Patent ID: 6569855
Filing Date: 2003-05-27
Classification: A61P,C07D

Abstract:
A compound having a structure according to Formula (I) whereinA is alkyl, heteroalkyl, aryl or heteroaryl, substituted or unsubstituted; R1 is NHOR2, where R2 is hydrogen or alkyl; W is one or more of hydrogen; lower alkyl; or an alkylene bridge; Y is independently one or more of hydroxy, SR3, SOR4, SO2R8, alkoxy, or amino, wherein amino is of formula NR6R7, wherein R6 and R7 are independently chosen from hydrogen, alkyl, heteroalkyl, heteroaryl, aryl, OR3, SO2R8, COR9, CSR10, and PO(R11)2; or R6 and R7 may join together to form a ring; and R3 is hydrogen, alkyl, aryl, or heteroaryl; R4 is alkyl, aryl, or heteroaryl; each R8 is independently alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino, or alkylarylamino; R9 is hydrogen, alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, or alkylarylamino; R10 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino, or alkylarylamino; R11 is alkyl, aryl, heteroaryl, or heteroalkyl; Z is hydrogen; hydroxy; alkyl; or an alkylene, or heteroalkylene; n is 1; or an optical isomer, diastereomer or enantiomer of Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.