Patent ID: 6737249
Filing Date: 2004-05-18
Classification: A61K,C07K

Abstract:
An isolated nucleic acid encoding an agonist antibody, fragment or variant thereof which binds to human c-mpl, wherein said antibody, fragment or variant thereof is selected from the group consisting of: Ab1, Ab2, Ab3, Ab4, Ab5 and Ab6, wherein each Ab1-Ab6 comprises a VH and VL chain, each VH and VL chain comprising CDR amino acid sequences designated CDR1, CDR2 and CDR3 separated by framework amino acid sequences, the amino acid sequence of each CDR in each VH and VL chain of Ab1-Ab6 is selected according to the following table:Ab1:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 1)(SEQ ID NO: 3)(SEQ ID NO: 5)(SEQ ID NO: 2)(SEQ ID NO: 4)(SEQ ID NO: 6)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 7)(SEQ ID NO: 9)(SEQ ID NO: 11)(SEQ ID NO: 8)(SEQ ID NO: 10)(SEQ ID NO: 12)Ab2:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 13)(SEQ ID NO: 15)(SEQ ID NO: 17)(SEQ ID NO: 14)(SEQ ID NO: 16)(SEQ ID NO: 18)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 19)(SEQ ID NO: 21)(SEQ ID NO: 23)(SEQ ID NO: 20)(SEQ ID NO: 22)(SEQ ID NO: 24)Ab3:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 25)(SEQ ID NO: 27)(SEQ ID NO: 29)(SEQ ID NO: 26)(SEQ ID NO: 28)(SEQ ID NO: 30)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 19)(SEQ ID NO: 21)(SEQ ID NO: 23)(SEQ ID NO: 20)(SEQ ID NO: 22)(SEQ ID NO: 24)Ab4:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 25)(SEQ ID NO: 31)(SEQ ID NO: 33)(SEQ ID NO: 26)(SEQ ID NO: 32)(SEQ ID NO: 34)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 35)(SEQ ID NO: 21)(SEQ ID NO: 23)(SEQ ID NO: 20)(SEQ ID NO: 22)(SEQ ID NO: 24)Ab5:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 36)(SEQ ID NO: 38)(SEQ ID NO: 40)(SEQ ID NO: 37)(SEQ ID NO: 39)(SEQ ID NO: 41)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 19)(SEQ ID NO: 21)(SEQ ID NO: 23)(SEQ ID NO: 20)(SEQ ID NO: 22)(SEQ ID NO: 24)Ab6:VHCDR1VHCDR2VHCDR3(SEQ ID NO: 42)(SEQ ID NO: 44)(SEQ ID NO: 46)(SEQ ID NO: 43)(SEQ ID NO: 45)(SEQ ID NO: 47)VLCDR1VLCDR2VLCDR3(SEQ ID NO: 48)(SEQ ID NO: 50)(SEQ ID NO: 52)(SEQ ID NO: 49)(SEQ ID NO: 51)(SEQ ID NO: 53).