Patent ID: 7148239
Filing Date: 2006-12-12
Classification: A61P,C07C,C07D

Abstract:
1. A method of increasing expression of a molecular chaperone by a eukaryotic cell comprising: treating a eukaryotic cell of a living mammalian organism that is exposed to a physiological stress accompanying allergic diseases, immune diseases, autoimmune diseases, diseases of viral or bacterial origin, tumorous, skin and/or mucous diseases, epithelial disease of renal tubulus, atherosclerosis, coronarial disease, pulmonary hypertonia, cerebrovascular ischemia, stroke, or traumatic head injury, with an effective amount of a chemical compound to increase the expression of the molecular chaperone by the cell beyond the amount induced by the physiological stress, wherein the chemical compound is selected from hydroxylamine derivatives represented by formula (II), or a salt thereof or any optically active streoisomer thereof, wherein A is an alkyl, substituted alkyl, aralkyl, aralkyl substituted in the aryl and/or alkyl moiety, aryl, substituted aryl, heteroaryl or substituted heteroaryl group, Z is a covalent bond, oxygen or ═NR R is alkyl or substituted alkyl, and X is oxygen, an imino or substituted imino group, and R′ is hydrogen, an alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, aralkyl substituted in the aryl or alkyl moiety, acyl or substituted acyl group.