Patent ID: 9006283
Filing Date: 2015-04-14
Classification: A61K,A61P,C12N

Abstract:
1. A method for antagonizing neurotoxic ADDL formation from monomeric Aβ 1-42 by contacting monomeric Aβ 1-42 with an effective amount of a compound selected from the group consisting of N-(2-Methoxy-phenyl)-2-oxo-2-{N′-[3-oxo-3-thiophen-2-yl-1-trifluoromethyl-prop-(Z)-ylidene]-hydrazino}-acetamide, 2-{[1-(2-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester, 2-{[1-(2-Hydroxynaphthalen-1-yl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester, 2-{[1-(2-Hydroxyphenyl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester, 2-(5-hydroxy-3-isobutyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-N-(2-methoxyphenyl)-2-oxoacetamide, (E)-2-hydroxy-N′-((1-hydroxynaphthalen-2-yl)methylene)benzohydrazide, or a stereoisomer thereof or a mixture of the stereoisomers, or a pharmaceutical salt of the compound, stereoisomer or mixture.