Patent ID: 7759526
Filing Date: 2010-07-20
Classification: A61K,A61P,C07C

Abstract:
1. A process for the preparation of a compound-having general Formula I, wherein R′ is CH 2 OH and R″ is selected from the group consisting of: a. a straight or branched alkyl of 5 to 12 carbon atoms; b. a group —O—R′″, where R′″ is a straight or branched alkyl of 5 to 9 carbon atoms, or a straight or branched alkyl substituted at the terminal carbon atom by a phenyl group; and c. a group —(CH the process comprising: (a) blocking the phenolic groups of the following compound wherein R″ is selected from the group above; (b) selective epoxidation of the ring double bond of the compound obtained in step (a); (c) selective opening of the epoxide ring of the compound obtained in step (b) to form the corresponding allylic alcohol; (d) performing an allylic rearrangement of the compound obtained in step (c) to obtain the following compound (e) demethoxylating the compound obtained in step (d) to thereby prepare the compound of general formula I.