Patent ID: 8513283
Filing Date: 2013-08-20
Classification: A61P,C07D

Abstract:
1. A method of treating cancer in a subject, said method comprising administering an effective amount of a compound of formula I to a patient in need of such treatment wherein R is A is selected from direct bond or —N(R′)—; B is selected from direct bond, O, —N(R′)—, —C(═X)— —C(═X)N(R′)—, lower alkylenyl-C(═X)— or lower alkylenyl-C(═X)N(R′)—; X is selected from O or S; R′ is selected from H, halogen, halogeno-lower alkyl, lower alkyl, hydroxy, lower alkoxy, lower alkoxyalkoxy, lower alkenyl, lower alkynyl, amino, alkylamino, alkoxyamino, cycloalkyl, cycloalkenyl, aryl, lower aryl, heterocyclyl or lower heterocyclyl; R R R W and Z are each independently selected from O, S, N—R or CH—R; G is selected from C—R, C—(CN) or N; a and c are each independently selected from 0, 1, 2, 3 or 4; b is selected from 1, 2, 3, 4 or 5; and or a pharmaceutically acceptable salt thereof.