Patent ID: 6951657
Filing Date: 2005-10-04
Classification: A61K,A61P

Abstract:
1. Coated particles based on granulated microcrystals of ibuprofen, its isomers and its pharmaceutically acceptable salts, wherein they have a coating consisting of a mixture consisting of: A) from 5 to 50% by weight, of ethyl cellulose, based on the ibuprofen, B) from 10 to 60% by weight, of hydroxypropyl methyl cellulose, based on the ethyl cellulose, C) from 0.1 to 40% by weight, of silica with antistatic and permeabilizing properties, based on the ethyl cellulose, and D) from 0 to 50% by weight of an agent favoring the solubilization of the ibuprofen, based on the ibuprofen, said agent being selected from the group comprising mannitol, starch, pharmaceutically acceptable self-emulsifying bases, polyvinylpyrrolidones, stearic macrogol glycerides, alkali metal salts of organic origin, surfactants and mixtures thereof, whereby said coating—of which at least one of the constituents can be used for the granulation of the ibuprofen microcrystals to produce said particles—allows the masking of the unpleasant taste of the ibuprofen, the significantly reduction of its irritant effect on the throat after swallowing, and the release of 80% of the ibuprofen in 30 minutes in 900 ml of a buffer solution of pH 7.2, using a type 4 apparatus described in USP XXIII p. 1794.