Patent ID: 8591878
Filing Date: 2013-11-26
Classification: A61K,A61P,C07K

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2; R R R Het is a 5- to 6-membered saturated cyclic ring having 1 or 2 heteroatoms selected from the group consisting of N, O and S, wherein said ring is substituted with 0 to 3 substituents selected from the group consisting of halogen, OR R each R each Q is independently selected from the group consisting of halogen, OR each R R R or R each R Z is C ring B is selected from the group consisting of N-linked 4- to 9-membered heterocycles containing one N atom, containing 0 or 1 additional heteroatom selected from N, O and S, and substituted by 0 to 2 R each W is independently selected from the group consisting of halogen, OR M is selected from the group consisting of C ring A is selected from the group consisting of 8- to 14-membered fused carbobi- and carbotricyclic ring systems, containing 0 to 4 heteroatoms selected from N, O and S.