Patent ID: 6290953
Filing Date: 2001-09-18
Classification: A61K,A61P,C12N

Abstract:
A method of modulating cellular proliferation in a mammal in need thereof which comprises administering to said mammal an amount of a pharmaceutical composition effective to modulate cellular proliferation, said composition comprising a pharmaceutically acceptable vehicle and a non-human thymidine phosphorylase polypeptide characterized by having a thymidine phosphorylase activity at least about 5% of native E. coli thymidine phosphorylase, wherein said activity is determined as the V.sub.max (.mu.moles min.sup.-1 mg.sup.-1) of the enzyme at 25.degree. C. in the presence of 1 mM thymidine in 0.2M KH.sub.2 PO.sub.4 at pH 7.4.