Patent ID: 8859267
Filing Date: 2014-10-14
Classification: B01L,G01N

Abstract:
1. A chip for optical analysis comprising: a substrate that is transparent to a measurement light; a chip main body joined to a surface of the substrate; an introduction port formed on the chip main body for introducing a liquid sample that contains a predetermined component to be measured; an observation section arranged between the substrate and the chip main body and configured to be irradiated with the measurement light; a first passage extending between the introduction port and the observation section; a metal thin film layer positioned on a wall surface of the first passage at the observation section; a second passage that branches from the first passage at a first position of the first passage such that at the first position, a first portion of the liquid sample introduced at the introduction port flows through the first passage and a second portion of the liquid sample flows into the second passage, the second passage merging back into the first passage at a second position of the first passage, the first and second positions of the first passage being on the upstream side of the observation section such that the second portion of the liquid sample flows back into the first passage and then into the observation section; an adsorption region for adsorbing the predetermined component to be measured from the first portion of the liquid sample to form a reference sample devoid of the predetermined component to be measured, the adsorption region being positioned in the first passage between the first and second positions so that the second position is between the adsorption region and the observation section, and the adsorption region comprising at least one adsorbent selected from: a dextran gel using protein A as a modifier, an organic membrane-coated silica, and an organic membrane-coated alumina; and means for generating a difference in time to reach the observation section so that the reference sample of the first portion arrives at the observation section through the first passage earlier than the second portion of the liquid sample that passes through the second passage so that optical measurements related to the reference sample can be obtained at the observation section to provide a baseline before the liquid sample arrives at the observation section.