Patent ID: 8791300
Filing Date: 2014-07-29
Classification: B01J,C07C

Abstract:
1. A process for preparing a substituted dimethyl-(3-arylbutyl)amine compound corresponding to formula III: wherein R R R R R R R R said process comprising: (a) choosing a homogeneous catalyst comprising a soluble rhodium salt or rhodium complex including an appropriate chiral diphosphine ligand with two secondary phosphine groups to prepare a specific diastereomer of a compound of formula III in a ratio of greater than or equal to 70:30 in favor of the specific diastereomer; and (b) reacting a substituted dimethyl-(3-arylbut-3-enyl)amine compound corresponding to formula II: or a salt thereof, wherein R R R R in the presence of hydrogen and the homogeneous catalyst having the appropriate chiral diphosphine ligand, wherein the chiral diphosphine ligands is: to prepare the specific diastereomer of the compound of formula III in the ratio of greater than or equal to 70:30 in favor of the specific diastereomer.