Patent ID: 9090573
Filing Date: 2015-07-28
Classification: A61K,A61P,C07D

Abstract:
1. A compound, selected from the group consisting of: 4′-[3-Methyl-4-(3-phenyl-propionylamino)-isoxazol-5-yl]-biphenyl-3-carboxylic acid (Compound 1-1); 4′-[4-(3-Benzyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-3-carboxylic acid (Compound 1-2); 1-{4′-[3-Methyl-4-(3-methyl-butyrylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-3); 1-{4′-[3-Methyl-4-(3-phenyl-propionylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-4); 1-{4′-[3-Methyl-4-(2-phenoxy-acetylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-5); 1-{4′-[4-(3-Benzyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-6); 1-{4′-[4-(3-tert-Butyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-7); 1-{4′-[4-(3-Isopropyl-3-methyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-4- -yl}-cyclopropanecarboxylic acid (Compound 1-8); 1-(4′-{3-Methyl-4-[3-methyl-3-((R)-1-phenyl-ethyl)-ureido]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-9); 1-(4′-{3-Methyl-4-[3-((R)-1-phenyl-ethyl)-ureido]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-11); 1-(4′-{4-[3-(2-Fluoro-benzyl)-ureido]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-12); 1-(4′-{3-Methyl-4-[3-(2,2,2-trifluoro-ethyl)-ureido]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-13); 1-{4′-[4-(2-Chloro-phenylmethanesulfonylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-14); 1-(4′-{4-[3-(2-Fluoro-5-trifluoromethyl-benzyl)-ureido]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-15); 1-(4′-{4-[3-(2,6-Difluoro-benzyl)-ureido]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-16); 1-{4′-[3-Methyl-4-(2-phenoxy-propionylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-17); 1-{4′-[4-(3-Benzenesulfonyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-18); 1-{4′-[3-Methyl-4-((R)-1-phenyl-ethylcarbamoyloxymethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-19); 1-[4′-(4-Benzylcarbamoyloxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]cyclopropanecarboxylic acid (Compound 1-21); 1-{4′-[3-Methyl-4-((S)-1-phenyl-ethylcarbamoyloxymethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-22); 1-[4′-(4-Cyclopentylcarbamoyloxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-23); 1-(4′-{4-[(Cyclopropylmethyl-amino)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-27); 1-(4′-{4-[(Cyclohexylmethyl-amino)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-28); 1-{4′-[4-(Benzylamino-methyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-29); 1-(4′-{4-[(Acetyl-phenethyl-amino)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-30); 1-{4′-[3-Methyl-4-(4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-31); 1-(4′-{3-Methyl-4-[(1-phenyl-ethylcarbamoyl)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-33); 1-{4′-[4-(2-Cyclopropylmethoxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-35); 1-{4′-[4-(2-Benzoylamino-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-36); 1-{4′-[4-(2-Dibenzylamino-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-37); 1-[4′-(3-Methyl-4-phenethylcarbamoyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-38); 1-{4′-[4-(2-Cyclopropylcarbamoyl-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-39); 1-(4′-{4-[2-(Cyclopropylmethyl-carbamoyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-40); 1-{4′-[3-Methyl-4-(3-oxo-3-pyrrolidin-1-yl-propyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-41); 1-{4′-[4-(2-Benzylcarbamoyl-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-42); 1-{4′-[3-Methyl-4-(2-phenylcarbamoyl-ethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-43); 1-[4′-(4-{2-[(2-Fluoro-benzyl)-methyl-carbamoyl]-ethyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-44); 1-[4′-(4-Benzyloxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-45); 1-{4′-[4-(2-Chloro-benzyloxymethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-46); 1-{4′-[3-Methyl-4-(1-phenyl-ethoxymethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-47); 1-[4′-(4-Benzylsulfanylmethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-50); 1-[4′-(3-Methyl-4-phenylmethanesulfinylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-52); 1-[4′-(3-Methyl-4-phenylmethanesulfonylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-53); 1-{4′-[3-Methyl-4-(2-phenyl-ethanesulfinylmethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-54); 1-{4′-[3-Methyl-4-(2-phenyl-ethanesulfonylmethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-55); 1-{4′-[4-(Benzyloxycarbonylamino-methyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-57); 1-{4′-[3-Methyl-4-(phenylacetylamino-methyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-58); 1-{4′-[4-(3-Benzyl-ureidomethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-59); 1-(4′-{3-Methyl-4-[(3-phenyl-propionylamino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-60); 1-(4′-{4-[(2-Chloro-phenylmethanesulfonylamino)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-61); 1-{4′-[3-Methyl-4-((Z)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-2-yl}-cyclopropanecarboxylic acid (Compound 1-62); 1-{4′-[3-Methyl-4-((E)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-2-yl}-cyclopropanecarboxylic acid (Compound 1-63); 1-[4′-(3-Methyl-4-{[(1-phenyl-cyclopropanecarbonyl)-amino]-methyl}-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-64); 1-{4′-[4-(Indan-1-ylcarbamoylmethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-65); 1-(4′-{4-[2-(1,3-Dihydro-isoindol-2-yl)-2-oxo-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-66); 1-(4′-{3-Methyl-4-[(methyl-phenethyl-amino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-67); 1-[4′-(4-{[Acetyl-(2-phenyl-propyl)-amino]-methyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-70); 1-(4′-{3-Methyl-4-[(methyl-phenylacetyl-amino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-71); 1-[4′-(3-Methyl-4-{[methyl-(2-phenoxy-propionyl)-amino]-methyl}-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-72); 1-[4′-(4-{[Cyclopropanecarbonyl-(2-phenyl-propyl)-amino]-methyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-73); 1-[4′-(4-{[Benzoyl-(2-phenyl-propyl)-amino]-methyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-74); 1-(4′-{3-Methyl-4-[2-(pyridin-2-ylmethoxy)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-75); 1-(4′-{3-Methyl-4-[2-(pyridin-3-ylmethoxy)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-76); 1-(4′-{3-Methyl-4-[2-(pyridin-4-ylmethoxy)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-77); 1-(4′-{3-Methyl-4-[2-(methyl-phenyl-carbamoyl)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-82); 1-{4′-[3-Methyl-4-(2-phenylmethanesulfinyl-ethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-84); 1-{4′-[3-Methyl-4-(2-phenylmethanesulfonyl-ethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-85); 1-[4′-(3-Methyl-4-{[methyl-(2-phenyl-propyl)-amino]-methyl}-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-87); 1-{4′-[3-Methyl-4-(2-oxo-4-phenyl-butyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-88); 1-{4′-[4-(Indan-2-ylcarbamoylmethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-90); 1-[4′-(4-{[(2-Fluoro-benzyl)-methyl-carbamoyl]-methyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-91); 1-(4′-{4-[((1S,2R)-2-Hydroxy-indan-1-ylcarbamoyl)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-92); 1-{4′-[3-Methyl-4-((Z)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-94); 1-{4′-[3-Methyl-4-((E)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-95); 1-[4′-(4-Isobutylsulfanylmethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-96); 1-(4′-{3-Methyl-4-[1-(1-phenyl-ethylcarbamoyl)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-97); 1-(4′-{3-Methyl-4-[(2-methyl-2-phenyl-propionylamino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-98); 1-{4′-[4-((S)-Indan-1-ylcarbamoylmethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-99); 1-(4′-{3-Methyl-4-[(2-phenoxy-propionylamino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-100); (1-{4′-[3-Methyl-4-((Z)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-101); (1-{4′-[3-Methyl-4-((E)-4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-102); 1-[4′-(4-{[Ethyl-((R)-2-phenyl-propyl)-amino]-methyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-104); 1-[4′-(3-Methyl-4-{2-[(R)-methyl-(1-phenyl-ethyl)-carbamoyl]-ethyl}-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-105); 1-(4′-{3-Methyl-4-[2-(1-methyl-1-phenyl-ethylcarbamoyl)-ethyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-106); 1-(4′-{4-[3-(1,3-Dihydro-isoindol-2-yl)-3-oxo-propyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-107); [4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-acetic acid (Compound 1-108); {4′-[3-Methyl-4-(2-phenyl-ethanesulfonylmethyl)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid (Compound 1-109); 1-{4′-[3-Methyl-4-(4-phenyl-pent-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-110); 1-(4′-{4-[4-(4-Isopropyl-phenyl)-3-methyl-but-1-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-111); 1-{4′-[3-Methyl-4-((Z)-4-phenyl-pent-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-112); 1-{4′-[3-Methyl-4-((E)-4-phenyl-pent-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-113); 1-{4′-[4-((E)-1-Hydroxy-4-phenyl-but-3-enyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-115); 1-(4′-{4-[2-(Cyclopropylmethyl-methyl-carbamoyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-117); 1-[4′-(3-Methyl-4-{2-[methyl-(1-methyl-1-phenyl-ethyl)-carbamoyl]-ethyl}-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-118); 1-(4′-{4-[2-(Cyclopropylmethyl-methyl-carbamoyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-119); 1-{4′-[3-Methyl-4-(2-oxo-2-phenyl-ethylsulfanylmethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-120); 2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-butyric acid (Compound 1-122); 2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid (Compound 1-123); 1-{4′-[3-Methyl-4-(4-phenyl-butyryl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-124); {1-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid (Compound 1-125); 1-(4′-{4-[2-(Cyclopropyl-methyl-carbamoyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-127); (trans)-2-{4′-[3-Methyl-4-(4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-128); (cis)-2-{4′-[3-Methyl-4-(4-phenyl-but-1-enyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-129); (trans)-2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-130); (cis)-2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-131); 2-Methyl-2-[4′-(3-methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid (Compound 1-133); 1-[4′-(4-{2-[Hydroxyimino]-4-phenyl-butyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-134); (1R,2S)-2-{4′-[4-(2,2-Difluoro-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-135); 2-{4′-[4-(2,2-Difluoro-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid (Compound 1-136); 3-Methyl-2-[4′-(3-methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-butyric acid (Compound 1-137); 1-(4′-{4-[3-(Acetyl-benzyl-amino)-2-hydroxy-propyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-138); 1-(4′-{4-[3-(Benzyl-methanesulfonyl-amino)-propenyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-139); (1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-140); 1-(4′-{4-[2-(Acetyl-benzyl-amino)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-142); 1-(4′-{4-[2-(Benzyl-methanesulfonyl-amino)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-143); (cis)-2-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-144); 2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-3-phenyl-propionic acid (Compound 1-145); 1-{4′-[4-(1-Ethoxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-147); 1-{4′-[4-(1-Methoxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-148); (cis)-2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Enantiomer A) (Compound 1-149); (cis)-2-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Enantiomer B) (Compound 1-150); 1-{4′-[4-(3,3-Dimethyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-151); 1-[4′-(4-Hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (Compound 1-152); 1-{4′-[3-Methyl-4-(3-phenyl-propionyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-157); 1-{4′-[4-((E)-1-Hydroxy-3-phenyl-allyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-158); 1-(4′-{3-Methyl-4-[3-(3-trifluoromethyl-phenyl)-propionyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-160); 1-(4′-{4-[(E)-1-Hydroxy-3-(3-trifluoromethyl-phenyl)-allyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-161); (4′-{4-[3-(3-Fluoro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}- -biphenyl-4-yl)-acetic acid (Compound 1-165); 1-{4′-[4-(1-Hydroxy-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-166); {4′-[4-(2,2-Difluoro-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-y-1}-acetic acid (Compound 1-170); 2-(4′-{4-[1-Hydroxy-4-(2-trifluoromethyl-phenyl)-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-butyric acid (Compound 1-171); {4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid (Compound 1-174); (1-{4′-[4-(2,2-Difluoro-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-175); (1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Enantiomer A) (Compound 1-176); (1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Enantiomer B) (Compound 1-177); (4′-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid (Compound 1-181); (4′-{4-[3-(3-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid (Compound 1-182); [1-(4′-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-183); [1-(4′-{4-[3-(3-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-184); [1-(4′-{4-[3-(3-Fluoro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-185); 1-(4′-{4-[1-Hydroxy-2-((S)-indan-1-ylamino)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-187); 2-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-3-phenyl-propionic acid (Compound 1-188); 1-{4′-[4-(1-Benzylamino-2-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-189); 1-{4′-[4-(2-Amino-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-190); 3-[4′-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid (Compound 1-191); 3-(4′-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Compound 1-192); 3-(4′-{4-[3-(3-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Compound 1-193); 1-{4′-[3-Methyl-4-(4-methyl-pyrazol-1-ylmethyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-194); 1-(4′-{3-Methyl-4-[(6-methyl-benzothiazol-2-ylamino)-methyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-195); 1-{4′-[4-(4-Bromo-pyrazol-1-ylmethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-196); 3-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid (Compound 1-197); 3-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-3-yl}-propionic acid (Compound 1-200); 3-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-propionic acid (Compound 1-201); 1-{4′-[3-Methyl-4-(2-phenylmethanesulfinyl-acetyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-202); 1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-cyclopropanecarboxylic acid (Compound 1-203); (1-{4′-[4-(1,5-Dimethyl-hex-4-enylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-204); 1-{4′-[4-(1,5-Dimethyl-hex-4-enylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-205); (1-{4′-[3-Methyl-4-(1-naphthalen-2-yl-ethylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-206); (1-{4′-[4-(1-Hydroxy-5-phenyl-pentyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-207); [1-(4′-{4-[5-(3,4-Dichloro-phenyl)-1-hydroxy-pentyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-208); [1-(4′-{4-[3-(4-Methoxy-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-211); 1-{4′-[3-Methyl-4-(5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-212); (1-{4′-[4-(1,3-Diphenyl-propylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-213); 1-{4′-[4-(1,3-Diphenyl-propylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-214); (cis)-2-{4′-[4-((R)-2-Benzyloxy-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-215); (cis)-2-{4′-[4-((S)-2-Benzyloxy-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Enantiomer A) (Compound 1-216); (cis)-2-{4′-[4-((S)-2-Benzyloxy-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Enantiomer B) (Compound 1-217); [1-(4′-{4-[3-(4-Chloro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-218); [1-(4′-{4-[3-(2-Chloro-6-fluoro-phenyl)-1-methyl-propylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-219); (1-{4′-[3-Methyl-4-(1-methyl-pent-4-enylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-226); 1-{4′-[3-Methyl-4-(1-methyl-pent-4-enylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-227); {4′-[3-Methyl-4-(1-methyl-pent-4-enylamino)-isoxazol-5-yl]-biphenyl-2-yl}-acetic acid (Compound 1-228); (1-{4′-[4-(4-Hydroxy-1-methyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-229); 1-{4′-[4-(4-Hydroxy-1-methyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-230); {4′-[4-(4-Hydroxy-1-methyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-acetic acid (Compound 1-231); {4′-[4-(3-Benzo[1,3]dioxol-5-yl-1-methylpropylamino)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-acetic acid (Compound 1-232); (1-{4′-[4-(3-Benzo[1,3]dioxol-5-yl-1-methyl-propylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-233); 3-(4′-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Enantiomer A) (Compound 1-234); 3-(4′-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Enantiomer B) (Compound 1-235); [1-(4′-{4-[2-(4-Methoxy-phenyl)-1-methyl-ethylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-236); 1-(4′-{4-[2-(4-Methoxy-phenyl)-1-methyl-ethylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-237); (4′-{4-[2-(4-Methoxy-phenyl)-1-methyl-ethylamino]-3-methyl-isoxazol-5-yl}-biphenyl-2-yl)-acetic acid (Compound 1-238); (4′-{4-[1-Hydroxy-2-(3-trifluoromethyl-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid (Compound 1-241); 3-(4′-{4-[1-Hydroxy-2-(3-trifluoromethyl-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Compound 1-242); [1-(4′-{4-[1-Hydroxy-2-(3-trifluoromethyl-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-244); 4-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-4-oxo-butyric acid (Compound 1-245); (1-{4′-[4-(1-Hydroxy-3-methyl-3-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-246); [1-(4′-{4-[1-Hydroxy-3-(4-methoxy-phenyl)-propyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid (Compound 1-247); 1-{4′-[4-(Hydroxy-phenethylcarbamoyl-methyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-249); 1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl-methyl}-cyclopropanecarboxylic acid (Compound 1-250); 1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-3-yl-methyl}-cyclopropanecarboxylic acid (Compound 1-251); 1-{4′-[4-(Benzylcarbamoyl-hydroxy-methyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-252); 1-(4′-{4-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-253); (1-{4′-[4-(1-Acetylamino-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-256); 1-{4′-[4-(1-Methanesulfonylamino-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-257); 1-(4′-{4-[(Benzyl-methyl-carbamoyl)-hydroxy-methyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-258); 1-{4′-[3-Methyl-4-((E)-2-phenylmethanesulfonyl-vinyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-259); 1-{4′-[4-(1-Hydroxy-4-pyridin-3-yl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-260); 1-{4′-[4-(1-Hydroxy-4-pyridin-4-yl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-261); 1-(4′-{3-Methyl-4-[(E)-2-(phenylmethanesulfinyl)-vinyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Enantiomer A) (Compound 1-262); 1-(4′-{3-Methyl-4-[(E)-2-(phenylmethanesulfinyl)-vinyl]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Enantiomer B) (Compound 1-263); (4′-{4-[1-Hydroxy-2-(3-trifluoromethyl-benzylsulfanyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid (Compound 1-266); 1-{4′-[3-Methyl-4-(1,2,3,4-tetrahydro-naphthalen-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-270); 1-{4′-[4-(Indan-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-271); {4′-[4-((S)-2-Benzylsulfanyl-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid (Compound 1-272); 3-{4′-[4-((S)-2-Benzylsulfanyl-1-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid (Compound 1-273); 3-(4′-{4-[(S)-1-Hydroxy-2-(3-trifluoromethyl-benzylsulfanyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid (Compound 1-274); 1-(4′-{4-[1-Hydroxy-2-(2,2,2-trifluoro-ethylsulfanyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-276); 1-{4′-[4-(1-Hydroxy-2-phenylsulfanyl-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-277); 1-{4′-[3-Methyl-4-(1-methyl-2-phenylsulfanyl-ethylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-278); 1-{4′-[3-Methyl-4-(1-methyl-2-phenoxy-ethylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-279); 1-{4′-[3-Methyl-4-(quinolin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-280); 1-{4′-[4-(1-Benzo[b]thiophen-2-yl-ethylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-284); (1-{4′-[4-(1-Benzo[b]thiophen-2-yl-ethylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-286); (1-{4′-[4-(1,3-Dimethyl-3-phenyl-butylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid (Compound 1-287); 1-{4′-[3-Methyl-4-((E)-1-methyl-3-phenyl-allylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-288); 1-{4′-[3-Methyl-4-(pyridin-3-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-290); 1-{4′-[4-(5-Methoxy-pyridin-3-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-291); 1-{4′-[4-(3-Bromo-benzoylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-292); 1-{4′-[3-Methyl-4-(6-propoxy-pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-293); 1-{4′-[4-(6-Ethoxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-294); 1-{4′-[4-(6-Butoxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-295); 1-{4′-[3-Methyl-4-(pyridin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-296); 1-{4′-[4-(6-Isopropoxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-297); 6-{5-[4′-(1-Carboxy-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-ylamino}-pyridine-2-carboxylic acid (Compound 1-298); 1-(4′-{4-[6-(2-Dimethylamino-ethylcarbamoyl)-pyridin-2-ylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-299); 1-(4′-{4-[6-(2,2-Dimethyl-propylcarbamoyl)-pyridin-2-ylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-300); 1-{4′-[4-(6-tert-Butoxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-301); 1-{4′-[4-(6-Hydroxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-302); 1-{4′-[4-(6-Dodecyloxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-303); 1-{4′-[4-(6-Methoxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-304); 4′-[4-(Benzyloxycarbonylamino-methyl)-3-methyl-isoxazol-5-yl]-biphenyl-3-carboxylic acid (Compound 1-305); {1-[4′-(5-Methyl-4-phenethylsulfanylmethyl-isoxazol-3-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid (Compound 1-306); (4′-{3-Methyl-4-[(S)-1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propynoic acid (Compound 1-307); 1-(4′-{4-[3-(3-Bromo-phenyl)-ureido]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid (Compound 1-308); 1-{4′-[4-(6-Isopropoxy-1-oxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-309); 1-{4′-[4-(5-Isopropoxy-pyridin-3-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-310); 1-{4′-[4-(6-Acetyl-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-311); 1-{4′-[4-(6-Carbamoyl-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-312); 1-{4′-[4-(6-Bromo-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1-313); N-Sulfonylmethyl carbamic acid (S)-2-benzyloxy-1-{5-[4′-(1-methanesulfonylaminocarbonyl-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-yl}-ethyl ester (Compound 2-4); 4-Methyl-N-(1-{4′-[3-methyl-4-(3-p-toluenesulfonyl-ureido)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarbonyl)-benzenesulfonamide (Compound 2-5); Cyclopropanesulfonic acid (1-{4′-[4-(3-cyclopropylsulfonyl-ureido)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarbonyl)-amide (Compound 2-6); N-(1-{4′-[4-(1-Hydroxy-2-m-tolylsulfanyl-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarbonyl)-methanesulfonamide (Compound 2-13); N-[1-(4′-{4-[1-Hydroxy-2-(3-methoxy-phenylsulfanyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarbonyl]-methanesulfonamide (Compound 2-14); N-Sulfonylmethyl carbamic acid 1-(5-{4′-[1-(2-methanesulfonylamino-2-oxo-ethyl)-cyclopropyl]-biphenyl-4-yl}-3-methyl-isoxazol-4-yl)-4-phenyl-butyl ester (Compound 2-15); and N-[2-(1-{4′-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropyl)-acetyl]-methanesulfonamide (Compound 2-16); or a pharmaceutically acceptable salt thereof.