Patent ID: 7662381
Filing Date: 2010-02-16
Classification: A61P,C07K

Abstract:
1. An isolated human monoclonal antibody, or an antigen-binding portion thereof, that specifically binds to human interferon alpha receptor 1 (IFNAR-1), wherein the antibody binds to IFNAR-1 with a Kd of 1×10 a) inhibits the biological activity of IFN-β; b) inhibits the activity of IFN α2b in a Daudi cell proliferation assay; c) inhibits the activity of IFN omega in a Daudi cell proliferation assay; d) inhibits IP-10 secretion by peripheral blood mononuclear cells induced by IFN α2b; e) inhibits IP-10 secretion by peripheral blood mononuclear cells induced by IFN omega; f) inhibits dendritic cell development mediated by Systemic Lupus Erythematosus plasma; and g) binds to a different epitope than murine monoclonal antibody 64G12 (ECACC Deposit No. 92022605).