Patent ID: 6168782
Filing Date: 2001-01-02
Classification: A61K,A61Q,C08L

Abstract:
A composition comprising an elastomeric silicone polyether prepared by a method comprising combining and reacting: (A) an .tbd.Si--H containing polysiloxane of the formula R.sub.3 SiO(R'.sub.2 SiO).sub.a (R""HSiO).sub.b SiR.sub.3, the formula (R'.sub.2 SiO).sub.a' (R""HSiO).sub.b', the formula HR.sub.2 SiO(R'.sub.2 SiO).sub.c SiR.sub.2 H, or the formula HR.sub.2 SiO(R'.sub.2 SiO).sub.a (R""HSiO).sub.b SiR.sub.2 H, where R, R', and R"" are alkyl groups with 1-6 carbon atoms, a is 0-250, a' is 0-7, b is 1-250, b' is 3-10, and c is 0-250; (B) a mono-alkenyl polyether of the formula CH.sub.2.dbd.CH(CH.sub.2).sub.f O(CH.sub.2 CH.sub.2 O).sub.g (CH.sub.2 CH.sub.3 CHO).sub.h T, or the formula CH.sub.2.dbd.CH--Q--O(CH.sub.2 CH.sub.2 O).sub.g (CH.sub.2 CH.sub.3 CHO).sub.h T, where T is hydrogen, a C.sub.1 -C.sub.10 alkyl group, an aryl group, or a C.sub.1 -C.sub.20 acyl group; Q is a divalent linking group containing unsaturation; f is 0-6, g is 4-100; and h is zero or 1-100; (C) an active ingredient capable of furnishing pharmacological activity or other direct effect in diagnosis, cure, mitigation, treatment, or prevention of disease, or which affects structures or functions of the body of man or other animal, including components that undergo chemical change in the manufacture of drug products or are present in drug products in a modified form intended to furnish specified activities or effects; (D) an .alpha.,.omega.-unsaturated hydrocarbon selected from the group consisting of .alpha.,.omega.-dienes of the formula CH.sub.2.dbd.CH(CH.sub.2).sub.d CH.dbd.CH.sub.2, .alpha.,.omega.-diynes of the formula CH.tbd.C(CH.sub.2).sub.e C.tbd.CH, and .alpha.,.omega.-ene-ynes of the formula CH.sub.2.dbd.CH(CH.sub.2).sub.e C.tbd.CH, where d is 0-20 and e is 0-20; and (E) a platinum catalyst; in the presence of (F) an oil selected from the group consisting of (i) organic compounds, (ii) compounds containing a silicon atom, (iii) mixtures of organic compounds, (iv) mixtures of compounds containing a silicon atom, and (v) mixtures of organic compounds and compounds containing a silicon atom; and allowing the reaction to continue until there is formed a crosslinked three-dimensional gelled network of an elastomeric silicone polyether containing the active ingredient and the oil.