Patent ID: 8206621
Filing Date: 2012-06-26
Classification: A61K,A61L,A61P

Abstract:
1. PLGA plasticized with ethanol, obtained by a process comprising the following steps: a) grinding PLGA to obtain a ground product in which the particles have dimensions less than 250 μm; b) adding ethanol to the ground product obtained in the preceding step in concentrations between 5 and 20 parts by weight/weight of PLGA and heating the mixture obtained to a temperature between 45 and 65° C., until a viscous and stable gel is obtained; c) drying the product coming from step (b), d) grinding the dried product obtained at a temperature ranging from −20 and +5° C.; f) extruding the aforesaid product at 75° C., and g) grinding the extruded product at a temperature between −20° C. and +5° C., said process optionally comprising a step e), to be performed before step f), of mixing the product coming from step d) with untreated PLGA, which has been previously ground until a ground product of particle size less than 250 μm is obtained, in a weight ratio of product coming from step d)/untreated PLGA between 10:90 and 99:1, at a temperature between −20 and +5° C.