Patent ID: 7914998
Filing Date: 2011-03-29
Classification: A01K

Abstract:
1. A method for identifying an agent capable of extending the mature life phase of a nematode, comprising: contacting a nematode having altered activity or expression of a cholinergic pathway molecule selected from the group consisting of EGL-8, RIC-8 and RIC-4, and altered activity or expression of DAF-2 with a test agent, wherein said altered activity or expression of the cholinergic pathway molecule or said altered activity or expression said DAF-2 extends the mature life phase of the nematode; assaying for the ability of the test agent to increase the lifespan of the nematode as compared to a suitable control, and selecting an agent that increases the lifespan, to thereby identify an agent capable of extending the mature life phase of a nematode.