Patent ID: 8765970
Filing Date: 2014-07-01
Classification: C07D

Abstract:
1. An enantiomerically enriched 3-triazolyl sulphoxide of formula (I), wherein X R R where the enantiomer ratio is 60:40 to 99.5:0.5 (+):(−)enantiomer, and wherein said 3-triazolyl sulphoxide of formula (I) is prepared by a process comprising reacting a sulphide of formula (II) in which each of X with an oxidizing agent, in a solvent, and in the presence of a chiral catalyst, at a reaction temperature between 10° C. and 60° C., wherein the oxidizing agent is hydrogen peroxide; and the chiral catalyst is a chiral metal-ligand complex comprising a transition metal and a chiral ligand, wherein the transition metal is vanadium, iron or manganese.