Patent ID: 8933015
Filing Date: 2015-01-13
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A method for treating a viral infection caused by a Hepatitis C virus in a human patient comprising administering to the human patient in need thereof a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt or a pharmaceutical composition thereof, wherein: X each R each R A is O, S(O) each n is independently 0, 1 or 2; each R R each R each R each R each R provided that each R provided that when R A A R each R wherein when R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , R 8b , R 9b , R 12 , R 16 , A, A 1 or A 2 is substituted, the substitutent is, independently, one or more substituents selected from the group consisting of halo, CN, CF 3 , N 3 , N(R a ) 2 , SR a , OR a , R a , NHCOR a , NHC(O)OR a , NHC(O)N(R a ) 2 , NHC(NR a )R a , NHC(NR a )N(R a ) 2 , C(O)R a , C(O)N(R a ) 2 , CO 2 R a , S(O) 2 OR a , S(O) 2 N(R a ) 2 , NHS(O) 2 OR a , NHS(O) 2 N(R a ) 2 , OP(O)(OR a ) 2 , OP(O)(OR a )(N(R a ) 2 ), NHP(O)(OR a ) 2 and NHP(O)(OR a )(N(R a ) 2 ).