Patent ID: 6797820
Filing Date: 2004-09-28
Classification: A61P,C07D

Abstract:
A compound of Formula (I): wherein:R1 is hydrogen, halo, â€”OH, â€”R8OR9, â€”R9, â€”OR9, â€”SH, â€”SR9, â€”NH2, â€”NHR9â€”NR9R10, â€”NHC(&boxH;O)H, â€”NR9C(&boxH;O)H, â€”NHC(&boxH;O)R9, â€”NR9C(&boxH;O)R10, â€”NHC(&boxH;O)NH2, â€”NR9C(&boxH;O)NH2, â€”NHC(&boxH;O)NHR9, â€”NHC(&boxH;O)NR9R10, â€”NR9C(&boxH;O)NR9aR10, â€”NHC(&boxH;O)OR9, â€”NR9C(&boxH;O)OR10, â€”NHS(&boxH;O)2R9, â€”NR9S(&boxH;O)2R10, â€”NHS(&boxH;O)2OR9, or â€”NR9S(&boxH;O)2OR10 where R8 is selected from the group consisting of â€”C1-C12 alkylene, substituted alkylene, or heteroalkylene, â€”C1-C12 alkenylene, substituted alkenylene, or heteroalkenylene, â€”C1-C12 alkynylene, substituted alkynylene, or heteroalkynylene, and â€”(C1-C8 alkylene or substituted alkylene)n1â€”(C3-C12 arylene or heteroarylene)-(C1-C8 alkyl or substituted alkyl)n2 where n1 and n2 are independently 0 or 1; and R9, R9a and R10 are independently selected from the group consisting of â€”C1-C12 alkyl, substituted alkyl, or heteroalkyl, â€”C1-C12 alkenyl, substituted alkenyl, or heteroalkenyl, â€”C1-C12 alkynyl, substituted alkynyl, or heteroalkynyl, and â€”(C1-C8 alkyl or substituted alkyl)n3â€”(C3-C12 arylene or heteroarylene)-(C1-C8 alkyl or substituted alkyl)n4 where n3 and n4 are independently 0 or 1; R2 is independently hydrogen or â€”R9 wherein R9 is as defined above; R3 is hydrogen, halo, â€”R11, â€”OH, â€”OR11, â€”R12OR11, â€”SH, â€”SR11, â€”NH2, â€”NHR11, â€”NR11R13, â€”NHC(&boxH;O)H, â€”NR11C(&boxH;O)H, â€”NHC(&boxH;O)R11, â€”NR11C(&boxH;O)R13, â€”NHC(&boxH;O)NH2, â€”NR11C(&boxH;O)NH2, â€”NHC(&boxH;O)NHR11, â€”NHC(&boxH;O)NR11R13, â€”NR11C(&boxH;O)NR11aR13, â€”NHC(&boxH;O)OR11, â€”NR11C(&boxH;O)OR13, â€”NHS(&boxH;O)2R13, â€”NR11S(&boxH;O)2R13, â€”NHS(&boxH;O)2OR11, or â€”NR11S(&boxH;O)2OR13, where R12 is selected from the group consisting of â€”C1-C12 alkylene, substituted alkylene, or heteroalkylene, â€”C1-C12 alkenylene, substituted alkenylene, or heteroalkenylene, â€”C1-C12 alkynylene, substituted alkynylene, or heteroalkynylene, and â€”(C1-C8 alkylene or substituted alkylene)n5â€”(C3-C12 arylene or heteroarylene)-(C1-C8 alkyl or substituted alkyl)n6 where n5 and n6 are independently 0 or 1; and R11, R11a and R13 are independently selected from the group consisting of â€”C1-C12 alkyl, substituted alkyl, or heteroalkyl, â€”C1-C12 alkenyl, substituted alkenyl, or heteroalkenyl, â€”C1-C12 alkynyl, substituted alkynyl, or heteroalkynyl, and â€”(C1-C8 alkyl or substituted alkyl)n7â€”(C3-C12 arylene or heteroaxylene)-(C1-C8 alkyl or substituted alkyl)n8 where n7 and n8 are independently 0 or 1; R4 is hydrogen or â€”R11 where â€”R11 is as defined above; R6 and R7 are each independently selected from the group consisting of hydrogen, â€”R14, â€”OH, â€”OR14, â€”SH, â€”SR14, â€”NH2, â€”NHR14, â€”NR14R15, â€”C(&boxH;O)H, â€”C(&boxH;O)R14, â€”C(&boxH;O)NH2, â€”C(&boxH;O)NHR14, â€”C(&boxH;O)NR14R15, â€”C(&boxH;O)OH, â€”C(&boxH;O)OR14, â€”C(&boxH;O)SH, â€”C(&boxH;O)SR14, â€”C(&boxH;O)CH3, â€”C(&boxH;O)CH2R14, â€”C(&boxH;O)CHR14R15, â€”C(&boxH;O)CR14R15R16, â€”C(&boxH;O)OCH3, â€”C(&boxH;O)OCH2R14, â€”C(&boxH;O)OCHR14R15, â€”C(&boxH;O)OCR14R15R16, â€”S(&boxH;O)2NH2, â€”S(&boxH;O)2NHR14, â€”S(&boxH;O)2NR14R15, â€”NHC(&boxH;O)H, â€”N(R14)C(&boxH;O)H, â€”NHC(&boxH;O)R15, â€”N(R14)C(&boxH;O)R15, â€”NHC(&boxH;O)OR14, â€”NHS(&boxH;O)2H, â€”N(R14)S(&boxH;O)2H, â€”NHS(&boxH;O)2OR15, â€”N(R14)S(&boxH;O)2OR15, â€”N(H)S(&boxH;O)2R15, â€”N(R14)S(&boxH;O)2R15 and where two vicinal R6 or R7 groups combine to form a substituted or unsubstituted â€”C4-C10 cyclic alkyl, cyclic heteroalkyl, aryl or heteroaryl group where R14, R15 and R26 are each independently selected from the group consisting of â€”C1-C12 alkyl, substituted alkyl, or heteroalkyl, â€”C1-C12 alkenyl, substituted alkenyl, or heteroalkenyl, â€”C1-C12 alkynyl, substituted alkynyl, or heteroalkynyl, alkoxy, and â€”(C1-C8 alkyl or substituted alkyl)n9â€”(C3-C12 arylene or heteroarylene)-(C1-C8 alkyl or substituted alkyl)n10 where n9 and n10 are independently 0 or 1; or when R14 and R15 are attached to a nitrogen atom they can combine to form a substituted or unsubstituted â€”C4-C10 cyclic alkyl, cyclic heteroalkyl, aryl or heteroaryl group; or a pharmaceutically acceptable salt thereof.