Patent ID: 6040321
Filing Date: 2000-03-21
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR647## and pharmaceutically acceptable salts thereof wherein: R.sub.1 and R.sub.2 are independently hydrogen, fluorine or alkyl;R.sub.3 is aryl or heteroaryl;R.sub.4 is alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl,heterocycloalkylalkyl; orCO-alkyl, CO-cycloalkyl, CO-aryl, CO-alkyl-cycloalkyl, CO-alkyl-aryl,CO-heteroaryl, CO-alkyl-heteroaryl, CO-heterocycloalkyl,CO-alkyl-heterocycloalkyl; orCONH-alkyl, CONH-cycloalkyl, CONH-aryl, CONH-alkyl-cycloalkyl, CONH-alkyl-aryl, CONH-heteroaryl,CONH-alkyl-heteroaryl, CONH-heterocycloalkyl,CONH-alkyl-heterocycloalkyl; orCOO-alkyl, COO-cycloalkyl, COO-aryl, COO-alkyl-cycloalkyl,COO-alkyl-aryl, COO-heteroaryl, COO-alkyl-heteroaryl,COO heterocycloalkyl, COO-alkyl-heterocycloalkyl; orSO.sub.2 -cycloalkyl, SO.sub.2 -aryl, SO.sub.2 -alkyl-cycloalkyl, SO.sub.2 -alkyl-aryl, SO.sub.2 -heteroaryl, SO.sub.2 -alkyl-heteroaryl, SO.sub.2 -heterocycloalkyl, SO.sub.2 -alkyl-heterocycloalkyl; or C(NCN)NH-alkyl, C(NCN)NH-cycloalkyl, C(NCN)NH-aryl,C(NCNNH)-alkyl-cycloalkyl, C(NCN)NH-alkyl-aryl,C(NCN)NH-heteroaryl, C(NCN)NH-alkyl-heteroaryl,C(NCN)NH-heterocycloalkyl, C(NCN)NH-alkyl-heterocylcoalkyl; orC(NNO.sub.2)NH-alkyl, C(NNO.sub.2)NH-cycloalkyl, C(NNO.sub.2)NH-aryl,C(NNO.sub.2)NH-alkyl-cycloalkyl, C(NNO.sub.2)NH-alkyl-aryl,C(NNO.sub.2)NH-heteroaryl, C(NNO.sub.2)NH-alkyl-heteroaryl,C(NNO.sub.2)NH-heterocyloalkyl, C(NNO.sub.2)NH-alkyl-heterocycloalkyl; orC(NH)NH-alkyl, C(NH)NH-cycloalkyl, C(NH)NH-aryl,C(NH)NH-alkyl-cycloalkyl, C(NH)NH-alkyl-aryl,C(NH)NH-heteroaryl, C(NH)NH-alkyl-heteroaryl,C(NH)NH-heterocycloalkyl, C(NH)NH-alkyl-heterocycloalkyl; orC(NH)NHCO-alkyl, C(NH)NHCO-cycloalkyl, C(NH)NHCO-aryl,C(NH)NHCO-alkyl-cycloalkyl, C(NH)NHCO-alkyl-aryl,C(NH)NHCO-heteroaryl, C(NH)NHCO-alkyl-heteroaryl,C(NH)NHCO-heterocylcloalkyl,C(NH)NHCO-alkyl-heterocycloalkyl; orC(NOR.sub.6)NH-alkyl, C(NOR.sub.6)NH-cycloalkyl, C(NOR.sub.6)NH-aryl,C(NOR.sub.6)NH-alkyl-cycloalkyl, C(NOR.sub.6)NH-alkyl-aryl,C(NOR.sub.6)NH-heteroaryl, C(NOR.sub.6)NH-alkyl-heteroaryl,C(NOR.sub.6)NH-heterocylcoalkyl, C(NOR.sub.6)NH-alkyl-heterocycloalkyl;R.sub.5 is hydrogen or alkyl;R.sub.6 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylakyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;m is an integer of 0 to 2; andn is an integer of 1 to 3.