Patent ID: 8586325
Filing Date: 2013-11-19
Classification: C07D,C07K,C12N,C12Q,G01N

Abstract:
1. A compound comprising a fluorogenic dye moiety of the formula: wherein: n is 0, 1, 2 or 3; n′ is 1, 2, 3, 4, or 5; m′ is 0 or 1; m″ is 1, when m′ is 0; m″ is 0, 2, 3 or 4, when m′ is 1; W is NH, O, or S; X is O or S; ψ comprises a biologically compatible counter ion; d is a number of ψ sufficient to render overall charge of the substrate neutral; R B is an enzyme substrate moiety capable of being cleaved by a caspase enzyme.