Patent ID: 6281214
Filing Date: 2001-08-28
Classification: A61P,C07C,C07D,C07F

Abstract:
A biphenyl compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR258##wherein R.sup.1 represents a hydroxyl group, an amino group, a cyano group, a pyrrolidyl group, a cyano lower alkyl group, a hydroxy lower alkyl group, a lower alkoxyalkyl group, a halogenated heteroarylalkyl group selected from the group consisting of a furfuryl group, and a pyridylmethyl group, wherein a halogen is attached to the heteroaryl ring, a lower acylalkyl group, a heteroarylalkoxyalkyl group selected from the group consisting of a furfuryl group, and a pyridylmethyl group to which the oxyalkyl is bonded, an aralkyloxyalkyl group selected from the group consisting of a benzyl group, a methylbenzyl group, a phenethyl group and a phenylpropyl group to which the oxyalkyl is bonded, an alkenyloxyalkyl group, a lower alkoxycarbonylalkyl group, a lower alkoxyalkoxyalkyl group, an arylhydroxyalkyl group selected from the group consisting of a benzyl group, a methylbenzyl group, a phenethyl group and a phenylpropyl group to which the hydroxyalkyl is bonded, a hydroxyheteroarylalkyl group selected from the group consisting of a furfuryl group, and a pyridylmethyl group, to which the hydroxyalkyl is bonded, a cycloalkylalkoxyalkyl group, alkenyl group, a halogenated alkenyl group, a halogenated aralkyl group selected from the group consisting of a benzyl group, methylbenzyl group, a phenethyl group and a phenylpropyl group, wherein a halogen is attached to the aryl ring, a halogenated hydroxyiminoaralkyl group wherein the aralkyl group is selected from the group consisting of a benzyl group, a methylbenzyl group, a phenethyl group and a phenylpropyl group, wherein a halogen is attached to the aryl ring, a lower alkoxy group lower alkoxyalkoxy group, an aryl group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, a nitrophenyl group and a cyanophenyl group, a heteroaryl group selected from the group consisting a furanyl group, a pyranyl group, and a pyridyl group, a formyl group, a lower acyl group, a pyridylacetyl and pyridylcarbonyl groups, an aralkylcarbonyl group selected from the group consisting of a benzyl group, a methylbenzyl group, a phenethyl group and a phenylpropyl group to which a carbonyl group is bonded, a cycloalkylalkylcarbonyl group, a heoeroarylalkylcarbonyl group, selected from the group consisting of a furfuryl group, and a pyridylmethyl group, to which a carbonyl group is bonded, a halogenated aralkylcarbonyl group selected from the group consisting of a benzyl group, a methylbenzyl group, a phenethyl group and a phenylpropyl group to which a carbonyl group is bonded and wherein a halogen is attached to the aryl ring, a lower alkoxycarbonyl group, a lower alkylamino group, a halogenated lower alkylsulfonylamino group, an arylsulfonylamino group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, nitrophenyl group and a cyanophenyl group to which a sulfonylamino group is bonded, a halogenated arylsulfonylamino group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, a nitrophenyl group and a cyanophenyl group to which a sulfonylamino group is bonded and wherein a halogen atom is bonded to the aryl ring, a tetrahydrofuranyl or tetrahydropyranyl group, a lower cyclic acetal group, a lower cyclic thioacetal group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, an aminosulfonyl group, a lower alkylaminosulfonyl group, an arylaminosulfonyl group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, a nitrophenyl group and a cyanophenyl group to which an aminosulfonyl group is bonded, a cycloalkylaminosulfonyl group, a halogenated lower alkylsulfonyl group, a halogenated aryloxy lower alkylsulfonyl group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, a nitrophenyl group and a cyanophenyl group bonded to an oxyloweralkylsulfonyl group and wherein a halogen atom is attached to the aryl ring or R.sup.1 is a cyano lower alkylsulfonyl group;R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a hydroxyl group or a lower alkoxy group;R.sup.3 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group, a halogenated lower alkyl group, a lower alkoxyalkyl group or a lower alkoxy group;R.sup.4 represents a hydrogen atom, a halogen atom, a hydroxy lower alkyl group, a hydroxyiminomethyl group or a formyl group;R.sup.5 represents a halogenated lower alkyl group, a hydroxy lower alkyl group or a lower alkoxycarbonyl group or an aryloxycarbonyl group selected from the group consisting of a phenyl group, a tolyl group, a xylyl group, a methoxyphenyl group, a chlorophenyl group, a bromophenyl group, a fluorophenyl group, a nitrophenyl group and a cyanophenyl group to which the oxycarbonyl group is bonded; andn is 0.