Patent ID: 8399457
Filing Date: 2013-03-19
Classification: A61P,C07D

Abstract:
1. Nonane and decane diazabicyclic compounds having homopiperazine as main ring, having affinity for the opioidergic μ and/or δ and/or κ receptors and/or for all their receptorial subclasses, with central and/or peripheral activity, having formula (I), the isomeric forms and their mixtures included, wherein one or more ring atoms are optionally in the corresponding isotopic forms: wherein: n is an integer equal to 1 or 2; one of the substituents R and R the other substituent is selected from the following: wherein: R B is a group selected from the group consisting of: hydrogen, isothiocyanate, CN, OR′, C(O)OR′, C(O)R′, C(O)NR′R″, and NR′R″, wherein R′ and R″, equal to or different from each other, are selected from hydrogen, linear or branched when possible C D and R (III): wherein: B′ is the same as B, R R when B′ and R (IV): wherein: B″ has the same meaning as B′, R R (V): wherein: R B (VI): wherein: R B D (VII): wherein: D wherein DV has the meanings of R 4 as defined above but excluding aryl or heteroaryl; wherein R wherein R