Patent ID: 6156339
Filing Date: 2000-12-05
Classification: A61K,A61P

Abstract:
A process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises:(i) forming a solution or a suspension in a solvent of a water soluble or water dispersible carrier, a filler, the pharmaceutically active substance with the unacceptable taste and a lipid wherein the pharmaceutically active substance forms an association in situ with the lipid, the weight ratio of the pharmaceutically active substance to the lipid being in the range of from 1:1 to 1:10 and the weight ratio of the carrier to the lipid being in the range of from 5:1 to 1:15;(ii) forming discrete units of the suspension or solution; and(iii) removing the solvent from the discrete units under conditions whereby unit dosages are formed comprising a network of carrier/filler carrying a dosage of the pharmaceutically active substance in association with the lipid.