Patent ID: 7994326
Filing Date: 2011-08-09
Classification: A61K,C07D

Abstract:
1. A neuronal nitric oxide synthase inhibitor compound of a formula wherein X is selected from CR, N, O and S, and R is selected from H, methyl and substituted methyl moieties; m and n are integers independently selected from 0, 1 and 2, and 0<(m +n)≦2, and said heterocyclic ring is aromatic; R 1 is selected from H, alkyl, substituted alkyl and halogen moieties; Y is selected from CH, O, N and + NR 4 ; p and q are integers independently selected from 0, 1 and 2, and 1<(p +q)≦4; Z is selected from NH, O and NHC(O); R 2 is selected from H, alkyl, amino, hydroxyl, and substituted alkyl moieties; R 3 is selected from alkyl, substituted alkyl, hydroxyalkyl, substituted hydroxyalkyl, arylalkylaminoalkyl, substituted arylalkylaminoalkyl, arylalkyloxaalkyl substituted arylalkyloxaalkyl, arylalkylamidoalkyl, substituted arylalkylamidoalkyl, aminoalkyl, and substituted aminoalkyl moieties; R 4 is H; and cis and trans stereoisomers and salts thereof.