Patent ID: 9005580
Filing Date: 2015-04-14
Classification: A61K,A61P

Abstract:
1. A method for treating a patient in need thereof against renal cell carcinoma, said method comprising administering to the patient a conjugate comprising a compound according to the Formula I: and a compound selected from the group consisting of: a) at least one macromolecule of sufficient molecular weight and molecular diameter to substantially or completely prevent passage of the conjugate through the glomerular filter of the kidneys and entering primary urine, wherein the at least one macromolecule is covalently bound to the compound of Formula 1, and/or b) at least one cytotoxic agent; wherein R1, R2, R3 and/or R4 in Formula I, are selected from the group consisting of: hydrogen, amino, mercapto, carboxy, phosphate and halo, including fluoro, chloro, and bromo, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 alkanol, C1-C6 alkenol, C1-C6 alkoxy, and C1-C6 alkenoxy, and wherein each of which, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 alkanol, C1-C6 alkenol, C1-C6 alkoxy, and C1-C6 alkenoxy may be further substituted with moieties selected from the group consisting of amino, mercapto, carboxy, phosphate and halo, including fluoro, chloro, and bromo, or a pharmaceutically acceptable salt thereof.