Patent ID: 7166731
Filing Date: 2007-01-23
Classification: C07C,C07F

Abstract:
1. A method of preparing a 1,4,6-substituted, 1,4-substituted, 1,6-substituted, or 1-substituted fulvene compound comprising a) reacting Formula I below with a compound of Formula IIa or IIb below to prepare a compound of Formula III below; b) lithiating the compound of the Formula III, and then reacting the resulting lithium salt with an electrophile of Formula IV below to prepare a compound of Formula V below; c) reacting more than one equivalent of the compound of the Formula V with a compound of Formula VI below to prepare an ether, and then dehydrating with an acid catalyst to prepare a compound of Formula VII below; and d) adding a base to the compound of the Formula VII to prepare a fulvene compound of Formula VIII wherein R R X is a halogen atom; R Y is a leaving group formed by a nucleophilic substitution reaction.