Patent ID: 6022869
Filing Date: 2000-02-08
Classification: A61P,C07D

Abstract:
A compound of the formula I: ##STR7## wherein G.sup.1 and G.sup.2 independently represent CH or N; m is 0, 1 or 2;R.sup.1 is halogeno, trifluoromethyl, trifluoromethoxy, cyano, NR.sup.5 R.sup.6, hydroxy, nitro, (1-4C)alkyl or (1-4C)alkoxy;T.sup.1 is CH or N;L.sup.1 is (1-4C)alkylene, (3-6C)cycloalkane-1,2-diyl or (1-3C)alkylene-carbonyl;R.sup.2 is hydrogen or (1-4C)alkyl and R.sup.3 is hydrogen or (1-4C)alkyl, or R.sup.2 and R.sup.3 together form a (1-4C)alkylene or methylenecarbonyl group,wherein 1 or 2 methylene groups within L.sup.1 or the ring formed when R.sup.2 and R.sup.3 are linked optionally bears 1 or 2 substituents selected from carboxy, CONR.sup.5 R.sup.6, (1-4C)alkyl, (1-4C)alkoxycarbonyl, pyrrolidin-1-ylcarbonyl, piperidinocarbonyl, morpholinocarbonyl, piperazin-1-yl, carbonyl, 4-(1-4C)alkylpiperazin-1-ylcarbonyl, hydroxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, carboxy-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, CONR.sup.5 R.sup.6 (1-4C)alkyl, pyrrolidin-1-ylcarbonyl-(1-4C)alkyl, piperidino-(1-4C)alkyl, morpholino-(1-4C)alkyl, piperazin-1-yl-(1-4C)alkyl and 4-(1-4C)alkylpiperazin-1-yl-(1-4C)alkyl, and wherein any heterocyclic group in said substituent optionally bears 1 or 2 (1-4C)alkyl substituents;R.sup.4 is CONR.sup.7 (CH.sub.2).sub.n S(O).sub.p R.sup.8, CONH(CH.sub.2).sub.q NR.sup.9 R.sup.10, or the group (1-4C)alkyl-Y.sup.1 ;wherein n represents an integer 0 to 4;p represents 0, 1 or 2;q represents an integer 2 to 4;R.sup.7 represents hydrogen;R.sup.8 represents (1-4C)alkyl, phenyl or (1-4C) alkylphenyl, or R.sup.7 and R.sup.8 together form a (1-4C)alkylene group;R.sup.9 and R.sup.10 independently represent hydrogen, (1-4C)alkyl, phenyl, (1-4C)alkylphenyl, S(O).sub.p R.sup.8, COR.sup.11 or a 5- or 6-membered monocyclic heteroaryl ring having up to 3 heteroatoms selected from nitrogen, oxygen and sulphur;R.sup.11 represents hydrogen, (1-4C)alkyl, phenyl or (1-4C)alkylphenyl;Y.sup.1 represents S(O).sub.p R.sup.8, NHS(O).sub.2 R.sup.8, NHCOR.sup.12, O(CH.sub.2).sub.r R.sup.3, pyrrolidin-1-yl, piperidino, morpholino, thiamorpholino, 1-oxothiamorpholino, 1,1-dioxothiamorpholino or piperazin-1-yl,R.sup.12 represents (1-4C)alkyl, phenyl or (1-4C)alkylphenyl;r represents an integer 1 to 4;when r represents an integer 2 to 4, R.sup.13 represents hydroxy, (1-4C)alkoxy, carboxy, (1-4C)alkoxycarbonyl, S(O).sub.p R.sup.8 or NR.sup.5 R.sup.6 ; and when r represents 1, R.sup.13 represents carboxy or (1-4C)alkoxycarbonyl;wherein any heterocyclic group within R.sup.4 optionally bears 1 or 2 substituents selected from carboxy, CONR.sup.5 R.sup.6, (1-4C)alkyl and (1-4C) alkoxycarbonyl, and any phenyl group within R.sup.4 optionally bears 1 or 2 substituents selected from halogeno, trifluoromethyl, cyano, (1-4C) alkyl and (1-4C)alkoxy;X.sup.1 is a group of the formula O, S(O).sub.p, CO, COO, CONR.sup.14 or CR.sup.15 R.sup.16 ;R.sup.5, R.sup.6, R.sup.14, R.sup.15 and R.sup.16 independently represent hydrogen or (1-4C)alkyl; andQ represents phenyl, naphthyl, phenyl-(1-4C)alkyl or a heterocyclic moiety having up to 4 heteroatoms selected from nitrogen, oxygen and sulphur, and Q optionally bears 1, 2 or 3 substituents selected from halogeno, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, NR.sup.5 R.sup.6, nitro, trifluoromethanesulphonyl, carboxy, CONR.sup.5 R.sup.6, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylS(O).sub.p, (1-4C)alkoxycarbonyl, (2-4C)alkanoyl, (2-4C)alkanoylamino, hydroxy-(1-4C)alkyl, (1-4C)alkoxy-(1-C)alkyl, carboxy-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C) alkyl, CONR.sup.5 R.sup.6 (1-4C)alkyl, phenyl, heteroaryl, phenoxy, phenylS(O).sub.p, benzyl, benzoyl, heteroaryloxy, heteroarylS(O).sub.p, wherein said heteroaryl substituent has a 5- or 6-membered monocyclic heteroaryl ring having up to 3 heteroatoms selected from nitrogen, oxygen and sulphur, and wherein said phenyl, heteroaryl, phenoxy, phenylS(O).sub.p, heteroaryloxy, heteroarylS(O).sub.p, benzyl or benzoyl substituent optionally bears 1, 2 or 3 substituents selected from halogeno, trifluoromethyl, cyano, hydroxy, NR.sup.5 R.sup.6, nitro, carboxy, CONR.sup.5 R.sup.6, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxycarbonyl and (2-4C)alkanoylamino;or a pharmaceutically-acceptable salt thereof.