Patent ID: 6824759
Filing Date: 2004-11-30
Classification: A61K

Abstract:
A method for imaging tumors in a mammal, said method comprising:(a) injecting into said mammal in need of such imaging an effective diagnostic amount of a composition comprising a pharmaceutical carrier and a compound having formula I or II: M-Z-X1â€”Pâ€”X2â€ƒâ€ƒ(I) X1â€”Pâ€”X2-Z-Mâ€ƒâ€ƒ(II) wherein: M is a four-amino acid radiolabeling moiety complexed to a radionuclide in an N4 configuration; Z is 4-aminobutyric acid; X1 is from zero to twenty natural or synthetic amino acids; P is a peptide having the amino acid sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (SEQ ID NO: 1), or an analog or fragment thereof, wherein said analog or fragment retains the biological activity of SEQ.ID.NO: 1; and X2 is from zero to twenty natural or synthetic amino acids; and (b) scanning said mammal using radioscintigraphic imaging apparatus to image tumors in said mammal.