Patent ID: 6156727
Filing Date: 2000-12-05
Classification: A01K,A61K,C07K

Abstract:
An anti-atherosclerotic synthetic peptide, said peptide being an amphipathic helical peptide compared with human apoA-I, characterized by having at least 4 of the following 8 properties: a tandem repeating class A amphipathic helix linked by a proline which forms an optimal arrangement for lipid association, has lipid bilayer membrane stabilizing properties, inhibits HIV-I GP41-induced cell fusion, inhibits neutrophil activation, inhibits bovine serum albumin-induced lysis of fatty acid-containing vesicles, stimulates human placental lactogen synthesis, effluxes phospholipid and cellular cholesterol from cholesterol-laced cells, and competes with HDL for binding to cells; wherein said peptide has the sequence shown in SEQ ID NO. 3.