Patent ID: 6312738
Filing Date: 2001-11-06
Classification: C07D

Abstract:
A process for the production of an azadirachtin rich aqueous solution including the steps of:(i) de-oiling by pressing whole neem seeds or ground or otherwise comminuted neem seeds to remove a first proportion of the oil content thereof;(ii) extracting the de-oiled neem seeds with a polar organic solvent in which azadirachtin is soluble but in which polysaccharides and proteins are not substantially soluble to form an organic solution of azadirachtin and the remaining oil;(iii) partitioning the organic solution against water to form an aqueous solution of azadirachtin and the remaining oil; and(iv) separating the remaining oil from the aqueous solution to form an azadirachtin rich aqueous solution and a bitter oil fraction.