Patent ID: 7807178
Filing Date: 2010-10-05
Classification: A61K,A61P,A61Q,C07K

Abstract:
1. A method for treating peripheral limb ischemia or myocardial tissue ischemia in a patient in need thereof comprising: preparing an angiogenesis promoting formulation comprising as an active principle a mutein of the monomeric form of a mammalian type 1 Placental Growth Factor (PLGF-1) comprising a polypeptide sequence that differs from said mammalian PLGF-1 by a substitution or an elimination of a cysteine residue (Cys) in position 142 of a pre-protein wild type polypeptide sequence, corresponding to a Cys in position 125 of SEQ ID NO: 2, wherein the mutein retains an ability to form a PLGF-1 dimer, wherein said substitution or elimination prevents multimerization of said monomeric form, and wherein said mutein has angiogenic activity; and administering said formulation to the patient in order to treat the peripheral limb ischemia or the myocardial tissue ischemia.