Patent ID: 8361717
Filing Date: 2013-01-29
Classification: C12Q

Abstract:
1. A magnetic particle on which a plurality of single-stranded nucleic acids are immobilized, wherein each of the plurality of single-stranded nucleic acids are immobilized on the magnetic particle through an end of the nucleic acid with a bond that is cleaved by photodegradation or chemical degradation, and each of the plurality of single-stranded nucleic acids comprises: (a) a first region at an end of the nucleic acid distal to the magnetic particle, wherein the first region of each of the plurality of single stranded nucleic acids has the same nucleotide sequence; and (b) a second region adjacent to the first region and proximal to the magnetic particle, wherein the nucleotide sequence of the second region of each of the plurality of single stranded nucleic acids is a random sequence; wherein the first region consists of 1 to 5 nucleotides having at least one bond which is not cleaved by an exonuclease that can remove the second region.