Patent ID: 6399641
Filing Date: 2002-06-04
Classification: A61P,C07D

Abstract:
A compound of the formula whereinR1 is hydrogen, lower alkyl, â€”(CH2)nâ€”CF3, â€”(CH2)nâ€”CHF2, â€”(CH2)nâ€”CN, â€”(CH2)n-cycloalkyl, â€”(CH2)nâ€”O-lower alkyl, â€”(CH2)nâ€”O-cycloalkyl or â€”(CH2)nâ€”C(O)O-lower alkyl; R2 is hydrogen, lower alkyl, lower alkoxy, halogen, â€”C(O)-lower alkyl, â€”C(O)OH, â€”C(O)O-lower alkyl, â€”NR3R4 or â€”C(O)â€”NR3R4 and wherein R3 and R4 is hydrogen or lower alkyl; X and Xâ€² are taken together to form â€”Oâ€”, â€”Sâ€”, â€”CH2, â€”OCH2â€”, as a bridge between the two rings or individually are two hydrogen atoms not capable of forming a bridge; and n signifies 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.