Patent ID: 6548652
Filing Date: 2003-04-15
Classification: C07B,C07F,C07H,C40B

Abstract:
A derivatized solid support of formula (iii) or of formula (v): whereinthe subscript n is an integer of from 1 to 30; the subscript m is an integer of from 1 to 30; R3 is a member selected from the group consisting of H, C1-C6alkyl and C3-C6cycloalkyl; â€”XH2 is a member selected from the group consisting of â€”NHâ€”C&boxH;(U)â€”NHNH2, â€”NHâ€”NHâ€”C&boxH;(U)â€”NHNH2 and â€”Uâ€”NHâ€”C&boxH;(U)â€”NHNH2, wherein each U is independently selected from the group consisting of O and S; Q is a member selected from the group consisting of substituted and unsubstituted carbocyclic aromatic rings and heteroaromatic rings; when the derivatized solid support has the formula (iii), T is a valence bond or a linker having a length of 1 to 100 atoms, containing carbon to carbon bonds, and optionally carbon to oxygen bonds and optionally including one or more moieties selected from the group consisting of â€”NHâ€”, â€”Oâ€”, â€”NHâ€”C(&boxH;O)â€”, â€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;S)â€”NHâ€”, â€”Sâ€” and â€”Sâ€”Sâ€”, â€”XH2; and when the derivatized solid support has the formula (v), T is a linker having a length of 1 to 100 atoms containing carbon to carbon bonds, and optionally carbon to oxygen bonds and optionally including one or more moieties selected from the group consisting of â€”NHâ€”, â€”Oâ€”, â€”NHâ€”C(&boxH;O)â€”, â€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;O)â€”NHâ€”, â€”NHâ€”C(&boxH;S)â€”NHâ€”, â€”Sâ€” and â€”Sâ€”Sâ€”, with the proviso that said linker has a carbon atom adjacent to â€”XH2.