Patent ID: 6504024
Filing Date: 2003-01-07
Classification: C07H,C12Q

Abstract:
A propargylethoxyamino nucleotide having the structure: wherein:n is 1 or 2; R1 and R2 are independently selected from H, C1-C8 lower alkyl, and a protecting group, or R1 and R2 taken together is a protecting group; B is a 7-deazapurine, a purine, or a pyrimidine nucleoside base; when B is purine or 7-deazapurine, the sugar moiety is attached at the N9-position of the purine or 7-deazapurine, and when B is pyrimidine, the sugar moiety is attached at the N1-position of the pyrimidine; and when B is a purine, the adjacent triple-bonded carbon is attached to the 8-position of the purine, when B is 7-deazapurine, the adjacent triple-bonded carbon is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, the adjacent triple-bonded carbon is attached to the 5-position of the pyrimidine; W1 is H or OH; W2 is selected from H, OH, and a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3â€²-position; and W3 is selected from OH, phosphate, diphosphate, triphosphate, an activated phosphate, and a phosphate analog.