Patent ID: 6162912
Filing Date: 2000-12-19
Classification: C07D

Abstract:
A process for the preparation of the compounds of formula (VII) starting from compound (I), through the monoalkylation reaction of the compound (I) with the alkylating agent (VI), to give the intermediate compound of formula (IX) and the subsequent hydrolysis of the compound (IX), to give the intermediate compound of formula (X), which is alkylated again with the alkylating agent (VI), to give the compounds of formula (VII), as represented in the following Scheme: ##STR59## in whichR is a hydrogen atom, a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl group, unsubstituted or substituted with 1 to 10 oxygen atoms, or a C.sub.1 -C.sub.20 alkyl group, optionally interrupted by a phenylene, phenyloxy or phenylenedioxy, in its turn substituted with a straight or branched C.sub.1 -C.sub.6 alkyl group, unsubstituted or substituted with 1 to 7 hydroxy groups or with 1 to 3 C.sub.1 -C.sub.7 groups;the aromatic group can be unsubstituted or substituted with alkoxy groups or halogens, carboxy, carbamoyl, alkoxycarbonyl, sulfamoyl, hydroxyalkyl, amino, acylamino, acyl, hydroxyacyl groups;X is a halogen or a sulfonic acid reactive residue;Y is a --OH or --OR, group, wherein R.sub.1 is a straight or branched C.sub.1 -C.sub.4 alkyl group; andwhen Y is the same as --OR.sub.1.