Patent ID: 6107296
Filing Date: 2000-08-22
Classification: A61K

Abstract:
A method for the treatment and/or prevention of neurodegeneration arising from cerebral ischemia, which comprises administering to a patient in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof: ##STR7## wherein Y represents hydrogen or C.sub.1-6 alkyl; andZ represents C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.4-7 cycloalkenyl, aryl, C.sub.3-7 heterocycloalkyl, heteroaryl or di(C.sub.1-6)alkylamino, any of which groups may be optionally substituted; orY and Z are taken together with the two intervening carbon atoms to form a ring selected from C.sub.5-9 cycloalkenyl, C.sub.6-10 bicycloalkenyl, tetrahydropyridinyl, pyridinyl and phenyl, any of which rings may be optionally benzo-fused and/or substituted;R.sup.1 represents C.sub.3-7 cycloalkyl, phenyl, furyl, thienyl or pyridinyl, any of which groups may be optionally substituted; andR.sup.2 represents cyano(C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, propargyl, C.sub.3-7 heterocycloalkylcarbonyl(C.sub.1-6)alkyl, aryl(C.sub.1-6)alkyl or heteroaryl(C.sub.1-6)alkyl, any of which groups may be optionally substituted.