Patent ID: 6194448
Filing Date: 2001-02-27
Classification: A61P,C07D

Abstract:
A compound of the structure ##STR64##whereinA is selected from the group consisting of --O--, --S--, and --NR.sup.6 --;E is selected from the group consisting of --CH.sub.2 --, --O--, --S--, and --NR.sup.7 --;each J is independently selected from the group consisting of --O--, --S-- and --NR.sup.8 --;T is selected from the group consisting of --C(O)-- and --(CH.sub.2).sub.b -- wherein b is an integer of from 0 to 3;s and t are each independently integers of zero to three;L is selected from the group consisting of --O--, --NR.sup.9 --, --S--, and --(CH.sub.2).sub.n -- wherein n is an integer of 0 or 1;M is selected from the group consisting of --C(R.sup.10)(R.sup.11)-- and --(CH.sub.2).sub.u -- wherein u is an integer of from 0 to 3;X is selected from the group consisting of --CO.sub.2 B, --PO.sub.3 H.sub.2, --SO.sub.3 H, --OPO.sub.3 H.sub.2, --C(O)NHC(O)R.sup.12, --C(O)NHSO.sub.2 R.sup.13, oxazolyl, tetrazolyl and hydrogen;B, R.sup.1, R.sup.2, R.sup.3, 0R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, thioalkoxy, aliphatic acyl, --CF.sub.3, nitro, amino, cyano, --N(C.sub.1 -C.sub.3 alkyl)--C(O)(C.sub.1 -C.sub.3 alkyl), --C.sub.1 -C.sub.3 alkylamino, alkenylamino, alkynylamino, di(C.sub.1 -C.sub.3 alkyl)amino, --C(O)O--(C.sub.1 -C.sub.3 alkyl), --C(O)NH--(C.sub.1 -C.sub.3 alkyl), --CH.dbd.NOH, --PO.sub.3 H.sub.2, --OPO.sub.3 H.sub.2, --C(O)N(C.sub.1 -C.sub.3 alkyl).sub.2, haloalkyl, alkoxylcarbonyl, alkoxyalkoxy, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, aroyl, aryloxy, arylamino, biaryl, thioaryl, heterocyclyl, heterocycloyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, sulfonyl, sulfonamido, carbamate, aryloxyalkyl, carboxyl and --C(O)NH(benzyl);wherein B, X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are unsubstituted or substituted with at least one electron donating or electron withdrawing group;and wherein R.sup.3 and R.sup.4 taken together may form a first ring;R.sup.5 and R.sup.9 taken together may form a second ring;R.sup.10 and R.sup.11 taken together may form a third ring;R.sup.1 and R.sup.2 taken together may form a fourth ring;and pharmaceutically acceptable salts thereof.