Patent ID: 6090820
Filing Date: 2000-07-18
Classification: A61P,C07D

Abstract:
A compound of structural Formula I: or a pharmaceutically acceptable salt thereof wherein:R.sup.1 is (a) NR.sup.5,R.sup.2 is independently H or CH.sub.3 ;R.sup.3 is independently H, F, Cl or methoxy;R.sup.4 is (a) hydrogen,(b) C.sub.1 -C.sub.8 alkyl optionally substituted with one or more of the following: F, Cl, hydroxy, C.sub.1 -C.sub.8 alkoxy or C.sub.1 -C.sub.8 acyloxy,(c) C.sub.3 -C.sub.6 cycloalkyl,(d) amino,(e) C.sub.1 -C.sub.8 alkylamino,(f) C.sub.1 -C.sub.8 dialkylamino, or(g) C.sub.1 -C.sub.8 alkoxy;R.sup.5 is (a) H,(b) C.sub.1-6 alkyl optionally substituted with one or more of the following: Cl, F, CN, OH, C.sub.1-4 alkoxy, amino, hydroxylamino, alkoxylamino, C.sub.1-4 acyloxy, C.sub.1-4 alkylsulfenyl, C.sub.1-4 alkylsulfinyl, C.sub.1-4 alkylsulfonyl, aminosulfonyl, C.sub.1-4 alkylaminosulfonyl, C.sub.1-4 dialkylaminosulfonyl, 4-morpholinylsulfonyl, phenyl (optionally substituted with one or more of F, Cl, CN, OH, C.sub.1 -C.sub.4 alkoxy), 5-isoxazolyl, ethenyloxy or ethynyl,(c) C.sub.1-6 acyl optionally substituted with one or more of the following: Cl, F, OH, SH, C.sub.1-4 alkoxy, naphthalenoxy and phenoxy (optionally substituted with one or more of the following: Cl, F, OH, C.sub.1 -C.sub.4 alkoxy, amino, C.sub.1 -C.sub.4 acyl amino, C.sub.1 -C.sub.4 alkyl), amino, C.sub.1 -C.sub.4 acylamino, hydroxylamino, alkoxylamino, C.sub.1-4 acyloxy, phenyl, C.sub.1 -C.sub.4 alkylcarbonyl, C.sub.1 -C.sub.4 alkylamino, C.sub.1 -C.sub.4 dialkylamino, C.sub.1 -C.sub.4 hydroxyacyloxy, C.sub.1 -C.sub.4 alkylsulfenyl, phthalimido, maleimido or succinimido,(d) C.sub.1-6 alkylsulfonyl optionally substituted with one or more of the following: Cl, F, OH, C.sub.1-4 alkoxy, amino, hydroxylamino, alkoxylamino, C.sub.1-4 acyloxy or phenyl,(e) arylsulfonyl optionally substituted with one or more of the following:F, Cl, OCH.sub.3, OH or C.sub.1-4 alkyl,(f) C.sub.1-6 alkoxycarbonyl optionally substituted with one or more of the following: Cl, F, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy or phenyl,(g) aminocarbonyl, C.sub.1-6 alkylaminocarbonyl or C.sub.1-6 dialkylaminocarbonyl (where the alkyl groups are optionally substituted with one or more of the following: Cl, F, OH, C.sub.1-4 alkoxy or phenyl),(h) five- and six-membered heterocycle optionally substituted with one or more of the following: Cl, F, OH, amino or C.sub.1-4 acylamino, C.sub.1-4 alkylsulfonylamino, C.sub.1-4 alkoxycarbonylamino, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy or C.sub.1-4 alkyl which is optionally substituted with F, OH or C.sub.1-4 alkoxy,(i) C.sub.3 -C.sub.6 cycloalkylcarbonyl optionally substituted with one or more of the following: F, Cl, OH, C.sub.1 -C.sub.4 alkoxy or CN,(j) benzoyl optionally substituted with one or more of the following: F, Cl, OH, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl amino or C.sub.1 -C.sub.4 acylamino,(k) pyrrolylcarbonyl optionally substituted with one or more of C.sub.1 -C.sub.4 alkyl, or(l) C.sub.1 -C.sub.2 acyloxyacetyl where the acyl is optionally substituted with the following:amino, C.sub.1 -C.sub.4 alkylamino, C.sub.1 -C.sub.4 dialkylamino, 4-morpholino,4-aminophenyl, 4-(dialkylamino)phenyl or 4-(glycylamino)phenyl;R.sup.6 is (a) H,(b) OH,(c) C.sub.1-6 alkoxy,(d) amino, C.sub.1-6 alkylamino, C.sub.1-6 dialkylamino, hydroxylamino, or C.sub.1-2 alkoxylamino all of which is optionally substituted on the nitrogen with: C.sub.1-6 acyl (optionally substituted with one or two of Cl or OH), C.sub.1-6 alkylsulfonyl optionally substituted with one or two of Cl or OH), or C.sub.1-6 alkoxycarbonyl, or(e) Cl or F;R.sup.7 is (a) H,(b) C.sub.1-6 alkyl optionally substituted with one or more of the following: Cl, F, CN, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy or amino,(c) CN, or(d) phenyl optionally substituted with one or more of the following: Cl, F, OH or C.sub.1-4 alkoxy; orR.sup.6 and R.sup.7 taken together are (a) carbonyl or thiocarbonyl group,(b) ethylene ketal (--OCH.sub.2 CH.sub.2 O--), propylene ketal (--OCH.sub.2 CH.sub.2 CH.sub.2 O--), ethylene thioketal (--SCH.sub.2 CH.sub.2 S--), propylene thioketal (--SCH.sub.2 CH.sub.2 CH.sub.2 S--), dimethyl ketal, diethyl ketal, dimethyl thioketal or diethyl thioketal,(c) oxime optionally substituted with H, C.sub.1-6 alkyl (optionally substituted with Cl, F or C.sub.1-4 alkoxy), C.sub.1-6 acyl (optionally substituted with one or more of the following: Cl, F, OH, C.sub.1-4 alkoxy or C.sub.1-4 acyloxy),(d) hydrazone optionally substituted with H, C.sub.1-6 alkyl (optionally substituted with one or more Cl, F, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy, phenyl, C.sub.1-6 acyl (optionally substituted with one or more of Cl, F, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy, phenyl), C.sub.1-6 alkoxycarbonyl (optionally substituted with one or more of the following: Cl, F, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy or phenyl), or C.sub.1-6 alkylsulfonyl,(e) imine optionally substituted with H or a C.sub.1-6 alkyl (optionally substituted with Cl, F, OH, C.sub.1-4 alkoxy, C.sub.1-4 acyloxy, or phenyl), or(f) carbon-carbon double bond optionally substituted with H, C.sub.1-4 alkoxycarbonyl or C.sub.1-4 alkyl (optionally substiuted with Cl, F, OH, C.sub.1-4 alkoxy or phenyl);m is 0-2; n is 1-3; o is 0-3; and p is 1-3.