Patent ID: 7790725
Filing Date: 2010-09-07
Classification: A61P,C07D

Abstract:
1. A thiazolidine derivative represented by the formula (I): wherein X is a substituent of the following formula: wherein m is an integer of 1, A is a carbon atom or a nitrogen atom, Q is aryl or heteroaryl selected from the compounds represented by the following formulas (II)-(XII): wherein (i) in the formula (II), 1 to 3 from a, b, c and d is(are) nitrogen atom(s) and the rest is(are) carbon atom(s) or all of them are nitrogen atoms, R R (ii) in the formula (III), one of e and f is a nitrogen atom and the other is a carbon atom, or both are carbon atoms, and R (iii) in the formula (IV), j is a sulfur atom, an oxygen atom or a nitrogen atom, h and i may be the same or different and each is a nitrogen atom or a carbon atom, R R (iv) in the formula (V), k, l and n′ may be the same or different and each is a carbon atom or a nitrogen atom, wherein at least one is a carbon atom, R R R R 10 is a hydrogen atom or cyano (when 1 is a nitrogen atom, then R 10 is absent), (v) in the formula (VI), p is a nitrogen atom or a carbon atom, R R R (vi) in the formula (VII), one of r and s is a nitrogen atom and the other is a carbon atom, R R R (vii) in the formula (VIII), r′ and s′ may be the same or different and each is a carbon atom or a nitrogen atom, wherein at least one of them is a nitrogen atom, R R R (viii) in the formula (IX), t is a sulfur atom or an oxygen atom, u is a carbon atom or a nitrogen atom, and R (x) in the formula (XI), R Y is methylene, hydroxymethylene, a sulfur atom, sulfinyl or sulfonyl; and Z is a hydrogen atom or cyano; wherein when X is a substituent represented by the formula (I-a), then Z is a hydrogen atom, or a pharmaceutically acceptable salt thereof.