Patent ID: 6245759
Filing Date: 2001-06-12
Classification: A61K,A61P,C07D

Abstract:
A compound in accordance with formula 1: ##STR16##or a pharmaceutically acceptable salt or stereoisomer thereof, whereinR.sub.1 is phenyl or thienyl, said phenyl and thienyl optionally substituted with one to three substituents selected from R.sup.a ;R.sub.2, R.sub.3, and R.sub.5 are independently selected from H or C1-6 alkyl; R.sub.7 and R.sub.8 are independently selected from:2) C.sub.1-6 alkyl,3) COR,4) COOR, and5) Phenyl; orNR.sub.7 R.sub.8 can be taken together to form a heterocyclic 5-7 membered saturated or unsaturated ring consisting of, in addition to the nitrogen atom, one to two additional non-adjacent heteroatoms selected from N, O and S, said ring optionally substituted with one or two substituents selected from R.sup.a ;R.sub.10 is:1) H,2) C.sub.1-6 alkyl,3) NR.sub.7 R.sub.8,4) O-C.sub.1-6 alkyl5) phenyl,6) morpholinyl,7) piperizinyl, or6) piperidinyl;said alkyl, phenyl, morpholinyl, piperzinyl, and piperidinyl is optionally substituted with one to three members selected from Ra;R.sup.a is:1) C.sub.1-10 alkyl,2) halogen,3) NO.sub.2,4) OR,5) NR.sub.7 R.sub.8,6) CN,7) phenyl,8) morpholinyl,9) piperizinyl, or10) piperidinyl;R is H or C.sub.1-6 alkyl.