Patent ID: 8663697
Filing Date: 2014-03-04
Classification: A61J,A61K,A61P,B05D

Abstract:
1. A granule of a solid dispersion comprising a poorly water-soluble drug, a water-soluble polymer, an excipient and a disintegrator, wherein a content of the water-soluble polymer is 1 to 10% by weight and a content of the disintegrator is 15 to 50% by weight; the water-soluble polymer is selected from the group consisting of alkylcellulose, hydroxyalkylcellulose, hydroxyalkylalkylcellulose, polyvinyl alcohol and polyvinyl pyrrolidone; the disintegrator is low-substituted hydroxypropylcellulose having 5 to 16% by weight of hydroxypropoxyl groups; and molecules of the poorly water-soluble drug in an amorphous state are dispersed in the water-soluble polymer as a result of dissolution of the poorly water-soluble drug and the water-soluble polymer in a solvent.