Patent ID: 8337878
Filing Date: 2012-12-25
Classification: A61L,A61N

Abstract:
1. An implantable or insertable medical device comprising (a) a substrate, (b) a porous layer comprising interconnected pores disposed over the substrate, (c) a first therapeutic agent disposed within the porous layer, (d) a composite layer over the porous layer that comprises (i) a therapeutic agent eluting region that comprises a second therapeutic agent and a matrix material and (ii) a plurality of bioerodible regions comprising a bioerodible material, said bioerodible material extending from the surface of the composite layer to the porous layer, wherein the therapeutic agent eluting region is disposed at the surface of the composite layer, wherein bioerosion of said bioerodible regions exposes the porous layer lying under the bioerodible regions to an exterior of the device and allows elution of the first therapeutic agent from the device, and wherein the interconnected pores of the porous layer allow diffusion of the first therapeutic agent from a region of the porous layer lying under an intact bioerodible region to a region of the porous layer that is exposed due to said bioerosion.