Patent ID: 6452026
Filing Date: 2002-09-17
Classification: C07C,C07D

Abstract:
A process for purifying an optically active threo-3- amino-1,2-epoxy compound represented by the formula (3), (where R1 is a C3-C12 hydrocarbon residual group; R2 is an amino group or a protected amino group; *2 is, if *3 is S in configuration, R in configuration and, if *3 is R in configuration, S in configuration), which comprises reacting the optically active threo-3- amino-1,2-diol derivative represented by the formula (1) (where R1, R2, *2 and *3 show the same respective meanings as described above) with an alkylsulfonyl halogenide or an arylsulfonyl halogenide for sulfonylating under the presence of a base in an organic solvent to obtain site-specifically the optically active threo-3-amino-2-hydroxysulfonate derivative represented by the formula (2) (where R1, R2, *2 and *3 show the same respective meanings as described above, and R3 is a C1-C12 hydrocarbon residual group) and then epoxydating under the presence of a base and thereafter removing selectively a by-product, namely, optically active threo-3-amino-1,2-disulfonate derivative as a depositing crystalline by using an aliphatic hydrocarbon type of solvent and utilizing difference in solubility between the epoxy compound and the by-product.