Patent ID: 6893856
Filing Date: 2005-05-17
Classification: A61P,C07K,C12N

Abstract:
1. A process for preparing a virus-inactivated plasma component, wherein the component is factor IX, factor X, or a mixture of factors IX and X, comprising the steps of: a) applying a source of the plasma component to a solid phase for extraction, the solid phase having anion exchanger materials immobilized thereon, under conditions effecting extraction by adsorption of the plasma component on the solid phase; b) applying a desorbing solution to the solid phase, the solution having an ionic strength that effects elution of the plasma component from the solid phase in a resulting eluate comprising the plasma component in the desorbing solution; followed by; c) isolation and purification of the plasma component by or d) removing solvent from the fraction to concentrate the plasma component, therein; and e) effecting virus-inactivation by treating with detergents in the presence of di- or trialkyl phosphate compounds.