Patent ID: 8748125
Filing Date: 2014-06-10
Classification: A61P,C07C,C07D,C07F,C12N

Abstract:
1. A method of modulating the expression of a target gene in a host cell, wherein said host cell includes a first gene expression cassette comprising a first polynucleotide encoding a first polypeptide comprising: (i) a transactivation domain; (ii) a DNA-binding domain; and (iii) a Group H nuclear receptor ligand binding domain; a second gene expression cassette comprising: (i) a response element capable of binding to said DNA binding domain; (ii) a promoter that is activated by said transactivation domain; and (iii) said target gene; the method comprising contacting said host cell with a compound of the formula: wherein X and X′ are independently O or S; Y is: (a) substituted or unsubstituted phenyl wherein the substituents are independently 1-5 H, (C (b) substituted or unsubstituted 2-pyridyl, 3-pyridyl, or 4-pyridyl, wherein the substituents are independently 1-4 H, (C R R R R R R