Patent ID: 6090366
Filing Date: 2000-07-18
Classification: A61K,A61P

Abstract:
A process for preparing of an organ-specific antibody or antibody F(ab').sub.2 fragment directly labeled with technetium-99m, comprising:(a) pretreating an organ-specific antibody or antibody F(ab').sub.2 fragment to produce a functional group having complex-forming ability on the antibody or antibody F(ab').sub.2 fragment,(b) combining a complexing agent with a reducing agent, wherein the complexing agent and reducing agent are present in stoichiometric quantities to produce a complex-stabilized reducing agent, and(c) mixing the pretreated antibody or antibody F(ab').sub.2 fragment from (a) with pertechnetate-99 m and the complex stabilized-reducing agent from (b).