Patent ID: 6569456
Filing Date: 2003-05-27
Classification: A61K

Abstract:
A chronotherapeutic osmotic device comprising:a) a core comprising a therapeutically effective amount of diltiazem (DZ) and at least one osmotic agent or osmopolymer, wherein the core provides a controlled release of diltiazem; b) a semipermeable membrane surrounding the core and having a passageway there through; and c) an external coat comprising a therapeutically effective amount of an angiotensin converting enzyme (ACE) inhibitor or diuretic, wherein the external coat provides a rapid release of the ACE inhibitor or diuretic; wherein, d) at least 70% of the DZ is released in a controlled manner within 20 hours, and at least about 45% of the ACE inhibitor is released within 180 minutes or at least about 75% of the diuretic is released within about 180 minutes after exposure of the osmotic device to an aqueous environment; and e) initial release of the DZ and, optionally, ACE inhibitor or diuretic is delayed for a period of at least about 1.5 hour after exposure of the osmotic device to an aqueous environment.