Patent ID: 6103884
Filing Date: 2000-08-15
Classification: C07H

Abstract:
A method of synthesizing a glycosylated analog of fusidic acid comprising the steps:a) providing in any order:i) an unmodified fusidic acid, wherein said fusidic acid has an acetate group at the C-16 position,ii) a derivatizing reagent selected from the group consisting of carbohydrate glycals and activated carbohydrate glycals, wherein said carbohydrate glycals and said activated carbohydrates glycal are olefins, andiii) a catalyst;b) reacting said unmodified fusidic acid, said derivatizing agent, and said catalyst under conditions such that a glycosylated analog of fusidic acid is formed; andc) hydrolyzing said glycosylated analog of fusidic acid under conditions such that said acetate group at said C-16 position is not hydrolyzed.