Patent ID: 8182791
Filing Date: 2012-05-22
Classification: A61K,A61P

Abstract:
1. A formulation for use in an inhaler device, comprising: carrier particles in the form of an agglomerate consisting of a plurality of crystals fused to one another via solid bridges such that the particles have no tendency to disintegrate on expulsion from the inhaler device, wherein the carrier particles have a diameter of at least 50 μm and a mass median diameter of at least 175 μm and a fissured surface, wherein the fissures are at least 20 μm wide and at least 20 μm deep; pharmaceutically active particles; and composite particles comprising additive material and fine excipient material consisting of one or more crystalline sugars, prepared as a pre-blend prior to the addition of the active and carrier particles by milling or high-energy mixing the additive and fine excipient material; wherein the additive material includes one or more compounds selected from amino acids and derivatives thereof; peptides and polypeptides having a molecular weight from 0.25 to 1000 Kda, and derivatives thereof; phospholipids or a derivative thereof; fatty acids and derivatives thereof; or a surface active material.