Patent ID: 6432974
Filing Date: 2002-08-13
Classification: A61P,C07D

Abstract:
A compound of Formula 1 wherein:R1 is hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, heterocycloalkyl of 3 to 8 members, alkylcycloalkyl of 4 to 9 carbon atoms, alkylheterocycloalkyl of 4 to 9 members or (CH2)mAr or (CH2)mHet; R2 is hydrogen, alkyl of 1 to 8 carbon atoms, (CH2)nAr or (CH2)nHet; R3 is hydrogen, alkyl of 1 to 8 carbon atoms, alkylcycloalkyl of 4 to 9 carbon atoms, alkylheterocycloalkyl of 4 to 9 members, (CH2)nAr or (CH2)nHet; R4 is hydrogen or alkyl of 1 to 8 carbon atoms; R is hydrogen or alkyl of 1 to 4 carbon atoms; X is [(CH&boxH;CH)R]n, (CH2)n, or [(Câ‰¡C)R]n, CHR(CH2)n, CR2(CH2)n; a dashed line represents an optional double bond; m is an integer selected from 1 or 2; and n is an integer selected from 0, 1 or 2, or pharmaceutically acceptable salts thereof.