Patent ID: 8865455
Filing Date: 2014-10-21
Classification: B01L,G01N,Y10S

Abstract:
1. An apparatus for investigating a molecule, the apparatus comprising: at least one nanopore provided in a substrate; a first reservoir suitable for receiving a sample including the molecule; a second reservoir separated from the first reservoir by the substrate; means to induce the molecule to move from the first reservoir to the second reservoir via the nanopore; at least one metallic nanostructure disposed around or adjacent to the nanopore facing the second reservoir, the metallic nanostructure producing, by particle plasmon resonance, a localized electromagnetic field around or adjacent to the nanopore facing the second reservoir; means to induce the particle plasmon resonance in the metallic nanostructure; and means to detect fluorescence produced by the interaction of (i) the localized electromagnetic field produced by the metallic nanostructure disposed around or adjacent to the nanopore facing the second reservoir and (ii) the molecule moving from the first reservoir to the second reservoir via the nanopore and in close proximity to the metallic nanostructure.