Patent ID: 8067544
Filing Date: 2011-11-29
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated fully human monoclonal antibody or antigen-binding fragment thereof that specifically binds to human T cell, immunoglobulin domain and mucin domain 1 (TIM-1), wherein said antibody or antigen-binding fragment thereof specifically binds an epitope on TIM-1 comprising the amino acid sequence PMPLPRQNHEPVAT (SEQ ID NO: 87), and wherein said antibody or antigen-binding fragment thereof comprises a heavy chain amino acid sequence comprising three complementarity determining regions (CDRs) and a light chain amino acid sequence comprising three CDRs, where the three heavy chain CDRs and the three light chain CDRS are selected from: (a) a heavy chain CDR1 comprising the amino acid sequence GFIFSRYGMH (SEQ ID NO: 156), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSNKLYADSVKG (SEQ ID NO: 157), a heavy chain CDR3 comprising the amino acid sequence DYYDNSRHHWGFDY (SEQ ID NO: 158), a light chain CDR1 comprising the amino acid sequence RSSRSLLDSDDGNTYLD (SEQ ID NO: 159), a light chain CDR2 comprising the amino acid sequence TLSYRAS (SEQ ID NO: 160), and a light chain CDR3 comprising the amino acid sequence MQRVEFPIT (SEQ ID NO: 161); (b) a heavy chain CDR1 comprising the amino acid sequence GFTFTNYGLH (SEQ ID NO: 138), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSHKFYADSVKG (SEQ ID NO: 139), a heavy chain CDR3 comprising the amino acid sequence DLDY (SEQ ID NO: 140), a light chain CDR1 comprising the amino acid sequence RASQSVSNNYLA (SEQ ID NO: 141), a light chain CDR2 comprising the amino acid sequence GASSRAT (SEQ ID NO: 142), and a light chain CDR3 comprising the amino acid sequence QQYGSSLPLT (SEQ ID NO: 143); (c) a heavy chain CDR1 comprising the amino acid sequence GFTFSSYGMY (SEQ ID NO: 144), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSNKYYADSVKG (SEQ ID NO: 145), a heavy chain CDR3 comprising the amino acid sequence DFYDSSRYHYGMDV (SEQ ID NO: 146), a light chain CDR1 comprising the amino acid sequence RSSQSLLDSDDGNTYLD (SEQ ID NO: 147), a light chain CDR2 comprising the amino acid sequence TVSYRAS (SEQ ID NO: 148), and a light chain CDR3 comprising the amino acid sequence MQRIEFPIT (SEQ ID NO: 149); (d) a heavy chain CDR1 comprising the amino acid sequence GGSISSDGYYWS (SEQ ID NO: 150), a heavy chain CDR2 comprising the amino acid sequence YIYYSGSTFYNPSLKS (SEQ ID NO: 151), a heavy chain CDR3 comprising the amino acid sequence ESPHSSNWYSGFDC (SEQ ID NO: 152), a light chain CDR1 comprising the amino acid sequence RASQSIGSRLH (SEQ ID NO: 153), a light chain CDR2 comprising the amino acid sequence YASQSFS (SEQ ID NO: 154), and a light chain CDR3 comprising the amino acid sequence HQSSNLPFT (SEQ ID NO: 155); (e) a heavy chain CDR1 comprising the amino acid sequence GFTFSRYGMH (SEQ ID NO: 162), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSNKLYADSVKG (SEQ ID NO: 157), a heavy chain CDR3 comprising the amino acid sequence DYYDNSRHHWGFDY (SEQ ID NO: 158), a light chain CDR1 comprising the amino acid sequence RASQSIYSYLN (SEQ ID NO: 163), a light chain CDR2 comprising the amino acid sequence AASSLQS (SEQ ID NO: 164), and a light chain CDR3 comprising the amino acid sequence QQSYSTPPT (SEQ ID NO: 165); (f) a heavy chain CDR1 comprising the amino acid sequence GFTFRSYGMH (SEQ ID NO: 166), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSNKYYTDSVKG (SEQ ID NO: 167), a heavy chain CDR3 comprising the amino acid sequence DYYDNSRHHWGFDY (SEQ ID NO: 158), a light chain CDR1 comprising the amino acid sequence RASQGIRNDLA (SEQ ID NO: 168), a light chain CDR2 comprising the amino acid sequence AASSLQS (SEQ ID NO: 164), and a light chain CDR3 comprising the amino acid sequence LQHNSYPPS (SEQ ID NO: 169); g) a heavy chain CDR1 comprising the amino acid sequence GFTFSSYGMH (SEQ ID NO: 170), a heavy chain CDR2 comprising the amino acid sequence VIWYDGSHKYYADSVKG (SEQ ID NO: 171), a heavy chain CDR3 comprising the amino acid sequence DYYDTSRHHWGFDC (SEQ ID NO: 172), a light chain CDR1 comprising the amino acid sequence RSSQSLLDSEDGNTYLD (SEQ ID NO: 173), a light chain CDR2 comprising the amino acid sequence TLSHRAS (SEQ ID NO: 174), and a light chain CDR3 comprising the amino acid sequence MQRVEFPIT (SEQ ID NO: 161); (h) a heavy chain CDR1 comprising the amino acid sequence GFTFSNAWMT (SEQ ID NO: 175), a heavy chain CDR2 comprising the amino acid sequence RIKRRTDGGTTDYAAPVKG (SEQ ID NO: 176), a heavy chain CDR3 comprising the amino acid sequence VDNDVDY (SEQ ID NO: 177), a light chain CDR1 comprising the amino acid sequence RSSQSLLHSNGYNYLD (SEQ ID NO: 178), a light chain CDR2 comprising the amino acid sequence LGSNRAS (SEQ ID NO: 179), and a light chain CDR3 comprising the amino acid sequence MQALQTPLT (SEQ ID NO: 180); (i) a heavy chain CDR1 comprising the amino acid sequence GGSVSSGGYYWS (SEQ ID NO: 181), a heavy chain CDR2 comprising the amino acid sequence FIYYTGSTNYNPSLKS (SEQ ID NO: 182), a heavy chain CDR3 comprising the amino acid sequence DYDWSFHFDY (SEQ ID NO: 183), a light chain CDR1 comprising the amino acid sequence RASQGIRNDLG (SEQ ID NO: 184), a light chain CDR2 comprising the amino acid sequence AASSLQS (SEQ ID NO: 164), and a light chain CDR3 comprising the amino acid sequence LQHNSYPLT (SEQ ID NO: 185); (j) a heavy chain CDR1 comprising the amino acid sequence GFTFSNAWMT (SEQ ID NO: 175), a heavy chain CDR2 comprising the amino acid sequence RIKRKTDGGTTDYAAPVKG (SEQ ID NO: 186), a heavy chain CDR3 comprising the amino acid sequence VDNSGDY (SEQ ID NO: 187), a light chain CDR1 comprising the amino acid sequence RSSQSLLHSNGYNYLD (SEQ ID NO: 178), a light chain CDR2 comprising the amino acid sequence LGSNRAS (SEQ ID NO: 179), and a light chain CDR3 comprising the amino acid sequence MQALQTPLT (SEQ ID NO: 180); (k) a heavy chain CDR1 comprising the amino acid sequence GFTFTNYWMS (SEQ ID NO: 188), a heavy chain CDR2 comprising the amino acid sequence NIQQDGSEKYYVDSVRG (SEQ ID NO: 189), a heavy chain CDR3 comprising the amino acid sequence WDY (SEQ ID NO: 190), a light chain CDR1 comprising the amino acid sequence RSSQSLVHSDGNTYLN (SEQ ID NO: 191), a light chain CDR2 comprising the amino acid sequence MISNRFS (SEQ ID NO: 192), and a light chain CDR3 comprising the amino acid sequence MQATESPQT (SEQ ID NO: 193); and (l) a heavy chain CDR1 comprising the amino acid sequence GFTFSTYSMN (SEQ ID NO: 194), a heavy chain CDR2 comprising the amino acid sequence YIRSSTSTIYYAESLKG (SEQ ID NO: 195), a heavy chain CDR3 comprising the amino acid sequence DFDY (SEQ ID NO: 196), a light chain CDR1 comprising the amino acid sequence RSSQSLVHSDGDTYLN (SEQ ID NO: 197), a light chain CDR2 comprising the amino acid sequence KISTRFS (SEQ ID NO: 198), and a light chain CDR3 comprising the amino acid sequence MQTTQIPQIT (SEQ ID NO: 199).