Patent ID: 6413541
Filing Date: 2002-07-02
Classification: A61K

Abstract:
A method for producing an intrabuccally disintegrating tablet, which comprises the following Steps (a), (b) and (c), wherein a medicament is mixed at any stage of steps (a) or (b) before tabletting:(a) a step of dissolving at least one saccharide having a high solubility of about 40 g to about 250 g in 100 ml of purified water at about 25Â° C. and being selected from the group consisting of a monosaccharide, a sugar alcohol and a disaccharide and at least one water-soluble binder which is at least one member selected from the group consisting of polyvinylpyrrolidone, pullulan, hydroxypropylcellulose, hydroxypropylmethylcellulose, and water-soluble gelatin, in water alone or in water and an alcohol; (b) a step of mixing the solution obtained in the above Step (a) with at least one excipient, granulating, drying, and tabletting the mixture under a low compression pressure; (c) a step of aging the tablets obtained in the above Step (b).