Patent ID: 7662830
Filing Date: 2010-02-16
Classification: A61P,C07D

Abstract:
1. A compound or salt selected from the group consisting of: 2-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-morpholin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 2-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-morpholin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 2-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-morpholin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; [2-(6-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-pyridin-3-yloxy)-ethyl]-dimethyl-amine; 3-Chloro-2-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-isonicotinic acid; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid methyl ester; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-ylmethyl)-methyl-amine; C-(5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methylamine; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-ylmethyl)-dimethyl-amine; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid methyl ester; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinic acid; (6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridin-3-yl)-methanol; (6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-pyridin-3-yl)-methanol; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-acetic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 5-Chloro-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Chloro-6-{4-[6-(5-chloro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Chloro-6-{4-[6-(2-isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinamide; 5-Chloro-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; (5-Chloro-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Chloro-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Chloro-6-{4-[6-(5-chloro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Chloro-6-{4-[6-(2-isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(5-chloro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(2-isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinic acid ethyl ester; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid ethyl ester; 6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid ethyl ester; 6-{4-[2-Dimethylamino-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid ethyl ester; (5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridin-3-yl)-methanol; (6-{4-[2-Dimethylamino-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridin-3-yl)-methanol; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; (5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol; (6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-pyridin-3-yl)-methanol; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinic acid; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; 6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 6-{4-[2-Dimethylamino-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 6-{4-[2-Dimethylamino-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinamide; 6-[4-(2-Dimethylamino-6-phenyl-pyrimidin-4-yl)-3-(R)-methyl-piperazin-1-yl]-5-methyl-nicotinamide; 6-[4-(2-Dimethylamino-6-pyridin-4-yl-pyrimidin-4-yl)-3-(R)-methyl-piperazin-1-yl]-5-methyl-nicotinamide; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-m-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 5-Methyl-6-{4-[2-(2-methyl-pyrrolidin-1-yl)-6-pyridin-4-yl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 6-{4-[6-(2-Isopropyl-pyridin-4-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridine-3-carboximidamide; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-acetic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-(R)-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 2-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidine-5-carboxylic acid amide; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(S)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-acetonitrile; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-acetic acid; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(3-(R)-methyl-morpholin-4-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; (6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridin-3-yl)-acetic acid; N-Cyclopropyl-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinamide; N-cyclobutyl-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; N-Cyclopentyl-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N-(2-methoxyethyl)-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N-(3-methoxypropyl)-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methyl-N-(tetrahydrofuran-2-ylmethyl)nicotinamide; N-(3-ethoxypropyl)-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; N-benzyl-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; N-(4-fluorobenzyl)-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N-(4-methoxybenzyl)-5-methylnicotinamide; N-[3-(dimethylamino)propyl]-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N-(2-methoxy-1-methylethyl)-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methyl-N-(2-thienylmethyl)nicotinamide; N-(2-ethoxyethyl)-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methyl-N-(2,2,2-trifluoroethyl)nicotinamide; N-benzyl-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N,5-dimethylnicotinamide; 4-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)-6-{4-[3-methyl-5-(pyrrolidin-1-ylcarbonyl)pyridin-2-yl]piperazin-1-yl}pyrimidine; 4-(4-fluorophenyl)-6-{4-[3-methyl-5-(piperidin-1-ylcarbonyl)pyridin-2-yl]piperazin-1-yl}-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-[(6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridin-3-yl)carbonyl]morpholine; 4-(4-fluorophenyl)-6-(4-{3-methyl-5-[(4-methylpiperidin-1-yl)carbonyl]pyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 1-[(6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridin-3-yl)carbonyl]azepane; 4-[(6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridin-3-yl)carbonyl]thiomorpholine; 4-(4-fluorophenyl)-6-(4-{3-methyl-5-[(2-methylpiperidin-1-yl)carbonyl]pyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; N-cyclohexyl-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N,5-dimethylnicotinamide; 4-(4-fluorophenyl)-6-(4-{3-methyl-5-[(4-phenylpiperidin-1-yl)carbonyl]pyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-fluorophenyl)-6-(4-{3-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]pyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-fluorophenyl)-6-[4-(5-{[4-(2-methoxyethyl)piperazin-1-yl]carbonyl}-3-methylpyridin-2-yl)piperazin-1-yl]-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-{5-[(4-cyclopentylpiperazin-1-yl)carbonyl]-3-methylpyridin-2-yl}piperazin-1-yl)-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-{5-[(4-acetylpiperazin-1-yl)carbonyl]-3-methylpyridin-2-yl}piperazin-1-yl)-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-fluorophenyl)-6-(4-{3-methyl-5-[(2-methylpyrrolidin-1-yl)carbonyl]pyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; N-[2-(dimethylamino)ethyl]-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N,5-dimethylnicotinamide; N-[3-(dimethylamino)propyl]-6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N,5-dimethylnicotinamide; 6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-N,5-dimethyl-N-(1-methylpyrrolidin-3-yl)nicotinamide; 1-[(6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridin-3-yl)carbonyl]-N,N-dimethylpyrrolidin-3-amine; N-{1-[(6-{4-[6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}-5-methylpyridin-3-yl)carbonyl]pyrrolidin-3-yl}acetamide; 4-(4-fluorophenyl)-6-(4-{5-[(4-methoxypiperidin-1-yl)carbonyl]-3-methylpyridin-2-yl}piperazin-1-yl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 4-(4-{5-[(4,4-difluoropiperidin-1-yl)carbonyl]-3-methylpyridin-2-yl}piperazin-1-yl)-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(3-(R)-methyl-morpholin-4-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridine-2-carboxylic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-pyridine-2-carboxylic acid amide; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 2-(5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-propan-2-ol; 1-(5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-ethanol; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-N-(2-hydroxy-ethyl)-nicotinamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(3-(R)-methyl-morpholin-4-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 2-(5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyridin-3-yl)-acetamide; 6-{4-[6-(4-Fluoro-phenyl)-2-(isopropyl-methyl-amino)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 6-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; (5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-(2-(S)-hydroxymethyl -pyrrolidin-1-yl)-methanone; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(isopropyl-methyl-amino)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(3-(R)-methyl-morpholin-4-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 5-Chloro-6-{4-[6-(4-fluoro-phenyl)-2-(isopropyl-methyl-amino)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 6-{4-[6-(3-Chloro-4-fluoro-phenyl)-2-(isopropyl-methyl-amino)-pyrimidin-4-yl]-piperazin-1-yl}-5-methyl-nicotinic acid; 4-(4-Fluoro-phenyl)-6-[2-(R)-methyl-4-(3-methyl-5-oxazol-2-yl-pyridin-2-yl)-piperazin-1-yl]-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine; 5-Chloro-6-{4-[2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinic acid; 4-(4-Fluoro-phenyl)-6-{2-(R)-methyl-4-[3-methyl-5-(1H-tetrazol-5-yl)-pyridin-2-yl]-piperazin-1-yl}-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine; 5-Chloro-6-{4-[2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 5-Chloro-N-(2-hydroxy-ethyl)-6-{4-[2-(2-(S)-hydroxymethyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-nicotinamide; 5-Chloro-N-(2-hydroxy-ethyl)-6-{3-(R)-methyl-4-[2-(2-(R)-methyl-pyrrolidin-1-yl)-6-phenyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; 5-Methyl-6-{3-(R)-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-6-p-tolyl-pyrimidin-4-yl]-piperazin-1-yl}-nicotinic acid; 4-(4-Fluoro-phenyl)-6-{4-[5-(1H-imidazol-2-yl)-3-methyl-pyridin-2-yl]-2-(R)-methyl-piperazin-1-yl}-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(S)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; N-(2-Hydroxy-ethyl)-5-methyl-6-{3-(R)-methyl-4-[6-(6-methyl-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-nicotinamide; (5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-piperidin-1-yl-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-pyridin-3-yl)-methanol; 5-Chloro-6-{4-[6-(3-chloro-4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-2-(R)-methyl-piperazin-1-yl}-nicotinic acid ethyl ester; methyl nicotinic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-5-trifluoromethyl-nicotinic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-trifluoromethyl-nicotinic acid; 2-[6-((3R)-4-{6-(4-fluorophenyl)-2-[(2R)-2-methyl-1-pyrrolidinyl]-4-pyrimidinyl}-3-methyl-1-piperazinyl)-5-methyl-3-pyridinyl]ethanol; 2-{[6-((3R)-4-{6-(3-chloro-4-fluorophenyl)-2-[(2R)-2-methyl-1-pyrrolidinyl]-4-pyrimidinyl}-3-methyl-1-piperazinyl)-5-methyl-3-pyridinyl]oxy}ethanol; 2-{[5-chloro-6-((3R)-4-{6-(3-chloro-4-fluorophenyl)-2-[(2R)-2-methylpyrrolidin-1-yl]pyrimidin-4-yl}-3-methylpiperazin-1-yl)pyridin-3-yl]oxy}ethanol; 2-{[6-((3R)-4-{6-(4-fluorophenyl)-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl}-3-methylpiperazin-1-yl)-5-methylpyridin-3-yl]oxy}ethanol; 2-[5-chloro-6-((3R)-4-{6-(3-chloro-4-fluorophenyl)-2-[(2R)-2-methylpyrrolidin-1-yl]pyrimidin-4-yl}-3-methylpiperazin-1-yl)pyridin-3-yl]ethanol; 2-[5-chloro-6-((3R)-4-{6-(3-chloro-4-fluorophenyl)-2-[(2R)-2-methylpyrrolidin-1-yl]pyrimidin-4-yl}-3-methylpiperazin-1-yl)pyridin-3-yl]-N,N-dimethylethanamine; and 2-[5-chloro-6-((3R)-4-{6-(3-chloro-4-fluorophenyl)-2-[(2R)-2-methylpyrrolidin-1-yl]pyrimidin-4-yl}-3-methylpiperazin-1-yl)pyridin-3-yl]-N-methylethanamine; and pharmaceuticallv acceptable salts thereof.