Patent ID: 8178292
Filing Date: 2012-05-15
Classification: A61P,C07K

Abstract:
1. A method of diagnosing acute myeloid leukemia (AML) in a human subject, which comprises: obtaining from the human subject a sample which comprises nucleic acid, wherein the nucleic acid comprises genomic DNA, cDNA or RNA; detecting from the sample an isolated nucleic acid which encodes human FLT3 kinase, or detecting from the sample an isolated nucleic acid fragment of a nucleic acid which encodes human FLT3 kinase, wherein said isolated nucleic acid or said isolated nucleic acid fragment comprises at least one in frame tandem duplication located within the nucleic acid region encoding a juxtamembrane domain of human FLT3 kinase, said nucleic acid region is amplified by primers SEQ ID NO: 26 and SEQ ID NO: 27, wherein said isolated nucleic acid and said isolated nucleic acid fragment are markers for AML; and diagnosing AML in the human subject based on the presence of the in frame tandem duplication in the isolated nucleic acid or nucleic acid fragment.