Patent ID: 8378092
Filing Date: 2013-02-19
Classification: A61P,C07D

Abstract:
1. A compound of the formula I, wherein  is a thiophenyl residue, X is halogen, methyl or ethynyl, R1, R2 and R3 are independent of one another are identical or different and are a hydrogen atom, —(C —(C —(C 1) hydrogen atom, 2) —(C 3) —(C 4) —SO 5) —(C 6) —(C 7) —O—(C 8) —(C provided that R4 and R5 are not each a hydrogen atom, or R4 and R5 together with the nitrogen atom to which they are bonded form a 4- to 10-membered mono- or bicyclic heterocyclic ring which in addition to the nitrogen atom can contain one, two or three identical or different ring heteroatoms chosen from oxygen, sulfur and nitrogen, wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R7, R6 is 1) heterocyclyl, wherein heterocyclyl is as defined above and is un-substituted or mono-, di- or trisubstituted independently of one another by R8 or R7 is halogen, —NO —(C —(C R8 is halogen, —NO R9 and R11 are the same or different and are independently of one another hydrogen, —(C R10 and R20 are the same or different and are independently of one another hydrogen atom, halogen, —(C —(C —(C —(C R12 is —(C R13 is hydrogen atom, —OH or —O—(C R14 and R15 are the same or different and are independently of one another hydrogen atom or —(C R16 is hydrogen atom, —OH or —O—(C R21 and R22 are the same or different and are independently of one another 1) hydrogen atom, 2) —(C 3) —(C 4) —SO 5) —(C 6) —(C 7) —O—R12 or 8) —(C R21 and R22 together with the nitrogen atom to which they are bonded form a 4- to 10-membered mono- or bicyclic heterocyclic ring which in addition to the nitrogen atom can contain one, two or three identical or different ring heteroatoms chosen from oxygen, sulfur and nitrogen, wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R8, and R23 is hydrogen atom, —OH or —O—(C or a stereoisomeric form thereof, or a physiologically tolerable salt of any of these.