Patent ID: 6124277
Filing Date: 2000-09-26
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound having the formula ##STR35## wherein X is ##STR36## T is C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.8 alkyl, ##STR37## a is 0 or 1; Q is --OH, C.sub.1 -C.sub.4 alkoxy, or --NH--A;A is C.sub.1 -C.sub.4 alkyl, R""SO.sub.2 --, R""OC(O)--, R""C(O)--, HOOCSO.sub.2 --, HOOCC(O)--, or --(CH.sub.2).sub.g --COOH;g is 1, 2, or 3;R' is hydrogen or C.sub.1 -C.sub.4 alkyl;R"" is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 perfluoroalkyl, --(CH.sub.2).sub.d --COOH, or unsubstituted or substituted aryl, where aryl is phenyl, naphthyl, a 5- or 6-membered unsubstituted or substituted aromatic heterocyclic ring, having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen, or a 9- or 10-membered unsubstituted or substituted fused bicyclic aromatic heterocyclic group having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen;d is 1, 2, or 3;Y is ##STR38## R is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or --(CH.sub.2).sub.p --L--(CH.sub.2).sub.q --T'; where p is 0, 1, 2, 3, or 4, L is a bond, --O--, --S--, or --NH--, q is 0, 1, 2 or 3, and T' is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.8 cycloalkyl, --COOH, --CONH.sub.2, or Ar, where Ar is unsubstituted or substituted aryl as defined above for R""; andZ is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, halo, or R.sub.a SO.sub.2 NH--, where R.sub.a is C.sub.1 -C.sub.4 alkyl;provided that R is not hydrogen or C.sub.1 -C.sub.6 alkyl;and pharmaceutically acceptable salts and solvates thereof.