Patent ID: 6596283
Filing Date: 2003-07-22
Classification: A61K,A61P,Y10S

Abstract:
A method of immunizing a mammal against infection from bacteria selected from the group consisting of Neisseria meningitidis group B and E. coli K1, comprising administering to the mammal an immunizing amount of a vaccine composition of a conjugate molecule, comprising at least one polysaccharide having a structure of a modified group B Neisseria meningitidis polysaccharide, wherein the modification comprises substitution of N-acetyl groups of the group B Neisseria meningitidis polysaccharide with unsaturated acyl groups of Formula (II): and wherein R2 is an unsaturated C2-4 group comprising at least one double bond, and the polysaccharide is covalently bound to a protein.