Patent ID: 7544674
Filing Date: 2009-06-09
Classification: A61K,A61P,A61Q

Abstract:
1. A method of making a topical medicated composition comprising water, hydrophilic compounds and hydrophobic compounds, and active ingredients consisting of fluocinolone acetonide, hydroquinone and tretinoin, the method comprising: (a) mixing water and at least one hydrophilic compound to form an aqueous composition; (b) mixing at least two hydrophobic compounds to form a non-aqueous composition; (c) mixing the aqueous composition and the non-aqueous composition to form a mixture, said steps (a) through (c) being conducted in the absence of an emulsifier; (d) mixing the fluocinolone acetonide and the tretinoin into the mixture of step (c); (e) adding at least one emulsifier after step (c) into the mixture of step (c), or during step (d); and thereafter (f) homogenizing the mixture; wherein the hydroquinone is added in step (d) after adding the at least one emulsifier.