Patent ID: 6235787
Filing Date: 2001-05-22
Classification: A61P,C07C,C07D,Y10S

Abstract:
Compounds of the general formula: ##STR9##whereinY is CO or SO.sub.2 ;R.sup.1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl;R.sup.2 is lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl or aryl when Y is SO.sub.2 and is lower alkyl, halo-lower alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, lower cycloalkyl, aryl, aryl-lower alkyl, aryl-lower alkoxy or NR.sup.5 R.sup.6 when Y is CO; andR.sup.3 is hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl or heterocyclyl; orR.sup.2 and R.sup.3 together form the residue of a 5-, 6- or 7-membered cyclic amide, cyclic imide, cyclic sulphonamide or cyclic urethane group;R.sup.4 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a group of the formula X-aryl, X-heteroaryl or --(CH.sub.2).sub.1-2 --CH.dbd.CR.sup.7 R.sup.8 ;X is a spacer group;R.sup.5 and R.sup.6 each individually are hydrogen, lower alkyl or aryl-lower alkyl; andR.sup.7 and R.sup.8 together represent a lower alkylene group in which one methylene group is optionally replaced by a hetero atom;and pharmaceutically acceptable salts thereof.