Patent ID: 6018047
Filing Date: 2000-01-25
Classification: C07D,C09K,Y10S

Abstract:
Acridinium compound for use as a chemiluminogenic label, of the formula (1): ##STR1## where A is a divalent organic moiety which may contain one or more heteroatoms and/or carbonyl groups, the nature and length of A being such as to allow the functional group Z to react with a biologically active or a toxicologically active compound;X is a substituent capable of forming a dioxetane with the accridine C-9 atom upon reaction with hydrogen peroxide, wherein X is selected from the group consisting of alkoxycarbonyl and aryloxycarbonyl groups, wherein X does not contain a functional group capable of coupling with a biologically active or a toxicologically active compound;Y is a counter ion; andZ is a functional group capable of coupling with a biologically active or a toxicologically active compound, wherein Z is selected from the group consisting of carboxyl group, a reactive derivative of carboxyl group, isocyanate, isothiocyanate, activated halide, derivatives of sulfonic acid, derivatives of phosphoric acid, azides, protonated carboximidate and amino groups,and wherein the acridinium compound may carry one or more substituents selected from the group consisting of a lower alkyl group, a lower alkoxy group and a halogen at any of positions 1 through 8.