Patent ID: 7736672
Filing Date: 2010-06-15
Classification: A61K

Abstract:
1. A process for making drug-containing multiparticulates comprising the steps: (a) forming multiparticulates comprising a drug, a pharmaceutically acceptable carrier, and an poloxamer, said carrier having a melting point of T (b) treating said multiparticulates of step (a) by at least one of (i) heating said multiparticulates to a temperature of at least 35° C. and less than (T wherein step (b) is conducted for a period of time sufficient to achieve a degree of crystallinity of said drug in said multiparticulates that is greater than the crystallinity of said drug in a control composition consisting essentially of the untreated multiparticulates of step (a) and wherein said carrier is a mixture of glyceryl mono-, di-, and tribehenates.