Patent ID: 6821960
Filing Date: 2004-11-23
Classification: C07C,C07D

Abstract:
A compound of the general formula (I): whereinR2 is hydrogen or C1-6-alkyl, Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromatic ring containing 1 or 2 heteroatoms selected from nitrogen, oxygen and sulfur, which may optionally be substituted with one or two groups R7 and R8 selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR9, â€”NR9R10 and C1-6-alkyl, wherein R9 and R10 independently are hydrogen or C1-6-alkyl, X is whereinr is 0 or 1, q and s independently are 0, 1, 2 or 3, R11, R12, R13 and R14 independently are hydrogen or C1-6-alkyl, D is whereinR15, R16, R17 and R18 independently are hydrogen, halogen, â€”CN, â€”CH2CN, â€”CHF2, â€”CF3, â€”OCF3, â€”OCHF2, â€”OCH2CF3, â€”OCF2CHF2, â€”S(O)2CF3, â€”SCF3, â€”NO2, â€”OR21, â€”NR21R22, â€”SR21, â€”NR21S(O)2R22, â€”S(O)2NR21R22, â€”S(O)NR21R22, â€”S(O)R21, â€”S(O)2R21, â€”C(O)NR21R22, â€”OC(O)NR21R22, â€”NR21C(O)R22, â€”CH2C(O)NR21R22, â€”OCH2C(O)NR21R22, â€”CH2OR21, â€”CH2NR21R22, â€”OC(O)R21, â€”C(O)R21 or â€”C(O)OR21, C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, which may optionally be substituted with one or more substituents selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR21, â€”NR21R22 and C1-6-alkyl, C3-8-cycloalkyl, C4-8-cycloalkenyl, heterocyclyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C1-6-alkoxy, C3-8-cycloalkyloxy, C3-8-cycloalkyl-C1-6-alkylthio, C3-8-cycloalkylthio, C3-8-cycloalkyl-C2-6-alkenyl, C3-8-cycloalkyl-C2-6-alkynyl, C4-8-cycloalkenyl-C1-6-alkyl, C4-8-cycloalkenyl-C2-6-alkenyl, C4-8-cycloalkenyl-C2-6-alkynyl, heterocyclyl-C1-6-alkyl, heterocyclyl-C2-6-alkenyl, heterocyclyl-C2-6-alkynyl, aryl, aryloxy, aryloxycarbonyl, aroyl, aryl-C1-6-alkoxy, aryl-C1-6-alkyl, aryl-C2-6-alkenyl, aryl-C2-6-alkynyl, heteroaryl, heteroaryl-C1-6-alkyl, heteroaryl-C2-6-alkenyl or heteroaryl-C2-6alkynyl, of which the cyclic moieties optionally may be substituted with one or more substituents selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR21, â€”NR21R22 and C1-6-alkyl, wherein R21 and R22 independently are hydrogen, C1-6-alkyl or aryl, or R21 and R22 when attached to the same nitrogen atom together with the said nitrogen atom may form a 3 to 8 membered heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulfur, and optionally containing one or two double bonds, or two of the groups R15 to R18 when placed in adjacent positions together may form a bridge â€”(CR23R24)aâ€”Oâ€”(CR25R26)câ€”Oâ€”, wherein a is 0, 1 or 2, c is 1 or 2, R23, R24, R25 and R26 independently are hydrogen, C1-6-alkyl or fluorine, R19 and R20 independently are hydrogen, C1-6-alkyl, C3-8cycloalkyl or C3-8cycloalkyl-C1-6-alkyl, E is whereinR27 and R28 independently are hydrogen, halogen, â€”CN, â€”CF3, â€”OCF3, â€”OR32, â€”NR32R33, C1-6-alkyl, C3-8-cycloalkyl, C4-8-cycloalkenyl or aryl, wherein the cyclic moieties optionally may be substituted with one or more substituents selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR32, â€”NR32R33 and C1-6-alkyl, wherein R32 and R33 independently are hydrogen or C1-6-alkyl, or R32 and R33 when attached to the same nitrogen atom together with the said nitrogen atom may form a 3 to 8 membered heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulfur, and optionally containing one or two double bonds, R29, R30 and R31 independently are hydrogen, halogen, â€”CHF2, â€”CF3, â€”OCF3, â€”OCHF2, â€”OCH2CF3, â€”OCF2CHF2, â€”SCF3, â€”OR34, â€”NR34R35, â€”SR34, â€”S(O)R34, â€”S(O)2R34, â€”C(O)NR34R35, â€”OC(O)NR34R35, â€”NR34C(O)R35, â€”OCH2C(O)NR34R35, â€”C(O)R34 or â€”C(O)OR34, C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, which may optionally be substituted with one or more substituents selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR34, â€”NR34R35 and C1-6-alkyl, C3-8-cycloalkyl, C4-8-cycloalkenyl, heterocyclyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkyl-C2-6-alkenyl, C3-8-cycloalkyl-C2-6-alkynyl, C4-8-cycloalkenyl-C1-6-alkyl, C4-8-cycloalkenyl-C2-6-alkenyl, C4-8-cycloalkenyl-C2-6-alkynyl, heterocyclyl-C1-6-alkyl, heterocyclyl-C2-6-alkenyl, heterocyclyl-C2-6-alkynyl, aryl, aryloxy, aroyl, aryl-C1-6-alkoxy, aryl-C1-6-alkyl, aryl-C2-6-alkenyl, aryl-C2-6-alkynyl, heteroaryl, heteroaryl-C1-6-alkyl, heteroaryl-C2-6-alkenyl or heteroaryl-C2-6-alkynyl, of which the cyclic moieties optionally may be substituted with one or more substituents selected from halogen, â€”CN, â€”CF3, â€”OCF3, â€”NO2, â€”OR34, â€”NR34R35 and C1-6-alkyl, wherein R34 and R35 independently are hydrogen, C1-6-alkyl or aryl, or R34 and R35 when attached to the same nitrogen atom together with the said nitrogen atom may form a 3 to 8 membered heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulfur, and optionally containing one or two double bonds, or two of the groups R29, R30 and R31 when attached to the same ring carbon atom or different ring carbon atoms together may form a radical â€”Oâ€”(CH2)tâ€”CR36R37â€”(CH2)lâ€”Oâ€”, â€”(CH2)tâ€”CR36R37â€”(CH2)lâ€” or â€”Sâ€”(CH2)tâ€”CR36R37â€”(CH2)lâ€”Sâ€”, wherein t and l independently are 0, 1, 2, 3, 4 or 5, R36 and R37 independently are hydrogen or C1-6-alkyl, as well as any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.