Patent ID: 6384260
Filing Date: 2002-05-07
Classification: C07F

Abstract:
A phosphoinositide analogue based on di-O-fattyacyl (or alkyl)-sn-glycero-3â€²-phospho-myo-inositol or di-O-fattyacyl (or alkyl)-sn-glycero-3â€²-phospho-scyllo-inositol having at least one additional hydroxyl group derivatized as a phosphate, wherein said phosphoinositide analogue incorporates one or more of the following modifying structural features:(a) the 2-OH is rendered non-nucleophilic by derivatization or replacement; or (b) a reporter group or conjugand is incorporated in the fatty acyl or inositol residue; wherein the core structure and absolute stereochemistry of the unmodified di-O-fattyacyl (or alkyl)-sn-glycero-3â€²-phospho-myo-inositol phosphate or di-O-fattyacyl (or alkyl)-sn-glycero-3â€²-phospho-scyllo-inositol phosphate is maintained in said phosphoinositide analogue.