Patent ID: 6552230
Filing Date: 2003-04-22
Classification: C07C

Abstract:
A process for preparing a 2-nitro-5-(phenylthio)aniline of formula (I) whereinR1 represents hydrogen, C1-C8-alkyl, C3-C8-cycloalkyl, C1-C8-alkoxy, or halogen and R2 represents hydrogen, C1-C8-alkyl, C3-C8-cycloalkyl, C1-C8-alkoxy, halogen, or C6-C10-aryl optionally substituted with C1-C8-alkyl, C1-C8-alkoxy, or halogen, comprising(a) reacting a 2,4-dichloronitrobenzene of the formula wherein R1 is defined as for formula (I), â€ƒwith ammonia to form a 5-chloro-2-nitroaniline of the formula (II) wherein R1 is as defined for formula (I), (b) reacting the resultant 5-chloro-2-nitroaniline of the formula (II), in the same reaction vessel without intermediate isolation and in a solvent, with (i) a thiophenol of the formula (III) wherein R2 is as defined for formula (I), and (ii) ammonia.