Patent ID: 9096658
Filing Date: 2015-08-04
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method of screening a pool of antibodies for antibodies or fragments thereof for use in prevention, treatment or amelioration of one or more symptoms associated with a respiratory syncytial virus (RSV) infection in a patient, wherein the antibodies specifically bind to an RSV F peptide, the method comprising: a. bringing said RSV F peptide into contact with said pool of antibodies or antibody fragments, said RSV F peptide consisting of an amino acid sequence having the following structure: NSELX SLIXD MPITX DQKXL MXNN (SEQ ID NO:34) where X at position 5 may be either a leucine or a serine; where X at position 9 may be an asparagine, a histidine, an alanine, a serine, an arginine, an aspartic acid, a lysine, a tyrosine, or a glutamine; where X at position 15 may be an asparagine or an isoleucine; where X at position 19 may be a glutamic acid, a glutamine, an aspartic acid, a threonine, a methionine, a lysine, or a tyrosine; and where X at position 22 may be a serine, a glutamic acid, or a phenylalanine; b. detecting whether one or more of said antibodies or fragments thereof specifically bind to said RSV F peptide; c. determining an EC d. selecting one or more antibodies or fragments thereof that have an EC