Patent ID: 6624166
Filing Date: 2003-09-23
Classification: A61P,C07D

Abstract:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: whereinR1 is halogen; R2 is OR5, NH(CHR5)mâ€”COOR5, NH(CHR5)mCON(R5)R6, N(R5)R6 or NH(CHR5)mOH; R3 is H or alkyl; R4 is: substituted phenyl or substituted or unsubstituted napthyl, and said substituents are selected from the group consisting of halo, lower alkyl, nitro, amino, acylamino, hydroxy, lower alkoxy, alkyl sulfonyl, trifluoromethyl, morpholinoethoxy, morpholinosulfonyl and carbobenzoxy-methyl sulfonyl; or heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, thiazolyl, imidazolyl, pyrazolyl, triazinyl, quinolyl and isoquinolyl; R5 and R6 are independently H, lower alkyl, substituted or unsubstituted aryl, hydroxy alkyl, amino alkyl, heteroaryl, or lower cycloalkyl; wherein said aryl is phenyl or naphthyl and said substituents are selected from the group consisting of halo, lower alkyl, nitro, amino, acylamino, hydroxy, lower alkoxy, alkyl sulfonyl, trifluoromethyl, morpholinoethoxy, morpholino-sulfonyl and carbobenzoxy-methyl sulfamoyl; and wherein said heteroaryl is selected from the group consisting of pyridyl, thienyl, furyl, thiazolyl, imidazolyl, pyrazolyl, triazinyl, quinolyl and isoquinolyl; and m is 0-6; provided that when R1 is chloro, R3 is H and R2 is NH2, R4 is not 3- or 4-pyridyl.