Patent ID: 6379705
Filing Date: 2002-04-30
Classification: A61K

Abstract:
Stable pellet pharmaceutical preparations containing substituted benzimidazole(s) or their salts, characterized in that they contain a quantity of active ingredient of between 1 and 50 mg, an inert core of spherical symmetry with a diameter of 600-1000&mgr;, constituted by inert excipients, coated with an active layer containing at least one substituted benzimidazole or its salt in the micronized form, sodium tetraborate to improve the stability of the benzimidazole or its salt and various pharmaceutically acceptable inert excipients, mixed in suitable proportions in order to allow the disaggregation of the formulations and dissolution of the active ingredient(s), coated in turn with an insulating layer consisting of a water soluble polymer and any residual water, and being free from alkaline and/or alkaline-earthy metallic salts, of a minimum thickness of 15 &mgr;m, this layer being coated lastly with a gastroresistant or enteric layer of a minimum thickness of 30 &mgr;m.