Patent ID: 6417192
Filing Date: 2002-07-09
Classification: A61P,C07D

Abstract:
A compounds of formula (I): in which:Z is CR3R4, where R3 and R4 are each hydrogen or C(1-4)alkyl, or R3 and R4 together with the intervening carbon atom form a C(3-6)cycloalkyl ring; and R1 is an aryl or heteroaryl group, substituted or substituted by 1, 2, 3 or 4 substituents selected from the group consisting of C(1-18)alkyl, C(1-18)alkoxy, C(1-18)alkylthio, arylC(1-18)alkoxy, oxo, hydroxy, halogen, CN, COR5, COOR5, CONR5R6, NR5COR6, SO2NR5R6, NR5SO2R6, NR5R6, mono to perfluoro-C(1-4)alkyl and mono to perfluoro-C(1-4)alkoxy; X is O or S; Y is â€”A1â€”A2â€”A3â€” in which A1 and A3 each represent a bond or a straight chain or branched C(1-10)alkylene group and A2 represents a bond or O, S, SO, SO2, CO, C&boxH;CH2, CH&boxH;CH , Câ€¢C, CONH, NHCO, or CR5R6, providing that when A2 is O, S, SO, SO2 or CONH, A3 contains at least two carbon atoms linking the A2 group and the CH2 group in formula (I); R2 is an aryl or heteroaryl group, unsubstituted or substituted by 1, 2, 3 or 4 substituents selected from the substituents hereinbefore defined for R1, as well as aryl and arylC(1-4)alkyl; W is SO2 or a bond; and R7 is R1 or a hydrocarbyl group which hydrocarbyl group may be optionally interrupted within the carbon chain by a group selected from the group consisting of O, COO, OCO, CO, CONR8, NR8CO, NR8CONR9, NR8COO, OCONR8, and NR8, and which hydrocarbyl group may also be optionally substituted by 1 or 2 substituents selected from the group consisting of mono to perfluoro-C(1-4)alkyl, OR8, COOR8, CONR8R9, NR8COR9, NR8CONR9R10, NR8COOR9, OCONR8R9, NR11R12 and R1; R5 and R6 are independently hydrogen or C(1-20)alkyl; for instance C(1-4)alkyl (e.g. methyl or ethyl); R8, R9 and R10 are independently selected from the group consisting of hydrogen, C(1-20)alkyl which may be fluorinated, including up to perfluorinated on the terminal 1 to 3 carbon atoms), C(1-20)alkenyl (preferably C(12-18)alkenyl, aryl, arylC(1-10)alkyl, C(1-10)alkoxyC(1-10)alkyl, or aryloxyC(1-10)alkyl and in which an aryl group may have one or two substituents selected from the group consisting of halogen, C(1-20)alkyl, C(1-20)alkoxy, aryloxy and COOC(1-20)alkyl; and R11 and R12 are independently selected from one of the values hereinbefore defined for R8 and R9 or R11 and R12 together with the nitrogen atom to which they are attached form a 5- to 7 membered ring optionally containing one or two further heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, and optionally substituted by one or two substituents which is hydroxy, oxo, C(1-4)alkyl, phenyl, or benzyl.