Patent ID: 7301021
Filing Date: 2007-11-27
Classification: A61K,C07D,C12Q,Y02A

Abstract:
1. A process for preparing a compound of Formula (I) wherein R Y is oxygen or sulfur; R Z is oxygen or sulfur; n is an integer having a value of 1 to 10; m is 0, or the integer 1 or 2; m′ is an integer having a value of 1 or 2, m″ is 0, or an integer having a value of 1 to 5; v is 0, or an integer having a value of 1 or 2; R A is an optionally substituted aryl, heterocyclyl, or heteroaryl ring, or A is a substituted C R R R R R R R R R R R R R R R  or a pharmaceutically acceptable salt thereof; which comprises reacting a compound of the Formula (II): with a imine compound of the Formula (III): wherein p is 0 or 2; and a base strong enough to deprotonate the isonitrile moiety of Formula (II); and R 11 , R 2 and R 4 are as defined in Formula (I), or are precursors of the groups R 1 , R 2 and R 4 and Ar is an optionally substituted phenyl group, and thereafter if necessary, converting a precursor of R 1 , R 2 and R 4 to a group R 1 , R 2 and R 4 .