Patent ID: 6955884
Filing Date: 2005-10-18
Classification: A61P,C07K,C12N,C12Y

Abstract:
1. A method for identifying a compound that inhibits CD38 enzyme activity comprising (i) contacting a cell expressing CD38 and a chemoattractant receptor with a test compound in the presence of a chemoattractant and substrate and measuring the level of CD38 activity; (ii) in a separate experiment, contacting a cell expressing CD38 and a chemoattractant receptor with a vehicle control in the presence of a chemoattractant and substrate and measuring the level of CD38 activity where the conditions are essentially the same as in part (i); and then (iii) comparing the level of CD38 activity measured in part (i) with the level of CD38 activity in part (ii), wherein a decrease in the level of CD38 activity in the presence of the test compound indicates that the test compound is a CD38 inhibitor.