Patent ID: 7560449
Filing Date: 2009-07-14
Classification: A61K,A61P

Abstract:
1. A method of treating demyelination in a subject, comprising the step of administering to a subject in need of such treatment an effective amount of at least one sterol absorption inhibitor or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one sterol absorption inhibitor is: Formula (I): or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein: Ar Ar X, Y and Z are independently selected from the group consisting of —CH R and R R q is 0 or 1; r is 0 or 1; m, n and p are independently selected from 0, 1, 2, 3 or 4; provided that at least one of q and r is 1, and the sum of m, n, p, q and r is 1, 2, 3, 4, 5 or 6; and provided that when p is 0 and r is 1, the sum of m, q and n is 1, 2, 3, 4 or 5; R R R R