Patent ID: 6825211
Filing Date: 2004-11-30
Classification: C07C,C07F

Abstract:
A compound of formula I: whereinR1, R2, R3, R4, R7, R8, R9, and R10 are each independently hydrogen, carboxy, tetrazolyl, â€”SO2OH, â€”PO(OH)2, â€”B(OH)2, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, cyano, halo, â€”CONRaRb, â€”NRcRd, â€”SRe, aryl, heteroaryl, aryl(C1-C6)alkyl, diaryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl, wherein any aryl or heteroaryl may optionally be substituted with 1, 2 or 3 substituents selected from the group consisting of halo, hydroxy, (C1-C6)alkoxy, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, and carboxy; R5 is carboxy, tetrazolyl, (C1-C6)alkoxycarbonyl, â€”SO2OH, â€”B(OH)2, or â€”PO(OH)2; R6 is hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, (C1-C6)alkoxycarbonyl, or (C1-C6)alkanoyl; X is â€”N(Rx)â€”, wherein Rx is hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, aryl, aryl(C1-C6)alkyl, (C1-C6)alkoxycarbonyl, or aryl(C1-C6)alkoxycarbonyl; each Ra Rb and Re is independently hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, aryl, heteroaryl, benzyl, or phenethyl; and each Rc or Rd is independently hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkanoyl, aryl, heteroaryl, benzyl, or phenethyl; or Rc and Rd together with the nitrogen to which they are attached are triazolyl, imidazolyl, oxazolidinyl, isoxazolidinyl, pyrrolyl, morpholino, piperidino, pyrrolidino, pyrazolyl, indolyl, or tetrazolyl; or a pharmaceutically acceptable salt thereof; wherein at least one of R1, R2, R3, R4, R9, and R10 is carboxy, tetrazolyl, â€”SO2OH, â€”PO(OH)2, or â€”B(OH)2.