Patent ID: 6118001
Filing Date: 2000-09-12
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I)B--X--(CH.sub.2).sub.n --CHR.sup.1 --(CH.sub.2).sub.m --COY (I)wherein m and n are each independently 0 or 1, but are not both 0;X is S(O).sub.0-2 ;Y is selected from the group consisting of OR.sup.2 and NHOH;R.sup.1 is H or is a group selected from the group consisting of H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, heterocycloalkyl, C.sub.1-6 alkyl-heterocycloalkyl, cycloalkyl, and C.sub.1-6 alkyl-cycloalkyl, and said group is optionally substituted with R.sup.9 ;R.sup.2 is selected from the group consisting of h and C.sub.1-6 alkyl;B is selected from the group consisting of heterocycloalkenyl and heterocycloalkyl optionally substituted by a substituent selected from the group consisting of R.sup.5, C.sub.1-6 alkyl-R.sup.5, C.sub.3-6 alkenyl-R.sup.7, aryl optionally substituted with R.sup.5, aryl-C.sub.1-6 alkyl-R.sup.5, C.sub.1-6 alkyl-aryl optionally substituted with R.sup.5, C.sub.1-6 alkyl-heteroaryl optionally substituted with R.sup.5, aryl-C.sub.2-6 alkenyl-R.sup.5, heteroaryl optionally substituted with R.sup.5, heteroaryl-C.sub.1-6 alkyl-R.sup.5, cycloalkyl optionally substituted with R.sup.5, benzofused cycloalkyl optionally substituted with R.sup.5, heterocycloalkyl optionally substituted with R.sup.5, benzofused heterocycloalkyl optionally substituted with R.sup.5, and the groups: ##STR6## R.sup.5 is selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl-R.sup.7, halogen, CN, NO.sub.2, N(R.sup.6).sub.2, OR.sup.6, COR.sup.6, CO.sub.2 R.sup.2, CON(R.sup.6).sub.2, NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.8, and SO.sub.2 N(R.sup.6).sub.2 ;R.sup.6 is H or a group selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteraryl, C.sub.1-6 alkyl-heteroaryl, cycloalkyl, C.sub.1-6 alkyl-cycloalkyl, heterocycloalkyl, and C.sub.1-6 alkyl-heterocycloaklyl, wherein said group is optionally substituted with a substituent selected from the group consisting of R.sup.8, COR.sup.8, SO.sub.0-2 R.sup.8, CO.sub.2 R.sup.8, OR.sup.8, CONR.sup.2 R.sup.8, NR.sup.2 R.sup.8, halogen, CN, SO.sub.2 NR.sup.3 R.sup.8, and NO.sub.2, and for each case of N(R.sup.6).sub.2 the R.sup.6 groups are the same or different or N(R.sup.6).sub.2 is heterocycloalkyl optionally substituted with a substituent selected from the group consisting of R.sup.8, COR.sup.8, SO.sub.0-3 R.sup.8, OR.sup.8, CONR.sup.2 R.sup.8, NR.sup.2 R.sup.8, halogen, CN, SO.sub.2 NR.sup.2 R.sup.8, and NO.sub.2 ;R.sup.7 is selected from the group consisting of COR.sup.6, CON(R.sup.6).sub.2, CO.sub.2 R.sup.8, and SO.sub.2 R.sup.8 ;R.sup.8 is selected from the group consisting of C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl, and C.sub.1-6 alkyl-heteroaryl; andR.sup.9 is selected from the group consisting of OR.sup.6, COR.sup.6, CO.sub.2 R.sup.3, CON(R.sup.6).sub.2, NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.8, SO.sub.2 N(R.sup.6).sub.2, phthalimido, succinimido, and the group ##STR7## or a salt, solvate, hydrate, or protected amino or protected carboxy derivative thereof.