Patent ID: 8378145
Filing Date: 2013-02-19
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
1. A method represented by Scheme 1: wherein Z is selected from the group consisting of optionally substituted aryl, heteroaryl and alkenyl; X is selected from the group consisting of Cl, Br, I, —OS(O) R′ and R″ are selected, independently for each occurrence, from the group consisting of H, alkyl, heteroalkyl, aryl, formyl, acyl, alkoxycarbonyl, alkylaminocarbonyl, heteroaryl, aralkyl, alkoxyl, amino, trialkylsilyl, and triarylsilyl; R′ and R″, taken together, may form an optionally substituted ring consisting of 3-10 backbone atoms inclusive; said ring optionally comprising one or more heteroatoms beyond the nitrogen to which R′ and R″ are bonded; R′ and/or R″ may be covalently linked to Z; the transition metal is selected from the Group 10 metals; the base is selected from the group consisting of fluorides, hydrides, hydroxides, carbonates, phosphates, alkoxides, metal amides, and carbanions; and the ligand is selected from the group consisting of compounds represented by L: wherein R is selected independently for each occurrence from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, and —(CH R R R R R R R R M is an alkali metal or an alkali earth metal; R m is independently for each occurrence an integer in the range 0 to 8 inclusive; provided that at least one of R the ligand is achiral, or when chiral, is a single stereoisomer or a mixture of stereoisomers.