Patent ID: 6232308
Filing Date: 2001-05-15
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR11##or a pharmaceutically acceptable salt thereof, whereinY is selected from the group consisting of--(CH.sub.2).sub.m --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO.sub.2 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --, and--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --;wherein any methylene (CH.sub.2) carbon atom in Y, other than in R.sup.4, can be substituted by one or two R.sup.3 substituents;Z is selected from the group consisting of ##STR12##wherein the ring carbon atoms are unsubstituted or substituted with one or two R.sup.6 substituents;R.sup.1 and R.sup.2 are each independently selected from the group consisting ofhydrogen,halo,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,C.sub.3-8 cycloalkyl,C.sub.3-8 cycloheteroalkyl,C.sub.3-8 cycloalkyl C.sub.1-6 alkyl,C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl,aryl,aryl C.sub.1-6 alkyl,amino C.sub.1-6 alkyl,C.sub.1-4 acylamino C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,hydroxy C.sub.1-6 alkyl,C.sub.1-6 alkoxy C.sub.1-6 alkyl,C.sub.1-6 alkylthio C.sub.1-6 alkyl,hydroxycarbonyl C.sub.1-6 alkyl,C.sub.1-4 alkoxycarbonyl C.sub.1-6 alkyl, andtrifluoromethyl;each R.sup.3 is independently selected from the group consisting ofhydrogen,halo,aryl,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,aryl C.sub.1-6 alkyl,C.sub.3-8 cycloalkyl,hydroxyl,oxo,trifluoromethyl,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,C.sub.1-6 alkylthio,aryl C.sub.1-6 alkylthio,aminocarbonyl,(C.sub.1-6 alkyl).sub.p aminocarbonyl,arylaminocarbonyl,aryl C.sub.1-6 alkylaminocarbonyl,aryloxycarbonylamino,C.sub.1-6 alkoxycarbonylamino,aryl C.sub.1-6 alkoxycarbonylamino,arylcarbonylaminoC.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-6 alkylsulfonylamino,arylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino,C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylcarbonyl, andaryl C.sub.1-6 alkylcarbonyl,or two R.sup.3 substituents, when on the same carbon atom are taken together with the carbon atom to which they are attached to form a carbonyl group or a cyclopropyl group,wherein any of the alkyl groups of R.sup.3 are either unsubstituted or substituted with one to three R.sup.1 substituents, and provided that each R.sup.3 is selected such that in the resultant compound the carbon atom or atoms to which R.sup.3 is attached is itself attached to no more than one heteroatom;each R.sup.4 is independently selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,aryl C.sub.1-6 alkyl,C.sub.1-4 alkoxy C.sub.1-6 alkyl,C.sub.3-8 cycloalkyl,C.sub.1-6 alkylsulfonyl,arylsulfonyl,arylC.sub.1-6 alkylsulfonyl,C.sub.1-6 alkoxycarbonyl,aryloxycarbonyl,aryl C.sub.1-6 alkoxycarbonyl,C.sub.1-6 alkylcarbonyl,arylcarbonyl,aryl C.sub.1-6 alkylcarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,C.sub.1-4 alkoxycarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl,(aryl) C.sub.1-6 alkyl).sub.p aminocarbonyl, and(C.sub.1-6 alkyl).sub.p aminocarbonyl;wherein any of the alkyl groups of R.sup.4 are either unsubstituted or substituted with one to three R.sup.1 substituents;R.sup.5 is selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,aryl,aryl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyloxy C.sub.1-4 alkyl,aryl C.sub.1-6 alkylcarbonyloxy C.sub.1-4 alkyl,C.sub.1-6 alkylaminocarbonylmethylene, andC.sub.1-6 dialkylaminocarbonylmethylene;each R.sup.6 is selected from the group consisting ofhydrogen,cyano,nitro,halo,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,C.sub.3-8 cycloalkyl,C.sub.3-8 cycloheteroalkyl,C.sub.3-8 cycloalkyl C.sub.1-6 alkyl,C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl,aryl,aryl C.sub.1-6 alkyl,amino,C.sub.1-4 acylamino,(C.sub.1-6 alkyl).sub.p amino,C.sub.1-6 alkoxy,C.sub.1-6 alkylthio,hydroxycarbonyl,aminocarbonyl,(C.sub.1-6 alkyl).sub.p aminocarbonyl,C.sub.1-4 alkoxycarbonyl,hydroxy,trifluoromethyl, andtrifluoromethoxy;R.sup.7 is selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,C.sub.3-8 cycloalkyl,C.sub.3-8 cycloheteroalkyl,C.sub.3-8 cycloalkyl C.sub.1-6 alkyl,C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl, andaryl C.sub.1-6 alkyl;R.sup.8 is selected from the group consisting ofhydrogen,aryl,C.sub.1-8 alkyl,C.sub.2-8 alkenyl,C.sub.2-8 alkynyl,C.sub.3-8 cycloalkyl,C.sub.3-8 cycloheteroalkyl,C.sub.3-8 cycloalkyl C.sub.1-6 alkyl,C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkylaryl C.sub.1-6 alkyl,trifluoromethyl,2,2,2-trifluoroethyl,hydroxycarbonyl C.sub.1-6 alkyl,C.sub.1-4 alkoxycarbonyl C.sub.1-6 alkyl, andC.sub.1-4 alkoxy C.sub.1-6 alkyl;each m is independently an integer from 0 to 6;each n is independently an integer from 0 to 6; andeach p is independently an integer from 0 to 2.