Patent ID: 6627619
Filing Date: 2003-09-30
Classification: A01K,A61K,C07K,C12N,C12Y

Abstract:
A method for inhibiting expression of human telomerase reverse transcriptase (hTRT) protein in a cell, comprising contacting the cell with an antisense oligonucleotide that hybridizes to a target DNA having the nucleotide sequence of SEQ ID NO:1 at 5Â° C. to 25Â° C. below Tm in aqueous solution at 1 M NaCl;wherein Tm is the melting temperature of a complementary oligonucleotide hybridized to the target DNA in aqueous solution at 1 M NaCl, wherein the complementary oligonucleotide is exactly complementary to SEQ ID NO:1 and the same length as the antisense oligonucleotide; and wherein hybridization of the antisense oligonucleotide to an mRNA encoding hTRT (SEQ ID NO:1) inhibits expression of the mRNA.