Patent ID: 7244745
Filing Date: 2007-07-17
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: wherein A is R R R Ar is an aryl group containing 6 to 14 carbon atoms which is unsubstituted or substituted one or more times by alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 8 carbon atoms, halogen, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, amino, cyano, hydroxyl, nitro, halogenated alkyl having 1 to 8 carbon atoms, halogenated alkoxy having 1 to 8 carbon atoms, hydroxyalkyl having 1 to 8 carbon atoms, hydroxyalkoxy having 2 to 8 carbon atoms, alkenyloxy having 3 to 8 carbon atoms, alkylthio having 1 to 8 carbon atoms, alkylsulphinyl having 1 to 8 carbon atoms, alkylsulphonyl having 1 to 8 carbon atoms, monoalkylamino having 1 to 8 carbon atoms, cycloalkylamino wherein the cycloalkyl group has 3 to 10 carbon atoms and is optionally substituted one or more times by C Het is a heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 14 ring atoms in which at least 1 ring atom is a N, O or S atom, which is substituted one or more times by halogen, aryl having 6 to 14 carbon atoms, or combinations thereof, wherein the aryl group is optionally substituted, e.g., alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 8 C atoms, cyano, trifluoromethyl, nitro, amino, monoalkylamino having 1 to 8 C atoms, dialkylamino wherein each alkyl group has 1 to 8 C atoms, or combinations thereof; or a pharmaceutically acceptable salt thereof; with the proviso that said compound is not: 3-(5,6-Dihydro-4H-[2,3′]-bipyridinyl-3-ylidenemethyl)- 9-methyl-9methyl-9H-carbazole; 3-(Thiophen-2-ylmethylene)-3,4,5,6-tetrahydro[2,3′]bipyridinyl; 3-(5-Bromothiophen-2-ylmethylene)-3,4,5,6-tetrahydro[2,3′]bipyridinyl; 3-(5-Methylthiophen-2-ylmethylene)-3,4,5,6-tetrahydro[2,3′]bipyridinyl; 3-(4-Bromothiophen-2-ylmethylene)-3,4,5,6-tetrahydro[2,3 ′]bipyridinyl; (Thiophen-3-ylmethylene)-3,4,5,6-tetrahydro[2,3′]bipyridinyl; or a pharmaceutically acceptable salt thereof.