Patent ID: 7642228
Filing Date: 2010-01-05
Classification: A61K,A61P,C07K

Abstract:
1. An isolated heteromultimer comprising at least a first polypeptide and a second polypeptide, wherein 1) the first polypeptide is associated with the second polypeptide via an interface, said interface having introduced therein at least one protuberance or cavity such that: (a) the interface of the first polypeptide comprises a protuberance that is positionable in a cavity in the iterface of the second polypeptide and/or (b) the interface of the first polypeptide comprises a cavity that accommodates a protuberance of the second polypepetide, such that a greater ratio of heteromultimer:homomultimer forms than for a multitimer having a wild-type interface, and 2) polypeptide interface via a CH3 constant damain of an antibody.