Patent ID: 8093228
Filing Date: 2012-01-10
Classification: A61K,A61P

Abstract:
1. A method of reducing foam formation in a patient's stomach in response to administration of a bisphosphonate, comprising administering to the patient a composition consisting essentially of the bisphosphonate in combination with an antifoaming agent in an amount of from 3% to 40% by weight of the composition, a pharmaceutically acceptable carrier, and one or more of an antacid, a vitamin D derivative, or a calcium supplement, wherein the antifoaming agent is one or more polydimethylsiloxanes, and wherein the pharmaceutically acceptable carrier is selected from the group consisting of one or more of microcrystalline cellulose, lactose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate, calcium carbonate, povidone, sucrose, stearic acid, sodium starch glycollate, talc, maize starch, mannitol, pregelatinized starch, low-substituted hydroxypropyl cellulose, silicon dioxide, sodium stearyl fumarate, gelatin, and crospovidone, effective to reduce foam formation, thereby reducing formation of foam in the patient's stomach.