Patent ID: 6080875
Filing Date: 2000-06-27
Classification: C07D

Abstract:
Process for the preparation of 2-thienylethylamine derivatives of general formula: ##STR8## as well as their acid addition salts, in which R represents a halogen atom and R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group wherein a thienylglycidic derivative of general formula: ##STR9## in which M represents an alkali metal atom or a fraction of an alkaline-earth metal atom, is reacted with a phenylglycine ester, optionally in the form of a strong acid salt, of general formula: ##STR10## in which R and R.sub.1 have the same meaning as above, in the presence of an alkali metal borohydride of general formula:X--Y IVin which X represents an alkali metal atom and Y represents a group of formula:--BH.sub.3 CN or --BH.sub.(4-w) Z.sub.win which Z represents a carboxylic acid residue and w represents 1, 2 or 3, which gives the desired compound in the form of a free base which can be treated, if necessary, with an acid in order to obtain an addition salt of this compound.