Patent ID: 8664233
Filing Date: 2014-03-04
Classification: A61P,C07D

Abstract:
1. A substituted 5H-pyramido[5,4-B]indole selected from the group consisting of: 7-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-9-ol 4-ethoxy-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indol-9-ol 4-ethoxy-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-9-ol 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole-4,9-diol 4-ethoxy-8-(3,4,5-trimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 1-(7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-4-yl)piperidin-4-ol 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-4-ol 4-((pyridin-2-yl)methoxy)-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-((pyridin-4-yl)methoxy)-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-((pyridin-3-yl)methoxy)-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-methylthio-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 2-(7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-4-ylamino)ethanol 7-bromo-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-4-ol 4-(2-morpholinoethoxy)-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-4-morpholino-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-thiomorpholino-5H-pyrimido[5,4-b]indole 4-morpholino-2-(piperazin-1-yl)-7-(pyrindin-4-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-N-(2-morpholinoethyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole-4-amine 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-piperidino-5H-pyrimido[5,4-b]indole 4-cyclopropylmethoxy-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-(1H-imidazol-1-yl)-7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(piperidin-4-yloxy)-5H-pyrimido[5,4-b]indole 4-cyclopropylmethoxy-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-morpholino-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)benzoic acid ethyl ester 4-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)benzoic acid hydrochloride 4-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)phenol hydrochloride 3-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)benzoic acid methyl ester 3-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)benzoic acid hydrochloride 4-ethoxy-7-(furan-2-yl)-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole tert-butyl-2-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)-1H-pyrrole-1-carboxylate tert-butyl-4-(4-ethoxy-7-(pyridin-3-yl)-5H-pyrimido[5,4-b]indol-2-yl)-piperazine-1-carboxylate 7-(benzo[d][1,3]dioxol-5-yl)-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-N-(thiazol-2-yl)-5H-pyrimido[5,4-b]indole-4-amine 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(1H-pyrrol-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(1H-pyrazol-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(1H-1,2,3-triazol-1-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(4H-1,2,4-triazol-4-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(piperazin-1-yl)-4-(pyrrolidin-1-yl)-5H-pyrimido[5,4-b]indole (4-(4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)piperazin-1-yl)(phenyl)methanone 4-ethoxy-2-(piperazin-1-yl)-7-(4-(pyrimidin-2-yl)piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperidin-4-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-7-(3,4-dimethoxyphenyl)-2-(piperidin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-7-(3,4-dimethoxyphenyl)-2-(piperidin-3-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-7-(3,4-dimethoxyphenyl)-2-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 7-(3,4-dimethoxyphenyl)-2-(pyridin-4-yl)-5H-pyrimido[5,4-b]indol-4-ol N,N-di-(2-hydroxyethyl)-4-ethoxy-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole-2-amine 2-(4-ethoxy-9-methoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indol-7-yl)benzeneamine 2-{2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indol-4-yloxy}ethanol 2-ethoxy-4-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(4-methylpiperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-6-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-7-(2-aminopyridin-5-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-7-(3,4-dimethoxy-phenyl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-7-(pyridin-3-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-2-(piperazin-1-yl)-8-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-7-morpholino-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole 4-ethoxy-9-methoxy-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole.