Patent ID: 6100279
Filing Date: 2000-08-08
Classification: A61K,C07D

Abstract:
A compound of the formula: ##STR65## or pharmaceutically acceptable salts or solvates thereof, wherein: X is a straight chain alkyl group having 1 to 7 carbon atoms or an alkene or alkyne group with 2 to 4 carbon atoms; wherein said alkyl or alkene groups are optionally substituted with up to two R.sup.7 groups;n is 0, 1 or 2m is 2 to 4;p is 0 to 4;Y represents --SO.sub.2 --; --CS--; --CO--; --CONR.sup.5 --; --CO(CH.sub.2).sub.w O-- (with w being 1 to 4); --COO--; --CON(OR.sup.5)--; --C(NR.sup.5)NR.sup.5 --; --SO.sub.2 NR.sup.5 -- or --CSNR.sup.5 --; --CHOR.sup.5 --; --NR.sup.5 CONR.sup.5 --; --NR.sup.5 CO--; --NR.sup.5 --; --OCONR.sup.5 --; --NR.sup.5 C(NR.sup.5)NR.sup.5 --; --NR.sup.5 CSNR.sup.5 ; --NR.sup.5 CS--; --NR.sup.5 SO.sub.2 --; --NR.sup.5 C(O)O--; or --CSNR.sup.5 --;each R.sup.5 independently represents hydrogen, alkyl or benzyl;R.sup.6 is selected from:(1) aryl,(2) heteroaryl,(3) substituted aryl having 1-3 substituents independently selected from of alkyl, halogen, trihalomethyl, CN, NO.sub.2, OR.sup.10 or NR.sup.10 R.sup.11, wherein R.sup.10 and R.sup.11 are independently selected from H, alkyl or trihalomethyl,(4) substituted heteroaryl having 1-3 substituents independently selected from alkyl, halogen, trihalomethyl, CN, NO.sub.2, OR.sup.10 or NR.sup.10 R.sup.11, wherein R.sup.10 and R.sup.11 are as defined above; or(5) substituted heterocyclic having 1-3 substituents independently selected from alkyl trihalomethyl or NR.sup.10 R.sup.1 1, wherein R.sup.10 and R.sup.11 as defined above, said substituents being bound to carbon atoms in the ring such that the total number of substituents in the ring is 1 to 3; and wherein the heterocyclic ring contains substitutable nitrogen atoms, said nitrogen atoms are optionally substituted with lower alkyl;when Y is --SO.sub.2 --, then R.sup.6, in addition to the above groups, also represents alkyl having 1 to 7 carbon atoms or a group --NR.sup.10 R.sup.11 wherein R.sup.10 and R.sup.11 are as defined above;each R.sup.1 is independently selected from hydrogen, alkyl or trihalomethyl;each R.sup.7 is independently selected from hydrogen, alkyl, trihalomethyl, phenyl or benzyl, wherein said phenyl and benzyl are optionally substituted by one to three substituents independently selected from of alkyl, halogen, trihalomethyl, CN, NO.sub.2, OR.sup.10 or NR.sup.10 R.sup.11, wherein R.sup.10 and R.sup.11 wherein R.sup.10 and R.sup.11 as above defined.