Patent ID: 6555131
Filing Date: 2003-04-29
Classification: A61F,A61K,A61P

Abstract:
A transdermal therapeutic system for transcutaneous administration of levonorgestrel and additional optional sex steroids over a period of up to seven days, wherein the system comprises a layer of a steroid-containing matrix composition disposed on a carrier film, said matrix composition comprising a solid solution of (a) a copolymer of ethyl acrylate and methyl methacrylate containing about 5% trimethylammonium ethyl methacrylate chloride as the sole (meth)acrylate copolymer, (b) about 20 weight percent to about 30 weight percent of one or more plasticizers selected from the group consisting of esters of weak organic acids, (c) an optional fatty acid ester, and (d) at least 2 weight percent of levonorgestrel and each optional sex steroid distributed in the matrix composition as a molecular dispersion, wherein the system contains at least one sex steroid hormone which had minimum thermal exposure, and wherein the system is free of an adhesive layer.