Patent ID: 8901169
Filing Date: 2014-12-02
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of formula I: where: R where R 20 is selected from the group consisting of C 1-6 alkyl, —O—C 1-6 alkyl, C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 21 R 22 , —CH(R 25 )—NH 2 , —CH(R 25 )—NHC(O)O—C 1-6 alkyl, and —CH(NH 2 )CH 2 COOCH 3 ; and R 21 and R 22 are independently selected from the group consisting of H, C 1-6 alkyl, and benzyl; or R 21 and R 22 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 —O—(CH 2 ) 2 —; R 23 is selected from the group consisting of —O—C 1-6 alkyl, —O-benzyl, and —NR 21 R 22 ; R 24 is C 1-6 alkyl or C 0-6 alkylene-C 6-10 aryl; and R 25 is H, —CH 3 , —CH(CH 3 ) 2 , phenyl, or benzyl; R R X is H, —C(O)—R R R R where a is 1 and R 26 is —OH, or a is 2 and each R 26 is independently halo or —C 1-3 alkylene-OH; R 27 is —C 1-3 alkylene-OH, —C(O)NH 2 , or —SO 2 CH 3 ; b is 0, or b is 1 and R 28 is —C 1-3 alkylene-OH, or b is 2 and each R 28 is C 1-6 alkyl; R 29 is halo, —COOH, —OH, —C 1-3 alkylene-OH, —CH 2 O—CH 3 , —CONH 2 , —CN, or pyridine; R 30 is C 1-6 alkyl or C 3-7 cycloalkyl; R 31 is —OH or —C 1-3 alkylene-OH; R 32 is halo; C 1-6 alkyl; C 2-4 alkylene-O—C 1-6 alkyl; —C(O)O—C 1-6 alkyl; —C(O)N(CH 3 ) 2 ; pyridine; —SO 2 CH 3 ; —C(O)-furan; or phenyl substituted with halo, —O—C 1-6 alkyl, or —CN; and R 33 is H, —OH, —O—C 1-6 alkyl or —O—C 6-10 aryl; R R R R R R R R or a pharmaceutically acceptable salt thereof.