Patent ID: 6686467
Filing Date: 2004-02-03
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating a disease or medical condition mediated by cytokines which comprises administering to a warm-blooded animal in need thereof an effective amount of a compound of the Formula I wherein:R1 and R2, which may be the same or different are selected from hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino, di-(C1-6alkyl)amino, carboxy, C1-6alkoxycarbonyl, carbamoyl, C1-6alkylcarbamoyl, di-C1-6alkylcarbamoyl, C1-6alkylsulphonyl, arylsulphonyl, C1-6alkylaminosulphonyl, di-(C1-6alkyl)aminosulphonyl, nitro, cyano, cyanoC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-6alkanoylamino, C1-6alkoxycarbonylamino, C1-6alkanoyl, C1-6alkanoyloxy, C1-6alkyl, halo, trifluoromethyl, aryl, arylC1-6alkyl, arylC1-6alkoxy, heteroaryl, heteroarylC1-6alkyl, heterocyclyl and heterocyclylC1-6alkyl; m and p, are independently 0-3, and when m and/or p is 2 or 3 each R group may be the same or different; R3 is C1-4alkyl; q is 0; R4 is aryl or cycloalkyl wherein R4 optionally substituted with up to 3 substituents having any value defined for R1; provided that least one of R1, R2 or at least one substituent on R4 is heteroaryl, heteroarylC1-6alkyl, heterocyclyl or heterocyclylC1-6alkyl;or a pharmaceutically-acceptable salt or in vivo cleavable ester thereof.