Patent ID: 6451817
Filing Date: 2002-09-17
Classification: A61P,C07D,Y02P

Abstract:
A compound of formula I whereinR1 is H, OH, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2; R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl), or 4-cyclohexanol; R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, azepine, or pipecoline; R6 is â€ƒwherein each of R7 and R8 is taken separately and represents H, 2-hydroxyethyl, or 2-fluoroethyl provided that at least 1 of R7 and R8 is 2-hydroxyethyl or 2-fluoroethyl, or both R7 and R8 are taken together with the nitrogen and form a ring which is pyrrolidine, piperidine, azepine, or morpholino and which may optionally be substituted by one or two methyl groups, or â€ƒwherein each of R10 and R11 is taken separately and represents H or C1-C2, or both R10 and R11 are taken together with the nitrogen and represent a ring which is a pyrrolidine, piperidine, azepine or morpholino and which may optionally be substituted by one or two methyl groups, and R12 is hydrogen, methyl, or ethyl; and pharmaceutically acceptable salts thereof.