Patent ID: 6528306
Filing Date: 2003-03-04
Classification: A61K,A61P,C12N

Abstract:
The living progeny cells of a genetically modified human neural stem cell, wherein said living progeny cells are maintained in-vitro as a stable cell line and suitable for on-demand implantation in-vivo into a living host subject, said living progeny cells comprising:multipotent descendant cells of human neural stem cell origin which (i) remain undifferentiated while maintained in-vitro as mitotic cells; (ii) are implantable in-vivo at a chosen implantation site as undifferentiated cells; (iii) optionally migrate in-vivo after implantation from the implantation site to another anatomic site for integration within the nervous system of the living host subject; (iv) integrate in-situ after implantation into the parenchymal tissues at a local anatomic site in the living host subject; and (v) differentiate in-situ after integration into at least one fundamental cell type selected from the group consisting of neurons, oligodendroglia, and astroglia; and human genomic DNA genetically modified to include a viral vector carrying at least one DNA segment comprised of an exogenous gene coding for a specific protein.