Patent ID: 7642266
Filing Date: 2010-01-05
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of the compounds of the formula: or a pharmaceutically acceptable salt of the compound of Formula (I), wherein: X is —O— or —S—; Ar is selected from the group consisting of fused aryl, heteroaryl, and fused heteroaryl, wherein each of the aryl, fused aryl, heteroaryl, and fused heteroaryl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, cycloalkyl, heterocyclylalkyl, —CF R wherein each of the alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, cycloalkyl, cycloalkylalkyl, alkenylalkyl, alkynylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl and the heterocyclic moieties shown immediately above for R 1 can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, cycloalkyl, heterocyclylalkyl, CF 3 , OCF 3 , CN, —OR 5 , —NR 5 R 10 , —(CR 4 R 5 ) p —R 9 , —N(R 5 )Boc, —(CR 4 R 5 ) p OR 5 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 10 , —SO 3 H, —SR 10 , —S(O 2 )R 7 , —S(O 2 )NR 5 R 10 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 10 ; R wherein each of the alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, cycloalkyl, cycloalkylalkyl, alkenylalkyl, alkynylalkyl, heterocyclyl, heterocyclylalkyl, heteroarylalkyl and the heterocyclic moieties shown immediately above for R 2 can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, cycloalkyl, heterocyclylalkyl, CF 3 , OCF 3 , CN, —OR 5 , —NR 5 R 10 , —(CR 4 R 5 ) p —R 9 , —N(R 5 )Boc, —(CR 4 R 5 ) p OR 5 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 10 , —SO 3 H, —SR 10 , —S(O 2 )R 7 , —S(O 2 )NR 5 R 10 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 10 ; R wherein each of the alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, cycloalkyl, cycloalkylalkyl, alkenylalkyl, alkynylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl and the heterocyclic moieties shown immediately above for R 3 can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halo, alkyl, aryl, cycloalkyl, heterocyclylalkyl, CF 3 , OCF 3 , CN, —OR 5 , —NR 5 R 10 , —(CR 4 R 5 ) p —R 9 , —N(R 5 )Boc, —(CR 4 R 5 ) p OR 5 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 10 , —SO 3 H, —SR 10 , —S(O 2 )R 7 , —S(O 2 )NR 5 R 10 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 10 ; R R R R R R R R R m is 0 to 4; n is 1to 4; and p is 1 to 4, wherein Boc refers to butoxycarbonyl; with the following proviso: when X is —S—, then Ar is not pyridyl.