Patent ID: 7750011
Filing Date: 2010-07-06
Classification: A61P,C07D

Abstract:
1. A (R,R) or (S,S) 2,5-diaza-bicyclo[2.2.1]heptane aryl compound represented by Formula I or an enantiomer or a mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, wherein R represents hydrogen, alkyl, cycloalkyl or cycloalkyl-alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic group, which carbocyclic or heterocyclic groups are optionally substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy, alkoxy, cyanoalkyl, halo, trihaloalkyl, trihaloalkoxy, cyano, amino and nitro; B represents a phenyl or naphthyl group, a 5-6 membered aromatic monocyclic heterocyclic group, or an aromatic bicyclic heterocyclic group; which aromatic groups may optionally be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, hydroxy, alkoxy, cyanoalkyl, halo, trihaloalkyl, trihaloalkoxy, cyano, amino, nitro, and —NH(CO)R′; wherein R′ represents hydrogen, alkyl or cycloalkyl; and L represents —O—, —S—, —S—CH