Patent ID: 6403602
Filing Date: 2002-06-11
Classification: A61K,A61P,C07D

Abstract:
A method of treating pain comprising administering to a person in need thereof a therapeutically effective amount of a compound selected from the group consisting of the following formulas I and II: wherein X is selected from the group consisting of â€”OR2, â€ƒand wherein R1 may be a straight or branched chain alkyl group having 1-5 carbon atoms or alkenyl group having 2-5 carbon atoms, wherein R2 is an alkyl having 1-3 carbon atoms, wherein R3 is H, n-alkyl, or branched alkyl with 2-10 carbon atoms, cycloalkyl with 3-10 carbon atoms, aralkyl with 5-10 carbon atoms, phenyl, n-alkenyl or branched alkenyl with 2-10 carbon atoms, and n-alkynyl or branched alkynyl with 2-10 carbon atoms, and wherein R4 is H or n-alkyl or branched alkyl with 1-10 carbon atoms, cycloalkyl with 3-10 carbon atoms, aralkyl with 5-10 carbon atoms, n-alkenyl or branched alkenyl with 2-10 carbon atoms, and n-alkynyl or branched alkynyl with 2-10 carbon atoms, with the proviso that when R3 is a methyl group, R1 is neither a methyl group nor â€”CH2â€”CH&boxH;C(CH3)2 group; and wherein X is selected from the group consisting of â€”OR2, â€ƒand wherein R1 may be straight or branched chain alkyl group having 1-5 carbon atoms or alkenyl group having 2-5 carbon atoms, wherein R2 is an alkyl having 1-3 carbon atoms, wherein R3â€² is H, n-alkyl, or branched alkyl with 2-10 carbon atoms, cycloalkyl with 3-10 carbon atoms, aralkyl with 5-10 carbon atoms, n-alkenyl or branched alkenyl with 2-10 carbon atoms, and n-alkynyl or branched alkynyl with 2-10 carbon atoms, and wherein R4 is H or n-alkyl or branched alkyl with 1-10 carbon atoms, cycloalkyl with 3-10 carbon atoms, aralkyl with 5-10 carbon atoms, n-alkenyl or branched alkenyl with 2-10 carbon atoms, and n-alkynyl or branched alkynyl with 2-10 carbon atoms, with the proviso that when R3 is a methyl group, R1 is not a methyl group.