Patent ID: 6689386
Filing Date: 2004-02-10
Classification: A61K,A61P,Y10S

Abstract:
A method of preparing an oral sustained release dosage form for gastrointestinal administration comprising the steps of wet granulating a mixture of xanthan gum, locust bean gum, an inert diluent and an insoluble ibuprofen in a ratio of xanthan gum to locust bean gum from about 1:20 to about 20:1 and in a ratio of the total weight of said ibuprofen to the combined weight of said xanthan gum and said locust bean gum from about 1:0.06 to about 1:0.4; and tableting the resulting granulate into tablets containing from about 500 to about 1000 mg of said ibuprofen, said tablets providing effective blood plasma levels of said ibuprofen and a dissolution of said ibuprofen in-vitro when measured by the USP Type II (Paddle) Method, of at least about 6 percent by weight of said ibuprofen released after about 2 hours and a t50 at about 12 to about 16 hours.