Patent ID: 6726919
Filing Date: 2004-04-27
Classification: A61K,A61P,Y02A

Abstract:
A sterile, injectable dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising:propofol in an amount of from about 1% to about 7.5% by weight/volume of the dispersion, a propofol-soluble diluent in an amount of from about 1% to about 8% by weight/volume of the dispersion, and a surface stabilizing amphiphilic agent in an amount of from about 0.67% to about 5% by weight/volume of the dispersion, suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5, and the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5.