Patent ID: 6864272
Filing Date: 2005-03-08
Classification: A61K

Abstract:
1. A method for inhibiting tumor growth comprising a) administering directly to a tumor site in a mammal an effective amount of an organelle and cytoskeleton crystallizing agent, wherein said crystallizing age is selected from the group consisting of p-Anisyl Blue Tetrazolium Chloride, p-Anisyl-p-Nitro Blue Tetrazolium Chloride, Thiazolyl blue, 2-2′-Benzothiazolyl-5-styiyl-3-(4-phthalhydrazidyl)tetrazolium chloride), Blue tetrazolium chloride, 2-(2′-Benzothiazolyl)-5-styryl-3-(4′-phthalhydrazidyl)-tetrazolium chloride, 5-Cyano-2,3-ditolyl tetrazolium chloride, 1-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, Distyryl nitroblue tetrazolium chloride, (1H)-tetrazole, Iodonitrotetrazolium chloride, Iodo Nitro Tetrazolium Violet Chloride, p-iodo nitrotetrazolium violet, (2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride, 2(p-iodophenyl)-p-nitropheny -5-phenyltetrazolium chloride, m-Nitro Blue Tetrazolium Chloride, m-Nitro Neotetrazolium Chloride, 2,2-bis(2-methoxyl-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyniethoxyphenyl)-2-(4-sulfopheny 2H-tetrazolium salt, tetrazolium bromide, thiazolyl blue tetrazolium bromide, (3→4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide), Nitro Blue Monotetrazolium Chloride, p-Nitro Blue Tetrazolium Chloride, (2,2′-di-nitrophenyl-5,5′-diphenyl-3,3′-(3,3′-dimethoxy-4,4′-diphenylene ditetrazolium chloride), Neotetrazolium chloride (2,2′,5,5′-Tetraphenyl-3,3′(p-diphenylene))-ditetrazolium chloride, Nitrotetrazolium Violet, Thiazolyl blue, tetrazolium blue chloride (3,3′→3,3′-dimethoxy(1.1′-biphenyl)-4,4′-diyll-bis(2,5-diphenyl-2H-tetrazolium)dichloride), o-Tolyl Tetrazolium Red, sodium 3′-[1-[(phenylamino)-carbonyl]-3,4tetrazolium]-bis(4-methoxy-6-nitro)benzine-sulfonic acid hydrate, Piperonyl Tetrazolium Blue, p-Tolyl Tetrazolium Red, Thiocarbamyl nitro blue tetrazolium chloride, 2,2′-di-p-nitrophenyl-5,5′-di-p-thiocarbamylphenyl-3,3′[3,3′-dimethoxy-4,4′-biphenylene]-ditetrazolium chloride, Tetranitroblue tetranitroblue tetrazolium chloride, 1,3,5-triphenyltetrazolium, Tetrazolium Red, 2,3,5-triphenyltetrazolium chloride, Tetrazolium violet, 2,3,5-Triphenyl-2-H-tetrazolium chloride, 2,5-diphen -3-[α-naphthyl]-tetrazolium chloride, 2,5-diphenyl-3-[1-naphthyl]-2H-tetrazolium chloride, Veratryl tetrazolium blue, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate, and 2,2-bis(2-methoxyl-4-notro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide, and wherein said crystallizing agent forms crystals in an organelle and/or cytoskeleton of tumor cells through a reaction catalyzed by cellular enzymes; and, b) administering to said mammal an effective amount of a chemotherapeutic agent.