Patent ID: 8455625
Filing Date: 2013-06-04
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A conjugate comprising: (i) a native or recombinant, full-length, mammalian IL 12 p35 subunit conjugated downstream of a first antibody molecule as a first fusion protein, wherein said IL 12 p35 subunit comprises an amino acid sequence that has at least 95% sequence identity with the amino acid sequence of human IL 12 p35 subunit as set out in SEQ ID NO: 4; and (ii) a native or recombinant, full-length, mammalian IL 12 p40 subunit conjugated upstream of a second antibody molecule as a second fusion protein, wherein said IL 12 p40 subunit comprises an amino acid sequence that has at least 95% sequence identity with the amino acid sequence of human IL 12 p40 subunit as set out in SEQ ID NO: 3, wherein the first and second antibody molecules are single chain Fv (scFv) molecules, wherein at least one of said first and second antibody molecules specifically binds to an extracellular matrix component associated with at least one of neoplastic growth and angiogenesis, and wherein (i) and (ii) are linked through heterodimerization of the p35 and p40 subunits.