Patent ID: 8349866
Filing Date: 2013-01-08
Classification: A61K,A61P,C07D

Abstract:
1. A high penetration composition comprising a structure selected form the group consisting of Structure P-1, Structure P-2, Structure P-3, Structure P-4, Structure P-5, Structure P-6, Structure P-7, Structure P-8, Structure P-9, Structure P-10, Structure P-11, Structure P-12, Structure P-14, Structure P-15, Structure P-16, Structure P-17, Structure P-18, Structure P-2A, Structure P-3A, Structure P-4A, Structure P-5A, Structure P-6A, Structure P-7A, Structure P-8A, Structure P-9A, Structure P-10A, Structure P-11A, Structure P-12A, Structure P-14A, Structure P-15A, Structure P-16A, Structure P-17A, and Structure P-18A: including stereoisomers and pharmaceutically acceptable salts thereof, wherein: L L L L HA is nothing or a pharmaceutically acceptable acid selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, nitric acid, sulfuric acid, bisulfuric acid, phosphoric acid, phosphorous acid, phosphonic acid, isonicotinic acid, acetic acid, lactic acid, salicylic acid, citric acid, tartaric acid, pantothenic acid, bitartaric acid, ascorbic acid, succinic acid, maleic acid, gentisinic acid, fumaric acid, gluconic acid, glucaronic acid, saccharic acid, formic acid, benzoic acid, glutamic acid, methanesulfonic acid, ethanesulfonic acid, benzensulfonic acid, p-toluenesulfonic acid and pamoic acid.