Patent ID: 6767483
Filing Date: 2004-07-27
Classification: A61K

Abstract:
A method of preparing a lipid membrane, the method comprising:(a) providing a lipid membrane comprising a lipid monolayer, bilayer or multilayer; (b) providing a plurality of silyl lipid molecules integrally-associated with the lipid membrane of (a), wherein each silyl lipid molecule comprises at least one silanol group; and wherein said silyl lipid molecule is of the formula: (RO)nSiRâ€²m wherein: R is selected from a group consisting of C1-C50 alkyl; Râ€² is selected from a group consisting of (CH2)qA and OSiR3; A is selected from a group consisting of hydrogen, COOâˆ’, OH, COOH, N+R1R2R3, NHRâ€³, SH, SRâ€³ and C1-C50 alkyl; R1, R2, R3 and Râ€³ are selected from a group consisting of (CH2)qCH3 and (CH2)qSi(OR)3; q is a number from 1 to 50; n is a number from 1 to 4; and m is a number from zero to 3; and (c) cross-linking, via a siloxane bond, at least one silanol group from a first silyl lipid with at least one silanol group from a second silyl lipid; and (d) further cross-linking the silyl lipids to an encapsulating material or matrix.