Patent ID: 6680198
Filing Date: 2004-01-20
Classification: A61K,A61P,C12N

Abstract:
A primordial human neural stem cell clone comprising both EGF and bFGF receptors maintained as a stable and identifiable cell line in vitro and suitable for on-demand implantation in vivo into a living host subject, said primordial human neural stem cell clone comprising a pluripotent and self-renewing neural stem cell of human origin, whichi) carries native human genomic DNA, which has not been genetically modified by human intervention means; ii) remains uncommitted and undifferentiated while passaged in vitro using epigenetic means as a mitotic cell line; iii) is capable of migrating in vivo after implantation from the implantation site to another anatomic site for in vivo integration within the nervous system of the living host subject; iv) is capable of integrating in situ after implantation into the parenchymal tissues at a local anatomic site in the living host subject; v) is capable of differentiating in situ into any one of neuronal cell types selected from the group consisting of neurons, oligodendroglia and astroglia as a response to signals in vivo; and vi) expresses both EGF and bFGF receptors.