Patent ID: 6339097
Filing Date: 2002-01-15
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I in which X is O or S;R1 and R2, which may be identical or different, are hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl, or alternatively R1 and R2, together with the carbon atom bearing them, form (C3-C8)cycloalkyl; R3 is a (C6-C12)aryl optionally substituted with one or more Y radicals, which may be identical or different; Y is halogen, a (C1-C6)alkyl optionally substituted with one or more halogens, a (C1-C6)alkoxy optionally substituted with one or more halogens, a (C1-C6)alkylthio optionally substituted with one or more halogens, (C1-C7)acylamino, (C1-C3)acyloxy, hydroxyl, nitro, cyano, amino, (C1-C6)alkylamino, di-(C1-C6)alkylamino, pyrrolidono, piperidino, morpholino, (C1-C4)alkylsulfonylamino, (C2-C5)alkoxycarbonyl, carboxyl, (C2-C6)alkylcarbonyl, carbamoyl, (C2-C5)alkylcarbamoyl, di-(C2-C5)alkylcarbamoyl or (C1-C6)alkyl-sulfonyl; R4 and R5, which may be identical or different, are a Y radical or alternatively a hydrogen atom; Ar is one of the following groups B or C: T1 and T2, which may be identical or different, are halogen, (C1-C6)alkoxy, (C1-C6)alkylthio or (C1-C6)alkyl; T is a hydrogen atom or (C1-C6)alkyl; T3 and T4, which may be identical or different, are (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C6-C12)arylthio, (C1-C6)alkoxycarbonyl, (C1-C6)alkylcarbonyl, (C6-C12)arylcarbonyl or â€”(CH2)pâ€”OR in which p is 1, 2, 3 or 4 and R is (C2-C3)alkyl, R6 and R7 are each a hydrogen atom or alternatively R6 and R7 together are a bond; Z is either (i) the divalent group â€”CHR9â€” in which R9 is a hydrogen atom or (C1-C6)alkyl; or (ii) the divalent group â€”CHR10â€”CHR11â€” in which R10 and R11 together form a bond such that Z is â€”CH&boxH;CHâ€” or alternatively R10 and R11, which may be identical or different, are as defined above for R9; or (iii) the divalent group â€”CHR12â€”CHR13â€”CH2â€” in which R12 and R13 together form a bond such that Z is â€”CH&boxH;CHâ€”CH2â€”, or alternatively R12 and R13, which may be identical or different, are as defined above for R9, as well as its addition salts with a pharmaceutically acceptable acid or base.