Patent ID: 6645937
Filing Date: 2003-11-11
Classification: A61K,A61P,C07K

Abstract:
A method for promoting the survival of a mesencephalic neuronal cell comprising administering to the cell a persephin polypeptide; said polypeptide comprising an amino acid sequence that contains amino acids at positions indicated in parentheses:Cys (1), Leu (3), Val (10), Leu (13), Gly (14), Leu (15), Gly (16), Tyr (17), Glu (21), Phe (25), Arg (26), Tyr (27), Cys (28), Gly (30), Cys (32), Leu (44), Leu (47), Cys (58), Cys (59), Pro (61), Asp (66), Phe (69), Leu (70), Asp (71), Ser (83), Ala (84), Cys (87), and Cys (89), said positions being identified by alignment with a mouse persephin sequence as set forth in SEQ ID NO:79 or a rat persephin sequence as set forth in SEQ ID NO:82; wherein said persephin amino acid sequence has at least 96% sequence identity with SEQ ID NO:79 or SEQ ID NO:82 and wherein said persephin polypeptide promotes survival of mesencephalic neuronal cells.