Patent ID: 8236761
Filing Date: 2012-08-07
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for treating obesity or solid tumors associated with obesity, comprising administering to a subject in need thereof a composition that comprises an isolated angiotensin-like factor that is a hepatocyte growth factor (HGF) hinge region mimic, under conditions and for a time sufficient for the angiotensin-like factor to interact with one or both of i) a cell surface c-Met receptor on a preadipocyte or adipocyte and ii) a native HGF hinge region polypeptide in the subject, wherein the angiotensin-like factor is capable of specifically binding to one or both of the cell surface c-Met receptor and the native HGF hinge region polypeptide, thereby treating obesity or the solid tumors associated with obesity, wherein said angiotensin-like factor is a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8 or 7 amino acids that comprises Lys-Asp-Tyr-Ile-Arg-Asn-Cys [SEQ ID NO:82]; or a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7 or 6 amino acids that comprises Lys-Asp-Tyr-Ile-Arg-Asn (SEQ ID NO: 93).