Patent ID: 8513220
Filing Date: 2013-08-20
Classification: A61P,C07F

Abstract:
1. A method of treating an immunosuppressant disorder associated with the sphingosine-1-phosphate receptor inhibition, wherein the disorder is selected from rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune uveitis, dry eye, or multiple sclerosis, in a mammal in need thereof, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound represented by Formula I or a pharmaceutically acceptable salt thereof: wherein: R R R R X is CR Y is CR Z is CR A is O, CH L R R R R R R Q is C a is 0, 1, 2, 3 or 4; in combination with at least one additional component selected from the group consisting of one or more emulsifying agent, wetting agent, sweetening agent, flavoring agent, tonicity adjuster, preservative, buffer, anti-oxidant and combinations thereof.