Patent ID: 8461124
Filing Date: 2013-06-11
Classification: A61P,C07H

Abstract:
1. A ribonucleoside derivatives according to formula 1 or 2 as shown below: wherein N is a nucleobase moiety selected from the group consisting of: -1-thyminyl-, -9-adeninyl-, -9-guaninyl-, -1-cytosinyl-, -5-methyl-1-cytosinyl-, -5-fluoro-1-cytosinyl-, -5-fluoro-1-cytosinyl- and -5-trifluoromethyl-1-uracilyl-, respectively, T wherein in general formula 1 the ring is a 5-membered cis-fused carbocycle (fused at C4′ and C2′ of the β-D-pentofuranosyl ring of the ribo or arabino nucleoside or nucleotide) with substituents at C6′ (R/R′) and/or C7′ (Q Q and either R and/or R′ is a substituent at C6′ in R or S configuration; wherein R=H, OH, F, methyl, CF R in combination with R′ and the carbon to which they are attached is a (C═O) group, a (C═CH when, R=R′=H then one of the Q wherein in general formula 2 the ring is a 6-membered cis-fused carbocycle (fused at C4′ and C2′ of the β-D-pentofuranosyl ring of the ribo or arabino nucleoside or nucleotide) with substituents at C6′ (R/R′) and/or C7′ (P wherein Q and Q Q (ii) with the provisos that when Q and R=H, OH, F, methyl, CF and R′=H, OH, F, methyl, CF R in combination with R′ and the carbon to which they are attached is a (C═O) group, a (C═CH and P and P P with the proviso that when each of R, R′, P