Patent ID: 6753336
Filing Date: 2004-06-22
Classification: A61P,C07D

Abstract:
A compound of the formula: or a pharmaceutically acceptable salt thereof wherein:Q represents a group of the Formula: wherein A is C1-C5 alkylene optionally mono-, di, or trisubstituted with substituents independently chosen from C1-C3 alkyl, C1-C3 alkoxy, halogen, halo(C1-C3)alkyl, halo(C1-C3)alkoxy, hydroxy, amino, and mono- or di(C1-C3)alkylamino;R1, R2, R3, R4, R5, R6, R7, and R8 are the same or different and represent hydrogen, halogen, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di(C1-C6)alkyl amino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, â€”COOH, â€”SO2NH2, mono or dialkylsulfonamido, â€”C(O)NH2, or mono or di(C1-C6)alkylcarboxamido; R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, and R19 independently represent hydrogen or C1-C6 alkyl; W is Câ€”Ra where Ra represents hydrogen, hydroxy, C1-C6 alkoxy, C1-C6 alkyl or cyano; X represents halogen, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono or di(C1-C6)alkylamino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, â€”COOH, â€”CONH2, mono- or di(C1-C6)alkylcarboxamido, â€”SO2NH2, mono or di(C1-C6)alkylsulfonamido; Y is oxygen, sulfur, â€”S(O)â€”, or â€”SO2â€”; and Z is C1-C6 alkyl or mono, di or trifluoromethyl.