Patent ID: 7491748
Filing Date: 2009-02-17
Classification: A61P,C07C,C07D

Abstract:
1. A carboxylic acid compound of formula (I): wherein R R R R (i) hydrogen, (ii) C1-6 alkyl, (iii) hydroxy, (iv) —COR (v) a C3-15 mono-, bi- or tri-carbocyclic ring or a 3- to 15-membered mono-, bi- or tri-heterocyclic ring which is substituted with 1-5 of R (vi) C1-4 alkyl substituted with a C3-15 mono-, bi- or tri-carbocyclic ring or a 3- to 15-membered mono-, bi- or tri-heterocyclic ring which is substituted with 1-5 of R R R R R R A is (i) C1-6 alkylene, (ii) C2-6 alkenylene, the alkylene and alkenylene in A may be substituted with 1-6 of the following substituents of (a)-(i): (a) C1-6 alkyl, (b) C1-6 alkoxy, (c) halogen, (d) CHF B ring is a benzene R m is 0, 1 or 2, n is 1 Q is (1) (i) —(C1-4 alkylene)-Z-Cyc3, (i) hydroxyl(C1-4) alkyl, (ii) C1-4 alkoxy(C1-4) alkyl, or (iii) —(C1-4 alkylene)-O-benzyl, R R the C3-7 mono-carbocyclic ring and 3- to 7-membered mono-heterocyclic ring in R (a) C1-6 alkyl, (b) C2-6 alkenyl, (c) C2-6 alkyl, (d) c1-6 alkoxy, (e) C1-6 alkylthio, (f) halogen, (g) CHF M is —O—, —S—, C1-4 alkylene, —O—(C1-4 alkylene)-, —S—(C1-4 alkylene)-, —(C1-4 alkylene)-O— or —(C1-4 alkylene)-S—, R Z is —O—, p is 0, 1 or 2, Cyc3 is a benzene which is substituted with 1-5 of R D is —CONH—CH R two R Cyc9 is a phenyl, R R R R R R Cyc10 is a C3-12 mono- or bi-carbocyclic ring or a 3- to 12-membered mono- or bi-heterocyclic ring which is substituted with 1-5 of substitutes of the following (a)-(j) or unsubstituted, (a) C1-4 alkyl, (b) C2-5 acyl, (c) 1-4 alkoxy, (d) halogen, (e) hydroxy, (f) nitro, (g) cyano, (h) amine, (i) CF W is —O—, —S(O) R or a non-toxic salt thereof.