Patent ID: 6747044
Filing Date: 2004-06-08
Classification: C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt thereof,whereinR1 denotes 1,3-dihydroxyprop-2-yl, R2 denotes hydrogen, C1-C6alkyl, &ohgr;-hydroxy-C2-C4-alkyl, 1,3-dihydroxyprop-2-yl or C3-C6-cycloalkylmethyl, Ar denotes unsubstituted phenyl or phenyl which is 1- to 5-substituted by halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, C1-C4-fluoroalkoxy or â€”OCH2Oâ€”; R3 denotes phenyl-C1-C4-alkyl, wherein the phenyl group may be substituted by 1 to 3 substituents, wherein the substituents independently of one another are selected from halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl, and C1-C4-fluoroalkoxy; and R4 denotes hydrogen, C1-C4-alkyl, C3-C8-cycloalkyl, CH2COOH, â€”CH2C(O)NH2, â€”OH or phenyl-C1-C4-alkyl.