Patent ID: 6759404
Filing Date: 2004-07-06
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of Formula (I): or a stereoisomer, pharmaceutically acceptable salt thereof, wherein:L is â€”NR26C(&boxH;O)â€”, â€”C(&boxH;O)NR26â€”, â€”NR26C(&boxH;O)Oâ€”, â€”OC(&boxH;O)NR26, or â€”NR26C(&boxH;O)NR26â€”; R3 is â€”(CR7R7a)nâ€”R4, â€”(CR7R7a)lâ€”Sâ€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”Oâ€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”N(R7b)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”S(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”S(&boxH;O)2â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”C(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”N(R7b)C(&boxH;O)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”C(&boxH;O)N(R7b)â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)lâ€”N(R7b)S(&boxH;O)2â€”(CR7R7a)mâ€”R4, or â€”(CR7R7a)lâ€”S(&boxH;O)2N(R7b)â€”(CR7R7a)mâ€”R4; n is 0, 1, 2, or 3; m is 0, 1, 2, or 3; l is 1, 2, or 3; Ring C is a 3 to 8 membered carbocycle, wherein the carbocycle is saturated or partially saturated; optionally, the carbocycle contains a heteroatom selected from â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, and â€”N(R20)â€”; and wherein the carbocycle is substituted with 0-4 R21; R4 is H, OH, OR14a, C1-C8 alkyl substituted with 0-3 R4a, C2-C8 alkenyl substituted with 0-3 R4a, C2-C8 alkynyl substituted with 0-3 R4a, C3-C10 carbocycle substituted with 0-3 R4b, C6-C10 aryl substituted with 0-3 R4b, or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R4b; R4a, at each occurrence, is independently selected from H, OH, F, Cl, Br, I, NR15R16, CF3, C3-C10 carbocycle substituted with 0-3 R4b, C6-C10 aryl substituted with 0-3 R4b, and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R4b; R4b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R6 is H; C1-C6 alkyl substituted with 0-3 R6a; C3-C10 carbocycle substituted with 0-3 R6b; or C6-C10 aryl substituted with 0-3 R6b; R6a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, aryl and CF3; R6b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy; R7, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, CF3, C1-C4 alkyl, phenyl substituted with 0-5 R7c; R7a, at each occurrence, is independently selected from H, Cl, F, Br, I, CN, CF3, and C1-C4 alkyl; R7b is independently selected from H and C1-C4 alkyl; R7c, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, CF3, C1-C4 alkoxy, and C1-C4 alkyl; Ring B is a seven membered lactam, wherein the lactam is saturated, partially saturated or unsaturated; wherein each additional lactam carbon is substituted with 0-2 R11; and, optionally, the lactam contains an additional heteroatom selected from â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”N&boxH;, â€”NHâ€”, and â€”N(R10)â€”; R10 is H, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, S(&boxH;O)2R17; C1-C6 alkyl optionally substituted with 0-3 R10a; C6-C10 aryl substituted with 0-4 R10b; C3-C10 carbocycle substituted with 0-3 R10b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R10b; R10a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3, aryl substituted with 0-4 R10b; C3-C10 carbocycle substituted with 0-3 R10b, and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R10b; R10b, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R11, at each occurrence, is independently selected from H, C1-C4 alkoxy, Cl, F, Br, I, &boxH;O, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl optionally substituted with 0-3 R11a; C6-C10 aryl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3; phenyl substituted with 0-3 R11b; C3-C6 cycloalkyl substituted with 0-3 R11b; and 5 to 6 membered heterocycle containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 6 membered heterocycle is substituted with 0-3 R11b; R11b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; additionally, two R11 substituents on adjacent atoms may be combined to form a 5 to 6 membered heteroaryl fused radical, wherein said 5 to 6 membered heteroaryl fused radical comprises 1 or 2 heteroatoms selected from N, O, and S; wherein said 5 to 6 membered heteroaryl fused radical is substituted with 0-3 R13; additionally, two R11 substituents on the same or adjacent carbon atoms may be combined to form a C3-C6 carbocycle substituted with 0-3 R13; additionally, two R11 substituents on adjacent atoms may be combined to form a benzo fused radical; wherein said benzo fused radical is substituted with 0-4 R13; W is â€”(CR8R8a)pâ€”; p is 0, 1, 2, 3, or 4; R8 and R8a, at each occurrence, are independently selected from H, F, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl and C3-C8 cycloalkyl; X is a bond; C6-C10 aryl substituted with 0-3 RXb; C3-C10 carbocycle substituted with 0-3 RXb; or 5 to 10 membered heterocycle substituted with 0-2 RXb; RXb, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; Y is a bond or â€”(CR9R9a)tâ€”Vâ€”(CR9R9a)uâ€”; t is 0, 1, 2, or 3; u is 0, 1, 2, or 3; R9 and R9a, at each occurrence, are independently selected from H, F, C1-C6 alkyl and C3-C8 cycloalkyl; V is a bond, â€”C(&boxH;O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”N(R19)â€”, â€”C(&boxH;O)NR19bâ€”, â€”NR19bC(&boxH;O)â€”, â€”NR19bS(&boxH;O)2â€”, â€”S(&boxH;O)2NR19bâ€”, â€”NR19bS(&boxH;O)â€”, S(&boxH;O)NR19bâ€”, â€”C(&boxH;O)Oâ€”, or â€”OC(&boxH;O)â€”; Z is H; C1-C8 alkyl substituted with 1-3 R12; C2-C4 alkenyl substituted with 1-3 R12; C2-C4 alkynyl substituted with 1-3 R12; C1-C8 alkyl substituted with 0-3 R12a; C2-C4 alkenyl substituted with 0-3 R12a; C2-C4 alkynyl substituted with 0-3 R12a; C6-C10 aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12, at each occurrence, is independently selected from C6-C10 aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12a, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, â€”C(&boxH;O)NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R12b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R13, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, and CF3; R14 is H, phenyl substituted with 0-4 R14b, benzyl substituted with 0-4 R14b, C1-C6 alkyl, C2-C6 alkoxyalkyl, or C3-C6 cycloalkyl; R14a is H, C6-C10 aryl, benzyl, heterocycle, or C1-C4 alkyl; R14b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R15, at each occurrence, is independently selected from H, C1-C6 alkyl, aryl-(C1-C6 alkyl)- wherein the aryl is substituted with 0-4 R15b, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R15b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R16, at each occurrence, is independently selected from H, C1-C6 alkyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R17 is H, C1-C6 alkyl, C2-C6 alkoxyalkyl, aryl substituted by 0-4 R17a, or â€”CH2-aryl substituted by 0-4 R17a; R17a is H, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, â€”OH, F, Cl, Br, I, CF3, OCF3, SCH3, S(O)CH3, SO2CH3, â€”NH2, â€”N(CH3)2, or C1-C4 haloalkyl; R18, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R19, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R20 is H, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, S(&boxH;O)2R17; C1-C6 alkyl optionally substituted with 0-2 R20a; C6-C10 aryl substituted with 0-4 R20b; C3-C10 carbocycle substituted with 0-3 R20b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R20b; R20a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, F, &boxH;O, CN, NO2, NR15R16, CF3, aryl substituted with 0-4 R20b, and heterocycle substituted with 0-4 R20b; R20b, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R21, at each occurrence, is independently selected from H, C1-C4 alkoxy, Cl, F, Br, I, &boxH;O, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl optionally substituted with 0-3 R21a; C6-C10 aryl substituted with 0-3 R21b; C3-C10 carbocycle substituted with 0-3 R21b; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R21b; R21a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3; phenyl substituted with 0-3 R21b; C3-C6 cycloalkyl substituted with 0-3 R21b; and 5 to 6 membered heterocycle containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 6 membered heterocycle is substituted with 0-3 R21b; R21b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; additionally, two R21 substituents on adjacent atoms may be combined to form a 5 to 6 membered heteroaryl fused radical, wherein said 5 to 6 membered heteroaryl fused radical comprises 1 or 2 heteroatoms selected from N, O, and S; wherein said 5 to 6 membered heteroaryl fused radical is substituted with 0-3 R23; additionally, two R21 substituents on the same or adjacent carbon atoms may be combined to form a C3-C6 carbocycle substituted with 0-3 R23; additionally, two R21 substituents on adjacent atoms may be combined to form a benzo fused radical; wherein said benzo fused radical is substituted with 0-4 R23; R23, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, and CF3; R26 is H; C1-C6 alkyl substituted with 0-3 R26a; C3-C10 carbocycle substituted with 0-3 R26b; or C6-C10 aryl substituted with 0-3 R26b; R26a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O , CN, NO2, NR15R16, aryl and CF3; and R26b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy.