Patent ID: 7939630
Filing Date: 2011-05-10
Classification: A61K,A61P

Abstract:
1. A process for the preparation of a protein-polymer conjugate of formula I, wherein one of X and X′ is a polymer and the other is a hydrogen atom; Q is a linking group; W is selected from the group consisting of a keto group, an ester group, a sulphone group, a reduced keto group, a reduced ester group, and a reduced sulphone group; and if X represents a polymer, X′ and W together with the interjacent atoms may form a ring; A is a C B is a bond or a C Z is a single protein linked to A and B via two thiol groups generated by the reduction of a disulfide bridge in the protein; said method comprising the steps of: (a) reducing a disulfide bridge in the protein; and (b) reacting the reduced protein with either