Patent ID: 6894162
Filing Date: 2005-05-17
Classification: A61P,C07D

Abstract:
1. A process for the production of cefuroxime sodium salt or cefuroxime axetil said process comprising the following steps: A) acylating 7-amino-3-hydroxymethyl-3-cephem-4-carboxylic acid in the form of a amidine salt selected from the group consisting of tetramethyl guanidine, 1,8-diazabicyclo[5.4.0] undec-7-ene and 1,5diazabicyclo[4.3.0]non-5-ene with a reactive derivative of (Z)-2-furyl-2-methoxyimino-acetic acid to obtain 7-[(Z)-2-furyl-2-methoxyiminioacetamide]-3-hydroxymethyl-3-cephem-4-carboxylic acid; B) reacting 7-[(Z)-2-furyl-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid with a carbamoylation agent to obtain cefuroxime; C) isolating cefuroxime in the form of a salt with n-butylamine; and either D1) reacting cefuroxime in the form of a salt with n-butylamine in the presence of a source of sodium; and isolating cefuroxime in the form of a sodium salt from the reaction mixture; or D2) reacting cefuroxime in the form of a salt with n-butylamine with 1-acetoxyethyl bromide in the presence of a base and isolating cefuroxime axetil from the reaction mixture.