Patent ID: 9067998
Filing Date: 2015-06-30
Classification: C07K,C12Q

Abstract:
1. A method of treating a solid tumor; melanoma; renal cell carcinoma; non small-cell lung cancer; bladder cancer; Hodgkin's lymphoma; or gastric cancer in a human by targeting PD-1 in the human, the method comprising administering an antibody or antibody fragment to the human, wherein the antibody or antibody fragment specifically binds a PD-1 encoded by a PD-1 nucleotide sequence comprising a SNP selected from the group consisting of: rs7568402; rs28699177; rs28542728; rs118117097; rs28570544; rs118027315; rs191919871; rs6707556; rs142909968; rs36084323; rs10204225; rs11568821; rs2227981; and rs2227982; wherein the antibody or antibody fragment comprises a human gamma-4 heavy chain constant region that comprises an amino acid selected from the group consisting of: a Leu at position 189 shown in SEQ ID NO: 73 and an Arg at position 289 shown in SEQ ID NO: 73; and wherein said human comprises (i) an IGHG4*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-4 heavy chain constant regions comprising said selected amino acid; and (ii) a PD-1 nucleotide sequence comprising said selected SNP.