Patent ID: 6353111
Filing Date: 2002-03-05
Classification: A61P,C07C,C07D

Abstract:
Compound selected from the group consisting of an olefinic amide of the formula: wherein R1 and R2 are independently hydrogen, halo, amino, nitro, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, lower alkyl sulfonyl methyl, perfluoro-lower alkyl sulfonyl, or lower alkyl sulfinyl;R is â€”(CH2)mâ€”R3 or lower alkyl containing from 2 to 4 carbon atoms; R3 is cycloalkyl having from 3 to 8 carbon atoms; R4 is â€ƒor an unsubstituted or a mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 2 heteroatoms selected from the group consisting of sulfur, or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of halo or m is 0 or 1; n is 0, 1, 2, 3 or 4; R7 is hydrogen or lower alkyl; and &Dgr; denotes a trans configuration across the double bond; or a pharmaceutically acceptable salt thereof.