Patent ID: 7402394
Filing Date: 2008-07-22
Classification: A01K,A61K,A61P,C07K,C12Q

Abstract:
1. A method of screening for a substance which activates or inhibits activity of Aster Associated Protein (ASAP) or an ortholog thereof, said substance being selected from the group consisting of a human protein of sequence SEQ ID NO: 1 and proteins having sequences which exhibit at least 80% identity or at least 90% similarity, with an entire sequence SEQ ID NO: 1, wherein intracellular over-expression of said ASAP or an ortholog thereof disturbs organization of a mitotic spindle, wherein said method comprises the steps of: a) contacting, in a first step, cells of a biological sample expressing said ASAP or an ortholog thereof, with a substance to be tested; b) measuring in a second step, the effect of said substance on mitolic spindle organization or the rate of induction of aberrant and abortive mitoses; c) comparing, in a third step, the measured effect of said substance to a previously measured effect in an absence of said substance to determine a relative effect of said substance; and d) selecting, in a fourth step, a substance which activates or inhibits said activity.