Patent ID: 6646128
Filing Date: 2003-11-11
Classification: A61P,C07D

Abstract:
A process for preparing a compound of the formula 1which comprises combining (a) a compound of formula 2(b) a compound of formula 3(c) one or more acids; (d) one or more water-miscible organic solvents; and (e) water; whereinR1 is phenyl optionally substituted by 1-3 substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)alkoxy, â€”OCF3, (C1-C6)alkyl-Sâ€”, (C1-C6)alkyl-S(&boxH;O)â€”, (C1-C6)alkyl-SO2â€”, amino, (C1-C6)alkylamino, di[(C1-C6)alkyl]amino, H2Nâ€”(C&boxH;O)â€”, (C1-C6)alkyl-NHâ€”(C&boxH;O)â€” and formyl; R2 is hydrogen, halo or (C1-C6)alkyl; R3 is (C1-C6)alkyl optionally substituted with one to three halo atoms; and R4 is (C1-C6)alkyl.