Patent ID: 8805620
Filing Date: 2014-08-12
Classification: C12Q,G16B,G16H,Y02A

Abstract:
1. A method of selecting a donor or reproductive partner for a potential parent from a pool of sperm donors, or from a pool of oocyte donors or from a pool of potential reproductive partners, the method implemented by a computer processor executing program instructions, the method comprising the steps of: (a) using the processor, generating a recipient haplopath H (b) using the processor, generating a donor haplopath H (c) using the processor, combining said recipient haplopath H including two alleles h x recipient and h x donor of a genotype at each of the plurality of loci x=1, . . . , N for a potential progeny; (d) using the processor, comparing genotypes of said virtual progeny genome sampling to one or more databases of genotype-phenotype associations to determine a likelihood of expression of one or more phenotypes for the potential progeny having said virtual progeny genome sampling; and (e) repeating steps (a)-(d) for a plurality of recipient and donor haplopaths from, respectively, the recipient and donor potential parents i=1, . . . ,p to generate a virtual progeny genome G (f) generating probabilities or probability distributions for said potential progeny expressing said one or more phenotypes based on the likelihoods determined for the plurality of virtual progeny genome samplings in the virtual progeny genome G (g) repeating steps (a)-(f) for each member of said pool of sperm donors, oocyte donors or potential reproductive partners.