Patent ID: 7981883
Filing Date: 2011-07-19
Classification: A61P,C07D

Abstract:
1. A substituted spiro compound corresponding to formula I wherein n is 0, 1 or 2; and I.) R 1 denotes: a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; or an unsubstituted or mono- or polysubstituted, unsaturated or saturated cycloaliphatic group which optionally contains one or more heteroatoms as ring members, and which optionally may be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally containing one or more heteroatoms as chain members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system, wherein the cycloaliphatic group is optionally substituted with one or more substituents independently selected from the group consisting of oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF an unsubstituted or mono- or polysubstituted aryl or heteroaryl group which optionally may be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally containing one or more heteroatoms as chain members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; or a —C(═O)—NR and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 each independently denote hydrogen, or a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; or II.) R and R 2 , R 4 , R 5 , R 6 , R 7 and R 8 each independently denote hydrogen, or a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; or R 1 , R 2 , R 7 and R 8 each denote hydrogen, and R 3 , R 4 , R 5 and R 6 each independently denote a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; and R 9 denotes hydrogen, or a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; or an unsubstituted or mono- or polysubstituted, unsaturated or saturated cycloaliphatic group which optionally contains one or more heteroatoms as ring members, and which optionally may be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally containing one or more heteroatoms as chain members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; or an unsubstituted or mono- or polysubstituted aryl or heteroaryl group which optionally may be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally containing one or more heteroatoms as chain members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; R 10 denotes: a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group optionally containing one or more heteroatoms as chain members; or an unsubstituted or mono- or polysubstituted phenyl group, with the proviso that either of the two meta positions and the para position of said phenyl group are not both substituted with substituents which are bound to the phenyl group via identical atoms selected from the group consisting of oxygen, sulfur and nitrogen; or an unsubstituted or mono- or polysubstituted group selected from the group consisting of naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyranyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, benzotriazolyl, benzisoxazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl; 2H-benzo[1.4]oxazin-3(4H)-onyl, (3,4)-dihydroquinolin-2(1H)-onyl, [3,4]-dihydro-2H-1,4-benzoxazinyl and benzothiazolyl; or an unsubstituted or mono- or polysubstituted aryl or heteroaryl group which is bound via a —(CH a —C(═O)—NR R 11 and R 13 each independently denote: a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group; or an unsubstituted or mono- or polysubstituted, unsaturated or saturated cycloaliphatic group which optionally contains one or more heteroatoms as ring members, and which optionally may be bound via a —(CH an unsubstituted or mono- or polysubstituted aryl or heteroaryl group which optionally may be bound via a —(CH R 12 and R 14 each independently denote hydrogen, or a linear or branched, saturated or unsaturated, unsubstituted or mono- or polysubstituted aliphatic group; an unsubstituted or mono- or polysubstituted, unsaturated or saturated cycloaliphatic group which optionally contains one or more heteroatoms as ring members, and which optionally may be bound via a linear or branched, unsubstituted or mono- or polysubstituted alkylene, alkenylene or alkinylene group optionally containing one or more heteroatoms as chain members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; or or an unsubstituted or mono- or polysubstituted aryl or heteroaryl group which optionally may be bound via a —(CH or R 11 and R 12 , or R 13 and R 14 , respectively, together with the nitrogen atom to which they are bound form an unsubstituted or mono- or polysubstituted, unsaturated or saturated heterocycloaliphatic ring which optionally contains one or more further heteroatoms as rign members, and which optionally may be condensed with an unsubstituted or mono- or polysubstituted mono- or polycyclic ring system; wherein substituents of the above-mentioned heterocycloaliphatic group formed by R substituents of the above-mentioned aliphatic groups are independently selected from the group consisting of F, Cl, Br, I, —CN, —NO or a salt or solvate thereof.