Patent ID: 8937287
Filing Date: 2015-01-20
Classification: G01N

Abstract:
1. A system to test the radiochemical purity of a sample radiopharmaceutical solution, comprising: a high performance liquid chromatography column to receive the sample radiopharmaceutical solution and to separate molecularly distinct species within the sample radiopharmaceutical solution into a number of separated molecularly distinct species; a radiation detector, said radiation detector measuring the radioactivity of the sample radiopharmaceutical solution before the sample radiopharmaceutical solution is received by said high performance liquid chromatography column, said radiation detector measuring the radioactivity of each separated molecularly distinct species from said high performance liquid chromatography column; and a computer to operate a program to calculate a decay-corrected radioactivity measurement for each separated molecularly distinct species using the measurement of the radioactivity of each separated molecularly distinct species from said high performance liquid chromatography column, the half-life of a selected radioactive isotope within the radiopharmaceutical solution, and the time elapsed between measuring the radioactivity of the sample radiopharmaceutical solution before the sample radiopharmaceutical solution is received by said high performance liquid chromatography column and measuring the radioactivity of each separated molecularly distinct species from said high performance liquid chromatography column, whereby the radiochemical purity of the sample radiopharmaceutical solution is calculated by comparing the decay-corrected radioactivity measurements of the separated molecularly distinct species to the radioactivity measurement of the sample radiopharmaceutical solution.