Patent ID: 7438926
Filing Date: 2008-10-21
Classification: A61K,Y10S

Abstract:
1. A mechanical device for causing transdermal flux of a therapeutic agent comprising: a patch comprising a microprotrusion array capable of forming disruptions in at least the stratum corneum of the skin in order to form pathways therethrough; and at least one reservoir comprising a first therapeutic agent and at least one anti-healing agent which are different from each other, said at least one reservoir is capable of being placed in agent transmitting relationship with the skin and said pathways, wherein the amount of said at least one anti-healing agent is effective in inhibiting a decrease in therapeutic agent transdermal flux when compared to the transdermal flux of said first therapeutic agent under substantially identical conditions except in the absence of said at least one anti-healing agent; wherein said anti-healing agent is provided in an amount sufficient to achieve a flux decrease of less than a 2-fold between 1 and 24 hours.