Patent ID: 6730296
Filing Date: 2004-05-04
Classification: A61K,A61P,C07K

Abstract:
A polypeptide produced according to a process comprising:(a) growing a culture of a host cell in a suitable culture medium, wherein the host cell has been transformed with a polynucleotide comprising at least one expression control sequence, wherein the polynucleotide encodes a chimeric polypeptide, the chimeric polypeptide comprising at least one chemokine polypeptide covalently attached to at least one heterologous polypeptide, wherein the chemokine polypeptide comprises an amino acid sequence selected from the group consisting of: (aa) SEQ ID NO:1; (ab) SEQ ID NO:1 from amino acid 20 to amino acid 328; (ac) SEQ ID NO:1 from amino acid 21 to amino acid 328; (ad) SEQ ID NO:1 from amino acid 22 to amino acid 328; (ae) SEQ ID NO:3; and (af) SEQ ID NO:3 from amino acid 20 to amino acid 326, and (b) purifying said polypeptide from the culture.