Patent ID: 9180485
Filing Date: 2015-11-10
Classification: A61M,B05D

Abstract:
1. A method for preparing a substantially uniform coated balloon catheter and increasing adhesion of a coating layer on the coated balloon catheter, the method comprising: (1) preparing a coating solution consisting of a solvent, a therapeutic agent, and an additive, wherein: (2) loading a metering dispenser with the coating solution; (3) inflating the balloon catheter to 0 to 3 atm and rotating the balloon catheter about the longitudinal axis of the catheter and/or moving the balloon catheter in a linear direction along the longitudinal or transverse axis of the catheter; (4) dispensing the coating solution from the metering dispenser onto a surface of the balloon catheter and flowing the coating solution on the surface of the balloon catheter while the balloon catheter is rotating and/or linearly moving; (5) evaporating the solvent, forming a substantially uniform coating layer on the balloon catheter; (6) folding and wrapping the balloon catheter; (7) drying the balloon catheter after the solvent is evaporated and then sterilizing the balloon catheter with ethylene oxide; and (8) drying the sterilized balloon catheter under vacuum at about 0° C. to 100° C. for 2 hours to 56 hours, wherein adhesion of the substantially uniform coating layer to the balloon catheter is increased by the vacuum drying after the sterilization.