Patent ID: 6159952
Filing Date: 2000-12-12
Classification: A61K,A61P

Abstract:
A method of increasing mucociliary clearance and/or cough clearance in a subject in need of such treatment, said method comprising:administering to the subject a compound of Formula II or IV; or a pharmaceutically acceptable salt thereof, in a pharmaceutical carrier having an amount of said compound effective to mucociliary clearance and/or cough clearance: ##STR5## wherein: B is uracil or adenine attached as in Formula III;wherein: ##STR6## wherein: R.sub.1 is selected from the group consisting of O, imido, methylene and dihalomethylene, X.sub.1, X.sub.2 and X.sub.3 are each independently selected from the group consisting of OH and SH,R.sub.5 and R.sub.6 are H while R.sub.7 is nothing and there is a double bond between N-3 and C-4 (cytosine), orR.sub.5, R.sub.6 and R.sub.7 taken together are --CH.dbd.CH--, forming a ring from N-3 to N-4 with a double bond between N-4 and C-4 (3,N4-ethenocytosine).