Patent ID: 9090607
Filing Date: 2015-07-28
Classification: A61P,C07D

Abstract:
1. A process for preparing tiotropium bromide comprising: i) reacting scopine oxalate (X) with diethylamine in an inert solvent to form scopine (II) ii) reacting scopine and methyl di-(2-dithienyl)glycolate (MDTG) in the presence of an inorganic base, and in an inert solvent to form N-demethyltiotropium; iii) reacting N-demethyltiotropium with bromomethane in an inert solvent to form tiotropium bromide (I) iv) crystallizing tiotropium bromide in a mixture of methanol and acetone, and optionally thereafter, v) micronizing the tiotropium bromide so formed.