Patent ID: 7537782
Filing Date: 2009-05-26
Classification: A61B,A61F,A61L

Abstract:
1. A method for governing bone growth, the method comprising providing a substantially planar barrier membrane of resorbable polymer base material having a bone-growing substantially-smooth side that comprises a bone-inductive factor and a non-bone growing substantially-smooth side, the substantially planar barrier membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the bone-growing side and the non-bone growing side, the single layer of resorbable polymer base material having a substantially uniform composition, wherein a thickness of the single layer of resorbable polymer base material, measured between the bone-growing side and the non-bone growing side, is between about 10 microns and about 300 microns, wherein the single layer of resorbable polymer base material is non-porous, wherein the single layer of resorbable polymer base material consists essentially of a material selected from the group consisting of a poly-lactide polymer and a copolymer of two or more cyclic esters, and wherein the single layer of resorbable polymer base material is adapted to maintain a smooth-surfaced barrier between the bone growing side and the non-bone growing side, and is adapted to be resorbed into a mammalian body within a period of approximately 18 to 24 months from an initial implantation of the substantially planar barrier membrane of resorbable polymer base material into the mammalian body; and forming a spatial barrier with the substantially planar barrier membrane of resorbable polymer base material, the substantially planar barrier membrane of resorbable polymer base material separating a bone-growth area, which faces the bone-growing side having the bone-inductive factor, from a non-bone-growth area, which faces the non-bone growing side having a pre-implantation compositional characteristic different from a pre-implantation compositional characteristic of the bone growing side, wherein the compositional characteristic is defined by an amount or concentration of one or more of a tissue growth inhibitor or anti-tissue agent, an anti-bone agent or factor, an anti-angiogenic factor, a monoclonal or polyclonal antibody, an antibody fragment, a substance for cellular control, a chemotactic substance for influencing cell-migration, an inhibitory substance for influencing cell-migration, a mitogenic growth factor for influencing cell proliferation, a bone-inductive factor, a growth factor for influencing cell differentiation, and a factor which promotes angiogenesis.