Patent ID: 6498251
Filing Date: 2002-12-24
Classification: A61P,C07D

Abstract:
A compound represented by formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, an alkoxy group, an acyl group, an acyloxy group, an alkoxycarbamoyl group, a nitro group, an amino group, a substituted amino group, a carbamoyl group or an alkylcarbamoyl group; n is an integer of from 2 to 6; and &agr; represents the following formula (a), (b), (c), or (d): whereinin formulae (a) and (b), R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group or an alkoxy group, X represents NR10, NCONR11R12, S, SO, SO2 or O, R10 represents a hydrogen atom, a lower alkyl group, an alkenyl group, an oxoalkyl group, an aralkyl group, a cyanoalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, an aminoalkyl group, a substituted aminoalkyl group, an alkoxycarbonylalkyl group, a carbamoylalkyl group, an alkylcarbamoylalkyl group, an acyl group or an alkoxycarbonyl, R11 and R12 independently represent a hydrogen atom or a lower alkyl group, and Y represents a methylene group or a carbonyl group, in formula (c), R4 represents a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, a cyano group, a trihalomethyl group, an alkoxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, an alkoxycarbonyl, a sulfamoyl group, an amino group, a substituted amino group, a carbamoyl group, an alkylcarbamoyl group, an acyl group or a carboxy group, R5 represents a hydrogen atom, a lower alkyl group, a hydroxy group, an alkoxy group, an acyl group, a phenyl group or a substituted phenyl group, k is 0 or an integer of from 1 to 3, m is 0 or an integer of from 1 to 3, and each of A and B represents a group which forms a benzene ring, a thiophene ring, a furan ring, an imidazole ring or a pyrazole ring via a double bond, with the proviso that k+m is an integer of from 1 to 3, and in formula (d), R4 is as defined in the foregoing, G represents CH2, S, O or C&boxH;O, D represents CH or N, p is an integer of from 1 to 3, and each of E and J represents a group which forms a benzene ring or a pyridine ring via a double bond or a pharmaceutically acceptable salt thereof.