Patent ID: 6277873
Filing Date: 2001-08-21
Classification: C07D

Abstract:
A compound of the formula: ##STR33##wherein:Ar is phenyl, thienyl or pyridyl substituted by R.sup.1 and R.sup.2 ; where R.sup.1 and R.sup.2 are the same or different and represent hydrogen, halo, alkyl, alkenyl, alkynyl, aryl, alkoxy, aryloxy, alkylthio, amino, hydroxy, cyano, nitro, carboxy, aminocarbonyl, aminosulfonyl, alkylamino, dialkylamino, acylamino, dialkylaminosulfonyl, alkylaminosulfonyl or, taken together, R.sup.1 and R.sup.2 may be combined to form --O--(CH.sub.2).sub.n --O-- where n is an integer having a value of 1 or 2;R.sup.3 and R.sup.4 are the same or different and represent hydrogen, alkyl which may be optionally substituted by amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkenyl, alkynyl or acyl or taken together R.sup.3 and R.sup.4 may be combined to form --(CH.sub.2).sub.m --Q--(CH.sub.2).sub.m -- where Q is selected from among CH.sub.2, O, S(O).sub.n', and NR.sup.7 where n' is an integer having a value of 0, 1, or 2, R.sup.7 is lower alkyl and m and m' are integers having a value of 2, with the proviso that when Q is CH.sub.2, m' may also have a value of 1;R.sup.5 is H, halo, OR, OH, NO.sub.2, NH.sub.2 and NHCOR where R is alkyl, lower alkyl or aryl; andV is N, O or S, or when V is N, it may be combined with R.sup.3 and R.sup.4 to form a heterocycle selected from among pyrrole, imidazol-1,2,4,-triazole, 1,3,4-triazole and pyrazole, and when V is O or S, R.sup.3 and R.sup.4 combine to form a single substituent having the definition of R.sup.4 alone; p is 1-3; or a non-toxic pharmacologically acceptable salt thereof.