Patent ID: 7595040
Filing Date: 2009-09-29
Classification: A61K,A61P,C07K

Abstract:
1. A purified and isolated synthetic human interferon-β protein analog, wherein, said protein analog differs in amino acid sequence from native human interferon-β, wherein native human interferon-β consists of the amino acid sequence set forth in SEQ ID NO:1, and wherein said protein analog differs in amino acid sequence from SEQ ID NO:1 at position 25, and optionally, at one or more positions selected from the group consisting of 1 and 17, numbered in accordance with SEQ ID NO:1; the asparagine at position 25 is deamidated, and, said protein analog exhibits a biological activity of native human interferon-β, wherein the biological activity is selected from the group consisting of inhibition of a virally-induced cellular cytopathic effect and an anti-proliferative effect.