Patent ID: 8668935
Filing Date: 2014-03-11
Classification: A61B,A61K,A61N,B82Y

Abstract:
1. A method of simultaneously providing localized internal ionizing radiation therapy in combination with thermal therapy to a target site in a patient in need thereof, the method comprising administering to the patient a composition of nanoparticles, the nanoparticles containing at least one radioactive isotope and coated with anti-tumor antibodies, the nanoparticles forming an antibody labeled nanoparticle-cell complex at a target site, the radioactive nanoparticle resulting in radiation therapy at a dose sufficient to damage tumor-associated vessels at the localized target site, and administering localized thermal therapy at the target site essentially simultaneously during the radiation therapy in the absence of an ultrasound contrast agent by exposing the target site to an energy source to generate a photoacoustic signal producing conditions at the target site sufficient to heat the nanoparticle-cell complex to hyperthermally treat cells wherein the hyperthermal treatment damages or kills cells at the target site.