Patent ID: 6525070
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein:q=0 or 1;s=0; t=1; n and r are, independently, 0, 1, 2, 3, 4 or 5; p=1; m=1; X is O; Y is NHR2 or OH; T is C(O), C(S), S(O)2 or CH2; R1 is phenyl or naphthyl optionally substituted as presecribed below for aryl moieties; R2 and R47 are, independently, hydrogen, C1-6 alkyl, aryl(C1-4)alkyl or CO(C1-6 alkyl); R3 is aryl, optionally substituted as presecribed below; wherein, unless stated otherwise, the foregoing aryl moieties are optionally substituted by: (a) halogen, (b) OH, (c) SH, (d) NO2, (e) oxo, (f) C1-6 alkyl, the alkyl being optionally substituted by halogen, OC(O)C1-6 alkyl, S(O)2R48, phenyl, the phenyl being optionally substituted by halogen (such as one or two chlorine or fluorine atoms), C1-6 alkyl, S(O)2R38 or C(O)NR39R40) naphthyloxy, the naphthyloxy being optionally substituted by halo or C2-6 alkenyl, C3-10 cycloalkyl, the cycloalkyl being optionally substituted by C1-4 alkyl or oxo) or NR41C(O)OCH2(fluoren-9-yl); (g) NR41C(O)OCH2(fluoren-9-yl), (h) C1-6 alkoxy, the C1-6 alkox being optionally substituted by halogen, C1-6 alkoxy, NHCO2(C1-6 alkyl), CO2R4, NR5R6 or phenyl, the phenyl being optionally substituted by halogen or NO2; (i) C1-6 alkylthio, (j) C1-6 haloalkylthio, (k) C3-10 cycloalkyl, (l) NR7R8, (m) NR9C(O)R10, (n) CO2R11 (o) C(O)NR12R13, (p) C(O)R14, (q) S(O)dR15, (r) S(O)2NR42R43, (s) NR44S(O)2R45, (t) phenyl, the phenyl being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy, the alkoxy being optionally substituted by halogen, or OH, phenyl, the phenyl being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy, (u) phenoxy, the phenoxy being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy, C1-6 haloalkoxy, phenyl, the phenyl being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy, (v) SCN, (w) CN, (x) SO3H (or an alkali metal salt thereof), (y) methylenedioxy or (z) difluoromethylenedioxy; when aryl is phenyl adjacent substituents may join to form, together with the phenyl ring to which they are attached, a dihycfrophenanthrene moiety; d is 0, 1 or 2; R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R37, R39, R40, R41, R42, R43 and R44 are, independently, hydrogen, C1-6 alkyl, aryl, the aryl being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy; R15, R38, R45 and R48 are, independently, C1-6 alkyl, the alkyl being optionally substituted by halogen, hydroxy or C3-10 cycloalkyl, C3-6 alkenyl, aryl, the aryl being optionally substituted by halogen, C1-6 alkyl, C1-6 haloalkyl, CN, NO2, C1-6 alkoxy or C1-6 haloalkoxy; or an N-oxide thereof; or a pharmaceutically acceptable salt thereof; or a solvate thereof.