Patent ID: 7887572
Filing Date: 2011-02-15
Classification: A61L

Abstract:
1. An implantable device comprising a bioactive patterning on the implantable device, the bioactive patterning comprising a plurality of pores on the device or a plurality of pores in a coating on the device, the plurality of pores being loaded with (a) a protein selected from the group consisting of fibronectin, laminin 5, elastin, silk elastin, collagen, and combinations thereof; and (b) an agent selected from the group consisting of an adhesion molecule comprising an RGD motif, a chemo-attractant of an endothelial cell, a NO releasing or NO generating agent, an agent that promotes endothelialization, and combinations thereof; wherein the protein(s) of (a) and the agent(s) of (b) are chemically bonded to one another via a spacer.