Patent ID: 6403648
Filing Date: 2002-06-11
Classification: A61K,C07C

Abstract:
A therapeutic method for treating a circulatory-related disorder, said method comprising administering to a subject susceptible to a hypertensive condition a therapeutically-effective amount of a compound of Formula I: wherein each of R1 and R11 is a group independently selected from hydrido, alkyl, alkylaminoalkyl and phenyl; wherein n is a number selected from zero through five, inclusive; wherein x is a number selected from zero, one and two; wherein R2 is selected from hydrido and alkyl; wherein R3 is a group selected from hydrido, cycloalkylalkyl, aralkyl and haloaralkyl; wherein each of R4 and R6 is a group independently selected from hydrido and methyl; wherein R5 is selected from linear and branched alkyl groups containing from one to about four carbon atoms;; wherein R7 is a group selected from alkyl, cycloalkylalkyl and aralkyl; wherein R8 is a group selected from hydrido, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkenyl and haloalkenyl; wherein each of R9 and R10 is a group independently selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, alkylacyl, aryl, aralkyl, haloaryl and haloaralkyl; and wherein any one of said R1 through R11 groups having a substitutable position may be substituted with one or more groups selected from alkyl, hydroxy, hydroxyalkyl, halo, alkoxy, alkoxyalkyl and alkenyl; or a pharmaceutically-acceptable salt thereof.