Patent ID: 6706933
Filing Date: 2004-03-16
Classification: C07B,C07C

Abstract:
A method for making aromatic compounds having the formula, where R is a hydrogen atom, a halogen atom, CF3, a fused aryl, a C1-C20 alkyl, amino, nitro, a C1-C10 ether or thioether, C1-C10 ester, a heteroaryl or aryl and said method comprising:(a) mixing a deoxofluorinating agent with a difluoroketone derivative of an aromatic compound in a solvent to form a tetrafluoro derivative of an aromatic compound, said difluoroketone compound having one, two or three rings, said rings being separate or fused and said rings optionally containing one or more heteroatoms and one or more substitutions in addition to hydroxy, said difluoroketone derivative having both fluorine atoms on a carbon vicinal to the ketone; (b) mixing the tetrafluoro derivative of an aromatic compound of (a) in an organic solvent with a reducing agent in aqueous ammonia to form an aromatic compound containing two vicinal fluorine atoms.