Patent ID: 8475768
Filing Date: 2013-07-02
Classification: C07D

Abstract:
1. Compound of formula (I): wherein R W and the bonds represented as dotted lines are present or absent and when present, W is N; and X is a chelator moiety X consisting of a 6-membered aromatic or partially saturated ring system containing up to three heteroatoms selected from nitrogen and oxygen and having a hydroxyl group as a first substituent bound to a first atom in said ring system, and a hydroxyl group or an oxygen atom doubly bound to a second atom in said ring system wherein said first and second atom are adjacent atoms and wherein said first and second substituents are in ring positions such that X is capable of forming a complex with a paramagnetic metal ion; and wherein X is optionally substituted by up to three additional substituents, R, where each R is independently a hydrophilic group which renders the compound of formula (I) soluble in aqueous solutions.