Patent ID: 9000141
Filing Date: 2015-04-07
Classification: A61K,A61P,C07K,C12N,G01N,Y02A

Abstract:
1. An isolated nucleic acid molecule encoding a mutant flavivirus E-glycoprotein polypeptide comprising at least one amino acid substitution at position 104 or 106 compared to a wild type flavivirus E-glycoprotein polypeptide, wherein the mutant E-glycoprotein polypeptide exhibits reduced antibody cross-reactivity as compared to the wild type E-glycoprotein polypeptide, and wherein the flavivirus is selected from the group consisting of dengue serotype 1 virus, dengue serotype 2 virus, dengue serotype 3 virus, dengue serotype 4 virus, St. Louis encephalitis virus, and West Nile virus.