Patent ID: 6800766
Filing Date: 2004-10-05
Classification: C07B,C07C,C07D,C07F

Abstract:
A method of hydrolytic kinetic resolution represented by Scheme 1: whereinthe terminal epoxide substrate is a racemic mixture; the salen catalyst is present in less than or equal to about 2 mol % relative to the racemic terminal epoxide substrate; M represents Co or Co(O2CRâ€³); H2O is present in less than or equal to about 55 mol % relative to the racemic terminal epoxide substrate; the diol product has an enantiomeric excess greater than or equal to about 70%; R represents independently for each occurrence H, alkyl, aralkyl, or aryl; Râ€² represents alkyl, haloalkyl, alkoxyalkyl, aralkyloxyalkyl, acyloxyalkyl, silyloxyalkyl, alkenyl, or aryl; and Râ€³ represents methyl or phenyl.