Patent ID: 6417326
Filing Date: 2002-07-09
Classification: A61K,C07K,C12N

Abstract:
A lipopeptide, said lipopeptide comprising:a lipid covalently attached to a fusion peptide by means of an amide bond, wherein said amide bond is formed from a lipid having a carboxyl group and an amino group from said fusion peptide, wherein said lipid is a diacyglycerol, and wherein said fusion peptide is a member selected from the group consisting of Ac-GLFEAIAGFIENGWEGMIDGK (SEQ ID NO:3); WEAALAEALAEALAEHLAEALAEALEALAA (SEQ ID NO:4); GGYCLTRWMLIEAELKCFGNTAV (SEQ ID NO:5); GGYCLTKWMILAAELKCFGNTAV (SEQ ID NO:6); GGYCLEKWMIVASELKCFGNTA (SEQ ID NO:7); GGYCLEQWAIIWAGIKCFDNTVM (SEQ ID NO:8); GLFEALAEFIEGGWEGLIEG; (SEQ ID NO:9); GLFEAIAEFIEAIAEFIEG (SEQ ID NO:10); GWEGLIEGIEGGWEGLIEG (SEQ ID NO:11); GLFEAIAEFIPGGWEGLIEG (SEQ ID NO:12); GLLEELLELLEELWEELLEG (SEQ ID NO:13); Ac-LARLLARLLARL-NHCH3 (SEQ ID NO:14); Ac-LARLLPRLLARL-NHCH3 (SEQ ID NO:15); Ac-LPRLLPRLLARL-NHCH3 (SEQ ID NO:16); Ac-LPRLLPRLLPRL-NHCH3 (SEQ ID NO:17); FEAALAEALAEALA (SEQ ID NO:18); Myr-FEAALAEALAEALA (SEQ ID NO:19); WEAALAEALAEALAC (SEQ ID NO:20); poly(Glu-Aib-Leu-Aib) (SEQ ID NO:21); wherein: Myr represents myristic acid; and Aib represents 2-aminoisobutyric acid; and and conservative modifications thereof.