Patent ID: 6248870
Filing Date: 2001-06-19
Classification: A61K,C07D

Abstract:
A method for diagnostic imaging a site in a patient comprising the steps ofa) administering to the patient an effective amount of a targeting radioactive immunoreagent capable of targeting said site, andb) imagewise activating a radiation sensitive element or device with the radiation emitted from the targeted site:said targeting radioactive immunoreagent comprising a metal radionuclide ion,a complexing agent, andan immunoreactive group linked to said complexing agentsaid complexing agent having the structure ##STR32##whereineach R and R.sub.1 is independently selected from hydrogen, alkyl, alkoxy, alkylthio, N,N-dialkylamino, alkylformamido, aryl, heterocyclyl and a protein reactive group;each of L.sub.1 and L.sub.2 is a linking group independently selected from a chemical bond, a methylene group (--CH.sub.2 --) and an imino group;Q is a chelating group;each n is independently 1, 2, 3 or 4; anda is 0 or 1.