Patent ID: 6906216
Filing Date: 2005-06-14
Classification: C07C

Abstract:
1. A process for the preparation of a β-amino nitrile by the simultaneous ring opening and concomitant N-substitution reaction of a N-tosyl R 1 ,R 2 -aziridine wherein R 1 is selected from the group consisting of alkyl aryl and cycloalkyl, R 2 is selected from the group consisting of H, methyl, ethyl and phenyl, with an aliphatic or aromatic nitrile of the formula R 3 CN wherein R 3 is selected from the group consisting of methyl, ethyl, propyl, butyl, phenyl and benzyl, in the presence of a catalytic amount of metal triflate of the formula M(OTf) x wherein M is a metal, with continuous stirring using a solvent selected from group consisting of the aliphatic or aromatic nitrile as self-solvent, THF, DCM, benzene and toluene under nitrogen atmosphere to obtain N-substituted β-amino nitrile.