Patent ID: 7598235
Filing Date: 2009-10-06
Classification: A61K,C07C,C07D,C07K

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: R X is Q G is —O— or —C(O)O—; Q at least one of t, u and v is 1; D is a pharmaceutically active chemical compound containing at least one carboxylic acid group and at least one moiety selected from the group consisting of a primary amino group, a secondary amino group or a hydroxyl group, with the provisos that D is not a GABA analog; L-Dopa, an L-aromatic amino acid decarboxylase inhibitor, a catechol O-methyl transferase inhibitor or derivatives thereof; a naturally occurring α-amino acid or an ester or carboxamide of a naturally occurring α-amino acid; a polypeptide derived from a linear oligopeptide containing at least 3 α-amino acids; an oligonucleotide; a cyclophane derivative, a diethylenetriaminopentaacetate derivative, or paramagnetic ion chelates thereof; 5-de-O-methylsporaricin; a bis-(2-chloroethyl)amine containing nitrogen mustard; an HMG-CoA reductase inhibitor; a proline hydroxylase inhibitor; or a steroid containing the carbon substructures of the following formulae:  and Z is a substituted alkyl group containing a moiety which is negatively charged at physiological pH, which moiety is selected from the group consisting of —COOH, —SO