Patent ID: 6790935
Filing Date: 2004-09-14
Classification: C07K

Abstract:
A compound which is obtained by replacing at least one amino acid of a naturally-occurring cyclosporin with an amino acid of formula I: in whichX denotes an oxygen or a sulfur; R denotes a hydrogen, or an alkyl group having between 1 and 6 carbon atoms; R1 and R2 denote, independently of each other, a hydrogen, an alkyl group, having between 1 and 6 carbons, which may be straight-chain or branched-chain, substituted or non-substituted, an alkylene group having between 1 and 6 carbon atoms, a substituted or non-substituted aryl group, a substituted or non-substituted heteroaryl group, or R1 and R2 each independently denotes a residue of water-soluble polymer, wherein said polymer is optionally bonded to the carbon bearing R1 and R2 via a spacer group.