Patent ID: 7244559
Filing Date: 2007-07-17
Classification: B01L,B82Y,C12P,C12Q,G01N

Abstract:
1. A substrate for analyzing a nucleic acid, the substrate comprising: a cavitated fiber optic wafer fonried from a fused bundle of a plurality of individual optical fibers, each individual optical fiber having a diameter between 3 and 100 μm, the wafer comprising a top surface and a bottom surface, the top surface comprising at least 10,000 wells, wherein said wells are etched into the top surface of the cavitated fiber optic wafer and wherein the thickness of the wafer between the top surface and the bottom surface is between 0.5 mm and 5.0 mm in thickness; wherein the depth of each well ranges from between one half the diameter of an individual optical fiber and three times the diameter of an individual optical fiber; and wherein a plurality of wells on the top surface of the cavitated wafer have a nucleic acid disposed therein; and a plurality of beads disposed within wells on the top surface of the cavitated wafer, said beads having a pyrophosphate sequencing reagent attached thereto.