Patent ID: 6699716
Filing Date: 2004-03-02
Classification: A61K,A61P,C12N

Abstract:
A method for increasing detoxification enzyme activity of one or more hepatocyte isolated from a donor liver, comprising:administering at least one induction agent to a non-human donor in an amount sufficient to increase detoxification enzyme activity of one or more hepatocyte, isolating the hepatocyte from the donor liver, incorporating the isolated hepatocyte in a bioreactor, wherein the induction agent is selected from the group consisting of: beta-naphthoflavone, phenobarbital, 3-methylcholanthrene, ethanol, dexamethasone, arochlor 1254, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenothiazine, chlorpromazine, isosafole, &ggr;-chlordane, allylisopropylacetamide, trans-stilbene oxide, kepone, acetone, isoniazid, pyridine, pyrazole, 4-methylpyrazole, pregnenolone 16&agr;-carbonitrile, troleandomycin, clotrimazole, clofibrate, clobuzarit, di(2-ethylhexyl)phthalate, and mono-(2-ethylhexyl)phthalate.