Patent ID: 6756489
Filing Date: 2004-06-29
Classification: A61P,C07H

Abstract:
A compound of the formula II, where formula II is chosen from formula IIa, IIb, and IIc: and whereinR1 is a group of the formula III (C1-C6)-alkylene-[Nâ€”C(O)]nâ€”[(C6-C12)-arylene]pâ€”(C0-C6)-alkylene-C(O)R9â€ƒâ€ƒ(III) â€ƒin which n and p are 0 or 1, where p and n cannot simultaneously be 1; R2 in the case in which X is equal to O, is acetyl or banzoyl; in the case in which X is equal to N is a phthaloyl protective group, DDE (1-(4,4-dimethyl-2,6-dioxocyclohexylideneethyl) or NDE (2-acetyl-4-nitroindan-1,3-dione); R3 is an allyl protective group; R4 is ethoxy or SEM (2-(trimethylsilyl)ethoxymethyl); R5 is tert-butyidimethylsilyl or tert-butyldiphenylsilyl; R9 is OR10 or NR11R11, where R10 is H, (C1-C6)-alkyl, (C1-C6)-alkyl-(C6-C12)-aryl, and R11 independently of one another is H, (C1-C6)-alkyl, (C1-C6)-alkyl-(C6-C12)-aryl or a polymeric solid support; Y is O or S; and X is O or N.