Patent ID: 6509014
Filing Date: 2003-01-21
Classification: A61K,A61P,Y10S

Abstract:
A topical cosmetic composition that comprises, in an amount effective to treat skin redness, rosacea or discreet erythema upon topical application:(i) at least one calcitonin gene related peptide (CGRP) antagonist, said CGRP antagonist exhibiting a coherent pharmacological response in at least one of the following tests: (a) the antagonist reduces vasodilation induced by capsaicin, (b) the antagonist induces an inhibition of the release of CGRP by sensitive nerve fibers, (c) the antagonist reduces inhibition of the contraction of vas deferens smooth muscle induced by CGRP; and (ii) at least one antagonist of a neuropeptide other than CGRP, said antagonist being a substance P antagonist, and/or at least one inflammation mediator antagonist; which are comprised in a cosmetically acceptable topical carrier; wherein the amount of said CGRP antagonist ranges from 0.000001% to 10% by weight relative to the total weight of the composition.