Patent ID: 6534499
Filing Date: 2003-03-18
Classification: A61K,A61P,C07D

Abstract:
An N-substituted-Nâ€²-substituted urea derivative represented by the following general formula I or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom, a lower alkyl group, an aryl group or a group represented by the following general formula II: wherein R2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, a carboxyl group or an ester group, or R2 may form a ring together with R1; R3 and R4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a cycloalkylalkyl group, an adamantylalkyl group, an arylalkyl group, a cycloalkyl group or an aryl group; R5 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group or an aryl group; R6 and R7 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a cycloalkylalkyl group, a cycloalkyl group or an aryl group; A1 and A2 may be the same or different and each represents a lower alkylene group, provided that R5 and either R6 or R7 together or R6 and R7 together form a 5- to 7-membered ring, wherein said 5- to 7-membered ring is not an aromatic heterocyclic ring, and that either of R3 and R4 represents a cycloalkylalkyl group, an adamantylalkyl group or an arylalkyl group.