Patent ID: 6022694
Filing Date: 2000-02-08
Classification: A61P,G01N

Abstract:
A method of screening for a compound that competes with a collagen for binding to the extracellular domain of a Tyro-10 (DDR-2) receptor comprising:a) contacting a known amount of the extracellular domain of Tyro-10 (DDR-2) receptor to the collagen under conditions in which the collagen is capable of binding to the extracellular domain;b) determining the amount of the extracellular domain that binds to the collagen;c) contacting a known amount of the extracellular domain of a Tyro-10 (DDR-2) receptor to collagen, in the presence of a test compound, under conditions in which the collagen is capable of binding to the extracellular domain;d) determining the amount of the extracellular domain that binds to the collagen in the presence of the test compound;e) comparing the amount of extracellular domain that binds to the collagen from (b) with the amount of extracellular domain that binds to the collagen from (d), wherein a lesser amount in (d) indicates that the test compound competes with collagen for binding to the extracellular domain of a Tyro-10 (DDR-2) receptor.