Patent ID: 6056939
Filing Date: 2000-05-02
Classification: A61K,Y10S

Abstract:
A compound of formula I having the structure or a pharmaceutically acceptable salt thereof ##STR23## wherein X--R.sup.1 --Y represent a first chelating group andR.sup.4 and R.sup.5 represent a second chelating group which is covalently linked toX--R.sup.1 --(R.sup.2 --R.sup.6, R.sup.3 --R.sup.7)--Y through R.sup.2 and R.sup.3,whereinX and Y are independently atoms which coordinate metal ions selected from the group consisting of N, O, S, and P;R.sup.1 is an aliphatic or an aromatic skeleton to which X and Y are covalently linked selected from the group consisting of straight-chain, branched, saturated or unsaturated hydrocarbons optionally substituted with oxygen, nitrogen, hydroxy or amino groups;R.sup.2 and R.sup.3 are independently amino, oxy, mercapto, imino, hydrazido, ester, ketone, thiourea, aminoacetyl; or a saturated or unsaturated hydrocarbon substituted with amino, amido, oxy, mercapto, imino, hydrazido, ester, ketone, thiourea or aminoacetyl;R.sup.4 and R.sup.5 are independently a ligand nucleus selected from the group consisting of a cyclic or a non-cyclic linear or branched hydrocarbon having one to 6 nitrogen atoms, one of which at least is substituted by one carboxylate, phosphonate, oximate, diketonate, azino or hydroxamate group, said ligand nucleus optionally having one to six oxygen, sulfur or phosphorous atoms; said R.sup.4 and R.sup.5 ligand nucleus forming a complex with a metal atom different from the metal atom formed with X--R.sup.1 --Y;R.sup.6 and R.sup.7 are independently H, or straight-chain, branched, saturated or unsaturated hydrocarbons; or straight-chain, branched, saturated or unsaturated hydrocarbons substituted with amino, amide, ester, imino or hydrazido;n is 1 to 35; andm is 1 to 10.