Patent ID: 6706893
Filing Date: 2004-03-16
Classification: C07D

Abstract:
A method of making a compound having the formula (C) below: wherein R1, R2, R4, and R5 are, independently, H or a C1 to C6 alkyl or substituted alkyl; and wherein R3 is H or a C1 to C6 alkyl or substituted alkyl; the method comprising reacting an initial compound with hydrogen in the presence of water and a catalyst, the initial compound having the formula (A) or (B) below: wherein R1, R2, R4, and R5 are, independently, H or a C1 to C6 alkyl or substituted alkyl; or wherein R2 and R4 together are replaced by a double bond; R3 is H or a C1 to C6 alkyl or substituted alkyl; and X and Y are, independently, OH, Oâˆ’, or where X and Y together are a bridging oxo; to produce a product mixture comprising a precursor of compound (C); separating the precursor from the catalyst, or from hydrogen, or from both the catalyst and hydrogen, to form a separated precursor; and hydrolyzing the separated precursor.