Patent ID: 6147211
Filing Date: 2000-11-14
Classification: A61P,C07F,C07H

Abstract:
A method for enzymatically treating a compound comprising the step of:treating a compound of Formula (I) ##STR5## with a biocatalyst having cyclic phosphodiesterase activity wherein R is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2 or --CH.sub.2 CH.sub.2 X, and wherein R.sup.1 is hydrogen or (C.sub.1 -C.sub.6) alkyl, n is a number form 1 to 6, X is OH, F, NR.sup.3 R.sup.4, and R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -C.sub.6) alkyl;B is adenine, guanine or hypoxanthine; and,Z is hydrogen or a negative charge,Wherein the source of the biocatalyst having cyclic phosphodiesterase activity is a gram-negative bacterium.