Patent ID: 6720438
Filing Date: 2004-04-13
Classification: A61P,C07C

Abstract:
A process for the preparation of Latanoprost [1]which comprises deriving the compound [5]to give the compound [7]which is hydrogenated in the presence of catalyst to give the compound of the Formula [9]which is reduced with diisobutylaluminum hydride at temperature range from âˆ’50 to +50Â° C. followed by hydrolysis of the obtained reaction mixture under basic conditions to give compound [11], which is converted into latanoprost [1]werein one of R1 and R2 is an aryl carbonyl and the other one is selected from the group consisting of aryl carbonyl, acyl, trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted and alkyl-substituted tetrahydro-2H-pyran-2-yl and tetrahydrofuran-2-yl groups, and R3 is hydrogen when R1 is acyl and is equal to R1 when it is trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl groups; R4 is hydrogen when R2 is acyl and is equal to R2 when it is trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl groups.