Patent ID: 6306867
Filing Date: 2001-10-23
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR6##in whichof the group of symbols A, B, D and E, independently of one another, one symbol is N (nitrogen), one symbol is C-X and the remaining two symbols are C-H, whereX is hydrogen, hydroxyl, halogen, cyano, nitro, carboxyl, 1-4C-alkyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, amino, mono- or di-1-4C-alkylamino, 1-4C-alkylcarbonylamino, hydroxy-1-4C-alkyl, hydroxysulfonyl, 1-4C-alkysulfonyl, 1-4C-alkoxy-sulfonyl or sulfamoyl,Y is NH,R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,R2 is hydrogen or 1-4C-alkyl andR3 is hydrogen or 1-4C-alkyl,or in whichR2 and R3, together and including the two carbon atoms to which they are bonded, are a spiro-linked 5-, 6- or 7-membered hydrocarbon ring, if desired interrupted by an oxygen atom,or a salt a the N-oxide thereof.