Patent ID: 6057350
Filing Date: 2000-05-02
Classification: C07C,C07D

Abstract:
A compound of the formula: ##STR61## wherein Q is ##STR62## E, G, L and M are each independently hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.15, (CH.sub.2).sub.0-4 N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15 or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2 ;J is hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.15, (CH.sub.2).sub.1-4 N(R.sup.16).sub.2, (CH.sub.2).sub.1-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sub.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15 or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2 ;R.sup.1 is unsubstituted, mono- or poly-substituted phenyl wherein the substitutents on the phenyl are independently selected from halogen, CF.sub.3, cyano, nitro, N(R.sup.16).sub.2, NR.sup.16 COR.sup.18, NR.sup.16 CON(R.sup.18).sub.2, NR.sup.16 SO.sub.2 R.sup.18, NR.sup.16 SO.sub.2 N(R.sup.18).sub.2, OR.sup.15, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15 and C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl wherein the substituents on the pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl are independently selected from CF.sub.3, cyano, nitro, N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15, phenyl, OR.sup.15, halogen, C.sub.1-4 alkyl and .sub.3-8 cycloalkyl;R is hydrogen, cyano, OR.sup.15, CO.sub.2 R.sup.15, CON(R.sup.16).sub.2, SO.sub.2 R.sup.15, SO.sub.2 N(R.sup.16).sub.2, tetrazole, isooxadiazole, unsubstituted, mono- or poly-substituted phenyl wherein the substitutents on the phenyl are independently selected from halogen, cyano, OR.sup.15, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, N(R.sup.16).sub.2, NR.sup.16 COR.sup.15, NR.sup.16 CON(R.sup.18).sub.2, NR.sup.16 SO.sub.2 R.sup.15, NR.sup.16 SO.sub.2 N(R.sup.18).sub.2, (CH.sub.2).sub.0 SO.sub.2 N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15 and C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, thienyl, furanyl or naphthyl wherein the substituents on the pyridyl, thienyl, furanyl or naphthyl are independently selected from CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15, phenyl, OR.sup.15, halogen, C.sub.1-4 alkyl and C.sub.3-8 cycloalkyl;R.sup.2 and R.sup.7 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.4-8 cycloalkyl, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.16, (CH.sub.2).sub.0-4 CON(R.sup.16).sub.2, (CH.sub.2).sub.0-4 COR.sup.15, (CH.sub.2).sub.2-4 OR.sup.15, (CH.sub.2).sub.1-4 CF.sub.3, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.15, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.16).sub.2 or (CH.sub.2).sub.1-4 CN;R.sup.3, R.sup.6, R.sup.8, R.sup.9 and R.sup.10 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.15 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.15 is hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.16 and R.sup.18 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.1-4 CF.sub.3 ;each X is independently halogen, cyano, nitro, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.24 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.24 is hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.0-4 CF.sub.3 ;m, n and q are each independently an integer from zero to four;o is an integer from one to four;r is zero or one;or a pharmaceutically acceptable salt thereof.