Patent ID: 6599903
Filing Date: 2003-07-29
Classification: C07D

Abstract:
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of R1 and R2 are individually selected from the group consisting of hydrogen, halogen, â€”OH and alkyl and alkoxy of 1 to 6 carbon atoms, R3 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and â€”COR4, R4 is alkyl of 1 to 6 atoms, R5 is selected from the group consisting of hydrogen, â€”OH and alkyl and alkoxy of 1 to 6 carbon atoms, X is selected from the group consisting of â€”Z1â€”, â€”Z1â€”COâ€”, â€”CH&boxH;, â€”CH&boxH;CHâ€”COâ€”, â€”Z1â€”NR3â€”COâ€”Zâ€²1â€”, â€”COâ€”NR3â€”Zâ€²1â€”, â€”Z1â€”NR3â€”CSâ€”, â€”Z1â€”NR3â€”SO2â€” and a single bond, Het is piperazine or 1,4-diazepine unsubstituted or substituted by at least one member of the group consisting of â€”X1â€”OR3, â€”X1â€”NR3 and â€”X1â€”Sâ€”R3, Y is selected from the group consisting of â€”Z2â€”Qâ€”, â€”Z2â€”COâ€”, â€”Z2â€”NHâ€”COâ€”, â€”Z2â€”CH2â€”NR3â€”COâ€”, â€”NR3â€”Z2â€”Qâ€”, â€”NR3â€”COâ€”Z2â€”Qâ€”, â€”NR3â€”NHâ€”COâ€”Z2, â€”NHâ€”NHâ€”Z2â€”, â€”NR3â€”Oâ€”Z2â€”, NR3â€”SO2â€”NR3â€”Z2â€”, â€”Oâ€”Z2â€”Q, â€”Oâ€”COâ€”Z2â€”Q and â€”Sâ€”Z2â€”Qâ€”, Q is selected from the group consisting of â€”Sâ€”Z3 and a single bond, and X1 is â€”(CH2)nâ€”, n is an integer from 0 to 6, Z1, Zâ€²1, Z2 and Z3 are individually a single bond or alkyl of 1 to 6 carbon atoms, R6 is hydrogen or â€”OH, W is â€”NH2 or â€”NO2 and a salt thereof.