Patent ID: 6174689
Filing Date: 2001-01-16
Classification: A61K,C07K

Abstract:
A method of screening for binding to a VESPR polypeptide, the method comprising contacting a mixture containing a semaphorin, or cells that express a semaphorin, with a VESPR polypeptide, wherein the VESPR polypeptide is selected from the group consisting ofa) polypeptide having the amino acid sequence of SEQ ID NO:2,b) polypeptide encoded by the nucleic acid of SEQ ID NO:1;c) polypeptide comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:2 and that is capable of binding a semaphorin;d) polypeptide comprising amino acids x.sub.1 to 945 of SEQ ID NO:2, wherein x.sub.1 is amino acid 1 or 35; ande) fragments of (a), (b), (c), or (d), wherein the fragment is capable of binding a semaphorin,and detecting binding to the VESPR polypeptide.