Patent ID: 8558033
Filing Date: 2013-10-15
Classification: C07B,C07C

Abstract:
1. A process for producing an optically active fluoroalcohol, in which, under the presence of an acid and an asymmetric catalyst that is a metal complex represented by general formula (1): wherein R R R Ar is benzene that may have a substituent or a cyclopentadienyl group that may have a substituent, which binds to M via a π bond, X is an anionic group, M is ruthenium, rhodium or iridium, n denotes either 0 or 1, and when n is 0, then X is absent, and * denotes an asymmetric carbon; an aliphatic ketone having one or more fluorine atoms at α position is reacted to produce an optically active alcohol in a solvent containing water, using a formate as a hydrogen source.