Patent ID: 6045812
Filing Date: 2000-04-04
Classification: A61K,A61Q,C08B

Abstract:
Cyclodextrin derivatives, having formula (I) below:CD(OH).sub.l (OR.sub.1).sub.m (OR.sub.2).sub.n (I)in which:CD represents the basic skeleton of .alpha.-, .beta.- or .gamma.-cyclodextrin without the hydroxyl groups,OR.sub.1 represents a group, attached to the basic skeleton of the cyclodextrin, in which R.sub.1 represents a radical of formula (II), (III), (IV), (V) or (VI) below: ##STR3## or a mixture thereof, in which formulae R.sub.4, R.sub.6 and R.sub.7 represent a hydrogen atom or a C.sub.1 -C.sub.6 alkyl radical or a C.sub.1 -C.sub.12 alkoxy radical,R.sub.5 represents a C.sub.1 -C.sub.12 alkyl radical, q and r represent an integer equal to 0 or 1,R.sub.8 represents H or a C.sub.1 -C.sub.8 alkyl radical or a C.sub.1 -C.sub.4 alkoxy radical, s is an integer ranging from 0 to 4,OR.sub.2 represents a group, attached to the basic skeleton of the cyclodextrin, in which R.sub.2 represents a linear or branched C.sub.1 -C.sub.4 alkyl radical or a C.sub.2 -C.sub.4 hydroxyalkyl radical, wherein the hydrogen of the hydroxyl group of the said hydroxyalkyl radical is optionally substituted with another hydroxyalkyl group or with a radical R.sub.1 or a mixture thereof,l, m and n are statistical values such that m represents the number of groups OR.sub.1 attached directly to the basic skeleton of the cyclodextrin and is a statistical value other than 0,n represents the number of groups OR.sub.2 attached directly to the basic skeleton of the cyclodextrin and is a statistical value other than 0,l is a statistical value such that (l+m+n) is equal to 18, 21, 24 depending on whether CD is the basic skeleton of .alpha.-, .beta.- or .gamma.-cyclodextrin respectively.