Patent ID: 7132437
Filing Date: 2006-11-07
Classification: C07D,H01M,H04B,Y02E

Abstract:
1. A conjugate consisting of a first radical and second radical connected together by a kidney-enzyme-cleavable amide bond, wherein said first radical is an angiotensin II antagonist compound selected from a class of compounds defined by Formula I: wherein m is a number selected from one to four, inclusive; wherein each of R wherein X is oxygen atom or sulfur atom; wherein each n is a number independently selected from zero to six, inclusive; wherein each of R and wherein each of R wherein n is a number selected from zero through three, inclusive, and wherein A is an acidic group selected to contain at least one acidic hydrogen atom, and the amide, ester and salt derivatives of said acidic moieties; wherein Y is a spacer group independently selected from one or more of alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, aralkyl; and wherein any of the foregoing R wherein X is selected from oxygen atom and sulfur atom; wherein each of R wherein D is selected from oxygen atom and sulfur atom and R wherein X is oxygen atom or sulfur atom; wherein each of R with the proviso that at least one of said R wherein said second residue is selected from a class of compounds of Formula II: wherein each of R with each of R wherein the kidney-enzyme-cleavable amide bond is a divalent radical of Formula III: wherein each of R or a tautomer thereof or a pharmaceutically-acceptable salt thereof.