Patent ID: 6551600
Filing Date: 2003-04-22
Classification: A61K,A61P,C07F

Abstract:
A compound of the formula 2: wherein:R1 is selected from the group consisting of (a) C(O); (b) C(O)-C1-14 alkyl-C(O), wherein said C1-14 alkyl is optionally substituted with hydroxy, C1-5 alkoxy, C1-5 alkylenedioxy, C105 alkylamino, or C1-5-alkyl-aryl, wherein said aryl moiety of said C1-5-alkyl-aryl is optionally substituted with C1-5 alkoxy, C1-5 alkyl amino, C1-5 alkoxy-amino, C1-5 alkylamino-C1-5 alkoxy, â€”Oâ€”C1-5 alkylamino-C1-5 alkoxy, â€”Oâ€”C1-5 alkylamino-C(O)-C1-5 alkyl C(O)OH, â€”Oâ€”C1-5 alkylamino-C(O)-C1-5 alkyl-C(O)-C1-5 alkyl; (c) C2 to C15 straight or branched chain alkyl optionally substituted with hydroxy or alkoxy; and (d) â€”C(O)-C6-12 arylene-C(O)- wherein said arylene is optionally substituted with hydroxy, halogen, nitro or amino; a and b are independently 0, 1, 2, 3 or 4 d, dâ€², dâ€³, e, eâ€² and eâ€³ are independently an integer from 1 or 4; X1, X2, Y1 and Y2 are independently selected from the group consisting of a null, oxygen, NH and N(C(O)C1-4 alkyl), and N(C1-4 alkyl)2; W1 and W2 are independently selected from the group consisting of carbonyl, methylene, sulfone and sulfoxide; R2 and R5 are independently selected from the group consisting of: (a) C2 to C20 straight chain or branched chain alkyl which is optionally substituted with oxo, hyroxy or alkoxy, (b) C2 to C20 straight chain or branched chain alkenyl or dialkenyul which is optionally substituted with oxo, hydroxy or alkoxy; (c) C2 to C20 straight chain or branched chain alkoxy which is optionally substituted with oxo, hydroxy or alkoxy; (d) â€”NH-C2 to C20 straight chain or branched chain alkyl, wherein said alkyl group is optionally substituted with oxo, hydroxy or alkoxy; and (e) wherein Z is selected from the group consisting of O and NH, and M and N are independently selected from the group consisting of C2 to C20 straight chain or branched chain alkyl, alkenyl, alkoxy, acyloxy, alkylamino, and acylamino;R3 and R6 are independently selected from the group consisting of C2 to C20 straight chain or branched chain alkyl or alkenyl optionally substituted with oxo or fluoro; R4 and R7 are independently selected from the group consisting of C(O)C2 to C20 straight chain or branched chain alkyl or alkenyl; C2 to C20 straight chain or branched chain alkyl; C2 to C20 straight chain or branched chain alkoxy; C2 to C20 straight chain or branched chain alkenyl; wherein said alkyl, alkenyl or alkoxy groups can be independently and optionally substituted with hydroxy, fluoro or C1 to C5 alkoxy; G1, G2, G3 and G4 are independently selected from the group consisting of oxygen, methylene, amino, thiol, â€”NHC(O)â€”, and â€”N(C(O)C1-4 alkyl)-; or G2R4 or G4R7 may together be a hydrogen atom or hydroxyl; aâ€² and bâ€² are independently 2, 3, 4, 5, 6, 7, and 8, preferably 2; Z1 is selected from the group consisting of â€”OP(O)(OH)2, â€”P(O)(OH)2, â€”OP(O)(OR8)(OH) where R8 is a C1-C4 alkyl chain, â€”OS(O)2OH, â€”S(O)2OH, â€”CO2H, â€”OB(OH)2, â€”OH, â€”CH3, â€”NH2, â€”NR93 where R9 is a C1-C4 alkyl chain; Z2 is selected from the group consisting of â€”OP(O)(OH)2, â€”P(O)(OH)2, â€”OP(O)(OR10)(OH) where R10 is a C1-C4 alkyl chain, -OS(O)2OH, â€”S(O)2OH, â€”CO2H, â€”OB(OH)2, â€”OH, â€”CH3, â€”NH2, â€”NR11, where R11 is a C1-C4 alkyl chain; or a pharmaceutically acceptable salt thereof.