Patent ID: 6472422
Filing Date: 2002-10-29
Classification: A61P,C07B,C07D

Abstract:
A compound of formula I: whereinY is -O-; R1is -C(&boxH;O)ORa, cyano, (C1-C6)alkanoyl, (C2-C6) alkynyl, or 1, 2, 4-oxadiazol-5-yl optionally substituted at the 3-position by W, wherein any (C1-C6)alkanoyl, or (C2-C6)alkynyl may optionally be substituted by 1, 2, or 3 Z. wherein each Z is independently halo, nitro, cyano, hydroxy, (C1-C6)alkoxy, (C2-C6) acyloxy, C(&boxH;O)ORb, C(&boxH;O)NRcRd, NRcRfor S(&boxH;O)nRg; and R3 is (C6-C10)aryl, 5-10 membered heteroaryl, (C6-C10)aryl(C1-C10)alkyl, 5-10 membered heteroaryl (C1-C6)alkyl, (C6-C10)arylcarbonyl, or 5-10 membered heteroarylcarbonyl, wherein any aryl or heteroaryl substituent may optionally be substituted on carbon by 1, 2 or 3 Z; or R1 is -CH2-, or -CH2CH2-, wherein R1is attached to a carbon at he ortho position of R3; and R3is (C6-C10)aryl, or 5-10 membered heteroaryl; R2 is hydrogen or (C1-C6)alkyl; R4 and R5 are independently hydrogen or (C1-C6)alkyl; R6 is hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, or S(O)2Rh; n is 0, 1 or 2; W is (C1-C6)alkyl, or phenyl, optionally substituted by 1, 2, or 3 Z; Ra to Rg are independently hydrogen or (C1-C4) alkyl;and, Rh is H, (C1-C4alkyl, or phenyl; or a pharmaceutically acceptable salt thereof.