Patent ID: 8956600
Filing Date: 2015-02-17
Classification: A61K,A61P,C07K

Abstract:
1. An ophthalmic drug delivery system, comprising (a) a delivery vehicle suitable for vitreous humor drug delivery consisting essentially of a phospholipid or a mixture of phospholipids selected from the group consisting of DOPC, POPC, SPC, EPC, PEG-DSPE and DOPG and cholesterol, wherein cholesterol is present in an amount of 10-33 mole percent relative to the delivery vehicle; and (b) an antagonist specific to VEGF selected from a group consisting of an antibody specific to VEGF, a VEGF receptor, a nucleic acid or a small molecule; wherein 50-90% of the antagonist is in non-associated form, the weight ratio of the phospholipid and cholesterol in combination to the antagonist is 5-80 to 1 and the life time of the antagonist is extended in the vitreous humor.