Patent ID: 6995245
Filing Date: 2006-02-07
Classification: A61K,A61P,B82Y

Abstract:
1. An erythropoietic conjugate having the biological properties of causing bone marrow cells to increase production of reticulocytes and red blood cells, comprising a moiety of the formula: where EPO is erythropoietin or its pharmaceutical acceptable derivatives having biological properties of causing bone marrow cells to increase production of reticulocytes and red blood cells; Gln is a glutamine residue selected from one or more glutamine residues within the primary sequence of EPO; y is an integer from 1 to 7 indicating the number of modified glutamine residues; A is an amine donor moiety, wherein the linkage between the glutamine residue and the amine donor moiety is of the formula —CH 2 —CO—NH— where the gamma carboxamide group of the peptide bound glutamine residue is the acyl donor and the —NH-moiety is from the amine donor; X is an optional hydrophilic polymer moiety; M is an optional organic molecule characterized in that it is capable of increasing the circulating half-life of the EPO molecule; and n is an integer from 0 to 15, and the pharmaceutically acceptable salts or esters thereof.