Patent ID: 8822727
Filing Date: 2014-09-02
Classification: C07C

Abstract:
1. A process for preparing 2-chloro-N-(4-chlorophenethyl)propan-1-amine hydrochloride comprising the steps: a) reacting hydrogen bromide with 2-(4-chlorophenyl)ethanol to form 2-(4-chlorophenyl)ethyl bromide by adding said hydrogen bromide as a gas to said 2-(4-chlorophenyl)ethanol at a temperature from about 60° C. to about 100° C. and at a pressure from about −1.00 bar to about +2.00 bar in the absence of an added solvent; b) reacting said 2-(4-chlorophenyl)ethyl bromide with 1-aminopropan-2-ol to form 1-(4-chlorophenethylamino)propan-2-ol; and c) reacting said 1-(4-chlorophenethylamino)propan-2-ol with thionyl chloride to form 2-chloro-N-(4-chlorophenethyl)propan-1-amine hydrochloride.