Patent ID: 6495335
Filing Date: 2002-12-17
Classification: C07K,G01N

Abstract:
A method for detecting at least one modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, comprising the steps of:a) providing: i) a sample suspected of containing at least one modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, and ii) a purified antibody directed against a modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct; b) contacting said sample with said antibody under conditions such that said antibody binds to said modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, to form an antigen-antibody complex; and c) detecting the presence of said antigen-antibody complex.