Patent ID: 8889709
Filing Date: 2014-11-18
Classification: A61P,C07D,C12N

Abstract:
1. A method of treatment of an inflammatory disease or condition comprising administering a therapeutically effective amount of an isoQC inhibitor to a subject in need thereof wherein: (a) the inflammatory disease or condition is associated with a pyroglutamated peptide; (b) the inflammatory disease or condition is selected from the group consisting of rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis, and osteoporosis; (c) the isoQC inhibitor comprises a compound of formula (I): or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof; (d) R (e) R (f) R (g) X represents O or S; and (h) Y represents O or S.