Patent ID: 7875310
Filing Date: 2011-01-25
Classification: A61K,A61P,B01J

Abstract:
1. A method for preparing microparticles, comprising: combining a peptide solution and a polymer solution to form an emulsion, wherein the peptide solution comprises sucrose and exendin or an exendin analog, and the polymer solution comprises a biodegradable, biocompatible polymer dissolved in a halogenated solvent; combining the emulsion with a coacervating agent that is free from solvents for the polymer to form a combined phase; extracting the halogenated solvent from the combined phase with an extraction medium of a 9:1 ratio of heptane to ethanol, whereby microparticles precipitate out of the extraction medium; and rinsing the microparticles with a blend of ethanol and heptane to thereby reduce the level of residual halogenated solvent.