Patent ID: 6440571
Filing Date: 2002-08-27
Classification: A61L,C08J,G02B,Y10T

Abstract:
A method for treating the surface of a silicone medical device comprising:(a) forming a medical device from a silicone material, wherein the silicone material comprises monomeric units having reactive functionalities selected from the group consisting of azlactone, carboxylic acid, amine, hydroxy and epoxy functionalities, and combinations thereof; (b) forming a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain selected from the group consisting of azlactone, isocyanate, acid anhydride, epoxy, hydroxy, primary and secondary amine, carboxylic acid functionalities, and combinations thereof, wherein in the case of the hydroxy or amine complementary reactive functionalities, the silicone material comprises azlactone reactive functionalities and in the case of the carboxylic acid complementary functionality, the silicone material comprises epoxy reactive functionalities; and (c) reacting the hydrophilic reactive polymer of (b) having complementary reactive functionalities along the polymer chain with said reactive functionalities on or near the surface of the medical device of (a), thus forming a biocompatible surface on the medical device, wherein the polymer comprises the reaction product of 50 to 95 mole percent of hydrophilic monomers selected from the group consisting of acrylamides, lactones, poly(alkyleneoxy)methacrylates, methacrylic acid and hydroxyalkyl methacrylates and 5 to 50 mole percent of azlactone, isocyanate, acid anhydride, epoxy, hydroxy, primary amine, secondary amine or carboxylic acid containing monomers, wherein the alkyl or alkylene groups have 1 to 6 carbon atoms.