Patent ID: 6399379
Filing Date: 2002-06-04
Classification: A61K,C12N,Y02P

Abstract:
A compound 8 to 50 nucleobases in length targeted to nucleobases 1 through 9 or nucleobases 61 through 85 of a 5â€²-untranslated region, nucleobases 148 through 167, nucleobases 183 through 201, nucleobases 230 through 249, nucleobases 255 through 274, nucleobases 282 through 304, nucleobases 332 through 351, nucleobases 356 through 409, nucleobases 435 through 521, nucleobases 542 through 572, nucleobases 587 through 705, nucleobases 727 through 756, nucleobases 790 through 823, or nucleobases 828 through 847 of a coding region, a stop codon region, nucleobases 877 through 896, nucleobases 908 through 958, nucleobases 987 through 1006, nucleobases 1035 through 1060, nucleobases 1066 through 1092, nucleobases 1099 through 1177, nucleobases 1194 through 1231, or nucleobases 1284 through 1303 of a 3â€²-untranslated region of a nucleic acid molecule encoding human lnterleukin 12 p35 subunit (SEQ ID NO: 3), or nucleobases 1597-1698 of a coding region of a nucleic acid molecule encoding Interleukin 12 p35 subunit (SEQ ID NO: 10), wherein said compound specifically hybridizes with one of said regions and inhibits the expression of human Interleukin 12 p35 subunit.