Patent ID: 6780639
Filing Date: 2004-08-24
Classification: A61K

Abstract:
An adeno-associated virus vector comprising:an antibiotic inducible/repressible genetic construct for controlling the transciption of a gene of interest by a cell, wherein said genetic construct comprises a bi-directional antibiotic controlled activator-responsive promoter/operator sequence, said bi-directional antibiotic controlled activator-responsive promoter/operator sequence being located between a gene of interest and a cistron, wherein said bi-directional antibiotic controlled activator-responsive promoter/operator sequence controls the transcription of said gene of interest and of a cistron, and wherein said cistron encodes an antibiotic-controlled transactivator; and two bi-directional polyadenylation sequences (poly-A), wherein one of said bi-directional polyadenylation sequences is located between said gene of interest and a viral terminal sequence and the other bi-directional polyadenylation sequence is located between said cistron and a viral terminal sequence, wherein the antibiotic is tetracycline or an analog of tetracycline.