Patent ID: 8741263
Filing Date: 2014-06-03
Classification: A61K

Abstract:
1. A method for determining the metabolic rate of a test molecule in an animal, the method comprising the steps of: a) administering a first molecule and a second molecule to the animal, wherein the second molecule is cleared from the animal at a rate lower than the rate at which the first molecule is cleared from the animal; b) determining the molecular ratio (R wherein I c) determining the rate constant of kidney clearance of the first molecule (k wherein c is a constant, a is a pre-exponential factor, and t is time; d) administering the test molecule for determination of the metabolic rate and the second molecule to the animal and determining the molecular ratio of the test molecule to the second molecule (R e) performing a least square fitting of the time series of molecular ratios of the test molecule to the second molecule ((R wherein c is a constant, k