Patent ID: 6713260
Filing Date: 2004-03-30
Classification: G01N,Y10S,Y10T

Abstract:
A system for determining whether a test compound is capable of binding a target species under isothermal denaturing conditions, comprising:(a) a compartment comprising a mixture comprising; (i) at least one test compound; and (ii) a least one target species, wherein the isothermal denaturing conditions are effective to cause at least a portion of the target species to denature to a measurable extent; (b) means for providing isothermal denaturing conditions; and (c) means for detecting a denaturation signal of each target species in the presence of at least one test compound, whereby a decrease in the denaturation signal of the target species in the presence of the at least one test compound as compared to a denaturation signal of the species in the absence of the at least one test compound is an indication of binding between the target species and the at least one test compound.