Patent ID: 6403596
Filing Date: 2002-06-11
Classification: A61P,C07D

Abstract:
A compound of the formula wherein:A is CN, COOH, NO2, COO(C1-C6 alkyl), (C1-C6 alkyl)-NH2 or CONR6R7; Q is N; R1 is hydrogen, NHCH(CH3)phenyl or NH(CH2)3â€”Oâ€”CH2CH3; R2, R3 and R4 are independently hydrogen or CF3; and R6 and R7 are independently hydrogen, C1-C6 alkyl or a saturated 5 to 7 membered heterocyclic ring containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 S or O atom; or R6 and R7 are taken together with the nitrogen atom to form a saturated 6 membered heterocyclic ring containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 S or O atom, said ring optionally substituted by 1-3 groups selected from C1-C6 alkyl, halogen, hydroxy, CF3, NH2 and NO2; or a pharmaceutically acceptable addition salt and/or hydrate thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof.