Patent ID: 6503509
Filing Date: 2003-01-07
Classification: A61K,A61P,C07K,G01N,Y10S

Abstract:
A method to desensitize a B cell antigen receptor, said method comprising: contacting a B cell antigen receptor with an antibody, wherein said B cell antigen receptor has a transducer component consisting of an Ig&agr;-Ig&bgr; dimer, and a membrane Ig (mIg) component, wherein said antibody binds to the extracellular domain of said transducer component;wherein contact with said antibody: (1) causes a dissociation of said mIg component from said transducer component when said components are associated with each other prior to contact with said antibody; or (2) inhibits association of said mIg component with said transducer component when said components are dissociated from each other prior to contact with said antibody; and wherein said B cell antigen receptor remains competent to bind its antigen, and fails, or has a reduced ability, to transduce signals.