Patent ID: 8809336
Filing Date: 2014-08-19
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a disease or condition comprising or arising from abnormal cell growth or abnormally arrested cell death in a mammal, wherein the disease or condition is selected from a carcinoma of the bladder, breast, colon, kidney, epidermal, liver, lung, oesophagus, gall bladder, ovary, pancreas, stomach, cervix, endometrium, thyroid, prostate, or skin; a hematopoietic tumour of lymphoid lineage; a hematopoietic tumour of myeloid lineage; a tumour of mesenchymal origin; a tumour of the central or peripheral nervous system; melanoma; seminoma; teratocarcinoma; osteosarcoma; xenoderoma pigmentosum; keratoctanthoma; thyroid follicular cancer; and Kaposi's sarcoma; which method comprises administering to the mammal a therapeutically effective amount of a compound of the formula (I): or a salt, tautomer or N-oxide thereof, wherein; T is N; J Q G is NR R R R E is a piperidine group bearing 0-1 substituents R R X provided that where the substituent group R