Patent ID: 9023882
Filing Date: 2015-05-05
Classification: A61K,A61P,C07D

Abstract:
1. A 5-membered heterocyclic derivative represented by the general formula (I): wherein T represents nitro, cyano or trifluoromethyl; ring J represents a phenyl ring or a 5 or 6-membered heteroaryl ring; Q represents carboxy, lower alkoxycarbonyl, carbamoyl, mono(di)(lower alkyl)carbamoyl, sulfo, sulfamoyl or 5-tetrazolyl when ring J represents a phenyl ring; or Q represents carboxy, lower alkoxycarbonyl, carbamoyl, mono(di)(lower alkyl) carbamoyl or 5-tetrazolyl when ring J represents a 5 or 6-membered heteroaryl ring; X R Y represents hydroxy, amino, a halogen atom, perfluoro(lower alkyl), optionally substituted lower alkyl, optionally substituted lower alkoxy, nitro, (lower alkyl)carbonylamino or (lower alkyl)sulfonylamino when ring J represents a phenyl ring; or Y represents a hydrogen atom, hydroxy, amino, a halogen atom, perfluoro(lower alkyl), optionally substituted lower alkyl, optionally substituted lower alkoxy, nitro, (lower alkyl)carbonylamino or (lower alkyl) sulfonylamino when ring J represents a 5 or 6-membered heteroaryl ring with the proviso that two or more Y optionally exist on ring J and these Y are optionally the same or different from each other; R A A represents a single bond, —O—, —S—, —CO—, —COO—, —CON(R D represents optionally substituted lower alkylene, optionally substituted lower alkenylene, optionally substituted lower alkynylene, optionally substituted C E represents a single bond, —O—, —S—, —CO—, —COO—, —CON(R G represents optionally substituted lower alkylene, optionally substituted lower alkenylene, optionally substituted lower alkynylene, optionally substituted C L represents a single bond, —O—, —S—, —CO—, —COO—, —CON(R M represents a hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted C