Patent ID: 6358930
Filing Date: 2002-03-19
Classification: A61K,A61P

Abstract:
A method to treat or prevent Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC), diarrhea or another condition mediated by C. difficile toxin B in a subject, which method comprises administering to a subject in need of such treatment or prevention a composition comprising at least one toxin B binding oligosaccharide sequence covalently attached to a pharmaceutically acceptable inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds toxin B, and wherein said composition is capable of being eliminated from the gastrointestinal tract wherein said oligosaccharide sequence is selected from the group consisting of: &agr;Glc(1-2)&bgr;Gal, &agr;Glc(1-4)&bgr;Glc, &bgr;Glc(1-4)&bgr;Glc, &agr;Glc(1-6)&agr;Glc(1-6)&bgr;Glc, &agr;Glc(1-6)&bgr;Glc, and &bgr;GlcNAc(1-4)&bgr;GlcNAc.