Patent ID: 6284732
Filing Date: 2001-09-04
Classification: A61K,C07K

Abstract:
A compound comprising the formula:Z.sub.1 -X.sub.1 -X.sub.2 -X.sub.3 -X.sub.4 -X.sub.5 -X.sub.6 -X.sub.7 -X.sub.8 -X.sub.9 -X.sub.10 -X.sub.11 -X.sub.12 -X.sub.13 -X.sub.14 -X.sub.15 -X.sub.16 -X.sub.17 -Z.sub.2 (I)wherein:X.sub.1 is an apolar residue;X.sub.2 is a hydrophobic residue;X.sub.3 is an acidic or an aliphatic residue;X.sub.4 is a basic residue;X.sub.5 is an apolar residue;X.sub.6 is an aromatic residue;X.sub.7 is a polar residue;X.sub.8 is an aliphatic residue;X.sub.9 is an acidic or an aliphatic residue;X.sub.10 is an aromatic residue;X.sub.11 is an aromatic residue;X.sub.12 is a polar residue;X.sub.13 is Ile;X.sub.14 is an apolar residue;X.sub.15 is an acidic residue;X.sub.16 is a polar residue;X.sub.17 is a basic or an aliphatic residue;Z.sub.1 is H.sub.2 N--, RHN-- or, RRN--;Z.sub.2 is --C(O)R, --C(O)OR, --C(O)NHR, --C(O)NRR;each R is independently (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkenyl, (C.sub.1 -C.sub.6) alkynyl, substituted (C.sub.1 -C.sub.6) alkyl, substituted (C.sub.1 -C.sub.6) alkenyl or substituted (C.sub.1 -C.sub.6) alkynyl;each ""-"" between residues Z.sub.1 and X.sub.1 and residues Z.sub.2 and X.sub.17 represents a covalent linkage; andeach ""-"" between residues X.sub.1 through X.sub.17 represents a covalent linkage wherein the compound reduces cell-associated binding of transferrin as measured in an in vitro cellular binding assay and produces at least an additive effect with soluble HFE/.beta..sub.2 m heterodimers in reducing cell associated binding of transferrin as measured in the assay.