Patent ID: 6469032
Filing Date: 2002-10-22
Classification: A61P,C07D

Abstract:
A method of treating ocular disease comprising administering to a patient in need thereof a pharmaceutically acceptable amount of a compound having the formula: and pharmaceutically acceptable salt thereof, whereinR1 is H or alkyl; R2 is O or S; R3 is hydrogen; R4, R5, R6, R7 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO2NRRâ€², SO3R, SR, NO2, NRRâ€², OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2, and CONRRâ€²; R3â€², R5â€², and R6â€² are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO2NRRâ€², SO3R, SR, NO2, NRRâ€², OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, and CONRRâ€²; n is 0-3; X is Br, Cl, F or I; R is H, alkyl or aryl; and Râ€² is H, alkyl or aryl.