Patent ID: 8969590
Filing Date: 2015-03-03
Classification: A61K,C07D

Abstract:
1. A compound that exhibits at least 50% autotaxin inhibition capability at a 10 μM concentration, said compound exhibiting at most 5 hydrogen bond donors, at most 10 hydrogen bond acceptors, and at most 10 rotatable bonds therein; wherein said compound further selected from the group consisting of a thiourea compound exhibiting a molecular weight of at most 527, an isoindole compound exhibiting a molecular weight of at most 648, a diphenyldiazerene exhibiting a molecular weight of at most 500, and a xanthene exhibiting a molecular weight of at most 557; and wherein said compound meets all extended flexibility metrics of Lipinski's rules for biological distribution, wherein said at least one compound is selected from the group consisting of at least one of the following: