Patent ID: 6528655
Filing Date: 2003-03-04
Classification: A61P,C07C,C07D

Abstract:
An hydroxyphenyl compound of formula Ia and when a compound of formula Ia comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula Ia comprises an amino group pharmaceutically acceptable ammonium salts thereof, whereinR3 represents H or â€”CH3, R5 is selected from the group consisting of H, C1 to C8 alkyl (straight or branched), HO2Câ€”(C1 to C8)alkyl (straight or branched)â€”, C6H5CH2â€”, CH3SCH2CH2â€”, H2NC(O)â€”(C1 to C8)alkyl (straight or branched)â€”, HO(C1 to C8)alkyl (straight or branched)â€”, HSCH2â€”, H2Nâ€”(C1 to C8)alkyl (straight or branched), R20O2Câ€”(C1 to C8)alkyl (straight or branched)â€”, R20HNC(O)â€”(C1 to C8)alkyl (straight or branched)â€”, R20HNâ€”(C1 to C8)alkyl (straight or branched), R20Oâ€”(C1 to C8)alkyl (straight or branched)â€”, R20SCH2â€”R20 is a predetermined protecting group substitutent R7 is selected from the group consisting of â€”NO2, â€”NH2, alkyl-Oâ€”, cycloalkyl-Oâ€”, aryl-Oâ€”, benzyloxy, â€”SH, alkyl-Sâ€”, aryl-Sâ€”, alkyl-CONHâ€”, aryl-CONH, wherein alkyl signifies an unsubstituted straight or branched alkyl group with 1 to 8 carbon atoms, cycloalkyl signifies an unsubstituted radical with 3 to 8 carbon atoms and aryl signifies an unsubstituted phenyl group, an unsubstituted benzyl group or a phenyl or benzyl group substituted by one or more of the same or different substituents selected from the group consisting of â€”OH, â€”OCH3, â€”SH, â€”SCH3, â€”NO2, â€”NH2, â€”F, â€”Cl, and â€”Br, Xâ€² represents a single bond, a saturated straight or branched hydrocarbon group of 1 to 4 carbon atoms or a straight or branched hydrocarbon group of 2 to 4 carbon atoms comprising a carbon to carbon double bond, n is 1, 2 or 3 and m is 1 or 2.