Patent ID: 8753815
Filing Date: 2014-06-17
Classification: A61K,A61P,C12Q,G16B

Abstract:
1. A method of treating an alcohol-related disease or disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of ondansetron, wherein the disease or disorder is alcohol abuse or alcohol dependence and the patient's HTR3A gene and optionally serotonin transporter gene SLC6A4 and/or HTR3B gene is known to have a genotype selected from: i. the AG genotype of rs1150226; ii. the AG genotype of rs1150226 and the AC genotype of rs17614942; iii. the AG genotype of rs1150226, the LL genotype of 5-HTTLPR, and the TT genotype of rs1042173; and iv. the AG genotype of rs1150226, the AC genotype of rs17614942, the LL genotype of 5-HTTLPR, and the TT genotype of rs 1042173.