Patent ID: 8258259
Filing Date: 2012-09-04
Classification: A61K,C08G

Abstract:
1. A dendritic motif, comprising at least one subsurface layer of one or more building units and a surface layer of two or more surface building units wherein the surface layer has at least two different functional moieties attached thereto, provided that when there are only two types of functional moiety A and B, the number of functional moieties A does not equal the number of functional moieties B, wherein said functional moieties comprise a first and second functional moiety, each selected from the groups consisting of protecting groups, ligands for extracellular receptors, property modifiers, pharmaceutically active agents or precursors thereof, groups to effect targeting, groups to effect signalling, antigenic material, genetic material and groups to mediate binding to second entity wherein said building units are selected from the group consisting of: Lysine 1: having the structure: Glycyl-Lysine 2 having the structure: Analogue 3, having the structure below, where a is an integer of 1 or 2; b and c are the same or different and are integers of 1 to 4: Analogue 4, having the structure below, where a is an integer of 0 to 2; b and c are the same or different and are integers of 2 to 6: Analogue 5, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5: Analogue 6, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 0 to 5: Analogue 7, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5: and Analogue 9, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5: and said surface building units are selected from the group consisting of: Lysine 1, Glycyl-Lysine 2, Analogues 3, 4, 5, 6, 7 and 9 above, Analogue 10, having the structure below, where a is an integer of 0 to 2; b and c are the same or different and are integers of 1 to 4; A where X is F, Cl, Br or I, Analogue 11, having the structure below, where a is an integer of 0 to 2; b and c are the same or different and are integers of 2 to 6; A Analogue 12, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5; A Analogue 13, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 0 to 5; A Analogue 14, having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5; A and Analogue 16 having the structure below, where a is an integer of 0 to 5; b and c are the same or different and are integers of 1 to 5; A