Patent ID: 7923535
Filing Date: 2011-04-12
Classification: A61K,A61P,C07H,C07K,C12N,C12P

Abstract:
1. A substituted human defensin polypeptide, comprising : (i) a tryptophan residue or a phenylalanine residue substituted for at least one arginine residue in a corresponding non-substituted human alpha-defensin or human beta-defensin polypeptide; (ii) six conserved cysteine residues that form three disulfide bonds; (iii) decreased cytotoxic activity, compared to the corresponding non-substituted human defensin polypeptide; and (iv) increased polypeptide stability, compared to the corresponding non-substituted human defensin polypeptide, wherein the at least one arginine residue in the corresponding non-substituted human defensin polypeptide is ADP-ribosylated, wherein the polypeptide is no more than 94 amino acids in length and retains anti-microbial activity.