Patent ID: 6228847
Filing Date: 2001-05-08
Classification: A61P,C07D,C07H

Abstract:
A method for decreasing T-cell function in a mammal comprising administering to the mammal a compound selected from the group consisting of: (1S)-1,4-dideoxy-1-C-(4-hydroxypyrrolo[3,2-d]pyrimidin-7-yl)-1,4-imino-D-r ibitol, or tautomer thereof, or a pharmaceutically acceptable salt thereof; and (1S)-1-C-(2-amino-4-hydroxypyrrolo[3,2-d]pyrimidin-7-yl)-1,4-dideoxy-1,4-i mino-D-ribitol, or tautomer thereof, or a pharmaceutically acceptable salt thereof, whereby said compound inhibits purine nucleoside phosphorylase.