Patent ID: 8921537
Filing Date: 2014-12-30
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A polynucleotide encoding an anti-vascular endothelial growth factor (VEGF) antibody, wherein the antibody comprises six HVRs: (i) an HVR-L1 comprising the amino acid sequence of X (ii) an HVR-L2 comprising the amino acid sequence of DASSLA (SEQ ID NO:6); (iii) an HVR-L3 comprising the amino acid sequence of SYKSPL (SEQ ID NO:7); (iv) an HVR-H1 comprising the amino acid sequence of SISGSWIF (SEQ ID NO:1); (v) an HVR-H2 comprising the amino acid sequence of GAIWPFGGYTH (SEQ ID NO:2); and (vi) an HVR-H3 comprising the amino acid sequence of RWGHSTSPWAMDY (SEQ ID NO:3).