Patent ID: 8530698
Filing Date: 2013-09-10
Classification: B01D,B01J

Abstract:
1. A packing material for liquid chromatography comprising a base matrix, a ligand immobilized directly to the base matrix and a ligand immobilized to the base matrix via a spacer, wherein (1) the base matrix is a hydrophilic base matrix having alcoholic hydroxy groups on its surface, (2) the spacer is a synthetic polymer having alcoholic hydroxy groups, or a polysaccharide, (3) the ligand is an α-amino acid represented by the following formula (1): wherein R is an aromatic group, an iso-butyl group, a n-butyl group, a C 5-7 non-ionic aliphatic group, or an aminomethyl benzoic acid, or the ligand is a mixture of α-amino acids represented by the above-formula (1), (4) the ligand immobilized directly to the base matrix, is immobilized to the base matrix by an amide bond or an urethane bond via the amino group contained in the compound represented by the formula (1), (5) the ligand immobilized to the base matrix via a spacer, is immobilized to the spacer by an amide bond or an urethane bond via the amino group contained in the compound represented by the formula (1), and (6) the amount of the ligand immobilized to the base matrix is at least 30 mmol per liter (wet volume) of the packing material for liquid chromatography.