Patent ID: 7947696
Filing Date: 2011-05-24
Classification: A61P,C07D

Abstract:
1. A compound selected from: 2-amino-6-chloro-4-[3-(3-methoxycarbonylpropionylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-trifluoromethylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-methylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-trifluoromethylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-fluorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-chlorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-chlorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-trifluoromethylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-(3 -acetamidophenyl)quinazoline, 2-amino-6-chloro-4-(3 -trifluoroacetamidophenyl)quinazoline, 2-amino-6-chloro-4-(3 -propionylaminophenyl)quinazoline, 2-amino-6-chloro-4-(3 -isobutyrylaminophenyl)quinazoline, 2-amino-6-chloro-4-[3-(pyridin-2-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(pyridin-4-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(pyridin-3-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methoxycarbonylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-fluorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-fluorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-chlorobenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-(3-benzoylaminophenyl)quinazoline, 2-amino-6-chloro-4-[3-(3-aminocarbonylpropionylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(indol-7-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-(3-{3-[(tert-butyloxycarbonyl)amino]propionylamino}1phenyl)-quinazoline, 2-amino-6-chloro-4-(3-{4-[(tert-butyloxycarbonyl)amino]butyrylamino}phenyl)quinazoline, (S)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]propionylamino}phenyl)-quinazoline, (R)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]propionylamino}phenyl)-quinazoline, (S)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-(tert-butoxy)-propionylamino}phenyl)quinazoline, (R)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-(tert-butoxy)-propionylamino}phenyl)quinazoline, (2S)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-(tert-butoxy)butyrylamino }-phenyl)quinazoline, (2R)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-(tert-butoxy)-butyrylamino}phenyl)quinazoline, (S)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-aminocarbonylpropionylamino}phenyl)quinazoline, (R)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-aminocarbonylpropionylamino}phenyl)quinazoline, (S)-2-amino-6-chloro-4-(3-{2-[(tert-butyloxycarbonyl)amino]-3-(1H-imidazol-4-yl)-propionylamino}phenyl)quinazoline, 2-amino-6-chloro-4-[3-(indazol-7-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-hydroxypyridin-4-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[2-(indazol-7-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[2-(2-hydroxypyridin-4-ylcarbonylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-aminopropionylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-aminobutyrylamino)phenyl]quinazoline, (S)-2-amino-6-chloro-4-[3-(2-aminopropionylamino)phenyl]quinazoline, (R)-2-amino-6-chloro-4-[3-(2-aminopropionylamino)phenyl]quinazoline, (S)-2-amino-6-chloro-4-[3-(2-amino-3 -hydroxypropionylamino)phenyl]quinazoline, (R)-2-amino-6-chloro-4-[3-(2-amino-3-hydroxypropionylamino)phenyl]quinazoline, (2S)-2-amino-6-chloro-4-[3-(2-amino-3-hydroxybutyrylamino)phenyl]quinazoline, (2R)-2-amino-6-chloro-4-[3-(2-amino-3-hydroxybutyrylamino)phenyl]quinazoline, (S)-2-amino-6-chloro-4-[3-(2-amino-3-aminocarbonylpropionylamino)phenyl]quinazoline, (R)-2-amino-6-chloro-4-[3-(2-amino-3-aminocarbonylpropionylamino)phenyl]quinazoline, (R)-2-amino-6-chloro-4-[3-(2-amino-3-(1H-imidazol-4-yl)propionylamino)phenyl]-quinazoline, 2-amino-6-chloro-4-[5-fluoro-4-methoxy-2-benzoylaminophenyl]quinazoline, 2-amino-6-chloro-4-(4-chloro-3-{2-[(tert-butyloxycarbonyl)amino]-2-(1H-imidazol-4-yl)-acetamido}phenyl)quinazoline, 2-amino-6-chloro-4-{4-chloro-3-[2-amino-2-(1H-imidazol-4-yl)acetamido]phenyl}-quinazoline, 2-amino-6-chloro-4-{4-chloro-2-[2-amino-2-(1H-imidazol-4-yl)acetamido]phenyll}-quinazoline, 4-{3-[3-(2-amino-7-methylquinazolin-4-yl)-5-chlorophenyl]ureido}benzoic acid, 4-{3-[2-(2-amino-7-methylquinazolin-4-yl)-5-chlorophenyl]ureido}benzoic acid, 2-amino-6-chloro-4-[3-(3-trifluoromethylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[2-(3-trifluoromethylbenzyloxy)phenyl]quinazoline, 2-amino-6-aminocarbonylmethoxy-4-(4-methoxy-3-acetamidophenyl)quinazoline, 2-amino-6-aminocarbonylmethoxy-4-(4-methoxy-2-acetamidophenyl)quinazoline, 2-amino-4-[4-ethoxy-3-(2-hydroxyethoxy)phenyl]-6-[2-(4-methylpiperazin-l-yl)ethoxy]-quinazoline, 2-amino-4-[4-ethoxy-2-(2-hydroxyethoxy)phenyl]-6-[2-(4-methylpiperazin-l-yl)ethoxy]-quinazoline, 2-amino-6-chloro-4-[3-(3-methoxycarbonylpropoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxypropoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[2-(3-carboxypropoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxypropoxy)-5-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[2-(3-carboxypropoxy)-5-methoxyphenyl]quinazoline, 2-amino-6-aminomethylcarbonylamino-4-[3-(3-aminocarbonylpropoxy)phenyl]quinazoline, 2-amino-6-aminomethylcarbonylamino-4-[2-(3-aminocarbonylpropoxy)phenyl]quinazoline, 2-amino-6-chloro-4-{3-[2-(tert-butyloxycarbonylamino)ethoxy]pheny}quinazoline, 2-amino-6-chloro-4-[3-(2-aminoethoxy)phenyl]quinazoline, 2-amino-6-chloro-4-(3-{2-[3-(2-fluorophenyl)ureido]ethoxy}phenyl)quinazoline, methyl {[3-(2-aminoquinazolin-4-yl)-2,4-dichlorophenylcarbamoyl]methoxy}acetate, {[3-(2-aminoquinazolin-4-yl)-2,4-dichlorophenylcarbamoyl]methoxy}acetic acid, {[2-(2-aminoquinazolin-4-yl)-4-chlorophenylcarbamoyl]methoxy}acetic acid, 2-{2-[3-(2-amino-6-chloroquinazolin-4-yl)phenoxy]acetylamino-3-phenylpropionic acid, 2-{2-[2-(2-amino-6-chloroquinazolin-4-yl)-5,6-dichlorophenoxy]acetylamino-3-phenylpropionic acid, 2-amino-6-fluoro-4-[3-(4-methylpiperazin-1-yl)phenyl]quinazoline, 2-amino-6-fluoro-4-[2-(4-methylpiperazin-1-yl)-6-fluorophenyl]quinazoline, 2-amino-6-fluoro-4-[3-(1H-indol-7-ylaminocarbonyl)-4-methoxyphenyl]quinazoline, 2-amino-6-fluoro-4-[2-(1H-indol-7-ylaminocarbonyl)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-methylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-fluorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-fluorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-fluorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-chlorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-chlorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-chlorobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-trifluoromethylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-trifluoromethylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methoxycarbonylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methoxycarbonylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-trifluoromethoxybenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-trifluoromethoxybenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-nitrobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-cyanobenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-cyanobenzyloxy)phenyl]quinazoline, 2-amino-4-[3-(3-trifluoromethylbenzoylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxypropionylamino)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-carboxybenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxybenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-ethoxycarbonylpropoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-fluorobenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-fluorobenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-fluorobenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-trifluoromethylbenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-trifluoromethylbenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-trifluoromethylbenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-difluoromethylbenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-trifluoromethoxybenzyloxy)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-phenylethoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methoxycarbonylbenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methoxycarbonylbenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-fluoro-4-[3-(1H-indol-7-ylaminocarbonyl)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxypropoxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxybenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-carboxybenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-fluoro-4-[3-(1H-indazol-7-ylaminocarbonyl)phenyl]quinazoline, 2-amino-6-fluoro-4-[3-(2-ethoxycarbonyl-1H-indol-7-ylaminocarbonyl)phenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-cyanobenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-cyanobenzyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(pent-4-ynyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(hex-5-ynyloxy)-4-methoxyphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-methoxycarbonylbenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methoxycarbonylbenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-cyanobenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-cyanobenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(1-oxypyridin-4-ylcarbonylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(pyridin-4-ylcarbonylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(1-oxypyridin-3-ylcarbonylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(pyridin-3-ylcarbonylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-methoxycarbonylpropionylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-cyanopropionylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(2-cyanoacetylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(hex-5-ynoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(4-carboxybenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-[3-(3-carboxybenzoylamino)-4-methylphenyl]quinazoline, 2-amino-6-chloro-4-(3,4-dimethoxyphenyl)quinazoline, 2-amino-6-methoxycarbonyl-4-(3,4-dimethoxyphenyl)quinazoline, 2-amino-6-chloro-4-{3-[3-(1H-tetrazol-5-yl)benzyloxy]-4-methoxyphenyl}quinazoline, 2-amino-7-chloro-4-(3,4-dimethoxyphenyl)quinazoline, 2-amino-6-chloro-4-{3-[4-(1H-tetrazol-5-yl)benzyloxy]-4-methoxyphenyl}quinazoline, (S)-2-amino-N-[3-(2-amino-6-chloroquinazolin-4-yl)phenyl]-3-cyanopropionamide, (R)-2-amino-N-[3-(2-amino-6-chloroquinazolin-4-yl)phenyl]-3-cyanopropionamide, 2-amino-6-chloro-4-[3-(5-amino-pentyloxy)phenyl]quinazoline, and