Patent ID: 7666855
Filing Date: 2010-02-23
Classification: A61P,C07H

Abstract:
1. A compound of Formula II: wherein: B is selected from the group consisting of V is selected from the group consisting of optionally substituted monocyclic aryl and unsubstituted or substituted monocyclic heteroaryl wherein said substituted monocyclic aryl and said substituted monocyclic heteroaryl are substituted with 1-6 substituents selected from the group consisting of lower alkyl, lower alkoxy, lower perhaloalkyl, halogen, hydroxy, cyano, amino, —OR W and W′ are independently selected from the group consisting of —H, methyl, and V, or W and W′ are each methyl, with the proviso that when W is V, then W′ is H; Z is selected from the group consisting of —H, —OMe, —OEt, phenyl, C together V and Z are connected via an additional 3-5 atoms to form a cyclic group, containing 0-1 heteroatom, that is fused to an aryl group at the beta and gamma position to the O attached to the phosphorus; or together Z and W are connected via an additional 3-5 atoms to form a cyclic group, containing 0-1 heteroatom; or together W and W′ are connected via an additional 2-5 atoms to form a cyclic group; R R R R R together R R or a pharmaceutically acceptable salt thereof.