Patent ID: 8518376
Filing Date: 2013-08-27
Classification: A61K,A61P

Abstract:
1. A waterless foamable pharmaceutical composition, comprising a foamable carrier, a tetracycline antibiotic, and at least one liquefied or compressed gas propellant wherein the foamable carrier comprises: about 60% to about 98% by weight a liquid oil comprising a mixture of a mineral oil and one or more liquid oils selected from the group consisting of a medium chain triglyceride oil, a liquid paraffin, a vegetable oil, an essential oil and a silicone oil; and about 2% to about 40% by weight of a first surfactant, wherein the surfactant comprises a glycerol fatty acid ester having a C 8 -C 24 saturated hydrocarbon chain; and optionally an additive selected from the group consisting of a foam adjuvant, a polymer stabilizer, a thickener, a phospholipid and mixtures of any two or more thereof, wherein the foamable carrier has compatibility with the tetracycline antibiotic such that the tetracycline antibiotic is chemically stable for at least 72 hours at 25° C. in the presence of the foamable carrier; and wherein the foamable carrier is substantially a single phase, is in a compatible canister and wherein upon dispensing the foamable composition forms a breakable foam that is thermally stable at 36° C., yet breaks upon application of shear force.