Patent ID: 9182412
Filing Date: 2015-11-10
Classification: A61P,C12Q,G01N,Y10T

Abstract:
1. A method of detecting an exposure of an individual to a Borrelia burgdorferi comprising: (a) providing a sample from the individual; (b) contacting the sample from the individual with a first protein and a second protein, wherein the first protein comprises a polypeptide BBK07 (SEQ ID NO:255) and the second protein comprises a polypeptide BBK12 (SEQ ID NO:256), wherein the first protein and the second protein have been characterized as immunogenic in mammals with a wherein said first protein is capable of specific binding to a first patient antibody, and said second protein is capable of specific binding to a second patient antibody, and (c) detecting the presence or absence of said first and/or second patient antibody in said sample based on detecting a specific binding, or non-specific binding or lack of binding thereof, of said first protein to said first antibody or said second protein to said second antibody, wherein the detecting of the specific binding of the first and second antibody to the first and second protein is accomplished by use of an antibody-based technique capable of detecting the specific binding of an antibody to a protein, and detecting the specific binding of the first protein to the first antibody or the second protein to the second antibody detects the presence of the first and/or the second antibody in the sample and indicates exposure of said individual to the