Patent ID: 6451759
Filing Date: 2002-09-17
Classification: A61K,C07K

Abstract:
An isolated polypeptide having at least 80% sequence identity with the amino acid sequence of SEQ ID NO:1 and a capacity to activate a Fas receptor-mediated pathway, said amino acid sequence differing from the sequence of SEQ ID NO:1 by at least one mutation within a Fas ligand (FasL) protease recognition region within SEQ ID NO:1, said FasL protease recognition region comprising an amino acid sequence within SEQ ID NO:1, whereby under conditions that would result in cleavage of FasL from a cell, the mutation inhibits proteolytic cleavage of the polypeptide from a cell membrane under conditions which would result in proteolytic cleavage of a polypeptide having an amino acid sequence of SEQ ID NO:1 from a cell membrane.