Patent ID: 6780981
Filing Date: 2004-08-24
Classification: C07H,C12Q,C40B

Abstract:
A method of making a set of labeled compounds, by the use of a support and a set of labels, said method comprising the steps of:a) at least one first or intermediate step comprising dividing the support into lots, performing a different chemical reaction on each lot of the support so as either to modify that lot of the support or to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining said lots of the support, and b) at least one intermediate or final step comprising dividing the support into lots, performing a different chemical reaction on each lot of the support, so as either to modify that lot of the support or to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different cleavable label, wherein the label is cleavable to give a charged species for mass spectrometry, whereby each different cleavable label is linked to a chemical moiety coupled to the support in a different step and forms with that chemical moiety a labeled compound which is separable from the support, and combining the said lots of the support.