Patent ID: 6147215
Filing Date: 2000-11-14
Classification: C07D

Abstract:
A process for producing 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride represented by the following formula (4): ##STR2## or 1-chlorocarbonyl-4-piperidinopiperidine represented by the following formula (5): ##STR3## which comprises reacting 4-piperidinopiperidine represented by the following formula (1): ##STR4## with a trialkylsilyl halide to obtain a 4-piperidinopiperidinyl trialkylsilyl represented by the following formula (2): ##STR5## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and each independently represents a linear or branched C.sub.1-6 alkyl group; reacting the resulting compound with a carbon dioxide gas to obtain a 4-piperidinopiperidinyl trialkylsilyl carbamate derivative represented by the following formula (3): ##STR6## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meanings as defined above; reacting the derivative with one or more substances selected from thionyl chloride, phosphorus trichloride, phosphorus pentachloride, oxalyl chloride and phosphoryl trichloride; and optionally reacting with a strong base.