Patent ID: 6228985
Filing Date: 2001-05-08
Classification: A61K,C07C,C07D

Abstract:
A compound having the formula: ##STR126##wherein n is 0 or 1;R is --NH.sup.2 or ##STR127##wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, carboxy, carboxyalkyl, and carbamoyl;Q is R.sup.3 C(O)-- or ##STR128##wherein R.sup.5 is selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, and carbamoylalkyl, and R.sup.3 and R.sup.4 are selected from the group consisting of H, alkyl, alkoxy, arylalkoxy, aralkyl, heteroaralkyl, and carbamoylalkyl;the Q-NH--(CH.sub.2).sub.n -- and the --C(O)R substituents of the compound of formula I are independently positioned ortho, meta, orpara relative to the carbon atoms that form the bond between the two phenyl groups to which said substituents are bound, with the proviso that said substituents are not both positioned ortho; andthe Q-NH--(CH.sub.2).sub.n -- and the --C(O)R substituents of the compound of formula II are positioned meta orpara to each other;or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof.