Patent ID: 7851649
Filing Date: 2010-12-14
Classification: C01B,C07C

Abstract:
1. A process for the synthesis of a NO-releasing non steroidal anti-inflammatory drug selected from the group consisting of NO-acetylsalicylic acid, NO-diclofenac, NO-naproxen, NO-ketoprofen and NO-ibuprofen, comprising nitrating a compound of formula (II) wherein A is C 2 -C 6 alkylene chain, with nitric acid having a concentration ranging from 83 to 85%, and a concentration of nitrous acid and nitrogen oxides lower than 10 p.p.m., in a weight ratio of from 10:1 to 15:1 by weight respect to compound (II) for a time ranging from 10 to 30 minutes, to make a compound of formula (I) wherein A is as defined above, employing said compound of formula I as an intermediate in the synthesis of a NO-releasing non steroidal anti-inflammatory drug and isolating the NO-releasing non-steroidal anti-inflammatory drug.