Patent ID: 6498273
Filing Date: 2002-12-24
Classification: A61K,C07C,C07D

Abstract:
A compound of the formula: wherein:R1 is selected from the group consisting of C1-C4 alkyl and C1-C4 alkyl substituted with hydroxy or C1-C4 alkoxy; R2, R3 and R4 are each independently selected from the group consisting of hydrogen and C1-C4 alkyl; R5 and R6 are each independently selected from the group consisting of hydrogen, C1-C4 alkyl and hydroxy C1-C4 alkyl, n is from 1 to 3; Z is â€”Aâ€”NHCH3 or Z is hydroxy-C2-5-alkylamino; A is: â€ƒwherein R7 is H or C1-C4 alkyl; R8 is H, C1-C4 alkyl, or C1-C4 alkyl substituted by hydroxy or C1-C4 alkoxy; or together R7 and R8 form a propylene or hydroxypropylene ring; m is O or 1; R9 and R10 are each independently H or alkyl; or R9 and R10 together form C4-C8 alkylene which is unsubstituted or substituted from one to three times with C1-C4 alkyl or hydroxy; R11 is amino or guanidino; o is from two to six; or a physiologically acceptable salt thereof.