Patent ID: 8106069
Filing Date: 2012-01-31
Classification: A61P,C07D

Abstract:
1. A method for inhibiting protein kinase activity of a kinase selected from the group consisting of cdk2/cyclin A, E, B1, D1, MAPK, EGFR, PKA, Cdk5/p25, IGF1-R, Aurora-2 or Cdc7/dbf4, ACK1, BRK, JAK2, MELK MPS1, NEK6, PDGFR, PDK1, PLK1, RET, ABL, AKT1, AKT2, AKT3, AUR2, IGFR1, IR, LCK, and combinations thereof, which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) wherein R is selected from the group consisting of —R R wherein R or isomers, tautomers or a pharmaceutically acceptable salt thereof.