Patent ID: 6245916
Filing Date: 2001-06-12
Classification: A61P,C07D,Y02P

Abstract:
A compound selected from those of formula (I): ##STR17##wherein:n is 0 or 1,W represents --CO-- or S(O).sub.q wherein q is 0, 1 or 2, ##STR18##represents a group selected from: ##STR19##Z represents alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, or optionally substituted arylalkynyl,A represents a grouping selected from --A.sub.2 --, --A.sub.1 --A.sub.2 --, --A.sub.2 --A.sub.1 --, and --A.sub.1 --A.sub.2 --A.sub.1 --, wherein A.sub.1 is alkylene and A.sub.2 represents optionally substituted phenylene, optionally substituted naphthylene, or cycloalkylene,R represents hydrogen, alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, or optionally substituted arylalkynyl, their enantiomers, diastereoisomers, or addition salt thereof with a pharmaceutically-acceptable acid or base, it being understood thatthe term ""alkyl"" denotes linear or branched alkyl having 1 to 6 carbon atoms,the term ""alkylene"" denotes linear or branched alkylene having 1 to 6 carbon atoms,the term ""alkenyl"" denotes linear or branched alkenyl having 2 to 6 carbon atoms and 1 to 3 double bonds,the term ""alkynyl"" denotes linear or branched alkynyl having 2 to 6 carbon atoms and 1 to 3 triple bonds,the term ""aryl"" denotes phenyl, naphthyl, biphenyl, dihydronaphthyl, or tetrahydronaphthyl,the terms ""phenylene"" and ""naphthylene"" denote bivalent phenyl and naphthyl radicals,the term cycloalkylene denotes a bivalent saturated cyclic radical having 3 to 8 carbon atoms,the expression ""optionally substituted"" applied to the terms ""aryl"" and ""arylalkyl"", means that those groups are substituted on their cyclic moiety by 1 to 5 identical or different substituents selected from linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, halogen, hydroxy, linear or branched perhalo-(C.sub.1 -C.sub.6)alkyl, nitro, amino (optionally substituted by one or two linear or branched (C.sub.1 -C.sub.6)alkyl), linear or branched (C.sub.1 -C.sub.6)acyl, aminocarbonyl (optionally substituted on the nitrogen atom by one or two linear or branched (C.sub.1 -C.sub.6)alkyl), linear or branched (C.sub.1 -C.sub.6)acylamino, linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl, formyl, carboxy, sulpho, nitrile, linear or branched (C.sub.1 -C.sub.6)aminoalkyl (optionally substituted on the nitrogen atom by one or two linear or branched (C.sub.1 -C.sub.6)alkyl), or linear or branched (C.sub.1 -C.sub.6)hydroxyalkyl (optionally substituted on the oxygen atom by a linear or branched (C.sub.1 -C.sub.6)alkyl), andthe expression ""optionally substituted"" applied to the terms ""phenylene"" or ""naphthylene"" means that those groups are substituted by one to three identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, halogen, hydroxy, linear or branched perhalo-(C.sub.1 -C.sub.6)alkyl, nitro, amino (optionally substituted by one or two linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)acyl, formyl, carboxy, linear or branched (C.sub.1 -C.sub.6)alkoxycarbonyl, aminocarbonyl (optionally substituted on the nitrogen atom by one or two linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)acylamino, and nitrile.