Patent ID: 6521656
Filing Date: 2003-02-18
Classification: A61K,A61P,C07D

Abstract:
A method for treating infertility or treating male sterility comprising:selecting a subject in need thereof, contacting sperm in said subject with an amount of an adenosine A1 antagonist effective for inducing a sperm acrosomal reaction, and contacting said sperm with an ovum, wherein said adenosine A1 antagonist is a pyrazolopyridine compound of the following general formula or a salt thereof: â€ƒwherein R1 is lower alkyl, aryl which may have one or more suitable substituent(s) or a heterocyclic group; R2 is a group of the formula: â€ƒwherein R4 is protected amino or hydroxy, and R5 is hydrogen or lower alkyl; cyano; a group of the formula: â€”Aâ€”R6, wherein R6 is an acyl group, and A is a lower aliphatic hydrocarbon group which may have one or more suitable substituent(s); an amidated carboxyl; an unsaturated heterocyclic group which may have one or more suitable substituent(s); amino; or a protected amino; and R3 is hydrogen, lower alkyl, lower alkoxy, or halogen.