Patent ID: 6822090
Filing Date: 2004-11-23
Classification: C07H

Abstract:
A method, characterized in that a uridine derivative represented by formula (1): wherein, X represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms substituted with at least one halogen atom, or an alkenyl group having 2 to 4 carbon atoms, and R1 and R2 each independently represent either a hydrogen atom or a hydroxyl-protecting group, and R3 represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having 1 to 4 carbon atoms, a cyano group, an alkenyl group, an alkynyl group, an alkoxy group having 1 to 4 carbon atoms or a protected hydroxyl group, is reacted with an alicyclic amine represented by formula (4): wherein, n and m each independently represent an integer of 1 to 4, Y represents a methylene group, oxygen atom, sulfur atom or an alkylamine having 1 to 4 carbon atoms provided that, when Y is a methylene group or an alkylamine having 1 to 4 carbon atoms, a carbon atom of either the methylene group or the alkylamine having 1 to 4 carbons atoms may be attached to A to form a ring, A represents an alkyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms substituted with at least one halogen atom, an alkenyl group having 2 to 4 carbon atoms, or A attached to Y may form a ring, or salts thereof, and dehydrating reactant, followed by reaction with ammonia, or a primary or a secondary amine represented by formula (2): HNR4R5â€ƒâ€ƒ(2) wherein, R4 and R5 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkyl group having 1 to 4 carbon atoms substituted with at least one halogen atom, or an alkenyl group having 2 to 4 carbon atoms, or R4 and R5 linked together may form a ring, for producing a cytidine derivative represented by formula (3):