Patent ID: 7074899
Filing Date: 2006-07-11
Classification: C07K

Abstract:
1. An isolated polypeptide selected from the group consisting of: (a) a polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO:1; (b) a polypeptide comprising a polypeptide sequence having at least 99% identity to the polypeptide sequence of SEQ ID NO:2, , wherein said polypeptide is encoded by a polynucleotide which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42° C. in a solution comprising: 50% formamide, 5×SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5×Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1×SSC at 65° C., (c) a polypeptide having at least 99% identity to the polypeptide sequence of SEQ ID NO:2, wherein said polypeptide is encoded by a polynucleotide which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42° C. in a solution comprising: 50% formamide, 5×SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5×Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1×SSC at 65° C., wherein said polypeptide possesses ephrinA ligand binding activity.