Patent ID: 6303602
Filing Date: 2001-10-16
Classification: A61P,C07D,Y02P

Abstract:
A compound of the following formula: ##STR34##and the salts thereof, whereinA is hydrogen, halo, hydroxy, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo C.sub.1 -C.sub.6 alkoxy, oxo, OY wherein Y is a hydroxy protecting group, or absent;the broken line represents an optional double bond with proviso that if the broken line ia a double bond, then A is absent;Ar.sup.1 is phenyl optionally substituted by one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy, CF.sub.3, carboxy-C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alkoxy-carbonyl-C.sub.1 -C.sub.4 alkoxy;Ar.sup.2 is aryl or heteroaryl selected from phenyl, naphthyl, thienyl, furyl, and pyrrolyl, the aryl or heteroaryl being optionally substituted by one or more substituents selected from halo, hydroxy, amino, nitro, carboxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylamino, di C.sub.1 -C.sub.4 alkylamino, halo C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkythio and sulfonyl methyl;R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or OY wherein Y is a hydroxy protecting group; andR.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a piperidine or morpholine ring, optionally subsituted by C.sub.1 -C.sub.3 alkyl or halo.