Patent ID: 6800745
Filing Date: 2004-10-05
Classification: A61K,A61P,C07K

Abstract:
An isolated nucleic acid molecule encoding an indolicidin analog having the amino acid sequence:Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Pro-Xaa6-Xaa6-Pro-Xaa6-Pro-Xaa7-Xaa7-Xaa8, wherein:Xaa1 is Ile, Leu, Val, Ala, Gly or absent; Xaa2 is Ile, Leu, Val, Ala, Gly or absent; Xaa3 is Pro or absent; Xaa4 is Trp, Phe or absent; Xaa5 is Arg, Lys or absent; Xaa6 is Trp or Phe; Xaa7 is Arg, Lys or absent; and Xaa8 is Met-Xaa9-Met; wherein Xaa9 is at least one amino acid; and further provided that if Xaa2 is absent, Xaa1 is absent; if Xaa3 is absent, Xaa1 and Xaa2 are absent; if Xaa4 is absent, Xaa1, Xaa2 and Xaa3 are absent; and if Xaa5 is absent, Xaa1, Xaa2, Xaa3 and Xaa4 are absent.