Patent ID: 6831175
Filing Date: 2004-12-14
Classification: C07D

Abstract:
A compound of formula (I) or a therapeutically acceptable salt thereof, whereinX is selected from the group consisting of C(R8) and N; wherein R8 is selected from the group consisting of hydrogen, alkyl, amino, carboxy, cyano, halo, hydroxy, and amido; Xâ€² is selected from the group consisting of C and N; Y is C; Yâ€² is C(R9); wherein R9 is selected from the group consisting of hydrogen and -L2-L3(R3)(R6); Z is C; provided that X or Xâ€² is N, and provided that both X and Xâ€² are not N; L1 is selected from the group consisting of a bond, â€”Oâ€”, â€”NR5â€”, alkenyl, alkynyl, â€”C(O)â€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”S(O)2N(R5)â€”, â€”N(R5)S(O)2â€”, â€”C(R12)2â€”, â€”C(R12)2N(R5)â€”, â€”N(R5)C(O)â€”, and â€”C(O)N(R5)â€”; wherein each group is drawn with its left end attached to R1 and its right end attached to the aromatic ring; L2 is selected from the group consisting of a bond, â€”Oâ€”, â€”C(R12)2â€”, â€”Sâ€”, â€”N(R5)â€”, â€”N(R5)C(O)â€”, and â€”C(O)N(R5)â€”; L3 is selected from the group consisting of a bond, alkylidene and alkylene, wherein the alkylidene and the alkylene are optionally substituted with one or two substituents independently selected from the group consisting of alkoxy, amino, cyano, and hydroxy, with the proviso that if L2 is a bond, â€”Oâ€”, or â€”Sâ€” then L3 is not a bond; R1 is selected from the group consisting of monocyclic or bicyclic aryl, heteroaryl, and heterocycle; R2 and R4 are independently absent or selected from the group consisting of hydrogen, alkenyl, alkyl, alkynyl, amino, aryl, arylalkynyl, cyano, cyanoalkenyl, halo, heteroaryl, heterocycle, hydroxyalkyl, and nitro; or R2 and L1, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; or R4 and L2, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; provided that when L3 is alkylidene, R4 and L2, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; R3 is absent or selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylamino, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle; R6 is selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylamino, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle; provided that when L1 and L2 are bonds, at least one of R3 and R6 other than hydrogen; R5 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl, and heteroarylsulfonyl; R7 is absent or selected from the group consisting of hydrogen, alkyl, cyanoalkenyl, and -L2-L3(R3)(R6); or R7 and L1, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; and each R12 is selected from the group consisting of hydrogen, alkenyl, alkyl, alkynyl, amino, aryl, cyano, halo, heteroaryl, heterocycle, and nitro.