Patent ID: 8945554
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K

Abstract:
1. A method of delivering a diagnostic or therapeutic agent comprising administering to a subject a chimeric, humanized or human Class I anti-CEA antibody or antigen-binding fragment thereof, comprising the light chain variable region CDR (complementarity determining region) sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6), wherein the Class I anti-CEA antibody or antigen-binding fragment thereof is conjugated to at least one diagnostic or therapeutic agent selected from the group consisting of an antibody, an antigen-binding antibody fragment, a cytotoxic agent, a chemotherapeutic agent, a radionuclide, boron atoms, an immunomodulator, a photoactive therapeutic agent, an immunoconjugate, an oligonucleotide, a hormone, a radiological contrast agent, a paramagnetic ion, a metal, a fluorescent label, a chemiluminescent label, and an ultrasound contrast agent.