Patent ID: 9180166
Filing Date: 2015-11-10
Classification: A61K,A61L,A61P,C08L,C12N,D01D,D01F

Abstract:
1. A composite hydrogel composition for facilitating cell growth or differentiation in cartilage comprising from 1% to 10% by weight of a water soluble anionic cellulose, and from 1% to 10% by weight of a polycationic polysaccharide, wherein the anionic water soluble cellulose forms a hydrogel, and wherein the polycationic polysaccharide forms a self-assembled fiber or filament network on the cellulose hydrogel, wherein the composition mimics the natural extracellular matrix of cartilage; and a mesenchymal stem cell (MSC) contained in or on the hydrogel, wherein the composition facilitates cell growth or differentiation of the MSC, wherein the water soluble anionic cellulose is sodium cellulose sulfate having from about 18% to about 20% sulfation.