Patent ID: 7780983
Filing Date: 2010-08-24
Classification: A61K,A61P,Y10T

Abstract:
1. Amphoteric liposomes loaded with nucleic acids, wherein the liposomes comprise at least one amphipathic cationic lipid, at least one amphipathic anionic lipid, and at least one neutral lipid, and wherein the liposomes are stable at pH 4.2 and pH 7.5 and are prepared by a process comprising the steps of: a. providing a mixture of at least one amphipathic cationic lipid, at least one amphipathic anionic lipid, at least one neutral lipid, and nucleic acids and at least one solvent, wherein said mixture has a pH between about 3-6 b. forming liposomes in said mixture; and c. changing the pH of said liposomes to pH 7-9.