Patent ID: 6130227
Filing Date: 2000-10-10
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR6## wherein: R.sub.1 is --CN, --CH(CN)--R.sub.4, --CH.dbd.C(CN)--R.sub.4, --CH.sub.2 --CH(CN)--R.sub.4 --C(.dbd.NOH)--NH.sub.2, --C(.dbd.NH)--NH.sub.2, --CH.dbd.C(NO.sub.2)--R.sub.4, --CH(CN)--R.sub.5, --CH(CH.sub.2 NO.sub.2)--R.sub.5 ; 5-tetrazolyl, 2-(4,5-dihydrooxazolyl), 1,2,4-oxadiazolin-3-yl-5-one;R.sub.2 is hydrogen;R.sub.3 is hydrogen, OR.sub.6 ;R.sub.4 is hydrogen, C.sub.1 -C.sub.6 linear or branched alkyl, CN, COOR.sub.7 ;R.sub.5 is hydrogen, OR.sub.8 ;R.sub.6 is hydrogen, C.sub.1 -C.sub.6 linear or branched alkyl, (C.sub.6 -C.sub.12) aryl (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkyl (C.sub.6 -C.sub.12) aryl, (C.sub.6 -C.sub.12) aryl (C.sub.2 -C.sub.4) acyl, (C.sub.2 -C.sub.4) acyl, AMINO (C.sub.1 -C.sub.4) alkyl, amino (C.sub.2 -C.sub.4) acyl, glycosyl;R.sub.7 is hydrogen, C.sub.1 -C.sub.6 linear or branched alkyl, (C.sub.6 -C.sub.12) aryl (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkyl (C.sub.6 -C.sub.12) aryl;R.sub.8 has the same meanings of R.sub.6, independently of the latter;their N.sub.1 -oxides, their isomers, diastereoisomers, enantiomers and mixtures thereof.