Patent ID: 6066292
Filing Date: 2000-05-23
Classification: A61K,A61L,A61P

Abstract:
A method for sterilizing a pharmaceutical suspension of a water-insoluble pharmaceutical, comprising the steps of:(a) heat-sterilizing an aqueous solution of a viscosity enhancer, to result in a first sterile pre-mix;(b) sterile-filtering an aqueous solution of a mixture of a pharmaceutically-active compound, which results in a second sterile pre-mix;(c) heat-sterilizing a mixture of water, a water-insoluble pharmaceutical, and at least a partial amount of an electrolyte to provide a sub-saturated solution of said electrolyte, and adding under aseptic conditions an aqueous surfactant, to give a third sterile pre-mix;(d) combining all three pre-mixes in sterile fashion to achieve a sterile suspended pharmaceutical formulation.