Patent ID: 8461312
Filing Date: 2013-06-11
Classification: C07B,C07C,C07D,C07H

Abstract:
1. A method for the production of the compound of the formula I in which R2, R2′, R3, R3′, R4, R4′, R5, R5′, independently of one another, are H, Cl, Br, I, OH, —(CH where always at least one of the radicals R2, R2′, R3, R3′, R4, R4′, R5, R5′ has the meaning —O—(CH R6 is H, OH, (C n is 2, 3, 4, 5, 6; m is 1, 2, 3, 4, 5, 6; p is 0, 1, 2; which comprises G) reacting the compound of the formula 5 with a compound of the formula 8 to give the compound of the formula 10 and then in a further process step H) reacting the compound of the formula 10 in the presence of BF and then in a further process step I) reacting the compound of the formula 11 in the presence of H and then in a further process step J) reacting the compound of the formula 12 in the presence of TEMPO (2,2,6,6-tetramethylpiperidinyloxyl) to give compound 13 and then in a further process step K) reacting the compound of the formula 13 in the presence of tBuOK in THF to give compound 15/15A and then in a further process step L) isolating the compound of the formula 15 and then in a further process step M) reacting the compound of the formula 15 with the help of H and then in a further process step N) reacting the compound of the formula 16 in the presence of HNMe and then in a further process step O) isolating the compound of the formula 17 and then in a further process step P) reacting the compound 17 with the compound 18, in which the radicals have the meanings given above to give a compound of the formula 19 and then optionally in a further process step Q) reacting the compound of the formula of the formula 19, in which the radicals have the meanings given above, to give a compound of the formula 20, in which the radicals have the meanings given above, where any protective groups present are cleaved off, and then in then optionally in a further process step R) reacting the compound of the formula 20, in which the radicals have the meanings given above, to give a compound of the formula Ia, in which the radicals have the meanings given above, as a result of which the substituents R2, R2′, R3, R3′, R4, R4′, R5, R5′ from formula 20 can be exchanged.