Patent ID: 8450270
Filing Date: 2013-05-28
Classification: A61K,A61P,C07K

Abstract:
1. A glucagon peptide with glucagon agonist activity, comprising an amino acid sequence with up to 10 amino acid modifications, relative to SEQ ID NO: 1, wherein the glutamine at position 3 of SEQ ID NO: 1 is substituted with a different amino acid comprising a side chain of Structure I, II, or III: wherein R and wherein the glucagon peptide comprises (i) an intramolecular bridge which connects the side chains of an amino acid at position i and an amino acid at position i+4, wherein i is 12, 16, 20, or 24, (ii) an α,α-disubstituted amino acid at one, two, three, or all of positions 16, 20, 21, and 24, or (iii) both (i) and (ii).