Patent ID: 6103761
Filing Date: 2000-08-15
Classification: C07C,C07D

Abstract:
A compound of formula ##STR94## or a pharmaceutically acceptable salt thereof wherein: Z and Z' are each independently selected from:hydrogen,CN,alkyl of from 1 to 6 carbon atoms,branched alkyl of from 3 to 9 carbon atoms,cycloalkyl or polycycloalkyl of from 5 to 12 carbon atoms unsubstituted, mono- or disubstituted with one 6r more substituents selected from:alkyl,branched allyl,CO.sub.2 R.sup.1, and--OR.sup.3 wherein R.sup.1 is as defined below, andR.sup.3 ishydrogen,--CH.sub.3,--CH.sub.2 CH.sub.3, orC(O)CH.sub.3 ;unsubstituted, mono- or polysubstituted phenyl, polyaromatic, heteroaromatic, or hydroaromatic which substituents are selected from:alkyl of from 1 to 6 carbon atoms,branched allyl of from 3 to 9 carbon atoms,hydrogen,--CN,--F,--Cl,--Br,--I,--NO.sub.2,--CF.sub.3,--SMe,--S(O).sub.2 CF.sub.3,--S(O)Me,--S(O).sub.2 Me,--(CH.sub.2).sub.m S(O).sub.2 OR.sup.1,--S(O).sub.2 NR.sup.1 R.sup.2,--CHO,--C(NOH)H,--(CH.sub.2).sub.m CO.sub.2 R.sup.1,--C(O)NR.sup.1 R.sup.2,--NR.sup.1 R.sup.2,--C(O)CO.sub.2 R.sup.1,--C(NOH)CO.sub.2 R.sup.1,--OR.sup.1,--OAc, ##STR95## A' is ##STR96## A' is a bond, ##STR97## Q and Q' are each independently NY, NY' wherein Y and Y' are each independently:hydrogen,phenyl,benzyl,straight alkyl of from 1 to 4 carbon atoms,branched alkyl of 3 or 4 carbon atoms,--(CH.sub.2).sub.n CO.sub.2 R.sup.1, or--(CH.sub.2).sub.n --C(O)NR.sup.1 R.sup.2 ;W and W' are each independently:phenyl which is unsubstituted, mono- or polysubstituted by:hydrogen,--CN,--SMe,--SO.sub.2 CF.sub.3,--S(O)Me,--S(O).sub.2 Me,--(CH.sub.2).sub.m S(O).sub.2 OR.sup.1,--S(O).sub.2 NR.sup.1 R.sup.2,--CHO,--C(NOH)H,--(CH.sub.2).sub.m CO.sub.2 R.sup.1,--C(O)NR.sup.1 R.sup.2,--NR.sup.1 R.sup.2,--(CO)CO.sub.2 R.sup.1,--C(NOH)CO.sub.2 R.sup.1,--OR.sup.1,--OAc,--F,--Br,--Cl,--I,--CF.sub.3,--NO.sub.2,alkyl of from 1 to 6 carbon atoms,branched alkyl of from 3 to 9 carbon atoms, ##STR98## also, W and W' are each independently: ##STR99## cyclo or polycycloalkyl unsubstituted or substituted by one or more selected from alkyl, CO.sub.2 R.sup.1, and --S(O).sub.2 OR.sup.1,M and M' are each independently hydrogen, methyl, or fluorine,R.sup.1 and R.sup.2 are each independently hydrogen or lower alkyl;with the proviso that at least one urea or sulfonylurea is present and at least one heterocycle is present.