Patent ID: 6110928
Filing Date: 2000-08-29
Classification: A61K,A61P,C07D

Abstract:
A method of treating an endoparasitic infection in a mammal afflicted therewith comprising administering to said mammal a composition containing 4a, 5a, 8a, 8b-tetrahydro-6H-pyrrolo[3',4',4,5] furo[3,2-b]pyridine-6,8(7H)-dione derived from the general formula (I) and salts thereof, ##STR234## in which R.sup.1 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, arylalkyl, aryl, which are optionally substituted,R.sup.2 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, alkoxylcarbonyl, which are optionally substituted,R.sup.3 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, alkoxycarbonyl, which are optionally substituted,R.sup.4 represents hydrogen, straight-chain or branched alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, amino, alkylamino, dialkylamino, cycloalkylamino, which are optionally substituted,R.sup.5 represents hydrogen, straight-chain or branched alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, which are optionally substituted, formyl, alkoxydicarbonyl or optionally represents a radical from the group consisting of G.sup.1, G.sup.2, G.sup.3 and G.sup.4 ##STR235## in which R.sup.6 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, aryl, arylalkyl, which are optionally substituted,R.sup.7 and R.sup.8 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, cycloalkyl, cyloalkylalkyl, aryl, arylalkyl, which are optionally substituted, orR.sup.7 and R.sup.8 together represent a spirocyclic ring which is optionally substituted, ##STR236## can denote carboxyl; thiocarboxyl, --C.dbd.CH--NO.sub.2, --C.dbd.CH--CN, --C.dbd.N--R.sup.9, sulfoxyl, sulfonyl, --P(O)--OR.sup.10 or P(S)--OR.sup.10,R.sup.9 represents hydrogen, hydroxyl, alkoxy, alkylcarbonyl, halogenoalkylcarbonyl, alkylsulfonyl, nitro or cyano, andR.sup.10 represents hydrogen or alkyl, andQ represents straight-chain or branched alkyl, alkenyl, alkinyl, cycloalkyl, aryl, arylalkyl, which are optionally substituted, or optionally represents a radical from the group consisting of G.sup.5 and G.sup.6 ##STR237## in which ##STR238## can denote carboxyl, thiocarboxyl or sulfonyl, Y represents oxygen, sulfur or --NR.sup.12,R.sup.11 in the case where Y represents nitrogen, can denote a cyclic amino group linked via a nitrogen atom,R.sup.11 and R.sup.12 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, which are optionally substituted,R.sup.13 represents hydrogen or alkyl,R.sup.14 represents hydrogen, straight-chain or branched alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, alkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cyano, aryl, arylalkyl, stand which are optionally substituted, andoptical isomers or racemates thereof.