Patent ID: 7268234
Filing Date: 2007-09-11
Classification: C07D

Abstract:
1. A one-pot method of manufacturing 1,2-benzisoxazole-3-methanesulfonamide, which comprises: (a) providing a first mixture of 1,2-benzisoxazole-3-methanesulfonic acid and toluene by a method, which comprises: adding chlorosulfonic acid, optionally mixed with an inert solvent, to a mixture of 1,2-benzisoxazole-3-acetic acid, toluene and a Lewis base selected from the group consisting of a C (b) adding aqueous alkali metal hydroxide solution to the first mixture and removing water by azeotropic distillation to give a second mixture; (c) adding phosphorous oxychloride to the second mixture and reacting the mixture to give a third mixture; (d) adding ammonia to the third mixture and reacting the mixture to give a fourth mixture containing 1,2-benzisoxazole-3-methanesulfonamide; and (e) isolating the 1,2-benzisoxazole-3-methanesulfonamide.