Patent ID: 8173806
Filing Date: 2012-05-08
Classification: C07D

Abstract:
1. A method for producing a quinazolin-4-one derivative represented by a general formula (2) by reacting an anthranilic acid derivative represented by a general formula (1) and formamide, wherein the reaction is attained under the condition of coexistence of acetic acid and a base as a catalyst in the reaction liquid: (wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a halogen atom, a nitro group, or a C1-C6 alkyl or alkoxy group; X represents a hydroxyl group, an amino group, or a C1-C6 alkoxy group), and wherein an amount of acetic acid in the reaction liquid is within a range of from 0.1 to 2.0 times by mol the anthranilic acid derivative represented by the general formula (1), the amount of the base in the reaction liquid is within a range of from 0.1 to 2.0 times by mol the anthranilic acid derivative represented by the general formula (1), and the molar ratio of the base to acetic acid is within a range of from 0.2 to 10 times by mol.