Patent ID: 7064225
Filing Date: 2006-06-20
Classification: B01J,C07C,C07F

Abstract:
1. A method of making a compound of the formula and isomers thereof, comprising: a) contacting a compound of the formula and an alkyl lithium reagent in an ethereal solvent to form a first mixture, wherein the compound of the formula II is substantially deprotonated to form a lithium salt of compound II, Li(II); b) rapidly combining the first mixture with a fulvene compound of the formula to form a second mixture, wherein either the lithium salt of compound II, Li(II), or the compound of the formula III is optionally a limiting reagent, and wherein the limiting reagent, if present, has substantially reacted; and c) contacting the second mixture with a proton source to form a third mixture comprising and isomers thereof; wherein R wherein each R