Patent ID: 6599921
Filing Date: 2003-07-29
Classification: A61P,C07D

Abstract:
A compound of Formula 1 comprising A, B, C and D rings, or a pharmaceutically acceptable salt or ester thereof, wherein:i) R1 represents a substituent selected from the group consisting of: 1-pyrrolidinyl, 1-piperidinyl methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino and 1-hexamethyleneimino; ii) R2 represents a substituent selected from the group consisting of: CH2CH2CH3, CH2C(CH3)2H, CH(OH)CH2CH3, CH&boxH;CHCH3, CH&boxH;CHCH(CH3)2, CH3C&boxH;CH2, C&boxH;OCH3, C&boxH;OCH2CH3, C&boxH;OCH(CH3)2, C&boxH;OCH&boxH;CH2, C&boxH;OCH&boxH;C(CH3)H, C&boxH;OCH&boxH;C(CH3)2, C(CH3)&boxH;C(CH3)2 and CH(OH)CH3; iii) R3 is a hydrogen atom or a methyl group; iv) R4 is a hydrogen atom or a methyl group; v) R5 is a hydroxy group or an ester group represented by the formula (OC&boxH;OCH3); vi) â€œnâ€  is an integer from 1 to 4 and vii) â€œ2â€  is a carbon atom, an oxygen atom or a sulfur atom.