Patent ID: 8129169
Filing Date: 2012-03-06
Classification: C07D,C12N,C12P,Y02E

Abstract:
1. A non-naturally occurring bacterial organism, comprising a 1,4-butanediol (BDO) pathway comprising BDO pathway enzymes expressed in a sufficient amount to produce BDO, wherein said bacterial organism is genetically modified, and wherein said bacterial organism: (A) comprises a BDO pathway selected from: (i) a BDO pathway comprising: (ii) a BDO pathway comprising: (iii) a BDO pathway comprising: (iv) a BDO pathway comprising: (B) comprises disruption of a gene encoding a protein in an aerobic respiratory control regulatory system; expresses an exogenous NADH insensitive citrate synthase; or expresses exogenous phosphoenolpyruvate carboxykinase.