Patent ID: 6284752
Filing Date: 2001-09-04
Classification: A61K

Abstract:
A method for preparing a pharmaceutical composition comprising formulating a neutral, anionic or cationic metal complex having at least one site for coordination with NO, of formula:[M.sub.a (X.sub.b L).sub.c Y.sub.d Z.sub.e ].sup.n.+-. (formula I),with a pharmaceutically acceptable carrier, wherein the complex is present in an amount sufficient for attenuation of NO levels where NO is implicated in disease, andwherein:M is a metal ion or a mixture of metal ions;X is a cation or a mixture of cations;L is a ligand, or mixture of ligands each containing at least two different donor atoms selected from the elements of Group IV, Group V or Group VI of the Periodic Table;Y is a ligand, or a mixture of the same or different ligands each containing at least one donor atom or more than one donor atom, which donor atom is selected from the elements of Group IV, Group V or Group VI of the Periodic Table;andZ is a halide or pseudohalide ion or a mixture of halide ions and pseudohalide ions;a=1-3; b=0-12; c=0-18; d=0-18; e=0-18; and n=0-10;provided that at least one of c, d and e is 1 or more;and where c is 0; b is also 0;and where a is 1; c, d and e are not greater than 9;and where a is 2; c, d and e are not greater than 12.