Patent ID: 8961965
Filing Date: 2015-02-24
Classification: A61P,G01N,G16H

Abstract:
1. A method of treating a patient having asthma comprising: (a) measuring a white blood cell count in a sample taken from a patient having eosinophilic asthma to calculate a white blood cell ratio, wherein the white blood cell count comprises an eosinophil count, a neutrophil count, a lymphocyte count, an eosinophil precursor count, a basophil precursor count, or any combination thereof and wherein the white blood cell ratio is a ratio between an eosinophil count and a second white blood cell type count; (b) calculating a diagnostic score from the white blood cell ratio, wherein the diagnostic score indicates whether the patient has eosinophilic asthma, and wherein the diagnostic score is the variance between two intermediate scores (Score 1 and Score 2), wherein Score 1 is calculated according to the formula: and Score 2 is calculated according to the formula: wherein: (i) a is −9.5243233; (ii) b is 70.0974823; (iii) c is 3.7789926; (iv) d is −14.5853365; (v) e is 101.2197561; and, (vi) f is 3.9567050, wherein a Score 1≦Score 2 indicates that the patient has eosinophilic asthma; and, (c) administering an effective amount of an anti-IL5R antibody to the patient if the patient has eosinophilic asthma.