Patent ID: 6794364
Filing Date: 2004-09-21
Classification: A61K,A61P,C08B,C08L

Abstract:
A composition comprising a copolymer and a peptide which said copolymer is an N-acylated derivative of poly(2-amino-2-deoxy-D-glucose) in which between 1 and 50 percent of the free amines of said poly(2-amino-2-deoxy-D-glucose) are acylated with a first acyl group, said first acyl group is COE1 where E1 is selected from the group consisting of C3-33 carboxyalkyl, C3-33 carboxyalkenyl, C7-39 carboxyarylalkyl, and C9-39 carboxyarylalkenyl, and between 50 and 99 percent of the free amines of said poly(2-amino-2-deoxy-D-glucose) are acylated with a second acyl group, said second acyl group is COE2 where E2 is selected from the group consisting of C1-30 alkyl, C2-30 alkenyl, C6-37 arylalkyl, and C8-37 arylalkenyl, provided at least one of the free amines of said poly(2-amino-2-deoxy-D-glucose) is acylated with said first acyl group and wherein said peptide is H-&bgr;-D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 or a pharmaceutically acceptable salt thereof, present in said composition is ionically bound to said copolymer, wherein said first acyl group is succinyl and said second acyl group is acetyl.