Patent ID: 6630326
Filing Date: 2003-10-07
Classification: A61K,A61P,C07K,G01N,Y02A,Y10S

Abstract:
A mutant protein of human TGF&bgr; receptor RII substantially free of other human proteins, the mutant RII protein having a sequence encoded by RII cDNA altered by a mutation selected from the group consisting of a two base pair insertion of GT which occurs in a six base pair repeat sequence GTGTGT corresponding to nucleotides 1931-1936 of SEQ ID NO: 10, a deletion of one A base pair from a ten base pair poly A sequence corresponding to nucleotides 709 to 718 of SEQ ID NO: 10, and a deletion of two A base pairs from a ten base pair poly A sequence corresponding to nucleotides 709 to 718 of SEQ ID NO: 10.