Patent ID: 6262088
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of the following formulae: ##STR17##wherein;Z.sup.1 is --O-- or --S(O).sub.n -- (where n is 0 to 2);Z.sup.2 is --O-- or --S(O).sub.n -- (where n is 0 to 2);R.sup.1 and R.sup.4 are each independently hydrogen, halo, alkyl or --OR.sup.9 ;R.sup.2 is --C(NH)NH.sub.2 ;R.sup.3 is (1,2)-imidazolinyl (optionally substitute by alkyl);R.sup.5 and R.sup.6 are independently hydrogen, halo, alkyl, or haloalkyl;R.sup.7 is --X--CH.sub.2 --[C(R.sup.13)H].sub.p --C(R.sup.13)H.sub.2 or --X--C([C(R.sup.13)H].sub.p --C(R.sup.13)H.sub.2).sub.2 H where:p is 0 to 5;X is --O-- or --S(O).sub.n -- (where n is 0 to 2);and each R.sup.13 is independently --[CH.sub.2 ].sub.n --OR.sup.9, --[CH.sub.2 ].sub.n --SR.sup.9 or --[CH.sub.2 ].sub.n --N(R.sup.9)R.sup.10 (where each n is independently 0 to 2);or R.sup.7 is selected from the group consisting of the following formulae: ##STR18##whereq is 0 to 4;p is 0 to 5;each R.sup.13 is independently --[C(OR.sup.9)H].sub.m --CH.sub.2 --OR.sup.9 (where m is 1 to 4) or --[CH.sub.2 ].sub.n --OR.sup.9 (where n is 0 to 2); andeach R.sup.14 is --O--[CH.sub.2 ].sub.r -- (where r is 0 to 5); andeach R.sup.9 and R.sup.10 is independently hydrogen or alkyl;as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.