Patent ID: 6080393
Filing Date: 2000-06-27
Classification: A61K,A61Q,Y10S

Abstract:
A skin care composition comprising an oil-in-water emulsion and a therapeutically effective amount of a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, said composition having a pH of between about 4 and about 10; said composition further comprising an oil phase, said oil phase comprising one or more oils having a total unsaturation density, or C value, of about 1200 or less, wherein C is calculated as follows:C=A.times.B,wherein A is the percentage of an oil or fat in said composition and B is the iodine value of said oil or fat; said composition further comprising a stabilized system selected from the group consisting of:a) a stabilizing effective amount of at least one oil-soluble antioxidant present in said oil-phase of said emulsion;b) a stabilizing effective amount of a chelating agent present in the water phase of said emulsion and at least one oil-soluble antioxidant present in said oil phase of said emulsion;c) a stabilizing effective amount of a chelating agent present in said water phase of said emulsion; andd) a stabilizing effective amount of a chelating agent and an antioxidant present in each of the oil and water phases of said emulsion;wherein said composition comprises less than about 12% by weight of a volatile silicone and said water-soluble antioxidant is selected from the group consisting of ascorbic acid, sodium sulfite, sodium bisulfite, sodium thiosulfite, sodium formaldehyde sulfoxylate, isoascorbic acid, thioglycerol, thiosorbitol, thiourea, thioglycolic acid, cysteine hyrochloride, 1,4-diazobicyclo-(2,2,2)-octane, and mixtures thereof; said composition retaining at least about 70% of said retinoids after 13 weeks' storage at 40.degree. C.