Patent ID: 8454678
Filing Date: 2013-06-04
Classification: A61F,A61L

Abstract:
1. A prosthetic valve device for implantation in a bodily passage, comprising: an artificial valve comprising a frame and at least two leaflets attached thereto, wherein said leaflets include a first leaflet and a second leaflet formed with an extracellular matrix composite material including a first extracellular matrix material having a surface, and a second, biosynthetically-deposited extracellular matrix material including extracellular matrix proteins on said surface, said biosynthetically-deposited extracellular matrix material having been deposited on said first extracellular matrix material by cells cultured on said first extracellular matrix material followed by removal of said cells to provide said extracellular matrix composite material; wherein said extracellular matrix proteins enhance the function of said first extracellular matrix material in each said leaflet by modifying the thrombogenicity and remodeling of the first extracellular matrix material; wherein said artificial valve has a length of coaptation in the range of about 5 to 30 mm; wherein said first leaflet and said second leaflet each include a first outer edge; wherein the first outer leaflet edges of the first and second leaflets are within about 3 mm of one another as they extend in a longitudinal direction along said frame for a distance of about 5 to about 30 mm; and wherein the valve device is configured such that at least a portion of said outer leaflet edges extending in a longitudinal direction contact the bodily passage when the valve device is implanted in the bodily passage.