Patent ID: 6232449
Filing Date: 2001-05-15
Classification: A61K,A61P,C07K

Abstract:
An isolated and purified persephin polypeptide comprising a naturally occurring persephin amino acid sequence which contains amino acids at positions indicated in parentheses:Cys (1), Leu (3), Val (10), Leu (13), Gly (14), Leu (15), Gly (16), Tyr (17), Glu (21), (Phe(25), Arg (26), Tyr (27), Cys (28), Gly (30), Cys (32), Leu (44), Leu (47), Cys (58), Cys (59), Pro (61), Asp (66), Phe (69), Leu (70), Asp (71), Ser (83), Ala (84), Cys (87), and Cys (89),said positions being identified by alignment with a mouse persephin sequence as set forth in SEQ ID NO:79 or a rat persephin sequence as set forth in SEQ ID NO:82; wherein said persephin amino acid sequence has at least 65% sequence identity with SEQ ID NO:79 or SEQ ID NO:82, and wherein said persephin polypeptide promotes survival of mesencephalic cells and is from a nonmammalian species.