Patent ID: 7939074
Filing Date: 2011-05-10
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating an Ep-CAM expressing tumor in a subject comprising administering an anti-Ep-CAM antibody and a chemotherapeutic agent that is capable of arresting Ep-CAM antigen expressing cells in S or G 2 /M to a subject with an Ep-CAM expressing tumor, wherein the chemotherapeutic agent is selected from the group consisting of camptothecin-11, oxaliplatin, paclitaxel, docetaxel, cyclophosphamide, vinorelbine tartrate, epirubicin, mitoxantrone, raltitrexed, carboplatinum, etoposide and topotecan, and is administered to the subject prior to, or simultaneously with, the anti-Ep-CAM antibody; whereby the Ep-CAM expressing tumor in the subject is treated.