Patent ID: 6953860
Filing Date: 2005-10-11
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a compound of the formula I wherein R comprising reacting a compound of formula III wherein R 3 and R 4 are as described above, with a compound of formula IV wherein R 1 and R 2 are as decribed above, to form a compound of formula V which is not isolated wherein R 1 , R 2 and R 4 are as decribed above, reacting the reaction mixture of compound of formula V with an alcohol to form a reaction mixture comprising the corresponding ester of formula VI wherein R is lower alkyl, R 1 , R 2 and R 4 are as decribed above, and without isolating the ester of formula VI reacting the reaction mixture of ester of formula VI with N-methylhydroxylamine hydrochoride and a base to form the compound of formula I.