Patent ID: 7687536
Filing Date: 2010-03-30
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of formula (I), or pharmaceutically acceptable salt thereof: wherein the bonds from the cycloalkyl ring to the 1-cinnamide and 2-amine groups in the compounds of formula (I) are relatively disposed in a trans relationship, and wherein, independently at each occurrence: n is selected from 1, 2, 3 and 4; X is selected from a direct bond, and —C(R Y is selected from a direct bond, O, S, and C R R R wherein the ring of formula (II) is formed from the nitrogen as shown as well as three to nine additional ring atoms independently selected from carbon, nitrogen, oxygen, and sulfur; where any two adjacent ring atoms may be joined together by single or double bonds, and where any one or more of the additional carbon ring atoms may be substituted with one or two substituents selected from hydrogen, hydroxy, C 1 -C 3 hydroxyalkyl, oxo, C 2 -C 4 acyl, C 1 -C 3 alkyl, C 2 -C 4 alkylcarboxy, C 1 -C 3 alkoxy, C 1 -C 20 alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two heteroatoms selected from oxygen and sulfur; and any two adjacent additional carbon ring atoms may be fused to a C 3 -C 8 carbocyclic ring, and any one or more of the additional nitrogen ring atoms may be substituted with substituents selected from hydrogen, C 1 -C 6 alkyl, C 2 -C 4 acyl, C 2 -C 4 hydroxyalkyl and C 3 -C 8 alkoxyalkyl; or R R R A is selected from C where R 7 , R 8 and R 9 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 -C 7 alkanoyloxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 7 alkoxycarbonyl, C 1 -C 6 thioalkyl, aryl and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 -C 6 alkyl; where R 10 and R 11 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 -C 7 alkanoyloxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 7 alkoxycarbonyl, C 1 -C 6 thioalkyl, and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 -C 6 alkyl; where R including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof; with a proviso that the compound of formula (I) is not a compound of the following formula: wherein, independently at each occurrence: n is selected from 1, 2, 3 and 4; X is a direct bond; R R R R A is selected from C where R 7 , R 8 and R 9 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 -C 7 alkanoyloxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 7 alkoxycarbonyl, C 1 -C 6 thioalkyl, aryl and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 -C 6 alkyl; including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof.