Patent ID: 8889426
Filing Date: 2014-11-18
Classification: A61K,A61P,G01N

Abstract:
1. A method of screening for compounds suitable for treatment of a hypophosphatemic condition, said method comprising: providing a receptor binding fragment of FGF23 consisting of the amino acid sequence of SEQ ID NO:12 or amino acid residues 1 to 21 of SEQ ID NO:11; providing binary FGFR-Klotho complex; providing one or more candidate compounds; combining the receptor binding fragment of FGF23, the binary FGFR-Klotho complex, and the candidate compounds under conditions effective for the receptor binding fragment of FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves; and identifying the candidate compounds which prevent formation of the ternary complex and bind the binary FGFR-Klotho complex as being suitable in treating hypophosphatemia associated with elevated or normal FGF23.