Patent ID: 6489315
Filing Date: 2002-12-03
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein ring M is a heterocyclic ring wherein â€”X{overscore (â€” â€” â€” â€” â€” â€”)} Y< is â€”COâ€”N < or â€”CSâ€”NRa and Rb are bonded to each other to form Ring A, Ring A represents a 6-membered non-aromatic heterocyclic group having 1 nitrogen atom and 5 carbon atoms and Ring B is a (i) 5-membered to 6-membered aromatic group optionally having from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to carbon atoms, (ii) a 5-membered to 9-membered non-aromatic heterocyclic group having from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to carbon atoms, or (iii) a 3-membered to 10-membered cyclic hydrocarbon group each of which may have 1 to 4 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-6 alkyl group optionally having from 1 to 5 substituents selected from (a) a hydroxyl group, (b) an amino group, (c) a carboxyl group, (d) a nitro group, (e) a mono- or di-C1-6 alkylamino group, (f) a C1-6 alkyl-carbonyloxy group and (g) a halogen atom, (3) an optionally halogenated C1-6 alkoxy group, (4) an optionally halogenated C1-6 alkylthio group, (5) a C6-10 aryl group, (6) a C1-7 acylamino group, (7) a C1-3 acyloxy group selected from the group consisting of formyloxy, acetoxy and propionyloxy, (8) a hydroxy group, (9) a nitro group, (10) a cyano group, (11) an amino group, (12) a mono- or di-C1-6 alkylamino group, (13) a 5-membered to 9-membered cyclic amino group which may have 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group, (14) a C1-6 alkylcarbonylamino group, (15) a C1-6 alkylsulfonylamino group, (16) a C1-6 alkoxycarbonyl group, (17) a carboxyl group, (18) a C1-6 alkylcarbonyl group, (19) a carbamoyl group, (20) a mono- or di-C1-6 alkylcarbamoyl group, (21) a C1-6 alkylsulfonyl group, and (22) an oxo group; the Ring C is (i) a 5-membered to 10-membered heterocyclic group which may have 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms which optionally has 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) an optionally halogenated C-1-10 alkyl group, (3) an amino-substituted C1-4 alkyl group, (4) a mono- or di-C1-4 alkylamino-substituted C1-4 alkyl group, (5) a carboxyl-substituted C1-4 alkyl group, (6) a C1-4 alkoxy-carbonyl-substituted C1-4 alkyl group, (7) a hydroxy-substituted C1-4 alkyl group, (8) a C1-4 alkoxy-carbonyl-substituted C1-4 alkyl group, (9) a C3-10 cycloalkyl group, (10) a nitro group, (11) a cyano group, (12) a hydroxyl group, (13) an optionally-halogenated C1-10 alkoxy group, (14) an optionally-halogenated C1-4 alkylthio group, (15) an amino group, (16) a mono- or di-C1-4 alkylamino group, (17) a 5-membered to 9-membered cyclic amino group optionally having 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group, (18) a C1-4 alkyl-carbonylamino group, (19) an aminocarbonyloxy group, (20) a mono- or di-C1-4 alkylaminocarbonyloxy group, (21) a C1-4 alkylsulfonylamino group, (22) a C1-4 alkoxy-carbonyl group, (23) an aralkyloxycarbonyl group, (24) a carboxyl group, (25) a C1-6 alkyl-carbonyl group, (26) a C3-6 cycloalkyl-carbonyl group, (27) a carbamoyl group, (28) a mono- or di-C1-4 alkylcarbamoyl group, (29) a C1-6 alkylsulfonyl group and (30) a 5-membered or 6-membered aromatic monocyclic heterocyclic group having 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, which may have 1 to 3 substituents selected from an optionally halogenated C1-4 alkyl; or (ii) a 3-membered to 10-membered cyclic hydrocarbon group, optionally having 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) an optionally halogenated C1-10 alkyl group, (3) an amino-substituted C1-4 alkyl group, (4) a mono- or di-C1-4 alkylamino-substituted C1-4 alkyl group, (5) a carboxyl-substituted C1-4 alkyl group, (6) a hydroxy-substituted C1-4 alkyl group, (7) a C1-4 alkoxy-carbonyl-substituted C1-4 alkyl group, (8) a C3-10 cycloalkyl group, (9) a nitro group, (10) a cyano group, (11) a hydroxyl group, (12) an optionally-halogenated C1-10 alkoxy group, (13) an optionally-halogenated C1-4 alkylthio group, (14) an amino group, (15) a mono- or di-C1-4 alkylamino group, (16) a 5-membered to 9-membered cyclic amino group optionally having 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group, (17) a C1-4 alkyl-carbonylamino group, (18) an aminocarbonyloxy group, (19) a mono- or di-C1-4 alkylaminocarbonyloxy group, (20) a C1-4 alkylsulfonylamino group, (21) a C1-4 alkoxy-carbonyl group, (22) an aralkyloxycarbonyl group, (23) a carboxyl group, (24) a C1-6 alkyl-carbonyl group, (25) a C3-6 cycloalkyl-carbonyl group, (26) a carbamoyl group, (27) a mono- or di-C1-4 alkylcarbamoyl group, (28) a C1-6 alkylsulfonyl group and (29) a 5-membered or 6-membered aromatic monocyclic heterocyclic group having 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur atoms, which may have 1 to 3 substituents selected from an optionally halogenated C1-4 alkyl; the Ring Z is a 7-membered to 9-membered heterocyclic ring having 2 nitrogen atoms and 5 to 7 carbon atoms optionally having 1 to 5 substituents selected from the group consisting of (1) a C1-6 alkyl group, (2) a C2-6 alkenyl group, (3) a C2-6 alkynyl group, (4) a C3-8 cycloalkyl group, (5) a C3-8 cycloalkyl-C1-4 alkyl group, (6) a C6-14 aryl group, (7) a nitro group, (8) a cyano group, (9) a hydroxyl group, (10) a C1-4 alkoxy group, (11) a C1-4 alkylthio group, (12) a amino group, (13) a mono- or di-C1-4 alkylamino group, (14) a 5-membered to 9-membered cyclic amino group optionally having 1 to 3 hetero atoms selected from nitrogen, oxygen and sulfur atoms, in addition to the nitrogen atom in the amino group, (15) a C1-4 alkyl-carbonylamino group, (16) a C1-4 alkylsulfonylamino group, (17) a C1-4 alkoxy-carbonyl group, (18) a carboxyl group, (19) a C1-6 alkyl-carbonyl group, (20) a carbamoyl group, (21) a mono- or di-C1-4 alkylcarbamoyl group, (22) a C1-6 alkylsulfonyl group, (23) an oxo group, and (24) a thioxo group; and n is an integer from 1 to 6, or a salt thereof.