Patent ID: 7676328
Filing Date: 2010-03-09
Classification: C12N,G01N

Abstract:
1. A method for identifying proteins specific to a modified cell type, the method comprising the following steps: a) determining experimentally topological protein combination patterns of a plurality of individual cells or cell membranes from a sample of healthy cells; b) determining experimentally topological protein combination patterns of a plurality of individual cells or cell membranes from a sample of pathologically or physiologically modified cells of the same cell type as the healthy cells of a); c) subtracting the coincident parts of the topological protein combination patterns determined in a) and b) from the protein combination patterns determined in b), leaving a residual topological protein combination pattern comprising one or more proteins, wherein said one or more proteins of the residual topological protein combination pattern of step c) are identified as proteins specific to said modified cell type; and d) outputting said identified proteins.