Patent ID: 8633277
Filing Date: 2014-01-21
Classification: A61K,C08G

Abstract:
1. A method of preparing a conjugate comprising the step of contacting a polymeric reagent with an active agent under suitable conjugation conditions to thereby provide the conjugate, wherein the polymeric reagent has the following structure wherein: POLY POLY (a) is 0, 1, 2 or 3; (b) is 0, 1, 2 or 3; (e) is 0, 1, 2 or 3; (f′) is 0, 1, 2 or 3; (g′) is 0, 1, 2 or 3; (h) is 0, 1, 2 or 3; (j) is 0 to 20; each R X X X X X X R  wherein (p) is 1-10 and (q) is 1-10; and Z is a reactive group suitable for reaction with an electrophile or nucleophile of the active agent.