Patent ID: 9068166
Filing Date: 2015-06-30
Classification: A61K,A61P,C07C,C07D,C12N

Abstract:
1. A method of inducing differentiation of mesenchymal stem cells to chondrocytes, comprising: incubating the mesenchymal stem cells in a medium comprising at least one compound selected from the group consisting of: 1) quinoline-8-sulfonic acid (4-hydroxy-phenyl)-amide; 2) quinoline-8-sulfonic acid (7-hydroxy-naphthalen-1-yl)-amide; 3) 2-hydroxy-5-(quinoline-8-sulfonylamino)-benzoic acid; 4) 5-(4-tert-butyl-benzenesulfonylamino)-2-hydroxy-benzoic acid; 5) biphenyl-4-sulfonic acid (5-hydroxy-naphthalen-1-yl)-amide; 6) N-(4-hydroxy-naphthalen-1-yl)-4-methyl-benzenesulfonamide; 7) naphthalene-2-sulfonic acid (4-hydroxyl-phenyl)-amide; 8) N-(5-hydroxyl-naphthalen-1-yl)-4-methyl-benzenesulfonamide; 9) N-(7-hydroxyl-naphthalen-1-yl)-4-methyl-benzenesulfonamide; 10) 4-tert-butyl-N-(3-hydroxyl-phenyl)-benzenesulfonamide; 11) 4-tert-butyl-N-(2-chloro-4-hydroxyl-phenyl)-benzenesulfonamide; 12) biphenyl-4-sulfonic acid (2-chloro-4-hydroxyl-phenyl)-amide; 13) naphthalene-2-sulfonic acid (2-chloro-4-hydroxyl-phenyl)-amide; 14) 4-tert-butyl-N-(2-fluoro-4-hydroxyl-phenyl)-benzenesulfonamide; 15) biphenyl-4-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide; 16) naphthalene-2-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide; 17) 4-tert-butyl-N-(3-fluoro-4-hydroxyl-phenyl)-benzenesulfonamide; 18) biphenyl-4-sulfonic acid (3-fluoro-4-hydroxyl-phenyl)-amide; 19) naphthalene-2-sulfonic acid (3-fluoro-4-hydroxyl-phenyl)-amide; 20) naphthalene-2-sulfonic acid (3-nitro-4-hydroxyl-phenyl)-amide; 21) 4-tert-butyl-N-[2-(3,4-dihydroxyl-phenyl)-ethyl]-benzenesulfonamide; 22) biphenyl-4-sulfonic acid [2-(3,4-dihydroxyl-phenyl)-ethyl]-amide; 23) naphthalene-2-sulfonic acid [2-(3,4-dihydroxyl-phenyl)-ethyl]-amide; 24) 4-tert-butyl-N-ethyl-N-(5-hydroxyl-2-methyl-phenyl)-benzenesulfonamide; 25) naphthalene-2-sulfonic acid ethyl-(5-hydroxyl-2-methyl-phenyl)-amide; 26) 4-tert-butyl-N-[4-(2-hydroxyl-ethyl)-cyclohexyl]-benzenesulfonamide; 27) biphenyl-4-sulfonic acid [4-(2-hydroxyl-ethyl)-cyclohexyl]-amide; and 28) naphthalene-2-sulfonic acid [4-(2-hydroxyl-ethyl)-cyclohexyl]-amide.