Patent ID: 8507005
Filing Date: 2013-08-13
Classification: A61P,C07D,Y10T

Abstract:
1. Particulates of {4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)-benzyl)pyrimidin-5-yl}acetic acid of Formula I: in crystalline Form I; wherein the particulates have one or more characteristics, selected from the group consisting of: (i) having an average particle size ranging from about 0.1 to about 150 μm; (ii) having a uniformity coefficient ranging from about 1 to about 20; (iii) having a tapped bulk density ranging from about 0.1 to about 1.0 g/mL; (iv) containing no less than about 95% by weight of the acid of Formula I; (v) having a residual organic solvent content of no greater than about 5% by weight; (vi) having a residual methanol content of no greater than about 100,000 ppm; (vii) containing no less than about 90% by weight of the particulates in Form I; and wherein the particulates have a differential scanning calorimetric thermogram with an endotherm at a peak temperature of about 224° C. and an onset temperature of about 220° C.