Patent ID: 6548533
Filing Date: 2003-04-15
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein:one of A1, A2 and A3 represents NR2 and the others represent C(R3)(R4); R1 represents R6N(R7)â€”C(&boxH;O)â€”NHâ€”Ar2â€”; R2 represents â€”(&boxH;O)â€”R8, â€”C(&boxH;O)â€”OR8a or R8b; R3 and R4 each represent hydrogen or R8; R6 represents hydrogen or lower alkyl and R7 represents arylor arylalkyl; R8 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or alkyl substituted by an acidic functional group or a protecting group, or by â€”Z3H, â€”Z2R10, â€”C(&boxH;O)â€”NY1Y2 or â€”NY1Y2; R8a represents alkyl, aryl or arylalkyl; R8b represents alkyl, aryl, arylalkyl or alkyl substituted by an acidic functional group or a protecting group; R9 represents aryl, cycloalkyl or cycloalkenyl; R10 represents alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl or cycloalkenylalkyl; R11 represents hydrogen or lower alkyl; R12 is a direct bond or an alkylene chain, an alkenylene chain or an alkynylene chain; R13 is â€”C(&boxH;O)â€”NHâ€”; Ar1 represents aryldiyl; Ar2 represents aryldiyl; L1 represents a â€”R12â€”R13â€” linkage; Y is carboxy; Y1 and Y2 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl or cycloalkyl; Z1 represents NH; Z2 is O or S(O)n; Z3 is O or S; and n is zero or an integer 1 or 2; provide that in these compounds an oxygen, nitrogen or sulphur atom is not attached directly to a carbon carbon multiple bond of an alkenyl or alkynyl residue;or a prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof or prodrug.