Patent ID: 7148349
Filing Date: 2006-12-12
Classification: A61P,C07F,C07H

Abstract:
1. A method of making a compound of Formula II.A or Formula II.B or salt thereof said method comprising: (a) isomerizing a mixture of trans/cis isomers of the compound of Formula I to give a ratio of trans/cis of about 85/15 or greater; wherein: V and L are trans relative to one another; V is selected from the group consisting of heteroaryl, and phenyl, all optionally substituted with 1–4 substituents; L is selected from the group consisting of halogen, and aryloxy optionally substituted with 1–2 substituents; and (b) reacting the compound of Formula I having the ratio of trans/cis isomers of about 85/15 or greater, or salt thereof, with MH, wherein: MH is selected from the group consisting of protected and unprotected oncolytic agents and antiviral agents and wherein: H is attached to O, S, or N of said oncolytic and antiviral agents; and M is attached to phosphorus via an oxygen, nitrogen or sulfur atom.