Patent ID: 6803367
Filing Date: 2004-10-12
Classification: A61P,C07C,C07D

Abstract:
A substance for inducing apoptosis represented by the following formula [II]-[VIII] or an optically active substance or a pharmaceutically acceptable salt thereof: where, in formula III R1 is H, an amino group, a lower alkyl group or a lower alkyl group having a substituent in an amino acid; R2 is a divalent residue after removal of carboxyl group and amino group participating in a peptide bond in an amino acid; X is O31  or an amino group; Ykâˆ’ is an anion having valence(s) of k; m is an integer of 0-4; n is 0 or a positive integer; k is a positive integer; and when n is 2 or more, two or more R2 existing therein may be same or different while, when X is Oâˆ’, the substance is an inner salt whereby Ykâˆ’. does not exist; where, in formula VI, R3 and R4 may be same or different and each is an alkyl group having 1-3 carbons; where, in formula VII, R5 and R6 may be same or different and each is an aromatic ring of an aromatic amino acid; or