Patent ID: 9102739
Filing Date: 2015-08-11
Classification: A61K,A61P,C07K

Abstract:
1. An anti-glypican-3 antibody comprising an Fc region having aspartic acid at EU numbering position 239, threonine at EU numbering position 326, alanine at EU numbering position 330, and glutamic acid at EU numbering position 332 of the Fc region, wherein the anti-glypican-3 antibody comprises a H-chain CDR1 as set forth in SEQ ID NO:23, a H-chain CDR2 as set forth in SEQ ID NO:24, and a H-chain CDR3 as set forth in SEQ ID NO:25, and comprises a L-chain CDR1 as set forth in SEQ ID NO:26, a L-chain CDR2 as set forth in SEQ ID NO:27, and a L-chain CDR3 as set forth in SEQ ID NO:28.