Patent ID: 6831081
Filing Date: 2004-12-14
Classification: A61P,C07D

Abstract:
A compound of a compound of formula I: its enantiomeric, diastereomeric, or tautomeric isomer thereof, or a pharmaceutically acceptable salt thereof wherein,G is phenyl substituted with from one (1) to five (5) R1 substituents; each R1 is independently (a) Cl, (b) Br, (c) F, (d) CN, (e) C1-7alkyl, or (f) NO2; R2 is (a) H, (b) R5, (c) NR7R8, (d) SO2R10, or (e) OR9; A is C1-7alkyl; W is a five- (5) or six- (6) membered heterocyclic ring having one (1), two (2) or three (3) heteroatoms selected from the group consisting of O, S(O)k, and N wherein W is optionally substituted with one or more OH, oxo (&boxH;O), or C1-7-alkyl; B is (a) C1-7alkyl optionally substituted by OH or NR7R8, (b) O, or (c) NR11, R3 is (a) phenyl, optionally fused to a benzene or pyridine ring, and optionally substituted by R12, wherein optionally any two adjacent R12 substituents taken together constitute a group of the formula â€”O(CH2)Oâ€”, â€”(NH)C(&boxH;O)(CH2)jOâ€”, or (CH2)iâ€”, or (b) a five- (5) or six- (6) membered heteroaryl bonded via a carbon atom having one (1), two (2), or three (3) heteroatoms selected from the group consisting of O, S, and Nâ€”Z, wherein R3 is optionally fused to a benzene or pyridine ring, and optionally substituted with one or more R12, wherein Z is absence, H, or C1-4alkyl; R4 is (a) H, (b) halo, or (c) C1-4alkyl optionally substituted by halo; R5 is (a) (CH2)mOCH2CH2OR11, (b) het, wherein said het is bound via a carbon atom, (c) aryl, (d) C1-7alkyl which may be partially unsaturated and is optionally substituted by one or more R6 substituents, or (e) C3-8cycloalkyl which may be partially unsaturated and optionally substituted by one or more R6 or C1-7alkyl optionally substituted by R6; R6 is (a) OR9, (b) SR9, (c) NR7R8, (d) halo, (e) CONR7R8, (f) CO2R9, (g) het, (h) phenyl, optionally substituted by R12, (i) CN, (j) oxo, (k) SO2NR9R11, (l) SOmR10, or (m) P(&boxH;O)(OR11)(R11); R7 and R8 are independently (a) H, (b) aryl, (c) C1-7 alkyl which may be partially unsaturated and is optionally substituted by one or more NR11R11, OR11, SR11, SOmR10, CONR11R11, CO2R11, het, aryl, cyano, or halo, (d) C3-8cycloalkyl, (e) (C&boxH;O)R10, or (f) R7 and R8 together with the nitrogen to which they are attached form a het; R9 is (a) H, (b) aryl, (c) het, wherein the het is bound through a carbon atom, (d) C1-7alkyl which is optionally partially unsaturated and is optionally substituted by one or more aryl, het, OR11, SR11, NR11R11, halo, or C3-8cycloalkyl substituents and which C3-8cycloalkyl is optionally substituted by OR11, or (e) C3-8cycloalkyl which is optionally partially unsaturated and is optionally substituted by one or more halo, OR11, SR11, or NR11R11 substituents; R10 is (a) aryl, (b) het, (c) C1-7alkyl which is optionally partially unsaturated and is optionally substituted by one or more aryl, het, OR11, SR11, NR11R11, halo, or C3-8cycloalkyl substituents and which C3-8cycloalkyl is optionally substituted by OR11, or (d) C3-8 cycloalkyl which is optionally partially unsaturated and is optionally substituted by one or more halo, OR11, SR11, or NR11R11 substituents; R11 is (a) H, or (b) C1-7 alkyl; R12 is (a) halo, (b) OR14, (c) SR11, (d) NR7R8, (e) phenyl, optionally substituted by halo, C1-7alkyl, or C1-7alkoxy, (f) C1-7alkyl which is optionally partially unsaturated and optionally substituted by R13, (g) cyano, (h) nitro, (i) CONR7R8, (j) SO2NR7R8, (k) CO2R11, or (l) NHC(&boxH;O)R11; R13 is (a) phenyl, optionally substituted by halo, C1-7alkyl, or C1-7alkoxy, (b) OR11, (c) O(CH2CH2O)nR11, (d) NR7R8, or (e) halo; R14 is (a) H (b) alkyl optionally substituted by halo, (c) phenyl, optionally substituted by halo, C1-7alkyl, or C1-7alkoxy, or (d) â€”(CH2CH2O)nOR11; wherein any aryl is optionally substituted with one or more substituents selected from the group consisting of halo, OR11, NR11R11, cyano, CO2R11, or C1-7alkyl in which said C1-7alkyl is optionally substituted by one to three halo, OR11, or NR11R11; wherein any het is optionally substituted with one or more substituents selected from the group consisting of halo, OR11, NR11R11, cyano, CO2R11, oxo (&boxH;O), or C1-7alkyl in which said C1-7alkyl is optionally substituted by one to three halo, OR11, or NR11R11; i is 3 or 4; j is 0 or 1; k is 0, 1, or 2; each n is independently 1, 2, 3, 4 or 5; and each m is independently 1 or 2.