Patent ID: 6080724
Filing Date: 2000-06-27
Classification: A61K,C07K,C12N

Abstract:
A process of transporting into a living cell a molecule comprising,linking said molecule to a peptidic vector comprising of a peptide having an amino acid sequence represented by formula (I)NH.sub.2 -X.sub.1 -X.sub.2 -X.sub.3 -X.sub.4 -X.sub.5 -X.sub.6 -X.sub.7 -X.sub.8 -X.sub.9 -X.sub.10 -X.sub.11 -X.sub.12 -X.sub.13 -X.sub.14 -X.sub.15 -X.sub.16 -COOHor formula (Ia)NH.sub.2 -X.sub.16 -X15-X.sub.14 -X.sub.13 -X.sub.12 -X.sub.11 -X.sub.10 -X.sub.9 -X.sub.8 -X.sub.7 -X.sub.6 -X.sub.5 -X.sub.4 -X.sub.3 -X.sub.2 -X.sub.1 -COOHwherein(a) X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, X.sub.7, X.sub.8, X.sub.9, X.sub.10, X.sub.11, X.sub.12, X.sub.13, X.sub.14, X.sub.15, and X.sub.16 each represents an .alpha.-amino acid, from 6 to 10 of which are hydrophobic amino acids;(b) X.sub.6 represents tryptophan;(c) X.sub.3 and X.sub.5 are not both valine in the same sequence; and(d) formula (I) and formula (Ia) do not represent a peptide having a sequence of SEQ ID NO:1; andcontacting said living cell with said peptidic vector with said molecule linked thereto, whereby said molecule is carried across membranes of the living cell.