Patent ID: 9115198
Filing Date: 2015-08-25
Classification: A61P,C07K

Abstract:
1. A method of isolating a monoclonal antibody that binds to domain 1 of human ICAM-1 without inhibiting the binding of human ICAM-1 to human leukocyte function antigen-1 (LFA-1) comprising performing a competitive binding assay between the monoclonal antibody and the antibody produced by a hybridoma deposited as an accession number KCLRF-BP-00198, wherein the monoclonal antibody inhibits binding of the antibody produced by the hybridoma by at least 50%, and binding to domain 1 of human ICAM-1 without inhibiting the binding of human ICAM-1 is confirmed by a mixed lymphocyte proliferation assay, and thereby isolating the monoclonal antibody.