Patent ID: 8975430
Filing Date: 2015-03-10
Classification: C07B,C07C,C07F

Abstract:
1. A single step process for the synthesis of α-Aryloxy-α′-Azido/Alkoxy alcohols of general formula A with two stereocenters by phenolic kinetic resolution, wherein X is selected from N ‘R’ is selected independently from hydrogen, alkyl (C Y denotes O-tert-butyldimethylsilyl (OTBS) or phenyl; and ‘a’ and ‘b’ denote syn or anti position; wherein the said process comprising the steps of: (a) adding racemic epoxide of formula (1), to phenol of formula (2) wherein, X, Y and R are as defined above, at room temperature ranging between 25-35° C. to preformed (salen) Co (III) catalyst of formula 3, followed by addition of tertiary butyl methyl ether, stirring and adding pyridinium p-toluene sulfonate, filtering, concentrating, followed by purifying to obtain the α-Aryloxy-α′-Azido/Alkoxy alcohols of general formula A.