Patent ID: 7105308
Filing Date: 2006-09-12
Classification: G01N

Abstract:
1. A method for detecting a dimer in a sample, the method comprising: mixing (i) a sample, which contains a dimer comprising a first membrane-associated analyte and a second membrane-associated analyte; (ii) a cleaving probe, which is capable of binding the first membrane-associated analyte and has a cleavage-inducing moiety with an effective proximity; and (iii) one or more binding compounds, at least one of which is capable of binding the second membrane-associated analyte, and each binding compound has one or more molecular tags attached thereto by a cleavable linkage, wherein cleavage of the cleavable linkage(s) within the effective proximity of the cleaving-inducing moiety of the cleaving probe releases the molecular tag(s); wherein detecting the released molecular tag(s) detects the dimer.