Patent ID: 8618266
Filing Date: 2013-12-31
Classification: A61K,A61P,C07K,C08B,C08H

Abstract:
1. A hydroxyalkylstarch (HAS)-erythropoietin (EPO)-conjugate (HAS-EPO), comprising one or more HAS molecules, wherein the EPO comprises one or more carbohydrate side chains attached to the EPO via N-linked, O-linked, or N-linked and O-linked glycosylation, wherein each HAS is conjugated to the EPO via a carbohydrate moiety that is part of the carbohydrate side chains, wherein the HAS is conjugated to the EPO via O-[2-(2-aminooxy-ethoxy)-ethyl]-hydroxylamine, and wherein the reaction between the HAS and the O-[2-(2-aminooxy-ethoxy)-ethyl]-hydroxylamine takes place at the non-oxidized reducing end of the HAS.