Patent ID: 6780600
Filing Date: 2004-08-24
Classification: C07K,G01N

Abstract:
A screening assay for identifying a compound that interferes with binding of a synaptic activation protein to a metabotropic glutamate receptor (mGluR), comprising:a) adding a test compound to a reaction mixture comprising (i) an isolated synaptic activation protein having at least 70% sequence identity to a polypeptide comprising SEQ ID NO: 2, and (ii) an isolated mGluR comprising SSSL (SEQ ID NO: 10) or SSTL (SEQ ID NO: 11), wherein the synaptic activation protein binds to the mGluR in the absence of the test compound, and b) detecting a change in binding between the synaptic activation protein and the mGluR in the presence of the test compound as compared to the absence of the test compound, thereby identifying a compound that interferes with binding the synaptic activation protein and the mGluR.