Patent ID: 6194425
Filing Date: 2001-02-27
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula I: ##STR178##whereinR.sub.1 is selected from the group consisting of:-hydrogen;-C.sub.1-20 alkyl or C.sub.2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisting of:-aryl;--O--C.sub.1-20 alkyl,--O--(C.sub.1-20 alkyl).sub.0-1-aryl;--C.sub.1-20 alkoxycarbonyl;--S(O).sub.0-2 --C.sub.1-20 alkyl;--S(O).sub.0-2 --(C.sub.1-20 alkyl).sub.0-1 -aryl;--N(R.sub.3).sub.2 ;--N.sub.3 ;oxo;-halogen;--NO.sub.2 ;--OH; and--SH; and--C.sub.1-20 alkyl-NR.sub.3 --Q--X--R.sub.4 or --C.sub.2-20 alkenyl-NR.sub.3 --Q--X--R.sub.4 wherein Q is --CO-- or --SO.sub.2 --; X is a bond, --O-- or --NR.sub.3 -- and R.sub.4 is aryl; or --C.sub.1-20 alkyl or C.sub.2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisiting of:-aryl;--O--C.sub.1-20 alkyl,--O--(C.sub.1-20 alkyl).sub.0-1 -aryl;--C.sub.1-20 alkoxycarbonyl;--S(O).sub.0-2 --C.sub.1-20 alkyl;--S(O).sub.0-2 --(C.sub.1-20 alkyl).sub.0-1 -aryl;--N(R.sub.3).sub.2 ;--NR.sub.3 --CO--O--C.sub.1-20 alkyl;--N.sub.3 ;oxo;-halogen;--NO.sub.2 ;--OH; and--SH; or R.sub.4 is ##STR179##wherein Y is --N-- or --CR--;R.sub.2 is selected from the group consisting of:-hydrogen;--C.sub.1-10 alkyl;--C.sub.2-10 alkenyl;-aryl;--C.sub.1-10 alkyl-O--C.sub.1-10 -alkyl;--C.sub.1-10 alkyl-O--C.sub.2-10 alkenyl; and--C.sub.1-10 alkyl or C.sub.2-10 alkenyl substituted by one or more substituents selected from the group consisting of:--OH;-halogen;--N(R.sub.3).sub.2 ;--CO--N(R.sub.3).sub.2 ;--CO--C.sub.1-10 alkyl;--N.sub.3 ;-aryl; and--CO-aryl;each R.sub.3 is independently selected from the group consisting of hydrogen and C.sub.1-10 alkyl; andeach R is independently selected from the group consisting of hydrogen, C.sub.1-10 alkyl, C.sub.1-10 alkoxy, halogen and trifluoromethyl, or a pharmaceutically acceptable salt thereof.