Patent ID: 6531478
Filing Date: 2003-03-11
Classification: A61P,C07D

Abstract:
A compound of the formula (I): wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, sulfonylamino, and unsubstituted or substituted arylsulfonyl; wherein the substituents on the arylsulfonyl are one or more independently selected from halogen, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl or trifluoromethoxy; R3 is selected from the group consisting of unsubstituted or substituted aryl and unsubstituted or substituted heteroaryl; wherein the substituents on the aryl or heteroaryl are one or more independently selected from halogen, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, trifluoromethoxy, amino, C1-C6alkylamino or di (C1-C6alkyl) amino; L is selected from the group consisting of unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl and C3-C8cycloalkyl; wherein the substituents on the aryl or heteroaryl are one or more independently selected from halogen, C1-C4alkyl or trifluoromethyl; n is an integer selected from 0 or 1; X is selected from the group consisting of sulfonylamino, aminocarbonyl, carbonyl, carbonylamino, sulfonyl, sulfonylaminoC1-C6alkyl and C1-C6alkylaminosulfonyl; and p is 1;alternatively X is selected from the group consisting of di(unsubstituted or substituted arylsulfonyl)amino; wherein the substituents on the aryl group are one or more independently selected from halogen, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, trifluoromethoxy, C1-C6alkylcarbonylamino, amino, C1-C6alkylamino or di(C1-C6alkyl)amino, and wherein the two aryl groups of the di(unsubstituted or substituted arylsulfonyl)amino have the same substitution pattern; and p is 0; R4 is selected from the group consisting of unsubstituted or substituted aryl, C1-C6aralkyl, unsubstituted or substituted heteroaryl and unsubstituted or substituted heterocycloalkyl; wherein the substituents on the aryl, heteroaryl or heterocycloalkyl are one or more independently selected from halogen, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, trifluoromethoxy, amino, C1-C6alkylamino, di (C1-C6alkyl)amino, nitro or cyano; R5 is hydrogen; provided that when R1 and R5 are both hydrogen, and R3 is phenyl, or methylphenyl, and n is 1, and L is phenyl, and X is sulfonylamino, and R2 is methylphenylsulfonyl, then R4 is selected from the group consisting of unsubstituted or substituted aryl, wherein the substituents on the aryl are one or more independently selected from halogen, C1-C6alkoxy, trifluoromethyl, trifluoromethoxy, amino, C1-C6alkylamino, di (C1-C6alkyl)amino, nitro or cyano; C1-C6aralkyl, unsubstituted or substituted heteroaryl and unsubstituted or substituted heterocycloalkyl; wherein the substituents on the heteroaryl or heterocycloalkyl are one or more independently selected from halogen, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, trifluoromethoxy, amino, C1-C6alkylamino, di (C1-C6alkyl) amino, nitro or cyano; and pharmaceutically acceptable salts thereof.