Patent ID: 9023348
Filing Date: 2015-05-05
Classification: A61K,A61P,C07K

Abstract:
1. A composition-of-matter comprising a soluble antibody including an antigen-binding region capable of specifically binding a complex composed of a human antigen-presenting molecule and an antigen derived from a human T lymphotropic virus-1 (HTLV-1) TAX polypeptide, wherein said human antigen-presenting molecule is a single chain antigen-presenting molecule, wherein said human antigen-presenting molecule comprises HLA-A2 molecule, wherein said binding of said antibody to said complex is characterized by an affinity having a dissociation constant from the range of 5×10 −8 molar to 5×10 −9 molar, wherein the antibody does not bind the human antigen-presenting molecule in an absence of the HTLV-1 TAX polypeptide, and wherein the antibody does not bind the HTLV-1 TAX polypeptide in an absence of the human antigen-presenting molecule, and whereas a monovalent or divalent configuration of said soluble antibody binds a complex comprising said antigen derived from HTLV-1 TX polypeptide when naturally presented on a cell.