Patent ID: 9216192
Filing Date: 2015-12-22
Classification: A61K,A61P,B82Y,C07D,C08B,Y02A

Abstract:
1. A stable liquid formulation comprising a Toll-like receptor (TLR) agonist and a β-cyclodextrin, wherein said agonist is (1E,4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide or a pharmaceutically acceptable salt thereof, and the formulation is an aqueous solution comprising the agonist at a concentration of from about 1 mg/ml to about 40 mg/ml and the β-cyclodextrin at a concentration of from about 1% to about 30% weight/volume, and the pH of the formulation is from about 5.0 to about 7.