Patent ID: 6716852
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:n represents an integer wherein 0&lE;n&lE;3, m represents an integer wherein 0&lE;m&lE;6, R3 and R4 together form, with the two carbon atoms carrying them, phenyl which may be unsubstituted or substituted by 1 to 3 identical or different groups selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, alkylthio, mercapto, cyano, nitro, amino, alkylamino, dialkylamino, polyhaloalkyl, azido, carboxy, alkoxycarbonyl, amido, carbamoyl, formyl, acyl, aryl, heteroaryl, and halogen, B represents heteroaryl, R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, acyl, aryl, arylalkyl, or aroyl, R1 represents hydrogen, acyl, aroyl, cycloalkylcarbonyl, or a group of formula (II): â€ƒwherein m, n, R2, R3, R4 and B are as defined hereinbefore, it being understood that: â€œalkylâ€  is a linear or branched, 1 to 6 carbon alkyl group, â€œalkenylâ€  is a 2 to 6 carbon alkyl group with one or more double bonds, â€œalkynylâ€  is a 2 to 6 carbon alkynyl group with one or more triple bonds, â€œcycloalkylâ€  is a 3 to 8 carbon cyclic alkyl group, â€œacylâ€  is a group RCO wherein R represents alkyl as defined hereinbefore, it being possible for the groups â€œalkylâ€ , â€œalkenylâ€  and â€œalkynylâ€  to be substituted by one or more identical or different groups selected from hydroxy, alkoxy, polyhaloalkyl, amino, and halogen, and it being possible for the groups â€œcycloalkylâ€  and â€œcycloalkylalkylâ€  to be substituted on the cyclic moiety by one or more identical or different groups selected from hydroxy, alkoxy, polyhaloalkyl, amino, and halogen, â€œarylâ€  may be phenyl or naphthyl, unsubstituted or substituted by one or more identical or different groups selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, alkylthio, mercapto, cyano, nitro, amino, alkylamino, dialkylamino, polyhaloalkyl, azido, carboxy, alkoxycarbonyl, amido, carbamoyl, formyl, acyl, and halogen, â€œheteroarylâ€  may be any mono- or poly-cyclic aromatic group containing 1 to 3 hetero atoms selected from oxygen, sulphur and nitrogen, the aromatic groups being unsubstituted or substituted by one or more identical or different groups selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, alkylthio, mercapto, cyano, nitro, amino, alkylamino, dialkylamino, polyhaloalkyl, azido, carboxy, alkoxycarbonyl, amido, carbamoyl, formyl, acyl, and halogen, it being possible for the polycyclic groups also to be partially or completely hydrogenated on one of the rings, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.