Patent ID: 6689890
Filing Date: 2004-02-10
Classification: C07D,C40B

Abstract:
A method of synthesizing a structure compound of formula (II) said method comprising:providing a compound of formula (I), in which:R1, R4, R5, and R6, are independently H, halo, N3, CN, NC, (C1-C22)alkyl, (C6-C10)aryl, (C3-C8)cycloalkyl, (C7-C32)aralkyl, (C7-C32)alkylaryl, OR, SR, N(R)2, CO2R, C(O)R, P(O)(OR)2, COR, CF3, S(O)R, or SO2R, wherein each R is independently H, (C1-C22)alkyl, (C6-C10)aryl, (C3-C8)cycloalkyl, (C2-C22)alkenyl, (C5-C8)cycloalkenyl, (C7-C32)aralkyl, (C7-C32)alkylaryl, C9-C32)aralkenyl, or (C9-C32)alkenylaryl, and R2 and R3 together comprise â€”C(CH3)2â€”Oâ€”CH2â€”, â€”(CH2)nâ€”Oâ€”C(O)â€”, or â€”C(X)â€”Oâ€”CH2â€” where n=0-10, and X is (C6-C10)aryl or (C7-C32)alkylaryl; or R2 and R3 are independently H, halo, N3, CN, NC, (C1-C22)alkyl, (C6-C10)aryl, (C3-C8)cycloalkyl, (C2-C22)alkenyl, (C5-C8)cycloalkenyl, (C7-C32)aralkyl, (C7-C32)alkylaryl, (C9-C32)aralkenyl, (C9-C32)alkenylaryl, OR, SR, N(R)2, NH(R), CO2R, C(O)R, P(O)(OR)2, COR, CF3, S(O)R, or SO2R, wherein each R is independently H, (C1-C22)alkyl, (C6-C10)aryl, (C3-C8)cycloalkyl, (C2-C22)alkenyl, (C5-C8)cycloalkenyl, (C7-C32)aralkyl, (C7-C32)alkylaryl, (C9-C32)aralkenyl, or (C9-C32)alkenylaryl; and reacting said compound of formula (I) under conditions promoting intramolecular Câ€”H insertion, whereby said lactam or said pyrrolidinone precursor compound of formula (II) is synthesized.