Patent ID: 6815445
Filing Date: 2004-11-09
Classification: C07D,G01N

Abstract:
A compound of Formula I: whereinA is a single bond, alkylene, alkenylene, or alkynylene, wherein any of alkylene, alkenylene, and alkynylene is optionally substituted; R1 is cycloalkyl, cycloalkenyl, piperazine, pyrrolidine, aryl, imidazole, â€”OR3, â€”NR3R4, â€”SR3, â€”S(O)R3, â€”S(O)2R3, â€”C(O)H, â€”C(O)OR3, â€”C(O)NR3R4, â€”NR3C(O)R4, â€”OC(O)OR3, â€”OC(O)NR3R4, BR3C(O)OR4, â€”OS(O)2OR3, â€”S(O)2OR3, â€”S(O)OR3, â€”OP(O)(OR3)OR4, â€”P(O)(OR3)OR4, â€”P(O)HOR3, amidino, guanidino, biguanidino, oxyguanidino, alkyliminoamino, formyliminoamino, EDTA, nitrotriacetic acid, or histadine; and R2 is H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, or cycloalkyl, wherein any of alkyl, alkenyl, alkynyl, aryl, arylalkyl, and cycloalkyl is optionally substituted; and R3 and R4 are independently H, alkyl, alkenyl, alkynyl, aryl, or arylalkyl wherein any of alkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl is optionally substituted; and wherein A is a single bond; R1, R2, and A, together with N to which R1, R2, and A are attached, form a piperazine or thiazolidine group, either of which is optionally substituted; and salts thereof; with the provisos that, when A is C1-8 unsubstituted alkyl and R2 is H or methyl, then R1 is not â€”NH2, â€”NHCH3, â€”N(CH3)2, or â€”NHC(O)CH2Br; when A is C1-3 unsubstituted alkyl and R2 is H, then R1 is not â€”C(O)OH, â€”C(O)OCH3, or â€”C(O)OCH2CH3; when A is C1-3 unsubstituted alkyl and R2 is H, then R1 is not â€”NH(O)C6F5; when A is a single bond or alkylene, wherein alkylene represents methylene, and R2 is H or CH3, then R1 is not unsubstituted phenyl or phenyl phenyl substituted with â€”B(OH)2; and when A is a single bond, R1, R2, and A, together with N to which R1, R2, and A are attached, do not form unsubstituted morpholinyl.