Patent ID: 6680338
Filing Date: 2004-01-20
Classification: C07C,C07D

Abstract:
A compound of formula (I)Bâ€”S(O)0-2â€”(CH2)0-1â€”CR2R3â€”CR4R5â€”COYâ€ƒâ€ƒ(I) whereinY is selected from the group consisting of OR1 and NHOH; R2 is independently selected from the group consisting of H and a moiety (optionally substituted with R10) selected from C1-6 alkyl, C2-6 alkenyl, aryl, C1-6 alkyl-aryl, cycloalkyl and C1-6 alkyl-cycloalkyl; R1 and R3 are independently selected from the group consisting of H and C1-6 alkyl; or CR2R3 is a cycloalkyl ring optionally substituted with R10 or a group (optionally substituted with R10) selected from C1-6 alkyl, aryl, and C1-6 alkyl-aryl; CR4R5 is tetrahydropyran optionally substituted with R10; B is selected from the group consisting of C1-8 alkyl, C2-6 alkenyl and C2-6 alkynyl, and is substituted with R6; R6 is selected from the group consisting of N(R7)2, OR7, COR7, C(&boxH;NOR9)R7, NR7R8, S(O)0-2,R9, and SO2N(R7)2; R7 is selected from the group consisting of H and a moiety selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, cycloalkyl, and C1-6 alkyl-cycloalkyl, wherein said moiety is optionally substituted with R9, COR9, SO0-2R9, CO2R9, OR9, CONR1R9, NR1R9, halogen, CN, SO2NR1R9 or NO2, and for each case of N(R7)2 the R7 groups are the same or different; R8 is selected from the group consisting of COR7, CON(R7)2, CO2R9 and SO2R9; R9 is selected from the group consisting of C1-6 alkyl, aryl, and C1-6 alkyl-aryl; and R10 is selected from the group consisting of OR7, COR7, CO2R1, CON(R7)2, NR7R8, S(O)0-2R9, SO2N(R7)2, CN, and halogen; or a salt, solvate, hydrate, N-oxide or protected amino, protected carboxy or protected hydroxamic acid derivative thereof.