Patent ID: 6512106
Filing Date: 2003-01-28
Classification: C07H

Abstract:
A purine base, purine nucleoside or purine nucleotide modified at the 2-, 6- or 8-position of the purine ring prepared according to a method comprising the steps of:reacting a purine starting material containing a leaving group attached to the 2-, 6- or 8-position of said purine starting material with a finctionalized alkene having the formula: â€ƒwherein Y is selected from the group consisting of â€”CHROH; R is selected from the group consisting of H, substituted or unsubstituted alkyl, alkenyl and aryl; and n is an integer from 0-15 â€ƒin the presence of a palladium catalyst of the general formula PdL3 or PdL4, wherein L is a ligand of palladium; and isolating said modified nucleoside or nucleotide.