Patent ID: 6610630
Filing Date: 2003-08-26
Classification: B01J,C07K

Abstract:
A pseudobioaffinity chromatography adsorbent for use in selectively adsorbing immunoglobulins, comprising a solid support material and a ligand immobilized on the surface of the solid support material through a covalent mercapto linkage,wherein the ligand is a compound having the formula: wherein each of X1, X2 and X3 is selected from the group consisting of S, SCH3+, O, NH, NCH3, CH2 and CR1R2, X1 is selected from the group consisting of N, NCH3+, CH and CR, R is selected from the group consisting of alkyl, substituted alkyl, aryl, alkenyl, alkynyl, aralkyl, acyl, cycloalkyl, carboxyl, amino, aryloxy or alkoxy, halo, hydroxy, nitro, O, S, and cyano, and R1 and R2 are selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, alkenyl, alkynyl, aralkyl, acyl, cycloalkyl, carboxyl, amino, aryloxy or alkoxy, halo, hydroxy, nitro, O, S, and cyano, with the proviso that at least one of R1 and R2 is not hydrogen, and wherein at least two of X1, X2, X3, and X4 are not CH2, CH, CR or CR1R2.