Patent ID: 6207680
Filing Date: 2001-03-27
Classification: A61P,C07C,C07D,C07F

Abstract:
A compound having the formula: ##STR133##wherein,X is --O--, --S--, ##STR134##R.sub.2 is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, and phenylsulfonyl groups, wherein aryl is as defined hereinafter;p is 1 or 2;Y is hydrogen, lower alkyl, hydroxy, chlorine, fluorine, bromine, iodine, lower alkoxy, trifluoromethyl, nitro, or amino, when p is 1;Y is lower alkoxy, hydroxy or halogen when p is 2 and X is --O--;in which R.sub.1 is R.sub.20, R.sub.21 or R.sub.22, wherein:R.sub.20 is --(CH.sub.2).sub.n --, where n is 2, 3, 4 or 5;R.sub.21 is--CH.sub.2 --CH.dbd.CH--CH.sub.2 --,--CH.sub.2 --C.tbd.C--CH.sub.2 --,--CH.sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --,--CH.sub.2 --CH.sub.2 --CH.dbd.CH--CH.sub.2 --,--CH.sub.2 --C.tbd.C--CH.sub.2 --CH.sub.2 --, or--CH.sub.2 --CH.sub.2 --C.tbd.C--CH.sub.2 --,the --CH.dbd.CH-- bond being cis or trans;R.sub.22 is R.sub.20 or R.sub.21 in which one or more carbon atoms of R.sub.20 or R.sub.21 are substituted by at least one C.sub.1 -C.sub.6 linear alkyl group, phenyl group or ##STR135##where Z.sub.1 is lower alkyl, --OH, lower alkoxy, --CF.sub.3, --NO.sub.2, --NH.sub.2 or halogen, and p is as previously defined;where R.sub.12 is selected from the group consisting of:hydrogen, ##STR136##where R.sub.13 is selected from the group consisting of hydrogen and (C.sub.1 -C.sub.12) alkyl groups;where R.sub.14 is selected from the group consisting of hydrogen and (C.sub.1 -C.sub.12) alkyl groups;where NR.sub.15 R.sub.16 taken together form a ring structure selected from the group consisting of piperidinyl, morpholinyl and piperazinyl;where R.sub.17 is selected from the group consisting of lower alkyl and aryl groups;in which aryl is phenyl or ##STR137##where R.sub.5 is hydrogen, lower alkyl, lower alkoxy, hydroxy, chlorine, fluorine, bromine, iodine, lower monoalkylamino, lower dialkylamino, nitro, cyano, trifluoromethyl, or trifluoromethoxy;all geometric, optical, and stereoisomers thereof; or a pharmaceutically acceptable acid addition salt thereof.