Patent ID: 6399599
Filing Date: 2002-06-04
Classification: A61K,C07D,C07K

Abstract:
A compound of formula I whereinn is 2; R1 is H, C1-4alkyl, aryl, or aryl-C1-4alkyl; Y is C1-4alkylene, â€”COâ€”C1-4alkylene, â€”COâ€”C2-5alkenylene, â€”COâ€”NHâ€”, â€”COâ€”C1-3alkylene-NHâ€”, or â€”COâ€”Oâ€”; R2 is phenyl, naphthyl, dihydro- or tetrahydro-naphthyl, biphenylyl, pyridyl, quinolyl, isoquinolyl, dihydro- or tetrahydro-quinolyl or -isoquinolyl, benzo-thienyl, indolyl or pyridyl-phenyl, each being optionally substituted by CF3, halogen, OH, C1-4alkoxy, amino, mono- or di-C1-4alkyl substituted amino, phenyl, benzyl or C1-4alkyl optionally substituted by amino; R3 is propyl, isopropyl, butyl, isobutyl, 1-methylpropyl, phenyl, benzyl or aminobutyl; R4 is biphenylyl, benzyl, hydroxy-benzyl, &agr;- or &bgr;-naphthyl-methyl, 5,6,7,8-tetrahydro-&bgr;-naphthyl-methyl or indolyl-methyl, each being optionally substituted on the ring by CF3, halogen, OH, C1-4alkoxy, amino, mono- or di-C1-4alkyl substituted amino, phenyl, benzyl or C1-4alkyl optionally substituted by amino; and X is â€”CN, â€”NR5R6, or â€”Oâ€”R8 Wherein R5 is H, C1-6alkyl, aryl or aryl-C1-4alkyl; R6 is H or C1-6alkyl; and R8 is H, C1-4alkyl, aryl or aryl-C1-4alkyl; or a pharmaceutically acceptable salt thereof.