Patent ID: 8741849
Filing Date: 2014-06-03
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting a kinase activity of a Ca2+/calmodulin-dependent protein kinase I (CaMKI) family kinase, the method comprising the step of providing a kinase inhibiting composition, wherein the kinase inhibiting composition comprises an inhibitory amount of a kinase inhibiting peptide, wherein the kinase inhibiting peptide comprises an amino acid sequence according to Formula VI: wherein each of Z1 and Z2 is absent or is a transduction domain; X1 is KA; X2 is L; X3 is A; X4 is R; X5 is selected from the group consisting of Q and N; X6 is L; X7 is G; X8 is V; X9 is A; X10 is A, and wherein the Ca2+/calmodulin-dependent protein kinase I (CaMKI) family kinase contacts the kinase inhibiting composition, and wherein the activity of the Ca2+/calmodulin-dependent protein kinase I (CaMKI) family kinase is inhibited.