Patent ID: 6887875
Filing Date: 2005-05-03
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: R is oxygen or absent; Z Z Ar phenyl which is mono-, di-, or tri-substituted with R 1-naphthyl, 2-naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyrimidinyl, thienyl, thiazolyl, pyrazolyl, imidazolyl, tetrazolyl, oxazolyl, isoxazolyl, pyrrolyl, furanyl, and triazolyl, each of which is optionally mono-, di-, or tri-substituted with R Ar R with the proviso that at least one of R R R R X is independently selected at each occurrence from the group consisting of —CH Y and Z are independently selected at each occurrence from: 3- to 7-membered carbocyclic or heterocyclic groups, which are saturated, partially unsaturated, or aromatic, which may be further substituted with one or more substituents independently selected from halogen, oxo, hydroxy, amino, cyano, C n is independently selected at each occurrence from 0, 1, and 2.