Patent ID: 6054604
Filing Date: 2000-04-25
Classification: C07D

Abstract:
A process for preparing a 3-amino-2,2-dimethyl-4-phenyl ester derivative of the formula (4) ##STR13## wherein R.sub.2 denotes hydrogen C.sub.1 -C.sub.6 -alkyl, halogen, C.sub.1 -C.sub.8 alkoxy, a benzoyl group bound via an oxygen or an alkylcarboxyl group having a straight chained or branched C.sub.1 -C.sub.6 -lower alkyl group--wherein the alkyl group may optionally be substituted by one or more halogen atoms which may be identical or different;andR.sub.3 denotes C.sub.1 -C.sub.8 -alkyl or benzyl;in which process:a benzylcyanide derivative of the formula (2) ##STR14## wherein R.sub.2 is defined as before is reacted under the conditions of a Reformatsky reaction in a solvent which is inert under the reaction condition chosen, with a bromoisobutyrate derivative of the formula 3 ##STR15## wherein R.sub.3 is defined as herein before.