Patent ID: 7465574
Filing Date: 2008-12-16
Classification: A61K,C07K,C12N

Abstract:
1. An isolated infectious Respiratory Syncytial Viral (RSV) particle which comprises an RSV antigenome or genome comprising (i) at least one functional deletion in the M2-2 open reading frame, and (ii) encoding one or more amino acid exchanges in the L protein at the following positions 135, 136, 146, 147, 148, 157, 158, 255, 256, 510, 511, 520, 568, 569, 587, 588, 1025, 1026, 1033, 1034, 1187, 1188, 1189, 1190, 1208, 1209, 1306, 1307, 1378, 1379, 1663, 1725, 1726, 1957, 1958, 2043, and 2044.