Patent ID: 7345171
Filing Date: 2008-03-18
Classification: A61P,C07D

Abstract:
1. A method of making a crystalline isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, the method comprising: combining a solution of isethionic acid and a first solvent with a dispersion of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one and water to produce a first mixture; freeze-drying the first mixture to give an amorphous salt; mixing the amorphous salt with a second solvent to produce a second mixture that includes a crystalline isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, the second solvent being the same as or different than the first solvent; and optionally heating the second mixture, cooling the second mixture, or heating and cooling the second mixture.