Patent ID: 9175022
Filing Date: 2015-11-03
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A method of treating leukemia, sarcoma, melanoma, or breast carcinoma, in a subject, comprising administering to the subject an effective amount of a compound represented by formula (VIIA): or a pharmaceutically acceptable salt thereof, wherein: one of R Ring E is substituted with one or more substituents independently selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkoxy, an optionally substituted alkylsulfanyl, an optionally substituted alkylamino, an optionally substituted dialkylamino, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, an optionally substituted haloalkyl, C (O) NR R R is a side chain of a naturally-occurring amino acid; an optionally substituted alkyl group, an optionally substituted heteroalkyl group, an optionally substituted aromatic group, or an optionally substituted heteroaromatic group; R R R R R R Y is CH R Alk is an optionally substituted alkylene; Het is an optionally substituted heteroalkyl; Y n is 1, 2, 3, or 4; m is an integer from 1 to 10; and q is 0 or 1.