Patent ID: 8846762
Filing Date: 2014-09-30
Classification: A61K,A61P,C07D,C07F

Abstract:
1. A method of treating breast cancer, prostate cancer or pharynx cancer in a mammal comprised of administering to said mammal a therapeutically effective amount of a compound of Formula I: or a stereoisomer, geometric isomer, tautomer, or pharmaceutically acceptable salt thereof, wherein: Z Z Z Z where X R A is selected from —C(═O)NR —CH 2 CO 2 CH 3 , —NH 2 , —NHC(═O)CH 3 , —OCH 3 , —S(O) 2 CH 3 , 1-methylpiperid-4-yl, 4-methylpiperazin-1-yl, 4-morpholinyl, isopropyl, isobutyl, cyclopropyl, cyclopropylmethyl, cyclobutyl, triazolylmethyl, benzyl, and phenyl, where alkyl, alkylene, benzyl and phenyl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CF 3 , —CH 2 OH, —CH 2 CO 2 H, —CN, —CH 2 NH 2 , —CH 3 , —C(═O)CH 3 , —C(═O)NHCH 3 , —CO 2 H, —CH 2 CO 2 CH 3 , —NH 2 , —OH, —OCH 3 , —S(O) 2 CH 3 , 1-methylpiperid-4-yl, (4-methylpiperazin-1-yl)carboxamide, —CH 2 (1H-1,2,4-triazol-5-yl), 4-methylpiperazin-1-yl, and 4-morpholinyl; R R or R R or R R