Patent ID: 6288106
Filing Date: 2001-09-11
Classification: A61K,C07D

Abstract:
A method for the clinical management of a subject suffering from a condition selected from the group consisting of chronic essential hypertension, cerebral vascular disease, chronic open angle glaucoma, hearing loss, macular degeneration, lenticular cataract, insulin resistance, diabetic retinopathy, coronary artery disease, Parkinson's disease, Alzheimer's disease, neurodegenerative disease, and vasoconstriction, said method comprising administering to said subject an amount effective in reducing said condition of a metal .alpha.-lipoic acid complex of the formula[A]M XwhereinA is .alpha.-lipoic acid,M is a metal ion selected from the group consisting of Mg.sup.+2, Cu.sup.+2, and Zn.sup.+2, andX is an anion selected from the group consisting of hydroxide, halide, acetate, ascorbate and bis-ascorbate.