Patent ID: 6465651
Filing Date: 2002-10-15
Classification: A61P,C07D,Y02P

Abstract:
A process for preparing a compound of Formula III, whereinPt is tert-butyloxycarbonyl;R2 is hydrogen, (C1-C8)alkyl or â€”(C0-C3)alkyl-(C3-C8)cycloalkyl; where the alkyl groups andthe cycloalkyl groups in the definition of R2 are optionally substituted with 1, 2 or 3 fluorine;comprising reacting a compound of Formula IV, wherein R3 is (C1-C4)alkyl and Pt is as defined above,with a preformed isocyanate or a carbonyl equivalent and R2NH2, wherein R2 is as defined hereinabove, in a reaction inert solvent for about one hour to about 72 hours at a temperature of about 0Â° C. to about 80Â° C.