Patent ID: 8022225
Filing Date: 2011-09-20
Classification: A61P,C07D

Abstract:
1. A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof {where A represents an oxygen atom, R (1) (a) phenyl group(s); (2) a phenyl group substituted by 1 to 5 groups selected from (2-1) a phenyl group, (2-2) a cyano group, (2-3) a halogen atom, (2-4) an alkyl group having 1 to 6 carbon atoms, (2-5) a trifluoromethyl group, (2-6) a methoxycarbonyl group, (2-7) an alkylthio group having 1 to 6 carbon atoms, (2-8) a dimethylamino group, (2-9) a nitro group, and (2-10) an acetamido group; (3) a cycloalkyl group having 3 to 8 carbon atoms; (4) a hydroxyl group; (5) an alkylthio group having 1 to 6 carbon atoms; (6) an alkoxy group having 1 to 6 carbon atoms; (7) a benzyloxy group; (8) a phenoxy group; (9) a trifluoromethyl group; (10) a difluoromethyl group; (11) a benzenesulfonyl group; (12) a naphthyl group; (13) a tricycloalkyl group having 7 to 10 carbon atoms; (14) a 1-phenylethyl group, (15) an imidazolyl group; (16) an indolyl group; (17) a pyridyl group; (18) an oxetanyl group; (19) an oxoranyl group; (20) a methylpiperidinyl group; (21) a benzylpiperidinyl group; (22) a morpholino group; (23) a 2-oxopyrrolidin-1-yl group; (24) a 2-oxoimidazolidin-1-yl group; (25) a group represented by the formula —CO (26) a group represented by the following chemical formula 2: where R (27) a group represented by the following chemical formula 3 where R (28) a group represented by the formula where R R (29) a phenyl group; (30) an alkoxy group having 1 to 6 carbon atoms; (31) a morpholino group; (32) a piperidino group; (33) a group represented by the following chemical formula 5: where R (34) a group represented by the following chemical formula 6 where R R R R R Y represents a group represented by the formula where R 6 represents an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 10 carbon atoms that is substituted with 1 to 5 groups selected from the following groups (j) to (p): (j) a phenyl group, (k) a phenyl group substituted with 1 to 5 substituents selected from the following substituents (k-1) to (k-37): (k-1) a phenyl group, (k-2) a phenyl group substituted with a methoxy group or an acetyl group, (k-3) an oxazolyl group, (k-4) a pyrazolyl group, (k-5) a methylpyrimidinyl group, (k-6) a cyano group, (k-7) a halogen atom, (k-8) an alkyl group having 1 to 6 carbon atoms, (k-9) a trifluoromethyl group; (k-10) a trifluoromethoxy group, (k-11) a difluoromethoxy group, (k-12) a hydroxyl group, (k-13) an alkoxy group having 1 to 6 carbon atoms, (k-14) a cyanoethoxy group, (k-15) a phenoxy group, (k-16) a phenoxy group substituted with a methoxy group, (k-17) a pyridinyloxy group, (k-18) an acetyl group, (k-19) a benzoyl group, (k-20) a pyridinecarbonyl group, (k-21) a methoxycarbonyl group, (k-22) a methoxycarbonylethyl group, (k-23) an akylthio group having 1 to 6 carbon atoms, (k-24) a dimethylamino group, (k-25) a nitro group, (k-26) an acetamido group, (k-27) a sulfamoyl group, (k-28) a methanesulfonyl group, (k-29) a benzenesulfonyl group, (k-30) a pyrrolidinesulfonyl group, (k-31) a morpholinesulfonyl group, (k-32) a methylureido group, (k-33) a butylureido group, (k-34) a methoxyethylureido group, (k-35) a trimethylureido group, (k-36) a morpholinecarbonylamino group, and (k-37) a pyridinylethoxycarbonylamino group; (l) a cycloalkyl group having 3 to 8 carbon atoms, (m) a halogen atom,(n) a naphthyl group, (o) a heterocyclic group, and (p) a heterocyclic group substituted with 1 to 5 substitutes selected from the following groups (p-1) to (p-6): (p-1) a halogen atom, (p-2) an alkyl group having 1 to 6 carbon atoms, (p-3) a methoxycarbonyl group, (p-4) an ethoxcarbonyl group (p-5) a benzenesulfonyl group, and (p-6) an oxazolyl group; an alkenyl group having 2 to 8 carbon atoms that is substituted by 1 to 5 groups selected from the groups (j) to (p) mentioned above as substituents of the alkyl group; a phenyl group, a phenyl group that is substituted with 1 to 5 substituents selected from the above groups of substituents (k-1) to (k-37), a naphthyl group, a naphthyl group substituted by a dimethylamino group, a heterocyclic group, or a heterocyclic group substituted with 1 to 5 substituents selected from the above groups (p-1) to (p-6).