Patent ID: 9161520
Filing Date: 2015-10-20
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A transgenic mouse having germ and somatic cells whose genome comprises a transgene comprising a DNA construct comprising: (i) a cDNA sequence coding for a truncated tau protein, wherein the truncated tau protein is that encoded by the cDNA sequence selected from SEQ ID NOS 1-14; and (ii) a tissue-specific promoter, wherein the cDNA sequence is operably linked to a the tissue-specific promoter, wherein the tissue-specific promoter is functional in mouse brain cells; and wherein neurofibrillary (NF) pathology associated with Alzheimer's disease occurs in the resulting transgenic mouse expressing the transgenic truncated tau protein in the brain when compared to a non-transgenic mouse counterpart.