Patent ID: 6054488
Filing Date: 2000-04-25
Classification: A61K

Abstract:
A pharmaceutical suspension formulation suitable for aerosol administration, consisting essentially of:(a) from 0.0025 to 0.1% w/w of micronized formoterol, or an acid addition salt thereof and(b) from 0.1 to 5.0% w/w ethanol,(c) HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a and optionally(d) a surfactant other than a monoacetylated or diacetylated monoglyceride,the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.