Patent ID: 6245809
Filing Date: 2001-06-12
Classification: C07C,C07D

Abstract:
A compound having the formula: ##STR45##wherein:Y is selected from the group consisting of --COOH, --PO.sub.3 H.sub.2, --SO.sub.3 H and --COOR.sup.4 ; where R.sup.4 is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-8 alkylaryl, aryl-C.sub.1-8 alkyl, C.sub.1-8 alkyloxycarbonyloxy-C.sub.1-8 alkyl, aryloxycarbonyloxy-C.sub.1-8 alkyl, C.sub.1-8 alkyloxycarbonyloxyaryl, C.sub.1-8 alkylcarbonyloxy-C.sub.1-8 alkyl, arylcarbonyloxy-C.sub.1-8 alkyl and C.sub.1-8 alkylcarbonyloxyaryl;A is selected from the group consisting of C.sub.6-12 alkyl, C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.0-8 -alkyl, C.sub.0-8 alkyl-CO--NR.sup.5 --C.sub.0-8 -alkyl, C.sub.0-8 alkyl-O-C.sub.0-8 alkyl, C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.1-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl, C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.1-8 alkyl-CO--NR.sup.5 --C.sub.0-8 alkyl, C.sub.0-8 alkyl-CO-C.sub.1-8 alkyl-CO--NR.sup.5 --C.sub.0-8 alkyl, C.sub.0-8 alkyl-CO-C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl, C.sub.0-8 alkyl-O-C.sub.2-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl, C.sub.0-8 alkyl-S-C.sub.0-8 alkyl, C.sub.0-8 alkyl-S(O.sub.n)-C.sub.0-8 alkyl, C.sub.0-8 alkyl-S-C.sub.2-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl, C.sub.0-8 alkyl-S(O.sub.n)-C.sub.2-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl, C.sub.0-8 alkyl-S-C.sub.0-8 alkyl-CO--NR.sup.5 --C.sub.0-8 alkyl, C.sub.0-8 alkyl-S(O.sub.n)-C.sub.1-8 alkyl-CO--NR.sup.5 --C.sub.0-8 alkyl, C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.0-8 alkyl-S-C.sub.0-8 alkyl, C.sub.0-8 alkyl-NR.sup.5 --CO-C.sub.1-8 alkyl-S(O.sub.n)-C.sub.0-8 alkyl, C.sub.0-8 alkyl-CO--NR.sup.5 --C.sub.2-8 alkyl-S-C.sub.0-8 alkyl, C.sub.0-8 alkyl-CO--NR.sup.5 --C.sub.2-8 alkyl-S(O.sub.n)-C.sub.0-8 alkyl, C.sub.0-8 alkyl-NR.sup.5 --C.sub.0-8 alkyl-CO--NR.sup.5 --C.sub.0-8 alkyl, C.sub.0-8 alkyl-SiR.sup.7 R.sup.8 -C.sub.0-8 alkyl, C.sub.0-8 alkyl-SiR.sup.7 R.sup.8 -C.sub.0-8 alkyl-NR.sup.6 --CO-C.sub.0-8 alkyl, and C.sub.0-8 alkyl-SiR.sup.7 R.sup.8 -C.sub.0-8 alkyl-CO--NR.sup.6 --C.sub.0-8 alkyl; where R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of H and C.sub.1-6 alkyl; and where n=1 or 2;Z is selected from the group consisting of --NH--C(NR.sup.9 R.sup.10).dbd.NR.sup.11, --NH--C(R.sup.9).dbd.NR.sup.11, and --C(NR.sup.9 R.sup.10).dbd.NR.sup.11 ; where R.sup.9, R.sup.10 and R.sup.11 are independently selected from the group consisting of H, C.sub.1-6 alkyl, aryl-C.sub.1-3 alkyl and aryl;R.sup.1 is H;R.sup.2 is selected from the group consisting of --SO.sub.m -aryl, --SO.sub.m -C.sub.1-10 alkyl and --SO.sub.m -heteroaryl, where m=1-2;R.sup.3 is selected from the group consisting of H, C.sub.1-8 alkyl, aryl, and C.sub.1-8 alkylaryl; and all pharmaceutically-acceptable stereoisomers, salts, hydrates, solvates and prodrug derivatives thereof.