Patent ID: 8916714
Filing Date: 2014-12-23
Classification: A61P,B01J,C07D,Y02P

Abstract:
1. A production method comprising reacting a compound represented by the following formula (1) (wherein in formula (1), R R A represents a hydrogen atom, a C A may be substituted with 1 to 3 substituents, such substituents include a group selected from the group consisting of a halogen atom, a C X represents a bond (only when A is a phenyl group or a fluorine atom), or an oxygen atom; and Y represents a leaving group), and a compound represented by the following formula (2) (wherein in formula (2), H represents a hydrogen atom; R R R R in the presence of (i) a palladium compound, (ii) a ligand capable of coordinating to the palladium compound or a salt thereof, (iii) a base, (iv) a C (v) at least one additive selected from the group of consisting of copper, silver, and salts thereof, and complexes thereof; to produce a phenyl-substituted heterocyclic derivative represented by the following formula (3) (Wherein in formula (3), the definition of A, X, R