Patent ID: 7740833
Filing Date: 2010-06-22
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for treating an autoimmune or inflammatory disease comprising the administration of an effective amount of a monomeric variant to an individual having an autoimmune or inflammatory disease, wherein Monocyte Chemoattractant Protein 1 (MCP-1) signaling is involved in the autoimmune or inflammatory disease process and said monomeric variant comprises: a) SEQ ID NO: 2 (CCL2-P8A); b) SEQ ID NO: 4 (CCL2*-P8A): c) SEQ ID NO: 2 or SEQ ID NO: 4 with the substitution of a Cysteine in position 8, 14 or 17; d) SEQ ID NO: 2 or SEQ ID NO: 4 with the substitution of an Alanine or a Glycine in position 1; or e) SEQ ID NO: 2 or SEQ ID NO: 4 with the addition of a Cysteine at the C-terminus.