Patent ID: 6420376
Filing Date: 2002-07-16
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 is selected from the group consisting of: â€ƒor their regioisomers where not specified; R2 and R3 are independently selected from the group consisting of: hydrogen, â€”C1-C6 alkyl, â€”C3-C7 cycloalkyl, and â€”CH2-phenyl, wherein the alkyl, the cycloalkyl and the phenyl are unsubstituted or substituted with â€”OR2a, â€”C(O)OR2a, â€”C(O)N(R2a)(R2b), halogen, â€”C1-C4 alkyl, â€”S(O)nR2a, â€”NHS(O)2(R2a), and wherein R2 and R2 are optionally joined to form a C4-C5 cyclic ring being selected from the group consisting of pyrrolidine, piperidine, piperazine, morpholine, and thiomorpholine; R2a and R2b are independently selected from: hydrogen and C1-C6 alkyl; R3a and R3b are independently selected from: hydrogen, â€”C1-C6 alkyl, â€”OR2, and halogen; R4 is selected from: hydrogen, C1-C6 alkyl, and substituted C1-C6 alkyl where the substituents on alkyl are selected from halo, â€”OR2, phenyl, C1-6 alkoxycarbonyl, â€”S(O)nR2a, and â€”NHS(O)n(R2a); R5 is selected from: hydrogen, C1-C6 alkyl, substituted C1-C6 alkyl where the substituents on alkyl are selected from halo, â€”OR2, phenyl, â€”S(O)nR2a, â€”NHS(O)n(R2a), R5a and R5b are independently selected from: hydrogen, C1-6 alkyl, or substituted C1-C6 alkyl where the substituents are selected from: halo, â€”OR2, C1-C6 alkoxy, phenyl, C1-C6 alkoxycarbonyl, â€”S(O)nR2a, â€”NHS(O)n(R2a); R6a and R6b are independently selected from: hydrogen, C1-C6 alkyl, or trifluoromethyl; X is selected from â€”CH2â€”, â€”Oâ€” and â€”Sâ€”; n is independently 0, 1 or 2; and pharmaceutically acceptable salts and individual diastereomers thereof.