Patent ID: 6706698
Filing Date: 2004-03-16
Classification: A61K,A61P,C07F

Abstract:
A compound of formula (Ia): or a compound of formula (Ib): in which:X1, X2, X3, X4 and X5 are independently hydrogen, hydroxy, hydroxymethyl, C1-C3 alkoxymethyl straight or branched C1-C8 alkyl, straight or branched C1-C8 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, norbornyl, adamantyl, amino, primary or secondary amino substituted with C1-C3 alkyl, cyano, halogen (F, Cl, Br, I), and nitro; or X2 may be combined with X3, or X4 may be combined with X5, to form a 5- to 6-membered alkylidenedioxy ring optionally substituted with a C1-C4 alkyl group; or X4 may be combined with X5 to form a 5- to 6-membered alkylidene ring optionally substituted with a C1-C4 alkyl group, with the proviso that for formula (Ia) X1 is hydrogen, or methyl, X2 is methoxy, ethoxy, methyl or hydroxy, X3 is hydrogen, hydroxy, methoxy, ethyl, ethyl or hydroxymethyl, X4 is hydrogen, methoxy or methyl and X5 is hydrogen; R1 and R2, are independently hydrogen or a straight or branched C1-C6 alkyl; B is CH2 or CH2â€”CH2; n is zero or 1; Z0 is H, straight or branched C1-C4 alkyl, C1-C4 alkylcarbonyl, or C1-C4 perfluoroalkylcarbonyl; m is zero or an integer from 1 to 4; Het is an optionally substituted heteroaryl group selected from the group consisting of pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, thiazolyl, thiadiazolyl, benzothiazolyl, isoxazolyl, pyrazolyl, triazinyl, and imidazolyl; for a compound of formula (Ia), Y1, Y2 and Y3 are independently hydrogen or C1-C4 alkyl and for a compound of formula (Ib), Y3 is hydrogen or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof.