Patent ID: 8809274
Filing Date: 2014-08-19
Classification: A61K,A61L,A61P

Abstract:
1. A method for preparing a collagen-based adhesive hemostatic agent, comprising: (a) removing immunogenic telo-peptides from porcine collagen through enzyme treatment to afford an atelocollagen; (b) reacting an aqueous solution of the atelocollagen with an ethanol solution to afford an esterified atelocollagen; (c) adding 3,4-dihydroxy-phenyl alanine to an aqueous solution containing calcium chloride; (d) mixing an aqueous solution containing the esterified atelocollagen with the aqueous solution obtained by the step (c); and wherein the 3,4-dihydroxy-phenyl alanine is oxidized into catecholamine which is associated with a lysine moiety of the esterified atelocollagen, so as to provide adhesiveness to the hemostatic agent.