Patent ID: 7405194
Filing Date: 2008-07-29
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A method of treating a subject having melanoma, comprising administering to said subject an effective amount of a compound comprising the structure of Formula I, wherein A is a Met-AP2 inhibitory core; W is O or NR R X is alkylene or substituted alkylene; n is 0 or 1; R Z is —C(O)— or alkylene-C(O)—; and P is a peptide comprising from 1 to about 100 amino acid residues attached at its amino terminus to Z or a group OR Z is —O—, —NR P is hydrogen or a peptide consisting of from 1 to about 100 amino acid residues attached at its carboxy terminus to Z; and pharmaceutically acceptable salts thereof.