Patent ID: 9011915
Filing Date: 2015-04-21
Classification: A61K,A61P

Abstract:
1. A method of delivering the sustained release of an active agent to the eye of a subject comprising: administering, by injecting into the subconjunctiva, periocular space, retrobulbar in the orbit, episclera, intracornea, intrasclera, anterior chamber, anterior segment, posterior chamber, posterior segment, vitreous cavity, subretinal space, suprachorodial segment or intraretinal area of the eye, an injectable liquid pharmaceutical composition comprising: at least one excipient selected from the group consisting of tocopherol isomers and their esters, and tocotrienal isomers and their esters, wherein the amount of the excipient is sufficient to evenly dissolve or disperse the entire amount of the active agent in the composition; wherein upon initial injection the composition maintains its integrity as a single bolus; and wherein said excipient releases the active agent from the composition for a continuous and sustained period of at least about 60 days.