Patent ID: 7960606
Filing Date: 2011-06-14
Classification: A01K,A61K,C07K,C12N

Abstract:
1. A transgenic mouse whose genome comprises: (a) a homozygous disruption of the endogenous Scavenger Receptor class B, type I gene (SR-B1 (b) a homozygous Arg-61 allelic variant of mouse apolipoprotein E gene (ApoE (c) an inducible Mx1-Cre transgene, wherein feeding the mouse a cholesterol enriched diet results in the induction of myocardial infarction and wherein following said myocardial infarction, normal ApoE levels can be restored by spatially and temporally regulating expression of the ApoE gene by inducing the Mx1-Cre gene and allowing the transgenic mouse to rapidly reduce its blood cholesterol and live with chronic heart failure while displaying myocardial infarctions and enlarged ventricles.