Patent ID: 6262110
Filing Date: 2001-07-17
Classification: A61K,A61P,C07D,C07F

Abstract:
A method for inhibiting farnesyl-protein transferase activity, comprising contacting a cell with an amount of a sesquiterpene lactone effective to inhibit farnesyl-protein transferase activity of said cell, said sesquiterpene lactone having formula A, ##STR9##wherein:C.sub.1 is further bonded to hydrogen, hydroxy, short chain alkanoyloxy, or together with C.sub.2 or C.sub.10 form a double bond or an epoxide;C.sub.2 is further bonded to at least one of hydrogen, hydroxy, oxo, short chain alkanoyloxy, and together with C.sub.1 or C.sub.3 form a double bond or an epoxide;C.sub.3 is further bonded to at least one of hydrogen, oxo, and together with C.sub.2 or C.sub.4 form a double bond or an epoxide;C.sub.4 is further bonded to hydrogen, bydroxy, short chain alkanoyloxy, or together with C.sub.3, C.sub.5, or C.sub.15 form an epoxide or a double bond;C.sub.5 is further bonded to hydrogen, hydroxy, short chain alkanoyloxy, or together with C.sub.4 form an epoxide or a double bond;C.sub.6 is further bonded to hydrogen;C.sub.7 is further bonded to hydrogen or together with C.sub.11 form a double bond;C.sub.8 is further bonded to at least one of hydrogen, hydroxy, and short chain alkanoyloxy;C.sub.9 is further bonded to at least one of hydrogen, and together with C.sub.10 form a double bond;C.sub.10 is further bonded to hydrogen, hydroxy, short chain alkanoyloxy, together with C.sub.1 or C.sub.14 form an epoxide, or together with C.sub.1, C.sub.9, or C.sub.14 form a double bond;C.sub.11 is further bonded to hydrogen, hydroxy, hydroxymethyl, or together with C.sub.7 or C.sub.13 form a double bond;C.sub.13 is further bonded to at least one of hydrogen, an optionally substituted alkylamino salt, and together with C.sub.11 form a double bond;C.sub.14 is further bonded to at least one of hydrogen and together with C.sub.10 form an epoxide or a double bond; andC.sub.15 is further bonded to at least one of hydrogen and together with C.sub.4 form an epoxide or a double bond.