Patent ID: 6420375
Filing Date: 2002-07-16
Classification: C07D

Abstract:
A compound of the formula: whereinA1 is (1) a C6 cycloalkene or (2) benzene, each of which is unsubstituted or substituted by one to three substituents selected from the group consisting of 1) a C1-6 alkyl group, 2) a C1-6 alkyl group substituted by a halogen, a C1-3 alkoxy, hydroxyl, amino or an amino group substituted by a C1-3 alkyl, 3) a C1-6 alkoxy group, 4) a C1-6 alkoxy group substituted by a halogen, a C1-3 alkoxy, hydroxyl, amino or an amino group substituted by a C1-3 alkyl, 5) a carboxyl group, 6) a C1-6 alkoxy-carbonyl, 7) carbamoyl, 8) a carbamoyl group substituted by one or two of C1-6 alkyl groups which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of (1) a halogen, (2) an C1-4 alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an C1-4 alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) nitro, 9) thiocarbamoyl, 10) a thiocarbamoyl group substituted by one or two of C1-6 alkyl groups which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of (1) a halogen, (2) an C1-4 alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an C1-4 alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) nitro, 11) amino, 12) an amino group substituted by one or two of C1-6 alkyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of (1) a halogen, (2) an C1-4 alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an C1-4 alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) nitro, 13) hydroxyl, 14) a hydroxyl substituted by a C1-6 alkyl which may have 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 15) thiol (mercapto), 16) a thiol unsubstituted or substituted by a C1-6 alkyl which may have 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 17) formyl, 18) a C1-6 alkyl carbonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, 19) a C1-6 sulfinyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, 20) a C1-6 sulfonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, 21) a halogen atom, 22) a nitro group, 23) a cyano group and 24) an oxo group, A2 is benzene, furan, thiophene or pyridine, each of which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of (1) a C1-6 alkyl group, (2) a C1-6 alkyl group substituted by 1 to three substituents selected from the group consisting of a halogen, a (C1-3)alkoxy, hydroxyl, amino, methylamino, dimethylamino and diethylamino, (3) a C1-6 alkoxy group, (4) a C1-6 alkoxy group substituted by 1 to three substituents selected from the group consisting of a halogen, a (C1-3)alkoxy, hydroxyl, amino, methylamino, dimethylamino and diethylamino, (5) a C6-10 aryl group, (6) a C6-10 aryl group substituted by substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (7) C4-7 cycloalkyl group, (8) C4-7 cycloalkyl group substituted by substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (9) a C3-6 cycloalkenyl group, (10) a C3-6 cycloalkenyl group substituted by substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (11) carboxyl, (12) a C1-6 alkoxy-carbonyl, (13) a C6-10 aryl-oxycarbonyl, (14) a C7-10 aralkyl-oxycarbonyl, (15) carbamoyl, (16) a carbamoyl group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (17) a cyclic amino-carbonyl whose cyclic amino is selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (18) thiocarbamoyl, (19) a thiocarbamoyl group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (20) a cyclic amino-thiocarbonyl whose cyclic amino is selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (21) amino, (22) an amino group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (23) a cyclic amino selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (24) hydroxyl, (25) a hydroxyl group substituted by 1) a C1-6 alkyl unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 2) a C3-6 cycloalkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 3) a C6-10 aryl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano or 4) a C7-12 aralkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, (26) thiol (mercapto), (27) a thiol (mercapto) group substituted by 1) a C1-6 alkyl unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 2) a C3-6 cycloalkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 3) a C6-10 aryl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano or 4) a C7-12 aralkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, (28) formyl, (29) a C1-6 alkyl carbonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (30) a C1-6 sulfinyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (31) a C1-6 sulfonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (32) a halogen atom, (33) nitro and (34) cyano, X is an C1-6 alkylene, Y is a methine group, Z is a group of the formula: â€”CR1&boxH;CR2â€”wherein each of R1 and R2 is selected from the group consisting of(1) a hydrogen atom, (2) a fluorine atom, (3) a C1-6 alkyl group, (4) a C1-6 alkyl group substituted by 1 to three substituents selected from the group consisting of a halogen, a (C1-3)alkoxy, hydroxyl, amino, methylamino, dimethylamino and diethylamino, (5) a C1-6 alkoxy group, (6) a C1-6 alkoxy group substituted by 1 to three substituents selected from the group consisting of a halogen, a (C1-3)alkoxy, hydroxyl, amino, methylamino, dimethylamino and diethylamino, (7) a C6-10 aryl group, (8) a C6-10 aryl group substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (9) a C4-7 cycloalkyl group, (10) a C4-7 cycloalkyl group substituted by substituted by 1 to 5 substituents selected from the group consisting of (1) halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (11) a C3-6 cycloalkenyl group, (12) a C3-6 cycloalkenyl group substituted by substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) a C1-3 alkyl group, (3) amino, (4) an amino group substituted by a C1-3 alkyl, (5) a hydroxyl group, (6) a nitro group and (7) a cyano group, (13) carboxyl, (14) a C1-6 alkoxy-carbonyl, (15) a C6-10 aryl-oxycarbonyl, (16) a C7-10 aralkyl-oxycarbonyl, (17) carbamoyl, (18) a carbamoyl group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (19) a cyclic amino-carbonyl whose cyclic amino is selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (20) thiocarbamoyl, (21) a thiocarbamoyl group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (22) a cyclic amino-thiocarbonyl whose cyclic amino is selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (23) amino, (24) an amino group substituted by one or two substituents selected from the group consisting of 1) a C1-6 alkyl unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 2) a C3-6 cycloalkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 3) a C6-10 aryl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, 4) a C7-12 aralkyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, and 5) a C6-10 arylsulfonyl group unsubstituted or substituted by one to five substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl group unsubstituted or substituted by 1 to 3 halogen atoms and (4) a nitro group, (25) a cyclic amino selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, piperidino, morpholino, thiomorpholino and 1-piperazinyl, (26) hydroxyl, (27) a hydroxyl group substituted by 1) a C1-6 alkyl unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 2) a C3-6 cycloalkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 3) a C6-10 aryl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano or 4) a C7-12 aralkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, (28) thiol (mercapto), (29) a thiol (mercapto) group substituted by 1) a C1-6 alkyl unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 2) a C3-6 cycloalkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, 3) a C6-10 aryl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano or 4) a C7-12 aralkyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of (1) a halogen, (2) an alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, (3) an alkyl unsubstituted or substituted by 1 to 3 halogen atoms, (4) nitro, (5) amino and (6) cyano, (30) formyl, (31) a C1-6 alkyl carbonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (32) a C1-6sulfinyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (33) a C1-6sulfonyl group unsubstituted or substituted by 1 to 5 substituents selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group, (34) a halogen atom, (35) nitro, (36) cyano, and R is an imidazolyl, a triazolyl or a pyridyl, each of which is unsubstituted or substituted by one to three substituents selected from the group consisting of 1) a C1-4 alkoxy group unsubstituted or substituted by 1 to 3 halogen atoms, 2) a halogen atom, 3) a C1-4 alkyl group unsubstituted or substituted by 1 to 3 halogen atoms, 4) an aryl group unsubstituted or substituted by a hydroxyl group, an amino group, a nitro group or a cyano group, and 5) nitro group, provided that 3,4-dihydro-6-[3-(1H-imidazol-1-yl)-1-propenyl]-2(1H)-quinolone and 2-[3-[5-ethyl-6-methyl-2-(benzyloxy)-3-pyridyl]-1-propenyl]benzoxazole are excluded, or a salt thereof.