Patent ID: 8598191
Filing Date: 2013-12-03
Classification: A61K,A61P

Abstract:
1. A once-daily oral pharmaceutical dosage form, comprising: (a) a solid immediate release component comprising a gamma-hydroxybutyric acid (GHB) salt, (b) a first delayed release component comprising the GHB salt, and (c) a second delayed release component comprising the GHB salt, wherein the first delayed release component releases GHB in the duodenum and comprises a GHB containing core surrounded by a barrier coat, which in turn is surrounded by an enteric coating comprising a pH sensitive material that dissolves in the duodenum, and wherein the second delayed release component releases GHB in the colon and comprises a GHB containing core surrounded by a barrier coat, which in turn is surrounded by a coating comprising a pH sensitive material that dissolves in the colon.