Patent ID: 6821978
Filing Date: 2004-11-23
Classification: A61P,C07D

Abstract:
A compound of Formula (I), an enantiomer, stereoisomer, rotomer, tautomer or a pharmaceutically acceptable salt thereof: where, (a) R1 and R2 are, independently of one another, each a C1-15 alkyl group, branched or straight chain, unsubstituted or substituted with one or more substituents, a C2-15 alkenyl group, branched or straight chain, unsubstituted or substituted with one or more substituents, a C2-15 alkynyl group, branched or straight chain, unsubstituted or substituted with one or more substituents, a C3-15 cycloalkyl group, unsubstituted or substituted with one or more substituents, an arylalkyl group, unsubstituted or substituted with one or more substituents, an aryl group, unsubstituted or substituted with one or more substituents, a heteroaryl group, unsubstituted or substituted with one or more substituents, â€”OR5, â€”COOR5, â€”C(O)R5 or â€”C(O)N(R5)2, where, R5 is a hydrogen atom or a hydrocarbon radical, unsubstituted or substituted with one or more substituents, or one of R1 and R2 is a hydrogen atom and the other one of R1 and R2 is defined the same as above; (b) R3 is an aryl group, unsubstituted or substituted with one or more substituents, a heteroaryl group, unsubstituted or substituted with one or more substituents, or a heterocyclic group having 1 to 3 heteroatoms fused to a 5- or 6-membered aryl ring, unsubstituted or substituted with one or more substituents, with the proviso that R3 is not an aryl group substituted at its para position with a â€”Y-aryl group, where, Y is a carbonâ€”carbon single bond, â€”C(O)â€”, â€”Oâ€”, â€”Sâ€”, â€”N(R21)â€”, â€”C(O)N(R22)â€”, â€”N(R22)C(O)â€”, â€”OCH2â€”, â€”CH2Oâ€”, â€”SCH2â€”, â€”CH2Sâ€”, â€”N(H)C(R23)(R24)â€”, â€”N(R23)S(O2)â€”, â€”S(O2)N(R23)â€”, â€”(R23)(R24)N(H)â€”, â€”CH&boxH;CHâ€”, â€”CF&boxH;CFâ€”, â€”CH&boxH;CFâ€”, â€”CF&boxH;CHâ€”, â€”CH2CH2â€”, â€”CF2CF2â€”, where, R21 is a hydrogen atom or a â€”CO(C1-4 alkyl), C1-6 alkyl, allyl, C3-6 cycloalkyl, phenyl or benzyl group; R22 is a hydrogen atom or a C1-6 alkyl group; R23 is a hydrogen atom or a C1-5 alkyl, aryl or â€”CH2-aryl group; R24 is a hydrogen atom or a C1-4 alkyl group; R25 is a hydrogen atom or a C1-8 alkyl, C1-8 perfluoroalkyl, C3-6 cycloalkyl, phenyl or benzyl group; R26 is a hydrogen atom or a C1-6 alkyl, C3-6 cycloalkyl, phenyl or benzyl group; R27 is â€”NR23R24, â€”OR24, â€”NHCONH2, â€”NHCSNH2, and R28 and R29 are, independently of one another, each a C1-4 alkyl group or, taken together with each other, a â€”(CH2)q group, where q is 2 or 3; and (c) R4 is a C3-15 cycloalkyl group, with or without unsubstituted or substituted with one or more substituents, or a C3-15 cycloalkenyl group, unsubstituted or substituted with one or more substituents; wherein, the one or more substituents for all the groups are chemically-compatible and are, independently of one another, each an: alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, arylalkyl, alkylaryl, aryl, heteroaryl, heterocycloalkyl, hydroxyalkyl, arylalkyl, aminoalkyl, haloalkyl, thioalkyl, alkylthioalkyl, carboxyalkyl, imidazolylalkyl, indolylalkyl, mono-, di- and trihaloalkyl, mono-, di- and trihaloalkoxy, amino, alkylamino, dialkylamino, alkoxy, hydroxy, halo, nitro, oximino, â€”COOR50, â€”COR50, â€”SO2R50, â€”SO2NR50R51, NR52SO2R50, &boxH;C(R50R51), &boxH;Nâ€”OR50, &boxH;Nâ€”CN, &boxH;C(halo)2, &boxH;S, &boxH;O, â€”CON(R50R51), â€”OCOR50, â€”OCON(R50R51), â€”N(R52)CO(R50), â€”N(R52)COOR50 or â€”N(R52)CON(R50R51) group, where: R50, R51 and R52 are, independently of one another, each a hydrogen atom or a branched or straight-chain, optionally substituted, C1-6 alkyl, C3-6 cycloalkyl, C4-6 heterocycloalkyl, heteroaryl or aryl group, or R50 and R51 are joined together to form a carbocyclic or heterocyclic ring system, or R50, R51 and R52 are, independently of one another, each: where, R40 and R41 are, independently of one another, each a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl, cycloalkyl, heterocycloalkyl, halo, aryl, imidazolylalkyl, indolylalkyl, heteroaryl, arylalkyl, arylalkoxy, heteroarylalkyl, heteroarylalkoxy, aminoalkyl, haloalkyl, mono-, di- or trihaloalkyl, mono-, di- or trihaloalkoxy, nitro, cyano, alkoxy, hydroxy, amino, phosphino, phosphate, alkylamino, dialkylamino, formyl, alkylthio, trialkylsilyl, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, morpholino, thioalkyl, alkylthioalkyl, carboxyalkyl, oximino, â€”COOR50, â€”COR50, â€”SO0-2R50, â€”SO2NR50R51, â€”NR52SO2R50, â€”CON(R50R51), â€”OCON(R50R51), â€”N(R52)CO(R50), â€”N(R52)COOR50, â€”N(R52)CON(R50R51) or â€”OCONR50 group, where, R50, R51 and R52 are defined the same as above; R42 is a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl, alkenyl, arylalkyl or acyl group; and R43 is a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl or aryl group; wherein, the optional substituents are defined the same as above for the one or more substituents.