Patent ID: 6936440
Filing Date: 2005-08-30
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A nucleic acid encoding a variant of a wild type growth hormone, said variant having a non-naturally occurring amino acid sequence or a covalent modification, comprising: (a) a first mutation in a first region selected from the group consisting of (i) amino acid residue L15, R16, R19 and Q22, (ii) the C-terminal ⅔ of the loop linking helices 1 and 2, and (iii) the C-terminal ½ of helix 4; and (b) a second mutation in a second region selected from the group consisting of (i) a region corresponding to residue 1 to residue 15 of human growth hormone and (ii) a region corresponding to residue 106 to residue 128 of human growth hormone, numbered from the N-terminus.