Patent ID: 7915015
Filing Date: 2011-03-29
Classification: C12Q

Abstract:
1. A method for determining an allelic imbalance in a biological sample, comprising the steps of: amplifying template molecules within a set comprising a plurality of assay samples to form a population of amplified molecules in each of the assay samples of the set, wherein the template molecules are obtained from the biological sample; analyzing the amplified molecules in the assay samples of the set to determine a first number of assay samples which contain a first allelic form of a marker and a second number of assay samples which contain a second allelic form of the marker, wherein between 0.1 and 0.9 of the assay samples yield an amplification product; comparing the first number to the second number to ascertain an allelic imbalance in the biological sample; and identifying an allelic imbalance in the biological sample.