Patent ID: 6225322
Filing Date: 2001-05-01
Classification: A61P,C07D

Abstract:
A compound having the formula: ##STR35##or a pharmaceutically acceptable salt or solvate thereof, wherein:A is alkyl, halo or H;B is methyl, halo or H;the dotted line represents an optional double bond;R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of H, --CF.sub.3, --COR.sup.10, alkyl or aryl, said alkyl or aryl optionally being substituted with --OR.sup.10, --SR.sup.10, --S(O).sub.t R.sup.11, wherein t is 0, 1 or 2, --NR.sup.10 COOR.sup.11, --N(R.sup.10).sub.2, --NO.sub.2, --COR.sup.10,--OCOR.sup.10, --OCO.sub.2 R.sup.11, --CO.sub.2 R.sup.10 or OPO.sub.3 R.sup.10 or R.sup.5 is combined with R.sup.6 to represent .dbd.O or .dbd.S and/or R.sup.7 is combined with R.sup.8 to represent .dbd.O or .dbd.S;R.sup.10 represents H, alkyl, aryl, or aralkyl;R.sup.11 represents alkyl or aryl;R is --C(O)R.sup.1, --C(O)-OR.sup.1, --C(O)NR.sup.1 R.sup.2, --S(O).sub.2 -R.sup.1, and --S(O).sub.2 NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of H, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, C3-C6 cycloalkyl, cycloalkylalkyl, heterocycloalkyl, substituted alkyl, substituted aryl, substituted arylalkyl, substituted heteroaryl, substituted heteroarylalkyl, substituted (C3-C6) cycloalkyl, substituted cycloalkylalkyl, substituted heterocycloalkyl, wherein said substituted groups have one or more substituents selected from: C.sub.1 -C.sub.6 alkyl, alkoxy, aralkyl, heteroarylalkyl, --NO.sub.2, alkyloxyalkyl, alkyloxyalkyloxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, aryl, --CN, heteroaryl, heterocycloalkyl, .dbd.O, --OH, amino, substituted amino, nitro and halo, with the proviso that R.sup.1 is not H for --C(O)-OR.sup.1 or for --S(O).sup.2 R.sup.1.