Patent ID: 6500461
Filing Date: 2002-12-31
Classification: A61K

Abstract:
A particle which comprises:(a) a core comprising a poorly hydrophilic compound wherein said core is substantially free of water and added oil such that the particle is neither a liposome nor an emulsion; (b) a conjugate of a biocompatible hydrophilic domain and a biocompatible hydrophobic domain, wherein said conjugate surrounds the core, wherein: the poorly hydrophilic compound comprises from about 20 mole % to about 99 mole % of the particle; the conjugate comprises from about 1 mole % to about 80 mole % of the particle; and the particle has a diameter of at least about 15 nm, wherein the particle is formed by an injection technique using a solvent that is miscible with water, wherein the injection technique comprises: (i) combining the poorly hydrophilic compound, the conjugate of the biocompatible hydrophilic domain and the biocompatible hydrophobic domain in a solvent that is miscible with water to form a mixture or solution, (ii) injecting the mixture or solution formed in (i) into an aqueous solution to form the particles, and (iii) collecting the particles.