Patent ID: 8119391
Filing Date: 2012-02-21
Classification: B01L,G01N

Abstract:
1. A diagnostic system having a biochip readout apparatus, comprising: a biochip readout device including: a biochip cartridge comprising: (i) an optical disc comprising a first and a second substrate and a selective wavelength reflection film disposed on the first substrate, the first substrate having one or more substantially circular lands and grooves formed thereon, the second substrate having one or more depressed portions formed therein; and (ii) at least one or more preformed biochips each comprising bio-cells spotted on the second substrate and forming an array having a substantially square or rectangular shape; wherein the at least one or more biochips are removably installed in each of the depressed portions such that the at least one or more biochips cannot be separated from the optical disc when the optical disc is rotated or moved or the biochip is combined with another substrate thereon; and the selective wavelength reflection film is disposed between the one or more biochips and the first substrate; a disc rotation drive unit driven such that the biochip cartridge is rotated; a system and output controlling unit for outputting monitoring bio analysis information, the system and output controlling unit having a signal processing unit for processing and analyzing the bio analysis signal corresponding to bio analysis information to generate the monitoring analysis information; an optical pick-up device comprising: a light receiving unit comprising one or more light sources and one or more light detectors wherein the one or more light detectors is a photomultiplier tube or photodiode; wherein light from the one or more light sources is reflected by the reflective coating of the selective wavelength reflection film of the biochip cartridge and is detected by the one or more light detectors to obtain tracking and focusing signals for the optical pick-up device; and light from the one or more light sources causes the one or more biochips to emit a fluorescent signal that is detected by the one or more light detectors; a focusing/tracking controlling unit for controlling a focusing and tracking operation of the optical pick-up device using the tracking and focusing signals from the first light detector, so that the light from the one or more light sources tracks along the one or more lands and grooves of the biochip cartridge; an objective lens driving unit for focusing the light from the one or more light sources; a bio analysis signal generation unit for receiving the fluorescent signal emitted by the one or more biochips and outputting a bio analysis signal; and an optical recording/reproducing unit for recording a recording bio analysis signal in a predetermined area of the biochip cartridge in response to a control signal of the system and output controlling unit and reproducing recorded biochip analysis information; a mode selection unit for selecting one of a biochip readout mode and a general optical recording/reproducing mode; and a diagnosis device for comparing the monitoring bio information for monitoring image signal from the biochip readout device with reference data and proving an analysis result generated based on a result of the comparing operation to a user, wherein the reference data for monitoring bio-information of the biochip are constructed in database format in the diagnosis device.