Patent ID: 6040431
Filing Date: 2000-03-21
Classification: A61P,C07K

Abstract:
A biosynthetic single-chain protein comprising:a single polypeptide chain defined by a formula selected from the group consisting of:(a) F1-L-F2-L-H;(b) F1-L-H-L-F2;(c) F2-L-F1-L-H;(d) F2-L-H-L-F1;(e) H-L-F1-L-F2; and(f) H-L-F2-L-F1;wherein F1 comprises an amino acid sequence comprising amino acid residues 7-26 of SEQ ID NO: 16, H comprises an amino acid sequence comprising amino acid residues 56-62 of SEQ ID NO: 16, F2 comprises an amino acid sequence comprising amino acid residues 79-87 of SEQ ID NO:16, and L comprises a polypeptide linker, andwherein the single-chain protein is capable of inducing endochondral bone formation in a mammal.