Patent ID: 6794529
Filing Date: 2004-09-21
Classification: C07F

Abstract:
A process for the preparation of an organic boronic acid ester, organic boronic thioester or organic boronic acid amide comprising reacting a penta- or hexa-substituted diboron compound of formula (i) or (ii) or a mixture of diboron compounds of formula (i) and (ii), wherein M is a counterion and Nu is a nucleophile, and each X, which is the same or different, is O, S(O)n, where n is 1 or 2 or NRâ€³ where Râ€³ is hydrogen or C1-C12 alkyl, and each R is the same or different and is independently selected from hydrogen, optionally substituted alkyl, optionally substituted aryl or represents a cyclic group of the formula where X and Nu are as defined above and Râ€² is optionally substituted alkylene, optionally substituted arylene or other divalent group consisting of aliphatic moieties linked to aromatic moieties; with an organic compound having at a coupling position a halogen substituent or other substituent which undergoes substitution with the penta- or hexa-substituted diboron compound of formula (i) and/or formula (ii) in the presence of a Group VIII metal catalyst, such that a direct carbon to boron bond is formed between said coupling position and a boron-containing residue of the penta- or hexa-substituted diboron compound of formula (i) and/or formula (ii).