Patent ID: 8828405
Filing Date: 2014-09-09
Classification: A61K,A61P,C07H,C12N

Abstract:
1. A composition for generating an immune response in a mammal, wherein said composition comprises vesicles formed of amphiphilic components, wherein said vesicles are associated with a nucleic acid and an assistor protein, wherein the nucleic acid operatively encodes an antigenic protein or portion thereof which shares at least one epitope with the assistor protein, wherein the vesicles have an average diameter in the range of 100-2000 nm, wherein the nucleic acid encoding the antigenic protein, and the assistor protein, are associated with the same vesicles; wherein the nucleic acid is entrapped in the intravesicular space of the vesicles and the assistor protein is displayed on the surface of the same vesicle, whereby the nucleic acid and assistor protein will be co-delivered by the vesicles to a cell.