Patent ID: 6121323
Filing Date: 2000-09-19
Classification: C07C,Y10S

Abstract:
A pharmaceutical composition comprising(i) a pharmaceutically acceptable vehicle; and(ii) a therapeutically effective amount of a compound of the formula (I) ##STR35## or a pharmaceutically acceptable salt thereof, wherein M is selected from the group consisting of hydrogen, a pharmaceutically acceptable cation, and a pharmaceutically acceptable metabolically cleavable group;R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen and C.sub.1-6 straight or branched chain alkyl;R.sub.3 and R.sub.4 are independently selected from the group consisting of C.sub.1-14 straight or branched chain alkyl optionally substituted by a group selected from halogen, nitro, hydroxyl, carboxyl and amino, and optionally interrupted by --O--, --S(O).sub.0-2 --, --NR-- wherein R is as defined below, or --CO--; and arylalkyl wherein the alkyl group is straight or branched chain and has from one to eight carbon atoms and the aryl group is phenyl optionally substituted with one or more substituents selected from the group consisting of C.sub.1-6 straight or branched chain alkyl and halogen;A is selected from the group consisting of:(a) phenylene optionally substituted with one or more substituents selected from the group consisting of C.sub.1-6 straight or branched chain alkyl and halogen;(b) naphthalene optionally substituted with one or more substituents selected from the group consisting of C.sub.1-6 straight or branched chain alkyl and halogen; ##STR36## wherein each R.sub.7 and R.sub.8 is independently selected from the group consisting of hydrogen, C.sub.1-3 straight or branched chain alkyl, C.sub.1-3 straight or branched chain alkoxy, and halogen;m is 1 or 2;n is 1 or 2; andB is selected from the group consisting of(i) a carbon-carbon bond,(ii) oxy,(iii) thio,(iv) sulfone,(v) carbonyl, ##STR37## wherein R is selected from the group consisting of hydrogen and C.sub.1-3 straight or branched chain alkyl,(vii) --(CH.sub.2).sub.p -- wherein p is an integer from 1 to 14, and ##STR38## wherein R.sub.9 and R.sub.10 are independently selected from the group consisting of hydrogen, C.sub.1-3 straight or branched chain alkyl, C.sub.3-6 cycloalkyl; and trifluoromethyl.