Patent ID: 6562960
Filing Date: 2003-05-13
Classification: A61P,C07H

Abstract:
An oligonucleotide analogue having 10 to 200 natural and/or synthetic nucleoside units linked by internucleoside linkages, and a 3â€²-terminal hydroxyl group, wherein at least one of the internucleoside linkages is of formula wherethe indicated methylene group is attached to a 3â€² carbon atom of a nucleoside, the indicated oxygen atom is attached to a 5â€²-carbon atom of an adjacent nucleoside, R1 is hydrogen, a group of formula R1a, or â€”NR1bR1c wherein R1a is a C1 to C10 alkyl, C2 to C10 alkenyl, C3 to C8 cycloalkyl, C6 to C10 aryl or C7 to C13 aralkyl group or a C1 to C10 alkyl, C2 to C10 alkenyl, C3 to C8 cycloalkyl, C6 to C10 aryl or C7 to C13 aralkyl group bearing one or more terminal substituents; and R1b and R1c are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C3 to C8 cycloalkyl, C6 to C10 aryl or C7 to C13 aralkyl group; and x is oxygen or sulfur.