Patent ID: 8772260
Filing Date: 2014-07-08
Classification: A61P,C12N

Abstract:
1. A method of treating hypertrophic scarring, comprising administering to a subject in need of treatment for hypertrophic scarring a therapeutically effective amount of a composition comprising a compound which comprises a modified oligonucleotide consisting of 12-30 linked nucleosides, at least a 12 nucleobase sequence portion of which is present within the nucleobase sequence set forth in SEQ ID NO: 39, wherein the modified oligonucleotide comprises: (a) a gap segment consisting of linked deoxynucleosides; (b) a 5′ wing segment consisting of linked modified nucleosides; and (c) a 3′ wing segment consisting of linked modified nucleosides; wherein the gap segment is positioned between the 5 wing segment and the 3′ wing segment, and wherein each modified nucleoside within each wing segment comprises a modified sugar.