Patent ID: 7148249
Filing Date: 2006-12-12
Classification: A61P,C07D

Abstract:
1. A compound of formula wherein X denotes an oxygen or sulphur atom, R R a cyano or nitro group, a carboxy group, a straight-chain or branched C an allyloxy-carbonyl group optionally substituted by one or two methyl groups, a straight-chain or branched C a straight-chain or branched C an aminocarbonyl, C R a 5- to 6-membered cyclic oxime ether which is linked to the methylidene group via the carbon atom adjacent to the nitrogen atom, an imidazo[1,2-a]pyridin-6-yl or imidazo[1,2-a]pyridin-7-yl group or a bicyclic group consisting of while the hydrogen atom of any carboxy group contained in R R or a phenyl group substituted by the group R R a cyano, nitro, amino, C a tetrazolyl group optionally substituted by a C a 2-pyrrolidon-1-yl group wherein the methylene group adjacent to the carbonyl group may be replaced by an oxygen atom or an —NH or —N(C the group of formula a group of formula wherein a group of formula wherein a C or R wherein a group of formula wherein an amino group substituted by a di-(C or a group of formula wherein or a group of formula wherein or R wherein R while by the term aryl group is meant a phenyl or naphthyl group optionally mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a cyano, trifluoromethyl, nitro, carboxy, aminocarbonyl, C by the term heteroaryl group is meant, unless otherwise stated, a monocyclic 5- or 6-membered heteroaryl group optionally substituted in the carbon skeleton by one or two C the hydrogen atoms in the abovementioned alkyl and alkoxy groups or in the alkyl moieties contained in the above-defined groups of formula I may be wholly or partly replaced by fluorine atoms, the saturated alkyl and alkoxy moieties containing more than 2 carbon atoms present in the groups defined above, also include the branched isomers thereof such as for example the isopropyl, tert.butyl, isobutyl group, unless otherwise stated, and wherein additionally the hydrogen atom of any carboxy group present or a hydrogen atom bound to a nitrogen atom, for example an amino, alkylamino or imino group or a saturated N-heterocycle such as the piperidinyl group, may each be replaced by a group which can be cleaved in vivo, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof.