Patent ID: 6516223
Filing Date: 2003-02-04
Classification: A61N,C12M

Abstract:
A device, comprising:(a) an electrode applicator having at least two pairs of electrodes arranged relative to one another to form a desired array; (b) an applicator handle having a first end detachably engaged to the electrode applicator and a second end positioned to receive at least one electrical signal from a power supply, the applicator handle configured to supply the at least one electrical signal to the electrode applicator, and (c) a power supply to provide at least one electrical signal to the second end of the applicator handle configured to supply the signal to the electrode applicator; wherein, when selected molecules are provided to a biological sample comprising cells and at least two pairs of electrodes in the electrode applicator are in electrical contact with the biological sample, the electrode applicator is operable to provide separately applied pulses of high amplitude electric signals to said at least two pairs of electrodes, but not all electrodes if there are more than two pairs of electrodes, simultaneously and proportionately to the distance between said electrodes of a pair to generate a nominal field strength of about 10 V/cm to about 1500 V/cm in the biological sample and effect introduction of the selected molecules into cells of the sample without permanently damaging the cells.