Patent ID: 6380430
Filing Date: 2002-04-30
Classification: A61P,C07C

Abstract:
A compound of formula I in whichR1, R4 in each case independently of one another are â€”C(&boxH;NH)â€”NH2, which is optionally monosubstituted by â€”COA, â€”COâ€”[C(6)2]nâ€”Ar, â€”COOA, â€”OH or a conventional amino protective group, â€”NHâ€”C(&boxH;NH)â€”NH2, â€”COâ€”N&boxH;C(NH2)2, R2, R3, R5 in each case independently of one another are H, A, OR6, N(R6)2, NO2, CN, Hal, NHCOA, NHCOAr, NHSO2A, NHSO2Ar, COOR6, CON(R6)2, CONHAr, COR6, COAr, S(O)nA, S(O)nAr, â€”Oâ€”[C(R6)2]mâ€”COOR6, â€”[C(R6)2]pâ€”COOR6, â€”Oâ€”[C(R6)2]mâ€”CON(R6)2, â€”[C(R6)2]pâ€”CON(R6)2, â€”Oâ€”[C(R6)2]mâ€”CONHAr, or â€”[C(R6)2]pâ€”CONHAr, X is â€”CH2â€”, â€”CH2CH2â€”, â€”CR6&boxH;CR6â€”, â€”[C(R6)2]nâ€”Oâ€”, â€”Oâ€”[C(R6)2]nâ€”, â€”COOâ€”, â€”OOCâ€”, â€”CONR6â€” or â€”NR6COâ€”R6 is H, A or benzyl, A is alkyl having 1-20 C atoms, in which one or two CH2 groups are optionally replaced, in each case independently by O or S atoms or by â€”CR6&boxH;CR6â€” groups, and optionally 1-7 H atoms can be replaced by F, Ar is phenyl or naphthyl, which is unsubstituted or mono-, di- or trisubstituted by A, Arâ€², OR6, OArâ€², N(R6)2, NO2, CN, Hal, NHCOA, NHCOArâ€², NHSO2A, NHSO2Arâ€², COOR6, CON(R6)2, CONHArâ€², COR6, COArâ€², S(O)nA or S(O)nArâ€², Arâ€² is phenyl or naphthyl, which is unsubstituted or mono-, di- or trisubstituted by A, OR6, N(R6)2, NO2, CN, Hal, NHCOA, COOR6, CON(R6)2, COR6 or S(O)nA, Hal is F, Cl, Br or I, n is 0, 1 or 2, m is 1 or 2, p is 1 or 2, and salts thereof.