Patent ID: 8420784
Filing Date: 2013-04-16
Classification: A01K,A61P,C07K

Abstract:
1. An isolated or purified antibody, or fragment thereof, that specifically binds to an Interleukin-10 Receptor alpha protein (IL-10Rα), wherein said isolated or purified antibody reduces, inhibits, or competes for, the binding of an antibody selected from the group consisting of (a) and (b) to said IL-10Rα: (a) an antibody comprising a heavy chain variable (VH) region with three complementarity determining regions (CDRs) and a light chain variable (VL) region with three CDRs, wherein CDR1, CDR2 and CDR3 of the VH region comprise the amino acid sequences of SEQ ID NOs: 49, 50 and 51, respectively, and wherein CDR1, CDR2 and CDR3 of the VL region comprise the amino acid sequences of SEQ ID NOs: 56, 57 and 58, respectively; and (b) an antibody comprising a VH region with three CDRs and a VL region with three CDRs, wherein CDR1, CDR2 and CDR3 of the VH region comprise the amino acid sequences of SEQ ID NOs: 49, 52 and 51, respectively, and wherein CDR1, CDR2 and CDR3 of the VL region comprise the amino acid sequences of SEQ ID NOs: 56, 57 and 58, respectively, and wherein said isolated or purified antibody or fragment thereof binds to an epitope distinct from the epitope to which the antibody designated as 3F9 binds.