Patent ID: 6025371
Filing Date: 2000-02-15
Classification: C07D,C40B

Abstract:
A combinatorial library comprising compounds of the structure:P--Rwherein P is an azolopyrimidinedione, and wherein R is a substituted alkyl chain at the 3-position of the azolopyrimidinedione, and R is selected from the group consisting of: ##STR19## wherein R.sub.7, R.sub.8 and R.sub.9 are independently selected from the group consisting of H, alkyl, aryl, OH, NH.sub.2, NHR.sub.10, NR.sub.10 R.sub.11, SH, SR.sub.10, .dbd.O, C(O)R, and an amino acid side chain; and wherein Y is selected from the group consisting of alkyl, aryl, O, NH, and NR.sub.10 ; and wherein X is selected from the group consisting of CO.sub.2 H, CO.sub.2 R.sub.10, C(O)R.sub.10, SH, OH, NH.sub.2, NHR.sub.10, C(O)NHOH, and C(O)NHR.sub.10 ; and wherein R.sub.10 and R.sub.11 are independently selected from the group consisting of alkyl, aryl and heteroaryl; and further wherein m, n, o, and p vary independently from 0 to 4, ##STR20## wherein R.sub.7 and R.sub.8 are independently selected from the group consisting of H, alkyl, aryl, OH, NH.sub.2, NHR.sub.10, NR.sub.10 R.sub.11, SH, SR.sub.10, .dbd.O, C(O)R.sub.10, and an amino acid side chain; and wherein R.sub.10 and R.sub.11 are independently selected from the group consisting of alkyl, aryl and heteroaryl; and wherein m, n, and o vary independently from 0 to 4, and ##STR21## wherein R.sub.7 is independently selected from the group consisting of H, alkyl, aryl, OH, NH.sub.2, NHR.sub.10, NR.sub.10 R.sub.11, SH, SR.sub.10, .dbd.O, C(O)R.sub.11, and an amino acid side chain; and wherein X is selected from the group consisting of CO.sub.2 H, CO.sub.2 R.sub.10, C(O)R.sub.10, SH, OH, NH.sub.2, NHR.sub.10, C(O)NHOH, and C(O)NHR.sub.10 ; and wherein R.sub.10 and R.sub.11 are independently selected from the group consisting of alkyl, aryl and heteroaryl; and wherein m and n vary independently from 0 to 4.