Patent ID: 7198955
Filing Date: 2007-04-03
Classification: G01N,Y10T

Abstract:
1. A method of determining a corrected concentration of an analyte contained in a specimen comprising a blood substitute interferent and a non-blood substitute interferent, said method comprising the steps of: i) providing a first calibration algorithm for said blood substitute interferent, a second calibration algorithm for said non-blood substitute interferent, a first linear equation defining a relationship between a measured concentration of said analyte and a concentration of said blood substitute interferent, and a second linear equation defining a relationship between a measured concentration of said analyte and a concentration of said non-blood substitute interferent, said first and second calibration algorithms developed using a calibration set comprising variable amounts of said blood substitute interferent and said non-blood substitute interferent; ii) measuring an absorbance or reflectance of radiation of said specimen in a tube or a pipette tip, wherein said measuring is performed in the absence of any reaction step that generates a chromophore within said specimen; iii) using said first and second calibration algorithms and said absorbance or reflectance measured in step (ii) to calculate a concentration of said blood substitute interferent and a concentration of said non-blood substitute interferent in said specimen; followed by iv) determining an initial concentration of said analyte in said specimen disposed within an analysis slide with a slide analyzer, and v) using said first and second linear equations from step (i), said concentrations from step (iii), and said initial concentration from step (iv), to determine said corrected concentration of said analyte.