Patent ID: 8258331
Filing Date: 2012-09-04
Classification: C07F

Abstract:
1. A method for preparation of N-methyl-3-(2-tributylstannylphenoxy)-3-phenylpropanamine (MSPP), comprising: (1) dehydrating initial reactants 3-chloro-1-phenylpropanol and 2-halophenol, to generate phenylpropane halide; (2) heating at least one compound of (1) and excessive aqueous methylamine solution to reflux, to generate N-methyl-3-(2-halophenoxy)-3-phenylpropanamine; and (3) subjecting at least one compound of (2) and bis(tributyltin) to a substitution reaction, to generate N-methyl-3-(2-tributylstannylphenoxy)-3-phenylpropanamine.