Patent ID: 6031111
Filing Date: 2000-02-29
Classification: A61P,C07D

Abstract:
A compound represented by formula (II): ##STR209## wherein R.sub.1 represents a halogen atom; a lower alkyl group; a lower alkoxy group; a hydroxyl group; a nitro group; a trifluoromethyl group; a lower alkylthio group; a carbonyl group which is substituted by a hydrogen atom, lower alkyl, a carbocylic aryl group having 6-14 carbon atoms, lower alkoxy group or an amino group; a carboxyl group; a mercapto group or a substituted or unsubstituted amino group;R.sub.3 represents a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms; a substituted or unsubstituted cycloalkyl group having 3-8 carbon atoms; a substituted or unsubstituted aryl group having 6-14 carbon atoms;n represents an integer of from 0 to 4; andR.sub.9 represents a group represented by formula (III): ##STR210## wherein R.sub.10 and R.sub.11 each represent a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms, or a group represented by formula (IV): ##STR211## wherein Z represents a substituted or unsubstituted lower alkylene group having 1-8 carbon atoms, or a salt thereof or an optically active isomer thereof, wherein the substituents in the definition of R.sub.1, R.sub.3, R.sub.10, R.sub.11 and Z represent a halogen atom; a lower alkyl group having 1-6 carbon atoms; a C3-C8 cycloalkyl group; a C6-C14 aryl group; a hydroxyl group; a lower alkoxy group having 1-6 carbon atoms; a C6-C14 aryloxy group; a lower alkylthio group; --CH(OR').sub.2, wherein R' represents a lower alkyl group having 1-6 carbon atoms; a lower alkylcarbonyl group; a C6-C14 arylcarbonyl group; a carboxyl group; a lower alkoxycarbonyl group; an amino group which may be substituted with one to two methyl groups, an ethyl group or a trifluoromethylcarbonyl group; an imino group; --CR""(SR').sub.2, wherein R' and R"" represent a lower alkyl group having 1-6 carbon atoms; a nitro group; a nitrile group; or a trifluoromethyl group.