Patent ID: 6153649
Filing Date: 2000-11-28
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A method of desquamating skin and/or promoting epidermal renewal in skin, comprising applying to the skin an effective amount of at least one carboxylic acid and/or a salt thereof represented by formula (I) (II) or (III): ##STR6## wherein n is an integer of a value ranging from 1 to 10,p.sub.1 and q.sub.1, which are identical or different, are 0, 1 or 2,n.sub.2 is an integer of a value ranging from 0 to 5,p.sub.2 is 0, 1 or 2,q.sub.2 is 0, 1 or 2,q.sub.2 is 0, 1, 2 or 3,m.sub.2 is an integer of a value ranging from 0 to 10,r.sub.2 is 0 or 1, q.sub.2 and n.sub.2 never both being zero simultaneously,R.sub.11 and R'.sub.11, which are identical or different, are a radical selected from the group consisting of ##STR7## wherein R.sub.12 and R.sub.13, which are identical or different, are selected from the group consisting of a hydrogen atom and C.sub.1 -C.sub.8 linear or branched alkyl or alkenyl radicals;R.sub.14 is selected from the group consisting of a hydrogen atom, linear or branched C.sub.1 -C.sub.8 alkyl radicals, linear or branched C.sub.1 -C.sub.8 alkenyl radicals and linear and branched C.sub.1 -C.sub.8 alkoxy radicals;R.sub.15 and R.sub.16 are selected from the group consisting of a hydrogen atom and linear or branched C.sub.1 -C.sub.8 alkoxy radicals;R.sub.21 and R.sub.22 are selected from the group consisting of a hydrogen atom and linear or branched C.sub.1 -C.sub.6 alkoxy and alkenyl radicals, phenyl, C.sub.1 -C.sub.6 alkylcarboxylic and C.sub.1 -C.sub.6 alkenylcarboxylic acid radicals;R.sub.23 is a C.sub.1 -C.sub.17 linear or branched alkyl or alkenyl radical or an acyl radical --CO--R.sub.24, where R.sub.24 is a C.sub.1 -C.sub.17 linear or branched alkyl or alkenyl radical;R.sub.25 is selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.6 linear or branched alkyl and alkenyl radical, a C.sub.1 -C.sub.5 alkyl-carboxylic acid radical, C.sub.1 -C.sub.5 alkenylcarboxylic acid radical and the function --COOH;R.sub.31 and R'.sub.31 are selected from the group consisting of ##STR8## R.sub.32 is a radical selected from the group consisting of i) --CH.sub.3ii) --CO.sub.2 H ##STR9## wherein R.sub.34 is a radical selected from the group consisting of --CH.sub.2 --CO.sub.2 H and --CO--CH.sub.3, andR.sub.35 is a radical selected from the group consisting of OH, OCH.sub.3, OC(CH.sub.3).sub.3, and OCH.sub.2 CO.sub.2 H,R.sub.33 is a radical selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.6 linear or branched alkyl or alkenyl radical, orR.sub.32 and R.sub.33 together form an alkane diyl radical --(CH.sub.2)m.sub.3 -- wherein m.sub.3 represents an integer of a value ranging from 3 to 5, orR.sub.32 and R.sub.33 together form an aralkanediyl radical represented by the formula ##STR10## wherein n.sub.3 is 3 or 4.