Patent ID: 6083952
Filing Date: 2000-07-04
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR40## wherein R.sup.1 and R.sup.2 independently represent hydrogen, C1 to 6 alkyl, C2 to 6 alkenyl, C2 to 6 alkynyl, C1 to 6 alkoxy, C1 to 6 alkylthio, halogen, hydroxy, trifluoromethyl or amino;R.sup.3 represents one or more substituents independently selected from hydrogen, C1 to 6 alkyl, C2 to 6 alkenyl, C2 to 6 alkynyl, C1 to 6 alkoxy, C1 to 6 alkylthio, halogen, hydroxy, trifluoromethyl, amino, cyano, nitro, trifluoromethoxy, methanesulphonyl, sulphamoyl, --NR.sup.4 R.sup.5, --COOR.sup.6, --CONR.sup.7 R.sup.8, benzyloxy, phenyl, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S, which phenyl or 5-membered heterocyclic aromatic ring is optionally substituted, the optionally substituents being C1 to 6 alkyl, halogen, cyano, nitro, hydroxy, C1 to 6 alkoxy, trifluoromethyl and trifluoromethoxy;R.sup.4, R.sup.5 and R.sup.6 independently represent hydrogen or C1 to 6 alkyl;R.sup.7 and R.sup.8 independently represent hydrogen, C1 to 6 alkyl or phenyl, which phenyl is optionally substituted by one or more groups independently selected from C1 to 6 alkyl, halogen, cyano, nitro, hydroxy, C1 to 6 alkoxy, trifluoromethyl and trifluoromethoxy;X represents --(CH.sub.2).sub.n --, wherein n represents zero or 1; andA represents a benzo or naphtho ring system;or a pharmaceutically acceptable salt, enantiomer, racemate or tautomer thereof.