Patent ID: 6313153
Filing Date: 2001-11-06
Classification: C07D

Abstract:
A method for treating nephritis comprising(a) providing pharmaceutical composition comprising a pyridylacrylamide compound represented by the following formula (I): ##STR175##wherein Ar.sup.1 is a substituted or unsubstituted pyridyl group, Ar.sup.2 is a substituted or unsubstituted phenyl group, R.sup.1 is a hydrogen atom, a C.sub.1-6 alkyl group or an aryl group, R.sup.2 is a hydrogen atom, a C.sub.1-6 alkyl group, a cyano group or a C.sub.1-6 alkoxy-carbonyl group, R.sup.3 is a hydrogen atom or an optionally substituted C.sub.1-6 alkyl group, X is an oxygen or sulfur atom, A and B are same or different and each represent a hydrogen atom, a hydroxyl group, a C.sub.1-6 alkoxy group or a C.sub.1-6 alkylthio group, or A and B together form an oxo or thioxo group, or a group represented by the formula: .dbd.N--Y in which Y is a di(C.sub.1-6 alkyl)amino, hydroxyl, aralkyloxy or C.sub.1-6 alkoxy group, or a group represented by the formula: --Z.sup.1 --M--Z.sup.2 -- in which Z.sup.1 and Z.sup.2 are same or different and each represent an oxygen or sulfur atom or an imino group optionally substituted by a C.sub.1-6 alkyl group, and M is an alkylene group having 2 to 4 chain members or a 1,2-phenylene group, or A is a hydroxyl group and B is a 1-C.sub.1-6 alkyl-imidazol-2-yl group, and n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof; and,(b) administering the pharmaceutical composition in a pharmaceutically effective amount, thereby treating the nephritis.