Patent ID: 8952207
Filing Date: 2015-02-10
Classification: C07B,C07C,C07D

Abstract:
1. A method for the direct conversion of C—H bonds to carbon-carbon bonds comprising the step of contacting a substrate including an acidic sp 2 C—H bond and an aryl halide in the presence of a catalyst comprising a copper(I) salt and a base in the absence of a palladium, rhodium, or ruthenium salt, where the catalyst is capable of deprotonating the hydrogen atom of the acidic sp 2 C—H bond, where the substrate comprises an electron-rich heterocyclic substrate having an acidic sp 2 C—H bond or a plurality of electron-rich heterocyclic substrates having an acidic sp 2 C—H bond, and where the carbon-carbon bonds form between the sp 2 carbon atoms of the acidic sp 2 C—H bonds and a carbon atom of the aryl halide.