Patent ID: 6204292
Filing Date: 2001-03-20
Classification: A61P,C07C,C07F

Abstract:
A compound of formula I: ##STR17##whereinR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.7, R.sup.8, R.sup.9, and R.sup.10 are each independently hydrogen, carboxy, tetrazolyl, --SO.sub.2 OH, --PO(OH).sub.2, --B(OH).sub.2, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkoxy, halo(C.sub.1 -C.sub.6)alkyl, hydroxy(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkanoyloxy, (C.sub.1 -C.sub.6)alkoxycarbonyl, cyano, halo, --CONR.sub.a R.sub.b, --NR.sub.c R.sub.d, --SR.sub.e, aryl, heteroaryl, aryl(C.sub.1 -C.sub.6)alkyl, diaryl(C.sub.1 -C.sub.6)alkyl, or heteroaryl(C.sub.1 -C.sub.6)alkyl, wherein any aryl or heteroaryl may optionally be substituted with 1, 2 or 3 substituents selected from the group consisting of halo, hydroxy, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkanoyloxy, (C.sub.1 -C.sub.6)alkoxycarbonyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, and carboxy;R.sup.5 is carboxy, tetrazolyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, --SO.sub.2 OH, --B(OH).sub.2, or --PO(OH).sub.2 ;R.sup.6 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, aryl, aryl(C.sub.1 -C.sub.6)alkyl, heteroaryl, heteroaryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, or (C.sub.1 -C.sub.6)alkanoyl;X is absent;each R.sub.a R.sub.b and R.sub.e is independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, aryl, heteroaryl, benzyl, or phenethyl;each R.sub.c or R.sub.d is independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkanoyl, aryl, heteroaryl, benzyl, or phenethyl; or R.sub.c and R.sub.d together with the nitrogen to which they are attached are triazolyl, imidazolyl, oxazolidinyl, isoxazolidinyl, pyrrolyl, morpholino, piperidino, pyrrolidino, pyrazolyl, indolyl, or tetrazolyl;or a pharmaceutically acceptable salt or prodrug thereof; wherein at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.9, and R.sup.10 is carboxy, tetrazolyl, --SO.sub.2 OH, --PO(OH).sub.2, or --B(OH).sub.2.