Patent ID: 6277877
Filing Date: 2001-08-21
Classification: C07D

Abstract:
An intermediate of Formula QZ ##STR10##whereinR.sub.5 is H;R.sub.4 is phenylmethyl, thien-2- or -3-ylmethyl, fur-2- or -3-ylmethyl wherein said rings are optionally mono- or di-substituted with fluoro; andR.sub.12 is thiazolidin-3-yl, 1-oxothiazolidin-3-yl, 1,1-dioxothiazolidin-3-yl, pyrrolidin-1-yl, piperidin-1-yl, azetidin-1-yl, 1,2-oxazinan-2-yl, isoxazolidin-2-yl, isothiazolidin-2-yl, 1,2-oxazetidin-2-yl or oxazolidin-3-yl,wherein said R.sub.12 rings are mono- or di-substituted independently with halo, (C.sub.1 -C.sub.5)alkyl, (C.sub.1 -C.sub.5)alkoxy, hydroxy, amino, mono-N-- or di-N,N--(C.sub.1 -C.sub.5)alkylamino, formyl, carbamoyl, mono-N-- or di-N,N--(C.sub.1 -C.sub.5)alkylcarbamoyl, hydroxy(C.sub.1 -C.sub.5)alkyl, amino(C.sub.1 -C.sub.4)alkyl, mono-N-- or di-N,N--(C.sub.1 -C.sub.4)alkylamino(C.sub.1 -C.sub.4)alkyl, oxo, hydroxyimino or (C.sub.1 -C.sub.6)alkoxyimino with the proviso that only the R.sub.12 heterocycles thiazolidin-3-yl, pyrrolidin-1-yl, piperidin-1-yl, azetidin-1-yl, 1,2-oxazinan-2-yl, isoxazolidin-2-yl, or oxazolidin-3-yl are optionally mono- or di-substituted independently with oxo, hydroxyimino, or (C.sub.1 -C.sub.6)alkoxyimino; andwherein said R.sub.12 rings are optionally additionally mono- or di-substituted independently with (C.sub.1 -C.sub.5)alkyl andwith the proviso that R.sub.12 is not 2-carboxy-4-hydroxy-pyrrolidin-1-yl, 2-((C.sub.1 -C.sub.5)alkoxycarbonyl)-4-hydroxy-pyrrolidin-1-yl, 2-carboxy-piperidin-1-yl or 2-((C.sub.1 -C.sub.5)alkoxycarbonyl)-piperidin-1-yl.