Patent ID: 6114304
Filing Date: 2000-09-05
Classification: A61K,A61P,Y10S

Abstract:
A method of reducing gastric motility or delaying gastric emptying in a mammal comprising administering to said mammal a therapeutically effective amount of an amylin or an amylin agonist, wherein said amylin agonist is an amylin agonist analogue having the following amino acid sequence:.sup.1 A.sub.1 -X-Asn-Thr-.sup.5 Ala-Thr-Y-Ala-Thr-.sup.10 Gln-Arg-Leu-B.sub.1 -Asn-.sup.15 Phe-Leu-C.sub.1 -D.sub.1 -E.sub.1 -.sup.20 F.sub.1 -G.sub.1 -Asn-H.sub.1 -Gly-.sup.25 Pro-I.sub.1 -Leu-Pro-J.sub.1 -.sup.30 Thr-K.sub.1 -Val-Gly-Ser-.sup.35 Asn-Thr-Tyr-ZwhereinA.sub.1 is Lys, Ala, Ser or hydrogen;B.sub.1 is Ala, Ser or Thr;C.sub.1 is Val, Leu or Ile;D.sub.1 is His or Arg;E.sub.1 is Ser or Thr;F.sub.1 is Ser, Thr, Gln or Asn;G.sub.1 is Asn, Gln or His;H.sub.1 is Phe, Leu or Tyr;I.sub.1 is Ile, Val, Ala or Leu;J.sub.1 is Ser, Pro or Thr;K.sub.1 is Asn, Asp or Gln;X and Y are independently selected residues having side chains which are chemically bonded to each other to form an intramolecular linkage, wherein said intramolecular linkage comprises a disulfide bond, a lactam or a thioether linkage; and Z is amino, alkylamino, dialkylamino, cycloalkylamino, arylamino, aralkylamino, alkyloxy, aryloxy or aralkyloxy; and provided that when A.sub.1 is Lys, B.sub.1 is Ala, C.sub.1 is Val, D.sub.1 is Arg, E.sub.1 is Ser, F.sub.1 is Ser, G.sub.1 is Asn, H, is Leu, I.sub.1 is Val, J.sub.1 is Pro, and K.sub.1 is Asn; then one or more of A.sub.1 to K.sub.1 is a D-amino acid and Z is selected from the group consisting of alkylamino, dialkylamino, cycloalkylamino, arylamino, aralkylamino, alkyloxy, aryloxy or aralkyloxy.