Patent ID: 6310061
Filing Date: 2001-10-30
Classification: A61P,C07D,Y02P

Abstract:
A compound of the following formula: ##STR34##and the salts thereof, whereinA is hydrogen, halo, hydroxy, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo C.sub.1 -C.sub.6 alkoxy, oxo, OY wherein Y is a hydroxy protecting group, or absent;the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent;Ar.sup.1 is phenyl optionally substituted by one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy, CF.sub.3, carboxy-C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alkoxy-carbonyl-C.sub.1 -C.sub.4 alkoxy;Ar.sup.2 is pyrimidyl, optionally substituted by one or more substituents selected from halo, hydroxy, amino, nitro, carboxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylamino, di C.sub.1 -C.sub.4 alkylamino, halo C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkythio and sulfonyl methyl;R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or OY wherein Y is a hydroxy protecting group; andR.sup.2 and R.sup.3 are independently selected from hydrogen, hydroxy, C.sub.1 -C.sub.7 alkyl optionally substituted by one or more hydroxy or halo, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.7 alkoxy, phenyl optionally substituted by halo, phenyl C.sub.1 -C.sub.7 alkyl, halo substituted phenyl C.sub.1 -C.sub.7 alkyl, and (CH.sub.2)nX-R.sup.4 wherein n is one or two; X is O, NH or S and R.sup.4 is C.sub.1 -C.sub.3 alkyl, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a pyrrolidine, piperidine or morpholine ring, optionally substituted by C.sub.1 -C.sub.3 alkyl or halo.