Patent ID: 6869936
Filing Date: 2005-03-22
Classification: A61K,C12N

Abstract:
1. A method of delivering a nucleic acid of interest to fibroblast-like or macrophage-like cells associated with a synovial cavity, said method comprising: introducing a recombinant adenovirus of a subgroup C origin comprising the nucleic acid of interest and having a tissue tropism for fibroblast-like or macrophage-like cells associated with a synovial cavity into the synovial cavity; wherein the recombinant adenovirus's fiber comprises a fiber tail and a penton base of an adenovirus serotype of subgroup C origin and at least a knob domain of the fiber is of a second adenovirus serotype associated therewith, said second adenovirus serotype selected from the group consisting of serotype 11, serotvpe 16, serotype 35, and serotype 51; and allowing the recombinant adenovirus to infect the fibroblast-like or macrophage-like cells associated with the synovial cavity.