Patent ID: 8337855
Filing Date: 2012-12-25
Classification: A61K,A61P,C07K

Abstract:
1. An isolated humanized antibody or fragment thereof, that specifically binds to CD33, said antibody, or fragment thereof, comprising at least one heavy chain (H) variable region and at least one light chain (L) variable region, wherein said heavy chain variable region comprises three complementarity-determining regions (CDRs) having the amino acid sequences of SEQ ID NOs:1 (CDRH1), 2 (CDRH2), and 3 (CDRH3), wherein for SEQ ID NO: 2, X is Q, and wherein said light chain variable regions comprises three complementarity-determining regions having the amino acid sequences of SEQ ID NOs:4 (CDRL1), 5 (CDRL2), and 6 (CDRL3), and wherein said heavy chain variable region has at least 95% sequence identity to the amino acid sequence of SEQ ID No: 9 and wherein said light chain variable region has at least 95% sequence identity to the amino acid sequence of SEQ ID No: 10, wherein said complementarity-determining regions are unchanged.