Patent ID: 7348140
Filing Date: 2008-03-25
Classification: C12Q,G01N,Y10T

Abstract:
1. A method for selecting an appropriate course of treatment for a human who is being treated with or is a candidate for treatment with an agonist of the 1A/C adrenergic receptor, comprising: a) providing a sample comprising nucleic acids or proteins from a human who is being treated with or is a candidate for treatment with an agonist of the 1A/C adrenergic receptor; b) determining whether the sample from the human comprises a variant alpha 1A/C adrenergic receptor having serine residue at amino acid position 200; and c) selecting an appropriate course of treatment using an agonist of the 1A/C adrenergic receptor for said human based on whether said sample comprises said variant alpha 1A/C adrenergic receptor; wherein said agonist of the 1A/C adrenergic receptor is selected from the group consisting of phenylephrine, dobutamine, cirazoline and oxymetazoline; and wherein said determining step comprises directly determining the nucleotide present at position 1035 of the gene encoding the alpha 1A/C adrenergic receptor or directly determining the amino acid present at position 200 of the alpha 1A/C adrenergic receptor.