Patent ID: 6794507
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
A compound of formula (I): whereinX is Cl, Br or R1â€”N&boxH;CH(â€”NH2)â€” wherein R1 is H, â€”OH, â€”C(&boxH;O)OR2, aralkyl, an alkyloxy or a heteroalkyl group i R2 is alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl or aralkyl; Ar is arylene, heteroarylene, heteroarylalkylene or aralkylene, X being bonded directly to the aromatic ring system; R3 is H, alkyl, heteroalkyl or aralkyl; the groups R4 independently of one another are alkyl groups that may be substituted by one or more â€”OH or â€”NH2 radicals, or are heteroalkyl groups, carbocyclic groups, heterocycloalkyl groups, aryl groups, heteroaryl groups or aralkyl groups, it being possible for those groups to be substituted by one or more unsubstituted groups selected from alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl and aralkyl, or are hydroxyl groups or glycosyloxy groups; n is an integer from 0 to 5; R5 is H, alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl or aralkyl; R6 and R7 independently of each other are H, alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, such as, for example, aryl-heterocycloalkyl, aryl, heteroaryl, aralkyl or heteroarylalkyl, it being possible for those groups to be substituted by one or more groups selected from alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, aralkyl, â€”OH and â€”NH2, or together form part of a heterocycloalkyl ring system, or of a heteroaryl ring system, it being possible for those systems to be substituted by one or more groups selected from alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, aralkyl, â€”OH and â€”NH2; and R8 is H, alkyl, heteroalkyl, a carbocyclic group, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl or aralkyl or, together with R5, forms part of a heterocycloalkyl ring system; or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof.