Patent ID: 7323575
Filing Date: 2008-01-29
Classification: C07B,C07D

Abstract:
1. A process for the synthesis of perindopril or pharmaceutically acceptable salts thereof, starting from a compound of formula (I): wherein the compound of formula (I) is obtained via reaction of racemic indoline-2-caroboxylic acid of formula (III): with a chiral amine to yield a salt of formula (IV): which is filtered off, to yield: after having carried out between 2 and 6 cycles of the above-described series of operations, all the portions made up of the compound of formula (I) are combined, which compound of formula (I) is subjected to catalytic hydrogenation followed by a coupling reaction with a compound of formula (IV): to yield perindopril, wherein the perindopril is converted, if desired, to a pharmaceutically acceptable salt.