Patent ID: 6166056
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A compound of Formula I: or pharmaceutical acceptable salts thereof wherein:X is NR.sub.1 ;R.sub.1 isa) H,b) C.sub.1 6 alkyl, optionally substituted with one or more OH, CN, or halo,c) --(CH.sub.2).sub.h -aryl,d) --COR.sub.1-1,e) --COOR.sub.1-2,f) --CO--(CH.sub.2).sub.h --COR.sub.1-1,g) --SO.sub.2 --C.sub.1-6 alkyl,h) --SO.sub.2 --(CH.sub.2).sub.h -aryl, ori) --(CO).sub.i -Het;R.sub.1-1 isa) H,b) C-6 alkyl, optionally substituted with one or more OH, CN, or halo,c) --(CH.sub.2).sub.h -aryl, ord) --(CH.sub.2).sub.h --OR.sub.1-3 ;R.sub.1-2 isa) C.sub.1-6 alkyl, optionally substituted with one or more OH, CN, or halo,b) --(CH.sub.2).sub.h -aryl, orc) --(CH.sub.2).sub.h --OR.sub.1-3 ;R.sub.1-3 isa) H,b) C.sub.1 6 alkyl,c) --(CH.sub.2).sub.h -aryl, ord) --CO(C.sub.1-6 alkyl);R.sub.2 isa) H,b) C.sub.1-6 alkyl,c) --(CH.sub.2).sub.h -aryl, ord) halo;R.sub.3 and R.sub.4 are independentlya) H, orb) halo;R.sub.5 isa) H,b) C.sub.1-12 alkyl, optionally substituted with one or more halo,c) C.sub.3-12 cycloalkyl,d) C.sub.1 6 alkoxy;Het is 5- to 10-membered heterocyclic rings having one or more oxygen, nitrogen, and sulfur atoms;the dotted line - in the ring system of Formula I is a single or a double bound;h is 1, 2, 3, or 4;i is 0 or 1;m is 0, 1 or 2;n is 0, 1 or 2;and with the following provisiosa) m and n taken together are 1 or 2;b) where the dotted line ------ is a double bound, R.sub.2 is not present in formula I.