Patent ID: 8846315
Filing Date: 2014-09-30
Classification: A61K,A61P,C12Q

Abstract:
1. A method of determining increased risk for development of Alzheimer's disease in a human subject, comprising: (a) detecting the length of a poly-T deletion/insertion polymorphism (DIP) at rs10524523 in intron 6 of the TOMM40 gene from a biological sample containing deoxyribonucleic acid taken from said subject, wherein said poly-T DIP has a length of 19, 20, 21, 22, 23, 26, 27, 28, 29, or 30; (b) correlating the detected poly-T length of 19, 20, 21, 22, 23, 26, 27, 28, 29, or 30 at rs10524523 with an increased risk of development of Alzheimer's disease; and (c) administering an anti-Alzheimer's disease active agent to said subject in an amount effective for treating said subject.