Patent ID: 6245540
Filing Date: 2001-06-12
Classification: A61K,C12N

Abstract:
An isolated polynucleotide comprising a nucleic acid sequence selected from the group consisting of:(a) a nucleic acid sequence cncoding the polypeptide set forth as amino acid residues 1 to 677 of SEQ ID NO:2;(b) a nucleic acid sequence encoding the polypeptide set forth as amino acid residues 2 to 677 of SEQ ID NO:2;(c) a nucleic acid sequence encoding the polypeptide set forth as amino acid residues 2 to 677, wherein said polypeptide has at least one conservative amino acid substitution, and further wherein said polypeptide retains enzymatic activity;(d) a nucleic acid sequence encoding a fragment of the polypeptide set forth as amino acid residues 1 to 677 of SEQ ID NO:2, wherein said polypeptide fragment has enzymatic activity;(e) a nucleic acid sequence encoding at least 30 contiguous amino acid residues of SEQ ID NO:2, wherein said amino acid residues bind an antibody which binds specifically to SEQ ID NO:2; and(f) a nucleic acid sequence complementary to the nucleic acid sequence of (a), (b), (c), (d) or (e).