Patent ID: 8626452
Filing Date: 2014-01-07
Classification: A61K,G01N,Y02A

Abstract:
1. A process for optimizing a therapeutic drug to reduce or prevent export of the therapeutic drug from a cell by an exporter protein, the method comprising the steps of: a) measuring hydrophobicity of the therapeutic drug by measuring ΔG b) generating a modified therapeutic drug by modifying the therapeutic drug to increase the hydrophobicity of the therapeutic drug; c) measuring hydrophobicity of the modified therapeutic drug by measuring ΔG d) determining a change in rate of export from the cell of the modified therapeutic drug compared to the therapeutic drug; wherein the modified therapeutic drug becomes an optimized therapeutic drug when the modified therapeutic drug upon administration to the cell decreases or prevents disruption of hydrophobic associations required for opening of a transit pathway within the exporter protein in the cell.