Patent ID: 6391881
Filing Date: 2002-05-21
Classification: C07D

Abstract:
A compound of Formula I and its pharmaceutically acceptable acid addition salts or hydrates thereof whereinR1 and R4 are independently selected from lower alkyl and CO2R6 where R6 is lower alkyl; R2 and R3 are independently selected from lower alkyl; R5 is hydrogen or halogen; n is an integer selected from 1 to 5: Z is where X is CH or N;is R9 is hydrogen, lower alkyl, â€”CO2R6, (CH2)mR10, hydroxy, cyano, and â€”(CH2)mNR11R12; R10 is selected from C3-7 cycloalkyl, naphthyl and R13 is selected from hydrogen, lower alkyl, lower alkenyl, C3-7 cycloalkyl, lower alkoxy, hydroxy, dialkylamino, phenoxy, amino, NRCOR6, CO2R6, NO2, trifluoromethyl, and phenyl; m is zero or an integer of 1 to 3; R11 and R12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, phenyl alkylamino, methoxy, cyano, naphthyl, furfuryl, and tetrahydrofurfuryl.