Patent ID: 7053105
Filing Date: 2006-05-30
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): or a pharmaceutically acceptable salt or N-oxide or stereochemically isomeric form thereof, wherein r and s are each independently 0, 1, 2, 3, 4 or 5; t is 0, 1, 2 or 3; >Y 1 —Y 2 — is a trivalent radical of formula wherein R p is 0 to 5; R R each R 1 and R 2 are independently azido, hydroxy, halo, cyano, nitro, C 1-4 alkyl, —(CR 20 R 21 ) p —C 3-10 cycloalkyl, cyanoC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, hydroxycarbonylC 1-6 alkyloxyC 1-6 alkyl, R 24 S C 1-6 alkyl, trihalomethyl, arylC 1-6 alkyl, Het 2 C 1-6 alkyl, —C 1-6 alkyl-NR 22 R 23 , —C 1-6 alkylNR 22 C 1-6 alkyl-NR 22 R 23 , —C 1-6 alkylNR 22 COC 1-6 alkyl, —C 1-6 alkylNR 22 COAlkAr 2 , —C 1-6 alkylNR 22 COAr 2 , C 1-6 alkylsulphonylaminoC 1-6 alkyl, C 1-6 alkyloxy, hydroxyC 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyloxy, —OC 1-6 alkyl-NR 22 R 23 , trihalomethoxy, arylC 1-6 alkyloxy, Het 2 C 1-6 alkyloxy, C 1-6 alkylthio, C 2-6 alkenyl, cyanoC 2-6 alkenyl, —C 2-6 alkenyl-NR 22 R 23 , hydroxycarbonylC 2-6 alkenyl, C 1-6 alkyloxycarbonylC 2-6 alkenyl, C 2-6 alkynyl, —CHO, C 1-6 alkylcarbonyl, hydroxyC 1-6 alkylcarbonyl, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, —CONR 22 R 23 , —CONR 22 —C 1-6 alkyl-NR 22 R 23 , —CONR 22 —C 1-6 alkyl-Het 2 , —CONR 22 —C 1-6 alkyl-Ar 2 , —CONR 22 —O—C 1-6 alkyl, —CONR 22 —C 1-6 alkenyl, —NR 22 R 23 , —OC(O)R 24 , —CR 24 ═NR 25 , —CR 24 ═N—OR 25 , —NR 24 C(O)NR 22 R 23 , —NR 24 SO 2 R 25 , —NR 24 C(O)R 25 , —S(O) 0-2 R 24 , a —SO 2 NR 24 R 25 , —C(NR 26 R 27 )═NR 28 ; —Sn(R 24 ) 3 , —SiR 24 R 24 R 25 , —B(OR 24 ) 2 , —P(O)OR 24 OR 25 , aryloxy, Het 2 -oxy, or a group of formula in which R two R 1 and R 2 substituents adjacent to one another on the phenyl ring may independently form together a bivalent radical of formula R R R 3 is hydrogen, halo, cyano, C 1-6 alkyl, —(CR 20 R 21 ) p —C 3-10 cycloalkyl, haloC 1-6 alkyl, cyanoC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, arylC 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkylthioC 1-6 alkyl, hydroxycarbonylC 1-6 alkyl, C 1-6 alkylcarbonylC 1-6 alkyl, C 1-6 alkyloxycarbonylC 1-6 alkyl, C 1-6 alkyl-NR 22 R 23 , C 1-6 alkyl-CONR 22 R 23 , arylC 1-6 alkyl, Het 2 C 1-6 alkyl, C 2-6 alkenyl, —C 2-6 alkenyl NR 22 R 23 , C 2-6 alkynyl, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, aryl, or Het 2 ; or a radical of formula wherein R R R aminocarbonylcarbonyl, mono- or di(C R R R R 4 is a radical of formula wherein R R R R 5 is cyano, hydroxy, halo, C 1-6 alkyl, —(CR 20 R 21 ) p —C 3-10 cycloalkyl , C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkyloxy, arylC 1-6 alkyloxy, Het 2 C 1-6 alkyloxy, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, or a group of formula —NR 22 R 23 or —CONR 22 R 23 ; R 7 is (A) a group selected from: (A1) C (A2) —(CR (A3) C (Aa) halo, cyano, —OR (Ab) —OAlkNR provided that (A) when r and s are each 1, t is 0, R 1 is 3-chloro, R 2 is 4-chloro, R 3 is hydroxy and R 4 is 1-methyl-1H-imidazol-5-yl , and (a) when >Y 1 —Y 2 is a radical of formula (y-2), in which R 9 is hydrogen, then R 7 is not amino, methyl, —CHO or chloro, or (b) when >Y 1 —Y 2 — is a radical of formula (y-1), then R 7 is not chloro; and (B) when >Y 1 —Y 2 is a radical of formula (y-2) and R 4 is a radical of formula (c-1), (c-2) or (c-4) then the group R 7 is (i) a group A1 substituted by substituents (Ab), a group (A2) substituted by substituents (Aa) (other than halo) or (Ab), or a group (A3) optionally substituted by substituents (Aa) or (Ab) as defined above; or (ii) a group (B2) as defined above; or (iii) a group(C1) in which Z is (Cb), or a group (C2) as defined above.