Patent ID: 8734794
Filing Date: 2014-05-27
Classification: A61K,A61P,C07K

Abstract:
1. A neutralising antibody or an antigen binding portion thereof comprising a light chain variable domain comprising the amino acid sequence of SEQ ID NO: 1 or a sequence which has at least 90% amino acid sequence identity with SEQ ID NO: 1 and a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:4 or a sequence which has at least 90% amino acid sequence identity with SEQ ID NO:4, wherein the antibody or antigen binding portion specifically binds to Toll-like Receptor 2 (TLR2) and wherein the antibody or antigen binding portion antagonises TLR2 independently of binding of the antibody or antigen binding portion to CD32, and wherein the light chain variable domain comprises CDR1, CDR2 and CDR3 of SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9, respectively, and the heavy chain variable domain comprises CDR1, CDR2 and CDR3 of SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12, respectively.