Patent ID: 6294666
Filing Date: 2001-09-25
Classification: C07H

Abstract:
A method of preparing a compound of formula (I) ##STR10##the method comprising:reacting a compound of formula (II) ##STR11##with a hydroborating reagent to form a borane-containing intermediate; andreacting the borane-containing intermediate with a hydroperoxide in a basic aqueous medium; wherein each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, independently, is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, alkoxy, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, or alkyloxyalkyl, provided that R.sup.1 and R.sup.2, optionally form a keto or, with the carbon atom to which they are attached, optionally form a cyclic moiety, and that R.sup.3 and R.sup.4, optionally form a keto or, with the carbon atom to which they are attached, optionally form a cyclic moiety.