Patent ID: 9138509
Filing Date: 2015-09-22
Classification: A61L,A61P

Abstract:
1. A composition for application to a bone defect site, the composition consisting of demineralized or partially demineralized osteoinductive bone particles, a carrier, and optionally, one or more of (i) one or more growth factor additives, (ii) a cellular material taken from the group consisting of living cells and cell elements, (iii) one or more antiviral additives effective against HIV and hepatitis, and (iv) an antimicrobial and/or antibiotic selected from the group consisting of one or more of erythromycin, bacitracin, triclosan, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin, streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin, and gentamycin; wherein the bone particles range from about 100 to 850 microns in size, and are present in an amount ranging from about 38% to about 42% (w/w) of the composition; and wherein the carrier consists of carboxymethylcellulose and sodium hyaluronate in one or more of a phosphate buffered aqueous solution, saline, or sterile water, wherein the carboxymethylcellulose and sodium hyaluronate are present in a weight ratio of about 20:1, and wherein the carboxymethylcellulose has a molecular weight in a range of from about 200,000 to about 500,000 Daltons.