Patent ID: 6177587
Filing Date: 2001-01-23
Classification: C07C

Abstract:
A method for producing a compound of the formula: ##STR27##wherein the ring A is a benzene ring which may have an optional substituent selected from (1) halogen, (2) cyano, (3) a nitro group, (4) an optionally substituted lower (C.sub.1-4) alkyl, (5) a lower (C.sub.1-4) alkoxy, (6) an optionally substituted amino group, (7) a group of the formula: --CO--D' wherein D' is hydroxy group or an optionally substituted lower (C.sub.1-4) alkoxy whose alkyl moiety may be substituted with hydroxy group, a lower (C.sub.1-4) alkoxy, a lower (C.sub.2-6) alkanoyloxy, a lower (C.sub.1-6) alkoxy-carbonyloxy, a lower (C.sub.3-6) cycloalkoxycarbonyloxy or (8) tetrazolyl, trifluoromethanesulfonamido group, phosphono group, sulfo group, each of which may be protected by an optionally substituted lower (C.sub.1-4) alkyl or acyl; in addition to the group R.sup.2, the nitro group and the group of the formula: ##STR28##R.sup.1 is a group capable of forming an anion or transformable thereinto;R.sup.2 is a group capable of forming an anion or transformable thereinto;R.sup.3 is an acyl group; andX is a direct bond, a lower (C.sub.1-4) alkylene in which the number of atoms composing the straight chain is 1 or 2, --CO--, --O--, --S--, --NH--, --CO--NH--, --O--CH.sub.2 --, --S--CH.sub.2 -- or --CH.dbd.CH--; or a salt thereof,said method comprises reacting a mixture containing(i) a mono-halogeno compound of the formula: ##STR29##wherein Y is a halogen atom and the other symbols are as defined above, or a salt thereof and(ii) a di-halogeno compound of the formula: ##STR30##wherein each symbol is as defined above, or a salt therof, wherein, in said mixture, the di-halogeno compound is present in an amount of about 1/20 to 1 mole per mol of the mono-halogeno compound, with a compound of the formula: ##STR31##wherein the ring A is a benzene ring which may have an optional substituent as defined above in addition to the group R.sup.2, the nitro group and the group of formula: --NHR.sup.3 and the other symbols are defined above, or a salt thereof.