Patent ID: 8197759
Filing Date: 2012-06-12
Classification: C07F,G01N,Y10T

Abstract:
1. An optical labeling molecule for labeling a target analyte comprising: (a) a zwitterionic dye moiety comprising at least one positive or at least one negative charge moiety added to obtain a net neutral charge, wherein the positive charge moiety is selected from a group consisting of a quaternary ammonium group and a guanidinium group, wherein the positive charge moiety is not titratable between the pH of 3-12, and wherein the negative charge moiety is selected from the group consisting of a sulfonate group and a sulfate group, wherein the negative charge moiety is not titratable between the pH of 3-12; (b) a functional linker moiety; (c) an optional titratable group moiety, wherein the titratable group closely approximates the pK of the group removed from the analyte by reaction with the functional linker; and (d) an optional cleavable moiety.