Patent ID: 6214870
Filing Date: 2001-04-10
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula ##STR16##whereinX is >CR.sup.3 R.sup.4 or >C.dbd.O;Z is >CH.sub.2 or >NR.sup.1 ;R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl or a group of the formula ##STR17##n is an integer from one to six;R.sup.2 is hydrogen or (C.sub.1 -C.sub.6)alkyl;R.sup.3 is hydrogen or (C.sub.1 -C.sub.6)alkyl;R.sup.4 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, wherein each of said (C.sub.6 -C.sub.10)aryl or (C.sub.2 -C.sub.9)heteroaryl moieties is optionally substituted on any of the ring carbon atoms capable of forming an additional bond by one or more substituents per ring, independently selected from fluoro, chloro, bromo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, perfluoro(C.sub.1 -C.sub.3)alkyl, perfluoro(C.sub.1 -C.sub.3)alkoxy and (C.sub.6 -C.sub.10)aryloxy;Q is (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryl(C.sub.1 -C.sub.6)alkoxy(C.sub.2 -C.sub.9)heteroaryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.6 -C.sub.10)aryl, (C.sub.2 -C.sub.9)heteroaryloxy(C.sub.1 -C.sub.6)alkyl(C.sub.2 -C.sub.9)heteroaryl, (C.sub.6 -C.sub.10)aryl(C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, wherein each of said (C.sub.6 -C.sub.10)aryl or (C.sub.2 -C.sub.9)heteroaryl moieties is optionally substituted on any of the ring carbon atoms capable of forming an additional bond by one or more substituents per ring, independently selected from fluoro, chloro, bromo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, perfluoro(C.sub.1 -C.sub.3)alkyl, perfluoro(C.sub.1 -C.sub.3)alkoxy and (C.sub.6 -C.sub.10)aryloxy;with the proviso that when X is >C.dbd.O and Z is NR.sup.1 then R.sup.1 must be hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl or (C.sub.2 -C.sub.9)heteroaryl (C.sub.1 -C.sub.6)alkyl;or a pharmaceutically acceptable salt thereof.