Patent ID: 8956824
Filing Date: 2015-02-17
Classification: C12Q,G01N

Abstract:
1. A method of identifying an allosteric modulator of a SH2-containing inositol-5′-phosphatase (SHIP) polypeptide, the method comprising: a) providing a SHIP polypeptide, or fragment or variant thereof, wherein the SHIP polypeptide or the fragment or variant thereof comprises an allosteric site that comprises a SHIP C2 domain and a SHIP pleckstrin homology (PH) domain; b) contacting the SHIP polypeptide, or the fragment or variant thereof, with a test compound; and c) determining whether the test compound specifically binds the allosteric site, wherein the test compound is determined to be an allosteric modulator of the SHIP polypeptide if the test compound specifically binds the allosteric site.