Patent ID: 6531468
Filing Date: 2003-03-11
Classification: A61P,C07D

Abstract:
A compound of formula (I): or pharmaceutically acceptable salts thereof, wherein the group R1 and R2 are selected independently from H, (C1-C6)alkyl, (C1-C6)fluoroalkyl, F, Cl, W, I, cyano, nitro, Oâ€”(C1-C6)alkyl, Oâ€”(C1-C6)fluoroalkyl, â€”NHC(O)R4 and â€”OR5, where R4 and R5 are selected independently from H, (C1-C6)alkyl, and a 5- to 7-membered aryl or heteroaiyl ring, or R1 and R2 together with the atoms to which they are attached, form a carbocyclic 5- or 6-membered ring or a heterocyclic 5- or 6-membered ring; and R3 is selected from the group consisting of H, (C1-C6)alkyl, (CH2)m-aryl or (CH2)m-heteroaryl, wherein m is an integer from 1 to 4, each aryl or heteroaryl group optionally substituted with Cl, Br, CN, CF3, Oâ€”(C1-C6)alkyl, (C1-C6)alkyl, sulfonyl(C1-C6)alkyl, â€”CO(C1-C6)alkyl, â€”CONH2, â€”CONH(C1-C6)alkyl, â€”CON((C1-C6)alkyl)2, or CH(OH)(C1-C6)alkyl; with the proviso that neither R1 nor R2 can be H or methyl, when R3 is H or â€”(CH2)m-phenyl and when neither R1 nor R2 can be H or methyl when R3 is methyl.