Patent ID: 8771930
Filing Date: 2014-07-08
Classification: G01N,G06Q

Abstract:
1. A method of testing the toxicity of a substance, comprising: passing a perfusate comprising the substance under normothermic conditions and physiological oxygenation, osmolality, electrolyte balance and pH conditions through at least one metabolically active ex vivo donated human organ or tissue that was injured or diseased before donation, wherein perfusate comprising the substance further comprises about 15 to about 20% (v/v) matched human erythrocytes, about 2 to about 6% human serum albumin, N-acetylcysteine, and adenosine monophosphate (AMP); passing a perfusate under normothermic conditions and physiological oxygenation, osmolality, electrolyte balance and pH conditions that does not contain the substance through the at least one donated human organ or tissue before and/or after passing the at least one donated human organ or tissue with the perfusate comprising the substance, wherein collecting data derived from the perfused organ or tissue, wherein collecting data derived from the perfused organ or tissue comprises: analyzing the data to assess the toxicity of the substance, wherein the substance is selected from the group consisting of agricultural products, industrial products, building materials, tobacco products, cleaning products and cosmetics; wherein said at least one metabolically active ex vivo donated human organ or tissue is a glandular organ or tissue.