Patent ID: 6297247
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A method of inhibiting a matrix metalloproteinase, the method comprising administering to a patient in need of matrix metalloproteinase inhibition a matrix metalloproteinase inhibiting amount of a compound of Formula I ##STR13##wherein:Ar is selected from phenyl;phenyl substituted with alkyl, --NO.sub.2, halogen, --OR.sup.5, --CN, --CO.sub.2 R.sup.5, --SO.sub.3 R.sup.5, --CHO, --COR.sup.5, --CONHR.sup.5, --NHR.sup.5, or --NHCOR.sup.5 ;heteroaryl; or2-naphthyl;R.sup.1 is hydrogen, methyl, --NO.sub.2, --Cl, --NH.sub.2, --NHCO.sub.2 CH.sub.3, --OH, or --CO.sub.2 H;R.sup.2 and R.sup.3 are the same or different and are independently selected from hydrogen, alkyl, --(CH.sub.2).sub.v -aryl, --(CH.sub.2).sub.v -heteroaryl, --(CH.sub.2).sub.v -cycloalkyl, --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -aryl, --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -heteroaryl, --(CH.sub.2).sub.t --NR.sup.6 R.sup.6a, --(CH.sub.2).sub.v --R.sup.7, --(CH.sub.2).sub.v --CO.sub.2 R.sup.5, --(CH.sub.2).sub.v --CONR.sup.6 R.sup.6a, or --(CH.sub.2).sub.v --SR.sup.5 ;m is zero or 1;Y is CH;z is zero or 1;W is --CHR.sup.8 ;n is zero or 1;R.sup.4 is --OH, --NR.sup.6 R.sup.6a, or --NHOR.sup.9 ;R.sup.5 is hydrogen or alkyl;v is 1 to 5;X is O or S;p and q are independently 1 to 5, provided that p+q is not greater than 5;t is 1 to 9;R.sup.6 and R.sup.6a are each the same or different and are hydrogen or alkyl;R.sup.7 is 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl, or 1,3-dihydro-1,3-dioxo-benzo[f]isoindol-2-yl;R.sup.8 is hydrogen or alkyl;R.sup.9 is hydrogen, alkyl, or benzyl; ora pharmaceutically acceptable salt thereof.