Patent ID: 8519183
Filing Date: 2013-08-27
Classification: A61K,A61P

Abstract:
1. A method for alleviating pain in a mammal suffering therefrom comprising administering to said mammal an analgesic effective amount of a compound of the formula: wherein R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, and R is unsubstituted or, if substituted, is substituted with at least one electron withdrawing group or electron donating group; R R R wherein heterocyclic in R Z is O, S, S (O) Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, lower alkynyl, heterocyclic, heterocyclic lower alkyl, and Y may be unsubstituted or, if substituted, is substituted with an electron donating group or an electron withdrawing group, or ZY taken together is NR R R R R n is 1; and a is 1-3 wherein the electron withdrawing group and electron donating group are selected from the group consisting of halo, nitro, lower alkenyl, lower alkynyl, formyl, aryl, trifluoromethyl, aryl lower alkanoyl, hydroxy, lower alkoxy, lower alkyl, mercapto, lower alkylthio, and lower alkyldithio.