Patent ID: 7635716
Filing Date: 2009-12-22
Classification: A61K,A61P,C07C

Abstract:
1. A compound represented by a formula: or a pharmaceutically acceptable salt thereof; wherein Y is selected from the group consisting of CO 2 (R 2 ), CON(R 2 ) 2 , CON(OR 2 )R 2 , CON(CH 2 CH 2 OH) 2 , CONH(CH 2 CH 2 OH), CH 2 OH, P(O)(OH) 2 , CONHSO 2 R 2 , SO 2 N(R 2 ) 2 , SO 2 NHR 2 , and tetrazolyl-R 2 ; wherein R 2 is independently H, C 1 -C 6 alkyl, phenyl, or biphenyl; A is —(CH 2 ) 6 —, cis —CH 2 CH═CH—(CH 2 ) 3 —, or —CH 2 C≡C—(CH 2 ) 3 —, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is —(CH 2 ) m —Ar—(CH 2 ) o —wherein Ar is interphenylene, the sum of m and o is from 1 to 4, and wherein one CH 2 may be substituted with S or O; B is C═O, CH G is OH or H; and D is substituted or unsubstituted phenyl, naphthyl, furan, thiophene, pyridine, benzothiophene, or benzofuran.