Patent ID: 6235928
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: ##STR25##or a salt thereof, wherein:R.sub.1 isa) C.sub.4-12 alkyl,b) C.sub.4-12 alkenyl,c) C.sub.4-2 alkynyl,d) --(CH.sub.2).sub.h --C.sub.3-8 cycloalkyl,e) --(CH.sub.2).sub.h -aryl,f) --(CH.sub.2).sub.h -aryl substituted with C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halo, --NO.sub.2, --CF.sub.3, --CN, or N(C.sub.1-4 alkyl).sub.2,g) --(CH.sub.2).sub.h -het, orh) --(CH.sub.2).sub.h -het substituted with C.sub.1-4 alkyl, or halo; andR.sub.2 isa) C.sub.4-12 alkyl;b) C.sub.1-12 alkyl substituted with one to three halo, --CN, --NO.sub.2, --CF.sub.3, --N(R.sub.3).sub.2, --SR.sub.3, or OH,c) C.sub.2-12 alkenyl,d) C.sub.2-12 alkenyl substituted with one to three halo, --CN, --NO.sub.2 or --CF.sub.3,e) C.sub.2-12 alkynyl,f) C.sub.2-12 alkynyl substituted with one to three halo, --CN, --NO.sub.2, or --CF.sub.3,g) --(CH.sub.2).sub.h --C.sub.3-8 cycloalkyl,h) --(CH.sub.2).sub.h --C.sub.3-8 cycloalkyl substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or halo,i) --(CH.sub.2).sub.h --C.sub.3-8 cycloalkenyl,j) --(CH.sub.2).sub.h --C.sub.3-8 cycloalkenyl substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or halo,k) --(CH.sub.2).sub.h -aryl, wherein h is 0 or 2-6,l) --(CH.sub.2).sub.h -aryl substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --CF.sub.3, --OH, --NO.sub.2, --CN, --N(R.sub.3).sub.2, --SR.sub.3, --SO.sub.2 (C.sub.1-4 alkoxy), --C(.dbd.O)R.sub.3, or --NC(.dbd.O)R.sub.3,m) --(CH.sub.2).sub.h -aryl substituted with one to five halo,n) --(CH.sub.2).sub.h -het,o) --(CH.sub.2).sub.h -het substituted with one to two C.sub.1-4 -alkyl, or halo,p) --(CH.sub.2).sub.h -Q,q) --(CH.sub.2).sub.h -Q substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halo, or phenyl,r) --(CH.sub.2).sub.i --X--R.sub.4, wherein the --(CH.sub.2).sub.i -chain is unsubstituted or substituted with C.sub.1-4 alkyl or phenyl, which is unsubstituted or substituted with one to three halo or C.sub.1-4 alkyl, ors) --(CH.sub.2).sub.i CHR.sub.5 R.sub.6,wherein:R.sub.3 is:H,C.sub.1-4 alkyl,--(CH.sub.2).sub.h -phenyl, or--(CH.sub.2).sub.h -phenyl substituted with one to three C.sub.1-4 alkyl C.sub.1-4 alkoxy, or halo;R.sub.4 is:H,C.sub.1-4 alkyl,--(CH.sub.2).sub.h -phenyl,--(CH.sub.2).sub.h -phenyl substituted with one to three C.sub.1-4 alkyl C.sub.1-4 alkoxy, halo,--NO.sub.2, or --CN; or--(CH.sub.2).sub.h -het;R.sub.5 is:C.sub.1-4 alkyl, or--C(.dbd.O)R.sub.3 ;R.sub.6 is:--C(.dbd.)R.sub.3, or--(CH.sub.2).sub.h C(.dbd.O)R.sub.3,wherein ""het"" is a 5- to 10-membered unsaturated heterocyslic moiety having one to three atoms selected from the group consisting of oxygen, nitrogen and sulfur;wherein ""Q"" is a 5- to 10-membered saturated heterocyclic moiety having one or two atoms selected from the group consisting of oxygen, nitrogen and sulfur;wherein ""X"" is:--O----S(.dbd.O).sub.j ----NR.sub.7 --, wherein R.sub.7 is:H,C.sub.1-4 alkyl,--(CH.sub.2).sub.h -phenyl,--(CH.sub.2).sub.h -phenyl substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or halo,--C(.dbd.O)--R.sub.3,--S(.dbd.O).sub.2 R.sub.3, or--C(.dbd.O)OR.sub.3,--S(.dbd.O).sub.2 NR.sub.8 --wherein R.sub.8 is:--C.sub.1-4 alkyl,--(C.sub.2).sub.h -phenyl, or--(CH.sub.2).sub.h -phenyl substituted with one to three C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or halo; or--C(.dbd.O)--; and wherein""h"" is 0,1,2,3,4,5 or 6;""i"" is 0,1,2,3,4,5,6,7,8,9, or 10; and""j"" is 0, 1 or 2.