Patent ID: 9198982
Filing Date: 2015-12-01
Classification: A61K,A61P,C12N,G01N

Abstract:
1. A method of identifying a candidate agent for the treatment of an excitotoxicity-related disorder, the method comprising: a) administering an excitotoxin to a non-human animal to provide an excitotoxin-induced animal model of epileptiform activity, wherein the non-human animal comprises an endogenous wild-type Tau allele; b) administering a test agent to the excitotoxin-induced animal model of epileptiform activity; c) performing an assay to quantify the effect, if any, of the test agent on the level of the wild-type tau gene product encoded by the wild-type Tau allele in a cell or a tissue of the animal model, thereby identifying a test agent that reduces the level of the wild-type tau gene product; d) performing an assay utilizing a test agent, previously identified in step (c) as reducing the level of the wild-type tau gene product, to quantify the effect, if any, of the test agent on the level of epileptiform activity in the animal model; and e) identifying a test agent that reduces epileptiform activity in the animal model in step (d) by at least about 10% as a candidate agent for the treatment of the excitotoxicity-related disorder.