Patent ID: 7618613
Filing Date: 2009-11-17
Classification: A61K,A61P,G01N

Abstract:
1. A method for radiolabeling a chelator-conjugated antibody or antibody fragment with a therapeutic radioisotope for administration to a patient comprising (i) mixing the chelator-conjugated antibody or antibody fragment with a solution comprising the therapeutic radioisotope or salt thereof; and (ii) incubating the mixture for a time between about 2 and 10 minutes under amiable conditions such that a radiolabeled antibody or antibody fragment is produced having sufficient radioincorporation, immunoreactivity of at least 50% and a specific activity of about 5 mCi/mg to about 20 mCi/mg, without further purification of the radiolabeled antibody or antibody fragment from unincorporated radioisotope.