Patent ID: 6326382
Filing Date: 2001-12-04
Classification: A61K,C07D

Abstract:
A compound of the formula ##STR57##whereinR.sup.1 and R.sup.2 are independently selected from hydrogen, (C.sub.1 -C.sub.6)alkoxy, benzyloxy, phenoxy, hydroxy, phenyl, benzyl, halo, nitro, cyano, COR.sup.5, --COOR.sup.5, --CONHR.sup.5, --NR.sup.5 R.sup.6, --NR.sup.5 COR.sup.6, --OCONR.sup.5 R.sup.6, --NHCOOR.sup.5, (C.sub.1 -C.sub.6)alkyl optionally substituted with from 1 to 3 fluorine atoms; SO.sub.p CH.sub.2 -phenyl or SO.sub.p (C.sub.1 -C.sub.6)alkyl, wherein p is 0, 1 or 2; pyridylmethyloxy, thienylmethyloxy; 2-oxazolyl, 2-thiazolyl and benzenesulfonamide; wherein the phenyl moieties of said phenoxy, benzyloxy, phenyl, benzyl and benzenesulfonamide groups, the pyridyl and thienyl moieties of said pyridylmethyloxy or thienylmethyloxy and the oxazolyl and thiazolyl moieties of said 2-oxaxolyl and 2-thiazolyl may optionally be substituted with 1 or 2 substituents independently selected from halo, (C.sub.1 -C.sub.4)alkyl, trifluoromethyl, (C.sub.1 -C.sub.4)alkoxy, cyano, nitro and hydroxy;or R.sup.1 and R.sup.2, when attached to adjacent carbon atoms, may form, together with the carbon atoms to which they are attached, a group of the formula ##STR58##wherein""a"" is 1 or 2,X is oxygen,Y is --(CH.sub.2).sub.m --, --CH.dbd.CH(CH.sub.2).sub.n --, --NR.sup.4 (CH.sub.2).sub.m --, or --O(CH.sub.2).sub.m -- wherein R.sup.4 is hydrogen or (C.sub.1 -C.sub.4)alkyl, n is an integer from 0 to 3 and m is an integer from 1 to 3;R.sup.5 and R.sup.6 are each independently selected from hydrogen, (C.sub.1 -C.sub.6)alkyl, phenyl and benzyl, wherein the phenyl moieties of said phenyl and benzyl may optionally be substituted with 1 or 2 substituents independently selected from fluoro, chloro, bromo, iodo, (C.sub.1 -C.sub.4) alkyl, trifluoromethyl, (C.sub.1 -C.sub.4) alkoxy, cyano, nitro and hydroxy; or NR.sup.5 R.sup.6 together form a 4 to 5 membered ring wherein one atom of the ring is nitrogen and the others are carbon, oxygen, nitrogen, or NR.sup.5 COR.sup.6 together form a 4 to 5 membered cyclic lactam ring;M is --CH--;L is phenyl, phenyl-(C.sub.1 -C.sub.6)alkyl, cinnamyl or pyridylmethyl, wherein the phenyl moieties of said phenyl and phenyl-(C.sub.1 -C.sub.6)alkyl may optionally be substituted with 1-3 substituents independently selected from (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.4)alkoxycarbonyl, (C.sub.1 -C.sub.4)alkylcarbonyl, --OCONR.sup.5 R.sup.6, --NHCOOR.sup.5 and halo; or L is a group of the formula ##STR59##whereinb is an integer from 1 to 4, R.sup.13 and R.sup.14 are independently selected from hydrogen, (C.sub.1 -C.sub.4) alkyl, halo and phenyl, E and F are independently selected from --CH-- and nitrogen, and G is oxygen, sulfur or NR.sup.4 wherein R.sup.4 is defined as above, with the proviso that when E and F are both nitrogen, one of R.sup.13 and R.sup.14 is absent; andR.sup.7 and R.sup.8 are independently selected from hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylcarbonyl and (C.sub.1 -C.sub.6)alkoxy, with the proviso that said (C.sub.1 -C.sub.6)alkoxy is not attached to a carbon that is adjacent to a nitrogen;or pharmaceutically acceptable salt of such compound.