Patent ID: 6187771
Filing Date: 2001-02-13
Classification: A01N,A61K,A61P,C07K

Abstract:
A method for treating an autoimmune disease comprising administering an effective amount of a compound, or a pharmaceutical composition containing the compound, to a patient in need of such treatment, wherein the compound has the following formula: ##STR49##wherein:n is 1 or 2;m is 1 or 2;A is R.sup.2 CO--, R.sup.3 --O--CO--, or R.sup.4 SO.sub.2 --,or a group of the formula: ##STR50##R.sup.1 is a hydrogen atom, alkyl or phenylalkyl,R.sup.2 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, or (five- or six-membered heteroaryl)alkyl;R.sup.3 is alkyl, cycloalkyl (cycloalkyl)alkyl, phenylalkyl, or (mono- or di-substituted phenyl)alkyl;R.sup.4 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, or (five- or six-membered heteroaryl)alkyl;R.sup.5 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, or (five- or six-membered heteroaryl)alkyl;R.sup.6 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenylalkyl or (mono- or di-substituted phenyl)alkyl;R.sup.7 is alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, or (five- or six-membered heteroaryl)alkyl; andR.sup.8 is an amino acid side chain of a naturally occurring .alpha.-amino acid or a non-protein .alpha.-amino acid; andB is a hydrogen atom, a deuterium atom, alkyl, cycloalkyl, (cycloalkyl)alkyl, phenyl, phenylalkyl, substituted phenyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, (five- or six-membered heteroaryl)alkyl, or halomethyl;a group of the formula:--CH.sub.2 XR.sup.9 ;a group of the formula:--CH.sub.2 --O--CO-- (five- or six-membered heteroaryl); ora group of the formula:--CH.sub.2 --O--PO--(R.sup.10)R.sup.11 ;R.sup.9 is phenyl, substituted phenyl, phenylalkyl, (mono- or di-substituted phenyl)alkyl, five- or six-membered heteroaryl, or (five- or six-membered heteroaryl)alkyl; and X is an oxygen or a sulfur atom; andR.sup.10 and R.sup.11 are independently alkyl, cycloalkyl phenyl, substituted phenyl, phenylalkyl, or (mono- or di-substituted phenyl)alkyl;or a pharmaceutically-acceptable salt thereof.