Patent ID: 8214155
Filing Date: 2012-07-03
Classification: G16B

Abstract:
1. A method of analyzing a plurality of first nucleic acids that can interact with at least one target portion of respective target nucleic acids to identify at least one cluster of the first nucleic acids that potentially cooperate with one another so as to affect one or more biological functions, the method comprising: for each of the first nucleic acids, determining whether that first nucleic acid respectively interacts with each of the target nucleic acids, wherein the first nucleic acids and the target nucleic acids are from different nucleic acid families; for each interaction, identifying one or more biological data that are linked to the target nucleic acid of that interaction; for each of the first nucleic acids, associating, with that first nucleic acid, at least a portion of the biological data linked to the target nucleic acids with which that first nucleic acid interacts; creating, with a programmed computer system, a correlation matrix that indicates whether each of the identified biological data is associated with each of the first nucleic acids, wherein the identified biological data is a plurality of biological data, and wherein the correlation matrix provides a multi-dimensional position for each first nucleic acid, each dimension corresponding to a different one of the plurality of biological data; creating, with the programmed computer system, a distance matrix by calculating a distance between a multi-dimensional position of one first nucleic acid and a multi-dimensional position of another first nucleic acid for each pair of the first nucleic acids, wherein calculating a distance for a pair of the first nucleic acids includes: clustering, with the programmed computer system, the first nucleic acids based on the distances between the pairs of first nucleic acids in the distance matrix; linking a set of biological functions with the biological data associated with the first nucleic acids of a cluster; and assigning to the first nucleic acids of the cluster at least a portion of the linked biological functions.