Patent ID: 7932366
Filing Date: 2011-04-26
Classification: C07C

Abstract:
1. A method for preparing a compound of the formula: where R 4 is H; and R 1 and R 3 are selected from the group consisting of H, CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , and C 1 -C 4 alkyl; and R 2 is: where R 5 , R 6 , R 7 and R 8 are independently hydrogen or C 1 to C4 alkyl; or the esters or pharmaceutically acceptable salts thereof, comprising: (a) converting a compound of one of the following formulas: (b) reacting the diazonium salt with a compound of one of the following formulas: (c) oxidizing the primary alcohol or aldehyde group to a carboxylic acid group, and (d) optionally forming an ester or pharmaceutically acceptable salt of one or more of the carboxylic acid groups.