Patent ID: 6290712
Filing Date: 2001-09-18
Classification: A61K,A61P,C08B,C08L

Abstract:
A method of producing tumor specific antibodies in a tumor-bearing host, comprising the steps of:(a) simultaneously introducing a chromophore and an immunoadjuvant into a neoplasm by intratumor injection to obtain a conditioned neoplasm, said chromophore being suitable to generate thermal energy upon activation in the near-infrared or infrared wavelength range;(b) activating said chromophore with a laser of a wavelength in the near-infrared or infrared range to a degree sufficient to activate said chromophore to produce a photothermal reaction inducing neoplastic cellular destruction and generating fragmented neoplastic tissue and cellular molecules, said in situ vaccine comprising the amalgam of said fragmented tissue and cellular molecules and said immunoadjuvant;(c) allowing said vaccine to be dispersed systemically within the host to provoke the production of tumor specific antibodies; and(d) collecting said tumor specific antibodies.