Patent ID: 8304422
Filing Date: 2012-11-06
Classification: A61P,C07D

Abstract:
1. A method of inhibiting an activity of a JAK kinase, comprising contacting a cell comprising the JAK kinase with an amount of a compound effective to inhibit an activity of the JAK kinase wherein the compound is according to formula I: or pharmaceutically acceptable salt thereof, wherein: ring A is aryl or heteroaryl; ring B is aryl, heteroaryl, cycloalkyl, or heterocyclic; p is 0, 1, 2 or 3 when ring A is monocyclic or p is 0, 1, 2, 3, 4, or 5 when ring A contains multiple rings; q is 0, 1, 2 or 3 when ring B is monocyclic or q is 0, 1, 2, 3, 4, or 5 when ring B contains multiple rings; X is selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halo, nitro, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl; W is —SO -alk- is selected from the group consisting of straight or branched chain C R each R R R each R R R R provided: a) when W is —SO b) when W is —N(R c) when W is —SO d) when W is —SO