Patent ID: 6992060
Filing Date: 2006-01-31
Classification: A61K,A61P,Y10S

Abstract:
1. A method for treating a subject having insulin-insufficient diabetes, comprising: administering for a term of treatment which is shorter in duration than about one percent of an average lifespan of the subject species a dose of each of a gastrin 17 having a methionine substituted for leucine at amino acid position 15 relative to the amino acid sequence of wild type gastrin 17, and a recombinant human EGF1-53 having a deletion of two C-terminus amino acids at amino acid positions 52 and 53 and having a neutral amino acid substituted at amino acid position 51 relative to the amino acid sequence of wild type EGF1-53, the treatment resulting in a remission of the diabetes wherein the subject has increased blood insulin and decreased blood glucose; and repeating administering of said gastrin 17 and said EGF 1-53 at a time corresponding to about the end of the remission, thereby treating the subject having insulin-insufficient diabetes.