Patent ID: 9128046
Filing Date: 2015-09-08
Classification: B01L,G01N

Abstract:
1. A slide holder assembly for use in high-content screening, the slide holder assembly configured to receive a slide holding a plurality of biological cells, the slide having a top surface and an opposing bottom surface, the slide holder assembly comprising: a slide holder having a perimeter sidewall with a top surface and an opposing bottom surface, an inside surface extending between the top and bottom surfaces of the sidewall so as to bound an opening extending completely through the slide holder, the inside surface having a flange extending into the opening, the slide holder being configured to receive the slide in the opening so that the slide rests on the flange; a slide cover at least partially disposed within the opening of the slide holder, the slide cover having a perimeter sidewall with a top surface and an opposing bottom surface, an inside surface extending between the top and bottom surfaces of the sidewall, the inside surface bounding an opening extending completely through the slide cover between the top and bottom surfaces of the slide cover, the slide cover being removably securable to the slide holder when positioned within the opening of the slide holder; a pair of electrodes positioned within the opening of the slide cover on opposite ends thereof; and a removable seal configured to be positioned between the slide cover and the slide so as to be aligned between the flange and the perimeter sidewall of the slide cover, such that when the slide is positioned within the opening of the slide holder so as to rest on the flange and the slide cover is secured to the slide holder with the seal positioned between the slide and the slide cover so as to be aligned with the flange, the slide is secured within the slide holder assembly and the inside surface of the slide cover and the top surface of the slide combine to form a cavity having an open top end, the cavity being watertight and configured to hold a liquid therein.