Patent ID: 9063123
Filing Date: 2015-06-23
Classification: A01K,C07K,C12N,G01N

Abstract:
1. A transgenic mouse whose genome comprises a nucleotide sequence encoding human Toll-like receptor 8 (TLR8 ), wherein said human TLR8 is expressed in the transgenic mouse, and wherein at least one inflammatory cytokine selected from the group consisting of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-12 p40 (IL-12B), chemokine cc motif ligand 2 (CCL-2) and interferon-gamma-inducible protein 10 (IP10) is present in sera from the transgenic mouse at an elevated level as compared to a control, non-transgenic mouse.