Patent ID: 9034343
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant, infectious, self-replicating human parainfluenza virus 2 (HPIV2) comprising a partial or complete polyhexameric genome or antigenome comprising a variant polynucleotide having: a monocistronic polynucleotide with an open reading frame (ORF) encoding a P protein, which does not encode a V protein, and a monocistronic polynucleotide with an open reading frame (ORF) encoding a V protein, wherein the two monocistronic polynucleotides are separated by a non-coding polynucleotide spacer sequence comprising a gene end transcription signal, intergenic transcription signal, and gene start transcription signal, wherein said P protein and said V protein are encoded by separate polynucleotides.