Patent ID: 6075043
Filing Date: 2000-06-13
Classification: A01N,A61P,C07D

Abstract:
A compound of formula (I): ##STR9## or a pharmaceutically, veterinarily or agriculturally acceptable salt thereof, or a pharmaceutically, veterinarily or agriculturally acceptable solvate of either entity,whereinR.sup.1 is 2,4,6-trisubstituted phenyl wherein the 2- and 6-substituents are each independently selected from halo and the 4-substituent is selected from C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo, C.sub.1 to C.sub.4 alkoxy optionally substituted with one or more halo, S(O).sub.n C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo, halo and pentafluorothio; or 3,5-disubstituted pyridin-2-yl wherein the 3-substituent is halo and the 5-substituent is selected from C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo, C.sub.1 to C.sub.4 alkoxy optionally substituted with one or more halo, S(O).sub.n C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo, halo and pentafluorothio;R.sup.3 is C.sub.1 to C.sub.4 alkyl optionally substituted with hydroxy or with one or more halo; cyano, C.sub.1 to C.sub.5 alkanoyl or phenyl;R.sup.5 is hydrogen, C.sub.1 to C.sub.4 alkyl, amino or halo;R.sup.2 and R.sup.4 are each independently selected from hydrogen, C.sub.1 to C.sub.4 alkyl, fluoro, chloro and bromo or, together with the carbon atom to which they are attached, form a C.sub.3 to C.sub.6 cycloalkyl group;R.sup.6 and R.sup.8 are each independently selected from hydrogen, C.sub.1 to C.sub.4 alkyl, fluoro, chloro and bromo;or, when R.sup.2 and R.sup.4 do not form part of a cycloalkyl group, R.sup.2 and R.sup.6, together with the carbon atoms to which they are attached, may form a C.sub.5 to C.sub.7 cycloalkyl group;R.sup.7 is hydrogen, C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo, or C.sub.1 to C.sub.4 alkoxy; andn is 0, 1 or 2.