Patent ID: 6060459
Filing Date: 2000-05-09
Classification: A61K,C07D,C07H,Y10S

Abstract:
A method for treating or preventing cytopenia comprising administering to an animal a pharmaceutically effective amount of one or more compounds having the formula: ##STR29## where: R.sub.A =H or an acyl radical of a carboxylic, alkylphosphonic, or alkylsulfonic acid, an acyl radical of an alkylphosphate or alkyl sulfate, or an alkyl radical, with 2 to 30 carbon atoms, andR.sub.B =H or an acyl radical of a carboxylic, alkylphosphonic, or alkylsulfonic acid, an acyl radical of an alkyl phosphate or alkyl sulfate, or an alkyl radical, with 2 to 30 carbon atoms, andZ=H; OH; .dbd.O divalently bound to the carbon in which case the adjacent carbon-nitrogen double bond is a single bond and an H is then attached to that nitrogen; or NHR.sub.C where R.sub.C =H or an acyl radical of a carboxylic acid with 2 to 30 carbon atoms, or an alkyl radical with 2-30 carbon atoms, andL=H or OR.sub.D, where R.sub.D =H or an acyl radical of a carboxylic, alkylphosphonic, or alkylsulfonic acid, an acyl radical of an alkyl phosphate or alkyl sulfate, or an alkyl radical, with 2 to 30 carbon atoms, andM=H or OR.sub.E, where R.sub.E =H or an acyl radical of a carboxylic, alkylphosphonic, or alkylsulfonic acid, a radical of an alkyl phosphate or alkyl sulfate, or an alkyl radical, with 2 to 30 carbon atoms, with the proviso that at least one of L and M is H, andQ=H; a halogen; NHR.sub.F where R.sub.F is H or an acyl or alkyl radical containing 1 to 10 carbon atoms; S divalently bound to the carbon in which case the adjacent carbon-nitrogen double bond is a single bond and an H is then attached to that nitrogen; SR.sub.G where R.sub.G is H or an acyl or alkyl radical containing 1 to 10 carbon atoms; O divalently bound to the carbon, in which case the adjacent carbon-nitrogen double bond is a single bond and an H is then attached to that nitrogen; or OR.sub.H where R.sub.H is H or an acyl or alkyl radical containing 1 to 10 carbon atoms, andthe C--C bond between the 2' and 3' positions of the aldose moiety is optionally present, ##STR30## where Z=NHR.sub.C where R.sub.C =H or an acyl radical of a carboxylic acid with 2 to 30 carbon atoms, or an alkyl radical with 2-30 carbon atoms, andQ=H; a halogen; NHR.sub.F where R.sub.F is H or an acyl or alkyl radical containing 1 to 10 carbon atoms; S divalently bound to the carbon in which case the adjacent carbon-nitrogen double bond is a single bond and an H is then attached to that nitrogen; SR.sub.G where R.sub.G is H or an acyl or alkyl radical containing 1 to 10 carbon atoms; O divalently bound to the carbon, in which case the adjacent carbon-nitrogen double bond is a single bond and an H is then attached to that nitrogen, or OR.sub.H where R.sub.H is H or an acyl or alkyl radical containing 1 to 10 carbon atoms,or a pharmaceutically acceptable salt thereof.