Patent ID: 7435821
Filing Date: 2008-10-14
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of formula IIIc: comprising: (d) contacting the compound of formula IIa with 2-hydroxy-pyridine in the presence of a catalyst and a fourth aprotic solvent to form a compound of formula IIb; (e) contacting a compound of formula I with a compound of formula IIb in the presence of a second base to form a compound of formula IIIc; wherein: Z is selected from Cl, Br, I, OSO ring D is selected from phenyl, 2-fluorophenyl, 3-chlorophenyl, and 4-methoxyphenyl; R R is selected from Cl, Br, I, C R alternatively, NR ring A is substituted with 0-1 R B is selected from F, Cl, Br, I, OSO R