Patent ID: 6706878
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A compound of formula I wherein n is 0 or 1;m is 0 or 1; p is 0; Y is CH, N or NO X is oxygen or sulfur; W is two H moieties; A is N or C(R2); G is N or C(R3); D is N or C(R4); with the proviso that no more than one of A, G, and D is nitrogen but at least one of Y, A, G, and D is nitrogen or NO;R1 is hydrogen or C1-C4 alkyl; R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R1, â€”CN, â€”NO2, â€”NR5R6, â€”CF3, â€”OSO2CF3, or R2 and R3, or R3 and R4, respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents: independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R1, â€”CN, â€”NO2, â€”NR5R6, â€”CF3, OSO2CF3; R5 and R6 are independently hydrogen, C1-C4 alkyl, C(O)R7, C(O)NHR8, C(O)OR9, SO2R10 or may together be (CH2)jQ(CH2)k where Q is O, S, NR11, or a bond; j is 2 to 7; k is 0 to 2; R7, R8, R9, R10, and R11 are independently C1-C4 alkyl, aryl, or heteroaryl; made by the process of deprotecting a compound of formula IIA by removing the borane complex from said compound of formula IIA by treating with acid in a solvent or heating in an alcoholic solvent.