Patent ID: 9035045
Filing Date: 2015-05-19
Classification: A61K,B01F,C08B,C08J,C08L

Abstract:
1. A process for preparing a partially cross-linked homogenous liquid alginate solution that maintains a liquid state in storage at room temperature for at least 24 hours comprising: providing a first aqueous solution comprising a monovalent alginate salt; providing a second aqueous solution comprising a divalent cation salt; and uniformly mixing the first aqueous solution and the second aqueous solution in a microfluidic multilamination mixing process to provide the partially cross-linked homogenous liquid alginate solution, wherein the alginate has a molecular weight ranging from about 10 to about 100 kDa, the alginate concentration in the partially cross-linked homogenous liquid alginate solution is in the range of 0.8 to 1.5% w/v, and the divalent cation concentration in the partially cross-linked homogenous liquid alginate solution is in the range of 0.02 to 0.04% w/v.