Patent ID: 6433151
Filing Date: 2002-08-13
Classification: A61P,C07H

Abstract:
A compound selected from the group consisting of a compound of the formula wherein R is â€”(CH2)mOn(X)â€”Yâ€”Ar, m is 0 or 1, n is 0 or 1, X is selected from the group â€”(NH)aâ€”, â€”CH2â€” and â€”SO2â€”, a is 0 or 1, Y is â€”(CH2)bâ€”(CH&boxH;CH)câ€”(CH2)dâ€”, c is 0 or 1, b+c+d&lE;8, Z is hydrogen or halogen, Ar is aryl or heteroaryl unsubstituted or substituted with at least one member of the group consisting of a) â€”OH, halogen, â€”NO2, â€”CN and b) alkyl, alkenyl, alkynyl, alkoxy, alkynloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, N-alkyl, N-alkenyl and N-alkynyl, all up to 12 carbon atoms and optionally substituted by at least one halogen, Ra and Rb are individually hydrogen or alkyl of 1 to 12 carbon atoms, R3 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, optionally substituted aryl and heteroaryl, R1 is hydrogen or methyl, W is hydrogen or acyl of an organic carboxylic acid and its non-toxic, pharmaceutically acceptable acid addition salts.