Patent ID: 6143764
Filing Date: 2000-11-07
Classification: A61P,C07D

Abstract:
A quinoline derivative, or a pharmaceutically acceptable salt thereof, wherein the derivative is represented by the following formula (I): ##STR321## wherein R.sub.1 and R.sub.2 are each independently H, C.sub.1 -C.sub.5 -alkyl or together form C.sub.1 -C.sub.3 -alkylene,wherein W is CH,wherein X is O, S or CH.sub.2,wherein Q is a group represented by the following formula (III), (IV) or (V): ##STR322## wherein m is 1, 2 or 3, wherein each R.sub.3 ' is independently OH, C.sub.1 -C.sub.5 -alkyl or C.sub.1 -C.sub.4 -alkoxy,wherein Y and Z are each independently N or CH,wherein R.sub.4 is H, C.sub.1 -C.sub.5 -alkyl or C.sub.2 -C.sub.4 -acyl,wherein j and k are each independently 0 or 1,wherein each R.sub.5 is independently H or C.sub.1 -C.sub.4 -alkyl,wherein A is C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.5 -alkenyl, cyclic (C.sub.3 -C.sub.10)-alkyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, phenyl, naphthyl, furyl, thienyl, benzoyl, substituted benzoyl, C.sub.2 -C.sub.4 -acyl, or a 5- or 6-membered monocyclic or 9- or 10-membered bicyclic heteroaryl group,wherein the heteroaryl group has 1 or 2 nitrogen atoms,wherein B is O, S, NH, NCN, NR.sub.6 or NOR.sub.6, andwherein R.sub.6 is C.sub.1 -C.sub.5 -alkyl,with the proviso that if X is CH.sub.2, then Q is not a group represented by the formula (III) or (IV).