Patent ID: 6646135
Filing Date: 2003-11-11
Classification: C07C,C07D,Y02P

Abstract:
A continuous process for enantioselective hydrogenation of a substrate containing an alpha ketocarbonyl compound comprising the steps of:(i) contacting in a reactor charged with a platinum catalyst a substrate solution, a modifier for the platinum catalyst and hydrogen at a temperature of from about âˆ’20Â° C. to about 100Â° C. and at a pressure from about 2 bar to about 150 bar to convert the alpha ketocarbonyl compound to an alpha hydroxy carbonyl compound; (ii) continuously feeding the substrate to the reactor; (iii) continuously feeding modifier into the reactor; (iv) continuously feeding hydrogen to the reactor; (v) continuously discharging a reaction product from the reactor; and (vi) recovering the alpha hydroxy carbonyl compound from the reaction product.