Patent ID: 8778396
Filing Date: 2014-07-15
Classification: A61K,A61P

Abstract:
1. An orally administrable gastroretentive pharmaceutical dosage form comprising a plurality of polymeric units, each polymeric unit comprising a cross-linked polymeric matrix which is porous and buoyant in gastric fluid, the polymeric matrix of each polymeric unit comprising: alginate, pectin, polyacrylic acid (PAA), and polymeric microparticles comprising polymers which are cross-linked and at least one pharmaceutically active ingredient, wherein at least one of the polymers is a bioadhesive polymeric adjuvant which adheres to the mucosal lining of the stomach and wherein the polymers forming the microparticles comprise chitosan and poly(methacrylate); wherein, in use, the plurality of polymeric units initially float on the surface of the gastric fluid, then release the polymeric microparticles; and further wherein the microparticles, upon release, adhere to the mucosal surface of the stomach.