Patent ID: 6251948
Filing Date: 2001-06-26
Classification: A61K,A61P,B41J,C07C,C07D,G03G

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a guanidine having the formula: ##STR4##wherein R' is a C.sub.1 -C.sub.7 alkyl group, a C.sub.2 -C.sub.6 alkenyl group, a C.sub.2 -C.sub.6 alkynyl group, a cycloalkyl group, cycloalkyl substituted by one or more substituents, a cycloalkenyl group, cycloalkenyl substituted by one or more substituents, carbocyclic group, alkaryl group, or an alkaryl group substituted by one or more substituents, aralkyl group, aralkyl group substituted by one or more substituents, heterocyclic group, heterocyclic group substituted by one or more substituents, heteroaryl group, or a heteroaryl group substituted by one or more substituents;R and R"" are each independently a carbocyclic aryl group, carbocyclic aryl group substituted by one or more substituents, alkaryl group, or an alkaryl group substituted by one or more substituents, heterocyclic group, heterocyclic group substituted by one or more substituents, heteroaryl group, or a heteroaryl group substituted by one or more substituents;or a physiologically acceptable salt thereof;wherein said substituent is chloro, fluoro, bromo, iodo, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, cyano, C.sub.3 -C.sub.15 dialkylaminoalkyl, carboxy, carboxamido, C.sub.1 -C.sub.8 alkylthio, allyl, aralkyl, alkaryl, C.sub.3 -C.sub.6 cycloalkyl, aroyl, aralkoxy, C.sub.2 -C.sub.8 acyl, aryl, heteroaryl, a carbocyclic aryl fused to a benzene ring, a heteroaryl fused to a benzene ring, C.sub.3 -C.sub.6 heterocycloalkyl, a C.sub.3 -C.sub.6 heterocycloalkyl ring fused to a benzene ring, C.sub.1 -C.sub.8 alkylsulfonyl, arylthio, amino, C.sub.1 -C.sub.8 alkylamino, C.sub.2 -C.sub.15 dialkylamino, hydroxy, hydroxyalkyl, carbamoyl, C.sub.1 -C.sub.6 N-alkylcarbamoyl, C.sub.2 -C.sub.15 N,N-dialkylcarbamoyl, nitro, azido or C.sub.2 -C.sub.15 dialkylsulfamoyl, with the exclusion of N,N'-bisphenyl-N-ethylguanidine.