Patent ID: 8383136
Filing Date: 2013-02-26
Classification: A61K,A61P,B82Y,Y02A,Y10S

Abstract:
1. A composition comprising micelles encapsulating three drugs, wherein the three drugs are non-covalently encapsulated in the interior of the micelles; the micelles comprise poly(ethylene glycol)-block-poly(lactic acid) polymers where the hydrophobic poly(lactic acid) block of the polymers orient toward the interior of each micelle, and the hydrophilic poly(ethylene glycol) block of the polymers orient toward the exterior of each micelle; a first drug of the three drugs encapsulated in the micelles is 17-AAG; a second drug of the three drugs encapsulated in the micelles is paclitaxel or docetaxel; a third drug of the three drugs encapsulated in the micelles is rapamycin, deforolimus, temsirolimus, everolimus, etoposide, or teniposide; the drug loading of the micelles is about 1 wt. % to about 50 wt. % with respect to the mass of the micelles; and the composition is substantially free of ethanol, dimethyl sulfoxide, castor oil, and castor oil derivatives.