Patent ID: 6232340
Filing Date: 2001-05-15
Classification: A61K,C07F

Abstract:
A vanadium(V) complex and pharmaceutically acceptable salts thereof, of the formula: ##STR11##wherein,Z.sub.1 is independently selected from O and NR.sub.4 ;Z.sub.2 is independently selected from O and NR.sub.5 ;Z.sub.3 is independently selected from O, NR, and C(R.sub.7).sub.2 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each independently selected from C.sub.1 -C.sub.10 alkyl, substituted C.sub.1 -C.sub.10 alkyl, C.sub.7 -C.sub.15 aralkyl, substituted C.sub.7 -C.sub.15 aralkyl, C.sub.7 -C.sub.15 alkylaryl, substituted C.sub.7 -C.sub.15 alkylaryl, C.sub.6 -C.sub.10 aryl, substituted C.sub.6 -C.sub.10 aryl and H, provided that R.sub.3 is not methyl; and independently R.sub.1 and R.sub.2, or R.sub.1 and R.sub.4, may together form a C.sub.7 -C.sub.15 alkylaryl, substituted C.sub.7 -C.sub.15 alkylaryl, C.sub.6 -C.sub.10 aryl, and substituted C.sub.6 -C.sub.10 aryl, wherein a substituted alkyl, aralkyl, alkylaryl or aryl contains at least one substituent selected from hydroxyl and halide;A is selected from --OH, .dbd.O and ##STR12##wherein Z.sub.1, Z.sub.2, Z.sub.3, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each defined as above; anda ring which includes Z.sub.3 also contains two normalized bonds.