Patent ID: 7749986
Filing Date: 2010-07-06
Classification: A61K,A61P

Abstract:
1. A method for essentially homogeneously formulating as an ointment a microdose of at least one active principle within at least one excipient therefor utilizing a container having an inner surface, an open top and a perforated bottom, wherein said perforated bottom comprises a plurality of perforations having a size and shape as to permit diffusion of a molten mixture of said active principle(s) and petroleum jelly through said perforations, comprising the following steps: (a) weighing said at least one active principle contained in said container, wherein said container contains a layer of a petroleum jelly, wherein said layer of petroleum jelly encloses the bottom of said container and at least partially lines the inner surface of said container; (b) encapsulating said active principle with additional petroleum jelly; (c) introducing said container containing said active principle(s) and said petroleum jelly into a mixer, said container having a perforated plug connected to the top of said container, and said mixer containing at least one excipient in heated liquid state; and (d) melting said petroleum jelly by immersion of said container within said at least one excipient being in a heated liquid state and thence diffusing and microdosing said active principle(s) therein.