Patent ID: 6716858
Filing Date: 2004-04-06
Classification: A61K,B65H,C07C,C07D,G01N,G03G

Abstract:
A method for treating a condition or disorder associated with oxidative stress, comprising administering to a hyperglycemic mammal an effective amount to treat the condition or disorder associated with oxidative stress of a compound of the general formula: wherein R1 is CH2NH2, CH2SH, COOH, CH2CH2NH2, CH2CH2SH, or CH2COOH;R2 and R6 is H, OH, SH, NH2, C 1-18 alkyl, alkoxy or alkene; R4 and R5 are H, C 1-18 alkyl, alkoxy or alkene; Y is N or C, such that when Y is N R3 is nothing, and when Y is C, R3 is NO2 or another electron withdrawing group, or salts thereof, and wherein the condition or disorder associated with oxidative stress is selected from the group consisting of arthritis, cancer, exposure to ionizing radiation, exposure to chemotherapeutic agents, pulmonary adult respiratory distress syndrome, strokes, pancreatitis, and intestinal ulcerations.