Patent ID: 8597900
Filing Date: 2013-12-03
Classification: A01K,C07K,C12Q,G01N

Abstract:
1. A method comprising: (a) collecting a sample from a subject with a neoplastic disorder, wherein said subject has been exposed to a genotoxic anti-neoplastic agent; (b) measuring the degree of ubiquitination of FANCD2 polypeptide in said subject sample; (c) measuring the degree of ubiquitination of FANCD2 polypeptide in a control sample that has been exposed to said genotoxic anti-neoplastic agent; (d) comparing the degree of ubiquitination of FANCD2 polypeptide in (b) with the degree of ubiquitination of FANCD2 polypeptide in (c); and (e) determining said subject is sensitive to said genotoxic anti-neoplastic agent when the degree of ubiquitination of FANCD2 polypeptide measured in (b) is less than the degree of ubiquitination of FANCD2 polypeptide measured in (c).