Patent ID: 8735602
Filing Date: 2014-05-27
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A process for the preparation of a metal salt of D-isoglutamyl-D-tryptophan of formula I wherein M is potassium, said process comprising: (a) reacting D-isoglutamyl-D-tryptophan in water with potassium hydroxide thereby forming a solution; (b) concentrating the solution to an oil; (c) adding isopropanol with stirring to the oil to cause precipitation of the salt thereby forming a precipitate; (d) recovering the precipitate; and (e) vacuum drying the precipitate to obtain the potassium salt of formula I or (f) reacting an ammonium salt represented by formula VII in an aqueous solution with one equivalent of potassium hydroxide; (g) evaporating the aqueous solution to give a solid; and (h) mixing the solid with water and isopropanol to obtain the potassium salt of formula I.