Patent ID: 6548504
Filing Date: 2003-04-15
Classification: A61P,C07D

Abstract:
A compound of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C) below: in whichP is a monocyclic alicyclic ring containing 4-10 carbon atoms; A is a single bond, a C1-6alkylene or a C2-6alkenylene group; R1 is halogen, C1-6alkyl optionally substituted by one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, amino, alkylamino or dialkylamino, SR11 where R11 is hydrogen or C1-6alkyl or R1 is aryl, or arylC1-6alkyl; n is 0, 1, 2 or 3; and R2 is hydrogen, C1-6alkyl, aryl, arylC1-6alkyl or C3-6cycloalkyl; or in which Ra is an alkyl group containing 1 to 20 carbon atoms or is an arylC1-6alkyl group, and Rb is hydrogen; or in which Q is a monocyclic group containing a nitrogen heteroatom bonded to the adjacent SO2 group or Q is a 5 or 6-membered heterocyclic ring containing a nitrogen heteroatom bonded to the adjacent SO2 group and a further heteroatom selected from nitrogen, oxygen or sulphur, and R1 and n are as defined above; R3 is a group R5; R4 is a piperazine ring optionally substituted by C1-6 alkyl; R5 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy optionally substituted with one or more fluorine atoms, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl or trifluoromethyl.