Patent ID: 6734196
Filing Date: 2004-05-11
Classification: A61P,C07D

Abstract:
A method for treating a living animal body afflicted with a condition selected from deficiencies in memory associated with cerebral aging and with neurodegenerative diseases comprising the step of administering a compound selected from those of formula (I): wherein:A represents pyridine, pyridinium, or piperidine, R2 represents hydrogen and R3 represents hydroxy, or R2 and R3 together form oxo, R4 represents substituted phenyl or substituted naphthyl, R1 represents hydrogen, R5 represents a group of formula (II): â€ƒwherein Râ€²1 represents hydrogen, Râ€²2 represents hydrogen and Râ€²3 represents hydroxy, or Râ€²2 and Râ€²3 together form oxo, Râ€²4 represents unsubstituted or substituted phenyl or unsubstituted or substituted naphthyl, or Râ€²1 and Râ€²4, together with two carbon atoms carrying them, form a ring containing 6 carbon atoms, or Râ€²1 and Râ€²2 form an additional bond and, in that case, Râ€²3 represents a 5- or 6-membered heterocycle that contains a nitrogen atom by which it is bound and that may contain another hetero atom selected from sulphur, oxygen, and nitrogen, R6 represents hydrogen or linear or branched (C1-C6)alkyl, the group R6 being present or absent depending on the nature of the ring A, heteroaryl being understood to mean an aromatic, mono- or bicyclic, 5-to 10-membered group containing 1 to 3 hetero atoms selected from oxygen, nitrogen, and sulphur, the term substituted, used with respect to the expressions phenyl, naphthyl, and heteroaryl, being understood to mean that the groups concerned may be substituted by one or more groups, which may be the same or different, selected from linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, mercapto, linear or branched (C1-C6)alkylthio, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino, in which each alkyl moiety is linear or branched, linear or branched (C1-C6)polyhaloalkyl, hydroxy, and halogen, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base, which compound is effective for alleviation of such condition.