Patent ID: 7531304
Filing Date: 2009-05-12
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for screening a compound which is capable of stimulating the activity of a Fibroblast Growth-Factor Receptor species 4 (FGFR-4) for the manufacture of a diagnostic or therapeutic agent comprising measuring the ability of said compound to (1) bind to said FGFR-4 species and (2) stimulate the tyrosine kinase activity of said FGFR-4 by binding thereto, wherein said FGFR-4 species is human FGFR-4 Gly388 or human FGFR-4 Arg388, and wherein said method is carried out as a cell-based assay using an FGFR-4 expressing said or overexpressing cell or as a cell-free assay using said FGFR-4 species protein.