Patent ID: 8747889
Filing Date: 2014-06-10
Classification: A61K,A61P

Abstract:
1. A transdermal patch system for administering an analgesic through the skin, the system having a reduced potential for abuse, comprising: (a) an analgesic reservoir layer comprising an analgesic, the analgesic being selected from the group consisting of fentanyl and analogs thereof; (b) an antagonist reservoir layer comprising an antagonist for the analgesic that is dispersed within a polymer, wherein the antagonist is insoluble in the antagonist reservoir polymer, the antagonist reservoir layer comprising an external edge of the system; (c) a barrier layer, the barrier layer separating the antagonist reservoir layer from the analgesic reservoir layer, the barrier layer being impermeable to the analgesic and to the antagonist; wherein the system (i) prevents release of the antagonist from the system upon securing the system to a human patient for a period of up to 7 days; and (ii) provides release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic upon ingestion or immersion of the system in a solvent.