Patent ID: 6124102
Filing Date: 2000-09-26
Classification: B01J,B82Y,C07B,C07C,C07D,C07H,C07K,C12Q,C40B,G01N,G03F,G11C,Y02P,Y10S

Abstract:
A method of determining the tendency of a receptor to bind to a ligand comprising:(a) exposing a labelled receptor to a substrate, said substrate comprising a plurality of ligands at known locations;(b) at a plurality of pixels within each of the known locations, determining an intensity value for the amount of signal generated from within each pixel; and(c) for each known location, identifying a subset of pixels that fall within a statistical norm of intensity values for all pixels within the known location; and(d) determining relative binding of the receptor to the ligands from the subset of pixelswherein steps (b)-(d) are performed by a digital computer.