Patent ID: 8487125
Filing Date: 2013-07-16
Classification: C07C

Abstract:
1. A method of preparing a compound of formula (I): wherein each of R 1 and R 2 , independently, is C 1-8 alkylene, C 2-8 alkenylene, or deleted; each of A 1 and A 2 , independently, is aryl or heteroaryl, optionally substituted with halogen, —CN, —NO 2 , —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 OR 4 , —C(O)R 3 , —S(O)R 3 , —S(O)OR 3 , —NR 4 R 5 , —C(O)NR 4 R 5 , —OC(O)R 4 , —NR 4 C(O)R 5 ; and each of Q and Y, independently, is O, S, or NR 6 ; R 3 being C 1-4 alkyl and each of R 4 , R 5 , and R 6 , independently, being H or C 1-4 alkyl; the method comprising: reacting, in a solvent, a salt of a compound of formula (II): with an organic halide having the formula X—R 2 -A 2 , wherein X is a halogen, in the presence of an iodide catalyst having the formula M-I, wherein M is an alkali metal, to produce the compound of formula (I); and isolating the compound of formula (I) from the solvent.