Patent ID: 7670804
Filing Date: 2010-03-02
Classification: A61K,A61P,B82Y,C07K,Y10S

Abstract:
1. A method of delivering a diagnostic and/or therapeutic agent to a CSAp-expressing tumor comprising: a) obtaining an anti-CSAp antibody or fragment thereof, wherein the anti-CSAp antibody binds to the same epitope of CSAp as an Mu-9 antibody, wherein the Mu-9 antibody comprises the light chain complementarity determining region (CDR) sequences CDR1 (RSSQSIVHSNGNTYLE, SEQ ID NO: 1), CDR2 (KVSNRFS, SEQ ID NO:2) and CDR3 (FQGSRVPYT, SEQ ID NO:3) and the heavy chain CDR sequences CDR1 (EYVIT, SEQ ID NO:4), CDR2 (EIYPGSGSTSYNEKFK, SEQ ID NO:5) and CDR3 (EDL); b) conjugating said anti-CSAp antibody or fragment to at least one diagnostic and/or therapeutic agent; and e) administering the conjugated anti-CSAp antibody or fragment thereof to a subject in need thereof wherein said administration is effective to deliver said at least one diagnostic or therapeutic agent to said CSAp-expressing tumor.