Patent ID: 8791087
Filing Date: 2014-07-29
Classification: A61K,A61P,C12N,C12Q

Abstract:
1. A method of upregulating a function of and/or the expression of a ‘C terminus of HSP70-Interacting Protein’ (CHIP) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded antisense oligonucleotide 15 to 30 nucleotides in length or a double stranded oligonucleotide 19-30 nucleotides in length wherein at least one strand of said at least one oligonucleotide leas at least 80% sequence identity to a reverse complement of a polynucleotide comprising 15 to 30 or 19-30 consecutive nucleotides within nucleotides 1 to 2074 of SEQ ID NO: 2 and 1 to 1237 of SEQ ID NO:3; thereby upregulating a function of and/or the expression of the ‘C terminus of HSP70-Interading Protein’ (CHIP) polynucleotide in patient cells or tissues in vivo or in vitro.