Patent ID: 6103699
Filing Date: 2000-08-15
Classification: A61K,C07K

Abstract:
A method of inhibiting cell proliferation comprising administering an effective amount of a peptide of the formula I:X--A--D--Trp--Y (I)wherein X is selected from the group comprising hydrogen, glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tryptophan, .gamma.-aminobutyric acid, and .xi.-aminocaproic acid; A is selected from the group comprising D-glutamic acid and D-iso-glutamic acid; and Y is selected from the group comprising glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tyrptophan, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, hydroxyl and an amide group, to a person or cell in need thereof.