Patent ID: 7070793
Filing Date: 2006-07-04
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An isolated antigenic polypeptide which is recognized by an antiserum from a mammal having resistance to Candida albicans infection, wherein said antigenic polypeptide is: (A) a polypeptide having the amino acid sequence of SEQ ID NO: 1; (B) a polypeptide encoded by a nucleic acid having the nucleotide sequence of SEQ ID NO: 10; or (C) a polypeptide encoded by a nucleic acid capable of hybridizing with a nucleic acid which encodes a polypeptide having the amino acid sequence of SEQ ID NO: 1, or a nucleic acid having the nucleotide sequence of SEQ ID NO: 10, or a nucleic acid fully complementary thereto, under stringent conditions which include incubation at 50° C. for 12 to 20 hours together with a nucleic acid probe in 6×SSC, wherein 1×SSC has 0.15M NaCl, 0.015M sodium citrate and a pH of 7.0 and contains 0.5% by weight of SDS, 0.1% by weight of bovine serum albumin, 0.1% by weight polyvinyl pyrrolidone, 0.1% by weight of a synthetic, water soluble, nonionic copolymer of sucrose and epichlorhydrin having a molecular weight of about 400,000, and 0.01% by weight of denatured salmon sperm DNA.