Patent ID: 7498324
Filing Date: 2009-03-03
Classification: A61P,C07D

Abstract:
1. A process for preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof, comprising, according to a scheme as depicted below, in step 1, an amino acid coupling of a beta-hydroxy acid X with a W-X-Y-Z substituted aminolactam XI to form a lactam XII by reacting TBTU in DMF with a base, NMM; followed, in step 2, reacting the lactam XII with thiocarbonyl diimidazole to form a compound of formula XIII which is in step 3 converted to a compound of Formula (Ia′) by a radical reduction; and optionally, in step 4, deprotonate the amide bond in compound formula (Ia′) by a reaction with R6-LG where LG is a leaving group to form a compound of Formula (I′): wherein: Q′ is Q Q is —(CR m is 1, 2, or 3; n is 0, 1, or 2; R R R R R R R R R R R R Ring B is R R R W is a bond or —(CR p is 0, 1, 2, 3, or 4; R X is a bond; R Y is a bond or —(CR t is 0, 1, or 2; u is 0, 1, or 2; R V is a bond, —C(═O)—, —O—, —S—, —S(═O)—, —S(═O) Z is H; R R R R R R R alternatively, R R R R R R R R