Patent ID: 6057304
Filing Date: 2000-05-02
Classification: C07D,C07F

Abstract:
A compound of formula I ##STR6## wherein R.sup.1 is R.sup.2 -substituted 2-propenyl, 2-butenyl, 3-methyl-2-propenyl, 1-propenyl, 1-butenyl or vinyl, R.sup.2 -substituted ethynyl, 1-propynyl, 2-propynyl or 1-butynyl, R.sup.2 -substituted cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl, --(CH.sub.2).sub.n -phenyl --(CH.sub.2).sub.n -naphthyl, --(CH.sub.2).sub.n -biphenylyl or --(CH.sub.2).sub.n -indenyl substituted by R.sup.2 in the aryl or in the alkyl residue, --(CH.sub.2).sub.n -pyrazole or --(CH.sub.2).sub.n -imidazole substituted by R.sup.2 in the hetaryl residue , or --(CH.sub.2).sub.n -pyrazine, --(CH.sub.2).sub.n -pyridine, --(CH.sub.2).sub.n -pyrimidine, --(CH.sub.2).sub.n -pyridazine or --(CH.sub.2)- triazine substituted by R.sup.2 in the hetaryl or alkyl residue,R.sup.4 is hydrogen, R.sup.2 -substituted methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, heptyl, octyl, nonyl or decyl, R.sup.2 -substituted 2-propenyl, 2-butenyl, 3-methyl-2-propenyl, 1-propenyl, 1-butenyl or vinyl, R.sup.2 -substituted ethynyl, 1-propynyl, 2-propynyl or 1-butynyl, R.sup.2 -substituted cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl, --(CH.sub.2).sub.n -phenyl --(CH.sub.2).sub.n - naphthyl, --(CH.sub.2).sub.n -biphenylyl or --(CH.sub.2).sub.n -indenyl substituted by R.sup.2 in the aryl or in the alkyl residue, or --(CH.sub.2).sub.n -pyrazole, --(CH.sub.2).sub.n -imidazole, --(CH.sub.2).sub.n -pyrazine, --(CH.sub.2).sub.n -pyridine, --(CH.sub.2).sub.n -pyrimidine, --(CH.sub.2).sub.n -pyridazine or --(CH.sub.2)-triazine substituted by R.sup.2 in the hetaryl or alkyl residue,R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each independently hydrogen, halogen, nitro, NR.sup.9 R.sup.10, NHCOR.sup.11, SO.sub.2 R.sup.12, C.sub.3-7 -cycloalkyloxy, COR.sup.13, cyano, CF.sub.3, C.sub.1-6 -alkyl, C.sub.1-4 -alkoxy, or imidazolyl optionally substituted by cyano, C.sub.1-4 -alkyl or --COO--C.sub.1-6 -alkyl,R.sup.2 is --PO--XY and is present once or twice,n is 0, 1, 2, 3, 4 or 5,X and Y are each independently hydroxy, C.sub.1-6 -alkoxy, C.sub.1-4 -alkyl or NR.sup.9 R.sup.10,R.sup.9 and R.sup.10 are each independently hydrogen, C.sub.1-4 -alkyl, or jointly with the nitrogen form a saturated 5- or 6-membered heterocycle which is piperidine, pyrrolidine, morpholine, thiomorpholine or piperazine,R.sup.11 is C.sub.1-6 -alkyl or phenyl,R.sup.12 is hydrogen, C.sub.1-4 -alkyl, NH.sub.2, N(C.sub.1-4 -alkyl).sub.2, andR.sup.13 is hydroxy, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl or NR.sup.9 R.sup.10,or a tautomer, optical isomer, or a racemic or enantiomeric mixture thereof, or a physiologically acceptable salt thereof.