Patent ID: 7022313
Filing Date: 2006-04-04
Classification: A61K

Abstract:
1. A method for making a powdered pharmaceutical composition, said method comprising: (a) providing a mixture of pre-formed hydrogel particles; (b) contacting the hydrogel particles with an aqueous composition containing at least one pharmacologically active agent for a period sufficient to allow the agent to associate with the hydrogel particles and be incorporated therewith; (c) separating the hydrogel particles from the aqueous composition in at least a partial drying step to obtain primary loaded hydrogel particles having the active agent incorporated therewith; (d) contacting the primary loaded hydrogel particles with an aqueous composition containing said pharmacologically active agent for a period sufficient to allow further agent to associate with the hydrogel particles and be incorporated therewith; (e) separating the hydrogel particles formed in step (d) from the aqueous composition in at least a partial drying step to obtain secondary loaded hydrogel particles having the active agent incorporated therewith; and (f) drying the secondary loaded hydrogel particles to obtain a powdered pharmaceutical composition.