Patent ID: 6011026
Filing Date: 2000-01-04
Classification: A61K,A61P

Abstract:
A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR6## wherein n is 2 or 3, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms or taken together with the nitrogen atom to which they are attached form aromatic or non-aromatic, saturated or unsaturated, mono or polycyclic heterocycles of 5 to 15 ring members optionally containing in the ring up to 3 heteroatoms selected from the group consisting of oxygen, sulfur and optionally substituted nitrogen, X is optionally esterified hydroxy and Y is selected from the group consisting of hydrogen and alkenyl and alkynyl of 2 to 4 carbon atoms or X and Y form .dbd.O or X and Y together with the carbon atom to which they are attached form a member selected from the group consisting of ##STR7## and their non-toxic, pharmaceutically acceptable acid addition salts sufficient to treat menopause or perimenopause symptoms without estrogenic activity at the uterine level.