Patent ID: 8778944
Filing Date: 2014-07-15
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I): wherein R R R Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted; wherein the substituents for R Substituent Group A: (1) a halogen atom; (2) a nitro group; (3) a cyano group; (4) a carboxy group that can be esterified; (5) an alkyl group which can be substituted; (6) an alkenyl group which can be substituted; (7) an alkynyl group which can be substituted; (8) a C (9) a C (10) a C (11) a C (12) a heterocyclic group which can be substituted; (13) a hydroxy group; (14) an alkoxy group which can be substituted; (15) a C (16) a C (17) a C (18) an alkyl-carbonyloxy group which can be substituted; (19) an alkoxy-carbonyloxy group which can be substituted; (20) a mono-alkyl-carbamoyloxy group which can be substituted; (21) a di-alkyl-carbamoyloxy group which can be substituted; (22) a C (23) a mono- or di-C (24) a heterocyclic-oxy group which can be substituted; (25) a C (26) a mercapto group; (27) an alkylsulfanyl group which can be substituted; (28) a C (29) a C (30) a C (31) a heterocyclic-sulfanyl group which can be substituted; (32) a formyl group; (33) an alkyl-carbonyl group which can be substituted; (34) a C (35) a C (36) a C (37) a heterocyclic-carbonyl group which can be substituted; (38) an alkylsulfonyl group which can be substituted; (39) a C (40) a C (41) a heterocyclic-sulfonyl group which can be substituted; (42) an alkylsulfinyl group which can be substituted; (43) a C (44) a C (45) a heterocyclic-sulfinyl group which can be substituted; (46) a sulfo group; (47) a sulfamoyl group; (48) a sulfinamoyl group; (49) a sulfenamoyl group; (50) a thiocarbamoyl group: (51) a carbamoyl group which can be substituted; and (52) (i) amino, (ii) mono- or di-alkylamino group which can be substituted, (iii) mono- or di-C wherein, in the Substituent Group A, the “alkoxy-carbonyl group which can be substituted”, the “alkyl group which can be substituted”, the “alkenyl group which can be substituted”, the “alkynyl group which can be substituted”, the “alkoxy group which can be substituted”, the “alkyl-carbonyloxy group which can be substituted”, the “alkoxy-carbonyloxy group which can be substituted”, the “mono-alkyl-carbamoyloxy group which can be substituted”, the “dialkyl-carbamoyloxy group which can be substituted”, the “alkylsulfanyl group which can be substituted”, the “alkylcarbonyl group which can be substituted”, the “alkylsulfonyl group which can be substituted”, the “alkylsulfinyl group which can be substituted”, the “alkyl-carbamoyl group which can be substituted”, the “mono- or di-alkylamino group which can be substituted”, the “alkyl-carbonylamino group which can be substituted”, the “mono-(C the “alkoxy-carbonylamino group which can be substituted”, and the “alkylsulfonylamino group which can be substituted”, substituents are selected from the group consisting of the following substituents as Substituent Group B: wherein, in the Substituent Group A, the “C the “C the “C the “C the “C the “C the “C the “heterocyclic group which can be substituted”, the “C the “C the “C the “C the “mono- or di-C the “heterocyclic-oxy which can be substituted”, the “aromatic heterocyclic-oxy which can be substituted”, the “C the “C the “C the “heterocyclic-sulfanyl which can be substituted”, the “C the “C the “C the “heterocyclic-carbonyl which can be substituted”, the “C the “C the “heterocyclic-sulfonyl which can be substituted”, the “C the “C the “heterocyclic-sulfinyl which can be substituted”, the “carbamoyl group which can be substituted”, the “amino group which can be substituted”, the “mono- or di-C the “mono- or di-C the “mono- or di-C the “heterocyclic amino group which can be substituted”, the “C the “C the “heterocyclic-carbonylamino group which can be substituted”, the “C the “heterocyclic-oxycarbonylamino group which can be substituted”, the “carbamoylamino group which can be substituted”, the “alkylsulfonylamino group which can be substituted”, the “C the “heterocyclic sulfonylamino group which can be substituted”, and the “C substituents are selected from the group consisting of (1) the substituents of the Substituent Group B and (2) substituents selected from the group consisting of the following Substituent Group B′: provided that the following compounds: 1-(2-chlorophenyl)-6-methyl-3-{5-thioxo-4-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-1,2,4-triazol-3-yl}pyridazin-4(1H)-one, 1-(4-chlorophenyl)-3-[4-(2-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]-6-methylpyridazin-4(1H)-one, 1-(4-chlorophenyl)-6-methyl-3-{5-thioxo-4-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-1,2,4-triazol-3-yl}pyridazin-4(1H)-one, 1-(4-chlorophenyl)-3-[4-(2-fluorophenyl)-5-(methylsulfanyl)-4H-1,2,4-triazol-3-yl]-6-methylpyridazin-4(1H)-one, 1-(4-chlorophenyl)-6-methyl-3-{5-(methylsulfanyl)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}pyridazin-4(1H)-one, 1-(2-chlorophenyl)-6-methyl-3-{5-(methylsulfanyl)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}pyridazin-4(1H)-one, 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylpyridazin-4(1H)-one, 1-(4-chlorophenyl)-3-{(1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}pyridazin-4(1H)-one, 3-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-[1-(3-chlorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-[1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-[1-(3-nitrophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-[1-(1,1-dioxidotetrahydrothiophen-3-yl)-H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, 3-[1-(4-methylphenyl)-H-pyrazol-5-yl]-1-phenylpyridazin-4(1H)-one, 3-[1-(4-chlorophenyl)-H-pyrazol-5-yl]-1-phenylpyridazin-4(1H)-one, 3-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-(4-methylphenyl)pyridazin-4(1H)-one, a compound of formula: wherein Ring A′ is a benzene ring which can be substituted by one substituent selected from the group consisting of a halogen atom, and an alkyl group, R R Ra is a hydrogen atom, or a C a compound of formula: wherein Ring A″ is a benzene ring which can be substituted by halogen, and R or a salt thereof.