Patent ID: 6753323
Filing Date: 2004-06-22
Classification: A61K,A61P

Abstract:
A method of protecting mucosal tissue in the head and/or neck region of a human in need thereof from mucositis and the symptoms thereof, which comprises topically administering to the mucosal tissue of the human a therapeutically effective amount of at least one compound having the formulaR1NH(CH2)nNH(CH2)mSR2 wherein R1 is hydrogen, C5-C7 aryl, C2-C7 acyl, or C1-C7 alkyl; R2 is hydrogen, PO3H2 or R3, wherein R3 is R1NH(CH2)nNH(CH2)mSâ€”; n is an integer from 1 to 10; and m is an integer from 1 to 10, or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the mucositis is induced by treatment with radiation and/or chemotherapeutic agents.