Patent ID: 6372751
Filing Date: 2002-04-16
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of the following formulae: wherein:Z1 is â€”N(R7)â€”, â€”CH2Oâ€” or â€”S(O)nâ€” (where n is 0 to 2); Z2 is â€”Oâ€”, â€”N(R7)â€”, â€”OCH2â€” or â€”S(O)nâ€” (where n is 0 to 2); R1 and R4 are each independently hydrogen, halo, alkyl, nitro, â€”OR7, â€”C(O)OR7, â€”C(O)N(R7)R8, â€”N(R7)R8, â€”N(R7)C(O)R7, or â€”N(H)S(O)2R9; R2 is â€”C(NH)NH2, â€”C(NH)N(H)OR7, â€”C(NH)N(H)C(O)OR9, â€”C(NH)N(H)C(O)R7, â€”C(NH)N(H)S(O)2R9, or, â€”C(NH)N(H)C(O)N(H)R7; R3 is hydrogen, halo, alkyl, haloalkyl, nitro, ureido, guanidino, â€”OR7, â€”C(NH)NH2, â€”C(NH)N(H)OR7, â€”C(O)N(R7)R8, â€”R10â€”C(O)N(R7)R8, â€”CH(OH)C(O)N(R7)R8, â€”N(R7)R8, â€”R10â€”N(R7)R8, â€”C(O)OR7, â€”R10â€”C(O)OR7, â€”N(R7)C(O)R7, (1,2)-tetrahydropyrimidinyl (optionally substituted by alkyl), (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl); R5 is hydrogen, halo, alkyl, haloalkyl, nitro, aralkoxy, â€”OR9, â€”R10â€”OR9, â€”N(R7)R8, â€”C(O)OR7, â€”R10â€”C(O)OR7, â€”C(O)N(R7)R8, â€”R10â€”C(O)N(R7)R8, â€”C(O)N(R7)CH2C(O)N(R7)R8, â€”N(R7)C(O)N(R7)R8, â€”N(R7)C(O)R8, â€”N(R7)S(O)2R9, or â€”N(R7)C(O)N(R7)â€”CH2C(O)N(R7)R8; R6 is aryl (optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), aralkyl (wherein the aryl is optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), heterocyclyl (optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or heterocyclylalkyl (wherein the heterocyclyl is optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); each R7 and R8 is independently hydrogen, alkyl, aryl (optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (wherein the aryl is optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); each R9 is alkyl, aryl (optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (wherein the aryl is optionally substituted by halo, haloalkyl, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), and each R10 is independently an alkylene or alkylidene chain; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.