Patent ID: 8076454
Filing Date: 2011-12-13
Classification: A61K,C07D,C07H,C07K,C12N,Y10S

Abstract:
1. An isolated polypeptide encoded by a polynucleotide encoding a Group H nuclear receptor ligand binding domain comprising a mutation at a) amino acid residue 132 of SEQ ID NO: 1, b) both of amino acid residues 96 and 119 of SEQ ID NO: 1, c) both of amino acid residues 110 and 128 of SEQ ID NO: 1, d) both of amino acid residues 52 and 110 of SEQ ID NO: 1, e) both of amino acid residues 125 and 132 of SEQ ID NO: 1, f) all three of amino acid residues 107, 110, and 127 of SEQ ID NO: 1, g) all three of amino acid residues 52, 107 and 127 of SEQ ID NO: 1 h) all three of amino acid residues 107, 127 and 259 of SEQ ID NO: 1, or i) at least one of F48Y, F48W, F48L, F48N, F48R, F48K, I51M, I51N, I51L, T52M, T52E, T52P, T52R, T52W, T52G, T52Q, M54W, M54T, M92L, M92E, R95H, R95M, R95W, V96L, V96W, V96S, V96E, F109W, F109P, F109L, F109M, F109N, A110E, A110N, A110W, N119F, Y120W, Y120M, M125P, M125R, M125E, M125L, M125C, M125W, M125G, M125I, M125N, M125S, M125V, V128F, M219K, M219W, M219Y, M219A, L223K, L223R, L223Y, L234M, L234I, L234R, L234W, W238P, W238E, W238Y, W238M, W238L.