Patent ID: 6638971
Filing Date: 2003-10-28
Classification: A23G,A23K,A61K,A61P,C07D,C07H,C11B

Abstract:
A method of inhibiting bacterial growth in a mammal suffering from, or at risk of, a bacterial infection comprising administering to the mammal a composition comprising an effective amount of a polymeric compound of the formula An, wherein A is a monomer of the following formula: wherein n is an integer from 2-18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(&agr;) â€”OH, 3-(&bgr;) â€”OH, 3-(&agr;)-O-sugar, or 3-(&bgr;)-O-sugar; bonding between adjacent monomers takes place at positions selected from the group consisting of 4, 6, and 8; a bond for additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y, and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to at least one terminal monomeric unit, bonding of the additional monomeric unit thereto is at position 4 and optionally Y&boxH;Z=hydrogen; the sugar is optionally substituted with a phenolic moiety, and pharmaceutically acceptable salts, oxidation products thereof, or combinations thereof.