Patent ID: 6479035
Filing Date: 2002-11-12
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical solution aerosol formulation which comprises:(i) fluticasone propionate at a concentration of 0.025 to 0.15% w/v (ii) a hydrofluoroalkane (HFA) propellant which is 1,1,1,2-tetrafluoroethane (HFA134a); (iii) a low volatility component at a concentration of 0.5 to 3% w/w to increase the mass median aerodynamic diameter (MMAD) of aerosol particles on actuation of an inhaler containing said formulation; and (iv) ethanol as a solubilisation agent in sufficient quantity to solubilise the fluticasone propionate in the formulation and being present at a concentration of 5 to 30% w/w; characterised in that the fluticasone propionate is completely dissolved in the formulation.