Patent ID: 7919458
Filing Date: 2011-04-05
Classification: A61K,A61P,C12Q,C12Y,G01N

Abstract:
1. A method of inhibiting or reducing the proliferation of prostate cancer cells that express a sPLA 2 -IIA polypeptide comprising the amino acid sequence of SEQ ID NO: 3 in a human subject who has been subjected to androgen ablation therapy, the method comprising administering to the subject a selective inhibitor of the enzyme activity of the polypeptide, wherein the inhibitor inhibits the ability of the polypeptide to catalyse the hydrolysis of membrane phospholipids at the sn-2 position to release fatty acids and lysophospholipids, wherein the inhibitor inhibits the sPLA 2 -IIA-mediated proliferation of prostate cancer cells, and wherein the inhibitor is a cyclic peptide of the following formula: A1 is F or Y or W or 2Nap A2 is L or I A3 is S or T A4 is F or Y or W or 2Nap, and A5 is R or K.