Patent ID: 7452987
Filing Date: 2008-11-18
Classification: A61K,A61P,C12N,C12Q,C12Y

Abstract:
1. A nucleic acid molecule comprising a first strand and a second strand, wherein said first strand comprises a first stretch that is complementary to a target nucleic acid, wherein said second strand comprises a second stretch that is the same length as said first stretch and that is complementary to said first stretch, wherein said first strand and said second strand form a double-stranded structure consisting of said first stretch and said second stretch, wherein said first stretch and said second stretch each consist of contiguous alternating single 2′-O-methyl modified and single unmodified ribonucleotides, wherein said 2′-O-methyl modified and unmodified ribonucleotides in each stretch are linked by phosphodiester bonds, wherein each modified ribonucleotide in said first stretch is base paired with a said unmodified ribonucleotide in said second stretch, wherein each modified ribonucleotide in said second stretch is base paired with a said unmodified ribonucleotide in said first stretch, and wherein each stretch consists of 15-23 ribonucleotides.