Patent ID: 9192594
Filing Date: 2015-11-24
Classification: A61K,A61P

Abstract:
1. A method for treating keratoconus in an eyeball of a subject in need thereof, the method comprising: applying an ophthalmic solution to the corneal epithelium of the eyeball of the subject, wherein the ophthalmic solution comprises riboflavin and D-alfa-tocopheryl polyethylene-glycol 1000 succinate (TPGS), wherein the riboflavin concentration of the ophthalmic solution is at least about 0.1% and the TPGS concentration of the ophthalmic solution is at least about 10 mg % ml, and administering UV-A rays to the eyeball of the subject, that has been treated with the ophthalmic solution, to induce collagen cross-linking in the cornea of the eyeball; and wherein the eyeball of the subject has an intact corneal epithelium.