Patent ID: 7951924
Filing Date: 2011-05-31
Classification: A61K,C07K,C12N

Abstract:
1. An isolated polynucleotide comprising a nucleic acid sequence encoding a human RhoB variant polypeptide comprising an amino acid sequence having at least one point mutation relative to the human wild-type RhoB polypeptide, wherein the human wild-type RhoB polypetide comprises the amino acid sequence of SEQ ID NO:54, and wherein said human RhoB variant polypeptide exhibits inhibition of TGF-βII receptor promoter transcriptional activity characteristic of human wild-type RhoB polypeptide, and wherein said at least one point mutation is at an amino acid position in the human wild-type RhoB polypeptide selected from the group consisting of 29, 100, 116, 123, 127, 129, 143, 141, 146, 149, 152, 154, 155, 173, 181, 187, 190, and 191.