Patent ID: 6140316
Filing Date: 2000-10-31
Classification: C07J

Abstract:
A pharmaceutical composition in a dosage unit form adapted for nasal administration in a human subject, said composition comprising per dosage unit, an effective amount of an Estrene steroid in a range to effect the nervous system through the vomeronasal organ but ineffective to have a systemic effect by absorption into the circulatory system and a pharmaceutically acceptable carrier, wherein said Estrene steroid has the formula ##STR73## wherein R.sub.1 is selected from the group consisting of one or two hydrogen atoms, methyl, methylene, and one or two halo atoms; R.sub.2 is absent or is selected from the group consisting of hydrogen and methyl; R.sub.3 is selected from the group consisting of oxo, hydroxy, lower alkoxy, lower acyloxy, benzoyl, cypionyl, glucouronide and sulfonyl; R.sub.4 is selected from the group consisting of hydrogen, hydroxy, lower alkoxy, lower acyloxy and halo; R.sub.5 is absent or is selected from the group consisting of hydrogen, hydroxy, lower alkoxy and lower acyloxy; R.sub.6 is a hydrogen or a halo; and ""a"" represents optional aromatic unsaturation of ring A of said steroid, or ""b"", ""c"", and ""d"" are each optional double bonds; and ""e"", ""f"", ""g"", ""h"", ""i"" and ""j"" are each optional double bonds;wherein: ""h"" and ""i"" are both double bonds; or ""j"" is a double bond; or ""c"" and ""d"" are double bonds; or ""f"" is a double bond.