Patent ID: 7626015
Filing Date: 2009-12-01
Classification: A61P,C12N

Abstract:
1. A compound having the structure: wherein alternating ribonucleotides in the antisense and the sense strands are modified to result in a 2′-O-methyl modification in the sugar residue of the ribonucleotides; wherein the ribonucleotides at the 5′ and 3′ termini of the antisense strand are modified to result in the 2′-O-methyl modification; wherein the ribonucleotides at the 5′ and 3′ termini of the sense strand are unmodified; wherein the antisense and the sense strands are non-phosphorylated at the 3′ and 5′ termini; and wherein the compound is between 19-23 nucleotides in length.