Patent ID: 6414021
Filing Date: 2002-07-02
Classification: A61F,A61K,A61P,Y10S

Abstract:
A process for maintaining an acceptable intraocular pressure during ocular surgery in an eye of a patient which comprises infusing into the eye an ophthalmic surgical infusion or rinsing solution containing an effective amount for maintaining acceptable intraocular pressure of a compound of the formula (I): wherein W1, W2 and W3 are carbon or oxygen atoms, L, M and N are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, or oxo, wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have one or more double bond(s); A is â€”CH2OH, â€”COCH2OH, â€”COOH or its functional derivative; B is â€”CH2â€”CH2â€”, â€”CH&boxH;CHâ€” or â€”Câ‰¡Câ€”; Z is wherein R4 and R5 are hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy or hydroxy(lower)alkyl, wherein R4 and R5 are not hydroxy and lower alkoxy at the same time; R1 is a divalent saturated or unsaturated lower-medium aliphatic hydrocarbon residue, which is unsubstituted or substituted by halogen, oxo, hydroxy, lower alkyl, aryl or heterocyclic group; and Ra is a saturated or unsaturated lower-medium aliphatic hydrocarbon residue, which is unsubstituted or substituted by halogen, oxo, lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic group or hetrocyclic-oxy group; or a cyclo(lower)alkyl; cyclo(lower)alkyloxy; an aryl; an aryloxy; a heterocyclic group; or a heterocyclic-oxy group.