Patent ID: 6127489
Filing Date: 2000-10-03
Classification: C07F,C08F

Abstract:
A method for preparing a resin-bound compound, wherein the compound is an aromatic carbocycle comprising an aromatic carbon atom and at least one substituent, X, A, B or C, said method comprising the steps of:(i) coupling the aromatic carbon to a polymeric resin support through a silane linker to give a resin-bound aryl silane intermediate of formula (I): ##STR9## wherein: R.sup.a and R.sup.b, independently from one another, are C.sub.1 to C.sub.6 alkyl;X, A, B and C are, independently from one another, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, C(O)R.sup.d, wherein R.sup.d is hydrogen or alkyl, t-butoxyaminocarbonyl, cyano, nitro, aryl, heteroaryl, arylalkyl, alkyl disulfide, aryl disulfide, acetal, fluorenylmethoxycarbonyl or orthoester group; andn is an integer from 2 to 20; and(ii) performing additional synthetic chemistry on at least one substituent, X, A, B or C, in order to modify said substituent, with the proviso that not all of substituents X, A, B or C are hydrogen and not all of X, A, B or C are alkyl.