Patent ID: 6303134
Filing Date: 2001-10-16
Classification: A61K

Abstract:
A method for selectively inhibiting release of a predetermined endogenous compound comprising the steps of:selecting an in situ locus in the central nervous system which includes agonist receptors and heterologous receptors that are coupled to common G-proteins; andstereotaxically delivering to the in situ locus in the central nervous system at least one biodegradeable, non-spherical polymeric microstructure comprising an agonist and a pharmaceutically acceptable carrier wherein the microstructure has a size and shape sufficient to precent dispersion from the locus, and wherein the microstructure provides sustained release of the agonist via surface erosion to effectively downregulate G-proteins common to the agonist receptor and the heterologous receptor to desensitize the heterologous receptor in order to inhibit release of the predetermined endogenous compound released by the heterologous receptor.