Patent ID: 7388078
Filing Date: 2008-06-17
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An isolated polypeptide having the biological activity of chemotaxis inhibitory protein from Staphylococcus aureus (“CHIPS activity”) on complement factor 5a (C5a)-binding, wherein the polypeptide is encoded by a nucleotide sequence selected from the group consisting of: a) a nucleotide sequence comprising the sequence of nucleotides 125-490 as depicted in b) nucleotide sequences encoding a polypeptide having CHIPS activity and having the amino acid sequence depicted in c) nucleotide sequences having at least 90% sequence identity with any one of the nucleotide sequences in a) or b), wherein the polypeptide is not isolated from the natural producing host cell and wherein CHIPS activity is measured by the ability of the polypeptide to prevent the binding of the fluorescent-C5a to neutrophils as determined by flow cytometry.