Patent ID: 9198975
Filing Date: 2015-12-01
Classification: A61B,A61K,C07K,G01N

Abstract:
1. A method for delivering a bioactive compound to a site of neovascular growth, said method comprising administering an effective amount of a polypeptide that can bind an outgrowth endothelial cell (OEC) or a circulating progenitor thereof to a subject in need thereof, wherein said polypeptide is conjugated to or complexed with said bioactive compound, wherein said polypeptide comprises the amino acid sequence selected from the group consisting of SEQ ID NO: 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, and 55, and variants thereof, wherein said variant differs from any one of SEQ ID NOs: 40-53 and 55 by one amino acid, and wherein said variant retains the ability to bind OEC or a circulating progenitor thereof.