Patent ID: 6699859
Filing Date: 2004-03-02
Classification: A61P,C07D

Abstract:
A compound of formula I, or a salt thereof: whereinthe ring formed by Q together with the N to which Q is attached represents azetidine, pyrrolidine, piperidine, morpholine or thiomorpholine ring, optionally substituted C1-6 alkyl, R1 represents C3-7cycloalkyl, phenyl, furyl, thienyl or pyridinyl, any of which groups may be optionally substituted with one or two substituents, each substituent independently is C1-6alkyl, aryl(C1-6)alkyl, pyridyl(C1-6)alkyl, halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, hydroxy, hydroxymethyl, C1-6alkoxy, C3-7cycloalkyl(C1-6)alkoxy, C3-7cycloalkoxy, amino(C1-6)alkyl, di(C1-6)alkylamino(C1-6)alkyl, di(C1-6) alkylaminocarbonyl(C1-6)alkyl, N-(C1-6)alkylpiperidinyl, pyrrolidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, di(C1-6)alkylmorpholinyl(C1-6)alkyl or imidazolyl(C1-6)alkyl; and R2 represents cyano(C1-6)alkyl, hydroxy(C1-6)alkyl, C3-7cycloalkyl(C1-6) alkyl, propargyl, azetidinylcarbonyl(C1-6)alkyl, pyrrolidinylcarbonyl(C1-6)alkyl, piperidinylcarbonyl(C1-6)alkyl, piperazinylcarbonyl(C1-6)alkyl, morpholinylcarbonyl(C1-6)alkyl, thiomorpholinylcarbonyl(C1-6)alkyl, aryl(C1-6)alkyl, pyridinyl(C1-6)alkyl, quinolinyl(C1-6)alkyl, isoquinolinyl(C1-6)alkyl, pyridazinyl(C1-6)alkyl, pyrimidinyl(C1-6) alkyl, pyrazinyl(C1-6)alkyl, quinoxalinyl(C1-6)alkyl, furyl(C1-6)alkyl, benzofuryl(C1-6)alkyl, dibenzofuryl(C1-6)alkyl, thienyl(C1-6)alkyl, benzthienyl(C1-6)alkyl, pyrrolyl(C1-6)alkyl, indolyl(C1-6)alkyl, pyrazolyl(C1-6)alkyl, indazolyl(C1-6)alkyl, oxazolyl(C1-6)alkyl, isoxazolyl(C1-6)alkyl, thiazolyl(C1-6)alkyl, isothiazolyl(C1-6)alkyl, imidazolyl(C1-6)alkyl, benzimidazolyl(C1-6)alkyl, oxadiazolyl(C1-6)alkyl, thiadiazolyl(C1-6)alkyl, triazolyl(C1-6)alkyl, or tetrazolyl(C1-6)alkyl, any of which groups may be optionally substituted with one or two substituents, each substituent independently is C1-6alkyl, aryl(C1-6)alkyl, pyridyl(C1-6)alkyl, halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, hydroxy, hydroxymethyl, C1-6)alkoxy, C3-7cycloalkyl(C1-6)alkoxy, C3-7cycloalkoxy, amino(C1-6)alkyl, di(C1-6) alkylamino(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, N-(C1-6)alkylpiperidinyl, pyrrolidinyl(C1-6)alkyl, piperazinyl(C1-6)alkyl, morpholinyl(C1-6)alkyl, di(C1-6)alkylmorpholinyl(C1-6)alkyl or imidazolyl(C1-6)alkyl.