Patent ID: 7705016
Filing Date: 2010-04-27
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A method of reducing food intake in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a small molecule capable of inhibiting carnitine palmitoyl transferase 1 (CPT1) in the brain of a mammal, wherein the pharmaceutical composition is administered in an amount and manner effective to reduce food intake in the mammal, wherein the pharmaceutical composition is administered to the brain such that the small molecule enters the hypothalamus or the pharmaceutical composition is administered such that the small molecule crosses the blood brain barrier, and wherein the small molecule capable of inhibiting CPT1 is 2-tetradecylglydate (TDGA) or (R)-N-(tetradecylcarbamoyl)-aminocarnitine.