Patent ID: 6214316
Filing Date: 2001-04-10
Classification: A61K,C07K

Abstract:
A somatostatin receptor-binding peptide having a formula:cyclo-A.sup.4 -B.sup.1 B.sup.2 B.sup.3 B.sup.4 -C.sup.4 -whereinB.sup.1 is D- or L-Phe or D- or L-Tyr or D- or L-Nal or Ain;B.sup.2 is D- or L-Trp;B.sup.3 is D- or L-Lys or Hly, Achxa, Amf, Aec, Apc, Aes, or Aps;B.sup.4 is Thr, Ser, Val, Phe, Ile, Abu, Nle, Leu, Nva or Aib;C.sup.4 is an L-amino acid having a sidechain comprising a mercapto group;A.sup.4 is a lipophilic D-amino acid or a lipophilic L-(.alpha.-N-alkyl)amino acid or L-proline;wherein A.sup.4 and C.sup.4 are covalently linked through an amino terminus of A.sup.4 and a carboxyl terminus of C.sup.4.