Patent ID: 7713941
Filing Date: 2010-05-11
Classification: A61P,C07H

Abstract:
1. A process of making a compound having the formula: or a pharmaceutically acceptable salt thereof, comprising cyclising a compound having the formula wherein A is O, S, CH R R L is selected from the group consisting of O, S, NH, NR, CY each Y is independently selected from the group consisting of H, F, Cl, Br, alkyl, alkenyl, and alkynyl, wherein alkyl, alkenyl, and alkynyl may each optionally contain one or more heteroatoms; R dashed lines (----) indicate an optional π bond; each W each Z wherein if Z 1 , Z 2 , Z 3 and/or Z 4 is a participant in a π bond then Z 1 , Z 2 , Z 3 and/or Z 4 is independently N or C-G, and if Z 1 , Z 2 , Z 3 and/or Z 4 is not a participant in a π bond then Z 1 , Z 2 , Z 3 and/or Z 4 is independently N—(BH 2 G) − M + , O, S, NR, >C═O, >C═S, >C═NH, >C═NR, >S═O, >S(O) 2 or CH-G; (BH each G is independently selected from the group consisting of H, halogen, OH, SH, NH wherein each R is independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, acyl, and aralkyl, optionally containing one or more heteroatoms.