Patent ID: 8852614
Filing Date: 2014-10-07
Classification: A61K,A61P,B82Y,C12N,Y10S

Abstract:
1. A cellular composition comprising: viable liver cells encapsulated in a high permeability hydrogel with network defects resulting from introduction of hydrophobic nanoparticles; wherein the composition is formed by combining in a precursor solution polyethylene glycol (PEG) diacrylate with poly(lactic-co-glycolic acid) (PLGA) nanoparticles, in the presence of viable liver cells and a polymerization initiator, wherein the diameter of the nanoparticles is from about 100 nm to about 100 μm diameter; and wherein the concentration of the nanoparticles is from 0.01% to 1% weight/volume of the precursor solution.