Patent ID: 6677153
Filing Date: 2004-01-13
Classification: A61K,A61P,C12N,Y02A

Abstract:
A method of inhibiting growth of bacteria selected from the group consisting of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecium, and Salmonella typhimurium, comprisingcontacting said bacteria in vitro with an effective amount of an antisense morpholino oligomer containing from 10 to 40 nucleotide subunits, each of said subunits comprising a morpholino ring supporting a base-pairing moiety effective to bind by Watson-Crick base pairing to a respective nucleotide base, said base-pairing moieties including a targeting nucleic acid sequence at least 10 nucleotides in length which is complementary to a 16S or 23S rRNA nucleic acid sequence of said bacteria, wherein adjacent subunits are joined by uncharged phosphorodiamidate linkages.