Patent ID: 8669365
Filing Date: 2014-03-11
Classification: A61K,A61N,A61P,C07D,C07J

Abstract:
1. A process for preparing a compound of formula 136: wherein Y is CR R each of R R wherein each W independently for each occurrence is a diradical; each q is independently 1, 2, 3, 4, 5, or 6; each of R each R said process comprising the step of: contacting a compound of formula 136a with a haloalkylzinc phosphate cyclopropanating agent; wherein R to form said compound of formula 136; wherein said haloalkylzinc phosphate cyclopropanating agent is formed by combining a phosphoric acid of formula 141a or salt thereof, a dialkylzinc, and a dihaloalkylane of formula 141b: wherein each of X and X′ is independently chloride, bromide, or iodide; each of R each of R