Patent ID: 8993533
Filing Date: 2015-03-31
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A method of upregulating a function of and/or the expression of a Sialidase 4 (NEU4) polynucleotide selected from SEQ ID No: 1 in a biological system comprising: contacting said system with at least one antisense oligonucleotide 10 to 30 nucleotides in length wherein said at least one oligonucleotide specifically hybridizes to a natural antisense polynucleotide of the Neu4 polynucleotide and has at least 80% sequence identity to a 10 to 30 nucleotide region of a reverse complement of a natural antisense polynucleotide of the Sialidase 4 (NEU4) polynucleotide selected from nucleotides 1 to 2119 of SEQ ID NO: 2 or 1245 of SEQ ID NO: 3 or 1 to 490 of SEQ ID NO: 4 or 1 to 527 of SEQ ID NO: 5 or 1 to 946 of SEQ ID NO: 6 or 1 to 703 of SEQ ID NO 7; thereby upregulating a function of and/or the expression of the Sialidase 4 (NEU4) polynucleotide.