Patent ID: 6391889
Filing Date: 2002-05-21
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound represented by formula (I): or a salt, a hydrate, a hydrate of the salt or a stereochemically pure isomeric form thereof, wherein R1 and R2 each independently represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may be substituted with one or more substituents selected from the group consisting of a hydroxyl group, a halogen atom, an alkylthio group having 1 to 6 carbon atoms, and an alkyoxy group having 1 to 6 carbon atoms; n represents an integer of 1 to 3; Q represents a partial structure having formula:wherein R3 represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a halogenoalkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms which may be substituted with a halogen atom, a phenyl group which may have 1 to to 3 substituents selected from the group consisting of a halogen atom, lower alkyl group having 1 to 6 carbon atoms, a hydroxyl group, a nitro group, or a lower alkoxyl group having 1 to 6 carbon atoms, an alkoxy group having 1to 6 carbon atoms, or an alkylamino group having 1 to 6 carbon atoms; R4 represents a hydrogen atom or an alkylthio group having 1 to 6 carbon atoms; R5 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms, in which the amino group may be substituted with one or more substituents selected from the group consisting of a formyl group, an alkyl group having 1 to 6 carbon atoms, and an acyl group having 2 to 5 carbon atoms; X1 represents a halogen atom or a hyrogen atom; and A represents a partial structure represented by formula (II): wherein X2 represents a hydrogen atom, an amino group, a halogen atom, a cyano group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms, in which the amino group may be substituted with one or more substituents selected from the group consisting of a formyl group, an alkyl group having 1 to 6 carbon atoms and an acyl group having 2 to 5 carbon atoms; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5 -alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, or a phenylalkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof; and the two substituents on the cyclopropane ring, are in a cis-configuration.