Patent ID: 9204895
Filing Date: 2015-12-08
Classification: A61B,A61D,A61K,A61M

Abstract:
1. A method of fixed time artificial insemination comprising: deploying a drug delivery device into a vaginal lumen of an animal subject, wherein the device comprises a housing containing (i) a first reservoir containing a first drug formulation comprising a gonadotropin-releasing hormone, (ii) a second reservoir containing a second drug formulation comprising a prostaglandin, (iii) a third reservoir containing a third drug formulation comprising a gonadotropin-releasing hormone, (iv) a porous membrane sidewall adjacent the vaginal lumen, and (v) one or more actuation systems configured to drive the first, second, and third drug formulations from the first, second, and third reservoirs; thereafter driving the first drug formulation out of the first reservoir at a first time; driving the second drug formulation out of the second reservoir at a second time, which is after the first time; driving the third drug formulation out of the third reservoir at a third time, which is after the second time; and artificially inseminating the animal subject at a fourth time, which is after the third time, wherein the porous membrane sidewall comprises a fluidic valve configured such that a critical threshold pressure from about 0.1 psi to about 100 psi is required to drive the first, second, and third drug formulations from the first, second, and third reservoirs to the vaginal lumen.