Patent ID: 8168190
Filing Date: 2012-05-01
Classification: A61K,A61P,C07K,C12N,G01N,Y02A,Y10S

Abstract:
1. An HBV core antigen particle comprising one or more capsid binding immunogens, wherein each capsid binding immunogen comprises at least one HBV capsid-binding peptide component and one immunogenic component, wherein said immunogenic component is the same for each capsid-binding immunogen, wherein said HBV capsid-binding peptide component is a peptide selected from the group consisting of SLLGRMKGA (SEQ ID NO: 6), GSLLGRMKGA (SEQ ID NO: 36), DGSLLGRMKGAA (SEQ ID NO: 37), ADGSLLGRMKGAAG (SEQ ID NO: 38), SLLGRMKG(β-A)C (SEQ ID NO: 8), RSLLGRMKGA (SEQ ID NO: 9), HRSLLGRMKGA (SEQ ID NO: 10), ALLGRMKG (SEQ ID NO: 12), MHRSLLGRMKGA (SEQ ID NO: 40), RSLLGRMKGA(β-A)C (SEQ ID NO: 11) and MHRSLLGRMKGAG(β-A)GC (SEQ ID NO: 41), and wherein said HBV capsid binding immunogen is linked to said HBV core antigen particle through said HBV capsid-binding peptide component.