Patent ID: 7091247
Filing Date: 2006-08-15
Classification: A61P,C07C,C07D

Abstract:
1. A compound represented by the formula (I): wherein R 1 is (1) hydrogen atom; (2) C (3) C (4) C (5) C (6) C (7) C (8) C (9) di-C (10) tri-C (11) a group represented by the formula —X′″—G—(CH (12) a group represented by the formula —X″″—L—(CH X represents: (1) —(CH (2) —(CH (3) —(CH A represents (1) amino which may have 1 to 2 substituents selected from (a) C (2) 5- or 6-membered cyclic amino which may have 1 to 3 substituents selected from (a) halogen, (b) nitro, (c) cyano, (d) hydroxyl group, (e) thiol, (f) amino, (g) carboxyl, (h) optionally halogenated C (3) a heterocyclic group formed by removing one hydrogen atom from a 5- to 8-membered aromatic monocyclic heterocyclic ring or saturated or unsaturated non-aromatic monocyclic heterocyclic ring containing one nitrogen atom and one to three kinds of 1 to 4 heteroatoms selected from oxygen atom, sulfur atom and nitrogen atom or by removing one hydrogen atom from a ring wherein 2 or 3 the same or different rings selected from the above monocyclic rings have been fused (said heterocyclic group optionally having 1 to 3 substituents selected from the substituent group C), R 2 represents (1) C (2) C (3) C (4) C (5) C (6) C (7) C (8) di-C (9) tri-C (10) a group represented by the formula —X′″—G—(CH (11) a group represented by the formula —X″″—L—(CH (12) amino which may have 1 to 2 substituents selected from (a) C R 3 represents (1) C (2) C (3) C (4) C (5) C (6) C (7) C (8) di-C (9) tri-C (10) a group represented by the formula —X′″—G—(CH (11) a group represented by the formula —X″″—L—(CH rings B and C each represent a benzene ring which may further have 1 to 4 substituents selected from (1) C (2) C (3) C (4) C (5) C (6) C (7) C (8) di-C (9) tri-C (10) a heterocyclic group formed by removing one hydrogen atom from a 5- to 8-membered aromatic monocyclic heterocyclic ring or saturated or unsaturated non-aromatic monocyclic heterocyclic ring containing at least 1 of one to three kinds of heteroatoms selected from oxygen atom, sulfur atom and nitrogen atom or by removing one hydrogen atom from a ring wherein 2 or 3 of the same or different rings selected from the above monocyclic rings and 5- to 8-membered cyclic hydrocarbons have been fused (said heterocyclic group optionally having 1 to 3 substituents selected from the substituent group A); (11) a halogen atom; (12) amino which may have 1 to 2 substituents selected from (a) C (13) 5- or 6-membered cyclic amino which may have 1 to 3 substituents selected from (a) halogen, (b) nitro, (c) cyano, (d) hydroxyl group, (e) thiol, (f) amino, (g) carboxyl, (h) optionally halogenated C (14) a group represented by the formula: R (15) cyano group; (16) acyl selected from formyl, C (17) acyl groups wherein a 5- to 8-membered aromatic heterocyclic group or saturated or unsaturated non-aromatic heterocyclic group containing at least one of 1 to 3 kinds of heteroatoms selected from oxygen atom, sulfur atom and nitrogen atom has been bound to carbonyl or sulfonyl (said acyl optionally having 1 to 3 substituents selected from the substituent group C); (18) carboxyl; and (19) carbamoyl which may have 1 to 2 substituents selected from (a) C or a salt thereof, provided that (1) a compound represented by the formula: wherein each symbol is as defined above and (2) 4′-[[(methoxyacetyl)methylamino]methyl]-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2′-methyl-[1,1′-biphenyl]-4-carboxamide are excluded.