Patent ID: 6723498
Filing Date: 2004-04-20
Classification: C12Q,G01N

Abstract:
A method for screening compounds to identify candidate compounds for increasing the drug resistance of a cell, the method comprising:a) determining the level of expression of Chk1 comprising the nucleic acid sequence of SEQ ID NO:1 in a cell in the presence of a selected compound; b) determining the level of expression of Chk1 comprising the nucleic acid sequence of SEQ ID NO:1 in the cell in the absence of the selected compound; and c) identifying the selected compound as a candidate compound for increasing the drug resistance of the cell if the level of expression of Chk1 comprising the nucleic acid sequence of SEQ ID NO;1 in the cell in the presence of the selected compound is greater than the level of expression of Chk1 comprising the nucleic acid sequence of SEQ ID NO:1 in the cell in the absence of the selected compound.