Patent ID: 7691977
Filing Date: 2010-04-06
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody, or an Fab fragment thereof, capable of binding to mouse VEGF and human VEGF with Kd values within 10 fold of the other, wherein the antibody is capable of inhibiting the binding of VEGF to a VEGF receptor and wherein the antibody comprises a CDR-H1 comprising the amino acid sequence ASWIH (SEQ ID NO: 936), a CDR-H2 comprising the amino acid sequence AIYPYSGYTNYADSVKG (SEQ ID NO: 940), a CDR-H3 comprising the amino acid sequence WGHSTSPWAMDY (SEQ ID NO: 932), a CDR-L1 comprising the amino acid sequence RASQDVSTAVA (SEQ ID NO: 85), a CDR-L2 comprising the amino acid sequence SASFLYS (SEQ ID NO: 86), and a CDR-L3 comprising the amino acid sequence QQSYTTPPT (SEQ ID NO: 87).