Patent ID: 7772237
Filing Date: 2010-08-10
Classification: A61P,C07C,C07D

Abstract:
1. A compound of formula (A): wherein: Ar is: wherein: U is CH rings A and B are optionally substituted with one to three groups selected from F, Cl, Br, I, OR Y is C 1 -C 6 alkylene; or (C Z is O, NR 10A , S(O) y , CR 21 ═CR 21 , C≡C, C 6 -C 10 arylene, 5-10 membered heteroarylene, C 3 -C 6 cycloalkylene, or 3-6 membered heterocycloalkylene; wherein said arylene, heteroarylene, cycloalkylene, and heterocycloalkylene groups are optionally substituted with one to three R 20 groups; R 1 is selected from NR 12 R 13 , NR 21 C(═O)R 14 , C(═O)R 14 , CO 2 R 11 , OC(═O)R 11 , C(═O)NR 12 R 13 , C(═NR 11 )NR 12 R 13 , OC(═O)NR 12 R 13 , NR 21 S(O) 2 R 11 , NR 21 C(═O)NR 12 R 13 , NR 21 S(O) 2 NR 12 R 13 , and C(═O)NR 11 OR 22 ; R 10 and R 10A are each independently selected from H, C 1 -C 6 alkyl, C 6 -C 10 aryl, C(═O)R 14 , and S(O) y R 14 ; wherein said alkyl and aryl groups are optionally substituted with one to three R 20 groups; R 11 at each occurrence is independently selected from H, C 1 -C 6 alkyl, and C 6 -C 10 aryl; wherein said alkyl and aryl groups are optionally substituted with one to three R 20 groups; R 12 and R 13 at each occurrence are each independently selected from H, C 1 -C 6 alkyl, C 6 -C 10 aryl, and NR 23 R 24 , or R 12 and R 13 , together with the nitrogen to which they are attached, form a 3-7 membered heterocyclic ring; wherein said alkyl and aryl groups and heterocyclic ring are optionally substituted with one to three R R 14 at each occurrence is independently selected from C 1 -C 6 alkyl, C 6 -C 10 aryl, and alkylaryl; wherein said alkyl, aryl and alkylaryl groups are optionally substituted with one to three R 20 groups; R 20 at each occurrence is independently selected from F, Cl, Br, I, OR 22 , OR 27 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 -C 6 alkyl optionally substituted with OH, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 3-7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, arylalkyl, ═O, C(═O)R 22 , CO 2 R 22 , OC(═O)R 22 , C(═O)NR 23 R 24 , NR 21 C(═O)R 22 , NR 21 C(═O)OR 22 , OC(O)NR 23 R 24 , NR 21 C(S)R 22 , and S(O) y R 22 ; R 21 at each occurrence is independently selected from H and C 1 -C 6 alkyl; R 22 at each occurrence is independently selected from H, C 1 -C 6 alkyl optionally substituted with OH, arylalkyl and C 6 -C 10 aryl; R 23 and R 24 at each occurrence are each independently selected from H, C 1 -C 6 alkyl, and C 6 -C 10 aryl, or R 23 and R 24 , together with the nitrogen to which they are attached, form a 3-7 membered heterocyclic ring optionally substituted with ═O; R 27 at each occurrence is independently the residue of an amino acid after the hydroxyl group of the carboxyl group is removed; q is 0, 1, or 2; and y is 1 or 2; or a stereoisomeric form, mixture of stereoisomeric forms, or a pharmaceutically acceptable salt form thereof; and with the exclusion of the compounds wherein: U is CH R