Patent ID: 7846652
Filing Date: 2010-12-07
Classification: A61K,C07K,G01N

Abstract:
1. A method for identifying a substance which mediates binding between interleukin-22 (IL-22) and an interleukin-22 receptor (IL-22R), comprising: a) admixing IL-22 or an IL-22R binding fragment thereof, a cell which presents an IL-22R or an IL-22 binding fragment thereof on its surface, and said substance, b) determining activation of a molecule that is expressed by said cell, said molecule selected from the group consisting of STAT1, STAT5, JAK-1, Tyk2, ERK1/2, MEK1/2, p90RSK, JNK/SAPR and p38, and c) comparing activation of said molecule to activation when said cell is admixed with IL-22 or an IL-22R binding fragment thereof in the absence of said substance, any differences therebetween indicating said substance mediates said binding.