Patent ID: 7526387
Filing Date: 2009-04-28
Classification: C12Q,G01N,G16B

Abstract:
1. A method for determining the likelihood of breast cancer recurrence or response to hormonal therapy in a mammalian subject comprising: (a) measuring the expression levels of the RNA transcripts of GRB7, HER2, EstR1, PR, Bcl2, CEGP1, SURV, Ki.67, MYBL2, CCNB1, STK15, CTSL2, and STMY3, or their expression products in a biological sample containing tumor cells obtained from said subject; (b) creating the following gene subsets comprising: (c) calculating a recurrence score (RS) for said subject by weighting the measured expression levels of each of the gene subsets by contribution to breast cancer recurrence; (d) using said RS to determine the likelihood of breast cancer recurrence or response to therapy; and (e) creating a report summarizing the result of said determination.