Patent ID: 9206482
Filing Date: 2015-12-08
Classification: C12Q

Abstract:
1. A method, comprising: (a) assaying by sequencing, array hybridization or nucleic acid amplification the expression level of each of a first group of transcripts and a second group of transcripts in a fine needle aspirate test sample from a thyroid nodule of a subject, wherein said first group of transcripts includes least two transcripts corresponding to at least two sequences selected from SEQ ID No. 1-4 and 8-282, and said second group of transcripts includes at least two transcripts corresponding to at least two sequences selected from SEQ ID No. 5-7 and 283-659; and (b) in a programmed computer, comparing said expression level of each of said first group of transcripts and second group of transcripts with reference expression levels of transcripts corresponding to sequences as set forth in SEQ ID No. 1 to 659 to (1) classify said thyroid nodule as malignant if there is an increase in an expression level corresponding to said first group or a decrease in an expression level corresponding to said second group, or (2) classify said thyroid nodule as benign if there is an increase in said expression level corresponding to said second group or a decrease in said expression level corresponding to said first group.