Patent ID: 7485754
Filing Date: 2009-02-03
Classification: C07D

Abstract:
1. A process for the preparation of compounds including the optically enriched (R)- and (S)-enantiomers of the compounds, and pharmaceutically acceptable addition salts thereof, comprising the steps of reacting compounds of formula 2, wherein Ar is an aryl group; the carbon center marked with “*” can be racemic or enantiomerically enriched having the (R) — or (S ) — configuration; R 1 and R 2 individually represent hydrogen, C1-C10 alkyl, aryl, and aralkyl groups; with an aryl halide of formula Ar 1 X (6), wherein Ar 1 is an awl group and X is a halogen, in the presence of a suitable copper containing catalysts and a base or mixture of bases to produce a 3-aryloxy-3-arylpropylamine of formula 1: wherein Ar, Ar 1 , R 1 , R 2 , and “*” are as defined above.