Patent ID: 6482425
Filing Date: 2002-11-19
Classification: A01N,A61K,A61P

Abstract:
A method for combating parasites of a cat or dog comprising localized cutaneous application to the cat or dog, between the shoulders, at a frequency not greater than monthly, of a spot-on composition, which comprises, in a veterinarily acceptable vehicle, an amount parasitically effective of at least one compound (A), and an amount parasitically effective of at least one compound (B), wherein:compound (A) is an ectoparasiticide of the formula (I) in which:R1 is CN; R2 is S(O)nR3; R3 haloalkyl; R4 represents NH2; R11 represents halogen atom; R13 represents haloalkyl; n represents an integer equal to 0, 1 or 2; X represents a radical Câ€”R12; R12 represents a halogen atom; andcompound (B) is an endectocidal parasiticide of the macrocyclic class of compounds selected from the group consisting of avermectin, abamectin and doramectin; and, the vehicle is for a localized cutaneous application to the animal between the shoulders and contains an organic solvent, and organic cosolvent and/or a crystallization inhibitor wherein: the crystallization inhibitor selected from the group consisting of polyvinylpyrrolidone, copolymers of vinyl acetate and vinylpyrrolidone, polyoxyethylenated sorbitan esters and mixtures thereof; the organic solvent comprises acetone, ethyl acetate, methanol, ethanol, isopropanol, dimethylformamide, dichloromethane or diethylene glycol monoethyl ether; said solvent optionally supplemented by C8-C10 caprylic/capric triglyceride, oleic acid or propylene glycol or the organic solvent comprises dipropylene glycol monomethyl ether; and the organic cosolvent selected from the group consisting of ethanol, isopropanol, and methanol; whereby there is a prolonged release of compound (A) in or on the body of the cat or dog and there is a measurable plasma level of compound (B) in the cat or dog.