Patent ID: 6534633
Filing Date: 2003-03-18
Classification: A61K,A61P,C07K

Abstract:
A soluble single-chain polyspecific binding protein comprising at least one single-chain T-cell receptor (sc-TCR) or fragment thereof covalently linked through a first peptide linker sequence to at least one single-chain antibody (sc-Ab) or fragment thereof, wherein the sc-TCR fragment specifically binds to a major histocompatibility (MHC) or human-leukocyte-associated antigen (HLA) complexed with peptide with at least about 70% affinity when compared to the specific binding of the full-length V-&agr; and V-&bgr; chain and further wherein the sc-Ab fragment specifically binds to the specific antigen with at least about 70% affinity when compared to the specific binding of the full-length immunoglobin chain.