Patent ID: 6448371
Filing Date: 2002-09-10
Classification: C08G

Abstract:
A process for the purification of poloxamers which contain aldehyde impurities said poloxamers having the formula HOâ€”[C2H4O]aâ€”[C3H6O]bâ€”[C2H4O]aâ€”H wherein a and b are the number of hydrophilic and hydrophobic chains respectively, whereby(i) the poloxamer(s) is dissolved in a solvent, which solvent may optionally contain an acid or a mixture of acids, (ii) if the solvent in which the poloxamer(s) has been dissolved is free from acid, acid is added; whereafter (iii) the aldehydes are removed by vaporizing at less than the melting temperature of said poloxamers.