Patent ID: 8685990
Filing Date: 2014-04-01
Classification: A61P,C07D

Abstract:
1. A method for treating mild to severe pain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula 1 wherein R i) phenyl optionally substituted with one to two substituents independently selected from the group consisting of C ii) pyrimidinyl optionally substituted with one to two substituents independently selected from the group consisting of C iii) pyridinyl optionally substituted with one to two substituents independently selected form the group consisting of C and iv) a G-substituent selected from the group consisting of naphthyl, pyrazolyl, thienyl, benzothiazolyl, benzimidazolyl, quinolinyl, indolyl, thiazolyl, furanyl, dihydrobenzofuranyl, pyrazinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, isoxazolyl, oxazolyl, pyrrolopyridinyl, benzo[1,3]dioxol-5-yl, benzo[1,2,5]oxadiazolyl, dibenzothiophenyl, 4H-[1,2,4]oxadiazol-5-on-yl, benzothiophenyl, indazolyl, and 2,3-dihydrobenzo[1,4]dioxinyl; R (i) phenyl optionally substituted with one to three substituents independently selected from the group consisting of C (ii) 1,2-dihydrobenzofuranyl; provided that 1,2-dihydrobenzofuranyl is bound to O of Formula (I) at the benzo portion of the ring; and wherein the benzo portion of 1,2-dihydrobenzofuranyl is optionally independently substituted with one to two substituents selected from the group consisting of C or (iii) heteroaryl selected from the group consisting of benzothiazolyl, benzooxazolyl, pyridinyl, pyrimidinyl, indazolyl, quinolinyl, quinazolinyl, benzimidazolyl, pyrazinyl, triazinyl, benzothiophenyl, benzofuranyl, and isoquinolinyl; wherein heteroaryl of R A-L- is selected from the group consisting of a a a i) pyrrolidinyl optionally substituted at carbon with C ii) piperidinyl optionally substituted with C and iii) azetidinyl optionally substituted with 3-amino, 3-hydroxy, 3-C provided that when L and provided that when a L a i) piperazinyl optionally substituted at carbon with C and iii) morpholinyl optionally independently substituted with phenyl(C L a L a provided that a L a provided that when R or, A-L- is taken with R i) pyrrolidinyl wherein pyrrolidinyl is optionally substituted with C ii) piperazinyl optionally substituted with 4-C iii) piperidinyl optionally substituted with one to two C and, wherein the phenyl and the phenyl portion of phenyl(C iv) azetidinyl optionally substituted with 3-amino or 3-aminomethyl; v) [1,4]diazepan-1-yl optionally substituted with one to two C and vi) 3,6-diazoabicyclo[3.1.1]hept-3-yl optionally substituted with one to two C R provided that a compound of Formula (I) is other than a compound selected from the group consisting of a compound wherein R a compound wherein R a compound wherein R a compound wherein R a compound wherein R and a compound wherein R