Patent ID: 8658598
Filing Date: 2014-02-25
Classification: A61P,C07K

Abstract:
1. A recombinant melusin fusion protein having an improved stability and an improved capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said recombinant melusin fusion protein comprises: i) a cell penetrating polypeptide, and ii) a human melusin protein comprising the amino acid sequence encoded by the nucleotide sequence as defined in SEQ ID No:1, wherein the cell penetrating polypeptide is an HIV-TAT polypeptide and the cell penetrating polypeptide is conjugated to the C-terminus of the human melusin protein and wherein the N-terminus of the human melusin protein is conjugated to a tag sequence and the tag sequence is a maltose-binding protein (MBP).