Patent ID: 8980957
Filing Date: 2015-03-17
Classification: C08F,G02B,Y10S

Abstract:
1. A method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions comprising the steps of (a) preparing a polymerization mixture comprising at least two monomers, of which the first monomer is 2-methylated, 2,3-dimethylated or unmethylated maleic acid anhydride, or substituted or unsubstituted vinylic or acrylic phthalic acid anhydride and the second or further monomer is a different monomer having at least one ethylenically unsatured group, the polymerization mixture optionally further including one or both of a free radical initiator and a cross-linking agent having a plurality of ethylenically unsaturated groups; (b) inducing polymerization; and (c) upon completion of the polymerization reaction, exposing the polymer formed to L-lysine under basic conditions for amidating substantially all succinylic anhydride groups present in the polymer, wherein the second and further monomer comprise combinations of monomers capable of forming a hydrogel, selected from the group consisting of hydroxyethylmethacrylate and methyl methacrylate, vinyl pyrrolidone and hydroxyethylmethacrylate, vinyl pyrrolidone and methyl methacrylate, glycerol methacrylate and methyl methacrylate, glyceryl-methacrylate and 2-hydroxyethyirnethacrylate, hydroxyethylmethacrylate or diacetone acyl amide and hydroxyalkyl methacrylates, hydroxyethylmethacrylate or diacetone acyl amide and acrylates with the alkyl groups having from 2 to 6 carbon atoms, hydroxyethylmethacrylate or diacetone acyl amide and vinyl hydroxy acetate, hydroxyethylmethacrylate or diacetone acyl amide and vinyl hydroxy propionate, hydroxyethylmethacrylate or diacetone acyl amide and vinyl hydroxy butyrate, hydroxyethylmethacrylate or diacetone acyl amide and a N-vinyl lactams, hydroxyethylmethacrylate or diacetone acyl amide and N,N dialkyl amino ethyl methacrylates and acrylates with the alkyl groups having from 0 to 2 carbon atoms, hydroxyethylmethacrylate or diacetone acyl amide and hydroxyalkyl vinyl ethers with the alkyl groups having 2 to 4 carbon atoms, hydroxyethylmethacrylate or diacetone acyl amide and 1-vinyloxy 2-hydroxyethylene, hydroxyethylmethacrylate or diacetone acyl amide and 1-vinyloxy 5-hydroxy 3-oxapentane, hydroxyethylmethacrylate or diacetone acyl amide and 1-vinyloxy 8-hydroxy 3,6-dioxaoctane, hydroxyethylmethacrylate or diacetone acyl amide and 1-vinyloxy 14-hydroxy 3,6,9,12 tetraoxatetradectane, hydroxyethylmethacrylate or diacetone acyl amide and N-vinyl morpholine; hydroxyethylmethacrylate or diacetone acyl amide and N,N dialkyl acrylamide with the alkyl groups having from 0 to 3 carbons atoms, hydroxyethylmethacrylate or diacetone acyl amide and alkyl vinyl ketone with the alkyl group having 1 to 2 carbon atoms, hydroxyethylmethacrylate or diacetone acyl amide and N-vinyl succinimide or N-vinyl glutarim ide, hydroxyethylmethacrylate or diacetone acyl amide and N-vinyl imidazole, and hydroxyethylmethacrylate or diacetone acyl amide and N-vinyl 3-morpholinone.