Patent ID: 8039257
Filing Date: 2011-10-18
Classification: A61K,A61P,C07K

Abstract:
1. A method for providing a tissue or organ resistant to complement-dependent cytotoxicity mediated by preformed antibodies reactive with donor antigen in a sensitized recipient mammal, comprising the steps of: (i) infusing a first donor mammal at least one time with sub-lethal levels of bone marrow from a sensitized recipient mammal, (ii) administering a tissue or organ from a second donor mammal to the first donor mammal; (iii) allowing prolonged exposure of the first donor mammal to the bone marrow, (iv) harvesting the tissue or organ of the second donor mammal from the first donor mammal; and (v) determining that the tissue or organ of the second donor mammal is resistant to complement-dependent cytotoxicity mediated by preformed antibodies of the sensitized recipient mammal reactive with donor antigen, wherein the method does not include administering an accommodation-inducing factor other than bone marrow; and wherein the first donor mammal is a non-human pre-immune fetal donor mammal.