Patent ID: 7288544
Filing Date: 2007-10-30
Classification: A61K,A61P,C07D

Abstract:
1. A pyrimidine compound of formula (1), or a pharmaceutically acceptable salt thereof: wherein A represents a group of formula (2), or 1-naphthyl, 2-naphthyl, indole-2-yl, indole-3-yl, thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl or pyridine-2-yl group: wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different from each other and each represent hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkenyl group, a lower alkynyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoyl group, a lower alkoxycarbonyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkoxyl group, a hydroxy-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkoxyl group, a halogeno-lower alkenyl group, an aryl-lower alkoxyl group or an aroyl group, C represents a hydrogen atom, a lower alkyl group, a lower alkylamino group, a lower alkylthio group, a lower alkyl sulfinyl group, a lower alkyl sulfonyl group, a lower alkoxyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkylamino group, a hydroxy-lower alkylthio group, a hydroxy-lower alkoxyl group, an amino-lower alkyl group, an amino-lower alkylamino group, an amino-lower alkylthio group, an amino-lower alkoxyl group, an aryl-lower alkyl group, an aryl-lower alkylamino group, an aryl-lower alkylthio group, an aryl-lower alkoxyl group, a heteroaryl-lower alkyl group, a heteroaryl-lower alkylamino group, a heteroaryl-lower alkylthio group, a heteroaryl-lower alkoxyl group, a halogeno-lower alkyl group, a halogeno-lower alkylamino group, a halogeno-lower alkylthio group, a halogeno-lower alkoxyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted cyclic alkyl group, a lower alkyl group substituted with a substituted or unsubstituted cyclic alkyl group, a substituted or unsubstituted aryloxy group or a substituted or unsubstituted heteroaryloxy group, E represents a hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, an aryl-lower alkyl group, a heteroaryl-lower alkyl group, a hydroxy-lower alkyl group, an amino-lower alkyl group, a halogeno-lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group or a group of formula (3) or (4): wherein X 2 represents O, S or N—R 8 , n represents an integer of 1 to 6, K in formula (3) represents a hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, nitro group or azido group, G in formula (4) represents N or C—H, wherein R 6 to R 8 may be the same or different from each other, and each represents a hydrogen atom, a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 1 to 6 carbon atoms, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, an amino-lower alkyl group, an amino-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkenyl group, an aryl-lower alkyl group, an aryl-lower alkenyl group, a heteroaryl-lower alkyl group, a heteroaryl-lower alkenyl group, a cyano-lower alkyl group or a cyano-lower alkenyl group, and the chains may contain a hetero atom, or R 6 and R 7 may together form a ring which may contain a hetero atom, F represents thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, or a group of formula (5): wherein R X Y represents a saturated or unsaturated linear hydrocarbon group having 3 to 4 carbon atoms, which may contain a hetero atom in the group thereof, or a group of formula (6): wherein R 15 represents a hydrogen atom, a substituted or unsubstituted, saturated or unsaturated linear, branched or cyclic hydrocarbon group having 1 to 6 carbon atoms, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, an amino-lower alkyl group, an amino-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkenyl group, an aryl-lower alkyl group, an aryl-lower alkenyl group, a heteroaryl-lower alkyl group, a heteroaryl-lower alkenyl group, a cyano-lower alkyl group or a cyano-lower alkenyl group, and the chains of R 15 may contain a hetero atom, and m represents an integer of 2 to 3.