Patent ID: 7304050
Filing Date: 2007-12-04
Classification: A61P,C07D

Abstract:
1. A compound which is: 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 9-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; or 7-{7-[5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl}-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; or a pharmaceutically acceptable salt thereof.