Patent ID: 6153391
Filing Date: 2000-11-28
Classification: A61K,A61P,C07K,Y10S

Abstract:
A method for interfering with the binding of p53 to an oncogene protein or a fragment thereof that binds to p53, said method comprising:contacting said p53 and said oncogene protein or fragment thereof with a compound comprising (a) a peptide fragment not exceeding 28 amino acids of p53 protein which includes at least the sequence FxxLW (SEQ ID NO:4), wherein x is any amino acid, (b) a peptide analogue of the peptide fragment of (a) which comprises the sequence FxxLW (SEQ ID NO:4) or (c) an organic molecule that is modeled to resemble the three-dimensional structure of the amino acid residues FxxLW (SEQ ID NO: 4) as they appear at amino acid residues 19-23 in human p53, in an amount effective to interfere with the binding of said p53 to said oncogene protein or fragment thereof;wherein (a), (b) or (c) binds to said oncogene protein or fragment thereof and thereby interferes with its binding to said p53.