Patent ID: 6660728
Filing Date: 2003-12-09
Classification: A61P,C07D

Abstract:
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of saturated and unsaturated bivalent alkylene of up to 9 carbon atoms and bivalent cycloalkylene of 3 to 7 carbon atoms, both unsubstituted or substituted with at least one member of the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, heteroaryl of 5 to 14 carbon atoms, heteroarylalkyl of 5 to 14 hetero carbon atoms and 1 to 6 alkyl carbon atoms, cycloalkyl of 3 to 12 carbon atoms, oxo and cycloalkylalkyl of 3 to 12 cycloalkyl carbon atoms and 1 to 6 alkyl carbon atoms, B is selected from the group consisting of hydrogen, â€”NHâ€”COâ€”OR5â€”NHâ€”SO2â€”R5, â€”NHâ€”SO-Aryl of 6 to 14 carbon atoms, â€”NHâ€”SO2-heteroaryl of 5 to 14 carbon atoms, â€”NHâ€”COâ€”R5, â€”NOâ€”CO-Aryl of 6 to 14 carbon atoms, â€”NHâ€”CO-heteroaryl of 5 to 14 carbon atoms, â€”NHâ€”COâ€”NHâ€”R5, â€”NHâ€”COâ€”NH-aryl of 6 to 14 carbon atoms, â€”NHâ€”COâ€”NH-heteroaryl of 5 to 14 carbon atoms, â€”NHâ€”SO2â€”NHâ€”R5, â€”NHâ€”SO2â€”NH-aryl of 6 to 14 carbon atoms and â€”NHâ€”SO2â€”NH-heteroaryl of 5 to 14 carbon atoms, D is selected from the group consisting of hydrogen, aryl of 6 to 14 carbon atoms, heteroaryl of 5 to 14 carbon atoms and R5, R1 and R2 are individually hydrogen or unsubstituted or substituted alkyl of 1 to 6 carbon atoms with the substituents being at least one R3, R3 is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, halogen, â€”CF3, â€”OH, â€”NO2 and â€”NH2, R4 is selected from the group consisting of hydrogen, Alk-COO-Alkâ€² and alkyl of 1 to 6 carbon atoms unsubstituted or substituted with a member selected from the group consisting of â€”OH, alkoxy of 1 to 4 carbon atoms, alkyl SO2â€” of 1 to 4 carbon atoms, Alk is alkyl of 1 to 6 carbon atoms, Alkâ€² is alkyl of 1 to 4 carbon atoms, R7, R7a and R7b are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 14 carbon atoms and aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, Qâ€” is a pharmaceutically acceptable anion or R4 is selected from the group consisting of R5 is selected from the group consisting of alkyl of 1 to 14 carbon atoms unsubstituted or substituted with at least one halogen, cycloalkyl of 3 to 12 carbon atoms, cycloalkylalkyl of 3 to 12 cycloalkyl carbon atoms and 1 to 6 alkyl carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms and heteroarylalkyl of 5 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, the aryl and heteroaryl being unsubstituted or substituted with at least one R3, R6 is selected from the group consisting of hydrogen, â€”OH, â€”NO2, alkyl-OCOâ€” of 1 to 6 carbon atoms and alkyl-Oâ€”COâ€”Oâ€” of 1 to 6 carbon atoms in all stereoisomeric forms and mixtures thereof and its non-toxic, pharmaceutically acceptable addition salts with a base or acid.