Patent ID: 8158152
Filing Date: 2012-04-17
Classification: A61K

Abstract:
1. A method of lyophilizing a hydrophilic pharmaceutical compound comprising: (a) dissolving the hydrophilic pharmaceutical compound in one or more hydrophilic solvents to form a solution, wherein the one or more hydrophilic solvents is a liquid in which the hydrophilic pharmaceutical compound dissolves; (b) adding one or more lipophilic non-solvents for the hydrophilic pharmaceutical compound to the solution, wherein: (c) freezing the hydrophilic pharmaceutical compound, the one or more hydrophilic solvents and the one or more lipophilic non-solvents of step (b) to yield a frozen result, the frozen result comprising a frozen portion; and (d) vacuum drying the frozen result of step (c) to yield a lyophilizate.