Patent ID: 8071635
Filing Date: 2011-12-06
Classification: A61P,C07D

Abstract:
1. A method of activating alpha 2B or alpha 2C adrenergic receptors in a mammal in need of such activation by administering to the mammal a pharmaceutical composition containing a therapeutically effective dose of an alpha 2B or alpha 2C receptor agonist compound having the formula: wherein the variable Y in the ring is optional and represents a heteroatom selected from N, O and S with the proviso that the N atom is trivalent, and the O or S atoms are divalent; k is an integer having the values of 0 or 1; n is an integer having the values 1 or 2; p is an integer having the values 0, 1 or 2; X is O or S; the dashed lines represent a bond, or absence of bond with the proviso that only one double bond is present in the ring and that two adjoining dashed lines do not both represent a bond; R or said R R R R R m is an integer having the values 0 to 3; R R R or a pharmaceutically acceptable salt thereof with the proviso that the formula does not include the compounds shown below by structural formula or their pharmaceutically acceptable salts where an asterisk indicates an asymmetrical carbon, wherein said administering activates the alpha