S, N and O, optionally and independently substituted by 1 or 2 substituents independently selected from hydrogen, CH.sub.3, (CH.sub.2).sub.t CF.sub.3, halogen, (CH.sub.2).sub.t CONR.sup.5 R.sup.4, (CH.sub.2).sub.t NR.sup.5 R.sup.4, (CH.sub.2).sub.t COR.sup.5, (CH.sub.2).sub.t COOR.sup.5, OR.sup.5, (CH.sub.2).sub.t SOR.sup.5, (CH.sub.2).sub.t SO.sub.2 R.sup.5, and (CH.sub.2)tSO.sub.2 NR.sup.5 R.sup.4, wherein R.sup.4 and R.sup.5 is each and independently as defined for R.sup.1 ; and t is 0, 1, 2 or 3;as well as pharmaceutically acceptable salts of the compounds of the formula (I), and isomers, hydrates, isoforms and prodrugs thereof.