Patent ID: 6319938
Filing Date: 2001-11-20
Classification: A61K,A61P,Y02A

Abstract:
A method for tbe prophylaxis or treatment of diabetic nephropathy or glomerulonephritis in a mammal comprising the step of administering a pharmaceutically effective amount of a compound or salt thereof represented by formula (I') ##STR16##wherein R.sup.1 stands for H or a lower (C.sub.1 -C.sub.4) alkyl, R.sup.2 stands for a group represented by the formula --CO--D"" where D"" stands for hydroxy or a lower (C.sub.1 -C.sub.4) alkoxy group, the alkyl moiety of which optionally is substituted with hydroxy, amino, halogen, lower (C.sub.2 -C.sub.6) alkanoyloxy, lower (C.sub.4 -C.sub.7) cycloalkanoyloxy, lower (C.sub.1 -C.sub.6) alkoxyearbonyloxy, lower (C.sub.3 -C.sub.7) cycloalkoxycarbonyloxy or lower (C.sub.1 -C.sub.4) alkoxy, R.sup.3 stands for a tetrazolyl, carboxyl group or a group represented by the formula: ##STR17##where i stands for --O-- or --S-- and j stands for >C.dbd.O, >C.dbd.S or >S(O).sub.m where m is 0, 1 or 2; ring A stands for a benzene ring; Y stands for O, N(H) or S, to a mammal in need threreof.