Patent ID: 6794402
Filing Date: 2004-09-21
Classification: A61P,C07D

Abstract:
Bicycle-substituted cyclohexyl amines of Formula 1 and their pharmaceutically acceptable salts thereof wherein:Ar is substituted 1 to 3 times or unsubstituted aryl wherein the substituents are selected from the groups F, Cl, Br, I, OH, NH2, SH, CN, NO2, OCH3, OC(O)CH3, CF3, OCH2CH2OH, NHC(O)CH3, NHCH3, and N(CH3)2; wherein V is â€”(CH2)nâ€”, â€”S(O)â€”, or â€”S(O)2â€”,W is â€”(CH2)nâ€”, â€”S(O)â€”, â€”S(O)2â€”, â€”Oâ€”, â€”Sâ€”, â€”Câ‰¡Câ€”, or entgegen or zusammen â€”CH(R1)&boxH;CH(R2)â€”,d is an integer from 0 to 2; n is an integer from 1 to 6; q is an integer from 0 to 6; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, OH, hydroxyalkyl, aminoalkyl, aralkyl, and N(R4)(R5) where in R4 and R5 are independently selected from hydrogen, alkyl, aralkyl, heteroaryl, heteroaralkyl, aminoalkyl, hydroxyalkyl, and thioalkyl; R is hydrogen, alkyl, C(O)R6, C(O)OR6, C(O)NHR6, -alkyl-C(O)NH2, aralkyl, (C3-C7 cycloalkyl)-alkyl, hydroxyalkyl, aminoalkyl, amino(hydroxy)alkyl, carboxyalkyl, heteroaralkyl, alkenylalkyl, or OH wherein R6 is alkyl or aralkyl; X is independently selected from hydrogen and an electron withdrawing group selected from halogen, nitro, cyano, alkyl, CF3, C(O)CH3, P(O)(Oâ€”R9)2, SO2â€”R9, SO2NHR9, C(O)NR9R9â€² wherein R9 is independently selected from C1-C6 alkyl or unsubstituted or substituted phenyl, â€”(C&boxH;NH)â€”NH2, â€”(C&boxH;NH)â€”O-alkyl, methoxymethyl, or haloalkyl, wherein the substituents may be F, Cl, Br, I, OH, NH2, SH, CN, NO2, OCH3, OC(O)CH3, CF3, OCH2CH2OH, NHC(O)CH3, NHCH3, or N(CH3)2; â€”Eâ€”Yâ€” is â€”Oâ€”C(O)â€”NHâ€”, - - - denotes a single or double bond; and * denotes cis or trans or a mixture thereof.