Patent ID: 8318816
Filing Date: 2012-11-27
Classification: A61K,A61P

Abstract:
1. A method for disrupting a cell or organelle membrane comprising delivering to the cell or organelle a composition comprising a water-soluble hydrophilic conjugate having a hydrophobic component linked to a hydrophilic component by a pH-sensitive linkage, wherein the pH-sensitive linkage is stable at a pH between 6.8 and 8 and hydrolyzed at a pH less than 6.5 to release the hydrophobic component; wherein the hydrophilic component comprises a polyalkylene oxide; wherein the hydrophobic component is an endosomal membrane disruptive vinyl copolymer prepared from alkyl substituted methacrylates, cationic monomers, and polyethylene glycol amino acetal monomers that provides transport through the endosomal membrane when released from the hydrophilic conjugate.