Patent ID: 8399461
Filing Date: 2013-03-19
Classification: A61P,C07D

Abstract:
1. A bicyclic heterocycle of formula (I) wherein R denotes a group selected from among cis-4-amino-cyclohexyl, trans-4-amino-cyclohexyl, cis-4-methylamino-cyclohexyl, trans-4-methylamino-cyclohexyl, cis-4-(methoxycarbonylamino)-cyclohexyl, trans-4-(methoxycarbonylamino)-cyclohexyl, cis-4-(N-methoxycarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-methoxycarbonyl-N-methyl-amino)-cyclohexyl, cis-4-(ethyloxycarbonylamino)-cyclohexyl, trans-4-(ethyloxycarbonylamino)-cyclohexyl, cis-4-(N-ethyloxycarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-ethyloxycarbonyl-N-methyl-amino)-cyclohexyl, cis-4-(tert.-butoxycarbonylamino)-cyclohexyl, trans-4-(tert.-butoxycarbonylamino)-cyclohexyl, cis-4-(N-tert.-butoxycarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-tert.-butoxycarbonyl-N-methyl-amino)-cyclohexyl, cis-4-(acetylamino)-cyclohexyl, trans-4-(acetylamino)-cyclohexyl, cis-4-(N-acetyl-N-methyl-amino)-cyclohexyl, trans-4-(N-acetyl-N-methyl-amino)-cyclohexyl, cis-4-(methoxyacetyl-amino)-cyclohexyl, trans-4-(methoxyacetyl-amino)-cyclohexyl, cis-4-(N-methoxyacetyl-N-methyl-amino)-cyclohexyl, trans-4-(N-methoxyacetyl-N-methyl-amino)-cyclohexyl, cis-4-(dimethylaminocarbonyl-amino)-cyclohexyl, trans-4-(dimethylaminocarbonyl-amino)-cyclohexyl, cis-4-(N-dimethylaminocarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-dimethylaminocarbonyl-N-methyl-amino)-cyclohexyl, cis-4-(morpholinocarbonyl-amino)-cyclohexyl, trans-4-(morpholinocarbonyl-amino)-cyclohexyl, cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl, cis-4-(piperazin-1-ylcarbonyl-amino)-cyclohexyl, trans-4-(piperazin-1-ylcarbonyl-amino)-cyclohexyl, cis-4-(N-piperazin-1-ylcarbonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-piperazin-1-ylcarbonyl-N-methyl-amino)-cyclohexyl, cis-4-[(4-methyl-piperazin-1-ylcarbonyl)-amino]-cyclohexyl, trans-4-[(4-methyl-piperazin-1-ylcarbonyl)-amino]-cyclohexyl, cis-4-[N-(4-methyl-piperazin-1-ylcarbonyl)-N-methyl-amino]-cyclohexyl, trans-4-[N-(4-methyl-piperazin-1-ylcarbonyl)-N-methyl-amino]-cyclohexyl, cis-4-(methanesulphonylamino)-cyclohexyl, trans-4-(methanesulphonylamino)-cyclohexyl, cis-4-(N-methanesulphonyl-N-methyl-amino)-cyclohexyl, trans-4-(N-methanesulphonyl-N-methyl-amino)-cyclohexyl, cis-4-phthalimido-cyclohexyl and trans-4-phthalimido-cyclohexyl,