Patent ID: 8309120
Filing Date: 2012-11-13
Classification: A61K,A61P

Abstract:
1. A transdermal therapeutic system for administering in varying sizes of doses a lipophilic, poorly water-soluble and sparingly skin-permeable active substance, wherein the active substance possesses a solubility in water of less than 0.3%-wt. and is present in a form selected from the group consisting of a dissolved form and a suspended form in a multi-component enhancer system for forming an active substance-containing preparation, said enhancer system consisting of 4 enhancer-components and each component of said multi-component enhancer system being selected from a different one of the substance groups: a) terpenes; b) cyclic glucitol ethers; c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms; wherein said terpenes are eucalyptol; wherein said cyclic glucitol ethers are dimethyl isosorbide, and wherein said longer-chain alcohols having a chain length of 8 or more carbon atoms are 1-dodecanol.