Patent ID: 6649169
Filing Date: 2003-11-18
Classification: A61P,C07K,C12N

Abstract:
A reassortant cold-adapted equine influenza A virus that grows at a temperature lower than about 34Â° C. and replicates in embryonated chicken eggs at a temperature ranging from about 26Â° C. to about 30Â° C., said reassortant virus comprising (a) at least one genome segment of a donor equine influenza virus generated by cold-adaptation, said equine influenza virus having an idenitifying phenotype selected from the group consisting of cold-adaptation, temperature sensitivity, dominant interference, and attenuation, wherein said equine influenza virus genome segment confers at least one of said identifying phenotypes to said reassortant virus, and (b) at least one genome segment of a recipient influenza A virus having an identifying phenotype selected from the group consisting of hemagglutinin activity and neuraminidase activity.