Patent ID: 7217718
Filing Date: 2007-05-15
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting rejection of a transplanted organ, tissue or cell in a recipient mammal, the method comprising the step of administering to the recipient mammal an effective amount of anti-CD40L monoclonal antibody or rapamycin and an effective amount of a compound represented by the following structural formula: or a physiological salt thereof, wherein: R R R R R wherein each substituted aryl group, substituted alkyl group or substituted aralkyl group are independently optionally substituted at a carbon atom with —OH, —Br, —Cl, —I, —F, R, —CH wherein each substituted aryl group or substituted aralkyl group are independently optionally substituted at a nitrogen atom, if present, with —R′, —N(R′) R′ is hydrogen, an alkyl group, phenyl, —O(Ph), CH each R is independently an alkyl, benzyl, or aryl group; or —N(R) k is 0, 1 or 2.