Patent ID: 6559145
Filing Date: 2003-05-06
Classification: A61P,C07D

Abstract:
A compound of formula I, wherein,X is Cl, Br, F, CN, or NO2; G is (a) C0-4alkyl which is fully saturated or partially unsaturated and is substituted by hydroxy, or (b) C1-4alkyl substituted by NR1R2 or 4-tetrahydropyran; R1 is C2-7alkyl substituted by hydroxy, C1-4alkoxy, heteroaryl, or aryl; R2 is hydrogen or C1-7alkyl; or R1 and R2 together with the nitrogen to which they are attached form morpholine which may be optionally substituted by aryl or C1-7alkyl; or pyrrolidine substituted by hydroxy; W is a heterocycle of formula W3.1R4 is H, halo, or C1-4alkyl optionally substituted by one to three halogens; R6 is (a) H, (b) halo, (c) aryl, (d) het, (e) OR12, (f) SR12, (g) C1-7alkyl which may be partially unsaturated and optionally substituted by one or more substituents selected from OR12, SR1, NR10R11, aryl, halo, C3-8cycloalkyl optionally substituted by OR12, or het attached through a carbon atom, (h) NR10OR11, (i) C3-8cycloalkyl which may be partially unsaturated and is optionally substituted by one or more substituents selected from halogen, OR12, SR1, NR10R11, (j) (C&boxH;O)R9, (k) S(O)mR9, (l) (C&boxH;O)OR2, (in) NHSO2R9, (n) nitro, or (o) cyano; R7 is (a) C1-7alkyl which may be partially unsaturated and optionally substituted by one or more substituents selected from OR12, SR1, NR10R11, or halo, (b) C3-8cycloalkyl which may be partially unsaturated and is optionally substituted by one or more substituents selected from halogen, OR12, SR1, NR10R11, (c) aryl, or (d) het; R8 is (a) H, (b) C1-7alkyl which may be partially unsaturated and optionally substituted by one or more substituents selected from OR12, SR1, NR10R11, or halo, (c)OR12, or (d) SR12; R9 is (a) C1-7alkyl, (b) NR10R11, (c) aryl, or (d) het, wherein said het is bound through a carbon atom; R10 and R11 are independently (a) H, (b) aryl, (c) C1-7alkyl which may be partially unsaturated and is optionally substituted by one or more substituents selected from CONR2R2, CO2R2, het, aryl, cyano, or halo, (d) C2-7alkyl which may be partially unsaturated and is substituted by one or more substituents selected from NR2R2, OR2, or SR2, (e) C3-8cycloalkyl which may be partially unsaturated and is optionally substituted by one or more substituents selected from halogen, OR2, SR2, or NR2R2, or (f) R10 and R11 together with the nitrogen to which they are attached form a het; R12 is (a) H, (b) aryl, (c) het (d) C1-7alkyl optionally substituted by aryl, or halogen, (e) C2-7alkyl substituted by OR2, SR2, or NR2R2, or (f) C3-8cycloalkyl which may be partially unsaturated and is optionally substituted by one or more substituents selected from halogen, OR2, SR2, or NR2R2; each m is independently 1 or 2; aryl is a phenyl radical or an ortho-fused bicyclic carbocyclic radical wherein at least one ring is aromatic, and aryl maybe optionally substituted with one or more substituents selected from halo, OH, cyano, NR2R , CO2R2, CF3, C1-6alkoxy, and C1-6alkyl which maybe further substituted by one to three SR2, NR2R2, OR2, or CO2R2 groups; het is a four- (4), five- (5), six- (6), or seven- (7) membered saturated or unsaturated heterocyclic ring having 1, 2, or 3 heteroatoms selected from oxygen, sulfur, or nitrogen, which is optionally fused to a benzene ring, or any bicyclic heterocycle group, and het may be optionally substituted with one or more substituents selected from halo, OH, cyano, phenyl, CO2R2, CF3, C1-6alkoxy, oxo, oxime, and C1-6alkyl which may be further substituted by one to three SR2, NR2R2, OR2, or CO2R2 groups; halo or halogen is F, Cl, Br, I; 1 represents the point of attachment between W and G; 2 represents the point of attachment between W and the carbonyl group of Formula (I); and a pharmaceutically acceptable salt thereof.