Patent ID: 6054325
Filing Date: 2000-04-25
Classification: B01J,B01L,C40B,Y10T

Abstract:
A method for combining distinct chemical compositions with reagents, the method comprising:providing a plurality of solid supports having the chemical compositions thereon;organizing the solid supports having the chemical compositions thereon into separate regions of a donor member so that each region includes a distinct chemical composition, wherein the donor member regions each include a liquid medium, wherein the donor member regions each have a bottom end with a hole extending therethrough, and wherein the bottom ends slope toward the holes;releasing at least some of the chemical compositions from their solid supports and into the liquid medium while within the donor member regions;applying centrifugation to the donor member to systematically transfer at least some of the liquid medium containing the released chemical compositions through the holes and into individual locations within an acceptor member such that the locale of each transferred chemical composition within the acceptor member is known, and wherein the individual locations define a volume that is less than about 500 .mu.l; andintroducing a reagent to each location having one of the chemical compositions.