Patent ID: 7588895
Filing Date: 2009-09-15
Classification: C12Q,G01N

Abstract:
1. A method of diagnosing, or providing a prognosis for, oral tongue squamous cell carcinoma metastasis or extracapsular spread of an oral tongue squamous cell carcinoma in a human subject having the carcinoma, the method comprising the steps of: (a) contacting a biological sample comprising RNA wherein the sample is from the primary cancer site of the oral tongue squamous cell carcinoma with (b) determining whether or not RNA representing each of the CTTN, MMP9, and EGFR marker nucleic acids is overexpressed in the sample when compared to, respectively, RNA expression levels representing each of the CTTN, MMP9, and EGFR marker nucleic acids of a comparison population of human subjects having a tongue squamous cell carcinoma which did not metastasize; wherein the overexpression of the RNA representing each of the CTTN, MMP9, and EGFR marker nucleic acids in the sample indicates that the metastasis or extracapsular spread is present or likely to develop.