Patent ID: 6020518
Filing Date: 2000-02-01
Classification: C07C,C07D,Y02P

Abstract:
A process for producing a .beta.-amino-.alpha.-hydroxy acid derivative of the general formula (2): ##STR17## (wherein R.sup.1 represents a substituted or unsubstituted alkyl group containing 1 to 20 carbon atoms, a substituted or unsubstituted aralkyl group containing 7 to 30 carbon atoms, or a substituted or unsubstituted aryl group containing 6 to 30 carbon atoms; Q.sup.1 and Q.sup.2 each independently represents a hydrogen atom or an amino-protecting group or Q.sup.1 and Q.sup.2 combinedly represent a phthaloyl group) which comprises hydrolyzing an .alpha.-amino-.alpha.', .alpha.'-dihaloketone derivative of the general formula (1): ##STR18## (wherein R.sup.1 is as defined above; X.sup.1 and X.sup.2 each independently represents a halogen atom; P.sup.1 and P.sup.2 each independently represents a hydrogen atom or an amino-protecting group or P.sup.1 and P.sup.2 combinedly represent a phthaloyl group) in the presence of a base, followed by protecting the amino group or without protecting the same.