Patent ID: 8426378
Filing Date: 2013-04-23
Classification: A61K,C07H,C12N

Abstract:
1. A method comprising administering an oligomeric compound to an animal, wherein said oligomeric compound is a gapped oligomeric compound comprising two external regions separated by an internal region, wherein the internal region comprises about 8 to about 12 contiguous β-D-2′-deoxyribonucleosides and each external region comprises from 1 to 3 contiguous tricyclic nucleosides wherein each tricyclic nucleoside has formula II: wherein independently for each of said tricyclic nucleoside having formula II: Bx is a heterocyclic base moiety; one of T q1, q2, q3 and q4 are each, independently, H, halogen, C z1 and z2 are each, independently, H, halogen, C wherein each substituted group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, N wherein said oligomeric compound comprises monomeric subunits that are linked by phosphorothioate internucleoside linking groups and wherein said oligomeric compound is complementary to at least a portion of a target RNA.