Patent ID: 7122519
Filing Date: 2006-10-17
Classification: A61K,C07K

Abstract:
1. A method of performing a function selected from the group consisting of I) inhibiting protein synthesis in a cell, II) inhibiting growth of a cell, III) inhibiting proliferation of a cell, IV) inhibiting tumorigenesis in a cell, and V) enhancing apoptosis of a cell, the method comprising administering to the cell a didemnin analog having the structure wherein: i) R —H, -(tert-butyloxycarbonyl), -leucine, —(N-methyl)leucine, —(N-methyl)leucine-proline, —(N-methyl)leucine-proline-lactate, —(N-methyl)leucine-proline-pyruvate, —(N-methyl)leucine-proline-lactate-(a first fluorophore), —(N-methyl)leucine-proline-lactate-glutamine-pyroglutamate, —(N-methyl)leucine-proline-lactate-glutamine-cyclopentanoate, —(N-methyl)leucine-proline-alanine-leucine-pyroglutamate, and —(N-methyl)leucine-proline-(N-methyl-alanine)-leucine-pyroglutamate; ii) R (a) R and R 3 is selected from the group consisting of —CH 3 and —H; or (b) R iii) each of R iv) R v) X is selected from the group consisting of —O— and —NH—; vi) Y is selected from the group consisting of —H and a hydroxyl protecting group; vii) R viii) the molecule is not tamandarin A and is not tamandarin B (compound 105).