Patent ID: 6093798
Filing Date: 2000-07-25
Classification: C07K,C08F,Y02P

Abstract:
A solid phase reaction product comprising a solid substrate that is substantially insoluble in aqueous or organic reaction media, wherein the solid substrate comprises a base substrate carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups of formula (B): ##STR27## wherein P.sub.2 is hydrogen or a hydroxyl protecting group and the bond designated (a) is (i) cleavable under acid conditions or by photolysis and (ii) covalently links the group (B) to the base substrate via a linker group of formula (D): ##STR28## wherein the base substrate is directly linked to the linker group of formula (D) via a R.sub.13A, and the hydroxylamine group of formula (B) is directly linked to the linker group of formula (D) at *,wherein in formula (D):R.sub.11 and R.sub.11A independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, or phenyl optionally substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, nitrile or NO.sub.2 ;R.sub.12 and R.sub.12A independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, nitrile or NO.sub.2 ;R.sub.13A represents a bond or a group --(X.sup.1).sub.q --Y--, wherein q is 0 or 1; X.sup.1 represents --C(.dbd.O)--, --CH.sub.2 --, --CH.sub.2 C(.dbd.O)--, --O(CH.sub.2).sub.n C(.dbd.O)--, --O(CH.sub.2).sub.n C(.dbd.O)--(A.sup.1).sub.m --, or --O(CH.sub.2).sub.n C(.dbd.O)--(A.sup.1).sub.m --B.sup.1 --, wherein n is an integer from 1 to 6; m is 0 or 1; A.sup.1 represents --OCH(R.sup.1)--NH--, wherein R.sup.1 is the side chain of a natural or unnatural alpha amino acid, B.sup.1 represents a spacer group --NH(CH.sub.2).sub.p --, wherein p is 0 or an integer from 1 to 6; and Y represents --O-- or --NH--.