Patent ID: 6235489
Filing Date: 2001-05-22
Classification: C12Q,G01N,Y10S

Abstract:
A method for confirming the occurrence of a hemorrhagic cerebral event or an ischemic cerebral event and distinguishing the type of event which has occurred comprising:a. analyzing a body fluid of a patient to detect the presence and concentration of four markers of cerebral events whereini. a first marker is myelin basic protein,ii. a second marker is the beta isoform of S100 protein,iii. a third marker is neuronal specific enolase,iv. a fourth marker is a brain endothelial cell membrane protein, andb. comparing said four markers to specific threshold values of each of the markers to determine the presence of statistically significant concentrations thereof of at least about two standard deviations above normal levels;wherein said step of comparing said four markers confirms the occurrence of an ischemic cerebral event or a hemorrhagic cerebral event and further distinguishes which type of cerebral event has occurred.