Patent ID: 6458796
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
Dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-ones of the general formula (I) in whichR1 represents cycloalkyl having 3 to 8 carbon atoms, or represents a radical of the formula â€ƒin which R2 represents straight-chain or branched alkyl having up to 10 carbon atoms which is optionally substituted by hydroxyl, E represents a radical of the formula â€”CH2â€”T, â€ƒin which T represents a straight-chain or branched alkylene chain having up to 10 carbon atoms, R3 represents hydrogen or aryl having 6 to 10 carbon atoms which is optionally substituted up to 3 times by identical or different substitutents from the group consisting of halogen, hydroxyl, nitro, trifluoromethyl and straight-chain or branched alkyl or alkoxy having in each case up to 6 carbon atoms, A and D represent hydrogen, or A represents hydrogen and D represents hydroxyl, or A and D together represent a radical of the formula &boxH;O, L represents a radical of the formula represents aryl having 6 to 10 carbon atoms or represents a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms from the group consisting of S, N and/or O, where the ring systems listed above under L are substituted up to 3 times by one or more identical or different of the following substituents: halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, straight-chain or branched alkyl, alkoxy and alkoxycarbonyl having in each case up to 6 carbon atoms, a radical of the formula â€”(V)aâ€”NR4R5, â€ƒin which a represents a number 0 or 1, V represents a radical of the formula â€”CO or â€”SO2, R4 and R5 are identical or different and represent hydrogen or straight-chain or branched acyl or alkoxycarbonyl having in each case up to 6 carbon atoms, or represent straight-chain or branched alkyl having up to 6 carbon atoms which is optionally substituted by hydroxyl, amino or by straight-chain or branched alkyl- or dialkylamino having in each case up to 6 carbon atoms, or R4 and R5 together with the nitrogen atom form a 5- or 6-membered saturated heterocycle which may optionally contain a further heteroatom from the group consisting of S and O or a radical of the formula â€”NR6 and which is optionally substituted by straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, â€ƒin which R6 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms, and/or the ring systems listed under L are optionally substituted by aryl having 6 to 10 carbon atoms and a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, where these ring systems for their part are optionally substituted up to 2 times by identical or different substituents from the group consisting of halogen, hydroxyl, nitro, carboxyl, trifluoromethyl and straight-chain or branched alkyl, alkoxy, or alkoxycarbonyl having in each case up to 5 carbon atoms, or by a group of the formula â€”(Vâ€²)bâ€”NR7R8, â€ƒin which b has the meaning of a given above and is identical to or different from this meaning, R7 and R8 have the meanings of R4 and R5 given above and are identical to or different from these meanings, Vâ€² has the meaning of V given above and is identical to or different from this meaning, and their tautomers and salts.