Patent ID: 6727282
Filing Date: 2004-04-27
Classification: C07C

Abstract:
A compound represented by the formula: or a pharmaceutically acceptable salt or ester thereof, wherein:x represents 0, 1 or 2; t represents either 0 or 1; Xâ€² represents â€”N(R34)â€” or â€”Oâ€”; or R33â€”Xâ€²â€” represents cycloalkyl or aryl radicals; Y and Y â€² each independently represents O or S; R1, R30, R31 and R32 each independently represent hydrogen, â€”OH, â€”(CH2)C(O)CH2, â€”CH2SO2NH2, â€”CO2CH3, â€”CONHCH3, â€”CON(CH3)2, â€”CH2C(O)NHCH3, â€”CH2C(O)N(CH3) 2, â€”CONH2, â€”C(CH3)2(SH)3â€”C(CH3)7(SCH1), â€”C(CH3)2(S(O)CH3), â€”C(CH3)2(S(O)3CH3), alkyl, haloakyl, alkenyl, alkynyl, aralkyl or cycloakyl radicals or the side chain of the amino acid asparagine, S-methyl cysteine or the corresponding sulfoxide or sulfoxide derivatives thereof, leucine, isoleucine, allo-isoleucine, tert-leucine, phenylalanine, omithine, alanine, norleucine, glutamine, valine, threonine, serine, o-alkyl serine, aspartic acid, beta-cyno alanine or allothreonine; or R30 and R32 together with the carbon atoms to which they are attached form a cycloalkyl radical; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalky or aralkyl radicals, which radicals are optionally substituted with halogen, alkyl, â€”NO2, â€”CN, â€”CF3, â€”OR9 or â€”SR9 radicals, wherein R9 represents hydrogen or alkyl radicals; R3, R33, and R34 each independently represent hydrogen, alkyl, haloakyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or aminoalkyl radicals or N-mono- or N,N-disubstituted aminoalkyl radicals, wherein said substituents are alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl radicals; R4 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, hetercycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl, or aryl or aralkyl radicals substituted with one or more substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, nitro, cyano, and haloalkyl; R4 represents hydrogen or alkyl radicals; and wherein alkyl, alone or in combination, means a straight-chain or branched-chain alkyl radical containing from 1 to 8 carbon atoms; alkenyl, alone or in combination. means a straight-chain or branched-chain hydrocarborn radial having one or more double bonds and containing from 2 to 8 carbon atoms; alkynyl, alone or in combinaticm, means a straight-chain hydrocarbon radical having one or more triple bonds and containing from 2 to 10 carbon atoms; cycloalkyl, alone or in combination, means a saturated or partially saturated monocyclic, bicyclic or tricyclic alkyl radical wherein each cyclic moiety contains from 3 to 8 carbon atoms; and aryl, alone or in combination, means a phenyl or napbthyl radical which is optionally substituted with one or more alkyl, alkoxy, halogen, hydroxy, amino, acetylamino, nitro, cyano or haloalkyl radicals.