Patent ID: 6015831
Filing Date: 2000-01-18
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR16## wherein each R.sup.1 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, alkoxy, substituted alkoxy, cycloalkyl and halo;R.sup.2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl and cycloalkylalkyl;R.sup.3 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl;each W is independently selected from the group consisting of --SR.sup.4, --S(O)R.sup.5, --SO.sub.2 R.sup.6, --SO.sub.3 Y, and --SO.sub.2 NR.sup.7 R.sup.8 ;wherein Y is hydrogen or a pharmaceutically acceptable cation;R.sup.4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl;R.sup.5 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl;R.sup.6 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl;R.sup.7 and R.sup.8 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, aralkyl, aryl, cycloalkyl, cycloalkylalkyl and cycloalkenyl; or R.sup.7 and R.sup.8 together with the nitrogen atom to which they are attached can form a heterocyclic ring containing from 2 to 8 carbon atoms and optionally from 1 to 3 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;m is an integer from 1 to 3; and n is an integer from 0 to 2, provided that m+n=3; and optical isomers and racemates thereof, and pharmaceutically acceptable salts thereof.