Patent ID: 6670480
Filing Date: 2003-12-30
Classification: A61P,C07F,Y02P

Abstract:
A compound of the formula wherein n is 0, 1, 2 or 3;R1 is hydrogen or halo; each R2 is independently hydrogen, halo, trifluoromethyl, cyano, SR4, OR4, SO2R4, OCOR5, or (C1-C10)alkyl wherein the alkyl group is optionally substituted by hydroxy, halo, cyano, N(R4)2, SR4, trifluoromethyl, OR4, (C3-C8)cycloalkyl, (C6-C10)aryl, NR4COR5, COL5, So2R5, OCOR5, NR4SO2R5 and NR4CO2R4; R4 and R5, for each occurrence, are each independently selected from hydrogen, (C1-C10)alkyl, (C1-C10)alkoxy, (C3-C8)cycloalkyl,(C6-C10)aryl, (C2-C9)heterocycloalkyl, (C2-C9)heteroaryl or (C1-C6)aryl wherein the alkyl group is optionally substituted by the group consisting of hydroxy, halo, carboxy, (C1-C10)allcyl-CO2, (C1-C10)alkylsulfonyl, (C3-C8)cycloalkyl, (C1-C10)alkoxy, or (C1-C6)alkyl; and wherein the aryl, heterocycloalkyl and heteroaryl groups are optionally substituted by one to four groups consisting of halo, nitro, oxo, ((C1-C6)alkyl)2amino, pyrrolidine, piperidine, (C1-C10)alkyl, (C1-C10)alkoxy, (C1-C10)alkylthio and (C1-C10)alkyl wherein the alkyl group is optionally substituted by one to four groups selected from hydroxy, halo, carboxy, (C1-C6)alkyl-CO2, (C1-C6)alkylsulfonyl, (C3-C8)cycloalkyl and (C1-C6)alkoxy; or R5 is N(R4)2 wherein R4 is as defined above; Provided that:1) R1 and R2 are not both hydrogen; and 2) when R1 is hydrogen and n is 2, then the two R2 groups are not methyl and cyano.