Patent ID: 6387927
Filing Date: 2002-05-14
Classification: A61P,C07D

Abstract:
A compound of formula I whereinT is O, NH or N(alkyl), wherein alkyl is alkyl; A is a radical of formula Ia â€ƒwhich is bonded to the radical of the molecule according to formula I by one of the two carbon atoms marked with an arrow, and wherein X is S; O; NH; N(alk); wherein alk is alkyl, hydroxy-lower alkyl, unsubstituted or substituted amino-lower alkyl or carbamoyl-lower alkyl; N(ar), wherein ar is aryl; C(Rk*)&boxH;N, N&boxH;C(Rk*) or C(Rk*)&boxH;C(Rk**), wherein Rk* and Rk**, independently of one another, are H, alkyl, unsubstituted or substituted amino-lower alkyl, carbamoyl-lower alkyl, halogen-lower alkyl or hydroxy-lower alkyl; and Rk is H, alkyl, unsubstituted or substituted amino-lower alkyl, carbamoyl-lower alkyl, halogen-lower alkyl or hydroxy-lower alkyl; either Y is OH and Y* is hydrogen, or â€”Y and â€”Y* together form a bond (so that they form a double bond together with the adjoining bond connecting the two â€”Y and â€”Y* bearing carbon atoms); R is hydrogen, lower alkyl or halogen-lower alkyl; and Z is O, or â€”Zâ€” is a bond between the two binding carbon atoms; or salts thereof.