Patent ID: 9061038
Filing Date: 2015-06-23
Classification: A61K,A61P,C07C

Abstract:
1. A method of administering to a subject in need thereof an effective amount of a doxorubicin active agent, said method comprising: simultaneously administering to said subject said effective amount of a doxorubicin active agent that is an anthracycline antibiotic in conjunction with an amount of a doxorubicin toxicity-reducing adjuvant effective to reduce toxicity of said doxorubicin active agent, wherein said doxorubicin toxicity-reducing adjuvant is a nitrone compound of formula (II): or a pharmaceutically acceptable salt thereof, or a spatial isomer thereof; wherein: R is hydrogen or a disulfide conjugate; L is —[C(R X′ is selected from the group consisting of no atom, NR Cy is selected from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloheteroalkyl, bicycloalkenyl, bicycloheteroalkenyl, bicycloaryl, or bicycloheteroaryl ring; R R R R one of R