Patent ID: 7393828
Filing Date: 2008-07-01
Classification: A61K,A61P,C07C,Y02A

Abstract:
1. A protein modified with a pH-responsive or light-responsive compound of the general formula Q-C or P—C, wherein Q is a chargeable group selected from the group consisting of Q wherein R wherein P is a photocleavable chargeable group selected from the group consisting of P wherein, R wherein C is a coupling group selected from the group consisting of C wherein X═Br, I and wherein the protein is a mechanosensitive channel of large conductance (MscL), and wherein the compound is attached via coupling group C to a cysteine residue of the protein, located in a region that corresponds to amino acid residues 1-14, residues 15-45, residues 46-75 or residues 76-100 of the MscL protein of