Patent ID: 8362002
Filing Date: 2013-01-29
Classification: A61P,C07D

Abstract:
1. A method of treating a disease, wherein treating means inhibiting the disease, and wherein the disease is a cancer selected from melanoma, colorectal cancer, pancreatic cancer, breast cancer, non-small cell lung cancer, small cell lung cancer, papillary and anaplastic thyroid cancer, endometrial cancer, and ovarian cancer, comprising administering to a patient a therapeutically effective amount of a compound of formula I, or a single stereoisomer or mixture of stereoisomers thereof and optionally as a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I, or a single stereoisomer or mixture of stereoisomers thereof and optionally as a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient, or diluent, wherein the compound of formula I is: or wherein A, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined in Group A, Group B, Group C, or Group D: Group A: A is phenylene optionally substituted with one, two, three or four groups selected from R X is alkyl, halo, haloalkyl, or haloalkoxy; R m is 0, 1, or 2; R R R R R Group B: A is heteroarylene optionally substituted with one, two, three, or four groups selected from R X is alkyl, halo, haloalkyl, or haloalkoxy; R m is 1 or 2; R R R R Group C: A is where R R Y X is alkyl, halo, haloalkyl, or haloalkoxy; R m is 1 or 2; R R R R Group D: A is R X is alkyl, halo, haloalkyl, or haloalkoxy; R m is 1 or 2; R R R R