Patent ID: 8361509
Filing Date: 2013-01-29
Classification: A61K,A61P

Abstract:
1. A method for the prevention or treatment of a disease or disorder that is therapeutically responsive to one or more active principles, the method comprising: administering to a subject in need thereof a pharmaceutically effective amount of the one or more active principles, in a particulate vector, according to a predetermined dosing regimen, thereby providing a therapeutic response in the subject; wherein the particulate vector comprises at least one active principle and a polymeric matrix comprising a mixture of at least one biodegradable polymer and at least one non-water soluble polycationic polymer: the biodegradable polymer is selected from the group consisting of polyesters, lactic acid polymers, copolymers of lactic acid and of glycolic acid (PLGA), poly-ε-caprolactone (PCL), polyanhydrides, poly(amides), poly(urethanes), poly(carbonates), poly(acetals), poly(ortho-esters), polymers and copolymers derived from acrylic acid, polyethylene oxides, polypropylene oxides, polyethylene and polypropylene oxide copolymers, polycyanoacrylates, polydioxanones, poly(α-hydroxy acids), poly(β-hydroxy acids), and polyphosphazenes; the non-water soluble polycationic polymer is selected from the group consisting of polycationic chitosan, polycationic polylysine, cholestyramine and the polycationic copolymers of acrylic and methacrylic acid esters with trimethylammonioethyl methacrylate chloride; the active principle is selected from the group consisting of insulin, heparin, unfractionated heparin, low molecular weight heparin, ultra low molecular weight heparin, heparinoid, heparin having a molecular weight between 2,500 D and 40,000 D, antibiotics, anti-inflammatory agents, anti-infectious agents, antiparasitic agents, hormones, substances with immunological activity, vaccines, immunomodulators, immunosuppressants, cytostatic agents, diuretics, agents with activity in the digestive system, agents with activity in the circulatory system, agents with activity in the respiratory system, human growth hormone, recombinant growth hormone, bovine growth hormone, growth-hormone releasing hormone, interferons, analgesics, agents with activity in the central nervous system, erythropoietin, somatostatin, gonadotropin-releasin hormone, follicle-stimulating hormone, oxytocin, vasopressin, parathyroid hormone, adrenocorticotropin, gonadotropin-releasing hormone, thrombopoietin, calcitonin, interferons, interleukins, dermatan, glucosamines, chondroitins, auricular natriuretic factor monoclonal antibodies, protease inhibitors, filgrastim, prostaglandins (PGE2 and PGI2), cyclosporin, cromolyn sodium cromoglycate and its salts, vasopressin, vancomycin, neomycin, desferrioxamine, antimicrobial agents, antifungals, cytostatics, immunomodulators, vitamins, antivirals, antigens, ribonucleic acid, deoxyribonucleic acid, oligonucleotides, CPG sequences, plasmids, active compounds of protein nature, active compounds of polysaccharide nature glucocerebrosidase, and derivatives and combinations thereof; the biodegradable polymer and the polycationic polymer are present in equivalent amounts; and the biodegradable polymer and the polycationic polymer are non-enteric.