Patent ID: 6740662
Filing Date: 2004-05-25
Classification: A61K,A61P,C07D

Abstract:
A naphthynidine derivative represented by the following formula (Iâ€²) or a pharmaceutically acceptable salt thereof (wherein each symbol has the following meaning;R1: â€”R0, -a lower alkylene-cycloalkyl or -a cycloalkyl R0: -a lower alkyl, R2, R3, and R4: â€”H, â€”R0, -a halogen, -a lower alkylene-OH, -a lower alkylene-SH, -a lower-alkylene-Oâ€”R0, -a lower alkylene-Sâ€”R0, -a lower alkylene-Oâ€”COâ€”R0, -a lower alkylene-Sâ€”COâ€”R0, â€”OH, â€”Oâ€”R0, â€”Sâ€”R0, â€”SOâ€”R0, â€”SO2â€”R0, â€”NH2, â€”NHR0, â€”NR02, -a cycloalkyl, â€”COâ€”R0, or â€”CH&boxH;Nâ€”OR9, which may be the same or different from one another, R9: â€”H, â€”R0 or -a lower alkylene-aryl, R5: a cycloalkyl which may be substituted with a group selected from R10, a cycloalkenyl which may be substituted with a group selected from R10, or phenyl which may be substituted with a group selected from R10, R6: â€”OH, â€”OR7, â€”COOH, â€”COOR7, â€”CONH2, â€”CONHR7, â€”CON(R7)2, â€”Oâ€”COR7, â€”Oâ€”COOR7, â€”CHO, â€”COR7, â€”NH2, â€”NHR7, â€”N(R7)2, â€”NHCOR7, â€”N(R7)COR7, â€”NHSO2R7, â€”N(R7)SO2R7, â€”CN, â€”NHCOOR7, â€”N(R7)COOR7, â€”C(NH)NH2, â€”NHC(NH)NH2 or â€”N(R7)C(NH)NH2, or a group represented by the formula â€”Yâ€”R8, R7: a lower alkyl which may be substituted with a group selected from the group consisting of â€”OH, -phenyl, -a halogen, â€”OR0, â€”CO2H, â€”CO2R0, â€”NH2, â€”NHR0, â€”NR02, â€”NO2, â€”CN, and â€”COR0, R8: a cycloalkyl which may be substituted with a group selected from R10, an aryl which may be substituted with a group selected from R10, or a heterocyclic group which may be substituted with a group selected from R10, R10: â€”OH, -phenyl, -a halogen, â€”OR0, â€”CO2H, â€”CO2R0, â€”NH2, â€”NHR0, â€”NRO2, â€”NO2, â€”CN or â€”COR0, or a group described in R7. Y: a bond, â€”Oâ€”, â€”COOâ€”, â€”CONHâ€”, â€”CON(R7)â€”, â€”Oâ€”COâ€”, â€”Oâ€”COOâ€”, â€”COâ€”, â€”NHâ€”, â€”N(R7)â€”, â€”NHCOâ€”, â€”N(R7)COâ€”, â€”NHCOOâ€”, â€”N(R7)COOâ€”, â€”NHSO2â€”, or â€”N(R7)SO2â€”, and X: a bond, a lower alkylene, or a lower alkenylene, provided that, when X is a bond, then R6 is â€”Yâ€”R8 and Y is a bond).