Patent ID: 8289519
Filing Date: 2012-10-16
Classification: G01N

Abstract:
1. A surface plasmon resonance (SPR) microscopy system comprising: an integrated microfluidic chip that includes a plurality of layers, wherein the microfluidic chip includes at least a first layer and a second layer, wherein the first layer includes a plurality of microfluidic channels, wherein the second layer includes one or more flow control components, wherein an array of metal spots is disposed on a side of the channels in the first layer, and an SPR imaging system, wherein the SPR imaging system is adapted to detect an SPR signal associated with each metal spot, and a pressure manifold to actuate flow control components in the second layer of the microfluidic chip and to realize pressure-driven flow of liquids in the channels in the first layer of the microfluidic chip, wherein the plurality of microfluidic channels in the first layer of the microfluidic chip includes a first set of channels and a second set of channels, wherein the first set of channels and the second set of channels are in communication at a position where a channel of the first set of channels and a channel of the second set of channels intersect one another, and wherein a metal spot of the array of the metal spots is located at the position where the first set of channels and the second set of channels perpendicularly intersect one another.