Patent ID: 6033644
Filing Date: 2000-03-07
Classification: A61K

Abstract:
A method of imaging tissue in a host, by a particular imaging modality, comprising administering to the host an amount of a biomodulator bonded to a moiety per se detectable by the modality effective for imaging of said tissue, wherein the biomodulator is:(a) a compound of formula (I) ##STR6## wherein R.sup.1 is an optically substituted aromatic, cycloaliphatic or heterocyclic ring system,R.sup.2 is --CH.sub.2 OH, --CHO, --COOR.sup.3, --COSR.sup.3, --CONR.sup.8 R.sup.9 or the corresponding lactone ##STR7## wherein R.sup.3 is H or C.sub.1-10 -alkyl,R.sup.4 and R.sup.5 are each independently H or C.sub.1-6 -alkyl,R.sup.6 and R.sup.7 are each independently OR, NHR or SH wherein R is H or C.sub.1-4 -alkanoyl,R.sup.8 and R.sup.9 are each independently H or C.sub.1-10 -alkyl, andX is C.sub.2-3 -alkylene, C.sub.2-3 -alkenylene, C.sub.2-3 -alkynylene, a cyclopropylene group, --OCH.sub.2 -- or --SCH.sub.2 --;(b) a compound of formula (II) (swainsonine) ##STR8## or an indolizidine alkaloid having an electronically similar 1,3-diol structure;(c) cellular activator and differentiator (CAD); or(d) pokeweed mitogen,and scanning the host with the image modality to obtain an image of the tissue.