Patent ID: 8410251
Filing Date: 2013-04-02
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody which is reactive to a calcified globule (NLO) derived from renal or urinary calculi and has the activity of binding to an atherosclerotic plaque, which is the antibody of any one of (e), (j), or (o): (a) an antibody comprising a heavy chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 1, CDR2 having the amino acid sequence of SEQ ID NO: 2, and CDR3 having the amino acid sequence of SEQ ID NO: 3; (b) an antibody comprising a heavy chain that comprises a heavy-chain variable region having the amino acid sequence of SEQ ID NO: 4; (c) an antibody comprising a light chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 6, CDR2 having the amino acid sequence of SEQ ID NO: 7, and CDR3 having the amino acid sequence of SEQ ID NO: 8; (d) an antibody comprising a light chain that comprises a light-chain variable region having the amino acid sequence of SEQ ID NO: 9; (e) an antibody that comprises a pair of the heavy chain of (a) or (b) and the light chain of (c) or (d); (f) an antibody comprising a heavy chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 11, CDR2 having the amino acid sequence of SEQ ID NO: 12, and CDR3 having the amino acid sequence of SEQ ID NO: 13; (g) an antibody comprising a heavy chain that comprises a heavy-chain variable region having the amino acid sequence of SEQ ID NO: 14; (h) an antibody comprising a light chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 16, CDR2 having the amino acid sequence of SEQ ID NO: 17, and CDR3 having the amino acid sequence of SEQ ID NO: 18; (i) an antibody comprising a light chain that comprises a light-chain variable region having the amino acid sequence of SEQ ID NO: 19; (j) an antibody that comprises a pair of the heavy chain of (f) or (g) and the light chain of (h) or (i); (k) an antibody comprising a heavy chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 21, CDR2 having the amino acid sequence of SEQ ID NO: 22, and CDR3 having the amino acid sequence of SEQ ID NO: 23; (l) an antibody comprising a heavy chain that comprises a heavy-chain variable region having the amino acid sequence of SEQ ID NO: 24; (m) an antibody comprising a light chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 26, CDR2 having the amino acid sequence of SEQ ID NO: 27, and CDR3 having the amino acid sequence of SEQ ID NO: 28; (n) an antibody comprising a light chain that comprises a light-chain variable region having the amino acid sequence of SEQ ID NO: 29; (o) an antibody that comprises a pair of the heavy chain of (k) or (l) and the light chain of (m) or (n).