Patent ID: 9096650
Filing Date: 2015-08-04
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An internally-constrained cyclic oligopeptide comprising a ring of ten amino acids for specifically binding to a target ligand, wherein the ring comprises two amino acid domains, each domain comprising four epitope-forming amino acids, and two associating functional groups positioned so that they form one or more intra-cyclic non-covalent associations; whereby the cyclic oligopeptide is constrained in a single conformation so that the epitope-forming amino acids form an epitope in each domain, each epitope being capable of specifically binding to a target ligand, wherein the cyclic oligopeptide has the following structure: wherein A, B, C, D, W, X, Y and Z represent the epitope-forming amino acids; one epitope is formed from the domain D-C-A-B and one epitope is formed from the domain Z-X-Y-W; and the Z-X-Y-W domain and/or the D-C-A-B domain is selected from the group consisting of YEKA (SEQ ID NO: 1), YEAK (SEQ ID NO: 2), YAKE (SEQ ID NO: 3), YAEK (SEQ ID NO: 4), YKAE (SEQ ID NO: 5), YKEA (SEQ ID NO: 6), EYKA (SEQ ID NO: 7), EYAK (SEQ ID NO: 8), EKAY (SEQ ID NO: 9), EKYA (SEQ ID NO: 10), EAKY (SEQ ID NO: 11), EAYK (SEQ ID NO: 12), KAYE, (SEQ ID NO: 13) KAEY (SEQ ID NO: 14), KYAE (SEQ ID NO: 15), KYEA (SEQ ID NO: 16), KEAY (SEQ ID NO: 17), KEYA (SEQ ID NO: 18), AKEY (SEQ ID NO: 19), AKYE (SEQ ID NO: 20), AYEK (SEQ ID NO: 21), AYKE (SEQ ID NO: 22), AEYK (SEQ ID NO: 23) and AEKY (SEQ ID NO: 24); and each Σ is a lipidic amino acid with a linear hydrocarbon side chain associating functional group comprising a hydrocarbon chain between 8 and 20 carbons in length.