Patent ID: 8603752
Filing Date: 2013-12-10
Classification: G01N

Abstract:
1. A method for determining the presence or absence of a drug side effect in a subject taking a drug for which a first organ is expected to be the therapeutic target wherein said side effect is associated with a second organ different from said first organ and wherein said second organ is not the therapeutic target of the drug comprising, (a) detecting a level of each of a plurality of organ-specific proteins in a test blood sample from the subject, wherein the plurality of organ-specific proteins are secreted from said second organ; (b) comparing said level of each of the plurality of said organ-specific proteins in said test blood sample to a level of each of the plurality of said organ-specific proteins in a control sample of blood from one or more subjects who have not taken said drug wherein the organ-specific proteins comprises at least 5 organ-specific proteins; wherein a statistically significant altered level of one or more of the plurality of said organ-specific proteins in the test blood sample as compared to said control sample is indicative of the presence of a drug side effect in said subject.