Patent ID: 6080194
Filing Date: 2000-06-27
Classification: A61B,A61F,A61L

Abstract:
A template for the repair of cartilage defects leading to the regeneration of hyaline-like cartilage, the template comprising:a) a first layer comprising a dense collagen membrane having a pore size of less than 1 micrometer which is cross-linked with a non-cytotoxic agent to increase strength and lengthen resorption time, to provide a barrier against movement of cells from the subchondral plate, the membrane being sufficiently permeable to allow the passage therethrough of fluids, nutrients, cytokines, and other endogenous factors necessary for healing; andb) a second layer secured to the first layer and comprising a porous collagen matrix having pore size of 50 to 200 micrometers, which permits the ingrowth of cells.