Patent ID: 6455499
Filing Date: 2002-09-24
Classification: A61K,Y10S

Abstract:
A method of treating a subject having a disorder associated with LHRH activity, comprising administering to a subject an effective amount of a peptide compound which inhibits LHRH activity, wherein the peptide compound comprises a structure:A-B-C-D-E-F-G-H-I-J whereinA is pyro-Glu, Ac-D-Nal, Ac-D-Qal, Ac-Sar, or Ac-D-Pal; B is His or 4-Cl-D-Phe; C is Trp, D-Pal, D-Nal, L-Nal-D-Pal(Nâ€”O), or D-Trp; D is Ser; E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile; F is D-Asn or D-Gln; G is Leu or Trp; H is Lys(iPr), Gln, Met, or Arg; I is Pro; and J is Gly-NH2 or D-Ala-NH2; or a pharmaceutically acceptable salt thereof, thereby treating a subject having a disorder associated with LHRH activity.