Patent ID: 7820453
Filing Date: 2010-10-26
Classification: G01N

Abstract:
1. An assay for screening test compounds, comprising: a) incubating a source containing a HERG polypeptide comprising SEQ ID NO: 2 with: i) radiolabeled astemizole of formula (III) b) incubating the source containing a HERG polypeptide comprising SEQ ID NO: 2 and the radiolabeled astemizole of formula III with: ii) the test compound; c) measuring the amount of radiolabeled astemizole bound to the HERG polypeptide in step a); d) measuring the amount of radiolabeled astemizole bound to the HERG polypeptide in step b); e) comparing the amount of radiolabeled astemizole bound to the HERG polypeptide measured in step a) with the amount of radiolabeled astemizole bound to the HERG polypeptide measured in step b);