Patent ID: 6333346
Filing Date: 2001-12-25
Classification: A61P,C07D

Abstract:
A method of treating a tumor in a patient in need thereof, comprising administering to said patient an anti-tumor effective amount of a compound of the general formula (I): ##STR8##wherein:A is oxygen or sulfur;X is oxygen or sulfur;R1 and R2 are independently hydrogen or an alkyl group with from 1 to 6 carbon atoms;R is selected from: (C.sub.1 -C10)alkyl, (C3-C.sub.7)cycloalkyl, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylsulphinyl, (C.sub.1 -C.sub.4)alkylsulphonyl, (C.sub.1 -C.sub.4)hydroxyalkyl, naphthyl, phenyl, phenyl substituted by from 1 to 3 groups selected from: (C.sub.1 -C.sub.4)alkyl; chlorine, bromine, iodine or fluorine; (C.sub.1 -C.sub.4)perfluoroalkyl; hydroxy; (C.sub.1 -C.sub.4)alkoxy; amino; mono- or di-(C.sub.1 -C.sub.4)alkylamino; aminosulphonyl;(C.sub.1 -C.sub.4)alkylsulphonamido; phenyl- or tolyl-sulphonamido; carboxy; (C.sub.1 -C.sub.4)alkoxycarbonyl; amidocarbonyl or (C.sub.1 -C.sub.4)alkylamidocarbonyl; carboxaldehyde; (C.sub.1 -C.sub.4)alkylcarbonyl; nitro; phenylthio; cyanomethyl, and optionally substituted phenyloxy or optionally substituted phenyl--(C.sub.1 -C.sub.4)--alkyl or R is a 5- or 6-membered aromatic or non-aromatic heterocycle containing from 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which can be optionally benzocondensed,the pure stereoisomers or mixtures thereof as well as salts thereof with pharmaceutically acceptable acids or bases, with the proviso, that when, A is oxygen and X is oxygen, R is not C.sub.1 -C.sub.10)alkyl.