Patent ID: 6316432
Filing Date: 2001-11-13
Classification: A61P,C07J

Abstract:
A 17.alpha.-Fluoroalkyl steroid of general formula I ##STR5##in whichR.sup.1 stands for a methyl or ethyl group,R.sup.2 stands for a radical of formula C.sub.n F.sub.m H.sub.o wherein n is 2, 3, 4, 5 or 6, m>1 and m+o=2n+1,R.sup.3 stands for a free, etherified or esterified hydroxy group,R.sup.4 and R.sub.5 each stand for a hydrogen atom, together form an additional bond or a methylene group,St stands for a steroidal ABC-ring system of partial formula A, B or C ##STR6##in whichR.sup.6 means a hydrogen atom, a straight-chain C.sub.1 -C.sub.4 alkyl group or branched C.sub.3 -C.sub.4 alkyl group or a halogen atom,R.sup.7 means a hydrogen atom, a straight-chain C.sub.1 -C.sub.4 alkyl gyroup or a branched C.sub.3 -C.sub.4 alkyl group, orif St stands for a steroidal ABC-ring system A or B, in additionR.sup.6 and R.sup.7 together mean an additional bond,X means an oxygen atom, a hydroxyimino grouping .dbd.N--OH or two hydrogen atoms,R.sup.8 means a radical Y wherein Y is a hydrogen atom, a halogen atom, an --OH, --NO.sub.2, --N.sub.3, --CN, --NHSO.sub.2 R.sup.9, --CO.sub.2 R.sup.9, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, C.sub.1 -C.sub.10 alkanoyloxy, benzoyloxy, C.sub.1 -C.sub.10 alkanoyl, C.sub.1 -C.sub.10 hydroxyalkyl or benzoyl group, or R.sup.8 means an aryl radical that is optionally substituted with Y', wherein Y' is a hydrogen atom, a halogen atom, an --OH, --NO.sub.2, --N.sub.3, --NR.sup.9a R.sup.9b, --CN, --NHSO.sub.2 R.sup.9, --CO.sub.2 R.sup.9, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, C.sub.1 -C.sub.10 alkanoyloxy, benzoyloxy, C.sub.1 -C.sub.10 alkanoyl, C.sub.1 -C.sub.10 hydroxyalkyl or benzoyl group, and R.sup.9a and R.sup.9b are the same or different and represent a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group, and R.sup.9 is a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group,or for a --NR.sup.9a R.sup.9b radical, also a physiologically compatible salt thereof with an acid, or for a --CO.sub.2 R.sup.9 radical in which R.sup.9 is hydrogen, also a physically compatible salt thereof with a base.