Patent ID: 9150542
Filing Date: 2015-10-06
Classification: C07D

Abstract:
1. A process for the preparation of crystalline Form I of a methanesulfonate salt of dabigatran etexilate, wherein the process comprises a) contacting ethyl N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-3a,7a-dihydro-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-β-alaninate of Formula IV  or salts thereof with n-hexyl chloroformate; b) treating the reaction mixture obtained in step a) with methane sulfonic acid; and c) isolating the crystalline Form I of the methanesulfonate salt of dabigatran etexilate from the mixture thereof.