Patent ID: 8398978
Filing Date: 2013-03-19
Classification: A61K,A61P,C07K

Abstract:
1. A method for treating a disease associated with aberrant deposition of β-amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β-amyloid peptide or an aggregated form of a β-amyloid peptide, wherein the antibody binds to an epitope on Aβ 1-40 that includes amino acids 25-34 and 40, wherein the antibody binds to Aβ 1-40 with higher affinity than its binding to Aβ 1-42 and Aβ 1-43 , wherein the antibody binds to Aβ 22-37 with a K D of less than 1 μM, and wherein the antibody comprises a heavy chain variable region comprising three CDRs at least 97% identical to the three CDRs from the heavy chain variable region shown in SEQ ID NO:1, and a light chain variable region comprising three CDRs at least 96% identical to the three CDRs from the light chain variable region shown in SEQ ID NO:2.