Patent ID: 6495171
Filing Date: 2002-12-17
Classification: A61K,A61P,A61Q

Abstract:
A bath medicine composition, comprising:(a) at least one ingredient selected from the group consisting of cedrol, patchouli alcohol, vetiverol, and combinations thereof; and (b) at least one intercellular corneum lipid selected from the group consisting of ceramide analogues having the following formulas (1)-(4): wherein R1 represents a linear or branched alkyl or alkenyl group having 10 to 26 carbon atoms, R2 represents a linear or branched alkyl or alkenyl group having 9 to 25 carbon atoms, and n stands for an integer of from 2 to 6; wherein R3 and R4 are the same or different and each independently represents a hydroxylated or unhydroxylated, linear or branched alkyl or alkenyl group having 1 to 40 carbon atoms, R5 represents a linear or branched alkylene group having 1 to 6 carbon atoms or a single bond, and R6 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms or a 2,3 dihydroxypropyloxy group with a proviso that R6 is a hydrogen atom when R5 is a single bond; wherein R7 represents a linear or branched alkyl or alkenyl group having 8 to 24 carbon atoms, and R8 represents a hydrocarbon group having 3 to 30 carbon atoms; wherein R9 represents a hydroxylated or unhydroxylated, phosphorylated or unphosphorylated, or sulfated or unsulfated aliphatic hydrocarbon group having 1 to 49 carbon atoms, or a fatty acid residual group having 14 to 22 carbon atoms and represented by a substituent group â€”(CaHb)â€”Oâ€”Y in which Y represents a hydrogen atom or an aliphatic hydrocarbon group represented by the following formula: wherein Z represents â€”OH, â€”OP1, â€”OSO331  or an epoxy oxygen, x stands for an integer of from 12 to 20, y stands for an integer of 20 to 40, and z stands for an integer of from 0 to 4, a stands for an integer of from 7 to 49, and b stands for an integer of from 10 to 98; R10 represents a hydroxylated or unhydroxylated, phosphorylated or unphosphorylated, or sulfated or unsulfated aliphatic hydrocarbon group having 1 to 28 carbon atoms; R11 represents a hydrogen atom, a carbohydrate group, a sulfate group or a phosphate group P1 in which P1 represents the following group: R12 represents a hydrogen atom or the following substituent group: wherein X1, X2 and X3 each independently represent a hydrogen atom or a hydroxylated or unhydroxylated alkyl group having 1 to 5 carbon atoms, c stands for an integer of from 0 to 4, d stands for an integer of 0 or 1, and R11 has the same meaning as defined above; and l and m each independently stand for 0 or 1 with the proviso that l+m is 1 or 2 when R9 has 9 to 49 carbon atoms.