Patent ID: 8513264
Filing Date: 2013-08-20
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising: (a) a GPR119 agonist of formula (10)  (10), wherein one of X and Y is O and the other is N, R formula (11)  (11), wherein one of X and Y is O and the other is N, R formula (12)  (12), wherein one of X and Y is O and the other is N, R formula (13)  (13), wherein one of X and Y is O and the other is N, one of E and Q is N and the other is CH, R formula (14)  (14), wherein one of X and Y is O and the other is N, R formula (15)  (15), 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, or a pharmaceutically acceptable salt thereof; and (b) a DPP-4 inhibitor of wherein: R1 is ([1,5]naphthyridin-2-yl)methyl, (quinazolin-2-yl)methyl, (quinoxalin-6-yl)methyl, (4-methyl-quinazolin-2-yl)methyl, 2-cyano-benzyl, (3-cyano-quinolin-2-yl)methyl, (3-cyano-pyridin-2-yl)methyl, (4-methyl-pyrimidin-2-yl)methyl, or (4,6-dimethyl-pyrimidin-2-yl)methyl; and R2 is 3-(R)-amino-piperidin-1-yl, (2-amino-2-methyl-propyl)-methylamino, or (2-(S)-amino-propyl)-methylamino, or a pharmaceutically acceptable salt thereof.