Patent ID: 6166260
Filing Date: 2000-12-26
Classification: C07B,C07C,C07F

Abstract:
A method for obtaining an enantiomeric excess of a reaction product through a tandem process comprising the steps of:enantioselectively reducing a chemical entity that has a carbonyl group or carbonyl equivalent by admixing the chemical entity with a metal hydride complex which is derived from a metal hydride and which comprises a chiral ligand and at least two equivalents of hydrides to form a reaction mixture and allowing the reaction mixture to react for a time sufficient to reduce the carbonyl group or carbonyl equivalent, thus forming a reduction product in a solution that contains a solvent;quenching the reaction to terminate the reaction;allowing the quenched reaction mixture to stand for a period of time sufficient to form crystals comprising the ligand and the reduction product; andrecovering the reduction product from the crystals.