Patent ID: 6248765
Filing Date: 2001-06-19
Classification: A61P,C07D,G01N

Abstract:
A compound selected from the group consisting of ##STR156##wherein A is selected from the group consisting of alkylene of 1 to 8 carbon atoms, alkenylene of 2 to 8 carbon atoms, alkynylene of 2 to 4 carbon atoms, wherein X is --OCONH--, --OCON(alkyl)-, --OCO--, --O--, --S--, --CO--, and amine;B is selected from the group consisting of optionally unsaturated alkylene of 1 to 8 carbon atoms and --(CH.sub.2).sub.n (heteroatom) where the heteroatom is sulfur or oxygen, n is an integer of 1 to 5;Y is selected from the group consisting of a) phenyl substituted with at least one member of the group consisting of --OCF.sub.3, --CHO, --SO.sub.2 N(alkyl).sub.2, --S(alkyl), --SCH.sub.2 (phenyl), alkene, alkyne optionally substituted with a trialkylsilyl, --O(aryl), --CH.sub.2 CN, a ketone, an aldehyde, a sulphono, an acetal, --OH, --CH.dbd.CH--CHO, --C(alkyl).dbd.N--OH, --C(alkyl).dbd.N--OH, --C(alkyl).dbd.N--O(alkyl), --CH--NOH, --CH.dbd.NO(alkyl), --C(alkyl)--NH--NH--CONH.sub.2, --O-alkyl, --OCH.sub.2 (phenyl), --C(cycloalkyl).dbd.NOH or --C(cycloalkyl).dbd.N--O(alkyl)- heterocycle optionally substituted; b) phenyl ring fused in a non-aromatic carbocycle or an heterocycle bearing a keto function; c) alkynyl or alkenyl of 2 to 8 carbon atoms substituted with phenyl, optionally substituted diphenyl alkyl ketone or a phenylcycloalkyl ketone; d) optionally substituted benzophenone; e) optionally substituted alkyl or cycloalkyl phenyl alcohol; f) alkene; g) phenylcycloalkyl; h) polycyclic selected from the group consisting of fluorenyl, polyhydronaphthyl and indanyl; i) phenol; j) ketone; k) diphenyl; l) phenoxyphenyl and m) benzyloxyphenyl, with the exception of the 4-[2-(4-acetylphenoxy)ethyl]-1H-imidazol]- and 4-[2-(4-benzoylphenoxy)ethyl]-1H-imidazole or their pharmaceutically acceptable salts, their hydrates, their hydrated salts, the polymorphic crystalline structures and the tautomeric forms of those compounds; and their optical isomers, racemic mixtures of said isomers and the corresponding diastereoisomers with the exception of the 4-[2-(4-acetylphenoxy)ethyl]-1H-imidazol]- and 4-[2-(4-benzoylphenoxy)ethyl]-1H-imidazol.