Patent ID: 7297708
Filing Date: 2007-11-20
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): or a pharmaceutically acceptable salt form thereof, wherein: W is NR X is C; Y is CR Z is C; R R R R each R each R 10 is, independently, H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, aryl, heteroaryl or heterocyclyl, —CN, —CH 2 CN, —CH 2 OR 23 , CH 2 NR 23 R 24 , —CH 2 OH, —NO 2 , C 3 -C 6 cycloalkyl, —NR 23 R 24 , —NR 23 COR 24 , —NHSO 2 R, —COR 23 , —CO 2 R 23 , —OR 23 , —OC 2 H 4 OR 23 , —SR 23 , —S(O) n R 23 , —S(O) n NR 23 R 24 , —CH(OH)R 23 , —CH 2 COR 23 , —OC(O)R 23 , —OCHR 23 CO 2 R 24 , —OCHR 23 COR 24 , —NR 23 CONR 23 R 24 , —NR 23 CO 2 R 24 , —CONR 23 R 24 , or —CH(OH)C(R 23 ) 3 , wherein each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN; each R each R each R each R each R each R Ar is phenyl, benzyl, or naphthyl, wherein said Ar is optionally substituted with 1 to 5 R n is 0-2; aryl is phenyl, benzyl or naphthyl, each optionally substituted with 1 to 10 substituents independently selected at each occurrence from H, halogen, C heteroaryl is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl , pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 10 substituents independently selected at each occurrence from H, halogen, C heterocyclyl is optionally substituted with 1 to 10 substituents independently selected at each occurrence from H, halogen, C