Patent ID: 6797694
Filing Date: 2004-09-28
Classification: A61K,A61P,Y02A

Abstract:
A method for inhibiting T cell proliferation,said method comprising administering a therapeutically effective amount of a chemical compound having selective IKCa modulatory activity to said mammal, wherein the chemical compound is a triaryl methane derivative represented by Formula VIII or a pharmaceutically acceptable salt or an oxide or a hydrate thereof, whereinn is 0; Ar1 represents a phenyl, furanyl, imidazolyl, oxazolyl, piperidyl, pyridyl, pyrimidinyl, pyrrolyl, thiazolyl or thienyl group, which group may optionally be substituted one or more times with substituents selected from the group consisting of halogen, trihalogenmethyl, alkyl, cycloalkyl, amino, nitro and cyano; and R represents â€”ORâ€², â€”C(O)Râ€², â€”C(O)ORâ€², â€”C(O)NRâ€²2 or â€”CH2ORâ€², wherein Râ€² represents hydrogen, alkyl or cycloalkyl.