Patent ID: 9218457
Filing Date: 2015-12-22
Classification: G16B,G16H

Abstract:
1. A method for building a molecular entity model comprising unknown drug target interactions identified via adverse event data, comprising: receiving, by an analyzer module executed by a processor of a computing device from a user, an identification of a first drug having one or more unknown target proteins; identifying, by the analyzer module from a medication information database stored in a computer-readable storage medium, a second drug related to the first drug; retrieving, by the analyzer module from an adverse event database representing physiological reactions from interaction of molecular entities with pharmaceutical compounds of drugs stored in the computer-readable storage medium, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug; generating, by the analyzer module, a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile; identifying, by the analyzer module from the adverse event database, a third drug having a fourth side effect profile comprising the third side effect profile; retrieving, by the analyzer module from the medication information database, one or more target proteins of the third drug not targeted by the second drug; and building, by the analyzer module, a molecular entity model with the retrieved one or more target proteins as potential target proteins of the first drug.