Patent ID: 6762841
Filing Date: 2004-07-13
Classification: G01N

Abstract:
A method of performing spectral analysis in a pharmaceutical dissolution process, the method comprising:inserting a fiber optic probe of a spectral analyzer into a dissolution vessel, the dissolution vessel containing a dissolution medium, the probe having a launch cable, a return cable, a launch lens portion, a return lens portion and a reflector, the reflector being spaced from both the lens portions, the cables, lens portions and reflector being arranged and adapted to form a light pathway whereby light transmitted through the launch cable passes through the launch lens portion, through a volume of the dissolution media in the spacing between the launch lens portions and the reflector, through the return lens portion, and then through the return cable, the spacing between the reflector and the lens portions comprising a sample region, the fiber optic probe being sized and adapted to prevent bubbles in the dissolution media from being trapped in the sample region; transmitting light along the optic pathway; analyzing the transmitted light for determining certain optical properties of the dissolution media in the sample region.