Patent ID: 7348175
Filing Date: 2008-03-25
Classification: C12M,Y10S

Abstract:
1. A bioreactor for conditioning tissue, comprising: a bioreactor chamber, the bioreactor chamber including at least one clamp for holding the tissue; a dynamic flow pump for providing dynamic nutrient fluid flow across a surface of the tissue; a mean flow pump for providing mean nutrient fluid flow across a surface of the tissue; one or more sensors for measuring real time mechanical response of the tissue to conditioning; and a microprocessor control for providing real time monitoring and control of sample tissue conditioning, including selective real time adjustment or alteration of mechanical conditioning parameters for the tissue within the bioreactor chamber, wherein the microprocessor control is in communication with the one or more sensors and adapted to selectively programmably adjust or alter conditioning parameters based on variations of the mechanical response and sensed conditions of the tissue and bioreactor conditions as measured by the one or more sensors.