Patent ID: 6670340
Filing Date: 2003-12-30
Classification: A61K,A61P,C08B

Abstract:
A 6-mercapto-cyclodextrin derivative having the general formula I wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituted with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2â€”CH2â€”O)qâ€”H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof; with the exclusion of6-per-deoxy-6-per-(2-hydroxyethylthio)-&bgr;-cyclodextrin; 6-mono-deoxy-6-mono-(2-hydroxyethylthio)-&bgr;-cyclodextrin; 6-per-deoxy-6-per-(2-hydroxyethylthio)-&ggr;-cyclodextrin; 6-per-deoxy-6-per-(carboxymethylthio)-&bgr;-cyclodextrin; 6-mono-deoxy-6-mono-(carboxymethylthio)-&bgr;-cyclodextrin; 6A,6B-dideoxy-6A,6B-bis((o-carboxyphenyl)thio)-&bgr;-cyclodextrin; 6A,6B-dideoxy-6A,6B-bis(carboxymethylthiol)-&bgr;-cyclodextrin and 6-per-deoxy-6-per-(2,3-dihydroxypropylthio)-&bgr;-cyclodextrin.