Patent ID: 6667338
Filing Date: 2003-12-23
Classification: C07H

Abstract:
A compound of formula (I) and a compound of formula (II) or a therapeutically acceptable salt or prodrug thereof, whereinR1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, and (heterocycle)alkynyl, provided that R1 is not hydrogen in compounds of formula (II); R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkanoyl, alkoxy, alkoxycarbonyl, alkylsulfonyl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkyloxycarbonyl, cycloalkyloyl, cycloalkylsulfonyl, cycloalkylaminocarbonyl, cycloalkylthiocarbonyl, aryl, arylalkyl, aroyl, aryloxycarbonyl, arylsulfonyl, alkylaminocarbonyl, alkylthiocarbonyl, arylaminocarbonyl, arylthiocarbonyl, heterocycle, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, (heterocycle)carbonyl, (heterocycle)aminocarbonyl, (heterocycle)oxycarbonyl, (heterocycle)thiocarbonyl, (heterocycle)sulfonyl, hydroxyl, and a nitrogen protecting group; or R1 and R2 together are selected from the group consisting of â€”C(O)â€”, â€”CH2CH&boxH;CHCH2â€”, alkylene, â€”CH2C(O)â€”, and â€”C(O)CH2â€”, wherein for â€”CH2C(O)â€” and â€”C(O)CH2â€”, each group is drawn with its left end attached to the nitrogen and its right end attached to the oxygen; or R2 and R3 taken together with the nitrogen atom to which they are attached form a heterocycle; R4 and R5 are hydrogen; or R3 and R4 together are selected from the group consisting of â€”C(O)â€”, â€”CH2CH&boxH;CHCH2â€”, alkylene, â€”CH(R7)â€”, â€”(CH2)mC(O)â€”, and â€”C(O)(CH2)mâ€”, wherein m is an integer ranging from 1 to 4, and wherein for â€”(C2)mC(O)â€” and â€”C(O)(CH2)mâ€”, each group is drawn with its left end attached to the nitrogen and its right end attached to the oxygen; or R4 and R5 together are selected from the group consisting of â€”CH(R7)â€” and â€”C(O)â€”, provided that, for compounds of formula (I), when R4 and R5 are hydrogen and either R2 or R3 is alkanoyl, R1 is other than hydrogen, and for compounds of formula (I), when R2, R3, R4, and R5 are hydrogen, R1 is other than hydrogen; R6 is selected from the group consisting of hydrogen, alkanoyl, alkyl, aryl, carboxamido, and (heterocycle)carbonyl; R7 is selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, arylalkyl, (heterocycle)alkyl and cycloalkyl; and Rp is selected from the group consisting of hydrogen, trimethylsilyl, arylalkyl, aroyl, and alkanoyl.