Patent ID: 6448284
Filing Date: 2002-09-10
Classification: A61P,C07D

Abstract:
A compound of the formula (I) wherein;Z is â€ƒâ€”CH2, A is â€”O(CH2)fâ€”, â€”NH(CH2)fâ€”, â€”S(CH2)fâ€”, â€”(CH2)f where f is 1 to 3; â€”CH&boxH;CHâ€”, â€ƒor â€”(La)â€”, wherein â€”(La)â€” is a linker having a linker length of 1 to 7; R1â€² is â€”NHNH2 or â€”NH2; R2â€² is â€”CO2H; â€”CO2(C1-C4)alkyl; â€ƒwhere R6 and R7 are each independently â€”OH or â€”O(C1-C4)alkyl; tetrazolyl; â€”NR9R10 where R9 and R10 are independently hydrogen, â€”CF3, â€”(C1-C4)alkyl, phenyl or â€”(C1-C4)alkylphenyl; â€”SO2R15; CONHSO2R15, where R15 is hydrogen, aryl â€”(C1-C6)alkyl or â€”CF3; or phenyl substituted with â€”CO2H or â€”CO2(C1-C4)alkyl; R3â€² is selected from non-interfering substituents, carbocyclic radicals, carbocyclic radicals substituted with non-interfering substituents, heterocyclic radicals, and heterocyclic radicals substituted with non-interfering substituents; R4â€² is selected from groups (a) and (b) where; (a) is â€”(C5-C20)alkyl, â€”(C5-C20)alkenyl, â€”(C5-C20)alkynyl, carbocyclic radicals, or heterocyclic radicals, or (b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or a pharmaceutically acceptable racemate, solvate, optical isomer, prodrug compound or salt thereof.