Patent ID: 8772298
Filing Date: 2014-07-08
Classification: A61P,C07D

Abstract:
1. A method for the treatment of a disease of the airways accompanied by increased production of mucus, wherein the disease is selected from chronic bronchitis, chronic obstructive bronchitis (COPD), asthma, bronchiectasis, allergic or non-allergic rhinitis or sinusitis, cystic fibrosis, α1-antitrypsin deficiency, coughs, pulmonary emphysema, pulmonary fibrosis and hyperreactive airways, comprising administering to a patient a therapeutically effective amount of a compound of formula (I) wherein R R a group selected from among F, Cl, Br, I, OCH a group selected from among C phenyl, phenyl-O, phenyl-C and R or a group selected from among F, Cl, Br and CH R R R a group selected from among F, Cl, Br, I, OH, C or R or or R while the pyrrolidinyl, piperidinyl, azepan-1-yl, piperazinyl, 1,4-diazepan-1-yl, morpholinyl- and 1,4-oxazepan-4-yl groups mentioned above in the definition of the group R and wherein the above-mentioned phenyl groups are mono- or disubstituted by groups R R and unless stated otherwise, the above-mentioned alkyl groups may be straight-chain or branched, A denotes a C and R optionally in the form of the tautomers, the racemates, the enantiomers, the diastereomers and the mixtures thereof, or a pharmacologically acceptable acid addition salt thereof.