Patent ID: 8357686
Filing Date: 2013-01-22
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein: A, B, D, and G are, independently of one another, N or C(R3); wherein R3 is H, F, Cl, Br, I, OH, CF R4, R5, R6, R7, R8, R10 are, independently of one another, H or (C or, alternatively, R4 and R5, R6 and R7, independently of one another, taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C R9, R11, and R12 are, independently of one another, H, (C R13 and R14 are, independently of one another, H or (C R15 is H, (C x is 0, 1, 2, 3, 4, 5 or 6; R1 is H, (C X is N(R16), O, a bond, (R17)C═C(R18), C≡C, or a group of the formula (CR19R20) Y is O, S, N(R21), or C═O; R16, R17, and R18 are, independently of one another, H or (C R19 and R20 are, independently of one another, H or (C y is 1, 2, 3, 4, 5 or 6; R21 is H or (C E is a 3-14 membered bivalent carbo- or heterocyclic ring structure having 0-4 heteroatoms selected from the group consisting of N, O and S, which ring structure may optionally have substituents selected from the group consisting of H, F, Cl, Br, I, OH, CF R22, R23, R24, R25, R26, and R28 are, independently of one another, H, (C or, alternatively, R22 and R23, R24 and R25, independently of one another, taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C R27, R29 and R30 are, independently of one another, H, (C K is a bond, C≡C, (R31)C═C(R32), or a group of the formula (CR33R34) R31 and R32 are, independently of one another, H or (C Z is O, S, N(R40), CO, SO, or SO R33 and R34 are, independently of one another, H, (C z is 1, 2, 3, 4, 5 or 6; R40 is H or (C R2 is H, (C R41, R42, R43, R44, R45, R46, and R47 are, independently of one another, H or (C or, alternatively, R42 and R43, R46 and R47, independently of one another, taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C E, K and R2 together form a tricyclic system wherein the rings may be, independently of one another, saturated, partially saturated or unsaturated and, in each case, comprise 3- 8 ring atoms; L is O; Q is: R91 is H, (C R92 is H or (C R93 and R94 are, independently of one another, H, (C o′ and p′ are, independently of one another, 0, 1, 2, 3, 4, 5 or 6; R95 and R96 are, independently of one another, OH, O—(C R97, R98, R99, R100, R103, and R104 are, independently of one another, H or (C or, alternatively, R97 and R98 taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C R101 and R102 are, independently of one another, H, (C R105, R106, R107, R109, R110, R112, R113, R114, R115, R116, R117, R118, and R119 are, independently of one another, H or (C or, alternatively, R117 and R118 taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C q′ and r′ are, independently of one another, 0, 1, 2, 3, 4, 5 or 6; R108 is selected from the group consisting of H, (C R111 is selected from the group consisting of OH, O—(C R120, R121, R122, R123, R124, R125, R126, and R127 are, independently of one another, H or (C or, alternatively, R120 and R121, R124 and R125, independently of one another, taken together with the nitrogen atom to which they are attached form a 5-6 membered ring which optionally may contain an additional heteroatom selected from the group consisting of NH, N—(C or an N-oxide thereof or a physiologically tolerated salt thereof.