Patent ID: 6417180
Filing Date: 2002-07-09
Classification: A61K,A61P,C12N

Abstract:
A compound having the formula:Aâ€”(Lâ€”B)m whereinA is a polymerase III active site-binding moiety selected from the group consisting of: in which each of R1 and R2, independently, is hydrogen, C1-3 alkyl, C1-3 haloalkyl, or â€”Lâ€”B; each of R3 and R4, independently, is hydrogen, C1-3 alkyl, halo, C1-3 haloalkyl, or â€”Lâ€”B; m is 1 or 2; and n is 0, 1, or 2; provided that at least one of R1, R2, R3, and R4, is â€”Lâ€”B;L is a linker; and B is a zinc finger-reactive moiety selected from the group consisting of: wherein each of Ra and Rb, independently, is hydrogen, C1-6 alkyl, phenyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, amine, or â€”Lâ€”A; and p is 1, 2, 3, or 4; provided that either one of Ra and Rb is â€”Lâ€”A, and Ra and Rb are not â€”Lâ€”A simultaneously;or a salt thereof.