Patent ID: 7825216
Filing Date: 2010-11-02
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
1. A conjugate of formula I: wherein: A is carboxyl, carboxyalkyl, dicarboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, dialkoxycarbonylalkyl, or a malonyl group of formula II: wherein R 1 and R 2 may be the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkylaryl, and heteroaryl; and R 3 is selected from the group consisting of hydrogen, halo, hydroxy, amino, alkyl, aryl, and alkoxy; B has the formula B1 or B2: wherein X is NH or O; R C is selected from the group consisting of hydrogen, hydroxyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, and alkoxycarbonyl alkyl; wherein said aryl, heteroaryl, and the aryl portion of said arylalkyl and alkylaryl may be unsubstituted or substituted with a substituent selected from the group consisting of alkyl, hydroxy, halo, keto, amino, and alkoxy.