Patent ID: 6306860
Filing Date: 2001-10-23
Classification: C07D

Abstract:
A 2,5-pyridinedicarboxylic acid derivative, and pharmaceutically acceptable salts thereof, of the formula 1 ##STR98##whereinR.sub.1 is selected from the group consisting of:a hydroxy group,a straight or branched alkyl group of 1 to 6 carbon atoms,a cycloalkyl group of 3 to 6 carbon atoms unsubstituted or substituted with an alkyl group of 1 to 3 carbon atoms,an alkyl group of 1 to 3 carbon atoms substituted with a cycloalkyl group of 3 to 6 carbon atoms,a straight or branched hydroxyalkyl group of 1 to 6 carbon atoms,a straight or branched dihydroxyalkyl group of 3 to 6 carbon atoms,a straight or branched alkoxy group of 1 to 4 carbon atoms,a hydroxyalkoxy group of 2 to 4 carbon atoms,a straight or branched alkoxyalkyl group of 2 to 6 carbon atoms,a dialkoxyalkyl group of 3 to 6 carbon atoms,a dialkylamino group of 2 to 4 carbon atoms,an acetylamino group,a vinyl group, anda saturated or unsaturated five or six membered heterocyclic ring having 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, said heterocyclic ring being unsubstituted or substituted with same or different substituents selected from the group consisting of an alkyl group of 1 to 3 carbon atoms, an alkoxy group of 1 to 3 carbon atoms, a hydroxyalkyl group of 1 to 3 carbon atoms, a phenyl group, a carbamoyl group and a hydroxy group;R.sub.2 is selected form the group consisting of:a hydrogen atom,a phenyl group,a straight or branched alkyl group of 1 to 4 carbon atoms,a straight or branched hydroxyalkyl group of 2 to 4 carbon atoms, andan alkoxyalkyl group of 2 to 4 carbon atoms;R.sub.3 is selected form the group consisting of:a 2-hydroxyethyl group, anda 3-amino-2-pyridyl group having the formula ##STR99##in which Q is a hydrogen atom or a straight or branched alkyl group of 1 to 4 carbon atoms; andn is 0 to 4.