Patent ID: 6255323
Filing Date: 2001-07-03
Classification: C07D

Abstract:
A compound of the following formula: ##STR6##whereinR.sup.1 is 3-pyridyl, 4-pyridyl, or quinolinyl, optionally substituted with alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkoxy, hydroxyl, hydroxylalkyl, carboxyl, halo, haloalkyl, amino, aminoalkyl, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylcarbonylamino, aminocarbonyl, alkylsulfonylamino, aminosulfonyl, sulfonic acid, or alkylsulfonyl;each of R.sup.2 and R.sup.3, independently, is hydrogen, alkyl, alkoxy, hydroxylalkyl, thioalkyl, aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylcarbonylamino, or aminocarbonyl;L.sup.1 is --X.sup.1 --Y.sup.1 --X.sup.2 -- in which each of X.sub.1 and X.sup.2, independently, is a bond, or a C.sub.1-6 alkylene chain optionally containing a double bond or a triple bond and further optionally substituted with alkoxy, hydroxyl, halo, carboxyl, amino, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aminosulfonyl, alkylsulfonylamino, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, formyl, alkylcarbonylamino, or aminocarbonyl; and Y.sup.1 is --O--, --S--, --SO--, --SO.sub.2 --, --N(R.sup.a)--, --CO--, --N(R.sup.a)--CO--, --CO--N(R.sup.a)--, --N(R.sup.a)--CO--CO--, --N(R.sup.a)--SO.sub.2 --, --SO.sub.2 --N(R.sup.a)--, --N(R.sup.a)--CO--O--, --O--CO--N(R.sup.a)--, --N(R.sup.a)--CO--N(R.sup.b)--, --N(R.sup.a)--CS--N(R.sup.b)--CO--, --CO--N(R.sup.a)--CS--N(R.sup.b)--, --O--CO--, --CO--O--, --O--SO.sub.2 --, --SO.sub.2 --O--, --O--S--CO--N(R.sup.a)--, --N(R.sup.a)--CO--S--O--, --O--CO--O--, --CO--N(R.sup.a)--S--CO--N(R.sup.b)--, --N(R.sup.a)--CO--S--N(R.sup.b)--CO--, or a bond; each of R.sup.a and R.sup.b, independently, being hydrogen, alkyl, alkoxy, hydroxylalkyl, hydroxyl, amino, nitro, cyano, halo, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl;R.sup.4 is aryl, optionally substituted with alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkoxy, hydroxyl, hydroxylalkyl, carboxyl, halo, haloalkyl, amino, aminioalkyl, nitro, cyano, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, formyl, oxo, alkylcarbonylamino, aminocarbonyl, alkylsulfonylamino, aminosulfonyl, sulfonic acid, or alkylsulfonyl;L.sup.2 is --X.sup.3 --Y.sup.2 --X.sup.4 -- in which each of X.sup.3 and X.sup.4, independently, is a bond, or a C.sub.1-6 alkylene chain optionally containing a double bond or a triple bond and further optionally substituted with alkoxy, hydroxyl, halo, carboxyl, amino, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aminosulfonyl, alkylsulfonylamino, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, formyl, alkylcarbonylamino, or aminocarbonyl; and Y.sup.2 is --O--, --S--, --SO--, --SO.sub.2 --, --N(R.sup.c), --CO--, --N(R.sup.c)--CO--, --CO--N(R.sup.c)--, --N(R.sup.c)--CO--CO--, --N(R.sup.c)--SO.sub.2 --, --SO.sub.2 --N(R.sup.c)--, --N(R.sup.c)--CO--O--, --O--CO--N(R.sup.c)--, --N(R.sup.c)--CO--N(R.sup.d)--, --N(R.sup.c)--CS--N(R.sup.d)--CO--, --CO--N(R.sup.c)--CS--N(R.sup.d)--, --O--CO--, --CO--O--, --O--, SO.sub.2 --, --SO.sub.2 --O--, --O--S--CO--N(R.sup.c)--, --N(R.sup.c)--CO--S--O--, --O--CO--O--, --CO--N(R.sup.c)--S--CO--N(R.sup.d)--, --N(R.sup.c)--CO--S--N(R.sup.d)--CO-- or a bond; each of R.sup.c and R.sup.d, independently, being hydrogen, alkyl, alkoxy, hydroxylalkyl, hydroxyl, amino, nitro, cyano, halo, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; andR.sup.5 is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, or heteroaryl, optionally substituted with alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, alkoxy, hydroxyl, hydroxylalkyl, carboxyl, halo, haloalkyl, amino, aminoalkyl, nitro, cyano, aryloxy, heteroaryloxy, aralkoxy, heteroaralkoxy, alkylcarbonyloxy, alkyloxycarbonyl, arylcarbonyloxyalkyl, aryloxycarbonylalkyl, alkylcarbonyl, formyl, oxo, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, aminosulfonyl, aminocarbonyloxy, or alkyloxycarbonylamino;provided that each of Y.sup.1 and Y.sup.2 is not a bond simultaneously; and that when neither Y.sup.1 nor Y.sup.2 is a bond, at least one of X.sup.2, R.sup.4, and X.sup.3 is not a bond;or an N-oxide derivative or a salt thereof.