Patent ID: 9018251
Filing Date: 2015-04-28
Classification: A61K,A61P

Abstract:
1. A method for treating a glioma in a subject, comprising: administering to the subject (1) an effective amount of the (Z)-butylidenephthalide isomer of formula (I) substantially free from the (E)-butylidenephthalide isomer of formula (I), wherein the (Z)-butylidenephthalide isomer of formula (I) is in the form of the (Z)-butylidenephthalide isomer, a pharmaceutically acceptable salt of the (Z)-butylidenephthalide isomer, a pharmaceutically acceptable ester of the (Z)-butylidenephthalide isomer, or a combination thereof: and (2) an effective amount of temozolomide, wherein (1) and (2) together provide a combination index less than 1.