Patent ID: 6399643
Filing Date: 2002-06-04
Classification: A61P,C07D

Abstract:
A compound of the formula I, or a physiologically acceptable salt thereof, or a stereoisomeric form or mixture thereof, or a prodrug thereof, wherein the compound has the formula: and wherein:R1 is hydrogen or methyl; R2 is unsubstituted phenyl, substituted phenyl or (C1-C4)-alkyl; X is â€”CH2â€”CH2â€” or â€”CH2â€”CH2â€”CH2â€”, where one of the CH2 groups in these two residues is optionally replaced by a carbonyl group C&boxH;O; W is isopropyl or cyclopropyl; V is hydrogen or methoxy; E is â€”COâ€”R3, â€”COâ€”H, â€”CH2â€”Oâ€”R4, â€”CH2â€”Oâ€”COâ€”R4, â€”CH2â€”Oâ€”COâ€”Oâ€”R5 or 5-tetrazolyl; R3 is hydroxy, (C1-C10)-alkoxy, phenyl-(C1-C8)-alkoxy-, phenyloxy-, (C1-C8)-alkylcarbonyloxy-(C1-C6)-alkoxy-, phenylcarbonyloxy-(C1-C6)-alkoxy-, phenyl-(C1-C6)-alkylcarbonyloxy-(C1-C6)-alkoxy-, (C1-C8)-alkoxycarbonyloxy-(C1-C6)-alkoxy-, phenyloxycarbonyloxy-(C1-C6)-alkoxy-, phenyl-(C1-C6)-alkoxycarbonyloxy-(C1-C6)-alkoxy-, amino, mono-((C1-C10)-alkyl)-amino-, di-((C1-C10)-alkyl)-amino- or R4R4Nâ€”COâ€”(C1-C6)-alkoxy- in which the residues R4 are independent of one another and may be identical or different, wherein each phenyl residue of R3 is unsubstituted phenyl or substituted phenyl; R4 is hydrogen, (C1-C10)-alkyl, unsubstituted phenyl, substituted phenyl or phenyl-(C1-C8)-alkyl-, wherein the phenyl residue is unsubstituted phenyl or substituted phenyl; R5 has one of the meanings of R4 with the proviso that R4 is not hydrogen; wherein substituted phenyl residue is substituted by one or more identical or different substituents from the group consisting of (C1-C4)-alkyl, (C1-C4)-alkoxy, methylenedioxy, ethylenedioxy, halogen, trifluoromethyl and trifluoromethoxy.