Patent ID: 7244447
Filing Date: 2007-07-17
Classification: A61K,Y10S

Abstract:
1. A composition of matter useful for the delivery of a nonsteroidal anti-inflammatory drug through a body surface, comprising a formulation comprising: (a) a therapeutically effective amount of a nonsteroidal anti-inflammatory drug; (b) a hydroxide-releasing agent in an amount effective to enhance the flux of the drug through the body surface without causing damage thereto and effective to provide a pH in the range of approximately 8.0 to 13 at the body surface, during drug administration; and wherein the amount of hydroxide-releasing agent in the formulation is the total of (a) the amount required to neutralize any acidic species in the formulation plus (b) an amount equal to approximately 0.5 to 25.0 wt % of the formulation; and (c) a pharmaceutically acceptable carrier suitable for topical or transdermal drug administration, wherein: the composition is provided in a transdermal patch comprising a laminated structure that is to be affixed to the skin, the structure comprising a drug reservoir comprising the formulation contained within a polymeric matrix of a pharmaceutically acceptable adhesive material that serves to affix the system to the skin during drug delivery, and wherein the hydroxide-releasing agent comprises an inorganic hydroxide selected from the group consisting of sodium hydroxide and potassium hydroxide.