Patent ID: 8241609
Filing Date: 2012-08-14
Classification: A61L

Abstract:
1. A method for embolization of vasculature in a mammal comprising the steps of: a) providing (i) a first aqueous solution or dispersion comprising at least one oxidized polysaccharide containing aldehyde groups, having a weight-average molecular weight of about 3,000 to about 250,000 Daltons, said at least one oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons, said solution or dispersion containing about 5% to about 40% by weight of said at least one oxidized polysaccharide; b) providing (ii) a second aqueous solution or dispersion comprising at least one water-dispersible, multi-arm amine selected from the group consisting of a water dispersible multi-arm polyether amine, an amino-terminated dendritic polyamidoamine, and a multi-arm branched end amine, wherein at least three of the arms are terminated by a primary amine group, wherein said at least one multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons, said solution or dispersion containing about 5% to about 70% by weight of said at least one multi-arm amine; or c) mixing (i) and (ii) or (i) and (iii) to form a mixture; and d) introducing said mixture into the vasculature of the mammal before said mixture completely cures;