Patent ID: 6143789
Filing Date: 2000-11-07
Classification: A61P,C07B,C07C,C07D

Abstract:
A compound selected from those of formula (I): ##STR26## wherein: A and B together form a naphthalene or tetrahydronaphthalene group,T represents alkylene having two carbon atoms,R represents hydrogen, hydroxy, R' or OR', R' representing optionally substituted linear or branched (C.sub.1-C.sub.6)alkyl, optionally substituted linear or branched (C.sub.2 -C.sub.6)alkenyl, optionally substituted linear or branched (C.sub.2 -C.sub.6)alkynyl, optionally substituted (C.sub.3 -C.sub.7)cycloalkyl, optionally substituted (C.sub.4 -C.sub.7)-cycloalkenyl, linear or branched trihalo(C.sub.1 -C.sub.6)alkylsulphonyl, optionally substituted aryl, optionally substituted biphenyl, or optionally substituted heteroaryl,G.sub.1 represents halogen (and in that case is bonded to any of the junctions of the B ring), linear or branched trihalo(C.sub.1 -C.sub.6)alkylsulphonyloxy, carboxy, formyl, cyano, or R.sub.1, R.sub.1 representing optionally substituted aryl, optionally substituted biphenyl or optionally substituted heteroaryl,G.sub.2 represents a group selected from: ##STR27## wherein: X represents oxygen or sulphur,R.sub.2 represents hydrogen,R.sub.21 represents optionally substituted linear or branched (C.sub.1 -C.sub.6)alkyl, optionally substituted linear or branched (C.sub.2 -C.sub.6)alkenyl, optionally substituted linear or branched (C.sub.2 -C.sub.6)alkynyl, optionally substituted (C.sub.3 -C.sub.7)cycloalkyl, optionally substituted heteroaryl, optionally substituted aryl, or optionally substituted biphenyl,with the proviso that:when G.sub.2 represents G.sub.22, then G.sub.1 represents linear or branched trihalo (C.sub.1 -C.sub.6)alkylsulphonyloxy, or optionally substituted heteroaryl different from pyridyl,when A and B together form a tetrahydronaphthalene group, G.sub.1 is bonded in the 3- or 4-position of that ring structure,when T represents ethylene and G.sub.2 represents G.sub.21 wherein X represents sulphur, then R.sub.21 is other than optionally substituted aryl,the term ""aryl"" denoting phenyl or naphthyl,the term ""heteroaryl"" denoting mono- or bi-cyclic group having 4 to 11 ring members, being saturated or unsaturated and containing 1 to 4 hetero atoms selected from nitrogen, oxygen, and sulphur,it being understood that:the term ""optionally substituted"" applied to the terms ""alkyl"", ""alkenyl"", ""alkynyl"", ""cycloalkyl"" and ""cycloalkenyl"" means that those groups are substituted by one or more halogen, and/or (C.sub.3 -C.sub.7)cycloalkyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, optionally substituted aryl, and/or optionally substituted heteroaryl,the term ""optionally substituted"" applied to the terms ""aryl"", ""biphenyl"" and ""heteroaryl"" means that those groups are substituted by one or more halogen, linear or branched (C.sub.1-C.sub.6)alkyl, linear or branched trihalo(C.sub.1 -C.sub.6)alkyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, and/or nitro, and/or amino (optionally substituted by one or two identical or different linear or branched (C.sub.1 -C.sub.6)alkyl), and/or cyano, carboxy and/or linear or branched (C.sub.1 -C.sub.6)alkylcarbonyl, and/or aminocarbonyl (optionally substituted by one or two identical or different linear or branched (C.sub.1 -C.sub.6)-alkyl),their enantiomers, diastereoisomers, and pharmaceutically-acceptable acid or base addition salts thereof.