Patent ID: 8354378
Filing Date: 2013-01-15
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating a cardiovascular disorder in a mammal, comprising administering to a mammal in need thereof in an amount sufficient to reduce the severity of the disorder a polypeptide comprising: a) a first domain comprising a third intracellular loop, or a fragment thereof of a Protease-Activated Receptor (PAR); and b) a second domain, attached to the first domain, wherein the second domain comprises a cell-penetrating, membrane-tethering moiety comprising: a lipid, a cholesterol, a phospholipid, a steroid, a sphingosine, a ceramide, an octyl-glycine, a 2-cyclohexylalanine, or a benzolylphenylalanine; wherein the polypeptide is a PAR antagonist, wherein the first domain does not comprise an extracellular portion of the PAR, and wherein the first domain comprises at least 3 contiguous amino acid residues of the third intracellular loop.