Patent ID: 6051713
Filing Date: 2000-04-18
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula ##STR10## wherein R.sub.1 is independently H or alkyl of 1 to 6 carbons;m is an integer having the value of 0-5;p is an integer having the value of 0-2;r is an integer having the value 0-2;the pyridyl group bearing the A-B group is optionally substituted with one or two R.sub.1 groups;W is a substituent selected independently from the group consisting of F, Br, Cl, I, C.sub.1-6 alkyl, fluoro substituted C.sub.1-6 alkyl, NO.sub.2, N.sub.3, OH, OCH.sub.2 OCH.sub.3, OC.sub.1-10 alkyl, tetrazol, CN, SO.sub.2 C.sub.1-6 -alkyl, SO.sub.2 C.sub.1-6 -fluoro substituted alkyl, SO--C.sub.1-6 alkyl, CO--C.sub.1-6 alkyl, COOR.sub.8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl;A is (CH.sub.2).sub.q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds, andB is COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, CR.sub.7 OR.sub.13 O, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11, is lower alkyl, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons.