Patent ID: 8217036
Filing Date: 2012-07-10
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a cancer selected from the group consisting of leukemia, skin cancer, bladder cancer, breast cancer, uterus cancer, ovary cancer, prostate cancer, lung cancer, colon cancer, pancreas cancer, renal cancer, gastric cancer, brain cancer, soft-tissue sarcoma, and bone sarcoma comprising administering to a mammal in need thereof a compound of the Formula I: wherein: R wherein: R or one of R the dashed line - - - - - represents an optional second bond; R R R or two R R R R wherein Z is CH 2 , O, S(O) n or NR 10 and n is 0, 1 or 2; ee) halogen, ff) C 6 -C 14 aryl-S(O) 2 —NH—, gg) R 11 NHC(O)NH—O—, and hh) optionally substituted 5-membered monocyclic C 1 -C 4 heteroaryl attached to the triazine moiety via a nitrogen atom; R or R or R wherein a and b are each independently —CH C C optionally substituted aryl and heteroaryl groups are unsubstituted or are substituted with 1 or 2 moieties selected from the group consisting of: a) C and pharmaceutically acceptable salts thereof, in an amount effective to treat the cancer.