Patent ID: 7022330
Filing Date: 2006-04-04
Classification: A61K,A61P,C07D

Abstract:
1. A process for formulating an epothilone analog represented by formula I: and/or a pharmaceutically-acceptable salt, geometric, optical, or stereoisomer thereof, wherein: Q is M is oxygen; each R R and any salts, solvates, or hydrates thereof, comprising the following steps: a) dissolving said epothilone analog in a mixture of at least about 50% by volume tertiary-butanol in water to form a solution; b) performing primary drying of said solution at a temperature of from about −10° C. to about −40° C. under vacuum of from about 50 millitorr to about 300 millitorr for from about 24 hours to about 96 hours to form a primary lyophilized product; and c) performing secondary drying of the primary lyophilized product at a temperature of from about 10° C. to about 30° C. under vacuum of from about 50 millitorr to about 300 millitorr for from about 24 hours to about 96 hours to provide a lyophilized product of the epothilone analog.