Patent ID: 6555533
Filing Date: 2003-04-29
Classification: A61P,C07D

Abstract:
A method of treating tumors selected from the group consisting of breast, non-small cell lung, colon and prostate comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of formula I whereR1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C3-8)cycloalkyl; or an aromatic ring system selected from II, III, IV and V: â€ƒwhere R4 is hydrogen, chloro, or methoxy; R5 is hydrogen, chloro, (C1-18)alkyl or (C1-18)alkoxy; and Z is oxygen, sulfur, Nâ€”H, or Nâ€”CN3; or a pharmaceutically acceptable acid addition salt thereof, where possible.