Patent ID: 8697409
Filing Date: 2014-04-15
Classification: C12N,C12P,C12Y

Abstract:
1. A ketoreductase mutant that differs from a non-mutant ketoreductase in amino acid sequence by 1-5 residues, wherein the non-mutant ketoreductase comprises the amino acid sequence of SEQ ID NO: 1, or comprises a polypeptide having an amino acid sequence at least 90% identical to SEQ ID NO: 1, wherein the differing 1-5 residues in said mutant are selected from the group consisting of the residues in said mutant that are located at positions which correspond to positions 42, 149, 153, 270 and 306 of SEQ ID NO: 1, and wherein the amino acids at said differing 1-5 residues in said mutant are different from the amino acids located at the corresponding positions in SEQ ID NO: 1.