Patent ID: 9073992
Filing Date: 2015-07-07
Classification: A61K,A61P,C07K

Abstract:
1. An isolated human monoclonal or recombinant antibody or fragment thereof that binds to the TSH receptor, wherein the antibody or fragment thereof reduces TSH ligand-induced stimulation of production of cAMP by the TSH receptor relative to TSH ligand-induced stimulation of production of cAMP by the TSH receptor in the absence of the antibody or fragment thereof but wherein the antibody or fragment thereof has no effect on constitutive activity of the TSH receptor, wherein the antibody or fragment thereof, at 1 μg/ml, inhibits greater than 90% of 125 I-TSH binding to TSHR, TSH-biotin binding to TSHR, and TSH-mediated stimulation of cAMP production in CHO cells expressing TSHR, wherein the antibody or fragment thereof comprises an antibody variable region heavy chain (VH) domain comprising the amino acid sequence shown in residues 1-138 in SEQ ID NO:51 and an antibody variable region light chain (VL) domain comprising the amino acid sequence shown in residues 1-130 of SEQ ID NO:69.