Patent ID: 8809495
Filing Date: 2014-08-19
Classification: A61K,C07K

Abstract:
1. A method for imparting cell permeability to or enhancing cell permeability of a lipid membrane structure, comprising binding a peptide to the lipid membrane structure, wherein the peptide consists of an amino acid sequence selected from the group consisting of LX 1 X 2 X 1 X 1 X 1 L, LLX 2 X 1 X 1 X 1 L, LRQRRL (SEQ ID NO: 26), LKQKKL (SEQ ID NO: 39), LRQSSL (SEQ ID NO: 41), and LRQRDL (SEQ ID NO: 43), wherein L represents a leucine residue, R represents an arginine residue, Q represents a glutamine residue, K represents a lysine residue, S represents a serine residue, D represents an aspartic acid residue, T represents a threonine residue, E represents a glutamic acid residue, and N represents an asparagine residue, X 1 represents a polar amino acid residue selected from the group consisting of S, T, D, E, R and K, and X 2 represents a polar, non-charged and branched chain amino acid residue selected from the group consisting of Q and N, wherein the amino acid sequence does not comprise LRQRRRL (SEQ ID NO: 1), whereby the cell permeability of the lipid membrane structure bound to the peptide is imparted or enhanced as compared with the lipid membrane not bound to the peptide.