Patent ID: 8753857
Filing Date: 2014-06-17
Classification: A61P,C12N,C12Y

Abstract:
1. A crystal comprising the pro form of a matrix metalloproteinase 9 (proMMP9), wherein the proMMP9 has the amino acid sequence comprising SEQ ID NO: 12, and wherein the crystal of the proMMP9 is in apo form or in complex with a chemical entity, wherein said chemical entity is a small-molecule allosteric processing inhibitor of the proMMP9, wherein said crystal forms in space group C2 having unit cell having dimensions selected from the group consisting of: the unit cell dimensions of a=90.3 (Å), b=73.2 (Å), c=77.5 (Å), β=106.3°, the unit cell dimensions of a=91.7 (Å), b=73.7 (Å), c=79.4 (Å), β=105.4°, the unit cell dimensions of a=90.7 (Å), b=73.0 (Å), c=78.2 (Å), β=104.6°, the unit cell dimensions of a=91.0 (Å), b=73.6 (Å), c=78.0 (Å), β=106° and the unit cell dimensions of a=90.0 (Å), b=77.1 (Å), c=75.0 (Å), β=105°.