Patent ID: 6379649
Filing Date: 2002-04-30
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinY is selected from F, Cl, Br, I, OH, SH, NH2, CN, and COOH; Z is selected from N(R3)C(O)R4 and C(O)NR3R4; R1 and R2 are independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, (C6-C12)aryl, (C6-C12)aryloxy, (C6-C12)aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, heterocyclic, (C2-C6)alkanoyl and (C2-C7)acyl, each of which may be unsubstituted or substituted with from 1 to 3 substituents selected from the group consisting of halogen, OH, (C1-C4)alkoxy, SH, NH2, (C1-C4)alkylamino, di((C1-C4)alkyl)amino, carboxy, (C1-C4)alkoxycarbonyl, (C2-C4)alkanoyl, oxo, amido, CN, CNS, SCN, CNO, OCN, and NHOH; R3 and R4 are each independently hydrogen or a group selected from (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C6)cycloalkyl, (C6-C12)aryl, (C6-C12)aryl(C1-C4)alkyl, heteroaryl, heteroaryl(C1-C4)alkyl, heterocyclic, (C1-C4)alkoxycarbonyl and (C2-C5)acyl, each of which may be unsubstituted or substituted with from 1 to 3 substituents selected from the group consisting of halogen, OH, (C1-C4)alkoxy, SH, NH2, (C1-C4)alkylamino, di((C1-C4)alkyl)amino, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyl, oxo. amido, CN, CNS, SCN, CNO, OCN, and NHOH, or R3 and R4 together are (C2-C7)alkylidene which may be optionally substituted with from 1 to 3 substituents selected from the group consisting of halogen, OH, (C1-C4)alkoxy, SH, NH2, (C1-C4)alkylamino, di((C1-C4)alkyl)amino, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyl, oxo, amido, CN, CNS, SCN, CNO, OCN, and NHOH; m and n are independently 0, 1 or 2; and p is 1; wherein at each occurrence (i) alkenyl has the meaning of ethylenically mono- or di-unsaturated alkyl or ethylenically mono- or di-unsaturated cycloalkyl; (ii) cycloalkyl has the meaning of cyclic alkyl, or alkyl substituted cyclic alkyl; (iii) heteroaryl has the meaning of single, polynuclear, conjugated and fused residues of aromatic heterocyclic ring systems.