Patent ID: 6020362
Filing Date: 2000-02-01
Classification: A61P,C07C,C07D

Abstract:
A prodrug derivative of a bicyclic compound having a nucleus formed from two fused six membered rings, A and B, represented by the formula (Xd): ##STR241## wherein; the bicyclic nucleus of rings A and B is formula (17) below: ##STR242## n is a number from 0 to 6; R.sub.0 is the same or different and is independently selected from hydrogen, alkyl, halosubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, hydroxy, alkoxy, aralkoxy, amino, substituted amino, carbamoyl, carboxy, acyl, cyano, halo, nitro, sulfo, .dbd.O, and .dbd.S;m is a number from 0 to 6;R.sub.10 is the same or different and is independently selected from hydrogen, alkyl, halosubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, hydroxy, alkoxy, aralkoxy, carboxy, acyl, cyano, halo, nitro, sulfo, .dbd.O, and .dbd.S; with the proviso that only one R.sub.10 may be .dbd.O or .dbd.S;linking group --(L)-- is a bond or a divalent substituted or unsubstituted chain of from 1 to 10 atoms selected from the group consisting of carbon, nitrogen, sulfur, and oxygen; and;Q.sub.2 is selected from (i) a basic group containing a basic radical, or (ii) a basic group containing an acylated basic radical;R.sub.13 is selected from (i) an acidic group containing an acid radical, or (ii) an acidic group containing an ester derivative of an acid radical;provided that Q.sub.2 is a basic group containing an acylated basic radical or R.sub.13 is an acidic group containing an ester derivative of an acid radical.