Patent ID: 6306579
Filing Date: 2001-10-23
Classification: A61K,A61P,C07K,C12N,G01N,Y10S

Abstract:
Method for determining a hepatitis C virus specific antibody in a sample, comprising:incubating said sample with at least one peptide derived from a hepatitis C virus protein NS3 region wherein said at least one peptide has higher immunological activity with said hepatitis C virus specific antibody than a polypeptide consisting of an amino acid sequence from an NS3 protein region of a naturally occurring hepatitis C virus, wherein said at least one peptide has at least one covalently modified cysteine residue or at least one cysteine residue has been replaced by a different amino acid to form a peptide having a sequence not found in any HCV isolate, and determining binding of said antibody to said at least one peptide.