Patent ID: 8821850
Filing Date: 2014-09-02
Classification: A61K,C08G,C08L

Abstract:
1. A conjugate comprising an antibody and one or more D-carrying polymeric scaffolds connected to the antibody, each polymeric scaffold having Formula (Ic): wherein: each occurrence of D is independently a therapeutic agent having a molecular weight of ≦5 kDa; each D-carrying polymeric scaffold comprises poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) having a molecular weight ranging from about 2 kDa to about 40 kDa; L each occurrence of  in  is independently a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; and the  in between L each occurrence of  is independently a second linker not yet connected to the antibody, in which L between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1 , and each occurrence of the second linker is distinct from each occurrence of the first linker; each occurrence of  is independently a third linker that connects each D-carrying polymeric scaffold to the antibody in which the terminal  attached to L m is an integer from 1 to 300, m m m m the sum of m, m provided that the total number of L