Patent ID: 6048522
Filing Date: 2000-04-11
Classification: A61K,A61Q,C08F,Y10T

Abstract:
A controlled-release drug-delivery, emulsion composition suitable for topical application comprising: (a) the reaction product of the non-aqueous, heterogeneous polymerization of a reaction mixture comprising, by weight, about 5-70% of a vinyl monomer in about 30-95% of an oil as solvent, wherein the oil is selected from the group consisting of a silicone oil, a mineral oil or a water-insoluble organic ester and a free radical initiator, optionally in the presence of a crosslinking agent and/or an oil soluble surfactant, with agitation, under an inert gas, at about 40-150.degree. C. wherein the oil is present in an amount sufficient to keep the resultant vinyl polymer in a stirrable state until the end of the polymerization, (b) water to form an oil-in-water, a water-in-oil or a water-in-oil-in-water emulsion or gel, in a volume ratio of oil-in-water of 30:70 to 10:90, or water-in-oil of 90:10 to 30:70, (c) an added surfactant, if a suitable surfactant was not present during polymerization and (d) a pharmaceutical medicament.