Patent ID: 7741519
Filing Date: 2010-06-22
Classification: A61K,A61P,C07D

Abstract:
1. A modulator of the formula (I) or a salt or N-oxide thereof: L is —C(O)—, —S—, —S(O)— or —S(O) X represents from 1 to 5 substituents independently selected from the group consisting of halogen, substituted or unsubstituted C Y represents from 1 to 4 substituents, each independently selected from the group consisting of halogen, —CN, —NO Z represents from 0 to 5 substituents independently selected from the group consisting of halogen, unsubstituted or substituted C N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-4-nitro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-iodo-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-chloro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-tert-butyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-propyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-ethyl-benzenesulfonamide N-(2-Benzoyl-4-nitro-phenyl)-4-ethyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-isopropyl-benzenesulfonamide N-(2-Benzoyl-4-bromo-phenyl)-4-ethyl-benzenesulfonamide N-(2-Benzoyl-4-bromo-phenyl)-4-methoxy-benzenesulfonamide N-(2-Benzoyl-4-bromo-phenyl)-4-isopropyl-benzenesulfonamide 4-Ethyl—N-[4-nitro-2-(3-trifluoromethyl-benzoyl)-phenyl]-benzenesulfonamide N-[4-Chloro-2-(3-methyl-benzoyl)-phenyl]-4-ethyl-benzenesulfonamide N-(2-Benzoyl-4-bromo-phenyl)-4-chloro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-ethoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-propoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-butoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-benzyloxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-phenoxy-benzenesulfonamide N-(2-Benzoyl-4-nitro-phenyl)-4-chloro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-2-nitro-benzenesulfonamide N-(2-Benzoyl-4-nitro-phenyl)-4-isopropyl-benzenesulfonamide N-(2-Benzoyl-4-nitro-phenyl)-4-isopropoxy-benzenesulfonamide N-(2-Benzoyl-4-nitro-phenyl)-4-methoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-trifluoromethoxy-benzenesulfonamide N-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-methoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-methoxy-benzenesulfonamide N-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-ethyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-ethylamino-benzenesulfonamide N-(2-Benzoyl-4-iodo-phenyl)-4-isopropoxy-benzenesulfonamide N-[4-Chloro-2-(3-fluoro-benzoyl)-phenyl]-4-methyl-benzenesulfonamide N-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-isopropyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-nitro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-diethylamino-benzenesulfonamide N-(2-Benzoyl-4-fluoro-phenyl)-4-methoxy-benzenesulfonamide N-(2-Benzoyl-4-bromo-phenyl)-4-methyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-bromo-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-dimethylamino-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-fluoro-benzenesulfonamide 4-Chloro—N-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-benzenesulfonamide N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-methoxy-benzenesulfonamide N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-nitro-benzenesulfonamide N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-methyl-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-benzenesulfonamide N-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]-acetamide N-(2-Benzoyl-4-chloro-phenyl)-4-cyano-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-3-bromo-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-methyl-3-nitro-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-2-trifluoromethyl-benzenesulfonamide N-(2-Benzoyl-phenyl)-4-nitro-benzenesulfonamide N-(2-Benzoyl-phenyl)-4-methyl-benzenesulfonamide N-(2-Benzoyl-4-trifluoromethyl-phenyl)-4-isopropoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-isopropylamino-benzenesulfonamide 6-Isopropoxy-pyridine-3-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide; N-(2-Benzoyl-phenyl)-4-isopropoxy-benzenesulfonamide; N-(2-benzoyl-4-methylphenyl)-4-chloro-benzenesulfonamide; N-(2-benzoylphenyl)-3,5-bis(trifluoromethyl)-benzenesulfonamide; N-(4-amino-2-benzoylphenyl)-4-methoxy-benzenesulfonamide; N-[4-[[(2-benzoyl-4-chlorophenyl)amino]sulfonyl]phenyl]-acetamide; N-(2-benzoyl-4-chlorophenyl)-4-ethyl-benzenesulfonamide; N-(2-benzoylphenyl)-4-chloro-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-2,5-dichloro-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-2,4,6-trimethyl-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-2,4,6-tris(1-methylethyl)-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-4-methoxy-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-4-tricyclo[3.3.1.13,7]dec-1-yl-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-2,4-dichloro-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-4-bromo-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-4-chloro-benzenesulfonamide; N-(2-benzoyl-4-chlorophenyl)-4-fluoro-benzenesulfonamide; N-[4-bromo-2-(2-fluorobenzoyl)phenyl]-3,4-dimethoxy-benzenesulfonamide; N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-4-(2-propenyloxy)-benzenesulfonamide; N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3,4-dimethoxy-benzenesulfonamide; N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2,5-dimethoxy-benzenesulfonamide; 2-amino—N-(2-benzoyl-4-methylphenyl)-benzenesulfonamide; N-(2-benzoyl-5-methylphenyl)-N,4-dimethyl-benzenesulfonamide; 2-amino-2′-benzoyl-4′-chloro-benzenesulfonanilide; and 2-benzoyl-4,4′-dichloro-2-nitro-benzenesulfonamide.