Patent ID: 6235755
Filing Date: 2001-05-22
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of Formula XII, ##STR32##and pharmaceutically acceptable addition salts thereof, whereinn=0 or 1;A and B are --CH.sub.2 -- or --CH(R.sup.10 --, where R.sup.10 is hydrogen, hydroxy, amino, amino substituted with one or more substituents, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyl substituted with one or more substituents, C.sub.1 -C.sub.6 alkoxycarbonyl, cyano, C.sub.1 -C.sub.6 aminoalkyl, or --(CH.sub.2).sub.s NR.sup.6 R.sup.7, where s is 1-6 and R.sup.6 and R.sup.7 are as defined below;R.sup.1 is carbazolyl or carbazolyl substituted with one or more substituents defined below;R.sup.5 is pyran, chromene, or benzofuran, or R.sup.5 is pyran, chromene, or bensofuran substituted with one or more substituent's defined below;R.sup.2 is hydrogen, or straight or branched C.sub.1 -C.sub.6 alkyl; andthe substituents are independently(a) halogen, cyano, oxo, carboxy, formyl, nitro, amino, amidino, guanidino, C.sub.1-C.sub.5 alkyl or alkenyl or arylalkyl imino, carbamoyl, azido, carboxamido, mercapto, hydroxy, hydroxyalkyl, alkylaryl, arylalkyl, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkenyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkoxycarbonyl, aryloxycarbonyl, C.sub.2 -C.sub.8 acyl, C.sub.1 -C.sub.8 alkylthio, arylalkylthio, arylthio, C.sub.1 -C.sub.8 alkylsulfinyl, arylalkylsulfinyl, arylsulfinyl, C.sub.1 -C.sub.8 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, C.sub.1 -C.sub.6 N-alkyl carbamoyl, C.sub.2 -C.sub.15 N,N-dialkylcarbamoyl, C.sub.3 -C.sub.7 cycloalkyl, aroyl, aryloxy, arylalkyl ether, aryl; or(b) NR.sup.6 R.sup.7, where R.sup.6 and R.sup.7 are each independently hydrogen, cyano, oxo, carboxamido, amidino, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.3 alkylaryl, aryl-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkenyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkoxycarbonyl, aryloxycarbonyl, aryl-C.sub.1 -C.sub.3 alkoxycarbonyl, C.sub.2 -C.sub.8 acyl, C.sub.1 -C.sub.8 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, aroyl, aryl or(c) --(CH.sub.2).sub.s NR.sup.6 R.sup.7 where s is 1-6 and R.sup.6 and R.sup.7 are as defined in (b).