Patent ID: 9156796
Filing Date: 2015-10-13
Classification: A61P,C07D

Abstract:
1. A compound of the formula I, wherein R′, R″, and R′″ are independently of each other H, halogen, CF R a) (C b) (C c) methylene-cyclohexyl; or d) phenyl, which is unsubstituted or mono-substituted by methyl or Cl; R a) a 5-membered heteroaryl which contains 1 or 2 identical or different ring heteroatoms selected from the group consisting of N, O and S, wherein said 5-membered heteroaryl is unsubstituted or mono-substituted by Cl or (C b) phenyl; c) (C d) tetrahydrofuranyl; R and R a) (C b) (C c) (C d) thienyl; or R are, together with the carbon atom to which they are attached, a 5- to 7-membered cycloalkyl ring, which is unsubstituted or mono-substituted by (C R R n is 0, 1 or 2; and Z is CO wherein v is 0 or 2; R R R and R a) H; b) (C c) (C wherein R d) (C wherein R R R R R e) (C f) (C g) (C x is 2; and R h) (C i) 8-methyl-8-aza-bicyclo[3.2.1]oct-3yl; j) 9-methyl-9-aza-bicyclo[3.3.1]non-3-yl; k) methylene-4-(octahydro-quinolizinyl); l) (C m) (C or R a) a four-, five- or six-membered heterocycloalkyl ring containing one heteroatom, which is the N atom to which R b) a six- or seven-membered heterocycloalkyl ring containing the N atom to which R R c) a 2,5-diaza-bicyclo[2.2.1]heptyl-ring, which is unsubstituted or substituted on the N atom in the 5-position by a substituent selected from the group consisting of (C R R R R R R R and R in any of its stereoisomeric forms, or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them.