Patent ID: 6492136
Filing Date: 2002-12-10
Classification: C07H,C07K

Abstract:
A method of synthesis of a material corresponding to the formula:R3â€”Xâ€”H comprising a material corresponding to the following formula: being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile;whereinR1 represents a group selected from the group consisting of â€”NHâ€”COâ€”CH2â€”Ph, â€ƒwherein x represents an integer; and R5 and R6 each represents a non-interfering group; R2 represents an intermediate linked to a solid support selected from the group consisting of: R3 represents an alkyl, a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid, heterocycle or aromatic; X represents O, N(H), N(Râ€³), C(O)O, S, C(O)N(H) or C(O)N(Râ€³), Râ€³ being a non-interfering group; and Support represents a solid support.