Patent ID: 6455032
Filing Date: 2002-09-24
Classification: A61K,A61P,A61Q

Abstract:
A composition for application to the skin following UV exposure or for oral administration prior to or following UV exposure, which composition comprises a compound of the general Formula (I) in whichZ is H, R1 is H, or RACO where RA is C1-10 alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from W is H, and A and B taken together form a six membered ring selected from W, A and B taken with the groups with which they are associated comprise W and A taken together with the groups with which they are associated comprise and B is whereinR3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10 alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10 alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10 alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and R are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10 alkyl, X is preferably O, but may be N or S, and Y is whereR7 is H, or C1-10 alkyl, in association with a dermatologically acceptable or pharmaceutically acceptable carrier.