Patent ID: 6972288
Filing Date: 2005-12-06
Classification: A61K,A61P,C07D

Abstract:
1. A compound of the formula wherein R R R X denotes a nitrogen atom, A denotes an oxygen atom or an —NH— group optionally substituted by a C B denotes a carbonyl or sulphonyl group, C denotes a 1,3-allenylene, 1,1 or 1,2-vinylene group which may be substituted in each case by one or two methyl groups or by a trifluoromethyl group, an ethynylene group or a 1,3-butadien-1,4-ylene group optionally substituted by 1 to 4 methyl groups or by a trifluoromethyl group, D denotes an alkylene, —CO-alkylene or —SO a —CO—O-alkylene, —CO—NR or, if D is bound to a carbon atom of the group E, it may also denote a bond or, if D is bound to a nitrogen atom of the group E, it may also denote a carbonyl or sulphonyl group, E denotes an —(R a 4- to 7-membered alkyleneimino group which may be substituted by an R a 4- to 7-membered alkyleneimino group which is substituted by two R a piperazino or homopiperazino group which is substituted in the 4 position by the group R a piperazino or homopiperazino group which is substituted in the 4 position by the group R a piperazino or homopiperazino group which is substituted in each case in the 4 position by an R a piperazino or homopiperazino group which is substituted in the 4 position by an R a morpholino or homomorpholino group which is substituted in each case by an R a morpholino or homomorpholino group which is substituted by two R a pyrrolidinyl, piperidinyl or hexahydroazepinyl group substituted in the 1 position by the group R a pyrrolidinyl, piperidinyl or hexahydroazepinyl group substituted in the 1 position by the group R a pyrrolidinyl, piperidinyl or hexahydroazepinyl group substituted in the 1 position by an R a pyrrolidinyl, piperidinyl or hexahydroazepinyl group substituted in the 1 position by an R a morpholino or thiomorpholino group which is substituted in the 2 position by a C a morpholino or thiomorpholino group which is substituted in the 2 and 6 positions by a C a C a C an R or D together with E denotes an R F and G together denote a hydrogen atom, a C a C whilst by the aryl moieties mentioned in the definitions of the abovementioned groups is meant a phenyl group which in each case may be monosubsituted by R two groups R or a tautomer or salt thereof.