Patent ID: 6420367
Filing Date: 2002-07-16
Classification: A61P,C07D

Abstract:
A compound represented by the formula (I): wherein,R1, R2, R3 and R4 are each independently hydrogen atom, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, an optionally substituted non-aromatic heterocyclic group, or acyl; or R1 and R2, R3 and R4, and R2 and R3 each taken together with the adjacent nitrogen atom form the same or different 3- to 6-membered ring optionally containing O, S, or N, provided that R1 and R2, and R3 and R4 do not form a ring when R2 and R3 taken together form a ring; R5 and R6 are each independently hydrogen atom, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkyloxy, alkylthio, optionally substituted alkyloxycarbonyl, optionally substituted aryl, optionally substituted heteroaryl, halogen, hydroxy, mercapto, optionally substituted amino, carboxy, cyano, or nitro; X is â€”N(R7)â€”, â€”NHâ€”NHâ€”, â€”Oâ€”, or â€”Sâ€” wherein R7 is hydrogen atom or optionally substituted alkyl; Y is optionally substituted 5-membered non-aromatic heterocycle-diyl or optionally substituted 5-membered heteroaryl-diyl; Z is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl alkenyl, or optionally substituted alkenyl; an ester derivative thereof, an acyloxy derivative thereof or an amide derivative thereof, pharmaceutically acceptable salts thereof, or solvates thereof.