Patent ID: 6448290
Filing Date: 2002-09-10
Classification: A61P,C07C,C07D

Abstract:
A sulfonamide or carbonamide derivative of the formula (I) (wherein each, independently, is a C5-15 carbocyclic ring,Z1 is â€”COR1, â€”C1-4 alkylene-COR1, â€”CH&boxH;CHâ€”COR1, â€”Câ‰¡COR1, or â€”Oâ€”C1-3 alkylene-COR1, (wherein, R1 is hydroxy, C1-4 alkoxy or formulaNR6R7 (wherein, R6 and R7 each, independently, is H or C1-4 alkyl), orâ€”C1-5 alkylene-OH, Z2 is H, C1-4 alkyl, C1-4 alkoxy, nitro, halogen, trifluoromethyl, trifluoromethoxy, hydroxy or COR1 (wherein R1 is as defined hereinbefore)), Z3 is single bond or C1-4 alkylene, Z4is SO2or CO, Z5 is (1) C1-8 alkyl, C2-8 alkenyl, or C2-8 alkynyl, (2) phenyl, C3-7 cycloalkyl, or 5-7 membered heterocyclic ring containing one or two oxygen, sulfur or nitrogen atom(s), or (3) C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl substituted by phenyl or C3-7 cycloalkyl (phenyl, C3-7 cycloalkyl and 5-7 membered heterocyclic ring containing one or two oxygen, sulfur or nitrogen atom(s) mentioned in the above (2) and (3) may be substituted by 1-5 of R5 (wherein R5 (if two or more R5, each independently) is H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, nitro, halogen trifluoromethyl, trifluoromethoxy or hydroxy)), R2 is alkoxy or C(O)NH, R3 is H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, nitro, halogen, trifluoromethyl, trifluoromethoxy, hydroxy or hydroxymethyl, R4is (1) H, (2) C1-18 alkyl, C2-8 alkenyl, or C2-8 alkynyl, (3) C1-6 alkyl substituted by one or two substituent(s) selected from the group consisting of COOZ8, CONZ9Z0, and OZ8 (wherein Z8, Z9 and Z10 each, independently, is H or C1-4 alkyl) and C1-4 alkoxy-C1-4 alkoxy, (4) C3-7 cycloalkyl, or (5) C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl substituted by phenyl or C3-7 cycloalkyl (phenyl and C3-7 cycloalkyl mentioned in the above (4) and (5) may be substituted by 1-5 of R5 (wherein R5 is as defined hereinbefore)), and n and t each, independently, is an integer of 1-4, with the proviso that (1) R2 and Z3 should be connected at the 1- or 2-position of (2) when â€ƒis a benzene ring and (Z2)t is other than COR1, Z1 should be connected at the 3- or 4-position of the benzene ring and (3) the compounds wherein are excluded, or a non-toxic salt thereof.