Patent ID: 6207643
Filing Date: 2001-03-27
Classification: C07K

Abstract:
A compound of the formula:R'-X.sub.1 -X.sub.a -X.sub.b -X.sub.2 -NH.sub.2wherein:(a) R' is selected from the group consisting of Phe, Tyr, a hydrocinnamyl group, a p-hydroxyhydrocinnamic acyl group, and a polypeptide group, which said polypeptide group comprises all or a portion of an allatostatin neuropeptide which is naturally contiguous to the C terminal tetrapeptide X,-Phe-Gly-X.sub.2 -NH.sub.2 ;(b) X.sub.1 is selected from the group consisting of Asn, Asp, Gly, Ser, and Ala;(c) X.sub.2 is selected from the group consisting of Leu and Ile;(d) X.sub.a, X.sub.b is selected from the group consisting of:(i) -Phe-Caa- wherein Caa is a cycloalkyl alanine group selected from the group consisting of cylcopropyl alanine having the structure: ##STR2##or cyclobutyl alanine having the structure: ##STR3##(ii) -Aic-Gly- wherein Aic is a 2-amino-indane-2-carboxyl group having the structure: ##STR4##(iii) -Bzd- wherein Bzd is a 1,4-benzodiazepine group having the structure: ##STR5##and(iv) -Aic-Caa-.