Patent ID: 9029135
Filing Date: 2015-05-12
Classification: A61K,A61P,C12N

Abstract:
1. An isolated nucleic acid comprising: an antisense sequence consisting of a sequence complementary to a fragment of a sequence coding for a kanamycin resistance protein; and a sequence which encodes an immunogenic polypeptide; wherein the fragment is at least 100 nucleotides and at most 500 nucleotides in length; wherein the antisense sequence encodes at least one immunogenic polypeptide selected from the group consisting of a polypeptide of sequence SEQ ID NO: 18 and a polypeptide of sequence SEQ ID NO: 19; wherein the sequence coding for the kanamycin resistance protein has a sequence consisting of nucleotides 1226 to 2020 of SEQ ID NO: 9; and wherein said antisense sequence is under control of a mammalian promoter allowing its transcription.