Patent ID: 6485943
Filing Date: 2002-11-26
Classification: C07K

Abstract:
A method for altering antibody light chain polypeptide interactions, comprising:providing a first nucleic acid sequence which codes for an immunoglobulin antibody kappa-IV light chain polypeptide, wherein the codon of the first nucleic acid which codes for position 38 of the immnunoglobulin antibody kappa-IV light chain polypeptide, numbered according to the Wu-Kabat convention, has been modified to code for a first charged amino acid selected from the group consisting of aspartic acid, glutamic acid, arginine, and lysine; expressing said first nucleic acid sequence to produce modified immunoglobulin antibody kappa-IV light chain polypeptides; and interacting said modified inmnunoglobulin antibody kappa-IV light chain polypeptides with each other.