Patent ID: 6521264
Filing Date: 2003-02-18
Classification: A61F,A61K,A61L,C01B,C04B

Abstract:
A process for the preparation of a biomaterial comprising a hardening phase at a utilization site, in which calcium phosphates are mixed to obtain a hydroxy apatite with an atomic ratio Ca/P of between 1.50 and 1.67, the process comprising the steps of:(a) mixing a tricalcium phosphate powder and a tetracalcium phosphate powder to obtain a solid pulverulent product having an atomic ratio Ca/P of between 1.40 and 1.90; (b) preparing an aqueous solution or solutions containing calcium ions and phosphate ions having an overall atomic ratio Ca/P of the solutions greater than 0.20 and the atomic ratio Ca/P of each solution less than 0.50; and (c) mixing the aqueous solution or solutions, the solid pulverulent product and optionally water to obtain a final mixture with a liquid/solid weight ratio of between 0.30 and 0.65 so as to obtain a homogeneous paste of an atomic ratio Ca/P of between 1.50 and 1.67, the paste being emplaced at the utilization site for in situ hardening.