Patent ID: 6428815
Filing Date: 2002-08-06
Classification: A61K,Y10S,Y10T

Abstract:
A method for preparing a composition for the sustained release of biologically active protein comprising the steps of:a) atomizing using multifluid atomization a dispersed system comprising at least one biologically active protein and at least one solvent at a mass flow ratio of about 0.30 or greater to produce droplets; b) freezing the droplets to produce frozen droplets; c) removing the solvent from the frozen droplets to produce friable microstructures; d) dispersing the friable microstructures in at least one non-solvent for the biologically active protein; e) fragmenting the dispersed friable microstructures to produce submicron particles of the biologically active protein; f) providing a suspension comprising the submicron particles of the biologically active protein, at least one biocompatible polymer and at least one polymer solvent; and g) removing the polymer solvent to form a solid polymer/protein matrix.