Patent ID: 8883977
Filing Date: 2014-11-11
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A purified antibody or an antigen-binding fragment thereof, comprising at least one antigen-binding site including an immunoglobulin heavy chain variable region (VH) domain and an immunoglobulin light chain variable region (VL) domain, the heavy chain variable region domain containing hypervariable regions, CDR1, CDR2 and CDR3, in a sequence thereof, wherein the CDR1 consists of SHDMS (SEQ ID NO: 4), the CDR2 consists of AINSDGDNTYYPDTMER (SEQ ID NO: 5), and the CDR3 consists of LTLRNWYFDV (SEQ ID NO: 6), the light chain variable region domain containing hypervariable regions, CDR1′, CDR2′ and CDR3′, in a sequence thereof, wherein the CDR1′ consists of KSSQSLLYSTNQQNYLA (SEQ ID NO: 7), the CDR2′ consists of WASTRES (SEQ ID NO: 8), and the CDR3′ consists of QQYYRYPPT (SEQ ID NO: 9).