Patent ID: 8828431
Filing Date: 2014-09-09
Classification: A61K,A61P

Abstract:
1. A method of treating a medical condition comprising administering to a patient suffering from said condition a therapeutically effective amount of a hydrophilic or macromolecular drug used in treating the condition together with an absorption enhancer, wherein said drug and said absorption enhancer are in the form of a solid oral dosage form which consists of a pharmaceutical composition consisting of: (A) a therapeutically effective amount of said hydrophilic or macromolecular drug; (B) one or more absorption enhancers, each of which: (i) is a solid at room temperature; (ii) is a salt of a medium chain fatty acid having a carbon length of from 8 to 14 carbon atoms; and (iii) is present in the dosage form such that the ratio of the drug to the one or more absorption enhancers is 1:100,000 to 10:1; (C) one or more excipients selected from the group consisting of rate-controlling polymeric materials, diluents, lubricants, disintegrants, plasticizers, anti-tack agents, opacifying agents, pigments, and flavorings; and optionally, a controlled release coating; wherein the solid oral dosage form is a tablet, a multiparticulate compressible to form a tablet, or a capsule containing a multiparticulate compressible to form a tablet.