Patent ID: 7067655
Filing Date: 2006-06-27
Classification: A61P,C07D

Abstract:
1. A process of preparing a compound of formula II wherein R is R 1 -furanyl, R 1 -thienyl, R 1 -pyridyl, R 1 -pyridyl N-oxide, R 1 -oxazolyl, R 10 -phenyl, R 1 -pyrrolyl or C 4 –C 6 cycloalkenyl; R R R R (1) treating 2-amino-4,6-dihydroxypyrimidine with POCl 3 in dimethylformamide to obtain 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (2) treating carboxaldehyde VII with a hydrazide of the formula H (3) treating the intermediate of formula VIII with hydrazine hydrate to form a pyrazolo ring, thus obtaining the intermediate of formula IX (4) forming the desired compound of formula II by dehydrative rearrangement.