Patent ID: 8492403
Filing Date: 2013-07-23
Classification: A61P,C07D

Abstract:
1. A method of inhibiting one or more of NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.5, NaV1.6, NaV1.7, NaV1.8, NaV1.9, or CaV2.2 activity in: (a) a patient; or (b) a biological sample; wherein: one of X and W is N and the other of X and W is CH; ring Z is a 5-7 membered unsaturated or aromatic ring having at least one ring heteroatom selected from O, S, N, or NH, wherein Z is optionally substituted with up to z occurrence of R z is 0 to 4; each R the SO the ring containing W and X is optionally substituted with up to 4 substituents selected from halo, CN, NO Q is a bond or is a C1-C6 straight or branched alkylidine chain, wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR R wherein R R R n is 0, 1, or 2; Y is halo, CN, NO R R R R R R Z′ is selected from halo, CN, NO R