Patent ID: 9086405
Filing Date: 2015-07-21
Classification: A01K,G01N

Abstract:
1. A method of inducing reproducible brain ischemia and optionally reperfusion injury in a non-human mammal, the method comprising: exposing a portion of the middle cerebral artery (MCA) located in the area of the rhinal fissure and bifurcation of the MCA to the frontal and parietal cortices in the non-human mammal, temporarily occluding said MCA at a first location, a second location, and a third location to substantially occlude blood flow, wherein: maintaining said occlusion for a time sufficient to induce a focal ischemia in the area of the MCA in the non-human mammal; and, optionally, releasing said occlusion to restore blood flow and maintaining said restored blood flow for a time sufficient to induce a reperfusion injury.