Patent ID: 7384633
Filing Date: 2008-06-10
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A human anti-human Fcε receptor I (hereinafter referred to as “FcεRI”) antibody or an antibody fragment thereof that binds to a human FcεRI and has an activity to inhibit the binding between the FcεRI and IgE and that is prepared by the genetic recombination technique with an expression vector in which the following gene fragments are incorporated; a) a gene fragment encoding VH chain of the human anti-human FcεRI antibody, wherein complimentary determining regions (CDR1 to CDR3) in said VH chain have the following amino acid sequences; CDR1: Ser Asn Tyr Met Ser (SEQ ID NO: 5); CDR2: Val Ile Tyr Arg Gly Gly Ser Gly Asp Asn Thr Tyr Tyr Ala Gly Ser Val Lys Gly (SEQ ID NO: 6); CDR3: Ser Ser Asp Val Gly Tyr Gly Ile Leu Arg Gly Tyr Met Asp Val (SEQ ID NO: 7), and b) a gene fragment encoding VL chain of the human anti-human FcεRI antibody, wherein complementary determining regions (CDR1 to CDR3) in said VL chain have the following amino acid sequences; CDR1: Ser Gly Gln Asp Leu Thr Asn Lys Tyr Val Ser (SEQ ID NO: 8); CDR2: Glu Asp Ser Lys Arg Pro Ser (SEQ ID NO: 9); CDR3: Gln Ala Tyr Asp Thr Asn Gly Trp Val (SEQ ID NO: 10)