Patent ID: 9029357
Filing Date: 2015-05-12
Classification: A61K,A61P,C07D

Abstract:
1. A combination of a compound of formula (I) and one or more therapeutic agent(s), wherein said compound of formula (I) being: wherein: X represents NR′, S or O; HetAr represents a phenyl or heteroaryl, optionally substituted with one or more substituents chosen from halogen, OR″ alkyl, cyano, NR″R′″, —COR″, —COOR″, —CONR″R′″, aryl, -alkylaryl; R represents a lower alkyl or H R′ represents H, lower alkyl, alkoxyalkyl or alkoxycarbonyl; R″, R′″ identical or different independently represent H or alkyl; HET representing a non aromatic monocyclic heterocycle containing at least one nitrogen atom, which is linked to R; B represents a single bond or an -alkyl- group; A represents O, NH or S; Ar is a mono or polycyclic aromatic or a mono or polycyclic heteroaromatic which can be optionally substituted with one or more of: halo; azido; cyano; hydroxy; nitro; alkyl; alkoxy; alkylsulfanyl; alkenyl; alkynyl; alkenyloxy; alkenyloxy; alkenylsulfanyl; alkynylsulfanyl; cycloalkoxy; cyloalkylalkyl; amino; alkylamino; alkylcarbonyl; alkoxycarbonyl; alkylsulfanyl; alkylsulfinyl; alkylsulfonyl; alkylsulfonyloxy whose alkyl can be substituted with one or more of halo; aminocarbonyl which can be N-substituted with one or two of alkyl, aryl, arylalkyl; aryl; arylalkyl; aryloxy; arylalkoxy; arylalkylamino; arylalkylsulfanyl; heteroaryl; heteroaryloxy heterocyclyl; heterocyclyloxy; heterocyclylalkoxy or fused with a non aromatic heterocycle (optionally substituted with one or more of halogens) or carbocycle; as well as their enantiomers, diastereomers, mixtures thereof and pharmaceutically acceptable salts, tautomers, hydrates and solvates; and wherein said one or more therapeutic agent(s) selected from the group consisting of: Histamine H Leukotriene antagonists, 5-Lipoxygenase (5-LO) inhibitors or 5-lipoxygenase activating protein (FLAP) antagonists CX Xanthines, such as theophylline and aminophylline, Steroidal and non-steroidal antiinflammatories, such as sodium cromoglycate and nedocromil sodium, Ketotifen, COX-1 inhibitors (NSAIDs) and COX-2 selective inhibitors, Immunosuppressants, and mucolytics or anti-tussive agents.