Patent ID: 6803456
Filing Date: 2004-10-12
Classification: A61K,C07C,C07H

Abstract:
A process of making a complex of (a) arginine, (b) a silicate, and (c) at least one polyol selected form the group consisting of inositol and sugar alcohols, comprising(i) preparing a first solution comprising a pharmaceutically acceptable salt of said silicate, said polyol, and water at an elevated temperature of at least about 30Â° C.; (ii) adding to said first solution said arginine to form a first mixture; (iii) heating said first mixture to a temperature of at least 80Â° C. to form a second solution; and (iv) spray drying said second solution (A) without allowing said second solution to gel crystallize; or (B) after reheating said second solution to at least about 55Â° C. if said second solution has cooled sufficiently to begin crystallization.