Patent ID: 6159937
Filing Date: 2000-12-12
Classification: A61K,A61P,C07K

Abstract:
A substance which is(I) a polypeptide amounting to 9 to 20 amino acids, said polypeptide comprising the following sequence:X.sub.1 -X.sub.2 -X.sub.3 -Thr-X.sub.4 -Lys-X.sub.5 -Arg-X.sub.6(SEQ ID NO: 22),whereinX.sub.1 is Ala or Gly,X.sub.2 is Tyr or Phe,X.sub.3, X.sub.4 and X.sub.5 are independently selected from the group consisting of Met, Ile, Leu and Val; andX.sub.6 is selected from the group consisting of Asn, Asp, Gln and Glu,and which has one or more of the following properties:(a) induces inhibition of spontaneous IL-8 production by human monocytes,(b) induces inhibition of IL-1.beta. induced IL-8 production by human peripheral blood mononuclear cells,(c) induces production of interleukin-1 receptor antagonistic protein (IRAP) by human monocytes,(d) induces chemotactic migration of CD8.sup.+ human T lymphocytes in vitro,(e) desensitizes human CD8.sup.+ T cells resulting in an unresponsiveness towards recombinant human IL-10 (rhIL-10),(f) suppresses the chemotactic response of CD4.sup.+ human T lymphocytes towards IL-8,(g) suppresses the chemotactic response of human monocytes towards MCAF/MCP-1,(h) induces the production of IL-4 by cultured normal human CD4.sup.+ T cells, or(i) reduces the TNFA production in human mixed leukocyte reaction, or,(II) a salt, ester or a conjugate of said polypeptide, but said conjugate is not IL-10 or a fragment of IL-10 which amounts to more than 20 amino acids of IL-10.