Patent ID: 6642264
Filing Date: 2003-11-04
Classification: A61K,A61P,C07D

Abstract:
A thiazolobenzoimidazole derivative represented by the following general formula (I) or a salt thereof wherein each of the symbols is defined as followsR1: (1) â€”A1â€”COâ€”N(R6)â€”R7, or (3) â€”A1â€”COâ€”A3â€”N(R6)â€”R7, A1: a bond, R6 and R7: the same or different from each other and each represents hydrogen, â€”N(R15)â€”R16, a lower alkyl which may be substituted, a cycloalkyl which may be substituted or a hetero ring which may be substituted and may have bridge(s), with the proviso that R6 and R7, together with the adjacent nitrogen atom, may form a hetero ring which may have a substituent and other hetero atom(s), and when R1 is â€”A1â€”COâ€”N(R6)â€”R7, R2 is methyl, A1 is a bond, and one of R6 and R7 is a hydrogen, the other is not n-propyl substituted by nicotinamide, R15 and R16: the same or different from each other and each represents hydrogen, â€”CO-lower alkyl, â€”CO-halo-lower alkyl or â€”COOR14, A3: a lower alkylene group which may be substituted by hydroxyl group(s), R2: hydrogen, a lower alkyl, a halo-lower alkyl, a hydroxy-lower alkyl, a lower alkyl-O-lower alkyl, an amino-lower alkyl or a (mono-or di-lower alkyl-amino)-lower alkyl group, R3, R4 and R5: the same or different from one another and each represents hydrogen, a halo, a lower alkyl, a halo-lower alkyl, an N3-lower alkyl, a hydroxy-lower alkyl, hydroxy, a lower alkyl-Oâ€”, cyano, â€”COOR14, acyl, a formyl-lower alkyl, an acyl-Oâ€”, an acyl-O-lower alkyl, nitro, â€”A4â€”N(R12)â€”(R13), â€”SO3H or â€”A5â€”Oâ€”A4â€”N(R12)â€”(R13) group, R12 and R13: the same or different from each other and each represents hydrogen, a â€”COâ€”lower alkyl-N(R15)â€”R16, a â€”CO-halo-lower alkyl group, a lower alkyl which may be substituted or a hetero ring group which may be substituted, with the proviso that R12 and R13, together with the adjacent nitrogen atom, may form a hetero ring which may have a substituent and other hetero atom(s), and when R12 and R13 are hydrogen at the same time, A4 is other than a bond, R14: hydrogen or a lower alkyl group, A4: a bond or a lower alkylene group which may be substituted by hydroxyl group(s), and A5: a bond or a lower alkylene group.