Patent ID: 6310082
Filing Date: 2001-10-30
Classification: A61K,A61P,C07D

Abstract:
A pharmaceutical composition comprising an effective poly(ADP-ribose)polymerase or PARP enzyme inhibiting amount of a benzimidazole compound having the structural formula I ##STR26##or a pharmaceutically acceptable salt and/or pro-drug form thereof, together with a pharmaceutically acceptable carrier,whereinR is selected from the group consisting of hydrogen, hydroxyalkyl and a phenyl group which is substituted with one or more substituents selected from the group consisting of NO.sub.2, N.sub.3, NHCOR.sub.3 (R.sub.3 being alkyl or aryl), CO.sub.2 R.sub.4 (R.sub.4 being H or alkyl), an amide, tetrazole, alkyl, hydroxyalkyl, CW.sub.3 or W (W being halogen), and CN, andR' is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, acyl and an optionally substituted phenyl group having the structural formula III: ##STR27##wherein R.sub.7, R.sub.8 and R.sub.10 are each selected independently from the group consisting of H, hydroxy, alkoxy, NO.sub.2, N.sub.3, NR.sub.5 R.sub.6 (R.sub.5 and R.sub.6 each being independently hydrogen, alkyl or alkoxy), NHCOR.sub.3 (R.sub.3 being alkyl or aryl), CO.sub.2 R.sub.4 (R.sub.4 being H or alkyl), an amide, tetrazole, alkyl, hydroxyalkyl, CW.sub.3 or W (W being halogen), and CN.