Patent ID: 6750311
Filing Date: 2004-06-15
Classification: G01N,Y10T

Abstract:
A method of preparing a biocompatible polymer matrix for immobilizing a compound of the formula wherein:D1 is a dye selected from the group consisting of fluorescent dyes, luminescent dyes and calorimetric dyes; R1, R3 and R4 are each independently substituents which alter the electrode properties of the groups to which they are attached or are functional groups which can form covalent linkages to the surrounding polymer matrix; each R2 is a member independently selected from the group consisting of hydrogen or C1-C4 alkyl; each L1 and L2 is a linking group having from zero to four contiguous atoms selected from the group consisting of carbon, oxygen, nitrogen, sulfur and phosphorus; Z is a heteroatom selected from the group consisting of nitrogen, sulfur, oxygen and phosphorus; and x is an integer from zero to four, said method comprising: admixing the compound of Formula I with a diisocyanate and a hydrophilic polymer, wherein said hydrophilic polymer is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof, wherein said diisocyanate comprises about 50 mol % of the reactants in said admixture to form said biocompatible polymer matrix.