Patent ID: 7011815
Filing Date: 2006-03-14
Classification: A61B,A61K,C07F

Abstract:
1. A method of MR imaging of a mammal, said method comprising the steps of: (a) administering to said mammal a contrast agent or a pharmaceutically acceptable salt thereof, said contrast agent having the formula: wherein m, s, o, p, and q are one; wherein said IEM is an image enhancing moiety selected from the group consisting of: wherein one of R wherein R wherein R wherein said M is a paramagnetic metal ion selected from the group consisting of Gd(III), Fe(III), Mn(II), Mn(III), Cr(III), Cu(II), Dy(III), Tb(III), Ho(III), Er(III), and Eu(III); wherein said L is a linker consisting of 1 to 4 —CH wherein said BHEM is a phosphodiester moiety; and wherein said PPBM is an HSA binding moiety; and (b) subjecting said mammal to MR imaging.