Patent ID: 6815553
Filing Date: 2004-11-09
Classification: C07C,C07D,C07J,D21B

Abstract:
A process for obtaining lupeol, betulinic acid and betulin from outer birch bark comprising:extracting with carbon dioxide; at least one of Xe, Freon-23, ethane, N2O, SF6, propane, ammonia, and n-C4H10, (C2H5)2O; at least one of THF, methylene chloride, chloroform, C6H5CF3, and p-Clâ€”C6H4â€”CF3; and optionally at least one of methanol, ethanol, 1-propanol, 2-propanol, 1-hexanol, 2-methoxy ethanol, tetrahydrofuran, 1,4-dioxane, acetonitrile, dichloromethane, ammonia, chloroform, propylene carbonate, N,N-dimethylaceamide, dimethyl sulfoxide, formic acid, water, carbon disulfide, acetone, propane, toluene, hexanes, and pentanes; at a pressure between about 3,000 psi and 10,000 psi and at a temperature between about 50Â° C. and 100Â° C. to provide lupeol, betulin and betulinic acid.