Patent ID: 8247593
Filing Date: 2012-08-21
Classification: C07C

Abstract:
1. A process of preparing a substituted 7-cyano quinone methide of formula wherein R i) reacting a substituted phenol of formula with paraformaldehyde and aqueous hydrochloric acid to form a substituted 4-chloromethylphenol of formula; ii) reacting the substituted 4-chloromethylphenol prepared in step i) with a cyanide salt in the presence of a catalyst to form a substituted 4-cyanomethylphenol of formula iii) reacting the substituted 4-cyanomethylphenol prepared in step ii) with a water-soluble iron cyanide salt, a water-soluble persulfate salt and base to form the substituted 7-cyano quinone methide, wherein steps i)-iii) are carried out in a single reaction vessel in a solvent system comprising water and one or more organic solvents and wherein after steps i) and ii) the aqueous portion of the reaction mixture is removed and the reagents for the subsequent step are added in aqueous solution or water and the reagents are added separately.