Patent ID: 6319910
Filing Date: 2001-11-20
Classification: A61K,A61P,Y02A

Abstract:
A method for treating a disease or disorder associated with an elevated level of TNF.alpha. and/or products of COX-2 activity, comprising administering to a subject in need thereof a chemically modified tetracycline compound having negligible anti-microbial activity in an amount sufficient to reduce the expression or activity of COX-2 and/or TNF.alpha. in the subject to treat a disease or disorder associated with an elevated level of TNF.alpha. and/or products of COX-2 activity selected from the group consisting of multiple sclerosis, septic shock, graft-vs.-host disease, cerebral malaria, cachexia associated with HIV infection, brain ischemia, inflammatory bowel disease, and neurodegenerative disorders.