Patent ID: 7977427
Filing Date: 2011-07-12
Classification: A61K,A61P,C08G

Abstract:
1. A method comprising: (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups; and (ii) reacting the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups with a water-soluble and non-peptidic polymer having three or more primary amino groups under conditions effective to form a cross-linked polymer composition, wherein the water-soluble and non-peptidic polymer within each of (a) the water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups, (b) the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups, and (c) the water-soluble and non-peptidic polymer having three or more primary amino groups is independently selected from the group consisting of poly(alkylene glycol), poly(oxyethylated polyol), poly(olefinic alcohol), poly(vinylpyrrolidone), poly(hydroxypropylmethacrylamide), poly(α-hydroxy acid), poly(vinyl alcohol), polyphosphazene, polyoxazoline, and poly(N-acryloylmorpholine).