Patent ID: 6600016
Filing Date: 2003-07-29
Classification: C07K

Abstract:
A multifunctionalized solid support for the solid support synthesis of at least two different compounds, said solid support having the structure: wherein P is a resin backbone, T is a diamino acid moiety template having at least three attachment points, X is a covalent bonding entity for attachment of T to P and L1 and L2 are independently different benzyl linker moieties having the formula: wherein Z is selected from the group consisting of a covalent bond, O, â€”C(O)â€”, C1-6 alkylene, C5-10 aryl, carbonylC1-6alkylene, carbonylC1-6alkyleneoxy, carbonyl C5-10 aryl and carbonyl C5-10 heteroaryl, said alkylene, aryl and heteroaryl groups being substituted with H or C1-3 alkyl; R1 and R2 are independently selected from the group consisting of H, nitro, halo and C1-6alkoxy; R3 and R4 are independently selected from the group consisting of H, C1-6 alkyl, C5-10 aryl and C5-10 heteroaryl, said alkyl, aryl and heteroaryl groups being substituted with H, C1-3 alkyl or C1-3 alkoxy; and W is selected from the group consisting of OH, NH2 and NHpg where pg is a protecting group.