Patent ID: 6461591
Filing Date: 2002-10-08
Classification: A61K,Y10S

Abstract:
An inhalable medicinal aerosol formulation comprising an effective amount of a pharmaceutically active compound and a pressure-liquified homogeneous propellant mixture, comprising carbon dioxide and hydrofluoroalkane of formulaCxHyFzâ€ƒâ€ƒ(I) in which x is the number 1, 2 or 3, y and z are each an integer &gE;1 and y+z=2x+2, the carbon dioxide being present in an amount of from 0.01 to 2% by weight, based on the total weight of the formulation, wherein the hydrofluoroalkane of the formula I is selected from the group consisting of 1,1,1,2-tetrafluoroethane; 1,1,1,2,3,3,3-heptafluoropropane; and 1,1,1,2-tetrafluoroethane in the presence of 1,1,1,2,3,3,3-heptafluoropropane, wherein the inhalable medicinal aerosol formulation is contained in a metered dose inhaler.