Patent ID: 6328972
Filing Date: 2001-12-11
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A pharmaceutical composition for use in inducing a class I-restricted CTL response in a mammal, comprising a pharmaceutically acceptable excipient and a particulate-protein complex in an amount effective to induce a class I-restricted CTL response to a protein antigen in a mammal, in which the particulate protein complex comprises a particulate component having an average diameter ranging in size from about 1 .mu.m to about 6 .mu.m, wherein the particulate component has an outer surface linked to a non-replicating protein antigen derived from a pathogenic organism and wherein the protein antigen is taken up, processed and presented in association with MHC class I molecules by an antigen presenting cell, with the proviso that the particulate component is not a prokaryotic or eukaryotic cell, a micellar, multimicellar, or liposome vesicle, alum, or composed of detergents or lipids.