Patent ID: 8357664
Filing Date: 2013-01-22
Classification: C12N

Abstract:
1. A method of treating influenza virus A infection in a mammalian subject, comprising: administering by inhalation to the mammalian subject, a therapeutically effective amount of an antisense conjugate comprising a substantially uncharged antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages which join a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, and having a targeting sequence of at least 12 contiguous bases that are complementary to SEQ ID NO: 3, and an arginine-rich carrier peptide having the sequence identified by SEQ ID NO: 26 covalently attached to the oligonucleotide, wherein said therapeutically effective amount is an amount effective to reduce viral titer in said subject by at least tenfold compared to an untreated or nonsense-treated control.