Patent ID: 8962284
Filing Date: 2015-02-24
Classification: C07D,C07K,C12N,C12P,C12R

Abstract:
1. A method for producing a sulfur-containing amino acid, a related substance thereof, or a mixture thereof, which comprises: culturing the bacterium belonging to the family Enterobacteriaceae, which has a sulfur-containing amino acid-producing ability and is modified so that the expression amount of the YeeE gene is increased, in a medium; and collecting a sulfur-containing amino acid, a related substance thereof, or a mixture thereof from the medium, wherein said expression amount of the yeeE gene is increased by a method selected from the group consisting of: a) increasing the copy number of the yeeE gene, b) modifying an expression control sequence of the gene, and c) combinations thereof, and wherein said yeeE gene encodes a protein selected from the group consisting of: (A) a protein comprising the amino acid sequence of SEQ ID NO: 14, and (B) a protein comprising the amino acid sequence of SEQ ID NO: 14, but which includes 1 to 10 amino acid substitutions, deletions, insertions, or additions, and wherein the increase in said protein's activity improves the ability of said bacterium to produce a sulfur-containing amino acid, and (C) a protein comprising an amino acid sequence having a homology of 90% or more to SEQ ID NO: 14.