Patent ID: 9102717
Filing Date: 2015-08-11
Classification: A61P,C07K

Abstract:
1. A humanized antibody that specifically binds an epitope in apolipoprotein E (apoE), wherein the epitope comprises amino acid residues within amino acids 222-230 (SEQ ID NO:14) and 261-272 (SEQ ID NO:19) of apoE, wherein the humanized antibody comprises a heavy chain region and a light chain region, wherein the heavy chain region comprises a heavy chain variable region comprising complementarity determining regions (CDRs) having amino acid sequences set forth in SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4, and the light chain region comprises a light chain variable region comprising CDRs having amino acid sequences set forth in SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8.