Patent ID: 6322817
Filing Date: 2001-11-27
Classification: A61K,Y10S

Abstract:
A process for preparing a pharmaceutical composition of paclitaxel, its derivatives or analogs entrapped into nanoparticles of co-polymeric micelles comprising the steps of:a) dissolving at least one type of amphiphilic monomer selected from the group consisting of vinylpyrrolidone, acrylic acid, alkyl acrylates having a chain length of C.sub.3 to C.sub.6 functionalized polyethylene glycol of a molecular weight of 2000 to 6000, N-alkylacrylamide having a chain length of C.sub.3 to C.sub.6, and alkylcyanoacrylate having a chain length of C.sub.3 to C.sub.6, in an aqueous medium to obtain micelles;b) polymerizing the micelles by adding an aqueous solution of cross-linking agent;c) polymerizing the solution in the presence of an inert gas at 20.degree. C. to 80.degree. C. until the polymerization of micelles is complete;d) dialysing the solution of nanoparticles of polymerized micelles to remove toxic monomer and other unreacted materials, ande) adding an alcoholic solution of paclitaxel, its derivatives or analogs to the nanoparticles of polymerized micelles.