Patent ID: 8859523
Filing Date: 2014-10-14
Classification: A61K,A61P,C07K

Abstract:
1. A method for locally administering an in-situ crosslinkable or crosslinked gel to a subject in need thereof, the method comprising: (a) reconstituting a first composition comprising a thiol-functionalized hyaluronic acid (HA) in a buffer to form a first reconstituted composition; reconstituting a second composition comprising a thiolated collagen or a thiolated gelatin of formula (I) where Y is a residue of collagen or gelatin, in a buffer to form a second reconstituted composition, mixing the first and second reconstituted compositions with a homobifunctional crosslinker comprising two electron-deficient vinyl groups under conditions effective to promote crosslinking of the resulting mixture, and (b) applying or injecting the mixture from (a) onto or into a body site of the subject, wherein crosslinking of the mixture either prior to or after applying or injecting on or within the body site is effective to convert the mixture into a crosslinked hydrogel.