Patent ID: 6140362
Filing Date: 2000-10-31
Classification: A61K,A61P

Abstract:
A method for inhibiting mammalian cell growth in benign or malignant tumors comprising treating said cells with an effective amount of a compound having the structural formula: ##STR14## R.sup.1 and R.sup.2 are selected from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, and (C.sub.2 -C.sub.6)alkynyl, provided that at least one of R.sup.1 and R.sup.2 is not H; R.sup.3, R.sup.4, and R.sup.5 are each independently selected from the group consisting of H, halo, cyano, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkoxyl, (C.sub.1 -C.sub.6)alkylthio, halo(C.sub.1 -C.sub.6)alkoxyl, nitro, --NR.sup.6 R.sup.7, --CR.sup.8 .dbd.NOR.sup.9, NHCOOR.sup.10, --CONR.sup.11 R.sup.12, and --COOR.sup.13, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, and R.sup.13 are H or (C.sub.1 -C.sub.6)alkyl; and X and Y are each independently selected from the group consisting of H, halo, cyano, thiocyano, isothiocyano and (C.sub.1 -C.sub.6)alkylsulfonyloxy, provided that at least one of X and Y is halo, cyano, thiocyano, isothiocyano or (C.sub.1 -C.sub.6)alkylsulfonyloxy and wherein said cells are sensitive to the compounds of the formula.