Patent ID: 8796239
Filing Date: 2014-08-05
Classification: A61P,C12N

Abstract:
1. A double-stranded nucleic acid having structure (A) set forth below: wherein each of N wherein each of (N)x and (N′)y is an oligonucleotide in which each consecutive N or N′ is joined to the adjacent N or N′ by a covalent bond; wherein x=y=18; wherein the sequence of N wherein N wherein: N N N N wherein z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′ terminus of N wherein each of Z and Z′ is independently present or absent, but if present is independently 1-5 consecutive nucleotides, 1-5 consecutive non-nucleotide moieties or a combination of 1-5 nucleotides and non-nucleotide moieties, covalently attached at the 3′ terminus of the strand in which it is present; or a pharmaceutically acceptable salt of the double stranded nucleic acid.