Patent ID: 8158406
Filing Date: 2012-04-17
Classification: C12P

Abstract:
1. A process for the enantioselective enzymatic reduction of keto compounds of formula I in which R1 stands for one of the moieties 1) —(C 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C wherein the moieties mentioned above under 1) to 7) are unsubstituted or substituted one, two or three times, independently of each other, by —OH, halogen, —NO and R 8) —(C 9) —(C 10) —(C 11) —(C wherein the moieties mentioned above under 8) to 11) are unsubstituted or substituted one, two or three times, independently of each other, by —OH, halogen, —NO comprising treating a liquid, single-phase mixture comprising (a) at least 5% by weight/by volume of a compound of formula (I), (b) at least 15% by volume of 2-propanol and/or 2-butanol, and (c) water with an R-specific oxidoreductase in the presence of a cofactor to form achiral hydroxy compound of general formula II wherein R and whereby the R-specific oxidoreductase continuously regenerates the cofactor by oxidation of the 2-propanol and/or the 2-butanol.