Patent ID: 6936591
Filing Date: 2005-08-30
Classification: A61P,C07H

Abstract:
1. A process for the preparation of a substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-homoerythromycin A, wherein the procedure comprises the steps of: a) dissolving 9-deoxo-9a-aza-9a-methyl-homoerythromycin A material in b) crystallizing an orthorhombic isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A of the general Formula I: c) isolating the orthorhombic isostructural pseudopolymorph of the general Formula I; and d) converting the orthorhombic isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A of the general Formula I to a substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A.