Patent ID: 9139827
Filing Date: 2015-09-22
Classification: A61K,A61P,C12N

Abstract:
1. A nanoparticle composition comprising a duplex, the duplex comprising: (a) a ribonucleic acid (RNA) polynucleotide functionalized to the nanoparticle and comprising a sequence that is identical to a target polynucleotide; and (b) an additional polynucleotide having a sequence that forms the duplex with the RNA polynucleotide under conditions appropriate to form the duplex, the duplex providing a polypeptide interaction site; the additional polynucleotide having at least one domain sufficiently complementary to a sequence in the target polynucleotide to permit hybridization of the additional polynucleotide to the target polynucleotide under appropriate conditions; wherein the duplex is located distal and not proximal to the nanoparticle, and the distance of the duplex from the nanoparticle is equivalent to at least 10 nucleotides.