Patent ID: 6433228
Filing Date: 2002-08-13
Classification: C07C

Abstract:
Process for preparing 2-halogenoindan-1-ones of the formula (I) whereinx represents a member selected from the group consisting of hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxy and Hal represents chlorine or bromine, wherein an aniline of the formula whereinX is as defined under formula (I) is converted into the corresponding diazonium salt of the formula (III) whereinX and Hal are as defined under formula (I), and this salt is reacted with an acrylic compound of the formula (IV) whereinY represents COR wherein R is OH, Cl, Br, OC1-C4-alkyl or CN, thus giving a compound of the formula (V) whereinX and Hal are as defined under formula (I) and Y is as defined under formula (IV), and compounds of the formula (V) are then converted into compounds of the formula (V)â€²whereinX and Hal are as defined under formula (I) and Yâ€² represents COOH, COCl or COBr, and a compound of the formula (V)â€² is cyclized to a 2-halogenoindan-1-one of the formula (I).