Patent ID: 6515180
Filing Date: 2003-02-04
Classification: B01J,C07C,C07D

Abstract:
A process for preparing compounds of the formula (I) in whichR1, R2 and R3 independently of one another are H, A, Ar, â€”Si(R6)3, â€”Sn(R6)3, â€”SR7, â€”OR7, â€”NR8R9, R4 is A, Ar, â€”Si(R6)3, â€”Sn(R6)3, â€”SR7, â€”OR7, â€”NR8R9, in which R8, R9 and R10 are as defined above, with the proviso that when R4 is A, R4 may not have more than one hydrogen in the &bgr; position,R6, R7, R8 and R9 independently of one another are A or Ar, A is a straight-chain or branched alkyl radical having from 1 to 10 C atoms, a straight-chain or branched alkenyl radical having 2 to 10 C atoms, or a straight-chain or branched alkynyl radical having 2-10 C atoms or a substituted or unsubstituted cycloalkyl radical having 3-8 C atoms, or a mono- or polyunsaturated cycloalkyl radical having 3-8 C atoms, and Ar is a substituted or unsubstituted aryl radical having 6-20 C atoms, wherein a compound of the general formula (II) â€ƒin which R1, R2 and R3 have the meanings given above for the formula (I) is reacted with a nucleophilic reagent of the general formula (IIIa) or a nucleophilic reagent of the general formula (IIIb) Zâ€”R4â€ƒâ€ƒ(IIIa) Zâ€”R4â€”R4â€”Zâ€ƒâ€ƒ(IIIb) â€ƒin which R4 has the meaning given for the formula (I), and Z is Li or MgX where X is Hal and Hal is Cl, Br or I, wherein the process is carried out in the presence of catalytic amounts of a metal alkoxide selected from the group consisting of titanium alkoxide, zirconium alkoxide and hafnium alkoxide, and wherein the process is carried out in the presence of a cocatalyst.