Patent ID: 9205065
Filing Date: 2015-12-08
Classification: A61K,A61P,C12N

Abstract:
1. A method of treating herpes simplex virus (HSV) infection to reduce the frequency or severity of future HSV outbreaks in a person infected with HSV comprising: (a) locally administering at a site of an HSV lesion on a person in need of treatment for HSV infection to reduce the frequency or severity of future HSV outbreaks a substance that induces a delayed type hypersensitivity (DTH) response to induce a DTH response at the site of the lesion during one or more outbreaks of the HSV infection; wherein the substance that induces a DTH response is a topical contact sensitizer; wherein the method reduces the frequency or severity of subsequent HSV outbreaks in the person; wherein step (a) comprises topically applying the substance that induces a DTH response to a patient at a site of an HSV lesion to induce a DTH response at the site of the lesion; wherein the substance that induces a DTH response is squaric acid, a squaric acid ester, diphenylcyclopropenone (DPCP), 1-chloro-2,4-dinitrobenzene (DNCB), or 1-chloro-2,6-dinitrobenzene.