Patent ID: 7964639
Filing Date: 2011-06-21
Classification: A61K,A61P,A61Q,C07J

Abstract:
1. A method of treating a disease caused by abnormal cell proliferation or cell differentiation where the disease is psoriasis, or the disease is a skin disorder selected from the group consisting of dermatitis, eczema and keratosis, comprising administering to a patient with said disease an effective amount of a retinoid ester said retinoid ester having the formula where R is a retinoyl of a retinoid selected from the group consisting of all-trans-retinoic acid, 9-cis-retinoic acid, 11-cis-retinoic acid, 13-cis-retinoic acid, 9,13-di-cis-retinoic acid, TTNPB, TTNN, TTAB, UAB8, AM8O, AM580, AM555S, AGN 193836, AGN 190299, CD 2019, CD 417, R 0 48-2249, R 0 44-4753, R 0 10-9359, SR 11254, BMS 185354, AGN 190299, CD 437 (AHPN), SR 11247, SR 11217, SR 11237, AGN 191701, LDG 100268, LDG 100568, LGD 100754, R 0 25-7386, BMS 188970, SR 11004, and SR 11203 and R 1 is a highly sterically hindered functional group having the formula where R 3 , R 4 and R 5 which may be the same or different are each independently selected from the group consisting of a straight chain or branched alkyl group in all isomeric forms having 1 to 5 carbon atoms.