Patent ID: 6562817
Filing Date: 2003-05-13
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula (I):â€‰wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5- or 6-membered heterocycle which may fuse with benzene ring,W1, W2 and/or W3 represents a single bond when A ring, B ring and/or C ring is optionally substituted 5-membered heterocycle, X is â€”Oâ€”, â€”CH2â€”, â€”NR1â€” wherein R1 is hydrogen, optionally substituted lower alkyl, lower alkenyl, lower alkylcarbonyl or optionally substituted lower alkoxycarbonyl or â€”S(O)pâ€” wherein p is an integer of 0 to 2, Y is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted RC(O) wherein R is hydrogen, alkyl, alkenyl, cycloalkyl or aryl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted sulfamoyl, optionally substituted amino, optionally substituted aryl or optionally substituted 5- or 6-membered heterocycle, Y may be optionally substituted lower alkoxy when X is â€”CH2â€”, Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is â€”Oâ€” or â€”NR1â€”, one of V1 and V2 is a single bond and the other is a single bond, an â€”Oâ€” bond, an â€”NHâ€” bond, an â€”OCH2â€” bond, a â€”CH2Oâ€” bond, a â€”CH&boxH;CHâ€” bond, a â€”Câ‰¡Câ€” bond, a â€”CH(OR2)â€” bond, wherein R2 is hydrogen or lower alkyl, a â€”COâ€” bond, or an â€”NHCHR3â€” bond, wherein R3 is hydrogen or hydroxy, and at least one of A ring, B ring and C ring is optionally substituted aromatic carbocycle and at least another one is optionally substituted 5- or 6-membered heterocycle which may fuse with benzene ring when both of V1 and V2 are single bonds, excluding (i) a compound wherein B ring is optionally substituted imidazole ring, optionally substituted furan ring, optionally substituted thiophene ring, optionally substituted pyrrole ring, optionally substituted oxazole ring, or optionally substituted thiazole ring, (ii) a compound wherein both of A ring and C ring are optionally substituted pyrazole ring and â€”Xâ€”Y is methyl, (iii) a compound wherein one of A ring and C ring is optionally substituted oxadiazole ring or optionally substituted tetrazole ring, and provided that (iv) when at least one of A ring, B ring and c ring is optionally pyrimidine ring or when all of A ring, B ring and C ring are optionally substituted benzene ring, (iv-1) C ring is substituted with Xâ€²â€”Yâ€² at paraposition of V2 wherein Xâ€² is the same as X and Yâ€² is the same as Yâ€² and (iv-2) at least one of â€”Xâ€”Y and â€”Xâ€²â€”Yâ€² is other than unsubstituted lower alkyl, unsubstituted lower alkoxy, unsubstituted alkanoyloxy and unsubstituted lower alkylamino, salt or hydrate thereof.