Patent ID: 8323956
Filing Date: 2012-12-04
Classification: C12Q,G01N

Abstract:
1. A distal tip of a biosensor transducer for use in detecting an organic compound susceptible to deamination, the tip comprising: a biocomponent comprising one or more enzymes for carrying out deamination of the organic compound, said biocomponent immobilized to a surface of the tip by one or more of (a) entrapment within a hydrogel; (b) entrapment within a polymeric network; (c) encapsulation; (d) covalent bonding; and (e) adsorption; wherein said biocomponent has been treated to maintain a period of enzymatic efficacy; and wherein said biocomponent is stabilized to said tip by one or more of crosslinking a surface of said immobilized biocomponent, crosslinking a polymer layer to said biocomponent, adding a gel-hardening agent to said biocomponent, adding a stabilizing agent to said biocomponent, and modifying a component used to immobilize said biocomponent to said surface of the tip.