Patent ID: 8895720
Filing Date: 2014-11-25
Classification: A61P,C12N,C12Q

Abstract:
1. An isolated nucleic acid molecule, wherein said nucleic acid molecule is a miRNA, a pre-miRNA or a DNA molecule encoding said pre-miRNA, which has a length of 18-26 nucleotides in the case of miRNA, wherein: (a) the sequence of the nucleic acid molecule comprises SEQ ID NO:11390 or its corresponding ribonucleotide sequence, or (b) the sequence of the nucleic acid molecule has at least 90% identity over 20 consecutive nucleotides with the miRNA sequence of (a), wherein said sequence comprises at least one modification selected from the group consisting of: a nucleotide analogue, a peptide nucleic acid a locked nucleic acid a backbone modified ribonucleotide or deoxyribonucleotide and a sugar modified ribonucleotide or deoxyribonucleotide.