Patent ID: 6462193
Filing Date: 2002-10-08
Classification: C07D,G11C,H01L

Abstract:
A method for producing a tetrahydroxyazepane which comprises the following steps:step (a): adding 3-azido-2-hydroxypropanaldehyde with dihydroxyacetone phosphate using an aldolase for producing a 6-azido-3,4,5-trihydroxy-2-hexanone-1-phosphate intermediate having an anion represented by the formula: step (b): hydrolyzing the 6-azido-3,4,5-trihydroxy-2-hexanone-1-phosphate intermediate formed in said step (a) with acid phosphatase for producing a polyhydroxy 6-deoxy-6-azido ketose intermediate with the formula: step (c): isomerizing the polyhydroxy 6-deoxy-6-azido ketose intermediate formed in said step (b) with an isomerase for producing a 6-azido-6-deoxyaldose intermediate with the formula: step (d): cyclizing the 6-azido-6-deoxyaldose intermediate formed in said step (c) using reductive amination conditions with hydrogen and a catalyst for producing the tetrahydroxyazepane with the formula: