Patent ID: 6355618
Filing Date: 2002-03-12
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein:R1 is an optionally substituted alkyl or hydrogen; R2 is hydrogen or optionally substituted alkyl; R3 is an alkyl, saturated carbocyclic, partially saturated carbocyclic, aryl, saturated heterocyclic, partially saturated heterocyclic or heteroaryl group, wherein said group is optionally substituted; X is O, S, NR4 or (CR4R5)n, where R4 and R5 are, at each occurrence, independently selected from the group consisting of hydrogen, alkyl and cycloalkyl, and n is 0; or X is NR4, and R3 and R4 are taken together with the nitrogen atom to which they are attached to form a saturated heterocyclic, partially saturated heterocyclic or heteroaryl group, wherein said group is optionally substituted; or X is CR4R5, and R3 and R4 are taken together with the carbon atom to which they are attached to form a saturated carbocyclic, partially saturated carbocyclic, aryl, saturated heterocyclic, partially saturated heterocyclic or oxygen-containing heteroaryl group, wherein said group is optionally substituted; and Y is a residue of valine; provided that when X is O, then R3 is not unsubstituted benzyl or t-butyl; and â€”Xâ€”R3 is other than unsubstituted or substituted indolyl.