Patent ID: 8545839
Filing Date: 2013-10-01
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for inhibiting the growth and/or the proliferation of tumor cells with genic amplification of c-Met, the method comprising administering to a subject in need thereof an isolated anti-cMet antibody, or binding fragment thereof, that is capable to inhibit c-Met dimerization, wherein the antibody comprises: a heavy chain comprising complementarity-determining region (CDR) CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences SEQ ID Nos. 1, 2, and 3, respectively; a light chain comprising CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences SEQ ID Nos. 5, 6, and 7; and a modified hinge region comprising the amino acid sequence SEQ ID No. 56.