Patent ID: 8722332
Filing Date: 2014-05-13
Classification: A61K,A61P,C07K,C12Q

Abstract:
1. A kit for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, the kit comprising: a probe capable of determining the genotype of the Dirofilaria spp. nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 11 of SEQ ID NO: 1 or a nucleotide sequence at least 80% identical to SEQ ID NO: 1; or a probe capable of determining the genotype of the Dirofilaria spp. nematode at positions in a P-glycoprotein gene of the nematode corresponding to positions 11 and 618 of SEQ ID NO: 1; wherein said probe comprises a label and wherein the genotype GG at said position corresponding to position 11 in SEQ ID NO: 1 or the genotype GG at said positions corresponding to positions 11 and 618 in SEQ ID NO: 1, indicates that the nematode is likely to be resistant to said macrocyclic lactone.