Patent ID: 6693137
Filing Date: 2004-02-17
Classification: C07C,C07D

Abstract:
A compound of the formula: wherein:La represents (1-4C)alkylene; Lb represents (1-4C)alkylene; Lc represents (1-4C)alkylene; r is zero or 1; m is zero or 1; n is zero; q is 1 or 2; X1 represents O or CONH; X2 represents O, S, NR10, C(&boxH;O), OCO, COO, NHCO2, O2CNH, CONH, NHCO, SO or SO2; X3 represents O, S, NR11, C(&boxH;O), NHCO2, O2CNH, CONH, NHCO, SO or SO2; R1 represents a hydrogen atom, a (1-4C)alkyl group, a (3-8C)cycloalkyl group, an optionally substituted aromatic group, an optionally substituted heteroaromatic group, or a saturated 4 to 7 membered heterocyclic ring containing the group NR10 and a group X as the only hetero ring members, wherein X represents â€”CH2â€”, CO, O, S or NR12 and R12 represents hydrogen or (1-4C); R9 is hydrogen or (1-4C)alkyl; R10 is hydrogen or (1-4C)alkyl, or R1 and R10 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, 4-di(1-4C)alkylaminopiperidinyl, morpholino, piperazinyl or N-(1-4C)alkylpiperazinyl group; R11 is hydrogen or (1-4C)alkyl; R2 represents 2-propyl; R5, R6 and R7 each represent hydrogen; R8 represents methyl; or a pharmaceutically acceptable salt thereof,provided that (1) if m represents zero, then X1 represents CONH, X2 represents NR10 and R1 and R10 together with the nitrogen atom to which they are attached form an azetidinyl, piperidinyl, 4-di(1-4C)alkylaminopiperidinyl, piperazinyl or N-(1-4C)alkylpiperazinyl group, and (2) if the groupâ€”X2â€”(La)mâ€”(X3Lc)râ€”X1â€”(Lb)nâ€”represents â€”OCH2CONHâ€”, then R1 does not represent an optionally substituted aromatic group or an optionally substituted heteroaromatic group.