Patent ID: 8216996
Filing Date: 2012-07-10
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A multimer comprising four extracellular domains of Programmed Cell Death-1 (PD-1), wherein each of said four extracellular domains comprise a region selected from (a) and (b): (a) residues 1-167 or residues 25-145 of full-length human PD-1, wherein the cysteine at position 93 is substituted by serine; and (b) residues 1-169 or residues 25-145 of full-length mouse PD-1, wherein the cysteine at position 83 is substituted by serine, and wherein said four extracellular domains are (i) serially-concatenated directly or with a peptide linker, or (ii) bound to a carrier via a non-peptide linker.