Patent ID: 7767806
Filing Date: 2010-08-03
Classification: A61K,C08B,C08G

Abstract:
1. A hyaluronic acid modification product, in which one or more polymers are introduced into glucuronic acid moieties in hyaluronic acid or a derivative thereof, the one or more polymers being selected from the group consisting of polylactic acid, polyglycolic acid, and lactic acid-glycolic acid copolymer; wherein said hyaluronic acid modification product has resistance to degradation by hyaluronidase compared with an unmodified hyaluronic acid; and wherein the polymer is bonded to the carboxyl group of the hyaluronic acid or derivative thereof by an amide bond via a spacer, resulting in a repeating structure of the formula (I): where R Ra and Rb are independently selected from the group consisting of a hydrogen atom and a C Q is a polymer selected from the group consisting of polylactic acid, polyglycolic acid, and lactic acid-glycolic acid copolymer, and the polymer forms an amide bond with nitrogen at a terminal carboxyl group thereof, A is a single bond, —(CH m is an integer of 1 to 10, and n is an integer of 0 to 10; wherein a repeating structure represented by the formula (I) is contained in a molecule of the hyaluronic acid modification product; wherein the molecule of the hyaluronic acid modification product optionally contains a repeating structure of the formula (II): where R Ra and Rb are independently a hydrogen atom or a C A is a single bond, —(CH m is an integer of 1 to 10, and n is an integer of 0 to 10; and wherein carboxylic groups in glucuronic acid moieties of hyaluronic acid or a derivative thereof are modified to give the repeating structures represented by the formula (I) or (II) at a modification rate of 50% or more, of at least one repeating structure of formula (I) and optionally at least one repeating structure of formula (II); or a pharmaceutically acceptable salt thereof.