Patent ID: 7358062
Filing Date: 2008-04-15
Classification: G01N

Abstract:
1. A method for assessing the condition of the gastric mucosa in a subject to diagnose gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum gastritis, atrophic antrum/corpus gastritis and non-atrophic gastritis by assaying (i) pepsinogen I (PGI), (ii) unstimulated gastrin-17 (G17) or stimulated gastrin 17 (stG17) and (iii) a marker for Helicobacter pylon infection (Hp-Marker), the method comprising: (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject; (2) quantitatively measuring the concentration of PGI in said sample from step (1); (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1); (4) determining (5) entering into a data processing system comprising a data storing means or a data display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising: (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result, (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high G17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result, (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an antibody HP-marker comparison result, and (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa condition of said subject according to the following table: and stores or displays said diagnosis information, and (6) using said stored or displayed diagnosis information to diagnose in said subject a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.