Patent ID: 6080429
Filing Date: 2000-06-27
Classification: A61K,C12N,Y10S

Abstract:
A method for preparing microspheres wherein an active agent is dispersed within a polymer matrix by a water-in-oil or a solid-in-oil process comprising(a) dissolving a polymer in an organic solvent to produce a solution;(b) adding an active agent or an aqueous solution thereof to the solution of step (a) to produce a polymer-active agent solid-in-oil or water-in-oil first emulsion or suspension;(c) extracting the excess organic solvent from the first emulsion or suspension with an aqueous solution to produce microspheres;(d) removing the aqueous solution sufficient to provide a final product with less than 20% residual moisture by drying the microspheres of step (c) in a fluidized bed; and(e) recovering the microspheres.