Patent ID: 7067639
Filing Date: 2006-06-27
Classification: A61K,C07K,Y02A,Y10S

Abstract:
1. A method for binding a proteinaceous substance to cell-wall material of a Gram-positive bacterium, said method comprising: treating said cell-wall material with an acid solution, thus removing a cell-wall component selected from the group consisting of a protein, a lipoteichoic acid, a carbohydrate, and combinations thereof from said cell-wall material, thus producing spherical peptidoglycan microparticles; and contacting said spherical peptidoglycan microparticles with a proteinaceous substance, thus binding said proteinaceous substance to said spherical peptidoglycan microparticles; wherein said proteinaceous substance comprises an immunogenic determinant and an AcmA cell-wall binding domain, homolog, or functional derivative thereof that binds to the treated cell-wall material.