Patent ID: 6368589
Filing Date: 2002-04-09
Classification: A61K,C07K,C12N

Abstract:
A hybrid Bordetella gene, comprising:a Bordetella gene encoding an antigen fused at an ATG start codon to an autologous Bordetella promoter, wherein: (a) said promoter is the pertussis toxin operon (TOX) promoter and said Bordetella gene is selected from the group consisting of the filamentous hemagglutinin (FHA) and pertactin (PRN) genes, or (b) said promoter is the filamentous hemagglutinin (FHA) promoter and said Bordetella gene is selected from the group consisting of the pertussis toxin operon (TOX) and the pertactin (PRN) gene, or (c) said promoter is the pertactin (PRN) promoter and said Bordetella gene is selected from the group consisting of the pertussis toxin operon (TOX) and the filamentous hemagglutinin (FHA) gene.