Patent ID: 8673898
Filing Date: 2014-03-18
Classification: A61P,C07D

Abstract:
1. A method of treating cancer, comprising administering to a mammal in need thereof an effective amount of a compound of the Formula and tautomers and pharmaceutically acceptable salts thereof, wherein: said cancer is selected from biliary tract cancer, brain cancer, breast cancer, cervical cancer, choriocarcinoma, colon cancer, endometrial cancer, esophageal cancer, gastric cancer, intraepithelial neoplasms, leukemia, lymphoma, liver cancer, lung cancer, melanoma, neuroblastomas, oral cancer, ovarian cancer, pancreatic cancer, prostate cancer, rectal cancer, renal cancer, sarcomas, skin cancer, testicular cancer, thyroid cancer, other carcinomas and sarcomas; Z is H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, OR R or R or R each R R n is 0, 1, 2, 3 or 4; such that said cancer is treated.