Patent ID: 6630123
Filing Date: 2003-10-07
Classification: A61K,Y10S

Abstract:
A method for selectively accumulating a receptor-dependent radiolabeled compound inside target cells in a patient, wherein the target cells are selected from the group consisting of tumor cells and angiogenic cells, wherein the target cells express receptors for the compound, comprising:(a) selecting a radiolabeled compound from a group comprising analogs and derivatives of receptor-dependent peptides wherein the compound is bound to a radioisotope and wherein the compound binds to the same target cell receptor and accumulates in the target cell in a qualitatively similar manner as that of the receptor-dependent peptide, wherein the receptor-dependent peptide is selected from a group consisting of nerve growth factor, fibroblast growth factor, epidermal growth factor, platelet-derived growth factor, vascular endothelial growth factor, cholecystokinin, vasoactive intestinal peptide, gastrin-releasing peptide, leukemia inhibitory factor, somatostatin, oxytocin, bombesin, calcitonin, arginine vasopressin, angiotensin II, atrial natriuretic peptide, insulin, glucagon, prolactin, growth hormone, gonadotropin, thyrotropin-releasing hormone, growth hormone-releasing hormone, gonadotropin-releasing hormone, corticotropin-releasing hormone, interleukins, interferons, transferrin, substance P, neuromedin, neurotensin, neuropeptide Y; and (b) comprising administering a dose of the radiolabeled compound to the patient by infusion during a period greater than two hours; wherein the resulting residence time of the radiolabeled compound in the target cells is at least one and one-half (1.5) times the residence time of the radiolabeled compound in the target cells that would result from a bolus administration of the same total dose of the same radiolabeled compound to the patient.