Patent ID: 8648041
Filing Date: 2014-02-11
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), wherein the first K residue is designated K 37 , and the second K residue is designated K 26 , which analogue has a maximum of three amino acid modifications as compared to GLP-1(7-37), where two of the modifications are K 37 and a Q or an R at a position corresponding to position 34 of GLP-1(7-37); which derivative comprises an albumin binding moiety attached to each of K in which y is an integer in the range of 7-15; or a pharmaceutically acceptable salt, amide, or ester thereof.