Patent ID: 6174884
Filing Date: 2001-01-16
Classification: A61P,C07D

Abstract:
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives of the general formula (I) ##STR124##in whichA and D together represent a radical of the formula ##STR125##whereR.sup.2 represents aryl which has 6 to 10 carbon atoms and which is optionally up to trisubstituted by identical or different substituents from the series consisting of nitro, cyano, hydroxyl, trifluoromethyl, halogen, carboxyl, or by straight-chain or branched acyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms orhydrogen, trifluoromethyl, cyano, carboxyl, or straight-chain or branched alkoxy or alkoxycarbonyl, each of which has up to 8 carbon atoms, or straight-chain or branched alkyl which has up to 8 carbon atoms and which is optionally substituted by hydroxyl,R.sup.1 represents straight-chain or branched acyl having up to 4 carbon atoms, orrepresents straight-chain or branched alkyl having up to 10 carbon atoms, optionally substituted by hydroxyl, azido or by a group of the formula --NR.sup.3 R.sup.4 or --OSO.sub.2 R.sup.5whereR.sup.3 and R.sup.4 are identical or different and represent hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, orR.sup.3 and R.sup.4 together with the nitrogen atom form a 5 or 6-membered saturated heterocycle which can optionally contain a further hetero atom selected from the series consisting of S or O or a radical --NR.sup.6whereR.sup.6 represent hydrogen or straight-chain or branched alkyl is up to 4 carbon atomsandR.sup.5 represents phenyl or straight-chain or branched alkyl having up to 5 carbon atoms,E represents a straight-chain or branched alkylene or alkenylene chain, each of which has up to 6 carbon atoms which are optionally substituted by hydroxyl, or represents the C.dbd.O group,L and V are identical or different and represent aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused, heterocycle which has up to 3 hetero atoms from the series consisting of S, N and/or O which are optionally up to trisubstituted by identical or different substituents from the series consisting of halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, straight-chain or branched alkyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms, or by a group of the formula --(W).sub.a --NR.sup.7 R.sup.8wherea is a number 0 or 1,W is a radical of the formula --CO or --SO.sub.2,R.sup.7 and R.sup.8 are identical or different and have the abovementioned meaning of R.sup.3 and R.sup.4,and/or the cycles are optionally substituted by aryl having 6 to 10 carbon atoms or by a 5- to 7-membered aromatic, optionally benzo-fused, heterocycle having up to 3 hetero atoms from the series consisting of S, N and/or O, which, in turn, are optionally up to disubstituted by identical or different substituents from the series consisting of halogen, hydroxyl, nitro, carboxyl, trifluoromethyl or by straight-chain or branched alkyl, alkox or alkoxycarbonyl, each of which has up to 5 carbon atoms, or by a group of the formula --(W').sub.b --NR.sup.9 R.sup.10whereb has the abovementioned meaning of a and is identical to this meaning or different from it,R.sup.9 and R.sup.10 have the abovementioned meaning of R.sup.3 and R.sup.4 and are identical to this meaning or different from it,W' has the abovementioned meaning of W and is identical to this meaning or different from it,L represents a radical of the formula ##STR126##orT represents a radical of the formula --CH.sub.2 --X--Y--whereX represents a bond or an oxygen or sulphur atom or the --NH-group,Y represents a straight-chain or branched alkylene chain having up to 9 carbon atoms,and the tautomers and salts of these.