Patent ID: 6737409
Filing Date: 2004-05-18
Classification: A61K,A61P,C07K

Abstract:
A compound of the formula, whereinR1, R2 and R3 are each independently hydrogen or (C1-C4)-alkyl; R4 is hydrogen; alkyl optionally substituted with one to three substituents selected from the group consisting of hydroxy, alkoxy, amino, mono- or di-alkylamino, carboxy alkoxycarbonyl, carbamoyl, alkylcarbonyloxy, carbamoyloxy and halogen; alkenyl; alkynyl; (C3-C7)-cycloalkyl; aryl optionally substituted with one to three substituents selected from the group consisting of halogen, alkoxycarbonyl, carbamoyl, sulfamoyl, alkylcarbonyloxy, cyano, mono- or di-alkylamino, alkyl, alkoxy, phenyl, phenoxy, trifluoromethyl, trifluoromethoxy, alkylthio, hydroxy, alkylcarbonylamino, heterocyclyl, 1,3-dioxolyl, 1,4-dioxolyl, amino and benzyl; aralkyl with the aryl group optionally substituted with one to three substituents selected from the group consisting of halogen, alkoxycarbonyl, sulfamoyl, alkylcarbonyloxy, cyano, mono- or di-alkylamino, alkyl, alkoxy, phenyl, phenoxy, trifluoromethyl, trifluoromethoxy, alkylthio, hydroxy, alkylcarbonylamino, heterocyclyl, 1,3-dioxolyl, 1,4-dioxolyl, amino and benzyl; or heterocyclylalkyl; R5 is (C1-C6)-alkylamino; hydroxy; (C3-C7)-cycloalkylamino optionally substituted by phenyl or benzyl; arylamino; aralkylamino having (C1-C4)-alkylene and the aryl group optionally substituted with one to three substituents selected from the group consisting of halogen, alkoxycarbonyl, sulfamoyl, alkylcarbonyloxy, carbamoyloxy, cyano, mono- or di-alkylamino, alkyl, alkoxy, phenyl, phenoxy, trifluoromethyl, trifluoromethoxy, alkylthio, hydroxy, alkylcarbonylamino, heterocyclyl, 1,3-dioxolyl, 1,4-dioxolyl, amino and benzyl; (C1-C4)-alkoxy; benzylhydrazino; heterocyclyl optionally substituted with one to three substituents selected from the group consisting of benzyl, benzhydryl, alkyl, hydroxy, alkoxy, alkylcarbamoyloxy, amino, mono- or di-alkylamino, acylamino, alkoxycarbonylamino, phenyl and halogen; heterocyclylamino; heterocycloalkylamino with the heterocyclyl group optionally substituted with one to three substituents selected from the group consisting of benzyl, benzhydryl, alkyl, hydroxy, alkoxy, alkylcarbamoyloxy, amino, dialkylamino, acylamino, alkoxycarbonylamino and halogen; and aralkyloxy and aralkyl both optionally substituted with one to three substituents from the group consisting of halogen, alkoxycarbonyl, sulfamoyl, alkylcarbonyloxy, cyano, mono- or di-alkylamino, alkyl, alkoxy, phenyl, phenoxy, trifluoromethyl, trifluoromethoxy, alkylthio, hydroxy, alkylcarbonylamino, heterocyclyl, 1,3-dioxolyl, 1,4-dioxolyl, amino, aminosulfonyl and benzyl; and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.