Patent ID: 7585657
Filing Date: 2009-09-08
Classification: A61K,C12N

Abstract:
1. An influenza viral vector, comprising influenza virus incorporation sequences, which vector comprises: sequences corresponding to the 3′ noncoding region of influenza virus HA vRNA and HA coding sequences which include 3′ HA incorporation sequences, a nucleic acid segment for a heterologous open reading frame which encodes a gene product, and HA coding sequences which include 5′ HA incorporation sequences and the 5′ noncoding region of HA vRNA, wherein the HA coding sequences which include 3′ HA incorporation sequences include at least 3 nucleotides of 5′ HA coding sequence and the HA coding sequences which include the 5′ HA incorporation sequences have no more than 1011 nucleotides of 3′ HA coding sequences.