Patent ID: 6056926
Filing Date: 2000-05-02
Classification: B01J,C07K,C12Q,C40B

Abstract:
A method of synthesizing diverse compounds on a plurality of substrates comprising the steps of:a) in each of a first plurality of reaction vessels, providing a plurality of substrates;b) delivering through a pressurized delivery means a first compound to each of said reaction vessels wherein said delivery means is coupled to each of said reaction vessels and to a mixing vessel and can deliver selected reagents to said mixing vessel or to at least one of said plurality of reaction vessels and wherein the first compound in one of said reaction vessels is different from the first compound in selected other reaction vessels;c) in each of said reaction vessels, coupling said first compound to said substrates to produce an immobilized compound;d) isolating said immobilized compounds in each of said reaction vessels by introducing a pressurized medium into each of said reaction vessels and allowing any fluids contained within the vessel to drain from each of said vessels; ande) transferring said immobilized compounds through a pressurized transfer means to said mixing vessel, said transfer means comprising a common manifold connected to said mixing vessel and a plurality of flow lines connecting said plurality of reaction vessels to said common manifold, wherein said transfer means is coupled to each of said reaction vessels and to said mixing vesself) mixing said immobilized compounds;g) redistributing said immobilized compounds through said transfer means from said mixing vessel back to said plurality of reaction vessels;h) delivering through said pressurized delivery means a second compound to each of said reaction vessels; andi) coupling said second compound to said immobilized compounds.