Patent ID: 6316494
Filing Date: 2001-11-13
Classification: C07D,Y10S

Abstract:
A compound of the formula I in which substituents R.sup.2 and R.sup.3 are arranged in cis-configuration: ##STR35##wherein:R.sup.2 is phenyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy and phenyl;R.sup.3 is:(a) phenyl substituted with --X--(CH.sub.2).sub.n --Y, wherein:X is a valency bond, O or S,n is an integer in the range of 1 to 12,Y is H, halogen, OH, OR.sup.4, NHCOR.sup.4, NHSO.sub.2 R.sup.4, CONHR.sup.4, CONR.sub.2.sup.4, COOH, COOR.sup.4, SO.sub.2 R.sup.4, SOR.sup.4, SONHR.sup.4, SONR.sub.2, a C.sub.3 -C.sub.7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group consisting of H, OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl and C.sub.1 -C.sub.6 -alkoxy; or(b) --(CH.sub.2).sub.n --V, wherein n is as defined above and V is H, OH, OR.sup.4, NHR.sup.4, NR.sub.2.sup.4, NHCOR.sup.4, NHSC.sub.2 R.sup.4, CONHR.sup.4, CONR.sub.2.sup.4, COOH, COOR.sup.4, SO.sub.2 R.sup.4, SOR.sup.4, SONHR.sup.4, SONR.sub.2.sup.4, a C.sub.3 -C.sub.7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group consisting of H, OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl and C.sub.1 -C.sub.6 -alkoxy; or(c) phenyl fused to a C.sub.3 -C.sub.7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group consisting of H, OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl and C.sub.1 -C.sub.6 -alkoxy; andR.sup.4 is C.sub.1 -C.sub.6 -alkyl;and optical and geometrical isomers, and pharmaceutically acceptable salts thereof.