Patent ID: 6939878
Filing Date: 2005-09-06
Classification: A61L,A61P,C07D

Abstract:
1. A method for the treatment of a disease selected from the group consisting of transplantation rejection, host v. graft disease, graft v. host disease, leukemia/lymphoma, hyperproliferative vascular disorder, multiple sclerosis, rheumatoid arthritis, inflammatory disease, and fungal infection, comprising administering to an animal in need thereof an effective amount of a glycosylated deuterorapamycin or a pharmaceutically acceptable salt thereof, wherein the glycosylated deuterorapamycin is glycosylated at position 42 of a deuterorapamycin selected from the group consisting of 7-deuteromethyl rapamycin, epi-7-deuterornethyl rapamycin, 31d-rapamycin, 7,43-d 6 -rapamycin, 31,42-d 2 -rapamycin, and isomers thereof.