Patent ID: 6040328
Filing Date: 2000-03-21
Classification: A61P,C07C,C07D

Abstract:
Organoselenium compounds of general formula (I): ##STR31## in which: R=hydrogen; --CR.sub.1 R.sub.2)--A--B;R.sub.1 =lower alkyl; optionally substituted aryl; optionally substituted lower aralkyl;R.sub.2 =lower alkyl:optionally substituted aryl:optionally substituted lower aralkyl;A=CO; (CR.sub.3 R.sub.4)n;B represents NR.sub.5 R.sub.6 ; N.sup.+ R.sub.5 R.sub.6 R.sub.7 Y.sup.- ; OR.sub.5 ; SR.sub.5 ;Ar=an optionally substituted radical of formula: ##STR32## in which Z represents O; S; NR.sub.5 ; when R=--CR.sub.1 R.sub.2)--A--B orAr=a radical of formula ##STR33## in which Z=O; S; NR.sub.5 ; when R is hydrogen; X=Ar(R)--Se--; -S-glutathione ; --S--N-acetylcysteine; -S-cysteine-S-penicillamine; -S-albumin; -S-glucose; ##STR34## R.sub.3 =hydrogen; lower alkyl; optionally substituted aryl, optionally substituted lower aralkyl;R.sub.4 =hydrogen; lower alkyl; optionally substituted aryl:optionally substituted lower aralkyl;R.sub.5 =hydrogen; lower alkyl; optionally substituted aryl:optionally substituted lower aralkyl; optionally substituted heteroaryl; optionally substituted lower heteroaralkyl; CO(lower alkyl); CO(aryl); SO.sub.2 (lower alkyl); SO.sub.2 (aryl);R.sub.6 =hydrogen; lower alkyl; optionally substituted aryl; optionally substituted lower aralkyl; optionally substituted heteroaryl; optionally substituted lower heteroaralkyl;R.sub.7 =hydrogen; lower alkyl; optionally substituted aryl:optionally substituted lower aralkyl; optionally substituted heteroaryl; optionally substituted lower heteroaralkyl;R.sub.8 =hydrogen; lower alkyl; optionally substituted aryl; optionally substituted lower aralkyl; optionally substituted heteroaryl; optionally substituted lower heteroaralkyl; trifluoromethyl; ##STR35## n=0 or 1; X.sup.+ represents the cation of a pharmaceutically acceptable base;Y.sup.- represents the anion of a pharmaceutically acceptable acid; and their salts of pharmaceutically acceptable acids or bases.