Patent ID: 6136848
Filing Date: 2000-10-24
Classification: A61P,C07C,C07D

Abstract:
A flavone derivative represented by the following formula (1): ##STR70## wherein A represents a hydrogen atom, a halogen atom, a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, or a group represented by the following formula (2): ##STR71## wherein X represents a hydrogen atom or a halogen atom, and B represents --CH.dbd.CH--, --CH--N--, --N(R.sup.7)-- in which R.sup.7 represents a lower alkyl group or an alkoxyalkyl group, --O-- or --S--,W represents a single bond, --CH.sub.2 O-- or --CH.dbd.CH--,at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represents a carboxyl group, a cyano group, a substituted or unsubstituted alkyloxycarbonyl group, a tetrazolyl group, or --CONHR.sup.8 in which R.sup.8 represents a hydrogen atom, a lower alkyl group or a phenylsulfonyl group, and the remainder thereof may be the same or different and individually represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxyl group,R.sup.5 represents a hydrogen atom, a hydroxyl group, a substituted or unsubstituted lower alkoxyl group, --O(CH.sub.2).sub.m NR.sup.9 R.sup.10 in which R.sup.9 and R.sup.10 may be the same or different and individually represent a hydrogen atom or a lower alkyl group or are coupled together with the adjacent nitrogen atom to form a phthalimido group, and m stands for a number of 1-5, or a group represented by the following formula (3): ##STR72## wherein n stands for a number of 1-5, l stands for a number of 2-3, and B and X have the same meanings as defined above, andR.sup.6 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxyl group, with the proviso that a situation where A is a hydrogen atom or a halogen atom, W is a single bond and R.sup.5 is a hydrogen atom is excluded; ora salt of said flavone derivative.