Patent ID: 7585842
Filing Date: 2009-09-08
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polypeptide comprising the primary structure of the wild-type KD 1 domain of human tissue factor pathway inhibitor-2 (TFPI-2) of SEQ ID NO: 2 or a biologically active subunit thereof, wherein the biological activity is serine protease inhibition, with the proviso that said polypeptide or a biologically active subunit thereof includes a lysine instead of arginine at position 24 and at least one of the following additional changes with respect to the wild-type KD 1 primary structure selected from the group consisting of: an arginine instead of a leucine at position 26; a threonine instead of a tyrosine at position 20; a glutamate or a tyrosine instead of an aspartate at position 19; and a glutamate or a lysine instead of a tyro sine at position 55; wherein the amino acid numbering is as defined for the wild-type KD 1 amino acid sequence.