Patent ID: 6322790
Filing Date: 2001-11-27
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A method of eliciting an immune response in an individual against an infectious agent or against a type of cancer comprising:(a) administering to the individual a first composition comprising a purified first complex consisting essentially of a first heat shock protein noncovalently bound to a first antigenic molecule, in which either (i) the first complex is obtained from tissue infected with said infectious agent, or from cancerous tissue of said type of cancer or a metastasis thereof, respectively, or (ii) the first antigenic molecule is an antigen of said infectious agent or is a peptide or protein that displays antigenicity of said antigen of said infectious agent, or is a tumor-specific antigen of said type of cancer or is a peptide or protein that displays antigenicity of said tumor-specific antigen of said type of cancer, respectively; and(b) administering to tile individual a second composition comprising antigen presenting cells sensitized in vitro with a sensitizing amount of a purified second complex of a second heat shock protein noncovalently bound to a second antigenic molecule, in which either (i) the second complex is obtained from tissue infected with said infectious agent, or from cancerous tissue of said type of cancer or a metastasis thereof, respectively, or (ii) the second antigenic molecule is an antigen of said infectious agent or is a peptide or protein that displays antigenicity of said antigen of said infectious agent, or is a tumor-specific antigen of said type of cancer or is a peptide or protein that displays antigenicity of said tumor-specific antigen of said type of cancer, respectively;in which said second composition is administered before, concurrently or after administration of the first composition.