Patent ID: 6720315
Filing Date: 2004-04-13
Classification: A61P,C07D

Abstract:
A compound of the Formula: or a pharmaceutically acceptable salt thereof, wherein â€ƒis a phenyl ring, optionally substituted with one or more substituent selected from the group consisting of alkyl, haloalkyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, halogen, alkoxyalkyl, aminoalkyl, hydroxy, nitro, alkoxy, hydroxyalkyl, thioalkyl, amino, alkylamino, arylamino, alkylsulfonamide, â€ƒwherein R26 is selected from alkyl, alkenyl, alkynyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, and aralkyl; acylamino, sulfone, sulfonamide, alkenyl, methylenedioxy, ethylenedioxy, alkynyl, carboxamide, cyano, and â€”(CH2)nCOR wherein n is 0-2 and R is selected from the group consisting of hydroxy, alkoxy, alkyl and amino; A1 is a pyridine, optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino, alkylamino, halogen, acylamino, sulfonamide and â€”COR wherein R is selected from hydroxy, alkoxy, alkyl and amino; Z1 is selected from the group consisting of CH2, CH2CO, S, SO, CH(OH) and SO2; Z2 is a 1-5 carbon linker optionally containing one or more heteroatom selected from the group consisting of O, S and N; wherein the carbon and nitrogen atoms of Z1-Z2 are optionally substituted by a moiety selected from the group consisting of alkyl, alkoxy, thioalkyl, alkylsulfone, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, alkoxyalkyl, alkylamino, heteroaryl, alkenyl, alkynyl, carboxyalkyl, halogen, haloalky and acylamino;n is an integer 0, 1 or 2; Rc is selected from the group consisting of hydrogen; alkyl; halogen, hydroxy, nitro, alkoxy, amino, haloalkyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, alkoxyalkyl, aminoalkyl, hydroxyalkyl, thioalkyl, alkylamino, arylamino, alkylsulfonylamino, â€ƒwherein R26 is selected from alkyl, alkenyl, alkynyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, and aralkyl, acylamino, sulfonyl, sulfonamide, alkenyl, methylenedioxy, ethylenedioxy, alkynyl, alkynylalkyl, carboxy, alkoxycarbonyl, carboxamido, cyano, and â€”(CH2)nCOR wherein n is 0-2 and R is selected from hydroxy, alkoxy, alkyl and amino; X is selected from the group consisting of â€”CHReâ€”, â€”NRfâ€”, â€”Oâ€”, â€”Sâ€”, â€”SO2â€”, and CO wherein Re is selected from H, lower alkyl, alkoxy, cycloalkyl, alkoxyalkyl, hydroxy, alkynyl, alkenyl, haloalkyl, thioalkyl, phenyl, pyridyl, naphthyl, thiophene, furan, and biphenyl; wherein when Re is hydroxy the hydroxy optionally forms a lactone with the carboxylic acid function of the chain; wherein Rf is selected from the group consisting of H, alkyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, benzyl and haloalkyl; Y is selected from the group consisting of â€”CRgâ€” and â€”Ngâ€”wherein Rg is selected from the group consisting of H, alkyl, haloalkyl, alkoxyalkyl, alkynyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, piperidine, aralkyl, hydroxy, alkoxy, and carboxyalkyl; Rb is X2â€”Rh wherein X2 is selected from the group consisting of O, S and NRj wherein Rh and Rj are independently selected from the group consisting of H, alkyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, aralkyl, alkoxyalkyl, and â€ƒwherein R26 is selected from alkyl, alkenyl, alkynyl, phenyl, pyridyl, naphthyl, thiophene, furan, biphenyl, and aralkyl alkoxyalkyl; and Ra is selected from the group consisting of hydrogen, alkyl, alkenyl, alkoxyalkyl, hydroxyalkyl, alkynyl, alkynylalkyl, alkenylalkyl, haloalkyl, phenyl, benzofuran, benzothiophene, indole, quinoline, isoquinoline, benzimidazole, benzoxazole, 1,3-benzodioxole, 1,4-benzodioxane, benzopyran, quinolone, imidazopyridine, tetrahydroquinoline, benzotriazole, dihydroindole, dihydrobenzofuran, furan, thiophene, phenyl, oxazole, thiazole, isoxazole, pyrazole, imidazole, pyrrole, pyridine, pyrimidine, pyridone, triazole, thiadiazole all optionally substituted at one or more position with a substituent selected from the group consisting of alkyl, alkoxy, hydroxy, cyano, halogen, and haloalkyl; aralkyl, heteroaralkyl, cycloalkyl, carboxyl, amino, alkylamine, alkoxycarbonyl, carboxamido, hydroxy, cyano, alkoxy, thioalkyl, acylamino, sulfonyl amino, alkylsulfonyl, and â€”(CH2)nCORb wherein n is 0-2 and Rb is as defined above.