Patent ID: 7121999
Filing Date: 2006-10-17
Classification: A61L,B29C

Abstract:
1. The method of preparing a prosthesis having two or more superimposed, bonded layers of processed tissue matrix, comprising: (a) layering two or more sheets of hydrated processed tissue matrix; (b) dehydrating said layers to adhere the layers together; (c) crosslinking said layers with a crosslinking agent to bond the layers together; and, (d) rinsing said layers to remove the crosslinking agent; wherein said thus formed prosthesis when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient's living cells, wherein the processed tissue matrix is prepared by; (e) mechanically cleaning the layers of tissue matrix and (f) chemically cleaning the layers of tissue matrix, wherein chemically cleaning the layers of tissue matrix comprises: (g) contacting the tissue matrix with a chelating agent under alkaline conditions; (h) contacting the tissue matrix with an acid containing a salt; (i) contacting the tissue matrix with a buffered salt solution; and (j) rinsing the tissue matrix.