Patent ID: 6696571
Filing Date: 2004-02-24
Classification: C07B,C07C,C07D

Abstract:
A process for producing 5-halomethyl-5-hydroxy-3-oxazolidine derivatives of following general formula (2): wherein R represents an unsubstituted or substituted aryl group or lower alkyl group or hydrogen atom, A represents an unsubstituted or substituted alkyl group having 1 to 10 carbon atoms, aryl group having 6 to 15 carbon atoms or aralkyl group having 7 to 20 carbon atoms, or a unsubstituted or substituted alkyl group having 1 to 10 carbon atoms containing a hetero atom in the carbon skeleton, aryl group having 6 to 15 carbon atoms containing a hetero atom in the carbon skeleton or aralkyl group having 7 to 20 carbon atoms containing a hetero atom in the carbon skeleton; B1 represents a protecting group for the amino group, and X represents a halogen atom, which comprises the step of reacting a 3-oxazolidin-5-one derivative of following general formula (1): wherein R, A and B1 are as defined above with a halomethyllithium.