Patent ID: 6730694
Filing Date: 2004-05-04
Classification: C07D

Abstract:
A substituted pyrrolo compound represented by the formula (I), or a pharmaceutically acceptable salt, solvate, or prodrug derivative thereof; wherein;A is S, SO, SO2, O, or NR, and R is a non-interfering substituent; R1 is selected from groups (a), (b), and (c) wherein; (a) is C7-C20 alkyl, C7-C20 haloalkyl, C7-C20 alkenyl, C7-C20 alkynyl, carbocyclic radical, or heterocyclic radical, or (b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or (c) is the group â€”(L1)â€”R11; where, â€”(L1)â€” is a divalent linking group of 1 to 8 atoms and where R11 is a group selected from (a) or (b); R2 is hydrogen, or a group containing 1 to 4 non-hydrogen atom plus any required hydrogen atoms; R3 is â€”(L3)â€” Z, where â€”(L3)â€” is a divalent linker group selected from a bond or a divatent group selected from; â€ƒand Z is selected from a group represented by the formulae, â€ƒwherein, X is oxygen or sulfur; and Ra is selected from hydrogen, C1-C8 alkyl, aryl, C1-C8 alkaryl, C1-C8 alkoxy, aralkyl and â€”CN; R4 is the group hydrogen; or the group WR4e wherein W is oxygen, Sulfur or NH, and R4e is an alkyl, aryl or an alkylaryl group; or the group â€”(La)â€”(acidic group); wherein â€”(La)â€”, is an acid linker having an acid linker length of 1 to 8; or the group â€”(Lh)â€”(N-hydroxyfunctional amide group); wherein â€”(Lh)â€”, is an N-hydroxyfunctional amide linker having an N-hydroxyfunctional amide linker length of 1 to 8; or the group â€”(Lc)â€”(acylamino acid group); wherein â€”(Lc)â€”, is an acylamino acid linker having an acylamino acid linker length of 1 to 8; R5 is selected from hydrogen, a non-interfering substituent, or the group, â€”(La)â€”(acidic group); wherein â€”(La)â€”, is an acid linker having an acid linker length of 1 to 8.