Patent ID: 6703390
Filing Date: 2004-03-09
Classification: A61P,C07D

Abstract:
A compound of Formula I: whereinR1, R2, R3 and R4 are independently H, HO, R11Oâ€”, halogen, C1-C3-alkyl, CF3, R12CO2â€”, R12O2Câ€”, R12COâ€”, R12CONHâ€”, R12NHCOâ€”, R12NHCO2â€”, R12OCONHâ€”, R12O2Sâ€”, R12OSâ€”, or R13R14Nâ€”; or R1 and R2, or R2 and R3, or R3 and R4 taken together are â€”SCH2Sâ€”, â€”SCH2Oâ€”, â€”OCH2Sâ€”, â€”SCH2CH2Sâ€”, â€”SCH2CH2Oâ€”, or â€”OCH2CH2Sâ€”; wherein at least one of R1, R2, R3 and R4 must be a C1-C3-alkylthio group, R5 and R6 independently H, C1-C6-alkyl, C3-C6-alkenyl, C3-C6-cycloalkyl, or phenyl or substituted phenyl, wherein the phenyl is substituted with one or two substituents selected from the group consisting of C1-C3-alkyl, halogen, R11Oâ€”, CF3â€”, R12O2Sâ€”, R12OSâ€”, R12CO, R12CO2â€”, R12O2Câ€”, R12CONHâ€”, R12NHCOâ€”, R12NHCO2â€”, R12OCONH, and R13R14Nâ€”; or R5 and R6 taken together are C3-C6-cycloalkyl; R7 is R13R14NCOâ€”, R13R14NCSâ€”, R15OCOâ€”, R13COâ€”, R13R14NCH2COâ€”, R12O2Câ€”(CH2)nâ€”, R13R14NCOâ€”(CH2)nâ€”, NCâ€”(CH2)nâ€”, H, C1-C6-alkyl, C3-C6-alkenyl, or C3-C6-cycloalkyl; or R6 and R7 taken together are â€”(CH2)mCH2(R13)NCOâ€”, â€”(CH2)mCH2OCOâ€”, or â€”(CH2)mCH2CH2COâ€”; R8 and R9 are independently H, R13R14Nâ€”, R12HNCOâ€”, or R12CONHâ€”; R10 is H, halogen, HO, R11Oâ€”, R13R14Nâ€”, C1-C3-alkyl, CF3, R12CO2â€”, R12COâ€”, or R12CONHâ€”; R11 is C1-C3-alkyl; R12 is H or C1-C3-alkyl; R13R14 are independently H, C1-C10-alkyl, C1-C6-perfluoroalkyl, C3-C10-alkenyl, or C3-C6-cycloalkyl; or R13 and R14 taken together are C3-C6-cycloalkyl; R15 is C1-C6-alkyl, C3-C6-alkenyl, or C3-C6-cycloalkyl; n is 1 to 6; m is 0 to 2; or pharmaceutically acceptable salts thereof;wherein R8 and R9 cannot be both be H.