Patent ID: 6639023
Filing Date: 2003-10-28
Classification: C08F,G01N

Abstract:
A fluorophenyl resin compound of formula wherein is a solid support; A is selected from L is a chemical bond, m is 1 to 5; p is 0, 1 or 2; B is F, OW or SO2Z; D is CH or N; W is hydrogen, tripyrrolidinophosphonium, C(O)V, C(O)Ra, C(O)NRbRc, C(O)Ora, SO2Ra or V is Cl or imidazol-1-yl; Y is O or NR3; Z is Cl, â€”OH, ORa or NRaRi; Ra and Rf are independently aliphatic or aromatic; Rb and Rc are independently H, aliphatic or aromatic, or Rb and Rc, taken together with the N atom through which they are attached, form an azaheterocyclyl or azaheterocyclenyl; Ri is CH2Rf; R0, R1 and R2 are a ring system substituent, or R0 and R1 taken together with the adjacent carbon atoms through which they are linked form a 6 membered aryl or 5 to 6 membered heteroaryl; R3 is H or lower alkyl; R4, R5, R6 and R7 are independently ring system substituents, or R4 and R5 taken together with the carbon atoms through which they are linked form a 6 membered aryl or 5 to 6 membered heteroaryl; and R11 and R12 are independently alkyl, heteroaryl, or aryl.