Patent ID: 8927739
Filing Date: 2015-01-06
Classification: C07D

Abstract:
1. A process for the preparation of a compound of Formula (I): wherein R is selected from the group consisting of hydrogen, C said process comprising: (a) reacting a compound of Formula (II): with an oxidizing reagent to yield a compound of Formula (III): (b) reacting the compound of Formula (III) with an olefination reagent to provide a compound of Formula (IV): (c) reacting the compound of Formula (IV) with a monohalocarbene or dihalocarbene, wherein each halo is independently bromo or chloro, to yield a compound of Formula (V): wherein X at each occurrence is independently selected from the group consisting of hydrogen, bromine and chlorine wherein at least one of the two X groups is chlorine or bromine; (d) maintaining the compound of Formula (V) under conditions for reductive hydrodehalogenation to provide a compound of Formula (I): wherein R and PG are as previously defined; and (e) optionally,