Patent ID: 6894167
Filing Date: 2005-05-17
Classification: A61P,C07D

Abstract:
1. A method of preparation of (S)-N-tert-butyl-1,2,3,4 tetrahydmisoquinoiine-3-carboxamide comprising the following steps: a) (3S)-1,2,3,4-tetrahydroisoqulnoline-3-carboxyiic acid is reacted with formic acid to give the compound of formula:  b) the compound thus obtained is reacted with tert-butylamine to give the compound of formula:  the compound thus obtained is then treated with at least one second acid to give (S)-N-tert-butyl-1 ,2,3.4-tetrahydroisoquinoline-3-carboxamide.