Patent ID: 6815415
Filing Date: 2004-11-09
Classification: A61K,A61P,C07K,C12N,C12Q,C12Y,G01N

Abstract:
A method of inhibiting tumor growth comprising identifying a mammal comprising an elevated level of an HAAH polypeptide compared to a normal nonneoplastic level of said polypeptide, said HAAH polypeptide comprising an amino acid sequence of SEQ ID NO:2, and administering to said mammal a compound which inhibits tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), said IRS-1 comprising an amino acid sequence of SEQ ID NO:5, wherein said compound is dominant negative IRS-1 mutant comprising a mutation in a carboxy-terminal SH2 binding motif of SEQ ID NO:5.