Patent ID: 8313769
Filing Date: 2012-11-20
Classification: A61K,A61P

Abstract:
1. A process for producing a sheet-like oral dosage form having a corrugated surface that is rapidly disintegrating or soluble in an aqueous environment, where the dosage form comprises a matrix that comprises one or more water-soluble film-forming polymers as base substances and comprises at least one active ingredient, and where the dosage form is provided with spaces or cavities which are present in the polymeric matrix, the contents of said spaces or cavities differing in the state of aggregation from the matrix, comprising: a) preparing a solution or dispersion that comprises at least one water-soluble film-forming polymer and at least one active ingredient, and optionally adding a foam-stabilizing agent; b) foaming the solution or dispersion by decompressing a dissolved gas; c) spreading the foamed solution or dispersion on a coating substrate; and d) solidifying the film by drying and removal of the solvent; thereby obtaining a sheet-like oral dosage form having a corrugated surface provided with spaces or cavities present in a polymeric matrix, that is rapidly disintegrating or soluble in an aqueous environment, the contents of said spaces or cavities differing in their state of aggregation from the matrix and at least one active substance being included in the matrix.