Patent ID: 6133279
Filing Date: 2000-10-17
Classification: A61K,C07D

Abstract:
A method for the treatment of renal diseases comprising administering to a patient in need thereof an effective amount for said treatment of a therapeutic agent for renal diseases containing a compound represented by the general formula (1): ##STR54## wherein X represents an oxygen atom or a group represented by the general formula (2): ##STR55## where n represents an integer from 0 to 2, R.sub.1 represents a hydrogen atom or an acyl group,R.sub.2 represents a hydrogen atom, a lower alkyl group or a lower alkenyl group,R.sub.3 represents a lower alkyl group,R.sub.4, R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group or an optionally substituted aryl group, or R.sub.6 further represents a formyl group, a carboxyl group, a lower alkoxycarbonyl group or an optionally substituted carbamoyl group, orR.sub.3 and R.sub.4 may be taken together to form a five-membered ring, orR.sub.5 and R.sub.6 may be taken together to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms, sulfur atoms or alkyl-substituted nitrogen atoms,provided than when the five-membered ring formed by R.sub.3 and R.sub.4 and the benzene ring taken together to form benzofuran, benzo[b]thiophene, benzo[b]thiophene-1-oxide or benzo[b]thiophene-1,1-dioxide, R.sub.6 is absent, or an optically active isomer or a pharmaceutically acceptable salt thereof as an active ingredient.