Patent ID: 6310058
Filing Date: 2001-10-30
Classification: C07D

Abstract:
The compound of the formula ##STR25##wherein R is a 2-phenyloxazoline of the formula (1a) ##STR26##or a 2-phenyloxazole of the formula (1b) ##STR27##wherein R.sub.1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, carboxy, amino, mono- or dialkylamino, aminocarbonyl, mono- or dialkylaminocarbonyl, or C.sub.1 -C.sub.4 alkyl substituted by one or two phenyl groups;R.sub.2 and R.sub.3 independently are hydrogen or C.sub.1 -C.sub.3 alkyl;p and q independently are 0, 1 or 3;R.sub.4 is a siderophoric group of the formula--(CH.sub.2).sub.m --N(OH)--C(O)--(CH.sub.2).sub.n --(CH.dbd.CH).sub.o --CH.sub.3wherein m is an integer of from 2 to 6, n is 0 or an integer of from 1 to 22, and o is 0 or an integer 1 to 4, provided that m+o is no greater than 25;X.sub.1 is O or NH;Y is H or C.sub.1 -C.sub.4 alkyl;Z is H, lower alkyl, mono- or dialkylamino, or --N(R.sub.5)(R.sub.5 ') when X.sub.1 is NH; and when X.sub.1 isO, Z is mono- or dialkylamino or --NR.sub.5)(R.sub.5 ');wherein R.sub.5 is hydrogen, lower alkyl, alkyloxycarbonyl, aryloxycarbonyl,aralkyloxycarbonyl, cycloalkoxycarbonyl, bicycloalkyloxycarbonyl, or lower alkanoyl;R.sub.5' is hydrogen or lower alkyl;or the pharmaceutically acceptable salts thereof.