Patent ID: 6197314
Filing Date: 2001-03-06
Classification: A61K

Abstract:
A solid oral administration form comprising a pharmacologically active ingredient homogeneously blended with an extraction-preventing composition, said extraction-preventing composition consisting essentially of a surfactant, and a fat or gel former in a weight ratio of from 95:1 to 1:95, wherein said extraction-preventing composition is blended with said pharmacologically active ingredient in an amount of 1-300:1, such that said solid oral administration form produces a creamy emulsion on extraction with organic solvent whereby no more than 30 percent of said active ingredient is contained in said organic solvent;said surfactant being an alkylsulfonate compound according to the formula RO--CO--CH.sub.2 --SO.sub.3 Na wherein R=C.sub.6-16 alkyl;said fat being selected from the group consisting of palm oil, hardened palm oil, apricot kernel oil, cottonseed oil, carnauba wax, glycerol monosteorate, monoglyceride, diglyceride, cetyl alcohol, cetyl palmitate, hard fat, coconut oil and arachis oil; andsaid gel former being selected from the group consisting of xanthan, alginic acid, alkali metal alginate, gum arabic, agar, ghatti gum, karaya gum, tragacanth, guar gum, locust bean gum, pectin, chitin, amylopectin, gelatin, hydroxymethylpropylcellulose, methylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, ethylcellulose, sodium carboxymethylcellulose, sodium carboxyethylcellulose, montmorillonite, polyacrylic acid, methyl ester of polyacrylic acid, ethyl ester of polyacrylic acid, sodium carboxymethyl starch and sodium carboxyethylstarch.