Patent ID: 6350741
Filing Date: 2002-02-26
Classification: A61K,A61P,C07K,Y02A

Abstract:
A compound represented by a formula (III): whereinY is: provided that when R5 is â€”OH then Y can also be m is 0 or 1; Z is â€”CH2â€”, â€”C(O)â€”, or â€”C(&boxH;Nâ€”OR21)â€”; C is benzo, wherein the ring is optionally singly or multiply substituted with â€”R4; R1 is -aryl, -heteroaryl, -alkylaryl, or -alkylheteroaryl, wherein each -aryl or -heteroaryl is optionally singly or multiply substituted with R17; R2 is a bond, â€”C(O)â€”, â€”C(O)C(O)â€”, â€”S(O)2â€”, â€”OC(O)â€”, â€”N(H)C(O)â€”, â€”N(H)S(O)2â€”, â€”N(H)C(O)C(O)â€”, â€”CH&boxH;CHC(O)â€”, â€”OCH2C(O)â€”, â€”N(H)CH2C(O)â€”, â€”N(R19)C(O)â€”, â€”N(R19)S(O)2â€”, â€”N(R19)C(O)C(O)â€”, or â€”N(R19)CH2C(O)â€”; R4 is â€”OH, â€”F, â€”Cl, â€”Br, â€”I, â€”NO2, â€”CN, â€”NH2, â€”CO2H, â€”C(O)NH2, â€”N(H)C(O)H, â€”N(H)C(O)NH2, -alkyl, -cycloalkyl, -perfluoroalkyl, â€”O-alkyl, â€”N(H)alkyl, â€”N(alkyl)2, â€”C(O)N(H)alkyl, â€”CON(alkyl)2, â€”N(H)C(O)alkyl, â€”N(H)C(O)N(H)alkyl, â€”N(H)C(O)N(alkyl)2, â€”S-alkyl, â€”S(O)2alkyl, â€”C(O)alkyl, â€”CH2NH2, â€”CH2N(H)alkyl, or â€”CH2N(alkyl)2; R5 is â€”OH, â€”OR8, or â€”N(H)OH; R6 is â€”H, â€”CH2OR9, â€”CH2SR10, â€”CH2N(H)R9, â€”CH2N(R9)R12, â€”CHN2, â€”CH2F, â€”CH2Cl, â€”C(O)N(R11)R12, â€”R13, or â€”R14; R8 is -alkyl, -cycloalkyl, -aryl, -heteroaryl, -alkylaryl, -alkylheteroaryl, or -alkylheterocycle; R9 is â€”H, â€”COaryl, â€”COheteroaryl, â€”COalkylaryl, â€”COalkylheteroaryl, -alkylaryl, -alkylheteroaryl, -aryl, -heteroaryl, or â€”P(O)R15R16; R10 is -alkylaryl or -alkylheteroaryl; R11 and R12 are independently â€”H, -alkyl, -aryl, -heteroaryl, -cycloalkyl, -alkylaryl, or -alkylheteroaryl; R13 is -alkylaryl or -alkylheteroaryl; R14 is wherein (i) is optionally substituted with one or more â€”R17 and (ii) is optionally substituted with one or more â€”R17, â€”R18 or â€”R20; X is O or S; R15 and R16 are independently â€”H, â€”OH, -alkyl, -aryl, -heteroaryl, -cycloalkyl, -alkylaryl, -alkylheteroaryl, â€”Oalkyl, â€”Oaryl, â€”Oheteroaryl, â€”Oalkylaryl, or â€”Oalkylheteroaryl; R17 is â€”OH, â€”F, â€”Cl, â€”Br, â€”I, â€”NO2, â€”CN, â€”NH2, â€”CO2H, â€”C(O)NH2, â€”N(H)C(O)H, â€”N(H)C(O)NH2, â€”S(O)2NH2, â€”C(O)H, -alkyl, -cycloalkyl, -perfluoroalkyl, â€”O-alkyl, â€”N(H)alkyl, â€”N(alkyl)2, â€”CO2alkyl, â€”C(O)N(H)alkyl, â€”C(O)N(alkyl)2, â€”N(H)C(O)alkyl, â€”N(H)C(O)N(H)alkyl, â€”N(H)C(O)N(alkyl)2, â€”S(O)2N(H)alkyl, â€”S(O)2N(alkyl)2, â€”S-alkyl, â€”S(O)2alkyl, or â€”C(O)alkyl; R18 is -aryl, -heteroaryl, -alkylaryl, -alkylheteroaryl, â€”O-aryl, â€”O-heteroaryl, â€”O-alkylaryl, â€”O-alkylheteroaryl, â€”N(H)aryl, â€”N(aryl)2, â€”N(H)heteroaryl, â€”N(heteroaryl)2, â€”N(H)alkylaryl, â€”N(alkylaryl)2, â€”N(H)alkylheteroaryl, â€”N(alkylheteroaryl)2, â€”S-aryl, â€”S-heteroaryl, â€”S-alkylaryl, â€”S-alkylheteroaryl, â€”C(O)aryl, â€”C(O)heteroaryl, â€”C(O)alkylaryl, â€”C(O)alkylheteroaryl, â€”CO2aryl, â€”CO2heteroaryl, â€”CO2alkylaryl, â€”CO2alkylheteroaryl, â€”C(O)N(H)aryl, â€”C(O)N(aryl)2, â€”C(O)N(H)heteroaryl, â€”C(O)N(heteroaryl)2, â€”C(O)N(H)alkylaryl, â€”C(O)N(alkylaryl)2, â€”C(O)N(H)alkylheteroaryl, â€”C(O)N(alkylheteroaryl)2, â€”S(O)2-aryl, â€”S(O)2-heteroaryl, â€”S(O)2-alkylaryl, â€”S(O)2-alkylheteroaryl, â€”S(O)2N(H)-aryl, â€”S(O)2N(H)-heteroaryl, â€”S(O)2N(H)-alkylaryl, â€”S(O)2N(H)-alkylheteroaryl, â€”SO2N(aryl)2, â€”SO2N(heteroaryl)2, â€”SO2N(alkylaryl)2, â€”SO2N(alkylheteroaryl)2, â€”N(H)C(O)N(H)aryl, â€”N(H)C(O)N(H)heteroaryl, â€”N(H)C(O)N(H)alkylaryl, â€”N(H)C(O)N(H)alkylheteroaryl, â€”N(H)C(O)N(aryl)2, â€”N(H)C(O)N(heteroaryl)2, N(H)C(O)N(alkylaryl)2, or â€”N(H)C(O)N(alkylheteroaryl)2; R19 is â€”H, -alkyl, -cycloalkyl, -aryl, -heteroaryl, -alkylaryl, or -alkylheteroaryl, or -alkylheterocycle; R20 is -alkyl-R18; and R21 is H, alkyl, alkylaryl, or -alkylheteroaryl.