Patent ID: 9095516
Filing Date: 2015-08-04
Classification: A61J,A61K

Abstract:
1. A process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of: providing a fluid formulation comprising the medicinal substance, a crystalline carrier material that is solid at room temperature and a gelator, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation after said cooling, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, wherein the volume of the cavity is smaller than 50% of the volume of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet.