Patent ID: 6323366
Filing Date: 2001-11-27
Classification: C07C

Abstract:
The method depicted in Scheme 1: ##STR70##wherein:Ar is selected from the group consisting of optionally substituted monocyclic and polycyclic aromatic and heteroaromatic moieties;X is selected from the group consisting of Cl, Br, I, --OS(O).sub.2 halogen, --OS(O).sub.2 alkyl, and --OS(O).sub.2 aryl;the transition metal catalyst comprises a transition metal selected from Groups 5-12 of the periodic table;R is selected from the group consisting of hydrogen, trialkylstannyl, triarylstannyl, trialkylsilyl, triarylsilyl, lithium, sodium, potassium, magnesium halide, calcium halide, --B(OH).sub.2, and groups that are replaced by hydrogen under the reaction conditions;R.sub.1 and R.sub.2, each independently represent hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl group, or --(CH.sub.2).sub.m --R.sub.8 ; or R.sub.1 and R.sub.2 taken together form an optionally substituted ring;the base is selected from the group consisting of alkoxides, carbonates, amides, phosphates, fluorides;R.sub.8 represents an optionally substituted aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle; andm is an integer in the range of 0 to 8 inclusive.