Patent ID: 6485725
Filing Date: 2002-11-26
Classification: A61P,C07K

Abstract:
An immunoglobulin preparation for intravenous injection which is stable in the solution state for at least one year at room temperature, and containsat most 5 micrograms (&mgr;g) per ml of HSA (human serum albumin), at most 16 picograms (pg) per ml of MCP-1 (human monocyte chemotactic protein-1), at most 3 micrograms (&mgr;g) per ml of C3a (activated human complement-3) and at most 1 mg per dl polyethylene glycol, and which is an immunoglobulin liquid preparation for intravenous injection which containsa chemically unmodified complete molecule immunoglobulin and has a pH value of from 5 to 6 and an electric conductivity of 1 mmho or less (calculated at 8Â° C.), wherein the preparation can be stored at room temperature for at least one year after its production andcan maintain its anticomplement titer at 20 units or less, and the dimer content of the immunoglobulin at 7% or less, constantly during the storage period, and which contains sorbitol as a stabilizer.