Patent ID: 6127551
Filing Date: 2000-10-03
Classification: A61K,C07C,C07D,C07F

Abstract:
A process of preparing a myxopyronin having the structure: ##STR40## which comprises: (a) reacting a pyrone having the structure: ##STR41## with propionyl chloride to form a ketone adduct having the structure: ##STR42## (b) (i) condensing the ketone adduct formed in step (a) with an aldehyde having the structure: ##STR43## to form a pyrone aldol; (ii) mesylating the pyrone aldol formed in step (b)(i) to form a pyrone aldol mesylate; and(iii) reacting the pyrone aldol mesylate to form a pyrone ketone having the structure: ##STR44## and (c)(i) saponifying the pyrone ketone formed in step (b)(iii) to form a pyrone acid;(ii) acylating the pyrone acid formed in step (c)(i) to form a pyrone anhydride;(iii) reacting the pyrone anhydride formed in step (c)(ii) with an azide salt to form a pyrone acyl azide; and(iv) heating the pyrone acyl azide formed in step (c)(iii) to form the myxopyronin.