Patent ID: 6015569
Filing Date: 2000-01-18
Classification: A61K,A61P,A61Q,Y10S

Abstract:
A polycyclic aromatic compound having the structural formula (I): ##STR8## in which R.sub.1 is a --CH.sub.3 radical, a --CH.sub.2 --O--R.sub.3 radical, a --CH.sub.2 --O--CO--R.sub.4 radical, an --O--R.sub.5 radical, an --O--(--CH.sub.2 --)--.sub.m --(--CO--)--.sub.n --R.sub.6 radical, a --CO--R.sub.7 radical, a --CO--O--R.sub.8 radical or an --S(O).sub.p --R.sub.9 radical, wherein m, n, p and the radicals R.sub.3 to R.sub.9 are as defined below; R.sub.2 is a hydrogen atom or a halogen atom, a lower alkyl radical, an --NO.sub.2 radical, an --O--COR.sub.4 radical, an --OR.sub.9 radical or a radical: ##STR9## wherein the radicals R.sub.4, R.sub.9 and R.sub.10 are as defined below; Ar is a radical selected from among those of the following formulae (b) and (e): ##STR10## X is --O--, --S(O).sub.t -- or an --NR.sub.9 -- radical wherein t is as defined below; Y and Z are each --O--, --S(O).sub.t -- or a radical --CR.sub.11 R.sub.12, wherein the radicals R.sub.11 and R.sub.12 are as defined below; m is an integer equal to 1, 2 or 3; n is an integer equal to 0 or 1; p is an integer equal to 0, 1, 2 or 3; t is an integer equal to 0, 1 or 2; R.sub.3 is a hydrogen atom or a lower alkyl radical; R.sub.4 is a lower alkyl radical; R.sub.5 is a hydrogen atom or a lower alkyl radical; R.sub.6 is a lower alkyl radical or a heterocycle; R.sub.7 is a hydrogen atom, a lower alkyl radical or a radical: ##STR11## in which R' and R"", which may be identical or different, are each a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyallyl radical, an optionally substituted aryl radical, or an amino acid or peptide or sugar residue, with the proviso that R' and R"" may together form, with the nitrogen atom from which they depend, a nitrogen-containing heterocycle; R.sub.8 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, an alkenyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical or a sugar residue or an amino acid or peptide residue; R.sub.9 is a hydrogen atom or a lower alkyl radical; R.sub.10 is a hydrogen atom or a lower alkyl radical; R.sub.11 is a hydrogen atom or a lower alkyl radical; R.sub.12 is a hydrogen atom or a lower alkyl radical; with the proviso that Y and Z cannot at the same time each be an oxygen atom or an --S(O).sub.t -- radical; and with the further proviso that (i) if R.sub.1 is --O--R.sub.5, then R.sub.5 is not a lower alkyl radical; (ii) if R.sub.1 is --O--(CH.sub.2).sub.m (CO).sub.n --R.sub.6, then m is not 2 or 3; (iii) if R.sub.1 is --CO--R.sub.7, then R.sub.7 is not a lower alkyl radical; and (iv) if R.sub.1 is --S(O).sub.p --R.sub.9, then R.sub.9 is not a lower alkyl radical; or a pharmaceutically/cosmetically acceptable salt or optical or geometric isomer thereof.