Patent ID: 9046292
Filing Date: 2015-06-02
Classification: A01N,F25D,Y10T

Abstract:
1. A method for monitoring the thawing of a frozen biopharmaceutical material contained in a biocontainer, the method comprising of: providing said frozen biopharmaceutical material in a sterilized biocontainer of a predetermined volumetric capacity comprising an indicator to indicate whether the biopharmaceutical material was properly thawed, a storage element, and a sensor attachment mechanism affixed to opposite edges of said biocontainer, disposed within said biocontainer and passing through the geometric center of said biocontainer, said sensor attachment mechanism comprising a sealed enclosure holding a wireless temperature sensor, said wireless temperature sensor positioned at or about the geometric center of said biocontainer; removing said biocontainer from a freezer such that said biopharmaceutical material thaws; taking a plurality of measurements of the temperature of said frozen biopharmaceutical material within said biocontainer at or about the geometric center as said frozen biopharmaceutical material thaws; storing said plurality of measurements on said storage element; allowing said frozen biopharmaceutical material to completely thaw; comparing said plurality of measurements to a reference temperature profile; determining whether the difference between said plurality of measurements and said reference temperature profile indicates that the frozen biopharmaceutical material, once thawed, has been properly thawed; and actuating said indicator to indicate the result of said determination of whether said biopharmaceutical material was properly thawed.