Patent ID: 7803817
Filing Date: 2010-09-28
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition in a solid dosage form selected from the group consisting of: capsules and tablets, wherein the active ingredients of said composition consist of a pharmaceutically effective amount of: (i) a parietal cell activator, wherein the parietal cell activator is a small carboxylic acid molecule which activates parietal cells, wherein the small carboxylic acid molecule is succinic acid or a salt thereof; and (ii) an irreversible gastric H + /K + -ATPase proton pump inhibitor (PPI), wherein the capsule or tablet solid dosage form is suitable for administration to a human patient, wherein the capsule or tablet solid dosage form disintegrates in the stomach and the release of the active ingredients is controlled such that the activity of the PPI is synchronized with the parietal cell activity of the carboxylic acid molecule in the stomach, the PPI is enteric-coated and formulated for absorption in the small intestine and the carboxylic acid molecule is in a form for release in the stomach in an amount sufficient to activate parietal cells located in the gastric lumen of the human patient so that the parietal cells are active while the PPI is in the patient's blood having been absorbed through the small intestine, the amount of the small carboxylic acid molecule being between 50 to 2500 mg, wherein the carboxylic acid molecule in conjunction with the PPI reduces gastric acid secretion in the stomach.