Patent ID: 9067887
Filing Date: 2015-06-30
Classification: A61P,C07D

Abstract:
1. A compound represented by the formula (I) wherein X is a fluorine atom; R is a hydrogen atom or alkyl; R R R R (1) a fused heterocyclic group of the formula wherein X R R when X (2) a group of the formula wherein X R (3) a group of the formula wherein X X X R′ is a hydrogen atom or alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of substituted hydroxyl and amino, and R (4) a group of the formula wherein (5) 3-pyridyl optionally substituted by 1 or 2 substituents selected from the group consisting of (6) 4-pyridyl optionally substituted by a halogen atom, (7) 5-pyrimidinyl optionally substituted by 1 or 2 substituents selected from the group consisting of amino, alkylamino, dialkylamino and carboxy, (8) 2-indolyl, 3-indolyl, 5-indolyl, 6-indolyl, benzofuranyl, benzothiophenyl, benzoxazolyl or benzothiazolyl, each optionally substituted by 1 or 2 substituents selected from the group consisting of (9) a group of the formula wherein one of Y W is O, S, NH or N(R R R (10) a group of the formula wherein R R (11) a group of the formula wherein X X X X R R when X (12) a group of the formula wherein R (13) a group of the formula wherein R n is 0 or 1, R (14) a group of the formula wherein R (15) naphthyl or isochromenyl, (16) quinolyl or isoquinolyl, or their oxide derivatives, (17) a group of the formula (18) a group of the formula wherein U is O or S, and R (19) a group of the formula wherein R (20) a group of the formula wherein R or R (21) a group of the formula wherein R (22) a group of the formula or a salt thereof,