Patent ID: 7135570
Filing Date: 2006-11-14
Classification: C07D

Abstract:
1. A process for synthesizing an enantiomer of a primary amino-substituted fused bicyclic ring of formula IX comprising: a) forming the Schiff base of a keto group located on ring B of the fused bicyclic ring by reacting it with an enantiomerically-pure primary amine chiral auxiliary R*NH to produce the corresponding enantiomerically-pure imine of the fused bicyclic ring; b) diastereoselectively reducing the imine to produce the corresponding enantiomerically-pure secondary amine on the fused bicyclic ring; and c) removing the chiral auxiliary R* to form the enantiomer of the primary amino-substituted fused bicyclic ring; wherein ring A is a heteroaromatic 5- or 6-membered ring, P is a nitrogen atom, sulfur atom or oxygen atom; ring B is a 5- or 6-membered cycloalkyl or heterocycloalkyl; wherein NH wherein m is 0–4; R R