Patent ID: 6548302
Filing Date: 2003-04-15
Classification: A61K,C08J,C12N,Y10S

Abstract:
A composition for delivery of a nucleic acid, comprising: a nucleic acid formulated in a biocompatible polymer having recurring monomeric elements in said polymer represented in general formula (XV): wherein, independently for each occurrence:Q1 represents O or S; Q2 represents O, S or NRâ€²; X represents O, S or NRâ€²; n is an integer of about five or more; Râ€² represents H or alkyl; R represents an organic or organometallic moiety; R1 represents hydrogen, alkyl, â€”O-alkyl, â€”O-cycloalkyl, aryl, â€”O-aryl, heterocycle, â€”O-heterocycle, â€”Sâ€”R4, â€”Oâ€”(C&boxH;O)â€”R4, â€”Cl or â€”N(R2)R3; R2 and R3, each independently, represent a hydrogen, an alkyl, an alkenyl, â€”(CH2)n-R4, or R2 and R3 taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure; and R4 represents a hydrogen, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle.