Patent ID: 6623981
Filing Date: 2003-09-23
Classification: C07K,G01N,Y10S

Abstract:
A method for detecting the formation or increase of drug-dependent antibodies (DDABs) that bind to an integrin, an integrin-associated protein or a complex thereof, comprising:(a) assaying a biological sample from a subject for antibodies which recognize an integrin bound with an integrin antagonist/agonist by the steps comprising incubating the biological sample with a source of antibodies and detecting the antibodies that bind; (b) administering to the subject an integrin antagonist/agonist; (c) assaying a second biological sample from the subject for antibodies which recognize said integrin bound with said integrin antagonist/agonist by the steps comprising incubating the second biological sample with a source of antibodies and detecting the antibodies that bind; and (d) comparing the results of (a) with the results of (c).