Patent ID: 6979561
Filing Date: 2005-12-27
Classification: C12P

Abstract:
1. A process for the resolution of a compound of Formula A: wherein: X=F; Y=S; wherein the process comprises the steps of: (a) dispersing an enantiomeric mixture of a compound of Formula B wherein: R is C X=F; Y=S at a concentration of between about 5% and about 45% (weight/volume of a non-homogeneous system), in an organic solvent system to produce an organic component; (b) providing an aqueous solvent system to produce an aqueous component; and (c) contacting the organic component and the aqueous component to form a non-homogeneous system, under conditions which permit the resolution of the mixture with a hydrolase enzyme to produce a chiral non-racemic ester of Formula B and a non-racemic alcohol of Formula A