Patent ID: 7205384
Filing Date: 2007-04-17
Classification: A61P,C07D

Abstract:
1. A process for the preparation of a compound of formula (IIa) reacting a compound of formula (IIIa), wherein Pg to yield the corresponding compound of formula (IVa), wherein Q  reacting the compound of formula (IVa) with a solution or suspension of a compound of formula (Va), wherein X is selected from the group consisting of Cl, Br and I; in an anhydrous organic solvent which is inert to the compound of formula (Va); to yield the corresponding compound of formula (VIa);  subjecting the compound of formula (VIa) to selective de-protection, to yield the corresponding compound of formula (VIIa) or its corresponding acid addition salt;  reacting the compound of formula (VIIa) with a compound of formula (VIIIa), wherein Pg to yield the corresponding compound of formula (IXa); de-protecting the compound of formula (IXa), to yield the corresponding compound of formula (IIa).