Patent ID: 6228871
Filing Date: 2001-05-08
Classification: C07D

Abstract:
A compound in accordance with formula I: ##STR27##or a pharmaceutically acceptable salt or hydrate thereof,whereinX is O or S;R is H, C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl, aryl, halo, CF.sub.3, C.sub.3-10 heterocyclyl, or C.sub.5-10 heteroaryl, said alkyl, aryl, heteroaryl and heterocyclyl being optionally substituted with one to three members selected from R.sub.a ;R.sup.2 is H, C.sub.1-6 alkyl, aryl, C.sub.5-10 heteroaryl, C.sub.3-6 cycloalkyl, said alkyl, aryl, heteroaryl or cycloalkyl being optionally substituted with one to three members selected from R.sup.aR.sup.3 is C.sub.5-10 heteroaryl, optionally substituted with one to three members selected from R.sup.a ;R.sup.4 is aryl or C.sub.3-10 heterocyclyl, said aryl and heterocyclyl is optionally substituted with one to three members selected from R.sup.a ;R.sup.a is H, C.sub.1-10 alkyl, halogen, CF.sub.3, NO.sub.2, NHC(O)R*, OR, NR.sub.7 R.sub.8, aryl, C.sub.5-10 aralkyl, C.sub.5-10 heteroaryl or C.sub.3-10 heterocyclyl, said aralkyl, aryl and heteroaryl optionally substituted with one or two groups selected from NO.sub.2, halo, aryl, C.sub.1-6 -alkoxy, C.sub.1-6 alkyl, and CF.sub.3 ;R* is H, or C.sub.1-6 alkyl, NHC(O)CHR(C.sub.5-10 aralkyl), wherein the aryl ring of the aralkyl may be optionally substituted with one, two or three groups selected from OH, C.sub.1-6 alkyl, and halo;R is H or C.sub.1-6 alkyl; andR.sub.7 and R.sub.8 are independently selected from:H, C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl, COR, COOR, aryl, C.sub.3-10 heterocyclyl, or C.sub.5-10 heteroaryl or NR.sub.7 R.sub.8 can be taken together to form a heterocyclic 5-10 membered saturated or unsaturated ring containing, in addition to the nitrogen atom, one to two additional heteroatoms selected from the group consisting of N, O and S.