Patent ID: 8372659
Filing Date: 2013-02-12
Classification: G01N

Abstract:
1. A sensing device for target biopolymers comprising; (a) a supporting cylinder configured for binding thermo-responsive magnetic nano particles having a critical solution temperature across which the particles have the ability to aggregate or disperse with cooling or heating to a ligand for the target biopolymers, and to label the target biopolymers in solution with said thermo-responsive magnetic nano particles bound with said ligand using a biopolymer reaction; (b) a pump configured to add ligand free thermo-responsive magnetic nano particles before the measurement of the magnetic signal which is performed after the biopolymer reaction; and (c) a cryostat configured to aggregate the thermo-responsive magnetic nano particles and enlarge the aggregate of said thermo-responsive magnetic nano particles by keeping at a temperature at which the thermo-responsive magnetic nano particles aggregate; (d) a sliding mechanism configured to transfer the biopolymer labeled with said aggregated and enlarged aggregate of the thermo-responsive magnetic nano particles; (e) a device configured to apply an AC magnetic field to said biopolymer; (f) a SQUID magnetic sensor positioned near the sample of the biopolymer and positioned above the cryostat, and (g) a device configured to measure a larger magnetic signal from the biopolymer compared with a magnetic signal obtained when said ligand free thermo-responsive magnetic nano particles are not added.