Patent ID: 7803352
Filing Date: 2010-09-28
Classification: A61K

Abstract:
1. A method for selectively binding a contrasting complex to a blood clot or a thrombus on a plaque disposed within a body lumen comprising: administering an effective amount of a contrasting complex comprising a contrast material and a thrombolytic material, wherein said contrasting complex: (i) binds or adheres to said blood clot or said thrombus disposed within said body lumen via a fibrin portion of said thrombolytic material for a period of time sufficient to perform an invasive image-guided procedure, wherein said body lumen is selected from the group consisting of: the cardio-vascular system, the pulmonary system, the digestive system, the central nervous system, the reproductive system, and the excretory system; (ii) provides real-time visualization of said blood clot or said thrombus by a visualizing system during said invasive image-guided procedure, wherein said visualizing system is selected from the group consisting of: radiography systems, nuclear medicine systems, ultrasound systems, magnetic resonance systems and any combinations thereof; and (iii) exits said body without causing either kidney toxicity or stimulation of atherogenesis; and visualizing said blood clot or said thrombus by said visualizing system, wherein said contrast material renders radio-opaque said blood clot or said thrombus under x-ray imaging, and wherein said thrombolytic material is selected from the group consisting of: tissue plasminogen activator (tPA) tenecteplase form of TPAse, streptokinase, urokinase, retavase, and any mixtures thereof.