Patent ID: 7592138
Filing Date: 2009-09-22
Classification: C12Q,G01N

Abstract:
1. A method for distinguishing ischemic from nonischemic cardiomyopathy, comprising the steps of: (a) obtaining a clinical specimen from a patient suffering from cardiomyopathy; (b) detecting the expression level(s) of a set of genes in the clinical specimen, wherein the set of genes comprises the following genes: RPL23AP7, ENIGMA, MLLT7, CIZ1, CDC2L5, CDKN1C, HIST1H4G, ATF5, GEMIN4, MIS12, SNTB2, PTK9L, DMN, SACM1L, ELAVL3, APOL2, SAA2, IGHM, BAT2, SLC39A8, PPP2CB, PPP3CC, PSD, ZFPL1, GYG2, ZNF205, MGC31957, SAFB2, MRPS18A, ABCB8, HR, PPARD, OAZIN, GABPB1, TRIM33, PTAFR, CENTB 1, MAP2K7, PNUTL1, RASGRP2, DLG4, CENTA1, AGER, RE2, RHEB, SPN, THRA, ECE1, SIGLEC8, TRPV6, AMH, BOK, MRC2, CHK, NPR3, MAPK8IP1, KIAA1354, GNG12, SCN2B, FLJ12242, TGOLN2, SEC24A, MAST205, MGC40499, FLJ20699, SFTPC, EPHB4, MGC4293, DUX4, SLIT1, FLJ22349, GRCA, THG-1, MGC4659, DDX49, GNRPX, MTVR1, MYCBP, KIN, HSA277841, NPM1 and WAG; (c) comparing the expression level(s) of the set of genes in the clinical specimen with expression level(s) of a gene expression prediction profile associated with ischemic or nonischemic cardiomyopathy.