Patent ID: 9180136
Filing Date: 2015-11-10
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of treating a subject having skin squamous cell carcinoma, the method comprising the steps of: testing the subject for tumor cells with reduced activity in the inositol polyphosphate5-phosphatase (INPP5A) pathway in comparison to a control in order to determine that the tumor cells are sensitive to a pharmaceutical composition comprising inositol hexaphosphate (IP6) and pharmaceutically acceptable salts thereof, wherein testing the subject for tumor cells with reduced activity in the INPP5A pathway consists of detecting the gene expression of INPP5A by hybridization with an oligonucleotide complementary to a portion of SEQ ID NO:1 or detecting the protein expression of INPP5A with an antibody that binds to a portion of SEQ ID NO:2; and administering an effective amount of the pharmaceutical composition to the subject when the subject is determined to have tumor cells that are sensitive to the pharmaceutical composition.