Patent ID: 7605125
Filing Date: 2009-10-20
Classification: A61K

Abstract:
1. A conjugate of formula: wherein V and V′ are the same or different and each is doxorubicin, daunorubicin, imidazoacridone, 3-nitrophthalamide or 3-aminophthalamide, B is a heteroaromatic residue comprising a subunit of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, 4-amino-1methyl-3-hydroxypyrrole-2-carboxylic acid, γ-amino-butyric acid, α,γ-diamino-butyric acid, glutamic acid 8-amino-3,6-dioxanioic acid, β-alanine, 4-amino-benzoic acid, 3-amino-benzoic acid, 2-aminothiazole-5-carboxylic acid, 4-aminothiophene-2-carboxylic acid, 5-aminobenzthiophene-2-carboxylic acid, 5-aminobenzoxazole-2-carboxylic acid, or 5-aminobenzimidazole-2-carboxylic acid, Y and Y′ are the same or different and each is a bifunctional linker comprising a group selected from the group consisting of amino, C in each repeat unit designated by n or p, Q is independently N or CR R n and p are independently 1 to 6, o is 0 or 1, and a and b are independently 0 to 1.