Patent ID: 7989606
Filing Date: 2011-08-02
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule that encodes a variant phosphatase inhibitor-1 protein, wherein the nucleic acid molecule encodes a polypeptide having at least 90% identity to: (a) SEQ ID NO:6 or a fragment of SEQ ID NO: 6; (b) SEQ ID NO: 21 or a fragment of SEQ ID NO: 21; or (c) SEQ ID NO:16 or a fragment of SEQ ID NO: 16, and wherein the polypeptide or the fragment comprises: (i) a constitutively phosphorylated amino acid at position 35, said constitutively phosphorylated amino acid being aspartic acid or glutamic acid and (ii) a constitutively unphosphorylated amino acid at positions 67 and/or 75, wherein the polypeptide or fragment inhibits the activity of a protein phosphatase I as determined by an assay using a rabbit protein phosphatase I.