Patent ID: 6426184
Filing Date: 2002-07-30
Classification: B01J,B82Y,C07B,C07H,C07K,C40B,G03F

Abstract:
A method of attaching monomers at specific reaction sites on a substrate, said specific reaction sites containing one or more non-photolabile protected initiating moieties, the method comprising:a) contacting said substrate with a liquid solution comprising one or more photo-reagent precursors, said precursors selected from the group consisting of acid and base precursors, such that said liquid solution is in contact with said initiating moieties; b) isolating said specific reaction sites; c) irradiating a selected number of the isolated reaction sites to produce, in situ, at least one photo-generated reagent without the formation of a polymeric coating layer, thereby directly deprotecting the initiating moieties at the irradiated reaction sites so as to create deprotected initiating moieties; and d) contacting said substrate with a first monomer, said first monomer comprising an unprotected reactive site and a protected reactive site, under conditions such that said unprotected reactive site of said monomer couples with said deprotected initiating moieties so as to create an attached first monomer.