Patent ID: 6794415
Filing Date: 2004-09-21
Classification: A61P,C07C

Abstract:
A method of treating osteoporosis in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount to treat osteoporosis of a compound selected from the group consisting of a compound of the formula: wherein R1 and R2 are individually selected from the group consisting of a) hydrogen, halogen, â€”OH, â€”CF3, NO2, â€”NH2, alkoxy of 1 to 8 carbon atoms, alkylthio of 1 to 8 carbon atoms, wherein RA and RB are individually alkyl of 1 to 8 carbon atoms or together with the nitrogen to which they are attached form a saturated or unsaturated heterocycle of 5 to 6 ring members optionally containing a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen, b) optionally substituted alkyl, alkenyl and alkynyl of up to 8 carbon atoms, c) optionally substituted aryl of 6 to 14 carbon atoms, optionally substituted aralkyl of 7 to 15 carbon atoms, â€”CH(OH)â€”Y and Y is selected from the group consisting of i) optionally substituted alkyl, alkenyl and alkynyl of up to 8 carbon atoms and ii) optionally substituted aryl of 6 to 14 carbon atoms or R1 and R3 form â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, R3 and R4 are individually selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, R6 and R7 are individually hydrogen or halogen, R8 is hydrogen or optionally substituted benzyl and R5 is selected from the group consisting of â€”[A]â€”CHO, â€”[A]â€”CH3, â€”[A]â€”C(OH)ZZâ€² and â€”[A]â€”is selected from the group consisting of a single bond and alkylene, alkenylene and alkynylene of up to 8 carbon atoms and Z, Zâ€² and Zâ€³ are individually selected from the group consisting of a) hydrogen and alkyl, alkenyl and alkynyl of up to 8 carbon atoms and b) optionally substituted aryl of 6 to 14 carbon atoms and its non-toxic, pharmaceutically acceptable addition salts with acids and bases with the proviso that compounds wherein R5 is and A is a single bond, Zâ€³ is alkyl of 1 to 8 carbon atoms and R1 to R8 are all hydrogen are excluded.