Patent ID: 6248746
Filing Date: 2001-06-19
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula (I): ##STR17##wherein R.sub.1 is a C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkenyl or cycloalkynyl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or cycloalkynyl is optionally substituted with hydroxy, C.sub.1-5 alkoxy, C.sub.3-5 cycloalkoxy, halogen, oxo, carbamido, hydroxycarbamido, oximido, C.sub.1-5 alkyloximido, C.sub.3-5 cycloalkyloximido, C.sub.1-5 acyloximido or C.sub.3-5 cycloacyloximido;Q is methylene or ethylene;R.sub.3 is aryl or heteroaryl wherein said aryl or heteroaryl has one to three substituents selected from the group consisting of C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkenyl, cycloalkynyl, C.sub.3-5 alkylene, C.sub.3-5 cycloalkylene, haloC.sub.1-6 alkyl, haloC.sub.1-6 cycloalkyl, C.sub.3-5 cycloalkoxy, C.sub.1-2 alkylenedioxy, C.sub.1-6 acyl, C.sub.3 -C.sub.10 cycloacyl, C.sub.1-6 acyloxy, .C.sub.3-6 cycloacyloxy, nitro or cyano;R.sub.8 is C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkynyl, or C.sub.3-5 cycloalkyl optionally substituted by hydroxy, C.sub.1-5 alkyloxy, C.sub.3-5 cycloalkyloxy, C.sub.1-5 acyloxy, benzyloxy, C.sub.3-5 cycloacyloxy or halogen.