Patent ID: 8569348
Filing Date: 2013-10-29
Classification: A61K,A61P,C07D

Abstract:
1. A method for rebducing and/or delaying metastasis in a subject, comprising contacting the subject with an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted C iv) substituted or unsubstituted C v) substituted or unsubstituted C vi) substituted or unsubstituted C vii) substituted or unsubstituted C viii) R Z is a unit having the formula: R i) hydrogen; ii) hydroxyl; iii) amino; iv) substituted or unsubstituted C v) substituted or unsubstituted C vi) substituted or unsubstituted C vii) substituted or unsubstituted C viii) substituted or unsubstituted C L is a linking unit having the formula: Q and Q i) —C(O)—; ii) —NH—; iii) —C(O)NH—; iv) —NHC(O)—; v) —NHC(O)NH—; vi) —NHC(O)O—; vii) —C(O)O—; viii) —C(O)NHC(O)—; ix) —O—; x) —S—; xi) —SO xii) —C(═NH)—; xiii) —C(═NH)NH—; xiv) —NHC(═NH)—; or xv) —NHC(═NH)NH—; R i) hydrogen; ii) hydroxy; iii) halogen; iv) C v) a unit having the formula: R i) hydrogen; or ii) substituted or unsubstituted C R i) hydrogen; ii) substituted or unsubstituted C iii) substituted or unsubstituted C iv) substituted or unsubstituted C v) substituted or unsubstituted C R i) hydrogen; or ii) C the index n is 0 or 1; the indices t, w and x are each independently from 0 to 4; the indices y and z are each independently 0 or 1; or a pharmaceutically acceptable salt thereof; wherein the cancer is malignant melanoma or lung cancer.