Patent ID: 7297685
Filing Date: 2007-11-20
Classification: A61K,C12N

Abstract:
1. A method of treating, inhibiting, or reducing formation or progression of a vascular lesion caused by aberrant proliferation of neointimal smooth muscle cells in a human patient in need thereof comprising inserting into a neointimal smooth muscle cell in said patient directly at the site of said lesion, or directly at a site where a vascular lesion is likely to develop, a nucleic acid comprising a promoter sequence operably linked to a nucleic acid sequence that encodes a protein comprising a sequence having at least 95% sequence identity to the sequence set forth in SEQ ID NO: 2, wherein said protein is capable of decreasing inflammation or capable of increasing apoptosis of said smooth muscle cell, said inserting being conducted under conditions that result in expression of said protein by said smooth muscle cell, wherein expression of said protein inhibits proliferation of said smooth muscle cell, thereby treating, inhibiting, or reducing formation or progression of said vascular lesion in said patient.