Patent ID: 6521776
Filing Date: 2003-02-18
Classification: A61K,A61P,C07F

Abstract:
A compound of the formula I: whereinR1 is selected from the group consisting of (a) â€”C(O)â€”; (b) â€”C(O)â€”C1-14 alkylene-C(O)â€” or â€”C(O)â€”C1-14 alkenylene-C(O)â€”, wherein the C1-14 alkylene or C1-14 alkenylene is optionally substituted with hydroxy, C1-6 alkoxy, C1-6 alkylenedioxy, carboxy, C1-6 alkoxycarbonyl, C1-6 carbamoyl, C1-6 acylamino, C1-6 alkylamino, or (aryl)C1-6 alkyl, wherein said aryl moiety of said (aryl)C1-6 alkyl is optionally substituted with C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, (C1-6 alkoxy)C1-6 alkylamino, (C1-6 alkylamino)C1-6 alkoxy, â€”Oâ€”C1-6 alkylene-NHâ€”C1-6alkylene-Oâ€”C1-6 alkyl, â€”Oâ€”C1-6 alkylene-NHâ€”C(O)â€”C1-6 alkylene-C(O)OH, or â€”Oâ€”C1-6 alkylene-NHâ€”C(O)â€”C1-6 alkylene-C(O)â€”C1-6 alkyl; (c) C2 to C15 straight or branched chain alkyl optionally substituted with hydroxy or alkoxy; and (d) â€”C(O)â€”C6-12 arylene-C(O)â€” wherein said arylene is optionally substituted with C1-6 alkyl, hydroxy, C1-6 alkoxy, halogen, nitro or amino; a and b are independently an integer from 0 to about 4; d and e are independently an integer from 1 to about 6; dâ€² and eâ€² are independently an integer from 0 to about 2; X1 and Y1 are independently selected from the group consisting of a null, oxygen, â€”NHâ€”, â€”N(C(O)C1-4 alkyl)-, and â€”N(C1-4 alkyl)-; G1, G2, G3, and G4 are independently selected from the group consisting of oxygen, methylene, â€”NHâ€”, â€”N(C1-4 alkyl)-, â€”N[C(O)â€”C1-4 alkyl]-, â€”NHâ€”C(O)â€”, â€”NHâ€” SO2â€”, â€”C(O)â€”Oâ€”, â€”C(O)â€”NHâ€”, â€”Oâ€”C(O)â€”, â€”Oâ€”C(O)â€”NHâ€”, â€”Oâ€”C(O)â€”Oâ€”, â€”NHâ€”C(O)â€”NHâ€”, â€”C(O)NHâ€”, C(O)N(C1-4 alkyl), and â€”S(O)nâ€”, where n is 0, 1, or 2; R2, R3, R4, R5, R6, and R7 are independently selected from the group consisting of: (a) C1 to C20 straight chain or branched chain alkyl which is optionally substituted with halo, oxo, hydroxy or alkoxy; (b) C2 to C20 straight chain or branched chain alkenyl, alkynyl, or dialkenyl which is optionally substituted with halo, oxo, hydroxy or alkoxy; and â€ƒwherein R8 is C1-6 straight or branched chain alkyl or C2-6 straight or branched chain alkenyl, alkynyl, or dialkenyl; G5 is selected from the group consisting of oxygen, methylene, arylene, â€”NHâ€”, â€”N(C1-4 alkyl)-, â€”N(C(O)â€”C1-4 alkyl)-, â€”NHâ€”C(O)â€”, â€”NHâ€”SO2â€”, â€”C(O)â€”Oâ€”, â€”C(O)â€”NHâ€”, â€”Oâ€”C(O)â€”, â€”Oâ€”C(O)â€”NHâ€”, â€”Oâ€”C(O)â€”Oâ€”, â€”NHâ€”C(O)â€”NHâ€”, and â€”S(O)nâ€”, where n is 0, 1, or 2; R9 and R10 are independently selected from the group consisting of (i) C1 to C20 straight chain or branched chain alkyl which is optionally substituted with halo, oxo, hydroxy or alkoxy; and (ii) C2 to C20 straight chain or branched chain alkenyl, alkynyl, or dialkenyl which is optionally substituted with halo, oxo, hydroxy or alkoxy; â€ƒor any one or two of G1R2, G2R4, G3R5, and G4R7 may together be a hydrogen atom or hydroxyl; or a pharmaceutically acceptable salt thereof.