Patent ID: 6855706
Filing Date: 2005-02-15
Classification: A61P,C07C,C07D

Abstract:
1. A phenylalanine compound of the following general formula (1) or a pharmaceutically acceptable salt thereof: wherein X is —O—, Y is —C(═O)—, Z is —C(═O)—, A represents a group of general formula (2), a group of any of general formulae (2-1) to (2-5), a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with a group of general formula (2), a lower alkyl group substituted with an aryl group(s) or a lower alkyl group substituted with a heteroaryl group(s): wherein R wherein Arm represents benzene ring or an aromatic ring containing 1, 2, 3 or 4 hetero atoms selected from among oxygen, sulfur and nitrogen atoms, R R R R R R R B represents a hydroxyl group or a lower alkoxyl group, C represents a hydrogen atom or a lower alkyl group, D and E may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkenyl group substituted with an aryl group(s), a lower alkenyl group substituted with a heteroaryl group(s), a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a hydroxy-lower alkyl group, a lower alkylthio-lower alkyl group, a mercapto-lower alkyl group or a substituted or unsubstituted amino-lower alkyl group, or D and E may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, K represents OR J and J′ may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkyloxy group or nitro group.