Patent ID: 7081239
Filing Date: 2006-07-25
Classification: A23L,A23V,A61B,A61K,A61P,G01N,Y10S,Y10T

Abstract:
1. A method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal having an intrinsic cholinergic afferent neural pathway projecting from a peptide YY-sensitive primary sensory neuron in the intestinal wall to a prevertebral celiac ganglion and having an adrenergic efferent neural pathway projecting from said ganglion to one or more enterochromaffin cells in the intestinal mucosa and/or to a serotonergic interneuron linked in a myenteric plexus and/or submucous plexus to an opioid interneuron, said opioid intemeuron also being linked by an intestino-fugal opioid pathway projecting to said ganglion, with one or more neural connections to the central nervous system and back to the gut projecting from the ganglion, said method comprising: providing a pharmaceutically acceptable composition, comprising an active agent selected from the group consisting of administering the pharmaceutically acceptable composition to the mammal, said active agent being delivered in an amount and under conditions such that the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic intemeuron and/or the opioid interneuron are activated by the action of (A), whereby the rate of upper gastrointestinal transit is slowed, or such that activation of the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic intemeuron and/or the opioid intemeuron is blocked by the action of (B), whereby the rate of upper gastrointestinal transit is accelerated.