Patent ID: 6858673
Filing Date: 2005-02-22
Classification: A61K,A61L,A61Q,Y10S

Abstract:
1. A composition for hydrogel substantially soluble in water at an ordinary temperature comprising: a copolymer (A1) having a phosphorylcholine-like group soluble in an aqueous medium, said copolymer (A1) comprising 25 to 97 mol % of unit (a) derived from at least one of compounds represented by the formula (1) having a phosphorylcholine-like group, and 3 to 75 mol % of unit (b) derived from at least one hydrophobic monomer represented by the formula (2); and a polymer (B) other than said copolymer (A1) soluble in an aqueous medium having one or more of hydrophilic groups selected from the soup consisting of a hydroxyl group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, an amide group, an amino group, a dialkylamino group, a trialkylammonium salt group, a trialkylphosphonium salt group and a polyoxyethylene group: wherein X represents a divalent organic residue, Y represents an alkyleneoxy group having 1 to 6 carbon atoms, Z represents a hydrogen atom or a group R wherein R represents a hydrogen atom or a methyl group, L wherein a combination of said copolymer (A1) and said polymer (B) is selected from the group consisting of 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid homopolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-methyl (meth) acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-ethyl(meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-n-butyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl(meth)acrylate copolymer and (meth)acrylic acid-2-ethylhexyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-butyl methacrylate copolymer and (meth)acrylic acid-lauryl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-stearyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-benzyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-butyl (meth)acrylate copolymer and (meth)acrylic acid-styrene copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid homopolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-methyl (meth) acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-ethyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-lauryl (meth)acrylate copolymer and (meth) acrylic acid-n-butyl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-2-ethylhexyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-lauryl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-lauryl (meth)acrylate copolymer and (meth) acrylic acid-stearyl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-benzyl (meth) acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-lauryl (meth)acrylate copolymer and (meth)acrylic acid-styrene copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid homopolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-methyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-ethyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-n-butyl (meth)acrylate copolymer, 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-2-ethylhexyl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-stearyl (meth)acrylate copolymer and (meth) acrylic acid-lauryl (meth)acrylate copolymer, 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-stearyl (meth) acrylate copolymer; 2(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-stearyl (meth)acrylate copolymer and (meth)acrylic acid-benzyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-stearyl (meth)acrylate copolymer and (meth) acrylic acid-styrene copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid homopolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-methyl (meth) acrylate copolymer, 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-ethyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-n-butyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-2-ethylhexyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-benzyl (meth)acrylate copolymer and (meth) acrylic acid-lauryl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-stearyl (meth) acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-benzyl (meth)acrylate copolymer and (meth)acrylic acid-benzyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-benzyl (meth)acrylate copolymer and (meth) acrylic acid-styrene copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-styrene copolymer and (meth) acrylic acid homopolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-styrene copolymer and (meth) acrylic acid-n-butyl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-styrene copolymer and (meth)acrylic acid-2-ethylhexyl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-styrene copolymer and (meth)acrylic acid-lauryl (meth)acrylate copolymer; 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-styrene copolymer and (meth) acrylic acid-stearyl (meth)acrylate copolymer; 2-(meth) acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate-styrene copolymer and (meth)acrylic acid-benzyl (meth)acrylate copolymer; and 2-(meth)acryloyloxyethyl-2′-(trimethylammonio) ethyl phosphate-styrene copolymer and (meth)acrylic acid-styrene copolymer.