Patent ID: 8716304
Filing Date: 2014-05-06
Classification: A61P,C07D

Abstract:
1. A method for preparation of a compound represented by the following formula 1, which method comprises the following steps: preparing a compound represented by the following formula 5 by hydrogenating a compound represented by the following formula 6 in the presence of a palladium catalyst (step 1); preparing a compound represented by the following formula 7 by reacting the compound of formula 5 with NaBH preparing a compound represented by the following formula 4 by reacting the compound of formula 7 with trimethyl aluminum (step 3); preparing a compound represented by the following formula 3 by reacting the compound of formula 4 with thionyl chloride to prepare a cyclic sulfite compound, which is then oxidized by means of RuCl preparing a compound represented by the following formula 8 by reacting the compound of formula 3 with N preparing a compound represented by the following formula 9 by reacting the compound of formula 8 with phenyl chlorothionoformate to prepare a thiocarbonate compound, which is then reacted with n-Bu preparing a compound represented by the following formula 10 by reacting the compound of formula 9. HF (step 7); preparing a compound represented by the following formula 11 by reacting the compound of formula 10 with chlorosulfonamide (step 8); and preparing a compound represented by the following formula 1 by reacting the compound of formula 11 with TFA (step 9):