Patent ID: 8613933
Filing Date: 2013-12-24
Classification: A61K,A61P,C07K,C12N,G01N,Y02A

Abstract:
1. A method for eliciting an immune response in a subject, comprising administering a therapeutically effective amount of a composition comprising a poxviral vector encoding at least one costimulatory molecule and encoding a Brachyury polypeptide to a subject with a cancer selected from the group consisting of cancer of the small intestine, stomach cancer, kidney cancer, bladder cancer, uterine cancer, ovarian cancer, testicular cancer, lung cancer, breast cancer, bronchial tube cancer, colon cancer, prostate cancer, chronic lymphocytic leukemia (CLL), a B cell tumor, and a chordoma, wherein the Brachyury polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth in SEQ ID NO: 1, thereby producing an immune response to a cell expressing the Brachyury polypeptide in the subject.