Patent ID: 8299054
Filing Date: 2012-10-30
Classification: A61P,C07B,C07C,C07D

Abstract:
1. A compound of formula (I) enantiomers, diastereomers, solvates, or salts thereof wherein: A is a 5- to 20-membered non-aromatic bi-, tri- or polycyclic ring system optionally containing 1-3 heteroatoms selected from N, O, S, S(O) and S(O) X is —C(═O)OH, —C(═O)C(═O)OH, —C(═O)NR W is absent, (—CR M is 1-3; Z is C provided that W and Z, or when W is absent, X and Z, are attached to the same carbon on Ring A; R R R R R R R two R R R R R R R provided that: (i) when W is absent, Z is phenyl, X is —C(═O)OH, lower alkyl or tetrazolyl, A is not bicyclo(2,2,1)heptanyl, bicyclo(2,2,1)heptenyl, bicyclo(2,2,2)octanyl, or bicyclo(2,2,2)octenyl; (ii) when W is absent, Z is optionally substituted phenyl, or heterocyclyl, X is —C(═O)OH or —C(═O)NR (iii) the compound is not a compound of the following structure: wherein R is optionally substituted phenyl; (iv) the compound is not a compound of the following structure: (v) the compound is not a compound of the following structure: (vi) the compound is not a compound of the following structure:  and (vii) when Z is optionally substituted C  which is substituted with at least one R  which may be optionally substituted with one or more R