Patent ID: 9045788
Filing Date: 2015-06-02
Classification: A61P,C07C,C07D,C12P,C12Y

Abstract:
1. A process for the synthesis of a compound of formula (IX): wherein R 1 represents a linear or branched C 1 -C 6 alkyl, allyl or benzyl group, by enantioselective enzymatic acylation of a racemic amine of formula (IV): using a lipase (EC 3.1.1.3 in the international classification of enzymes), with a carbonate of formula R in an amount ranging from 1 to 15 molar equivalents relative to the amine of formula (IV), in an organic or aqueous solvent, a mixture of organic solvents or a mixture of organic and aqueous solvents, at a concentration from 5 to 500 g/L of compound of formula (IV) per liter of solvent or mixture of solvents, at an Enzyme/Substrate ratio (E/S) of from 10/1 to 1/100, at a temperature from 25° C. to 40° C.