Patent ID: 6143314
Filing Date: 2000-11-07
Classification: A61K

Abstract:
A polymeric composition for forming a controlled release implant within a body, comprising:about 10 wt % to about 80 wt % of a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;a biocompatible, organic solvent that is soluble to dispersible in aqueous or body fluid;about 1 wt % to about 50 wt % of a thermoplastic polymer of polylactide-glycolide moieties and polyethylene glycol moieties as a polymeric controlled release additive; anda biologically active agent,wherein the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body, and the biologically active agent is not covalently bound to the thermoplastic base polymer or the polymeric controlled release additive.