Patent ID: 7550608
Filing Date: 2009-06-23
Classification: A61P,C07D,Y02P

Abstract:
1. A process for the preparation of docetaxel, the process comprising: (a) protecting the C(7) and the C(10) hydroxy groups of 10-deacetylbaccatin III (10-DAB) with a bridging silicon-based protecting group to form 10-DAB derivative (12); (b) treating 10-DAB derivative (12) with a β-lactam side chain precursor to form 10-DAB derivative (13); and (c) deprotecting 10-DAB derivative (13) to form docetaxel; wherein 10-DAB derivative (12) and 10-DAB derivative (13) correspond to Formulae (12) and (13), respectively: the bridging silicon-based protecting group corresponds to Formula (2): the β-lactam side chain precursor corresponds to Formula (3): L X Z is —CH