Patent ID: 8871191
Filing Date: 2014-10-28
Classification: A61K,A61P,C07K,C12N,C12P

Abstract:
1. A method of treating lymphopenia in an individual in need thereof comprising systemically administering to the individual a heterodimer comprising (i) an interleukin-15 (IL-15) and (ii) an IL-15Rα-Fc fusion protein that comprises a soluble IL-15Rα fused to an Fc region; wherein the IL-15 has at least 95% amino acid sequence identity to the region of SEQ ID NO:2 that corresponds to mature IL-15; and the IL-15Rα-Fc fusion protein comprises an amino acid sequence that has at least 95% amino acid sequence identity to the IL-15Rα-Fc fusion protein sequence of SEQ ID NO:17 or SEQ ID NO:20; wherein the heterodimer is administered at a dose that maintains supraphysiological plasma levels of IL-15 for two or more days.