Patent ID: 6500846
Filing Date: 2002-12-31
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (1): In whichR1, R3, and R4 each independently represent hydrogen, halogen, hydroxy, alkyl, lower alkoxy, amino or nitro, R2 represents â€ƒwherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two subsituents selected from the group consisting of halogen, cyano, nitro and amino; or 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino,isooxazolyl, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents SO2, B represents hydrogen or alkyl, R5 represents hydrogen or hydroxy, and R6 and R7 are substituted at o-, m- or p-position from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy, or a pharmaceutically acceptable salt, hydrate, solvate and isomer thereof.