Patent ID: 8927603
Filing Date: 2015-01-06
Classification: A61K,A61L

Abstract:
1. A method for preparing a sterile, liquid monomeric cyanoacrylate adhesive composition in a sealed container using X-ray radiation, wherein the method comprises: (a) stabilizing a liquid monomeric cyanoacrylate adhesive composition using a combination of a free radical stabilizer and an anionic stabilizer to produce a stabilized liquid monomeric cyanoacrylate adhesive composition; (b) placing the stabilized liquid monomeric cyanoacrylate adhesive composition in a container and sealing said container; and (c) irradiating the stabilized liquid monomeric cyanoacrylate adhesive composition in said sealed container with X-ray radiation at a dose of from about 5 kGy to about 40 kGy, thereby producing a sterilized, stabilized liquid monomeric cyanoacrylate adhesive composition, wherein the sterilized, stabilized liquid monomeric cyanoacrylate adhesive composition exhibits no change in viscosity or a negligible change in viscosity after irradiation, and has a shelf life of at least two years at ambient temperature.