Patent ID: 6168777
Filing Date: 2001-01-02
Classification: A61K,A61P

Abstract:
A method for causing necrosis to a portion of a solid mass prostate tumor in a male mammal which method comprises: (a) selecting a fluidic compositions comprising: (i) a biocompatible, non-cross-linked, non-biodegradable polymer which polymer is insoluble in body fluid of a mammal; (ii) a biocompatible solvent which is an organic material liquid at least at body temperature of the mammal and which solubilizes said polymer with the proviso that when said solvent comprises water, the amount of water employed is sufficiently small that the dissolved polymer precipitates upon contact with the blood; and (iii) a water insoluble radioisotope with the proviso that when the radioisotope is either water soluble or water reactable, said isotope is used as a water insoluble salt (b) injecting a sufficient amount of said composition into the prostate of a male mammal under conditions wherein a solid non-migratory precipitate is formed wherein the radioisotope is employed in an amount effective to cause necrosis of at least a portion of said tumor.