Patent ID: 6689778
Filing Date: 2004-02-10
Classification: A61P,C07D

Abstract:
A compound of formula IIIa: or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from halogen, NO2, TyR, or TCN; each T is independently selected from an optionally substituted C1-C6 alkylidene chain, wherein: one methylene unit of T is optionally replaced by O, NR, NRC(O), C(O)NR, NRC(O)NR, C(O), C(O)CH2C(O), C(O)C(O), C(O)O, OC(O), NRSO2, S, SO, SO2NR, or SO2; y is zero or one; each R is independently selected from hydrogen or an optionally substituted C1-C6 aliphatic group, or: two R on the same nitrogen are taken together with the nitrogen to form a 3-7 membered saturated, partially unsaturated, or fully unsaturated ring having 1-2 heteroatoms, in addition to the nitrogen bound thereto, independently selected from nitrogen, oxygen, or sulfur; R2 is R or Ar1; G is selected from XmR or XmAr1; each m is independently selected from zero or one; X is selected from O, S, SO, SO2, NH, C(O), C(O)NH, NHC(O), NHC(O)NH, SO2NH, NHSO2, or NHSO2NH; each Ar1 is independently selected from an optionally substituted ring selected from a 5-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Q is an optionally substituted C1-C6 alkylidene chain wherein: one or two non-adjacent methylene units of Q are optionally and independently replaced by O, NR, NRC(O), C(O)NR, C(O), S, SO, SO2, or SO2NR; each n is independently selected from zero or one; R4 is independently selected from R, halogen, NO2, CN, OR, SR, N(R)2, NRC(O)R, NRC(O)N(R)2, NRCO2R, C(O)R, CO2R, OC(O)R, C(O)N(R)2, OC(O)N(R)2, SOR, SO2R, SO2N(R)2, NRSO2R, NRSO2N(R)2, C(O)C(O)R, or C(O)CH2C(O)R, R5 is Ar1, wherein R5 is optionally substituted with up to three R6; each R6 is independently selected from R, halogen, NO2, CN, OR, SR, N(R)2, NRC(O)R, NRC(O)N(R)2, NRCO2R, C(O)R, CO2R, C(O)N(R)2, OC(O)N(R)2, SOR, SO2R, SO2N(R)2, NRSO2R, NRSO2N(R)2, C(O)C(O)R, or C(O)CH2C(O)R, or: two R6 on adjacent positions of R5 are taken together to form a saturated, partially unsaturated, or fully unsaturated 5-7 membered ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and provided that when R1 is hydrogen, R5 is other than phenyl.