Patent ID: 9023822
Filing Date: 2015-05-05
Classification: A61K,A61P,C12N

Abstract:
1. A method of upregulating a function of and/or the expression of an ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide selected from SEQ ID NO: 1 or a variant thereof in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded modified antisense oligonucleotide of 12 to 25 nucleotides in length that specifically targets a complementary region of a natural antisense polynucleotide of the ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide selected from SEQ ID NO: 2 ; thereby upregulating a function of and/or the expression of the ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide in patient cells or tissues in vivo or in vitro.