Patent ID: 7442496
Filing Date: 2008-10-28
Classification: C12Q,G01N

Abstract:
1. A method for diagnosing the clinical state of schizophrenia in a subject, said method comprising the steps of: obtaining a sample, wherein said sample is isolated mitochondria from either a mammalian blood, or a muscle tissue from the subject; determining the level of activity of the mitochondrial complex I enzyme in said sample; and comparing said level of activity wish a normative value of activity of mitochondrial complex I enzyme; wherein an increase in mitochondrial complex I enzyme activity in said sample compared with said normative value is indicative of the subject having schizophrenia at an acute phase or a residual phase with pronounced positive symptoms and a decrease in mitochondrial complex I enzyme activity in said sample compared with said normative value is indicative of the subject having schizophrenia at a residual phase with pronounced negative symptoms.