Patent ID: 9180292
Filing Date: 2015-11-10
Classification: A61F,A61N

Abstract:
1. A delivery device for transferring a therapeutic substance across and/or through a surface of an ocular globe, comprising: an iontophoretic chamber configured to store the therapeutic substance; an electrode disposed relative to the iontophoretic chamber, the electrode configured to provide an electromotive force, when energized, to transfer of at least a portion of the therapeutic substance stored within the iontophoretic chamber across and/or through the surface of the ocular globe; a buffer system disposed at least partially within the at least one iontophoretic chamber, the buffer system does not contain the therapeutic substance, the buffer system configured to maintain a pH at the surface of the ocular globe within a range of about 3 to 8 during iontophoretic transfer of the therapeutic substance; and the iontophoretic chamber further comprises a first layer and a removable second layer, the first layer including the buffer system and the second layer including a therapeutic substance, wherein the first layer is disposed closest to the electrode and wherein the second layer including the therapeutic substance is configured to be removably coupled to the iontophoretic chamber.