Patent ID: 8674063
Filing Date: 2014-03-18
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A chimerical peptide having a primary structure wherein [P] is a cell penetrating peptide, [L [I] is an NS3pro activation inhibitor sequence which binds with at least one amino acid from the beta strands B2a and B2b of the C-terminal beta barrel or from the beta strand Al of the N-terminal beta barrel of the NS3pro protein from a virus of the Flaviviradae family, [T] is an amino acid sequence between 0-10 residues capable of binding to a P1 and P2 substrate binding sites of the NS3pro protease from a virus of the Flaviviradae family, wherein said chimeric peptide is selected from the group consisting of SEQ ID NOS: 1-62 and 65-364, and wherein said peptide is able to inhibit or attenuate the infection by the virus.