Patent ID: 6417176
Filing Date: 2002-07-09
Classification: A61P,C07F

Abstract:
A method of treating a disease state characterized by abnormally high levels of low density lipoprotein particles or cholesterol in the blood, which method comprises administering to a mammalian subject in need thereof a therapeutically effective amount of a composition comprising a compound of formula: or a pharmaceutically acceptable salt thereof, whereinR1 is a member selected from the group consisting of hydrogen, (C1-C6)alkyl and (C1-C6)heteroalkyl; R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, (C1-C8)alkyl, (C1-C8)heteroalkyl, â€”OR11 and â€”NR11R12, wherein R11 and R12 are each independently selected from the group consisting of hydrogen, (C1-C8)alkyl (C1-C8)heteroalkyl; or R2 and R3, when attached to adjacent carbon atoms, can be linked together to form a fused 5-, 6- or 7-membered ring; R4 and R5 are each independently selected from the group consisting of hydrogen, (C1-C8)alkyl, (C1-C8)heteroalkyl, aryl, heteroaryl, aryl(C1-C4)alkyl, aryl(C1-C4) heteroalkyl, heteroaryl(C1-C4)alkyl and heteroaryl(C1-C4)heteroalkyl, and are optionally linked together to form a 5-, 6- or 7-membered ring; or R4 represents a single bond to the phenyl ring bearing the phosphoryl group and R5 is selected from the group consisting of hydrogen, (C1-C8)alkyl, (C1-C8) heteroalkyl, aryl, heteroaryl, aryl(C1-C4)alkyl, aryl(C1-C4)heteroalkyl, heteroaryl(C1-C4) alkyl and heteroaryl(C1-C4)heteroalkyl; and Ar is a substituted aryl group selected from the group consisting of: whereinX1 and X2 are each independently selected from the group consisting of F, Cl and Br.