Patent ID: 6689769
Filing Date: 2004-02-10
Classification: A61P,C07D

Abstract:
A compound having a structural formula: or a pharmaceutically acceptable salt or hydrate, or prodrug thereof,wherein Y1 is CH or N; Y2, Y3, and Y4, independently, are C or N; L is a bond or is a linker group attached to a carbon at the seven quinolone ring position or to an N at the one quinolone ring position, and selected from the group consisting of a bond, NR7, and NR8(CR92)nNR8; mis 0 or 1; n is 0-3; Q is selected from the group consisting of R1 is selected from the group consisting of null, H, C1-C4alkyl, C3-C5cycloalkyl, C1-C4haloalkyl, and halophenyl; R2 is null when Y2 is N, or is selected from the group consisting of H, alkyl, C1-C2alkoxy, halo, and haloalkoxy, when Y2 is C, or when Y2 is C, R1 and R2 can be taken together to form a 5- or 6-membered, optionally substituted, heteroalkyl or heteroaryl ring; R3 is H or F when Y3 is C, or R3 is null when Y3 is N; R4 is selected from the group consisting of H, methyl, amino, and F; R5 is selected from the group consisting of H, methyl, hydroxy, and halo; R6 is selected from the group consisting of H, methyl, hydroxy, and halo, when Y4 is C, or R6 is null when Y4 is N; R7 is selected from the group consisting of H, C1-C4 alkyl, formyl, alkylcarbonyl, alkylsulfonyl, and alkoxycarbonyl; R8, independently, are H or C1-C4alkyl, or are taken together to form a 4- to 9-membered, optionally substituted, heteroalkyl or heteroaryl ring; R9, independently, are H or C1-C4alkyl, or are taken together to form a 4- to 9-membered heterocyclic or heterobicyclic ring, optionally substituted with C1-C2alkyl, haloalkyl, or methoximino; R10 is selected from the group consisting of OH, alkoxy, aryloxy, and NHC(&boxH;Z)R11; R11 is selected from the group consisting of H, C1-C7alkyl, C3-C5cycloalkyl, hydroxymethyl, haloalkyl, CH2SMe, NR122, C1-C4alkoxy, and aryloxy; R12 is C1-C4alkyl; and Z is O or S.