Patent ID: 8759290
Filing Date: 2014-06-24
Classification: A61K,C07K

Abstract:
1. A metabolic compound conjugate comprising: (a) a metabolically active peptide GLP-1 agonist selected from the group consisting of GLP-1, and exenatide, wherein the metabolically active peptide GLP-1 agonist comprises: (b) an amphiphilic oligomer attached to the at least one oligomer conjugation site, wherein the oligomer has a formula: wherein m is 2-10; and n is 2-16; and, X is —C—, —O—, —C(O)—, —NH—, —NHC(O)—, or —C(O)NH—; and Y is lower alkyl or —H, wherein when the metabolically active peptide GLP-1 agonist is exenatide the oligomer is conjugated as a monoconjugate at the N-terminus, Lys 12 , or Lys 27 , or di-conjugates at N-terminus/Lys 12 , Lys 12 /Lys 27 or N-terminus/Lys 27 , and wherein when the metabolically active peptide GLP-1 agonist is GLP-1 comprising SEQ ID NO: 1 or SEQ ID NO: 2, the oligomer is conjugated as a monoconjugate at the N-terminus, Lys 20 , or Lys 28 , or di-conjugates at N-terminus/Lys 20 , Lys 20 /Lys 28 or N-terminus/Lys 28 .