Patent ID: 7332335
Filing Date: 2008-02-19
Classification: A61K,A61P,C12N

Abstract:
1. A method of activating p53 to increase expression of p21 WAF1/Cip 1 in cells, the method comprising: selecting cells for decreasing levels of PP5 protein; exposing the cells to a compound which decreases levels of PP5 protein in cells in vitro, wherein the compound is an antisense oligonucleotide having a nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:8, and SEQ ID NO:9 or an inhibitor of the PP5 protein and; measuring the levels of PP5 protein in the cells, measuring inhibition of the PP5 protein or measuring proliferation of the cells.