Patent ID: 6653304
Filing Date: 2003-11-25
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula, or a pharmaceutically-acceptable salt or hydrate thereof, in which:R1 is (i) CHR17R18; or (ii) aryl, heterocyclo, or cycloalkyl optionally substituted with one to four groups selected from C1-6alkyl, C1-6alkoxy, hydroxy, halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, amino, C1-4alkylamino, aryl, cycloalkyl, and heterocyclo; R6 at each occurrence independent of each other R6 is selected from hydrogen, alkyl, substituted alkyl, heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, cycloalkyl, heterocyclo, hydroxy, alkoxy, amino, aminoalkyl, cyano, halogen, alkylamide, nitro, NR8C(&boxH;O)R9, S(O)uR10, â€”C(&boxH;O)R8, â€”CO2R8, â€”S(O)2NR8R9, â€”C(&boxH;O)N(R8)O(R9), â€”C(&boxH;O)NR8R9, and â€”OC(&boxH;O)R10; R6a is selected from hydrogen, alkyl, substituted alkyl, heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, cycloalkyl, heterocyclo, hydroxy, alkoxy, cyano, halogen, alkylamide, nitro, NR8C(&boxH;O)R9, S(O)uR10, â€”C(&boxH;O)R8, â€”CO2R8, â€”S(O)2NR8R9, â€”C(&boxH;O)N(R8)O(R9), â€”C(&boxH;O)NR8R9, and â€”OC(&boxH;O)R10; R8 and R9 at each occurrence are independently selected from hydrogen, alkyl, substituted alkyl, heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, and heterocyclo; or R8 and R9 together form a three-to-eight membered heterocyclo; R10 at each occurrence independent of each other R10 is selected from alkyl, substituted alkyl, heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl; R15 is at each occurrence selected from hydrogen, C1-4alkyl, hydroxy, halogen, cyano, C1-4alkoxy, trifluoromethyl, trifluoromethoxy, amino, NH(CH3), NH(Et), N(CH3)2, and C1-2alkyl substituted with amino, hydroxy, cyano, halogen, trifluoromethyl, and/or trifluoromethoxy; R17 and R18 are (CR21R22)sâ€”W; W at each occurrence is selected from hydrogen, alkyl, alkylamide, aminoalkyl, alkylthio, alkoxy, hydroxy, cyano, â€”CO2R19, â€”C(&boxH;O)R19, â€”C(&boxH;O)N(R19)O(R20), â€”NR19(C&boxH;O)R20, aryl, cycloalkyl, and heterocyclo; R19 and R20 are selected from hydrogen, alkyl, substituted alkyl, heterocycloalkyl, alkenyl, substituted alkenyl, cycloalkyl, aryl, and heterocyclo; R21 and R22 are independently hydrogen, alkyl, hydroxy, or hydroxyalkyl; Z is optionally-substituted heterocyclo; h is 2 or 3; j is 2 when the bond linking C3 and C4 is a double bond and j is 4 when said bond is a single bond; n is 1, 2, 3, or 4; s is 0, 1, 2, 3 or 4; and u is 0, 1, 2 or 3.