Patent ID: 6407268
Filing Date: 2002-06-18
Classification: C07D

Abstract:
A carboxylic acid compound of formula Va or Vb whereinL1 is a nucleophilically replaceable leaving group selected from the group consisting of halogen, hetaryl and carboxylate; A is a radical of formula IIIa or formula IIIb R1 and R2 are independently selected from the group consisting of: hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, â€”OR10, â€”OCOR10, â€”OSO2R10, â€”S(O)nR10, â€”SO2OR10, â€”SO2NR3R10, â€”NR10SO2R10 and â€”NR10COR10; R3 is hydrogen, C1-C6-alkyl or phenyl, where the alkyl and phenyl radicals mentioned may be partially or fully halogenated and/or may carry one to three of the following groups: hydroxyl, mercapto, amino, cyano, R10, â€”OR10, â€”SR10, â€”NR3R10, &boxH;NOR10, â€”OCOR10, â€”SCOR10, â€”NR3COR10, â€”CO2R10, â€”COSR10, â€”CONR3R10, C1-C4-alkyliminooxy, C1-C4-alkoxyamino, C1-C4-alkylcarbonyl, C1-C4-alkoxy-C2-C6-alkoxycarbonyl, C1-C4-alkylsulfonyl, heterocyclyl, heterocyclyloxy, phenyl, benzyl, hetaryl, phenoxy, benzyloxy and hetaryloxy, where the last eight radicals may in turn be substituted; R4, R5, R6 and R7 are independently selected from the group consisting of: hydrogen, hydroxyl, mercapto, amino, halogen, C1-C6-alkyl, C3-C6-cycloalkyl, C4-C6-Cycloalkenyl, phenyl, â€”OR10, â€”S(O)nR10, â€”OS(O)nR10, â€”PO(OR10)2, â€”NR3R10, â€”Si(R10)3 and â€”OCOR10, where the alkyl and cycloalkyl radicals mentioned and R3 and R10 of the radicals â€”OR10, â€”S(O)nR10, â€”OS(O)nR10, â€”PO(OR10)2, â€”NR3R10, â€”Si(R10 )3, â€”OCOR10 are unsubstituted or partially or fully halogenated, and the unsubstituted or partially halogenated alkyl, cycloalkyl and R3 radicals optionally carry one to three of the following groups: hydroxyl, mercapto, amino, cyano, R10, â€”OR10, â€”SR10â€”NR3R10, &boxH;NOR10, â€”OCOR10, â€”SCOR10, â€”NR3COR10, â€”CO2R10, â€”COSR10, â€”CONR3R10, C1-C4-alkyliminooxy, C1-C4-alkoxyamino, C1-C4-alkylcarbonyl, C1-C4-alkoxy-C2-C6-alkoxycarbonyl, C1-C4-alkylsulfonyl, heterocyclyl, heterocyclyloxy, phenyl, benzyl, hetaryl, phenoxy, benzyloxy and hetaryloxy, where the last eight radicals may in turn be substituted, and the unsubstituted or partially halogenated R10 radicals optionally carry one to three of the following groups: hydroxyl, mercapto, amino, cyano, C1-C4-alkyliminooxy, C1-C4-alkoxyamino, C1-C4-alkylcarbonyl, C1-C4-alkoxy-C2-C6-alkoxycarbonyl, C1-C4-alkylsulfonyl, heterocyclyl, heterocyclyloxy, phenyl, benzyl, hetaryl, phenoxy, benzyloxy and hetaryloxy, where the last eight radicals may in turn be substituted; or R4 and R5 together form a C2-C5-alkylene or C2-C5-alkenylene chain which may be interrupted once or twice by a nitrogen or an oxygen atom, or may form a group &boxH;X, where X is an oxygen atom or a group CR3R10, NR10, NNR3R10, or NOR10; or R5 and R6 together form a C3-C4-alkylene or C3-C4-alkenylene chain which may be interrupted by a nitrogen or an oxygen atom, in the event that R5 and R6 are attached to adjacent carbon atoms and that R4 and R7 are each hydrogen; or R6 and R7 together form a C2-C5-alkylene or C2-C5-alkenylene chain which may be interrupted once or twice by a nitrogen or an oxygen atom, or may form a group &boxH;X, where X is an oxygen atom or a group CR3R10, NR10, NNR3R10, or NOR10; n is zero, one, two; R10 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl or phenyl-C1-C6-alkyl, where the alkyl radicals mentioned may be partially or fully halogenated and/or may carry one to three of the following groups: hydroxyl, mercapto, amino, cyano, C1-C4-alkyliminooxy, C1-C4-alkoxyamino, C1-C4-alkylcarbonyl, C1-C4-alkoxy-C2-C6-alkoxycarbonyl, C1-C4-alkylsulfonyl, heterocyclyl, heterocyclyloxy, phenyl, benzyl, hetaryl, phenoxy, benzyloxy and hetaryloxy, where the last eight radicals may in turn be substituted.