Patent ID: 6458793
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound of the formula I wherein:A is an optionally substituted 5- or 6-membered monocyclic aromatic ring consisting of 1, 2 or 3 ring heteroatoms selected from oxygen, nitrogen and sulphur atoms; one of B1, B2, B3 and B4 is nitrogen and the remainder of B1, B2, B3 and B4 are CH, and wherein the ring formed from B1, B2, B3 and B4 may optionally be substituted by one or two substituents selected from hydroxy, carboxy, (1-4C)alkoxycarbonyl or one of the following: -(CH2)n-R, -(CH2)n-NRR1, â€”COâ€”R, â€”COâ€”NRR1, -(CH2)n-COâ€”R and -(CH2)n-COâ€”NRR1; wherein n is 1 or 2; R and R1 are independently selected from hydrogen, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, hydroxy (1-4C)alkyl, carboxy(1-4C)alkyl and (1-4C)alkoxycarbonyl-(1-4C)alkyl, or R and R1 may together form a 5- or 6-membered optionally substituted heterocyclic ring which may include in addition to the nitrogen atom to which R and R1 are attached one or two additional heteroatoms selected from nitrogen, oxygen and sulphur; T1 is CH or N; T2 is CH or N; with the proviso that at least one of T1 and T2 is N; X1 is SO, SO2, C(R4)2 or CO when T1 is CH or N; or in addition X1 is O or S when T1 is CH; and wherein each R4 is independently hydrogen or (1-4C)alkyl; L1 is (1-4C)alkylene or (1â€”3C)alkylenecarbonyl; R2 is hydrogen or (1-4C)alkyl; R3 is hydrogen or (1-4C)alkyl; or R2 and R3 are joined to form a C1-4alkylene or â€”CH2COâ€” group; wherein the ring formed by T1, R2, R3, T2 and L1 is optionally substituted; X2 is SO2; and Q is phenyl, naphthyl, phenyl(1-4C)alkyl, phenyl(2-C)alkenyl, phenyl(2-4C)alkynyl or a heterocyclic moiety containing up to 4 ring heteroatoms selected from nitrogen, oxygen and sulphur and Q is optionally substituted; or a pharmaceutically acceptable salt thereof.