Patent ID: 7005500
Filing Date: 2006-02-28
Classification: A01K,A61K,A61P,C07K,C12Q,G01N

Abstract:
1. An isolated polypeptide: a) comprising the amino acid sequence of SEQ ID NO: 20; b) comprising a fragment of at least 175 consecutive amino acids of SEQ ID NO:20, wherein said fragment spans the amino acids at positions 219 to 234 of SEQ ID NO:20 and said fragment has a biological activity selected from the group consisting of regulating cell mobility, regulating cell proliferation, regulating bone remodeling, regulating tissue remodeling and regulating metalloproteinase production; c) comprising the OsteoAngioRemodeling (OAR) polypeptide amino acid sequence encoded by the cDNA of deposited clone 106-030-2-0-A3-F (ATCC PTA-2732); d) consisting of an amino acid sequence that has at least 90%, 95%, 96%, 97%, 98% or 99% identity to the sequence of SEQ ID NO: 20, wherein said amino acid sequence has a biological activity selected from the group consisting of regulating cell mobility, regulating cell proliferation, regulating bone remodeling, regulating tissue remodeling and regulating metalloproteinase production; e) comprising an amino acid sequence that has at least 90%, 95%, 96%, 97%, 98% or 99% identity to a polypeptide comprising a fragment of at least 175 consecutive amino acids of SEQ ID NO:20 that spans the amino acids at positions 219 to 234 of SEQ ID NO:20 and said amino acid sequence has a biological activity selected from the group consisting of regulating cell mobility, regulating cell proliferation, regulating bone remodeling, regulating tissue remodeling and regulating metalloproteinase production; or f) consisting of an amino acid sequence that has at least 90%, 95%, 96%, 97%, 98% or 99% identity to the OAR polypeptide amino acid sequence encoded by the cDNA of deposited clone 158523