Patent ID: 6809221
Filing Date: 2004-10-26
Classification: C07B,C07C

Abstract:
A process for making (+)-cis-sertraline hydrochloride from (Â±)-sertraline base comprising the steps of:(a) hydrogenating sertraline-1-imine at a temperature of at least about 40Â° C. using a catalyst selected from the group consisting of palladium and platinum to obtain (Â±)-sertraline base having a cis/trans ratio of greater than about 3:1; (b) reacting an optically active selective precipitant with (Â±)-sertraline base to form a (+)-cis-sertraline-precipitant; (c) reacting the (+)-sertraline-precipitant with a basic solution to facilitate the formation of the (+)-sertraline base; (d) reacting the (+)-sertraline base with hydrochloric acid to facilitate the precipitation of (+)-cis-sertraline hydrochloride; and (e) isolating (+)-cis-sertraline hydrochloride.