Patent ID: 6107517
Filing Date: 2000-08-22
Classification: A61P,C07C,C07F

Abstract:
A compound Formula I: ##STR21## wherein: n is 1,2or3;R.sup.1 is C.sub.3-12 alkanol, C.sub.2-6 alkenyl, C.sub.5-12 alkenol, heterocyclo, aryl substituted with at least one electron-donating group, --O.sup.2 or --SR.sup.2, where R.sup.2 is C.sub.1-12 alkyl or aryl, or --A--C(O)NR.sup.12 R.sup.13, where A is C.sub.2-15 alkyl or C.sub.4-15 alkenyl and R.sup.12 and R.sup.13 are C.sub.1-6 alkyl;R.sup.3 and R.sup.5 are methyl;R.sup.4 is hydrogen, C.sub.1-6 alkyl or cycloalkyl;R.sup.6 and R.sup.9 are hydrogen or C.sub.1-6 alkyl;R.sup.7 and R.sup.8 are independently hydrogen, halogen, C.sub.1-6 alkyl, optionally substituted phenyl, optionally substituted benzyl, or heteroaryl; with the proviso that R.sup.7 and R.sup.8 cannot both be hydrogen;R.sup.10 is hydrogen, C.sub.1-6 alkyl, cycloalkyl, or acyl; andR.sup.11 is hydrogen, C.sub.1-6 alkyl, or cycloalkyl; and the pharmaceutically acceptable salts thereof.