Patent ID: 6495370
Filing Date: 2002-12-17
Classification: C07D,Y10S,Y10T

Abstract:
A method for detecting a glutathione-S-transferase isoenzyme in a biological specimen comprising the measurement of glutathione-S-transferase enzymatic activity in the presence and absence an amount of a compound of the formula: in which:Ar is an aryl group; R1 and R2: a) together form a double bond between carbon atoms 1 and 2; b) together form an epoxy group between carbon atoms 1 and 2: or c) are the same or different and are independently selected from the group consisting of H, OH, glutathione thioether, glutathione-S-oxide thioether, and glutathione-S,S-dioxide thioether; R3 is selected from the group consisting of H, OH, glutathione thioether, glutathione-S-oxide thioether, and glutathione-S,S-dioxide thioether; and Y is a haloenol lactone, wherein said amount is effective to selectively inhibit said glutathione-S-transferase isoenzyme.