Patent ID: 7951912
Filing Date: 2011-05-31
Classification: A61K,A61P,C07D,C07K,C08G

Abstract:
1. A method of making β-polypeptides comprising polymerizing β-lactam-containing monomers in an organic solvent in the presence of a base initiator selected from the group consisting of KOtBu, LiN(TMS) 2 , KN(TMS) 2 , NaOEt, Sc(N(TMS) 2 ) 3 , Al 2 (N(Me) 2 ) 6 , Al(N(TMS) 2 ) 3 , Zn(N(TMS) 2 ) 2 , Sn(N(TMS) 2 ) 2 , and CpTi(N(Me) 2 ) 2 Cl, and a co-initiator which is not a metal-containing molecule, wherein the co-initiator is selected from the group consisting of: wherein X is a leaving group selected from the group consisting of alkoxide, amidate, carboxylate, halide, imidazolate, lactamate, and thiolate; and R is a base-stable moiety selected from the group consisting of linear, branched, or cyclic alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted arylalkyl;