Patent ID: 8575110
Filing Date: 2013-11-05
Classification: A61K,C07K,Y02A

Abstract:
1. A peptidic nanoparticle consisting of an assembly of 10 or more peptides, in which each peptide is consisting of a continuous chain of a peptidic oligomerization domain D1, a linker segment L, and a peptidic oligomerization domain D2 of formula (I): wherein each D1 is a synthetic or natural peptide, and a plurality of D1 form at least one protein oligomer assembly (D1) each D2 is a synthetic or natural peptide, and a plurality of D2 form at least one protein oligomer assembly (D2) the peptidic nanoparticle contains: (a) one of m or n is 2 forming a dimer protein oligomer assembly, and the other of m or n is 5 forming a pentamer protein oligomer assembly; or (b) one of m or n is 3 forming a trimer protein oligomer assembly, and the other of m or n is 4 or 5 forming a tetramer or pentamer protein oligomer assembly, respectively; or (c) one of m or n is 4 forming a tetramer protein oligomer assembly, and the other of m or n is 5 forming a pentamer protein oligomer assembly; L is a short flexible linker segment, at least one D1 or D2 is a coiled-coil peptide sequence, and D1, D2 or L is optionally further substituted by a substituent selected from a targeting entity, drug and antigen.