Patent ID: 6521780
Filing Date: 2003-02-18
Classification: C07B,C07C,C40B

Abstract:
A cycloalkyl compound of formula I wherein{circle around (P)} is a solid phase, {circle around (L)} is a linking moiety with 2 to 12 carbon atoms, or is CH2CH2â€”(Oâ€”CH2CH2)1-100, R1 is hydrogen, or is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, hetaryl, alkylaryl, alkylhetaryl, alkylcarbonyl, arylcarbonyl, alkylsulfonyl or arylsulfonyl of from 1 to 26 carbon atoms; R2 is hydrogen or unsubstituted or substituted alkyl, alkenyl, alkynyl or cycloalkyl, or R1 and R2 are linked to form an unsubstituted or substituted 4- to 8-membered ring, R3 is unsubstituted or substituted C1-C10-alkyl, C3-C8-cycloalkyl or aryl, R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, hetaryl, alkylaryl, alkylhetaryl, alkylcarbonyl, arylcarbonyl, alkylsulfonyl or arylsulfonyl of from 1 to 26 carbon atoms, or two adjacent R radicals are linked to form an unsubstituted or substituted carbo- or heterocyclic ring, n is 0 to 4, and m is 0 to n+2, which is obtained by preparing a compound of formula II by linking a compound of formula VII to a functionalized solid phase of formula V{circle around (P)}â€”Oâ€”{circle around (L)}â€”OHâ€ƒâ€ƒ(V) in the presence of a base, reacting the compound of formula II with an aldehyde of formula III in the presence of a base to give a compound of formula IV and cyclizing the compound of formula IV in the presence of a Lewis acid.