Patent ID: 6159968
Filing Date: 2000-12-12
Classification: A61K

Abstract:
A method for treating conditions which include as a symptom reduced permeability of chloride ions in cells comprising the administration to a person in need of such treatment of a safe and effective amount of a pharmaceutical composition comprising:(a) from about 0.001% to about 90% (w/w) of a benzimidazole derivative having the formula (I): ##STR3## wherein ring A is substituted with one or more substituents selected from the group consisting of hydrogen, chloro, methyl, ethyl, acetyl, methoxy, carbethoxy, and carbomethoxy; R3 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl and t-butyl; R4 is selected from the group consisting of straight and branched alkylene groups having one to four carbon atoms; R5 is selected from hydrogen, alkyl and alkoxy; R7 is selected from hydrogen, alkyl and alkoxy; R8 is hydrogen; R6 is hydrogen, chloro, methyl, ethyl, acetyl; methoxy, carbethoxy and carbomethoxy; and X is SO; and(b) from about 10% to about 99.999% of a pharmaceutically-acceptable carrier.