Patent ID: 7071342
Filing Date: 2006-07-04
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a compound of formula I: comprising: (a) converting the compound of formula II  to a compound of formula IV:  wherein A, in compounds of formulas II and IV, is selected from the group consisting of Br, Cl and I; (b) hydrogenating the compound of formula IV with a suitable hydrogenation catalyst under hydrogen pressure, to form the intermediate compound of formula IV(i): (c) reacting the compound of formula IV(i) with a compound of formula Q:  wherein R represents (C (d) converting the compound of formula III  to a compound of formula VI: (e) adding a protecting group to the compound of formula VI to yield a compound of formula VII:  wherein G represents a protecting group; (f) reacting the compound of formula VII with a suitable organometallic reagent, followed by work-up, to yield a compound of formula VIII: (g) removing the protecting group (G) from the compound of formula VIII to yield a compound of formula IX: (h) converting the compound of formula IX into an imine intermediate compound of formula X: (i) converting the imine intermediate compound of formula X into the salt of formula XI: (j) reacting the compound of formula XI with the compound of formula V to yield the compound of formula I; or (k) converting the compound of formula XI to the free amine:  and reacting the compound of formula XII with the compound of formula V to yield the compound of formula I.