Patent ID: 7825131
Filing Date: 2010-11-02
Classification: A61P,C07D

Abstract:
1. A compound of the structure: or a pharmaceutically acceptable salt thereof, wherein A is fluorophenyl or chlorophenyl; R 1 is selected from the group consisting of hydrogen, —CH 2 CH(OH)CH 2 OH, CH 2 CHCH 2 , R 2 , R 8 , R 9 and R 10 are independently selected from: 1) hydrogen, 2) halogen, 3) NO 4) CN, 5) CR 6) C≡CR 7) (CR 8) (CR 9) (CR 10) (CR 11) (CR 12) (CR 13) (CR 14) OS(O) 15) N(R 16) N(R 17) (CR 18) (CR 19) (CR 20) N(R 21) N(R 22) (CR wherein one of R 2 , R 8 , R 9 and R 10 represents —OCH 3 ; R a , R b , R c , R d , R e , R f , R g , R h , R i , R j , R k , and R l are independently selected from the group consisting of: 1) hydrogen, 2) C 3) halogen, 4) aryl, 5) R 6) C 7) OR said alkyl, aryl, and cycloalkyl being unsubstituted, monosubstituted with R 7 , disubstituted with R 7 , disubstituted with R 7 and R 15 , trisubstituted with R 7 , R 15 and R 16 , or tetrasubstituted with R 7 , R 15 , R 16 and R 4 , R 40 , R 41 , R 42 , R 43 , R 44 , R 45 , R 46 , R 47 , R 48 , R 49 , R 51 , and R 52 are independently selected from: 1) hydrogen, 2) C 3) C 4) aryl, 5) R 6) CF 7) C 8) C said alkyl, aryl, and cycloalkyl is unsubstituted, mono-substituted with R 18 , di-substituted with R 18 and R 19 , tri-substituted with R 18 , R 19 and R 20 , or tetra-substituted with R 18 , R 19 , R 20 and R 21 ; R 6 , R 60 , R 61 and R 63 are independently selected from: 1) C 2) aryl, 3) R 4) C said alkyl, aryl, and cycloalkyl is unsubstituted, mono-substituted with R 26 , di-substituted with R 26 and R 27 , tri-substituted with R 26 , R 27 and R 28 , or tetra-substituted with R 26 , R 27 , R 28 and R 29 ; R 7 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 26 , R 27 , R 28 , and R 29 are independently selected from: 1) C 2) halogen, 3) OR 4) CF 5) aryl, 6) C 7) R 8) S(O) 9) C(O)OR 10) C(O)R 11) CN, 12) C(O)N(R 13) N(R 14) S(O) 15) NO 16) N(R R 80 , R 81 , R 83 and R 84 are independently selected from a group of unsubstituted or substituted heterocyclic rings consisting of a 4-6 membered unsaturated or saturated monocyclic ring with 1, 2, 3 or 4 heteroatom ring atoms selected from the group consisting N, O and S, and a 9- or 10-membered unsaturated or saturated bicyclic ring with 1, 2, 3 or 4 heteroatom ring atoms selected from the group consisting or N, O or S; R R 11 is selected from the group consisting of 1) aryl, and 2) an unsubstituted or substituted heterocyclic ring consisting of a 4-6 membered unsaturated or saturated monocyclic ring with 1, 2, 3 or 4 heteroatom ring atoms selected from the group consisting N, O and S, and a 9- or 10-membered unsaturated or saturated bicyclic ring with 1, 2, 3 or 4 heteroatom ring atoms selected from the group consisting or N, O or S; and R 13 is selected from the group consisting of 1) C 2) C 3) C 4) C 5) CF n, p, q, r, and s are independently 0, 1, 2, 3, 4, 5 or 6.