Patent ID: 6184031
Filing Date: 2001-02-06
Classification: C07K,C12N

Abstract:
An isolated nucleic acid molecule comprising a polynucleotide sequence encoding Nramp, wherein Nramp is a transmembrane protein having at least 10 transmembrane domains and a binding-protein-dependent transport system inner membrane component signature of bacteria, which participates in substrate translocation across a membrane, and wherein said Nramp confers resistance to infection to unrelated intracellular parasites, said polynucleotide sequence selected from the group consisting of:a) SEQ ID NO:1;b) SEQ ID NO:24;c) SEQ ID NO:26;d) SEQ ID NO:29;e) SEQ ID NO:31; andf) a nucleotide sequence encoding an amino acid sequence which is at least 93% homologous to an amino acid sequence encoded by any of the polynucleotide sequences in (a) to (e).