Patent ID: 6613791
Filing Date: 2003-09-02
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I whereinR1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; Y is >CHâ€”CH2â€” or >C&boxH;CHâ€” wherein only the underscored atom participates in the ring system; X is â€”CH2CH2â€”, â€”CH2â€”(C&boxH;O)â€”, â€”(C&boxH;O)â€”CH2â€”, or â€”CH&boxH;CHâ€”; r is 1, 2 or 3; and Z is wherein R3 is â€”(CH2)mOH or â€”COR4 wherein m is 0, 1, 2, 3, 4, 5 or 6, and R4 is â€”OH, â€”NH2, â€”NHOH or C1-6-alkoxy, or a pharmaceutically acceptable salt thereof.