Patent ID: 6828321
Filing Date: 2004-12-07
Classification: A61K,C07D

Abstract:
A method of selectively killing hypoxic tumor cells sensitive to the compounds of the formula in a host comprising administering to said host an effective amount of a pharmaceutical composition comprising a compound of the formula wherein X is H or hydrocarbyl (1-4C) substituted with OH, NH2, halogen or C1-C4-alkoxy; n is 1; and Y1 and Y2 are independently either H; nitro; halogen; alkoxy (1-6C); hydrocarbyl (1-14C) including cyclic and unsaturated hydrocarbyl, optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, hydroxy, epoxy, alkoxy (1-4C), alkylthio (1-4C), primary amino (NH2), lower alkyl (1-4C) secondary amino, dialkyl (1-4C) tertiary amino, dialkyl (1-4C) tertiary amino where the two alkyls are linked together to produce a morpholino, pyrrolidino or piperidino, acyloxy (1-4C), acylamido (1-4C) and thio analogs thereof, acetylaminoalkyl (1-4C), carboxy, alkoxycabonyl (1-4C), carbamyl, alkylcarbamyl (1-4C), alkylsulfonyl (1-4C) or alkylphosphonyl (1-4C), wherein the hydrocarbyl can optionally be interrupted by a single ether (â€”Oâ€”) linkage; or wherein Y1 and Y2 are independently either morpholino, pyrrolidino, piperidino, NH3, NHRâ€², NRâ€²Râ€² O(CO)Râ€², NH(CO)Râ€², O(SO)Râ€², or O(PORâ€²)Râ€² in which Râ€² is a hydrocarbyl (1-4C) tertiary amino, morpholino, pyrrolidino, piperidino, alkoxy (1-4C), or halogen substitutents, or a pharmacologically acceptable salt of said compound.