Patent ID: 6727255
Filing Date: 2004-04-27
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula wherein:R1 is selected from the group consisting of 1-(4-phenyl)piperazinyl, 1-(4-cyclohexyl)piperazinyl, 1-(4-phenyl)piperidinyl, 1-(4-cyclohexyl)piperidinyl, and 1-(4-isopropyl)piperazinyl; R2 is â€”COâ€”R6; R6 is hydrogen, C1-C4 alkyl, C1-C3 haloalkyl, phenyl, C1-C3 alkoxy, C1-C3 hydroxyalkyl, amino, C1-C4 alkylamino, di(C1-C4 alkyl)amino, or â€”(CH2)qâ€”R7; q is 0 to 3; R7 is phenoxy, phenylthio, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, benxofuranyl, quinolinyl, isoquinolinyl, phenyl-(C1-C4 alkyl)-, quinolinyl-(C1-C4 alkyl)-, isoquinolinyl-(C1-C4 alkyl)-, benzoyl-C1-C3 alkyl; any one of which R7 groups may be substituted with halo, trifluoromethyl, C1-C4 alkoxy, amino, C1-C4 alkylamino, di(C1-C4 alkyl)amino, C2-C4 alkanoylamino, phenyl, piperazinyl, C3-C8 cycloalkyl, benzyl, piperidinyl, pyridinyl, pyrimidinyl, pyrrolidinyl, C2-C6 alkanoyl, C1-C4 alkyl, or C1-C4 alkoxycarbonyl; any of which phenyl, piperazinyl, C3-C8 cycloalkyl, benzyl, piperidinyl, pyridinyl, pyrimidinyl, pyrrolidinyl, C2-C6 alkanoyl, C1-C4 alkyl, or C1-C4 alkoxycarbonyl groups may be substituted with halo, trifluoromethyl, C1-C4 alkoxy, C1-C4 alkyl, C1-C4 alkylamino, di(C1-C4 alkyl)amino, or C2-C4 alkanoylamino; Ra is methoxy, ethoxy, chloro, trifluoromethyl or methylthio; and Rb is hydrogen or C1-C4 alkyl; or pharmaceutically acceptable salt or solvate thereof.