Patent ID: 8466171
Filing Date: 2013-06-18
Classification: A61P,C07D

Abstract:
1. A compound which is: rac-4-((1R,2R,6R,7S)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7S)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2S,6S,7R)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2R,6R,7S)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2S,6S,7R)-2-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2R,6R,7S)-2-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7R)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7S)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7S,8S,10S)-3,3-dioxido-9,11-dioxa-3-thia-4-azatetracyclo[5.3.1.0 4-((1R,2S,6S,7R,8R,10R)-3,3-dioxido-9,11-dioxa-3-thia-4-azatetracyclo[5.3.1.0 rac-4-((1R,2R,6R,7S,9R)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7R,8S)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7R,8R)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7R,9S)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7R,9R)-9-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7S,9R)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7S,9S)-9-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-1,7-dimethyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1S,2S,6R,7R)-1,7-dimethyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-1,7-dimethyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-7-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1S,2R,6S,7R)-7-methyl-3,3-dioxido-5-oxo-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-7-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-7-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-1-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1S,2S,6R,7R)-7-methyl-3,3-dioxido-5-oxo-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-7-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S)-1-methyl-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7R,8S)-8-azido-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S,9R)-9-azido-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7R,8S)-8-amino-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2R,6R,7S,9R)-9-amino-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl rac-((1R,2R,6R,7R,8S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl rac-((1R,2R,6R,7S,9R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 benzyl (1S,2S,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-10-oxa-3-thia-4-azatricyclo[5.2.1.0 (1S,2S,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-10-oxa-3-thia-4-azatricyclo[5.2.1.0 (1S,2S,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-N-methyl-10-oxa-3-thia-4-azatricyclo[5.2.1.0 benzyl (1R,2R,6R,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-10-oxa-3-thia-4-azatricyclo[5.2.1.0 (1R,2R,6R,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-N-methyl-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-(1R,2S,6S,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-N-methyl-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7R,8S)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7S,9R)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7R,8R)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7S,9S)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7R,8R)-8-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7S,9S)-9-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7S,8S)-8-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7R,8R)-8-fluoro-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7S,8S)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7R,8R)-8-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1S,2R,6R,7R,9R)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 4-((1R,2S,6S,7S,9S)-9-hydroxy-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7R,8R)-8-azido-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-4-((1R,2S,6S,7S,9S)-9-azido-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl((1S,2R,6R,7S,8S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl((1R,2S,6S,7R,8R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl((1S,2R,6R,7R,9R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 methyl((1R,2S,6S,7S,9S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dioxido-10-oxa-3-thia-4-azatricyclo[5.2.1.0 rac-benzyl (1S,2S,6R,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3-thia-4,8-diazatricyclo[5.2.2.0 rac-benzyl (1S,2S,6S,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-5-oxo-3-thia-4,8-diazatricyclo[5.2.2.0 rac-benzyl rac-(1R,2R,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3-thia-4,8-diazatricyclo[5.2.2.0 rac-4-((1R,2R,6S,7R)-3,3-dioxido-3-thia-4,8-diazatricyclo[5.2.2.0 rac-4-((1R,2R,6S,7R)-8-acetyl-3,3-dioxido-3-thia-4,8-diazatricyclo[5.2.2.0 rac-4-((1R,2R,6S,7R)-8-(ethylsulfonyl)-3,3-dioxido-3-thia-4,8-diazatricyclo[5.2.2.0 methyl rac-(1R,2R,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3-thia-4,8-diazatricyclo[5.2.2.0 phenyl rac-(1R,2R,6S,7R)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3-thia-4,8-diazatricyclo[5.2.2.0 pharmaceutically-acceptable salt or stereoisomer thereof.