Patent ID: 7820804
Filing Date: 2010-10-26
Classification: A61P,C07H

Abstract:
1. A compound of formula I wherein: R1 and R2 are, independently of one another, F or H, with the proviso that one of R1 or R2 must be F; A is O, NH or S; R3 is selected from hydrogen, F, Cl, Br, I, OH, CF wherein any or all of the hydrogens of said alkyl, alkenyl, alkynyl and O-alkyl radicals may also be replaced by fluorine; wherein o is an integer from 0 to 6, and each said phenyl radical may be substituted up to twice by a substituent selected from F, Cl, Br, OH, CF wherein o is an integer from 0 to 6, and said phenyl ring may be substituted one to three times by a substituent selected from F, Cl, Br, I, OH, CF R4 is selected from hydrogen, (C B is (C R5, R6, R7 are independently of one another, selected from hydrogen, F, Cl, Br, I, OH, CF wherein any or all of the hydrogens of said alkyl, alkenyl, alkynyl and O-alkyl radicals may also be replaced by fluorine; wherein o is an integer from 0 to 6, and said phenyl ring may be substituted one to two times by a substituent selected from F, Cl, Br, OH, CF wherein o is an integer from 0 to 6, and said phenyl ring may be substituted one to three times by a substituent selected from F, Cl, Br, I, OH, CF R6 and R7, together with the C atoms to which they are attached, form a 5 to 7 membered, saturated, partially or completely unsaturated ring, Cyc1, wherein 1 or 2 C atoms of the ring may also be replaced by N, O or S, and Cyc1 may optionally be substituted by a substituent selected from (C wherein, in each case, one CH X is CO, O, NH, S, SO, SO L is selected from (C wherein, in each case, one or two CH Y is CO, NHCO, SO, SO R8, and R9, independently of one another, are selected from hydrogen, SO wherein one or more CH R8 and R9, together with the N atom to which they are attached, form a 5 to 7 membered, saturated ring, Cyc2, wherein one or more CH wherein one or more CH and the pharmaceutically acceptable salts thereof.