Patent ID: 6706725
Filing Date: 2004-03-16
Classification: A61K,A61P,A61Q,C07D

Abstract:
A compound of formula (I): in which:R1 represents a hydrogen atom, a CH3 radical or a radical â€”(CH2)sâ€”OR4, R2 represents a radical â€”(CH2)tâ€”OR5, s, t, R4 and R5 having the meanings given below,Xâ€”Y represents a bonding group selected from the bonding groups of formulae (a) to (i) below: R6 and W having the meanings given below,Z represents a ring selected from the rings of formulae (j) to (n) below: R7 and R8 having the meanings given below,it being understood that when Z represents the rings of formula (k), (l) or (m), then Xâ€”Y cannot represent a bonding group of formula (c) or (d), it being understood that when Z represents a ring of formula (n), then Xâ€”Y represents a bonding group of formula (c) or (d), R3 represents an alkyl chain containing from 4 to 8 carbon atoms substituted with one or more hydroxyl groups, it being possible for the hydroxyl groups to be protected in the form of acetoxy, methoxy or ethoxy, trimethylsilyloxy, tert-butyldimethylsilyloxy, tetrahydropyranyloxy and optionally also: substituted with one or more lower alkyl or cycloalkyl groups and/or substituted with one or more halogen atoms and/or substituted with one or more CF3 groups and/or in which one or more carbon atoms of the chain are replaced with oxygen, sulphur or nitrogen atoms, it being possible for the nitrogen atoms to be optionally substituted with lower alkyl radicals and/or in which one or more single bonds of the chain are replaced with one or more double and/or triple bonds, R3 being positioned on the ring para or meta to the bonding group Xâ€”Y, s and t, which may be identical or different, being 1 or 2, R4 and R5, which may be identical or different, represent a hydrogen atom, an acetyl radical, a benzoyl radical, a trimethylsilyl radical, a tert-butyldimethylsilyl radical or a tetrahydropyranyl radical, R6 represents a hydrogen atom or a lower alkyl radical, W represents an oxygen or sulphur atom or an â€”NHâ€” radical which can optionally be substituted with a lower alkyl radical, R7 represents a hydrogen atom or a lower alkyl radical, R8 represents a hydrogen atom, a lower alkyl radical or a halogen atom, and the optical and geometrical isomers of the said compounds of formula (I), and salts thereof.