Patent ID: 6268339
Filing Date: 2001-07-31
Classification: C07K

Abstract:
A lanthionine-bridged peptide of the formula: ##STR43##whereinR.sub.1 represents Gly-Phe;R.sub.2 represents an amino acid selected from the group consisting of D-Phe, D-.beta.-Nal, Tyr, TrpNH.sub.2, ThrNH.sub.2 and Thr(ol); or represents H, acyl or aracyl with 2 to 12 carbon atoms; or represents an amino acid sequence selected from the group consisting of Pro-Arg-Gly and Pro-Leu-Gly;R.sub.3 represents an amino acid selected from the group consisting of D-Phe, D-.beta.-Nal, Tyr, TrpNH.sub.2, ThrNH.sub.2 and Thr(ol); or represents OH or NH.sub.2 ; or represents an amino acid sequence selected from the group consisting of Pro-Arg-Gly and Pro-Leu-Gly; or ##STR44##can be replaced by CH.sub.2 OH; andR.sub.4, R.sub.5, R.sub.7 and R.sub.8 independently represent hydrogen or a methyl group.