Patent ID: 6204262
Filing Date: 2001-03-20
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR119##or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein:A is O or S;B is NR.sup.8 ;W is CR.sup.3 ;X is CR.sup.3a ;Y is CR.sup.3b ;Z is CR.sup.3c ;R.sup.1 is selected from the group C.sub.1-3 alkyl substituted with 0-7 halogen and cyclopropyl;R.sup.2 is selected from the group --R.sup.2c, --OR.sup.2c, --OCHR.sup.2a R.sup.2b, --OCH.sub.2 CHR.sup.2a R.sup.2b, --O(CH.sub.2).sub.2 CHR.sup.2a R.sup.2b, --OCHR.sup.2a C.dbd.C--R.sup.2b, --OCHR.sup.2a C.dbd.R.sup.2c, 13 OCHR.sup.2a C.tbd.C--R.sup.2b, --SR.sup.2c, --SCHR.sup.2a R.sup.2b, --SCH.sub.2 CHR.sup.2a R.sup.2b, --S(CH.sub.2).sub.2 CHR.sup.2a R.sup.2b, --SCHR.sup.2a C.dbd.C--R.sup.2b, --SCHR.sup.2a C.dbd.R.sup.2c, --SCHR.sup.2a C.tbd.C--R.sup.2b, --NR.sup.2a R.sup.2c, --NHCHR.sup.2a R.sup.2b, --NHCH.sub.2 CHR.sup.2a R.sup.2b, --NH(CH.sub.2).sub.2 CHR.sup.2a R.sup.2b, --NHCHR.sup.2a C.dbd.C--R.sup.2b, --NHCHR.sup.2a C.dbd.R.sup.2c, and --NHCHR.sup.2a C.tbd.C--R.sup.2b ;R.sup.2a is selected from the group H, CH.sub.3, CH.sub.2 CH.sub.3, CH(CH.sub.3).sub.2, and CH.sub.2 CH.sub.2 CH.sub.3 ;R.sup.2b is H or R.sup.2c ;R.sup.2c is selected from the group C.sub.1-6 alkyl substituted with 0-2 R.sup.4, C.sub.2-5 alkenyl substituted with 0-2 R.sup.4, C.sub.2-5 alkynyl substituted with 0-1 R.sup.4, C.sub.3-6 cycloalkyl substituted with 0-2 R.sup.3d, phenyl substituted with 0-2 R.sup.3d, and 3-6 membered heterocyclic group containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R.sup.3d ;alternatively, the group --NR.sup.2a R.sup.2c represents a 4-7 membered cyclic amine, wherein 0-1 carbon atoms are replaced by O or NR.sup.5 ;R.sup.3 is selected from the group H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, --SO.sub.2 NR.sup.5 R.sup.5a, and a 5-6 membered heteroaromatic ring containing 1-4 heteroatoms selected from the group O, N, and S;R.sup.3a is selected from the group H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, --SO.sub.2 NR.sup.5 R.sup.5a, and a 5-6 membered heteroaromatic ring containing 1-4 heteroatoms selected from the group O, N, and S;alternatively, R.sup.3 and R.sup.3a together form --OCH.sub.2 O--;R.sup.3b is selected from the group H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, and --SO.sub.2 NR.sup.5 R.sup.5a ;alternatively, R.sup.3a and R.sup.3b together form --OCH.sub.2 O--;R.sup.3c is selected from the group H, C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, and --SO.sub.2 NR.sup.5 R.sup.5a ;alternatively, R.sup.3b and R.sup.3c together form --OCH.sub.2 O--;R.sup.3d, at each occurrence, is independently selected from the group C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, and --SO.sub.2 NR.sup.5 R.sup.5a ;R.sup.3e, at each occurrence, is independently selected from the group C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, and --SO.sub.2 NR.sup.5 R.sup.5a ;R.sup.3f, at each occurrence, is independently selected from the group C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, and --SO.sub.2 NR.sup.5 R.sup.5a ;R.sup.3g, at each occurrence, is independently selected from the group C.sub.1-4 alkyl, --OH, C.sub.1-4 alkoxy, OCF.sub.3, F, Cl, Br, I, --NR.sup.5 R.sup.5a, --NO.sub.2, --CN, --C(O)R.sup.6, --NHC(O)R.sup.7, --NHC(O)NR.sup.5 R.sup.5a, --NHSO.sub.2 R.sup.10, --SO.sub.2 NR.sup.5 R.sup.5a, C.sub.3-10 carbocycle substituted with 0-3 R.sup.3f and a 5-10 membered heterocyclic group containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-3 R.sup.3f ; and,R.sup.4 is selected from the group F, Cl, Br, I, C.sub.1-6 alkyl substituted with 0-2 R.sup.3e, C.sub.3-10 carbocycle substituted with 0-2 R.sup.3e, phenyl substituted with 0-5 R.sup.3e, and a 5-10 membered heterocyclic group containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R.sup.3e ;R.sup.5 and R.sup.5a are independently selected from the group H and C.sub.1-4 alkyl;alternatively, R.sup.5 and R.sup.5a, together with the nitrogen to which they are attached, combine to form a 5-6 membered ring containing 0-1 O or N atoms;R.sup.6 is selected from the group H, OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and NR.sup.5 R.sup.5a ;R.sup.7 is selected from the group C.sub.1-3 alkyl and C.sub.1-3 alkoxy;R.sup.8 is selected from the group H, OR.sup.9, SR.sup.9, NR.sup.5 R.sup.9, C.sub.1-6 alkyl substituted with 0-3 R.sup.3g, C.sub.2-6 alkenyl substituted with 0-3 R.sup.3g, C.sub.2-6 alkynyl substituted with 0-3 R.sup.3g, C.sub.3-5 cycloalkyl substituted with 0-2 R.sup.3f, phenyl substituted with 0-5 R.sup.3f, and a 5-6 membered heterocyclic group containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R.sup.3f ;R.sup.9 is selected from the group C.sub.3-10 carbocycle substituted with 0-5 R.sup.3f and a 5-10 membered heterocyclic group containing 1-3 heteroatoms selected from the group O, N, and S, substituted with 0-2 R.sup.3f ; and,R.sup.10 is selected from the group C.sub.1-4 alkyl and phenyl.