Patent ID: 7928225
Filing Date: 2011-04-19
Classification: A61P,C07C,C07D

Abstract:
1. A compound selected from: (a) tert-butyl (3-{7-[2-(4-cyano-2,6-difluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (b) tert-butyl (2-{7-[2-(4-cyano-2-fluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (c) tert-butyl (3-{7-[2-(4-cyano-2-fluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (d) tert-butyl (3-{7-[3-(4-cyano-2-fluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (e) tert-butyl (3-{7-[3-(4-cyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (f) tert-butyl (2-{7-[2-(4-cyanophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)methylcarbamate; (g) tert-butyl (2-{7-[3-(4-cyanophenoxy)-2-fluoropropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (h) (3-{7-[2-(4-cyanophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-propyl)carbamic acid tert-butyl ester; (i) {3-[7-(4-cyanobenzyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}-carbamic acid tert-butyl ester; (j) tert-butyl {2-[7-(4-cyanobenzyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]ethyl}-carbamate; (k) tert-butyl[3-(7-benzyl-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)propyl]-carbamate; (l) tert-butyl (3-{7-[3-(2,4-dicyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (m) tert-butyl ((2R)-3-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-2-fluoropropyl)carbamate; (n) tert-butyl (3-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)methylcarbamate; (o) tert-butyl (3-{7-[3-(4-cyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)methylcarbamate; (p) tert-butyl (3-{7-[2-(4-cyanophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)methylcarbamate; (q) tert-butyl (2-{7-[2-(4-cyanophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)methylcarbamate; (r) tert-butyl (2-{7-[3-(4-cyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)methylcarbamate; (s) tert-butyl (3-{7-[3-(4-cyano-2,6-difluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (t) tert-butyl (2-{7-[2-(4-cyano-2,6-difluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (u) tert-butyl (2-{7-[3-(4-cyano-2,6-difluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (v) tert-butyl (2-{7-[3-(4-cyano-2-fluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (w) tert-butyl (2-{7-[(2S)-3-(4-cyano-2,6-difluorophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (x) tert-butyl (2-{7-[(2S)-3-(4-cyano-2-fluorophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (y) tert-butyl (3-{7-[2-(4-cyanophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (z) tert-butyl[2-(7-{2-[(4-cyanobenzyl)oxy]ethyl}-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]carbamate; (aa) tert-butyl (2-{7-[3-(4-cyanophenoxy)-2-fluoropropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (ab) tert-butyl (2-{7-[2-(4-cyanophenyl)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (ac) tert-butyl (2-{7-[(2S)-3-(4-cyanophenoxy)-2-methoxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (ad) tert-butyl (2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)methylcarbamate; (ae) tert-butyl[2-(7-{3-[(4-cyanophenyl)sulfonyl]propyl}-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]carbamate; (af) tert-butyl[2-(7-{2-[2-(4-cyanophenyl)ethoxy]ethyl}-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]carbamate; (ag) tert-butyl (3-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate; (ah) tert-butyl (2-{7-[3-(4-fluorophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (ai) tert-butyl (2-{7-[3-(4-chlorophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (aj) tert-butyl[2-(7-{2-[2-(4-cyanophenoxy)ethoxy]ethyl}-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]carbamate; (ak) tert-butyl (2-{7-[2-(4-bromo-2-fluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; (al) tert-butyl (2-{7-[3-(2,4-dicyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate; and (am) tert-butyl (3-{7-[3-(4-cyano-2-hydroxyphenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)carbamate, and salts thereof.