Patent ID: 6232348
Filing Date: 2001-05-15
Classification: A61P,C07C

Abstract:
An oral pharmaceutical composition suitable for the treatment of cardiovascular diseases, comprising a therapeutically effective amount of a compound of formula (II) ##STR11##whereinr is an integer selected from 5, 6 and 7;s is an integer selected from 2 and 3;A is O or a single bond;R'.sub.4, R'.sub.5 and R'.sub.6, the same or different, are hydrogen, OH, halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, NH.sub.2, mono- or di-C.sub.1 -C.sub.4 alkylamino, SH, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, NHCHO, C.sub.1 -C.sub.4 alkycarbonyl-amino, NHCONH.sub.2, C.sub.1 -C.sub.4 alkylsulfonylamino, C.sub.1 -C.sub.4 alkylaminosulfonyl, SO.sub.2 NH.sub.2, NHSO.sub.2 NH.sub.2, COOH, SO.sub.3 H, CONH.sub.2, CH.sub.2 OH, or phenyl; orR'.sub.4 and R'.sub.5, in ortho position relative to each other, together form a chain of 3 or 4 groups selected from CT'T"", CO, S, O and NT'"", wherein T' is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, T"" is a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an amino group and T'"" is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; or T' together with a neighbouring T"" or T'"" forms a single bond, or T'"" together with a neighbouring T' or T'"" forms a single bond;the asterisk marks an asymmetric carbon atom;or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable carrier.