Patent ID: 6713650
Filing Date: 2004-03-30
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating a disease state in a mammal that is alleviable by treatment with an agent capable of increasing ABCA-1 expression, comprising administering to a mammal in need thereof a therapeutically effective dose of a compound of the Formula I:R1â€”Xâ€”Yâ€”Zâ€”NR2R3â€ƒâ€ƒFormula I wherein: R1 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl; R2 and R3 are independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; or R2 and R3 when taken together with the nitrogen atom to which they are attached form a heterocyclic moiety; X is oxygen, sulfur, or â€”NR4â€”; Y is optionally substituted alkylene or a covalent bond; wherein R4 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, â€”S(O)2R5, â€”C(O)R5, or â€”C(O)NHR5, in which R5 is optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; and Z is â€”C(O)â€”Z1â€”, â€”C(S)â€”Z1â€”, or â€”SO2â€”Z1â€”; in which Z1 is lower alkylene or a covalent bond; with the proviso that i. when R1, R2, or R3 is alkenyl or alkynyl, the double bond of the alkenyl or the triple bond of the alkynyl is located at least two carbon atoms away from the attachment to the nitrogen; ii. when X is NR4, Y and Z1 are not both covalent bonds; and iii. when X is NR4, R3 and R4 are not both hydrogen.