Patent ID: 8835469
Filing Date: 2014-09-16
Classification: A61P,C07D

Abstract:
1. Compounds having the structure of Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, or diastereomers thereof, wherein X═O, CH 2 , S; Y═O, CH 2 , CR 1 R 2 , NR 1 , NCOR 1 ; HET-1 is a 5- or 6-membered, C-linked heteroaryl ring containing a nitrogen atom in 2-position relative to the amide nitrogen to which the ring is attached and optionally containing 1 or 2 further ring heteroatoms independently selected from O, N and S, which ring is optionally substituted on available carbon, nitrogen and/or sulfur atom with one or more R 3 ; Ring ‘Z’ is selected from phenyl or ‘HET-3’, wherein ‘HET-3’ is a 5- or 6-membered heteroaryl or heterocyclic ring containing 1, 2 or 3 hetero atoms independently selected from O, S and N and wherein either the phenyl or the ‘HET-3’ independently is further substituted with one or more of R 3 ; ‘Het-2’ is selected from the following cyclic groups R