Patent ID: 8710224
Filing Date: 2014-04-29
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) wherein Q is a secondary or tertiary amine of the formula —N(R and wherein each chain or ring is independently optionally substituted by one or two of fluorine, hydroxy, hydroxymethyl, methyl, methoxy, ethyl, ethoxy, propenyl, carboxy, methoxycarbonyl, ethoxycarbonyl, cyano, or methylsulfonyl each selected independently; L taken together with the nitrogen atom of the amine Q and with R W is piperazine, unsubstituted or monosubstituted by hydroxy, ═O or halogen; X is O; Z is NR P is phenyl or naphthyl, or an up to 10 ring membered heteroaryl group comprising 1 or 2 heteroatoms independently selected from N, O or S such as thiophene, isoxazole, benzisoxazole, thiazole, thiadiazole, pyridine, pyrazole, benzthiazole; all of which are optionally substituted by 1, 2 or 3 substituents each independently selected from chlorine, fluorine, bromine, methyl, ethyl, cyano, trifluoromethyl, methoxy, trifluoromethoxy, phenyl, phenoxy, benzoxy, thiomethyl, thioethyl, trifluoromethylthio, methoxycarbonyl, ethoxycarbonyl, and NO or a pharmaceutically acceptable salt or solvate thereof.