Patent ID: 8455656
Filing Date: 2013-06-04
Classification: A61K,A61P,C07D

Abstract:
1. An ocular implant comprising a tyrosine kinase inhibitor and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the tyrosine kinase inhibitor from the implant for at least about one week after the implant is placed in an eye, wherein the tyrosine kinase inhibitor is provided in an amount from about 40% by weight to about 70% by weight of the implant, and the biodegradable polymer matrix comprises a poly(lactide-co-glycolide) in an amount from about 30% by weight to about 60% by weight of the implant, wherein the implant is formed by an extrusion process, and wherein said tyrosine kinase inhibitor is a compound having the formula: or a pharmaceutically acceptable salt thereof.