Patent ID: 7652055
Filing Date: 2010-01-26
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein X—Y is CH(R R R R Ar is phenyl, n is 0, 1, 2, 3 or 4; and o is 0, 1, 2, 3 or a pharmaceutically active salt thereof, with the exception of the following compounds: 2-(4-benzyl-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(4-phenethyl-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(2,3,6-trimethyl-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(2,6-dichloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(2-chloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(biphenyl-2-yloxymethyl)-4,5-dihydro-1H-imidazole, 2-(2,3-dichloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(biphenyl-4-yloxymethyl)-4,5-dihydro-1H-imidazole, 2-(2-methoxy-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(naphthalen-2-yloxymethyl)-4,5-dihydro-1H-imidazole, 2-(4-chloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(3-trifluoromethyl-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(2,4-dichloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-[1-(2-benzyloxy-phenoxy)-2-phenyl-ethyl]-4,5-dihydro-1H-imidazole, 2-(2-cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-(3-chloro-phenoxymethyl)-4,5-dihydro-1H-imidazole, 2-phenoxymethyl-4,5-dihydro-1H-imidazole, 2-phenethyl-4,5-dihydro-1H-imidazole, N-(3-chloro-2-methyl-phenyl)-N′-(4,5-dihydro-1H-imidazol-2-yl)-hydrazine, benzyl-(4,5-dihydro-1H-imidazol-2-yl)-amine, 2-(3,4-dichloro-phenylsulfanylmethyl)-4,5-dihydro-1H-imidazole, 2-(2,4-dichloro-benzylsulfanyl)-4,5-dihydro-1H-imidazole, 2-(3-chloro-4-propoxy-benzylsulfanyl)-4,5-dihydro-1H-imidazole, 2-(3-nitro-4-propoxy-benzylsulfanyl)-4,5-dihydro-1H-imidazole, 2-benzylsulfanyl-4,5-dihydro-1H-imidazole, 2-(2-chloro-6-fluoro-benzylsulfanyl)-4,5-dihydro-1H-imidazole, 2-(3-chloro-4-ethoxy-benzylsulfanyl)-4,5-dihydro-1H-imidazole, 2-(2,6-dichloro-benzylsulfanyl)-4,5-dihydro-1H-imidazole, and 2-(3,4-dichloro-benzylsulfanyl)-4,5-dihydro-1H-imidazole.