Patent ID: 6824982
Filing Date: 2004-11-30
Classification: C12Q

Abstract:
A method for determining the enantioselectivity of a process selected from the group consisting of i) kinetic resolutions of chiral substrates and ii) stereoselective reactions with prochiral substrates comprising enantiotopic groups, said method comprising:a) providing at least one chiral substrate or at least one prochiral substrate containing an enantiotopic group, said at least one chiral substrate or at least one prochiral substrate containing an enantiotopic group having an isotope distribution which differs from the natural distribution, or being partially or completely isotope-labeled; b) conducting said process; and c) quantitatively determining any conversion or the relative proportions of any pseudo-enantiomers or any enantiomeric excess using a mass-spectrometric ionization method to give an indication of the enantioselectivity of the process.