Patent ID: 6656916
Filing Date: 2003-12-02
Classification: A61K,A61P,C12N

Abstract:
A method of increasing the cellular expression of a gene in lung tissue in an animal to treat a pathophysiological state of said animal, comprising the steps of:administering to said animal an aerosolized cationic lipid:vector complex to said lung tissue, said lipid:vector complex adapted to express said gene in said lung tissue, wherein said gene is under control of a promoter that does not have a glucocorticoid response element and wherein expression of said gene treats the pathophysiological state of said animal; and administering to said animal a pharmacologically effective dose of an aerosolized glucocorticoid in an amount sufficient to increase the cellular expression of said gene, wherein the increase in the expression of said gene in said lung tissue enhances the treatment of the pathophysiological state of said animal.