Patent ID: 6677438
Filing Date: 2004-01-13
Classification: A61K,C07K,C08G,Y10S

Abstract:
A process for attaching a polyethylene glycol (PEG) compound to a macromolecular material to prepare a conjugate or adduct between the polyethylene glycol compound and the macromolecular material which comprises the steps of:(1) preparing an activated PEG or an activated PEG derivative which includes carbon-carbon double bonds which are activated by the presence of electron withdrawing groups in the a position by incorporating an acrylic ester, an acrylic thioester or an acrylamido group into the PEG or PEG derivative; (2) reacting the activated PEG or PEG derivative with a macromolecular material comprising one or more sulphydryl groups, primary amino groups and/or secondary amino groups such that the sulphydryl groups, primary amino groups and/or secondary amino group(s) react with the carbon-carbon double bonds on the activated PEG or PEG derivative to form the conjugate or adduct; and (3) recovering the conjugate or adduct of the PEG or PEG derivative and the macromolecular material.