Patent ID: 7850966
Filing Date: 2010-12-14
Classification: A61J,A61P,C07K

Abstract:
1. A method for the treatment of breast cancer in a patient comprising administering to the patient an antibody or a fragment thereof that is capable of binding to the extracellular domain of HER2, which comprises an antibody light chain variable domain of SEQ ID NO: 1, and an antibody heavy chain variable domain of SEQ ID NO: 2, wherein the light chain variable domain of SEQ ID NO: 1 comprises an amino acid substitution selected from the group consisting of N30(VL)S; T31(VL)S; Y49(VL)D, and Y49(VL)W numbered according to the Kabat numbering system, and the heavy chain variable domain of SEQ ID NO: 2 comprises an amino acid substitution selected from the group consisting of D98(VH)W, F100(VH)P; Y 102(VH)K; and Y102(VH)L, numbered according to the Kabat numbering system.