Patent ID: 6566364
Filing Date: 2003-05-20
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): wherein:V represents a single bond or a linear or branched (C1-C6)alkylene chain, M represents a single bond or a linear or branched (C1-C6)alkylene chain, A and E each represents nitrogen or CH, but at least one of the two groups A or E represents nitrogen, W represents a group of formula (ii), and also may represent a group of formula (iii) but only when V represents a single bond and A represents nitrogen, in which groups of formulae (ii) and (iii): X represents carbonyl, sulphonyl or sulphoxide, G2 represents a single bond or methylene, G3 represents: â€”CH2â€”CH2â€” or â€”CH&boxH;CHâ€” when G2 represents a bond, or methylene when G2 represents methylene, T represents phenyl fused with the ring to which it is attached, R1 represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, R2a and R2b, which are the same or different, each independently of the other represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, mercapto, linear or branched (C1-C6)alkylthio, linear or branched (C1-C6)trihaloalkyl, cyano, nitro, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety may be linear or branched, linear or branched (C1-C6)trihaloalkoxy, aryloxy, aryl-(C1-C6)alkoxy in which the alkoxy moiety is linear or branched, linear or branched (C1-C6)alkylsulphonate, linear or branched (C1-C6)trihaloalkylsulphonate and linear or branched (C1-C6)alkylsulphonyl, or R2a+R2b, taken together in adjacent positions, represent a group selected from methylenedioxy, 1,2-ethylenedioxy, 1,3-propylenedioxy, and ethylene optionally substituted by a group selected from cyano, hydroxymethyl, linear or branched (C1-C6)alkoxycarbonyl, aryloxycarbonyl and aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched, Y represents aryloxy, heteroaryl-A-oxy or heteroaryl-B, each of which groups may optionally be substituted by one or more groups, which may be the same or different, selected from among the definitions of R2a, its isomers, its hydrates, its solvates and addition salts thereof with a pharmaceutically acceptable acid,wherein:aryl is understood to mean a group selected from phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl, indenyl and benzocyclobutyl, heteroaryl-A is understood to mean a monocyclic aromatic or bicyclic, 5- to 12-membered system containing one or two hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur, and wherein, in the case of a bicyclic system, one of the rings has an aromatic character and the other ring may be aromatic or partially hydrogenated, heteroaryl-B is understood to mean a monocyclic aromatic or bicyclic aromatic, 5- to 12-membered system containing from 1 to 3 hetero atoms, which may be the same or different, selected from oxygen, nitrogen and sulphur, aryloxy is understood to mean aryl as defined hereinbefore attached to oxygen, heteroaryl-A-oxy is understood to mean heteroaryl-A as defined hereinbefore attached to an oxygen atom.