Patent ID: 7323492
Filing Date: 2008-01-29
Classification: C07D

Abstract:
1. A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms and optionally substituted by one or more groups R selected from halogen, —NRaRb, C C C aryl, heteroaryl, hydroxy, —OC formyl, cyano, trifluoromethyl, —CHNORa, —CO —CONRaRb, —NRaC(O)Ra, —NRaC(O)ORa, —OC(O)NRaRb, —OC(O)Ra, —OC(O)ORa, or a C —NRaRb, —OC —SRa, —CHNORa, —CO —CONRaRb, —NRaC(O)Ra, —NRaC(O)ORa, —OC(O)NRaRb, —OC(O)Ra, —OC(O)ORa X represents —NRxRy or —OC 1-6 alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, amino and trifluoromethyl; Ra and Rb independently represent hydrogen or C 1-6 alkyl; R 1 represents hydrogen, C 1-6 alkyl or together R 1 and R 2 represent a CH 2 moiety; R 2 represents hydrogen, —OC 1-6 alkyl, —O(O)C 1-6 alkyl or hydroxy; R 3 represents hydrogen, hydroxy or together R 3 and R 1 represent a CH 2 moiety; R 4 represents hydrogen, or C 1-6 alkyl, optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, amino and trifluoromethyl; Rx and Ry independently represent hydrogen, benzyl, C 3-6 cycloalkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 1-6 alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, NRaRb and trifluoromethyl, —C 1-6 alkylcycloalkyl, —C 1-6 alkylheterocycle, C 1-6 alkylamino and C 1-6 alkylthio or together Rx and Ry form a heterocycle; and pharmaceutically acceptable salts thereof.