Patent ID: 6214865
Filing Date: 2001-04-10
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR157##wherein A is a C.sub.1-6 saturated or C.sub.2-6 unsaturated hydrocarbon skeleton, said skeleton being unsubstituted or having between 1 and 10 substituents, inclusive, independently selected from cyano, halo, azido, oxo, and Q.sub.1 ;each Q.sub.1 is independently selected from OR.sub.1, SR.sub.1, SO.sub.2 R.sub.1, OSO.sub.2 R.sub.1, NR.sub.2 R.sub.1, NR.sub.2 (CO)R.sub.1, NR.sub.2 (CO)(CO)R.sub.1, NR.sub.4 (CO)NR.sub.2 R.sub.1, NR.sub.2 (CO)OR.sub.1, (CO)OR.sub.1, O(CO)R.sub.1, (CO)NR.sub.2 R.sub.1, and O(CO)NR.sub.2 R.sub.1 ;each of R.sub.1, R.sub.2, R.sub.4, R.sub.5, and R.sub.6 is independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 aminoalkyl, C.sub.6-10 aryl, C.sub.6-10 haloaryl, C.sub.6-10 hydroxyaryl, C.sub.1-3 alkoxy-C.sub.6 aryl, C.sub.6-10 aryl-C.sub.1-6 alkyl, C.sub.1-6 alkyl-C.sub.6-10 aryl, C.sub.6-10 haloaryl-C.sub.1-6 alkyl, C.sub.1-6 alkyl-C.sub.6-10 haloaryl, (C.sub.1-3 alkoxy-C.sub.6 aryl)-C.sub.1-3 alkyl, C.sub.2-9 heterocyclic radical, C.sub.2-9 heterocyclic radical-C.sub.1-6 alkyl, C.sub.2-9 heteroaryl, and C.sub.2-9 heteroaryl-C.sub.1-6 alkyl;each of D and D' is independently selected from R.sub.3 and OR.sub.3, wherein R.sub.3 is H, C.sub.1-3 alkyl, or C.sub.1-3 haloalkyl;n is 0 or 1;E is R.sub.5 or OR.sub.5 ;G is O, S, CH.sub.2, or NR.sub.6 ;each of J and J' is independently H, C.sub.1-6 alkoxy, or C.sub.1-6 alkyl; or J and J' taken together are .dbd.CH.sub.2 or --O-(straight or branched C.sub.1-5 alkylene)-O--;Q is C.sub.1-3 alkyl;T is ethylene or ethenylene, optionally substituted with (CO)OR.sub.7, where R.sub.7 is H or C.sub.1-6 alkyl;each of U and U' is independently H, C.sub.1-6 alkoxy, or C.sub.1-6 alkyl; or U and U' taken together are .dbd.CH.sub.2 or --O-(straight or branched C.sub.1-5 alkylene)-O--;X is H or C.sub.1-6 alkoxy;each of Y and Y' is independently H or C.sub.1-6 alkoxy; or Y and Y' taken together are .dbd.O, .dbd.CH.sub.2, or --O-(straight or branched C.sub.1-5 alkylene)-O--; andeach of Z and Z' is independently H or C.sub.1-6 alkoxy; or Z and Z' taken together are .dbd.O, .dbd.CH.sub.2, or --O-(straight or branched C.sub.1-5 alkylene)-O--;or a pharmaceutically acceptable salt thereof.