Patent ID: 6107309
Filing Date: 2000-08-22
Classification: C07D

Abstract:
A compound of Formula (I) ##STR15## wherein: R.sub.1 is independently a 4-10 membered mono- or bicyclic heterocyclic ring system containing up to four heteroatoms N, O, S in the ring in which at least one heteroatom is N, and wherein the ring is substituted or unsubstituted by one or two C.sub.1-4 alkyl, F, Cl, Br, I, C.sub.1-4 alkoxy, (CH.sub.2).sub.m R.sub.6, oxo, oxime, O-C.sub.1-4 alkyloxime, hydroxy, N(R.sub.5).sub.2, acylamino or aminoacyl groups, 8, 9, 10 membered moncyclic ring sytems being excluded;R.sub.2 is independently hydrogen, C.sub.1-4 alkylC(O)R.sub.6, C.sub.1-4 alkyl or R.sub.2 is benzyl which is optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, I, Br, OH, or N(R.sub.5).sub.2 ;Y is (CH.sub.2).sub.n, in which at least one carbon is gem-substituted by R.sub.3 and R.sub.4 ;R.sub.3 and R.sub.4 are independently C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl; all of which may be substituted by one or two C.sub.1-4 alkyl, OH, F, Cl, Br, I, N(R.sub.5).sub.2, (R.sub.5).sub.2 NC(O)--, --(CH.sub.2).sub.m R.sub.6, --(CH.sub.2).sub.m R.sub.5, --(CH).sub.2).sub.m COR.sub.6, or --(CH.sub.2).sub.m C(O)R.sub.5 ; or R.sub.3 and R.sub.4 are F, Cl, or Br; or R.sub.3 and R.sub.4 may together form a cyclic or heterocyclic ring of Formula (Ia): ##STR16## in which p and q are independently an integer from 0 to 3; X is O, S, CH.sub.2 or N(R.sub.5);R.sub.5 is independently hydrogen, C.sub.1-4 alkyl, or benzyl;R.sub.6 is independently OR.sub.5, N(R.sub.5).sub.2 or SR.sub.5 ; andn is an integer from 3 to 8;m is an integer from 0 to 4;or a pharmaceutical acceptable salt thereof;provided:p and q are not both 0; andwhen R.sub.3 and R.sub.4 are F, Cl or Br, they are not on a carbon adjacent to the nitrogen.