Patent ID: 7575898
Filing Date: 2009-08-18
Classification: C07K,C12N

Abstract:
1. A nucleic acid molecule comprising (a) a first nucleic acid sequence comprising a nucleotide sequence that encodes a fragment of a gamma-zein protein that directs a protein to and retains said protein towards the endoplasmic reticulum (ER) of a plant cell and accumulates said protein as ER-derived protein bodies, said first nucleic acid sequence consisting of a sequence that encodes a repeat domain of SEQ ID NO:17 of the gamma-zein protein and a nucleotide sequence that encodes the N-terminal nine residues to all of the ProX domain of the gamma-zein protein; and (b) a second nucleic acid sequence that encodes calcitonin as a peptide or protein of interest, wherein the 3′ end of said first nucleic acid sequence is linked to the 5′ end of said second nucleic acid sequence.