Patent ID: 6117910
Filing Date: 2000-09-12
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: ##STR13## wherein: Q is --O(CH.sub.2).sub.m --, --NHC(O)CH.sub.2 --, or --C(O)NHCH.sub.2 --;R* is H, Q--CO.sub.2 R', CO.sub.2 R', C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, hydroxy, halo, NR'R', CN, CONR'R', CF.sub.3 or ARC.sub.0-4 alkyl;R.sup.6 is W--(CR'.sub.2).sub.q --Z--(CR'R.sup.7).sub.r --U--(CR'.sub.2).sub.s --V--;Z is (CH.sub.2).sub.t, Het, Ar or C.sub.3-7 cycloalkyl;W is R'.sub.2 N, H.sub.2 NC(.dbd.NH), H.sub.2 NC(.dbd.NH)NH or .sup.N ;U and V are absent or CO, CR'.sub.2, C(.dbd.CR'.sub.2), S(O).sub.n, O, NR', CR'OR', CR'(OR"")CR'.sub.2, CR'.sub.2 CR'(OR""), C(O)CR'.sub.2, CR'.sub.2 C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O).sub.n NR', NR'S(O).sub.n, N.dbd.N, NR'NR', NR'CR'.sub.2, NR'CR'.sub.2, CR'.sub.2, OCR'.sub.2, or CR'.dbd.CR', provided that U and V are not simultaneously absent;R.sup.7 is H, C.sub.1-4 alkyl or --NR'R"";R' is H, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl or Ar--C.sub.0-4 alkyl;R"" is R', --C(O)R' or --C(O)OR.sup.10 ;R.sup.10 is H, C.sub.1-6 alkyl or Ar--C.sub.0-4 alkyl;m is 1 or 2;n is 0 to 3;q is 0 to 3;r is 0 to 2;s is 0 to 2; andt is 0 to 2;or a pharmaceutically acceptable salt thereof.