Patent ID: 8648094
Filing Date: 2014-02-11
Classification: A61P,C07D,C07K,G01N

Abstract:
1. A method of enhancing apoptosis in a cell comprising contacting the cell with a compound of Formula IA: including any enantiomer, diastereoisomer or tautomer thereof, wherein: n is 0 or 1; m is 0, 1 or 2; Y is NH, O or S; X and X Q and Q A and A BG is or BG is —Y Y L, L wherein the alkyl, the alkenyl, the alkynyl, the cycloalkyenyl and the cycloalkyl are optionally substituted with one or more R Z is selected from: wherein the alkyl and the cycloalkyl are optionally substituted with one or more R R R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the aryl, heteroaryl, heterocyclyl, and heterobicyclyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R or R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R wherein the alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl are optionally substituted with one or more R R or R or a pharmaceutically acceptable salt thereof; whereby apoptosis in the cell is enhanced.