Patent ID: 8790887
Filing Date: 2014-07-29
Classification: A61K,A61P,C12N,C12Y,G01N

Abstract:
1. A method of identifying compounds that modulate endosomal redistribution, the method comprising: administering a test compound to a first cell culture and a second cell culture; wherein the first and second cell cultures lack endogenous presenilin expression or function; and wherein only one of the first and second cell cultures stably expresses ADP-ribosylation factor 6 (ARF6); imaging at least one morphological parameter of the cells in the first cell culture; and imaging the at least one morphological parameter of the cells in the second cell culture; wherein, a deviation in the at least one morphological parameter between the first and second cell cultures identifies the test compound as a compound that modulates endosomal redistribution.