Patent ID: 7060818
Filing Date: 2006-06-13
Classification: C07D

Abstract:
1. A method for making a macrocyclic tetraamido compound comprising: protecting an amino portion of an amino carboxylic acid at a first temperature sufficient to form the protected amino carboxylic acid; without first isolating the protected amino carboxylic acid, mixing the protected amino carboxylic acid with a first solvent; without first isolating the protected amino carboxylic acid or the first solvent, converting the carboxylic acid portion of the protected amino carboxylic acid to an activated carboxylic acid to form a protected amino activated carboxylic acid derivative; without first isolating the protected amino activated carboxylic acid derivative, reacting the protected amino activated carboxylic acid derivative with a diamine in the presence of a second solvent and a base to form a protected diamide diamine intermediate; isolating the protected diamide diamine intermediate; deprotecting the diamide diamine intermediate; and, reacting the diamide diamine intermediate with an activated diacid to form the macrocyclic tetraamido compound having at least 11 atoms forming the macrocycle.