Patent ID: 8193207
Filing Date: 2012-06-05
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or pharmaceutically acceptable salt thereof, wherein: Cy is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 —W—X—Y—Z; L is absent, CO or SO Q is —(CR A is cycloalkyl, heterocycloalkyl or heteroaryl, each optionally substituted with 1, 2, 3, 4 or 5 —W′—X′—Y′—Z′; E is —(CR R R R or R or R or R or R or R or R or R or R or R or R R W, W′ and W″ are independently selected from absent, C X, X′ and X″ are independently selected from absent, C Y, Y′ and Y″ are independently selected from absent, C Z, Z′ and Z″ are independently selected from H, halo, CN, NO wherein two —W—X—Y—Z attached to the same atom optionally form a 3-20 membered cycloalkyl or heterocycloalkyl group, each optionally substituted by 1, 2 or 3 —W″—X″—Y″—Z″; wherein two attached to the same atom optionally form a 3-20 membered cycloalkyl or heterocycloalkyl group, each optionally substituted by 1, 2 or 3 —W″—X″—Y″—Z″; wherein —W—X—Y—Z is other than H; wherein —W′—X′—Y′—Z′ is other than H; wherein —W″—X″—Y″—Z″ is other than H; R R R or R R or R R or R R m is 0, 1, 2 or 3; n1 is 1, 2, 3 or 4; n2 is 0, 1, 2, 3 or 4; and r is 1 or 2.