Patent ID: 7605149
Filing Date: 2009-10-20
Classification: A61K,A61P

Abstract:
1. A method of modifying beta-amyloid-induced vasoactivity in individuals with Alzheimer's Disease or other vascular-related diseases or disorders, in which said vascular-related diseases or disorders are selected from the group consisting of cerebral amyloid angiopathy, vascular amyloidosis, hypertension and vasospasm associated with severe post-traumatic head injury, comprising antagonizing the secretory phospholipase A2/arachidonic acid/5-lipoxygenase/cyclo-oxygenase-2 pro-inflammatory pathway by administering a pharmaceutically effective amount of oleyloxyethylphosphocholine to the individual in an amount ranging from between 0.1 μg to 10 mg/kg body weight/day.