Patent ID: 6884886
Filing Date: 2005-04-26
Classification: C07D

Abstract:
1. A process for preparing a 6-aryl-4H-s-triazolo[3,4-c]-thieno [2,3-e]-1,4-diazepine of the formula I, wherein R R R in which process, (a) a 5-aryl-1,3-dihydrothieno[2,3-e]-1,4-diazepine-2-one of the formula II wherein R 1 and R 3 are as herein defined, is treated with a chlorinating agent, to produce a corresponding 5-aryl-2-chlorothieno[2,3-e]-1,4-diazepine of the formula III wherein R 1 and R 3 are as herein defined, (b) the 5-aryl-2-chlorothieno[2,3-e]-1,4-diazepine of the formula III thus obtained is reacted with an acylhydrazine of the formula IV wherein R 2 is as hereinbefore defined, and (c) the compound obtained in step (b) is treated with a base.