Patent ID: 8911723
Filing Date: 2014-12-16
Classification: A61K,C12N

Abstract:
1. A hybrid hydrogel scaffold, the scaffold comprising: (a) about 0.75% to about 1.25% EFK8 (w/v); (b) about 20% poloxamer 407 (w/v); wherein the scaffold provides a microenvironment that: (i) substantially prevents the aggregation of cells, (ii) promotes cell proliferation at a rate that is improved or substantially similar to a hydrogel scaffold made from EFK8 alone, and (iii) has viscoelastic properties that are improved or substantially similar to a hydrogel scaffold made from poloxamer 407 alone; and (c) mesenchymal stem cells; wherein the mesenchymal stem cells are capable of differentiation when the scaffold is transplanted in vivo.