Patent ID: 6090953
Filing Date: 2000-07-18
Classification: A61K,C07C,C07D,C07F

Abstract:
A process of preparing a myxopyronin having the structure: ##STR40## which comprises: (a) reacting an acyl pyrone having the structure: ##STR41## with an unsaturated aldehyde having the structure: ##STR42## to form a pyrone aldol having the structure: ##STR43## (b) (i) mesylating the pyrone aldol formed in step (a) to form a pyrone aldol mesylate; and(ii) reacting the pyrone aldol mesylate formed in step (b) (i) to form a pyrone diene having the structure: ##STR44## and (c) saponifying the pyrone diene formed in step (b) (ii) to form a pyrone acid;(d) converting the pyrone acid formed in step (c) to a pyrone acyl azide; and(e) solvolyzing the pyrone acyl azide formed in step (d) with methanol to form the myxopyronin.