Patent ID: 8895566
Filing Date: 2014-11-25
Classification: A61P,C07D

Abstract:
1. A method of treating a disease or disorder mediated by increased AKT protein kinase activity comprising administering to a mammal having said disease or disorder an effective amount of a compound of formula I to inhibit activity of an AKT protein kinase: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: R R R R L is selected from: wherein the single wavy line is where L attaches to A and the double wavy line is where L attaches to the pyrimidine; A is: X is a direct bond from L to Y, CH Y is CH or N; Z is absent, CH G is phenyl optionally substituted with one to four R R R a is 0 or 1; b is 0, 1 or 2; and each R b is 1, R R c is 1 or 2; or b is 1, Z is CH