Patent ID: 6114338
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
Heterocyclic compounds of the formula (I): ##STR161## wherein Y is single bond or C1-6 alkylene;Z is single bond, or C1-2 alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, one or two nitrogen atoms, one or two oxygen atoms or one sulfur atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, C1-4 alkyl or C1-4 alkyl substituted by a hydroxy group);Cyc is benzene, pyridine or imidazole;R.sup.1 is hydrogen atom or C1-4 alkyl;R.sup.2 is hydrogen atom, C1-4 alkyl, C1-4 alkoxy or halogen atom;R.sup.3 is hydrogen atom, C1-4 alkyl, C1-4 alkoxy or --COOR.sup.5 (in which R.sup.5 is hydrogen atom or C1-4 alkyl);with the proviso that(1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that(2) Y is not a single bond, when E is --OR.sup.4 ;or pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable salts thereof, or hydrates thereof.