Patent ID: 6548676
Filing Date: 2003-04-15
Classification: C07D

Abstract:
A process for the preparation of a compound of the formula or, where applicable, an E/Z-isomer, a mixture of E,Z-isomers, a tautomer and/or an acid addition product thereof, in each case in free form or in salt form, whereinR is unsubstituted or substituted C1-C12alkyl, unsubstituted or substituted C2-C4alkenyl, unsubstituted or substituted C2-C4alkynyl, unsubstituted or substituted C3-C6cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or â€”SR1; R1 is unsubstituted or substituted C1-C12alkyl, unsubstituted or substituted C2-C4alkenyl, unsubstituted or substituted C2-C4alkynyl, unsubstituted or substituted C3-C6cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; and X is a selected from halogen or a sulfonate; which comprisesreacting a compound of the formula wherein R is as defined for formula (I), or, where applicable, an E/Z-isomer, a mixture of E/Z-isomers, a tautomer and/or an acid addition product thereof, in each case in free form or in salt form, with a halogenating agent or sulfonylating agent; and if desired, separating a mixture of E/Z-isomers, obtainable in accordance with the process, and isolating the desired isomer; and/or converting a free compound of the formula (I), obtainable in accordance with the process, or, where applicable, an E/Z-isomer, a mixture of E/Z-isomers, a tautomer and/or an acid addition product thereof, into a salt; or converting a salt, obtainable in accordance with the process, or, where applicable, an E/Z-isomer, a mixture of E/Z-isomers, or a tautomer thereof, into the free compound of the formula (I) or, into a different salt.