Patent ID: 7303763
Filing Date: 2007-12-04
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition in a solid oral dosage form comprising: a core containing a therapeutically effective amount of at least one conjugated estrogen, or a component thereof, and at least one organic excipient, wherein the at least one organic excipient comprises less than about 25% w/w of a cellulose ingredient, and less than about 50% w/w of a sugar ingredient, and at least one inorganic excipient, wherein the at least one inorganic excipient comprises a calcium phosphate tribasic ingredient in an amount of less than about 20% w/w; and a pharmaceutically acceptable coating that is free of hormones, wherein the composition does not crack when stored at 40° C. and 75% relative humidity for about two months.