Patent ID: 8404805
Filing Date: 2013-03-26
Classification: A61K,A61P,C07K

Abstract:
1. A method for detecting a complex comprising GRP94 in a sample suspected of containing a complex comprising GRP94, the method comprising: (a) contacting the sample with a binding substance that preferentially binds GRP94 under conditions favorable to binding a complex comprising GRP94 to the binding substance to form a second complex there between; and (b) detecting the second complex via a label conjugated to the binding substance or via a labeled reagent that specifically binds to the second complex subsequent to its formation, wherein the binding substance comprises a compound of formula (I): or a compound of formula (II): and further wherein: X and Y are the same or different and X and Y═C, N, O or S; and X and Y can be substituted with hydrogen, hydroxyl, or oxygen, including double-bonded oxygen; R R R R