Patent ID: 6835549
Filing Date: 2004-12-28
Classification: A61B,A61K,G01N

Abstract:
An in vitro immunoassay method for diagnosing human colonic type gastric intestinal metaplasia which comprises the steps of:(a) contacting a gastric tissue sample of a subject suspected of having human colonic type gastric intestinal metaplasia cells with a monoclonal antibody DAS-1, or a fragment thereof, wherein the monoclonal antibody is produced by a hybridoma deposited under ATCC accession number HB 9397 and reacts with a human gastric intestinal metaplasia antigen, wherein the antigen is a colon epithelial specific protein and wherein the gastric tissue sample is not a gastric cardia; and (b) detecting immunoreactivity between the gastric tissue sample and the monoclonal antibody, such immunoreactivity indicating a positive diagnosis of human colonic type gastric intestinal metaplasia.