Patent ID: 6545036
Filing Date: 2003-04-08
Classification: A61K,A61P,Y10S

Abstract:
A method for treating ocular hypertension or glaucoma comprising administration to a patient in need of such treatment a therapeutically effective amount of a compound of structural formula I: or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof: wherein,R1 represents hydrogen or C1-6 alkyl; R2, R3a and R3b independently represent hydrogen, alkylsilyl, C1-10 alkyl, C3-10 cycloalkyl, C4-10 heterocycloalkyl, C4-10 heteroaryl, NH2, or C6-10 aryl said alkyl, aryl or heteraryl optionally substituted with 1-3 groups of Rx; Rx represents C1-6 alkyl, halogen, CF3, C1-6 alkoxy, NR1R1, or NO2, or NH2; R4 represents hydrogen, C1-6 alkoxy, C1-6 alkyl, CF3, or halogen; R5 represents hydrogen, C1-6 alkoxy, C1-6 alkyl, CF3, nitro, amino, cyano, C1-6 alkylamino, or halogen and R6 represents hydrogen, halogen or C1-6 alkyl.