Patent ID: 6642238
Filing Date: 2003-11-04
Classification: A61K,C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein:W is NHC(&boxH;S)R1, R1 is (a) H, (b) NH2, (c) NHC1-4 alkyl, (d) C2-4 alkenyl, (e) OC1-4 alkyl, (f) SC1-4 alkyl, (g) (CH2)n-C3-6 cycloalkyl, or (h) C1-4 alkyl, optionally substituted with 1-3 F, 1-2 Cl or CN; R2 and R3 are independently H, F, Cl or C1-2 alkyl; R4 is (a) â€”C(&boxH;O)â€”CH2S(O)nâ€”CH3, (b) â€”C(&boxH;S)C1-4 alkyl, (c) â€”C(&boxH;O)â€”(CH2)mâ€”C(&boxH;O)â€”CH3, (d) â€”C(&boxH;O)â€”CH2â€”Oâ€”R10, or (e) â€”CN; R10 is â€”CO2â€”(CH2)2â€”OCH3, or â€”C(&boxH;O)â€”NHC1-4alkyl; n is 0, 1 or 2; and m is 0 or 1.