Patent ID: 6468503
Filing Date: 2002-10-22
Classification: A61K,A61P,C07K,Y02P

Abstract:
A soluble precipitable material convertible into an intra-cellular precipitate which is insoluble and non-digestible in the cells of a host, the cells having natural intra-cellular enzymes and lysosomes, the soluble precipitate material when attached to a first targeting agent forming a binary reagent, which are endocytosed the cells having natural intra-cellular enzymes and having lysosomes therein, the endocytosing and the natural intra-cellular enzymes of the cells causing the soluble precipitable material when disposed in the cells to detach from the targeting agent and enabling the conversion of the soluble precipitable material into a precipitate disposed in the cells, the soluble precipitable material being selected from the group consisting of at least one of peptide, carbohydrates, synthetic polymer, and indoxyl compounds having molecular positions 1-7, the precipitate when disposed in the cells accumulating in the lysosomes within the cells and having at least one of a first antigenic epitope being an epitope which is an integral part of the structure of the precipitate, a second antigenic epitope, and a neo-antigenic third epitope, the intra-cellular precipitate then becoming the intra-cellular precipitate, which becomes a first extra-cellular precipitate.