Patent ID: 6015800
Filing Date: 2000-01-18
Classification: C07D

Abstract:
A compound of formula ##STR57## or a pharmaceutically acceptable salt thereof wherein * is R, S, or RS(.+-.);R is a secondary or tertiary amine of the formula ##STR58## wherein R.sub.11 and R.sub.12 are each independently, hydrogen,methyl,ethyl,propyl,butyl, orcyclohexyl;amino acid deserve of the formula ##STR59## n is an integer of from 1 to 4; R.sub.1 is hydrogen,alkyl,carboxyalkyl,phosphoroalkyl, orphosphonoalkyl;R.sub.2 is hydrogen,hydroxy, oramino;R.sub.3 and R.sub.4 are each independentlyhydrogen,alkyl,cycloalkyl of from 5 to 8 atoms,halogen,haloalkyl,nitro,cyano,SO.sub.2 CF.sub.3,C(O)R.sub.6,(CH.sub.2).sub.m SO.sub.2 R.sub.6,(CH.sub.2).sub.m CO.sub.2 R.sub.9 wherein R.sub.9 is hydrogen, alkyl, aralkyl, or cycloalkyl,(CH.sub.2).sub.m CONR.sub.7 R.sub.8,(CH.sub.2).sub.m SO.sub.2 NR.sub.7 R.sub.8, orNHCOR.sub.6 wherein m is an integer of from 0 to 4, R.sub.6 is hydroxy, ##STR60## alkyl, haloalkyl, aryl, or aralkyl, and R.sub.7 and R.sub.8 are each independently hydrogen, alkyl, aralkyl, or aryl;R.sub.5 is hydrogen,alkyl,alkynyl,halogen,haloalkyl,aryl,aralkyl,heteroaryl,nitro,cyano,SO.sub.2 CF.sub.3,C(O)R.sub.6,(CH.sub.2).sub.m CO.sub.2 R.sub.9,(CH.sub.2).sub.m CONR.sub.7 R.sub.8,(CH.sub.2).sub.m SO.sub.2 R.sub.6,(CH.sub.2).sub.m SO.sub.2 NR.sub.7 R.sub.8 orNHCOR.sub.6 wherein m, R.sub.7, and R.sub.8 are as defined above;Z is the side-chain of an amino acid selected from --CH.sub.3, --CH.sub.2 OH, --CH.sub.2 CO.sub.2 H, --CH.sub.2 SH and ##STR61## R.sub.5 and the --(CH.sub.2).sub.n --R side chain may be at the a or b position on the ring.