Patent ID: 8735354
Filing Date: 2014-05-27
Classification: A61K,A61L,A61P,C07K,D06M

Abstract:
1. A peptide amphiphile, comprising a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophilic peptide sequence comprises a degradation sequence and one or more of a first cell adhesive sequence and a nitric oxide producing donor sequence; wherein the first adhesive sequence is an endothelial cell adhesive sequence; wherein the cell adhesive sequence comprises YIGSR (SEQ ID NO: 2), RGD (SEQ ID NO: 8), RGDS (SEQ ID NO: 9), DGEA (SEQ ID NO: 10), VAPG (SEQ ID NO: 11), REDV (SEQ ID NO: 12), or LRSR (SEQ ID NO: 14); wherein the degradation sequence comprises a matrix metalloprotease (MMP) specific cleavage site; and wherein the nitric oxide producing sequence comprises polylysine, polycysteine sequence, or modified polylysine.