Patent ID: 6294558
Filing Date: 2001-09-25
Classification: C07D

Abstract:
A compound of the formula: ##STR20##or its pharmaceutically acceptable salt thereof, whereinA is partially unsaturated or unsaturated five membered heterocyclic, wherein the 4-(sulfonyl)phenyl and the 4-substituted phenyl in the formula (I) are attached to ring atoms of Ring A adjacent to each other;R.sup.1 is heteroaryl, and the heteroaryl being optionally substituted by one to four substituents selected from halo, C.sub.1-4 alkyl, halo-substituted C,.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkyl carbonyl, hydroxy, nitro, cyano and amino;R.sup.2 is C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, C.sub.1-4 alkylamino, C.sub.1-4 dialkylamino or amino; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen, halo, C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkynyl, C.sub.1-4 alkoxy, hydroxy-C.sub.1-4 alkyl, C.sub.1-4 alkoxy C.sub.1-4 alkyl, C.sub.1-4 alkanoyl, cyano, nitro, cyano C.sub.1-4 alkyl, carboxy, C.sub.1-4 alkoxycarbonyl, aminocarbonyl, N--C.sub.1-4 alkylaminocarbonyl, N,N-di-C.sub.1-4 alkylaminocarbonyl, N-arylaminocarbonyl, N,N-diarylaminocarbonyl, N--C.sub.1-4 alkyl-N-arylaminocarbonyl, aryl, aryloxy, aryloxy-C.sub.1-4 alkyl, heteroaryl, heteroaryloxy, heteroaryloxy-C.sub.1-4 alkyl, morpholino-carbonyl, C.sub.1-4 alkoxyaminocarbonyl or C.sub.1-4 alkyl-carbonylamino; or two of R.sup.3, R.sup.4 and R.sup.5 are taken together with atoms to which they are attached and form a 4-7 membered ring;R.sup.6 and R.sup.7 are independently hydrogen, halo, C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylamino, N,N-di C.sub.1-4 alkylamino, hydroxyl-C.sub.1-4 alkyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, C.sub.1-4 alkyl-C.sub.1-4 alkoxy, C.sub.1-4 alkylamino-C.sub.1-4 alkyl, hydroxy, amino-C.sub.1-4 alkyl and N,N-di C.sub.1-4 alkylamino-C.sub.1-4 alkyl; andm and n are independently 1, 2, 3 or 4,with the proviso that when A contains an oxygen or sulfur heteroatom, one of R.sup.3, R.sup.4 or R.sup.5 is absent.