Patent ID: 6362196
Filing Date: 2002-03-26
Classification: A61K,A61P

Abstract:
A method to treat pain, or migraine, said method comprising a step ofadministering to one in need of such treatment an effective amount of an NMDA NR2B antagonist described by formula (I): or a salt or prodrug thereof, whereinE represents â€”CH2â€” or â€”CH2CH2â€”; R represents hydrogen or C1-6alkyl; Q represents a moiety of formula Qa, Qb, or Qc: in which the broken line represents an optional chemical bond;R1 represents hydrogen, or an optionally substituted C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, aryl, aryl(C1-6)alkyl, aryl(C1-6)alkoxy, aryl(C2-6)alkenyl, aryl(C2-6)alkynyl, C3-7heterocycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-6)alkyl, heteroaryl(C2-6)alkenyl or heteroaryl(C2-6)alkynyl group; R2 represents an aryl, aryl(C1-6)alkyl, aryloxy(C1-6)alkyl, aryl(C1-6)alkyl, aryl(C1-6)alkoxy, aryl(C2-6)alkenyl, aryl(C2-6)alkynyl, heteroaryl or heteroaryl(C2-6)alkenyl group, any of which groups may be optionally substituted on the aromatic moiety; R3, R4, and R5 independently represent hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, â€”ORa, â€”SRa, â€”SORa, â€”SO2Ra, â€”SO2NRaRb, â€”NRaRb, â€”NRaCORb, â€”NRaCO2Rb, â€”CORa, â€”CO2Ra, or â€”CONRaRb; Z represents â€”CH2â€” or â€”CH2CH2â€”; R6 represents hydrogen, C1-6alkyl, C1-6alkoxy, aryl, aryl(C1-6)alkyl, or halogen; and Ra and Rb independently represent hydrogen, hydrocarbon, or a heterocyclic group.