Patent ID: 7144720
Filing Date: 2006-12-05
Classification: A61K,C07K,C12N,G01N

Abstract:
1. An isolated DNA comprising a base sequence selected from the group consisting of: (a) a base sequence encoding amino acid residues 1 to 775 of SEQ ID NO:15; (b) a base sequence encoding the amino acid sequence of the ADAM polypeptide encoded by the cDNA contained in NIBH Accession No. FERM BP-6474; (c) a base sequence encoding a partial peptide of amino acid residues 1 to 775 of SEQ ID NO:15 wherein said partial peptide has proteoglycan degrading activity; (d) a first base sequence 95% or more identical to a second base sequence, wherein said second base sequence is (a) or (b), and wherein said first base sequence has proteoglycan degrading activity; and (e) a base sequence comprising a base sequence which hybridizes under stringent conditions to the base sequence of (a), (b), (c), or (d).