Patent ID: 6797828
Filing Date: 2004-09-28
Classification: C07C,C07D

Abstract:
A process for the preparation characterized in that a compound represented by formula (II): wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group of C1 to C10 which may have substituents, a hydrocarbon group of C3 to C14 having alicyclic skeletons, an alkynyl group which may have substituents, an aryl group which may have substituents, an aralkyl group which may have substituents, a heterocyclic group which may have substituents, a heterocyclic alkyl group which may have substituents, an N-unsubstituted or substituted carbamoyl group, or an alkoxycarbonyl group and/or an inorganic salt thereof are cyclized and hydrolyzed in an aqueous basic solution involving 1-10 moles of a basic compound per 1 mole of the compound represented by formula (II), in a process for preparing a compound represented by formula (I): wherein R1 and R2 are the same as defined above, andwherein a process for preparing the compound represented by the formula (II) comprises one of the following: a) a compound represented by formula (III) wherein R1 represents the same as defined above and R3 represents an alkyl group of C1 to C6, is reacted with ammonia in C1 to C5 alcohol, wherein R1 represents the same as defined above and R2 represents a hydrogen atom; b) a compound of the formula (V): R1CN wherein R1 represents an alkyl group of C1 to C10 which may have substituents a hydrocarbon group of C3 to C14 having alicyclic skeletons, an alkenyl group which may have substituents, an alkynyl group which may have substituents, an aryl 2group which may have substituents, an aralkyl group which may have substituents, a heterocyclic group which may have substituents, a heterocyclic alkyl group which may have substituents, an N-unsubstituted or substituted carbamoyl group, or an alkoxycarbonyl group, is reacted with diaminomaleonitrile in the presence of an acid; and c) diaminomaleonitrile and a compound represented by formula (VI): R1CONHR2 wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group of C1 to C10 which may have substituents, a hydrocarbon group of C3 to C14 having alicyclic skeletons, an alkenyl group which may have substituents an alkynyl group which may have substituents, an aryl group which may have substituents, an aralkyl group which may have substituents, a heterocyclic group which may have substituents, a heterocyclic alkyl group which may have substituents, an N-unsubstituted or substituted carbamoyl group, or an alkoxycarbonyl group, are reacted with a compound selected from the group consisting of phosphorous oxychloride, phosphorous trichloride, phosphorous pentachloride, phosphorous oxybromide, diphosphoryl chloride, sulfonyl chloride, sulfuryl chloride, phosgene, diphosgene, triphosgene, and chloroformate trichloromethyl ester.