Patent ID: 7790171
Filing Date: 2010-09-07
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An inhibitor of HIV replication, comprising an antiviral peptide, wherein: the antiviral peptide consists of a decapeptide containing (from the N-terminus to the C-terminus) a basic amino acid at position 1; an acidic amino acid at positions 2 and 5; a tryptophan at positions 4, 7, and 8; a threonine, isoleucine or valine at position 3; a threonine, alanine, or glutamine at position 6; a threonine, alanine, valine, isoleucine, methionine, or aspartate at position 9; and a glutamate, aspartate or asparagine at position 10; the decapeptide inhibits the dimerization of HIV reverse transcriptase; and the decapeptide is not KETWETWWTE (SEQ ID NO: 1).