Patent ID: 8518649
Filing Date: 2013-08-27
Classification: A61K,G01N

Abstract:
1. A method for constructing a stress response (SR) pathway profile for a subject, comprising: (i) constructing a panel of at least 3 stress response (SR) biomarkers; (ii) obtaining a biological sample from the subject containing the SR biomarkers in the panel; (iii) determining quantitative immunochemical measurements of the SR biomarkers in the panel by computerized image analysis of staining intensity (SI); (iv) calculating biomarker scores of the SR biomarkers in the panel based on the staining intensity, wherein a score of 0 represents a baseline score for a normal control; and (v) calculating a pathway profile score (Z) from the biomarker scores according to an equation of Formula I: where; Z is a SR pathway profile; Z y f (vi) comparing the pathway profile score from the sample to the pathway profile score of normal control, wherein pathways having a difference in score in the sample as compared to the normal control are included in an SR pathway profile.