Patent ID: 6333402
Filing Date: 2001-12-25
Classification: A61K,A61P,C07K

Abstract:
A synthetic polynucleotide encoding a kallikrein binding protein of 56-60 amino acids comprising a non-naturally occurring Kunitz domain, said polynucleotide encoding:amino acid number 5 as Cys;amino acid number 13 selected from His and Pro;amino acid number 14 as Cys;amino acid number 16 selected from Ala and Gly;amino acid number 17 selected from Ala, Asn, and Ser;amino acid number 18 selected from His and Leu;amino acid number 19 selected from Gln, Leu, and Pro;amino acid number 30 as Cys;amino acid number 38 as Cys;amino acid number 51 as Cys; andamino acid number 55 as Cys;wherein the above amino acids are numbered to correspond to the numbering of amino acid residues of bovine pancreatic trypsin inhibitor (BPTI) (SEQ ID NO:1).