Patent ID: 6780436
Filing Date: 2004-08-24
Classification: A61K,A61P

Abstract:
A pellet comprising an acid labile benzimidazole compound, wherein the pellet comprises:(a) an inert nucleus; (b) a layer disposed over said inert nucleus (a), consisting of an acid labile benzimidazole compound, an inert, non-alkaline polymer soluble in water and one or more pharmaceutically acceptable inert excipient, wherein said inert excipients do not react in the conditions used; (c) one or more intermediate layers that comprise: (i) an inert, non-alkaline coating, formed of an inert, non-alkaline polymer soluble in water and one or more pharmaceutically acceptable inert excipients; and (ii) a system of modified release that comprises an inert, non-alkaline polymer soluble in water and an inert polymer insoluble in water, wherein the weight ratio of the inert, non-alkaline polymer soluble in water to the inert polymer insoluble in water is 50:85 to 15:50; said intermediate layer(s) (c) disposed over said layer (b) that covers the inert nucleus; and (d) an external layer comprising an enteric coating disposed over said intermediate layer(s) (c).