Patent ID: 7741473
Filing Date: 2010-06-22
Classification: A61P,C07F,C07H

Abstract:
1. A process for preparing a compound of Formula I, or a pharmaceutically acceptable salt, solvate, hydrate, or tautomer thereof, comprising the steps of: (a) obtaining compounds of Formula II, which is a mixture of cis and trans-diastereomers, wherein cis and trans refer to the positions of R (b) reacting the mixture with a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained; wherein D R R A is wherein; n and p are 0, 1,or 2 such that the sum of n+p is from 0 to 3; each M is independently hydrogen, NH T X G is M, wherein: L is R L is (CO); Q is O, S, or absent; and T is R B is a purine or an azapurine residue linked though the 9-position, as in Formula III: or a pyrimidine residue linked though the 1-position, as in Formula IV: wherein: R R R when R J is carbon or nitrogen, with the proviso that when J is nitrogen, R R R R R R R R wherein the substituents of the substituted groups are independently selected from the group consisting of hydroxy, oxo, nitro, methoxy, ethoxy, alkoxy, fluoro, chloro, bromo, iodo, methyl, ethyl, propyl, butyl, alkyl, thio, thioalkyl, acyl, carboxyl, alkoxycarbonyl, carboxamido, alkylsulfonyl, alkylsulfinyl, alkylsulfonylamino, sulfonamido, cyano, amino, substituted amino, acylamino, trifluoromethyl, trifluoromethoxy, phenyl, aryl, pyridyl, imidazolyl, heteroaryl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloalkyl, pyrrolidinyl, piperidinyl, morpholino, and heterocyclyl.