Patent ID: 7687624
Filing Date: 2010-03-30
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula I in which X denotes R R R R R Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms which is unsubstituted or mono- or disubstituted by Hal, A, OR A′ denotes unbranched or branched alkyl having 1-6 C atoms, A denotes unbranched, branched or cyclic alkyl having 1-12 C atoms, in which one or two CH Hal denotes F, Cl, Br or I, n denotes 0, 1 or 2, m denotes 0, 1, 2, 3 or 4, and salts thereof, characterised in that a) a compound of the formula II which has a pK in which X has the meaning indicated above, is reacted with 5-chloro-2,3-dihydro-1,4-dioxin to give a compound of the formula III in which X has the meaning indicated above, b) then a compound of the formula III is cyclised to give a compound of the formula I, and c) the latter is optionally converted into its salt by converting a base or acid of the formula I into one of its salts.