Patent ID: 8808667
Filing Date: 2014-08-19
Classification: A61K,A61P,C07K

Abstract:
1. A method for generating in vitro an antibody, or one of its functional fragments directed against a tumoral antigen expressed at the surface of a tumor resistant to at least one anti-tumoral compound, the method comprising a step consisting of immunizing animals directly with a milled homogenate and/or a suspension and/or a cell lysate stemming from said resistant tumor, and a step consisting of selecting antibodies recognizing the resistant tumor and not the native tumor from which the resistant tumor stems, characterized in that said resistant tumor is obtained directly by biopsy and/or surgery of a patient following, or having followed, a therapeutic treatment with at least said anti-tumoral compound having induced the resistance of the tumor, and in that said at least one anti-tumoral compound is a monoclonal antibody.