Patent ID: 6797712
Filing Date: 2004-09-28
Classification: A61P,C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof, whereinA represents oxygen or sulfur, R1 represents aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl, R2 represents H, C1-12-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl, R3, R4 and R5 each independently of the others represents H, OH, SH, F, Cl, Br, I, â€”CN, NO2, C1-12-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl, â€”SiR6R7R8, â€”(CH2)nâ€”Oâ€”(CH2)mâ€”R9 wherein n=1, 2, 3 or 4 and m=0, 1, 2, 3 or 4, â€”(CH2)oâ€”Spâ€”(CH2)qâ€”R10 wherein o=1, 2, 3 or 4, p=1 or 2 and q=0, 1, 2, 3 or 4, â€”(CH2)râ€”CO2R11 wherein r=0, 1, 2, 3 or 4, â€”(CH2), â€”OCOR12 wherein s=0, 1, 2, 3 or 4, or â€”C(&boxH;O)R13, R6, R7 and R8 each independently of the others represents C1-6-alkyl or phenyl, R9 and R10 each independently of the other represents H, CH3, aryl, heterocyclyl or â€”C(&boxH;O)â€”C1-6-alkyl, â€”C(&boxH;O)â€”(C1-6-alkyl)-aryl or â€”C(&boxH;O)-aryl, R11 represents H, C1-6-alkyl or CH2-phenyl, R12 represents C1-6-alkyl or aryl, R13 represents H, C1-6-alkyl, aryl, heterocyclyl or NR14R15, R14 and R15 each independently of the other represents H, C1-6-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl, or R14 and R15 together form â€”(CH2)kâ€” wherein k=4, 5 or 6, whereinalkyl represents a non-cyclic hydrocarbon radical which is straight-chain or branched and is saturated or unsaturated and is unsubstituted or is monosubstituted or polysubstituted by identical or different substituents, cycloalkyl represents an alicyclic hydrocarbon radical which is saturated or unsaturated and is unsubstituted or is monosubstituted or polysubstituted by identical or different substituents, aryl is a radical selected from the group consisting of heterocyclyl represents a monocyclic or polycyclic radical in which at least one ring contains one hetero atom or 2, 3, 4 or 5 identical or different hetero atoms selected from the group consisting of N, O and S, the radical being saturated or unsaturated and being unsubstituted or monosubstituted or polysubstituted by identical or different substituents, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26 and R27 each independently of the others represents H, OR28, S(O)tR29 wherein t=0, 1 or 2, SO2OR30, F, Cl, Br, I, â€”CN, NO2, C1-12-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, phenyl or (C1-6-alkyl)-phenyl, wherein phenyl is unsubstituted or is monosubstituted or polysubstituted by identical or different substituents, heterocyclyl, (C1-6-alkyl)-heterocyclyl, â€”CO2R31 or â€”NR32R33, R28, R29, R30 and R31 each independently of the others represents H, C1-12-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, phenyl or (C1-6-alkyl)-phenyl, wherein phenyl is unsubstituted or is monosubstituted or polysubstituted by identical or different substituents, heterocyclyl, (C1-6-alkyl)-heterocyclyl or â€”NR34R35, R32 and R33 each independently of the other represents H, C1-6-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, phenyl, (C1-6-alkyl)-phenyl, heterocyclyl or (C1-6-alkyl)-heterocyclyl, or R32 and R33 together form â€”(CH2)hâ€” wherein h=4, 5 or 6, and R34 and R35 each independently of the other represents H, C1-6-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, phenyl, (C1-6-alkyl)-phenyl, heterocyclyl or (C1-6-alkyl)-heterocyclyl, or R34 and R35 together form â€”(CH2)gâ€” wherein g=4, 5 or 6, Provided that (4-methoxy-phenylamino)-thien-2-yl-acetic acid is excluded, wherein the compound is in the form of a racemate, a pure enantiomer, a pure diastereoisomer, a mixture of enantiomers or diastereoisomers in any mixing ratio.