Patent ID: 6369236
Filing Date: 2002-04-09
Classification: A61P,C07D

Abstract:
A compound of the formula I in which the symbols have the following meaning:R(1) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or â€”CaH2a-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(8)R(9); R(8) and R(9) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; a is zero, 1 or 2; or R(1) is â€”CbH2b-heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(10)R(11); R(10) and R(11) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; b is zero, 1 or 2; or R(1) is â€”CdH2d-cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms; d is zero, 1 or 2; R(2) and R(3) independently of one another are hydrogen, F, Cl, Br, I, CF3, â€”CN, â€”NO2, CH2OR(17), COâ€”R(6), Oâ€”R(7), O-(alkylene having 2, 3 or 4 carbon atoms)-Oâ€”R(17) or NR(50)R(51); R(17) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(6) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, OR(30) or phenyl which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(31)R(32); R(31) and R(32) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(30) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(50) and R(51) independently of one another are -(alkylene having 2, 3 or 4 carbon atoms)-Oâ€”R(52); R(52) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7, or 8 carbon atoms; R(7) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(12)R(13); R(12) and R(13) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; or R(7) is heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(14)R(15); R(14) and R(15) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; or R(2) and R(3) independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or â€”CgH2g-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(18)R(19); R(18) and R(19) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; g is zero, 1 or 2; or R(2) and R(3) independently of one another are â€”ClH2l-heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(20)R(21); R(20) and R(21) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; I is zero, 1 or 2; or R(2) and R(3) independently of one another are SOnâ€”R(22); n is zero, 1 or 2; R(22) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms or â€”CsC2s-phenyl which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(34)R(35); R(34) and R(35) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; s is zero, 1 or 2; R(4) and R(5) independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, I, CF3, â€”CN, â€”NO2, SOpâ€”R(16), COâ€”R(23), Oâ€”R(24) or O-(alkylene having 2, 3 or 4 carbon atoms)-Oâ€”R(33); p is zero, 1 or 2; R(16) is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(26)R(27); R(26) and R(27) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(23) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or OR(25); R(25) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(24) is hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or phenyl, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals representing F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR(28)R(29); R(28) and R(29) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(33) is hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; or a physiologically tolerable salt thereof;with the proviso that at least one of the radicals R(2) or R(3) is O-(alkylene having 2, 3 or 4 carbon atoms)-Oâ€”R(17) or NR(50)R(51).