Patent ID: 6197966
Filing Date: 2001-03-06
Classification: C07D

Abstract:
A method for producing an optically active amino alcohol compound of the formula [3] ##STR20##whereinR.sup.1, R.sup.2 and R.sup.3 are the same or different and each is a hydrogen atom, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted aralkyl, or R.sup.1 and R.sup.1 or R.sup.2 and R.sup.3 in combination form an optionally substituted ring; andR.sup.4 and R.sup.5 are the same or different and each is a hydrogen atom, an optionally substituted lower alkyl, an optionally substituted aryl, an optionally substituted aralkyl or an acyl, or R.sup.4 and R.sup.5 in combination form an optionally substituted ring together with the adjacent nitrogen atom, or R.sup.4 and R.sup.5 in combination form an imide group or an azide group together with the adjacent nitrogen atom,an enantiomer thereof or a salt thereof, comprising reacting a mesoepoxide compound of the formula [1] ##STR21##wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, with a compound of the formula [2] ##STR22##wherein R.sup.4 and R.sup.5 are as defined above, and R.sup.6 is a hydrogen atom or a silyl group, in the presence of a mixed catalyst comprising a Lewis acid and a proton donor.