Patent ID: 7115585
Filing Date: 2006-10-03
Classification: A61K,A61P,C07H

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein A is a covalently bound substituent having a maximum molecular weight of 1000 and is OR X T m=0, 1, or 2; n=0 or 1; p=0, 1, or 2; where the sum of m+n+p is from 0 to 5; M=H or a pharmaceutically-acceptable inorganic or organic counter ion; D=O or CH B is a purine or a pyrimidine residue according to general Formulae IV and V which is linked to the 1′ position of the furanose or carbocycle via the 9- or 1- position of the base, respectively; Y=H, OH, or OR Z=H, OH, or OR R wherein: O is the corresponding 2′ and/or 3′ oxygen of the furanose or carbocycle; C is the carbon atom; R R R R R R wherein: O is the 2′ and 3′ oxygens of the furanose or carbocycle; and the 2′ and 3′ oxygens of the furanose or carbocycle are linked by a common carbon atom to form a cyclical acetal, cyclical ketal, or cyclical orthoester; for cyclical acetals and ketals, R wherein: R R when R R when R J is carbon or nitrogen, with the provision that when nitrogen, R R R R R R