Patent ID: 7758871
Filing Date: 2010-07-20
Classification: A61K,A61N,A61P,Y02A

Abstract:
1. A method of reducing neurotransmitter release in a subdermal structure of a patient, the method comprising the steps of: (a) non-chemically disrupting the stratum corneum of the patient's skin to reduce impermeability of the stratum corneum: (b) applying a fluid to the patient's skin; (c) applying a transdermal patch to the skin of the patient in an area that had the stratum corneum disrupted in step (a), the transdermal patch comprising; (d) solubilizing the botulinum toxin provided in the dry state with the fluid, wherein solubilization of the botulinum toxin permits diffusion of the botulinum toxin from the adhesive layer into the patient's skin thereby reducing neurotransmitter release in a subdermal structure.