Patent ID: 6096525
Filing Date: 2000-08-01
Classification: A61L,Y10S

Abstract:
A method of preparing a bio-active coating comprising:a) providing a hydrophobic, bio-compatible polymeric substrate selected from the group consisting of expanded polytetrafluoroethylene and polyethylene terephthalate;b) providing reactive OH or NH.sub.2 functionality on a surface of said substrate, said reactive functionality being bonded to said substrate through a reactive carbon atom therein;c) reacting said reactive OH or NH.sub.2 reactive functionality of said bio-compatible polymeric substrate with a hydrophilic spacer having at least one reactive isocyanate functional group at its first and second ends by reacting said at least one reactive isocyanate functional group at said first end of said spacer with said reactive OH or NH.sub.2 functionality on said bio-compatible polymeric substrate to bond said spacer thereto; andd) reacting said at least one reactive isocyanate functional group at said second end of said spacer with a bio-active agent to bond said bio-reactive agent to said spacer.