Patent ID: 6602993
Filing Date: 2003-08-05
Classification: A61K,C07K,Y02A

Abstract:
A DNA molecule encoding a peptide which inhibits the signaling for the cytotoxic effect by the p75 TNF receptor but does not block TNF binding to the p75 TNF receptor, said peptide comprising the antigen binding portion of an antibody which binds to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3, wherein said antibody is encoded by a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, and SEQ ID NO:10.