Patent ID: 6440974
Filing Date: 2002-08-27
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein:a represents N or NOâ€”; R1 and R3 are the same or different halo atom; R2 and R4 are selected from H and halo, provided that at least one of R2 and R4 is H; the dotted line (---) represents an optional bond; X is N, and the optional bond to X is absent; T is a substituent selected from: wherein:A represents â€”(CH2)bâ€”; B represents â€”(CH2)dâ€”; b and d are independently selected from: 0, 1, 2, 3, or 4 such that the sum of b and d is 3 or 4; and Y is selected from: O, S, SO, or SO2; wherein:D represents â€”(CH2)eâ€”; E represents â€”(CH2)fâ€”; e and f are independently selected from: 0, 1, 2, or 3 such that the sum of e and f is 2 or 3; and Z is O; wherein:F represents â€”(CH2)gâ€”; G represents â€”(CH2)hâ€”; U represents â€”(CH2)iâ€”; h represents 1, 2, or 3; g and i are independently selected from: 0, 1 or 2 such that the sum of h, g and i is 2 or 3; and V and W are independently selected from O, S, SO, or SO2; wherein:the dotted line (---) represents an optional bound; k is 1 or 2 such that when the optional bond is present k represents 1, and when the optional double bond is absent then k represents 2; R5, R6, R7 and R8 are the same alkyl or R5 and R7 are the same alkyl and R6 and R8 are H; wherein:the dotted lines (---) represent optional bonds 1 and 2 such that optional bonds 1 and 2 are both present, or optional bonds 1 and 2 are both absent; Y represents O, S, SO, or SO2; wherein:Y represents O, S, SO, or SO2; wherein:R9 is selected from: â€”CN, â€”CO2H, or â€”C(O)N(R10)2; Y represents O; each R10 is the same or diferent alkyl group; wherein:I represents â€”(CH2)mâ€”; m represents 2 or 3; Y represents O, S, SO, or SO2; and R11 represents alkyl.