Patent ID: 6071903
Filing Date: 2000-06-06
Classification: C07D

Abstract:
A compound of Formula 1: ##STR66## wherein R is selected from hydrogen, (C.sub.1 -C.sub.3)alkyl, --CN, --OR', --SR', --CF.sub.3, --OCF.sub.3, Cl, F, NH.sub.2, NH(C.sub.1 -C.sub.3)alkyl, --N(R')CO(C.sub.1 -C.sub.3)alkyl, --N(R')(R'), NO.sub.2, --CONH.sub.2, --SO.sub.2 NH.sub.2, --SO.sub.2 N(R')(R'), --N(R')COCH.sub.2 O--(C.sub.1 -C.sub.3)alkyl, wherein R' is (C.sub.1 -C.sub.3) alkyl or hydrogen;R.sub.4 is hydroxy, (C.sub.1 -C.sub.6) alkyl--O--, (C.sub.1 -C.sub.6) alkyl--S--, ##STR67## wherein R is hydrogen, halogen, cyano, methyl or --OCH.sub.3 ; R.sub.1 and R.sub.2 are each, independently, hydrogen or CH.sub.3 ;R.sub.3 is (C.sub.1 -C.sub.8)alkyl, NH.sub.2 CH.sub.2 CO--, (C.sub.1 -C.sub.6)alkylNHCH.sub.2 CO--, HO(CH.sub.2).sub.m CO--, HCO--. Aryl(CH.sub.2).sub.n CO--, Heteroaryl(CH.sub.2).sub.n CO--, (C.sub.1 -C.sub.3)alkyl--O--(CH.sub.2).sub.n CO--, (C.sub.1 -C.sub.3)alkylCO--, (C.sub.1 -C.sub.3)alkylCO--NHCH.sub.2 CO--, (C.sub.3 -C.sub.7)cycloalkylCO--, (C.sub.1 -C.sub.3)alkylSO.sub.2 --, Aryl(CH.sub.2).sub.n SO.sub.2 --, Heteroaryl(CH.sub.2).sub.n SO.sub.2 --, (C.sub.1 -C.sub.3)alkyl--O--(CH.sub.2).sub.m --SO.sub.2 --, (C.sub.1 -C.sub.3)alkyl--O--(CH.sub.2).sub.m, (C.sub.1 -C.sub.3)alkyl--O--(C.sub.1 -C.sub.3)alkyl--O--(C.sub.1 -C.sub.3)alkyl, HO--(C.sub.1 -C.sub.3)alkyl--O--(C.sub.1 -C.sub.3)alkyl, Aryl--O--CH.sub.2 CO--, Heteroaryl--O--CH.sub.2 CO--, ArylCH.dbd.CHCO--, HeteroarylCH.dbd.CHCO--, (C.sub.1 -C.sub.3)alkylCH.dbd.CHCO--, ##STR68## Aryl(C.sub.1 -C.sub.3)alkyl, Heteroaryl(C.sub.1 -C.sub.3)alkyl, ArylCH=CHCH.sub.2 --, HeteroarylCH.dbd.CHCH.sub.2 --, (C.sub.1 -C.sub.6)alkylCH.dbd.CHCH.sub.2 --, ##STR69## R'OCH.sub.2 CH(OR')CO--, (R'OCH.sub.2).sub.2 C(R')CO--, ##STR70## [(C.sub.1 -C.sub.6)alkyl].sub.2 --N--(C.sub.1 -C.sub.6)alkyl CO--, or (C.sub.1 -C.sub.6)alkyl--NH--(C.sub.1 -C.sub.6)alkylCO--;whereinm=1to 3; n 0 to 3;Aryl is ##STR71## and Heteroaryl is ##STR72## wherein X is hydrogen, halogen, (C.sub.1 -C.sub.3)alkyl or --OCH.sub.3, and R and R' are as defined above;L is hydrogen, (C.sub.1 --C.sub.3)alkyl, --CN, --OR', --SR', --CF.sub.3, --OCF.sub.3, Cl, F, NH.sub.2, --NH--(C.sub.1 -C.sub.3)alkyl, --N(R')CO(C.sub.1 -C.sub.3)alkyl, N(R')(R'), --NO.sub.2, --CONH.sub.2, --SO.sub.2 NH.sub.2 -- SO.sub.2 N(R')(R'), --N(R')COCH.sub.2 O--(C.sub.1 -C.sub.3)alkyl, ##STR73## M is ##STR74## or N(R')(R') where R' is as defined above; W is O, S, NH or N(C.sub.1 -C.sub.3)alkyl;Y is hydrogen, F, Cl, CF.sub.3 or OCH.sub.3 ; and X' is halogen, hydrogen, (C.sub.1 -C.sub.3)alkyl, O--(C.sub.1 -C.sub.3)alkyl, or --CH.sub.2 OH; and pharmaceutically acceptable salts thereof.