Patent ID: 7196056
Filing Date: 2007-03-27
Classification: A01N,A61F,A61K,A61L,C07K,G01N

Abstract:
1. A method of inducing kidney tissue growth in a mammal comprising contacting said kidney tissue with a morphogen such that the morphogen, when contacted with the kidney tissue, is capable of inducing the developmental cascade of tissue morphogenesis in said kidney tissue; wherein said morphogen has an amino acid sequence selected from: (a) a sequence having at least 70% homology with the C-terminal seven-cysteine skeleton of human OP-1, amino acids 38–139 of SEQ ID NO: 5; (b) an amino acid substitution variant defined by Generic Sequence 3, SEQ ID NO: 3; (c) an amino acid substitution variant defined by Generic Sequence 4, SEQ ID NO: 4; and, and wherein said morphogen induces endochondral bone formation in an in vivo assay and induces kidney tissue growth.