Patent ID: 8278308
Filing Date: 2012-10-02
Classification: A61K,A61P,C07D,Y02P

Abstract:
1. A method for delivery of a biologically active agent comprising: administering to a patient in need of treatment therewith an effective amount of a biologically active agent in the form of microparticles, said microparticles comprising a pharmaceutically acceptable salt of a diketopiperazine and the biologically active agent; wherein said microparticles release said biologically active agent upon administration; and wherein said pharmaceutically acceptable salt of the diketopiperazine has the structure according to Formula 1: wherein Formula 1 is a diketopiperazine selected from the following compounds: 3,6-di(4-aminobutyl)-2,5-diketopiperazine, 3,6-di(succinyl-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(maleyl-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(citraconyl-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(glutaryl-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(malonyl-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(oxalyl-4-aminobutyl)-2,5-diketopiperazine, and 3,6-di(fumaryl-4-aminobutyl)-2,5-diketopiperazine; and said salt further comprises at least one cation.