Patent ID: 7122634
Filing Date: 2006-10-17
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A human factor VIII modified to comprise at least one amino acid substitution in the C2 domain wherein the substitution is limited to at least one position selected from the group consisting of 2181, 2182, 2195, 2196, 2197, 2207, 2216, 2222, 2224, 2225, 2226, 2228, 2234, 2238, and 2243 according to SEQ ID NO: 2, said substitution being insertion of an immunoreactivity-reducing amino acid for the naturally-occurring amino acid, wherein the immunoreactivity-reducing amino acid is selected from the group consisting of alanine, methionine, leucine, serine and glycine, said factor VIII having procoagulant activity.