Patent ID: 9060963
Filing Date: 2015-06-23
Classification: A61K,A61P

Abstract:
1. A method of reducing inflammation of skin in need thereof comprising topically applying to said skin an effective amount of an anti-inflammatory mushroom hydrolsate, wherein said mushroom hydrolysate is substantially devoid of acid protease activity, and wherein the mushroom hydrolysate is obtained by: (a) extracting water-soluble polysaccharopeptide constituents of Coriolus versicolor with acidic aqueous solvent having a pH of from about 3.5 to about 4.5 to provide a water-soluble polysaccharopeptide extract; (b) hydrolyzing the water-soluble polysaccharopeptide extract with an acid protease enzyme of Rhizomucor miehei ; and (c) inactivating the acid protease with a molecular weight sieve, by thermal inactivation, or by pepstatin-affinity gel chromatography.