Patent ID: 8044179
Filing Date: 2011-10-25
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody which specifically binds to an epitope of clusterin located between amino acids 421 and 443 selected from the group consisting of: a) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:8 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:20; b) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:9 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:20, c) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:10 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:21; d) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.11 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO. :22; and e) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:12 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:23.