Patent ID: 6750332
Filing Date: 2004-06-15
Classification: A61K,A61Q,C07H,C08B,C12P

Abstract:
A salicyl alcohol derivative of the formula (I):R1â€”OCH2â€”Phâ€”Oâ€”Zâ€”(R2)nâ€ƒâ€ƒ(I) wherein R1 represents a hydrogen atom or a C(O)R3 group, wherein R3 represents an alkyl, cycloalkyl, cycloalkylalkyl, aralkyl or aryl group having from 1 to 26 carbon atoms and/or from 1 to 10 heteroatoms, and wherein R3 may be unbranched or branched, mono- or polyunsaturated and/or may bear substituents on the carbon chain and/or at the heteroatoms; Ph represents a 1,2-phenylene group, Z represents a sugar hemiacetally attached to the 1,2-phenylene group and substituted up to n-times by R2, wherein the sugar may comprise a mono, di-, oligo- or polysaccharide; n is an integer between 0 and m, wherein m is equal to the number of free hydroxyl groups present in the sugar; wherein each R2 independently represents a hydrogen atom or a C(O)R4 group wherein R4 is independently selected from the same group as R3; R1 and R2 may be the same or different; with the proviso that at most one of the two substituents R1 or R2 is hydrogen when Z is glucose; with the proviso that where Z is glucose and R2 is hydrogen, R1 is not an acetyl, a benzoyl or a (1-hydroxy-6-oxo-2-cyclohexen-1-yl)carbonyl; with the proviso that where R1 is hydrogen, Z is glucose and n equals 1, the glucose unit is substituted by R2 at its primary hydroxy group and R2 is not 4-phenylbutyryl or a hydrophobic aromatic carboxylic acid moiety.