Patent ID: 6048521
Filing Date: 2000-04-11
Classification: A61K,A61L,B01J,C08G,C40B

Abstract:
The controlled drug delivery system comprising a biologically or pharmaceutically active compound physically coated with a random block copolymer having the formula: ##STR4## wherein R.sub.1 is --CH.dbd.CH-- or (--CH.sub.2 --).sub.j, in which j is zero or an integer from one to eight; R.sub.2 is selected from the group consisting of straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and optionally containing at least one ether linkage, and derivatives of biologically and physiologically active compounds covalently bonded to said copolymer;each R.sub.3 is independently an alkylene group containing up to 4 carbon atoms;A is selected from the group consisting of: ##STR5## wherein R.sub.8 is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;y is between about 5 and about 3000; andf is the percent molar fraction of alkylene oxide in said copolymer and ranges between about 1 and about 99 mole percent.