Patent ID: 6639062
Filing Date: 2003-10-28
Classification: C07H,Y02P

Abstract:
A compound of the structure: wherein:T4 is Bx or Bxâ€”L where Bx is a heterocyclic base moiety; one of T1, T2 and T3 is L, hydrogen, hydroxyl, a protected hydroxyl or a sugar substituent group; another one of T1, T2 and T3 is L, hydroxyl, a protected hydroxyl, a connection to a solid support or an activated phosphorus-containing substituent group; the remaining one of T1, T2 and T3 is L, hydrogen, hydroxyl or a sugar substituent group provided that at least one of T1, T2, or T3 is L or Bxâ€”L; said group L having one of the formulas; â€ƒwherein: each m and mm is, independently, from 1 to 10; y is from 1 to 10; E is N(R1)(R2) or N&boxH;C(R1)(R2); each R1 and R2 is, independently, H, a nitrogen protecting group, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, wherein said substitution is OR3, SR3, NH3+, N(R3)(R4), guanidino or acyl where said acyl is â€”C(&boxH;O)N(R3)(R4), â€”C(&boxH;O)R3, or â€”C(&boxH;O)OR3; provided that when T4 is Bx-L, R1 and R2 are not both H; or R1 and R2, together, are a nitrogen protecting group or are joined in a ring structure that optionally includes an additional heteroatom selected from N and O; and each R3 and R4 is, independently, H, C1-C10 alkyl, a nitrogen protecting group, or R3 and R4, together, are a nitrogen protecting group; or R3 and R4 are joined in a ring structure that optionally includes an additional heteroatom selected from N and O.