Patent ID: 9096906
Filing Date: 2015-08-04
Classification: C12Q

Abstract:
1. A method of identifying a tissue of origin of a cancer sample, said method comprising: (a) obtaining a biological sample from a subject in need thereof, wherein the sample is of a cancer selected from the group consisting of cancer of unknown primary (CUP), primary cancer, and metastatic cancer; (b) measuring the level of nucleic acids consisting of SEQ ID NOS: 1; 2 or 156; 3-7; 9-12; 14-21; 23-27; 29-40; 42; 43; 44 or 191; 45-47; 49-51; 53-56; 57 or 202; 58; 59; 60 or 208; 61; 62 or 211; 64-69; and 146-148, and optionally at least one control nucleic acid, in the biological sample and comparing said level to a reference level using a classifier algorithm, wherein the tissue of origin of the cancer is identified in the subject if the level of the nucleic acids in the biological sample is above a reference threshold, wherein the measuring comprises contacting the sample with probes to the nucleic acids, wherein each probe consists of the complement of one of SEQ ID NOS: 1; 2 or 156; 3-7; 9-12; 14-21; 23-27; 29-40; 42; 43; 44 or 191; 45-47; 49-51; 53-56; 57 or 202; 58; 59; 60 or 208; 61; 62 or 211; 64-69; and 146-148, or of the optional at least one control nucleic acid, and wherein the probes are attached to a solid substrate; and (c) identifying the tissue of origin of the sample based on the level of the nucleic acids measured in step (b).