Patent ID: 6673781
Filing Date: 2004-01-06
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I): wherein R1 is a group selected from (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, and heterocyclic groups, (b) the groups represented by (a) each substituted independently with at least one group selected from non-interfering substituents, or (c) â€”(CH2)mâ€”R5 wherein m is an integer from 1 to 6, and R5 is a group selected from the groups (a) and (b); one of R3 and R4 is â€”(L2)-(acidic group) wherein L2 is represented by the formula: wherein M is â€”CH2â€”, â€”Oâ€”, â€”N(R15)â€”, or â€”Sâ€”; R13 and R14 are each independently a hydrogen atom, C1 to C10 alkyl, aryl, aralkyl, carboxy, or halogens, wherein R15 is a hydrogen atom or C1 to C6 alkyl; and acidic group is represented by the formula: wherein R16 is hydrogen atom, a metal, or C1 to C10 alkyl; R17 is independently a hydrogen atom or C1 to C10 alkyl; h is an integer from 1 to 8 and the other is a hydrogen atom, A ring is a group represented by the formula: wherein R2 is CONH2 or CONHNH2; R18, R19, R20, R21, R22, and R23 are each independently a hydrogen atom, or lower alkyl; R24 and R25 are each independently a hydrogen atom, C1 to C6 alkyl, aryl, a halogen or aralkyl; its prodrug, their pharmaceutically acceptable salt, or hydrate thereof.