Patent ID: 6476065
Filing Date: 2002-11-05
Classification: A61K,C07D

Abstract:
A method for inhibiting the growth of cancer cells, said method comprising administering to said cells an effective amount of a compound having one of the following structures, or an analog thereof: whereinR1=OX, where X=â€”A, â€”CH2â€”Q, â€”COA or â€”COZ R2=OA A=lower alkyl Q=phenyl, tolyl or xylyl Z=monocyclic aryl; or â€ƒwherein R1=OX, where X=â€”A, â€”CH2â€”Q, â€”COA or â€”COZ R2=OA A=lower alkyl Q=phenyl, tolyl or xylyl Z=monocyclic aryl; or â€ƒ&Dgr;4-28 or &Dgr;18 or &Dgr;21 or &Dgr;23 â€ƒwherein R1=OX, where X=â€”A, â€”CH2â€”Q, â€”COA or â€”COZ R2=OA A=lower alkyl Q=phenyl, tolyl or xylyl Z=monocyclic aryl; or â€ƒ&Dgr;4-28 and &Dgr;18 or &Dgr;4-28 and &Dgr;21 or &Dgr;4-28 and &Dgr;23 &Dgr;18 and &Dgr;21 or &Dgr;18 and &Dgr;23 or &Dgr;21 and &Dgr;23 â€ƒwherein R1=OX, where X=â€”A, â€”CH2â€”Q, â€”COA or â€”COZ R2=OA A=lower alkyl Q=phenyl, tolyl or xylyl Z=monocyclic aryl; or â€ƒ&Dgr;4-28, &Dgr;18, &Dgr;21 or &Dgr;4-28, &Dgr;18, &Dgr;23 or &Dgr;4-28, &Dgr;21, &Dgr;23 or &Dgr;18, &Dgr;21, &Dgr;23 â€ƒwherein R1=OX, where X=â€”A, â€”CH2â€”Q, â€”COA or â€”COZ R2=OA A=lower alkyl Q=phenyl, tolyl or xylyl Z=monocylic aryl.