Patent ID: 6103232
Filing Date: 2000-08-15
Classification: A61K,A61P,C07K,C12N,G01N,Y10S

Abstract:
A method for inducing neurite outgrowth in the central nervous system of a patient with damage to the central nervous system comprising administering to the patient a therapeutically effective amount of an antibody or fragment thereof, which antibody or fragment thereof antagonizes the function of a neurite growth inhibitory factor consisting of a protein characterized by the following properties:(a) a nonpermissive substrate property as detected by the ability to inhibit neurite outgrowth and fibroblast spreading in vitro;(b) capable of being isolated from central nervous system myelin of a higher vertebrate; and(c) an approximate molecular weight of 35,000 daltons or of 250,000 daltons as determined by polyacrylamide gel electrophoresis.