Patent ID: 8084734
Filing Date: 2011-12-27
Classification: B29C,H01J,Y10T

Abstract:
1. A method of detecting a sample, comprising: subjecting the sample to LDI-MS, wherein the sample is selected from the group consisting of proteins, peptides, pharmaceuticals, explosives, synthetic polymers, and molecules having a molecular weight less than about 6000 Daltons, and wherein the LDI-MS is performed using a LDI-MS device which comprises a laser patterned surface, wherein the laser patterned surface is prepared by subjecting a silicon surface, in liquid, to repeated pulsed high-power laser irradiation selected from picosecond laser irradiation and femtosecond laser irradiation, wherein an array of microcolumns are generated on the silicon surface and the microcolumns have average structural features of less than 10 micrometers in size, wherein the average structural features are selected from column height, diameter and periodicity, wherein the sample is subjected to LDI-MS at a laser fluence of at least about 30 mJ/cm