Patent ID: 6479666
Filing Date: 2002-11-12
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula: wherein x is R18 is aryl, heteroaryl, aryl lower alkyl, heteroaryl lower alkyl; R19 is substituted or unsubstituted lower alkyl, aryl, heteroaryl, arylalkyl, heteroaryl alkyl, and R20 is substituted or unsubstituted lower alkanoyl or aroyl; Y is a ring of the formula R22 and R23 are independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, aryl, arylalkyl, nitro, cyano, lower alkylthio, lower alkylsulfinyl, lower alkyl sulfonyl, lower alkanoyl, halogen, or perfluorolower alkyl and at least one of R22 and R23 is other than hydrogen, and R24 is hydrogen, lower alkyl, lower alkoxy, aryl, nitro, cyano, lower alkyl sulfonyl, or halogen; or Y is a group of the formula: Het is a five or six membered heteroaromatic ring bonded via a carbon atom wherein said ring contains one, two or three heteroatoms selected from the group consisting of N, O and S and R30 and R31 are independently hydrogen, lower alkyl, cycloalkyl, halogen, cyano, perfluoroalkyl, or aryl and at least one of R30 and R31 is adjacent to the point of attachment; p is an integer of from 0 to 1;or Y is a ring of the formula R25 is lower alkyl, unsubstituted or fluorine substituted lower alkenyl, or a group of formula R26â€”(CH2)eâ€”, R26 is aryl, heteroaryl, azido, cyano, hydroxy, lower alkoxy, lower alkoxycarbonyl, lower alkanoyl, lower alkylthio , lower alkyl sulfonyl, lower alkyl sulfinyl, perfluoro lower alkanoyl, nitro, or R26 is a group of formula â€”NR28R29; R28 is H or lower alkyl; R29 is hydrogen, lower alkyl, lower alkoxycarbonyl, lower alkanoyl, aroyl, perfluoro lower alkanoylamino, lower alkyl sulfonyl, lower alkylaminocarbonyl, arylaminocarbonyl, or R28 and R29 taken together from a 4, 5 or 6-membered saturated carbacyclic ring optionally containing one heteroatom selected from O, S, and N; with the carbon atoms in the ring being unsubstituted or substituted by lower alkyl or halogen; Q is â€”(CH2)fOâ€”, â€”(CH2)fSâ€”, â€”(CH2)fN(R27)â€”, or â€”(CH2)fâ€”, R27 is H, lower alkyl, aryl, lower alkanoyl, aroyl or lower alkoxycarbonyl; e is an integer from 0 to 4, and f is an integer from 0 to 3; and the dotted bond is optionally hydrogenated; or pharmaceutically acceptable salts and esters thereof.