Patent ID: 6291499
Filing Date: 2001-09-18
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR157##or a pharmaceutically acceptable salt thereof, whereinR.sub.1 is 2-benzimidazole, optionally substituted with fluoro, amino, or hydroxy;R.sub.2 is phenyl, optionally substituted with one to five substituents, each substituent independently being chloro, fluoro, bromo, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, hydroxy, or carboxy;L.sub.1 and L.sub.2 are independently C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkynyl, C.sub.1 -C.sub.4 alkoxy, amino, aminoC.sub.1 -C.sub.4 alkyl, hydroxyC.sub.1 -C.sub.4 alkyl, carbonyl, cycloC.sub.3 -C.sub.6 alkyl or aminocarbonyl;A.sub.1, A.sub.2, and A.sub.3 are each hydrogen or i) A.sub.1 and A.sub.2 form a two carbon bridge or ii) A.sub.1 and A.sub.3 form a two carbon bridge; andoptionally substituted with X, wherein X is hydroxy, amino, C.sub.1 -C.sub.4 alkylamino, di(C.sub.1 -C.sub.4)alkylamino, C.sub.1 -C.sub.4 alkyl, ester, carbamate, carbonate, or ether.