Patent ID: 8258125
Filing Date: 2012-09-04
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition comprising a therapeutically effective amounts of at least one HMG CoA reductase inhibitor present as a water soluble dihydroxy-open acid salt of a statin, the HMG CoA reductase inhibitor effective in lowering at least one of total cholesterol and/or LDL-C and at least one additional therapeutic agent exhibiting effects on at least one lipid abnormality presenting in a patient, wherein the at least one additional therapeutic agent raises HDL-C level in a patient wherein the water-soluble dihydroxy acid salt of a statin is a lactone prodrug having the general formula: wherein R is a chromophore and wherein the statin is selected from the group consisting of lovastatin, simvastatin, pravastatin, fluvastatin, artorvastatin, cerivastatin, pitavastatin, rosuvastatin and mixtures thereof; wherein the at least one additional therapeutic agent that raises HDL-C level in a patient is a water soluble fibrate derivative present in the free acid form, wherein the water soluble fibric acid derivative component is at least one of clofibrate, gemfibrozil, fenofibrate, bezafibrate, and ciprofibrate; and wherein the additional therapeutic agent further comprises is at least one of the following: a bile acid sequestrant, a nicotinic acid; or a bile acid sequestrant and a nicotinic acid.