Patent ID: 8163720
Filing Date: 2012-04-24
Classification: A61P,C07D

Abstract:
1. A method of treating or lessening the severity in a subject of acute, chronic, neuropathic, or inflammatory pain, epilepsy visceral pain, osteoarthritis pain, radicular pain, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain, comprising administering an effective amount of a compound according to formula I, or a pharmaceutically acceptable composition thereof to said subject in need thereof; wherein: ring Z is a 5 membered unsaturated or aromatic ring having 1-4 ring heteroatoms selected from O, S, or N, wherein Z is optionally substituted with up to q occurrences of R W is N and Y x and y each is independently 0-3; provided that x+y is 3; w is 0-4; v is 0 or 1; z is 0-4; V and X each is a bond; Q is a bond; R wherein R R R R n is 0, 1 or 2; or two R Y is halo, CN, NO R R R R R R Z′ is selected from halo, CN, NO R