Patent ID: 6251858
Filing Date: 2001-06-26
Classification: A61K,A61P,C07H

Abstract:
Compounds of the general formula (I) ##STR71##in which:a=0 or 1,j=0 or 1,b=0 or 1,p=2 to 4,provided thata=b=0, when j=1, which leads to the presence of a cyclic molecule,or a=b=1, when j=0 which implies the absence of the (CH.sub.2).sub.p group,D represents a residue of an organic acid of the formula ECO.sub.2 H, wherein E is H or an alkyl chain of 1 to 10 carbon atoms,Z representsB, B being H, an alkyl of 1 to 10 carbon atoms or a side chain of an .alpha. amino acid, orB'--P', B' being an alkylene chain of 1 to 10 carbon atoms or a side chain of an .alpha. amino acid, the said chains containing a group derived from a functional group able to be activated, P' having the significations indicated hereafter,X represents: ##STR72##m being an integer from 0 to 10, k=0 or 1Q representing OH, OCH.sub.3, OCH.sub.2 --C.sub.6 H.sub.5, O--C.sub.6 H.sub.5, O--C.sub.6 F.sub.5, O-pC.sub.6 H.sub.4 --NO.sub.2, or ##STR73##R representing a group possessing an alcohol, phenol, thiol, or amine function,A.sub.i representing an organic radical,P, P', and P"" are identical or different and represent:a matrix support for affinity chromatography;a bead of gold, or latex;a protein;a lipid;oligonucleotides; ora polymer;P, P' and P"" possessing at least one chemical function allowing a condensation reaction by reaction with an oligopeptide,wherein the oligosidyl moiety of formula (I) comprises a terminal cyclic hemiacetal residue in which the hemiacetalic hydroxy is replaced by the N of formula (I), thereby to render said hemiacetal non-reducing.