Patent ID: 6458812
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound having the structural formula: or a pharmaceutically acceptable salt, ester or solvate thereof, whereinR1 is R5â€”(C3-C8)cycloalkyl, R5â€”(C3-C8)cycloalkyl(C1-C6)alkyl, R5-aryl, or R5-aryl-(C1-C6)alkyl; R2 is H, (C1-C6)alkyl, R6â€”(C3-C8)cycloalkyl, R6â€”(C3-C8)cycloalkyl-(C1-C6)alkyl, or R6â€”(C6-C10)bridged cycloalkyl; R3 is C1-C6 alkyl or â€”CH2OH; R4 is H or C1-C6 alkyl; R5 is 1-4 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, C1-C6 alkoxy, CF3, â€”CN, â€”CO2R4, â€”CONHR4,â€”SO2NHR4, â€”NHSO2R4 and â€”NHC(O)R4; and R6 is 1-4 substituents independently selected from the group consisting of H, C1-C6 alkyl, halogen, â€”OH, C1-C6 alkoxy, CF3, â€”NH2, (C1-C6)alkylamino, phenyl, C1-C2 alkylenedioxy, and (C1-C6)alkoxycarbonyl.