Patent ID: 6040319
Filing Date: 2000-03-21
Classification: A61P,C07C,C07D

Abstract:
A process for synthesizing a compound of the formula I: ##STR26## wherein: 0-2 R groups are present;each R, R' and R"" independently represents C.sub.1-10 alkyl, C.sub.6-10 aryl, aralkyl, halo, --S(O).sub.m H, --S(O).sub.m C.sub.1-6 alkyl, --S(O).sub.m aryl, nitro, amino, C.sub.1-6 alkylamino, di-C.sub.1-6 alkylamino, --S(O).sub.m NH.sub.2, --S(O).sub.m NHC.sub.1-6 alkyl, --S(O).sub.m NHC(O)CF.sub.3 and cyano,the alkyl and aryl groups, and the alkyl and aryl portions of aralkyl, --S(O).sub.m C.sub.1-6 alkyl, --S(O).sub.m aryl, C.sub.1-6 alkylamino, di-C.sub.1-6 alkylamino and --S(O).sub.m NHC.sub.1-6 alkyl being optionally substituted with 1-3 groups selected from --S(O).sub.m C.sub.1-6 alkyl, --CN, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylamino, di-C.sub.1-6 alkylamino, --S(O).sub.m NH.sub.2, --S(O).sub.m NHC.sub.1-6 alkyl, --S(O).sub.m NHC(O)CF.sub.3 and aryloxy;Y is N;and m is 0, 1 or 2,comprising reacting a compound of formula II: ##STR27## wherein R.sup.2 through R.sup.5 each independently represent C.sub.1-6 alkyl, aryl or aralkyl, and X- represents a suitable counterion,with a compound of the formula III: ##STR28## wherein R, R' and Y are as previously defined, in the presence of a base to produce a compound of formula I.