Patent ID: 8470790
Filing Date: 2013-06-25
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of increasing visual evoked potential (VEP) in a visual cortex of a human subject suffering from an ocular disease wherein retinal photoceptor cells are degenerating or are degenerated, comprising: delivering to retinal neurons a nucleic acid expression vector wherein said vector comprises a nucleic acid that encodes a rhodopsin selected from the group consisting of: wherein said nucleic acid is operatively linked to a promoter sequence, and optionally, transcriptional regulatory sequences; and said vector is capable of being expressed in said retinal neurons, such that said retinal neurons transmit an increased visual evoked potential to the visual cortex in response to light stimulus when compared to the visual evoked potential measured in the visual cortex prior to administration of said nucleic acid expression vector.