Patent ID: 6500815
Filing Date: 2002-12-31
Classification: A61P,C07J

Abstract:
A compound of the formula wherein X and Y form together with the carbon which carries them C&boxH;O or C&boxH;CH2 or X is selected from the group consisting of hydroxy, alkoxy of 1 to 6 carbon atoms, alkylcarbonyloxy of 2 to 6 carbon atoms and Y is hydrogen;R1 is selected from the group consisting of hydroxy, alkoxy of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms; R2 is hydrogen or halogen; Z is selected from the group consisting of hydrogen, â€”NHSO2Ra, â€”NHCORa, â€”NHCO2Ra, NHSO2NHRa and â€”NHCONHRa; G is selected from the group consisting of â€ƒ(G1) in which (H) forms with the â€”N&boxH;Câ€”NHâ€” unit the remainder of a heterocycle, (G2) which is â€ƒa heterocycle (G3), â€”NRbâ€”C(&boxH;A)â€”NHRc (G4) in which A is sulfur or oxygen or NH, and â€”NRbâ€”SO2Rc (G5), â€ƒRa, Rb and Rc are individually selected from the group consisting of hydrogen, â€”(CH2)m-Alk, â€”(CH2)m-Ar and â€”(CH2)m-Het or Rb and Rc together with the nitrogen atom to which they are linked form a heterocycle, Alk is alkyl or cycloalkyl, saturated or unsaturated, unaromatic hydrocarbon of up to 12 carbon atoms, substituted by R3 or unsubstituted, Ar is carbocyclic aryl substituted by R3 or unsubstituted and Het is aromatic or nonaromatic heterocycle substituted by R3 or unsubstituted, n is an integer from 1 to 6, m is 0, 1, 2 or 3, R3 is selected from the group consisting of a) halogen, oxo, cyano, nitro, formyl, carboxy, alkoxyoxycarbonyl of 2 to 6 carbon atoms and carboxyamide, b) alkyl, alkenyl and alkynyl of up to 6 carbon atoms, unsubstituted or substituted by at least one halogen, c) cycloalkyl of 3 to 12 carbon atoms, alkoxy and alkylthio of 1 to 6 carbon atoms, d) amino, alkylamino of 1 to 6 carbon atoms, dialkylamino of 2 to 12 carbon atoms optionally in oxidized form, aminoalkyl of 1 to 6 carbon atoms or dialkylaminoalkyl of 3 to 8 carbon atoms, dialkylaminoalkoxy of 3 to 18 carbon atoms, e) an optionally acylated hydroxy of 1 to 12 carbon atoms, an acyl of 1 to 12 carbon atoms unsubstituted or substituted by chlorine, iodine or fluorine, f) aryl, carbocyclic or heterocyclic, aralkyl or aryloxy unsubstituted or substituted by at least one substituent mentioned above, said compounds of Formula I being in all their possible isomer forms, isolated or in a mixture, or their esters and their addition salts with pharmaceutically acceptable acids and bases.