Patent ID: 6114369
Filing Date: 2000-09-05
Classification: A61P,C07D

Abstract:
A benzimidazole compound of the formula (I) or a salt thereof: ##STR33## wherein A is a single bond or C.sub.1-2 alkylene, which is optionally substituted by C.sub.1-4 alkyl; R.sup.6 is hydrogen, C.sub.1-4 alkyl, which is optionally substituted by phenyl; B is C.sub.2-3 alkylene, which is optionally substituted by C.sub.1-4 alkyl; X is oxygen, sulfur, or NR.sup.7, wherein R.sup.7 is nitro, cyano or C.sub.1-4 alkoxy; each of R.sup.1 and R.sup.2 which are independent of each other, is hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; E is C.sub.1-2 alkylene, which is optionally substituted by C.sub.1-4 alkyl; R.sup.3 is phenyl, which is optionally substituted by halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, C.sub.1-4 alkoxy or benzyloxy; each of R.sup.4 and R.sup.5 which are independent of each other, is hydrogen, C.sub.1-4 alkyl, which is optionally substituted by phenyl; D is C.sub.1-2 alkylene, which is optionally substituted by C.sub.1-4 alkyl; and Ar is phenyl which is, optionally substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl.