Patent ID: 8759004
Filing Date: 2014-06-24
Classification: A61K,A61P,C12N,C12Q,G01N

Abstract:
1. A method for detection of carcinomas or their precursor lesions comprising: a) obtaining a biological test sample from a human; b) binding in the test sample an antibody that specifically binds to peptide sequence SEQ ID NO: 3 of human DNase-X polypeptide or an antigen binding fragment thereof to determine the level of peptide comprising sequence SEQ ID NO: 3 in the test sample; c) comparing the level of peptide comprising sequence SEQ ID NO: 3 of human DNase-X polypeptide within said test sample to the level of peptide comprising sequence SEQ ID NO: 3 of human DNase-X polypeptide within a corresponding control sample; and d) classifying a test sample exhibiting an increased level of peptide comprising sequence SEQ ID NO: 3 of human DNase-X polypeptide relative to the level of peptide comprising sequence SEQ ID NO: 3 of human DNase-X polypeptide in the control sample as indicative of the presence of a carcinoma or precursor lesion, wherein the carcinoma is a colon, breast, lung, cervical, gastric, esophageal, endometrial, ovarian, or bladder carcinoma, and wherein the precursor lesion is a precursor lesion for colon carcinoma or breast carcinoma.