Patent ID: 8304241
Filing Date: 2012-11-06
Classification: B01D,B01J,Y10T

Abstract:
1. A method for generating a predicted positive crystallization condition for a crystallant of interest, the method comprising the steps of: (a) conducting an initial crystallization screen on the crystallant of interest, the initial crystallization screen comprising a plurality of crystallization conditions, each of the crystallization conditions having one or more crystallization condition variables; (b) determining a crystallization outcome for at least one of the crystallization conditions of the initial crystallization screen; (c) determining for at least one of the crystallization conditions of the initial crystallization screen a dilute solution thermodynamic virial coefficient (B) parameter; (d) inputting a data set into a predictive crystallization function, the data set including information selected from the group consisting of: (i) one or more of the crystallization condition variables for at least one of the crystallization condition of the initial crystallization screen, (ii) the crystallization outcome for at least one of the crystallization condition of the initial crystallization screen, (iii) the B parameter for at least one of the crystallization condition of the initial crystallization screen, and (iv) any combination of the foregoing; (e) training the predictive crystallization function using the data set where the training is continued until the predictive crystallization function reaches a suitable convergence; and (f) generating the predicted positive crystallization condition for the crystallant of interest using the converged values of crystallization variables in the predictive crystallization function.