Patent ID: 7700771
Filing Date: 2010-04-20
Classification: A61P,C07D

Abstract:
1. A compound of the formula [I]: wherein R (a) hydrogen, (b) a halogen, (c) nitro, (d) an alkyl optionally substituted by 1 to 3 substituent(s) selected from a halogen, hydroxy and amino, (e) an alkoxy optionally substituted by 1 to 3 substituent(s) selected from hydroxy and amino, (f) an amino optionally substituted by 1 or 2 substituent(s) selected from (i) an alkyl which may be substituted by 1 to 3 groups independently selected from the group consisting of an alkoxy, amino and carboxy, and (ii) an alkanoyl, (g) a carbamoyl optionally substituted by alkyl(s), (h) hydroxy or (i) cyano, p is 1 or 2, provided that when p is 2, two R Z is —NH—, Ring A is a ring selected from the following formulae: R R (a) hydrogen, (b) an alkyl optionally substituted by 1 to 3 substituent(s) selected from (i) alkynyl, (ii) cyano, (iii) alkoxy, (iv) hydroxy, (v) amino which may be substituted by 1 or 2 substituent(s) independently selected from the group consisting of alkyl, alkanoyl and alkylsulfonyl, (vi) carboxy, (vii) alkoxycarbonyl, (viii) carbamoyl which may be substituted by 1 or 2 alkyl(s), (ix) phenyl and (x) naphthyl, (c) an alkoxyalkyl, (d) a cycloalkyl optionally substituted by 1 to 3 substituent(s) selected from (1) hydroxy, (2) alkoxy which may be substituted by 1 to 3 alkoxy(s), (3) amino which may be substituted by the same or different 1 or 2 group(s) independently selected from the groups consisting of (i) alkyl, (ii) alkanoyl, (iii) alkoxycarbonyl, (iv) carbamoyl which may be substituted by 1 or 2 alkyl(s), and (v) alkylsulfonyl, (4) carboxy, (5) alkyl which may be substituted by a group selected from the group consisting of hydroxy, alkoxy and amino, (6) carbamoyl which may be substituted by alkyl(s), (e) a phenyl optionally substituted by 1 to 3 group(s) selected from (1) a halogen, (2) nitro, (3) alkyl which may be substituted by the same or different 1 to 3 group(s) selected from the group consisting of a halogen, hydroxy, amino, carboxy and phenylsulfonyl, (4) alkenyl, (5) cyano, (6) hydroxy, (7) alkoxy which may be substituted by the same or different 1 to 3 group(s) independently selected from the group consisting of a halogen, carboxy, alkoxycarbonyl, carbamoyl, phenyl and morpholinylcarbonyl, (8) amino which may be substituted by the same or different 1 or 2 group(s) independently selected from the groups of (i) alkyl, (ii) alkanoyl, (iii) carbamoyl which may be substituted by the same or different 1 or 2 group(s) independently selected from the group consisting of alkyl and cycloalkyl, and (iv) alkylsulfonyl, (9) alkanoyl, (10) carboxy, (11) alkoxycarbonyl, (12) carbamoyl which may be substituted by one or two group(s) which may be the same or different from each other independently selected from the groups consisting of (i) alkyl which may be substituted by 1 to 3 hydroxy(s), and (ii) cycloalkyl, (13) alkylthio, (14) alkylsulfinyl, (15) alkylsulfonyl, (16) phenyl, (17) tetrazolyl, (18) heterocyclic group-substituted carbonyl, whose heterocyclic group is selected from the group consisting of furyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiapyranyl, thienyl, tetrahydrothienyl, thiazolyl, isothiazolyl, tetrahydroisothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, pyrrolyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyridyl, pyridazinyl, pyrimidinyl, hexahydropyrimidinyl, pyrazinyl, triazinyl, piperidyl, pyrazolyl, piperazinyl, morpholinyl, dioxanyl, imidazolyl, triazolyl, pyrazolinyl, thiazinyl, and tetrahydrothiazinyl, and the heterocyclic group may be substituted by the same or different 1 to 3 group(s) independently selected from the group consisting of alkyl and alkoxycarbonyl, or (f) a heterocyclic group selected from the group consisting of furyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiapyranyl, thienyl, tetrahydrothienyl, thiazolyl, isothiazolyl, tetrahydroisothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, pyrrolyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyridyl, pyridazinyl, pyrimidinyl, hexahydropyrimidinyl, pyrazinyl, triazinyl, piperidyl, pyrazolyl, piperazinyl, morpholinyl, dioxanyl, imidazolyl, triazolyl, pyrazolinyl, thiazinyl, and tetrahydrothiazinyl, and which is optionally substituted by 1 to 3 substituent(s) selected from (1) a halogen, (2) nitro, (3) alkyl which may be substituted by a group selected from the group consisting of (i) hydroxy, (ii) alkoxy, (iii) carbamoyl optionally substituted by alkyl, and (iv) carboxy, (4) cyano, (5) hydroxy, (6) amino, (7) alkanoyl, (8) carboxy, (9) alkoxycarbonyl, (10) carbamoyl which may be substituted by 1 or 2 alkyl(s), (11) alkylsulfonyl, (12) phenyl and (13) oxo, n is 0 or an integer of 1 to 4, Q Ring B is a cyclohexyl ring, X is N, Y is a single bond, SO Ring C is a C wherein R or a pharmaceutically acceptable salt thereof.