Patent ID: 6429316
Filing Date: 2002-08-06
Classification: C07D

Abstract:
A process for preparing a pyrrolidone derivative, which comprises allowing at least one of &ggr;-butyrolactone, 4-hydroxybutyric acid, and a low-molecular weight polymer of 4-hydroxybutyric acid to react with an alkylamine, wherein (i) said alkylamine has a content of primary amine of from 20% to 85% by weight, and (ii) a molar ratio of total primary and secondary amines charged to total &ggr;-butyrolactone, 4-hydroxybutyric acid, and low-molecular weight polymer of 4-hydroxybutyric acid charged satisfies formula:1.0&lE;(A1+A2/2.5)/(B1+B2+B3) wherein A1, A2, B1, B2, and B3 represent the molar amounts of a primary amine, a secondary amine, &ggr;-butyrolactone, 4-hydroxybutyric acid, and a low-molecular weight polymer of 4-hydroxybutyric acid, respectively.