Patent ID: 6432944
Filing Date: 2002-08-13
Classification: A61K,C07K

Abstract:
A compound of Formula I or its stereoisomers, pharmaceutically acceptable salts or hydrates thereof whereinR1 is hydrogen, hydroxyl, or oxo; R2 is C1-6 alkyl, C2-6 alkenyl or alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, heteroaryl, â€ƒwith aryl being phenyl or naphthyl, and heteroaryl being furanyl, thienyl, or pyridinyl; R3 and R4 are independently selected from C1-6 alkyl; R5 and R6 are independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl or alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, â€ƒand â€”CO2R10; R7 is hydrogen or can be taken with R6 as &boxH;O; R8 and R9 are independently selected from hydrogen, halogen, trifluoromethyl, C1-6 alkyl or alkoxy; R10 is C1-6 alkyl; n is zero or one; m is one or two; p is zero, one or two; and the solid and dotted lines are either a single or a double covalent bond with the proviso that when they represent a double bond in the benzodiazepinone ring, n is zero.