Patent ID: 7786072
Filing Date: 2010-08-31
Classification: A61K,C07K,C12N

Abstract:
1. An alpha-helical peptide, comprising: (a) a first alpha amino acid located at position i, comprising a first alpha carbon; (b) a second alpha amino acid located at position i+4 or i+7 relative to said first alpha amino acid, comprising a second alpha carbon; and (c) an unsubstituted alkane or alkene hydrocarbon chain covalently connecting said first alpha carbon to said second alpha carbon; wherein the length of the hydrocarbon chain is 7 or 8 carbon atoms if the second alpha amino acid is located at position i+4; the length of the hydrocarbon chain is 9 to 12 carbon atoms if the second alpha amino acid is located at position i+7; and the secondary structure of the peptide is alpha-helical.