Patent ID: 6039979
Filing Date: 2000-03-21
Classification: A61K

Abstract:
Multiparticulate pharmaceutical form with delayed and pulsed release of the active ingredient, enabling to obtain the onset of the availability of the active ingredient within 4 to 8 hours after the ingestion of the pharmaceutical form, and then to progressive release of the totality of the active ingredient within the 8 to 20 following hours, the said multiparticulate pharmaceutical form which is free of organic acid, comprising medicinal spheroids including each a neutral spherical core enveloped by a first coating based on a mixture of at least one hydrosoluble polymer and of at least one non hydrosoluble polymer throughout which are uniformly distributed the constitutive particles of an active ingredient, the cores coated with the first coating comprising a second coating based on at least two pH independent polymers presenting rates of permeability different from one another with respect to the gastric and intestinal mediums.