Patent ID: 6436908
Filing Date: 2002-08-20
Classification: A61K,C12N

Abstract:
A method of inhibiting the activity of a beta adrenergic receptor kinase 1 (&bgr;ARK1) so as to improve myocardial function in a mammal, comprising administering to the cardiac muscle of said mammal via cardiac perfusion an effective amount of an expression vector comprising a promoter active in myocardium operably linked to a DNA sequence encoding a &bgr;ARK1 inhibitor, wherein said inhibitor comprises a &bgr;ARK1 carboxyl terminal sequence comprising &bgr;ARK1 residues Trp643 to Ser670 (SEQ ID NO:1), and wherein expression of said &bgr;ARK1 inhibitor results in an increase in myocardial function.