Patent ID: 6809086
Filing Date: 2004-10-26
Classification: A61K,A61P,C08B

Abstract:
A method of increasing proliferation of cells which comprises adding to cells a cellular proliferating amount of a product of a sulfated primary hydroxyl group of N-acetylglucosamine selectively desulfated heparin having the following characteristics:(1) contents of unsaturated disaccharides of the following formulae (a) and (b): measured by high performance liquid chromatography in the enzyme digestion product of the selectively desulfated heparin are less than 40% and 30 to 67%, respectively,(2) a content of disaccharides containing an N-substituted sulfate group is 75 to 95%, and (3) the weight average molecular weight Mw of said product is 4,000 to 30,000 dalton.