Patent ID: 8246979
Filing Date: 2012-08-21
Classification: A61K

Abstract:
1. A transdermal delivery system (TDS) comprising a backing layer and a self-adhesive matrix containing rotigotine, wherein the self-adhesive matrix comprises a solid or semi-solid semi-permeable polymer (1) wherein rotigotine in its free base form is incorporated, and wherein said free base has been isolated prior to its incorporation into the matrix, (2) which comprises a multitude of microreservoirs within the matrix, said microreservoirs containing rotigotine free base, (3) which is permeable to the free base of rotigotine, (4) which is substantially impermeable to the protonated form of rotigotine, and (5) wherein all the microreservoirs have a maximum diameter that is less than the thickness of the matrix; and wherein the backing layer is inert to the components of the matrix.