Patent ID: 6177100
Filing Date: 2001-01-23
Classification: A61K,A61Q,B82Y,Y10S

Abstract:
A cosmetic or pharmaceutical composition for the treatment of the hair and scalp consisting essentially of a continuous aqueous phase containing vesicles and at least one of a cationic surface active agent and a quaternized protein, said vesicles consisting essentially of a non-ionic amphiphilic lipid material which form a hydrated lipidic lamellar phase in the form of said vesicles, which are insoluble in water, said nonionic amphiphilic lipid material being selected from the group consisting of linear or branched ethers or esters of polyglycerol having the respective formulas(II) and (III): ##STR10##whereinn ha statistical average value between 2 and 6 andR.sub.5 is:either (1) an R.sub.6 aliphatic chain or R'.sub.6 or R.sub.6 CO radical, R.sub.6 being a linear or branched aliphatic radical having 11-17 carbon atoms or (2) a radical ##STR11##wherein R.sub.7 and R.sub.8 are R.sub.6 or R'.sub.6 radicals, identical or different, R.sub.6 and R'.sub.6 having the meanings given above, said nonionic amphiphilic lipid material being present in an amount ranging from 0.1 to 20 weight percent based on the total weight of said composition; said at least one cationic surface active agent having the formula: ##STR12##whereinX is chloride or CH.sub.3 SO.sup..crclbar..sub.4 and R.sub.1 is a C.sub.1 -C.sub.4 alkyl radical and in which;(a) when X is chloride:either R.sub.2 and R.sub.3 are C.sub.1 -C.sub.4 alkyl radicals, identical or different from R.sub.1 and each other, and R.sub.4 is C.sub.16 -C.sub.22 alkyl radical;or R.sub.2 =R.sub.1 and, in this case:either R.sub.3 =R.sub.4 =C.sub.18 alkyl;or R.sub.3 =(C.sub.17 alkyl)amidopropyl aid R.sub.4 =(C.sub.14 alkyl) acetate and(b) when X is CH.sub.3 SO.sup..theta..sub.4 :R.sub.2 represents a radical selected from the group consisting of an alkyl alkenyl amidoethyl radical and an alkenyl amidoethyl radical, in which the alkyl and alkenyl radical contains 13-21 carbon atoms and is derived from fatty acids of tallow, andR.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form a substituted 4,5-dihydroxyimidazol ring substituted in position 2, said cationic surface active agent being present in an amount ranging from 0.05 to 10 weight percent based on the total weight of said composition; andsaid at least one quaternized protein constituted by a chemically modified polypeptide having at least one quaternary ammonium group having at least one C.sub.1 -C.sub.18 alkyl chain, the polypeptide being selected from the hydrolyzates of animal protein, said quaternized protein being present in an amount ranging 0.05 to 3 weight percent based on the total weight of said composition;wherein said dispersion is formed by a process comprising preparing, separately, composition of said vesicles in a continuous phase and a composition of an aqueous phase containing said at least one of a cationic surface active agent and a quaternized protein, and mixing said composition of vesicles and said composition of an aqueous phase such that said vesicles are dispersed in said continuous phase containing at least one of said cationic surface active agent and said quaternized protein.