Patent ID: 6066747
Filing Date: 2000-05-23
Classification: A61P,C07D

Abstract:
A tetracyclic taxane having the formula ##STR34## wherein R.sub.1 is hydrogen, hydroxy, protected hydroxy or together with R.sub.14 forms a carbonate;R.sub.2 is hydrogen, hydroxy, or --OCOR.sub.31 ;R.sub.4a is hydrogen, alkyl, alkenyl, hydroxy, or --OCOR.sub.30 ;R.sub.7a is hydrogen, halogen, or --OR.sub.28 ;R.sub.9a is .beta.-hydroxy, .beta.-protected hydroxy, or .beta.-acyloxy;R.sub.10 is hydrogen or together with R.sub.10a forms an oxo;R.sub.10a is hydrogen, --OCOR.sub.29, hydroxy or protected hydroxy, or together with R.sub.10 forms an oxo;R.sub.13 is hydroxy or protected hydroxy;R.sub.14 is hydrogen, hydroxy, protected hydroxy, or together with R.sub.1 forms a carbonate;R.sub.28 is hydrogen, acyl, or hydroxy protecting group; andR.sub.29, R.sub.30 and R.sub.31 are independently hydrogen, alkyl, alkenyl, alkynyl, monocyclic aryl or monocyclic heteroaryl.