Patent ID: 8309088
Filing Date: 2012-11-13
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved, wherein the antibody or antigen-binding fragment comprises the three heavy chain CDRs (HCDR1, HCDR2and HCDR3) contained within any one of the heavy chain variable region (HCVR) sequences selected from the group consisting of SEQ ID NOs: 4, 20 and 24; and the three light chain CDRs (LCDR1, LCDR2and LCDR3) contained within any one of the light chain variable region (LCVR) sequences selected from the group consisting of SEQ ID NOs: 12, 22 and 26.