Patent ID: 8815825
Filing Date: 2014-08-26
Classification: A61P,C12N

Abstract:
1. A method for reducing expression of a target β-catenin gene in a mammalian cell comprising contacting a mammalian cell in vitro with an isolated dsRNA in an amount sufficient to reduce expression of a target β-catenin gene in said cell, wherein said dsRNA comprises first and second nucleic acid strands and a duplex region of at least 25 base pairs, wherein said first strand is 25-34 nucleotides in length and said second strand of said dsRNA consists of 5′-GCUGUUUCUACAUCAUUUGUAUUCUGC-3′ (SEQ ID NO: 1239) and said dsRNA reduces β-catenin target gene expression when said double stranded nucleic acid is introduced into a mammalian cell.