Patent ID: 7041845
Filing Date: 2006-05-09
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing an optically active 5-hydroxy-3-ketoester of the formula A1 or A2 or one of the tautomers thereof, wherein R R wherein R 1 , R 2 and R 3 are as hereinbefore defined, is resolved into the two enantiomeric 5-hydroxy-3-ketoester A1 and A2 by preparative high performance liquid chromatography (HPLC) over a chiral carrier material, wherein the chiral carrier material is selected from the group consisting of tris(3,5-dimethylphenylcarbamate) -amylose, tris[(S)-α-methylbenzvlcarbamate]-amylose, tris(3,5-dimethyphenylcarbamate) -cellulose, tris(4-methylbenzoate)-cellulose, cellulose triacetate, cellulosetribenzoate, tris(phenylcarbamate)-cellulose, tris(4-chlorophenylcarbamate)-cellulose, cellulosetricinnamate and cellulosetribenzoate.