Patent ID: 6048527
Filing Date: 2000-04-11
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
An isolated antibody directed against an N-propionylated Neisseria meningitidis serogroup B capsular polysaccharide, wherein said antibody is not autoreactive or minimally autoreactive as determined by measuring the ability of said antibody to react with human neuroblastoma cell line CHP-134, wherein the antibody is produced using an N-propionylated Neisseria meningitidis serogroup B capsular polysaccharide-protein conjugate having a saccharide-to-protein ratio ranging from 0.10 to 0.25 by weight, wherein the antibody is monoclonal antibody SEAM-2 produced by the hybridoma having ATCC Accession number CRL-12380.