Patent ID: 6288036
Filing Date: 2001-09-11
Classification: A61K,A61P,C07D,C07K,Y10S

Abstract:
A peptide having the formula:N-A-B-C-D-E-F-G-H-I-J-Cn, whereinN is hydrogen;A is D-Arg;B is Arg;C and D are independently selected from the group consisting of Pro and .sup.4 Hyp;E is Gly;F is selected from the group consisting of Phe, Leu, and Thi;G is a direct bond or is Ser;H is a compound of the D-configuration selected from the consisting of D-Phe and D-Tic;I is selected from the group consisting of Aoc and compounds of the formula: ##STR22##wherein R is selected from the group consisting of methyl, ethyl, propyl, isobutyl, cyclohexylmethyl, allyl, methallyl, prenyl, benzyl, phenyl, nitrophenyl, phenylpropyl, and methylbutyl, and wherein X is either sulfur or oxygen;J is Arg;Cn is a hydroxyl group;and pharmaceutically acceptable salts thereof.