Patent ID: 7820398
Filing Date: 2010-10-26
Classification: A61P,G01N

Abstract:
1. A method for determining whether paroxysmal activity is the origin of seizures in patients diagnosed as having paroxysmal discharges, thereby distinguishing between epileptic and pseudo-epileptic seizures, and treating patients suffering from seizures of paroxysmal origin, comprising directly measuring the presence and quantity of GluR1 by assaying a biological fluid in said patients for GluR1 and GluR1 fragments, correlating greater than a predetermined amount of GluR1 and GluR1 fragments with paroxysmal origin of said seizures and, when said origin is paroxysmal, further comprising: a) treating said patient with an initial dose of anticonvulsive drug therapy; b) directly assaying said biological fluid for the presence and quantity of GluR1; c) increasing the dose, changing the drug, or treating with multiple drugs, if the quantity of GluR1 fails to fall below the predetermined amount of GluR1 and GluR1 fragments; and d) employing, as a control or calibrator, the GluR1 fragment of SEQ ID NO: 5 or 6 wherein the predetermined amount is at least 50 pg/ml.