Patent ID: 6403626
Filing Date: 2002-06-11
Classification: C07D

Abstract:
A method for treating an alpha-2 adrenergic receptor associated disorder in a subject which comprises administering to the subject an amount of a compound effective to treat the disorder, wherein the compound has the structure: wherein each of R1, R3 and R9 is independently H; straight chain or branched, substituted or unsubstituted C1-C7 alkyl, C2-C7 alkenyl or alkynyl; C3-C7 cycloalkyl or cycloalkenyl; or phenyl or substituted phenyl;wherein R2 is straight chain or branched, substituted or unsubstituted C1-C7 alkyl, C2-C7 alkenyl or alkynyl; C3-C7 cycloalkyl or cycloalkenyl; or phenyl or substituted phenyl; wherein each dashed line represents a single bond or a double bond with the proviso that if R1 is present, R3 is absent and there is a double bond between N at position 3 and C at position 2 and a single bond between C at position 2 and N at position 1 and if R3 is present, R1 is absent, there is a double bond between N at position 1 and C at position 2 and a single bond between C at position 2 and N at position 3; wherein R4 is F, Cl, Br, I; straight chain or branched, substituted or unsubstituted C2-C7 alkynyl; C3-C7 cycloalkyl or cycloalkenyl; or phenyl, substituted phenyl, â€”COR7, â€”CO2R7, â€”CON(R7)2,â€”OCOR7, â€”N(R7)2, â€”NR7COR7, â€”(CH2)nOR7, â€”(CH2)nN(R7)2, or â€”(CH2)nNR7COR7, wherein n is an integer from 1 to 4; wherein R5 is H; wherein R6 is H, F, Cl, Br, I; straight chain or branched, substituted or unsubstituted C1-C7 alkyl, C2-C7 alkenyl or alkynyl; C3-C7 cycloalkyl or cycloalkenyl; or phenyl, substituted phenyl, â€”OH, â€”OR7, â€”CN, â€”COR7, â€”CO2R7, â€”CON(R7)2, â€”OCOR7, â€”SR7, â€”N(R7)2, â€”NR7COR7, â€”(CH2)nOR7, â€”(CH2)nN(R7)2, or â€”(CH2)nNR7COR7; wherein each of R7 and R8 is independently H; straight chain or branched, substituted or unsubstituted C1-C7 alkyl, C2-C7 alkenyl or alkynyl; or phenyl or substituted phenyl; and wherein any substitutent if present is selected from a group consisting of F, â€”NH2, â€”OH, cyclohexyl, phenyl, or methoxyphenyl.