Patent ID: 7662804
Filing Date: 2010-02-16
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: (±)-2-(3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yl)-propionic acid (Compound 101); 2-(5′-Chloro-3′-{N′-[1-(3,4-dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yl)-2-methyl-propionic acid (Compound 102); (±)-2-(3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yl)-3-phenylpropionic acid (Compound 103); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yl)-butyric acid (Compound 104); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-propionic acid (Compound 105); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-thiopropionic acid (Compound 106); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-5′-fluoro-2′-hydroxy-biphenyl-4-yl)-propionic acid (Compound 107); 3-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-biphenyl-2,3′-dicarboxylic acid (Compound 108); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-5′-methyl-biphenyl-4-yl)-propionic acid (Compound 109); 2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-2-methyl-propionic acid (Compound 110); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-hexanoic acid (Compound 111); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-3-methyl-butyric acid (Compound 112); (−)-2-(S)-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-propionic acid (Compound 113); (+)-2-(R)-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-propionic acid (Compound 114); (3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yloxy)-acetic acid (Compound 115); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-5′-fluoro-2′-hydroxy-biphenyl-3-yl)-propionic acid (Compound 116); (±)-{[2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]- hydrazino}-2′-hydroxy-biphenyl-4-yl)-propionyl]-methyl-amino} acetic acid (Compound 117); (±)-{[2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-propionyl]-methyl-amino}-acetic acid ethyl ester (Compound 118); (±)-4-({5-Chloro-2-hydroxy-4′-[1-(1H-tetrazol-5-yl)-ethyl]-biphenyl-3-yl}-hydrazono)-2-(3,4-dimethyl-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one (Compound 119); (±)-2-(3,4-Dimethyl-phenyl)-4-({2-hydroxy-4′-[1-(1H-tetrazol-5-yl)-ethyl]-biphenyl-3-yl}-hydrazino)-5-methyl-2,4-dihydro-pyrazol-3-one (Compound 120); (±)-2-(2′-Hydroxy-3′-{N′-[3-methyl-5-oxo-1-(4-propyl-phenyl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-biphenyl-4-yl)-propionic acid (Compound 121); 3-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo -1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-fluoro-biphenyl-3-carboxylic acid (Compound 122); 2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-5′-methyl-biphenyl-3-yloxy)-2-methyl-propionic acid (Compound 123); [(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-carbonyl)-amino]-acetic acid (Compound 124); [(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-carbonyl)-amino]-acetic acid ethyl ester (Compound 125); (±)-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo -1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-methoxy-acetic acid (Compound 126); (±)-2-(5′-Chloro-3′-{N′-[1-(3,4-dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yloxy)-butyric acid (Compound 127); 3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-methoxy-biphenyl-3-carboxylic acid (Compound 128); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yl)-butyric acid (Compound 129); (±)-2-(3′-{N′-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-4-yloxy)-propionic acid (Compound 130); 2-(5′-Chloro-3′-{N′-[1-(3,5-dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-2′-hydroxy-biphenyl-3-yl)-2-methyl-propionic acid (Compound 131); or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof.