Patent ID: 6159974
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A method for promoting expression of LDL receptor gene, which comprises administering an effective amount of a 1,2,4-triazine compound of the formula (I): ##STR70## wherein R.sup.1 is a substituted or unsubstituted phenyl group, or a substituted or unsubstituted heterocyclic group,R.sup.2 is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted 5- to 6-membered aromatic heterocyclic group, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted alkenyl group,X and R.sup.3 are the following (i) or (ii):(i) X is an oxygen atom or a sulfur atom, and R.sup.3 is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted 5- to 6-membered aromatic heterocyclic group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted alkenyl group;(ii) X is a group of the formula: --NR.sup.4 -- (R.sup.4 is a hydrogen atom, or a substituted or unsubstituted alkyl group), and R.sup.3 is the same as defined above, or R.sup.4 and R.sup.3 may combine together with the nitrogen atom to which they bond to form a substituted or unsubstituted nitrogen-containing heterocyclic group, or a pharmaceutically acceptable salt thereof, to a mammal in need of such treatment.