Patent ID: 8748480
Filing Date: 2014-06-10
Classification: A61K,A61P,G01N

Abstract:
1. A method for ameliorating or treating a disease or condition in a subject in need thereof, wherein the disease or condition involves at least one G protein βγ subunit activity, the method comprising administering to the subject a therapeutically effective amount of a therapeutically acceptable composition comprising a compound that binds to at least one amino acid residue of the protein interaction site of the G protein β subunit, wherein the protein binding site comprises at least one amino acid selected from the group consisting of Lys57, Tyr59, Trp99, Val100, Met101, Leu117, Tyr145, Asp186, Met188, Asp228, Asn230, Asp246, and Trp332 of SEQ ID NO:3 or 4, wherein the compound is a compound of Formula III or a salt thereof: wherein the disease or condition is opioid tolerance; whereby the disease or condition in the subject is ameliorated or treated in the subject.