Patent ID: 6723711
Filing Date: 2004-04-20
Classification: A61P,C07D

Abstract:
A compound of the structure wherein circle Q represents a 2-pyridinone or 2-pyrimidone group; q is an integer of zero to six; M is selected from the group consisting of â€”C(R9)(R10)â€” and â€”(CH2)uâ€”, wherein u is an integer of from 0 to 3; J is selected from the group consisting of â€”Oâ€”, â€”Sâ€” and â€”NR12â€”; T is selected from the group consisting of â€”C(O)â€” and â€”(CH2)bâ€” wherein b is an integer of from 0 to 3; L is selected from the group consisting of â€”Oâ€”, â€”NR13â€”, â€”Sâ€”, and â€”(CH2)vâ€” wherein v is an integer of 0 or 1; X is selected from the group consisting of â€”CO2B, â€”PO3H2, â€”SO3H, â€”SO2NH2, â€”SO2NHCOR14, â€”OPO3H2, â€”C(O)NHC(O)R15, â€”C(O)NHSO2R16, tetrazolyl, oxazolyl and hydroxyl; R11, R12 and R13 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, aliphatic acyl, alkynylamino, alkoxycarbonyl, heterocycloyl, â€”CH&boxH;NOH, haloalkyl, alkoxyalkyl, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, aryl, heterocyclic aromatic, aroyl, aryloxy, arylamino, biaryl, thioaryl, diarylamino, heterocyclyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, carbamate, aryloxyalkyl and â€”C(O)NH(benzyl) groups; B, R1, R6, R8, R9, R10, R14, R15 and R16 at each occurrence are independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, thioalkoxy, hydroxyalkyl, aliphatic acyl, â€”CF3, â€”CO2H, â€”SH, â€”CN, â€”NO2, â€”NH2, â€”OH, alkynylamino, alkoxycarbonyl, heterocycloyl, carboxy, N(C1-C3 alkyl)â€”C(O)C1-C3 alkyl), â€”NHC(O)N(C1-C3 alkyl)C(O)â€”NH(C1-C3 alkyl), â€”NHC(O)NH(C1-C6 alkyl), â€”NHSO2(C1-C3 alkyl), â€”NHSO2(aryl), alkoxyalkyl, alkylamino, alkenylamino, di(C1-C3)amino, â€”C(O)Oâ€”(C1-C3)alkyl, â€”C(O)NHâ€”(C1-C3)alkyl, â€”C(O)N(C1-C3 alkyl)2, â€”CH&boxH;NOH, â€”PO3H2, â€”OPO3H2, haloalkyl, alkoxyalkoxy, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, aryl, heterocyclic aromatic, aroyl, aryloxy, arylamino, biaryl, thioaryl, diarylamino, heterocyclyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, sulfonyl, â€”SO2â€”(C1-C3alkyl), â€”SO3â€”(C1-C3 alkyl), sulfonamido, carbamate, aryloxyalkyl and â€”C(O)NH(benzyl) groups; and R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, thioalkoxy, hydroxyalkyl, aliphatic acyl, â€”CF3, â€”CO2H, â€”SH, â€”CN, â€”NO2, â€”NH2, â€”OH, alkynylamino, alkoxycarbonyl, heterocycloyl, carboxy, â€”N(C1-C3 alkyl)â€”C(O)(C1-C3 alkyl), â€”NHC(O)N(C1-C3 alkyl)C(O)â€”NH(C1-C3 alkyl), â€”NHC(O)NH(C1-C6 alkyl), â€”NHSO2(C1-C3 alkyl), â€”NHSO2(aryl), alkoxyalkyl, alkylamino, alkenylamino, di(C1-C3)amino, â€”C(O)Oâ€”(C1-C3)alkyl, â€”C(O)NHâ€”(C1-C3)alkyl, â€”C(O)N(C1-C3 alkyl)2, â€”CH&boxH;NOH, â€”PO3H2, â€”OPO3H2, alkoxyalkoxy, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, aryl, heterocyclic aromatic, aroyl, aryloxy, arylamino, biaryl, thioaryl, diarylamino, heterocyclyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, sulfonyl, â€”SO2â€”(C1-C3 alkyl), â€”SO3â€”(C1-C3 alkyl), sulfonamido, carbamate, aryloxyalkyl and â€”C(O)NH(benzyl) groups; wherein B, R1, R4, R6, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are unsubs or substituted with at least one electron donating or electron withdrawing group; wherein when L is â€”NR13â€”, R4 and R13 taken together may form a ring; and wherein at least one of R6 and R8 must be other than hydrogen; and wherein when M is â€”C(R9)(R10)â€”, R9 and R10 taken together may form a ring; or a pharmaceutically acceptable salt thereof.