Patent ID: 6245786
Filing Date: 2001-06-12
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula ##STR12##whereinR.sub.1 is independently H or alkyl of 1 to 6 carbons;m is an integer having the value of 0-5;p is an integer having the value of 0-2;r is an integer having the value 0-2;with the proviso that the sum of p and r is at least 1;Z is O or S;W is a substituent selected independently from the group consisting of F, Br, Cl, I, C.sub.1-6 alkyl, fluoro substituted C.sub.1-6 alkyl, NO.sub.2, N.sub.3, OH, OCH.sub.2 OCH.sub.3, OC.sub.1-10 alkyl, tetrazol, CN, SO.sub.2 C.sub.1-6 -alkyl, SO.sub.2 C.sub.1-6 -fluoro substituted alkyl, SO--C.sub.1-6 alkyl, CO--C.sub.1-6 alkyl, COOR.sub.8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl;R.sub.8 is H, an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons or a pharmaceutically acceptable salt of said compound.