Patent ID: 6350462
Filing Date: 2002-02-26
Classification: A61K

Abstract:
In a porous ceramic carrier for use in sustained release preparation to be embedded in the body of a patient for sustained release of a medicament, the improvement which comprises a porous ceramic body shaped in a capsule form with a shell of porous ceramic having an outer surface and an inner surface, said inner surface defining a cavity for retaining a medicament, said porous ceramic body having pores communicating with one another to define a medicament release path from said inner surface to said outer surface to communicate said cavity with said outer surface and permit release of medicament from said cavity, said pores decreasing in diameter from the inner surface to the outer surface of said porous ceramic body whereby the pore diameter is substantially proportional to the distance from the outer surface of the carrier; and wherein the material forming the porous ceramic body is selected from the group consisting of calcium phosphate, alumina, zirconia and mixtures thereof.