Patent ID: 8536174
Filing Date: 2013-09-17
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): wherein: A is present, G is selected from hydrogen, C wherein C wherein C R R L is absent or C D is aryl (other than naphthalen-2-yl), C wherein aryl and heteroaryl are optionally substituted with one, two, three or four substitutents independently selected from the group consisting of C provided that D is other than 2-hydroxy-5-chloro-phenyl, 3-methoxy-phenyl, 4-ethyl-phenyl, 6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl-methyl, cyclohex-3-enyl, 2,6-dichloro-phenyl and 2-chloro-4-fluoro-phenyl; A is a-4 wherein, the lower portion of A is attached, relative to the nitrogen atom of Formula (I), to the 4 or 5 position on the benzene ring portion of Formula (I); wherein a-4 is optionally substituted with one to two C L provided that L R wherein phenyl is optionally substituted with (R wherein C R R wherein heterocyclyl is optionally substituted with one, two or three oxo substituents; B is C wherein when B is other than C wherein when B is selected from the group consisting of C provided that, when B is phenyl substituted at the 3,4-, 3,5- or 4,5- positions with an unbranched C provided that B is other than 3-hydroxy-4-methoxy-phenyl and 3-(n-propyloxy)-4-methoxy-phenyl; E is hydrogen, halogen, C wherein R X and Y are independently O or S; and enantiomers, diastereomers, tautomers, and pharmaceutically acceptable salts thereof.