Patent ID: 6407236
Filing Date: 2002-06-18
Classification: A61K,A61P,C07B,C07D,G01N

Abstract:
A compound of the following formula: wherein:A is imidazole, pyrazole, or triazole; R is â€”C(X)R1, â€”C(X)â€”N(R1)2, â€”C(X)OR1, â€”C(X)SR1, â€”SOnR1, â€”SOnSR1, or SOnâ€”N(R1)2; R1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl, heterocyclic, lower alkenyl, lower alkanoyl, or, if linked to a nitrogen atom, then taken together with the nitrogen atom, forms an azetidine ring or a 5-6 membered heterocyclic ring containing one or more heteroatoms; R2 is hydrogen, alkyl, substituted alkyl, alkenyl, aralkyl, substituted aralkyl, heteroaryl, substituted heteroaryl or aryl; R3 is furan, pyrrole, thiophene, benzofuran, benzypyrrole, benzothiophene, optionally substituted with one or more substituents selected from the group consisting of hydroxy, acyl, alkyl, alkoxy, alkenyl, alkynyl, substituted alkyl, substituted alkoxy, substituted alkenyl, substituted alkynyl, amino, substituted amino, aminoacyl, acyloxy, acylamino, alkaryl, aryl, aryloxy, azido, carboxyl, carboxylalkyl, cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, aminoacyloxy, thioalkoxy, substituted thioalkoxy, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-aryl, â€”SO-heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl, â€”SO2-aryl, â€”SO2-heteroaryl, and trihalomethyl; X is O, S, or NR1; and pharmaceutically acceptable salts thereof.