Patent ID: 8790664
Filing Date: 2014-07-29
Classification: A61K,A61P

Abstract:
1. A stabilized multimodular assembly useful for intracellular delivery comprising: a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein said complex has a theoretical charge ratio ranging from about 0 to about 4, the theoretical charge ratio being defined as a number of moles of positive charges per mole of negative charges, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to said complex, said amphiphilic block co-polymer comprising hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand, and wherein said amphiphilic block co-polymer is an A-B-A type linear block co-polymer of the following formula (III) or formula (IV):