Patent ID: 6211333
Filing Date: 2001-04-03
Classification: C07K,Y02P

Abstract:
A method of producing a peptide (I) consisting of the amino acid sequence of SEQ ID No: 6 or its salts, which method comprises reacting a peptide (II) consisting of the amino acid sequence of SEQ ID No: 4 or its salts, with a peptide (III) consisting of the amino acid sequence of SEQ ID No: 15 or its salts to produce a peptide (I') consisting of the amino acid sequence of SEQ ID No: 5 or its salts, followed by subjecting the peptide (I') to a de-protecting group reaction using an acid to obtain the peptide (I), said acid being C.sub.1-6 alkanesulfonic acid and being used at a ratio of about 5 to about 25 times (weight) of the peptide (I'), and followed by neutralizing the acid with a base at a temperature of about 15.degree. C. to about -15.degree. C.