Patent ID: 6602864
Filing Date: 2003-08-05
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I is isoquinoline;Z is alkylenyl; R1 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl, unsubstituted or substituted heteroaralkyl, R'O(CH2)xâ€”, R'O2C(CH2)xâ€”, Y1Y2NC(O)(CH2)xâ€”, or Y1Y2N(CH2)xâ€”; R' is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl or unsubstituted or substituted heteroaralkyl; R2 is R3S(O)pâ€” or R3R4NS(O)pâ€”; R3 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted aralkyl, unsubstituted or substituted heteroaralkyl, unsubstituted or substituted aralkenyl or unsubstituted or substituted heteroaralkenyl, or R1 and R3 taken together with the â€”Nâ€”S(O)pâ€” moiety or the â€”Nâ€”S(O)pâ€”NR4â€” moiety through which R1 and R3 are linked form a 5 to 7 membered unsubstituted or substituted heterocyclyl; and R4 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted aralkyl or unsubstituted or substituted heteroaralkyl, or R3 and R4 taken together with the nitrogen to which R3 and R4 are attached form an unsubstituted or substituted 4 to 7 membered heterocyclyl; X1 and X1a are independently selected from H, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aralkyl, unsubstituted or substituted heteroaryl or unsubstituted or substituted heteroaralkyl, or X1 and X1a taken together form oxo; X2 and X2a are H, or taken together form oxo; X3 is H, hydroxy, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted aralkyl or unsubstituted or substituted heteroaralkyl, or X3 and one of X1 and X1a taken together form a 4 to 7 membered cycloalkyl; X4 is H, unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl, or hydroxyalkyl; X5, X5a and X5b are independently selected from H, R5H6Nâ€”, (hydroxy, alkoxy or amino)HNâ€”, R7Oâ€”, R5R6NCOâ€”, R5R6NSO2â€”, R7COâ€”, halo, cyano, nitro or R8(O)C(CH2)qâ€”, and one of X5, X5a and X5b is H, hydroxy or (H, unsubstituted or substituted lower alkyl, hydroxy, alkoxy or amino)HNâ€” that substitutes said isoquinoline ring at a position alpha to the nitrogen; Y1 and Y2 are independently hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aralkyl or unsubstituted or substituted heteroaralkyl, or Y1 and Y2 taken together with the N through which Y1 and Y2 are linked form a 4 to 7 membered heterocyclyl; R5 and R6 are independently H or unsubstituted or substituted lower alkyl, or one of R5 and R6 is H and the other of R5 and R6 is R8(O)CCH2â€” or lower acyl; R7 is H, unsubstituted or substituted lower alkyl, lower acyl or R8(O)CCH2â€”; R8 is H, unsubstituted or substituted lower alkyl, alkoxy or hydroxy; m is 0, 1, 2 or 3; p is 1 or 2; q is 0 or 1, and x is 1, 2, 3, 4, or 5, or a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.