Patent ID: 6197526
Filing Date: 2001-03-06
Classification: C07K

Abstract:
A polypeptide which binds factor VIII or a fragment of factor VIII, wherein said fragment retains the procoagulant properties of factor VIII, wherein said polypeptide comprises the amino acid sequence:X.sub.10 -X.sub.11 -Cys-X.sub.12 -X.sub.13 -Trp-X.sub.14 -X.sub.15 -Pro-Cys-X.sub.16 -X.sub.17 (SEQ ID NO: 2), wherein X.sub.10 is Arg or His; X.sub.11 is Ala, Arg, Gly, Leu or Pro; X.sub.12 is Gly or Phe; X.sub.13 is Ala or Ser; X.sub.14 is Leu or Phe; X.sub.15 is Arg, Asn or His; X.sub.16 is Ala, Asp, His, Leu, Phe, Pro, or Tyr; X.sub.17 is Ala, Arg, Asn, Asp, or His.