Patent ID: 8178291
Filing Date: 2012-05-15
Classification: A61P,C12Q

Abstract:
1. A method for determining whether an human immunodeficiency virus 1 (HIV-1) is hypersusceptible to a non-nucleoside reverse transcriptase inhibitor (NNRTI), comprising detecting in a gene encoding reverse transcriptase of the HIV-1 the presence of a mutation at codon 65, wherein the codon number of said HIV-1 corresponds to the codon number in the wild type HIV-1 isolate NL4-3, wherein the mutation at codon 65 encodes arginine (R) instead of lysine (K), and wherein the presence of the mutation correlates with hypersusceptibility to a NNRTI, thereby determining whether the HIV-1 is hypersusceptible to the NNRTI.