Patent ID: 6495580
Filing Date: 2002-12-17
Classification: C07D

Abstract:
A compound having the formula: wherein Het represents an unsubstituted or substituted five to seven membered heterocyclic ring containing one to three heteroatoms selected from nitrogen, oxygen or sulfur, said heterocyclic ring substituents being at least one selected from those consisting of alkyl, amino, monoalkylamino or dialkylamino;R1 represents a radical selected from the group consisting of halogen; perfluoroalkyl; alkoxyalkyl; amino; alkylamino; dialkylamino; amido; alkylaminoalkyl; an unsubstituted or substituted, saturated or unsaturated straight- or branched-chain alkyl radical, said alkyl chain substituent being at least one hydroxy group; carboxy; an unsubstituted or substituted phenyl radical (C6H5), said phenyl radical substituent being at least one selected from the group consisting of hydroxy, halogen, perfluoroalkyl, thio, nitro, carboxy, carboxyalkyl, carbalkoxy, carbalkoxyalkyl, carboxamide, carboamidoalkyl, alkyl, cycloalkyl, alkoxy, alkoxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfonamide, amidino, cyano, amino, amido, alkylamino, dialkylamino, alkylaminoalkyl, or alkoxy monosubstituted with a substituent selected from the group consisting of carboxy, amino, alkylamino or dialkylamino; a cycloalkyl radical; or a heterocyclic radical selected from the group consisting of pyridine, thiophene, oxazole, oxadiazole, thiadiazole, pyrazole, tetrazole, furan, pyrrole, isoxazole, imidazole, triazole and thiazole, including all positional isomers of said heterocyclic radicals; R2 represents a radical selected from the group consisting of hydrogen, hydroxy, thio, alkoxy, carboxy, carboxyalkyl, amino, alkylamino, dialkylamino, carboxamide, carboxamidoalkyl, or sulfonamide; X represents a divalent linking moiety selected from the group consisting of â€”N&boxH;CHâ€”, â€”CH&boxH;Nâ€”, â€”(CH2)nâ€”NHâ€”, â€”NHâ€”(CH2)nâ€”, â€”(CH2)nâ€”, â€”CH&boxH;CHâ€” or â€”N&boxH;Nâ€”, n being an integer from 1 to 8; Z represents a substituent selected from the group consisting of formyl, hydroxy or â€”Xâ€”Het, wherein X and Het are as previously defined; the isomeric forms of said compound and the pharmaceutically acceptable salts of said compound.