Patent ID: 8545842
Filing Date: 2013-10-01
Classification: A61K,A61P,C07K

Abstract:
1. An isolated monoclonal antibody, wherein said antibody is selected from the group consisting of: a) an antibody comprising a heavy chain sequence comprising SEQ ID NO:427 and a light chain sequence comprising amino acids 21-234 of SEQ ID NO:429; b) an antibody or fragment thereof comprising a light chain variable region sequence comprising SEQ ID NO:40 and a heavy chain variable region sequence comprising SEQ ID NO:14; and c) an antibody or fragment thereof comprising a heavy chain CDR1 comprising SEQ ID NO:146, a heavy chain CDR2 comprising SEQ ID NO:147, a heavy chain CDR3 comprising SEQ ID NO:148, a light chain CDR1 comprising SEQ ID NO:224, a light chain CDR2 comprising SEQ ID NO:225, and a light chain CDR3 comprising SEQ ID NO:226, wherein said antibody, or fragment thereof, specifically binds human IL-17 receptor A of SEQ ID NO:431, and wherein said antibody is recombinantly-produced from a Chinese Hamster Ovary (CHO) cell.