Patent ID: 7160868
Filing Date: 2007-01-09
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of inhibiting proliferation of a human tumor cell overexpressing Nr-CAM in a subject comprising administering locally to the subject, at the site or former site of a tumor, a Nr-CAM antisense nucleic acid comprising the complement of nucleotides 119 to 1434 of SEQ ID NO.: 1; wherein the human tumor cell overexpressing Nr-CAM is from a glioblastoma, a glioma, an astrocytoma, or an oligodendroglioma, and wherein the Nr-CAM antisense nucleic acid is administered in an amount effective to inhibit tumorigenesis by inhibiting proliferation of the human tumor cell overexpressing Nr-CAM.