Patent ID: 6413971
Filing Date: 2002-07-02
Classification: A61P,C07D

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein:Z is a group of the formula wherein n is an integer from 0 to 2 and p is an integer from 0 to 3;R1 is H, C1-C6 alkyl or â€”C(O)(C1 C6 alkyl); R2 is 1H-indazol-5-yl, wherein said groups are optionally substituted by 1 to 3 R5 substituents, or R2 is a group of the formula (Ii) or (Ij) wherein p is an integer from 0 to 3 and n is an integer from 0 to 2;or R1 and R2 are taken together to form a group of the formula (Ik) wherein the dashed line indicates a single or double bond and m is an integer from 0 to 4;each R3 is independently H, â€”C(O)OR9, or C1-C6 alkyl wherein said alkyl is optionally substituted by halo, â€”OR9, â€”NR9R10, or â€”C(O)OR9; R4 is R3, â€”OR9, or â€”NR9R10; each R5 is independently halo, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C5 alkynyl, â€”OR9, â€”NR9R10, nitro, or C6-C10 aryl wherein said alkyl, alkenyl, alkynyl and aryl R5 groups are optionally substituted by 1 to 3 substituents independently selected from halo, nitro, C1-C4 alkyl and â€”OR9; R6 and R7 are independently H or R5; R8 is H, â€”SO2(C6-C10aryl), (CH2)q(5-10 membered heterocyclyl), C2-C6 alkenyl, C1-C6 alkyl, â€”(CH2)qO(CH2)q(C1-C6 alkoxy), â€”(CH2)q(C1-C6 alkoxy), â€”C(O)(C1-C6 alkoxy), or â€”SO2(C1-C4 alkyl) wherein each q is independently an integer from 2 to 4; each R9 and R10 is independently H or C1-C6 alkyl; and, R11 is trifluoromethyl, halo, nitro, â€”OR9, â€”NR9R10, cyano, C1-C4 alkyl, â€”S(O)xR9 wherein x is an integer from 0 to 2,â€”C(O)OR9, â€”OC(O)(C1-C4 alkyl), â€”C(O)NR9R10, â€”NR9C(O)(C1-C4 alkyl), â€”C(O)NHSO2(C1-C4 alkyl), â€”NHCH2C(O)NR9R10, â€”NHC(O)(C1-C4 alkoxy), â€”NHOC(O)(C1-C4 alkyl), â€”NR9OR10, anilino, pyrrolidinyl, piperidinyl, azido, guanidino, phenyl, â€”C(O)(C1-C6 alkyl), benzenesulfonyl, allyl, thiophenyl, morpholino, piperazinyl, 4-(C1-C4 alkyl)piperazinyl, phenylthio, benzenesulphonamido, 2-oxopyrrolidin-1-yl, 2,S-dioxopyrrolidin-1-yl, phenoxy, benzoyloxy, benzoylamino, â€”CH2)wO(CH2)vOR9, â€”O(CH2)wO(CH2)vOR9, â€”O(CH2)wC(O)OR9, â€”O(CH2)w C(O)NR9R10, â€”(CH2)wS(CH2)vOR9, â€”NH (CH2)vO(C1-C4 alkyl), â€”NH(CH2)w(C6-C10 aryl), â€”NHC(O)(CH2)w(C1-C4 alkoxy), or â€”O(CH2)w(C6-C10, aryl), wherein w is an integer from 1 to 4 and v is an integer from 2 to 4, and wherein the alkyl, heterocyclic, and aryl moieties of the foregoing R11 groups are optionally substituted by 1 or 2 substituents independently selected from the group consisting of halo, C1-C4 alkyl, â€”OR9, â€”NR9R10, â€”C(O)OR9, â€”OC(O)(C1-C4 alkyl), â€”C(O)NR9R10, â€”NHC(O)(C1-C4 alkyl), nitro, imidazolyl, piperidino, morpholino, and piperazinyl.