Patent ID: 6207842
Filing Date: 2001-03-27
Classification: A61K,A61P,C07D,C07H

Abstract:
A process for the preparation of a procyanidin (4.fwdarw.8) dimer, comprising the steps of:(a) protecting each phenolic hydroxyl group of an epicatechin monomer to form a protected epicatechin monomer,(b) oxidizing the 4-position of the protected epicatechin monomer to form a protected dimer derivatized at the 4-position with a C.sub.2 -C.sub.6 alkoxy group having a terminal hydroxy group;(c) coupling the derivatized, protected epicatechin monomer with a protected catechin monomer or protected epicatechin monomer to form a protected procyanidin (4.fwdarw.8) dimer; and(d) deprotecting the protected procyanidin (4.fwdarw.8) dimer.