Patent ID: 6545030
Filing Date: 2003-04-08
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I): W is one of the following formulae: X is NH; X2 is OH, SH, or NHRE; each of RE and RF is H or C1-4 alkyl; each of R1 and R2 is independently selected from H, F, NO2, Br and Cl; R1 can also be SO2NRGRH, or R1 and R2 together with the benzene ring to which they are attached constitute an indole, isoindole, benzofuran, benzothiophene, indazole, benzimidazole, or benzthioazole; R3 is H or F; each of RG, RH, and R4 is independently selected from H, Cl and CH3; and wherein each hydrocarbon radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, hydroxyl, amino, (amino)sulfonyl, and NO2; and wherein each heterocyclic radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, C3-4 alkyl, C3-6 cycloalkyl, C3-4 alkenyl, C3-4 alkynyl, phenyl, hydroxyl, amino, (amino)sulfonyl, and NO2, wherein each substituent alkyl, cycloalkyl, alkenyl, alkynyl or phenyl is in turn optionally substituted with between 1 and 2 substituents independently selected from halo, C1-2 alkyl, hydroxyl, amino, and NO2; or a pharmaceutically acceptable salt or C1-8 ester thereof.