Patent ID: 8124752
Filing Date: 2012-02-28
Classification: C12N

Abstract:
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human MYC gene, wherein said dsRNA comprises a sense strand and an antisense strand, wherein the sense strand consists of the nucleotide sequence of SEQ ID NO:11 and the antisense strand consists of the nucleotide sequence of SEQ ID NO:12 and each strand is modified as follows to include a 2′-O-methyl ribonucleotide as indicated by a lower case letter “c” or “u” and a phosphorothioate as indicated by a lower case letter “s”: SEQ ID NO:11 is cGAcGAGAAcAGuuGAAAcTsT and SEQ ID NO:12 is GUUUcAACUGUUCUCGUCGTsT.