Patent ID: 7306799
Filing Date: 2007-12-11
Classification: A61K,C07K

Abstract:
1. A therapeutic method for treating or ameliorating an eye disorder, comprising administering a fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) to a patient in need thereof, wherein the fusion polypeptide consists of an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor Flt1 and Ig domain 3 of a second VEGF receptor Flk1 or Flt4; and a multimerizing component, wherein the multimerizing component is an immunoglobulin domain or fragment of an immunoglobulin domain, wherein the eye disorder is selected from the group consisting of age related macular degeneration and diabetic retinopathy, and wherein administration is selected from the group consisting of eye drops, subconjunctival injection, subconjunctival implant, intravitreal injection, intravitreal implant, sub-Tenon's injection, and sub-Tenon's implant.