Patent ID: 6458795
Filing Date: 2002-10-01
Classification: A61K

Abstract:
A method for treating irritable bowel syndrome in a subject in need of such treatment, comprising administering to said subject an amount of a polyamine effective to treat irritable bowel syndrome in said subject, said polyamine being selected from the group consisting of polyamine having the formula:Râ€”NHâ€”(CH2)aâ€”NHâ€”(CH2)bHâ€”(CH2)câ€”NH2,â€ƒâ€ƒ1) CF3â€”C6H5â€”(CH2)aâ€”NHâ€”(CH2)bâ€”NHâ€”(CH2)câ€”NHâ€”(CH2)dâ€”NHâ€”(CH2)eâ€”C6H5â€”CF3,â€ƒâ€ƒ2) Râ€”NHâ€”(CH2)aâ€”NHâ€”C6H6â€”NHâ€”(CH2)bâ€”NHâ€”Râ€ƒâ€ƒ3) andPIPâ€”(CH2)aâ€”NHâ€”(CH2)bâ€”NHâ€”(CH2)câ€”PIP,â€ƒâ€ƒ4) wherein:R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of said alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10.