Patent ID: 7241603
Filing Date: 2007-07-10
Classification: A61L,A61P,C07K

Abstract:
1. A pharmaceutical preparation comprising fibrinogen at a concentration of at least 70 mg/ml, a fibronectin:fibrinogen ratio from 0.02 to 0.2, a viscosity of 150 cSt at the most at 20° C., and an osmolarity of less than 500 mOsm, wherein the pharmaceutical preparation, after mixing with a thrombin CaCl 2 solution, forms a non-transparent clot of physiological fibrin structure, and wherein the preparation further contains a solubility-improving substance containing a benzene, pyridine, piperidine, pyrimidine, morpholine, pyrrole, imidazole, pyrazole, furan, thiazole, or purin-containing group, wherein the solubility-improving substance is present at a concentration of 150 mM at the most.