Patent ID: 9132098
Filing Date: 2015-09-15
Classification: A61K,A61P

Abstract:
1. A stable self-assembled composition comprising (i) a carrier and targeting system comprising nanoparticles formed by self-assembly of an optionally modified polyanion, and optionally a polycation, which may also be modified, said nanoparticles having a surface; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both, or to the surface of the nanoparticle; (ii) an active compound selected from the group of doxorubicin and its pharmaceutically acceptable salts covalently bound to the polycation and/or the polyanion; (iii) a PEGylating agent; and optionally (iv) at least one complexing agent, metal ion, or stabilizer/formulating agent, wherein the nanoparticles are coated with PEG, and/or PEG-chain containing targeting agent at the end of the chain.