Patent ID: 6369055
Filing Date: 2002-04-09
Classification: C07D

Abstract:
A compound of formula (I) whereinring A and ring B, fused to the ring containing X and T, independently of each other represents a phenyl ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, C1-12-alkoxy, aryloxy, arylalkyl, arylalkoxy, heteroarylalkyl, heteroaryloxy, heteroarylalkoxy, acyl, acyloxy, hydroxyC1-12-alkyl, amino, acylamino, C1-12-alkyl-amino, arylamino, arylalkylamino, amino-C1-12-alkyl, C1-12-alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, C1-12-alkoxyC-1-12-alkyl, aryloxyC1-12-alkyl, arylalkoxyC1-12-alkyl, C1-12-alkylthio, thioC1-12-alkyl, C1-12-alkoxycarbonylamino, aryloxycarbonylamino, arylalkoxycarbonylamino, bicycloalkyl, (C3-6-cycloalkyl)C1-6-alkyl, C1-6-dialkylamino, C1-6-alkylsulfonyl, C1-6-monoalkylaminosulfonyl, C1-6-dialkylaminosulfonyl, arylthio, arylsulfonyl, C1-6-monoalkylaminocarbonyl, C1-6-dialkylaminocarbonyl, â€”COR6 or â€”SO2R7, wherein R6 and R7 independently of each other are selected from hydroxy, halogen, perhalomethyl, C1-6-alkoxy or amino optionally substituted with one or more C1-6-alkyl or perhalomethyl; X is â€”Oâ€”; T is N; k is 2; Ar represents arylene, heteroarylene, or a divalent heterocyclic group each of which can optionally be substituted with one or more halogen,C1-6-alkyl, amino, hydroxy, C1-6-alkoxy or aryl; R1 represents hydrogen, hydroxy, halogen, C1-12-alkoxy, C-1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; R2 represents hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-2-alkyl, C4-12-alkenynyl, C1-2-alkenyl, C2-12-alkynyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R2 forms a bond together with R3; R3 represents hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12 -alkenyl, C2-12-alkynyl, acyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R3 forms a bond together with R2; R4 represents hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylalkyl heterocyclyl, heteroaryl or heteroarylalkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; R5 represents hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylakyl, heterocyclyl, heteroaryl or heteroarylalkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; Z represents oxygen or NR12, wherein R12 represents hydrogen C1-12-alkyl, aryl, hydroxyC1-12 -alkyl or arylalkyl groups or when Z is NR12, R4 and R12 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6-alkyl; Q represents oxygen or NR13, wherein R13 represents hydrogen C1-12-alkyl, aryl, hydroxyC1-12-alkyl or arylalkyl groups or when Q is NR3, R5 and R13 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6-alkyl; n is an integer ranging from 0 to 3; m is an integer ranging from 0 to 1; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, or any tautomeric forms.