Patent ID: 6166016
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
An amide compound represented by the formula, ##STR190## wherein ring A represents a benzene ring or a naphthalene ring; when ring A is a naphthalene ring, R.sup.1, R.sup.2 and R.sup.3 are all hydrogen atoms, and when ring A is a benzene ring, R.sup.1, R.sup.2 and R.sup.3 are the same or different and independently represent hydrogen, lower alkoxy, halogen, nitro, lower alkyl, halogen-substituted lower alkyl, phenyl, phenoxy, lower alkanoyloxy, hydroxy, lower alkylthio, lower alkyl sulfinyl or lower alkyl sulfonyl;R.sup.4 represents a heterocyclic group selected from the group consisting of (1) a lower alkyl-substituted thieno[3,2-d]-pyrimidin-4-yl group, (2) a pyrazolo [1,5-a]-1,3,5-triazin-4-yl group optionally having one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl(lower)alkyl, phenylthiophenyl and halogen, (3) a pyrazolo[3,4-d]pyrimidin-4-yl group which has a lower alkyl group at the 6-position and one of those nitrogen atoms may have a phenyl(lower) alkyl group as a substituent, and (4) a purin-6-yl group which has a lower alkyl group at the 2-position and one of whose nitrogen atoms may have a lower alkyl or phenyl (lower) group as a substituent; andR.sup.5 represents a hydrogen atom or a group represented by ##STR191## wherein A, R.sup.1, R.sup.2 and R.sup.3 are as defined above.