Patent ID: 7939629
Filing Date: 2011-05-10
Classification: C07K

Abstract:
1. A peptide-resin conjugate A-W, wherein A=P-X1-Asp(R4)-Phe-Glu(R5)-Glu(R6)-Ile-Pro-Glu(R7)-Glu(R8)-Tyr(R9)-X2 (SEQ ID NO:3), wherein X1 is a peptidyl moiety of 0 to 200 amino acids, X1 optionally comprising protection groups on individual amino acid side chains, wherein R9 is an amino side chain protection group and wherein X2 is a single amino acid residue linked to the solid phase via —O— and optionally being side chain or C-terminally protected, and wherein P is H or is a protection group selected from the group consisting of Boc, Fmoc, Dde, Nps, Alloc, Z, and R4, R5, R6, R7 and R8 are amino acid side chain protection groups, and wherein W is a solid phase composite comprising a resin handle or linker a) of the formula II with the proviso that then A, where including a residue X2, is always linked via —O— to said handle or linker, and wherein R′″ is a solid phase, and wherein R″ b) or of the formula III with the proviso that then A, where including a residue X2, is linked via —O— to said handle or linker, R′″ being defined as above, c) or of the formula IV wherein R′″ is defined as above and R″ and wherein W allows of cleaving the peptide moiety under weakly acidic conditions of 0.1% to 30% trifluoroacetic acid.