Patent ID: 6762178
Filing Date: 2004-07-13
Classification: C07C,C07D,C07F

Abstract:
Hydroxamic acids having the formula: where the C(&boxH;O)NHOH moiety and the â€”NR5â€” moiety are bonded to adjacent carbons of group A;wherein A is phenyl, naphthyl, or phenyl fused to a 5 to 7 membered saturated or unsaturated cycloalkyl ring, a 5 to 9 membered saturated or unsaturated heterocycloalkyl ring having 1 or 2 heteroatoms selected from N, NR9, O or S, or a heteroaryl ring having 5-10 members and from 1-3 heteroatoms selected from N, NR9, O or S; X is SO2 or â€”P(O)R10; Y is phenyl, naphthyl or heteroaryl, with the proviso that X and Z may not be bonded to adjacent atoms of Y; Z is O, NH, CH2 or S; R5 is hydrogen or alkyl of 1-6 carbon atoms; or R5â€”Nâ€”Aâ€”, can form a benzazepine, benzoxazepine, benzothiazepine, benzodiazepine, benzazocine, benzodiazocine, benzoxazocine or benzothiazocane ring which may be optionally fused to another benzene ring; R6 and R7 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, â€”CN, â€”CCH; and R8 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, phenyl, naphthyl, 5 to 10 membered heteroaryl having from 1 to 3 heteoatoms selected from N, NR9, O or S, or 5 to 9 membered heterocycloalkyl having 1 or 2 heteroatoms selected from N, NR9, O or S; R9 is hydrogen, phenyl, naphthyl, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-6 carbon atoms; and R10 is phenyl, naphthyl, alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, 5 to 10 membered heteroaryl having from 1 to 3 heteoatoms selected from N, NR9, O or S, or 5 to 9 membered heterocycloalkyl having 1 or 2 heteroatoms selected from N, NR9, O or S; or a pharmaceutically acceptable salt thereof; with the proviso that Y must be heteroaryl if A is phenyl, naphthyl, or phenyl fused to a 5 to 7 membered saturated or unsaturated cycloalkyl ring and R5 is hydrogen or alkyl of 1-6 carbon atoms and R8 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, phenyl, or naphthyl and R10 is phenyl, naphthyl, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-6 carbon atoms.