Patent ID: 6777422
Filing Date: 2004-08-17
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: x is 1, 2 or 3; R represents from 0 to 4 substituents independently chosen from halogen, hydroxy, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, cyano, amino, nitro, â€”COOH, carboxamide, optionally substituted mono- and di-alkyl amino, optionally substituted haloalkyl, and optionally substituted haloalkoxy; R1 is selected from alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, heteroaryl, (aryl)alkyl, (heteroaryl)alkyl, and indanyl, each of which is optionally substituted; R2, R3 and each occurrence of R4 are independently selected from hydrogen, halogen, optionally substituted alkyl, and optionally substituted alkoxy; R5 and R6 are independently selected from (i) hydrogen, halogen, hydroxy, amino, and cyano; and (ii) alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, and mono- and di-(alkyl)amino, each of which is optionally substituted; R7 is: (a) (i) hydrogen; or (ii) alkyl, alkenyl, alkynyl, alkoxy or arylalkyl, each of which is optionally substituted; and Ar1 is: (i) phenyl, naphthyl, biphenyl, or heterocycle, each of which is optionally substituted; or (ii) optionally substituted phenyl fused to a 5- to 7-membered saturated or partially unsaturated ring having from 5 to 7 ring atoms, with 0, 1, or 2 ring atoms independently chosen from N, O and S, and with remaining ring atoms being carbon; or (b) taken together with Ar1 and the carbon atom to which R7 and Ar1 are attached to form an optionally substituted group of the formula: â€ƒwherein p is an integer from 1 to about 3; and Ar2 is (i) optionally substituted aryl or (ii) optionally substituted heteroaryl having 5 to 7 ring atoms and from 1 to 3 ring heteroatoms independently selected from N, O and S.