Patent ID: 6844154
Filing Date: 2005-01-18
Classification: C12Q

Abstract:
1. A method for haplotyping, comprising: analyzing a first polymorphic locus of a nucleic acid within a sample by specifically capturing the nucleic acid on a surface wherein the step of capturing the nucleic acid on the surface identifies only a first allele of a first SNP of the polymorphic locus, analyzing a second allele of the first SNP of the polymorphic locus by specifically capturing the nucleic acid on a surface wherein the step of capturing the nucleic acid on the surface identifies only the second allele of the first SNP of the polymorphic locus, wherein the nucleic acid is captured by hybridization with an ASO, separately analyzing a second SNP of a polymorphic locus of the captured nucleic acid by hybridization of the nucleic acids with labeled ASOs from solution to identify both alleles of the second SNP, and determining the haplotype based on the identification of each allele of each SNP.