Patent ID: 6756215
Filing Date: 2004-06-29
Classification: C07K

Abstract:
A TGF-&bgr; family fusion protein, comprising:a N-terminal region consisting of an amino acid sequence of a pro-region (latency associated peptide) of a TGF-&bgr;1, a functionalizing peptide tag of no more than about 100 amino acids; and an amino acid sequence consisting of the mature portion of the TGF-&bgr;1; wherein the functionalizing peptide tag is inserted between a pair of adjacent residues between about residues 1 and 22 of the mature portion of the TGF-&bgr;1; and wherein the portion of the fusion protein comprising the mature portion of the TGF-&bgr;1 and the functionalized peptide tag has TGF-&bgr;1 activity that is reduced by no more than 50% as compared to the mature TGF-&bgr;1 alone.