Patent ID: 6428812
Filing Date: 2002-08-06
Classification: A61K,A61P,Y10S

Abstract:
A process for manufacturing granules containing angiotensin-converting enzyme inhibiting peptides for oral administration, which comprises the steps of:a) purifying the supernatant of the solid-liquid separation of a lactic acid fermentation of whey to remove the lactic acid and other impurities to form a purified whey having angiotensin-converting enzyme inhibiting properties; b) spraying the purified whey of the lactic acid fermentation onto seed granules in a mixing fluid bed processor to form preliminary granules; c) treating the preliminary granules to reduce their size to form powder; d) returning the powder obtained in step c) to a mixing fluid bed processor, and, e) spraying additional purified whey onto the returned powder while fluidizing the returned powder in a mixing fluid bed processor to form the granules for oral administration.