Patent ID: 6143327
Filing Date: 2000-11-07
Classification: A61K

Abstract:
A delayed release coated tablet comprising:(i) a core comprising bupropion hydrochloride and conventional excipients, free of stabilizer; and(ii) a first coating consisting essentially of a water-insoluble, water-permeable film-forming polymer, a plasticizer and a water-soluble polymer; and(iii) a second coating consisting essentially of a methacrylic polymer and a plasticizer therefor;exhibiting a dissolution profile such that after 2 hours, from 0 up to 30% of the bupropion hydrochloride is released, after 4 hours, from 3 to 22% of the bupropion hydrochloride is released, after 6 hours, from 15 to 38% of the bupropion hydrochloride is released, after 8 hours, more than 40% of the bupropion hydrochloride is released.