Patent ID: 6221899
Filing Date: 2001-04-24
Classification: A61K,Y02A

Abstract:
A method for the treatment of IL-1 and TNF mediated diseases of a subject in need of such treatment which comprises administering to said subject an anti-inflammatory amount of a compound of the formula ##STR6##wherein the dotted line is an optional bond;R.sup.1 is O or OH;X is O ot N, or absent;R.sup.2 is H, OH, C.sub.1 -C.sub.5 alkyl or benzyl, or absent;R.sup.3 is H, OH, C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.3 alkenyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio;R.sup.4 is H or C.sub.1 -C.sub.5 alkoxy;R.sup.5 is H, C.sub.1 -C.sub.4 alkylthio or C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.4 alkoxycarbonyl-C.sub.1 -C.sub.4 alkylthio, or absent;R.sup.6 is H or OH; orR.sup.5 and R.sup.6 form, together with the carbon atom to which they are attached, an oxirane ring;R.sup.7 is H;R.sup.8 is OH; orR.sup.7 and R.sup.8 form, together with the carbon to which they are attached, a lactone ring; with proviso that when X and O and R.sup.2 is absent, the dotted line between 3- and 4-position is a single bond;and a pharmaceutically acceptable carrier.