Patent ID: 8318774
Filing Date: 2012-11-27
Classification: A61P,C07D

Abstract:
1. A substituted thiazoles of formula I, in which R or R R R or R or R or R m and n each represent 2, 3, 4, 5 or 6; or R or R p and q each represent 1, 2, 3, 4 or 5; or R or R r and s each represent 2, 3 or 4; or R t represents 1, 2, 3, 4 or 5; or R u represents 3 or 4; or R v and w independently of one another each represent 1, 2 or 3; R and R the aforementioned alkyl radicals are each branched or linear and have 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned alkenyl radicals are each branched or linear and have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned alkynyl radicals are each branched or linear and have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned heteroalkyl radicals, heteroalkenyl radicals and heteroalkynyl radicals each have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 members; the aforementioned heteroalkyl radicals, heteroalkenyl radicals and heteroalkynyl radicals each optionally have 1, 2 or 3 heteroatom(s), selected independently of one another from the group consisting of oxygen, sulphur and nitrogen, as chain member(s); the aforementioned alkyl radicals, alkenyl radicals, alkynyl radicals, heteroalkyl radicals, heteroalkenyl radicals and heteroalkynyl radicals may each be substituted with, as appropriate, 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —NO the aforementioned cycloalkyl radicals each have 3, 4, 5, 6, 7, 8 or 9 carbon atoms as ring members; the aforementioned cycloalkenyl radicals each have 3, 4, 5, 6, 7, 8 or 9 carbon atoms as ring members; the aforementioned heterocycloalkyl radicals each have 3, 4, 5, 6, 7, 8 or 9 members; the aforementioned heterocycloalkenyl radicals each have 4, 5, 6, 7, 8 or 9 members; the aforementioned heterocycloalkyl radicals and heterocycloalkenyl radicals each optionally have 1, 2 or 3 heteroatom(s), selected independently of one another from the group consisting of oxygen, sulphur and nitrogen (NH), as chain member(s); the aforementioned cycloalkyl radicals, heterocycloalkyl radicals, cycloalkenyl radicals or heterocycloalkenyl radicals may each be substituted with, as appropriate, 1, 2, 3, 4 or 5 substituents selected independently of one another from the groups consisting of F, Cl, Br, I, —CN, —CF the aforementioned alkylene radicals are each branched or linear and have 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned alkenylene radicals are each branched or linear and have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned alkynylene radicals are each branched or linear and have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms as members of the chain; the aforementioned heteroalkylene radicals, heteroalkenylene radicals and heteroalkynylene radicals each have 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 members; the aforementioned heteroalkylene, heteroalkenylene and heteroalkynylene groups each optionally have 1, 2 or 3 heteroatom(s), selected independently of one another from the group consisting of oxygen, sulphur and nitrogen (NH), as chain member(s); the aforementioned alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene or heteroalkynylene groups may each be unsubstituted or substituted with, as appropriate, 1, 2, 3, 4 or 5 substituents selected independently of one another from the group consisting of phenyl, F, Cl, Br, I, —NO the aforementioned aryl radicals are monocyclic or bicyclic and have 6, 10 or 14 carbon atoms; the aforementioned heteroaryl radicals are monocyclic, bicyclic or tricyclic and have 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 members; the aforementioned heteroaryl radicals with 5 to 14 members optionally have 1, 2, 3, 4 or 5 heteroatom(s), selected independently of one another from the group consisting of oxygen, sulphur and nitrogen (NH), as chain member(s); and the aforementioned phenylene radicals, aryl radicals and heteroaryl radicals may each be substituted with, as appropriate, 1, 2, 3, 4 or 5 substituents selected independently of one another from the group consisting of F, Cl, Br, I, —CN, —NO each optionally in the form of one of the pure stereoisomers, or the racemate thereof, or in the form of a mixture of stereoisomers mixed in any ratios, or each in the form of a corresponding salt.