Patent ID: 9222088
Filing Date: 2015-12-29
Classification: A61K,A61P,C12N,C12Y,G01N

Abstract:
1. A method of upregulating a function of and/or the expression of an Alpha-L-Iduronidase (IDUA) polynucleotide having SEQ ID NO: 1 in a biological system comprising: contacting said biological system with at least one single stranded antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 consecutive nucleotides within the natural antisense transcript nucleotides 1 to 2695 of SEQ ID NO: 2 or 1 to 2082 of SEQ ID NO: 3 or 1 to 2739 of SEQ ID NO: 9; thereby upregulating a function of and/or the expression of the Alpha-L-Iduronidase (IDUA) polynucleotide.