Patent ID: 6232467
Filing Date: 2001-05-15
Classification: C07B,C07C,C07D,C07H,C40B

Abstract:
A process for producing a compound of formula 1 comprising: ##STR181##providing compounds of formula 13 and formula 14 ##STR182##where R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, acyl, acylalkyl, carboxy, carboxamido, trialkylsilyl, aryldialkylsilyl, diarylalkylsilyl, triarylsilyl, phosphinyl, and --YR, where Y is selected from the group consisting of --O--, --NR.sub.a --, --S--, --SO--, and --SO.sub.2 --, and R and R.sub.a are each independently selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, and acyl, or R.sup.1 and R.sup.2 together form a bridge of 2 to 20 carbon atoms; andwhere R.sup.3 and R.sup.4 are each independently selected from the group consisting of hydrogen, carboxy, carboxamido, alkyl, cycloalkyl, aryl and heteroaryl, provided that the compound of formula 14 is not paraformaldehyde;providing a compound of formula 15 or a compound of formula 19 ##STR183##where R.sup.5 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkenyl, alkynyl and allenyl; R.sup.6, R.sup.7 and R.sup.8 are selected from the group consisting of hydroxy, alkoxy, aryloxy, heteroaryloxy, chloro, bromo, fluoro, iodo, carboxy, amino, alkyl-amino, dialkylamino, acylamino, carboxamido, thio, alkylthio, arylthio, acylthio, alkyl, cycloalkyl, aryl, and heteroaryl, or together form a methylene bridge of 3 to 7 atoms; X is a positive counter ion, and n is 0 or 1;mixing said compounds of formula 13, formula 14, and formula 15 or 19 to form a reaction mixture; and allowing the reaction mixture to react to form the compound of formula 1.