Patent ID: 8524195
Filing Date: 2013-09-03
Classification: A61B,A61K,B82Y,C01G,C01P,C09C,Y10S,Y10T

Abstract:
1. A method for preparing iron oxide nano contrast agents, comprising the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer solution to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe wherein the pH of the acidic buffer solution is 2 to 5.