Patent ID: 7897560
Filing Date: 2011-03-01
Classification: A61K,A61P,C07K

Abstract:
1. A method of increasing intravascular half-life of an agent, said method comprising converting said agent into a compound of general formula (I): by reacting said agent with a compound of general formula wherein R C G is NH or CHW, wherein W is hydrogen, fluorine, cyano, nitro, C(═O)-E wherein E Z is S═O, S(═O) X represents a bond or optionally a spacer selected from C Y L is a leaving group for nucleophilic displacement, L being selected from hydroxy, halide, 2,6-dichlorobenzoyl, pivaloyl, 2- or 4-nitrophenyloxy, 2,4-dinitrophenloxy, benzotriazole-1-yloxy, 4-benzotriazol-3-yloxy, C and wherein R and the agent is selected from the group consisting of a GLP-1 peptide or a GLP-2 peptide.