Patent ID: 6706753
Filing Date: 2004-03-16
Classification: A61P,C07C,C07D

Abstract:
A compound having the general formula (II): whereinis alkyl, alkenyl or alkynyl optionally substituted with halogen, carboxyl, alkyl or aryl, and wherein one or more carbon atoms are optionally replaced with O, N, NR6, S, SO, or SO2; R1 is hydrogen or is selected form the group consisting of alkyl, alkenyl and alkynyl, each of which is optionally substituted with hydroxyl, halogen, amino, nitro, carboxyl, a carbocycle, or a heterocycle; or R1, is a carbocycle or heterocycle optionally substituted with hydroxyl, oxo, halogen, amino, or nitro; R3 and R4 are independently selected from the group consisting of H, hydroxyl, halogen, amino, nitro, carboxyl, alkyl, alkenyl, alkynyl, a carbocycle and a heterocycle, wherein said alkyl, alkenyl, alkynyl, carbocycle and heterocycle groups are optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, amino, oxo and carboxyl, and optionally one or more carbon atoms of said alkyl, alkenyl and alkynyl group is replaced with N, NR6, S, SO or SO2; R6 is hydrogen, alkyl, alkenyl or alkynyl; R7 is hydrogen, hydroxyl, halogen, alkyl, alkoxy or halogen substituted alkyl; R8 is H, alkyl, alkenyl or alkynyl; R9 is NR11R11â€² wherein one of R11 and R11â€² is H, acyl or an amino acid residue; and the other together with R9 forms a heterocycle: R10 is O or S; m and n are independently 1, 2 or 3; p is an integer from 1 to 5; and salts, solvates and hydrates thereof.