Patent ID: 8969341
Filing Date: 2015-03-03
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I) or a salt thereof, wherein A is selected from B is selected from R 1 is selected from chloro, fluoro and methyl; R 2 is selected from chloro, fluoro, trifluoromethyl, methyl and cyano; R 3 is selected from isopropyl, cyclopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, or R 3 is: wherein R 14 is selected from OH, methoxy, NH 2 , NMe 2 , NHMe, NHCOMe and NHCOH; R 4 is selected from H, —(C and wherein —(C —(C naphthyl, —(C —(C —(C —(C —(C and wherein the —(C 0 -C 4 )alkyl of —(C 0 -C 4 )alkyl-heterocyclyl 4 , when present, is optionally substituted with 1 or 2 OH, (C (C R 5 is selected from: H, heterocyclyl (C heterocyclyl (C cyano; R 6 is selected from H, (C (C (C halo, R cyano R R (C —O—(CH R 7 is selected from H, halo, (C (C (C R (C R 8 is selected from H, (C (C (C R 9 is H, methyl or ethyl; R 10 is H, methyl or ethyl, wherein said methyl and ethyl can each independently be substituted by 1 or 2 substituents independently selected from methoxy, ethoxy and halo; R 11 is H, methyl, methoxy or halo; R 12 is selected from H, (C —C(O)(C —C(O)O(C —C(O)H, and —C(O)-phenyl, optionally substituted with 1 or 2 substituents independently selected from (C R 13 is selected from —(C —(C (C —(C or R ═O, (C OH, C(O)(C C(O)O—(C C(O)NR m is 0, 1 or 2; n is 1, 2 or 3; p is 0, 1, 2 or 3; v is 0, 1 or 2; heterocyclyl 1 is a 3, 4, 5 or 6 membered fully saturated or partially unsaturated monocyclic group comprising ring carbon atoms and 1 or 2 ring heteroatoms independently selected from N, O and S; heterocyclyl 3 is a 4, 5 or 6 membered fully saturated or partially unsaturated monocyclic group comprising ring carbon atoms and 1 or 2 ring heteroatoms independently selected from N, O and S; heterocyclyl 4 is a 3, 4, 5, 6 or 7 membered fully saturated or partially unsaturated monocyclic group comprising carbon ring atoms and 1 or 2 ring atoms selected independently from N, O and S; heteroaryl 1 is a 5, 6, 7, 8, 9 or 10 membered, mono or bicyclic, fully unsaturated or partially unsaturated group, comprising carbon ring atoms and 1, 2, 3 or 4 ring heteratoms independently selected from N, O and S, wherein the total number of S atoms does not exceed 1, and the total number of O atoms does not exceed 1; heteroaryl 2 is 5 or 6 membered fully unsaturated monocyclic group comprising ring carbon atoms and 1, 2, 3 or 4 ring heteroatoms independently selected from N, O and S, wherein the total number of ring S atoms does not exceed 1, and the total number of ring O atoms does not exceed 1; and * indicates the point of attachment to the remainder of the molecule.