Patent ID: 7049304
Filing Date: 2006-05-23
Classification: A61K,A61P,C07F

Abstract:
1. A method of treating a subject afflicted with a condition selected from the group consisting of Type II diabetes mellitus, impaired glucose tolerance, hypertension, coronary thrombosis, stroke, lipid syndromes, hyperglycemia, hypertriglyceridemia, hyperlipidemia, sleep apnea, hiatal hernia, reflux esophagisitis, osteoarthritis, gout, gallstones, kidney stones, pulmonary hypertension, infertility and cardiovascular disease, the method comprising the step of administering to the subject an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein: Z and Z′ are independently —O—, —NH— or —S—; Ar is a substituted or unsubstituted aryl group; X is an electron withdrawing group; R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups; Y is —H, an amine, —[NH—(CH q is an integer from 2 to about 10; r is an integer from 1 to about 5; R R