Patent ID: 7534593
Filing Date: 2009-05-19
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A co-crystal of mammalian Glucokinase (SEQ ID NO:1) and a ligand bound to an allosteric site of the Glucokinase, wherein the co-crystal has unit cell dimensions of: a and b are from about 79 Å to about 80.2 Å; c is from about 318 Å to about 325 Å; α and β are 90°; and γ is 120°; and the co-crystal has P6(5)22 symmetry, wherein further the ligand is selected from the group consisting of 3-Cyclopentyl-2-pyridin-4-yl-N-thiazol-2-yl-propionamide, N-(5- Bromo-pyrid in-2-yl)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide, 2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-trifluoromethyl-pyridin-2-yl)- propionamide, (2S)-2-[3-Cyclopentyl-2-(3,4-dichloro-phenyl)-propionylaminol]-thiazole-4- carboxylic acid methyl ester, (2S)-{2-[3-Cyclopentyl-2-(3,4-dichloro-phenyl) -propionylaminol]-thiazol-5-yl}-oxo-acetic acid ethyl ester, (2S)-{3-[3-Cyclopentyl-2-(3,4- dichloro-pheny)-propionyl]-ureidol}-acetic acid methylester, (2S)-1-[3-Cyclopentyl-2- (3,4-dichloro-phenyl)-propionyl]-3-(3-hydroxy-propyl)-urea, and (2S)-{3-[3-Cyclopentyl- 2-(3,4-dichloro-phenyl)-propionyl]-ureido}-acetic acid ethyl ester.