Patent ID: 8821879
Filing Date: 2014-09-02
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A stable pharmaceutical formulation comprising a plurality of antibodies directed to at least one serotype of botulinum neurotoxin (BoNT) each of which antibodies specifically recognizes and binds a different epitope or a different BoNT serotype and is present at a concentration of at least about 1 mg/mL, an effective amount of a succinate buffer in a concentration from about 5 mM to about 15 mM, and an effective amount of arginine in a concentration of from about 140 mM to about 144 mM, wherein the pH of the formulation is between about 5 and about 6.5, wherein the formulation is stable at room temperature for at least 30 days, and wherein the plurality of antibodies comprises a first antibody comprising a heavy chain variable region of SEQ ID NO.3 and a light chain variable region of SEQ ID NO.4, a second antibody comprising a heavy chain variable region of SEQ ID NO.1 and a light chain variable region of SEQ ID NO.2, and a third antibody comprising a heavy chain variable region of SEQ ID NO.5 and a light chain variable region of SEQ ID NO.6.