Patent ID: 6559320
Filing Date: 2003-05-06
Classification: C07D

Abstract:
A process for preparing a pyrrole ester derivative represented by the following formula (1): in whichR represents alkyl, allyl, or aryl, and R1 represents C1-C4-alkyl, characterized by reacting an aldehyde compound represented by the following formula (2): in which R is defined as previously described, with a trialkylphosphonoacetate represented by the following formula (3): in which R1 is defined as previously described, in an inert solvent in the presence of an alkali metal alkoxide base in an amount of 1 to 1.5 molar equivalent with respect to the compound of formula (2) to give an &agr;,&bgr;-unsaturated ester compound represented by the following formula (4): in which R and R1 are defined as previously described, and subsequently by adding TosMJC and the same base as used in the previous step in an amount of 1 to 1.5 molar equivalent with respect to the compound of formula (2).