Patent ID: 8680245
Filing Date: 2014-03-25
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An antigen binding protein which binds human IL-13 and comprises a heavy chain amino acid sequence having a CDRH1 amino acid sequence as shown in SEQ ID NO:1; a CDRH2 amino acid sequence as shown in SEQ ID NO: 2; a CDRH3 amino acid sequence as shown in SEQ ID NO: 3 comprising one or more substitute amino acid residues selected from the group consisting of: a) a substitute amino acid residue that is a tryptophan at S95 in position 1 of the amino acid sequence shown in SEQ ID NO: 3, b) a substitute amino acid residue that is a valine at I96 in position 2 of the amino acid sequence shown in SEQ ID NO: 3, c) a substitute amino acid residue that is a phenylalanine at Y97 in position 3 of the amino acid sequence shown in SEQ ID NO: 3, d) a substitute amino acid residue that is a glutamine at D98 in position 4 of the amino acid sequence shown in SEQ ID NO: 3, e) a substitute amino acid residue that is an alanine, a glutamic acid, a glutamine, an arginine, a serine, a threonine or a valine at H100A in position 7 of the amino acid sequence shown in SEQ ID NO: 3 and f) a substituted amino acid residue that is an alanine, an isoleucine, a tryptophan or valine at Y100B in position 8 of the amino acid sequence shown in SEQ ID NO: 3; and a light chain amino acid sequence having a CDRL1 amino acid sequence as shown in SEQ ID NO:19; a CDRL2 amino acid sequence as shown in SEQ ID NO:20; and a CDRL3 amino acid sequence as shown in SEQ ID NO:21.