Patent ID: 6752997
Filing Date: 2004-06-22
Classification: A61K,A61P

Abstract:
A process for preparing a pharmaceutical composition comprising as an active ingredient a hygroscopic salt of valproic acid, comprising the step of intimately mixing (i) said hygroscopic salt; (ii) a carbomer and (iii) a non-hygroscopic additive to form a homogeneous mixture; wherein the amount of said carbomer and said non-hygroscopic additive are sufficient relative to the amount of said hygroscopic salt to produce said mixture having the following property: when compressed into tablets, said tablets do not absorb more than 5% water by weight when tested after being stored for 3 months at 75% relative humidity; wherein said pharmaceutical composition is free of valproic acid; and wherein the weight ratio of carbomer to the hygroscopic salt of valproic acid ranges from about 1:3 to about 1:100.