Patent ID: 8673918
Filing Date: 2014-03-18
Classification: A61K,A61P

Abstract:
1. A stable pharmaceutical composition for oral administration comprising: (i) a compound selected from 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol in free form, a pharmaceutically acceptable salt thereof, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol-phosphate, 1-{4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid, and (ii) one or more of the following excipients: (a) one or more Fillers selected from the group consisting of Lactose monohydrate, Lactose anhydrous, Maize starch, sucrose, and Microcrystalline cellulose, citric acid and sodium hydrogen carbonate; (b) one or more Binders selected from the group consisting of HPMC, and HPC; (c) one or more Disintegrants selected from the group consisting of Maize starch, Croscarmellose sodium, Sodium carboxymethylstarch, and pregelatinized; (d) one or more Lubricants selected from the group consisting of Hydrogenated castor oil and magnesium stearate; (e) a Flow regulator that is Colloidal silicone dioxide; (f) one or more Matrix formers selected from the group consisting of Hydroxypropyl methyl cellulose, Hydroxypropyl cellulose, Starch and Povidone.