Patent ID: 7514466
Filing Date: 2009-04-07
Classification: A61P,C07D

Abstract:
1. A method for purifying a compound of formula I: wherein: A and B are joined to form a ring comprising (i), (ii), or (iii): (i) a carbon-based 3 to 8 membered saturated spirocyclic ring; (ii) a carbon-based 3 to 8 membered spirocyclic ring containing in its backbone one or more carbon-carbon double bonds; or (iii) a 3 to 8 membered heterocyclic ring containing in its backbone one to three heteroatoms selected from the group consisting of O, S and N; the rings of (i), (ii) and (iii) being optionally substituted by from 1 to 4 groups selected from the group consisting of fluorine, C T is absent; Q is O, S, or NR R (iv) halogen; (v) a substituted benzene ring containing the substituents X, Y and Z as shown below: wherein: X is selected from the group consisting of H, halogen, CN, C R R Y and Z are independently selected from the group consisting of H, halogen, CN, NO (vi) a five or six membered ring having in its backbone 1, 2, or 3 heteroatoms selected from the group consisting of O, S, SO, SO R R R R R wherein said method comprises: (a) treating a sample of a compound of formula I which contains greater than about 1% by weight impurities with a base in the presence of a solvent to form a basic salt; and (b) converting said basic salt to a purified form of a compound of formula I by treating said basic salt with water, acid, or heat.