Patent ID: 8178502
Filing Date: 2012-05-15
Classification: A61K,A61P,C07H,G01N

Abstract:
1. A method for treating esophogeal adenocarcinoma in a mammal comprising (i) obtaining a biological sample from the tumor or cancer; (ii) determining whether the tumor or cancer overexpresses an Akt kinase, (iii) if the tumor or cancer overexpresses Akt kinase, treating the tumor or cancer with an effective amount of a compound of the formula: wherein each R2′, R3′ and R5′ are independently hydrogen, optionally substituted phosphate or phosphonate; acyl; alkyl; amide, sulfonate ester including alkyl or arylalkyl; sulfonyl, including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents; optionally substituted arylsulfonyl; a lipid, including a phospholipid; an amino acid; a carbohydrate; a peptide; or cholesterol; or other pharmaceutically acceptable leaving group that, in vivo, provides a compound wherein R2′, R3′ or R5′ is independently H or mono-,di-or tri-phosphate; wherein R wherein R