Patent ID: 6555541
Filing Date: 2003-04-29
Classification: A61P,C07C,C07D

Abstract:
A compound of formula wherein:each R1 independently represents a hydrogen or halogen atom, or a trifluoromethyl, cyano, nitro, C1-C6 alkyl or C1-C6 alkoxy group; T represents a group NH; U represents an oxygen or sulphur atom or a group NH; Ar represents a group X represents a bond, an oxygen atom or a group CO, CH2, CH2O O(CH2)m, CH2OCH2, NR5, CH2NR5, NR5CH2, CH2NR5CH2, CONR5, S(O)n or SO2NR5; m is 1, 2 or 3; n is 0, 1 or 2; one of R2 and R3 represents a halogen, cyano, nitro, amino, hydroxyl, or a group selected from (i) C1-C6 alkyl optionally substituted by at least one C3-C6 cycloalkyl, (ii) C3-C8 cycloalkyl, (iii) C1-C6 alkyloxy optionally substituted by at least one C3-C6 cycloalkyl, (iv) C3-C8 cycloalkyloxy, (v) S(O)pC1-C6 alkyl, or (vi) S(O)qC3-C8 cycloalkyl, each of these groups being optionally substituted by one or more fluorine atoms, and the other of R2 and R3 represents a hydrogen or halogen atom or a methyl group; p is 0, 1 or 2; q is 0, 1 or 2; R4 represents a 3- to 9-membered saturated heterocyclic ring system containing one or two nitrogen atoms, the heterocyclic ring system being optionally substituted by one or more substitutents independently selected from fluorine atoms, hydroxyl, C1-C6 alkyl, acetyl, hydroxyC1-C6 alkyl, â€”NR6R7, â€”(CH2)rNR6R7, â€”CONR6R7 and pyrimidinyl; r is 1, 2, 3, 4, 5 or 6; R5 represents a hydrogen atom or a C1-C6 alkyl or C3-C8 cycloalkyl group; and R6 and R7 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C8 cycloalkyl group, or R6 and R7 together with the nitrogen atom to which they are attached to form a 3- to 8-membered saturated heterocyclic ring, provided that when R3 represents a cyano group, then X is other than a bond; or a pharmaceutically acceptable salt or solvate thereof.