Patent ID: 6531152
Filing Date: 2003-03-11
Classification: A61K

Abstract:
A delivery device for immediate localized release of a desired agent in the gastrointestinal tract of an animal, said device comprising:a. a core comprising said agent, a core material that swells when exposed to an aqueous liquid, and a disintegrant; and b. a rigid coating surrounding said core that disintegrates and bursts when said core swells, said coating having an outer surface, said coating comprising water-insoluble hydrophilic particulate matter embedded in a water-insoluble carrier, wherein said particulate matter forms channels in said coating that interconnect said core with said outer surface of said coating in the presence of said liquid, and wherein said core disintegrates after said coating bursts, wherein said rigidity of said coating is such that the area under the stress-strain curve of units of energy per area of coating where said coating does not tear is at least about 0.009.