Patent ID: 8078322
Filing Date: 2011-12-13
Classification: C02F,G05B

Abstract:
1. A method for online regulation of a batch process in a bioreactor, comprising: recording high-dimensional spectra of a current batch by near-infrared range (NIR) spectrometry in the bioreactor at consecutive points in time during the batch process; creating a measuring vector for each spectrum in a low-dimensional primary component region through a primary component analysis of the high-dimensional spectra; determining a deviation between the measuring vector and a corresponding vector of a nominal trajectory which consists of measuring vectors of a reference batch determined in an earlier batch process; determining an adjustment operation for the batch process based on the deviation; and executing the adjustment operation in the batch process, wherein the direction of the adjustment operation is retained if the deviation determined from one point in time to another point in time is lower, and the direction of the adjustment operation is changed if the deviation determined from one point in time to another point in time remains the same or is greater.