Patent ID: 8586098
Filing Date: 2013-11-19
Classification: A61K,A61P

Abstract:
1. Drug loaded polymer particles having a homogeneous polymer composition from the centre to the periphery, having precipitated drug in a core region thereof, which drug has a water solubility of less than 0.1 g/1 at room temperature, and having a surface layer in the range of from 1 to 100 μm thick, wherein the ratio of the concentration of drug in the core:concentration of drug in the surface layer is at least 2:1, wherein the polymer composition consists essentially of water-insoluble water-swellable polymer capable of swelling in phosphate buffered saline at room temperature to an equilibrium water content of at least 75% measured gravimetrically, said polymer is substantially free of naturally-occurring polymer, the drug has a solubility in a solvent selected from dimethyl sulfoxide (DMSO), 1-methyl-2-pyrrolidinone (NMP), dimethyl formamide (DMF) and dioxane to a concentration of at least 10 1 times its solubility in water at room temperature. the water-insoluble water-swellable polymer is a polyvinyl alcohol, and said drug loaded polymer particles are substantially spherical and have sizes when equilibrated in phosphate buffered saline nor temperature in a range 100 to 1500μ.