Patent ID: 9119793
Filing Date: 2015-09-01
Classification: A61K

Abstract:
1. A method for increasing the bioavailability of orally administered doxycycline, the method comprising: controlling the spatial and temporal delivery of the doxycycline administered in an oral dosage form into a gastrointestinal area of a patient in need thereof, wherein the gastrointestinal area is selected from the group consisting of the stomach, duodenum of the small intestine, and a combination thereof; wherein the oral dosage form has a modified release profile and a swellable physicochemical profile or property and comprises: a first layer and a second layer, wherein the first layer comprises one or more swellable excipients selected from the group consisting of a cellulose polymer, a polycarbonate polymer, polyvinyl acetate, agar, carbomer, polycarbophil, polyethylene oxide, chitosan, and alginate; and a second layer comprising doxycycline; wherein the oral dosage form regulates the site, commencement time, duration and rate of release of doxycycline into the gastrointestinal area of the patient, and the oral dosage form exhibits t wherein the controlled temporal release in the gastrointestinal area of the patient is completed in about 2.5 hours to about 7.0 hours after administration to the patient; and wherein the increased bioavailability is 90% or greater relative to an immediate release doxycycline profile.