Patent ID: 8278281
Filing Date: 2012-10-02
Classification: A61P,C07H

Abstract:
1. A compound having the structure: or a pharmaceutically acceptable salt, ester, or N-oxide thereof, wherein A is selected from: (a) a C wherein (a)-(e) optionally are substituted with one or more R 14 groups; T is a 14- or 15-membered macrolide connected via a macrocyclic ring carbon atom; X is selected from —OR R alternatively, R R R alternatively, NR R R alternatively, NR alternatively, CR R R R R R R R R alternatively, two R R n at each occurrence is 0, 1, 2, 3, or 4; p at each occurrence is 0, 1, or 2; r at each occurrence is 0, 1, or 2; t at each occurrence is 0, 1, or 2; and u at each occurrence is 1, 2, 3, or 4.