Patent ID: 6262028
Filing Date: 2001-07-17
Classification: A61K,A61P,C07D,C07K

Abstract:
A compound of formula I,R.sup.1 O(O)C--CH.sub.2 --(R)Cgl--Aze--Pab--R.sup.2 IwhereinR.sup.1 represents --R.sup.3 or --A.sup.1 C(O)N(R.sup.4)R.sup.5 or --A.sup.1 C(O)OR.sup.4 ;A.sup.1 represents C.sub.1-5 alkylene;R.sup.2 (which replaces one of the hydrogen atoms in the amidino unit of Pab--H) represents OH, OC(O)R.sup.6, C(O)OR.sup.7 or C(O)OCH(R.sup.8)OC(O)R.sup.9 ;R.sup.3 represents H, C.sub.1-10 alkyl, or C.sub.1-3 alkylphenyl (which latter group is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro or halogen);R.sup.4 and R.sup.5 independently represent H, C.sub.1-6 alkyl, phenyl, 2-naphthyl or, when R.sup.1 represents --A.sup.1 C(O)N(R.sup.4)R.sup.5, together with the nitrogen atom to which they are attached represent pyrrolidinyl or piperidinyl;R.sup.6 represents C.sub.1-17 alkyl, phenyl or 2-naphthyl (all of which are optionally substituted by C.sub.1-6 alkyl or halogen);R.sup.7 represents 2-naphthyl, phenyl, C.sub.1-3 alkylphenyl (which latter three groups are optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro or halogen), or C.sub.1-12 alkyl (which latter group is optionally substituted by C.sub.1-6 alkoxy, C.sub.1-6 acyloxy or halogen);R.sup.8 represents H or C.sub.1-4 alkyl; andR.sup.9 represents 2-naphthyl, phenyl, C.sub.1-6 alkoxy or C.sub.1-8 alkyl (which latter group is optionally substituted by halogen, C.sub.1-6 alkoxy or C.sub.1-6 acyloxy); provided that when R.sup.1 represents R.sup.3, R.sup.3 represents benzyl, methyl, ethyl, n-butyl or n-hexyl and R.sup.2 represents C(O)OR.sup.7, then R.sup.7 does not represent benzyl;or a pharmaceutically-acceptable salt thereof.