Patent ID: 7468184
Filing Date: 2008-12-23
Classification: A61K,A61P,C07K

Abstract:
1. A method for preventing or treating at least one symptom of cachexia, comprising administering to a patient suffering from cachexia at least one humanized anti-PTHrP antibody or binding fragment thereof, wherein said humanized anti-PTHrP antibody or binding fragment thereof: a) is humanized FERM BP-5631; b) comprises a heavy chain variable region comprising amino acids 31-35, 50-66, and 99-107 of SEQ ID NO:46 and a light chain variable region comprising amino acids 23-34, 50-60, and 93-105 of SEQ ID NO:45; or c) comprises a deletion, replacement, addition, or insertion of from 1-5 amino acid residues of humanized FERM BP-5631; and wherein said humanized anti-PTHrP antibody or binding fragment thereof binds PTHrP.