Patent ID: 8273865
Filing Date: 2012-09-25
Classification: A61K,C07K

Abstract:
1. A polynucleotide molecule encoding a multivalent Clostridial toxin, wherein the multivalent Clostridial toxin comprises: a) a Clostridial toxin enzymatic domain capable of executing an enzymatic target modification step of a Clostridial toxin intoxication process; b) a Clostridial toxin translocation domain capable of executing a translocation step of a Clostridial toxin intoxication process; c) a first binding domain capable of executing a cell binding step of a Clostridial toxin intoxication process by selectively binding a first cell surface receptor displayed by the target cell; d) a second binding domain capable of executing a cell binding step of a Clostridial toxin intoxication process by selectively binding a second cell surface receptor displayed by the target cell; and e) a protease cleavage site, wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form.