Patent ID: 8735102
Filing Date: 2014-05-27
Classification: C08B,C12N,C12P

Abstract:
1. A recombinant method for producing hyaluronic acid (HA), the method comprising the steps of: obtaining a recombinant host cell capable of producing HA, the recombinant host cell containing a recombinant expression vector comprising a nucleic acid segment encoding an enzymatically active hyaluronan synthase, wherein the enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA (uridine diphosphate glucuronic acid) and UDP-GIcNAc (uridine diphosphate N-acetylglucosamine) to synthesize HA, and wherein the nucleic acid segment comprises at least one of: culturing the recombinant host cell under conditions appropriate for the expression of hyaluronan synthase from the at least one expression construct, whereby hyaluronic acid is produced.