Patent ID: 9089485
Filing Date: 2015-07-28
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition in the form of a tablet dosage form, said composition comprising 20-45% w/w of entacapone or salts thereof, 5-40% w/w of levodopa or salts thereof and 1-10% w/w of carbidopa or salts thereof; said composition obtained by: (a) co-micronizing entacapone or salts thereof with one or more sugar alcohols in presence of one or more pharmaceutically acceptable excipients, such that the co-micronized entacapone or salts thereof and sugar alcohol mixture has a mean particle size of less than 30μ; (b) mixing and granulating carbidopa or salts thereof, and levodopa or salts thereof with one or more pharmaceutically acceptable excipients; (c) mixing the mixture obtained in step (a) and (b); and (d) compressing the mixture obtained in step (c) into a tablet dosages form.