Patent ID: 6100258
Filing Date: 2000-08-08
Classification: A61P,C07D

Abstract:
Any compound according to formula Ia: ##STR31## wherein: A is selected from phenyl and naphthyl, where A is either unsubstituted, mono-, or di-substituted with halo;provided that the --CH(R.sup.3)N(R.sup.2)-linking group and the --OD group are positioned in a 1,2 relationship on A and the ring atom of A in the 3-position is not substituted;ring B is either unsubstituted or non-substituted with --SO.sub.p (C.sub.1 -C.sub.6)alkyl, carbamoyl, (C.sub.1 -C.sub.4)alkylcarbamoyl, di((C.sub.1 -C.sub.4)alkyl)carbamoyl, and G where G is selected from halo, trifluoromethyl, nitro, hydroxy, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkyl, amino, (C.sub.1 -C.sub.4)alkylamino, di((C.sub.1 -C.sub.4)alkyl)amino and cyano;R.sup.1 is positioned on ring B in a 1,4 relationship with the --CH(R.sup.3)N(R.sup.2)-linking group;R.sup.1 is selected from carboxy, carbamoyl, tetrazolyl, --CONR.sup.a R.sup.a1 where R.sup.a is hydrogen or (C.sub.1 -C.sub.6)alkyl and R.sup.a1 is (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkyl substituted by hydroxy, (C.sub.2 -C.sub.6)alkenyl 1-morpholinyl, 1-piperidinyl, 1-pyrrolidinyl, or pyridyl(C.sub.1 -C.sub.3)akyl,R.sup.2 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkyl substituted by hydroxy, cyano or trifluoromethyl, CH.sub.2 -(C.sub.1 -C.sub.5)alkenyl, CH.sub.2 -(C.sub.1 -C.sub.5)alkynyl, phenyl(C.sub.1 -C.sub.3)alkyl or pyridyl(C.sub.1 -C.sub.3)alkyl;R.sup.1 is hydrogen, methyl or ethyl;D is hydrogen, a 5-7 membered carbocyclic ring having one double bond, a 5-7 membered carbocyclic ring having one double bond mono-substituted with L where L is selected from (C.sub.1 -C.sub.4)alkyl, (C.sub.2 -C.sub.4)alkenyl, (C.sub.2 -C.sub.4)alkynyl halo, hydroxy, amino, (C.sub.1 -C.sub.4)alkylamino, di-((C.sub.1 -C.sub.4)alkyl)amino, cyano, trifluoromethyl, oxo, (C.sub.1 -C.sub.4)alkanoyl, (carboxy and carbamoyl, (C.sub.1 -C.sub.3)alkyl substituted with a 5-7 membered carbocyclic ring having one double bond, or a 5-7 membered carbocyclic ring having one double bond mono-substituted with L or (CH.sub.2).sub.n CH(R.sup.4)C(R.sup.5).dbd.C(R.sup.6)R.sup.7 where R.sup.4 is hydrogen, methyl or ethyl, R.sup.5 is methyl or M where M is hydrogen, bromo, chloro, fluoro or trifluoromethyl, R.sup.6 and R.sup.7 are (C.sub.1 -C.sub.4)alkyl or M, and n is 0 or 1;or compounds that are N-oxides of N--R.sup.2, where chemically possible;or a pharmaceutically-acceptable salt of any foregoing compound.