Patent ID: 6565830
Filing Date: 2003-05-20
Classification: A61K,C07C,C07F,Y10S

Abstract:
In a method of susceptibility imaging comprising imaging a patient to whom a susceptibility reagent has been administered, the improvement wherein said susceptibility reagent is a physiologically acceptable chelate compound of formula I whereinZ1 and Z2 are each independently H or â€”(CH2)mâ€”(C6H4)qâ€”(O)kâ€”(CH2)nâ€”(C6H4)lâ€”(O)râ€”R, m and n are each independently 0-20, k, l, q and r are each independently 0 or 1, and R is H, C1-C6-alkyl, C1-C6-alkyl substituted by OR1, or CH2COOR1, R1 is H, C1-C6-alkyl, or benzyl, R2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-6-alkyl or benzyl, or a sulfone group esterified with C1-6-alkyl or benzyl, an aryl group of up to 10 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-C6-alkyl or benzyl or a sulfone group esterified with C1-C6-alkyl or benzyl, or an aralkyl group of up to 16 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-C6-alkyl or benzyl, or a sulfone group esterified with C1-C6-alkyl or benzyl, R3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms, which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-C6-alkyl or benzyl, or a sulfone group esterified with C1-C6-alkyl or benzyl, an aryl group of up to 10 C-atoms which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-6-alkyl or benzyl, or a sulfone group esterified with C1-C6-alkyl or benzyl, or an aralkyl group of up to 16 C-atoms optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C1-C6-alkyl or benzyl, or a sulfone group esterified with C1-C6-alkyl or benzyl, X is, in each case independently, H or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, wherein acid groups are, in each case, optionally present as an ester with C1-C6-alkyl, benzyl or 4-methoxybenzyl, or as an amide wherein the nitrogen atom of said amide is substituted by at least one saturated or unsaturated straight-chain, branched-chain or cyclic hydrocarbon radical with up to 5 C atoms, wherein said at least one hydrocarbon radical is optionally substituted by 1-3 hydroxy groups and/or 1-3 C1-C4-hydroxy groups, or said amide is in the form of a 5- or 6-membered heterocyclic ring with inclusion of the amide nitrogen atom; or a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,wherein at least two of substituents X are metal ion equivalents of at least one element of atomic numbers 21-29, 42, 44 or 58-70, at least one of substituents Z1 and Z2 is H, and, if n and l are each 0, then k and r are not both 1.