Patent ID: 8952158
Filing Date: 2015-02-10
Classification: A61K,A61P,C07D

Abstract:
1. A method of preparing a compound represented by formula (I-B-1-2): wherein R R R a salt thereof, an N-oxide thereof, or a solvate thereof the process comprising: (1) condensing an amine compound of the following formula (A): with a carboxylic acid of the following formula (B): in the presence of 1-hydroxy-7-azabensotriazole (HOAt) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), to obtain a compound of the following formula (C): (2) subjecting the compound of formula (C) to a cyclization reaction in the presence of phosphorous oxychloride to obtain a compound of the following formula (D): (3) Reducing the compound of the formula (D) in the presence of sodium borohydride to obtain a compound of the following formula (II)′: (4) subjecting the compound of the formula (II)′ to an amidation reaction in the presence of pyridine and acetic anhydride.