Patent ID: 6815423
Filing Date: 2004-11-09
Classification: C07K,G01N

Abstract:
A compound of the formula: wherein R1 is a light-emitting moiety and R2 is a substance P-based peptide, fragment, derivative or analog thereof, wherein R2 is comprised of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met (SEQ ID NO: 1), said peptide being linked at an amino acid position to (Câ€”X), wherein (Câ€”X) is selected from the group consisting of C&boxH;O, C&boxH;S, CH(OH), C&boxH;C&boxH;O, C&boxH;NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties, wherein said compound exhibits substantial biological activity in the presence of a receptor having affinity for substance P-based peptides.