Patent ID: 8398974
Filing Date: 2013-03-19
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a cancer, comprising administering to a human patient in need thereof a monoclonal antibody, or antigen-binding fragment thereof, that binds human c-Met, comprising three light chain complementarity determining regions (LCDRs) and three heavy chain complementarity determining regions (HCDRs), wherein said three LCDRs and said three HCDRs are a LCDR1 comprising the amino acid sequence SVSSSVSSIYLH (SEQ ID NO: 53), a LCDR2 comprising the amino acid sequence STSNLAS (SEQ ID NO: 54), a LCDR3 comprising the amino acid sequence QVYSGYPLT (SEQ ID NO: 56), a HCDR1 comprising the amino acid sequence GYTFTDYYMH (SEQ ID NO: 65), a HCDR2 comprising the amino acid sequence RVNPNRRGTTYNQKFEG (SEQ ID NO: 68), and a HCDR3 comprising the amino acid sequence ANWLDY (SEQ ID NO: 69).