Patent ID: 8552033
Filing Date: 2013-10-08
Classification: A61P,C07C,C07D

Abstract:
1. A compound of the formula I wherein X is —CR3=CR4-; R3 and R4, are, independently of one another, hydrogen, F, Cl, Br, I, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, cycloalkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11 hydrogen atoms may be substituted by fluorine atoms, alkoxy having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, —S-alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, OH, CN, NO R27 is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R28 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, aryl, C(O)H, C(O)alkyl with alkyl having 1, 2, 3 or 4 carbon atoms or C(O)aryl; R29 is hydrogen, OH, alkyl with 1, 2, 3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; R30, R31, R33 and R34 are, independently of one another, hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or aryl; R32 is OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; o and p are, independently of one another, 1 or 2; Y1, Y2, Y3 and Y4 are, independently of one another, —CR8- or nitrogen, with the proviso that at least two of Y1, Y2, Y3 and Y4 are defined as —CR8-; R8 is hydrogen, F, Cl, Br, I, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, cycloalkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11 hydrogen atoms may be substituted by fluorine atoms, alkoxy having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, —S -alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, in which 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 hydrogen atoms may be substituted by fluorine atoms, OH, CN, NO R36 is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms R37 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, aryl, C(O)H, C(O )alkyl with alkyl having 1, 2, 3 or 4 carbon atoms or C(O)aryl; R38 is hydrogen, OH, alkyl with 1,2,3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; R39, R40, R42 and R43 are, independently of one another, hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or aryl; R41 is OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; q and r are, independently of one another, 1 or 2; A is cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, heterocycle, aryl or heteroaryl; in which the cycloalkyl or heterocycle radical can be condensed to an aryl or heteroaryl radical and in which the cycloalkyl or heterocycle radical and the optionally condensed aryl or heteroaryl radical are unsubstituted or substituted by by 1, 2, 3 or 4 radicals selected from the group consisting of F, Cl, Br, I, OH, CN, NO R9 is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R10 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, aryl, C(O)H, C(O)alkyl having 1, 2, 3 or 4 carbon atoms or C(O)aryl; R44 is hydrogen, OH, alkyl with 1,2,3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms or aryl; R45, R46, R48 and R49 are, independently of one another, hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or aryl; R47 is OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; a is zero or 1; b, c, k and 1 are, independently of one another, zero, 1, 2 or 3; s and t are, independently of one another, 1 or 2; in which the aryl or heteroaryl radical can be condensed to an cycloalkyl or heterocycle radical and in which the aryl or heteroaryl radical and the optionally condensed cycloalkyl or heterocycle radical are unsubstituted or substituted by 1, 2, 3 or 4 radicals selected from the group consisting of F, Cl, Br, I, OH, CN, NO R9 is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms R10 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, aryl, C(O)H, C(O)alkyl having 1, 2, 3 or 4 carbon atoms or C(O)aryl; R44 is hydrogen, OH, alkyl with 1,2,3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms or aryl; R45, R46, R48 and R49 are, independently of one another, hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or aryl; R47 is OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy with 1, 2, 3 or 4 carbon atoms or aryl; A is zero or 1; b, c, k and 1 are, independently of one another, zero, 1, 2 or 3; s and t are, independently of one another, 1 or 2; B is —O—C(R11R12)-; R11 and R12 are hydrogen; R1 is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms; which can be unsubstituted or substituted by 1, 2, 3, 4 or 5 radicals selected from the group consisting of F, Cl, Br, I and —O i is 0 or 1; j is 0, 1, 2 or 3; R25 is hydrogen, phenyl, heteroaryl having 5 or 6 atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms or heterocyclyl having 3, 4, 5, 6, 7 or 8 atoms, in which the phenyl, heteroaryl, cycloalkyl or heterocyclyl are unsubstituted or substituted by 1, 2 or 3 radicals selected from the group consisting of F, Cl, Br and I, and R2 is phenyl, heteroaryl having 5 or 6 atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or heterocyclyl having 3, 4, 5, 6, 7 or 8 atoms; wherein phenyl, heteroaryl having 5 or 6 atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or heterocyclyl having 3, 4, 5, 6, 7 or 8 atoms are unsubstituted or substituted by 1, 2, 3, 4 or 5 radicals selected from the group consisting of F, Cl, Br, I, OH, CN, NO or R2 is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms which is substituted by 1, 2, 3, 4 or 5 radicals selected from the group consisting of —O m is 0 or 1; n is 0, 1, 2 or 3; R26 is cycloalkyl having 3, 4, 5 or 6 carbon atoms which is unsubstituted or substituted by 1, 2 or 3 radicals selected from the group consisting of F, Cl, Br and I; or R1 and R2 form, together with the carbon atom to which they are attached, a 5- or 6-membered partially unsaturated carbon ring containing one or two double bonds and in which the formed ring can optionally be condensed to phenyl, heteroaryl having 5 or 6 atoms, cycloalkyl having 3, 4, 5, 6,7 or 8 carbon atoms or heterocyclyl having 3, 4, 5, 6, 7 or 8 atoms, wherein the formed ring and the optionally condensed phenyl, heteroaryl, cycloalkyl or heterocyclyl radical can be unsubstituted or substituted by 1, 2, 3, 4 or 5 radicals selected from the group consisting of F, Cl, Br, I, CN, NO or R1 and R2 form, together with the carbon atom to which they are attached, a 4-, 5- or 6-membered carbon ring, wherein one carbon atom, which is not adjacent to the carbon atom to which R1 and R2 are attached, is replaced by —O—, —NR58- or —S(O) wherein the formed ring and the optionally condensed phenyl, heteroaryl, cycloalkyl or heterocyclyl radical can be unsubstituted or substituted by 1, 2, 3, 4 or 5 radicals selected from the group consisting of F, Cl, Br, I, CN, NO R58 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or C(O)R59; R59 is hydrogen, alkyl with 1, 2, 3 or 4 carbon atoms or phenyl; w is 0, 1 or 2; or a pharmaceutically acceptable salt or a prodrug thereof.