Patent ID: 6337350
Filing Date: 2002-01-08
Classification: A61K,A61P

Abstract:
A method of inhibiting formation of glycation endproducts or protein crosslinking resulting from glycation in a mammal in which it is desired to inhibit formation of glycation endproducts or protein crosslinking, wherein said method comprises administering an amount of a compound or a pharmaceutically acceptable salt of said compound to said mammal wherein said amount is effective in inhibiting formation of glycation endproducts or protein crosslinking, wherein said compound is selected from the group consisting of:4-[3-(6-chloro-2,4-(1H, 3H) quinazolinedione)]phenoxyisobutyric acid; 4-(2-furoylcarboxamido)phenoxyisobutyric acid; 4-(3,5-dichlorophenylureido)phenoxyisobutyric acid; 4-(4-ethylcarbamatophenylureido)phenoxyisobutyric acid; 4-(3,4-dichlorophenylureido)phenoxyisobutyric acid; 4-cyclohexylureidophenoxyisobutyric acid; 4-(2,3-dichlorophenylureido)phenoxyisobutyric acid; 4-(4-carboxaldehydophenylureido)phenoxyisobutyric acid; 4-(2-naphthylcarboxamido)phenoxyisobutyric acid; 4-(4-methoxyphenylureido)phenoxyisobutyric acid; 4-(3,4-dimethoxyphenylureido)phenoxyisobutyric acid; 4-(4-chloro-3-nitrophenylureido)phenoxyisobutyric acid; 4-(4-methylphenylureido)phenoxyisobutyric acid; 4-(3,4,5-trimethoxyphenylureido)phenoxyisobutyric acid; 4-(3-chlorophenylureido)phenoxyisobutyric acid; N-4-(nitrophthalimido)phenoxyisobutyric acid; 4-(2-thienylcarboxamido)phenoxyisobutyric acid; 4-(4-pyridylureido)phenoxyisobutyric acid; 4-(3,4,5-trichlorophenylureido)phenoxyisobutyric acid; L-bis-[4-(4-chlorobenzamidophenoxyisobutyryl)cystine]; 4-(3,4-dichlorophenylureido)phenoxyisobutyrylamidomethylcyclohexyl-4-carboxylic acid; DL-N-4-[(3,4-dichlorophenylureido)phenoxyisobutyryl]pipecolic acid; 4-(3,5-dichlorophenylureido)phenoxyisobutyryl-1-amidocyclohexane-1-carboxylic acid; 4-(4-iodophenylureido)phenoxyisobutyric acid; 4-(4-dimethylaminophenylureido)phenoxyisobutyric acid; 4-(2,4,6-trichlorophenylureido)phenoxyisobutyric acid; 4-(2,4,6-trimethylphenylureido)phenoxyisobutyric acid; 4-(4-chlorophenoxyacetamido)phenoxyisobutyric acid; 4-(4-chloro-3-nitrobenzoylcarboxamido)phenoxyisobutyric acid; 4-chlorodiphenylurea-4â€²-carboxylic acid; 4-(3,4-dichlorophenylacetamido)phenoxyisobutyric acid; diphenylurea-4-carboxylic acid; 4-(2-chloro-4-nitrophenylureido)phenoxyisobutyric acid; 4-(nicotinylamido)phenoxyisobutyric acid; 4-chlorophenoxyisobutyric acid; 4-(benzylsulfonamido)phenoxyisobutyric acid; 4-(2,5-dichlorobenzoylcarboxamido)phenoxyisobutyric acid; L-4-chlorobenzoylphenylalanine; 2-isopropyl-5-methylphenoxyisobutyric acid; 4-(3,4-dimethoxyphenylureido)phenoxyisobutyric acid; 4-(3-chloro-4-fluorophenylureido)phenoxyisobutyric acid; 4-(3,5-dichlorobenzamidoethyl)phenoxyisobutyric acid; 4-(phenylureido)phenoxyisobutyric acid; 4-(phenylureido-2-chloro)phenoxyisobutyric acid; 4-(2,6-dichloro-4-nitrobenzoylcarboxarnido)phenoxyisobutyric acid; 4-(3,5-difluorophenylureido)phenoxyisobutyric acid; 4-(N-methyl-4-chlorobenzamido)phenoxyisobutyric acid; 4-(4-nitrophenylureido)phenoxyisobutyric acid; 4-(phenylureido)phenoxyacetic acid; 4-(4-chlorobenzoylcarboxamido)phenoxyisobutyric acid; 4-(2-hydroxy-4-chlorobenzoylcarboxamido)phenoxyisobutyric acid; 4-(2-hydroxy-3,5-dichlorobenzoylcarboxamido)phenoxyisobutyric acid; 4-(2-chloro-5-nitrophenylureido)phenoxyisobutyric acid; 4-carboxyphenoxyisobutyric acid; 4-(4-carboxyphenylureido)phenoxyisobutyric acid; 2-ureidophenoxyisobutyric acid; urea 1,3-bis-4-phenoxyisobutyric acid; 4-(4-morpholinosulfonylphenylureido)phenoxyisobutyric acid; 4-[(3,4-dichlorophenylmethyl)2-chlorophenylureido]phenoxyisobutyric acid; 4-(3-pyridylureido)phenoxyisobutyric acid; 4-[(3,5-dichlorobenzoylamino)methyl]phenoxyisobutyric acid; 4-(2,4-dichlorophenacylamino)phenoxyisobutyric acid; 4-(benzylureido)phenoxyisobutyric acid; 4-acetamidobenzoic acid; 2-chloro-4-acetamidobenzoic acid; 4-aminophenoxyisobutyric acid; 2-acetamidoterephthalic acid; 5-chloro-2-acetoxybenzoic acid; 2-acetamido-5-acetoxybenzoic acid; 2-amino-5-hydroxybenzoic acid; 2-(8-quinolinoxy)propionic acid; N-guanylguanidino-Nâ€²-4-phenoxyacetic acid; 2-(2,5-dichlorophenoxy)propionic acid; 4-dimethylaminobenzoic acid; 2-amino4,5-dimethoxybenzoic acid; 4-sulfonamidobenzoic acid; 2-amino-4-chlorobenzoic acid; 4-hydroxyphenylbutyric acid; 2-methyl-4-quinolinecarboxylic acid; 2-methyl-3,4-quinolinedicarboxylic acid; 6-bromo-2-methyl-3,4-quinolinedicarboxylic acid; 4-acetamidophenoxyacetic acid; 1-(4-chlorophenoxybutyrylamido)-1-cyclohexanecarboxylic acid; 4-chlorophenylaminocarbonyliminodiacetic acid; 3-chloro-4-nitrophenylureidophenoxyisobutyric acid; methylene bis [4,4â€²-(2-chlorophenylureidophenoxyisobutyric acid)]; N,Nâ€²-bis(2-chloro-4-carboxyphenyl)formamidine; and N,Nâ€²-bis(2-carboxyphenyl)formamidine.