Patent ID: 6472436
Filing Date: 2002-10-29
Classification: A61K,A61P,G01N,Y10S

Abstract:
A method of blocking amyloid toxicity in cells selected from the group consisting of nerve cells, glial cells, pancreatic cells, islets of Langerhans cells, endothelial cells, and endocrinic cells, said method comprising contacting said cells with an effective amount of at least one polycyclic compound selected from biphenyl compounds of Structure I, wherein said structures are: or enantiomers, diastereomeric isomers or mixtures of any two or more thereof, or pharmaceutically acceptable salts thereof, wherein:L is C1-C12 alkylene, substituted alkylene, cycloalkylene, substituted cycloalkylene or substituted lactone radical; S, T, U and V are independently OH, halogen, alkyl or substituted alkyl, each X is independently H, OH, SH or NH2; Xâ€² is H, SH, NH2 or OR, wherein R is H or lower alkyl, alkenyl, or alkynyl; Yâ€² is H, OH, SH, or NH2; and Z is H, OH, SH or NH2; provided, however, that at least one of Z and Yâ€² is H, or Z is absent when ring 3 is attached at the 3-position of ring 2.