Patent ID: 7906491
Filing Date: 2011-03-15
Classification: A61K,A61P,C07H

Abstract:
1. A compound having the structural formula (I) wherein: R1 can be independently azido, alkyl, aryl, amido-alkyl, amido-aryl, O-alkyl, O-aryl, SH, 2-hydroxyethylthio, 2-aminoethylthio, S-aryl, NH-aryl, N-bisaryl or cycloalkylamino; R2 can be independently CI, Br, I, azido, O-alkyl, S-alkyl, NH-alkyl, N-bisalkyl, alkyl-carbamoyl or cycloalkylamino; R3 can be independently azido, amido-alkyl, amido-aryl, amino, NH-alkyl, NH-aryl, N-bisalkyl, N-bisaryl, NH-alkyl-carbamoyl or cycloalkylamino; and wherein R4 is O(H) or S(H); and R5 is O(H), S(H), amino, H, alkyl, O-alkyl, O-aryl, S-alkyl, S-aryl, NH-alkyl, NH-aryl, N-bisalkyl or N-bisaryl; or R4 is O(H), S(H), amino, H, alkyl, O-alkyl, O-aryl, S-alkyl, S-aryl, NH-alkyl, NH-aryl, N-bisalky or N-bisaryl; and R5 is O(H) or S(H); and pharmaceutically acceptable salts and/or hydrates thereof, with the proviso that the following named compounds are excluded: 2′-deoxyadenosine-3′,5′-cyclic amonophosphate; N 2′-deoxyadenosine-3′,5′-cyclic monophosphorothioate; 2′-deoxyadenosine-3′,5′-cyclic monophosphoroanilidate; 2′-deoxyadenosine-3′,5′-cyclic monophosphate methyl triester; 2′-deoxyadenosine-3′,5′-cyclic monophosphate ethyl triester; 2′-O-methyladenosine-3′,5′-cyclic monophosphate; 2′-O-ethyladenosine-3′,5′-cyclic monophosphate; 2′-O-n-propyladenosine-3′,5′-cyclic monophosphate; 2′-O-n-butyladenosine-3′,5′-cyclic monophosphate; 2′-O-iso-butyladenosine-3′,5′-cyclic monophosphate; 2′-O-methyladenosine-3′,5′-cyclic monophosphate methyl triester; and 2′-O-methyladenosine-3′,5′-cyclic monophosphate phenyl triester.