Patent ID: 8030464
Filing Date: 2011-10-04
Classification: C07K,C12N,C40B,G01N

Abstract:
1. An isolated nucleic acid encoding a stabilized polypeptide, wherein said stabilized polypeptide comprises a bioactive peptide and a first stabilizing group covalently linked to a terminus of said bioactive peptide, and a second stabilizing group covalently linked to the other terminus of said bioactive peptide, wherein said first stabilizing group is heterologous to the bioactive peptide and lacks the capacity to participate in the formation of an intramolecular disulfide bond within the polypeptide, and wherein said second stabilizing group is Xaa n -Pro-, Xaa n -Pro- Pro-, Pro-Xaa n or -Pro-Pro-Xaa n , wherein Xaa is any amino acid and n=1 or 2.