Patent ID: 8795665
Filing Date: 2014-08-05
Classification: A61K,A61P,C07K

Abstract:
1. An antibody, or antigen-binding fragment thereof, that binds to human BMP-6 (SEQ ID NO: 1), comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises the complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3, and the HCVR comprises the CDRs HCDR1, HCDR2, and HCDR3, wherein the LCDR1 is the polypeptide of RSSENIYRNLA (SEQ ID NO: 2), the LCDR2 is the polypeptide of AATNLAD (SEQ ID NO: 3), the LCDR3 is the polypeptide of QGIWGTPLT (SEQ ID NO: 4), the HCDR1 is the polypeptide of GYTFTSYAMH (SEQ ID NO: 5), the HCDR2 is the polypeptide of YINPYNDGTKYNENFKG (SEQ ID NO: 6) or YINPYNRGTKYNENFKG (SEQ ID NO: 7), and the HCDR3 is the polypeptide of RPFGNAMDI (SEQ ID NO: 8).