Patent ID: 6399642
Filing Date: 2002-06-04
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinR1 and R2 are each independently hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C6)cycloalkyl(C1-C6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, trifluoromethoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, (C1-C6)alkanoyloxy, aryl, heteroaryl, aryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl; or R1 and R2 taken together are methylenedioxy; or R1 and R2 taken together are benzo; R3, R4, and R5 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C2-C6)alkanoyloxy, aryl, heteroaryl, aryl(C1-C6)alkyl, and heteroaryl(C1-C6)alkyl; R6 and R7 are each independently hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C6)ycloalkyl(C1-C6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, trifluoromethoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, or (C1-C6)alkanoyloxy; R8 is hydroxy, halo, nitro, cyano, mercapto, carboxy, (C1-C6)alkoxy, (C3-C6)cycloalkyl(C1-C6)alkoxy, â€”NRaRb, halo(C1-C6)alkyl, trifluoromethoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, (C1-C6)alkanoyloxy, aryloxy, or heteroaryloxy; or R8 is (C1-C6)alkyl substituted by 1, 2, or 3 substituents independently selected from the group consisting of hydroxy, nitro, cyano, mercapto, carboxy, (C1-C6)alkoxy, (C3-C6)cycloalkyl(C1-C6)alkoxy, â€”NRaRb, trifluoromethoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, (C1-C6)alkanoyloxy, aryloxy, and heteroaryloxy; and each Ra and Rb is independently hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, arylcarbonyl, or heteroarylcarbonyl; or Ra and Rb together with the nitrogen to which they are attached are pyrrolidino, piperidino, or morpholino. wherein any aryl, heteroaryl, or benzo of R1-R5, R8, Ra, and Rb may optionally be substituted by 1, 2, or 3 substituents independently selected from the group consisting of (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C6)cycloalkyl(C1-C6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C1-C6)alkyl, halo(C1-C6)alkyl, trifluoromethoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C1-C6)alkanoyloxy; or a pharmaceutically acceptable salt thereof.