Patent ID: 7993878
Filing Date: 2011-08-09
Classification: A61K,A61P,C07K

Abstract:
1. A polynucleotide construct that encodes an IL-1β binding molecule or antigen-binding fragment thereof comprising, a) a heavy chain variable domain comprising amino acids 20-137 of the amino acid sequence set forth as SEQ ID NO:1; b) a light chain variable domain comprising amino acids 20-126 of the amino acid sequence set forth as SEQ ID NO:2; c) the three CDRs of the amino acid sequence set forth as SEQ ID NO:1 and the three CDRs of the amino acid sequence set forth as SEQ ID NO:2; or d) a heavy chain variable domain comprising amino acids 20-137 of the amino acid sequence set forth as SEQ ID NO:1 and a light chain variable domain comprising amino acids 20-126 of the amino acid sequence set forth as SEQ ID NO:2.