Patent ID: 8748619
Filing Date: 2014-06-10
Classification: C07D

Abstract:
1. A process for the resolution of omeprazole, which comprises: a) reacting 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (omeprazole) with a chiral 1,1′-bi-2-naphthol (chiral BINOL) in presence of aromatic solvent to obtain corresponding diastereomer complexes; b) isolating preferentially one diastereomer complex from the mixture of diastereomer complexes; c) reacting isolated diastereomer complex with a cyclic amine in presence of a solvent or a mixture solvents to obtain (R)- or (S)-omeprazole cyclic amine salt; and d) optionally, converting (R)- or (S)-omeprazole cyclic amine salt to the corresponding omeprazole enantiomer or a salt thereof.