Patent ID: 7731962
Filing Date: 2010-06-08
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody, or antigen-binding fragment thereof, capable of differentially recognizing a multi-dimensional conformation of one or more Aβ-derived diffusible ligands, wherein said antibody comprises a complementary determining region (CDR) of Arg-Xaa 1 -Leu-Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 -Asp-Ala-Met-Asp-Tyr (SEQ ID NO:9), wherein Xaa 1 is Gln or Ala; Xaa 2 is Ser or Gly; Xaa 3 is Pro, Ala, Lys, Arg, or Thr; Xaa 4 is Lys or Arg; Xaa 5 is Gly, Ser, or Lys; Xaa 6 is Val, Thr, Ile or Arg, wherein the heavy and light chain variable regions of said antibody respectively comprise the amino acid sequence set forth in SEQ ID NO:108 and SEQ ID NO:112.