Patent ID: 9023805
Filing Date: 2015-05-05
Classification: A61K,A61P

Abstract:
1. A method for increasing survival time in a patient with cancer who is or will be treated by the administration of one or more chemotherapeutic agents and/or additional related anti-neoplastic agents; wherein said cancer either: (i) overexpresses thioredoxin glutaredoxin and/or (ii) exhibits evidence of thioncdoxin-mediated or glutaredoxin-mediated resistance to the chemotherapy agent or agents used to treat said patient with cancer; wherein said thioredoxin or glutaredoxin overexpression and/or said thioredoxin-mediated or glutaredoxin-mediated treatment resistance is quantitatively determined by use of an analytical methodology selected from the group consisting of fluorescence in situ hybridization (FISH), nucleic acid microarray analysis, immunohistochemistry (IHC), and radioimmunoassay (RIA); wherein said method for increasing survival time in a patient with cancer comprises the administration of a medically-sufficient dose of 2-mercapto-ethane sulfonate which is conjugated as a disulfide with -Cys-Glu to said patient with cancer either prior to, concomitantly with, or subsequent to the administration of a chemotherapy agent or agents whose cytotoxic or cytostatic activity is adversely affected by either: (i) the overexpression of thioredoxin or glutaredoxin and/or (ii) thioredoxin-mediated or glutaredoxin-mediated treatment resistance; and wherein said method for increasing survival time in a patient with cancer may further comprise the administration of a medically-sufficient dose of one or more enzymes, proteins, peptides, small organic molecules, or polyclonal and/or monoclonal antibodies prior to, concomitantly with, or subsequent to the administration of said medically-sufficient dose of 2-mercapto-ethane sulfonate which is conjugated as a disulfide with -Cys-Glu.