Patent ID: 7674825
Filing Date: 2010-03-09
Classification: A61P,C07C,C07D

Abstract:
1. A method for treating a cardiovascular disease in a subject, the method comprising administering to the subject an effective amount of a compound capable of stimulating soluble guanylate cyclase independently of the heme group in the enzyme, wherein the compound is represented by the formula: wherein B represents aryl having from 6 to 10 carbon atoms or an aromatic heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O; W is CH X is (CH U is CH A is phenyl; R R R r is 1; V is absent or represents O, NH or S; Q is absent or represents straight-chain or branched alkylene, straight-chain or branched alkenediyl having in each case up to 15 carbon atoms, which may contain one or more groups selected from O, S(O) Y represents hydrogen, NR or a salt thereof.