Patent ID: 9044452
Filing Date: 2015-06-02
Classification: A61K,A61P

Abstract:
1. A method for treating a joint affected by pain, the method comprising injecting an agent comprising resiniferatoxin and a calcium salt dissolved in a physiologically suitable solvent locally into the intracapsular region or the bursa of the joint affected by pain, wherein the concentration of resiniferatoxin in the agent is between approximately 10 nmolar (nM) and 100 μmolar (μM), wherein the agent has a calcium ion concentration of greater than 2 mmolar, and wherein the agent is dissolved in a buffer solution with a pH higher than 7.6 wherein the concentration of resiniferatoxin (RTX) in the agent is such that neurolysis occurs to nociceptive nerve fibers in the joint, and wherein nociceptive nerve fibers in the joint are made insensitive to pain for a period of at least 14 days after the agent is injected into the intracapsular region or the bursa of the joint affected by pain.