Patent ID: 6277839
Filing Date: 2001-08-21
Classification: A61P,C07D

Abstract:
A compound of structural Formula II: ##STR38##or a pharmaceutically acceptable salt, crystal form, or hydrate thereof, wherein:A and B are independently unsubstituted, monosubstituted or disubstituted ortho-benzenediyl wherein the substituents are selected from the group consisting of:a) halogen,b) C.sub.1-5 alkyl,c) C.sub.1-5 alkoxy,d) C.sub.1-5 alkylthio,e) nitro,f) CN,g) C.sub.1-5 fluoroalkyl,h) COOR.sup.3, andi) NR.sup.3.sub.2 ;X is CH.sub.2 CH.sub.2 CH.dbd.CH, CH.sub.2 Y or YCH.sub.2 ;Y is O;D is unsubstituted, monosubstituted, or disubstituted benzendiyl wherein the substituents are selected from:a) halogen,b) C.sub.1-5 alkyl,c) C.sub.1-5 alkoxy,d) C.sub.1-5 alkylthio,e) nitro,f) CN,g) C.sub.1-5 fluoroalkyl,h) COOR.sup.3, andi) NR.sup.3.sub.2 ;R is:a) C.sub.1-6 alkyl,b) (CR.sup.1 R.sup.2).sub.n O--Ph,c) (CR.sup.1 R.sup.2).sub.n O-heteroaryl,d) O--(CR.sup.1 R.sup.2).sub.n Ph,e) O--(CR.sup.1 R.sup.2).sub.n heteroaryl,f) NR.sup.3 --(CR.sup.1 R.sup.2).sub.n Ph,g) NR.sup.3 --(CR.sup.1 R.sup.2).sub.n heteroaryl,h) C.sub.2-6 alkenyl-Ph,i) C.sub.2-6 alkenyl-heteroaryl,j) (CR.sup.1 R.sup.2).sub.n Ph, ork) (CR.sup.1 R.sup.2).sub.n heteroaryl,wherein Ph or heteroaryl is unsubstituted, monosubstituted or disubstituted with substituents selected from:1) halogen,2) C.sub.1-5 alkyl,3) C.sub.1-5 alkoxy,4) C.sub.1-5 alkylthio,5) nitro,6) CN,7) C.sub.1-5 fluoroalkyl,8) COOR.sup.3, and9) NR.sup.3.sub.2 ;n=0, 1, 2 or 3;R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-3 alkyl, benzyl, C.sub.1-3 fluoroalkyl, C.sub.1-3 alkoxy,or fluorine;R.sup.3 is H or C.sub.1-6 alkyl.