Patent ID: 6534497
Filing Date: 2003-03-18
Classification: A61P,C07D

Abstract:
A compound having the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein:R1 is â€”Râ€², (C6-C20) aryl or substituted (C6-C20) aryl; R2 is â€”Râ€², â€”ORâ€², â€”SRâ€², halogen or trihalomethyl; R3 is â€”Râ€², â€”ORâ€², â€”SRâ€², halogen or trihalomethyl or, when taken together with R4, is (C6-C20) aryleno; R4 is â€”Râ€², â€”ORâ€², â€”SRâ€², halogen or trihalomethyl or, when taken together with R3, is (C6-C20) aryleno; each of R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 is independently selected from the group consisting of â€”Râ€², halogen and trihalomethyl; R15 is â€”Râ€³, â€”C(O)Râ€³, â€”C(S)Râ€³, â€”C(O)ORâ€³, â€”C(S)ORâ€³, â€”C(O)SRâ€³, â€”C(S)SRâ€³, â€”C(O)N(Râ€³)2, â€”C(S)N(Râ€³)2, â€”C(O)C(O)Râ€³, â€”C(S)C(O)Râ€³, â€”C(O)C(S)Râ€³, â€”C(S)C(S)Râ€³, â€”C(O)C(O)ORâ€³, â€”C(S)C(O)ORâ€³, â€”C(O)C(S)ORâ€³, â€”C(O)C(O)SRâ€³, â€”C(S)C(S)ORâ€³, â€”C(S)C(O)SRâ€³, â€”C(O)C(S)SRâ€³, â€”C(S)C(S)SRâ€³, â€”C(O)C(O)N(Râ€³)2, â€”C(S)C(O)N(Râ€³)2, â€”C(O)C(S)N(Râ€³)2 or â€”C(S)C(S)N(Râ€³)2; each Râ€² is independently selected from the group consisting of â€”H, (C1-C6) alkyl, (C2-C6) alkenyl and (C2-C6) alkynyl; each Râ€³ is independently selected from the group consisting of â€”H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C20) aryl, (C6-C20) substituted aryl, (C6-C26) alkaryl and substituted (C6-C26) alkaryl; and the aryl and alkaryl substituents are each independently selected from the group consisting of â€”CN, â€”ORâ€², â€”SRâ€², â€”NO2, â€”NRâ€²Râ€², halogen, (C1-C6)alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl and trihalomethyl, with the provisos that when R1 and R15 are each â€”H, at least one of R2, R3, R4, R5, R6, R7, R9, R10, R11, R12, R13 or R14 is other than â€”H, R8 is other than â€”H or â€”Cl and at least three of R2, R3, R4 and R5 are other than â€”OCH3; when R1-R7 and R9-R14, are â€”H, and R8 is â€”H or â€”Cl, then R15 is other than â€”H or â€”CH3; when R1-R7 and R9-R14 are â€”H and R8 is â€”F or â€”I or â€”Br, then R15 is other than â€”H; when R1 and R6-R15 are â€”H, then three of R2, R3, R4, and R5 are not â€”OCH3 at the same time; when R1-R5, R8 and R10-R15 are â€”H, then at least one of R6, R7 or R9 is other than â€”Cl; when R1 and R5-R14 are â€”H, and R15 is â€”CH3, then R2, R3 and R4 are not â€”OCH3 at the same time.