Patent ID: 6436679
Filing Date: 2002-08-20
Classification: A61K,A61P,C08B,C12P,Y10S

Abstract:
A method for the isolation of immunomodulatory carbohydrate composition, wherein said composition is comprised:(i) primarily (>95%) of polysaccharides derived from Aloe, said polysaccharides in said composition having an average molecular weight of 70-80 kDa with a range between 50-200 kDa; and (ii) said polysaccharides are comprised of D-galactose (approx. 5% or less), D-glucose (approx. 5% or less) and D-mannose (approximately 90%); said method comprising: (a) extracting Aloe gel juice from said Aloe species; (b) performing a controlled limited hydrolysis of total polysaccharide in said Aloe gel juice at a temperature and for a period of time suitable for controlled limited carbohydrate hydrolysis, wherein the immunomodulatory activity is maximized; (c) terminating said controlled limited hydrolysis; and (d) optionally decolorizing and filtering said Aloe gel juice.