Patent ID: 9061995
Filing Date: 2015-06-23
Classification: A61K,A61P,C07D,C07K,Y02A

Abstract:
1. A cell-binding agent-drug conjugate of formula (II) wherein: CB represents a cell-binding agent; D represents a cytotoxic drug linked to the cell-binding agent by a disulfide, thioether, thioester, peptide, hydrazone, ester, ether, carbamate, or amide bond; R R l, m and n are 0 or an integer from 1 to 4; Z is F1-E1-P-E2-F2 unit in which E1 and E2 are the same or different and are C═O, O, or NR Y represents a carbonyl, thioether, amide, disulfide, or hydrazone group; and q represents an integer from 1 to 20.