Patent ID: 6613911
Filing Date: 2003-09-02
Classification: A61K,A61P,C07D

Abstract:
A process for the preparation of a compound having the formula I or a pharmaceutically acceptable salt thereof, wherein:R1, R2, R4, R5, R6, R8, R9, R12 and R13 are each independently hydrogen, alkyl, aryl or heteroaryl; R3, R7, R10 and R11 are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy; and X is CH or N; which comprises the steps of: (a) reacting an alkylarylacetate or alkylarylacetic acid compound having the formula VIII wherein:R1, R2, R3, R4, R5 and X are as described hereinabove; R is hydrogen, alkyl, aryl or heteroaryl; and W is halogen or sulfonate; with a 5-(2-oxazolylalkylthio)-2-aminothiazole compound having the formula VI wherein:R6, R7, R8, R9, R10 and R11 are as described hereinabove; in the presence of a coupling reagent and in a suitable solvent or solvent mixture to form an amide; and (b) reacting the amide with an amine in a suitable solvent or solvent mixture to form the compound of formula I.