Patent ID: 8173360
Filing Date: 2012-05-08
Classification: A61K,A61P,C07D,G01N

Abstract:
1. A method of screening a test compound as a cell death inhibitor, the method comprising determining whether the test compound binds to macrophage migration inhibitory factor, and determining whether the test compound promotes expression of a gene under control of an antioxidant response element selected from the group consisting of Heme oxygenase-1, Liver glutathione S-transferase Ya subunit, Liver glutathione S-transferase Yc subunit, Glutathione S-transferase Yb subunit, Glutathione S-transferase Yc1 subunit, Gamma-glutamylcysteine synthetase, NAD(P)H: quinone reductase, UDP-glucuronosyltransferase, exon 1, Bilirunin-specific UDP-glucuronosyltransferase and NAD(P)H-menadione oxidereductase, wherein binding to macrophage migration inhibitory factor and promoting expression of the gene under control of an antioxidant response element indicates that the test compound is a cell death inhibitor.