Patent ID: 6677367
Filing Date: 2004-01-13
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound selected from the group consisting of a compound of formula Iband when the compound of formula Ib comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein Cx is selected from the group consisting of â€”COOM, and 13 CH2OH, M being an alkali metal or alkaline earth metal, wherein R1A is selected from the group consisting of a straight or branched alkyl group of 1 to 6 carbon atoms, a cycloalkylalkyl group having 3 to 6 carbon atoms in the cycloalkyl part thereof and 1 to 3 carbon atoms in the alkyl part thereof, wherein R2A, R2Aâ€², R4B and R4Bâ€² are independently selected from the group consisting of H, a straight or branched alkyl group of 1 to 4 carbon atoms, F, Cl, Br, I, â€”CF3, â€”NO2, â€”NR10R11, â€”NHCOR10, â€”OR10, â€”OCH2C6H5, â€”SR10, â€”COOR10, â€”COR10 and â€”CH2OH, wherein R5A is selected from the group consisting of H, a straight or branched alkyl group of 1 to 8 carbon atoms, HOCH2â€”, C6H5CH2OCH2â€”, benzyl-OCH(CH3), HO2CCH2â€”, HO2CCH2CH2â€”, NCâ€”CH2â€”, H2NC(O)CH2â€”, H2NC(O)CH2CH2â€”, 4-CH3C6H4CH2SCH2â€”, CH3SCH2CH2â€”, H2NCH2CH2CH2CH2â€”, C6H5â€”, C6H5CH2â€”, C6H5CH(OH)â€”, C6H5CH(CN)â€”, C6F5CH2â€”, 4-(9-fluorenylmethoxycarbonyl)-NHCH2 â€”C6H4CH2â€” and benzyl substituted by a group selected from the group consisting of H, a straight or branched alkyl group of 1 to 4 carbon atoms, F, Cl, Br, I, â€”CF3, â€”NO2, â€”NR10R11, â€”NHCOR10, â€”OR10, â€”OCH2C6H5, â€”SR10, â€”COOR10, â€”COR10 and â€”CH2OH, wherein each m is independently 0 or 1, wherein n is 3 or 4, wherein each o is independently 0 or 1, and wherein R10 and R11 are independently selected from the group consisting of H, a straight or branched alkyl group of 1 to 4 carbon atoms.