Patent ID: 7829090
Filing Date: 2010-11-09
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An isolated specific binding member for IL-13, comprising, an antibody antigen-binding site which is composed of a human antibody VH domain and a human antibody VL domain and which comprises a set of CDRs HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, LCDR3, wherein the VH domain comprises HCDR1, HCDR2 and HCDR3 and the VL domain comprises LCDR1, LCDR2 and LCDR3, wherein the set of CDRs consists of a set of CDRs selected from the group consisting of: the BAK278D6 set of CDRs, defined wherein the HCDR1 has the amino acid sequence of SEQ ID NO:1, the HCDR2 has the amino acid sequence of SEQ ID NO:2, the HCDR3 has the amino acid sequence of SEQ ID NO:3, the LCDR1 has the amino acid sequence of SEQ ID NO:4, the LCDR2 has the amino acid sequence of SEQ ID NO:5, the LCDR3 has the amino acid sequence of SEQ ID NO:6, a set of CDRs which contains one amino acid substitution compared with the BAK278D6 set of CDRs wherein the one substitution is at one of the following residues within the CDRs, using the standard numbering of Kabat: 31, 32, 34 in HCDR1 52, 52A, 53, 54, 56, 58, 60, 61, 62, 64, 65 in HCDR2 96, 97, 98, 99, 101 in HCDR3 26, 27, 28, 30, 31 in LCDR1 56 in LCDR2 95A, 97 in LCDR3, and the set of CDRs present within any of the individual isolated IL-13 specific binding members listed in Table 1.