Patent ID: 6222064
Filing Date: 2001-04-24
Classification: C07B,C07C

Abstract:
A method for the fluorination of a compound selected from the group consisting of alcohols, aldehydes, ketones, epoxides, and mixtures thereof, using a fluorinating reagent comprising contacting said compound with said fluorinating reagent under conditions sufficient to fluorinate said compound wherein said fluorinating reagent is an aminosulfur trifluoride composition having a structure with one or more: ##STR67##wherein m=1-5 and R.sup.1 and R.sup.2 are:(1) when m=1, individually aryl or meta- or para-substituted aryl radicals in which the meta- or para-substitution is selected from the group consisting of normal and branched C.sub.1-10, trifluoromethyl, alkoxy, aryl C.sub.6-10, nitro, sulfonic ester, N,N-dialkylamino and halogens; or(2) when m=1, individually aryl radicals which are fused or linked to one another, or(3) when m=1, together an unsaturated cyclic ring having 2 to 4 carbon ring members and one to three heteroatoms selected from the group consisting of oxygen, nitrogen, protonated nitrogen and alkylated nitrogen wherein said ring has one to three functional groups selected from hydrogen, normal and branched C.sub.1-10 alkyl, haloalkyl, aryl halogen, cyano, nitro and amino; or(4) when m=2-5, R.sup.1 is a single phenyl radical linked to each --NSF.sub.3 radical and R.sup.2 is an aryl radical having C.sub.6 to C.sub.10 ; or(5) when m=2-5, R.sup.1 and R.sup.2 are individually divalent aryl radicals of C.sub.6 to C.sub.10 linked to adjacent --NSF.sub.3 radicals except R.sup.1 and R.sup.2 are monovalent aryl radicals having C.sub.6 to C.sub.10 where R.sup.1 and R.sup.2 are linked to only one --NSF.sub.3 radical; or(6) when m=1, one of R.sup.1 and R.sup.2 is an aryl radical and the other is an alkyl radical of C.sub.1-10.