Patent ID: 8673306
Filing Date: 2014-03-18
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an isolated antibody or a functional fragment thereof comprising: (a) CDR sequences of a variable heavy chain comprising: CDR1 with a sequence comprising amino acids 26 to 35 of SEQ ID NO: 11, CDR2 with a sequence comprising amino acids 47 to 66 of SEQ ID NO: 11, and CDR3 with a sequence comprising amino acids 99 to 105 of SEQ ID NO: 11, and (b) CDR sequences of a variable light chain comprising: CDR1 with a sequence comprising amino acids 23 to 36 of SEQ ID NO: 30, CDR2 with a sequence comprising amino acids 48 to 58 of SEQ ID NO: 30, and CDR3 with a sequence comprising amino acids 91 to 100 of SEQ ID NO: 30, wherein the antibody or functional fragment thereof specifically binds to human DKK1 and/or human DKK4.