Patent ID: 6274758
Filing Date: 2001-08-14
Classification: C07B,C07C,C07D

Abstract:
A process for the preparation of an enantioenriched sulfone of formula (1), comprising asymmetric hydrogenation of a vinyl sulfone of formula (2) ##STR6##in the presence of a stereoselective chiral catalyst, wherein R.sup.1, R.sup.2, and R.sup.3 are each independently a hydrocarbon group of less than 20 carbon atoms, optionally substituted at any position, or either of R.sup.1 and R.sup.3 is H, and X is a coordinating group selected from the group consisting of CO.sub.2 H or a salt form thereof, CO.sub.2 R, CONHOH, CONH.sub.2, CONHR, and CONR.sub.2 and each R is independently a hydrocarbon substituent of up to 20 carbon atoms.