Patent ID: 6140347
Filing Date: 2000-10-31
Classification: C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt or prodrug thereof: ##STR33## wherein Z represents hydrogen, halogen, cyano, nitro, trifluoromethyl, --OR.sup.5, --OCOR.sup.5, --OCONR.sup.5 R.sup.6, --OCH.sub.2 CN, --OCH.sub.2 CONR.sup.5 R.sup.6, --SR.sup.5, --SOR.sup.5, --SO.sub.2 R.sup.5, --SO.sub.2 NR.sup.5 R.sup.6, --NR.sup.5 R.sup.6, --NR.sup.5 COR.sup.6, --NR.sup.5 CO.sub.2 R.sup.6, --NR.sup.5 SO.sub.2 R.sup.6, --COR.sup.5, --CO.sub.2 R.sup.5, --CONR.sup.5 R.sup.6, or a group of formula (a), (b), (c) or (d): ##STR34## in which the asterisk * denotes a chiral centre; or Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole;X represents oxygen, sulphur, --NH-- or methylene;Y represents oxygen or sulphur;E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;Q represents a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally substituted in any position by one or more substituents selected from fluoro and hydroxy;T represents nitrogen or CH;U represents nitrogen or C--R.sup.2 ;V represents oxygen, sulphur or N--R.sup.3 ;W represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;M represents the residue of an azetidine, pyrrolidine or piperidine ring;R.sup.1 represents C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, aryl(C.sub.1-6)alkyl or heteroaryl(C.sub.1-6)alkyl, any of which groups may be optionally substituted;R.sup.2, R.sup.3, R.sup.4 and R.sup.7 independently represent hydrogen or C.sub.1-6 alkyl; with the proviso that when M represents the residue of an azetidine or pyrrolidine ring, Q is methylene, W represents a chemical bond, R.sup.7 is C.sub.1-6 alkylR.sup.5 and R.sup.6 independently represent hydrogen, C.sub.1-6 alkyl, trifluoromethyl, phenyl, methylphenyl, or an optionally substituted aryl(C.sub.1-6)alkyl or heteroaryl(C.sub.1-6)alkyl group; or R.sup.5 and R.sup.6, when linked through a nitrogen atom, together represent the residue of an optionally substituted azetidine, pyrrolidine, piperidine, morpholine or piperazine ring; andR.sup.8 represents hydrogen or hydroxy.