Patent ID: 6660738
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of compounds of formula I whereinR1 is hydrogen, alkylcarbonyl or arylcarbonyl; R2 is alkyl, alkinyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonyl, alkylcarbonylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, alkylsulfonyl, aryl, arylalkyl, arylalkoxyalkyl, aryl(alkoxycarbonyl)alkyl, arylaminocarbonyl, diarylalkyl, aryl(carboxyalkyl)aminocarbonyl, arylcarbonyl, arylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclylalkyl or the group YR2 is heterocyclyl; R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, alkylcycloalkyl, alkylcycloalkylalkyl, alkylthio, cycloalkyl, cycloalkylalkyl, carbamoyl, carboxy, carboxyalkyl, cyano, amino, mono- and dialkylamino, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkenyl, alkinyl, aryl, arylalkyl, arylalkyl(alkoxycarbonyl)alkyl, arylcarbonylalkyl, arylalkenyl, aryl(alkoxycarbonyl)alkyl, arylamino, arylalkylamino, aryloxy, halogen, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, trimethylsilanylethynyl or trifluormethyl; R5 is hydrogen, alkyl, aryl, arylalkyloxycarbonyl, or alkylcarbonyl; X1, X2, X3 and X4 are CH or N with the proviso that only up to two of X1, X2, X3 and X4 are N; and Y is â€”Oâ€” or â€”NR5â€”; pharmaceutically acceptable esters and pharmaceutically acceptable salts thereof.