Patent ID: 6297399
Filing Date: 2001-10-02
Classification: A61P,C07C

Abstract:
A compound of one of the formula: ##STR19##wherein X is a bond or NR wherein R is H, acyl, alkyl, allyl, benzyl or a sulphonate group,in Formula 7 each of R.sup.8, R.sup.9, .sup.1 R.sup.9, R10, .sup.1 R.sup.10, R.sup.11, .sup.1 R.sup.11, R.sup.12, .sup.1 R.sup.12 and R.sup.13 and in Formula 8 each of R.sup.8, R.sup.9, .sup.1 R.sup.9, R.sup.10, .sup.1 R.sup.10, R.sup.11, .sup.1 R.sup.11, R.sup.12, .sup.1 R.sup.12 and R.sup.13 is a member independently selected from the group consisting of H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro, carbonyl, amino, amido, alkylamino, hydroxylamino, optionally-substituted and optionally unsaturated C.sub.1 -C.sub.10 alkyl, and optionally substituted and optionally unsaturated C.sub.8 -C.sub.8 cycloalkyl,in Formula 8, R.sup.1, .sup.1 R.sup.1 represents H, OH; OAc,in Formula 7 any one or more pairs of R.sup.9, .sup.1 R.sup.9 ; R.sup.10, .sup.1 R.sup.10 ; R.sup.11, .sup.1 R.sup.11 ; R.sup.12 ; .sup.1 R.sup.12 optionally together represent oxo, andin Formula 8 any one or more of R.sup.1, .sup.1 R.sup.1 ; R.sup.9, .sup.1 R.sup.9 ; R.sup.10, R.sup.1 R.sup.10 ; R.sup.11, .sup.1 R.sup.11 ; R.sup.12, .sup.1 R.sup.12 optionally together represent oxo; ora pharmacologically acceptable salt, ester, amide, solvate or isomer thereof.