Patent ID: 8106078
Filing Date: 2012-01-31
Classification: A61P,C07D

Abstract:
1. A method for regulating angiogenesis in a human, comprising administering to a human an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted phenyl; iv) substituted or unsubstituted heteroaryl; or R said substitutions are independently chosen from one or more C R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted heteroaryl; said substitutions are independently chosen from one or more C Z is a unit having the formula: R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted aryl; iv) substituted or unsubstituted heterocyclic rings; or v) substituted or unsubstituted heteroaryl rings; said substitutions are independently chosen from one or more halogen, C i) —C(O)NH[C(R ii) —C(O)[C(R iii) —C(O)[C(R iv) —SO R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted aryl; iv) substituted or unsubstituted heterocyclic rings; or v) substituted or unsubstituted heteroaryl rings; the index n is 0 or 1; the indices w and z are each independently from 0 to 4 and the indices x and y are each independently from 1 to 4; or a pharmaceutically acceptable salt thereof.