Patent ID: 8076062
Filing Date: 2011-12-13
Classification: C12Q,G01N

Abstract:
1. A method of evaluating the relative effectiveness of drugs against mutant HIV reverse transcriptase comprising at least one mutation T386A, comprising the steps of: (i) providing a HIV reverse transcriptase comprising at least one mutation T386A, said position number is with reference to the HIV strain IIIB/LAI; (ii) determining the activity of said drugs on said mutant HIV reverse transcriptase; (iii) determining the activity of said drugs on a corresponding wild type HIV reverse transcriptase; (iv) determining the ratio of the activity determined in step (iii) over the activity determined in step (ii) for each drug; and (v) evaluating the relative effectiveness of the drugs against said mutant HIV reverse transcriptase based on the ratio of step (iv).