Patent ID: 8017104
Filing Date: 2011-09-13
Classification: A61K,C07D,C09B,G01N,Y10S

Abstract:
1. A water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye compound having a Stokes shift of greater than 50 nm and represented by at least one of the following five general formulae: wherein: R1 and R2 are substituted alkyl groups and may together form a ring and at least one of R1 or R2 comprises a linking group selected from the group comprising COOH, NH2, maleimide, thiol, isocyanate, isothiocyanate, disulfide, alkynyl, azidoyl, or trialkoxysilane, wherein the linking group may form part of the ring; A is Ra—C—Rb, wherein Ra and Rb are substituted or unsubstituted alkyl groups; Rc is hydrogen or SO3-, aryl, alkyl, alkoxy, or halogen; Rd is alkyl or (CH2)nSO3- where n=2 to 4, wherein: R1 and R2 are substituted alkyl groups and are together capable of forming a ring, and at least one of R1 or R2 comprises a linking group selected from the group comprising COOH, NH2, maleimide, thiol, isocyanate, isothiocyanate, disulfide, alkynyl, azidoyl, or trialkoxysilane, wherein the linking group may form part of the ring; A is Ra—C—Rb, wherein Ra and Rb are substituted or unsubstituted alkyl groups; Rc is hydrogen or SO3-, aryl, alkyl, alkoxy, or halogen; Rd is alkyl or (CH2)nSO3- where n=2 to 4, wherein: A is Ra—C—Rb; R3, R4, Ra, and Rb are substituted or unsubstituted alkyl groups capable of joining together to form a ring; R6 is a SO3-; R5 is a substituted alkyl group and at least one of the substituents is selected from the group comprising OH, NH2, COOH, maleimide, thiol, isocyante, isothiocyanate, disulfide, alkynyl, azidoyl, or trialkoxysilane; wherein: A is Ra—C—Rb; R3, R4, Ra, and Rb are substituted or unsubstituted alkyl groups capable of joining together to form a ring; at least one of Rc and Rc′ is a SO3-; R5 is a substituted alkyl group and at least one of the substituents is selected from the group consisting of OH, NH2, COOH, maleimide, thiol, isocyante, isothiocyanate, disulfide, alkynyl, azidoyl, or trialkoxysilane; Rc is hydrogen or SO3-, aryl, alkyl, alkoxy, or halogen; and wherein: A is Ra—C—Rb; R3, R4, Ra, and Rb are substituted or unsubstituted alkyl groups capable of joining together to form a ring; R7 is a COOH; R5 is substituted alkyl and contains a SO3- group.