Patent ID: 6288234
Filing Date: 2001-09-11
Classification: A61K,A61P,C07C,C07D,C07H,C12Q,C40B,G01N,Y02A,Y10S

Abstract:
A compound of formula II:L'--X'--L' IIwherein each L' is a ligand independently selected from the group consisting of: ##STR475##whereineach R.sup.20 and R.sup.21 is independently selected from the group consisting of hydrogen and halo;each R.sup.22 is independently selected from the group consisting of hydrogen, alkyl and halo;each R.sup.23 is independently selected from the group consisting of hydrogen and a covalent bond linking the ligand to the linker;each R.sup.24 is independently selected from the group consisting of hydrogen and a covalent bond linking the ligand to the linker;each R.sup.25 is independently selected from the group consisting of aryl, heteroaryl, heterocyclic, cycloalkyl, substituted cycloalkyl and a covalent bond linking the ligand to the linker;each R.sup.26 is independently selected from the group consisting of hydrogen, alkyl and a covalent bond linking the ligand to the linker;each Q"" is independently selected from the group consisting of a covalent bond, --O-- and --S--;each a is independently an integer of from 2 to 6;X' is a linker represented by the formula:--X.sup.a --Z--(Y.sup.a --Z).sub.m --Y.sup.b --Z--X.sup.a --whereinm is an integer of from 0 to 20;X.sup.a at each separate occurrence is selected from the group consisting of --O--, --S--, --NR--, --C(O)--, --C(O)O--, --C(O)NR--, --C(S), --C(S)O--, --C(S)NR-- or a covalent bond where R is as defined below;Z is at each separate occurrence is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cylcoalkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, cycloalkenylene, substituted cycloalkenylene, arylene, heteroarylene, heterocyclene, or a covalent bond;Y.sup.a and Y.sup.b at each separate occurrence are selected from the group consisting of --C(O)NR'--, --NR'C(O)--, --NR'C(O)NR', --C(.dbd.NR')--NR', --NR'--C(.dbd.NR')--, --NR'--C(O)--O--, --N.dbd.C(X.sup.a)--NR'--, --P(O)(OR')--O--, --S(O).sub.n CR'R""--, --S(O).sub.n --NR'--, --S--S-- and a covalent bond; where n is 0, 1 or 2; andR, R' and R"" at each separate occurrence are selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl and heterocyclic;and pharmaceutically-acceptable salts or pro-drugs thereof;provided that in each ligand only one of R.sup.23, R.sup.24, R.sup.25 and R.sup.26 is a covalent bond linking the ligand to the linker.