Patent ID: 7270801
Filing Date: 2007-09-18
Classification: C12Q,G01N,Y10S

Abstract:
1. A method to determine the sensitivity of an animal with cancer to treatment with one or more chemotherapeutic agents, comprising (a) contacting cancer cells taken from said animal with said one or more chemotherapeutic agents and a reporter compound having the Formula II: or the Formula V: or a biologically acceptable salt of said compound or a tautomer of said compound or a biologically acceptable salt of said tautomer, wherein: R each AA independently is a residue of an α-amino acid or β-amino acid, or a methyl, acetoxymethyl or methoxy ester of a carboxyl-containing α-amino acid or β-amino acid; each n independently is 0-5; y is a fluorogenic or fluorescent moiety comprising rhodamine; and R under conditions whereby said one or more agents, either interacts with an external receptor or is taken into said cancer cells, and (b) recording the fluorescence of said cancer cells compared to control cells which have only been contacted with said reporter compound, wherein a change in fluorescence of said cancer cells compared to said control cells is an indication that said cancer cells are chemosensitive to said one or more chemotherapeutic agents and that said animal is sensitive to said treatment.