Patent ID: 6897196
Filing Date: 2005-05-24
Classification: A61K

Abstract:
1. A composition having an amphipathic characteristic comprising a hydrophilic portion and a hydrophobic portion joined by an ortho ester linker, wherein the ortho ester linker hydrolyzes at an increasing rate as the pH is reduced below 7, wherein cleavage of the ortho ester linker directly detaches the hydrophobic portion and eliminates the amphipathic characteristic, wherein the hydrophilic portion is selected from the group consisting of methoxypolyethylene, polyethyleneglycol, hydroxylated dendrons, poly(methyloxazoline), poly(ethyloxazoline) and polyvinylpyrrolidone and wherein the hydrophobic group is selected from the group consisting of diacyl glycerols, distearoylglycerol, dipalmitoylglycerol, dimyristoyl glycerol, dioleoyl glycerol, tocopherol, cholesterol, coenzyme Q, and ceramide.