Patent ID: 9180205
Filing Date: 2015-11-10
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A composition for subcutaneous administration comprising an antibody in high concentration formulation buffer, wherein the antibody or immunoglobulin is concentrated to at least 300 mg/ml, wherein the buffer is pH 5.2 and comprises 6.2 mM citric acid monohydrate, 105 mM sodium chloride, 1.2 mM sodium citrate dihydrate, 8.7 mM sodium phosphate dibasic, 5.5 mM sodium phosphate monobasic, 0.1% polysorbate 80 and 66 mM mannitol, wherein the antibody is a chimeric, humanized or human antibody of nG1m1 allotype, wherein the nG1m1 allotype is characterized by glutamate at Kabat residue 356 and methionine at Kabat residue 358 of the antibody heavy chain.