Patent ID: 6831058
Filing Date: 2004-12-14
Classification: A61K,A61P,Y10S

Abstract:
A method of treating a fracture comprising administering to an animal in need of same a therapeutically effective, fracture treating amount of basic fibroblast growth factor impregnated in a water insoluble, in vivo degradable cross-linked gelatin gel for sustained release of the basic fibroblast growth factor, the cross-linked gelatin gel having a water content of 63.1 to 99% w/w and produced by process comprising the steps of:(a) cross-linking an alkali-treated gelatin having an isoelectric point of 4.9 to provide a cross-linked, water-insoluble gelatin gel; (b) lyophilizing or drying the cross-linked, water-insoluble gelatin gel of step (a); and (c) incorporating basic fibroblast growth factor into the cross-linked, water-insoluble gelatin gel of step (b).