Patent ID: 6605194
Filing Date: 2003-08-12
Classification: C07D

Abstract:
A method of preparing a calix(4) pyrrole, said method comprising:(a) refluxing a pyrrole with an acyclic or cyclic ketone in the presence of a molecular sieve catalyst in an organic solvent at a temperature of about 100Â° C. for a period of between about 10 to about 72 hours; (b) cooling the reaction mixture of step (a) to room temperature; (c) filtering the solution of step (b) and washing the residue with an organic solvent to recover catalyst and to obtain a mother liquor; (d) evaporating to dryness the mother liquor of step (c) to obtain a solid; (e) washing the solid of step (d) with deionized water; (f) drying the washed solid of step (e) in air, followed by calcining at 373Â° K in air; and (g) purifying the calcined product of step (f) by column chromatography to obtain the calix (4) pyrrole.