Patent ID: 8318735
Filing Date: 2012-11-27
Classification: A61K,A61P,C07D

Abstract:
1. A compound having the formula: or a pharmaceutically acceptable salt, ester, prodrug or stereoisomer thereof, wherein the dashed line indicates an optional and additional bond, and wherein: R R R each occurrence of R R R R R Ar is -arylene- or -heteroarylene-, wherein the arylene or heteroarylene is joined via 2 of its adjacent ring carbon atoms, and wherein the -arylene- or -heteroarylene- can be substituted with up to 4 substituents, which may be the same or different, and are independently selected from -halo, alkyl, alkoxy, aryloxy, —SR W is —NH— or —C(R Y is —H, -halo, -alkyl or —CN; and Z is —CR