Patent ID: 6506757
Filing Date: 2003-01-14
Classification: A61K,C07C,C07D

Abstract:
A method for treatment in animals of diseases induced by a peroxisome proliferator activated receptor, which comprises administering to a subject in need thereof an effective amount of the compound of formula (I) whereinA1 is C1Ëœ4 alkylene or C2Ëœ4 alkenylene, A2 is â€”Oâ€” or â€”Sâ€”, A3 is CH, n is 1Ëœ5, R1 is (i) hydrogen, (ii) C1Ëœ8 alkyl, (iii) halogen, (iv) C1Ëœ4 alkoxy, (v) nitro, (vi) trihalomethyl, (vii) trihalomethoxy, (viii) trihalomethylthio, (ix) cyano, (x) C1Ëœ4 alkylthio, (xi) NR5R6 wherein R5 and R6 are each independently hydrogen or C1Ëœ4 alkyl, (xii) carbocyclic ring or (xiii) hetero ring, R2 is (i) hydrogen, (ii) C1Ëœ4 alkyl, (iii) halogen or (iv) trihalomethyl, Cyc1 is CYc2 is (i) a carbocyclic ring or (ii) a hetero ring, R3 is (i) hydrogen, (ii) C1Ëœalkyl, (iii) halogen, (iv) C1Ëœ4 alkoxy, (v) nitro, (vi) trihalomethyl, (vii) trihalomethoxy, (viii) trihalomethylthio, (ix) cyano or (x) C1Ëœ4 alkylthio, R4 is (ii) 2,4-thiazolidindion-5-yl, A4 is (i) a bond, (ii) C1Ëœ4 alkylene, (iii) â€”C1Ëœ4 alkylene â€”Oâ€” or (iv) â€”C1Ëœ4 alkylene â€”Sâ€”, R7, R8 and R9 are each independently hydrogen or C1Ëœ4 alkyl, with the proviso that (1) R4 is attached to the 2- or 3-position, (2) when R4 is attached to the 3-position, A4is a bond or methylene, and Cyc1 is benzene, then A1 is methylene, ethylene or vinylene, a non-toxic salt thereof or a hydrate thereof.