Patent ID: 6162947
Filing Date: 2000-12-19
Classification: C07C

Abstract:
A process for the preparation of compound of formula (I) ##STR13## comprising the successive steps of: (a) reacting 2-chloro-3-(phenylmethoxy)propionic acid potassium salt of formula (II) ##STR14## in a solution and in the presence of an alkali or alkaline-earth metal (Me) oxide or hydroxide, with diethyltriamine to give the N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine salt of formula (III) with corresponding metal cation ##STR15## (b) purifying and concentrating the solution containing compound (III); (c) reacting compound (III) with bromoacetic acid while maintaining a basic pH; then(d) purifying and isolating compound (I).