Patent ID: 8399655
Filing Date: 2013-03-19
Classification: A61P,C07D,C07F

Abstract:
1. A process for producing an optically active compound of formula I or formula II: wherein: R R R R said process comprising: a) reacting a compound of formula III in the cis configuration: with a chiral acid to produce a mixture of two diastereomeric salts, wherein said chiral acid is (1R)-(−)-10-camphorsulfonic acid, (−)-2,3-dibenzoyl-L-tartaric acid, (+)-L-tartaric acid or (−)-L-malic acid; b) recovering a mixture of said two diastereomeric salts containing an excess of one of said two diastereomeric salts; c) converting said one of said two diastereomeric salts into said optically active compound of formula I or formula II.