Patent ID: 6365127
Filing Date: 2002-04-02
Classification: C07K,C12N

Abstract:
A thyroid stimulating hormone beta chain produced by a cell transformed with a vector comprising a DNA sequence encoding the beta subunit of human thyroid stimulating hormone, wherein the DNA sequence comprises the following sequence:(a) a first sequence ATG ACT GCT CTC TTT CTG ATG TCC ATG CTT TTT GGC CTT GCA TGT GGG CAA GCG ATG TCT TTT TGT ATT CCA ACT GAG TAT ACA ATG CAC ATC GAA AGG AGA GAG TGT GCT TAT TGC CTA ACC ATC AAC ACC ACC ATC TGT GCT GGA TAT TGT ATG ACA CGG; (b) a second sequence of about 400-450 nucleotides following the first sequence; and (c) a third sequence GAT ATC AAT GGC AAA CTG TTT CTT CCC AAA TAT GCT CTG TCC CAG GAT GTT TGC ACA TAT AGA GAC TTC ATC TAC AGG ACT GTA GAA ATA CCA GGA TGC CCA CTC CAT GTT GCT CCC TAT TTT TCC TAT CCT GTT GCT TTA AGC TGT AAG TGT GGC AAG TGC AAT ACT GAC TAT AGT GAC TGC ATA CAT GAA GCC ATC AAG ACA AAC TAC TGT ACC AAA CCT CAG AAG TCT TAT CTG GTA GGA TTT TCT GTC TAA following the second sequence.