Patent ID: 6482829
Filing Date: 2002-11-19
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula whereinR1 is hydrogen, lower alkyl, lower alkenyl, phenyl or the following groups â€”(CH2)m-non aromatic heterocyclic, which is unsubstituted or substituted by lower alkyl, or is â€”(CH2)m-heteroaryl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, CF3, benzyl or cyano, or is â€”(CH2)mâ€”C(O)â€”NRRâ€², â€”(CH2)mâ€”C(O)-lower alkyl, â€”(CH2)mâ€”C(O)â€”O-lower alkyl, â€”(CH2)mâ€”O-lower alkyl, â€”(CH2)mâ€”CH[C(O)â€”O-lower alkyl]2, â€”(CH2)mCH(OH)â€”CH2â€”O-phenyl, â€”(CH2)mâ€”CH(CF3)OH, â€”(CH2)mâ€”OH, â€”(CH2)mâ€”CN, â€”(CH2)mâ€”NRRâ€², â€”(CH2)m-cycloalkyl or â€”(CH2)mâ€”CHF2 R2 is hydrogen, lower alkyl, halogen or lower alkoxy; R3 is lower alkyl, lower alkoxy, halogen or CF3; R,Râ€² are the same or different and are hydrogen or lower alkyl; X is >Nâ€”, or >CHâ€”; X1/X2 are hydrogen, hydroxy or lower alkoxy or taken together to form an oxo group; Y1/Y2 are hydrogen, lower alkyl, â€”(CH2)m-phenyl or taken together to form an oxo group; Z â€”(CH2)qâ€” or â€”C(O)â€”; m is 0, 1, 2, 3 or 4; n is 2 or 3; nâ€² 0, 1 or 2; q is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof.