Patent ID: 8932715
Filing Date: 2015-01-13
Classification: A61K,C07K,Y10T

Abstract:
1. A suspension of particles in a polar organic solvent comprising less than 25% water, wherein the particles comprise at least one bioactive molecule, wherein the particles have been prepared by precipitation of said bioactive molecule(s) from an aqueous composition comprising said bioactive molecule(s) and at least one cationic and at least one anionic precipitation stabilizing additives-, upon mixing with a greater than 3-fold excess of a polar organic solvent, wherein the resulting precipitated particles further comprise said precipitation stabilizing additive(s); wherein said bioactive molecule(s) is an aggregation-sensitive biomolecule(s); and wherein the percentage of said bioactive molecules exhibiting a changed aggregation state from the aggregation state present prior to precipitation of said particles is less than 5%.