Patent ID: 8552177
Filing Date: 2013-10-08
Classification: C08J,C08L,D06M,Y10T

Abstract:
1. A method for making a porous functionalized crosslinked polysaccharide hydrogel coated structure comprising: a) impregnating a porous substrate selected from the group consisting of fibers, woven fabrics, nonwoven fabrics, membranes, mats, monolithic honeycomb structures, felt sheets, poly(HIPES) monolithic structures, three dimensional structures, sponges, and porous beads, with a room temperature stable aqueous polysaccharide solution forming a room temperature stable aqueous polysaccharide coating on the substrate, the aqueous solution containing, i) water, ii) a polysaccharide having a concentration in the aqueous solution from about 0.1% to about 20%, and selected from the group consisting of agarose, dextrans, cyclodextrins and blends thereof, iii) a gel-inhibiting agent having a concentration in the aqueous solution from about 18 to about 54%, and selected from the group consisting of ZnCl b) evaporating the water from the polysaccharide coating; c) exposing the dehydrated polysaccharide coating to a gelling agent selected from the group consisting of acetone and acetone in water to form a porous polysaccharide hydrogel coated substrate: d) exposing the hydrogel coated substrate to a crosslinking agent selected from the group consisting of epichlorohydrin, multifunctional epoxy compounds, multifunctional halide compounds, formaldehyde, gluteraldehyde, multifunctional aldehyde compounds, bis(2-hydroxy ethyl)sulfone, dimethyldichlorosilane, dimethylolurea, dimethylol ethylene urea, diisocyanate compounds, and polyisocyanate compounds to form a porous crosslinked polysaccharide hydrogel coated substrate; and e) contacting the crosslinked polysaccharide hydrogel coated substrate with sodium 3-bromopropanesulfonate, and attaching sulfopropyl functional groups by a functionalization reaction to the crosslinked polysaccharide hydrogel coated substrate.