Patent ID: 7871788
Filing Date: 2011-01-18
Classification: C07K,C12Q,G01N

Abstract:
1. A method of determining a grade of malignancy of a test cancer cell, the method comprising the following steps: detecting an intranuclear amount and intracytoplasmic amount of a first region corresponding to exon 10 of an ATBF1 gene and/or a second region corresponding to exon 11 of an ATBF1 gene in the test cancer cell; and determining a grade of malignancy of the test cancer cell according to the following criteria: (a) the grade of malignancy is low when the first region is localized mainly in a nucleus, (b) the grade of malignancy is high when the first region is localized mainly in a cytoplasm, (c) the grade of malignancy is higher than that of (b) when the first region is absent both in the cytoplasm and in the nucleus, (d) the grade of malignancy is low when the second region is localized mainly in the nucleus, and (e) the grade of malignancy is high when the second region is localized mainly in the cytoplasm.