Patent ID: 8372802
Filing Date: 2013-02-12
Classification: A61K,A61P,C07K

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of: (i) —C (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) hydrogen; deuterium; A is absent or selected from —(C═O)—, —S(O) wherein R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C L substituted —C —C M is absent or selected from O, S, SO, SO L substituted —C —C Z G is selected from —OH, —NH(SO R (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl; substituted heterocycloalkyl; (iii) —C R (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C alternatively, R Q X is absent or is selected from the group consisting of: (1) oxygen; (2) sulfur; (3) NR (4) —O—NH—; Y is absent or is selected from the group consisting of: (i) —C(═O)—, —C(═O)—NH—, —S(O) (ii) —C (iii) —C (iv) —C (v) —C W is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, and substituted heterocycloalkyl; each of which is optionally fused with one or more aryl, substituted aryl, heteroaryl; substituted heteroaryl, cycloalkyl, substituted cycloalkyl, or heterocycloalkyl; provided that when X is oxygen and Y is absent, W is not quinoxaline; m is 0, 1, 2 or 3; m′ is 0, 1, 2 or 3; and s is 1, 2, 3 or 4.