Patent ID: 6759425
Filing Date: 2004-07-06
Classification: A61K,C07D

Abstract:
A pharmaceutical composition for treating allergic reaction associated with increased IgE levels in a mammal comprising any one or more of the following compounds: wherein R is selected from the group consisting of H, C1-C5 alkyl, benzyl, p-fluorobenzyl and di-alkylamino alkyl, wherein said C1-C5 alkyl is selected from the group consisting of a straight chain, branched or cyclic alkyl; wherein R1 and R2 are independently selected from the group consisting of H, pyridyl, substituted pyridyl, pyridyl-N-oxide, adamantyl and substituted adamantyl; provided one of R1 and R2 is an adamantyl or a substituted adamantyl; wherein substituents on substituted adamantyl and substituted pyridyl are independently selected from the group consisting of H, halogens, polyhalogens, alkoxy group, substituted alkoxy, alkyl, substituted alkyl, dialkylaminoalkyl, hydroxyalkyl, carbonyl, OH, OCH3, COOH, OCORâ€², COORâ€², CORâ€², CN, CF3, OCF3, NO2, NRâ€²Râ€², NHCORâ€² and CONRâ€²Râ€²; wherein Râ€² is selected from the group consisting of H, alkyl, substituted alkyl, C3-C9 cycloalkyl, substituted C3-C9 cycloalkyl, polycyclic aliphatics, substituted polycyclic aliphatics, phenyl, substituted phenyl, naphthyl, substituted naphthyl, heteroaryl and substituted heteroaryl, wherein said heteroaryl and said substituted heteroaryl contain 1-3 heteroatoms, wherein said heteroatom is independently selected from the group consisting of nitrogen, oxygen and sulfur; wherein X and Y are independently selected from the group consisting of H, halogens, alkoxy, substituted alkoxy, alkyl, substituted alkyl, dialkylaminoalkyl, hydroxyalkyl, OH, OCORâ€³, OCH3, COOH, CN, CF3, OCF3, NO2, COORâ€³, CHO and CORâ€³; and wherein Râ€³ is a C1-C8 alkyl, wherein said C1-C8 alkyl is selected from the group consisting of a straight chain, branched or cyclic alkyl.