Patent ID: 6278022
Filing Date: 2001-08-21
Classification: C07C

Abstract:
A method for making compounds having the structural formula ##STR20##wherein:X isi) phenyl, lower phenylalkoxy, phenoxy, or benzyl; orii) at least two substituents, a first substituent being selected from the group consisting of phenyl, lower phenylalkoxy, phenoxy, and benzyl, and a second substituent being selected from the group consisting of C.sub.1 -C.sub.4 alkoxy, halogen, lower alkyl, and lower alkylthio; oriii) along with the phenyl to which it is attached, forms a multiple fused ring heterocycle;wherein the method comprises the steps of:A) selecting as a starting material a compound of the structural formula ##STR21##B) dissolving compound I in an organic solvent selected from the group consisting of methyl t-butyl ether, ethylene glycol dimethyl ether, 2-methoxyethyl ether, acetonitrile, and acetic acid;C) nitrating the dissolved compound I with nitric acid to form a compound of the structural formula ##STR22##andD) reducing the nitro group of compound II and adding hydrochloric acid to form the compound of the structural formula: ##STR23##