Patent ID: 6498167
Filing Date: 2002-12-24
Classification: C07D

Abstract:
A compound having the formula:B whereinB is P and Q are â€ƒprovided that when P is â€ƒand vice versa; T, W, and X are each, independently, carbon or nitrogen, provided that when T is carbon, it may be optionally substituted with R1; and provided that no more than 2 of T, W, and X are nitrogen; â€ƒis a phenyl ring or is a heteroaryl ring of ring 5-6 atoms which may contain 0-2 heteratoms selected from nitrogen, oxygen, and sulfur, in addition to any heteroatoms defined by W or X; wherein the phenyl or heteroaryl ring may be optionally mono-, di-, or tri-substituted with R1; Z is a phenyl, naphthyl, heteroaryl, or heteroaryl fused to phenyl, wherein the heteroaryl moiety contains of 5-6 ring atoms and 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur; wherein the phenyl, naphthyl, heteroaryl, or phenyl fused heteroaryl moieties may be optionally mono-, di-, or tri-substituted with R1; R1 is hydrogen, halogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cyclocalkyl of 3-6 carbon atoms, â€”(CH2)nZ, â€”OR2, â€”CN, â€”COR2, perfluoroalkyl of 1-4 carbon atoms, â€”CONR2R3, â€”S(O)XR2 â€”OPO(OR2)OR3, â€”PO(OR2)R3, â€”OC(O)NR2R3, â€”COOR2, â€”CONR2R3, â€”SO3H, â€”NR2R3, â€”NR2COR3, â€”NR2COOR3, â€”SO2NR2R3, â€”NO2, â€”N(R2)SO2R3, â€”NR2ONR2R3, â€”NR2C(&boxH;NR3)NR2R3, â€”SO2NHCOR4, â€”CONHSO2R4, -tetrazol-5-yl, â€”SO2NHCN, â€”SO2NHCONR2R3, or Z; V is a saturated or partially unsaturated heterocycloalkyl ring of 5-7 ring atoms having 1-3 heteroatoms selected from N, O, or S, which may be optionally mono-, or di-substituted with R2; R2 and R3 are each, independently, hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R4 is alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R5 is hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, Z, or V; n=1-6; X=0-2 or a pharmaceutically acceptable salt thereof.