Patent ID: 6040451
Filing Date: 2000-03-21
Classification: A61P,C07D

Abstract:
A compound having the structure: wherein each of R.sub.1, R.sub.2 and R.sub.3 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl;wherein each of R.sub.4, R.sub.5 and R.sub.6 is independently --H, --F, --Cl, --Br, --I, --OH, --OR.sub.7, --OCOR.sub.7, --SR.sub.7, --N(R.sub.7).sub.2, --CN, --CO.sub.2 R.sub.7, --CON(R.sub.7).sub. 2, or --COR.sub.7 ; straight chained or branched C.sub.1 -C.sub.7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; C.sub.4 -C.sub.7 heterocycloalkyl or heteroaryl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each R.sub.7 is independently --H; --N(R.sub.10).sub.2, --NR.sub.10 COR.sub.10, --(CH.sub.2).sub.n OR.sub.10, --SO.sub.n R.sub.10, --SO.sub.n N(R.sub.10).sub.2, --(CH.sub.2).sub.n N(R.sub.10).sub.2, or --(CH.sub.2).sub.n NR.sub.10 COR.sub.10 ; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sup.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each n is independently an integer from 1 to 4;wherein each R.sub.8 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON (R.sub.10).sub.2 ;wherein R.sub.9 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; C.sub.3 -C.sub.7 cycloalkyl or cycloalkenyl; C.sub.4 -C.sub.7 heterocycloalkyl or heteroaryl; phenyl, substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl wherein the substituted phenyl or phenyl substituted C.sub.1 -C.sub.4 alkyl is substituted with --H, --F, --Cl, --Br, --I, --NO.sub.2, --CN, straight chained or branched C.sub.1 -C.sub.7 alkyl, straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl, --NR.sub.10, --OR.sub.10, --COR.sub.10, --CO.sub.2 R.sub.10, or --CON(R.sub.10).sub.2 ;wherein each R.sub.10 is independently --H; straight chained or branched C.sub.1 -C.sub.7 alkyl; straight chained or branched C.sub.2 -C.sub.7 alkenyl or alkynyl; andwherein X is independently CH.sub.2, O, NH or S; ora pharmaceutically acceptable salt thereof.