Patent ID: 8617879
Filing Date: 2013-12-31
Classification: B01L,C12M

Abstract:
1. An apparatus for cell or tissue culture, the apparatus comprising a base plate, an intermediate face and atop plate, the intermediate face being removably sandwiched between the base plate and the top plate, wherein the base plate has a circumferential wall a base and a top wall, wherein the top wall of the base plate comprises a plurality of recesses arranged in n lines, wherein n is an integer from 1 to about 25 and wherein each line of recesses ranges from a first recess to a last recess, each recess having a circumferential recess wall, wherein the circumferential recess wall of each recess has one recess inlet and one recess outlet, wherein the circumferential wall of the base plate comprises a number of 2 n ports, each port being coupled to a single line of recesses of said n lines, wherein the recesses of each line of recesses are in fluid communication with (i) each other via the recess inlets and the recess outlets and (ii) with a first and a second port of said 2 n ports, such that the first recess of each line of recesses is coupled to a first port and the last recess of each line of recesses is coupled to a second port, wherein the intermediate face has a plurality of recesses arranged in m lines fitted into the plurality of recesses of the top wall of the base plate, wherein m is an integer from 1 to about 25 equal to or smaller than n, and wherein the recesses of the intermediate face have water permeability, and wherein the top plate is reversibly sealed to the intermediate face and the intermediate face is reversibly sealed to the base plate, such that the recesses of the top wall of the base plate define culture chambers, each culture chamber having a circumferential wall defined by the recess wall and a removable top, the top being defined by a portion of the top plate.