Patent ID: 6506936
Filing Date: 2003-01-14
Classification: A61P,C07C,C07D

Abstract:
A compound having an inhibitory effect on C-proteinase and having the structural formula: or pharmaceutically acceptable salts thereof, wherein:a is an integer from 2 to 4; b is an integer from 0 to 4; c is an integer from 0 to 4; Ar1 is selected from the group consisting of (C5-C20) aryl, (C5-C20) aryl independently substituted with one or more Y1, 5-20 membered heteroaryl, and 5-20 membered heteroaryl independently substituted with one or more Y1; Ar2 is selected from the group consisting of (C5-C20) aryl, (C5-C20) aryl independently substituted with one or more Y2, 5-20 membered heteroaryl, and 5-20 membered heretoaryl independently substituted with one or more Y2; each Y1 is independently selected from the group consisting of an electron-donating functional group, an electron-withdrawing functional group, and a lipophilic functional group; and each Y2 is independently selected from the group consisting of a functional group having an acidic hydrogen, a functional group capable of participating in a hydrogen bond, a polar functional group, an electron-withdrawing functional group, an electron-donating functional group, and a lipophilic functional group, with the proviso that when a is two, b and c are each zero and Ar1 is phenyl, then Ar2 is other than 4-chlorophenyl or 4-bromophenyl.