Patent ID: 9056813
Filing Date: 2015-06-16
Classification: C07C

Abstract:
1. A process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IA comprising: (a) reacting a compound of Formula II with octanoyl halide to obtain a reaction mixture comprising a compound of Formula III and its corresponding regioisomer a compound of Formula IIIA; (b) hydrolyzing the reaction mixture resulting from step (a) to obtain a reaction mixture comprising a compound of Formula IV and its corresponding regioisomer a compound of Formula IVA; and isolating the compound of Formula IV which is free of its regioisomeric impurity compound of Formula IVA; (c) converting the compound of Formula IV resulting from step (b) to a compound of Formula III by subjecting to acetylation; (d) converting the compound of Formula III to a compound of Formula VI by subjecting to reduction and deacetylation; (e) converting the compound of Formula VI to a compound of Formula IX; and (f) converting the compound of Formula IX to fingolimod, a compound of Formula I or pharmaceutically acceptable salt thereof.