Patent ID: 6521630
Filing Date: 2003-02-18
Classification: A61P,C07D

Abstract:
A compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein:A is (CH2)n where n is equal to 0, 1 or 2, with the proviso that when n is 0 there is no bridging group A; U is NH or NR3, R1 and R2 are selected independently from H, (C1-C6)alkyl, Cl, F, CN, nitro, CF3, â€”NHC(O)R6 and â€”OR7; R3 is selected from the group consisting of (C1-C6)malkyl, C(&boxH;O)â€”(C1-C6)alkyl, where m=1 or 2; R4 and R5 are selected from H, (C1-C6)alkyl, Cl, F, â€”CF3, â€”CN, â€”NHC(&boxH;O)R6, â€”OR7, a 5- to 7-membered aryl or heteroaryl ring, where m, R6 and R7 are as defined above; and R6 and R7 are selected independently from H, (C1-C6)alkyl or a 5- to 7-membered aryl or heteroaryl ring; V is CH, CR3, or N; W is CH2 or C(O); X is C; Y is CH, CR1 or CR2 where R1 and R2 are as defined above.