Patent ID: 6784173
Filing Date: 2004-08-31
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I â€ƒis a thiophene ring that may be unsubstituted or substituted by 1 or 2 substituents independently selected from a halogen atom, a C1-4-alkyl-, trifluoromethyl-, hydroxy-, C1-4-alkoxy-, nitro-, amino-, C1-4-alkylamino-, di[C1-4-alkyl]-amino-, C1-4-alkanoylamino, C1-3-alkylenedioxy- or an acyl group; and R1 and R2 are each independently selected from hydrogen, a branched or unbranched C1-4-alkyl group that may be unsubstituted or substituted with 1 or more substituents independently selected from halogen, hydroxy-, nitro-, an amino group, a carbocyclic group or a heterocyclic group, and wherein at a chain length of longer than 2 carbon atoms, one or more non adjacent atoms may be replaced by oxygen, nitrogen or sulfur atoms, and wherein 2 atoms may be bound together by a double or triple bond, a carbocyclic group, and a heterocyclic group, or alternatively, the group â€”NR1R2 forms a 3-6 membered ring that may contain additional heteroatoms independently selected from nitrogen, oxygen and sulfur, said ring optionally being annulated to a carbocyclic ring or a heterocyclic ring, and said â€”NR1R2 ring being unsubstituted or optionally substituted by 1, 2, or 3 substituents independently selected from a halogen atom, an C1-4-alkyl-, trifluoromethyl-, hydroxy-, C1-4-alkoxy-, aryl-, hetaryl-, arylalkyl, arylalkyloxy-, aryloxy, C1-3-alkylenedioxy-, nitro-, amino-, C1-4-alkylamino-, di[C1-4-alkyl]amino-, C1-4-alkanoylamino- or an acyl-group; and their enantiomers, diastereoisomers, racemates and physiologically acceptable salts thereof.