Patent ID: 9040698
Filing Date: 2015-05-26
Classification: C07D

Abstract:
1. A method for preparing a compound represented by formula (I), including the steps: (1) in the presence of a catalyst and an oxidant, conducting an epoxidation reaction of 3,3-diphenyl acrylate represented by formula (II) to obtain (2S)-epoxy-3,3-diphenyl acrylate represented by formula (III); said catalyst is a chiral ketone derived from fructose represented by formula (IV) or a hydrate thereof represented by formula (V), and characterized in that the oxidant is selected from any one of sodium perbromate, sodium periodate, potassium monopersulfate, potassium peroxymonosulfate and hydrogen peroxide, wherein, Ph is phenyl; Ac is acetyl; R1 is selected from any one of methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl, cyclohexyl and benzyl; R is one of methyl and methoxy; (2) in the presence of an acidic catalyst and methanol, conducting an epoxy ring-opening reaction of (2S)-epoxy-3,3-diphenyl acrylate represented by formula (III) to obtain (2S)-2-hydroxyl-3-methoxy-3,3-diphenyl acrylate represented by formula (VI); wherein, Ph is phenyl; Ac is acetyl; R1 is selected from any one of methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl, cyclohexyl and benzyl; (3) in the presence of an alkaline compound, conducting a nucleophilic substitution reaction of (2S)-2-hydroxyl-3-methoxy-3,3-diphenylacrylate represented by formula (VI) and methylsulfonyl pyrimidine represented by formula (VII) to obtain a compound represented by formula (VIII); wherein, R is one of methyl and methoxy; R1 is selected from any one of methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl, cyclohexyl and benzyl; (4) in the presence of an alkaline compound, conducting a hydrolysis reaction of the compound represented by formula (VIII), then acidifying by a protonic acid, thereby obtaining the compound represented by formula (I).