Patent ID: 9139612
Filing Date: 2015-09-22
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A compound of formula I: wherein X is selected from a ketone-containing active agent, wherein the hydrogen atom of the corresponding hydroxyl group of the enolic tautomer of the ketone is replaced by a covalent bond to —C(O)—N[(A ring)-Y the A ring is a heterocyclic 5 to 12-membered ring; each Y is independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, acyl, substituted acyl, carboxyl, alkoxycarbonyl, substituted alkoxycarbonyl, aminoacyl, substituted aminoacyl, amino, substituted amino, acylamino, substituted acylamino, and cyano; c is a number from zero to 3; each R each R R a is an integer from one to 8; provided that when a is one, the A ring is a heterocyclic 6 to 12-membered ring; and when the A ring is a heterocyclic 5-membered ring, then a is an integer from 2 to 8; each R R each R b is a number from zero to 100; and R or a salt, hydrate or solvate thereof.