Patent ID: 6756374
Filing Date: 2004-06-29
Classification: A61P,C07B,C07C,C07D

Abstract:
A compound of formula: or the pharmaceutically acceptable salts or esters thereof, whereinR1 is selected from the group consisting of H, lower alkyl that optionally may be substituted with a group selected from OR6, cycloalkyl, and NR7R8, cycloalkyl, COR9, and SO2R10; R2 is selected from the group consisting of H, F, Cl, and CH3; R3, R4 and R5 are each independently selected from the group consisting of H, lower alkyl, which optionally may be substituted with a group selected from OR6 and NR7R8, OR11, NR12R13, halogen, NO2, CONR6R9, NHSO2R14, CN S-lower alkyl, OCF3, and OCHF2, provided that R3 and R4 or R4 and R5 are not simultaneously â€”OCH3, and provided further that R4 is not â€”Cl when R3 or R5 is â€”NO2; R6 and R9 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OH and halogen; R7 and R8 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OR6, or, alternatively, R7 is H and R8 is OH, or, alternatively, NR7R8 can optionally form a ring having 5-6 ring atoms, said ring atoms comprising, in addition to the nitrogen atom to which R7 and R8 are bonded, carbon ring atoms, said carbon ring atoms optionally being replaced by one or more additional hetero atoms and said ring atoms being optionally substituted by the group consisting of one or more of OR6 and lower alkyl which itself may be optionally substituted by OH; R10 selected from the group consisting of lower alkyl which optionally may be substituted by one or more chlorine or fluorine, and NH2; R11 is selected from the group consisting of H, and lower alkyl that optionally may be substituted by OR6, COOH, halogen and NR15R16; R12 and R13 are independently selected from the group consisting of H, lower alkyl that optionally may be substituted with a group selected from OR6, COOH and NR15R16, COR17, and SO2R18, provided that only one of R12 and R13 is COR17or SO2R18, or alternatively NR12R13 can optionally form a ring having 5-6 ring atoms, said ring atoms comprising, in addition to the nitrogen atom to which R12 and R13 are bonded, carbon ring atoms, said carbon ring atoms optionally being replaced by one or more additional hetero atoms and said ring atoms being optionally substituted by the group consisting of one or more of OR6 and lower alkyl which itself may be optionally substituted by OH; R14 is lower alkyl; R15 and R16 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OH, or alternatively NR15R16 can optionally form a ring having 5-6 ring atoms, said ring atoms comprising, in addition to the nitrogen atom to which R15 and R16 are bonded, carbon ring atoms, said carbon ring atoms optionally being replaced by one or more additional hetero atoms and said ring atoms being optionally substituted by the group consisting of one or more of OR6 and lower alkyl which itself may be optionally substituted by OH; R17 is selected from the group consisting of H, and lower alkyl which optionally may be substituted with a group selected from OH, COOH and NR15R16; and R18 is lower alkyl.