Patent ID: 6048876
Filing Date: 2000-04-11
Classification: A61P,C07C,C07D

Abstract:
A pharmaceutical composition of matter for the alleviation or treatment of symptoms based on ischemic diseases or symptoms derived from seizures, epilepsy and migraine headaches comprising in an amount effective for alleviating or treating said symptoms a compound having the formula (I) or its pharmaceutically acceptable salt: ##STR138## wherein, Q represents a group having the formula:R--A--B--in which R represents a hydrogen atom, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenoxy group, or a substituted or unsubstituted benzoyl group,A represents a connecting bond, a cycloalkylene group, an alkenylene group which may be substituted by a lower alkyl group, a dialkoxymethylene group, or a hydroxyiminomethylene group, andB represents an alkylene group which may be substituted by a hydroxyl group or an alkoxy group;a group having the formula: ##STR139## in which R.sup.1 represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted by a halogen atom, an alkoxy group, or an hydroxyl group; ora group having the formula: ##STR140## in which R.sup.2 represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted by a halogen atom, an alkoxyl group, or a hydroxyl group;X represents an oxygen atom or a methylene group, the substitution of X for the benzene ring being in a para position,E and Y may be the same or different from each other and represent a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxy group, or an alkyl group which may be substituted by a halogen atom,wherein the dotted line shows the presence or absence of a bond, when said dotted line shows the presence of a bond, further wherein Z represents a carbon atom, and when said dotted line shows the absence of a bond, Z represents CH.