Patent ID: 7306903
Filing Date: 2007-12-11
Classification: A61K,A61P,C07K

Abstract:
1. A method for identifying a compound that induces a morphogen-mediated biological effect, the morphogen selected from OP-1, OP-2, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, Vgl, Vgr-1, DPP, or 60A, the method comprising: (a) providing a test cell comprising a DNA comprising: wherein the reporter gene is transcribed when the DNA is present in a cell that is (b) exposing said test cell to a candidate compound; and (c) detecting expression of said detectable gene product, wherein an increase in expression of said detectable gene product after exposing said test cell to said candidate compound indicates the ability of the compound to induce the morphogen-mediated biological effect; wherein said morphogen-mediated biological effect requires the presence of said transcription activating element, so as to thereby identify a compound that induces a biological effect mediated by a morphogen.