Patent ID: 8338366
Filing Date: 2012-12-25
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A method of delivering a FUS-1 polypeptide to a cell, comprising contacting a cell with a nanoparticle-polypeptide complex comprising one or more FUS-1 polypeptides, wherein the one or more FUS-1 polypeptides: (1) comprise the sequence of KLRRVHKNLPPQGPVKLDHPR (SEQ ID NO:13); (2) comprise the sequence of VLRRVHVNLPPQGPVVLDHPR (SEQ ID NO:14); (3) comprise the sequence of ETPVTVNGQVRAPLRRVHV (SEQ ID NO:17); (4) consists of the sequence of KLRRVHKNLIPQGIVKLDHPR (SEQ ID NO:1); or (5) consists of the sequence of ETIVTKNGQKRAKLRRVHK (SEQ ID NO:16) wherein the one or more FUS-1 polypeptides are each modified by the addition of a chemical moiety to facilitate uptake into the cell.