Patent ID: 6943163
Filing Date: 2005-09-13
Classification: A61P,C07D,C07F

Abstract:
1. A method of treating hypertension, neuronal hypertonia, stable and unstable angina, peripheral and cardial vasculopathies, arrhythmiae, thromboembolic disorders, myocardial infarction, angina pectoris, peripheral circulation obstruction, restenoses after thrombolysis therapy, percutaneous transluminal coronary angioplasties or bypass, stroke, hypertrophy of the prostate and incontinence, comprising administering to a mammal an effective amount of a compound of the formula (I) in which R R R  in which and where aryl and the heterocycle are optionally mono- to trisubstituted by identical or different substituents from the group consisting of nitro, halogen, —SO R R  or represent cycloalkyl having 3 to 8 carbon atoms, aryl having 6 to 10 carbon atoms or represent a 5- to 7-membered partially unsaturated, saturated and unsaturated, optionally benzo-fused heterocycle which may contain up to 4 heteroatoms from the group consisting of S, N; O or a radical of the formula —NR  or  represents cycloalkyl having 3 to 7 carbon atoms, or hydrogen or straight-chain or branched alkyl having up to 5 carbon atoms which is optionally substituted by cycloalkyl having 3 to 7 carbon atoms, straight-chain or branched alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms, hydroxyl, carboxyl or phenyl, which for its part may be mono- to trisubstituted by identical or different substituents from the group consisting of straight-chain or branched alkoxy having up to 4 carbon atoms, hydroxyl and halogen, and/or cycloalkyl, aryl and/or the heterocycle are optionally substituted by straight-chain or branched alkyl having up to 6 carbon atoms which is optionally substituted by hydroxyl, carboxyl, by a 5- to 7-membered heterocycle having up to 3 heteroatoms from the group consisting of S, N and/or O or by groups of the formulae —SO R and the heterocycle mentioned under R and/or the heterocycle mentioned under R and/or the alkyl is optionally substituted by benzyloxy or aryl having 6 to 10 carbon atoms which for its part way be mono- to trisubstituted by identical or different substituents from the group consisting of halogen, hydroxyl, straight-chain or branched alkoxy or alkylthio having in cash case up to 6 carbon atoms, or by a group of the formula —NR and/or the heterocycle mentioned under R R  in which R or stereoisomers thereof.