Patent ID: 6290973
Filing Date: 2001-09-18
Classification: A61K,A61P,C07F

Abstract:
A compound of the formula I ##STR310##wherein:R.sup.1 is selected from the group consisting of(a) C(O);(b) C(O)--C.sub.1-14 alkyl-C(O), wherein said C.sub.1-14 alkyl is optionally substituted with hydroxy, C.sub.1-5 alkoxy, C.sub.1-5 alkylenedioxy, C.sub.1-5 alkylamino, or C.sub.1-5 -alkyl-aryl, wherein said aryl moiety of said C.sub.1-5 -alkyl-aryl is optionally substituted with C.sub.1-5 alkoxy, C.sub.1-5 alkylamino, C.sub.1-5 alkoxy-amino, C.sub.1-5 alkylamino-C.sub.1-5 alkoxy, --O--C.sub.1-5 alkylamino-C.sub.1-5 alkoxy, --O--C.sub.1-5 alkylamino-C(O)--C.sub.1-5 alkyl C(O)OH, --O--C.sub.1-5 alkylamino-C(O)--C.sub.1-5 alkyl-C(O)--C.sub.1-5 alkyl;(c) C.sub.2 to C.sub.15 straight or branched chain alkyl optionally substituted with hydroxy or alkoxy; and(d) --C(O)--C.sub.6-12 arylene-C(O)-- wherein said arylene is optionally substituted with hydroxy, halogen, nitro or amino;a and b are independently 0, 1, 2, 3 or 4;d, d', d"", e, e' and e"" are independently an integer from 1 to 4;X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are independently selected from the group consisting of a null, oxygen, NH and N(C(O)C.sub.4 alkyl), and N(C.sub.1-4 alkyl).sub.2 ;W.sup.1 and W.sup.2 are independently selected from the group consisting of carbonyl, methylene, sulfone and sulfoxide;R.sup.2 and R.sup.5 are independently selected from the group consisting of:(a) C.sub.2 to C.sub.20 straight chain or branched chain alkyl which is optionally substituted with oxo, hydroxy or alkoxy,(b) C.sub.2 to C.sub.20 straight chain or branched chain alkenyl or dialkenyl which is optionally substituted with oxo, hydroxy or alkoxy;(c) C.sub.2 to C.sub.20 straight chain or branched chain alkoxy which is optionally substituted with oxo, hydroxy or alkoxy;(d) --NH--C.sub.2 to C.sub.20 straight chain or branched chain alkyl, wherein said alkyl group is optionally substituted with oxo, hydroxy or alkoxy; and(e) ##STR311##wherein Z is selected from the group consisting of O and NH, and M and N are independently selected from the group consisting of C.sub.2 to C.sub.20 straight chain or branched chain alkyl, alkenyl, alkoxy, acyloxy, alkylamino, and acylamino;R.sup.3 and R.sup.6 are independently selected from the group consisting of C.sub.2 to C.sub.20 straight chain or branched chain alkyl or alkenyl optionally substituted with oxo or fluoro;R.sup.4 and R.sup.7 are independently selected from the group consisting of C(O)C.sub.2 to C.sub.20 straight chain or branched chain alkyl or alkenyl; C.sub.2 to C.sub.20 straight chain or branched chain alkyl; C.sub.2 to C.sub.20 straight chain or branched chain alkoxy; C.sub.2 to C.sub.20 straight chain or branched chain alkenyl; wherein said alkyl, alkenyl or alkoxy groups can be independently and optionally substituted with hydroxy, fluoro or C.sub.1 to C.sub.5 alkoxy;G.sup.1, G.sup.2, G.sup.3 and G.sup.4 are independently selected from the group consisting of oxygen, methylene, amino, thiol, --NHC(O)--, and --N(C(O)C.sub.1-4 alkyl)--;or G.sup.2 R.sup.4 or G.sup.4 R.sup.7 may together be a hydrogen atom or hydroxyl;or a pharmaceutically acceptable salt thereof;with the proviso that the compound is not ##STR312##