Patent ID: 9144594
Filing Date: 2015-09-29
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of treating proteinuric kidney disease associated with cytosolic cathepsin L activity, comprising: administering to a patient having proteinuric kidney disease associated with cytosolic cathepsin L activity a therapeutically effective amount of a small molecule inhibitor of cytosolic cathepsin L activity to treat the proteinuric kidney disease, wherein the small molecule inhibitor of cytosolic cathepsin L activity is selected from the group consisting of: E-64, E-64a, E-64b, E-64c, E-64d, CA-074, CA-074 Me, CA-030, CA-028, Z-Phe-Phe-FMK, H-Arg-Lys-Leu-Trp-NH2, N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde, Z-Phe-Tyr(tBu)-diazomethylketone, Z-Phe-Tyr-aldehyde, and combinations thereof.