Patent ID: 7767090
Filing Date: 2010-08-03
Classification: G01N

Abstract:
1. The process of maintaining compression on a media bed in a chromatography system, said system comprising a column having an inlet and containing a media bed through which a fluid is adapted to flow; an adjustable bed support movable in said column and adapted to exert a force on said media bed; a sensor for determining the pressure of said fluid entering said column; a load cell for measuring the force exerted on said adjustable bed support; and an actuator for moving said adjustable bed support in response to the force measured by said load cell, said process comprising the steps of: using said load cell to measure said force exerted on said adjustable bed support; using said sensor to measure the pressure of said fluid; calculating compression force on said media bed, based on measurements from said load cell and said sensor; comparing said calculated compression force to an optimal compression force; and using said actuator to move said adjustable bed support based on said comparison.