Patent ID: 6268384
Filing Date: 2001-07-31
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR71##and pharmaceutically acceptable derivatives thereof, wherein:A and B are independently selected from Ar-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, or Ar-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl;Ar is selected from 2-pyridyl, 3-pyridyl, or 4-pyridyl; and whereineach Ar is optionally substituted with one to three substituents independently selected from halogen, hydroxyl, nitro, --SO.sub.3 H, trifluoromethyl, trifluoromethoxy, (C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl, O-((C.sub.1 -C.sub.6)-straight or branched alkyl), O-((C.sub.2 -C.sub.6)-straight or branched alkenyl), O-benzyl, O-phenyl, 1,2-methylenedioxy, --N(R.sup.1) (R.sup.2), carboxyl, N-(C.sub.1 -C.sub.5 -straight or branched alkyl or C.sub.2 -C.sub.5 -straight or branched alkenyl) carboxamide, N,N-di-(C.sub.2 -C.sub.5 -straight or branched alkyl or C.sub.2 -C.sub.5 -straight or branched alkenyl) carboxamide, N-(C.sub.1 -C.sub.5 straight or branched alkyl or C.sub.2 -C.sub.5 -straight or branched alkenyl) sulfonamide, N,N-di-(C.sub.1 -C.sub.5 -straight or branched alkyl or C.sub.2 -C.sub.5 -straight or branched alkenyl) sulfonamide, morpholinyl, piperidinyl, O--Z, CH.sub.2 --(CH.sub.2).sub.q --Z, O--(CH.sub.2).sub.q --Z, (CH.sub.2).sub.q --Z--O--Z, or CH.dbd.CH--Z;wherein R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, hydrogen or benzyl; or wherein R.sub.1 and R.sub.2 are taken together with the nitrogen atom to which they are bound to form a 5-7 membered heterocyclic ring;Z is selected from 2-pyridyl, 3-pyridyl, or 4-pyridyl; andq is 0, 1 or 2;X is N, O or C(R);wherein R is selected from hydrogen, (C.sub.1 -C.sub.6)-straight or branched alkyl, or (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl;wherein when X is N or C(R), Y is selected from hydrogen, Ar, (C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, (C.sub.5 -C.sub.7)-cycloalkyl-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.5 -C.sub.7)cycloalkyl-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, (C.sub.5 -C.sub.7)-cycloalkenyl-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.5 -C.sub.7)-cycloalkenyl-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, Ar-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, Ar-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, phenyl substituted(C.sub.1 -C.sub.6)-straight or branched alkyl, or phenyl substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl;when X is O, Y is a lone pair of electrons;K is selected from (C.sub.1 -C.sub.6)-straight or branched alkyl, Ar-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, Ar-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, phenyl substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, phenyl substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, or cyclohexylmethyl; wherein any one of the CH.sub.2 groups of said alkyl, alkenyl or alkynyl chains in K is optionally replaced by O, S, S(O), S(O).sub.2 or N(R);n is 0, 1 or 2;J is selected from hydrogen, (C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, Ar-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, Ar-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, phenyl substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, phenyl substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, or cyclohexylmethyl;R.sup.3 is selected from (C.sub.1 -C.sub.6)-straight or branched alkyl, Ar-substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, (C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, Ar-substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl, phenyl substituted-(C.sub.1 -C.sub.6)-straight or branched alkyl, or phenyl substituted-(C.sub.2 -C.sub.6)-straight or branched alkenyl or alkynyl;wherein any one of the CH.sub.2 groups of said alkyl, alkenyl or alkynyl chains in R.sup.3 is optionally replaced by O, S, S(O), or N(R); andwherein any one of the CH.sub.2 groups of said alkyl, alkenyl or alkynyl in R.sup.3, except the CH.sub.2 group bound to nitrogen, is optionally replaced with C(O) or S(O).sub.2.