Patent ID: 8119362
Filing Date: 2012-02-21
Classification: G01N

Abstract:
1. A screening method for identifying candidate molecules that might be used for the treatment of respiratory conditions in humans due to a dysfunction in the central nervous system, wherein said screening method comprises a first in vitro step which determines whether the functional activity of a TASK-2 polypeptide in the presence of a test molecule is decreased or eliminated compared with the functional activity of said TASK-2 polypeptide in the absence of said test molecule, and a second in vivo step, wherein a test molecule that decreases or eliminates said functional activity in the first in vitro step is administered to non-human animal model presenting a respiratory disorder, wherein a molecule that reduces the presentation of the respiratory disorder in the animal model is a candidate molecule for the treatment of respiratory conditions in humans due to a dysfunction in the central nervous system.