Patent ID: 6025398
Filing Date: 2000-02-15
Classification: A61K,A61P,C07C,C07D,Y02A

Abstract:
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment, comprising intravenously administering to said subject a compound, wherein said compound is a bis-benzamidoxime that is reduced in said subject to produce a benzamidine having anti-P. carinii activity, and wherein said compound is a compound of Formula I: ##STR9## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, lower alkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl or alkylaminoalkyl;R.sub.3 is H, loweralkyl, oxyalkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, aryl, aminoalkyl, alkylaminoalkyl or halogen;n is from 2 to 6;X is O or S; andY is H or lower alkyl;or a pharmaceutically acceptable salt thereof, in an amount effective to treat Pneumocystis carinii pneumonia.