Patent ID: 9034591
Filing Date: 2015-05-19
Classification: C07K,G01N

Abstract:
1. An isolated monoclonal antibody, or binding fragment thereof, specific to an epitope located on a first order immune complex, the first order immune complex consisting of a first antibody, or binding fragment thereof, bound to BNP, to proBNP, or to a fragment of BNP or proBNP, the first antibody being specific for a region consisting of the amino acid sequence wherein the isolated monoclonal antibody, or binding fragment thereof, does not recognize free BNP, free proBNP, a fragment of BNP or proBNP, or free first antibody, or a binding fragment thereof, or which recognizes them with 10-fold or less affinity than it recognizes the first order immune complex, wherein the isolated monoclonal antibody or binding fragment thereof is Ab -BNP2, Ab-BNP4, or a binding fragment thereof.