Patent ID: 6630457
Filing Date: 2003-10-07
Classification: A61K,A61L,C08B,C08L,C12N

Abstract:
A composition comprising crosslinked derivatives of hyaluronic acid comprising disaccharide subunits, wherein at least one of said disaccharide subunits is a substituted disaccharide subunit having a substitution at a carboxyl group, such that the substituted disaccharide subunit is of the formula wherein each of Râ€² and Râ€³ is a side chain comprising one or more functional groups selected from the group consisting of hydrogen; bioactive peptide; alkyl; aryl; alkylaryl; arylalkyl; substituted alkylaryl containing an atom or atoms of oxygen, nitrogen, sulfur, or phosphorous; substituted arylalkyl containing an atom or atoms of oxygen, nitrogen, sulfur; phosphorous, halogen, or metal ion; and substituted heterocycle containing an atom or atoms of oxygen, nitrogen, sulfur; phosphorous, halogen or metal ion; wherein said functional groups within or among each of said Râ€² or Râ€³ side chains are either bound directly to each other or are separated by a member selected from the group consisting of ether, keto, amino, oxycarbonyl, sulfone, sulfoxide, carboxamide, alkyne and alkene; and wherein each of said Râ€² and Râ€³ side chains terminates with a terminal functional group selected from the group consisting of hydrogen, peptide, aldehyde, amine, arylazide, hydrazide, maleimide, sulfhydryl, active ester, ester, carboxylate, imidoester, halogen and hydroxyl; or wherein said terminal functional groups of each of said Râ€² and Râ€³ side chains may be bound directly to each other, with the proviso that when one of Râ€² or Râ€³ is hydrogen, halogen or univalent metal ion, then Râ€² and Râ€³ may not be bound directly to each other; wherein said derivatives of hyaluronic acid are covalently crosslinked via one of said terminal functional groups; and wherein said derivatives of hyaluronic acid are modified to an extent of 10-95%.