Patent ID: 8975029
Filing Date: 2015-03-10
Classification: A61K,A61P,C07K

Abstract:
1. An anti-integrin alpha-2 antibody or fragment thereof comprising three heavy chain CDRs, CDR-H1, CDR-H2 and CDR-H3 wherein (a) CDR-H1 is SEQ ID NO: 1, CDR-H2 is SEQ ID NO: 2, and CDR-H3 is SEQ ID NO: 3, (b) CDR-H1 is SEQ ID NO: 7, CDR-H2 is SEQ ID NO: 8, and CDR-H3 is SEQ ID NO: 9, or (c) CDR-H1 is SEQ ID NO: 13, CDR-H2 is SEQ ID NO: 14, and CDR-H3 is SEQ ID NO: 15, and three light chain CDRs, CDR-L1, CDR-L2 and CDR-L3 wherein (a) CDR-L1 is SEQ ID NO: 4, CDR-L2 is SEQ ID NO: 5, and CDR-L3 is SEQ ID NO: 6, (b) CDR-L1 is SEQ ID NO: 10, CDR-L2 is SEQ ID NO: 11, and CDR-L3 is SEQ ID NO: 12, or (c) CDR-L1 is SEQ ID NO: 16, CDR-L2 is SEQ ID NO: 17, and CDR-L3 is SEQ ID NO: 18.