Patent ID: 6624177
Filing Date: 2003-09-23
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound of Formula VII or a pharmaceutically acceptable salt thereof wherein:R2 and R4 are independently hydrogen, â€”C1-C5 alkyl, phenyl â€”NO2, halogen, â€”OR5, â€”CN, â€”CO2R5, â€”SO3R5, â€”CHO, â€”COR5, â€”CONR5R6, â€”(CH2)nNR5R6, â€”CF3, or â€”NHCOR5, wherein each R5 and R6 are independently hydrogen or C1-C5 alkyl; M is a natural (L) alpha amino acid derivative having the structure wherein Ra is hydroxy, C1 to C6 straight or branched chain alkoxy, C5 to C7 cycloalkoxy, arylalkoxy, NH2, primary C1 to C6 alkyl amino, secondary C1 to C6 dialkyl amino wherein the alkyl groups are straight or branched chain, secondary amino having a 5- or 6-membered heterocycle which is pyrrolidinyl or piperidinyl, or â€”NHOR5; Rb is a side chain of a natural alpha amino acid; n is 0 to 2; and provided that R2 and R4 are not both H when M is tryptophan.