Patent ID: 6310005
Filing Date: 2001-10-30
Classification: A01N,C07D

Abstract:
An isothiazolecarboxamide of the formula ##STR55##whereinR represents a radical of the formula--A.sup.1 --R.sup.5,whereinA.sup.1 represents --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or ##STR56##andR.sup.5 represents thiazolidinethion-3-yl, morpholinyl, piperazinyl, pyrazolyl, imidazolyl, 1,2,4-triazolyl, pyrrolyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, triazinyl, 1,2,3-triazolyl, benzotriazolyl, quinolinyl, isoquinolinyl, quinazolinyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl or benzimidazolyl, where these radicals may be unsubstituted or mono- or disubstituted by identical or different substituents from the group consisting of fluorine, chlorine, bromine, cyano, nitro, carboxyl, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, halogenoalkyl having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, propoxy, isopropoxy, tert-butoxy, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylthio, ethylthio, halogenoalkylthio having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylamino, ethylamino, dimethylamino, diethylamino, phenyl and phenoxy, orR represents a radical of the formula ##STR57##whereinR.sup.1 represents hydrogen or alkyl having 1 to 4 carbon atoms,R.sup.2 represents alkoxy having 1 to 4 carbon atoms or represents morpholinyl, piperazinyl, pyrazolyl, imidazolyl, 1,2,4-triazolyl, pyrrolyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, triazinyl or 1,2,3-triazolyl, where these radicals may be unsubstituted or mono- or disubstituted by identical or different substituents from the group consisting of fluorine, chlorine, bromine, cyano, nitro, carboxyl, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, halogenoalkyl having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, propoxy, isopropoxy, tert-butoxy, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylthio, ethylthio, halogenoalkylthio having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylamino, ethylamino, dimethylamino, diethylamino, phenyl and phenoxy, andm represents 1 or 2, orR represents a radical of the formula ##STR58##whereinR.sup.3 represents a heterocycle of the formula ##STR59##or represents morpholinyl, piperazinyl, pyrazolyl, imidazolyl, 1,2,4-triazolyl, pyrrolyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, triazinyl or 1,2,3-triazolyl, where these radicals may be unsubstituted or mono- or disubstituted by identical or different substituents from the group consisting of fluorine, chlorine, bromine, cyano, nitro, carboxyl, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, halogenoalkyl having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, propoxy, isopropoxy, tert-butoxy, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylthio, ethylthio, halogenoalkylthio having 1 or 2 carbon atoms and 1 to 3 fluorine, chlorine and/or bromine atoms, methylamino, ethylamino, dimethylamino, diethylamino, phenyl and phenoxy orR.sup.3 represents a radical of the formula ##STR60##whereinR.sup.4 represents cyclopropyl, cyclopentyl or cyclohexyl, andn represents 1 or 2, orR represents morpholinyl, piperazinyl, pyrazolyl, imidazolyl, 1,2,4-triazolyl, pyrrolyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, triazinyl, 1,2,3-triazolyl, benzotriazolyl, quinolinyl, isoquinolinyl, quinazolinyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl or benzimidazolyl, where these radicals may be unsubstituted or mono- or disubstituted by identical or different substituents from the group consisting of fluorine, chlorine, bromine, cyano, nitro, carboxyl, methyl, ethyl, trifluoromethyl, difluoromethyl, trichloromethyl, methoxycarbonyl, ethoxycarbonyl, methoxy, ethoxy, trifluoromethoxy, methylthio, trifluoromethylthio, methylamino, dimethylamino, phenyl and phenoxy.