Patent ID: 6316472
Filing Date: 2001-11-13
Classification: A61K,A61P,C07D

Abstract:
A compound represented by formula I: ##STR21##or a pharmaceutically acceptable salt or hydrate thereof wherein:Y represents N or N-oxide;y represents 0, 1 or 2;R.sup.1 and R.sup.2 are independently selected from:H, C.sub.1-6 alkyl and haloC.sub.1-6 alkyl,R.sup.3 and R.sup.4 are independently selected from H and C.sub.1-6 alkyl, or R.sup.3 and R.sup.4 attached to the same carbon atom taken together represent a carbonyl oxygen atom, orR.sup.3 and R.sup.4 attached to different carbon atoms considered in combination with the carbon atoms to which they are attached along with any intervening atoms and represent a saturated 5, 6 or 7 membered carbocyclic ring,R.sup.5 and R.sup.6 independently represent a member selected from the group consisting of: H, C.sub.1-6 alkyl, haloC.sub.1-6 alkyl and CN;n represents an integer of from 0-6;Ar.sup.1 is selected from the group consisting of:(a) thienyl,(b) thiazolyl,(c) pyridyl,(d) phenyl and(e) naphthyl,said Ar.sup.1 being optionally substituted with 1-3 members selected from the group consisting of:(1) halo,(2) C.sub.1-6 alkoxy,(3) C.sub.1-7 alkylthio,(4) CN,(5) C.sub.1-6 alkyl,(6) hydroxy C.sub.1-6 alkyl,(7) --C(O)C.sub.1-6 alkyl, --CO.sub.2 H, --CO.sub.2 C.sub.1-6 alkyl,(8) NH(SO.sub.2 Me), N(SO.sub.2 Me).sub.2,(9) SO.sub.2 Me, SO.sub.2 NH.sub.2, SO.sub.2 NHC.sub.1-6 alkyl, SO.sub.2 N(C.sub.1-6 alkyl).sub.2(10) NO.sub.2,(11) C.sub.2-6 alkenyl,(12) halo C.sub.1-6 alkyl, and(13) NH.sub.2,and when Ar.sup.1 represents a phenyl or naphthyl group with two or three substituents, two such substituents may be considered in combination and represent a 5 or 6 membered fused lactone ring.