Patent ID: 6600028
Filing Date: 2003-07-29
Classification: A61P,C07D,C07H

Abstract:
A compound having the structure (2) whereinW is an alkylenyl or an alkenylenyl chain with 0-2 carbon atoms any of which may carry a substituent R8, X is selected from the group consisting of O, N, NR12 and CR10, Xâ€² is selected from the group consisting of O, S, NH, and N, and when Xâ€² is N, tautomers of structures (3) and (4) are present, â€ƒwhen Xâ€² is O or S, X is C, Y is CH or N, R6 is selected from the group consisting of H, NH2, SCH3, SO2CH3 and NHNH2, R7 and R8 are independently selected from the group consisting of H, F, alkyl, alkenyl, aryl, acyl and a reporter moiety, R9 and R12 are independently selected from the group consisting of H, alkyl, alkenyl, aryl, acyl, and a reporter moiety, R10 is selected from the group consisting of H, &boxH;O, F, alkyl, alkenyl, aryl, acyl and a reporter moiety, the dashed line in structure (2) indicates an optional double bond, Q is selected from the group consisting of H, â€ƒwherein R is selected from the group consisting of CH3, CH2OH and H, Z is selected from the group consisting of O, S, SO, and CH2, R1, R3 and R4 are independently selected from the group consisting of H, OH, F, NH2, N3, O-hydrocarbyl, and a reporter moiety, R2 is selected from the group consisting of H, OH, F, NH2, N3, O-hydrocarbyl, a report moiety, phosphoramidite, H-phosphonate, methylphosphonate and phosphorothioate, R5 is selected from the group consisting of OH, SH, NH2, monophosphate, diphosphate, triphosphate, thiophosphate, boranophosphate, phosphoramidite, H-phosphonate, methylphosphonate, and phosphorothioate, and at least one of R2 and R5 being selected from the group consisting of phosphoramidite, H-phosphonate, methylphosphonate, and phosphorothioate.