Patent ID: 6201147
Filing Date: 2001-03-13
Classification: C12P

Abstract:
A process for the resolution of esters of arylalkylcarboxylic acids of the general formula I ##STR8##which comprises reacting compounds of the general formula I with an alcohol of the general formula R.sup.6 -OH in the presence of a lipase or esterase to give compounds of the general formulae Ia and II ##STR9##at least one of the compounds of the formulae Ia and II being present in an enantiomeric excess and the substituents and variables in the formulae I, Ia and II having the following meanings:*=optically active centern and m independently of one another are 0 or 1R.sup.1 =hydrogen or methylR.sup.2 =substituted or unsubstituted, branched or unbranched C.sub.1 -C.sub.6 -alkyl-, C.sub.3 -C.sub.6 -cycloalkyl-, aryl- or hetaryl-,R.sup.3, R.sup.4, R.sup.5 independently of one another are hydrogen, substituted or unsubstituted, branched or unbranched C.sub.1 -C.sub.10 -alkyl-, C.sub.2 -C.sub.10 -alkenyl-, C.sub.2 -C.sub.10 -alkynyl-, C.sub.3 -C.sub.10 -cycloalkyl-, C.sub.3 -C.sub.10 -cycloalkyloxy-, C.sub.1 -C.sub.4 -alkylaryl-, C.sub.1 -C.sub.4 -alkylhetaryl-, aryl-, hetaryl-, hydroxyl-, halogen-, cyano-, nitro- or amino-,R.sup.6 =substituted or unsubstituted, branched or unbranched C.sub.1 -C.sub.20 -alkyl-, C.sub.1 -C.sub.20 -alkoxy-, C.sub.2 -C.sub.20 -alkenyl-, C.sub.3 -C.sub.10 -cycloalkyl- or aryl-,and where two adjacent substituents R.sup.3, R.sup.4 and R.sup.5 together can form a further substituted or unsubstituted aromatic, saturated or partially saturated ring having 5 to 6 atoms in X the ring, which can contain one or more heteroatoms selected from O, N or S.