Patent ID: 8716293
Filing Date: 2014-05-06
Classification: A61P,C07D

Abstract:
1. A compound having formula I or a stereochemically isomeric form thereof, wherein, R 1 is F or Cl; R 2 is H, F or Cl; R 3 is C 1-4 alkyl, C 1-4 alkoxyC 1-4 alkyl, cyclopropyl or tetrahydrofuranyl; R 4 is hydrogen or methyl; J is —N(R 5 )—SO 2 —, —C(═O)—N(R 5 )—, —N(R 5 )—, wherein the dashed line denotes the point of attachment to the pyridazinone ring; K is —(CHR 6 ) p —, *-(CH 2 ) q —CH═CH—CH 2 — or *-(CH 2 ) q —CH≡CH—CH 2 — wherein * denotes to point of attachment to the J moiety; L is —O—, —O—CH 2 -* or —N(R 5 )—C(═O)-* wherein * denotes the point of attachment to the phenyl ring; and, R 5 is hydrogen, C 1-4 alkyl or C 3-5 cycloalkyl; each R 6 independently is hydrogen or C 1-3 alkyl; p is 3, 4, 5 or 6; q is 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.