Patent ID: 7935351
Filing Date: 2011-05-03
Classification: A61K,A61P,C12N

Abstract:
1. A method of inducing production of vascular endothelial growth factor by a cell, comprising contacting the cell with a CpG oligodeoxynucleotide of 8 to 30 nucleotides in length, wherein the CpG oligodeoxynucleode is (1) a K-type oligodexoynucleotide comprising (a) a nucleic acid sequence as set forth as: wherein at least one nucleotide separates consecutive CpGs; D is adenine, guanine, or thymidine; Y is cytosine or thymine, N is any nucleotide and N wherein at least one nucleotide separates consecutive CpGs; RD is selected from the group consisting of GpT, GpG, GpA, ApT and ApA; YT is selected from the group consisting of TpT or CpT; N is any nucleotide and N (2) a D-type oligodeoxynucleotide comprising a sequence set forth as: wherein the central CpG motif is unmethylated, R is a purine nucleotide, Y is a pyrimidine nucleotide, N is any nucleotide, X is any integer from 0 to 10, and Z is any integer from 4 to 10, thereby inducing the production of vascular endothelial growth factor by the cell.