Patent ID: 6214829
Filing Date: 2001-04-10
Classification: A61P,C07D

Abstract:
A compound having formula (a) ##STR25##whereinR.sub.1 is hydrogen or fluoro,R' is H or C.sub.1-4 -alkyl,R.sub.2 is H, C.sub.1-4 -alkyl, or an oxo group, or R' and R.sub.2 together represent a single bond,R"" is H or C.sub.1-4 -alkyl, and the dofted lines represent a single or double bond,p has the value 1,Y represents C,T represents N,R.sub.3 and R.sub.4 independently are hydrogen or C.sub.1-4 -alkyl,n has the value 1,Q is a group of the formula --CH.sub.2 --C(R.sub.5 R.sub.6)--Z--R.sub.7, wherein R.sub.5 and R.sub.6 represent H or C.sub.1-7 -alkyl, phenyl C.sub.1-3 -alkyl, Z represents --C(R.sub.8 R.sub.9)--O--, --C(R.sub.8 R.sub.9)--C(.dbd.O)--, --C(R.sub.8 R.sub.9)--C (.dbd.NOR.sub.10)--, --NH--C(.dbd.O)-- or --O--CH.sub.2 --, wherein R.sub.8, R.sub.9 and R.sub.10 represent H or C.sub.1-4 -alkyl; and R.sub.7 is a 5- or 6-membered cyclic group, 5- or 6-membered aromatic group or 5- or 6-membered hetero-aromatic group, or the 1- or 2-adamantyl group, which R.sub.7 group can be substituted with O--C.sub.1-4 -alkyl, CN, halogen or C--.sub.1-4 -alkyl, with the proviso that R.sub.7 cannot be 1-alkylcycloalkyl, and that compounds of formula (a) wherein Z is the group --NH--C(.dbd.O)--, R.sub.5.dbd.R.sub.6.dbd.H, T is nitrogen, and the bicyclic group is 1,4-benzoxazin-8-yl, quinoxalin-5-yl, quinolin-5-yl, indol-4-yl, benzoxazol-7-yl, benzimidazol-4-yl, or benzothiazol-7-yl are not included, or a pharmaceutically acceptable salt thereof.