Patent ID: 6603009
Filing Date: 2003-08-05
Classification: A61P,C07C,C07D

Abstract:
A process for oxidizing a 2-(2-pyridinylmethyl-thio)benzimidazol compound of formula I to a compound of formula II, comprising carrying out said oxidation in the presence of sodium percarbonate and a molybdenum salt catalyst according to the following reaction: whereinR1 is selected from the group consisting of an alkyl group with 1 to 6 carbon atoms, a halogenated alkyl group with 1 to 6 carbon atoms, and a â€”(CH2)nâ€”OR9 group, wherein n is an integer from 1 to 6, and R9 represents hydrogen or an alkyl group with 1 to 6 carbon atoms; R2, R3, R4, R5, R6 and R8, independently from each other are selected from the group consisting of hydrogen, an alkyl group with 1 to 6 carbon atoms, and an alkoxy group with 1 to 6 carbon atoms; and R7 is selected from the group consisting of hydrogen, an alkyl group with 1 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms, and a fluorinated alkoxy group with 1 to 6 carbon atoms.