Patent ID: 6617357
Filing Date: 2003-09-09
Classification: A61K

Abstract:
A method for inhibiting the enzymatic or catalytic activity of PDE7 in mammals which comprises administering to a mammal in need thereof an effective amount of a compound of Formula 1:wherein,R1 is NRaRb where Ra and Rb are independently H or C1-6 alkyl; R2 is H, C1-8alkyl, C1-3alkyl-Ar, C1-3alkyl-C3-6cycloalkyl, C2-8alkenyl, C2-4alkenyl-Ar, or C2-4alkenyl-C3-6cycloalkyl; Ar is substituted or unsubstituted phenyl; R3 is NO2, halo, CN, C(O)OR7, COR1, or NRaRb where Ra and Rb are independently H or C1-6alkyl; R4 is H, â€”OC1-6alkyl, halo, C(O)NRaRb, C(O)OR7, C1-8alkyl, â€”OCHF2, CH2OR8, â€”OC1-3alkylAr or CH2NH(O)CH3; R5 is H, halo, or alkyl; R6 is C1-8alkyl, OC1-4alkyl or halo; R7 is hydrogen or an ester or amide-forming group; R8 is hydrogen or C1-6alkyl; or a pharmaceuticaly acceptable salt or solvate thereof.