Patent ID: 6811988
Filing Date: 2004-11-02
Classification: C07K,G01N

Abstract:
A method for detecting at least one antibody directed against a modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, comprising:a) providing; i) a sample suspected of containing at least one antibody directed against a modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, and ii) an isolated and modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct, and iii) a detection antibody; b) contacting said sample with said modified &bgr;-amyloid peptide, under conditions such that said antibody directed against a modified &bgr;-amyloid peptide comprising at least one malondialdehyde adduct binds to said modified &bgr;-amyloid peptide to form an antigen-antibody complex; c) contacting said antigen-antibody complex with said detection antibody, under conditions such that said detection antibody binds to said complex; and d) detecting said binding of said detection antibody to said antigen-antibody complex.