Patent ID: 6503903
Filing Date: 2003-01-07
Classification: A61P,C07D

Abstract:
A method for treating a bacterial infection which comprises administering to a subject in need thereof a compound according to formula (I): wherein:R1 is H, C1-6alkyl or Arâ€”C1-6alkyl; R2 is H, C1-6alkyl, Arâ€”C0-6alkyl, HO-(CH2)nâ€” or Râ€²OC(O)â€”(CH2)nâ€”; R3 is Aâ€”C0-4alkyl, Aâ€”C2-4alkenyl, Aâ€”C2-4alkynyl, Aâ€”C3-4oxoalkenyl, Aâ€”C3-4oxoalkynyl, Aâ€”C1-4aminoalkyl, Aâ€”C3-4aminoalkenyl, Aâ€”C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R10 or R7; R5 is H, C1-6alkyl, Arâ€”C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R7 is â€”COR8, â€”COCRâ€²2R9, â€”C(S)R8, â€”S(O)kORâ€², â€”S(O)kNRâ€²Râ€³, â€”PO(ORâ€²), â€”PO(ORâ€²)2, â€”B(ORâ€²)2, â€”NO2, or tetrazolyl; R8 is â€”ORâ€², â€”NRâ€²Râ€³, â€”NRâ€²SO2Râ€², â€”NRâ€²ORâ€², or â€”OCRâ€²2CO(O)Râ€²; R9 is â€”ORâ€², â€”CN, â€”S(O)rRâ€², â€”S(O)kNRâ€²2, â€”C(O)Râ€², C(O)NRâ€²2, or â€”CO2Râ€²; R10 is H, halo, â€”OR11, â€”CN, â€”NRâ€²R11, â€”NO2, â€”CF3, CF3S(O)râ€”, â€”CO2Râ€², â€”CONRâ€²2, Aâ€”C0-6alkyl-, Aâ€”C1-6oxoalkyl-, Aâ€”C2-6alkenyl-, Aâ€”C2-6alkynyl-, Aâ€”C0-6alkyloxy-, Aâ€”C0-6alkylamnino- or Aâ€”C0-6alkyl-S(O)r; R11 is Râ€², â€”C(O)Râ€², â€”C(O)NRâ€²2, â€”C(O)ORâ€², â€”S(O)kRâ€², or â€”S(O)kNRâ€²2; Râ€² is H, C1-6alkyl, Arâ€”C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; Râ€³ is Râ€², â€”C(O)Râ€² or â€”C(O)ORâ€²; Râ€²â€³ is H, C1-6alkyl, Arâ€”C0-6alkyl, HOâ€”(CH2)2â€”, Râ€²C(O)â€”, (Râ€²)2NC(O)CH2â€” or Râ€²S(O)2â€”; X is H, C1-4alkyl, ORâ€², SRâ€², C1-4alkylsulfonyl, C1-4alkylsulfoxyl, â€”CN, N(Râ€²)2, CH2N(Râ€²)2, â€”NO2, â€”CF3, â€”CO2Râ€², â€”CON(Râ€²)2, â€”CORâ€”, â€”NRâ€²C(O)Râ€², F, Cl, Br, I, or CF3S(O)râ€”; k is 1 or 2; m is 1,2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.