Patent ID: 6242461
Filing Date: 2001-06-05
Classification: A61K,A61P

Abstract:
The method of inhibiting the enzymatic functions of HIV-reverse transcriptase in a patient which comprises administering to a patient infected with HIV-reverse transcriptase a therapeutically effective amount of the compound of Formula I or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. ##STR3##n is an integer from 1 to 4X is CHI or N;R.sup.1 is H, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6) alkoxy;R.sup.2 is H, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6) alkoxy;each R.sup.3 is independently selected from H, (C.sub.1 -C.sub.6)alkyl (C.sub.1 -C.sub.6) alkyloxy, (C.sub.1 -C.sub.6) alkylthio,halo, nitro, cyano, ethynyl, hydroxy and trifluoromethyl; andR.sup.4 is H, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6) alkoxy;R.sup.5 is H, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6) alkyloxy, trifluoromethyl; andW is N or C;Y is N(R.sup.4), N, S or OZ is R.sup.4, NR.sup.4 H, O, or OH;provided that when Y.dbd.NR.sup.4, W.dbd.C, Z.dbd.O, there is a single bond between YW and a double bond between WZ;when Y.dbd.O or S, W.dbd.C, Z.dbd.O, there is a single bond between YW and a double bond between WZ;when Y.dbd.N, W.dbd.C, Z.dbd.R.sup.4 or NHR.sup.4, there is a double bond between YW and a single bond between WZ; andwhen Y.dbd.N, W.dbd.N, there is a double bond between YW and Z does not exist.