Patent ID: 6262023
Filing Date: 2001-07-17
Classification: C07K

Abstract:
A method to modulate the localized enzymatic activity of a first target protein that interacts with a second protein containing at least one WD-40 region, which method comprises contacting a first target protein having at least one WD-40 region with a peptide of 4-50 amino acids having an amino acid sequence derived from a sequence of the same length in said WD-40 region of said second protein under conditions wherein said contact results in the formation of a complex between said peptide and said first target protein, wherein said first target protein is selected from the group consisting of protein kinase C (PKC) and .beta. adrenergic receptor kinase (.beta.ARK) and wherein said WD-40 region has either the amino acid sequence set forth in the group consisting of: SEQ ID NO:69; SEQ ID NO:70; SEQ ID NO:71; SEQ ID NO:72; SEQ ID NO:73; SEQ ID NO:74; and SEQ ID NO:75 or has the amino acid sequence set forth in SEQ ID NO:28-SEQ ID NO:68.