Patent ID: 8877785
Filing Date: 2014-11-04
Classification: A61P,C07D

Abstract:
1. A method of increasing the anticancer activity towards a chemotherapeutic drug used to treat a tumor, wherein the tumor is melanoma, said method comprising: administering a sufficient amount of the chemotherapeutic drug to a subject in need thereof, wherein the chemotherapeutic drug consists of temozolomide, identifying the mechanisms induced in the tumor microenvironment that may interfere with the anticancer activity, administering a sufficient amount of a drug consisting of carboxyamidotriazole orotate to induce anticancer activity and to target the mechanisms identified that interfere with the anticancer activity in the tumor microenvironment, measuring the pharmacodynamic interaction between temozolomide and carboxyamidotriazole orotate to determine the time of administration and an optimum combinatorial dose of each drug that achieves therapeutic levels, and administering the pre-determined optimum combinatorial dose to achieve maximum anticancer activity, least interference in the microenvironment or least toxicity to non-tumored cells.