Patent ID: 8748151
Filing Date: 2014-06-10
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A polypeptide comprising: (a) a heavy chain (HC) domain of a neurotoxic component of a clostridial toxin; (b) a first light chain (LC) domain of a neurotoxic component of a clostridial toxin; and (c) at least one further LC domain of a neurotoxic component of a clostridial toxin; wherein the domains are connected by a direct linkage via a covalent bond, a peptide-linker, a chemical linker, or a combination of two or more thereof, and wherein the first and at least one further LC domains may be the same or different from each other, and wherein each of the first and at least one further LC domains exhibit proteolytic activity.