Patent ID: 6916475
Filing Date: 2005-07-12
Classification: A61K,C07K,Y10S

Abstract:
1. A method of regulating the composition of T cell lymphocytes in HIV+ sera comprising: an anti-idiotypic antibody having specific reactivity with an idiotope common to at least three types of human anti-HIV-antibody of differing specificities, but no significantly reactive with idiotypes of human non-HIV-1 antibodies; and enhancing apoptosis of T cells lymphocytes in HIV+ sera by administering a sufficient amount of an anti-idiotypic monoclonal antibody or binding fragment thereof having specific reactivity with an idiotope specifically bound by monoclonal antibody 1F7 produced by hybridoma ATCC Accession No. HB11286, and which idiotope is common to at least three types of human anti-HIV-antibody of differing specificities, but not significantly reactive with idiotypes of human non-HIV-1 antibodies.