Patent ID: 8633301
Filing Date: 2014-01-21
Classification: A61K,A61P

Abstract:
1. A pharmaceutical combination comprising an antibody specifically recognizing CD38 and at least vincristine, wherein said antibody is capable of killing a CD38 + cell by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC); wherein said antibody comprises at least one heavy chain comprising three sequential complementarity-determining regions (CDRs) comprising the amino acid sequences of SEQ ID Nos: 13, 81, and 15, and at least one light chain comprising three sequential complemetarity-determining regions (CDRS) comprising the amino acid sequences of SEQ ID NOS: 16, 17, and 18; and wherein the antibody and vincristine constituents of the combination are physically separate.