Patent ID: 9066984
Filing Date: 2015-06-30
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated antibody or antigen-binding fragment thereof that specifically binds to Sp35, wherein the antibody or the antigen-binding fragment thereof comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein (i) the VH comprises the amino acids of SEQ ID NO:372 and the VL comprises the amino acids of SEQ ID NO:373; or (ii)the VH comprises CDR1, CDR2, and CDR3 regions comprising the amino acids of SEQ ID NOs: 389, 390, and 391, respectively and the VL comprises CDR1, CDR2, and CDR3 regions comprising the amino acids of SEQ ID NO:s: 386, 387, and 388, respectively.