Patent ID: 6187593
Filing Date: 2001-02-13
Classification: A61K,C07K,G01N,Y10S

Abstract:
A method for utilizing a monoclonal antibody in conjugation with a cytotoxic reagent for the treatment of a fibrin encapsulated tumor comprising administering to a human in need of said treatment a monoclonal antibody in conjugation with a cytotoxic reagent, the improvement comprising employing for said monoclonal antibody a fibrin-specific monoclonal antibody that is MH-1 produced by hybridoma ATCC 9739 or an immunoreactive fragment thereof, or an antibody or an immunoreactive fragment thereof that competitively inhibits the immunospecific binding of the MH-1 antibody produced by hybridoma ATCC HB 9739 to MH-1's target antigen.