Patent ID: 8697854
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated nucleic acid molecule coding for the V(D)J regions of a T cell receptor (TCR) that recognizes tyrosinase and comprising the nucleic acid sequence of SEQ ID NO: 1 coding for the α-chain and/or the nucleic acid sequence of SEQ ID NO: 2 coding for the β-chain of said TCR, or a derivative thereof, wherein the α- and β-chain coding sequence is derived from SEQ ID NO: 1 and SEQ ID NO: 2, respectively, by codon optimization, or a fragment thereof coding for a CDR3 region of a TCR recognizing tyrosinase and having the nucleic acid sequence of SEQ ID NO: 3 or 4 or coding for the amino acid sequences of SEQ ID NO: 5 or 6.