Patent ID: 8669266
Filing Date: 2014-03-11
Classification: A61P,C07D

Abstract:
1. A compound of formula I, E is a heterocyclic residue selected from aza-bicycloheptane, aza-bicyclohexane, aza-bicyclooctane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, aziridine, decahydro-quinoline, diaza-bicyclohexane, diaza-bicycloheptane, 2,5-Diaza-bicyclo[2.2.1]heptane, 1,2-diazapane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, diaza-spirohexane, diaza-spirooctane, diaza-spiropentane, diaza-spiroheptane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, 2,3-dihydro-1H-indole, 3,4-dihydro-1H-isoquinoline, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine, dihydro-pyridazine, dihydro-oxazepine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 6,7-dihydro-4H-thiazolo[5,4-c]pyridine, 4,7-dihydro-5H-thieno[2,3-c]pyridine, 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, dioxazole, hexahydro-cyclopenta[c]pyrroline, hexahydro-pyridazine, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazoline, imidazolidine, indole, isoquinoline, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, 1,4-oxazepane, oxazepine, 1,2-oxa-thiepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolidine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydropyridine, tetrahydro-azepine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 1,2,3,4-tetrahydropyrazine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, tetrahydro-pyridazine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, 1,3,8-triaza-spiro[4.5]decane, triaza-spirooctane, triazepane, 1,2,4-triazinane and 1,3,5-triazinane, wherein said heterocyclic residue is bond by its nitrogen atom to the carbonyl carbon atom and wherein said heterocyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R7, X is selected from nitrogen atom or C—R8, Q is selected from 1) a covalent bond, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C 15) —(C 16) —(C 17) —(C J is 1) a hydrogen atom, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C 15) —(C 16) —(C Z is 1) —(C 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C A is a covalent bond, —(C B is 1) a covalent bond, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C 15) —(C 16) —(C 17) —(C 18) —(C 19) —(C 20) —(C 21) —(C R14 is halogen, —OH, ═O, —(C wherein R18 and R21 are independently from each other hydrogen atom, —(C V is —(C G is 1) a covalent bond, 2) —(C 3) —(C 4) —(C 5) —(C 6) —(C 7) —(C 8) —(C 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C 14) —(C 15) —(C 16) —(C 17) —(C 18) —(C and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, —NH M is 1) a hydrogen atom, 2) —(C 3) —C(O)—N(R11)-R12, 4) —C(O)—O—R12, 5) —(C 7) —(C 8) a 3- to 7-membered heterocyclyl, containing 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, selected from azepine, azetidine, aziridine, azirine, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, diaziridine, diazirine, dihydroimidazolone, dioxazole, dioxazine, dioxole, 1,3-dioxolene, 1,3-dioxolane, furan, imidazole, imidazoline, imidazolidine, imidazolidinone, isothiazole, isothiazolidine, isothiazoline, isoxazole, isoxazoline, isoxazolidine, morpholine, 1,2-oxa-thiepane, 1,2-oxathiolane, 1,4-oxazepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolone, oxazole, [1,3,4]oxathiazinane 3,3-dioxide, oxaziridine, oxazolidinone, oxetan, oxirane, piperazine, piperidine, pyran, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyridine, pyridinone, pyrimidine, pyrimidine-2,4-dione, pyrrole, pyrrolidine, pyrrolidinone, pyrroline, tetrahydrofuran, tetrahydropyran, tetrahydropyridine, tetrazine, tetrazole, thiadiazine thiadiazole, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazole, thiazolidine, thiazoline, thienyl, thietan, thiomorpholine, thiomorpholine 1,1-dioxide thiopyran, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, wherein said cyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, R2, R3, R4, R5, R6 and R8 are independently of one another selected from 1) a hydrogen atom, 2) —(C 3) —(C 4) halogen, 5) —(C 6) —CN or 7) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or R3 and R4, R4 and R5 or R5 and R6 are each time both —O—R10 and form together with the atoms which they are attached to a 1,3-dioxole ring or 2,3-dihydro-[1,4]dioxine ring, which is unsubstituted or substituted one, two, three or four times by R13, R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclopentyl or cyclohexyl, which is unsubstituted or substituted one, two, three or four times by R13, R7 is 1) a hydrogen atom, 2) halogen, 3) —(C 4) ═O, 5) —(C 6) —(C a) hydrogen atom, b) —(C c) —(C d) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, e) —CF f) —CHF 7) —NO 8) —CN, 9) —(C 10) —(C 11) —(C 12) —(C 13) —(C —(C 14) —(C 15) —(C 16) —(C 17) —(C 18) —(C 19) —(C 20) —(C 21) —(C 22) —(C 23) —(C 24) —(C 25) —(C 26) —(C 27) —(C 28) —(C 29) —(C 30) —(C 31) —(C 32) —(C R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) —(C 3) —(C 4) —SO 5) —(C 6) —(C 7) —O—R17, or 8) —(C R11 and R12 together with the nitrogen atom to which they are bonded form a 4- to 8-membered monocyclic heterocyclic ring, which is selected from aza-bicycloheptane, aza-bicyclohexane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, diaza-bicycloheptane, diaza-bicyclohexane, diaza-spiroheptane, diaza-spirohexane, diaza-spiropentane, diaza-spirooctane 1,2-diazapane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, dihydro-oxazepine, dihydro-pyridazine, dioxazole, hexahydro-pyridazine, imidazoline, imidazolidine, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, 1,4-oxazepane, 1,2-oxa-thiepane, oxazepine, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydro-azepine, 1,2,3,4-tetrahydropyrazine, tetrahydropyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, triazepane, 1,2,4-triazinane and 1,3,5-triazinane; wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R13 is halogen, —NO R10 and R20 are independently of one another hydrogen, —(C R15 and R16 are independently of one another hydrogen atom, —(C R17 is hydrogen atom, —(C R22 is a residue from the following list: wherein Me is methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.