Patent ID: 8440200
Filing Date: 2013-05-14
Classification: A61K,C07K,Y10S

Abstract:
1. A method for desensitization of a mammal suffering from IgE mediated allergy, the method comprising the step of administering to the mammal a therapeutically effective amount of an immunogenic and hypoallergenic composition which comprises a modified Phl p 6 molecule, wherein the modified Phl p 6 molecule is a C-terminal truncated form of Phl p 6 polypeptide, the Phl p 6 polypeptide consisting of amino acids 29-138 of SEQ ID NO: 15, the C-terminal truncation making the modified Phl p6 molecule exhibit reduced IgE binding capacity as compared with the Phl p 6 polypeptide, the modified Phl p 6 molecule being capable of raising an IgG immune response in the mammal, and a pharmaceutically acceptable carrier.