Patent ID: 9114149
Filing Date: 2015-08-25
Classification: A61K,A61P

Abstract:
1. A method for the treatment of at least a solid tumor and/or refractory solid tumor selected from the group consisting of pancreas, bone, brain and stomach tumors in humans by means of the administration at an effective dose of a Cu(I) complex of the type [Cu(thp) 4 ] n [X] −n wherein thp is a tris(hydroxymethyl)phosphine and X comprises N 3 (azide), PF 6 , NO 3 , NO 2 , ClO 4 , Cl, Br, I, C 6 H 11 (CH 2 ) 3 CO 2 (cyclohexanebutyrate), D-gluconate, CH 3 COO, CF 3 COO, HCOO, C 5 HF 6 O 2 (hexafluoroacetylacetonate), C 5 H 4 F 3 O 2 (trifluoroacetylacetonate), BF 4 , CF 3 SO 3 , BH 4 , HBpz 3 (pyrazolylborates), HBtz 3 (triazolyborates), CH 3 (CH 2 ) 11 OSO 3 (dodecylsulfate), C 4 H 9 (C 2 H 5 )CHCOO (2-ethylhexanoate), B(C 2 H 5 ) 4 (tetraethylborate), C 17 H 35 COO (stearate), B(C 6 H 5 ) 4 (tetraphenylborate), BH(CH 3 COO) 3 (triacetoxyborohydride), CB 11 H 6 Br 6 (hexabromocarborane), C 10 H 19 O 3 (neodecanoate), SCN (thiocyanate), C 11 H 19 O 2 (TMHD) for n=1, X comprises PO 3 F (fluorophosphate), SiF 6 (hexafluorosilicate), C 2 O 4 (oxalate), SeO 3 (selenite), S (sulfide), SO 3 (sulfite), B 4 O 7 , SiO 3 (metasilicate), HPO 4 , CO 3 , SO 4 for n=2, X comprises PO 4 for n=3 and X comprises SiO 4 (orthosilicate) for n=4.