Patent ID: 8357704
Filing Date: 2013-01-22
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 2-Methoxy-N-(5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(2-methyl-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(5-phenyl-4,5,6,7-tetrahydro-benzo[d]isoxazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(5-phenyl-4,5,6,7-tetrahydro-benzo[c]isoxazol-5-ylmethyl)-benzamide; N-(1,5-Diphenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)-2-methoxy-benzamide; N-(2,5-Diphenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-2-methoxy-benzamide; N-[1-(2-Hydroxy-ethyl)-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[2-(2-Hydroxy-ethyl)-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[1-(6-Chloro-pyridazin-3-yl)-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[2-(6-Chloro-pyridazin-3-yl)-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-(2-tert-Butyl-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-2-methoxy-benzamide; N-(1-Benzyl-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)-2-methoxy-benzamide; N-(2-Benzyl-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-2-methoxy-benzamide; 2-Methoxy-N-[5-phenyl-2-(propane-2-sulfonyl)-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-benzamide; 2-Methoxy-N-[5-phenyl-1-(propane-2-sulfonyl)-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-benzamide; N-(2-Methanesulfonyl-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-2-methoxy-benzamide; 2-Methoxy-N-[1-(1-methyl-1H-imidazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-benzamide; 2-Methoxy-N-[2-(1-methyl-1H-imidazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-benzamide; 2-Methoxy-N-[5-phenyl-2-(2,3,4-trifluoro-benzenesulfonyl)-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-benzamide; 2-Methoxy-N-[5-phenyl-1-(2,3,4-trifluoro-benzenesulfonyl)-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-benzamide; N-[2-(5-Chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[1-(5-Chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[2-(3,5-Dimethyl-isoxazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl]-2-methoxy-benzamide; N-[1-(3,5-Dimethyl-isoxazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl]-2-methoxy-benzamide; 2-Methoxy-N-(5-phenyl-4,5,6,7-tetrahydro-1H-benzoimidazol-5-ylmethyl)-benzamide; N-[1-(3,5-Dimethyl-isoxazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-1H-benzoimidazol-5-ylmethyl]-2-methoxy-benzamide; N-[3-(3,5-Dimethyl-isoxazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-3H-benzoimidazol-5-ylmethyl]-2-methoxy-benzamide; N-[3-(5-Chloro-3-methyl-1H-pyrazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-3H-benzoimidazol-5-ylmethyl]-2-ethoxy-benzamide; N-[1-(5-Chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-5-phenyl-4,5,6,7-tetrahydro-1H-benzoimidazol-5-ylmethyl]-2-methoxy-benzamide; N-(2-Amino-6-phenyl-4,5,6,7-tetrahydro-benzothiazol-6-ylmethyl)-2-methoxy-benzamide; N-(2-Acetylamino-6-phenyl-4,5,6,7-tetrahydro-benzothiazol-6-ylmethyl)-2-methoxy-benzamide; N-(2-Diacetylamino-6-phenyl-4,5,6,7-tetrahydro-benzothiazol-6-ylmethyl)-2-methoxy-benzamide; 2-Methoxy-N-(3-methyl-5-phenyl-4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(3-methyl-5-phenyl-4,5,6,7-tetrahydro-benzo[d]isoxazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(3-methyl-5-phenyl-4,5,6,7-tetrahydro-benzo[c]isoxazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(3-oxo-5-phenyl-2,3,4,5,6,7-hexahydro-1H-indazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(3-oxo-5-phenyl-1,3,4,5,6,7-hexahydro-benzo[c]isoxazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(1-methyl-3-oxo-5-phenyl-1,3,4,5,6,7-hexahydro-benzo[c]isoxazol-5-ylmethyl)-benzamide; 2-Methoxy-N-(6-phenyl-4,5,6,7-tetrahydro-benzo[1,2,3]thiadiazol-6-ylmethyl)-benzamide; 2-Methoxy-N-(6-phenyl-4,5,6,7-tetrahydro-1H-indazol-6-ylmethyl)-benzamide; 2-Methoxy-N-(2-methyl-6-phenyl-4,5,6,7-tetrahydro-2H-indazol-6-ylmethyl)-benzamide; 2-Methoxy-N-(6-phenyl-4,5,6,7-tetrahydro-benzo[d]isoxazol-6-ylmethyl)-benzamide; 2-Methoxy-N-(6-phenyl-4,5,6,7-tetrahydro-benzo[c]isoxazol-6-ylmethyl)-benzamide; 2-Methoxy-N-(3-phenyl-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-benzamide; 2-Methoxy-N-(9-methyl-3-phenyl-2,3,4,9-tetrahydro-1H-carbazol-3-ylmethyl)-benzamide; 2-Methoxy-N-(((6S,7aS)-3-methoxy-6-phenyl-3 a,4,5,6,7,7a-hexahydrobenzo[d]isoxazol-6-yl)methyl)benzamide; 2-Methoxy-N-(((3 aS,5 S)-3-methoxy-5-phenyl-3a,4,5,6,7,7a-hexahydrobenzo[d] isoxazol-5-yl)methyl)benzamide; 2-Methoxy-N-(((3 aS,5R)-3-methoxy-5-phenyl-3 a,4,5,6,7,7a-hexahydrobenzo[d]isoxazol-5-yl)methyl)benzamide; and 2-Methoxy-N-(((6R,7aS)-3-methoxy-6-phenyl-3 a,4,5,6,7,7a-hexahydrobenzo[d] isoxazol-6-yl)methyl)benzamide.