Patent ID: 8562968
Filing Date: 2013-10-22
Classification: A61K,A61P,C12N

Abstract:
1. A method for inducing tolerance to an allogenic transplant in a subject, the method comprising: (a) pre-treating the subject with an immunosuppressive treatment comprising administering total body irradiation, cyclophosphamide treatment, and anti-thymocyte globulin to the subject, wherein the total body irradiation comprises exposure of the subject to about 4 Gy for each of three successive days; (b) administering to the subject a first preparation comprising a first plurality of stem cells, wherein the first plurality of stem cells are obtained from bone marrow, peripheral blood, umbilical cord, or a combination thereof, and wherein the first plurality of stem cells comprises CD6-positive cells; (c) obtaining a second preparation, wherein the obtaining comprises: (d) administering the second preparation to the subject subsequent to administering the first preparation, wherein the allogenic transplant comprises the first plurality of stem cells and the second plurality of stem cells, and further wherein the first plurality of stem cells and the second plurality of stem cells differ from the subject in up to 6 HLA antigens, whereby tolerance to an allogenic transplant in the subject is induced.