Patent ID: 6471994
Filing Date: 2002-10-29
Classification: A61K,Y10S

Abstract:
A method for preparing a pharmaceutical excipient, comprising:forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and silicon dioxide having a surface area from about 10 m2/g to about 500 m2/g, wherein said slurry comprises from about 0.5% to about 25% by weight microcrystalline cellulose in the form of a wet cake; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose and said silicon dioxide, the amount of silicon dioxide being from about 0.1% to about 20% relative to the amount of microcrystalline cellulose, by weight.