Patent ID: 9181333
Filing Date: 2015-11-10
Classification: A61K,A61P,C07K,C12Q

Abstract:
1. An isolated monoclonal antibody that specifically binds human R-spondin 3 (RSPO3), which comprises: (a) a heavy chain CDR1 comprising KASGYTFTDYS (SEQ ID NO:9), KASGYTFTSYTF (SEQ ID NO:34), or DYSIH (SEQ ID NO:78), a heavy chain CDR2 comprising IYPSNGDS (SEQ ID NO:10) or YIYPSNGDSGYNQKFK (SEQ ID NO:79), and a heavy chain CDR3 comprising ATYFANYFDY (SEQ ID NO:11), ATYFANNFDY (SEQ ID NO:35), or TYFANNFD (SEQ ID NO:80); and (b) a light chain CDR1 comprising QSVDYDGDSYM (SEQ ID NO:12) or KASQSVDYDGDSYMN (SEQ ID NO:81), a light chain CDR2 comprising AAS (SEQ ID NO:13) or AASNLES (SEQ ID NO:82), and a light chain CDR3 comprising QQSNEDPLT (SEQ ID NO:14) or QQSNEDPLTF (SEQ ID NO:83).