Patent ID: 6274606
Filing Date: 2001-08-14
Classification: C07D

Abstract:
A method for providing prevention or treatment of a central nervous system disorder comprising administering to a subject in need thereof, an effective amount of a compound of the formula: ##STR2##wherein X is C--CH.sub.2 --OR' wherein R' is C.sub.1 -C.sub.5 alkyl; E' is hydrogen or C.sub.1 -C.sub.5 alkyl or halo substituted C.sub.1 -C.sub.5 alkyl; E"" is C.sub.1 -C.sub.5 alkyl or halo substituted C.sub.1 -C.sub.5 alkyl; either Z' or Z"" is C.sub.1 -C.sub.7 with the other selected from the group consisting of hydrogen, C.sub.1 -C.sub.5 alkyl, aryl rings, and cycloalkyl; A, A' and A"" are each individually selected from the group consisting of hydrogen, C.sub.1 -C.sub.7 alkyl, and halo; m is 0 or 1; n is 1, 2, 3, 4, 5, 6, 7 or 8; p is 0 or 1 with the proviso that when m or p or both are 0 then E' or E"" is hydrogen; and the wavy line in the structure represents a cis (Z) or trans (E) form of the compound; wherein said compound is administered in an amount effective to prevent or treat said central nervous system disorder.