Patent ID: 8957023
Filing Date: 2015-02-17
Classification: A61K,C07K,C12P

Abstract:
1. A method for treating a condition treatable with growth hormone comprising administering to a patient in need thereof an effective amount of a cysteine variant of human growth hormone, wherein said cysteine variant comprises a cysteine residue substituted for an amino acid selected from the group consisting of amino acid P2, T3, P5, A34, K38, Q40, S43, S55, S57, A98, N99, S100, L101, V102, Y103, A105, S132, P133, R134, T135, Q137, K140, Q141, Y143, S144, D147, T148, N149, E186, and G187, or wherein a cysteine residue is added preceding the first F1 amino acid of human growth hormone or following the terminal F191 amino acid of human growth hormone, wherein the composition is administered to the patient by a route selected from the group consisting of intravenous administration, intraperitoneal administration, and subcutaneous administration.