Patent ID: 6635621
Filing Date: 2003-10-21
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of formula (I) wherein:Y represents â€”C(O)â€” or â€”S(O2)â€”; R1 represents a radical of formula R6â€”(ALK)pâ€”(Z)nâ€”(ALK)qâ€” wherein Z represents â€”Oâ€” or â€”Sâ€”, ALK represents a divalent C1-C3alkyl or halogen-substituted C1-C3alkyl radical, p and q are independently 0 or 1, n is 0 or 1 when q is 1 and n is 0 when q is 0, and R6 is hydrogen or an optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, cycloalkenyl or heterocyclic group; or R1 together with the carbon atom to which it is attached forms a cycloalkyl ring; R2 represents â€”OR5 or â€”R5; R5 represents a radical of formula R7â€”(A)tâ€” wherein t is 0 or 1; A represents (i) an optionally substituted divalent C1-C6alkyl, radical which may be interrupted by one or more non-adjacent â€”Oâ€”, â€”Sâ€” or â€”NHâ€” linkages, or (ii) a divalent C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic radical, or (iii) a â€”NHâ€” link; and R7 represents hydrogen or an optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group; R3 represents (I) an optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group or (ii) NHR8 or N(R8)2 or (iii) OR8 wherein R8 represents hydrogen or an optionally substituted propyl, isopropyl, butyl, C5-C6alkyl, C2-C6alkenyl, C2C6alkynyl, cycloalkyl, cycloalkenyl or; A and B taken together represent a bond and R4 represents a hydroxy or substituted hydroxy group or an amino or primary or secondary amino group, or A represents hydrogen and B and R4 each independently represents a hydroxy or substituted hydroxy group; or a pharmaceutically acceptable salt, hydrate or solvate thereof.