Patent ID: 7015016
Filing Date: 2006-03-21
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method for inducing a mucosal immunity with production of secretory IgA antibodies that neutralize or block a native Tat protein originating from cancerous cells, from cells infected by an HIV virus or from an immune system cell, said native Tat protein being locally immunosuppressive and/or angiogenic and said method comprising administering to a patient in need thereof, by the mucous membrane route, a pharmaceutical composition comprising: (i) an active compound selected from the group consisting of: said immunosuppressive and/or angiogenic native Tat protein, the properties of which have been inactivated by at least 70% by a physical and/or a chemical treatment, by genetic recombinant or also by adjuvant conditioning; an inactive fragment of said immunosuppressive and/or angiogenic native Tat protein; a DNA molecule encoding said immunosuppressive and/or angiogenic native Tat protein inactivated by at least 70% by mutation; and a DNA molecule encoding an inactive fragment of said immunosuppressive and/or angiogenic native Tat protein; and (ii) an adjuvant of mucosal immunity.