Patent ID: 6610299
Filing Date: 2003-08-26
Classification: A61K,B82Y,C07H,C07K,C12N,C12Y

Abstract:
A 4â€²-O-glycosyl-etoposide of the formula I: in whichR1 is a methyl, benzyl or thienyl group; R2 is a hydrogen atom, an acyl or tri-C1-C4-alkylsilyl protective group; R3 is a hydroxyl group, an acyl or tri-C1-C4-alkylsilyl protective group which is bonded via an oxygen atom, an amino, acetylamino, benzyloxycarbonylamino or dimethylamino group; R4 is a hydrogen atom or a methyl group; R5 is a hydrogen atom, a hydroxyl group, an acyl or tri-C1-C4-alkylsilyl protective group which is bonded via an oxygen atom, or an amino, benzyloxycarbonylamino, azido or acetylamino group; R6 is a hydroxyl group, an acyl or tri-C1-C4-alkylsilyl protective group which is bonded via an oxygen atom, or an amino, benzyloxycarbonylamino or azido group; R7 is a hydrogen atom, an acyl or tri-C1-C4-alkylsilyl protective group; and R8 is a methyl or hydroxymethyl group or an acyl protective group which is bonded to the ring via an oxygen of an oxymethylene group, or a benzyloxycarbonyl group; where the acyl protective group is an acetyl, mono-, di- or trihalogenacetyl group.