Patent ID: 8906503
Filing Date: 2014-12-09
Classification: A61K,C08G,C08J,C08L,C12N,Y10S,Y10T

Abstract:
1. A method of preparing fine particles of crystalline polyol having a cationic polymer fixed on the surface thereof, the method comprising freeze-drying an aqueous solution containing both a crystalline polyol and a cationic polymer and obtaining fine particles of crystalline polyol having a cationic polymer fixed on the surface thereof, wherein the cationic polymer is selected from the group consisting of polylysine; polyarginine; spermine; spermidine; polyethyleneimine; poly(polyamine-modified aspartamide); poly(polyamine-modified glutamide); and copolymers comprising blocks of polymer chains derived from polylysine, polyarginine, spermine, spermidine, polyethyleneimine, poly(polyamine-modified aspartamide), or poly(polyamine-modified glutamide); and blocks of polymer chains derived from poly(ethylene glycol), and the aqueous solution containing both a crystalline polyol and a cationic polymer is a mixture of a crystalline polyol aqueous solution with a concentration of 0.1 to 10 w/v % and a cationic polymer aqueous solution with a concentration of 1 to 1000 μg/mL.