Patent ID: 6184404
Filing Date: 2001-02-06
Classification: C07B,C07C,C07F

Abstract:
A process for the enantioselective alkylation of aldehydes with organozinc compounds, comprising transferring a functionalized alkyl group (R-FG) to an aldehyde according to the equation I ##STR15##wherein R.sup.1 is selected from the group consisting of alkyl, aryl, functionalized alkyl and functionalized aryl,R.sup.Dum is an organic residue selected from the group consisting of--CH.sub.2 --C(R.sup.2, R.sup.3, R.sup.4) whereinR.sup.2 is selected from the group consisting of H, alkyl and aryl;R.sup.3 is selected from the group consisting of alkyl and aryl;R.sup.4 is selected from the group consisting of alkyl and aryl,and --CH--(CH.sub.3)(R.sup.5) whereinR.sup.5 is alkyl;(R-FG) is selected from the group consisting of alkyl and a functionalized alkyl group having a ketocarbonyl, ester, amine, carboxylic acid amide, nitrile, cyanate, isocyanate, ether, enolether, halogen, aromatic or CC multiple-bond function, whereinR.sup.Dum.noteq.R-FG; and wherein the solvent is selected from the group consisting of a 5 to 12 carbon aliphatic hydrocarbon, an aromatic hydrocarbon, an ether and a chlorinated hydrocarbon, andwherein * in compound IV is a chiral center of compound IV.