Patent ID: 6630476
Filing Date: 2003-10-07
Classification: C07D

Abstract:
A compound of Formula (I), wherein: D is Ar1 or heteroaryl , each optionally substituted with 1 to 5 R5 groups and each is attached to an unsaturated carbon atom; R1 is H, Ar2, heteroaryl, heterocyclyl, or carbocyclyl; or C1-C6 alkyl, C2-C4 alkenyl, or C2-C4 alkynyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, Ar2, heteroaryl, heterocyclyl, carbocyclyl, OR12, F, Cl, Br, I, CF3, and NO2; R2 is H, or C1-C10 alkyl, C3-C10 alkenyl, or C3-C10 alkynyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, Ar2, heteroaryl, heterocyclyl, carbocyclyl, F, Br, Cl, I, CN, OR12, SR15, NO2, NR9COR13, NR9CONR11R10, NR9CO2R12, NR11R10, and CONR11R10; R3 is H, Ar2, heteroaryl, heterocyclyl, or carbocyclyl; or C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or C1-C4 haloalkyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, Ar2, heteroaryl, heterocyclyl, carbocyclyl, NO2, F, Cl, Br, I, NR9COR7, NR9CO2R7, OR7, CONR10R11, and CO(NOR12)R7; R4 is NR11R10; R5 is independently selected at each occurrence from: NO2, F, Cl, Br, I, CN, NR10R11, NR9COR13, NR9CO2R7, COR13, R13, OR12, CONR10R11, CO(NOR9)R10, CO2R12, and S(O)nR14or C1-C6 alkyl, C2-C10 alkenyl, and C2-C10 alkynyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, C3-C6 cycloalkyl, CF3, NO2, F, Cl, Br, I, CN, NR6R7, NR9COR7, NR9CO2R7, COR7, OR7, CONR6R7, CO2R7, CO(NOR9)R7, and S(O)nR7; R6 is independently selected at each occurrence from: H, â€”CH2Ar2, Ar2, heteroaryl, heterocyclyl, and carbocyclyl; or C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, and C1-C4 haloalkyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C1-C4 haloalkyl, CN, F, Cl, Br, I, OR12, NO2, S(O)nR14, COR13, CO2R12, OC(O)R14, NR9COR13, N(COR13)2, NR9CONR11R10, NR9CO2R12, NR11R10, CONR11R10, Ar2, heteroaryl, heterocyclyl, and carbocyclyl; R7 is independently selected at each occurrence from: H, â€”CH2Ar2, Ar2, heteroaryl, heterocyclyl, and carbocyclyl; or C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, and C1-C4 haloalkyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C1-C4 haloalkyl, CN, F, Cl, Br, I, OR12, NO2, S(O)nR14, COR13, CO2R12, OC(O)R13, NR9COR13, N(COR13)2, NR9CONR11R10, NR9CO2R12, NR11R10, CONR11R10, Ar2, heteroaryl, heterocyclyl, and carbocyclyl; Ar1 is phenyl or naphthyl; Ar2 is phenyl or naphthyl, each optionally substituted with 1 to 5 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, CN, F, Cl, Br, I, OR12, NO2, S(O)nR14, COR13, CO2R12, OC(O)R13, NR9COR13, N(COR13)2, NR9CONR11R10, NR9CO2R12, NR11R10, and CONR11R10; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, pyrrolyl, imidazolyl, pyranyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, indazolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzothiazolyl, isoxazolyl, pyrazolyl, 2,3-dihydrobenzothienyl or 2,3-dihydrobenzofuranyl; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 5 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, CN, F, Cl, Br, I, OR12, NO2, S(O)nR14, COR13, CO2R12, OC(O)R13, NR9COR13, N(COR13)2, NR9CONR11R10, NR9CO2R12, NR10 R11, and CONR11R10; carbocyclyl is a saturated or partially unsaturated C3-C10 membered ring, optionally substituted with 1 to 5 substituents independently selected at each occurrence from C1-C6 alkyl, CF3, CN, F, Cl, Br, I, OR12, SR10, S(O)nR14, COR13, CO2R12, OC(O)R13, NR9COR13, N(COR13)2, NR9CONR11R10, NR9CO2R12, NR10R11, and CONR11R10; R9 is independently selected at each occurrence from H, C1-C4 alkyl, and C3-C6 cycloalkyl; R10 is H, heterocyclyl, or carbocycle; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ar2, or heteroaryl, each optionally substituted with 1-3 F, Cl, Br, I, NO2, CF3, CN, or OR12; R11 is H, heterocyclyl, or carbocycle; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ar2, or heteroaryl, each optionally substituted with 1-3 C1-C6 alkyl, C3-C6 cycloalkyl, F, Cl, Br, I, NO2, CF3, CN, or OR12; alternatively, R10 and R11 can combine to form piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine, each optionally substituted with 1-3 C1-C4 alkyl groups; R12 is independently selected at each occurrence from H, C1-C6 alkyl, C3-C6 cycloalkyl, and C1-C4 haloalkyl; R13 is selected from H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy C1-C6 alkyl, C3-C6 cycloalkyl, and C1-C6 alkyl; R14 is independently selected at each occurrence from C1-C6 alkyl, C3-C6 alkyl, and phenyl, each subsituted by 1-3 C1-C4 alkyl, C1-C4 haloalkyl or OR15; and R15 is independently selected at each occurrence from H, C1-C6 alkyl, C3-C6 cycloalkyl, and C1-C4 haloalkyl.