Patent ID: 7030086
Filing Date: 2006-04-18
Classification: A61K,A61P,Y10S

Abstract:
1. A liquid pharmaceutical composition comprising tissue factor pathway inhibitor (TFPI) or variant thereof as a therapeutically active component, wherein said composition has been prepared by a method comprising the step of combining said TFPI or variant thereof with at least one amino acid and a buffering agent that is an acid substantially free of its salt form, wherein said amino acid is at least one of amino acids arginine in its free base form and lysine in its free base, said composition has a pH within a range of about pH 4.0 to about pH 9.0, and said variant thereof has at least 70% sequence identity with said TFPI as calculated using the ALIGN program with a PAM 120 weight residue table, a gap length penalty of 12, and a gap penalty of 4.