Patent ID: 6558662
Filing Date: 2003-05-06
Classification: A61K,A61P,Y10S

Abstract:
A method of treating a subject having a hematologic disorder comprising:administering a myeloreductive non-myeloablative treatment to the subject in an amount sufficient for inducing mixed hematopoietic chimerism in the subject, introducing into the subject allogeneic donor hematopoietic stem cells (donor cells) to form chimeric bone marrow in the subject after the myeloreductive non-myeloablative treatment has cleared the blood stream of the subject, treating the subject with an immunosuppressant regimen, after introduction of the donor cells, in an amount sufficient to prevent a graft-versus-host response mediated by the donor cells and to prevent rejection of the donor cells such that mixed hematopoietic chimerism is induced in the subject.