Patent ID: 6133315
Filing Date: 2000-10-17
Classification: A61P,C07C,C07D

Abstract:
A compound having the Formula II: ##STR11## or solvates, hydrates or pharmaceutically acceptable salts thereof; wherein:Z is selected from the group consisting of --NR.sup.10 SO.sub.2 --, --SO.sub.2 NR.sup.10 --, --NR.sup.10 C(R.sup.y R.sup.z)--, --C(R.sup.y R.sup.z)NR.sup.10 --, --OSO.sub.2 --, --SO.sub.2 O--, --OC(R.sup.y R.sup.z)--, --C(R.sup.y R.sup.y)O--, --NR.sup.10 CO-- and --CONR.sup.10 --;R.sup.y and R.sup.z are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl and carboxy;R.sup.1 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl and heteroaryl, any of which may be optionally substituted;R.sup.2, R.sup.3 and R.sup.4 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamide, --CO.sub.2 R.sup.x, --CH.sub.2 OR.sup.x and --OR.sup.x, or when present on adjacent carbon atoms, R.sup.2 and R.sup.3 may also be taken together to form one of --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.q --, where q is from 2 to 6, and R.sup.4 is defined as above;R.sup.x, in each instance, is independently selected from the group consisting of hydrogen, alkyl and cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations;Y is selected from the group consisting of --O--, --NR.sup.10 --, --S--, --CHR.sup.10 -- and a covalent bond;W is selected from the group consisting of N and CR.sup.10 ;R.sup.6, in each instance, is independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano and --CO.sub.2 R.sup.w, where R.sup.w is alkyl or cycloalkyl;R.sup.7 and R.sup.8 are each independently selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl and carboxyalkyl, or when W is CR.sup.10, R.sup.7 and R.sup.8 can also be taken together to form --(CH.sub.2).sub.y --, where y is zero, 1 or 2;R.sup.10, in each instance, is independently selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino(C.sub.2-10)alkyl, dialkylamino(C.sub.2-10)alkyl and carboxyalkyl;n is from zero to 8, with the proviso that when W is N and Y is other than --CHR.sup.10 --, then n is from 2 to 8; andm is from 1 to 4, provided that when W is N, then m is not 1.