Patent ID: 8324351
Filing Date: 2012-12-04
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A polypeptide comprising a variant Fc region of a parent Fc polypeptide comprising amino acid substitutions at positions 311 and 434 wherein said variant Fc region is selected from the group consisting of: (i) a variant Fc region comprising an isoleucine that is not a wild-type amino acid at position 311 and a serine that is not a wild-type amino acid at position 434, and (ii) a variant Fc region comprising a valine that is not a wild-type amino acid at position 311 and a serine that is not a wild-type amino acid at position 434, wherein said polypeptide is an antibody or an immunoadhesin and wherein numbering is according to the EU Index in Kabat et al.