Patent ID: 7030112
Filing Date: 2006-04-18
Classification: A61K,A61P,C07D

Abstract:
1. A compound selected from the group consisting of 3-Cyano-4-[4-(cyano-phenyl-methyl)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 2-[3-Cyano-6-ethoxycarbonyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-5-ylmethyl]-malonic acid diethyl ester, 5-Methyl-4-(4-phenoxy-phenylamino)-6-phenylamino-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid (2-amino-phenyl)-amide, 6-(1H-Benzoimidazol-2-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-2-fluoro-benzamide, 5-Methyl-6-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-Benzylamino-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-benzenesulfonamide, 6-[bis(phenylsulfonyl)amino]-5-methyl-4-[(4-phenoxyphenyl)amino]-7a-hydropyrrolo[1,2-e]pyridazine-3-carbonitrile, 6-(Benzothiazol-2-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, {4-[4-(6-Chloro-pyridazin-3-yloxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, {3-Cyano-5-methyl-4-[4-(1-phenyl-1H-tetrazol-5-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, {3-Cyano-5-methyl-4-[4-(2-nitro-phenoxy)-phenylamino]-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, {4-[4-(2-Amino-phenoxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, {4-[4-(2-Acetylamino-phenoxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, 5-Methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, [4-(4-Bromo-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester, {3-Cyano-4-[4-(2,2-dimethyl-3-oxo-2,3-dihydro-benzofuran-7-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, 4-(4-{2-[1-(tert-Butoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 4-(4-{2-[1-(Carboxymethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 4-(1-Benzyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-5-methyl-4-(4-phenoxy-benzenesulfonyl)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethylester, 3-Cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-5-methyl-4-[4-phenoxy-3-(tetrahydro-pyran-2-yloxymethyl)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(3-hydroxymethyl-4-phenoxy-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 6-(1-Hydroxy-1-methyl-ethyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, Trifluoro-methanesulfonic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester, 6-(1-Hydroxy-1methyl-ethyl)-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-Hydroxy-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 5,6-Dimethoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-(4-Methoxy-phenyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 5-Methyl-4-(4-phenoxy-phenylamino)-6-phenyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 7-Bromo-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 7-Chloro-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid ethyl ester, 7-Hydroxymethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid, 3-Cyano-5,7-dimethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 5-Methyl-6-(4-methyl-piperazin-1-ylmethyl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile [3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-ylmethoxy]-acetic acid ethylester, 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carbonyl-N-hydroxylacetamidine, 6-(Hydroxyimino-methyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, N-Benzyl-N-[3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-ylmethyl]-acetamide, N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-methanesulfonamide, 5-Methyl-6-(3-methyl-[1,2,4]oxadiazol-5-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methoxy-methyl-amide, 5-Methyl-4-(4-phenoxy-phenylamino)-6-propynoyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carbonyl-N-hydroxymorpholinyl-acetamidine, 5-Methyl-6-(3-morpholin-4-yl-[1,2,4]oxadiazol-5-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-(3-Methanesulfonylmethyl-[1,2,4]oxadiazol-5-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-(Imino-hydrazino-methyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 5-Methyl-4-(4-phenoxy-phenylamino)-6-(4-phenyl-thiazol-2-yl)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-(4,5-Dihydro-1H-imidazol-2-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-(2-Amino-4-hydroxy-4,5-dihydro-thiazol-4-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ether ester, 3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 1-{4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(2-morpholin-4-yl-ethyl)-urea, 3-Cyano-5-methyl-4-(5-phenoxy-pyridin-2-ylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Acetylamino-N-{3-cyano-4-[5-(2-methoxy-phenoxy)-pyridin-2-ylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, 3-Acetylamino-N-{3-cyano-4-[5-(2-methoxy-phenoxy)-pyridin-2-ylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, {3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-methyl-carbamic acid 2-morpholin-4-yl-ethyl ester, [3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methoxy-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-methanesulfonylamino-benzamide, 5-Methyl-6-morpholin-4-ylmethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 1-{3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(2-morpholin-4-yl-ethyl)-urea, 3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, {4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid, {3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester, 3-Cyano-5-methyl-4-(2-methyl-4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(2-fluoro-4-phenoxy-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid, 4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 4-(5-Bromo-pyridin-2-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, [3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester, 3-Cyano-4-(4-hydroxy-cyclohexylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(7-Aza-bicyclo[2.2.1]hept-7-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(4-tert-Butoxycarbonyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-5-methyl-4-piperazin-1-yl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(4-Benzoyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(1-tert-Butoxycarbonyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-4-(4-methanesulfonyl-piperazin-1-yl)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-5-methyl-4-(piperidin-4-ylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(1-Acetyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 6-Formyl-7-iodo-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, [3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 4-methanesulfonyl-butyl ester, 3-Cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, [3-Cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester, 4-{4-[2-(1-tert-Butoxycarbonyl-1-methyl-ethoxy)-phenoxy]-phenylamino}-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 4-{4-[2-(1-Carboxy-1-methyl-ethoxy)-phenoxy]-phenylamino}-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Acetylamino-N-[3-cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-benzamide, 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-(4-{2-[1-(ethoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-5-methyl-4-[4-phenoxy-3-(2,2,2-trifluoro-acetoxymethyl)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 5-Amino-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(4-{2-[1-(tert-Butoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 6-Hydroxy-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 7-Chloro-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 7-Bromo-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-{4-[2-(2,3-dihydroxy-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-5-methyl-4-(4-phenoxy-benzoylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-5-methyl-4-(4-phenoxy-benzenesulfonylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 6-{3-[2-(1,1-Dioxo-1l6-thiomorpholin-4-yl)-ethyl]-2-oxo-imidazoline-1-carbonyl]-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-5-methyl-4-[4-(pyridin-2-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-5-methyl-4-[4-(pyridin-4-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 3-Cyano-5-methyl-4-[4-(pyridin-3-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-Acetylamino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, 3-Acetylamino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-dimethylamino-benzamide, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-dimethylamino-benzamide, 1H-Benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 1H-Benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 4-Benzenesulfonyl-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 6-Isopropenyl-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yloxy]-propane-1-sulfonic acid, (3-Morpholin-4-yl-propyl)-carbamic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester, 5-Methyl-4-(4-phenoxy-phenylamino)-6-pyridin-2-yl-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 3-Cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid, (2-Morpholin-4-yl-ethyl)-carbamic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester, (2-Morpholin-4-yl-ethyl)-carbamic acid 3-cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester, 3-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yloxycarbonylamino]-propionic acid, 6-(3H-Imidazol-4-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo]1,2-b]pyridazine-3-carbonitrile, Furan-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, Thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 3-Cyano-4-{4-[2-(3-hydroxy-2,2-bis-hydroxymethyl-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-morpholin-4-yl-benzamide, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-2-methanesulfonyl-benzamide, 2-Oxo-imidazolidine-1-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, Benzo[1,2,5]thiadiazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 5-Methanesulfonyl-thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide 3-Chloro-4-methanesulfonyl-thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, [1,2,3Thiadiazole-4-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 3,5-Bis-acetylamino-N-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-d]pyridazin-6-yl}-benzamide, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide; trifluoro-acetic acid salt, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-nitro-benzamide, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-nitro-benzamide, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-guanidino-benzamide; trifluoro-acetic acid salt, 3-Amino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-ureido-benzamide, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-ureido-benzamide, trifluoro-acetic acid salt, N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide, trifluoro-acetic acid salt, 3,4-Bis-acetylamino-N-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide, 2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 2,3-Dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, Thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide, 1H-Imidazole-2-carboxylic acid [3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-amide, 5-Methyl-4-(4-phenoxy-phenylamino)-7-phenyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyrimidin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-guanidine; trifluoro-acetic acid salt, 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyridin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 6-(Di-pyrazin-2-yl-amino)-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile, 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyrazin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile, Acetic acid (3-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-ylcarbamoyl}-phenylcarbamoyl)-methyl ester, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-nitro-benzamide, 4-(1-Benzoyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 4-(4-Acetyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(3-ethyl-ureido)-benzamide, 3-Cyano-5,7-dimethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester, 7-Chloro-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 7-Bromo-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-{4-[2-(2,3-dihydroxy-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-{4-[2-(3-hydroxy-2,2-bis-hydroxymethyl-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, 3-Cyano-4-{4-[2-(2-hydroxy-ethoxy)phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, and 3-Cyano-4-(4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, or a pharmaceutically acceptable salt thereof.