Patent ID: 6762307
Filing Date: 2004-07-13
Classification: C07C,C07D,Y02P

Abstract:
A method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising reaction of a compound of formula witha) a diene having the formula wherein X is O, S, SO2, â€”N&boxH;Nâ€”, â€”COâ€”Oâ€”, or â€”Oâ€”COâ€”; followed by oxidation to form citalopram; or withb) a compound of formula wherein R is alkyl or optionally substituted aryl or arylalkyl, followed by conversion of the resulting compound of formula wherein R is as defined above, to a compound of formula which is converted to a compound of formula followed by oxidation of the compound of formula VII to form citalopram;and thereafter optionally converting the free base or an acid addition salt of citalopram, thus obtained, to a pharmaceutically acceptable salt thereof.