Patent ID: 6329372
Filing Date: 2001-12-11
Classification: A61P,C07D

Abstract:
A compound of formula (1): ##STR6##wherein:R.sup.1 is an optionally substituted C.sub.6 -C.sub.12 aromatic group or a C.sub.1 -C.sub.9 heteroaromatic group containing one, two, three, or four heteroatoms selected from oxygen, sulphur or nitrogen;R.sup.2 is a hydrogen atom or methyl group;R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or a straight or branched alkyl group;R is a carboxylic acid group (--CO.sub.2 H) or an ester or amide deriviate thereof;Alk.sup.1 is an optionally substituted aliphatic chain;Alk.sup.2 is a straight or branched alkylene chain;L.sup.1 is linker atom or group from --O--, --S--, --C(O)--, --C(O)O--, --C(S)--, --S(O)--, --S(O).sub.2 --, --N(R.sup.4)--, --OC(O)N(R.sup.4)--, --CSN(R.sup.4)--, --C(O)N(R.sup.4)--, --N(R.sup.4)CO--, --N(R.sup.4)C(O)O--, --N(R.sup.4)CS--, --S(O)N(R.sup.4)--, --S(O).sub.2 N(R.sup.4)--, --N(R.sup.4)S(O)--, N(R.sup.4)S(O).sub.2 --, --N(R.sup.4)CON(R.sup.4)--, --N(R.sup.4)CSN(R.sup.4)--, --N(R.sup.4)SON(R.sup.4)-- and --N(R.sup.4)SO.sub.2 N(R.sup.4)--;R.sup.a and R.sup.b, which may be the same or different, is each an atom or group --L.sup.2 (CH.sub.2).sub.p L.sup.3 (R.sup.c).sub.q ;L.sup.2 and L.sup.3 are each covalent bond;R.sup.c is hydrogen or halogen atom or a group selected from straight or branched alkyl, --OR.sup.d, --SR.sup.d, --NR.sup.d R.sup.e, --NO.sub.2, --CN, --CO.sub.2 R.sup.d, --SO.sub.3 H, --SO.sub.2 R.sup.d, --OCO.sub.2 R.sup.d, --CONR.sup.d R.sup.e, --OCONR.sup.d R.sup.e, --CSNR.sup.d R.sup.e, --COR.sup.d, --N(R.sup.d)COR.sup.e, --N(R.sup.d)CSR.sup.e, --SO.sub.2 N(R.sup.d)(R.sup.e), --N(R.sup.d)SO.sub.2 R.sup.e, --N(R.sup.d)CONR.sup.e R.sup.f, --N(R.sup.d)CSNR.sup.e R.sup.f or --N(R.sup.d)SO.sub.2 NR.sup.e R.sup.f. ;R.sup.d, R.sup.e and R.sup.f, which may be the same or different, is each a hydrogen atom or an optionally substituted straight or branched alkyl group;p is zero or the integer 1;q is an integer 1, 2 or 3;m is zero or an integer 1;r and s, which may be the same or different, is each zero or an integer 1; andHet is an optionally substituted C.sub.3-5 monocyclic heteroaromatic group containing one, two or three heteroatoms selected from oxygen, sulphur or nitrogen atoms;with the proviso that when L.sup.1 is --C(O)N(R.sup.4)-- and is 1, r is other than 0;or the salts, solvates, hydrates, or N-oxides thereof.