Patent ID: 8993265
Filing Date: 2015-03-31
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide comprising a fibronectin type III tenth ( 10 Fn3) domain which binds to myostatin and comprises the amino acid sequence of SEQ ID NO: 6, wherein (Z) z , (Z) y and (Z) z comprise: (a) the amino acid sequences of SEQ ID NOs: 7, 39 and 46, respectively; (b) the amino acid sequences of SEQ ID NOs: 8, 40 and 47, respectively; (c) the amino acid sequences of SEQ ID NOs: 12, 42 and 51, respectively; (d) the amino acid sequences of SEQ ID NOs: 17, 39 and 56, respectively; (e) the amino acid sequences of SEQ ID NOs: 18, 39 and 57, respectively; (f) the amino acid sequences of SEQ ID NOs: 17, 39 and 62, respectively; (g) the amino acid sequences of SEQ ID NOs: 32, 44 and 73, respectively; (h) the amino acid sequences of SEQ ID NOs: 33, 45 and 74, respectively; (i) the amino acid sequences of SEQ ID NOs: 34, 39, and 75, respectively: (j) the amino acid sequences of SEQ ID NOs: 35, 39 and 75, respectively; or (k) the amino acid sequences of SEQ ID NOs: 38, 39 and 79, respectively.