Patent ID: 6495559
Filing Date: 2002-12-17
Classification: A61P,C07D

Abstract:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein;V and W are independently selected from CH and N, provided that V and W cannot simultaneously be CH and that V and W cannot simultaneously be N; R1 is H, C1-3 alkyl, C1-3 alkoxy, F, or C; R2 is S(O)n R6, COR6 or CHO, wherein n is 0, 1 or 2; and R6 is N(R3)2 or C1-3 alkyl; R3 is independently H or C1-3 alkyl; Ar is aryl or heteroaryl; R4 and R5 are independently selected from: (1) hydrogen, (2) aryl, either unsubstituted or substituted with (a) halo (b) C1-3 alkoxy, (c)-N(C1-3 alkyl)2, (d) C2-4 alkanoyl, or (e) aryl; (3) nitro, (4) C1-5 alkyl, (5) C1-5 alkoxy, (6) hydroxy-C1-alkyl, (7) carboxy, (8) halo, (9) C1-5 alkythio, (10) C1-5 ethoxycarbonyl, (11) pyridylcarbonyl, (12) benzoyl, (13) phenyl-C1-3 alkoxy, (14) pyridyl, either unsubstituted or substituted with C1-3 alkyl or C1-3 alkoxy, (15) C3-6 cycloalkyl, (16) oxazolyl, (17) thiazolyl, (18) triazolyl or (19) phenoxy.