Patent ID: 7427686
Filing Date: 2008-09-23
Classification: C07D

Abstract:
1. Compounds of the following: (1) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2R)-3-methylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (2) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2R)-3-ethylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (3) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2R)-3-propylamino-2-hydroxy}propyloxy]phenyl)chroman; (4) (3R,4R)-4-(4-[{(2R)-3-Butylamino-2-hydroxy }propyloxy]phenyl)-2,2-dimethyl-7-methoxy-3-phenylchroman; (5) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2R)-3-pentylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (6) (3R,4R)-2,2-Dimethyl-4-(4-[{(2R)-3-dimethylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3-phenylchroman; (7) (3R,4R)-4-(4-[{(2R)-3-Diethylamino-2-hydroxy}propyloxy]phenyl)-2,2-dimethyl-7-methoxy-3-phenylchroman; (8) (3R,4R)-2,2-Dimethyl-4-(4-[{(2R)-3-dipropylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3-phenylchroman; (9) (3R,4R)-4-(4-[{(2R)-3-Dibutylamino-2-hydroxy}propyloxy]phenyl)-2,2-dimethoxy-3-phenylchroman; (10) (3R,4R)-2,2-Dimethyl-4-(4-[{(2R)-3-dipentylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3 -phenylchroman; (11) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2R)-3-pyrrolidino-2-hydroxy}propyloxy]phenyl)-chroman; (12) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2R)-3-piperidino-2-hydroxy}propyloxy]phenyl)-chroman; (13) (3R,4R)-2,2-Dimethyl7-methoxy-3-phenyl-4-(4-[{(2R)-3-morpholino-2-hydroxy}propyloxy]phenyl)-chroman; (14) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2R)-3-piperazino-2-hydroxy}propyloxy]phenyl)-chroman; (15) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2R)-3-cyclohexylamino-2-hydroxy}propyloxy]phenyl)-chroman; (16) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2S)-3-methylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (17) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2S)-3-ethylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (18) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-propylamino-2-hydroxy}propyloxy]phenyl)-chroman; (19) (3R,4R)-4-(4-[{(2S)-3-Butylamino-2-hydroxy}propyloxy]phenyl)-2,2-dimethyl-7-methoxy-3-phenylchroman; (20) (3R,4R)-2,2-Dimethyl-7-methoxy-4-(4-[{(2S)-3-pentylamino-2-hydroxy}propyloxy]phenyl)-3-phenylchroman; (21) (3R,4R)-2,2-Dimethyl-4-(4-[{(2S)-3-dimethylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3-phenylchroman; (22) (3R,4R)-4-(4-[{(2S)-3-Diethyiamino-2-hydroxy}propyloxy]phenyl)-2,2-dimethyl-7-methoxy-3-phenylchroman; (23) (3R,4R)-2,2-Dimethyl-4-(4-[{(2S)-3-dipropylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3 -phenylchroman; (24) (3R,4R)-4-((4-[{(2S)-3-Dibutylamino-2-hydroxy}propyloxy]phenyl)-3-phenyl) -2,2-dimethoxy-3-phenylchroman; (25) (3R,4R)-2,2-Dimethyl-4-(4-[{(2S)-3-dipentylamino-2-hydroxy}propyloxy]phenyl)-7-methoxy-3-phenylchroman; (26) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-pyrrolidino-2-hydroxy}propyloxy]phenyl)-chroman; (27) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-piperidino-2-hydroxy}propyloxy]phenyl)-chroman; (28) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-morpholino-2-hydroxy}propyloxy]phenyl)-chroman; (29) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-piperazino-2-hydroxy}propyloxy]phenyl)-chroman; and (30) (3R,4R)-2,2-Dimethyl-7-methoxy-3-phenyl-4-(4-[{(2S)-3-cyclohexylamino-2-hydroxy}propyloxy]phenyl)-chroman.