Patent ID: 8658799
Filing Date: 2014-02-25
Classification: A61P,C07D

Abstract:
1. A process for preparing esomeprazole sodium salt modification C, the process comprising the steps of: i) suspending esomeprazole potassium salt in toluene and adjusting the pH by adding about 1 molar equivalent of hydrochloric acid or acetic acid as an aqueous solution thereby forming a toluene phase and an aqueous phase; ii) separating the phases and adding to the separated toluene phase a solvent consisting of methanol; iii) adding to the solution formed in step ii) about 1 molar equivalent of a sodium salt of a base B as an aqueous solution; iv) allowing esomeprazole sodium salt modification C to crystallize; and v) isolating the formed esomeprazole sodium salt modification C.