Patent ID: 6437156
Filing Date: 2002-08-20
Classification: A61K,A61P,C07J

Abstract:
A compound selected from the group consisting of19-norchola-4,20-dien-3-one, 19-norchola-1,3,5(10),20-tetraen-3-ol, 19-norchola-4,20-dien-3&bgr;-ol, 19-norchola-1,3,5(10),6,20-pentaen-3-ol, 19-norchola-4,9,20-trien-3-one, 19-nor-3-hydroxychola-1,3,5(10),20-tetraen-6-one, 19-nor-10&bgr;-hydroxychola-4,20dien-3-one, 19-nor-3-methoxychola-2,5(10),20-triene, 19-norchola-1,3,5(10),7,20-pentaen-3-ol, 19-norchola-1,3,5,7,9,20-hexaen-3-ol, 19-norchola-5(10),20-dien-3&bgr;-ol, 19-norchola-1,3,5(10),20-tetraen-3,6&bgr;-diol, 19-norchola-5(10),20-dien-3-one, 19-norchola-1,3,5(10),9(11),20-pentaen-3-ol, 19,21-bisnorchola-4,17(20)-dien-3-one, 19,21-bisnorchola-4,17(20)-dien-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),6,17(20)-pentaen-3-ol, 19,21-bisnorchola-4,9,17(20)-trien-3-one, 19,21-bisnor-3-hydroxychola-1,3,5(10),17(20)-tetraen-6-one, 19,21-bisnor-10&bgr;-hydroxychola-4,17(20)-dien-3-one, 19,21-bisnor-3-methoxychola-2,5(10),17(20)-triene, 19,21-bisnorchola-1,3,5(10),7,17(20)-pentaen-3-ol, 19,21-bisnorchola-1,3,5,7,9,17(20)-hexaen-3-ol, 19,21-bisnorchola-5(10),17(20)-dien-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),17(20)-tetraen-3,6&bgr;-diol, 19,21-bisnorchola-5(10),17(20)-dien-3-one, 19,21-bisnorchola-1,3,5(10),9(11),17(20)-pentaen-3-ol, 19,21-bisnorchol-4-en-3-one, 19,21-bisnorchol-4-en-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),6-tetraen-3-ol, 19,21-bisnorchola-4,9-dien-3-one, 19,21-bisnor-3-hydroxychola-1,3,5(10)-trien-6-one, 19,21-bisnor-10&bgr;-hydroxychol-4-en-3-one, 19,21-bisnor-3-methoxychola-2,5-(10)-diene, 19,21-bisnorchola-1,3,5(10),7-tetraen-3-ol, 19,21-bisnorchola-1,3,5,7,9-pentaen-3-ol, 19,21-bisnorchol-5(10)-en-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10)-trien-3,6&bgr;-diol, 19,21-bisnorchol-5(10)-en-3-one, 19,21-bisnorchola-1,3,5(10),9(11)-tetraen-3-ol, 19,21-bisnorchola-4,16-dien-3-one, 19,21-bisncrchola-1,3,5(10),16-tetraen-3-ol, 19,21-bisnorchola-4,16-dien-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),6,16-pentaen-3-ol, 19,21-bisnorchola-4,9,16-trien-3-one, 19,21-bisnor-3-hydroxychola-1,3,5(10),16-tetraen-6-one, 19,21-bisnor-10&bgr;-hydrocxychola-4,16-dien-3-one, 19,21-bisnor-3-methoxychola-2,5(10),16-triene, 19,21-bisnorchola-1,3,5(10),7,16-pentaen-3-ol, 19,21-bisnorchola-1,3,5,7,9,16-hexaen-3-ol, 19,21-bisnorchola-5(10),16-dien-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),16-tetraen-3,6&bgr;-diol, 19,21-bisnorchola-5(10),16-dien-3-one, 19,21-bisnorchola-1,3,5(10),9(11),16-pentaen-3-ol, 19,21-bisnorchola-4,16-dien-20(22)-yn-3-one, 19,21-bisnorchola-1,3,5(10),16-tetraen-20(22)-yn-3-ol, 19,21-bisnorchola-4,16-dien-20(22)-yn-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),6,16-pentaen-20(22)-yn-3-ol, 19,21-bisnorchola-4,9,16-trien-20(22)-yn-3-one, 19,21-bisnor-3-hydroxychola-1,3,5(10),16-tetraen-20(22)-yn-6-one, 19,21-bisnor-10&bgr;-hydroxychola-4,16-dien-20(22)-yn-3-one, 19,21-bisnor-3-methoxychola-2,5(10),16-trien-20(22)-yne, 19,21-bisnorchola-1,3,5(10),7,16-pentaen-20(22)-yn-3-ol, 19,21-bisnorchola-1,3,5,7,9,16-hexaen-20(22)-yn-3-ol, 19,21-bisnorchola-5(10),16-dien-20(22)-yn-3&bgr;-ol, 19,21-bisnorchola-1,3,5(10),16-tetraen-20(22)-yn-3,6&bgr;-diol, 19,21-bisnorchola-5(10),16-dien-20(22)-yn-3-one, 19,21-bisnorchola-1,3,5(10),9(11),16-pentaen-20(22)-yn-3-ol, and 19,21-bisnor-3-methoxychola-1,3,5(10),16-tetraene.