Patent ID: 6448269
Filing Date: 2002-09-10
Classification: C07C,C07D

Abstract:
A bicyclic compound having a nucleus formed from two fused six-membered rings, A and B, represented by the formula (I), or a pharmaceutically acceptable salt, solvate or prodrug derivative thereof: the bicyclic nucleus of rings A and B is formula (17) below: R3 is an acidic group comprising a carboxylic acid radical; n is a number from 0 to 5; R0 is the same or different and is independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, amino, substituted amino, halo, and &boxH;O; the linking group â€”(L)â€” is selected from a group of from 1 to 4 chain atoms having the general formulae: where Z1, Z2, Z3, and Z4 are atoms independently selected from the group consisting of carbon, substituted carbon, nitrogen, substituted nitrogen, and oxygen; and Q is a basic group selected from the group consisting of piperidyl, amidinophenyl, amidophenyl, guanidinophenyl, and groups of the formula: â€ƒwherein X is a halogen.