Patent ID: 6692943
Filing Date: 2004-02-17
Classification: A61K,A61P,C07K

Abstract:
An in vitro method for expressing persephin in a cell comprising administering to said cell an amount of a nucleic acid sufficient to express persephin, wherein the nucleic acid comprises a sequence encoding a persephin polypeptide, the polypeptide comprising an amino acid sequence which contains amino acids at positions indicated in parentheses:Cys (1), Leu (3), Val (10), Leu (13), Gly (14), Leu (15), Gly (16), Tyr (17), Glu (21), Phe (25), Arg (26), Tyr (27), Cys (28), Gly (30), Cys (32), Leu (44), Leu (47), Cys (58), Cys (59), Pro (61), Asp (66), Phe (69), Leu (70), Asp (71), Ser (83), Ala (84), Cys (87), and Cys (89), said positions being identified by alignment with a mouse persephin sequence as set forth in SEQ ID NO:79 or a rat persephin sequence as set forth in SEQ ID NO:82; andwherein said persephin amino acid sequence has at least 65% sequence identity with SEQ ID NO:79 or SEQ ID NO:82.