Patent ID: 7988963
Filing Date: 2011-08-02
Classification: A61K,A61P,C12N

Abstract:
1. A method of inducing a cytotoxic immune response against a tumor cell in a tumor bearing patient comprising: preparing immature monocyte-derived dendritic cells from a tumor-bearing patient; co-incubating said immature dendritic cells with one or more apoptotic allogeneic tumor cell lines to obtain antigen-loaded dendritic cells; co-culturing the antigen-loaded dendritic cells with total peripheral blood mononuclear cells isolated from said tumor bearing patient, wherein T cells are neither isolated nor enriched from the peripheral blood mononuclear cells prior to the co-culturing; wherein the co-culturing results in cytotoxic T cells against the allogeneic tumor cell line(s); and administering said cytotoxic T cells to the tumor-bearing patient.