Patent ID: 7501416
Filing Date: 2009-03-10
Classification: C07D

Abstract:
1. A compound of Formula 1 or Formula 2: or a pharmaceutically acceptable salt or ester form thereof, wherein: Y Y R R n is from 1 to 4; A is O(R R R m is from 1 to 5; R R wherein: “alkyl” refers to a monovalent alkane (hydrocarbon) derived radical containing from 1 to 12 carbon atoms; and where an alkyl includes both substituted and unsubstituted alkyl groups wherein the substituents may be selected from alkyl, aryl, halo haloalkyl, alkoxy, alkylthio, hydroxy, carboxy, alkylcarbonyl, alkyloxycarbonyl, alkylcarbonyloxy, amino, carbamoyl, urea, and thiol; “aklenyl” refers to hydrocarbon radical straight, branched or cyclic containing from 2 to 12 carbon atoms and at least one carbon to carbon double bond; “alkynyl” refers to a hydrocarbon radical straight, branched or cyclic containing from 2 to 12 carbon atoms and at least one carbon to carbon triple bond; “cycloalkyl” refers to saturated or partially unsaturated cyclic hydrocarbon rings containing from 3 to 15 carbon atoms, wherein the carbocyclic ring can be substituted at one or more substitutable ring positions by one or more groups independently selected from alkyl, alkoxy, nitro, monoalkylamino, dialkylamino, cyano, halo, haloalkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkyl amido, alkoxyalkyl, alkoxycarbonyl, alkylcarbonlyoxy, aryl, —CO “aryl” refers to monocyclic or bicyclic aromatic rings having from 6 to 14 atoms, wherein an aryl group contains at least one ring having at least 6 atoms, and wherein the term aryl includes both substituted and unsubstituted aryl groups, wherein aryl groups can optionally be substituted with one or more groups selected from halogen, alkyl, alkoxy, hydroxy, carboxy, carbamoyl, alkyloxycarbonyl, nitro, alkenyloxy, triflouromethyl, amino, cycloalkyl, aryl, heteroaryl, cyano, alkyl, S(O) “heteroaryl” refers to pyrrolyl, pyrazolyl, pyrazolinyl, imidazolyl, oxazolyl, diazolyl, isoxazolyl, thiazolyl, thiadiazolyl, isothiazolyl, furanyl, thienyl, oxadiazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, indolyl, benzothiazolyl, benzodioxolyl, benzoxaxolyl, benzothienyl, quinolinyl, tetrahydroisoquinolinyl, isoquinolinyl, benzimidazolyl, benzopyranyl, indolizinyl, benzofuranyl, chromonyl, coumarinyl, benzopyranyl, cinnolinyl, quinoxalinyl, indazolyl, pyrrolopyridyl, furopyridinyl, dihydroisoindolyl, tetrahydroquinolinyl, carbazolyl, benzidolyl, phenanthrollinyl, acridinyl, phenanthridinyl, or xanthenyl; wherein the heteroaryl can optionally contain one, two or three substituents selected from the group consisting of halo, alkyl, substituted alkyl, alkenyl, alkynyl, aryl, nitro, cyano, hydroxy, alkoxy, thioalkyl, —CO “heterocyclic ring” refers to imidazolinyl, thiazolinyl, imidazolindinyl, pyrrolyl, pyrrolinyl, pyranyl, pyrazinyl, piperidyl, morpholinyl, or triazolyl; wherein the heterocyclic ring can be optionally substituted by one or more groups independently selected from alkyl, alkoxy, nitro, monoalkylamino, dialkylamino, cyano, halo, haloalkyl, alkylcarbonyl, —C(═O)H, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkyl amido, alkoxyalkyl, alkoxycarbonyl, alkylcarbonyloxy and aryl; and “halogen” refers to chlorine, bromine, fluorine or iodine.