Patent ID: 6696425
Filing Date: 2004-02-24
Classification: A61K,Y10S

Abstract:
A method of stimulating tear secretion and mucin production in eyes of a subject comprising the step of administering to the eyes of the subject an effective amount of a composition comprising a compound of Formula II or a pharmaceutically acceptable salt thereof: wherein:X is oxygen, imido, methylene or difluoromethylene; X is oxygen, imido, methylene or difluoromethylene; Y is H or OH; Yâ€² is H or OH; n=0, 1, or 2; m=0, 1, or 2; n+m=0-4; and B and Bâ€² are each independently a purine residue, as in Formula IIa, linked through the 9-position: wherein:Rx is O, H or is absent; Ry is hydrogen, chlorine, amino, monosubstituted amino, disubstituted amino, alkylthio, arylthio, or aralkylthio, wherein the alkylthio, arylthio, or aralkylthio group contains up to a maximum of 20 carbon atoms, with or without unsaturation; Rz is oxo, mercapto, thione, alkylthio, arylthio, aralkylthio, acylthio, alkyloxy, aryloxy, aralkyloxy, acyloxy, amino, mono-substituted amino or di-substituted amino; R3 is hydrogen, azido, alkoxy, aryloxy, aralkyloxy, alkylthio, arylthio, aralkylthio, amino, mono-substituted amino, di-substituted amino, or T(C1-6alkyl)OCONH(C1-6alkyl)W wherein T and W are independently amino, mercapto, hydroxy or carboxyl, or pharmaceutically acceptable esters, amides or salts thereof.