Patent ID: 8420067
Filing Date: 2013-04-16
Classification: A61K,A61P,C07K,C08G

Abstract:
1. A macromolecule comprising: (1) a dendrimer comprising: (2) a first functional moiety attached to the core moiety through the first nitrogen atom; and (3) one or more second functional moieties attached to the surface amines of the outermost layer of lysine or lysine analogue building units; wherein the second functional moiety is a pharmacokinetic modifying agent selected from the group consisting of polyfluorocarbons, fatty acids, lipids, oligo- and poly-saccharides deoxycholic acids, polyethylene glycol (PEG), polypropyleneglycol (PPG), alkyl capped forms of PEG and PPG, and polyethyloxazoline motif, and the first functional moiety is not lysine or lysine analogue, and is an agent selected from the group consisting of pharmaceutically active agents and interacting agents.