Patent ID: 6949539
Filing Date: 2005-09-27
Classification: A61P,C07D

Abstract:
1. A compound of formula wherein m represents 1, 2 or 3; each R 1 independently represents a hydrogen or halogen atom; A represents C(O)NH or NHC(O); Ar represents a group X represents a bond, an oxygen atom or a group (CH 2 ) 1-6 , CH═, (CH 2 ) 1-6 O, O(CH 2 ) 1-6 , O(CH 2 ) 2-6 O, O(CH 2 ) 2-3 O(CH 2 ) 1-3 , (CH 2 ) 1-3 O(CH 2 ) 1-3 (CH 2 ) 1-3 O(CH 2 ) 2-3 O, NR 5 , (CH 2 ) 1-6 NR 5 , NR 5 (CH 2 ) 1-6 , (CH 2 ) 1-3 NR 5 (CH 2 ) 1-3 , O(CH 2 ) 2-6 NR 5 , O(CH 2 ) 2-3 NR 5 (CH 2 ) 1-3 , (CH 2 ) 1-3 NR 5 (CH 2 ) 2-3 O, NR 5 (CH 2 ) 2-6 O, NR 5 (CH 2 ) 2-3 O(CH 2 ) 1-3 ; one of R 2 and R 3 represents a halogen, cyano, nitro, amino, hydroxyl, or a group selected from (i) C 1 -C 6 alkyl optionally substituted by at least one C 3 -C 6 cycloalkyl, (ii) C 3 -C 8 cycloalkyl, (iii) C 1 -C 6 alkyloxy optionally substituted by at least one C 3 -C 6 cycloalkyl, and (iv) C 3 -C 8 cycloalkyloxy, each of these groups being optionally substituted by one or more fluorine atoms, and the other of R 2 and R 3 represents a hydrogen or halogen atom; either R 4 represents a 3- to 9-membered saturated or unsaturated aliphatic heterocyclic ring system containing one or two nitrogen atoms and optionally an oxygen atom, the heterocyclic ring system being optionally substituted by one or more substituents independently selected from fluorine atoms, hydroxyl, carboxyl, cyano, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, —NR 6 R 7 , —(CH 2 ) r NR 6 R 7 and —CONR 6 R 7 , or R 4 represents a 3- to 8-membered saturated carbocyclic ring system substituted by one or more substituents independently selected from —NR 6 R 7 , —(CH 2 ) r NR 6 R 7 and —CONR 6 R 7 , the ring system being optionally further substituted by one or more substituents independently selected from fluorine atoms, hydroxyl and C 1 -C 6 alkyl; r is 1, 2, 3, 4, 5 or 6; R 5 represents a hydrogen atom or a C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl group; R 6 and R 7 each independently represent a hydrogen atom or a C 1 -C 6 alkyl, C 2 -C 6 hydroxyalkyl or C 3 -C 8 cycloalkyl group, or R 6 and R 7 together with the nitrogen atom to which they are attached form a 3- to 8-membered saturated heterocyclic ring; with the provisos that, (a) when A represents C(O)NH and R 4 represents an unsubstituted 3- to 8-membered saturated aliphatic heterocyclic ring system containing one nitrogen atom, then X is other than a bond, and (b) when A represents C(O)NH and X represents a group (CH 2 ) 1-6 or O(CH 2 ) 1-6 , then R 4 does not represent an unsubstituted imidazolyl, unsubstituted morpholinyl, unsubstituted piperidinyl or unsubstituted pyrrolidinyl group, and (c) when A represents NHC(O) and R 4 represents an unsubstituted 3- to 8-membered saturated aliphatic heterocyclic ring system containing one nitrogen atom, then X is other than a bond, and (d) when A represents NHC(O) and X represents O(CH 2 ) 1-6 or NH(CH 2 ) 1-6 , then R 4 does not represent an unsubstituted 1-piperidinyl or unsubstituted 1-pyrrolidinyl group, and (e) when A represents NHC(O) and X represents O(CH 2 ) 2-3 NH(CH 2 ) 2 , then R 4 does not represent an imidazolyl group; or a pharmaceutically acceptable salt or solvate thereof.