Patent ID: 6264966
Filing Date: 2001-07-24
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A method for inhibiting body odors in a subject comprising administering to said subjet cosmetic/personal are products into which are incorporated a complexing agent having the formula ##STR213##wherein,p and q are independently integers of from 2 to 3;r is an integer of from 1 to 4;R.sup.2, R.sup.3, and R.sup.4 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by oxa, alkenyl interrupted by oxa, alkyl interrupted by thia, alkenyl interrupted by thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, and halogen-substituted versions thereof;R.sup.1 is a member selected from the group consisting of R.sup.2, R.sup.3, R.sup.4, and radicals of the formula: ##STR214##wherein,R.sup.41, R.sup.42, and R.sup.43 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by oxa, alkenyl interrupted by oxa, alkyl interrupted by thia, alkenyl interrupted by thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, and halogen-substituted versions thereof;R.sup.44 is a member selected from the group consisting of H, hydroxy, amino, alkyl interrupted by oxa, alkoxy, aryl, aryloxyalkyl, alkoxyaryl, alkoxyaryl, and halogen-substituted versions thereof;n is zero or 1; andX is a member selected from the group consisting of alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenoxy, alkenylthio, aryloxy, arylthio, alkyl interrupted by oxa, alkenyl interrupted by oxa, alkyl interrupted by thia, alkenyl interrupted by thia, aryloxyalkyl, alkoxyaryl, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, hydroxyarylalkyl, halogen-substituted versions thereof, and radicals selected form the group consisting of: ##STR215##wherein,R.sup.41, R.sup.42, R.sup.43 and R.sup.44 are each independently as defined above;R.sup.46 and R.sup.47 are each independently selected from the group consisting of H, alkyl and aryl, or taken together form a ring structure;R.sup.48 and R.sup.49 are each independently selected from the group consisting of H, alkyl, aryl, alkoxy, alkyl interrupted by oxa, aryloxyalkyl, alkoxyaryl, and halogen-substituted versions thereof;R.sup.50, R.sup.51 and R.sup.52 are each independently selected from the group consisting of H, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkylthio, alkenyloxy, alikenylthio, aryloxy, aminoalkyl, aminoalkenyl, aminoaryl, aminoarylakyl, hydroxyalkyl, hydroxyalkenyl, hydroxyaryl, and hydroxyarylalkyl; andm is an integer of from 1 to 3and wherein, optionally, any two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are combined to form a ring structure;and dimers of Formula I, said dimers being formed by the covalent attachment of two complexing agents of Formula I through a linking group having from 1 to 6 carbon atoms; and physiological salts thereof;with the proviso that the molecular weight of said complexing agent does not exceed 2000.