Patent ID: 6660737
Filing Date: 2003-12-09
Classification: A61K,A61P

Abstract:
A method of increasing vascularization of tissue in a mammalian subject in need of such treatment comprising administering to said subject a safe and effective amount of a compound having the structure: wherein(a) R1 is selected from the group consisting of aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; (b) R2 is hydrogen when Z is a single covalent bond or nil when Z is a double covalent bond, (c) R3 is selected from the group consisting of hydrogen and lower alkyl; (d) R4 is hydrogen when Z is a single covalent bond or nil when Z is a double covalent bond; (e) R5 is selected from the group consisting of hydrogen and lower alkyl; (f) R6 is selected from the group consisting of aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; or an optical isomer, diastereomer or enantiomer, or pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.