Patent ID: 6071969
Filing Date: 2000-06-06
Classification: A61K,A61P,C07C,Y02A

Abstract:
A method for treating or preventing a disease of the nervous system in which the pathophysiology of the disorder involves excessive release of a neurotransmitter from neuronal cells comprising the administration to a mammal exhibiting symptoms of such disorders or susceptible to such disorders, an effective amount of a compound having the formula: ##STR26## or a tautomer thereof, wherein R and R.sup.1 are the same or different and are cycloalkyl of 3 to 12 carbon atoms;wherein R and R.sup.1 are optionally substituted by hydroxy, acetate, oxo, amino, lower C.sub.1-6 alkyl, lower C.sub.1-6 alkyl amino, alkoxy of 1-6 carbon atoms, di-lower C.sub.2-12 alkyl amino, nitro, azido, sulfhydryl, cyano, isocyanato, halogen, amido, sulfonato or carbamido; R.sup.6 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.12 cycloalkyl, carbocyclic aryl, nitrile, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.1 -C.sub.6 acyl or benzoyl.