Patent ID: 8168610
Filing Date: 2012-05-01
Classification: A61K,A61P,C12N

Abstract:
1. A method for inducing apoptosis in glioma cells comprising contacting said cells with an antisense oligonucleotide, wherein substantially all of the antisense oligonucleotide is complementary to a portion of a gene encoding IGFBP-2 and substantially all of the antisense oligonucleotide is also complementary to a gene encoding IGFBP-5, and wherein the antisense oligonucleotide is of sufficient length to act as an antisense inhibitor of IGFBP-2 and IGFBP-5, and wherein the antisense oligonucleotide consists of the sequence as set forth in any one of Seq. ID Nos. 1 to 7.