Patent ID: 8101676
Filing Date: 2012-01-24
Classification: A61K,A61L

Abstract:
1. An osteogenic paste composition effective for the induction of new bone growth in a primate, comprising: a resorbable paste carrier comprising a macromolecular carrier material; demineralized bone matrix, wherein the demineralized bone matrix contains particles with a particle size of between about 0.10 and 1.00 mm, wherein the ratio of demineralized bone matrix to resorbable paste carrier is between about 1:4 and about 3:2 by weight; an osteogenic factor incorporated into the paste composition to stimulate osteoclasts to cause an increase in a rate of resorption of the macromolecular carrier material, when the paste is implanted in the primate; and a porous particulate mineral comprising tricalcium phosphate and hydroxyapatite in a weight ratio of tricalcium phosphate:hydroxyapatite of about 70:30 to about 95:5, the porous particulate mineral in an amount of at least 20% by volume of the composition, said amount being effective to provide a scaffold for bone ingrowth as the resorbable paste carrier is resorbed.