Patent ID: 6911453
Filing Date: 2005-06-28
Classification: C07D

Abstract:
1. A compound of the formula I wherein: R1, R2, R3 and R4 are independently of one another H, F, Cl, Br, I, CN, NO 2 , OH, NH 2 , C a H 2a+1 , C qq H 2qq−1 , OC b H 2b+1 , COOR10, OCOR10, COR10 or O x —(CH 2 ) y -phenyl; wherein a and b are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8, wherein the groups C qq is 3, 4, 5, 6, 7 or 8, wherein the group CqqH2qq−1 is unsubstituted or substituted where one or more H atoms are replaced by F atoms; R10 is H or C x is zero or 1; y is zero, 1, 2, 3 or 4; where the phenyl ring in the group O or R1, R2, R3 and R4 are independently of one another chosen from a heteroaryl with at least one heteroatom chosen from 1, 2, 3 or 4 N atoms, 1 oxygen atom and 1 S atom, present as ring atoms; or R1, R2, R3 and R4 are independently of one another CONR11R12 or NR11R12; wherein R11 and R12 are independently of one another H, C or R11 and R12 together with the N atom to which they are bonded form a 5-, 6- or 7-membered ring; or R11 and R12 are independently of one another COR14, CSR14 or SO or R1, R2, R3 and R4 are independently of one another —O h —SO j -R15, with h is zero or 1; j is zero, 1 or 2; R15 is C  but where R2 does not equal H in any of the foregoing definitions, R5 is H, C p H 2p+1 , C ss H 2ss−1 , COR20 or SO 2 R20; wherein p is 1, 2, 3, 4, 5, 6, 7 or 8, ss is 3, 4, 5, 6, 7 or 8, R20 is C R6 is H, F, Cl, Br, I, C s H 2s+1 , C dd H 2dd−1 , OH, OC t H 2t+1 or OCOR22; wherein s and t are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8; dd is 3, 4, 5, 6, 7 or 8, wherein the groups C R22 is C R7, R8 and R9 are independently of one another —O v —SO w —R 23 ; wherein v is zero or 1; w is zero, 1 or 2; R23 is C or R7, R8 and R9 are independently of one another NR32COR30, NR32CSR30 or NR32SO bb R30; R30 is H, C R32 and R33 are independently of one another H or C bb is 2 or 3; cc is 1, 2, 3, 4, 5, 6, 7 or 8; yy is 3,4,5,6, 7 or 8; h is 1, 2, 3, 4, 5, 6, 7 or 8, or R31 together with a CH R30 is a 5- or 6-membered heteroaryl with at least one hetero atom chosen from 1, 2, 3 or 4 N atoms, zero, 1 S atom and 1 O atom, which is unsubstituted or substituted by up to three substituents chosen from F, Cl, Br, I, C or R7, R8 and R9 are independently of one another H, F, Cl, Br, I, NO 2 , CN, OH, NH 2 , C ee H 2ee+1 , C ww H 2ww−1 , OC ff H 2ff+1 , NR40R41, CONR40R41, COOR42, COR42 or OCOR42, ee and ff are independently of one another 1, 2, 3, 4, 5, 6, 7 or 8; ww is 3, 4, 5, 6, 7 or 8, wherein the groups C R40 and R41 are independently of one another H, C or R40 and R41 with the N atom to which they are bonded form a 5- or 6-membered ring; R42 is H or C  with the proviso that two substituents chosen from the group R7, R8 and R9 can not simultaneously be OH and OCH 3 , and that at least one of the substituents R7, R8 and R9 is chosen from CONR40R41, —O v —SO w -R23, NR32COR30, NR32CSR30 and NR32SO bb R30; or a pharmaceutically acceptable salt thereof, or a trifluoroacetate thereof in any stereoisomeric form, or a mixture of any such compounds in any ratio.