Patent ID: 8734775
Filing Date: 2014-05-27
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting endothelial cell motility, vessel formation and inducing vessel dissociation in a mammal diagnosed as having a chronic wound, comprising administering to the mammal an effective amount of a compound comprising a peptide that is at least 95% identical to the peptide of SEQ ID NO: 1; wherein said peptide binds with and activates chemokine receptor CXCR3 and wherein said activation of the chemokine receptor CXCR3 inhibits endothelial cell motility and vessel formation and induces vessel dissociation; and wherein the compound is applied to said chronic wound in the form of a topical formulation having said compound in a topical carrier; and wherein said topical formulation comprises two or more compounds that are ligands of chemokine receptor CXCR3.