Patent ID: 6498246
Filing Date: 2002-12-24
Classification: C08B

Abstract:
A glycosaminoglycan derivative, or a salt thereof, having the following properties (a), (b) and (c) and comprising at least one structure represented by general formula (1) described in (d) per molecule of a backbone structure formed by a repeating unit structure of hexosamine and hexuronic acid:(a) mol % of 2-deoxy-2-sulfamino-4-O-(4-deoxy-2-O-sulfo-&agr;-L-threo-hex-4-enopyranosyluronic acid)-6-O-sulfo-D-glucose being from 0 to 10%, mol % of 2-deoxy-2-sulfamino-4-O-(4-deoxy-&agr;-L-threo-hex-4-enopyranosyluronic acid)-6-O-sulfo-D-glucose being from 95 to 70%, and mol % of 2-deoxy-2-sulfamino-4-O-(4-deoxy-&agr;-L-threo-hex-4-enopyranosyluronic acid)-D-glucose being from 5 to 20%, in a disaccharide composition obtained by a disaccharide analysis through a combination of degradation by a glycosaminoglycan degradation enzyme with analysis by high performance liquid chromatography, (b) activated partial thromboplastin time (APTT) when measured by adding to standard blood plasma at a final concentration of 3 &mgr;g/ml being 50 seconds or less, (c) weight average molecular weight being from 9,000 to 13,000 Da (dalton), and (d) general formula (1): wherein R1 represents H or SO3H; and R2 represents COCH3 or SO3H.