Patent ID: 8372397
Filing Date: 2013-02-12
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method for increasing engraftment of a population of hematopoietic stem or progenitor cells in a mammalian subject comprising: (a) selecting a mammalian subject in need of an increase in hematopoietic stem or progenitor cells; (b) treating a population of hematopoietic stem or progenitor cells in vitro with a Wnt/β-catenin signal-promoting agent; and (c) administering the treated population of hematopoietic stem or progenitor cells to the selected mammalian subject; wherein the engraftment of the treated population of hematopoietic stem or progenitor cells is increased in the selected mammalian subject compared to an untreated population of hematopoietic stem or progenitor cells.