Patent ID: 7727402
Filing Date: 2010-06-01
Classification: B01D,G01N,Y10T

Abstract:
1. A process for the manufacture of a chromatography cartridge containing a selected volume of solid particulate packing material at a selected packing volume, said process comprising: (a) charging a first chamber with a slurry of said solid particulate packing material in a carrier liquid, the packing material in said slurry being of a quantity that when fully packed fills said selected packing volume, said first chamber having a longitudinal axis, an open first end, and a second end containing a liquid discharge port adapted to allow passage of liquid while blocking passage of said solid particles, (b) joining a second chamber to said first chamber, said second chamber having an open first end, a second end containing a vent port adapted to allow passage of liquid while blocking passage of said solid particles, and an internal cavity having a volume equal to said selected volume of solid particulate packing material, by inserting said open first end of said second chamber into said open first end of said first chamber, and (c) sliding said second chamber further into said first chamber, thereby forcing substantially all of said solid particulate matter plus at least a portion of said carrier liquid into said second chamber through said open end of said second chamber while compressing said particulate matter in said second chamber to said packing volume and discharging excess carrier liquid through said liquid discharge port, said vent port, or both.