Patent ID: 9052317
Filing Date: 2015-06-09
Classification: A61K,A61P,G01N

Abstract:
1. A composition, for the treatment of conditions associated with a mucosal immune response comprising: a chimeric molecule that specifically binds the APN receptor on mucosal epithelial cells and induces clathrin-mediated transcytosis comprising a target molecule that specifically binds APN on mucosal epithelial cells; wherein said APN specific target molecule is an anti-APN antibody or fragment thereof comprising from about 5 to 95% by weight of said anti-APN antibody and from about 1 to 95% by weight of a heterologous antigen or therapeutic molecule, wherein said APN specific target molecule binds said APN receptor through the α2-3, α2-6, α2-8, or α2-9 linked sialic acids bound thereto.