Patent ID: 7232805
Filing Date: 2007-06-19
Classification: A61K,A61P

Abstract:
1. An anti-tumor drug and cobalamin conjugate comprising: a. cobalamin, or a derivative or analogue thereof; b. a linker covalently bound to the 5′-OH moiety of cobalamin or cobalamin derivative; and c. an anti-tumor drug covalently bound to the linker thereby forming the conjugate wherein the drug is cleavable from the linker and/or the linker is cleavable from the drug by an intracellular enzyme; the conjugate is adapted for transport across a cellular membrane after complexation with transcobalamin; the drug is cleavable from the linker and/or the linker is cleavable from the drug by an intracellular enzyme; and the conjugate optionally possesses one or more protecting groups.