Patent ID: 6248713
Filing Date: 2001-06-19
Classification: A61K,A61P,C07K,Y10S

Abstract:
A cell adhesion inhibitory compound of formula (I),Z--(Y.sup.1)--(Y.sup.2)--(Y.sup.3).sub.n --X (I)whereinY.sup.1 is --N(R.sup.1)--C(R.sup.2) (A.sup.1)--C(.dbd.O)--,Y.sup.2 is --N(R.sup.1)--C(R.sup.2) (A.sup.2)--C(.dbd.O)--,each Y.sup.3, independently, is represented by the formula --N(R.sup.1)--C(R.sup.2)(A.sup.3)--C(.dbd.O)--; andn is an integer from 0 to 8; whereineach R.sup.1, independently, is hydrogen, alkyl, or aralkyl; andeach R.sup.2, independently, is hydrogen, or alkyl; and wherein the compound has the moieties listed in one of a) to r):a) Z=3-methoxy-4-(N'-phenylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;b) Z=3-methoxy-4-(N'-phenylurea)phenylacetyl, A.sup.1 =the side chain of Met, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;c) Z=6-methoxy-5-(N'-(2-methylphenyl)-urea)-2-pyridylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;d) Z=4-(N'-2-hydroxy-phenylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;e) Z=PUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;f) Z=4-(N'-2-hydroxy-phenylurea)phenylacetyl, A.sup.1 =the side chain of Met, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;g) Z=3-methoxy-4-(N'-phenylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=NH.sub.2 ;h) Z=2-MPUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=NH.sub.2 ;i) Z=2-MPUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;j) Z=2-MPUA.sup.1 =the side chain of Met, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;k) Z=4-(N'-2-pyridylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;l) Z=3-methoxy-4-(N'-(2-methylphenyl)-urea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=NH2;m) Z=2-MPUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro or Ser, X=OH;n) Z=2-MPUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, Ser, or Thr, X=OH;o) Z=2-MPUA.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val, X=OH;p) Z=4-(N-(6-methyl-2-pyridyl)urea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH;q) Z=4-(N-2-fluorophenylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH; orr) Z=4-(N'-2-pyridylurea)phenylacetyl, A.sup.1 =the side chain of Leu, A.sup.2 =the side chain of Asp, A.sup.3 =the side chain of Val or Pro, X=OH.