Patent ID: 7432394
Filing Date: 2008-10-07
Classification: C07B,C07C

Abstract:
1. A method for producing a compound of the formula (I): in an enantiomerically enriched form wherein R X is halide; said method comprising: (a) contacting a mixture of a first enantiomer and a second enantiomer of a compound of formula (I) with at most about 0.5 molar equivalents of an enantiomerically enriched 1-(2-naphthyl)ethylamine under conditions sufficient to form a solid naphthylalkylammonium salt of said first enantiomer and decrease the ratio of the amount of free first enantiomer to the amount of free second enantiomer in the mixture; (b) separating the naphthylalkylammonium salt of the first enantiomer from the mixture; and (c) separating the naphthylalkylamine from the first enantiomer in the naphthylalkylammonium salt to produce compound of formula (I) in an optical purity of at least about 97.5% in at least about 75% yield.