Patent ID: 6140354
Filing Date: 2000-10-31
Classification: A61P,C07C,C07D

Abstract:
A compound of formula 1 ##STR160## wherein R.sub.1 is independently selected from the group consisting of hydrogen; hydroxy; halo; C.sub.1-8 alkoxy; substituted C.sub.1-8 alkoxy wherein the substituent is halo; trifluoroalkyl; C.sub.1-8 alkylthio and substituted C.sub.1-8 alkylthio wherein the substituent is selected from halo, trifluoroalkyl and C.sub.1-8 alkoxy; C.sub.3-6 cycloalkyl; C.sub.3-8 cycloalkoxy; nitro; amino; C.sub.1-6 alkylamino; C.sub.1-8 dialkylamino; C.sub.4-8 cycloalkylamino; cyano; carboxy; C.sub.1-5 alkoxycarbonyl; C.sub.1-5 alkylcarbonyloxy; formyl; carbamoyl; phenyl; substituted phenyl wherein the substitutent is selected from halo, hydroxyl, nitro, amino and cyano;n is 0-2B.sub.2 is selected from the group consisting of hydrogen; C.sub.1-5 alkyl; substituted C.sub.1-5 alkyl wherein the substituent is halogen;Y is methylenem 0-3R.sub.2 is selected from the group consisting of hydrogen; hydroxy; C.sub.1-6 -alkyl; C.sub.1-6 alkenyl; C.sub.3-7 cycloalkyl; halo; phenyl; substituted phenyl wherein the substituent is selected from halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trifluoroC.sub.1-6 alkyl, cyano, nitro, amino, C.sub.1-6 alkylamino, and C.sub.1-6 dialkylamino; naphthyl; phenoxy; substituted phenoxy wherein the substituent is selected from halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trifluoroC.sub.1-6 alkyl, cyano and nitro; phenylthio and substituted phenylthio wherein the substituent is selected from halo, C.sub.1-6 alkyl, nitro and amino; a heteroaryl group such as pyridyl, pyrimidyl, furyl, thienyl, and imidazolyl; substituted heteroaryl wherein the substitutent is selected from C.sub.1-6 alkyl and halo; and heterocycloalkyl;B.sub.1 is selected from the group consisting of hydrogen; C.sub.1-5 alkyl; substituted C.sub.1-5 alkyl wherein the substituent is halo;L is selected from the group consisting of C.sub.1-8 alkylene; C.sub.2-10 alkenylene; C.sub.2-10 alkynylene;C.sub.1-4 alkylenecycloalkylC.sub.1-4 alkylene; C.sub.2-4 alkenylenecycloalkylC.sub.2-4 alkenylene;C.sub.2-4 alkynylenecycloalkylC.sub.2-4 alkynylene; C.sub.1-4 alkylenearylC.sub.1-6 alkylene; andC.sub.2-4 alkenylenearylC.sub.2-4 alkenylene;R.sub.3 is selected from C.sub.1-8 alkyl; substituted C.sub.1-8 alkyl wherein the substituent is selected from alkoxy and halo; cycloalkyl; substituted cycloalkyl wherein the substituent is selected from alkoxy and halo; phenyl; substituted phenyl wherein the substituent is selected from C.sub.1-8 alkyl, halo, nitro, amino, alkylamino, alkylsulfonyl, alkoxy and cyano; naphthyl; substituted naphthyl wherein the substituent is selected from halo, nitro, amino and cyano; heteroaryl wherein the heteroaryl group is selected from pyridyl, pyrimidyl, furyl, thienyl and imidazolyl; and substituted heteroaryl wherein the substituent is selected from halo, nitro, amino and cyano;and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof with the proviso that when m is 0, R2 cannot be hydrogen or alkyl.