Patent ID: 8236775
Filing Date: 2012-08-07
Classification: A61K,A61P,C12N

Abstract:
1. An isolated siRNA comprising a sense RNA strand and an antisense RNA strand, wherein the sense and an antisense RNA strands form an RNA duplex, and wherein the sense RNA strand comprises a nucleotide sequence substantially identical to a target sequence of about 19 to about 25 contiguous nucleotides in human HIF-1 alpha mRNA, or an alternative splice form, mutant or cognate thereof, wherein said target sequence comprises a sequence selected from SEQ ID NOs: 40, 44, 56, 93, 76, 117, 122, 127, 161, 177, 180, 200, 201, 212, 222, 224, 237, 255, and 274.