Patent ID: 6488933
Filing Date: 2002-12-03
Classification: A61K,C07K

Abstract:
A composition consisting essentially of an antigen and a carrier, wherein the antigen is recognized by inflammatory T cells associated with the pathogenesis if diabetes and is peptide p277 (residues 437-460 of SEQ ID NO:1) or peptide p277 (Val6-Val11) (SEQ ID NO:4), and wherein the carrier induces a TH1â†’TH2 shift in the cytokines produced by said T cells and is a fat emulsion consisting essentially of 10-20 % triglycerides of plant and/or animal origin, 1.2-2.4% phospholipids of plant and/or animal origin, 2.25-4.5% osmoregulator, 0-0.05% antioxidant, and sterile water.