Patent ID: 6440975
Filing Date: 2002-08-27
Classification: A61P,C07D

Abstract:
A compound of formula I where R is tetrazolyl, cyano or a radical where R1 has the following meanings: b) succinimidyl; d) a radical â€ƒwhere k is 0, 1 or 2, p is 1, 2, 3 or 4, and R9 is C1-C4-alkyl, C3-C7-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl or phenyl which is unsubstituted or substituted by one or more of the following radicals: halogen, nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, C1-C4-alkylthio, mercapto, amino, C1-C4-alkylamino and C1-C4-dialkylamino; e) a radical OR10, where R10 is: hydrogen, an alkali metal cation or an alkaline earth metal cation, ammonium or a physiologically tolerated alkylammonium ion, C3-C8-cycloalkyl; C1-C8-alkyl; benzyl which is unsubstituted or substituted by one or more of the following radicals: halogen, nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, mercapto, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino; C3-C6-alkenyl or C3-C6-alkynyl, which is unsubstituted or carries one to five halogen atoms; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or from one to three of the following radicals: nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, mercapto, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino; f) a radical â€ƒwhere R11 is: C1-C4-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, C3-C8-cycloalkyl, which radicals are unsubstituted or carry a C1-C4-alkoxy, C1-C4-alkylthio and/or phenyl radical; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, mercapto, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino; g) a radical â€ƒwhere R12 is C1-C4-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, C3-C8-cycloalkyl, which radicals are unsubstituted or carry a C1-C4-alkoxy, C1-C4-alkylthio and/or phenyl radical; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, mercapto, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino; h) a radical â€ƒwhere R13 and R14, independently of one another, are hydrogen, C1-C7-alkyl, C3-C7-cycloalkyl, C3-C7-alkenyl, C3-C7-alkynyl, benzyl or phenyl which are unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, mercapto, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino; or R13 and R14 together form a C4-C7-alkylene chain or a chain consisting of 4 to 7 methylene members and one member selected from the group of oxygen, nitrogen and sulfur, which chain is unsubstituted or substituted by C1-C4-alkyl; tetrazole or nitrile; and W is nitrogen; R2 is hydrogen, halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, hydroxyl, mercapto, C1-C4-alkylthio, nitro, amino, C1-C4-alkylamino or C1-C4-dialkylamino, cyano, phenyl which is unsubstituted or carries one to three of the following: halogen, hydroxyl, amino, mono-(C1-C3)-amino, dialkyl-(C1-C3)-amino, C1-C3-alkyl, C1-C3-alkoxy, mercapto and C1-C3-alkylthio; or X is CR15 where R15 is hydrogen or C1-C5-alkyl, C1-C5-alkoxy, C1-C5-alkylthio, nitro, phenyl, hydroxyl, mercapto, halogen, amino, C1-C4-alkylamino, C1-C4-dialkylamino or cyano, or R15 and R2 to form a 5- to 6-membered alkylene or alkylidene ring or a 5- or 6-membered alkylene or alkenylene ring wherein one or two carbon ring members are replaced by a nitrogen, sulfur or oxygen atom, and which ring is unsubstituted or carries one to three of the following radicals: halogen, nitro, cyano, hydroxyl, mercapto, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-alkylthio, amino, C1-C3-alkylamino and C1-C3-dialkylamino; or R15 and R3 together with the adjacent carbon atom form a 5- or 6-membered alkylene or alkylidene ring or a 5- or 6-membered alkylene or alkenylene ring wherein one or two carbon ring members are replaced by a nitrogen, sulfur or oxygen atom, and which ring is unsubstituted or carries one to three of the following radicals: halogen, nitro, cyano, hydroxyl, mercapto, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-alkylthio, amino, C1-C3-alkylamino and C1-C3-dialkylamino; R3 is one of the radicals given for R2, Y is nitrogen; R4 is phenyl which is unsubstituted or carries one or more of the following radicals halogen, nitro, cyano, hydroxyl, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, phenoxy, phenyl, C1-C4-alkylthio, amino, C1-C4-alkylamino and C1-C4-dialkylamino, or R4 and R5 are each phenyl groups which are connected to each other in the ortho positions by a direct linkage, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO2, NH or N-alkyl group; R5 is cyclohexyl, phenyl or naphthyl which is unsubstituted or carries from one to three of the following radicals: halogen, nitro, cyano, hydroxyl, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, phenoxy, phenyl, C1-C4-alkylthio, amino, C1-C4-alkylamino, C1-C4-dialkylamino and two radicals on adjacent carbon atoms which form an alkylene or alkylidene group, a ring having 5 or 6 ring members selected from methylene, methylidene and oxygen; R6 is hydrogen, C1-C4-alkyl or C1-C4-haloalkyl Z is a single bond, oxygen, sulfur, sulfinyl or sulfonyl; R7 is hydrogen or C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl; Q is a single bond, a â€ƒgroup R8 is hydrogen, C1-C4-alkyl, C2-C4-alkenyl, phenyl or benzyl, and R8 can furthermore be directly connected to R5 as described above, in which case R8 is a CHâ€”R17 group where R17 is hydrogen, C1-C4-alkyl, phenyl or phenyl which is mono- to trisubstituted by methoxy, or is one of the following radicals