Patent ID: 8785422
Filing Date: 2014-07-22
Classification: C07C

Abstract:
1. A compound having the formula: where X is selected from the group consisting of hydrogen and a hydroxy-protecting group, and where R may be an alkyl, hydrogen, hydroxyalkyl or fluoroalkyl group, or R may represent a side chain of the formula: where the stereochemical center at carbon 20 may have the R or S configuration, and where Z in the above side chain structure is selected from Y, —OY, —CH 2 OY, —C≡CY and —CH═CHY, where the double bond in the side chain may have the cis or trans geometry, and where Y is selected from hydrogen, methyl, —COR 5 and a radical of the structure: where m and n, independently, represent the integers from 0 to 5, where R 1 is selected from hydrogen, deuterium, hydroxy, protected hydroxy, fluoro, trifluoromethyl, and C 1-5 -alkyl, which may be straight chain or branched and, optionally, bear a hydroxy or protected-hydroxy substituent, and where each of R 2 , R 3 , and R 4 , independently, is selected from deuterium, deuteroalkyl, hydrogen, fluoro, trifluoromethyl and C 1-5 alkyl, which may be straight-chain or branched, and optionally, bear a hydroxy or protected-hydroxy substituent, and where R 1 and R 2 , taken together, represent an oxo group, or an alkylidene group having a general formula C k H 2k — where k is an integer, the group ═CR 2 R 3 , or the group —(CH 2 ) p —, where p is an integer from 2 to 5, and where R 3 and R 4 , taken together, represent an oxo group, or the group —(CH 2 ) q —, where q is an integer from 2 to 5, and where R 5 represents hydrogen, hydroxy, protected hydroxy, or C 1-5 alkyl and wherein any of the CH-groups at positions 20, 22, or 23 in the side chain may be replaced by a nitrogen atom, or where any of the groups —CH(CH 3 )—, —(CH 2 ) m —, —CR 1 R 2 — or —(CH 2 ) n — at positions 20, 22, and 23, respectively, may be replaced by an oxygen or sulfur atom.