Patent ID: 6740657
Filing Date: 2004-05-25
Classification: A61P,C07D

Abstract:
A compound of Formula (I): wherein:R1 is selected from the group consisting of aryl, heteroaryl and C3-C8 cycloalkyl optionally substituted with one to five substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy, aryl, heteroaryl, amino, amido, amidino, guanidino, hydroxy, nitro and cyano; R2 and R3 are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl and aryl(C1-C8)alkyl; alternatively, when independently selected from the group consisting of C1-C8 alkyl and C2-C8 alkenyl, R2 and R3 may, together with the nitrogen to which they are attached, form a saturated or partially saturated 4 to 6 membered heterocyclyl ring; n is an integer selected from 0, 1, 2 or 3; X is selected from the group consisting of hydrogen, â€”OR4, â€”NH2, â€”NHR4 and â€”NR4R5; R4 and R5 are independently selected from the group consisting of C1-C8alkyl, C3-C8 cycloalkyl and aryl(C1-C8)alkyl; Y is selected from the group consisting of halogen, â€”NH2, â€”NHR6, â€”NR6R7, â€”A1â€”NH2, â€”A1â€”NHR6, â€”A1â€”NR6R7, â€”A1â€”A2â€”NH2, â€”A1â€”A2â€”NHR6 and â€”A1â€”A2â€”NR6R7; R6 and R7 are independently selected from the group consisting of C1-C8alkyl, C3-C8 cycloalkyl and aryl(C1-C8)alkyl; and, A1 and A2 are independently selected from the L-amino acid residue group consisting of arginine, homoarginine, 2,4-diaminobutyric acid, lysine, ornithine, histidine, phenylalanine, homophenylalanine, naphthylalanine, cyclohexylalanine, tryptophan and tyrosine optionally substituted with one to three substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy, aryl, heterocyclyl, amino, amido, amidino, guanidino, hydroxy, nitro and cyano; and pharmaceutically acceptable salts thereof.