Patent ID: 6316445
Filing Date: 2001-11-13
Classification: C07D

Abstract:
A compound of the formula ##STR43##whereinR.sub.1 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.2 is hydrogen or a radical chosen from the group consisting of ##STR44##whereinR.sub.3 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl, and --CF.sub.3 ;Ar.sub.1 is a radical chosen from the group consisting of ##STR45##whereinR.sub.4 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, hydroxy, --CF.sub.3, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.5 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;Ar.sub.2 is a radical chosen from the group consisting of ##STR46##whereinR.sub.6 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, --CF.sub.3, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.7 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;X is a radical selected from the group consisting of ##STR47##whereinY is --O-- or --CH.sub.2 --;p is an integer from 1 to 4;R.sub.10 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl;and stereoisomers, and pharmaceutically acceptable salts thereof.