Patent ID: 6232321
Filing Date: 2001-05-15
Classification: A61P,C07D

Abstract:
A compound of structure VIII: ##STR21##wherein,R.sub.19 is: ##STR22##R.sub.11 and R.sub.12 are each independently a hydrogen or R.sub.4, with the proviso that that R.sub.11 and R .sub.12 are not both hydrogen; andR.sub.4 is (i) hydrogen, (ii) --CH(R.sub.d)--O--C(O)--Y--Z--(C(R.sub.e)(R.sub.f)).sub.p --T--Q, (iii) --C(O)--T--(C(R.sub.e)(R.sub.f)).sub.p --T--Q, or (iv) --C(O)--Z--(G--(C(R.sub.e)(R.sub.f)).sub.p --T--Q).sub.p ;wherein R.sub.d is a hydrogen, a lower alkyl, a cycloalkyl, an aryl, an arylalkyl, or a heteroaryl; Y is oxygen, sulfur, CH.sub.4 or NR,, wherein R.sub.1 is a hydrogen or a lower alkyl; R.sub.e and R.sub.f are each independently a hydrogen, a lower alkyl, a haloalkyl, an alkoxy, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, an amino, an alkylamino, an amido, an alkylamido, a dialkylamino, a carboxylic acid, a carboxylic ester, a carboxamido or --T--Q, or R.sub.e and R.sub.f taken together with the carbons to which they are attached are a carbonyl, a cycloalkyl, a heterocyclic ring or a bridged cycloalkyl; p is an integer from 1 to 10; T is independently a covalent bond, oxygen, sulfur or NH; G is a covalent bond, --T--C(O)--, --C(O)--T-- or T; Z is a covalent bond, a lower alkyl, a haloalkyl, a cycloalkyl, an aryl, a heteroaryl, an arylalkyl, a heteroalkyl, an arylheterocyclic ring or (C(R.sub.e)(R.sub.f)).sub.p ; and Q is --NO or --NO.sub.2,with the proviso that at least one of R.sub.4, R.sub.11 or R.sub.12 contains at least one --NO or --NO.sub.2 group.