Patent ID: 6054590
Filing Date: 2000-04-25
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula I or its pharmaceutically acceptable ##STR77## acid addition salts or hydrates thereof, wherein R.sup.1 is hydrogen or halogen;R.sup.2 is hydrogen, halogen, C.sub.1-6 alkyl, alkoxy, cyano, or trifluoromethyl;R.sup.3 is hydrogen, cyano, or trifluoromethyl;R.sup.4 is hydrogen, halogen, C.sub.1-6 alkyl, formyl, carboxamido, cyano, nitro, or --(CH.sub.2).sub.m --NR.sup.6,R.sup.7 ;R.sup.5 is hydrogen, halogen, C.sub.1-6 alkoxy; with the proviso that R.sup.1 --R.sup.5 cannot all be hydrogen at the same time;R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, C.sub.3-8 cycloalkyl, C.sub.1-4 carbalkoxy, or CO.sub.2 H;R.sup.7 is hydrogen, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, Y-substituted C.sub.1-6 alkyl, Y-substituted C.sub.3-6 alkenyl, ##STR78## or --(CH.sub.2).sub.n --Z; R.sup.8 is hydrogen, halogen, C.sub.1-6 alkyl, alkoxy or nitro;R.sup.9 is hydrogen, halogen, C.sub.1-6 alkyl, alkoxy, alkylcarbonyl, C.sub.3-6 alkenyoxy, di C.sub.1-4 alkylamino, di C.sub.1-4 alkylamino-C.sub.1-6 alkoxy, hydroxy, --O.sub.2 C--C.sub.1-4 alkyl, phenoxy, or trifluoromethyl;m and n are zero or 1;Y is C.sub.3-8 cycloalkyl, cyano, CO.sub.2 H, di C.sub.1-4 alkylamino, hydroxy or ##STR79## R is hydrogen or C.sub.1-4 alkyl; R.sup.10 is hydrogen, hydroxy, or NCO.sub.2 R;R.sup.11 is C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, --CO.sub.2 R, formyl, hydroxy-C.sub.1-6 alkyl, pyridine or R.sup.16 -substituted phenyl;R.sup.12 is hydrogen, C.sub.1-6 alkyl, or cyano;R.sup.13 is hydrogen or phenyl;R.sup.14 is hydrogen or ##STR80## R.sup.15 is hydrogen, halogen, or C.sub.1-4 alkyl; R.sup.16 is C.sub.1-4 alkoxy and nitro; orAr.sup.1 and Ar.sup.2 are independently selected from the group consisting of ##STR81## with R.sup.17 being hydrogen, halogen, C.sub.1-4 alkyl or alkoxy.