Patent ID: 6461831
Filing Date: 2002-10-08
Classification: C12N,G01N,Y10S

Abstract:
A method for the diagnosis of Alzheimer's disease (AD) in a patient, comprising the steps of:(1) providing a sample of an appropriate body fluid from said patient; (2) detecting the presence in said sample of an acetylcholinesterase (AChE) having an altered glycosylation pattern such that it has a relatively lesser affinity for Concanavalin A (Con A) and a relatively greater affinity for wheat germ agglutinin (WGA) than an AChE with an unaltered glycosylation pattern; (3) correlating the presence of said AChE having a glycosylation pattern such that it has a relatively lesser affinity for Con A and a relatively greater affinity for WGA than an AChE with an unaltered glycosylation pattern, with AD in said patient.