Patent ID: 7741286
Filing Date: 2010-06-22
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A conjugate formed by a method comprising covalently coupling a modified kringle 5 peptide with human serum albumin, wherein the modified kringle 5 peptide comprises a kringle 5 peptide and a maleimido group coupled to the kringle 5 peptide, optionally via a linking group; wherein the kringle 5 peptide is a peptide fragment of amino acid residues 443 to 546 of SEQ ID NO: 1, of between 4 and 104 amino acids, and optionally having an amino acid substitution at Cys wherein the maleimido group and optional linking group is optionally coupled to the kringle 5 peptide by one or more additional amino acids; wherein the kringle 5 peptide is optionally coupled to an N-terminal protecting group; wherein the kringle 5 peptide has an α-C-terminal carboxy, an α-C-terminal carboxamide, or an α-C-terminal alkylcarboxamide; wherein said maleimido group reacts with a thiol group of Cys