Patent ID: 6893869
Filing Date: 2005-05-17
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A host cell infected with a composition comprising a first recombinant virus which has incorporated into the non-essential region of a viral genome or portion thereof one or more genes or portion thereof encoding a tumor associated antigen or an antigen of a pathogenic microorganism and a second recombinant virus which has incorporated into the non-essential region of a viral genome or portion thereof one or more genes or portion thereof encoding B7-2 or B7-1 and B7-2 alone or in combination with an exogenous immunostimulatory molecule, chemotherapeutic drug, antibiotic, antiviral drug or antifungal drug, the composition being able to coinfect the host cell resulting in coexpression of genes encoding the tumor associated antigen or antigen of a pathogenic microorganism and genes encoding B7-2, or B7-1 and B7-2.