Patent ID: 6060040
Filing Date: 2000-05-09
Classification: A61K,C07C,C07D,C08F,Y10S

Abstract:
A method of MR imaging a patient's gastrointestinal tract or a portion thereof comprising:(a) administering to the patient to be imaged an imaging amount of a compound of an acrylic chelatant compound of the formula(R.sup.1 R.sup.2)C--CR.sup.3 --CO--Z--A (1)and/orC(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--A--Z--CO--CR.sup.3 .dbd.C(R.sup.1 R.sup.2) (2)in monomer, oligomer, homopolymer or copolymer form, in which R.sup.1, R.sup.2 and R.sup.3 represent H or a saturated or unsaturated C.sub.1-10 aliphatic radical optionally substituted by one or more OH groups; Z is a covalent bond or a spacer linker and A is a linear chelant moiety capable of complexing a paramagnetic metal by chelation, and thereafter(b) MR imaging the patient.