Patent ID: 8877754
Filing Date: 2014-11-04
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of the formula I wherein Ar 1 is selected from the group consisting of: wherein R A is selected from the group consisting of F, Cl, Br, I, CN, NO 2 , C 1-6 -alkyl, C 3-10 -carbocyclyl-, C 3-10 -carbocyclyl-C 1-3 -alkyl, C 1-6 -alkyl-O—, C 3-6 -alkenyl-O—, C 3-6 -alkynyl-O—, C 1-4 -alkyl-S—, C 3-10 -carbocyclyl-O—, C 3-10 -carbocyclyl-C 1-3 -alkyl-O—, C 1-4 -alkyl-C(═O)—, R N1 R N2 N—, R N1 R N2 N—C 2-3 -alkyl-O—, R N1 R N2 N—C(═O)—, HO—C(═O)—, C 1-4 -alkyl-O—C(═O)—, heterocyclyl, heterocyclyl-C 1-3 -alkyl, heterocyclyl-O—, heterocyclyl-C 1-3 -alkyl-O—, heterocyclyl-C(═O)—, phenyl, phenyl-O—, phenyl-C 1-3 -alkyl-, phenyl-C 1-3 -alkyl-O—, heteroaryl, heteroaryl-C 1-3 -alkyl, heteroaryl-O— and heteroaryl-C 1-3 -alkyl-O—; wherein each heterocyclyl is selected from the group consisting of azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N—C 1-4 -alkyl-piperazin-1-yl, N—C 1-4 -alkylsulfonyl-piperazin-1-yl, morpholinyl, dihydroisoindolyl, oxetanyl, tetrahydrofuranyl and tetrahydropyranyl, or from the group consisting of wherein carbocyclyl is selected from C 3-6 -cycloalkyl; and wherein in each carbocyclyl, pyrrolidinyl and piperidinyl a CH 2 -group is optionally replaced with —C(═O)— or —C(═CR Alk 2 )—; and wherein each heteroaryl is selected from the group consisting of pyrrolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, furanyl, oxazolyl, isoxazolyl, pyrazolyl, thiazolyl, triazolyl, tetrazolyl, indazolyl, benzofuranyl, indolyl and quinolinyl; and wherein each carbocyclyl or heterocyclyl are optionally substituted with one or more C 1-3 -alkyl, which may be substituted as defined hereinafter; and wherein each alkyl, carbocyclyl and heterocyclyl are optionally substituted with one or more substituents selected from F; and wherein each alkyl, carbocyclyl and heterocyclyl are optionally substituted with one or two substituents R C ; and wherein each carbocyclyl and heterocyclyl are optionally substituted with phenyl or pyridyl; and wherein each phenyl and heteroaryl group is optionally substituted with one or more substituents L; R C is selected from the group consisting of F, Cl, Br, CN, OH, C 1-4 -alkyl-O—, C 3-7 -cycloalkyl-O—, C 3-7 -cycloalkyl-C 1-3 -alkyl-O—, H 2 N—, (C 1-4 -alkyl)NH—, (C 1-4 -alkyl) 2 N—, C 1-4 -alkyl-C(═O)—, C 1-4 -alkyl-S(═O) 2 —, HO—C(═O)—, C 1-4 -alkyl-O—C(═O)—, H 2 N—C(═O)—, (C 1-4 -alkyl)HN—C(═O)— and (C 1-4 -alkyl) 2 N—C(═O)—, wherein each alkyl or cycloalkyl is optionally substituted with one or more substituents selected from F and OH; and R N1 is selected from the group consisting of H, C 1-6 -alkyl, C 3-10 -carbocyclyl, C 3-10 -carbocyclyl-C 1-3 -alkyl, C 3-6 -alkenyl, C 3-6 -alkynyl, heterocyclyl, heterocyclyl-C 1-3 -alkyl, aryl, aryl-C 1-3 -alkyl, heteroaryl and heteroaryl-C 1-3 -alkyl, wherein each carbocyclyl and heterocyclyl is optionally substituted with one or more C wherein in each carbocyclyl and heterocyclyl a —CH wherein each alkyl, carbocyclyl and heterocyclyl is optionally substituted with one or more substituents R wherein each aryl and heteroaryl group is optionally substituted with one or more substituents L, R N2 is selected from the group consisting of H and C 1-6 -alkyl; and R Alk is selected from the group consisting of H and C 1-6 -alkyl which may be substituted with one or more F atoms; and Ar 2 is optionally substituted with one or more substituents L; and L is selected from the group consisting of F, Cl, Br, CN, OH, C 1-4 -alkyl-, C 1-4 -alkyl-O—, C 1-4 -alkyl-S—, C 1-4 -alkyl-S(═O) 2 —, H 2 N—, (C 1-4 -alkyl) 2 N— and heterocyclyl, wherein each alkyl is optionally substituted with one or more F-atoms and/or with a substituent selected from OH, C 1-3 -alkyl-O— and CN; and X is selected from the group consisting of: and Y is —C(═O)—; T 1 is selected from the group consisting of H, C 3-7 -cycloalkyl, C 3-7 -cycloalkyl-C 1-3 -alkyl, phenyl, phenyl-C 1-3 -alkyl, heteroaryl and heteroaryl-C 1-3 -alkyl, wherein each cycloalkyl may be optionally substituted with one or more C wherein each alkyl and cycloalkyl may be optionally substituted with one or more substituents R wherein heteroaryl is selected from the group consisting of pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl and thiadiazolyl; and wherein each phenyl and heteroaryl group may be optionally substituted with one or more substituents L; and T 2 is selected from the group consisting of H and C 1-6 -alkyl; or a salt thereof.