Patent ID: 7063829
Filing Date: 2006-06-20
Classification: C07K

Abstract:
1. A process for the detection or screening of molecules, having a modulating effect on the formation of actin cytoskeleton, and hence a modulating effect on cellular motility, said process comprising: a stage of placing a test molecule in the presence of a reagent in a medium containing actin and elements necessary for actin polymerization, followed by detecting any inhibition or activation of the actin polymerization process on the surface of said reagent, compared with a control, respectively demonstrating an inhibiting or stimulating effect on the formation of the actin cytoskeleton by the test molecule, and wherein said reagent comprises the WASP peptide fragment consisting of SEQ ID NO: 4, bound or adsorbed to a support capable of moving under the effect of actin polymerization, when said support bound to said fragment is placed in a medium containing the elements necessary for actin polymerization.