Patent ID: 8598165
Filing Date: 2013-12-03
Classification: A61K,A61P,C07D

Abstract:
1. A method for inhibiting activity of cytochrome P450 2A13 in a subject comprising administering to a subject who is a smoker or who has been exposed to second hand smoke a therapeutically effective amount of a morpholine compound so as to inhibit activity of cytochrome P450 2A13 and the subsequent formation of cancerous metabolites of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450 2A13, wherein said morpholine compound comprises 4-(2-chlorobenzyl)morpholine, 4-(2-chloro-6-fluorobenzyl) morpholine, 4-(2-methylbenzyl)morpholine, 4-(2-bromobenzyl)morpholine, 4-(2-chlorobenzyl) thiomorpholine, 4-(2,3-dichlorobenzyl) morpholine, 4-(2,6-dichlorobenzyl) morpholine, or 4-(2,4-dichlorobenzyl) morpholine.