Patent ID: 6596738
Filing Date: 2003-07-22
Classification: A61P,C07D,C07F,Y02P

Abstract:
A compound of formula (I) or a salt thereof: wherein B is: wherein X and R1 are both hydrogen, and R2 is hydrogen or lower alkyl; wherein X is hydrogen, and R1 and R2 are independently hydrogen or lower alkyl; A is ethylene; W is N-containing heterobicyclic group or aryl, each of which may have one or more substituent(s)selected from the group consisting of cyano, hydroxy, halogen, oxo, optionally substituted lower alkoxy, lower alkyl, optionally substituted amino, nitro and â€”NHâ€”C(O)â€”R3, wherein R3 is lower alkyl, optionally substituted ar(lower)alkyl, ar(lower)alkylamino, aryl, heterocyclic(lower)alkyl, or heterocyclicthio(lower)alkyl, each of which may have one or more substituent(s); and Z is imidazolyl, which may have one or two substituent(s) selected from the group consisting of carbamoyl, N-substituted carbamoyl, lower alkoxycarbonyl and guanidinocarbonyl, provided that when W is aryl, which may have two or more substituent(s), then Z is imidazolyl which may have one or more substituent(s) and R1 and R2 are both lower alkyl.