Patent ID: 6251917
Filing Date: 2001-06-26
Classification: A61P,C07C,C07D

Abstract:
A benzamidoaldehyde of the formula I ##STR91##or a tautomeric or isomeric form or physiologically acceptable salt thereof, where:R.sup.1 is phenyl, naphthalene, quinoline, isoquinoline, tetrahydroquinoline, tetrahydroisoquinoline, pyridine, pyrimidine, pyrazine, pyridazine, quinazoline, quinoxaline, thiophene, benzothiophene, benzofuran, furan or indole, where the aromatic and heteroaromatic rings may be substituted by up to three radicals R.sup.4,R.sup.2 is hydrogen, chlorine, bromine, fluorine, phenyl with or without substitution by a C.sub.1 -C.sub.4 -hydrocarbon radical, --NHCO-C.sub.1 -C.sub.4 -alkyl, --NHCOPh, --NHCO-naphthyl, --NHSO.sub.2 -C.sub.1-4 -alkyl, --COO-C.sub.1-4 -alkyl, --CONH.sub.2, COOH, --O-C.sub.1-4 -alkyl, --CO--NH-C.sub.1-4 -alkyl, NO.sub.2 or NH.sub.2,R.sup.3 is a C.sub.1 -C.sub.6 -hydrocarbon radical, which may also carry a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indolyl, phenyl, pyridine or naphthyl ring, it being possible for the rings in turn to be substituted by one or two radicals R.sup.4, or is an --SCH.sub.3 radical,R.sup.4 is C.sub.1 -C.sub.4 -alkyl, --O-C.sub.1 -C.sub.4 -alkyl, OH, Cl, F, Br, I, CF.sub.3, NO.sub.2, NH.sub.2, CN, COOH, COO-C.sub.1 -C.sub.4 -alkyl, --NHCO-C.sub.1 -C.sub.4 -alkyl, --NHCOPh, --NHSO.sub.2 -C.sub.1 -C.sub.4 -alkyl, --NHSO.sub.2 -Ph, --(CH.sub.2).sub.n --NR.sup.5 R.sup.6 (R.sup.5 and R.sup.6 are identical or different and are each hydrogen, C.sub.1-4 -alkyl or together are a ring), --SO.sub.2 -C.sub.1 -C.sub.4 -alkyl or --SO.sub.2 Ph,X is --(CH.sub.2).sub.m --, --(CH.sub.2).sub.m --O--(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --S--(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --SO--(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --SO.sub.2 --(CH.sub.2).sub.o --, --CH.dbd.CH--, --C.ident.C--, --CO--CH.dbd.CH--, --CH.dbd.CH--CO--, --(CH.sub.2).sub.m --CO--(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --NR.sup.5 CO--(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --CONR.sup.5 --(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --NHSO.sub.2 --(CH.sub.2).sub.o --, --(CH.sub.2).sub.m --SO.sub.2 NH--(CH.sub.2).sub.o --, NH--CO--CH.dbd.CH--, --CH.dbd.CH--CO--NH-- orn is the number 1 or 2,m is the number 0, 1, 2, 3 or 4, except that when X is --(CH.sub.2).sub.m --, m is the number 1, 2, 3 or 4, ando is the nurmber 0, 1, 2, 3 or 4, except that when R.sup.1 is phenyl and X is --O--(CH.sub.2).sub.o --, o is the number 1, 2, 3 or 4.