Patent ID: 9101613
Filing Date: 2015-08-11
Classification: A61K,C07D

Abstract:
1. A method for promoting neurite outgrowth, inhibiting neuronal loss, increasing sleep efficiency, enhancing learning and memory, or augmenting sleep maintenance, which comprises administering to an animal or human in need thereof a formulation comprising an effective amount of a compound having the formula wherein —B— represents —X—Y—Z— wherein X represents —(CH wherein Y represents oxygen, sulphur, >NH or is absent; wherein Z represents >C═O, >O or >COO or is absent; wherein at least one of X, Y and Z must be present; wherein Ar represents an indole nucleus ring system: wherein Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system: wherein each of R wherein each of R C 1-5 alkylamido, hydroxy, thiol, acyloxy, azido, C 1-5 alkoxy, carboxy, carbonylamido or styryl; wherein said arylalkyl, arylalkenyl, aralalkynyl, or styryl group optionally can be ring-substituted by one to four substituents independently selected from the group consisting of hydrogen, halo, halo-C C 1-5 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, aryl-C 1-5 alkyl, aryl-C 2-5 alkenyl, aryl-C 2-5 alkynyl, hydroxy-C 1-5 alkyl, nitro, amino, cyano, cyanamide, guanidino, amidino, acylamido, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido, S-alkyl or alkylthiol; and either of R 3 or R 4 further can include or represent a bond to B; and wherein Ar can be bonded to B at any position on the five-membered ring portion of the Ar ring, including the N-position, and Ar′ can be bonded to B at any carbon on the Ar′ ring not substituted by R