Patent ID: 6339101
Filing Date: 2002-01-15
Classification: A61K,A61P

Abstract:
A method for treating a nerve-related vision disorder, improving vision, treating memory impairment or enhancing memory performance in an animal, which comprises administering to said animal an effective amount of a N-linked sulfonamide of an N-heterocyclic carboxylic acid compound or isostere thereof, wherein the compound has an affinity for an FKBP-type immunophilin, wherein the FKBP-type immunophilin is FKBP-12, wherein the nerve-related vision disorder is selected from the group consisting of visual impairments; orbital disorders; disorders of the lacrimal apparatus; disorders of the eyelids; disorders of the conjunctiva; disorders of the cornea; cataract; disorders of the uveal tract; disorders of the retina; disorders of the optic nerve or visual pathways; free radical induced eye disorders and diseases; immunologically-mediated eye disorders and diseases; eye injuries; and symptoms and complications of eye disease, eye disorder, and eye injury, wherein the compound is of formula (I): wheren is 1-3; R1 is selected from the group consisting of hydrogen, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, aryl, heteroaryl, carbocycle, or heterocycle; D is a bond, or a C1-C10 straight or branched chain alkyl, C2-C10 alkenyl or C2-C10 alkynyl; R2 is a carboxylic acid or a carboxylic acid isostere; wherein said alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocycle, heterocycle, or carboxylic acid isostere is optionally substituted with one or more substituents selected from R3, where R3 is hydrogen, hydroxy, halo, haloalkyl, thiocarbonyl, alkoxy, alkenoxy, alkylaryloxy, aryloxy, arylalkyloxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, alkylthio, sulfonyl, C1-C6 straight or branched chain alkyl, C2-C6 straight or branched chain alkenyl or alkynyl, aryl, heteroaryl, carbocycle, heterocycle, or CO2R4 where R4 is hydrogen or C1-C9 straight or branched chain alkyl or alkenyl; or a pharmaceutically acceptable salt, ester or solvate thereof.