Patent ID: 7101860
Filing Date: 2006-09-05
Classification: A61K,A61P,C07H

Abstract:
1. A method of preventing or treating diseases or conditions associated with platelet aggregation comprising: administering to a subject a pharmaceutical composition comprising a therapeutically effective amount of a P2Y wherein: X T m=0, 1 or 2; n 0 or 1; p=0, 1, or 2; where the sum of m+n+p is from 0 to 5; M=H or a pharmaceutically-acceptable inorganic or organic counterion; D Y′=OR Z′=OR R wherein: O is the corresponding 2′ and/or 3′ oxygen of the furanose or carbocycle; C is a carbon atom; R R R R R R wherein: the two O-groups are the 2′ and 3′ oxygens of the furanose or carbocycle; and the 2′ and 3′ oxygens of the furanose or carbocycle are linked by the common carbon atom to form a cyclical acetal, cyclical ketal, or cyclical orthoester; and for cyclical acetals and ketals, R for cyclical orthoesters, R A is a nucleoside residue defined as: and linked to the phosphate chain via the 5′ position of the furanose or carbocycle; wherein: D Z=H, OH, or OR Y=H, OH, or OR R B and B′ are independently a purine or a pyrimidine residue according to general Formulae IV and V which is linked to the 1′ position of the furanose or carbocycle via the 9- or 1- position of the base, respectively; wherein: R R when R J is carbon or nitrogen, with the provision that when nitrogen, R R R R R R