Patent ID: 8426360
Filing Date: 2013-04-23
Classification: C07D

Abstract:
1. A compound of Formula I or Formula II: or a pharmaceutically acceptable salt thereof, wherein R alternatively, R 1 and R 2 taken together with the carbon atom to which they are attached form a cyclic moiety selected from: substituted or unsubstituted cycloalkyl, cycloalkenyl, or heterocyclic; substituted or unsubstituted cycloalkyl, cycloalkenyl, or heterocyclic each fused with one or more group selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, —C 3 -C 12 cycloalkyl, substituted —C 3 -C 12 cycloalkyl, —C 3 -C 12 cycloalkenyl, and substituted —C 3 -C 12 cycloalkenyl; G is -E-R 3 , where E is absent, or E is selected from the group consisting of O, CO, (CO)O, (CO)NH, NH, NH(CO), NH(CO)NH, NH(SO 2 )NH and NHSO 2 ; where R 3 is as previously defined; L is selected from the group consisting of CH 2 , O, NR 5 , S, SO, and SO 2 ; A is selected from the group consisting of R 5 , (CO)R 5 , (CO)OR 5 , (CO)NHR 5 , NHR 5 , NH(CO)R 5 , NH(CO)OR 5 ; SO 2 R 5 , (SO 2 )OR 5 and SO 2 NHR 5 ; R 5 is selected from the group consisting of: a) hydrogen; b) aryl; c) substituted aryl; d) heteroaryl; e) substituted heteroaryl; f) heterocyclic; g) substituted heterocyclic; h) —C i) substituted —C j) —C k) substituted —C l) —C m) substituted —C U is selected from the group consisting of: (a) oxygen; (b) sulfur; (c) NR (d) —(CH T is selected from the group consisting of R 5 , OR 5 , NR 51 R 52 , NHSO 2 R 5 , COR 5 , NHCOR 5 , NH(SO 2 )R 5 , and NHSO 2 NHR 5 ; where R 5 is as previously defined; R 51 and R 52 are each independently selected from the group consisting of: (a) hydrogen; (b) aryl; (c) substituted aryl; (d) heteroaryl; (e) substituted heteroaryl; (f) heterocyclic or substituted heterocyclic; (g) —C (h) substituted —C (i) —C (j) substituted —C (k) —C (l) substituted —C (m) —NH(CO)OR (n) —CHR (o) —NHCHR or R 51 and R 52 are taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted heterocyclic; Z is selected from the group consisting of: (a) hydrogen; (b) aryl; (c) substituted aryl; (d) heteroaryl; (e) substituted heteroaryl; (f) heterocyclic; (g) substituted heterocyclic; (h) —C (i) substituted —C (j) —C (k) substituted —C j=0, 1, 2 or 3; k=0, 1, 2 or 3; m=0, 1, 2 or 3; n=0, 1, 2 or 3; and h=1, 2 or 3.