Patent ID: 8999950
Filing Date: 2015-04-07
Classification: A61K,A61P,C07H,C12N,C12Y

Abstract:
1. A composition comprising an interfering RNA that silences aldehyde dehydrogenase (ALDH) gene expression, wherein the interfering RNA comprises a sense strand and a complementary antisense strand, and wherein the interfering RNA comprises a double-stranded region of about 15 to about 60 nucleotides in length, wherein the interfering RNA is selected from the group consisting of siRNA Identifier 1 (SEQ ID NOs:11 & 12), siRNA Identifier 2 (SEQ ID NOs:13 & 12), siRNA Identifier 3 (SEQ ID NOs:14 & 15), siRNA Identifier 4 (SEQ ID NOs:16 & 15), siRNA Identifier 5 (SEQ ID NOs:17 & 18) and siRNA Identifier 6 (SEQ ID NOs:19 & 18).