Patent ID: 6299884
Filing Date: 2001-10-09
Classification: A61K,A61P,Y02A,Y10S

Abstract:
A method of stimulating an immune response in a host animal comprising:administering an antigen to said animal in the presence of an immunostimulating amount of an adjuvant composition consisting essentially of:(1) a metabolizable oil, wherein the oil is present in an amount of 0.5% to 20% of the total volume and(2) an emulsifying agent, wherein the emulsifying agent is 0.01% to 2.5% by weight (w/w), and wherein said oil and said emulsifying agent are present in the form of an oil-in-water emulsion having oil droplets substantially all of which are about 100 nm to less than 500 nm in diameter and wherein said composition exists in the absence of any polyoxypropylene-polyoxyethylene block copolymer and in the absence of any muramyl peptide, and further wherein said adjuvant composition is capable of increasing the immune response to said antigen.