Patent ID: 7507421
Filing Date: 2009-03-24
Classification: A61K,C07C

Abstract:
1. A method of making a hydroxycitric acid salt composition comprising: (a) preparing an aqueous extract of (b) treating said quaternizing agent extract with potassium hydroxide or sodium hydroxide and recovering a potassium hydroxycitric acid salt solution or a sodium hydroxycitric acid salt solution; (c) treating said potassium or sodium hydroxycitric acid salt solution with activated charcoal such that a decolorized potassium or sodium hydroxycitric acid salt solution is obtained; (d) treating said decolorized potassium or sodium hydroxycitric acid salt solution with a calcium salt such that a heterogeneous slurry comprising insoluble calcium hydroxycitric acid salt precipitate is obtained, wherein said treating comprises adjusting the pH of said decolorized solution to a pH in the range of 9.5-11; (e) washing and drying said precipitate to yield a powder comprising the calcium salt of hydroxycitric acid; (f) obtaining an aqueous solution comprising the potassium salt of hydroxycitric acid, prepared as in (a)-(c); (g) dissolving said powder comprising the calcium salt of hydroxycitric acid in said potassium hydroxycitric acid salt solution to provide a potassium-calcium hydroxycitric acid salt solution, wherein said dissolving comprises combining said calcium hydroxycitric acid salt and said potassium hydroxycitric acid salt solution in a molar ratio in the range of about 1.9-2.9 calcium hydroxycitric acid salt: about 0.9-1.4 potassium hydroxycitric acid salt; (h) drying said potassium-calcium hydroxycitric acid salt solution to yield a powder comprising a mixture of potassium hydroxycitric acid salt and calcium hydroxycitric acid salt.