Patent ID: 8138272
Filing Date: 2012-03-20
Classification: A61K,A61P

Abstract:
1. A process for preparing a conjugate of formula (I), wherein q is from 1 to 100; A, at each occurrence, is independently an active compound of formula (II), or a pharmaceutically acceptable salt thereof, wherein Ar J is: a) a group of formula (a), wherein or b) a group of formula (b), wherein T is a) a group of formula (c), wherein or b) a group of formula (d) wherein R and B is a group of formula Ia, which is a polymer functionalized with nucleophilic active moieties, wherein P is a polymer; q′ is greater than or equal to q, as defined in formula (I); L Nu is —N(SO provided that when X is —O— or —N(R N )—, then m is two; and provided that when R is covalently bonded to B, n is one and X is not —O—, —S—, —S(O)—, or —S(O) 2 —; comprising the steps of: a) treating, in at least one solvent, at least one active compound of formula (Ib), b) adding a polymeric nucleophile of formula (Ic),