Patent ID: 6099830
Filing Date: 2000-08-08
Classification: A61K,Y10S

Abstract:
A method for stimulating erythropoiesis comprising:determining the hematocrit level in a mammal to be less than 33% of total blood volume, whereby said mammal is identified to be anemic;administering to said anemic mammal a composition comprising thrombopoietin (TPO) in combination with a pharmaceutically acceptable vehicle wherein the TPO comprises a sequence of amino acids selected from group consisting of:the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 1 to residue 172;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 1 to residue 173;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 1 to residue 175;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 1 to amino acid residue 353;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 22 to residue 353;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 22 to residue 172;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 22 to residue 173;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 22 to residue 175;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 28 to residue 172the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 28 to residue 173;the sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 28 to residue 175; andthe sequence of amino acids shown in SEQ ID NO:2 from amino acid residue 28 to residue 353;in an amount sufficient to produce an increase in hematocrit level above 33% of total blood volume; andmonitoring the hematocrit level following said administration.