Patent ID: 6046180
Filing Date: 2000-04-04
Classification: A61K,A61P,C07F

Abstract:
A compound of formula I: ##STR38## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl group, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.1 ;X is CH.sub.2 or O; andR.sub.2 is C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl group, C.sub.3 -C.sub.8, cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, phenyl or naphthyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl groups may be optionally substituted with C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 or C.sub.5 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkenyl, halo, hydroxyl, nitro, trifluorornethyl, C.sub.1 -C.sub.6 straight or branched chain alkyl or alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkenyloxy, phenoxy, benzyloxy, or Ar.sub.1, and where Ar.sub.1 is selected from the group consisting of 1-neaphihyl, 2-naphthyl, or phenyl, having one to five substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 straight or branched alkyl or alkenyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkenyloxy, phenoxy, and benzoyloxy provided that R.sub.2 may not be substituted when phenyl or naphthyl; or a pharmaceutically acceptable salt, hydrate, or mixture thereof.