Patent ID: 8440693
Filing Date: 2013-05-14
Classification: A61P,C07D

Abstract:
1. A compound of formula (I), or pharmaceutically acceptable salt thereof, wherein Z is CH X is halogen; R H— R′O— (R′) R R′O— (R′) each R′ is independently selected from the group consisting of H— C C halo-C halo-C C heterocyclyl- aryl- hydroxy-C C amino-C N—C N,N-di-C C aryl-C C halo-C hydroxy-C C amino-C N—C N,N-di-C C heterocyclyl-C aryl-C C heterocyclyl-carbonyl- aryl-carbonyl- C halo-C hydroxy-C C amino-C N—C N,N-di-C C heterocyclyl-carbonyl-C aryl-carbonyl-C carbonyl-C hydroxy-carbonyl-C C amino-carbonyl-C N—C N,N-di-C C heterocyclyl-carbonyl-C aryl-carbonyl-C C C halo-C halo-C each R halogen- cyano- nitro- C C halo-C hydroxy- C amino- N—C N,N-di-C amino-carbonyl-amino- N—C N,N-di-C C amino-carbonyl- N—C N,N-di-C hydroxy-C amino-C N—C N,N-di-C C C n is 0 to 2; R and wherein said phenyl, 2-pyridyl or 3-pyridyl is optionally substituted by 1-2 additional substituents selected from halogen- cyano- C halo-C hydroxy- C hydroxy-C or (B) phenyl, 2-pyridyl or 3-pyridyl or (C) phenyl, (D) (C-bound)-heterocycle selected from (E) pyrazin-2-yl, substituted at the 5 position by: (F) pyridazin-3-yl, substituted at the 6 position by: (G) pyrimidin-2-yl, substituted at the 5 position by: wherein each R 3 is independently selected from H— C hydroxy-C C C amino-C N—C N,N-di C (R (R (R (R R R R R R (R C hydroxycarbonyl-C amino-carbonyl-C R (R R aryl-C heterocyclyl-C C halo-C heterocyclyl-carbonyl- aryl-carbonyl- C C heterocyclyl- aryl- or two R halogen- hydroxy-C C halo-C oxo= hydroxy- C amino- N—C N,N-di-C hydroxy-carbonyl- C amino-carbonyl- N—C N,N-di-C C C heterocyclyl- C C each R 5 is independently selected from: H— C hydroxy-C C C amino-carbonyl-C N—C N,N-di-C C amino-sulfonyl- N—C N,N-di-C heterocyclyl-carbonyl- amino-carbonyl- N—C N,N-di-C C C C C C hydroxy-C or two R C oxo=, C C hydroxy-C with the proviso that if Z is CH 2 , n is 0 or 1, and when present, R 1 is ortho-chloro, and R 2 is selected from para-C para-(halo-C para-C para-halo-phenyl- para-nitro-phenyl- para-(C para-(hydroxy-carbonyl)-phenyl- wherein the phenyl is optionally substituted by 1-2 additional substituents, said substituents being independently selected from halo and methyl, then R 6 and R 7 are not both ethoxy or methoxy, aryl means phenyl or naphthyl, and heterocyclyl means an unsaturated, saturated, or partially saturated ring or ring system comprising 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 ring atoms, and containing at least one heteroatom selected from N, O and S, where the N and S can also optionally be oxidized, and wherein, unless otherwise stated, the heterocyclic group can be attached at a heteroatom or a carbon atom.