Patent ID: 9095537
Filing Date: 2015-08-04
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A kit of parts comprising compounds for antitumor therapy in a host, wherein said compounds comprise: (i) a recombinant adenylate cyclase (CyaA) protein or fragment thereof, the CyaA protein or fragment thereof comprising at least one inserted polypeptide bearing at least one epitope of a tumor-associated antigen, wherein the CyaA protein or fragment thereof retains the ability to target the CD11b/CD18 receptor on Antigen Presenting Cells; and (ii) a toll-like receptor (TLR) agonist selected from a TLR-9 agonist, a TLR-3 agonist, and a TLR-7 agonist, wherein the recombinant adenylate cyclase (CyaA) protein or fragment thereof, and the TLR agonist are in amounts sufficient to reduce the growth of a tumor in the host.