Patent ID: 6350763
Filing Date: 2002-02-26
Classification: C07D,C07F

Abstract:
A compound of the formula I wherein:Y is an oxygen atom; Z is an oxygen atom; X is a divalent group of the formula >NR1, R1 is: (A) a hydrogen atom, (B) methyl or ethyl, or (C) â€”COCH3 R2 is: â€ƒ(A) a hydrogen atom, or (B) methyl; R3 is a group of the formula â€”CH2R41, wherein R41 is â€ƒphenyl â€ƒwherein one or more of the hydrogen atoms of said phenyl group are â€ƒnecessarily and independently replaced with: (A) R62, which is aryl selected from the class consisting of phenyl, or pyridyl, wherein one or more of the hydrogen atoms of said aryl group may be optionally and independently replaced with: (i) methyl, (ii) a group of the formula â€”COOR63, wherein R63 is methyl, (iii) a group of the formula â€”OR68, wherein R68 is a hydrogen atom or methyl, or (iv) halogen, (B) methyl, which may be mono- or polysubstituted with fluorine atoms or which may be monosubstituted with R62, (C) a group of the formula â€”COOR73, wherein R73 is methyl, (D) a group of the formula â€”COR78, wherein R78 is methyl or R62, (E) a group of the formula â€”OR79, wherein R79 is a hydrogen atom, methyl or R62, (F) cyano, (G) nitro, or (H) halogen; R4 is Cl or trifluoromethyl; and, R6 is Cl or trifluoromethyl; or a pharmaceutically acceptable salt thereof.