Patent ID: 6436978
Filing Date: 2002-08-20
Classification: A61K,C07D

Abstract:
A compound of formula; wherein;a) R1 is hydrogen, or alkyl or nil; where R1 is nil, bond (a) is a double bond; b) D is CR2 where R2 is selected from hydrogen; unsubstituted C1-C3 alkanyl; amino, hydroxy, mercapto; C1-C3 alkylthio or alkoxy; C1-C3 alkylamino or C1-C3 dialkylamino and halo; or when B is CR3, D may be N; c) B is CR3, S, O, SO or SO2; and wherein R3 is independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycioalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylarnino or C1-C3 dialkylamino and halo; d) R4, R5 and R6 are each independently selected from hydrogen: unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, eycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino; halo; and NHâ€”NHâ€”C(&boxH;NR10)NHR11 (guanidinylamino); wherein R10 and R11 are independently selected from hydrogen; methyl; and ethyl; and wherein one and only one of R4, R5 and R6 is guanidinyl amino; c) R7 is selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl, cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro, cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo; and onantiomers, optical isomers, stereoisomers, diastereomers, tautorners, addition salts, biohydrolyzable amides and esters, and pharmaceutical compositions containing such novel compounds, and the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.