Patent ID: 7048924
Filing Date: 2006-05-23
Classification: A61K,A61P,Y10S

Abstract:
1. A method of promoting immunologic control of human immunodeficiency virus (HIV) in an HIV-infected subject, said method comprising administering to said subject highly active antiretroviral therapy (HAART) for at least one cycle of an intermittent dosing regimen in combination with intermittent administration of a pharmaceutical composition comprising a therapeutically effective amount of interleukin-2 (IL-2) or a therapeutically effective amount of a variant thereof throughout each cycle of said intermittent dosing regimen of HAART, said variant thereof having at least 90% amino acid sequence identity to said IL-2, wherein said intermittent administration comprises a dosing regimen selected from the group consisting of: a) subcutaneous administration of an intermediate dose of said IL-2 or variant thereof for 5 days, once every four weeks; b) subcutaneous administration of an intermediate dose of said IL-2 or variant thereof for 5 days, once every 6 weeks; and c) subcutaneous administration of an intermediate dose of said IL-2 or variant thereof for 5 days, once every 8 weeks.