Patent ID: 6462046
Filing Date: 2002-10-08
Classification: C07D

Abstract:
A compound having the structure according to Formula (I) and pharmaceutically acceptable salts thereof, wherein the broken line represents an optional double bond; WhereinX is H, O, S; A is â€”C(O)â€”, â€”S(O)mâ€”; B is O, S, NR6, wherein R6 is H, C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl and C3-C6 cycloalkyl; n is 0 or 1; m is 1 or 2; G is C3-C10 cycloalkyl, C4-C10 cycloalkenyl, saturated C3-C10 heterocyclyl, C3-C10 cycloalkyl-C1-C3 alkyl, C4-C10 cycloalkenyl-C1-C3 alkyl, saturated C3-C10 heterocyclyl-C1-C3 alkyl, said cycloalkyl, cycloalkenyl, heterocyclyl and alkyl optionally substituted with 1 to 3 groups of Rs, wherein heterocyclyl contains 1 to 4 heteroatoms which may be nitrogen, sulfur or oxygen atom; R1 is hydrogen, hydroxy, thio, nitro, cyano, azido, amino, trifluoromethyl, trifluoromethoxy, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 alkylthio, C1-C6 alkylamino, C1-C6 alkenyl, C1-C6 alkenyloxy, C1-C6 alkenylamino, C3-C8 cycloalkyl, C3-C8 cycloalkyloxy, C3-C8 cycloalkylamino, C3-C8 cycloalkylthio, C1-C6 alkylcarbonylamino, C3-C8 cycloalkylcarbonylamino, C5-C10 aryl, C5-C10 heteroaryl or C5-C10 saturated heteroaryl; said aryl, heteroaryl, alkyl, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of Rs; R2, R3, and R5 independently are H, trifluoromethyl, C5-C10 aryl, C5-C10 heteroaryl, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, saturated C5-C10 heteroaryl, C5-C10 aryl-C1-C10 alkyl, C5-C10 heteroaryl-C1-C10 alkyl, COR7, CO2R7, CONR7R8, SO2NR7R8, said aryl, heteroaryl, alkyl, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of Rs; R4 is selected from the group consisting of trifluoromethyl, C5-C10 aryl, C5-C10 heteroaryl, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, saturated C5-C10 heteroaryl, C5-C10 aryl-C1-C10 alkyl, C5-C10 heteroaryl-C1-C10 alkyl, COR7, CO2R7, CONR7R8, SO2NR7R8, said aryl, heteroaryl, alkyl, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of Rs; R7 and R8 independently are H, hydroxy, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 aryl, C5-C10 heteroaryl, said aryl, heteroaryl, alkyl, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of Rs; Rs represents a member selected from the group consisting of halo, cyano, nitro, trihalomethyl, carbamoyl, hydroxy, OCF3, acyl, aryl, heteroaryl, S(O)R8, &boxH;N(OR8), SO2R8, COOR8, â€”CONR7R8, â€”C1-C6alkylCONR7R8, C1-C6alkyloxy, aryloxy, arylC1-C6alkyloxy, thio, C1-C6alkylthio, arylthio, arylC1-C6alkylthio, NR7R8, C1-C6alkylamino, arylamino, arylC1-C6alkylamino, di(arylC1-C6alkyl)amino, C1-C6alkylcarbonyl, arylC1-C6alkylcarbonyl, C1-C6alkylcarboxy, arylC1-C6alkylcarboxy, â€”NR7CO2R8, â€”NR7COR8, â€”NR7CO2R8, â€”NR7SO2R8, â€”CONR7R8, â€”SO2NR7R8, â€”OCONR7R8, â€”C1-C6alkylaminoCONR7R7R8, arylC1-C6alkylcarbonylamino, tetrahydrofuryl, morpholinyl, piperazinyl, or a saturated or partial saturated cyclic 5,6 or 7 membered amine or lactam; said aryl, land heteroaryl optionally substituted with 1 to 3 groups of halo or C1-C6alkyl; wherein R7 and R8 are defined as above.