Patent ID: 6239121
Filing Date: 2001-05-29
Classification: A61P,C07J

Abstract:
A compound selected from the group consisting of a compound of the formula ##STR22##wherein R.sub.1 is selected from the group consisting of hydrogen, --(CH.sub.2).sub.m --Ar, --(CO)--Ar, --(CH.sub.2).sub.m Ar and --(CO)-Alk, R.sub.2 is optionally unsaturated alkyl of 1 to 6 carbon atoms, D forms with the carbons to which it is attached a 5 membered ring unsubstituted or substituted and saturated or unsaturated, X is halogen, Y is selected from the group consisting of --O--, --S--, --SO--, --SO.sub.2 -- and --NH--, n is an integer of 2 to 8, m is an integer from 0 to 3, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --(CH.sub.2).sub.m --Ar, and --(CH.sub.2).sub.m -Alk Ar is carbocyclic aryl of 6 to 8 carbon atoms, Alk is saturated or unsaturated alkyl and cycloalkyl of up to 12 carbon atoms, the Ar and Alk optionally substituted and its addition salts with non-toxic, pharmaceutically acceptable acid and bases.