Patent ID: 6107064
Filing Date: 2000-08-22
Classification: C07D,C12P

Abstract:
A process for producing a xanthine derivative, comprising the steps of:selecting a compound according to formula (I): ##STR30## wherein R.sup.1 and R.sup.2 are independently hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl;selecting an enzyme source for catalyzing hydroxylation or carbonylation of said compound according to formula (I), wherein said enzyme source is produced by a microorganism selected from the group consisting of a bacterium and a fungus;admixing said compound according to formula (I) with said enzyme source for catalyzing hydroxylation or carbonylation of said compound according to formula (I) so as to convert said compound according to formula (I) into a compound according to formula (II): ##STR31## wherein R.sup.3 and R.sup.4 are independently hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl; R.sup.5 and R.sup.6 are independently hydrogen, hydroxy, or oxo, with the proviso that R.sup.5 and R.sup.6 are not simultaneously hydrogen; and X and Y are both hydrogen or are combined with each other to form a single bond; andrecovering the compound according to formula (II) produced thereby.