Patent ID: 6407059
Filing Date: 2002-06-18
Classification: A61K,C07C,C07K,Y02P

Abstract:
A backbone cyclized peptide analog, wherein the backbone is cyclized to a side-chain of an amino acid of the general formula (II): wherein d, e and f each independently designates an integer from 1 to 10; (AA) designates an amino acid residue wherein the amino acid residues in each chain may be the same or different; E represents a hydroxyl group, a carboxyl protecting or an amino group, or the E group and CO terminus of the adjacent (AA)f amino acid residue are CH2OH; R is an amino acid side chain optionally bound with a specific protecting group; and the line designates a bridging group of the Formula: (i) â€”Xâ€”Mâ€”Yâ€”Wâ€”Zâ€”; or (ii) â€”Xâ€”Mâ€”Z wherein M and W are independently selected from the group consisting of disulfide, amide, thioether, imine, ether, and alkene; X, Y and Z are each independently selected from the group consisting of alkylene, substituted alkylene, arylene, cycloalkylene and substituted cycloalkylene.