Patent ID: 6613781
Filing Date: 2003-09-02
Classification: A61P,C07D

Abstract:
A compound of formula I wherein Q is SO2, CO, CONR24, CSNR25; W is N or CR7; X is N or CR9; Y is NR or CR10R29; Z is NR21 or CR11R30 with the proviso that when Y is NR then Z must be CR11R30 and with the further proviso that at least one of Y and Z must be NR or NR21; n is an integer of 1 or 2; R and R21 are each independently H, CNR26NR27R28, or a C1-C6alkyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R1, R2 and R9 are each independently H, halogen, CN, OCO2R12, CO2R13, CONR22R23, CNR14NR15R16, SOmR17, NR18R19, OR20, or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6-cycloalkyl, cycloheteroalkyl, C1-C6alkanoyl, aryl or heteroaryl group each optionally substituted; m is 0 or an integer of 1 or 2; R3 and R4 are each independently H, halogen, C1-C4alkyl or C1-C4haloalkyl or R3 and R4 may be taken together with the atom to which they are attached to form a carbonyl group; R5 and R6 are each independently H or an optionally substituted C1-C6alkyl group; R7 is H, halogen, or a C1-C6alkyl, C1-C6alkoxy, aryl or heteroaryl group each optionally substituted; R8 is an optionally substituted C1-C6alkyl, aryl or heteroaryl group; R10, R11, R29 and R30 are each independently H or an optionally substituted C1-C6alkyl group; R12, R13 and R17 are each independently H or an optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group; R14, R15, R16, R18, R19, R26, R27 and R28 are each independently H or C1-C4alkyl; R20, R22 and R23 are each independently H or an optionally substituted C1-C6alkyl group; R24 and R25 are each independently H or an alkyl, aryl or heteroaryl group each optionally substituted; and --- represents a single bond or a double bond; or a pharmaceutically acceptable salt thereof.