Patent ID: 8076505
Filing Date: 2011-12-13
Classification: A61P,C07C

Abstract:
1. A process for preparing a compound represented by formula (Ia) or a pharmaceutically acceptable salt thereof: said process comprising: (i) reacting a compound represented by formula (IIa): wherein X′ is selected from the group consisting of chlorine, bromine, iodine, and a triflate group, with a compound represented by formula (IIIa): to obtain a compound represented by formula (IVa): (ii) submitting said compound represented by formula (IVa) to radical bromination to obtain a compound of formula (Va): (iii) transforming said compound represented by formula (Va) into a nitrile compound represented by formula (VIa): (iv) reacting said compound represented by formula (VIa) with 1,2-dibromoethane to obtain a compound represented by formula (VIIa): (v) hydrolyzing said compound represented by formula (VIIa) to obtain said compound represented by formula (Ia) or a pharmaceutically acceptable salt thereof.