Patent ID: 9025150
Filing Date: 2015-05-05
Classification: G01B,G02B

Abstract:
1. An incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample, comprising: a source for emitting an incident wave having a given spectral band; an interference device comprising a reference arm and an object arm, to provide optical interference between a reference wave obtained by reflection of the incident wave on a reflective surface of the reference arm and an object wave obtained by the backscattering of the incident wave by a slice of the sample at a given depth of said sample, when said sample is placed in an object focal plane of a microscope objective placed in the object arm; a device for multichannel acquisition of at least a first interference signal and at least a second interference signal resulting from the optical interference of said reference and object waves, the at least two interference signals having a phase difference produced by varying the relative path length difference between the two arms of the interference device, said device for multichannel acquisition being placed in a plane optically conjugated with said object focal plane of said microscope objective of the object arm; and a processing unit for calculating an image of the slice of the sample based on said first and second interference signals, wherein the interference device additionally comprises an optical element for modifying the phase of the wavefront of one of said reference or object waves, and the microscopy device comprises a control unit for the optical element, linked to the processing unit, the optical phase modification element being controlled by optimizing a statistical parameter of at least a part of the image calculated by the processing unit.