Patent ID: 8440803
Filing Date: 2013-05-14
Classification: A61P,C07H,C12N

Abstract:
1. A gapped oligomeric compound comprising at least one tetrahydropyran nucleoside analog of the formula: wherein independently for each tetrahydropyran nucleoside analog of said formula: Bx is a heterocyclic base moiety; T wherein said gapped oligomeric compound is an antisense compound comprising a first region of from 1 to about 5 contiguous monomer subunits a second region of from 1 to about 5 contiguous monomer subunits and a third region located between the first and second region comprising from 6 to about 14 monomer subunits wherein each monomer subunit in the first and second region is, independently, a modified nucleoside and each monomer subunit in the third region is, independently, a nucleoside or a modified nucleoside other than the modified nucleosides in the first and second region wherein at least one modified nucleoside in the first and second region is a tetrahydropyran nucleoside analog of said formula.