Patent ID: 6380251
Filing Date: 2002-04-30
Classification: A61K,A61P,C07B,C07C

Abstract:
A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound represented by formula I: wherein a wavy segments indicate either the &agr; or &bgr; configuration; the dashed bond represents a double bond or a single bond; Ar is selected from the group consisting of aryl or heteroaryl radicals having from 4 to 10 carbon atoms and substituted derivatives of said aryl and heteroaryl radicals; n is 0 or an integer of from 1 to 4; x and y are 1 or 0, provided that when x is 1, y is 0 and when x is 0, y is 1; R1 is hydrogen or a lower alkyl radical or a substituted lower alkyl radical having up to six carbon atoms; X is selected from the group consisting of â€”OR1 and â€”N(R1)2; Y is &boxH;O or represents 2 hydrogen radicals, Z is S or O; wherein the substituent on the lower alkyl, aryl or heteroaryl radical is selected from the group consisting of lower alkyl, hydroxy, lower alkyloxy, halogen, trifluoromethyl (CF3), COR1, COCF3, SO2NR1, SO2NH2, NO2 and CN and/or the pharmaceutically acceptable salts of said compounds and/or esters.