Patent ID: 7799826
Filing Date: 2010-09-21
Classification: A61K,G01N

Abstract:
1. A method of identifying a beta-lactone that inhibits tumor cell proliferation, comprising: a) contacting a sample comprising tumor cells with a beta-lactone, wherein the beta-lactone has the formula I: b) measuring the amount of cell proliferation, cell cycle progression, cell cycle arrest, or apoptosis in the sample exposed to the beta-lactone, whereby a decrease in cell proliferation, a decrease in cell cycle progression, an increase in cell cycle arrest, or an increase in apoptosis in the sample comprising tumor cells exposed to the beta-lactone, relative to the amount of proliferation, cell cycle progression, cell cycle arrest, or apoptosis in a sample comprising tumor cells not contacted with the beta-lactone, identifies a beta-lactone that inhibits proliferation of a tumor cell.