Patent ID: 6559155
Filing Date: 2003-05-06
Classification: A61P,C07D

Abstract:
A compound of formula (I): in which:R1 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH; R2 is phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazolyl, furanyl, thienyl, thiazolyl, quinolyl, benzothiazolyl, pyridazolyl or pyrazinyl each of which may be unsubstituted or substituted by 1, 2, 3 or 4 substituents selected from C1-4alkyl, C1-4alkoxy, C1-4alkylthio, aryl, aralkyl, hydroxy, oxo, halogen, CN, COOH or a salt thereof, COOâ€”C1-6alkyl, CONR15R16, NR15COR16, SO2NR15R16, NR15SO2R16, NR15R16, mono to perfluoro C1-4alkyl and mono to perfluoro C1-4alkoxy; R3 is C1-20 alkyl, C3-6 cycloalkyl, C3-6cycloalkylC1-5alkyl, or C1-10 alkoxyC1-10 alkyl, each of which may be unsubstituted or substituted by 1 or 2 substituents selected from hydroxy, C1-10 alkoxy, COOH or a salt thereof, COOC1-15 alkyl, CONR17R18, NR17R18, NR17COR18, or NR2, or R3 is R2; R10 is C1-4alkyl or a pharmaceutically acceptable in vivo hydrolysable ester group; R11 and R12 which may be the same or different is each selected from hydrogen, C1-12alkyl, CH2R13, CHR14CO2H or a salt thereof, or R11 and R12 together with the nitrogen to which they are attached form a 5- to 7 membered ring with or without one further heteroatom which is oxygen, nitrogen or sulphur, and which is unsubstituted or substituted by one or two substituents selected from the group consisting of hydroxy, oxo, C1-4alkyl, C1-4alkylCO, aryl, and aralkyl; R13 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH; R14 is CH2OH; R15 and R16 are independently hydrogen or C1-4 alkyl; R17 and R18 are independently hydrogen, C1-15 alkyl, C1-10 alkoxyC1-10 alkyl or arylC1-10 alkyl; W is SO2or a bond; X is O or S; and Y is a group of the formula â€”A1â€”A2â€”A3â€” in which A1 and A3 each represent a bond or a straight chain or branched alkylene group, said alkylene group(s) containing a total of 1 to 10 carbon atoms and A2 represents a bond or O, S, SO, SO2, CO, C&boxH;CH2, CONH, NHCO, CR15R16, CH&boxH;CH or Câ‰¡C, providing that when A2 is O, S, SO, SO2 or CONH, A3 contains at least two carbon atoms linking the A2 group and the CH2 group in formula (I).