Patent ID: 7838524
Filing Date: 2010-11-23
Classification: A61P,C07D

Abstract:
1. A compound of Formula I, or a salt, stereoisomer, alkyl ester prodrug or phenyl(C 1 -C 5 ) alkyl ester prodrug thereof, wherein R (a) hydrogen; (b) (C (c) halogen; A is phenyl, pyridine, or pyrimidine, optionally substituted with 1 or 2 substituents that are independently (C B is phenylene or naphthylene, optionally substituted with 1 to 4 substituents that are independently (C L is a bridging group which is —O—, —S—, or —CH M is phenyl, pyridine or pyrimidine, optionally substituted with 1 to 3 substituents that are independently: (1) (C (2) (C (3) —O—R (4) —NR (5) halogen; (6) —C(O)NR (7) cyano; (8) C(O)R (9) —C≡C—R (10) nitro; n is zero or one and X is: (1) —O—; (2) —SO (3) —NR (4) —NR (5) —N(SO (6) —SO (7) —NR (8) —C(O)—NR (9) —C(O)— or (10) a single bond; Y is a linear or branched C (1) —OR (2) —O—C(O)—R (3) —NR (4) —SO (5) —C(O)—O—R (6) —NH—C(O)—R (7) —C(O)—NR (8) a monocyclic, saturated, partially saturated, or aromatic heterocycle of 5-7 ring atoms containing at least one heteroatom selected from N, O, or S, that is optionally substituted with 1 to 3 substituents selected from (C with the proviso that when n is zero and X is —O—, —NR with the further proviso that when n is zero and X is a single bond, then Z is not —NR R R