Patent ID: 6509163
Filing Date: 2003-01-21
Classification: C07K

Abstract:
A method of screening a compound for its ability to modulate the permeabilizing activity of a mammalian P2X7 receptor having the amino acid sequence of SEQ ID NO:17, 18 or 20 comprising:contacting a cell, which is transformed with a construct comprising SEQ ID NO:17, 18 or 20 and expresses said P2X7 receptor, with a P2X7 receptor agonist, in the presence and absence of said compound, and assaying for an alteration in the permeabilizing activity of said P2X7 receptor in the presence of said compound, and a reduction or increase in the permeabilizing activity of said P2X7 receptor being indicative of a compound that modulates P2X7 receptor permeabilizing activity.