Patent ID: 8865667
Filing Date: 2014-10-21
Classification: A61K,B82Y,C12N,G06N

Abstract:
1. A signal processing device for modulating the expression of a gene product depending on the presence or absence of ligands, the device comprising an RNA comprising: (1) a coding sequence for the gene product; (2) two or more aptamer-regulated polynucleotides, each said aptamer-regulated polynucleotides comprising at least one aptamer domain and an actuator domain, wherein each of said aptamer domain binds one ligand, and each of said actuator domain(s) has a functional activity that affects the expression of the gene product, wherein at least one of said aptamer-regulated polynucleotides further comprises: (3) an information transmission domain not overlapping with said actuator domain, said information transmission domain comprising: wherein binding of said aptamer domains by their respective ligands favors a conformation change in the actuator domain through a strand-displacement mechanism; and, wherein said conformation change modulates said functional activity, thereby affecting the expression of the gene product.