Patent ID: 6187926
Filing Date: 2001-02-13
Classification: C07D

Abstract:
A process for producing a quinolone derivative represented by the formula (I): ##STR3##whereinA, B, C and D are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxyl, lower alkylcarbonyl, lower alkoxycarbonyl, lower alkylthio, lower alkylamino, di-lower alkylamino, halogen, trifluoromethyl and nitro, comprising:reacting a compound represented by the formula (II): ##STR4##wherein A, B, C and D are as defined above,with a formic acid ester in an aprotic solvent selected from the group consisting of aromatic hydrocarbons, ether solvents, acetonitrile and dimethylformamide, in the presence of a base, andadding a protic solvent to the reaction mixture.