Patent ID: 6515104
Filing Date: 2003-02-04
Classification: A61K,C07K

Abstract:
A peptide-based construct of 8-14 amino acid moieties in length having heparin binding, heparin neutralizing, endothelial cell proliferation inhibiting, or antiangiogenic properties comprising:a sequence having the formula: &agr;-&khgr;-&khgr;-&agr;-&khgr;-&bgr;-&khgr;-&agr;-R â€ƒwherein, &agr; is a hydrophilic basic amino acid moiety selected from the group consisting of lysine, arginine, histidine, ornithine, diaminobutyric acid, citrulline, and para-amino phenylalanine; &bgr; is a hydrophilic neutral amino acid moiety selected from the group consisting of asparagine, glutamine, serine, threonine, tyrosine, hydroxyproline, and 7-hydroxy-tetrahydroisoquinoline carboxylic acid; &khgr; is a hydrophobic amino acid moiety selected from the group consisting of alanine, naphthylalanine, biphenylalanine, valine, leucine, isoleucine, proline, hydroxyproline, phenylalanine, tryptophan, methionine, glycine, cyclohexylalanine, amino-isobutyric acid, norvaline, norleucine, tert-leucine, tetrahydroisoquinoline carboxylic acid, pipecolic acid, phenylglycine, homophenylalanine, cyclohexylglycine, dehydroleucine, 2, 2-diethylglycine, 1-amino-1-cyclopentane carboxylic acid, 1-amino-1-cyclohexane carboxylic acid, amino-benzoic acid, amino-naphthyl carboxylic acid, &ggr;-amino butyric acid, beta-alanine, difluorophenylalanine, fluorophenylalanine, nipecotic acid, aminobutyric acid, thienyl-alanine, and t-butyl-glycine; and R is an amino acid moiety selected from the group consisting of -&khgr;, -&khgr;-&agr;, -&khgr;-&agr;-&khgr;, &khgr;-&agr;-&khgr;-&bgr;, -&khgr;-&agr;-&khgr;-&bgr;-&khgr;, -&khgr;-&agr;-&khgr;-&bgr;-&khgr;-&agr;, -&khgr;-&bgr;-&khgr;-&khgr;-&bgr;-&khgr;, -NH2, -&khgr;-NH2, -&khgr;-&agr;-NH2, -&khgr;-&agr;-&khgr;-NH2, -&khgr;-&agr;-&khgr;-&bgr;-NH2, -&khgr;-&agr;-&khgr;-&bgr;-&khgr;-NH2, -&khgr;-&agr;-&khgr;-&bgr;-&khgr;-&agr;-NH2, and -&khgr;-&bgr;-&khgr;-&khgr;-&bgr;-&khgr;-NH2.