Patent ID: 8632452
Filing Date: 2014-01-21
Classification: A01K,C07K,C12N

Abstract:
1. An in vitro method of activating a peroxisome proliferator activated receptor δ (PPARδ) in a preimplantation mammalian embryo, comprising: 1) culturing said embryo in an embryo culture medium to form an in vitro cultured embryo; 2) adding a non-prostaglandin PPARδ ligand to said cultured embryo in vitro, wherein said ligand is added upon or after commencement of expression of PPARδ in the cells of the embryo; and 3) binding said non-prostaglandin PPARδ ligand to the expressed PPARδ to deter apoptosis in the cells of a cultured embryo and/or to increase proliferation of the cells of the cultured embryo in vitro.