Patent ID: 6340761
Filing Date: 2002-01-22
Classification: A61P,C07C,C07D

Abstract:
A process for preparing a compound of the formula whereinW represents â€”C(&boxH;O)â€” or â€”CH(OH)â€”; R1 represents hydrogen or hydroxy; R2 represents hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is â€”COOH or â€”COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0,comprising using an intermediate compound of the formula whereinHal is Cl, Br or I; n is an integer of from 1 to 5; and A is a hydrogen or hydroxy.