Patent ID: 6346602
Filing Date: 2002-02-12
Classification: A61K,A61P,C07K

Abstract:
A peptide wherein said peptide mimics a loop on the &ggr;-chain that interacts with either a cytokine or a &ggr;-chain partner receptor chain of a heterodimeric cytokine receptor, consists of 5-25 amino acids, inhibits signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a &ggr;-chain, is conformationally restricted, and is selected from the group consisting of: SEQ ID NO:18 CIQLYQTFC; SEQ ID NO:19 CIHLYQTFC; SEQ ID NO:20 CLQYLVC; SEQ ID NO:21 CLEHLVC; SEQ ID NO:22 CLQYLTC; SEQ ID NO:23 CLEHTC; SEQ ID NO:24 CLQYLTQC; SEQ ID NO:25 CLEHLTQC; SEQ ID NO:26 CPIAGSSQQC; SEQ ID NO:37 CPICGSSQQC; SEQ ID NO:27 CPLCGSAQHC; SEQ ID NO:28 CPLAGSAQHC; SEQ ID NO:29 CNHEPRFLSC; SEQ ID NO:30 CDYRHKFSLC; SEQ ID NO:31 CLNLQNLC; SEQ ID NO:32 CLKLQNLC; SEQ ID NO:33 CNLSESQLC; and SEQ ID NO:34 CKLSESQLC.