Patent ID: 6096901
Filing Date: 2000-08-01
Classification: C07D

Abstract:
A process for the preparation of the compound of the formula: ##STR11## wherein R.sup.1 is OH, which comprises the steps of a) treating the compound of the formula: ##STR12## with an inorganic fluoride, of the formula M.sup.2 F wherein M.sup.2 is an alkali metal cation, at an elevated temperature in the presence of a compound of the formula (R.sup.4).sub.4 P.sup.+- Z and a compound of the formula R.sup.5 vic (COW).sub.2 wherein R.sup.4 and R.sup.5 are each selected from optionally substituted (C.sub.6 -C.sub.10) aryl and optionally substituted (C.sub.1 -C.sub.6) alkyl, and W is halo; to form the compound of the formula: ##STR13## and b) I) treating the compound of the formula IV with an aqueous solution of a base, of the formula MOH, wherein M is an alkali metal cation andii) treating the product of step i) with a mineral acid.