Patent ID: 6080771
Filing Date: 2000-06-27
Classification: C07D,C07H

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR81## wherein R.sup.1 represents: CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B independently represent hydrogen or lower alkyl; p1 represents an integer of 1 to 10; n2 represents an integer of 1 to 10; and R.sup.5 represents hydrogen, lower alkyl, --SiQ.sup.1 Q.sup.2 Q.sup.3 (wherein Q.sup.1, Q.sup.2, and Q.sup.3 independently represent lower alkyl or aryl), or CO(CR.sup.5A R.sup.5B).sub.m1 (O(CH.sub.2).sub.p2).sub.m2 OR.sup.5 C (wherein m1 represents an integer of 1 or 2; R.sup.5A and R.sup.5B independently represent hydrogen or lower alkyl; p2 represents an integer of 1 to 10; m2 represents an integer of 1 to 10; and R.sup.5C represents lower alkyl)}; or ##STR82## {wherein A.sup.1, A.sup.2, A.sup.3, and A.sup.4 independently represent hydrogen, hydroxy, lower alkanoyloxy, substituted or unsubstituted aralkyloxy, or --OSiA.sup.5 A.sup.6 A.sup.7 (wherein A.sup.5, A.sup.6, and A.sup.7 independently represent lower alkyl), or A.sup.3 and A.sup.4 may be combined with each other to represent a bond};R.sup.2 represents: hydrogen; or COR.sup.6 (wherein R.sup.6 represents lower alkyl, aralkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group, or --(CR.sup.6A R.sup.6B).sub.n3 (O(CH.sub.2).sub.p3).sub.n4 OR.sup.6C (wherein n3, p3, and n4 have the same meaning as n1, p1, and n2, respectively; and R.sup.6A, R.sup.6B, and R.sup.6C have the same meaning as R.sup.4A, R.sup.4B and R.sup.5, respectively)},R.sup.3 represents: lower alkyl; lower alkenyl; substituted or unsubstituted aralkyl; lower alkoxyalkyl; aralkyloxyalkyl; substituted or unsubstituted aryloxyalkyl; lower alkoxycarbonylalkyl; lower alkanoyloxyalkyl; alicyclic alkanoyloxyalkyl;--CH.sub.2 OCOR.sup.7 <wherein R.sup.7 represents --(CH.sub.2).sub.n5 R.sup.7A (wherein n5 represents an integer of 1 to 5; and R.sup.7A represents hydroxy, lower alkoxy, substituted or unsubstituted aralkyloxy, lower alkanoyloxy, --OPO(OH).sub.2, --OSO.sub.3 H, --OSiR.sup.7B.sub.3 (wherein R.sup.7B s are independently lower alkyl or aryl), lower alkanoyl, carboxy, lower alkoxycarbonyl, lower alkoxycarbonylamino, aralkyloxycarbonylamino, lower alkoxycarbonyloxy, lower dialkylaminocarbonyloxy, halogen, nitro, maleimido, 2-pyrrolidinon-1-yl, or --NHCOR.sup.7C (wherein R.sup.7C represents a substituted or unsubstituted lower alkyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, ##STR83## {wherein Q.sup.4 to Q.sup.7 independently represent hydrogen, hydroxy, lower alkanoyloxy, or --OSiQ.sup.8.sub.3 (wherein Q.sup.8 has the same meaning as R.sup.7B), or Q.sup.4 and Q.sup.5, or Q.sup.6 and Q.sup.7 are combined with each other to represent --OC(CH.sub.3).sub.2 O--}, or ##STR84## (wherein Q.sup.9 to Q.sup.12 have the same meaning as Q.sup.4 to Q.sup.7, respectively)>), --C(CH.sub.3).sub.2 R.sup.7D {wherein R.sup.7D represents lower alkoxycarbonylamino, aralkyloxycarbonylamino, or --NHCOR.sup.7E (wherein R.sup.7E has the same meaning as R.sup.7C)} --(CH.sub.2).sub.6n CHR.sup.7F R.sup.7G (wherein n6 represents an integer of 0 to 3; R.sup.7F represents lower alkanoyl, carboxy, lower alkoxycarbonyl, substituted or unsubstituted aryl, substituted or unsubstituted lower alkyl, or substituted or unsubstituted aralkyl; and R.sup.7G has the same meaning as R.sup.7D), substituted alicyclic alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or --CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n7 OR.sup.7H (wherein R.sup.7H represents hydrogen, lower alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl; and n7 represents an integer of 1 to 10)>; ##STR85## (wherein Q.sup.13 represents hydrogen, halogen, hydroxy, lower alkoxyalkyl, --OSiR.sup.7I.sub.3 (wherein R.sup.7I has the same meaning as R.sup.7B), --OCOQ.sup.14 {wherein Q.sup.14 represents hydrogen, alkyl, alicyclic alkyl, aralkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group, lower alkoxy, alicyclic alkoxy, 9-fluorenylmethoxy, aralkyloxy, substituted or unsubstituted aryloxy, alkylamino, (hydroxyalkyl)amino, --(CH.sub.2).sub.n8 Q.sup.14A (wherein n8 represents an integer of 1 to 3, and Q.sup.14A represents carboxy, or lower dialkylamino), CQ.sup.14B.sub.2 NQ.sup.14C COQ.sup.14D (wherein Q.sup.14B s are independently hydrogen or lower alkyl, Q.sup.14C represents hydrogen or lower alkyl, and Q.sup.14D represents lower alkyl, lower alkoxy, aralkoxy, aryl, aryloxy, or 9-fluorenylmethoxy), or --CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n9 OCH.sub.3 (wherein n9 represents an integer of 1 to 10)}, or ##STR86## {wherein Q.sup.15 represents hydrogen, hydroxy, --OSiR.sup.17.sub.3 (wherein R.sup.7J has the same meaning as R.sup.7B), or lower alkanoyloxy; and Q.sup.16 to Q.sup.18 independently represent hydroxy, --OSiR.sup.7J.sub.3, or lower alkanoyloxy, and Q.sup.17 and Q.sup.18 may be combined with each other to represent a bond}>; ##STR87## (wherein Q.sup.19 represents hydroxy, lower alkoxy, or a substituted or unsubstituted heterocyclic group; and Q.sup.20 represents hydrogen, lower alkyl, or aryl); ##STR88## (wherein Q.sup.21 represents alkyl); ##STR89## (wherein Q.sup.22 represents CH.sub.2, O, or N--CO.sub.2 Q.sup.23 (wherein Q.sup.23 represents lower alkyl)}; orphthalimidomethyl, or is combined with Y to represent a bond;Y is combined together with R.sup.3 to represent a bond or is combined together with Z to represent a bond;Z represents a hydrogen atom, or is combined together with Y to represent a bond; andW represents: oxygen; or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino),wherein the substituent on said substituted lower alkyl, substituted alicyclic alkyl, substituted aralkyl, substituted aralkyloxy, substituted aryl, substituted aryloxy, substituted aryloxyalkyl, substituted arylsulfonylamino and substituted heterocyclic group is 1 to 3 substituents independently selected from the group consisting of halogen, nitro, hydroxy, lower alkanoyl, lower alkanoyloxy, lower alkyl, lower alkoxy, aroyl, aroyloxy, lower alkoxycarbonyl, lower alkoxycarbonylamino, lower alkoxycarbonyloxy, lower dialkylcarbamoyloxy, lower alkoxyaralkyloxycarbonyl, --OPO (OH).sub.2, --OSO.sub.3 H, --OSiR.sup.7B.sub.3 and carboxy.