Patent ID: 6492370
Filing Date: 2002-12-10
Classification: C07C,C07D

Abstract:
A compound represented by the following general formula [I] or a salt thereof whereinR1 is hydrogen, lower alkyl, an aromatic group, RAâ€”COâ€”, RCâ€”Sâ€” or a group of the following formula [II]; R2, R3 and R4, being the same or different, are hydrogen, lower alkyl, lower alkenyl cycloalkyl, cycloalkenyl or an aromatic group; when R4 is lower alkyl, terminal carbon of the lower alkyl can join with carbon to which the alkyl is bonded to form a cycloalkyl ring; R5 and R6, being the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl or an aromatic group; when both R5 and R6 are lower alkyl, they can join each other to form a nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring, and the heterocyclic ring can be substituted by lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, an aromatic group or RAâ€”COâ€”; R7 is hydrogen, lower alkyl, cycloalkyl, hydroxy, mercapto, phenyl, RBâ€”Oâ€”, RCâ€”Sâ€”, RDâ€”COSâ€”, REâ€”OCOâ€”, RFâ€”N(RG)â€” or â€”CONHOH; or R7 can join with sulfur adjacent to A1 to form a nonaromatic heterocyclic ring with said sulfur adjacent to A1 in the ring, and wherein the ring optionally contains a carbonyl in the ring; A1 is lower alkylene; A2 is lower alkylene; each lower alkyl defined above can be substituted by hydroxy, a nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring, cycloalkyl, cycloalkenyl, adamantyl, an aromatic group, phthalimido, guanidino which can be substituted by lower alkylsulfonyl or aromatic sulfonyl, RAâ€”COâ€”, RBâ€”Oâ€”, RCâ€”Sâ€”, RDâ€”COSâ€”, REâ€”OCOâ€”, RFâ€”N(RG)â€”, RHâ€”N(RJ)COâ€”, RKâ€”CONHâ€” or â€”CONHOH; each lower alkenyl defined above can be substituted by hydroxy, lower alkyl, lower alkoxy, cycloalkyl, cycloalkenyl or an aromatic group; each cycloalkyl defined above can be substituted by lower alkyl, hydroxy, oxo or REâ€”OCOâ€”; each aromatic group defined above can be substituted by lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, halogen, nitro, an aromatic group, lower alkylsulfonyl, aromatic sulfonyl, REâ€”OCOâ€”, RFâ€”N(RG)â€” or RKâ€”CONHâ€”; the nonaromatic heterocyclic ring having nitrogen and/or oxygen in the ring defined above can be substituted by lower alkyl, cycloalkyl, an aromatic group or RAâ€”COâ€”, and the lower alkyl can be substituted by hydroxy, cycloalkyl, cycloalkenyl, an aromatic group, RAâ€”COâ€”, RBâ€”Oâ€”, REâ€”OCOâ€” or RFâ€”N(RG)â€”; RA is lower alkyl, halogen-lower alkyl, an aromatic group, lower alkoxy, aromatic-lower alkoxy or RFâ€”N(RG)â€”; RB is lower alkyl or an aromatic group; RC is hydrogen, lower alkyl or an aromatic group; RD is lower alkyl or an aromatic group; RE is hydrogen, lower alkyl or an aromatic group; RF and RG, being the same or different, are hydrogen lower alkyl, cycloalkyl or an aromatic group; RH and RJ, being the same or different, are hydrogen, lower alkyl, cycloalkyl or an aromatic group; RK is lower alkyl, lower alkoxy or an aromatic group.