Patent ID: 6531153
Filing Date: 2003-03-11
Classification: A61K,A61P

Abstract:
Pharmaceutical composition comprising a therapeutically effective amount of levodopa and of carbidopa, dispersed in a hydrophilic matrix, said composition further comprising an organic acid, where this acid is selected from the group consisting of fumaric acid, citric acid, ascorbic acid, maleic acid, glutamic acid, malonic acid and oxalic acid and represents from 0.2% to 5% by weight relative to the weight of the composition, and where the hydrophilic matrix represents from 10% to 80% by weight relative to the weight of the composition, said hydrophilic matrix comprising as a percentage by weight relative to the weight of the composition, between 5% and 40% of hydroxypropylmethylcellulose with a viscosity of about 50 cP and between 5% and 40% by weight of hydroxypropylmethylcellulose with a viscosity of about 3 cP.