Patent ID: 8318860
Filing Date: 2012-11-27
Classification: C07H

Abstract:
1. A method for fluid-phase synthesis of a first polymer formed from n monomers, comprising the following steps: a) providing a dissolved first compound, wherein said first compound is formed from a first monomer and a second polymer having a first specific solubility, wherein said first monomer and said second polymer are linked to one another by a first bond, wherein said first bond can be cleaved by a first cleavage reaction, wherein said first monomer has an active or an activatable first group, b) providing a dissolved second compound, wherein said second compound is formed from a second monomer and a third polymer having a second specific solubility, wherein said second monomer and said third polymer are linked to one another by a second bond, wherein said second bond can be cleaved by a second cleavage reaction, wherein said second monomer has an active or an activatable second group which, by way of a linking reaction, can react with the first group with formation of a third bond between the first and second monomers, wherein said first and second specific solubilities are different, c) contacting the first and second compounds in order for the linking reaction to occur, wherein, if the activatable first and/or the activatable second group are/is present, said first and/or said second group are/is activated by adding an activator, d) carrying out a precipitation reaction specific for the second or third polymer, and separating any first or second compound precipitated in the process and the reaction product formed in step c), e1) dissolving the separated first or second compound and the reaction product in a solvent, carrying out a precipitation reaction specific for the second or third polymer for which the precipitation reaction carried out in step d) was not specific, separating reaction products precipitated in the process, and dissolving the reaction product in said solvent or another solvent, or e2) contacting the separated first or second compound and the reaction product with a solvent in which essentially only the reaction product dissolves but in which the first or second compound precipitated in step d) essentially does not dissolve, f) carrying out the second cleavage reaction with the reaction product, wherein a further reaction product and the third polymer are formed, wherein the first active group is formed on said further reaction product, and g) (n−2)-fold repetition of steps b) to f), wherein the first compound is replaced by the further reaction product formed in step f), and the second compound is replaced in each case with a further compound, wherein said further compound is formed from a further monomer and the third polymer,