Patent ID: 6200992
Filing Date: 2001-03-13
Classification: A61K,A61P

Abstract:
A pharmaceutical composition in the form of a unit dosage composition for treating cancer susceptible to treatment in animals or humans comprising:(1) a pharmaceutically acceptable carrier;(2) a safe and enhanced amount of a 1H-1,2,4-triazole of the formula: ##STR3##wherein Z is an alkylene selected from the group consisting of CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)-- and --CH.sub.2 --CH(alkyl) wherein said alkyl has from 1 to about 10 carbon atoms; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl, naphthyl and fluorenyl;(2) a safe and effective amount of chemotherapeutic agent; and(4) a safe and effective amount of potentiator wherein the amount of said potentiator enhances the effect of 1H-1,2,4-triazole in the treatment of cancer.