Patent ID: 6011146
Filing Date: 2000-01-04
Classification: A61K,A61P,C07K,Y02A

Abstract:
A recombinant DNA molecule comprising a DNA sequence encoding an altered MHC Class I determinant;wherein said altered MHC Class I determinant comprises a polypeptide comprising .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, and .beta..sub.2 -microglobulin domains;wherein the .alpha..sub.3 domain has a carboxyl terminus, and the .beta..sub.2 -microglobulin domain has an amino terminus covalently linked to said carboxyl terminus by a spacer;wherein said polypeptide contains a binding site for an antigen that may be associated with the polypeptide, and when associated, the polypeptide and the antigen together are recognizable by a mammalian T cell receptor; andwherein said spacer is a nucleotide sequence encoding a polypeptide.