Patent ID: 6140328
Filing Date: 2000-10-31
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR6## wherein R.sub.1, R.sub.2 and R.sub.3 are each individually hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy, or halo; or R.sub.1 and R.sub.2 taken together are methylenedioxy and R.sub.3 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy, or halo; or R.sub.2 and R.sub.3 taken together are methylenedioxy and R.sub.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy or halo;R.sub.4 is oxy, (C.sub.1 -C.sub.6)alkyl, or is absent;R.sub.5 is hydrogen, hydroxy, or (C.sub.1 -C.sub.6)alkyl;R.sub.6, R.sub.7 and R.sub.8 are each individually hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy, or halo; or R.sub.6 and R.sub.7 taken together are methylenedioxy and R.sub.8 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy, or halo; or R.sub.7 and R.sub.8 taken together are methylenedioxy and R.sub.6 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, hydroxy or halo;each bond represented by ----- is individually present or absent;X is C(R.sub.a)(R.sub.b) or NR.sub.c ;Y is C(R.sub.d)(R.sub.e) or NR.sub.f ;if present, R.sub.a and R.sub.b are each independently hydrogen or (C.sub.1 -C.sub.6)alkyl if the bond between the 11- and 12-positions represented by ----- is absent; or R.sub.a is hydrogen or (C.sub.1 -C.sub.6)alkyl and R.sub.b is absent if the bond between the 11- and 12-positions represented by ----- is present;if present, R.sub.c and R.sub.f are each independently hydrogen or (C.sub.1 -C.sub.6)alkyl if the bond between the 11- and 12-positions represented by ----- is absent; or R.sub.c and R.sub.f are each absent if the bond between the 11- and 12-positions represented by ----- is present; andif present, R.sub.d and R.sub.e are each independently hydrogen or (C.sub.1 -C.sub.6)alkyl if the bond between the 11- and 12-positions represented by ----- is absent; or R.sub.d is hydrogen or (C.sub.1 -C.sub.6)alkyl and R.sub.e is absent if the bond between the 11- and 12-positions represented by ----- is present;provided that R.sub.2 and R.sub.8 are not both (C.sub.1 -C.sub.6)alkoxy;provided that R.sub.1 -R.sub.3 and R.sub.6 -R.sub.8 are not all hydrogen;provided the compound is not 9-methylbenzol[i]phenanthridine; 1-chloro-2-methoxybenzo[i]phenanthridine; 2-methoxybenzo[i]phenanthridine; 2,3-methylenedioxy-8,9-methylenedioxybenzo[i]phenanthridine; 5,8-dimethylbenzo[i]phenanthridine; 2-methoxy-5-methylbenzo[i]phenanthridine;2-methoxy-5,8-dimethyl benzo[i]phenanthridine; 5,6-dihydro-9-methyl-benzo[i]phenanthridine; or 1-chloro-2-methoxy-5,6-dihydrobenzo[i]phenanthridine;or a pharmaceutically acceptable salt thereof.