Patent ID: 8153643
Filing Date: 2012-04-10
Classification: A61P,C07D

Abstract:
1. A quinazoline derivative of the Formula I wherein X p is 0, 1, 2 or 3; each R or from a group of the formula: and wherein any aryl, (3-8C)cycloalkyl, (3-8C)cycloalkenyl, heteroaryl or heterocyclyl group within a R or from a group of the formula: or from a group of the formula: and wherein any aryl, heteroaryl or heterocyclyl group within a substituent on R and wherein any heterocyclyl group within a R and wherein any CH, CH q is 0, 1 or 2; each R R R or R R Ring A is pyrazolyl; r is 0, 1, 2 or 3; and each R or from a group of the formula: or two R and wherein any aryl, (3-8C)cycloalkyl, (3-8C)cycloalkenyl, heteroaryl or heterocyclyl group within an R or from a group of the formula: and wherein any aryl, heteroaryl or heterocyclyl group within an R and wherein any heterocyclyl group within an R and wherein any CH, CH and wherein adjacent carbon atoms in any (2-6C)alkylene chain within an R or a pharmaceutically-acceptable salt, or a pharmaceutically-acceptable in vivo cleavable ester, in vivo cleavable ether or in vivo cleavable amide thereof.