Patent ID: 6166203
Filing Date: 2000-12-26
Classification: C07D

Abstract:
A compound of formula: ##STR56## or the pharmaceutically acceptable non-toxic salts thereof wherein: n is 0 or an integer of from 1-3;X is carbon, nitrogen, or oxygen;Z is an electron pair when X is oxygen;Z is hydrogen, provided that when X is carbon, Z is not hydrogen;Z is aryl, which is unsubstituted or substituted with one or two groups independently selected from lower alkyl, lower alkoxy, or halogen; orZ is ##STR57## where Y is oxygen or sulfur;R is lower alkyl, hydroxy, lower alkoxy, hydroxyalkyl, or aminoalkyl;R is aryl or heteroaryl, each of which is mono or disubstituted independently with halogen, thio, hydroxyl, lower alkyl, lower alkoxy, or amino;R is amino which is unsubstituted or substituted with one or two groups independently selected from lower alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, haloalkyl, hydroxy, aminoalkyl, or amidoalkyl;heteroaryl, arylalkyl or heteroarylalkyl, each of which is unsubstituted or substituted with one or two groups independently selected from halogen, thio, hydroxyl, lower alkyl, lower alkoxy, or amino; ora carbocyclic group having from 3-7 member atoms, where up to two of which atoms are hetero atoms selected from oxygen and nitrogen and where any member of the carbocyclic group is unsubstituted or substituted with halogen, lower alkyl or lower alkoxy; orR is a carbocyclic group having from 3-7 member atoms, where up to three of which members are hetero atoms selected from oxygen and nitrogen and where any member of the carbocyclic group is unsubstituted or substituted with halogen, lower alkyl, or lower alkoxy;A and B are the same or different and represent hydrogen, or lower alkyl;the C ring represents a thiophene, pyridine, or pyrimidine ring; andW is aryl, heteroaryl, 2- or 3-thienyl, or 2-, 3-, or 4-pyridyl, each of which is unsubstituted or mono or disubstituted independently with halogen, hydroxyl, lower alkyl, lower alkoxy, amino, or mono- or dialkylamino where each alkyl portion is lower alkyl.