Patent ID: 6169092
Filing Date: 2001-01-02
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula (I) ##STR111## in which E, G. L and M are identical or different and represent a nitrogen atom or a residue of a formula --C--A, wherein at least one of the subltituents E, G, L or M, must represent a nitrogen atom and wherein A represents hydrogen straight-chain or branched acyl or alkoxy-carbonyl each having up to 6 carbon atoms or straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by carboxyl, halogen, hydroxyl, straight-chain or branched alkoxycarbonyl, or alkoxy, each having up to 6 carbon atoms, phenoxy, benzoyl or by a group of a formula --O--CO--CH.sub.3, or represents halogen, carboxyl, cyano, nitro, trifluoromethyl, trifluoromethoxy or a group of a formula --OR.sup.5 --, --S(O).sub.n R.sup.6, --(O--CH.sub.2 --CO).sub.b --NR.sup.7 R.sup.8, --CO--NR.sup.9 R.sup.10, --SO.sub.2 --NR.sup.11 R.sup.12 or --NH--SO.sub.2 R.sup.13, in which R.sup.6, R.sup.8, R.sup.10 and R.sup.12 are identical or different and denote hydrogen, cycloalkyl having 3 to 6 carbon atoms, benzyl or a 5 to 7-membered saturated or unsaturated heterocycle having up to 3 heteroatoms from the series comprising N, S and O and to which a phenyl ring can be fused and which is optionally substituted by identical or different substituents from the series comprising halogen, cyano, nitro or by a straight-chain or branched alkyl having up to 6 carbon atoms or denote straight-chain or branched alkenyl or acyl each having up to 8 carbon atoms, or denote phenyl, which is optionally monosubstituted to disubstituted by identical or different substituents from the series comprising nitro, halogen, carboxy or straight-chin or branched alkoxycarbonyl having up to 6 carbon atoms, R.sup.7, R.sup.9 and R.sup.11 are identical or different and denote hydrogen or a straight-chain or branched alkyl having up to 4 carbon atoms, or R.sup.7 and R.sup.8 together with the nitrogen atom form a 5- to 6-membered heterocycle, R.sup.5 has the abovementioned meaning of R.sup.6, R.sup.8, R.sup.10 or R.sup.12 and is identical or different from the latter, or R.sup.5 denotes a hydroxyl protecting group or straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by carboxyl, hydroxyl, straight-chain or branched acyl or alkoxycarbonyl each having up to 6 carbon atoms, phenoxy, benzoyl or by a 5- to 7-membered unsaturated heterocycle having up to 3 heteroatoms from the series comprising N, S and/or O which is optionally substituted by halogen, cyano, nitro, or, by straight-chain or branched alkyl having up to 6 carbon atoms, and/or alkyl is substituted by a croup of a formula --(CO).sub.g --NR.sup.14 R.sup.15 in which R.sup.14 and R.sup.15 are identical or different and have the above-mentioned meaning of R.sup.7 and R.sup.8 and c denotes a number 0 or 1, or R.sup.5 denotes a group of the formula --SO.sub.2 --R.sup.16 R.sup.16 phenyl, trifluoromethyl or straight-chain or branched alkyl having up to 4 carbon atoms, a denotes a number 0, 1 or 2, b denotes a number 0 or 1, R.sup.13 has the abovementioned meaning of R.sup.16 and is identical or different from the latter, or E and G represent the CH-group and L and M represent a residue of a formula --CD and --CD' in which D and D' together form a pyridine ring, R.sup.1 represents hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, an aminoprotecting group or a group of the formula --CO--R.sup.17 in which R.sup.17 denotes hydroxyl, straight chain or branched alkoxycarbonyl having up to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, pyridyl, pyrrolidinyl or straight chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by halogen, carboxyl or straight chain or branched alkoxycarbonyl having up to 6 carbon atoms, or denotes phenyl, which is optionally substituted by hydroxyl, carboxyl or straight chain or branched alkoxy or alkoxycarbonyl each having up to 6 carbon atoms, T represents an oxygen or sulfur atom, R.sup.2 and R.sup.3 are identical or different and represent hydrogen, cycloalkyl, having up to 6 carbon atoms, straight chain or branched alkyl alkoxycarbonyl or alkenyl each having up to 8 carbon atoms, or represent benzoyl or aryl having 6 to 10 carbon atoms, which are optionally monosubstituted to trisubstituted by identical or different substituents from the series comprising halogen, cyano, nitro, carboxyl, straight-chain or branched alkyl, alkoxy, alkoxycarbonyl or acyl each having up to 6 carbon atoms, or represent a group of a formula --P(O)(OR.sup.18 (OR.sup.19), in which R.sup.18 and R.sup.19 are identical or different and denote hydrogen or straight chain or branched alkyl having up to 6 carbon atoms, or R.sup.2 and R.sup.3 together with the nitrogen atom form a 5- to 7-membered saturated heterocycle optionally having a further O atom, and R.sup.4 represents aryl having 6 to 10 carbon atoms or represents a 5 to 7 membered, saturated or unsaturated heterocycle, which can contain up to 4 oxygen, sulphur and/or nitrogen atoms as heteroatoms and to which further a benzene ring can be fused and wherein both rings are optionally monosubstituted to trisubstituted by identical or different substituents from the series comprising hydroxyl, halogen, nitro, 1H-tetrazolyl, pyridyl, trifluoromethyl, trifluoromethoxy, difluoromethyl, difluoromethoxy, cyano, carboxy, straight-chain or branched alkoxy, alkoxycarbonyl or acyl each having up to 8 carbon atoms or by straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by carboxyl or straight-chain or branched alkoxycarbonyl having up to 5 carbon atoms or by a group of a formula --NR.sup.20 R.sup.21, --SR.sup.22, SO.sub.2 R.sup.23 or --O--SO.sub.2 R.sup.24, in which R.sup.20 and R.sup.21 have the meaning shown above for R.sup.7 and R.sup.8,or R.sup.20 denotes hydrogen, and R.sup.21 denotes straight-chain or branched acyl having up to 6 carbon atoms, R.sup.22 denotes straight-chain or branched alkyl having up to 6 carbon atoms, R.sup.23 and R.sup.24 are identical or different and represent straight-chain or branched alkyl having up to 6 carbon atoms, benzyl or phenyl which are optionally substituted by trifluoromethyl, halogen or straight-chain or branched alkyl having up to 6 carbon atoms; Q represents an oxygen or sulfur atom. and a salt thereof.