Patent ID: 6271252
Filing Date: 2001-08-07
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula I: ##STR19##or a pharmaceutically acceptable salt thereof wherein:X is --C(O)OR.sup.d ;Y is --S(O).sub.2 --;R is a saturated or partially saturated monocyclic or bicyclic ring having 0 heteroatoms, optionally benzo-fused and optionally substituted with from 1-4 groups selected from R.sup.b ;R.sup.1 is Cy optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.2 and R.sup.3 are each hydrogen, orR.sup.2 and R.sup.3 together with the atoms to which they are attached form a pyrrolidine ring, wherein said ring may be isolated or benzo-fused, and optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.4 is1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) aryl, or6) aryl C.sub.1-10 alkyl,wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a, and aryl is optionally substituted with one to four substituents independently selected from R.sup.b ; orR.sup.3, R.sup.4 and the carbon to which they are attached form a 3-7 membered carbocyclic ring;R.sup.5 is1) hydrogen,2) C.sub.1-10 alkyl,3) Cy, or4) Cy-C.sub.1-10 alkyl,wherein alkyl is optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ;R.sup.6 is selected from the group consisting of:1) hydrogen,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy-(Cy.sup.1).sub.p,6) Cy-(Cy.sup.1).sub.p -C.sub.1-10 alkyl,7) Cy-(Cy.sup.1).sub.p -C.sub.2-10 alkenyl,8) Cy-(Cy.sup.1).sub.p -C.sub.2-10 alkynyl,alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from R.sup.a ; and Cy and Cy.sup.1 are optionally substituted with one to four substituents independently selected from R.sup.b ; orR.sup.6 together with the carbon atom to which it is attached and another carbon atom of R form a carbocyclic ring having from 5-8 members optionally substituted with R.sup.b ;R.sup.7 is1) hydrogen2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl,5) Cy,6) Cy-C.sub.1-10 alkyl,7) Cy-C.sub.2-10 alkenyl,8) Cy-C.sub.2-10 alkynyl,9) C.sub.1-10 alkoxy,10) Cy-O,11) Cy-C.sub.1-10 alkoxy,12) --S(O).sub.m R.sup.d,13) --SR.sup.d,14) --S(O).sub.2 OR.sup.d,15) --S(O).sub.m NR.sup.d R.sup.e,16) hydroxy,17) --NR.sup.d R.sup.e,18) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,19) --OC(O)R.sup.d,20) --CN,21) --C(O)NR.sup.d R.sup.e,22) --NR.sup.d C(O)R.sup.e,23) --OC(O)NR.sup.d R.sup.e,24) --NR.sup.d C(O)OR.sup.e, or25) --NR.sup.d C(O)NR.sup.d R.sup.e,wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from R.sup.a, and Cy is optionally substituted with one to four substituents independently selected from R.sup.b ; orR.sup.7 together with the carbon atom to which it is attached and another carbon atom of R form a carbocyclic ring having from 5-8 members optionally substituted with R.sup.b ; orR.sup.6 and R.sup.7 together represents a double bond between the carbon atoms to which they are attached;R.sup.a is1) --CF.sub.3 ;2) --OR.sup.d,3) --NO.sub.2,4) halogen5) --S(O).sub.m R.sup.d,6) --SR.sup.d,7) --S(O).sub.2 OR.sup.d,8) --S(O).sub.m NR.sup.d R.sup.e,9) --NR.sup.d R.sup.e,10) --O(CR.sup.f R.sup.g).sub.n NR.sup.d R.sup.e,11) --C(O)R.sup.d,12) --CO.sub.2 R.sup.d,13) --CO.sub.2 (CR.sup.f R.sup.g).sub.n CONR.sup.d R.sup.e,14) --OC(O)R.sup.d,15) --CN,16) --C(O)NR.sup.d R.sup.e,17) --NR.sup.d C(O)R.sup.e,18) --OC(O)NR.sup.d R.sup.e,19) --NR.sup.d C(O)OR.sup.e, or20) --NR.sup.d C(O)NR.sup.d R.sup.e ;21) --CR.sup.d (N--OR.sup.e), or22) Cy optionally substituted with a group independently selected from R.sup.c ;R.sup.b is1) a group selected from R.sup.a,2) C.sub.1-10 alkyl,3) C.sub.2-10 alkenyl,4) C.sub.2-10 alkynyl, or5) Cy-C.sub.1-10 alkyl,wherein alkyl, alkenyl, alkynyl, and Cy are optionally substituted with a group independently selected from R.sup.c ;R.sup.c is1) halogen,2) amino,3) carboxy,4) C.sub.1-4 alkyl,5) C.sub.1-4 alkoxy,6) aryl,7) aryl C.sub.1-4 alkyl, or8) aryloxy;R.sup.d and R.sup.e are independently selected from hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, Cy and Cy-C.sub.1-10 alkyl, wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R.sup.c ;R.sup.f and R.sup.g are independently selected from hydrogen, C.sub.1-10 alkyl, Cy and Cy-C.sub.1-10 alkyl;m is 0, 1 or 2;n is an integer from 1 to 10;p is 0 or 1.