Patent ID: 7942929
Filing Date: 2011-05-17
Classification: A61L,A61M,C08F,C08J,G02B,Y10T

Abstract:
1. A method of forming a surface modified medical device, the method comprising: providing a medical device having at least one group providing reactive functionality on at least one surface of the medical device; providing a surface modifying agent comprising a reactive segmented block copolymer comprising a hydrophilic block and a chemical binding unit block having reactivity that is complimentary to the at least one group providing surface functionality of the medical device; contacting the at least one surface having reactive functionality of the medical device with the surface modifying agent, and; subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the device surface and the surface modifying agent to form a surface modified medical device, wherein the reactive segmented block copolymer is selected from the following formulae (I)-(III): wherein R1 is a reactive residue of a moiety capable of acting as an initiator for atom transfer radical polymerization, A is a chemical binding unit block, B is a hydrophilic unit block, m is 1 to 10,000, n is 1 to 10,000, p and q are natural numbers, and X is a halogen capping group of an initiator for atom transfer radical polymerization or a derivatized reaction product, wherein R1 is a radical forming residue of a reverse addition fragmentation transfer agent or free radical initiator, A is a chemical binding unit block, B is a hydrophilic unit block, m is 1 to 10,000, n is 1 to 10,000, p and q are natural numbers, and R2 is a thio carbonyl fragment of a chain transfer agent or a derivatized reaction product, and wherein R1 is a radical forming residue of a reverse addition fragmentation transfer agent or free radical initiator, A is a chemical binding unit block, B is a hydrophilic unit block, m is 1 to 10,000, n is 1 to 10,000, p and q are natural numbers, and R2 is a thio carbonyl thio group.