Patent ID: 7467046
Filing Date: 2008-12-16
Classification: C12N,C12Q,C12Y,G01N,G16B

Abstract:
1. A method for designing a ligand for a farnesyl transferase (ETase), the method comprising: (a) providing a molecule that binds to a geranylgeranyl transferase type I (GGTase-l) a (b) determining a moiety of the molecule that interacts with the GGTase-I a (c) modifying the moiety to produce a modified molecule; wherein the modifying comprises modifying a moiety that interacts with one or more of residues Thr491β, Phe 106β, and Leu 361β of a human GGTase-I polypeptide; (d) modeling a first interaction between the modified molecule and the GGTase-I a (e) modeling a second interaction between the modified molecule with an FTase a (f) identifying in a modified molecule that is predicted to be unable to bind to the GGTase-I a (g) displaying a structure of the modified molecule identified in step (f), whereby a ligand for a FTase is designed.