Patent ID: 6458814
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound according to formula (I): wherein:Y is CRâ€²Râ€² or NRâ€²C(O); R1 is â€”C0-6alkyl-Ar, H, â€”C1-6alkyl, â€”CN or â€”S(O)kRg; R2 is W is â€”(CHRg)aâ€”Uâ€”(CHRg)bâ€”; U is absent or CO, CRg2, C(&boxH;CRg2), S(O)k, O, NRg, CRgORg, CRg(ORk)CRg2, CRg2CRg(ORk), C(O)CRg2, CRg2C(O), CONRi, NRiCO, OC(O), C(O)O, C(S)O, OC(S), C(S)NRg, NRgC(S), S(O)2NRg, NRgNRg, NRgCRg2, CRg2NRg, CRg2O, OCRg2, Câ‰¡C, CRg&boxH;CRg, or Ar; Rg is H, C1-6alkyl, C3-7cycloalkyl-C0-6alkyl or Arâ€”C0-6alkyl; Rk is Rg, â€”C(O)Rg, or â€”C(O)ORf; Ri is is H, C1-6alkyl, C3-7cycloalkyl-C0-6alkyl, Arâ€”CO0-6alkyl, or C1-6alkyl substituted by one to three groups chosen from halogen, CN, NRg2, ORg, SRg, CO2Rg, and CON(Rg)2; Rf is H, C1-6alkyl or Arâ€”CO0-6alkyl; Re is H, C1-6alkyl, Arâ€”C0-6alkyl, C3-7cycloalkyl-C0-6alkyl, or (CH2)kCO2Rg; Rb and Rc are independently selected from H, C1-6alkyl, Arâ€”CO0-6alkyl, Het-C0-6alkyl, or C3-6cycloalkyl-C0-6alkyl, halogen, CF3, ORf, S(O)kRf, CORf, NO2, N(Rf)2, CO(NRf)2, CH2N(Rf)2, or Rb and Rc are joined together to form a five or six membered aromatic or non-aromatic carbocyclic ring, optionally substituted by up to three substituents chosen from halogen, CF3, C1-4alkyl, ORf, S(O)kRf, CORf, CO2Rf, OH, NO2, N(Rf)2, CO(NRf)2, and CH2N(Rf)2; or methylenedioxy; Q1, Q2, Q3 and Q4 are independently Câ€”Ry; Râ€² is H, C1-6alkyl, Arâ€”C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; Râ€³ is Râ€², â€”C(O)Râ€² or â€”C(O)ORâ€²; Ry is H, halo, â€”ORg, â€”SRg, â€”CN, â€”NRgRk, â€”NO2, â€”CF3, CF3S(O)râ€”, â€”CO2Rg, â€”CORg or â€”CONRg2, or C1-6alkyl optionally substituted by halo, â€”ORg, â€”SRg, â€”CN, â€”NRgRâ€³, â€”NO2, â€”CF3, Râ€²S(O)râ€”, â€”CO2Rg, â€”CORg or â€”CONRg2; a is 0, 1 or 2; b is 0, 1 or 2; k is 0, 1 or 2; r is 0, 1 or 2; s is 0, 1 or 2; u is 0 or 1; and v is 0 or 1; or a pharmaceutically acceptable salt thereof.