Patent ID: 6809199
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound represented by (I): or a pharmaceutically acceptable salt thereof, whereinNon-Ar-Cyc is A is, O, CH2, or CH; B is â€”C1-6alkyl-, â€”C0-3alkyl-Oâ€”C0-3alkyl-, â€”C0-3alkyl-NHâ€”C0-3alkyl-, â€”C0-3alkyl-NHâ€”C3-7cycloalkyl-, â€”C0-3alkyl-N(C0-3alkyl)-C(O)â€”C0-3alkyl-, â€”C0-3alkyl-NHâ€”SO2â€”C0-3alkyl-, â€”C0-3alkyl-, â€”C0-3alkyl-Sâ€”C0-3alkyl-, C0-3alkyl-SO2â€”C0-3alkyl-, â€”C0-3alkyl-PHâ€”C0-3alkyl-, â€”C0-3alkyl-C(O)â€”C0-3alkyl, or a direct bond; D is CH, CH2, N, or NH; optionally A and D are bridged by â€”C1-4alkyl- to form a fused bicyclo ring with A and D at the bicyclo cusps; E1 is CH, N, or CR6; or B and E1 form â€”CH&boxH;CE2 is CH2, CHR, C(OH)R NH, NR, O, S, â€”S(O)â€”, or â€”S(O)2â€”; G1 is N, CH, or C(C1-3alkyl); G2 is N, CH, or C(C1-3alkyl) R, R7 and R77 each independently is hydrogen, C1-6alkyl-group, C2-6alkenyl-group, C4-6cycloalkyl-C0-6alkyl-group, N(C0-4alkyl)(C0-4alkyl)-C1-4alkyl-N(C0-4alkyl)-group, â€”N(C0-4alkyl)(C0-4alkyl) group, C1-3alkyl-COâ€”C0-4alkyl-group, C0-6alkyl-Oâ€”C(O)â€”C0-4alkyl-group, C0-6alkyl-C(O)â€”Oâ€”C0-4alkyl-group, N(C0-4alkyl) (C0-4alkyl)-(C0-4alkyl)C(O)(C0-4alkyl)-group, phenyl-C0-4alkyl-group, pyridyl-C0-4alkyl-group, pyrimidinyl-C0-4alkyl-group, pyrazinyl-C0-4alkyl-group, thiophenyl-C0-4alkyl-group, pyrazolyl-C0-4alkyl-group, imidazolyl-C0-4alkyl-group, triazolyl-C0-4alkyl-group, azetidinyl-C0-4alkyl-group, pyrrolidinyl-C0-4alkyl-group, isoquinolinyl-C0-4alkyl-group, indanyl-C0-4alkyl-group, benzothiazolyl-C0-4alkyl-group, any of the groups optionally substituted with 1-6 substituents, each substituent independently being â€”OH, â€”N(C0-4alkyl)(C0-4alkyl), C1-4alkyl, C1-6alkoxyl, C1-6alkyl-COâ€”C0-4alkyl-, pyrrolidinyl-C0-4alkyl-, or halogen; or R7 together with a bond from an absent ring hydrogen is &boxH;O; nâ€²+nâ€³=n; mâ€²+mâ€³=m; n is 1, 2, 3, or 4; m is 0, 1, 2, 3, or 4; n+m is 2, 3, 4, 5, or 6; p is 0, 1, 2, or 3; R1, R2, R3, R4, and R6 are each independently halogen, C0-4alkyl, â€”C(O)â€”O(C0-4alkyl), or â€”C(O)â€”N(C0-4alkyl)(C0-4alkyl), R5 and R55 independently is H, CH3, CH2CH3, or absent; R88 and R8 each is independently â€”CN, â€”C0-4alkyl, â€”C(O)â€”N(C0-4alkyl)(C0-4alkyl), â€”C(O)â€”Oâ€”C0-4alkyl or 1,3dioxolan-2-yl-C0-4alkyl-; R9 is â€”C0-4alkyl, or absent; and any alkyl optionally substituted with 1-6 independent halogen or â€”OH.