Patent ID: 6114358
Filing Date: 2000-09-05
Classification: A61K,A61P,C07K

Abstract:
A compound of the formula I ##STR19## where A is ##STR20## where m is 0, 1 or 2,n is 0, 1 or 2,R.sup.1 is HOOC--, C.sub.1-6 -alkyl-OOC--, aryl-C.sub.1 -C.sub.4 -alkyl-OOC or --OH,R.sup.2 is H, C.sub.1-4 -alkyl or R.sup.1 -(CH.sub.2).sub.m -,R.sup.3 is H or C.sub.1-4 -alkyl,B is ##STR21## where R.sup.4 is H, C.sub.1-4 -alkyl or R.sup.1 -(CH.sub.2).sub.m - (where R.sup.1 and m have the abovementioned meanings),p is 0 or 1,R.sup.5 is H or C.sub.1-4 -alkyl,R.sup.6 is H, C.sub.1-8 -alkyl, phenyl which may carry up to three identical or different radicals from the group of C.sub.1-4 -alkyl, CF.sub.3, C.sub.1-4 -alkoxy, F or Cl, or C.sub.3-8 -cycloalkyl which may carry up to four identical or different C.sub.1-4 -alkyl radicals, or where one or two C--C single bonds in the ring can be replaced by a C.dbd.C double bond, or a phenyl ring can be fused on, C.sub.7 -C.sub.12 -bicycloalkyl or C.sub.10 -tricycloalkyl orR.sup.4 and R.sup.6 together are an ethylene or propylene group,R.sup.7 is H, C.sub.1-8 -alkyl, phenyl which may carry up to three identical or different radicals from the group of C.sub.1-4 -alkyl, CF.sub.3, C.sub.1-4 -alkoxy, F or Cl, or C.sub.3-8 -cycloalkyl which may carry up to four identical or different C.sub.1-4 -alkyl radicals,R.sup.8 is H or C.sub.1-4 -alkyl,E is ##STR22## q is 0 or 1 D is ##STR23## where R.sup.9 is H or C.sub.1-3 -alkyl,R.sup.10 is H or C.sub.1-4 -alkyl,R.sup.11 is H or C.sub.1-4 -alkyl,X is O, S, --NR.sup.12 (R.sup.12 .dbd.H, C.sub.1-6 -alkyl),Y is --N.dbd. or --CR.sup.13 .dbd. (R.sup.13 .dbd.H, C.sub.1-4 -alkyl), Cl, CF.sub.3,Z is --N.dbd. or --CR.sup.13 .dbd.,and the salts thereof with physiologically tolerated acids.