Patent ID: 6369098
Filing Date: 2002-04-09
Classification: A61K,C07D

Abstract:
A compound having the formula wherein:R is a member selected from the group consisting of R or S or racemic 1,2-dithiolan-3-yl, or achiral 1,2-dithiolan-4-yl, R or S or racemic 1-(1,3-dithiopropanyl), R or S or racemic S,Sâ€²-diacyl-[1-(1,3-dithiopropanyl)], R or S or racemic or achiral 2-(1,3-dithiopropanyl), R or S or racemic or achiral S,Sâ€²-diacyl-[2-(1,3-dithiopropanyl)]; and optionally substituted 3R or 3S or racemic 3H-benzo[d]1,2-dithiolen-6-yl; R1 is a member selected from the group consisting of hydrogen, alkyl, arylalkyl and aryl; R11 is a member selected from the group consisting of R, S or racemicâ€”CH2(Z)CHCO2R12, â€”CH2CO2R12, â€”CO2R12, wherein R12 is a member selected from the group consisting of hydrogen, alkyl, arylalkyl and aryl; A is oxygen or, together with the carbon to which it is bound is a methylene group; B is a member selected from the group consisting of N, O and S, provided that when B is 0 or S then R1 is absent; X is a member selected from the group consisting of hydrogen, halogen, OR3, NH2, NHR3, NR3R10, SR3, SOR3, SONH2, SONHR3, SO2NH2, SO2R3, SO2NHR3 and SO3R3 wherein R3 and R10 are each independently a member selected form the group consisting of hydrogen, alkyl, arylalkyl and aryl; Y is a member selected from the group consisting of oxygen, S, SO, SO2, SO2NH, SO2NR12, SO3, NH, NR12, wherein R12 is a member selected form the group consisting of hydrogen, alkyl, arylalkyl and aryl; Z is a member selected from the group consisting of R S-phenyl, S S-phenyl, racemic S-phenyl, SCH3, SCH2CH3, Oâ€”phenyl, OCH3, SCH2CH3, propyl, butyl, pentyl, hexyl, benzyl, haloalkyl, NHR13, NR13R14, wherein R13 and R14 are each independently a member selected from the group consisting of â€”(CO)alkyl, optionally substituted â€”(CO)aryl, optionally substituted â€”(CO)arylalkyl, optionally substituted â€”(CO)heteroaryl and â€”CHO; m is an integer from 1 to 8 inclusive; r is 0 or 1; n is 0, 2, 3, 4; and p is 0 or 1, with the proviso that when n is 0 then Y is not O, S, N, resulting in N-O, N-S, and N-N bonds.