Patent ID: 8691501
Filing Date: 2014-04-08
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method for identifying an agent useful for treating HGPS (Hutchinson-Gilford progeria syndrome), comprising: contacting in a cell a truncated Lamin A protein, comprising an amino acid sequence encoded by LMNA Mutation 1 (G608G(GGC>GGT)) or LMNA Mutation 2 (G608S(GGC>AGC)), with a test agent under conditions sufficient to allow interaction between the protein and the test agent; and determining whether the level of the truncated Lamin A protein is reduced, wherein a test agent that is determined to reduce the level of the protein is identified as an agent useful for treating HGPS.