Patent ID: 8853212
Filing Date: 2014-10-07
Classification: A61P,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein r is an integer selected from 0, 1, and 2; V is selected from the group consisting of: Ar is phenyl optionally substituted with one to five R each R each R wherein any individual methylene (CH R R or R R wherein alkyl and cycloalkyl are optionally substituted with one to five fluorines and wherein aryl and heteroaryl are optionally substituted with one to five substituents independently selected from the group consisting of hydroxy, halogen, cyano, nitro, CO C R wherein alkyl and cycloalkyl are optionally substituted with one to three substituents independently selected from fluorine and hydroxyl, and heteroaryl is optionally substituted with one to two substituents independently selected from the group consisting of hydroxy, halogen, cyano, nitro, CO R p is an integer selected from 0 and 1; each n is an integer independently selected from 0, 1, and 2; and each m is an integer independently selected from 0, 1, and 2.