Patent ID: 6482932
Filing Date: 2002-11-19
Classification: A61K,C07H,C12N,C12Y

Abstract:
An enzymatic nucleic acid molecule having formula II: wherein each X, Y, and Z represents independently a nucleotide which may be the same or different; q is an integer ranging from 3 to 100; m is an integer ranging from 1 to 10; n is an integer ranging from 1 to 10; o is an integer ranging from 3 to 100; Zâ€² is a nucleotide complementary to Z; Yâ€² is a nucleotide complementary to Y; each X(q) and X(o) are oligonucleotides which are of sufficient length to stably interact independently with a target RNA sequence of Hepatitis C virus; W is a linker ranging from 2 to 70 nucleotides; A, U, G, and C represent nucleotides; C is 2â€²-deoxy-2â€²-amino cytidine, or 2â€²-O-amino cytidine; and   represents a chemical bond or chemical linkage.