Patent ID: 7790168
Filing Date: 2010-09-07
Classification: A61K,A61P,C07H,C12N

Abstract:
1. A method for generating an immune response in a patient, such method comprising administering to the patient an immunostimulatory oligonucleotide compound, comprising an immunostimulatory dinucleotide of formula C*pG, wherein the immunostimulatory oligonucleotide compound is at least 6 nucleotides in length, wherein C* is a non-natural pyrimidine nucleoside selected from the group consisting of 5-hydroxycytosine, 5-hydroxymethylcytosine, N4-alkylcytosine-and 4-thiouracil, and G is guanosine and p is an intemucleotide linkage selected from the group consisting of phosphorothiate and phosphorodithioate.