Patent ID: 6133276
Filing Date: 2000-10-17
Classification: A61P,C07D

Abstract:
A compound having the structure: ##STR46## including keto tautomers, stereoisomers and pharmaceutically acceptable acid addition salts thereof, whereinW is selected from S and O;R.sub.1 ' and R.sub.2 ' are the same or different and independently selected from C.sub.1-8 alkyl, C.sub.1-8 alkyloxyC.sub.1-8 alkyl, aryl, substituted aryl, arylC.sub.1-8 alkyl, substituted arylC.sub.1-8 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-8 alkyl, C.sub.1-12 heteroaryl, substituted C.sub.1-12 heteroaryl, C.sub.1-12 heteroarylC.sub.1-8 alkyl, substituted C.sub.1-12 heteroarylC.sub.1-8 alkyl, C.sub.1-12 heteroarylC.sub.2-8 alkenyl and substituted C.sub.1-12 heteroarylC.sub.2-8 alkenyl; andR.sub.3 ' is selected from C.sub.1-12 heteroaryl, substituted C.sub.1-12 heteroaryl, C.sub.1-12 heteroarylC.sub.1-8 alkyl, substituted C.sub.1-12 heteroarylC.sub.1-8 alkyl, C.sub.1-12 heteroarylC.sub.2-8 alkenyl, substituted C.sub.1-12 heteroarylC.sub.2-8 alkenyl and the following structures: ##STR47## wherein n is 0, 1 or 2; andR.sub.4 ' is selected from aryl and substituted aryl with one or more substituents independently selected from halo and C.sub.1-8 alkyloxy.