Patent ID: 6677351
Filing Date: 2004-01-13
Classification: A61P,C07D

Abstract:
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, whereinAr is pyridyl or pyridonyl or oxides thereof; R is H or â€”C1-6alkyl; R1 is H, or â€”C1-6alkyl, â€”C3-6cycloalkyl, â€”C1-6alkoxy, â€”C2-6alkenyl or â€”C3-6alkynyl, optionally substituted with 1-3 independent â€”C1-6alkyl, â€”C1-6alkoxy, OH, amino, â€”(C0-6alkyl)â€”SOnâ€”(C1-6alkyl), nitro, CN, &boxH;Nâ€”Oâ€”C1-6alkyl, â€”Oâ€”N&boxH;C1-6alkyl, or halogen substituents; R2 is H, halogen, â€”C1-6alkyl, â€”C3-6cycloalkyl, â€”C1-6alkyl(C3-6cycloalkyl)(C3-6cycloalkyl), â€”C1-6alkoxy, phenyl, amino, â€”C(O)â€”C1-6alkyl, â€”C(O)â€”Oâ€”C1-6alkyl, â€”C1-6alkyl(&boxH;Nâ€”OH), â€”C(N&boxH;NOH)C1-6alkyl, â€”C0-6alkyl(oxy)C1-6alkyl-phenyl, SOnNH(C0-6alkyl), or â€”(C0-6alkyl)â€”SOnâ€”(C1-6alkyl), wherein the phenyl is optionally substituted with halogen, â€”C1-6alkyl, â€”C1-6alkoxy, hydroxy, amino, or â€”C(O)â€”Oâ€”C1-6alkyl, and any alkyl is optionally substituted with 1-6 independent halogen or â€”OH substituents; n is 0, 1, or 2; R3 is H, OH, amine, halogen or C1-6alkyl, wherein the alkyl is optionally substituted with 1-6 independent halogen or OH; and R4, R5, R6, and R7 each independently is H, halogen, â€”C1-6alkyl, â€”C1-6alkoxy, or amine, and any alkyl is optionally substituted with 1-6 independent halogen or â€”OH substituents.