Patent ID: 6582728
Filing Date: 2003-06-24
Classification: A61K,A61M,A61P,B82Y,C12N,Y10S

Abstract:
A method for preparing a dry powder composition for pulmonary administration, said method comprising the following steps performed sequentially:(a) providing an aqueous solution comprising a pharmaceutically active macromolecule and a pharmaceutically acceptable carrier selected from the group consisting of human serum albumin, carbohydrates, amino acids, polypeptides, buffers, and salts; and (b) spray drying said aqueous solution from step (a) at a temperature in the range from 50Â° C. to 200Â° C. to produce a non-liposomal dry powder composition suitable for pulmonary administration comprising a therapeutically effective amount of said pharmaceutically active macromolecule and said pharmaceutically acceptable carrier and having a moisture content below 10% by weight, wherein said pharmaceutically active macromolecule retains its activity upon spray drying.