Patent ID: 7300668
Filing Date: 2007-11-27
Classification: A61J,A61K,B33Y

Abstract:
1. A dosage form comprising: a three-dimensionally printed innermost region comprising a first regional concentration of at least one Active Pharmaceutical Ingredient; and plural three-dimensionally printed non-innermost regions in nested arrangement and comprising: a) one or more nested internal regions each comprising a respective regional concentration of at least one Active Pharmaceutical Ingredient, wherein an internal region completely surrounds and is in contact with the innermost regions, and any other internal region present completely surrounds another internal region located to the interior thereof; and b) an outermost region completely surrounding an internal region and comprising a respective regional concentration of at least one Active Pharmaceutical Ingredient, wherein the internal and outermost regions are in nested arrangement, the regional concentration of Active Pharmaceutical Ingredient in a region is different from the regional concentration of Active Pharmaceutical Ingredient in another region adjacent to it, the regional concentration of Active Pharmaceutical Ingredient in an internal region is non-zero, the regional concentration of Active Pharmaceutical Ingredient in plural regions is non-zero, and the respective regional concentrations are selected so that the at least one Active Pharmaceutical Ingredient is released in approximately a zero-order release.