Patent ID: 6096887
Filing Date: 2000-08-01
Classification: C07D

Abstract:
A compound of the formula: ##STR61## or the pharmaceutically acceptable non-toxic salts thereof wherein: n is 1 or 2;T is halogen, hydrogen, hydroxy, nitro, amino or straight or branched chain lower alkoxy having 1-6 carbon atoms;X is hydrogen, hydroxyl or straight or branched chain lower alkyl having 1-6 carbon atoms;W is naphthyridinyl, thienyl, 2-quinolinyl, 3-quinolinyl or pyridinyl, each of which is optionally mono or multi-substituted independently with halogen, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms or cycloalkyl having 3-7 carbon atoms, amino, mono or dialkylamino where each alkyl is independently straight or branched chain lower alkyl having 1-6 carbon atoms or cycloalkyl having 3-7 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms, cycloalkyl alkoxy having 3-7 carbon atoms, or NR.sub.1 COR.sub.2, COR.sub.2, CONR.sub.1 R.sub.2 or CO.sub.2 R.sub.2 where R.sub.1 and R.sub.2 are the same or different and represent hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms or cycloaklyl having 3-7 carbon atoms; andR.sub.8 is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms; andR.sub.9 is --COR.sub.13, --CO.sub.2 R.sub.13 or --R.sub.13, where R.sub.13 is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; orR.sub.9 is --CONR.sub.14 R.sub.15 or --(CH.sub.2).sub.k NR.sub.14 R.sub.15, where k is 0, 1, or 2; R.sub.14 represents hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms; and R.sub.15 is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or 2-, 3- or 4-pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; or NR.sub.14 R.sub.15 forms a heterocyclic group which is morpholyl, piperidyl, pyrrolidyl, or N-alkyl piperazyl.