Patent ID: 6083982
Filing Date: 2000-07-04
Classification: A61K,A61P,C07C,C07D

Abstract:
A natriuretic compound having the formula IIa ##STR43## wherein R.sub.1 and R.sub.2 independently are H, OH, alkyl, aryl, alkenyl, alkynyl, aromatic, ether, ester, unsubstituted or substituted amine, amide, halogen or unsubstituted or substituted sulfonyl, or jointly complete a 5- or 6-member aliphatic or aromatic ring,R.sub.3 is H, OH, alkyl, aryl, alkenyl, alkynyl, aromatic, ether, ester, unsubstituted or substituted amine, amide, halogen or unsubstituted or substituted sulfonyl, or jointly complete a 5- or 6-member aliphatic, aromatic or heterocyclic ring,R.sub.4 is H;R.sub.5 is H, OH, alkyl, aryl, alkenyl, alkynyl, aromatic, ester or unsubstituted or substituted amine,R.sub.6 is COOH, COOR.sub.7, CONH.sub.2, CONHR.sub.7, CONR.sub.7 R.sub.8, NH.sub.2, NHR.sub.7, NR.sub.7 R.sub.8, or a carboxylate salt,R.sub.7 and R.sub.8 independently are unsubstituted or substituted alkyl, aryl, alkaryl, aralkyl, alkenyl or alkynyl,R.sub.9 is hydroxyl or unsubstituted or substituted alkoxyl,n is 0 to 3, andm is 0 to 5.