Patent ID: 6893645
Filing Date: 2005-05-17
Classification: A61K

Abstract:
1. A process for making Compound (I), where Compound (I) comprises Compound (A), and a polymer, wherein the polymer comprises lactide units, glycolide units and tartaric acid units where the ratio in the polymer of the lactide units is from and including 71% to 73%; of the glycolide units is from and including 26% to 28%; and of the tartaric acid units is from and including 1% to 3%; and where the amino group of Compound (A) is ionically bonded to a carboxylic group of the acid units of the polymer; said process comprising the step of reacting an aqueous solution of Compound (A) with the polymer or a salt thereof, in a mixture of acetonitrile and water wherein the weight ratio of acetonitrile to water is about 3 to 1, respectively, at a temperature of about 0° C. to 5° C. until the formation of Compound (I) is substantially complete.