Patent ID: 6143790
Filing Date: 2000-11-07
Classification: A61K,C07C,C07D,Y10S

Abstract:
A compound or a pharmaceutically acceptable salt, prodrug or ester thereof having the formula: ##STR97## Y is hydrogen, lower alkyl radical, lower alkenyl radical, lower alkynyl radical, aromatic hydrocarbon radical, or alicyclic hydrocarbon radical, wherein all said radicals may optionally be substituted with hydrogen, lower alkyl, nitro, amino, alicyclic hydrocarbon radicals, or aromatic hydrocarbon radicals which may be optionally substituted with lower alkyl;X is lower alkylene radical, lower alkenylene radical, lower alkynylene radical, aromatic hydrocarbon radical, (CH.sub.2).sub.m Q(CH.sub.2).sub.n, where m=1-3, n =1-3, and Q is sulfur, sulfinyl, sulfonyl, oxygen, carbonyl, lower alkynyl radical, aromatic hydrocarbon radical, or alicyclic hydrocarbon radical wherein all said radicals are optionally substituted with hydrogen, halogen and lower alkyl;R.sup.1, R R.sup.3 and R.sup.4 are independently selected from the group consisting of hydrogen and lower alkyl;A is lower alkyl radical, lower alkenyl radical,lower alkynyl radical, alicyclic hydrocarbon radical, carbonyl, or aromatic hydrocarbon radical, wherein all said radicals are optionally substituted with hydrogen, lower alkyl, hydroxyl, lower alkoxy, alkoxycarbonyl, alkylaryloxy, thiol, lower thioalkoxy, thioalkylaryloxy, thioaryloxy, sulfinylalkyl, sulfinylalkylaryl, sulfinylaryl, sulfonylalkyl, sulfonylalkylaryl, sulfonylaryl, halogen, aromatic hydrocarbon radicals, or alicyclic hydrocarbon radicals;B is hydrogen, lower alkyl radical, lower alkenyl radical, lower alkynyl radical, lower alkoxy radical, hydroxy, alkylaryloxy, thiol, lower thioalkoxy, lower thioalkylaryloxy, thioaryloxy, sulfinylalkyl, sulfinylalkylaryl, sulfinylaryl, sulfonylalkyl, sulfonylalkylaryl, sulfonylaryl, aromatic hydrocarbon radical, alicyclic hydrocarbon radical, or NHOH, wherein all said radicals are optionally substituted with hydrogen, lower alkyl, hydroxyl, lower alkoxy, halogen, aromatic hydrocarbon radicals,or alicyclic hydrocarbon radical;with the proviso that when A is CHOR, B cannot be OR and Y cannot be amino wherein R is alkyl;with the proviso that when A is carbonyl, B is not hydroxy, aryloxy, thioalkoxy, alkoxy, or NHOH.