Patent ID: 6503899
Filing Date: 2003-01-07
Classification: A61K,A61P,C07D

Abstract:
A compound of formula (I): wherein:R1 is selected from the group consisting of H, C1-8alkyl and C1-8alkylenearyl; each R2, independently, is selected from the group consisting of halo, C1-8alkyl, C1-8alkoxy, aryl, and OH; R3 is selected from the group consisting of hydrogen, C1-8alkyl, aryl, heteroaryl, C(&boxH;O)Ra, C(&boxH;O)ORa, C(&boxH;O)NRaRb, C(&boxH;O)SRa, C(&boxH;S)NRaRb, SO2Ra, SO2NRaRb, S(&boxH;O)Ra, S(&boxH;O)NRaRb, C(&boxH;O)NRaC1-6alkyleneORa, C(&boxH;O)NRaC1-6alkyleneHet, C(&boxH;O)C1-6alkylenearyl, C(&boxH;O)C1-6alkyleneheteroaryl, C1-6alkylenearyl, C1-6alkyleneheteroaryl, C1-6alkyleneHet, C1-6alkyleneC(&boxH;O)C1-6alkylenearyl, C1-6alkyleneC(&boxH;O)C1-6alkyleneheteroaryl, C1-6alkyleneC(&boxH;O)Het, C1-6alkyleneC(&boxH;O)NRaRb, C1-6alkyleneORa, C1-6alkyleneNRaC(&boxH;O)Ra, C1-6alkyleneOC1-6alkyleneORa, C1-6alkyleneNRaRb, C1-6alkyleneC(&boxH;Q)ORa, C1-6alkyleneOC1-6alkyleneC(&boxH;O)ORa, C1-6alkyleneC(&boxH;O)aryl, C1-6alkyleneC(&boxH;O)heteroaryl, C1-6alkyleneOC1-6alkylenearyl, C1-6alkyleneOC1-6alkyleneheteroaryl, C1-6alkyleneOC1-6alkyleneHet, C1-6alkyleneSRa, C1-6alkyleneSO2Ra, C1-6alkyleneS(&boxH;O)Ra; C1-6alkyleneSO2NRaRb, and C1-6alkyleneNHSO2Ra; each R4, independently, is selected from the group consisting of halo, OH, CN, NO2, CF3, CF3O, NRaRb, C1-8alkyl, C1-8alkoxy, C1-8alkanoyl, C1-8alkoxycarbonyl, C1-8alkanoyloxy, aryl, heteroaryl, C1-6alkylenearyl, and C1-6alkyleneheteroaryl; each R5, independently, is selected from the group consisting of halo, C1-8alkyl, C1-8alkoxy, and OH; m is 0, 1, 2, 3, 4, 5, 6, 7, or 8; n is 0, 1, 2, 3, 4, 5, or 6; p is 0, 1; or 2; bond a and bond b represented by - - - are each independently a single bond or a double bond; Ra and Rb, independently, are selected from the group consisting of hydrogen, C1-8alkyl, aryl, heteroaryl, arylC1-3alkyl, heteroarylC1-3alkyl, C1-3alkylenearyl, C1-3alkyleneheteroaryl, and Het; or a pharmaceutically acceptable salt or solvate thereof.