Patent ID: 6953657
Filing Date: 2005-10-11
Classification: A61K,C07K

Abstract:
1. A method for identifying a compound which modulates the interaction between CARD-7 and CARD-5, the method comprising: a) contacting, in the presence of a test compound, a first polypeptide comprising amino acids 1335-1429 of SEQ ID NO:2 with a second polypeptide comprising amino acids 111-181 of SEQ 8; b) measuring the binding of the first polypeptide to the second polypeptide in the presence of the test compound; and c) identifying the test compound as a compound which modulates the interaction between CARD-7 and CARD-5 when the binding of the first polypeptide to the second polypeptide is increased or decreased in the presence of the test compound compared the binding of the first polypeptide to the second polypeptide in the absence of the test compound.