Patent ID: 8603990
Filing Date: 2013-12-10
Classification: A61K,A61P

Abstract:
1. A polymeric drug having a main chain and a graft chain said graft being bound to the main chain by a bond, which is stable in the body or by a bond cleavable in the body or by a combination thereof, wherein the molecular weight of the main chain range is from 10,000 to 50,000 g/mol, and the molecular weight of the grafts range is from 5,000 to 50,000 g/mol, and wherein the total molecular weight of the grafted polymer ranges from 50,000 to 400,000 g/mol; and wherein the polymeric drug is of structure 1a: Wherein Dox is doxorubicin, n ranges from 40 to 335, m from 0 to 85, p from 1 to 20, q from 1 to 10 and r from 34 to 350; SP1 is an aminoacyl, glycyl, glycylglycyl, B-alanyl, 6-aminohexanoyl (AH) or 4-aminobenzoyl or a combined acyl derivative from the oligopeptides GlyPheGly (SEQ ID. NO. 2), GlyLeuGly (SEQ ID. NO. 1), GlyLeuPheGly (SEQ ID. NO. 4) or GLyPheLeuGly (SEQ ID. N). 3) or any combination thereof.