Patent ID: 8153792
Filing Date: 2012-04-10
Classification: A61P,C07D

Abstract:
1. A process for manufacturing a compound of formula (I): or a salt thereof, wherein each of R m is 0-5 and n is 0-4, R (i) an aryl group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl, cyano and alkoxy; (ii) a heteroaryl group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl and alkoxy; (iii) a five-membered ring aromatic heterocyclic group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl, and alkoxy; the process comprising: with an intermediate of formula (Int4): wherein Ra can be methyl, trifluoromethyl, isopropyl or a phenyl optionally substituted and R wherein R wherein R wherein Rb is a hydroxyl, an alkoxy or a halogen group and R