Patent ID: 7504538
Filing Date: 2009-03-17
Classification: A61P,C07C

Abstract:
1. A compound having the formula: wherein Z′ is —(CH Z is selected from a C Ar is an aryl group independently selected from an aromatic carbocyclic ring system, a five- or six-membered heteroaromatic ring system and a bicyclic heteroaromatic ring system; R (a) H; (b) C (c) C (d) C wherein the substituents (b)-(d) optionally have at least one substituent independently selected from a group (e)-(i) consisting of: (e) Ar, —O—Ar or —S—Ar; (f) OH, O-alkyl or S-alkyl, where alkyl is selected from the substituents (b)-(c); (g) —NR (h) —NH—C(O)-alkyl, —C(O)-alkyl, —O—C(O)-alkyl or —S—C(O)-alkyl, where alkyl is selected from the substituents (b)-(c); and (i)F, Cl or Br; R Ar optionally has at least one substituent independently selected from the substituents (b)-(i); or a tautomer, solvate or pharmaceutically acceptable salt of said compound.