Patent ID: 6322771
Filing Date: 2001-11-27
Classification: A61K,A61P,C07H

Abstract:
A method to diagnose coronary artery stenosis in a mammal comprising:(a) parenterally administering to said mammal an amount of a compound of formula (I): ##STR6##wherein (a) each R is individually hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl or phenyl(C.sub.1 -C.sub.3)-alkyl;(b) X is --CH.sub.2 OH, --CO.sub.2 R.sup.2, --OC(O)R.sup.2, --CH.sub.2 OC(O)R.sup.2 or C(O)NR.sup.3 R.sup.4 ;(c) each of R.sup.2, R.sup.3 and R.sup.4 is individually H, C.sub.1-6 -alkyl; C.sub.1-6 -alkyl substituted with 1-3 C.sub.1-6 -alkoxy, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1-6 -alkylthio, halogen hydroxy, amino, mono(C.sub.1-6 -alkyl)amino, di(C.sub.1-6 -alkyl)amino, or C.sub.6-10 -aryl, wherein aryl may be substituted with 1-3 halogen, C.sub.1-6 -alkyl, hydroxy, amino, mono(C.sub.1-6 -alkyl)amino, or di(C.sub.1-6 -alkyl)amino; C.sub.6-10 -aryl; or C.sub.6-10 -aryl substituted with 1-3 halogen, hydroxy, amino, mono(C.sub.1-6 -alkyl)amino, di(C.sub.1-6 -alkyl)amino or C.sub.1-6 -alkyl;(d) each of R.sup.3 and R.sup.4 is individually hydrogen, C.sub.3-7 -cycloalkyl, or any of the meanings of R.sup.2 ; and(e) R.sup.1 is (X--(Z)--).sub.n [(C.sub.3 -C.sub.10)cycloalkyl]--(Z')-- wherein Z and Z' are individually (C.sub.1 -C.sub.6)alkyl, optionally interrupted by 1-3 S or nonperoxide O, or is absent, and n is 1-3; or a pharmaceutically acceptable salt thereof; wherein said amount is effective to provide coronary artery vasodilation; and(b) performing a technique on said mammal selected from the soup consisting of myocardial perfusion imaging, ventricular function imaging and a method for measuring coronary blood flow velocity, to detect the presence and/or assess the severity of said coronary artery stenosis.