Patent ID: 6689557
Filing Date: 2004-02-10
Classification: A01K,A61K,A61P,C07K,C12N,Y10T

Abstract:
A method of identifying a substance which affects long term memory in an animal selected from the group consisting of Drosophila, Aplysia, and rodents comprising determining that said substance alters induction or activity of an activator or a repressor from normal in said animal, wherein said activator is a CREB/CREM/ATF-1 subfamily member associated with potentiation of long term memory and said repressor is a CREB/CREM/ATF-1 subfamily member associated with blocking long term memory; comprising the following steps:(a) treating said animal with a test substance, (b) measuring long term memory in said animal, (c) determining the activity of said CREB/CREM/ATF-1 subfamily member, (d) examining the results from steps (b) and (c), and if correlated, said test substance meets the selection criteria of the instant method.