Patent ID: 6013763
Filing Date: 2000-01-11
Classification: C07K,Y10S

Abstract:
A compound represented by Formula (I)(SEQ ID NO:1) X.sub.1 -AA.sub.6 -AA.sub.7 -AA.sub.8 -AA.sub.9 -Gln-Gln-AA.sub.12 -AA.sub.13 -Phe-Tyr- (I) - Glu-Ala-Leu-His-Asp-Pro-Asn-Leu-Asn-Glu-Glu- - Gln-Arg-Asn-Ala-Lys-Ile-AA.sub.33 -Ser-Ile-AA.sub.36 -Asp- - Asp-X.sub.2 whereX.sub.1 is selected from the group consisting of H, C.sub.1 -C.sub.6 alkanoyl, and Z-Ala-Val-AA.sub.3 -AA.sub.4 -AA.sub.5 ;whereZ is selected from the group consisting of H and C.sub.1 -C.sub.6 alkanoyl;AA.sub.3 is selected from the group consisting of Asp, Arg, and Ala;AA.sub.4 is selected from the group consisting of Asn and Gln; andAA.sub.5 is selected from the group consisting of Lys, Gly, and Ser;AA.sub.6 is selected from the group consisting of Phe and Gly;AA.sub.7 is selected from the group consisting of Asn and Trp;AA.sub.8 is selected from the group consisting of Lys and Met;AA.sub.9 is selected from the group consisting of Glu, Gln, and Arg;AA.sub.12 is selected from the group consisting of Asn, Ala, and Arg;AA.sub.13 is selected from the group consisting of Ala and Arg;AA.sub.33 is selected from the group consisting of Gln and Lys;AA.sub.36 is selected from the group consisting of Lys and Arg; andX.sub.2 is selected from the group consisting of OR.sub.1 and NR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 are independently selected from the group consisting of H, C.sub.1 -C.sub.6 alkyl, C.sub.6 -C.sub.12 aryl and C.sub.6 -C.sub.12 aryl-C.sub.1 -C.sub.6 alkyl.