Patent ID: 6251887
Filing Date: 2001-06-26
Classification: A61P,C07J

Abstract:
A 17.beta.-aryl(arylmethyl)oxy(thio)alkyl-androstane derivative having the general formula [I] ##STR9##wherein R.sub.1 is (H,OR), (H,OSO.sub.3 H) or NOR, with R being H, (C.sub.1-6)alkyl or (C.sub.1-6)-acyl; each of R.sub.2 and R.sub.3 is independently hydrogen or (C.sub.1-6) alkyl; n is 0, 1 or 2; X is O, S, S(O).sub.2 ; m is 0 or 1; each of R.sub.4, R.sub.5 and R.sub.6 is independently hydrogen, hydroxy, (C.sub.1-4)alkoxy, halogen, NR.sub.7 R.sub.8 or (C.sub.1-4)alkyl and each of R.sub.7 and R.sub.8 is independently hydrogen or (C.sub.1-4)alkyl; and wherein the dotted lines indicate a .DELTA..sup.7 or a .DELTA..sup.8 double bond, or a pair of conjugated double bonds selected from .DELTA..sup.7,14, .DELTA..sup.8,14 and .DELTA..sup.6,8(14) ; or a pharmaceutically acceptable salt thereof.