Patent ID: 9109021
Filing Date: 2015-08-18
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising: an antibody or fragment thereof that specifically binds to an N-terminal epitope of pyro-Glu-(3-40/42)-Aβ that includes SEQ ID NO: 3; wherein the antibody or binding fragment thereof comprises at least one of (i) a heavy chain variable domain that includes the amino acid sequences of the three CDRs in SEQ ID NO: 13 and a light chain variable domain that includes the amino acid sequences of the three CDRs in SEQ ID NO: 14, (ii) a heavy chain variable domain that comprises SEQ ID NO: 13, (iii) a light chain variable domain that comprises SEQ ID NO: 14, or (iv) a heavy chain variable domain that comprises SEQ ID NO: 13 and a light chain variable domain that comprises SEQ ID NO: 14.