Patent ID: 6559280
Filing Date: 2003-05-06
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
A compound for activating ubiquitination of a target protein comprising;a) a ubiquitination recognition element which is able to bind to either the E3 or E2 functional elements of the ubiquitination system, wherein said ubiquitination recognition element has a molecular weight less than 30,000 and has a binding affinity for said E3 and/or E2 elements of the ubiquitination system of at least 102 Mâˆ’1, and; b) a target protein binding element that is able to bind specifically to a target protein wherein said target protein binding element has a molecular weight of less than 30,000 and has a binding affinity for said target protein greater than 105 Mâˆ’1, wherein said ubiquitination recognition element is covalently linked to said target protein binding element.