Patent ID: 8653053
Filing Date: 2014-02-18
Classification: A61K,A61P,A61Q

Abstract:
1. A medicated composition for topical application comprising active ingredients consisting of fluocinolone acetonide, hydroquinone and tretinoin, the composition being an emulsion obtainable by a process comprising the steps of: a) preparing an aqueous composition comprising water and at least one hydrophilic compound while heating at a temperature in the range of about 75° C. to about 80° C.; b) preparing a non-aqueous composition comprising at least two hydrophobic compounds while heating at a temperature in the range of about 75° C. to about 80° C.; c) combining the aqueous phase and non-aqueous compositions to form a mixture; d) adding at least one emulsifier to the mixture comprising the aqueous and non-aqueous compositions; e) adding tretinoin to the mixture comprising the aqueous and non-aqueous compositions; f) adding fluocinolone acetonide to the mixture comprising the aqueous and non-aqueous compositions; g) adding hydroquinone to the mixture comprising the aqueous and non-aqueous compositions, wherein the hydroquinone is added after adding the at least one emulsifier; and h) homogenizing the mixture to form the emulsion; wherein the aqueous composition comprises butylated hydroxytoluene and the non-aqueous composition comprises at least two hydrophobic compounds selected from the group consisting of cetyl alcohol, stearic acid, stearyl alcohol, methyl gluceth, methylparaben, propylparaben, and glycerin.