Patent ID: 7572909
Filing Date: 2009-08-11
Classification: C07H,Y02P

Abstract:
1. A method for producing 2-chloro-2′-deoxyadenosine comprising the steps of: (a) converting the 6-oxo group of a compound having the formula  wherein R is a protecting group selected from the group consisting of acyl and silyl, into a 6-(substituted oxy) group having sufficient reactivity in an S (b) replacing the 2-amino group with a 2-chloro group by a diazotization/chloro-dediazoniation reaction; (c) replacing the 6-(substituted oxy) leaving group with a 6-amino group; and (d) removing the R protecting groups, to produce 2-chloro-2′-deoxyadenosine; wherein replacing the 2-amino group with a 2-chloro group by a diazotization/chloro-dediazoniation reaction is performed using acetyl chloride and benzyltriethylammonium nitrite.