Patent ID: 7435729
Filing Date: 2008-10-14
Classification: A61P,C07D

Abstract:
1. A method for modulating ER-β in a breast cancer cell or bone cancer cell expressing ER-β, comprising contacting the cell with an effective amount of a compound having the structure: or a pharmaceutically acceptable salt thereof; wherein a is 0, 1 or 2; A, B and C are independently CH, CR or N; D is —(CH R R R and wherein R R X is at each occurrence independently a direct bond; —(CH Y is at each occurrence independently halogen; —R optionally fused on adjacent carbon atoms with one or two phenyl or cycloalkyl rings, and with each carbon optionally and independently substituted with carbonyl or with one or two substituents independently selected from R or where —X—Y is Z is CH G is O, S or NR n and m are at each occurrence independently 0, 1, 2 or 3; p is at each occurrence independently 1, 2 or 3; q is at each occurrence independently 0, 1 or 2; r is at each occurrence independently 1, 2, 3, 4 or 5; s is at each occurrence independently 0, 1, 2, 3 or 4; R is at each occurrence independently C R R R