Patent ID: 6767912
Filing Date: 2004-07-27
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I whereinQ is SO2; W is N or CR6; X is N or CR7; Y is NR8 or CR9R10; n is 0; Z is NR11 or CR12R13 with the proviso that when Y is NR8 then Z must be CR12R13 and at least one of Y and Z must be NR8 or NR11; R1, R2 and R7 are each independently H, halogen, CN, OCO2R14, CO2R15, CONR29R30, CNR16NR17R18, SOmR19, NR20R21, OR22, COR23 or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R3, R4, R9, R10, R12 and R13 are each independently H or an optionally substituted C1-C6alkyl group; R5 is an optionally substituted C1-C6alkyl, aryl or heteroaryl group; m is 0 or an integer of 1 or 2; R6 is H, halogen, or an optionally substituted C1-C6alkyl, C1-C6alkoxy, aryl or heteroaryl group; R8 and R11 are each independently H, CNR26NR27R28 or a C1-C6alkyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R14, R15, R22 and R23 are each independently H or an optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group; R16, R17, R18, R20, R21, R26, R27, R28, R29 and R30 are each independently H or C1-C4alkyl; R19 is an optionally substituted C1-C6alkyl, aryl or heteroaryl group; R24 and R25 are each independently H or an optionally substituted C1-C6alkyl, aryl or heteroaryl group; and ---- represents a single bond or a double bond; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.