Patent ID: 8569237
Filing Date: 2013-10-29
Classification: A61P,C07K

Abstract:
1. A chimeric hirudin protein comprising in this specific order: a carrier protein having a molecular weight equal to or greater than 40 kDa and being physiologically acceptable; a plasmin cleavage site covalently attached through its amino terminus to the carrier protein and consisting of the amino acid sequence of SEQ ID NO:7 or SEQ ID NO: 13; a scissile peptide bond covalently attached to the carboxyl terminus of said plasmin cleavage site; and a latent hirudin covalently and directly attached by its amino terminus to said scissile peptide bond on the carboxyl terminus of said plasmin cleavage site, wherein when cleaved at said scissile peptide bond in the presence of plasmin the latent hirudin is released from said chimeric hirudin protein as activated hirudin.