Patent ID: 7910561
Filing Date: 2011-03-22
Classification: A61P,C07D

Abstract:
1. A compound selected from: 3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 2-(4-{[4-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 6-Methyl-3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]-methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 6-(2-Hydroxyethyl)-3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-Phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,7-naphthyridin-8(7H)-one; 2-(4-{[4-(1,3-Benzoxazol-2-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[445-pyridin-2-yl-2H-tetrazol-2-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(4-pyridin-2-yl-1H-1,2,3-triazol-1-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(1-pyridin-2-yl-1H-pyrrol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1,3-thiazol-2-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(3-pyrimidin-4-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 2-(4-{[4-(1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 2-(4-{[4-fluoro-4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(3-pyridin-2-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 2-(4-{[4-hydroxy-4-(1-pyridin-2-yl-1H-pyrazol-4-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyridin-2-ylpiperidine-4-carboxamide; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-(pyridin-2-ylmethyl)piperidine-4-carboxamide; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyrimidin-2-ylpiperidine-4-carboxamide; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyrazin-2-ylpiperidine-4-carboxamide; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyrimidin-4-ylpiperidine-4-carboxamide; 3-Phenyl-2-(4-{[4-(3-pyridin-2-yl-1H-pyrrol-1-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-Phenyl-2-(4-{[4-(4-pyridin-2-yl-1H-pyrazol-1-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-Phenyl-2-(4-{[4-(1-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(pyrimidin-2-ylamino)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-Phenyl-2-{4-[(4-pyridin-4-ylpiperidin-1-yl)methyl]phenyl}-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-{4-[(4-phenylpiperidin-1-yl)methyl]phenyl}-1,6-naphthyridin-5(6H)-one; 2-(4-{[4-(3-benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(4-pyridin-2-yl-M-imidazol-1-yl)piperidin-1-yl]methyl}phenyl-1,6-naphthyridin-5(6H)-one; 5-methoxy-3-phenyl-2-(4-{[3-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridine; 3-phenyl-2-(4-{[3-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 5-methoxy-3-phenyl-2-(4-{[(3R,4R)-3-methyl-4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridine; 3-phenyl-2-(4-{[(3R,4R)-3-methyl-4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; (3R)-N-(4-fluorophenyl)-1-[4-(5-methoxy)-3-phenyl-1,6-naphthyridin-2-yl)benzyl]pyrrolidine-3-carboxamide; (3R)-N-(4-fluorophenyl)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyrrolidine-3-carboxamide; (3R)-N-(3-fluorophenyl)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyrrolidine-3-carboxamide; 3-phenyl-2-(4-{[3-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)-4-(trifluoromethyl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; (3R)-N-(2-fluorophenyl)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyrrolidine-3-carboxamide; (3R)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyridin-4-ylpyrrolidine-3-carboxamide; (3R)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyridin-3-ylpyrrolidine-3-carboxamide; (3R)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-N-pyridin-2-ylpyrroldine-3-carboxamide; 2,2,2-trifluoro-N-{(3R)-1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyridin-3-yl}acetamide; 3-Phenyl-2-(4-{[(3S)-3-(2-thienylcarbonyl)pyrrolidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; {(3S)-1-[4-(5-Methoxy-3-phenyl-1,6-naphthyridin-2-yl)benzyl]pyrrolidin-3-yl}(2-thienyl)methanone; N-{1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyrrolidine-3-yl}-N′-phenylurea; N-{1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]pyrrolidin-3-yl}-N′-pyridin-4-ylurea; 2-[4-({4-[5-(6-Hydroxypyridin-3-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl]methyl)phenyl}-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(2-pyridin-2-yl-1,3-thiazol-4-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(2-pyridin-3-yl-1H-imidazol-5-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(1-pyridin-2-yl-1H-imidazol-4-yl)piperidine-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl]-4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)piperazine; 1-[4-(5-methoxy-3-phenyl-1,6-naphthyridin-2-yl)benzyl]-4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)piperazine; 1-{1-[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)phenyl]ethyl}-445-pyridin-2-yl-4-h-1,2,4-triazol-3-yl)piperidine; 2-[4-({4-[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl]methyl)phenyl}-3-phenyl-1,6-naphthyridin-5(6H)-one; 2-[4-({3-[4-(dimethylamino)phenyl]pyrrolidin-1-yl}methyl)phenyl]-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; 2-[4-({4-[5-(6-chloropyridin-3-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl]methyl)phenyl}-3-phenyl-1,6-naphthyridin-5(6H)-one; 3-phenyl-2-(4-{[4-(5-pyrazin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; and 3-phenyl-2-(4-{[4-(1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one; or a pharmaceutically acceptable salt or a stereoisomer thereof.