Patent ID: 6911431
Filing Date: 2005-06-28
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting neovascularization in a subject in need thereof comprising: administering to said subject, for a time and under conditions effective to inhibit neovascularization, a pharmaceutical preparation comprising a pharmaceutically acceptable carrier and an amount of a compound effective to inhibit neovascularization with the formula of R′-Glu-Trp-R″, or pharmaceutically acceptable salts thereof, wherein R′ and/or R″ is absent or wherein R′ represents an alkyl group, an aryl group, an ester, an ether, an anhydride, or mixed alkyl/aryl derivative, or R′, taken together with the alpha-amino group of glutamic acid, represents an amide, or an imide, R″ represents an alkyl group, an ether, an aryl group, or mixed alkyl/aryl derivative, or R″, taken together with the carbonyl group of tryptophan represents an imide, an ester, or an anhydride, wherein R′ can also represent an amide bond between the amine of said Glu and the side chain carboxylate of said Glu, wherein neither R′ nor R″ contains amino acids, and wherein the formula weight of said compound is less than 5000 Daltons.