Patent ID: 8858984
Filing Date: 2014-10-14
Classification: A61J,A61K,A61P

Abstract:
1. A method of making a glassy lozenge comprising a non-crystalline matrix having a hydrogel structure, an active agent and water for buccal drug delivery comprising the steps: a) mixing a gum, one or more non-crystallising sugars or non-crystallising sugar alcohols and water; b) heating the mixture with mixing; c) adding an active agent and mixing; and d) moulding the mixture to form lozenges; wherein the matrix comprises (i) at least one gum and (ii) at least one non-crystallising sugar or non-crystallising sugar alcohol; wherein the matrix comprises, by weight, from 40-90% of gum component (i), and from 60-10% of the non-crystallising sugar or non-crystallising sugar alcohol component (ii); wherein the lozenge dissolves or disintegrates gradually; wherein the active agent is selected from an anti-emetic agent, an agent for migraine treatment, and an analgesic agent; and wherein step (b) comprises heating the mixture to at least 90° C.