Patent ID: 8628790
Filing Date: 2014-01-14
Classification: A61F,A61K,A61L,A61P

Abstract:
1. A therapeutic coating that promotes formation of a functional endothelium on a medical device, the coating comprising: a biodegradable, drug-containing inner layer that is positioned over a surface of a medical device and serves as a source of a drug that functions as an anti-proliferative agent in a subject; and, a biodegradable, outer layer positioned over a surface of the inner layer and comprising a polymer adapted to render the coating non-eluting beginning at time of implantation in the subject and continuing thereafter for a time period of about 20 to about 40 days, the polymer being further adapted to block release of the drug from the coating into the subject during the aforesaid time period to form a functional endothelium over the surface of the medical device, the functional endothelium providing a source of thrombomodulin to the subject; wherein the polymer is still further adapted to allow the drug to elute from the coating after the aforesaid time period; wherein the polymer has ester-terminal groups, a molecular weight ranging from about 50 KDaltons to about 190 KDaltons, the structure comprising P—CO2R, where P is the polymer backbone and R is an alkyl group having from 1 to 4 carbons; whereby the coating promotes development of the functional endothelium as the source of the thrombomodulin when compared to a control development of such endothelium formation observed following implantation of a metal drug-eluting medical device; and the coating inhibits development of a hyperproliferative tissue when compared to a control development of such hyperproliferative tissue observed following implantation of a metal medical device.