Patent ID: 8431563
Filing Date: 2013-04-30
Classification: A61P,C07C,C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: Y is —CF A is R —OC each R C —S(═O) —C(═O)C —CD —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —OC —(CR —OC —(CR each R X X X X each R C halo, —C≡CCF —C≡CCF —OC —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —C≡C—R —C≡C—(CR —C≡C—(CR —C≡C—(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —C≡C—(CR —C≡C—(CR —C≡C—(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR wherein the heteroaryl or heterocycloalkyl groups can have from 1 to 3 heteroatoms independently selected from O, N or S, and wherein substituted groups can have from one to four substitutents independently selected from —C —(CR —(CR or one or more carbon atoms in any ring group may be replaced with —C(═O)— or —S(═O) each n is independently 0, 1 or 2, provided that the compound is not 1,1,1,3,3,3-hexafluoro-2-(4-(4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; 1,1,1,3,3,3-hexafluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; 1,1,1,3,3,3-hexafluoro-2-(4-(4-((2-fluorophenyl)sulfonyl)-1-piperazinyl)phenyl)-2-propanol; 2-(4-(4-(3-chlorophenylsulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol; or 2-(4-(4-((2-chlorophenyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol.