Patent ID: 9050279
Filing Date: 2015-06-09
Classification: A61K

Abstract:
1. A method for treating damage caused by stroke in a mammalian subject, comprising administering to the mammalian subject who has suffered a stroke an immune-modulatory effective amount of a composition comprising a purified MHC class II polypeptide comprising: covalently linked first and second domains, wherein the first domain is a mammalian MHC class II HLA-DR β1 domain and the second domain is a mammalian MHC class II HLA-DR α1 domain, wherein the amino terminus of the second domain is covalently linked to the carboxy terminus of the first domain, and wherein the MHC class II molecule does not include an α2 or a β2 domain, wherein one or more hydrophobic residues selected from residues V6, I8, A10, F12, and L14 of the α1 domain are substituted with a polar or charged residue, wherein residue V6 corresponds to position 4 of SEQ ID NO: 86, residue I8 corresponds to position 6 of SEQ ID NO: 86, residue A10 corresponds to position 8 of SEQ ID NO: 86, residue F12 corresponds to position 10 of SEQ ID NO: 86, and residue L14 corresponds to position 12 of SEQ ID NO: 86; and an antigenic determinant, wherein the antigenic determinant is MOG 35-55, wherein the MHC class II polypeptide modulates one or more immune responses or immune regulatory activities of a T-cell in the subject.