Patent ID: 6040296
Filing Date: 2000-03-21
Classification: A61K,A61P,C07H,C12N

Abstract:
A pharmaceutical composition, comprisingan oligonucleotide (oligo) in aerosol form, which is effective for alleviating bronchoconstriction or lung inflammation when administered to a mammal, the oligo being antisense to the initiation codon region, the coding region, the 5' or 3' intron-exon junctions or regions within 2 to 10 nucleotides of the intron-exon junctions of a gene encoding an adenosine A.sub.1 receptor or a gene encoding an adenosine A.sub.3 receptor, or antisense to an adenosine A.sub.1 receptor mRNA or an adenosine A.sub.3 receptor mRNA; anda pharmaceutically acceptable carrier.