Patent ID: 6794385
Filing Date: 2004-09-21
Classification: C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein:G is selected from the group consisting of: Q is NH or O; Qâ€² is selected from the group consisting of H, C1-C6 alkyl, phenyl, and phenyl-C1-C4-alkyl; Râ€² and Râ€³ are independently H or C1-C4-alkyl; B is C1-C4 alkyl or C2-C4 alkenyl; A is selected from the group consisting of CH2, O, S(O)p, NH, CON(Râ€²â€³), and N(Râ€²â€³)CO; p is zero, 1 or 2; Râ€²â€³ is hydrogen or CH3; R1 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, OH, halogen, and CF3; X is C&boxH;O or a bond, except that X is C&boxH;O when G is: R2 is selected from the group consisting of: H; C1-C4 alkyl; C3-C7 cycloalkyl; C1-C4-alkylcycloalkyl; aryl optionally substituted by one to three substituents independently selected from the group consisting of halogen, CF3, C1-C4 alkyl, hydroxy, and C1-C4 alkoxy; aralkyl; and a heteroaryl selected from the group consisting of pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, and isoxazolyl, wherein: any such heteroaryl is optionally substituted by one to three substituents independently selected from the group consisting of halogen, CF3, C1-C4 alkyl, hydroxy, and C1-C4 alkoxy; Y is (CH2)n; n is 1 or 2; and R is selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, and aryl-C1-C4 alkyl.