Patent ID: 6831196
Filing Date: 2004-12-14
Classification: A61K,A61P,C07K

Abstract:
A urokinase inhibitor of the formula I: in which the substituent Y can be present in the 3 position or 4 position and is an amidino group in which R5 is an H, an OH or a carbonyl radical â€”COâ€”R or oxycarbonyl radical â€”COOâ€”R, where R can be a branched or unbranched alkyl having 1-16 C atoms, a substituted or unsubstituted aryl or heteroaryl radical or a substituted or unsubstituted aralkyl or heteroaralkyl radical,X is a CH group or N, R1 is H or a branched or unbranched alkyl having 1-8 C atoms or a (CH2)nâ€”OH in which n=1-5, R2 is an H or a branched or unbranched alkyl having 1-8 C atoms, R3 is a (CH2)nâ€”OH in which n=1-5 or is a branched or unbranched alkyl having 1-8 C atoms or is present in prodrug form and is a (CH2)nâ€”OX in which n=1-5, where X can be an alkyl, aralkyl or aralkylcarbonyl radical or a corresponding oxycarbonyl radical, and R4 is a sulfonyl radical â€”SO2â€”R, a carbonyl radical â€”COâ€”R, an oxycarbonyl radical â€”COOâ€”R or an H, where R is a branched or unbranched alkyl having 1-16 C atoms, a substituted or unsubstituted aryl or heteroaryl radical, a substituted or unsubstituted aralkyl or heteroaralkyl radical or an adamantyl radical or a camphor radical.