Patent ID: 8791086
Filing Date: 2014-07-29
Classification: A61K,A61P,C12N

Abstract:
1. A pharmaceutical composition comprising, a polyion complex comprising a polyanionic substance as an active ingredient that suppresses the expression of PHD2, a polycation chargeable polymer, and glycosaminoglycan, which forms a ternary system complex of the polyion complex and glycosaminoglycan, wherein the polyanionic substance is selected from the group consisting of RNAi inducing nucleic acid against PHD2 or an expression vector thereof, antisense nucleic acid against PHD2 or an expression vector thereof, and a ribozyme against PHD2 or an expression vector thereof, and the polycation chargeable polymer is a chargeable polymer represented by the following formula (III), a block copolymer represented by the following formula (I) or (II), or a salt thereof, wherein, R R R R R R the total of R R L m is an integer of 5-20,000, n is an integer of 2-5,000, y is an integer of 0-5,000, z is an integer of 0-5,000, and y+z is not larger than n, and each repeat unit in the above formulas may be present in the above specified order or may be present in a random order.