Patent ID: 6906197
Filing Date: 2005-06-14
Classification: C07B,C07C,C07D

Abstract:
1. A process for the preparation of an optically active amine, the process comprising the steps of: (A) reacting a ketone of following Formula (7) or (8): wherein R 5 is an unsubstituted or substituted aryl-lower group, with an optically active amine of following Formula (2): wherein R 3 is an unsubstituted or substituted aryl group; R 4 is an unsubstituted or substituted lower alkyl group; and C 1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield an optically active imine of following Formula (11) or (12): wherein R 3 , R 4 , R 5 , and C 1 have the same meanings as defined above; and (B) hydrogenating the optically active imine of Formula (11) or (12) in the presence of a catalyst to thereby yield an optically active amine of following Formula (9) or (10): wherein R 3 , R 4 , R 5 , and C 1 have the same meanings as defined above; and C 2 is an asymmetric carbon atom.