Patent ID: 8541578
Filing Date: 2013-09-24
Classification: C07D

Abstract:
1. Process for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine, characterized in that the process comprises the subsequent steps a) through f): a) reacting piperazine with N-haloacetyl-2,6-xylidine in a molar ratio of piperazine to N-haloacetyl 2,6-xylidine between about1/1 and about 6/1 in an aqueous solvent in which has been dissolved in an about equimolar amount of HCl relative to the molar amount of piperazine; b) separating the solid formed in step a) from the reaction mixture by filtration to create a filtrate; c) neutralizing the filtrate; d) extracting the filtrate with a solvent which is not or only slightly miscible with the aqueous solvent mentioned in step a); e) crystallizing the N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide from the solvent mentioned in step d); and f) separating the solid obtained in step e) from the solvent mentioned in step d).