Patent ID: 7459462
Filing Date: 2008-12-02
Classification: A61P,C07D

Abstract:
1. A compound according to the general formula Ia or Ib: wherein in each, R1 is H, C R2 is C —CH═N—NHSO 2 aryl, or —CH═N—NHSO wherein m is 1 to 6, o is 1, p is 1 to 2m+o; m is 2 to 6, o is −1, p is 1 to 2m+o; or m is 4 to 6, o is −2, p is 1 to 2m+o; Y″ is independently from each other selected from the group consisting of halogen, OH, OR21, NH wherein X′ is NR215, O, or S; and R211, R212, R213, R214, R215 are independently from each other H or C R21, R22 are independently from each other C R23 independently of R21, is R21, a CH R24 independently of R21, is R21, H, CN, COCH R25 independently of R21, is R21, H, CN, COCH R24, R25 together are C R3 is C cycloalkyl, C (with X′ ═NR315, O, S, and R311, R312, R313, R314, R315 being independently from each other H or C 1 -C 6 alkyl), —CH═N—NHSO 2 aryl, or —CH═N—NHSO 2 -heteroaryl, wherein m is 2-6, o is 1 or −1, and p is 1 to 2m+o; or m is 4-6, o is −3 and p is 1 to 2m+o; and Y′ is independently from each other selected from the group consisting of halogen, OH, OR31, NH2, NHR31, NR31R32, SH, and SR31; and wherein n is 0, 1 or 2; R31, R32 mean independently from each other C R33 independently of R31, is R31, a CH R34 independently of R21, is R31, H, CN, COCH R35 independently of R31, is R31, H, CN, COCH R34, R35 together are C R5 is H, C R4, R6, R7 independently from each other are H, C R41 independently of R21, is R21; X is O, S, NH, or N—R8, wherein R8 independently from R5 is R5, or R5 and R8, together with the N, form a ring with 4, 5, 6, 7, or 8 members, which may optionally contain still another heteroatom selected from the group consisting of N, O, and S; or X—R5 may together be H; Y is O, S, or NR9, wherein R9 is H or C or a stereoisomer, tautomer or physically tolerable salt thereof.