Patent ID: 8257941
Filing Date: 2012-09-04
Classification: A61P,C12N

Abstract:
1. A method for identifying an agent that corrects a phenotype associated with a health condition or a predisposition for the health condition, comprising: (i) contacting a first population of isolated cells differentiated from a human induced pluripotent stem cell line, wherein said cells exhibit a phenotype associated with the health condition or predisposition for the health condition, with a candidate agent; (ii) contacting a second population of isolated cells differentiated from the human induced pluripotent stem cell line, wherein said cells exhibit a phenotype associated with the health condition or predisposition for the health condition, with a negative control agent; (iii) assaying a phenotype in the first population and second population after the contacting steps; and (iv) identifying the candidate agent as correcting the phenotype if the assayed phenotype of the first population after the contacting step is closer to a normal phenotype than the phenotype of the second population after the contacting step;