Patent ID: 6627653
Filing Date: 2003-09-30
Classification: A61K,A61P

Abstract:
A method for treating depression in a subject afflicted with such condition comprising administering to the subject a therapeutically effective amount of a compound of the formula I whereinX is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): whereinR6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring, alone or in combination with one or more compounds selected from the group consisting of mono-amine oxidase inhibitors, tricyclics, serotonin reuptake inhibitors, serotonin noradrenergic reuptake inhibitors, noradrenergic and specific serotonergic agents, noradrenaline reuptake inhibitor, natural products, dietary supplements, neuropeptides, compounds targeting neuropeptide receptors and hormone, wherein said depression is selected from the group consisting of treatment-retractory depression, resistant depression, anxious depression and dysthymia.