Patent ID: 8101160
Filing Date: 2012-01-24
Classification: A61K,A61P

Abstract:
1. A formulation for use in an inhaler device, comprising carrier particles in the form of an agglomerate consisting of a plurality of crystals fused to one another, wherein the carrier particles have a diameter of at least 50 μm and a mass median aerodynamic diameter of at least 175 μm and a fissured surface in which the fissures between the crystals of the agglomerate are at least 20 μm wide and at least 20 μm deep; fine particles consisting of an excipient material consisting of one or more crystalline sugars and having a mass median aerodynamic diameter of not more than 20 μm; and active particles; wherein the fine excipient particles are present in an amount of from not less than 5% by weight based on the total weight of the formulation, to 50% by weight based on the total weight of the carrier particles, fine excipient particles and active particles.