Patent ID: 8927512
Filing Date: 2015-01-06
Classification: A61K,C12N,C12Q

Abstract:
1. A method for preventing or inhibiting cancer metastasis, the method comprising administering an RNA aptamer to a patient in need of inhibition of metastasis, wherein the RNA aptamer is 35 to 49 bases in length and binds to a linkage region between N domain and A1 domain of carcinoembryonic antigen (CEA), and the RNA aptamer comprises continuous 35 or more bases comprising the nucleotide sequence from 9 <SEQ ID NO: 13> GCGGAAGCGUGCUGGGCUAGAAUAAUAAUAAGAAAACCAGUACUUUCGU; and wherein C_(cytosine) and U_(uracil) in the RNA aptamer is modified by substituting 2′ hydroxyl group with fluoro group.