Patent ID: 7972592
Filing Date: 2011-07-05
Classification: A61K,C12N,Y02A

Abstract:
1. A method for reducing risk of contracting Type 1 Diabetes mellitus (IDDM) comprising the steps of selecting from a population as a whole a child from a high risk group consisting of children with genetic risk alleles for Type I Diabetes Mellitus (IDDM), children having first degree relatives with diabetes, and children tested positive for diabetes-related autoantibodies, and administering an inactivated or subunit, diabetogenic non-polio enterovirus vaccine that induces neutralizing antibodies to at least one diabetogenic non-polio enterovirus to reduce his or her risk of contracting IDDM, wherein the at least one diabetogenic non-polio enterovirus is selected from the group consisting of coxsackievirus B serotypes 1, 2, 3, 4, 5 and 6, echovirus serotypes 3, 4, 6, 9, 11, 22 and 30, and coxsackievirus A serotypes 9 and 16.