Patent ID: 6958357
Filing Date: 2005-10-25
Classification: A61P,C07D

Abstract:
1. A method for treating disorders of the respiratory drive, comprising administering to a patient in need thereof an effective amount of at least one compound of Formula I in which: R1 and R5 are, independently of one another, H, F, Cl, Br, I, CN, alkyl having 1 to 4 carbon atoms, in which alkyl is unsubstituted or partially or completely substituted by fluorine; or R1 and R5 are cycloalkyl having 3 to 7 carbon atoms, which is unsubstituted or partially or completely substituted by fluorine; or R1 and R5 are OH or O-alkyl having 1 to 4 carbon atoms, in which alkyl is unsubstituted or partially or completely substituted by fluorine; or R1 and R5 are OCOR10, NR11R12, COR13, COOH, COOR14, CONR11R12, or —(O) R1 and R5 are O-phenyl, in which phenyl is unsubstituted or substituted by one to three substituents selected from F, Cl, Br, I, alkyl having 1 to 4 carbon atoms, OH, O-alkyl having 1 to 4 carbon atoms, NR16R17, CN, or (C R2, R3, and R4 are, independently of one another, H or F; R6, R7, R8, and R9 are, independently of one another, H, F, Cl, Br, I, CN, alkyl, or O-alkyl, in which the alkyl groups have 1 to 4 carbon atoms and are unsubstituted or partially or completely substituted by fluorine; or R6, R7, R8, and R9 are cycloalkyl having 3 to 7 carbon atoms, which is unsubstituted or partially or completely substituted by fluorine; or R6, R7, R8, and R9 are OH, OCOR24, or NR25R26;