Patent ID: 6335445
Filing Date: 2002-01-01
Classification: C07D

Abstract:
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, R1 and R2 are individually selected from the group consisting of hydrogen, halogen, â€”OH, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms, R3 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and â€”COR4, R4 is alkyl of 1 to 6 carbon atoms, R5 is selected from the group consisting of hydrogen, â€”OH, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms, B is selected from the group consisting of alkyl of 1 to 6 carbon atoms and carbocyclic aryl and heterocyclic aryl of 5 to 6 ring members containing in the ring 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur with the aryl unsubstituted or substituted with at least one member of the group consisting of alkyl, alkenyl and alkoxy of up to 6 carbon atoms, X is selected from the group consisting of a single bond, â€”Z1â€”, â€”Z1COâ€”, â€”CH&boxH;, â€”CH&boxH;CHâ€”COâ€”, â€”Z1â€”NR3â€”COâ€”Zâ€²1â€”, â€”CONR3â€”Zâ€²1â€”, â€”Z1â€”NR3â€”CSâ€” and â€”Z1â€”NR3â€”SO2â€”, Het is a heterocycle selected from the group consisting of oxetane, pyrrole, pyrrolidine, furan, tetrahydrofuran, thiophene, tetrahydrothiophene, sulpholane, imidazole, imidazoline, dihydroimidazole-2-one, dihydroimidazole-2-thione, oxazole, isoxazole, oxazoline, isoxazoline, oxazolidine, oxazolidinone, thiazole, thiazoline, thiazolidine, thiazolidinone, hydantoine, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,1-dioxyde-1,2,5-thiadiazolidine, 1,2,4-triazole-3-one, tetrazole, tetrahydropyridine, piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethyl-piperazine and 4-aminopiperidine, Y is selected from the group consisting of Z2â€”Qâ€”, â€”Z2COâ€”, â€”Z2â€”NHâ€”COâ€”, â€”Z2â€”CH2â€”NR3â€”COâ€”, â€”NR3â€”Z2â€”Qâ€”, â€”NR3â€”COâ€”Z2â€”Qâ€”, â€”NR3â€”NHâ€”COâ€”Z2â€”, â€”NHâ€”NHâ€”Z2â€”, â€”NR3â€”Oâ€”Z2â€”, â€”NR3â€”SO2â€”NR3â€”Z2â€”, â€”Oâ€”Z2â€”Qâ€”, â€”Oâ€”COâ€”Z2â€”Qâ€” and â€”Sâ€”Z2â€”Qâ€”, Q is selected from the group consisting of â€”Oâ€”Z3, â€”R3â€”Nâ€”Z3 and â€”Sâ€”Z3, Z1, Zâ€²1, Z2 and Z3 are individually selected from the group consisting of a single bond and alkylene of 1 to 6 carbon atoms, R6 is hydrogen or â€”OH with the proviso that when A is hydrogen, Het is not piperidine or pyrrolidino or morpholino and its non-toxic, pharmaceutically acceptable salts.