Patent ID: 8454959
Filing Date: 2013-06-04
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating or alleviating an immune disease in a human individual in need of such treatment, comprising administering to the individual a therapeutically effective amount of a pharmaceutical composition comprising an isolated antibody polypeptide that binds the same epitope as domain antibody (dAb) 1h-239-891(D70C) (SEQ ID NO: 543), wherein said antibody polypeptide comprises a variable domain having a binding specificity to CD28 and at least 90% sequence identity to the amino acid sequence of dAb 1h-239-891(D70C) (SEQ ID NO: 543), wherein the immune disease is prevented, treated, or alleviated, and wherein the immune disease is a graft-related disease.