Patent ID: 6774211
Filing Date: 2004-08-10
Classification: C07K

Abstract:
A compound of formula (I)N-Ac-Sar-Gly-AA3-AA4-AA5-AA6-AA7-Arg-Pro-AA10â€ƒâ€ƒ(I), or a pharmaceutically acceptable salt, ester, prodrug, or solvate thereof, whereinAA3 is selected from the group consisting of (1) glutaminyl, (2) phenylalanyl, (3) valyl, and (4) asparaginyl; AA4 is selected from the group consisting of (1) D-isoleucyl, (2) isoleucyl, (3) D-leucyl, and (4) D-alloisoleucyl; AA5 is selected from the group consisting of (1) seryl, (2) methionyl, (3) allothreonyl, (4) threonyl, and (5) tyrosyl; AA6 is selected from the group consisting of (1) norvalyl, (2) seryl, (3) tryptophyl, (4) glutaminyl, and (5) prolyl; AA7 is selected from the group consisting of (1) isoleucyl, (2) D-isoleucyl, (3) lysyl(acetyl), and (4) prolyl; and AA10 is selected from the group consisting of (1) D-alanylamide, (2) ethylamide, and (3) isopropylamide; with the proviso that one of AA4 and AA7 is a D-amino acid.