Patent ID: 6407112
Filing Date: 2002-06-18
Classification: C07D

Abstract:
An optically active compound represented by the following formula (I): wherein D represents the following formula (IIIa), (IV) or (VI): R1 and R3 each independently represents (single or plural) a hydrogen atom, a halogen atom, a lower alkyl, a cyano, a trihalomethyl, a hydroxy, an alkoxy, an alkylthio, an alkylsulfinyl, an alkylsulfonyl, a carboxy, an alkoxycarbonyl, an acyl, an acyloxy, an acylthio, a sulfamoyl, a nitro, an amino, an alkylamino, a cabamoyl, an alkylcarbamoyl or a phenyl; R2 represents a hydrogen atom, a lower alkyl or an aralkyl; n represents an integer of 2 to 4; A represents N, CH, C having a double bond or CR7, in which R7 represents a lower alkyl, a cyano, a carbamoyl, an alkylcarbamoyl, a carboxy, an acyl, an acyloxy, an alkoxy, an alkoxycarbonyl, a trihalomethyl or a hydroxy;  represents a single bond or a double bond; E2 represents a group forming a benzene ring, a pyridine ring or a pyrimidine ring together with a carbon atom having a double bond in a condensed part; J represents a group forming a benzene ring, a thiophene ring, a furan ring, an imidazole ring or a pyrazole ring together with a carbon atom having a double bond in a condensed part; X represents NR8, NCONR9R10, S, SO, SO2, or O, in which R8 represents a hydrogen atom, a lower alkyl, an aralkyl, an oxoalkyl, an alkenyl, a cyanoalkyl, a hydroxyalkyl, an alkoxyalkyl, an aminoalkyl, an alkylaminoalkyl, an alkoxycarbonylalkyl, a carbamoylalkyl, an alkylcarbamoylalkyl, an acyl or an alkoxycarbonyl, R9 and R10 each independently represents a hydrogen atom or a lower alkyl; Y represents CH2, S, O or CO; Ra represents a hydrogen atom or an alkyl; m represents an integer of 1 to 3; p represents an integer of 0 or 1 to 3; q represents an integer of 0 or 1 to 3, provided that p+q represents an integer of 1 to 3; or the pharmacologically acceptable salt thereof.