Patent ID: 7915241
Filing Date: 2011-03-29
Classification: C07C,C07F

Abstract:
1. A process for the preparation of compounds of Formula 1 having a (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR 1 group, where R 1 , R 2 and R 3 may be the same or different and represent groups suitable for hydroxyl protection, and R 4 is a C 1-6 alkyl chain or a C 3-6 cycloalkyl group, optionally substituted with C 1-3 alkyl groups, comprising the steps of: (a) reacting a sulfone of Formula 5, possessing a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxyl group or an OR with an aldehyde of Formula 6, having an (R) or an (S) configuration at the carbon atom directly attached to the carbonyl group, wherein R 3 is a hydrogen atom or a group suitable for hydroxyl protection and R 4 is a C1-6 alkyl chain or a C3-6 cycloalkyl group, optionally substituted with C1-3 alkyl groups, in the presence of a strong base, in a solvent selected from the group consisting of hydrocarbons and ethers, and (b) optionally, in case the product obtained in step (a) represented by formula 1 in which R (c) removing the protective groups, R