Patent ID: 7176288
Filing Date: 2007-02-13
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A variant human Factor VII polypeptide comprising a substitution relative to the sequence of SEQ ID NO:1 selected from the group consisting of: (a) substitution of Lys157 with an amino acid selected from the group consisting of Gly, Val, Ser, Thr, Asp, and Glu; (b) substitution of Lys337 with an amino acid selected from the group consisting of Ala, Gly, Val, Ser, Thr, Gln, Asp, and Glu; (c) substitution of Asp334 with any amino acid other than Ala or Asn; (d) substitution of Ser336 with any amino acid other than Ala or Cys; and (e) combinations of any of the foregoing, wherein the ratio between the activity of the variant and the activity of a Factor VII polypeptide having the sequence of SEQ ID NO:1 is at least about 1.25 when tested in an in vitro hydrolysis assay.