Patent ID: 6432993
Filing Date: 2002-08-13
Classification: A61P,C07D

Abstract:
A substituted fused heterocyclic compound represented by the following formula (I): wherein:R1 represents a group selected from the following formulae (II) and (III): â€ƒin which: R4 is selected from the group consisting of phenyl groups which are substituted with 1 to 5 substituents selected from Substituents &agr; defined below and pyridyl groups which may be substituted with 1 to 4 substituents selected from Substituents &agr; defined below; R5 is selected from the group consisting of hydrogen atoms and Substituents &agr; defined below; R6 is selected from the group consisting of hydrogen atoms, C1-6 alkyl groups, C6-10 aryl groups which may be substituted with 1 to 3 substituents selected from Substituents &bgr; defined below and C7-16 aralkyl groups which may be substituted with 1 to 3 substituents selected from Substituents &bgr; defined below; D represents is selected from the group consisting of oxygen and sulfur atoms; and E is selected from the group consisting of CH groups and nitrogen atoms; R2 is selected from the group consisting of hydrogen atoms and Substituents &agr; defined below; R3 represents a group selected from the following formulae (IV-1) to (IV-5) or a tautomer thereof in the case of (IV-2), (IV-3) or (IV4): A represents a C1-6 alkylene group; B is selected from the group consisting of oxygen and sulfur atoms; Substituents &agr; are selected from the group consisting of halogen atoms, hydroxyl groups, C1-6 alkyl groups, halogeno(C1-6 alkyl) groups, C1-6 alkoxy groups, C1-6 alkylthio groups, amino groups which may be substituted with substituents selected from Substituents &ggr; defined below, C3-10 cycloalkyl, C6-10 aryl, C7-16 aralkyl, C6-10 aryloxy, C7-16 aralkyloxy and C6-10 arylthio groups each of which may be substituted with 1 to 3 substituents selected from Substituents &bgr; defined below, C1-7 aliphatic acyloxy groups, 4- to 7-membered saturated nitrogen-containing heterocyclic groups, 5- or 6-membered aromatic nitrogen-containing heterocyclic groups, nitro groups, and cyano groups; Substituents &bgr; are selected from the group consisting of halogen atoms, hydroxyl groups, C1-6 alkyl groups, halogeno(C1-6 alkyl) groups, C1-6 alkoxy groups, amino groups which may be substituted with substituents selected from Substituents &ggr; defined below, C6-10 aryl groups and nitro groups; and Substituents &ggr; are selected from the group consisting of C1-10 alkyl groups, C6-10 aryl and C7-16 aralkyl groups (each of which may have 1 to 3 substituents selected from the group consisting of halogen atoms and hydroxyl, C1-6 alkyl, halogeno(C1-6 alkyl), C1-6 alkoxy and C1-6 alkylthio groups) and acyl groups (said acyl group is selected from the group consisting of C1-7 aliphatic acyl groups and C7-11 aromatic acyl, C8-12 aromatic aliphatic acyl, C4-11 cycloalkylcarbonyl and 5- or 6-membered aromatic nitrogen-containing heterocyclic carbonyl groups, each of which may have 1 to 3 substituents selected from the group consisting of halogen atoms and hydroxyl, C1-6 alkyl, halogeno(C1-6 alkyl), C1-6 alkoxy and C1-6 alkylthio groups); with the proviso that 5-{4-[5-(3,5-di-t-butyl-4-hydroxyphenylthio)-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy]benzyl}thiazolidine-2,4-dione is excluded; or a pharmacologically acceptable salt or prodrug of said compound of the formula (I).