Patent ID: 8637046
Filing Date: 2014-01-28
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A composition, comprising: a) a live BHV-1 that has modifications of UL49.5 and at least one additional gene encoding protein that can affect a host immunological response to an immunogen; and b) an additional immunogen which is not encoded by a foreign gene inserted in the genome of the live BHV-1, where following administration of the composition to a host, a ratio of IgG1/IgG2 for IgG specific for the additional immunogen in the host is higher than a ratio of IgG1/IgG2 for IgG specific for the additional immunogen in a host administered a composition of live BHV-1 that does not have the modifications and the additional immunogen.