Patent ID: 6585971
Filing Date: 2003-07-01
Classification: A61K,A61P,C12N,C12Y

Abstract:
A method of treating diseases caused all or in part by a deficiency in &agr;-L-iduronidase, comprising the steps of:(a) administering a pharmaceutical composition comprising a purified human recombinant &agr;-L-iduronidase having a purity of greater than about 99%, wherein said purified human recombinant &agr;-L-iduronidase comprises the amino acid of residue 26 to 653 of SEQ ID NO:2, to a human subject in need thereof, and (b) optimizing said treatment by evaluating biochemical and clinical symptoms of said subject through routine assessment of history, physical examination, echocardiography, electrocardiography, magnetic resonance imaging, polysomnography, skeletal survey, range of motion measurements, corneal photographs, and skin biopsy.