Patent ID: 6348207
Filing Date: 2002-02-19
Classification: A61K,A61Q,C07C,C07K

Abstract:
A method for delivering, by the oral route, a biologically active agent to a subject in need of said biologically active agent, said method comprising:(a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, an d an intermediate conformational state which is reversible to said native state and is conformationally between said native and denatured states; (b) exposing said biologically active agent to a complexing perturbant to reversibility transform said biologically active agent to said intermediate state and to form an orally deliverable supramolecular complex, said perturbant having a molecular weight between about 150 to about 600 daltons, and having at least one hydrophilic moiety and at least one hydrophobic moiety, said supramolecular complex comprising said perturbant non-covalently complexed with said biologically active agent, said biologically active agent not forming a microsphere with said perturbant, and said perturbant being present is in an amount effective for oral delivery of said biologically active agent; and (c) orally administering said supramolecular complex to said subject.