Patent ID: 7615214
Filing Date: 2009-11-10
Classification: A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method of treating a disease in which the morbid state progresses by abnormal angiogenesis, comprising administering to a human or an animal in need of such treatment an effective amount of a recombinant monoclonal antibody selected from the group consisting of a humanized antibody and an antibody fragment thereof, said recombinant monoclonal antibody specifically binding to the human VEGF receptor Flt-1, and wherein the recombinant monoclonal antibody binds to an epitope present in a region of the 100 said recombinant monoclonal antibody comprises an antibody heavy chain (H chain) variable region (V region), and an antibody light chain (L chain) variable region (V region), and wherein said H chain V region comprises the amino acid sequence of SEQ ID NO:91.