Patent ID: 8039261
Filing Date: 2011-10-18
Classification: A01K,A61K,A61P,C12N

Abstract:
1. A method of downregulating angiogenesis in a tissue of a subject, the method comprising administering directly or intravenously to the subject a nucleic acid construct including: (a) a first polynucleotide region encoding a chimeric polypeptide including: i) the extracellular region of the type I tumor necrosis factor receptor (TNFR1); and ii) the trans-membrane and intracellular regions of the Fas receptor; and (b) a second polynucleotide region comprising: i) a pre-proendothelin 1 (PPE-1) promoter; ii) and endothelial regulatory element comprising a nucleotide sequence as set forth in SEQ ID NO: 8 and at least one copy of a nucleotide sequence as set forth in SEQ ID NO: 6, thereby down-regulating angiogenesis in the tissue, wherein said subject is being treated with a chemotherapeutic agent.