Patent ID: 6118009
Filing Date: 2000-09-12
Classification: C07D

Abstract:
A procedure for obtaining the enantiomers of cyzolirtine, (.+-.)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine, of formula I, ##STR4## that comprises the enantioselective reduction of the pro-chiral ketone of formula III ##STR5## using a borane reducing agent and a chiral catalyst derived from boron selected from a chiral oxazaborolidine, in an anhydrous solvent or mixture of anhydrous solvents at temperatures lying between -78.degree. C. and 55.degree. C., to form an enantiomer of the alcohol of formula II, ##STR6## and the alkylation, in phase transfer conditions, of this optically active compound, prior to isolation and purification or without isolation, with 2-chloro-N,N-dimethylethylamine.