Patent ID: 6670349
Filing Date: 2003-12-30
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical composition, comprising a carrier, a folinic acid, or a pharmaceutically or veterinarily acceptable salts thereof, and an amount of an active agent effective for altering levels of, or sensitivity to, adenosine in a subject's tissue(s), or prophtlaxis or treatment for bronchoconstriction, or asthma selected from dehydroepiandrosterone or pharmaceutically or veterinarily acceptable salts thereof, the dehydroepiandrosterone having the chemical formula wherein the broken line represents a single or a double bond; R is hydrogen or halogen; the H at position 5 is present in the alpha or beta configuration or the compound of chemical formula I comprises a racemic mixture of both configurations; and R1 is hydrogen or SO2OM, wherein M is H, Na, sulfatide â€”SO2Oâ€”CH2CHCH2OR3; or phosphatide wherein R2 and R1, which may be the same or different, is straight or branched (C1-C14) alkyl, or glucuronide 3,4-Dihydroxy-3,5,6-trimethyl-tetrahydro-pyran-2-carboxylic acid; or a ubiquinone or pharmaceutically or veterinarilly acceptable salt thereof, wherein the ubiquinone has the chemical formula â€ƒwherein n=1 to 12.