Patent ID: 6433168
Filing Date: 2002-08-13
Classification: C07D

Abstract:
A method for producing 10-(3-halogeno-1-azabicyclo[2.2.2]oct-3-ylmethyl)phenothiazine of the formula [I]wherein X is a halogen atom, which comprises Step 1: adding an alkali metal compound to a mixture comprising dimethyl sulfoxide, 3-quinuclidinone or a salt thereof, and trimethyloxosulfonium halide to give 3-methylenequinuclidine oxide of the formula [II]Step 2: reacting the obtained 3-methylenequinuclidine oxide with an alkali metal salt of phenothiazine to give a hydroxyl compound of the formula [III]Step 3: reacting the hydroxyl compound or a hydrate thereof with a halogenation agent in a reaction solvent to give the phenothiazine compound of the formula [I].