Patent ID: 6573292
Filing Date: 2003-06-03
Classification: A61K,A61P

Abstract:
A method for the treatment of chronic lymphocytic leukemia (CLL) in a patient, comprising administering to said patient a therapeutically effective amount of an indole or carbazole derivative of the formula: in which R1 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, alkoxyloweralkyl, lower cycloalkyl, phenyl, benzyl and 2-thienyl; R2 and R3 are the same or different and are each selected from the group consisting of hydrogen and lower alkyl; R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, lower alkyl, â€”NH2, â€”NHCHO, â€”NHCONH2, &boxH;NW, oxo, â€”OH and â€”OCH3, wherein w is hydroxy, alkoxy, aryloxy, carboxyalkyloxy, arylamino or alkylsulfonylamino; R6 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trifluoromethyl, hydroxy, lower alkoxy, trifluoroloweralkoxy, benzyloxy, araloxy, lower alkanoyloxy, acyl, amino, nitro, cyano, alkylimido, halo, mercapto, loweralkylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido and sulfamoyl; R7 is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl; X is selected from the group consisting of carbon, oxy and thio; Y is selected from the group consisting of carbonyl, in which each of R8, R9, R10, R11, R12 and R13 is hydrogen or lower alkyl; and Z is selected from the group consisting of hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino and phenylamino,or a pharmaceutically acceptable salt thereof.