Patent ID: 8808684
Filing Date: 2014-08-19
Classification: A61K,A61P,C07H,C07K,C12N

Abstract:
1. A method of specifically transducing an epidermal growth factor receptor (EGFR)-expressing cell in tissue containing a population of cells, the method comprising: introducing a recombinant adeno-associated virus (AAV) vector directly to cells in the population, wherein EGFR-expressing cells are transduced with the vector and non-EGFR-expressing cells are not transduced with the vector, wherein the vector comprises the AAV subtype 6 (AAV6) viral genome, or a functional portion thereof, and a heterologous nucleic acid sequence capable of being expressed by the EGFR-expressing cell, wherein the transduced EGFR-expressing cells contain 4.6×10 wherein the heterologous nucleic acid encodes a gene that increases the EGFR-expressing cell's susceptibility to a drug or cytotoxic agent.