Patent ID: 7244594
Filing Date: 2007-07-17
Classification: C12P

Abstract:
1. A method for the preparation of at least one 26-hydroxyepothilone of formula: where: Q′ is selected from the group consisting of G A Q n, m, and o are integers independently selected from the group consisting of zero and 1, where at least one of m or n or o is 1; W is O or NR X is selected from the group consisting of O, and H, OR M is O, S, NR B R R R R R the pharmaceutically-acceptable salts thereof and any hydrates, solvates, or geometric, optical and stereoisomers thereof; comprising the steps of: a) contacting at least one epothilone of formula IVa where: the pharmaceutically-acceptable salts thereof and any hydrates, solvates, or geometric, optical and stereoisomers thereof; with a microorganism or enzyme derived therefrom capable of selectively catalyzing the hydroxylation of said R 5 group to —CH 2 OH; and b) effecting said hydroxylation.