Patent ID: 9220746
Filing Date: 2015-12-29
Classification: A61K,A61P,C07K

Abstract:
1. A method for enhancing bone formation and inhibiting bone resorption simultaneously in a subject in need thereof, comprising administering to the subject a peptide selected from the group consisting of: a) a peptide consisting of the amino acid sequence KHHLGLEEPKKLR (SEQ ID NO:1), plus an additional 0, 1, 2 or 3 amino acid residues at the carboxy terminus; b) a peptide consisting of the amino acid sequence KHHLGLEEPKK (SEQ ID NO:2), plus an additional 0, 1, 2 or 3 amino acid residues at the carboxy terminus; c) a peptide consisting of the amino acid sequence HLGLEEPKKLR (SEQ ID NO:3), plus an additional 0, 1, 2 or 3 amino acid residues at the carboxy terminus; d) a peptide consisting of the amino acid sequence KHHLGLEEPKKLR (SEQ ID NO:1), wherein the K or H at positions 1, 2, or 3 is substituted with arginine or lysine, the L at positions 4 or 6 is substituted with I or V, the K at positions 10 or 11 is substituted with H or R, the L at position 12 is substituted with I or V and/or the R at position 13 is substituted with K or H, plus an additional 0, 1, 2 or 3 amino acid residues at the carboxy terminus; e) a pharmaceutically acceptable salt of any of the peptides of (a) through (d); and f) any combination of (a) through (e) above, in an amount effective to enhance bone formation and inhibit bone resorption simultaneously in said subject.