Patent ID: 8927493
Filing Date: 2015-01-06
Classification: A61K,A61P,C07K

Abstract:
1. A method for promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue consisting essentially of administering the following (1) or (2) to a patient with tendon-bone junction tissue injury or ligament-bone junction tissue injury: (1) a Hepatocyte Growth Factor (HGF) protein having an amino acid sequence at least 95% homologous to the amino acid sequence represented by SEQ ID NO: 3, and having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, or (2) a formulation consisting of (1), and at least one member selected from the group consisting of aqueous solvent, tonicity agent, buffer solution, preservative, thickener, stabilizer, pH adjuster, solubilizing agent, oily solvent, propellant, and biodegradable polymer, wherein (1) or (2) is locally applied to an interface region where the bone is in contact with the tendon or ligament, or a space between the bone and the tendon or ligament.