Patent ID: 9023395
Filing Date: 2015-05-05
Classification: A61K,A61P,B82Y

Abstract:
1. An activated polymeric nanoparticle for targeted drug delivery comprising: an active agent disposed within a biodegradable nanoshell having a targeting agent, wherein the nanoshell comprises a poly-lactic-co-glycolic acid biocompatible polymer in contact with an amphiphilic polyol stabilizing agent; a spacer compound non-covalently sequestered in the nanoshell wall, wherein the spacer is selected from the group consisting of bis(sulfosuccinimidyl)suberate, ethylene glycolbis-(sulfosuccinimidylsuccinate), disuccinimidyl glutarate, N-[e-maleimidocaproyloxy]sulfosuccinimide ester, N-[b-maleimidopropyloxy] succinimide ester, and 1,8-bismaleimidodiethyleneglycol; and the targeting agent is bound to the non-covalently sequestered spacer compound such that the targeting agent is displayed on the exterior surface of the nanoshell.