Patent ID: 6664047
Filing Date: 2003-12-16
Classification: C09B,C12Q,G01N,Y10S,Y10T

Abstract:
A compound having formula wherein A represents the atoms necessary to form one to two fused aromatic rings having 6 atoms in each ring selected from the group consisting of â€”Câ€”, CH or N(R2)&bgr;, provided at least one of said ring atoms is N(R2)&bgr;, wherein aromatic carbon atoms are optionally substituted one or more times by substituents selected from the group consisting of hydrogen, alkyl having from 1-6 carbons, alkoxy having from 1-6 carbons, trifluoromethyl, halogen, methylthio, â€”Lâ€”Rx and â€”Lâ€”Sc; X is selected from the group consisting of O and S, &agr; is 0 or 1 and &bgr; is 0 or 1 provided that &agr;+all &bgr;=1; R2 is selected from the group consisting of â€”Lâ€”Rx, â€”Lâ€”Sc, TAIL, BRIDGE and an alkyl group having 1-6 carbons that is optionally substituted by sulfo, carboxy, or amino; n=0, 1 or 2; Y is â€”CR3&boxH;CR4â€”; p and m=0 or 1, such that p+m=1; R3, R4, R8, and R7 are independently selected from the group consisting of hydrogen, an alkyl that is saturated or unsaturated, linear or branched, having 1-6 carbons, a halogen, a CYCLIC SUBSTITUENT, â€”OR8, â€”SR8, â€”(NR8R9), TAIL, BRIDGE, â€”Lâ€”Rx and â€”Lâ€”Sc wherein R8 and R9 are independently alkyl groups having 1-6 carbons or 1-2 alicyclic or aromatic rings; or R8 and R9 taken in combination are â€”(CH2)2â€”Wâ€”(CH2)2â€” where W is a single bond, â€”Oâ€”, â€”CH2â€”, or â€”NR10â€”, where R10 is H or an alkyl having 1-6 H carbons; or R6 and R7 taken in combination form a fused 6-membered aromatic ring wherein ring substituents R11, R12, R13, and R14 are independently selected from the group consisting of hydrogen, halogen, â€”OR8, â€”SR8, â€”(NR8R9) a CYCLIC SUBSTITUENT, TAIL, BRIDGE, â€”Lâ€”Rx, â€”Lâ€”Sc and a saturated or unsaturated alkyl having 1-6 carbons that is linear or branched; R5 is selected from the group consisting of CYCLIC SUBSTITUENT, TAIL, BRIDGE, â€”Lâ€”Rx, â€”Lâ€”Sc, a pair of electrons, sulfoalkyl and a saturated or unsaturated alkyl having 1-6 carbons that is linear or branched; R30, R31, and R32 are independently selected from the group consisting of hydrogen, alkyl having 1-6 carbons, cycloalkyl having 3-10 carbons, aryl, and heteroaryl; and, when present, BRIDGE is attached to a DYE compound provided that no more than one of R2, R3, R4, R5, R6, R7, R11, R12, R13, R14 and R15 is BRIDGE; wherein L and BRIDGE are independently a single covalent bond or a covalent linkage having 1-20 nonhydrogen atoms selected from the group consisting of C, N, O and S; Rx is a reactive group; Sc is a conjugated substance; TAIL is a heteroatom-containing moiety, DYE is a compound having formula wherein A, X, R2, &agr;, n, Ym, Yp, R5, R6, R7, R30, R31 and R32 are as defined above provided that BRIDGE not be any of R2, R3, R4, R5, R6, R7, R11, R12, R12, R13, R14 and R15.