Patent ID: 9201080
Filing Date: 2015-12-01
Classification: A61P,G01N

Abstract:
1. A method for determining whether a subject is at risk to develop one or more Cardiovascular Disease (CVD) complications, comprising: a. determining in a sample from said subject one or more lipid-lipid ratio(s), wherein (an) increased or decreased lipid-lipid ratio(s) in said sample, when compared to a control sample, is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-lipid ratio(s) whose increase(s) is (are) compared to the control is (are) selected from: Cer(d18:1/20:0)/PC 16:0/20:4, Cer(d18:1/24:1)/Total PC, Cer(d18:1/24:1)/PC 16:0/20:4, Total Cer/Total PC, and Cer(d18:1/18:0)/PC 16:0/20:4; and wherein the one or more lipid-lipid ratio(s) whose decrease(s) is (are) compared to the control is e) selected from: Cer(d18:0/22:0)/Cer(d18:1/24:1), Cer(d18:0/24:0)/Total CE, Cer(d18:0/24:0)/Cer(d18:1/24:1), Cer(d18:0/24:0)/Total Cer, Cer(d18:0/24:0)/Cer(d18:1/18:0), Cer(d18:0/24:0)/PS O-16:0/18:2-alkenyl, Cer(d18:0/24:0)/LacCer(d18:1/24:0), Cer(d18:0/22:0)/Cer(d18:1/18:0), Cer(d18:0/24:0)/Cer(d18:1/22:0), Cer(d18:0/22:0)/Cer(d18:1/20:0), Cer(d18:0/22:0)/PS O-16:0/18:2-alkenyl, and Cer(d18:0/22:0)/PS O-16:1/18:2-alkyl; or b. determining in a sample from said subject one or more lipid-clinical concentration ratio(s), wherein (an) increased or decreased lipid-clinical concentration ratio(s) in said sample, when compared to a control sample, is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-clinical concentration ratio(s) whose increase(s) is (are) compared to the control is (are) selected from: Cer(d18:1/20:0)/apolipoprotein A-I, Cer(d18:1/24:1)/apolipoprotein A-I, Total Cer/apolipoprotein A-I, Cer(d18:1/18:0)/apolipoprotein A-I, and Cer(d18:1/24:1)/apolipoprotein B; and wherein the one or more lipid-clinical concentration ratio(s) whose decrease(s) is (arc) compared to the control is (are) selected from: Cer(d18:0/24:0)/total cholesterol, Cer(d18:0/24:0)/apolipoprotein B, and Cer(d18:0/24:0)/apolipoprotein A-I.