Patent ID: 7601868
Filing Date: 2009-10-13
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound represented by the formula: wherein Ar a phenyl having a C R is (i) a hydrogen atom; (ii) an optionally halogenated C (iii) a phenyl; or (iv) a pyridyl, each of (iii) and (iv) optionally having 1 to 5 substituents selected from the following Group C: (a) a halogen atom, (b) a C (c) a nitro, (d) a cyano, (e) an optionally halogenated C (f) an optionally halogenated C (g) an optionally halogenated C (h) an optionally halogenated C (i) a hydroxy, (j) an amino, (k) a mono- or di-C (l) a formyl, (m) a carboxy, (n) a carbamoyl, (o) a thiocarbamoyl, (p) an optionally halogenated C (q) a C (r) a mono- or di-C (s) an optionally halogenated C (t) a formylamino, (u) an optionally halogenated C (v) a C (w) a C (x) a C (y) a C (z) a mono- or di-C (aa-1) phenyl, (aa-2) a 5- or 6-membered aromatic heterocyclic group, (aa-3) a 9- to 14-membered fused bi- or tri-cyclic aromatic hydrocarbon group, and (aa-4) a 9- to 14-membered fused bi- or tri-cyclic aromatic heterocyclic group, each of (aa-1 )-(aa-4) optionally having 1 to 5 substituents selected from the following Group B: a halogen atom a C a nitro, a cyano, an optionally halogenated C a hydroxy-C an optionally halogenated C an optionally halogenated C an optionally halogenated C a hydroxy, an amino, a mono- or di-C an amino-C a mono- or di-C a formyl, a carboxy, a carbamoyl, a thiocarbamoyl, an optionally halogenated C a C a 5- or 6-membered heterocyclylcarbonyl, a mono- or di-C a 5- or 6-membered heterocyclylcarbamoyl, a carbamoyl-C a mono- or di-C a 5- or 6-membered heterocyclylcarbonyl-C a 5- or 6-membered heterocyclylcarbamoyl-C an optionally halogenated C a formylamino, an optionally halogenated C a C a C a C a C a mono- or di-C a mono- or di-C a 5- or 6-membered non-aromatic heterocyclic group; Ra (i) a hydrogen atom, (ii) an optionally halogenated C (iii) a phenyl, (vi) a halogen atom, (v) a pyridyl, (vi) a cyano, (vii) an optionally halogenated C (viii) an optionally halogenated C (ix) an amino, (x) a mono- or di-C (xi) a formyl, (xii) an optionally halogenated C (xiii) an optionally halogenated C each of (iii) and (v) optionally having 1 to 5 substituents selected from the above-mentioned Group C; Ar is (i) benzene, or (ii) a 5- or 6-membered aromatic heterocycle, each of (i) and (ii) optionally having 1 to 4 substituents selected from the above-mentioned Group B; Y is an optionally halogenated alkylene group; and R (1) the same or different and each is a hydrogen atom or a C (2) R (a) the above-mentioned Group B, (b) a C (c-1) phenyl, (c-2) a 5- or 6-membered aromatic heterocyclic group, (c-3) a 9- to 14-membered fused bi- or tri-cyclic aromatic hydrocarbon group, and (c-4) a 9- to 14-membered fused bi- or tri-cyclic aromatic heterocyclic group, each of (b) and (c-1)-(c-4) optionally having 1 to 5 substituents selected from the above-mentioned Group B, or (3) R or a salt thereof.