Patent ID: 8349309
Filing Date: 2013-01-08
Classification: A61K,A61L,C08G

Abstract:
1. A method for synthesizing a pharmaceutically-active polymer, said method comprising reacting a biological coupling agent with a prepolymer in a step growth polymerization reaction, wherein said biological coupling agent has the general formula (III): wherein PBio comprises a radical of a biologically active agent linked to LINK A through a hydrolysable covalent bond and having at least one functional group to permit step growth polymerization with said prepolymer; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight formed from a diol or diamine and linked to each of said PBio fragments, wherein each PBio bears an equivalent functional group selected from hydroxyl, a primary amine, and secondary amine for polymerization with said prepolymer, and wherein said prepolymer is described by the formula: wherein