Patent ID: 7556965
Filing Date: 2009-07-07
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for reducing the antigenicity, relative to wild-type AAV, of an AAV capsid, the method comprising introducing at least one modification into a structural protein of AAV, the structural protein being selected from the group consisting of AAV VP1, VP2, and VP3, wherein the modification brings about a reduction in the antigenicity of the capsid, relative to wild-type AAV and wherein the modified structural protein forms capsids, and wherein the modification(s) is/are located directly adjacent to at least one amino acid in a sequence selected from the group consisting of YKQIS SQSGA (SEQ ID NO: 2), YLTLN NGSQA (SEQ ID NO: 3), YYLSR TNTPS (SEQ ID NO: 4), EEKFF PQSGV (SEQ ID NO: 5), NPVAT EQYGS (SEQ ID NOS: 6, 7), LQRGN RQAAT (SEQ ID NO: 8), and NVDFT VDTNG (SEQ ID NO: 9).