Patent ID: 6667306
Filing Date: 2003-12-23
Classification: C07D

Abstract:
A compound of formula (I): wherein:W is carbon or nitrogen, wherein at least one W is a carbon; Y is nitrogen, oxygen, or sulfur; R1 is, independently, H, C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, pyridyl, pyrimidinyl, hydroxyl, C1-C6 alkoxy, phenoxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, monoarylamino, diarylamino, nitro, fluoro, chloro, bromo, iodo, C1-C6 alkylsulfonyl, hydroxycarbonyl, C1-C6 alkoxycarbonyl, absent if W is a nitrogen, or adjacent R1 groups together can form a five- or six-membered alicyclic ring, a six-membered aromatic ring, or a six-membered heteroaromatic ring having from one to two nitrogens, with the proviso that when a sequence of three Wâ€”R1 groups form a &boxH;Nâ€”C(R1)&boxH;Nâ€” sequence, the R1 bound to carbon is other than a halogen; R2 and R3 are, independently, H, C1-C6 alkyl, C3-C8 cycloalkyl, or R2 and R3 together form an alicyclic ring containing 3 to 8 carbon atoms; and R4 is a 5- or 6-membered monocyclic or a 5,6-fused bicyclic heterocyclic group having from one to five heteroatom ring members selected from the group consisting of N, O and S, optionally substituted with from 1 to 8 members independently selected from the group consisting of C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, pyridyl, pyrimidinyl, hydroxyl, C1-C6 alkoxy, phenoxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, monoarylamino, diarylamino, nitro, fluoro, chloro, bromo, iodo, C1-C6 alkylsulfonyl, hydroxycarbonyl and C1-C6 alkoxycarbonyl.