Patent ID: 6294566
Filing Date: 2001-09-25
Classification: A61P,C07D

Abstract:
A compound having the structure: ##STR24##wherein X is CR.sub.7 ;wherein Y is CO or CR.sub.3 R.sub.5 ;wherein each R.sub.2 is independently H; F; Cl; Br; I; --NO.sub.2 ; --CN; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, or C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --OH; --(CH.sub.2).sub.q OH; --COR.sub.4 ; CO.sub.2 R.sub.4 ; CONHR.sub.4 ; phenyl; or benzyl;wherein each R.sub.3 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --(CH.sub.2).sub.q OH; --OH; .dbd.N--OR.sub.4 ; --COR.sub.4 ; --CO.sub.2 R.sub.4 ; --CONHR.sub.4 ; phenyl; or benzyl;wherein each R.sub.4 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, or C.sub.1 -C.sub.4 polyfluoroalkyl; or phenyl;wherein each R.sub.5 is independently H; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, or C.sub.1 -C.sub.4 polyfluoroalkyl;wherein each R.sub.7 is independently H; --CN; straight chained or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 monofluoroalkyl, or C.sub.1 -C.sub.4 polyfluoroalkyl; straight chained or branched C.sub.1 -C.sub.4 alkoxy; --OH; --(CH.sub.2).sub.q OH; --COR.sub.4 ; --CO.sub.2 R.sub.4 ; --CONHR.sub.4 ; phenyl; or benzyl;wherein m and n are each independently 0, 1, 2 or 3, provided that m+n is 2 or 3;wherein each p is independently 0, 1 or 2;wherein each q is independently 0, 1, 2 or 3; andwherein the compound is the (+) enantiomer;or a pharmaceutically acceptable salt thereof.