Patent ID: 9028831
Filing Date: 2015-05-12
Classification: A61P,C12Q

Abstract:
1. A method of treating colorectal cancer comprising (i) determining the levels of APTX in a sample isolated from a patient having colorectal cancer, (ii) selecting a patient for said treatment if low APTX expression levels with respect to a reference value are detected in said sample, and (iii) administering a topoisomerase I inhibitor to said patient, wherein the topoisomerase I inhibitor is selected from the group consisting of topotecan, gimatecan, irinotecan, camptothecin, SN 38 and its analogues, 9-nitrocamptothecin and the macromolecular camptothecin conjugate PNU-166148, 10-hydroxycamptothecin acetate salt, idarubicin hydrochloride, irinotecan hydrochloride; teniposide, topotecan hydrochloride, doxorubicin, epirubicin hydrochloride, mitoxantrone hydrochloride and daunorubicin hydrochloride.