Patent ID: 7495006
Filing Date: 2009-02-24
Classification: A61P,C07H

Abstract:
1. A cyclobutyl nucleoside of the formula (I)-(IV): or a pharmaceutically acceptable salt, ester, salt of an ester, prodrug, salt of a prodrug, enantiomer, diastereomer, or tautomer thereof, wherein; Base is a purine or pyrimidine base; Z is independently phosphate selected from the group consisting of monophosphate, diphosphate, triphosphate and a stabilized phosphate prodrug, P(O)Z′Z″, CH Z′ and Z″ each independently is OH, OAlkyl, OAryl, alkyl, aryl, SH, SAlkyl, SAryl, NH A is O, S, or CH A can be a covalent bond when Z is P(O)Z′Z″ or CH R R R X is CH Y is independently H, methyl, halogenated methyl, CF