Patent ID: 6603015
Filing Date: 2003-08-05
Classification: C07B,C07C,C07D,C07F

Abstract:
A method of synthesizing in high enantomeric excess an alcohol of the formula where R8 is selected from the group consisting of H, C1-C4 straight or branched chain alkyl, alkenyl or alkynyl groups, R9 is selected from the group consisting of H, C1-C10 straight and branched chain alkyl, alkenyl, alkynyl, hydroxyalkyl, hydroxyalkenyl and hydroxyalkynyl groups, substituted and unsubstituted cyclic, heterocyclic and aryl groups, X2 is O or S, Pâ€² is a protective group, and n4 is an integer which ranges from 1 to 4, said method comprising the step of: providing an enone compound of the formula â€ƒwhere R8, R9, X2, Pâ€² and n4 are as defined above; and asymmetrically reducing said enone compound in the presence of a chiral catalyst to obtain said alcohol.