Patent ID: 6740759
Filing Date: 2004-05-25
Classification: C07D

Abstract:
A method of producing 2-alkyl-4isothiazoline-3-one represented by the general formula (III), wherein the compound represented by formula (II), is reacted with chlorine as a chlorinating agent in dichloromethane as a solvent, in which hydrogen chloride is insoluble or exhibits low solubility, at a temperature of 39-41Â° C., according the reaction formula represented by: wherein R in the compounds of formulae (II) and (III) represents a C1 to C8 alkyl group or an aralkyl group, and wherein the amount of a 5-chloro-2-alkyl-4-isothiazoline-3-one contained in the 2-alkyl-4-isothiazoline-3-one produced is less than 0.1%.