Patent ID: 6090821
Filing Date: 2000-07-18
Classification: A61P,C07D

Abstract:
A compound of Formula (II): ##STR53## wherein: A is O;R.sup.1 is --CF.sub.3 or --CF.sub.2 CF.sub.3 ;R.sup.2 is selected fromC.sub.1-3 alkyl substituted with 0-1 R.sup.4,C.sub.2-3 alkenyl substituted with 0-1 R.sup.4, andC.sub.2-3 alkynyl substituted with 0-1 R.sup.4,R.sup.3 is selected from H, methyl, ethyl, --OH, methoxy, ethoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, and --NHC(O)NR.sup.14 R.sup.15 ;R.sup.3a is selected from H, methyl, ethyl, --OH, methoxy, ethoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, and --NHC(O)NR.sup.14 R.sup.15 ;R.sup.3b is H or F;R.sup.3c is selected from H, methyl, --OH, methoxy, and --OCF.sub.3 ;R.sup.4 is selected fromcyclopropyl substituted with 0-1 R.sup.5,phenyl substituted with 0-3 R.sup.5, and a5-6 membered heterocyclic system containing 1-3 heteroatoms selected from O, N, and S, substituted with 0-1 R.sup.5, wherein the heterocyclic system is selected from 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-oxazolyl, 2-thiazolyl, 4-isoxazolyl, 2-imidazolyl, 1-pyrazolyl, 3-pyrazolyl, and 4-pyrazolyl;R.sup.5, at each occurrence, is independently selected frommethyl, ethyl, propyl, --OH, methoxy, ethoxy, propoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;Q.sup.1 is selected from:H, --CHO, --CO.sub.2 R.sup.7, --CH.sub.2 OR.sup.7, --COR.sup.7, --NO.sub.2, --NH.sub.2, --NHR.sup.7, --N(R.sup.7).sub.2, --NHCO.sub.2 R.sup.7, --NHCOR.sup.7, --OR.sup.7, --OCOR.sup.7, --CF.sub.3, --CF.sub.2 CF.sub.3, --CF.sub.2 CF.sub.2 CF.sub.3,C.sub.1-4 alkyl substituted with 0-1 R.sup.8,C.sub.2-3 alkenyl substituted with 0-1 R.sup.8, andC.sub.2-3 alkynyl substituted with 0-1 R.sup.8 ;Q.sup.2 is H;alternatively, Q.sup.1 and Q.sup.2 can be taken together to form .dbd.O;R.sup.7 is selected fromH, --CF.sub.3, --CF.sub.2 CF.sub.3, --CF.sub.2 CF.sub.2 CF.sub.3,C.sub.1-3 alkyl substituted with 0-1 R.sup.8,C.sub.2-3 alkenyl substituted with 0-1 R.sup.9,C.sub.2-3 alkynyl substituted with 0-1 R.sup.9,C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.9, andphenyl substituted with 0-2 R.sup.9 ;R.sup.8 is selected frommethyl, ethyl, propyl, butyl, --OH, methoxy, ethoxy, propoxy, butoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15,C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.9,phenyl substituted with 0-5 R.sup.9, and5-6 membered heterocyclic system containing 1-3 heteroatoms selected from O, N, and S, substituted with 0-2 R.sup.9 ; wherein the heterocyclic system is selected from 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-oxazolyl, 2-thiazolyl, 4-isoxazolyl, 2-imidazolyl, 1-pyrazolyl, 3-pyrazolyl, and 4-pyrazolyl;R.sup.9 is selected from methyl, ethyl, propyl, butyl, --CF.sub.3, --CF.sub.2 CF.sub.3, --CF.sub.2 CF.sub.2 CF.sub.3, --OH, methoxy, ethoxy, propoxy, butoxy, --OCF.sub.3, F, Cl, Br, I, --NR.sup.14 R.sup.15, --NO.sub.2, --CN, --C(O)R.sup.16, --NHC(O)R.sup.17, --NHC(O)NR.sup.14 R.sup.15, --NHSO.sub.2 R.sup.18, and --SO.sub.2 NR.sup.14 R.sup.15 ;R.sup.14 and R.sup.15 are independently selected from H, methyl, and ethyl;R.sup.16 is selected from H, OH, methyl, ethyl, methoxy, ethoxy, and NR.sup.14 R.sup.15 ;R.sup.17 is selected from methyl, ethyl, methoxy, and ethoxy; andR.sup.18 is selected from methyl, ethyl, and phenyl.