Patent ID: 7682351
Filing Date: 2010-03-23
Classification: A61K

Abstract:
1. A method for infusing insulin intravenously to a subject to improve impaired hepatic glucose processing comprising the steps of: a. determining a baseline circulating glucose level of the subject and obtaining a subsequent circulating glucose level at least every 30 minutes, b. having the subject ingest a carbohydrate containing meal to cause a rise in circulating glucose levels, c. administering a series of insulin pulses until the rise in circulating glucose levels falls a threshold of at least 50 to 100 milligram per deciliter within two hours of administering an initial pulse of insulin; the series of insulin pulses having an amount of insulin in each pulse, an interval of time between pulses and a total time to deliver the series of pulses; d. repeating steps a, b and c at least one more time during a treatment day when said threshold is met; e. changing the amount of ingested carbohydrate of step b or changing the amount of insulin in each pulse, the interval of time between pulses or the total time to deliver the series of pulses of step c when said threshold is not met and repeating steps a, b, c and d;