Patent ID: 6262254
Filing Date: 2001-07-17
Classification: C07D

Abstract:
An 8-fluoropurine compound of the formula: ##STR3##where X is alkyl, aryl, arylalkyl, alkoxy, aryloxy, acetylamino, amino, carbamoyl, alkoxyamino, aryloxyamino, alkylcarbonylamino, alkoxyacetylamino, aryloxyacetylamino, benzoylamino, tritylamino, halogen, or hydrogen,Y is alkyl, aryl, arylalkyl, alkoxy, aryloxy, acetyl, amino, secondary amino, tertiary amino, protected amino, carbamoyl, alkoxyamino, aryloxyamino, alkylcarbonylamino, alkoxyacetylamine, aryloxyacetylamino, benzoylamino, tritylamino, halogen, hydroxy, or hydrogen,R is alkyl, aryl, arylalkyl, hydrogen, hydroxyalkoxy lower alkyl, or protected hydroxyalkoxy lower alkyl,where each alkyl or aryl moiety independently is unsubstituted or substituted with one or more of hydroxy, halogen, lower alkyl or lower alkoxy;and provided that when X is hydrogen and Y is hydrogen, R is not methyl; and tautomers thereof.