Patent ID: 7785802
Filing Date: 2010-08-31
Classification: A01K,A61K,C07H,C07K,G01N

Abstract:
1. An in vitro assay for identifying a compound which specifically binds and/or modulates the activity of a bitter taste receptor polypeptide wherein said bitter taste receptor polypeptide is selected from (1) the bitter taste receptor polypeptide in SEQ ID NO:18 or a polypeptide comprising only the transmembrane or extracellular region thereof; and (2) a bitter taste receptor polypeptide having at least 90% sequence identity to the polypeptide of SEQ ID NO:18 or polypeptide that contains a portion that is at least 90% identical to the transmembrane region of the bitter taste receptor polypeptide in SEQ ID NO:18 and further containing the extracellular region of another G protein coupled receptor or a polypeptide that contains a portion that is at least 90% identical to the extracellular region of the bitter taste receptor polypeptide in SEQ ID NO:18 and further containing the transmembrane region of another G protein coupled receptor polypeptide wherein said assay comprises: i: screening a compound for its specific binding to and/or effect if any on the activation of said bitter taste receptor polypeptide according to (1) or (2) and ii: identifying said compound as a potential bitter taste modulator if it specifically binds to and/or enhances or inhibits the activation of said bitter taste receptor polypeptide.