Patent ID: 6251928
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A method for treating a condition associated with .beta.-amyloid peptide in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of the formula ##STR5##wherein:n is 0, 1, 2, 3, or 4;q is 0, 1, 2, 3, or 4;A is --O--, --NH--, or --S(O).sub.m --; where m is 0, 1, or 2;R.sup.1 is hydrogen, C1-C.sub.6 alkyl, di(C.sub.1 -C.sub.6 alkyl)amino-, amino, (C.sub.1 -C.sub.6 alkyl)amino-, cyano(C.sub.1 -C.sub.6 alkyl)-, or carboxy(C.sub.1 -C.sub.6 alkylidene)-;R is phenyl, oxazolyl, benzophenonyl, or naphthyl optionally substituted with one or more substituents selected from the group consisting ofC.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkanoyl, hydroxy, nitro, rhodanine, C.sub.2 -C.sub.10 alkanoyloxy, hydrogen, phenyl, phenyl(C.sub.1 -C.sub.6 alkylidenyl)-, heterocycle, heterocycle(C.sub.1 -C.sub.6 alkylidenyl)-, unsaturated heterocycle, unsaturated heterocycle(C.sub.1 -C.sub.6 alkylidenyl)-, halo, C.sub.1 -C.sub.10 alkylamino, C.sub.1 -C.sub.10 alkoxy, benzoyl, and C.sub.1 -C.sub.10 alkylthio,said phenyl, phenyl(C.sub.1 -C.sub.6 alkylidenyl)-, benzoyl, heterocycle, heterocycle(C.sub.1 -C.sub.6 alkylidenyl)-, unsaturated heterocycle(C.sub.1 -C.sub.6 alkylidenyl)-, rhodanine, and unsaturated heterocycle moieties being optionally substituted with one or more halo, C.sub.1 -C.sub.6 alkyl, hydroxy, carboxy, or C.sub.1 -C.sub.6 alkoxy groups;with the proviso that if, q is 0, R.sup.1 is hydrogen, and n is 2, then unsubstituted phenyl;or a pharmaceutically acceptable salt thereof.