Patent ID: 8664227
Filing Date: 2014-03-04
Classification: A61P,C07D

Abstract:
1. A compound of formula I: where: Z represents a pyrrole selected from: Ar is selected from: R where R 1a is —C 1-6 alkyl, —C 0-6 alkylene-OR 1b , —C 3-7 cycloalkyl, —C 0-5 alkylene-NR 1b R 1b , pyridyl, isoxazolyl, methylisoxazolyl, pyrrolidinyl, morpholinyl, or phenyl optionally substituted with halo; where each R 1b is independently selected from H and —C 1-6 alkyl; a is 0, 1, or 2; R R R R 4d is H or —C(O)—R 4e ; and R 4e is —C 1-6 alkyl, —C 1-6 alkyl-NH 2 or aryl; and R where each ring in Ar is optionally substituted with 1 to 3 substituents independently selected from —OH, —C or a pharmaceutically acceptable salt thereof.