Patent ID: 7217728
Filing Date: 2007-05-15
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula: wherein R 1 is a group of the formula where A is hydrogen, hydroxy, amino, or halogen and B is amino, carboxy, hydrogen, hydroxy, cyano, trifluoromethyl, halogen, lower alkyl, or lower alkoxy; R 2 is a group of the formula where R 3 is hydrogen, carboxy, or lower alkyl; n is 0 or 1; U, V, and W are independently hydrogen, halogen, or lower alkyl provided U and V are not both hydrogen; X is carbonyl, phenyl-substituted loweralkylene, or sulfonyl; Y is lower alkylene which may be substituted with one or more of amino, substituted amino, lower alkyl, or cyclo lower alkyl, or Y is lower alkenylene or lower alkylenethio; and k is 0 or 1; when k is 1: Z is hydrogen, lower alkylthio, —COOH, —CONH or a pharmaceutically acceptable salts and esters thereof.