Patent ID: 6897295
Filing Date: 2005-05-24
Classification: C07K

Abstract:
1. A purified antibody or fragment thereof which specifically binds to at least one polypeptide of at least 10 amino acids selected from the group consisting of; a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 2, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 4, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 4, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 6, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 6, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 8, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 8, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 10, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 10, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 12, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 12, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 14, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 14, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 16, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 16, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 18, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 18, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 20, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 20, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 22, wherein said antibody or fragment thereof binds an antizenic determinant located in SEQ ID NO: 22, a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 24, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 24, the polypeptide according to any one of the above mentioned polypeptides, wherein the polypeptide is capable of binding to Fas antigen, the polypeptide according to any one of the above mentioned polypeptides, wherein the polypeptide has activity inducing apoptosis of a Fas antigen-expressing cell, the polypeptide according to any one of the above mentioned polypeptides, wherein the polypeptide is obtained by genetic engineering techniques, a fragment of a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 8, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 8, a fragment of a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 16, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 16, a fragment of a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO: 24, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NO: 24, a fusion polypeptide comprising at least two polypeptides, wherein said at least two polypeptides are selected from polypeptides or fragments thereof of the amino acid sequences as set forth in SEQ ID NOs: 8, 16, or 24, wherein said antibody or fragment thereof binds an antigenic determinant located in SEQ ID NOs: 8, 16, or 24, and the polypeptide according to any one of the above mentioned polypeptides, wherein the polypeptide binds to Fas antigen.