Patent ID: 6586467
Filing Date: 2003-07-01
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R1 is selected from hydrogen, hydroxy, halogen, amino, monoalkylamino, trifluoromethyl, aminomethyl, cyano, nitro, and â€”COOR6; R2 is selected from hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, alkoxyalkyl, hydroxyalkyl, lower alkenyl, amino, mono- or dialkylamino, cyano, nitro, trifluromethyl, â€”CON(R6)2, and â€”COOR6; R3, R4, R5 are independently selected from hydrogen, hydroxy, halogen, lower alkyl, lower alkenyl, cycloalkyl, cyano, â€”CON(R6)2, â€”COOR6, and aryl optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, â€”C(O)R8, â€”COOR8, â€”C(O)NHR8, and â€”OR8; A is selected from â€”S(O)2R7 or â€”(CH2)nS(O)qR7; B is selected from hydrogen, lower alkyl, lower alkenyl, lower alkynyl, â€”(CH2)nS((O)qR7, â€”(CH2)pC(O)R7, â€”(CH2)pC(O)NHR7, â€”(CH2)pCO2R7, (CH2)nOR7, and aryl, arylalkyl, arylalkenyl and arylalkynyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, â€”C(O)R8, â€”COOR8, â€”C(O)NHR8, and â€”OR8; n is 2-4; p is 1-2; q is 0-2; R6 is selected from hydrogen, lower alkyl, and lower alkenyl; R7 is selected from lower alkyl, or aryl and arylalkyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, â€”C(O)R8, â€”COOR8, â€”C(O)NHR8, and â€”OR8; and R8 is independently selected from hydrogen, and lower alkyl and aryl optionally substituted with one, two or three groups independently selected from lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl.