Patent ID: 6703382
Filing Date: 2004-03-09
Classification: A61K,A61P

Abstract:
A method for promoting apoptosis in cells overexpressing Bcl-2 in a subject comprising administering to said subject a therapeutically effective amount of a compound of the general formila: wherein X and Y are each independently hydrogen, OR or OR1; wherein R and R1 are each independently hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C8) cycloalkyl, phenyl or trifluoromethyl; wherein R2, R3, R4 and R5 are each independently hydrogen, hydroxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C8) cycloalkyl, phenyl, (C1-C6) alkoxy, trifluoromethyl, amino, (C1-C6) monoalkylamino, or (C1-C6) dialkylainino; A and Al are each independently 1 to 3 substituents selected from the group consisting of hydrogen, (C1-C6) alkyl, (C1-C6) alkenyl, fluorine, chlorine, bromine, iodine, (C1-C6) alkyl-alkoxy, amino, (C1-C6) alkylarnino and (C1-C6) dialkylamino; and pharmaceutically acceptable salts thereof.