Patent ID: 7851472
Filing Date: 2010-12-14
Classification: A61P,C07D

Abstract:
1. A compound of formula I in which R1 is -U-A, in which U is a direct bond, or methylene (—CH A is phenyl, pyridinyl, thiophenyl, or R11- and/or R111-substituted phenyl, in which R11 is 1-4C-alkyl, halogen, trifluoromethyl, hydroxyl, 1-4C-alkoxy, phenoxy, 1-4C-alkoxycarbonyl, morpholino, di-1-4C-alkylamino, or completely or predominantly fluorine-substituted 1-4C-alkoxy, R111 is 1-4C-alkoxy, halogen, hydroxyl, or 1-4C-alkyl, R2 is amino, carboxyl, 1-4C-alkoxycarbonyl, —N(H)—C(O)R3, or —C(O)—N(R4)R5, in which R3 is 1-4C-alkyl, 2-4C-alkenyl, 3-7C-cycloalkyl, trifluoromethyl, phenyl, R31- and/or R311-substituted phenyl, furanyl, imidazol-4-yl, pyridinyl, R32-substituted 1-4C-alkyl, or 1N-(R33)-piperidinyl, in which R31 is 1-4C-alkoxy, halogen, nitro, 1-4C-alkyl, trifluoromethyl, hydroxyl, 1-4C-alkoxycarbonyl, 3-7C-cyloalkylmethoxy, morpholino, or mono- or di-1-4C-alkylamino, R311 is 1-4C-alkoxy, halogen, 1-4C-alkyl, hydroxyl, or 3-7C-cyloalkylmethoxy, or R31 and R311 together are a 1-2C-alkylenedioxy group, R32 is hydroxyl, phenyl-1-4C-alkoxy, 1-4C-alkoxy, phenyl, R321- and/or R3211-substituted phenyl, mono- or di-1-4C-alkylamino, morpholino, or 4N-(R322)-piperazin-1-yl, in which R321 is 1-4C-alkoxy, halogen, nitro, 1-4C-alkyl, trifluoromethyl, hydroxyl, 1-4C-alkoxycarbonyl, 3-7C-cyloalkylmethoxy, or mono- or di-1-4C-alkylamino, R3211 is 1-4C-alkoxy, halogen, 1-4C-alkyl, hydroxyl, or 3-7C-cyloalkylmethoxy, or R321 and R3211 together are a 1-2C-alkylenedioxy group, R322 is 1-4C-alkyl, R33 is hydrogen, 1-4C-alkyl, or 1-4C-alkylcarbonyl, R4 is hydrogen, 1-4C-alkyl, R41-substituted 2-4C-alkyl, phenyl, R42- and/or R421-substituted phenyl, or pyridinyl, in which R41 is hydroxyl, 1-4C-alkoxy, mono- or di-1-4C-alkylamino, or morpholino, R42 is 1-4C-alkoxy, halogen, nitro, 1-4C-alkyl, trifluoromethyl, hydroxyl, 1-4C-alkoxycarbonyl, 3-7C-cyloalkylmethoxy, or mono- or di-1-4C-alkylamino, R421 is 1-4C-alkoxy, halogen, 1-4C-alkyl, hydroxyl, or 3-7C-cyloalkylmethoxy, or R42 and R421 together are a 1-2C-alkylenedioxy group, R5 is hydrogen, or 1-4C-alkyl, or R4 and R5 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring radical Het, in which Het is morpholino, or 4N-(1-4C-alkyl)-piperazin-1-yl, or a salt thereof.