Patent ID: 9125954
Filing Date: 2015-09-08
Classification: A61K,C07B,C07C,C07D

Abstract:
1. A method for the synthesis of a compound of Formula I: or a salt or solvate thereof, wherein: R n is an integer of 1-6; wherein said method comprises: (i) providing [ (ii) eluting the ion-exchange cartridge of step (i) with an aqueous solution comprising a first aliquot of an eluent, wherein said eluent comprises a cationic counterion in a suitable solvent, to obtain a [ (iii) reacting a compound of Formula II: (iv) deprotonating a compound of Formula IV: (v) reacting the compound of Formula III obtained in step (iii) with said deprotonated compound obtained in step (iv), or a protected version thereof, in a second solvent to obtain said compound of Formula I, or a protected version thereof, wherein said second solvent is an alkanol or an aqueous alkanol; (vi) removing any protecting groups.