Patent ID: 6770644
Filing Date: 2004-08-03
Classification: A61K,A61P,C07C,C07D

Abstract:
A hydroxamic acid derivative of the formula (I): wherein, R1 is (a) C1-8 alkyl, (b) C2-8 alkenyl, (c) C2-8 alkynyl, (o) C1-8 alkyl substituted by â€”OR2, â€”SR2, â€”NR3R4, â€”COR5 or Cyc1, (u) C1-8 alkyl substituted by â€”Oâ€”(C1-8 alkylene)â€”NR12R13â€” or â€”Sâ€”(C1-8 alkylene)â€”NR12R13, (v) C2-8 alkenyl substituted by â€”OR2, â€”SR2, â€”NR3R4, â€”COR5, Cyc1, nitrile, SO2R10, â€”Oâ€”(C1-8 alkylene)â€”OR11, â€”Oâ€”(C1-8 alkylene)â€”NR12R13 or â€”Sâ€”(C1-8 alkylene)â€”NR12R13 or (w) C2-8 alkynyl substituted by â€”OR2, â€”SR2, â€”NR3R4, â€”COR5, Cyc1, nitrile, â€”SO2R10, â€”Oâ€”(C1-8 alkylene)â€”OR11, â€”Oâ€”(C1-8 alkylene)â€”NR12R13 or â€”Sâ€”(C1-8 alkylene)â€”NR12R13, R2 is hydrogen, C1-8 alkyl, C2-9 acyl or Cyc1, R3 and R4 are each independently hydrogen, C1-8 alkyl, C2-9 acyl or Cyc1, R5 is hydroxyl, C1-8 alkyl, C1-8 alkoxy, â€”NR6R7 or Cyc1, R6 and R7 are each independently hydrogen, C1-8 alkyl or Cyc1, R10 is C1-8 alkyl or Cyc1, Cyc1 is morpholine, piperidine or piperazine; R11 is hydrogen, C1-8 alkyl, C2-9 acyl or Cyc1; R12 and R13 are each independently hydrogen, C1-8 alkyl, C2-9 acyl or Cyc1; m is an integer of 1-5; ring A is a benzene ring; ring B is a benzene ring; E is a bond, â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”; R8 is (a) C1-8 alkyl, (b) C1-8 alkoxy, (c) halogen, (d) nitro, (e) nitrile, (f) trifluoromethyl or (g) trifluoromethoxy, with the proviso that when E is a bond then, optionally, R1 and R8, taken together, is C1-4 alkylene; n is 0 or an integer of 1-5; R9 is hydrogen, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl; a nontoxic salt thereof or a prodrug thereof.