Patent ID: 6756376
Filing Date: 2004-06-29
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I); wherein E is N or Câ€”R4; when E is N, G is Câ€”R25, or when E is Câ€”R4, G is N; R1 is a group selected from (a) C1 to C20 alkyl, C1 to C20 alkenyl, C1 to C20 alkynyl, carbocyclic groups, and heterocyclic groups, and (b) the groups represented by (a) each substituted independently with at least one group selected from non-interfering substituents, or (c) â€”(L1)â€”R5, wherein L1 is a divalent linking group of 1 to 18 atom(s) selected from hydrogen atom(s), nitrogen atom(s), carbon atom(s), oxygen atom(s), and sulfur atom(s), and R5 is a group selected from the groups (a) and (b); one of R3 and R4 is â€”(L2)-(acidic group), wherein L2 is an acid linker having an acid linker length of 1 to 5 and the other is a hydrogen atom, and the acidic group is represented by the formula: wherein R16 is a hydrogen atom, a metal, or C1 to C10 alkyl; each R17 is independently a hydrogen atom or C1 to C10 alkyl; h is an Integer from 1 to 8; wherein A ring is a group represented by the formula: wherein R2 is CONH2, CONHNH2 or CSNH2; R18, R19, R20, R21, R22, R23, R26, and R27 are each independently a hydrogen atom, or lower alkyl; R24 and R25 are each independently a hydrogen atom, C1 to C6 alkyl, aryl, a halogen or aralkyl; its C1-C8 alkyl, acyloxyalkyl, and alkyloxycarbonyloxyalkyl ester, its pharmaceutically acceptable salt, or hydrate thereof.