Patent ID: 7807369
Filing Date: 2010-10-05
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for treating anogenital intraepithelial neoplasia in a subject, comprising the steps of: (a) measuring or detecting the presence of a CD4+ type 1 T helper (Th1) cell response against an human papilloma virus (HPV) early antigen of HPV protein E2, E6 or E7 in said subject to ascertain whether the subject has a detectable CD4+ Th1cell response against said antigen; and (b) in a subject in whom said CD4+ Th1-cell response is detectable, (c) in a subject in whom said CD4+ Th1cell response is undetectable, immunizing the subject with said early HPV antigen to elicit said antigen-specific Th1cell response and, concurrently or thereafter, locally administering to or near said lesion an effective amount of the TLR-7 activating compound, thereby inducing local inflammation, wherein the local inflammation produced by the local administration of the TLR-7 activating compound and the Th1cell response present in the subject, with or without said immunization of step (b)(ii) or (c), results in treatment of said neoplasia.