Patent ID: 7566737
Filing Date: 2009-07-28
Classification: A61P,C07C

Abstract:
1. A pharmaceutical composition comprising, in a pharmaceutically acceptable support, at least one compound represented by formula (I) in association with another therapeutically active ingredient, wherein said compound is a substituted 1,3-diphenylprop-2-en-1-one derivative represented by formula (I) below: in which: X1 represents a halogen or a —R1 group or a group corresponding to the following formula: -G1-R1, X2 represents a hydrogen atom or a thionitroso group or a hydroxy group or an alkylcarbonyloxy or an unsubstituted alkyloxy group or a thiol group or an alkylthio group or an alkylcarbonylthio group, X2 can also represent an oxygen or sulfur atom bound to carbon 3 of the propene chain, so as to form a derivative of the type 2-phenyl-4H-1-benzopyran-4-one or of the type 2-phenyl-4H-1-benzothiopyran-4-one, X3 represents a —R3 group or a group corresponding to the following formula: -G3-R3, X4 represents a halogen or a thionitroso group or a —R4 group or a group corresponding to the following formula: -G4-R4, X5 represents a —R5 group or a group corresponding to the following formula: -G5-R5, X6 is an oxygen atom or a nitrogen atom, in the case where X6 is a nitrogen atom, it carries a hydrogen atom or a hydroxy group or an alkyloxy group, R1, R3, R4, R5, which are the same or different, represent a hydrogen atom or an alkyl group substituted or not by a substituent selected from group 1 or group 2 defined hereinbelow, G1, G3, G4, G5, which are the same or different, represent an oxygen or sulfur atom, with at least one of the groups X1, X3, X4 or X5 corresponding to the formula -G-R, and with at least one of the groups R1, R3, R4 or R5 present in the form of an alkyl group containing at least one substituent of group 1 or 2, said alkyl group being bound directly to the ring or being associated with a group G according to the formula -G-R, the substituents of group 1 are selected in the group consisting of carboxy groups corresponding to the formula: —COOR the substituents of group 2 are selected in the group consisting of sulfonic acid (—SO with R the optical and geometric isomers, racemates, tautomers, salts, and mixtures thereof.