Patent ID: 6919344
Filing Date: 2005-07-19
Classification: A61P,C07D

Abstract:
1. A method of treating asthma and/or allergic reaction in a mammal comprising the step of administering to said mammal a treatment-effective amount of an N-substituted indol-3-glyoxylamide of formula I: or an acid addition salt thereof; wherein the radicals R, R 1 , R 2 , R 3 , R4 and Z have the following meanings: R represents (1) hydrogen, or (2) (C which ring is optionally mono- or polysubstituted by halogen, (C R (1) a phenyl ring which is mono- or polysubstituted by (C (2) a 2- or 4-pyrimidinyl-heterocycle or a pyridylmethyl radical in which CH (3) a 2-, 3- or 4-quinolyl structure substituted by (C (4) a 2-, 3- or 4-quinolyl methyl group wherein the ring carbons of the pyridylmethyl and quinolylmethyl radicals are optionally substituted by (C (5) if R represents hydrogen or a benzyl group, R (6) an allylaminocarbonyl-2-methylprop-1-yl group; or R or a homopiperazine ring if R 1 represents an aminoalkylene group, in which R 7 represents an alkyl radical, a phenyl ring which is optionally mono- or polysubstituted by (C 1 -C 6 -alkyl, (C 1 -C 6 )-alkoxy, halogen, a intro group, an amino function, (C 1 -C 6 )-alkylamino, benzhydryl group or bis-p-fluorobenzylhydryl group; R (1) hydrogen; (2) a (C (3) an aroyl radical, wherein the aroyl moiety on which the radical is based is a phenyl ring which is optionally mono- or polysubstituted by halogen, (C R Z represents O; wherein alkyl, alkanol, alkoxy and alkylamino groups may be straight chained or branched.