Patent ID: 6569886
Filing Date: 2003-05-27
Classification: A01N,A61P,C07D

Abstract:
A method of controlling parasites in or on an animal in need of same comprising administering to said animal a parasiticidally effective, substantially non-emetic amount of a compound of formula (II): wherein:R21 is cyano, C(&boxH;S)NH2, C(&boxH;NOH)NH2 or C(&boxH;NNH2NH2; R22 is S(O)mR23; R23 is alkyl or haloalkyl; R24 is OH, HC(O)Oâ€”, R26C(O)Oâ€”, R25OC(O)Oâ€”, R25R25Nâ€”C(O)â€”Oâ€” or R25S(O)nC(O)Oâ€”; R25 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, haloalkoxyalkyl, adamantyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, haloalkylaminoalkyl, di(haloalkyl)aminoalkyl, aryl optionally substituted, hetaryl optionally substituted, arylalkyl optionally substituted, hetarylalkyl optionally substituted, C2-C6 alkenyl or C2-C6 alkynyl; or two groups R25 form together with the nitrogen to which they are attached a 3 to 7 membered ring which optionally has one or more additional heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; X is selected from the group consisting of nitrogen and Câ€”R32; R31 and R32 are independently selected from the group consisting of halogen, hydrogen, CN, C1-C3 alkyl and NO2; R33 is selected from the group consisting of halogen, haloalkyl, haloalkoxy, â€”S(O)rCF3 and SF5, or R33 forms a ring together with R34; R34 is hydrogen or together with R33 forms a group OCF2O, CF2OCF2, CF2OCF2O or CF2CF2O, which group forms together with the carbons to which it is attached a five to six membered ring; m is selected from the group consisting of 0, 1 or 2; and r is selected from the group consisting of 0, 1 and 2; or a veterinarily acceptable salt thereof; provided that when R21 is cyano, then R24 is not R25R25â€”Nâ€”C(O)â€”Oâ€”.