Patent ID: 7749981
Filing Date: 2010-07-06
Classification: A61F,A61K

Abstract:
1. A drug-eluting stent, wherein the stent is coated with one or more non-nucleotide P2Y12 receptor antagonist compound of general Formula I, or a pharmaceutically acceptable salt thereof, wherein a therapeutically effective amount of the compound is eluted to the local environment when the stent is placed in a vessel, wherein R a and R b are each independently selected from the group consisting of: hydrogen, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkynyl, C 3-7 cycloalkyl, C 4-7 cycloalkenyl, aralkyl, aryl, and saturated or unsaturated C 3-6 heterocycle; where all rings or chains optionally bear one or more substituents selected from the group consisting of alkyl, aryl, halogen, aralkyl, carboxy, alkoxycarbonyl, hydroxyl, acyloxy, alkoxy, aryloxy, and aralkoxy; or R R where R is selected from the group consisting of: C G=O, S, or NR R R R R R when R J=N or C, with the proviso that when J=N, then R when J=C, R when R D is O, NH, N-acyl, N-alkyl, or C; A and B are each independently selected from the group consisting of: C, N, substituted N, O, S, S(O), SO A and/or B are absent; X is a group as provided in Formula II: wherein: