Patent ID: 7838021
Filing Date: 2010-11-23
Classification: A61F,A61L

Abstract:
1. A method for producing a biological platform containing a pharmacologically active coating, said method comprising applying to at least a portion of a surface of a biological platform an inhibitor of synthesis of an extracellular matrix, of cell proliferation and migration, and of inflammation, to produce said biological platform containing a pharmacologically active coating, said inhibitor being a decorin peptide or biologically active fragment of decorin selected from the group consisting of (a) a decorin peptide comprising signal peptide and propeptide, (b) a 15-20 kDa biologically active fragment of decorin comprising amino acids 115 to 260 of decorin, (c) a biologically active fragment of decorin comprising a leucine-rich repeat, protein core (38-43 kDa) sequence of decorin and (d) a biologically active fragment of decorin comprising a decorin loop structure formed from cysteine residues.