Patent ID: 6323236
Filing Date: 2001-11-27
Classification: A61K,A61P

Abstract:
A method for treating an Impulse Control Disorder comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I: ##STR4##whereinX is CH.sub.2 or oxygen;R.sub.1 is hydrogen or alkyl; andR.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl and, when X is CH.sub.2, R.sub.4 and R.sub.5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R.sub.2 and R.sub.3 and/or R.sub.4 and R.sub.5 together may be a methylenedioxy group of the follow formula (II): ##STR5##whereinR.sub.6 and R.sub.7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring;wherein the Impulse Control Disorder is selected from the group consisting of intermittent explosive disorder (ED), kleptomania, pathological gambling, pyromania, trichotillomania, compulsive buying or shopping, repetitive self-mutilation, nonparaphilic sexual addictions, severe nail biting, compulsive skin picking, personality disorders with impulsive features, attention deficit/hyperactivity disorder, Binge Eating Disorder, bulimia nervosa, anorexia nervosa with binge eating and substance use disorders.