Patent ID: 6426364
Filing Date: 2002-07-30
Classification: A61P,C07C,C07D

Abstract:
A compound of Formula I: wherein:Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of alkyl, alkoxy, cycloalkyl, cycloalkyloxy, alkanoyl, thioalkyl, aralkyl, aralkyloxy, aryloxyalkyl, aryloxyalkoxy, cycloalkyl-substituted alkyl, cycloalkyloxy-substituted alkyl, cycloalkyl-substituted alkoxy, cycloalkyloxy-substituted alkoxy, thioaryl, aralkylthio, thioaryl-alkyl, aralkylthioalkyl, halo, NO2, CF3, CN, OH, alkylenedioxy, SO2NRRâ€², NRRâ€², CO2R (where R and Râ€² are independently selected from the group consisting of H and alkyl), and a second aryl group, which may be substituted as above, wherein the aryls of the substitutions are carbocyclic; R1 is selected from the group consisting of H and alkyl; R2 is selected from the group consisting of H, alkyl and benzyl; R3 is selected from the group consisting of CO2R, CONRRâ€², CONH(OH), COSR, SO2NRRâ€², PO(OR)(ORâ€²) and tetrazolyl, wherein R and Râ€² are independently selected from the group consisting of H and alkyl; and a salt, solvate or hydrate thereof.