Patent ID: 6465189
Filing Date: 2002-10-15
Classification: A61K,C07K,C12N,C12P

Abstract:
A blended nucleic acid ligand of a target compound, wherein the nucleic acid ligand is identified from a blended candidate mixture comprised of blended nucleic acids each having at least one nucleic acid region and at least one functional unit, according to the method comprising:a) contacting the blended candidate mixture with the target, wherein blended nucleic acids having an increased affinity to the target relative to the blended candidate mixture may be partitioned from the remainder of the blended candidate mixture; b) partitioning the increased affinity blended nucleic acids from the remainder of the blended candidate mixture; and c) amplifying the increased affinity blended nucleic acids to yield a ligand-enriched mixture of blended nucleic acids, whereby a blended nucleic acid ligand of the target compound may be identified.