Patent ID: 9116153
Filing Date: 2015-08-25
Classification: A61P,C07K,G01N

Abstract:
1. A method for predicting the risk of a subject for contracting diabetes mellitus and/or metabolic syndrome or for identifying a subject having an enhanced risk for contracting diabetes mellitus and/or metabolic syndrome or for diagnosing metabolic syndrome in a subject wherein said subject is non-diabetic, comprising: (a) detecting and quantitating the level of a marker consisting of arginine vasopressin pro-hormone or fragments thereof in a sample from said patient, (b) predicting the risk of the subject for contracting diabetes mellitus and/or metabolic syndrome or inferring from it a risk for contracting diabetes mellitus and/or metabolic syndrome for said subject or for diagnosing metabolic syndrome in said subject by comparing the level of arginine vasopressin pro-hormone, copeptin or neurophysin II in the patient to the level of arginine vasopressin pro-hormone, copeptin or neurophysin II in an ensemble of pre-determined samples in a population of comparable apparently healthy subjects who later contracted diabetes mellitus or metabolic syndrome or did not contract said conditions, wherein said prediction or inference is based on a statistically significant correlation of the level of the marker in the patient sample with the levels of the marker in the pre-determined samples.