Patent ID: 6262282
Filing Date: 2001-07-17
Classification: A61P,C07J

Abstract:
17.beta.-allyloxy(thio)alkyl-androstane compounds having the general formula I ##STR5##whereinR.sub.1 is (H,OR), (H,OSO.sub.3 H) or NOR; with R being H, (C.sub.1-6)alkyl or (C.sub.1-6)acyl;each of R.sub.2 and R.sub.3 is independently hydrogen or (C.sub.1-6)alkyl;n is 0, 1 or2;X is O, S, S(O) or S(O).sub.2 ;each of R.sub.4 and R.sub.5 is independently hydrogen or (C.sub.1-4)alkyl;each of R.sub.6, R.sub.7 and R.sub.8 is independently hydrogen, phenyl, halogen or (C.sub.1-4)alkyl, optionally substituted by hydroxy, (C.sub.1-4)alkoxy or halogen; orR.sub.7 and R.sub.8 together with the carbon atom to which they are bound form a (C.sub.3-6)cycloalkane ring; orR.sub.6 and R.sub.7 together with the carbon atoms to which they are bound form a (C.sub.5-6)cycloalkene ring; andwherein the dotted lines indicate a .DELTA..sup.7 or a .DELTA..sup.8 double bond, or a pair of conjugated double bonds selected from .DELTA..sup.7,14, .DELTA..sup.8,14 and .DELTA..sup.6,8(14) ;or a pharmaceutically acceptable salt thereof.