Patent ID: 6210670
Filing Date: 2001-04-03
Classification: A61K,A61P,C07K

Abstract:
A recombinant monoclonal antibody comprising a first amino acid sequence from a first immunoglobulin and a second amino acid sequence from a second immunoglobulin, and having a binding site that specifically binds to P-selectin and to E-selectin, whereinthe specific binding of the antibody to the P-selectin inhibits binding of the P-selectin to a counterreceptor of P-selectin; andthe specific binding of the antibody to the E-selectin inhibits binding of the E-selectin to a counterreceptor of E-selectin, andwherein an excess of antibody reduces the quantity of receptor bound to counterreceptor by at least 60% as measured in an in vitro competitive binding assay.