Patent ID: 6146593
Filing Date: 2000-11-14
Classification: B01J,C12Q,G01N,G02B

Abstract:
A method for comparing relative copy number of nucleic acid sequences in two or more collections of nucleic acid molecules, said method comprising:(a) providing a biosensor wherein the biosensor comprises a plurality of optical fibers, each fiber including a sensor end and a transmission end where the sensor ends of the optical fibers bear target nucleic acids such hat the sensor end of at least one first fiber has attached a first target nucleic acid comprising a first target nucleotide sequence, and the sensor end of at least one second fiber has attached a second target nucleic acid, wherein said first and second target nucleic acids are different and are uniquely addressed;(b) contacting said biosensor with(i) a first collection of labelled nucleic acid molecules, and(ii) at least a second collection of labelled nucleic acid molecules;wherein the first and second labels are distinguishable from each other; and(c) comparing the amount of binding, if any, of the first and second collections of labelled nucleic acid molecules to said first target nucleic acid, thereby determining the relative copy number of any sequences in the first and second collections that are substantially complementary to said first target nucleotide sequence.