Patent ID: 6087389
Filing Date: 2000-07-11
Classification: C07C,C07D,C07F

Abstract:
A compound of Formula (I): ##STR20## wherein: R.sub.1 is --X(CH.sub.2).sub.n Ar;dihydrobenzofuranyl, benzodioxanyl, cyclohexyl orC.sub.1-4 alkyl, wherein Ar is a moiety of formula (a) or (b);R.sub.2 is a moiety of formula (a) or (b);P.sub.1 is --X(CH.sub.2).sub.n R.sub.8 ;P.sub.2 is hydrogen or C.sub.1-4 alkyl;R.sub.6 is independently hydrogen or C.sub.1-4 alkyl;R.sub.7 is independently hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl or C.sub.2-8 alkynyl, all of which may be unsubstituted or substituted by one or more OH, N(R.sub.6).sub.2, CO.sub.2 R.sub.12, Br, Cl, F, I, or XC.sub.1-5 alkyl; or R.sub.7 is (CH.sub.2).sub.n Ar;R.sub.8 CONR.sub.7 SO.sub.2 R.sub.11 is or CN;R.sub.9 is a bond, C.sub.1-10 alkylene, C.sub.2-10 alkenylene, C.sub.1-10 alkylidene, C.sub.2-10 alkynylene, all of which may be linear or branched, or R.sub.9 is phenylene, all of which may be unsubstituted or substituted by one or more OH, N(R.sub.6).sub.2, COOH or halogen;R.sub.10 is hydrogen;R.sub.11 is hydrogen, Ar, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, all of which may be unsubstituted or substituted by one or more OH, CH.sub.2 OH, N(R.sub.6).sub.2 Br, Cl, I, or F;R.sub.12 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-7 alkynyl;R.sub.13 is divalent Ar, C.sub.1-10 alkylene, C.sub.1-10 alkylidene, C.sub.2-10 alkenylene, C.sub.2-10 alkynylene, all of which may be unsubstituted or substituted by one or two OH, CH.sub.2 OH, N(R.sub.6).sub.2 Br, Cl, I, or F;X is (CH.sub.2).sub.n or O;Y is CH.sub.3 or X(CH.sub.2).sub.n Ar;Ar is: ##STR21## A is CH.sub.2 ; B is --O--;Z.sub.1, Z.sub.2 and Z.sub.3 are independently hydrogen, OH, C.sub.1-8 alkoxy, S(O).sub.q C.sub.1-8 alkyl, N(R.sub.6).sub.2, Br, F, I, Cl, NHCOR.sub.6, --X--R.sub.9 --Y, --X(CH.sub.2).sub.n R.sub.8 ; or Z.sub.1 and Z.sub.2 together may be --O--A--O-- on contiguous carbons;q is zero, one or two;n is an integer from 0 to six;m is 1, 2 or 3 or a pharmaceutically acceptable salt thereof; provided that when Z.sub.1, Z.sub.2, or Z.sub.3 is X(CH.sub.2).sub.n R.sub.8 and n is not 0, X is oxygen or when R.sub.8 is OR.sub.6 or CO.sub.2 H; and further provided P.sub.1 is not CO.sub.2 H, C(R.sub.6).sub.2 COOH or tetrazole when P.sub.2 is hydrogen.