Patent ID: 6468999
Filing Date: 2002-10-22
Classification: A61P,C07C,C07D

Abstract:
A 9-arylsulfone of the formula (XII) where R3 is:(1) â€”H, (2) C1-C4 alkyl, where RN is:(1) â€”H, (2) C1-C4 alkyl, where Rx is:(1) â€”H (2) â€”F, â€”Cl, â€”Br, â€”I, (3) â€”Oâ€”Rxâˆ’1 where Rxâˆ’1 is: â€”H, C1-C4 alkyl, â€”&phgr;, (4) â€”CF3, (5) -COâ€”NRxâˆ’2Rxâˆ’3 where Rxâˆ’2 and Rxâˆ’3 are â€”H and C1-C4 alkyl, and where Rxâˆ’2 and Rxâˆ’3 are taken with the attached nitrogen atom to form a ring selected from the group consisting of 1-pyrrolidinyl, 1-piperazinyl and 1-morpholinyl,(6) â€”NHâ€”SO2â€”Rxâˆ’4 where Rxâˆ’4 is â€”H and C1-C4 alkyl, (7) â€”NRxâˆ’2Rxâˆ’3 where Rxâˆ’2 and Rxâˆ’3 are as defined above, (8) â€”NRxâˆ’4â€”COâ€”Rxâˆ’4 where Rxâˆ’4 is as defined above, (9) â€”SO2â€”NRxâˆ’2Rxâˆ’3 where Rxâˆ’2 and Rxâˆ’3 are as defined above, (10) â€”Câ‰¡N, (11) â€”NO2; where R9 is:â€”H, â€”F, â€”Cl, C1-C4 alkyl, C1-C3 alkoxy, â€”CF3, â€”OR9-1, where R9-1, is as defined above, â€”COâ€”NR9-2R9-3 where R9-2 and R9-3 are as defined above, â€”NR9-2R9-3 where R9-2 and R9-3 are as defined above, â€”NHâ€”SO2â€”R9-4 where R9-4 is as defined above, â€”NHâ€”CO2â€”R9-2 where R9-2 is as defined above and pharmaceutically.