Patent ID: 6387896
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein:W is a) O, or b) S; X is a) â€”S(&boxH;O)mâ€”, or b) â€”NR3â€”; Y is a) â€”Oâ€”, b) â€”NHâ€”, c) â€”CH2â€”, or d) â€”S(&boxH;O)mâ€”; R1 is C1-4 alkyl, optionally substituted with 1-3 R5; R2 is a) H, b) C1-6 alkyl, optionally substituted with 1-3 halo; c) cyclopropyl, d) â€”OC1-4 alkyl, e) â€”NH2, f) â€”NHC1-6 alkyl, or g) â€”N(C1-6 alkyl)2; R3 is a) C1-8 alkyl, optionally substituted with 1-3 halo, CN, NO2, OH, SH or NH2, b) â€”C(&boxH;O)R4, or c) â€”C(&boxH;S)NHC1-4 alkyl; R4 is a) H, b) C1-6 alkyl, optionally substituted with OH, C1-4 alkoxy, NH2, SH or halo, or c) â€”CH2OC(&boxH;O)C1-4 alkyl; R5 is j) halo, k) â€”CN, l) â€”OH, m) â€”SH, n) â€”NH2, o) â€”OR6, p) â€”NHR6, q) â€”N(R6)2, or r) â€”S(&boxH;O)mR6; R6 is g) C1-6 alkyl, h) â€”C(&boxH;O)C1-4 alkyl, i) â€”C(&boxH;O)OC1-4 alkyl, j) â€”C(&boxH;O)NH2, k) â€”C(&boxH;O)NHC1-4 alkyl, or l) â€”SO2C1-4 alkyl; m is 0, 1, or 2; n is 0 or 1; with the proviso that were n is 0, Y is â€”CH2â€”.