Patent ID: 8765368
Filing Date: 2014-07-01
Classification: C12Q,G01N

Abstract:
1. A method of identifying a greater risk for developing bronchogenic carcinoma in a human subject comprising: (a) assaying a bronchial epithelial cell sample from the subject; (b) determining transcript abundance (TA) for a group of genes in the sample; wherein TA levels are determined by microarray analysis, quantitative polymerase chain reaction, or a combination of both for 7 or more genes selected from the group of genes consisting of: CEBPG, E2F1, E2F6, XRCC1, ERCC4, ERCC5, GPX1, GPX3, GSTM3, GSTP1, GSTT1, GSTZ1, MGST1, SOD1 and CAT; (c) comparing the TAs of step (b) to threshold levels for each gene, wherein the threshold levels comprise (molecules/10 (d) determining the subject as either having, or being at risk for developing, bronchogenic carcinoma when the TA levels of seven or more TAs in the test sample meet the threshold levels of step (c).