Patent ID: 9023400
Filing Date: 2015-05-05
Classification: A61K,A61P

Abstract:
1. An oral pharmaceutical form resisting dose dumping in the presence of alcohol, wherein said pharmaceutical form comprises: i) coated microparticles comprising at least active principle (AP) and providing modified release of said AP; ii) at least one viscosity agent V; and iii) an agent D selected from the group consisting of: methylcellulose: hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, carboxy(alkyl)celluloses and salts thereof, and mixture thereof; wherein said AP is selected from the group consisting of: opiates, anxiolytics, benzodiazepines, anorexigens, antidepressants, antiepileptics, antiparkinsonian agents, barbiturates, hypnotics, neuroleptics, psychostimulants, psychotropic agents, amphetamines and mixtures thereof; wherein the coated microparticles of AP comprise a coating layer R; wherein said coating layer R ensures the modified release of the AP and simultaneously confers, on the coated microparticles of AP, resistance to crushing; wherein said coating layer R represents 30-60% of the total mass of the coated microparticles of AP; wherein said coating layer R comprises: wherein the viscosity agent V is in the form of microparticles distinct from the microparticles of AP, wherein the agent D is present in a mixture with the coated microparticles of AP, in the form of microparticles distinct from the microparticles of AP, or is one of the outer constituents of a monolithic form.