Patent ID: 6583311
Filing Date: 2003-06-24
Classification: A61L,A61P,C07C

Abstract:
A compound containing at least one stabilized S-nitrosyl group and at least one free thiol group or free alcohol group, wherein the S-nitrosyl group is stabilized by the free alcohol group or the free thiol group and wherein the compound has a half-life for NO-release that is at least two times as great as the corresponding compound without the free thiol group or free alcohol group, wherein the compound is prepared by reacting a polythiol or a thioalcohol with a nitrosylating agent, with the proviso that the polythiol or thioalcohol is not a polypeptide, an unsubstituted straight chained or branched dithiolated alkane, an unsubstituted straight chained or branched thiolalkanol, a polythiolated polysaccharide, or a polymer with pendant thiol groups and is not represented by one of the following structural formulas: wherein each Ra is â€”H or methyl and is independently chosen.