Patent ID: 8293318
Filing Date: 2012-10-23
Classification: A61F,A61L

Abstract:
1. A method comprising the steps of: a. providing a device body; b. disposing a reservoir layer composition comprising a bioactive agent, a hydrophobic polymer that, if the bioactive agent is also hydrophobic, is more hydrophobic than the bioactive agent, and a first hydrophobic solvent over the device body; c. removing the first hydrophobic solvent from the composition to form a reservoir layer; d. repeating steps b. and c. until a desired reservoir layer thickness and bioactive agent concentration is achieved; e. determining a release rate curve for the bioactive agent from the reservoir layer; and f. selecting a desired release rate, the desired release rate being either slower or faster than the release rate determined in step e.; and on at least one subsequent occasion, executing steps a. to e. subject to one or more modifications based on the selection of step f.; wherein if the desired release rate selected is slower, at least one of the one or more modifications is selected from the group consisting of: and wherein if the desired release rate selected is faster, at least one of the one or more modifications is selected from the group consisting of: