Patent ID: 7807182
Filing Date: 2010-10-05
Classification: A61P,C07K,G01N

Abstract:
1. An antigenic composition useful for early detection of M. tuberculosis (Mtb) disease or infection or for immunizing a subject against Mtb infection, comprising (a) a peptide selected from the group consisting of:  with the proviso that said composition is not the full length protein GlcB, the sequence of which is SEQ ID NO:106, or MPT51, the sequence of which is SEQ ID NO:107; (b) a conservative amino acid substitution variant of the peptide of (a) which retains reactivity with antibodies specific for (i) GlcB in the case of peptides (1)-(6) or (8)-(23) or (ii) MPT51 in the case of peptide (7); or (c) a combination of two or more of any of said peptides (1)-(23) of (a) or a combination of two or more of any of said variants of (b), or a combination of any one or more of said peptides of (a) and any one or more of said variants of (b).