Patent ID: 6191292
Filing Date: 2001-02-20
Classification: C07C,C07F

Abstract:
A method of preparing a compound of formula (I): ##STR14##in which:A is a group --CH.sub.2 OH, --CH.sub.2 --OCOR', --COR"", --CSR"" or an ethynyl;R is hydrogen or a (C.sub.1 -C.sub.6)alkyl;R.sub.1 is hydrogen, a (C.sub.1 -C.sub.6)alkyl or a group --(CH2).sub.n --OP;R.sub.2 is hydrogen or a group --OP;R' is a (C.sub.1 -C.sub.6)alkyl or a phenyl;R"" is hydrogen, a hydroxyl, a (C.sub.1 -C.sub.6)alkyl, a (C.sub.1 -C.sub.6)alkoxy, a (C.sub.1 -C.sub.6)alkylthio, or a di(C.sub.1 -C.sub.3)alkylamino;P is hydrogen; a (C.sub.1 -C.sub.6)alkanoyl; a benzoyl in which the phenyl is optionally substituted by a (C.sub.1 -C.sub.4)alkyl, a halogen or a nitro; a (C.sub.1 -C.sub.6)alkoxycarbonyl; a group --Si(R.sub.3).sub.3 in which each R.sub.3 independently represents a (C.sub.1 -C.sub.6)alkyl or a phenyl; a mono- or di-(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl; a tetrahydrofuranyl; or a tetrahydropyranyl;n is 0, 1, 2, 3 or 4,which method comprises the steps of(i) reacting a compound of formula 1 ##STR15##in which A is a (C.sub.1 -C.sub.6)alkoxycarbonyl or a di(C.sub.1 -C.sub.3)alkylaminocarbonyl and R is as defined above, with a lipase in a vinylalkanoate or an acid anhydride, and(ii) converting the resulting compound of formula 2 or 2' ##STR16##in which Z is an alkyl, to the corresponding compound of formula (I).