Patent ID: 6605639
Filing Date: 2003-08-12
Classification: A61K,A61P,C07D

Abstract:
A method for treating a disease or condition in a mammal which can be alleviated by the retinoid X receptor ligand (RXRL)-dependent regulation of gene transcription or inhibiting the infiltration of leukocytes into damaged arteries,wherein said disease or condition in a mammal which can be alleviated by the RXRL-dependent regulation of gene transcription, is arteriosclerosis in a human induced by serum cholesterol; wherein said method comprises: administering to said mammal a compound capable of acting as a retinoid X receptor ligand or a pharmaceutically acceptable salt thereof in an amount effective for treating said disease or condition or inhibiting the infiltration of leukocytes into damaged arteries, together with a pharmaceutically acceptable additive, wherein said compound is selected from the group consisting of: compounds of formula (1) wherein#R1R2R3R4R51â€”CHOHHClH2â€”CHOHHClâ€”OAc3â€”CHOHHBrH4â€”CHOHHHH5â€”CHOHCH3COâ€”ClH6â€”CHOHâ€”CH3ClH7â€”CHOâ€”CH3â€”CH3ClH8â€”CHOCH3COâ€”â€”CH3ClH9â€”CHOâ€”CH3CH3COâ€”ClH10â€”CHOâ€”CH3HClH11â€”CHOHCH3CH2â€”ClH12â€”CHOHallylClH13â€”CHOHbutylClH14â€”CHOHâ€”CH2COOHClH15â€”CHOHâ€”(CH2)2COOHClH16â€”CHOHâ€”(CH2)3COOHClH17â€”CHOHâ€”(CH2)4COOHClH18â€”CHOHâ€”CH2COOCH3ClH19â€”CHOHnicotinoylClH20â€”CHOHbenzoylClH21â€”CHOHisonicotinoylClHcompounds of formula (2) wherein#R1R222ClH23HH24Clâ€”OH25Clâ€”OAca compound of formula (3) a compound of formula (4) a compound of formula (5) compounds of formula (6) wherein#R1R229ClH30Clâ€”CH331ClCH3COâ€”32HH33Hâ€”CH334HCH3COâ€”and compounds of formula (7) wherein#R1R235ClH36Clâ€”CH337ClCH3COâ€”38HH39Hâ€”CH340HCH3COâ€”.