Patent ID: 9222945
Filing Date: 2015-12-29
Classification: C12Q,G01N

Abstract:
1. A method for identifying chronic mammalian wound tissue or for determining the prognosis of mammalian wound tissue, which method comprises: (a) examining a sample of wound tissue from an individual to determine the levels of expression of genes encoding molecular markers selected from the set of molecular markers consisting of: ARP2, CREBL1, VEGF-C, Psoriasin, IL22R, TEM4, IL8RB, IL17BR, Claudin-5, KaI1, PTPRK, CAR1, Endomucin-2, and TEM7R; Psoriasin: SEQ ID NO: 37, SEQ ID NO: 38; Claudin-5: SEQ ID NO: 21, SEQ ID NO: 22; IL8RB: SEQ ID NO: 19, SEQ ID NO: 20; IL22R: SEQ ID NO: 15, SEQ ID NO: 16; PTPRK: SEQ ID NO: 25, SEQ ID NO: 26; TEM4: SEQ ID NO: 41, SEQ ID NO: 42; TEM7R: SEQ ID NO: 23, SEQ ID NO: 24; VEGF-C: SEQ ID NO: 7, SEQ ID NO: 8; ARP2: SEQ ID NO: 1, SEQ ID NO: 2; CAR1: SEQ ID NO: 47, SEQ ID NO: 48; Endomucin: SEQ ID NO: 13, SEQ ID NO: 14; IL7BR: SEQ ID NO: 43, SEQ ID NO: 44; KaI1: SEQ ID NO: 45, SEQ ID NO: 46; and CREBL1: SEQ ID NO: 49, SEQ ID NO: 50; and (b) the following genes show decreased expression relative to control tissue: ARP2, CREB1l, VEGF-C, IL8RB, IL17BR, Claudin-5, CAR1 and Endomuscin-2, and; (c) TEM 4 shows normal expression relative to control tissue; and (d) the following genes show increased expression relative to control tissue: Psoriasin, IL22R, KAI1, PTPRK, and TEM7R.