Patent ID: 9050371
Filing Date: 2015-06-09
Classification: A61K,A61P,C07K

Abstract:
1. A PEGylated insulin lispro compound of the formula: P-[(A)-(B)], or a pharmaceutically acceptable salt thereof, wherein; A is the A-chain of insulin lispro (SEQ ID NO: 1); B is the B-chain of insulin lispro (SEQ ID NO: 3); and P is a PEG having a molecular weight in the range from about 17.5 kDa to about 25 kDa, and wherein A and B contain a disulfide bond between the cysteine at position 7 of A (SEQ ID NO: 1) and the cysteine at position 7 of B (SEQ ID NO: 3), a disulfide bond between the cysteine at position 20 of A (SEQ ID NO: 1) and the cysteine at position 19 of B (SEQ ID NO: 3), and a disulfide bond between the cysteine at position 6 of A (SEQ ID NO: 1) and the cysteine at position 11 of A (SEQ ID NO: 1) and P is attached via a urethane covalent bond to the epsilon-amino group of the lysine at position 28 of B.