Patent ID: 6127173
Filing Date: 2000-10-03
Classification: A61K,C12N

Abstract:
A nucleic acid molecule with an endonuclease activity having the formula I: ##STR2## wherein, each N represents independently a nucleotide or an abasic moiety, which may be same or different; X and Y are independent oligonucleotides of length sufficient to stably interact with a target nucleic acid molecule; m and n are integers greater than or equal to 1, wherein if (N).sub.m and (N).sub.n are nucleotides, (N)m and (N)n may interact by hydrogen bond interaction; J is an oligonucleotide having a sequence selected from the group consisting of 5'-GGCAUCC-3', 5'-AGCAUU-3', 5'-GCAUCA-3', 5'-AGCAUC-3', and, 5'-AGCGUC-3'; L is a linker which may be present or absent, wherein said linker, when present, is a nucleotide linker or a non-nucleotide linker, or a combination of nucleotide and a non-nucleotide linker, wherein said nucleotide linker comprises a single-stranded region, or double-stranded region, or a combination of single-stranded and a double-stranded region; represents a chemical linkage; and C and G represent cytidine and guanosine nucleotides, respectively.