Patent ID: 6555570
Filing Date: 2003-04-29
Classification: A61K,A61P,B41J,C07C,C07D,C07K

Abstract:
A compound of formula I whereinR1 is hydrogen or C1-6-alkyl optionally substituted with aryl; R2 is C1-6-alkyl optionally substituted with aryl; a and b are independently 1 or 2; G is â€”Oâ€”(CH2)kâ€”R27, J is â€”Oâ€”(CH2)lâ€”R32, â€ƒwherein R27, R28, R29, R30, R31, R32, R33, R34, R35 and R36 are hydrogen, halogen, aryl ,C1-6-alkyl or C1-6-alkoxy; k and l are independently 0, 1 or 2; D is R7â€”NHâ€”(CR8R9)pâˆ’(CH2)mâ€”Mâ€”(CHR10)oâ€”(CH2)nâ€”â€ƒwherein R7, R8, R9 and R10 are independently hydrogen or C1-6 alkyl optionally substituted with halogen, amino, hydroxyl or aryl; n and m are independently 0, 1, 2, or 3; o and p are independently 0 or 1; M is â€”CR11&boxH;CR11aâ€”, aryl, â€”Oâ€”, or â€”Sâ€”; R11 and R11a are independently hydrogen or C1-6-alkyl optionally substituted with aryl, E is â€”CONR12R13, â€ƒwherein R12 is hydrogen or C1-6-alkyl optionally substituted with halogen, â€”CONR22R23, â€”N(R22)R23, â€”CF3, hydroxyl, C1-6-alkoxy, C1-6-alkoxy carbonyl, C1-6-alkylcarbonyloxy or aryl; R13 is â€ƒwherein Q is â€”CH< or â€”NK and L are independently â€”CH2â€”, â€”COâ€”, â€”Oâ€”, â€”Sâ€”, â€”NR26â€” or a valence bond, where R26 is hydrogen or C1-6 alkyl, with the proviso that when Q is â€”CH26â€”; t and u are independently 0, 1, 2, 3 or 4; R22 and R23 are independently hydrogen or C1-6 alkyl; v and w are independently 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.