Patent ID: 8790697
Filing Date: 2014-07-29
Classification: A61K,C01B

Abstract:
1. A controlled release delivery system comprising a bio-active compound and a matrix carrier, wherein said matrix carrier is an amorphous microporous non-fibrous silicon or titanium oxide that is non-erodible, being loaded with said bio-active compound, said controlled release delivery system having been prepared by first synthesizing said amorphous micro-porous non-fibrous oxide matrix carrier, in the absence of a bio-active compound, said synthesis optionally comprising a calcination step, and then loading said bioactive agent into said matrix carrier, wherein the matrix carrier has a BET surface area of at least 150 m2/g and at most 1,000 m2/g, wherein the matrix carrier has a monomodal micropore size distribution, a micropore volume of at least 0.10 cm3/g and at most 0.52 cm3/g, wherein the micropores of said matrix carrier have a mean size in the range of 0.4 to 2.0 nm, wherein an 80% release of said bio-active compound into an aqueous fluid at a pH between 1.0 and 8.0 is not obtained before a period of time ranging from 2 hours to about 150 hours, and wherein the release of the first 80% of the bioactive compound occurs linearly with the square root of time.