Patent ID: 7611847
Filing Date: 2009-11-03
Classification: C12Q,G01N

Abstract:
1. A method for identifying a compound inhibiting the development of an intestinal phenotype in one or more gastric cells which are in a precancerous state, the method comprising: (a) contacting said one or more gastric cells with a solution supposed to contain at least one compound to be identified; (b) incubating said cells for a predetermined period of time; and (c) measuring the expression of the RUNX3 gene and the expression of said one or more intestinal marker genes, wherein said intestinal phenotype is characterized by the loss of expression of the RUNX3 gene and a change in the expression of one or more intestinal marker genes such that the level of said one or more marker genes is characteristic of said intestinal phenotype; wherein a compound inhibiting the development of an intestinal phenotype of one or more gastric cells is identified.