Patent ID: 6211364
Filing Date: 2001-04-03
Classification: A61P,C07C,C07D,C40B

Abstract:
A compound of the Formula III' ##STR23##R.sup.1 is selected from the group consisting of hydrogen, --OR.sup.4, --SR.sup.5, C.sub.1 -C.sub.3 alkyl, C.sub.2 -C.sub.3 alkenyl, halo, --CN, --COR.sup.4b', and --OC(O)--R.sup.15 ;m2 is from 0 to 2;R.sup.4 is hydrogen, C.sub.1 -C.sub.3 alkyl;R.sup.5 is hydrogen, C.sub.1 -C.sub.3 alkyl;R.sup.10 is selected from the group consisting of hydrogen, carbonyl, halo, and C.sub.1 -C.sub.3 alkyl;R.sup.11 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.3 alkyl;R.sup.12 is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, and aryl;R.sup.13 is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, and aryl; orR.sup.12 and R.sup.13 together with the nitrogen to which they are attached form a group of the formula II: ##STR24##II' wherein the II' group is a group of Formula II which is unsaturated; orR.sup.11 and R.sup.12 together with the nitrogen and carbon to which they are bound can join to form a three to six membered ring;R.sup.14 is selected from the group consisting of H, halo, C.sub.1 -C.sub.3 alkyl, S(O).sub.m3 and --OR.sup.16 ;R.sup.15 is C.sub.1 -C.sub.3 alkyl or aryl;R.sup.16 is C.sub.1 -C.sub.3 alkyl;R.sup.17 is independently selected from the group consisting of hydrogen, --OR.sup.4', --SR.sup.5', C.sub.1 -C.sub.3 alkyl, C.sub.2 -C.sub.3 alkenyl, halo, --CN, S(O).sub.m2', --COR.sup.4b, and --OC(O)--R.sup.15 ;R.sup.4b and R.sup.4b' are each independently selected from hydrogen and C.sub.1 -C.sub.3 alkyl;R.sup.15' is C.sub.1 -C.sub.3 alkyl or aryl;m2' is 0 to 2;R.sup.4' is hydrogen, C.sub.1 -C.sub.3 alkyl;R.sup.5' is hydrogen, C.sub.1 -C.sub.3 alkyl;m2 is 0 to 2;X is selected from the group consisting of C, O, S, N, carbonyl, and a bond;n' is 0 to 2;m' is 0 to 2;m3 is 0 to 2;n is 0 to 3;R.sup.20 is selected from the group consisting of benzyl, 3,4-dimethoxybenzyl, o-nitrobenzyl, and triphenylmethyl; carbamates of the formula --COOR wheren R is selected from the group consisting of methyl, ethyl, propyl, isopropyl, 2,2,2-trichloroethyl, 1-methyl-1-phenylethyl, isobutyl, t-butyl, t-amyl, vinyl, allyl, phenyl, benzyl, p-nitrobenzyl, o-nitrobenzyl, and 2,4-dichlorobenzyl; and formyl; ora pharmaceutically acceptable salt or solvate thereof.