Patent ID: 8119598
Filing Date: 2012-02-21
Classification: A61K,A61L,A61P

Abstract:
1. A method for the reconstruction, repair or cushioning of a joint comprising inserting into the joint, or into a site near the joint, a synthetic polypeptide material comprising crosslinked polypeptides, wherein each polypeptide is between 150 and 500 amino acids in length and comprises (A) at least three consecutive beta-sheet/beta-turn structures consisting of a portion of the amino acid sequence of a protein selected from the group consisting of elastin, lamprin, spider silk protein, and resilin, wherein the amino acid sequence of said three consecutive beta-sheet/beta-turn structures may be modified by the addition, deletion or substitution of from 1 to about 10 amino acid residues relative to the portion of the amino acid sequence of said protein, and (B) at least one crosslinking amino acid residue distinct from and alternating with the at least three consecutive beta-sheet/beta turn structures that participates in cross-linking.