Patent ID: 7728114
Filing Date: 2010-06-01
Classification: A61K,A61P,C07K

Abstract:
1. An isolated fully human monoclonal antibody, wherein said antibody has a heavy chain with three complementarity determining regions (CDRs), comprising a VH CDR1 comprising the amino acid sequence GYGMH (SEQ ID NO:27); a VH CDR2 comprising the amino acid sequence of VIWYDGSKKYYVDSVKG (SEQ ID NO:28); and a VH CDR3 comprising the amino acid sequence of QMGYWHFDL (SEQ ID NO:29) and a light chain with three CDRs, comprising a VL CDR1 comprising the amino acid sequence of RASQSVSSYLA (SEQ ID NO:30); a VL CDR2 comprising the amino acid sequence of DASNRAT (SEQ ID NO:31); and a VL CDR3 comprising the amino acid sequence of QQRSNWPPLT (SEQ ID NO:32), wherein said antibody binds CD3.