Patent ID: 7608595
Filing Date: 2009-10-27
Classification: C07H

Abstract:
1. A compound of formula that has the S-configuration at the 4″-position and wherein the bond between carbon atoms 22 and 23 is a single or a double bond; R R R X is a bond, O, NR Z is C═O, C═S or SO R R wherein the substituents of the mentioned alkyl, alkeny, alkynyl, cycloalkyl, alkylene, alkenylene, aryl radicals as defined under R 2 , R 3 and R 4 are selected from the group consisting of OH, ═O, halogen, halo-C 1 -C 2 alkyl, CN, NO 2 , —N 3 , C 3 -C 8 cycloalkyl that is unsubstituted or substituted by from one to three methyl groups; norbornylenyl; C 3 -C 8 cycloalkenyl that is unsubstituted or substituted by from one to three methyl groups; C 3 -C 8 halocycloalkyl, C 1 -C 12 alkoxy, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, C 3 -C 8 cycloalkoxy, C 1 -C 12 haloalkoxy, C 1 -C 12 alkythio, C 3 -C 8 cycloalkylthio, C 1 -C 12 haloalkylthio, C 1 -C 12 alkylsulfinyl, C 3 -C 8 cycloalkylsulfinyl, C 1 -C 12 haloalkylsulfinyl, C 3 -C 8 halocycloalkylsulfinyl, C 1 -C 12 alkylsulfonyl, C 3 -C 8 cycloalkylsulfonyl, C 1 -C 12 haloalkylsulfonyl, C 3 -C 8 halocycloalkylsulfonyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —C(═O)R 5 , —NHC(═O)R 6 , ═NO—C 1 -C 6 alkyl, —P(═O)(OC 1 -C 6 alkyl) 2 ; aryl, pyridyl, pyrimidyl, s-triazinyl, 1,2,4-triazinyl, thienyl, furyl, tetrahydrofuranyl, pyranyl, tetrahydropyranyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, triazolyl, oxazolyl, thiadiazolyl, oxadiazolyl, benzothienyl, quinolinyl, quinoxalinyl, benzofuranyl, benzimidazolyl, benzopyrrolyl, benzothiazolyl, indolyl, coumarinyl, indazolyl, aryloxy; and aryl, pyridyl, pyrimidyl, s-triazinyl, 1,2,4-triazinyl, thienyl, furyl, tetrahydrofuranyl, pyranyl, tetrahydropyranyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, thiadiazolyl, oxadiazolyl, benzothienyl, quinolinyl, quinoxalinyl, benzofuranyl, benzimidazolyl, benzopyrrolyl, benzothiazolyl, indolyl, coumarinyl, indazolyl, and aryloxy that, depending upon the possibilities of substitution at the ring, are mono- to penta-substituted by substituents selected from the group consisting of OH, ═O, halogen, CN, NO 2 , —N 3 , C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 12 haloalkyl, C 1 -C 12 alkoxy, C 1 -C 12 haloalkoxy, C 1 -C 12 alkylthio, C 1 -C 12 haloalkylthio, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, dimethylamino-C 1 -C 6 alkoxy, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, phenoxy and phenyl-C 1 -C 6 alkyl; phenoxy that is unsubstituted or substituted by from one to three substituents selected independently of one another from halogen, methoxy, trifluoromethyl and trifluoromethoxy; phenyl-C 1 -C 6 alkoxy that is unsubstituted or substituted in the aromatic ring by from one to three substituents selected independently of one another from halogen, methoxy, trifluoromethyl and trifluoromethoxy; phenyl-C 2 -C 6 alkenyl, phenyl-C 2 -C 6 alkynyl, methylenedioxy, —C(═O)R 5 ,—O—C(═O)R 8 , —NH—C(═O)R 6 , NH 2 , NH(C 1 -C 12 alkyl), N(C 1 C 12 alkyl) 2 , C 1 -C 6 alkylsulfinyl, C 3 -C 8 cycloalkylsulfinyl, C 1 -C 6 haloalkylsulfinyl, C 3 -C 8 halocycloalkylsulfinyl, C 1 -C 6 alkylsulfonyl, C 3 -C 8 cycloalkylsulfonyl, C 1 -C 6 haloalkylsulfonyl and C 3 -C 8 halocycloalkylsulfonyl; R R R or, where applicable, an E/Z isomer, a mixture of E/Z isomers and/or a tautomer, in each case in free form or in salt form; with the proviso that Z is not C═O when X is a bond, R