Patent ID: 9212226
Filing Date: 2015-12-15
Classification: A61K,A61P,C07K

Abstract:
1. Polypeptide that comprises at least one Nanobody that specifically binds human CXCR4 (SEQ ID NO: 254) and optionally at least one Nanobody that specifically binds to a serum protein, wherein the at least one Nanobody that specifically binds human CXCR4 essentially consists of 4 framework regions (FR1 to FR4, respectively) and 3 complementarity determining regions (CDR1 to CDR3, respectively), in which CDR1 is: the amino acid sequence of SEQ ID NO: 142; and CDR2 is the amino acid sequence of SEQ ID NO: 174; and CDR3 is the amino acid sequence of SEQ ID NO: 206; in which CDR1 is the amino acid sequence of SEQ ID NO: 143; and CDR2 is the amino acid sequence of SEQ ID NO: 175; and CDR3 is the amino acid sequence of SEQ ID NO: 207.