Patent ID: 7541343
Filing Date: 2009-06-02
Classification: A61K,A61P,C12N,G01N

Abstract:
1. A method of preventing or reducing cellular proliferation of smooth muscle cells, breast cancer cells or prostate cancer cells, the method comprising locally administering to smooth muscle cells, breast cancer cells or prostate cancer cells a composition comprising a nucleic acid sequence encoding human YY1 comprising the amino acid sequence as set forth in SEQ ID NO: 2, the nucleic acid sequence being operatively linked to control sequences which promote expression of YY1, wherein administering the composition to the smooth muscle cells results in expression of YY1 in said smooth muscle cells, thereby preventing or reducing cellular proliferation of the smooth muscle cells; wherein administering the composition to the breast cancer cells results in expression of YY1 in said breast cancer cells, thereby preventing or reducing cellular proliferation of the breast cancer cells; and wherein administering the composition to the prostate cancer cells results in expression of YY1 in said prostate cancer cells, thereby preventing or reducing cellular proliferation of the prostate cancer cells.