Patent ID: 7465807
Filing Date: 2008-12-16
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (I): wherein: R Ph is phenyl optionally substituted from 1 to 3 times with a substituent selected from the group consisting of halo, alkyl, —OH, —R Het is a 5-7 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from N, O and S, or a 5-6 membered heteroaryl having 1, 2, 3 or 4 heteroatoms selected from N, O and S, each optionally substituted from 1 to 2 times with a substituent selected from the group consisting of halo, alkyl, oxo, —OH, —R Q a, b and c are the same or different and are each independently 0 or 1 and at least one of a or b is 1; n is 0, 1, 2, 3 or 4; Q aa, bb and cc are the same or different and are each independently 0 or 1; each Y each R each R  wherein: wherein when Q wherein when Q R f is 0, 1 or 2; and each R or a pharmaceutically acceptable salt thereof; said process comprising the steps of reacting one equivalent of a compound of formula (III): or an acid addition salt thereof, with one equivalent of a compound of formula (IV): wherein R in the presence of a base additive selected from sodium bicarbonate, triethylamine, sodium acetate, N-methylimidazole, pyridine and N-methylbenzimidazole.