Patent ID: 6677325
Filing Date: 2004-01-13
Classification: A61K,C07D,C07J

Abstract:
A method for inhibiting estrone or estradiol production, or both, in a subject in need thereof comprising administering a ring system compound comprising a sulfamic ester group, wherein the compound is of formula (II), wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, and at least one of R1 and R2 is H, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and the ring system ABCD represents a substituted or unsubstituted, saturated or unsaturated steroid nucleus, selected from the group consisting of oestrones, dehydroepiandrosterone, substituted oestrones, oestradiols, substituted oestradiols, oestriols or substituted oestriols; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2), or a pharmaceutically acceptable salt thereof.