Patent ID: 7935795
Filing Date: 2011-05-03
Classification: A61K,A61P,C07K

Abstract:
1. A human monoclonal antibody or its antigen binding portion capable of binding to human granulocyte-macrophage colony stimulating factor (hGM-CSF) and neutralizing bioactivity of the hGM-CSF, wherein the anti-hGM-CSF monoclonal antibody or its antigen binding portion comprises (a) a light chain (L chain) complementarity determining region (CDR) 1 domain having the amino acid sequence of SEQ ID NO:5, (b) an L chain CDR 2 domain having the amino acid sequence of SEQ ID NO:6, (c) an L chain CDR 3 domain having the amino sequence of SEQ ID NO:7, (d) a heavy chain (H chain) CDR 1 domain having the amino sequence of SEQ ID NO:8, (e) an H chain CDR 2 domain having the amino acid sequence of SEQ ID NO:9, and (f) an H chain CDR 3 domain having the amino acid sequence of SEQ ID NO:10.