Patent ID: 6110884
Filing Date: 2000-08-29
Classification: C12N

Abstract:
A protease variant comprising a Tyr residue at one of positions 91, 167, 171, 192, 209, 214, or 263 (BPN' numbering), wherein Tyr 91 is substituted with Leu, Ile, Val, Gln, Asn, Ser, Thr, Glu, or His; Tyr 167 is substituted with Leu, Ile, Gln, Asn, Ser, Thr, or His; Tyr 171 is substituted with Phe, Leu, Ile, Gln, Asn, Ser, or His; Tyr 192 is substituted with Leu, Ile, Gln, Asn, Ser, Thr, or His; Tyr 209 is substituted with Ile, Val, Gln, Asn, Ser, Thr, Glu, or His; Tyr 214 is substituted with Phe, Leu, Ile, Val, Gln, Asn, Glu, or His; or Tyr 263 is substituted at Leu, Ile, Val, Gln, Asn, Ser, Thr, Glu, or His.