Patent ID: 6900207
Filing Date: 2005-05-31
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula (I-1A) wherein R is (i) hydrogen, (ii) C1-8 alkyl, (iii) CycA, (iv) C1-8 alkyl substituted with a group selected from halogen, CycA, nitro, CF CycA is a mono-, bi- or tri-cyclic C3-15 carboning or a mono-, bi- or tri-cyclic 3-15 membered heteroring containing 1-4 of nitrogen, 1-2 of oxygen and/or 1 of sulfur; R (1) C1-8 alkyl, (2) C2-8 alkenyl, (3) C2-8 alkynyl, (4) CycA or (5) C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl substituted with agroup selected from halogen, nitro, CF R AA (i) a single bond, or wherein R (i) hydrogen, (ii) C1-8 alkyl, (iii) CycA or (iv) C1-8 alkyl substituted with 1-5 of a group selected from the following (1)-(8): (1) —NR (2) —OR (3) —SR (4) —COR (5) —NR (6) guanidino, (7) CycA, and (8) —NR R R R R R R AA is a 5-12 membered mono- or bi-cyclic heteroring and the other symbols have the same meanings as above, AA (i) a single bond, wherein R (1) hydrogen, (2) C1-8 alkyl, (3) CycA or (4) C1-8 alkyl substituted with 1-5 of a group selected from the following (a)-(h): (a) —NR R R R R R R R CycC is a 3-17 membered mono- or bi-cyclic heteroring, CycD is a C3-14 mono- or bi-cyclic carboring or a 3-14 membered mono- or bi-cyclic heteroring, or AA wherein CycE is a 4-18 membered mono- or bi-cyclic heteroring, CycF is a 5-8 membered monocyclic heteroring, and the other symbols have the same meanings as above, R (i) hydrogen, (ii) C1-8 alkyl, (iii) phenyl or, (iv) C1-8 alkyl substituted with 1-5 of a group selected from —NH wherein one carbon atom may be replaced by oxygen, sulfur or —NR R R R R q is an integer of 1-4, Z is a single bond, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, —O—, —S—; —CO—, —SO—, —SO E is hydrogen atom, halogen atom, CF R R R G is C3-10 mono- or bi-cyclic carboring or 5-18 membered mono-, bi- or tri-cyclic heteroring containing 1-3 of nitrogen, 1 of oxygen and/or 1 of sulfur, r is an integer of 1-5, R R R R R with proviso that (i) when Z is —SO—, E is not hydrogen, and (ii) CycA in R, R R (1) C1-8 alkyl, (2) halogen atom, (3) —NR (4) —OR (5) a C5-10 mono-or bi-cyclic carboring, (6) nitro, (7) CF (8) cyano, (9) a 5-10 membered mono- or bi-cyclic heteroring, (10) —SR (11) —COR (12) oxo, (13) —SO (14) —OCF (15) C1-8 alkyl substituted with 1-5 of a group selected from the following (a)-(m): (a) halogen, (b) —NR wherein R R R