Patent ID: 7601730
Filing Date: 2009-10-13
Classification: A61P,C07D

Abstract:
1. A method to treat a disease in a subject in need thereof, said method comprising administering to said subject an effective amount of a compound, or a salt thereof having the formula wherein: X is CH; Y is oxygen; Z is oxygen; R is CO R R R R R or an enantiomer thereof; wherein said disease is selected from the group consisting of hypertension, pulmonary hypertension, myocardial infarction, angina pectoris, acute kidney failure, renal insufficiency, cerebral vasospasms, cerebral ischemia, subarachnoid hemorrhages, asthma, atherosclerosis, intravascular coagulation, restenosis after angioplasty, hypertension caused by ischemia or intoxication, kidney failure caused by ischemia or intoxication, Raynaud's syndrome, and asthmatic airway condition.