Patent ID: 7943172
Filing Date: 2011-05-17
Classification: A61K,A61P

Abstract:
1. A process for the production of a film-coated tablet, said process comprising: dry granulating an active ingredient consisting of imatinib monomethanesulfonate in alpha crystalline form and at least one compound acting as a filler-binder to obtain a starting material; compressing or compacting the dry granulated starting material to produce a tablet core; and coating said tablet core to form a film-coated tablet; wherein at least 80% the active ingredient has a mean particle size distribution in the range from 0.01 mm to 1.0 mm; wherein said dry granulating is carried out in a compactor at pressures in the range from 10 to 300 bar; and wherein the resulting tablet cores contain the active ingredient in a proportion of 25% by weight to 80% by weight, based on the total weight of the tablet cores.