Patent ID: 8318810
Filing Date: 2012-11-27
Classification: A61K,A61P,B01J,B29L,B32B,C07K,C12N,G01N,Y10S

Abstract:
1. A method of treating a subject for central or peripheral nervous system damage, said damage comprising expression of a NC Ca-ATP channel in neural cells, said method comprising administering to the subject a formulation comprising an effective amount of a compound effective to inhibit the activity of a NC Ca-ATP channel in a neural cell and a pharmaceutically acceptable carrier, wherein the compound is a sulfonylurea receptor 1 (SUR1) antagonist selected from a sulfonylurea compound, a benzamido derivative, an imidazoline derivative, and a combination thereof, wherein said administration of the SUR1 antagonist inhibits the NC Ca-ATP channel in neural cells expressing the channel, wherein the subject to which the SUR1 antagonist is administered has central or peripheral nervous system damage comprising neural cell swelling, and wherein the method inhibits said neural cell swelling, thereby treating said central or peripheral nervous system damage.