Patent ID: 8895057
Filing Date: 2014-11-25
Classification: A61K,A61P

Abstract:
1. A method for effecting weight loss in a patient having a body mass index of at least 25 kg/m 2 , comprising administering an escalating unit dosage form comprising, (a) a first dosage form, comprising, wherein the first dosage form is administered to the subject daily for at least 2 weeks; and (b) a second dosage form, comprising, wherein the topiramate formulated for controlled release reaches maximum plasma concentration (Cmax) at about 6 to about 10 hours (Tmax) after administration and exhibits a lower Cmax, than non-controlled release topiramate, without decreasing total drug exposure defined by the area under the concentration-time curve (AUC), and wherein the second dosage form is administered to the subject daily for at least 2 years, thereby effecting weight loss.