Patent ID: 7276603
Filing Date: 2007-10-02
Classification: A61P,C07D

Abstract:
1. A compound selected from the group consisting of: 8-{4-[2-(1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-fluoroquinoline; 8-{4-[2-(1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloroquinoline; 8-{4-[2-(1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methylquinoline; 8-{4-[2-(1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methoxyquinoline; 8-{4-[2-(6-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(6-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-fluoro-quinoline; 8-{4-[2-(6-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(6-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(6-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(6-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(6-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(5-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(5-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(5-chloro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methoxy-quinoline; 8-{4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-fluoro-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methoxy-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-isopropyl-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methoxy-quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-fluoro-quinoline; 8-{4-[2-(1-benzofuran-3-yl)propyl]-1-piperazinyl}quinoline; 8-{4-[2-(1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-fluoro-quinoline; 8-{4-[2-(1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)propyl]-1-piperazinyl}quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-chloro-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)propyl]-1-piperazinyl}-6-methyl-quinoline; 8-{4-[2-(7-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 6-methoxy-8-{4-[2-(7-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 6-methyl-8-{4-[2-(7-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 8-{4-[2-(5-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 6-chloro-8-{4-[2-(5-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 6-methyl-8-{4-[2-(5-methoxy-1-benzofuran-3-yl)-1-methylethyl)piperazin-1-yl]quinoline; 8-{4-[4-cis-(1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-chloroquinoline; 8-{4-[4-trans(1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-chloroquinoline; 8-{4-[4-cis(1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-fluoroquinoline; 8-{4-[4-trans(1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-fluoroquinoline; 8-{4-[4-cis(1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-methoxyquinoline; 8-{4-[4-trans (1-benzothien-3-yl)cyclohexyl]-1-piperazinyl}-6-methoxyquinoline; 6-fluoro-8-{4-[4-cis(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 6-fluoro-8-{4-[4-trans(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 6-methoxy-8-{4-[4-cis(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 6-methoxy-8-{4-[4-trans(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 5-chloro-8-{4-[4-cis(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 5-chloro-8-{4-[4-trans(5-fluoro-1-benzothien-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 8-{4-[4-cis(1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}-5-fluoroquinoline; 8-{4-[4-trans(1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}-5-fluoroquinoline; 8-{4-[4-cis(1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}-6-fluoroquinoline; 8-{4-[4-trans(1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}-6-fluoroquinoline; 5-fluoro-8-{4-[4-cis(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 5-fluoro-8-{4-[4-trans(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 6-fluoro-8-{4-[4-cis(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 6-fluoro-8-{4-[4-trans(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 8-{4-[4-cis(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 8-{4-[4-trans(7-methoxy-1-benzofuran-3-yl)cyclohexyl]-1-piperazinyl}quinoline; 5-chloro-8-{4-[4-cis(7-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 5-chloro-8-{4-[4-trans(7-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 5-chloro-8-{4-[4-cis(5-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 5-chloro-8-{4-[4-trans(5-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 6-fluoro-8-{4-[4-cis(5-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 6-fluoro-8-{4-[4-trans(5-methoxy-1-benzofuran-3-yl)cyclohexyl]piperazin-1-yl}quinoline; 8-[4-(4-benzofuran-2-yl-yclohexyl)-piperazin-1-yl]-6-fluoro-quinoline; and pharmaceutically acceptable salts thereof.