Patent ID: 6653097
Filing Date: 2003-11-25
Classification: A61K,C07K,C12Q,G01N

Abstract:
An isolated nucleic acid molecule, comprising a sequence of nucleotides that encodes a &bgr;2-subunit selected from a &bgr;2C-subunit, a &bgr;2D-subunit or a &bgr;2E-subunit of a human calcium channel, wherein the sequence of nucleotides encoding the &bgr;2-subunit is selected from the group consisting of:(a) a sequence of nucleotides, comprising the coding portion of the sequence of nucleotides set forth in any one of SEQ ID Nos. 26, 37 and 38; (b) a sequence of nucleotides that hybridizes under conditions of high stringency to DNA that is complementary to an mRNA transcript present in a human cell that encodes a subunit that includes the sequence of amino acids encoded by any one of SEQ ID Nos. 26, 37 and 38; (c) a sequence of nucleotides encoding a sequence of amino acids encoded by the sequence of nucleotides set forth in any one of SEQ ID Nos. 26, 37 and 38; and (d) a sequence of nucleotides degenerate with the &bgr;2-subunit-encoding sequence of (b).