Patent ID: 6022379
Filing Date: 2000-02-08
Classification: A61K,A61Q,C07D

Abstract:
A compound of formula (I) or (II): ##STR29## wherein, in said formulae (I) or (II): R.sub.1 and R.sub.2 are independently selected from a hydrogen atom, an OH radical, C.sub.1 -C.sub.4 alkyl radicals, C.sub.1 -C.sub.4 alkoxy radicals and a radical Z of formula (III): ##STR30## R.sub.3 to R.sub.6 independently are selected from a hydrogen atom, halogen atoms, an OH radical, C.sub.1 -C.sub.4 alkyl radicals and C.sub.1 -C.sub.4 alkoxy radicals,D is a covalent bond between the pyrrole ring (III) and the ring of structure (I) or (II),R.sub.7 to R.sub.11 independently are chosen from a hydrogen, optionally substituted C.sub.1 -C.sub.18 alkyl radicals, SO.sub.2 --C.sub.6 H.sub.5, CO(C.sub.1 -C.sub.4)alkyl radicals, a CH.sub.2 C.sub.6 H.sub.5 radical, COOH and salts thereof, COO(C.sub.1 -C.sub.4)alkyl radicals, CONR'R"" wherein R' and R"" independently are chosen from H, and C.sub.1 -C.sub.4 alkyl radicals, and C.sub.6 H.sub.5 radicals which may be substituted with one or more halogen atoms or one or more hydroxyl groups, C.sub.1 -C.sub.4 alkyl radicals, or C.sub.1 -C.sub.4 alkoxy radicals, and R.sub.8 to R.sub.11 may also denote at least one bond D, wherein(i) at least one of the radicals R.sub.1 and R.sub.2 denotes a radical Z, and(ii) the attachment of Z to the rings of formulae (I) or (II) is carried out on any of the positions 2 to 5 of the pyrrole ring of formula (III),and wherein the following compounds are excluded:2-(1-benzenesulphonyl-1H-pyrrol-2-yl)-[1,4]-naphthoquinone,2-(1-benzyl-1H-pyrrol-2-yl)-3-methoxy-[1,4]-naphthoquinone,2-(1-ethyl-1H-pyrrol-2-yl)-3-methoxy-[1,4]-naphthoquinone,2-(1H-pyrrol-2-yl)-3-methoxy-[1,4]-naphthoquinone,2-(1-methyl-1H-pyrrol-2-yl)-3-methyl-[1,4]-naphthoquinone,2-(1-methyl-1H-pyrrol-2-yl)-3-methoxy-[1,4]-naphthoquinone,1-methyl-2,5-bis-([1,4]-dihydroxynaphthalene)-pyrrole,2-(2,5-diethyl-1-methyl-pyrrol-3-yl)-[1,4]-naphthoquinone,2-(1-methyl-1H-pyrrol-2-yl)-[1,4]-dihydroxynaphthalene, andcompounds of formula (IV): ##STR31## in which: R.sub.12 is chosen from H, alkyl, aryl and aralkyl groups andR.sub.13, R.sub.14 and R.sub.15 independently are chosen from H, alkyl, aryl, and SO.sub.2 --C.sub.6 H.sub.5.