Patent ID: 7312206
Filing Date: 2007-12-25
Classification: A61K,C07J

Abstract:
1. A sterol derivative according to general formula (1): wherein; said cation is a nitrogen base selected from the group consisting of piperazines, imidazoles, morpholines, purines, pyrimidines, and pyridines; said spacers 1 and 2 are independently linear, or branched C said linking group X is selected from the group consisting of —(C═O)—O— and —(C═O)—NH—; said linking group Y is selected from the group consisting of —O—(O═C)—, —NH—(O═C)——(C═O)—O—, and —(C═O)—NH—; said sterol is selected from the group consisting of cholesterol, sitosterol, campesterol, desmosterol, fucosterol, 22-ketosterol, 20-hydroxysterol, stigmasterol, 22-hydroxycholesterol, 25-hydroxycholesterol, lanosterol, 7-dehydrocholesterol, dihydrocholesterol, 19-hydroxycholesterol, 5α-cholest-7-en-3β-ol, 7-hydroxycholesterol, epicholesterol, ergosterol, and dehydroergosterol; and said sterol derivative has a pKa value of between about 3.5 and about 8.