Patent ID: 6951873
Filing Date: 2005-10-04
Classification: A61K

Abstract:
1. A method of treating an age-related behavioral disorder in a companion animal comprising administering to a companion animal in need of such treatment a therapeutically effective amount of a compound of Formula I, wherein R 1 and R 2 are each independently selected form the group consisting of hydrogen; (C 1 -C 6 ) alkoxy; benzyloxy; phenoxy; hydroxy; phenyl; benzyl; halo; nitro; cyano; —COR 5 ; —COOR 5 ; —CONHR 5 ; —NR 5 R 6 ; —NR 5 COR 6 ; —OCONR 5 R 6 ; —NHCOOR 5 ; (C 1 -C 6 ) alkyl which may be substituted with from 1 to 3 fluorine atoms; SO p CH 2 -phenyl or SO p (C 1 -C 6 ) alkyl, wherein p is 0, 1 or 2; pyridylmethyloxy or thienylmethyloxy; 2-oxazolyl; 2-thiazolyl; and benzenesulfonamide; wherein the phenyl moieties of said phenoxy, benzyloxy, phenyl, benzyl and benzenesulfonamide groups, the pyridyl and thienyl moieties of said pyridylmethyloxy or thienylmethyloxy groups, and the oxazolyl and thiazolyl moieties of said 2-oxazolyl and 2-thiazolyl groups may be substituted with 1 or 2 substituents independently selected from the group consisting of halo, (C 1 -C 4 ) alkyl, trifluoromethyl, (C 1 -C 4 ) alkoxy, cyano, nitro and hydroxy; or R wherein R 3 is hydrogen or (C 1 -C 6 ) alkyl; J is oxygen, sulfur or NR 4 ; R 4 is hydrogen or (C 1 -C 4 ) alkyl; and Q is oxygen, sulfur, NH, CHCH 3 , C(CH 3 ) 2 , —CH═CH—, or (CH 2 ) I wherein I is an integer from 1 to 3; X is oxygen or sulfur; Y is —(CH R L is phenyl, phenyl-(C wherein b is an integer from 1 to 4; R 9 and R 10 are independently selected from the group consisting of hydrogen, (C 1 -C 4 ) alkyl, halo, and phenyl; E and F are independently —CH— or nitrogen; and G is oxygen, sulfur or NR 4 , with the proviso that when E and F are both nitrogen, one of R 9 and R 10 is absent; and R or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier.