Patent ID: 7041834
Filing Date: 2006-05-09
Classification: A61P,C07D

Abstract:
1. A process, which comprises contacting a carbazolone of formula (2), formaldehyde or a formaldehyde precursor, and an amine of formula (3) or a salt thereof wherein R 1 and R 2 each independently represent a C 1 to C 4 alkyl group or together with the nitrogen atom they form a 5- or 6-membered ring, in a non-aqueous polar solvent and in the presence of a non-polymeric water binding agent to form a reaction mixture; reacting said carbazolone of formula (2) in said reaction mixture to form an intermediate-carbazolone reaction mixture; and reacting in said intermediate-carbazolone reaction mixture an imidazole of formula (5) or a salt thereof to form a compound of formula (1)