Patent ID: 6833367
Filing Date: 2004-12-21
Classification: A61P,C07D

Abstract:
A compound of formula I where A is â€”CH&boxH;C(R1)CH2â€”, â€”CH2N(R2)CH2â€”, â€”CH2N(R2)C(O)â€”, â€”C(O)N(R2)CH2â€”, â€”CH2N(CO2R3)CH2â€” or â€”CH2N(COR2)CH2â€”; B is â€”CH(R1)CH&boxH;CHCH&boxH;CH2, â€”CH(R2)R1, â€”CH(R1)CH&boxH;CHR2, â€”CH(R1)CH&boxH;CHC(O)OR2, â€”CH(R1)CH&boxH;CHC(O)N(R1)R2, â€”CH(R1)CH2OR2 or Ar; C is H, â€”C(O)N(R1)R2, â€”C(O)NHCH2(CH2)nN(CH3)2, or â€”C(O)NHCH2(CH2)n-4-morpholino; R1 is H or (C1-6)alkyl; R2 is H, (C1-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, (C1-6)alkyl-Ar or Ar; R3 is (C1-6)alkyl, (C1-6)alkyl-Ar or Ar; Ar is an aromatic or heteroaromatic ring selected from R4 and R5 are, independently, H, (C1-6)alkyl, OH, O(C1-6)alkyl, OCH2(CH2)nOH, O(CH2)nCO2H, OCH2(CH2)nN(CH3)2, OCH2(CH2)n-4-morpholino, F, Cl, Br or CF3; and n is 1 or 2; with the proviso that when A is â€”CH&boxH;C(CH3)CH2â€” or â€”CH&boxH;CHCH2â€”, then either: B cannot be â€”CH(CH3)CH&boxH;CHCH&boxH;CH2, â€”CH(CH3)CH2Ph, â€”CH(CH3)Ph, â€”CH(CH3)-n-Bu, or C cannot be â€”C(O)N(R1)R2 or H; or an acid or base addition salt thereof, where possible.