Patent ID: 6465486
Filing Date: 2002-10-15
Classification: A61K,C07D

Abstract:
A Compound which is an &agr;2-adrenoceptor agonist of the formula: wheren is 0, 1, 2; X is independently selected from the group consisting of C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, â€”SO2NH2, nitro, and two adjacent X are optionally fused to form the moiety: â€ƒwhereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed; Y is independently selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, trifluoromethyl and phenyl; and Z is independently selected from the group consisting of hydroxy, C1-4alkyl, bromine, chlorine, iodine, trifluoromethyl, C1-4alkoxy, â€”SO2NH2 and nitro with the proviso that where n is O, X must be present and X must be said fused moiety, and with the proviso, that where n is 1 or 2, then Y cannot be phenyl.