Patent ID: 6057453
Filing Date: 2000-05-02
Classification: A61P,C07C,C07D,C07F

Abstract:
A method for making a radiosensitizing diamine, the method comprising:(a) converting a compound having formula (5): ##STR45## to a compound having formula (6): ##STR46## using dimethyl sulfoxide activated by oxalyl chloride, and (b) treating the compound having formula (6) with a diamine reagent in the presence of an organic acid and a reducing agent, whereinthe radiosensitizing diamine has formula (1): ##STR47## R.sup.1, R.sup.2, R.sup.3, and R.sup.4 each have formula (2): ##STR48## A comprises a carbon chain having from 2 to about 10 carbons in the chain; A' comprises a carbon chain having from 1 to about 8 carbons in the chain;R.sup.5 is hydrogen, lower alkyl, or halo; andR.sup.6 is hydrogen, lower alkyl, halo, or nitro.