Patent ID: 8052965
Filing Date: 2011-11-08
Classification: A61K,C07K,C12N

Abstract:
1. A replication competent recombinant adenovirus, being capable to replicate and having lytic capacity in target cells, wherein said target cells are hampered in a p53 dependent apoptosis pathway, wherein the adenovirus is a conditionally replicating adenovirus; wherein the adenovirus genome comprises a coding sequence of at least one mammalian restoring factor functional in restoring the p53 apoptosis pathway in said target cells; wherein said coding sequence is operably linked to one or more expression control sequences functional in said target cells, whereby said restoring factor induces accelerated cell lysis and/or a faster release of virus progeny when compared to the recombinant adenovirus lacking said coding sequence, and wherein the virus genome further comprises a gene selected from a gene encoding the adenovirus E1B-19 kDa protein or a functional analog or derivative thereof and a gene encoding the adenovirus E1B-55 kDa protein or a functional analog or derivative thereof.