Patent ID: 7662980
Filing Date: 2010-02-16
Classification: A61P,C07D

Abstract:
1. A process of producing crystalline N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol comprising the steps of: coupling an oxazole intermediate of formula I: with a baccatin III derivative of formula II: to produce a compound of formula III: acidifying the compound of formula III to produce a compound of formula IV: protecting the compound of formula IV to form a compound of formula V: deprotecting the compound of formula V obtain a compound of formula VI: ozonolysing the compound of formula VI to obtain a compound of formula VII: proceeding condensation of the compound of formula VII to obtain crude N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol: crystallizing the crude N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol to obtain the crystalline N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol.