Patent ID: 6835714
Filing Date: 2004-12-28
Classification: A61K,A61P,C07D,C07K

Abstract:
A heterocyclic compound of the formula (I-a): wherein * means that the carbon atom marked with * is an asymmetric carbon atom,A and B are the same or different and each is a lower alkylene group being optionally substituted by an oxo group, D is a heteromonocyclic or heterobicyclic group of the following formula: â€ƒwherein D1 is a methylene group or an ethylene group, and these groups may optionally be substituted by an oxo group, Ring G is a 5- to 14-membered, saturated or unsaturated, heteromonocyclic or heterobicyclic group optionally having other heteroatoms selected from a nitrogen atom, an oxygen atom and/or a sulfur atom, and said heteromonocyclic or heterobicyclic group being optionally substituted by a substituent T1 in which T1 is the same or different 1 to 3 groups selected from (i) an oxo group, (ii) a substituted or unsubstituted lower alkyl group, (iii) a substituted or unsubstituted amino group, (iv) a substituted or unsubstituted carbamoyl group, (v) a carboxyl group or a lower alkoxycarbonyl group, (vi) a phenyl group being optionally substituted by a halogen atom, a lower alkoxy group or a, lower alkyl group, and (vii) a substituted or unsubstituted lower alkylcarbonyl group, R1 and R2 are the same or different and each is a lower alkyl group, R3 and R4 are different from each other, and each is a hydrogen atom or a hydroxy group, or both combine together to form an oxo group, R5 is a group of the formula: â€ƒwherein X1 and X2 are a halogen atom, Y1 is a hydrogen atom, a halogen atom, a lower alkoxycarbonyl group, a lower alkylaminocarbonyl group, an aralkylaminocarbonyl group, an aralkyloxycarbonyl group, a lower alkylcarbonyl group, or an aralkylcarbonyl group, or a group of the following formula: â€ƒwherein U is an oxygen atom or a sulfur atom, Q is a vinylene group or an orthophenylene group being optionally substituted by T2, T2 is 1 to 3 groups selected from a halogen-substituted or unsubstituted lower alkyl group, a lower alkoxy group, a lower alkylsulfonyl group, a lower alkylcarbonyloxy group and an amino group being optionally substituted by a lower alkyl group, n is 0, 1 or 2, and m is an integer of 0 to 5, or its ester, or a salt thereof.