Patent ID: 6248892
Filing Date: 2001-06-19
Classification: B01J,C07D

Abstract:
A process for preparing arylpyridines of the formula (I) ##STR7##whereR.sub.1a to R.sub.9a are identical or different and are hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.12 -alkenyl, C.sub.2 -C.sub.12 -alkynyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.12 -acyloxy, aryl, F, Cl, CN, CX.sub.3, where X=F, Cl or Br, and CHCHCOO-(C.sub.1 -C.sub.12 -alkyl), which comprises reacting a halopyridine of the formula (II) ##STR8##with an aryl Grignard compound of the formula (III) ##STR9##where Hal is chlorine or bromine, in the presence of a palladium catalyst of the formula (IV) ##STR10##whereR.sub.1 to R.sub.8 are identical or different and are hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.4 -alkoxy, fluorine, NH.sub.2, NH-(C.sub.1 -C.sub.4 -alkyl), N(C.sub.1 -C.sub.4 -alkyl).sub.2, CO.sub.2 -alkyl-(C.sub.1 -C.sub.4) or phenyl, or R.sub.1 and R.sub.2, or R.sub.2 and R.sub.3, or R.sub.3 and R.sub.4 ; R.sub.5 and R.sub.6, or R.sub.6 and R.sub.7, or R.sub.7 and R.sub.8 together form an aliphatic or aromatic ring, R.sub.9 to R.sub.12 are identical or different and are C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.12 -cycloalkyl or aryl, which are optionally substituted by from 1 to 3 substituents selected from the group consisting of C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy and halogen, and Y is an anion selected from the group of an organic acid, an inorganic acid and pyrazolyl.