Patent ID: 6562825
Filing Date: 2003-05-13
Classification: A61P,C07C,C07D

Abstract:
A compound of general formula (I) wherein:each R1 represents a substituent independently selected from halogen, C1 to 6 alkyl, C1 to 6 alkoxy, amino, nitro, cyano, SO2NH2, C1 to 6 haloalkyl, C1 to 6 haloalkoxy and C1 to 6 alkylsulphonyl; m represents an integer 0 to 2; R2 represents hydrogen or C1 to 4 alkyl; R3 and R4 independently represent hydrogen, C1 to 4 alkyl or phenyl; each phenyl group being optionally substituted by one or more substituents chosen independently from halogen, amino, nitro, cyano, C1 to 6 alkyl, C1 to 6 alkoxy, SO3H, SO2NH2, C1 to 6 haloalkyl, C1 to 6 haloalkoxy and C1 to 6 alkylsulphonyl; each R5 independently represents hydrogen or C1 to 4 alkyl; n represents an integer 0 to 4; X represents a bond or C1 to 4 alkyl; Y represents C1 to 4 alkyl; Z represents OH or NR6R7; R6 and R7 independently represent hydrogen, C1 to 6 alkyl, C2 to 6 unsaturated alkyl; each alkyl group being optionally substituted by one or more substituents independently chosen from hydroxyl, C1 to 4 alkoxy, amino, NR8R9, 1-pyrrolidin-2-onyl and CO2R10; or the group NR6R7 together represents a 5 to 7 membered saturated or unsaturated azacyclic ring system optionally incorporating one or two further heteroatoms independently selected from N, O and S; said ring system being optionally further substituted by CO2R11, COR12, CONR13R14 or C1 to 4 alkyl; said alkyl group itself being optionally further substituted by hydroxyl; and R8, R9, R10, R11, R12, R13 and R14 independently represent hydrogen or C1 to 4 alkyl; or a pharmaceutically acceptable salt thereof.