Patent ID: 6372920
Filing Date: 2002-04-16
Classification: C07D

Abstract:
A process for preparing an optically active or a racemic compound of the following general formula: wherein R1 is OA; R2 is selected from the group consisting of H and OA; wherein A is H or is selected from, the group consisting of a straight or a branched alkyl chain having from 1 to 3 carbon atoms, wherein R5 is selected from the group consisting of C1-C20 alkyl, C6-C10 aryl and C7-C20arylalkyl; R3 is selected from the group consisting of alkoxy, cycloalkoxy, optionally substituted phenyl, 3-pyridyl, 4-pyridyl, wherein X is O, S or NH; R4 is an unbranched alkyl chain having from 1 to 3 carbon atoms; and n is an integer from 1 to 5, wherein the process comprises allowing a 2-aminotetralin of the formula: to react with a reactant of the formula:Zâ€”(CH2)nâ€”R3 wherein R3 and n are as defined above, and Z is a leaving group, in the presence of a base, wherein the base is selected from the group consisting of alkali metal carbonate and alkali metal bicarbonate, and wherein the amount of the base is less than about a 1.9-fold molar excess with respect to the amount the 2-aminotetralin.