Patent ID: 6683090
Filing Date: 2004-01-27
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I, wherein A represents: D represents oxygen, or sulfur; R1 represents hydrogen or methyl; R2 represents hydrogen, or C1-C4alkyl; R3 represents: R4, R5, and R6 are independently at each occurrence selected from hydrogen, halogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, â€”CO2R7, â€”CN, â€”CF3, or Ar, provided that at least one of R4 and R5 is Ar; Ar represents thienyl, furyl, pyridyl or imidazolyl which may optionally be substituted with one or more substituents selected from: hydrogen, halogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, aryl, heteroaryl, â€”CO2R7, â€”CN, â€”NO2, â€”NR8R9, â€”CF3 or â€”OR10; R8, R9, and R10 are independently at each occurrence selected from hydrogen, C1-C4alkyl, aryl, heteroaryl, â€”C(O)R11, â€”C(O)NHR12, â€”C(O)R13 or â€”SO2R14, or R8 and R9 may together be (CH2)jQ(CH2)k where Q is O, S, NR15, or a bond; j is 2to 4; K is 0 to 2; R7, R10, R11, R12, R13, and R15, are independently at each occurrence selected from C1-C4alkyl, aryl, or heteroaryl; or an enantiomer thereof, or a pharmaceutically-acceptable salt thereof;with the proviso that Ar does not represent 2-, 3-, 4-pyridyl, substituted with one or more substituents selected from C1-C4alkyl, C1-C4alkoxy, halogen, phenoxy, hydroxy, OCOR11, NH2, NHCOR11 or nitro, when A represents: R3 represents: D represents oxygen; R represents methyl; R2 and R5 both represent hydrogen and R6 represents any of hydrogen, C1-C4alkyl, phenyl, or cyano.