Patent ID: 6153612
Filing Date: 2000-11-28
Classification: A61P,C07D

Abstract:
A compound of the Formula I ##STR12## wherein: Ar is selected from phenyl; phenyl substituted with alkyl, --NO.sub.2, halogen, --OR.sup.5, --CN, --CO.sub.2 R.sup.5, --SO.sub.3 R.sup.5, --CHO, --COR.sup.5, --CONHR.sup.5, --NHR.sup.5, or --NHCOR.sup.5 ;R.sup.1 is hydrogen, methyl, --NO.sub.2, --Cl, --NH.sub.2, --NHCO.sub.2 CH.sub.3, --OH, or --CO.sub.2 H;R.sup.2 and R.sup.3 and R.sup.a are the same or different and are independently selected from hydrogen, alkyl, --(CH.sub.2).sub.y -phenyl, --(CH.sub.2).sub.y -indolyl, --(CH.sub.2).sub.v -cycloalkyl, --(CH.sub.2).sub.t NR.sup.6 R.sup.6a, --(CH.sub.2).sub.v R.sup.7, --(CH.sub.2).sub.v CO.sub.2 R.sup.5, --(CH.sub.2).sub.v CONR.sup.6 R.sup.6a, or --(CH.sub.2).sub.v SR.sup.5 ;m is zero;Y is N;z is zero or 1;W is --CHR.sup.8 ;n is zero or 1;R.sup.4 is --OH, --NR.sup.6 R.sup.6a, or --NHOR.sup.9 ;R.sup.5 is hydrogen or alkyl;v is 1 to 5;X is O or S;p and q are independently 1 to 5, provided that p+q is not greater than 5;R.sup.6 and R.sup.6a are each the same or different and are hydrogen or alkyl;R.sup.7 is 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl, or 1,3-dihydro-1,3-dioxo-benzo[f]isoindol-2-yl;R.sup.8 is hydrogen or alkyl; andR.sup.9 is hydrogen, alkyl, or benzyl; ora pharmaceutically acceptable salt thereof.