Patent ID: 7148346
Filing Date: 2006-12-12
Classification: A61K,C07D,C07K

Abstract:
1. A process for purifying on a large scale a product from a feedstock containing one or more impurities having closely-related physical properties to the product, which process compromises: feeding the feedstock into an extraction column under conditions adapted for separating more-or-less polar impurities from the feedstock, wherein a lighter phase flows counter to a heavier phase, thereby forming an output in one phase containing the product containing less more- or less-polar impurities so that the output contains the product in a substantially purified form, wherein the lighter phase compromises heptane and acetone or heptane and isopropanol, the heavier phase compromises water and acetone or water and isopropanol, and the product is rapamycin or 40-O-(2-hydroxy)ethyl rapamycin or ascomycin or a derivative thereof selected from the group consisting of 33-epi-chloro-33-desoxyascomycin, 5,6-dehydro-ascomycin or FK506.