Patent ID: 8668926
Filing Date: 2014-03-11
Classification: A61K,C07K,Y10T

Abstract:
1. A method for treating a non-cancerous skin disorder comprising: providing a thyroid hormone analog conjugated to a polymer via a linker, wherein the polymer is poly(lactic-co-glycolic) acid (PLGA), polylactide, polyglycolide, or co-polymers thereof, wherein said thyroid hormone analog is selected from the group consisting of tetraiodothyroacetic acid (TETRAC), triiodothyroacetic acid (TRIAC), thyroid antagonists and combinations thereof, wherein the linker is an ester linkage, anhydride linkage, thioether linkage, sulfhydryl linkage or ether linkage, wherein the conjugated thyroid hormone analog acts exclusively at the cell surface receptor and the conjugated thyroid hormone analog is a sufficient size to prevent the conjugated thyroid hormone analog from entering the cell; and administering the thyroid hormone analog conjugated to a polymer via a linker to a portion of the skin affected by the non-cancerous skin disorder.