Patent ID: 7196109
Filing Date: 2007-03-27
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a disease selected from the group consisting of: neurodegenerative diseases selected from the group consisting of cranial and spinal traumas and peripheral neuropathies; metabolic diseases; type II diabetes, essential hypertension; atherosclerotic cardiovascular diseases; polycystic ovarie syndrome; syndrome X; immunodeficiency; Parkinson's disease; frontoparietal dementia; corticobasal degeneration and Picks disease comprising administering to a subject in need thereof, an effective amount of a compound of formula (I); wherein R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroaryl fused to a (1–10C) cycloalkyl, heterocycle, heterocycloalkyl, cyoloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, CSNR1R2, COOR1, SO R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH R1, R2, R8, R9, R10 and R11 are, independently of one another, a hydrogen, (1–6C)alkyl, aryl, alkenyl, alkynyl, heteroaryl, themselves optionally being substituted by 1 or more substituents chosen from halogen, (1–6C)alkyl, (1–6C)alkoxy, CN, NO R1 and R2 or R8 and R9 or R10 and R11 can form a 5- or 6-membered ring which may or may not have a heteroatom, such as O, S or N; and, when R3 is a 6-membered nitrogenous heteroaryl or a thiazolyl or an imidazalyl or art oxazoly, then at least one of the R5 and R6 groups is an aryl which is optionally substituted by 1 or more substituents selected from halogen, CN, NO its racemates, enantiomiers or diastereoisomers and their mixtures, its tautomers and its pharmaceutically acceptable salts.