Patent ID: 7811982
Filing Date: 2010-10-12
Classification: A61K,A61P,C07K

Abstract:
1. A compound for treating cancer comprising: an anti-cancer chemotherapeutic agent linked to an insulin-like growth factor-1 (IGF-1) receptor ligand; wherein the IGF-1 receptor ligand is a variant IGF-1 that has reduced binding affinity for soluble IGF-1 binding proteins compared to wild-type IGF-1; wherein the variant IGF-1 comprises the polypeptide structure A A1 is FV; A2 is N; A3 is Q; A4 is H; A5 is S; A6 is H; A7 is E; A8 is Y; A9 is L; and R1 is SEQ ID NO:6; provided the variant IGF-1 does not consist of SEQ ID NO:1.