Patent ID: 6627186
Filing Date: 2003-09-30
Classification: A61K,A61P,C07K

Abstract:
A non-naturally occurring GPA protein comprising at least five amino acid substitutions as compared to hG-CSF protein, wherein at least five of said substitutions are selected from the amino acid residues at positions selected from 14, 17, 20, 21, 24, 27, 28, 31, 32, 34, 35, 38, 78, 79, 85, 89, 91, 92, 99, 102, 103, 107, 109, 110, 113, 116, 120, 145, 146, 147, 148, 151, 153, 155, 156, 157, 160, 161, 163, 164, 167, 168 and 170.