Patent ID: 6307094
Filing Date: 2001-10-23
Classification: C07C

Abstract:
A process for the preparation of a compound of formula (I) ##STR3##from a compound of formula (II) ##STR4##without a reaction solvent being present which comprises the steps of(i) reacting the compound of formula (II) with hydrogen in the presence of a catalytic amount of platinum and a catalytic amount of an acid or a base to form the compound of formula (I), and(ii) separating the compound of formula (I) from the platinum catalyst,whereinX is fluoro or chloro,R is alkyl, haloalkyl, polyhaloalkyl, alkyl substituted with NR.sup.2 R.sup.3, hydroxy or OR.sup.4, phenyl or phenyl substituted with one or more groups independently selected from halo, alkyl, hydroxy, alkoxy, haloalkoxy, polyhaloalkoxy, haloalkyl or polyhaloalkyl,R' is a hydrogen atom, alkyl, haloalkyl, polyhaloalkyl, alkyl substituted with NR.sup.2 R.sup.3, hydroxy or OR.sup.4, phenyl or phenyl substituted with one or more groups independently selected from halo, alkyl, hydroxy, alkoxy, haloalkoxy, polyhaloalkoxy, haloalkyl or polyhaloalkyl,R.sup.2 and R.sup.3 are each independently a hydrogen atom, alkyl, or together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring, andR.sup.4 is alkyl, haloalkyl or polyhaloalkyl.