Patent ID: 7122525
Filing Date: 2006-10-17
Classification: A61K,A61P

Abstract:
1. A compound of formula I: wherein (B) is a therapeutic drug; (L) is a linker which forms linkage groups with rifamycin derivative (A) and therapeutic drug (B), wherein said linker (L) is described by any of formulas XXI–XXV: wherein Z Z R R R Y o, p, s, t, u, v, and w are each, independently, 0 or 1; R R R X (A) is a rifamycin derivative of formula II: wherein each methine proton, methylene proton, and methyl proton of formula II is optionally substituted by —OH or —OR*; R represents a hydrogen atom, a hydroxyl group or —OR*; R ring G is selected from formulas III–XI: R′ represents a hydrogen atom or R*; X H H R R each R each R g represents an integer between 1 and 3; R X R k represents an integer between 1 and 4; m represents 0 or 1; R n represents an integer between 1 and 4; X R* is a bond in a linkage group between (A) and (L).