Patent ID: 6429313
Filing Date: 2002-08-06
Classification: A61K,A61P,C07D,C07K

Abstract:
A process for preparing 1,3-dioxo-8a(S)-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-hexahydro-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester comprising reacting 8a-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-tetrahydro-imidazo([1,5-a]pyrazine-1,3dione with D-tartaric acid in a reaction inert solvent at 0Â° C. to about room temperature for about 5 minutes to about 48 hours.