Patent ID: 7879863
Filing Date: 2011-02-01
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound represented by the formula (A): wherein X is a carbon atom; M is selected from the group consisting of a hydrogen atom, a halogeno group, a lower alkyl group optionally having substituent(s), —(CH wherein m is an integer of 0 to 2, and Ra and Ra′ are each independently selected from the group consisting of a hydrogen atom and a lower alkyl group; Z is selected from the group consisting of a single bond, —CH(Rb)—, —CH(Rb)—CH(Rb′)—, —CH═CH—, and —C(O)— wherein Rb and Rb′ are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a nitro group, a cyano group, an ammonium group, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and -QR10 wherein Q is selected from the group consisting of —O—, —S(O) wherein p is an integer of 0 to 2, and R10 and R11 are each independently selected from the group consisting of a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and an acyl group, or R10 and R11 are optionally bonded to form a ring; B is selected from the group consisting of a hydrogen atom, a lower alkyl group optionally having substituent(s), and a group represented by the formula (D): wherein ring b is selected from the group consisting of a cycloalkyl group, a heterocyclic group, and an aryl group, and R4 and R5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a cyano group, a nitro group, an ammonium group, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and -Q′R20 wherein Q′ is selected from the group consisting of —O—, —S(O) wherein p′ is an integer of 0 to 2, and R20 and R21 are each independently selected from the group consisting of a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), an acyl group, and a hydroxyl group, or R20 and R21 are optionally bonded to form a ring; R3 is selected from the group consisting of a hydrogen atom, a lower alkyl group optionally having substituent(s) and an aryl group optionally having substituent(s), or R3 is optionally bonded to B to form a nitrogen-containing 5- or 6-membered ring, wherein said nitrogen-containing 5- or 6- membered ring optionally further contains a heteroatom in the ring in addition to the nitrogen atom, and wherein said nitrogen-containing 5- or 6-membered ring is optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, an alkylamino group, an acyl group, a heterocyclic group optionally having substituent(s), and an aryl group optionally having substituent(s); Y is —C(O)— or —SO R R2 is a hydrogen atom or a lower alkyl group, or R n is 0 or 1; and R6 and R or a pharmaceutically acceptable salt thereof.