Patent ID: 7504101
Filing Date: 2009-03-17
Classification: A61K,A61P,C07K

Abstract:
1. A method of enhancing an immune response of a mammal to an antigen expressed by a tumor cell, comprising priming T cells in the mammal with the tumor antigen, wherein the priming comprises administering to the mammal a therapeutically effective amount of attenuated tumor cells, tumor cell membranes, or isolated tumor antigen; and administering to the mammal a therapeutically effective amount of a composition consisting essentially of a purified antibody that specifically binds OX-40 polypeptide or an immunologically effective fragment of the antibody that specifically binds OX-40 polypeptide and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the antibody that specifically binds OX-40 polypeptide or the immunologically effective fragment of the antibody is presented to T-cells of the mammal during or shortly after priming of the T-cells by the tumor antigen, thereby inducing the immune response, wherein the immune response is against the tumor cell.