Patent ID: 7504433
Filing Date: 2009-03-17
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein: (a) R1 is selected from the group consisting of hydrogen, C (b) R1′ are each independently selected from the group consisting of hydroxy, cyano, nitro, halo, oxo, C (c) R2, R26, R27, R28, and R31 are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (d) X is O; (e) U is an aliphatic linker; (f) Y is selected from the group consisting of C, O, S, NH and a single bond; (g) E is C(R3)(R4)A wherein (h) R8 is selected from the group consisting of hydrogen, C (i) R9 is selected from the group consisting of hydrogen, C (j) R10 is selected from the group consisting of C (k) R11 is selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (l) R12′, R12″, R13′, R14′, R15′, R16′, R17′, R18′, R19′, R20′, R21′, R22′, R23′, R24′, and R25′ are each independently selected from the group consisting of hydrogen, C