Patent ID: 6191127
Filing Date: 2001-02-20
Classification: A61P,C07D

Abstract:
A compound of Formula I ##STR10##wherein ##STR11##is a double bond;X is --O-- or --S(O).sub.m --;R.sup.1 and R.sup.2, independently of one another, are each hydrogen, halogen, S(O).sub.n --R.sup.7, OR.sup.7, COOR.sup.7, NR.sup.7 R.sup.8, C(.dbd.NR.sup.7)--NHR.sup.8, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or --S--C(.dbd.NR.sup.7)--NHR.sup.8 ;R.sup.3 and R.sup.4, independently of one another, are each hydrogen, C.sub.1-12 alkyl, phenyl, CO--NR.sup.9 R.sup.10, CSNR.sup.9 R.sup.10, COR.sup.9, CSR.sup.9, COOR.sup.9, OH, or O--C.sub.1-6 alkyl;R.sup.5 is halogen, C.sub.1-8 alkoxy, S(O).sub.p --C.sub.1-6 alkyl, C.sub.1-8 alkylcarbonyl, methyl, ethyl, propyl, isopropyl, n-butyl, sec-pentyl, tert-pentyl, neo-pentyl, n-hexyl, sec-hexyl, heptyl, octyl, C.sub.3-10 cycloalkyl, phenyl or a C.sub.1-8 alkyl radical, which is substituted with phenyl, halogen, hydroxy, S(O).sub.n R.sup.11, NO.sub.2, OR.sup.11, COOR.sup.11, NR.sup.11 R.sup.12, cyano, --C(.dbd.NR.sup.11)--NHR.sup.12 or --S--C(.dbd.NR.sup.11)--NHR.sup.12 ;R.sup.6 is hydrogen or C.sub.1-3 alkyl, which optionally together with R.sup.5 forms a 3-, 4- or 5-membered spirocyclic compound;R.sup.7, R.sup.8 and R.sup.11, R.sup.12, being the same or different, are each hydrogen, C.sub.1-6 alkyl, phenyl or C.sub.3-7 cycloalkyl;R.sup.9 and R.sup.10, independently of one another, are each hydrogen, phenyl, benzyl, C.sub.3-7 cycloalkyl or C.sub.1-6 alkyl; andm, n, or p is 0, 1 or 2; ora physiologically compatible salt thereof,with the proviso that when R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are each H, R.sup.5 is not C.sub.1-8 alkoxy.