Patent ID: 6204064
Filing Date: 2001-03-20
Classification: G01N,Y10T

Abstract:
A method for quantitatively measuring the progression of a lesion, said method comprising the steps of:a. preparing a clinical sampled section of a current biopsied lesion;b. magnifying the sampled section of the current biopsied lesion;c. forming a video image of the magnified sampled section with a video camera;d. digitizing the video image formed by the video camera;e. storing the digitized video image electronically;f. analyzing the stored digitized video image to locate a plurality of cell nuclei within said digitized video image;g. computing at least one chromatin texture feature of a predetermined type of each of said plurality of cell nuclei; andh. comparing the at least one computed chromatin texture feature of the plurality of nuclei from the current biopsied lesion to a range of previously computed chromatin texture features of the same predetermined type for lesions that range along a progression curve from normal tissue to malignant disease, in order to measure the degree to which the current lesion has progressed from normal tissue toward malignant disease.