Patent ID: 6350464
Filing Date: 2002-02-26
Classification: A61K,A61P,Y10S

Abstract:
A biodegradable polymer composition suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer, said composition comprising:(a) at least one antineoplastic agent and (b) a biodegradable polymer comprising the recurring monomeric units shown in formula III â€ƒwherein X is â€”Oâ€” or â€”NR4â€”, where R4 is H or alkyl; Y is â€”Oâ€”, â€”Sâ€” or â€”NR4â€”; M1 is (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; L is a divalent, branched or straight chain aliphatic group having 1-20 carbon atom; R3 is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and n is about 5-5,000; wherein said polymer composition provides extended release of said antineoplastic agent into the peritoneum of said subject; and wherein said composition increases the median survival rate from said cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of said antineoplastic agent without said biodegradable polymer.