Patent ID: 6407216
Filing Date: 2002-06-18
Classification: A01K,C07K

Abstract:
An antibody which specifically binds to a vertebrate Smoothened polypeptide, wherein said Smoothened polypeptide:(a) directly binds Patched; and (b) is encoded by a nucleic acid which hybridizes to the complement of the nucleic acid sequence encoding residues 1 to 787 of SEQ ID NO:4 under the following conditions: hybridization at 42Â° C. in 50% formamide, 5Ã—SSC, 10Ã—Denhardt's, 0.05M sodium phosphate (pH 6.5), 0.1% sodium pyrophosphate, 50 &mgr;g/ml sonicated salmon sperm; and rinsing with 2Ã—SSC and washing with 0.5Ã—SSC, 0.1% SDS at 42Â° C.