Patent ID: 6262059
Filing Date: 2001-07-17
Classification: A61K

Abstract:
A method of treating a patient having precancerous lesions sensitive to compounds below and in the need of treatment, comprising administering to the patient a pharmacologically effective amount of a compound of the formula: ##STR123##wherein R1, R2, R3 and R4, each of which may be the same or different, are selected from a hydrogen atom, a halogen atom, an alkoxy group having from 1 to 6 carbon atoms, or a cyano groupR5 and R6 form a piperidino group which may be substituted;R7 is selected from a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;R8 is a benzyl group which may be substituted, said substitutions, which may be the same or different, are selected from a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkoxyalkyl group having from 2 to 8 carbon atoms, an alkenyl group having from 2 to 8 carbon atoms, an acyl group, an acylamino group, an alkylsulfonylamino group, a hydroiminoalkyl group, an alkyloxycarbonylamino group, an alkyloxybarbonyloxy group or a heteroaryl group which may be substituted; or two of said substitutions may together form a methylenedioxy group; andY is a group represented by the formula --(CH2)q-- (wherein q is 0 or an integer of 1 to 8), when q is an integer of 1 to 8, each carbon atom may have from 1 to 2 substituents.