Patent ID: 8771701
Filing Date: 2014-07-08
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method of eliciting a cytotoxic T lymphocyte response in an human to an antigen selected from the group consisting of a mucin polypeptide, one or more repeated subunits thereof and an antigenic fragment of said repeated subunits, said fragment comprising at least 5 amino acids of said repeated subunits, the method comprising pulsing mannose receptor-bearing antigen presenting cells in vitro or ex vivo with a conjugate comprising said antigen and a carbohydrate polymer wherein said carbohydrate polymer is a fully oxidized carbohydrate polymer comprising free aldehydes, and wherein said pulsing results in binding of said conjugate to said mannose receptor, and wherein said binding results in internalizing, processing and presenting of said antigen on said antigen presenting cells; and administering the pulsed antigen presenting cells to said human.