Patent ID: 8377439
Filing Date: 2013-02-19
Classification: A61K,A61P,C07K,C12N,F01D,F16B,Y02T

Abstract:
1. An isolated antagonist antibody or antigen-binding fragment thereof that comprises the three CDRs of the variable light chain set forth at positions 24 through 34, positions 50 through 56, and positions 89 through 97 of SEQ ID NO 3 and the three CDRs of the variable heavy chain set forth at positions 26 through 35, positions 50 through 64, and positions 99 through 107 of SEQ ID NO: 4, wherein the antibody binds the extracellular domain of EphB3 with an affinity (K D ) of 10 −6 M or less.