Patent ID: 6166216
Filing Date: 2000-12-26
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR49## wherein: Ar is phenyl, pyridyl, tetrahydronaphthyl, benzofuranyl or chromanyl substituted with zero to two substituents selected from the group consisting of --(C.sub.1 -C.sub.6)alkyl, hydroxy and halo; andsubstituted with:(i) one or two substituents selected from the group consisting of --O(CH.sub.2).sub.t R.sup.6, ##STR50## and --(C.sub.1 -C.sub.6 alkyl)R.sup.6 ; provided that when substituent pattern (i) is present, the phenyl or pyridyl group of Ar may additionally be substituted with two substituents which when taken together with the carbon atoms to which they are attached form a phenyl ring;where R.sup.6 is --NR.sup.7 R.sup.8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with --(C.sub.1 -C.sub.4)alkyl or ##STR51## and R.sup.7 and R.sup.8 are each individually hydrogen, --(C.sub.1 -C.sub.6)alkyl, --(CH.sub.2).sub.p OH, ##STR52## --(CH.sub.2).sub.p -piperidyl, --(CH.sub.2).sub.p S(C.sub.1 -C.sub.6)alkyl, --(CH.sub.2).sub.p O(C.sub.1 -C.sub.6)alkyl ##STR53## where R.sup.9 is (C.sub.1 -C.sub.6)alkyl; ---- represents a double or single bond;X is --O-- or --S--;Y is --CR.sup.5 'R.sup.5 --, --O-- or --S--, where R.sup.5 is H and R.sup.5 ' is --H or --OH or R.sup.5 ' and R.sup.5 taken together are .dbd.O;R is H or --(C.sub.1 -C.sub.6)alkyl;R.sup.1 and R.sup.2 are each individually --(C.sub.1 -C.sub.6)alkyl, --(C.sub.1 -C.sub.6)alkoxy or phenyl;q is 0 or 1;n is an integer from 0 to 4 both inclusive;p is an integer from 1 to 6 both inclusive; andt is an integer from 1 to 4 both inclusive;or a pharmaceutically acceptable salt, hydrate or optical isomer thereof.