Patent ID: 9102937
Filing Date: 2015-08-11
Classification: A61P,C07H,C12N

Abstract:
1. An oligonucleotide comprising a flexible basestacking monomer with the structure wherein: X is a backbone monomer unit that can be incorporated into the backbone of a oligonucleotide or a oligonucleotide analogue, or PNA, or PNA analogues, wherein X comprises an alkylenediol, ethyleneglycol, or 1-O-methyleneglycerol, which optionally has the alkylenediol partly comprised in a ring system, L is a linker, I C is a conjugator selected from alkyl of 1 to 12 carbons, alkenyl of 2 to 12 carbons, alkynyl of 2 to 25 carbons or diazo or combinations thereof with a length of no more than 25 carbon or nitrogen atoms, and I wherein the flexible basestacking monomer leads to high thermal stability of Hoogsteen-type triplexes and duplexes, and wherein the oligonucleotide comprising a flexible basestacking monomer comprises the structure