Patent ID: 8753607
Filing Date: 2014-06-17
Classification: G01N

Abstract:
1. A diagnostic kit for determining a differential diagnosis in a non-invasive manner in an individual of Alzheimer's disease (AD) versus frontotemporal dementia (FTD) consisting of: a) reagents specific for TNF-α, FAS-L, and caspase-cleaved CK18, b) instructions for use of the reagents to determine levels of said TNF-α, FAS-L, and caspase-cleaved CK18 in biological samples obtained from such individual, c) optionally, a reference substance for each of said TNF-α, FAS-L, and caspase-cleaved CK18 for normalizing data, and d) an information sheet for comparing measured levels of said TNF-α, FAS-L, and caspase-cleaved CK18 to reference levels for each of said TNF-α, FAS-L, and caspase-cleaved CK18 to determine whether said individual is suffering from AD or FTD, and/or e) an information sheet for comparing the levels of TNF-α, FAS-L and caspase-cleaved CK18 to reference levels for each of said TNF-α, FAS-L and caspase-cleaved CK18 relating to severity of AD or FTD to determine the severity of AD or FTD in said individual.