Patent ID: 7803555
Filing Date: 2010-09-28
Classification: A61K,C07K,G01N

Abstract:
1. A method for identifying a candidate agent for reducing the incidence of binding of filovirus to a folate receptor, or reducing the incidence of internalization of filovirus into a permissive cell the treatment of a filovirus associated disease condition, said method comprising: a) contacting a folate receptor with a filovirus or a folate receptor-binding fragment of a filovirus envelope glycoprotein and a test compound; and b) determining the effect of said test compound on the binding interaction between said folate receptor and said folate receptor-binding fragment of a filovirus envelope glycoprotein or said filovirus; wherein a test compound that reduces the binding interaction between said folate receptor and said folate receptor-binding fragment of a filovirus envelope glycoprotein or said filovirus, compared to the binding interaction in the absence of the test compound, is a candidate agent for reducing the incidence of binding of filovirus to a folate receptor, or reducing the incidence of internalization of filovirus into a permissive cell.