Patent ID: 8957252
Filing Date: 2015-02-17
Classification: C07C

Abstract:
1. A process for the preparation of (2R)-2-acetamido-N-benzyl-3-methoxypropanamide, comprising the steps of; a. reacting (2S)-2-bromo-3-hydroxypropanoic acid with benzylamine in the presence of a base and an activator to produce (2S)-N-benzyl-2-bromo-3-hydroxypropanamide; b. reacting (2S)-N-benzyl-2-bromo-3-hydroxypropanamide with sodium azide in a polar aprotic solvent to produce (2R)-2-azido-N-benzyl-3-hydroxypropanamide; c. hydrogenating (2R)-2-azido-N-benzyl-3-hydroxypropanamide to produce (2R)-2-amino-N-benzyl-3-hydroxypropanamide; d. alkylating the hydroxyl group of (2R)-2-amino-N-benzyl-3-hydroxypropanamide to produce (2R)-2-amino-N-benzyl-3-methoxypropan-amide; and e. acetylating the amino group of (2R)-2-amino-N-benzyl-3-methoxypropanamide to produce the compound (2R)-2-acetamido-N-benzyl-3-methoxypropanamide.