Patent ID: 7759079
Filing Date: 2010-07-20
Classification: G01N

Abstract:
1. A method for optimizing therapy in an individual having inflammatory bowel disease (IBD) and receiving a course of therapy for the treatment of IBD, said method comprising: (a) obtaining a biological sample from said individual; (b) measuring a concentration level of at least one marker selected from the group consisting of an anti-neutrophil cytoplasmic antibody (ANCA), anti- (c) applying a logistic regression algorithm to the measured concentration level of said at least one marker to calculate an index value for said individual; (d) comparing the index value calculated from step (c) to an index value for said individual that was calculated at an earlier time during said course of therapy; and (e) determining a subsequent dose of said course of therapy for said individual based upon said comparison from step (d), wherein a higher index value calculated from step (c) indicates a need to increase the subsequent dose of said course of therapy.