Patent ID: 7241599
Filing Date: 2007-07-10
Classification: C12N,C12P

Abstract:
1. A method for producing (4R)-4-(indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid (4R-IHOG) or a salt thereof of formula(1): comprising reacting indole-3-pyruvic acid with pyruvic acid or oxaloacetic acid in the presence of a protein or a microorganism containing said protein to produce 4R-IHOG having an optical purity of at least 70%, wherein said protein is selected from the group consisting of (a) and (b): (a) a protein comprising the amino acid sequence in SEQ ID NO:2, and (b) a protein that is at least 95% homologous to the amino acid sequence in SEQ ID NO:2 and has 4R-aldolase activity.