Patent ID: 7927519
Filing Date: 2011-04-19
Classification: A61B,B29C,B29D,B29L,G01N,G03H

Abstract:
1. A method for making a biocompatible sensor containing a reflection hologram, comprising the steps of: introducing a crosslinkable and/or polymerizable fluid material into a cavity formed by a mold, wherein the crosslinkable and/or polymerizable fluid material comprises at least a molecular sensing moiety which can interact or react with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram, wherein the mold has a first mold half defining a first molding surface and a second mold half defining a second molding surface, wherein said first mold half and said second mold half are configured to receive each other such that the cavity is formed between said first molding surface and said second molding surface, wherein the second mold half has, on or behind the second molding surface, a mirror to reflect incident light coming from the first molding surface; and producing and recording a pattern of interference fringes while polymerizing/crosslinking said crosslinkable and/or polymerizable fluid material in the cavity by directing an incident beam of coherent light through the first molding surface to said crosslinkable and/or polymerizable fluid material and to said mirror, wherein the incident beam and a beam reflected by the mirror form said pattern while polymerizing/crosslinking said crosslinkable and/or polymerizable fluid material to form the biocompatible sensor, whereby said pattern is recorded in said biocompatible sensor to form the reflection hologram.