Patent ID: 7576131
Filing Date: 2009-08-18
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating insulin resistance in a human, comprising: administering to said human a therapeutically effective amount of a composition comprising the (−) stereoisomer of a compound of Formula I, wherein: R is a member selected from the group consisting of a hydroxy, lower aralkoxy, di-lower alkylamino-lower alkoxy, lower alkanamido lower alkoxy, benzamido-lower alkoxy, ureido-lower alkoxy, N′-lower alkyl-ureido-lower alkoxy, carbamoyl-lower alkoxy, halophenoxy substituted lower alkoxy, carbamoyl substituted phenoxy, carboxy-lower alkylamino, N,N-di-lower alkylamino-lower alkylamino, halo substituted lower alkylamino, hydroxy substituted lower alkylamino, lower alkanolyloxy substituted lower alkylamino, and lower alkoxycarbonylamino; each X is independently a halogen; or a pharmaceutically acceptable salt thereof; and wherein the-composition contains the (−) stereoisomer in an enantiomeric excess of at least 80% with respect to the (+) stereoisomer of the compound.