Patent ID: 6436940
Filing Date: 2002-08-20
Classification: C07D

Abstract:
A dihydroindole compound of formula I wherein A and B are independently O or S;D is a methylene group optionally substituted with one or two C1-4 alkyl groups; Y is a group NR1 completing a dihydroindole ring, or a group N completing a dihydroindole ring attached via the 1-position; W is a bond, and n+m is 1, 2, 3, 4, 5, or 6; W is CO, SO, or SO2, n is 2, 3, 4, or 5 and m is 0, 1, 2, or 3, provided that n+m is not more than 6; or W is O, S, n is 2, 3, 4, or 5 and m is 0, 1, 2, or 3, provided that n+m is not more than 6, and provided that when Y is N completing a dihydroindole ring attached via the 1-position then m is 2 or 3; and when Y is NR1 completing a dihydroindole ring linked via the 2-position then m is 1, 2, or 3; R1 is selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalk(en)yl, C3-8 cycloalk(en)yl-C1-6 alk(en/yn)yl, aryl, heteroaryl, aryl-C1-6 alkyl, heteroaryl-C1-6 alkyl, acyl, thioacyl, C1-6 alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl or heteroarylsulfonyl, or R15VCOâ€” wherein V is O or S and R15 is C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-6 alkyl, aryl or heteroaryl, or a group R16R17NCOâ€” or R16R17NCSâ€” wherein R16 and R17 are independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-6 alkyl, aryl or heteroaryl, or R16 and R17 together with the N-atom to which they are linked, form a pyrrolidinyl, piperidinyl or perhydroazepin group; R2-R5 are independently selected from hydrogen, halogen, cyano, nitro, C1-6 alk(en/yn)yl, C1-6 alkoxy, C1-6 alkylthio, hydroxy, C3-8 cycloalk(en)yl, C3-8 cycloalk(en)yl-C1-6 alk(en/yn)yl, C1-6 alkylcarbonyl, phenylcarbonyl, halogen substituted phenylcarbonyl, trifluoromethyl, trifluoromethylsulfonyloxy and C16 alkylsulfonyl, one of R2-R5 alternatively being a group â€”NR13R14 wherein R13 is selected from the R1 substituents; R14 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalk(en)yl, C3-8 cycloalk(en)yl-C1-6alk(en/yn)yl, aryl, heteroaryl, aryl-C1-6 alkyl or heteroaryl-C1-6alkyl, or R13 and R14 together with the N-atom to which they are linked form a group wherein Q is C&boxH;O, C&boxH;S or CH2; T is NH, S, O or CH2; and p is 1-4 inclusive;R6-R8 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, trifluoromethyl or C1-6 alkylsulfonyl; wherein any of the aryl groups or aryl moieties is selected from the group consisting of phenyl and napthyl, and any of the heteroaryl groups or heteroaryl moieties is selected from the group consisting of indolyl, thienyl, pyrimidyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, benzofuranyl, benzothienyl, pyridyl and furanyl; or a pharmaceutically acceptable acid addition salt thereof.