Patent ID: 7709476
Filing Date: 2010-05-04
Classification: A61K,A61P,C04B,C07D

Abstract:
1. A compound of the structure: or a pharmaceutically acceptable salt, crystal form, or hydrate, wherein: A is b) a heteroaryl ring selected from the group consisting of R R R R R R R R R n, p, g, r, and s are independently 0, 1, 2, 3, 4, 5 or 6, wherein said compounds are selected from the group consisting of 6-Methoxy-3-(methoxymethyl)-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-2-methyl-4-phenyl-3-[(2,2,2-trifluoroethoxy)methyl]isoquinolin-1(2H)-one, (±)-6-Methoxy-2-methyl-4-phenyl-3-[(tetrahydrofuran-3-yloxy)methyl]isoquinolin-1(2H)-one, 2-{2-[(6-Methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methoxy]ethyl}-1H-isoindole-1,3(2H)-dione, 6-Methoxy-2-methyl-3-[(2-morpholin-4-ylethoxy)methyl]-4-phenylisoquinolin-1(2H)-one, (±)-6-Methoxy-2-methyl-3-{[(1-methylpiperidin-3-yl)oxy]methyl}-4-phenylisoquinolin-1(2H)-one, 3-[(2-Aminoethoxy)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-2-methyl-4-phenyl-3-[(pyridin-4-ylmethoxy)methyl]isoquinolin-1(2H)-one, 6-Methoxy-2-methyl-3-{[2-(methylsulfonyl)ethoxy]methyl}-4-phenylisoquinolin-1(2H)-one, 3-(Hydroxymethyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-3-{[(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl) methoxy]methyl}-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-2-methyl-3-{[(1-oxidopyridin-3-yl)oxy]methyl}-4-phenylisoquinolin-1(2H)-one, (±)-6-Methoxy-2-methyl-3-[(oxiran-2-ylmethoxy)methyl]-4-phenylisoquinolin-1(2H)-one, 3-(tert-Butoxymethyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, (±)-3-[(2-Hydroxy-3-piperidin-1-ylpropoxy)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, (±)-3-[(2-Hydroxy-3-morpholin-4-ylpropoxy)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, (±)-3-{[3-(Dimethylamino)-2-hydroxypropoxy]methyl}-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-3-[(2-methoxyethoxy)methyl]-2-methyl-4-phenylisoquinolin-1(2H)-one, 6-Methoxy-3-{[2-(2-methoxyethoxy)ethoxy]methyl}-2-methyl-4-phenylisoquinolin-1(2H)-one, 3-{[(2-Hydroxyethyl)thio]methyl}-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, 3-{[(2-(Dimethylamino)ethyl)thio]methyl}-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, (±)-3-{[(2-Hydroxyethyl)sulfinyl]methyl}-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one, and 3-{[(2-Hydroxyethyl)sulfonyl]methyl}-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one.