Patent ID: 6277634
Filing Date: 2001-08-21
Classification: A61K,C12N

Abstract:
A compound having the formula: ##STR11##3' (X).sub.n -(Seq. ID No. 51)-(T/U).sub.b --G--(X).sub.n -(Seq. ID No. 52)-(X).sub.n' 5'wherein each X represents a nucleotide which may be the same or different and may be modified in its sugar, base or phosphate;wherein each of A, C, G, U, and T represents a nucleotide which may be substituted or modified in its sugar, base or phosphate;wherein (T/U)--(T/U).sub.b --G represents T--(T).sub.b --G or U--(U).sub.b --G, with the proviso that b represents an integer which is 3, 4 or 5;wherein each of (X).sub.n and (X).sub.n', represents an oligonucleotide having a predetermined sequence which is capable of hybridizing with an RNA target sequence;wherein each of n and n' represents an integer which defines the number of nucleotides in the oligonucleotide;wherein each solid line represents a covalent bond between the nucleotides located on either side thereof; andwherein a represents an integer which defines a number of nucleotides with the proviso that a may be 0 or 1 and if 0, the A located 5' of (X).sub.a is bonded to the G located 3' of (X).sub.a.