Patent ID: 8017574
Filing Date: 2011-09-13
Classification: A61P,G01N

Abstract:
1. A method of preparing a pharmaceutical composition comprising a G protein-coupled receptor 119 (GPR119) agonist having the effect of a glucose-dependent insulinotropic peptide (GIP) secretagogue, the method comprising: (a) contacting, in vitro, the GPR119 agonist with a vertebrate enteroendocrine cell or with a cell capable of secreting GIP, (b) determining whether the GPR119 agonist stimulates GIP secretion from the vertebrate enteroendocrine cell or from the cell capable of secreting GIP; wherein the ability of the GP119 agonist to stimulate GIP secretion from the vertebrate enteroendocrine cell or from the cell capable of secreting GIP is indicative of the agonist being a GIP secretagogue; and (c) formulating the GPR119 agonist having the effect of a GIP secretagogue with a pharmaceutically acceptable carrier.