Patent ID: 7247316
Filing Date: 2007-07-24
Classification: A61K,A61P

Abstract:
1. A kit for use in the treatment of a neoplasia in a mammal, said kit comprising: (a) a first vial comprising a solution comprising vincristine sulfate at a concentration of approximately 1 mg/ml, mannitol at a concentration of approximately 100 mg/ml, wherein said solution has a pH in the range of 3.5 to 5.5; (b) a second vial comprising a citrate-buffered solution comprising liposomes comprising sphingomyelin and cholesterol in a ratio of 75/25 (mol % sphingomyelin/mol % cholesterol) to 50/50 (mol % sphingomyelin/mol % cholesterol); (c) a third vial comprising a buffer solution comprising dibasic sodium phosphate heptahydrate at a concentration of approximately 14.2 mg/ml; and (d) instructions for the use of said kit to prepare a liposomal composition useful in the treatment of a neoplasia in a mammal.