Patent ID: 8546092
Filing Date: 2013-10-01
Classification: G01N,Y10T

Abstract:
1. A method for detecting resistance to antiplatelet drugs in a patient diagnosed with or at risk for acute coronary syndrome (ACS) comprising: obtaining a platelet sample from the patient, wherein the patient is taking one or more antiplatelet drugs; dividing the platelet sample into a first portion of platelets and a second portion of platelets; contacting noble metal containing nanoparticles to the first portion of platelets; contacting the first and second portion of platelets with a labeled anti-CD62P antibody; measuring the expression of CD62P in the first portion of platelets; measuring the expression of CD62P in the second portion of platelets; and comparing the level of CD62P expression in the first portion of platelets to the level of CD62P expression in the second portion of platelets; and determining the patient's resistance to antiplatelet drugs, wherein a substantially higher level of CD62P expression in the first portion of platelets indicates that the subject is not resistant to the antiplatelet drug.