Patent ID: 6689782
Filing Date: 2004-02-10
Classification: A61K,C07D

Abstract:
A compound having the chemical formula: or a pharmaceutically acceptable salt thereof, wherein:A1 is carbon or nitrogen, provided that when A1 is nitrogen, R5 does not exist; R2 and R3 are independently selected from the group consisting of hydrogen, halo and â€”O(1C-4C)alkyl; R4 and R6 are independently selected from the group consisting of hydrogen, halo, â€”O(1C-4C)alkyl, â€”OCF3, and Oâ€”CH2(3C-6C)cycloalkyl; R5 is selected from the group consisting of hydrogen and R7 and R8 are independently selected from the group consisting of hydrogen, halo, â€”Câ‰¡N, â€”O(1C-4C)alkyl, â€”OCHF2, â€”OCF3 and, taken together, â€”OCH2Oâ€”; R1 is selected from the group consisting of -(1C-4C)alkyl, -(3C-6C)cycloalkyl, â€”CH2(3C-6C)alkyl and â€ƒwherein: A4 is selected from the group consisting of â€”NH, oxygen and sulfur; A2, A3 and A5 are independently selected from the group consisting of carbon and nitrogen provided that no more than two of A2, A3 and A5 are nitrogen at the same time; or,R1 is â€”C(O)(CH2)n(R22)R9, wherein, n is 0, 1, 2 or 3; R9 is selected from the group consisting of hydrogen, â€”OH, â€”(1C-4C)alkyl, -(3C-6C)cycloalkyl, â€”CH2(3C-6C)cycloalkyl, wherein:A6, A7 and A8 are independently selected from the group consisting of carbon, oxygen, sulfur and NR15; A9, A10 and A11 are independently selected from the group consisting of carbon and nitrogen; R10 and R11 are independently selected from the group consisting of hydrogen, -(1C-4C)alkyl, â€”SO2R16, â€”C(O)R16 and â€”C(O)OR16, wherein: R16 is selected from the group consisting of hydrogen and -(1C-4C)alkyl wherein the alkyl group may be substituted with 1, 2, 3, or 4 fluorines; R12 is selected from the group consisting of hydrogen, -(1C-4C)alkyl, -(3C-6C)cycloalkyl, â€”CH2(3C-6C)cycloalkyl, â€”C(O)O-(1C-4C)alkyl, â€”SO2R17 and â€”SO2NR18R19, wherein, R17, R18 and R19 are independently selected from the group consisting of hydrogen and -(1C-4C)alkyl; R14 and R15 are independently selected from the group consisting of hydrogen, -(1C-4C)alky and â€”NR10 R11; R22 is selected from the group consisting of hydrogen and (1C-4C)alkyl; or,R9 is â€”C(R16)(R20)(CH2)pNR10R11, wherein: p is 0, 1 or 2; R20 is selected from the group consisting of hydrogen and -(1C-4C)alkyl, the alkyl group being optionally substituted with an entity selected from the group consisting of â€”OH, â€”O(1C-4C)alkyl, â€”Câ‰¡N, â€”SO2(1C-4C)alkyl and and, the compound comprises a racemic mixture, a pure enantiomer or a pure atropisomer of either the racemic mixture or the pure enantiomer.