Patent ID: 7649009
Filing Date: 2010-01-19
Classification: A61P,C07D

Abstract:
1. A compound represented by formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: Y represents —C(O)—N(R one of A and B represents —C(O)—NH—R R a) C 1-16 alkyl optionally substituted with: (1) 1-5 halo groups up to a perhaloalkyl group; (2) 1 oxo group; (3) 1-2 OH groups; (4) 1-2 C (5) 1 CO (6) 1-2 Aryl, Hetcy or HAR groups, each optionally substituted as follows: b) Aryl, HAR, Hetcy, each optionally substituted as set forth below: (1) 1-3 C (2) phenyl optionally substituted as follows: (i) 1-5 halo groups, (ii) 1 CO said Aryl, HAR, Hetcy group b) being further optionally substituted on carbon by a group selected from the group consisting of; (3) 1-5 halo groups; (4) 1-2 OH groups; (5) 1 S(O) (6) 1-2 CO (7) —C(O)NR each R (a) halo, OH, CO (b) C R R R R R R R (a) C (b) Aryl or Ar—C (c) Hetcy or Hetcy-C (d) HAR or HAR-C R m is an integer selected from 0, 1 and 2; n is an integer selected from 0 to 6; p is an integer selected from 0, 1 and 2, and when at least one of m and n is other than 0, Z is selected from CO X is CH or N.