Patent ID: 7851432
Filing Date: 2010-12-14
Classification: A61K,A61P,C07D

Abstract:
1. A maytansinoid-cell-binding agent conjugate, wherein the maytansinoid is represented by formula 4 1 ′: wherein: Y R A, B, and D, each independently is cycloalkyl or cycloalkenyl having 3-10 carbon atoms, simple aryl or aryl substituted with at least one alkyl containing from 1-4 carbon atoms, or an alkoxy, halogen or nitro, or heterocyclic aromatic or heterocyclic radical; R l, m, n, o, p, q, r, s, t and u are each independently 0 or an integer of from 1 to 5; , provided that at least two of l, m, n, o, p, q, r, s, t and u are not zero at any one time, wherein said heterocyclic aromatic radical or said heterocyclic radical is a 3-10 membered ring containing one or two heteroatoms selected from N, O or S.