Patent ID: 9044463
Filing Date: 2015-06-02
Classification: A61K,A61P,C07D

Abstract:
1. A compound according to Formula I or a pharmaceutically acceptable salt thereof, wherein Y—X is CH R2 is phenyl, (1-6C)alkyl, (2-8C)-heteroaryl, benzoyl, (2-8C)heteroarylcarbonyl, (1-8C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkoxy, all alkyl or alkoxy moieties of which may optionally be substituted with one or more substituents selected from R10 and the phenyl or heteroaryl moieties of which may optionally be substituted with one or more substituents selected from R12, or R2 is (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkylcarbonyl, (2-6C)alkenylcarbonyl, (2-6C)alkynylcarbonyl, (3-6C)cycloalkylcarbonyl, (3-6C)alkenoxy, (3-6C)cycloalkyl(1-4C)alkoxy, phenyl(1-4C)alkoxy or (2-8C)heteroaryl(1-4C)alkoxy; R6 is hydroxy or H, or R6 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-4C)alkoxy, (3-6C)alkenoxy, (3-6C)cycloalkyl(1-4C)alkoxy, (3-6C)cycloalkoxy, (3-6C)heterocycloalkyl(1-4C)alkoxy, halogen, cyano, the alkyl or alkoxy moieties of which may optionally be substituted with one or more substituents selected from R10, or R6 together with R7 is —O—(CH R6 and R7 may be joined in a (3-6C)cycloalkyl ring; R7 is hydroxy, H, or R7 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-4C)alkoxy, (3-6C)alkenoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkoxy, (3-6C)cycloalkoxy, (3-6C)heterocycloalkyl(1-4C)alkoxy, (3-6C)heterocycloalkoxy, (2-6C)heterocycloalkylcarbonyl, (di)[1-4C]alkylaminocarbonyl or (2-6C)heterocycloalkyl, the alkyl, alkoxy or (hetero)cycloalkyl moieties of which may optionally be substituted with one or more substituents selected from R11, or R7 is (2-8C)heteroaryl, phenyl, phenyl(1-4C)alkoxy, (2-8C)heteroaryl(1-4C)alkoxy, the phenyl or heteroaryl moieties of which may optionally be substituted with one or more substituents selected from R11, or R7 together with R6 is —O—(CH R7 and R6 may be joined in a (3-6C)cycloalkyl ring; R8 is H or (1-4C)alkoxy; R10 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, (1-4C)alkoxy, (1-4C)alkyl, aminocarbonyl or (di)[1-4C]alkylamino; R11 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, (1-4C)alkoxy, (di)[1-4C)alkyl]amino or (1-4C)alkyl; R12 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, (1-4C)alkoxy, (1-4C)alkyl, aminocarbonyl or (di)[1-4C]alkylamino; R13 is H or (1-3C)alkyl; R14 and R15 are independently H or (1-3C)alkyl, or R14 and R15 may be joined in a (3-6C)cycloalkyl ring.