Patent ID: 7227037
Filing Date: 2007-06-05
Classification: C07C,C07D

Abstract:
1. A process for the manufacture of a compound having the formula I wherein: X is cycloalkyl of 3 to 7 carbon atoms, which may be optionally substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally mono-, di-, or tri-substituted with a substituent selected from the group consisting of halogen, alkyl of 1–6 carbon atoms, alkenyl of 2–6 carbon atoms, alkynyl of 2–6 carbon atoms, azido, hydroxyalkyl of 1–6 carbon atoms, halomethyl, alkoxymethyl of 2–7 carbon atoms, alkanoyloxymethyl of 2–7 carbon atoms, alkoxy of 1–6 carbon atoms, alkylthio of 1–6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy of 2–7 carbon atoms, carboalkyl of 2–7 carbon atoms, phenoxy, phenyl, thiophenoxy, benzoyl, benzyl, amino, alkylamino of 1–6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, phenylamino, benzylamino, alkanoylamino of 1–6 carbon atoms, alkenoylamino of 3–8 carbon atoms, alkynoylamino of 3–8 carbon atoms, and benzoylamino; R R is alkyl of 1 to 3 carbon atoms; n is 0–1; Y is —NH—, —O—, —S—, or —NR R R  in which each R which process comprises: (a) preparing a N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acid compound by the process of oxidizing a N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamide compound having the structural formula  where R (b) converting the N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acid compound so prepared into a compound of formula I or an acid addition salt thereof, by: