Patent ID: 8039452
Filing Date: 2011-10-18
Classification: A61K,A61P

Abstract:
1. An antifungal medicinal composition, comprising: (1) 0.3 to 5% by weight in volume in total with respect to the whole amount of the medical composition of a film-forming agent consisting of one or two or more selected from the group consisting of ethyl cellulose, hydroxypropyl methylcellulose phthalate, and an acrylic resin emulsion; (2) 3 to 8 fold with respect to the content of the film-forming agent of a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm consisting of a copolymer of oxyethylene and oxypropylene having 70 or more of polymerization degree, and containing a polyoxyethylene portion having a polymerization degree of 140 to 180 and a polyoxypropylene portion having a polymerization degree of 20 to 40; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof, wherein, R represents an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a methylene group, a lower alkenyl group, a halogen atom, a lower alkyl group substituted with a lower alkoxy group or a lower alkylthio group, or a group represented by a general formula (2) below wherein, R wherein the content of film-forming agent in the composition is 0.1 to 10% by weight in volume, and wherein the content of water-soluble plasticizer is 1 to 10 fold with respect to the content of the film-forming agent, and the antifungal medicinal composition forms a coating film when applied to an application target, the coating film being maintained on a nail or skin surface at least 12 hours from drying after application, and the coating film being removable with water.