Patent ID: 8247558
Filing Date: 2012-08-21
Classification: C07D

Abstract:
1. A process for the preparation of clopidogrel and pharmaceutically acceptable salts thereof comprising: a) contacting methyl alpha-5-4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate with levorotatory camphor-10-sulfonic acid wherein methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)2-chlorophenyl)-acetate and levorotatory camphor-10-sulfonic acid is taken in the mole ratio of at least 1:1.1, b) isolating camphor sulphonate salt of methyl S-(+)-alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate, c) transforming the camphor sulphonate salt of methyl S-(+)-alpha-5-4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)acetate into clopidogrel or pharmaceutically acceptable salts thereof.