Patent ID: 7915387
Filing Date: 2011-03-29
Classification: A61K,A61P,C07K

Abstract:
1. An isolated antibody which binds a sialyltetraosyl carbohydrate and directly induces cell death without the need for immune effector cells, wherein the antibody's binding domain comprises a heavy and a light chain and wherein the sequence of CDR1 of the heavy chain is amino acids 44 to 54 or 49 to 54 of SEQ ID NO: 23, the sequence of CDR2 of the heavy chain is amino acids 69 to 84 of SEQ ID NO: 23, the sequence of CDR3 of the heavy chain is amino acids 117 to 127 of SEQ ID NO: 23, the sequence of CDR1 of the light chain is amino acids 46 to 55 of SEQ ID NO: 27, the sequence of CDR2 of the light chain is amino acids 71 to 77 of SEQ ID NO: 27, and the sequence of CDR3 of the light chain is amino acids 110 to 118 of SEQ ID NO: 27.