Patent ID: 6160124
Filing Date: 2000-12-12
Classification: C07D

Abstract:
A malonate compound of the formula (XIV) ##STR391## wherein R is a phenyl, biphenyl or naphthyl, which is optionally substituted by 1 to 3 substituents; an alicyclic hydrocarbon having 3 to 7 carbon atoms, which is optionally substituted by 1 to 3 substituents; a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms, which is optionally substituted by 1 to 3 substituents; a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms, which is condensed with a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms, or condensed with a 4-, 5- or 6-membered aromatic hydrocarbon, which is optionally substituted by 1 to 3 substituents; or a group of the formula ##STR392## wherein R.sub.1 is a phenyl, biphenyl or naphthyl, which is optionally substituted by 1 to 3 substituents; an alicyclic hydrocarbon having 3 to 7 carbon atoms, which is optionally substituted by 1 to 3 substituents; a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms, which is optionally substituted by 1 to 3 substituents; a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms which is condensed with a 5- or 6-membered heterocyclic group having 1 to 3 hetero atoms, or condensed with 4-, 5- or 6-membered aromatic hydrocarbon, which is optionally substituted by 1 to 3 substituents; said hetero atoms being an atom selected from sulfur atom, oxygen atom and nitrogen atom; R.sub.2 and R.sub.3 are the same or different and each is a hydrogen atom or a C.sub.1-4 alkyl, and 'X is an oxygen atom, a sulfur atom or a secondary aminoR.sub.4 is a hydrogen atom or a C.sub.1-4 alkyl;R.sub.5 is a C.sub.1-4 alkyl; andR.sub.7 is a C.sub.1-4 alkyl;said substituents being a group selected from hydroxyl, a C.sub.1-4 alkyl and a C.sub.1-4 alkoxyl; ora pharmaceutically acceptable salt thereof.