Patent ID: 6214832
Filing Date: 2001-04-10
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR49##wherein Q is ##STR50##R.sup.1 is selected from unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, CF.sub.3, cyano, nitro, N(R.sup.7).sub.2, NR.sup.7 COR.sup.19, NR.sup.7 CON(R.sup.19).sub.2, NR.sup.7 SO.sub.2 R.sup.19, NR.sup.7 SO.sub.2 N(R.sup.19).sub.2, OR.sup.6, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.7).sub.2, or C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl wherein the substituents on the pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl are independently selected from CF.sub.3, cyano, nitro, amino, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.7).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, phenyl, OR.sup.6, halogen, C.sub.1-4 alkyl or C.sub.3-8 cycloalkyl;E, G, L and M are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.6, (CH.sub.2).sub.0-4 N(R.sup.7).sub.2, (CH.sub.2).sub.0-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.7).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.7, or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2 ;J is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.6, (CH.sub.2).sub.1-4 N(R.sup.7).sub.2, (CH.sub.2).sub.1-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.04 CON(R.sup.7).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.7, or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2 ;R.sup.2 is independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.4-8 cycloalkyl, (CH.sub.2).sub.04 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.7).sub.2, (CH.sub.2).sub.0-4 COR.sup.7, (CH.sub.2).sub.2-4 OR.sup.6, (CH.sub.2) 1-4CF.sub.3, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2 or (CH.sub.2).sub.1-4 CN;R.sup.3, R.sup.8, R.sup.14, R.sup.15 and R.sup.16 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.4 is selected from hydrogen, (CH.sub.2).sub.0-4 COR.sup.6, (CH.sub.2).sub.0-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.7).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2 ;R.sup.5 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.6 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.7 and R.sup.19 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.4-8 cycloalkyl or (CH.sub.2).sub.1-4 CF.sub.3 ;R.sup.11 and R.sup.12 are each independently selected from hydrogen, C.sub.1-8 alkyl or C.sub.3-8 cycloalkyl;R.sup.13 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.6, OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;W is O or NR.sup.11 ;R.sup.26 is selected from hydrogen or OR.sup.28 ;R.sup.28 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;X is selected from halogen, cyano, nitro, C.sub.1-8 alkyl C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3m and p are each integers from zero to two, wherein the sum m+p=2;n and o are each integers from zero to two, wherein the sum n+o=2;q is an integer of from zero to three, provided that when q is zero, R.sup.26 is hydrogen; ands is an integer of from zero to four;or a pharmaceutically acceptable salt thereof.