Patent ID: 9150588
Filing Date: 2015-10-06
Classification: A61P,C07D

Abstract:
1. A compound represented by formula (1), W 1 -W 2 (1), wherein: (i) W 1 is wherein ring A d is (A) C 3-8 cycloalkane, (B) a tetrahydronaphthalene ring, (C) a tetrahydropyridine ring optionally substituted by substituent(s) selected from the group consisting of (a) a C 1-6 alkyl group, (b) a C 1-6 alkyl group, (c) a C 1-6 alkyl group substituted by a phenyl group optionally substituted by a C 1-6 alkoxy group, and (d) a pyridyl group substituted by a halogen atom, (D) a piperidine ring optionally substituted by substituent(s) selected from the group consisting of (a) a naphthyl group, (b) a thiazolyl group, (c) a benzofuranyl group, (d) a dihydrobenzofuranyl group, (e) a tetrahydropyranyl group, (f) a thienyl group substituted by a halogen atom or a C 1-6 alkylcarbonyl group, (g) a methylenedioxyphenyl group substituted by a halogen atom, (h) a benzothiazolyl group optionally substituted by a C 1-6 alkyl group, (i) a C 1-6 alkylcarbonyl group, (j) a C 1-6 alkoxycarbonyl group substituted by a C 1-6 alkyl group, (k) a C 1-6 alkyl group optionally substituted by a phenyl group, (1) a phenylcarbonyl group optionally substituted by a halogen atom, (m) a carbamoyl group mono-substituted by a phenyl group, (n) a pyridyl group optionally substituted by substituent(s) selected from the group consisting of a halogen atom, a cyano group, and a C 1-6 alkyl group substituted by a halogen atom, and (o) a phenyl group optionally substituted by substituent(s) selected from the group consisting of a halogen atom, a C 1-6 alkyl group optionally substituted by a halogen atom, C 1-6 alkoxy optionally substituted by a halogen atom, a cyano group, a C 1-6 alkylcarbonyl group, a C 1-6 alkylsulfonyl group, a sulfur atom substituted by 1-5 halogen atoms, and an amino group di-substituted by a C 1-6 alkyl group, or (E) an azetidine ring substituted by substituent(s) selected from the group consisting of (a) a phenyl group, (b) a phenylcarboxy group, (c) a pyridyl group substituted by a C 1-6 alkyl group substituted by a halogen atom, and (d) a C 1-6 alkyl group di-substituted by a phenyl group, and R 1d is a hydrogen atom or a C 1-6 alkoxy group; and W 2 is wherein ring B d is a pyrazole ring, and R 2d is a phenyl group, or (ii) W 1 is wherein R 1e is a C 1-6 alkoxy group, R 3e is (a) a C 1-6 alkyl group substituted by a halogen atom, (b) a C 3-7 cycloalkyl group, (c) a tetrahydropyranyl group, (d) a piperidyl group, (e) a tetrahydrofuranyl group, (f) a pyrrolidyl group, (g) a morpholinyl group, (h) a quinolinyl group, (i) an isoquinolinyl group, (j) an oxetanyl group substituted by a C 1-6 alkyl group, (k) a phenyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a C 1-6 alkyl group substituted by a halogen atom, a C 1-6 alkoxy group, a C 1-6 alkoxycarbonyl group, a cyano group, and a phenyl group, (l) a pyridyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a C 1-6 alkoxycarbonyl group and a C 1-6 alkoxy group substituted by a halogen atom, or (m) a furyl group substituted by substituent(s) selected from the group consisting of a C 1-6 alkyl group substituted by a halogen atom and a C 1-6 alkoxycarbonyl group, and L e is a C 1-3 alkylene group optionally substituted by an oxo group or a sulfonyl group; and W 2 is wherein ring A e is a pyrazole ring, and R 2e is a phenyl group, or a pharmaceutically acceptable salt thereof.