Patent ID: 6770669
Filing Date: 2004-08-03
Classification: A61P,C07D

Abstract:
A method of treating schizophrenia, depression, psycose, disorders of the memory and the humour in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound of the formula whereinR1 is hydrogen or alkyl, R2 is selected from the group consisting of cycloalkyl, alkenyl, alkynyl, allenyl, allenylalkyl, cyanoalkyl, and â€”(CH2)gâ€”Z1R4, Z1 is selected from the group consisting of â€”Oâ€”, NR6, â€”Sâ€” and a bond, R4 is selected from the group consisting of alkenyl, allenylalkyl, alkynyl, and cyanoalkyl, R6 is hydrogen or alkyl, or R1 and R2 together with the nitrogen atom form a non-aromatic heterocycle with 4 to 8 members, the elements of the chain being selected from the group consisting of â€”CH(R9)â€”, â€”NR10â€”, â€”Oâ€”, â€”Sâ€” and â€”COâ€”, said heterocycle being substituted by at least one â€”(CH2)kâ€”Z2R11Orâ€”(CH2)kâ€”COR12, Z2 is selected from the group consisting of â€”Oâ€”, NR13â€”, â€”Sâ€” and a bond, R11, each time that it occurs is independently selected from the group consisting of alkenyl, alkynyl, allenyl, allenylalkyl and cyanoalkyl, R13, each time that it occurs is independently hydrogen or alkyl, R12, each time that it occurs is â€”NR14R15, R14 and R15, each time that they occur, are independently selected from the group consisting of hydrogen, alkyl, allenyl, allenylalkyll, alkenyl, alkynyl and cyanoalkyl, R9 and R10, each time that they occur, are hydrogen, X is â€”CO or â€”(CH2)mâ€”; R3 is hydrogen, alkyl or alkoxy of 1 to 6 carbon atoms; A is alkyl of 1 to 6 carbon atoms or a carbocyclic or heterocyclic aryl with 5 or 6 members containing 1 to 4 heteroatoms selected from the group consisting of â€”Oâ€”, S and â€”N, said aryl unsubstituted or substituted by at least one member of the group selected from the group consisting of alkyl, alkenyl and alkoxy of up to 6 carbon atoms, g, each time that is occurs, is independently, an integer from 1 to 6, m, k and n, each time that they occur, are independently, integers from 0 to 6; it being understood however that, when R3 is hydrogen or alkyl of 1 to 6 carbon atoms, then R1 and R2 do not represent, independently, hydrogen or alkyl, and moreover â€”NR1R2 do not represent one of the unsubstituted piperidynyl, morpholinyl, pyrrolidinyl groups or piperazinyl optionally substituted in position 4 by alkyl of 1 to 6 carbon atoms; or of a pharmaceutically acceptable salt thereof sufficient to treat said conditions.