Patent ID: 6576263
Filing Date: 2003-06-10
Classification: A61K,A61P,C08G

Abstract:
A preformed object for delivering an active agent to a subject, the preformed object being self-supporting and at least partially desolvated crosslinked protein having a crosslinking agent of the formula:Iâ€”(â€”Xâ€”LMâ€”G)n wherein: X is a difunctional polyoxyethylene chain portion or a bond; LM is a difunctional linking moiety represented by the formulas â€”C(O)â€”, â€”(CH2)bC(O)â€” where b is an integer from 1 to 5, â€”C(O)â€”(CH2) Câ€”(O)â€” where c is an integer from 2 to 10 and where the aliphatic portion of the radical may be saturated or unsaturated, â€”C(O)â€”Oâ€”(CH2)dâ€”Oâ€”C(O)â€” where d is an integer from 2 to 10, or an oligomeric diradical represented by the formulas â€”Râ€”C(O)â€”, â€”Râ€”C(O)â€”(CH2)câ€”C(O)â€”, or â€”Râ€”C(O)â€”Oâ€”(CH2)dâ€”Oâ€”C(O)â€” where c is an integer from 2 to 10, d is an integer from 2 to 10, and R is a polymer or copolymer having 1 to 10 monomeric lactide, glycolide, trimethylene carbonate, caprolactone or p-dioxanone fragments; G is a leaving group selected from the group of N-oxysuccinimidyl, N-oxymaleimidyl, N-oxyphthalimidyl, nitrophenoxyl, N-oxyimidazolyl, and tresyl; I is a multifunctional linking moiety derived from a multinucleophilic compound; and n is an integer from 2 to 10; with the proviso that when X is a difunctional polyoxyethylene chain portion â€”Xâ€”Iâ€”Xâ€” is PEG, which is a diradical fragment represented by the formula: â€”Oâ€”(CH2â€”CH2â€”Oâ€”)aâ€”â€ƒwherein a is an integer from 20 to 300.