Patent ID: 6750214
Filing Date: 2004-06-15
Classification: A61P,C07D

Abstract:
A compound of formula I, whereinR1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents C1 alkoxy; R3 represents one or more groups independently selected from H, halogen, C1-4 alkoxy and CF3; wherein R2 and one R3 group together represent â€”OCH2â€”, the methylene group being attached to the ortho-position of the pendant phenyl ring; R4 represents a group having the formula II, III, IV, V, or VI, Y represents O, CH2, SO2, NR5 or CHF; and R5 represents H or C1-4 alkyl; X represents N; and L is absent; or represents a cyclic group of formula Ia, in which N is attached to the 2-position of the quinazoline ring; A is absent or represents CO or SO2; Z represents CH or N; m represents 1 or 2, and in addition, when Z represents CH, it may represent 0; and n represents 1, 2 or 3, provided that the sum of m and n is 2, 3, 4 or 5; or represents a chain of formula Ib, in which N is attached to the 2-position of the quinazoline ring; Aâ€² and Zâ€² have the same significance as A and Z above, respectively; R6 and R7 independently represent H or C1-4 alkyl; and p represents 1, 2 or 3; or a pharmaceutically acceptable salt thereof.