Patent ID: 6245748
Filing Date: 2001-06-12
Classification: A61K,A61P,C12N

Abstract:
A method of inhibiting expression of fibroblast growth factor binding protein (FGF-BP) in a cell in vitro by administration of FGF-BP ribozymes which cleave FGF-BP mRNA, wherein said ribozymes are hammerhead ribozymes as depicted in (FIG. 1) having a target cleavage site selected from the group consisting of 258, 332 and 697 nucleotides downstream of the translation initiation site of FGF-BP mRNA, and wherein said ribozymes comprise antisense sequences 5' and 3' to the ribozyme catalytic center that direct the ribozymes to said target cleavage site, such that expression of FGF-BP is inhibited.