Patent ID: 6057446
Filing Date: 2000-05-02
Classification: A61K

Abstract:
A compound having the formula: ##STR3## wherein X' is nitrogen and X is carbon or carbon bonded to a substituent selected from the group consisting of H, F, Cl, Br, I, R', NR'R"", CF.sub.3, OH, CN, NO.sub.2, C.sub.2 R', SH, SCH.sub.3, N.sub.3, SO.sub.2 CH.sub.3, OR', SR', C(.dbd.O)NR'R"", NR'C(.dbd.O)R', C(.dbd.O)R', C(.dbd.O)OR', (CH.sub.2).sub.q OR', OC(.dbd.O)R', OC(.dbd.O)NR'R"", and NR'C(.dbd.O) OR', where R' and R"" are individually hydrogen C.sub.1 -C.sub.10 alkyl, an aromatic group, and q is an integer from 1 to 6; A, A' and A"" are the same as X; Z' is a substituent selected from the group consisting of alkyl, aryl, aralkyl, halo, hydroxyl, alkoxyl, alkylhydroxy, cyano, and mercapto; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Z"" is hydrogen or a substituent other than hydrogen; Y is C.dbd.O, C(OH)R' or C--A, where R' is hydrogen or lower alkyl.