Patent ID: 8986699
Filing Date: 2015-03-24
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a disease associated with CD74 expressing cells comprising a) administering to an individual with the disease an immunoconjugate comprising at least one anti-CD74 antibody or antigen-binding antibody fragment; and b) killing the CD74 expressing cells, wherein the anti-CD74 antibody is an LL1 antibody comprising the light chain variable region complementarity-determining region (CDR) sequences CDR1 (RSSQSLVHRNGNTYLH; SEQ ID NO:1), CDR2 (TVSNRFS; SEQ ID NO:2), and CDR3 (SQSSHVPPT; SEQ ID NO:3) and the heavy chain variable region CDR sequences CDR1 (NYGVN; SEQ ID NO:4), CDR2 (WINPNTGEPTFDDDFKG; SEQ ID NO:5), and CDR3 (SRGKNEAWFAY; SEQ ID NO:6).