Patent ID: 6660748
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound having formula (I) or formula (II): and pharmaceutically acceptable derivatives thereof, wherein:X is O, S, C(R1)2 or NR1; y is 2; A and B are independently E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl; wherein 1 or 0.72 hydrogen atoms in said alkyl, alkenyl or alkynyl are independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl; and wherein 1 to 2 methylene (â€”CH2â€”) groups in said alkyl, alkenyl, or alkynyl groups are optionally and independently replaced by â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€”, &boxH;Nâ€”, â€”N&boxH; or â€”N(R3)â€”; R1 is E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl; wherein 1 or 2 hydrogen atoms in said alkyl, alkenyl or alkynyl are optionally and independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl; and wherein 1 to 2 methylene (â€”CH2â€”) groups in said alkyl, alkenyl, or alkynyl groups are optionally and independently replaced by â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O)2â€”, &boxH;Nâ€”, â€”N&boxH;or â€”N(R3)â€”; wherein R3 is selected from hydrogen, (C1-C4)-straight or branched alkyl, (C3-C4)-straight or branched alkenyl or alkynyl, or (C1-C4) bridging alkyl, wherein said bridge is formed between the nitrogen atom to which said R3 is bound and any carbon atom of said alkyl, alkenyl or alkynyl to form a ring, and wherein said ring is optionally benzofused; wherein E is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in E are optionally and independently substituted with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, Oâ€”[(C1-C6)-straight or branched alkyl], Oâ€”[(C3-C6)-straight or branched alkenyl], (CH2)nâ€”N(R4)(R5), (CH2)nâ€”NH(R4)â€”(CH2)n-Z, (CH2)nâ€”N(R4â€”(CH2)n-Z)(R5â€”(CH2)n-Z), (CH2)n-Z, Oâ€”(CH2)n-Z, (CH2)nâ€”O-Z, Sâ€”(CH2)n-Z, CH&boxH;CH-Z, 1,2-methylenedioxy, C(O)OH, C(O)Oâ€”[(C1-C6)-straight or branched alkyl], C(O)Oâ€”(CH2)n-Z or C(O)â€”N(R4)(R5); wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S; wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z; each n is independently 0 to 4; each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in Z are optionally and independently substituted with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, O-(C1-C3)-straight or branched alkyl, C(O)Oâ€”[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or Nâ€”[(C1-C3)-straight or branched alkyl]2; wherein 1 to 4 hydrogen atoms in the bicyclic ring of formula (I) or formula (II) are optionally and independently substituted with Q; wherein Q is selected from E, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E; wherein Q is optionally substituted with up to 3 substituents selected from halogen, OH, O-(C1-C6)-alkyl, Oâ€”(CH2)n-Z, NO2, CO2H, C(O)â€”Oâ€”(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)n-Z; and wherein the ethylene groups adjacent to the nitrogen atom in the bicyclic rings of formula (I) and formula (II) are optionally be benzo fused.