Patent ID: 6197959
Filing Date: 2001-03-06
Classification: A61P,C07D

Abstract:
A compound of formula: ##STR13##whereinR.sup.1 isa) --(CH.sub.2).sub.k --N(R.sup.3,R.sup.4), wherein k is 2, 3 or 4;b) --(CH.sub.2).sub.k --O--R.sup.3, wherein k is 2, 3 or 4;c) --(CH.sub.2).sub.m --R.sup.5, wherein m is 1 or 2; ord) --(CH.sub.2).sub.l --R.sup.6, wherein l is 1, 2 or 3;R.sup.2 is lower cycloalkylalkyl, 1,1,1-trifluoroethyl, phenyl, benzyl, phenyl substituted independently with from one to three halogen, cyano, C.sub.1 -C.sub.3 -alkoxy, or nitro groups, or benzyl substituted independently with from one to three halogen, cyano, C.sub.1 -C.sub.3 -alkoxy, or nitro groups;R.sup.3 is hydrogen or C.sub.1 -C.sub.3 -alkyl;R.sup.4 is hydrogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkylsulfonyl, aminosulfonyl, C.sub.1 -C.sub.3 -alkylaminosulfonyl, C.sub.1 -C.sub.3 -alkylaminocarbonyl, C.sub.1 -C.sub.3 -alkylcarbonyl, trifluoromethylcarbonyl, trifluoromethylsulfonyl, or aminocarbonyl;R.sup.5 is C.sub.1 -C.sub.3 -alkoxycarbonyl, aminocarbonyl, C.sub.1 -C.sub.3 -alkylaminocarbonyl, di-C.sub.1 -C.sub.3 -alkylaminocarbonyl, or cyano;R.sup.6 is imidazolyl or triazolyl, with the proviso that l must be 2 or 3 if the imidazolyl or triazolyl is bound via a C--N-bond;or a pharmaceutically acceptable salt thereof.