Patent ID: 6646150
Filing Date: 2003-11-11
Classification: C07C,Y02P

Abstract:
A process for producing an (aminomethyl)trifluoromethyl-carbinol derivative of the formula (I): wherein R1 is a group corresponding to the side chain of a natural or non-natural &agr;-amino acid, R2 is a hydrogen atom or R21 (in which R21 is a protecting group for amino group having a carbonyl group at the binding site to the nitrogen atom), provided that when a functional group exists in R1, then such functional groups may optionally be protected, or an acid addition salt thereof, which comprises reducing a 5-hydroxy-5-trifluoromethyl-1,3-oxazolidine derivative of the formula (II): wherein R1 and R21 are as defined above, removing a protecting group for amino group R21 from the product to give a compound of the formula (I) wherein R2 is a hydrogen atom if necessary, then followed by converting the product into an acid addition salt thereof, if necessary.