Patent ID: 6224905
Filing Date: 2001-05-01
Classification: A61K

Abstract:
A process for the preparation of a solid rapidly disintegrating dosage form comprising a porous network of matrix forming materials, wherein said matrix forming materials comprisei) a water-soluble, hydratable gel or foam-forming material,ii) a rigidifying agent for the gel or foam-forming material and optionallyiii) one or more amino acids andwhich process comprises:overfilling a mold with a predetermined amount of an aqueous composition comprising the matrix forming materials so that a convex meniscus is created on top of the mold;freezing the aqueous composition in the mold; andremoving the solvent from the frozen composition by subjecting it to lyophilization or to solid state dissolution, thus leaving a porous network of matrix forming materials;characterized in that the shape of the bottom surface of the mold is a mirror-image of the shape of the frozen meniscus on the top, the mirror-plane being parallel to the plane defined by the rim of the mold, thus yielding a dosage form shaped as a biconvex tablet having symmetrical top and bottom surfaces.