Patent ID: 8974774
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K,C12Y,Y02A

Abstract:
1. A method of administering a biologically active protein to a subject in need thereof, the method comprising topically applying to the skin or epithelium of the subject a composition comprising a biologically active protein and a positively charged carrier in an effective amount for transdermal delivery of the biologically active protein, wherein the positively charged carrier comprises a polypeptide having attached thereto positively charged efficiency groups comprising (i) amino acid sequences selected from the group consisting of -(gly) wherein the biologically active protein excludes insulin, vascular endothelial growth factor (VEGF), and antibody fragments; wherein the composition does not comprise a negatively charged backbone; and wherein the positively charged carrier and the biologically active protein non-covalently and directly associate.