Patent ID: 6492338
Filing Date: 2002-12-10
Classification: A61K,A61P,C07D

Abstract:
A method for treating a disease due to an aldose reductase activity or a disease complication of said disease, which comprisesadministering at least one compound having an aldose reductase inhibitory activity selected from the group consisting of 2,5-dihydroxytetrahydro-2-furancarboxylic acid of formula 1: as well as derivatives, optical isomers and pharmacologically acceptable salts thereof, wherein said derivatives are selected from the group consisting of compounds of formula 2: wherein R1, R2 and R3 may be the same of may be different from each other, and are hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group; m and n are 1 or 0, provided that in case of m=n=0, R1, R2 and R3 are not simultaneously hydrogen.