Patent ID: 7666446
Filing Date: 2010-02-23
Classification: A61K,A61P

Abstract:
1. A composition for oral delivery of a pharmaceutical agent that is poorly absorbed through the intestinal mucosa, the composition comprising a mixture of an effective amount of the pharmaceutical agent; an enhancer for increasing absorption of the pharmaceutical agent through the intestinal mucosa; a promoter that functions synergistically with the enhancer for further increasing absorption of the pharmaceutical agent through the intestinal mucosa; and a protector for inhibiting decomposition or inactivation of the pharmaceutical agent; wherein the enhancer is a fatty acid ester selected from the group consisting of sucrose stearate, sucrose palmitate, sucrose laurate, sucrose behenate, sucrose oleate, sucrose erucate, and mixtures thereof; wherein the promoter is a member selected from the group consisting of amino acid derivatives, aminosugars, and mixtures thereof; and wherein the protector is a member selected from the group consisting of carbomers, carboxymethylcellulose, polysaccharides, pectin, cellulose, dextrin, gelatin, polyethylene oxide, poly(vinyl alcohol), poly(vinyl propylene), poly(vinylpyrrolidone), xanthan gums, sodium alginate, methacrylic acid copolymers, colloidal silica, synthetic silica, water-soluble cellulose ethers, hydroxypropylmethacrylates, tragacanth, water-soluble chitosan, polycarbophil, derivatives thereof, and mixtures thereof.