Patent ID: 6359167
Filing Date: 2002-03-19
Classification: A61L,A61P,C07C

Abstract:
A compound containing at least one stabilized S-nitrosyl group and at least one free thiol group or free alcohol group, wherein the S-nitrosyl group is stabilized by the free alcohol group or the free thiol group and wherein the compound has a half-life for NO-release that is at least two times as great as the corresponding compound without the free thiol group or free alcohol group, with the proviso that the compound is not a polypeptide, and unsubstituted S-nitrosylated straight chained or branched alkane dithiol, an unsubstituted S-nitrosylated straight chained or branched monothiolated alkanol, an S-nitrosylated polysaccharide or a polymer with pendant S-nitrosyl groups and is not an S-nitrosylated derivative of a compound represented by one of the following structural formulas: wherein each Ra is â€”H or methyl and is independently chosen.