Patent ID: 7807145
Filing Date: 2010-10-05
Classification: A61K,C12N

Abstract:
1. A method of inducing addition of medium spiny neurons in a post-natal or adult mammalian subject's brain comprising: providing a nucleic acid construct encoding a neurotrophic factor selected from the group consisting of neurotrophin-4 (NT-4) and brain-derived neurotrophic factor, and a nucleic acid construct encoding a bone morphogenetic protein inhibitor, wherein the nucleic acid constructs are in viral vectors, and injecting said viral vectors into the post-natal or adult mammalian subject's lateral ventricles to infect the mammalian subject's ventricular wall under conditions effective to express the neurotrophic factor and bone morphogenetic protein inhibitor and to induce addition of medium spiny neurons in any one or all of the caudate nucleus and the putamen of the mammalian subject.