Patent ID: 8568718
Filing Date: 2013-10-29
Classification: A61P,C07K

Abstract:
1. A method for treating nonhematopoietic cancer in an individual having cancer comprising administering to the individual an effective amount of a composition comprising a humanized antibody, wherein the antibody specifically binds to a carbohydrate epitope on a CD43 or a carcinoembryonic antigen (CEA) expressed by the nonhematopoietic cancer cells in the individual, wherein the antibody comprises a heavy chain and a light chain, wherein (a) the heavy chain comprises a heavy chain variable region comprising the three complementarity determining regions (CDRs) from the amino acid sequence of SEQ ID NO:1, and a heavy chain constant region comprising the amino acid sequence of SEQ ID NO:9, wherein the hinge region of the heavy chain constant region comprises at least one amino acid insertion, deletion or substitution; and (b) the light chain comprises a light chain variable region comprising the three complementarity determining regions (CDRs) from the amino acid sequence of SEQ ID NO:2, and a light chain constant region comprising the amino acid sequence of SEQ ID NO:10 and further comprising at least one amino acid insertion in the constant region, wherein the nonhematopoietic cancer is colorectal, pancreatic, or gastric cancer.