Patent ID: 7132444
Filing Date: 2006-11-07
Classification: C07D

Abstract:
1. A process for the preparation of trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide, a compound of the formula 1, comprising, a) reacting 3-Ethyl-4-methyl-3-pyrrolidin-2-one with a compound of formula 2,  to obtain a compound of formula 3, b) reacting a compound of formula 3 with 4-(2-Aminoethyl)benzene sulfonamide to obtain 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido)ethyl]benzene sulfonamide, a compound of formula 4, c) and further reacting the compound of formula 4 with trans-4-methylcyclohexyl isocyanate to obtain the compound of formula 1,