Patent ID: 8389560
Filing Date: 2013-03-05
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A compound of formula (I): wherein R R A is N or CH; U is —O—, —NH—, —NH(CO)—, —NHSO—, or —NHSO W is —(CH X is —O—, —S—, or —NH; Y is in which each of V and T, independently, is —CH— or —N—; each of A 1 and A 2 , independently, is a moiety selected from C 4-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of which is optionally mono-, di-, or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl, or optionally fused with C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl; and R i is H, halo, nitro, cyano, or amino, or is a moiety selected from C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, and C 2-6 alkynyl being optionally mono-, di- or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl, and each of C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl being optionally mono-, di- or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl, or optionally fused with C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl; and