Patent ID: 8969547
Filing Date: 2015-03-03
Classification: C07J

Abstract:
1. A method for preparing fluticasone furoate, comprising reacting Compound II (6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-hydroxy-3-oxo-androsta-1,4-diene-17β-carbothioic acid) and triethylamine in a first solvent to obtain an amine salt, reacting the amine salt with furoyl chloride to obtain Compound III (6α,9α-difluoro-17-carboxylic furan-2-carboxylic thioanhydride-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17α-yl furoate), reacting a fluoromethylating reagent and an organic base in a second solvent to form a complex, and adding the Compound III to the complex to have a replacement reaction between a fluoromethyl group of the complex and a furoyl group of the Compound III to obtain Compound I (6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester).