Patent ID: 6498182
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A compound of formula I, formula Ia, or formula Ib whereinR1 is (i) hydrogen; (ii) linear or branched C1-C6 alkoxy; (ii) â€”Oâ€”(C1-C6 alkyl)â€”Q, where the alkyl group is linear or branched, and Q is phenyl, naphthyl, or a heterocycle having 5 to 10 ring atoms, where at least one of the ring atoms is O, N, or S; where n is an integer 1 or 2, and each of Q1 and Q2 is independently hydrogen or C1-C6 alkyl, where the alkyl group is linear or branched; or where n is an integer 1 or 2;R2 is (i) hydroxy; (ii) linear or branched C1-C6 alkoxy; (iii) â€”Oâ€”COâ€”(C1-C6 alkyl), where the alkyl group is linear or branched; or (iv) â€”Oâ€”CO-phenyl or â€”Oâ€”CO-naphthyl; each of R3 and R4 is independently (i) linear or branched C1I-C6 alkyl; or (ii) cyclopentane or cyclohexane; Ra is â€”CH2â€”COâ€”(C1-C6 alkyl), where the alkyl group is linear or branched; and Rb is (i) â€”COâ€”(C1-C6 alkyl), where the alkyl group is linear or branched; or (ii) hydrogen; provided that the compound 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione is excluded;or a pharmaceutically and pharmacologically acceptable salt or hydrate thereof.