Patent ID: 6805880
Filing Date: 2004-10-19
Classification: A61K

Abstract:
A delivery system for oral delivery of the antioxidants vitamin C and vitamin E to obtain high concentrations thereof and a controlled ratio between vitamin C and vitamin E in blood plasma in humans or animals, characterized in that it has a slow release of vitamin C and a plain release of vitamin E;wherein vitamin C is present in an amount in the delivery system so as to deliver a daily dose corresponding to 60 mg-2 g of vitamin C, and vitamin E is present in an amount in the delivery system so as to deliver a daily dose corresponding to 50 mg-500 mg of &agr;-tocopherol, and the antioxidants are present in amounts so as to obtain vitamin C and vitamin E in a ratio in the blood plasma of 1:1 to 3:1; wherein the solubility of vitamin E is such that at least 90% of vitamin E is dissolved in less than 30 minutes under the conditions of Test B; and wherein the solubility of vitamin C is such that less than 40% of vitamin C is dissolved after 1 hour under the conditions of Test A; and wherein said delivery system achieves a concentration of vitamin E in the blood plasma of at least 20 &mgr;mol/liter and a concentration of vitamin C in the blood plasma of at least 40 &mgr;mol/liter.