Patent ID: 6241995
Filing Date: 2001-06-05
Classification: A61K,C07H

Abstract:
A vaccine composition comprising:(a) an adjuvant composition comprising a Polygala senega saponin extract comprising at least one P. senega saponin capable of potentiating an immunological response, wherein said P. senega saponin extract is obtained from a P. senega L. plant;(b) a selected vaccine antigen; and(c) a pharmaceutically acceptable vehicle,and further wherein said P. senega saponin extract comprises at least one saponin having the general structure: ##STR2##where R.sup.1 is hydrogen; R.sup.2 is selected from the group consisting of hydrogen, the E isomer of 4-methoxycinnamoyl, the Z isomer 4-methoxycinnamoyl, the E isomer of 3,4-dimethoxycinnamoyl, and the Z isomer of 3,4-dimethoxycinnamoyl; and R.sup.3 is selected from the group consisting of hydrogen and .beta.-D-apiofuranosyl.