Patent ID: 6465615
Filing Date: 2002-10-15
Classification: C07K

Abstract:
A particulate crystalline lisinopril monohydrate formed by the process consisting of:(a) dissolving 1-(N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl)-L-proline (â€œlisinoprilâ€ ) in water to form a solution; (b) adding isobutanol to the solution of step (a) in an amount and under conditions effective to induce crystallisation of the lisinopril monohydrate; (c) isolating the crystals formed in step (b); (d) drying the crystals at a temperature not to exceed 80Â° C. for a time and under conditions effective to produce particulate crystalline lisinopril monohydrate; and (e) recovering the particulate crystalline lisinopril monohydrate.