Patent ID: 8497383
Filing Date: 2013-07-30
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is N—R B is N—R R R R R each X k is an integer equal to 0, 1, 2, or 3; R wherein the asterisk (*) denotes the point of attachment to the rest of the compound; each X m is an integer equal to 0, 1, 2, or 3; n is an integer equal to 0, 1, 2, or 3; R R AryA is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 4 Y AryB is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 4 Y AryC is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 4 Y HetA is a heteroaryl which is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, or (ii) is a heterobicyclic ring selected from quinolinyl, isoquinolinyl, and quinoxalinyl; wherein the heteroaromatic ring (i) or the bicyclic ring (ii) is optionally substituted with from 1 to 4 Y HetB is independently a 4- to 7-membered, saturated or unsaturated, non-aromatic heterocyclic ring containing at least one carbon atom and from 1 to 4 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O)