Patent ID: 6110934
Filing Date: 2000-08-29
Classification: A61K,C07D

Abstract:
A compound of formula (I) or pharmaceutically acceptable salt thereof: ##STR17## where n and p are independently integers from 1 to 4 and (n+p) is from 2 to 5;R.sup.1 is C.sub.1-6 alkylO-;R.sup.2 is hydrogen, halogen, CN, N.sub.3, trifluoromethyldiazirinyl, CF.sub.3, CF.sub.3 O--, CF.sub.3 S--, CF.sub.3 CO--, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylO-, C.sub.1-6 alkylCO-, C.sub.3-6 cycloalkylCO-, C.sub.3-6 cycloalkyl-C.sub.1-4 alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylS-, C.sub.1-6 alkylSO.sub.2 --, (C.sub.1-4 alkyl).sub.2 NSO.sub.2 -- or (C.sub.1-4 alkyl)NHSO.sub.2 --;R.sup.3 is hydrogen, halogen, NO.sub.2, CN, N.sub.3, trifluoromethyldiazirinyl, C.sub.1-6 alkylO-, C.sub.1-6 alkylS-, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl-, C.sub.1-6 alkenyl, C.sub.1-6 alkynyl, CF.sub.3 CO--, C.sub.1-6 alkylCO-, C.sub.3-6 cycloalkylCO-, C.sub.3-6 cycloalkyl-C.sub.1-4 alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C.sub.1-4 alkyl-, or --NR.sup.5 R.sup.6 were R.sup.5 is hydrogen or C.sub.1-4 alkyl, andR.sup.6 is hydrogen, C.sub.1-4 alkyl, --CHO, --CO.sub.2 C.sub.1-4 alkyl or --COC.sub.1-4 alkyl; R.sup.4 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkenyl, or C.sub.1-6 alkynyl; but excluding the compound 2,4,5-trimethoxy-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide.