Patent ID: 8323647
Filing Date: 2012-12-04
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody that selectively binds to the C-terminal part of beta-amyloid, the antibody comprising a variable light chain fragment (VL) sequence comprising the variable light chain CDR1, CDR2 and CDR3 sequences set forth in SEQ ID Nos. 1, 2 and 3, respectively, and a variable heavy chain fragment (VH) sequence comprising the variable heavy chain CDR1, CDR2 and CDR3 sequences set forth in SEQ ID Nos. 4, 5 and 6, respectively, wherein: a) position 1 of the light chain is an aspartate residue; b) position 43 of the light chain is a proline residue; c) position 46 of the light chain is an alanine residue; d) position 61 of the light chain is an arginine residue; e) position 104 of the light chain is a leucine residue; f) position 105 of the light chain is a glutamate residue; and g) position 106 of the light chain is a valine residue, according to Kabat numbering.