Patent ID: 9072809
Filing Date: 2015-07-07
Classification: A61F,A61K,A61L,A61P,C08J

Abstract:
1. An in vivo gelling pre-formulation for the treatment of retinal detachment, comprising: (a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethyleneglycol chain and terminates in a nucleophilic group selected from a hydroxyl, thiol, and amino; (b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethyleneglycol chain and terminates in an electrophilic group selected from an epoxide, maleimide, succinimidyl, and an alpha-beta unsaturated ester; and (c) a viscosity enhancer selected from hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, sodium hyaluronate, polyvinyl alcohol, and polyvinylpyrrolidone; wherein the viscosity of the in vivo gelling pre-formulation is between about 5 cP and 4000 cP; and wherein the in vivo gelling pre-formulation polymerizes and/or gels at a target site of an eye to form a biocompatible retinal patch.