Patent ID: 7495126
Filing Date: 2009-02-24
Classification: A61P,C07C

Abstract:
1. A process for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative represented by Chemical Formula I and its pharmaceutically acceptable salt, the process is comprised of the following steps: a) oxidation of tetrafluorobenzyl alcohol, represented by Chemical Formula 1, to tetrafluorobenzaldehyde, represented by Chemical Formula 2; b) conversion of tetrafluorobenzaldehyde to tetrafluorobenzilidine-5-aminosalicylic acid derivative, represented by Chemical Formula II, via dehydration-condensation reaction between tetrafluorobenzaldehyde and 5-amino-salicylic acid, represented by Chemical Formula 3, and c) hydrogenation of tetrafluorobenzilidine-5-aminosalicylic acid derivative to tetrafluorobenzyl-5-aminosalicylic acid derivative, represented by Chemical Formula I Wherein, M