Patent ID: 9056860
Filing Date: 2015-06-16
Classification: A61P,C07D,Y02P

Abstract:
1. A process for making a compound of formula I: or a pharmaceutically acceptable salt thereof, comprising (A) coupling a compound of formula (i) with a compound of formula (ii) in the presence of a metal catalyst which is PdCl (B) deprotecting a compound of formula (iii) to yield a compound of formula (iv): or a salt thereof; (C) contacting the compound of formula (iv) with (5)-2-(methoxycarbonylamino)-3-methylbutanoic acid: to yield a compound of formula I; wherein each PG independently is an amine protecting group; Y is —B(OR)(OR′) and Z is Br; and R and R′ are independently selected from the group consisting of hydrogen and straight or branched C