Patent ID: 7112685
Filing Date: 2006-09-26
Classification: A61P,C07D

Abstract:
1. A method for preparing a labeled resiniferatoxin derivative compound of Formula (V): wherein R R protecting the carboxylic acid of an intermediate compound of Formula (VI); wherein the hydroxyl group of the compound of Formula (VI) is esterified with C 1-5 alkyl to form an esterified intermediate compound of Formula (VII); stannylating the compound of Formula (VII) to form a stannylated intermediate compound of Formula (VIII); iodinating the compound of Formula (VIII) to form a labeled intermediate compound of Formula (IX); deprotecting the compound of Formula (LX) to form a labeled intermediate compound of Formula (X); and, coupling the labeled intermediate compound of Formula (X) with a resiniferonal orthophenylacetate alcohol compound of Formula (IV); to form the compound of Formula (V).