Patent ID: 6080856
Filing Date: 2000-06-27
Classification: C07C,C07D

Abstract:
A method for making a compound of Formula I ##STR17## wherein R.sup.1 is F, Cl, or C.sub.1 -C.sub.3 fluoroalkoxy and R.sup.2 is C.sub.1 -C.sub.3 alkyl; comprising(a) reacting a compound of Formula IV ##STR18## wherein R.sup.1 is F, Cl, or C.sub.1 -C.sub.3 fluoroalkoxy,R.sup.2 is C.sub.1 -C.sub.3 alkyl, andR.sup.3 is the protecting group CO.sub.2 CH.sub.2 (C.sub.6 H.sub.5); with di(C.sub.1 -C.sub.3 alkoxy)methane in the presence of a Lewis acid, to form a compound of Formula V ##STR19## (b) hydrogenating the compound of Formula V to make a compound of Formula VI ##STR20## wherein R.sup.1 is F, Cl, or C.sub.1 -C.sub.3 fluoroalkoxy and R.sup.2 is C.sub.1 -C.sub.3 alkyl; and(c) reacting the compound of Formula VI with a compound of Formula VII ##STR21##