Patent ID: 6538009
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
A compound of the formula wherein the dashed lines represent optional double bonds; n is one; p is an integer from one to two; X is >CR7 or â€”Nâ€”; Y is >CR8 or â€”Nâ€”; Z is >CHR9: W is >CR5R6; R1 is â€”CF3 or â€”CHF2; R2 is (C1-C6)alkyl: R3 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)alkenyl, (C1-C6)alkynyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkylcarbonyl, formyl, formamidyl, cyano, (C1-C6)alkoxycarbonyl, aminocarbonyl, N-(C1-C6)alkylaminocarbonyl or N,N-[(C1-C6)alkyl]2aminocarbonyl; wherein said R3 (C1-C6)alkyl may optionally be substituted with one to three substituents independently selected from halo, (C1-C6)alkoxy, cyano, (C1-C6)alkoxycarbonyl, aminocarbonycl, N-(C1-C6)alkylaminocarbonyl and N,N-[(C1-C6)alkyl]2aminocarbonyl; R4 is hydrogen; halo; hydroxy; (C1-C6)alkyl; or (C1-C6)alkoxy optionally substituted with one to three halogen atoms; wherein said R4 (C1-C6)alkyl group may optionally be substituted with one to three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy and cyano; R5 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl or aminocarbonyl; wherein said R5 (C1-C6)alkyl group may optionally be substituted with one to three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy and cyano; R6 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylcarbonyl, (C1-C6)alkoxycarbonyl or aminocarbonyl; R7 is hydrogen; halo; hydroxy, (C1-C6)alkyl or (C1-C6)alkoxy optionally substituted with one to three halogen atoms; wherein said R7 (C1-C6)alkyl group may optionally be substituted with one three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy and cyano; R8 is hydrogen; halo; hydroxy; (C1-C6)alkyl or (C1-C6)alkoxy optionally substituted with one to three halogen atoms; wherein said R8 (C1-C6)alkyl group may optionally be substituted with one to three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy and cyano; R9 is hydrogen; halo; hydroxy; (C1-C6)alkyl or (C1-C8)alkoxy optionally substituted with one to three halogen atoms; wherein said R9 (C1-C6)alkyl group may optionally be substituted with one to three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy or cyano; R10 is hydrogen, (C1-C6)alkyl, (C1-C6)alkylcarbonyl or aminocarbonyl; wherein said R10 (C1-C6)alkyl group may optionally be substituted with one to three substituents independently selected from halo, hydroxy, (C1-C6)alkoxy and cyano; with the proviso that either 1) X is CR7 and Y is â€”Nâ€” or 2) X is â€”Nâ€” and Y is CR8, or a pharmaceutically acceptable salt of such a compound.