Patent ID: 6750204
Filing Date: 2004-06-15
Classification: A61P,C07H

Abstract:
A compound represented by the formula or a pharmaceutically acceptable salt, ester or prodrug thereof, whereinA is selected from the group consisting of (1) C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of; i. halogen; ii. aryl; iii. substituted aryl; iv. heterocyclic; v. substituted heterocyclic; vi. â€”Oâ€”R5, where R5 is selected from the group consisting of: a. hydrogen; b. aryl; c. substituted aryl; d. heterocyclic; and e. substituted heterocyclic; vii. â€”Oâ€”C1-C6-alkyl-R5; viii. â€”Oâ€”C1-C6-alkenyl-R5; ix. â€”Oâ€”C1-C6-alkynyl-R5; and x. â€”NR6R7, where R6 and R7 are each independently selected from the group consisting of: a. hydrogen; b. C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of: (I) halogen; (II) aryl; (III) substituted aryl; (IV) heterocyclic; and (V) substituted heterocyclic; c. C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of: (I) halogen; (II) aryl; (III) substituted aryl; (IV) heterocyclic; and (V) substituted heterocyclic; d. C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of: (I) halogen; (II) aryl; (III) substituted aryl; (IV) heterocyclic; and (V) substituted heterocyclic, and c. R6 R7 taken together with the nitrogen atom to which they are connected form a 3- to 7-membered ring which may optionally contain one or more functions selected from the group consisting of: (I) â€”Oâ€”; (II) â€”NHâ€”; (III) â€”N(C1-C6-alkyl)-; (IV) â€”N(aryl)-; (V) â€”N(heteroaryl)-; (VI) â€”Sâ€”; (VII) â€”S(O)â€”; (VIII) â€”S(O)2â€”; and (IX) â€”C(O)â€”; (2) â€”C(O)â€”R5; (3) â€”C(O)â€”C1-C6-alkyl-R5; (4) â€”C(O)â€”C1-C6-alkenyl-R5; (5) â€”C(O)â€”C1-C6-alkynyl-R5; (6) C1-C6-alkyl-Mâ€”R5, where M is â€”OC(O)â€”, â€”OC(O)Oâ€”, â€”OC(O)NR6â€”, â€”NR6C(O)â€”, â€”NR6C(O)Oâ€”, â€”NR6C(O)NR7â€”, â€”NR6C(N)NR7â€” or S(O)nâ€”, where n=0, 1 or 2; (7) â€”C2-C6-alkenyl-Mâ€”R5; and (8) â€”C2-C6-alkynyl-Mâ€”R5; B, C, and D are each independently selected from the group consisting of: (1) hydrogen; (2) halogen; (3) C1-C6-alkyl. (4) aryl; (5) substituted aryl; (6) heterocyclic; (7) substituted heterocyclic; or (8) Oâ€”R5; or in the alternative B and C taken together are selected from the group consisting of: (1)&boxH;O; (2) &boxH;Nâ€”Oâ€”R5; and (3) &boxH;Nâ€”Nâ€”R6R7; or in the alternative B and D taken together with the carbon atoms to which they are attached form a cyclic moiety selected from the group consisting of: and(4) a 4- to 8-membered ring which may optionally contain one or more functions selected from the group consisting of: i. â€”Oâ€”; ii. â€”NHâ€”; iii. â€”N(C1-C6-alkyl)-; iv. â€”N(aryl)-; v. â€”N(heteroaryl)-; vi. â€”Sâ€”; vii. â€”S(O)â€”; viii. â€”S(O)2â€”; and ix. â€”C(O)â€”; R1 is selected from the group consisting of: (1) hydrogen; (2) R3, where R3 is C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of: i. halogen; ii. aryl; iii. substituted-aryl; iv. heteroaryl; v. substituted-heteroaryl; vi. â€”Oâ€”C1-C6-alkyl-R5; and vii. â€”Nâ€”R6R7; (3) C(O)â€”R4, where R4 is hydrogen or R3; (4) â€”C(O)Oâ€”R3; and (5) â€”C(O)Nâ€”R6R7; W is selected from the group consisting of: (1) hydrogen; (2) halogen; (3) C1-C6-alkyl; (4) C2-C6-alkenyl; and (5) C2-C6-alkynyl; and Rp1 is hydrogen or a hydroxy protecting group.