Patent ID: 8652505
Filing Date: 2014-02-18
Classification: A61F,B05D

Abstract:
1. A method for coating the surface of an implant comprising: (a) exposing the implant surface to a silane coupling agent, wherein said implant surface is a metallic material; (b) treating said implant surface with an aliphatic dialdehyde and bonding said dialdehyde to said silane coupling agent via imine functionality; (c) coating the implant surface with a first layer of polymeric material that is covalently bound to the implant surface, wherein said first polymeric material includes one or more of the following: chitosan, chitin or gelatin; (d) coating the first layer of polymeric material with a second layer of polymeric material wherein the second layer of polymeric material includes a drug for delivery and wherein said second layer of polymeric material is physically adhered to the first layer; (e) coating the second layer with a third outer layer; and (f) polymerizing said third outer layer, wherein said third outer layer is joined to the second layer in the form of an interpenetrating polymer network wherein said second and third layers become interlaced and said third outer layer penetrates into said second layer 1.0 μm to 5.0 μm prior to polymerization, wherein said third layer has higher mechanical strength than said first and second layers and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of administration of 0-95% and a sustained release of any remaining portion within a 14 day period.