Patent ID: 6331314
Filing Date: 2001-12-18
Classification: A61K,A61P,B01F,Y10T

Abstract:
A process for preparing a parenterally administrable pharmaceutical preparation comprising a liposome dispersion as a carrier for a pharmaceutical active compound, said process comprising preparing the liposome dispersion by a process comprising:a) feeding an aqueous predispersion comprising one or more amphiphilic substances to a high-pressure homogenizer; andb) pumping the aqueous predispersion under a pressure ranging from 600 bar to 900 bar through a high-pressure homogenizer apparatus;said high-pressure homogenizer comprising:i) at least one homogenizer nozzle consisting of a hard ceramic plate pressed into a steel body, said hard ceramic plate comprising a bore having a diameter ranging from 0.1 mm to 0.5 mm;ii) an inlet channel to the bore incorporated into said steel body; andiii) an outlet channel from the bore incorporated into said steel body.