Patent ID: 6277833
Filing Date: 2001-08-21
Classification: A61P,C07C,C07D,C07F

Abstract:
A substituted triol of the formula (I):D--R (I)in whichD represents a heterocyclic radical formula: ##STR33##whereinR.sup.5 represents a phenyl which is unsubstituted or substituted 1 or 2 times by substituents independently selected from halogen, trifluoromethyl and straight-chain or branched alkyl having 1 to 8 carbon atoms;R.sup.10 represents cycloalkyl having 3 to 7 carbon atoms, or straight-chain or branched alkyl having 1 to 8 carbon atoms;R.sup.14 and R.sup.15 independently represent hydrogen, straight-chain or branched alkyl having 1 to 8 carbon atoms, or phenyl or benzyl, each of which phenyl or benzyl is unsubstituted or is substituted 1 to 2 times by substituents independently selected from halogen, trifluoromethyl, cyano, nitro and straight-chain or branched alkyl having 1 to 6 carbon atoms;R.sup.16 represents hydrogen, straight-chain or branched alkyl having 1 to 8 carbon atoms, and phenyl or benzyl, each of which phenyl or benzyl is unsubstituted or is substituted 1 to 2 times by substituents independently selected from halogen, trifluoromethyl, cyano, nitro and straight-chain or branched alkyl having 1 to 6 carbon atoms, or R.sup.16 represents pyridyl or a radical of the formula --CO--NH--L;whereinL represents phenyl which is unsubstituted or is substituted by halogen or trifluoromethyl;E represents an oxygen or sulfur atom, or a group of the formula .dbd.N--R.sup.10 ;R represents a radical of the formula: ##STR34##WHEREINX represents --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.ident.C--;R.sup.21, R.sup.22 and R.sup.23 independently represents a hyrdroxyl protective group, hydrogen or a radical of the formula --CO--R.sup.24 or --CO.sub.2 --R.sup.25 ;whereinR.sup.24 and R.sup.25 independently represents straight-chain or branched alkyl having 1 to 8 carbon atoms or phenyl; orR.sup.21 and R.sup.22 together form a radical of the formula: ##STR35##or a salt thereof;with the exception of the compounds of the formula: ##STR36##