Patent ID: 7687622
Filing Date: 2010-03-30
Classification: A61P,C07D

Abstract:
1. A method for preparing quetiapine, 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[bf][1,4]thiazepine comprising the steps of: combining 11-chlorodibenzo[bf][1,4]thiazepine (I) with about 1 to about 1.5 molar equivalents with respect to (I) of 1-(2-hydroxyethoxy)ethyl piperazine (II), a base, and phase transfer catalyst or a halide that is either an alkali metal halide or a silyihalide in a reaction solvent to obtain a reaction mixture, and heating the reaction mixture at a reaction temperature from about room temperature to reflux temperature for a reaction time.