Patent ID: 6221395
Filing Date: 2001-04-24
Classification: A61K

Abstract:
A pharmaceutical tablet for oral administration, able to release under controlled speed, nifedipine, said tablet, consisting essentially of at least one first layer obtained by compression of a mixture of ingredients in the form of a powder or granulate, said first layer comprising 9% to 80% by weight of nifedipine based on the total weight of said first layer, said first layer further comprising sodium lauryl sulfate at a ratio of 6:1 by weight of the nifedipine and 3% to 90% of hydroxypropylmethylcellulose having a viscosity of 100,000 cps; one or more barrier layers which comprise from 5% to 90% of a component selected from the group consisting of pharmaceutically acceptable and biocompatible polymeric substances, based on the total weight of said barrier layer or layers having either the properties to swell or to form gels or slowly erode in contact with water or aqueous fluids and which control the release of the active principle, and a coating layer which completely covers said at least one first layer and said barrier layer, said coating layer comprising a copolymer which comprises acrylic and methacrylic acid.