Patent ID: 8466293
Filing Date: 2013-06-18
Classification: C07D

Abstract:
1. Process for preparing a 2,2-difluoroethylamine derivative of formula (III) in which A is an optionally substituted heterocycle which is selected from the group consisting of pyrid-2-yl, pyrid-4-yl and pyrid-3-yl which is optionally 6-substituted by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy, and pyridazin-3-yl, which is optionally 6-substituted by chlorine or methyl, and pyrazin-3-yl, 2-chloropyrazin-5-yl and 1,3-thiazol-5-yl which is optionally 2-substituted by chlorine or methyl, and pyrimidinyl, pyrazolyl, thiophenyl, oxazolyl, isoxazolyl, 1,2,4-oxa-diazolyl, isothiazolyl, 1,2,4-triazolyl and 1,2,5-thiadiazolyl, which are optionally substituted by fluorine, chlorine, bromine, cyano, nitro, optionally fluorine- and/or chlorine-substituted C in which X is halogen, C Y is halogen, C in which Hal is Cl, Br or iodine with an amine of the general formula (II) optionally in the presence of a base.