Patent ID: 6277838
Filing Date: 2001-08-21
Classification: A61K,C07J,Y10S

Abstract:
A method of treating or preventing stress or anxiety, treating or preventing mood disorders, alleviating or preventing seizure activity, insomnia, premenstrual syndrome or postnatal depression, or inducing anesthesia, comprising administering to said animal subject in need of such treatment an effective amount of a compound of Formula I: ##STR2##wherein:R is hydrogen, halogen, lower alkoxy, alkyl, optionally substituted 1-alkynyl or substituted alkyl;R.sub.1 is hydrogen, alkyl, alkenyl, aryl, aralkyl, alkynyl, optionally substituted aralkynyl, alkoxyalkyl, aminoalkyl, cyano, cyanoalkyl, thiocyanoalkyl, azidoalkyl, a substituted aralkynyl, arylalkyl, arylalkenyl, aryl, optionally substituted aralkylalkynyl, alkanoyloxyalkynyl, optionally substituted heteroaryloxyalkynyl, oxoalkynyl or a ketal thereof, cyanoalkynyl, optionally substituted heteroarylalkynyl, hydroxyalkynyl, alkoxyalkynyl, aminoalkynyl, acylaminoalkynyl, mercaptoalkynyl, hydroxyalkynyl dioic acid hemi-ester or a salt thereof, or alkynyloxyalkynyl;R.sub.2 is hydrogen, hydroxy, alkoxy, alkanoyloxy, carbalkoxyl, a keto group or amino group;R.sub.3 is an optionally substituted heteroarylacetyl group;R.sub.4 is hydrogen or methyl,R.sub.5 is hydrogen;R.sub.6 is hydrogen, alkanoyl, aminocarbonyl or alkoxycarbonyl;R.sub.7 is hydrogen, halogen, hydroxy, alkoxy, alkanoyloxy, carbalkoxyl, a methylene group (together with R.sub.3), or an alkoxymethylene group (together with R.sub.3);R.sub.8 is hydrogen or halogen;R.sub.9 is hydrogen, halogen, alkyl, alkoxy, arylalkoxy or amino; andR.sub.10 is hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, alkanoyloxy, carbalkoxyl, cyano, thiocyano or mercapto;or a physiologically acceptable 3-ester, 20-ester, 21-ester, 3,20-diester, or 3,21-diester thereof.