Patent ID: 6525051
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of the following formulae: wherein:each Z1 is independently â€”(CH2)mâ€”Oâ€” (where m is 0 to 2), â€”(CH2)mâ€”Sâ€” (where m is 0 to 2), or â€”(CH2)mâ€”N(R7)â€” (where m is 0 to 2); each Z2 is independently â€”Oâ€”(CH2)mâ€” (where m is 0 to 2), â€”Sâ€”(CH2)mâ€” (where m is 0 to 2), or â€”N(R7)â€”(CH2)mâ€” (where m is 0 to 2); Z3 is â€”(CH2)nâ€” (where n is 1 to 4), â€”Oâ€”(CH2)mâ€” (where m is 0 to 2), â€”Sâ€”(CH2)mâ€” (where m is 0 to 2), or â€”N(R7)â€”(CH2)mâ€” (where m is 0 to 2); each R1 and R3 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, nitro, aralkoxy, â€”OR8, â€”R11â€”OR8, â€”N(R8)R9, â€”C(O)OR8, â€”R11â€”C(O)OR8, â€”C(O)N(R8)R9, â€”R11â€”C(O)N(R8)R9, â€”C(O)N(R8)CH2C(O)N(R8)R9, â€”N(R8)C(O)N(R8)R9, â€”N(R8)C(O)R9, â€”N(R8)S(O)2R10, and â€”N(R8)C(O)N(R8)â€”CH2C(O)N(R8)R9; R2 is hydrogen, alkyl, bromo, iodo, â€”N(R7)â€”(CH2)pâ€”N(R8)R9 (where p is 1 to 4), â€”(CH2)qâ€”N(R7)â€”CH2â€”C(O)â€”OR8 (where q is 0 to 3), 4-morpholinyl, 1-piperidinyl, 1-piperazinyl, or 1-pyrrolidinyl; each R4 is independently hydrogen or alkyl; each R5 is independently hydrogen, halo, haloalkyl, alkyl, nitro, â€”OR8, â€”C(O)OR8, â€”C(O)N(R8)R9, â€”N(R8)R9, â€”N(R8)C(O)R8, or â€”N(H)S(O)2R10; each R6 is independently hydrogen, alkyl, aryl, aralkyl, halo, â€”N(R8)R9, â€”N(R7)â€”(CH2)pâ€”N(R8)R9 (where p is 1 to 4), â€”(CH2)qâ€”N(R7)â€”CH2â€”C(O)OR8 (where q is 0 to 3), 4-morpholinyl, 1-piperidinyl, 1-piperazinyl, or 1-pyrrolidinyl; each R7 is hydrogen or alkyl; each R8 and R9 is independently hydrogen, alkyl, aryl (optionally substituted by one or more substituents selected from the group consisting of halo, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, and dialkylaminocarbonyl), or aralkyl (wherein the aryl is optionally substituted by one or more substituents selected from the group consisting of halo, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, and dialkylaminocarbonyl); each R10 is alkyl, aryl (optionally substituted by one or more substituents selected from the group consisting of halo, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, and dialkylaminocarbonyl), or aralkyl (wherein the aryl is optionally substituted by one or more substituents selected from the group consisting of halo, alkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, dialkylamino, monoalkylamino, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, and dialkylaminocarbonyl), and each R11 is independently an alkylene or alkylidene chain; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.