Patent ID: 8222378
Filing Date: 2012-07-17
Classification: A61K,A61P,C07K

Abstract:
1. An isolated neurotrophic growth factor polypeptide with neurotrophic activity comprising: (a) seven conserved cysteine residues at positions 16, 43, 47, 80, 81, 109, and 111 when the seven cysteine residues are aligned with the seven cysteines within SEQ. ID. NO.3; (b) amino acid residues as follows: C at position 16, L at position 18, V at position 25, L at position 28, G at position 29, L at position 30, G at position 31, E at position 36, F at position 40, R at position 41, F at position 42, C at position 43, G at position 45, C at position 47, C at position 80, C at position 81, R at position 82, P at position 83, F at position 91, D at position 93, S at position 105, A at position 106, C at position 109 and C at position 111, each when numbered in alignment with SEQ. ID. NO.3; (c) an LGLG repeat, an FRFC motif, a QPCCRP motif, and a SATACGC motif; and (d) wherein the isolated neurotrophic growth factor polypeptide comprises at least 90% amino acid homology to residues 1-113 of SEQ. ID. NO. 3, and wherein the isolated neurotrophic growth factor polypeptide has neurotrophic activity.