Patent ID: 6559163
Filing Date: 2003-05-06
Classification: A61P,C07D

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof wherein:R1 at each occurrence is independently selected from the group consisting of hydrogen, halogen, cyano, haloalkyl, haloalkoxy, hydroxy, amino, â€”NH(R2), â€”N(R2)2, nitro, C1-C8 alkoxy and R2; R2 at each occurrence is independently selected from the group consisting of C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, and C5-C10 cycloalkynyl; at least one of Ra or Rb is selected from halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, phenyl substituted with 0-3 R6, â€”XR7, Y, R2, â€”OR2 â€”NH(R2) and â€”N(R2)2, wherein each R2 group is independently substituted with from 0 to 2 R6; the remaining Ra and Rb at each occurrence are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, â€”OR2 wherein R2 is substituted with 0-2 R6, â€”NH(R2) wherein R2 is substituted with 0-2 R6, â€”N(R2)2 wherein the R2 groups are independently substituted with 0-2 R6, R2 wherein the R2 group is substituted with 0-2 R6, phenyl substituted with 0-3 R6, â€”XR7, and Y; W represents phenyl, thienyl, or pyridyl, wherein each is substituted with Rd, Rdâ€², and Rdâ€³ which are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, R2 substituted with 0-2 R6, â€”OR2 substituted with 0-2 R6, â€”NH(R2) wherein R2 is substituted with 0-2 R6, phenyl substituted with 0-3 R6, â€”XR7, Y, and â€”N(C1-C6 alkyl1) (C1-C6 alkyl2) where each alkyl is independently substituted with 0-2 R6, or alkyl1, alkyl2 and the nitrogen to which they are attached form a heterocycloalkyl ring substituted with 0-2 R6; X at each occurrence is independently selected from the group consisting of â€”CH2â€”, â€”CHR8â€”, â€”Oâ€”, â€”S(O)mâ€”, â€”NHâ€”, â€”NR8â€”, â€”C(O)â€”, â€”C(O)Oâ€”, â€”C(O)NHâ€”, â€”C(O)NR8â€”, â€”S(O)mNHâ€”, â€”S(O)mNR8â€”, â€”NHC(O)â€”, â€”NR8C(O)â€”, â€”NHS(O)mâ€”, and â€”NR8S(O)mâ€”; wherein m is 0, 1, or 2; R6 at each occurrence is independently selected from the group consisting of halogen, hydroxy, R2, â€”OR2, â€”NH(R2), â€”N(R2)2, â€”NHâ€”(R2â€”Y), â€”N(R2)â€”(R2â€”Y), â€”NHâ€”(R2â€”N(R2) (R2)), â€”N(R2)â€”(R2â€”N(R2) (R2)), morpholinyl, pyrrolidinyl, piperidinyl, thiomorpholinyl, piperazinyl, homopiperazinyl, â€”S(O)m(R2), haloalkyl, haloalkoxy, â€”CO(R2), â€”CONH(R2), CON(R2)2, â€”XR7, and Y; wherein m is 0, 1, or 2; R7 and R8 at each occurrence independently carry the same definition as R2, wherein R7 and R8 are substituted with 0, 1, 2, 3, or 4 substituents selected from the group consisting of oxo, hydroxy, halogen, amino, cyano, nitro, haloalkyl, haloalkoxy, â€”O(R2), â€”NH(R2), â€”N(R2)2, â€”NHC(O) (R2), â€”N (R2)C(O)(R2), â€”NHS(O)m(R2), â€”S(O)m(R2), â€”S(O)mNH(R2), and â€”S(O)mN(R2)2, and Yâ€²; wherein m is 0, 1, or 2; and Y and Yâ€² at each occurrence are independently selected from 5- to 8-membered carbocycles and heterocycles, which are saturated, partially unsaturated, or aromatic, and contain zero, one or two heteroatoms selected from N, O, and S, and which carbocycles and heterocycles may be further substituted with 1, 2, 3, or 4 substituents selected from the group consisting of halogen, oxo, hydroxy, amino, nitro, cyano, R2, â€”OR2, â€”NH(R2), â€”N(R2)2, and â€”S(O)a(R2); wherein a is 0, 1, or 2.