Patent ID: 6638950
Filing Date: 2003-10-28
Classification: A61P,C07D

Abstract:
A compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein:M selected from CH2, CHR5, CHR13, CR13R13, and CR5R13; Q is selected from CH2, CHR5, CHR13, CR13R13, and CR5R13; K is selected from CH2, CHR5 and CHR6; J and L are independently selected from CH2, CHR5, CHR6, CR6R6 and CR5R6; with the proviso that at least one of M, J, K, L, or Q contains an R5; Z is selected from O, S, NR1a, C(CN)2, CH(NO2), and CHCN; R1a is selected from H, C1-6 alkyl, C3-6 cycloalkyl, CONR1bR1b, OR1b, CN, NO2, and (CH2)wphenyl; R1b is independently selected from H, C1-3 alkyl, C3-6 cycloalkyl, and phenyl; E is â€”(C&boxH;O)â€”(CR9R10)vâ€”(CR11R12)â€”, â€”(SO2)â€”(CR9R10)vâ€”(CR11R12)â€”, Ring A is a C3-8 carbocyclic residue; R2 is selected from H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, and a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 Ra; Ra, at each occurrence, is selected from C1-4 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNRbRb, (CH2)rOH, (CH2)rORc, (CH2)rSH, (CH2)rSRc, (CH2)rC(O)Rb, (CH2)rC(O)NRbRb, (CH2)rNRbC(O)Rb, (CH2)rC(O)ORb, (CH2)rOC(O)Rc, (CH2)rCH(&boxH;NRb)NRbRb, (CH2)rNHC(&boxH;NRb)NRbRb, (CH2)rS(O)pRc, (CH2)rS(O)2NRbRb, (CH2)rNRbS(O)2Rc, and (CH2)rphenyl; Rb, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; Rc, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl; R3 is selected from a (CR3â€²R3â€³)râ€”C3-8 carbocyclic residue substituted with 0-5 R15; a (CR3â€²R3â€³)râ€”C9-10 carbocyclic residue substituted with 0-4 R15; and a (CR3â€²R3â€³)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15; R3â€² and R3â€³, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; R5 is selected from a (CR5â€²R5â€³)tâ€”C3-10 carbocyclic residue substituted with 0-5 R16 and a (CR5â€²R5â€³)t-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16; R5â€² and R5â€³, at each occurrence, are selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl; R6, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rNR6aR6aâ€², (CH2)rOH, (CH2)rOR6b, (CH2)rSH, (CH2)rSR6b, (CH2)rC(O)OH, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6aâ€², (CH2)rNR6dC(O)R6a, (CH2)rC(O)OR6b, (CH2)rOC(O)R6b, (CH2)rS(O)pR6b, (CH2)rS(O)2NR6aR6aâ€², (CH2)rNR6dS(O)2R6b, and (CH2)tphenyl substituted with 0-3 R6c; R6a and R6aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c; R6b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c; R6c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d; R6d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; with the proviso that when any of J, K, or L is CR6R6 and R6 is halogen, cyano, nitro, or bonded to the carbon to which it is attached through a heteroatom, the other R6 is not halogen, cyano, or bonded to the carbon to which it is attached through a heteroatom; R9, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, F, Cl, Br, I, NO2, CN, (CHRâ€²)rOH, (CH2)rOR9d, (CH2)rSR9d, (CH2)rNR9aR9aâ€², (CH2)rC(O)OH, (CH2)rC(O)R9b, (CH2)rC(O)NR9aR9aâ€², (CH2)rNR9aC(O)R9a, (CH2)rNR9aC(O)H, (CH2)rC(O)OR9b, (CH2)rOC(O)R9b, (CH2)rOC(O)NR9aR9aâ€², (CH2)rNR9aC(O)OR9b, (CH2)rS(O)pR9b, (CH2)rS(O)2NR9aR9aâ€², (CH2)rNR9aS(O)2R9b, C1-6 haloalkyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R9c, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9c; R9a and R9aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R9e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9e; alternatively, R9a and R9aâ€², along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR9g, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R9b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R9e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R9e; R9c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR9fR9f, (CH2)rOH, (CH2)rOR9b, (CH2)rSR9b, (CH2)rC(O)OH, (CH2)rC(O)R9b, (CH2)rC(O)NR9fR9f, (CH2)rNR9fC(O)R9a, (CH2)rC(O)OR9b, (CH2)rOC(O)R9b, (CH2)rC(&boxH;NR9f)NR9fR9f, (CH2)rS(O)pR9b, (CH2)rNHC(&boxH;NR9f)NR9fR9f, (CH2)rS(O)2NR9fR9f, (CH2)rNR9fS(O)2R9b, and (CH2)rphenyl substituted with 0-3 R9e; R9d, at each occurrence, is selected from C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, a C3-10 carbocyclic residue substituted with 0-3 R9c, and a 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R9c; R9e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR9fR9f, and (CH2)rphenyl, wherein the phenyl on the (CH2)rphenyl is substituted with 0-5 substituents selected from F, Cl, Br, I, NO2, C1-6 alkyl, OH, and NR9fR9f; R9f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R9g is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R9f, C(O)OR9h, and SO2R9h; R9h, at each occurrence, is selected from C1-6 alkyl, and C3-6 cycloalkyl; R10, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, F, Cl, Br, I, NO2, CN, (CHRâ€²)rOH, (CH2)rOR10d, (CH2)rSR10d, (CH2)rNR10aR10aâ€², (CH2)rC(O)OH, (CH2)rC(O)R10b, (CH2)rC(O)NR10aR10aâ€², (CH2)rNR10aC(O)R10a, (CH2)rNR10aC(O)H, (CH2)rC(O)OR10b, (CH2)rOC(O)R10b, (CH2)rOC(O)NR10aR10aâ€², (CH2)rNR10aC(O)OR10b, (CH2)rS(O)pR10b, (CH2)rS(O)2NR10aR10aâ€², (CH2)rNR10aS(O)2R10b, C1-6 haloalkyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R10c, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R10c; R10a and R10aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R10e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R10e; alternatively, R10a and R1aâ€², along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR10g, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R10b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R10e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R10e; R10c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR10fR10f, (CH2)rOH, (CH2)rOR10b, (CH2)rSR10b, (CH2)rC(O)OH, (CH2)rC(O)R10b, (CH2)rC(O)NR10fR10f, (CH2)rNR10fC(O)R10a, (CH2)rC(O)OR10b, (CH2)rOC(O)R10b, (CH2)rC(&boxH;NR10f)NR10fR10f, (CH2)rS(O)pR10b, (CH2)rNHC(&boxH;NR10f)NR10fR10f, (CH2)rS(O)2NR10fR10f, (CH2)rNR10fS(O)2R10b, and (CH2)rphenyl substituted with 0-3 R10e; R10d, at each occurrence, is selected from C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R10c; R10e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR10fR10f, and (CH2)rphenyl; R10f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R10g is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R10f, SO2R10h, and C(O)O R10h; R10h, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl; alternatively, R9 and R10 join to form &boxH;O, a C3-10 cycloalkyl, a 5-6-mernbered lactone or lactam, or a 4-6-membered saturated heterocycle containing 1-2 heteroatoms selected from O, S, and NR10g and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; with the proviso that when either of R9 or R10 is bonded to the carbon to which it is attached through a heteroatom, then the other of R9 or R10 is not halogen, cyano, or bonded to the carbon to which it is attached through a heteroatom; R11, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CRâ€²R17)qOH, (CH2)qSH, (CRâ€²R17)qOR11d, (CH2)qSR11d, (CRâ€²R17)qNR11aR11aâ€²,(CH2)rC(O)OH, (CH2)rC(O)R11b, (CH2)rC(O)NR11aR11aâ€², (CH2)qNR11aC(O)R11a, (C2)qOC(O)NR11aR11aâ€², (CH2)qNR11aC(O)OR11b, (CH2)qNR11aC(O)NHR11a, (CH2)rC(O)OR11b, (CH2)qOC(O)R11b, (CH2)qS(O)pR11b, (CH2)qS(O)2NR11aR11aâ€², (CH2)qNR11aS(O)2R11b, C1-6 haloalkyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R11c, and a (Râ€²R17)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R11c; R11a and R11aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R11e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R11e; alternatively, R11a and R11aâ€² along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR11g, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R11b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R11e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R11e; R11c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR11fR11f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R11b, (CH2)rC(O)NR11fR11f, (CH2)rNR11fC(O)R11a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R11b, (CH2)rC(&boxH;NR11f)NR11fR11f, (CH2)rNHC(&boxH;NR11f)NR11fR11f, (CH2)rS(O)pR11b, (CH2)rS(O)2NR11fR11f, (CH2)rNR11fS(O)2R11b, and (CH2)rphenyl substituted with 0-3 R11e; R11d, at each occurrence, is selected from C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R11c; R11e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR11fR11f, and (CH2)rphenyl, wherein the phenyl on the (CH2)rphenyl is substituted with 0-5 substituents selected from F, Cl, Br, I, NO2, C1-6 alkyl, OH, and NR9fR9f; R11f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R11g is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R11f, C(O)OR11h, and SO2R11h; R11h, at each occurrence, is selected from C1-6 alkyl, and C3-6 cycloalkyl; R12, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CHRâ€²)qOH, (CH2)qSH, (CHRâ€²)qOR12d, (CH2)qSR12d, (CHRâ€²)qNR12aR12aâ€², (CH2)rC(O)OH, (CH2)rC(O)R12b, (CH2)rC(O)NR12aR12aâ€², (CH2)qNR12aC(O)R12a, (CH2)rOC(O)NR12aR12aâ€², (CH2)rNR12aC(O)OR12b, (CH2)qNR12aC(O)NHR12a, (CH2)rC(O)OR12b, (CH2)qOC(O)R12b, (CH2)qS(O)pR12b, (CH2)qS(O)2NR12aR12aâ€², (CH2)qNR12aS(O)2R12b, C1-6 haloalkyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R12c, and a (Râ€²R17)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R12c; R12a and R12aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R12e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R12e; alternatively, R12a and R12aâ€², along with the N to which they are attached, join to form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR12g, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R12b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-2 R12e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R12e; R12c, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR12fR12f, (CH2)rOH, (CH2)rOC1-4 alkyl, (CH2)rSC1-4 alkyl, (CH2)rC(O)OH, (CH2)rC(O)R12b, (CH2)rC(O)NR12fR12f, (CH2)rNR12fC(O)R12a, (CH2)rC(O)OC1-4 alkyl, (CH2)rOC(O)R12b, (CH2)rC(&boxH;NR12f)NR12fR12f, (CH2)rNHC(&boxH;NR12f)NR12fR12f, (CH2)rS(O)pR12b, (CH2)rS(O)2NR12fR12f, (CH2)rNR12fS(O)2R12b, and (CH2)rphenyl substituted with 0-3 R12e; R12d, at each occurrence, is selected from methyl, CF3, C2-6 alkyl substituted with 0-3 R12e, C3-6 alkenyl, C3-6 alkynyl, and a C3-10 carbocyclic residue substituted with 0-3 R12c; R12e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR12fR12f, and (CH2)rphenyl; R12f, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R12g is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R12f, C(O)OR12h, and SO2R12h; R12h, at each occurrence, is selected from C1-6 alkyl, and C3-6 cycloalkyl; alternatively, R11 and R12 join to form a C3-10 cycloalkyl, a 5-6-membered lactone or lactam, or a 4-6-membered saturated heterocycle containing 1-2 heteroatoms selected from O, S, and NR11g and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R13, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, (CF2)wCF3, (CH2)qNR13aR13aâ€², (CHRâ€²)qOH, (CH2)qOR13b, (CH2)qSH, (CH2)qSR13b, (CH2)wC(O)OH, (CH2)wC(O)R13b, (CH2)wC(O)NR13aR13aâ€², (CH2)qNR13dC(O)R13a, (CH2)wC(O)OR13b, (CH2)qOC(O)R13b, (CH2)wS(O)pR13b, (CH2)wS(O)2NR13aR13aâ€², (CH2)qNR13dS(O)2R13b, and (CH2)w-phenyl substituted with 0-3 R13c; R13a and R13aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c; R13b, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R13c; R13c, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR13dR13d; R13d, at each occurrence, is selected from H, C1-6 alkyl, and C3-6 cycloalkyl; R14, at each occurrence, is selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHRâ€²)rNR14aR14aâ€², (CHRâ€²)rOH, (CHRâ€²)rO(CHRâ€²)rR14d, (CHRâ€²)rSH, (CHRâ€²)rC(O)H, (CHRâ€²)rS(CHRâ€²)rR14d, (CHRâ€²)rC(O)OH, (CHRâ€²)rC(O) (CHRâ€²)rR14b, (CHRâ€²)rC(O)NR14aR14aâ€², (CHRâ€²)rNR14fC(O) (CHRâ€²)rR14b, (CHRâ€²)rOC(O)NR14aR14aâ€², (CHRâ€²)rNR14fC(O)O(CHRâ€²)rR14b, (CHRâ€²)rC(O)O(CHRâ€²)rR14d, (CHRâ€²)rOC(O) (CHRâ€²)rR14b, (CHRâ€²)rC(&boxH;NR14f)NR14aR14aâ€², (CHRâ€²)rNHC(&boxH;NR14f)NR14fR14f, (CHRâ€²)rS(O)p(CHRâ€²)rR14b, (CHRâ€²)rS(O)2NR14aR14aâ€², (CHRâ€²)rNR14fS(O)2(CHRâ€²)rR14b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 Râ€², C2-8 alkynyl substituted with 0-3 Râ€², (CHRâ€²)rphenyl substituted with 0-3 R14e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e, or two R14 substituents on adjacent atoms on ring A form to join a 5-6 membered heterocyclic system containing 1-3 heteroatoms selected from N, O, and S substituted with 0-2 R15e; R14a and R14aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R14e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R14e; R14b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-3 R14e, and (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R14e; R14d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R14e, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R14e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R14e; R14e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR14fR14f, and (CH2)rphenyl; R14f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; R15, at each occurrence, is selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CRâ€²R17)rNR15aR15aâ€², (CRâ€²R17)rOH, (CRâ€²R17)rO(CHRâ€²)rR15d, (CRâ€²R17)rSH, (CRâ€²R17)rC(O)H, (CRâ€²R17)rS(CHRâ€²)rR15d, (CRâ€²R17)rC(O)OH, (CRâ€²R17)rC(O) (CHRâ€²)rR15b, (CRâ€²R17)rC(O)NR15aR15aâ€², (CRâ€²R17)rNR15fC(O) (CHRâ€²)rR15b, (CRâ€²R17)rOC (O)NR15aR15aâ€², (CRâ€²R17)rNR15fC(O)O(CHRâ€²)rR15b, (CRâ€²R17)rNR15fC(O)NR15fR15f, (CRâ€²R17)rC(O)O(CHRâ€²)rR15d, (CRâ€²R17)rOC(O)(CHRâ€²)rR15b, (CRâ€²R17)rC(&boxH;NR15f)NR15aR15aâ€², (CRâ€²R17)rNHC(&boxH;NR15f)NR15fR15f, (CRâ€²R17)rS(O)p(CHRâ€²)rR15b, (CRâ€²R17)rS(O)2NR15aR15aâ€², (CRâ€²R17)rNR15fS(O)2(CHRâ€²)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 Râ€², C2-8 alkynyl substituted with 0-3 Râ€², (CRâ€²R17)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; R15a and R15aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; alternatively, R15a and R15aâ€², along with the N to which they are attached, jointo form a 5-6 membered heterocyclic system containing 1-2 heteroatoms selected from NR15h, O, and S and optionally fused with a benzene ring or a 6-membered aromatic heterocycle; R15b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-6 carbocyclic residue substituted with 0-3 R15e, and (CH2)r-5-6membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e; R15d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R15e, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R15e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e; R15e, at each occurrence, is selected from C1-6 alkyl, 2-cyanoethyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, (CH2)rphenyl, and a heterocycle substituted with 0-1 R15g, wherein the heterocycle is selected from imidazole, thiazole, oxazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, isoxazole, and tetrazole,; R15f, at each occurrence, is selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl; R15g is selected from methyl, ethyl, acetyl, and CF3; R15h is selected from H, C1-6 alkyl, C3-6 cycloalkyl, (CH2)rphenyl, C(O)R15f, C(O)OR15i, and SO2R15i; R15i, at each occurrence, is selected from C1-6 alkyl, C3-6 cycloalkyl; R16, at each occurrence, is selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHRâ€²)rNR16aR16aâ€², (CHRâ€²)rOH, (CHRâ€²)rO(CHRâ€²)rR16d, (CHRâ€²)rSH, (CHRâ€²)rC(O)H, (CHRâ€²)rS(CHRâ€²)rR16d, (CHRâ€²)rC(O)OH, (CHRâ€²)rC(O)(CHRâ€²)rR16b, (CHRâ€²)rC(O)NR16aR16aâ€², (CHRâ€²)rNR16fC(O) (CHRâ€²)rR16b, (CHRâ€²)rC(O)O(CHRâ€²)rR16d, (CHRâ€²)rOC(O) (CHRâ€²)rR16b, (CHRâ€²)rC(&boxH;NR16f)NR16aR16aâ€², (CHRâ€²)rNHC(&boxH;NR16f)NR16fR16f, (CHRâ€²)rS(O)p(CHRâ€²)rR16b, (CHRâ€²)rS(O)2NR16aR16aâ€², (CHRâ€²)rNR16fS(O)2(CHRâ€²)rR16b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 Râ€², C2-8 alkynyl substituted with 0-3 Râ€², and (CHRâ€²)rphenyl substituted with 0-3 R16e; R16a and R16aâ€², at each occurrence, are selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-5 R16e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e; R16b, at each occurrence, is selected from C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, a (CH2)rC3-6 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R16e; R16d, at each occurrence, is selected from C3-8 alkenyl, C3-8 alkynyl, methyl, CF3, C2-6 alkyl substituted with 0-3 R16e, a (CH2)râ€”C3-10 carbocyclic residue substituted with 0-3 R16e, and a (CH2)r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16e; R16e, at each occurrence, is selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR16fR16f, and (CH2)rphenyl; R16f, at each occurrence, is selected from H, C1-5 alkyl, and C3-6 cycloalkyl, and phenyl; R17, at each occurrence, is independently selected from H and methyl; Râ€², at each occurrence, is selected from H, C1-6 alkyl, C3-8 alkenyl, C3-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e; g is selected from 0, 1, 2, 3, and 4; v is selected from 0, 1, and 2; t is selected from 1 and 2; w is selected from 0 and 1; r is selected from 0, 1, 2, 3, 4, and 5; q is selected from 1, 2, 3, 4, and 5; and