Patent ID: 7741490
Filing Date: 2010-06-22
Classification: C07D

Abstract:
1. A process for the preparation of pramipexole, or a pharmaceutically acceptable salt thereof, comprising the acylation of a compound of formula (VII), either as the single (S) enantiomer or as mixture of (R,S) enantiomers wherein R3 is hydrogen and Ra is a free or protected amino group, by reaction with propionic anhydride, and subsequent reduction of the resulting compound of formula (IX) wherein Ra is as defined above, by treatment with an alkali metal borohydride and molecular iodine, to obtain a compound of formula (VIII) wherein R followed, if necessary, by deprotection of the primary amino group and/or by resolution of the mixture of (R,S) enantiomers into the single (S) enantiomer and, if desired, by conversion of pramipexole to a pharmaceutically acceptable salt thereof.