Patent ID: 6534517
Filing Date: 2003-03-18
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein ring A and ring B, fused to the ring containing X and T, independently of each other represents aryl or pyridyl, optionally substituted with oxadiazolyl, wherein the oxadiazolyl can be substituted with C1-4-alkyl;X is a valence bond; T is N; Y is C; k is 1 or 2; &boxH; represents a single or a double bond; Ar is arylene, heteroarylene, or a divalent heterocyclic group each of which can optionally be substituted with one or more halogen,C1-6-alkyl, amino, hydroxy, C1-6-alkoxy or aryl; R1 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; R2 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R2 forms a bond together with R3; R3 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, acyl or arylalkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R3 forms a bond together with R2; R4 is hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylalkyl heterocyclyl, heteroaryl or heteroarylalkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; R5 is hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylalkyl, heterocyclyl, heteroaryl or heteroarylalkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; Z is oxygen or NR12, wherein R12 represents hydrogen C1-12-alkyl, aryl, hydroxyC1-12-alkyl or arylalkyl groups or when Z is NR12, R4 and R12 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6alkyl; Q is oxygen or NR13, wherein R13 represents hydrogen C1 12-alkyl, aryl, hydroxyC1-12-alkyl or arylalkyl groups or when Q is NR13, R5 and R13 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6-alkyl; n is an integer ranging from 0 to 3; m is an integer ranging from 0 to 1; p is an integer ranging from 0 to 1; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms.