Patent ID: 8546356
Filing Date: 2013-10-01
Classification: A61K,A61L,A61P,C08B

Abstract:
1. A coprecipitate comprising at least one complex and at least one insoluble calcium salt, said coprecipitate being in a divided form, said complex being in its insolubilized form and being a complex between an osteogenic protein selected from the group consisting of bone morphogenetic proteins and growth/differentiation factors, wherein the bone morphogenetic proteins and growth/differentiation factors are selected from the group consisting of BMP-2 (dibotermine-alpha), BMP-4, BMP-7 (eptotermine-alpha), BMP-14, GDF 5, and combinations thereof, and a functionalized dextran selected from the group consisting of dextrans comprising carboxyl functional groups partly substituted with hydrophobic alcohols, of general formula IX: in which q represents the mole fraction of carboxyl functions of the dextran that are substituted with F′—R-G-Ah and is between 0.01 and 0.7, F′ being an amide function, G being an ester, thioester, carbonate or carbamate function, R being a chain comprising between 1 and 18 carbons, optionally branched and/or unsaturated, optionally comprising one or more heteroatoms, and having at least one acid function, Ah being a hydrophobic alcohol residue, produced by coupling between a hydroxyl function of a hydrophobic alcohol and at least one electrophilic function borne by the group R, wherein when the carboxyl function of the dextran is not substituted with F′—R-G-Ah, then the carboxyl functional group(s) of the dextran are carboxylates of a cation, and wherein when the dextran comprises carboxyl functional groups, the dextran is amphiphilic at neutral pH.