Patent ID: 6380255
Filing Date: 2002-04-30
Classification: A61K,A61P,A61Q

Abstract:
A method for treating dermal atrophy of the skin, comprising the step of applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, said composition comprising at least one thyroid hormone compound together with a pharmacologically acceptable base for topical application, wherein said thyroid hormone compound binds to TR-&agr; or TR-&bgr; with an equilibrium dissociation constant, Kd, lower than 1 &mgr;M, whereinKd=(R)â€¢(L)/(RL), where (R) is the concentration of receptor, (L) is the concentration of ligand, and (RL) is the concentration of the receptor-ligand complex, and wherein said dermal atrophy of the skin is reduced.