Patent ID: 6702851
Filing Date: 2004-03-09
Classification: A61F,A61L

Abstract:
A method for reducing calcification and thrombus formation in a biocompatible heart valve comprising a polymer selected from the group consisting of silicone rubbers, polyurethane, and polyetherurethane, said method comprising:coating, prior to implantation, said heart valve including its leaflets with a coating derived from a compound of the formula: X-Y-Z wherein X is a photochemically reactive group capable upon activation of bonding to the surface of the heart valve, Y represents nothing or a relatively inert, noninterfering skeletal moiety joining groups X and Z and is resistant to cleavage in aqueous physiological fluids, and Z is a fatty acid moiety, said coating being effective to reduce calcification and thrombus formation after implantation.