Patent ID: 6855689
Filing Date: 2005-02-15
Classification: A61K,A61P,C07K

Abstract:
1. A prodrug compound comprising: a targeting-peptide chosen from SEQ ID NO:6 or SEQ ID NO:7, wherein the targeting-peptide has L or L and D amino acid residues and wherein the targeting-peptide is optionally covalently capped by a terminal amino capping group Z; a linker group covalently attached to the targeting-peptide at the carboxy terminus; and a cytotoxic drug covalently attached to the linker; wherein: the targeting-peptide is an amino acid sequence which is catalytically cleaved by elastase; the linker group is a bond or a self-immolating linker; and Z is an amino protecting group chosen from tert-butyloxycarbonyl, benzyloxycarbonyl or an adhesion peptide; wherein there is an optional spacer molecule between Z and the targeting-peptide.