Patent ID: 6740670
Filing Date: 2004-05-25
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula I or a salt or prodrug thereof wherein X is O or S; A and B are OR2 or Yâ€”NR3R4, wherein when A is OR2, B is Yâ€”NR3R4 and vice versa, or when one of A or B is OR2, then the other can be CO2R7; Y is CH2 or C&boxH;O; Q is (CH2)mâ€”CH(R1)â€”(CH2)n; R is OR6 or NHR7; R1 is hydrogen, C1-C6 branched or straight chain alkyl optionally substituted with hydroxyl, C1-C3 alkylphenyl or phenyl; R2 is hydrogen, C1-C10 branched or straight chain alkyl, C3-C10 cycloalkyl, C2-C10 branched or straight chain alkenyl, C2-C10 branched or straight chain alkynyl, (CH2)mâ€”(CF2)nCF3, (CH2)nCH(R10)â€”(CH2)q-aryl or (CH2)p-aryl, where aryl is phenyl, pyridyl, thienyl or furyl; wherein phenyl is optionally substituted by one or more substituents sciected from F, Cl, Br, CF3, OCF3, OR6, C1-C6 branched or straight chain alkyl, COR, CN, SO2R9, or SONR7R8, and pyridyl, thienyl or furyl are optionally substituted by F, Cl, Br, CF3, OR6 or C1-C6 branched or straight chain alkyl; R3 and R4 are independently hydrogen, C1-C6 branchcd or straight chain alkyl, C(&boxH;O)R6, â€”CH(CH2OCOR8)-aryl or CH(R8)â€”(CH2)p-aryl where aryl is phenyl, pyridyl, thienyl or fury; wherein phenyl is optionally substituted by one or more substitucnts selectcd from F, Cl, Br, CF3, OCF3, OR6, C1-C6 branched or straight chain alkyl, COR, CN, SO2R7 or phenyl; or R3 and R4 when taken together may form a 4-7 membered ring optionally incorporating an additional heteroatom, selected from O, N or S, wherein the ring may be optionally substituted at any position with (CH2)p-aryl where aryl is phenyl optionally substituted by one or more substituents selected from F, Cl, Br, CF3, OCF3, C1-C6 branched or straight chain alkyl, COR, CN, SO2R8 or phenyl; R5 is hydrogen; R6 and R7 are independently hydrogen, C1-C10 branched or straight chain alkyl or (CH2)p-phenyl; R8 is hydrogen or C1-C3 alkyl; R9 is C1-C6 branched or straight chain alkyl or phenyl; R10 is hydrogen, C1-C10 branched or straight chain alkyl, (CH2)p-aryl where aryl is phenyl optionally substituted by one or more substituents selected from F, Cl, Br, CF3, OCF3, C1-C6 branched or straight chain alkyl, COR, CN, SO2R8; and m, n and p are integers wherein m is 0-3; n is 0-2; and p is 0-3.