Patent ID: 6613907
Filing Date: 2003-09-02
Classification: A61P,C07D,C12P

Abstract:
A process for production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is â€”COOH or â€”COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy, said process comprising: incubating a starting compound having a structure according to Formulae IIA and/or IIB: â€ƒwherein R3* is â€”CH3 and R1, R2, A, B, and D are defined above, in the presence of a microorganism under conditions effective to produce the product compound, wherein the microorganism is selected from the group consisting of Stemphylium consortiale, Gliocladium deliquescens, Bacillus cereus, Bacillus subtilis, Bacillus fusiformis, Botrytis allii, Cyathus striatus, Rhizopus oryzae, Pycniodosphora dispersa, Pseudomonas putida, Helicostylum piriforme, Mucor circinelloides f. griseo-cyanus, Mucor recurvatus, Mucor mucedo, Gelasionospora autosteria, Rhodotorula rubra, Mycobacterium bisrymcum, Candida guilliermondii, Candida lipolytica, Candida parasilosis var. quercus, Penicillium notatum, and Penicillium chyrsogenum.