Patent ID: 7186397
Filing Date: 2007-03-06
Classification: A61K,A61P

Abstract:
1. A diagnostic, therapeutic or radiotherapeutic or chemotherapeutic composition for visualization, therapy, chemotherapy or radiotherapy of tissues or organs that overexpress folate-binding protein comprising: a) folate-receptor binding ligand comprising one or more folate-receptor binding moieties, at least one of which is conjugated through its alpha carboxylate via an optional linking group to one or more macrocyclic or non-macrocyclic metal-chelating ligand radicals that are optionally chelated to paramagnetic, superparamagnetic, radioactive or non-radioactive metals for detection outside the body by imaging means for diagnosis or for providing a therapeutic, chemotherapeutic, or radiotherapeutic effect; wherein said folate receptor binding ligand has the structure of formula II:  wherein R wherein —(A)p— and —(A)p*— are each independently optional linkers comprising a straight or branched chain wherein the moieties “A” are the same or different and selected from the group consisting of: —CH  and each R′ and R″ is independently a single bond, H, alkyl, alkoxy, cycloalkyl, hydroxyalkyl, aryl, or heterocyclo, each of which is optionally substituted, each R each R wherein wherein —[(A)p]—K  wherein all R and R* groups are independently —R wherein with the provisos that a carbon atom bearing an R group is not directly bonded to more than one heteroatom; and at least one R or R* group on each —K or a pharmaceutically acceptable salt thereof; in a pharmaceutically acceptable carrier.