Patent ID: 6277871
Filing Date: 2001-08-21
Classification: C07D

Abstract:
A compound of Formula I ##STR6##or a pharmaceutically acceptable salt thereof, whereL.sup.1 is selected from(1) phenyl,(2) naphthyl,(3) dihydronaphthyl, and(4) tetrahydronaphthyl,where (1)-(4) can be optionally substituted with 1 or 2 substituents independently selected from(a) alkyl,(b) halogen,(c) perfluoroalkyl, and(d) --OR.sup.3 where R.sup.3 is selected from(a) hydrogen and(b) alkyl;R.sup.1 is hydrogen;R.sup.2 is selected from(1) alkyl where the alkyl can be optionally substituted with 1, 2, or 3 substituents independently selected from(a) --CO.sub.2 R.sup.4 where R.sup.4 is selected from(i) hydrogen,(ii) alkyl, and(iii) a carboxy-protecting groupand(b) --S(O).sub.t R.sup.7,where R.sup.7 is selected from(i) hydrogen,(ii) alkyl, and(iii) aryl,andZ is--C(O)R.sup.12 where R.sup.12 iswhere R.sup.16 is alkyl, where the alkyl is substituted with 1, 2, or 3 cycloalkyl substituents.