Patent ID: 7332527
Filing Date: 2008-02-19
Classification: A61K,A61P,Y10T

Abstract:
1. A method for synthesizing an amphiphilic block copolymer micelle comprising: forming block copolymers each having an ionically-charged polymeric segment and a nonioinically charged polymeric segment, wherein the ionically charged polymeric segment is a polyanionic form of polymethacrylic acid or polyacryilic acid and wherein the nonionically charged segment is poly(ethylene oxide) neutralizing the ionically-charged polymeric segment with moieties of opposite charge under conditions that allow for self assembly of polymer micelles, wherein the moieties of opposite charge are divalent or trivalent metals covalently cross-linking the neutralized ionically-charged polymer segments with a cross-linking agent removing the moieties of opposite charge and unreacted cross-linking agent replacing the moieties of opposite charge that were neutralizing the ionically charged polymeric segments with another charged agent after the removing step.