Patent ID: 6518316
Filing Date: 2003-02-11
Classification: A61P,C07C,C07D,C12N,C12P,C12R

Abstract:
A compound of formula (I): wherein X is &boxH;O, Nâ€”OR6, NHR or OH wherein R6 is H or C1-C6 alkyl, bond a is oriented  or  and R is H, C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, or C3-C6 cycloalkyl;  is a bond and  and  are not bonds or, when X is &boxH;O,  and  are both bonds and  is not a bond; R1 and R2, which is the same or different, are H or a halogen; R3 and R4, which are the same or different, are H, C1-C6 alkyl, C3-C6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented  or ; and R5 is C1-C6 alkyl; or formula (Ib): or formula (II): or formula (III): or a stereoisomer of a said compound; or a pharmaceutically acceptable salt or ester of a said compound or said stereoiaomer.