Patent ID: 8048870
Filing Date: 2011-11-01
Classification: A61K,A61P

Abstract:
1. A method of making a composition that is cytotoxic or antineoplastic and comprising a metal coordination complex of a silver(I) chiral α-organic acid coordination complex in a pharmaceutical carrier, wherein the metal coordination complex is crystalline and coordinates to one silver atom, and the chiral α-organic acid is tartaric acid, malic acid, lactic acid or mixtures thereof, the method comprising the steps of: (a) adding at least one inorganic acid to an aqueous solvent to provide a solution having a pH of 2.0 or less, then (b) adding at least one surfactant to the solution after step (a), then (c) adding at least one chiral α-organic acid to the solution after step (b), wherein the chiral α-organic acid is tartaric acid, malic acid, lactic acid or mixtures thereof, and then (d) adding at least one silver(I) salt to the solution after step (c), whereby the chiral α-organic acid and silver (I) from the silver(I) salt interact to form the silver(I) chiral α-organic acid complex.