Patent ID: 8633297
Filing Date: 2014-01-21
Classification: A61P,C07K,C12N,G01N

Abstract:
1. A recombinant polypeptide scaffold comprising: I. seven beta strand domains designated A, B, C, D, E, F, and G, having the amino acids of: II. linked to six loop regions such that a loop region connects each beta strand domain, is designated AB, BC, CD, DE, EF, and FG and corresponds to the cognate loop regions of SEQ ID NO:1, the cognate loop regions of SEQ ID NO: 1 consisting of residues: at least one of said loop regions being a non-naturally occurring variant of the cognate loop region in SEQ ID NO: 1; and III. a disulfide bond linking the F and G beta strand domains or linking the C and F beta strand domains, wherein said scaffold binds a target.