Patent ID: 6034086
Filing Date: 2000-03-07
Classification: A61P,C07D

Abstract:
A 8-trifluoromethylquinolinecarboxylic acid compound represented by the following formula (I): ##STR17## wherein R.sup.1 represents a C.sub.1 to C.sub.4 alkyl group, a halogeno-C.sub.1 to C.sub.4 alkyl group or a C.sub.3 to C.sub.6 cycloalkyl group,R.sup.2 represents a phenyl group which is unsubstituted or substituted by a substituent R.sup.0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from the group consisting of N, O and S, which is unsubstituted or substituted by said R.sup.0, or an aromatic heterocyclic fused ring group in which said heteromonocyclic ring group and a benzene ring are fused, which is unsubstituted or substituted by said R.sup.0,said R.sup.0 represents a halogen, a C.sub.1 to C.sub.4 alkyl, a fluorine-substituted C.sub.1 to C.sub.4 alkyl, a C.sub.1 to C.sub.4 alkoxy or a C.sub.1 to C.sub.4 alkylthio,R.sup.3 represents hydrogen or a C.sub.1 to C.sub.4 alkyl group, andm represents an integer of 2,provided that a compound wherein R.sup.1 is an ethyl group, R.sup.2 is a trifluoromethyl group and R.sup.3 is a 2-pyrimidiniyl group is excluded;or a pharmaceutically acceptable salt or ester thereof.