Patent ID: 7563771
Filing Date: 2009-07-21
Classification: A61K,A61P,C07K

Abstract:
1. A synthetic apolipoprotein-E mimicking polypeptide comprising the amino acid sequence X-Y-Arg-Arg-Y-Y-X-X-Y-Y-Arg-Y-Y-Arg (SEQ ID NO: 210) wherein X is glycine, threonine, serine or alanine, wherein Y is selected from the group consisting of phenylalanine, tyrosine, leucine, isoleucine, valine, and tryptophan, wherein the polypeptide comprises an acetyl group at the N-terminus and an amide group at the C-terminus, wherein the polypeptide is capable of forming an amphipathic α helical structure, and wherein the polypeptide is also capable of binding lipoproteins.