Patent ID: 7078177
Filing Date: 2006-07-18
Classification: A61P,G01N

Abstract:
1. A method for identifying a compound that is able to bind to the rat or human MAS receptor, comprising: a) providing a cell or membrane from a cell transformed with a heterologous rat or human MAS receptor gene, said cell expressing the rat or human MAS receptor; b) incubating the cell or membrane with Dynorphin A or Dynorphin A-amide or Dynorphin A 1-13 in the presence and absence of a test compound; and c) determining binding of Dynorphin A or Dynorphin A-amide or Dynorphin A 1-13 to the cell or membrane, wherein a decrease in binding in the presence of the compound as compared with binding in the absence or the compound indicates that the compound is able to bind to the rat or human MAS receptor.