Patent ID: 6462072
Filing Date: 2002-10-08
Classification: A61P,C07D

Abstract:
A compound of formula II or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:A and B, taken together with the carbon atoms to which they are respectively attached, form a 5 membered saturated or unsaturated heterocyclic ring having one nitrogen heteroatom; R and R1 are independently C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, C3-C9 cycloalkyl, C3-C9 cycloalkenyl, or Ar, wherein said R and R1 are independently unsubstituted or substituted with one or more substituent(s) and the carbon atoms of said alkyl, alkenyl, cycloalkyl, and cycloalkenyl are independently unsubstituted or substituted with one or more heteroatom(s); R2 is C3-C9 cycloalkyl, C3-C9 cycloalkenyl or Ar, wherein said cycloalkyl, cycloalkenyl, or Ar is substituted with one or more substituent(s), and the carbon atoms of said cycloalkyl and cycloalkenyl are independently unsubstituted or substituted with one or more heteroatom(s); Ar is an aromatic or carbocyclic ring having an individual ring size of 5-9 members, or a mono-, bi- or tricyclic, heterocyclic ring having an individual ring size of 5-9 members, said heterocyclic ring containing one or more heteroatom(s) independently selected from the group consisting of O, S, SO, SO2, N, NH and NR; W is O, S, CH2 or H2; X is O or S; Y is O or S; and Z is O, NH or NR.