Patent ID: 6911457
Filing Date: 2005-06-28
Classification: A61K,A61P,C07C,C07D,C07H

Abstract:
1. A fluorinated anti-diabetic compound comprising a compound of the general Formulas I-IX: where for Formula I: R for Formula II: R for Formula III: R for Formula IV: R for Formula V: R for Formula VI: R for Formula VII: R for Formula VIII: R Wherein v is 6-9 inclusive, k is 0-11 inclusive, h is 1-12 inclusive, d is 0-4 inclusive with the proviso that if h=1 then k must be 5 or greater; wherein for the above Formulas I-VIII; X=fluoroalkyl, fluoroaryl, fluoroacyl, perfluoroalkyl, perfluoroaryl, perfluoroacyl, perfluoropolymer, F, CF where for Formula IX: R M represents any paramagnetic ion of the transition metal or lanthanide series; and for Formula XVII X represents fluoroalkyl, fluoroaryl, fluoroacyl, perfluoroalkyl, perfluoroaryl, perfluoroacyl, perfluoropolymer, F, CF Y represents multidentate metal complexing residues selected from the group consisting of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-aminoanilide), 5-amino-2-methoxyphenyl-1,4,7,10-tetraazacyclodo-decane-1,4,7,10-tetraacetic acid, 2-p-aminobenzyl-1,4,7,10-tetraazacyclodo-decane-1,4,7,10-tetraacetic acid, p-aminobenzyl-diethylenetriaminepentaacetic acid, p-isothiocyanatobenzyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, p-isothiocyanato-benzyldiethylene-triaminepentaacetic acid, p-isothiocyanatobenzyldiethylenetriaminepentaacetic acid, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(N-hydroxysuccinimidyl ester), 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid-t-butyl ester)-10-acetic acid, diethylenetriamine-pentaacetic acid, 1,4,7,10-tetraazacyclododecane, 1,4,7-triazacyclononane, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonic acid), and 10-(2-ethoxy-3,4-dioxo-1-cyclobutenyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid.