Patent ID: 9181198
Filing Date: 2015-11-10
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein: (A) is phenyl, wherein said phenyl has n substituents (R3); (B) is a cyclyl group or an -(L1)-cyclyl group, wherein said cyclyl group or the cyclyl moiety comprised in said (L1)-cyclyl group has n substituents (R2), and wherein said cyclyl group or the cyclyl moiety comprised in said -(L1)-cyclyl group is a phenyl group; (L1) is —O—, —NH—, —N(alkyl)-, alkylene or heteroalkylene; (D) is a heteroaryl group or an -(L2)-heteroaryl group, wherein said heteroaryl group or the heteroaryl moiety comprised in said -(L2)-heteroaryl group is imidazolyl, pyrazolyl, triazolyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxadiazolyl, oxazolyl, isothiazolyl, pyrrolyl, thiadiazolyl or furazanyl, wherein said heteroaryl group or the heteroaryl moiety comprised in said -(L2)-heteroaryl group has one substituent (R1), and further wherein said heteroaryl group is covalently bonded to the remainder of the molecule through a ring carbon atom or the heteroaryl moiety comprised in said -(L2)-heteroaryl group is covalently bonded to the (L2) moiety through a ring carbon atom; (L2) is —O—, —NH—, —N(alkyl)-, alkylene or heteroalkylene; (R1) is a hydrogen bonding group; each (R2) is independently selected from alkyl, alkenyl, alkynyl, cyclyl, amino, amido, C amido, alkylamino, hydroxyl, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, alkoxy, acyl, carboxyl, carbamate or urea; each (R3) is independently selected from alkyl, alkenyl, alkynyl, cyclyl, amino, amido, C-amido, alkylamino, hydroxyl, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, alkoxy, acyl, carboxyl, carbamate, or urea; and n is independently 0, 1, 2, 3 or 4.