Patent ID: 7427688
Filing Date: 2008-09-23
Classification: C07C

Abstract:
1. A method of producing a diphenylalanine compound represented by formula (4) or a salt thereof, which comprises: (a): reacting a diphenylmethylene halide compound represented by formula (1): wherein R n X is a chlorine atom, a bromine atom or an iodine atom, with a malonic acid diester compound represented by formula (2): wherein R P in at least one organic solvent selected from the group consisting of N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone, N,N-dimethylformamide, and mixtures thereof, in the presence of at least one base selected from the group consisting of an alkali metal hydride, an alkali metal t-butoxide, and mixtures thereof, to give a diester compound represented by formula (3): wherein each symbol is as defined above; and (b): subjecting said diester compound to hydrolysis and decarboxylation, to give said diphenylalanine compound represented by formula (4): wherein R P or a salt thereof.