Patent ID: 8039010
Filing Date: 2011-10-18
Classification: A61K,A61P,C07K

Abstract:
1. A sustained release, biodegradable intraocular implant comprising a) about 70-85% by weight of a biodegradable polymeric carrier, wherein the biodegradable polymeric carrier is a poly-lactide-co-glycolide (PLGA) co-polymer; b) about 10-20% by weight of a water soluble therapeutic agent, wherein the therapeutic agent is an inhibitor of vascular endothelial growth factor (VEGF) selected from the group consisting of ranibizumab, bevacizumab, mixtures of ranibizumab and bevacizumab, pegaptanib, and an siRNA molecule; and c) about 5-10% by weight of a long chain fatty alcohol comprising from between 10 to 40 carbon atoms; wherein a therapeutically effective amount of the therapeutic agent is released from the biodegradable intraocular implant for at least one week after the intraocular implant is placed in the eye.