Patent ID: 8961991
Filing Date: 2015-02-24
Classification: A61K,A61P,C07K,C12N,G01N,Y02A

Abstract:
1. A fusion protein comprising the formula: Ab-(Ag-PL-Ag)x; wherein Ab is an antibody or fragment thereof comprising at least the variable region of the antibody anti-CD40_12B4.2C10 (ATCC Submission No. HS446, Accession No. PTA-10653) or of the antibody anti-CD40_11B6.1C3 (ATCC Submission No. HS440, Accession No. PTA-10652); wherein PL is at least one peptide linker comprising at least one glycosylation site; wherein Ag is at least one antigen, at least one of which is SEQ ID NO:5; and wherein x is an integer from 1 to 20, the fusion protein having more stability in solution than the same fusion protein without the glycosylation site.