Patent ID: 8163780
Filing Date: 2012-04-24
Classification: A61K,A61P

Abstract:
1. A method for stimulating proliferation and mobilization of stem cells or their progeny in a mammal, the method comprising administering to a mammal a nicotine receptor agonist in an amount effective to stimulate a stem cell or progeny thereof to proliferate and to mobilize from bone marrow of the mammal to a treatment site in the mammal, wherein the nicotine receptor agonist is selected from nicotine, a nicotine salt, a nicotine derivative, a nicotine metabolite, a derivative of a nicotine metabolite, cotinine, norcotinine, nicotine N-oxide, cotinine N-oxide, 3-hydroxycotinine, and 5-hydroxycotinine, and wherein the agonist is effective to treat a disorder selected from neutropenia, leukopenia, or an acquired immunodeficiency resulting from radiation, chemotherapy, or a viral infection other than human immunodeficiency virus, or wherein the agonist is effective to increase immune cells in the mammal prior to obtaining cells from the mammal for use in bone marrow transplantation.