Patent ID: 8234080
Filing Date: 2012-07-31
Classification: A61P,C12Q,G01N

Abstract:
1. A method for identifying a compound which modulates the activity of telomerase comprising (a) using a computer program to generate a three-dimensional structure of the Fingers-Palm pocket of a telomerase protein of SEQ ID NO:9 in complex with an RNA template and complementary telomeric DNA, wherein said Fingers-Palm pocket consists of amino acid residues 170, 193, 195, 254, 302, 304, 307 and 308 of SEQ ID NO:9 and said three-dimensional structure has a space group of P2 (b) designing or screening for a compound that binds to said pocket; and (c) testing the compound designed or screened for in (b) by in vitro or in vivo assay for its ability to modulate the activity of telomerase, thereby identifying a compound that modulates the activity of telomerase.