Patent ID: 6660303
Filing Date: 2003-12-09
Classification: A61K

Abstract:
A method of obtaining a highly compactible, superdisintegrating drug-ready complex, comprising:co-transforming amorphous regions of amylose/amylo-pectin superdisintegrant material in etherified granules using lubricant-binder emulsion technology, said amorphous regions are transformed into crystalline regions, wherein the step of co-transforming using lubricant-binder technology comprises: a) preparing a hot or heated colloidal solution of an augmenting agent; b) adding to said solution said amylose/amylo-pectin superdisintegrant material to form a stirrable suspension at a temperature sufficient to allow said superdisintegrant to swell without bursting; c) filtering said stirrable suspension; and d) drying said stirrable suspension, to obtain said superdisintegrating drug-ready complex.