Patent ID: 6831074
Filing Date: 2004-12-14
Classification: C07D

Abstract:
A compound of Formula Iaa, having the formula: or a pharmaceutically acceptable salt thereof wherein A represents SO2; X represents N; Y is CH2; n equals 3; Het1 represents a piperazinyl-1-yl group having a substituent R5 at the 4-position of the piperazinyl group wherein said piperazinyl group is optionally substituted with one or two C1 to C4 alkyl groups and is optionally in the form of its 4-N-oxide; R1 and R2 independently represent hydrogen; C1 to C6 alkyl; C1 to C6 alkoxy; C3 to C6 cycloalkyl; C3 to C6 alkenyl; phenyl; heterocyclyl containing one or more atoms from N, S or O, wherein each of the aforementioned substituents may be further substituted with a group selected from â€”CN, â€”NO2, â€”R6, â€”S(O)2R6; â€”NR4R5, â€”OR6; â€”OC(O)(C1 to C4 alkyl); halo; R3 represents C1 to C6 alkyl optionally substituted with one or two substituents selected from C3 to C5 cycloalkyl, hydroxy, C1 to C4 alkoxy, benzyloxy, NR4R5, phenyl, Het2, Het3, Het4 or Het5 wherein the C1 to C6 alkyl and C1 to C4 alkoxy groups may be optionally terminated by a haloalkyl group such as CF3 and wherein the C3-C5 cycloalkyl group may be optionally substituted by C1-C4 alkyl, hydroxy or halo; C3 to C6 cycloalkyl; Het2, Het3, Het4 or Het5; R4 and R5 each independently represents hydrogen; C1 to C4 alkyl optionally substituted with C3 to C5 cycloalkyl or C1 to C4 alkoxy, or, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholinyl group; R6 represents hydrogen; C1 to C4 alkyl optionally substituted with one or two substituents selected from halo, hydroxy, NR4R5, CONR4R5, phenyl optionally substituted with C1 to C4 alkyl or C1 to C4 alkoxy; C3 to C6 alkenyl; C1 to C4 haloalkoxy; or Het5; Het2 represents an N-linked 4-, 5- or 6-membered nitrogen-containing heterocylic group optionally containing one or two further heteroatoms selected from S, N or O; Het3 represents a C-linked 5-membered heterocyclic group containing an O, S or N heteroatom optionally containing one or two further heteroatoms selected from N, O or S; Het4 represents a C-linked 6-membered heterocyclic group containing an O or S heteroatom optionally containing one or two further heteroatoms selected from O, S or N or Het3 is a C-linked 6-membered heterocyclic group containing three N heteroatoms; Het5 represents a C-linked 4-, 5- or 6-membered heterocyclic group containing one, two or three heteroatoms selected from S, O or N; and wherein any of said heterocyclic Het2, Het3, Het4 or Het5 may be saturated, partially unsaturated or aromatic and wherein any of said heterocyclic groups may be optionally substituted with one or more substituents selected from C1 to C4 alkyl, C3 to C4 alkenyl, C1 to C4 alkoxy, halo , COF3, CO2R6, COR6, SO2R6, NHR6 or NHCOR6 and/or wherein any of said heterocyclic groups is benzo-fused.