Patent ID: 8986694
Filing Date: 2015-03-24
Classification: C07K

Abstract:
1. A method of treating pain in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a human Nav1.7 protein that comprises a mutation selected from the group consisting of: 1161W, 1919G, 490N, 1002L, 422D and 943L in SEQ ID NO: 75; wherein the antibody or antibody fragment comprises a human gamma-2 heavy chain constant region that comprises an amino acid selected from the group consisting of: wherein said human comprises (i) an IGHG2*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-2 heavy chain constant regions comprising said selected amino acid; (ii) said human comprises a nucleotide sequence encoding said Nav1.7 protein comprising said selected mutation in SEQ ID NO: 75.