Patent ID: 6897340
Filing Date: 2005-05-24
Classification: C07C

Abstract:
1. A reproducible process for preparation of sertraline hydrochloride Form II comprising the steps of: a) providing a solution of sertraline base, or a solution or slurry of sertraline mandelate, in an organic solvent; b) contacting the solution or the slurry with a flow of gaseous hydrogen chloride at a temperature within the range of from about 30° C. to about 60° C., during which time sertraline hydrochloride Form II forms, wherein the temperature is kept substantially constant during the gas flow; and c) filtering the sertraline hydrochloride Form II at a temperature of from about 30° C. to about 60° C. to obtain sertraline hydrochloride Form II containing less than about 1% sertraline hydrochloride Form I as measured wt/wt sertraline hydrochloride Form I/sertraline hydrochloride.