Patent ID: 8846389
Filing Date: 2014-09-30
Classification: A61K,C07K,C12N

Abstract:
1. A vector comprising a nucleic acid molecule selected from the group consisting of: a) a nucleic acid molecule encoding an AAV4 Rep protein comprising an amino acid sequence at least 91% identical to a sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 and SEQ ID NO:11; and, b) a nucleic acid molecule encoding an AAV4 Cap protein comprising an amino acid sequence at least 80% identical to a sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:16 and SEQ ID NO:18; wherein the nucleic acid molecule encodes a polypeptide having at least one activity selected from the group consisting of i) binding an AAV4 ITR, ii) binding nucleotide triphosphate (NTP), iii) being capable of forming an AAV4 particle and iv) specifically binding an antibody made against an AAV4 Rep protein or an AAV4 Cap protein.