Patent ID: 7175844
Filing Date: 2007-02-13
Classification: A61K,C12Q,G01N

Abstract:
1. A method of decreasing fibrosis in a tissue of a subject, the method comprising: identifying a subject in need of decreased fibrosis, wherein the subject has a disorder selected from the group consisting of scleroderma; keloids; kidney fibrosis; pulmonary fibrosis; cardiac fibrosis; chemotherapy/radiation induced lung fibrosis; pancreatitis; inflammatory bowel disease; Crohn's disease; hypertrophic scar; nodular fasciitis; eosinophilic fasciitis; Dupuytren's contracture; general fibrosis syndrome, characterized by replacement of normal muscle tissue by fibrous tissue in varying degrees; retroperitoneal fibrosis; liver fibrosis; and acute fibrosis; and administering to the subject an antibody or antigen-binding fragment thereof that binds to VEGF receptor 1 (VEGFR1) and inhibits a VEGF-VEGFR1 signalling activity, thereby decreasing fibrosis in the tissue of the subject.