Patent ID: 6677450
Filing Date: 2004-01-13
Classification: A61P,C07H

Abstract:
A compound of Formula (I) or a pharmaceutically acceptable addition salt or solvate thereof, wherein:R is hydrogen, OH, OC1-7alkyl, NH2, N(C1-3alkyl)2, or C1-7alkyl, wherein said C1-7alkyl or C1-3alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN SR9, OR9 and NR9R10; R1, R2 and R3 are each independently selected from the group consisting of hydrogen, C1-7alkenyl, C3-7cycloalkyl, halogen, azido, NR9R10, NHC(O)NR9R10, NHC(O)OR9, C(O)OR9, SR9 and OR9, wherein said C1-7alkenyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, SR9, OR9 and NR9R10; provided that no more than two of the variables selected from the group consisting of R1 R2 and R3 may be C3-7cycloalkyl, azido, NHC(O)NR9R10 or NHC(O)OR9; R7 and R8 are independently OH or H or R7 and R8 together form &boxH;O; R9 and R10 are independently selected from the group consisting of hydrogen, C1-7alkyl and C3-7cycloalkyl, wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OH, O-C1-7alkyl, NH2 and N(C1-3alkyl)2; or R9 and R10 together with the nitrogen atom to which they are attached form a non-aromatic 5-8 membered heterocycle containing one or two of the same or different heteroatoms selected from the group consisting of O, N and S; and X1, X1â€², X2 and X2â€² are independently selected from the group consisting of hydrogen, halogen, cyano, OR9, â€”CF3, alkylcarbonyl, C-1-7alkyl, nitro, alkoxyaminoalkyl, NR9R10, SR9 and C(O)OR9; wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OR9, SR9 and NR9R10, wherein at least one of X1 and X2 is F and at least one of X1â€² and X2â€² is F.