Patent ID: 6037354
Filing Date: 2000-03-14
Classification: C07D

Abstract:
A compound of the formula: ##STR160## wherein Q is selected from ##STR161## E, G, L and M are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.6, (CH.sub.2).sub.0-4 N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6 or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2 ;J is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.6, (CH.sub.2).sub.1-4 N(R.sup.19).sub.2, (CH.sub.2).sub.1-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2 ;R.sup.1 is selected from unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, CF.sub.3, cyano, nitro, OR.sup.6, N(R.sup.19).sub.2, NR.sup.19 COR.sup.20, NR.sup.19 CON(R.sup.20).sub.2, NR.sup.19 SO.sub.2 R.sup.6, NR.sup.19 SO.sub.2 N(R.sup.20).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6 or C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, pyridyl N-oxide (N.fwdarw.O), pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl wherein the substituents on the pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl, or naphthyl are independently selected from CF.sub.3, cyano, nitro, N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, phenyl, OR.sup.6, halogen, C.sub.1-4 alkyl or C.sub.3-8 cycloalkyl;R is selected from hydrogen, cyano, OR.sup.6, CO.sub.2 R.sup.19, CON(R.sup.19).sub.2, tetrazole, isooxadiazole, unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, cyano, nitro, OR.sup.6, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, N(R.sup.19).sub.2, NR.sup.19 COR.sup.6, NR.sup.19 CON(R.sup.20).sub.2, NR.sup.19 SO.sub.2 R.sup.6, NR.sup.19 SO.sub.2 N(R.sup.20).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6 or C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, thienyl, furanyl or naphthyl wherein the substituents on the pyridyl, thienyl, furanyl or naphthyl are independently selected from CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, phenyl, OR.sup.6, halogen, C.sub.1-4 alkyl or C.sub.3-8 cycloalkyl;R.sup.2, R.sup.3 and R.sup.7 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.4-8 cycloalkyl, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.19, (CH.sub.2).sub.0-4 CON(R.sup.19).sub.2, (CH.sub.2).sub.0-4 COR.sup.6, (CH.sub.2).sub.2-4 OR.sup.6, (CH.sub.2).sub.1-4 CF.sub.3, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.6, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.19).sub.2 or (CH.sub.2).sub.1-4 CN;R.sup.8, R.sup.10, R.sup.15, R.sup.16, R.sup.17 and R.sup.18 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.6 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.9 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, CO.sub.2 R.sup.6, CON(R.sup.6).sub.2, (CH.sub.2).sub.1-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.19 and R.sup.20 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.1-4 CF.sub.3 ;R.sup.24 and R.sup.26 are each independently selected from hydrogen or OR.sup.28 ;R.sup.28 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or(CH.sub.2).sub.0-4 CF.sub.3 ;each X is independently selected from halogen, cyano, nitro, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.6 or (CH.sub.2).sub.0-4 CF.sub.3 ;m, p and q are each independently an integer of from zero to two provided that when q is zero, R.sup.26 is hydrogen;n, o, and s are each independently an integer of from zero to four; andv is an integer from zero to one;or a pharmaceutically acceptable salt thereof;provided that the compound is not (4S)-trans-4-(3,4-difluorophenyl)-2-oxooxazolidine-3-carboxylic acid-[1-(4-hydroxy-4-pyridin-2-yl-cyclohexyl)-(3R)-pyrrolidin-3-yl]amide.