Patent ID: 6395746
Filing Date: 2002-05-28
Classification: A61K,A61P

Abstract:
A method of treating or preventing ophthalmic, otic or nasal infections and attendant inflammation, which comprises topically applying a therapeutically effective amount of a topical ophthalmic, otic or nasal pharmaceutical composition to the affected tissues, said composition comprising one or more compounds of the formula: whereinR1 is hydrogen, a pharmaceutically acceptable cation, or (C1-C6) alkyl; Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl; W is hydrogen, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy, NH2 or NHCH3; A is CH, CF, CCl, COCH3, Câ€”CH3, Câ€”CN or N; or A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and R2 is wherein:R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH3, CH2NH2, CH2NHCH3 or CH2NHC2H5, and R5, R6, R7, and R9 may also independently be NH2, NHCH3 or NHC2H5, provided that not more than three of R3, R4, R5, R6, R7, R9, R10 and R25 are other than hydrogen, and if three of these substituents are not hydrogen, at least one of them is methyl; or a prodrug of a compound of formula (I) having a free amino group, or a pharmaceutically useful hydrate or salt of a compound of formula (I); an anti-inflammatory effective amount of a steroidal or non-steroidal anti-inflammatory agent; and a pharmaceutically acceptable vehicle therefor.