Patent ID: 8580548
Filing Date: 2013-11-12
Classification: A61K,C12N,C12P,C12Y

Abstract:
1. An isolated reverse transcriptase having an optimum activity at a temperature above 42° C., wherein the optimum activity at a temperature above 42° C. is an increased activity of the isolated reverse transcriptase compared to the activity of the isolated reverse transcriptase at 37° C., and wherein the reverse transcriptase comprises SEQ ID NO: 25 with at least one mutation selected from the group consisting of D200Q; D200V; D200 W; D200K; L603W; L603F; D653K; D653H; D200N, L603W; D200N, L603W, T330P; D200N, L603W, T330P, E607K; D200N, L603W, T330P, E607K, L139P; D200N, L603W, N479D, H594R; D200N, L603W, D653N, D524G; and D200N, L603W, D653N, D524G, T330P.