Patent ID: 6511978
Filing Date: 2003-01-28
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (1): in whichA represents hydrogen, lower alkyl, or a structure selected from the following group: whereinm1, m2, m and n independently of one another denote an integer of 0 to 5, Y represents O, S, S&boxH;O or SO2, R1 represents hydrogen, or represents optionally saturated 3- to 6-membered heterocycle or bicyclo 9- to 10-membered aromatic heterocycle, each of which has one or more hetero atoms selected from a group consisting of nitrogen, sulfur and oxygen, or represents a structure selected from the following group: wherein, X represents hydrogen, halogen, lower alkyl, lower alkoxy, nitro, cyano, hydroxy or phenoxy, R2 represents optionally saturated 3- or 9-membered heterocycle or bicyclo 9- or 10-membered aromatic heterocycle, each of which has one or more hetero atoms selected from a group consisting of nitrogen, sulfur and oxygen, or represents a structure selected from the following group: wherein p denotes an integer of 1 to 3, Y is defined as previously described, R11 and R12 independently of one another represent lower alkyl optionally substituted by phenyl or naphthyl, or represent C3-C7-cycloalkyl, phenyl or naphthyl, R3 represents lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl or lower alkylsulfonyl, each of which is optionally substituted by phenyl or naphthyl, or represents sulfonyl substituted by phenyl or naphthyl, R4 and R8 independently of one another represent hydrogen, lower alkyl, lower alkoxy or halogen, R5 and R7 independently of one another represent hydrogen, lower alkyl, lower alkoxy, halogen or hydroxy, R6 represents hydrogen, lower alkyl, lower alkoxy, hydroxy, di(lower alkyl)amine, C3-C6-cycloalkyl, C3-C6-cycloalkyl-lower alkyl, halogen, phenyl or phenoxy, R9 represents hydrogen or lower alkyl, R10 represents aralkyl optionally substituted by lower alkyl or halogen, B represents hydrogen, lower alkyl, lower alkylthio or amino, D represents hydrogen, lower alkyl, halogen, lower alkylthio, nitro or amino, E represents phenyl, or naphthyl optionally substituted by halogen, G represents nitro or amino, or represents a structure of wherein L represents a structure selected from the following group: whereinR13 and R14 independently of one another represent hydrogen, hydroxy, lower alkyl or lower alkoxy, Y is defined as previously described, J represents hydrogen, lower alkyl, lower alkylthio or phenyl, provided that A does not represent hydrogen, lower alkyl or any one structure selected from the following group: wherein m and R3 to R9 are defined as previously described, mâ€² denotes an integer of 1 to 5, when B, J and D represent hydrogen at the same time and G does not represent nitro or amino, or pharmaceutically acceptable salts or isomers thereof.