Patent ID: 7897793
Filing Date: 2011-03-01
Classification: C07B,C07C,C07D,C07F

Abstract:
1. A process for the preparation of a 13,14-dihydro-PGF 2α derivative of the general formula (VIII) having an R or an S optical configuration at carbon 15 wherein: R represents —COOH or —COOY; Y is a C Z represents H, a methyl or a phenyl, optionally substituted by a C R n represents an integer from 0 to 6; the process comprising the steps of: (a) generating an anion of the sulfone of formula (V) at the α position in relation to the sulfonyl group wherein (b) reacting the anion generated in step (a) with an alkylating agent of the general formula (VI), to yield a compound of the general formula (VII) wherein (c) performing a reductive desulfonation of the compound of the general formula (VII) obtained in step (b) to yield the compound of the general formula (VIIa) wherein n represents an integer from 0 to 6; and (d) removing the hydroxyl protecting groups from the compound of the general formula (VIIa) to yield the compound of formula (VIIb) wherein (e) converting the compound of formula (VIIb) obtained in step (d) to a compound of the general formula (VIII); wherein