Patent ID: 8133709
Filing Date: 2012-03-13
Classification: G01N

Abstract:
1. A method of labeling a carrier molecule, comprising: a) providing a bonding partner comprising the carrier molecule and a target sequence, and b) contacting the bonding partner with a biarsenical molecule under conditions wherein the biarsenical molecule reacts with the target sequence, wherein the target sequence comprises Cys-Cys-X X X X wherein the biarsenical molecule has the formula: and tautomers, anhydrides, and salts thereof; wherein: 1,3-propanediyl, 1,2 benzenediyl, 4-methyl-1,2-benzenediyl, 1,2-cyclopentanediyl, 1,2-cyclohexanediyl, 3-hydroxy-1,2-propanediyl, 3-sulfo-1,2-propanediyl, or 1,2-bis(carboxy)-1,2-ethanediyl; wherein: (i) one of R (ii) one of R wherein the Spiro linkage is formed at C