Patent ID: 7879795
Filing Date: 2011-02-01
Classification: A61K,A61P

Abstract:
1. A method of increasing susceptibility of a bacterium to tigecycline, comprising contacting the bacterium with an efflux pump inhibitor, wherein the efflux pump inhibitor is a compound having the structure of Formula (III) or a pharmaceutically acceptable salt thereof: wherein: R X m n R R X m n R R Ar is an optionally substituted phenyl, and each optionally substituted with methyl, ethyl, n-propyl, isopropyl, cyclopropyl, tert-butyl, hydroxyl, methoxyl, ethoxyl, hydroxymethyl, trifluoromethyl, trifluoromethoxyl, or halogen moieties, and wherein: each A each B R R m n p any amino groups present in R