Patent ID: 6118025
Filing Date: 2000-09-12
Classification: C07B,C07C

Abstract:
A method of preparing an optically active alcohol of formula (I): ##STR6## in which the carbon atom indicated by the symbol * can have the (R) or (S) configuration and X represents a non-substituted amino group or a mono- or di-(C.sub.1 -C.sub.4)alkylamino group, which are optionally salified, wherein:a/ a ketone of formula (II): ##STR7## in which X is as defined above, is subjected to a catalytic hydrogenation in the presence of a rhodium complex of formula (III):[Rh(AMPP)(1,5COD)].sup.+ A.sup.- (III)in which (AMPP) represents a chiral aminophosphine-phosphinite of formula (IV): ##STR8## wherein the carbon atom indicated by the symbol * can have the (R) or (S) configuration, R and R' independently represent a cyclohexyl or a cyclopentyl and (1,5-COD) represents 1,5-cyclooctadiene and A.sup.- represents a sterically hindered and little-co-ordinating monovalent anion; andb/ the optically active alcohol of formula (I) is isolated.