Patent ID: 9074211
Filing Date: 2015-07-07
Classification: A61P,C12N,C12Y

Abstract:
1. A blunt-ended double-stranded RNA (dsRNA) for inhibiting expression of a MAP4K4 gene, comprising: (1) a sense strand of 25, 26, 27, 28, 29 or 30 nucleotides in length, having a 5′-end and a 3′-end, wherein the sense strand is highly modified with 2′-modified ribose sugars, comprising a continuous stretch of 2′-modified ribose sugars on the 5′-end, a continuous stretch of 2′-modified ribose sugars on the 3′-end and a central region that is unmodified, and, (2) an antisense strand of 25, 26, 27, 28, 29 or 30 nucleotides in length, having a 5′-end and a 3′-end, which hybridizes to the sense strand, wherein the sense strand comprises a sequence selected from the group consisting of: SEQ ID NO: 1, 3, 5, 7, 11, 12, 13, 15, 17, 19, 21, 25, 27, 31, 33, 35, 37, 45 and 50, and wherein the dsRNA does not form a hairpin.