Patent ID: 8048986
Filing Date: 2011-11-01
Classification: C07K,C12N

Abstract:
1. A receptor complex comprising: a recombinant receptor polypeptide comprising an extracellular ligand-binding domain derived from a receptor, and a cytoplasmic domain comprising (a) a receptor-derived cytoplasmic domain comprising a JAK-binding site and at least one activation site that is a tyrosine residue and (b) a first interacting polypeptide, heterologous to the receptor-derived cytoplasmic domain, and a recombinant polypeptide comprising a second interacting polypeptide, interacting with the first interacting polypeptide, and an inhibitor of the activation site of the cytoplasmic domain of the recombinant receptor, wherein the inhibitor is selected from the group consisting of a member of the SOCS family, a JAK-phosphatase, and a STAT-phosphatase, wherein the receptor complex is activated by binding of a ligand to the ligand-binding domain and by disruption of the interaction between the first interacting polypeptide and the second interacting polypeptide.