Patent ID: 7247302
Filing Date: 2007-07-24
Classification: A61K,C07K

Abstract:
1. A method of inhibiting IgG immunoglobulin-induced toxicity in a subject, said toxicity resulting from immunotherapy for a disease or in vivo diagnosis of a disease comprising administering to said subject an IgG immunoglobulin that binds to a target antigen associated with said disease, said IgG immunoglobulin having a variable region and a constant region comprising the CH 2 domain of said IgG, wherein said IgG is modified prior to the administration by structurally altering multiple toxicity-associated regions in the CH 2 domain of said constant region so that said administration inhibits said toxicity in said subject, wherein said multiple toxicity-associated regions are localized to amino acids 231–238 and amino acids 310–331 of the CH 2 domain, wherein the numbering of said amino acids is according to the 1991 Kabat amino acid numbering system.