Patent ID: 6475779
Filing Date: 2002-11-05
Classification: A61K

Abstract:
A preparation of microparticles, each of which preparation of microparticles comprise a synthetic polymeric matrix and an effective amount of naked DNA dispersed within the preparation of microparticles, the polymeric matrix being dissolvable in a volatile organic solvent, wherein(a) the size of the microparticles is between 1 and 300 &mgr;m in diameter; and (b) the effective amount of naked DNA dispersed within the preparation of microparticles is greater than 20 &mgr;m and wherein the DNA contains a gene operably linked to a promoter, the nucleotide sequence of said gene being greater than 30 nucleotides in length, said naked DNA comprising circular nucleic acid molecules, supercoiled nucleic acid molecules, or a combination of both.