Patent ID: 7750186
Filing Date: 2010-07-06
Classification: C07C,C07D

Abstract:
1. A method for the manufacture of a biphenyl amine of the general Formula (I) where R X X comprising, (1) reacting an anilide of Formula (II) with 2-methylbut-3-yn-2-ol of Formula (III) to obtain an alkynyl anilide of Formula (IV) (2) removing an acetone molecule from said alkynyl anilide of Formula (IV) in the presence of a base to form an ethynyl anilide of Formula (V) (3) reacting said ethynyl anilide of Formula (V) with an thiophene dioxide of Formula (VI) to obtain a biphenyl amide of Formula (VII) (4) removing the [—C(═O)R