Patent ID: 6610698
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of formula or a pharmaceutically acceptable salt thereof, whereinwherein R1 is -Z-Y, provided that (1) the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in each -Z-Y is 0-3; and (2) the combined total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R1 is 0-4; wherein each Z is a bond; each Y is independently a (1) hydrogen radical; (2) halo or nitro radical; (3) â€”C(O)â€”R20 or â€”C(NR5)â€”NR5R21 radical; (4) â€”OR21, â€”Oâ€”C(O)â€”R21, â€”Oâ€”C(O)â€”NR5R21 or â€”Oâ€”C(O)â€”NR22â€”S(O)2â€”R20 radical; (5) â€”SR21, â€”S(O)â€”R20, â€”S(O)2â€”R20, â€”S(O)2â€”NR5R21, â€”S(O)2â€”NR22â€”C(O)â€”R21, â€”S(O)2â€”NR22â€”C(O)â€”OR22 or â€”S(O)2â€”NR22â€”C(O)â€”NR5R21 radical; or (6) â€”NR5R21, â€”NR22â€”C(O)â€”R21, â€”NR22â€”C(O)â€”OR20, â€”NR22â€”C(O)â€”NR5R21, â€”NR22â€”C(NR5)â€”NR5R21, â€”NR22â€”S(O)2â€”R20 or â€”NR22â€”S(O)2â€”NR5R21 radical; wherein each R5 is independently (1) hydrogen radicals; (2) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, hydroxy, alkoxy, alkylthio, â€”SO3H or halo; or (3) aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, hydroxy, alkoxy, alkylthio, alkyl or haloalkyl; and wherein each R20 is independently (1) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, aminocarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halo or aralkoxy, aralkylthio, aralkylsulfonyl, cycloalkyl, heterocyclyl, aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, alkanoyl, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halo, alkyl or haloalkyl; (2) heterocyclyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkyl or haloalkyl; or (3) aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, alkoxycarbonyl, hydroxy, alkoxy, alkylthio, cyano, halo, azido, alkyl or haloalkyl; each R21 is independently hydrogen radical or R20; each R22 is independently (1) hydrogen radical; (2) alkyl radical optionally substituted by a radical of heterocyclyl, aryl or heteroaryl optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl; or (3) heterocyclyl, aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl; provided when Y is â€”NR22â€”C(O)â€”NH2, then R22 is other then an optionally substituted aryl radical; and R11 is an aryl radical, wherein the aryl radical is substituted by 1-2 radicals of (1) R30; (2) halo or cyano radicals; (3) â€”C(O)â€”R30, â€”C(O)â€”OR29, â€”C(O)â€”NR31R32 or â€”C(NR31)â€”NR31R32 radicals; or (4) â€”OR29, â€”SR29, â€”S(O)â€”R30, â€”S(O)2â€”R30, â€”S(O)2â€”NR31R32, â€”NR31R32 or â€”NR33â€”C(O)â€”R29 radicals; R12 is a heteroaryl radical, wherein the heteroaryl radical is optionally substituted by 1-2 radicals of (1) R30; (2) halo or cyano radicals; (3) â€”C(O)â€”R30, â€”C(O)â€”OR29, â€”C(O)â€”NR31R32 or â€”C(NR31)â€”NR31R32 radicals; or (4) â€”OR29, â€”SR29, â€”S(O)â€”R30, â€”S(O)2â€”R30, â€”S(O)2â€”NR31R32, â€”NR31R32 or â€”NR33â€”C(O)â€”R29 radicals; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals substituted on each of R11 and R12 is 0-1; wherein each R30 is independently (1) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of â€”NR31R31, â€”CO2R23, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo or aralkoxy, aralkylthio, aralkylsulfonyl, heterocyclyl, aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl; (2) heterocyclyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl; or (3) aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, halo, alkyl or haloalkyl; each R29 is independently hydrogen radical or R30; each R31 and R32 are each independently (1) hydrogen radicals; (2) alkyl radical optionally substituted by an cycloalkyl, aryl, heterocyclyl or heteroaryl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl; or (3) aryl, heteroaryl, heterocyclyl or cycloalkyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl; and wherein each R33 is independently (1) hydrogen radical; or (2) alkyl radical optionally substituted by a radical of heterocyclyl, aryl or heteroaryl optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl; and provided that (1) when R11 is phenyl and R12 is 4-pyridyl, then R1 is other than H, methyl, or amino; and (2) when R11 is 2-methylphenyl and R12 is 2-pyridyl, then R1 is other than n-propyl.