Patent ID: 6716850
Filing Date: 2004-04-06
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of the formula I: where;R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy; X is â€”(CHR8)nâ€”Dâ€”(CHR8)mâ€”; D is â€”NR9â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€” or â€”S (&boxH;O)2â€”; R8 is independently H, C1-C3 alkyl, halo substituted C1-C3alkyl; R9 is H, C1-C3 alkyl; n and m are independently 0, 1 or 2; or prodrugs or pharmaceutically acceptable salts thereof.