Patent ID: 7199113
Filing Date: 2007-04-03
Classification: A61K,A61P,C07F

Abstract:
1. A method of blocking or inhibiting tissue factor-dependent activation of factor X and/or factor IX, comprising contacting tissue factor with a TF blocking compound to thereby inhibit formation of a functional complex of factor X or factor IX with tissue factor or TF/VIIa, wherein the TF blocking compound is of the following formula I: wherein, Ar is optionally substituted carbocyclic aryl or optionally substituted heteroaryl; Het is optionally substituted N, O, S, S(O) or S(O each X, each Y, each X′, each Y′ and each Z are each independently hydrogen; halogen; hydroxyl; sulfhydryl; amino; optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted alkoxy; optionally substituted alkylthio; optionally substituted alkylsulfinyl; optionally substituted alkylsulfonyl; or optionally substituted alkylamino; m and n each is independently an integer of from 0 to 4; p is 1 or 2; and pharmaceutically acceptable salts thereof.