Patent ID: 8163501
Filing Date: 2012-04-24
Classification: C12Q,G01N

Abstract:
1. A method for determining the likelihood of being susceptible to a fibrostenotic subtype of Crohn's disease characterized by small bowel involvement in a subject having Crohn's disease, said method comprising: (a) contacting a sample obtained from the subject with an antigen or fragment thereof specifically reactive with IgA anti-I2 antibodies; and (b) measuring the level of IgA anti-I2 antibodies in said sample with an enzyme linked immunosorbent assay (ELISA) to detect specific binding of said IgA anti-I2 antibodies to said antigen or fragment thereof, wherein a high level of said IgA anti-I2 antibodies is indicative of an increased likelihood of said fibrostenotic subtype of Crohn's disease characterized by small bowel involvement.