Patent ID: 7829726
Filing Date: 2010-11-09
Classification: A01N,C07D

Abstract:
1. A method for manufacturing sertaconazole mononitrate (I) which comprises: (i) the reaction of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol (II) with 3-bromomethyl-7-chlorobenzo [b] thiophene (III) in the presence of tetrabutylammonium hydrogen sulfate (IV, Z═HSO (ii) dissolving sertaconazole mononitrate monohydrate in a mixture of ethanol and water, heating the mass at 75-80° C., adding the mixture over an aqueous solution of nitric acid cooled at 5-15° C., filtering, drying at 60-70° C., sieving and finally drying at 80-90° C.