Patent ID: 6610685
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of formula wherein R1 is hydrogen or fluoro; R2 is selected from the group consisting of methyl, ethyl, cyclopropyl, heteroarylalkyl, alkoxyalkyl, 3-oxetanyl, 3-tetrahydrofuranyl, 2-tetrahydrofuranylmethyl, 3-tetrahydrofuranyl methyl and hydroxyalkyl, wherein hydroxyalkyl or alkoxyalkyl are optionally independently substituted with at least one substituent selected from the group consisting of monofluoromethyl, difluoromethyl, trifluoromethyl, alkoxy and hydroxy; R3 is hydrogen or fluoro; R4 is hydrogen or methyl; and n is 1, 2 or 3; or a pharmaceutically acceptable salt, solvate or ester thereof provided that at least one of R1 and R3 is fluoro when R2 is methyl.