Patent ID: 8114621
Filing Date: 2012-02-14
Classification: C07D,C07K,G01N,Y10S

Abstract:
1. An immunoassay for detecting lenalidomide in a sample comprising providing a mixture containing said sample, a conjugate of a carrier with a ligand having the formula: wherein B is —C(═O)—CH Y is an organic spacing group; p is an integer from 0 to 1; and X is a terminal functional group capable of binding to a carrier; and an antibody which is selectively reactive with the pharmaceutically active chemotherapeutic drugs selected from the group consisting of lenalidomide and mixtures of lenalidomide with thalidomide and has no substantial cross-reactivity with the non-pharmaceutically active metabolites of said chemotherapeutic drugs, said cross reactivity being less than 10% relative to the antibody's reactivity with said chemotherapeutic drugs and causing the lenalidomide in said sample and said conjugate to bind with said antibody and thereafter measuring the amount of said conjugate in said mixture that is bound or unbound to said antibody, whereby the presence of lenalidomide in said sample can be detected.