Patent ID: 6287829
Filing Date: 2001-09-11
Classification: C12P,Y10S

Abstract:
Process for preparing compounds of the formula ##STR5##where in the formula II one of the radicals X, Y is hydrogen,n is one of the integers 0, 1, 2 or 3, where the compounds of the formula I may contain a double bond in the ring, andm is one of the numbers 0 or 1,Z.sub.1 and Z.sub.2 independently of one another are a C.sub.1 - to C.sub.8 -alkylene radical, which may optionally be substituted by C.sub.1 - to C.sub.4 -alkyl and/or be an alkenylene radical,R.sub.1, R.sub.2 independently of one another are hydrogen or unbranched or branched or cyclic C.sub.1-4 -alkyl or R.sub.1 and R.sub.2 together with the ring containing the group A form a bicyclic compound of the structure bicycloheptane to decane (a, b, c=0, 1, 2, 3 or 4),which may optionally be substituted by C.sub.1 -C.sub.4 -alkyl and/or alkene, andR.sub.3, R.sub.4 may be hydrogen or an unbranched, branched or cyclic C.sub.1 -C.sub.8 -alkyl, which comprises reacting a compound of the formula ##STR6##where A, A', R.sub.1, R.sub.2, R.sub.3, R.sub.4, Z.sub.1, Z.sub.2, m and n have the above meaning, being protected with a chiral, aliphatic, cyclic or heterocyclic diol, amino alcohol, acetyl, aminoacetal, mercaptol or aminal as anchor/protecting group,the compound protected in this manner being enzymatically regioselectively and stereoselectively hydroxylated,the hydroxyl group being optionally protected with a protecting group and the anchor/protecting group being removed.