Patent ID: 8748403
Filing Date: 2014-06-10
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method of reducing toll-like receptor 2 (TLR2) mediated inflammation associated with herpes simplex virus (HSV) infection in a subject in need thereof, the method comprising: identifying a subject with HSV who has or is at risk for developing TLR2 mediated inflammation associated with HSV; and administering to the subject a therapeutically effective amount of a TLR2 antisense nucleic acid or small interfering RNA (siRNA) for a period of time and under conditions sufficient to promote a decrease in the expression of TLR2 mRNA, wherein the antisense nucleic acid or siRNA specifically targets all or a portion of human TLR2 mRNA (SEQ ID NO:1) and promotes a decrease in the expression of TLR2 mRNA upon binding thereto, thereby reducing TLR2 mediated inflammation associated with HSV infection in the subject.