Patent ID: 6392040
Filing Date: 2002-05-21
Classification: A61P,C07D

Abstract:
A compound of Formula (I): whereinR1 is heteroarylaminocarbonyl optionally substituted with one or more C1-5alkyl; R2 is selected from hydrogen, C1-5alkyl, C1-5alkoxy, phenyl optionally substituted with one or more substituents selected from the group consisting of halogen and C1-5alkyl, and phenylC1-5alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, halo and di-C1-5alkylamino; R3 is selected from hydrogen, C1-5alkylcarbonyl optionally substituted with halogen, and phenylcarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, amino, C1-5alkylamino, and di-C1-5alkylamino; R4 is selected from hydrogen, C1-5alkyl, C1-5alkylcarbonyl optionally substituted with halogen, and phenylcarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, amino, C1-5alkylamino, and di-C1-5alkylamino; n is 0-3; m is 1-5; R5 is â€ƒwherein: q is 0-3; t is 0-1; X is oxygen, CH2, sulfur, hydroxy, thiol, or NRc wherein Rc is selected from hydrogen, C1-5alkyl, morpholinoC1-5alkyl, piperidinylC1-5alkyl, N-phenylmethylpiperidinyl, and piperazinylC1-5alkyl, with the proviso that if q and t are 0, X is hydroxy, thiol, or amino, A is C1-5alkoxycarbonyl, phenylcarbonyl, or R7R8Nâ€”wherein R7 and R8 are independently selected from hydrogen, C1-5alkyl, and cycloC1-9alkyl, or R7 and R8 form a 5- or 6-membered heterocyclic ring with one or more heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur, and sulfoxides and N-oxides thereof; R6 is selected from hydrogen, halogen, C1-5alkoxy, C1-5alkylamino, and di-C1-5alkylamino; or a pharmaceutically acceptable salt thereof.