Patent ID: 6169115
Filing Date: 2001-01-02
Classification: A61K

Abstract:
A method of treating or preventing a disease of the nervous system in a subject in need thereof comprising administering to said subject a therapeutically effective amount of an aminoguanidine, wherein said aminoguanidine has the formula: ##STR37## wherein a) R.sub.1 through R.sub.16, if present, are selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, and alkoxyl; b) J is either ##STR38## c) Q is either ##STR39## d) T, if present, is R.sub.12 or NR.sub.13 R.sub.14 ; e) Y is an alkylene, alkenylene, alkynylene or an alkoxylene; f) Z is selected from the group consisting of ##STR40## wherein B.sub.1 -B.sub.4 are each independently selected from hydrogen and OX.sub.4 and X.sub.1 -X.sub.4 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl and pharmaceutically acceptable salts; and wherein Y and Q or N and Q can form a ring structure.