Patent ID: 7807638
Filing Date: 2010-10-05
Classification: A61K,A61P,C12N,C12Y

Abstract:
1. A method for treating a mammal having a disease or a disorder wherein blood clot formation is desirable, comprising administering to a mammal in need thereof an effective amount of a recombinant Factor VII (FVII) or Factor VIIa (FVIIa) polypeptide variant, said variant comprising the amino acid sequence shown in SEQ ID NO:1 with six amino acid substitutions, said six amino acid substitutions consisting of a glutamic acid residue substituted for the arginine residue in position 36, a glutamine residue substituted for the proline residue in position 10, a glutamic acid residue substituted for the lysine residue in position 32, a glutamic acid residue substituted for the alanine residue in position 34, an asparagine residue substituted for the threonine residue in position 106, and an asparagine residue substituted for the valine residue in position 253 of SEQ ID NO:1, wherein said disease or disorder is selected from the group consisting of a hemorrhage, gastrointestinal bleeding, uncontrolled bleeding, bleeding in a mammal undergoing transplantation or resection or surgery, variceal bleeding, thrombocytopenia and hemophilia.