Patent ID: 6077865
Filing Date: 2000-06-20
Classification: A61K

Abstract:
A method of preparation of a topical antifungal formulation comprising the sequential steps of:a) combining quantities of tolnaftate, cetaryl alcohol, emulsifying wax, cetyl alcohol, stearyl alcohol, olyl alcohol and methyl paraben in a first vessel to form a first mixture;b) heating the first mixture until the first mixture forms a clear liquid;c) heating a quantity of water to between 75 and 85 degrees Centigrade in a second vessel;d) combining quantities of cetyl trimethyl ammonium chloride, octoxynol-9, imidazolidinyl urea, and the quaternary ammonium compound into the heated water of the second vessel to form a second mixture;e) mixing the second mixture for approximately 10 minutes;f) combining the first and the second mixtures in the second vessel thoroughly;g) stirring the combined mixture in the second vessel for approximately 15 minutes and cooling to room temperature to achieve a smooth lotion of homogeneous composition.