Patent ID: 7932096
Filing Date: 2011-04-26
Classification: A61K,B01J,B22F,B82Y

Abstract:
1. A purified nanocluster functionalized with a single DNA strand comprising: a purified nanocluster, wherein said nanocluster is coated with a monolayer of trioxyethylene-thiol molecules, said nanocluster being functionalized with a single mono-thiol-modified DNA strand, said mono-thiol-modified DNA strand having a length from about 10 bases to about 50 bases, wherein the purified nanocluster functionalized with a single DNA strand is obtained by combining the single mono-thiol-modified DNA strand with the nanocluster coated with the monolayer of trioxyethylene-thiol molecules to form a mixture; combining said mixture with a binary solvent system comprising an aqueous phase and an organic phase; and separating the aqueous phase and the organic phase, wherein the organic phase comprises said at least one nanocluster functionalized with a single DNA strand.