Patent ID: 6486318
Filing Date: 2002-11-26
Classification: A23L,A61K,C07D

Abstract:
A single pot process for the preparation of zinc and/or chromium picolinates useful as dietary supplements from alpha picoline, said process comprising the steps of:(a) hydrosulfonation of alpha picoline with sulfuric acid at a temperature of about 35-100Â° C. to form a reaction mixture; (b) further heating the reaction mixture thus obtained to a temperature of about 150Â°-210Â° C.; (c) oxidizing the reaction mixture of step (b) with an oxidizing agent to obtain alpha picolinic acid sulfate at a temperature of about 50-90Â° C. to form a solution; (d) maintaining the pH of the solution of step (c) at a pH of about 3 to 5 as an acidic solution; (e) treating the acidic solution of step (d) with a water soluble zinc and/or chromium salt to produce a solid metal picolinate in said water; and (f) filtering the resulting solid metal picolinate to remove such from said water and to thereby obtain the corresponding metal picolinates of high purity.