Patent ID: 7074890
Filing Date: 2006-07-11
Classification: A61K,A61P,C07K

Abstract:
1. A process for preparing a compound of formula I: wherein R R R or a salt thereof; the process comprising: (a) combining vancomycin or a salt thereof, with a compound of formula II: wherein R (b) acidifying the reaction mixture from step (a) with an acid; (c) contacting the reaction mixture from step (b) with a reducing agent to form a compound of formula III: or a salt thereof; (d) reacting the compound of formula III with an amine to provide a compound of formula IV: or a salt thereof; and wherein steps (a), (b), (c) and (d) are conducted in the same reaction mixture without isolation of the intermediate from step (a), (b) or (c); (e) reacting the compound of formula IV with formaldehyde and a compound of formula V: in the presence of a base to provide a compound of formula I, or a salt thereof.