Patent ID: 8986657
Filing Date: 2015-03-24
Classification: C07D,C07F,G01N

Abstract:
1. A method for detecting soluble amyloid beta in a sample, comprising: (a) contacting a sample comprising soluble amyloid beta with a compound having the formula Ar L is a divalent linking group comprising an alkenylene having 5 to 15 backbone carbon atoms, wherein at least two of the backbone carbon atoms form part of a difluoroboronate ring, and Ar wherein said compound binds soluble amyloid beta in the sample; (b) illuminating said compound bound to the soluble amyloid beta with near infrared light of a wavelength absorbable by said compound; and (c) detecting fluorescence emitted by the compound wherein said fluorescence corresponds to the soluble amyloid beta contained in said sample.