Patent ID: 7750164
Filing Date: 2010-07-06
Classification: A61K,A61P,C07C,C07D,C07F

Abstract:
1. A method of preparing a compound having the structure: wherein Z is S or O; Y is (OR n is 2, 3 or 4; R R is linear or branched alkyl, alkoxyalkyl, substituted or unsubstituted aryloxyalkyl, trialkylsilyl, aryldialkylsilyl, diarylalkylsilyl, triarylsilyl, linear or branched acyl, substituted or unsubstituted aroyl or benzoyl; and R′ and R″ are independently hydrogen, a linear or branched alkyl, substituted or unsubstituted aryl or benzyl, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, a linear or branched acyl, substituted or unsubstituted aroyl or benzoyl; which comprises: cross-coupling a haloolefin having the structure: wherein X is a halogen, with a terminal hydroborane having the structure: wherein R* under suitable conditions to form a cross-coupled compound having the structure: