Patent ID: 7982017
Filing Date: 2011-07-19
Classification: A61P,C07K

Abstract:
1. An isolated antibody that specifically binds to an epitope on a CD43 or a carcinoembryonic antigen (CEA) expressed by a nonhematopoietic cancer cell, said antibody comprising a heavy chain and a light chain, wherein (a) the heavy chain comprises a heavy chain variable region comprising the three complementary determining regions (CDRs) from the amino acid sequence of SEQ ID NO:1, and a heavy chain constant region comprising the amino acid sequence of SEQ ID NO:9, wherein the hinge region of the heavy chain constant region comprises at least one amino acid insertion, deletion or substitution; and (b) the light chain comprises a light chain variable region comprising the three complementary determining regions (CDRs) from the amino acid sequence of SEQ ID NO:2, and a light chain constant region comprising the amino acid sequence of SEQ ID NO:10 and further comprising at least one amino acid insertion in the constant region.