Patent ID: 6794414
Filing Date: 2004-09-21
Classification: A61K,C12N

Abstract:
A method of treating a disease mediated by transglutaminase, comprising administering to a patient in need thereof an effective amount of a transglutaminase inhibitor selected from the group consisting of monodansyl cadaverine, cystamine, putrescine, a monoamine, a diamine, gamma-amino benzoic acid, N-benzyloxy carbonyl, 5-deazo-4-oxonorvaline p-nitrophenylester, glycine methyl ester, CuSO4, and tolbutamide, wherein the disease is selected from the group consisting of Huntington's Disease, spinobulbar atrophy, spinocerebellar ataxia, Machado-Joseph disease, and dentatorubralpallidoluysian atrophy.