Patent ID: 8952134
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. An antibody comprising an immunoglobulin heavy chain constant region, comprising in order form N- to C-terminus CH2 and CH3 regions, each of which is of IgG or IgA isotype, and Cμ3 and Cμ4 regions, wherein the heavy chain constant region is fused to a heavy chain variable region and the antibody further comprises a light chain comprising a light chain variable region and constant region and the antibody is a component of a multi-specific antibody comprising a plurality of such antibodies with different heavy chain variable regions, and optionally different light chain variable regions; the plurality of antibodies being complexed in the multi-specific antibody via the Cμ3 and Cμ4 regions.