Patent ID: 6291664
Filing Date: 2001-09-18
Classification: A61K,A61P,C07K,C12N

Abstract:
A nucleic acid construct, wherein said nucleic acid construct comprises a nucleic acid sequence capable of producing HIV Env protein in the absence of HIV Rev protein, and wherein said nucleic acid sequence comprises multiple point mutations which decrease the effect of an inhibitory/instability sequence which is present in the corresponding nucleic acid sequence of the native IRV env gene between nucleotides selected from the group consisting of5606 and 6014;6004 and 6435;6435 and 6878;6879 and 7266;7266 and 7924;8021 and 8561;5606 and 6435;5606 and 6878;and 6879 and 7924;using the using the numbering of the nucleotide sequence of the HIV-1 molecular clone pHXB2.