Patent ID: 8273554
Filing Date: 2012-09-25
Classification: C12N,C12P,C12Y,Y02P

Abstract:
1. A recombinant ketoreductase polypeptide capable of converting the substrate 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to the product (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one, which comprises an amino acid sequence that is at least 90% identical to a reference sequence of SEQ ID NO: 130, with the proviso that the amino acid sequence has at the residue corresponding to residue X145 a serine and at the residue corresponding to residue X190 a cysteine.