Patent ID: 9062121
Filing Date: 2015-06-23
Classification: A61K,A61N,A61P,C07K,C12N

Abstract:
1. A cyclic double-stranded STAT3 oligonucleotide decoy, wherein (i) the decoy comprises a double-stranded oligonucleotide, or an analog thereof, having the sequence 5′-(N 6 -) n CAN 1 TTCN 2 CN 3 TN 4 AN 5 TC-(N 7 -) m -3′ (SEQ ID NO:1), wherein N 3 is G; N 1 , N 2 , N 4 and N 5 are A, T, G or C; one, two, three or all of the following conditions are met: N 1 is T; N 1 is C; N 4 is A and N 5 is A; and N 6 and N 7 are A, T, G or C and n and m are independently 0-50; (ii) the two strands are joined at the ends by carbon spacers; (iii) the decoy binds to STAT3 protein under physiologic conditions and interferes with STAT3 binding to its target sequence; and (iv) the decoy has a serum half-life of greater than about 4 hours.