Patent ID: 8623894
Filing Date: 2014-01-07
Classification: A61K,A61P,C07D

Abstract:
1. A method for treating a CFTR mediated disease in a mammal comprising administering a solid form of a compound selected from Compound 1.2-methylbutyric acid, Compound 1.propylene glycol, Compound 1.PEG 400.KOAc, Compound 1.lactic acid, Compound 1.isobutyric acid, Compound 1.propionic acid, Compound 1.2-propanol, Compound 1.besylate, and Compound 1.besylate.H 2 O, wherein said disease is selected from cystic fibrosis, hereditary emphysema, COPD, and dry-eye disease, and Compound 1 is N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide.