Patent ID: 8252326
Filing Date: 2012-08-28
Classification: A61K

Abstract:
1. A soft capsule containing an active ingredient comprising the active ingredient contained in a stable self-microemulsifying mixture, said mixture comprising: (1) at least one hydrophilic surfactant having a hydrophile-lipophile balance of greater than 12; (2) at least one lipophilic co-surfactant having a hydrophile-lipophile balance of less than 8; and (3) at least one hydrophobic solvent; wherein the weight ratio of said at least one hydrophilic surfactant to said at least one lipophilic co-surfactant is in the range of from 30:1 to 3:1; wherein the concentration of said at least one hydrophobic solvent in said self-microemulsifying mixture is in the range of from 2 to 50% by weight and comprises a mixture of isopropyl myristate and lemon oil or a mixture of isopropyl myristate and orange oil; and wherein the self-microemulsifying mixture exhibits a dissolution of up to 100% and storage stability of more than 80 days.