Patent ID: 6043279
Filing Date: 2000-03-28
Classification: C07C,C07D

Abstract:
A compound having the formula: ##STR14## wherein R.sub.1 and R.sub.2, each independently, represent hydrogen or lower alkyl or acyl having 1-4 carbon atoms;R' and R"" represent hydrogen, lower alkyl or acyl having 1-4 carbon atoms, OH, alkoxy having 1-4 carbon atoms, thiol or thio ether, or amino,or R' or R"" taken together form an oxo (keto), methano, thioketo, HO--N.dbd., NC--N.dbd., (R.sub.7 R.sub.8)N--N.dbd., R,.sub.7 O--N.dbd., R.sub.17 N.dbd., epoxy, cyclopropyl, or cycloalkyl group and wherein the epoxy, cyclopropyl, and cycloalkyl groups can be substituted with lower alkyl having 1-4 carbons or halogen;R.sub.6, R.sub.10, R.sub.11, R.sub.12, R.sub.13 each independently represent hydrogen, a lower alkyl having 1-4 carbons, halogen, nitro, OR.sub.7, SR.sub.7, NR.sub.7 R.sub.8 or (CF).sub.n CF.sub.3, and exist only if the Z, Z', Z"", Z'"", or Z"""" from which it originates is C, and where one of R.sub.6, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is X;R.sub.7 represents hydrogen or a lower alkyl having 1-6 carbons;R.sub.8 represents hydrogen or a lower alkyl having 1-6 carbons;R.sub.9 represents a lower alkyl having 1-4 carbons, phenyl, aromatic alkyl, or q-hydroxyphenyl, q-bromophenyl, q-chlorophenyl, q-fluorophenyl, or q-iodophenyl, where q=2-4;R.sub.17 represents hydrogen, lower alkyl having 1-8 carbons, alkenyl (including halogen, acyl, OR.sub.7 and SR.sub.7 substituted alkenes), R.sub.9, alkyl carboxylic acid (including halogen, acyl, OR.sub.7 and SR.sub.7 substituted alkyls), alkenyl carboxylic acid (including halogen, acyl, OR.sub.7 and SR.sub.7 substituted alkenes), alkyl amines (including halogen, acyl, OR.sub.7 and SR.sub.7 substituted alkyls), and alkenyl amines (including halogen, aryl, OR.sub.7 and SR.sub.7 substituted alkenes);R.sub.18 represents hydrogen, a lower alkyl having 1-4 carbons, halogan, nitro, OR.sub.7, SR.sub.7, NR.sub.7 R.sub.8, or (CF).sub.n CF.sub.3 ;X is COOH, tetrazole, PO.sub.3 H, SO.sub.3 H, CHO, CH.sub.2 OH, CONH.sub.2, COSH, COOR.sub.9, COSR.sub.9, CONHR.sub.9, or COOW where W is a pharmaceutically acceptable salt, and where X can originate from any C or N on the ring;Z, Z', Z"", Z""' and Z"""", each independently, represent C, S, O, N, or a pharmaceutically acceptable salt, but is not O or S if attached by a double bond to another such Z or if attached to another such Z which is O or S, and is not N if attached by a single bond to another such Z which is N; andn=0-3.