Patent ID: 8580736
Filing Date: 2013-11-12
Classification: A61K,A61P,C07K,C12N,C12Q,G01N,Y10T

Abstract:
1. A method for the promotion of angiogenesis and/or vasculogenesis in a subject in need thereof, comprising administering a pharmaceutical composition comprising an angiogenesis and/or vasculogenesis-promoting amount of an Rspondin polypeptide, wherein the Rspondin polypeptide is an Rspondin 2 or Rspondin 3 polypeptide, wherein the Rspondin 2 polypeptide comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence having at least 90% identity to SEQ ID NO: 19 and capable of promoting angiogenesis and/or vasculogenesis, and wherein the Rspondin 3 polypeptide comprises the amino acid sequence of SEQ ID NO: 21 or an amino acid sequence having at least 90% identity to SEQ ID NO: 21 and capable of promoting angiogenesis and/or vasculogenesis.