Patent ID: 6054114
Filing Date: 2000-04-25
Classification: A61K,C07B,C07F

Abstract:
An amyloid binding compound of the formula: ##STR70## and pharmaceutically acceptable salts thereof; wherein.J is selected from the group consisting of NH, O antl S;T is selected from the group consisting of CO and CH.sub.2 ;n is a number selected from the group of 1, 2, 3, 4, 5 and 6;M is selected from the group consisting of .sup.99m Tc, .sup.111 In, .sup.90 Y, .sup.99 Tc and .sup.186 Re;L and L' are independently selected from the group consisting of --N.dbd.N--, --CONH--, --NHCO--, --HN--NH--, and --C.dbd.C--;andAr and Ar' are independently selected from the group consisting of: ##STR71## wherein each of the groups designated V, W, Q, Y, Z, A and B is ind pendenti selected from the group consisting of:OH, COOH, H, R.sup.5 (wherein R.sup.5 is a C.sub.1-6 hydrocarbon), CO.sub.2 R.sup.6 (wherein R.sup.6 is a C.sub.1-6 hydrocarbon), CONH.sub.2, CN, NH.sub.2, CH.sub.2 NH.sub.2 and SO.sub.3.