Patent ID: 8940488
Filing Date: 2015-01-27
Classification: C07K,G01N

Abstract:
1. A method for diagnosing cancer comprising the steps of: (a) collecting a test sample selected from blood, serum or plasma from a subject, (b) contacting an anti-ROBO1 antibody which binds to 1-898 of the amino acid sequence of SEQ ID NO: 9 or 1-859 of the amino acid sequence of SEQ ID NO: 11 to the test sample, (c) detecting a first complex comprising the anti-ROBO1 antibody, (d) contacting a control sample selected from blood serum or plasma from a healthy subject with an anti-ROBO1 antibody which binds to 1-898 of the amino acid sequence of SEQ ID NO: 9 or 1-859 of the amino acid sequence of SEQ ID NO: 11, (e) detecting a second complex comprising the anti-ROBO1 antibody, (f) comparing the level of the first complex detected in step (c) to the level of the second complex detected in step (e), and (g) diagnosing the subject as having cancer when the level of the first complex is higher than the level of the second complex; and wherein the cancer is selected from the group consisting of, breast cancer, gastric cancer, hepatic cancer, large intestine cancer, and lung cancer.