Patent ID: 6489291
Filing Date: 2002-12-03
Classification: A61K,A61P,C07C

Abstract:
A method for retarding aging of the skin or rejuvenating the skin comprising applying to a surface of skin in need thereof, a topical skin composition comprising a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or â€”CH(R6)COOR7, wherein R6 represents a hydrogen atom or a C1-6 alkyl group, and R7 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, or an aralkyl group;R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a C1-6 alkyl group or a phenyl group; R4 represents a hydrogen atom or a C1-6 alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents â€”SO3H or â€”COOR8, wherein R8 represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkenyl group, or an aralkyl group; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.