Patent ID: 6797815
Filing Date: 2004-09-28
Classification: A61K,C12N,C12Y

Abstract:
A compound having the formula I: wherein, R1 is OH, Oâ€”R3, wherein R3 is independently a moiety selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, Câ€”R3, wherein R3 is independently a moiety selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, halo, NHR4, wherein R4 is independently a moiety selected from the group consisting of alkyl (C1-22), acyl (C1-22), substituted or unsubstituted aryl, or OCH2SCH3 (methylthiomethyl), ONHR5, wherein R5 is independently a moiety selected from the group consisting of H, aminoacyl group, peptidyl group, biotinyl group, cholesteryl group, lipoic acid residue, retinoic acid residue, folic acid residue, ascorbic acid residue, nicotinic acid residue, 6-aminopenicillanic acid residue, 7-aminocephalosporanic acid residue, alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide or ester, ON=R6, wherein R6 is independently a moiety selected from the group consisting of pyridoxal residue, pyridoxal-5-phosphate residue, 13-cis-retinal residue, 9-cis-retinal residue, alkyl, alkenyl, alkynyl, alkylaryl, carbocyclic alkylaryl, or heterocyclic alkylaryl; B is independently a nucleotide base or hydrogen; X is independently a phosphorus-containing group; and R2 is independently a blocking group or a phosphorus-containing group.