Patent ID: 6716836
Filing Date: 2004-04-06
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinA is a connecting chain of (C1-3) alkyl; B is O or S; R1 is H, (C1-6) alkyl, halo, CF3, or OR1a wherein R1a is H or (C1-6)alkyl; R2 is H or Me; R3 is H or Me; R4 is selected from the group consisting of: H, (C1-4)alkyl, (C3-4) cycloalkyl and (C1-4)alkyl-(C3-7)cycloalkyl; W is selected from â€ƒwherein, a) one of Y is SO2 and the other Y is NR5, provided that both are not the same, wherein R5 is selected from the group consisting of: H, (C1-6)alkyl, (C3-6) cycloalkyl, said alkyl being optionally substituted with a substituent selected from the group consisting of: (i) (C3-6 cycloalkyl); (ii) 5- or 6-membered heterocycle having 1 to 4 heteroatoms selected from O, N, and S, said heterocycle being optionally substituted with (C1-6)alkyl; (iii) NR5aR5b, wherein each of R5a and R5b is H or (C1-6)alkyl said alkyl being optionally substituted with (C1-6)alkoxy, (C6-10)aryl or 5- or 6-membered heterocycle having 1 to 4 heteroatom selected from O, N, and S, said heterocycle being optionally mono- or di-substituted with (C1-6)alkyl; (iv) OR5c wherein R5c is H, (C1-6) alkyl or 5- or 6-membered heterocycle having 1 to 4 heteroatoms selected from O, N, and S; (v) OCONR5dR5e, wherein R5d and R5e are both H; or R5d is H and R5e is (C1-6)alkyl; (vi) COOR5f, wherein R5f is H or (C1-6)alkyl; (vii) CONR5gR5h wherein each of R5g and R5h is H or (C1-6)alkyl; or R5g is H and R5h is (C3-7)cycloalkyl, said alkyl and said cycloalkyl being optionally substituted with COOR5i wherein R5i is selected from the group consisting of: H and (C1-6)alkyl; or CONHNH2; or OH or (C1-6)alkoxy; or (C6-10)aryl; or 5- or 6-membered heterocycle having 1 to 4 heteroatom selected from O, N, and S, said heterocycle being optionally mono- or di-substituted with (C1-6)alkyl; or R5h is NR5jR5k wherein when R5j and R5k are both H; or R5j is H and R5k is CH2CF3; or R5h is 5- or 6-membered heterocycle having 1 to 4 heteroatoms selected from O, N, and S; (viii) COR5l wherein R5l is (C1-6) alkyl or 5- or 6-membered heterocycle having 1 to 4 heteroatoms selected from O, N, and S, said heterocycle being optionally substituted with (C1-6)alkyl; (ix) SO2R5m, wherein R5m is (C1-6)alkyl or NH2; and (x) SO3H, or R5 is COR5n wherein R5n is (C1-6) alkyl or 5- or 6-membered heterocycle having 1 to 4 heteroatoms selected from O, N, and S, said heterocycle being optionally substituted with (C1-6)alkyl; COOR5o wherein R5o is (C1-6) alkyl; CONR5pR5q wherein each of R5p and R5q is H, OH, (C1-6)alkoxy, or (C1-6)alkyl said alkyl being optionally substituted with (C1-6)alkoxy, (C6-10)aryl, 5- or 6-membered heterocycle having 1 to 4 heteroatom selected from O, N, and S, said heterocycle being optionally mono- or di-substituted with (C1-6)alkyl; and COCH2NR5rR5s wherein each of R5r and R5s is H or (C1-6)alkyl, said alkyl being optionally substituted with (C1-6)alkoxy, (C6-10)aryl, or 5- or 6-membered heterocycle having 1 to 4 heteroatom selected from O, N, and S, said heterocycle being optionally mono- or di-substituted with (C1-6)alkyl; and each R8 is independently H, (C1-4) alkyl, (C3-6) cycloalkyl, or (C1-4) alkyl-(C3-6) cycloalkyl; or b) E is CR8aR8b wherein each of R8a and R8b is H, (C1-4) alkyl, (C3-6) cycloalkyl, or (C1-4) alkyl-(C3-6) cycloalkyl, and J is CH2; or J is CR8aR8b wherein R8a and R8b are as defined above and E is CH2, wherein the dotted line represents a single bond; or c) E is C(O) and J is OR8aR8b wherein R8a and R8b are as defined above; or J is C(O) and E is CR8aR8b wherein R8a and R8b are as defined above, wherein the dotted line represents a single bond; or d) both E and J are CR8 wherein R8 is as defined above, wherein the dotted line represents a double bond; or a salt or a prodrug thereof.