Patent ID: 6403789
Filing Date: 2002-06-11
Classification: C07B,C07C

Abstract:
A method of halogenating a hydroxyl group comprising reacting in an organic solvent at least one halogenating agent selected from the group consisting of a halogenating agent of the formula (1) and a halogenating agent of the formula (4), and at least one compound selected from the group consisting of lower alkyl sulfone, lower alkenyl sulfone, aryl sulfone and heterocyclic sulfone at the same time, with a hydroxyl group containing compound of the formula (2) to obtain a halogenide of the formula (3) wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine atom; and Y is chlorine ion, bromine ion, dichlorophosphate ion, dibromophosphate ion, chlorosulfonate ion, bromosulfonate ion, chlorooxalate ion or bromooxalate ion; A-OHâ€ƒâ€ƒ(2) wherein A is a straight-chain or branched-chain alkyl group which may be substituted, a straight-chain or branched-chain alkenyl group which may be substituted, a monocyclic or polycyclic aromatic residue which may be substituted, a steroid residue, or a monocyclic or polycyclic heterocyclic residue which may be substituted; A-Xâ€ƒâ€ƒ(3) wherein A and X are the same as above; wherein R1 and R4 are methyl or phenyl; and X and Y are the same as above.