Patent ID: 9035035
Filing Date: 2015-05-19
Classification: C07H,C12Q

Abstract:
1. A nucleotide conjugate (nuc-macromolecule) having the structure wherein: Base is selected independently from the group consisting of purine nucleobases, pyrimidine nucleobases and analogs of purine or pyrimidine nucleobases capable of forming Watson-Crick-base pairing, R R R R R a pharmaceutically acceptable salt thereof, and Linker is a linker component, which connects said Base and Polynucleotide 1, wherein the length of the Linker is in the range of from 5 to 100 chain atoms, and said Linker is attached covalently to the Base at one of the positions N wherein said Polynucleotide 1 is selected from the group consisting of at least one nucleic acid chain having a length of at least 10 nucleotide monomers, and at least one nucleic acid chain having a length of at least 10 nucleotide monomers wherein said nucleic acid chain is labeled with at least one Detectable Marker Unit.