Patent ID: 6946257
Filing Date: 2005-09-20
Classification: A01K,C07K

Abstract:
1. A method for identifying an agent that decreases hedgehog signal transduction for ameliorating an effect of loss of function of a patched gene in a mammalian cell, comprising: (i) contacting a hedgehog protein with a mammalian cell in culture that expresses a wild-type patched protein, (ii) contacting one or more test agents with said mammalian cell, and (iii) identifying one or more of said test agents that decrease the level of hedgehog signal transduction stimulated by said hedgehog protein relative to that present in the absence of said one or more test agents, wherein an agent that decreases hedgehog signal transduction is useful for ameliorating an effect of a loss of patched-mediated hedgehog signal transduction in a mammalian cell.