Patent ID: 8945551
Filing Date: 2015-02-03
Classification: A61K

Abstract:
1. A prolonged release and/or controlled release delivery system for delivery of a biologically active agent, the system comprising: (i) a first component comprising a biocompatible polyaminosaccharide; and (ii) a second component comprising a biocompatible phosphate or biocompatible sulphonamide compound capable of crosslinking with the first component, wherein the delivery system further comprises the biologically active agent, an aqueous insoluble alkaline earth metal phosphate, and a biocompatible glycan; wherein each of the biologically active agent, aqueous insoluble earth metal phosphate and biocompatible glycan is present in either of the first and/or second components; and wherein the % wt/wt ratio ranges of: the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1; and the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184; and whereby the first and second components of the system are physically isolated and, when in use, combining of the first and second components promotes crosslinking and results in the formation of a biopolymer hybrid gel-depot including the biological active agent.