Patent ID: 7342011
Filing Date: 2008-03-11
Classification: A61P,C07D

Abstract:
1. A compound having the Formula (I): or a pharmaceutically acceptable salt thereof, wherein A is H, OH, O—(C W is O, S, or NR X is H or COR Y is H, OR Z is H, OR R R wherein, each of m and n is independently an integer selected from 0 and 1, wherein, when each of m and n is 1, each of R R R R R R R each of R R R R or when m is 0 and n is 1, R each of R R R R R —CH R R R or A is OH; X is H; W, Y, and Z are defined as above; and R wherein R 21 is H, C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl, R 20 is H, C 1 -C 6 alkyl, COR 19 , CO 2 19 , or CONHR 19 , CSR 19 , COSR 19 , CSOR 19 , CSNHR 19 , SO 2 R 19 , or SO 2 NHR 19 , wherein R 19 is C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl; or A is OH; X is COCH W, Y, and Z are defined as above; and R wherein R 21 is H, C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl, R 20 is H, C 1 -C 6 alkyl, COR 19 , CO 2 R 19 , or CONHR 19 , CSR 19 , COSR 19 , CSOR 19 , CSNHR 19 , SO 2 R 19 , or SO 2 NHR 19 , wherein R 19 is C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl; or A is H or OH; X is H or COCH W, Y, and Z are defined as above; and R with the proviso that one or both of Y and Z are Hal; or A is H or OH; X is H or COCH W, Y, and Z are defined as above; and R wherein R 22 is H, C 1 -C 6 alkyl, C 6 -C 12 aryl, C 1 -C 4 alkaryl, COR 24 , CO 2 R 24 , CONHR 24 , CSR 24 , COSR 24 , CSOR 24 , CSNHR 24 , SO 2 R 24 , or SO 2 NHR 24 , wherein R 24 is C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl, and r is 1-2; or A is H or OH; X is H or COCH W, Y, and Z are defined as above; and R wherein R 21 is H, C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl; or A is H or OH; X is H or COCH W, Y, and Z are defined as above; and R wherein ═E is ═O or (H,H), R 22 is H, C 1 -C 6 alkyl, C 6 -C 12 aryl, C 1 -C 4 alkaryl, COR 24 , CO 2 R 24 , CONHR 24 , CSR 24 , COSR 24 , CSOR 24 , CSNHR 24 , SO 2 R 24 or SO 2 NHR 24 , wherein R 24 is C 1 -C 6 alkyl, C 6 -C 12 aryl, or C 1 -C 4 alkaryl, r is 1-2, and s is 0-1; or A is H or OH; X is H or COCH W, Y, and Z are defined as above; and R