Patent ID: 9222939
Filing Date: 2015-12-29
Classification: C07K,G01N

Abstract:
1. A method of identifying a cancer stem cell in a sample comprising a population of mammalian cells, the method comprising: providing a sample comprising a population of mammalian cells that is suspected of containing a cancer stem cell; detecting a cell having two or more midbody scars by a method comprising contacting the sample with an antibody or an antigen-binding portion thereof that binds specifically to a polypeptide component of a midbody scar selected from the group consisting of: mitotic kinesin-like protein 1 (MKLP1), Epsilon tubulin (ε-tubulin), Centrosomal Protein 55KDa (Cep55), and Aurora B kinase; detecting binding of the antibody or antigen-binding portion thereof to the polypeptide component, wherein a ring structure not at a midbody or centrosome is a midbody scar; and identifying a cell in the sample having two or more midbody scars as being a cancer stem cell.