Patent ID: 6054475
Filing Date: 2000-04-25
Classification: A61P,C07D,C07F

Abstract:
A compound of formula I ##STR10## in which R1 is 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or 1-4C-alkoxy wherein more than half of the available hydrogen atoms are replaced by fluorine,R2 is 1-4C-alkyl andR3 is hydrogen or 1-4C-alkyl,or in whichR2 and R3, together and including the two carbon atoms to which they are bonded, are a spiro-linked 5-, 6- or 7-membered hydrocarbon ring, optionally interrupted by an oxygen atom or an amino (--NH--) group,R4 is hydrogen, hydroxyl, nitro, cyano, carboxyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl,A is B, --CH(R5)-- or >C.dbd.N--R6, whereB is oxygen (--O--), amino (--NH--), sulfinyl (--S(O)--), sulfonyl (--S(O).sub.2 --) or carbonylimino (--C(O)NH--) andR5 is aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, hydroxylaminocarbonyl (--C(O)NHOH), 1-4C-alkoxyaminocarbonyl or a radical of formula (a) ##STR11## where R51 is hydrogen, 1-4C-alkyl or aryl andR52 is hydrogen, 1-4C-alkyl or aryl,where aryl is a phenyl, pyridyl, benzyl or phenethyl radical which can be unsubstituted or mono- or disubstituted by hydroxyl, 1-4C-alkoxy, halogen, amino, cyano or nitro,R6 is hydroxyl or 1-4C-alkylcarbonyloxy,or a salt thereof.