Patent ID: 6143760
Filing Date: 2000-11-07
Classification: C07D

Abstract:
A compound of the formula: ##STR92## or the pharmaceutically acceptable salts thereof wherein: X is hydrogen, halogen, --OR.sub.1, C.sub.1 -C.sub.6 alkyl optionally substituted with up to three groups selected independently from halogen and hydroxy, or --NR.sub.2 R.sub.3 ;X is phenyl, naphthyl, 1-(5,6,7,8-tetrahydro)naphthyl or 4-(1,2-dihydro)indenyl, pyridinyl, pyrimidyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, benzofuranyl, or benzothienyl, each of which is optionally substituted with up to three groups selected from halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.6 alkylthio, hydroxy, amino, mono or di(C.sub.1 -C.sub.6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; orX represents a carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen, where the X carbocyclic group is optionally substituted with one or more groups selected from halogen, C.sub.1 -C.sub.6 alkoxy, mono- or di(C.sub.1 -C.sub.6)alkylamino, sulfonamide, aza(C.sub.3 -C.sub.7)cycloalkyl, C.sub.3 -C.sub.7 cycloalkylthio, C.sub.1 -C.sub.6 alkylthio, phenylthio, or a heterocyclic group;Y is lower alkyl having 1-8 carbon atoms optionally substituted with up to two groups selected from halogen, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, mono- or di(C.sub.1 -C.sub.6)alkylamino, sulfonamide, aza(C.sub.3-C.sub.7)cycloalkyl, C.sub.3 -C.sub.7 cycloalkylthio, C.sub.1 -C.sub.6 alkylthio, phenylthio, a heterocyclic group, --OR.sub.4, --NR.sub.5 R61 SR.sub.7, or optionally substituted aryl; orY is a carbocyclic group having from 3-7 members atoms, where up to three of which members are optionally hetero atoms selected from oxygen and nitrogen and where any member of the Y carbocyclic group is optionally substituted with halogen, --OR.sub.4, --NR.sub.5 R.sub.6, SR.sub.7, aryl or a heterocyclic group;R.sub.1 is hydrogen, lower alkyl having 1-6 carbon atoms, or cycloalkyl having 3-7 carbon atoms, where each alkyl may be optionally substituted with --OR.sub.4, or --NR.sub.5 R.sub.6 ;R.sub.2 and R.sub.3 are the same or different and representhydrogen, lower alkyl optionally mono- or disubstituted with alkoxy, aryl, halogen, or mono- or di-lower alkyl;aryl or aryl(C.sub.1 -C.sub.6)alkyl where each aryl is optionally substituted with up to three groups selected from halogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, or mono- or di (C.sub.1 -C6)alkylamino;cycloalkyl having 3-7 carbon atoms optionally mono or disubstituted with halogen, alkoxy, or mono- or di- lower alkyl; orSO.sub.2 R.sub.8,R.sub.4 is as defined for R.sub.1 ;R.sub.1 and R.sub.6 carry the same definitions as R.sub.2 and R.sub.3, respectively;R.sub.7 is hydrogen, lower alkyl having 1-6 carbon atoms, or cycloalkyl having 3-7 carbon atoms; andR.sub.8 is lower alkyl having 1-6 carbon atoms, cycloalkyl having 3-7 carbon atoms, or optionally substituted phenyl.