Patent ID: 7091339
Filing Date: 2006-08-15
Classification: C07D

Abstract:
1. A method of preparing a 5H-dibenz[b,f]azepine-5-carboxamide of formula (1) wherein R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, halogen, nitro, cyano, carboxyl, A, —CO(A), —OCO(A), —O(A), —N(A) 2 , —CON(A) 2 , and —COO(A), wherein A is selected from the group consisting of C 1 –C 10 alkyl, C 3 –C 10 cycloalkyl, C 2 –C 10 alkenyl, C 5 –C 10 cycloalkenyl, C 2 –C 10 alkynyl, and C 6 –C 20 aryl, wherein the two A groups of —N(A) 2 and —CON(A) 2 can be the same or different, and wherein R 2 and R 3 can together form a bond; comprising reacting a 5H-dibenz[b,f]azepine of formula (2) with: (a) a cyanate salt selected from the group consisting of alkali metal cyanate salts and alkaline-earth metal cyanate salts, and (b) a salt of an amino compound having no N—H bonds, wherein the salt has a K