Patent ID: 7405233
Filing Date: 2008-07-29
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A method of modulating premature translation termination and/or nonsense-mediated mRNA decay in a cell in vitro, comprising contacting a cell exhibiting premature translation termination and/or nonsense-mediated mRNA decay with an effective amount of a compound having the structure: or a pharmaceutically acceptable salt, hydrate, clathrate or stereoisomer thereof, wherein: X is C(═O), C(═S), S, S(═O) or S(O) Y is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted cycloalkyl; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, or substituted or unsubstituted cycloalkylalkyl; n is an integer ranging from 0-4; R and R