Patent ID: 6221871
Filing Date: 2001-04-24
Classification: C07C,C07D

Abstract:
A compound of the formula: ##STR24##or the pharmaceutically acceptable salt thereof wherein:S and V are the same or different and represent hydrogen, halogen, hydroxy, phenyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;G and K are the same or different and represent N or CR' where R' is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms or straight or branched lower alkoxy having 1-6 carbon atoms;R is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms;R.sub.1, X, Y, Z and T are the same or different and represent hydrogen, halogen, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched lower alkoxy having 1-6 carbon atoms or SO.sub.2 R.sub.4 where R.sub.4 is straight or branched chain lower alkyl having 1-6 carbon atoms or where R.sub.4 is NH.sub.2 or NHCH.sub.3 ;R.sub.2 and R.sub.3 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, arylalkyl; orNR.sub.2 R.sub.3 together represent 2-(1,2,3,4-tetrahydroisoquinolinyl), either unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched lower alkoxy having 1-6 carbon atoms; orNR.sub.2 R.sub.3 represents: ##STR25##where R.sub.5 is phenyl, either unsubstituted or mono or disubstituted by either halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; orNR.sub.2 R.sub.3 together represent ##STR26##where W is N or CH; andR6 is phenyl, benzyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; and n is 1, 2 or 3;provided that(a) R.sup.5 or R.sup.6 are not phenyl when K is CR', G is N and NR.sub.2 R.sub.3 represents ##STR27##(b) R.sup.6 is not phenyl when G and K are N and NR.sub.2 R.sub.3 represent ##STR28##(c) R.sub.2 and R.sub.3 are not lower alkyl when R.sub.1, X, Y, Z and T are hydrogen, K and G are CH, S is hydrogen and V is hydroxy.