Patent ID: 6190699
Filing Date: 2001-02-20
Classification: A61K

Abstract:
A pharmaceutical composition comprising a matrix material selected from the group consisting of chitosan, algin, saturated polyglycolysed glyceride, glycerol palrnitostearate, saturated C.sub.12 to C.sub.22 fatty acid esters of polyalcohol, glyceryl and polyethylene glycol behenate, polyethylene oxide, and ammonium glycyrrhizinate in the form of microparticles containing a protein or peptide selected from the group consisting of insulin, glucagons, calcitonin, atrial naturetic peptide, muramyl dipeptides, secretin, cholecystokinin, thyrotrophin releasing hormone, thymopentin, adrenocorticotripic hormone, growth hormone releasing factor, enkephalin, oxytocin, vasopressin and luteinizing hormone releasing hormone said composition being produced by infusing into or onto said matrix material by:(a) providing in a pressure vessel an intimate mixture of said protein or peptide with the particles of the matrix material;(b) contacting a compressed solvent, which is normally gaseous at ambient temperature and pressure, with said matrix material and said protein and peptide in the pressure vessel under conditions effective to permit sorption of at least a portion of said protein or peptide and said compressed solvent into said matrix material;(c) separating said solvent from said matrix material, thereby entrapping the infused protein or peptide.