Patent ID: 6136782
Filing Date: 2000-10-24
Classification: A61K,C07K

Abstract:
A multimeric antithrombotic agent comprising:(a) at least two copies of a platelet binding peptide comprising an amino acid sequence of between about 3 to about 100 amino acids; and(b) a polyvalent linking moiety which is covalently bonded to each peptide thereby linking said peptides, wherein said peptide has a formulaA-R.sup.1 -X-Gly-Asp-(aa).sub.n -Z-Bwherein A is selected from the group consisting of H, an amine protecting group and(aa).sub.p, where (aa).sub.p is a peptide comprising an amino acid sequence of length p, wherein when an amino acid (aa) is cysteine, said cysteine may be protected at a sidechain sulfur atom, and p is an integer from 0 to 97;R.sup.1 is selected from the group consisting of a lipophilic amino acid and H;X is an amino acid capable of being positively charged;(aa).sub.n is a peptide comprising an amino acid sequence of length n, wherein when an amino acid (aa) is cysteine, said cysteine may be protected at a sidechain sulfur atom; n is an integer from 0 to 97;Z is absent or selected from the group consisting of cysteine, isocysteine and homocysteine;B is selected from the group consisting of --OH, --NH.sub.2, --SH, and (aa).sub.m, wherein (aa).sub.m is a peptide comprising an amino acid sequence of length m, wherein when an amino acid (aa) is cysteine, said cysteine may be protected at a sidechain sulfur atom, and m is an integer from 0 to 97; andn+m+p is.ltoreq.97.