Patent ID: 7303871
Filing Date: 2007-12-04
Classification: A23L,A23V,A61K,A61P,C07D,C07K,C12Y,G01N,Y02A

Abstract:
1. A method for treating a gluten-containing foodstuff to render said foodstuff less toxic to a Celiac Sprue patient, said method comprising contacting said foodstuff in vivo in said patient with a purified or recombinant prolyl endopeptidase orally administered to said patient, wherein said prolyl endopeptidase has a kcat/Km of at least 250 s −1 M −1 for cleaving PQPQLPYPQPQLPY (SEQ ID NO:3) under physiologic conditions, and wherein immunogenic gluten peptides in gluten-containing foodstuffs are cleaved into non-toxic fragments during said contacting step.