Patent ID: 6284197
Filing Date: 2001-09-04
Classification: B82Y,G01N,G02F,Y10S

Abstract:
A method of visually detecting an analyte-recognition moiety complex formed by an interaction between an analyte and a recognition moiety for said analyte by transducing said interaction to an organic mesogenic layer, said method comprising:(a) interacting said analyte with a surface comprising said recognition moiety, thereby forming an analyte-recognition moiety complex, said surface comprising:(i) a substrate;(ii) a self-assembled organosulfur or oganosilane monolayer bound to substrate; and(iii) said recognition moiety bound to said self-assembled monolayer;(b) contacting said analyte-recognition moiety complex with said organic mesogenic layer, thereby anchoring said organic mesogenic layer onto said self-assembled monolayer and causing at least a portion of a plurality of mesogens proximate to said recognition moiety to detectably switch from a first orientation to a second orientation, thereby transducing said interaction to said mesogenic layer, said transducing causing said mesogenic layer to register a visually detectable feature; and(c) visually detecting said feature.