Patent ID: 9068011
Filing Date: 2015-06-30
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated human monoclonal antibody which binds human c-Met and comprises: (i) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 34, 185 and 36 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 38, 39 and 206, (ii) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 191, 192 and 193 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 78, 79 and 208, (iii) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 194, 195 and 196 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 209, 210 and 104; (iv) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 197, 198 and 116 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 118, 119 and 211, or (v) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 199, 200 and 201 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO: 126, 212 and 128.