Patent ID: 8268617
Filing Date: 2012-09-18
Classification: A61K,A61P,C07K

Abstract:
1. An isolated polynucleotide encoding a light chain variable region and a heavy chain variable region of an antibody or antibody fragment that binds IGF-IR, wherein said heavy chain variable region comprises three complementarity-determining regions (CDRHs) comprising the amino acid sequences of SEQ ID NOS:1 (CDRH1), 2 or 54 (CDRH2) and 3 (CDRH3), respectively; and wherein said light chain variable region comprises three complementarity-determining regions (CDRLs) comprising the amino acid sequences of SEQ ID NOS:4 (CDRL1), 5 (CDRL2) and 6 (CDRL3), respectively.