Patent ID: 6677336
Filing Date: 2004-01-13
Classification: A61P,C07D

Abstract:
A substituted piperazine compound having the following formula: wherein m=1 or 2; R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, halo, CF3, CN, OR23, SR23, N(R23)2, SO2N(R23)2, COR23, C1-15 straight or branched alkyl, C2-15 straight or branched alkenyl, morpholino, and pyrrolyl, wherein the alkyl substituent is optionally substituted with 1 substituent selected from the group consisting of OR23, wherein R2 and R3 may join together to form a fused ring system wherein the two R groups together consist of from three to four carbon atoms, and wherein R4 and R5 may join together to form â€”CH&boxH;CHâ€”CH&boxH;CHâ€”; R6, R7 and R8 are each hydrogen; R9, R10, R11, R12, R13, R14, R15 and R16 are each independently selected from the group consisting of hydrogen, and C1-4 straight or branched alkyl, wherein R9 and R10 may together form a carbonyl, or R11 and R12 may together form a carbonyl, or R13 and R14 may together form a carbonyl, or R15 and R16 may together form a carbonyl with the proviso that R9, R10, R11, R12, R13, R14, R15 and R16 are not all simultaneously hydrogen; R17, R18, R19, R20, and R21 are each independently selected from the group consisting of hydrogen, halo, OR23, C1-15 straight or branched alkyl, and phenyl; and R23 is selected from the group consisting of H and C1-15 straight or branched alkyl.