Patent ID: 6790860
Filing Date: 2004-09-14
Classification: A61P,C07D,Y02P

Abstract:
A compound selected from the group consisting of compounds of formula: whereinR1 is hydrogen, alkylcarbonyl, or arylcarbonyl; R2 is alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonyl, alkylcarbonylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, alkylsulfonyl, aryl, arylalkyl, arylalkoxyalkyl, aryl(alkoxycarbonyl)alkyl, arylcarbamoyl, diarylalkyl, aryl(carboxyalkyl)amide, arylamino, arylcarbonyl, arylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloallcylallcyl, heteroaryl, heteroarylalkyl, heterocyclylalkyl, or the group YR2 is heterocyclyl or R2 is a group of the formula: R3 is alkyl, alkylcycloalkyl, alkylcycloallcylalkyl, cycloalkyl, halogenalkyl, carboxyalkyl, aminoalkyl, dialkylaminoalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkinyl, aryl, arylalkyl, arylalkyl(alkoxycarbonyl)alkyl, arylcarbonylalkyl, aryloxyalkyl, arylalkenyl, aryl(alkoxycarbonyl)alkyl, heteroaryl, heteroarylalkyl, heterocyclyl or hetercycylalkyl R4 is alkyl or hydrogen; R7 is hydrogen, aryl, alkyl, arylalkyl, heterocyclylalkyl, arylamino, alkyl(arylalkyl)amino, alkoxycarbonylalkyl, carboxyalkyl, or alkylthioalkyl; R8 is hydroxy, alkyl, aryl, cyanoalkyl, alkoxy, arylalkyl, arylalkoxy, mono- or dialkylamino, arylamino, aryl(alkyl)amino, cyanoalkylamino, arylalkyl(alkyl)amino, heteroaryl, heteroarylalkyl, or heterocyclyl; X is C(O)Oâ€”; Y is â€”CH2, â€”Oâ€”, or â€”Sâ€”; and pharmaceutically acceptable esters, and pharmaceutically acceptable salts thereof.