Patent ID: 9090941
Filing Date: 2015-07-28
Classification: C12Q

Abstract:
1. A method comprising: providing a colorectal cancer sample from a human subject; determining in the provided sample from the subject a first methylation level of lecithin:retinol acyl transferase gene promoter having a nucleotide sequence corresponding to the nucleotide sequence of SEQ ID NO: 1; providing a second methylation level of the lecithin:retinol acyl transferase gene promoter having a nucleotide sequence corresponding to the nucleotide sequence of SEQ ID NO: 1, said second methylation level being from either (1) a colorectal sample obtained from the subject at a time before said determining, or (2) one or more reference samples obtained from early stage colorectal tumors or benign colorectal tissue; comparing the first methylation level of the lecithin:retinol acyl transferase gene promoter nucleotide sequence with the second methylation level of the lecithin:retinol acyl transferase gene promoter nucleotide sequence detecting a decrease in the first methylation level compared to the second methylation level; and administering a pharmaceutical composition comprising a lecithin:retinol acyl transferase inhibitor to the subject based on said detecting.