Patent ID: 6469034
Filing Date: 2002-10-22
Classification: A61K,A61P,C07D

Abstract:
A method for inhibiting HIV reverse transriptase comprising:administering to a subject, having a strn of HIV having a mutated HIV reverse transcriptase comprising one or more of the following amino acid substitutions: K103N, V106A or Y181C, an effective therapeutic amount of at least one compound selected from; N-[2-(1-cyclohexenyl)ethyl]-Nâ€²-[2-(5-bromopyridyl)]-thiourea; N-[2-1-cyclohexenyl)ethyl]-Nâ€²-[2-(5-chloropyridyl)]-thiourea; and a pharmaceutically acceptable addition salt thereof; wherein said compound inhibits said strain of HIV reverse transcriptase.