Patent ID: 8993349
Filing Date: 2015-03-31
Classification: B82Y,C07K,G01N

Abstract:
1. A composition, comprising a micelle dispersed in aqueous solution, wherein the micelle comprises: (a) one or more semiconductor nanoparticles encapsulated with a negatively charged amphiphilic polymer, wherein the amphiphilic polymer is a block copolymer or grafted polymer that comprises at least one hydrophilic segment and at least one hydrophobic segment that encapsulates the one or more semiconductor nanoparticles through hydrophobic interaction, and (b) a cationic polypeptide comprising 5 to 25 contiguous lysine and/or arginine residues, wherein the cationic polypeptide is associated with the at least one hydrophilic segment of the amphiphilic polymer; wherein the micelle is capable of enhancing the transport of the one or more semiconductor nanoparticles across a biological membrane.