Patent ID: 6096514
Filing Date: 2000-08-01
Classification: A61K,C07K,C12Q,G01N

Abstract:
An isolated DNA molecule, comprising a sequence of nucleotides that encodes a .beta..sub.3-1 -subunit of a human calcium channel, wherein:the sequence of nucleotides encoding the .beta..sub.3-1 -subunit of a human calcium channel is selected from the group consisting of:(a) a sequence of nucleotides that encodes a .beta..sub.3-1 -subunit of a human calcium channel and that comprises the sequence of nucleotides set forth in SEQ ID No. 19;(b) a sequence of nucleotides that encodes a .beta..sub.3-1 -subunit of a human calcium channel, wherein:the sequence of nucleotides hybridizes along its full length under conditions of high stringency to the complement of the sequence of nucleotides set forth in SEQ ID no.19 including the portion of SEQ ID No. 19 that encodes amino acids 1-15; and the sequence of nucleotides is fully complementary to an mRNA transcript native to a human cell;(c) a sequence of nucleotides that encodes a .beta..sub.3-1 -subunit of a human calcium channel that comprises the sequence of amino acids encoded by the sequence set forth in SEQ ID Nos. 19; and(d) a sequence of nucleotides degenerate with the human calcium channel .beta..sub.3-1 -subunit-encoding sequence of (b).