Patent ID: 6127396
Filing Date: 2000-10-03
Classification: A61P,C07D,Y02P

Abstract:
A compound selected from those of formula (I): ##STR89## wherein: A represents a benzene ring unsubstituted or substituted by from 1 to 4 identical or different groups selected from linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxy, polyhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, cyano, nitro, amino, alkylamino, dialkylamino, thioalkyl, sulphonylalkyl, sulphinylalkyl, carboxy, alkoxycarbonyl, alkylcarbonyloxy, formyl, carbamoyl, carboxamide, phenyl, benzyl, and halogen,B represents an imidazoline ring as represented in formula (Ia) or (Ib): ##STR90## X represents CR.sup.6 or CR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl),nitrogen or NR.sup.8 (wherein R.sup.8 represents hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl or benzyl),oxygen,sulphur or SO or SO.sub.2,Y represents CH or CH.sub.2 or a single bond (and, in that case, the ring containing X, Y and Z is represented by the formula (1c) ##STR91## Z represents carbon or CR.sup.4 wherein R.sup.4 represents hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl,R.sup.1, R.sup.2, R.sup.3, which may be the same or different, each represent hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl,optionally (R.sup.2 and R.sup.4) or (R.sup.1 and R.sup.4) form cyclopropane,R.sup.5 represents hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl or benzyl,the symbol ##STR92## means that the bonds can be single or double, it being understood that the valency of the atoms is respected,wherein alkyl is understood to mean linear or branched alkyl containing 1 to 6 carbon atoms,its tautomers, enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.