Patent ID: 6225311
Filing Date: 2001-05-01
Classification: A61K,C07C,C07D,C07F

Abstract:
Compounds having the formula: ##STR68##wherein:X is SO.sub.2 or --P(O)--R.sub.10 ;Y is aryl or heteroaryl, with the proviso that X and Z may not be bonded to adjacent atoms of Y;Z is O, NH, CH, or S;R.sub.2 is hydrogen, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl of 3-6 carbon atoms, piperidinyl, piperazinyl, morpholinyl. tetrahydropyranyl, tetrahydrofuranyl, pyrrolidinyl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms;R.sub.1 and R.sub.3, together with the atoms to which they are attached, may form a 6 membered ring wherein R.sub.1 and R.sub.3 represent divalent moieties of the formula: ##STR69##wherein Q is a carbon-carbon single or double bond, O, S, SO, SO.sub.2, --N--R.sub.11, or --CONR.sub.14 :m=2-3s is 0-2; provided that Q, s, and m, taken together represent 4 atoms;R.sub.4 and R.sub.5 are each, independently, hydrogen or alkyl of 1-6 carbon atoms, --CN, or --CCH;R.sub.6 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, piperidinyl piperazinyl, morpholinyl, tetrahydropyranyl, tetrahydrofuranyl, pyrolidinyl;R.sub.8 and R.sub.9 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, aralkyl, heteroaryl, heteroaralkyl, piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, tetrahydrofuranyl, pyrrolidinyl;R.sub.10 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl or heteroaryl;R.sub.11 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl, --S(O).sub.n R.sub.8, --COOR.sub.8, --CONRR.sub.8 R.sub.9, --SO.sub.2 NR.sub.8 R.sub.9 or --COR.sub.8 ;R.sub.12 and R.sub.13 are independently selected from H, --OR.sub.8, --NR.sub.8 R.sub.9, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl, --COOR.sub.8 ; --CONR.sub.8 R.sub.9 ; or R.sub.12 and R.sub.13 together form a --C.sub.3 -C.sub.6 -cycloalkyl of 3-6 carbon atoms or a --C.sub.5 -C.sub.8 -cycloheteroalkyl ring; or R.sub.12 and R.sub.13,together with the carbon to which they are attached, form a carbonyl group;R.sub.14 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms or cycloalkyl of 3-6 carbon atoms;and n is 0-2;or a pharmaceutically acceptable salt thereof.