Patent ID: 6214861
Filing Date: 2001-04-10
Classification: A61K,A61P,C07K

Abstract:
A compound represented by the formula: ##STR702##or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein n represents 0 or 1;R.sup.1 represents alkyl of 1-5 carbon atoms, alkenyl of 2-5 carbon atoms, alkynyl of 2-5 carbon atoms, hydroxyalkyl of 1-3 carbon atoms, alkoxyalkyl of 1-3 alkyl and 1-3 alkoxy carbon atoms, a cyanoalkyl of 1-3 alkyl carbon atoms, imidazolylmethyl, --CH.sub.2 CONH.sub.2, --CH.sub.2 CH.sub.2 CONH.sub.2, --CH.sub.2 S(O).sub.2 NH.sub.2, --CH.sub.2 SCH.sub.3, --CH.sub.2 S(O)CH.sub.3, --CH.sub.2 S(O).sub.2 CH.sub.3, --C(CH.sub.3).sub.2 SCH.sub.3, --C(CH.sub.3).sub.2 S(O)CH.sub.3 or --C(CH.sub.3).sub.2 S(O).sub.2 CH.sub.3 radicals;R.sup.2 represents radicals of alkyl of 1-5 carbon atoms, aralkyl of 1-3 alkyl carbon atoms, alkylthioalkyl of 1-3 alkyl carbon atoms, arylthioalkyl of 1-3 alkyl carbon atoms or cycloalkylalkyl of 1-3 alkyl carbon atoms and 3-6 ring member carbon atoms;R.sup.3 represents radicals of alkyl radical of 1-5 carbon atoms, cycloalkyl of 5-8 ring members or cycloalkylmethyl radical of 3-6 ring members;R.sup.4 represents phenyl, 2-naphthyl, 4-methoxyphenyl, 4-hydroxyphenyl, 3,4-dimethoxy phenyl, 3-aminophenyl, 4-aminophenyl, benzothiazol-5-yl, benzothiazol-6-yl, 2-amino-benzothiazol-5-yl, 2-(methoxycarbonylamino)benzothiazol-5-yl, 2-amino-benzothiazol-6-yl, 2-(methoxycarbonylamino)benzothiazol-6-yl, 5-benzoxazolyl, 6-benzoxazolyl, 6-benzopyranyl, 3,4-dihydrobenzopyran-6-yl, 7-benzopyranyl, 3,4-dihydrobenzopyran-7-yl, 2,3-dihydrobenzofuran-5-yl, benzofuran-5-yl, 1,3-benzodioxol-5-yl, 2-methyl-1,3-benzodioxol-5-yl, 2,2-dimethyl-1,3-benzodioxol-5-yl, 2,2-dideutero-1,3-benzodioxol-5-yl, 2,2-difluoro-1,3-benzodioxol-5-yl, 1,4-benzodioxan-6-yl, 5-benzimidazolyl, 2-(methoxycarbonylamino)benzimidazol-5-yl, 6-quinolinyl, 7-quinolinyl, 6-isoquinolinyl or 7-isoquinolinyl radicals;R.sup.10 represents hydrogen, alkyl of 1-3 carbon atoms, benzyl, phenylmethoxycarbonyl, tert-butoxycarbonyl or 4-methoxyphenylmethoxycarbonyl radicals;R.sup.11 represents hydrogen, hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl is 1-3 carbon atoms; andR.sup.12 and R.sup.13 each independently represent hydrogen, hydroxy, alkoxy, 2-hydroxyalkoxy, hydroxyalkyl or alkoxyalkyl radicals, wherein alkyl is 1-3 carbon atoms; or R.sup.11 and R.sup.12 or R.sup.12 and R.sup.13 along with the carbon atoms to which they are attached represent a benzo radical, which is optionally substituted with at least one hydroxy or alkoxy radical of 1-3 carbon atoms.