Patent ID: 8211404
Filing Date: 2012-07-03
Classification: A61K

Abstract:
1. A method of obtaining in vivo or in vitro images comprising the steps of: (a) administering a diagnostic formulation comprising one or more iodinated contrast agents comprising one or more mobile protons able to exchange with bulk water, to an individual or to an organ or other body part or tissue of the individual, (b) imaging, with magnetization transfer MRI techniques, by irradiating the mobile protons of the iodinated contrast agent with a radiofrequency field tuned on the resonance frequency of the concerned protons and inducing, through chemical exchange, saturation transfer to the bulk water signal, to obtain an image of an organ or other body part or tissue of the individual in which the saturation of the water signal causes a decrease in the water proton signal intensity, and (c) recording the image, wherein said iodinated contrast agents comprise at least one amido function and are iodinated aromatic compounds having a triiodinated aromatic ring bearing at the remaining positions straight or branched, functionally substituted organic residues or compounds comprising at least two triiodinated aromatic residues mutually covalently linked at one of the positions, either directly or through a straight or branched, functionally substituted organic residue, said aromatic ring being further substituted at the remaining positions by straight or branched, functionally substituted organic residues and in which the organic residues and the triiodinated aromatic ring are linked by amido functions.