Patent ID: 7238675
Filing Date: 2007-07-03
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method of treating an infection in a human or mammalian animal subject, caused by Escherichia coli, Salmonella thyphimurium, Pseudomonas aeruginosa, Vibrio cholera, Neisseria gonorrhoea, Helicobacter pylori, Treponema palladium, Chlamydia trachomatis, Bartonella henselae, Hemophilis influenza or Shigella dysenterae, comprising administering to the subject, in a pharmaceutically effective amount, a substantially uncharged morpholino antisense oligomer containing from 10 to 40 nucleotide subunits, each of said subunits comprising a morpholino ring supporting a base-pairing moiety effective to bind by Watson-Crick base pairing to a respective nucleotide base, said base-pairing moieties including a targeting nucleic acid sequence of at least 10 nucleotides in length contained in SEQ ID NO:30, which is able to stably hybridize to a bacterial 16S rRNA from the infecting bacterium, wherein adjacent subunits are linked together by phosphorous-containing linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5′ exocyclic carbon of an adjacent subunit, and the ratio of uncharged linkages to charged linkages in the oligomer is at least 4:1.