Patent ID: 9074185
Filing Date: 2015-07-07
Classification: A61K,A61P,C12N

Abstract:
1. A method of generating a T cell infusion product for promoting regression of a cancer in a mammal, the method comprising: (i) culturing autologous T cells; (ii) enriching the cultured T cells for CD8+ T cells; (iii) expanding the number of cultured T cells using OKT3 antibody, IL-2, and feeder lymphocytes to provide an expanded number of T cells that are about 19 to about 35 days old; and (iv) providing the expanded number of T cells that are about 19 to about 35 days old as a cell infusion product, wherein (ii) is performed prior to (iii), the T cells have not been screened for specific tumor reactivity, and the T cells recognize an antigen of a cancer.