Patent ID: 7960506
Filing Date: 2011-06-14
Classification: A61K,A61P,C07K

Abstract:
1. A peptidomimetic macrocycle of Formula (I): wherein: each A, C, D, and E is independently a natural or non-natural amino acid; B is a natural or non-natural amino acid, an amino acid comprising one or more additional methylene groups between the amino and carboxyl group, an amino acid comprising an amino group which is a secondary or tertiary amine, an amino acid comprising a carboxy group replaced by an ester,  [—NH-L R R L K is O, S, SO, SO each R each R each R R R v is an integer from 1-1000; w is an integer from 1-1000; x is an integer from 0-10; y is an integer from 0-10; z is an integer from 0-10; n is an integer from 1-5; x+y+z is at least 3; and wherein the peptidomimetic macrocycle comprises an alpha-helix, wherein a secondary structure of the peptidomimetic macrocycle is more stable than a corresponding secondary structure of a corresponding non-macrocyclic polypeptide, and wherein the non-macrocyclic polypeptide lacks [-L