Patent ID: 9221753
Filing Date: 2015-12-29
Classification: A61P,C07C,C07F

Abstract:
1. A process for preparing a vitamin D compound of formula (I) and an intermediate thereof: wherein R (a) mixing a ketone of formula (II): wherein R wherein R 8 represents a cyclohexanyl optionally substituted and optionally containing one or more double bonds, in a solvent having no influence on the reaction between the ketone and the allylphosphine oxide derivative; (b) evaporating the mixture to dryness to remove water, and dissolving the residue in another solvent; (c) cooling the resulting solution to a temperature of about −20° C. to room temperature; and (d) adding a base dropwise to the solution at a temperature of about −20° C. to room temperature; wherein the cyclohexanyl represented by R wherein the substituents on R