Patent ID: 6995260
Filing Date: 2006-02-07
Classification: A61K,C07D

Abstract:
1. A compound of the formula wherein: Y provided that at least four of (Y 1 ) a , (Y 2 ) b , (Y 3 ) c , and (Y 4 ) d are represented by formula (2); X is oxygen or sulfur; R Z is a carborane cluster comprising at least two carbon atoms and at least three boron atoms, or at least one carbon atom and at least five boron atoms, within a cage structure; r is 0 or an integer from 1 to 20; W a, b, c, and d independently represent an integer from 1 to 4; m, n, p, and q are independently 0 or an integer from 1 to 4; provided that at least one of m, n, p, and q is not zero, and each of the sums a+m, b+n, c+p, and d+q, independently represents an integer from 1 to 5; and M is either two hydrogen ions; a single monovalent metal ion; two monovalent metal ions; a divalent metal ion; a trivalent metal ion; a tetravalent metal ion; a pentavalent metal ion; a hexavalent metal ion; a radioactive metal ion useful in radioisotope-mediated radiation therapy or imageable by single photon emission computed tomography (SPECT) or positron emission tomography (PET); a paramagnetic metal ion detectable by magnetic resonance imaging (MRI); a metal ion suitable for boron neutron capture therapy (BNCT) or photodynamic therapy (PDT); or a combination thereof; wherein when M is a single monovalent metal ion, the compound is charge-balanced by a counter cation; and when M is a trivalent, tetravalent, pentavalent, or hexavalent metal ion, the compound is charge-balanced by an appropriate number of counter anions, dianions, or trianions.