Patent ID: 8735630
Filing Date: 2014-05-27
Classification: B01J,C07B,C07C,C07D,C07F

Abstract:
1. A method represented by Scheme 3: wherein Z is selected from the group consisting of optionally substituted aryl, heteroaryl and alkenyl; X is selected from the group consisting of Cl, Br, I, —OS(O) W is selected from the group consisting of alkyl, —COOH, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, —(CH Z and W may be covalently linked; the transition metal is selected from the Group 10 metals; the base is selected from the group consisting of fluorides, hydrides, hydroxides, carbonates, phosphates, alkoxides, metal amides, and carbanions; and the ligand is selected from the group consisting of compounds represented by L: wherein R is selected independently for each occurrence from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, and —(CH R R R R R R R R M is an alkali metal or an alkali earth metal; R m is independently for each occurrence an integer in the range 0 to 8 inclusive; provided that at least one of R the ligand is achiral, or when chiral, is a single stereoisomer or a mixture of stereoisomers.