Patent ID: 6383487
Filing Date: 2002-05-07
Classification: A61K,A61P,C07K

Abstract:
A method of treating lymphomas or T-cell leukemias in a patient in need of such treatment comprising administering to the patient an effective amount of a conjugate of a CD25 binding molecule and an enzyme, toxin or radioisotope, which CD25 binding molecule comprises:at least one antigen binding site comprising at least one domain which comprises in sequence hypervariable regions CDR1, CDR2 and CDR3, said hypervariable regions alternating with framework regions, wherein said CDR1 comprises the amino acid sequence in SEQ. ID. NO: 7, said CDR2 comprises the amino acid sequence in SEQ. ID. NO: 8 and said CDR3 comprises the amino acid sequence in SEQ. ID. NO: 9; or said CDR1, COR2 and CDR3 taken in sequence as a whole comprise an amino acid sequence which is at least 90% identical to SEQ. ID. NOs: 7, 8 and 9 taken in sequence as a whole.