Patent ID: 6579890
Filing Date: 2003-06-17
Classification: A61P,C07C,C07D,C07F

Abstract:
A compound of the formula: wherein:R1 is mercapto, carboxy, or a group of the formula: â€ƒwhere R6 is optionally substituted aryl or heteroaryl; R2 is alkyl, optionally substituted phenyl, or a group of the formula: â€ƒwherein: A is CH2, O, NH, S, CH2â€”CH2, or NHâ€”CH2; R10 is H, alkyl, alkoxy, alkylamino or acylamide; and R11 is H or halo; R7 is 4-pyridyl and p is 0; R3 is alkyl, cycloalkyl, aralkyl, or heteroaralkyl, where the aralkyl and heteroaryl groups may be optionally substituted and where the alkyl is optionally substituted by cycloalkyl, hydroxy, mercapto, alkylthio, aralkoxy, amino, mono- and diallkylamino, guanidino, N,N-dialkylguanidino, carbamoyl, aryl or heteroaryl; X is a group of the formula â€”(CH2)mâ€”Yâ€”(CH2)nâ€”, where: Y is O, S, or a single bond, m is an integer from 0 to 4, n is an integer from 0 to 4, and m+n is an integer from 0 to 4; p is an integer from 0 to 4, provided that R2â€”X is biphenylalkyl when p is not 0; or a pharmaceutically acceptable salt thereof.