Patent ID: 6947846
Filing Date: 2005-09-20
Classification: G06F,G16B

Abstract:
1. A method for predicting gene relationships comprising: providing a control sample and a plurality of experimental samples; performing one experiment on each of the plurality of experimental samples; measuring a first gene control signal corresponding to a first gene from the control sample; measuring a first gene experimental signal corresponding to the first gene from each of the plurality of experimental samples; calculating a first expression ratio corresponding to the first gene for each of the plurality of experimental samples; discretizing the first expression ratio for each of the plurality of experimental samples into one of three indications, where the three indications representing the first gene up-regulated, not changed, or down-regulated; measuring a second gene control signal corresponding to a second gene from the control samples; measuring a second gene experimental signal corresponding to the second gene from each of the plurality of experimental samples; calculating a second expression ratio corresponding to the second gene for each of the plurality of experimental samples; discretizing the second expression ratio for each of the plurality of experimental samples into one of the three indications, where the three indications representing the second gene up-regulated, not changed, or down-regulated; calculating the probability that the combination of the discretized first expression ratio for each of the plurality of experimental samples and the discretized second expression ratio for each of the plurality of experimental samples arises by random chance; and determining whether the first gene and the second gene are related.