Patent ID: 6875791
Filing Date: 2005-04-05
Classification: A61P,C07D

Abstract:
1. A compound having the Formula I-EMPS: or a pharmaceutically acceptable salt thereof, wherein; B is cyclopropyl; A is a single covalent bond; R K is C(R R E Y wherein D 5 , D 6 , J 5 , and J 6 are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2 is independently selected from the group consisting of C, and N + , no more than one of D 5 , D 6 , J 5 , and J 6 is O, no more than one of D 5 , D 6 , J 5 , and J 6 is S, one of D 5 , D 6 , J 5 , and J 6 must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6 are O an S, no more than three of D 5 , D 6 , J 5 , and J 6 are N when K 2 is N + , and no more than four of D 5 , D 6 , J 5 , and J 6 are N when K 2 is carbon with the provisos that R 16 , R 17 , R 18 , and R 19 are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen and when Y 0 is phenyl, said phenyl attaches directly to the nitrogen of E 0 ; R Q R Q