Patent ID: 6169170
Filing Date: 2001-01-02
Classification: C07H

Abstract:
A duplex oligodeoxyribonucleotide comprising two complementary strands, each complementary strand containing nucleoside subunits joined by intersubunit linkages, wherein at least one of the complementary strands comprises a non-homopolymeric defined sequence of nucleoside subunits in which (i) at least fifty percent of the intersubunit linkages are N3'.fwdarw.P5' phosphoramidate linkages and at least two of the N3'.fwdarw.N5' phosphoramidate linkages are consecutive, wherein said N3'.fwdarw.P5' phosphoramidate linkages are defined by the formula: 3'-[--NP--P(.dbd.O)(X)--O--]-5.dbd., wherein X is OH or OR, and R is C.sub.1 to C.sub.5 alkyl.