Patent ID: 8685647
Filing Date: 2014-04-01
Classification: C12Q

Abstract:
1. A method of detecting a predisposition of an individual to develop polycystic ovary syndrome or at least one pathology or risk factor associated with polycystic ovary syndrome (PCOS), the method comprising: providing DNA of the individual; providing a plurality of probes chosen from among SEQ ID NO. 46-77, 82-97 and 100-135, or a plurality of primers chosen from among SEQ ID NO. 136-163, 168-183 and 186-221; detecting a presence of a genotype at the site N of at least one single nucleotide polymorphism (SNP) marker of the DNA using the plurality of probes or the plurality of primers, wherein a nucleotide sequence of the at least one SNP marker is shown as: SEQ ID NO.1, wherein N is C or T; SEQ ID NO.2, wherein N is A or G; SEQ ID NO.3, wherein N is C or T; SEQ ID NO.4, wherein N is A or C; SEQ ID NO.5, wherein N is C or T; SEQ ID NO.6, wherein N is A or C; SEQ ID NO.7, wherein N is C or T; SEQ ID NO.8, wherein N is C or T; SEQ ID NO.9, wherein N is A or G; SEQ ID NO.10, wherein N is C or T; SEQ ID NO.11, wherein N is C or T; SEQ ID NO.12, wherein N is C or T; SEQ ID NO.13, wherein N is A or G; SEQ ID NO.14, wherein N is C or T; SEQ ID NO.15, wherein N is A or G; SEQ ID NO.16, wherein N is C or T; SEQ ID NO.19, wherein N is C or T; SEQ ID NO.20, wherein N is C or T; SEQ ID NO.21, wherein N is C or T; SEQ ID NO.22, wherein N is A or G; SEQ ID NO.23, wherein N is A or G; SEQ ID NO.24, wherein N is C or T; SEQ ID NO.25, wherein N is A or G; SEQ ID NO.26, wherein N is C or T; SEQ ID NO.28, wherein N is G or T; SEQ ID NO.29, wherein N is A or G; SEQ ID NO.30, wherein N is C or T; SEQ ID NO.31, wherein N is A or G; SEQ ID NO.32, wherein N is C or T; SEQ ID NO.33, wherein N is C or T; SEQ ID NO.34, wherein N is C or T; SEQ ID NO.35, wherein N is C or T; SEQ ID NO.36, wherein N is A or G; SEQ ID NO.37, wherein N is C or T; SEQ ID NO.38, wherein N is C or T; SEQ ID NO.39, wherein N is C or T; SEQ ID NO.40, wherein N is A or C; SEQ ID NO.41, wherein N is G or T; SEQ ID NO.42, wherein N is G or T; SEQ ID NO.43, wherein N is C or T; SEQ ID NO.44, wherein N is A or G; or SEQ ID NO.45, wherein N is C or T; and determining, based on the genotype of said SNP marker, that the individual has a predisposition to develop polycystic ovary syndrome or at least one pathology or risk factor associated with polycystic ovary syndrome.