Patent ID: 8933019
Filing Date: 2015-01-13
Classification: A61P,C07K,C12N

Abstract:
1. A method for treatment of human immunodeficiency virus in a subject in need thereof, the method comprising: administering to the subject a composition comprising an isolated peptide comprising a sequence from 14 to 21 amino acids in length, wherein two of the amino acids are unnatural amino acids having either R or S stereochemistry at the α-carbon; wherein the α-carbon of the unnatural amino acids comprises a methyl group and an olefinic group, where the two olefinic groups of the unnatural amino acids are on the same side of the α-helix and are joined to form a cross-link between the two unnatural amino acids; wherein the sequence of the peptide comprises (Q/A)(E/A/K)(V/W)(E/K)NW(M/A)TETLL(V/K)(QAE) (SEQ ID NO:18); wherein the two unnatural amino acids replace two of the amino acids at any positions four amino acids apart (i and 1+4) or seven amino acids apart (i and i+7); and wherein the cross-link between the two unnatural amino acids is a C1-C10 alkyl, alkenyl, alkynyl, (R1-K-R1)