Patent ID: 7378529
Filing Date: 2008-05-27
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A compound of formula IIIf: wherein R R R R R X is selected from the group consisting of hydroxyl, alkoxy, substituted alkoxy, alkenyloxy, substituted alkenyloxy, cycloalkoxy, substituted cycloalkoxy, cycloalkenyloxy, substituted cycloalkenyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy and —NR″R″ where each R″ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; b is 1 or 2; or enantiomers, diastereomers, or pharmaceutically acceptable salts thereof; and further wherein the compound of formula IIIf has a binding affinity to VLA-4 as expressed by an IC