Patent ID: 6566131
Filing Date: 2003-05-20
Classification: A61K,C12N,Y02P

Abstract:
A compound 8 to 50 nucleobases in length targeted to nucleobases 40 through 57, nucleobases 99 through 116, nucleobases 156 through 173, nucleobases 180 through 197, nucleobases 219 through 236, nucleobases 286 through 303, nucleobases 411 through 428, nucleobases 537 through 554, or nucleobases 786 through 803 of a 5â€²-untranslated region, nucleobases 948 through 965, nucleobases 1014 through 1031, nucleobases 1033 through 1050, nucleobases 1080 through 1097, nucleobases 1277 through 1294, nucleobases 1314 through 1331, nucleobases 1427 through 1444, nucleobases 1456 through 1473, nucleobases 1729 through 1746, nucleobases 1945 through 1962, nucleobases 2001 through 2018, nucleobases 2066 through 2083, nucleobases 2162 through 2179, or nucleobases 2326 through 2343 of a coding region of a nucleic acid molecule encoding human Smad6 of SEQ ID NO: 3, wherein said compound specifically hybridizes with one of said regions and inhibits the expression of human Smad6.