Patent ID: 7807828
Filing Date: 2010-10-05
Classification: A61P,C07D

Abstract:
1. A compound of Formula IV: or a pharmaceutically effective salt thereof, wherein: t is 1, 2, 3, or 4; R 2 , R 3 , R 5 , and R 6 are, independently, H, F, Cl, Br, OH, CH 3 , CF 3 , CH 2 CH 3 , CH(CH 3 ) 2 , OCH 3 , CH 2 OCH 3 , or CH 2 OCH 2 CH 3 ; R 9 and R 10 are H, CH 3 , or CH 2 CH 3 or R 9 and R 10 together with the carbon to which they are attached are connected to form a spiro ring of size 3, 4, 5, 6, or 7; and Z is selected from CO 2 H, CONHS(O) 2 -alkyl, CONHS(O) 2 -cycloalkyl, CONHS(O) 2 -heteroalkyl, or tetrazole.