Patent ID: 8685919
Filing Date: 2014-04-01
Classification: A61K,A61P,C07K

Abstract:
1. A compound having the formula R 1 -X-Z-R 2 wherein R R X is a peptide which has the formula I: or differs from formula I at up to 4 of the following positions whereby, if different from formula I: the residue at position 2 is selected from: Aib, D-Ser; the residue at position 16 is Lys; the residue at position 17 is selected from: Arg, Leu; the residue at position 18 is Arg; the residue at position 20 is selected from: Gln, Lys, Arg; the residue at position 24 is selected from: Gln, Lys, Arg; the residue at position 27 is selected from: Met, Lys; the residue at position 28 is selected from: Asn, Leu; and the residue at position 29 is Thr; and Z is absent or a peptide sequence of 1-20 amino acid units selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr and Orn; or a pharmaceutically acceptable salt thereof.