Patent ID: 7229974
Filing Date: 2007-06-12
Classification: A61K,A61P,C07H,C12N

Abstract:
1. An oligonucleotide of the formula wherein the Oligo is a nucleotide sequence between 10 to 40 nucleotides in length whose 5′ end and 3′ end are Gn, where n is an integer between 0 to 40 and is the number of guanines which occurs at the 5′ or 3′ end of the Oligo, wherein each CAP is G(m-n) where m is an integer and is defined independently of each other, wherein the a 3′ or 5′ phosphoric diester bridge in each CAP is completely or partially replaced by phosphorothioate bridges, wherein (i) m is no greater than ten and may not be zero at both the 5′ and 3′ ends when n is zero at both the 5′ and 3′ ends of the Oligo and, (ii) m-n is zero when n is no smaller than ten at either the 5′ or 3′ end of the Oligo, wherein Oligo is