Patent ID: 6800649
Filing Date: 2004-10-05
Classification: A61K,C07D

Abstract:
A method for specifically inhibiting c-jun activation in mammalian or avian cells comprising contacting the cells with an effective inhibitory amount of a compound of formula I: whereinX is HN, R11N, S, O, CH2, or R11CH; R11, is hydrogen (C1-C4)alkyl, or (C1-C4)alkanoyl; R1-R8 are each independently hydrogen, hydroxy, mercapto, amino, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkylthio, or halo; wherein two adjacent groups of R1-R5 together with the phenyl ring to which they are attached may optionally form a fused ring; and further wherein the ring formed by the two adjacent groups of R1-R5 may optionally be substituted by 1, 2, 3, or 4 hydroxy, mercapto, amino, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkylthio, or halo; and R9 and R10 are each independently hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy, halo, or (C1-C4)alkanoyl; or R9 and R10 together are methylenedioxy, or a pharmaceutically acceptable salt thereof.