Patent ID: 7459172
Filing Date: 2008-12-02
Classification: A61K,B82Y,C07K

Abstract:
1. A method of producing a polypeptide polymer comprising the steps of: (a) providing a plurality of monomeric polypeptides and at least one divalent cation or at least one template molecule, wherein the monomer polypeptides are capable of self assembly in the presence of a divalent cation or at least one template molecule; and (b) (i) polymerizing the monomeric polypeptides through a self assembly process in the presence of the at least one divalent cation, or, (ii) polymerizing the monomeric polypeptides in the presence of the at least one template molecule, under conditions wherein the monomeric polypeptides self assemble, thereby producing a polypeptide polymer, wherein each monomeric polypeptide of the plurality of monomeric polypeptides have either (a) an amino acid sequence as set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, or SEQ ID NO:10, or, (b) an amino acid sequence as set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, or SEQ ID NO:10, and having at least one conservative substitution, and at least one monomeric polypeptide of the plurality of monomeric polypeptides includes a modification comprising attachment of a polypeptide.