Patent ID: 6660747
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound of the formula (I): wherein: X is â€”CHR5â€”, â€”CHR5-alkyl-, or â€”CHR5-alkenyl-;R1 is selected from the group consisting of: â€”R4â€”CR3â€”Zâ€”R6-alkyl; â€”R4â€”CR3â€”Zâ€”R6-alkenyl; â€”R4â€”CR3â€”Zâ€”R6-aryl; â€”R4â€”CR3â€”Zâ€”R6-heteroaryl; â€”R4â€”CR3â€”Zâ€”R6-heterocyclyl; R4â€”CR3â€”Zâ€”H; â€”R4â€”NR7â€”CR3â€”R6-alkyl; â€”R4â€”NR7CR3â€”R6-alkenyl; â€”R4â€”NR7â€”CR3â€”R6-aryl; â€”R4â€”NR7â€”CR3â€”R6-heteroaryl; â€”R4â€”NR7â€”CR3â€”R6-heterocyclyl; and â€”R4â€”NR7â€”CR3â€”R8; each Z is independently â€”NR5â€”, â€”Oâ€”, or â€”Sâ€”; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -alkyl-Y-alkyl; -alkyl-Y-alkenyl; -alkyl-Y-aryl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R5)2; â€”COâ€”N(R5)2; â€”COâ€”C1-10alkyl; â€”COâ€”Oâ€”C1-10alkyl; â€”N3; -aryl -heteroaryl; -heterocyclyl; â€”CO-aryl; and â€”CO-heteroaryl; each R3 is &boxH;O or &boxH;S; each R4 is independently alkyl or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; each R5 is independently H or C1-10alkyl; R6 is a bond, alkyl, or alkenyl, which may be interrupted by one or more â€”Oâ€” groups; R7 is H, C1-10 alkyl, or arylalkyl; or when R4 is alkyl and R7 is C1-10 alkyl, R4 and R7 can join together to form a piperidine ring; R8 is H or C1-10 alkyl; each Y is independently â€”Oâ€” or â€”S(O)0-2â€”; n is 0 to 4; and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, hydroxy, halogen and trifluoromethyl; or a pharmaceutically acceptable salt thereof.