Patent ID: 8697389
Filing Date: 2014-04-15
Classification: B82Y,G01N

Abstract:
1. A method for labeling and imaging cells comprising: contacting the cells with a labeling agent comprising a perfluorocarbon nanoemulsion containing optical quantum dot nanoparticles, a perfluorocarbon continuous phase and lipid liposomes, wherein the lipid liposomes encapsulate the optical quantum dot nanoparticles dispersed in the perfluorocarbon continuous phase; and imaging the resultant labeled cells, wherein, the optical quantum dot nanoparticles are surface reformed by coating the surface of the optical quantum dot nanoparticles with a surface reforming perfluorocarbon selected from the group consisting of a perfluorocarbon having a thiol end group, a perfluorinated alcohol phosphate ester and its salt, a perfluorinated sulfonamide alcohol phosphate ester and its salt, a perfluorinated alkyl sulfonamide alkylene quaternary ammonium salt, and a N,N-(carboxyl-substituted lower alkyl) perfluorinated alkyl sulfonamide.