Patent ID: 8790656
Filing Date: 2014-07-29
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A vector comprising a replicon of Porcine Reproductive and Respiratory Virus (PRRSV) capable of in vivo replication, the replicon comprises (i) the 5′ noncoding region; (ii) the ORF1a and ORF1b; (iii) a replicon-ORF7 comprising a fragment of the ORF7 encoding nucleotides of a PRRSV, wherein the fragment comprises the region of the ORF7 that comprises ORF7 nucleotides 14642 to 14686 as identified in the nucleic acid sequence of the Lelystad virus isolate of PRRSV or an ORF7 encoding sequence from another PRRSV genome that aligns with nucleotides 14642 to 14686 of Lelystad virus and does not encode the complete ORF7 of said PRRS and (iv) the 3′ non-coding region, but no sequence corresponding to one or more of ORF2, ORF3, ORF4, ORF5 and ORF6 sequence of PRRSV.