Patent ID: 8399248
Filing Date: 2013-03-19
Classification: A61P,C12N,C12Q

Abstract:
1. A method of inhibiting cell division of a mammalian cell comprising introducing into said cell an effective amount of a small interfering nucleic acid (siNA), wherein said siNA comprises a guide strand contiguous nucleotide sequence of 18 to 25 nucleotides and a passenger strand, wherein said guide strand comprises a seed region consisting of nucleotide positions 1 to 12, wherein position 1 represents the 5′ end of said guide strand and wherein said seed region comprises a nucleotide sequence of at least six contiguous nucleotides that is identical to six contiguous nucleotides within a sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:6, SEQ ID NO:9, and SEQ ID NO:31.