Patent ID: 7166586
Filing Date: 2007-01-23
Classification: A61P,C07D

Abstract:
1. A compound of formula II pharmaceutically acceptable salts, stereoisomers, or prodrugs thereof, wherein Y is a bond, alkyl, alkenyl or alkynyl; X is where m is an integer between 1 and 3; Q is R R R any of which may be optionally substituted with one or more groups Z 1b , Z 2b or Z 3b ; R R where n is an integer between 1 and 4 and wherein 1 to 4 of the methylene groups may be optionally mono- or di-substituted with alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, and heteroaryl, and which may be optionally substituted with 1 to 4 halogens except on a carbon that is directly bonded to a nitrogen; R Z Z Z Z provided that said compound is other than (a) a compound of structure X wherein R R R wherein the substructure is a group selected from where Z is O or S; (b) a compound of the structure XI wherein R R R R R R B is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or benzyl D is hydrogen, acetoxy, hydroxy or alkoxy; E is hydrogen or alkyl; or B and E together are an alkylene bridge; R G is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or benzyl; K is hydrogen, acetoxy, hydroxy or alkoxy; L is hydrogen or alkyl; or R M is selected from 1-aminopentyl-1 carbonyl, valyl, 2-tert-butylgylcyl, prolyl, hydroxyprolyl, isoleucyl, leucyl, 3-cyclohexylalanyl, phenylalanyl, tetrahydroisoquinolyl-2-carbonyl, 3-thiazolylalanyl, 3-thienylalanyl, histidyl, 2-aminoindyl-2-carbonyl, tyrosyl, 3-pryridylalanyl, 3-tert-butyalanyl, 2-cyclohexylglycyl or 3-napthylalanyl residues; Q* is hydroxy, alkoxy, phenoxy, benyloxy, amino or substituted amino; u and x are each independently 0 or 1; or (d) a compound of structure XIV wherein R R R R R R R q and r are each independently 1 or 2.