Patent ID: 6020336
Filing Date: 2000-02-01
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR16## wherein: n is 0 or 1,A represents a .sigma. bond or linear or branched (C.sub.1 -C.sub.8)alkylene, or linear or branched (C.sub.1 -C.sub.8)alkenylene,X represents nitrogen or C--R.sub.2 wherein R.sub.2 represents hydrogen, or linear or branched (C.sub.1 -C.sub.6)alkyl,R.sub.1 represents hydrogen, or linear or branched (C.sub.1 -C.sub.6)alkyl,G.sub.1 represents ##STR17## wherein: R.sub.3 and R.sub.4 each independently of the other represent hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl-(C.sub.1 -C.sub.6)-alkyl in which the alkyl is linear or branched, optionally substituted aryl-(C.sub.1 -C.sub.6)alkyl in which the alkyl is linear or branched, or optionally substituted aryl, or together with the nitrogen atom that carries them, R.sub.3 and R.sub.4 form a group: ##STR18## wherein B represents a .sigma. bond or linear or branched (C.sub.1 -C.sub.6)alkylene, and R.sub.5 represents hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)-cycloalkyl, optionally substituted aryl, optionally substituted aryl-(C.sub.1 -C.sub.6)alkyl in which the alkyl is linear or branched, optionally substituted heteroaryl, or optionally substituted heteroaryl-(C.sub.1 -C.sub.6)alkyl in which the alkyl is linear or branched, their enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, it being understood that:""aryl"" is understood to mean a group selected from phenyl and naphthyl,""heteroaryl"" is understood to mean a group selected from furyl, thienyl, pyridyl, pyrrolyl, imidazolyl, tetrazolyl, pyrazinyl and pyrimidinyl,and the term optionally substituted applied to the terms ""phenyl"", ""benzyl"", ""aryl"", ""arylalkyl"", ""heteroaryl"" and ""heteroarylalkyl"" means that the groups in question may be substituted by one or more halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxy, and/or linear or branched (C.sub.1 -C.sub.6)trihaloalkyl.