Patent ID: 6495677
Filing Date: 2002-12-17
Classification: A61K,A61P,C07H

Abstract:
A nucleoside analog compound of Formula 1, in which the sugar is either in L- or D-configuration: wherein Z is O, CH2, or S;R is independently H, hydroxyl, protected hydroxyl or halogen; R1, R2, R3, R4, R5, are independently selected from H, halogen, CN, CH2OH, lower alkyl, vinyl, and acetylene radical; with the proviso that when R2 is hydroxyl, then, R that is attached to the same carbon as that of R2 is not halogen; when R3 is hydroxyl, then, R that is attached to the same carbon as that of R3 is not halogen; R6 is selected from H, hydroxyl, protected hydroxyl, â€”CH2OH, â€”CH2PO(OH)2â€”, O-amino acid radical, O-retinoic acid, O-cholesterol, O-cholic acid, O-coumarinic acid, O-salicylic acid, O-succinic acid, O-bile acid radical, Oâ€”P(O)â€”(Oâ€”CH2â€”CH2â€”Sâ€”COâ€”CH3)2; O-steroid radical; O-monophosphate derivative radical, O-diphosphate derivative radical, and O-triphosphate derivative radical; R7 is selected from H, alkyl, CH3COOâ€”, CH3COO-phenyl-CH2â€”Oâ€”COâ€”, phenyl, â€”(CH2)nâ€”COOH, coumarinic acid, salicylic acid, dithiosuccinoyl derivative radical, reductase mediated cleavable group, phosphonoformic acid radical, and phosphoramidate group radical; R8 is selected from H, H*HCl, H*HBr, lower alkyl, phenyl, CH3COOâ€”, CH3COO-Phenyl-CH2â€”Oâ€”COâ€”, and phenyl; with the proviso that R7 and R8 are not H at the same time.