Patent ID: 6133258
Filing Date: 2000-10-17
Classification: A61K,A61P

Abstract:
A composition for inhibiting kainic acid-induced neurotoxicity, which comprises as an active ingredients a pyridothiazine derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier: ##STR83## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR84## R.sup.1 and R.sup.3 : one of them is not present and the other represents; R.sup.2 : a group represented by the formula ##STR85## the ring D: a 5- or 6-membered aromatic ring which may have one or two of one or more types of hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom;R.sup.6 and R.sup.7 : may be the same or different and each represent a hydrogen atom, a lower alkyl group which may have substituent(s), a lower alkanoyl group, a cycloalkyl group, an aryl group, a hydroxyl group, a lower alkoxy group, a halogeno-lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, a nitro group, a cyano group, an amino group, a mono- or di-lower alkylamino group, a hydroxylamino group or a lower alkoxyamino group, wherein R.sup.6 and R.sup.7 may form together with the ring D an 8- to 11-membered bicyclo ring which may have from one to four of one or more types of hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom and may have a lower alkyl group as a substituent);wherein R.sup.2 and R.sup.3 may together form a 5- to 7-membered nitrogen-containing heterocyclic group which is fused with a benzene ring which may have substituent(s), which may have a nitrogen atom as another hetero atom, and which may have substituent(s); andR.sup.4 and R.sup.5 : may be the same or different and each represent a hydrogen atom, a lower alkyl group or an aryl group; with the proviso that when one of R.sup.1 and R.sup.3 is a methyl group, then one of R.sup.6 and R.sup.7 represents a group other than a hydrogen atom.