Patent ID: 6797703
Filing Date: 2004-09-28
Classification: A61K,C07K

Abstract:
A method of generating hyaline cartilage, comprising:a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding transforming growth factor &bgr;1 (TGF-&bgr;1) operatively linked to a promoter; b) transfecting in vitro a population of chondrocytes with said recombinant vector, resulting in a population of transfected chondrocytes; and c) injecting a composition consisting of the transfected population of chondrocytes and a pharmaceutically acceptable carrier into a joint space of a mammal such that expression of the DNA sequence encoding TGF&bgr;1 within the joint space occurs resulting in the generation of hyaline cartilage in the joint space.