Patent ID: 6316451
Filing Date: 2001-11-13
Classification: A61P,C07D

Abstract:
A compound of formula 1 ##STR21##wherein:R.sub.1 is selected from:hydrogen,hydroxy,a group of formula OR.sub.5 wherein R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.3 -C.sub.8 cycloalkyl,halogen andamino which may be unsubstituted or mono or disubstituted by C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, aralkyl, acyl or trifluoroacetyl;R.sub.2 is selected from:hydrogen,hydroxy anda group NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 independently represent hydrogen, an optionally substituted C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.8 cycloalkyl or, taken together with the nitrogen atom, represent an optionally substituted C.sub.3 -C.sub.8 heterocyclic ring;R.sub.3 is selected from:hydrogen andhydroxy;R.sub.4 is an heterocycle of formula A: ##STR22##wherein Z represents sulfur or nitrogen and R.sub.6 and R.sub.7 are as defined above and the pharmaceutically acceptable salt thereof.