Patent ID: 8129368
Filing Date: 2012-03-06
Classification: A61P,C07D

Abstract:
1. A compound selected from (1R,2S,7R,8S)—N-{3-[3-(2-Chloro-4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(1S,2S,7R,8R)-3-(3-Chloro-4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(2S,7R)-6-Hydroxy-3-(3-methoxy-benzyl)-4-oxo-3-aza-tricyclo [6.2.2.0 N-{3-[(2S,7R)-3-(2,4-Difluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo [6.2.2.0 N-{3-[(2S,7R)-3-(2-Chloro-4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza- tricyclo[6.2.2.0 N-{3-[(2S,7R)-3-(2-Bromo-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo [6.2.2.0 N-{3-[(2S,7R)-3-(4-Fluoro-3-methoxy-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-3-(3-Chloro-4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-3-(3,3 -Dimethyl-butyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-3-(3,4-Difluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-3-(4-Fluoro-3-methyl-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[2S,7R)-3-Benzyl-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 (rac-di-exo, di-exo)-N-{3-[3-(4-Fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tetracyclo[6.3.1.0 N-{3-[(2S,7R)-3-(3-Fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo [6.2.2.0 N-{3-[(2S,7R)-3-Cyclohexylmethyl-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-6-Hydroxy-4-oxo-3-thiophen-2-ylmethyl-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-6-Hydroxy-3-(2-methyl-benzyl)-4-oxo-3-aza-tricyclo[6.2.2.0 N-{3-[(2S,7R)-6-Hydroxy-4-oxo-3-(2,3,4-trifluoro-benzyl)-3-aza-tricyclo[6.2.2.0 N-{3-[(1S,2S,7R,8R)-3-(4-Fluoro-3-methyl-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(1S,2S,7R,8R)-(3-Benzyl-6-hydroxy-4-oxo-3-aza-tricyclo [6.2.1.0 N-{3-[(1R,2S,7R,8S)-3-(3-Fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(1 S,2S,7R,8R)-6-Hydroxy-4-oxo-3-(1 -trifluoromethyl-cyclopropylmethyl)-3-aza-tricyclo[6.2.1.0 N-{3-[(1S,2S,7R,8R)-3-(3,4-Difluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(1R,2S,7R,8S)-6-Hydroxy-4-oxo-3-(2,3,4-trifluoro-benzyl)-3-aza-tricyclo[6.2.1.0 N-{3-[(1R,2S,7R,8S)-6-Hydroxy-4-oxo-3-thiophen-3-ylmethyl-3-aza-tricyclo[6.2.1.0 N-{3-[(2S,7R)-6-Hydroxy-4-oxo-3-(2,4,5-trifluoro-benzyl)-3-aza-tricyclo[6.2.2.0 N-{3-[(1R,2S,7R,8S)-6-Hydroxy-4-oxo-3-thiophen-2-ylmethyl-3-aza-tricyclo [6.2. 1 .0 N-{3-[(1R,2S,7R,8S)-(3-Cyclohexylmethyl-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 N-{3-[(1 S,2S,7R,8R)-6-Hydroxy-3-(2-methyl-benzyl)-4-oxo-3-aza-tricyclo [6.2.1.0 N-{3-[(1S,2S,7R,8R)-3-(3-Fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0 or pharmaceutically acceptable salts thereof.