Patent ID: 7625915
Filing Date: 2009-12-01
Classification: A61P,C07D

Abstract:
1. A method for treating colon cancer comprising administering an effective amount of a compound of formula I, including pharmaceutically acceptable salts thereof, to a host in need thereof: wherein A is wherein R1 is C 3 -C10 alkyl, C3-C 10 cycloalkyl, up to per-halosubstituted C 1 -C 10 alkyl or up to per-halosubstituted C 3 -C 10 cycloalkyl; B is phenyl substituted by one or more substituents which are independently halogen, up to per-halosubstitution, or X wherein n is 0-3 and each X is independently —CN, CO where X is a substituted group, it is substituted by one or more substituents which are independently —CN, —CO wherein R wherein Y is —O—, —S—, or —(CH m=1-3, and Ar is phenyl or pyridinyl which is optionally substituted by halogen up to per-halosubstitution and optionally substituted by Z n1 , wherein n1 is 0 to 3 and each Z is independently —CN, —C(O)R 5 , —CO 2 R 5 , —C(O)NR 5 R 5′ , —C(O)NR 5 , —NO 2 , —OR 5 , —SR 5 , —NR 5 R 5′ , —NR 5 C(O)OR 5′ , —NR 5 C(O)R 5′ , C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, C6-C14 aryl, C 3 -C 13 heteroaryl, C 7 -C 24 alkaryl, C4-C 23 alkheteroaryl, substituted C 1 -C 10 alkyl, substituted C 3 -C 10 cycloalkyl, substituted C 7 -C 24 alkaryl or substituted C 4 -C 23 alkheteroaryl; wherein if Z is a substituted group, it is substituted by the one or more substituents which is independently —CN, —CO wherein R wherein if R wherein n=0-3 and each V is —CN, —CO where V is a substituted group, it is substituted by one or more substituents which are independently halogen, up to per-halosubstitution, —CN, —CO wherein R