Patent ID: 8987322
Filing Date: 2015-03-24
Classification: A61K,A61P,C07D

Abstract:
1. A method of increasing the hepatic bioavailability of atorvastatin, or a pharmaceutically acceptable salt thereof, comprising administering to a subject a therapeutically effective amount of atorvastatin, or a pharmaceutically acceptable salt thereof, in a pharmaceutical formulation, wherein the formulation is a matrix-based tablet comprising: (a) atorvastatin, or a pharmaceutically acceptable salt thereof, (b) dimethyl sulfoxide, (c) sodium lauryl sulfate, and (d) polyvinyl pyrrolidone, wherein (a), (b), (c), and (d) are compressed into a polymer matrix comprising hydroxypropylmethyl cellulose and wherein the formulation releases atorvastatin, or a pharmaceutically acceptable salt thereof, at a rate that avoids saturating the intestinal and hepatocytic transport mechanisms.