Patent ID: 7049136
Filing Date: 2006-05-23
Classification: A61K,C07K,C12N

Abstract:
1. A cell expressing a proteinaceous membrane-bound chimeric receptor, the first of said receptor comprising (a) an extracellular portion which is capable of specifically recognizing and binding a target cell or a target infective agent, (b) a transmembrane portion derived from a T cell receptor, a B cell receptor, or an Fc receptor protein which, in the absence of an intracellular signalling domain, is capable of signalling said cell to destroy a receptor-bound target cell or a receptor-bound target infective agent, and (c) an intracellular domain that does not signal said cell to destroy a receptor-bound target cell or receptor-bound target infective agent; and the second of said receptors comprising (a) an extracellular portion which is capable of specifically recoginizing and binding said target cell or said target infective agent, and (b) an intracellular portion which is derived for CD28.