Patent ID: 6207749
Filing Date: 2001-03-27
Classification: A61K,C08G,C08J

Abstract:
A method for engineering tissue comprising growing cells on a tissue-engineering matrix formed of or coated with the cell-regulating, comb-type copolymer comprising:a) a hydrophobic polymer backbone;b) non-cell binding hydrophilic polymeric side chains grafted to the polymer backbone, wherein the side chains have a molecular weight between 200 and 2000 Daltons;wherein between zero and 100% of the non-cell binding, hydrophilic side chains are end-capped with cell-binding or cell-signaling ligands to form short cell-binding copolymer side chains andwherein the side chains comprise less than 60% of the total copolymer weight,wherein the comb copolymer is effective in regulating cellular adhesion or response to the surface.