Patent ID: 6787300
Filing Date: 2004-09-07
Classification: C07K,C12N,C12Q,C12R

Abstract:
A method of identifying an agent that alters the lifespan of a eukaryotic cell, the method comprising:a) providing a eukaryotic cell characterized by a first replicative capacity; b) contacting the eukaryotic cell with an agent to provide a treated eukaryotic cell, wherein the agent is a drug; c) evaluating a phenotype of the treated eukaryotic cell, in the presence of the agent, wherein the phenotype is stress survival; and d) evaluating replicative capacity of the treated eukaryotic cell in the presence of the agent, wherein modulation of the phenotype and replicative capacity, relative to a corresponding phenotype and capacity of a eukaryotic cell not contacted with the agent, identifies the agent as an agent that alters the lifespan of a eukaryotic cell.