Patent ID: 6235730
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I): ##STR139##wherein R represents the formula (i): ##STR140##wherein each of R.sub.1 and R.sub.2, which may be the same or different, represents a cycloalkyl group with 3 to 7 carbon atoms; an aryl group; or a heteroaryl group with 1 to 3 heteroatoms selected from the group consisting of nitrogen, sulfur, and oxygen atoms, where each of the cycloalkyl, aryl, and heteroaryl group may be substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group with 1 to 4 carbon atoms, a lower haloalkyl group with 1 to 4 carbon atoms, a nitro group, a lower alkoxy group with 1 to 4 carbon atoms, an amino group, an amino group substituted with a lower alkyl group with 1 to 4 carbon atoms, a hydroxyl group, a phenoxy group, and a sulfo group, or the formula (ii): ##STR141##wherein each of A and B, which may be the same or different, represents an aromatic hydrocarbon ring; a cycloalkane ring with 3 to 7 carbon atoms; or a cycloalkene ring with 5 to 7 carbon atoms, where each of the aromatic hydrocarbon, cycloalkane, and cycloalkene ring may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group with 1 to 4 carbon atoms, a lower haloalkyl group with 1 to 4 carbon atoms, a hydroxyl group, a nitro group, a lower alkoxy group with 1 to 4 carbon atoms, an amino group, an amino group substituted with a lower alkyl group having 1 to 4 carbon atoms, and a sulfo group, X represents a single bond, a straight chain or branched lower alkylene group with 1 to 4 carbon atoms, a straight chain or branched lower alkenylene group with 2 to 4 carbon atoms, an oxygen atom, a sulfur atom, an imino group which may be substituted with a lower alkyl group with 1 to 4 carbon atoms, a carbonyl group, --O--Z--, --Z--O, --S--Z--, --Z--S--, --NH--Z--, --NR.sub.5 Z--, --Z--NH--, or --Z--NR.sub.5 --, where the lower alkylene or lower alkenylene group may have substituent(s) selected from the group consisting of a halogen atom, a hydroxyl group, a nitro group, a lower alkoxy group with 1 to 4 carbon atoms, an amino group, and a sulfo group, and where Z represents a lower alkylene group with 1 to 4 carbon atoms or a carbonyl group, and R.sub.5 represents a lower alkyl group with 1 to 4 carbon atoms; and Y represents a single bond, a straight chain or branched lower alkylene group with 1 to 4 carbon atoms, or a carbonyl group; n represents an integer of 1 to 4; andeach of R.sub.3 and R.sub.4, which may be the same or different, represents a hydrogen atom, a lower alkyl group with 1 to 4 carbon atoms, a halogen atom, a lower haloalkyl group with 1 to 4 carbon atoms, a hydroxyl group, an amino group or a nitro group,or a pharmaceutically acceptable salt thereof.