Patent ID: 6670473
Filing Date: 2003-12-30
Classification: A61P,C07D

Abstract:
A compound of formula (Vb): wherein B is a fused imidazolyl; and wherein: A is â€”R1, â€”OR1, â€”C(O)N(R1)R2, â€”P(O)[N(R1)R2]2, â€”N(R1)C(O)R2, â€”N(R16)C(O)OR2, â€”N(R1)R21, â€”N(R16)C(O)N(R1)R16, â€”S(O)tR1, â€”SO2NHC(O)R1, â€”N(R1)SO2R22, â€”SO2N(R1)H, â€”C(O)NHSO2R22, or â€”CH&boxH;NOR1; each X and Y are N; each W is N or CH; n is zero or an integer from 1 to 3; t is zero, one or two; â€ƒis an optionally substituted N-heterocyclyl; each R1 and R2 are independently chosen from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, â€”[C0-C8 alkyl]â€”R9, â€”[C2-C8 alkenyl]â€”R9, â€”[C2-C8 alkynyl]â€”R9, â€”[C2-C8 alkyl]â€”R10 (optionally substituted by hydroxy), â€”[C1-C8]â€”R11 (optionally substituted by hydroxy), and optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is an optionally substituted N-heterocyclyl; R9 is chosen from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently chosen from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, optionally substituted â€”S(O)tâ€”R22, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl)amino, hydroxy, mercapto, and alkylsulfonamido; each R11 is independently chosen from the group consisting of cyano, di(alkoxy)alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R14, and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, â€”C(O)R22 or â€”SO2R22; or R21 taken together with R1 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; or R21 taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and as a single stereoisomer or mixture thereof, or a pharmaceutically acceptable salt thereof.