Patent ID: 6162951
Filing Date: 2000-12-19
Classification: B01J,C07C

Abstract:
Compounds of general formula (I) ##STR52## wherein R denotes C.sub.1-6 alkyl, C.sub.1-6 alkenyl, C.sub.1-6 -alkynyl or phenyl, wherein the C.sub.1-6 alkyl and phenyl groups may optionally be substituted by one or more substituents selected from the group consisting of F, Cl, Br, NO.sub.2, amino, naphthalene, anthracene, biphenyl, C.sub.1-6 alkyl, CF.sub.3, CN, OH, O--C.sub.1-6 alkyl, CO.sub.2 H, CHO, NHCO(C.sub.1-6 alkyl), CO.sub.2 (C.sub.1-6 alkyl), N(C.sub.1-6 alkyl)CO, benzyl, C.sub.5-6 cyclic ethers and C.sub.2-4 unsaturated hydrocarbon groups, and wherein the C.sub.1-6 alkyl group may optionally include one or more intervening heteroatoms or aryl groups in the chain, or R denotes CN, CO.sub.2 NHR.sup.3, (CH.sub.2).sub.n OR.sup.3, CO.sub.2 R.sup.3, benzyl, or Y--X--R.sup.4 ;R.sup.1 denotes R or H;R.sup.2 denotes phenyl, phenyl substituted by one or more C.sub.1-7 alkyl groups, O--C.sub.1-6 alkyl groups and/or halogen atoms, or R.sup.2 denotes a C.sub.3-7 cyclic aliphatic hydrocarbon group;R.sup.9 denotes H or together with R forms a 5, 6 or 7 membered hydrocarbon ring, optionally substituted by one or more C.dbd.O, OH or amine groups;Y denotes a straight or branched aliphatic chain, optionally incorporating one or more aromatic hydrocarbon group(s) or ether linkages in the chain, or an aromatic hydrocarbon group;X denotes CH.sub.2, CO.sub.2, O, CONH, NH, CONR.sup.2, NR.sup.2 or a valence bond;R.sup.3 denotes H, C.sub.1 -C.sub.10 alkyl, benzyl or phenyl; andR.sup.4 denotes H, C.sub.1 -C.sub.6 alkyl, an insoluble support, or a spacer group attached to an insoluble support;with the proviso that when R.sup.9 is H and R.sup.1 is R, then R.sup.1 and R are not unsubstituted C.sub.1-6 alkyl;and all enantiomers, mixtures, including racemic mixtures, and diastereomers thereof.