Patent ID: 6849630
Filing Date: 2005-02-01
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I): and pharmaceutically acceptable salts thereof, wherein: A and B are independently selected from —CH wherein E is phenyl, furyl, thienyl, pyridyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, triazolyl, oxadiazolyl, pyrimidinyl, pyrazinyl, indolyl, isoindolyl, benzimidazolyl, benzothiophenyl, quinolinyl, isoquinolinyl, and benzothiazolyl; wherein 1 to 4 hydrogen atoms in B are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO wherein each of R each n is independently 0 to 4; each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C K wherein K J and K, taken together with the two nitrogens that they are attached to, form a 6 membered piperazine G, when present, is —S(O) Y is oxygen, or N(R wherein R D is (C D is an aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 2 of the CH x=0 or 1; and X=O or two hydrogens attached to ring carbon.