Patent ID: 6328762
Filing Date: 2001-12-11
Classification: A61F,A61K,A61L,C07K,C12N

Abstract:
A prosthetic graft for containment of blood flow in vivo, comprising:(a) a porous prosthetic implant for containing blood in vivo, said prosthetic implant having an outer surface that is not in contact with blood flow in vivo and an inner surface that is in contact with blood flow in vivo, said inner surface defining an interior space for containment of blood flow; and,(b) adherent cells adhered to the outer surface of said porous prosthetic implant, wherein said adherent cells are transfected with at least one recombinant nucleic acid molecule operatively linked to a transcription control sequence, said recombinant nucleic acid molecule encoding a protein wherein at least a portion of said protein, upon secretion from said cells, perfuses through pores of said prosthetic implant to said inner surface of said prosthetic implant, enhancing patency of said prosthetic implant.