Patent ID: 6153590
Filing Date: 2000-11-28
Classification: A61K,A61P,C07K

Abstract:
A method for treating cancer in a patient in need thereof, comprising administering to said patient an effective amount of a compound of general formula I ##STR41## wherein: R.sub.1 and R.sub.70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group with the proviso that when R.sub.71 is hydrogen as hereinafter described, R.sub.70 is not hydrogen;R.sub.2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R.sub.6 represents a group --CH.dbd. as hereinafter described;R.sub.73 represents a hydrogen atom or an optional substituent or is absent when R.sub.6 represents a methylene group or a group --CH.dbd. as hereinafter described;Y represents an optional substituent;n represents 0, 1, 2, 3, or 4;R.sub.3 represents a hydrogen atom, or an optionally substituted alkyl group;R.sub.74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group;R.sub.7 represents a hydrogen atom or an alkyl group;R.sub.75 represents an optionally substituted alkyl group or --Q'--C(O)X, wherein Q' is an optionally substituted --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 C.dbd.--C-- or phenylene, X is --OR.sub.8, --SR.sub.8, or --NR.sub.9 R.sub.10, and R.sub.8, R.sub.9 and R.sub.10 independently represent a hydrogen atom or an optionally substituted alkyl group; andi) R.sub.6 and R.sub.71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R.sub.72 represents a hydrogen atom; orii) R.sub.71 represents a hydrogen atom or an optionally susbtituted alkyl or acyl group and R.sub.72 represents a hydrogen atom or R.sub.71 and R.sub.72 are joined together such that a double bond is formed between the carbon atoms to which they are attached; andR.sub.6 represents an optionally substituted methylene group bonded to the indole moiety thereby forming a tricyclic moiety; orR.sub.6 represents an optionally substituted group --CH.dbd. bonded to the indole moiety thereby to form an aromatic tricyclic moiety.