Patent ID: 7423049
Filing Date: 2008-09-09
Classification: A61P,C04B,C07D

Abstract:
1. A compound of the formula: wherein each of Q 1 and Q 2 are independently selected from a phenyl or 5-6 membered aromatic heterocyclic ring system, or a 8-10 membered bicyclic ring system comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring; the rings that make up Q optionally substituted with NR′ 2 , OR′, CO 2 R′ or CONR′ 2 ; NR′ 2 ; OCF 3 ; CF 3 ; NO 2 ; CO 2 R′; CONHR′; SR′; S(O 2 )N(R′) 2 ; SCF 3 ; CN; N(R′)C(O)R 4 ; N(R′)C(O)OR 4 ; N(R′)C(O)C(O)R 4 ; N(R′)S(O 2 )R 4 ; N(R′)R 4 ; N(R 4 ) 2 ; OR 4 ; OC(O)R 4 ; OP(O) 3 H 2 ; N═CH—N(R′) 2 ; 3,4-methylenedioxy; —NH—C(O)O—CH 2 -4-pyridine; —NH—C(O)CH 2 -morpholine; —NH—C(O)CH 2 -piperazine; or —NH—C(O)CH 2 -pyrrolidine; the rings that make up Q R′ is selected from hydrogen; (C phenyl or phenyl substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; or a 5-6 membered heterocyclic ring system optionally substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; R R each R is independently selected from hydrogen, —R R J is a (C D is selected from the group T is either O or NH; and G is either NH