Patent ID: 7351719
Filing Date: 2008-04-01
Classification: A61P,C07C,C07D

Abstract:
1. An amide compound of formula I wherein R R while in the above-defined alkylene bridge one or more H atoms may be replaced by R 14 , and while the above-defined alkylene bridge may be substituted by one or two identical or different carbo- or heterocyclic groups Cy in such a way that the bond between the alkylene bridge and the group Cy is formed via a single or double bond, via a common C atom forming a spirocyclic ring system, via two common, adjacent C and/or N atoms forming a fused bicyclic ring system or via three or more C and/or N atoms forming a bridged ring system, R X denotes a C W is selected from among —CR Z denotes a single bond, C Y is selected from among the following bivalent cyclic groups A denotes one of the meanings given for Cy, B denotes one of the meanings given for Cy, b denotes the value 0 or 1, Cy denotes a carbo- or heterocyclic group selected from one of the following: while the above-mentioned 4-, 5-, 6- or 7-membered groups may be attached via two common, adjacent C atoms fused to a phenyl or pyridine ring, and in the above-mentioned 5-, 6- or 7-membered groups one or two non-adjacent —CH 2 — groups may be replaced independently of one another by a —CO—, —C(═CH 2 )—, —(SO)— or —(SO 2 )— group, and the above-mentioned saturated 6- or 7-membered groups may also be present as bridged ring systems with an imino, N-(C 1-4 -alkyl)-imino, methylene, C 1-4 -alkyl-methylene or di-(C 1-4 -alkyl)-methylene bridge, and the above-mentioned cyclic groups may be mono- or polysubstituted at one or more C atoms with R 20 , in the case of a phenyl group they may also additionally be monosubstituted with nitro, and/or one or more NH groups may be substituted with R 21 , R R R R R R R R R R R R R R R R while in the above-mentioned groups and residues, in each case one or more C atoms may additionally be mono- or polysubstituted by F and/or in each case one or two C atoms may additionally be monosubstituted by Cl or Br independently of one another and/or in each case one or more phenyl rings may additionally, independently of one another, have one, two or three substituents selected from among F, Cl, Br, I, C 1-4 -alkyl, C 1-4 -alkoxy, difluoromethyl, trifluoromethyl, hydroxy, amino, C 1-3 -alkylamino, di-(C 1-3 -alkyl)-amino, acetylamino, aminocarbonyl, cyano, difluoromethoxy, trifluoromethoxy, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl- and di-(C 1-3 -alkyl)-amino-C 1-3 -alkyl and/or may be monosubstituted by nitro, and the H atom of any carboxy group present or an H atom bonded to an N atom may each be replaced by a group which can be cleaved in vivo, or a tautomer, the diastereomer, or enantiomers, thereof or mixtures thereof, or a salt thereof, with the following provisos (M1), and (M2) (M1) in the event that W denotes —CH═CH— and Y denotes a phenylene group and Z is a single bond, then the bridges X and Z at the phenylene ring of the group Y are in the para position to one another and at least one of the following conditions is met: (a) the group Y meaning phenylene is at least monosubstituted, (b) b has the value 0 and the group A is at least disubstituted, (c) b has the value 1; (M2) the following individual compounds are not included: 3-(4-chloro-phenyl)-N-{2-[4-(2-diethylamino-ethoxy)-phenyl]-ethyl}-acrylamide, N-{2-[3-(4-{2-[2-(4-chloro-phenoxy)-acetylamino]-ethyl}-phenoxy)-2-hydroxy -propylamino]-ethyl}-isobutyramide, cyclopentanecarboxylic acid {2-[3-(4-{2-[2-(4-chloro-phenoxy)-acetylamino]-ethyl}-phenoxy)-2-hydroxy-propylamino]-ethyl}-amide, and 2-(4-chloro-phenoxy)-N-(2-{4-[2-hydroxy-3-(2-phenylacetylamino-ethylamino)-propoxy]-phenyl}-ethyl)-acetamide.