Patent ID: 6339062
Filing Date: 2002-01-15
Classification: A61K,C07K,Y02A

Abstract:
A polypeptide having the retroinverso form of a polypeptide of formula (I)Z1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Z2â€ƒâ€ƒ(SEQ ID NO: 3) wherein:Xaa2 is a neutral/non-polar/large/cyclic amino acid residue; Xaa3 is a neutral/polar/small or neutral/polar/large/non-cyclic or acidic amino acid residue; Xaa4 is a neutral/nonpolar/large/cyclic or neutral/non-polar/large/non-cyclic or neutral/polar/large/non-cyclic or neutral/polar/small amino acid residue; Xaa5 is a neutral/polar/small amino acid residue Xaa6 is a neutral/polar/small or neutral/polar/large/non-cyclic amino acid residue; Xaa7 is a neutral/nonpolar/large/non-cyclic or neutral/polar/large/non-cyclic amino acid residue; Xaa8 is a neutral/polar/large/non-cyclic or neutral/polar/small amino acid residue; Xaa9 is a neutral/polar/small amino acid residue; Xaa10 is a neutral/polar/small amino acid residue; Z1 is hydrogen, amino, acetyl or at least one amino acid residue or the desamino form thereof; Z2 is hydroxyl, carboxyl, non-amino acids such as agmatine, or at least one amino acid residue, including carboxyamide or alkylamide forms thereof; and wherein said polypeptide mimics or inhibits the biological activity of thrombospondin.