Patent ID: 7368465
Filing Date: 2008-05-06
Classification: A61P,C07D

Abstract:
1. A compound of the formula I or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof wherein Y1 and Y2 are each O; Z is SO m is 1; A is a direct bond; R1 is H; one of R3 and R4 is H and the other of R3 and R4 and R6 join to form a ring of 5 atoms; R5 is a monocyclic ring structure of up to 7 ring atoms, which is selected from cycloalkyl, aryl, heterocycloalkyl and heteroaryl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, alkylsulfonamino, alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, haloalkylsulfonyl, alkylaminosulfonyl, carboxylate, alkylcarboxylate, aminocarboxy, N-alkylamino-carboxy, N,N-dialkylamino-carboxy, wherein any alkyl radical within any substituent may itself be optionally substituted with one or more groups selected from halogen, hydroxy, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, N-alkylsulfonamino, N-alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, N-alkylaminosulfonyl, carboxylate, alkylcarboxy, aminocarboxy, N-alkylaminocaboxy, N,N-dialkylaminocarboxy; or R5 is a bicyclic ring structure, wherein each ring in the bicyclic ring structure is, independently, a ring of up to 7 ring atoms, wherein each ring in the bicyclic ring structure is, independently, selected from cycloalkyl, aryl, heterocycloalkyl and heteroaryl, and wherein each ring in the bicyclic ring structure is, independently, optionally substituted by one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, alkylsulfonamino, alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, haloalkylsulfonyl, alkylaminosulfonyl, carboxylate, alkylcarboxylate, aminocarboxy, N-alkylamino-carboxy, N,N-dialkylamino-carboxy, wherein any alkyl radical within any substituent may itself be optionally substituted with one or more groups selected from halogen, hydroxy, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, N-alkylsulfonamino, N-alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, N-alkylaminosulfonyl, carboxylate, alkylcarboxy, aminocarboxy, N-alkylaminocaboxy, N,N-dialkylaminocarboxy; or R5 is a tricyclic ring structure, wherein each ring in the tricyclic ring structure is, independently, a ring of up to 7 ring atoms, wherein each ring in the tricyclic ring structure is, independently, selected from cycloalkyl, aryl, heterocycloalkyl and heteroaryl, and wherein each ring in the tricyclic ring structure is, independently, optionally substituted by one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, alkylsulfonamino, alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, haloalkylsulfonyl, alkylaminosulfonyl, carboxylate, alkylcarboxylate, aminocarboxy, N-alkylamino-carboxy, N,N-dialkylamino-carboxy, wherein any alkyl radical within any substituent may itself be optionally substituted with one or more groups selected from halogen, hydroxy, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, N-alkylsulfonamino, N-alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, N-alkylaminosulfonyl, carboxylate, alkylcarboxy, aminocarboxy, N-alkylaminocaboxy, N,N-dialkylaminocarboxy; when R5 is a bicyclic ring structure or tricyclic ring structure, each ring in the bicyclic or tricyclic ring structure is joined to the next ring in the bicyclic or tricyclic ring structure by a direct bond, by —O—, by (C1-6)alkyl, by (C1-6)haloalkyl, by (C1-6)heteroalkyl, by (C1-6)alkenyl, by (C1-6)alkynyl, by sulfone, or is fused to the next ring structure; Provided that: