Patent ID: 6596754
Filing Date: 2003-07-22
Classification: A61K,A61P,C07D,Y02A

Abstract:
A method for the treatment of a syndrome caused by the aggravation of sepsis, comprising administering an effective amount of a compound of formula (1) or a salt or solvate of a compound of formula (1) to a subject in need thereof,wherein formula (1) is: â€ƒwherein R1 represents a hydrogen atom or a lower alkoxy group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a carboxyl group, an alkoxycarbonyl group, a carboxyalkyl group, or an alkoxycarbonylalkyl group; R3 represents a hydrogen atom, a carboxyl group, an alkoxycarbonyl group, a carboxyalkyl group, an alkoxycarbonylalkyl group, a carboxyalkoxyl group or an alkoxycarbonylalkoxyl group; R4 represents a hydrogen atom, a halogen atom, an amino group, a cyano group, a nitro group, a hydroxyl group, a lower alkyl group, or a lower alkoxyl group; n represents a number between 0 and 4 inclusive; and A represents: a C1-C4 alkylene group optionally substituted by one or two hydroxyalkyl group(s), carboxyl group(s), alkoxycarbonyl group(s), carboxyalkyl group(s), or alkoxycarbonylalkyl group(s), a group represented by the following formula: â€ƒwherein E represents a lower alkylene group or a carbonyl group and R5 represents a hydrogen atom or a group represented by formula â€”Dâ€”Wâ€”R6, wherein D is a group represented by and Z is an oxygen atom or a sulfur atom, a group represented by â€ƒor a sulfonyl group; â€ƒwherein W represents a single bond or a group represented by â€”NR7â€”, wherein R7 represents a hydrogen atom, a carbamoyl group, a lower alkoxycarbonyl group, a mono- or di-lower alkylaminocarbonyl group, a lower alkylsulfonyl group, a mono- or di-lower alkylaminothiocarbonyl group, a lower alkyl group which may have a substituent, or a lower alkanoyl group which may have a substituent; and â€ƒwherein R6 represents a hydroxyl group, a lower alkoxyl group, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or a heteroaryl group which may have a substituent; X represents a single bond, an oxygen atom, a sulfur atom, or a carbonyl group; Y represents a saturated or unsaturated 5- or 6-membered heterocyclic or cyclic hydrocarbon group which may have a substituent, an amino group which may have a substituent, or an aminoalkyl group which may have a substituent; and is selected from the group consisting of indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl, and indanyl.