Patent ID: 6080760
Filing Date: 2000-06-27
Classification: C07D

Abstract:
A compound of the formula: ##STR34## wherein Q is ##STR35## R.sup.1 is selected from unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, CF.sub.3, cyano, nitro, N(R.sup.17).sub.2, NR.sup.17 COR.sup.18, NR.sup.17 CON(R.sup.18).sub.2, NR.sup.17 SO.sub.2 R.sup.7, NR.sup.17 SO.sub.2 N(R.sup.18)2, OR.sup.7, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.17, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.17) .sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.7 or C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl wherein the substituents on the pyridyl, pyrazinyl, thienyl, thiazolyl, furanyl, quinazolinyl or naphthyl are independently selected from CF.sub.3, cyano, nitro, N(R.sup.17).sub.2, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.17, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.7).sub.2, phenyl, OR.sup.7, halogen, C.sub.1-4 alkyl or C.sub.3-8 cycloalkyl;R is selected from hydrogen, cyano, OR.sup.7, CO.sub.2 R.sup.17, CON(R.sup.17).sub.2, SO.sub.2 R.sup.7, SO.sub.2 N(R.sup.17).sub.2, tetrazole, isooxadiazole, unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, cyano, nitro, OR.sup.7, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.17, (CH.sub.2).sub.0-4 CON (R.sup.17).sub.2, (R.sup.17).sub.2, NR.sup.17 COR.sup.7, NR.sup.17 CON(R.sup.18).sub.2, NR.sup.17 SO.sub.2 R.sup.7, NR.sup.17 SO.sub.2 N(R.sup.18).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sub.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.7 or C.sub.1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, thienyl, furanyl or naphthyl wherein the substituents on the pyridyl, thienyl, furanyl or naphthyl are independently selected from CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.17, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.17).sub.2,(CH.sub.2).sub.0-4 SO.sub.2 R.sup.7, phenyl, OR.sup.7, halogen, C.sub.1-4 alkyl or C.sub.3-8 cycloalkyl;E, G, L and M are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.7, (CH.sub.2).sub.0-4 N(R.sup.17).sub.2, (CH.sub.2).sub.0-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.17 or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.17).sub.2 ;J is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.1-4 OR.sup.7, (CH.sub.2).sub.1-4 N(R.sup.17).sub.2, (CH.sub.2).sub.1-4 CN, (CH.sub.2).sub.0-4 CF.sub.3, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 SO.sub.2 R.sup.17 or (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.17).sub.2 ;R.sup.2, R.sup.3 and R.sup.6 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.4-8 cycloalkyl, (CH.sub.2).sub.0-4 CO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 CON(R.sup.17).sub.2, (CH.sub.2).sub.0-4 COR.sup.7, (CH.sub.2).sub.2-4 OR.sup.7, (CH.sub.2).sub.1-4 CF.sub.3, (CH.sub.2).sub.1-4 SO.sub.2 R.sup.7, (CH.sub.2).sub.0-4 SO.sub.2 N(R.sup.17).sub.2 or (CH.sub.2).sub.1-4 CN;R.sup.7 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.8, R.sup.9, R.sup.10, R.sup.14, R.sup.15 and R.sup.16 are each independently selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.7 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.13 is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.2-4 OR.sup.7, OR.sup.7 or (CH.sub.2).sub.0-4 CF.sub.3 ;R.sup.17 and R.sup.18 are each independently selected from is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl or (CH.sub.2).sub.1-4 CF.sub.3 ;R.sup.26 is selected from hydrogen or OR.sup.28 ;R.sup.28 is selected from hydrogen, C.sub.1-8 alkl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.7 or (CH.sub.2).sub.0-4 CF.sub.3 ;each X is independently selected from halogen, cyano, nitro, C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, (CH.sub.2).sub.0-4 OR.sup.7 or (CH.sub.2).sub.0-4 CF.sub.3 ;m, p and q are each independently an integer of from zero to two, provided that when q is zero, R.sup.26 is hydrogen; andn, o, and s are each independently an integer of from zero to four;or a pharmaceutically acceptable salt thereof.