Patent ID: 6635649
Filing Date: 2003-10-21
Classification: A61P,C07D

Abstract:
A compound having the following formula: whereinA is C(RaRb); Z is R3Oâ€”(Ar)â€”B, in which B is C(Rc); Ar is pyridyl linked to B at position 2; and R3 is H, alkyl substituted with aryl, or aryl; in which aryl is unsubstituted or substituted with one or more substitutents selected from the group consisting of halogen, hydroxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, cyano, nitro, mercapto, carbamido, carbamoyl, carboxyl, thioureido, thiocyanato, sulfonamido, C-ËœC6 alkyl, C2ËœC6 alkenyl, C1ËœC6 alkoxy, and aryl; each of R1 and R2, independently, is H, or C(O)Rd; and one of Ra and Rb is thienyl, furyl, pyridinyl, indolyl, 2-oxo-indolyl, aryl, alkyl, or alkyl substituted with aryl, and each of the other of Ra and Rb, and Rc, and Rd, independently, is H, alkyl, or aryl; in which alkyl and aryl are unsubstituted or substituted with one or more substitutents selected from the group consisting of halogen, hydroxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, cyano, nitro, mercapto, carbamido, carbamoyl, carboxyl, thioureido, thiocyanato, sulfonamido, C1ËœC6 alkyl, C2ËœC6 alkenyl, C1ËœC6 alkoxy, and aryl.