Patent ID: 7173002
Filing Date: 2007-02-06
Classification: C07K

Abstract:
1. A method for inhibiting TGF-β1 activity in a biological tissue of an animal comprising an administration thereto of an effective amount of a protein comprising a sequence selected from the group consisting of: a) SEQ ID NO:2 b) amino acids 694–712 of SEQ ID NO:2; c) amino acids 651–683 of SEQ ID NO:2 d) a protein sequence having a tyrosine at position 703 of SEQ ID NO:2; e) a protein sequence having amino acids 21 to 1428 of SEQ ID NO:2 f) a protein sequence having amino acids 21 to 1404 of SEQ ID NO:2; and g) a protein sequence having a methionine instead of threonine at position 1224 of SEQ ID NO:2 thereby inhibiting TGF-βl activity in a biological tissue of an animal.