Patent ID: 6686445
Filing Date: 2004-02-03
Classification: A61K,C07K

Abstract:
A dolastatin 15 derivative of formula 13wherein R3 is selected from the group consisting of:NHPh, NHCH2Ph, NH(CH2)2Ph, NH(CH2)2-4-F-Ph, NH(CH2)2-4-Cl-Ph, NH(CH2)2-3-Cl-Ph, NH(CH2)2-2-Cl-Ph, NH(CH2)2-4-Br-Ph, NH(CH2)2-4-NO2-Ph, NH(CH2)2-3,4-(CH3O)2Ph, NH(CH2)2-2-pyridine, NH(CH2)3-Ph, L-Phe-OCH3, L-Met-OCH3, L-Pro-OCH3, HN-2-thiazoly, NH-2-benzothiazolyl, and NH-3-quinolyl.