Patent ID: 6028053
Filing Date: 2000-02-22
Classification: A61K,C07K

Abstract:
A peptide of the formula IaX.sup.1 -A.sup.1 -A.sup.2 -X.sup.2 -Asn-X.sup.3 -X.sup.4 -P.Tyr-X.sup.5 -X.sup.6 -X.sup.7 Iawherein X.sup.1 represents Lys, Arg, His, X.sup.2 represents Glu, Asn, Tyr, Thr, Ser, X.sup.3 represents Pro, Met, Trp, Phe, Ala, Val, Leu, Ile, Gly, Cys, X.sup.4 represents Gln, Asp, Asn, Tyr, Thr, Ser, X.sup.5 represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, X.sup.6 represents Ser, Thr, Tyr, Asn, Glu, X.sup.7 represents Asp, Glu, and one of A.sup.1 and A.sup.2 represents Ile and the other of A.sup.1 and A.sup.2 represents Ile or Ala, which interferes with the interaction of a PTB domain containing protein with a PTB domain binding site.