Patent ID: 6822114
Filing Date: 2004-11-23
Classification: C07C,C07D

Abstract:
A process for the preparation of a 3,4-disubstituted benzoyl compound in which the substituent in the 3-position, R1, is a C1-6 alkoxy, C3-7 cycloalkoxy, C3-7 cycloalkylmethoxy, or benzyloxy group, or a C1-4 alkoxy group which is completely or partially substituted by fluorine, and in which the substituent in the 4-position, R2, is a C1-4 alkoxy group which is completely or partially substituted by fluorine, which process comprises:A) alkylating an ortho-R1-substituted para-halophenol in which the para-halo substituent is a chloro, bromo, or iodo substituent with an alkylating agent which is a C1-4 monohaloalkane in which the halo substituent is chloro, bromo, or iodo, and in which said monohaloalkane is otherwise completely or partially substituted by fluorine, to form a product comprised of a 1-halo-3,4-disubstituted benzene in which the substituent in the 3-position is R1, and in which the substituent in the 4-position is R2; and B) carbonylating 1-halo-3,4-disubstituted benzene from A) with carbon monoxide to form a product comprised of a 3,4-disubstituted benzoyl compound in which the substituent in the 3-position is R1, and in which the substituent in the 4-position is R2.