Patent ID: 6132990
Filing Date: 2000-10-17
Classification: A61K,C07K,C12N

Abstract:
A purified and isolated mammalian serine protease inhibitor protein comprising at least 8 cysteine residues and the amino acid sequence:Gln-Cys-R.sub.8 -R.sub.3 -R.sub.9 -Asn-Pro-Pro-Asn-Phe-Cys-Glu-R.sub.4 -AspwhereinR.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of methionine, valine, alanine, phenylalanine, tyrosine, tryptophan, lysine, glycine and arginine; andR.sub.8 and R.sub.9 are the same or different and are selected from the group consisting of methionine, valine, alanine, phenylalanine, tyrosine, tryptophan, lysine, glycine, leucine and arginine, andwherein said protein has less than 107 amino acids and inhibits chymotrypsin and elastase.