Patent ID: 6531500
Filing Date: 2003-03-11
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A method of treating Epidermolysis bullosa, comprising applying to the skin an allantoin-containing composition in a therapeutically effective amount, the allantoin-containing composition applied to the skin consisting essentially of an oil-in-water emulsion consisting essentially of:(a) allantoin in a concentration of about 1.50%; (b) an emollient component comprising: (i) lanolin oil; (ii) cetyl alcohol; (iii) stearyl alcohol; and (iv) cod liver oil; and (c) butylated hydroxytoluene; (d) an emulsifier system comprising at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms; and (e) at least one acid selected from the group consisting of: (i) an organic acid of from 2 to 22 carbon atoms; and (ii) an inorganic acid selected from the group consisting of hydrochloric acid, sulfuric acid, and phosphoric acid to adjust the pH from about 4.5 to about 5.8; the allantoin being stable in the emulsion for at least 90 days at 40Â° C.