Patent ID: 9056129
Filing Date: 2015-06-16
Classification: A61K,B82Y

Abstract:
1. A set of functionalized nanoparticles for the diagnosis or treatment of a medical condition, each nanoparticle comprising two or more distinct sets of functional moieties, each set of functional moieties comprising a distinct functional moiety covalently attached to the nanoparticle by a distinct linker, wherein each linker comprises a first half-linker and a second half-linker; wherein the first half-linker is covalently bound to the nanoparticle through a first reactive group on the first half-linker, and is covalently bound to a third reactive group on the second half-linker through a second reactive group on the first half-linker, and the second half-linker is covalently bound to the functional moiety through a fourth reactive group on the second half-linker; wherein the second reactive group and third reactive group react as a cross-reacting pair to form the linker; and wherein each set of functional moieties comprises a distinct cross-reacting pair of second and third reactive groups, wherein the functional moieties are selected from the group consisting of a tracking moiety, a delivery moiety, and an effector moiety; and wherein said distinct functional moieties are present on the nanoparticles in a compositional stoichiometry whose variance is less than 5% over the set of functionalized nanoparticles.