Patent ID: 6511995
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A pyridine derivative represented by the general formula (1): wherein R1 represents a halogen atom or a halogen-substituted lower alkyl group; R2 and R3 are the same or different and represent a hydrogen atom or a halogen atom; V represents a group: â€”C(&boxH;O)â€”NHâ€”, a group: â€”NHâ€”C(&boxH;O)â€”, a group: â€”NHâ€”C(&boxH;O)â€”NHâ€” or a group: â€”CH&boxH;CHâ€”; A represents a group A1: (wherein R4 represents a hydrogen atom or a 2-lower alkyl-1,3-dioxolane group; R5 represents a hydrogen atom or a 2-lower alkyl-1,3-dioxolane group; and R6 represents a hydrogen atom, provided that one of R4 and R5 is a 2-lower alkyl-1,3-dioxolane group and the other of R4 and R5 is a hydrogen atom), a group A2: ((wherein R7 represents a hydrogen atom or a lower alkyl group; R8 may be the same or different and represents a hydrogen atom, a hydroxyl group, an oxo group, a lower alkanoyloxy group, an aroyloxy group, a lower alkoxy group, a group: (wherein k represents an integer of 1 to 3) or a group: &boxH;Nâ€”OR10 (wherein R10 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group); p represents an integer of 1 to 2; {overscore (----)}represents a single bond or a double bond; Y represents a group: â€”(CH2)mâ€”, a group: &boxH;CH(CH2)m-1â€” or a group: â€”(CH2)m-1CH&boxH;; and m represents an integer of 1 to 3)) or a group A3: ((wherein R9 may be the same or different and represents a hydrogen atom, a hydroxyl group, an oxo group, a lower alkanoyloxy group, an aroyloxy group, a lower alkoxy group, a group: (wherein k represents an integer of 1 to 3) or a group; 1 represents an a hydrogen atom, a lower alkyl group or a lower alkanoyl group); q represents an integer of 1 to 2; {overscore (----)}represents a single bond or a double bond; Z represents a group: â€”(CH2)nâ€”, a group: &boxH;CH(CH2)n-1â€” or a group: â€”(CH2)n-1CH&boxH;; and n represents an integer of 1 to 3)) or a salt thereof.