Patent ID: 7160542
Filing Date: 2007-01-09
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting TNFα in a human patient, wherein said human patient has psoriasis, comprising administering to the human patient an effective TNFα-inhibiting amount of an anti-TNFα antibody or antigen-binding fragment thereof, said antibody comprising a human IgG4 constant region, wherein the antigen-binding fragment is a Fab′ fragment, and wherein said anti-TNFα antibody or antigen-binding fragment thereof (i) competitively inhibits binding of A2 (ATCC Accession No. PTA-7045) to human TNFα, and (ii) binds to a neutralizing epitope of human TNFα with an affinity of at least 1×10 8 liter/mole, measured as an association constant (Ka), as determined by Scatchard analysis.