Patent ID: 7625550
Filing Date: 2009-12-01
Classification: A01K,A61K

Abstract:
1. A method to monitor progression, angiogenesis and/or metastasis of tumor cells or tissue on the internal organs in an animal having a tumor, which method comprises observing within the animal through an intact body wall or skull fluorescent tumor cells and/or tissue on the internal organs which are present at a suitable depth for observing in said animal through an opening of a skin flap and through a portion of the intact body wall or skull of the animal under the skin flap which remains when the skin and subcutaneous connective tissue of the skin flap is separated therefrom; wherein said animal is an immunocompromised or a syngeneic experimental animal, and wherein said skin flap is arranged to be reversibly opened and closed to permit observation of fluorescent tumor cells and/or tissue over time, whereby the progression, angiogenesis and/or metastasis of said tumor cells or tissue on the internal organs is monitored.