Patent ID: 6174874
Filing Date: 2001-01-16
Classification: A61P,C07F,H04M,H04Q

Abstract:
A compound represented by formula I: ##STR117##or a pharmaceutically acceptable salt thereof, wherein:R.sup.1 is selected from the group consisting of:C.sub.1-10 alkyl(R.sup.a).sub.0-7, C.sub.2-10 alkenyl(R.sup.a).sub.0-7, (R.sup.a).sub.0-7 and Het(R.sup.a).sub.0-7 ;R.sup.2 is selected from the group consisting of C.sub.1-6 alkyl(R.sup.a).sub.0-7, Aryl(R.sup.a).sub.0-7 and Het(R.sup.a).sub.0-7 ;wherein, each R.sup.a independently represents a member selected from the group consisting of: Aryl, OH, halo, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, OC.sub.1-10 alkyl, S(O).sub.y C.sub.1-6 alkyl, S(O).sub.y NR.sup.3' R.sup.4', Het and --P(O)(OH).sub.2 wherein y is 0, 1, or 2;Y.sup.1 and Y.sup.2 represent --(CR.sup.3 R.sup.4).sub.a --X--(CR.sup.3 R.sup.4).sub.b -- wherein a and b are integers 0-1 such that the sum of a and b equals 0, 1 or 2,X represents a bond, O, S(O).sub.y, NR.sup.3', C(O), OC(O), C(O)O, C(O)NR.sup.3', NR.sup.3' C(O) or --CH.dbd.CH--, where y is as previously defined;and R.sup.3 and R.sup.4 are independently H, halo, C.sub.1-10 -alkyl or haloC.sub.1-10 alkyl, or R.sup.3 and R.sup.4 taken together with any intervening atoms represent a 3-7 membered ring;R.sup.3' is selected from the group consisting of: H, C.sub.1-6 alkyl, haloC.sub.1-6 alkyl, OH, C(O)C.sub.1-6 alkyl, C(O)Aryl, C(O)Het, C(O)C.sub.1-6 haloalkyl, Aryl and Het;R.sup.4' is selected from the group consisting of: H, C.sub.1-6 alkyl, haloC.sub.1-6 alkyl, Aryl and Het;Z.sup.1 and Z.sup.2 each independently represent --(CR.sup.3 R.sup.4).sub.a --X--(CR.sup.3 R.sup.4).sub.b -- wherein X, a, b, R.sup.3 and R.sup.4 are as defined, or Z.sup.1 and Z.sup.2 are taken in conjunction with R.sup.1 and R.sup.2 and represent in combination ##STR118##wherein R.sup.1 and R.sup.2 represent carbonyl groups, or Z.sup.1 and Z.sup.2 together are --CH.sub.2 NR.sup.1 C(O)NR.sup.2 CH.sub.2 --, with R.sup.1 and R.sup.2 as originally defined;W.sup.1 and W.sup.2 are each independently selected from the group consisting of: H, OH, CN, halo, OC.sub.1-6 alkyl(R.sup.a).sub.0-7, S(O).sub.y C.sub.1-6 alkyl(R.sup.a).sub.0-7, with y equal to 0-2, S(O).sub.3 H, CN, C.sub.1-6 alkyl(R.sup.a).sub.0-7, N.sub.3, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl(R.sup.a).sub.0-7, CO.sub.2 C.sub.2-6 alkenyl(R.sup.a).sub.0-7, C(O)C.sub.1-6 alkyl(R.sup.a).sub.0-7, C(O)NR.sup.3' R.sup.4', S(O).sub.y NR.sup.3' R.sup.4', NR.sup.3' R.sup.4' and Het, wherein R.sup.3' and R.sup.4' are as defined above; orthe two W.sup.1 groups taken in combination represent a fused phenyl ring;Aryl represents a 6-14 membered aromatic ring system;and Het represents a 5-10 membered aromatic ring system containing 1-4 heteroatoms, 0-4 of which are N atoms and 0-1 of which are O or S(O).sub.y wherein y is as previously defined, and 0-2 carbonyl groups.