Patent ID: 8617546
Filing Date: 2013-12-31
Classification: A61K,A61P,C07K

Abstract:
1. An anticancer agent, comprising a first anticancer factor selected from a group consisting of alpha-galactosyl ceramide, alpha glucuronosyl ceramide, phosphatidylinositoltetramannoside, isoglobotrihexosylceramide, ganglioside GD3, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, sulfatide, beta-galactosylceramide, lipophophoglycan, glycoinositol phospholipid, alphagalactosylceramide analogs including beta-anomer galactoceramide and alpha-anomer galactosylceramide, and combinations thereof, and a second anticancer factor selected from the group consisting of anti-PD-1 antibody and anti-PD-L1 antibody, having a function of reversing unresponsiveness of iNKT cells in which anergy is induced by administration with an iNKT cell ligand.