Patent ID: 6518281
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound of the formula: in which:one of R1 and R2 is R3â€”Xâ€” and the other is hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, lower alkyl, lower alkoxy, halo, or R3â€”Xâ€”; R3 is monocycloalkyl of up to 10 carbon atoms, polycycloalkyl of up to 10 carbon atoms, or benzocyclic alkyl of up to 10 carbon atoms; X is â€”CH2â€” or â€”Oâ€”; R5 is a divalent pyrrolidine, imidazole, or thiophene ring in which the divalent bonds are on vicinal ring carbon atoms; R6 is â€”COâ€”, â€”CH2â€”, â€”CH2COâ€”, or â€”SO2â€”; Y is â€”CO[X]Z, â€”Câ‰¡N, â€”OR8, alkyl of 1 to 5 carbon atoms, or aryl; [X]Z is â€”NH2, â€”OH, â€”NHR, â€”R9, â€”OR9, or alkyl of 1 to 5 carbon atoms; R8 is hydrogen or lower alkyl; R9 is alkyl or benzyl; and, n has a value of 0, 1, 2, or 3.