Patent ID: 7652049
Filing Date: 2010-01-26
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A compound having Formula I, or a pharmaceutically acceptable salt thereof, wherein Y is selected from the group consisting of —C(═O)— and —(CRR X is selected from the group consisting of —O—, —NH—, —N(C Z is selected from the group consisting of —C(═O)—, —S(O) Each R is independently selected from the group consisting of H, —C B is selected from the group consisting of A R R Wherein one of B and R A (a) an aromatic ring selected from phenyl and naphthyl; (b) a phenyl ring fused to a 5-7 membered non-aromatic cycloalkyl ring, which optionally comprises 1-2 double bonds; (c) a 5-6-membered heterocyclic ring having 1-4 heteroatoms independently selected from N, S, O, and —N(O)—, and optionally also comprising 1-3 double bonds and a carbonyl group, wherein the point of attachment of A (d) a benzoheterocyclic ring comprising a phenyl ring fused to a 5-6-membered heterocyclic ring having 1-2 heteroatoms independently selected from O, N, and —S(O) A (a) an aromatic ring selected from phenyl and naphthyl; (b) a phenyl ring fused to a 5-7 membered non-aromatic cycloalkyl ring, which optionally comprises 1-2 double bonds; (c) a 5-6-membered heterocyclic ring having 1-4 heteroatoms independently selected from N, S, O, and —N(O)—, and optionally also comprising 1-3 double bonds and a carbonyl group; (d) a benzoheterocyclic ring comprising a phenyl ring fused to a 5-6-membered heterocyclic ring having 1-2 heteroatoms independently selected from O, N, and S and optionally 1-2 double bonds; and (e) a —C wherein A Each R wherein for compounds in which R with the proviso that when B is A n is 0 or 1; p is an integer from 0-4; x is 0, 1, or 2; y is 1 or 2; R R