Patent ID: 6020369
Filing Date: 2000-02-01
Classification: A61K

Abstract:
A method for preventing respiratory viral infection, comprising administering to a subject at risk an effective amount of a polyoxometalate selected from the group consisting of[(NMP).sub.2 H].sub.3 PW.sub.12 O.sub.40[(DMA).sub.2 H].sub.3 PMo.sub.12 O.sub.40(NH.sub.4).sub.17 Na[NaSb.sub.9 W.sub.21 O.sub.86 ]a- and b-H.sub.5 BW.sub.12 O.sub.40a- and b-H.sub.6 ZnW.sub.12 O.sub.40a- and b-H.sub.6 P.sub.2 W.sub.18 O.sub.62.alpha.-(NH.sub.4).sub.6 P.sub.2 W.sub.18 O.sub.62K.sub.10 Cu.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.20H.sub.2 OK.sub.10 Co.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.20H.sub.2 ONa.sub.7 PW.sub.11 O.sub.39Na.sub.7 PW.sub.11 O.sub.39.20H.sub.2 O+2C.sub.6 H.sub.5 P(O)(OH).sub.2(n-Bu.sub.4 N).sub.4 H.sub.3 PW.sub.11 O.sub.39b-Na.sub.8 HPW.sub.9 O.sub.34(n-Bu.sub.4 N).sub.3 PMoW.sub.11 O.sub.39a-[(nBu).sub.4 N].sub.4 Mo.sub.8 O.sub.26(n-Bu.sub.4 N).sub.2 W.sub.6 O.sub.19(n-Bu.sub.4 N).sub.2 Mo.sub.6 O.sub.19a-(NH.sub.4).sub.n H.sub.(4-n) SiW.sub.12 O.sub.40a-(NH.sub.4).sub.n H.sub.(5-n) BW.sub.12 O.sub.40a-K.sub.5 BW.sub.12 O.sub.40K.sub.4 W.sub.4 O.sub.10 (O.sub.2)6b-Na.sub.9 HSiW.sub.9 O.sub.34Na.sub.6 H.sub.2 W.sub.12 O.sub.40(NH.sub.4).sub.14 [NaP.sub.5 W.sub.30 O.sub.110 ]a-(NH.sub.4).sub.5 BW.sub.12 O.sub.40a-Na.sub.5 BW.sub.12 O.sub.40(NH.sub.4).sub.4 W.sub.10 O.sub.32(Me.sub.4 N).sub.4 W.sub.10 O.sub.32(NISH.sup.+).sub.n H.sub.(5-n) BW.sub.12 O.sub.40(LYSH.sup.+).sub.n H.sub.(5-n) BW.sub.12 O40(ARGH.sup.+).sub.n H.sub.(5-n) BW.sub.12 O.sub.40(HISH.sup.+).sub.n H.sub.(4-n) SiW.sub.12 O.sub.40(LYSH.sup.+).sub.n H.sub.(4-n) SiW.sub.12 O.sub.40(ARGH.sup.+).sub.n H.sub.(4-n) SiW.sub.12 O.sub.40a-K.sub.8 SiW.sub.11 O.sub.39a-K.sub.8 SiW.sub.11 O.sub.39K.sub.10 (H.sub.2 W.sub.12 O.sub.42)K.sub.12 Ni.sub.3 (II)(PW.sub.9 O.sub.34).sub.2.nH.sub.2 O(NH.sub.4).sub.10 Co.sub.4 (II)(PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.12 Pd.sub.3 (II)(PW.sub.9 O.sub.34).sub.2.nH.sub.2 ONa.sub.12 P.sub.2 W.sub.15 O.sub.56.18H.sub.2 ONa.sub.16 Cu.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).sub.2.nH.sub.2 ONa.sub.16 Zn.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).sub.2.nH.sub.2 ONa.sub.16 Co.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).sub.2.nH.sub.2 ONa.sub.16 Ni.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).sub.2.nH.sub.2 ONa.sub.16 Mn.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).nH.sub.2 ONa.sub.16 Fe.sub.4 (H.sub.2 O).sub.2 (P.sub.2 W.sub.15 O.sub.56).sub.2.nH.sub.2 OK.sub.10 Zn.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.20H.sub.2 OK.sub.10 Ni.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.10 Mn.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.10 Fe.sub.4 (H.sub.2 O).sub.2 (PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.12 Cu.sub.3 (PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.12 (Co H.sub.2 O).sub.3 (PW.sub.9 O.sub.34).sub.2.nH.sub.2 OK.sub.12 Zn.sub.3 (PW.sub.9 O.sub.34).sub.2.15H.sub.2 OK.sub.12 Mn.sub.3 (PW.sub.9 O.sub.34).sub.2.15H.sub.2 OK.sub.12 Fe.sub.3 (PW.sub.9 O.sub.34).sub.2.25H.sub.2 O(ARGH.sup.+).sub.10 (NH.sub.4).sub.7 Na[NaSb.sub.9 W.sub.21 O.sub.86 ](ARGH.sup.+).sub.5 HW.sub.11 O.sub.39.17H.sub.2 OK.sub.7 Ti.sub.2 W.sub.10 O.sub.40[(CH.sub.3).sub.4 N].sub.7 Ti.sub.2 W.sub.10 O.sub.40Cs.sub.7 Ti.sub.2 W.sub.10 O.sub.40[HISH+].sub.7 Ti.sub.2 W.sub.10 O.sub.40(LYSH+).sub.n Na.sub.7-n PTi.sub.2 W.sub.10 O.sub.40(ARGH+).sub.n Na.sub.7-n PTi.sub.2 W.sub.10 O.sub.40Cs.sub.4 [SiW.sub.11 O.sub.39.O(SiCH.sub.2 CH.sub.2 C(O)OCH.sub.3).sub.2 ].sub.4 --[TBA].sub.3 H.sub.3 V.sub.10 O.sub.28K.sub.7 HNb.sub.6 O.sub.19.13H.sub.2 OK.sub.8 Ta.sub.6 O.sub.19.17H.sub.2 O[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 --O(SiCH.sub.2 CH.sub.2 C(O)OCH.sub.3).sub.2[CH.sub.3).sub.4 N.sup.+ ].sub.4 PW.sub.11 O.sub.39 --(SiCH.sub.2 CH.sub.2 CH.sub.2 CN)[(CH.sub.3).sub.4 N.sup.+ ].sub.4 PW.sub.11 O.sub.39 --(SiCH.sub.2 CH.sub.2 CH.sub.2 Cl)[(CH.sub.3).sub.4 N.sup.+ ].sub.4 PW.sub.11 O.sub.39 --(SiCH.dbd.CH.sub.2)Cs.sub.4 [SiW.sub.11 O.sub.39 --(SiCH.sub.2 CH.sub.2 CH.sub.2 CN).sub.2 ]Cs.sub.4 [SiW.sub.11 O.sub.39 --(SiCH.sub.2 CH.sub.2 CH.sub.2 Cl).sub.2 ]Cs.sub.4 [SiW.sub.11 O.sub.39 --(SiCH.dbd.CH.sub.2).sub.2 ][(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 O(SiCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3).sub.2[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 --O.sub.39 O(SiCH.sub.2 CH.sub.2 CH.sub.2 Cl).sub.2[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 --O(SiCH.sub.2 CH.sub.2 CH.sub.2 CN).sub.2[(CH.sub.3).sub.4 N.sup.+ ]SiW.sub.11 O.sub.39 --O(SiCH.dbd.CH.sub.2).sub.2[(CH.sub.2).sub.4 N.sup.+ ]SiW.sub.11 O.sub.39 --O(SiC(CH.sub.3).sub.3).sub.2[(CH.sub.3).sub.4 N.sup.+ ]SiW.sub.11 O.sub.39 --O(SiCH.sub.2 CH(CH.sub.3).sub.2).sub.2[(CH.sub.3).sub.4 N.sup.+ ].sub.3 PW.sub.11 O.sub.39 O(SiCH.sub.2 CH.sub.2 COOCH.sub.3).sub.2K.sub.5 Mn(II)PW.sub.11 O.sub.39 --nH.sub.2 OK.sub.8 Mn(II)P.sub.2 W.sub.17 O.sub.61.nH.sub.2 OK.sub.6 Mn(II)SiW.sub.11 O.sub.39.nH.sub.2 OK.sub.5 PW.sub.11 O.sub.39 (SiMe.sub.2).nH.sub.2 OK.sub.3 PW.sub.11 O.sub.41 (PPh).sub.2.xH.sub.2 ONa.sub.3 PW.sub.11 O.sub.41 (PPh).sub.2.xH.sub.2 OK.sub.5 PTiW.sub.11 O.sub.40Cs.sub.5 PTiW.sub.11 O.sub.39K.sub.6 SiW.sub.11 O.sub.39 (SiMe.sub.2).nH.sub.2 OK.sub.3 PW.sub.11 O.sub.41 (PEt).sub.2.nH.sub.2 OKSiW.sub.11 O.sub.39 [SiPh(t-Bu)].nH.sub.2 OK.sub.6 SiW.sub.11 O.sub.39 (SiPh.sub.2).nH.sub.2 OK.sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 OCs.sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 OCs.sub.8 Si.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 O(Me.sub.3 NH).sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 O(CH.sub.3 H.sub.6).sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 O(CN.sub.3 H.sub.6).sub.8 Si.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 ORb.sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 ORb.sub.8 Si.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 OK.sub.8 Si.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 OK.sub.6 P.sub.2 Mo.sub.18 O.sub.62.nH.sub.2 O(C.sub.5 H.sub.5 N).sub.7 HSi.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 O(C.sub.5 H.sub.5 N).sub.7 SiW.sub.9 Nb.sub.3 O.sub.40.nH.sub.2 O(ARGH.sup.+).sub.8 SiW.sub.18 Nb.sub.6 O.sub.77.18H.sub.2 O(LYSH.sup.+).sub.7 K SiW.sub.18 Nb.sub.6 O.sub.77.18H.sub.2 O(HISH.sup.+).sub.6 K.sub.2 SiW.sub.18 Nb.sub.6 O.sub.77.18H.sub.2 OH.sub.8 Si.sub.2 W.sub.18 Nb.sub.6 O.sub.77.nH.sub.2 O (2 batches)[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 --O(SiCH.sub.2 CH.sub.3).sub.2[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 --O(SiCH.sub.3).sub.2[(CH.sub.3).sub.4 N.sup.+ ].sub.4 SiW.sub.11 O.sub.39 --O(SiC.sub.16 H.sub.33).sub.2Li.sub.7 HSi.sub.2 W.sub.18 Nb.sub.6 O.sub.77Li.sub.9 P.sub.2 V.sub.3 Me.sub.3 W.sub.12 O.sub.62Cs.sub.9 P.sub.2 V.sub.3 MeW.sub.12 O.sub.62Cs.sub.12 P.sub.2 V.sub.3 W.sub.12 O.sub.62K.sub.4 H.sub.2 PV.sub.4 W.sub.8 O.sub.40Na.sub.12 P.sub.4 W.sub.14 O.sub.58Na.sub.14 H.sub.6 P.sub.6 W.sub.18 O.sub.79a-K.sub.5 (NbO.sub.2)SiW.sub.11 O.sub.39K.sub.5 (TaO.sub.2)SiW.sub.11 O.sub.39(Me.sub.3 NH).sub.5 (NbO.sub.2)SiW.sub.11 O.sub.39(Me.sub.3 NH).sub.5 NbSiW.sub.11 O.sub.40(Me.sub.3 NH).sub.5 (TaO.sub.2)SiW.sub.11 O.sub.39K.sub.4 (NbO.sub.2)PW.sub.11 O.sub.39K.sub.7 (NbO.sub.2)P.sub.2 W.sub.12 O.sub.61(Me.sub.3 NH).sub.7 (NbO.sub.2).sub.3 SiW.sub.9 O.sub.37Cs.sub.7 (NbO.sub.2).sub.3 SiW.sub.9 O.sub.37K.sub.6 (NbO.sub.2).sub.3 PW.sub.9 O.sub.37Na.sub.10 (H.sub.2 W.sub.12 O.sub.42)K.sub.4 NbPW.sub.11 O.sub.40(Me.sub.3 NH).sub.4 NbPW.sub.11 O.sub.40K.sub.5 NbSiW.sub.11 O.sub.40K.sub.5 TaSiW.sub.11 O.sub.40(Me.sub.3 NH).sub.5 TaSiW.sub.11 O.sub.40K.sub.6 Nb.sub.3 PW.sub.9 O.sub.40K.sub.7 NbP.sub.2 W.sub.17 O.sub.62K.sub.7 (TiO.sub.2).sub.2 PW.sub.10 O.sub.38K.sub.7 (TaO.sub.2).sub.3 SiW.sub.9 O.sub.37K.sub.7 Ta.sub.3 SiW.sub.9 O.sub.40K.sub.6 (TaO.sub.2).sub.3 PW.sub.9 O.sub.37K.sub.6 Ta.sub.3 PW.sub.9 O.sub.40K.sub.8 Co.sub.2 W.sub.11 O.sub.39H.sub.2 (Me.sub.4 N).sub.4 (EtSi).sub.2 CoW.sub.11 O.sub.40H.sub.2 (Me.sub.4 N).sub.4 (iso-C.sub.4 H.sub.9 Si).sub.2 CoW.sub.11 O.sub.40K.sub.9 (NbO.sub.2).sub.3 P.sub.2 W.sub.15 O.sub.59K.sub.9 Nb.sub.3 P.sub.2 W.sub.15 O.sub.62K.sub.12 (NbO.sub.2).sub.6 P.sub.2 W.sub.12 O.sub.56K.sub.12 Nb.sub.6 P.sub.2 W.sub.12 O.sub.61a.sub.2 -K.sub.10 P.sub.2 W.sub.17 O.sub.61K.sub.6 Fe(III)Nb.sub.3 P.sub.2 W.sub.15 O.sub.62K.sub.7 Zn(II)Nb.sub.3 P.sub.2 W.sub.15 O.sub.62(NH.sub.4).sub.6 [a-P.sub.2 W.sub.18 O.sub.62 ].nH.sub.2 OK.sub.12 [H.sub.2 P.sub.2 W.sub.12 O.sub.48 ].24H.sub.2 OK.sub.12 [H.sub.2 P.sub.2 W.sub.12 O.sub.48 ].24H.sub.2 OK.sub.2 Na.sub.1.5 H.sub.4.5 [PtMo.sub.6 O.sub.24 ].8H.sub.2 OK.sub.6 [a.sub.2 -P.sub.2 W.sub.17 MoO.sub.62 ].nH.sub.2 OKHP.sub.2 V.sub.3 W.sub.15 O.sub.62.34H.sub.2 OK.sub.6 [P.sub.2 W.sub.12 Nb.sub.6 O.sub.62 ].24H.sub.2 ONa.sub.6 [V.sub.10 O.sub.28 ].18H.sub.2 O(Guanidinium).sub.8 H[PV.sub.14 O.sub.62 ].3H.sub.2 OK.sub.8 H[PV.sub.14 O.sub.62 ]Na.sub.7 [MnV.sub.13 O.sub.38 ].18H.sub.2 OK.sub.6 [BW.sub.11 O.sub.39 Ga(OH.sub.2)].13H.sub.2 OK.sub.7 H[Nb.sub.6 O.sub.19 ].13H.sub.2 OK.sub.7 H[Nb.sub.6 O.sub.19 ].13H.sub.2 O[MeN/Na/K].sub.4 [Nb.sub.2 W.sub.4 O.sub.19 ][Me.sub.4 N].sub.9 [P.sub.2 W.sub.15 Nb.sub.3 P.sub.62 ][Me.sub.4 N].sub.15 [HP.sub.4 W.sub.30 Nb.sub.6 O.sub.123 ].16H.sub.2 O[Me.sub.4 N].sub.15 [HP.sub.4 W.sub.30 Nb.sub.6 O.sub.123 ].16H.sub.2 O[Na/K].sub.6 Nb.sub.4 W.sub.2 O.sub.19 ][Me.sub.4 N/Na/K].sub.5 [Nb.sub.3 W.sub.3 O.sub.19 ].6H.sub.2 O[Me.sub.4 N/Na/K].sub.5 [Nb.sub.3 W.sub.3 O.sub.19 ].6H.sub.2 O[Me.sub.5 CpRh).sub.4 V.sub.6 O.sub.19 ]K.sub.5 [CpTiSiW.sub.11 O.sub.39 ].12H.sub.2 Ob.sub.2 -K.sub.8 [SiW.sub.11 O.sub.39 ].14H.sub.2 Oa-K.sub.8 [SiW.sub.10 O.sub.36 ].12H.sub.2 OCs.sub.7 Na.sub.2 [PW.sub.10 O.sub.37 ].8H.sub.2 OCs.sub.6 [P.sub.2 W.sub.5 O.sub.23 ].7(1/2)H.sub.2 Og-Cs.sub.7 [PW.sub.10 O.sub.36 ].7H.sub.2 OK.sub.5 [SiNbW.sub.11 O.sub.40 ].7H.sub.2 OK.sub.4 [PNbW.sub.11 O.sub.40 ].12H.sub.2 ONa.sub.6 [Nb.sub.4 W.sub.2 O.sub.19 ].13H.sub.2 ONa.sub.6 [Nb.sub.4 W.sub.2 O.sub.19 ].20H.sub.2 OK.sub.6 [Nb.sub.4 W.sub.2 O.sub.19 ].7H.sub.2 OK.sub.4 [V.sub.2 W.sub.4 O.sub.19 ].3.5H.sub.2 ONa.sub.5 [V.sub.3 W.sub.3 O.sub.19 ].12H.sub.2 OK.sub.6 [PV.sub.3 W.sub.9 O.sub.40 ].14H.sub.2 ONa.sub.9 [A-b-GeW.sub.9 O.sub.34 ].8H.sub.2 ONa.sub.10 [A-a-GeW.sub.9 O.sub.34 ].9H.sub.2 OK.sub.7 [BV.sub.2 W.sub.10 O.sub.40 ].6H.sub.2 ONa.sub.5 [CH.sub.3 Sn(Nb.sub.6 O.sub.19)].10H.sub.2 ONa.sub.5 [CH.sub.3 Sn(Nb.sub.6 O.sub.19)].10H.sub.2 ONa.sub.8 [Pt(P(m-SO.sub.3 Ph).sub.3).sub.3 Cl].3H.sub.2 ONa.sub.3 [P(m-SO.sub.3 Ph).sub.3 ].H.sub.2 O(Me.sub.3 NH).sub.10 (H)[Si.sub.2 (ZrOH).sub.3 W.sub.18 O.sub.68 ].10H.sub.2 O(Me.sub.3 NH).sub.10 (H)[Si.sub.2 (ZrOH).sub.3 W.sub.18 O.sub.68 ].10H.sub.2 OK.sub.7 [A-a-GeNb.sub.3 W.sub.9 O.sub.40 ].18H.sub.2 OK.sub.7 [A-b-SiNb.sub.3 W.sub.9 O.sub.40 ].20H.sub.2 O(Me.sub.3 NH).sub.9 [A-a-HSi.sub.2 Nb.sub.6 W.sub.18 O.sub.78 ](Me.sub.3 NH).sub.9 [A-a-HGe.sub.2 Nb.sub.6 W.sub.18 O.sub.78 ](Me.sub.3 NH).sub.9 [A-a-HGe.sub.2 Nb.sub.6 W.sub.18 O.sub.78 ]K.sub.7 (H)[A-a-Ge.sub.2 Nb.sub.6 W.sub.18 O.sub.77 ].18H.sub.2 OK.sub.8 [A-b-Si.sub.2 Nb.sub.6 W.sub.18 O.sub.77 ] and(Me.sub.3 NH).sub.8 [A-b-Si.sub.2 Nb.sub.6 W.sub.18 O.sub.77 ].