Patent ID: 6589980
Filing Date: 2003-07-08
Classification: C07D

Abstract:
A compound of formula I, having the structure whereinY1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are each, independently, hydrogen, â€”OR, halogen, â€”CF3, â€”CF2CF3, â€”CH2CF3, â€”SR2, â€”CN, â€”CH2CN, â€”CH2CH2CN, â€”CH&boxH;CHCN, â€”NO2, â€”CH2NO2, â€”CH2CH2NO2, â€”CH&boxH;CHNO2, or â€”COR3; R is hydrogen, alkyl of 1-6 carbon atoms, â€”CF3, benzyl, â€”CO2R1, or â€”COR3; R1 is â€”CF3, alkyl of 1-6 carbon atoms, or benzyl; R2 is hydrogen or alkyl of 1-6 carbon atoms; R3 is alkyl of 1-6 carbon atoms, phenyl, thienyl, furyl, â€”NR4R5, or â€”CF3; R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or are taken together to form a 5-7 memebered saturated heterocyclic ring containing a nitrogen and 4-6 carbon atoms; or a pharmaceutically acceptable salt thereof, with the proviso that at least one of Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 is â€”OR; and at least one of Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 is not hydrogen or â€”OR.