Patent ID: 6821723
Filing Date: 2004-11-23
Classification: A61K,A61P,C07K,C12N

Abstract:
A polypeptide comprising a sequence of formula I:[Nâˆ’S1]nâˆ’Câˆ’[S2âˆ’N]m whereinN represents the sequence of amino acids 30 to 77 of gp41, C represents the sequence of amino acids 117 to 154 of gp41, S1 and S2 are, independently of one another, either absent or represent an amino acid sequence such that the sequence of formula I adopts an alpha-helical conformation as determined by the SOPMA program under the following conditions:a) number of conformational states=4 b) similarity limit=8, and c) window width=70 andn=0 or 1; m=0 or 1 and m+n=1 or 2.