Patent ID: 6479531
Filing Date: 2002-11-12
Classification: A61P,C07D

Abstract:
A compound of the formula (I) whereinX and Y are independently &boxH;Nâ€”, â€”N(R5)â€” (R5 being selected from H, Me, Et, Pr, Bn, â€”OH and â€”CH2COOR6, wherein R6 represents H, Me, Et, Pr or Bn), n is from 1 to 4; R1 is H or C1 to C15 hydrocarbyl wherein up to three C atoms may optionally be replaced by N, O or S atoms and up to three H atoms may optionally be replaced by halogen atoms; R2 is selected from H, Me, Et, Pr and OH, each R2 being independently selected from H, Me, Et, Pr and OH when n is greater than 1; R3 (when n is 1) is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 is independently selected from H, Me, Et and Pr, or two R3 groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocylic ring, or two R3 groups are absent from neighbouring carbon atoms which are linked by a double bond; or R2 and R3 on the same carbon atom together represent an &boxH;O group; R4 is C1 to C15 hydrocarbyl wherein up to two C atoms may optionally be replaced by N, O or S atoms and up to two H atoms may optionally be replaced by halogen atoms; Z is (NR7)aâ€”COâ€”(NR8)bâ€” (wherein a is 0 or 1, b is 0 or 1, and R7 and R8 are independently selected from the groups recited above for R6), â€”COâ€”NR7â€”CH2â€”COâ€”NR8â€”, â€”COâ€”Oâ€”, â€”CH2â€”CH2â€”, â€”CH&boxH;CHâ€”, â€”CH2â€”NR8â€” or a bond; Q is â€”R9V, or (wherein R9 is â€”CH2â€”; â€”CH2â€”CH2â€”; or â€ƒor R9 and R8, together with the nitrogen atom to which R8 is attached, form a pyrrolidine ring which is substituted by V; V is â€”COâ€”NHâ€”SO2â€”Ph, â€”SO2â€”NHâ€”COâ€”Ph, â€”CH2OH, or a group of the formula â€”R10U, (wherein U is â€”COOH, tetrazolyl, â€”CONHOHâ€” or â€”SO3H; and R10 is a bond; C1 to C6 hydrocarbylene, optionally substituted by hydroxy, amino or acetamido; â€”Oâ€”(C1 to C3 alkylene)â€”; â€”SO2NR11â€”CHR12â€”; â€”COâ€”NR11â€”CHR12â€”, R11 and R12 being independently selected from H and methyl; or â€”NHâ€”(CO)câ€”CH2â€”, c being 0 or 1); T is C1 to C6 hydrocarbyl, â€”NR6R7 (wherein R6 and R7 are as defined above), â€”OMe, â€”OH, â€”CH2OH, halogen or trihalomethyl; m is 1 or 2; p is from 0 to 3; and q is from 0 to 2, with the proviso that q is 1 or 2 when Z is a bond); or a pharmaceutically acceptable salt thereof.