Patent ID: 7199259
Filing Date: 2007-04-03
Classification: C07C

Abstract:
1. A process for enantioselectively producing a α-(phenoxy)phenylacetate compound of the formula: said method comprising: (a) resolving an enantiomeric mixture of a α-(phenoxy)phenylacetic acid of the formula: using an enantiomerically enriched chiral amine compound; to produce an enantiomerically enriched α-(phenoxy)phenylacetic acid, wherein the total amount of enantiomerically enriched chiral amine compound used is less than 0.5 molar equivalents with respect to the α-(phenoxy)phenylacetic acid compound; (b) producing an enantiomerically enriched activated α-(phenoxy)phenylacetic acid derivative by contacting the enantiomerically enriched α-(phenoxy)phenylacetic acid with a carboxylic acid activating reagent; and (c) contacting the enantiomerically enriched activated α-(phenoxy)phenyl-acetic acid derivative with a compound of the formula (R wherein R X is halide; R M is hydrogen or a metal; and the subscript w is the oxidation state of M.