Patent ID: 6133290
Filing Date: 2000-10-17
Classification: C07D

Abstract:
A compound of formula I: ##STR8## or a pharmaceutical acid addition salt thereof; where: A--D is CH--CH.sub.2 or C.dbd.CH;R is NR.sup.3 C(O)R.sup.4, NR.sup.3 SO.sub.2 R.sup.5, NHC(O)NR.sup.6 R.sup.7, NHC(S)NR.sup.6 R.sup.7, or NHCO.sub.2 R.sup.8 ;R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.2 is hydrogen or R.sup.1 and R.sup.2 combine, together with the 6 membered ring to which they are attached, to form a 6:5, 6:6, or 6:7 fused bicyclic ring;R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.4 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl; C.sub.3 -C.sub.6 cycloalkyl; phenyl(C.sub.1 -C.sub.4 alkylene); C.sub.1 -C.sub.4 alkyl .omega.-substituted with phenoxy; C.sub.1 -C.sub.4 alkyl .omega.-substituted with C.sub.1 -C.sub.4 alkoxy; phenyl monosubstituted with halo; phenyl monosubstituted with C.sub.1 -C.sub.4 alkoxy; phenyl monosubstituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkylthio, or C.sub.1 -C.sub.4 acyl; phenyl disubstituted with substitutents selected from halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and nitro; heterocycle; furyl optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, or halo; thienyl optionally substituted with halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or pyridinyl optionally substituted with halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;R.sup.5 is C.sub.1 -C.sub.6 alkyl, phenyl, substituted phenyl, or (C.sub.1 -C.sub.6 alkyl).sub.2 amino;R.sup.6 and R.sup.7 are independently C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.4 alkyl), or substituted phenyl(C.sub.1 -C.sub.4 alkyl), or R.sup.6 and R.sup.7 combine, together with the nitrogen atom to which they are attached, to form a pyrrolidine, piperidine, piperazine, 4-substituted piperazine, morpholine or thiomorpholine ring;R.sup.8 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, phenyl, substituted phenyl, or C.sub.3 -C.sub.8 cycloalkyl.