Patent ID: 6509034
Filing Date: 2003-01-21
Classification: A61K

Abstract:
A process to prepare a wettable microcapsule comprising a drug encapsulated by ethylcellulose, said ethylcellulose having deposited thereon one or more surfactants and optionally a binder, wherein the quantity of dry surfactant expressed as % w/w over the hydrophobic cores ranges from 0.010% and 2.000%, said process comprising the steps of:applying ethylcellulose onto said drug by phase separation, thereby obtaining drug particles encapsulated in ethylcellulose spray coating, in a fluidized bed, the encapsulated drug particle with a solution having a concentration of surfactant+optional binder comprised between 0.1% and 10.0% by weight in a solvent in which said ethylcellulose forming the outer membrane of the microcapsule is insoluble, and drying to form an outer layer of surfactant.