Patent ID: 7273891
Filing Date: 2007-09-25
Classification: A61K

Abstract:
1. A process for the manufacture of stable graft reverse thermal hydrogel in which the graft reverse thermal hydrogel comprises a stable free radical graft copolymer of polyacrylic acid or neutralized polyacrylic acid and polyoxyalkylene polymer comprising: a) Providing the raw materials required for the polymerization b) Deaerating the reactant solution prior to polymerization c) Conducting a free radical polymerization with air and oxygen excluded d) Working up the reaction products with air and oxygen excluded to isolate the stable free radical graft copolymer wherein air and oxygen are excluded during synthesis from the beginning of the step of free radical polymerization until the step of working up the reaction products to produce the stable free radical graft copolymer is completed.