Patent ID: 6544990
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A compound of formula I or a pharmaceutically acceptable salt thereof whereinX is Cl, Br, CN, NO2, or F; Y is morpholinylmethyl, tetrahydro-2H-pyranylmethyl, hydroxypropynyl, or hydroxypropyl; Z is het1, or Cl-7alkyl optionally substituted with at least one halo, NR1R2, OR3, or het2; R1 and R2 are independently H, Cl-7alkyl, or C2-7alkyl substituted with at least one OH; R3 is H, or C1-7alkyl; het1 is a five-(5), or six-(6) membered saturated or unsaturated heterocyclic ring bonded via a carbon atom having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen, wherein the het is optionally fused to a benzene ring, and optionally substituted with one or more substituents selected from the group consisting of halo, OR3, CN, phenyl, CO2R3, CF3, or C1-6 alkyl which may be further substituted by one to three SR3, NR3R3, OR3, or CO2R3 groups; and het2 is a five-(5), or six-(6) membered saturated or unsaturated heterocyclic ring having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen, wherein het is optionally fused to a benzene ring, and optionally substituted with one or more substituents selected from the group consisting of halo, OR3, CN, phenyl, CO2R3, CF3, oxo, oxime, or C1-6 alkyl which may be further substituted by one to three SR3, NR3R3, OR3, or CO2R3 groups.