Patent ID: 8790645
Filing Date: 2014-07-29
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A bispecific single chain antibody construct, whereby said construct comprises at least two domains, whereby one of said domains binds to human EpCAM antigen and a second domain binds to human CD3 antigen, wherein said binding domain specific for EpCAM comprises at least one CDR-H3 region comprising the amino acid sequence NXD preferably in position 102 to 104 of SEQ ID NOs: 80, 88 and 96, or preferably in position 106 to 108 of SEQ ID NOS: 84 and 92, wherein X is an aromatic amino acid and wherein the V (a) an amino acid sequence as shown in any of SEQ ID NO: 80, SEQ ID NO: 84, SEQ ID NO: 88, SEQ ID NO: 92 and SEQ ID NO: 96; (b) an amino acid sequence encoded by a nucleic acid sequence as shown in SEQ ID NO: 79, SEQ ID NO: 83, SEQ ID NO: 87, SEQ ID NO: 91 and SEQ ID NO: 95; and (c) an amino acid sequence encoded by a nucleic acid sequence which is degenerate as a result of the genetic code to a nucleotide sequence of (b); and wherein the V