Patent ID: 7355036
Filing Date: 2008-04-08
Classification: C07H,Y02P

Abstract:
1. A process for the synthesis of a nucleic acid by stepwise assembly of building blocks, wherein the building blocks are building blocks for the synthesis of a nucleic acid, wherein at least one of the building blocks carries a two-stage protective group, wherein the two-stage protective group contains a photoactivatable group selected from the group consisting of nitroveratryloxycarbonyl (NVOC), α-methyl-6-nitropiperonyloxycarbonyl (MeNPOC), 3,5 -dimethoxybenzoincarbonate (DMBOC), 2-(o-nitrophenyl)propyloxycarbonyl (NPPOC), o-nitrobenzyl and 2-(o-nitrophenyl) ethyl, wherein the photoactivable group is removed by an illumination step and the remainder of the two-stage protective group is removed by a subsequent acid treatment step.