Patent ID: 6214385
Filing Date: 2001-04-10
Classification: A61K

Abstract:
A once-a-day controlled absorption diltiazem pellet formulation for oral administration comprising a blend of long lag and short lag pellets, where the long lag pellets comprise:1) a core comprising an effective amount of diltiazem or a pharmaceutically acceptable salt, the core being substantially free of organic acid;2) and the long lag pellets substantially exhibit the following dissolution profile when measured according to U.S. Pharmacopeia XXII in a type 2 dissolution apparatus at 37.degree. C. in 0.1N HCl at 100 rpm:a) 0-10% of the diltiazem is released after 2 hours;b) 0-10% of the diltiazem is released after 4 hours;c) 0-15% of the diltiazem is released after 6 hours;d) 0-15% of the diltiazem is released after 8 hours and;e) more than 60% of the diltiazem is released after 18 hours.