Patent ID: 6811688
Filing Date: 2004-11-02
Classification: G01N

Abstract:
A chromatography column having a column tube and end filter arrangements which, in use, retain a bed of particulate chromatography medium in the column tube between them while allowing the passage of fluid for chromatography;at least one of the end filter arrangements being at the front end of a plunger which is axially slidable along inside the column tube, makes a seal outwardly against the tube and incorporates an internal flow conduit communicating along the plunger between a permeable filter portion of the respective end filter arrangement and a rear part of the plunger outside the column tube; the plunger comprising a tubular stem of glass or thermoplastic material which defines in one piece said internal flow conduit including an integral front divergent portion, the permeable filter portion being integrally bonded to the front end of the tubular stem across the front divergent portion of the internal flow conduit to form an internal distribution space, and an outer plunger wall spaced outwardly from said tubular stem at locations rearward of the front divergent portion of the internal flow conduit, the outer plunger wall and tubular stem being integrally bonded to one another around said tubular stem at the front divergent portion so as to seal off an internal space at the front end of the plunger.