Patent ID: 6017878
Filing Date: 2000-01-25
Classification: A61K,C07K

Abstract:
A compound that inhibits or mimics the biological activity of a neurotrophin, said compound havinga cyclic structure anda disulfide bridgewherein said compound binds to at least one neurotrophin receptor and comprises a peptide selected from the group consisting of:Z-X C K G K E C X; SEQ ID NO:1Z-X C D I K G K E C X; SEQ ID NO:2Z-X C T A I K G K E C X; SEQ ID NO:3Z-X C I K G K E C X; SEQ ID NO:4Z-X C I N N S V C X; SEQ ID NO:7Z-X C N I N N S V C X; SEQ ID NO:8Z-X C N I N N S C X; SEQ ID NO:9Z-X C S N P V E S C X; SEQ ID NO:12Z-X C A S N P V E S C X; SEQ ID NO:13X C A S N P V E C; SEQ ID NO:14X C A S N P V E C X; SEQ ID NO:15Z-X C T D E K Q C X; SEQ ID NO:18 andZ-X C T D E K Q A C X; SEQ ID NO:19wherein,X is any uncharged amino acid or hydropathic amino acid; andZ is absent or a protective group selected from the group consisting of Fmoc group and acetyl groups.