Patent ID: 6300331
Filing Date: 2001-10-09
Classification: A61P,C07D

Abstract:
A naphthalimidobenzamide compound represented by the following formula (1): ##STR150##wherein,R.sup.1 represents a hydrogen atom, a nitro group, a hydroxyl group, an amino group, a halogen atom, a cyano group, a carboxyl group, --CONH.sub.2, --NHCONH.sub.2, a C.sub.1-6 alkyl group, a trihalogenoalkyl group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkylamino group, a di(C.sub.1-6 alkyl)amino group, a C.sub.1-6 acyl group, a C.sub.1-6 alkylcarbamoyl group, a di(C.sub.1-6 alkyl)carbamoyl group, a C.sub.1-6 acylamino group, a C.sub.1-6 alkylureyl group or a C.sub.1-6 alkoxycarbonylamino group;R.sup.2 represents a hydrogen atom or an alkyl group;l stands for an integer of 1 to 3;A.sup.1 represents a linear or branched alkylene group which may be interrupted by --N(R.sup.3)-- (R.sup.3 representing a hydrogen atom or an alkyl group), --O--, --S--, --C(.dbd.O)NH--, --NHC(.dbd.O)--, --S(.dbd.O)-- or --S(.dbd.O).sub.2 --,X.sup.1 represents an aryl or heteroaryl group, an aryldicarbonylimino or heteroaryldicarbonylimino group, an arylamino or heteroarylamino group, an arylcarbonylamino or heteroarylcarbonylamino group, an arylcarbamoyl or heteroarylcarbamoyl group, an aryloxy or heteroaryloxy group, an arylthio or heteroarylthio group, an arylsulfinyl or heteroarylsulfinyl group, or an arylsulfonyl or heteroarylsulfonyl group; andY represents a hydrogen atom or --C(.dbd.O)N(R.sup.4)--A.sup.2 --X.sup.2 (R.sup.4 representing a hydrogen atom or an alkyl group and A.sup.2 representing a linear or branched alkylene group which may be interrupted by --N(R.sup.5)-- (R.sup.5 representing a hydrogen atom or an alkyl group), --O--, --S--, --C(.dbd.O)NH--, --NHC(.dbd.O)--, --S(.dbd.O)-- or --S(.dbd.O).sub.2 --, X.sup.2 representing a hydrogen atom, an aryl group, a heterocyclic group, an aryldicarbonylimino or heteroaryldicarbonylimino group, an arylamino or heteroarylamino group, an arylcarbonylamino or heteroarylcarbonylamino group, an arylcarbamoyl or heteroarylcarbamoyl group, an aryloxy or heteroaryloxy group, an arylthio or heteroarylthio group, an arylsulfinyl or heteroarylsulfinyl group, or an arylsulfonyl or heteroarylsulfonyl group, or R.sup.4, A.sup.2 and X.sup.2 may form, together with a nitrogen atom adjacent thereto, a nitrogen-containing heterocyclic ring;or a pharmaceutically acceptable salt thereof; andwhen an aryl ring exists in the group represented by X.sup.1, the aryl ring is a monocyclic to tetracyclic aryl group having 6 to 18 carbon atoms, and when a heteroaryl ring exists in the group represented by X.sup.1, the heteroaryl ring is a monocyclic to tetracyclic heteroaryl group having 1 or 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms and 2 to 17 carbon atoms, in which said aryl ring and said heteroaryl ring optionally have a substituent (I) selected from the group consisting of halogen atoms, a nitro group, a hydroxyl group, an amino group, C.sub.1-6 alkyl groups, C.sub.1-6 alkylamino groups, di(C.sub.1-6 alkyl)amino groups, C.sub.1-6 acylamino groups, C.sub.1-6 alkylcarbamoyl groups, di(C.sub.1-6 alkyl)carbamoyl groups, C.sub.1-6 alkylamino-C.sub.1-6 alkylcarbamoyl groups, di(C.sub.1-6 alkyl)amino-C.sub.1-6 alkylcarbamoyl groups and monocyclic nitrogen-containing heteroaryl groups; or a substituent (II) selected from the group consisting of monocyclic nitrogen-containing heteroarylcarbamoyl groups, monocyclic nitrogen-containing heteroarylcarbonylamino groups, monocyclic nitrogen-containing heteroarylcarbamoyl-monocyclic nitrogen-containing heteroarylcarbamoyl groups and monocyclic nitrogen-containing heteroarylcarbonylamino-monocyclic nitrogen-containing heteroarylcarbonylamino groups, each of which is further substituted by any one of the above-exemplified substituents (I); andwhen an aryl ring exists in the group represented by X.sup.2, the aryl ring is a monocyclic to tetracyclic aryl group having 6 to 18 carbon atoms, and when a heterocyclic group exists in the group represented by X.sup.2, the heterocyclic group is a monocyclic to tetracyclic, saturated or unsaturated heterocyclic group having a hetero atom selected from nitrogen, oxygen and sulfur atoms and 2 to 17 carbon atoms, in which said aryl ring and heterocyclic group optionally have a substituent (III) selected from halogen atoms, a nitro group, a hydroxyl group, an amino group, C.sub.1-6 alkyl groups, C.sub.1-6 alkylamino groups, di(C.sub.1-6 alkyl)amino groups, C.sub.1-6 acylamino groups, C.sub.1-6 alkylcarbamoyl groups, di(C.sub.1-6 alkyl)carbamoyl groups, C.sub.1-6 alkylamino-C.sub.1-6 alkylcarbamoyl groups, di(C.sub.1-6 alkyl)amino-C.sub.1-6 alkylcarbamoyl groups and monocyclic nitrogen-containing heterocyclic groups; or a substituent (IV) selected from monocyclic nitrogen-containing heterocyclic carbamoyl groups, monocyclic nitrogen-containing heterocyclic carbonylamino groups, monocyclic nitrogen-containing heterocyclic carbamoyl-monocyclic nitrogen-containing heterocyclic carbamoyl groups, monocyclic nitrogen-containing heterocyclic carbonylamino-monocyclic nitrogen-containing heterocyclic carbonylamino groups, each of which is further substituted by any one of the above-exemplified substituents (III).