Patent ID: 6399793
Filing Date: 2002-06-04
Classification: C07C,C07D

Abstract:
A process for the preparation of &agr;-N-acyl-&agr;â€²-chloroketones represented by the formula wherein R is selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl and R1 is a protecting group for the amino function comprising reacting aryl esters represented by the formula wherein R and R1 are as defined above and R2 is hydrogen or nitro and may be substituted in the ortho or para position on the phenyl ring with a compound containing a function represented by the formula wherein R3 and R4 are selected from the group consisting of alkyl, substituted alkyl and aryl, to produce an intermediate keto ylide compound represented by the formula and treating said compound represented by formula III with a source of chloride and an organic acid.