Patent ID: 7728136
Filing Date: 2010-06-01
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (I): wherein Ar is naphthyl optionally substituted with one to four substituents independently selected from fluoro, chloro, trifluoromethyl, methoxy, cyano and nitro; quinolyl; isoquinolyl; quinazolyl; 6-hydroxy-8-quinolyl; benzoisothiazolyl or an oxide or dioxide thereof, each optionally substituted with one or more substituents independently selected from fluoro, chloro, trifluoromethyl, methoxy, cyano, and nitro; benzothiazolyl; benzothiadiazolyl; benzotriazolyl; benzoxazolyl; benzoxozolonyl; indolyl; indanyl optionally substituted by one or two fluoro; 3-indazolyl optionally substituted by 1-trifluoromethylphenyl; or phthalazinyl; n is 1 or 2; and X and Y together with the phenyl to which they are attached, form a ring system selected from quinolyl; 2-hydroxyquinolyl; benzothiazolyl; 2-aminobenzothiazolyl; benzoisothiazolyl; indazolyl; 3-hydroxyindazolyl; indolyl; spiro[cyclopentane-1,3′-indolinyl]; and oxindolyl; wherein the ring system may optionally be substituted with one to three substituents independently selected from (C1-C3) alkyl, or with one substituent selected from chloro, fluoro; benzoxazolyl; 2-aminobenzoxazolyl; benzoxozolonyl; 2-aminobenzoxazolinyl; benzothiazolonyl; benzoimidazolonyl; or benzotriazolyl; and phenyl optionally substituted with one chloror or fluoro; the process comprises reacting a monosubstituted piperazine of the formula II wherein Ar is as defined above, with an alkyl halide containing compound of the formula III wherein n, X and Y are as defined above and Hal is fluoro, chloro, bromo or iodo, by heating in solvent free conditions or, optionally, as suspension in minimum quantity of non-aqueous suspending liquid, in presence of an alkali metal halide catalyst and a neutralizing agent.