Patent ID: 7781423
Filing Date: 2010-08-24
Classification: A61K,A61P

Abstract:
1. A method for reducing deterioration of bone marrow function and for promoting regeneration of bone marrow comprising: administering a composition to a cancer patient treated with bone marrow damaging radiation treatment and/or bone marrow damaging chemotherapy, the composition comprising a heterocyclic compound, thereby normalizing blood cell and platelet counts, wherein the compound is represented by the formula: wherein R1 and R3-8 are independently hydrogen, C1-C26 straight, branched or cyclic alkanes or alkenes, aromatic hydrocarbons, alcohols, ethers, aldehydes, ketones, carboxylic acids, amines, amides, nitriles, or five- and/or six-membered heterocyclic moieties; wherein R9 and R10 considered together are ═O or ═CH-L-N wherein R9 and R10 considered independently are —OH or -L-N wherein R2 is represented by the formula: —X or —X′-L-N+(R11, R12, R13)Z -L-N wherein V is —S—, —Se—, —C—, —O— or —N; wherein Y is —S—, —Se—, —C—, —O— or —N; wherein -L-N wherein X is CH3 or Hydrogen; wherein —X′ is —CH2-, —OCH2-, —CH2O—, —SCH2- or —CH2S—; wherein L is a C1-C4 straight alkane, alkene, thiol, ether, or amine; wherein R11, R12 and R13 are independently C1-C4 straight alkanes, alkenes, thiols, amines, ethers or alcohols; and wherein Z