Patent ID: 6172227
Filing Date: 2001-01-09
Classification: A61P,C07D

Abstract:
A compound of the formula I: ##STR21##or physiologically acceptable salt thereof in which X is a direct bond, C.sub.1-4 alkylene, C.sub.1-4 alkyleneoxy, C.sub.1-4 alkoxyphenyl or phenyl C.sub.1-4 alkylene; Y is a direct bond or C.sub.1-2 alkyl; R.sup.1 is (i) 5-15 membered cyclic or fused heterocompound comprising 3-14 carbon atoms and one or two atoms selected from a group consisting of nitrogen, oxygen and sulfur, with the proviso that no oxygen-oxygen bond or sulphur-oxygen bond is formed, and which is substituted with one or two substituents selected from a group consisting of hydrogen, halogen, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.3-6 alkenyl and halogen C.sub.1-4 alkoxy, (ii) C.sub.4-10 carbocyclic compound or (iii) hydroxy C.sub.1-4 alkoxy; R.sup.2 is 5-15 membered cyclic or fused heterocompound comprising 3-14 carbon atoms and one or two nitrogen atoms and, optionally, one oxygen or sulfur atom, and which is substituted with one or two substituents selected from a group consisting of hydrogen, hydroxy, halogen, nitro, hydroxy C.sub.1-5 alkyl, C.sub.1-6 alkyl, C.sub.3-6 alkenyl and halogen C.sub.1-4 alkoxy; R.sup.3 is hydrogen, ##STR22##in which R.sup.4 and R.sup.5 are each independently selected from a group consisting of hydroxy, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, halogen C.sub.1-6 alkyl, halogen C.sub.2-6 alkenyl and C.sub.1-4 alkoxy or R.sup.4 and R.sup.5 represent each independently ##STR23##in which R.sup.6 is selected from a group consisting of hydrogen, hydroxy, C.sub.1-6 alkyl, C.sub.3-6 alkenyl, halogen C.sub.1-6 alkyl, halogen, nitro and C.sub.1-4 alkoxy.