Patent ID: 6171603
Filing Date: 2001-01-09
Classification: A61K,A61P,A61Q,C07C,Y10S

Abstract:
A method of treating a condition selected from the group consisting of a keratinization disorder, a dermatological disorder, an ophthalmological disorder, skin aging, epidermal and/or dermal atrophy, a cicatrization disorder, auspicious function disorder, a cancerous or precancerous disease state, an inflammatory disorder, viral infection, a cardiovascular disorder, seasonally related depression, immune deficiency, by administering a therapeutically effective amount of a biaromatic amido compound having the structural formula (I): ##STR7##in which Ar is a radical (a): ##STR8##in which R.sub.5 and R.sub.6 are as defined below; Z is --CO--NR.sub.7 --; R.sub.1 is (i) a --CH.sub.3 radical, (ii) a radical --CH.sub.2 --O--R.sub.6, (iii) a radical --O--R.sub.6, (iv) a radical --CO--R.sub.8 or (v) a radical --S(O).sub.t R.sub.9, wherein R.sub.6, R.sub.8, R.sub.9 and t are as defined below; X and Y may be taken separately, in which event X is a hydrogen atom or a lower alkyl radical, and Y is a radical of the formula --(CH.sub.2).sub.n --CH.sub.3 or of the formula --(CH.sub.2).sub.n --R.sub.10, or X and Y may be taken together, in which event X and Y together form, with the carbon atom from which they depend, a single radical containing a double bond, selected from among those of the formulae .dbd.N--O--(CH.sub.2).sub.n --R.sub.10, .dbd.CH--(CH.sub.2).sub.m --R.sub.10, .dbd.N--O--(CH.sub.2).sub.2 --O--CH.sub.2 --CH.sub.3, .dbd.N--O--CH.sub.2 --O--CH.sub.2 --CH.sub.2 --O--CH.sub.3 and .dbd.CH--(CH.sub.2).sub.m --CH.sub.3, wherein R.sub.10, m and n are as defined below; R.sub.2 and R.sub.3, taken separately, are each a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, a radical --OR.sub.6 or a radical --SR.sub.6, wherein R.sub.6 is as defined below, with the proviso that R.sub.2 and R.sub.3 cannot simultaneously be a hydrogen atom, a radical --OR.sub.6 or a radical --SR.sub.6, or R.sub.2 and R.sub.3 together form, with the adjacent aromatic ring from which they depend, a 5- or 6-membered ring optionally substituted by methyl radicals and/or optionally interrupted by an oxygen or sulfur atom or by an --SO-- or --SO.sub.2 -- radical; R.sub.4 is a hydrogen atom, a halogen atom, a lower alkyl radical or a radical --OR.sub.6, wherein R.sub.6 is as defined below, with the proviso that R.sub.5 has the same definition as R.sub.4 ; R.sub.6 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms or a radical --CO--R.sub.11, wherein R.sub.11 is as defined below; R.sub.7 is a hydrogen atom or a lower alkyl radical; R.sub.8 is (a) a hydrogen atom, (b) a lower alkyl radical, (c) a radical of the formula: ##STR9##wherein R' and R"" are as defined below, or (d) a radical --OR.sub.12, wherein R.sub.12 is as defined below; R.sub.9 and R.sub.11, which may be identical or different, are each a lower alkyl radical; R.sub.10 is (i) a radical --OR.sub.6, (ii) a radical --CO--R.sub.8, (iii) a radical of the formula: ##STR10##wherein R' and R"" are as defined below, (iv) an optionally substituted aryl radical, (v) a heterocyclic radical, or (vi) a C.sub.3 or C.sub.6 cycloaliphatic radical; R .sub.12 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, an alkenyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical, or a sugar residue or an amino acid or peptide residue; R' and R"", which may be identical or different, are each a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid or peptide or sugar residue, with the proviso that R' and R"" may together form, with the nitrogen atom from which they depend, a heterocycle; m is an integer ranging from 1 to 20; n is an integer ranging from 2 to 20; and t is an integer equal to 0, 1 or 2; or a pharmaceutically/cosmetically salt or geometric or optical isomer thereof, wherein said compound is comprised in a dermatologically or pharmaceutically acceptable carrier.