Patent ID: 6608207
Filing Date: 2003-08-19
Classification: C07D

Abstract:
A process for producing a substituted alkylamine derivative represented by the following formula (3): wherein X is a halogen atom, an alkyl group, an alkoxy group, a cyano group or a nitro group; n is an integer of 1 to 4; and R1 and R2 are each independently a hydrogen atom or a phenyl group-substituted or unsubstituted alkyl group and may together form a 5- or 6-membered ring, which process comprises adding a salt of a 2-aminothiophenol derivative represented by the following formula (1): wherein X and n have the same definitions as given above, into an acid while controlling the pH of the system to 6 or less thereby converting the salt into a free 2-aminothiophenol derivative of the formula (1) and then reacting the 2-aminothiophenol derivative with an amino acid-N-carboxyanhydride represented by the following formula (2): wherein R1 and R2 each have the same definitions as given above.