Patent ID: 6667320
Filing Date: 2003-12-23
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound of the formulaVâ€”CR2â€”Ar1â€”CR2NRâ€”(CR2)xâ€”Ar2 wherein V is a heterocycle of 9-24 members containing 2-4 optionally substituted amine nitrogen atoms spaced from each other by 2 or more optionally substituted carbon atoms, and which heterocycle may optionally comprise a fused aromatic or heteroaromatic ring, and wherein (a) said heterocycle contains at least one O or S, said O or S spaced from any adjacent heteroatom by at least 2 carbon atoms, and wherein said S is optionally oxidized, or (b) the heterocycle contains 3 N and at least one carbon atom in said heterocycle is substituted by at least one fluoro substituent, or (c) both (a) and (b); and wherein each R is independently H or a straight chain, branched or cyclic alkyl containing 1-6C; x is 0-4; Ar1 is an unsubstituted or substituted aromatic or heteroaromatic moiety; and Ar2 is an unsubstituted or substituted aromatic or heterocyclic group; and the pharmaceutically acceptable salts and protected forms thereof.