Patent ID: 8394803
Filing Date: 2013-03-12
Classification: A61P,C07D

Abstract:
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is selected from nitrogen or C—R X is selected from nitrogen or C—R R T is (CH y is 0, 1, or 2; Ar (a) a 3-8 membered saturated or partially unsaturated ring; (b) a 5-6 membered aryl ring; (c) a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; (d) a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (e) an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein Ar each occurrence of R each occurrence of R R any two R L is C R R any two R R R each occurrence of R′ is independently hydrogen, C two occurrences of R R R wherein any nitrogen atom in any of said rings is optionally substituted with —R R R R each R Ar wherein Ar two substituents on adjacent positions of Ar wherein any nitrogen atom in any of said rings is optionally substituted with —R R provided that the following compounds are excluded: 1-ethyl-3-(5-(2,3-dihydro-1-isopropyl-2-oxo-1H-imidazol-4-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea; and 1-ethyl-3-(5-(1,1-dimethylurea)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea.