Patent ID: 8996105
Filing Date: 2015-03-31
Classification: A61N

Abstract:
1. An active implantable medical device for treating a patient, comprising: means for delivering, during successive cardiac cycles, stimulation pulses adapted to be located at a vagus nerve, said stimulation pulses having an energy level suitable for stimulating the vagus nerve; a hemodynamic sensor measuring hemodynamic parameters of the patient's cardiac cycle, including left ventricular activity and a left ventricular filling time, and having a first output that is representative of the measured left ventricular filling time; means for adjusting the energy level of said stimulation pulses from a first level to a second level, operating dynamically and repeatedly over several cardiac cycles, and varying the energy level of the stimulation pulses during successive cardiac cycles; means for evaluating correlative changes in the ventricular filling time by comparing the ventricular filing time from the stimulation pulse at the second level to the ventricular filing time from the stimulation pulse at the first level, and determining an optimized ventricular filling time when the ventricular filling time from stimulation at the second level reaches a predetermined threshold ventricular filling value or is equal to the ventricular filling time from stimulation at the first level; and means for maintaining a stimulation pulse energy level corresponding to the optimized ventricular filling time.