Patent ID: 6403577
Filing Date: 2002-06-11
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula wherein:R1 is hexamethyleneiminyl; which may be substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, amino, C1-C4 alkylamino, di(C1-C4 alkyl)amino, phenyl, piperazinyl, C3-C8 cycloalkyl, benzyl, piperidinyl, pyrimidinyl, C2-C6 alkanoylamino, pyrrolidinyl, C2-C6 alkanoyl, or C1-C4 alkoxycarbonyl; any one of which phenyl, piperazinyl, C3-C8 cycloalkyl, benzyl, C1-C4 alkyl, piperidinyl, pyrrolidinyl, C2-C6 alkanoyl, or C1-C4 alkoxycarbonyl groups may be substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, amino, C1-C4 alkylamino, di(C1-C4 alkyl)amino, or C2-C4 alkanoylamino; R2 is â€”COâ€”R6; R6 is hydrogen, C1-C4 alkyl, C1-C3 haloalkyl, phenyl, C1-C3 alkoxy, C1-C3 hydroxyalkyl, amino, C1-C4 alkylamino, or di(C1-C4 alkyl)amino Ra is halo, C1-C3 alkoxy, C1-C3 alkylthio, nitro, trifluoromethyl, or C1-C3 alkyl; and Rb is hydrogen, halo, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, amino, C1-C4 alkylamino, or di(C1-C4 alkyl)amino; or pharmaceutically acceptable salt or solvate thereof.