Patent ID: 9127316
Filing Date: 2015-09-08
Classification: C12Q,G01N

Abstract:
1. A method of classifying a subject to a late onset Alzheimer's disease (LOAD) risk group, comprising: receiving a sample from the subject; detecting a first marker selected from the group consisting of rs10009946, rs1002261, rs10031360, rs10036338, rs10037238, rs10040520, rs10051640, rs10054011, rs10062543, rs10066153, rs10069118, rs10069190, rs10077548, rs10079121, rs1008055, rs1009940, rs1009947, rs1009987, rs10110144, rs10115578, rs10121466, rs10140673, rs10188267, rs10192963, rs10194172, rs10194269, rs1019670, rs10198042, rs10198317, rs10199416, rs1021632, rs10231253, rs1023964, rs10253781, rs1026254, rs1026255, rs10267678, rs1039147, rs10400909, rs1040211, rs10402271, rs10426094, rs10430148, rs10448254, rs10454797, rs10476994, rs10477463, rs10482042, rs10503040, rs10504376, rs10504377, rs10511964, rs10512156, rs10514883, rs10515026, rs10515029, rs10515386, rs10519170, rs1060455, rs10733121, rs10741175, rs10742719, rs10742722, rs10742725, rs10747215, rs10758596, rs10758597, rs10773829, rs10773890, rs10777410, rs10783282, rs10787629, rs1079022, rs10790519, rs10792084, rs10792267, rs10799801, rs10814235, rs1081900, rs10819162, rs10819173, rs10819174, rs10820403, rs10825816, rs10825817, rs10848219, rs10859338, rs10866514, rs10869422, rs10878636, rs10885864, rs10892873, rs10897003, rs10897020, rs10897049, rs10900908, rs10915495, rs10945913, rs10950253, rs10950254, rs10974449, rs10974859, rs10988348, rs11016132, rs1102617, rs11038193, rs11049049, rs11066247, rs11073964, rs11079804, rs1108209, rs11092309, rs11095608, rs11097396, rs1109916, rs11106228, rs11106700, rs1111218, rs11114028, rs11133030, rs11133248, rs11133602, rs11133822, rs11143837, rs11150971, rs11159907, rs11170973, rs11180553, rs11217627, rs11218016, rs11229192, rs11230180, rs1123024, rs11237698, rs11239751, rs11241620, rs1124165, rs1124166, rs11257695, rs11266413, rs1130371, rs1149736, rs1155098, rs11584403, rs1160985, rs11629688, rs11646101, rs11647759, rs11655913, rs11671804, rs11676819, rs11691971, rs11694165, rs11698059, rs11710973, rs11738432, rs11741205, rs11748700, rs11752453, rs11778430, rs1178520, rs11788891, rs1181913, rs1184766, rs11858967, rs11861905, rs11872966, rs11889938, rs11914999, rs11947861, rs11954932, rs12006950, rs12009590, rs1202525, rs12037204, rs12037869, rs1204331, rs12084240, rs12107500, rs12123186, rs12127313, rs12186632, rs12191684, rs12196957, rs12225299, rs12238307, rs12265862, rs12294703, rs12313149, rs12316258, rs12318549, rs12326462, rs1233078, rs12336107, rs12342299, rs12375106, rs12395571, rs12408105, rs12440774, rs12444393, rs12446552, rs12468287, rs12495316, rs12499442, rs12511743, rs12513052, rs12539316, rs12555462, rs1256424, rs1256428, rs1256444, rs1256447, rs12595616, rs12598082, rs12601300, rs12606449, rs12617390, rs12628020, rs12632665, rs12632797, rs12647148, rs12648659, rs12652190, rs12658719, rs12659288, rs12685147, rs12686342, rs12692593, rs12723357, rs12741415, rs12749061, rs1277307, rs12781952, rs12798784, rs12800777, rs12809801, rs12818087, rs12829992, rs1284059, rs12892914, rs12909713, rs12910825, rs12922082, rs12969851, rs13013898, rs13020250, rs13029092, rs13033552, rs13037545, rs13053558, rs13068144, rs13302146, rs13313001, rs1332249, rs13381188, rs13382950, rs13395944, rs13404031, rs13417560, rs1346440, rs1350089, rs1352576, rs1359651, rs1362729, rs1366413, rs1372254, rs1372567, rs1377334, rs1378169, rs1393360, rs1395773, rs1409427, rs1409428, rs1416770, rs1417032, rs1442063, rs1453013, rs1460191, rs1467737, rs1471994, rs1478281, rs1479560, rs1479831, rs1511556, rs1519812, rs1523314, rs1530914, rs1531347, rs1533822, rs1537989, rs1540125, rs1547329, rs1553497, rs1566106, rs1566430, rs158134, rs1582763, rs1596039, rs1604382, rs1618513, rs1634507, rs1634508, rs167602, rs16830888, rs16834130, rs16841583, rs16852038, rs16852953, rs16854702, rs1685513, rs16857593, rs16863859, rs16863867, rs16864008, rs16879230, rs16879693, rs16889006, rs16900667, rs16901211, rs16914456, rs16918465, rs16931253, rs16931257, rs16931273, rs16943700, rs16950383, rs16951392, rs16959238, rs16964797, rs16971511, rs16979301, rs16983551, rs16995332, rs17016207, rs17025061, rs17034079, rs17039828, rs17042395, rs17048072, rs17056952, rs17087898, rs17091212, rs17091253, rs17091265, rs17095426, rs17095429, rs17098400, rs17105491, rs17117632, rs17133758, rs17135372, rs17137349, rs17145817, rs1719141, rs1719210, rs1719220, rs17207648, rs17236661, rs17237607, rs17253937, rs17255138, rs17317101, rs17332633, rs17383755, rs17410182, rs17431, rs17465431, rs17488034, rs17494056, rs17498815, rs17522996, rs1752653, rs17594509, rs17598123, rs17599877, rs17600575, rs17602572, rs17643262, rs17650435, rs17654608, rs17711743, rs17712565, rs1772988, rs17734389, rs17771318, rs17773314, rs1778596, rs17797399, rs17835266, rs17835397, rs17865911, rs1798021, rs1805952, rs1805957, rs1805960, rs182174, rs1823667, rs1869620, rs1879818, rs1881441, rs1882569, rs1883487, rs1883488, rs1918676, rs1939184, rs1939194, rs1943229, rs1943783, rs1945390, rs1954850, rs1959185, rs1966374, rs1993471, rs1997608, rs2001217, rs2001517, rs200545, rs200547, rs2017823, rs2019707, rs2025466, rs202869, rs2031183, rs2033494, rs2034085, rs2040507, rs2042922, rs2043422, rs2057915, rs2058810, rs2059129, rs2062368, rs2081547, rs2090922, rs2110641, rs2110706, rs2127470, rs2131361, rs2136342, rs2136343, rs2139109, rs2139615, rs2152649, rs2160491, rs2166500, rs217034, rs2181987, rs2203432, rs2204608, rs2213369, rs2224182, rs2232313, rs2234246, rs2242945, rs2250392, rs2252238, rs2267346, rs227103, rs2273235, rs2277365, rs2278583, rs2286276, rs2288522, rs2289711, rs2304935, rs2317481, rs2346709, rs2356132, rs236573, rs2382492, rs2398485, rs2398671, rs2402961, rs2415025, rs2430373, rs2437801, rs2437803, rs2447265, rs2455787, rs2462645, rs2479505, rs2486027, rs2486866, rs2495988, rs2500144, rs2500153, rs2503285, rs252272, rs252950, rs252977, rs2541286, rs2544081, rs2577894, rs2593529, rs2594953, rs2603779, rs2612589, rs2612600, rs2624938, rs2635296, rs264256, rs2649627, rs2653322, rs2694814, rs2712590, rs2728524, rs275467, rs2809591, rs2812237, rs2819190, rs2827879, rs2827881, rs2827882, rs2827909, rs2827911, rs2833325, rs2834330, rs2834341, rs2834344, rs2837995, rs28515995, rs2856044, rs2879724, rs2880301, rs2881458, rs2881599, rs2885856, rs2898441, rs2899683, rs2900285, rs2901098, rs293540, rs293541, rs293542, rs293545, rs2954892, rs2956581, rs2960455, rs298069, rs298185, rs2997967, rs3019879, rs3104993, rs3104996, rs3112160, rs3118077, rs3120733, rs3127080, rs319855, rs319858, rs3208856, rs321325, rs32425, rs3323, rs34661737, rs35306465, rs35393495, rs35762589, rs35775016, rs371298, rs3745546, rs3755311, rs3768235, rs3777530, rs3781533, rs3786954, rs3790971, rs379717, rs3813097, rs3814127, rs3822459, rs3828191, rs3829304, rs3886569, rs3912944, rs3913840, rs394457, rs3960965, rs397118, rs40353, rs40665, rs40666, rs4072688, rs4090174, rs4097545, rs4113946, rs4121392, rs41323947, rs41381844, rs41390747, rs41407844, rs41437548, rs41447448, rs4147047, rs4233036, rs4237493, rs4241009, rs42495, rs4257715, rs4272222, rs4283782, rs4286782, rs4289558, rs4306376, rs4307374, rs4315367, rs4316805, rs4336923, rs4342343, rs4354335, rs4357331, rs4362707, rs4369216, rs4382847, rs4384677, rs4393536, rs4410671, rs4420638, rs4421130, rs4479297, rs4487976, rs4506675, rs4510072, rs4514520, rs4533297, rs4537793, rs4547126, rs4555926, rs4562978, rs456298, rs4576739, rs4639843, rs4643583, rs4648858, rs4648959, rs4652931, rs466093, rs4676320, rs4694116, rs4695895, rs4699882, rs4701641, rs4701734, rs4743641, rs4744768, rs4746100, rs4771531, rs4793734, rs4794225, rs4794346, rs4794347, rs4813394, rs4821990, rs4827479, rs4829946, rs4842993, rs4843267, rs4844600, rs4861498, rs4861864, rs4862558, rs4864737, rs4875330, rs4898337, rs4898872, rs4903240, rs4903243, rs4910821, rs4921744, rs492496, rs4938931, rs4953706, rs4955753, rs4956509, rs4961257, rs4961341, rs4964586, rs4972391, rs4975725, rs4978968, rs4978970, rs4984259, rs5015994, rs508915, rs541965, rs552409, rs558514, rs559664, rs562028, rs5756261, rs5758223, rs5758267, rs5763001, rs589605, rs5907046, rs5910606, rs5910607, rs5910608, rs5935673, rs5945088, rs5951325, rs5955490, rs5956359, rs5962536, rs5964670, rs5966049, rs5978287, rs5981380, rs5981711, rs5987025, rs5991907, rs5992600, rs6022638, rs6039654, rs6075709, rs6082159, rs6094509, rs610352, rs6123167, rs6137147, rs614013, rs617135, rs618499, rs622920, rs624761, rs627178, rs641118, rs642612, rs6430090, rs6451453, rs6458458, rs6473080, rs6479916, rs6498220, rs650943, rs6512077, rs6535872, rs6542225, rs6546889, rs6551575, rs655231, rs6552910, rs6555483, rs6557512, rs6562177, rs6569979, rs6577561, rs6577853, rs6591559, rs6594842, rs6603530, rs6603781, rs6621070, rs6631389, rs6632813, rs6636980, rs6654877, rs6658884, rs6675497, rs6677009, rs667897, rs6683441, rs6689572, rs670139, rs6705923, rs6706570, rs6709683, rs6716363, rs6724143, rs6726524, rs6729547, rs673281, rs6749325, rs676309, rs6770617, rs6796090, rs6800578, rs6800857, rs6817424, rs6828228, rs685859, rs6861510, rs6865969, rs6869793, rs687582, rs6903671, rs6914564, rs6966132, rs6983226, rs6997082, rs7001207, rs7018666, rs7018692, rs7018850, rs7026025, rs7031164, rs7031458, rs703374, rs7040120, rs7044778, rs7051342, rs7061770, rs7064361, rs7069106, rs7070647, rs7071432, rs7076076, rs7082405, rs7084466, rs7084673, rs7086393, rs7106518, rs7108663, rs7120207, rs7123220, rs713952, rs714235, rs7148564, rs7152695, rs7161372, rs7164426, rs717666, rs718376, rs7190355, rs7196364, rs7197825, rs7199809, rs7203844, rs7207413, rs7210605, rs7212136, rs7215182, rs7220146, rs7225545, rs7243684, rs7243917, rs7249558, rs7250661, rs7254358, rs7290458, rs7294982, rs7297136, rs7298828, rs7316571, rs7319447, rs7322229, rs7365975, rs738977, rs7423892, rs7495307, rs7499241, rs7517009, rs7517283, rs7532358, rs7535789, rs7577837, rs7579138, rs7580100, rs759112, rs7595401, rs7603548, rs7606424, rs7615639, rs7625628, rs7648664, rs7666693, rs7674035, rs7679858, rs7694032, rs7699718, rs7702491, rs7722665, rs7726558, rs7734932, rs7737490, rs7753479, rs7773435, rs7821916, rs7824527, rs7825534, rs783376, rs7846493, rs7849193, rs7856017, rs7868954, rs7869556, rs7871777, rs7872516, rs7876084, rs7878331, rs7895861, rs7896662, rs7908601, rs7947761, rs7955859, rs7998410, rs8006542, rs8014761, rs8015610, rs802441, rs802466, rs8042680, rs805530, rs805531, rs8057620, rs8070132, rs8082463, rs8082787, rs8110666, rs8112746, rs8129151, rs820255, rs824631, rs829465, rs829467, rs831480, rs846814, rs846818, rs846825, rs847386, rs848492, rs853389, rs853585, rs865671, rs880293, rs884771, rs890731, rs891088, rs914593, rs9267135, rs9285657, rs9291171, rs9309095, rs9324521, rs9329143, rs9332441, rs9351848, rs9369572, rs9374351, rs9375555, rs9376083, rs9378774, rs9390645, rs9394781, rs9395110, rs9405199, rs9424093, rs9427206, rs942950, rs943218, rs9434717, rs9435127, rs9472557, rs9485905, rs9494139, rs949973, rs950027, rs9504837, rs9520114, rs953362, rs953363, rs9544313, rs9555552, rs957979, rs958935, rs9635948, rs9651104, rs9651363, rs9652690, rs9652691, rs9654458, rs9706460, rs971354, rs9776031, rs9780606, rs9784631, rs9807618, rs980793, rs9812119, rs9812150, rs9842566, rs9872847, rs9889183, rs9896422, rs9898218, rs9899379, rs9904820, rs9909601, rs991110, rs9914336, rs9931815, rs9964709, rs999939, and rs9999758; detecting a second marker consisting of an E3 allele of APOE; classifying the subject into a risk group based upon the presence or absence of the markers; and wherein detection of the first marker is provided by a first probe and detection of the second marker is provided by a second probe, and further wherein the first probe and the second probe are affixed to a solid support of a microarray.