Patent ID: 6734311
Filing Date: 2004-05-11
Classification: C07D

Abstract:
A compound having the formula Ia or a pharmaceutically acceptable salt thereof, whereinRbâ€² is H or Rb; R2 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl 5) cycloalkyl, 6) heterocyclyl, 7) CF3, 8) â€”C(O)Rd, 9) â€”CO2Rd, 10) â€”C(O)NRdRe, 11) â€”CN, 12) â€”ORd, 13) â€”OCF3, 14) â€”OC(O)Rd, 15) â€”S(O)mRd, 16) â€”S(O)mNRdRe, 17) â€”NRdRe, 18) â€”NRdC(O)Re, 19) â€”NO2; wherein alkyl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl are optionally substituted with one to four substituents independently selected from Ra;R4 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from Ra;R5 is 1) C1-10alkyl, 2) Ar1, 3) Ar1â€”C1-10alkyl, 4) Ar1â€”Ar2, 5) Ar1â€”Ar2â€”C1-10alkyl-, wherein the alkyl group is optionally substituted with one to four substituents selected from Ra, and Ar1 and Ar2 are optionally substituted with one to four substituents independently selected from Rb,R6 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10alkynyl, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents independently selected from Ra;R7 is 1) hydroxy, 2) C1-10alkoxy, 3) C2-10alkenyloxy, 4) C2-10alkynyloxy, 5) Cy-Oâ€”, 6) Cy-C1-10alkoxy, 7) amino, 8) C1-10alkylamino, 9) di(C1-10alkyl)amino, 10) Cy-C1-10alkylamino, wherein alkyl, alkenyl and alkynyl are optionally substituted with one to four substituents selected from Ra, and Cy is optionally substituted with one to four substituents independently selected from Rb;R8 is 1) hydrogen, 2) C1-10alkyl, 3) C2-10alkenyl, 4) C2-10 alkynyl, 5) aryl, 6) heteroaryl, 7) aryl C1-10alkyl, 8) heteroaryl C1-10alkyl, 9) â€”ORd, 10) â€”O(CRfRg)nNRdRe, 11) â€”OC(O)Rd, 12) â€”OC(O)NRdRe, 13) halogen, 14) â€”SRd, 15) â€”S(O)mRd, 16) â€”S(O)2ORd, 17) â€”S(O)mNRdRe, 18) â€”NO2, 19) â€”NRdRe, 20) â€”NRdC(O)Re, 21) â€”NRdS(O)mRe, 22) â€”NRdC(O)ORe, or 23) â€”NRdC(O)NRdRe, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl are optionally substituted with one to four substituents selected from a group independently selected from Rc;R9 is 1) hydrogen, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 5) cycloalkyl, 6) heterocyclyl, 7) aryl, 8) heteroaryl; 9) aryl C1-10alkyl, 10) heteroaryl C1-10 alkyl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl are optionally substituted with one to four substituents selected from a group independently selected from Rc;Ra is 1) hydrogen, 2) â€”ORd, 3) â€”NO2, 4) halogen 5) â€”S(O)mRd, 6) â€”SRd, 7) â€”S(O)2ORd, 8) â€”S(O)mNRdRe, 9) â€”NRdRe, 10) â€”O(CRfRg)nNRdRe, 11) â€”C(O)Rd, 12) â€”CO2Rd, 13) â€”CO2(CRfRg)nCONRdRe, 14) â€”OC(O)Rd, 15) â€”CN, 16) â€”C(O)NRdRe, 17) â€”NRdC(O)Re, 18) â€”OC(O)NRdRe, 19) â€”NRdC(O)ORe, 20) â€”NRdC(O)NRdRe, 21) â€”CRd(Nâ€”ORe), 22) CF3; or 23) â€”OCF3, 24) cycloalkyl, 25) heterocyclyl, 26) aryl; 27) heteroaryl; wherein cycloalkyl, heterocyclyl, aryl, heteroaryl are optionally substituted with one to four substituents selected from a group independently selected from Rc;Rb is 1) a group selected from Ra, 2) C1-10 alkyl, 3) C2-10 alkenyl, 4) C2-10 alkynyl, 8) aryl C1-10alkyl, 10) heteroaryl C1-10 alkyl, wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents selected from a group independently selected from Rc;Rc is 1) halogen, 2) amino, 3) carboxy, 4) cyano, 5) C1-4alkyl, 6) C1-4alkoxy, 7) aryl, 8) aryl C1-4alkyl, 9) heteroaryl, 10) hydroxy, 11) oxo, 12) CF3, or 13) aryloxy; Rd and Re are independently selected from hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, Cy and Cy C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Cy are optionally substituted with one to four substituents independently selected from Rc; or Rd and Re together with the atoms to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen; Rf and Rg are independently selected from hydrogen, C1-10alkyl, Cy and Cy-C1-10alkyl; or Rf and Rg together with the carbon to which they are attached form a ring of 4 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen; Cy is independently selected from cycloalkyl, heterocyclyl, aryl, or heteroaryl; Ar1 and Ar2 are independently selected from aryl and heteroaryl; m is an integer from 1 to 2; n is an integer from 1 to 10; Z and A are independently selected from â€”C- and â€”C-; B is selected from the group consisting of 1) a bond 2) â€”Câ€”3) â€”Câ€”Câ€”4) â€”C&boxH;Câ€”5) a heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; and 6) â€”S(O)mâ€”; Y is 1) a bond, or 2) â€”C(R8)(R9)â€”.