Patent ID: 6492501
Filing Date: 2002-12-10
Classification: C08F,G01N,Y10S

Abstract:
A membrane protein-vinyl polymer water-soluble complex, comprising a membrane protein and a vinyl polymer which is amphiphilic and has the following formula: whereinR1 is a group selected from a) COOâˆ’M+, wherein M+ is an alkali metal cation; b) COOR7 wherein R7 is selected from a sugar residue, Hâ€”(OCH2â€”CH2â€”)4-10, or (CH2)tâ€”NR10R11, wherein t is an integer from 1 to 5 and R10 and R11, are the same, or different, and are selected from hydrogen or (C1-C4)alkyl; c) N-pyrrolidonyl; d) phenyl sulfonate; or e) CONR8R9, wherein R8 and R9, are the same or different, and are selected from hydrogen atom, a sugar residue, Hâ€”(OCH2â€”CH2â€”)4-10, or a zwitterionic radical; R2 is a group selected from COOR12 or CONR13R14, wherein R12 is a linear or branched alkyl or alkenyl of 6 to 12 carbon atoms, and R13 and R14, are the same or different, and are selected from a linear or branched alkyl or alkenyl radical of 6 to 12 carbons or one of R13 or R14 is a hydrogen atom; R3 is a group selected from COOR15 or CONR16R17, wherein R15 is (C1-C5)alkyl, and R16 and R17 are (C1-C5)alkyl or one of R16 or R17 is a hydrogen atom; R4, R5 and R6, are the same or different, and are selected from a hydrogen atom or a methyl radical; x represents the percentage of y represents the percentage of â€ƒand z represent the percentage of wherein x is between 20-90%, y is between 10-80%, and z is between 0-60%; and the average molar mass is between 500 and 100,000.