Patent ID: 6150421
Filing Date: 2000-11-21
Classification: A61K

Abstract:
A method of treating estrogen-receptor positive breast cancer in a patient afflicted with this condition, comprising administering to said patient as adjuvant therapy a therapeutically effective amount of a retinoid having the structure ##STR4## wherein the configuration at the 7-, 9-, 11- and 13-position double bonds is independently Z or E and wherein R.sub.1 is selected from the group consisting of ##STR5## wherein the keto group at the 4-position is free or protected; and ##STR6## wherein X is selected from the group consisting of hydrogen and C.sub.1-6 -alkyl and wherein Y is selected from the group consisting of hydroxy and C.sub.1-6 -alkoxyl, and wherein the absolute configuration at the 4-position is independently R or S, or a mixture of R and S.