Patent ID: 7314868
Filing Date: 2008-01-01
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A method of fusing unwanted tumor cells in a human patient, comprising administering to said patient a composition in an amount sufficient to cause fusion of said unwanted tumor cells, wherein said composition comprises a nucleic acid vector and a diluent that does not include culture serum, wherein said nucleic acid vector comprises a nucleotide sequence encoding a measles virus F glycoprotein and a nucleotide sequence encoding a chimeric measles virus H glycoprotein, wherein said measles virus F glycoprotein is expressible on a eukaryotic cell surface, wherein said chimeric measles virus H glycoprotein is expressible on a eukaryotic cell surface, wherein said chimeric measles virus H glycoprotein comprises a measles virus H glycoprotein and a receptor binding component of a ligand, and wherein said composition is directly delivered to said unwanted tumor cells.