Patent ID: 8664470
Filing Date: 2014-03-04
Classification: A01K,A61K,A61P

Abstract:
1. A method of producing a mouse having one or more pathological characteristics of retinal degeneration comprising: a) subcutaneously administering to a mouse a composition comprising an adjuvant and a carboxyethylpyrrole (CEP) adducted mouse serum albumin to produce antibodies against CEP; and b) maintaining the mouse of step (a) under conditions in which one or more pathological characteristics of retinal degeneration develops in said mouse, wherein one or more pathological characteristics of retinal degeneration is selected from the group consisting of lysis of retinal pigmented epithelium (RPE) cells, the presence of invading inflammatory cell in the interphotoreceptor matrix (IPM), and focal loss of RPE, thereby producing mouse having one or more pathological characteristics of retinal degeneration.