Patent ID: 6455286
Filing Date: 2002-09-24
Classification: A61L,A61M,A61P,C07D,C12N

Abstract:
A method of treating a biological composition suspected of containing a pathogen, comprising, in the following order:a) providing, in any order, i) a compound of the formula selected from the group consisting of wherein:I) a substituent A on the pyrone ring is selected from the group consisting of: â€”(CH2)uâ€”NH2, â€”(CH2)wâ€”Jâ€”(CH2)zâ€”NH2, â€”(CH2)wâ€”Jâ€”(CH2)xâ€”Kâ€”(CH2)zâ€”NH2, and â€”(CH2)wâ€”Jâ€”(CH2)xâ€”Kâ€”(CH2)yâ€”Lâ€”(CH2)zâ€”NH2; wherein J, K, and L are independently selected from the group consisting of O and NH, in which u is a whole number from 1 to 10, w is a whole number from 1 to 5, x is a whole number from 2 to 5, y is a whole number from 2 to 5, and z is a whole number from 2 to 6; andII) substituents B, R3, R4, R5, and R6 on the pyrone ring, 5-, 4â€²-, 5â€²- and 8-carbon atoms respectively, are independently selected from the group consisting of â€”H and â€”(CH2)vCH3, where v is a whole number from 0 to 5; and all salts thereof; ii) a light source for photoactivating said compound; and iii) a biological composition suspected of containing a pathogen; b) adding said compound to said biological composition; and c) photoactivating said compound, so as to inactivate said pathogen.