Patent ID: 8846044
Filing Date: 2014-09-30
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition for increasing stability, reducing aggregation or reducing immunogenicity of a monoclonal antibody comprising: a monoclonal antibody; and a stabilizing agent comprising at least one alkylglycoside, wherein the alkylglycoside is selected from: octyl-, nonyl-, decyl-, undecyl-, dodecyl-, tridecyl-, tetradecyl, pentadecyl-, hexadecyl-, heptadecyl-, and octadecyl-D-maltoside and D-glucoside; octyl-, nonyl-, decyl-, undecyl-, dodecyl-, tridecyl-, tetradecyl, pentadecyl-, hexadecyl-, heptadecyl-, and octadecyl-maltoside; octyl-, nonyl-, decyl-, undecyl-, dodecyl-, tridecyl-, tetradecyl, pentadecyl-, hexadecyl-, heptadecyl-, and octadecyl-glucoside; octyl-, nonyl-, decyl-, undecyl-, dodecyl-, tridecyl-, tetradecyl, pentadecyl-, hexadecyl-, heptadecyl-, and octadecyl-sucroside; an alkyl thiomaltoside selected from heptyl, octyl, dodecyl-, tridecyl-, and tetradecyl-beta-D-thiomaltoside; an alkyl thioglucoside selected from heptyl- and octyl- 1-thio beta- and beta-D-glucopyranoside; an alkyl maltotrioside; a long chain aliphatic carbonic acid amide of sucrose amino-alkyl ether; a derivative of palatinose and isomaltamine linked by amide linkage to an alkyl chain; a derivative of isomaltamine linked by urea to an alkyl chain; a long chain aliphatic carbonic acid ureide of sucrose amino-alkyl ether; and a long chain aliphatic carbonic acid amide of sucrose amino-alkyl ether.