Patent ID: 9078928
Filing Date: 2015-07-14
Classification: A61K,A61P,C07K

Abstract:
1. A conjugated molecule comprising a peptide derived from the CD4 receptor, said peptide being coupled to an organic molecule by means of a linker, wherein: the said peptide derived from the CD4 receptor comprises the following general sequence (I): in which: P1 represents 3 to 6 amino acid residues, P2 represents 2 to 4 amino acid residues, P3 represents 6 to 10 amino acid residues, Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa the amino acid residues in P1, P2 and P3 being natural or non-natural, identical or different, said residues of P1, P2 and P3 being all different from the Lys residue and P1, P2 and P3 having a sequence in common or not, and the said organic molecule comprises the said anionic polypeptide being linked to the linker by the said molecular group of formula A-Z, the linker resulting from the coupling of a bifunctional compound respectively with the peptide derived from the CD4 receptor and the organic molecule, the said bifunctional compound incorporating two active groups wherein one of the two active groups is capable of forming a covalent bond with the free amino group (—NH 2 ) of the residue of the amino acid Lys present in general sequence (I) and the other active group is a halogen atom or a maleimide group when Z is a thiol or a protective thiol group when Z is a halogen atom or a maleimide group.