Patent ID: 6326386
Filing Date: 2001-12-04
Classification: A61K,C07D

Abstract:
A compound represented by formula (I) ##STR19##whereR.sup.1 and R.sup.2 independently represent a group ##STR20##or R.sup.1 and R.sup.2 together form a C.sub.3-7 heterocycloalkyl or heterocycloalkenyl group which may be optionally substituted by C.sub.1-6 alkyl, C.sub.1-4 alkoxy, halogen, carboxylic acid or a C.sub.1-4 carboxylic acid ester group;R.sup.3 represents hydrogen, C.sub.1-3 alkyl, halogen, or C.sub.1-2 alkoxy;R.sup.4, R.sup.5 and R.sup.6 independently represent hydrogen, or halogen;R.sup.7 represents hydrogen or C.sub.1-6 alkyl;R8 represents hydrogen, C3-7 cycloalkyl, C3-7 cycloalkenyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkenyl, aryl, or heteroaryl, which groups are optionally substituted by one or more groups selected from halogen, hydroxy, CN, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 acyloxy, NR.sup.9 R.sup.10, NHCOR.sup.11, NHSO.sub.2 R.sup.12, COR.sup.3, CO.sub.2 R.sup.14, CONR.sup.15 R.sup.16, and SO.sub.2 NHR.sup.17 ;X represents a bond, a C.sub.1-6 alkyl chain, or a C.sub.3-6 alkenyl chain, where one or two nitrogen, oxygen, or sulfur atoms may be optionally contained within each chain, and the chains are optionally substituted by one or more groups selected from halogen, hydroxy, CN, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 acyloxy, NR.sup.9 R.sup.10, NHCOR.sup.11, NHSO.sub.2 R.sup.12, COR.sup.13, CO.sub.2 R.sup.14, CONR.sup.15 R.sup.16, and SO.sub.2 NHR.sup.17 ;R.sup.9 -R.sup.17 represent hydrogen, C.sub.1-6 alkyl, or R.sup.9 and R.sup.10 or R.sup.15 and R.sup.16 form a C.sub.3-7 heterocycloalkyl ring, or R.sup.12 additionally may represent trifluoromethyl;or pharmaceutically acceptable salt or solvate thereof.