Patent ID: 6638563
Filing Date: 2003-10-28
Classification: A61L,B82Y,C08J,G02B

Abstract:
A method for treating the surface of a medical device comprising:(a) forming a medical device from a material comprising monomeric units having reactive functionalities selected from the group consisting of azlactone, carboxylic acid, amine, hydroxy and epoxy functionalities, and combinations thereof; (b) forming a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, said complementary reactive functionalities selected from the group consisting of azlactone, isocyanate, acid anhydride, epoxy, hydroxy, primary amine, secondary amine and carboxylic acid functionalities, and combinations thereof, wherein: when the hydrophilic reactive polymer comprises hydroxy or amine complementary reactive functionalities, the medical device monomeric units comprise azlactone reactive functionalities, or when the hydrophilic reactive polymer comprises carboxylic acid complementary functionality, the medical device monomeric units comprise epoxy reactive functionalities; (c) reacting the hydrophilic reactive polymer of (b) having complementary reactive functionalities along the polymer chain with said medical device monomeric unit reactive functionalities on or near the surface of the medical device of (a), at a reaction temperature at least sufficient to maintain the hydrophilic reactive polymer in solution and less than 55Â° C., thus forming a biocompatible surface on the medical device; (d) removing the biocompatible surface of step (c); and (e) repeating steps (b) and (c) to form a renewed biocompatible surface on said medical device having properties similar to the original biocompatible surface of step (c).