Patent ID: 6294580
Filing Date: 2001-09-25
Classification: A61K,A61P,C07C,C07D

Abstract:
A compound having the formula (I): ##STR26##whereinA is selected from the group consisting of:(i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C.sub.1-6 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 fluoroalkoxy, nitrile, or --NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are independently hydrogen or C.sub.1-3 alkyl;(ii) a 5- or 6-membered heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur; and(iii) a fused bicyclic ring ##STR27##wherein ring C represents a heterocyclic group as defined in point (ii) above, which bicyclic ring is attached to group B via a ring atom of ring C;B is selected from the group consisting of:--MC.sub.1-6 alkylene or C.sub.1-6 alkyleneMC.sub.1-6 alkylene, wherein M is O, S, or --NR.sup.2 wherein R.sup.2 represents hydrogen or C.sub.1-3 alkyl; andHet-C.sub.1-6 alkylene, wherein Het represents a 5- or 6-membered heterocyclic group containing at least one nitrogen heteroatom and optionally at least one further heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by C.sub.13 alkyl;Alk represents C.sub.1-3 alkylene;R.sup.1 represents hydrogen or C.sub.1-3 alkyl;Z is --NR.sup.3 R.sup.4, wherein R.sup.3 represents hydrogen or C.sub.1-3 alkyl, and R.sup.4 represents --Y--(C.dbd.O)--T--R.sup.5, or --Y--(CH(OH))--T--R.sup.5, wherein:(a) Y represents a phenyl optionally substituted by one or more C.sub.1-3 alkyl groups and/or one or more halogen atoms;(b) T represents a bond, C.sub.1-3 alkyleneoxy, --O-- or --N(R.sup.6)--, wherein R.sup.6 represents hydrogen or C.sub.1-3 alkyl;(c) RI represents C.sub.1-6 alkyl, C.sub.4-6 cycloalkyl or cycloalkenyl, phenyl (optionally substituted by one or more: halogen atoms, C.sub.1-3 alkyl, C.sub.1-3 alkoxy groups, C.sub.0-3 alkyleneNR.sup.9 R.sup.10 where each R.sup.9 and R.sup.10 is independently hydrogen, C.sub.1-3 alkyl, --SO.sub.2 C.sub.1-3 alkyl, or --CO.sub.2 C.sub.1-3 alkyl, --SO.sub.2 NHC.sub.1-3 alkyl, C.sub.0-3 alkyleneCO.sub.2 H, C.sub.0-3 alkyleneCO.sub.2 C.sub.1-3 alkyl, or --OCH.sub.2 C(O)NH.sub.2), a 5- or 6-membered heterocyclic group as defined in point (ii) above,or a bicylic fused ring ##STR28##wherein ring D represents a 5- or 6-membered heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by (.dbd.O), which bicyclic ring is attached to T via a ring atom of ring D, or --C.sub.1-6 alkyleneMR.sup.11 M is O, S, or --NR.sup.2 wherein R.sup.2 and R.sup.11 are independently hydrogen or C.sub.1-3 alkyl;or a tautomeric form thereof, and/or a pharmaceutically acceptable salt or solvate thereof.