Patent ID: 9079852
Filing Date: 2015-07-14
Classification: A61P,C07C,C07D

Abstract:
1. A method of treatment or reducing the symptoms of neuropathic pain, stroke, traumatic brain injury, epilepsy, and other neurologic events or neurodegeneration resulting from NMDA receptor activation comprising administering to a host in need thereof an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof: wherein: each L is independently C k=0, 1, 2, 3, 4 or5; each Ar W is a bond, C X is a bond, NR each R each R n=1, 2, 3 or 4; p=2, 3 or 4; each R or wherein —NR Y is a bond, O, S, SO, SO Z is OH, NR  wherein R wherein when X is a bond, Y is O and Ar when X is O,—NR optionally in a pharmaceutically acceptable carrier; wherein other neurologic events or neurodegeneration resulting from NMDA receptor activation are selected from the group consisting of Parkinson's disease, Alzheimer's disease, Huntington's chorea, Amyotrophic Lateral Sclerosis, ischemic injury, hypoxia, pre-eclampsia, spinal cord trauma, status epilepticus, inflammatory pain, chronic pain, vascular dementia, glioma tumors, acidification of brain or spinal cord tissue, and head trauma.