Patent ID: 6329381
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A heterocyclic compound of the following formula (I): ##STR214##wherein X is sulfur atom, oxygen atom or --NR.sup.3a -- (in which R.sup.3a is hydrogen atom, C.sub.1-10 alkyl group, C.sub.3-7 cycloalkyl group, or C.sub.1-10 alkyl substituted by C.sub.3-6 cyclo-alkyl group, hydroxy group, C.sub.3-6 alkoxy group, amino group, cyano group, aryl group, aryl group substituted by C.sub.1-6 alkoxy, hydroxy or halogen, halogen atom, or nitro group, ormay form a heterocyclic ring or a substituted heterocyclic ring together with R.sup.1 via the nitrogen atom, wherein said substituent means C.sub.1-6 alkyl group, hydroxy C.sub.1-6 alkyl group, C.sub.1-6 alkoxy C.sub.1-6 alkyl group, hydroxy group, C.sub.1-6 alkoxy group, or cyano group),R.sup.1 is C.sub.1-10 alkyl group; C.sub.3-7 cycloalkyl group; C.sub.3-7 cycloalkyl substituted by C.sub.1-6 alkyl;a group selected from C.sub.1-10 alkyl group, C.sub.3-7 cycloalkyl group or C.sub.1-6 alkyl-substituted C.sub.3-7 cycloalkyl group, which is substituted byC.sub.3-6 cycloalkyl group, hydroxy group, C.sub.1-6 alkoxy group,C.sub.1-6 alkoxy group substituted by C.sub.1-6 alkoxy, hydroxy or halogen,amino group, C.sub.1-6 alkylamino group, cyano group, nitro group, acyl group, carboxyl group, C.sub.2-7 alkoxycarbonyl group, halogen atom, mercapto group, C.sub.1-6 alkylthio group,C.sub.1-6 alkylthio group substituted by C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, hydroxy or halogen, aryl group, aryl group substituted by C.sub.1-6 alkoxy, hydroxy or halogen, or heterocyclic group;aryl group;aryl group substituted byC.sub.1-6 alkyl group, hydroxy C.sub.1-6 alkyl group,C.sub.1-6 alkoxy C.sub.1-6 alkyl group, hydroxy group, C.sub.1-6 alkoxy group, cyano group, amino group, C.sub.1-6 alkylamino group, C.sub.2-7 alkoxycarbonyl group, acyl group, nitro group, halogen atom, aryl group, aryl group substituted by C.sub.1-6 alkoxy, hydroxy or halogen, or heterocyclic group;heterocyclic group; or heterocyclic group substituted byC.sub.1-6 alkyl group, hydroxy C.sub.1-6 alkyl group, C.sub.1-6 alkoxy C.sub.1-6 alkyl group, hydroxy group, C.sub.1-6 alkoxy group, cyano group, nitro group, halogen atom, amino group, C.sub.1-6 alkylamino group, C.sub.2-7 alkoxycarbonyl group, acyl group, aryl group, aryl group substituted by C.sub.1-6 alkoxy, hydroxy or halogen orheterocyclic group, andR.sup.2 is hydrogen atom, or one or more substituents on the benzene ring, and said substituent is the same or different and is hydroxy group, C.sub.1-6 alkyl group, C.sub.1-6 alkyl group substituted by hydroxy group, C.sub.1-6 alkoxy group, carboxyl, C.sub.2-7 alkoxycarbonyl group or halogen atom, C.sub.1-6 alkoxy group,C.sub.1-6 alkoxy group substituted by hydroxy group, C.sub.1-6 alkoxy group, carboxyl, C.sub.2-7 alkoxycarbonyl group or halogen atom, C.sub.1-6 alkanoyl group,C.sub.1-6 alkanoyl group substituted by hydroxy group, C.sub.1-6 alkoxy group, carboxyl, C.sub.2-7 alkoxycarbonyl group or halogen atom, aroyl group, aroyl group substituted by hydroxy group, C.sub.1-6 alkoxy group, carboxyl, C.sub.2-7 alkoxycarbonyl group or halogen atom, carboxyl group, C.sub.2-7 alkoxycarbonyl group, C.sub.2-7 alkoxycarbonyl group substituted by hydroxy group, C.sub.1-6 alkoxy group, carboxyl,C.sub.2-7 alkoxycarbonyl group or halogen atom,amino group, C.sub.1-6 alkylamino group, di(C.sub.1-6 alkyl)amino group, carbamoyl group, C.sub.1-6 alkylcarbamoyl group, di(C.sub.1-6 alkyl)carbamoyl group, halogen atom, nitro group, or cyano group,or a pharmaceutically acceptable salt thereof.