Patent ID: 6973741
Filing Date: 2005-12-13
Classification: A61J,A61K,A61P,B01J

Abstract:
1. A process for producing a pharmaceutical composition comprising the steps: (a) forming a feed solution comprising a drug, a concentration-enhancing polymer and a solvent; (b) directing said feed solution to a spray-drying apparatus comprising wherein V dryer is measured in m 3 , H is at least 1 m, G is measured in m 3 /sec, and wherein the following mathematical relationship is satisfied (c) atomizing said feed solution into droplets in said drying chamber by said atomizing means, said droplets having an average diameter of at least 50 μm and a D (d) contacting said droplets with said heated drying gas to form particulates of a solid amorphous dispersion of said drug and said concentration-enhancing polymer; and (e) collecting said particulates.