Patent ID: 6831082
Filing Date: 2004-12-14
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula (Ia) wherein:R1 is pyridyl and R3 is CF3, halogen, CN, C1-8 alkyl or branched alkyl, C2-8 alkenyl or C3-8 branched alkenyl, C2-8 alkynyl or C3-8 branched alkynyl, C3-8 cycloalkyl optionally substituted with OH, CN or methoxy, C1-8 alkyloxy, C1-4 alkyloxyC1-4 alkyl, C1-8 alkylthio, C1-4 alkylthioC1-4alkyl, C1-8 dialkylamino, C1-4 dialkylaminoalkyl, CO2R5 where R5 is C1-4 alkyl or C2-4 alkenyl optionally substituted with carbocyclyl or heterocyclyl, aryl or is heterocyclyl optionally substituted with halogen, C1-4 alkyl, C2-4 alkenyl, CN, (CH3)2N, CO2CH3, alkyloxy, aryl, heterocyclyl or R5; R2 is H, halogen or methyl; L is â€”NHC(O) alkyl, R4 is pyridyl substituted with one or more â€”CN, â€”NO2, SO2NH2 alkylthio, alkylsulfinyl, alkylsulfonyl or R7 where R7 is phenyl, heterocyclyl, C3-6 cycloalkyl, C1-6 alkyl, C2-6 alkenyl, C1-6 alkyloxyalkyl, C1-4 alkyloxy, C1-5 alkylamino, C1-6 alkylthioalkyl, C1-6 alkylsulfinylalkyl or C1-6 alkylsulfonylalkyl, each R7 in turn is optionally substituted with halogen, OH, alkyloxy, CN, COO-lower alkyl, â€”CONH-lower alkyl, â€”CON(lower alkyl)2, dialkylamino, phenyl or heterocylcyl; R8 is NH2 or mono-or-diC1-5alkylamino; or the pharmaceutically acceptable salts thereof.