Patent ID: 6159455
Filing Date: 2000-12-12
Classification: A61K,A61Q,C07C

Abstract:
A method for protecting the skin or hair from the effects of solar rays which comprises applying to the skin or hair an effective amount of at least one of the dimeric .alpha. alkylstyrene derivatives of the formula I ##STR17## in which the substituents independently of one another have the following meanings:R.sup.1 and R.sup.2 are hydrogen, OH, NH.sub.2, C.sub.1 -C.sub.12 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water, chosen from the group consisting of carboxylate, sulfonate or ammonium radicals;R.sup.3 is COOR.sup.6, COR.sup.6, CONR.sup.6 R.sup.7, CN;R.sup.4 is COOR.sup.6, COR.sup.6, CONR.sup.6 R.sup.7, CN;R.sup.5 is C.sub.1 -C.sub.12 -alkyl,R.sup.6 and R.sup.7 are hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, heteroaryl, optionally substituted;A is O, S, N--R.sup.8 ;B is C.sub.1 -C.sub.12 -alkylene, C.sub.4 -C.sub.12 -cycloalkylene, C.sub.8 -C.sub.22 -aralkylene, C.sub.9 -C.sub.21 -monooxoaralkylene, [--X--].sub.n --Y;R.sup.8 is hydrogen, C.sub.1 -C.sub.12 -alkyl;X is --CH.sub.2 --CH.sub.2 --Z--, --CH.sub.2 --CH.sub.2 --CH.sub.2 --Z--, --CH(CH.sub.3)--CH.sub.2 --Z--, --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --Z--, CH.sub.2 --CH(CH.sub.2 --CH.sub.3)--Z--;Y is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)--CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH(CH.sub.2 --CH.sub.3)--;z is O, S;n is 1 to 150,where, in each case, two of the radicals R.sup.1, R.sup.2 and R.sup.8 together with the aromatic ring to which they are bonded can form a 5- or 6-membered ring.