Patent ID: 6395255
Filing Date: 2002-05-28
Classification: A61K

Abstract:
A composition having formula I or III :M-Z-X1-P-X2â€ƒâ€ƒ(I) X1-P-X2-Z-Mâ€ƒâ€ƒ(II) wherein:M is a radiolabeling moiety comprised of four amino acid(s) capable of complexing with a selected radionuclide in an N4 configuration; Z is (D)-4-aminobutyric acid; X1 is from zero to twenty natural or synthetic amino acid(s); P is a peptide comprising a sequence His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn (SEQ ID NO: 1), or an analog or fragment thereof; wherein said analog or fragment retains biological activity of SEQ.ID.NO: 1; and X2 is from zero to twenty natural or synthetic amino acid(s).