Patent ID: 7172875
Filing Date: 2007-02-06
Classification: G01N

Abstract:
1. A screening method for identifying inhibitors of protein filament formation, comprising: a) providing: b) combining said protein monomer and said fibrillization inducer in one or more control reaction vessels; c) combining said protein monomer, said fibrillization inducer, and said test compound in one or more test reaction vessels; and d) analyzing the contents of the control reaction vessels of step (b) and the test reaction vessels of step (c) for the formation of proteinaceous polymeric filaments, wherein absence or a reduction in the size or stability of proteinaceous polymeric filaments in the test reaction vessels of step (c) as compared to proteinaceous polymeric filaments in the control reaction vessels of step (b) indicates that the test compound is an inhibitor of proteinaceous polymeric filament formation.