Patent ID: 9108928
Filing Date: 2015-08-18
Classification: A61K,A61P,C07D

Abstract:
1. A method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, comprising: reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide: wherein, in formula [1], each R independently represents a C reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; and reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, wherein the salt is an organic acid salt and the acidic solvent is a mineral acid solvent.