Patent ID: 6262265
Filing Date: 2001-07-17
Classification: C07D,C07F,G01N

Abstract:
A compound having the following structure: ##STR18##and its salts,wherein X is --O--, --S--, --NH-- or --CH.sub.2 -- andwherein R is selected from the group consisting of: ##STR19##wherein K is --CH.sub.3, --CF.sub.3, --CHF.sub.2, or --CH.sub.2 F; with the proviso that when R is ##STR20##and K is --CH.sub.3, X is not --O--; andQ is --L.sup.1 --Z, where L.sup.1 is a linker containing at least one carbon atom;wherein Z is selected from the group consisting of the moieties--NH.sub.2,--COOH,--SH, ##STR21##--NH--C(.dbd.O)--L.sup.2 --M, ##STR22##a moiety which reacts with a protein to form a covalent bond, or any combination or repetition of said moieties;where L.sup.2 is a linker containing at least one carbon atom; where M is halide or maleimide; andwherein J is --O--, --S--, --NH-- or --CH.sub.2 --.