Patent ID: 8853185
Filing Date: 2014-10-07
Classification: A61K,A61P,C07D,C07F,C07H,C40B

Abstract:
1. A therapeutic multimer comprising: a plurality of covalently or non-covalently linked monomers, each monomer comprising: a diversity element which binds to a target molecule with a dissociation constant less than 300 μM; and a linker element, having a molecular weight less than 500 daltons, and capable of forming a reversible covalent bond or non-covalent tight interaction with a binding partner linker element on another monomer, with a dissociation constant less than 300 μM, with or without a co-factor, under physiological conditions, wherein said diversity element and said linker element are joined together for each monomer directly or indirectly through a connector, the plurality of monomers being reversibly covalently bonded or non-covalently linked together through their linker elements, and the diversity elements of the therapeutic multimer bind to proximate locations of the target molecule, wherein the therapeutic multimer binds to the target molecule with a dissociation constant of less than 10 μM, wherein said linker element is selected from the group consisting of where R is an aliphatic or alicyclic group where Q is an aromatic, heterocyclic or nonheterocyclic ring where n=0-3, m=1-3 and p =1-2 where the lines crossed with a dashed line illustrate the one or more bonds formed joining the one or more diversity elements directly or through a connector to the linker element, and wherein the binding partner linker element is a 1,2-diol, or a 1,3 diol, whereby said linker element and its binding partner linker element, when bound together, form 5 or 6 membered boronate ester rings.