Patent ID: 6541471
Filing Date: 2003-04-01
Classification: A61P,C07C,C07D

Abstract:
A compound of formula (I): wherein:G represents a group: wherein R1 and R2 independently represent a hydrogen atom, or an alkyl, cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl group, or R1 and R2 together with the nitrogen atom form a heterocycloalkyl group of formula â€ƒhaving from 5 to 7 ring members, wherein Y represents a nitrogen atom, an oxygen atom or a CH2 group and R6 represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylcarbonyl, optionally substituted arylcarbonylalkyl, optionally substituted diarylalkyl, optionally substituted diarylalkenyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroaryl-carbonyl or optionally substituted heteroarylcarbonylalkyl group, R3 represents a hydrogen atom or an alkyl or optionally substituted phenyl group, Ra represents a hydroxy, alkoxy, optionally substituted aryloxy, optionally substituted arylalkyloxy, amino, alkylamino, dialkylamino, optionally substituted arylamino or optionally substituted arylalkylamino group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, m is an integer of from 0 to 1 inclusive, n and q are identical or different integers of from 0 to 6 inclusive, p and r are identical or different integers of from 1 to 6 inclusive, its enantiomers, diastereoisomers, or an addition salt thereof with a pharmaceutically acceptable acid or base, wherein:the term â€œalkylâ€  denotes a linear or branched chain having from 1 to 6 carbon atoms, the term â€œalkoxyâ€  denotes a linear or branched alkyl-oxy group having from 1 to 6 carbon atoms, the term â€œtrihaloalkylâ€  denotes a carbon chain having from 1 to 3 carbon atoms and from 1 to 3 identical or different halogen atoms, the term â€œalkenylâ€  denotes a chain having from 2 to 6 carbon atoms and containing from 1 to 3 double bonds, the term â€œcycloalkylâ€  denotes a saturated cyclic group having from 3 to 8 carbon atoms, the term â€œarylâ€  denotes a phenyl or naphthyl group, the term â€œheteroarylâ€  denotes an aromatic monocyclic group, or a bicyclic group in which at least one of the rings is aromatic, having from 5 to 11 ring members and from 1 to 5 hetero atoms selected from nitrogen, oxygen and sulphur, the terms â€œdiarylalkylâ€  and â€œdiarylalkenylâ€  denote, respectively, alkyl and alkenyl groups as defined hereinbefore, substituted by two identical or different aryl groups as defined hereinbefore, the term â€œsubstitutedâ€  relating to phenyl, aryl, arylalkyl, arylcarbonyl, arylcarbonylalkyl, diarylalkyl, diarylalkenyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heteroarylcarbonylalkyl, arylamino and arylalkylamino denotes that the groups are substituted in the aromatic moiety by one or two identical or different substituents selected from halogen atoms and alkyl groups, alkoxy groups, hydroxy groups, cyano groups, nitro groups, amino groups (optionally substituted by one or two alkyl groups) and groups C(O)Rd, Rd representing a group selected from hydroxy, alkoxy and amino, wherein the heteroaryl and heteroarylalkyl groups may also be substituted by an oxo group on the non-aromatic moiety of the heteroaryl.