Patent ID: 8519051
Filing Date: 2013-08-27
Classification: A61K,A61P,C08G,C08L

Abstract:
1. A drug conjugated block copolymer in which a drug having a ketone structure being bound to a hydrazide group of the block copolymer, said block copolymer comprising a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain, wherein the block copolymer comprises the following structure: wherein R R R L m represents an integer of 5-1000, n represents an integer of 0-1000, p represents an integer of 1-1000, and q represents an integer of 1-1000, provided that when units having a hydrophobic group in the side chain account for 25% or more 75% or less of the total units of the polyamino acids in the block copolymer and when units having a carboxylic acid group in the side chain are present, then the units having a carboxylic acid group in the side chain, units having a hydrophobic group in the side chain, and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and when units having a carboxylic acid group in the side chain are absent, then the units having a hydrophobic group in the side chain and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and y represents an integer of 1 or 2, and wherein as a result of said drug being bound to said block copolymer, the units having a hydrazide group in the side chain account for more than 0% to 35% or less of the total units of the polyamino acids in the block copolymer.