Patent ID: 8008023
Filing Date: 2011-08-30
Classification: A61P,G01N

Abstract:
1. A method of identifying an agent that binds to a RCC356 polypeptide, wherein said RCC356 polypeptide comprises SEQ ID NO: 5, said method comprising: a) contacting said RCC356 polypeptide with isovaleric acid in the presence or in the absence of a candidate modulator under conditions permitting the binding of said isovaleric acid to said RCC356 polypeptide; wherein said contacting is performed in or on a cell expressing said RCC356 polypeptide, performed in or on synthetic liposomes, or performed in or on virus-induced budding membranes containing said RCC356 polypeptide polypeptide, and b) measuring the binding of said RCC356 polypeptide to said isovaleric acid, wherein a decrease in binding in the presence of said candidate modulator, relative to the binding in the absence of said candidate modulator, identifies said candidate modulator as an agent that modulates the function of said RCC356 polypeptide.