Patent ID: 6875869
Filing Date: 2005-04-05
Classification: C07D

Abstract:
1. A process for the preparation of the compounds of general formula (I) wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R wherein R R R′ is selected from methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, and OCH wherein R″ is selected from hydrogen,fluoro and chloro, with the proviso that R″ is selected from flouro and chloro only when R′ is selected from flouro and chloro; by reacting a quinoline-3-carboxylic acid ester derivative of formula A with an aniline derivative of formula B according to the following reaction diagram, to give the compound of general formula (I), designated “C”, and methanol, designated “D”: in a solvent selected from straight or branched alkanes and cycloalkanes or mixtures thereof with a boiling point between 80 and 200° C.