Patent ID: 8183039
Filing Date: 2012-05-22
Classification: C07K,Y10S

Abstract:
1. A method for isolating or enriching for dendritic cells from a mixture of human cells: a) obtaining a mixture of human cells; b) contacting cells in the mixture with an antibody that binds BDCA-4, or antigen-binding fragment thereof, under conditions in which the antibody or antigen-binding fragment labels BDCA-4+ dendritic cells; and c) separating dendritic cells bound by the antibody or antigen-binding fragment from other cells in the mixture: wherein the mixture of human cells is obtained from bone marrow, peripheral blood, cell culture, umbilical cord blood, tonsil, lymph node, nasal membrane, spleen, skin, airway epithelia, lung, liver, gut, thymus,or Peyers patches.