Patent ID: 9132172
Filing Date: 2015-09-15
Classification: A61K,A61L

Abstract:
1. A composition for treating organ dysfunction, comprising: an extracellular matrix (ECM) composition comprising ECM from a mammalian tissue source comprising small intestine submucosa, said ECM comprising endogenous proteoglycans, transforming growth factors-β (TGF-β), fibroblast growth factors-2 (FGF-2) and vascular endothelial growth factor (VEGF), said ECM further comprising an exogenously added cytokine, said cytokine comprising at least 0.1% by weight of said composition, said cytokine being linked to said ECM, wherein, when said composition is administered to biological tissue, said cytokine interacts with at least one molecule in said ECM composition, wherein said ECM composition modulates ROS production and, thereby, telomere activity.