Patent ID: 6458798
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A pyrimidine compound of the formula (1) or its salt wherein R1 is a formula (2) whereinring A is substituted or unsubstituted C3-10 cycloalkane, substituted or unsubstituted C5-10 cycloalkene, substituted or unsubstituted C7-10 bicycloalkane, or substituted or unsubstituted heterocyclic ring having an O atom or a S atom as a heteroatom, and said S atom may form sulfinyl or sulfonyl together with one or two oxygen atoms, and R4 is straight or branched C1-10 alkyl, C2-6 alkenyl, C3-6 alkinyl, C3-6 cycloalkyl, C4-10 cycloalkyl-alkyl, or OR8, wherein R8 is straight or branched C-1-10 alkyl, C3-6 alkenyl, C3-6 alkinyl, C3-6 cycloalkyl or C4-10 cycloalkyl-alkyl, or R1 is a formula (3) whereinR5 is straight or branched C2-10 alkyl; C2-6 alkenyl; C3-6 alkinyl; straight or branched C1-10 alkyl substituted by hydroxy, halogen atom or C1-4 alkoxy; C3-8 cycloalkyl; a 5 to 7 membered saturated heterocyclic ring having one or two oxygen atoms as heteroatoms; or C(&boxH;O)R9, wherein R9 is straight or branched C1-10 alkyl, C2-6 alkenyl, C3-6 alkinyl, C3-6 cycloalkyl, C4-10 cycloalkyl-alkyl, or OR10, wherein R10 is straight or branched C1-10 alkyl, C2-6 alkenyl, C3-6 alkinyl, C3-6 cycloalkyl or C4-10 cycloalkyl-alkyl, R6 is a hydrogen atom, straight or branched C-1-10 alkyl, C6-10 aryl, halogen atom, C6-10 aryl substituted by C1-4 alkoxy or C1-4 alkyl, carbamoyl, or hydroxymethyl, and R7 is a hydrogen atom, or straight or branched C1-10 alkyl, and R2 and R3 taken together are C3-5 alkylene or said alkylene in which methylene is substituted by an O atom.