Patent ID: 6610721
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of formula (I): whereinR1 is hydrogen or a functional group that can be converted to hydrogen in vivo, R2 is hydrogen, C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, halogen, cyano, trifluoromethyl, hydroxy, thiol or â€”NR5R6, wherein R5 and R6 independently are hydrogen or C1-6-alkyl, R3 and R4 independently are hydrogen or C1-6-alkyl, which is unsubstituted or substituted with aryl, which are unsubstituted or substituted with one or more substituents selected from nitro, â€”NR7R8, â€”S(&boxH;O)2NR7R8, â€”C(&boxH;O)NR7R8, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR7, C1-6-alkyl-carbonyl, â€”C(&boxH;NOR7)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, â€”C(&boxH;NOR7)C3-10-cycloalkyl, aryl-C1-6-alkyl, arylamino, aroyl, arylsulfonyl, â€”C(&boxH;NOR7)aryl, arylthio, and aryloxy, wherein R7 and R8 independently are hydrogen or C1-6-alkyl, m is 0, n is 1, 2, 3 or 4, X is a valence bond, p is 0, 1, 2 or 3, Y is â€”Oâ€”, q is 0, 1, 2 or 3, V is aryl or C3-10-cycloalkyl, which are unsubstituted or substituted with one or more substituents selected from nitro, â€”NR10R11, â€”S(&boxH;O)2NR10R11, â€”C(&boxH;O)NR10R11, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR10, C1-6-alkylcarbonyl, â€”C(&boxH;NOR10)C1-6-alkyl, oxo, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, â€”C(&boxH;NOR10)C3-10-cycloalkyl, arylamino, aroyl, arylsulfonyl, â€”C(&boxH;NOR10)aryl, and arylthio, wherein R10 and R11 independently are hydrogen or C1-6-alkyl, aryl-C1-6-alkyl, aryl or aryloxy, which are unsubstituted or substituted with one or more substituents selected from nitro, hydroxy, C1-6-alkyl, C1-6-alkoxy, cyano, trifluoromethyl, â€”OCF3, halogen C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, which are unsubstituted or substituted with one or more substituents selected from C3-10-cycloalkyl, and aryl, which are unsubstituted or substituted with one or more substituents selected from nitro, â€”NR12R13, â€”S(&boxH;O)2NR12R13, â€”C(&boxH;O)NR12R13, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR12, C1-6-alkylcarbonyl, â€”C(&boxH;NOR12)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, â€”C(&boxH;NOR12)C3-10-cycloalkyl, aryl-C1-6-alkyl, arylamino, aroyl, arylsulfonyl, â€”C(&boxH;NOR12)aryl, arylthio, and aryloxy, wherein R12 and R13 independently are hydrogen or C1-6-alkyl, or any stereoisomer or tautomeric form thereof or a mixture thereof or a pharmaceutically acceptable salt thereof.