Patent ID: 8513244
Filing Date: 2013-08-20
Classification: A61K,A61P,C07D

Abstract:
1. A compound of formula I: where: R R R R —C 1-3 alkylene-C(O)OR 40 ; —CH 2 —C(O)NR 41 R 42 ; —C 0-2 alkylene-pyridine optionally substituted with halo; —CH 2 -isoxazole optionally substituted with methyl; —CH 2 -pyrimidine optionally substituted with —O—C 1-6 alkyl; —C 2 alkylene-phenyl; R R R 13 is selected from —C 1-6 alkyl, —O—C 1-6 alkyl, —C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 14 R 15 , and —CH(NH 2 )CH 2 COOCH 3 ; R- 14 and R 15 are independently selected from H, —C 1-6 alkyl, and benzyl, or R 14 and R 15 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 O(CH 2 ) 2 —; R 16 is —C 1-6 alkyl or —C 0-6 alkylene-C 6-10 aryl; R 17 is selected from —O—C 1-6 alkyl, —O-benzyl, and —NR 14 R 15 ; R R R R R R R or a pharmaceutically acceptable salt thereof.