Patent ID: 6524595
Filing Date: 2003-02-25
Classification: A61K,A61P,A61Q,B82Y,C08B

Abstract:
A method of cosmetic care comprising topically delivering on skin zones to which said cosmetic care is sought at least one substituted cyclodextrin in the form of at least one nanoparticle or at least one micelle having the following chemical formula:CD(OH)w(P)x(X)y(M)z where:CD represents a structure based on a non-hydroxyalkylated cyclodextrin without its hydroxyl groups, the cyclodextrin comprising one or more of &agr;-cyclodextrin, &bgr;-cyclodextrin or &ggr;-cyclodextrin, OH represents the free hydroxyl groups of the cyclodextrin, w, x, y, and z are defined such that: when the cyclodextrin is an &agr;-cyclodextrin, x and z are each independently a whole number between 0 and 17, y is a whole number between 1 and 18, and w represents a whole number such that a sum of w+x+y+z is 18, when the cyclodextrin is a &bgr;-cyclodextrin, x and z are each independently a whole number between 0 and 20, y is a whole number between 1 and 21, and w represents a whole number such that a sum of w+x+y+z is 21, when the cyclodextrin is a &ggr;-cyclodextrin, x and z are each independently a whole number between 0 and 23, y is a whole number between 1 and 24, and w represents a whole number such that a sum of w+x+y+z is 24, X represents a substituent having a formula â€”Oâ€”C(&boxH;O)â€”R or â€”N(R1R2) defined below, replacing the â€”OH portion of at least one primary alcohol function and optionally at least one secondary alcohol function; P represents a radical substituting a primary or secondary hydroxyl group selected from the group consisting of a phosphate, an ose and an oside, when at least one X represents Oâ€”C(&boxH;O)â€”R; P represents a radical substituting a primary or secondary hydroxyl group selected rom the group consisting of a sulfate, a phosphate, an ose and an oside, when at least one X represents â€”N(R1R2); when at least one X represents â€”NR1R2, â€”NR1R2 is a radical substituting at least one primary hydroxyl group and optionally at least one secondary hydroxyl group, attached to the cyclodextrin skeleton, in which R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated hydrocarbon radical containing 1 to 30 carbon atoms; when at least one X represents â€”Oâ€”C(&boxH;O)â€”R, â€”Oâ€”C(&boxH;O)â€”R is a radical substituting at least one primary hydroxyl group, and optionally at least one secondary hydroxyl group, or the two, attached to the cyclodextrin skeleton, where R represents a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated hydrocarbon radical containing 1 to 30 carbon atoms; (X)ycan represent a mixture of groups â€”NR1R2 and â€”OCOR substituting at least one primary hydroxyl group and optionally at least one secondary hydroxyl group, or the two; M is a substituent for at least one primary or secondary alcohol function or the two of the cyclodextrin, M is a functional group G1 or a specific radical G2, either directly substituting a primary or secondary alcohol function of the cyclodextrin, or indirectly substituting said primary or secondary alcohol function via a spacer arm W, where: when X is an amine, W is a spacer arm containing 1 to 20 carbon atoms, and includes a functional group selected from the group consisting of acid, sulfonic and phosphoric acid, alkanoyl, alkenyl, alkynyl, aldehyde, amine, amide, azide, acid anhydride, ketone, isocyanate, phenyl, hydroxyl, epoxy, ester, imide, amidine, halide, nitro, nitriles, peroxides, organometallic derivatives, and sulfur-containing derivatives, when X is an ester, W is a spacer arm containing 1 to 20 carbon atoms, and includes a functional group selected from the group consisting of acid, sulfonic and phosphoric acid, alkanoyl, alkenyl, alkynyl, aldehyde, amine, amide, azide, acid anhydride, ketone, isocyanate, phenyl, epoxy, ester, imide, amidine, halide, nitro, nitriles, peroxides, organometallic derivatives, and sulfur-containing derivatives, when X is an amine, G1 represents at least one of the following functions and its derivatives: an acid, a sulfonic, a phosphoric acid, an alkanoyl, an alkenyl, an alkynyl, an aldehyde, an amine, an amide, an azide, an acid anhydride, a ketone, an isocyanate, a phenyl, a hydroxyl, an epoxy, an ester, an imide, an amidine, a halide, a nitro, a nitrile, a peroxide, an organometallic compound, and a sulfur-containing compound; when X is an ester, G1 represents at least one of the following functions and its derivatives: an acid, a sulfonic, a phosphoric acid, an alkanoyl, an alkenyl, an alkynyl, an aldehyde, an amine, an amide, an azide, an acid anhydride, a ketone, an isocyanate, a phenyl, an epoxy, an ester, an imide, an amidine, a halide, a nitro, a nitrile, a peroxide, an organometallic compound, and a sulfur-containing compound; and G2 represents at least one compound selected from the group consisting of a sugar, a polyol, an oligosaccharide, a polysaccharide, a lectin, an amino acid, a peptide, a protein, an antibody, a nucleotide, a nucleoside, an oligonucleotide, an oligonucleoside, a chromophore, a polymer, a sterol, a steroid, a hormone, a flavonoid, a terpene, caffeine, theophylline, nicotinic compound, a vitamin, a vitamin ester, a cholesterol, a phospholipid, a glycolipid, a sphingolipid, a ceramid, a triglyceride, a natural polyphenol, a synthetic polyphenol, an essential oil, a flavoring, a fragrance, a dye, and a cosmetically active substance.