Patent ID: 8546435
Filing Date: 2013-10-01
Classification: A61K,A61P,C07D

Abstract:
1. A triazole compound, selected from the group consisting of: compound 1 [5-{(R)-2-(1H-Indol-3-yl)-1-[(pyridine-3-carbonyl)-amino]-ethyl}-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-acetic acid ethyl ester; compound 2 N-[(R)-1-[5-Carbamoylmethyl-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-nicotinamide; compound 3 Pyridine-2-carboxylic acid [(R)-1-[5-[(R)-1-acetylamino-2-(1H-indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 4 Pyridine-2-carboxylic acid [(R)-1-[5-((R)-1-acetylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 5 Pyridine-2-carboxylic acid [(R)-1-[5-((R)-1-formylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 6 N-[(R)-1-[5-((R)-1-Acetylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-2-hydroxy-acetamide; compound 7 (S)-Morpholine-2-carboxylic acid [(R)-1-[5-((R)-1-acetylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]amide; compound 8 N-[(R)-1-[5-[(R)-1-Acetylamino-2-(1H-indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-2-amino-2-methyl-propionamide; compound 9 2-Amino-N-[(R)-1-[5-[(R)-1-formylamino-2-(1H-indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H-[1,2,4]-triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-2-methyl-propionamide; compound 10 N-[(R)-1-[5-((R)-1-Acetylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-2-amino-2-methyl-propionamide; compound 11 Pyridine-2-carboxylic acid [(R)-1-[5-[1-acetylamino-2-(1H-indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 12 2-Amino-N-[(R)-1-[5-((R)-1-formylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-2-methyl-propionamide; compound 13 Pyridine-2-carboxylic acid [(R)-1-[5-((S)-1-acetylamino-2-phenyl-ethyl)-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 14 Pyridine-2-carboxylic acid [(R)-1-[5-[1-formylamino-2-(1H-indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-amide; compound 15 {(R)-1-[5-[2-(1H-Indol-3-yl)-ethyl]-4-(4-methoxy-benzyl)-4H-[1,2,4]triazol-3-yl]-2-naphthalen-2-yl-ethyl}-carbamic acid tert-butyl ester; compound 16 1-{(R)-2-(1H-Indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-3-isopropyl-urea; compound 17 {(R)-2-(1H-Indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-carbamic acid isobutyl ester; compound 18 {(R)-2-(1H-Indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-carbamic acid tert-butyl ester; compound 19 1-Benzyl-3-{(R)-2-(1H-indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-urea; compound 20 1-Benzyl-3-{(R)-2-(1H-indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-thiourea; compound 21 [(R)-1-[4-(4-Fluoro-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester; compound 22 {(R)-2-(1H-Indol-3-yl)-1-[4-(4-isopropoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-carbamic acid tert-butyl ester; compound 23 {(R)-2-(1H-Indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-methyl-carbamic acid tert-butyl ester; compound 24 [(R)-1-[4-(2,4-Dimethoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester; compound 25 Piperidine-4-carbothioic acid {(R)-2-(1H-indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-amide; compound 26 2-Amino-N-{(R)-2-(1H-indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]triazol-3-yl]-ethyl}-thioacetamide; compound 27 Pyridine-2-carbothioic acid {(R)-2-(1H-indol-3-yl)-1-[4-(4-methoxy-benzyl)-5-phenethyl-4H-[1,2,4]-triazol-3-yl]-ethyl}-amide; and a physiologically tolerated salt thereof.