Patent ID: 6913779
Filing Date: 2005-07-05
Classification: A61K

Abstract:
1. A process for impregnating a cross-linked polymer with an active ingredient to obtain accelerated release pharmaceutical formulations, comprising the following steps, carried out in the order indicated: a. swelling a cross-linked polymer with a solution of the active ingredient in an organic solvent, wherein said organic solvent is capable of dissolving the active ingredient but not the polymer and has swelling properties towards the polymer; b. adding, into a closed reactor, to the swollen polymer/active ingredient/solvent mixture obtained in step a) a compressed fluid, which is an antisolvent for the active ingredient, until reaching a pressure equal to or higher than the precipitation pressure of said active ingredient, thereby causing precipitation of the active ingredient into the polymer; c. removing the organic solvent from the reactor while maintaining the pressure at values equal to or higher than the precipitation pressure of said active ingredient; and d. removing the compressed fluid from the reactor.