Patent ID: 7807845
Filing Date: 2010-10-05
Classification: A61P,C07D

Abstract:
1. A compound of the formula: wherein: D′ is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkyl and aralkyl, and is optionally substituted by alkyl, halo, nitro, cyano, CF R20 is selected from the group consisting of H, alkyl, alkenyl and alkynyl; R21 is H or is selected from the group consisting of alkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl and heteroaryl, each optionally substituted by one or more halo, haloalkyl, hydroxy, alkoxy, aryloxy, cycloalkoxy, heteroaryloxy, cyano, nitro, alkylthio, arylthio, cycloalkylthio, amino, or mono- or dialkylamino, mono- or diarylamino, mono- or di-cycloalkylamino, mono- or di-heteroarylamino, alkanoyl, cycloalkanoyl, aroyl, heteroaroyl, carboxamido, mono- or dialkylcarboxamido, mono- or diarylcarboxamido, sulfonamido, mono- or dialkylsulfonamido, mono- or diarylsulfonamido, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, aiylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, heteroarylsulfinyl or heteroarylsulfonyl; or R21 and R31 together with the nitrogen atom to which they are attached, form a 3-8 membered unsubstituted or substituted heterocyclyl or heteroaryl ring; or R20 and R21 together form a 5-8 membered unsubstituted or substituted heterocyclyl or heteroaryl ring; R31 is hydrogen, or is selected from the group consisting of alkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl and heteroaryl, each optionally substituted by one or more halo, haloalkyl, hydroxy, hydroxyalkyl, R32, —COH, —COR32, —CO2H, —COOR32, —CONH2, —CONHR32, —CONR32R32, —OR32 OCOR32, —OCONHR32, OCONR32R32, cyano, nitro, amino, NHR32, NR32R32, NHCONH2, NHCONHR32, NHCONR32R32, NR32CONH2, NR32CONHR32, NR32CONR32R32, NHCOOR32, NR32COOR32, SR32, SO where each R32 is independently alkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl and heteroaryl; and R30 is selected from the group consisting of hydrogen, OH and NHR, where R is H or is selected from the group consisting of alkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo and heteroaryl; optionally substituted by halo, hydroxy, alkoxy, aryloxy, cycloalkoxy, heteroaryloxy, cyano, nitro, alkylthio, arylthio, cycloalkylthio, amino, or mono- or dialkylamino, mono- or diarylamino, mono- or di-cycloalkylamino, mono- or di-heteroarylamino, alkanoyl, cycloalkanoyl, aroyl, heteroaroyl, carboxamido, mono- or dialkylcarboxamido, mono- or diarylcarboxamido, sulfonamido, mono- or dialkylsulfonarnido, mono- or diarylsulfonamido, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, arylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, heteroarylsulfinyl, heteroarylsulfonyl; and the pharmaceutically acceptable salts thereof and stereoisomers thereof.