Patent ID: 8692026
Filing Date: 2014-04-08
Classification: C07C

Abstract:
1. A process comprising: (i) combining at least 1,4-dibromo-2-fluorobenzene, isopropyl magnesium chloride, THF and a first solvent to form a first combination; (ii) combining at least the first combination, a formyl source, and a second solvent to form a second combination; (iii) crystallizing a first solid intermediate from the second combination using a crystallization agent; (iv) combining at least the solid intermediate, a third solvent comprising methanol, and a carbonate to form a third combination; (v) distilling substantially all of the third solvent from the third combination; (vi) combining the distilled third combination and isopropyl alcohol or one or more alkanes comprising heptane or to form a fourth combination; and (vii) yielding 4-bromo-2-methoxybenzaldehyde from the fourth combination.