Patent ID: 8937154
Filing Date: 2015-01-20
Classification: A61K,A61P,C07K

Abstract:
1. A peptide comprising an amino acid sequence I(T/S)FE(D/E)(L/I/W)L(D/Q)YY (SEQ ID NO:21), wherein two of the amino acids are substituted with unnatural amino acids (S)-α-2-(4′-pentenyl)alanine or (S)-α-2-(7′-octanyl)alanine, wherein olefinic groups of the unnatural amino acids are on the same side of the α-helix and are joined to form a cross-link between the two unnatural amino acids, wherein the two unnatural amino acids replace two of the amino acids at positions four amino acids apart (i and i+4) or seven amino acids apart (i and i+7), and the amino acid sequence is one of SEQ ID NOs:7-9 or 11-18.