Patent ID: 6664285
Filing Date: 2003-12-16
Classification: A61K,A61P

Abstract:
A method for the treatment of human solid tumors and metastasis thereof comprising,administering a cell membrane penetrating indigoid bisindole derivative to a human in need thereof, wherein said human solid tumors and metastasis thereof are selected from carcinomas, melanomas, adenomas, sarcomas, lymphomas, neuroblastomas, teratomas, astrocytomas, glioblastomas, or mesotheliomas, and the indigoid bisindole derivative is selected from bis(3-phenylindol-2-yl), isoindigo or indirubin derivatives, the indirubin derivatives being represented by the following formula (I): wherein, X represents an oxygen atom or NOH, and when X represents an oxygen atom, R1 represents a hydrogen atom, a halogen atom, a â€”NO2 group, a methyl group, a sulfonamide group or SO2â€”NHâ€”CH2CH2â€”OH; and when X represents NOH, R1 represents a hydrogen atom or an iodide atom.