Patent ID: 6835752
Filing Date: 2004-12-28
Classification: A61P,C07B,C07C,C07D

Abstract:
A carboxylic acid compound of formula (I) wherein R1 is COOH or COOR6, R6 is C1-6 alkyl, (C1-4 alkylene)â€”R16, R16 is hydroxy, C1-4 alkoxy, COOH, C1-4 alkoxycarbonyl, CONR8R9, R8 and R9 each independently is hydrogen or C1-4 alkyl, A is C2-6 alkylene, R2 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, halogen atom, CF3, cyano, nitro, hydroxy, NR11R12, CONR11R12, SO2NR11R12, orâ€”S(O)xâ€”(C1-6)alkyl, m is 0, 1 or 2, when m is 2, then two R2 may be same the or different, R11 and R12 each independently is hydrogen or C1-4 alkyl, x is 0, 1 or 2, B ring is phenyl, R3 is hydrogen or C1-4 alkyl, R4 is (1) C1-8 alkyl, (2) C2-8 alkenyl, (3) C2-8 alkynyl, (4) C3-6 cycloalkyl, (5) hydroxy, (6) C1-4 alkoxy, (7) C1-4 alkoxy(C1-4)alkoxy, or (8) C1-8 alkyl substituted by 1-2 of substituents selected from halogen atom, hydroxy, C1-6 alkoxy, C1-4 alkoxy(C1-4)alkoxy, phenyl and C3-6 cycloalkyl, R5 is unsubstituted phenyl or naphthyl or phenyl or naphthyl substituted by 1-2 of R13, R13 is C1-6 alkyl, C1-6 alkoxy, halogen atom, CF3, cyano, C1-4 alkoxy(C1-4)alkyl, phenyl, phenyl(C1-6)alkyl, â€”(C1-4 alkylene)yâ€”Jâ€”(C1-8 alkylene)zâ€”R14, benzoyl or thiophenecarbonyl and two R13 may be the same or different, y is 0 or 1, z is 0 or 1, R14 is phenyl or pyridyl, J is oxygen, S(O)t or NR15, t is 0, 1 or 2, R15 is hydrogen, C1-4 alkyl or acetyl; or non-toxic salts.