Patent ID: 6375986
Filing Date: 2002-04-23
Classification: A61K,Y10S

Abstract:
A solid dose nanoparticulate composition comprising:(a) an active agent which has a solubility in a liquid dispersion medium of less than about 10 mg/mL; (b) at least one polymeric surface stabilizer adsorbed on the surface of the active agent; and (c) about 0.1% to about 20% w/w, of dioctyl sodium sulfosuccinate (DOSS), wherein the effective average particle size of the nanoparticulate dispersion prior to incorporation in the solid dose formulation, comprising said poorly soluble active agent and at least one polymeric surface stabilizer, is less than about 1 micron, and upon reconstitution in media representative of human physiological conditions, the solid dose nanoparticulate composition redisperses such that 90% of the active agent particles have a particle size of less than about 5 microns.