Patent ID: 9187517
Filing Date: 2015-11-17
Classification: A61K,A61P,C07H,C07K,C12N

Abstract:
1. A cartilage complex in a damaged cartilage tissue, wherein said complex comprises a compound having the formula: B-(J) n -(Z) q , or (Z) q -(J) n -B and a plurality of chondrocytes, wherein the compound is bound to at least one chondrocyte in the damaged cartilage tissue, and wherein: B is insulin-like growth factor-1 (IGF-1); J is a proteinogenic amino acid or a linker; Z is a peptide comprising the amino acid sequence of SEQ ID NO:3 or consisting of the amino acid sequence of amino acids 1-21 of SEQ ID NO:3; n is an integer from 0-10; and q is an integer from 1-5.