Patent ID: 9186369
Filing Date: 2015-11-17
Classification: A61K,A61P,C07H

Abstract:
1. A method of treating a host infected with HCV, comprising administering an effective amount of a ribofuranonucleoside of Formula (I): or a pharmacologically acceptable salt thereof, wherein: R is H, mono-, di-, or triphosphate; or phosphonate; X is O, S(O) n is 0-2; such that when X is CH then each R such that when X is O, S(O) then each R each R R R Base is selected from the group consisting of: wherein each R′ and R″ independently is H, C each W is Cl, Br, I, F, halogenated alkyl, alkoxy, OH, SH, O-alkyl, S-alkyl, O-alkenyl, O-alkynyl, S-alkenyl, S-alkynyl, —OC(O)NR each Z is O, S, or NH.