Patent ID: 6451859
Filing Date: 2002-09-17
Classification: A61P,C07C,C07D

Abstract:
A compound having the structure: wherein(a) R1 is selected from the group consisting of CO2H, C(O)NHOH, CO2R2, CH2OH, S(O)2R2, C(O)NHR2, C(O)NHS(O)2R2, or tetrazole; wherein R2 is alkyl, heteroalkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, monocyclic aromatic ring, or monocyclic heteroaromatic ring; (b) X is selected from the group consisting of CH&boxH;C&boxH;CH, CH&boxH;CH, CH&boxH;N, C(O) and C(O)Y; wherein Y is selected from the group consisting of O, S and NH; (c) Z is an aromatic ring or a heteroaromatic ring provided that when Z is a heteroaromatic ring Z is attached via a Carbon member atom; and (d) any optical isomer, diastereomer, entinaomer of the above structure or a pharmaceutically-acceptable salt, or bio-hydrolyzable amide, ester, or imide thereof.