Patent ID: 6833452
Filing Date: 2004-12-21
Classification: A61P,C07D

Abstract:
A process for the preparation of crystalline (R,S)-cefuroxime axetil of Formula I: comprising:a. generating an amine salt of cefuroxime in situ by reacting cefuroxime of Formula II, with an amine selected from the group consisting of ethylamine, diethylamine, diisopropylamine, dibutylamine, di-sec-butylamine, triethylamine, dicyclohexylamine, or didecylamine, in an inert organic solvent, b. reacting the amine salt of cefuroxime in situ with (R,S)-1-acetoxyethyl bromide in the presence of a base, and c. followed by aqueous work-up to give crystalline (R,S)-cefuroxime axetil wherein said work-up comprises extracting with an organic solvent followed by the addition of a polar solvent selected from the group consisting of a lower alkanol, ketone, ester and mixtures thereof.