Patent ID: 6485742
Filing Date: 2002-11-26
Classification: A61K,A61P

Abstract:
A process for producing a coated preparation comprising a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid;said process comprising adding the melted coat material dropwise to the core material with fluidizing the core material at a temperature not higher than the solidification temperature of the coat material in the presence of &bgr;-form seed crystals of the coat material to solidify the coat material to form at least one coating layer about the core material; or adding the melted coat material dropwise to the core material with fluidizing the core material at a temperature not higher than the solidification temperature of the coat material to solidify the coat material to form at least one coating layer about the core material, followed by adding said &bgr;-form seed crystals of the coat material to accelerate &bgr;-form crystallization of the coating layer.