Patent ID: 6432660
Filing Date: 2002-08-13
Classification: C12N,Y10S

Abstract:
A method for screening for modulators of HsKif12a, the method comprising the steps of:(i) providing biologically active HsKif12a, which has the following properties: (i) activity including microtubule stimulated ATPase activity; and (ii) sequence that has greater than 90% amino acid sequence identity to HsKif12a of SEQ ID NO:2 as measured using a sequence comparison algorithm; (ii) contacting biologically active HsKif12a with a candidate agent in a test and control concentration; and (iii) assaying for the level of HsKif12a activity, wherein the HsKif12a activity is selected from the group consisting of binding activity or ATPase activity, and wherein a change in activity between the test and control concentration indicates a modulator.