Patent ID: 7402392
Filing Date: 2008-07-22
Classification: A61K

Abstract:
1. A method for identifying a peptide that binds a radiation induced target in an irradiated tumor in a subject, the method comprising: (a) exposing a tumor in a subject to ionizing radiation; (b) administering to the subject a library of phage-displayed peptides wherein: (i)the phage-displayed peptides are 5-100 amino acids in length; and (ii) the administering step is performed about 4 hours to about 24 hours following he exposing step; (c) procuring from the subject the irradiated tumor or a fraction thereof; (d) isolating at least one phage from the procured irradiated tumor or from the a fraction thereof, wherein the at least one phage is bound to a radiation induced target in the procured irradiated tumor or the fraction thereof via a peptide displayed on its surface; and (e) identifying the peptide displayed on the surface of the phage that binds to the radiation-induced target in the irradiated tumor in the subject.