Patent ID: 6124353
Filing Date: 2000-09-26
Classification: A61K,Y10S

Abstract:
A method of treating ocular hypertension which comprises applying to the eye an amount sufficient to treat ocular hypertension of a compound of formula (I) while lowering hyperemia as compared to the corresponding iso form of the compound ##STR7## wherein the wavy line attachments indicate either alpha (.alpha.) or beta (.beta.) configuration; hatched lines indicate .alpha. configuration, solid triangles are used to indicate .beta. configuration; the dashed bonds represent a single bond or a double bond which can be in the cis or trans configuration; X is selected from the group consisting of H, R or a pharmaceutically-acceptable cation, and R is an aliphatic hydrocarbon group of about 1 to about 6 carbon atoms; one of R.sub.1 and R.sub.2 is .dbd.O, --OH or an --O(CO)R.sub.4 group, and the other one is --OH or an --O(CO)R.sub.4 group or R.sub.1 is .dbd.O and R.sub.2 is H; R.sub.3 is --OH or --O(CO)R.sub.4, wherein R.sub.4 is a saturated or unsaturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or --(CH.sub.2).sub.n R.sub.5 wherein n is 0-10, and R.sub.5 is an aliphatic ring from about 3 to about 7 carbon atoms, or an aromatic ring; or a pharmaceutically acceptable salt thereof.