Patent ID: 6835712
Filing Date: 2004-12-28
Classification: A61K,C07C,C07D,C07K,C12N

Abstract:
A spermine:peptide-based surfactant compound having the general structure of formula (I): wherein R1 and R3 are hydrogen and R2 and R4, which may be the same or different, are peptide groups formed from one or more amino acids linked together, in a linear or branched manner, by amine (CONH) bonds and further linked to the spermine backbone by amide bonds, having the general formula (II): wherein p1 is 0 to 5 and p2 is 1 to 5; and the values for p3 and p4, which may be the same or different, are from 0 to 5;A1, A3 and A4, which may be the same or different, are amino acids selected from the group consisting of serine, lysine, ornithine, threonine, histidine, cysteine, arginine and tyrosine; andA2 is an amino acid selected from the group consisting of lysine, ornithine and histidine;and R5 and R6 are saturated or unsaturated hydrocarbyl groups having up to 24 carbon atoms and linked to the spermine backbone by an amide or an amine (NCH2) linkage;orwhere R1 and R3 are hydrogen, R2 and R4, which may be the same or different are saturated or unsaturated hydrocarbyl groups having up to 24 carbon atoms and linked to the spermine backbone by amide or amine bonds, and R5 and R6, which may be the same or different, are peptide groups of formula (II) linked to the spermine backbone by amide bonds;andpharmaceutically acceptable salts thereof.