Patent ID: 9138445
Filing Date: 2015-09-22
Classification: A61K,A61L

Abstract:
1. A dried extracellular matrix graft construct from submucosa tissue, comprising: a sheet-form remodelable extracellular matrix substrate layer and an adherent fibrillar mass, said adherent fibrillar mass received directly against said remodelable extracellular matrix substrate layer, the adherent fibrillar mass comprising (i) solubilized extracellular matrix components prepared by digesting an extracellular matrix starting material from submucosa tissue with a digestive agent and (ii) an inactivated form of the digestive agent; wherein the native crosslinks present in the extracellular matrix have been disrupted, wherein said extracellular matrix components of said adherent fibrillar mass include collagen, growth factors, glycosaminoglycans, glycoproteins, and proteoglycans, retained from the source of submucosa tissue; wherein said adherent fibrillar mass is in the form of a dried layer having a thickness in the range of 10 microns to 10 millimeters; wherein said dried adherent fibrillar mass layer has a density less than that of said underlying base sheet-form remodelable extracellular matrix substrate layer; wherein said components are available in the dried layer for burst release when the dried extracellular matrix graft construct is applied to a wound site, and wherein said sheet-form remodelable extracellular matrix substrate layer retains collagen, growth factors, glycosaminoglycans, glycoproteins, and proteoglycans from the submucosa tissue.