Patent ID: 6080717
Filing Date: 2000-06-27
Classification: A01K,A61K,A61P,C12N

Abstract:
A method for the treatment of an individual having a need to inhibit a polypeptide, comprising administering to the individual a daily dosage of an antagonist between 0.01 mg/kg and 10 mg/kg; wherein the antagonist is a bactericidal antagonist of the polypeptide; wherein the polypeptide is selected from the group consisting of:(a) an amino acid sequence comprising SEQ ID NO:2;(b) an amino acid sequence comprising a portion of SEQ ID NO:2 which portion contains at least 50 amino acids;(c) an amino acid sequence comprising a portion of SEQ ID NO:2 which portion contains at least 30 amino acids;wherein the antagonist comprises a small molecule which binds to the polypeptide and inhibits tRNA synthetase activity of the polypeptide.