Patent ID: 9040543
Filing Date: 2015-05-26
Classification: A61K,A61P,C07D

Abstract:
1. A method of inhibiting an activity of a JAK kinase, comprising contacting the JAK kinase with an amount of a compound effective to inhibit an activity of the JAK kinase, wherein the compound is a compound of formula I or pharmaceutically acceptable salt thereof, wherein: ring A is heteroaryl; p is 0, 1, 2 or 3 when ring A is monocyclic or p is 0, 1, 2, 3, 4, or 5 when ring A is bi- or tricyclic; q is 0,1,2 or 3; X is selected from the group consisting of hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halo, nitro, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkynyl, substituted cycloalkynyl; Y is selected from the group consisting of hydrogen, alk W is selected from the group consisting of alk alk R each R R Z each R R R R R provided that when X is hydrogen, ring A is not benzimidazolyl or indazolyl.