Patent ID: 6629969
Filing Date: 2003-10-07
Classification: A61L,A61M

Abstract:
A method for modifying an agent formulation prior to delivery to a subject, the method comprising:implanting at least a distal portion of a catheter at a delivery site in a subject, a catheter comprising: an elongate body comprising a proximal end defining an inlet, and a distal end defining an outlet, the elongate body defining a passageway extending between the proximal and distal ends; and a modifying element operatively associated with the elongate body such that at least an inner wall of the modifying element is in fluid communication with the elongate body passageway; wherein the modifying element comprises a modifying agent, wherein the modifying agent activates a previously inactive form of a drug or therapeutic agent; and introducing a flowable formulation comprising an inactive form of a drug or therapeutic agent into the inlet of the elongate body; wherein the introduced formulation flows through the elongate body passageway and contacts the inner wall of the modifying element, and wherein the inactive form of a drug or therapeutic agent is modified and activated by the modifying agent prior to release at the delivery site in the subject.