Patent ID: 8105573
Filing Date: 2012-01-31
Classification: A61K,A61P,C07K

Abstract:
1. A modified interferon beta (IFN-β) cytokine, wherein said modified interferon beta cytokine differs from an unmodified IFN beta cytokine by two amino acid substitutions, wherein said unmodified interferon beta cytokine comprises the amino acid sequence of SEQ ID NO: 196, wherein said two amino acid substitutions are selected from the group consisting of: (a) substitution of the 5th and 10th positions in SEQ ID NO: 196 with asparagine and aspartic acid, respectively; (b) substitution of the 6th and 86th positions in SEQ ID NO: 196 with glutamic acid and glutamine, respectively; (c) substitution of the 5th and 36th positions in SEQ ID NO: 196 with aspartic acid and isoleucine, respectively; (d) substitution of the 5th and 108th positions in SEQ ID NO: 196 with glutamine and serine, respectively; (e) substitution of the 6th and 108th positions in SEQ ID NO: 196 with glutamic acid and serine, respectively; and (f) substitution of the 5th and 108th positions in SEQ ID NO: 196 with glutamic acid and serine, respectively; and wherein said two amino acid substitutions confer increased resistance to proteolysis over the unmodified IFN beta cytokine.