Patent ID: 7541466
Filing Date: 2009-06-02
Classification: A61K

Abstract:
1. A compound represented by structural formula Ib: wherein: X1 and X2 are independently —C(O)— or —S(O)—; X3, X4, X5, and X6 are —CH—; Ring B is optionally substituted at any substitutable carbon; m is 0, 1 or 2; each R4 is independently halogen, —OH, —SH, —R i) R1 is —H; R2 is —X7-R6, wherein or, R1 and R2, taken together with the nitrogen to which they are bonded, are an optionally substituted 6-membered heterocyclic group; and R3 is a six-membered aryl or heteroaryl group that is substituted or is fused to another ring; or ii) R1 and R2 are independently —H or an optionally substituted aliphatic, aryl, heteroaryl, heterocyclic, or monocyclic cycloalkyl group, provided that R1 and R2 are not both —H; or, R1 and R2, taken together with the nitrogen to which they are bonded, are an optionally substituted heterocyclic group; and R3 is an optionally substituted 2-naphthyl, 6-(1,4 benzodioxan)yl, 6-indolyl, or 2-(9-fluorenon)yl group, or a phenyl or pyridyl group substituted with one or more groups selected from halogen, —CF wherein optional substituents on the aliphatic group are, independently, —OH, halogen (—Br, —Cl, —I and —F), —R, —OR, —CH wherein X is—O—, —S—, —C(O)—, —S(O)—, —CH each R each R R