Patent ID: 6350470
Filing Date: 2002-02-26
Classification: A61K,Y10S

Abstract:
A dosage form for delivery of a therapeutically effective amount of a drug to a target area in the gastrointestinal tract of a mammal; comprising:(a) a therapeutically effective amount of a drug; (b) at least one effervescent penetration enhancer; wherein said at least one effervescent penetration enhancer is present in an amount sufficient to increase the penetration of said drug across said target area of said gastrointestinal tract to permit delivery of a therapeutically effective amount of said drug; (c) a pH adjusting substance comprising an acid or a base; and (d) an enteric coating maintained over said drug, said at least one effervescent penetration enhancer and said pH adjusting substance; wherein said enteric coating prevents the release of said drug, said at least one effervescent penetration enhancer and said pH adjusting substance until a time at which said dosage form reaches said target area in said gastrointestinal tract.