Patent ID: 7385083
Filing Date: 2008-06-10
Classification: A61K,A61P

Abstract:
1. A method of treatment of hypertension, tonic bladder, disturbances of peripheral circulation, airway hyperresponsiveness, sensory neuron hypersensitivity, central spasm or ischemic central nervous system disorder, which comprises administering a compound, or a physiologically acceptable salt thereof as an active ingredient, wherein the compound is represented by the formula: wherein R 12 is acyl, carboxyl, hydroxamate, sulfo, carbamoyl, sulfonamide or nitrile; wherein R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 and R 21 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde or nitrile; or R 20 and R 21 may be bonded to each other to form oxo.