Patent ID: 6407242
Filing Date: 2002-06-18
Classification: C07D,C09B,C09K,H05B

Abstract:
A preparation process of a quinoline compound and a tautomer of the same which are represented by the formula (4): wherein each of R51, R52, R53, R54, R55, R56, R57, R58, R59 and R60 is individually hydrogen atom, halogen atom, nitro, cyano, hydroxy, amino, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted N-alkylamino, substituted or unsubstituted N,N-dialkylamino, substituted or unsubstituted N-arylamino, substituted or unsubstituted N,N-diarylamino or substituted or unsubstituted N-alkyl-N-arylamino group, comprising reacting a quinoline derivative represented by the formula (5): wherein each of Y1, Y2, Y3, Y4, Y5 and Y6 is a hydrogen atom, halogen atom, nitro, cyano, hydroxy, amino, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted N-alkylamino, substituted or unsubstituted N,N-dialkylamino, substituted or unsubstituted N-arylamino, substituted or unsubstituted N,N-diarylamino or substituted or unsubstituted N-alkyl-N-arylamino group, and a phthalimide derivative represented by the formula (6): wherein each of Y7, Y8, Y9 and Y10 is individually a hydrogen atom, halogen atom, nitro, cyano, hydroxy, amino, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted N-alkylamino, substituted or unsubstituted N,N-dialkylamino, substituted or unsubstituted N-arylamino, substituted or unsubstituted N,N-diarylamino or substituted or unsubstituted N-alkyl-N-arylamino group, with zinc halogenide in an organic basic solvent and successively treating with an inorganic acid, wherein the phthalimide derivative is in a molar ratio of 1.1 to 2.0 to the quinoline derivative.