Patent ID: 8664357
Filing Date: 2014-03-04
Classification: C07H,C07K

Abstract:
1. A process for the preparation of a first compound selected from peptides, oligonucleotides, and peptide nucleic acids; the process comprising: (i) synthesising the first compound by liquid phase synthesis in an organic solvent; and (ii) separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of the first compound, wherein (a) the synthesis of the first compound in step (i) involves one or more coupling or deprotection reactions; (b) the first and second compounds are dissolved in an organic solvent and are separated by a process of diafiltration using a membrane that is stable in the organic solvent and which provides a rejection for the first compound which is greater than the rejection for the second compound; and (c) the process comprises subjecting the first compound to one or more coupling and/or deprotection reactions subsequent to separation.