Patent ID: 6500849
Filing Date: 2002-12-31
Classification: C07C,C07D

Abstract:
A method of inhibiting bacterial or fungal growth in a mammal in need of bacterial or fungal growth inhibition which comprises administering to such a mammal a bacterial or fungal growth inhibiting effective amount of a compound of the formulaRCH(OR1)CH(NR2R3)R4 or RCH2CR35(NR2R3)R4 wherein R is wherein R5 is CH3(CH2)mC&Xgr;C, CH3(CH2)mCH&boxH;CH CH3(CH3)(CH2)mCH2CH2, wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, loweralkyl, loweralkoxy, halogen, or trifluoromethyl or wherein R23 is loweralkyl; R1 is hydrogen, loweralkyl, wherein R24 is loweralkyl or wherein R6 is hydrogen, loweralkyl, loweralkoxy, N(R21)2 wherein R21 is hydrogen,. loweralkyl, or wherein W is as above, or R2 is hydrogen or loweralkyl; R3 is hydrogen, loweralkyl or wherein R6 is as above or NHR27 wherein R27 is loweralkyl; R35 is wherein R36 is loweralkyl; R4 is wherein R7 is hydrogen or loweralkyl, C(R25)2OR8 wherein R8 is hydrogen, loweralkyl, or wherein R6 is as above and R25 is hydrogen or loweralkyl; R1 and R8 taken together with the oxygen to which they are attached from a group of the formula wherein R9 and R10 are independently hydrogen or loweralkyl; the optical isomers thereof, or the pharmaceutically acceptable salts thereof.