Patent ID: 8247395
Filing Date: 2012-08-21
Classification: A61K,A61P,A61Q

Abstract:
1. A medicated composition for topical application comprising active ingredients consisting of fluocinolone acetonide, hydroquinone and tretinoin, the composition being an emulsion obtainable by a process comprising the steps of: (a) preparing an aqueous composition comprising water and at least one hydrophilic compound while heating at a temperature in the range of about 75° C. to about 80° C.; (b) preparing a non-aqueous composition comprising at least two hydrophobic compounds while heating at a temperature in the range of about 75° C. to about 80° C.; (c) combining the aqueous and non-aqueous compositions to form a mixture, wherein steps (a) through (c) are conducted in the absence of an emulsifier; (d) adding at least one emulsifier to the mixture comprising the aqueous and non-aqueous compositions; (e) adding tretinoin to the mixture comprising the aqueous and non-aqueous compositions; (f) adding fluocinolone acetonide to the mixture comprising the aqueous and non-aqueous compositions; (g) adding hydroquinone to the mixture comprising the aqueous and non-aqueous compositions, wherein the hydroquinone is added after adding the at least one emulsifier; and (h) homogenizing the mixture to form the emulsion.