Patent ID: 6242468
Filing Date: 2001-06-05
Classification: A61K,A61P

Abstract:
A method of effecting a neuronal activity in an animal, comprising:administering to the animal an effective non-immunosuppressive amount of a compound of formula I: ##STR17##or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:A is CH.sub.2, O, or NR;R, B and D are independently Ar, hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl, C.sub.5 -C.sub.7 cycloalkyl substituted C.sub.1 -C.sub.9 straight or branched chain alkyl or C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl, C.sub.5 -C.sub.7 cycloalkenyl substituted C.sub.1 -C.sub.9 straight or branched chain alkyl or C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl, Ar substituted C.sub.1 -C.sub.9 straight or branched chain alkyl, or Ar substituted C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl; wherein any carbon atom of said alkyl is optionally replaced by a heteroatom selected from the group consisting of O, S, SO, SO.sub.2 and NR.sub.3 ;R.sub.3 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl, and C.sub.1 -C.sub.9 bridging alkyl wherein a bridge is formed between the nitrogen and a carbon atom of said heteroatom-containing chain to form a ring, and wherein said ring is optionally fused to an Ar group;J is selected from the group consisting of hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl, and --CH.sub.2 Ar; K is selected from the group consisting of C.sub.1 -C.sub.9 straight or branched chain alkyl, --CH.sub.2 Ar, and cyclohexylmethyl; or J and K are taken together to form a 5-7 membered heterocyclic ring which is substituted with O, S, SO, or SO.sub.2 ;Z is O or S;Y is O or N, provided thatwhen Y is O, then R.sub.1 is a lone pair of electrons and R.sub.2 is selected from the group consisting of Ar, C.sub.1 -C.sub.9 straight or branched chain alkyl, and C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl; andwhen Y is N, then R.sub.1 and R.sub.2 are independently selected from the group consisting of Ar, hydrogen, C.sub.1 -C.sub.9 straight or branched chain alkyl, C.sub.2 -C.sub.9 straight or branched chain alkenyl or alkynyl, C.sub.3 -C.sub.7 cycloalkyl, cycloalkenyl or cycloalkynyl, C.sub.6 -C.sub.14 bicycloalkyl, bicycloalkenyl or bicycloalkynyl, and C.sub.9 -C.sub.21 tricycloalkyl, tricycloalkenyl or tricycloalkynyl; or R.sub.1 and R.sub.2 are taken together to form a heterocyclic 5-6 membered ring selected from the group consisting of pyrrolidine, imidazolidine, pyrazolidine, piperidine, and piperazine;Ar is a carbocyclic or heterocyclic aromatic moiety which is unsubstituted or substituted with one or more substituent s);q is 0-2; andn is 0 or 1.