Patent ID: 9125941
Filing Date: 2015-09-08
Classification: A61K,B82Y,C01G,C01P

Abstract:
1. An aqueous method of making polymer coated superparamagnetic nanoparticles, the method comprising: providing a mixture of iron salts in aqueous hydrochloric acid; combining a solution of ammonium hydroxide with the mixture and stirring for a time sufficient for formation of a suspension of iron oxide nanoparticles; adding to the suspension one or more aqueous biocompatible polymers thereby coating the nanoparticles with polymer, wherein optionally at least one of the polymers is aminated; centrifuging the suspension, rendering a supernatant without large particles; filtering the supernatant through an ultrafiltration membrane and collecting the filtrate containing the polymer coated nanoparticles; crosslinking the polymer coating by treating the nanoparticles with epichlorohydrin and sodium hydroxide while mixing for up to about eight hours; aminating any un-aminated crosslinked polymer remaining by treating with ammonia; and removing free epichlorohydrin from the suspension.