Patent ID: 9202009
Filing Date: 2015-12-01
Classification: G16B,G16H

Abstract:
1. A diagnostic support apparatus for diabetes comprising an input interface configured to receive an input of a laboratory value comprising a glucose concentration and an insulin concentration in a blood collected from a patient, a processor, and a memory that stores a biological model, which describes organ functions related to diabetes as a mathematical model which has a plurality of parameters, and which is divided into an insulin kinetic unit showing an insulin flow and a glucose kinetic unit showing a glucose flow, wherein the processor is programmed to: wherein the biological model includes organ blocks comprising: wherein the biological model is programmed such that a transfer of glucose and insulin in an interstitial fluid and blood plasma accompanying a blood circulation is represented in the liver block, the peripheral tissue block and the blood plasma block, wherein an inflow and an outflow of the glucose are reciprocally produced between the liver block and the blood plasma block in the glucose kinetic unit, and an inflow and an outflow of the glucose are reciprocally produced between the blood plasma block and the peripheral tissue block in the glucose kinetic unit, wherein an inflow and an outflow of the insulin are reciprocally produced between the liver block and the blood plasma block in the insulin kinetic unit, and an inflow and an outflow of the insulin are reciprocally produced between the blood plasma block and the peripheral tissue block in the insulin kinetic unit, wherein each of the liver block, the peripheral tissue block and the blood plasma block in the glucose kinetic unit calculates at least one of a cumulative quantity and a concentration of the glucose in each block based on a quantity of inflow and outflow of the glucose in each block in the glucose kinetic unit and a quantity of at least one of an increase and a decrease of glucose in each block in the glucose kinetic unit due to the respective function of each block respectively, wherein each of the liver block, the peripheral tissue block and the blood plasma block in the insulin kinetic unit calculates at least one of a cumulative quantity and a concentration of the insulin in each block, based on a quantity of inflow and outflow of the insulin in each block in the insulin kinetic unit and a quantity of at least one of an increase and a decrease of insulin in each block in the insulin kinetic unit due to the respective function of each block, respectively, and wherein the processor is further programmed to generate and output diagnostic support information of the patient comprising the indexes based on at least one of: the calculated cumulative quantity and the concentration of the glucose in each of the liver block, the peripheral tissue block and the blood plasma block in the glucose kinetic unit, and the calculated cumulative quantity and the concentration of insulin in each of the liver block, the peripheral tissue block, and the blood plasma block in the insulin kinetic unit.