Patent ID: 7205308
Filing Date: 2007-04-17
Classification: A61P,C07D

Abstract:
1. A compound represented by the structural formula: or a pharmaceutically acceptable salt, ester or prodrug of said compound, wherein: R is an aryl substituted with one or more heteroaryl; R heteroaryl substituted with 0–3 aryl or heteroaryl groups which can be the same or different and are independently selected from alkyl, phenyl, pyridyl, thiophenyl, furanyl and thiazolo groups; R wherein each of said alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl and heteroarylalkyl for R 3 and the heterocyclyl moieties whose structures are shown immediately above for R 3 can be substituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF 3 , CN, —OCF 3 , —(CR 4 R 5 ) n OR 5 , —OR 5 , —NR 5 R 6 , —(CR 4 R 5 ) n NR 5 R 6 , —C(O 2 )R 5 , —C(O)R 5 , —C(O)NR 5 R 6 , —SR 6 , —S(O 2 )R 6 , —S(O 2 )NR 5 R 6 , —N(R 5 )S(O 2 )R 7 , —N(R 5 )C(O)R 7 and —N(R 5 )C(O)NR 5 R 6 ; R R R R R R R m is 0 to 4, and n is 1 to 4, with the following provisos: (i) that when R is an unsubstituted phenyl, then R 2 is not alkyl, —C(O 2 )R 6 , aryl or cycloalkyl, and (ii) that when R is a phenyl substituted with a hydroxyl group, then R 2 is halogen only.