Patent ID: 7674803
Filing Date: 2010-03-09
Classification: A61P,C07D

Abstract:
1. A compound, which is N-ethyl-N-(1-methyl-2-oxo-2-phenylethyl) 2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carbamate; N-ethyl-N-(1-methyl-2-oxo-2-pyrid-3-ylethyl) 2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carbamate; N-ethyl-N-(1-methyl-2-oxo-2-phenylethyl) 2-[1-(6-methyl-4′-trifluoromethoxybiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carbamate; N-ethyl-N-(1-methyl-2-oxo-2-pyrid-2-ylethyl) 2[1-(6-methyl-4′-trifluoro-methoxybiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carbamate; N-[cyano(4-fluorophenyl)methyl]-N-phenyl-2-[1-(4′-trifluoromethyl-biphenyl-2-carbony)piperid-4-yl]thiazole-4-carboxamide; N-(α-cyanobenzyl)-N-ethyl-2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)-piperid-4-yl]thiazole-4-carboxamide; 2-{1-{4′(trifluoromethyl)-1,1′-biphenyl-2-yl]carboxyl}piperid-4-yl}-1,3-thiazole-4-carboxylic acid; 1-(4-{4-(3-hydroxypiperid-1-yl)methanoyl]thiazol-2-yl}piperid-1-yl)-1-(4′-trifluoromethylbiphenyl-2-yl)methanone; N-methyl-N-(1-methyl-2-oxo-2-phenethyl)-2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carboxamide; N-methyl-N-(1-methyl-2-oxo-2(S)-phenethyl)-2-[1-(4′-trifluoromethyl-biphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carboxamide; N-(7-oxo-7H-thieno[3,2-b]pyran-6-yl)-2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carboxamide; N-(2-methyl-4-oxo-4H-chromen-3-yl)-2-[1-(6-methyl-4′-trifluoromethoxybiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carboxamide; N-(α-cyanobenzyl)-N-isopropyl-2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)-piperid-4-yl]thiazole-4-carboxamide; or N-[1-cyano-1-(pyrid-4-yl)methyl)-N-isopropyl-2-[1-(4′-trifluoromethylbiphenyl-2-carbonyl)piperid-4-yl]thiazole-4-carboxamide; or a pharmaceutically acceptable salt thereof, or an optical isomer thereof, or an N-oxide or S-oxide form thereof.