Patent ID: 7651846
Filing Date: 2010-01-26
Classification: A61K,A61P,Y10T

Abstract:
1. A method of testing a sample from a human subject having or suspected of having a condition having elevated arginase activity, the method comprising: a) detecting a level of arginine and a level of ornithine in a biological sample from the subject, where the biological sample comprises blood, plasma, or serum; and b) determining a ratio of the arginine level to the ornithine level, wherein an arginine to ornithine ratio of more than 25% reduced versus indicates that the subject has a condition having elevated arginase activity, and wherein the condition is at least one of acute exacerbation of asthma, sickle cell disease, pulmonary hypertension, pulmonary arterial hypertension (PAH), and thalassemia.