Patent ID: 6194437
Filing Date: 2001-02-27
Classification: A61P,C07D

Abstract:
A compound of Formula I ##STR164##or a pharmaceutically acceptable salt thereof whereinAr is phenyl or pyridyl unsubstituted or substituted from 1 to 3 sustituents selected from alkyl, halogen, alkoxy, nitro, amino, NH.sub.2 CH.sub.2-, cyano, CF.sub.3, --NHCONH.sub.2, and CO.sub.2 R.sup.1 ;R.sup.1 is hydrogen or straight, branched, or cyclic alkyl of from 1 to 7 carbon atoms;R.sup.8 is hydrogen or forms a ring with R.sup.1 of from 3 to 7 carbon atoms;R.sup.2 is hydrogen or straight, branched, or cyclic alkyl of form 1 to 8 carbon atoms;R.sup.9 is hydrogen or forms a ring of from 3 to 7 carbon atoms with R.sup.2 ;Ar.sup.1 can be independently selected from Ar and can also include pyridyl-N-oxide, indolyl, pyridyl, and imidazole;R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are each independently selected from hydrogen and methyl;R.sup.3 can be independently selected from Ar or is hydrogen, hydroxy, NMe.sub.2, N-methyl-pyrrole, ##STR165##wherein Ar.sup.2 is phenyl or pyridyl with the proviso that when Ar.sup.1 is phenyl, said phenyl is substituted; --[CR.sup.1 (R.sup.8)].sub.0-1 --(CH.sub.2).sub.0-1 -- is not --(CH.sub.2).sub.1-2 ; and --(CH.sub.2).sub.0.3 --[CR.sup.2 (R.sup.9)].sub.0-1 --(CH.sub.1).sub.0-2 -- is not --(CH.sub.2).sub.1-6 --.