Patent ID: 6211179
Filing Date: 2001-04-03
Classification: A61P,C07D

Abstract:
A method for treating a sexual dysfunction in an individual in need thereof comprising administering a therapeutically effective amount of a phosphodiesterase inhibitor and a compound that donates, transfers or releases nitrogen monoxide, induces the production of endogenous endothelium-derived relaxing factor, stimulates endogenous synthesis of nitrogen monoxide or is a substrate for nitric oxide synthase,wherein the phosphodiesterase inhibitor is a compound of structure III: ##STR21##wherein:E is nitrogen or --CH--;M is nitrogen or --C(R.sub.8)--;R.sub.8 is hydrogen or a lower alkyl;R.sub.21 is: ##STR22##R.sub.22 is R.sub.12 or a lower alkyl; andR.sub.11 and R.sub.12 are each independently a hydrogen.