Patent ID: 7541458
Filing Date: 2009-06-02
Classification: C07D,C07F

Abstract:
1. A process for the preparation of cis-β-lactam (1A), the process comprising treating an imine (2) with a ketene acetal (3A) in the presence of a siloxide, M + O − SiR 51 R 52 R 53 , to form a reaction product mixture comprising cis- and trans-β-lactams (1A) and (1B), with the ratio of cis-β-lactam (1A) to trans-β-lactam (1B) in the reaction product mixture being at least 3:1 (cis:trans), wherein the cis- and trans-β-lactams (1A) and (1B), the imine (2), and the ketene acetal (3A) correspond to Formulae (1A), (1B), (2), and (3A), respectively: M X X X and —SiR