Patent ID: 6353010
Filing Date: 2002-03-05
Classification: A61P,C07D

Abstract:
A compound of the general formula (i) whereinX is N; Z is &boxH;CR1â€” and Y is O or S; Q is selected from the group consisting of O and S; R1 is selected from the group consisting of COR6, C(&boxH;NOR6)R13, alkyl-C(&boxH;NOR6)R13, NR8R9, CON(R6)2, halogen, CF3, CN, CO2H, CO2R10, R6, CO-het where het is a heterocyclic ring attached via a N atom in the ring and optionally substituted with one or more R14, or the cyclic group â€ƒR3 is selected from the group consisting of OH, thioalkyl, and C1-6 alkoxy or cycloalkoxy each optionally substituted with one or more halogens; R4 is selected from the group consisting of H and alkyl; R5 is aryl or heteroaryl, (or N-oxides thereof) either of which may be optionally substituted with one or more substituents selected from the group consisting of halogen, optionally halogen-substituted alkyl, hydroxy, optionally halogen-substituted alkoxy, CO2H, CO2R10, CONR11R12, COR10, SO2R10, SO2NR11R12, NR8R9, and CN; each R6 is independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl, and heterocycloalkyl, any of which groups is optionally substituted at any position with R7; R7 is selected from the group consisting of alkyl, hydroxy, OR10, NR8R9, CN, CO2H, CO2R10, CONR11R12, and COR10; R8 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl, heterocycloalkyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl, alkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, and heterocyclosulphonyl; R9 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, aralkyl, heteroarylalkyl, and heterocycloalkyl; or NR8R9 is a heterocyclic ring optionally substituted with R14; R10 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl, and heterocycloalkyl; R11 and R12 are the same or different and are each H or R10; R13 is R10 optionally substituted with one or more R7; R14 is selected from the group consisting of alkyl, arylalkyl, and heteroarylalkyl; and R15 is alkyl; V is O or S, and n=2-4; or a pharmaceutically-acceptable salt thereof.