Patent ID: 6069148
Filing Date: 2000-05-30
Classification: A61P,C07C,C07D,C07F

Abstract:
Cycloalkano-pyridines of the formula ##STR427## in which A represents naphthyl or phenyl, each of which is optionally substituted up to 2 times in an identical or different manner by fluorine, chlorine, bromine, amino, hydroxyl, trifluoromethyl, trifluoromethoxy or by straight-chain or branched alkyl or alkoxy each having up to 6 carbon atoms,D represents phenyl which is optionally substituted by nitro, fluorine, chlorine, bromine, phenyl, trifluoromethyl or trifluoromethoxy, orrepresents a radical of the formula ##STR428## in which R.sup.5, R.sup.6 and R.sup.9 independently of one another denote cyclopropyl, cyclopentyl or cyclohexyl, or denote phenyl, naphthyl, pyridyl, pyrimidyl, indolyl, imidazolyl, benzothiozolyl, benzoxazolyl, furyl, quinolyl or purin-8-yl, where the cycles are substituted, in the case of the nitrogen-containing rings also via the N function, optionally up to 3 times in an identical or different manner by fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, cyano, carboxyl, trifluoromethoxy, straight-chain or branched acyl, alkyl, alkylthio, alkylalkoxy, alkoxy or alkoxycarbonyl each having up to 4 carbon atoms, triazolyl, tetrazolyl, benzoxathiozolyl or trifluoromethyl-substituted phenyl or phenyl, and/or are substituted by a group of the formula --OR.sup.10, --SR.sup.11 or --SO.sub.2 R.sup.12,in whichR.sup.10, R.sup.11 and R.sup.12 are identical or different and denote phenyl, which for its part is substitued up to 2 times in an identical or different manner by phenyl, fluorine, chlorine or by straight-chain or branched alkyl having up to 4 carbon atoms, orR.sup.5 or R.sup.6 denotes a radical of the formula ##STR429## R.sup.7 denotes hydrogen, fluorine, chlorine or bromine andR.sup.8 denotes hydrogen, fluorine, chlorine, bromine, azido, trifluoromethyl, hydroxyl, trifluoromethoxy, straight-chain or branched alkoxy or alkyl having up to 5 carbon atoms in each caseorR.sup.7 and R.sup.8 together form a radical of the formula .dbd.OL denotes a straight-chain or branched alkylene or alkenylene chain each having up to 6 carbon atoms, each of which is optionally substituted up to 2 times by hydroxyl,T and X are identical or different and denote a straight-chain or branched alkylene chain having up to 6 carbon atoms,orT or X denotes a bond,V represents an oxygen or sulphur atomE represents cyclopropyl, -butyl, -pentyl, -hexyl or -heptyl, or represents straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by cyclopropyl, -butyl, -hexyl, -pentyl, -heptyl or by hydroxyl, or represents phenyl which is optionally substituted by fluorine, chlorine or trifluoromethyl,R.sup.1 and R.sup.2 together form a straight-chain or branched alkylene chain having up to 6 carbon atoms, which must be substituted by an oxo group and/or by a radical of the formula ##STR430## in which a and b are identical or different and denote a number 1, 2 or 3,R.sup.19 denotes hydrogen, cyclopropyl, cyclopentyl, cyclohexyl, straight-chain or branched silylalkyl having up to 7 carbon atoms or straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl, straight-chain or branched alkoxy having up to 4 carbon atoms or by phenyl which for its part can be substituted by fluorine, chlorine, bromine, nitro, trifluoromethyl, trifluoromethoxy or by phenyl- or tetrazole-substituted phenyl,and alkyl is optionally substituted by a group of the formula --OR.sup.22, in whichR.sup.22 denotes straight-chain or branched acyl having up to 3 carbon atoms or benzyl,orR.sup.19 denotes straight-chain or branched acyl having up to 18 carbon atoms or benzoyl which is optionally substituted by fluorine, chlorine, bromine, trifluoromethyl, nitro or trifluoromethoxy, ordenotes straight-chain or branched fluoroacyl having up to 6 carbon atoms,R.sup.20 and R.sup.21 are identical or different, and denote hydrogen, phenyl or straight-chain or branched alkyl having up to 4 carbon atoms,orR.sup.20 and R.sup.21 together form a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl ring,and the carbocycles formed are optionally substituted up to 5 times in an identical or different manner, optionally also geminally, by trifluoromethyl, hydroxyl, carboxyl, azido, fluorine, chlorine, bromine, nitro, cyano, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropyloxy, cyclopentyloxy, cyclohexyloxy, by straight-chain or branched alkoxycarbonyl, alkoxy or alkylthio each having up to about 5 carbon atoms or straight-chain or branched alkyl having up to 5 carbon atoms, which for its part is substituted up to 2 times in an identical or different manner by hydroxyl, benzyloxy, benzoyl, straight-chain or branched alkoxy or oxyacyl each having up to 3 carbon atoms, trifluoromethyl and/or phenyl, which for its part can be substituted by fluorine, chlorine, bromine, trifluoromethyl or trifluoromethoxy,and/or the carbocycles formed, also geminally, are optionally substituted up to 4 times in an identical or different manner by phenyl, benzoyl, thiophenyl or sulphonylbenzyl, which for their part are optionally substituted by fluorine, chlorine, bromine, trifluoromethyl, trifluoromethoxy or nitro,and/or are optionally substituted by a radical of the formula ##STR431## in which c denotes a number 1, 2, 3 or 4,d denotes a number 0 or 1,and/or the carbocycles formed are optionally substituted by a spiro-linked radical of the formula ##STR432## in which W denotes either an oxygen or a sulphur atom,Y and Y' together form a 2- to 5-membered straight-chain or branched alkyl chain,e denotes a number 1, 2, 3, 4, 5 or 6,f denotes a number 1 or 2,R.sup.25, R.sup.26, R.sup.27, R.sup.28, R.sup.29, R.sup.30 and R.sup.31 are identical or different and denote hydrogen, trifluoromethyl, phenyl, fluorine, chlorine, bromine or straight-chain or branched alkyl or alkoxy each having up to 5 carbon atoms,orR.sup.25 and R.sup.26 or R.sup.27 and R.sup.28 in each case together form a straight-chain or branched alkyl chain having up to 5 carbon atoms orR.sup.25 and R.sup.26 or R.sup.27 and R.sup.28 in each case together form a radical of the formula ##STR433## in which W has the meaning indicated above,g denotes a number 1, 2, 3, 4, 5 or 6,and their salts and N-oxides with the exception of 5(6H)-quinolone, 3-benzoyl-7,8-dihydro-2,7,7-trimethyl-4-phenyl.