Patent ID: 8350008
Filing Date: 2013-01-08
Classification: A61P,C07K,C12Q

Abstract:
1. An isolated chimeric, human or humanized antibody, or an antigen-binding fragment thereof, specifically binding to a WISP-1 polypeptide selected from the group consisting of polypeptides comprising (1) amino acid residues 23 to 367 or 1 to 367 of (2) amino acid residues 23 to 367 or 1 to 367 of (3) amino acid residues 23 to 367 or 1 to 367 of (4) amino acid residues 23 to 367 or 1 to 367 of (5) the WISP-1 polypeptide encoded by the full-length coding sequence in ATCC Deposit No. 209533; (6) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 23; (7) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 24; (8) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 25; (9) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 26; (10) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID. NO: 27; (11) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 28; and (12) the WISP-1 polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 29, each with or without an N-terminal methionine, and a pharmaceutically acceptable carrier.