Patent ID: 7332497
Filing Date: 2008-02-19
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) racemic-diastereomeric mixtures, optical isomers or pharmaceutically-acceptable salts thereof wherein: where Z or a group optionally substituted with R 1 selected from the group consisting of alkyl, cycloalkyl, pyrrolidinyl, quinolinyl, quinoxalinyl, quinazolinyl, isoquinolinyl, phthalazinyl, imidazo[1,2-a]pyrimidinyl, 1H-imidazo[1,2-a]imidazolyl, imidazo[2,1-b][1,3]thiazolyl, naphthyl, tetrahydronaphthyl, benzothienyl, furanyl, thienyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, thiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, indolyl, isoxazolyl, tetrahydropyranyl, tetrahydrofuranyl, piperidinyl, pyrazolyl, pyrrolyl, pyrrolopyridinyl, H-pyridinone, oxazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, indolinyl, indazolyl, imidazo[1,2-a]pyridinyl, benzoisothiazolyl, 1,1-dioxybenzoisothiazolyl, pyrido-oxazolyl, pyrido-thiazolyl, pyrimido-oxazolyl, pyrimido-thiazolyl and benzimidazolyl; Z Z R where R Z Z R t for each occurrence is independently an integer from 2 to 6; W for each occurrence is independently a direct bond or O, S, S(O), S(O) R R A is —(C where R for each occurrence is independently H, substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl or substituted or unsubstituted aryl; R p is 1 or 2; or in a phosphorus containing group, the nitrogen atom, the phosphorus atom, R and R A is NRSO Z R wherein E a is 1 and D a is 0, and one of D b is 1 and D b is 0, and one of D n for each occurrence is independently an integer from 0 to 6; provided that when Z provided that when Z