Patent ID: 8663692
Filing Date: 2014-03-04
Classification: A61K,A61Q

Abstract:
1. An Ointment or lotion for topical application comprising lipid particles comprising a matrix prepared from a blend of a) a lipid which is solid at 37° C. (solid lipid) or a mixture of such solid lipids, and b) a lipid which has a melting point below 4° C. (liquid lipid) or mixtures of such liquid lipids, wherein, at 20° C., the particles are definite particles possessing a particle matrix structure which is not completely in the polymorphic, stable β-modification, the particle matrix comprises a predominant fraction of liquid lipid or lipid in the liquid crystalline state (α-modification), such that the particle matrix is less ordered compared to the bulk material of the initial solid lipid, the crystallinity index being below the crystallinity index of the initial solid lipid is below 0.5, and the average particle size being in the nanometer range of 30 to 1000 nm (0.03 to 1.0 μm), wherein the liquid lipid, or a mixture of liquid lipids, and the solid lipid, or a mixture of solid lipids, are mixed in a proportion of from 80+20 to 0.1+99.9.