Patent ID: 6156551
Filing Date: 2000-12-05
Classification: A61K,C12N,C12Y

Abstract:
An activated SHP-2 protein tyrosine phosphatase mutant having a mutation in the SH2 domain, wherein the mutation is a substitution of an amino acid at position 4, 8, 9, 58, 59, 61, 62, 63, 69, 70, 71, 72, 74, 75, 76, and/or 77 of SEQ ID NO: 6, wherein an alanine residue substitutes the amino acid at positions 4, 8, 9, 58, 59, 61, 62, 63, 69, 70, 71, 72, 74, 75, 76 and/or 77.