Patent ID: 6500980
Filing Date: 2002-12-31
Classification: C07C

Abstract:
A process for preparing an amino derivative of a Câ€”H-acid compound represented by formula I: whereinR is an unbranched or branched alkyl group having from 1 to 10 carbon atoms, a cycloaliphatic radical having from 5 to 12 carbon atoms, an aryl radical, an alkylaryl radical having a total of from 7 to 12 carbon atoms, or an aralkyl radical having a total of from 7 to 12 carbon atoms, and X1 and X2 are identical or different electron-withdrawing groups, comprising: reacting a Câ€”H-acid compound represented by formula II: wherein R, X1, and X2 are as defined above, with nitrous acid liberated from a nitrite by an inorganic or organic acid, in the presence of from 1 to 10 equivalents of a carboxylic anhydride to produce an O-acyl derivative of the nitrosation product of the Câ€”H-acid compound represented by formula II, and then hydrogenating the O-acyl derivative of the nitrosation product of the Câ€”H-acid compound represented by formula II in the presence of a hydrogenation catalyst, wherein the reaction mixture is substantially free of water.