Patent ID: 6667304
Filing Date: 2003-12-23
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:the symbol â€ƒrepresents R1 represents halogen or â€”R, â€”OR, â€”S(O)nR, â€”NRRâ€², â€ƒor â€”SO2NRRâ€² wherein n is 0, 1 or 2, Z represents sulphur or oxygen, and R, Râ€² and Râ€³, which may be identical or different, represent hydrogen or unsubstituted or substituted linear or branched (C1-C6)alkyl, unsubstituted or substituted linear or branched (C2-C6)alkenyl, unsubstituted or substituted linear or branched (C2-C6)alkynyl, unsubstituted or substituted (C3-C8)cyclo-alkyl, unsubstituted or substituted (C3-C8)cycloalkyl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, aryl, aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, heteroaryl or heteroaryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, â€ƒit also being possible for (R and Râ€²) and (Râ€² and Râ€³) to form together with the nitrogen atom carrying them morpholinyl, piperidinyl, piperazinyl or pyrrolidinyl, those groups being unsubstituted or substituted, G1 represents an alkylene chain having from 1 to 4 carbon atoms, optionally substituted by R, OR, COR or COOR wherein R is as defined hereinbefore, or G1 represents an alkylene chain having from 1 to 4 carbon atoms in which one of the CH2 groups can be replaced by a cycloalkylene (C3-C8), A represents â€ƒwherein R, Râ€², Râ€³ and Z are as defined hereinbefore, B forms with the nitrogen atom and the carbon atom to which it is attached a ring having from 5 to 8 ring members, which may contain one or more unsaturated bonds, R2 and R3, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy or hydroxy, or R2 and R3 together form oxo, R4 and R5 represent hydrogen, the symbol  means that the bond may be single or double, with the proviso that the valence of the atoms is respected, it being understood that: the term â€œsubstitutedâ€  applied to the terms â€œalkylâ€ , â€œalkenylâ€ , â€œalkynylâ€ , â€œcycloalkylâ€ , â€œmorpholinylâ€ , â€œpiperidinylâ€ , â€œpiperazinylâ€  and â€œpyrrolidinylâ€  means that those groups may be substituted by one or more groups selected from hydroxy, oxo, alkoxy, alkyl, polyhaloalkyl, and halogen, the term â€œsubstitutedâ€  applied to the term â€œcycloalkylalkylâ€  means that the cyclic moiety of the group is substituted by one or more groups selected from hydroxy, oxo, alkoxy, alkyl, polyhaloalkyl, and halogen, â€œarylâ€  is understood to mean phenyl, naphthyl or biphenyl, those groups being unsubstituted or substituted by one or more identical or different groups selected from hydroxy, alkoxy, alkyl, amino, alkylamino, dialkylamino, nitro, cyano, polyhaloalkyl, formyl, carboxy, alkoxycarbonyl, amido, and halogen, â€œheteroarylâ€  is understood to mean furyl, pyrrolyl, imidazolyl, pyridyl, thienyl, pyrazinyl, benzothienyl, benzofuranyl, indolyl, benzimidazolyl, quinolyl or quinazolinyl, those groups being unsubstituted or substituted by one or more identical or different groups selected from hydroxy, alkoxy, alkyl, amino, alkylamino, dialkylamino, nitro, cyano, polyhaloalkyl, formyl, carboxy, amido, and halogen, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.