Patent ID: 6462034
Filing Date: 2002-10-08
Classification: C07C,C07D

Abstract:
A compound of the formula: wherein each Ar independently represents aryl, heterocyclyl or heteroaryl group; wherein when Ar is an aryl group, said aryl group is an unsaturated aromatic carbocyclic group of from 6 to 20 carbon atoms having a single ring or multiple condensed rings, wherein said aryl group may be substituted with 1 to 5 substituents selected from the group consisting of acyloxy, hydroxy, thiol, acyl, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, substituted alkyl, substituted alkoxy, substituted alkenyl, substituted alkynyl, substituted cycloalkyl, substituted cycloalkenyl, aminoacyl, acylamino, alkaryl, aryl, aryloxy, azido, carboxyl, carboxyl alkyl, carboxyl substituted alkyl, carboxyl cycloalkyl, carboxyl substituted cycloalkyl, carboxyl aryl, carboxyl heteroaryl, carboxyl heterocyclic, oxycarbonyl alkyl, oxycarbonyl substituted alkyl, oxycarbonyl cycloalkyl, oxycarbonyl substituted cycloalkyl, oxycarbonyl aryl, oxycarbonyl heteroaryl, oxycarbonyl heterocyclic, cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, aminoacyloxy, oxyacylamino, thioalkoxy, substituted thioalkoxy, thioaryloxy, thioheteroaryloxy, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-aryl, â€”SO-heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, trihalomethyl, NRaNRb, wherein Ra and Rb may be the same or different and are chosen from hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl and heterocyclic; wherein when Ar is a heterocyclyl group, said group is a saturated or unsaturated group having a single ring, multiple condensed rings or multiple covalently joined rings from 1 to 40 carbon atoms and from 1 to 10 hetero ring atoms selected from nitrogen, sulfur, phosphorous and oxygen, wherein said group may be substituted with 1 to 5 substituents selected from the group consisting of alkoxy, substituted alkoxy, cycloakyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, acyl, acylamino, acyloxy, aminoacyl, aminoacyloxy, oxyaminoacyl, cyano, halogen, hydroxyl, keto, thioketo, carboxyl, carboxyl alkyl, carboxyl substituted alkyl, carboxyl cycloalkyl, carboxyl substituted cycloalkyl, carboxyl aryl, carboxyl heteroaryl, carboxyl heterocyclic, oxycarbonyl alkyl, oxycarbonyl substituted alkyl, oxycarbonyl cycloalkyl, oxycarbonyl substituted cycloalkyl, oxycarbonyl aryl, oxycarbonyl heteroaryl, oxycarbonyl heterocyclic, thioaryloxy, thioheteroaryloxy, thioheterocyclooxy, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, hydroxyamino, alkoxyamino, nitro, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-aryl, â€”SO-heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, trihalomethyl, NRaNRb, wherein Ra and Rb may be the same or different and are chosen from hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl and heterocyclic; wherein when Ar is a heteroaryl group, said group is an aromatic group of from 1 to 15 carbon atoms and 1 to 4 heteroatoms selected from oxygen, nitrogen, and sulfur, wherein said group may include from 1 to 5 substituents selected from the group consisting of acyloxy, hydroxy, thiol, acyl, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, substituted alkyl, substituted alkoxy, substituted alkenyl, substituted alkynyl, substituted cycloalkyl, substituted cycloalkenyl, aminoacyl, acylamino, alkaryl, aryl, aryloxy, azido, carboxyl, carboxyl alkyl, carboxyl substituted alkyl, carboxyl cycloalkyl, carboxyl substituted cycloalkyl, carboxyl aryl, carboxyl heteroaryl, carboxyl heterocyclic, oxycarbonyl alkyl, oxycarbonyl substituted alkyl, oxycarbonyl cycloalkyl, oxycarbonyl substituted cycloalkyl, oxycarbonyl aryl, oxycarbonyl heteroaryl, oxycarbonyl heterocyclic, cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, aminoacyloxy, oxyacylamino, thioalkoxy, substituted thioalkoxy, thioaryloxy, thioheteroaryloxy, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-aryl, â€”SO-heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, trihalomethyl, mono-and dialkylamino, mono- and NRaNRb, wherein Ra and Rb may be the same or different and are chosen from hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl and heterocyclic; each R1 and R2 is independently selected from the group consisting of hydrogen, alkyl and substituted alkyl; Q and Qâ€², together with the nitrogen atoms to which they are bound, form a group of the formula: and pharmaceutically acceptable salts thereof.