Patent ID: 7297795
Filing Date: 2007-11-20
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising: a. combining an amine compound with cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; b. condensing the cyanoacetamide of step a with an aniline, an alcoholic solvent, and a trialkylorthoformate to yield 3-amino-2-cyanoacrylamide; and c. combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile.