Patent ID: 6538144
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
A compound of formula (I) in which the indicated radicals have the following meanings:R(1) is chosen from among 1. (C1-C5)-alkyl, unsubstituted or substituted by a radical chosen from among NH2, halogen, Oâ€”(C1-C3)-alkyl, COâ€”Oâ€”(C1-C3)-alkyl and CO2H; 2. (C3-C8)-cycloalkyl; 3. (C1-C3)-alkyl-(C3-C8)-cycloalkyl; 4. (C6-C10)-aryl, unsubstituted or substituted by a radical chosen from halogen and Oâ€”(C1-C3)-alkyl; 5. (C1-C3)-alkyl-(C6-C10)-aryl, where the aryl radical is unsubstituted or substituted by a radical chosen from halogen and Oâ€”(C1-C3)-alkyl; 6. (C3-C5)-heteroaryl; and 7. (C1-C3)-alkyl-(C1-C5)-heteroaryl; R(2) is chosen from among 1. hydrogen; 2. (C1-C6)-alkyl, unsubstituted or substituted by a radical chosen from halogen and Oâ€”(C1-C3)-alkyl; 3. (C3-C8)-cycloalkyl; 4. (C1-C3)-alkyl-(C3-C8)-cycloalkyl; 5. (C6-C10)-aryl, unsubstituted or substituted by a radical chosen from among halogen, Oâ€”(C1-C3)-alkyl and COâ€”Oâ€”(C1-C3)-alkyl; and 6. (C1-C3)-alkyl-(C6-C10)-aryl, unsubstituted or substituted by a radical chosen from halogen and Oâ€”(C1-C3)-alkyl; R(3) is chosen from among 1. hydrogen; 2. COOH; and 3. COOâ€”(C1-C4)-alkyl; R(4) is chosen from among 1. hydrogen; 2. halogen; and 3. (C1-C4)-alkyl; R(5) is chosen from 1. hydrogen, and 2. (C1-C6)-alkyl; R(6) is chosen from among 1. hydrogen; 2. (C1-C6)-alkyl; 3. (C1-C3)-alkyl-(C3-C8)-cycloalkyl; and 4. (C2-C6)-alkenyl; X is chosen from 1. oxygen, and 2. NH; in all the stereoisomeric forms thereof, and mixtures thereof in all ratios, and the physiologically tolerated salts thereof.