Patent ID: 9050392
Filing Date: 2015-06-09
Classification: A61K,A61L,A61P,C08B,C08J,C08L

Abstract:
1. A method for preparing an injectable crosslinked sterile homogenous hydrogel, wherein it comprises the following successive steps: (a) preparing an aqueous solution comprising a water-soluble polymer derived from cellulose and at least one second water-soluble polymer, wherein the total polymer concentration by weight is between 1% and 4% of the total weight; (b) adding bone substitute comprising solid particles; (c) pouring the resulting liquid mixture containing the solid particles, in a container, and closing said container by means of a system impervious to water and to gas; and (d) exposing the container containing the liquid and the optional solid particles to a dose of β or γ radiations comprised between 5 and 50 kGy, thus producing an injectable crosslinked sterile homogenous hydrogel; wherein the cellulose-derived polymersecond water-soluble polymer weight ratio is between 65/35 and 85/15.