Patent ID: 6242414
Filing Date: 2001-06-05
Classification: A61K

Abstract:
A method of treating a patient having a disease associated with increased synthesis and release of neutrophil elastase comprising administering to the patient an agent in an amount effective to ameliorate at least one symptom associated with the disease, whereinthe disease is severe acute pancreatitis, emphysema, rheumatoid arthritis, cystic fibrosis, or multiple organ failure;the agent is:Tissue Factor Pathway Inhibitor (TFPI),Ala-TFPI,a fragment of wild-type TFPI comprising the first and second Kunitz domains,a fragment of wild-type TFPI comprising the first and second Kunitz domains and a heparin binding region, ora fragment of wild-type TFPI comprising the first 160 amino acids of mature TFPI;and the agent is capable of inhibiting coagulation and the release of neutrophil elastase.