Patent ID: 6096862
Filing Date: 2000-08-01
Classification: A61K,A61P,C07K,Y02A

Abstract:
A multimeric antiviral agent comprising two or more monomers selected from the group consisting of monomeric transmembrane intercellular adhesion molecule-1(tmICAM-1) and monomeric fragments of tmICAM-1, with thc proviso that when said multimer is a dimer said monomers cannot both be tmICAM-1, wherein each of said monomers comprises the human rhinovirus (HRV) binding site and retains the ability to bind to HRV and reduce infectivity thereof, and wherein said multimeric antiviral agent mimics the multimeric configuration of tmICAM-1 and exhibits enhanced binding to said HRV relative to at least one of the constituent monomers.