Patent ID: 9115357
Filing Date: 2015-08-25
Classification: A61K,A61P,C12N

Abstract:
1. A composition comprising microspheres, said microspheres comprising (a) polyvinyl pyrrolidone and polyethylene glycol, (b) a polycation, and (c) thiolated oligonucleotides including a first antisense sequence that targets CD40 primary transcript, a second antisense sequence that targets CD80 primary transcript, and a third antisense sequence that targets CD86 primary transcript, wherein each of said first, second and third oligonucleotides reduces or suppresses in vivo expression of CD40, CD80 and CD86, respectively, and wherein said oligonucleotides comprise greater than about 30 weight percent of the microspheres, based on total weight of the microspheres, said microspheres having an average particle size of at least 0.2 microns and not greater than about 50 microns, and said microspheres, when administered, treat type 1 diabetes.