Patent ID: 6838475
Filing Date: 2005-01-04
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A compound, including enantiomers, stereoisomers, rotamers and tautomers of said compound, and pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formula I: wherein: R′ is COR 5 or B(OR) 2 , wherein R 5 is selected from the group consisting of: H, CF 3 , C 2 F 5 , C 3 F 7 , CF 2 R 6 , R 6 , and OCR 7 with R 7 being H, OH, OR 8 , CHR 9 R 10 , or NR 9 R 10 , wherein R 6 , R 8 , R 9 and R 10 are independently selected from the group consisting of H, alkyl, aryl, heteroalkyl, heteroaryl, cycloalkyl, cycloalkyl, arylalkyl, heteroarylalkyl, CH(R 1′ )COOR 11 , CH(R 1′ )CONR 12 R 13 , CH(R 1′ )CONHCH(R 2′ )COO R 11 , CH(R 1′ )CONHCH(R 2′ )CONR 12 R 13 , CH(R 1′ )CONHCH(R 2′ )R′, CH(R 1′ )CONHCH(R 2′ )CONHCH(R 3′ )COO R 11 , CH(R 1′ )CONHCH(R 2′ )CONHCH(R 3′ )CONR 12 R 13 , wherein R 1 ′, R 2 ′, R 3′ , R′, R 11′ , R 12 , and R 13 are independently selected from a group consisting of H, alkyl, aryl, heteroalkyl, heteroaryl, cycloalkyl, alkyl-aryl, alkyl-heteroaryl, aryl-alkyl and heteroaralkyl; Z is O, N, or CH; X is selected from the group consisting of: C═O, C═S and (CRR′) p is a number from 1-6; G is selected from the group consisting of: H, alkyl, aryl, heteroalkyl, heteroaryl, alkyl-aryl and alky-heteroaryl with the proviso that G may be additionally optionally and chemically-suitably substituted with U R R, and R R Y is selected from the group consisting of H, alkyl, aryl, heteroalkyl, heteroaryl, cycloalkyl, arylalkyl, heteroarylalkyl, and U, where U is selected from alkyl-aryl, aryl-heteroaryl, alkyl-heteroaryl, alkylcarbonyl, arylalkylcarbonyl, arylcarbonyl, heteroalkylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, alkyloxycarbonyl, alkyl-aryloxycarbonyl, aryloxycarbonyl, arylalkyloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkyloxycarbonyl, cycloalkyloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl-arylaminocarbonyl, arylaminocarbonyl, arylalkylaminocarbonyl, heteroarylaminocarbonyl, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, alkylsulfonyl, arylsulfonyl, alkyl-arylsulfonyl, arylalkylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, and heterocycloalkylsulfonyl with the proviso that U may be additionally optionally and chemically-suitably substituted with U U U may alternately represent an arylalkyloxy group; with said alkyl, heteroalkyl, alkenyl, heteroalkenyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl moieties may be optionally substituted, with said term “substituted” referring to optional and suitable substitution with one or more moieties selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heterocyclic, halogen, hydroxy, thio, alkoxy, aryloxy, alkylthio, arylthio, amino, amido, ester, carboxylic acid, carbamate, urea, ketone, aldehyde, cyano, nitro, sulfonamide, sulfoxide, sulfone, sulfonyl urea, hydrazide, and hydroxamate.