Patent ID: 8163736
Filing Date: 2012-04-24
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein and when R1, R2, R1′, R2′ are the same or different and independently chosen from halide and alkyl optionally substituted by one or more Hal, CN, NRR′, CF B and B′ are the same or different and independently represent alkenyl being optionally substituted by one or more Hal, CN, R, CF X and X′ are the same or different and independently chosen from one or more —O—, —NR—, —(C═O)—, and —S(O) A and A′ are the same or different and independently represent alkyl or alkenyl optionally containing an oxygen, a nitrogen or a sulfur atom and each being optionally substituted by one or more Hal, CN, NRR′, CF Y and Y′ are the same or different and independently chosen from H and OR; T is —NR—, or a 4 to 10-membered aryl, cycloalkyl, heterocyclic or heteroaryl, each being optionally substituted by one or more Hal, CN, NRR′, CF wherein G is a single or double bond, —O—, —S—or —NR—; D is a single bond or -E-, -E-NR—, -E-NR—F—, -E-O—, -E-O—F—, -E-NR—CO—, -E-NR—CO—F—, -E-CO—, —CO-E-, -E-CO—F, -E-S—, -E-S—F—, -E-NR—C—S—, -E-NR—CS—F—; where E and F are the same or different and are independently chosen from linear or branched —(OCH i and j, identical or different, are integers and independently chosen from 0, 1 to 2000; Z is linear or branched -Alkyl-; p is 0 or 1; and Z′ represents H, a thiol protecting group COR, R n, n′, equal or different are 0 or 1; q is 0, 1 or 2; R and R′ are equal or different and independently chosen from H, Alkyl, Aryl, each being optionally substituted by Hal, CN, NRR′, CF