Patent ID: 6852717
Filing Date: 2005-02-08
Classification: A61K,A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-isopropyl-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2,6-dimethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-3-[1,2,4]triazol-4-yl-phenyl)-3-[4-(pyrimidin-4-yloxy)-naphthalan-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-oxo-2H-pyran-4-yloxy)-naphthalen-1-yl]-urea; 5-tert-Butyl-2-methoxy-3-{3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-ureido}-benzoic acid; Carbonic acid 5-tert-butyl-2-methoxy-3-{3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-ureido}-phenyl ester methyl ester; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(4-isopropylamino-[1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[4-(cyclopropylmethyl-amino)-[1,3,5]triazin-2-yloxy]-naphthalen-1-yl}-urea; 1-[4-(4-Amino-[1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-([1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyclopropylamino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-ethylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(6-methyl-2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-[4-(2-Amino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyclopentylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[(pyridin-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-[4-(2-Benzylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-[4-(2-sec-Butylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-methoxy-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-dimethylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(6-methyl-2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-ethoxy-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-dimethylamino-ethoxy)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-[4-(2-Benzylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-3-[1,2,4]triazol-4-yl-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methanesulfinyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methylsulfanyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(2-Methoxy-5-trimethylsilanyl-phenyl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-methoxy-phenyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(3-methoxy-phenyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-phenyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidine-2-carboxylic acid methyl ester; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; and 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(tetrahydro-pyran-4-yloxy)-naphthalen-1-yl]-urea or the pharmaceutically acceptable salts thereof.