Patent ID: 7662585
Filing Date: 2010-02-16
Classification: A61K,C07K,Y02A

Abstract:
1. An isolated nucleic acid molecule encoding a polypeptide that binds ErbB4 receptor, which polypeptide is selected from the group consisting of: (a) a polypeptide comprising the amino acid sequence of the extracellular domain of neuregulin 3 (NRG3) encoded by SEQ ID NO: 3 or SEQ ID NO: 7; (b) a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 6; and (c) a soluble form of any of the polypeptides (a)-(b), devoid of a transmembrane domain that can anchor the polypeptide in a cell membrane and otherwise retaining the sequence of SEQ ID NO: 2 up to amino acid 362, with or without a cytoplasmic domain, without an N-terminal hydrophobic segment and with or without the remainder of a native signal sequence, or SEQ ID NO: 6 up to amino acid 360, with or without a cytoplasmic domain, without an N-terminal hydrophobic segment, and with or without the remainder of a native signal sequence.