Patent ID: 6140308
Filing Date: 2000-10-31
Classification: A61P,C07J

Abstract:
A method for local treatment of inflamed bowel mucosa in mammals, whereby an effective amount of a compound of the general formula GCS.sup.1 -O-Sugar.sup.1 is administered to a host in need of such treatment, wherein GCS.sup.1 is a moiety selected from the group consisting of (a) an epimeric mixture of a moiety according to formula I, ##STR8## (b) the corresponding pure 22R-epimer, (c) the corresponding pure 22S-epimer, and (d) a moiety according to formula II ##STR9## wherein X.sub.1 and X.sub.2 are independently selected from the group consisting of hydrogen, fluoro, chloro and bromo substituents; X.sub.3 is selected from the group consisting of fluoro, chloro and bromo substituents; R is a hydrocarbon chain with 1-9 carbon atoms; the 1,2-position in each of said formulas is a saturated bond or double bond; and -0-Sugar.sup.1 deonotes a sugar selected from the group consisting of a monosaccharide, a disaccharide, and an oligosaccharide, linked to the C-21 methylene group of GCS.sup.1 via a glycosidic bond, as well as a pharmaceutically acceptable salt thereof, wherein the compound GCS.sup.1 -OH is a glucocorticosteroid with a high hepatic first pass metabolism.