Patent ID: 6200988
Filing Date: 2001-03-13
Classification: A61P,C07D

Abstract:
A hetero cyclic compound of the formula (I) ##STR40##whereinone of R.sup.1, R.sup.2 and R.sup.5 is hydroxy, carboxy, alkoxycarbonyl, a group of the formula --NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are each independently hydrogen atom or lower alkyl, or alkyl or alkenyl substituted by hydroxy, carboxy, sulfonic acid, phosphoric acid group, alkoxycarbonyl or a group of the formula --NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are each independently hydrogen atom or lower alkyl, and the other two are each independently hydrogen atom, lower alkyl or lower alkoxy;either R.sup.3 or R.sup.4 is a group of the formula --NHCOR.sup.7 wherein R.sup.7 is alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group of the formula --NER.sup.8 wherein R.sup.8 is alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, and the other is hydrogen atom, lower alkyl or lower alkoxy;R.sup.6 is alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl or arylalkyl,provided that when one of R.sup.1 and R.sup.2 is alkoxy the other should not be alkyl substituted by a group of the formula --NR.sup.9 R.sup.10 ;or a pharmaceutically acceptable salt thereof.