Patent ID: 6433182
Filing Date: 2002-08-13
Classification: A61K,A61P,C07C,C07D,Y10S

Abstract:
A method of treating a sexual dysfunction in a female individual in need thereof comprising administering to the female individual a therapeutically effective amount of at least one compound having structure II and a pharmaceutically acceptable carrier to treat the sexual dysfunction, wherein the compound having structure II is: wherein D1 is a hydrogen or D; with the proviso that D1 must be D if there is no other D in the compound;D is (i) â€”NO, (ii) â€”NO2, (iii) â€”C(Rd)â€”Oâ€”C(O)â€”Yâ€”Zâ€”(C(Re)(Rf))pâ€”Tâ€”Q, wherein Rd is a hydrogen, a lower alkyl, a cycloalkyl, an aryl, an arylalkyl, or a heteroaryl; Y is oxygen, sulfur, carbon or NRi wherein Ri is a hydrogen or a lower alkyl; Re and Rf are each independently a hydrogen, a lower alkyl, a haloalkyl, a cycloalkyl, an alkoxy, an aryl, a heteroaryl, an arylalkyl, an amino, an alkylamino, a dialkylamino, an amido, an alkylamido, a carboxylic acid, a carboxylic ester, a carboxamido, a carboxy or â€”Tâ€”Q; or Re and Rf taken together are a carbonyl, a heterocyclic ring, a cycloalkyl or a bridged cycloalkyl; p is an integer from 1 to 10; T is independently a covalent bond, oxygen, sulfur or nitrogen; Z is a covalent bond, a lower alkyl, a haloalkyl, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, a heteroalkyl, an arylheterocyclic ring or (C(Re)(Rf))p, and Q is â€”NO or â€”NO2; (iv) â€”C(O)â€”Yâ€”Zâ€”(Gâ€”(C(Re)(Rf))qâ€”Tâ€”Q)p wherein G is a covalent bond, â€”Tâ€”C(O)â€”, â€”C(O)â€”Tâ€” or T, wherein q is an integer from 0 to 5, and wherein Re, Rf, p, Q, Z, Y and T are as defined above, or (v) â€”Pâ€”Zâ€”(Gâ€”(C(Re)(Rf))qâ€”Tâ€”Q)p, wherein P is a carbonyl, a phosphoryl or a silyl, and wherein Re, Rf, p, q, Q, T, Z and G are as defined above.