Patent ID: 6812230
Filing Date: 2004-11-02
Classification: A61K,A61P

Abstract:
A method of treating progressive renal fibrosis in a mammal which method comprises administering to a mammal in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a non-peptide CCR1 receptor antagonist, wherein the non-peptide CCR1 receptor antagonist is a compound selected from formula (I): whereinR1a is one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl; R2 is fluoro at the 4-position; R3 is phenyl substituted at the 4-position with chloro and at the 2-position by aminocarbonyl, ureido or glycinamido; R4 is â€”Oâ€”; R5 is methylene; and R6 is â€”C(O)â€”, a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.