Patent ID: 6617350
Filing Date: 2003-09-09
Classification: A61P,C07C,C07D,C07F

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:Eâ€² is â€”SO2â€”; A is â€”R1â€”Ht; R1 is â€”Oâ€”C(O)â€”; each Ht is independently a 5-7 membered saturated or unsaturated heterocycle, containing one or more oxygen atoms; wherein said heterocycle is optionally fused to Q; and wherein said Ht is optionally substituted with one or more substituents independently selected from oxo, â€”OR2, SR2, â€”R2, â€”N(R2)(R2), â€”R2â€”OH, â€”CN, â€”CO2R2, â€”C(O)â€”N(R2)2, â€”S(O)2â€”N(R2)2, â€”N(R2)â€”C(O)â€”R2, â€”N(R2)â€”C(O)Oâ€”R2, â€”C(O)â€”R2, â€”S(O)nâ€”R2, â€”OCF3, â€”S(O)nâ€”Q, methylenedioxy, â€”N(R2)â€”S(O)2(R2), halo, â€”CF3, â€”NO2, Q, or â€”OQ; each Q is independently selected from a 3-7 membered saturated, partially saturated or unsaturated carbocyclic ring system; or a 5-7 membered saturated, partially saturated or unsaturated heterocyclic ring containing one or more heteroatoms selected from O, N, or S; wherein Q is optionally substituted with one or more groups selected from oxo, â€”OR2, â€”R2, â€”SO2R2, â€”SO2â€”N(R2)2, â€”N(R2)2, â€”N(R2)â€”C(O)â€”R2, â€”R2â€”OH, â€”CN, â€”CO2R2, â€”C(O)â€”N(R2)2, halo, â€”CF3; each R2 is independently selected from H, or C1-C4 alkyl; and wherein said alkyl, when not a substituent of Q, is optionally substituted with Q or â€”OR3; wherein when said R2 is an â€”OR3 substituted moiety, said R3 in â€”OR3 may not be â€”OR2 substituted; B is absent; each x is independently 0 or 1; each R3 is independently selected from H, Ht, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl or C5-C6 cycloalkenyl; wherein any member of said R3, except H, is optionally substituted with one or more substituents selected from â€”OR2, â€”C(O)â€”NHâ€”R2, â€”S(O)nâ€”N(R2)(R2), â€”N(R2)2, â€”N(R2)â€”C(O)â€”O(R2), â€”N(R2)â€”C(O)â€”N(R2), â€”N(R2)â€”C(O)â€”(R2), Ht, â€”CN, â€”SR2, â€”CO2R2, or NR2â€”C(O)â€”R2; each n is independently 1 or 2; G, when present, is selected from H, R7 or C1-C4 alkyl, or, when G is C1-C4 alkyl, G and R7 are optionally bound to one another either directly or through a C1-C3 linker to form a heterocyclic ring; or when G is not present, the nitrogen to which G is attached is bound directly to the R7 group in â€”OR7 with the concomitant displacement of one â€”ZM group from R7; D is selected from Q; C1-C6 alkyl optionally substituted with one or more groups selected from C3-C6 cycloalkyl, â€”OR2, â€”Sâ€”Ht, â€”R3, â€”Oâ€”Q or Q; C2-C4 alkenyl optionally substituted with one or more groups selected from â€”OR2, â€”Sâ€”Ht, â€”R3, â€”Oâ€”Q or Q; C3-C6 cycloalkyl optionally substituted with or fused to Q; or C5-C6 cycloalkenyl optionally substituted with or fused to Q; Dâ€² is selected from C1-C15 alkyl, C2-C15 alkenyl or C2-C15 alkynyl, each of which contains one or more substituents selected from oxo, halo, â€”CF3, â€”OCF3, â€”NO2, azido, â€”SH, â€”SR3, â€”N(R3)â€”N(R3)2, â€”Oâ€”N(R3)2, â€”(R3)Nâ€”Oâ€”(R3), â€”N(R3)2, â€”CN, â€”CO2R3, â€”C(O)â€”N(R3)2, â€”S(O)nâ€”N(R3)2, â€”N(R3)â€”C(O)â€”R3, â€”N(R3)â€”C(O)â€”N(R3)2, â€”N(R3)â€”C(O)â€”S(R3), â€”C(O)â€”R3, â€”S(O)nâ€”R3, â€”N(R3)â€”S(O)n(R3), â€”N(R3)â€”S(O)nâ€”N(R3)2, â€”Sâ€”NR3â€”C(O)R3, â€”C(S)N(R3)2, â€”C(S)R3, â€”NR3â€”C(O)OR3, â€”Oâ€”C(O)OR3, â€”Oâ€”C(O)N(R3)2, â€”NR3â€”C(S)R3, &boxH;Nâ€”OH, &boxH;Nâ€”OR3, &boxH;Nâ€”N(R3)2, &boxH;NR3, &boxH;NNR3C(O)N(R3)2, &boxH;NNR3C(O)OR3, &boxH;NNR3S(O)nâ€”N(R3)2, â€”NR3â€”C(S)OR3, â€”NR3â€”C(S)N(R3)2, â€”NR3â€”C[&boxH;N(R3)]â€”N(R3)2, â€”N(R3)â€”C[&boxH;Nâ€”NO2]â€”N(R3)2, â€”N(R3)â€”C[&boxH;Nâ€”NO2]â€”OR3, â€”N(R3)â€”C[&boxH;Nâ€”CN]â€”OR3, â€”N(R3)â€”C[&boxH;Nâ€”CN]â€”(R3)2, â€”OC(O)R3, â€”OC(S)R3, â€”OC(O)N(R3)2, â€”C(O)N(R3)â€”N(R3)2, â€”Oâ€”C(O)N(R3)â€”N(R3)2, Oâ€”C(O)N(OR3)(R3), N(R3)â€”N(R3)C(O)R3, N(R3)â€”OC(O)R3, N(R3)â€”OC(O)R3, N(R3)â€”OC(O)R3, â€”OC(S)N(R3)2, â€”OC(S)N(R3)(R3), or PO3â€”R3; E is selected from C6-C14 aryl; C3-C6 saturated carbocycle optionally substituted with one or more groups selected from R4 or Ht; or C5-C6 unsaturated carbocycle optionally substituted with one or more groups selected from R4 or Ht; each R4 is independently selected from â€”OR2, â€”OR3, â€”SR2, â€”SOR2, â€”SO2R2, â€”CO2R2, â€”C(O)â€”NHR2, â€”C(O)â€”N(R2)2, â€”C(O)â€”NR2(OR2), â€”S(O)2â€”NHR2, halo, â€”NR2â€”C(O)â€”R2, â€”N(R2)2 or â€”CN; each R7 is hydrogen.