Patent ID: 6271358
Filing Date: 2001-08-07
Classification: C07H

Abstract:
An oligonucleotide having at least one nucleoside of the formula: ##STR4##whereinQ is a heterocyclic base;L.sub.1, L.sub.2 and L.sub.3 form a ring system having from about 4 to about 7 carbon atoms or having from about 3 to about 6 carbon atoms and 1 or 2 hetero atoms wherein said hetero atoms are oxygen, nitrogen or sulfur and wherein said ring system is aliphatic, unsaturated aliphatic, aromatic or heterocyclic;R is OX, SX, N(H)X or NX.sub.2 ;X is H, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 haloalkyl, C(.dbd.NH)N(H)Z, C(.dbd.O)N(H)Z and OC(.dbd.O)N(H)Z;Y is alkyl or haloalkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, alkynyl having 2 to about 10 carbon atoms, aryl having 6 to about 14 carbon atoms, N(H)X, NX.sub.2, OX, halo, SX or CN;n is 0, 1 or 2; andZ is H or C.sub.1 -C.sub.8 alkyl.