Patent ID: 7595341
Filing Date: 2009-09-29
Classification: A61P,C07C

Abstract:
1. A method for treating an inflammatory response in a subject in need thereof, comprising administering to the subject an effective amount of a compound of structural formula (I): or a pharmaceutically acceptable salt thereof, wherein: D-E and F-G are each independently a cis or trans —C═C— or a —C≡C—; R each R W is selected from —R each R A is selected from (C1-C6) alkylene optionally substituted with 1, 2, 3, 4, 5 or 6 of the same or different halogen atoms, —(CH X is selected from —(CH Y is selected from hydrogen, (C1-C6) alkyl optionally substituted with one or more of the same or different R groups, (C5-C14) aryl optionally substituted with one or more of the same or different R groups, phenyl optionally substituted with one or more of the same or different R groups, (C6-C16) arylalkyl optionally substituted with one or more of the same or different R groups, 5-14 membered heteroaryl optionally substituted with one or more of the same or different R groups, 6-16 membered heteroarylalkyl optionally substituted with one or more of the same or different R groups, and a detectable label; each R is independently selected from an electronegative group, ═O, —OR each R each R with the proviso that when X—Y is —CH 2 CH 3 , then at least one of R 1 , R 2 or R 3 is other than hydrogen.