Patent ID: 7414057
Filing Date: 2008-08-19
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein m is 1 or 2; each p is independently 0, 1, or 2; each n is independently 0, 1, or 2; R R in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 11 ; and alkyl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R 11 and oxo; or R or R or R or R R in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 11 ; and alkyl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R 11 and oxo; or R or R R wherein phenyl, naphthyl, heteroaryl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy; and wherein any methylene (CH 2 ) carbon atom in R 11 is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; or two substituents when on the same methylene (CH 2 ) carbon atom are taken together with the carbon atom to which they are attached to form a cyclopropyl group; each R wherein any methylene (CH 2 ) carbon atom in R 12 is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; or two R 12 groups together with the atom to which they are attached form a 5- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and NC 1-4 alkyl; each R wherein alkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from halogen, hydroxy, C 1-3 alkoxy, C 1-3 alkylthio, carboxy, C 1-4 alkyloxycarbonyl, amino, C 1-4 alkylamino, and di(C 1-4 alkylamino); or two R X is selected from the group consisting of wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R 11 ; alkyl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R 11 and oxo; and wherein any methylene (CH 2 ) carbon atom in X is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; and Y is C