Patent ID: 6689889
Filing Date: 2004-02-10
Classification: A61P,C07B,C07D,G01N

Abstract:
A process for the chromatographic separation of a mixture of enantiomers of (Â±)-trans-(E)-6-[2-(2,6-diisopropyl-4-(4-fluorophenyl)-3-methoxymethyl-pyrid-5-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one into separate enantiomers thereof, said process comprising separating the separate enantiomers from a mobile phase comprising said mixture of enantiomers by means of chiral stationary phase comprising A) an optically active polymer selected from the group consisting of an optically active polymer of N-acryloyl-S-phenylalanine d-neomenthyl-amide and an optically active polymer of an enantiomer of N-acryloyl-S-phenylalanine d-neomenthyl-amide, B) a crosslinked form of said optically active polymer and/or C) a carrier-bonded form of said optically active polymer.