Patent ID: 9206243
Filing Date: 2015-12-08
Classification: A61K,A61P,C07K

Abstract:
1. An agonist polypeptide of IL-2, characterized by 95% homology with the sequence of native wild-type human IL-2 and wherein said polypeptide is at least 1000 times less effective in stimulating in vitro and/or in vivo regulatory T cells and shows greater in vivo therapeutic efficacy, wherein the polypeptide is selected from the group consisting of: (i) the polypeptide comprising the sequence of SEQ ID NO 1; (ii) the polypeptide comprising the sequence of SEQ ID NO 2; (iii) the polypeptide comprising the sequence of SEQ ID NO 3; (iv) the polypeptide comprising the sequence of SEQ ID NO 4; (v) the polypeptide comprising the sequence of SEQ ID NO 5; (vi) the polypeptide comprising the sequence of SEQ ID NO 6.