Patent ID: 8071321
Filing Date: 2011-12-06
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating a melanoma comprising administering to a subject with a melanoma an amount of interferon-β (IFN-β) receptor agonist to up-regulate expression of a tumor associated antigen (TAA) on the melanoma followed by administering an autologous immune cell that interacts with a melanoma cell of the melanoma, wherein the IFN-β receptor agonist comprises a polypeptide comprising the amino acid sequence of SEQ ID NO: 29 or SEQ ID NO: 30, and wherein the TAA is selected from the group consisting of Melan-A/MART-1, gp100, tyrosinase, NY-ESO-1, MAGE, MITF, and SOX-10, thereby treating the melanoma.