Patent ID: 7964568
Filing Date: 2011-06-21
Classification: A61K,A61P,C08B

Abstract:
1. A process for the preparation of a high molecular weight iron-saccharidic complex, said complex suitable for parenteral administration in human or veterinary medicine, comprising: (1) contacting in a substantially aqueous medium in order to form a reaction mixture having a pH: (2) adding a base to increase the pH of said mixture to a complex assembly point; and (3) thereafter heating said mixture for a period of time sufficient to form said iron-saccharidic complex having an absolute weight average molecular weight of about 75,000 Daltons or more; and further comprising the addition, to the reaction mixture prior to the iron-saccharidic complex achieving its final molecular weight, of at least one sugar or sugar derivative molecular weight moderating additive in one or more of steps (1), (2) or (3) in an amount sufficient to cause the molecular weight of the high molecular weight iron-saccharidic complex to be lower than it would otherwise be in the absence of said additional amount; provided that the additive is different from the compound originally used in step (1)(i); and wherein said sugar derivatives: (a) are saccharides selected from the group consisting of acids, salts, methyl esters, acetates, amines, alcohols and mixtures thereof; and (b) substantially exclude polysaccharides.