Patent ID: 6663863
Filing Date: 2003-12-16
Classification: A61K,A61M,A61P,C07K

Abstract:
A method of inhibiting stenosis or restenosis of a blood vessel following a vascular intervention procedure which includes the placement of a stent in a subject, comprising administering to said subject a therapeutically effective amount of a first therapeutic agent and a therapeutically effective amount of a second therapeutic agent, whereinsaid first therapeutic agent is an anti-CD18 antibody or antigen-binding fragment thereof which binds CD18 and inhibits binding of a ligand to an integrin which contains CD18, wherein said anti-CD18 antibody or antigen-binding fragment comprises light chain complementarity determining regions (CDR1, CDR2 and CDR3) of nonhuman origin, heavy chain complementarity determining regions (CDR1, CDR2 and CDR3) of nonhuman origin, and at least a portion of an immunoglobulin of human origin, wherein said light chain complementarity determining regions and said heavy chain complementarity determining regions have the amino acid sequences set forth below: light chain: CDR1: the amino acid sequence of SEQ ID NO:2 CDR2: the amino acid sequence of SEQ ID NO:3 CDR3: the amino acid sequence of SEQ ID NO:4 heavy chain: CDR1: the amino acid sequence of SEQ ID NO:6 CDR2: the amino acid sequence of SEQ ID NO:7 CDR3: the amino acid sequence of SEQ ID NO:8; and said second therapeutic agent is an anti-CCR2 antibody or antigen-binding fragment thereof which binds CCR2 and inhibits binding of a ligand to said CCR2, wherein said anti-CCR2 antibody or antigen-binding fragment comprises light chain complementarity determining regions (CDR1, CDR2 and CDR3) of nonhuman origin, heavy chain complementarity determining regions (CDR1, CDR2 and CDR3) of nonhuman origin, and at least a portion of an immunoglobulin of human origin, wherein said light chain complementarity determining regions and said heavy chain complementarity determining regions have the amino acid sequences set forth below: light chain: CDR1: the sequence of amino acids 24-39 of SEQ ID NO:11 CDR2: the sequence of amino acids 55-61 of SEQ ID NO:11 CDR3: the sequence of amino acids 94-102 of SEQ ID NO:11 heavy chain: CDR1: the sequence of amino acids 31-35 of SEQ ID NO:12 CDR2: the sequence of amino acids 50-68 of SEQ ID NO:12 CDR3: the sequence of amino acids 101-106 of SEQ ID NO:12.