Patent ID: 6562842
Filing Date: 2003-05-13
Classification: C07C,C07D,C12N,C12Q,G01N

Abstract:
A compound according to Formula VIII: wherein:m is 0, 1, or 2; R32 is OCH2Ar, OCH2C1-6alkyl, aryl substituted C0-6alkyl, heteroaryl substituted C0-6alkyl, 4-imidazole methylene; 2-, 3-, or 4- pyridylmethyleneoxy; 4-pyridyl methylene, 2-pyridyl sulfonyl, 4-pyridyl, aryl C0-6alkyloxy, or heteroaryl substituted C0-6alkyloxy; R33 is C1-6alkyl, â€”CH2Ph, or â€”CH2CH2CO2R34; R34 is â€”H or C1-6alkyl; R38 is Cbz; C1-6alkyl or aryl substituted Cbz; C1-6alkyl â€”CO; benzoyl; C1-6alkyl or aryl substituted benzoyl; R39 is Cbz-leucinyl-; 2-, 3-, or 4-pyridyl methyloxycarbonyl-leucinyl-; 4-imidazole acetyl-leucinyl-, phenyl acetyl-leucinyl, N,N-dimethyl-glycinyl leucinyl, 4-pyridyl acetyl-leucinyl, 2-pyridyl sulfonyl-leucinyl, 4-pyridyl carbonyl-leucinyl, acetyl-leucinyl, benzoyl-leucinyl, 4-phenoxy-benzoyl-, 2- or 3-benzyloxybenzoyl-, biphenyl acetyl, alpha- isobutyl-biphenyl acetyl, Cbz-phenylalaninyl, Cbz-norleucinyl-, Cbz-norvalinyl-, Cbz-glutamyl-, Cbz-epsilon-(t-butyl ester)-glutamyl; acetyl-leucinyl-, 6- or 8- quinoline carbonyl, biphenyl acetyl, alpha- isobutyl-biphenyl acetyl, acetyl, benzoyl, 2- or 3-benzyloxy benzoyl, 4-phenoxy benzoyl-, Cbz-amino acid-; 2-,3-, or 4-pyridylmethyloxycarbonyl-aminoacid-; aryl C0-C6alkyloxy carbonyl-amino acid-, heteroaryl C0-C6alkyloxy carbonyl-amino acid-, aryl C0-C6alkyloxy carbonyl-amino acid-, heteroaryl C0-C6alkyloxy carbonyl-amino acid-, C1-C6alkyloxy carbonyl-amino acid-; C1-C6alkyl carbonyl, aryl C0-C6alkyl carbonyl, heteroaryl C0-C6alkyl carbonyl, aryl C0-C6alkyl carbonyl, heteroaryl C0-C6alkyl carbonyl, C1-C6alkyl sulfonyl, aryl C0-C6alkyl sulfonyl, heteroaryl C0-C6alkyl sulfonyl, aryl C0-C6alkyl sulfonyl, or heteroaryl C0-C6alkyl sulfonyl; R40 is H or C1-6alkyl; R41 is H or C1-6alkyl; R42 is C1-6alkyl, aryl substituted C1-6alkyl, or heteroaryl substituted C1-6alkyl; provided that R42 is H when R43 is C1-6alkyl, aryl substituted C1-6alkyl, or heteroaryl substituted C1-6alkyl; R43 is C1-6alkyl; aryl substituted C1-6alkyl, or hetero aryl substituted C1-6alkyl; provided that R43 is H when R42 is C1-6alkyl, aryl substituted C1-6alkyl; or heteroaryl substituted C1-6alkyl; and pharmaceutically acceptable salts, hydrates, or solvates thereof.