Patent ID: 8921056
Filing Date: 2014-12-30
Classification: C07K,C12Q,G01N

Abstract:
1. A method of determining whether a binding partner of a Futrin 1 polypeptide affects Wnt signaling activity, the method comprising: (a) providing a mammalian cell in culture comprising the Futrin 1 polypeptide and a Wnt inducible reporter, wherein the Futrin 1 polypeptide comprises the amino acid sequence of SEQ ID NO:26, the amino acid sequence of amino acids 21-243 of SEQ ID NO:26, the amino acid sequence of amino acids 1-146 of SEQ ID NO:26, or the amino acid sequence of amino acids 21-146 of SEQ ID NO:26, wherein the Futrin 1 polypeptide is able to promote Wnt signaling; and (b) detecting the level of reporter expression in the cell in the presence and absence of the binding partner, wherein a change in the level of reporter expression indicates that the binding partner affects the Wnt signaling.