Patent ID: 6632816
Filing Date: 2003-10-14
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of formula I and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof,wherein n is 3 or 4, wherein X and Y, the same or different, are selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, F, Cl, Br, I, â€”CF3, â€”OCF3, â€”CN, â€”NO2, â€”NR4R5, â€”NHCOR4, â€”OR4, â€”SR4, â€”COOR4, â€”COR4, and â€”CH2OH or X and Y together define an alkylenedioxy group selected from the group consisting of a methylenedioxy group of formula â€”OCH2Oâ€” and an ethylenedioxy group of formula â€”OCH2CH2Oâ€”, wherein R1 is selected from the group consisting of a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkylalkyl group having 3 to 6 carbon atoms in the cycloalkyl part thereof and 1 to 3 carbon atoms in the alkyl part thereof, wherein R2 is selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, and a group of formula R2Aâ€”COâ€”, R2A being selected from the group consisting of a straight or branched alkyl group of 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a cycloalkylalkyl group having 3 to 6 carbon atoms in the cycloalkyl part thereof and 1 to 3 carbon atoms in the alkyl part thereof, an alkyloxy group of 1 to 6 carbon atoms, tetrahydro-3-furanyloxy, â€”CH2OH, â€”CF3, â€”CH2CF3, â€”CH2CH2CF3, pyrrolidinyl, piperidinyl, 4-morpholinyl, CH3O2Câ€”, CH3O2CCH2â€”, Acetyl-OCH2CH2â€”, HO2CCH2â€”, 3-hydroxyphenyl, 4-hydroxyphenyl, 4-CH3OC6H4CH2â€”, CH3NHâ€”, (CH3)2Nâ€”, (CH3CH2)2Nâ€”, (CH3CH2CH2)2Nâ€”, HOCH2CH2NHâ€”, CH3OCH2Oâ€”, CH3OCH2CH2Oâ€”, C6H5CH2Oâ€”, 2-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl-, 2-pyrazinyl, 2-quinolyl, 3-quinolyl, 4-quinolyl, 1-isoquinolyl, 3-isoquinolyl, 2-quinoxalinyl, a phenyl group of formula a picolyl group selected from the group consisting of a picolyloxy group selected from the group consisting of a substituted pyridyl group selected from the group consisting of a group selected from the group consisting of wherein Xâ€² and Yâ€², the same or different, are selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, F, Cl, Br, I, â€”CF3, â€”NO2, â€”NR4R5, â€”NHCOR4, â€”OR4, â€”SR4, â€”COOR4, â€”COR4 and â€”CH2OH, wherein R4 and R5, the same or different, are selected from the group consisting of H, a straight alkyl group of 1 to 6 carbon atoms, a branched alkyl group of 3 to 6 carbon atoms, and a cycloalkyl group of 3 to 6 carbon atoms, wherein R3 is selected from the group consisting of a diphenylmethyl group of formula IV a naphthyl-1-CH2â€” group of formula V a naphthyl-2-CH2â€” group of formula VI a biphenylmethyl group of formula VII and an anthryl-9-CH2â€” group of formula VIII