Patent ID: 6168912
Filing Date: 2001-01-02
Classification: C07C,C07D,C40B

Abstract:
A method of making a combinatorial chemical library, comprising the step of: converting in parallel a set of at least two different .alpha.-allyl carbonyl monomers to form monomer derivatives, the monomers having a structure R.sup.1 R.sup.2 C(CR.sup.4 R.sup.5 --CR.sup.6.dbd.CR.sup.7 R.sup.8)--COR.sup.3 wherein R.sup.1 and R.sup.2 are independently H, alkyl, aryl, carbocyclic, heterocyclic, or chemical moieties comprising one or more atoms of O, N, S, X, or P, wherein X is halogen; COR.sup.3 is an amide, an ester, or a carboxyl group; and R.sup.4 -R.sup.8 are independently H, aryl, or alkyl; wherein the step of converting comprises converting the allyl functionality --(CR.sup.4 R.sup.5 --CR.sup.6.dbd.CR.sup.7 R.sup.8) of the monomers to a structurally distinct functionality such that the set of monomers having converted allyl functionalities form a combinatorial chemical library, said method further comprising the step of covalently linking at least two monomers to form oligomers, wherein the monomers are selected from the group consisting of the at least two different .alpha.-allyl carbonyl monomers and the monomer derivatives thereof wherein the said oligomers contain at least two monomers linked through an heteroatom.