Patent ID: 8663606
Filing Date: 2014-03-04
Classification: A61K,A61P,B82Y,C07D

Abstract:
1. A method for producing a cationic liposomal preparation comprising: (a) mixing an organic solvent with a lipophilic active compound and a cationic lipid to form an organic solution; (b) mixing the organic solution of step (a) with an aqueous solution comprising a stabilizing agent to form a dispersion of cationic liposomes, wherein the dispersion comprises cationic liposomes in an aqueous medium; (c) optionally homogenising the dispersion of step (b) at least once; (d) optionally sterile filtrating the dispersion obtained in step (c); and (e) optionally dehydrating the dispersion of cationic liposomes of step (d) to form a cationic liposomal preparation; wherein the cationic liposomes in the dispersion of step (b) comprise at least one cationic lipid in an amount of at least about 30 mol % and a lipophilic active compound in an amount of at least about 0.1 mol %; and wherein the stabilizing agent in the dispersion of step (b) is present in an amount of about 0.1% (m/v) to about 20% (m/v); and, wherein the pH value of the aqueous medium in any one of steps (b), (c), or (d) is between about 3.0 and 7.0.