Patent ID: 6632812
Filing Date: 2003-10-14
Classification: A61P,C07D

Abstract:
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:Q is â€”(CR7R7a)mâ€”R4, â€”(CR7R7a)nâ€”Sâ€”R4, â€”(CR7R7a)nâ€”Oâ€”R4, â€”(CR7R7a)mâ€”N(R7b)â€”R4, â€”(CR7R7a)nâ€”S(&boxH;O)â€”R4, â€”(CR7R7a)nâ€”S(&boxH;O)2â€”R4, or â€”(CR7R7a)nâ€”C(&boxH;O)â€”R4; provided when n is 0, then R4 is not H; m is 1, 2, or 3; n is 0, 1, or 2; R4 is H, C1-C8 alkyl substituted with 0-3 R4a, C2-C8 alkenyl substituted with 0-3 R4a, C2-C8 alkynyl substituted with 0-3 R4a, C3-C10 carbocycle substituted with 0-3 R4b, aryl substituted with 0-3 R4b, or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R4b; R4a, at each occurrence, is independently selected from is H, Cl, F, Br, I, CN, NO2, NR15R16, CF3, OR14a, OR22, SR22, C(&boxH;O)OR22, NR21R22, S(&boxH;O)R22, S(&boxH;O)2R22, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl-Sâ€”, C3-C10 carbocycle substituted with 0-3 R4b, aryl substituted with 0-3 R4b, and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R4b; R4b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R5 is H; C1-C6 alkyl substituted with 0-3 R5b; C2-C6 alkenyl substituted with 0-3 R5b; C2-C6 alkynyl substituted with 0-3 R5b; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c; R5b, at each occurrence, is independently selected from: H, C1-C6 alkyl, CF3, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16; C3-C10 carbocycle substituted with 0-3 R5c; aryl substituted with 0-3 R5c; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c; R5c, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R6 is H; C1-C6 alkyl substituted with 0-3 R6a; C3-C10 carbocycle substituted with 0-3 R6b; or aryl substituted with 0-3 R6b; R6a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, aryl or CF3; R6b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, and C1-C4 haloalkoxy; R7, at each occurrence, is independently H or C1-C4 alkyl; R7a, at each occurrence, is independently H or C1-C4 alkyl; R7b is H or C1-C4 alkyl; Ring B is R11 at each occurrence, is independently selected from H, C1-C4 alkoxy, Cl, F, Br, I, &boxH;O, CN, NO2, NR18R19, C(&boxH;O)R17, C(&boxH;O)OR17, C(&boxH;O)NR18R19, S(&boxH;O)2NR18R19, CF3; C1-C6 alkyl optionally substituted with 0-3 R11a; aryl substituted with 0-3 R11b; C3-C10 carbocycle substituted with 0-3 R11b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R11b; R11a, at each occurrence, is independently selected from H, C1-C6 alkyl, OR14, Cl, F, Br, I, &boxH;O, CN, NO2, NR15R16, CF3; phenyl substituted with 0-3 R11b; C3-C6 cycloalkyl substituted with 0-3 R11b; and 5 to 6 membered heterocycle containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 6 membered heterocycle is substituted with 0-3 R11b; R11b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; W is a bond or â€”(CR8R8a)pâ€”; p is 0, 1, 2, 3, or 4; R8 and R8a, at each occurrence, are independently selected from H, F, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl and C3-C8 cycloalkyl; X is a bond; aryl substituted with 0-3 RXb; C3-C10 carbocycle substituted with 0-3 RXb; or 5 to 10 menibered heterocycle substituted with 0-2 RXb; RXb, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 halothioalkoxy; Y is a bond or â€”(CR9R9a)tâ€”Vâ€”(CR9R9a)uâ€”; t is 0, 1, or 2; u is 0, 1, or 2; R9 and R9a, at each occurrence, are independently selected from H, F, C1-C6 alkyl or C3-C8 cycloalkyl; V is a bond, â€”C(&boxH;O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)â€”, â€”S(&boxH;O)2â€”, â€”N(R19)â€”, â€”C(&boxH;O)NR19bâ€”, â€”NR19bC(&boxH;O)â€”, â€”NR19bS(&boxH;O)2â€”, â€”S(&boxH;O)2NR19bâ€”, â€”NR19bS(&boxH;O)â€”, â€”S(&boxH;O)NR19bâ€”, â€”C(&boxH;O)Oâ€”, or â€”OC(&boxH;O)â€”; Z is H; C1-C8 alkyl substituted with 0-3 R12a; C2-C6 alkenyl substituted with 0-3 R12a; C2-C6 alkynyl substituted with 0-3 R12a; aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12a, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, â€”C(&boxH;O)NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl-Sâ€”, aryl substituted with 0-4 R12b; C3-C10 carbocycle substituted with 0-4 R12b; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R12b; R12b, at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(&boxH;O)CH3, S(&boxH;O)2CH3, aryl, C3-C6 cycloalkyl, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-Sâ€”; R13, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, C1-C4 alkoxy, Cl, F, Br, I, CN, NO2, NR15R16, and CF3; R14 is H, phenyl, benzyl, C1-C6 alkyl, C2-C6 alkoxyalkyl, or C3-C6 cycloalkyl; R14a is H, phenyl, benzyl, or C1-C4 alkyl; R15, at each occurrence, is independently selected from H, C1-C6 alkyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R16, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; alternatively, R15 and R16, together with the nitrogen to which they are attached, may combine to form a 4-7 membered ring wherein said 4-7 membered ring optionally contains an additional heteroatom selected from O or NH; R17 is H, C1-C6 alkyl, C2-C6 alkoxyalkyl, aryl substituted by 0-4 R17a, or â€”CH2-aryl substituted by 0-4 R17a; R17a is H, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, â€”OH, F, Cl, Br, I, CF3, OCF3, SCH3, S(O)CH3, SO2CH3, â€”NH2, â€”N(CH3)2, or C1-C4 haloalkyl; R18, at each occurrence, is independently selected from H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R19, at each occurrence, is independently selected from H, OH, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(&boxH;O)â€”, and (C1-C6 alkyl)-S(&boxH;O)2â€”; R19b, at each occurrence, is independently is H or C1-C4 alkyl; R21 is H, phenyl, benzyl, or C1-C4 alkyl; and R22 is C1-C4 alkyl, C2-C4 alkenyl, or C3-C4 alkynyl.