Patent ID: 6656499
Filing Date: 2003-12-02
Classification: A61K

Abstract:
An interferon-&agr; composition, comprisingbiphasic lipid vesicles comprised of (i) a lipid bilayer comprising a phospholipid and a fatty acylated amino acid; (ii) an oil-in-water emulsion entrapped in the biphasic lipid vesicles, said oil-in-water emulsion being stabilized by a surfactant; and (iii) interferon-&agr; entrapped in said vesicles; said fatty acylated amino acid being represented by the formula: wherein R1 is an acyl group having from 1-20 carbons, R2 is hydrogen or an alkyl group, and R3 corresponds to a modified or unmodified R group of an amino acid selected from the group consisting of glycine, alanine, serine, aspartic acid, arginine, valine, threonine, glutamic acid, leucine, cysteine, histidine, lsoleucine, tyrosine, asparagine, methionine, proline, tryptophan, phenylalanine, and glutamine; wherein said composition when applied to the skin of a subject being effective to administer a therapeutically effective amount of interferon-&agr;.