Patent ID: 8986701
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K,C12Y

Abstract:
1. A method of treating at least one of a cancer tumor and cancer cells in a patient wherein the cancer tumor/cancer cells is supplied by a tumor vasculature, comprising the step of: contacting at least one blood vessel supplying a tumor in the patient with a therapeutically effective amount of a conjugate selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:4, the conjugate comprising an annexin having an enzyme operatively attached thereto, wherein the annexin has the ability to specifically and stably bind to at least one of an external receptor and a binding site on an outer surface of a tumor vasculature endothelial cell, wherein the at least one of an external receptor and a binding site is specific to the tumor vasculature endothelial cell, and wherein the enzyme is able to convert a prodrug into an active drug, and whereby the conjugate is maintained on the outer surface of the tumor vasculature endothelial cell; contacting the at least one blood vessel having the conjugate maintained thereon with a therapeutically effective amount of a selenomethionine prodrug, the selenomethionine prodrug comprising a substrate for the enzyme of the conjugate whereby the selenomethionine prodrug is converted into an active anticancer drug by the enzyme of the conjugate in close proximity to the tumor vasculature endothelial cell, and wherein the active anticancer drug is carried across the artery wall and travels inside the tumor vasculature endothelial cell by diffusion and permeation flow and directly causes death of the tumor vasculature endothelial cell.