Patent ID: 6114537
Filing Date: 2000-09-05
Classification: A61P,C07C,C07D

Abstract:
3,5-Disubstituted 1,2,4-thiadiazole compounds corresponding to the general formula: ##STR54## wherein Q represents a group --T--(--AMA--] L where T is a chemical spacer group bonded to the thiadiazole nucleus and selected from ##STR55## L is an N-terminal peptide protector group or a terminal group ##STR56## where R' and R"" are as defined below in group Y' and --AMA-- is an amino acid or peptide residue --[NH--CHA.sup.1 --CO].sub.n -- where A.sup.1 is any one of the known amino acid .alpha.-substituents and n is an integer from 1 to 3;and Y' is lower alkyl, lower alkoxy, amino, carboxyl, or lower alkoxycarbonyl [or 1-piperazinyll; lower alkyl substituted with 1 or 2 substituents selected from hydroxy, lower alkylcarbamoyl, phenyl, halophenyl, heterocyclyl, carboxy and lower alkoxycarbonyl; benzyl; phenyl optionally substituted with amino, halo, hydroxy, lower alkoxy, lower alkyl, lower alkylamino, or di(lower alkyl)amino; heterocyclyl optionally substituted with 1-3 substituents selected from nitro, amino, halo, hydroxy, lower alkoxy, lower alkyl, lower alkylamino, or di(lower alkyl)amino; 1,1-diphenylmethyl wherein both phenyl rings are optionally substituted with halo, amino, hydroxy or lower alkoxy; 2-pyridyl where the pyridyl ring is optionally substituted with 1-3 substituents selected from nitro, amino, halo, hydroxy, lower alkoxy, lower alkyl, lower alkylamino, or di(lower alkyl)amino; or a group --CR.sub.2 --CO--NH-loweralkyl.