Patent ID: 7718370
Filing Date: 2010-05-18
Classification: C12Q

Abstract:
1. A method for detecting the presence or absence of a fetal chromosomal abnormality, said method comprising: (a) determining the sequence of alleles of a locus of interest from an RNA template in a sample obtained from a pregnant female comprising maternal and fetal nucleic acid, wherein said sample is selected from the group consisting of blood, serum and plasma and further wherein said sample is obtained from the pregnant female when the fetus is at a gestational age selected from the group consisting of: 5-8, 8-12, 12-16, 16-20, 20-24, 24-28, 28-32, 32-36, 36-40, 40-44, 44-48, and 48-52 weeks; and (b) quantitating a ratio of the relative amount of alleles of said locus of interest from said RNA, wherein said ratio indicates the presence or absence of a fetal chromosomal abnormality.