Patent ID: 6350754
Filing Date: 2002-02-26
Classification: C07D

Abstract:
A compound having the following chemical structure: wherein, A and B are independently selected from the group consisting of carbon, nitrogen, oxygen and sulfur wherein, at least one of A or B must be nitrogen, oxygen or sulfur; when either A or B is oxygen or sulfur, the other must be either carbon or nitrogen and when the other is nitrogen, R7 does not exist; when A and B are both nitrogen, R7 is bonded to whichever of A or B is not participating in one of the heteroaryl ring double bonds; Z is selected from the group consisting of oxygen, sulfur and NR12 wherein, R12 is selected from the group consisting hydrogen, alkyl, cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, carbonyl, C-carboxyl, O-carboxyl, C-amido, guanyl, sulfonyl and trihalomethanesulfonyl; R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, indole, pyrimidine, hydroxy, alkoxy, trihalomethanecarbonyl, sulfonyl, trihalomethanesulfonyl, C-carboxyl, O-carboxyl, C-amido, and guanyl; n is 0 or 1; R2 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and halogen; R3, R3â€², R4, R4â€², R5, R5â€², R6 and R6â€² are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, indole, pyrimidine, alkoxy, aryloxy, thioalkoxy, thioaryloxy, heteroaryloxy, wherein the heteroaryl moiety of said heteroaryloxy is indole or pyrimidine, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethanelsulfonyl, carbonyl, C-carboxyl, O-carboxyl, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, phosphonyl, N-thiocarbamyl, guanyl, guanidino, ureido, amino trihalomethane sulfonamido, and â€”NR13R14; wherein, R13 and R14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a five-or six-member heteroalicyclic ring containing at least one nitrogen; when any of R3, R4, R5 and R6 are hydrogen, R3â€², R4â€², R5â€² and R6â€², respectively, in addition to being independently selected from the above group, may be independently selected from the group consisting of hydroxy and â€”SH; combined, R3 and R3â€², R4 and R4â€², R5 and R5â€² and R6 and R6â€² may be independently selected from the group consisting of keto, five-member spirocycloalkyl, or six-member spirocycloalkyl; R7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, trihalomethanecarbonyl, alkenyl, alkynyl, aryl, indole, pyrimidine, C-carboxyl, O-carboxyl, C-amido, halo, cyano, hydroxy, alkoxy, sulfonyl and trihalomethanesulfonyl; R8, R9, R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, alkenyl, alkynyl, cycoalkyl, aryl, indole, pyrimidine, hydroxy, alkoxy, cycloalkoxy, aryloxy, heteraryloxy, wherein the heteroaryl moiety of said heteroaryloxy is indole or pyrimidine, â€”SH, thioalkoxy, â€”S-alkyl, â€”S-aryl, â€”S-heteroaryl, wherein the heteroaryl moiety of said â€”S-heteroaryl is indole or pyrimidine, halo, nitro, cyano, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, silyl, phosphonyl, C-carboxyl O-carboxyl, N-amido, C-amido, sulfmyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethanesulfonyl, guanyl, guanidino, trihalomethanesulfonamido, amino, and â€”NR13R14; wherein, R13 and R14 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, C-carboxy, sulfonyl, trihalomethanesulfonyl and, combined, a five-or six-member heteroalicvlic ring containing at least one nitrogen; and physiologically acceptable salts and prodrugs thereof.