Patent ID: 6537991
Filing Date: 2003-03-25
Classification: A61K,A61P

Abstract:
A method of treating a peripheral neuropathic pain in a warm-blooded animal requiring such treatment which comprises administering to said animal a therapeutically effective amount of an EP1-type prostaglandin receptor antagonist selected from the group consisting of:6-[N-(2-benzyloxy-5-bromobenzyl)-N-ethylamino]pyridazine-3-carboxylic acid; 6-[N-(5-bromo-2-(2-methylprop-2-en-1-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid; N-propanesulphonyl-6-[N-(5-bromo-2-(cyclopropylmethoxy)benzyl-N-ethylamino]pyridazin-3-carboxamide; N-(3,5-dimethylisoxazol-4-ylsulphonyl)-6-[N-(5-chloro-2-(2-methylpropoxy)benzyl)-N-ethylamino]pyridazin-3-carboxamide; 6-[N-(5-bromo-2-(cyclopropylmothoxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof.