Patent ID: 6066751
Filing Date: 2000-05-23
Classification: C07C

Abstract:
A method of preparing a compound having the structure: ##STR14## wherein R is lower alkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring;R' is hydrogen, lower alkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring provided the carbon at C.sub.15 (prostaglandin numbering) has only one heteroatom attached to it; andQ is a suitable protecting group,comprising the steps of:a) providing a compound having the structure: ##STR15## wherein R is lower alkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring;R' is hydrogen, lower alkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring provided the carbon at C.sub.15 (prostaglandin numbering) has only one heteroatom attached to it; andQ is a suitable protecting group;b) adding a hydride reducing agent to the compound provided in step a; andc) adding an epoxidizing agent to the product of step b.