Patent ID: 6270749
Filing Date: 2001-08-07
Classification: A61K,Y10S

Abstract:
A method for treating an ocular condition characterized by abnormal vasculature of a subject; the method comprising:administering a photosensitive texaphyrin to the subject where the photosensitive texaphyrin has structure I: ##STR3##or structure II: ##STR4##whereinM is a diamagnetic metal cation;R.sub.1 -R.sub.4, R.sub.7 and R.sub.8 are independently hydrogen, halide, hydroxyl, alkyl, alkenyl, alkynyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, alkoxy, hydroxyalkoxy, hydroxyalkenyl, hydroxyalkynyl, saccharide, carboxy, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aminoalkyl, a site-directing molecule, a catalytic group, or a linker that is linked to a site-directing molecule or to a catalytic group;R.sub.6 and R.sub.9 are independently selected from the groups of R.sub.1 -R.sub.4, R.sub.7 and R.sub.8, with the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl;R.sub.5 and R.sub.10 -R.sub.12 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxyalkyl, alkoxy, hydroxyalkoxy, hydroxyalkenyl, hydroxyalkynyl, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aininoalkyl, or a linker that is linked to a saccharide, to a site-directing molecule, or to a catalytic group;R.sub.13 is alkyl, alkenyl, oxyalkyl, or hydroxyalkyl having up to about 3 carbon atoms and having rotational flexibility around a first-bound carbon atom; andn is an integer value less than or equal to 5 andphotoirradiating the vasculature.