Patent ID: 6369064
Filing Date: 2002-04-09
Classification: A61P,C07D

Abstract:
A compound of formula (I) wherein:R1 is a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8-cycloalkyl, aryl or a thienyl group, each group being optionally substituted by one or more substituents selected from halogen, OR8, NR9R10, SR11 or C1-6 alkyl (itself optionally substituted by one or more halogen atoms); R2 is C1-8 alkyl, C2-8 alkenyl or C3-8 cycloalkyl each of which may be optionally substituted by one or more substituents selected from halogen, OR8, NR9R10, SR11, C1-6 alkyl, C3-8 cycloalkyl, pyridyl or aryl (the latter two of which may be optionally substituted by one or more substituents selected from halogen, OR20, C(O)R11, NR14C(O)R15, NR16SO2R17, SO2NR18R19, nitro, NR12R13, SR11, methylenedioxy or C1-6 alkyl which is optionally substituted by one or more halogen atoms); R3 and R4 are both hydoxy; R5 is hydrogen or C1-6 alkyl; R6 is C1-6 alkyl, optionally substituted by one or more groups selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, OR21, C3-6 cycloalkyl, or R6 is C3-6 cycloalkyl, or R6 is â€”A-phenyl or â€”A-pyridyl each of which may be optionally substituted by one or more groups selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, OC1-6 alkyl, C3-6 cycloalkyl, or methylenedioxy; or R5 and R6 together with the nitrogen atom to which they are attached for a 5 to 7-membered saturated ring optionally substituted by C1-6 alkyl; A is a bond or C1-6 alkyl; R8 is hydrogen, C1-6 alkyl (which may be optionally substituted by one or more halogen atoms) or aryl (which may be optionally substituted by one or more substituents selected from halogen, nitro, C(O)R11, OR20, SR11, NR12R13,NR14C(O)R15, NR16SO2R17, SO2NR18R19); R9 is hydrogen, C1-4 alkyl (which may be optionally substituted by one or more halogen atoms) or aryl (which may be optionally substituted by one or more substituents selected from halogen, nitro, C(O)R20, OR20, SR11, NR12R13, NR14C(O)R15, NR16SO2R17, SO2NR18R19); R10 is hydrogen, C1-6 alkyl or C(O)C1-6 alkyl; R12 and R13 are independently hydrogen, C1-6 alkyl or together with the nitrogen atom to which they are attached form a 4- to 8-membered ring; R15 is C1-6 alkyl or phenyl; R11, R14 and R16 are independently hydrogen or C1-6 alkyl; R17 is C1-6 alkyl or phenyl; R18 and R19 are independently hydrogen, C1-6 alkyl or phenyl; R20 is hydrogen, phenyl or C1-6 alkyl (which may be optionally substituted by halogen); R21 is hydrogen or C1-6 alkyl, provided that when R21 is H, R5 must be C1-6 alkyl; or a pharmaceutically acceptable salt or solvate thereof.