Patent ID: 8470992
Filing Date: 2013-06-25
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. An isolated polynucleotide encoding a monoclonal antibody which binds to an extracellular domain of human ILT7 or a fragment comprising its antigen binding region wherein the monoclonal antibody comprises an amino acid sequence selected from any of the following combinations (a) to (c) as the heavy chain variable region and the light chain variable region: a) a heavy chain variable region of SEQ ID NO: 39 and a light chain variable region of SEQ ID NO: 41; b) a heavy chain variable region of SEQ ID NO: 43 and a light chain variable region of SEQ ID NO: 45; and c) a heavy chain variable region of SEQ ID NO: 47 and a light chain variable region of SEQ ID NO: 49.