Patent ID: 7132243
Filing Date: 2006-11-07
Classification: C12N,G01N

Abstract:
1. A process for clonally expanding CD4 + memory T cells of unknown specificity for particular antigens, which comprises the steps of: obtaining CD4 co-culturing said CD4 (ii) interleukin, wherein said interleukin comprises IL-2, a combination of IL-4, IL-7, IL-9 and IL-15, or a combination of IL-2, IL-4, IL-7, IL-9 and IL-15, (iii) major histocompatibility complex (MHC) class II antigen-expressing cells with DNA synthesis being suspended, wherein said MHC class II antigen-expressing cells are also derived from the subject, and (iv) in the presence of anti-CD29 antibody having an agonist activity; so as to clonally expand said CD4