Patent ID: 6495592
Filing Date: 2002-12-17
Classification: A61K,A61P,C07D,Y10S

Abstract:
A method for relaxing tracheal smooth muscle in an asthmatic subject comprising administering to said subject in need thereof an effective amount of a compound represented by formula (1): whereinX and Y each is any member selected from the group consisting of CH2, CHW1, where W1 is a halogen atom, a hydroxyl group or a lower alkoxy group and C&boxH;O when the bond between X and Y is a single bond while, when the bond between X and Y is a double bond, X and Y each is any member selected from the group consisting of CH and COW2, where W2 is a lower alkyl group or a lower alkylcarbonyl group; Z is O; and R1-R8 each is selected from the group consisting of a hydrogen atom, VR9, where V is O, S, S&boxH;O or SO2; and R9 is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a lower acyl group, a trihalomethyl group or a carboxyl lower alkyl group; a hydroxy lower alkynyl group, a hydroxy lower alkenyl group, a halogen atom, a lower alkyl group, a trihalomethyl group, a trimethylsilylethynyl group, a nitro group, an amino group, an N-carbonyl lower alkyl group, a lower alkylphenyl group and a phenyl group or a pharmaceutically acceptable salt thereof.