Patent ID: 6034246
Filing Date: 2000-03-07
Classification: A61P,C07D

Abstract:
A pharmaceutical composition suitable for administration to a mammal and comprising an effective amount of a benzazole compound of structural formula I below, or a pharmaceutically acceptable salt thereof, ##STR8## wherein: X is S or O,R.sup.1 and R.sup.3 are each independently hydrogen, alkyl, hydroxyl, alkoxy or aralkoxy,R.sup.2 is selected from hydrogen, NO.sub.2, NH.sub.2, halogen, alkyl, CN, and a substituted alkyl oxysulphonyl group;R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, benzoyl or an acyl group ##STR9## where Y is O or S, and R.sup.8 is alkyl, or halogenated alkyl, or SO.sub.3.sup.- M.sup.+where M.sup.+ is a monovalent cation or cationic group; andR.sup.7 is hydrogen, 5'-halogen or 5'-alkyl, together with a pharmaceutically acceptable carrier therefor, subject to the following provisos:a) when R.sup.5 and R.sup.6 are each hydrogen or alkyl, R.sup.2 is not hydrogen but is a 3'-substituent in the phenyl group other than a 3'-substituted alkyl oxysulphonyl group;b) R.sup.7 is limited to being hydrogen unless R.sup.2 is a 3'-substituent in the phenyl group;c) if R.sup.2 is NO.sub.2 it is a 3'-substituent in the phenyl group;d) alkyl groups are each composed of less than 6 carbon atoms;e) the compound is not 2-(4'-amino-3'-iodophenyl)benzothiazole or a salt thereof other than a sulphamate salt;f) R.sup.8 is not alkyl or cycloalkyl when R.sup.2 is hydrogen, said pharmaceutical composition being in cachet, tablet, capsule, lozenge suppository, syrup or elixir form, or being in the form of a sterile liquid formulation, a paste or electuary, a powder or granules or an ointment or cream.