Patent ID: 7892737
Filing Date: 2011-02-22
Classification: C07H,C12Q

Abstract:
1. A method comprising modulating the T m of a PNA oligomer/NA complex, comprising covalently linking, directly or indirectly, to the PNA oligomer, comprising an N-terminal amine group and a C-terminal carbonyl carbon, at least one modifying moiety selected from an alkyl group, an alkenyl group, an alkynyl group, a heteroalkyl group, a heteroalkenyl group, a heteroalkynyl group and a heterocyclohydrocarbon group to the N-terminal amine group and/or to the C-terminal carbonyl carbon of the PNA oligomer used to form the PNA oligomer/NA complex, provided that the group is not an acetyl group or a side chain of a terminally linked natural amino acid, to thereby obtain a PNA oligomer/NA complex having the T