Patent ID: 8852553
Filing Date: 2014-10-07
Classification: A61K,C07C,C07D

Abstract:
1. A method of detecting, imaging, and/or monitoring a patient comprising the steps of: administering to the patient a chelated imaging agent; and acquiring an image of the site of concentration of the chelated imaging agent in the patient by a diagnostic imaging technique; wherein the chelated imaging agent comprises: an imaging agent selected from the group consisting of a non-metallic isotope, an optical reporter, a paramagnetic metal ion, a ferromagnetic metal, a gamma-emitting radioisotope, a positron-emitting radioisotope and an x-ray absorber; and a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is N, O, S, or P; R R R wherein each R R R each R each R Pg is a thiol protecting group; and n′ is an integer from 1-3, wherein the compound of Formula (I) comprises at least one chelator moiety, wherein at least one of R