Patent ID: 8338415
Filing Date: 2012-12-25
Classification: A61P,C07D,C07F

Abstract:
1. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein X is O or S; Y is selected from the group consisting of O, S, NR and wherein the ring system represented by A in formula V, below, is a 6 membered aryl group, wherein said aryl group is: and wherein the ring system represented by B in formula VI, above, is a five membered unsaturated heterocyclic ring wherein said unsaturated heterocyclic ring is selected from the group consisting of: wherein Z is selected from the group consisting of [C(R 2 ) 2 ] c , O, NR 3a and S; wherein R 1 is —X′-D wherein X′ is selected from the group consisting of and D is selected from a 5 to 6 membered carbocyclic aryl or heterocyclic aryl ring substituted with one or more substituents selected from the group consisting of (CR 3a R 4a ) d′ C(O)OR 2 , (CR 3a R 4a ) d′ C(O)N(R 2 ) 2 , and NR 2 C(O)(CR 3a R 4a ) d′ R 3a ; each R 2 independently is selected from the group consisting of hydrogen, and C 1 to C 8 alkyl; R is (CR 3 R 4 ) d″ R 8 wherein (CR 3 R 4 ) d″ is a 3-7 membered carbocyclic or heterocyclic ring, and R 8 is selected from the group consisting of H, F, C 1 -C 4 alkyl and hydroxy; C 3a and C 4a are independently H or C 1 -C 4 alkyl; R 6a is selected from the group consisting of hydrogen, C 1 -C 8 alkyl, hydroxylmethyl and phenyl; R 7 is selected from the group consisting of hydrogen, and C 1 -C 8 alkyl; a is 1; b is 0; c is an integer of from 1 to 2; d is 0; d′ is 0; and f is 0 or an integer of from 1 to 2; wherein said alkyl radical may be substituted with one or two halo, hydroxy, lower alkyloxy, lower alkyl amino or cycloalkylamino radicals; wherein the cycloalkyl ring can include an enchained oxygen, sulfur or additional nitrogen atom and may be substituted with one or two halo or lower alkyl radicals.