Patent ID: 6830894
Filing Date: 2004-12-14
Classification: A61K,A61P,C07K

Abstract:
A method for inhibiting claudin-mediated cell adhesion, comprising contacting a claudin-expressing cell with a cell adhesion modulating agent that:(a) comprises an acetylated claudin CAR sequence selected from the group consisting of WKIYSYAG (SEQ ID NO: 34), WRIYSYAG (SEQ ID NO: 485), WRTSSYVG (SEQ ID NO: 42), WRVSAFIG (SEQ ID NO: 58), WRVTAFIG (SEQ ID NO: 50), WQVTAFLD (SEQ ID NO: 277), WQMSSYAG (SEQ ID NO: 394), WRVSAFIE (SEQ ID NO: 450), and WKVTAFIG (SEQ ID NO: 335), said claudin CAR sequence being present in a naturally occurring claudin; and (b) consists of no more than 50 consecutive amino acid residues present within the claudin.