Patent ID: 6025471
Filing Date: 2000-02-15
Classification: A61K,C07K

Abstract:
A peptide of the formula:A-B-D-Mrp-C-Ein which:B is a spirolactam substituent of the formula ##STR7## where A is H or Tyr, R.sup.2 represents the side chain of any one naturally occurring amino acid, and the configuration at * is (R), (S) or a mixture thereof; a tricyclic substituent of the formula: ##STR8## where A is H or Tyr and the configuration at * is (S), (R) or a mixture thereof; a bicyclic substituent of the formula: ##STR9## where A is H or Tyr and the configuration at * is (R), (S) or a mixture thereof; D-Mrp is Dextro-2-Alkyl-Trp, where the Alkyl group contains 1 to 3 carbon atoms;C is Trp-Phe, D-Trp-Phe, Mrp-Phe, D-Mrp-Phe, Trp, D-Trp, Mrp, D-Mrp, Ala-Trp-D-Phe, Ala-Mrp-D-Phe, Ala-D-Mrp-D-Phe, D-Lys-Trp-D-Phe, D-Lys-Mrp-D-Phe, D-Lys-D-Mrp-D-Phe, or a tricyclic substituent of the formula: ##STR10## where R.sup.5 is H or SO.sub.2 Me and the configurations at * are either (R), (S), or a mixture thereof; andE is Lys-NH.sub.2 or -NH.sub.2.