Patent ID: 6495124
Filing Date: 2002-12-17
Classification: A61K,A61Q

Abstract:
A composition effective for the treatment or inhibiting of fungal infections of nails, comprising:(a) at least one antifungal agent effective in the treatment or prevention of onychomycoses; (b) a plasticizing and penetration enhancing effective amount of a compound of the following formula (I): A is [is] a group having the structure m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, R represents hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms, and, R1, R2, R3, R4, R5 and R6, each, independently, represent hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms, with the proviso that only one R1 to R6 may be said alkyl group, and with the further proviso that, when p, q and r have a value of 0, m+n is at least 11; (c) water-insoluble, film-forming polymer; and, (d) volatile solvent; the composition, when applied to nails, forming, upon evaporation of the volatile solvent, a hard, water-resistant film from which the antifungal agent is releasable and becomes available to treat or prevent fungal infection.