Patent ID: 9096672
Filing Date: 2015-08-04
Classification: A61K,A61P,B82Y,C07K,Y10S

Abstract:
1. An isolated human monoclonal antibody that binds to EGFRvIII comprising: a heavy chain polypeptide comprising the following complementarity determining regions (CDRs): a heavy chain CDR1 that is a CDR1 in SEQ ID NO: 142; a heavy chain CDR2 that is a CDR2 in SEQ ID NO: 142; a heavy chain CDR3 that is a CDR3 in SEQ ID NO: 142; a light chain polypeptide comprising the following CDRs: a light chain CDR1 that is a CDR1 in SEQ ID NO: 144; a light chain CDR2 that a CDR2 in SEQ ID NO: 144; and a light chain CDR3 that is a CDR3 in SEQ ID NO: 144; and a Maytansinoid toxin conjugated to the antibody.