Patent ID: 7498406
Filing Date: 2009-03-03
Classification: A61P,C07F

Abstract:
1. A method for preparing a compound according to the Formula (I): Wherein: A is selected from the group consisting of glutathione, glucosamine, cysteinyiglycine, cysteic acid, aspartic acid, glutamic acid, lysine, and arginine, and wherein the sulfur atom of each sulfur containing compound may be optionally oxidized to form a sulfbxide or sulfone; L corresponds to (XBX′) n is an integer from X is selected from the group consisting of: NR—, S(O)—, —S(O)O—, —S(O) B is selected from C X′ is selected from NR—, —O—, —S—, —Se—, —S—S—, S(O)—, —OS(O)—, OS(O)O—, OS(O) or is absent; wherein E is O, S, Se, NR or N(R) 2 − ; and B′ is C each R is independently selected from hydrogen, C R′ is the same as R or two R′ may be taken together with the nitrogen atoms to which they are attached to form a 5 or 6-membered saturated or unsaturated heterocyclic ring; each R each R each R wherein for each instance that B and/or B′ is arylene, the substituents directly attached to the respective arylene rings (including arsenoxide), may be in a para, meta or ortho relationship, and wherein each alklene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene, heterocycloalkenylene, arylene, heteroarylene and acyl may be independently substituted with hydrogen, C wherein R, R 1 and R 5 are as defined above; and R each R each R R R″ is the same as R or two R″ taken together with the N atom to which they are attached may form a saturated, unsaturated or aromatic heterocyclic ring system; Q is selected from halogen and —OS(O) m is 1 to 5, Y comprises at least one arsenoxide; and p is an integer from 1 to 10; and wherein the sum total of carbon atoms in A and L together, is greater than 6; said method comprising reacting at least one of said substantially cell-membrane impermeable groups (A) with said spacer group L to which is attached at least one arsenoxide (Y).