Patent ID: 6297266
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound of formula: ##STR57##whereinR.sup.1 is ##STR58##R.sup.2 is ##STR59##R.sup.3 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, carboxy, alkyl-O--CO-- or aralkyl-O--CO--;R.sup.4 is hydrogen, alkyl, cycloalkyl, aryl or heteroaryl;R.sup.5 and R.sup.6, independent of one another, are hydrogen, allcyl, cycloalkyl or heteroaryl;R.sup.7 and R.sup.8, independent of one another, are hydrogen, alkyl, cycloalkyl or heteroaryl or R.sup.7 and R.sup.8 together with the N atoms to which they are attached form a 5- to 8-membered heterocyclic or a 5- to 8-membered ring substituted with one or more alkyl substituents;R.sup.9 is hydrogen, alkyl or cycloalkyl;R.sup.10 is hydrogen, aryl, aralkyl, heteroaryl, heterocyclylalkyl, carboxyalkyl, alkyl, cycloalkyl, alkyl-O--CO--, aralkyl-O--CO--, alkyl CO--, alkylsulphonyl, arylsulphonyl or heteroarylsulphonyl;A is oxygen, sulphur, --CH.dbd.CH-- ##STR60##a to f are zero or whole positive integers, with a being zero to 2; b being zero to 4; c and d being zero or 1, with the proviso that c and d are not both simultaneously zero; e is zero to 5, with the proviso that e is other than zero when d is zero and e is zero to 3 when A is equal to --CH.dbd.CH--; and f is zero to 3, with the proviso that f is not zero when A is oxygen, sulphur or ##STR61##and their pharmaceutically usable salts and esters.