Patent ID: 7294737
Filing Date: 2007-11-13
Classification: A61K,C07C

Abstract:
1. A process of manufacturing a compound of Formula I or its ester or salt thereof, wherein Z Z M is selected from the group consisting of hydrogen, an optionally substituted unsaturated acyl having from 1 to 18 carbon atoms, and an optionally substituted saturated acyl having from 1 to 18 carbon atoms, said optionally substituted unsaturated acyl and optionally substituted saturated acyl optionally containing a polar or charged functionality; and J is selected from the group consisting of an optionally substituted unsaturated acyl having from 1 to 18 carbon atoms and an optionally substituted saturated acyl having from 1 to 18 carbon atoms, said optionally substituted unsaturated acyl and optionally substituted saturated acyl optionally containing a polar or charged functionality; the process comprising: reacting a compound of Formula II wherein Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and Z 6 are as previously defined, with a compound of Formula III, wherein Y is R or NR 2 R 5 ; R 1 , R 2 , R 3 and R 4 and R 5 are independently selected from an optionally substituted C 1 -C 10 alkyl or an optionally substituted C R R and a compound selected from the group consisting of a saturated or unsaturated acyl halide, saturated or unsaturated carboxylic acid anhydride and a saturated or unsaturated activated carboxylic acid ester, all of which may optionally be substituted by one or more substituents selected from the group consisting of protected hydroxy, alkyl, alkenyl, acyl, nitro, protected amino, amino, halo, protected carboxy and cyano; and separating and isolating the compound of Formula I.