Patent ID: 9107910
Filing Date: 2015-08-18
Classification: A61K,A61P,C12N,G01N

Abstract:
1. An isolated human progenitor or stem cell originated from human adult liver characterized in that: (a) the isolated human progenitor or stem cell expresses at least the mesenchymal markers vimentin and α-smooth muscle actin (ASMA), (b) the isolated human progenitor or stem cell expresses the hepatocyte marker albumin (ALB), (c) the isolated human progenitor or stem cell is negative for cytokeratin-19 (CK-19), and (d) the isolated human progenitor or stem cell has mesenchymal-like morphology; wherein said cell is further genetically modified by introduction of a nucleic acid that encodes gene products which enhance the replicative capacity, growth, differentiation and/or functioning of said cell.