Patent ID: 6380220
Filing Date: 2002-04-30
Classification: A61P,C07D

Abstract:
A piperidineketocarboxylic acid compound of the formula I or its tautomeric and isomeric forms, or physiologically tolerable salts thereof, where the variables have the following meanings:R1 is â€”COâ€”R4, â€”SO2â€”R4, â€”CONHâ€”R4, â€”COOR4, â€”C(&boxH;N)â€”R4, â€”C(&boxH;O)â€”NHR4 and â€”C(&boxH;S)â€”NHR4; R2 is â€”C1-C6-alkyl, which is branched or unbranched and can additionally carry a phenyl, pyridine or naphthyl ring which in turn can be substituted by at most two radicals R5 selected from the group consisting of C1-C4-alkyl which is branched or unbranched, â€”Oâ€”C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COOâ€”C1-C4-alkyl, â€”NHCOâ€”C1-C4-alkyl, â€”NHCOPh, â€”NHSO2â€”C1-C4-alkyl, NHSO2â€”Ph, â€”SO2â€”C1-C4-alkyl and â€”SO2Ph; R3 is â€”OR6 and â€”NHR6; R4 is â€”C1-C6-alkyl which is branched or unbranched, and in which optionally a chain of two or more C atoms may contain a double bond or triple bond and be substituted by one or two rings selected from the group consisting of phenyl, naphthalene, quinoxaline, quinoline, isoquinoline, pyridine, thiophene, benzothiophene, benzofuran, pyrimidine, thiazole, isothiazole, triazole, imidazole, cyclohexyl, cyclopentyl, fluorene, indole, benzimidazole, oxazole, isooxazole and furan, said rings optionally including up to two radicals R5; R6 is hydrogen, a phenyl ring which can additionally carry one or two radicals R5, C1-C6-alkyl which is branched or unbranched and can contain a double bond or a triple bond, and a ring such as phenyl, naphthalene, pyridine, pyrimidine, piperidine, pyrrolidine, morpholine, thiophene, quinoline and isoquinoline, said rings optionally carrying at most two radicals â€”NR7R8 or R5, R7 and R8 independently of one another being hydrogen or C1-C6-alkyl which is branched or unbranched.