Patent ID: 6169076
Filing Date: 2001-01-02
Classification: C07B,C07F,C07H

Abstract:
A method of making essentially salt-free carbohydrate and polyol (p-boronophenylalanine) complexes, comprising: a) providing: i) p-boronephenylalanine, ii) water, iii) a compound selected from the group consisting of carbohydrates and polyols, iv) a base, and v) an ion-exchange media; b) mixing said p-boronophenylalanine, said water, said compound, and said base, to produce a basic solution, such that said p-boronophenylalanine and said compound are substantially dissolved in said basic solution; c) adding said ion-exchange media to said basic solution, thereby adjusting the pH of said basic solution to the range of between about 7.3 and 7.5, to produce a mixture at physiological pH; and d) removing said ion-exchange media from said mixture to produce an essentially salt-free (p-boronophenylalanine) complex in solution.