Patent ID: 6852685
Filing Date: 2005-02-08
Classification: A61K,C07K

Abstract:
1. A method for promoting cell differentiation, the method comprising contacting pluripotent cells effective to form neuronal cells with a neuronal cell regulator selected from the group consisting of colostrinin, a constituent peptide of colostrinin, an active analog of a constituent peptide of colostrinin, and combinations thereof, under conditions effective to change pluripotent cells in morphology to form neuronal cells; wherein the constituent peptide of colostrinin is selected from the group consisting of MQPPPLP (SEQ ID NO:1), LQTPQPLLQVMMEPQGD (SEQ ID NO:2), DQPPDVEKPDLQPFQVQS (SEQ ID KO:3), LFFFLPVGVLP (SEQ ID NO:4), DLEMPVLPVEPFPFV (SEQ ID NO: 5), MPQNFYKLPQM (SEQ ID NO:6), VLEMKFPPPPQETVT (SEQ ID NO:7), LKPFPCKVEVFPFP (SEQ ID NO:8), VESYVPLFP (SEQ ID NO:31), MHQPPQPLPPTVMFP (SEQ ID NO:34), and combinations thereof; wherein an active analog of a constituent peptide of colostrinin comprises a peptide having an amino acid sequence with at least about 15 percent proline and having at least about 70 percent sequence identity to a constituent peptide of colostrinin selected from the group consisting of MQPPPLP (SEQ ID NO:1), LQTPQPLLQVMMEPQGD (SEQ ID NO:2), DQPPDVEKPDLQPFQVQS (SEQ ID KO:3), LFFFLPVGVLP (SEQ ID NO:4), DLEMPVLPVEPFPFV (SEQ ID NO:5), MPQNFYKLPQM (SEQ ID NO:6), VLEMKFPPPPQETVT (SEQ ID NO:7), LKPFPCKVEVFPFP (SEQ ID NO: 8), VESYVPLFP (SEQ ID NO:31), and MHJQPPQPLPPTVMPP (SEQ ID NO:34); and wherein said pluripotent cells change in morphology to form neuronal cells.