Patent ID: 6509015
Filing Date: 2003-01-21
Classification: A61K,A61P,C07K,Y02A,Y10S

Abstract:
A method for inhibiting human TNF&agr; activity comprising contacting human TNF&agr; with an antibody such that human TNF&agr; activity is inhibited, wherein the antibody is an isolated human antibody, or an antigen-binding portion thereof, that dissociates from human TNF&agr; with a Kd of 1Ã—10âˆ’8 M or less and a Koff rate constant of 1Ã—10âˆ’3 sâˆ’1 or less, both determined by surface plasmon resonance, and neutralizes human TNF&agr; cytotoxicity in a standard in vitro L929 assay with an IC50 of 1Ã—10âˆ’7 M or less.