Patent ID: 7902200
Filing Date: 2011-03-08
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I), or a salt thereof: wherein: R HET-1 is a 5- or 6-membered, C-linked heteroaryl ring containing a nitrogen atom in the 2-position relative to the amide nitrogen to which the ring is attached and optionally 1 or 2 further ring heteroatoms independently selected from 0, N, and S; which ring is optionally substituted on any nitrogen atom provided it is not thereby quaternised, by a substituent selected from R Ring A is selected from phenyl, HET-2, and HET-3; wherein when Ring A is phenyl it is substituted with R R R R HET-5 is a 4-, 5-, or 6-membered, C- or N-linked heterocyclyl ring containing 1, 2, 3, or 4 heteroatoms independently selected from O, N, and S, wherein a —CH R R R R R R R HET-2 is a 5- or 6- membered heteroaryl ring, containing 1, 2, or 3 ring hetereoatoms independently selected from O, S, and N; which ring is substituted on an available carbon atom by a substituent selected from R R HET-3 is a fused bicyclic ring system of formula —B—C; wherein B is a Ring is directly attached to the linking oxygen atom and Ring B is phenyl or is a 5- or 6-membered heteroaryl ring containing 1, 2, or 3 heteroatoms independently selected from O, N, and S provided there are no O—O, S—S or O—S bonds in the ring; wherein Ring B is optionally substituted on any nitrogen atom by a substituent selected from R R R HET-4 is a 5- or 6-membered, C- or N- linked unsubstituted heteroaryl ring containing 1, 2, or 3 ring heteroatoms independently selected from O, N, and S; Ring C is a 5- to 7-membered heterocyclic ring fused to Ring B, containing 1, 2, or 3 ring hetereoatoms independently selected from O, S and N provided that there are no O—O, S—O or S—S bonds within the ring, wherein any ring carbon or sulfur atom may optionally be oxidised and wherein Ring C is optionally substituted on any nitrogen atom by a substituent selected from R R R R p is independently at each occurrence 0, 1, or 2.