Patent ID: 6710044
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A chemical compound represented by the general formula (I) in which formula (I),o is 0, 1, 2 or 3; R1 represents a cyano group, or a group of the formula -alkyl-COOR2, -alkenyl-COOR2, â€”COâ€”R2, â€”COO(CH2)mR2, or â€”C(R3)&boxH;Nâ€”OR2, in which formulas: m is 0, 1, 2 or 3; R2 and R3 independently represents hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, benzyl, a 5- or 6-membered heterocyclic group, which 5- or 6-membered heterocyclic group may optionally be substituted one or more times with substituents selected from alkyl, cycloalkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, amino, or nitro; or R2 and R3 may indepenedently represent a group of the formula â€”(CH2)qâ€”NR4R5, â€”(CH2)qâ€”CONR4R5, â€”(CH2)qCOOR4, OR -alkyl-COOR4, in which formulas R4 and R5 independently represent hydrogen, alkyl or cycloalkyl; and q is 0, 1, 2 or 3; R11 represents a 4-morpholinyl group which group may optionally be substituted one or more times with substituents selected from C1-4-alkyl, C1-4-alkoxy, C1-4-alkoxycarbonyl, C1-4-alkoxycarbonyl-C1-4-alkyl, C1-4-alkenyloxycarbonyl-C1-4-alkyl, C1-4-alkenyl-(oxycarbonyl-C1-4-alkyl)2, acetyl, hydroxy-C1-4-alkyl, carboxamido, N-(C1-4-alkyl) carboxamido-C1-4-alkyl or N,N-di-(C1-4-alkyl)carboxamido-C1-4-alkyl; or a pharmaceutically acceptable salt thereof or an oxide thereof.