Patent ID: 6060484
Filing Date: 2000-05-09
Classification: A61K,A61P,C07C,C07D

Abstract:
A method of treating or preventing a viral infection where the virus is an envelope virus that undergoes hemagglutinin-mediated fusion with a host cell which comprises administering to a virus-infected cell, a cell susceptible of infection or a mammal in need thereof an effective amount of a compound of formula I: ##STR21## wherein: a is 1, 2 or 3;X is a bond, --NH--, --CH.sub.2 --, --O-- or --S--;Y is oxygen, sulfur or nitrogen;R is halo or C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;X.sup.1 is --O--, --N(R.sup.1)-- or --CH.sub.2 --;R.sup.0 is a group of the formula: ##STR22## where: R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl or pyridyl (C.sub.1 -C.sub.4 alkyl) , thienyl (C.sub.1 -C.sub.4 alkyl) or furyl (C.sub.1 -C.sub.4 alkyl);each b, d and f are independently 1, 2 or 3;c is 0, 1 or 2;R.sup.2 and R.sup.3 are independently hydrogen, phenyl, pyridyl, thiazolyl, quinolyl, tetrahydroquinolyl, cyclohexyl, cyclohexenyl or phenyl or pyridyl substituted with halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;R.sup.4 is hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl;R.sup.5 is hydrogen or R.sup.5 and R.sup.6 combine to form a bond;R.sup.6 and R.sup.7 are independently hydroxy, --OC(O)CH.sub.3, .dbd.O, --OC(O)NHR.sup.6a, --O--(R.sup.6b).sub.x -- or R.sup.6 and R.sup.7 combine to form a bond;R.sup.6a is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl;R.sup.6b is an amino acid;x is 1, 2 or 3;R.sup.8 and R.sup.9 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;with the proviso that when R.sup.5 and R.sup.6 combine to form a bond, R.sup.7 must be hydrogen, and when R.sup.6 and R.sup.7 combine to form a bond, R.sup.5 must be hydrogen;or a pharmaceutically acceptable salt thereof.