Patent ID: 7279179
Filing Date: 2007-10-09
Classification: A61K,A61P,B82Y

Abstract:
1. A composition for administration of 7-(2-(N-isopropylamino)ethyl)-(20S)-camptothecin, comprising liposomes composed of at least about 20 mole percent of a vesicle-forming lipid derivatized with a hydrophilic polymer chain, said liposomes having an inside/outside ion gradient effective to retain the 7-(2-(N-isopropylamino)ethyl)-(20S)-camptothecin within the liposomes; and entrapped in the liposomes, the 7-(2-(N-isopropylamino)ethyl)-(20S)-camptothecin at a concentration of at least about 0.20 μmole drug per mole lipid, wherein said liposome composition provides at least a four-fold increase in anti-tumor activity over the anti-tumor activity of the drug in free-form.