Patent ID: 6028182
Filing Date: 2000-02-22
Classification: A61P,C07F,C07H

Abstract:
Compounds of the formula I, ##STR12## wherein Y is OH, SH, OAc or SAc, where Ac is a (C1-C1 8)-acyl, which is saturated or 1-3 times unsaturated,R' is aryl having 6 to 14 carbon atoms, heteroaryl having 3 to 13 carbon atoms and up to 3 heteroatoms selected from the group consisting of N, O and S, or alkyl,W is 5'-, 3' or 2' nucleoside analogue of a steroid, sugar, inositol, or peptide having at least one amino acid Ser or Tyr and a total of up to 20 natural amino acids,R has the meaning of W, where R and W can be identical or different, or R is an alkyl radical that is substituted or unsubstituted, orW and R, together with the phosphonate radical carrying them, form an oligonucleotide where W is a radical of the formula II and R is a radical of the formula II' ##STR13## where X is oxy, sulphanediyl or methylene,B independently of one another is a nucleotide base, n independently of one another is an integer from 0 to 50,R.sup.1 and R.sup.2 independently of one another are H, (C1-C18)acyl or a radical of the formula ##STR14## in which R.sup.4 is O.sup.-, S.sup.-, CH.sub.3 or CHYR', where R' and Y are as defined above and R.sup.5 is an alkyl radical that is substituted or unsubstituted having 1-18 carbon atoms,R.sup.3 is independently of one another H, O(C1-C18)-alkyl, O(C1-C18)-acyl, F, Cl, N.sub.3, NH.sub.2 or NHR.sup.6 where R.sup.6 is (C1-C6)-alkyl or -acyl and the curved bracket indicates that R.sup.3 and the adjacent phosphonyl radical can be in the 2' or 3' position.