Patent ID: 6743807
Filing Date: 2004-06-01
Classification: A61P,C07C,C07D

Abstract:
A compound of formula II: or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein;A is selected from-CONHOH, â€”CONHOR5, â€”CONHOR6, â€”N(OH)COR5, and â€”N(OH)CHO; ring B is tetrahydropyranyl or pyrrolidinyl; Z is a C3-13 carbocycle substituted with 0-5 Rb; Ua is absent or is O; Xa is absent or is C1-10 alkylene; Ya is absent; Za is quinolinyl substituted with 0-5 Rc; R1 is selected from H, C1-4 alkyl, phenyl, and benzyl; R2 is selected from H, C1-10 alkylene-Q substituted with 0-3 Rb1 , C2-10 alkenylene-Q substituted with 0-3 Rb1, and C2-10 alkynylene-Q substituted with 0-3 Rb1; Q is selected from H and a C3-13 carbocycle substituted with 0-5 Rd; Ra, at each occurrence, is independently selected from H, C1-4 alkyl, phenyl and benzyl; Ra1, at each occurrence, is independently selected from H and C1-4alkyl; Ra2, at each occurrence, is independently selected from C1-4alkyl, phenyl and benzyl; Rb, at each occurrence, is independently selected from C1-6 alkyl, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, Rb1, at each occurrence, is independently selected from ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, and NRaRa1, Rc is C1-6 alkyl; Rd, at each occurrence, is independently selected from C1-6alkyl, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)O, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CF2CF3, and C3-10 carbocycle; R5, at each occurrence, is selected from C1-10 alkyl substituted with 0-2 Rb, and C1-8 alkyl substituted with 0-2 Re; Re, at each occurrence, is selected from phenyl substituted with 0-2 Rb and biphenyl substituted with 0-2 Rb; R6, at each occurrence, is selected from phenyl, naphthyl, C1-10 alkyl-phenyl-C1-6 alkyl-, C3-11 cycloalkyl, C1-6 alkylcarbonyloxy-C1-3 alkyl-, C1-6alkoxycarbonyloxy-C1-3 alkyl-, C2-10 alkoxycarboonyl, C3-6 cycloalkylcarbonyloxy-C1-3 alkyl-, C3-6cycloalkoxycarbonyloxy-C1-3 alkyl-, C3-6cycloaclkoxycarbonyl, phenoxycarbonyl, phenyloxycarbonyloxy-C1-3 alkyl-, phenylcarbonyloxy-C1-3 alkyl-, C1-6 alkoxy-C1-6 alkylcarbonyloxy-C1-3 alkyl-, {5-(C1-C5 alkyl)-1,3-dioxa-cyclopenten-2-one-yl}methyl, {5-(Ra)-1,3-dioxa-cyclopenten-2-one-yl}methyl, (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyl, â€”C1-10 alkyl-NR7R7a, â€”CH(R8)OC(&boxH;O)R9, and â€”CH(R8)OC(&boxH;O)OR9; R7 is selected from H and C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-; R7a is selected from H and C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-; R8 is selected from H and C1-4 linear alkyl; R9 is selected from H, C1-8 alkyl substituted with 1-3 Rf, C3-8 cycloalkyl substituted with 1-2 Rf, and phenyl substituted with 0-2 Rb; Rf, at each occurrence, is elected from C1-4 alkyl, C3-8 cycloalkyl, C1-5 alkoxy, and phenyl substituted with 0-2 Rb; and, p, at each occurrence, is selected from 0, 1, and 2.