Patent ID: 6903118
Filing Date: 2005-06-07
Classification: C07D,C07F

Abstract:
1. Pyridylalkane, pyridylalkene and pyridylalkine carboxamindes of formula (I) wherein: R R R R R k is 0 or 1; A is selected from the group consisting of C a substituted C C C a substituted C C a substituted C 1,3,5-hexatrienylene; a 1,3,5-hexatrienylene which is substituted by C ethinylene; D is selected from the group consisting of C a substituted C C a substituted C C a substituted C C E is wherein q is 1; R R and wherein R G is G1, wherein G r is 0, 1, 2 or 3; s is 0 or 1; R saturated or unsaturated four to eight-membered heterocycles which contain one or two hetero-atoms selected from the group consisting of N, S and O; benzyl, phenyl; monocyclic aromatic five or six-membered heterocycles which contain one to three hetero-atoms selected from the group consisting of N, S and O where the heterocycles are either bound directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrogenated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage may occur either over an aromatic or a hydrogenated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrogenated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms are selected from the group consisting of N, S and O and the linkage may occur either over an aromatic ring or a hydrogenated ring and either directly or over a methylene group; R R monocyclic aromatic five or six-member heterocycles, which contain one to three hetero-atoms selected from the group consisting of N, S and O and wherein the heterocycles are either bound directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrogenated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage occurs either over an aromatic or a hydrogenated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrogenated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms are selected from the group consisting of N, S and O and the linkage occurs either over an aromatic ring or a hydrogenated ring and either directly or over a methylene group; wherein G is not —(CH R R R A represents alkylene, substituted ethenylene or butadienylene; D represents alkylene or alkenylene; E represents piperazine or homopiperazine; and S is 1; wherein G is not phenyl, N-containing heteroaryl, —CH wherein the phenyl group or moiety may be substituted by one or two members selected from the group consisting of halogen, a C 1 -C 6 alkyl, trifluoromethyl and a C 1 -C 6 alkoxy, when R R R A is a C R D is a C E is selected from the group consisting of piperazine, piperazine, which is substituted by C