Patent ID: 6693118
Filing Date: 2004-02-17
Classification: A61K,A61P

Abstract:
A method of inhibiting apoptosis in a patient which comprises administering an effective amount of a compound of formula (I): in which:R1 represents a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group; Y represents a nitrogen atom; Zâ€² and Zâ€³ each represent hydrogen or a (C1-C3) alkyl group, or one represents hydrogen and the other a hydroxy group, or both, together, represent an oxo group; Z represents a phenyl radical; a phenyl radical monosubstituted with a substituent X, X being a) a (C1-C6)alkyl; (C1-C6)alkoxy; (C3-C7)carboxyalkyl; (C1-C4) alkoxycarbonyl(C1-C6)alkyl; (C3-C7)carboxyalkoxy or (C1-C4)-alkoxycarbonyl (C1-C6)alkoxy group; b) a group selected from a (C3-C7)cycloalkyl, (C3-C7)cycloalkyloxy, (C3-C7) cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl group, it being possible for said group to be substituted with a halogen, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, amino, mono- or di-(C1-C4)alkylamino; c) a group selected from a phenyl, phenoxy, phenylamino, N-(C1-C3) alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulphonyl, phenylsulphinyl or styryl, it being possible for said group to be mono- or poly-substituted on the phenyl group with a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkylamino, (C1-C4)acylamino, carboxy, (C1-C4) alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4) alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4) alkyl or halo(C1-C4)alkyl; a phenyl radical disubstituted with a substituent R2, R2 being a halogen or a hydroxy, methyl, ethyl, (C3-C6)alkyl, (C1-C4)alkoxy or trifluoromethyl group and with a substituent X, X being as defined above; a 1-naphthyl or 2-naphthyl radical; a 1-naphthyl or 2-naphthyl radical substituted in positions 5, 6, 7 and/or 8 with one or two hydroxyl groups, one or two (C1-C4)alkoxy groups or a 6,7-methylenedioxy group; or Zâ€³ is hydrogen and Z and Zâ€² represent, each independently, a non-substituted or mono-, di- or tn-substituted phenyl group; or of one of its pharmaceutically acceptable salts and solvates.