Patent ID: 8575314
Filing Date: 2013-11-05
Classification: A61K,A61P,C07K,G01N

Abstract:
1. An isolated antibody that binds to a complex of oxidized LDL and β 2 -glycoprotein I (oxidized LDL/β 2 GPI complex) and comprises a pair of the heavy chain described in (a) or (b) below and the light chain described in (c) or (d) below: (a) an antibody comprising a heavy chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 2, CDR2 having the amino acid sequence of SEQ ID NO: 3, and CDR3 having the amino acid sequence of SEQ ID NO: 4; (b) an antibody comprising a heavy chain that comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO: 1; (c) an antibody comprising a light chain that comprises CDR1 having the amino acid sequence of SEQ ID NO: 7, CDR2 having the amino acid sequence of SEQ ID NO: 8, and CDR3 having the amino acid sequence of SEQ ID NO: 9; (d) an antibody comprising a light chain that comprises a light chain variable region having the amino acid sequence of SEQ ID NO: 6.