Patent ID: 7964589
Filing Date: 2011-06-21
Classification: A61K,A61P

Abstract:
1. A process for preparing a formulation comprising the two active principles piperacillin and tazobactam: wherein the process comprises: adding a first of the two active principles in acid form, at a temperature between −10° C. and +25° C., in a solvent to obtain a mixture; salifying the mixture by adding at least one suitable sodium salt to obtain a solution; adding the second active principle into the solution of the first active principle added in acid form; preparing a solution mixture of the active principles; sterilely filtering the solution mixture obtained, feeding the sterile filtered salified solution dropwise into at least one organic solvent at a temperature between 0° C. and 50° C. to precipitate a saline solid mixture; filtering the precipitated saline mixture obtained; and drying the filtered precipitated saline mixture under vacuum at a temperature between 20° C. and 75° C.; wherein the solvent for dissolving the active principles is at least one selected from the group consisting of water, acetone, methanol and ethanol, the at least one suitable sodium salt for salifying the mixture is at least one selected from the group consisting of sodium carbonate, sodium 2-ethyl-hexanoate, sodium acetate, sodium citrate, sodium lactate, sodium methylate, and sodium ethylate, and the at least one organic solvent into which the sterile solution is fed is at least one selected from the group consisting of isopropyl alcohol, ethyl alcohol, methyl acetate, ethyl acetate and acetone.