Patent ID: 6395784
Filing Date: 2002-05-28
Classification: A61K,A61P,C07C

Abstract:
A compound of the formula whereinX is oxygen (â€”Oâ€”), sulfur (â€”Sâ€”), carbonyl (â€”COâ€”), methylene (â€”CH2â€”), or disubstituted nitrogen (â€”NHâ€”); R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R2 and R3 being other than hydrogen; R4 is methyl, ethyl, n-propyl or trifluoromethyl; R5 is hydrogen or lower alkyl; R6 is carboxylic acid, or ester thereof, or a prodrug thereof; R7 is hydrogen, or an alkanoyl or aroyl group, or other group capable of bioconversion to generate the free phenol structure (wherein R7=H); including all stereoisomers thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof.