Patent ID: 6028086
Filing Date: 2000-02-22
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR7## or a pharmaceutically acceptable salt thereof; wherein a is 0, 1, 2, 3 or 4;b is 0, 1, 2, 3 or 4;V is O or S;W is (C.sub.2 -C.sub.12)alkyl or (C.sub.3 -C.sub.12)alkenyl;X is O or NR.sup.3 ;Y is (C.sub.1 -C.sub.12)alkyl or (C.sub.3 -C.sub.12)alkenyl;Z is (C.sub.6 -C.sub.10)aryl, (C.sub.3 -C.sub.7)cycloalkyl or a saturated or unsaturated (C.sub.4 -C.sub.7) heterocyclic group containing as the heteroatom one or two of the group consisting of oxygen, sulphur, sulphonyl, nitrogen and NR.sup.4 wherein R.sup.4 is hydrogen or (C.sub.1 -C.sub.4) alkyl;R.sup.1 is (C.sub.1 -C.sub.4)alkyl;R.sup.2 is halo, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy; andR.sup.3 is hydrogen or (C.sub.1 -C.sub.4)alkyl;wherein each alkyl, alkoxy, cycloalkyl, aryl or heterocyclic group may optionally be substituted by 1 to 6 halo, (C.sub.1 -C.sub.4)alkyl, trifluoromethyl, hydroxy, (C.sub.1 -C.sub.4)alkoxy, cyano, nitro, (C.sub.2 -C.sub.4)alkenyl, (C.sub.3 -C.sub.6)cycloalkoxy, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, CO.sub.2 R.sup.6 and SO.sub.2 NR.sup.5 R.sup.6 groups wherein R.sup.5 and R.sup.6 are each independently hydrogen or (C.sub.1 -C.sub.4)alkyl;with the proviso the sum of the atoms defined by W, X and Y is 2 to 18.