Patent ID: 6395724
Filing Date: 2002-05-28
Classification: A61K,A61P,C07C,C07D,C07H,C12Q,C40B,G01N

Abstract:
A compound of formula I:(L)p(X)qâ€ƒâ€ƒI wherein each L is a ligand independently selected from formula IA, IB or IC: â€ƒwherein ring A, together with the atoms to which it is attached, forms a cyclobut-2-en-1-one, thiazole, isothiazole, thiadiazole, oxazole, isoxazole, 5(H)-furanone, benzene, pyridine, imidazopyridine, imidazothiazole or thiazolotriazole ring; ring B, together with the atoms to which it is attached, forms a pyrazole ring; ring C, together with the atoms to which it is attached, forms an imidazole ring; R1 is selected from the group consisting of â€”SO2CH3, â€”SO2NH2, â€”SO2NHC(O)CF3, â€”SO2(NH)NH2 and â€”SO(NH)NHC(O)CF3; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkoxycarbonyl, amino, substituted amino, azido, carboxyl, cyano, cycloalkyl, substituted cycloalkyl, halo, hydroxyl, nitro, thioalkoxy and substituted thioalkoxy; R3 is a covalent bond linking the ligand to a linker; and &agr; is an integer from 0 to 3; and each X is independently a linker of the formula: â€”Xaâ€”Zâ€”(Yaâ€”Z)mâ€”Ybâ€”Zâ€”Xaâ€”â€ƒwherein m is an integer of from 0 to 20; Xa at each separate occurrence is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”NRâ€”, â€”C(O)â€”, â€”C(O)Oâ€”, â€”C(O)NRâ€”, â€”C(S)â€”, â€”C(S)Oâ€”, â€”C(S)NRâ€” and a covalent bond where R is as defined below; Z is at each separate occurrence is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cycloalkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, cycloalkenylene, substituted cycloalkenylene, arylene, heteroarylene, heterocyclene, and a covalent bond; Ya and Yb at each separate occurrence are selected from the group consisting of â€”C(O)NRâ€²â€”, â€”NRâ€²C(O)â€”, â€”NRâ€²C(O)NRâ€²â€”, â€”C(&boxH;NRâ€²)â€”NRâ€²â€”, â€”NRâ€²â€”C(&boxH;NRâ€²)â€”, â€”NRâ€²â€”C(O)â€”Oâ€”, â€”P(O)(ORâ€²)â€”Oâ€”, â€”S(O)nCRâ€²Râ€³â€”, â€”S(O)nâ€”NRâ€²â€”, â€”Sâ€”Sâ€” and a covalent bond; where n is 0, 1 or 2; R, Râ€² and Râ€³ at each separate occurrence are selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl and heterocyclic; p is an integer of from 2 to 10; q is an integer of from 1 to 20, provided that q is less than p; and pharmaceutically-acceptable salts thereof.