Patent ID: 8999001
Filing Date: 2015-04-07
Classification: A61L

Abstract:
1. A biocompatible implant for repair of a bone defect which comprises: (a) a flexible membrane comprising a biocompatible material having an inner and an outer surface capable of being fitted around said bone defect to create an enclosed void space, said membrane being seeded with autologous cells on one or both surfaces; and (b) a platelet-rich plasma gel composition capable of being injected through the membrane using a syringe within said void space created by the membrane and into contact with the inner surface of the membrane, wherein said platelet-rich plasma gel composition further comprises autologous cells of one type or a mixture of at least two types, and wherein when injected, the platelet-rich plasma gel composition is in contact with the inner surface of the flexible membrane, wherein said platelet-rich plasma gel composition further comprises a nanoparticulate mineral selected from the group consisting of hydroxyapatite, coralline hydroxyapatite, hydroxyapatite carbonate, bioactive glasses and ceramic, calcium phosphate ceramic, calcined bone, tricalcium phosphate, wherein the nanoparticulate mineral has an average particle diameter of 1 nm to 5 μm, and wherein the nanoparticulate mineral constitutes 0.01% to 60% by volume of the platelet-rich plasma gel composition.