Patent ID: 6514985
Filing Date: 2003-02-04
Classification: A61K,A61P,C07D

Abstract:
A compound of the formula II: whereinB is â€”NRâ€”C(R)2â€”C(R)2â€”C(R)2â€”; â€”C(R)2â€”NRâ€”C(R)2â€”C(R)2â€”; â€”C(R)2â€”C(R)2â€”NRâ€”C(R)2â€” or â€”C(R)2â€”C(R)2â€”C(R)2â€”NRâ€”; R1 is selected from the group consisting of: -hydrogen; â€”C1-20 alkyl or C2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisting of: -aryl; -heteroaryl; -heterocyclyl; â€”Oâ€”C1-20 alkyl, â€”Oâ€”(C1-20 alkyl)0-1-aryl; â€”Oâ€”(C1-20 alkyl)0-1-heteroaryl; â€”Oâ€”(C1-20 alkyl)0-1-heterocyclyl; â€”C1-20 alkoxycarbonyl; â€”S(O)0-2â€”C1-20 alkyl; â€”S(O)0-2â€”(C1-20 alkyl)0-1-aryl; â€”S(O)0-2â€”(C1-20 alkyl)0-1-heteroaryl; â€”S(O)0-2â€”(C1-20 alkyl)0-1heterocyclyl; â€”N(R3)2; â€”N3; oxo; -halogen; â€”NO2; â€”OH; and â€”SH; and â€”C1-20 alkyl-NR3â€”Qâ€”Xâ€”R4 or â€”C2-20 alkenyl-NR3â€”COâ€”Xâ€”R4 wherein Q is â€”COâ€” or â€”SO2â€”; X is a bond, â€”Oâ€” or â€”NR3â€” and R4 is aryl; heteroaryl; heterocyclyl; or â€”C1-20 alkyl or C2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisting of: -aryl; -heteroaryl; -heterocyclyl; â€”Oâ€”C1-20 alkyl, â€”Oâ€”(C1-20 alkyl)0-1-aryl; â€”Oâ€”(C1-20 alkyl)0-1-heteroaryl; â€”Oâ€”(C1-20 alkyl)0-1-heterocyclyl; â€”C1-20 alkoxycarbonyl; â€”S(O)0-2â€”C1-20 alkyl; â€”S(O)0-2â€”(C1-20 alkyl)0-1-aryl; â€”S(O)0-2â€”(C1-20 alkyl)0-1-heteroaryl; â€”S(O)0-2â€”(C1-20 alkyl)0-1-heterocyclyl; â€”N(R3)2; â€”NR3â€”COâ€”Oâ€”C1-20 alkyl; â€”N3; oxo; -halogen; â€”NO2; â€”OH; and â€”SH; or R4 is wherein Y is â€”Nâ€” or â€”CRâ€”; R2 is selected from the group consisting of: -hydrogen; â€”C1-10 alkyl; â€”C1-10 alkenyl; -aryl; â€”C1-10 alkylâ€”Oâ€”C1-10-alkyl; â€”C1-10 alkylâ€”Oâ€”C2-10 alkenyl; and â€”C1-10 alkyl or C2-10 alkenyl substituted by one or more substituents selected from the group consisting of: â€”OH; -halogen; â€”N(R3)2; â€”COâ€”N(R3)2; â€”COâ€”C1-10 alkyl; â€”N3; -aryl; -heteroaryl; -heterocyclyl; â€”CO-aryl; and â€”CO-heteroaryl; each R3 is independently selected from the group consisting of hydrogen and C1-10 alkyl; and each R is independently selected from the group consisting of hydrogen, C1-10 alkyl, C1-10 alkoxy, halogen and trifluoromethyl, or a pharmaceutically acceptable salt thereof.