Patent ID: 6635674
Filing Date: 2003-10-21
Classification: A61K

Abstract:
An anti-inflammatory analgesic pharmaceutical topical composition comprising(a) an anti-inflammatory and analgesic effective amount of a non-steroidal anti-inflammatory and analgesic agent; (b) a skin penetration enhancer selected from the group consisting of oleic acid, oleyl alcohol and mixtures thereof, the enhancer being present in an amount sufficient to enhance skin penetration of the non-steroidal anti-inflammatory and analgesic agent, as compared to a like composition that does not contain the enhancer; and (c) a pharmaceutically acceptable vehicle for the non-steroidal anti-inflammatory and analgesic agent and the skin penetration enhancer consisting of 15 to 70 weight %, based on the total weight of the composition, of a monohydric saturated aliphatic alcohol containing 1 to 4 carbon atoms; 0.1 to 30 weight %, based on the total weight of the composition, of a polyhydric alcohol selected from the group consisting of saturated aliphatic glycols containing 2 to 4 carbon atoms and glycerol; and 10 to 60 weight %, based on the total weight of the composition, of water.