Patent ID: 6150099
Filing Date: 2000-11-21
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
A method for identifying a compound which modulates the activity of an NF-AT polypeptide, comprising(i) contacting an isolated NF-AT polypeptide or portion thereof sufficient for interacting with a molecule, with the molecule and a compound under conditions in which, but for the presence of the compound, the NF-AT polypeptide or portion thereof and the molecule interact, wherein the NF-AT polypeptide is encoded by a nucleic acid which hybridizes to a nucleic acid having SEQ ID NO: 45 in 5.times. SSC at 42.degree. C.; and(ii) determining the level of interaction between the NF-AT polypeptide or portion thereof and the molecule in the presence relative to the absence of the compound, such that a difference in the level of interaction between the NF-AT polypeptide or portion thereof and the molecule in the presence relative to the absence of the compound indicates that the compound modulates the activity of an NF-AT polypeptide.