Patent ID: 6492375
Filing Date: 2002-12-10
Classification: A61K,C07D,C40B

Abstract:
A method to treat conditions associated with abnormal N-type calcium channel activity in a subject which method comprises administering to a subject in need of such treatment a compound of the formula or the salts thereof,wherein, each of Z1 and Z2 is independently N or CH, but one of Z1 and Z2 must be N; wherein n1 is 1 and n2 is 0 or 1; X1 and X2 are straight chain linkers; Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic single rings, and Cy represents one or two substituted or unsubstituted aliphatic cyclic or heterocyclic single rings, or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic single ring and one substituted or unsubstituted aromatic or heteroaromatic single ring; each of Ya and Yb is two substituted or unsubstituted aromatic or heteroaromatic single rings, or can be two substituted or unsubstituted aliphatic cyclic or heterocyclic single rings or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic single ring and one substituted or unsubstituted aromatic or heteroaromatic single ring; with the proviso that said rings of Ya cannot both be phenyl when Ar represents a single phenyl ring and X1 contains less than 5C; and with the proviso that formula (1b) must contain at least one aromatic or heteroaromatic ring; 11 is 0 or 1; R1 is substituted or unsubstituted alkyl (1-6C), substituted or unsubstituted aryl (6-10C) or substituted or unsubstituted arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or may independently be halo, OR, SR, NR2, OOCR, NROCR, COR, COOR, CONR2, CF3, OCF3, CN or NO2, wherein R is H or alkyl (1-6C).