Patent ID: 6255288
Filing Date: 2001-07-03
Classification: A61K,A61P

Abstract:
A method of treating fractures in mammals, which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound of formula I ##STR4##wherein(a) R.sub.1 and R.sub.2 are each independently of the other halogen or(b) R.sub.1 is hydrogen and R.sub.2 is a group Ar--S--, Het.sub.1 --NH--, Cyc--NH--, Ar--S--A--N(R')--, Het.sub.3 --S--A--N(R')-- or is N-phenylthiocarbamoyl, wherein Ar is unsubstituted or substituted phenyl, Het.sub.1 and Het.sub.3 are each unsubstituted or substituted monocyclic 5- or 6-membered monoaza-, diaza- or thiaza-aryl which is bound through a ring carbon atom, Cyc is cycloalkyl, A is alkylene and R' is hydrogen or lower alkyl, or(c) R.sub.1 is hydrogen or hydroxy and R.sub.2 is --A--R.sub.3, wherein A is alkylene, andR.sub.3 is either Ar as defined above or is Het.sub.2, which has the meaning of Het.sub.1 but can be bound through a ring carbon atom or a ring nitrogen atom, orR.sub.3 is unsubstituted or substituted bicyclic monoaza-, diaza- or triaza-aryl which is bound through a ring carbon atom or a ring nitrogen atom, orR.sub.3 is unsubstituted amino or amino which is mono- or disubstituted by alkyl, cycloalkyl, Ar-alkyl, Ar--O-alkyl, Ar--S-alkyl or Het.sub.1 -alkyl each independently of one another, and Ar and Het.sub.1 are as defined above, orR.sub.3 is unsubstituted or Ar-substituted alkyleneamino, wherein two alkylene carbon atoms may be additionally linked to each other through alkylene, and Ar is as defined above,or of the methanebisphosphonic acid esters 5-benzoyl-3,4-dihydro-2H-pyrazole-3,3-diphosphonic acid tetraethyl ester or 1-(4-phenylthiobutylamino)methane-1,1-diphosphonic acid tetraethyl ester,or a pharmaceutically acceptable salt thereof, or any hydrate thereof.