Patent ID: 6080738
Filing Date: 2000-06-27
Classification: A61K,C07K

Abstract:
A heterocyclic amide compound of the formula (I) ##STR353## wherein R is a hydrogen atom, alkyl, --CHO, --CONH.sub.2, --COR.sup.1, --COOR.sup.1, --CONHOR.sup.1, --CONHR.sup.1, --CONR.sup.1 R.sup.1 ', --CONHSO.sub.2 R.sup.1, --COSR.sup.1, --COCOR.sup.2, --COCOOR.sup.2, --CONHCOOR.sup.2, --COCONR.sup.3 R.sup.4, --CSXR.sup.1, --SO.sub.2 WR.sup.1, --SO.sub.2 NR.sup.1 R.sup.1 ' or --SO.sub.2 Ewherein R.sup.1 and R.sup.1 ' may be the same or different and each is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle or heterocyclic alkyl, R.sup.2, R.sup.3 and R.sup.4 may be the same or different and each is independently a hydrogen atom, alkyl or arylalkyl, or --NR.sup.3 R.sup.4 may in combination form a heterocycle, X is a single bond, --NH--, --O-- or --S--, W is a single bond, --NH--, --NHCO--, --NHCOO-- or --NHCONH--, and E is a hydroxyl group or amino;R.sup.5 and R.sup.7 may be the same or different and each is independently hydrogen atom or alkyl, or one of R.sup.5 and R.sup.7 is aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl or heteroarylalkenyl and the rest is hydrogen atom;M is and R.sup.6 is void;Y is cycloalkyl, aryl or heteroaryl;Z is a group of the formula (i) ##STR354## FORMULA (ii) ##STR355## formula (iii) ##STR356## wherein R.sup.8 and R.sup.9 may be the same or different and each is independently hydrogen atom, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, halogen, trifluoromethyl, cyano, nitro, --NR.sup.10 R.sup.10 ', --NHSO.sub.2 R.sup.10, --OR.sup.10, --COOR.sup.10, --CONHSO.sub.2 R.sup.10 or --CONR.sup.10 R.sup.10 ' wherein R.sup.10 and R.sup.10 ' may be the same or different and each is independently hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl or trifluoromethyl, or --NR.sup.10 R.sup.10 ' may in combination form heterocycle, A is --O--, --S-- or --NR.sup.12 -- wherein R.sup.12 is a hydrogen atom, alkyl, cycloalkyl or cycloalkylalkyl, and a, b, c and d are each a carbon atom or one of them is a nitrogen atom and the rest is a carbon atom; andn is 0 or 1,wherein, of the above-mentioned groups, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heterocycle and heterocyclic alkyl each optionally has a substituent, or a pharmacologically acceptable salt thereof.