Patent ID: 6911446
Filing Date: 2005-06-28
Classification: A61P,C07D,G01N

Abstract:
1. A method of modulating the function of a serine/threonine protein kinase with a quinazoline-based compound, comprising the step of contacting cells expressing said serine/threonine kinase with said compound, or a pharmaceutically acceptable salt thereof, wherein said function of said serine/threonine protein kinase is related to a cancer selected from the group consisting of lung cancer, ovarian cancer, breast cancer, brain cancer, intra-axial brain cancer, colon cancer, prostate cancer, Kaposi's sarcoma, melanoma, and glioma; and wherein said compound has the formula set forth in formula I or III: wherein: (a) Z is oxygen, NX (b) n is 0, 1, 2, 3, or 4; (c) A provided that if any of A A (d) R (e) any adjacent R (f) R (g) Z′ is carbon or nitrogen and R