Patent ID: 6528509
Filing Date: 2003-03-04
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein;R1 is selected from R, halogen, N(R8)2, OR, NRCOR, NRCON(R8)2, CON(R8)2, SO2R, NRSO2R, or SO2N(R8)2; T is selected from a valtence bond or a linker group selected from: â€”Oâ€”, â€”Sâ€”, â€”NH2â€”, or an optionally substituted C1-6 alkylidene chain wherein up to two saturated carbons of the chain are optionally replaced by â€”C(&boxH;O)â€”, â€”CONHâ€”, CONHNHâ€”, â€”CO2â€”, â€”NHCO2â€”, â€”Oâ€”, â€”NHCONHâ€”, â€”OC(&boxH;O)â€”, â€”OC(&boxH;O)NHâ€”, â€”NHNHâ€”, â€”NHCOâ€”, â€”Oâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”NHâ€”, â€”SO2NHâ€”, or NHSO2â€”; each R is independently selected from hydrogen or an optionally substituted aliphatic group having one to six carbons; R2 is selected from hydrogen, CN, halogen, aryl, aralkyl, heteroaryl, heterocyclyl, an optionally substituted acyclic aliphatic chain group having one to six carbons, or an optionally substituted cyclic aliphatic group having four to ten carbons; R3 is selected from R, OH, OR, N(R8)2, halogen, or CN; Q is J; J is â€”C(&boxH;O)â€”; R4 is â€”NHR5; R5 â€”(CH2)yCH(R6) (R7); y is 0-6; R6 is an optionally substituted group selected from an aryl, aralkyl, aralkoxy, heteroaryl, heteroarylalkyl, heteroarylalkoxy, heterocyclyl, heterocyclylalkyl, or heterocyclylalkoxy, group; R7 is independently selected from an optionally substituted aliphatic, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, or alkoxycarbonyl; each R8 is independently selected from R, or two R8 on the same nitrogen taken together with the nitrogen optionally form a four to eight membered, saturated or unsaturated heterocyclic ring having one to three heteroatoms; and each substitutable ring nitrogen is optionally substituted by R, NR2, COR, CO2(C1-C6 optionally substituted alkyl), SO2 (C1-C6 optionally substituted alkyl) , CONR2, and SO2NR2.