Patent ID: 6423296
Filing Date: 2002-07-23
Classification: A61K,B82Y

Abstract:
A process for producing composite magnetic particles, said process comprising:(a) forming iron oxide particles within a polysaccharide containing aqueous medium; and (b) cleaving said polysaccharide whereby to release said composite particles, said process comprising the following sequential steps: (i) combining in a heated aqueous solution a polysaccharide, ferrous and ferric salts, and a base; (ii) optionally, cooling said solution to below 15Â° C. to allow said medium to set; (iii) reducing the pH to within the range 6.0 to 8.5, this step optionally being performed before step (ii); (iv) treating with an oxidant to cleave the polysaccharide and release said particles; (v) washing and filtering the released particles; (vi) optionally, reacting the released particles with a functionalized polyalkyleneoxide to bind said functionalized polyalkyleneoxide to said particles; and (vii) optionally, autoclave sterilizing the released particles.