Patent ID: 7803903
Filing Date: 2010-09-28
Classification: A61P,C07H,C07K

Abstract:
1. A doxorubicin-peptide of the formula I wherein Y=O or S n=1 to 5 m=0 to 6 P wherein the peptide sequence can be cleaved by the matrix metalloproteinase 2 and/or 9 (MMP-2 and/or MMP-9) and PM is a protein-binding group which is a maleinimide group, a 2-dithiopyridyl group, a halogen acetamide group, a halogen acetate group, a disulfide group, an acrylic acid ester group, a monoalkylmaleic acid ester group, a monoalkylmaleaminic acid amide group, an isothiocyanate group or an aziridine group, which is optionally substituted and