Patent ID: 6037453
Filing Date: 2000-03-14
Classification: C07K

Abstract:
A bispecific antibody which specifically binds IgE bound to the low affinity IgE receptor (FCEL) but which does not substantially bind to IgE bound to the high affinity IgE receptor (FCEH), which further comprises:(i) an IgE binding arm having human framework (FR) residues of a recipient human antibody and donor murine complementarity determining (CDR) region residues; and(ii) in the IgE binding arm, at least one human CDR residue substituted in place of the analogous murine residue; and(iii) a Fv which is specific to a predetermined antigen other than IgE;wherein the CDR residues are selected from a CDR present in the group consisting of MAE11, MAE13 and MAE15 (SEQ ID NO:2-7) as indicated in FIG. 2.