Patent ID: 6395766
Filing Date: 2002-05-28
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: where A is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, arylC1-6alkyl, or aryl wherein the aryl group is optionally substituted by halogen, C1-6alkyl, CF3, CN, NO2 or NH2, NR1R10, S(O)pR1, heteroarylC1-6alkyl or heteroaryl where heteroaryl is a 5- or 6-membered heteroaromatic ring as defined for B below:B is phenyl or a 5-membered ring having one or two unsaturations containing 1, 2, 3 or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N, a 6-membered heteroaromatic ring containing 1, 2, 3 or 4 nitrogen atoms, each of which rings is optionally substituted by one or more substituents independently chosen from: cyano; C1-6alkyl; C1-6haloalkyl; halogen; S(O)rR4; COR5; aryl; arylC1-6alkyl; or a 5-membered ring substituent having one or two unsaturations containing 1, 2, 3 or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N; wherein the aryl ring substituent or 5-membered ring substituent is optionally substituted by one, two or three further substituents independently chosen from halogen, CF3, OCH3, nitro and cyano; and when a nitrogen ring atom is present it is optionally substituted by oxygen; R1 is hydrogen; C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl or C3-6cycloalkenyl each of which is optionally substituted by amino, C1-6alkylamino, di(C1-6alkyl)amino, C1-6alkoxy, C1-6alkylaminocarbonyl, one two or three hydroxy groups, one, two or three halogen atoms or a four, five or six-membered saturated heterocyclic ring containing a nitrogen atom and optionally either an oxygen atom or a further nitrogen atom which ring is optionally substituted by C1-4alkyl on the further nitrogen atom; aryl, arylC1-6alkyl, arylC2-6alkenyl or arylC2-6alkynyl optionally substituted on the aryl ring by halogen, nitro, cyano, C1-6alkylcarbonylamino, hydroxy or C1-6alkoxy; or a five-membered aromatic ring containing 1, 2, 3 or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N, or a six-membered aromatic ring containing 1, 2, 3 or 4 nitrogen atoms, which ring is optionally substituted by halogen, C1-6alkoxy, C1-6alkylthio, aryl, C1-6alkyl, C2-6alkenyl or C1-6alkynyl; R2 and R3 are independently hydrogen or C1-6alkyl or together with the carbon atom to which they are attached form a C3-8cycloalkyl group; R4 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aryl or CH2(CO)mNR8R9; R5 is NR6R7, C1-6alkyl or C1-6alkoxy; R6 is independently as defined for R4; R7 is aryl optionally substituted by halogen, nitro or cyano; R8 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl; arylC1-6alkyl, arylC2-6alkenyl or arylC2-6alkynyl optionally substituted on the aryl ring by halogen, nitro or cyano; thiophene or pyridine; R9 is C1-6alkyl; C2-6alkenyl; C2-6alkynyl; or phenyl optionally substituted by one, two or three substituents independently chosen from halogen, CF3, OCH3, nitro and cyano; R10 is hydrogen or C1-6alkyl; R14 is hydrogen or C1-6alkyl; m is zero or 1; p is zero, 1 or 2; q is 1 or 2; r is 0, 1 or 2; s is 0, 1 or 2; and t is 0, 1 or 2.