Patent ID: 7199261
Filing Date: 2007-04-03
Classification: C07C,C12P,Y02P

Abstract:
1. A process for the preparation of the intermediate of formula VI wherein R a ′ and R c ′ are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R b is a carboxy-protecting group, which is suitable for the preparation of statin derivatives, which process is carried out by conversion of the intermediate of formula XIX wherein R a ′ and R c ′ are each independently of the other hydrogen or a hydroxy-protecting group, and R b is a carboxy-protecting group; wherein compound of formula XIX is prepared by a process which comprises the preparation of a compound of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )—OCH 3 , R a is hydrogen or a hydroxy-protecting group and R b is a carboxy-protecting group; wherein compound of formula I is prepared by conversion of a compound of formula XI wherein R a is a hydroxy-protecting group and R b is a carboxy-protecting group, into the corresponding compound of formula I using a reagent that introduces the radical X.