Patent ID: 6433007
Filing Date: 2002-08-13
Classification: A61K,A61P,Y10S

Abstract:
A method for the treatment, prevention or amelioration of post-surgical formation of posterior subcapsular cataract or posterior capsule opacification which comprises administering to a mammal prior to, during or following surgery, or combinations thereof, one or more composition(s) comprising a pharmaceutically acceptable vehicle and a therapeutically effective amount of a compound of formula (I):Aâ€”Xâ€”(CH2)nâ€”Yâ€”(CH2)mâ€”Zâ€ƒâ€ƒ(I) wherein:A is an non-steroidal anti-inflammatory agent (NSAIA) originally having a carboxylic acid; Aâ€”X is an ester or amide linkage derived from the carboxylic acid moiety of the NSAIA, wherein X is O or NR; R is H, C1-C6 alkyl or C3-C6 cycloalkyl; Y, if present, is O, NR, C(R)2, CH(OH) or S(O)nâ€²; n is 2 to 4 and m is 1 to 4 when Y is O, NR, or S(O)nâ€²; n is 0 to 4 and m is 0 to 4 when Y is C(R)2 or is not present; n is 1 to 4 and m is 0 to 4 when Y is CH(OH); nâ€² is 0 to 2; and Z is: wherein:A is â€ƒwherein: Râ€² is H, C(O)R, C(O)N(R)2, PO3âˆ’, or SO3âˆ’; and Râ€³ is H or C1-C6 alkyl; and pharmaceutically acceptable salts therefor.