Patent ID: 6319514
Filing Date: 2001-11-20
Classification: A61K,A61P

Abstract:
A method for eliciting an onset hastened analgesic and anti-inflammatory response and combating nausea in acute migraine attacks in a subject in need of an analgesic, anti-inflammatory and anti-nausea response, comprising administering a pharmaceutical composition comprising effective amounts of more than one active ingredient to said subject, wherein said more than one active ingredient consist essentially of:(i) domperidone or an analogue thereof in an amount sufficient to hasten the onset of the analgesic and anti-inflammatory response and to combat nausea in an acute migraine attack,(ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (-) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenec, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam; and(iii) a narcotic analgesic, or a pharmaceutically acceptable salt thereof or a pure (-) or (+) pure optical isomer thereof in an analgesically effective amount.