Patent ID: 7338805
Filing Date: 2008-03-04
Classification: C07C,C07D,Y10T

Abstract:
1. A temperature-stable labeling reagent of formula (0): in which: R R L is a linking arm containing a linear succession of at least two covalent bonds and n an integer equal to 0 or 1, R A is a linking arm containing at least one covalent double bond allowing conjugation of the diazo functional group with the aromatic ring and u is an integer from 0 to 2, and —Y—X— represents —CONH—, —NHCO—, —CH wherein the labeling reagent is stable for roughly 2 days at −20° C., wherein the labeling reagent is an ortho or meta species of formula (0), and wherein the detectable marker is at least one marker capable of directly or indirectly generating a detectable signal, and the detectable marker is selected from the group consisting of an enzyme, a chromophore, a group with an electron density detectable by electron microscopy, a group with an electron density detectable by its electrical property, or a radioactive molecule.