Patent ID: 6765019
Filing Date: 2004-07-20
Classification: A61K,A61P

Abstract:
A prodrug having the following formula (I)R-(DRUG)â€ƒâ€ƒ(I) where the DRUG is a drug molecule covalently linked to R, and R is represented by the following formula (II) whereinY is selected from the group consisting of O, S and NR8, where R8 is selected from the group consisting of H or C1-C4 alkyl, C3-C4 branched alkyl and C3-C4 cycloalkyl; X is O or S; R1 is selected from the group consisting of OH, OR9, Oâ€”CH2â€”COOH, NH2 and +NH3Zâˆ’ where R9 is selected from the group consisting of C1-C4 alkyl, C3-C4 branched alkyl, and C3-C4 cycloalkyl and where Zâˆ’ is a pharmaceutically acceptable salt anion; R2 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; R3 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; R4 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; R5 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; R6 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; R7 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 hydroxyalkyl; and n is a number from 1 to 12; wherein the prodrug is selected from the group consisting of one of the following compounds: