Patent ID: 9085589
Filing Date: 2015-07-21
Classification: A61P,C07D

Abstract:
1. A compound of the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, wherein W is —CH a) when W is —CH 2 —, then U is —CH 2 —, —S—, or —O—, and b) when W is —S— or —O—, then U is —CH 2 —; R with regard to R a) R 2A is an optionally substituted amino group, —SO 3 H, optionally substituted aminosulfonyl group, carboxyl group, optionally substituted (lower alkyl)oxycarbonyl group, optionally substituted carbamoyl group, hydroxyl group, or a substituted carbonyloxy group; and R 2B is a hydrogen atom, or b) R 2A and R 2B are taken together to form an optionally substituted alkenyl group, or optionally substituted oxime group, provided that when R ring A is a benzene ring, or 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; R k is an integer from 0 to 2; each R R with regard to D and E, a) D is a single bond, —N(R 8 )—, or —R 7 —N(R 8 )— wherein R 7 is an optionally substituted lower alkylene, and R 8 is a hydrogen or lower alkyl; and E is an optionally substituted quaternary ammonium group of the formula selected from the following formula (1) to (40) and (42) to (53), or b) D has the formula: wherein q is an integer of 0 or 1, and E has the formula of a quaternary ammonium group represented by the following formula (10) or (41); wherein p is an integer from 1 to 3; n is an integer of 1 or 2; R X is an optionally substituted lower alkyl; the left side of attachment binds to methylene; and the right side of attachment binds to D, provided that the case where R 1 is a phenyl and E has the formula (53) is excluded.