Patent ID: 7524668
Filing Date: 2009-04-28
Classification: C07K,C12N

Abstract:
1. An isolated crystal of beta secretase (BACE) co-crystallized with a ligand, wherein the amino acid sequence of said beta secretase consists of SEQ ID NO:3, said crystal has monoclinic space group symmetry C2, a unit cell having dimensions of a, b, and c, wherein a is 73 Å±20 Å, b is 105 Å±20 Å, c is 50 Å±10 Å, and α=γ=90°, and β is 95°±10°, wherein said ligand is N1-((2S,3R)-4-(3-iodobenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)-5-methyl-N3,N3-dipropylbenzene-1,3,-diamide.