Patent ID: 6906091
Filing Date: 2005-06-14
Classification: A61K,A61P

Abstract:
1. A method for reducing incidence of cancer in a subject in need therefore and at risk for developing cancer comprising administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of a pharmaceutically acceptable prodrug of a benzimidazole having the formula: wherein X is hydrogen, halogen, or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chloro, nitro, oxychloro, methyl or ethyl; R is hydrogen or an alkyl group having from 1 to 8 carbon atoms; and R wherein the pharmaceutically acceptable prodrug of a benzimidazole is an acetate, formate, or benzoate derivative of alcohol or amine functional group of the benzimidazole, or a phosphate ester dimethylglycine ester, aminoalkylbenzyl ester, aminoalkyl ester or a carboxyalkyl ester of alcohol or phenol functional group of the benzimidazole; and wherein the incidence of cancer is reduced in the subject thereby.