Patent ID: 6521445
Filing Date: 2003-02-18
Classification: C07D,C12P

Abstract:
A method for obtaining an organic solution comprising an optically active diastereomer of a trans-glycidic acid ester compound of the formula I in which R1 is a phenyl or substituted phenyl and OR2 is a group derived from an alcohol, which method comprises: (a) preparing an organic solution comprising a diastereomer of a compound of formula I dissolved in a water-immiscible organic solvent, said diastereomer present as a mixture of a first and a second enantiomer; and (b) contacting said organic solution of said diastereomer with an aqueous mixture comprising water and a suitable hydrolytic enzyme, said enzyme being capable of catalyzing the enantioselective hydrolysis of said first enantiomer, under conditions effective to provide an organic solution enriched in said second enantiomer.