Patent ID: 6645939
Filing Date: 2003-11-11
Classification: C07D

Abstract:
A compound having the formula Ib: whereinR1 is phenyl optionally substituted with one or two groups selected from halogen, Oâ€”C1-3alkyl, and trifluoromethyl; R2 is H or methyl; B is O, S, a bond or CH2; A is â€”Câ€”; Y is â€”SO2; R4, R5, R6 are independently selected from H, C1-3 alkyl and halogen; R7 is hydrogen; R8 is aryl, heteroaryl, aryl-aryl, aryl-heteroaryl or heteroaryl-aryl wherein aryl and heteroaryl are optionally substituted with one to three groups selected from halogen, CN, ORd, O(CO)Re, C1-5alkyl optionally substituted with one or two groups selected from Rc, CF3, and OC(O)NRdRe; Rc is p31) halogen, 2) CN, 3) NH(C1-5alkyl), 4) N(C1-5alkyl)2, 5) amino, 6) carboxy, 7) C1-4alkyl, 8) C1-4alkoxy, 9) aryl, 10) aryl C1-4alkyl, or 11) aryloxy; Rd and Re are independently selected from hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, Cy and Cy-C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from Rc; or Rd and Re together with the atoms to which they are attached form a heterocyclic ring of 5 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen; Cy is cycloalkyl, heterocyclyl, aryl or heteroaryl.