Patent ID: 6096305
Filing Date: 2000-08-01
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method for suppressing rejection of a grafted syngeneic or allogeneic organ or grafted tissue in a graft recipient, comprising transfecting the organ or tissue to be transplanted with a DNA encoding a soluble IL-17R selected from the group consisting of:(a) a protein comprising amino acids 1 through 322 of SEQ ID NO.: 2;(b) a protein comprising amino acids 1 through 320 of SEQ ID NO.: 10;(c) proteins encoded by DNA molecules which hybridize to DNA's encoding the proteins of (a) or (b) under moderately stringent conditions, and which bind IL-17; and(d) fragments of the proteins of (a), (b) or (c) which encode proteins comprising an extracellular domain of the proteins of SEQ ID NO.:2 or SEQ ID NO.:10, that bind IL-17,and engrafting the organ or tissue in the recipient, wherein the expression of IL-17R by the engrafted organ or tissue results in suppression of rejection.