Patent ID: 6610697
Filing Date: 2003-08-26
Classification: A61P,C07D

Abstract:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein(a) R1 is selected from the group consisting of NH2, C1-5alkylamino, diC1-5alkylamino, hydroxy, C1-5alkoxy, phenylmethylamino, heterocyclymethyl, C1-5alkylcarbonylamino, and substituted phenylcarbonylamino, wherein said phenylmethylamino and heterocyclylmethyl may be substituted on its phenyl moiety by one or more members selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, arylC1-3alkylamino, Râ€²Râ€³NCH&boxH;Nâ€” and ORâ€²â€³, the Râ€², Râ€³ and Râ€²â€³ being independently selected from H, C1-5alkyl, phenylmethyl, substituted phenylmethyl, &agr;-alkyl-phenylmethyl, substituted &agr;-alkyl-phenylmethyl, heterocyclylmethyl, and substituted heterocyclylmethyl; (b) Y is selected from the group consisting of H, halogen, heterocycle, OR4, SR4, NR4 and NR4R5, wherein R4 and R5 are independently selected from H, heterocyclyl, C3-5carbocycle, phenyl, &agr;-alkyl-phenylC1-5alkyl, straight or branched alkyl optionally substituted with R, NR, N(R)2, C3-5carbocycle, phenyl or substituted phenyt, wherein (i) R is H, halogen, C1-5alkyl, phenyl methyl, substituted phenyl methyl, SO2Ph, pyridyl, or pyridyl methyl, and (ii) said phenyl, heterocyclyl, and &agr;-alkyl-phenylC1-5alkyl may be substituted by one or more members selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, arylC1-3alkylamino, phenyl methyl, substituted phenyl methyl, Râ€²Râ€³NCH&boxH;Nâ€” and ORâ€²â€³ as defined in (a) hereof; (c) R2 is one to five members independently selected from the group consisting of halogen, trifluoromethyl, â€”NCH2PH, C1-5alkyl, and C1-5alkoxy; (d) R3 is H or, taken together, an aromatic ring; and (e) X is N or CH.