Patent ID: 6624176
Filing Date: 2003-09-23
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is â€”NH(CH2)2OH or â€”NR3C(O) R4; R2 is methyl or chloro; R3 is hydrogen or methyl; R4 is lower alkyl or lower cycloalkyl; R is hydrogen or â€”(CH2)2OH; and n is 1 or 2, provided that when the compound has the formula IB, R1 is not 4-hydroxy-piperidine or 3-hydroxy-pyrrolidine, further provided that when the compound has the formula IB and R2 is methyl, R1 is not 2,3-dihydro-[1,4]oxazin-4-yl or imidazol-1-yl, further provided that when the compound has the formula IA and R2 is methyl, R1 is not [1,2,4]triazol-1-yl, or a pharmaceutically acceptable acid addition salt thereof.