Patent ID: 8150626
Filing Date: 2012-04-03
Classification: C12Q

Abstract:
1. A method for identification of differentially methylated genomic CpG dinucleotide sequences associated with adenocarcinoma in an individual, said method comprising: (a) obtaining a biological sample comprising genomic DNA from said individual; (b) measuring the level of methylation in said biological sample at a CpG dinucleotide sequence in a genomic target designated as SEQ ID NO: 265 and SEQ ID NO: 293; and (c) comparing the level of methylation at said genomic CpG dinucleotide sequences in the biological sample to a reference level of methylation of said genomic CpG dinucleotide sequences, wherein said reference level comprises the level of methylation at said genomic CpG dinucleotide sequences in a normal sample; wherein an increase in the level of methylation of said genomic CpG dinucleotide sequences in the biological sample for genomic target designated as SEQ ID NO: 265 and SEQ ID NO: 293 compared to the reference level identifies differentially methylated genomic CpG dinucleotide sequences associated with adenocarcinoma.