Patent ID: 6388095
Filing Date: 2002-05-14
Classification: A61P,C07C,C07D

Abstract:
A compound of the following formula (I), or a solvate or pharmaceutically acceptable salt thereof: wherein Y and E are independently selected from â€”CH2â€”R16 or a group represented by the following formula (II): wherein R, R1, R2, R3, R4, R5, and R16 are independently selected from hydrogen, C1-C8 alkyl, C3-C8 alkoxyalkyl and C7-C12 aralkyl; m is an integer of from 1 to 8 and n is an integer of from 0 to 8; A is selected from C5-C12 alkyl, a C3-C13 carbocyclic ring, and ring systems selected from formulae (III), (IV), (V), (VI), (VII), (VIII), (IX) and (X): where R7, R8, R9 R10, R11 and R12 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C2-C7 alkanoyloxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C7 alkoxycarbonyl, C1-C6 thioalkyl, aryl and N(R13,R14) where R13 and R14 are independently selected from hydrogen, acetyl, methanesulfonyl and C1-C6 alkyl, and Z is selected from CH, CH2, O, N and S, where Z may be directly bonded to X when Z is CH, or X may be a direct bond to Z when Z is N, or Z may be directly bonded to R15 when Z is N and X is not a direct bond to Z, R15 is selected from hydrogen, C1-C6 alkyl, C3-C8 cyclocalkyl, aryl and benzyl; and X is Nâ€”R6 except when Z in A is nitrogen and X is a direct bond to Z; Anâˆ’ is the acid addition salt of a pharmaceutically acceptable acid or the anion from a pharmaceutically acceptable salt, and isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof, with the proviso that E is represented by formula (II) wherein A is either formula (VI) or formula (IX) and Z is N.