Patent ID: 6479265
Filing Date: 2002-11-12
Classification: A61K,A61P,C07F,C07K,C12N

Abstract:
A catalytic antibody which enhances the rate of hydrolysis of an unactivated primary amide bond, wherein the antibody is produced by a method comprising the steps of:(i) immunizing an animal with a composition comprising a hapten comprising a compound of the formula: R1â€”Yâ€”NHâ€”CHâ€”(R2)â€”X wherein R1 is H or branched or a linear, substituted or unsubstituted C1-21 alkyl, alkene or alkyne, Y is a polypeptide, R2 is an amino acid side chain, and X is selected from the group consisting of â€”P(O)(CH3)(OH), â€”P(O)(OH)(OCH3), and â€”C(O)(CF3);(ii) removing antibody-producing lymphocytes from said animal; and (iii) fusing the lymphocytes with myeloma cells and thereby producing hybridoma cells producing the antibody.