Patent ID: 6107316
Filing Date: 2000-08-22
Classification: A61K,A61P,Y02A

Abstract:
A method for treating protozoal infections in an animal comprising applying to the locus of a protozoan a compound having the formula: ##STR10## wherein; A is selected from substituted and unsubstituted phenyl, pyridyl, furyl, thionyl, isoxazolyl, oxazolyl, pyrrolyl, isothiazolyl, thiazolyl, pyrazolyl, imidazolyl, pyrimidinyl, quinolyl, isoquinolyl, naphthyl, pyridazinyl, pyrazinyl, benzothienyl, indolyl, benzofuranyl, benzyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, halo(C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, and halo(C.sub.2 -C.sub.6)alkynyl wherein the substituents are independently selected from:a) one to four of halo, cyano, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, halo(C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, halo(C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkoxy, halo(C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio, halo(C.sub.1 -C.sub.6)alkylthio, nitro, --NR.sup.6 R.sup.7, --CR.sup.8 .dbd.NOR.sup.9, NHCOOR.sup.10, --CONR.sup.11 R.sup.12, COOR.sup.13 ;b) fused five, six, and seven membered rings formed from two such substituents; andc) a fused 5, 6 or 7 membered carbocyclic ring which may contain up to two heteroatoms selected from the group consisting of: O, S, N, and P:R.sup.1 and R.sup.2 are each independently selected from H, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, halo(C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, or halo(C.sub.2 -C.sub.6)alkynyl provided that at least one of R.sup.1 and R.sup.2 is other than H;R.sup.6 and R.sup.7 are each independently selected from H, (C.sub.1 -C.sub.6)alkyl, and (C.sub.1 -C.sub.6)alkylcarbonyl,R.sup.8 is selected from H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, and (C.sub.2 -C.sub.6)alkynyl;R.sup.9 is selected from H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, and (C.sub.1 -C.sub.4)alkylcarbonyl;R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are each independently selected from H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, and (C.sub.2 -C.sub.6)alkynyl; and X, Y and Z are each independently selected from H, halo, cyano, thiocyano, isothiocyano and (C.sub.1 -C.sub.6)alkylsulfonyloxy, provided that at least one of X, Y and Z is halo, cyano, thiocyano, isothiocyano or (C.sub.1 -C.sub.6)alkylsulfonyloxy;enantiomers and stereoisomers thereof; and physiologically acceptable acid addition salts thereof.