Patent ID: 7771727
Filing Date: 2010-08-10
Classification: A61K,A61P

Abstract:
1. A compound represented by the following formula: wherein: X is camptothecin, homocamptothecin, colchicine, thiocolchicine, combretastatin, dolastatin, doxorubicin, methotrexate, podophyllotoxin, rhizoxin, rhizoxin D, a taxol, paclitaxel, CC1065, or a maytansinoid; n is an integer from 0 to 6, wherein (CH R is N(R wherein: Y is a hydrophilic spacer sequence selected from the group consisting of a peptide that increases the hydrophilic biodistribution of said compound and a hydrophilic polymer, or is omitted, wherein: Z is a linking peptide that is bonded to Q at the N-terminus or at a compatible side-chain amino group of Q or is omitted, wherein Z has the formula: A-B-C-E-F, wherein: provided that when A, B, C, and E are Tyr, Tyr, Lys, and Tyr, respectively, F is not Lys; and when A, B, C, and E are Lys, Tyr, Lys, and Tyr, respectively, F is not Tyr or Lys; and when A and B are deleted, and C and E are Lys and Tyr, respectively, F is not Tyr or Lys; and Q is a targeting moiety selected from a somatostatin peptide, a bombesin peptide, or a vasoactive intestinal peptide (VIP).