Patent ID: 8658433
Filing Date: 2014-02-25
Classification: A61K,A61P,B82Y,C09B,Y10S

Abstract:
1. A compound of the formula for use in a medical phototherapeutic procedure, the compound used to cause at least one of necrosis or apoptosis of a target tissue, wherein: DYE is a photoactive type 2 photodynamic therapy (PDT) agent that may further comprise a photoactive diagnostic agent, a photoactive type 1 phototherapeutic agent, another photoactive type 2 PDT agent, or a combination thereof wherein said type 2 PDT agent operates through a type 2 mechanism requiring formation of singlet oxygen for causing tissue damage; Y is a photoactive type 1 phototherapeutic agent that may further comprise another photoactive type 1 phototherapeutic agent, a photoactive type 2 PDT agent, or a combination thereof wherein said type 1 phototherapeutic agent operates through a type 1 mechanism, does not require oxygen for tissue damage and comprises azide or sulfenate moities; E is a targeting component for targeting the compound to an anatomical and/or physiological site of a patient; L is a linking component for linking E to DYE where L is selected from the group consisting of —(CH X is a linking component for linking DYE to Y where X is selected from the group consisting of —(CH