Patent ID: 8840915
Filing Date: 2014-09-23
Classification: A61K

Abstract:
1. A liquid polymeric pharmaceutical composition for controlled release of a therapeutic polypeptide, comprising effective amounts of: (a) a pharmaceutically acceptable, water insoluble, biodegradable polymer selected from the group consisting of a polylactide, a polyglycolide, a polycaprolactone, a polydioxanone, a polycarbonate, a polyhydroxybutyrate, a polyalkylene oxalate, a polyanhydride, a polyamide, a polyesteramide, a polyurethane, a polyacetal, a polyorthocarbonate, a polyphosphazene, a polyhydroxyvalerate, a polyalkylene succinate, and a polyorthoester, and copolymers, block copolymers, branched copolymers, terpolymers and combinations and mixtures thereof; (b) a pharmaceutically acceptable organic solvent which solubilizes the biodegradable polymer; and (c) a therapeutic polypeptide conjugated with one or more amphiphilic moieties, wherein the composition is in the form of an injectable viscous liquid and is capable of forming a controlled release implant by dissipation or dispersion of the organic solvent within a subject's body; and wherein the composition has a higher in vitro stability and a lower initial burst release than the composition would were the therapeutic polypeptide not conjugated to the amphiphilic moieties.