Patent ID: 6465463
Filing Date: 2002-10-15
Classification: A61K,A61P

Abstract:
A method of reducing mortality associated with heart failure, for improving the oxygen consumption, for improving the quality of life or for improving exercise tolerance in a black patient comprising administering to the black patient a therapeutically effective amount of at least one hydralazine compound of Formula (I) or a pharmaceutically acceptable salt thereof, and at least one of isosorbide dinitrate and isosorbide mononitrate,wherein the hydralazine compound of Formula (I) is wherein a, b and c are each independently a single or a double bond; R1 and R2 are each independently a hydrogen, an alkyl, an ester or a heterocyclic ring; R3 and R4 are each independently a lone pair of electrons or a hydrogen, with the proviso that at least one of R1, R2, R3 and R4 is not a hydrogen.