Patent ID: 6730486
Filing Date: 2004-05-04
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
Human &bgr;TrCP protein (h-&bgr;TrCP) for the targeting of proteins towards proteasome degradation pathways, said protein having SEQ ID NO:2 and being capable of interacting with proteins degradable by proteasome, which possess the phosphorylation unit comprising the amino acids Asp-Ser-Glu-Xaa-Xaa-Ser (SEQ ID NO:9), in which Xaa is any natural amino acid and the serine residues are phosphorylated and said protein comprising the following units having the following positions in the sequence SEQ ID NO:2:F-box:amino acids 147-191,first WD unit:amino acids 259-292,second WD unit:amino acids 304-332,third WD unit:amino acids 343-373,fourth WD unit:amino acids 387-415,fifth WD unit:amino acids 427-455,sixth WD unit:amino acids 467-492, andseventh WD unit:amino acids 516-544.