Patent ID: 8084467
Filing Date: 2011-12-27
Classification: C07D

Abstract:
1. A compound of formula I below, and physiologically acceptable salts, comprising: wherein: A is selected from a direct bond; B is selected from N; R1 is —(CH R1 is —(CH R1 is —(CH R1 is —(CH R2 is selected from a carbocyclic ring having 4 to 7 members, a heterocyclic ring having 4 to 7 members, a heteroaromatic ring having 5 to 7 members, naphthyl, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or R2 is selected from R3 is selected from H, halogen, CN, alkyl, alcohol, or alkylmercapto; or R3 is selected from —CH(OH)CH R3 is a branched or unbranched, saturated or unsaturated, carbon chain having 1 to 10 carbon atoms, and substituted in any possible position with one or more members independently selected from H, alkyl, alcohol, or alkylmercapto; or R R3 is selected from —CH R4 is —(CH R4 is —(CH R4 is -T-(CH R4 is -T-(CH R4 is -T-(CH R4 is -T-(CH R4 is -T-(CH R4 is -Ph-(CH R4 is -Ph-(CH R4 is -Ph-(CH R4 is -Ph-(CH R4 is -Ph-(CH R4 is -Ph-(CH with the proviso that when A is a direct bond and B is N and R5 is hydrogen and R2 has a nitrogen directly connected to the nitrogen of the amide at the 3-position of pyrazole ring, then R4 can not be a phenyl ring or a phenyl ring having one to three substitutions selected from halogen, trifluoromethyl, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, lower-alkyl substituted 1-pyrrolidinyl, lower-alkyl substituted 1-piperidinyl, lower-alkyl substituted 4-morpholinyl, and lower-alkyl substituted 1-piperazinyl; when A is a direct bond and B is N then R1 cannot be H; when A is not a direct bond and B is N then R3 cannot be H or a C1-C3 alkyl; when A is a direct bond and B is N and R1 is a 6 member aromatic ring having 0 to 3 substituents independently selected from halogen, fluoromethyl and trifluoromethyl then R4 cannot be a 6 member aromatic ring having 0 to 3 substituents independently selected from halogen, fluoromethyl and trifluoromethyl; when A is a direct bond and B is N and R5 is hydrogen and R2 has a nitrogen directly connected to the nitrogen of the amide at the 3-position of pyrazole ring, then R4 can not be a phenyl ring or a phenyl ring having one to three substitutions selected from halogen, trifluoromethyl, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, lower-alkyl substituted 1-pyrrolidinyl, lower-alkyl substituted 1-piperidinyl, lower-alkyl substituted 4-morpholinyl, and lower-alkyl substituted 1-piperazinyl.