Patent ID: 6342374
Filing Date: 2002-01-29
Classification: A61K,A61P,C07K,C12N

Abstract:
A portable DNA sequence encoding a metalloproteinase inhibitor protein, said protein consisting essentially of an amino acid sequence selected from among the following:a) amino acid sequence SEQ ID NO: 1; or b) amino acid sequence SEQ ID NO: 2; or c) the amino acid sequences of a) or b), further having a Met at position âˆ’1; or d) the amino acid sequence of a) or b), further having a leader sequence at the N-terminal, âˆ’1 position, wherein said leader sequence consists essentially of the following amino acid sequence from positions âˆ’38 to âˆ’1: Gly His Arg Arg Arg Ser Ser Ala Gln Arg Asp Thr Arg Glu Pro Thr Met Ala Pro Phe Asp Pro Trp Leu Leu His Pro Val Val Ala Val Ala Asp Ser Pro Ser Arg Ala (SEQ ID NO: 3); or e) the amino acid sequence of a) or b) further having a leader sequence at the N-terminal, âˆ’1 position, wherein said leader sequence consists essentially of the following amino acid sequence from positions âˆ’22 to âˆ’1: Met Ala Pro Phe Asp Pro Trp Leu Leu His Pro Val Val Ala Val Ala Asp Ser Pro Ser Arg Ala (SEQ ID NO: 4).