Patent ID: 9039997
Filing Date: 2015-05-26
Classification: B01L,G01N

Abstract:
1. A microfluidic system comprising: a base substrate; a sample holding layer formed on the base substrate, wherein the sample holding layer comprises a microfabricated cavity having an opening formed on a surface of the layer that faces opposite the substrate; a flow channel coupled to the cavity for delivering a reagent to the cavity; a control channel that intersects the flow channel and forms a deflectable membrane over at least a portion of the intersection, wherein actuation of the control channel causes deflection of the deflectable membrane to open or close the flow channel; and a removable cover having a cover layer with a first portion and a second portion, wherein the first portion and the second portion of the cover layer are coplanar when the cover layer is situated on the surface of the sample holding layer that faces opposite the substrate, and wherein the first portion of the cover layer is removable from the second portion of the cover layer to expose at least part of the opening in the microfabricated cavity while the second portion of the cover layer remains bonded to the sample holding layer.