Patent ID: 6790942
Filing Date: 2004-09-14
Classification: A61K

Abstract:
A biologically active conjugate derivative having the following general formula (I)FE-L-Mâ€ƒâ€ƒ(I) where:M represents the corresponding radical of a biologically active molecule selected from the group consisting of proteins, peptides, and polypeptides; FE represents a functionalizing entity selected from the group consisting of PEG, PVP, PacM, dextran, hormones, antibodies, and antibody fragments; and L represents a linking arm comprising a dipeptide selected from the group consisting of Met-Nle, Met-&bgr;Ala, Gln-Gly, and Asp-Pro, which is capable of being cleaved by chemical treatment to leave Nle, &bgr;Ala, Gly or Pro, respectively, as a reporter group linked to M.