Patent ID: 6362174
Filing Date: 2002-03-26
Classification: C07C,C07D

Abstract:
A method of treating stroke, the method comprising administering to a mammal having a stroke a therapeutically effective amount of a compound having structural Formula I: whereinR1 is H or methyl, R2 is H, azepanylcarbonyl, C1-C7 alkyl, â€”(CH2)n-phenyl, wherein the phenyl is unsubstituted or substituted with C1-C4-alkyl, C1-C4 alkoxy, or halo, R3 is C1-C5 alkyl, X is â€”NR4R5 or â€”OR7, R4 and R5 are independently H, C1-C5 alkyl, or R4 and R5 together with the nitrogen to which they are both bound form: R6 is â€”(CH2)n-phenyl, wherein the phenyl is unsubstituted or substituted with C1-C4 alkyl, C1-C4 alkoxy, or halo, A and B are independently â€”COâ€” or â€”CH2â€”, provided that A and B are not both â€”COâ€”, R7 is C1-C5 alkyl, Z is â€”CH2â€”, â€”Oâ€”, â€”Sâ€”, or â€”N(R8)â€”, R8 is H or C1-C6 alkyl, and n is 1 or 2.