Patent ID: 6211219
Filing Date: 2001-04-03
Classification: C07D

Abstract:
A compound of formula I, or a pharmaceutically acceptable salt thereof: ##STR21##whereinZ represents an optionally substituted triazole wherein the substituent is selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, aryl aryl(C1-6) alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, di(C1-6)alkyamino halogen, cyano and trifluoromethylE represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;Q represents a straight or branched alkylene chain containing from 1 to 6 carbon atoms, optionally substituted in any position by one or more substituents selected from fluoro and hydroxy;T represents CH;U represents C--R.sup.2 ;V represents N--R.sup.3 ;R.sup.1 represents aryl(C.sub.1-6)alkyl or tetrahydronaphthyl, any of which groups may be optionally substituted wherein the substituent is selected from halogen, cyano, trifluoromethyl, hydroxy, keto,C1-6 alkoxy, C1-6 alkylthio, C2-6 alkoxycarbonyl, C2-6 alkylcarbonyl, C1-6 alkylsulphonyl, arylsulphonyl, amino, C1-6 alkylamino, di(C1-6)alkylamino, di(C1-6)alkylaminomethyl, C2-6 alkylcarbonylamino, arylcarbonylamino, C2-6 alkoxycarbonylamino, N--(C1-6)alkyl-N--(C2-6) alkoxycarbonylamino, C1-6 alkylsulphonylamino, arylsulphonylamino, C1-6 alkylsulphonylaminomethyl, aminocarbonylamino, C1-6 alkylaminocarbonylamino, di(C1-6)alkylaminocarbonylamino, mono or diarylaminocarbonylamino, aminocarbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, aminosulphonyl, C1-6 alkylaminosulphonyl, di(C1-6)alkylaminosulphonyl, aminosulphonylmethyl, C1-6 alkylaminosulphonylmethyl and di(C1-6)alkylaminosulphonylmethyl; andR.sup.2, R.sup.3 and R.sup.7 independently represent hydrogen or C.sub.1-6 alkyl.