Patent ID: 6440998
Filing Date: 2002-08-27
Classification: A61K,A61P

Abstract:
A pharmaceutical composition having antitumor activity with reduced side effect(s) comprising an enhanced effective amount of a known active substance having antitumor effect selected from the group consisting of cisplatin and carboplatin or, optionally, a pharmaceutically suitable acid addition salt thereof and an effective amount of a hydroximic acid derivative of the formula I wherein,R1 represents a hydrogen atom or a C1-5 alkyl group, R2 stands for a hydrogen atom, a C1-5 alkyl group, a C3-8 cycloalkyl group or a phenyl group optionally substituted by a hydroxy or a phenyl group, or R1 and R2 together with the nitrogen atom they are attached to form a 5 to 8 membered ring optionally containing one or more further nitrogen, oxygen or sulfur atom(s) and said ring can be condensed with another alicyclic or heterocyclic ring, preferably a benzene, naphthalene, quinoline, isoquinoline, pyridine or pyrazoline ring, furthermore, optionally, the nitrogen and/or sulfur heteroatom(s) are present in the form of an oxide or dioxide, R3 means a hydrogen atom, a phenyl group, a naphthyl group or a pyridyl group wherein said groups can be substituted by one or more halo atom(s) or C1-4 alkoxy group(s), Y is a hydrogen atom, a hydroxy group, a C1-24 alkoxy group optionally substituted by an amino group, a C2-24 polyalkenyloxy group containing 1 to 6 double bond(s), a C1-25 alkanoyl group, a C3-9 alkenoyl group or a group of the formula R7â€”COOâ€” wherein R7 represents a C2-30 polyalkenyl group containing 1 to 6 double bond(s), X stands for a halo atom, an amino group, a C1-4 alkoxy group, or X forms with B an oxygen atom, or X and Y together with the carbon atoms they are attached to and the â€”NRâ€”Oâ€”CH2â€” group being between said carbon atoms form a ring of the formula a whereinZ represents an oxygen atom or a nitrogen atom, R stands for a hydrogen atom or R forms with B a chemical bond, A is a C1-4 alkylene group or a chemical bond or a group of the formula b, whereinR4 represents a hydrogen atom, a C1-5 alkyl group, a C3-8 cycloalkyl group or a phenyl group optionally substituted by a halo atom, a C1-4 alkoxy group or a C1-5 alkyl group, R5 stands for a hydrogen atom, a C1-4 alkyl group or a phenyl group, m has a value of 0, 1 or 2, n has a value of 0, 1 or 2, or a physiologically acceptable acid addition salt thereof in admixture with one or more conventional carrier(s),wherein the antitumor activity is against tumors sensitive to the combination.