Patent ID: 6086867
Filing Date: 2000-07-11
Classification: A61K,A61P,C07K

Abstract:
A method of altering the level of TGF-.beta. binding to TGF-.beta. type III receptor on the surface of a cell, comprising contacting the cell with a preparation consisting essentially of a soluble polypeptide comprising the amino acid sequence of the extracellular domain of a mammalian TGF-.beta. type III protein, wherein the amino acid sequence of the mammalian receptor protein is:a) the amino acid sequence of the TGF-.beta. type III receptor protein of SEQ ID NO: 6 orb) the amino acid sequence of a TGF-.beta. receptor protein encoded by mammalian DNA which hybridizes to the complement of SEQ ID NO: 5 under high stringency conditions, andwherein the cell is contacted under conditions appropriate for binding of the soluble polypeptide to TGF-.beta..