Patent ID: 6312960
Filing Date: 2001-11-06
Classification: B01J,B01L,C40B,G01N,Y10S,Y10T

Abstract:
A method for preparing a reaction substrate for use as an assay device, comprising a step of parallel printing an array of biosites on said reaction substrate, wherein each biosite comprises a single type of capture probe bound to said reaction substrate, and wherein the array of biosites is deposited on the reaction substrate by a capillary bundle printer device, wherein the capillary bundle device comprises:a plurality of bundled capillary tubes, each tube having a proximal end and a distal end;an attachment site for holding the bundled capillary tubes at a point spaced from the distal ends of the capillary tubes;an array template for slidably holding each capillary tube near its distal end, and for allowing the distal end of each capillary tube to move with respect to the attachment site;at least one manifold for positioning the proximal end of each capillary tube within a corresponding supply chamber, wherein each supply chamber is capable of supplying a liquid reagent to at least one corresponding capillary tube; anda positioning device for precisely positioning the array template and the bundled capillary tubes with respect to the reaction substrate and depositing liquid reagents from the distal end of the capillary tubes onto the reaction substrates as biosites.