Patent ID: 7875602
Filing Date: 2011-01-25
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula (II) or a pharmaceutically acceptable salt thereof, wherein X is a covalent bond; Y is ═NO—, —N(H)O—, ═N— or S; T is independently CRR′; each of R and R′ is independently selected from hydrogen, C1-4 alkyl, and substituted C1-4 alkyl; n is an integer from 0 to 8; R R R R R R wherein substituted C1-4 alkyl is an alkyl group having 1 to 4 carbons and one to five substituents independently selected from the group consisting of halo, lower alkoxy, hydroxy, cyano, nitro, phenyl, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, and lower alkylcarbonylamino; substituted lower alkyl is an alkyl group having 1 to 6 carbons and one to five substituents independently selected from the group consisting of halo, lower alkoxy, hydroxy, cyano, nitro, phenyl, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, and lower alkylcarbonylamino; substituted lower alkyl aminomethyl is a monovalent radical having the formula —CH optionally substituted lower alkylcarbonyloxy methyl is a monovalent —CH substituted vinyl is —CH═CH optionally substituted phenyl is phenyl optionally substituted with one to five substituents independently selected from the group consisting of halo, lower alkyl, lower alkoxy, hydroxy, cyano, nitro, amino, halogenated lower alkyl, halogenated lower alkoxy, carbonyl, hydroxycarbonyl, lower alkylcarbonyloxy, benzyloxy, optionally substituted piperidino, lower alkoxycarbonyl, and lower alkylcarbonylamino; optionally substituted carbocyclic is carbocyclic optionally substituted with one to five substituents independently selected from the group consisting of halo, lower alkyl, lower alkoxy, hydroxy, cyano, nitro, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, lower alkylcarbonylamino, sugar and phosphosugar, optionally substituted heterocyclic, is heterocyclic optionally substituted with one or two substituents independently selected from the group consisting of halo, lower alkyl, lower alkoxy, hydroxy, cyano, nitro, phenyl, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, lower alkylcarbonylamino, sugar and phosphosugar; optionally substituted piperidino is piperidino optionally substituted with one or two substituents independently selected from the group consisting of halo, lower alkyl, lower alkoxy, hydroxy, cyano, nitro, phenyl, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, lower alkylcarbonylamino, sugar and phosphosugar; and optionally substituted fused 2-, 3- or 4-ring heterocyclic is fused 2-, 3- or 4-ring heterocyclic optionally substituted with one or five substituents independently selected from the group consisting of halo, lower alkyl, lower alkoxy, hydroxy, cyano, nitro, phenyl, amino, halogenated lower alkyl, halogenated lower alkoxy, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyloxy, lower alkylcarbonylamino, sugar and phosphosugar.