Patent ID: 6410733
Filing Date: 2002-06-25
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinX is O, CR6R6â€², NR6 or S, wherein R6 and R6â€² are independently H or alkyl; R1 is H, â€”OR7, an amino acid or â€”NR7R7â€², wherein R7 and R7â€² are independently H or a hydrocarbon chain, a carbocycle, a heterocycle, a carbocycle-substituted hydrocarbon chain or a heterocycle-substituted hydrocarbon chain optionally substituted with hydroxyl, halogen, cyano, amino, nitro, amidine, guanidine alkyl, halo-substituted alkyl, alkoxy, aryl or carboxyl; or R7 and R7â€² together form a heterocyle optionally fused to another heterocycle or carbocycle wherein said heterocycle and carbocycle are optionally substituted with hydroxyl, halogen, amino, nitro, amidine, guanidine, alkyl, halo-substituted alkyl, alkoxy or carboxyl; R2 is H or a hydrocarbon chain, a carbocycle or a carbocycle-substituted hydrocarbon chain optionally substituted with hydroxyl, oxo, halogen, cyano, amino, nitro, amidine, guanidine, alkyl, halo-substituted alkyl, alkoxy or carboxyl; and wherein said hydrocarbon chain is optionally interrupted with N, O, S, SO or SO2; R3 is H or a protecting group; R4 is selected from the group consisting of H, hydroxyl, halogen, amino, nitro, amidine, guanidine and acylamino; R5 is H or R4 and R5 together form a 5 or 6 member carbocycle or heterocycle ring optionally substituted with hydroxyl, halogen, amino, nitro, amidine, guanidine or acylamino; n is 0 or 1; or a salt, a solrate or a hydrate thereof.