Patent ID: 8278446
Filing Date: 2012-10-02
Classification: C07D

Abstract:
1. A process for preparing a compound of Formula (I) and an acid salt thereof: wherein L is selected from a bond, C Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-C R R wherein aryl-C wherein heterocyclyl-C R R wherein aryl, aryloxy, aryl-C wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from C comprising the steps of: Step 1. reacting a Compound 1a** (wherein Ra represents a halogen leaving group), a Compound A1 in an aqueous solvent and a catalytic amount of acid to provide a Compound A2 acid salt: Step 2. reacting the Compound A2 acid salt with a Compound A3 bis-acid salt (wherein the acid of the bis-acid salt is HRa) and a base to provide a Compound A4 acid salt, representative of a compound of Formula (I):