Patent ID: 6465647
Filing Date: 2002-10-15
Classification: A61P,C07C,C07F

Abstract:
A compound having the structure in accordance with a formula selected from the group consisting to formulas 1, 2, 3 and 4, wherein R, R1, R2 and R3 are H, lower alkyl of 1 to 10 carbons, cycloalkyl of 3 to 10 carbons, halogen, (C1âˆ’10-lower alkyl)3-silyl, C1âˆ’10-lower alkylphenyl, or phenyl-C1âˆ’10-lower alkyl,n is an integer having the values of 0 to 6; W is O, S, C(R)2, CRCO2R, NR, NOR, NN(R)2; W1 is OR, SR, N(R)2, RC(O)O, RC(S)O, RC(O)S, NRC(O)R, NRC(S)R, NRC(O)N(R)2, NRC(S)N(R)2, OC(O)OR, and SC(O)OR; X is Câ‰¡C, C(O)O, C(O)S, CONR, CSNR, and (CR=CR)nâ€² where nâ€² is an integer having the values 1 to 5; Y is heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said heteroaryl group being optionally substituted with one or two R groups; A is (CH2)q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, â€”CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, â€”COR7, CR7(OR12)2, CR7OR13O, or tri-lower alkylsilyl, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons or (trimethylsilyl)alkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alky, and R13 is divalent alkyl radical of 2-5 carbons, or a pharmaceutically acceptable salt of said compound.