Patent ID: 6376516
Filing Date: 2002-04-23
Classification: C07D

Abstract:
A method for the treatment of neoplastic diseases, comprising administering to a mammal in need of such treatment an effective amount of a composition comprising a compound of the formula wherein: A is(i) â€ƒand W is C1-6 alkyl; or (ii) â€ƒand forms a six membered ring with B, said ring containing one nitrogen; Y is (a) C1-6 alkyl, or H; (b) C(O)â€”C1-6 alkyl; (c) â€ƒwherein Z is C1-6 alkyl or Oâ€”C1-6 alkyl; (d) aryl; or (e) heterocycle; B is a single bond, OH or halo; C is â€”OH, â€”CH2â€” or forms a 5-membered lactone or lactam ring with D; and D is: (i) â€”OH, â€”CH2â€”halo, â€”CH(O)â€”, â€”COOH, â€”C(O)â€”Oâ€”C1-6 alkyl, â€”(CH2)nâ€”, â€”CHOHâ€”, wherein n is an integer and is 1,2, or 3; or (ii) forms a 5-membered lactone or lactam ring with C; E is â€”H or â€”CH3; and F is â€”OH or â€”OCH3, or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier, said composition useful in the treatment of neoplastic diseases, with the proviso that the formula excludes noscapine of the structure.