Patent ID: 7230072
Filing Date: 2007-06-12
Classification: C07K

Abstract:
1. A method for site-selective acyl transfer in or amidation of folded polypeptides and proteins comprising bringing the polypeptide or protein in contact with an acyl group donor, wherein: said polypeptide or protein comprises a helical secondary structure, said helical secondary structure comprises a histidine in position i flanked by at least one amino group to be amidated in position i+3+4k, wherein k is −1, 0, 1, or in position i−4−4n, wherein n is 0, 1 or 2, said polypeptide or protein further comprises at least one serine, threonine, tyrosine, or cysteine in position i+4+4n or i−3−4n, respectively, wherein n is 0, 1 or 2, and i is the position of an amino acid.