Patent ID: 8309150
Filing Date: 2012-11-13
Classification: A61K,A61P,C07C

Abstract:
1. A method of producing a chlorogenic acid composition, said method comprising: allowing a water-soluble composition that contains monocaffeoylquinic acid, ferulaquinic acid and dicaffeoylquinic acid and that is extracted from raw coffee beans or roasted coffee beans to be adsorbed to a column filled with an adsorbent selected from the group consisting of styrene-divinylbenzene, modified styrene-divinylbenzene and methyl methacrylate type adsorbents; and then eluting a chlorogenic acid composition adsorbed on the column by passing a 0.5 to 10 vol % ethanol aqueous solution; wherein the extraction from the raw coffee beans or roasted coffee beans is performed for 10 to 120 minutes with water at a temperature of from 70° C. to boiling; and wherein the mass ratio of the chlorogenic acid composition denoted by ((A)+(B))/((A)+(B)+(C)) is 0.85 or more, wherein (A) is monocaffeoylquinic acid, (B) is ferulaquinic acid and (C) is dicaffeoylquinic acid; and the mass ratio of caffeine in the chlorogenic acid composition denoted by (D)/((A)+(B)+(C)) is 0.014 or less, wherein (A) is monocaffeoylquinic acid, (B) is ferulaquinic acid, (C) is dicaffeoylquinic acid and (D) is caffeine.