Patent ID: 7875609
Filing Date: 2011-01-25
Classification: C07D

Abstract:
1. A compound of formula (I): wherein: Y is oxygen; R R or R wherein the group c consists of: halogen atoms, hydroxyl, carboxyl, linear and branched alkyl, hydroxyalkyl, haloalkyl, thioalkyl, alkenyl, and alkynyl groups; linear and branched alkoxyl groups; linear and branched alkylthio groups; hydroxycarbonylalkyl; alkylcarbonyl; alkoxycarbonylalkyl; alkoxycarbonyl; trifluoromethyl; trifluoromethoxyl; —CN; —NO and wherein, when there is more than one substituent, said substituent is the same or different, R in which p is 0 or 1 and, when p is 1, (CH group a, in which group a consists of: halogen atoms; hydroxyl; trifluoromethyl; linear and branched alkyl, alkenyl, alkynyl, and alkoxyl groups, all optionally further substituted by one or more of hydroxy groups, halogen atoms, alkoxy groups, amino groups, and alkylthio groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; aryl groups; aralkyl groups; aralkoxy groups; aryloxy groups; perfluoroalkyl; perfluoroalkoxy; —CN; the groups —NR Alk is an alkyl group, and R 4 and R 5 are the same or different and are H, alkyl, aralkyl, aryl, heteroaryl or heteroaralkyl and are optionally further substituted by one or more substituents selected from trifluoromethyl, halogen atoms and hydroxyl groups; the groups —NZC(═X)(NH) in which Z is H or C(═X)R 6 wherein each X and each R 6 is the same or different, q is 0 or 1 and, when q is 1, (NH) q is optionally substituted with a methyl, ethyl, or trifluoromethyl group, X is oxygen or sulfur, Alk is an alkyl group, and R 6 is H, OH, alkyl, aralkyl, aryl, heteroaryl or heteroaralkyl and is optionally further substituted by one or more substituents selected from trifluoromethyl, halogen atoms and hydroxyl groups or, when C(═X) is CO, then C(═X)R 6 may form an ester or thioester grouping; the groups —NHSO in which R 7 is OH or amino, or R 7 is alkyl, aralkyl, alkylamino, aralkylamino, aryl, heteroaryl or heteroaralkyl, optionally further substituted by one or more substituents selected from trifluoromethyl, halogen atoms and hydroxyl groups; and saturated or unsaturated heterocyclyl groups, said heterocyclyl groups being mono- or bi-cyclic and being optionally substituted by one or more substituents, which may be the same or different, selected from the group b, wherein the group b consists of: halogen atoms; hydroxyl; carboxyl; aldehyde groups; linear and branched alkyl, alkenyl, alkynyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, haloalkyl, haloalkenyl, and haloalkynyl groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; alkoxycarbonyl; hydroxycarbonylalkyl; alkoxycarbonylalkyl; perfluoroalkyl; perfluoroalkoxy; —CN; acyl; amino, alkylamino, dialkylamino, acylamino, and diacylamino groups; alkyl groups substituted with an amino, alkylamino, dialkylamino, acylamino, or diacylamino group; CONH wherein, in groups a and b, any alkyl components contain from 1 to 6 carbon atoms, and any alkenyl or alkynyl components contain from 2 to 6 carbon atoms, and are optionally substituted by at least one halogen atom or hydroxy group, and wherein any aryl component is optionally a heteroaryl group, and when n is at least two, then two adjacent groups R may form a 5, 6, or 7 membered fused carbocyclic or heterocyclic ring with Ar, said fused ring being optionally further substituted with an oxo group or a substituent selected from group b as defined above, provided that, when p is 0, then Ar is not thiazolyl or oxazolyl, either unfused or fused with a monocyclic aryl or a monocyclic heteroaryl, and salts and esters thereof.