Patent ID: 7972780
Filing Date: 2011-07-05
Classification: C12Q

Abstract:
1. A method for predicting tolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP) in a human subject having Crohn's disease or ulcerative colitis, said method comprising: (a) genotyping nucleic acid in a sample from said subject for the presence of a 94 C to A mutation in the inosine triphosphate pyrophosphatase (ITPA) coding region; (b) indicating that the presence of said mutation is predictive of decreased tolerance to AZA or 6-MP; and (c) predicting the subject with said mutation has increased risk of flu-like symptoms relative to a subject without said mutation and predicting the subject with said mutation does not have increased risk of myelosuppression relative to a subject without said mutation.