Patent ID: 8772446
Filing Date: 2014-07-08
Classification: A61K,C07D

Abstract:
1. A bifunctional chelating agent of the formula (I): wherein: -M- is Q Q Q Q A R is —C(O)-L, —(CHR 2 ) p COR 3 or —(CHR 2 ) p PO 2 R 4 R 5 ; Q R each R R X and Y are each independently hydrogen or may be taken with an adjacent X and Y to form an additional carbon—carbon bond; Z m is an integer from 0 to 10 inclusive; n is 0 or 1; p is 1 or 2; r is 0 or 1; w is 0 or 1; z is 1 or 2; L is a linker/spacer group covalently bonded to, and replacing one hydrogen atom of the carbon atom to which it is joined, said linker/spacer group being represented by the formula (II): wherein: provided that the chelating agent is not 6,6′,6″,6′″-((ethane-1,2-diylbis(azanetriyl))tetrakis(methylene))tetrapicolinic acid, 6,6′-((ethane-1,2-diylbis((phosphonomethyl)azanediyl))bis(methylene))dipicolinic acid, 6,6′-((ethane-1,2-diylbis((carboxymethyl)azanediyl))bis(methylene))dipicolinic acid or 6,6′-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))dipicolinic acid, and provided that the bifunctional chelating agent comprises at least one covalently attached moiety that allows for covalent attachment to the carrier comprising a biotargeting group, a lipophilic moiety or a biosensor.