Patent ID: 8927605
Filing Date: 2015-01-06
Classification: A23G,A23L,A23V,A24B,A24D,A61K,A61P,A61Q,C07C,C07D,C09D,D06M

Abstract:
1. A method for in-vitro or in-vivo modulation of the cold-menthol receptor TRPM8, wherein the receptor is brought into contact with one or more compounds of formula (III) in which R H; halogen; linear or branched C linear or branched C mono- or polynuclear aryl-, arylalkyl- and heteroaryl groups, which optionally carry 1, 2, 3 or 4 identical or different substituents selected from the group consisting of NH two adjacent radicals R R linear or branched C mono- or polynuclear aryl-, arylalkyl-, aryloxy-, heteroaryl- and heteroaryloxy groups, which optionally carry 1, 2, 3 or 4 identical or different substituents selected from the group consisting of NH C X is —C and salts of these compounds; optionally in pure stereoisomer form or as a mixture of stereoisomers, provided that the compound of formula (III) is not: