Patent ID: 6046171
Filing Date: 2000-04-04
Classification: C07H

Abstract:
A compound selected from the group consisting of: ##STR15## wherein m is 0, 1, 2, 3, 4, 5, 6 or 7;n is 0, 1, 2, 3 or 4;R.sup.p is independently hydrogen or a hydroxy protecting group at each occurrence;A is absent or is selected from the group consisting of(1) --O--, and(2) --N(R.sup.1)--, wherein R.sup.1 is hydrogen or C.sub.1 -C.sub.6 -alkyl optionally substituted with aryl or heteroaryl;B is absent or is selected from the group consisting of(1) --(CH.sub.2).sub.q --, wherein q is 0, 1, 2, 3, 4, 5, or 6,(2) --C(O)--(CH.sub.2).sub.q --,(3) --C(O)--O--(CH.sub.2).sub.q --,(4) --C(O)--NR.sup.1 --(CH.sub.2).sub.q --, wherein R.sup.1 is as defined previously, and(5) --N.dbd.CH--(CH.sub.2).sub.q --;(6) --CH(OH)--(CH.sub.2).sub.q --, and(7) --CH(OH)--CH(OH)--(CH.sub.2).sub.q --;D is absent or is selected from the group consisting of(1) alkenylene,(2) arylene,(3) substituted arylene,(4) heteroarylene,(5) substituted heteroarylene;(6) alkenylene-arylene,(7) arylene-arylene,(8) substituted arylene-arylene,(9) heteroarylene-arylene,(10) substituted heteroarylene-arylene,(11) alkenylene-heteroarylene,(12) arylene-heteroarylene,(13) substituted arylene-heteroarylene,(14) heteroarylene-heteroarylene, and(15) substituted heteroarylene-heteroarylene;E is absent or is selected from the group consisting of(1) --(CH.sub.2).sub.r --CH.dbd.CH--,(2) --(CH.sub.2).sub.r --O--, wherein r is 0, 1, 2, 3 or 4,(3) --(CH.sub.2).sub.r --NR.sup.1 --CH.sub.2 --CH(OH)--, wherein R.sup.1 is as defined previously,(4) --(CH.sub.2).sub.r --C(O)--O--,(5) --(CH.sub.2).sub.r --N(R.sup.1)--,(6) --(CH.sub.2).sub.r --O--C(O)--,(7) --(CH.sub.2).sub.r --C(O)--N(R.sup.1)-- and(8) --(CH.sub.2).sub.r --N(R.sup.1)--C(O)--,with the restrictions that the sum of m +q may not be 0, that the sum of m+n+q+r is an integer from 2 to 7, that when the A and B moieties are both absent then m cannot be 0, that when E is --CH.dbd.CH-- and the A, B and D moieties are all absent then m cannot be 0, and that B can be --N.dbd.CH--(CH.sub.2).sub.q -- only when A is absent and m is 0.