Patent ID: 7265109
Filing Date: 2007-09-04
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein R 1 is selected from the group consisting of aryl; substituted aryl; heterocyclyl which is a 5- to 10-membered heterocyclic ring which has at least one ring hetero atom selected from nitro, oxygen and sulfur; substituted heterocyclyl; amino; and alkoxy; wherein substituted aryl is aryl which is substituted with a group selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, amino, alkyl, cycloalkyl, alkoxy, alkylcarbonyl, cyano, carbamoyl, alkoxycarbamoyl, methylendioxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkyaminocarbonyl, dialkylaminocarbonyl, hydroxy, nitro, alkyl-SO 2 —, amino-SO 2 —, and cycloalkyl, and wherein substituted heterocyclyl is heterocyclyl which is substituted on at least one carbon atom with a group selected from the group consisting of cyano, trifluoromethyl, trifluoromethoxy, alkyl-SO 2 —, amino-SO 2 —, halogen, alkoxy, hydroxy, amino, cycloalkyl, alkylcarbonyl, aminocarbonyl nitro, alkyl, and alkoxycarbonyl; R 2 is hydrogen, alkyl or halogen; R 3 is alkyl, halogen or trifluoromethyl; A 1 is C-R 3 or nitrogen; A 2 is piperidine or pyrrolidine, wherein the nitrogen atom of the piperidine and pyrrolidine ring is attached to A 3 ; A 3 is —S(O) 2 — or —C(O)—; n is zero, 1 or 2; or a pharmaceutically acceptable salt or ester thereof.