Patent ID: 6017934
Filing Date: 2000-01-25
Classification: C07D

Abstract:
A compound having the following structure: ##STR31## wherein W ishydrogen,R.sup.1 --,R.sup.1 OC(O)--,R.sup.1 C(O)--,R.sup.1 SO.sub.2 --,(R.sup.1).sub.m (CH.sub.2).sub.n NH.sub.q C(O)--,where n is 0-4, m is 1 or 2, wherein R.sup.1 is same or different, and q is 0 or 1, with the proviso that where n is 1-4, q is 1 and m is 1, and where n is 0, m is 1 or 2, and q is 0 or 1, and where n is 0, m is 2 and q is 0;R.sup.1 isR.sup.17 (CH.sub.2).sub.t --, where t is 0-4;(R.sup.17)(OR.sup.17)CH(CH.sub.2).sub.p --, where p is 1-4,(R.sup.17).sub.2 CH(CH.sub.2).sub.r --, where r is 0-4 and each R.sup.17 can be the same or different, and wherein (R.sup.17).sub.2 can also form a ring with CH represented by C.sub.3-7 cycloalkyl, C.sub.7-12 bicylic alkyl, C.sub.10-16 tricylic alkyl, or a 5- to 7- membered mono- or bicyclic heterocyclic ring which can be saturated or unsaturated, and which contains from one to three heteroatoms selected from the group consisting of N, O and S,R.sup.17 O(CH.sub.2).sub.p --, wherein p is 1-4;R.sup.2, R.sup.14 and R.sup.17 are independently selected from-phenyl, unsubstituted or substituted with one or more ofC.sub.1-4 alkyl,C.sub.1-4 alkoxy,halogen,hydroxy,COOH, orCONH.sub.2,naphthyl,biphenyl,a 5- to 7-membered mono- or a 9- to 10-membered bicyclic heterocyclic ring which can be saturated or unsaturated, and which contains from one to four heteroatoms selected from the group consisting of N, O and S,--C.sub.1-7 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,amino,aryl,C.sub.3-7 cycloalkyl,heteroaryl, orheterocycloalkyl,--CF.sub.3C.sub.3-7 cycloalkyl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl;X isCF.sub.2,CR.sup.15, R.sup.16wherein R.sup.15 and R.sup.16 are independently hydrogen,C.sub.3-7 cycloalkyl,C.sub.1-4 alkyl unsubstituted or substituted with one or more of hydroxy,COOH,amino,aryl,heteroaryl, orheterocycloalkyl,aryl,heteroaryl,heterocycloalkyl, orR.sup.15 and R.sup.16 are joined to form a four to seven membered cycloalkyl ring unsubstituted or substituted with hydroxy, amino or aryl, orS(O).sub.r, where r is 0-2;R.sup.3 ishydrogen,C.sub.1-4 alkyl,C.sub.3-7 cycloalkyl, ortrifluoromethyl;A is chosen from one of the following radicals: ##STR32## with the proviso that when A is radical IV, R.sup.2 --X is not C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, or trifluoromethyl;R.sup.4 ishydrogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,halogen,--OCH.sub.2 CF.sub.3,--COOH,--OH,--COOR.sup.6, where R.sup.6 is C.sub.1-4 alkyl,--CONR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are independently hydrogen or C.sub.1-4 alkyl,--(CH.sub.2).sub.1-4 OH,--CH.sub.2 NHC(O)CH.sub.3,--CH.sub.2 NHC(O)CF.sub.3,--CH.sub.2 NHSO.sub.2 CH.sub.3,--SO.sub.2 NH.sub.2,--(CH.sub.2).sub.1-4 SO.sub.2 NR.sup.7 R.sup.8,--(CH.sub.2).sub.1-4 SO.sub.2 R.sup.6,a 5- to 7-membered mono- or a 9- to 10-membered bicyclic heterocyclic ring which can be saturated or unsaturated, and which contains from one to four heteroatoms selected from the group consisting of N, O and S,--ZCH.sub.2 CO.sub.2 H,--ZCH.sub.2 CO.sub.2 CH.sub.3,--ZCH.sub.2 R.sup.14,--ZCH.sub.2 CO.sub.2 (CH.sub.2).sub.1-3 CH.sub.3,--Z(CHR.sup.9).sub.1-3 C(O)NR.sup.10 R.sup.11,whereinR.sup.9 is H or C.sub.1-4 alkyl,R.sup.10 and R.sup.11 are independentlyhydrogen,C.sub.3-7 cycloalkyl,aryl,heteroaryl,heterocycloalkyl,C.sub.1-4 alkyl unsubstituted or substituted with one or more of hydroxy,COOH,amino,aryl,heteroaryl, orheterocycloalkyl, orR.sup.10 and R.sup.11 are joined to form a four to seven membered cycloalkyl ring unsubstituted or substituted with hydroxy, amino or aryl,wherein Z is O, S or CH.sub.2 ;R.sup.5 ishydrogen,halogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,CN, orCO.sub.2 NH.sub.2 ; andR.sup.12 and R.sup.13 are independentlyhydrogen,C.sub.1-4 linear or branched alkyl or alkoxy,C.sub.3-7 cycloalkyl,halogen, ortrifluoromethyl;and pharmaceutically acceptable salts thereof.