Patent ID: 6143719
Filing Date: 2000-11-07
Classification: A61K,A61P,C07K

Abstract:
A method of inhibiting thrombin-induced cell activation mediated by a thrombin receptor by inhibiting cleavage of the thrombin receptor on said cells comprising administering to an individual in need of such treatment an effective amount of a peptide, wherein said peptide has an amino acid sequence of the formula:X.sub.1 -Arg-Pro-Pro-Gly-X.sub.2wherein:X.sub.1 is zero amino acids or the segment Gly-Met-Ile-Ser-Leu-Met-Lys (SEQ ID NO:23), or an N-terminal truncation fragment of said segment; andX.sub.2 is zero amino acids or the segment Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-lle (SEQ ID NO:24), or a C-terminal truncation fragment of said segment;provided that the peptide is not native bradykinin.