Patent ID: 6602849
Filing Date: 2003-08-05
Classification: A61K,C07K

Abstract:
A compound of the formula (I), or a pharmaceutically acceptable salt thereof,wherein,Y and Z for each occurrence are each independently a D- or L-natural or unnatural &agr;-amino acid; n for each occurrence is independently 0 to 50, provided that both n cannot be 0 at the same time; m is 0 or an integer from 1 to 10; a is H or R1; b is OH, â€”OR1 or â€”NR9R9; or a is taken together with b to form an amide bond; R1 is independently H, (C1-C4)alkyl or aryl-(C1-C4)alkyl; R2 is H or an optionally substituted moiety selected from the group consisting of (C1-C4)alkyl, phenyl, phenyl-(C1-C4)alkyl and heterocyclyl-(C1-C4)alkyl; where the optionally substituted moiety is optionally substituted by one or more substituents each independently selected from the group consisting of (C1-C4)alkyl, (C3â€”C8)cycloalkyl, â€”Oâ€”R6, â€”S(O)qâ€”R7, â€”N(R9R9), â€”NHCOâ€”R6, â€”NHSO2R9, â€”CO2R9, â€”CONR9R9 and â€”SO2NR9R9, where q is 0, 1, 2 or 3; R3 and R4 are each independently H, halo or an optionally substituted moiety selected from the group consisting of (C1-C4)alkyl, (C3-C8)cycloalkyl, aryl and aryl-(C1-C4)alkyl; where the optionally substituted moiety is optionally substituted by one or more substituents selected from the group consisting of OH, (C1-C4)alkyl, (C1-C4)alkoxy, aryloxy, aryl-(C1-C4)alkoxy, â€”NR9R9, COOH, â€”CONR9R9 and halo; or R3 and R4 are taken together with the carbons to which they are attached to form optionally substituted aryl, where the aryl is optionally substituted by one or more substituents each independently selected from the group consisting of OH, (C1-C4)alkyl, (C1-C4)alkoxy, aryloxy, aryl-(C1-C4)alkoxy, â€”NR9R9, COOR5, â€”CONR9R9 and halo; R5 for each occurrence is independently H, or an optionally substituted moiety selected from the group consisting of (C1-C4)alkyl and aryl-(C1-C4)alkyl, where the optionally substituted moiety is optionally substituted by one or more substituents each independently selected from the group consisting of (C1-C4)alkyl, OH, (C1-C4)alkoxy, aryloxy, NO2, aryl-(C1-C4)alkoxy, â€”NR9R9, COOH, â€”CONR9R9 and halo; R6 for each occurrence is independently selected from the group consisting of H, (C1-C4)alkyl, (C1-C4)alkoxy, aryl-(C1-C4)alkyl and aryl-(C1-C4)alkoxy; R7 is H when q is 3 or, R7 for each occurrence is independently selected from the group consisting of (C1-C4)alkyl, aryl and aryl-(C1-C4)alkyl when q is 0, 1 or 2; and R9 for each occurrence is independently selected from the group consisting of H, NO2, (C1-C4)alkyl, aryl and aryl-(C1-C4)alkyl.