Patent ID: 8629108
Filing Date: 2014-01-14
Classification: A61K,A61P,C12N

Abstract:
1. A method of treating a patient with rheumatoid arthritis comprising (i) activating synovial T cells in the presence of peripheral blood mononuclear cells and IL-2, wherein the synovial T cells and peripheral blood mononuclear cells are obtained from a patient with rheumatoid arthritis, and wherein the peripheral blood mononuclear cells are attenuated with irradiation or chemical treatment to be replication incompetent yet viable; (ii) expanding the activated T cells of (i) in the presence of a T cell mitogen and IL2, wherein the expanded cells are characterized by the following: (iii) attenuating the expanded T cells of (ii) with irradiation or chemical treatment to make the T cells replication incompetent yet viable; and (iv) co-administering the attenuated T cells of (iii) with an IL2 receptor a-chain peptide corresponding to residues 61-73 or residues 145-167 of the IL2 receptor α-chain to the patient with rheumatoid arthritis, thereby treating rheumatoid arthritis in the patient.