Patent ID: 6716587
Filing Date: 2004-04-06
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
A method of inhibiting binding of interleukin-4 (IL-4) to an IL-4 Receptor (IL-4R), said method comprising contacting an IL-4R with an antibody to IL-4R, wherein said antibody inhibits binding of IL-4 to the IL-4R,wherein the antibody is reactive with an IL-4R selected from the group consisting of: a) a human IL-4R comprising amino acids 1 to 800 of FIGS. 4A-4C; b) a soluble human IL-4R comprising amino acids 1 to 207 of FIG. 4A; c) a murine IL-4R comprising amino acids 1 to 785 of FIGS. 2A-2C; and d) a soluble murine IL-4R comprising amino acids 1 to 208 of FIG. 2A.