Patent ID: 6608056
Filing Date: 2003-08-19
Classification: A61K,C07D

Abstract:
A fused heteroaryl compound of formula (Ib): or a salt thereof, wherein: B is a pyridine ring; R2 and R3 are combined together with the N atom adjacent thereto to form â€”NR2R3 which is a nitrogen-containing saturated heterocyclic group which may have one or two substituents selected from the group consisting of â€”OH, &boxH;O and -a lower alkyl; R4b is â€”an aryl which has one to five substituents selected from Group A4; wherein Group A4 is selected from the group consisting of -a lower alkylene-OR, â€”CONRRâ€², â€”NRâ€”CO-Cyc1, â€”NRâ€”SO2-Cyc1, â€”OR, â€”NRRâ€², â€”O-a lower alkylene-NRRâ€² and â€”O-a lower alkylene-(a nitrogen-containing saturated ring which may have one to five substituents selected from Group A), wherein Cyc1, is â€”an aryl which may have one to five substituents selected from Group A, -a heteroaryl which may have one to five substituents selected from Group A, or -a nitrogen-containing saturated heterocyclic group which may have one to five substituents selected from Group A; wherein Group A is selected from the group consisting of -a lower alkyl, -a lower alkenyl, -a lower alkynyl, -a halogen, -a halogenated lower alkyl,-a lower alkylene â€”OR, â€”NO2, â€”CN, &boxH;O, â€”OR, â€”O-a halogenated lower alkyl, â€”O-a lower alkylene-NRRâ€², â€”O-a lower alkylene-OR, â€”O-a lower alkylene-an aryl, â€”SR, â€”SO2 lower alkyl, â€”SO-a lower alkyl, â€”COOR, â€”COO-a lower alkylene-an aryl; â€”COR, â€”CO-an aryl, -an aryl, â€”CONRRâ€², â€”SO2NRRâ€², â€”NRRâ€², â€”NRâ€³-a lower alkylene-NRRâ€², â€”NRâ€²-a lower alkylene-OR, â€”NR-a lower alkylene-an aryl, â€”NRCO-a lower alkyl, â€”NRSO2-a lower alkyl, -a cycloalkyl and -a cycloalkenyl; and wherein R, Râ€² and Râ€³, may be the same or different and are independently selected from the group consisting of H or a lower alkyl.