Patent ID: 8647295
Filing Date: 2014-02-11
Classification: A61B

Abstract:
1. A method for accurately determining the rate of release of an agent dissolved in emulsion and/or microemulsion droplets, comprising: a) providing a probe comprising a section of relatively highly permeable membrane relative to any materials to which the membrane is attached for support and positioned between an inlet to a source of emulsion and an outlet to a receptacle, and through which membrane particles are to be transferred; b) putting said probe in contact with a medium into which the particles are to be transferred by diffusion; c) perfusing a known quantity (V d) allowing said known quantity of emulsion to remain stationary for a resting time (t e) flushing out said known quantity of emulsion with a single pulse of a known volume (V f) determining the concentration of said agent remaining in said known volume (V g) repeating steps (c) through (f) with at least one different (t h) plotting the results of steps (f) and (g) to determine how said concentration changes with (t i) taking the slope of the plot of step (h), which is the rate of release of said agent from the emulsion.