Patent ID: 8933697
Filing Date: 2015-01-13
Classification: A61B,G01R

Abstract:
1. A method for measuring a ratio of two or more spectrally distinct chemical species in exchange, the method comprising the steps of: generating a first RF excitation pulse that selectively tips a first chemical species by a first tip angle; quantifying the first chemical species based on resonance signals generated in response to the first RF excitation pulse; under equilibrium conditions between the first chemical species and a second chemical species, generating a second RF excitation pulse that tips at least the second chemical species by a second tip angle that is different than the first tip angle; quantifying the second chemical species based on resonance signals generated in response to the second RF excitation pulse; repeating, for a set number of iterations, the steps of generating the first RF excitation pulse, quantifying the first chemical species, generating the second RF excitation pulse, and quantifying the second chemical species; and obtaining a ratio of the first chemical species and the second chemical species in exchange correcting for the differential effect of the first tip angle and the second tip angle.