Patent ID: 6194406
Filing Date: 2001-02-27
Classification: C07D

Abstract:
A compound of the formula: ##STR133##whereinm is 2 or 3;n is 0 or 1;q is 1 or 2;r is 0 or 1;G.sub.1 is --CH.sub.2 -- or --C(O)--;G.sub.2 is --CH.sub.2 --, --CH(CH.sub.3)-- or --C(O)--;G.sub.3 is --CH.sub.2 -- or --C(O)--;Ar.sub.1 is a radical chosen from the group consisting of: ##STR134##whereinR.sub.1 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, hydroxy, --CF.sub.3, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.2 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;Ar.sub.2 is a radical selected from the group consisting of: ##STR135##whereinz is 1 or 2;R.sub.20 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, hydroxy, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.3 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, hydroxy, halogen, --OCF.sub.3, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, --(CH.sub.2).sub.d S(O).sub.b R.sub.22, --(CH.sub.2).sub.e CN, --O(CH.sub.2).sub.c CO.sub.2 R.sub.23, --NH.sub.2, --NHC(O)CH.sub.3, --NHSO.sub.2 CH.sub.3 wherein c is an integer from 1 to 5; b is 0, 1, or 2; d is 0 or 1; e is 0 or 1; R.sub.22 is C.sub.1 -C.sub.4 alkyl; and R.sub.23 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.21 is hydrogen or a radical chosen from the group consisting of: ##STR136##whereinf is 0 or 1;R.sub.25 is hydrogen or --CH.sub.3 ;R.sub.24 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl, --CF.sub.3, phenyl, S(O).sub.x R.sub.26, and CH.sub.2 N(CH.sub.3).sub.2 wherein x is 0, 1, or 2; R.sub.26 is C.sub.1 -C.sub.4 alkyl;R.sub.4 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, --CF.sub.3, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.5 is chosen from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl, --(CH.sub.2).sub.w --O--(CH.sub.2).sub.t CO.sub.2 R.sub.8, --(CH.sub.2).sub.j CN, --(CH.sub.2).sub.u CO.sub.2 R.sub.6, --(CH.sub.2).sub.u C(O)NR.sub.16 R.sub.17, --(CH.sub.2).sub.u C(O)CH.sub.3, --(CH.sub.2).sub.p Ar.sub.3, --(CH.sub.2).sub.w --O--R.sub.7, --CH.sub.2 CH.dbd.CHCF.sub.3, --(CH.sub.2).sub.2 CH.dbd.CH.sub.2, --CH.sub.2 CH.dbd.CH.sub.2, --CH.sub.2 CH.dbd.CHCH.sub.3, --CH.sub.2 CH.dbd.CHCH.sub.2 CH.sub.3, --CH.sub.2 CH.dbd.C(CH.sub.3).sub.2, and --(CH.sub.2).sub.g S(O).sub.k R.sub.19,whereinw is an integer from 2 to 5;t is an integer from 1 to 3;j is an integer from 1 to 5;u is an integer from 1 to 5;p is an integer from 1 to 4;g is 2 or 3;k is 0, 1, or 2;R.sub.8 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.6 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.16 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.17 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.19 is C.sub.1 -C.sub.4 alkyl or a radical of the formula: ##STR137##Ar.sub.3 is a radical chosen from the group consisting of: ##STR138##whereinR.sub.9 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, --CF.sub.3, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, and --CO.sub.2 R.sub.13 wherein R.sub.13 is chosen from the group consisting of hydrogen and C.sub.1 -C.sub.4 alkyl;R.sub.10 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;R.sub.11 is chosen from the group consisting of hydrogen, --CH.sub.3, and --CH.sub.2 OH;R.sub.12 is chosen from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl, and benzyl;R.sub.18 is chosen from the group consisting of hydrogen, halogen, --CH.sub.3, and --CH.sub.2 OH;R.sub.7 is hydrogen, C.sub.1 -C.sub.4 alkyl, --(CH.sub.2).sub.y --CF.sub.3, --CH.sub.2 CN or a radical chosen from the group consisting of: ##STR139##whereinv is an integer from 1 to 3;y is an integer from 0 to 2;R.sub.14 is chosen from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, and --CO.sub.2 R.sub.15 wherein R.sub.15 is hydrogen or C.sub.1 -C.sub.4 alkyl;provided that when G.sub.1 is --C(O)-- then G.sub.2 is either --CH.sub.2 -- or --CH(CH.sub.3)-- and G.sub.3 is --CH.sub.2 --;further provided that when G.sub.2 is --C(O)-- then G.sub.1 is --CH.sub.2 -- and G.sub.3 is --CH.sub.2 --;still further provided that when G.sub.3 is --C(O)-- then G.sub.1 is --CH.sub.2 -- and G.sub.2 is either --CH.sub.2 -- or --CH(CH.sub.3)--;or steteoisomers, or pharmaceutically acceptable salts thereof.