Patent ID: 6331636
Filing Date: 2001-12-18
Classification: A61P,C07C,C07D

Abstract:
A compound having the formula ##STR22##wherein,R.sub.1 is from the group --(CO)het and het wherein het is a five atom heterocyclic aromatic ring containing nitrogen, carbon, or optionally containing an additional heteroatom oxygen;R.sub.2 and R.sub.3 is independently selected from(a) hydrogen(b) C.sub.1-8 alkyl(c) C.sub.2-8 alkenyl(d) C.sub.2-8 alkynyl(e) (CH.sub.2).sub.m --C.sub.3-8 cycloalkyl(f) (CH.sub.2).sub.m --C.sub.3-8 cycloalkenyl(g) (C.sub.2).sub.m -aryl(h) trimethylsilylmethyl(i) allylR.sub.4 and R.sub.5 are independently(a) hydrogen(b) C.sub.1-8 alkyl(c) C.sub.2-8 alkenyl(d) C.sub.2-8 alkynyl(e) (CH.sub.2).sub.m --C.sub.3-8 cycloalkyl(f) (CH.sub.2).sub.m --C.sub.3-8 cycloalkenyl(g) (CH.sub.2).sub.m -aryl(h) (CH.sub.2).sub.m --CO.sub.2 R.sub.6(i) (CH.sub.2).sub.m --OR.sub.6wherein,R.sub.6 is hydrogen, C.sub.1-4 alkyl or aryl,m is 0-4,or a pharmaceutically acceptable addition salt thereof.