Patent ID: 6660735
Filing Date: 2003-12-09
Classification: A61K,A61P,C07D

Abstract:
A compound of the Formula (I): wherein:X is â€”CHR5â€”, â€”CHR5-alkyl-, or â€”CHR5-alkenyl; R1 is selected from the group consisting of: R4â€”NR8â€”CR3â€”NR5-Z-R6-alkyl; R4â€”NR8â€”CR3â€”NR5-Z-R6alkenyl; R4â€”NR8â€”CR3â€”NR5-Z-R4-aryl; R4â€”NR8CR3â€”NR5-Z-R6heteroaryl; R4â€”NR8â€”CR3â€”NR5-Z-R6-heterocyclyl; R4â€”NR8â€”CR, â€”NR5R7; R4â€”NR8â€”CR3â€”NR9-Z-R6-alkyl; R4NR8CR3â€”NR9Zâ€”R6-alkenyl; R4â€”NR8â€”CR3â€”NR9-Z-R6-aryl; R4â€”NR8CR3â€”NR9-Z-R6-heteroaryl; and R4â€”NR8CR3â€”NR9-Z-R6heterocyclyl; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -alkyl-Y-alkyl; -alkyl-Y-alkenyl; -alkyl-Y-aryl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; N(R5)2; â€”COâ€”N(R5)2; â€”COâ€”C1-10 alkyl; â€”COâ€”Oâ€”C1-10 alkyl; â€”N3; -aryl; -heteroaryl; -heterocyclyl; â€”CO-aryl; and â€”CO-heteroaryl; R3 is &boxH;O or &boxH;S; R4 is alkyl or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; each R5 is independently H or C1-10 alkyl; R6 is a bond, alkyl, or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; R7 is H or C1-10 alkyl which may be interrupted by a hetero atom, or when R7 is C1-10 alkyl which may be interrupted by a hetero atom and R5 is C1-10 alkyl, R7 can join with R5 to form a morpholine ring; R8 is H, C1-10 alkyl, or arylalkyl; or when R4 is C1-10 alkyl and R8 is C1-10 alkyl R4 and R8 can join together to form a piperidine ring; R9 is C1-10 alkyl, Y is â€”Oâ€” or â€”S(O)0-2; Z is a band, â€”COâ€”, or â€”SO2â€”; n is 0; and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, hydroxy, halogen and trifluoromethyl; or a pharmaceutically acceptable salt thereof.