Patent ID: 9034381
Filing Date: 2015-05-19
Classification: A61K

Abstract:
1. A multi-stage process to control the particle size of a pharmaceutical substance comprising the steps of: passing an initial feedstock of the pharmaceutical substance through a first stage of the multi-stage particle size reduction process, the first stage having a first set of particle size control parameters to obtain a further feedstock for at least a second stage of the multi-stage particle size reduction process; passing the further feedstock through the second stage of the multi-stage particle size reduction process, the second stage having a second set of particle size control parameters to obtain a pharmaceutical substance with a reduced median particle size and narrower distribution of median particle size than the further feedstock; and collecting the pharmaceutical substance of the final stage of the multi-stage particle size reduction process with a median particle size greater than 10 μm and with a narrow reproducible distribution of median particle size, wherein at least 50% of the particles of the pharmaceutical substance of the final stage have a particle size deviating no more than between 1 μm and 10 μm from the median particle size.