Patent ID: 6261550
Filing Date: 2001-07-17
Classification: A61K,A61P,C07K,Y02A

Abstract:
A G-CSF hybrid molecule comprising a G-CSF moiety and a protein moiety, wherein:(a) said G-CSF moiety comprises:(i) a G-CSF internal core of helices A, B, C and D as set forth in FIG. 4, said internal core helices comprising corresponding amino acid residues as set forth in SID. NO. 2;(ii) an external loop between helices A and B comprising corresponding amino acid residues as set forth in SID. NO. 2;(iii) an external loop between helices B and C comprising corresponding amino acid residues as set forth in SID. NO. 2;(iv) an external loop between helices D and A; and(v) an N-terminus and a C-terminus, said N-terminus being connected to helix D and said C-terminus being connected to helix C, said N-terminus and said C-terminus each comprising a portion of amino acids 120-146 of SID. NO. 2;(b) said protein moiety is connected to an amino acid of subpart (v).