Patent ID: 6187285
Filing Date: 2001-02-13
Classification: A61K,C07D,Y10S

Abstract:
Chelate of a cation of a paramagnetic metal with a compound of formula ##STR42##in whichm is 1 or 2,R' is selected from the group consisting of H, a C.sub.1 -C.sub.4 alkyl or hydroxyalkyl group, a group CH.sub.2 --COOH and a group CH.sub.2 --CONZ.sub.1 Z.sub.2, Z.sub.1 and Z.sub.2 being, independently of each other, H or an optionally hydroxylated C.sub.1 -C.sub.4 alkyl group,or R' is a group ##STR43##R is a group ##STR44##in which a is 1 or 2Z is selected from the group consisting of a bond, CH.sub.2,CH.sub.2 CONH and (CH.sub.2).sub.2 NHCOZ' is selected from the group consisting of a bond, O, S, NQ, CH.sub.2, CO, CO--NQ, NQ--CO, NQ--CO--NQ and CO--NQ--CH.sub.2 --CONQZ"" is selected from the group consisting of CO--NQ, NQ--CO, CO--NQ--CH.sub.2 --CO--NQ and NQ--CO--CH.sub.2 --NQ--COwhere Q is H or an optionally hydroxylated C.sub.1 -C.sub.4 alkyl groupR.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of each other, are selected from the group consisting of H, Br, Cl, I, CO--NQ.sub.1 Q.sub.2 and N(Q.sub.1)--CO--Q.sub.2 and Q.sub.1 and Q.sub.2 are independently selected from C.sub.2 -C.sub.6 alkyl groups which are optionally interrupted by an oxygen atom, wherein at least one of Q.sub.1, Q.sub.2 is hydroxylated such that Q.sub.1 and Q.sub.2 together contain from 4 to 10 OH groups,with the proviso that at least 1, and not more than 2, groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are amido groups,and the salts thereof with a pharmacologically acceptable organic base or inorganic base.