Patent ID: 6423723
Filing Date: 2002-07-23
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of Formula IX, and pharmaceutically acceptable addition salts thereof, whereinn=1; L is CH and M is CH or, if R11 and R12 together form an aromatic ring, C; R9 and R13 are each independently hydrogen, halogen, cyano, oxo, carboxy, formyl, nitro, amino, amidino, guanidino, C1-C5 alkyl or alkenyl or arylalkyl imino, azido, mercapto, carboxamido, hydroxy, hydroxyalkyl, alkylaryl, arylalkyl, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, C2-C8 acyl, C1-C8 alkylthio, arylalkylthio, arylthio, C1-C8 alkylsulfinyl, arylalkylsulfinyl, arylsulfinyl, C1-C8 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, C1-C6 N-alkyl carbamoyl, C2-C15 N,N-dialkylcarbamoyl, C1-C5 alkyl or alkenyl or arylalkyl ester, C1-C7 cycloalkyl, aroyl, aryloxy, benzyloxy, benzyloxy substituted with one or more substituents, aryl, aryl substituted with one or more substituents, or â€”NR6R7 or â€”(CH2)sNR6R7 where s is 1-6 and R6 and R7 are as defined in (b), below; R11 and R12 in combination are a fused ring or a fused ring substituted with one or more substituents; R1 is hydrogen, C1-C10 alkyl, C1-C10 alkyl substituted with one or more substituents, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more substituents, C2-C10 alkynyl, C2-C1 alkynyl substituted with one or more substituents, C1-C8 alkoxy, C1-C8 alkoxy substituted with one or more substituents, C2-C8 alkoxycarbonyl, C2-C8 alkoxycarbonyl substituted with one or more substituents, C1-C8 thioalkyl, C1-C8 thioalkyl substituted with one or more substituents, C2-C8 acyl, C2-C8 acyl substituted with one or more substituents, C2-C8 acyloxy, C2-C8 acyloxy substituted with one or more substituents, aryloxy, aryl, aryl substituted with one or more substituents, C3-C7 cycloalkyl, C3-C7 cycloalkyl substituted with one or more substituents; R2 is carbazolyl or carbazolyl substituted with one or more substituents; R5 is a substituted C6 heterocyclic ring with one oxygen; W is carbonyl (C&boxH;O), amido (NH(C&boxH;O)), amidoalkyl (NH(C&boxH;O)CH2â€”), imino (C&boxH;NH), thiocarbonyl (C&boxH;S), sulfonyl (SO2), methylene (CH2), or methylene substituted with one or more substituents; Z is carbonyl (C&boxH;O), amino (NH), imino (C&boxH;N), sulfonyl (SO2), or (C&boxH;O)NH; and the substituents are independently (a) halogen, cyano, oxo, carboxy, formyl, nitro, amino, amidino, guanidino, C1-C5 alkyl or alkenyl or arylalkyl imino, carbamoyl, azido, carboxamido, mercapto, hydroxy, hydroxyalkyl, alkylaryl, arylalkyl, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, aryloxycarbonyl, C2-C8 acyl, C1-C8 alkylthio, arylalkylthio, arylthio, C1-C8 alkylsulfinyl, arylalkylsulfinyl, arylsulfinyl, C1-8 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, C1-C6 N-alkyl carbamoyl, C2-C15 N,N-dialkylcarbamoyl, C3-C7 cycloalkyl, aroyl, aryloxy, arylalkyl ether, aryl, aryl fused to a cycloalkyl; or (b) NR6R7, where R6 and R7 are each independently hydrogen, cyano, oxo, carboxamido, amidino, C1-C8 hydroxyalkyl, C1-C3 alkylaryl, aryl-C1-C3 alkyl, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, aryloxycarbonyl, aryl-C1-C3 alkoxycarbonyl, C2-C8 acyl, C1-C8 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, aroyl, aryl, aryl fused to a cycloalkyl; â€ƒor R6 and R7 are taken together to form â€”CH2)mB(CH2)n where B is â€”C(H)(R8) â€”, â€”Oâ€”, â€”N(R8)â€”, or â€”S(O)râ€”, where m and n are independently 1 to 3, r is 0 to 2, and R8 is defined the same way as R6; or (c) â€”(CH2)sNR6R7 where s is 1-6 and R6 and R7 are as defined in section (b) of the definition of substituent, above.