Patent ID: 8241669
Filing Date: 2012-08-14
Classification: A61K,A61P

Abstract:
1. A method for the preparation of an endoparasiticidal gel composition comprising about 1.0% to 3.5% wt/wt of moxidectin; about 10.0% to 15.0% wt/wt of praziquantel; about 4.0% to 24.0% wt/wt of benzyl alcohol; about 1.0% to 34.0% wt/wt of ethanol; about 2.0% to 15.0% wt/wt of colloidal silicon dioxide; about 1.0% to 20.0% wt/wt of a surfactant; and about 35.0% to 61.0% wt/wt of an oil, which comprises the following steps: a). dissolving a thickener in a mixture of benzyl alcohol and ethanol to form a solution A; b). mixing an oil with praziquantel to form a suspension B: c). admixing solution A with suspension B at temperatures ≦50° C. until a solution C which is homogeneous at room temperature is obtained; d). admixing surfactant and optionally butylated hydroxytoluene with solution C to form solution D; and, e). sequentially admixing moxidectin and colloidal silicon dioxide to solution D to form gel E, wherein gel E is a non-aqueous composition.