Patent ID: 8697632
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K

Abstract:
1. An insulin prodrug analog comprising an A chain comprising SEQ ID NO: 1, or a modified derivative of SEQ ID NO: 1 comprising modification of the amino acid at position A19 to a 4-amino phenylalanine and optionally one or more amino acid substitutions at positions selected from A5, A8, A9, A10, A14, A15, A17, A18, A19 and A21; a B chain comprising SEQ ID NO: 2, or a modified derivative of SEQ ID NO: 2 comprising modification of the amino acid at position B16 or B25 to a 4-amino phenylalanine and optionally one or more amino acid substitutions at positions selected from B1, B2, B3, B4, B5, B9, B10, B13, B14, B17, B20, B22, B23, B26, B27, B28, B29 and B30 or deletions of any or all of positions B1-4 and B26-30; and a dipeptide element linked via an amide bond to the N-terminal amino group of the A chain or B chain, or the side chain amino group of an aromatic amine of a 4-amino-phenylalanine residue present at position A19, wherein said dipeptide element comprises an N-terminal C-alkylated amino acid followed by an N-alkylated amino acid, wherein the N-alkylated group of said N-alkylated amino acid is a C