Patent ID: 8569265
Filing Date: 2013-10-29
Classification: A61K,A61P,C07B,C07F

Abstract:
1. A deuterated analog of (4S)-4-Ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (also known as 7-[2-trimethylsilyl)ethyl]-20(S)-camptothecin; BNP1350; and Karenitecin), BNP10120 (4S)-12,12-Dideutero-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; wherein BNP10120 consists of the chemical structure illustrated below: and pharmaceutically-acceptable salts thereof.