Patent ID: 7528093
Filing Date: 2009-05-05
Classification: A61P,C12Q

Abstract:
1. A method for selecting a compound that modulates an activity of an SCN3A sodium channel comprising: (a) contacting a composition comprising said SCN3A sodium ion channel protein having the amino acid sequence as set forth in SEQ ID NO:67, wherein the asparagine residue at amino acid position 43 is deleted or the valine residue at amino acid position 1035 is an isoleucine, with at least one test compound; (b) assaying the activity of the sodium ion channel in the presence of the at least one test compound; (c) comparing the activity of the sodium ion channel in the absence of the at least one test compound; (d) selecting a compound that modulates the activity of the sodium ion channel as compared to the activity in the absence of the at least one test compound.