Patent ID: 7247767
Filing Date: 2007-07-24
Classification: A01K,C12N

Abstract:
1. A transgenic mouse whose genome comprises deletions of c-Jun and JunB genes in keratinocytes of the epidermis, wherein said transgenic mouse is a double knockout for said c-Jun and JunB genes in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme, and wherein said transgenic mouse exhibits one or more characteristics selected from the group consisting of an abnormally thickened epidermis, parakeratosis, hyperkeratosis, fingerlike epidermal projections into the dermis, granulocytic infiltrates into the joint region, rete ridges, epidermal microabscesses, intraepidermal T-cells, increased numbers of neutrophils, macrophages in the dermis, or combinations thereof.