Patent ID: 6380191
Filing Date: 2002-04-30
Classification: A61P,C07D

Abstract:
A compound having the formula I: whereinAr1 is (1) arylene or (2) heteroarylene, â€ƒwherein said arylene or heteroarylene is optionally substituted with from 1 to 4 groups independently selected from Ra, R, or a mixture thereof, Ar2 is (1) aryl or (2) heteroaryl, â€ƒwherein said aryl or heteroaryl is substituted with 1-2 groups independently selected from R, provided that if only one cycloalkyl is present on Ar2, the cycloalkyl is not in the ortho position, and said aryl or heteroaryl is optionally further substituted with from 1-3 groups independently selected from Ra; X and Y are independently O, S, Nâ€”Rb, or CH2; Z is O; n is 0 to3; R is (1) C3-8 cycloalkyl, optionally substituted with 1-15 halogen atoms, 1-3 groups independently selected from C1-6 alkyl, and mixtures thereof; or (2) a 3-10 membered heterocycle containing one or more heteroatoms selected from N, S, O, and SO2, said heterocycle being optionally substituted with 1-3 halogen atoms or one to three C1-6 alkyl groups; Ra is (1) C1-15 alkanoyl, (2) C1-15 alkyl, (3) C2-15 alkenyl, (4) C2-15 alkynyl, (5) halo, (6) ORb, (7) aryl, or (8) heteroaryl, â€ƒwherein said alkyl, alkenyl, alkynyl, and alkanoyl are optionally substituted with from 1-5 groups selected from Rc, and said aryl and heteroaryl are optionally substituted with 1 to 5 groups selected from Rd; Rb is (1) hydrogen, (2) C1-10alkyl, (3) C2-10alkenyl, (4) C2-10alkynyl, (5) aryl, (6) heteroaryl, (7) aryl C1-15 alkyl, (8) heteroaryl C1-15 alkyl, (9) C1-15 alkanoyl, (10) C3-8 cycloalkyl, â€ƒwherein said alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from Rc, and said cycloalkyl, aryl and heteroaryl are optionally substituted with one to four substituents independently selected from Rd; Rc is (1) halo, (2) aryl, (3) heteroaryl, (4) CN, (5) NO2, (6) ORf; (7) S(O)mRf, m=0, 1 or 2, provided that Rf is not H when m is 1 or 2; (8) NRfRf, (9) NRfCORf, (10) NRfCO2Rf, (11) NRfCON(Rf)2, (12) NRfSO2Rf, provided that Rf is not H, (13) CORf, (14) CO2Rf, (15) CON(Rf)2, (16) SO2N(Rf)2, (17) OCON(Rf)2, or (18) C3-8cycloalkyl, â€ƒwherein said cycloalkyl, aryl and heteroaryl are optionally substituted with 1 to 3 groups independently selected from halo and C1-6 alkyl; Rd is (1) a group selected from Rc, (2) C1-10 alkyl, (3) C2-10 alkenyl, (4) C2-10 alkynyl, (5) aryl C1-10 alkyl, or (6) heteroaryl C1-10 alkyl, â€ƒwherein said alkyl, alkenyl, alkynyl, aryl C1-10 alkyl, and heteroaryl C1-10 alkyl are optionally substituted with a group independently selected from Re; Re is (1) halogen, (2) amino, (3) carboxy, (4) C1-4alkyl, (5) C1-4alkoxy, (6) hydroxy, (7) aryl, (8) aryl C1-4 alkyl, or (9) aryloxy; Rf is (1) hydrogen, (2) C1-10 alkyl, (3) C2-10 alkenyl, (4) C2-10 alkynyl, (5) aryl, (6) heteroaryl, (7) aryl C1-15 alkyl, (8) heteroaryl C1-15 alkyl, (9) C1-15 alkanoyl, (10) C3-8 cycloalkyl; â€ƒwherein said alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkanoyl and cycloalkyl are optionally substituted with one to four groups independently selected from Re; or a pharmaceutically acceptable salt thereof.