Patent ID: 6063930
Filing Date: 2000-05-16
Classification: C07D

Abstract:
A compound represented by formula I: ##STR10## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1a, R.sup.1b and R.sup.2 are independently selected from the group consisting of: hydrogen, aryl, substituted aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, R.sup.8 O--, R.sup.9 S(O).sub.m -- wherein m is 0, 1 or 2, R.sup.8 C(O)NR.sup.8 --, CN, NO.sub.2, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2, R.sup.9 OC(O)NR.sup.8 -- and C.sub.1 -C.sub.6 alkyl, unsubstituted or substituted by 1-3 groups selected from the group consisting of: halo, aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, R.sup.8 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NR.sup.8 --, CN, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2 and R.sup.9 OC(O)NR.sup.8 --;R.sup.3 and R.sup.4 are independently selected from the group consisting of: H, F, Cl, Br, --NR.sup.8.sub.2, CF.sub.3, NO.sub.2, R.sup.8 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NH--, H.sub.2 NC(NH)--, R.sup.8 C(O)--, R.sup.8 C(O)--, N.sub.3, CN, R.sup.9 OC(O)NR.sup.8 --, C.sub.1 -C.sub.20 alkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;A.sup.3 is selected from: --C.tbd.C--, --R.sup.8 C.dbd.CR.sup.8 --, aryl heteroaryl, --C(O)-- or a bond; provided that when A.sup.3 is heteroaryl, attachment of A.sup.3 to the remainder of the molecule is through ring carbons of A.sup.3 ;X represents aryl or heteroaryl; provided that when X is heteroaryl, attachment of X the remainder of the molecule is through ring carbons of X;R.sup.6 is independently selected from the group consisting of: hydrogen, aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -.sub.6 perfluoroalkyl, F, Cl, Br, R.sup.8 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NR.sup.8, CN, NO.sub.2, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2, R.sup.9 OC(O)NR.sup.8 -- and C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by 1-3 groups selected from: aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, perfluoroalkyl, F, Cl, Br, R.sup.8 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NR.sup.8 --, CN, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2 and R.sup.9 OC(O)NR.sup.8 --;R.sup.7 is independently selected from the group consisting of: hydrogen, aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -.sub.6 perfluoroalkyl, F, Cl, Br, R.sup.9 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NR.sup.8, CN, NO.sub.2, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2, R.sup.9 OC(O)NR.sup.8 -- and C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by 1-3 groups selected from: aryl, heterocyclyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, perfluoroalkyl, F, Cl, Br, R.sup.8 O--, R.sup.9 S(O).sub.m --, R.sup.8 C(O)NR.sup.8 --, CN, (R.sup.8).sub.2 NC(NR.sup.8)--, R.sup.8 C(O)--, R.sup.8 OC(O)--, N.sub.3, --N(R.sup.8).sub.2 and R.sup.9 OC(O)NR.sup.8 --;each R.sup.8 is independently selected from hydrogen, C.sub.1 -C.sub.6 alkyl, aryl and aralkyl;each R.sup.9 is independently selected from C.sub.1 -C.sub.6 alkyl and aryl;A.sup.1 and A.sup.2 are independently selected from the group consisting of: a bond, --CH.dbd.CH--, --C.tbd.C--, --C(O)--, --C(O)NR.sup.8 --, --NR.sup.8 C(O)--, --O--, --N(R.sup.8)--, --S(O).sub.2 N(R.sup.8)--, --N(R.sup.8)S(O).sub.2 --, and S(O).sub.m ;V is selected from the group consisting of: hydrogen, heterocyclyl, aryl, C.sub.1 -C.sub.20 alkyl wherein from 0 to 4 carbon atoms are replaced with a heteroatom selected from O, S, and N, and C.sub.2 -C.sub.20 alkenyl,provided that V is not hydrogen if A.sup.1 is S(O).sub.m and V is not hydrogen if A.sup.1 is a bond, n is 0 and A.sup.2 is S(O).sub.m ;provided that when V is heterocycle, attachment of V to R.sup.8 and to A.sup.1 is through a ring carbon of V;W represents heterocyclyl;each n and p independently represents 0, 1, 2, 3 or 4;r is 0 to 5, provided that r is 0 when V is hydrogen, andt is 1.