Patent ID: 6071899
Filing Date: 2000-06-06
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR8## in which: R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen or C.sub.(1-8) alkyl;R.sup.3 is C.sub.(1-8) alkyl or C.sub.(3-8) cycloalkyl each of which may be optionally substituted by halo, hydroxy, and CO.sub.2 R in which R is hydrogen, C.sub.(1-8) alkyl, C.sub.(2-8) alkenyl or an in vivo hydrolysable ester group;X is a direct bond; a group X'(CH.sub.2)m in which X' is CO, CONR.sup.5, COO or C(O)NH--O-- in which R.sup.5 is hydrogen or C.sub.(1-6) alkyl and m is 0 or an integer from 1 to 8; or a C.sub.(1-12) alkylene chain optionally interupted by X';Y is phenyl optionally substituted by halogen, cyano, (C.sub.1-6)alkyl, (C.sub.3-7)cycloalkyl, (C.sub.1-6)alkoxy, halo(C.sub.1-6)alkyl, hydroxy, amino, mono- or di-(C.sub.1-6)alkylamino, nitro, carboxy, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkoxycarbonyl(C.sub.1-6)alkyl, (C.sub.1-6)alkylcarbonyloxy, carboxy(C.sub.1-6)alkyloxy, (C.sub.1-6)alkylcarbonyloxy, (C.sub.1-6)alkylthio, (C.sub.1-6)alkylsulphinyl, (C.sub.1-6)alkylsulphonyl, sulphamoyl, mono- and di-(C.sub.1-6)-alkylsulphamoyl, carbamoyl, mono- and di-(C.sub.1-6)alkylcarbamoyl;m is 0 an integer from 1 to 12; andn is 1 or 2.