Patent ID: 8835437
Filing Date: 2014-09-16
Classification: A61P,C07D

Abstract:
1. A compound of formula including any stereochemically isomeric form thereof, wherein A represents N; X represents —NR Z represents a bivalent radical selected from C R R R R R R R R R R aryl represents phenyl or phenyl substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl; carboxyl; halo; C Het represents a monocyclic non-aromatic or aromatic heterocycle selected from the group consisting of azetidinyl, pyrrolidinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, oxadiazolidinyl, triazolidinyl, thiadiazolidinyl, pyrazolidinyl, piperidinyl, hexahydropyrimidinyl, hexahydropyrazinyl, morpholinyl, thiomorpholinyl, and piperazinyl; said monocyclic heterocycle optionally being substituted with at least one substituent, each substituent independently being selected from hydroxyl; oxo; carboxyl; halo; C p represents 1 or 2; a N-oxide thereof, or a pharmaceutically acceptable salt thereof; provided that the following compounds are excluded.