Patent ID: 6316632
Filing Date: 2001-11-13
Classification: C07D,Y02P

Abstract:
A process for preparing a compound of formula V or of formula X comprising reacting a compound of the formula ##STR21##in a reaction inert solvent in the presence of a base and a palladium catalyst to obtain a compound of the formula ##STR22##wherein:X is Cl, Br, or I;Z is H, (C.sub.1 -C.sub.4) alkyl, methoxy, tifluoromethoxy, F, or Cl;Ar is (C.sub.6 -C.sub.10) al optionally substituted by from 1 to 3 R.sup.5 groups;R.sup.1 is (C.sub.1 -C.sub.6) straight or branched alkyl, (C.sub.3 -C.sub.7) cycloalkyl, or (C.sub.6 -C.sub.10) aryl, said alkyl, cycloalkyl, and aryl groups beings optionally substituted by from 1 to 3 R.sup.5 groups;R.sup.3 and R.sup.4 are independently selected from H, and (C.sub.1 -C.sub.6) alkyl, wherein when R.sup.3 and R.sup.4 are (C.sub.1 -C.sub.6) alkyl they are optionally linked to each other by a single bond; andeach R.sup.5 is independently selected from halo, cyano, nitro, (C.sub.1 -C.sub.6) halosubstituted alkyl, (C.sub.1 -C.sub.6) alkoxy, (C.sub.6 -C.sub.10)aryloxy, (C.sub.1 -C.sub.6) halosubstituted alkyl, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.6) alkenyl, (C.sub.2 -C.sub.6) alkynyl, (C.sub.1 -C.sub.6) alkylthio, (C.sub.1 -C.sub.6) alkylsulfinyl, (C.sub.1 -C.sub.6) alkylsulfonyl, (C.sub.1 -C.sub.6) alkyl-OC(O)--, (C.sub.1 -C.sub.6) alkyl-OC(O)--(C.sub.1 -C.sub.6) alkyl-, (C.sub.1 -C.sub.6) alkyl-C(O)O--, (C.sub.1 -C.sub.6) alkyl-C(O)--(C.sub.1 -C.sub.6) alkyl(O)--, (C.sub.1 -C.sub.6) alkyl-C(O)--, (C.sub.1 -C.sub.6) alkyl-C(O)--(C.sub.1 -C.sub.6) alkyl-, (C.sub.6 -C.sub.10) aryl-, (C.sub.6 -C.sub.10) aryl-(C.sub.1 -C.sub.6) alkyl-, and (C.sub.3 -C.sub.7) cycloalkyl.