Patent ID: 7335484
Filing Date: 2008-02-26
Classification: A61K,C07K,C12N,Y10S

Abstract:
1. A method of screening drugs for their effect on activity of a retinoid metabolizing protein, comprising exposing a cell that has been transfected with a nucleic acid molecule encoding the protein, or a descendent cell thereof, to a drug, wherein said transfected cell or descendent cell thereof expresses the protein, and determining the effect on the activity, wherein said protein oxidizes a retinoid, said nucleic acid molecule comprising a nucleotide sequence that hybridizes under high stringency conditions, wherein high stringency conditions include a wash step of about 0.2×SSC at 50° C., to a polynucleotide having the nucleotide sequence shown as SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:31.