Patent ID: 6749866
Filing Date: 2004-06-15
Classification: A61K,C12Y,Y10S

Abstract:
A composition for the modulated release of a biologically active pharmaceutical agent, comprising:a) a biocompatible and biodegradable polymeric matrix; b) an effective amount of a biologically active pharmaceutical agent, the biologically active pharmaceutical agent being dispersed within the polymeric matrix; and c) a metal cation component for modulating the release of the biologically active agent from the polymeric matrix, wherein said metal cation component is selected from the group consisting of magnesium hydroxide, magnesium carbonate, calcium carbonate, zinc carbonate, magnesium acetate, zinc acetate, magnesium chloride, zinc chloride, magnesium sulfate, zinc sulfate, magnesium citrate and zinc citrate, the metal cation component is separately dispersed within the polymeric matrix and the biologically active agent is present from about 0.01% (w/w) to about 50% (w/w) of the composition.