Patent ID: 8658379
Filing Date: 2014-02-25
Classification: C07K,G01N

Abstract:
1. A method of diagnosing sepsis in a subject, comprising (i) determining the level of follistatin-like protein-1 in a serum sample from a subject manifesting one or more of: an identified locus of infection, fever or a body temperature lower than normal; tachycardia; tachypnea; an elevated white blood cell count or neutropenia and/or greater than 10% immature band forms; (ii) comparing the level of follistatin-like protein-1 in the serum sample to a control level of follistatin-like protein-1 as determined by measuring the follistatin-like protein-1 level in serum from one or more healthy subjects, and (iii) diagnosing sepsis where a serum level of follistatin-like protein-1 in the sample of the subject is at least 50% higher than the control level of follistatin-like protein-1 indicates that the subject has sepsis.