Patent ID: 6589956
Filing Date: 2003-07-08
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein:Ra represents a hydroxy, alkoxy, optionally substituted aryloxy or optionally substituted arylalkyloxy, amino, alkylamino, dialkylamino, optionally substituted arylamino or optionally substituted arylalkylamino group, A represents: either a CH group, in which case R1 represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, optionally substituted arylcarbonyl, optionally substituted arylcarbonylalkyl, optionally substituted aryloxy, optionally substituted aryloxyalkyl, optionally substituted arylthio, optionally substituted arylthioalkyl, optionally substituted arylamino, optionally substituted arylalkylamino, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylcarbonyl, optionally substituted heteroarylcarbonylalkyl, optionally substituted heteroaryloxy, optionally substituted heteroaryloxyalkyl, optionally substituted heteroarylthio, optionally substituted heteroarylthioalkyl, optionally substituted heteroarylamino or optionally substituted heteroarylalkylamino group, or a nitrogen atom, in which case R1 represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, optionally substituted arylcarbonyl, optionally substituted arylcarbonylalkyl, optionally substituted arylsulphonyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylcarbonyl, optionally substituted heteroarylcarbonylalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted heteroarylsulphonyl or optionally substituted heteroarylthioalkyl group, or R1â€”A together represent an oxygen atom or a group â€ƒwherein R3 and R4, which may be identical or different, each represents a hydrogen atom, an optionally substituted aryl group, an alkyl group or an optionally substituted heteroaryl group, R2 being a hydrogen atom or an alkyl group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, n is an integer of from 2 to 6 inclusive m and p are identical or different integers of from 0 to 6 inclusive, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, wherein:the term â€œalkylâ€  denotes a linear or branched chain having from 1 to 6 carbon atoms, the term â€œalkoxyâ€  denotes a linear or branched alkyl-oxy group having from 1 to 6 carbon atoms, the term â€œtrihaloalkylâ€  denotes a carbon chain having from 1 to 3 carbon atoms and from 1 to 3 identical or different halogen atoms, the term â€œcycloalkylâ€  denotes a saturated cyclic group having from 3 to 8 carbon atoms, the term â€œarylâ€  denotes a phenyl or naphthyl group, the term â€œheteroarylâ€  is selected from benzisoxazolyl, benzothienyl, and benzisothiazolyl, the term â€œsubstitutedâ€  relating to aryl, arylcarbonyl, arylcarbonylalkyl, aryloxy, aryloxyalkyl, arylthio, arylthioalkyl, arylamino, arylalkylamino, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heteroarylcarbonylalkyl, heteroaryloxy, heteroaryloxyalkyl, heteroarylthio, heteroarylthioalkyl, heteroarylamino, and heteroarylalkylamino, arylsulphonyl, arylsulphonylalkyl, heteroarylsulphonyl and heteroarylsulphonylalkyl, wherein the â€œsubstitutedâ€  aromatic groups are substituted in the aromatic moiety by one or two identical or different substituents selected from halogen atoms, alkyl groups, alkoxy groups, hydroxy groups, cyano groups, nitro groups, amino groups (optionally substituted by one or two alkyl groups) and group C(O)Rd, wherein Rd represents a group selected from hydroxy, alkoxy and amino, and wherein the heteroaryl and heteroarylalkyl groups may also be substituted by an oxo group in the non-aromatic moiety of the heteroaryl.