Patent ID: 6300500
Filing Date: 2001-10-09
Classification: C07D

Abstract:
A process for preparing an aminopyridone derivative of the formula (5): ##STR132##wherein R.sup.1 is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, a cycloalkyl group, or a substituted cycloalkyl group; Y.sup.1 is a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, or a substituted aromatic group; and Y.sup.2 and Y.sup.3 are independently a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, a trifluoromethyl group, a nitro group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfinyl group, a lower aikylsulfonyl group, an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, a substituted aromatic group, or Y.sup.2 and Y.sup.1 may combine each other together with the carbon atoms to which they bond, and form a substituted or unsubstituted pyridine ring, which comprises heating a compound of the formula (8): ##STR133##wherein R.sup.1, Y.sup.1, Y.sup.2 and Y.sup.3 are as defined above, and Ring B is a substituted or unsubstituted benzene ring, in the presence of a base, to give a compound of the formula (9): ##STR134##wherein R.sup.1, Y.sup.1, Y.sup.2, Y.sup.3 and Ring B are as defined above, followed by removing the protecting phthaloyl group thereof.