Patent ID: 6172062
Filing Date: 2001-01-09
Classification: A61P,C07D

Abstract:
A compound comprising Formula I: ##STR24##wherein:R.sup.1 and R.sup.2 are each independently in each occurrence hydrogen, lower alkyl, alkoxy, halogen, amino or hydroxy;X is independently in each occurrence --NH or --CH.sub.2 ;m is independently in each occurrence an integer 2, 3, or 4;Y is independently in each occurrence --SO.sub.2 ;Z is independently in each occurrence formula (A) or (B): ##STR25##wherein:R.sup.3, R.sup.4, and R.sup.5 are each independently in each occurrence hydrogen or lower alkyl;Q is independently in each occurrence O, S, --NR.sup.6, or --CR.sup.7 R.sup.8 ;n is independently in each occurrence an integer 1 or 2;wherein:R.sup.6 is independently in each occurrence hydrogen, lower alkyl, cycloalkyl, heterocyclyl, heteroaryl, --COR.sup.9, --SO.sub.2 R.sup.9, --CONR.sup.10 R.sup.11, --SO.sub.2 NR.sup.10 R.sup.11, or aryl optionally mono- or di-substituted with halogen or lower alkyl;R.sup.7 is independently in each occurrence hydrogen or lower alkyl;R.sup.8 is independently in each occurrence hydrogen, lower alkyl, alkoxy, aryloxy, --(CH.sub.2).sub.p CONR.sup.10 R.sup.11, --(CH.sub.2).sub.p SO.sub.2 NR.sup.10 R.sup.11, --(CH.sub.2).sub.p NR.sup.7 COR.sup.9, or --(CH.sub.2).sub.p NR.sup.7 SO.sub.2 R.sup.9 ; orR.sup.7 and R.sup.8 taken together with the common ring carbon to which they are attached form a monocyclic saturated 5- or 6-membered ring optionally independently containing 0 or 1 heteroatom of nitrogen, oxygen, or sulfur;wherein:p is independently in each occurrence an integer 0, 1, 2, 3 or 4;R.sup.9 is independently in each occurrence lower alkyl, heteroaryl, heterocyclyl, or aryl optionally mono- or di-substituted with halogen or lower alkyl; andR.sup.10 and R.sup.11 are each independently hydrogen or lower alkyl;or an individual isomer, a racemic or non-racemic mixture of isomers, or apharmaceutically acceptable salt or hydrate thereof.