Patent ID: 9107804
Filing Date: 2015-08-18
Classification: A61J,A61K

Abstract:
1. A pellet which is adapted for use as a core for a pharmaceutical dosage form, said pellet comprising: an inner zone which is located in a center of the pellet, the inner zone being homogeneous and comprising a biologically active agent; and an outer zone comprising: a substantially dry, free-flowing inert powder; a swellable matrix forming polymer; and and a non-swellable matrix forming polymer; wherein the powder includes at least one component from the group consisting of microcrystalline cellulose, dicalcium phosphate, calcium sulfate, talc, an alkali metal stearate, silicon dioxide, and calcium carbonate; wherein the swellable matrix forming polymer includes at least one component selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, and carboxypolymethylene; wherein the non-swellable matrix forming polymer includes at least one component selected from the group consisting of acrylic/methacrylic polymers and ethyl cellulose; wherein the outer zone is formed on the inner zone without first drying the inner zone; and wherein the pellet has a cross section which is visually homogeneous such that there is no visible distinction between the inner zone and the outer zone when viewed by a scanning electron microscope.