Patent ID: 6368572
Filing Date: 2002-04-09
Classification: A01K,G01N

Abstract:
A method for evaluating a bacterial exotoxin pathology in a mouse model, comprising:(a) providing a chimeric mouse M3 comprising a mouse M1 which is resistant to bacterial exotoxins, wherein said mouse M1 has been (i) treated to substantially destroy the hematopoietic cells of the mouse M1 such that the resulting treated M1 mouse could not survive under normal laboratory conditions, and then (ii) transplanted with hematopoietic cells from a mouse M2 having a severe combined immunodeficiency, thereby forming said chimeric mouse M3; (b) administering to said chimeric mouse M3 at least one bacterial exotoxin; and then (c) evaluating the physiological response of the toxin administered to said mouse M3 as a model of a bacterial exotoxin pathology.