Patent ID: 7247746
Filing Date: 2007-07-24
Classification: A61P,C07B,C07C

Abstract:
1. A method for the production of crystal form of nateglinide, comprising: (a) dissolving nateglinide in any of its forms in a first solvent in which nateglinide is readily soluble at an ambient temperature to form a solution, wherein the first solvent is a mixture of ethanol and toluene or a mixture of methanol and ethyl acetate; (b) treating the solution with a second solvent which is miscible with the first solvent, and in which nateglinide is only poorly soluble to induce precipitation of crystals of nateglinide, wherein the second solvent is water containing about 0.5 to about 3% by weight of hydroxypropylmethylcellulose; and (c) isolating and drying the precipitated crystal form of nateglinide.