Patent ID: 7947646
Filing Date: 2011-05-24
Classification: A61K,A61P,C07K

Abstract:
1. An isolated protein comprising a variant activin IIB receptor polypeptide (vActRIIB) wherein said polypeptide is selected from the group consisting of: (a) a polypeptide having the sequence set forth in SEQ ID NO: 18, except for a single amino acid substitution at position 28 wherein the substitution is W for E; (b) a polypeptide having the sequence set forth in amino acids 19 through 134 of SEQ ID NO: 18, except for a single amino acid substitution at position 28, wherein the substitution is W for E; (c) a polypeptide having the sequence set forth in amino acids 23 through 134 of SEQ ID NO: 18, except for a single amino acid substitution at position 28, wherein the substitution is W for E; and (d) a polypeptide consisting of the sequence set forth in amino acids 25 through 134 of SEQ ID NO: 18, except for a single amino acid substitution at position 28, wherein the substitution is W for E.