Patent ID: 7666659
Filing Date: 2010-02-23
Classification: C07C,C07D,C12P

Abstract:
1. A process for producing an optically active 3-hydroxypropionic ester derivative represented by the formula (3): where R 1 represents an alkyl group having 2 to 10 carbon atoms, an optionally substituted aralkyl group having 5 to 15 carbon atoms, or an optionally substituted aryl group having 5 to 15 carbon atoms; R 2 represents an alkyl group having 1 to 10 carbon atoms, or an optionally substituted aralkyl group having 5 to 15 carbon atoms; and * represents an asymmetric carbon atom, characterized by subjecting a 2-formylacetic ester derivative represented by the formula (2): where R 1 and R 2 are the same as described above; and X represents H, Li, Na or K, to the action of an enzymatic source capable of stereoselectively reducing the formyl group thereof, wherein the R configuration of the derivative represented by the formula (3) is produced by using an enzymatic source which is derived from a microorganism of the genus of the S configuration of the derivative represented by the formula (3) is produced by using an enzymatic source which is derived from an microorganism of the genus of recovering the optically active 3-hydroxypropionic ester derivative represented by the formula (3) after the stereoselective reduction.