Patent ID: 6358491
Filing Date: 2002-03-19
Classification: A61K,A61P,C07K

Abstract:
A compound comprising a somatostatin receptor-binding peptide having a formulacyclo-B1-B2-B3-B4-C-A whereinB1 is Phe, Tyr, Nal, Ain, or a substituted derivative thereof; B2 is Trp or a substituted derivative thereof; B3 is Lys, Hly, Achxa, Amf, Aec, Apc, Aes, Aps or a substituted derivative thereof; B4 is Thr, Ser, Val, Phe, Ile, Abu, Nle, Leu, Nva, or Aib; C is an L-&agr;-amino acid; A is an N-alkyl-&agr;-amino acid or an N-substituted alkyl-&bgr;-amino acid, wherein A comprises a sidechain containing a sulfur atom; wherein A and B1 are covalently linked though an amino terminus of B1 and a carboxyl terminus of A to form a cyclic peptide.