Patent ID: 6169103
Filing Date: 2001-01-02
Classification: A61K,C07C

Abstract:
A compound of Formula I ##STR74## wherein R and R.sup.1 are the same or different and are hydrogen, alkyl, halogen, nitro, cyano, trifluoromethyl, OCF.sub.3, OCF.sub.2 H, OCH.sub.2 F, --OR.sup.6 wherein R.sup.6 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, or cycloalkyl, ##STR75## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR76## wherein R.sup.6 is as defined above, ##STR77## wherein R.sup.6 is as defined above, ##STR78## wherein R.sup.6 is as defined above, --SR.sup.6 wherein R.sup.6 is as defined above, ##STR79## wherein R.sup.6 is as defined above, --CH.sub.2 --OR.sup.6 wherein R.sup.6 is as defined above, ##STR80## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR81## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR82## wherein R.sup.6 is as defined above, ##STR83## wherein R.sup.6 is as defined above, cycloalkyl, or heteroaryl; R.sup.1a is fluorine; m is an integer of from 1 to 4; R.sup.2 is --OR.sup.6 wherein R.sup.6 is as defined above, or ##STR84## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6 ; R.sup.3, R.sup.3a, R.sup.4, and R.sup.4a are the same or different and are hydrogen, fluorine, alkyl, --(CH.sub.2).sub.n -aryl wherein n is an integer from 1 to 6, --(CH.sub.2).sub.n -heteroaryl wherein n is as defined above, --(CH.sub.2).sub.n -cycloalkyl wherein n is as defined above, --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -aryl wherein X is O, S, SO, SO.sub.2, or NH, and p and q are each zero or an integer of 1 to 6, and the sum of p+q is not greater than six, --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -heteroaryl wherein X, p, and q are as defined above, or --(CH.sub.2).sub.n --R.sup.7 wherein R.sup.7 is N-phthalimido, N-2,3-naphthylimido, --OR.sup.6 wherein R.sup.6 is as defined above, ##STR85## wherein R.sup.6 and R.sup.6a are the same or different and as defined above for R.sup.6, --SR.sup.6 wherein R.sup.6 is as defined above, ##STR86## wherein R.sup.6 is as defined above, ##STR87## wherein R.sup.6 is as defined above, ##STR88## wherein R.sup.6 is as defined above, ##STR89## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, ##STR90## wherein R.sup.6 is as defined above, ##STR91## wherein R.sup.6 is as defined above, ##STR92## wherein R.sup.6 is as defined above, or ##STR93## wherein R.sup.6 and R.sup.6a are the same or different and are as defined above for R.sup.6, and n is as defined above; R.sup.5 is OH, SH; or OR.sup.5a wherein R.sup.5a is alkyl, arylalkyl, cycloalkyl, or acyloxymethyl; with the proviso that R.sup.3, R.sup.3a, R.sup.4, and R.sup.4a are hydrogen or at least one of R.sup.3, R.sup.3a, R.sup.4, or R.sup.4a is fluorine; and corresponding isomers thereof; or a pharmaceutically acceptable salt thereof.