Patent ID: 7189722
Filing Date: 2007-03-13
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: B is a selected from the group consisting of: C where B is linked to A where B is unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from R R A 1 and A 2 are independently selected from: (1) a bond, (2) —CR (3) NR (4) —CR (5) —CR (6) —CH (7) —O—CR (8) —CR (9) —C≡C—, or wherein one of A X selected from —CO— and —SO 2 —; R 4 is selected from: (1) hydrogen, (2) C (3) C (4) benzyl, and (5) phenyl; R 5a , R 5b and R 5c are independently selected from: (1) hydrogen, (2) C (3) —O—C (4) —OCF (5) trifluoromethyl, (6) halo, (7) hydroxy, and (8) —CN; R 6 is selected from: (1) hydrogen, (2) —C (3) phenyl or heterocycle, wherein heterocycle is selected from: pyridyl, pyrimidinyl, pyrazinyl, thienyl, or morpholinyl, which is unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from: m is 1 or 2; n is 1 or 2; and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof.