Patent ID: 7045532
Filing Date: 2006-05-16
Classification: A61K,C07B,C07C,C07D,C07K

Abstract:
1. A method of treating an ACE-2 associated state in a subject, comprising administering to a subject in need of decreasing appetite, decreasing body fat, increasing muscle mass, or treating a body weight disorder, an effective amount of an ACE-2 inhibitor, wherein said ACE-2 inhibitor is of the formula (IV): wherein R R R R Q is a bond, O, S, CR G is a linking moiety; M is an anchor moiety; J is a bond, an alkyl, alkenyl, or alkynyl moiety; D is hydrogen, alkoxy, amine, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, optionally linked to G, M or Q to form a ring; t is 0 or 1; p is 0, 1, 2, 3, 4, or 5; q is 0, 1, 2, or 3, or an enantiomer, diastereomer, mixture of enantiomers, mixture of diastereomers or pharmaceutically acceptable salt thereof; and wherein said inhibitor is not a naturally occurring amino acid.