Patent ID: 6472418
Filing Date: 2002-10-29
Classification: A61P,C07D

Abstract:
A compound of Formula I and the pharmaceutically acceptable salt thereof, wherein&squf;, &Circlesolid;, &utrif;, indicate all stereoisomers, R is: furyl benzofuryl, or benzoxazolyl, wherein each of the foregoing is unsubstitute, mono-, di- or trisubstituted by alkyl, hydroxy, alkoxy, halogen, â€”CF3, carboxy, sulfonamide, or nitro; R1 and R2 are each independently H or C1-C4 alkyl; m is an integer from 0 to 3; X is NR8 where R8 is H or C1-C4alkyl; R3 is hydrogen or C1-C4 alkyl; n is an integer from 1 to 2; R4 is indolyl, wherein said groups are substituted, mono, di- or trisubstituted by alkyl, hydroxy or formyl; R9 is hydrogen or C1-C4 alkyl; R5 and R7 are each independently hydrogen or (CH2)pR10 where: p is an integer of 1 to 3, and R10 is H, CH3, CN, OH, OCH3, CO2CH3, NH2, NHCH3, or N(CH3)2; q is integer of 0 to 4; R6 is phenyl, wherein the foregoing is unsubstituted, mono-, di- or trisubstituted by alkyl, hydroxy, alkoxy, halogen, CF3, NO2, N(CH3)2, OCF3, SONH2, NH2, CONH2, CO2CH3, or CO2H, and R5 and R6 when joined by a bond, can form a ring.