Patent ID: 8765932
Filing Date: 2014-07-01
Classification: A61P,C12N

Abstract:
1. A method of inhibiting XBP-1 expression in a cell, the method comprising: (a) introducing into the cell a double stranded RNA (dsRNA), wherein said dsRNA comprises a sense strand and an antisense strand that together form a region of complementarity less than 30 base pairs in length, and wherein said sense strand and said antisense strand are each less than 30 nucleotides in length, and wherein said antisense strand is complementary to at least 15 contiguous nucleotides of CACCCUGAAUUCAUUGUCU (SEQ ID NO: 2149); and (b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of an XBP-1 gene, thereby inhibiting expression of the XBP-1 gene in the cell.