Patent ID: 6696439
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound of formula I: and pharmaceutical acid addition salts thereof, where;R is Eâ€”D is C&boxH;CH or CHâ€”CH2; R1 is hydrogen or C1-C4 alkyl; R2 is hydrogen, halo, hydroxy, â€”NR3R4, â€”SR3, â€”C(O)R3, â€”C(O)NR3R4, â€”NR3SO2R5, â€”NHC(Q)NR3R4, â€”NHC(O)OR3, or â€”NR3C(O)R5; R3, R4, and R5 are independently hydrogen, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or â€”(CH2)naryl; or R3 and R4 combine, together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, piperazine, 4-substituted piperazine, morpholine, or thiomorpholine ring; n is 0, 1, 2, 3, 4, 5, or 6; and Q is O or S.