Patent ID: 7008791
Filing Date: 2006-03-07
Classification: A61K,A61P

Abstract:
1. Method of eliciting an IgA response in a mammal comprising administering orally to the mammal a composition comprising a nucleic acid operatively encoding an antigen complexed with or entrapped within liposomes formed from liposome forming components comprising a) at least one cationic compound b) zwitterionic phospholipid consisting of one or two compounds having the general formula II in which R R Y is —O— or a bond; X m is 3 when X the groups R in which at least 25% by mole of the individual liposome forming components have a transition temperature of more than 40° C., wherein the molar ratio of cationic compound to zwitterionic phospholipid is in the range 1:1 to 1:10, whereby an IgA response to the said antigen is generated.