Patent ID: 6039970
Filing Date: 2000-03-21
Classification: A61K,Y10S

Abstract:
A method for administering a biologically active molecule across the nasal mucosal membrane which comprises administering an effective amount of a smooth surface microsphere which comprises a biologically active molecule and an ester of hyaluronic acid,wherein said biologically active molecule is adhered to said ester of hyaluronic acid,wherein said smooth surface microsphere has a diameter of between 1 .mu.m to 100 .mu.m, andwherein said smooth surface microsphere is formed by a process comprising:dissolving said ester of hyaluronic acid and said biologically active molecule in dimethylsulfoxide to produce a mixture;adding said mixture to mineral oil with stirring to produce an emulsion;adding ethyl acetate to said emulsion to produce a suspension;filtering said suspension; andrecovering smooth surface microspheres thus formed, to said nasal mucosal membrane.