Patent ID: 6846918
Filing Date: 2005-01-25
Classification: C07H

Abstract:
1. An oligonucleotide comprising a purine nucleoside modified at the 2-, 6- or 8-position of the purine ring prepared according to a method comprising comprising the steps of: reacting a purine starting material containing a leaving group attached to the 2-, 6- or 8-position of said purine starting material with a functionalized alkene having the formula: wherein Y is selected from the group consisting of —CHROH, —C(O)R, —COOR, —C(O)NRR′, —CN, a substituted or unsubstituted aryl group or heterocylic group, selected from the group consisting of phenyl, 2-,3- or 4-hydroxyphenyl, 2-,3- or 4-pyridyl and 1H-tetrazol-5-yl; R and R′ are independently selected from the group consisting of H, substituted or unsubstituted alkyl, alkenyl and aryl; and n is an integer from 0-15 in the presence of a palladium catalyst of the general formula PdL isolating said modified nucleoside or nucleotide.