Patent ID: 7563882
Filing Date: 2009-07-21
Classification: A61K,A61P,C07K

Abstract:
1. A composition which comprises an isolated first polynucleotide which encodes a humanized antibody heavy chain variable domain, and an isolated second polynucleotide which encodes a humanized antibody light chain variable domain, wherein said first polynucleotide comprises sequences that encode a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 of the 1B3 monoclonal antibody heavy chain that is encoded by SEQ ID NO: 151; wherein said second polynucleotide comprises sequences that encode a light chain CDR1, a light chain CDR2, and a light chain CDR3 of the 1B3 monoclonal antibody light chain that is encoded by SEQ ID NO: 150; and wherein an antibody or antigen binding fragment comprising said heavy chain variable domain and said light chain variable domain specifically binds to the C35 polypeptide of SEQ ID NO:2.