Patent ID: 6492105
Filing Date: 2002-12-10
Classification: C07K

Abstract:
A polypeptide which binds factor VIII or a fragment thereof retaining the procoagulant activity of factor VIII, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of:X1-X2-Cys-X3-X4-X5-X6-X7-Cys-X8-X9 (SEQ ID NO: 1), wherein X1 is Arg, Phe, His or Pro; X2 is Ser, Gly, Leu or His; X3 is Gly, Asn, Ile or Ser; X4 is Ser, Trp or Gly; X5 is Trp, Ile, Leu or Val; X6 is Phe, Trp or Ser; X7 is Pro or Phe; X8 is Ser, Leu, Pro or Phe; X9 is Ala, Phe, Leu or His; and Phe-Cys-X18-Val-X19-X20-Phe-X21-His-Cys-X22 (SEQ ID NO: 3), wherein X18 is His or Trp; X19 is His or Phe; X20 is Ala, Asn, His, or Pro; X21 is Ala, Asn, Asp, Gln, His, Leu, Ser, or Val; X22 is Ala, Asp, His, Leu, Phe, or Ser.