Patent ID: 6300522
Filing Date: 2001-10-09
Classification: C07C

Abstract:
A process for the preparation of a compound of Formula (1): ##STR9##wherein:X.sup.1 and X.sup.2 are each independently H, Cl or F, provided that at least one of X.sup.1 andX.sup.2 is Cl or F;one of R.sup.1 and R.sup.2 is H and the other is OH; andR.sup.5 is an unsubstituted alkyl, comprising the steps:(a) condensing a 2-chloroalkanoic acid with an optionally substituted benzyl alcohol to form a 2-(optionally substituted benzyloxy) alkanoic acid;(b) converting the product from step (a) to the corresponding acid chloride; then either:(c) reacting the product of step (b) with a compound of the Formula (2) in the presence of a source of copper (I) to give a compound of Formula (3) wherein one of R.sup.3 and R.sup.4 is H and the other is optionally substituted benzyloxy; ##STR10##(d) reacting the product of step (b) with a compound of Formula (4):A--NH--Bwherein A and B independently represent substituted alkyl, alkoxy, aryl or oxyaryl groups, or are linked to form a heterocyclic ring to form an amide, and then reacting the amide with a compound of Formula (2) to give a compound of Formula (3); and(e) removing the optionally substituted benzyl group from the compound of Formula (3) by hydrogenation, thereby giving the compound of Formula (1).