Patent ID: 6495607
Filing Date: 2002-12-17
Classification: A61P,C07C,C07D

Abstract:
A benzocycloheptene of formula I in whichR1 and R2, independently of one another, is H, a hydroxy group, an optionally substituted C1-C10 alkoxy group, an optionally substituted C1-C10 alkanoyloxy group or an optionally substituted C7-C15 aroyloxy group; Y is a side chain â€”Aâ€”Bâ€”Z; A is a direct bond or an oxygen atom; B is a straight-chain or branched-chain, optionally substituted alkylene, alkenylene or alkinylene group with up to 10 carbon atoms; Z is a group â€”Dâ€”SOxâ€”Eâ€”G, an amino group â€”NR7R8 or a substituent G; D is a direct bond or a group â€”NR3(R4â€”); R3 is a straight-chain or branched-chain alkyl, alkenyl or alkinyl group with up to 10 carbon atoms; R4 is a straight-chain or branched-chain, optionally substituted alkylene, alkenylene or alkinylene group with up to 10 carbon atoms; x is 0, 1 or 2; E is a straight-chain or branched-chain, optionally substituted alkylene, alkenylene or alkinylene group with up to 10 carbon atoms; G is a partially or completely fluorinated straight-chain or branched-chain alkyl group with up to 5 carbon atoms, an optionally substituted aryl radical, a carbamoyl radical â€”C(O)â€”NR5R6, a halogen atom or a hydrogen atom; R5, R6, R7 R8, independently of one another, are each H, a straight chain or branched-chain, optionally partially fluorinated alkyl, alkenyl or alkinyl radical with up to 14 carbon atoms, which is optionally interrupted by one to three heteroatoms â€”Oâ€” and â€”Sâ€” or groupings â€”NR9â€”, an aryl radical that is optionally substituted in one or two places, a C3-C10 cycloalkyl radical that is optionally substituted in one or two places, a C4-C15 cycloalkylalkyl radical that is optionally substituted in one or two places, a C7-C20 aralkyl radical that is optionally substituted in one or two places, an optionally substituted aminoalkyl radical, a biphenylene radical or a radical of formula â€”C(O)R10;R9 is H or C1-3 alkyl; and R10 is H, a straight chain or branched-chain, optionally partially fluorinated alkyl, alkenyl or alkinyl radical with up to 14 carbon atoms, which is optionally interrupted by one to three heteroatoms â€”Oâ€” and â€”Sâ€” or groupings â€”NR9, an aryl radical that is optionally substituted in one or two places, a C3-C10 cycloalkyl radical that is optionally substituted in one or two places, a C4-C15 cycloalkylalkyl radical that is optionally substituted in one or two places, a C7-C20 aralkyl radical that is optionally substituted in one or two places, an optionally substituted aminoalkyl radical, or a biphenylene radical; or a physiologically compatible salt thereof; wherein in â€”Aâ€”Bâ€”Z, if A is an oxygen atom and Z is G, G cannot be a hydrogen atom or a halogen atom, or if A is an oxygen atom and Z is an amino group â€”NR7R8, in which R7 and R8 in each case a methyl group, B has at least 3 carbon atoms, or if B is â€”CH2H4â€” and Z is â€”NR7R, then R7 and R8 are not the same.