Patent ID: 6589965
Filing Date: 2003-07-08
Classification: A61K,A61P

Abstract:
A method of preventing the occurrence of migraine headaches and symptoms associated with migraine headaches in a person susceptible to said migraine headaches comprising the step of administering to said person a pharmacologically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein n is 2; R1 and R2 are independently H, provided that both are not H, â€”OH, CN, CH2CN, 2- or 4-CF3, CH2CF3, CH2CHF2, CH&boxH;CF2, (CH2)2CF3, ethenyl, 2-propenyl, OSO2CH3, OSO2CF3, SSO2CF3, COR, COOR, CON(R)2, CONH2, SOxCH3, SOxCF3, O(CH2)xCF3, where x is 0-2, SO2N(R)2, CH&boxH;NOR, COCOOR, COCOON(R)2, C1-8 alkyl, C3-8 cycloalkyl, CH2OR, NO2, halogen, thienyl, furyl, pyrrole, oxazole, thiazole, N-pyrroline, triazole, tetrazole or pyridine; R3 is hydrogen, CF3, CH2CF3, C1-8 alkyl, C3-8 cycloalkyl, C4-9 cycloalkyl-methyl, C2-8 alkenyl, C2-8 alkynyl, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, â€”(CH2)mâ€”R5, where m is 1-8, CH2SCH3 or a C4-8 alkyl bonded to the N-atom and one of its adjacent carbon atoms to form a heterocyclic structure; R4 and R are independently selected from hydrogen, CF3, CH2CF3, C1-C8 alkyl, C3-8 cycloalkyl, C4-9 cycloalkyl-methyl, C2-8 alkenyl, C2-8 alkynyl, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or â€”(CH2)mâ€”R5, where m is 1-8; R5 is phenyl, phenyl substituted with CN, CF3, CH2CF3, C1-8 alkyl, C3-8 cycloalkyl, C4-9 cycloalkyl-methyl, C2-8 alkenyl or C2-8 alkynyl, 2-thiophenyl, 3-thiophenyl, â€”NR6CONR6R7 or CONR6R7; and R6 and R7 are independently hydrogen, C1-8 alkyl, C3-8 cycloalkyl, C4-9 cycloalkyl-methyl, C2-8 alkenyl or C2-8 alkynyl.