Patent ID: 6075012
Filing Date: 2000-06-13
Classification: A61K

Abstract:
A compound having the structure: and salts thereof where:R is R.sub.A or R.sub.B, where R.sub.A is a C.sub.1-23 alkyl or alkenyl group and R.sub.B is a steroid selected from the group consisting of stigmasterol, ergosterol and cholic acid;m is 1;A is selected from any of A.sub.1 -A.sub.2 where:A.sub.1 is ##STR20## where --D.sub.A is bonded to R and --E is bonded to Z; R"", independently of R, is R.sub.A or R.sub.B, where R.sub.A is a C .sub.1-23 alkyl or alkenyl group and R.sub.B is a steroid selected from the group consisting of stigmasterol, ergosterol and cholic acid;D.sub.A and D.sub.B, independently of one another, are selected from the group consisting of D.sub.1 and D.sub.2 where:D.sub.1 is --Y.sub.1 --CO--Y.sub.2 --, where Y.sub.1 and Y.sub.2, independently of one another, are O or NH, and wherein at least one of Y.sub.1 and Y.sub.2 is NH; andD.sub.2 is --CH.dbd.CH--O--;E is selected from the group consisting of E.sub.1 -E.sub.3 where:E.sub.1 is ##STR21## where W.sub.1 and W.sub.2, independently of one another, are C.sub.1-24 alkyl, alkenyl or aryl; and q is 1 to 6;E.sub.2 is --PO.sup.-.sub.4 --(CH.sub.2).sub.2 --NH--;E.sub.3 is --(PO.sup.-.sub.4).sub.r --NH--, where r is 1 or 2:A.sub.2 is ##STR22## where B.sub.A -B.sub.C, independently of one another, are selected from the group consisting of B.sub.1 -B.sub.4, where at least one of B.sub.A -B.sub.C is B.sub.3 or B.sub.4, and B.sub.3 or B.sub.4 are bonded to Z, which is Z.sub.14, and --CH is bonded to R, whereB.sub.1 is --OH;B.sub.2 is --NH--R', where R' is a C.sub.1-23 alkyl, alkenyl or acyl group;B.sub.3 is --O-- or --NH--; andB.sub.4 is --PO.sub.4.sup.- --(CH.sub.2).sub.2 --NH--;where Z is selected from the group consisting of Z.sub.1 -Z.sub.15, Z.sub.18 whereZ.sub.1 is H;Z.sub.2 is --(CH.sub.2).sub.n --X, where n is 1-24 and X is selected from the group consisting of Br, Cl, I and F;Z.sub.3 is --(CH.sub.2).sub.n --NH.sub.2, n=1-24;Z.sub.4 is --CH.sub.2 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.4 --NH.sub.2 ;Z.sub.5 is --CH.sub.2 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH.sub.2 ;Z.sub.6 is --CH.sub.2 --NH--(CH.sub.2).sub.n --NH.sub.2, n=2-24;Z .sub.7 is --L--X where L is selected from the group consisting of branched or straight chain alkyl, alkenyl, cycloalkyl, aryl, alkoxy, thioalkyl and thioether groups having from 1 to about 24 carbon atoms, and X is selected from the group consisting of Br, Cl, I, F, NH.sub.2 and [(NH.sub.2)--(CH.sub.2).sub.n ].sub.m where n is 2-24 and m is 1-24; ##STR23## where n=1-24, D is H or other groups attached by amide or alkyl amino groups;Z.sub.10 is a reporter molecule;Z.sub.11 is a protein, a peptide or polypeptide;Z.sub.12 is a polysaccharide;Z.sub.13 is an amine or halide reactive group; ##STR24## n=1-24, D is H or other groups attached by amide or alkyl amino groups; andZ.sub.18 is a nucleic acid binding substance.