Patent ID: 7232670
Filing Date: 2007-06-19
Classification: A61K,C12N,C12Y

Abstract:
1. A pharmaceutical composition comprising a protein useful for treating a lysosomal storage disorder other than Fabry disease that is selectively imported into macrophages when administered to a subject and a pharmaceutically acceptable carrier, wherein said protein is produced in an insect cell culture and is selected from the group consisting of acid α-1,4 glucosidase, acid α-1,6 glucosidase, β-galactosidase, β-hexosaminidase A, GM 2 Activator Protein, β-hexosaminidase A, β-hexosaminidase B, glucocerebrosidase, β-glucosidase, galactosylcerebrosidase, acid sphingomyelinase, acid ceramidase, acid lipase, α-L-iduronidase, iduronate sulfatase, α-N-acetylglucosaminidase, acetyl-CoA-glucosaminide acetyltransferase, N-acetylglucosamine-6-sulfatase, galactosamine-6-sulfatase, arvlsuylfatase B, β-glucuronidase, arylsulfatase A, arylsulfatase C, α-Neuraminidase, UDP GlcNAc:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase, neuraminidase, α-mannosidase, β-mannosidase, α-L-fucosidase, N-aspartyl-β-glucosaminidase, protective proteinlcathepsin A (PPCA), α-N-acetyl-galactosaminidase, cystine transport protein, sialic acid transport protein, palmitoyl-protein thioesterase, and Saposins A–D.