Patent ID: 6673834
Filing Date: 2004-01-06
Classification: C07D,C12N,C12P,C12R

Abstract:
A compound of formula I including all stereoisomeric forms of said compound of formula I, mixtures of said forms and compounds in any ratio, and/physiologically tolerated salts thereof, wherein:R1, R2, R3, R4, R5, R6, R7, R8, R10 and R11 are independently selected from the group consisting of hydrogen; (C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted by one, two or three substituents selected from the group consisting of halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; (C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; (C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; â€”Oâ€”R9, in which R9 is selected from the group consisting of: (C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; (C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; (C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”OH; &boxH;O; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: halogen; â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”OH and â€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen; â€”C(O)â€”OH; â€”C(O)â€”Oâ€”NH2; â€”C(O)â€”Oâ€”(C1-C4)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH; and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NHâ€”(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of: â€”CN; â€”NH2; &boxH;Nâ€”OH and &boxH;Nâ€”Oâ€”(C1-C6)-alkyl, in which alkyl is a straight or branched chain; â€”NH2 and halogen; â€”NHâ€”R9, in which R9 is as defined above; â€”NHâ€”C(O)â€”H; â€”NHâ€”C(O)â€”R9, in which R9 is as defined above; â€”NH-aryl, in which aryl is unsubstituted or independently substituted one, two or three times by R9, in which R9 is as defined above: &boxH;Nâ€”OH; &boxH;Nâ€”Oâ€”R9, in which R9 is as defined above; â€”Sâ€”H; â€”Sâ€”R9, in which R9 is as defined above; â€”S(O)â€”R9, in which R9 is as defined above; â€”S(O)2â€”R9, in which R9 is as defined above; and â€”SO2, with the following further alternatives to the foregoing definition: a) either R4 and R5 or R10 and R11, together with the carbon atoms to which they are,respectively, bonded, may form a 3-, 4-, 5- or 6-membered heteroalkyl or heteroaryl ring system which contains one or two heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; and b) the bond between the ring carbons indicated as â€”C14-C15â€” in formula I may be either a single bond or a double bond; and the further proviso that: c) R7 is not hydrogen.