Patent ID: 8343503
Filing Date: 2013-01-01
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising a plurality of contiguous overlapping peptide fragments comprising a first peptide consisting of the sequence from amino acid 2 to amino acids 42-52 of SEQ ID NO: 9 wherein the reactivity of said first peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained; a second polypeptide consisting of the sequence from amino acids 42-52 to amino acids 96-131 of SEQ ID NO: 9 wherein the reactivity of said second peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained and a third peptide consisting of the sequence from amino acids 96-131 to amino acid 160 of SEQ ID NO: 9 wherein the reactivity of said third peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.