Patent ID: 6420410
Filing Date: 2002-07-16
Classification: A61K

Abstract:
A method of treating a mammal having precancerous lesions comprising administering a pharmacologically effective amount of a compound of formula I whereinR1 is selected from a group consisting of lower alkyl, â€”(CR6R7)â€”(CH2)xâ€”C(O)â€”OR4, â€”(CH2)xâ€”C(O)â€”NHR5, or â€”(CH2)xâ€”C(O)â€”NR6R7; R2 is selected from a group consisting of lower alkyl, alkenyl, â€”(CH2)mâ€”R8, substituted or unsubstituted aryl wherein said aryl group is selected from the group consisting of phenyl, benzyl, pyridyl, pyrimidyl, pyrazinyl, piperidyl, imidazolyl, indolyl, triazinyl, tetrazolyl, thiophenyl, furanyl, thiazolyl, pyrazolyl, and pyrrolyl, and wherein said substituents are one to five selected from the group consisting of halogen, lower alkyl, lower alkoxy, amino, nitro, and alkoxycarbonyl; R3 is selected from a group consisting of halogen, lower alkoxy, lower alkyl, benzoyl, nitro, haloalkyl, alkoxycarbonyl, lower alkenoxy, and aryloxy, wherein said aryl group is selected from a group consisting of phenyl and benzyl; R4 is hydrogen or lower alkyl; R5 is selected from a group consisting of hydrogen, lower alkyl, benzyl, pyridyl, pyrimidinyl, pyrazinyl, imidazolyl, indolyl, triazinyl, tetrazolyl, thiophenyl, furanyl, thiazolyl, pyrazolyl, and pyrrolyl; R6 and R7 are independently selected from a group consisting of hydrogen, lower alkyl, tetrahydrofuranyl, tetrahydrofuranyl methyl, â€”(CH2)xâ€”C(O)â€”NH2, â€”(CH2)xâ€”C(O)â€”OR4, lower alkoxy, cyclohexylmethyl, substituted or unsubstituted phenyl, piperidyl, and benzyl, wherein said substituents are one to three selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, and diethylamine; R8 is selected from a group consisting of CN, alkylcarbonyloxy, lower alkylcarbonyl, and arylcarbonyloxy, wherein said aryl is one from a group consisting of phenyl and benzyl; x is 0, 1 or 2; m is 0, 1,2 or 3; and n is 0, 1, or 2.