Patent ID: 9115179
Filing Date: 2015-08-25
Classification: C07K

Abstract:
1. A method of preparing a β-turn peptidomimetic cyclic compound of formula (I) the method comprising steps of: (a) providing a protected linear peptidomimetic compound of formula (III) (b) cyclizing the protected linear peptidomimetic compound of formula (III) to form a protected β-turn peptidomimetic cyclic compound of formula (IV) by an intramolecular aromatic nucleophilic substitution  and (c) deprotecting an amino acid side chain protecting group in the protected β-turn peptidomimetic cyclic compound of formula (IV); wherein: R R R Y is selected from the group consisting of hydrogen, —NO each R X is selected from the group consisting of O, N, S, P, Se, C, C1 to C6 alkylene, SO, SO Z is selected from the group consisting of F, Cl, Br and I; R W n is 0, 1, 2, 3, 4 or 5; and L