Patent ID: 6333344
Filing Date: 2001-12-25
Classification: A61P,C07D

Abstract:
A compound of the general formula: ##STR154##(a) wherein Ar is selected from the group consisting of substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;(b) wherein L is selected from the group consisting of --C(O)N(Q)CH.sub.2 --, and --CR.sup.10 R.sup.11 OCR.sup.12 R.sup.13 --; wherein Q is selected from the group consisting of hydrido, --(CH.sub.2).sub.m CO.sub.2 H and --(CH.sub.2).sub.m CO.sub.2 CH.sub.3 ; wherein m is selected from the group consisting of 1, 2, 3, and 4;(c) wherein each of R.sup.1, R.sup.2, R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 is independently selected from the group consisting of hydrido and lower alkyl;(d) wherein each of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from the group consisting of hydrido, acyl, amino, cyano, acyloxy, acylamino, carboalkoxy, carboxyamido, carboxy, halo, alkyl, heteroaryl, heterocyclyl, alkoxy, aryloxy, N-sulfonylcarboxyamido, N-acylamino, hydroxy, aryl, and cycloalkyl, --O(CH.sub.2).sub.n CO.sub.2 R.sup.17, --O(CH.sub.2).sub.n CONHSO.sub.2 R.sup.18, --(CH.sub.2).sub.n CO.sub.2 R.sup.19, --(CH.sub.2).sub.n CONHSO.sub.2 R.sup.20, --(O)NHCH(R.sup.22)CO.sub.2 R.sup.21, and --N(R.sup.23)(CH.sub.2).sub.n CO.sub.2 R.sup.24 ; alternatively, each of R.sup.3 and R.sup.4 together, R.sup.5 and R.sup.6 together, and R.sup.7 and R.sup.8 together are independently selected from the group consisting of ##STR155##wherein each of R.sup.14, R.sup.15 and R.sup.16 are independently selected from the group consisting of hydrido, alkyl and carboxy substituted alkyl; provided that at least five of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrido;(e) wherein Hat is selected from the group consisting of ##STR156##wherein X is selected from the group consisting of N and CR.sup.27 ; wherein Y is selected from the group consisting of NH, S and O; wherein Z is selected from the group consisting of N and CR.sup.28 ; wherein each of R.sup.25, R.sup.26, R.sup.27, and R.sup.28 is independently selected from the group consisting of nitro, halo, hydroxy, lower amino, lower alkyl, lower alkoxy, lower carboalkoxy and carboxy; and pharmaceutically-acceptable salts thereof; and wherein each of R.sup.29, R.sup.30, and R.sup.31 is selected from the group consisting of hydrido, alkyl aryl, nitro and amino.