Patent ID: 6696434
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound of formula I whereinX is L2Z2; L2 is (CR3aR3b)p-Z4-(CR3â€²aR3â€²b)q; Z1 is CH; Z2 is cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclyl, substituted heterocyclyl, heterocyclenyl, or substituted heterocyclenyl; Z4 is O, NR4, S, SO, or SO2; p and q are independently 0, 1, 2, 3 or 4, and p+q=0, 1, 2 or 3 ; R1a R1b are independently alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R5R6Nâ€” or acylR5Nâ€”, or one of R1a and R1b is hydrogen or halo and the other is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R5R6Nâ€” or acylR5Nâ€”; R1c is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, halo, cyano, R5R6Nâ€” or acylR5Nâ€”; R3a, R3b, R3â€²a and R3â€²b are independently hydrogen or alkyl; R4 is hydrogen, alkyl or acyl; and R5 and R6 are independently hydrogen or alkyl, or R5 and R6 are both alkyl which, when taken together with the nitrogen atom to which R5 and R6 are attached, form azaheterocyclyl, or a quinoline N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof.