Patent ID: 6221865
Filing Date: 2001-04-24
Classification: C07B,C07C,C07D,C07F

Abstract:
A compound having Formula I ##STR3443##or a pharmaceutically acceptable salt thereof, whereinR.sub.1 is phenyl, unsubstituted or substituted with loweralkyl;R.sub.2 is --C(W)N(R)--C(R.sub.14)(R.sub.v)--C(O)OR.sub.15, whereinW is O or S,R is hydrogen or loweralkyl,R.sub.14 is unsubstituted thioalkoxyalkyl,R.sub.v is hydrogen, andR.sub.15 is hydrogen or loweralkyl; or--L.sub.11 --C(R.sub.14)(R.sub.v)--C(O)OR.sub.15, wherein L.sub.11 is a covalent bond,R.sub.v is hydrogen,R.sub.14 is unsubstituted thioalkoxyalkyl,R.sub.15 is hydrogen or loweralkyl;L.sub.1 is methylene;Z is a covalent bond;R.sub.3 is pyrrolidin-1-yl wherein the pyrrolidinyl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of(a) alkanoyl,(b) alkoxy wherein the alkoxy is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting ofhalogen,aryl, andcycloalkyl,(c) alkoxyalkyl wherein the alkoxyalkyl is unsubstituted or substituted with 1 or 2, 3, 4 or 5 substituents independently selected from the group consisting ofaryl andcycloalkyl,(d) alkoxycarbonyl wherein the alkoxycarbonyl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting ofaryl and cycloalkyl,(e) alkylsilyloxyalkyl,(f) arylalkyl,(g) aryl wherein the aryl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting ofalkanoyl,alkoxy wherein the alkoxy is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of cycloalkyl,carboxaldehyde,haloalkyl,halogen,loweralkyl,nitro,--NRR', andthioalkoxy,(h) arylalkyl,(i) aryloxy wherein the aryloxy is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of,halogen,nitro, and--NRR',(j) (aryl)oyl,(k) carboxaldehyde,(l) carboxy,(m) carboxyalkyl,(n) --C(O)NRR"" wherein R is defined previously and R"" is selected from the group consisting ofhydrogen,loweralkyl, andcarboxyalkyl,(o) cyano,(p) cyanoalkyl,(q) cycloalkyl,(r) cycloalkylalkyl,(s) cycloalkoxyalkyl,(t) halogen,(u) haloalkyl wherein the haloalkyl is unsubstituted or substituted with 1, 2, 3, 4, or 5 hydroxyl substituents,with the proviso that no two hydroxyls are attached to the same carbon,(v) heterocycle,(w) hydroxyl,(x) hydroxyalkyl wherein the hydroxyalkyl is unsubstituted or substituted with substitutients selected from the group consisting of aryl,(y) loweralkyl wherein the loweralkyl is unsubstituted or substituted with substituents selected from the group consisting ofheterocycle,hydroxyl,with the proviso that no two hydroxyls are attached to the same carbon, and--NR.sup.R3 R.sup.R3',(z) nitro,(aa) --NRR',(bb) oxo,(cc) --SO.sub.2 NR.sub.A' R.sub.B' wherein R.sub.A' and R.sub.B' are independently selected from the group consisting ofhydrogen,(aryl)oyl,loweralkyl, andheterocycle wherein the heterocycle is unsubstituted or substituted with 1, 2, or 3 substituents independently selected from the group consisting of loweralkyl, andR.sub.4 is hydrogen.