Patent ID: 6329368
Filing Date: 2001-12-11
Classification: A61K,A61P

Abstract:
A method for increasing the circulatory level of growth hormone in a mammalian host, the method comprising:administering to the host an ampakine, wherein the ampakine is a positive allosteric modulator of an AMPA receptor of the hypothalamus;whereby the circulatory level of growth hormone in the mammalian host increases, and wherein the positive allosteric modulator is a compound of the formula: ##STR8##wherein:R.sup.1 is N or CH;m is 0 or 1;R.sup.2 is (CR.sup.3.sub.2).sub.n-m or C.sub.n-m R.sup.3.sub.2(n-m)-2, in which n is 4, 5, or 6, and the R.sup.3 's in any single compound are the same or different; wherein:each R.sup.3 is H or C.sub.1 -C.sub.6 alkyl, or one R.sup.3 is combined with R.sup.4 to form a single bond linking the no. 6 and no. 3' ring vertices or to form a single divalent linking moiety linking the no. 6 and no. 3' ring vertices, any remaining R.sup.3 's being H or C.sub.1 -C.sub.6 alkyl, or one R.sup.3 is combined with R.sup.5 to form a single bond linking the no. 2 and no. 3' ring vertices or to form a single divalent linking moiety linking the no. 2 and no. 3' ring vertices, any remaining R.sup.3 's being H or C.sub.1 -C.sub.6 alkyl, wherein the linking moiety in the R.sup.3 definitions is CH.sub.2, O, NH or N(C.sub.1 -C.sub.6 alkyl);R.sup.4 when not combined with any R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkoxy;R.sup.5 when not combined with any R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkoxy;R.sup.6 is H, OH, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxy-(C.sub.1 -C.sub.6 alkyl), or C.sub.1 -C.sub.6 alkoxy-(C.sub.1 -C.sub.6 alkyl), or is combined with R.sup.7 ;R.sup.7 is H, OH, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxy-(C.sub.1 -C.sub.6 alkyl), C.sub.1 -C.sub.6 alkoxy-(C.sub.1 -C.sub.6 alkyl), amino, mono(C.sub.1 -C.sub.6 alkyl)amino, or di(C.sub.1 -C.sub.6 alkyl)amino, or is combined with R.sup.6 ; wherein R.sup.6 and R.sup.7 when combined form one of the following: ##STR9##wherein:R.sup.8 is O, NH or N(C.sub.1 -C.sub.6 alkyl);R.sup.9 is O, NH or N(C.sub.1 -C.sub.6 alkyl); andthe R.sup.10 's in any single compound are the same or different, and each R.sup.10 is H or C.sub.1 -C.sub.6 alkyl, wherein p is 1, 2, or 3, and q is 1 or 2.