Patent ID: 6710060
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A compound represented by the following formula (I): whereinA represents a phenyl group, naphthyl group or monocyclic aromatic heterocyclic group each substituted by R1 and R2; R1 and R2 each independently represent hydrogen atom, halogen atom, trifluoromethyl group, cyano group, lower alkoxycarbonyl group, amino group unsubstituted or mono- or di-substituted by lower alkyl group, lower alkanoylamino group unsubstituted or substituted by fluorine atom, unprotected or protected hydroxyl group, lower alkoxy group, lower alkyl group, trifluoromethoxy group, nitro group, phenyl group, phenoxy group, unprotected or protected carboxyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, lower alkanoyl group, lower alkylthio group, lower alkylsulfinyl group, lower alkylsulfonyl group and sulfamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, or R1 and R2 together represent alkylenedioxy group; R3 represents hydrogen atom or Lower alkyl group; R4 represents hydrogen atom, lower alkyl group or lower alkanoyl group; R5 and R6 each independently represent hydrogen atom, halogen atom, lower alkoxy group unsubstituted or mono-substituted by unprotected or protected hydroxyl group, lower alkyl group, unsubstituted or mono-substituted by unprotected or protected hydroxyl group, phenoxy group, lower alkenyloxy group or unprotected or protected hydroxyl group; X represents a single bond, a group: â€”CH(OH)â€”, oxygen atom or carbonyl group; Y represents lower alkylene group, lower alkylidene group or benzylidene group substituted by R1, Y may form 5 or 6-membered ring together with X and carbon atoms on a benzene ring when A is phenyl group; Z represents a single bond or methylene group unsubstituted or substituted by a group arbitrarily selected from a group comprising lower alkyl group, lower alkoxy group or unprotected or protected hydroxyl group; and R7 and R8 each independently represent hydrogen atom or lower alkyl groups, provided that R5 and R6 do not simultaneously represent hydrogen atoms, or a salt thereof.