Patent ID: 6239132
Filing Date: 2001-05-29
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR32##or a pharmaceutically acceptable salt thereof,wherein A is ##STR33##R.sup.5 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, halogen, NH.sub.2, OH or C.sub.1-4 alkoxy;R.sup.4 is hydrogen, Cl, F, C.sub.1-4 alkyl or NH.sub.2 ;Y is hydrogen, Cl, or F;R.sup.1 and R.sup.2 are independentlyhydrogen,phenyl, unsubstituted or substituted with one or more of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R.sup.8, where R.sup.8 is C.sub.1-4 alkyl, or SO.sub.2 NH.sub.2,CHR.sup.6 R.sup.7wherein R.sup.6 and R.sup.7 are independentlyhydrogen,unsubstituted C.sub.1-4 alkyl,C.sub.1-4 alkyl substituted with OH, COOH, NH.sub.2, aryl, CF.sub.3,C.sub.3-7 cycloalkyl,CF.sub.3CH.sub.2 C.sub.3-7 cycloalkyl, unsubstituted or substituted with aryl,C.sub.7-12 bicyclic alkyl, orC.sub.10-16 tricyclic alkyl; andR.sup.9 is C.sub.1-4 alkyl or SO.sub.2 NH.sub.2.