Patent ID: 7388010
Filing Date: 2008-06-17
Classification: A61K,A61P,C07D

Abstract:
1. A quinoxalinone derivative of the formula (I): or a pharmaceutically acceptable salt thereof, wherein X is NH; Y is O or NR′, wherein R′ is hydrogen or lower alkyl; the partial structure is the following formula: wherein B when B R B′ said lower alkyl and said lower alkenyl may be substituted with one or more, same or different substituents selected from the group consisting of hydroxy, lower alkoxy, amino and lower alkylamino, and among B′ B′ B′ B′ B′ B′ may form a C 5 -C 6 cycloalkyl or an aliphatic heterocyclic group selected from the substituent group β 1 mentioned below, and said cycloalkyl and said aliphatic heterocyclic group may be substituted with one or more, same or different substituents selected from lower alkyl and the substituent group a mentioned below; R is hydrogen, lower alkyl, lower alkenyl, amino in which the nitrogen atom is di-substituted with R R is a substituent selected from the substituent group α mentioned below, which may be substituted with one or more, same or different substituents selected from the substituent group γ mentioned below, or R is lower alkyl substituted with said substituent; or alternatively R is a cyclic group selected from the substituent group β in the above, the substituent group α, the substituent group β the substituent group α is a member selected from the group consisting of hydroxy, hydroxy-lower alkyl, cyano, halogen, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkoxy, lower alkoxyalkyl, amino, lower alkylamino, lower alkylsulfonyl, halogenated lower alkyl, halogenated lower alkoxy, halogenated lower alkylamino, nitro and lower alkanoylamino, the substituent group β the substituent group β the substituent group γ is a member selected from the group consisting of C 3 -C 6 cycloalkyl, lower alkyl substituted with C 3 -C 6 cycloalkyl, phenyl, lower alkyl substituted with phenyl, pyridyl, pyrrolidinyl and piperidinyl, said C 3 -C 6 cycloalkyl, phenyl, pyridyl, pyrrolidinyl and piperidinyl being optionally substituted with one or more fluorine atoms.