Patent ID: 6528093
Filing Date: 2003-03-04
Classification: A61K,A61P,C07K

Abstract:
A method of producing a plurality of microcapsules together constituting a sustained-release preparation of leuprorelin which comprises:(a) dissolving or suspending leuprorelin in an organic solvent solution comprising an organic solvent selected from the group consisting of halogenated hydrocarbons, alkyl ethers having three or more carbon atoms, alkyl esters of carboxylic acids wherein the alkyl group has four or more carbon atoms, aromatic hydrocarbons and mixtures thereof and a biodegradable polymer comprising a copolymer of lactic acid and glycolic acid to form a mixture; (b) adding the mixture to an aqueous medium to provide an O/W emulsion; and (c) transforming the mixture into microcapsules by removal of the organic solvent.