Patent ID: 6794505
Filing Date: 2004-09-21
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I: wherein:R1, R2, R3, R4, R5, R6, R12, R13, R14, R15, and R16 are independently selected from hydrogen; a halogen; unsubstituted or substituted C1-C8 alkyl, C3-C6 cycloalkyl, acetyl, an unsubstituted or substituted aromatic, monovalent, monocyclic, bicyclic, or tricyclic radical comprising 6 to 18 carbon ring atoms, alkenyl, alkynyl, amide groups, or ester groups; NR17R18; vinyl; N(R17)(R18)(R19)+Zâˆ’; CH&boxH;CHNR17R18; CH2CH2NR17R18; CH&boxH;CHN(R17)(R18)(R19)+Zâˆ’; CH2CH2N(R17)(R18)(R19)+Zâˆ’; CHOHCH3; CHOR17CH3; CN; OH; OR17; CHO; CH&boxH;CHCO2R17; (CH2)nOH; (CH2)nSH; (CH2)nO-alkoxy; (CH2)nSR17; (CH2)nOR17; (CH2)nCO2R17; (CH2)nCONHR17; (CH2)nCON(R17)(R18); CO2R17; CONHR17; CONR17R18; SR17; SO3H; SO3R17; SO2NHR17; SO2N(R17)(R18); and SO2N(R17)(R18)(R19)+Zâˆ’; R15 may be additionally selected from a C5-C14 cycloalkyl, a unsubstituted or substituted aromatic, monovalent, monocyclic, bicyclic, or tricyclic radical comprising 6 to 18 carbon ring atoms, or a substituted or unsubstituted heteroaryl group selected from thienyl, pyrrolyl, imidazoloyl, pyrazolyl, furyl, isothiazolyl, furazanyl, isoxazolyl, thiazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, benzo[b]thienyl, naphtha[2,3-b]thianthrenyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathienyl, naphthylridinyl, guinoxvalinyl, quinzolinyl, benzothiazolyl, benzimidazolyl, tetrahydroauinolinyl, cinnolinyl, pteridinyl, carbazolyl, beta-carbolinyl, phenanthridinyl, acridinyl, permidinyl, phenanthrolinyl, phenazinyl, isothiazolyl, phenothiazinyl, or phenoxazinyl; R17, R18, and R19 are independently selected from hydrogen; a pharmaceutically acceptable salt; unsubstituted or substituted C1-C6 alkyl, an unsubstituted or substituted aromatic, monovalent, monocyclic, bicyclic, or tricyclic radical comprising 6 to 18 carbon ring atoms, alkenyl, or alkynyl; halogen; C1-C5 alkoxy; hydroxy; alkylhydroxy; alkylether, carboxylic acid or acid salts; carboxylic acid esters; sulfonic acid or acid salts; sulfonylamides; sulfonic acid esters; amino; cyano; nitro; amino acids; ketoses; aldoses; pyranoses; furanoses; phenylosazones; sugar alcohols; sugar acids; deoxy sugars; amino-sugars; disaccharides; trisaccharides; polysaccharides; storage polysaccharides and their O-acyl and O-methyl derivatives; ribonucleosides; 2â€²-deoxyribonucleosides; and ligands specific for a receptor; Zâˆ’ is a pharmaceutically acceptable ion; R7, R8, R9, R10, and R11 are independently selected from hydrogen, an unsubstituted or substituted alkyl, and aryl; n is an integer ranging from 1 to 4; M is two hydrogens or a metal ion selected from Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Gd, Hf, Ho, In, La, Lu, Mg, Mn, Mo, Nd, Ni, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn, and Zr; provided that when R1, R2, R3, R4, R5, R6, R8, R10, R11, R12, and R13 are hydrogen, and R9 is selected from the group consisting of hydrogen and OCH3, and M is Ni, Cu or H2, and R7 is selected from the group consisting of H, CH3, CO2-t-butyl, CO2-ethyl, CO2-isopropyl, and CO2-benzyl; then R14, R15, and R16 cannot simultaneously be C6H4X where X is selected from the group consisting of hydrogen and OCH3.