Patent ID: 8313777
Filing Date: 2012-11-20
Classification: A61K,A61P,B01J,B82Y

Abstract:
1. A method for preparing polymeric nanoparticles having a lower critical solution temperature (LCST) above 37° C., comprising the steps of: dissolving in aqueous fluid to form micelles from monomers consisting of wherein said NIPAAM, said AA, and said vinyl monomer are present at molar ratios of 50-70:10-30:10-30 for NIPAAM:AA:vinyl monomer; polymerizing said micelles; removing unreacted materials from said solution; adding one or more bioactive agents to said solution and allowing said one or more bioactive agents to become entrapped within polymerized micelles in said solution or to become conjugated to the surface of said polymerized micelles in said solution, and functionalizing AA with polyethylene glycol (PEG) amine.