Patent ID: 8569302
Filing Date: 2013-10-29
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt or ester thereof, wherein: R each Q each R or R each R each R wherein, each substituted Q R wherein, each substituted R each Q heterocyclyl, —OH, —NR 21 R 22 , —C(O)OR 20 , —CN, —N 3 , —C(═NR 23 )NR 21 R 22 , —C(═NR 23 )OR 20 , —NR 20 C(═NR 23 )NR 21 R 22 , —NR 21 C(O)OR 20 , and —OC(O)NR 21 R 22 ; each R or R each R each R wherein, each substituted Q R wherein each substituted R each Q each R or R each R each R wherein, each substituted Q L is selected from the group consisting of —O—, —S—, —S(O)—, and —S(O) Het is an optionally substituted 3-12 membered heterocyclyl or optionally substituted 3-14 membered heteroaryl; wherein, each substituted Het is substituted with one or more Q each Q halogen, oxo, oxide, —NO 2 , —SR 40 , —S(O)R 40 , —S(O) 2 R 40 , —S(O) 2 NR 40 R 41 , —NR 40 C(O)R 41 , —NR 40 C(O)NR 41 R 42 , —NR 40 S(O)R 41 , —NR 40 S(O) 2 R 41 , —OP(O)R 41 R 42 , —P(O)OR 41 R 42 , —P(O)(OR 41 )OR 42 , —C(O)NR 41 R 42 , optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 6-12 arylalkyl, optionally substituted C 6-12 aryl, optionally substituted 3-14 membered heteroaryl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyloxy, optionally substituted C 2-6 alkynyloxy, optionally substituted C 3-6 cycloalkyloxy, optionally substituted C 6-12 aryloxy, optionally substituted 3-14 membered heteroaryloxy, optionally substituted 4-12 membered heterocyclyloxy, optionally substituted —C(O)C 1-6 alkyl, optionally substituted —C(O)C 2-6 alkenyl, optionally substituted —C(O)C 2-6 alkynyl, optionally substituted —C(O)C 3-6 cycloalkyl, optionally substituted —C(O)C 6-12 aryl, optionally substituted —C(O)-3-14 membered heteroaryl, optionally substituted —C(O)C 6-12 arylalkyl, optionally substituted 3-10 membered heterocyclyl, —OH, —NR 41 R 42 , —C(O)OR 40 , —CN, —N 3 , —C(═NR 43 )NR 41 R 42 , —C(═NR 43 )OR 40 , —NR 40 C(═NR 43 )NR 41 R 42 , —NR 41 C(O)OR 40 , and —OC(O)NR 41 R 42 ; each R or R each R each R wherein, each substituted Q each Q halogen, oxo, oxide, —NO 2 , —N(═O), —SR 50 , —S(O)R 50 , —S(O) 2 R 50 , —S(O) 2 NR 50 R 51 , —NR 50 C(O)R 51 , —NR 50 C(O)NR 51 R 52 , —NR 50 S(O)R 51 , —NR 50 S(O) 2 R 51 , —OP(O)R 51 R 52 , —P(O)R 51 R 52 , —P(O)OR 51 R 52 , —P(O)(OR 51 )OR 52 , —C(O)NR 51 R 52 , optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 6-12 arylalkyl, optionally substituted C 6-12 aryl, optionally substituted 3-14 membered heteroaryl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyloxy, optionally substituted C 2-6 alkynyloxy, optionally substituted C 3-6 cycloalkyloxy, optionally substituted C 6-12 aryloxy, optionally substituted 3-14 membered heteroaryloxy, optionally substituted 4-12 membered heterocyclyloxy, optionally substituted —C(O)C 1-6 alkyl, optionally substituted —C(O)C 2-6 alkenyl, optionally substituted —C(O)C 2-6 alkynyl, optionally substituted —C(O)C 3-6 cycloalkyl, optionally substituted —C(O)C 6-12 aryl, optionally substituted —C(O)-3-14 membered heteroaryl, optionally substituted —C(O)C 6-12 arylalkyl, optionally substituted 3-10 membered heterocyclyl, —OH, —NR 51 R 52 , —C(O)OR 50 , —CN, —N 3 , —C(═NR 53 )NR 51 R 52 , —C(═NR 53 )OR 50 , —NR 50 C(═NR 53 )NR 51 R 52 , —NR 51 C(O)OR 50 , and —OC(O)NR 51 R 52 ; each R or R each R each R wherein, each substituted Q each Q oxide, —NO 2 , —N(═O), —SR 60 , —S(O)R 60 , —S(O) 2 R 60 , —S(O) 2 NR 60 R 61 , —NR 60 C(O)R 61 , —NR 60 C(O)NR 61 R 62 , —NR 60 S(O)R 61 , —NR 60 S(O) 2 R 61 , —OP(O)R 61 R 62 , —P(O)R 61 R 62 , —P(O)OR 61 R 62 , —P(O)(OR 61 )OR 62 , —C(O)NR 61 R 62 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 6-12 arylalkyl, C 6-12 aryl, 3-14 membered heteroaryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 3-6 cycloalkyloxy, C 6-12 aryloxy, 3-14 membered heteroaryloxy, 4-12 membered heterocyclyloxy, —C(O)C 1-6 alkyl, —C(O)C 2-6 alkenyl, —C(O)C 2-6 alkynyl, —C(O)C 3-6 cycloalkyl, —C(O)C 1-6 haloalkyl, —C(O)C 6-12 aryl, —C(O)-3-14 membered heteroaryl, —C(O)C 6-12 arylalkyl, 3-10 membered heterocyclyl, —OH, —NR 61 R 62 , —C(O)OR 60 , —CN, —N 3 , —C(═NR 63 )NR 61 R 62 , —C(═NR 63 )OR 60 , —NR 60 C(═NR 63 )NR 61 R 62 , —NR 61 C(O)OR 60 , and —OC(O)NR 61 R 62 ; each R or R each R each R