Patent ID: 6204286
Filing Date: 2001-03-20
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula: ##STR19##wherein:A is CH.sub.2 ;B, D and E are CH;Y is(a) phenyl, optionally substituted with 1-3 substituents independently selected from R.sup.4 ;(b) naphthyl, optionally substituted with 1-3 substituents independently selected from R.sup.4 ;(c) C.sub.3 -C.sub.8 cycloalkyl, optionally substituted with 1-2 substituents independently selected from R.sup.4 ;(d) C.sub.3 -C.sub.8 cycloalkenyl, optionally substituted with 1-2 substituents independently selected from R.sup.4 ;Z.sup.1 is(b) --O(CH.sub.2).sub.p CR.sup.5 R.sup.6 --;(c) --O(CH.sub.2).sub.p W(CH.sub.2).sub.q ; or(d) --OCHR.sup.2 CHR.sup.3 --;G is ##STR20##W is(a) --CH.sub.2 --;(b) --CH.dbd.CH--;(c) --O--;(d) --NR.sup.2 --;(e) --S(O).sub.n --;(f) ##STR21##(g) --CR.sup.2 (OH);(h) --CONR.sup.2 --;(i) --NR.sup.2 CO--;(j) ##STR22##(k) --C.dbd.C--;R is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.2 and R.sup.3 are independently(a) hydrogen; or(b) C.sub.1 -C.sub.4 alkyl;R.sup.4 is(a) hydrogen;(b) halogen;(c) C.sub.1 -C.sub.6 alkyl:(d) C.sub.1 -C.sub.4 alkoxy;(e) C.sub.1 -C.sub.4 acyloxy;(f) C.sub.1 -C.sub.4 alkylthio;(g) C.sub.1 -C.sub.4 alkylsulfinyl;(h) C.sub.1 -C.sub.4 alkylsulfonyl;(i) hydroxy (C.sub.1 -C.sub.4)alkyl;(j) aryl (C.sub.1 -C.sub.4)alkyl;(k) --CO.sub.2 H;(l) --CN;(m) --CONHOR;(n) --SO.sub.2 NHR;(o) --NH.sub.2 ;(p) C.sub.1 -C.sub.4 alkylamino;(q) C.sub.1 -C.sub.4 dialkylamino;(r) --NHSO.sub.2 R;(s) --NO.sub.2 ;(t) --aryl; or(u) --OH;R.sup.5 and R.sup.6 are independently C.sub.1 -C.sub.8 alkyl or together form a C.sub.3 -C.sub.10 carbocyclic ring;e is, 1;m is 1, 2 or 3;n is 0, 1 or 2;p is 0, 1, 2 or 3;q is 0, 1, 2 or3;and optical and geometric isomers thereof; and nontoxic pharmacologically acceptable acid addition salts, N-oxides, esters, and quaternary ammonium salts thereof.