Patent ID: 6056971
Filing Date: 2000-05-02
Classification: A23L,A23V,A61K

Abstract:
A method for enhancing the dissolution and bioavailability properties of Coenzyme Q.sub.10 (ubiquinone) from an orally delivered soft gelatin capsule in unit dosage form comprising filling a soft gelatin capsule with a uniform liquid non-aqueous solution containing an effective amount of Coenzyme Q.sub.10, said non-aqueous solution being produced by the following steps:mixing a non-ionic surface active agent as a solubilizer with a polyhydric alcohol to form a uniform mixture;adding an effective amount of Coenzyme Q.sub.10 for therapeutic use to said uniform mixture and mixing said Coenzyme Q.sub.10 in said uniform mixture to form said uniform non-aqueous solution, said solubilizer being included in said non-aqueous solution in an amount ranging from about 20% to about 90% by weight and said polyhydric alcohol being included in said non-aqueous solution in an amount ranging from about 2% to about 50% by weight.