Patent ID: 7816304
Filing Date: 2010-10-19
Classification: C07H,C07K,C12Q,C40B,G01N,Y10T

Abstract:
1. A method of analysis, which method comprises detecting an analyte by identifying by mass spectrometry a mass label or a combination of mass labels relatable to the analyte, wherein the mass label is selected from: (a) a mass label from a set of two or more mass labels, each mass label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalisation moiety, the mass marker moiety being fragmentation resistant, wherein each mass normalisation moiety ensures that each mass label in the set has the same aggregate mass as determined by mass spectrometry, and wherein each mass marker moiety has a mass different from that of all other mass marker moieties as determined by mass spectrometry, and wherein all the mass labels in the set are distinguishable from each other by mass spectrometry; or (b) a mass label from an array comprising two or more sets of mass labels as defined in (a), wherein the aggregate mass of each of the mass labels of any one set in the array is different from the aggregate mass of each of the mass labels of every other set in the array.