Patent ID: 7528251
Filing Date: 2009-05-05
Classification: A61P,C07B,C07C,C07D

Abstract:
1. Method for the enantioselective preparation of sulfoxide derivatives or of their salts, represented by the following formula: in which A is a pyridinyl nucleus diversely substituted and B a heterocyclic residue comprising an imidazo-pyridinyl nucleus, wherein an enantioselective oxidation of a sulphide of the following general formula (I) is performed in which A and B have the above-mentioned meanings, using an oxidizing agent in the presence of a titanium(IV)-based catalyst and a chiral ligand comprising a cyclic beta- or gamma-amino-alcohol, in solution in a polar aprotic solvent selected from the group consisting of N-methyl-pyrrolidone (NMP), dimethylformamide (DMF), dimethylacetamide (DMA), pyridine, and mixtures thereof, followed as necessary by a salification by a base.