Patent ID: 8741838
Filing Date: 2014-06-03
Classification: A01K,A61K,A61P,C07K

Abstract:
1. A method for cytoprotection of epithelial cells injured in vivo in kidney tissues, the method comprising: (a) obtaining a composition selected from the group consisting of a gastrokine protein and a biologically active peptide, wherein the gastrokine protein is an AMP-18 protein consisting of amino acid residues 21-185 of sequence SEQ ID NO: 3 and the biologically active peptide is selected from the group consisting of amino acids consisting of positions 97-117 of SEQ ID No: 3, amino acids consisting of positions 78-119 of SEQ ID No: 3, amino acids consisting of positions 97-121 of SEQ ID NO:3, amino acids consisting of positions 104-111 of SEQ ID NO: 3, and amino acids consisting of positions 104-117 of SEQ ID NO: 3; and (b) administering the composition to the injured epithelial cells in vivo to protect the cells from cell death.