Patent ID: 8067211
Filing Date: 2011-11-29
Classification: C12N,C12P

Abstract:
1. A isolated DNA encoding a modified polypeptide having glutamine synthetase 2 activity, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 1, wherein the modification is the substitution of glutamic acid at position 64 from the N-terminal of SEQ ID NO: 1 (corresponding to codon or nucleotides 190-192 of SEQ ID NO: 2) with an amino acid other than glutamic acid and further comprising deletion, substitution or addition of 1-20 amino acids in the sequence of SEQ ID NO: 1, wherein said DNA when expressed in Coryneform bacterium as a host cell results in increased L-glutamine production as compared unmodified wild type Coryneform bacterium.