Patent ID: 8329162
Filing Date: 2012-12-11
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A method of eliciting an antibody response or antigen-specific T-cell response in a mammal comprising: administering to said mammal a replication deficient lentivirus pseudotyped with a virus envelope comprising a modified E2 alphavirus glycoprotein comprising a modification that reduces binding of said E2 to heparan sulfate, wherein the lentivirus comprises a polynucleotide encoding an antigen wherein said polynucleotide is exogenous to the lentivirus genome, and wherein the lentivirus comprising the modified E2 alphavirus glycoprotein more efficiently transduces dendritic cells expressing DC-SIGN relative to cell types not expressing DC-SIGN, in an amount sufficient to elicit an antibody response or antigen-specific T-cell response to the antigen.