Patent ID: 6762190
Filing Date: 2004-07-13
Classification: A61P,C07D

Abstract:
A compound of the formula I whereinA and B which are individually selected from the group consisting of hydrogen, (C1-C18)-alkyl, (C3-C4)-cycloalkyl, (C3-C14)-cycloalkyl-(C1-C8)-alkyl-, (C5-C14)-aryl, (C5-C14)-aryl-(C1-C8)-alkyl-, fluorine, chlorine, bromine, cyano, trifluoromethyl, nitro, hydroxycarbonyl-, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl-, (C1-C6)-alkylcarbonyl-, (C5-C14)-arylcarbonyl-, (C1-C6)-alkylaminocarbonyl-, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy, (C5-C14)-aryl-(C1-C8)-alkylcarbonyl-, (C1-C6)-alkanoylamino-, (C1-C6)-alkylamino-, di-((C1-C6)-alkyl)amino-, (C1-C6)-alkylsulfonyl- and aminosulfonyl-, or A and B bonded to the thiophene ring together with the carbon atoms to which they are bonded form an aromatic or non-aromatic ring system that is fused to the thiophene ring; X is selected from the group consisting of (C3-C6)-alkanediyl, (C3-C6)-alkenediyl and (C3-C6)-alkynediyl, where in all these one carbon atom can be replaced by a heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and where all these can be substituted by one or two of hydroxy and/or A; Y is selected from the group consisting of a direct bond, â€”S(O)2â€”, â€”C(O)â€”, â€”C(O)â€”Oâ€”, â€”S(O)2â€”N(R)3â€²)â€” and â€”C(O)â€”N(R3)â€”, the divalent residues of Y are bonded to R1 via the free bond on their right side; R1 is selected from the group consisting of (C1-C18)-alkyl, (C3-C14)-cycloalkyl, (C3-C14)-cycloalkyl-(C1-C8)-alkyl, (C5-C14)-aryl and (C5-C14)-aryl-(C1-C8)-alkyl, where the alkyl, cycloalkyl and aryl are unsubstituted or substituted with one to three members of the groups consisting of fluorine, chlorine, bromine, cyano, trifluoromethyl, nitro, hydroxycarbonyl-, (C1-C6)-alkyl, (C5-C14)-aryl, (C5-C14)-aryl-(C1-C8)-alkyl-, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl-, (C1-C6)-alkoxycarbonyl-, (C1-C6)-alkylcarbonyl-, (C1-C6)-alkylaminocarbonyl-, (C1-C6)-alkoxy-(C1-C6)-alkoxy-, (C5-C14)-arylcarbonyl-, (C5-C14)-aryl-(C1-C8)-alkylcarbonyl-, (C1-C6)-alkanoylamino-, (C5-C14)-arylsulfonylamino-, (C1-C6)-alkylsulfonylamino-, (C1-C6)-alkylamino-, di-((C1-C6)-alkyl)amino-, (C1-C6)-alkylsulfonyl-, (C1-C6)-alkylaminosulfonyl-, (C5-C14)-arylaminosulfonyl-, (C5-C14)-aryl-(C1-C8)-alkylaminosulfonyl-, (C5-C14)-arylsulfonyl-, (C5-C14)-aryl-(C1-C8)-alkylsulfonyl- and a residue of a saturated or partially unsaturated, monocyclic or polycyclic 3 -membered to 14 membered ring which can contain one to four ring heteroatoms from the group consisting of nitrogen, oxygen and sulfur and unsubstituted or substituted with one or two members of the group consisting of A, &boxH;O and &boxH;S; R2 is selected from the group consisting of â€”C(O)R4, â€”C(S)R4, â€”S(O)2R4, â€”P(O)R4R4 and a residue of a saturated or unsaturated 4-membered to 8-membered heterocycle which contains one to four heteroatoms from the group consisting of nitrogen, oxygen and sulfur; R3 and R3â€² which are individually selected from the group consisting of hydrogen, (C1-C18)-alkyl, (C3-C14)-cycloalkyl, (C3-C14)-cycloalkyl-(C1-C8)-alkyl-, (C3-C14)-cycloalkyl-(C1-C8)-alkyl-, (C5-C14)-aryl and (C5-C14)-aryl-(C1-C8)-alkyl-; R4 and R4â€² which are individually selected from the group consisting of hydroxy, (C1-C8)-alkoxy, (C5-C14)-aryl-(C1-C8)-alkoxy-, (C1-C8)-alkylcarbonyloxy-(C1-C4)-alkoxy-, (C5-C14)-aryl-(C1-C8)-alkylcarbonyloxy-(C1-C8)-alkoxy- and â€”NR5R5â€²; R5 and R5â€² which are individually selected from the group consisting of hydrogen, (C1-C18)-alkyl, (C3-C14)-cycloalkyl, (C3-C14)-cycloalkyl-(C1-C8)-alkyl-, (C5-C14)-aryl and (C5-C14)-aryl-(C1-C8)-alkyl-, or R5 and R5â€² together with the nitrogen atom to which they are bonded form a saturated or unsaturated 4-membered to 8-membered ring system which in addition to the nitrogen atom to which R5 and R5â€² are bonded can contain one to three ring heteroatoms from the group consisting of nitrogen, oxygen and sulfur; n is zero to two; in all their steroisomeric forms and mixtures thereof in all ratios, and its pharmaceutically acceptable salts.