Patent ID: 9102718
Filing Date: 2015-08-11
Classification: A61K,A61P,C07K

Abstract:
1. A method selected from the group consisting of: (a) a method of treating a subject having an occult or minimally classic choroidal neovascularization lesion, comprising administering an anti-sphingosine-1-phosphate (S1P) antibody or S1P-binding antibody fragment in an amount sufficient to reduce the size of the choroidal neovascularization lesion; (b) a method of treating retinal pigment epithelial detachment, comprising administering to an affected eye of a subject having or suspected of having retinal pigment epithelial detachment, an anti-S1P antibody or S1P-binding antibody fragment in an amount sufficient to stabilize or decrease the retinal pigment epithelial detachment; (c) a method of reducing central retinal thickness in an eye of a subject having an occult or minimally classic choroidal neovascularization lesion, comprising administering an anti-S1P antibody or S1P-binding antibody fragment in an amount sufficient to cause a reduction in central retinal thickness of the eye; and (d) a method for preserving or improving visual acuity in a patient having or suspected of having an occult or minimally classic choroidal neovascularization lesion, comprising administering an anti-S1P antibody or S1P-binding antibody fragment in an amount sufficient to preserve or improve visual acuity.