Patent ID: 6127395
Filing Date: 2000-10-03
Classification: C07D

Abstract:
A compound of the formula: ##STR50## or a pharmaceutically acceptable non-toxic salt thereof wherein:T is NH, O, or SX is hydrogen, hydroxyl, lower alkyl, or CONR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 independently representhydrogen or lower alkyl; ##STR51## represents benzo, thieno, or pyrido, each of which is optionally mono or disubstuted with halogen, hydroxyl, lower alkyl, amino, mono- or dialkylamino where each alkyl is lower alkyl, or lower alkoxy; and ##STR52## represents ##STR53## wherein: n is 0,1,2,or 3;R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, phenyl, or 2-, 3-, or 4- pyridyl;or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl, each of which is mono or disubstituted with halogen, hydroxyl, lower alkyl or alkoxy lower alkyl; andR.sub.7, R.sub.8, R.sub.9, and R.sub.10 independently represent hydrogen, or lower alkyl;or R.sub.7 and R.sub.8 together represent a group of the formula ##STR54## where n is 0, 1, or 2; with the proviso that, when T is NH or S, at least one of ##STR55## is substituted.