Patent ID: 6268367
Filing Date: 2001-07-31
Classification: A61K,A61P

Abstract:
A method to enhance bone formation in a vertebrate animal which method comprises administering to a vertebrate subject in need of such treatment an amount of a compound of formula I: ##STR10##whereinA and B are each members independently selected from the group consisting of aryl, substituted aryl, carbocyclic ring, substituted carbocyclic ring, heterocyclic ring, substituted heterocyclic ring, and combinations thereof, said combinations being fused or covalently linked and said substituents being selected from the group consisting of halogen, haloalkyl, hydroxy, aryloxy, benzyloxy, alkoxy, haloalkoxy, amino, monoalkylamino, dialkylamino, acyloxy, acyl, unsubstituted alkyl and aryl;R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen and alkyl groups having from 1 to 6 carbon atoms, or taken together form a ring selected from the group consisting of saturated or unsaturated five-member rings, saturated or unsaturated six-member rings and saturated or unsaturated seven-member rings;Y.sup.1 and Y.sup.2 are each independently a bond or a divalent radical selected from the group consisting of --CH.sub.2 --, --NHC(O)--, --NRC(O)--, --NHC(S)--, --NRC(S)--, --NHC(.dbd.NH)--, --OC(O)--, --C(O)--, and --C(S)--, in which R is a lower alkyl group of from one to six carbon atoms; andn is an integer of from zero to four.