Patent ID: 6492394
Filing Date: 2002-12-10
Classification: A61P,C07C,C07D

Abstract:
A compound selected from the compounds of Formula (I): wherein:Z is â€”NHOH; R1 is 1) alkyl substituted with â€”NRaRb, â€”ORc, or â€”S(O)nâ€”Rd, where n is 0 to 2, Ra is hydrogen, alkyl, or â€”COR (where R is hydrogen, alkyl, or haloalkyl); Rb is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, heterocyclylhydroxyalkyl, â€”COR (where R is hydrogen, alkyl, haloalkyl, monosubstituted aminoalkyl, aryloxyalkyl, cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, or -(alkylene)-C(O)â€”X (where X is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, or heterocyclylalkyl), â€”SO2R (where R alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino or disubstituted amino), â€”COOR (where R is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, or heterocyclylalkyl), â€”CONRâ€²Râ€³, or -(alkylene)-CONRâ€²Râ€³ (where Râ€² and Râ€³ are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, heteroaralkyl, or â€”SO2R (where R is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino or disubstituted amino), or Râ€² and Râ€³ together with the nitrogen atom to which they are attached form a heterocyclyl ring); Rc is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heterocyclylalkyl, â€”COR (where R is alkyl, haloalkyl or heterocyclyl), or â€”CONRâ€²Râ€³ (where Râ€² and Râ€³ are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl); and Rd is hydrogen (provided that n is 0), alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, amino, monosubstituted amino, or disubstituted amino; or 2) -(alkylene)-C(O)â€”X where X is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, hydroxy, alkoxy, cycloalkoxy, cycloalkylalkoxy, heteroalkyloxy, aralkyloxy, or heteroaralkyloxy; R is â€”CH(R2)Ar1 or â€”CH(R2)CH&boxH;CHAr1 where R2 is hydrogen or alkyl; and Ar1 is heteroaryl; Ar2 is either: (i) a phenyl ring of formula (a): â€ƒwherein: R3 and R7 are, independently of each other, hydrogen, alkyl, alkylthio, or halo; R4 and R6 are, independently of each other, hydrogen, alkyl, or halo; R5 is alkyl, haloalkyl, heterocyclyl, alkylthio, arylthio, aralkylthio, heteroarylthio, heteroaralkylthio, cycloalkylthio, cycloalkylalkylthio, alkoxy, aryloxy, aralkoxy, heteroaryloxy, heteroaralkyloxy, cycloalkoxy, cycloalkylalkoxy, alkyloxycarbonyl, hydroxy, halo, cyano, carboxy, nitro, amino, monoalkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, heteroarylsulfonyl, heteroaralkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, or â€”Y-(alkylene)-C(O)â€”Z where Y is a bond, â€”NRaâ€”, â€”Oâ€”, or â€”S(O)nâ€” (where n is 0 to 2), Ra is hydrogen or alkyl, and Z is alkoxy, hydroxy, amino, monosubstituted amino, or disubstituted amino; or R5 together with R4 forms â€”Oâ€” (CR8R9)nâ€” where n is 2 or 3 and each R8 and R9 are, independently of each other, hydrogen or alkyl; or the carbon atoms to which R5 and R4 are attached are fused to the C2-C3 carbons of a benzofuran ring; provided that at least two of R3, R4, R6, and R7 are not hydrogen at the same time; or (ii) a naphthyl ring of formula (b): â€ƒwherein: R10 is hydrogen, alkyl, alkoxy, or halo; and R11 is hydrogen, alkyl, haloalkyl, alkylthio, alkoxy, alkyloxycarbonyl, aryloxy, hydroxy, halo, cyano, carboxy, nitro, amino, monoalkylamino, dialkylamino or alkylsulfonyl; provided that both R10 and R11 are not hydrogen at the same time; and their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers.