Patent ID: 8242137
Filing Date: 2012-08-14
Classification: A61K,A61M,A61P,C07B,C07D

Abstract:
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, about 6 weight percent of water, and a crystalline salt of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester and phosphoric acid in a 1:2 molar ratio in a micronized form and characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 15.0±0.2, 19.4±0.2, 21.6±0.2, and 23.7±0.2 and characterized by a differential scanning calorimetry trace which shows a maximum endothermic heat flow at about 154.5° C.