Patent ID: 8846877
Filing Date: 2014-09-30
Classification: B01J,C07K,Y10T

Abstract:
1. An affinity chromatography packing material, comprising: at least one porous mother particle that comprises a copolymer of a monomer mixture comprising a crosslinkable vinyl monomer and an epoxy group-comprising vinyl monomer, wherein: a ligand is bound to the porous mother particle; the porous mother particle comprises a ring-opening epoxy group produced by ring-opening of the epoxy group comprised in the porous mother particles; the ligand is bound to the porous mother particle by (i) utilizing the epoxy group comprised in the porous mother particles as a ligand binding site, (ii) activating an alcoholic hydroxyl group produced by ring-opening of the epoxy group comprised in the porous mother particles, and binding the ligand to the porous mother particles, or (iii) forming a linker that extends from the epoxy group comprised in the porous mother particles or a group produced by ring-opening of the epoxy group, and binding the ligand to the porous mother particles via the linker; and the ligand is an immunoglobulin-binding protein of formula (1), wherein R represents an amino acid sequence that comprises 4 to 300 amino acids and a site including 4 to 20 consecutive histidine residues, and R