Patent ID: 6218148
Filing Date: 2001-04-17
Classification: A61K,A61P,C07K,Y02A,Y10S

Abstract:
An isolated DNA sequence encoding a polypeptide product having the hematopoietic biological activity of stimulating growth of early hematopoietic progenitor cells, said DNA sequence selected from the group consisting of:(a) DNA sequences set forth FIG. 15B, FIG. 15C, FIG. 42A-D, FIG. 44A-C, or their complementary strands;(b) DNA sequences which hybridize to the DNA sequences defined in (a) or fragments thereof, or DNA sequences whose coding regions hybridize to the DNA sequences defined in (a) or fragments thereof, the polypeptide fragment encoded by said DNA possessing hematopoietic biological activity, wherein hybridization conditions are defined as(i) bringing together said hybridizing DNA with said DNA of subpart (a) or fragments thereof in the presence of 1% SDS and 6.times.SSC at 62.degree. C. for an appropriate length of time; and removing unhybridized DNA in the presence 1% SDS and 6.times.SSC at 62.degree. C.; or(ii) more stringent conditions; and,(c) isolated DNA sequences differing from the isolated DNAs of (a) or (b) above in nucleotide sequence due to the degeneracy of the genetic code, and which encode a polypeptide product having the hematopoietic biological activity of stimulating growth of early hematopoietic progenitor cells.