Patent ID: 6593306
Filing Date: 2003-07-15
Classification: A61K,C07H

Abstract:
A method of reducing the proliferative capacity of a cell comprising contacting said cell with a compound or a salt thereof or a stereoisomer of said compound that has the formula of (A) or (B): where R1 is independently H, alkyl, arylalkyl, or aryl; Z is sulfur or oxygen; Y is independently H, alkyl, arylalkyl, aryl or acyclic or cyclic glycosyl groups represented by the formulae: where R2, R3, R4, R5, are independently H, OH, halogen, amino or azido; provided that R3 and R5 may be unsubstituted when there is a double bond between the carbons bonded to R2 and R4; R6 is independently H, alkylcarbonyl or arylcarbonyl; R7 is independently OH, triphosphate, PO(OR8)2, OP(O)(OR8)2, OP(O)(OR9)(R10); R8 is independently H, alkyl, aryl, or CH2C(O) alkyl; R9 is independently H, alkyl, or aryl, and R10 is independently an N-linked amino acid alkyl ester; N-linked amino acid arylalkyl ester, or N-linked amino acid aryl ester; V is independently sulfur, oxygen or methylene and n is 1-2.