Patent ID: 7553623
Filing Date: 2009-06-30
Classification: C12Q,Y10S

Abstract:
1. An in vitro method of screening human subjects to assess their risk of developing cervical carcinoma, which method comprises screening the subject for expression of mRNA transcripts of the E6 gene of HPV types 16, 18, 31, 33 and/or 45 and sorting the subject into one of two categories of risk for development of cervical carcinoma based on expression of E6 mRNA, wherein individuals positive for expression of E6 mRNA from at least one of HPV types 16, 18, 31, 33 or 45, said positive expression being the presence of more than 50 copies of said E6 mRNA per milliliter of sample or per total volume of sample tested, are scored as carrying integrated HPV and are therefore classified as high risk for development of cervical carcinoma, whereas individuals negative for expression of E6 mRNA are scored as not carrying integrated HPV and are therefore classified as no detectable risk for development of cervical carcinoma.