Patent ID: 6465016
Filing Date: 2002-10-15
Classification: A61K,B82Y

Abstract:
A process of stabilizing solid cyclic oligopeptide cyclosporine microparticles, each microparticle consisting of a solid cyclic oligopeptide cyclosporine core, and preventing said microparticles from aggregating or flocculating by coating or adhering onto the surfaces of the solid cyclic oligopeptide cyclosporine core microparticles a mixture of a phospholipid together with at least one non-ionic, anionic or cationic second surface modifier, the process comprising the steps of:a) mixing particles of solid cyclic oligopeptide cyclosporine with a phospholipid and at least one non-ionic, anionic or cationic second surface modifier, and thereafter; b) applying energy to the mixture sufficient to produce volume-weighted mean particle size values of said solid cyclic oligopeptide cyclosporine core microparticles about 50% smaller than particles produced without the presence of the second surface modifier using the same energy input.