Patent ID: 9095126
Filing Date: 2015-08-04
Classification: A01K,A61K,A61P,C07K,C12N

Abstract:
1. A method of enhancing macrophage Aβ phagocytosis activity of a peripheral macrophage of a mammal with Alzheimer's disease, the method comprising contacting the peripheral macrophage of the mammal with Alzheimer's disease with an inhibitor of a component of TGF-β signaling pathway and with an activator of a component of bone morphogenic protein-Smad1/5/8-PAK2 signaling pathway, wherein the inhibitor of a component of TGF-β signaling pathway is at least one selected from the group consisting of dominant negative TGF-β receptor, a nucleic acid encoding a dominant negative TGF-β receptor, SB-505124 and SB-431542, and wherein the activator of a component of bone morphogenic protein-Smad1/5/8-PAK2 signaling pathway is at least one selected from the group consisting of BMP-2, BMP-4, a nucleic acid encoding BMP-2, and a nucleic acid encoding BMP-4, thereby inducing the peripheral macrophage to infiltrate the central nervous system (CNS) of the mammal.