Patent ID: 6699979
Filing Date: 2004-03-02
Classification: A61K,A61P,C07H,C12N,C12P,C12Q

Abstract:
A compound having the structure: wherein: Q is O or CH2; Rx is lower alkyl, substituted lower alkyl, Cl, Br, CN, CF3, OCF3, OCN, O-alkyl, substituted O-alkyl, S-alkyl, substituted S-alkyl, SOMe, ONO2, NO2, N3, NH2, NH-alkyl, substituted NH-alkyl, OCH2CH&boxH;CH2, OCH&boxH;CH2, OCH2CCH, OCCH, aralkyl, heteroaraalkyl, heterocycloalkyl, polyalkylamino or substituted silyl; Bx is a nucleoside base, a blocked nucleoside base, a nucleoside base analog, or a blocked nucleoside base analog; and L is a leaving group, OH, or together L and Bx are a 2-3â€² or 6-3â€² pyrimidine or 8-3â€² purine cyclo-nucleoside.