Patent ID: 8691868
Filing Date: 2014-04-08
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of formula I: where: R R 10 is selected from —C 1-6 alkyl, —O—C 1-6 alkyl, —C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 11 R 12 , —CH(R 15 )—NH 2 , —CH(R 15 )—NHC(O)O—C 1-6 alkyl, and —CH(NH 2 )CH 2 COOCH 3 ; and R 11 and R 12 are independently selected from H, —C 1-6 alkyl, and benzyl; or R 11 and R 12 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 O(CH 2 ) 2 —; R 13 is selected from —O—C 1-6 alkyl, —O-benzyl, and —NR 11 R 12 ; and R 14 is —C 1-6 alkyl or —C 0-6 alkylene-C 6-10 aryl; R 15 is H, —CH 3 , —CH(CH 3 ) 2 , phenyl, or benzyl; R R R R Z is selected from —CH— and —N—; R R 40 is selected from —C 1-6 alkyl, —O—C 1-6 alkyl, —C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 41 R 42 , —CH(R 45 )—NH 2 , —CH(R 45 )—NHC(O)O—C 1-6 alkyl, and —CH(NH 2 )CH 2 COOCH 3 ; and R 41 and R 42 are independently selected from H, —C 1-6 alkyl, and benzyl; or R 41 and R 42 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 O(CH 2 ) 2 —; R 43 is selected from —O—C 1-6 alkyl, —O-benzyl, and —NR 41 R 42 ; and R 44 is —C 1-6 alkyl or —C 0-6 alkylene-C 6-10 aryl; R 45 is H, —CH 3 , —CH(CH 3 ) 2 , phenyl, or benzyl; a is 0 or 1; R b is 0 or an integer from 1 to 3; each R where each alkyl group in R where the methylene linker on the biphenyl is optionally substituted with one or two —C or a pharmaceutically acceptable salt thereof.