Patent ID: 9115385
Filing Date: 2015-08-25
Classification: A61K,A61P,C12Q,G01N

Abstract:
1. A method for determining the amount of topoisomerase I phosphorylated at amino acid residue serine 506 in a cancer cell, comprising: (i) obtaining a sample comprising at least one cancer cell; (ii) measuring the amount of phosphorylation on topoisomerase I amino acid residue serine 506 by contacting the sample of step (i) with an antibody that binds SEQ ID NO:7; (iii) measuring the amount of a control protein by contacting the sample of step (i) with an antibody that binds the control protein; and (iv) determining the amount of topoisomerase I phosphorylated at amino acid residue serine 506 by comparing the amount of step (ii) with the amount of step (iii).