Patent ID: 6812003
Filing Date: 2004-11-02
Classification: A61K,A61P,C07K

Abstract:
A method for inhibiting cell adhesion mediated drug resistance in a patient in need thereof, said method comprising administering to the patient an effective amount of a peptide that inhibits cell adhesion mediated drug resistance, wherein the peptide comprises the amino acid sequence of SEQ ID NO:6, or a pharmaceutically acceptable salt or variant thereof, and wherein the variant has at least one of the following characteristics: the variant contains one or more hydroxyproline or hydroxylysine; the variant contains an organic acid or amide; the variant contains a C-terminal carboxylate; the variant is esterified; the variant is amidated; the variant has a modified N-terminal amino group; the variant has a side-chain modification or substitution selected from the group consisting of methylation, benzylation, t-butylation, tosylation, and alcoxycarbonylation; the variant has an N-acetyl group; the variant has a C-terminal amide group; or the variant has an amino acid selected from the group consisting of penicillamine, tetramethylene cysteine, pentamethylene cysteine, mercaptopropionic acid, pentamethylene-mercaptopropionic acid, 2-mercaptobenzene, 2-mercaptoaniline, 2-mercaptoproline, ornithine, diaminobutyric acid, aminoapidic acid, m-aminomethylbenzoic acid, and diaminopropionic acid.