Patent ID: 6121330
Filing Date: 2000-09-19
Classification: A61P,C07C

Abstract:
5-Hydroxy-alkyl-substituted phenyls of the general formula (I) ##STR30## in which A represents aryl having 6 to 10 carbon atoms which is optionally substituted up to 5 times by identical or different substituents from the group consisting of halogen, hydroxyl, trifluoromethyl, nitro, trifluoromethoxy, or by straight-chain or branched alkyl, acyl, hydroxyalkyl or alkoxy having in each case up to 7 carbon atoms, or by a group of the formula --NR.sup.3 R.sup.4 in whichR.sup.3 and R.sup.4 are identical or different and each represents hydrogen, phenyl, or straight-chain or branched alkyl having up to 6 carbon atoms,D represents aryl having 6 to 10 carbon atoms which is optionally substituted by nitro, halogen, trifluoromethyl or trifluoromethoxy, or represents a radical of the formula ##STR31## in which R.sup.5, R.sup.6 and R.sup.9 are identical or different and each represents cycloalkyl having 3 to 6 carbon atoms or aryl having 6 to 10 carbon atoms or forms a 5- to 7-membered, optionally benzo-fused, saturated or unsaturated, mono-, bi- or tricyclic heterocycle having up to 4 carbon atoms from the group consisting of S, N and O, where the cycles, in the case of the nitrogen-containing rings also via the N-function, are optionally substituted up to 5 times by identical or different substituents from the group consisting of halogen, trifluoromethyl, nitro, hydroxyl, cyano, carboxyl, trifluoromethoxy, straight-chain or branched acyl, alkyl, alkylthio, alkylalkoxy, alkoxy and alkoxycarbonyl having in each case up to 6 carbon atoms, by aryl having 6 to 10 carbon atoms or by an optionally benzo-fused aromatic 5- to 7-membered heterocycle having up to 3 heteroatoms from the group consisting of S, N and/or O, and/or by a group of the formula --OR.sup.10, --SR.sup.11, --SO.sub.2 R.sup.12 or --NR.sup.13 R.sup.14, in whichR.sup.10, R.sup.11 and R.sup.12 are identical or different and each represents aryl having 6 to 10 carbon atoms which for its part is substituted up to 2 times by identical or different substituents from the group consisting of phenyl, halogen or by straight-chain or branched alkyl having up to 4 carbon atoms,R.sup.13 and R.sup.14 are identical or different and have the meaning of R.sup.3 and R.sup.4 given above, orR.sup.5 or R.sup.6 each represent a radical of the formula ##STR32## T represents straight-chain or branched alkyl or alkenyl having in each case 2 to 10 carbon atoms which are optionally substituted up to 2 times by hydroxyl,R.sup.7 represents hydrogen or halogen, andR.sup.8 represents hydrogen, halogen, azido, trifluoromethyl, hydroxyl, trifluoromethoxy, straight-chain or branched alkoxy having up to 5 carbon atoms or a radical of the formula --NR.sup.15 R.sup.16, in whichR.sup.15 and R.sup.16 are identical or different and have the meaning of R.sup.3 and R.sup.4 given above, orR.sup.7 and R.sup.8 together form a radical of the formula .dbd.O or .dbd.NR.sup.17, in whichR.sup.17 is hydrogen or straight-chain or branched alkyl, alkoxy or acyl having in each case up to 6 carbon atoms,U and W are identical or different and each represents straight-chain or branched alkyl having up to 8 carbon atoms, orU or W represent a bond,V represents an oxygen or sulphur atom or represents a radical of the formula --NR.sup.18, in whichR.sup.18 represents hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms or phenyl,E represents cycloalkyl having 3 to 8 carbon atoms, or represents straight-chain or branched alkyl having up to 8 carbon atoms which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or hydroxyl, or represents phenyl which is optionally substituted by halogen or trifluoromethyl,L represents hydrogen, hydroxyl, straight-chain or branched alkoxy or alkyl having in each case up to 6 carbon atoms or represents a radical of the formula --NR.sup.19 R.sup.20 or ##STR33## in which R.sup.19 and R.sup.20 have the meanings of R.sup.3 and R.sup.4 given above and are identical to or different from these, anda represents a number 1, 2 or 3,R.sup.1 represents straight-chain or branched alkyl having up to 6 carbon atoms which is substituted by hydroxyl,R.sup.2 represents aryl having 6 to 10 carbon atoms which is optionally substituted by halogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, straight-chain or branched alkyl, alkoxy, acyl or alkoxycarbonyl having in each case up to 6 carbon atoms, hydroxyl, carboxyl or by a group of the formula --NR.sup.21 R.sup.22, in whichR.sup.21 and R.sup.22 are identical or different and have the meanings of R.sup.3 and R.sup.4 given above,and their salts.