Patent ID: 6586422
Filing Date: 2003-07-01
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula whereinR1 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, or unsubstituted phenyl or phenyl substituted in meta or para positions with at least one substituent selected from the group consisting of lower alkyl, lower alkoxy or halogen; or is absent, when X is â€”N&boxH; or &boxH;Nâ€”; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, â€”O, â€”S-lower alkyl, â€”SO2-lower alkyl or â€”OR, â€”O(CHRa)m+1â€”ORb, NRc2, â€”NHâ€”NRd2, â€”N(Re)(CHRf)m+1â€”ORg, â€”N(Rh)(CHRi)m-pyridino, â€”N(Ri)(CHRk)nâ€”(C3-C6)cycloalkyl, â€”N(Rl)(CHRm)m(CRn2)â€”NRo2, or â€”N(Rp)(CHRq)m+1â€”NHâ€”C(O)â€”O-lower alkyl; m is 1, 2, 3, 4, 5 or 6; n is 0, 1, 2, 3, 4 or 5; R, Ra-q are each independently selected from the group consisting of hydrogen, lower alkyl or lower alkenyl; X is selected from the group consisting of â€”N&boxH;, &boxH;Nâ€”, >O&boxH; or &boxH;O2 is &boxH;O, or lower alkenyl, Y is selected from the group consisting of â€”CH&boxH;CHâ€”, â€”CH&boxH;OR3â€”, â€”OR3&boxH;CHâ€”, CR3&boxH;CR4â€” or S; and R3, R4 are, independently, selected form the group consisting of hydrogen, lower alkyl, lower alkoxy or halogen with the proviso, that when Y represents a vinylene group, only one group R3 and one group R4 may be present in the resultant benzene ring; or a pharmaceutically acceptable salt thereof in racemic and optically active form.