Patent ID: 6121471
Filing Date: 2000-09-19
Classification: C07D

Abstract:
A method of forming a compound containing an amide bond, comprising the steps of:reacting an amine, a carboxylic acid, an amide coupling agent and a compound of the formula (1): ##STR11## where R.sup.1 is a group bearing a positive charge at pH 5-7; Y is a bond or a substituted or unsubstituted alkylene chain containing 1-10 carbon atoms and 0-2 heteroatoms selected from the group consisting of N, S and O; andX is a linker group selected from --CO-- or --SO.sub.2 --; for a time sufficient to produce an amide bond between the amine and the carboxylic acid; andisolating the compound containing the amide bond.