Patent ID: 8148084
Filing Date: 2012-04-03
Classification: A61K,C07K,G01N

Abstract:
1. A method of detecting the presence of autoantibodies to myelin oligodendrocyte glycoprotein (MOG) in a subject, the method comprising: obtaining a sample comprising serum or CSF from the subject; contacting the sample with a multimeric polypeptide, wherein the multimeric polypeptide comprises two or more fusion polypeptides comprising under conditions that allow binding of the multimeric polypeptide to antibodies present in the sample, if any, to thereby form multimeric polypeptide/antibody complexes; and detecting the presence of said multimeric polypeptide/antibody complexes in the sample, wherein the presence of multimeric polypeptide/antibody complexes in the sample indicates the presence of autoantibodies to MOG in the subject.