Patent ID: 8273375
Filing Date: 2012-09-25
Classification: A61K

Abstract:
1. A composition suitable for oral administration comprising a casing that disintegrates in a gastric pH range and that contains pellets, particles, granules or agglomerates that have a mean diameter ranging between 50 and 2,500 μm and comprising: a) an inner matrix layer comprising b) a film-applied outer coating, consisting essentially of an anionic polymer or copolymer, and, optionally, one or more pharmaceutically customary excipients, wherein the active substance in the inner matrix layer has a water-solubility as defined in the German Pharmacopeia DAB 10 of at least 30 parts by volume of water for 1 part by weight of the active substance, wherein the lipophilic matrix with its active substance is embedded in a matrix made from the mucoadhesive polymer used jointly with an acid or a buffer system which is present in the matrix or in or on a core to which the matrix is applied, which matrix comprises a chitosan and is adjusted to pH 5.0-5.5 by means of the acid or a buffer system, and is combined with a film-applied outer coating which begins to dissolve in the range of pH 6.0 to 8.0.