Patent ID: 8900627
Filing Date: 2014-12-02
Classification: A61K,A61P

Abstract:
1. A composition for the in vivo delivery of an RNAi agent, comprising an emulsion of a lipid component, an aqueous component, and a non-ionic surfactant, wherein the lipid component comprises 20-40% by weight of a neutral phospholipid and 60-80% by weight of an oil or wax, and wherein the percentage by weight of neutral phospholipid and the percentage by weight of oil or wax totals 100% of the lipid component; the aqueous component comprises an RNAi agent in an aqueous medium, wherein the RNAi agent is less than 200 nucleotides in length; and the surfactant comprises 0.1-50% of the total emulsion by weight; wherein the composition does not comprise a cationic lipid.