Patent ID: 8735096
Filing Date: 2014-05-27
Classification: C07K,C12N,C12Q

Abstract:
1. A fusion protein comprising at least two photochromic polypeptides connected to a selected polypeptide of interest, wherein a first photochromic polypeptide is connected to the N-terminus of the selected polypeptide of interest and a second photochromic polypeptide is connected to the C-terminus of the selected polypeptide of interest, wherein the oligomerization state of the first photochromic polypeptide and the second photochromic polypeptide is controllable with light, wherein at least one photochromic polypeptide is a Dronpa polypeptide comprising an amino acid substitution at position 145 or a Padron polypeptide comprising an amino acid substitution at position 145, wherein the amino acid substitution at position 145 confers oligomerization characteristics, such that the first photochromic polypeptide and the second photochromic polypeptide are capable of associating with each other.