Patent ID: 6020483
Filing Date: 2000-02-01
Classification: C07H

Abstract:
A method for the preparation of a pyrimidine nucleoside modified at the 5- or 6-position of the pyrimidine ring comprising the steps of:reacting a pyrimidine starting material containing a leaving group attached to the 5- or 6-position of said pyrimidine starting material with a functionalized alkene having the formula: ##STR40## wherein Y is --CHROH;R is independently selected from the group consisting of H, alkyl, alkenyl and aryl; andn is an integer from 0-15in the presence of a palladium catalyst of the general formula PdL.sub.3 or PdL.sub.4, wherein L is a ligand of palladium to produce a pyrimidine nucleoside having the following formula: ##STR41## and isolating said modified nucleoside.