Patent ID: 6818749
Filing Date: 2004-11-16
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
A humanized anti-TAG-72 CC49 antibody comprising:a light chain Complementarity Determining Region (L-CDR)1, a L-CDR2, and a L-CDR3; and a heavy chain Complementarity Determining Region (H- CDR) I, a H-CDR2, and a H-CDR3, wherein L-CDR3, H-CDR1, H-CDR2 and H-CDR3 comprise murine monoclonal CC49 antibody Complementarity Determining Regions (CDRs) and at least one of L-CDR1 and L-CDR2 are a human monoclonal LEN antibody L-CDR1 and L-CDR2, wherein the humanized CC49 antibody retains binding affinity for TAG-72 and has reduced immunogenicity, as compared to a parental humanized CC49 antibody.