Patent ID: 6710051
Filing Date: 2004-03-23
Classification: A61K,A61P,G01N

Abstract:
A method of treating an eye disorder characterized by an abnormal past rate of longitudinal growth of the eye by altering the subsequent rate of longitudinal growth of the eye so as to at least partially counteract said abnormal past rate, comprising administering to an individual in need thereof a therapeutically effective amount of one or more substances selected from the group of compounds of the general formula I, II and III wherein R1, R3, R7, and R9 are independently selected from the group consisting of hydrogen, optionally substituted C1-20-alkyl, optionally substituted C2-20-alkenyl, optionally substituted C4-20-alkadienyl, optionally substituted C6-20-alkatrienyl, optionally substituted C2-20-alkynyl, optionally substituted C1-20-alkoxycarbonyl, optionally substituted C1-20-alkylcarbonyl, formyl, optionally substituted aryl, optionally substituted aryloxycarbonyl, optionally substituted arylcarbonyl, optionally substituted heteroaryl, optionally substituted heteroaryloxycarbonyl, optionally substituted heteroarylcarbonyl, carbamoyl, mono- and di(C1-20-alkyl)aminocarbonyl, mono- and di(C1-20-alkyl)amino-C1-20-alkyl-aminocarbonyl, and halogen, andR8 is selected from the group consisting of hydrogen, optionally substituted C1-20-alkyl, optionally substituted C2-20-alkenyl, optionally substituted C4-20-alkadienyl, optionally substituted C6-20-alkatrienyl, optionally substituted C2-20-alkynyl, optionally substituted C1-20-alkoxy, optionally substituted C2-20-alkenyloxy, carboxy, hydroxy, optionally substituted C1-20-alkoxycarbonyl, optionally substituted C1-20-alkylcarbonyl, formyl, optionally substituted aryl, optionally substituted aryloxycarbonyl, optionally substituted aryloxy, optionally substituted arylcarbonyl, optionally substituted arylcarbonyl, optionally substituted heteroaryl, optionally substituted heteroaryloxycarbonyl, optionally substituted heteroaryloxy, optionally substituted heteroarylcarbonyl, amino, mono- and di(C1-20-alkyl)amino, carbamoyl, mono- and di(C1-20-alkyl) aminocarbonyl, amino-C1-20-alkyl-aminocarbonyl, mono- and di(C1-20-alkyl) amino-C1-20-alkyl-aminocarbonyl, optionally substituted C1-20-alkylcarbonylamino, guanidino, carbamido, optionally substituted C1-20-alkanoyloxy, sulphono, optionally substituted C1-20-alkylsulphonyloxy, nitro, sulphanyl, optionally substituted C1-20-alkylthio, and halogen, in which at least one of the substances is administered systemically.