Patent ID: 6696437
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound of the formula I or II in whichA is naphthalene, a monocyclic aromatic, bicyclic and tricyclic aromatic or partly aromatic heterocyclic system comprising a maximum of 15 carbon atoms and up to 4 beteroatoms selected from the group of N,O,S, and rings may additionally carry up to 2 oxo groups, and A may also be substituted by up to three different or identical R3 radicals and additionally one R4 radical, and R1 is hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6-alkyl, OH, nitro, CF3, CN, NR11R12, NHâ€”COâ€”R13, Oâ€”C1-C4-alkyl, where R11 and R12 are, independently of one another, hydrogen or C1-C4-alkyl, and R13 is hydrogen, C1-C4-alkyl, phenyl-C1-C4-alkyl or phenyl, and R2 is hydrogen, branched and unbranched C1-C6-alkyl and R3 is hydrogen, chlorine, bromine, iodine, fluorine, CF3, OCF3, nitro, NH2, COâ€”R8, CO2â€”R8, SO2â€”R8, OH, Oâ€”C1-C4-alkyl, phenyl-C0-C4-alkyl-Oâ€”, a C1-C6 chain which may be saturated, unsaturated or partially unsaturated and may also be substituted by an R33 radical, phenyl, where the phenyl rings may also be substituted by up to three identical or different R31 radicals, and pyridyl which may be substituted by up to three R32 radicals, and R31 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NH2, and R32 is OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NH2, CN, and R33 is COâ€”NHâ€”R8, OH, Oâ€”C1-C6-Alkyl, Oâ€”COâ€”R8, and R4 is hydrogen and â€”(D)pâ€”(E)sâ€”(CH2)qâ€”B, where D is S, NR43and 0 E is phenyl and s is 0 and 1 and B is NR41R42 and andp can be 0 and 1, and q can be 0, 1, 2, 3 or 4, and R41 can be hydrogen, C1-C6-alkyl, (CH2)râ€”G, and R42 can be hydrogen, C1-C6-alkyl, â€”COâ€”R8, SO2â€”R8, CO2â€”R8, â€”(C&boxH;NH)â€”R8 and â€”(C&boxH;NH) â€”NHR8 and R41 and R42 can form a phthaloyl radical and R43 can be hydrogen and C1-C4-alkyl and r can be 0,1,2,3,4 and G can be phenyl, which may also carry a maximum of two radicals NR11R12, phenyl-C1-C4-alkyl-NH, pyrrolidine, piperidine, 1,2,5,6-tetrahydropyridine, morpholine, homopiperidine, piperazine, which may also be substituted by an alkyl radical C1-C6-alkyl, and homopiperazine, which may also be substituted by an alkyl radical C1-C6-alkyl, and R7 can be hydrogen, C1-C6-alkyl, phenyl, it also being possible for the ring to be substituted by up to two R71 radicals, and R71 can be OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NH2, and R8 can be C1-C6-alkyl, CF3, NR11R12, phenyl, phenyl-C1-C4-alkyl, it also being possible for the ring to be substituted by up to two R81 radicals, and R81 can be OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NH2, and R9 can be hydrogen, COâ€”R8, SO2â€”R8, CO2â€”R8, C1-C6-alkyl, phenyl-C1-C4-alkyl and phenyl, it being possible for the phenyl rings also to be substituted by up to two R91 radicals, and R91 can be OH, C1-C6-alkyl, Oâ€”C1-C4-alkyl, chlorine, bromine, iodine, fluorine, CF3, nitro, NH2, and its tautomeric forms, possible enantiomeric and diastereomeric forms, and its phosphate, carbamate of amino acid or ester prodrugs.