Patent ID: 7820170
Filing Date: 2010-10-26
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
1. A human anti-CD40 monoclonal antibody or an antigen-binding fragment thereof, wherein said anti-CD40 antibody or fragment thereof exhibits antagonist activity when said antibody or fragment thereof binds a CD40 antigen on a malignant human B cell, wherein said human anti-CD40 monoclonal antibody is selected from the group consisting of: a) a monoclonal antibody comprising a light chain variable region having the amino acid sequence set forth in SEQ ID NO:2; b) a monoclonal antibody comprising a heavy chain variable region having the amino acid sequence set forth in SEQ ID NO:4; c) a monoclonal antibody having a light chain variable region having the amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO:1; d) a monoclonal antibody having a heavy chain variable region having the amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO:3; and e) a monoclonal antibody that comprises the complementarity determining regions (CDRs) of the monoclonal antibody produced by hybridoma cell line 15B8 (Patent Deposit Designation PTA-3814); wherein said antigen-binding fragment of said antibody retains the capability of specifically binding to human CD40.