Patent ID: 7868021
Filing Date: 2011-01-11
Classification: A61P,C07D

Abstract:
1. A compound having the following formula: wherein: (a) X is selected from the group consisting of (b) R1 is selected from the group consisting of C (c) R3 is hydrogen or hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C (e) R6 is hydrogen; (f) R8 is selected from the group consisting of chloro, bromo, methoxy, methylthio, C (g) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C (h) each R9 is independently selected from the group consisting of hydrogen, C (j) a R7 moiety described in (g) and a R9 moiety described in (h) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to 5 ring carbons and 0 or 1 ring nitrogen, but if such rings are fused, R8 is other than chloro or bromo; an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.