Patent ID: 6825353
Filing Date: 2004-11-30
Classification: A01N,A61K,C07D

Abstract:
A method for producing a compound represented by formula (2): (wherein R1, R2, R3, R4, R, X1 and Y are as defined in the following), which comprises allowing a compound represented by formula (1): [wherein R1 represents an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, a halogenoalkyl group having from 1 to 6 carbon atoms, a cyclic alkyl group having from 3 to 6 carbon atoms which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an alkoxy group having from 1 to 6 carbon atoms or an alkylamino group having from 1 to 6 carbon atoms, R2 represents a hydrogen atom or an alkylthio group having from 1 to 6 carbon atoms, wherein R2 and R1 may be combined to form a cyclic structure together with the carbon atom and nitrogen atom, to which they are bonded, and this ring may contain a sulfur atom as a constituting atom and may further have an alkyl group having from 1 to 6 carbon atoms as a substituent, R3 represents a hydrogen atom, an amino group, a thiol group, a halogenomethyl group, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, an alkynyl group having from 2 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms,wherein the amino group may have one or more substituents selected from the group consisting of a formyl group, an alkyl group having from 1 to 6 carbon atoms and an acyl group having from 2 to 5 carbon atoms, R4 represents a hydrogen atom, an amino group, a halogen atom, a cyano group, a halogenomethyl group, a halogenomethoxy group, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, an alkynyl group having from 2 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms,wherein the amino group may have one or more substituents selected from the group consisting of a formyl group, an alkyl group having from 1 to 6 carbon atoms and an acyl group having from 2 to 5 carbon atoms, and R4 and R1 may be combined to form a cyclic structure together with the carbon atom and nitrogen atom, to which they are bonded, and this ring may contain an oxygen atom, a nitrogen atom or a sulfur atom as a constituting atom and may further have an alkyl group having from 1 to 6 carbon atoms as a substituent, X1 represents a hydrogen atom or a halogen atom, X2 represents a halogen atom, and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidynyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having from 1 to 6 carbon atoms, an alkoxymethyl group having from 2 to 7 carbon atoms, a phenylalkyl group composed of an alkylene group having from 1 to 6 carbon atoms and phenyl group, or a group of the following formula: â€”B(R5)2 (wherein R5 represents a fluorine atom or an acyloxy group having from 2 to 7 carbon atoms)] to react with a nitrogen-containing basic compound represented by the following formula:Râ€”H (wherein R represents a nitrogen-containing basic substituent in which a nitrogen atom is the binding position), under a pressurized condition in a range of 1.5Ã—107 to 3.5Ã—108 Pa in the presence, if necessary, of a base.