Patent ID: 8084197
Filing Date: 2011-12-27
Classification: B01J,B82Y,C12Q,C40B

Abstract:
1. A method for determining whether a nucleic acid sample from a patient contains nucleic acid encoding a signature sequence characteristic of a pathogen said method comprising: obtaining a nucleic acid containing sample from said patient; providing a probe array comprising a first plurality of polynucleotide probe sets each probe set defining a different reference nucleotide sequence wherein each reference nucleotide sequence signature is between 15 and 30 bases in length and codes for a different amino acid sequence that is a signature sequence characteristic of said pathogen; and a second plurality of polynucleotide probe sets each probe set defining a degenerate set of nucleotide sequences encoding each different amino acid sequence and wherein the probe set defining said degenerate set comprises at least 25% of the nucleotide sequences encoding said degenerate set; hybridizing said nucleic acid sample to said probe array to generate a hybridization pattern; and analyzing said hybridization pattern to determine if nucleic acid encoding a sequence signature characteristic of said pathogen is present in the sample.