Patent ID: 8512947
Filing Date: 2013-08-20
Classification: C12Q,G01N

Abstract:
1. A method comprising: immobilizing a probe material to a non-piezoelectric layer surface of a sensor, wherein the probe material is bindable to a target nucleic acid, the sensor comprising: measuring, via the electrodes, a first resonance frequency of the sensor; exposing the sensor surface, having the probe material immobilized thereon, to the target nucleic acid; measuring, via the electrodes, a second resonance frequency of the sensor, wherein the first resonance frequency is measured prior to the exposing and the second resonance frequency is measured subsequent to the exposing; determining, via a comparison of the first resonance frequency and the second resonance frequency, an amount of total mass sensed by the sensor via the exposure; and determining a portion of the total mass attributable to the target nucleic acid.