Patent ID: 6537964
Filing Date: 2003-03-25
Classification: C07D

Abstract:
A method of treating multiple drug resistance in a mammal in need thereof, which comprises administering to said mammal, a chemotherapeutic agent and an effective amount of a chemosensitizing reversal agent of Formula (I) wherein:n is an integer of 0, 1, or 2; R1 is hydrogen or alkoxy of 1 to 10 carbon atoms; R2 is hydrogen or alkenyl of 2 to 10 carbon atoms; R3 is hydrogen, alkyl of 1 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms, R7NH(CH2)vâ€” or m is an integer of 1 to 6; v is an integer of 1 to 4; R4, R5 and R6 are hydrogen; R7 is H or R8 is selected from alkyl of 1 to 10 carbon atoms, â€”(CH2)mCO2H, or a pharmaceutically acceptable salt thereof; said chemosensitizing reversal agent being administered in an effective amount to increase the sensitivity of the chemotherapeutic agent to the multiple drug resistant cancer.