Patent ID: 6388091
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A method of preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one of formula (I) or a pharmaceutically acceptable salt thereof which comprises reacting 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one of formula (II) with a 2-methylimidazole derivative of formula (III) in an organic solvent or in a mixture of an organic solvent and water, in the presence of a halosilane compound: wherein R1 is N,N-dimethylamino, N,N-diethylamino, N,N-dipropylamino, morpholin-4-yl, piperidin-1-yl or pirrolidin-1-yl.