Patent ID: 6683072
Filing Date: 2004-01-27
Classification: A61K,A61P

Abstract:
A method of treating irritable bowel syndrome or nonulcer dyspepsia in a subject in need of such treatment, comprising administering to the subject an effective amount of at least one compound of formula I wherein: A is a bridge selected from the following radicals: â€”(CH2)mâ€”, â€”CH=CHâ€”, â€”(CH2)pâ€”Oâ€”, â€”(CH2)pâ€”Sâ€”, â€”(CH2)pâ€”SO2â€”, â€”(CH2)pâ€”NR1â€” and â€”SO2â€”NR2â€”, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R1 is selected from the group consisting of hydrogen and C1-C5 alkyl; and R2 is C1-C5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and Râ€² are independently selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon and the bond designated by  indicates that the absolute conformation about the asymmetric carbon can be either (R) or (S) only when all four groups attached to the asymmetric carbon are nonequivalent, or a pharmaceutically acceptable salt thereof.