Patent ID: 6265375
Filing Date: 2001-07-24
Classification: A61K,A61P,C07C,C07K,Y02P

Abstract:
A backbone cyclized peptide analog having the general Formula (I): ##STR47##wherein: a and b each independently designates an integer from 1 to 8 or zero; d, e, and f each independently designates an integer from 1 to 10; (AA) designates an amino acid residue wherein the amino acid residues in each chain may be the same or different; E represents a hydroxyl group, a carboxyl protecting group or an amino group, or CO--E can be reduced to CH.sub.2 --OH; each of R, R', R"", and R'"" is independently hydrogen or an amino acid side-chain optionally bound with a specific protecting group; and the lines designate a bridging group of the Formula:(i) --X--M--Y--W--Z--; or (ii) --X--M--Z--wherein: one line may be absent; M and W are independently selected from the group consisting of disulfide, amide, thioether, thioester, imine, ether, and alkene; and X, Y and Z are each independently selected from the group consisting of alkylene, substituted alkylene, arylene, homo- or hetero-cycloalkylene and substituted cycloalkylene.