Patent ID: 9056151
Filing Date: 2015-06-16
Classification: A61L

Abstract:
1. A medical implant comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents, wherein the enzyme treatment comprises digesting the collagen with ficin and deactivating the ficin with a non-alkaline sodium chlorite solution to maintain growth factors and morphogenic proteins otherwise stripped away by exposure to an alkaline solution, wherein the collagen is lyophilized by exposing the collagen to a vapor phase cross-linking agent, the cross-linking agent comprising at least one of acetaldehyde, dialdehyde starch, glycerol polyglycidyl ethers, polyethylene glycol diglycidyl ethers, polyvalent metallic oxides, or a combination thereof, wherein the collagen comprises cartilage fragments, a plasticizer and angiogenesis promoting factors, the angiogenesis promoting factors comprising SEMA3.