Patent ID: 6329523
Filing Date: 2001-12-11
Classification: C07D,C12Q,C40B,G01N

Abstract:
A compound having the formula: ##STR5##wherein:g.sup.1 is 1 to 4;g.sup.2 is 2to 4;A is an aromatic, heterocyclic, or alicyclic ring system;each x is, independently, 1 to 8;J is N, O, S, or a heterocyclic ring system having at least one nitrogen;t is 0 or 1;each T is, independently, a single bond, a methylene group or a group having the formula:--{[CR.sup.1 R.sup.2 ].sub.m --(R.sup.5)--[CR.sup.1 R.sup.2 ].sub.n --[C(R.sup.6)].sub.p --(E)--}.sub.q --each R.sup.1, R.sup.2 and R.sup.3 is, independently, H, alkyl or haloalkyl having 1 to 10 carbon atoms, alkenyl having 2 to 10 carbon atoms, alkynyl having 2 to 10 carbon atoms, or aryl having 6 to 14 carbon atoms;each R.sup.5 and E is, independently, a single bond; CH.dbd.CH; C.ident.C; O; S; NR.sup.3 ; SO.sub.2 ; C.sub.6 -C.sub.14 aryl; substituted C.sub.6 -C.sub.14 aryl; heteroaryl; substituted heteroaryl; a nitrogen, oxygen, or sulfur containing heterocycle; a substituted nitrogen, oxygen, or sulfur containing heterocycle; a mixed heterocycle; or a substituted mixed heterocycle; where said substituent groups are selected from hydroxyl (OH), alkoxy, alcohol, benzyl, phenyl, nitro (NO.sub.2), thiol (SH), thioalkoxy, halogen, alkyl, aryl, alkenyl, and alkynyl groups;each R.sup.6 is .dbd.O, .dbd.S, .dbd.NR.sup.3 ;each m and n is, independently, zero to 5;each p is, independently, zero or 1;q is 1 to 10;each L is, independently, H, C.sub.1 -C.sub.10 alkyl, substituted alkyl; C.sub.2 -C.sub.10 alkenyl; substituted alkenyl; C.sub.2 -C.sub.10 alkynyl; substituted alkynyl; C.sub.4 -C.sub.7 carbocyclic alkyl; substituted carbocyclic alkyl; alkenyl carbocyclic; substituted alkenyl carbocyclic; alkynyl carbocyclic; substituted alkynyl carbocyclic; C.sub.6 -C.sub.14 aryl; substituted C.sub.6 -C.sub.14 aryl; heteroaryl; substituted heteroaryl; a nitrogen, oxygen, or sulfur containing heterocycle; a substituted nitrogen, oxygen, or sulfur containing heterocycle; a mixed heterocycle; or a substituted mixed heterocycle; where said substituent groups are selected from alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, alcohol, benzyl, nitro, thiol, thioalkyl, thioalkoxy, trifluoromethyl or halogen groups; or L is phthalimido, an ether having 2 to 10 carbon atoms and 1 to 4 oxygen or sulfur atoms, a metal coordination group, a conjugate group, halogen, hydroxyl, thiol, keto, carboxyl, NR.sup.1 R.sup.2, CONR.sup.1, amidine (C(.dbd.NH)NR.sup.2 R.sup.3), guanidine (NHC(.dbd.NH)NR.sup.2 R.sup.3), glutamyl (R.sup.1 OOCCH(NR.sup.2 R.sup.3)(CH.sub.2).sub.2 C(.dbd.O), nitrate, nitro, nitrile, trifluoromethyl, trifluoromethoxy, NH-alkyl, N-dialkyl, O-aralkyl, S-aralkyl, NH-aralkyl, azido (N3), hydrazino (NHNH.sub.2), hydroxylamino (ONH.sub.2), sulfoxide (SO), sulfone (SO.sub.2), sulfide (S--), disulfide (S--S), silyl, a nucleosidic base, an amino acid side chain, a carbohydrate, a drug, or a group capable of hydrogen bonding;with the proviso that when A is 2,6-disubstituted pyridine with g.sup.1 equal to 2 and g.sup.2 equal to 2, and having 6 of said L groups, then not more than 3 of said L groups are H or para-toluenesulfonyl;with the further proviso that not more than one --T--L is H.