Patent ID: 6825354
Filing Date: 2004-11-30
Classification: C07C,C07D

Abstract:
A compound of formula wherein: R1 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, or C5-C8-cycloheteroalkyl having from 1-2 heteroatoms selected from N, NR7, S and O; R2 and R3 are each independently, hydrogen, alkyl of 1-6 carbon atoms, â€”CN, or â€”CCH; R5 is hydrogen, alkyl of 1-8 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl, or C4-C8-cycloheteroalkyl; R7 is hydrogen, aryl, aralkyl, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-6 carbon atoms, oxy, C1-C8 alkanoyl, COOR5, COR5, â€”SO2â€”C1-C8 alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, â€”COâ€”NHR1; R8, R9, R10, and R11 are each, independently, hydrogen, aryl, aralkyl, 5-10 membered heteroaryl having from 1-3 heteroatoms selected from N, NR7, O and S, heteroaralkyl having from 1-3 heteroatoms selected from N, NR7, O and S, cycloalkyl of 3-6 carbon atoms, â€”C4-C8-cycloheteroalkyl having from 1-3 heteroatoms selected from N, NR7, O and S, alkyl of 1-18 carbon atoms, alkenyl of 2-18 carbon atoms, alkynyl of 2-18 carbon atoms; R12 is hydrogen, aryl or 5-10 membered heteroaryl having from 1-3 heteroatoms selected from N, NR7, S and O, cycloalkyl of 3-6 carbon atoms, â€”C5-C8-cycloheteroalkyl having from 1 to 2 heteroatoms selected from N, NR7, S and O, or alkyl of 1-6 carbon atoms; A is O, S, SO, SO2, NR7, or CH2; X is O, S, SO, SO2, NR7, or CH2; Y is heteroaryl, with the proviso that A and X are not bonded to adjacent atoms of Y; and n is 0-2; or a pharmaceutically acceptable salt thereof.