Patent ID: 6545015
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A method of treating a subject afflicted by or susceptible to an infection, wherein said subject is selected from the group consisting of a mammal, a plant and a culture, said method comprising administering to the subject a therapeutically-effective amount of the compound of the Formula: (a) wherein Ar is selected from the group consisting of aryl and heteroaryl; (b) wherein each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, provided that at least two of R1, R2, R3 and R4 is hydrido; (c) wherein each of R5, R6, R7, and R8 is independently selected from the group consisting of hydrido and lower alkyl; (d) wherein Het is selected from the group consisting of â€ƒwherein each of R11, R12 and R13 is independently selected from the group consisting of nitro, halo, hydroxy, lower amino, lower alkyl, lower alkoxy, aryloxy, lower carboalkoxy, sulfinyl, sulfonyl, carboxy, lower thio, and sulfoxy.