Patent ID: 7723367
Filing Date: 2010-05-25
Classification: A61P,C07D

Abstract:
1. A method for treating chronic inflammatory pain or neuropathic pain comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a compound having Formula (I) or Formula (II), or a therapeutically acceptable salt thereof, in which R R R R m is 0, 1, 2, or 3; X and Y are independently selected from the group consisting of —H, —C X and Y together with the carbon atom to which they are attached form a ring selected from the group consisting of cyclopropane, cyclobutane, cyclopentane, cyclohexane, tetrahydrofuran, tetrahydrothiophene, pyrrolidine, dioxolane, tetrahydropyran, piperidine, morpholine, thiomorpholine, and piperazine, each or which is unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NH Z is —H, —C Z and X together with the atoms to which they are attached form a ring selected from the group consisting of pyrrolidine, piperidine, morpholine, thiomorpholine, and piperazine; R R R R R R R R R R provided that when R 1 is phenyl fused with a pyrrole, thiophene, furan, pyrazole, isoxazole, or isothiazole ring, the pyrrole, thiophene, furan, pyrazole, isoxazole, or isothiazole ring is not substituted with —C 1 -alkyl, —C 2 -alkyl, —C 3 -alkyl, —C 4 -alkyl, —C 5 -alkyl, —C 6 -alkyl, pyrrolidinyl, piperidyl, tetrahydropyridyl, pyrrolinyl, —C 1 -alkyl substituted with pyrrolidinyl or piperidyl, —C 2 -alkyl substituted with —N(R 1d ) 2 , —NH 2 or —NHR 1d , —C 3 -alkyl substituted with —N(R 1d ) 2 , —NH 2 , or —NHR 1d , —C 4 -alkyl substituted with —N(R 1d ) 2 , —NH 2 , or —NHR 1d , —C 5 -alkyl substituted with —N(R 1d ) 2 , —NH 2 , or —NHR 1d , or —C 6 -alkyl substituted with —N(R 1d ) 2 , —NH 2 , or —NHR 1d ; and provided that when m is 0 and R 2 is phenyl, then R 1 is not unfused phenyl; A is N or CR B is N or CR B is N or CR provided that only one of A, B and E is N; R R R R R R R R R R v is one, two, or three, and when v is two or three, R R R R R R R R R R R R R R R R R R R R R with the proviso that the following compounds are excluded: N-benzyl-1-(4-methoxyphenyl)-1H-tetraazol-5-amine; N,1-bis(4-methylphenyl)-1H-tetraazol-5-amine; N,1-bis(4-methoxyphenyl)-1H-tetraazol-5-amine; and N,1-bis(2,4-dimethylphenyl)-1H-tetraazol-5-amine.