Patent ID: 8795976
Filing Date: 2014-08-05
Classification: A61P,C12N,C12Q

Abstract:
1. A method of screening for a compound for treating breast cancer, said method comprising the steps of: (a) contacting a test compound with a polypeptide selected from the group consisting of: (1) a polypeptide comprising the amino acid sequence of SEQ ID NO: 27; (2) a polypeptide encoded by the nucleotide sequence of SEQ ID NO: 26 which is expressed endogenously or exogenously by cells; (b) detecting a biological activity of the polypeptide of step (a), wherein the biological activity is acetylgalactosaminyltransferase; and (c) identifying a compound that suppresses the biological activity of the polypeptide in comparison with the biological activity detected in the absence of the test compound; (d) culturing animal cells which express the polypeptide defined in (a) (1) in the presence of the test compound identified in step (c); (e) detecting the promotion of proliferation of the animal cells; and (f) identifying a compound that suppresses the promotion of proliferation of the animal cells in comparison with that detected in the absence of the test compound, as a candidate compound to be used for the treatment of breast cancer.