Patent ID: 7384965
Filing Date: 2008-06-10
Classification: A61P,C07D

Abstract:
1. A compound of the structural Formula: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R26 and R27, are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (b) X is selected from the group consisting of a single bond, O, S, S(O) (c) U is an aliphatic linker of C (d) Y is selected from the group consisting of C, O, S, NH, and a single bond; (e) E is C(R3)(R4)A and wherein (f) B is selected from the group consisting of S, and O; (g) Z is N; (h) R8 is selected from the group consisting of hydrogen, C (i) R9 is selected from the group consisting of hydrogen, C (j) R10, R11 are each independently selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C (k) R32 is selected from the group consisting of a bond, hydrogen, halo, C (l) AL is a fused C (m) — is optionally a bond to form a double bond at the indicated position.