Patent ID: 6380194
Filing Date: 2002-04-30
Classification: A61P,C07D

Abstract:
A compound of formula a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, whereinR1 and R2 are each independently selected from hydrogen; hydroxy; amino; C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)aminocarbonyl; dihydro-2(3H)-furanone; C1-6alkyl substituted with one or two substituents each independently selected from amino, imino, aminocarbonyl, aminocarbonylamino, hydroxy, hydroxyC1-6alkyloxy, carboxyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl and thienyl; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)aminoC1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R5 and R7 are each independently selected from hydrogen, hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; R4 and R8 are hydrogen; R6 is cyano; L is C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; or L is C1-10alkyl substituted with one or two substituents independently selected from C3-7cycloalkyl; indolyl or indolyl substituted with one, two, three or four substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, C1-6alkylcarbonyl; phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, hydroxy, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, C1-6alkylcarbonyl; and, Ar1 is phenyl, or phenyl substituted with one, two or three substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, cyano, nitro or trifluoromethyl Co.No.AlkR1/R2R3R4R5R6R7R8a1-(4-(2-H/HHCH3HHHHmethylpropyl)-phenyl)ethylb1-(4-(2-H/HHHHNO2HHmethylpropyl)-phenyl)ethylc1-(4-(2-H/HC6H5HHHHHmethylpropyl)-phenyl)ethyld1-(4-(2-H/HHNO2HCH3HHmethylpropyl)-phenyl)ethyle1-(4-(2-H/HHHHNH2HHmethylpropyl)-phenyl)ethylf4-(2-H/HHHCF3HHHmethylpropyl)-phenylmethylg1-(4-(2-H/HHHHClHHmethylpropyl)-phenyl)ethylh4-(2-H/HHHHHHHmethylpropyl)-phenylmethyli3,4-H/HHHHHHHdimethoxy-phenylmethylj2,3-H/HHHHHHHdimethoxy-phenylmethylk3,4-diethoxy-H/HHHHHHHphenylmethyll2-(3,5-(1,1-H/HHHHHHHdimethylethyl)-4-hydroxy-phenyl)ethylm2-(3,5-(1,1-H/HHHt-BuOHt-BuHdimethylethyl)-4hydroxy-phenyl)ethylnphenylmethylH/HHCH3HHHHophenylmethylH/HHHHHHâ€‰H.