Patent ID: 8188071
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. A compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein: B is pyridyl, wherein B is optionally and independently substituted with R Z is O; R T1 is absent or C1-10 aliphatic, wherein up to three methylene units of T1 are optionally and independently replaced by G wherein G is —O—, —S—, —S(O)—, —S(O) Q1 is absent, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Q1 is optionally and independently substituted with J1 and independently optionally and independently substituted with one or more R J11 is —Y1-M1; Y1 is absent, oxo, or C1-10 aliphatic wherein up to three methylene units of Y1 are optionally and independently replaced with G1 wherein G1 is —N(R M1 is C1-6 aliphatic, C3-8 cycloaliphatic, haloC1-4 aliphatic, —O(haloC1-4 aliphatic), 3-8 membered heterocyclyl, 5-6 membered heteroaryl, phenyl, —OR R R T2 is absent; Q2 is 1,4-diazepane ring, wherein Q2 is optionally and independently substituted with J2 and independently optionally and independently substituted with one or more R J2 is —Y2-M2; Y2 is absent, oxo, or C1-10 aliphatic, wherein up to three methylene units of Y2 are optionally and independently replaced with G1′ wherein G1′ is —N(O)—, —O—, —S—, —C(O)—, —S(O)—, or —S(O) M2 is C1-6 aliphatic, C3-8 cycloaliphatic, haloC1-4 aliphatic, —O(haloC1-4 aliphatic), 3-8 membered heterocyclyl, heteroaryl, aryl, —OR each J is independently halogen, C1-6 aliphatic, C3-6 cycloaliphatic, —NO R each JT1 is independently halogen, —CN, —N(O) each JT2 is independently halogen, —CN, —N(O) each R each R each R each JT3 is independently halogen, —CN, —NO each JT4 is independently halogen, C1-C6 alkyl, or C1-C6 alkoxy; each R p is 0, 1 or 2.