Patent ID: 7109159
Filing Date: 2006-09-19
Classification: A61K,A61P

Abstract:
1. A method for treating tumors in mammals or for inhibiting tumor cell proliferation in mammals, comprising administering to a mammal in need thereof an effective amount of an active agent selected from the group consisting of (a) leptin; (b) a mutein of leptin having at least 90% identity with the sequence of a leptin and has the ability to inhibit the IGF-1 induced or insulin-induced proliferation of the human breast cancer cell line T-47D or MCF7, or having a sequence encoded by a nucleic acid that hybridizes to a nucleic acid which encodes leptin under stringent conditions that include washing conditions 12–20° C. below the calculated Tm of the hybrid under study, and has the ability to inhibit the IGF-1 induced or insulin-induced proliferation of the human breast cancer cell line T-47D or MCF7; (c) a fragment of one of (a) or (b) which has the ability to inhibit the IGF-I induced or insulin-induced proliferation of the human breast cancer cell line T-47D or MCF7; (d) a fusion protein comprising (a), (b) or (c); (e) a salt of any one of (a)–(d); and (f) a functional derivative of any of (a)–(d) selected from the group consisting of one or more polyethylene glycol side chains formed by means of functional groups which occur as side chains of any of (a)–(d), aliphatic esters of one or more carboxyl groups, amides of one or more carboxyl groups by reaction with ammonia or with primary or secondary famines, N-acyl derivatives of one or more free amino groups of the amino acid residues formed with acyl moieties, O-acyl derivatives of free hydroxyl groups formed with acyl moieties, and combinations thereof.