Patent ID: 8986714
Filing Date: 2015-03-24
Classification: A61K,A61P,Y02A

Abstract:
1. A formulation adapted for the prophylactic treatment of neuropathology caused by trauma to a subject, or for the amelioration of the effects caused by trauma to a subject, the formulation comprising four biologically active compounds in amounts that are pharmaceutically effective for each compound, respectively, when administered in combination with the other three biologically active compounds, the four compounds comprising a pharmaceutically effective amount of: A. at least one biologically active compound from the group comprising anticonvulsants, wherein the anticonvulsant is at least one form of gabapentin, wherein the gabapentin is provided in a dosage range of from about 5.0 mg to about 9,600 mg; B. at least one biologically active compound from the group comprising neurosteroids, wherein the neurosteroid is at least one form of progesterone, wherein the progesterone is provided in a dosage range of from about 0.05 mg to about 1,200 mg; C. at least one biologically active compound from the group comprising NK-1 receptor antagonists, wherein the NK-1 receptor antagonist is at least one form of aprepitant, wherein the aprepitant is provided in a dosage range of from about .05 mg to about 750 mg; and D. at least one biologically active compound from the group comprising lithium-containing compounds, wherein the lithium-containing compound is at least one form of lithium carbonate, wherein the lithium carbonate is provided in a dosage range of from about 0.5 mg to about 3,600 mg; wherein the formulation comprises a single dosage unit; and wherein the formulation is in a form and a dosage with respect to each of its components such that it is adapted and arranged for administration to a mammal in need thereof, such that the development, or the risk of development, of neuropathology caused by trauma or effects caused by trauma are reduced, lessened, attenuated or prophylactically treated.