Patent ID: 6593354
Filing Date: 2003-07-15
Classification: A61P,C07D

Abstract:
A compound of formula (Ia): wherein: R1 represents optionally substituted aryl; R2 represents hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R3 is an alkylene chain, an alkenylene chain or an alkynylene chain; R5 represents hydrogen or C1-4 alkyl; R13 is selected from acyl, acylamino, alkoxy, alkoxycarbonyl, alkylenedioxy, alkylsulphinyl, alkylsulphonyl, alkylthio, aroyl, aroylamino, aryl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxycarbonyl, arylsulphinyl, arylsulphonyl, arylthio, carboxy, cyano, halo, hydrogen, hydroxy, nitro, trifluoromethyl, Y1Y2Nâ€”, Y1Y2NCOâ€”, Y1Y2NSO2â€”, Y1Y2Nâ€”C2-6 alkylene-Z1â€”, alkylC(&boxH;O)â€”Y1Nâ€”, alkylSO2â€”Y1Nâ€” or alkyl optionally substituted with aryl, hydroxy, or Y1Y2Nâ€”; L2 represents an alkylene or alkenylene linkage each optionally substituted by R6 (where R6 represents alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkenyl or cycloalkenylalkyl) or by alkyl substituted by hydroxy, â€”OR6, â€”Oâ€”C(&boxH;O)â€”R6 or â€”NY1Y2; Y1 and Y2 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl or cycloalkyl; X is O; Y is carboxy; and Z1 represents NR5; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates k of such compounds and their N-oxides and prodrugs.