Patent ID: 6191134
Filing Date: 2001-02-20
Classification: C07D

Abstract:
A compound of Formula I ##STR45##whereinR is ##STR46##attached at N to the quinoxaline ring through --(CH.sub.2).sub.n -- at the b-position,X is methyl;Y is alkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, selected from the group consisting of 2- or 3-benzfuryl, 2- or 3-indolyl, 2- or 3-furanyl, 2- or 3- thienyl 2-, 3-, 4-, 5-, 6-, or 7-benzothienyl, aralkyl, aryl, heterocycloalkyl selected from the group consisting of 2- or 3-pyrrolidinyl, 2- or 3-tetrahydrofuranyl, and 2-, 3-, or 4-piperidinyl;or is --(CH).sub.p (R.sub.24)C(O)NR.sub.25 R.sub.26 wherein p is an integer of from 1 to 6, R.sub.24 is hydrogen and R.sub.25 and R.sub.26 are each independently hydrogen, alkyl;or is --(CH.sub.2).sub.q --R.sub.27 wherein q is an integer from 1 to 3 and R.sub.27 is a 4- to 7-membered heterocycle containing from one to four heteroatoms selected from oxygen, sulfur, and nitrogen, wherein said heterocycle is heterocycloalkyl selected from 2- or 3-pyrrolidinyl, 2- or 3-tetrahydrofuranyl, and 2-, 3-, or 4-piperidinyl, or heteroaryl selected from oxazolyl, oxadiazolyl, thiazolyl, 1,3,4-oxadiazolyl, 1,2,4-triazolyl, 1,3,4-thiadiazolyl, pyrrazolyl, imidazolyl, tetrazolyl, 1,3-oxazolyl, isoxazolyl, 1,2,3-triazolyl, 1,3,4-thiazolyl, or is --NR.sub.27a --R.sub.27b wherein 27a is hydrogen or alkyl, and 27b is as described in R.sub.27 ;n is 1;R.sub.1 is hydrogen;R.sub.2 is hydrogen;R.sub.3 is hydrogen:R.sub.4 is nitro, andR.sub.5 is methyl and is at the a-position.