Patent ID: 6809097
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound of the formula Id: wherein:G1c represents phenyl or 1H-indazol-6-yl; Y4c represents Câ€”H; Rfc represents hydrogen or fluoro; R2c represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; nc is an integer from 1 to 3; R1c represents hydrogen, hydroxy, methoxy, amino, nitro or halogeno; R3c represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylthio, or â€”NR6cR7c (wherein R6c and R7c, which may be the same or different, each represents hydrogen or C1-3alkyl), and additionally R3c may have any of the values of R5câ€”X1câ€” (wherein R5c and X1c are as defined below); R4c represents cyano, â€”NR8cR9c (wherein R8c and R9c, which may be the same or different, each represents C1-3alkyl), or a group R5câ€”X1c represents â€”OCOâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”CONR11c, â€”SO2NR12câ€” or â€”NR14câ€” (wherein R11c, R12c and R14c each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl), and R5c is selected from one of the following eight groups: 1) C1-5alkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy and amino; 2) C1-5alkylX2cCOR15c (wherein X2c represents â€”Oâ€” or â€”NR16câ€” (wherein R16c represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl) and R15c represents â€”NR17cR18câ€” or â€”OR19câ€” (wherein R17c, R18c and R19c which may be the same or different each represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl)); 3) C1-5alkylX3cR20c (wherein X3c represents â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”OCOâ€”, â€”NR21cCOâ€”, â€”CONR22c, â€”SO2NR23câ€”, â€”NR24cSO2â€” or â€”NR25câ€” (wherein R21c, R22c, R23c, R24c and R25c each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl) and R20c represents hydrogen, C1-3alkyl, cyclopentyl, cyclohexyl or a 5 or 6 membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which C1-3alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and C1-4alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy); 4) C1-5alkylX4cC1-5alkylX5cR26c (wherein X4c and X5c which may be the same or different are each â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”NR27cCOâ€”, â€”CONR28câ€”, â€”SO2NR29câ€”, â€”NR30cSO2â€” or â€”NR31câ€” (wherein R27c, R28c, R29c, R30c and R31c each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl) and R26c represents hydrogen or C1-3alkyl); 5) C1-5alkylR32c (wherein R32c is a 5 or 6 membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy); 6) (CH2)qcX6cR33c (wherein qc is an integer from 0 to 5, X6c represents a direct bond, â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”NR34cCO, CONR35c, â€”SO2N36câ€”, â€”NR37cSO2â€” or â€”NR38câ€” (wherein R34c, R35c, R36c, R37c and R38c each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl) and R33c is a phenyl group, a pyridone group or a 5 or 6 membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which phenyl, pyridone or aromatic heterocyclic group may carry up to 5 substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4alkoxy, C1-4hydroxyalkyl, C1-4hydroxyalkoxy, carboxy, cyano, â€”CONR39cR40c and â€”NR41cCOR42c (wherein R39c, R40c, R41c and R42c, which may be the same or different, each represents hydrogen or C1-4alkyl)); 7) C2-6alkenylR32c (wherein R32c is as defined above); and 8) C2-6alkynylR32c (wherein R32c is as defined above); or a salt thereof.