Patent ID: 6479520
Filing Date: 2002-11-12
Classification: A61K

Abstract:
A method for regulating apoptosis in human cells, comprising exposing said cells to an effective amount of formula: whereinX is O or S; R1 is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-4alkyl, or C1-4alkyl substituted by 1 to 3 fluoro groups; R2 is hydrogen, â€”CN, â€”CONR5R6, â€”CO2R7, 5-tetrazolyl, â€”NO2, â€”NH2 or â€”NHCOR8 wherein R5 to R8 are independently hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydrogen or C1-4alkyl; and R is hydrogen, halo, C1-4alkyl, C1-4alkoxy, cyano, â€”CONR9R10, â€”C2R11, â€”S(O)nC1-4alkyl, â€”NO2, â€”NH2, â€”NHCOR12, or â€”SO2NR13R14 wherein n is 0, 1 or 2 and R9 to R14 are independently hydrogen or C1-4alkyl.