Patent ID: 6048870
Filing Date: 2000-04-11
Classification: A61P,C07D

Abstract:
A compound of the formula I ##STR50## wherein (1) R.sup.1, R.sup.2 and R.sup.3 are hydrogen;(2) W, W' and W"" are the same or different and represent hydroxyl, alkoxy, thiol, thioalkyl, thioaryl, halo or amino;(3) X, X', Y, Y', Z, and Z' are the same or different and represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbons, aryl, alkoxy, aryloxy, hydroxyl, thiol, thioaryl, amino, ammonium, halogen, carboxylic acid or esters or thioesters thereof, ketone, aldehyde, carbonate, carbamate, amide, azide, imide, imine, imidazole, acetal, ketal, nitrile, diazo, nitro, hydrazine, hydrazide, hydrazone, hydroxamic acid, hydroxylamine, epoxide, alkoxy or aryloxy amine, sulfate, sulfonic or sulfinic acid or esters thereof, sulfonamide, phosphate or phosphonate acids or esters thereof, silyl, sulfoxide, sulfone, oxime, guanidino, phosphonate, thioamide, thiocarbamate, thiocyanate, thioketone, thiourea, thioethers, triazole, urea, xanthate, cyano, nitrile, --SR.sup.9 wherein R.sup.9 is alkyl, cycloalkyl, alkenyl, alkynyl, or unsaturated monocyclic hydrocarbons, and --OR where R is alkenyl, alkynyl, or unsaturated monocyclic hydrocarbons; or(i) X and Y, X' and Y, X' and Y, or X' and Y' may together form a carbocyclic, or heterocyclic ring, or Y and Z, Y and Z', or Y' and Z' may together form a carbocyclic, or heterocyclic ring;(ii) one or more of X and X' together, Y and Y' together, and Z and Z' together may form a spiro ring; or(iii) one or more of X and X' together, Y and Y' together, and Z and Z' together represent .dbd.O, .dbd.S, or .dbd.NR.sup.4 wherein R.sup.4 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbons, aryl, alkoxy, hydroxyl, or .dbd.CR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbons, or aryl;with the proviso that X, X', Y, Y', and Z, Z' cannot all be hydrogen, and when X, X', Z and Z' are hydrogen, and W, W', and W"" are hydroxyl, Y and Y' together cannot be .dbd.O or one of Y and Y' cannot be alkoxy,and pharmaceutically acceptable salts and optically active and racemic forms thereof.