Patent ID: 8361977
Filing Date: 2013-01-29
Classification: A61K,C07H,C12N

Abstract:
1. An antisense oligonucleotide having a nucleotide sequence at least 90% complementary to a target region of SEQ ID NO: 1 as measured over the entirety of the antisense oligonucleotide, wherein: the 5′-most nucleotide of the target region is nucleotide 121, 122, 123, 124, 125, 126, 127, 128 or 129 of SEQ ID NO: 1; the antisense oligonucleotide is 12 to 20 nucleotides in length; and each nucleoside of the antisense oligonucleotide comprises a 2′-O-methoxyethyl sugar modification.