Patent ID: 7627436
Filing Date: 2009-12-01
Classification: C12Q,G16B

Abstract:
1. A method of selecting a SNP marker set to discriminate presence or absence of a disease in a subject, comprising: amplifying and determining sequences of a plurality of SNPs in DNA samples from a case population having a disease and from a control population and determining a plurality of SNP markers associated with the disease; selecting a maximum number of SNP markers from the plurality of SNP markers associated with the disease for a SNP marker set to discriminate presence or absence of the disease in a subject by; performing discrimination analysis on combinations of the SNP markers consisting of up to j SNP markers; and analyzing each combination by receiver operating characteristics (ROC) curve analysis to determine an area under the curve; selecting a SNP marker set having the highest association with the disease from the analyzed combinations, wherein the selected SNP marker set is the analyzed combination having the largest area under the curve, the highest sensitivity, the lowest specificity, or the smallest number of SNP markers; and, outputting the selected SNP marker set to a user.