Patent ID: 6667337
Filing Date: 2003-12-23
Classification: A61K,A61P

Abstract:
A method of treating cancer, the method comprising the step of administering to a mammal in need of such treatment, either simultaneously or sequentially, an effective amount of (i) a compound which is paclitaxel or docetaxel, and (ii) a compound of the formula or a pharmaceutically acceptable salt or ester thereof; wherein R1, R2 and R3 are each independently selected from the group consisting of H, C1-C6 alkyl, halogen, CF3, CN, NO2, NH2, OH, OR, NHCOR, NHSO2R, SR, SO2R and NHR wherein each R is independently C1-C6 alkyl optionally substituted with one or more substituents selected from hydroxy, amino and methoxy, and wherein each of R1, R2 and R3 may be present at any of the available positions 1 to 8; and wherein in each of the carboxylic aromatic rings in formula (I), up to two of the methine (â€”CH&boxH;) groups may be replaced by an aza (â€”N&boxH;) group; and wherein any two of R1, R2 and R3 may additionally together represent the group â€”CH&boxH;CHâ€”CH&boxH;CHâ€”, such that this group, together with the carbon or nitrogen atoms to which it is attached, forms a fused 6 membered aromatic ring, wherein said cancer is sensitive to the combination of (i) and (ii), and wherein an anticancer effect is achieved with a combination of a compound of formula (I) and paclitaxel which is larger than the anticancer effect achieved with either said compound of formula (I) or paclitaxel alone and exceeds the sum of the effects of said compound of formula (I) and paclitaxel, and wherein an anticancer effect is achieved with a combination of a compound of formula (I) and docetaxel which is larger than the anticancer effect achieve with either said compound of formula (I) or docetaxel alone and exceeds the sum of the effects of said compound of formula (I) and docetaxel.