Patent ID: 6191140
Filing Date: 2001-02-20
Classification: A61P,C07C,C07D

Abstract:
A compound having formula I ##STR57##or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, whereinn is 0-1;m is 1-2;A is selected from the group consisting of NR.sub.2, O, and S;A' is selected from the group consisting of NR.sub.3, O, S and CR.sub.4 R.sub.5 ;D is selected from the group consisting of CH.sub.2 and C(O);D' is selected from the group consisting of CH.sub.2, C(O), S(O), and S(O).sub.2 ;R.sub.1 is selected from the group consisting of aryl and heterocycle;R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen, alkoxyalkyl, alkyl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocyclealkyl, hydroxy, hydroxyalkyl, --NZ.sub.1 Z.sub.2, and (NZ.sub.1 Z.sub.2)alkyl wherein A.sub.1 and Z.sub.2 are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl, and formyl;R.sub.4 and R.sub.5 are independently selected from the group consisting of hydrogen and alkyl;R.sub.6 and R.sub.7 are independently selected from the group consisting of hydrogen and alkyl;with the proviso that when D is CH.sub.2 then D' is other than CH.sub.2 ; andwith the proviso that when D' is S(O) or S(O).sub.2 then A' is CR.sub.4 R.sub.5.