Patent ID: 6727347
Filing Date: 2004-04-27
Classification: A61K,A61P

Abstract:
A polycation bioconjugate, comprising:one or more carrier molecules having free &agr;-amino groups, and one or more enhancer or connecting molecules, wherein the polycation bioconjugate has the general formula (I) â€ƒwherein â€œrâ€  is a mean value between 20 and 400 that designates the number of diaminomonocarbonic acyl group monomers; â€œmâ€ =0, 1, 2, 3, . . . ; [(k)Mx] designates enhancer molecules and/or connecting molecules linked by covalent (&boxH;k) bonds to a carrier molecule; [(i)Mx] designates enhancer molecules linked by ionic (&boxH;i) bonds to a carrier molecule, wherein the Mx functional groups may be the same or different, and the enhancer molecules can be linked directly and/or indirectly, through a connecting molecule, to the carrier molecule, and wherein when both [(k)Mx] and [(i)Mx] occur within the same polycation bioconjugate [(i)Mx]*[(k)Mx] is symbolized by [(k/i)Mx]; the carrier molecules are of the same configuration (either D- or L-), and the individual monomers are not linked together by their amino groups in the &agr;-positions, and are linked together by amino groups in other positions according to the value of m, wherein the carrier molecules have a general formula (I/a): â€ƒwherein [(k)Mx]=[(âˆ’)Cxj]p2 and at least one carrier molecule is linked with one or more connecting molecules [(âˆ’)Cxj] of anionic character, wherein the Cxj molecules may be the same or different, and are selected from the group consisting of dicarbonic acids, tricarbonic acids, carbohydrates, amino acids, and peptide chain elongators; wherein â€œ(âˆ’)Cxâ€  in â€œ[(âˆ’)Cxj]p2â€  designates (âˆ’)Cx connecting molecules of anionic character of different (â€œxâ€ ) kind linked to at least one carrier molecule of general formula (I/a) by covalent bonds; â€œjâ€  indicates whether the (âˆ’)Cx connecting molecules are identical (j=1) or different according to the number â€œjâ€  (j=2, 3, . . . ); and â€œp2â€  indicates a degree of saturation in % of a carrier molecule of general formula (I/a) by [(âˆ’)Cxj] connecting molecules of exclusively anionic character, p2 having a value which is >0 and &lE;100.