Patent ID: 6022711
Filing Date: 2000-02-08
Classification: A61K,C07K,C12N,C40B,G01N,Y10S

Abstract:
A variant of a naturally occurring human growth hormone, wherein said variant has a greater affinity for human growth hormone receptor at site 1 than said naturally occurring human growth hormone, said variant differing from a naturally occurring amino acid sequence of human growth hormone in that said variant comprises a set of amino acid substitutions selected from the group consisting of:H18D, Q22A, F25A, D26A, Q29A, E65A, K168A, E174S;H18A, Q22A, F25A, D26A, Q29A, E65A, K168A, E174S; andH18D, Q22A, F25A, D26A, Q29A, E65A, K168A, E174A, numbered from the mature N-terminus of 191-amino acid human growth hormone.