Patent ID: 9072790
Filing Date: 2015-07-07
Classification: A61K,A61P,C07H

Abstract:
1. A method of inhibiting tumor cell growth comprising: contacting a tumor cell that expresses telomerase with a compound comprising an oligonucleotide conjugated to a nucleobase, having the structure: wherein A is a single nucleobase, n=1 or 2, and L is a flexible linker group, such that A-L does not represent a nucleoside or nucleotide, and L does not include a 5- or 6-membered closed ring sugar group; O is an oligonucleotide consisting of 4 to 15 nucleoside subunits joined by N3′→P5′ phosphoramidate or N3′→P5′ thiophosphoramidate intersubunit linkages and comprising a sequence of 4 or more consecutive nucleosides exactly complementary to the template region of human telomerase RNA; and wherein the tumor cell growth is inhibited.