Patent ID: 6080719
Filing Date: 2000-06-27
Classification: A61K,C07K

Abstract:
A cyclohexapeptide of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in whichA and B are each independently the residue of an (L) .alpha.-amino acid selected from Ala, Arg, Asp, Asn, Gin, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Tyr, and Val, andC, E, and F are each independently the residue of an (L) .alpha.-amino acid other than cysteine and tryptophan, andat least one of A, B, C, E, and F is a chemical derivative of said residue of said .alpha.-amino acid, provided that the chemical derivative is other than a residue of an (L) or (D) .alpha.-amino acid selected from Ala, Arg, Asp, Asn, Cys, GIn, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr, and Val, and provided that the cyclohexapeptide is other than cyclo-(Pro-MeTyr-Ala-MeTyr-MeTyr-D-Ala);or a physiologically tolerated salt thereof.