Patent ID: 6107282
Filing Date: 2000-08-22
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition useful to bind C. difficile toxin B in a subject, which composition comprises:a) at least one oligosaccharide sequence covalently attached to a pharmaceutically acceptable inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds toxin B; andb) a pharmaceutically acceptable carrier, wherein said composition is capable of being eliminated from the gastrointestinal tract, and wherein said oligosaccharide sequence is .alpha.Glc(1-6).alpha.Glc(1-6).beta.Glc and said linker arm is --NH--(CH.sub.2).sub.m --NHC(O)NH--, where m is an integer of from about 2 to about 10.