Patent ID: 7173030
Filing Date: 2007-02-06
Classification: A61K,C07D

Abstract:
1. A method for promoting wound healing or for the treatment of a disease or disorder, selected from type-2 diabetes, obesity, glaucoma, hyperlipidemia, hyperglycemia, hypertension, osteoporosis, and depression, said method comprising administering to a mammal, including a human, in need of such treatment an effective amount of a compound of formula (I) wherein T is selected from: 2-acetylamino-4-methylthiazol-5-yl; benzyl; 5-bromo-6-chloropyridin-3-yl; 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl; 2,3-dihydro-1,4-benzodioxin-6-yl; 2,3-dihydro-1-benzofuran-5-yl; 5-(dimethylamino)-1-naphthyl; 1,2-dimethyl-1H-imidazol-4-yl; 3,5-dimethylisoxazol-4-yl; 4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl; 1-methyl-1H-imidazol-4-yl; 5-methyl-2-(trifluoromethyl)-3-furyl; 4-morpholin-4-ylpyridin-3-yl; 1-naphthyl; 2-naphthyl; 2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl; 6-phenoxypyridin-3-yl; quinolin-8-yl; 1,3,5-trimethyl-1H-pyrazol-4-yl; thienyl optionally substituted with one or more of acetylamino; chloro; methyl; 2-(methylthio)pyrimidin-4-yl; nitro; phenylsulfonyl; pyridinyl; phenyl optionally substituted with one or more of acetyl; acetylamino; amino; 4-(1,3-benzothiazol-2-ylthio)acetylamino; benzoylamino; bromo; chloro; 3-chloro-2-cyanophenoxy; (5-chloro-2-hydroxybenzyl)amino; 4-chloro-3-nitrophenylcarbonylamino; [(4-chlorophenyl)amino]carbonylamino; cyano; 2,4-dichlorophenoxyacetylamino; fluoro; 4-{[(4-fluorophenyl)amino]carbonothioyl}amino; 4-fluorophenylcarbonylamino; hydroxy; methoxy; methyl; 5-methyl-1,3,4-oxadiazol-2-yl; (4-methylphthalazin-1-yl)amino; 1,3-oxazol-5-yl; 2-methyl-4-pyrimidyl; n-butoxy; nitro; N-phthalimido; phenoxy; phenyl; 1H-pyrazol-1-yl; tert-butyl; tetrazolyl; 2,2,2-trifluoroethoxy; trifluoromethoxy; trifluoromethyl; R 1 is hydrogen or methyl; A 1 and A 2 are a nitrogen atom or C—Z, provided that A 1 and A 2 have different meanings, wherein: Z is [(1,3-benzodioxol-5-ylaminocarbonyl)methyl]thio; n-butylthio; (R)-2-[(3-chloro-2-methylbenzenesulfonyl)oxy]propyl; cyclohexyl; cyclopropyl; ethoxycarbonylmethylthio; ethylthio; (R)-2-[(3-fluorophenyl)thio]propyl; 3-furyl; methoxy; 2-methylpyridin-3-yl; morpholin-4-yl; (R)-1-phenoxy-n-propyl; phenyl; (R)-1-phenyl-n-propyl; tert-butyl; tert-butylphenyl; 2-thienyl; 3-thienyl; (trichloromethyl); (trifluoromethyl); A A X is CH Y is CH R 2 is selected from: 4-acetylaminophenylsulfonyl; 1-(3-chloro-2-methylphenylsulfonyloxyl)ethyl; 1-[(3-fluorophenyl)thio]ethyl; 4-chlorophenyl; 3-ethoxy-n-propyl; hydrogen; isopropyl; 4-methoxyphenyl; methyl; phenylsulfonyl; pyridin-3-yl; tert-butyl; NR NR R R with the proviso that T is not selected from 4-acetylaminophenyl, 4-aminophenyl, 4-(4-chloro-3-nitrophenylcarbonylamino)phenyl, 4-{[(4-chlorophenyl)amino]carbonylamino}-phenyl, 4-(2,4-dichlorophenoxyacetylamino)phenyl, 4-({[(4-fluorophenyl)amino]-carbonothioyl}amino)phenyl, 4-methoxyphenyl, phenyl, 4-(N-phthalimido)phenyl, and 3-(trifluoromethyl)phenyl; and with the proviso that when R 1 is hydrogen and A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A