Patent ID: 9175275
Filing Date: 2015-11-03
Classification: A61P,C12N,C12Y,Y02E,Y10T

Abstract:
1. An isolated, synthetic or recombinant polypeptide (i) having an amino acid sequence 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or more, or 100% sequence identity to SEQ ID NO:520, (ii) having an amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO:519; or (iii) having an amino acid sequence as set forth in (i) or (ii) and comprising at least one amino acid residue conservative substitution, wherein the conservative substitution comprises replacement of an aliphatic amino acid with another aliphatic amino acid; replacement of a serine with a threonine or vice versa; replacement of an acidic residue with another acidic residue; replacement of a residue bearing an amide group with another residue bearing an amide group; exchange of a basic residue with another basic residue; or, replacement of an aromatic residue with another aromatic residue, or a combination thereof, and the aliphatic residue comprises Alanine, Valine, Leucine, Isoleucine or a synthetic equivalent thereof; the acidic residue comprises Aspartic acid, Glutamic acid or a synthetic equivalent thereof; the residue comprising an amide group comprises Aspartic acid, Glutamic acid or a synthetic equivalent thereof; the basic residue comprises Lysine, Arginine or a synthetic equivalent thereof; or, the aromatic residue comprises Phenylalanine, Tyrosine or a synthetic equivalent thereof; wherein the polypeptide has a heterologous signal sequence or a heterologous pepro sequence, and wherein the polypeptide has an oligomerase activity.