Patent ID: 6306429
Filing Date: 2001-10-23
Classification: A61K,A61P,B63B

Abstract:
A throat drop for the relief of cough and cold symptoms comprising:a) a cooling composition having from about 0.001% to about 10% by weight, a physiological cooling agent selected from the group consisting of menthol, peppermint oil, N-substituted-p-menthane-3-carboxamides, acyclic tertiary and secondary carboxamides, 3-1-menthoxy propan-1,2-diol, and mixtures thereof, andb) a warming composition having from about 0.001% to about 10% by weight, a physiological warming agent selected from the group consisting of vanillyl alcohol n-butyl ether, vanillyl alcohol n-propyl ether, vanillyl alcohol isopropyl ether, vanillyl alcohol isobutyl ether, vanillyl alcohol n-amino ether, vanillyl alcohol isoamyl ether, vanillyl alcohol n-hexyl ether, vanillyl alcohol methyl ether, vanillyl alcohol ethyl ether, gingerol, shogaol, paradol, zingerone, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, ethanol, isopropyl alcohol, iso-amylalcohol, benzyl alcohol, chloroform, eugenol, phosphate derivatives thereof, the commercially available warming agent David Michael Heat, and mixtures thereof,wherein said cooling composition and said warming composition are located in distinct and discrete regions within said throat drop and said cooling and warming compositions being adapted to provide sequential release profiles.