Patent ID: 8435942
Filing Date: 2013-05-07
Classification: A61K

Abstract:
1. A method of formulating a topical transdermal polypeptide composition comprising: providing a polyglycol or a mixture of polyglycols; shaving polyenylphosphatidylcholine-enriched phosphatidylcholine into the polyglycol to form a phosphatidylcholine solution; and mixing the phosphatidylcholine solution until the phosphatidylcholine solution is clear; warming the phosphatidylcholine solution to 40° C. and milling the warmed solution; combining siloxylated polyether and polydimethylsiloxane to form a fluid; adding the fluid to the warmed solution carrier and milling until the solution is clear; adding methyl paraben to the solution and milling until the methyl paraben dis-solves in the solution; warming water to 40° C. and adding the warmed water slowly to the solution; ceasing milling of the solution and sweeping the solution to cool to room temperature to form a multilamellar liquid crystal carrier; mixing a polypeptide solution into the multilamellar liquid crystal carrier to entrap the polypeptide solution within the carrier to form a topical transdermal polypeptide composition in which the polypeptide solution is stabilized at room temperature up to at least 22 weeks.