Patent ID: 6319930
Filing Date: 2001-11-20
Classification: A61P,C07C,C07D

Abstract:
A compound selected from those of formula (I):A--G.sub.1 --Cy--G.sub.2 --Cy--G.sub.3 --B (I)wherein:A represents a grouping of formula ##STR12##wherein:Q represents sulphur or oxygen,R.sup.1, R.sup.2 and R.sup.3, which may be identical or different, represent hydrogen or R.sub.a (wherein R.sub.a represents unsubstituted or substituted linear or branched (C.sub.1 -C.sub.6)alkyl, unsubstituted or substituted linear or branched (C.sub.2 -C.sub.6)alkenyl, unsubstituted or substituted linear or branched (C.sub.2 -C.sub.6)alkynyl, unsubstituted or substituted (C.sub.3 -C.sub.8)-cycloalkyl, unsubstituted or substituted cycloalkyl-(C.sub.3 -C.sub.8)alkyl (C.sub.1 -C.sub.6) in which the alkyl moiety is linear or branched, polyhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, aryl, aryl(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, aryl(C.sub.2 -C.sub.6)alkenyl in which the alkenyl moiety is linear or branched, heteroaryl, heteroaryl(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, or heteroaryl(C.sub.2 -C.sub.6)alkenyl in which the alkenyl moiety is linear or branched),or R.sup.2 and R.sup.3 form, with the nitrogen atom carrying them, a group selected from piperazinyl, piperidinyl, and pyrrolidinyl,B represents a grouping of formula ##STR13## ##STR14##or--NR.sup.2 R.sup.3, wherein Q, R.sup.1, R.sup.2 and R.sup.3 are as defined hereinbefore,G.sub.1 and G.sub.3, which may be identical or different, represent a linear or branched alkylene chain having 1 to 4 carbon atoms that is optionally substituted by one or more identical or different groups selected from hydroxy, carboxy, formyl, R.sub.a, OR.sub.a, COOR.sub.a and COR.sub.a (wherein R.sub.a is as defined hereinbefore),Cy representsa ring structure of formula (II): ##STR15##wherein:X and Y, which may be identical or different, represent sulphur, oxygen, carbon, or CH, or CH.sub.2,R.sup.4 represents hydrogen, halogen, CF.sub.3, hydroxy, carboxy, formyl, amino, NHR.sub.a, NR.sub.a R.sup.1.sub.a, NHCOR.sub.a, CONHR.sub.a, R.sub.a, OR.sub.a, COR.sub.a, or COOR.sub.a (wherein R.sub.a is as defined hereinbefore and R.sup.1.sub.a can have any of the meanings of R.sub.a),the symbol -- -- -- -- means that the bonds are single or double, with the proviso that the valency of the atoms is respected,wherein G.sub.2 substitutes the benzene ring, and G.sub.1 (and G.sub.3 respectively) substitutes the ring containing X and Y,or Cy represents a ring structure of formula (III): ##STR16##wherein:Z represents sulphur, oxygen, CH, CH.sub.2, NH, NSO.sub.2 Ph, or NR.sub.a (wherein R.sub.a is as defined hereinbefore),D represents a benzene or pyridine ring,R.sup.4 is as defined hereinbefore,the symbol -- -- -- -- means that the bond is single or double, with the proviso that the valency of the atoms is respected,wherein G.sub.2 substitutes the D ring, and G.sub.1 (and G.sub.3 respectively) substitutes the ring containing Z,it being understood that the two rings (Cy) of the compounds of formula (I) represent the same basic ring structure (indole/indole, naphthalene/naphthalene, benzofuran/benzofuran, etc.), but that the substituent R.sup.4 may be different,G.sub.2 represents a chain of formula (IV): ##STR17##wherein:W.sub.1, W.sub.2 and W.sub.3, which may be identical or different, represent a bond, oxygen, sulphur, CH.sub.2, CHR.sub.a, NH, or NR.sub.a (wherein R.sub.a is as defined hereinbefore),n represents 0.ltoreq.n.ltoreq.6,m represents 0.ltoreq.m.ltoreq.6,with the proviso that it is not possible to have two consecutive hetero atoms and that the chain of formula (IV) so defined may have one or more unsaturated bonds,wherein:the compound of formula (I) cannot represent diethyl 2-(acetylamino)-2-{[5-({3-[2-(acetylamino)-3-ethoxy-2-(ethoxycarbonyl)-3-o xopropyl]-1H-indol-5-yl}methyl)-1H-indol-3-yl]methyl}malonate,or N-{2-[5-({3-[2-(acetylamino)ethyl]-1H-indol-5-yl}methyl)-1H-indol-3-yl]-me thyl}acetamide,""aryl"" is understood to mean naphthyl, phenyl, or biphenyl,""heteroaryl"" is understood to mean any saturated or unsaturated mono- or bi-cyclic group containing 5 to 10 atoms and containing 1 to 3 hetero atoms selected from nitrogen, sulphur, and oxygen,it being possible for ""aryl"" and ""heteroaryl"" to be substituted by one or more identical or different radicals selected from hydroxy, carboxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, linear or branched (C.sub.1 -C.sub.6)alkyl, polyhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, formyl, cyano, nitro, amino, linear or branched (C.sub.1 -C.sub.6)alkylamino, di-(C.sub.1 -C.sub.6)alkylamino in which each alkyl moiety is linear or branched, and halogen,the term ""substituted"" applied to the terms ""alkyl"", ""alkenyl"", and ""alkynyl"" means that those groups are substituted by one or more identical or differentradicals selected from hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, polyhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C.sub.1 -C.sub.6)alkylamino, di-(C.sub.1 -C.sub.6)alkylamino in which each alkyl moiety is linear or branched, and halogen,the term ""substituted"" applied to the terms ""cycloalkyl"" and ""cycloalkylalkyl"" means that the cyclic moiety of those groups is substituted by one or more identical or different radicals selected from hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy, polyhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C.sub.1 -C.sub.6)alkylamino, di-(C.sub.1 -C.sub.6)alkylamino in which each alkyl moiety is linear or branched, and halogen,its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically/acceptable acid or base.