Patent ID: 7250551
Filing Date: 2007-07-31
Classification: A01K,A61K,C07K,C12N,C12Q,G01N

Abstract:
1. A transgenic mouse whose genome comprises a first transgene comprising a DNA sequence encoding p25 operably linked to an inducible promoter, and a second transgene comprising a DNA sequence encoding an inducer of the inducible promoter operably linked to a calcium-calmodulin-dependent kinase II promoter, exhibiting one or more features selected from the group consisting of progressive nurodegeneration, tau aggregation, neurofibrillary tangle formation, aberrant cyclin-dependent kinase 5 activity, neuronal loss in the cerebral cortex, neuronal loss in the hippocampus, severe brain atrophy, reactive astrogliosis, caspase-3 activation, upregulation of C99, upregulation of beta amyloid, tau hyperphosphorylation, amyloid precursor protein phosphorylation, amyloid precursor protein hyperphosphorylation decreased body weight, decreased forebrain body mass and a decreased brain weight.