Patent ID: 7713946
Filing Date: 2010-05-11
Classification: A61K,A61P

Abstract:
1. A method of increasing insulin sensitivity in a mammal in need thereof, comprising administering to a mammal in need thereof a therapeutically effective dose of a compound of Formula I: wherein: R is hydrogen or lower alkyl; R R and YR R R R X and Y are independently a covalent bond or alkylene optionally substituted with 1 to 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, amino, aminocarbonyl, alkoxycarbonylamino, azido, cyano, halogen, hydroxy, keto, thiocarbonyl, carboxy, carboxyalkyl, arylthio, heteroarylthio, heterocyclylthio, thiol, alkylthio, aryl, aryloxy, heteroaryl, aminosulfonyl, aminocarbonylamino, heteroaryloxy, heterocyclyl, heterocyclooxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-aryl, —SO-heteroaryl, —SO with the proviso that when R 1 is methyl and Y is a covalent bond, R 3 cannot be phenyl when X is methylene or ethylene.