Patent ID: 6689792
Filing Date: 2004-02-10
Classification: C07D

Abstract:
A compound according to the formula (1): whereinR1 and R2 are taken together to form a fused ring at the 2,3- or 3,4- positions providing a benzodioxane group, or a 4- or 7-substituted indole group, or a 5- or 8-substituted quinoline group; the group formed by the fusion of R1 and R2 being taken together is further optionally substituted by from 1 to 3 groups selected from H, COOH or the C1 to C6 alkyl esters thereof, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, OR5, â€”C(O)NR6R7, nitro, amino, or CF3; R3 represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen; R4 represents a group selected from hydrogen, 1 to 6 carbon alkyl or R5; R5 is CH2Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, or CF3; R6 and R7 are independently selected from H or C1 to C6 alkyl; X is selected from the group consisting of C [[CHR4,]] and CR4; A is selected from the group consisting of N, NH, CH and CH2; and B is selected from the group consisting of &boxH;O, H and H2; such that the moiety in formula (1) represented by the formula: is selected from the group of: with the proviso that when R1 and R2 taken together with the ring to which they are attached form a 4- or 7-substituted indole, A is CH2 and B is &boxH;O or H2;or a pharmaceutically acceptable salt thereof.