Patent ID: 8003402
Filing Date: 2011-08-23
Classification: G01N,Y10T

Abstract:
1. A method of cleaning a unit of manufacturing equipment used in the preparation of low molecular weight heparin (LMWH) to obtain an acceptable residual concentration of LMWH comprising: (a) subjecting the unit of manufacturing equipment to a cleaning protocol; (b) obtaining the absorbance of a sample obtained from the manufacturing equipment comprising: (c) determining the concentration of LMWH in the sample obtained from the manufacturing equipment by comparing its absorbance with the absorbances of a plurality of samples of control LMWH in aqueous solutions of known concentrations; and (d) optionally repeating steps (a)-(c) until the concentration of LMWH in the sample obtained from the manufacturing equipment is less than an acceptable residual concentration of LMWH.