Patent ID: 6117653
Filing Date: 2000-09-12
Classification: A61K,A61P,C07K,C12N,Y02A,Y10S

Abstract:
A vaccine comprising a particle comprising a polypeptide, wherein the polypeptide is prepared by recombinant DNA processes from gene constructs in cultured host cells, and wherein the polypeptide comprises:a first amino acid sequence, wherein the first amino acid sequence comprises all or a portion of the sequence of amino acids 1 to 47 of an HBV pre-S1 peptide and exhibits the antigencity of an HBV pre-S1 epitope; anda second amino acid sequence, wherein the second amino acid sequence comprises all or a portion of an HBV surface antigen peptide having the capacity to be assembled into particles; andwherein the polypeptide:does not comprise the entire sequence of amino acids of an HBV pre-S1 peptide;exhibits antigenicity of the HBV pre-S1 epitope; andwhen produced from the gene constructs in the cultured host cells, retains the capacity of the second amino acid sequence to be assembled into particles.