Patent ID: 7338788
Filing Date: 2008-03-04
Classification: A61K,B82Y

Abstract:
1. An isolated nucleic acid comprising a nucleotide sequence encoding an interferon β polypeptide variant exhibiting an interferon β activity, the variant comprising a variant sequence which differs from the wild-type human interferon β sequence SEQ ID NO:2 in no more than 8 amino acid residues and which comprises at least one introduced N-glycosylation site selected from the group consisting of S2N+N4T/S, L9N+R11T/S, R11N, S12N+N14T/S, F15N+C16S/T, Q16N+Q18T/S, K19N+L21T/S, Q23N+H25T/S, G26N+L28T/S, R27N+E29T/S, L28N+Y30T/S, D39T/S, K45N+L47T/S, Q46N+Q48T/S, Q48N+F50T/S, Q49N+Q51T/S, Q51N+E53T/S, R71N+D73T/S, Q72N, D73N, S75N, S76N+G78T/S, L88T/S, Y92T/S, H93N+I95T/S, L98T/S, E103N+K105T/S, E104N+L106T/S, E107N+E109T/S, K108N+D110T/S, D110N, F111N+R113T/S, and L116N relative to SEQ ID NO:2.