Patent ID: 6960573
Filing Date: 2005-11-01
Classification: A61P,C07C,C07F,Y02P

Abstract:
1. A method for treating an inflammatory respiratory disease comprising administering to a subject a therapeutically effective amount of a vitamin D 3 compound expressed by the following general formula (1) or pharmaceutically permissible solvates thereof, wherein, R 01 and R 02 are each independently a hydrogen atom, a trimethylsilyl group, a triethylsilyl group, a t-butyldimethylsilyl group, an acetyl group, a methoxymethyl group or a tetrahydro-4H-pyran-2-yl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) or (1-5), in the above formulae (1-1) to (1-5), m is an integer of 0 to 2; n is an integer of 0 to 2; X′ is an oxygen atom or NH; R K, L and M are each a hydrogen atom; M is a hydrogen atom, and K and L together express a single bond and express a double bond in cooperation with the single bond already shown in the formula; or K is a hydrogen atom, and L and M together express a single bond and express a double bond in cooperation with the single bond already shown in the formula; R Q expresses >C(—F—R R A and B are identical to or different from each other, and they express a hydrogen atom or a hydroxyl group, or together express a single bond and form a double bond in cooperation with the single bond already shown in the formula; X and Y together express a carbonyl group in cooperation with the carbon atom to which they are bonded, one of them is a hydrogen atom and the other is a hydroxyl group, or one of them is a hydrogen atom and the other is a C R R R D and F express each a hydrogen atom, D is a hydroxy group and E expresses a hydrogen atom, D and E together express a single bond and express a double bond in cooperation with the single bond already shown in the formula, or E and R R R with the proviso that the following compounds (a), (b) and (c) are excluded, (a) a compound in which the groups of one combination out of R (b) a compound expressed by the above formula (1) in which Z is the following formula (1-6), wherein, p and q are each 0 or the integer 1; R 6 is a hydrogen atom or a C 1 -C 4 alkyl group, and (c) a compound of the following formula (2), wherein, R 01 and R 02 are defined in the same manner as in the above formula (1); the configuration of the carbon atom at the 20-position is (R)-configuration; R 7 is a methyl group or a methylene group; when R 7 is a methylene group, the bond between R 7 and the carbon atom at the 26-position is double bond.