Patent ID: 7026313
Filing Date: 2006-04-11
Classification: A61P,C07D

Abstract:
1. A compound of the formula I wherein: R (a) hydrogen; (b) lower alkyl optionally substituted with one, two, or three groups independently selected from halogen, hydroxy, lower alkoxy, amino, mono- or dialkylamino, carboxy, alkoxycarbonyl, thioalkyl, nitrile, aryl, heteroaryl containing one or more aromatic ring systems of 5-, or 6-membered rings containing at least one and up to four heteroatoms selected from nitrogen, oxygen, or sulfur, or a carbocyclic cycloalkyl group containing from 3–7 members, up to two of which members are optionally heteroatoms independently selected from oxygen, sulfur, and nitrogen; or (c) a cycloalkyl group containing from 3–7 members, up to two of which members are optionally heteroatoms independently selected from oxygen, sulfur, and nitrogen, wherein the cycloalkyl group is unsubstituted or substituted with one, two, or three groups independently selected from halogen, hydroxy, lower alkyl, lower alkoxy, amino, mono- or dialkylamino, aryl, and heteroaryl containing one or more aromatic ring systems of 5-, or 6-membered rings containing at least one and up to four heteroatoms selected from nitrogen, oxygen, or sulfur; R wherein R E is C or N; and R Y is N or CR R wherein R X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, —NR m is 0–6; T is O, S, NR Q is O, S, NR R Each of R n is 0–2; Each of R a pharmaceutically acceptable salt thereof.