Patent ID: 8623611
Filing Date: 2014-01-07
Classification: G01N

Abstract:
1. A method for evaluating the presence, absence, nature or extent of breast cancer or a precancerous condition of the breast, the method comprising: providing a biological sample obtained from a subject, the biological sample comprising glycoproteins; contacting the biological sample with a glycan-binding molecule specific for a glycan, under conditions that permit binding of the glycan-binding molecule to a glycoprotein comprising said glycan, wherein the glycan comprises a GlcNAc β(1,6) Man branched N-linked glycan; contacting the glycoprotein with an anti-periostin antibody; and detecting binding of the glycan-binding molecule and the anti-periostin antibody to the glycoprotein to determine the presence, absence or amount of a cancer-specific glycoform of periostin in the biological sample, wherein said cancer-specific glycoform comprises the glycan and is indicative of breast cancer or a precancerous condition of the breast; and wherein the presence, absence or amount of the cancer-specific glycoform is indicative of the presence, absence, nature or extent of breast cancer or a precancerous condition of the breast.