Patent ID: 6630463
Filing Date: 2003-10-07
Classification: A61P,C07D

Abstract:
A heterocycle-containing carboxylic acid derivative or a physiologically acceptable salt thereof represented by the following formula (I): where A is a group represented by the following formula: in which J represents a nitrogen atom which may have a substituent; R1, R2 and R3 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, a lower alkoxy group which may have a substituent, a cycloalkyloxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an aryloxy group which my have a substituent, a heteroaryloxy group which may have a substituent, a cycloalkylalkyl group which may have a substituent, an arylalkyl group which may have a substituent, a heteroarylalkyl group which may have a substituent, a cycloalkylalkyloxy group which may have a substituent, an arylalkyloxy group which may have a substituent, a heteroarylalkyloxy group which may have a substituent, an alkenyl group which may have a substituent or an alkynyl group which may have a substituent, or R1 and R2 are coupled together to form a cycloalkylene group which may have a substituent, a carbon group forming said cycloalkylene group may be substituted by a sulfur atom, an oxygen atom, a sulfinyl group, a sulfonyl group or >NR4, R4 representing a hydrogen atom or a lower alkyl group, and n2 stands for an integer of 1 to 3; B is a heteroarylene group which may have a substituent, an arylene group which may have a substituent, or a group represented by the following formula: wherein R5 represents a hydrogen atom or a lower alkyl group; m2 stands for 0 to 2; R8 to R15 are the same or different and each independently represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom, a sulfur atom or >NR4, R4 having the same meaning as defined above; D is an arylene group which may have a substituent, a heteroarylene group which may have a substituent or â€”CR6&boxH;CR7â€”; in which R6 and R7 are the same or different from each other and represent a hydrogen atom, a lower alkyl or a halogen atom; n1 stands for 0 or 1; M is a hydroxyl group, a lower alkoxy group or a group represented by the following formula: â€”NR16R17 in which R16 and R17 are the same or different and each independently represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a hydroxyalkyl group, an aryl group or a heteroaryl group or R16 and R17 are coupled together with the adjacent nitrogen atom to form an oxygen- or sulfur containing ring; and represents a single bond or double bond; or a physiologically acceptable salt thereof.