Patent ID: 8481560
Filing Date: 2013-07-09
Classification: A61K,A61P,Y10T

Abstract:
1. An abuse-resistant patch for transdermally delivering an opioid to a subject, comprising: (a) a backing layer; (b) a first layer underlying the backing layer, the first layer comprising: an opioid antagonist or opioid antagonist prodrug which is not transdermally delivered at therapeutic levels when the patch is used for transdermally administering the opioid to the subject; wherein the backing layer is substantially impermeable to the opioid antagonist or opioid antagonist prodrug of the first layer; (c) a second layer underlying the first layer, the second layer comprising: (d) a barrier layer located between the first and second layer, the barrier layer comprising: a water-insoluble polymeric material and a water-soluble polymer; wherein the release ratio is between about 1:60 and about 60:1 after the patch has been placed in ethanol, water or a phosphate buffer having a pH of about 6.5 for greater than about 30 seconds.