Patent ID: 6268496
Filing Date: 2001-07-31
Classification: A61P,C07D

Abstract:
A compound of the formula I: ##STR32##and the pharmaceutically acceptable non-toxic saltswherein:R.sub.1 and R.sub.4 are the same or different and representhydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;X ishydrogen, halogen, hydroxy, or amino; ormono- or dialkylamino where each alkyl is lower alkyl having 1-6 carbon atoms;W isphenyl, thienyl, or pyridyl, orphenyl, thienyl, or pyridyl, each of which may be mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, amino, mono of dialkylamino where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;R.sub.2 and R.sub.3 are the same or different and representhydrogen, halogen, hydroxy, amino, 1-indanyl, 4-(thio)chromanyl, 1-(1,2,3,4-tetrahydronaphthyl);1-indanyl, 4-(thio)chromanyl, 1-(1,2,3,4-tetrahydronaphthyl), each of which is monosubstituted with halogen, straight or branched chain lower alkyl having 1-6, carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms:OR.sub.5, COR.sub.5, CO.sub.2 R.sub.5, OCOR.sub.5, or R.sub.5, where R.sub.5 is hydrogen, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms;--CONR.sub.6 R.sub.7 or --(CH.sub.2).sub.n NR.sub.6 R.sub.7 wheren is 0, 1, or 2;R.sub.6 is hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms;R.sub.7 is hydrogen, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; orNR.sub.6 R.sub.7 is a heterocyclic group which is morpholyl, piperidyl, pyrrolidyl, or N-alkyl-piperazinyl;--NR.sub.8 CO.sub.2 R.sub.9 where R.sub.8 and R.sub.9 are the same or different and represent hydrogen, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; orC(OH)R.sub.10 R.sub.11 where R.sub.11 and R.sub.11 are the same or different and represent straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl, or phenylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms.