Patent ID: 8273891
Filing Date: 2012-09-25
Classification: A61P,C07D

Abstract:
1. A compound according to Formulas I, II, III, or IV: wherein A is X is O or S; X R′ is H, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, or cycloalkylalkyl having 4 to 7 carbon atoms; R R two R R R R R R Ar is an aryl group having 6 to 10 carbon atoms which is unsubstituted or substituted one or more times by alkyl having 1 to 8 C atoms, alkoxy having 1 to 8 C atoms, halogen, dialkylamino wherein the alkyl portions each have 1 to 8 C atoms, amino, cyano, hydroxyl, nitro, halogenated alkyl having 1 to 8 C atoms, halogenated alkoxy having 1 to 8 C atoms, hydroxyalkyl having 1 to 8 C atoms, hydroxyalkoxy having 2 to 8 C atoms, alkenyloxy having 3 to 8 C atoms, alkylthio having 1 to 8 C atoms, alkylsulphinyl having 1 to 8 C atoms, alkylsulphonyl having 1 to 8 C atoms, monoalkylamino having 1 to 8 C atoms, cycloalkylamino wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, hydroxyl, amino, monoalkylamino having 1 to 4 carbon atoms, dialklyamino in which each alkyl group has 1 to 4 carbon atoms, or combinations thereof, aryloxy wherein the aryl portion has 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, hydroxy, alkoxy having 1 to 8 carbon atoms, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino having 1 to 8 carbon atoms, dialkylamino in which each alkyl group has 1 to 8 carbon atoms, hydroxyalkyl having 1 to 8 carbon atoms, hydroxyalkoxy having 1 to 8 carbon atoms, carboxy, cyano, acyl, alkoxycarbonyl wherein the alkoxy group has 1 to 8 carbon atoms, alkylthio, alkylsulphinyl having 1 to 8 carbon atoms, alkylsulphonyl having 1 to 8 carbon atoms, phenoxy, acyloxy, or combinations thereof, arylthio wherein the aryl portion has 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, hydroxy, alkoxy having 1 to 8 carbon atoms, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino having 1 to 8 carbon atoms, dialkylamino in which each alkyl group has 1 to 8 carbon atoms, hydroxyalkyl having 1 to 8 carbon atoms, hydroxyalkoxy having 1 to 8 carbon atoms, carboxy, cyano, acyl, alkoxycarbonyl wherein the alkoxy group has 1 to 8 carbon atoms, alkylthio, alkylsulphinyl having 1 to 8 carbon atoms, alkylsulphonyl having 1 to 8 carbon atoms, phenoxy, or acyloxy, or combinations thereof, cycloalkyloxy wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, hydroxyl, amino, monoalkylamino having 1 to 4 carbon atoms, dialklyamino in which each alkyl group has 1 to 4 carbon atoms, or combinations thereof, sulfo, sulfonylamino, acylamido, acyloxy or combinations thereof; Het is a heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl having 6 to 10 carbon atoms which is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, hydroxy, alkoxy having 1 to 8 carbon atoms, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino having 1 to 8 carbon atoms, dialkylamino in which each alkyl group has 1 to 8 carbon atoms, hydroxyalkyl having 1 to 8 carbon atoms, hydroxyalkoxy having 1 to 8 carbon atoms, carboxy, cyano, acyl, alkoxycarbonyl wherein the alkoxy group has 1 to 8 carbon atoms, alkylthio, alkylsulphinyl having 1 to 8 carbon atoms, alkylsulphonyl having 1 to 8 carbon atoms, phenoxy, acyloxy, or combinations thereof, alkyl having 1 to 8 C atoms, alkoxy having 1 to 8 C atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, halogenated alkoxy having 1 to 8 C atoms, cycloalkoxy having 3 to 7 carbon atoms, cycloalkylalkoxy having 4 to 7 carbon atoms, alkoxyalkyl having 2 to 8 carbon atoms, alkyl(halogenated alkyl)amino wherein each alkyl group has 1 to 8 C atoms, di(halogenated alkyl)amino wherein each alkyl group has 1 to 8 C atoms, (halogenated alkyl)amino having 1 to 8 C atoms, cyano, halogenated alkyl having 1 to 8 carbon atoms, nitro, oxo, OH, alkoxycarbonylalkyl having 3 to 8 carbon atoms, amino, monoalkylamino having 1 to 8 C atoms, dialkylamino wherein each alkyl group has 1 to 8 C atoms, SO Carbo is a partially unsaturated carbocyclic group having 5 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 C atoms, alkoxy having 1 to 8 C atoms, hydroxy, nitro, cyano, oxo, or combinations thereof; and R and pharmaceutically acceptable salts or N-oxides thereof, or pharmaceutically acceptable salts of N-oxides thereof, wherein said compound can also be in the form of a polymorph, wherein if said compound exhibits chirality it can be in the form of a mixture of enantiomers or a mixture of diastereomers, or can be in the form of a single enantiomer or a single diastereomer, and wherein at least one R