Patent ID: 8815975
Filing Date: 2014-08-26
Classification: A61L

Abstract:
1. A liquid cyanoacrylate tissue adhesive/sealant formulation comprising: a mixture of n-butyl cyanoacrylate and methoxypropyl cyanoacrylate or ethyl cyanoacrylate and methoxypropyl cyanoacrylate at a weight ratio ranging between 50/50 and 90/10; at least one carboxylic acid-bearing C-succinylated heterochain polymeric modifier which is a triaxial segmented copolyester comprising ε-caprolactone, trimethylene carbonate, l-lactide, and glycolide in a molar ratio of 35/14/34/17, the triaxial segmented copolyester being made by the step of reacting the triaxial segmented copolyester with maleic anhydride under free-radical conditions to introduce succinic anhydride side groups onto the main chain and half-ester end-groups, followed by the step of selective hydrolysis of the anhydride side group to yield succinic acid side groups; at least 2 ppm of an acidic or acid producing compound; less than 1000 ppm of a free-radical scavenger; and wherein the C-succinylated heterochain polymeric modifier is capable of increasing the viscosity of the liquid formulation by at least 5 percent relative to the mixture of n-butyl cyanoacrylate and methoxypropyl cyanoacrylate or ethyl cyanoacrylate and methoxypropyl cyanoacrylate alone, shielding against premature anionic polymerization of cyanoacrylate monomers, and increasing the compliance of the cured formulation.