Patent ID: 6399350
Filing Date: 2002-06-04
Classification: C12N,C12Q,G01N

Abstract:
A method for modulating the interaction of a KUZ polypeptide with a natural KUZ binding target comprising the step of exposing a mixture of said polypeptide and said binding target to an agent that modulates the binding of said polypeptide to said binding target, said polypeptide comprising an amino acid sequence selected from the group consisting of residues 320-673 of SEQ ID NO:2, residues 212-454 of SEQ ID NO:4, SEQ ID NO:6, and residues 213-455 of SEQ ID NO:8, wherein the agent is selected from the group consisting of an antibody specific to the polypeptide, a dominant negative fragment of said polypeptide and a metalloprotease inhibitor, and the binding target is a protease substrate specifically cleaved by the polypeptide.