Patent ID: 6048861
Filing Date: 2000-04-11
Classification: C07D

Abstract:
A compound of the formula ##STR68## wherein X is selected from the group consisting of ##STR69## Y is selected from the group consisting of --(CH.sub.2).sub.m --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO--(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --SO.sub.2 --(CH.sub.2).sub.n --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --S--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --,--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --O--(CH.sub.2).sub.p --, and--(CH.sub.2).sub.m --S--(CH.sub.2).sub.n --NR.sup.4 --(CH.sub.2).sub.p --,wherein any methylene (CH.sub.2) carbon atom in Y, other than in R.sup.4, can be substituted by one or two R.sup.3 substituents, with the proviso that when Y is --(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n -- and n=1, then the R.sup.3 substituent on the methylene carbon in --(CH.sub.2).sub.m -- adjacent to the nitrogen cannot be oxo;Z is selected from the group consisting of ##STR70## --CH.sub.2 CH.sub.2 --, and --CH.dbd.CH--, wherein either carbon atom can be substituted by one or two R.sup.3 substituents;R.sup.1 and R.sup.2 are each independently selected from the group consisting ofhydrogen, halogen, C.sub.1-10 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloheteroalkyl, C.sub.3-8 cycloalkyl C.sub.1-6 alkyl, C.sub.3-8 cycloheteroalkyl C.sub.1-6 alkyl, aryl, aryl C.sub.1-8 alkyl, amino, amino C.sub.1-8 alkyl, C.sub.1-3 acylamino, C.sub.1-3 acylamino C.sub.1-8 alkyl, (C.sub.1-6 alkyl).sub.p amino, (C.sub.1-6 alkyl).sub.p amino C.sub.1-8 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy C.sub.1-6 alkyl, hydroxycarbonyl, hydroxycarbonyl C.sub.1-6 alkyl, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkoxycarbonyl C.sub.1-6 alkyl, hydroxycarbonyl-C.sub.1-6 alkyloxy, hydroxy, hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkyloxy-C.sub.1-6 alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, trifluoroethoxy, C.sub.1-8 alkyl-S(O).sub.p, (C.sub.1-8 alkyl).sub.p aminocarbonyl, C.sub.1-8 alkyloxycarbonylamino, (C.sub.1-8 alkyl).sub.p aminocarbonyloxy, (aryl C.sub.1-8 alkyl).sub.p amino, (aryl).sub.p amino, aryl C.sub.1-8 alkylsulfonylamino, and C.sub.1-8 alkylsulfonylamino;or two R.sup.1 substituents, when on the same carbon atom, are taken together with the carbon atom to which they are attached to form a carbonyl group;each R.sup.3 is independently selected from the group consisting ofhydrogen,aryl,C.sub.1-10 alkyl,aryl-(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --S(O).sub.p --(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,oxo,trifluoromethyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-C.tbd.C--(CH.sub.2).sub.t --,aryl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-CH.dbd.CH--(CH.sub.2).sub.t --,aryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl, and(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl;or two R.sup.3 substituents, when on the same carbon atom are taken together with the carbon atom to which they are attached to form a carbonyl group or a cyclopropyl group,wherein any of the alkyl groups of R.sup.3 are either unsubstituted or substituted with one to three R.sup.1 substituents, and provided that each R.sup.3 is selected such that in the resultant compound the carbon atom or atoms to which R.sup.3 is attached is itself attached to no more than one heteroatom;each R.sup.4 is independently selected from the group consisting ofhydrogen,aryl,aminocarbonyl,C.sub.3-8 cycloalkyl,amino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl,(aryl C.sub.1-5 alkyl).sub.p aminocarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,C.sub.1-8 alkyl,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.2-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.2-6 alkyl,C.sub.1-8 alkylsulfonyl,C.sub.1-8 alkoxycarbonyl,aryloxycarbonyl,aryl C.sub.1-8 alkoxycarbonyl,C.sub.1-8 alkylcarbonyl,arylcarbonyl,aryl C.sub.1-6 alkylcarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,aminosulfonyl,C.sub.1-8 alkylaminosulfonyl,(aryl).sub.p aminosulfonyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonyl,arylsulfonyl,arylC1-6 alkylsulfonyl,C.sub.1-6 alkylthiocarbonyl,arylthiocarbonyl, andaryl C.sub.1-6 alkylthiocarbonyl,wherein any of the alkyl groups of R.sup.4 are either unsubstituted or substituted with one to three R.sup.1 substituents;R.sup.5 and R.sup.6 are each independently selected from the group consisting ofhydrogen,C.sub.1-10 alkyl,aryl,aryl-(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --S(O).sub.p --(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-C.tbd.C--(CH.sub.2).sub.t --,aryl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-CH.dbd.CH--(CH.sub.2).sub.t --,aryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl, and(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl;or R.sup.5 and R.sup.6 are taken together with the carbon atom to which they are attached to form a carbonyl group,wherein any of the alkyl groups of R.sup.5 or R.sup.6 are either unsubstituted or substituted with one to three R.sup.1 substituents, and provided that each R.sup.5 and R.sup.6 are selected such that in the resultant compound the carbon atom to which R.sup.5 and R.sup.6 are attached is itself attached to no more than one heteroatom;R.sup.7 and R.sup.8 are each independently selected from the group consisting ofhydrogen,C.sub.1-10 alkyl,aryl,aryl-(CH.sub.2).sub.r --O--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r S(O).sub.p --(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --C(O)--N(R.sup.4)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--C(O)--(CH.sub.2).sub.s --,aryl-(CH.sub.2).sub.r --N(R.sup.4)--(CH.sub.2).sub.s --,halogen,hydroxyl,C.sub.1-8 alkylcarbonylamino,aryl C.sub.1-5 alkoxy,C.sub.1-5 alkoxycarbonyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl,C.sub.1-6 alkylcarbonyloxy,C.sub.3-8 cycloalkyl,(C.sub.1-6 alkyl).sub.p amino,amino C.sub.1-6 alkyl,arylaminocarbonyl,aryl C.sub.1-5 alkylaminocarbonyl,aminocarbonyl,aminocarbonyl C.sub.1-6 alkyl,hydroxycarbonyl,hydroxycarbonyl C.sub.1-6 alkyl,HC.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-C.tbd.C--(CH.sub.2).sub.t --,aryl-C.tbd.C--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-C.tbd.C--(CH.sub.2).sub.t --,CH.sub.2 .dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.3-7 cycloalkyl-CH.dbd.CH--(CH.sub.2).sub.t --,aryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-CH.dbd.CH--(CH.sub.2).sub.t --,C.sub.1-6 alkyl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkylaryl-SO.sub.2 --(CH.sub.2).sub.t --,C.sub.1-6 alkoxy,aryl C.sub.1-6 alkoxy,aryl C.sub.1-6 alkyl,(C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,(aryl).sub.p amino,(aryl).sub.p amino C.sub.1-6 alkyl,(aryl C.sub.1-6 alkyl).sub.p amino,(aryl C.sub.1-6 alkyl).sub.p amino C.sub.1-6 alkyl,arylcarbonyloxy,aryl C.sub.1-6 alkylcarbonyloxy,(C.sub.1-6 alkyl).sub.p aminocarbonyloxy,C.sub.1-8 alkylsulfonylamino,arylcarbonylamino,arylsulfonylamino,C.sub.1-8 alkylsulfonylamino C.sub.1-6 alkyl,arylsulfonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonylamino,aryl C.sub.1-6 alkylsulfonylamino C.sub.1-6 alkyl,C.sub.1-8 alkoxycarbonylamino,C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,aryloxycarbonylamino C.sub.1-8 alkyl,aryl C.sub.1-8 alkoxycarbonylamino,aryl C.sub.1-8 alkoxycarbonylamino C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonylamino C.sub.1-6 alkyl,arylcarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonylamino,aryl C.sub.1-6 alkylcarbonylamino C.sub.1-6 alkyl,aminocarbonylamino C.sub.1-6 alkyl,arylaminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino,(C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl).sub.p aminocarbonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino,(aryl C.sub.1-8 alkyl).sub.p aminocarbonylamino C.sub.1-6 alkyl,aminosulfonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminosulfonylamino,(C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl).sub.p aminosulfonylamino C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino,(aryl C.sub.1-8 alkyl).sub.p aminosulfonylamino C.sub.1-6 alkyl,C.sub.1-6 alkylsulfonyl,C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,arylsulfonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylsulfonyl,aryl C.sub.1-6 alkylsulfonyl C.sub.1-6 alkyl,C.sub.1-6 alkylcarbonyl,C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,arylcarbonyl C.sub.1-6 alkyl,aryl C.sub.1-6 alkylcarbonyl,aryl C.sub.1-6 alkylcarbonyl C.sub.1-6 alkyl,C.sub.1-6 alkylthiocarbonylamino,C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,arylthiocarbonylamino C.sub.1-6 alkyl,aryl C.sub.1-6 alkylthiocarbonylamino,aryl C.sub.1-6 alkylthiocarbonylamino C.sub.1-6 alkyl,(C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl).sub.p aminocarbonyl C.sub.1-6 alkyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl,(aryl C.sub.1-8 alkyl).sub.p aminocarbonyl C.sub.1-6 alkyl, andC.sub.7-20 polycyclyl C.sub.0-8 alkylsulfonylamino,wherein any of the alkyl groups of R.sup.7 and R.sup.8 are either unsubstituted or substituted with one to three R.sup.1 substituents, and provided that each R.sup.7 and R.sup.8 are selected such that in the resultant compound the carbon atom to which R.sup.7 and R.sup.8 are attached is itself attached to no more than one heteroatom;R.sup.9 is selected from the group consisting ofhydrogen,C.sub.1-8 alkyl,aryl,aryl C.sub.1-8 alkyl,C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,aryl C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyl,C.sub.1-8 alkylaminocarbonylmethylene, andC.sub.1-8 dialkylaminocarbonylmethylene;whereineach m is independently an integer from 0 to 6;each n is independently an integer from 0 to 6;each p is independently an integer from 0 to 2;each r is independently an integer from 1 to 3;each s is independently an integer from 0 to 3; andeach t is independently an integer from 0 to 3;and the pharmaceutically acceptable salts thereof.