Patent ID: 6569849
Filing Date: 2003-05-27
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I wherein R1 and R2 are hydrogen; andX is â€”CH2CH2â€” or â€”CH&boxH;CHâ€”; and Y is N; and r and s independently are 0, 1, 2, 3 or 4; and A is â€”(CR9R10)â€” wherein R9 and R10 independently are hydrogen, C1-6-unbranched alkyl, C3-6-branched alkyl or C3-7-cycloalkyl, such that when A is â€”CH2â€”, r+s&lE;3; and Z is selected from â€ƒand R11 is C3-6-alkyl or C1-6-alkoxy; and R12 is â€”(CH2)pCOR17 wherein p is 0 or 1; and wherein R17 is â€”OH, â€”NHR20 or C1-6-alkoxy, wherein R20 is hydrogen or C1-6-alkyl; and R13 is hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; or a pharmaceutically acceptable salt thereof; provided that when A is â€”CH2â€” and r+s is &lE;3, Z cannot be â€ƒwherein R17 is â€”OH or C1-6-alkoxy.