Patent ID: 6720334
Filing Date: 2004-04-13
Classification: C07D

Abstract:
A compound of the formula (I): whereinX is ethylene, propylene, or butylene; Y is â€”COâ€” or â€”CSâ€”; Z is a â€”NR6â€”, â€”NR6â€”COâ€”, â€”NR6â€”SO2â€”, or â€”NR7â€”; R1 is aryl, heteroaryl, C1-10 alkyl, or C2-10 alkenyl, each of which may be unsubstituted or substituted by one or more substituents independently selected from the group consisting of: -alkyl; -aryl; -substituted aryl; -heterocyclyl; â€”O-alkyl; â€”COâ€”O-alkyl; â€”S(O)0-2-alkyl; -(alkyl)0-1â€”N(R6)2; â€”P(O)(O-alkyl)2; -halogen; -haloalkyl; -haloalkoxy; and â€”CN; R2 is selected from the group consisting of: -hydrogen; â€”C1-10 alkyl; and â€”C1-10 alkyl-Oâ€”C1-10alkyl; R3 and R4 are independently selected from the group consisting of hydrogen, and methyl; R5 is H or C1-10 alkyl, or when R5 is C1-10 alkyl and X is ethylene, propylene or butylene, R5 can join with X to form a ring that contains one nitrogen atom; each R6 is independently H or C1-10 alkyl; R7 is H or C1-10 alkyl which may be interrupted by one hetero atom, or when R1 is alkyl and R7 is C1-10 alkyl which may be interrupted by one hetero atom, R7 and R1 can join to form a ring containing one nitrogen atom and optionally one additional hetero atom; or a pharmaceutically acceptable salt thereof.