Patent ID: 6123964
Filing Date: 2000-09-26
Classification: A61K

Abstract:
A pharmaceutical composition comprising:0.1 to 50% by weight of an active ingredient N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-y l)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide, or a pharmaceutically acceptable salt thereof;20 to 40% by weight of a binder/diluent which is selected from: hydroxypropyl methylcellulose, hydroxypropyl cellulose, pregelatinized starch and polyvinylpyrrolidone;10 to 20% by weight of a first diluent which is selected from: lactose, microcrystalline cellulose, calcium phosphate dibasic, mannitol, powdered cellulose and pregelatinized starch;20 to 50% by weight of a second diluent which is selected from: lactose, microcrystalline cellulose, calcium phosphate dibasic, mannitol, powdered cellulose and pregelatinized starch;5 to 15% by weight of a disintegrant which is selected from microcrystalline or croscarmellose sodium; and0.05 to 5% by weight of a lubricant which is selected from magnesium stearate, calcium stearate, and steric acid;wherein sum of the above proportions of the active ingredient, the binder/diluent, the first diluent, the second diluent, the disintegrant, and the lubricant are not greater than 100% by weight.