Patent ID: 8859526
Filing Date: 2014-10-14
Classification: A61K,A61P,Y10S

Abstract:
1. A composition comprising: a non-anticoagulant sulfated polysaccharide (NASP) selected from the group consisting of glycosaminoglycans, carrageenans, substituted heparins, periodate-oxidized heparins, fucoidans, fucopyranon sulfates, dermatan sulfates, pentosan polysulfates, chemically sulfated laminarin, chemically sulfated alginic acid, chemically sulfated pectin and dextran sulfates; one or more factors selected from the group consisting of factor XI, factor XII, prekallikrein, high molecular weight kininogen, factor V, factor VII, factor VIII, factor IX, factor X, factor XIII, factor II, von Willebrands factor, tissue factor, factor VIIa, factor Va, and factor Xa, factor IXa, factor Xla, factor XIIa, and Villa; and one or more pharmaceutically acceptable excipients; wherein the concentration of the NASP in the composition is from 10 nM to 500 nM.