Patent ID: 8252320
Filing Date: 2012-08-28
Classification: A61F,A61K,A61P

Abstract:
1. A transdermal delivery system, comprising: a pressure-sensitive adhesive matrix comprising sufentanil in an amount above the saturation point of sufentanil in the matrix, wherein the matrix comprises: both dissolved and undissolved sufentanil, and a blend of high molecular weight polyisobutylene and low molecular weight polyisobutylene, the high molecular weight polyisobutylene having a viscosity average molecular weight of about 450,000 to 2,100,000, the low molecular weight polyisobutylene having a viscosity average molecular weight of about 1,000 to 450,000, polybutene, and silicon dioxide; wherein the system, when applied to a subject as a single patch, provides delivery of sufentanil over a single application administration period of 48 hours sufficient to establish and maintain a plasma sufentanil concentration having a maximum to minimum ratio of 1.8 or less over the administration period; and wherein the system does not comprise a rate controlling membrane.