Patent ID: 7375107
Filing Date: 2008-05-20
Classification: A61P,C07D

Abstract:
1. A compound represented by formula (I): wherein X is hydrogen, halogen, trifluoromethyl, lower alkyl, unsubstituted or substituted phenyl, lower alkyl-thio, phenyl-lower alkyl-thio, lower alkyl-sulfonyl, or phenyl-lower alkyl-sulfonyl; Y is hydrogen, hydroxyl, mercapto, lower alkoxy, lower alkyl-thio, halogen, lower alkyl, unsubstituted or substituted mononuclear aryl, or —N(R R each R R each R each o is, independently, an integer from 0 to 17; each p is an integer from 0 to 17; with the proviso that the sum of o and p in each contiguous chain is from 1 to 17; each x is, independently, —O—, —NR each R —(CH 2 ) n —NR 12 R 12 , —O—(CH 2 ) m —NR 12 R 12 , —O—(CH 2 ) n —NR 12 R 12 , —O—(CH 2 ) m -(Z) g R 12 , —(CH 2 ) n NR 11 R 11 , —O—(CH 2 ) m NR 11 R 11 , —(CH 2 ) n —N ⊕ —(R 11 ) 3 , —O—(CH 2 ) m —N ⊕ —(R 11 ) 3 , —(CH 2 ) n -(Z) g —(CH 2 ) m —NR 10 R 10 , —O—(CH 2 ) m -(Z) g -(CH 2 ) m —NR 10 R 10 , —(CH 2 CH 2 O) m —CH 2 CH 2 NR 12 R 12 , —O—(CH 2 CH 2 O) m —CH 2 CH 2 NR 12 R 12 , —(CH 2 ) n —(C═O)NR 12 R 12 , —O—(CH 2 ) m —(C═O)NR 12 R 12 , —O—(CH 2 ) m —(CHOR 8 ) m CH 2 NR 10 -(Z) g -R 10 , —(CH 2 ) n —(CHOR 8 ) m CH 2 —NR 10 -(Z) g -R 10 , —(CH 2 ) n NR 10 —O(CH 2 ) m (CHOR 8 ) n CH 2 NR 10 -(Z) g -R 10 , —O(CH 2 ) m —NR 10 —(CH 2 ) m —(CHOR 8 ) n CH 2 NR 10 -(Z) g -R 10 , -(Het)-(CH 2 ) m —OR 8 , -(Het)-(CH 2 ) m —NR 7 R 10 , -(Het)-(CH 2 ) m (CHOR 8 )(CHOR 8 ) n —CH 2 OR 8 , -(Het)-(CH 2 CH 2 O) m —R 8 , -(Het)-(CH 2 CH 2 O) m —CH 2 CH 2 NR 7 R 10 , -(Het)-(CH 2 ) m —C(═O)NR 7 R 10 , -(Het)-(CH 2 ) m -(Z) g -R 7 , -(Het)-(CH 2 ) m —NR 10 —CH 2 (CHOR 8 )(CHOR 8 ) n —CH 2 OR 8 , -(Het)-(CH 2 ) m —CO 2 R 7 , -(Het)-(CH 2 ) n —NR 12 R 12 , -(Het)-(CH 2 ) n —NR 12 R 12 , -(Het)-(CH 2 ) m -(Z) g R 2 , -(Het)-(CH 2 ) m NR 11 R 11 , -(Het)-(CH 2 ) m —N ⊕ —(R 11 ) 3 , -(Het)-(CH 2 ) m -(Z) g -(CH 2 ) m —NR 10 R 10 , -(Het)-(CH 2 CH 2 O) m —CH 2 CH 2 NR 12 R 12 , -(Het)-(CH 2 ) m —(C═O)NR 12 R 12 , -(Het)-(CH 2 ) m —(CHOR 8 ) m CH 2 NR 10 -(Z) g -R 10 , -(Het)-(CH 2 ) m —NR 10 —(CH 2 ) m —(CHOR 8 ) n CH 2 NR 10 -(Z) g -R 10 , —(CH 2 ) n (CHOR 8 )(CHOR 8 ) 1-7 —CH 2 OR 8 , with the proviso that at least two —CH 2 OR 8 are located 1,2- or 1,3- to each other and the R 8 groups are joined to form a cyclic mono- or di-substituted 1,3-dioxane or 1,3-dioxolane, —O—(CH 2 ) m (CHOR 8 )(CHOR 8 ) n —CH 2 OR 8 , with the proviso that at least two —CH 2 OR 8 are located 1,2-1,3- to each other and the R 8 groups are joined to form a cyclic mono- or di-substituted 1,3-dioxane or 1,3-dioxolane, —(CH 2 ) n —NR 10 —CH 2 (CHOR 8 )(CHOR 8 ) 1-7 —CH 2 OR 8 , with the proviso that at least two —CH 2 OR 8 are located 1,2- or 1,3- to each other and the R 8 groups are joined to form a cyclic mono- or di-substituted 1,3-dioxane or 1,3-dioxolane, —O—(CH 2 ) m —NR 10 —CH 2 (CHOR 8 )(CHOR 8 ) n —CH 2 OR 8 , with the proviso that at least two —CH 2 OR 8 are located 1,2- or 1,3- to each other and the R 8 groups are joined to form a cyclic mono- or di-substituted 1,3-dioxane or 1,3-dioxolane, -Link-(CH 2 ) n -CAP, -Link-(CH 2 ) n (CHOR 8 )(CHOR 8 ) n -CAP, -Link-(CH 2 CH 2 O) m —CH 2 -CAP, -Link-(CH 2 CH 2 O) m —CH 2 CH 2 -CAP, -Link-(CH 2 ) n -(Z) g -CAP, -Link-(CH 2 ) n (Z) g -(CH 2 ) m -CAP, -Link-(CH 2 ) n —NR 13 —CH 2 (CHOR 8 )(CHOR 8 ) n -CAP, -Link-(CH 2 ) n —(CHOR 8 ) m CH 2 —NR 3 -(Z) g -CAP, -Link-(CH 2 ) n —NR 13 —(CH 2 ) m (CHOR 8 ) n CH 2 NR 13 -(Z) 8 -CAP, -Link-(CH 2 ) m -(Z) g -(CH 2 ) m -CAP, -Link-NH—C(═O)—NH—(CH 2 ) m -CAP, -Link-(CH 2 ) m —C(═O)NR 13 —(CH 2 ) m —C(═O)NR 10 R 10 , -Link-(CH 2 ) m —C(═O)NR 13 —(CH 2 ) m -CAP, -Link-(CH 2 ) m —C(═O)NR 11 R 11 , -Link-(CH 2 ) m —C(═O)NR 12 R 12 , -Link-(CH 2 ) n -(Z) g -(CH 2 ) m -(Z) g -CAP, or -Link-Z g -(CH 2 ) m -Het-(CH 2 ) m -CAP; each Link is, independently, —O—, —(CH each CAP is, independently, thiazolidinedione, oxazolidinedione, heteroaryl-C(═O)NR each Ar is, independently, phenyl, substituted phenyl, wherein the substituents of the substituted phenyl are 1-3 substituents independently selected from the group consisting of OH, OCH each W is independently, thiazolidinedione, oxazolidinedione, heteroaryl-C(═O)NR each R each R each R each R each R each Z is, independently, —CHOH, —C(═O), —(CH each R each R each R each Het is independently, —NR each g is, independently, an integer from 1 to 6; each m is, independently, an integer from 1 to 7; each n is, independently, an integer from 0 to 7; with the proviso that, when any two —CH or a pharmaceutically acceptable salt thereof, and inclusive of all enantiomers, diastereomers, and racemic mixtures thereof.