Patent ID: 8852630
Filing Date: 2014-10-07
Classification: A61K,C07D,C07K

Abstract:
1. A method of treating prostate cancer in a patient in need thereof comprising administering to said patient an effective amount of a compound according to the chemical structure: wherein A is an antibody binding moiety according to the chemical formula: Y′ is H or NO X is O, CH R X′ is CH R Z is a bond, a monosaccharide, disaccharide, oligosaccharide, glycoprotein or glycolipid; X X″ is O, CH R n is 1 or 2; n B is a cell binding moiety according to the chemical formula: Where X X R k is an integer from 0 to 20; L is a linker according to the chemical formula: Or a polypropylene glycol or polypropylene-co-polyethylene glycol linker having between 1 and 100 glycol units; Where R R m is an integer from 1 to 45, or L is a linker according to the chemical formula: Where Z and Z′ are each independently a bond, —(CH wherein said —(CH Each R is independently H, or a C Each R Each Y is independently a bond, O, S or N—R; Each i is independently 0 to 100; D is or a bond, with the proviso that Z, Z′ and D are not each simultaneously bonds; j is 1 to 100; m′ is 1 to 100; n′ is 1 to 100; and X R is as defined above; and Where X X R a pharmaceutically acceptable salt thereof.