Patent ID: 6346545
Filing Date: 2002-02-12
Classification: A61P,C07C,C07D,Y02P

Abstract:
A compound of general formula I: wherein:m is 0 or 1; n is 1 or 2; A is a single bond, a straight-chained or branched C1-8-alkylene group, a C2-8-alkenylene or C2-8-alkynylene group, wherein an unsaturated group is not directly bound to the group Y; X is an oxygen or sulfur atom; Y is an oxygen or sulfur atom; R1 is a straight-chained or branched C1-8-alkyl group, a C1-6-alkenyl group, or a C1-6-alkynyl group, wherein the multiple bond is isolated from the nitrogen-carbon bond, R2 is a hydrogen atom, a straight-chained or branched C1-8-alkyl group which is optionally substituted by a hydroxy or alkoxy group, a C1-6-alkenyl group or a C1-6-alkynyl group, wherein a hydroxy and alkoxy substituent is not bound in the 1-position and a multiple bond is isolated from the nitrogen-carbon bond, or R1 and R2 together with the nitrogen atom are a 5- to 7-membered, saturated heterocyclic ring wherein a methylene group isolated from the nitrogen atom is optionally replaced by an oxygen or sulfur atom or by an â€”NHâ€” or â€”N(alkyl)- group; R3 to R6, which are identical or different, are hydrogen atoms or alkyl groups; R7 is a straight-chained or branched C1-6-alkyl group, a C1-6-alkenyl group or a C1-6-alkynyl group, wherein the multiple bond is isolated from the nitrogen-carbon bond; and R8 is a C3-7-cycloalkyl group, a phenyl or naphthyl group optionally substituted by one or two halogen atoms or by an alkyl, alkoxy, trifluoromethyl, or cyano group, wherein, unless otherwise stated, alkyl groups contained in the groups mentioned above each contain 1 to 3 carbon atoms and a halogen atom mentioned above is a fluorine, chlorine, or bromine atom, or a pharmaceutically acceptable salt thereof.