Patent ID: 6710055
Filing Date: 2004-03-23
Classification: C07D

Abstract:
A compound of the formula I:Raâ€”Aâ€”Hetâ€”Bâ€”Arâ€”Eâ€ƒâ€ƒ(I) wherein:A is a carbonyl or sulfonyl group linked to the pyridino moiety of the group Het; B is an ethylene group, wherein a methylene group linked to the group Ar, is optionally replaced by an oxygen or sulfur atom or by an â€”NR1â€” group, wherein R1 is a hydrogen atom or a methyl group; E is an RbNHâ€”C(&boxH;NH)â€” group, wherein Rb is a hydrogen atom or a hydroxy, C1-9-alkoxycarbonyl, cyclohexyloxycarbonyl, benzyloxycarbonyl, benzoyl, p-C1-3-alkylbenzoyl or nicotinoyl group, wherein the ethoxy moiety in the 2-position of the abovementioned C1-9-alkoxycarbonyl group is unsubstituted or additionally substituted by a C1-3-alkylsulfonyl or 2-(C1-3-alkoxy)-ethyl group, Ar is a 1,4-phenylene group optionally substituted by a chlorine atom or by a methyl, ethyl, or methoxy group, or is a 2,5-thienylene group; Het is a 3-methyl-2,6-imidazo[4,5-b]pyridinylene group; and Ra is a C1-6-alkyl group, a C3-7-cycloalkyl group optionally substituted by a C1-3-alkyl group, wherein the C1-3-alkyl group may additionally be substituted by a carboxyl, C1-6-alkoxycarbonyl, cyclohexyloxcarbonyl, or phenyl-C1-3-alkoxycarbonyl group, or Ra is a R2NR3â€” group, wherein R2 is a C1-4-alkyl group optionally substituted by a carboxy, C1-6-alkyloxycarbonyl, benzyloxycarbonyl, methylsulfonylaminocarbonyl, or 1H-tetrazol-5-yl group, a C2-4-alkyl group substituted at a carbon which is other than the one at the &agr;-position relative to the adjacent nitrogen atom, by a hydroxy, benzyloxy, carboxy-C1-3-alkyl-amino, C1-3-alkoxycarbonyl-C1-3-alkylamino, Nâ€”(C1-3-alkyl)-carboxy-C1-3-alkylamino, or Nâ€”(C1-3-alkyl)-C1-3-alkoxycarbonyl-C1-3-alkylamino group, and R3 is a propargyl group, wherein the unsaturated moiety is not linked directly to the nitrogen atom of the R2NR3â€” group, is a phenyl group optionally substituted by a fluorine or chlorine atom, or by a methyl or methoxy group, or is a pyridinyl group, and or a tautomer or salt thereof.