Patent ID: 6034216
Filing Date: 2000-03-07
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound represented by structural Formula IIIa-IIIi ##STR91## where Ar.sup.1 and Ar.sup.2 are each independently selected from indolyl, ##STR92## n and o are independently 1, 2 or 3; R.sup.B, R.sup.C and R.sup.D are selected from the grouphydrogen,C.sub.1 -C.sub.6 alkyl optionally substituted with a group selected fromNR.sup.2 R.sup.3, andphenyl-C.sub.1 -C.sub.3 -NR.sup.2 R.sup.3, andhalo(F, Cl, Br, I)C.sub.1 -C.sub.6 alkyl;R.sup.1 is selected fromhydrogen,C.sub.1 -C.sub.6 alkyl,C(.dbd.O)--C.sub.1 -C.sub.6 alkyl,C(.dbd.O)--NR.sup.2 R.sup.3,C(.dbd.NR.sup.2)--NR.sup.2 R.sup.3,C(.dbd.O)O--C.sub.1 -C.sub.6 alkyl, andhalo (F, Cl, Br, I)C.sub.1 -C.sub.6 alkyl;R.sup.2 and R.sup.3 are selected fromhydrogen,C.sub.1 -C.sub.6 alkyl,piperidinyl, andhalo(F, Cl, Br, I)C.sub.1 -C.sub.6 alkyl;R.sup.2 and R.sup.3 together with the N to which they are bonded may form a 5- or 6-member heterocycle, optionally containing one additional hetero atom selected from O, S, and N where any N is optionally substituted with R.sup.1, any carbon is optionally substituted with R.sup.7 and where the heterocycle is optionally fused to a phenyl ring, optionally substituted with R.sup.4 ;R.sup.4 and R.sup.5 are independently selected from the grouphydrogenhalo (F, Cl, Br, and I),cyano,amino,amido,nitro,hydroxy,C.sub.1 -C.sub.4 perfluoroalkyl, andC.sub.1 -C.sub.3 perfluoroalkoxy;R.sup.7 is selected from the groupCOOR.sup.2,CONR.sup.2 R.sup.3,cyano,NR.sup.2 R.sup.3,NR.sup.2 COR.sup.3,azido,nitro,hydroxy,C.sub.6 -C.sub.10 aryl optionally substituted withhalo (F, Cl, Br, and I),cyano,amino,amido,nitro,hydroxy,C.sub.1 -C.sub.4 perfluoroalkyl, andC.sub.1 -C.sub.3 perfluoroalkoxy;Y is selected from the groupC.sub.1 -C.sub.6 alkyl substituted with 1-2 R.sup.7,C.sub.2 -C.sub.6 alkynyl optionally substituted with 1-2R.sup.7,C.sub.2 -C.sub.6 alkenyl optionally substituted with 1-2R.sup.7,C.sub.1 -C.sub.6 alkyloxy optionally substituted with 1-2R.sup.7, andpiperidinyl; ora pharmaceutically acceptable salt thereof.