Patent ID: 8932345
Filing Date: 2015-01-13
Classification: A61F,A61L

Abstract:
1. An implantable medical device having a coating on an abluminal surface extending from a proximal end to a distal end, the coating formed by the steps of: spraying droplets having a first average liquid droplet size and comprising a solution of a volatile solvent and a taxane therapeutic agent onto a first region of the abluminal surface; evaporating the volatile solvent to form a coating of the taxane therapeutic agent on the first region; spraying droplets having a second average liquid droplet size and comprising the solution of the volatile solvent and the taxane therapeutic agent onto a second region of the abluminal surface; wherein the second average liquid droplet size is greater than the first average liquid droplet size; and evaporating the volatile solvent to form a coating of the taxane therapeutic agent on the second region, wherein release of the taxane therapeutic agent from the first region in an aqueous medium is faster than release of the taxane therapeutic agent from the second region in the aqueous medium, and wherein the coating consists essentially of the taxane therapeutic agent and an antithrombotic agent on the first region and on the second region and does not include a polymer.