Patent ID: 6706731
Filing Date: 2004-03-16
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinA or D is N, while the other is CH, and T is CH or CR4; or T is N and A or D is CH, while the other is CR4 and, with the proviso that at least one of A and D is CR4 when T is N; R4 is lower alkyl, lower alkenyl, lower alkylthio, mercapto, free, etherified or esterified hydroxy, unsubstituted, mono- or disubstituted amino or halogen; B and E, independently of one another, are each N or CH; G is C1-C6-alkylene, C2-C6-alkenylene, or hydroxy-substituted C1-C6-alkylene or C3-C6-alkenylene, n is 0 to 2; Q is lower alkyl, whereby A, D and T are not substituted by Q if they represent CR4; r is 0 to 5; R1 und R1â€² independently of one another are each hydrogen or lower alkyl; R2 and R3 a) independently of one another, are each lower alkyl; or b) together form a bridge of the part formula I*; â€ƒwherein the ring members T1, T2, T3 and T4, independently of one another, are each nitrogen or CH, and binding is achieved via the atoms T1 and T4, the bonds indicated by a wavy line, independently of one another, are each either single or double bonds, m is 0 to 4 and Z is a substituent of one or more carbon atoms, whereby Z is unsubstituted, mono- or disubstituted amino, halogen, unsubstituted or substituted alkyl, free, etherified or esterified hydroxy, nitro, cyano, free or esterified carboxy, alkanoyl, unsubstituted, N-mono- or N,N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl lower alkylsulfonyl or alkylphenylsulfonyl, whereby if more than 1 radical Z is present (m&gE;2), the substituents Z are identical or different; W is hydrogen, X is â€”N(R5); and R5 is H or lower alkyl; and Y is hydrogen, aryl, which is unsubstituted or substituted by one or more substituents, heterocyclyl, which is unsubstituted or substituted by one or more substituents or unsubstituted or substituted cycloalkyl; or a tautomer of the said compound; or an N-oxide of the said compound or tautomers thereof, whereby one or more N atoms carry an oxygen atom; or a salt of the said compounds.