Patent ID: 9119788
Filing Date: 2015-09-01
Classification: A61K,B01J,Y10T

Abstract:
1. A method for producing particles with length-width ratios of a largest particle dimension to a smallest particle dimension which is fixed at an angle of 90° in relation to the largest particle dimension in a range of from 1.0 to less than about 1.4 from a pharmaceutical substance, the method comprising the following stages: (a) providing a melt of the pharmaceutical substance; (b) producing droplets of the melt by spraying the melt into a processing chamber in which a spouted bed of fluidized solid particles is formed; (c) repeatedly guiding solid particles of the pharmaceutical substance past the sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and which has a temperature that is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; and (d) removing particles from the processing chamber as a function of the particle size; wherein the temperature of the process gas jet which is guided in a defined way is 10° C. to 40° C. below the solidification point of the melt.