Patent ID: 6716825
Filing Date: 2004-04-06
Classification: A61K,A61P,C07F,C07H

Abstract:
A phosphonate compound having the structure: wherein:R1 and R1â€² are independently â€”H, optionally substituted â€”O(C1-C24)alkyl, â€”O(C1-C24)alkenyl, â€”O(C1-C24)acyl, â€”S(C1-C24)alkyl, â€”S(C1-C24)alkenyl, or â€”S(C1-C24)acyl, wherein at least one of R1 and R1â€² are not â€”H, and wherein said alkenyl or acyl optionally have 1 to about 6 double bonds, R2 and R2â€² are independently â€”H, optionally substituted â€”O(C1-C7)alkyl, â€”O(C1-C7)alkenyl, â€”S(C1-C7)alkyl, â€”S(C1-C7)alkenyl, â€”O(C1-C7)acyl, â€”S(C1-C7)acyl, â€”N(C1-C7)acyl, â€”NH(C1-C7)alkyl, â€”N((C1-C7)alkyl)2, oxo, halogen, â€”NH2, â€”OH, or â€”SH; R3 is a phosphonate derivative of a pharmacologically active compound linked to a functional group on optional linker L or to an available oxygen atom on C&agr;; X, when present, is: L is a valence bond or a bifunctional linking molecule of the formula â€”Jâ€”(CR2)tâ€”Gâ€”, wherein t is an integer from 1 to 24, J and G are independently â€”Oâ€”, â€”Sâ€”, â€”C(O)Oâ€”, or â€”NHâ€”, and R is â€”H, substituted or unsubstituted alkyl, or alkenyl; m is an integer from 0 to 6; and n is 0 or 1.