Patent ID: 6562854
Filing Date: 2003-05-13
Classification: A61F,C07D,C07F

Abstract:
A compound having the formula: in which: n2 is 1, 2 or 3; each R2 is independently a halogen; R4 is â€”C(O)NHâ€”X6â€”(R15) wherein: X6 is (C1-4)alkylene or hetero(C2-4)alkylene; R15 is (C6-14)aryl optionally substituted with one to three sub substituents independently selected from (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkyloxycarbonyl, carboxy, carbamoyl, halo, hydroxy and tetrazol-1-yl; R5 is hydrogen or (C1-4)alkyl; R6 is hydrogen or (C1-4)alkyl, which alkyl is optionally substituted with one to two substituents independently selected from (C1-4)alkyloxy, hydroxy and sulfo; R7 is hydrogen or (C1-6)alkyl; and R8 is hydrogen or (C1-6)alkyl; or an N-oxide derivative, prodrug derivative, protected derivative, individual isomer, mixture of isomers or a pharmaceutically acceptable salt thereof.