Patent ID: 6120776
Filing Date: 2000-09-19
Classification: A61K,C07K

Abstract:
A kit comprising:(A) a BCG vaccine against tuberculosis, and(B) at least one diagnostic test comprising a pharmaceutical composition comprising a polypeptide, wherein:(i) the polypeptide has a length of at least 12 amino acid residues, and the polypeptide has a sequence comprising at least 12 amino acid residues from a polypeptide of a mycobacterium of the tuberculosis complex (Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis), and(ii) lymphoid cells previously primed with virulent mycobacteria belonging to the tuberculosis complex (Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis) are capable of reacting with the polypeptide and(iii) lymphoid cells previously primed with a vaccine against tuberculosis are not capable of reacting with the polypeptide, and(iv) a positive response is indicative of having or having had tuberculosis, and(v) a negative response is indicative of not having or not having had tuberculosis.