Patent ID: 6831090
Filing Date: 2004-12-14
Classification: A61K,A61P,C07D

Abstract:
A method of treating breast cancer, ovarian cancer, colon cancer, head a d neck cancer, lung cancer, cervical cancer, uterine cancer, rain cancer, germ cell cancer, urothelial cancer, esophageal cancer, prostrate cancer , bladder cancer, or pancreatic cancer in a patient in need of said treatment which comprises administering to said patient a therapeutically effective amount of a compound of formula: wherein:Q is selected from the group consisting of: G is selected from the group consisting of: alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, W is O; X is O; S; or H, H; Y is selected from the group consisting of: O; NOR15; CHR19; H and H; H and OR13; OR14 an OR14; H and NR17R18; and H and NHOR16, wherein when Y is OR14, OR14 the R14 groups can be joined to form a cyclic ketal; B is selected from the group consisting of: H, OR20, OCOR21, and NR22R23; D is NR24R25 or saturated heterocyclo; each R1, R2, R3, and R4 is, independently, H or lower alkyl; each R15, R16, R17, R18, and R19 is, independently, selected from the group consisting of: H alkyl, substituted alkyl, and aryl; each R6, R7, R13, R14, R20 and R21 is, independently, selected from the group consisting of: H alkyl and substituted alkyl; each R5, R9, R10, R11, R22, R24, R26 and R27 is, independently, selected from the group consisting of: H, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl and heterocyclo; R8 is selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, and heterocyclo; each R23 and R25 is, independently, selected from the group consisting of: H, alkyl, substitute alkyl, aryl, heteroaryl, cycloalkyl, heterocyclo, R26C&boxH;O, R27SO2, hydroxy, O-alky and O-substituted alkyl; or pharmceutically acceptable salts, hydrates, solvates, or stereoisomers thereof, with the proviso that compounds of the Formula (I) do not include compounds wherein each of: X is O; R1, R2, R3, R4 are methyl; R5 is H or methyl; and G is 1-methyl-2-(2-methyl-4-thiazolyl)ethenyl.