Patent ID: 6365610
Filing Date: 2002-04-02
Classification: A61K,A61P,C07D

Abstract:
A urokinase production inhibitor comprising as an active component an ozonide compound of formula (1) whereinA is an oxygen atom or Nâ€”R wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom; B is an oxo group or â€”R4; and a) when A is an oxygen atom, R1 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms, lower alkoxycarbonyl having 2 to 7 carbon atoms or a halogen atom, R2 is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom, R3 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom, B is an oxo group or â€”R4, R4 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, a halogen atom, lower alkanoyl having 2 to 6 carbon atoms or phenyl, and R5 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom or forms an aromatic 6-membered ring when combined with R4; or b) when A is Nâ€”R, R1 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms, or a halogen atom, R2 is a hydrogen atom or lower alkyl having 1 to 6 carbon atoms, R3 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom, B is â€”R4, wherein R4 is a hydrogen atom, phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom, and R5 is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom or forms an aromatic 6-membered ring when combined with R4.