Patent ID: 8633211
Filing Date: 2014-01-21
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Q is selected from CH is selected from C 6 -C 15 -aromatic carbocyclic group, a C 5 -C 15 -carbocyclic group, and a 4- to 15-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur; R R R C C C C C R R R R R C a 4- to 15-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, and C R m and n are independently selected from an integer of 0, 1 and 2; and t is an integer selected from 1 and 2; wherein said C 6 -C 15 -aromatic carbocyclic group, C 7 -C 15 -aralkyl, C 3 -C 15 -carbocyclic group and 4- to 15-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, unless otherwise stated, are each optionally substituted by C 7 -C 15 -aralkyl, C 1 -C 8 -alkyl, CN, C 1 -C 8 -alkylsulfonyl, C 1 -C 8 -haloalkylsulfonyl, halogen, C 1 -C 8 -alkoxy, OH, C 1 -C 8 -alkylcarbonyl, —C(O)—C 6 -C 15 -aromatic carbocyclic group, —C(O)—C 3 -C 15 -carbocyclic group, —C(O)-4- to 15-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, C 1 -C 8 -cyanoalkyl, C 1 -C 8 -cyanoalkoxy, C 1 -C 8 -haloalkyl, C 1 -C 8 -haloalkoxy, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, C 1 -C 8 -alkylamino, di(C 1 -C 8 -alkyl)amino, COOH, C 1 -C 8 -alkoxycarbonyl, 4- to 15-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur optionally substituted by C 7 -C 15 -aralkyl, C 1 -C 8 -alkyl, CN, C 1 -C 8 -alkylsulfonyl, C 1 -C 8 -haloalkylsulfonyl, halogen, C 1 -C 8 -alkoxy, OH, C 1 -C 8 -alkylcarbonyl, C 1 -C 8 -Cyanoalkyl, C 1 -C 8 -Cyanoalkoxy, C 1 -C 8 -haloalkyl, C 1 -C 8 -haloalkoxy, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, C 1 -C 8 -alkylamino, di(C 1 -C 8 -alkyl)amino COOH, or C 1 -C 8 -alkoxycarbony, a C 6 -C 15 -aromatic carbocyclic group optionally substituted by C 7 -C 15 -aralkyl, C 1 -C 8 -alkyl, CN, halogen, C 1 -C 8 -alkoxy, OH, C 1 -C 8 -alkylcarbonyl, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, C 1 -C 8 -alkylamino, di(C 1 -C 8 -alkyl)amino, COOH, CF 3 , or C 1 -C 8 -alkoxycarbonyl or a C 3 -C 15 -carbocyclic group optionally substituted by C 7 -C 15 -aralkyl, C 1 -C 8 -alkyl, CN, halogen, C 1 -C 8 -alkoxy, OH, C 1 -C 8 -alkylcarbonyl, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, C 1 -C 8 -alkylamino, di(C 1 -C 8 -alkyl)amino, COOH, CF 3 , or C 1 -C 8 -alkoxycarbonyl; with the proviso that said compound of formula (I) is not 3-{1-[(5-chloro-2-methoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-N-cyclopentyl-propionamide, N-(5-chloro-2,4-dimethoxy-phenyl)-2-[2,4-dioxo-3 {[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl}-phenyl)-3,4-dihydro-2H-quinazolin-1-yl]acetamide, 4-{6-chloro-1-[2-(3-chloro-4-ethoxy-phenyl)-2-oxoethyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-N-cyclopentyl-butyramide, 2-{1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-N-furan-2-ylmethyl-acetamide, 4-(2-{2,4-dioxo-3-[4-(phenethylcarbamoyl-methyl)-phenyl]-3,4-dihydro-2H-quinazolin-1-yl}-acetylamino)-benzoic acid ethyl ester, N-(3,5-dichloro-phenyl)-2-{2,4-dioxo-3-[4-(phenethylcarbamoyl-methyl)-phenyl]-3,4-dihydro-2H-quinazolin-1-yl}-acetamide, 2-{1-[(4-chloro-2-methoxy-5-methyl-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-N-cyclopentyl-acetamide, 2-{1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-N-phenethyl-acetamide and 1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-3-phenyl-1,3,4,5,6,8-hexahydro-2H-pyrido[4′,3′:4,5]thieno[2,d]pyrimidine-7-carboxylic acid ethyl ester.