Patent ID: 6339096
Filing Date: 2002-01-15
Classification: C07D

Abstract:
A compound of the formula I: wherein:m is 0 or 1; n is 1 or 2; A is a single bond, a straight-chained or branched C1-8-alkylene group, or a C2-8-alkenylene or C2-8-alkynylene group, wherein an unsaturated group is not directly bound to the group Y; X is an oxygen or sulfur atom; Y is an oxygen or sulfur atom; R1 is a straight-chained or branched C1-6-alkyl group, a C1-4-alkenyl group, or a C1-4-alkynyl group, wherein the multiple bond is isolated from the nitrogen-carbon bond; R2 is a straight-chained or branched C1-6-alkyl group, a C1-4-alkenyl group, or a C1-4-alkynyl group, wherein the multiple bond is isolated from the nitrogen-carbon bond; or R1 and R2 together with the nitrogen atom is a 5- to 7-membered, saturated heterocyclic ring, wherein a methylene group isolated from the nitrogen atom may be replaced by an oxygen or sulfur atom or by an â€”NHâ€” or â€”N(alkyl)-group; R3 to R6, which may be identical or different, are hydrogen atoms or alkyl groups; R7 is a C3-7-cycloalkyl group, a phenyl or naphthyl group optionally substituted by one or two halogen atoms or by an alkyl, alkoxy, trifluoromethyl, or cyano group; E is an oxygen or sulfur atom, a methylene, carbonyl, or sulfinyl group; and R8 is a hydrogen atom; or E is the group â€”C(R9R10)â€”, wherein R9 is a hydrogen atom, and R10 together with the adjacent group R8 is a carbon-carbon bond, wherein, unless otherwise stated, alkyl groups contained in the groups mentioned above contain 1 to 3 carbon atoms and a halogen atom mentioned above is a fluorine, chlorine, or bromine atom, andwherein n+m is 2,or a pharmaceutically acceptable salt thereof.