Patent ID: 8518880
Filing Date: 2013-08-27
Classification: A61K,A61P

Abstract:
1. A method of improving motor function in a human or an animal having a spinal cord injury comprising: selecting a subject who/which is a human or an animal having a spinal cord injury; and providing said human or animal with a hepatocyte growth factor (HGF) preparation of which active ingredient is an HGF protein by intrathecal administration to improve motor function in the human or animal having a spinal cord injury, the HGF being selected from the group consisting of (a) HGF having the amino acid sequence of SEQ ID NO:1, (b) HGF having the amino acid sequence of SEQ ID NO:2, (c) HGF having an amino acid sequence with at least 95% identity with the amino acid sequence of SEQ ID NO:1 and possessing HGF activity, (d) HGF having an amino acid sequence with at least 95% identity with the amino acid sequence of SEQ ID NO:2 and possessing HGF activity, (e) HGF produced by a method that comprises integrating a gene encoding the amino acid sequence of SEQ ID NO:1 into a vector; transforming a host cell with the vector; expressing a recombinant HGF from the vector; and obtaining a recombinant HGF from a culture supernatant of the transformant, and (f) HGF produced by a method that comprises integrating a gene encoding the amino acid sequence of SEQ ID NO:2 into a vector; transforming a host cell with the vector; expressing a recombinant HGF from the vector; and obtaining a recombinant HGF from a culture supernatant of the transformant.