Patent ID: 7795205
Filing Date: 2010-09-14
Classification: A61K,A61P

Abstract:
1. A method of effecting regression of tumor mass and size in a metastasized pancreatic tumor in a subject, the method comprising administering to the subject a pharmaceutical formulation comprising an effective amount of a desulphatohirudin variant selected from the group consisting of a) SEQ ID NO:1 wherein Xaa at 27, 36 and 47 are each Lys, Xaa at 51 is His and Xaa at 62-65 is the peptide residue Glu-Tyr-Leu-Gln (SEQ ID NO:2) Xaa at 66 not present, b) SEQ ID NO:1 wherein Xaa at 27 is Ile or Glu and Xaa at 36, 47, 51 and 62-66 are as defined in a), c) SEQ ID NO:1 wherein Xaa at 36 is Ile or Glu and Xaa at 27, 47, 51 and 62-66 are as defined in a), d) SEQ ID NO:1 wherein Xaa at 47 is Ile or Glu and Xaa at 27, 36, 51 and 62-66 are as defined in a), and e) SEQ ID NO:1 wherein Xaa at 51 is Leu or Asp and Xaa at 27, 36, 47 and 62-66 are as defined in a), to effect regression of the metastasized pancreatic tumor in the subject.