Patent ID: 6838569
Filing Date: 2005-01-04
Classification: C07D

Abstract:
1. A process for the purification of paclitaxel trihydrate and docetaxel trihydrate comprising: (a) treating at least one crude taxane selected from the group consisting of paclitaxel and docetaxel of chromatographic assay of 40-55% with a mixture of dichloromethane and hexane to obtain a product; (b) dissolving the product obtained in (a) in acetone followed by addition of hexane to increase chromatographic purity and provide a product of step (b); (c) dissolving the product of step (b) in acetonitrile at a temperature of 50-70° C.; (d) adding purified water to a product of step (c) to precipitate the taxane; and (e) filtering and drying a product of step (d) to obtain at least one taxane trihydrate selected from the group consisting of paclitaxel trihydrate and docetaxel trihydrate.