Patent ID: 7893191
Filing Date: 2011-02-22
Classification: C07D

Abstract:
1. A method for making a β″-R-substituted fused thiophene moiety comprising the steps of: (i) providing an α-hydro β-halogen-substituted thiophene moiety, wherein the halogen is selected from chlorine, bromine and iodine; (ii) acylating the thiophene moiety at the α-position with an R-acyl moiety, where R is a group having at least four carbons, (iii) substituting the β-halogen-substituent with a 2-mercaptoacetate; (iv) cyclizing the α-(R-acyl)-β-carboxymethylthio thiophene moiety to form an α″-carboxy-β″-R-substituted fused thiophene moiety; and (v) decarboxylating the α″-carboxy β″-R-substituted fused thiophene moiety to form the β″-R-substituted fused thiophene moiety.