Patent ID: 7153933
Filing Date: 2006-12-26
Classification: A61K,A61P,C07K,Y02P

Abstract:
1. A solid phase synthesis method for preparing a peptide-PEG-phospholipid conjugate, which comprises the steps of: (1) synthesizing an amino acid residue protected peptidyl resin in solid phase; (2) conjugating a PEG and a phospholipid to the peptidyl resin to form a peptide-PEG-phospholipid resin; (3) cleaving the peptide-PEG-phospholipid resin to obtain a peptide-PEG-phospholipid; (4) removing at least one side chain protecting group from at least one amino acid of the peptide-PEG-phospholipid, thereby forming a peptide-PEG-phospholipid conjugate; and (5) optionally modifying the peptide portion of the peptide-PEG-phospholipid conjugate to a cyclic form after any of the foregoing steps (1)–(4); wherein the PEG is conjugated to each of the peptidyl resin and the phospholipid by a single amide bond.