Patent ID: 6632814
Filing Date: 2003-10-14
Classification: A61P,C07D

Abstract:
A compound of formula (Ia): wherein:R2 represents hydrogen, halogen, C1-4alkyl or C1-4alkoxy; R3 is aryl optionally substituted by aryloxy, cyano, halo C1-4alkoxy, C1-4alkyl, nitro or CF3; A1 represents ethylene; Ar1 is arylene optionally substituted by halo, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4alkylsulphinyl or C1-4alkylsulphonyl; L1 represents an ethylene linkage optionally substituted by alkyl or aryl optionally substituted by aryloxy, cyano, halo, C1-4alkoxy, C1-4alkyl, nitro or CF3; L4 represents C1-4alkylene; Y is carboxy; Z1 represents O; and the corresponding N-oxides, and their ester prodrugs; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and ester prodrugs, wherein said ester prodrugs are alkyl ester prodrugs of the Y group.