Patent ID: 6172228
Filing Date: 2001-01-09
Classification: A61P,C07D

Abstract:
A process for preparing a piperazinesulfonamide compound represented by the formula (III): ##STR12##wherein R.sup.1 is hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group or amino group; R.sup.2 is a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group, amino group, 2-pyridyl group, 3-pyridyl group and 4-pyridyl group; each of R.sup.3 and R.sup.4 is independently hydrogen atom, a straight or branched chain allyl group having 1 to 6 carbon atoms, a hydroxyalkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group and amino group; and Y is an alkylene group having 1 to 12 carbon atoms, comprising:reacting a piperazine compound represented by the formula (I): ##STR13##wherein R.sup.1 and R.sup.2 are as defined above, with a halogenoalkylsulfonamide compound represented by the formula (II): ##STR14##wherein R.sup.3, R.sup.4 and Y are as defined above; and X is chlorine atom, bromine atom or iodine atom, in the presence of an organic base selected from the group consisting of N-ethyldiiso-propylamine, N-ethylmorpholine, triethylamine and 2,4,6-trimethylpyridine, and in the absence of a solvent.