Patent ID: 7901893
Filing Date: 2011-03-08
Classification: C07K,C12Q,G01N

Abstract:
1. A method for identifying a ligand of NPC1L1 comprising: (a) contacting human NPC1L1 with a candidate compound and a detectably labeled substituted 2-azetidinone glucuronide compound selected from the group consisting of compound 1, compound 8 and a compound of Formula II a wherein, R R R (b) measuring the amount of detectably labeled substituted 2-azetidinone glucuronide compound that is bound to NPC1L1, wherein binding of said candidate compound to human NPC1L1 decreases binding of said detectably labeled substituted 2-azetidinone glucuronide to human NPC1L1, and indicates that the candidate compound is a ligand of human NPC1L1.