Patent ID: 6660736
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound of the formula whereinX is â€”N&boxH; or â€”CH&boxH;; R1 is â€”COâ€”NR5R6; â€”CHR7â€”(CH2)nâ€”COâ€”NR5R6; â€”(CH2)nâ€”NR5R6; â€”(CH2)nâ€”COOR8; â€”(CH2)nâ€”CN; â€”CHR7â€”(CH2)nâ€”CF3; â€”(CH2)nâ€”NHâ€”COR9; â€”(CH2)nâ€”NHâ€”COOR8; a heterocyclic ring-containing group selected from â€”(CH2)n-piperidinyl, â€”(CH2)n-morpholinyl, â€”(CH2)n-tetrahydrofuranyl; â€”(CH2)n-thiophenyl or â€”(CH2)n-isoxazolyl, wherein the heterocyclic ring may be substituted by C1-C6-alkyl; a phenyl; â€”(CH2)n-phenyl, wherein the phenyl ring may be substituted by halogen or halogen-(C1-C6)-alkyl; â€”(CH2)pâ€”OR8; â€”(CH2)pâ€”SR8; â€”(CH2)pâ€”SOâ€”R9; or â€”(CH2)nâ€”CSâ€”NR5R6; R2 is hydrogen; C1-C6-alkyl; â€”(CH2)pâ€”OR10; â€”(CH2)pâ€”SR10; or benzyl; R3 is hydrogen or C1-C6-alkyl; R4 is halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy; R5 and R6 are independently from each other hydrogen or C1-C6-alkyl; R7 is hydrogen, hydroxy or C1-C6-alkoxy; R8 is hydrogen or C1-C6-alkyl; R9 is C1-C6-alkyl; R10 is hydrogen or C1-C6-alkyl; m is 1, 2 or 3; n is 0, 1 or 2; and p is 1 or 2; or a pharmaceutically acceptable salt thereof.