Patent ID: 6670398
Filing Date: 2003-12-30
Classification: A61K,C07C,C07H

Abstract:
A method for treating transplant rejection in a mammal comprising administering to said mammal an effective amount of a compound of formula or a pharmaceutically acceptable salt thereof wherein:Y is a bond or R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, hydroxy, C1-10alkyl, aryl, heteroaryl, C1-10alkaryl, and aryl C1-10alkyl, wherein all nonhydrogen and hydroxy substituents may optionally be substituted from one or more of the group selected from C1-10alkyl, halogen, nitro, amino, halo1-10alkyl, C1-10alkylamino, diC1-10alkylamino, acyl, and acyloxy; Z is selected from the group consisting of C1-10alkyl, C2-10alkenyl, C2-10alkynyl, hydroxyC1-10alkyl, aryl, heteroaryl, C1-10alkaryl, arylC1-10alkyl, heteroarylC1-10alkyl, C1-10alkoxyC1-10alkyl, C1-10alkylaminoC1-10alkyl, carboxyC1-10alkyl, C1-10dialkylaminoC1-10alkyl, aminoC1-10alkyl, heterocycle, heterocyclC1-10alkyl, R7NH, R7R7N, carboxy, carbohydrate group, carbohydrate lactone group, and an alditol group wherein all may optionally be substituted by one or more R5; R5 is independently selected from the group selected from hydroxy, C1-10alkyl, C1-10alkoxy, halo, nitro, amino, cyano, C1-10alkylamino, diC1-10alkylamino, acyl, acyloxy, COOH, COOR7, OC(O)R7, CH(OH)R7, NHR7, NR7R7, C(O)NH2, C(O)NHR7, CONR7R7, NHC(O)Oâ€”R7, OSO3H, SO3H, SO2NHR7, SO2NR7R7, P(O)(OH)OR7, PO2H2P(O)(OH)R7, P(O)(OR7)2, P(O)R7(OR7), OPO3H, PO3H2, hydroxymethyl, and cyclic phosphate, wherein when possible, all may be optionally substituted by one or more R6; R6 is independently selected from the group consisting of hydroxy, C1-10alkyl, C1-10alkoxy, acyloxy, halo, nitro, amino, cyano, haloC1-10alkyl, C1-10alkylamino, diC1-10alkylamino, acyl, and acyloxy; R7 is independently selected from the group consisting of C1-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxy, C1-10alkoxycarbonylC1-10alkyl, aryl, carboxyC1-10alkyl, C1-10alkylcarboxyC1-10alkyl, C1-10alkylcarboxyC1-10aryl, heterocycle, heterocyclC1-10alkyl, and heteroaryl, wherein all may be optionally substituted by one or more R8; and R8 is independently selected from the group consisting of hydroxy, C1-10alkyl, C1-10alkoxy, acyloxy, halo, nitro, amino, cyano, and carboxy; wherein two R7 groups may come together to form a 4 to 7 membered ring.