Patent ID: 6897290
Filing Date: 2005-05-24
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A modified form of a regulator of complement activation protein (RCA protein) wherein the RCA protein is selected from the group consisting of complement receptor 1, decay accelerating factor, membrane cofactor protein, C4 binding protein, factor H, and these RCA proteins wherein the carboxy terminus of the RCA protein is removed to allow the protein to be secreted, wherein the modified form is selected from the group consisting of: a) a hybrid RCA protein comprising short consensus repeats (SCRs) derived from two, different of the RCA proteins, b) a recombined RCA protein wherein the SCRs of the RCA protein are rearranged, and c) a truncated RCA protein consisting of three SCRs, wherein the modified form of the RCA protein binds C3b, C4b or C3b and C4b.