Patent ID: 6323317
Filing Date: 2001-11-27
Classification: A01K,A61K,C07K,C12N,G01N

Abstract:
An isolated protein comprising a SOCS box, wherein the SOCS box comprises the amino acid sequence:X.sub.1 X.sub.2 X.sub.3 X.sub.5 X.sub.6 X.sub.7 X.sub.8 X.sub.9 X.sub.10 X.sub.11 X.sub.12 X.sub.13 X.sub.14 X.sub.15 X.sub.16 [X.sub.i ].sub.n X.sub.17 X.sub.18 X.sub.19 X.sub.20 X.sub.21 X.sub.22 X.sub.23 [X.sub.j ].sub.n X.sub.24 X.sub.26 X.sub.27 X.sub.28 (SEQ ID NO: 59)wherein:X.sub.1 is L, I, V, M, A or P;X.sub.2 is any amino acid residue;X.sub.3 is P, T or S;X.sub.4 is L, I, V, M, A or P;X.sub.5 is any amino acid;X.sub.6 is any amino acid;X.sub.7 is L, I, V, M, A, F, Y or W;X.sub.8 is C, T or S;X.sub.9 is R, K or H;X.sub.10 is any amino acid;X.sub.11 is any amino acid;X.sub.12 is L, I, V, M, A or P;X.sub.13 is any amino acid;X.sub.14 is any amino acid;X.sub.15 is any amino acid;X.sub.16 is L, I, V, M, A, P. G, C, T or S;[X.sub.i ].sub.n is a sequence of n amino acids wherein n is from 1 to 50 amino acids and wherein the sequence X.sub.1 can comprises the same or different amino acids selected from any amino acid residue;X.sub.17 is L, I, V, M, A or P;X.sub.18 is any amino acid;X.sub.19 is any amino acid;X.sub.20 L, I, V, M, A or P;X.sub.21 is P;X.sub.22 is L, I, V, M, A, P or G;X.sub.23 is P or N;[X.sub.j ].sub.n is a sequence of n amino acids wherein n is from 0 to 50 amino acids and wherein the sequence X.sub.j can comprise the same or different amino acids selected from any amino acid residue;X.sub.24 is L, I, V, M, A or P;X.sub.25 is any amino acid;X.sub.26 is any amino acid;X.sub.27 is Y or F; andX.sub.28 is L, I, V, M, A or P;with the proviso that said protein is not CIS.