Patent ID: 8986736
Filing Date: 2015-03-24
Classification: A61K,A61P

Abstract:
1. A method for delivering a pharmaceutical composition to a tissue target of a mammalian subject, the method comprising the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns; and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain: wherein the particles comprise a compound having a solubility in water of less than about 10 mg/mL selected from the group consisting of a protease inhibitor, a nucleoside reverse transcriptase inhibitor, and a non-nucleoside reverse transcriptase inhibitor; and wherein the mammalian subject has HIV infection in the brain.