Patent ID: 6303569
Filing Date: 2001-10-16
Classification: A61K,A61P,C07B,C07C

Abstract:
A compound comprising the formula: ##STR30##wherein:B is H, OH, OSiR.sub.13, a residue of an amine-containing target moiety or a residue of a hydroxyl-containing moiety;L.sub.1 and L.sub.2 are bifunctional linking moieties;Y.sub.2 is O or S;R.sub.2 is selected from the group consisting of C.sub.1-6 alkyls, C.sub.3-12 branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted alkyls, C.sub.3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C.sub.1-6 heteroalkyls, substituted C.sub.1-6 heteroalkyls, C.sub.1-6 alkoxy, phenoxy, and C.sub.1-6 heteroalkoxy;R.sub.9, R.sub.10, and R.sub.13 are independently one of hydrogen, C.sub.1-6 alkyls, C.sub.3-12 branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted alkyls, C.sub.3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C.sub.1-6 heteroalkyls, substituted C.sub.1-6 heteroalkyls, C.sub.1-6 alkoxy, phenoxy, and C.sub.1-6 heteroalkoxy;Ar is a moiety which when included in Formula (I) forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group;(m) is zero or one; andR.sub.11 is a polymer residue;except that ##STR31##when L.sub.1 is ##STR32##and L.sub.2 is ##STR33##whereinM is X or Q; wherein X is an electron withdrawing group, and Q is a moiety containing a free electron pair positioned three to six atoms from C(--Y.sub.2);(n) is zero or a positive integer;G is ##STR34##where Y.sub.1 is O or S, or CH.sub.2 ;(p) is zero, one or two;R.sub.1, R.sub.4, R.sub.7 and R.sub.8 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyls, C.sub.3-12 branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted alkyls, C.sub.3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C.sub.1-6 heteroalkyls and substituted C.sub.1-6 heteroalkyls;R.sub.3, R.sub.5 and R.sub.6 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyls, C.sub.1-6 alkoxy, phenoxy, C.sub.1-8 heteroalkyls, C.sub.1-8 heteroalkoxy, C.sub.1-6 substituted alkyls, C.sub.3-8 cycloalkyls, C.sub.3-8 substituted cycloalkyls, aralkyls, aryls; aryls substituted with a member of the group consisting of halo-, nitro- and cyano-; carboxy-, C.sub.1-6 carboxyalkyls and C.sub.1-6 alkyl caibonyls.