Patent ID: 8394814
Filing Date: 2013-03-12
Classification: A61P,C07D

Abstract:
1. A method for separating noscapine from an opium source comprising at least one impurity that undergoes an irreversible color change when exposed to a pH of less than about 5, the method comprising: (a) contacting the opium source with a first solvent that substantially causes the dissolution of noscapine to form a reaction mixture comprising a pH of greater than about 5; and, (b) contacting the reaction mixture with a second solvent that reduces the solubility of the noscapine in the reaction mixture without substantially changing the solubility of the impurity such that the noscapine recrystallizes thereby separating the noscapine from the impurity in a manner that does not cause an irreversible color change in the impurity.