Patent ID: 6043257
Filing Date: 2000-03-28
Classification: C07D

Abstract:
A compound of formula I: ##STR54## or stereoisomer or pharmaceutically acceptable salt form thereof wherein: W and W.sup.3 are CH;W.sup.1 and W.sup.2 are selected from C and CH;one of D and D.sup.a is selected from CN, C(.dbd.NR.sup.7)NR.sup.8 R.sup.9, NHC(.dbd.NR.sup.7)NR.sup.8 R.sup.9, NR.sup.8 CH(.dbd.NR.sup.7), C(O)NR.sup.8 R.sup.9, and (CH.sub.2).sub.t NR.sup.8 R.sup.9, and the other is absent;one of J.sup.a and J.sup.b is substituted by --(CH.sub.2).sub.n --Z--A--B;J, J.sup.a, and J.sup.b combine to form pyrazole substituted with 0-2 R.sup.1 ;R.sup.1 is selected from H, C.sub.1-4 alkyl, (CH.sub.2).sub.r OR.sup.3, (CH.sub.2).sub.r NR.sup.3 R.sup.3', (CH.sub.2).sub.r C(.dbd.O)R.sup.2, (CH.sub.2).sub.r (CH.dbd.CH)(CH.sub.2).sub.r C(.dbd.O)R.sup.2, (CH.sub.2).sub.r NR.sup.3 C(O)R.sup.2, (CH.sub.2).sub.r SO.sub.2 R.sup.4, (CH.sub.2).sub.r NR.sup.3 SO.sub.2 R.sup.4, and (CH.sub.2).sub.r -5-membered heterocyclic group having 1-4 heteroatoms selected from N, O, and S;R.sup.2 is selected from H, OR.sup.3, C.sub.1-4 alkyl, NR.sup.3 R.sup.3', CF.sub.3, and C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6 ;R.sup.3 and R.sup.3' are independently selected from H, C.sub.1-4 alkyl, and C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6 ;R.sup.4 is selected from C.sub.1-4 alkyl, NR.sup.3 R.sup.3', and C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6 ;Z is selected from CH.dbd.CH, CH((CH.sub.2).sub.m Q(CH.sub.2).sub.m R.sup.5), CH((CH.sub.2).sub.m Q(CH.sub.2).sub.m R.sup.5)C(O)NR.sup.3, CH((CH.sub.2).sub.m C(O)(CH.sub.2).sub.m R.sup.5a), N((CH.sub.2).sub.q Q(CH.sub.2).sub.m R.sup.5), N(Q'(CH.sub.2).sub.m R.sup.5), C(O)N((CH.sub.2).sub.m Q'(CH.sub.2).sub.m R.sup.5a), C(O)(CH.sub.2).sub.r, C(O)O(CH.sub.2).sub.r, OC(O)(CH.sub.2).sub.r, C(O)(CH.sub.2).sub.r NR.sup.3 (CH.sub.2).sub.r, NR.sup.3 C(O)(CH.sub.2).sub.r, OC(O)NR.sup.3 (CH.sub.2).sub.r, NR.sup.3 C(O)O(CH.sub.2).sub.r, NR.sup.3 C(O)NR.sup.3 (CH.sub.2).sub.r, S(O).sub.p (CH.sub.2).sub.r, SO.sub.2 CH.sub.2, SCH.sub.2 C(O)NR.sup.3, SO.sub.2 NR.sup.3 (CH.sub.2).sub.r, NR.sup.3 SO.sub.2 (CH.sub.2).sub.r, and NR.sup.3 SO.sub.2 NR.sup.3 (CH.sub.2).sub.r ;Q is selected from a bond, O, NR.sup.3, C(O), C(O)NR.sup.3, NR.sup.3 C(O), SO.sub.2, NR.sup.3 SO.sub.2, and SO.sub.2 NR.sup.3 ;Q' is selected from a bond, C(O), C(O)NR.sup.3, SO.sub.2, and SO.sub.2 NR.sup.3 ;R.sup.5 is selected from H, C.sub.1-4 alkyl, C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6, and 5-10 membered heterocyclic group containing from 1-3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R.sup.6, provided that when Q is SO.sub.2 or NR.sup.3 SO.sub.2, R.sup.5 is other than H and when Q' is SO.sub.2, R.sup.5 is other than H;R.sup.5a is selected from NHR.sup.5, OR.sup.5, and R.sup.5 ;A is pyridine substituted with 0-2 R.sup.6 ;B is selected from:X--Y, C.sub.3-6 alkyl, NR.sup.3 R.sup.3', C(.dbd.NR.sup.3)NR.sup.3 R.sup.3', NR.sup.3 C(.dbd.NR.sup.3)NR.sup.3 R.sup.3',benzyl substituted with 0-2 R.sup.6,C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6, and- 10membered heterocyclic group containing from 1-3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R.sup.6 ;X is selected from C.sub.1-4 alkylene, --C(O)--, --C(O)CR.sup.3 R.sup.3' --, --CR.sup.3 R.sup.3' C(O), --S(O).sub.p --, --S(O).sub.p CR.sup.3 R.sup.3' --, --CR.sup.3 R.sup.3' S(O).sub.p --, --S(O).sub.2 NR.sup.3 --, --NR.sup.3 S(O).sub.2 --, --C(O)NR.sup.3 --, --NR.sup.3 C(O)--, --NR.sup.3 --, --NR.sup.3 CR.sup.3 R.sup.3' --, --CR.sup.3 R.sup.3' NR.sup.3 --, O, --CR.sup.3 R.sup.3' O--, and --OCR.sup.3 R.sup.3' --;Y is selected from:C.sub.3-10 carbocyclic group substituted with 0-2 R.sup.6, and- 10membered heterocyclic group containing from 1-3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R.sup.6 ;R.sup.6 is selected from H, OH, (CH.sub.2).sub.n OR.sup.3, halo, C.sub.1-4 alkyl, CN, NO.sub.2, (CH.sub.2).sub.r NR.sup.3 R.sup.3', (CH.sub.2).sub.r C(O)R.sup.3, NR.sup.3 C(O)R.sup.3', NR.sup.3 C(O)NR.sup.3 R.sup.3', CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2 NR.sup.3 R.sup.3', CONHSO.sub.2 R.sup.4, NR.sup.3 SO.sub.2 NR.sup.3 R.sup..sup.3', NR.sup.3 SO.sub.2 --C.sub.1-4 alkyl, and (C.sub.1-4 alkyl)-tetrazolyl;R.sup.7 is selected from H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxy, C.sub.1-4 alkoxycarbonyl, C.sub.6-10 aryloxy, C.sub.6-10 aryloxycarbonyl, C.sub.6-10 arylmethylcarbonyl, C.sub.1-4 alkylcarbonyloxy C.sub.1-4 alkoxycarbonyl, C.sub.6-10 arylcarbonyloxy C.sub.1-4 alkoxycarbonyl, C.sub.1-6 alkylaminocarbonyl, phenylaminocarbonyl, and phenyl C.sub.1-4 alkoxycarbonyl;R.sup.8 is selected from H, C.sub.1-6 alkyl and (CH.sub.2).sub.n -phenyl;R.sup.9 is selected from H, C.sub.1-6 alkyl and (CH.sub.2).sub.n -phenyl;n is selected from 0, 1, 2, 3, and 4;m is selected from 0, 1, and 2;p is selected from 0, 1, and 2;q is selected from 1 and 2; and,r is selected from 0, 1, 2, 3, and 4;provided that:(a) Z is other than CH.sub.2 ; and,(b) if Z is CH((CH.sub.2).sub.m Q(CH.sub.2).sub.m R.sup.5) or CH((CH.sub.2).sub.m C(O)(CH.sub.2).sub.m R.sup.5a), then B is other than X--Y, a C.sub.3-10 carbocyclic group or a 5-10 membered heterocyclic group;(c) R.sup.5, B, and Y are other than piperazine and piperidine.