Patent ID: 6653501
Filing Date: 2003-11-25
Classification: C07B,C07C,Y02P

Abstract:
A method of processing a solution having a plurality of optical isomers, thereby to obtain a (2R,3S) target isomer having a formula: wherein P1 is selected from H and a hydroxyl protecting group, R1 is selected from H, an alkyl group, an olefinic group and an aromatic group, and R2 is selected from H and R3CO, where R3 is selected from an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group and an O-aromatic group, provided that R1 is not H when R3 is Ph and P1 is H, comprising the steps of: (a) passing the solution through a chromatographic stationary phase that has a greater affinity for one of the target isomer and an optical isomer thereof, such that the target isomer passes through said stationary phase at a different rate than does said optical isomer thereof, said stationary phase having a formula â€ƒ;and (b) collecting a portion of the solution containing the target isomer.