Patent ID: 6649614
Filing Date: 2003-11-18
Classification: A61K

Abstract:
A method for the treatment of depression or anxiety, which method comprises the oral administration to a patient in need of such treatment or prevention of an amount of a NK-1 receptor antagonist and an amount of an antidepressant or anti-anxiety agent selected from:buspirone, citalopram, femoxetine, fluvoxamine, norfluoxetine, paroxetine, sertraline, venlafaxine, and pharmaceutically acceptable salts thereof; such that together they give effective relief, wherein said NK-1 receptor antagonist is CNS-penetrant as determined by its ability to inhibit NK-1 receptor agonist-induced foot-tapping in the gerbil, and is effective in the attenuation of separation-induced vocalisations by guinea-pig pups.