Patent ID: 6127368
Filing Date: 2000-10-03
Classification: A61P,C07D

Abstract:
A compound of the formulae I, or an isomer, tautomer or salt thereof ##STR15## in which R.sup.3 means hydrogen, C.sub.1-6 alkyl, --CO--R.sup.1, --C.ident.N, phenyl which optionally is substituted one to three times with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or --CF.sub.3, ##STR16## R.sup.4 means hydrogen, C.sub.1-6 alkyl, or C.sub.1-4 alkoxy-C.sub.1-2 alkyl, provided that R.sup.3 and R.sup.4 are not simultaneously hydrogen, andA represents a 5- to 6-membered unsaturated ring, in which 1-2 C atoms are optionally replaced by N, O and/or S and which is optionally substituted by R.sup.5 and R.sup.6, whereR.sup.5 and R.sup.6 are the same or different and mean hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy which is optionally functionally modified, NR.sup.7 R.sup.8, COR, C.sub.1-6 alkyl substituted with optionally functionally modified hydroxy, C.sub.1-4 alkoxy or halogens, a C.sub.6-12 aryl or a 5- to 6-membered hetaryl radical which contains one to three N, O and/or S atoms, the aryl and hetaryl radical optionally being substituted with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hetaryl or CF.sub.3, orR.sup.5 and R.sup.6 together mean a --(CH.sub.2).sub.n -- group andR.sup.1 and R mean hydroxy, C.sub.1-6 alkoxy or NR.sup.10 R.sup.11,R.sup.2 means hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy-C.sub.1-2 alkyl,R.sup.9 means hydrogen or C.sub.1-6 alkyl,n means 3 or 4,R.sup.7 or R.sup.8 each mean hydrogen, C.sub.1-6 alkyl, acyl or phenyl which is optionally substituted singly or repeatedly with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or CF.sub.3,R.sup.10 and R.sup.11 each mean hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl or a C.sub.6-12 aryl radical or a 5- to 6-membered hetaryl radical, which contains one to three N, O and/or S atoms, and the aryl and hetaryl radicals are optionally substituted singly or repeatedly with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or CF.sub.3.