Patent ID: 9072789
Filing Date: 2015-07-07
Classification: A61K

Abstract:
1. Particles comprising oxide, oxysulfide, or phosphate host particles with a self-assembled monolayer consisting of organophosphonate ligands covalently bonded thereto, wherein said host particles comprise ions of one or more rare earth elements, wherein said covalent bonding to the host particle surfaces is via tridentate phosphonate coordination, wherein said particles are less than about 100 microns in size, and wherein said organophosphonate ligands are of formula: wherein R is selected from the group consisting of linear alkyl, branched alkyl, linear alkylenyl, and branched alkylenyl moieties having from about two to about 40 carbon atoms, 0 to about 20 heteroatoms selected independently from oxygen and nitrogen, and omega-functionalized organic moieties, and wherein a photosensitizer compound or one or more biomolecular probes are covalently attached via said omega-functionalized organic moieties.