Patent ID: 7202367
Filing Date: 2007-04-10
Classification: C07D

Abstract:
1. A process for N-arylating, or N-vinylating a nucleophilic compound consisting of a five membered heterocyclic ring containing nitrogen, selected from the group consisting of pyrrole, imidazole, pyrazole, triazole, indole, and tetrazole, comprising the steps of: a) reacting the nucleophilic compound with a compound with a leaving group according to formula (IV): wherein: Y is a leaving group, and R a metallic element M selected from the group consisting of the elements of the groups (VIII), (Ib) and (IIb) of the periodic table, and at least one ligand comprising at least one imine group and at least one further nitrogen atom, as a chelating atom, selected from the following formulae Ia wherein, one of the groups R R R R wherein: R R Ψ represents a group of formula —HN—CO—NH— or a skeleton having one of the following formulae (F wherein: R R Ar x and y respectively represent the two bonds between the skeleton shown as ψ and the imine groups; and wherein: R Φ represents: a residue of a monocyclic or polycyclic hydrocarbon cycle containing 5 to 12 carbon atoms carrying the two imine functions in the ortho or meta position; and b) recovering the N-arylated or N-vinylated nucleophilic compound obtained in step a).