Patent ID: 6239111
Filing Date: 2001-05-29
Classification: A61K,A61P

Abstract:
A method of inhibiting reduction in the survival rate of brain neurons which comprises contacting the neurons with an effective amount of a compound of the formula (I):CH.sub.2.dbd.CH--CH.sub.2 S(O).sub.n --R (I)wherein R represents a hydrogen atom; a C.sub.1-6 alkyl group optionally substituted with a hydroxyl, amino, carboxyl or halogen atom; a C.sub.2-6 alkenyl group optionally substituted with a hydroxyl, amino, carboxyl or halogen atom; a C.sub.1-6 alkylthio group optionally substituted with a hydroxyl, amino, carboxyl or halogen atom; a C.sub.2-6 alkenylthio group optionally substituted with a hydroxyl, amino, carboxyl or halogen atom; a phenyl group optionally substituted with a hydroxyl, amino, carboxyl, lower alkyl or halogen atom; a heterocyclic group selected from oxazolyl or benzoxazolyl; an amino acid residue selected from glycinyl, leucinyl, valinyl, alaninyl, phenylalaninyl, cysteinyl or homocysteinyl optionally having a protective group; an oligopeptide residue selected from alanyl-alanine, glutamyl-glycine or glutamyl-cysteinyl-glycine optionally having a protective group; a glycoside obtained by reacting a compound of the above formula (I) with saccharide; or salts of the above, wherein n is 0, 1 or 2.