Patent ID: 6455676
Filing Date: 2002-09-24
Classification: A61K,A61P,C07K

Abstract:
A hemoglobin mutant with reduced rate of reaction with nitric oxide selected from the following mutation in the alpha subunit:E11(Valâ†’Leu) and E7(Hisâ†’Gln); E11(Valâ†’Phe or Trp) and E7(Hisâ†’Gln); E11(Valâ†’Phe or Trp or Leu) and E7(Hisâ†’Gln) and G8(Leuâ†’Phe or Trp); B10(Leuâ†’Phe) and E4(Valâ†’Leu); B10(Leuâ†’Trp) and E4(Valâ†’Leu); B10(Leuâ†’Trp) and E7(Hisâ†’Gln); B10(Leuâ†’Trp) and E11(Valâ†’Phe); B10(Leuâ†’Trp) and E11(Valâ†’Trp); B10(Leuâ†’Trp) and E11(Valâ†’Leu) and G8(Leuâ†’Trp); B10(Leuâ†’Trp) and E11(Valâ†’Leu) and G8(Leuâ†’Phe); B10(Leuâ†’Trp) and E11(Valâ†’Phe) and G8(Leuâ†’Trp); B10(Leuâ†’Trp) and E11(Valâ†’Phe) and G8(Leuâ†’Ilc); B10(Leuâ†’Trp) and E7(Hisâ†’Gln) and E11(Valâ†’Leu) and G8(Leuâ†’Trp); B10(Leuâ†’Trp) and E11(Valâ†’Trp) and G8(Leuâ†’Trp); E11(Valâ†’Leu) and G8(Leuâ†’Phe); E11(Valâ†’Leu) and G8(Leuâ†’Trp); B13(Metâ†’Phe or Trp); G12(Leuâ†’Phe or Trp); or B14(Pheâ†’Trp).