Patent ID: 6693099
Filing Date: 2004-02-17
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having a formula: or an optical isomer, diastereomer, enantiomer, or pharmaceutically-acceptable salt thereof, wherein:(a) A is A1; (b) A1 is a group having a formula: wherein:(i) each R1 is independently selected from the group consisting of a hydrogen atom, a hydroxyl group, a hydrocarbon group, a substituted hydrocarbon group, a heterogeneous group, a substituted heterogeneous group, a carbocyclic group, a substituted carbocyclic group, a heterocyclic group, a substituted heterocyclic group, an aromatic group, a substituted aromatic group, a heteroaromatic group, and a substituted heteroaromatic group; (ii) x is 1 to 10; (iii) R2 is selected from the group consisting of a substituted hydrocarbon group and a substituted heterogeneous group; (iv) D1 and D2 are each independently selected from the group consisting of â€”C(O)â€” and â€”NR3â€”, wherein R3 is selected from the group consisting of a hydrogen atom, a hydrocarbon group, a substituted hydrocarbon group, a heterogeneous group, a substituted heterogeneous group, a carbocyclic group, a substituted carbocyclic group, a heterocyclic group, a substituted heterocycle group, an aromatic group, a substituted aromatic group, a heteroaromatic group, and a substituted heteroaromatic group; wherein, optionally, R2 and R3 may be bonded together to form a ring selected from the group consisting of a heterocyclic group and a substituted heterocyclic group; (v) y is 0 or 1 and z is 0 or 1; with the provisos that when y is 0, z is 1 and when y is 1, z is 0, when y is 0 and D1 is â€”NR3â€”, then D2 is â€”C(O)â€”, when y is 0 and D2 is â€”NR3â€”, then D1 is â€”C(O)â€”; and(c) A2 is a group having a formula: wherein:(i) each R1 is independently selected from the group consisting of a hydrogen atom, a hydroxyl group, a hydrocarbon group, a substituted hydrocarbon group, a heterogeneous group, a substituted heterogeneous group, a carbocyclic group, a substituted carbocyclic group, a heterocyclic group, a substituted heterocyclic group, an aromatic group, a substituted aromatic group, a heteroaromatic group, and a substituted heteroaromatic group; (ii) u is 0 to 10; (iii) p is 0 to about 10; (iv) v is 0 or 1; (v) D3 is selected from the group consisting of â€”S(O)2â€”, â€”C(O)â€”, and CR1(OH)â€”, with the provisos that when D3 is â€”S(O)2â€”, then D1 is â€”C(O)â€”, D2 is â€”NR3â€”, and R2 and R3 are bonded together to form the ring structure, and when D3 is â€”C(O)â€”, v is 0, and R5 contains a â€”C(O)â€” group, then p is not 0; and (vi) R5 is selected from the group consisting of a hydrocarbon group, a substituted hydrocarbon group, a heterogeneous group, a substituted heterogeneous group, a carbocyclic group, a substituted carbocyclic group, a heterocyclic group, a substituted heterocyclic group, an aromatic group, a substituted aromatic group, a heteroaromatic group, and a substituted heteroaromatic group; wherein when A is A1 then R1 is a heteroaromatic group.