Patent ID: 6653347
Filing Date: 2003-11-25
Classification: A61P,C07C

Abstract:
A compound of the formula: wherein:R is selected from the group consisting of OH, SH, and NHSO2Rd; Rd is selected from the group consisting of NR6R7, alkyl, arylC1-4alkyl, arylC2-4 alkenyl, heteroaryl, hetroaryl-C1-4alkyl, heteroarylC2-4 alkenyl, heterocyclic, and heterocyclicC1-4 alkyl, wherein the aryl, heteoaryl and heterocyclic rings are all unsubstituted or substituted; R6 and R7 are, independently, hydrogen, or a C1-4 alkyl group, or R6 and R7 together with the nitrogen to which they are attached form a 5 to 7 member ring which ring may optionally contain an additional heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, the ring being optionally substituted; R1 is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, halosubstituted C1-10 alkyl, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, halosubstituted C1-10 alkoxy, azide, (CR8R8)q S(O)tR4, hydroxy, hydroxy C1-4alkyl, aryl, aryl C1-4 alkyl, aryloxy, aryl C1-4 alkyloxy, heteroaryl, heteroarylalkyl, heterocyclic, heterocyclic C1-4alkyl, heteroaryl C1-4 alkyloxy, aryl C2-10 alkenyl, heteroaryl C2-10 alkenyl, heterocyclic C2-10 alkenyl, (CR8R8)qNR4R5, C2-10 alkenyl C(O)NR4R5, (CR8R8)q C(O)NR4R5, (CR8R8)q C(O)NR4R10, S(O)3H, S(O)3R8, (CR8R8)q C(O)R11, C2-10 alkenyl C(O)R11, C2-10 alkenyl C(O)OR11(CR8R8)q C(O)OR12, (CR8R8)q OC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)q NHS(O)2R17, (CR8R8)q and S(O)2NR4R5; or two R1 moieties together form Oâ€”(CH2)sOâ€” or a 5 to 6 membered unsaturated ring; q is 0, or an integer having a value of 1 to 10; t is 0, or an integer having a value of 1 or 2; s is an integer having a value of 1 to 3; R4 and R5 are independently selected from the group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, optionally substituted aryl C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl C1-4alkyl, heterocyclic, and heterocyclicC1-4 alkyl; or R4 and R5 together with the nitrogen to which they are attached form a 5 to 7 member ring which optionally comprises an additional heteroatom selected from oxygen, nitrogen and sulfur; Y is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, halosubstituted C1-10 alkyl, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, halosubstituted C1-10 alkoxy, azide, (CR8R8)q S(O)tR4, hydroxy, hydroxyC1-4alkyl, aryl, aryl C1-4 alkyl, aryloxy, arylC1-4 alkyloxy, heteroaryl, heteroarylalkyl, heteroaryl C1-4 alkyloxy, heterocyclic, heterocyclic C1-4alkyl, aryl C2-10 alkenyl, heteroaryl C2-10 alkenyl, heterocyclic C2-10 alkenyl, (CR8R8)q NR4R5, C2-10 alkenyl C(O)NR4R5, (CR8R8)q C(O)NR4R5, (CR8R8)q C(O)NR4R10, S(O)3H; S(O)3R8, (CR8R8)q C(O)R11, C2-10 alkenyl C(O)R11, C2-10 alkenyl C(O)OR11, C(O)R11, (CR8R8)q C(O)OR12, (CR8R8)q OC(O)R11, (CR8R8)q NR4C(O)R11, (CR8R8)q NHS(O)2Rd, and (CR8R8)q S(O)2NR4R5; or two Y moieties together form Oâ€”(CH2)sOâ€” or a 5 to 6 membered unsaturated ring; n is an integer having a value of 1 to 5; m is an integer having a value of 1 to 4; R8 is hydrogen or C1-4 alkyl; R10 is C1-10 alkyl C(O)2R8; R11 is selected from the group consisting of hydrogen, C1-4 alkyl, optionally substituted aryl, optionally substituted aryl C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroarylC1-4alkyl, optionally substituted heterocyclic, and optionally substituted heterocyclicC1-4alkyl; R12 is selected from the group consisting of hydrogen, C1-10 alkyl, optionally substituted aryl and optionally substituted arylalkyl; and R17 is selected from the group consisting of C1-4alkyl, aryl, arylalkyl, heteroaryl, heteroarylC1-4alkyl, heterocyclic, and heterocyclicC1-4alkyl, wherein the aryl, heteroaryl and heterocyclic rings are all optionally substituted.