Patent ID: 6492364
Filing Date: 2002-12-10
Classification: A61K,A61P,C07D,Y02P

Abstract:
A triazolo derivative of the Formula I: wherein,W represents a carbon atom or a nitrogen atom, X represents a C2-C6 straight chain alkyl group, a C3-C8 branched alkyl group, a C2-C6 fluoroalkyl group, Formula II: wherein m and n represent integers of 0 to 6, and â€”(CH2)nâ€” is bound to the position of any one of 2-, 3- and 4-position in the cyclohexane ring or Formula III: wherein m and n represent integers of 0 to 6, and â€”(CH2)nâ€” is bound to the position of any one of 2-, 3- and 4-position in the benzene ring; Y represents a carbon atom or a nitrogen atom; --- represents a single bond or a double bond; Z1 and Z2, which may or may not simultaneously exist, each represents C6-C18 substituted or non-substituted cyclohexyl group, indole-3-yl group, imidazoyl group, furyl group, thienyl group, pyrrolyl group, pyridyl group or QCR6R7R8, with the proviso that in cases where Z1 and Z2 represent QCR6R7R8, Q may or may not exist, and when Q exists, Q is selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom; R6 represents hydrogen or hydroxyl group; R7 and R8, which may be the same or different, represent hydrogen, C1-C6 straight alkyl group, C3-C8 branched alkyl group, or one selected from the group consisting of C6-C16 substituted or non-substituted phenyl group, C10-C16 substituted or non-substituted naphthyl group and C6-C16 substituted or non-substituted cycloalkyl group, which phenyl group, naphthyl group or cycloalkyl group is bound through C0-C6 methylene chain; V represents a carbon atom or a nitrogen atom; R1 represents C1-C6 straight alkyl group or aryl group; R2 and R3, which may be the same or different, each is selected from the group consisting of hydrogen, C1-C6 straight alkyl group, C1-C6 straight alkoxyl group, C3-C8 branched alkyl group, C3-C8 branched alkoxyl group, hydroxyl group, chloro, bromo, fluoro, amino group, monoalkylamino group in which the alkyl group has 1 to 6 carbon atoms, dialkylamino group in which each alkyl group has 2 to 6 carbon atoms, trifluoromethyl group, and nitro group; in cases where V and W are carbon atoms and where V and W are bound through double bond, R4 does not exist, and R5 represents hydrogen, C1-C6 straight alkyl group, C1-C6 straight alkoxyl group, C3-C8 branched alkyl group, C3-C8 branched alkoxyl group, or represents one selected from the group consisting of C6-C16 substituted or non-substituted phenyl group, C10-C16 substituted or non-substituted naphthyl group and C6-C16 substituted or non-substituted cycloalkyl group, which phenyl group, naphthyl group or cycloalkyl group is bound through C0-C6 methylene chain; in cases where V is nitrogen atom and W is carbon atom and where V and W are bound through double bond, both R4 and R5 do not exist; in cases where V is carbon atom, W is nitrogen atom or carbon atom, and V and W are bound through single bond, R4 and R5 cooperatively represent oxo group; wherein the substituent(s) in said substituted phenyl group, substituted naphthyl group and substituted cycloalkyl group is (are) 1 to 5 C1-C6 straight alkyl group(s), C3-C6 branched alkyl group(s), phenyl group(s), phenoxy group(s), naphthyl group(s), cyclopentyl group(s) or cyclohexyl group(s)) or a pharmaceutically acceptable salt thereof.