Patent ID: 7005440
Filing Date: 2006-02-28
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula I wherein: is quinoxalinyl, quinazolinyl, benzoxazolyl, benzimidazolyl, benzothiazolyl, benzofuranyl, benzothiophenyl, oxazolyl, thiazolyl, oxadiazolyl, isoxazolyl, imidazolyl, pyrazolyl, thiadiazolyl, triazolyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl, which is optionally substituted by one or more ring system substituents; and are, independently, aryl, which are optionally substituted by one or more ring system substituents; A is —O—, —S—, —SO—, —SO B is —O—, —S—, —SO—, —SO D is —O—, —S—, —NR —C(O)N(R E is a chemical bond or an ethylene group; a is 0–4; b is 0–4; c is 0–4; d is 0–5; e is 0–4; f is 0–6; g is 1–4; h is 1–4; R R q is 0–3; X is hydrogen, halogen, alkyl, alkenyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aralkoxy, heteroaralkoxy, carboxyl, alkoxycarbonyl, tetrazolyl, acyl, acylHNSO Y Y Z is R R R R or R 14 , and R 15 taken together with the carbon and nitrogen atoms through which they are linked form a 5 or 6-membered azaheterocyclyl group; and R a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof; wherein “alkyl,” when used to designate an alkyl group per se or when used as an alkyl component of any other group, is an aliphatic hydrocarbon group which is straight or branched having 1 to about 20 carbon atoms and is optionally substituted by one or more alkyl group substituents; “aryl” is an aromatic monocyclic or multicyclic ring system of about 6 to about 14 carbon atoms, which is optionally substituted by one or more ring system substituents; “heteroaryl” is an aromatic monocyclic or multicyclic ring system of about 5 to about 14 carbon atoms, in which at least one of the carbon atoms in the ring system is replaced by nitrogen, oxygen or sulfur, which is optionally substituted by one or more ring system substituents; “heterocyclyl” is a non-aromatic saturated monocyclic or multicyclic ring system of 3 to about 10 carbon atoms, in which at least one of the carbon atoms in the ring system is replaced by nitrogen, oxygen or sulfur, which is optionally substituted by one or more ring system substituents; “heteroaralkyl” is a heteroaryl-alkyl group, wherein the heteroaryl and alkyl groups are as defined above; an “alkyl group substituent” is halo, carboxy, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, alkoxy, alkoxycarbonyl, aralkoxycarbonyl, heteroaralkoxycarbonyl, or Y a “ring system substituent” is alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, fused cycloalkyl, fused cycloalkenyl, fused heterocyclyl, fused heterocyclenyl, arylazo, heteroarylazo, R wherein the substituents may contain further alkyl group substituents or ring system substituents as recited herein.