Patent ID: 7416860
Filing Date: 2008-08-26
Classification: A01K,A61P,C12N,C12Y

Abstract:
1. A recombinant nucleic acid construct comprising a nucleotide sequence encoding a human coagulation Factor VII variant of SEQ ID NO:1, except for a substitution of the Leu in position 305 of SEQ ID NO:1 with an amino acid residue selected from the group consisting of Val, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, Asn, Glu, Lys, Arg, His, Asp and Gln and wherein the ratio between the activity of the variant to the activity of native Factor VII polypeptide having the sequence shown in SEQ ID NO: 1 is at least about 1.25 when tested in an in vitro hydrolysis assay.