Patent ID: 6512140
Filing Date: 2003-01-28
Classification: C07C,C07D

Abstract:
A process for preparing 1-(mercaptomethyl)-cyclopropaneacetic acid, comprising:(a) converting 1-(hydroxymethyl)-cyclopropaneacetonitrile to 5-oxa-spiro[2.4]hept-6-ylideneamine, an acid addition salt thereof, and/or 1-(halomethyl)-cyclopropaneacetamide by treatment of said 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid; (b) reaction of said 5-oxa-spiro[2.4]hept-6-ylideneamine, said acid addition salt thereof, and/or said 1-(halomethyl)-cyclopropaneacetamide with thiourea to produce 1-(carbamimidoylsulfanylmethyl)-cyclopropaneacetamide or an acid addition salt thereof; (c) converting said 1-(carbamimidoylsulfanylmethyl)-cyclopropaneacetamide to 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide by hydrolysis of said 1-(carbamimidoylsulfanylmethyl)-cyclopropaneacetamide, followed by oxidation to produce said disulfide; and (d) reduction of said disulfide to produce said 1-(mercaptomethyl)-cyclopropaneacetic acid.