Patent ID: 7381720
Filing Date: 2008-06-03
Classification: A61P,C07D

Abstract:
1. A method for reducing cell proliferation or inducing cell death, comprising contacting a cell with an effective amount of the compound having formula 1, or pharmaceutically acceptable salts, and esters thereof; wherein V is H, halo, NR A is H, fluoro, or NR Z is O, S, NR U is selected from the group consisting of NR X is OR n is 1-6; wherein R R is an optionally substituted 5-14 membered heterocyclic ring containing one or more N, O or S; or a C R R R W is selected from the group consisting of wherein Q, Q Y is independently O, CH, C═O or NR and R wherein each optionally substituted moiety is substituted with one or more halo, OR thereby reducing cell proliferation or inducing cell death; wherein when said contacting is in vivo, said cell is a prostate cancer cell, a colorectal cancer cell, a cervical cancer cell, a leukemia cell, or a lymphoma cell.