Patent ID: 6528685
Filing Date: 2003-03-04
Classification: A61K,C07C

Abstract:
A method for providing protection against epilepsy convulsions or seizures in a subject in need of such protection comprising administering to the subject an amount of a compound effective to provide such protection, wherein the compound has the formula: wherein n is 0, 1 or 2; each of R1 and R2 are independently hydrogen, hydroxy, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 alkoxy, halogen, nitro, â€”NHâ€”R11, â€”C(O) â€”NR9R10,wherein R11 is hydrogen, substituted or unsubstituted C1-C4 alkyl, hydroxy, substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted C6-C12 aryl; and each of R9 and R10 are independently hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, or indanyl; R3 is hydrogen, substituted or unsubstituted C1-C4 alkyl, hydroxy, substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted C6-C12 aryl; each of R4 and R5 are independently hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, â€”C(O)â€”R6, â€”Yâ€”C(O)â€”R7 or Yâ€”(SO2)NR9R10;wherein R6 is hydrogen, hydroxy, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, or Aâ€”NR9R10, wherein A is substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, and each of R9 and R10 are independently hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, or indanyl; Y is substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, and R7 is hydrogen, hydroxy, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, or NR9R10,wherein each of R9 and R10 are independently hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl or indanyl; and racemic mixtures, enantiomers, and salts thereof.