Patent ID: 6432640
Filing Date: 2002-08-13
Classification: C12Q

Abstract:
A method of screening for cancer or p53 status in a sample suspected of being neoplastic, comprising the steps of:comparing the level of transcription of an RNA transcript in a first sample of a first tissue to the level of transcription of the transcript in a second sample of a second tissue, wherein the first tissue is a human tissue suspected of being neoplastic and the second tissue is a normal human tissue, wherein the first and second tissue are of the same tissue type, and wherein the transcript is identified by a nucleic acid consisting of a tag set forth as SEQ ID NO:19, and wherein the tag is located 3â€² of the 3â€²-most site for a NlaIII restriction endonuclease in a cDNA reverse transcribed from the transcript; categorizing the first sample as likely to be neoplastic or likely to have a mutant p53 when transcription is found to be the same or lower in the first sample than in the second sample.