Patent ID: 9193951
Filing Date: 2015-11-24
Classification: A61K,A61P,C12N

Abstract:
1. A method for generating mammalian oligodendrocyte progenitor cells comprising: providing a pluripotent cell; inducing development of the pluripotent cell into neuroectoderm by culturing the pluripotent cell in the presence of one or more inhibitors of an activin-nodal pathway and one or more inhibitors of a bone morphogenetic protein pathway; inducing development of patterned neuroectoderm by culturing the neuroectoderm in the presence of two or more of sonic hedgehog, retinoic acid and noggin; and inducing development of oligodendrocyte progenitor cells by culturing the patterned neuroectoderm cells in the presence of one or more of a fibroblast growth factor, a platelet-derived growth factor and sonic hedgehog.