Patent ID: 8476260
Filing Date: 2013-07-02
Classification: A61K,A61P,C07D

Abstract:
1. A method of shrinking, killing, or inhibiting the growth of cancer cells in a mammal, comprising administering an effective amount of a thienotriazolodiazepine compound represented by the following formula (I) wherein R R R R or a pharmaceutically acceptable salt thereof or (S)-2-[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide dihydrate to a mammal with cancer cells, wherein the cancer is hematologic cancer, myeloma, liver cancer, ovarian cancer, prostate cancer, lung cancer, osteosarcoma, or colorectal cancer, whereupon the cancer cells are shrunk or killed in the mammal or the growth of the cancer cells is inhibited in the mammal.