Patent ID: 6410740
Filing Date: 2002-06-25
Classification: A61P,C07D

Abstract:
Process for the preparation of oxazolyl compounds of the formula (III-XXIX) in whichX and Y are identical or different and can represent optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic and heterocyclic radicals, carboxyl, acyl, alkoxy, alkoxycarbonyl or cyano or can represent hydrogen, wherein the aromatic and heterocyclic radicals can be substituted by one or more substituents which are chosen from the group which consists of: halogen, formyl, acyl, carboxyl, hydroxyl, alkoxy, aroxy, acyloxy, optionally alkyl-substituted amino, acylamino, aminocarbonyl, alkoxycarbonyl, nitro, cyano, phenyl and alkyl, which can be substituted by one or more substituents selected from the group consisting of: halogen, hydroxyl, amino, carboxyl, acyl, alkoxy, alkoxycarbonyl, heterocyclyl and phenyl, which can be substituted by one or more substitutents selected from the group consisting of: amino, mercaptyl, hydroxyl, formyl, carboxyl, acyl, alkylthio, alkyloxyacyl, alkoxy, alkoxycarbonyl, nitro, cyano, trifluoromethyl, azido, halogen, phenyl and alkyl which is optionally substituted by hydroxyl, carboxyl, acyl, alkoxy and alkoxycarbonyl, and wherein the aliphatic, cycloaliphatic and araliphatic radicals can be substituted by one or more substituents selected from the group consisting of: fluorine, hydroxyl, alkoxy, aroxy, acyloxy, alkyl-substituted amino, acylamino, aminocarbonyl, alkoxycarbonyl and acyl, Z is selected from the group consisting of: hydroxyl, alkoxy, optionally alkyl- and/or halogen-substituted arylalkoxy, optionally alkyl- and/or halogen-substituted aroxy, aroyloxy, acyloxy, alkylthio, optionally alkyl- and/or halogen-substituted arylthio, diacylimido and a group of the formula (III-XXX) in which Y and X have the abovementioned meaning, comprising reacting amides of the formula (III-XXXI) in which Y and X have the abovementioned meaning and Hal represents chlorine or bromine, with compounds of the formula M1+Zâˆ’ or M22+(Zâˆ’)2, in which M1 is an alkali metal, M2 is an alkaline earth metal and Z is as defined above.