Patent ID: 7129254
Filing Date: 2006-10-31
Classification: A61K,A61P,C07D

Abstract:
1. An effector recognition unit conjugate of formula (I), wherein R  and the other one of R R R R Hal is a halogen atom, R G is an oxygen atom or CH D-E is a group H W is a group C(═X)R L R X is an oxygen atom, R Z is oxygen or is an H and OR R A-Y is O—C(═O), O—CH R PG L the linker of formula (III) has the following structure,  in which T is oxygen or sulfur, U is oxygen, CHR o is 0 to 15, V is a bond, aryl, a group s is 0 to 4, Q is a bond, O—C(═O)—NR R R R and R q is 0 to 15, FG  or CO the linker of formula (IV) has the following structure,  in which T is oxygen or sulfur, W o is 0 to 5, R R R q is 0 to 5, U is oxygen, CHR R R r is 0 to 20, FG  or CO  and wherein at least one group FG FG  and FG a recognition unit is conjugated via a sulfur atom with group FG and wherein the recognition unit is selected from peptides, soluble receptors, cytokines, lymphokines, aptamers, spiegelmers, recombinant proteins, new framework structures, monoclonal antibodies and fragments of monoclonal antibodies; or a single isomer or a mixture of different isomers or a pharmaceutically acceptable salt thereof.