Patent ID: 7824681
Filing Date: 2010-11-02
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated monoclonal antibody or an antigen binding fragment thereof, comprising a variable region of a heavy chain and a variable region of a light chain, and wherein the variable region of the light chain comprises amino acids 37-47 of the amino acid sequence set forth in SEQ ID NO: 8, amino acids 60-68 of the amino acid sequence set forth in SEQ ID NO: 8 and amino acids 99-109 of the amino acid sequence set forth in SEQ ID NO: 8, and wherein the variable region of the heavy chain comprises amino acids 34-41 of the amino acid sequence set forth in SEQ ID NO: 11, amino acids 59-65 of the amino acid sequence set forth in SEQ ID NO: 11 and amino acids 105-109 of the amino acid sequence set forth in SEQ ID NO: 11, and wherein the monoclonal antibody or the antigen binding fragment thereof specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (K d ) of 1 nM or less and binds IGF-I with an equilibrium dissociation constant (K d ) of 1 mM or greater.