Patent ID: 8658634
Filing Date: 2014-02-25
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating an immunosuppressant disorder associated with the sphingosine-1-phosphate receptor modulation, wherein the immunosuppressant disorder is selected from: rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune uveitis, dry eye, inflammatory bowel diseases, atopic allergy, atopic dermatitis, contact dermatitis, multiple sclerosis, Sjogren's syndrome and organ transplant rejection, in a mammal in need thereof, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound represented by Formula I or a pharmaceutically acceptable salt thereof: wherein: represents a single bond, or a double bond represents a single bond, or a double bond or a triple bond A is substituted or unsubstituted C R R R R R R R R R L L a is 0 or 1; b is 0, 1, 2 or 3; c is 0, 1, 2 or 3; d is 0, 1, 2 or 3; with the provisos when a is 1 then  represents  and when a is 0 then R