Patent ID: 7247619
Filing Date: 2007-07-24
Classification: A61K,C07K,C12N,Y02A

Abstract:
1. A recombinant viral vector comprising: a first nucleic acid comprising a sequence encoding an exogenous polypeptide for expression in a host cell; a second nucleic acid comprising a sequence encoding a picornaviral protein 3A for expression in the host cell, wherein the picornaviral 3A protein is selected from a poliovirus 3A protein, a coxsackievirus B3 protein, and a rhinovirus 14 protein; wherein the viral vector is a recombinant retroviral vector, a recombinant adenoviral vector, a recombinant alphavirus vector, a recombinant adeno-associated viral vector, or a recombinant poxvirus vector and wherein expression of the recombinant picornaviral protein 3A results in inhibition of presentation of the exogenous polypeptide on an MHC class I molecule of the host cell.