Patent ID: 6406901
Filing Date: 2002-06-18
Classification: C07K,C12N

Abstract:
An isolated and purified polypeptide that is capable of converting TNF-&agr; from the 26 kD form to the 17 kD form, the polypeptide comprising an amino acid sequence selected from the group consisting of:(a) SEQ ID NO:9; (b) a fragment of SEQ ID NO:2, the fragment comprising the amino acid sequence of SEQ ID NO:9; (c) a fragment of SEQ ID NO:2, the fragment comprising the amino acid sequence of SEQ ID NO:2 from amino acid 215 to amino acid 477; (d) a fragment of SEQ ID NO:2 such that a polypeptide with an amino acid sequence consisting of said fragment is capable of converting TNF-&agr; from the 26 kD form to the 17 kD form; (e) a fragment of SEQ ID NO:4, the fragment comprising the amino acid sequence of SEQ ID NO:9; (f) a fragment of SEQ ID NO:4 such that a polypeptide with an amino acid sequence consisting of said fragment is capable of converting TNF-&agr; from the 26 kD form to the 17 kD form; and (g) an amino acid sequence that is at least 80% identical to the amino acid sequence of any of (a)-(f).