Patent ID: 6825166
Filing Date: 2004-11-30
Classification: A61K,A61P,C07D,C07H,C07J,C07K

Abstract:
A molecular conjugate having the formula: wherein:(a) n is a conjugation number of said molecular conjugate; (b) P is a de-amino moiety of a molecule having at least n accessible amino functionalities; (c) R1 is selected from: (1) a de-hydroxyl moiety of (i) a hydroxyl-bearing biologically active molecule and analogs and derivatives thereof of formula R1â€”OH, and (2) a de-amino moiety of (i) an amino-bearing biologically active molecule and analogs and derivatives thereof of formula R1â€”NH2 or a salt or secondary amine thereof; (d) where Z is â€”Oâ€” when R1 is said de-hydroxyl moiety and Z is â€”NHâ€” when R1 is said de-amino moiety; and (e) Y is selected from: (1) a straight or branched alkyl having 1 to 20 carbons optionally substituted with one or more phenyl, (2) a cycloalkyl optionally substituted with one or more alkyl or phenyl, and (3) an aromatic group optionally substituted with one or more alkyl, electron-withdrawing or electron-donating groups.