Patent ID: 6818648
Filing Date: 2004-11-16
Classification: A61P,C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:Q&boxH;O or S(O)n; R1 is C1-C4-alkyl, -alkenyl, -alkynyl, C1-C2 haloalkyl, halogen, NR6R7, OR8, SR8, CN; R3 is (CHR16)paryl wherein the aryl group is substituted with 1-3 R18 or (CHR16)pheteroaryl wherein the heteroaryl group is substituted with 1-3 R18; V is N; Y is CR2; Z is N; R2 is independently selected at each occurrence from the group consisting of hydrogen, halo, halomethyl, methyl cyano, nitro, NR6R7, NH(COR9), and N(GOR9); X and Xâ€² are independently selected at each occurrence from the group consisting of halogen, S(O)nR8, OR8, halomethyl, NR14R15, and CN; R5 is H, halo, C1-C6 alkyl, C2-C6 alkenyl, C1-C3 haloalkyl, C1-C6 alkoxy, (CHR16)pOR8, (CHR16)pS(O)nR8, (CHR16)pNR14R15, C3-C6 cycloalkyl, C4-C6 cycloalkenyl, or CN; R6 and R7 are independently selected at each occurrence from the group consisting of: hydrogen, C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 cycloalkylalkyl, CH(R16)(CHR16)pOR8,(CHR16)pOR8, â€”(C1-C6 alkyl)-aryl, heteroaryl, â€”(C1-C6alkyl)-heteroaryl and aryl optionally substituted with 1-3 groups selected from the following: hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, amino, NHC(&boxH;O)(C1-C6 alkyl), NH(C1-C6 alkyl) N(C1 -C6 alkyl)2, nitro CO2(C1-C6 alkyl), cyano, or S(O)zâ€”(C1-C6-alkyl), or R6 and R7 can be taken together to form â€”(CH2)qA(CH2)râ€”, optionally substituted with 0-3 R7, or, when considered with the commonly attached nitrogen, R6 and R7 can be taken together to form a heterocycle, said heterocycle being substituted on carbon with 1-3 groups consisting of: hydrogen, C1-C6 alkyl, (C1-C6)alkyl(C1-C4) alkoxy, hydroxy, or C1-C6 alkoxy; A is CH2, O, S(O)n, N(C(&boxH;O)R24), N(R19), C(H)(NR14R15), C(H)(OR20), C(H)(C(&boxH;O)R21), or N(S(O)nR21); R8 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, (CH2)tR22, C3-C10 cycloalkyl, cycloalkylalkyl, â€”(C1-C6 alkyl)-aryl, heteroaryl, â€”(C1-C6 alkyl)-heteroaryl or aryl optionally substituted with 1-3 groups selected from the following: hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, amino, NHC(&boxH;O)(C1-C6 alkyl), NH(C1-C6 alkyl) N(C1-C6 alkyl)2, nitro CO2 (C1-C6 alkyl), cyano, or S(O)z(C1-C6-alkyl); R9 is independently selected at each occurrence from hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C2-C4 alkenyl, aryl substituted with 0-3 R18, and â€”(C1-C6 alkyl)-aryl substituted with 0-3 R18; R14 and R15 are independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, (CH2)tR22, or aryl substituted with 0-3 R18; R16 is a hydrogen or C1-C4 alkyl; R17 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halo, OR23, SR23, NR23R24, (C1-C6) alkyl, or (C1-C4) alkoxy; R18 is hydrogen, C1-C4 alkyl, C1-C2 haloalkyl, C1-C4 alkoxy, C(&boxH;O)R24, NO2, halogen or cyano; R19 is C1-C6 alkyl, C3-C6 cycloalkyl, (CH2)wR22, or aryl substituted with 0-3 R18; R20 is hydrogen, C(&boxH;O)R22, C1-C4 alkyl, or C2-C4 alkenyl; R21 is hydrogen, C1-C4 alkoxy, NR23R24, hydroxyl or C1-C4 alkyl; R22 is cyano, OR24, SR24, NR23R24, or C3-C6 cycloalkyl; R23 and R24 are independently selected at each occurrence from hydrogen or C1-C4 alkyl; k is 1-4; n is independently selected at each occurrence from 0-2; p is 0-3; q is 0-3; r is 1-4; t is independently selected at each occurrence from 1-6; z=0-3; and w=1-6; wherein heteroaryl is a monosubstituted or disubstituted 5-, 6- or 10-membered mono- or bicyclic aromatic ring comprising 1 to 3 heteroatoms selected from O, N and S.