Patent ID: 6770672
Filing Date: 2004-08-03
Classification: C07D

Abstract:
A compound having a structural formula wherein X is oxygen, nitrogen or sulfur; Y is oxygen or NR6; R1 is R7, â€”C1-4alkylene-Oâ€”C1-4alkyl, â€”C1-10alkylene-COâ€”SH, â€”C1-4alkylene-COâ€”S(C1-4alkyl), â€”C1-4alkylene-CSâ€”NH2, saccharide, alkoxy-linked saccharide, â€”C1-4alkylene-COâ€”NH(2âˆ’n)(C1-4alkyl)n, wherein n is 2 or 1, â€”C1-4alkylene-SO2â€”O(C1-4alkyl), â€”C1-4alkylene-OSO2â€”O(C1-4alkyl), â€”C1-4alkylene-OP(Oâ€”C1-4alkyl)3, or â€”C1-10alkylene-CN; R2, R3 are independently hydrogen, â€”C1-4alkyl, â€”CH2(C6H4)C1-4alkylene-COOH), â€”C1-4alkylene-COOâ€”CH2(C6H5), â€”C1-4alkylene-COâ€”NHâ€”CH2(C6H5), saccharide, â€”C1-4alkylene-Câ€”NH(2âˆ’n)(C1-4alkyl)n wherein n is 2 or 1; R4 is C1-4alkyl, â€”CH2(C6H4)C1-4alkylene-COOH), â€”C1-4alkylene-COOâ€”CH2(C6H5), â€”C1-4alkylene-COâ€”NHâ€”CH2(C6H5), saccharide, â€”C1-4alkylene-COâ€”NH(2âˆ’n)(C1-4alkyl)n wherein n is 2 or 1; R5 is methyl or R8; R6is hydrogen or â€”C1-4alkyl R7 is â€”C1-10alkylene-COOH, â€”C1-4alkylene-CONH2, â€”C1-4alkylene-COOâ€”C1-4alkyl, â€”C1-4alkylene-CON(C1-4alkylene-COOH)2, â€”C1-4alkylene-OH, â€”C1-4alkylene-NH3-halo or â€”C1-4alkylene-OSO2NH(C1-4alkyl); and R8 is â€”C7-17alkyl, â€”COOH, â€”C7-17 olefinic group containing 3 to 5 ethylenic bonds, â€”C&boxH;Câ€”COOâ€”C1-4alkyl, or â€”C1-4alkylene-COOâ€”C1-4 alkyl; wherein when X and Y are O, R1 is R7, R2, R3 are independently hydrogen or C1-4alkyl; R4 is C1-4alkyl; and R5 is R8; with the proviso that R7 can not be â€”C2-4alkylene-COOH, â€”C1-4alkylene-CONH2 nor â€”C1-4alkylene-OH when R2, R3, R4 are each methyl and R8 is a C16 alkyl.