Patent ID: 7407963
Filing Date: 2008-08-05
Classification: A61P,C07D

Abstract:
1. A compound of general formula (I) wherein: R is a saturated or mono- or diunsaturated 5- to 7-membered aza, diaza, triaza, oxaza, thiaza, thiadiaza, or S,S-dioxido-thiadiaza heterocyclic group linked via a carbon or nitrogen atom, and wherein the heterocyclic group of R: wherein an olefinic double bond thereof is optionally fused with a benzene, pyridine, diazine, 1,3-oxazole, thiophene, furan, thiazole, pyrrole, N-methylpyrrole, quinoline, imidazole, or N-methylimidazole ring, and wherein the phenyl, pyridinyl, diazinyl, furyl, thienyl, pyrrolyl, 1,3-oxazolyl, 1,3-thiazolyl, isoxazolyl, pyrazolyl, 1-methylpyrazolyl, imidazolyl, or 1-methylimidazolyl groups contained in R and the benzo, thieno, pyrido- and diazino-fused heterocyclic groups in R are optionally independently additionally mono-, di-, or trisubstituted by: wherein multiple substitution of the aforementioned phenyl, pyridinyl, diazinyl, furyl, thienyl, pyrrolyl, 1,3-oxazolyl, 1,3-thiazolyl, isoxazolyl, pyrazolyl, 1-methylpyrazolyl, imidazolyl, or 1-methylimidazolyl groups contained in R and the benzo, thieno, pyrido- and diazino-fused heterocyclic groups in R by phenyl, C R wherein each group of R wherein the hydroxy, amino, indolyl and imidazolyl groups contained in the abovementioned groups are each optionally independently substituted by a protecting group selected from: (a) a phenylalkoxycarbonyl group with 1 to 3 carbon atoms in the alkoxy moiety optionally substituted in the phenyl nucleus by a halogen atom, a nitro or phenyl group, or one or two methoxy groups, (b) an alkoxycarbonyl group having a total of 1 to 5 carbon atoms in the alkyl moiety, or (c) a formyl, acetyl, trifluoroacetyl, allyloxycarbonyl, 2,2,2-trichloro-(1,1-dimethylethoxy)carbonyl, or 9-fluorenylmethoxycarbonyl group, wherein all the abovementioned alkyl and alkoxy groups and the alkyl or alkylene moieties present within the other groups specified contain 1 to 5 carbon atoms, unless otherwise stated, or a diastereomer, enantiomer, or salt thereof.