Patent ID: 7001900
Filing Date: 2006-02-21
Classification: A61P,C07D

Abstract:
1. A compound of the Formula I: wherein Azabicyclo is X is O or S; R R k is 1 or 2; W is any positional isomer of pyridinyl, pyrimidinyl, naphthyl, quinolinyl, or isoquinolinyl, any of which is optionally substituted with 1–2 substituents independently selected from F, Cl, lower alkyl, lower halogenated alkyl, lower substituted alkyl, lower alkynyl, ——CN, ——NO wherein substituted alkyl is an alkyl moiety from 1–6 carbon atoms having 0–3 substituents independently selected from F, Cl, Br, or I and further having 1 substituent selected from R wherein lower substituted alkyl is lower alkyl having 0–3 substituents independently selected from F, Cl, Br, or I, and further having 1 substituent selected from ——OR wherein each R wherein any lower alkyl, cycloalkyl, heterocycloalkyl, or phenyl is optionally substituted with up to two halogens independently selected from F or Cl, and is further optionally substituted with one other substituent independently selected from ——OR wherein each R wherein substituted alkenyl is an unsaturated alkenyl moiety having from 2–6 carbon atoms and having 0–3 substituents independently selected from F, or Cl, and further having 1 substituent selected from R wherein substituted alkynyl is an unsaturated alkynyl moiety having from 3–6 carbon atoms and having 0–3 substituents independently selected from F, or Cl, and further having 1 substituent selected from R wherein substituted cycloalkyl is a cyclic moiety having from 3–6 carbon atoms and having 0–3 substituents independently selected from F, or Cl, and further having 1 substituent selected from ——OR wherein substituted heterocycloalkyl is a cyclic moiety having from 4–7 atoms with 1–2 atoms within the ring being ——S——, ——N(R R or R wherein each A is independently CR 18 or N, provided that only up to one A is N, E 1 and E 2 are independently selected from CR 18 , O, S, or NR 14 , and G is CR 18 , provided that R 18 or R 14 of E 1 , E 2 , and G can be a bond when ———forms a double bond and further provided that only one R 18 or R 14 can be a bond for bonding R 7 to a moiety to which it is attached; Each R R R Each R Each R R R Each R R Each R