Patent ID: 7348152
Filing Date: 2008-03-25
Classification: C07K

Abstract:
1. A method for detecting cancer in a sample comprising the steps of: (i) detecting the level of rhamnose binding protein (RBP) in the sample; and (ii) comparing it to the level of RBP in a sample from a non-cancer source, wherein said RBP has the following characteristics: i. the RBP has a molecular weight of about 65 kDa to about 70 kDa as determined by SDS-PAGE; ii. the RBP is insoluble in aqueous solution; iii. the RBP is adapted to bind to a rhamnose affinity column in the form of a streptavidin sepharose conjugated column or free resin with a theoretical capacity for biotin rhamnose ITC (BRITC) of 60 μg/ml, wherein the BRITC is coupled to the column by passing a phosphate buffered solution comprising an excess of BRITC dissolved therein over the column at a flow rate of about 0.2 ml/min for 30 minutes; and iv. the RBP is adapted to be eluted from said rhamnose affinity column with a 100 mM rhamnose solution.