Patent ID: 8999382
Filing Date: 2015-04-07
Classification: A61K,A61P

Abstract:
1. A drug delivery system for administration of at least one pharmaceutically active substance having a solubility per se in water of less than about 100 μg/ml, said substance being in particulate form with an effective average particle size of less than about 100 nm, wherein the substance particles are essentially amorphous; the substance particles are entrapped in nanoparticles formed of a sodium salt of the methyl ester of N-all-trans-retinoyl cysteic acid, sodium salt of methyl ester of N-13-cis-retinoyl cysteic acid, or a combination thereof; the weight-to-weight ratio of said sodium salt of methyl ester of N-all-trans-retinoyl cysteic acid, sodium salt of methyl ester of N-13-cis-retinoyl cysteic acid, or a combination thereof, to said substance is in the range from about 0.5:1 to about 20:1; and said substance is an immunosuppressant chosen from among ciclosporin, sirolimus, tacrolimus and derivatives thereof.