Patent ID: 6030956
Filing Date: 2000-02-29
Classification: A61K,Y10T

Abstract:
A vector combination for use in cancer treatment, comprising(a) a wildtype (wt) p53 expression vector containing (i) a promoter active in tumor cells, (ii) a human p53 gene under the control of said promoter, said gene being mutagenized at its Pax5-binding site to inhibit or prevent gene suppression by Pax5 protein, and (iii) a human origin of replication able to sustain long term expression of the p53 gene in tumor cells; and(b) a Pax5 expression vector containing (i) a promoter active in tumor cells, (ii) a human Pax5 gene under the control of said promoter, and (iii) a human origin of replication able to sustain long term expression of the Pax5 gene in tumor cells.