Patent ID: 7081562
Filing Date: 2006-07-25
Classification: A01K,A61P,C07K,C12N,G01N

Abstract:
1. A mouse model with favorite onset of rheumatoid arthritis, obtained by (i) crossing a first mouse strain, having an inactivation of its endogenous immunoglobulin Fcγ receptor IIB gene, with a second mouse strain, wherein said second mouse strain is a wild-type collagen-induced arthritis-susceptible mouse strain, to obtain a mouse having a heterozygous inactivation of its endogenous immunoglobulin Fcγ receptor IIB gene, and (ii) performing one or more backcrosses, wherein the first backcross is carried out by breeding the heterozygous mouse obtained in step (i) with said second mouse strain to obtain a mouse having a heterozygous inactivation of its endogenous immunoglobulin Fcγ receptor IIB gene, and (iii) intercrossing the heterozygous mice obtained in the last backcross of the one or more backcrosses to produce a mouse having a homozygous inactivation of its endogenous immunoglobulin Fcγ receptor IIB gene, wherein onset of collagen-induced arthritis is observed when said mouse having a homozygous inactivation of its endogenous immunoglobulin Fcγ receptor IIB gene is immunized with type II collagen, thereby producing a mouse model with favorite onset of rheumatoid arthritis.