Patent ID: 6331561
Filing Date: 2001-12-18
Classification: A61K,A61P

Abstract:
A method of inhibiting the expression of GFAP in a mammal, comprisingadministering an effective amount of a substituted aminomethyl-chroman of the following formula (I) ##STR7##wherein,R.sup.1 represents hydrogen,R.sup.2 represents hydrogen, hydroxyl or a radical of the formula --OCH.sub.3, --OCH.sub.2 CH.sub.3, --OCH(CH.sub.3).sub.2 or --OCH.sub.2 C(CH.sub.3).sub.2 --Cl, orR.sup.1 and R.sup.2 together form a radical of the formula ##STR8##R.sup.3 represents cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl oro-benzenesulphimidyl andn is selected from 1, 2, 3, 4 or 5,and their optical isomers and pharmaceutically acceptable salts.