Patent ID: 6242470
Filing Date: 2001-06-05
Classification: A61P,C07C,C07D

Abstract:
A compound of general formula ##STR63##wherein A represents a CH.sub.2 group;B represents a hydrogen or halogen atom;D represents a group CH.sub.2, OCH.sub.2, NHCH.sub.2 or CH.sub.2 CH.sub.2 ;R represents a phenyl group, which may be optionally substituted by one or more substituents independently selected from a halogen atom or a cyano, carboxyl, hydroxyl, nitro, halo-C.sub.1 -C.sub.6 -alkyl, --N(R.sup.1)--C(.dbd.O)--R.sup.2, --C(O)NR.sup.3 R.sup.4, --NR.sup.5 R.sup.6, C.sub.3 -C.sub.8 -cycloalkyl, 3- to 8-membered heterocyclyl, C.sub.3 -C.sub.8 -cycloalkyloxy, C.sub.1 -C.sub.6 -alkylcarbonyl, phenoxy, benzyl, C.sub.1 -C.sub.6 -alkylthio, phenylthio, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.6 -alkylsulphinyl or C.sub.1 -C.sub.6 -alkylsulphonyl group, or a C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy group optionally substituted by one or more substituents independently selected from a halogen atom or an amino, carboxyl, hydroxyl, C.sub.1 -C.sub.6 -alkoxy, (di)C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -alkoxycarbonyl, imidazolyl, morpholinyl, piperldinyl or pyrrolidinyl group;R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;R.sup.2 represents a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group; andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently represent a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.8 -cycloalkyl group;with the provisos that (i) when A is CH.sub.2, B is H and D is CH.sub.2, then R does not represent a phenyl, ortho-carboxyphenyl, ortho-nitrophenyl, ortho-aminophenyl, ortho-(dimethylaminoethyl)phenyl, methylphenyl or para-phenoxyphenyl group, and (ii) when A is CH.sub.2, B is Br and D is CH.sub.2, then R does not represent an orthocarboxyphenyl group, and (iii) when A is CH.sub.2, B is H and D is CH.sub.2 CH.sub.2, then R does not represent a phenyl group, and (iv) when A is CH.sub.2 D is CH.sub.2 or CH.sub.2 CH.sub.2 and R represents a substituted phenyl group, the substituent or substituents present do not comprise, in an ortho position, a C.sub.1 -C.sub.6 -alkoxy group substituted by an amino, (di)C.sub.1 -C.sub.6 -alkylamino, imidazolyl, morpholinyl, piperidinyl or pyrrolidinyl group;or a pharmaceutically acceptable salt or solvate thereof.