Patent ID: 6265537
Filing Date: 2001-07-24
Classification: A61P,C07D

Abstract:
Cyclic thiodepsipeptides of the formula (I) and salts thereof ##STR22##in whichR.sup.1, R.sup.4, R.sup.7 and R.sup.10 each represent independently of one another hydrogen, straight-chain or branched C.sub.1-4 -alkyl, andR.sup.2, R.sup.5, R.sup.8 and R.sup.11 each represent independently of one another hydrogen, straight-chain or branched C.sub.1-8 -alkyl, C.sub.1-8 -alkenyl, C.sub.3-6 -cycloalkyl, C.sub.3-6 -cycloalkyl-C.sub.1-2 alkyl, aryl-C.sub.1-2 -alkyl, hetaryl-C.sub.1-2 -alkyl, aryl or hetaryl, selected from the group consisting of benzyl, furyl and pyridinyl groups, each of which is optionally substituted, andR.sup.9 and R.sup.10 together with the atoms that they are attached to represent a 5- or 6-membered ring which may optionally be substituted, andR.sup.10 and R.sup.11 together with the atoms that they are attached to represent a 5-, 6- or 7-membered ring which may optionally be interrupted by oxygen, sulfur, sulfoxy or sulfonyl which ring is a member of cyclic amino groups having saturated and unsaturated monocyclic groups with a nitrogen atom as heteroatom selected from the group consisting of 1-azetidinyl, pyrrolidino, 2-pyrrolin-1-yl, 1-pyrrolyl, piperidino, 1,4-dihydropyrazin-1-yl, 1,2,5,6-tetrahydropyrazin-1-yl, 1,4-dihydropyridin-1-yl, 1,2,5,6-tetrahydropyridin-1-yl or homopiperidinyl; a member of cyclic amino groups having saturated and unsaturated monocyclic groups with two or more nitrogen atoms as heteroatoms selected from the group consisting of 1-imidazolidinyl, 1-imidazolyl, 1-pyrazolyl, 1-triazolyl, 1-tetrazolyl, 1-piperazinyl, 1-homopiperazinyl, 1,2-dihydropyridazin-1-yl, 1,2-dihydropyrimidin-1-yl, perhydropyrimidin-1-yl and 1,4-diazacyclo-heptan-1-yl; a member of cyclic amino groups having saturated and unsaturated monocyclic groups with one or two oxygen atoms and one to 3 nitrogen atoms as heteroatoms selected from the group consisting of oxazolidin-3-yl, 2,3-dihydroisoxazol-2-yl, isoxazol-2-yl, 1,2,3-oxadiazin-2-yl and morpholino; a member of cyclic amino groups having saturated and unsaturated monocyclic groups with one to three nitrogen atoms and one to two sulfur atoms as heteroatoms selected from the group consisting of thiozolidin-3-yl, isothiazolin-2-yl, thiomorpholino, or dioxothiomorpholino; a member of cyclic amino groups having saturated and unsaturated fused cyclic groups selected from the group consisting of indol-1-yl, 1,2-dihydrobenzimidazol-1-yl and perhydropyrrolo[1,2-a]pyrazin-2-yl; a member of cyclic amino groups having spirocyclic groups selected from the group consisting of 2-azaspiro[4.5]decan-2-yl; a member of cyclic amino groups having bridged heterocyclic groups selected from the group consisting of 2-azabicyclo[2.2.1]heptan-7-yl, which may optionally be substituted, andR.sup.3 and R.sup.9 each represent independently of one another hydrogen, C.sub.1-8 -alkyl or aryl-C.sub.1-2 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-2 -alkyl, andR.sup.6 and R.sup.12 each represent independenty of one another hydrogen, straight-chain or branched C.sub.1-8 -alkyl, C.sub.1-8 -alkenyl, C.sub.3-6 -cycloalkyl, C.sub.3-6 -cycloalkyl-C.sub.1-2 -alkyl, aryl-C.sub.1-2 -alkyl, hetaryl-C.sub.1-2 -alkyl, aryl or hetaryl, cycloalkyl-C.sub.1-2 -alkyl, aryl-C.sub.1-2 -alkyl, hetaryl-C.sub.1-2 -alkyl, aryl or hetaryl, selected from the group consisting of benzyl, furyl and pyridinyl groups each of which is optionally substituted, andX.sup.1, X.sup.2, X.sup.3 and X.sup.4 each represent independently of one another oxygen or sulfur, it being necessary for at least one of the radicals X.sup.1, X.sup.2, X.sup.3 and X.sup.4 of the thiodepsipeptide to represent sulfur,and their optical isomers and racemates.