Patent ID: 6670394
Filing Date: 2003-12-30
Classification: A61K,A61P,Y10S

Abstract:
A method for the prophylaxis of or for treating COPD in a human by administering to a patient in need thereof a PDE 4-specific inhibitor which preferentially inhibits the PDE 4 catalytic form that binds R-rolipram with a low affinity, which method comprises administering to a subject in need thereof an effective amount of a compound having an IC50 ratio of about 0.1 or greater as regards the IC50 for a PDE 4 form which binds R-rolipram with a high affinity divided by the IC50 for the catalytic form which binds R-rolipram with a low affinity, excluding cis-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexan-1-carboxylate].