Patent ID: 9089496
Filing Date: 2015-07-28
Classification: A61K,A61P,C12N

Abstract:
1. A pharmaceutical composition comprising an ADHD effective agent complexed with ion-exchange resin particles to form drug-resin particles, wherein said ADHD effective agent is methylphenidate, wherein said composition comprises a first plurality of drug-resin particles that provide for immediate release of said ADHD effective agent and a second plurality of drug-resin particles that are coated with a delayed release coating, said drug-resin particles of said second plurality being coated with a triggered-release coating triggered by a pH change and a diffusion barrier coating, wherein 20%-30% by weight of said methylphenidate is present-in the first plurality of drug-resin particles and 70-80% by weight of said methylphenidate is present in the second plurality of drug-resin particles, and wherein administration of the composition to a human produces a mean plasma concentration profile for d-methylphenidate in human subjects which has one or more parameters selected from the group consisting of AUC