Patent ID: 6399604
Filing Date: 2002-06-04
Classification: C07D

Abstract:
A pharmaceutical composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein: X is hydrogen, halogen, â€”OR1, C1-C6 alkyl optionally substituted with up to three groups selected independently from halogen and hydroxy, and â€”NR2R3; X is phenyl, naphthyl, 1-(5,6,7,8-tetrahydro)naphthyl or 4-(1,2-dihydro)indenyl, pyridinyl, pyrimidyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, benzofuranyl, or benzothienyl, each of which is optionally substituted with up to three groups selected from halogen, C1-C6 alkyl, C1-C4 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl and trifluoromethoxy; or X represents a carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen, where the X carbocyclic group is optionally substituted with one or more groups selected from halogen, C1-C6 alkoxy, mono- or di (C1-C6)alkylamino, sulfonamide, aza(C3-C7) cycloalkyl, C3-C7 cycloalkylthio, C1-C6 alkylthio, phenylthio, or a heterocyclic group; Y is lower alkyl having 1-8 carbon atoms optionally substituted with up to two groups selected from halogen, C3-C7 cycloalkyl, C1-C6 alkoxy, mono- or di(C1-C6)alkylamino, sulfonamide, aza(C3-C7) cycloalkyl, C3-C7 cycloalkylthio, C1-C6 alkylthio, phenylthio, a heterocyclic group, â€”OR4,â€”NR5R6, SR7, and optionally substituted aryl; or Y is a carbocyclic group having from 3-7 members atoms, where up to three of which members are optionally hetero atoms selected from oxygen and nitrogen and where any member of the Y carbocyclic group is optionally substituted with halogen, â€”OR4, â€”NR5R6, SR7, aryl or a heterocyclic group; R1 is hydrogen, lower alkyl having 1-6 carbon atoms, or cycloalkyl having 3-7 carbon atoms, where each alkyl is optionally substituted with â€”OR4, or â€”NR5R6; R2 and R3 are the same or different and represent hydrogen, lower alkyl optionally mono- or disubstituted with alkoxy, aryl, or halogen; aryl or aryl(C1-C6)alkyl where each aryl is optionally substituted with up to three groups selected from halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, or mono- or di (C1-C6) alkylamino; cycloalkyl having 3-7 carbon atoms optionally mono or disubstituted with halogen, or alkoxy; or â€”SO2R8; R4 is as defined for R1; R5 and R6 carry the same definitions as R2 and R3, respectively; R7 is hydrogen, lower alkyl having 1-6 carbon atoms, or cycloalkyl having 3-7 carbon atoms; and R8 is lower alkyl having 1-6 carbon atoms, cycloalkyl having 3-7 carbon atoms, or optionally substituted phenyl.