Patent ID: 6562806
Filing Date: 2003-05-13
Classification: A61P,C07D,Y02P

Abstract:
A compound with the formula I: wherein:R10 is selected from the group consisting of: (a) â€ƒwherein n is 0 to 3 and R(I) is H or R and R(II) is one or more substituents selected from NO2, OR and R, or a group of formula â€”Oâ€”(CH2)mâ€”Oâ€” attached to adjacent atoms, where m is 1 or 2, or wherein n is 0 to 3; R2 and R3 are independently selected from: H, R, OH, OR, &boxH;O, &boxH;CHâ€”R, &boxH;CH2, CH2â€”CO2R, CH2â€”CO2H, CH2â€”SO2R, Oâ€”SO2â€”R, CO2R, COR and CN; R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, nitro, Me3Sn; or R7 and R8 together form a group â€”Oâ€”(CH2)pâ€”Oâ€”, where p is 1 or 2; X is S, O or NH; R11 is either H or R; wherein R is a lower alkyl group having 1 to 10 carbon atoms, or an aralkyl group, of up to 12 carbon atoms, whereof the alkyl group optionally contains a carbonyl group or one or more carbon-carbon double or triple bonds, which may form part of a conjugated system, or an aryl group of up to 12 carbon atoms; and wherein R is optionally substituted by one or more halo, hydroxy, amino or nitro groups; and where there is optionally a double bond between C1 and C2 or C2 and C3; and R8 is selected from H, R, OH, OR, halo, amino, nitro, Me3Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula I, where the R8 groups of the monomers form together a bridge having the formula â€”Tâ€”Râ€²â€”Tâ€” linking the monomers, where Râ€² is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero atoms and/or aromatic rings, and may contain one or more carbon-carbon double or triple bonds, and each T is independently selected from O, S or N.