Patent ID: 6469033
Filing Date: 2002-10-22
Classification: A61K,A61P,Y02A

Abstract:
A method of treating a human or animal patient in need of treatment for a skin infection, which is caused, at least in part, by at least one antibiotic-resistant bacterium, the method comprising applying to the skin infection of the patient an efficacious amount of at least one compound chosen from 1-hydroxy-2-pyridones of formula I and pharmaceutically acceptable salts thereof: where R1, R2, and R3, which are identical or different, are H or alkyl having 1 to 4 carbon atoms, and R4 is a saturated hydrocarbon radical having 6 to 9 carbon atoms or a radical of formula II: where:X is S or O; Y is H, or up to 2 halogen atoms; Z is a single bond, or a bivalent radical comprising (1) O, or (2) S, or (3) â€”CR2â€”, where R is H or (C1-C4)-alkyl, or (4) from 2 to 10 carbon atoms linked in the form of a chain, which optionally further comprises one or more of the following: (i) a carbon-carbon double bond, or (ii) O, S, or a mixture thereof, wherein if 2 or more O or S atoms or a mixture thereof are present, each O or S atom is separated by at least 2 carbon atoms; and, in any of the foregoing bivalent radicals, the free valences of the carbon atoms of said bivalent radical are saturated by H, (C1-C4)-alkyl, or a mixture thereof; and Ar is an aromatic ring system having one or two rings, wherein the system is unsubstituted or substituted by one, two, or three radicals, which are identical or different, and are chosen from halogen, methoxy, (C1-C4)-alkyl, trifluoromethyl, and trifluoromethoxy.