Patent ID: 8236531
Filing Date: 2012-08-07
Classification: C12N,C12P

Abstract:
1. A method for producing a purine-derived substance, which comprises (A) culturing a bacterium belonging to the genus (B) collecting the purine-derived substance from the bacterium or medium, wherein the bacterium has been modified to decrease the enzymatic activity of transaldolase by disrupting a gene encoding transaldolase, or decreasing the expression of the gene encoding transaldolase, wherein the gene transaldolase is selected from the group consisting of: (A) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO: 2, and (B) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO: 2, but which includes substitutions, deletions, insertions, or additions of one to 10 amino acid residues and has transaldolase activity, wherein said bacterium has been further modified to decrease fructose bisphosphatase activity as compared to an unmodified strain by disrupting a gene encoding fructose bisphosphatase, or decreasing the expression of the gene encoding fructose bisphosphatase.