Patent ID: 7586020
Filing Date: 2009-09-08
Classification: A61K

Abstract:
1. A method for screening compounds that affect mouse agouti coat color prevalence in progeny heterozygous for agouti alleles, comprising: administering a treatment consisting of one or more candidate compounds to a homozygous a/a female; crossing the a/a female with an heterozygous A determining the prevalence of agouti coat color phenotypes in A comparing the prevalence of agouti coat color phenotypes in A wherein an increased prevalence of agouti coat color is indicative of a compound effective in increasing the agouti coat color with known associated decreases in the prevalence of associated cancers, obesity and diabetes, and increased longevity, in such progeny, and wherein a decreased prevalence of agouti coat color is indicative of a compound effective in decreasing the agouti coat color with known associated increases in the prevalence of associated cancers, obesity and diabetes, and decreased longevity, in such progeny.