Patent ID: 8501396
Filing Date: 2013-08-06
Classification: A61B,A61F,A61K,C12N,Y10T

Abstract:
1. A genetically modified dermal micro-organ expressing at least one recombinant gene product, wherein said dermal micro-organ is an explant of living tissue consisting essentially of a plurality of dermal components and lacking a complete epidermal layer and maintaining the micro-architecture and three-dimensional structure of the dermal tissue from which they are obtained, having dimensions selected so as to enable passive diffusion of adequate nutrients and gases to cells of said dermal micro-organ and diffusion of cellular waste out of said cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in said dermal micro-organ, wherein at least some of said cells of said dermal micro-organ express at least a portion of said at least one recombinant gene product, and wherein said at least one recombinant gene product is selected from growth hormone, interferon β, insulin, PDGF-BB, interleukin 1 receptor agonist (IL-1Ra), peptide YY3-36, interleukin 10 (IL-10), and G-CSF.