Patent ID: 6211376
Filing Date: 2001-04-03
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula III ##STR363##wherein R.sup.1 isa) --H,b) --C.sub.1 -C.sub.5 alkyl, orc) --CH.dbd.CH-aryl;wherein R.sup.2 isa) --C.sub.1 -C.sub.10 alkyl,b) --(CH.sub.2).sub.n R.sup.3,c) --CH(R.sup.4)R.sup.3, ord) --(CH.sub.2).sub.n --X.sup.2 --R.sup.3 ;wherein R.sup.3 isa) -aryl,b) -het substituted by zero (0) to two (2) R.sup.5, orc) --C.sub.3 -C.sub.6 cycloalkyl;wherein R.sup.4 isa) --C.sub.1 -C.sub.5 alkyl, orb) -aryl;wherein X.sup.1 isa) --H,b) --F,c) --Cl,d) --Br, ore) --I;wherein X.sup.2 isa) --O--;b) --S--, orc) --NH--;where n is zero (0) to four (4) inclusive;wherein aryl isa) phenyl substituted by zero (0) to two (2) R.sup.5, orb) naphthyl substituted by zero (0) to two (2) R.sup.5 ;wherein het is a 5- or 6-membered saturated or unsaturated ring containing from one (1) to three (3) heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; optionally, het is fused to a benzene ring; and the ring can be connected through a carbon or a nitrogen in the ring;wherein R.sup.5 isa) --H,b( --CH.sub.1 -C.sub.5 alkyl,c) --F,d) --Cl,e) --OCH.sub.3,f) --CF.sub.3,g) --NHSO.sub.2 -het substituted by zero (0) to two (2) --C.sub.1 -C.sub.5 alkyl, orh) --NHSO.sub.2 -phenyl;or a pharmaceutically acceptable salt thereof.