Patent ID: 8669225
Filing Date: 2014-03-11
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A therapeutically-active, non-immunogenic nanoparticle formed by a method comprising: providing a prolamine; dissolving said prolamine with a hydroalcoholic solvent to provide a first aqueous phase solution and adding to said prolamine in the formation of the first phase solution a molecule that is selected for nanoparticle encapsulation; adding a buffering agent to the first aqueous phase solution in the presence of a surfactant and a phospholipid to produce a second aqueous phase solution having a pH of between approximately pH 6.8 and approximately pH 7.4; processing said second aqueous phase solution to effect a reduction in diameter size of particles within the solution; evaporating any residual solvent to produce nanoparticles having a diameter size of less than about 400 nm; and isolating said nanoparticles; wherein the nanoparticle consists essentially of a prolamine, a phospholipid, a surfactant, and a therapeutic or diagnostic agent.