Patent ID: 6177440
Filing Date: 2001-01-23
Classification: C07D

Abstract:
A compound of the formula (I) ##STR206##wherein;A is phenyl or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position;B is nitrogen and D is carbon;Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-, 2-, or 3-position, or a 6-membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2- or 3-position, and nitrogen at the 1-, 2-, 3- or 4-position; ##STR207##is a double or single bond;R.sup.20 is selected from groups (a), (b) and (c) where;(a) is --(C.sub.5 -C.sub.20)alkyl, --(C.sub.5 -C.sub.20)alkenyl, --(C.sub.5 -C.sub.20)alkynyl, carbocyclic radicals, or heterocyclic radicals, or(b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or(c) is the group --(L)--R.sup.80 ; where, --(L)-- is a divalent linking group of 1 to 12 atoms selected from carbon, hydrogen, oxygen, nitrogen, and sulfur; wherein the combination of atoms in --(L)-- are selected from the group consisting of (i) carbon and hydrogen only, (ii) one sulfur only, (iii) one oxygen only, (iv) one or two nitrogen and hydrogen only, (v) carbon, hydrogen, and one sulfur only, and (vi) and carbon, hydrogen, and oxygen only; and where R.sup.80 is a group selected from (a) or (b);R.sup.21 is a non-interfering substituent;R.sup.1 is --NHNH.sub.2, --NH.sub.2 or --CONH.sub.2 ;R.sup.2' is selected from the group consisting of --OH, and --O(CH.sub.2).sub.t R.sup.5' whereR.sup.5' is H; --CN; --NH.sub.2 ; --CONH.sub.2 ; --CONR.sup.9 R.sup.10, where R.sup.9 and R.sup.10 are independently hydrogen, --CF.sub.3, phenyl, --(C.sub.1 -C.sub.4) alkyl, --(C.sub.1 -C.sub.4) alkylphenyl or -phenyl --(C.sub.1 -C.sub.4) alkyl; --NHSO.sub.2 R.sup.15 ; --CONHSO.sub.2 R.sup.15, where R.sup.15 is --(C.sub.1 -C.sub.6)alkyl or --CF.sub.3 ; phenyl or phenyl substituted with --CO.sub.2 H or --CO.sub.2 (C.sub.1 -C.sub.4)alkyl; and --(La)-(acidic group), wherein --(L.sub.a)-- is an acid linker having an acid linker length of 1 to 7 and t is 1-5;R.sup.3' is selected from non-interfering substituent, carbocyclic radicals, carbocyclic radicals substituted with non-interfering substituents, heterocyclic radicals, and heterocyclic radicals substituted with non-interfering substituents; or a pharmaceutically acceptable racemate, solvate, tautomer, optical isomer, prodrug derivative or salt thereof;provided that when R.sup.3' is H, R.sup.20 is benzyl and m is 1 or 2; R.sup.2' cannot be --O(CH.sub.2).sub.m H.