Patent ID: 8647877
Filing Date: 2014-02-11
Classification: G01N,Y10T

Abstract:
1. A multi-component hematology control mixture which contains a nucleated red blood cell simulating particle for analyzing blood samples with a hematology analyzer comprising: isolated leukocytes or an isolated leukocyte subpopulation bound to a fluorescent-staining inhibitor, which binds to the nucleus or a nucleic acid in the leukocyte to reduce the binding capacity of the particle to a fluorescent dye used for detection of nucleated red blood cells in the hematology analyzer, wherein the fluorescent-staining inhibitor is selected from at least one of the following: a non-fluorescent dye; a fluorescent dye with a fluorescence quantum yield lower than that of the fluorescent dye used for detection in the hematology analyzer; a fluorescent dye with a fluorescence spectrum which differs from that of the fluorescent dye used for detection in the hematology analyzer in that it is either not excited by or not detected by the hematology analyzer; and a compound capable of binding to a nucleoside; combined with another blood cell simulating agent selected from at least one of simulated red blood cells, simulated leukocytes and simulated platelets, and a cell storage solution.