Patent ID: 6156756
Filing Date: 2000-12-05
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR11## wherein: R.sup.1 is a C.sub.1-6 alkyl, C.sub.3-8 -cycloalkyl or a phenyl group, each group being optionally substituted by one or more substituents selected from halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11 or C.sub.1-6 alkyl (itself optionally substituted by one or more halogen atoms);R.sup.2 is C.sub.1-8 alkyl optionally substituted by one or more substituents selected from halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11, C.sub.3-8 -cycloalkyl, aryl (optionally substituted by one or more alkyl groups and/or halogen atoms), or C.sub.1-6 -alkyl; or R.sup.2 is a C.sub.3-8 -cycloalkyl group optionally substituted by one or more substituents selected from halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11, C.sub.1-6 -alkyl or phenyl (the latter two being optionally substituted by one or more substituents selected from halogen, NO.sub.2, C(O)R.sup.8, OR.sup.8, SR.sup.11, NR.sup.12 R.sup.13, phenyl and C.sub.1-6 -alkyl which is optionally substituted by one or more halogen atoms);one of R.sup.3 or R.sup.4 is hydroxy and the other is hydrogen, hydroxy or NR.sup.9 R.sup.10 ;R.sup.5 is (CH.sub.2).sub.n NR.sup.14 R.sup.15 where n is 0 to 6 and R.sup.14 and R.sup.15 are independently hydrogen, C.sub.1-6 -alkyl or phenyl; or R.sup.5 is CONR.sup.16 R.sup.17 where R.sup.16 is hydrogen or C.sub.1-6 -alkyl, and R.sup.17 is C.sub.1-6 -alkyl or C.sub.3-6 -cycloalkyl each of which is substituted by NR.sup.18 R.sup.19 and optionally substituted by phenyl, or R.sup.17 is C.sub.1-6 -alkyl or C.sub.3-6 -cycloalkyl substituted by phenyl which is substituted by NR.sup.18 R.sup.19 where R.sup.18 and R.sup.19 are independently hydrogen, C.sub.1-6 -alkyl or phenyl; or R.sup.17 is a 5- to 8-membered saturated heterocycle containing one or more nitrogen atoms and optionally substituted on nitrogen by hydrogen, C.sub.1-6 -alkyl or phenyl; or R.sup.16 and R.sup.17 together with the nitrogen atom to which they are attached form a 5- to 8-membered ring which is substituted by NR.sup.18 R.sup.19 as defined above; or R.sup.16 together with R.sup.19 forms a 6- to 8-membered ring containing the two nitrogen atoms in which R.sup.17 and R.sup.18 are as defined above; or R.sup.5 is (CH.sub.2).sub.p NR.sup.20 CO(CH.sub.2).sub.q OR.sup.21 or (CH.sub.2).sub.p NR (CH.sub.2).sub.q NR.sup.23 COR.sup.24 where p and q are independently 1 to 4 and R.sup.20, R.sup.21, R.sup.22, R.sup.23 and R.sup.24 are independently C.sub.1-4 -alkyl or phenyl; or R.sup.5 is CH.dbd.CHCH.sub.2 NR.sup.25 R.sup.26 where R.sup.25 is hydrogen, C.sub.1-6 alkyl or phenyl and R.sup.26 is hydrogen or (CH.sub.2).sub.y NR.sup.27 R.sup.28 where y is 2-4 and R.sup.27 and R.sup.28 are independently hydrogen, C.sub.1-6 alkyl or phenyl;R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 -alkyl; andR.sup.12 and R.sup.13 are independently hydrogen, C.sub.1-6 -alkyl or acyl groups;or a pharmaceutically acceptable salt or solvate thereof.