Patent ID: 6448415
Filing Date: 2002-09-10
Classification: C07D

Abstract:
A process for converting the chirality of 4- or 5-position carbon in a compound represented by the following formula (1): whereinn denotes a number of 0 or 1, R1, R2 and R3 independently of one another represent hydrogen, fluorine, straight-chain or branched C1-C6-alkoxy, C2-C6-carbonyloxy, benzoyloxy or benzyloxy, or two of them may combine to form isopropylidenedioxy or cyclohexylidenedioxy, Q represents R4 and R5 independently of one another represent hydrogen, straight-chain or branched C1-C6-alkoxy, C2-C6-carbonyloxy, benzoyloxy or benzyloxy, or may combine to form isopropylidenedioxy or cyclohexylidenedioxy, and R6 represents straight-chain or branched C1-C6-alkoxy, C2-C6-carbonyloxy, benzoyloxy or benzyloxy, which comprises reacting the compound of formula (1) with a secondary amine represented by the following formula (2): whereinRâ€² and Râ€³ are identical or different and independently of one another represent straight-chain or branched C1-C6-alkyl, or together with the nitrogen atom to which they are attached may form 4- to 7-membered saturated hetero cycle, and then reacting the resulting compound with a sulfonyl group- containing compound represented by the following formula (3): whereinR represents straight-chain or branched C1-C6-alkyl, phenyl or tolyl, and L represents halogen or