Patent ID: 7741277
Filing Date: 2010-06-22
Classification: A61P,C07D,C07K,C12P

Abstract:
1. A compound of the formula (I) or (IV): wherein for (I) and (IV) A is a disorazole moiety according to formula (III): wherein Rio, Rjo, Rkp, Rmp, R28, R30, R31, R32 R33, R34, R35, R36, R38, R40, R41, R42, R43 and R44 are hydrogen; R1p and Rnp together form a double bond or are independently selected from the group consisting of hydrogen and alkoxyl; R27 and R29 together form a double bond or an epoxide (oxiran); R37 and R39 together form a double bond or an epoxide (oxiran); R25 and R26 are independently from each other selected from the group consisting of: alkyl which is optionally substituted in the alkyl group by 1, 2 or 3 substituents independently from each other selected from the group consisting of alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, heteroaryl, aryl-alkyl, heteroaryl-alkyl, heterocyclyl, heterocyclyl-alkyl, alkylsulfonyl, arylsulfonyl, aryl-alkylsulfonyl, halogen, —F, —Cl, —Br, —I, —N B1 and B2 are independently from each other selected from the group consisting of dicarbonic acid residue linker, succinyl and glutaryl; C1 and C2 are independently from each other selected from the group consisting of luteinizing hormone releasing hormone (LHRH), [D-Lys o is 1 or 2; and p is 1 or 2.