Patent ID: 6177565
Filing Date: 2001-01-23
Classification: C07D

Abstract:
A process for producing compound E by reacting compounds C and D: ##STR26##comprising the steps of:a) dissolving compounds C and D together in DMF;b) adding to said solution of C and D:i) a water scavenger;ii) a metal hydroxide selected from LiOH, NaOH or KOH; andiii) a phase transfer catalystc) allowing the mixture produced in step b) to react at room temperature for 2 to 48 hours;d) adding an organic solvent and water to said mixture to create an aqueous phase and an organic phase; ande) purifying compound E from said organic phase;wherein:R.sub.2 is selected from hydrogen, C1-C6 straight or branched alkyl, C2-C6 straight or branched alkenyl or alkynyl or Ar, wherein said alkyl, alkenyl or alkynyl is optionally substituted with Ar;n is 0 or 1;""Hal"" is any halogen; andeach R' is an independently selected carboxyl protecting group.