Patent ID: 6388090
Filing Date: 2002-05-14
Classification: C07D

Abstract:
An imidazole derivative of formula (I): wherein X is â€”CH2â€”(CH2)pâ€”, â€”Oâ€”, &boxH;NH or â€”Sâ€”; R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, C3-C7-cycloalkyl, C5-C7-cycloalkenyl, C5-C7-cycloalkynyl or a mono- or bicyclic aromatic or partially or fully saturated heterocyclic group with 5 to 10 ring atoms which are carbon atoms and one to three heteroatoms selected from N, O and S; wherein the said phenyl, naphthyl,1,2,3,4-tetrahydronaphthyl, C3-C7-cycloalkyl, C5-C7-cycloalkenyl, C5-C7-cycloalkynyl or mono- or bicyclic aromatic or partially or fully saturated heterocyclic group is optionally substituted with one to three substituents selected independently from halogen, â€”OH, â€”NH2, halo-C1-C6-alkyl, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, OHâ€”(C1-C6)-alkyl, NH2â€”(C1-C6)-alkyl and mono- or di(C1-C6-alkyl)amino; R2 is H or C1-C6-alkyl; R3 is H or C1-C6-alkyl; R4 is H or C1-C6-alkyl; R5 is H, or R5 and R7 form together a bond; each R6 is independently halogen, â€”OH, â€”NH2, halo-C1-C6-alkyl, C1-C6-alkyl, C1-C6-alkoxy or OHâ€”(C1-C6)-alkyl; R7 is H, OH or C1-C4-alkyl, or R7 and R5 form together a bond; each R8 is independently OH, C1-C6-alkyl, halo-C1-C6-alkyl or C1-C6-alkoxy; m is 0,1,2 or 3; n is 0 or 1; p is 0 or 1; r is 0 or 1; and t is 0,1 or 2; or a pharmaceutically acceptable ester or salt thereof.