Patent ID: 6541009
Filing Date: 2003-04-01
Classification: A61K,A61P,C07K,C12N

Abstract:
A vaccine comprising a pharmaceutically acceptable excipient and an effective immunizing amount of a mutant herpesvirus, said mutant herpesvirus containing a genome in which a viral gene encoding a protein which is essential for the production of infectious virus has been deleted or inactivated, wherein said genome further includes a heterologous gene insert encoding an immunogenic protein, wherein said mutant virus is able to cause production of infectious new virus particles in a recombinant complementing host cell expressing a gene which complements said essential viral gene, but is unable to cause production of infectious new virus particles when said mutant virus infects a host cell other than said recombinant complementing host cell, for prophylactic or therapeutic use in generating an immune response in a subject infected therewith.