Patent ID: 7858791
Filing Date: 2010-12-28
Classification: C07D

Abstract:
1. A process for preparing cabergoline (I) comprising the following steps: a) reacting the compound of formula (XIII) wherein R i) with a compound of formula (XIV), X—COOR wherein R X represents a bromine or chlorine atom, or (ii) with a compound of formula (XV), O(COOR b) reacting the obtained carbamate of formula (XVI) wherein R 1 and R 2 is a group as defined above, with 3-(dimethylamino)propylamine in the presence of a catalyst; c) reacting the obtained ergoline-8β-carboxamide of formula (XVII) wherein R 2 is a group as defined above, with ethyl isocyanate in the presence of ligand(s) and Ib and IIb metal group salt catalyst; d) reacting the obtained protected N-acylurea of formula (XVIII) wherein R 2 is a group as defined above, with a strong aqueous inorganic acid; and e) reacting the obtained secondary amine of formula (XIX) with an electrophilic allyl alcohol in the presence of a palladium or nickel containing catalyst and optionally in the presence of ligand(s) to form cabergoline (I).