Patent ID: 8664198
Filing Date: 2014-03-04
Classification: A61K,A61N,A61P,B82Y,C12N,Y10S

Abstract:
1. A method of photoimmunological therapy for inducing tumor cell destruction and anti-tumor immune responses comprising: internalizing immunologically modified nanostructures in a body of the tumor cell in a host, said immunologically modified nanostructures comprised of single-walled carbon nanotubes bound to glycated chitosan; exposing said tumor cell to either continuous near-infrared light or radiofrequency radiation for providing thermal damage or stress, thereby leading to death of the tumor cell and exposure of tumor antigens of said tumor cell to an immune system of said host for promoting anti-tumor immune responses; wherein said glycated chitosan solubilizes and stabilizes said nanotubes; wherein said steps of internalizing and exposing induce a synergistic, spatially and temporally synchronized photothermal-immunological anti-tumor response using the immunologically modified nanostructures as an exogenous light-absorbing agent and the immunological stimulant for immune stimulation and activation.