Patent ID: 7091214
Filing Date: 2006-08-15
Classification: A61P,C07D

Abstract:
1. A compound of formula (II): wherein: R is selected from the group consisting of alkyl, alkoxy, hydroxy, and trifluoromethyl; n is 0 or 1; R R R Ar is selected from the group consisting of aryl and heteroaryl both of which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, methylenedioxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, aryl, aryloxy, arylalkoxy, heteroaryl, heteroaryloxy, heteroarylalkoxy, heterocyclyl, heterocyclylalkyl, amino, alkylamino, and dialkylamino; Ar′ is selected from the group consisting of arylene and heteroarylene both of which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, aryl, aryloxy, arylalkoxy, heteroaryl, heteroaryloxy, heteroarylalkoxy, heterocyclyl, heterocyclylalkyl, amino, alkylamino, and dialkylamino; each X is independently selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, heteroarylene, and heterocyclylene wherein the alkylene, alkenylene, and alkynylene groups can be optionally interrupted or terminated with arylene, heteroarylene, or heterocyclylene, and optionally interrupted by one or more —O— groups; each Y is independently selected from the group consisting of: Z is selected from the group consisting of a bond, alkylene, alkenylene, and alkynylene; each R each R each R each R R R each R A is selected from the group consisting of —O—, —C(O)—, —S(O) Q is selected from the group consisting of a bond, —C(R V is selected from the group consisting of —C(R W is selected from the group consisting of a bond, —C(O)—, and —S(O) a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7; and wherein heteroaryl is selected from the group consisting of furyl, thienyl, pyridyl, quinolinyl, isoquinolinyl, indolyl, isoindolyl, trialkyl, pyrrolyl, tetrazolyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, benzofuranyl, benzothiophenyl, carbazolyl, benzoxazolyl, pyrimidinyl, benzimidazolyl, quinoxalinyl, benzothiazolyl, naphthyridinyl, isoxazolyl, isothiazolyl, purinyl, quinazolinyl, pyrazinyl, 1-oxidopyridyl, pyridazinyl, triazinyl, tetrazinyl, oxadiazoyl, and thiadiazolyl; and heterocyclyl is selected from the group consisting of the fully saturated and partially unsaturated derivatives of the above heteroaryl groups and from the group consisting of pyrrolidinyl, tetrahydrofuranyl, morpholinyl, thiomorpholinyl, piperidinyl, piperazinyl, thiazolidinyl, imidazolidinyl, isothiazolidinyl, tetrahydropyranyl, quinuclidinyl, homopiperidinyl, and homopiperazinyl; or a pharmaceutically acceptable salt thereof.