Patent ID: 6830929
Filing Date: 2004-12-14
Classification: A61K,C07K,C12N

Abstract:
An infectious particle complex comprising semi-purified or pure SV40 VP1 capsid protein or a mixture of SV40 VP1 capsid protein and at least one other SV40 capsid protein; and a purified recombinant nucleic acid constituent packaged therein, wherein the nucleic acid constituent is selected from the group consisting of:(a) a purified exogenous naked DNA, or a purified exogenous naked DNA encoding an exogenous protein or peptide, or a purified exogenous naked DNA encoding RNA; (b) a vector comprising any of the purified exogenous naked DNAs of (a); (c) a purified exogenous RNA, or a purified exogenous RNA encoding an exogenous protein or peptide; (d) a vector comprising any of the purified exogenous RNAs of (c); and (e) a purified exogenous antisense RNA, purified exogenous ribozyme RNA or a purified exogenous RNA or purified exogenous naked DNA which inhibits or prevents the expression of undesired protein or proteins in a mammalian cell; and further comprising operatively linked elements sufficient for one or more of the following:(i) replication of said constituent; or (ii) expression of said constituent; or in subcase (e) (iii) prevention of expression of said undesired protein or proteins; in said mammalian cell,wherein the recombinant nucleic acid packaged in the infectious particle complex is more infectious relative to unpackaged recombinant nucleic acid.