Patent ID: 6861512
Filing Date: 2005-03-01
Classification: C07B,C07C,C07H,C40B

Abstract:
1. A process for separating cis and trans isomers in a mixture of geometric isomers of an olefinic compound, the process comprising: (a) flowing a mobile phase through a column means containing a stationary phase comprising an organosilane having a pendant aliphatic functional group attached to a solid support, where R where each J, K and Q, independently, is straight or branched C1 to C15 alkyl; L is O, NH or CH where E is N, O, S, SO, or SO where each U and V, independently, is straight or branched C2 to C15 alkyl and W is hydrogen or straight or branched C1 to C5 alkyl; where Z is straight or branched C1 to C10 alkyl; or pharmaceutically acceptable salts thereof, (b) collecting a first portion of the eluent stream substantially comprising the cis isomer; and (c) collecting a second portion of the effluent stream, substantially comprising the trans isomer.