Patent ID: 6403584
Filing Date: 2002-06-11
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof wherein:X is 1) â€”Sâ€”, 2) â€”S(O)mâ€”, Y is 1) a bond, or 2) â€”C(R7)(R8)â€”m is an integer from 1 to 2; n is an integer from 1 to 10; p is a number chosen from 0, 1, 2, or 3; R1 is 1) hydrogen, provided X is S, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl, 5) Cy, or 9) â€”NRdRe, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from Ra, and Cy is optionally substituted with one to four substituents independently selected from Rb; R2 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, and 4) C2-10alkynyl, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from Ra; R3 is 1) C1-10alkyl, 2) Ar1, 3) Ar1-C1-10alkyl, 4) Ar1â€”Ar2, 5) Ar1â€”Ar2-C1-10alkyl, wherein the alkyl group is optionally substituted with one to four substituents selected from Ra, and Ar1 and Ar2 are optionally substituted with one to four substituents independently selected from Rb, R4 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from Ra; R5 is 1) hydroxy, 2) C1-10alkoxy, 3) C2-10alkenyloxy, 4) C2-10alkynyloxy, 5) Cyâ€”Oâ€”, 6) Cy-C1-10alkoxy, 7) amino, 8) C1-10alkylamino, 9) di(C1-10alkyl)amino, 10) Cy-C1-10alkylamino, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from Ra, and Cy is optionally substituted with one to four substituents independently selected from Rb; R6 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl, 5) Cy 6) â€”S(O)mRd, 7) â€”S(O)mNRdRe, 8) â€”C(O)Rd, 9) â€”CO2Rd, 10) â€”CO2(CRfRg)nCONRdRe, or 11) â€”C(O)NRdRe, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from Ra, and Cy is optionally substituted with one to four substituents indepdently selected from Rb; or R6 and an Rh attached to the carbon atom adjacent to the ring nitrogen together complete a 4-8 membered ring optionally containing one other heteroatom chosen from nitrogen, oxygen and sulfur; R7 is 1) hydrogen, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 5) Ar1, 6) Ar1-C1-10alkyl, 7) â€”ORd, 8) â€”O(CRfRg)nNRdRe, 9) â€”OC(O)Rd, 10) â€”OC(O)NRdRe, 11) halogen, 12) â€”SRd, 13) â€”S(O)mRd, 14) â€”S(O)2ORd, 15) â€”S(O)mNRdRe, 16) â€”NO2, 17) â€”NRdRe, 18) â€”NRdC(O)Re, 19) â€”NRdS(O)mRe, 20) â€”NRdC(O)ORe, or 21) â€”NRdC(O)NRdRe, wherein alkyl, alkenyl, alkynyl and Ar1 are optionally substituted with one to four substituents selected from a group independently selected from Rc; R8 is 1) hydrogen, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 5) Cy, or 6) Ar1-C1-10alkyl, wherein alkyl, alkenyl, alkynyl, Cy and Ar1 are optionally substituted with one to four substituents selected from a group independently selected from Rc; Ra is 1) halogen, 2) â€”ORd, 3) â€”OC(O)Rd, 4) â€”OC(O)NRdRe, 5) â€”O(CRfRg)nNRdRe, 6) â€”SRd, 7) â€”S(O)mRd, 8) â€”S(O)2ORd, 9) â€”S(O)mNRdRe, 10) â€”NRdRe, 11) â€”NRdC(O)Re, 12) â€”NRdC(O)ORe, 13) â€”NRdC(O)NRdRe, 14) â€”C(O)Rd, 15) â€”CO2Rd, 16) â€”C(O)NRdRe, 17) â€”CO2(CRfRg)nCONRdRe, 18) â€”CN, 19) â€”CRd(Nâ€”ORe), 20) â€”NO2, 21) CF3, 22) â€”OCF3, or 23) Cy optionally substituted with one to four substituents independently selected from Rc; Rb is 1) a group selected from Ra, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, or 8) Ar1-C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Ar1 are optionally substituted with one to four substituents selected from a group independently selected from Rc; Rc is 1) halogen, 2) amino, 3) C1-4alkylamino, 4) di(C1-4alkyl)amino 5) carboxy, 6) cyano, 7) C1-4alkyl, 8) arylC1-4alkyl, 9) Ar1, 10) hydroxy, 11) C1-4alkoxy, 12) aryloxy, or 13) CF3; Rd and Re are independently selected from hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, Cy and Cy C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Cy are optionally substituted with one to four substituents independently selected from Rc; or Rdand Re together with the atoms to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen; Rf and Rg are independently selected from hydrogen, C1-10alkyl, Cy and Cy-C1-10alkyl; or Rf and Rg together with the carbon to which they are attached form a ring of 4 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen; Rh is 1) a group selected from Ra, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 5) Cy, 6) oxo, wherein alkyl alkenyl, alkynyl, and Cy are optionally substituted with one to four substituents selected from a group independently selected from Rc; or two Rh groups attached to adjacent ring atoms together complete 4-8 membered aromatic or non-aromatic ring containing 0-2 heteroatom selected from oxygen, sulfur and nitrogen; or two Rh groups attached to the same ring atom together complete a 4-8 membered ring containing 0-2 heteroatom selected from oxygen, sulfur and nitrogen; with the proviso that when Rh is chosen from 1) â€”ORd, 2) â€”OC(O)Rd, 3) â€”OC(O)NRdRe, 4) â€”O(CRfRg)nNRdRe, 5) â€”SRd, 6) â€”S(O)mRd, 7) â€”S(O)2ORd, 8) â€”S(O)mNRdRe, 9) â€”NRdRe, 10) â€”NRdC(O)Re, 11) â€”NRdC(O)ORe, 12) â€”NRdC(O)NRdRe, or 13) â€”NO2, 14) halogen, 15) â€”CN, and 16) â€”CRd(Nâ€”ORe), â€ƒit is not attached to an atom adjacent to the ring nitrogen; Cy is cycloalkyl, heterocyclyl, aryl or heteroaryl; Ar1 and Ar2 are independently selected from aryl and heteroaryl.