Patent ID: 6311690
Filing Date: 2001-11-06
Classification: A61F,A61L,Y10S

Abstract:
A method of making a biocompatible, osteogenic bone repair composition, said method comprising:a) dispersing a plurality of osteoinductive protein based particles in an aqueous solution of about 0.002 to about 0.25 weight percent of a crosslinking agent and surface activating or partially crosslinking said particles, said protein-based particles selected from the group consisting of demineralized bone matrix, mixtures of demineralized bone matrix and collagen, demineralized bone matrix extracted with a chaotropic agent and complexed with bone morphogenetic protein, reconstituted collagen complexed with bone morphogenctic protein, or mixtures of demineralized bone matrix extracted with a chaotropic agent and collagen complexed with bone morphogenetic protein; andb) removing the particles of step (a) from the aqueous solution; andc) milling the particles of step (b) into a powder.