Patent ID: 6596752
Filing Date: 2003-07-22
Classification: C07C,C07D

Abstract:
A compound of the formula (I): whereinn is an integer of 0 or 1; R1 is a hydrogen atom or methyl group, R2 is a group of the formula: â€”CN, â€”COOH, â€”(C1-6 alkylene)OH, â€”CH2O(C1-6 alkyl), â€”(C1-6 alkylene)COOH, â€”CH2O(C1-6 alkylene)O(C1-6 alkyl), â€”CH2O(C1-6 alkylene)COOH, â€”(C2-7 alkenylene)COOH, â€”CO(C1-6 alkylene)COOH, â€”CO(C2-7 alkenylene)COOH, â€”CO(C1-6 alkylene)O(C1-6 alkyl), â€”CO(C1-6 alkylene)CO(C1-6 alkyl), â€”CONH(C1-6 alkyl), â€”CONHO(C1-6 alkyl), â€”CONH(C1-6 alkylene)COOH, â€”CONH2, â€”CONH(C3-7 cycloalkyl), â€ƒâ€”CONHOCH2Ph, â€”CONH(C1-6 alkylene)CN, â€”COO(C1-6 alkyl), â€”CH2O(C1-6 alkylene)CONH2, â€”CONH(C1-6 alkylene)CONH2, â€”CONHOH, â€”NHCOOCH2Ph, R3 is a hydrogen atom or a methyl group; X is a methylene group or a group of the formula: â€”COâ€”, R4 is a hydrogen atom or a C1-6 alkyl group; R5 s a group of the formula: â€”COOH or an ester or an amide thereof, â€”(C1-6 alkylene)COOH or an ester or an amide thereof, â€”(C1-7 alkylene)O(C1-6 alkyl), â€”(C1-7 alkylene)OH, â€”COO(C1-6 alkyl), â€”CONH(C1-6 alkyl), or â€”CONH2; R6 is a substituent of the formula: wherein,R7, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”OH, â€”NO2, â€”NH2, â€”C1-C5 alkyl, â€”F, â€”Cl, â€”Br, â€”I, â€”COOH, â€”COO(C1-6 alkyl), â€”O(C1-C8 alkyl), â€”CONH (C1-6 alkylene)COOH, â€”OCH2(C3-C7 cycloalkyl) or a substituent of the formula R8, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”OH, â€”NH2, â€”NO2, â€”C1-C7 alkyl, â€”F, â€”Cl, â€”Br, â€”I, â€”CF3, phenyl, or â€”O(C1-6 alkyl); R9 is selected from a group of the formula: â€”H, â€”C1-C5 alkyl, â€”C3-C7 cycloalkyl, â€”(â€”C1-C6 alkylene)aryl, aryl, or a substituent of the formula: R10, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”F, â€”Cl, â€”Br, or â€”I, â€”NO2, â€”C1-6 alkyl or â€”C1-6 alkyl); R11 is selected from a group of the formula: R12, which occurs one or more times and which may be the same or different in each occurrence, is â€”H, â€”CF3, â€”OCF3, â€”F, â€”Br, â€”Cl, or â€”I; with the proviso that R1 and R3 must be different and also with the proviso that when R2 or R6 is a moiety of the formula â€”COOH or contains a moiety of the formula â€”COOH, then a pharmaceutically acceptable ester or a pharmaceutically acceptable amide thereof are included, and also with the proviso that when R7 is the formula R9 is other than hydrogen, and also with the proviso that when R6 is the formula R2 is or a pharmaceutically acceptable salt thereof.