Patent ID: 6291694
Filing Date: 2001-09-18
Classification: C07C,C07D,C07F

Abstract:
A method of sterespecifically producing a compound of formula: ##STR38##or its enantiomer ##STR39##wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl and R.sup.2 is a hydroxy protecting group, which comprises reacting a compound of formula: ##STR40##or its enantiomer, respectively, ##STR41##wherein R.sup.1 and R.sup.2 are as above and the stereochemistry of the compound of formula 1BB, and the compound of formula 2BB is the same at carbons 1 and 3, respectively, and the stereochemistry of both the compound of formula 1BB* and the compound of formula 2BB* is the same at carbons 1 and 3, respectively, with a fluorinated alcohol having a pK.sub.a lower than about 9, in the presence of a palladium catalyst to yield the compound of formula 2BB or 2BB* respectively.