Patent ID: 6350774
Filing Date: 2002-02-26
Classification: A61P,C07D

Abstract:
A compound of formula I (or a pharmaceutically acceptable salt thereof) whereinA is carbonyl or methylene; D is CH, CRd or N in which Rd is hydroxy, methyl or methoxy; E is CH, CRe or N in which Re is methyl, methoxy or halo; R2 is â€”X2â€”(CH2)mâ€”NRaRb in which X2 is a direct bond, methylene, O or S; m is 1, 2, 3, 4 or 5; provided that when m is 1, then X2 is a direct bond; and Ra and Rb are independently hydrogen or (1-3C)alkyl or the group NRaRb is pyrrolidino, piperidino, or morpholino; R3 is â€”X3â€”(CH2)nâ€”Lâ€”Rc, â€”Oâ€”CHRfâ€”CHRfâ€”Rc, â€”Oâ€”N(Rg)2, â€”Sâ€”Rh or â€”COâ€”Ri in which X3 is a direct bond, methylene or 0; n is 1 or 2, provided that when n is 1, then X2 is a direct bond; L is â€”(CH2)kâ€” in which k is 0, 1, 2 or 3, or L is â€”(CHCH3)â€”; Rc is cyano, cyclopentyl, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, 2-oxoimidazolidin-1-yl, 3-methyl-2-oxoimidazolidin-1-yl, 2-oxopyrrolidin-3-yl, 1-methyl-2-oxopyrrolidin-3-yl, 1-tetrazolyl, methoxy, methylsulfonylamino or phenylsulfonylamino; or Rc is 2-methylthiazol-4-yl, CONRjRk or CONHNRjRk in which Ri is hydrogen, methyl or ethyl and Rk is hydrogen, methyl, ethyl or isopropyl; the two Rf groups together form a tetramethylene diradical so that the resulting 1,2-cyclohexanediyl group is trans; Rg is methyl or ethyl, Rh is 2-thiazolyl; and Ri is methoxy, dimethylamino or pyrrolidino; and R6 is hydrogen, hydroxy or methoxy.