Patent ID: 7595185
Filing Date: 2009-09-29
Classification: C12N

Abstract:
1. A recombinant cell comprising, a gene coding for cytotoxin polypeptide of a proteic killer gene system and a gene coding for an antidote polypeptide of said proteic killer gene system, wherein said antidote polypeptide is capable of binding said cytotoxin polypeptide, thereby at least partially counteracting the toxic effect of said cytotoxin polypeptide, wherein the gene coding for the toxic polypeptide and the gene coding for the antidote polypeptide are under the control of regulatory sequences, wherein the gene coding for the antidote polypeptide is operably linked to a regulatory sequence that is different from the regulatory sequence controlling the gene coding for the cytotoxin polypeptide and wherein the gene coding for the cytotoxin polypeptide is located in the chromosome of the cell.