Patent ID: 7589216
Filing Date: 2009-09-15
Classification: C07C,C07D,Y02P

Abstract:
1. A process for preparing a compound of the formula (VIII) comprising step A: contacting a compound of the formula (I) with a compound of the formula (II) in the presence of a carboxy activating agent, in a suitable solvent under conditions suitable to form a compound of the formula (III) followed by step B: contacting compound (III) with a compound of the formula (XIII) in the presence of a base in a suitable solvent, under conditions suitable to form a compound of the formula (IV) followed by Step C: contacting compound (IV) with a base in a suitable solvent under conditions suitable to form a compound of the formula (V) followed by Step D: contacting compound (V) with a compound of the formula (VI) in a suitable solvent optionally in the presence of an activator under conditions suitable to form a compound of the formula (VII) followed by Step E: contacting compound (VII) with a formylating agent in a suitable solvent under conditions suitable to form compound (VIII); wherein Y is a hydroxy protecting group; Each of R X is —CH G is —OH or —O R X′ is halo; R′ is alkyl or aryl; and n is 1.