Patent ID: 6410576
Filing Date: 2002-06-25
Classification: A61K,C07D,C07K

Abstract:
A compound of formula [I] or a salt thereof, wherein R1 is lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, phenyl, phenyl-lower alkyl, phenyl-lower alkoxy, phenoxy, phenoxy-lower alkyl, amino, lower alkylamino or a nonaromatic heterocycle,R2 is hydrogen or lower alkyl or R2 joins with A1 through the carbon or sulfur to form a nonaromatic heterocycle, R3 is hydrogen, lower alkyl or phenyl or R3 joins with A1 through the carbon to form a nonaromatic heterocycle, R4 is hydrogen or lower alkyl, R5 is lower alkyl, halogeno-lower alkyl, hydroxy, lower alkoxy, phenyl, phenyl-lower alkoxy, phenoxy, carboxyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl or an aromatic heterocycle, A1 is lower alkylene, wherein the lower alkylene is unsubstituted or substituted by hydroxy, lower alkoxy, phenyl, phenoxy, carboxyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl or an aromatic heterocycle, provided that A1 is not CH(OH), A2 is lower alkylene substituted by phenyl, each said nonaromatic heterocycle is unsubstituted or substituted by lower alkyl, phenyl, phenyl-lower alkyl, amino, lower alkylamino or phenyl-lower alkylamino, and each said nonaromatic heterocycle is selected from the group consisting of pyrrolidine, piperidine, homopiperidine, octahydroazocine, pyrroline, piperazine, imidazolidine, imidazoline, pyrazolidine, pyrazoline, oxazolidine and thiazolidine, said aromatic heterocycle is selected from the group consisting of pyrrole, indole, isoindole, imidazole, pyrazole, oxazole, isoxazole, benzoxazole, thiazole, isothiazole, benzothiazole, pyridine, quinoline and pyrazine, each phenyl ring of said phenyl, said phenyl-lower alkyl, said phenyl-lower alkoxy, said phenoxy, said phenoxy-lower alkyl and said phenyl-lower alkoxycarbonyl is unsubstituted or substituted by halogen, lower alkyl, hydroxy, lower alkoxy, phenyl, phenoxy, carboxyl, lower alkoxycarbonyl, amino, lower alkylamino, nitro or cyano, each lower alkyl moiety of said lower alkylamino is unsubstituted or substituted by phenyl, amino or lower alkylamino.