Patent ID: 9006395
Filing Date: 2015-04-14
Classification: A61K,A61P,C07K,C12N,Y10S

Abstract:
1. A single-chain polypeptide comprising first and second domains: wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof, wherein said first domain is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and wherein said second domain comprises: (i) a clostridial neurotoxin heavy chain H (ii) a molecular clamp peptide sequence, wherein the molecular clamp peptide sequence is a polyionic peptide; wherein said second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H wherein said single chain polypeptide comprises a sequence selected from the group consisting of SEQ ID NOs: 62, 66, 116, and 120.