Patent ID: 6498196
Filing Date: 2002-12-24
Classification: C07C,C07D,C07F

Abstract:
A compound represented by formula (1) and pharmaceutically acceptable derivatives thereof;wherein;Z is S, X is â€”CR7R8â€” wherein R7 and R8 are independently selected from the group consisting of H, OH, halogen, CN, COOH, CONH2, amino, nitro, SH, C1-6alkyl where one or more of the carbon atoms in said C1-6alkyl may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6 alkenyl where one or more of the carbon atoms in said C2-6 alkenyl may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkynyl where one or more of the carbon atoms in said C2-6alkynyl may optionally be substituted by one or more heteroatoms selected from O, S and N; and COORc wherein Rc is C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R1 is selected from the group consisting of H, C1-12alkyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-12alkenyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-12alkynyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C6-12 aryl, C6-12 aralkyl, C6-12 aryloxy, and C1-2 acyl; R2 and R3 are independently selected from the group consisting of C1-6 alkyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkenyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkynyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C6-12 aryl, C6-12 aralkyl, and H; R4 and R5 are independently selected from the group consisting of C1-6 alkyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkenyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkynyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, and H; R6 is hydrogen, OH, C1-6 alkyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkenyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, C2-6alkynyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, Oâ€”C1-6 alkyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, Oâ€”C2-6alkenyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, Oâ€”C2-6alkynyl where one or more of the carbon atoms may optionally be substituted by one or more heteroatoms selected from O, S and N, halogen, CN, COOH, CONH2, amino, nitro, or SH; with the provisos that: 1) not both R4 and R5 are H; and 2) at least one of R2 and R3 is H or C1-6alkyl.