Patent ID: 6420363
Filing Date: 2002-07-16
Classification: A61P,C07C,C07D,G06F,Y02P

Abstract:
A mono- or polyenic carboxylic acid derivative represented by the formula (1-I) or a physiologically acceptable salt thereof:Zâ€”(CR3&boxH;CR2)nâ€”COOR1â€ƒâ€ƒ(1-I) whereinR1 is hydrogen or a carboxyl-protecting group; R2 and R3 are each independently hydrogen, halogen, linear lower alkyl, branched lower alkyl, linear lower alkoxy, branched lower alkoxy or aryl; n is an integer of 1 to 3 and the number of R's or R3's may be the same or different from each other; and Z represents a group of the formula wherein Ra, Rb and Rc are each independently hydrogen, linear or branched lower alkyl, linear or branched lower alkoxy, cycloalkyl, aryl, heteroaryl, fluoroalkyl or halogen or alternatively two of Ra, Rb and Rc may be united to form an optionally substituted, saturated or unsaturated ring which may contain oxygen, sulfur and/or nitrogen; Raâ€² and Rbâ€² are each independently hydrogen, linear or branched lower alkyl linear or branched lower alkoxy, cycloalkyl, aryl heteroaryl, fluoroalkyl or halogen, provided 3-(2-phenazinyl)-2-propenoic acid, 3-(2-phenazinyl)-2-propenoic acid methyl ester and 5,10-dihydro-5,10-dimethyl-2-phenazineacrylic acid are excluded.