Patent ID: 6291480
Filing Date: 2001-09-18
Classification: A23K,A61K,A61P,C07D

Abstract:
A compound of formula I ##STR105##or a physiologically acceptable salt thereof,whereinn is 0 or 1; m is 0, 1 or 2; p is 1 or 2 or 3; R is halogen; R.sup.1 is (1) hydrogen or (2) C.sub.1-6 alkyl; R.sup.2 is (1) C.sub.3-12 alkyl optionally substituted with 1 to 5 groups selected from R.sup.a, (2) C.sub.1-2 alkyl substituted with 1 to 3 groups selected from R.sup.a ; (3) C.sub.2-12 alkenyl optionally substituted with 1 to 5 groups selected from R.sup.a, (4) C.sub.2-12 alkynyl optionally substituted with 1 to 5 groups selected from R.sup.a, (5) C.sub.3-7 cycloalkyl-(C.sub.1-6 alkyl).sub.n, optionally substituted with 1 to 5 groups selected from R.sup.a and C.sub.1-6 alkyl, (6) aryl-(C.sub.1-6 alkyl).sub.n wherein aryl is optionally substituted with 1 to 5 groups selected from R.sup.b, (7) heteroaryl-(C.sub.1-6 alkyl).sub.n wherein heteroaryl is optionally substituted with 1 to 5 groups selected from R.sup.b, R.sup.3 is (1) O or (2) CH.sub.3 ; R.sup.a is (1) halogen, (2) N.sub.3, (3) CN, (4) NO.sub.2, or (5) P(O)(OR.sup.c).sub.2 ; R.sup.b is (1) a group selected from R.sup.a, (2) C.sub.1-6 alkyl optionally substituted with 1 to 6 groups selected from R.sup.a, OR.sup.c, OCOR.sup.c, NR.sup.c R.sup.c, NHCOR.sup.c, NHSO.sub.2 R.sup.c, (3) aryl optionally substituted with 1 to 3 groups selected from R.sup.a, OR.sup.c, OCOR.sup.c ; NR.sup.c R.sup.c c, NHCOR.sup.c, NHSO.sub.2 R.sup.c, (4) heteroaryl optionally substituted with 1 to 3 groups selected from R.sup.a, OR.sup.c, OCOR.sup.c, NR.sup.c R.sup.c c, NHCOR.sup.c, NHSO.sub.2 R.sup.c, (5) C(O)OR.sup.c, (6) C(O)R.sup.c, (7) S(O).sub.m R.sup.c, (8) OR.sup.c, (9) OC(O)NR.sup.c R.sup.c, (10) OC(O)OR.sup.c, (11) OC(O)R.sup.c, (12) OSO.sub.2 R.sup.c (13) NR.sup.c R.sup.c, (14) NR.sup.d SO.sub.2 R.sup.c, (15) NR.sup.d C(O)OR.sup.c, (16) NR.sup.d C(O)R.sup.c, (17) NR.sup.d C(O)NR.sup.c R.sup.c ; R.sup.c is (1) hydrogen, (2) C.sub.1-2 alkyl optionally substituted with 1 to 5 groups selected from halogen, (3) C.sub.2-12 alkenyl, (4) C.sub.2-12 alkynyl, (5) C.sub.3-7 cycloalkyl-(C.sub.1-6 alkyl).sub.n, (6) aryl(C.sub.1-6 alkyl).sub.n optionally substituted with NO.sub.2, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or halogen, (7) heteroaryl(C.sub.1-6 alkyl).sub.n, ortwo R.sup.c groups together with the nitrogen atom to which they are attached form a 3- to 7-membered ring optionally containing an additional heteroatom selected from O, S and N-R.sup.d ;R.sup.d is (1) hydrogen or (2) C.sub.1-6 alkyl.with the proviso that the following compounds are excluded: 2-(4-fluorophenyl)-5-(1-methyl-1-piperidinyl)-3-(4-pyridinyl)pyrrole, 2-(4-fluorophenyl)-5-(1-benzyl-4-piperidinyl)-3-(4-pyridinyl)pyrrole and 2-(4-fluorophenyl)-5-(1-phenyl-4-piperidinyl)-3-(4-pyridinyl)pyrrole.