Patent ID: 8974795
Filing Date: 2015-03-10
Classification: A61K,C07D,C30B

Abstract:
1. A process for producing synthetic monodispersed hematin anhydride (HA) crystals doped with an antigen and/or an entity having a biological activity, said process comprising: a) providing a substantially pure iron(III) protoporphyrin-IX salt in an alkaline solution substantially free of oxygen; b) adjusting the pH of the solution of step a) from an initial pH to a final pH by slowly adding a medium strong organic acid, wherein the final pH is between about 4.0 and 4.5; c) during step b), adding the antigen and/or the entity at an intermediate pH of between about 5.0and 6.0; and d) incubating the solution obtained in step b) under conditions permitting annealing of HA crystals doped with the antigen and/or entity.