Patent ID: 6696474
Filing Date: 2004-02-24
Classification: A61P,C07D

Abstract:
A compound according to formula (I) or a pharmaceutically acceptable salt thereof, wherein:X is (CR1R2)x wherein x is 1, 2, or 3, or X is â€”(CR3R4)â€”CH&boxH;CHâ€”, â€”CH&boxH;CHâ€”(CR3R4)â€”, â€”(CR3R4)â€”Câ‰¡Câ€”, â€”Câ‰¡Câ€”(CR3R4)â€”, wherein R1-R4 are each independently H, OH or (C1-C6) alkoxy, or R3 and R4 taken together are &boxH;O, or R3-R6 are each independently or (C1-C6)alkyl; Y and Z are (CR1R2)n and (CR3R4)m wherein m and n are each independently 0, 1, 2, or 3; B is H or (C1-C6)alkyl; E is COR5, wherein R5 is (C1-C6)alkyl, OH, (C1-C6)alkoxy, NR6R7, wherein R6 and R7 are each independently H or (C1-C6)alkyl, or one of R6 and R7 is H or (C1-C6)alkyl and the other is SO2R8, wherein R8 is H or (C1-C6)alkyl, or E is substituted heteroaryl or R9-R12 are each independently H, halo, aryl, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkanoyl, halo(C1-C6)alkanoyl, benzoyl, or halo(C2-C6)alkanoyl; and one, two, or three of J, K, and L are N, provided that when J, K, or L are N, R9, R10, and R13 are absent at that position.