Patent ID: 6274572
Filing Date: 2001-08-14
Classification: A61P,C07J

Abstract:
A compound selected from the group consisting of a compound of formula ##STR5##wherein R.sub.1 is selected from the group consisting of halogen, --OH, alkoxy of 1 to 8 carbon atoms and acyloxy group containing 1 to 12 carbon atoms and R.sub.2 is hydrogen or halogen or R.sub.1 and R.sub.2 together form a second bond, Z is selected from the group consisting of unsubstituted or substituted alkylthio of 1 to 8 carbon atoms, unsubstituted or substituted carbocyclic aryl of 6 to 12 carbon atoms, halogen, --CH, --SH, thiocyanato, --COOA and --CH.sub.2 COOA, the said substituents being at least one member of the group consisting of halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, --NH.sub.2, mono and dialkyl amino of 1 to 4 carbon atoms, --OH, acyloxy, --CN, --CF.sub.3, phenyl and --OCO--(CH.sub.2).sub.n --COOH, n is an integer from 2 to 5, A is hydrogen or alkyl of 1 to 8 carbon atoms, Y is hydrogen or methyl, the dotted lines indicate an optional double bond and their addition salts with non-toxic, pharmaceutically acceptable acids and bases, with the provisos that when R.sub.1 and R.sub.2 form a double bond, Z is not halogen and the compound is not 9.alpha.-fluoro-16.alpha.-methyl-21-chloro-.DELTA..sup.1,4 -pregnadiene-11.beta.-ol-3,20-dione.