Patent ID: 6468992
Filing Date: 2002-10-22
Classification: A61P,C07F

Abstract:
A method of treating diabetes which comprises administering to a diabetic patient a diabetes treatment effective amount of a phosphonic acid diester derivative represented by the general formula: wherein:R1 represents an amino group, a N-lower alkylamino group, a N-lower alkenylamino group, a N-phenylamino group, a N-phenylamino group whose benzene ring are substituted with 1 or 2 groups being selected from a halogen atom and a lower alkoxy group, a N-phenyl(lower)alkylamino group, a N,N-di(lower)alkylamino group or a 4-lower alkylpiperazinyl group; R2 and R3 each independently represent a hydrogen atom, a lower alkyl group, a halogen atom, a lower alkoxy group, a nitro group, an amino group, a N-lower alkylsulfonylamino group or a N-lower alkanoylamino group; R4 represents a hydrogen atom, a lower alkyl group or a phenyl(lower)alkyl group; R5 and R6 each independently represent a lower alkyl group; X, Y and Z each are carbon atoms or one of them is nitrogen atom and the other two are carbon atoms; and Q represents a single bond or an alkylene group; or a pharmacologically acceptable salt thereof.