Patent ID: 9193946
Filing Date: 2015-11-24
Classification: A01N,A61K,A61P,C07K,C12N

Abstract:
1. A method for reducing the number of a recipient bacterial population comprising the steps of: (a) transferring a conjugative plasmid from a donor bacterial population to the recipient bacterial population, wherein the conjugative plasmid transfers between bacterial cells and encodes a phage receptor that binds a tectivirus phage, wherein the transferring comprises contacting the donor bacterial population with the recipient bacterial population, and wherein the recipient bacterial population is not susceptible to binding by the tectivirus phage until the recipient bacterial population expresses the phage receptor; and (b) contacting the recipient bacterial population with the tectivirus phage that binds to the phage receptor, wherein said contacting localizes the tectivirus phage to recipient bacteria expressing the tectivirus phage receptor, thereby reducing the number of the recipient bacterial population.