Patent ID: 6770438
Filing Date: 2004-08-03
Classification: A61K,A61P,C07K,C12N

Abstract:
A method of screening for preneoplastic/neoplastic disease associated with abnormal MN gene expression comprising:(a) determining whether abnormal MN gene expression is present in a vertebrate using a nucleic acid based assay on a sample from said vertebrate; and (b) if abnormal MN gene expression is determined to be present in said vertebrate, determining that said vertebrate has a significant risk of having preneoplastic/neoplastic disease; wherein said MN gene encodes an MN protein that is encoded by a nucleic acid having a nucleotide sequence selected from the group consisting of: (1) SEQ ID NO: 1; (2) nucleotide sequences that hybridize under stringent conditions to complement of SEQ ID NO: 1; and (3) nucleotide sequences that differ from SEQ ID NO: 1 or from the nucleotide sequences of (b) in codon sequence due to the degeneracy of the genetic code.