Patent ID: 6462173
Filing Date: 2002-10-08
Classification: A61K,A61P,C07K

Abstract:
An inhibitor of a phosphoserine- or phosphothreonine-proline specific peptidyl-prolyl isomerase comprising a peptide or peptide mimetic wherein the peptide or peptide mimetic comprises two to ten amino acids and wherein the inhibitor has a core moiety having a formula: wherein:x is a negatively charged tetra or pentavalent moiety; X4 is Arg or an aromatic amino acid; and Y is Pro or a Pro analog represented by one of the following structural formulas: wherein: ring A is a 4 to 7-membered substituted or unsubstituted heterocyclic group; and R is selected from the group consisting of imidazolyl, pyrrolyl, tropolonyl, phenyl and camphoryl.