Patent ID: 8911718
Filing Date: 2014-12-16
Classification: A61K,A61P,C07C,C07D,C07K,C08G,C08K

Abstract:
1. A method for preparing a polymeric reagent, comprising (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group and having the following structure, (b) protecting the first amino group and second amino group; (c) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; (d) deprotecting the first amino group and second amino group; and (e) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety, wherein the polymeric reagent has the following structure: and POLY POLY X X