Patent ID: 9068232
Filing Date: 2015-06-30
Classification: C12Q,G16B

Abstract:
1. A method for distinguishing between oncocytoma, clear cell renal cell carcinoma (RCC), papillary (chromaphil) RCC and chromophobe RCC in a human subject with renal cancer, the method comprising: (a) obtaining a kidney tumor sample from the human subject; (b) determining an expression profile in said sample of SEQ ID NOS: 1-24 by contacting the sample with probes that hybridize to each of SEQ ID NOS: 1-24, wherein each probe comprises the complement of one of SEQ ID NOs: 1-24, and wherein the probes are attached to a solid substrate; (c) comparing said expression profile to a reference threshold value by using a classifier algorithm; and (d) determining whether the human subject has oncocytoma, clear cell renal cell carcinoma (RCC), papillary (chromaphil) RCC or chromophobe RCC based on altered expression of SEQ ID NOS: 1-24 in the sample relative to the reference threshold value; wherein increased expression of SEQ ID NOS: 3, 5, 7, 9, 11, 12, 16, 18, 19 and 23 relative to the reference threshold is indicative of the presence of oncocytoma; wherein increased expression of SEQ ID NOS: 1, 2, 4, 6, 8, 10, 13-15, 17, 20-22 and 24 is indicative of the presence of chromophobe RCC; wherein increased expression of SEQ ID NOS: 3, 5-7, 9, 12 and 24 is indicative of the presence of clear cell RCC; and wherein increased expression of SEQ ID NOS: 1, 2, 4, 8, 10, 11 and 13-23 is indicative of the presence of papillary RCC.