Patent ID: 7714135
Filing Date: 2010-05-11
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein Ra is —C(O)OR1, R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, T is 1-6C-alkylene or 3-7C-cycloalkylene, Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, each R2 may be the same or different and is independently selected from the group consisting of: each R3, R4, R5 and R6 may be the same or different and is each independently selected from the group consisting of: each R7 may be the same or different and is independently selected from the group consisting of: each R8 and R9 may be the same or different and is each independently selected from the group consisting of: each R10 may be the same or different and is independently selected from the group consisting of: each y is 1, 2,3 or 4, each Rba, Rbb, and Rbc may be the same or different and is each independently selected from the group consisting of: each Har is the same or different and is independently a fully aromatic or partially aromatic mono- or fused bicyclic ring or ring system, which contains at least one heteroatom in the ring or ring system, made up of a first constituent being a 5- or 6-membered monocyclic unsaturated, aromatic heteroaryl ring A, and, optionally, fused to said first constituent, a second constituent being a benzene ring, a 5-6C-cycloalkane ring, an additional heteroaryl ring A or a heterocyclic ring B, wherein said Har is attached via a substitutable ring carbon or ring nitrogen atom of Har, each Het is the same or different and is independently a fully saturated or partially unsaturated mono- or fused bicyclic ring or ring system made up of a first constituent being a 3- to 7-membered monocyclic fully saturated or partially unsaturated, non-aromatic heterocyclic ring B, and, optionally, fused to said first constituent, a second constituent being a benzene ring, a 3-7C-cycloalkane ring, or an additional heterocyclic ring B, wherein said Het is attached via a substitutable ring carbon or ring nitrogen atom; under the first proviso, that those compounds, in which T is methylene substituted by 1-5C-alkyl, are disclaimed, and under the second proviso, that 3-cyano-2-(3-phenyl-propanyolamino)-4,7-dihydro-6H-thieno[2,3-c]pyridine-6-carboxylic acid ethyl ester is also disclaimed; or a salt thereof.