Patent ID: 8372973
Filing Date: 2013-02-12
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): wherein: A L s is an integer of 1 to 3; X is O or S; D is -P-A wherein P is —(CH A provided that A W is C(R Q is selected from the group consisting of (a) to (g), wherein (a) is —NH(CH provided that when Ar (b) is —NHCH(R 1,2,3,4-tetrahydro-[1,8]naphthyridinyl, imidazo[1,2-a]pyridinyl, or quinolinyl; such that the point of attachment to 1,2,3,4-tetrahydro-[1,8]naphthyridinyl is at the 6 or 7 position, and the point of attachment to quinolinyl is at the 2, 3, or 4-position; and wherein Ar wherein the C and wherein pyridin-2-yl and pyridin-3-yl are optionally further substituted with N-pyrrolidinyl, N-piperazinyl, N-piperidinyl, N-morpholinyl, N-thiomorpholinyl, —CH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH provided that when Q is —NHCH and, provided that when Q is —NHCH (c) is —CH and wherein the C (d) is —(CH and wherein the C (e) is —CH═CH—Ar and wherein the C (f) is —O—CH(R wherein Ar and wherein the C provided that when Q is —O—CH(R and (g) is —X wherein Ar and wherein the C wherein a nitrogen atom of Ar and an enantiomer, a diastereomer, a tautomer, or a pharmaceutically acceptable salt thereof.