Patent ID: 6265431
Filing Date: 2001-07-24
Classification: A61P,C07D

Abstract:
A cycloalkyl-indole and -azaindole derivative of the formula (I) ##STR347##in whichR.sup.1 and R.sup.2, including the double bond connecting them, together form a phenyl ring,R.sup.3 and R.sup.4, including the double bond connecting them, together form a phenyl ring or a 4-to 8-membered cycloalkenethe ring systems mentioned under R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 optionally being substituted up to 3 times by identical or different halogen, trifluoromethyl, carboxyl or hydroxyl substituents, by straight-chain or branched alkoxy or alkoxycarbonyl each having up to 6 carbon atoms or by straight-chain or branched alkyl having up to 6 carbon atoms, which, for its part, can be substituted by hydroxyl or by straight-chain or branched alkoxy having up to 4 carbon atoms,D represents hydrogen, cycloalkyl having 4 to 12 carbon atoms or straight-chain or branched alkyl having up to 12 carbon atoms,E represents the --CO-- or --CS-- group,L represents group of the formula --NR.sup.9,whereinR.sup.9 denotes hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or phenyl,R.sup.5 represents phenyl which is optionally substituted 1-3 times by identical or different substituents selected from the group consisting of nitro, carboxyl, halogen, cyano, straight or branched C.sub.2 -C.sub.6 alkenyl, straight or branched C.sub.1 -C.sub.6 alkoxycarbonyl, substituted or unsubstituted C.sub.1 -C.sub.6 straight or branched alkyl wherein the substituents on the alkyl are hydroxy, carboxyl, straight or branched C.sub.1 -C.sub.6 alkoxycarbonyl,or the said phenyl is further optionally substituted by a group of the formula --OR or --NR.sup.11 R.sup.12,whereinR.sup.10 denotes hydrogen or straight-chain or branched alkyl and alkenyl each having up to 6 carbon atoms,R.sup.11 and R.sup.12 are identical or different and denote phenyl, hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms or straight-chain or branched acyl having up to 8 carbon atoms, which is optionally substituted by a group of the formula --NR.sup.13 R.sup.14,whereinR.sup.13 and R.sup.14 are identical or different and denote hydrogen or straight chain or branched acyl having up to 8 carbon atoms,R.sup.6 represents hydrogen, carboxyl or straight-chain or branched alkoxycarbonyl having up to 5 carbon atoms,or represents straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or by a group of the formula --O--CO--R.sup.15,whereinR.sup.15 denotes phenyl which is optionally substituted up to 3 times by identical or different halogen or hydroxyl substituents or by straight-chain or branched alkyl having up to 5 carbon atoms,or straight-chain or branched alkyl or alkenyl each having up to 22 carbon atoms, each of which is optionally substituted by a group of the formula --OR.sup.16,whereinR.sup.16 is hydrogen, benzyl, triphenylmethyl or straight-chain or branched acyl having up to 6 carbon atoms,R.sup.7 represents hydrogen,if appropriate in an isomeric form, or a physiologically acceptable salt thereof.