Patent ID: 6770654
Filing Date: 2004-08-03
Classification: A61K,A61P,C07D

Abstract:
An indole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is hydrogen, C1-5 alkyl, C4-7 cycloalkylalkyl, C5-7 cycloalkenylalkyl, C6-12 aryl, C7-13 aralkyl, C3-7 alkenyl, furan-2-yl-alkyl (wherein the alkyl moiety is C1-5), or thiophen-2-yl-alkyl (wherein the alkyl moiety is C1-5); R2 is hydrogen, hydroxy, C1-5 alkoxy, or C1-5 aliphatic acyloxy; R3 is hydrogen, hydroxy, C2-5 alkoxy, C1-5 aliphatic acyloxy, or C7-13 aralkyloxy; â€”Zâ€” is a crosslinkage having 2 to 5 carbon atoms; m is an integer from 0 to 3; n is an integer from 0 to 10; m number of R4 groups and n number of R5 groups are independently fluoro, chloro, bromo, iodo, nitro, C1-5 alkyl, hydroxy, C1-5 alkoxy, trifluoromethyl, trifluoromethoxy, cyano, phenyl, isothiocyanato, SR6, SOR6, SO2R6, (CH2)pOR6, (CH2)pCO2R6, SO2NR7R8, CONR7R8, (CH2)pNR7R8, or (CH2)pN(R7)COR8 (wherein p is an integer from 0 to 5; R6 is hydrogen or C1-5 alkyl; and R7 and R8 are independently hydrogen, C1-5 alkyl, or C4-7 cycloalkylalkyl), among n number of R5 groups, two R5 groups bound to the same carbon atom become an oxygen atom to form oxo, or among m number of R4 groups and n number of R5 groups, two adjacent R4 groups, two adjacent R5 groups, or R4 and R5 may be bound to each other to form a benzene, pyridine, cyclopentane, cyclohexane, or cycloheptane fused ring, with the proviso that both in and n cannot be O simultaneously and furthermore, at least one of R4 and R5 groups represents hydroxy, or two R5 groups bound to the same carbon atom form oxo; R9 is hydrogen, C1-5 alkyl, C2-5 alkenyl, C7-13 aralkyl, C1-3 hydroxyalkyl, (CH2)pOR6, or (CH2)pCO2R6, wherein p and R6 are as defined above; and R10 and R11 are bound to each other to form â€”Oâ€”, â€”Sâ€”, or â€”CH2â€”, or R10 is hydrogen while R11 is hydrogen, hydroxy, C1-5 alkoxy, or C1-5 aliphatic acyloxy.