Patent ID: 6323238
Filing Date: 2001-11-27
Classification: A61K,C07D

Abstract:
Benzopyranyl guanidine derivatives represented by the following formula 1, their stereochemical isomers and their pharmaceutically acceptable salts ##STR29##whereinR.sub.1 represents H, halogen, CF.sub.3, NO.sub.2, CN, OR.sup.a, O(C.dbd.O)R.sup.a, COOR.sup.a, NH.sub.2, NHS(O).sub.m R.sup.a, NH(C.dbd.O)R.sup.a or S(O).sub.m R.sup.a ; R.sup.a represents straight or branched alkyl group of C.sub.1 -C.sub.4 or aryl group; and m is an integer of 0-2,R.sub.2 represents straight or branched alkyl group of C.sub.1 -C.sub.4,R.sub.3 represents CH.sub.2 OR.sup.a, ##STR30##R.sup.a is defined as above; R.sup.b and R.sup.c are independent each other and represent straight or branched alkyl group of C.sub.1 -C.sub.4, respectively; and Z represents straight or branched alkyl group of C.sub.1 -C.sub.5,R.sub.4 represents OH, H, halogen, ONO.sub.2 or O(C.dbd.O)R.sup.a ; and R.sup.a is defined as above; R.sub.5 and R.sub.6 are independent each other and represent H, halogen, straight or branched alkyl group of C.sub.1 -C.sub.3, OR.sup.a, CX.sub.3, NO.sub.2, CO.sub.2 R.sub.a, --(C.dbd.O)R.sub.a or SO.sub.3 R.sup.a ; R.sup.a is defined as above; and X represents halogen, andn is an integer of 0-2.