Patent ID: 8399650
Filing Date: 2013-03-19
Classification: A61K,A61P,C07K

Abstract:
1. A vector selected from the group consisting of (i) a DNA plasmid comprising a promoter, a polyadenylation signal, a selectable marker and a DNA sequence, wherein the promoter and polyadenylation signal are operably linked to the DNA sequence, the selectable marker encodes a protein that confers resistance to an antibiotic, the promoter is a CMV promoter, and the polyadenylation signal is a bovine growth hormone polyadenylation signal; (ii) an RNA vector comprising an isolated RNA sequence that is encoded by the DNA sequence, wherein the RNA vector contains an integration site for a chromosome of a host cell; and (iii) a viral vector comprising an RNA sequence that is encoded by the DNA sequence; wherein the DNA sequence is selected from the group consisting of SEQ ID NOs: 8, 56, 126 and 130, or a variant thereof having at least 70% nucleotide sequence identity therewith, or a fragment thereof having at least 15 nucleotides, or a derivative thereof, wherein the peptide encoded by said variant, fragment or derivative has a common antigenic cross-reactivity to the peptide encoded by the DNA sequence; wherein the DNA sequence is the coding sequence of a