Patent ID: 6103216
Filing Date: 2000-08-15
Classification: A61K,Y10S

Abstract:
A heat stable oil-in-water emulsion comprising:a) up to 50% (w/v) of a lipophilic or amphipathic diagnostic, therapeutic, or biologically active agent which is a polyhalogenated triglyceride wherein at least one of the halogens of the polyhalogenated triglyceride is radioactive, and optionally a pharmaceutically acceptable fat or oil of natural, synthetic, or semi-synthetic origin which is a pharmacologically inert nonpolar lipid;b) up to 10% (w/v) phospholipid emulsifier;c) up to 5% (w/v) cholesterol, the amount of cholesterol being sufficient to facilitate apoprotein E association;d) up to 5% (w/v) of an osmolality adjusting agent; ande) the remainder of the emulsion being sterile water, the emulsion having a mean particle diameter of the oil phase between 50 to 200 nm with greater than 98% of the particles being less than 300 nm, and being substantially liposome-free and able to withstand heat sterilization without a significant change in mean particle size distribution and without losing its ability to associate with apoprotein E so as to be hepatocyte-selective.