Patent ID: 8299285
Filing Date: 2012-10-30
Classification: A61K,A61P,C07D,G01N

Abstract:
1. A metal complex of formula (III): wherein: M is a Cu; A1 is: n is 0 or an integer of 1 to 5; A2, X and Y are as defined in (i), (ii) and (iii) which follow: (i) A2 is X is N or P and A1 is attached to X via a double bond, or X is O, S, N(R5) or P(R5) and A1 is attached to X via a single bond; and Y is N, O, P, S, N(R5), O(R5), P(R5) or S(R5); or (ii) X is N or P and A1 is attached to X via a double bond, or X is O, S, N(R5) or P(R5) and A1 is attached to X via a single bond; and Y and A2 together represent a moiety of formula (B): wherein the ring that is substituted by L1-R1 is a 5- to 11-membered heterocyclic group; or (iii) X, A2 and Y together represent wherein T is OH, O—, COOH or C(O)O— and rings b and c are aromatic C 6-10 carbocyclic or 5 to 11 membered aromatic heterocyclic groups; X′ is N and A1 is attached to X′ via a double bond, or X′ is N(R5), O, S or P(R5) and A1 is attached to X′ via a single bond; L1 and L1′, which are the same or different, are each independently selected from a covalent bond and a linker group selected from —C(O)—, -alk—C(O)—, —C(O)O—, -alk—C(O)O—, —OC(O)—, -alk—OC(O)—, —O—, -alk—O—, —N(R7)—, -alk—N(R7)—, —N(R7)C(O), -alk—N(R7)C(O)—, —C(O)N(R7), -alk—C(O)N(R7), —C(S)—, -alk—C(S)—, —S—, -alk—S—, —C(S)N(R7)—, -alk—C(S)N(R7)—, —N(R7)C(S)—, -alk—N(R7)C(S)—, —S(O) R1 and R1′, which are the same or different, are each independently selected from hydrogen, Z, L3—Z, L3-alk—Z, —V—L3—Z, —V—L3-alk—Z, alk—V—L3—Z, -alk—V—L3-alk—Z and a substituted or unsubstituted group selected from an alkyl, amino, carbocyclic, cycloalkyl, heterocyclic, -alk-carbocyclic, -alk-cycloalkyl and -alk-heterocyclic group, which group may be further substituted by L3—Z or L3-alk—Z, wherein L3 is as defined above for L1 and L1′, —V— is a linking group of the following formula: wherein P2 and Q2 are independently selected from N, O, P and S and M2 is a metal atom, and Z is a moiety selected from a biologically active molecule, a fluorophore, a cytotoxin, an amino acid, a peptide, an oligopeptide, a polypeptide, a sugar, a group containing a label, a leaving group which is replaceable by a group containing a label, and a complex of Cu, Zn or Ni with a bis(thiosemicarbazone) or a thiosemicarbazone; -alk- is an alkylene, alkenylene or alkynylene group based on an alkyl, alkenyl or alkynyl group; R2 and R2′, which are the same or different, are each independently selected from H, C each R3 is independently selected from H, C each R4 is independently selected from H, C each R5 is independently selected from H, C R7 is H, alkyl or cycloalkyl; each R10 is independently selected from H, C and L2 is —C(O)— or a covalent bond; with the proviso that when X and X′ are both N, Y is S, A1 is (a′) and A2 is (d) then either the moiety represented by L1-R1 or the moiety represented by L1′-R1′ is other than H, unsubstituted alkyl or unsubstituted alkoxy.