Patent ID: 7125558
Filing Date: 2006-10-24
Classification: A61K,C08G,C08L

Abstract:
1. A process for preparing a bis-activated polyethylene glycol having the formula: wherein n is an integer between 4 and 800; Y is selected from the group consisting of a halide group, a mesyl group, a tosyl group, an imidazolyl group, an N-hydroxy-succinimidyl group, a phenoxyl group, and a substituted phenoxyl group; and Q is selected from the group consisting of SO the process consisting essentially of reacting under stoichiometric conditions a polyethylene glycol having the formula: wherein n is an integer between 4 and 800; in the presence of a solvent and an aromatic nitrogen-containing heterocyclic base having the formula: wherein (NR R c is 1 or 2; to produce said bis-activated polyethylene glycol.