Patent ID: 6184013
Filing Date: 2001-02-06
Classification: A61K,A61P,C07D,C07F,C07K,C12N

Abstract:
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure: ##STR61##wherein each of R.sub.1, R.sub.2, R.sub.3, or R.sub.4 is independently hydrogen, or a lower alkyl; or wherein one but only one of R.sub.1, R.sub.2, or R.sub.3, is a lower alkyl substituted on the terminal carbon atom by an azido or amino group, a group comprising a lower alkyl group linked to a lower carboxylic acid or carboxylic acid derivative, wherein the carboxylic acid derivative is an amide or ester, with each of the remaining two of R.sub.1, R.sub.2, or R.sub.3 is independently hydrogen or a lower alykl and R.sub.4 is hydrogen, a lower alkyl or a negative charge.