Patent ID: 7097825
Filing Date: 2006-08-29
Classification: A61P,G01R,Y10T

Abstract:
1. A method for measuring a blood oxygen level-dependent magnetic resonance imaging signal, compnsing a) administering an effective amount of an allosteric effector compound capable of decreasing hemoglobin binding affinity for oxygen; and b) performing a blood oxygen level-dependent magnetic resonance imaging scan, whereby said blood oxygen level-dependent magnetic resonance imaging signal is measured, wherein the allosteric effector compound is a compound selected from the group consisting of: a compound having the formula: where R R R a compound having the formula: where X and Z may each be CH R R R a compound having the formula: where R R sites R R a compound having the formula: where R sites R R X is a carboxyl, Y is a nitrogen, and R where X, Y, and Z, may either be CH a compound having the formula: where R R where the R a compound having the formula: where R X is a carbonyl, Y is a nitrogen, and R where R R R a compound having the formula: where A is a chemical bridge which includes two to four chemical moieties bonded together, the chemical moieties in A are selected from the group consisting of CO, O, S, SO at least one of R where n is zero to five, where R a compound having the formula: where R where R where A is a chemical bridge which includes three chemical moieties bonded together between R wherein the chemical moieties in A are selected from the group consisting of CO, O, S, SO where at least one of R where n is zero to five, where R where R a compound having the formula: where R where R where A is a chemical bridge which includes two to four chemical moieties bonded together between R wherein said chemical moieties in A are selected from the group consisting of CO, O, S, SO wherein at least one of R where n is zero to five, where R where R a compound having the formula: where R