Patent ID: 7148347
Filing Date: 2006-12-12
Classification: A61P,B01J,C07D,C07K

Abstract:
1. A process for preparing a compound of formula (I): wherein W is CH or N, R wherein each R R said cycloalkyl, aryl or Het being substituted with R wherein R or R R D is a 3 to 7-atom saturated alkylene chain; R C A is an amide of formula —C(O)—NH—R or A is a carboxylic acid or a pharmaceutically acceptable salt or ester thereof; said process comprising reacting a macrocyclic compound of formula (IX) with a compound of formula (X) in a polar non-protic organic solvent in the presence of an organic or inorganic base: wherein W, R 1 , R 2 , R 3 , R 4 , D and A are as defined for formula (I), and R 12 is selected from p-tolyl, p-bromophenyl, p-nitrophenyl, methyl, trifluoromethyl, perfluorobutyl and 2,2,2-trifluoroethyl; and when A is a carboxylic acid ester group in the resulting compound of formula (I), optionally subjecting the compound of formula (I) to hydrolysis conditions to obtain a compound of formula (I) wherein A is a carboxylic acid group; and when A is a carboxylic acid group in the resulting compound of formula (I), optionally coupling this compound with a sulfonamide of formula R