Patent ID: 7989481
Filing Date: 2011-08-02
Classification: A61P,C07C,C07D

Abstract:
1. A method of inhibiting one or more of NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.5, NaV1.6, NaV1.7, NaV1.8, NaV1.9, or CaV2.2 activity in: (a) a patient; or (b) a biological sample; comprising administering to said patient, or contacting said biological sample with a compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: ring Z is a 5-7 membered unsaturated or aromatic ring having at least one ring heteroatom selected from O, S, N, or NH, wherein and said ring Z is optionally substituted with z occurrence of R z is 0-4; R X is a bond, 0, NR Q is a bond or a C1-C6 straight or branched alkylidine chain, wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR R wherein R R R n is 0, 1 or 2; Y is halo, CN, NO two R R R R R R R Z′ is selected from halo, CN, NO R (i) when ring Z is an optionally substituted pyrimidin-2-yl, the sulfonyl group is attached at the 5-position and the N(R (ii) when ring Z is an optionally substituted pyrimidin-2-yl, the sulfonyl group is attached at the 5-position and the N(R (iii) when ring Z is an optionally substituted pyrimidin-2-yl, the sulfonyl group is attached at the 5-position and the N(R (iv) when ring Z is an optionally substituted pyrimidin-2-yl, the sulfonyl group is attached at the 5-position and the N(R