Patent ID: 8278285
Filing Date: 2012-10-02
Classification: A61P,C07K,C12Q

Abstract:
1. A method for inhibiting proliferation of gastric tumor cells comprising administering to said tumor cells an effective amount of a ZNF312b (Zinc finger protein 312b) gene expression inhibitor, wherein the ZNF312b gene expression inhibitor is: an antisense polynucleotide with a complementary sequence to the mRNA transcribed from a ZNF312b gene comprising the nucleotide sequence as set forth in SEQ ID NO:1 or a fragment thereof containing the carboxy-terminal region of ZNF312b gene comprising the nucleotide sequence coding the amino acid sequence as set forth in SEQ ID NO:20, thereby specifically inhibiting expression of the ZNF312b gene, a siRNA (small interfering RNA) molecule which comprises a sequence having the complementary sequence to the mRNA transcribed from the ZNF312b gene comprising the nucleotide sequence as set forth in SEQ ID NO:1 or a fragment thereof containing the carboxy-terminal region of the ZNF312b gene comprising the nucleotide sequence coding the amino acid sequence as set forth in SEQ ID NO:20, thereby specifically inhibiting expression of the ZNF312b gene.