Patent ID: 9187526
Filing Date: 2015-11-17
Classification: A61K,A61P,C07K

Abstract:
1. A therapeutic composition for reducing cellular proliferation of malignant cells that express a cancer specific isoform of proliferating cell nuclear antigen (caPCNA), the composition comprising a peptide molecule selected from the group consisting of: a) peptide consisting of the amino acid sequence LGIPEQEY (SEQ ID No. 1) and b) peptide comprising the amino acid sequence LGIPEQEY (SEQ ID No. 1) and up to three additional amino acids on the NH2 terminus of LGIPEQEY (SEQ ID No. 1) or up to nine amino acids on the —COOH terminus of LGIPEQEY (SEQ ID No. 1); wherein the therapeutic composition further comprises a cell-permeable peptide.