Patent ID: 6642255
Filing Date: 2003-11-04
Classification: A61P,C07D

Abstract:
A compound of formula I: or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein;A is CONHOH, ring B is a 5 membered heterocyclic ring consisting of: 4 carbon atoms, 0-1 carbonyl groups 0-2 double bonds, and 1 heteroatom selected from Nâ€”, and NR2, provided that Nâ€”R2 forms other than an Nâ€”O, Nâ€”N, or Nâ€”S bond; Z is phenyl substituted with 0-5 Rb; Ua is O, NRa1, or C(O); Xa is methylene; Ya is absent or is selected from O, NRa1, S(O)p, and C(O); Za is quinoline substituted with 0-5 Rc; R1a is selected from H, C1-4 alkyl, phenyl, benzyl, CH2OR3, and CH2NRaRa1; R1b is selected from H, C1-4 alkyl, phenyl, benzyl, CH2OR3, and CH2NRaRa1; R2 is selected from Q, C1-10 alkylene-Q substituted with 0-3 Rb1, C2-10 alkenylene-Q substituted with 0-3 Rb1, C2-10 alkynylene-Q substituted with 0-3 Rb1, (CRaRa1)r1O(CRaRa1)r-Q,(CRaRa1)r1NRa(CRaRa1)r-Q, (CRaRa1)r1C(O)(CRaRa1)r-Q,(CRaRa1)r1C(O)O(CRaRa1)r-Q, (CRaRa1)r1OC(O)(CRaRa1)r-Q,(CRaRa1)r1C(O)NRaRa1, (CRaRa1)r1C(O)NRa(CRaRa1)r-Q,(CRaRa1)r1NRaC(O)(CRaRa1)r-Q, (CRaRa1)r1OC(O)O(CRaRa1)r-Q,(CRaRa1)r1OC(O)NRa(CRaRa1)r-Q, (CRaRa1)r1NRaC(O)O(CRaRa1)r-Q,(CRaRa1)r1NRaC(O)NRa(CRaRa1)r1-Q, (CRaRa1)r1S(O)p(CRaRa1)r-Q,(CRaRa1)r1SO2NRa(CRaRa1)r-Q, (CRaRa1)r1NRaSO2(CRaRa1)r-Q, and (CRaRa1)r1NRaSO2NRa(CRaRa1)r-Q; R2a is H, R2b is H; Q is selected from H, a C3-13 carbocycle substituted with 0-5 Rd and a 5-14 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and substituted with 0-5 Rd; R3, at each occurrence, is selected from Q1, C1-6 alkylene-Q1, C2-6 alkenylene-Q1, C2-6 alkynylene-Q1, (CRaRa1)r1O(CH2)r-Q1, (CRaRa1)r1NRa(CRaRa1)r-Q1, (CRaRa1)r1NRaC(O)(CRaRa1)r-Q1, (CRaRa1)r1C(O)NRa(CRaRa1)r-Q1, (CRaRa1)r1C(O)(CRaRa1)r-Q1,(CRaRa1)r1C(O)O(CRaRa1)r-Q1, (CRaRa12)r1S(O)p(CRaRa1)r-Q1 and (CRaRa1)r1SO2NRa(CRaRa1)r-Q1; alternatively, when two R3s are attached to the same carbon atom, they combine to form a 3-8 membered carbocyclic or heterocyclic ring consisting of: carbon atoms and 0-3 heteroatoms selected from the group consisting of N, O, and S(O)p, and substituted with 0-3 Rd; Q1 is selected from H, phenyl substituted with 0-3 Rd, naphthyl substituted with 0-3 Rd and a 5-10 membered heteroaryl consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and substituted with 0-3 Rd; Ra, at each occurrence, is independently selected from H, C1-4 alkyl, phenyl and benzyl; Ra1, at each occurrence, is independently selected from H and C1-4 alkyl; alternatively, Ra and Ra1 when attached to a nitrogen are taken together with the nitrogen to which they are attached to form a 5 or 6 membered ring comprising carbon atoms and from 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; Ra2, at each occurrence, is independently selected from C1-4 alkyl, phenyl and benzyl; Rb, at each occurrence, is independently selected from C1-6alkyl, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)O, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CF2CF3; Rb1, at each occurrence, is independently selected from ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, and NRaRa1; Rc, at each occurrence, is independently selected from C1-6 alkyl, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)O, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CF2CF3, C3-10 carbocycle and a 5-14 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; Rd, at each occurrence, is independently selected from C1-6 alkyl, ORa, Cl, F, Br, I, &boxH;O, â€”CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)O, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CF2CF3, C3-10 carbocycle and a 5-14 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; p, at each occurrence, is selected from 0, 1, and 2; p1 is 0, 1, or 2; r, at each occurrence, is selected from 0, 1, 2, 3, and 4; and, r1, at each occurrence, is selected from 0, 1, 2, 3, and 4.