Patent ID: 6127383
Filing Date: 2000-10-03
Classification: A61P,C07D

Abstract:
A 2-aryl-substituted pyridine of the formula (I) ##STR198## in which A and E are identical or different and represent aryl having 6 to 10 carbon atoms, which is optionally substituted up to 3 times identically or differently by halogen, hydroxyl, trifluoromethyl, trifluoromethoxy or by straight-chain or branched alkyl, acyl, hydroxyalkyl or alkoxy each having up to 7 carbon atoms, or by a group of the formula --NR.sup.1 R.sup.2,in whichR.sup.1 and R.sup.2 are identical or different and denote hydrogen, phenyl or straight-chain or branched alkyl having up to 6 carbon atoms,D represents straight-chain or branched alkyl having up to 8 carbon atoms, which is substituted by hydroxyl,L represents cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or by hydroxyl,T represents a radical of the formula ##STR199## in which R.sup.3 and R.sup.4 are identical or different and denotewhich is optionally quinolyl, substituted up to 3 times identically or differently by trifluoromethyl, trifluoromethoxy, halogen, hydroxyl, carboxyl, nitro, by straight-chain or branched alkyl, acyl, alkoxy or alkoxycarbonyl each having up to 6 carbon atoms or by phenyl, phenoxy or phenylthio, which for their part can be substituted by halogen, trifluoromethyl or trifluoromethoxy,and/or optionally substituted by a group of the formula --NR.sup.7 R.sup.8,in whichR.sup.7 and R.sup.8 are identical or different and have the meaning of R.sup.1 and R.sup.2 indicated above,X denotes straight-chain or branched alkylene or alkenvlene each having up to 10 carbon atoms, each of which is optionally substituted up to 2 times by hydroxyl or halogen,R.sup.5 denotes hydrogen andR.sup.6 denotes hydrogen, mercapto, halogen, azido, trifluoromethyl, hydroxyl, trifluoromethoxy, straight-chain or branched alkoxy having up to 5 carbon atoms or a radical of the formula --NR.sup.9 R.sup.10,in whichR.sup.9 and R.sup.10 are identical or different and have the meaning ofR.sup.1 and R.sup.2 indicated above, orR.sup.5 and R.sup.6 together with the carbon atom form a carbonyl group, or a salt thereof.