Patent ID: 6258371
Filing Date: 2001-07-10
Classification: A61L

Abstract:
A method of coating a biocompatible medical article having a polymeric surface, comprising:providing the medical article;cleaning the polymeric surface;synthesizing, in an organic solvent and apart from the medical article, a mixture comprising a first hydrophobic monomer selected from the group consisting of hydrophobic methacrylate monomers and hydrophobic acrylate monomers, a second functional monomer having pendant chemically reactive amine groups capable of forming co-valent bonds with biologically active compounds, and a third hydrophillic monomer, the synthesis yielding a copolymer solution;coating the polymeric surface of the medical article with the copolymer solution to produce a coated copolymeric surface; andcoupling a biomolecule onto the coated surface through the ordered steps of: (a) admixing heparin with a periodate solution to produce an admixture, (b) reacting the admixture and adding cyanoborohydride thereto produce a reacted admixture, (c) diluting the reacted admixture to form a diluted reacted admixture, and (d) treating the coated copolymeric surface with the diluted reacted admixture to render the resulting treated and coated polymeric surface amphiphobic.