Patent ID: 9073973
Filing Date: 2015-07-07
Classification: A61K,A61P,C07K

Abstract:
1. A compound of the general formula wherein is D Pro- L Pro or L Pro- D Pro and Z is a chain of 14 alpha-amino acid residues, the positions of said amino acid residues in the chain being counted starting from the N-terminal amino acid, whereby a N terminus of P1 is attached a C-terminus of said template, and a C-terminus of P14 is attached to a N terminus of said template, whereby these amino acid residues in positions 1 to 14 are: P1: Tyr; P2: Arg; P3: Cit; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Cit; and P14: Lys(Ds1) or P1: Tyr; P2: Arg; P3: Cit; P4: Cys; P5: Arg; P6: Gly; P7: Pro; P8: Dpr(Dsl); P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Cit; and P14: Lys; or P1: Lys(FHS); P2: Arg; P3: Cit; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Cit; and P14: Gln; or P1: Tyr; P2: Arg; P3: Lys(FHS); P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Cit; and P14: Gln; or P1: Tyr; P2: Arg; P3: Thr; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: 2-Nal; P11: Cys; P12: Tyr; P13: Cit; and P14: Lys(FHS); or P1: Tyr; P2: Arg; P3: Thr; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: 2-Nal; P11: Cys; P12: Tyr; P13: Cit; and P14: Lys(FITC); or P1: Tyr; P2: Arg; P3: Cit; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Lys(FHS); and P14: Gln; or P1: Tyr; P2: Lys(FHS); P3: Cit; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Trp; P11: Cys; P12: Tyr; P13: Cit; and P14: Gln; or P1: Tyr; P2: Arg; P3: Thr; P4: Cys; P5: Arg; P6: Gly; P7: Pro; P8: Arg; P9: Arg; P10: 2-Nal; P11: Cys; P12: Tyr; P13: Cit; and P14: Lys(ALX); or P1: His; P2: His; P3: Gln; P4: Cys; PS: Ser; P6: Ala; P7: DPro; P8: Phe; P9: Arg; P10: Tyr; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Leu; P2: His; P3: Thr; P4: Cys; P5: Arg; P6: Ala; P7: P8: Arg; P9: Arg; P10: Tyr; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: His; P2: His; P3: Tyr; P4: Cys; P5: Arg; P6: Ala; P7: P8: Phe; P9: Arg; P10: Phe; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Ser; P2: His; P3: Tyr; P4: Cys; P5: Arg; P6: Ala; P7: P8: Phe; P9: Arg; P10: Phe; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Tyr; P2: Arg; P3: Thr; P4: Cys; P5: Arg; P6: Gly; P7: P8: Arg; P9: Arg; P10: Tyr; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Tyr; P2: Arg; P3: Thr; P4: Cys; PS: Arg; P6: Ala; P7: P8: Arg; P9: Arg; P10: Tyr; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Tyr; P2: Arg; P3: Tyr; P4: Cys; P5: Arg; P6: Ala; P7: P8: Phe; P9: Arg; P10: Phe; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); or P1: Tyr; P2: His; P3: Tyr; P4: Cys; PS: Ser; P6: Ala; P7: P8: Phe; P9: Arg; P10: Tyr; P11: Cys; P12: Tyr; P13: Gln; and P14: Lys(FITC); and pharmaceutically acceptable salts thereof.