Patent ID: 6589766
Filing Date: 2003-07-08
Classification: C12N,C12P

Abstract:
A method for catalyzing a retroaldol reaction for converting a &bgr;-hydroxy ketone into a first and a second carbonyl product, said first and second carbonyl products being both a ketone product or both an aldehyde product, the method comprising the following steps:Step A: admixing a catalytically effective amount of a catalytic antibody having aldol addition activity or of a catalytically active molecule containing an antibody combining site portion of said catalytic antibody with said &bgr;-hydroxy ketone in a reaction medium for producing a reaction admixture, said catalytic antibody or said catalytically active molecule being of the type which includes a lysine residue which forms a Schiff base intermediate with said first carbonyl product, said first carbonyl product being unbranched at an &agr; position; and then Step B: maintaining said reaction admixture of said Step A for a period of time sufficient for said catalytic antibody or said catalytically active molecule to catalyze said retroaldol reaction for converting said &bgr;-hydroxy ketone to said first and second carbonyl products.