Patent ID: 6472415
Filing Date: 2002-10-29
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of the formula: wherein:X is nitro, cyano or halogen; V is CF3, halogen or H; W is OH when T is H and is methyl when T and T1 are taken together to form a C&boxH;Z bridge; U is N when T and T1 are taken together to form a C&boxH;Z bridge or is taken together with T1 to form a bond or O or N; Q is a chalcogen; n is 1 or 2and d is 0 or 1; when d is 0, T and T1 are hydrogen; when d is 1, then: when n is 1, Y is a bond or linking group of from 1 to 10 carbon atoms and from 0 to 6 heteroatoms in the chain, where the heteroatoms are N, O, or S; Z, when other than taken together with Y, is an aliphatic group of from 1 to 6 carbon atoms, a polyfluoroacylamido group of from 2 to 8, carbon atoms and having at least 2 fluorines and not more than 2mâˆ’1 fluorines, wherein m is the number of carbon atoms, or haloanilino, where halo is of atomic number 9 to 80; and when n is 2, Y and Z are taken together to form a bond or a linking group of from 1 to 10 carbon atoms and from 0 to 6 heteroatoms, with from 0 to 4 heteroatoms in the chain, where the heteroatoms are N, O, and S.