Patent ID: 6462211
Filing Date: 2002-10-08
Classification: A61P,C07J

Abstract:
A compound selected from the group consisting of a compound of the formula wherein X is halogen, R2 is unsaturated or saturated hydrocarbon of 1 to 6 carbon atoms, D is the remainder of an unsaturated or saturated pentagonal or hexagonal ring unsubstututed or substituted with at least one member of the group consisting of â€”OH, â€”Oâ€”(CH2)mâ€”Alk, â€”OCOâ€”Alk, â€”Oâ€”(CH2)mâ€”Ar, â€”Oâ€”COAr, â€”Oâ€”(CH2)mâ€”Het, â€”OCOâ€”Het, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms alkynyl of 2 to 6 carbon atoms, m is an integer from 0 to 3, Z is â€”(CH2)1â€” or â€”CH&boxH;CHâ€”(CH2)1, 1 is 1 to 4, 1â€² is 1 or 2, Alk is unsaturated or saturated alkyl or cycloalkyl of up to 12 carbon atoms, Ar is carbocyclic aryl of 6 to 18 carbon atoms, Het is unsaturated or saturated, aromatic or non-aromatic heterocyclic of 1 to 9 carbon atoms and 1 to 5 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur, Râ€²7 is selected from the group consisting of n is an integer from 2 to 8, Hal is halogen, P is a protective group, Y is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€” and â€”NHâ€”, R3 and R4 are individually selected from the group consisting of hydrogen, â€”(CH2)mâ€”Ar, â€”(CH2)mâ€”Het and â€”(CH2)mâ€”Alk or taken together with the nitrogen form an unsaturated or saturated, aromatic or non-aromatic mono or polycyclic heterocycle of 3 to 15 members containing 1 to 3 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, Râ€²5 is selected from the group consisting of â€”OH, â€”Oâ€”(CH2)mâ€”Alk, â€”Oâ€”COâ€”Alk, â€”Oâ€”(CH2)mâ€”Ar, â€”Oâ€”COâ€”Ar, â€”Oâ€”(CH2)mâ€”Het and â€”Oâ€”COâ€”Het and Râ€²6 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and alkenyl and alkynyl of 2 to 6 carbon atoms, or Râ€²5 and Râ€²6 form oxo or &boxH;NOH or together with the carbon form a member selected from the group consisting of