Patent ID: 7579487
Filing Date: 2009-08-25
Classification: C07C,C07D

Abstract:
1. A process for making a compound of formula III or Formula IIIa: a pharmaceutically acceptable salt or mixture thereof, wherein: R R Z represents S(O) Y represents NHOH; and n is 0; said process comprising: (1) reacting a compound of formula IV:  wherein R  in the presence of an acid selected from the group consisting of methanesulfonic acid, pTsOH, CSA, PhSO (2) heating to a temperature of about 100° C. to about 125° C., for about one to about 30 hours, to produce a compound of formula VI: (3) asymmetrically hydrogenating a compound of formula VI in the presence of a metal catalyst and ligand to produce a compound of formula III or IIIa.