Patent ID: 7101893
Filing Date: 2006-09-05
Classification: A61K,A61P,C07D

Abstract:
1. A method of treatment of hyperproliferative disorders, wherein the hyperproliferative disorder is breast cancer, head cancer, neck cancer, gastrointestinal cancer, leukemia, ovarian cancer, bronchial cancer, lung cancer, pancreatic cancer, sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, adenoid cystic carcinoma, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, or prostate carcinoma comprising a step of administering an effective amount of a compound represented by Formula II, or a pharmaceutically acceptable salt thereof: wherein: R11 is aryl, optionally is substituted with 1–6 independent halogen; hydroxy; nitro; amino; acyl; substituted acyl; acylC R21 is hydrogen; R31 is hydrogen; R R A is NH; E is C X is S; and Y is N.