Patent ID: 8129561
Filing Date: 2012-03-06
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
1. A process for preparing a compound of formula (I): wherein R (a) contacting a compound of formula (A): with a compound of formula (B): in the presence of an azodicarboxylate reagent and a phosphine reagent, or in the presence of a combined Mitsunobu reagent, to form a compound of formula (C): wherein X is halogen or triflate and PG (b) contacting the compound of formula (C) with a reducing agent to form a compound of formula (D): (c) contacting the compound of formula (D) with a compound of formula (E): in the presence of a palladium catalyst, optionally a copper salt and/or optionally an organic base to form a compound of formula (F): wherein PG (d) contacting the compound of formula (F) with hydrogen in the presence of a metal catalyst to form the compound of formula (G): (e) removing the PG