Patent ID: 6245333
Filing Date: 2001-06-12
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
An isolated tumor rejection antigen precursor which comprises the amino acid sequence set forth in SEQ ID NO:2, wherein said tumor rejection antigen precursor is encoded by a nucleic acid molecule which hybridizes under conditions of 3.5.times.SSC, 1.times.Denhardt's solution, 25 mM sodium phosphate buffer (pH 7.0), 0.5% SDS, and 2 mM EDTA for 18 hours, followed by four washes at 65.degree. for 20 minutes in 2.times.SSC, 0.1% SDS, and one wash of up to 20 minutes in 0.5.times.SSC, 0.1% SDS to the nucleic acid molecule of SEQ ID NO: 1, wherein said isolated tumor rejection antigen precursor is not tyrosinase and wherein said tumor rejection antigen precursor comprises a sequence of a tumor rejection antigen presented by HLA-B44 molecules.