Patent ID: 8044207
Filing Date: 2011-10-25
Classification: A61P,C07D

Abstract:
1. A process for preparing a 2-halo-6-(piperidin-4-carbonyl)pyridine compound of formula III: where X is bromo or chloro; R R n is an integer from 1 to 6 inclusively; comprising 1) reacting a 2,6-dihalopyridine selected from 2,6-dibromopyridine and 2,6-dichloropyridine, with n-butyl lithium to form 2-halo-6-lithium-pyridine, and then 2) reacting the 2-halo-6-lithium-pyridine with a substituted aminocarbonylpiperidine compound of formula IV: wherein R 9 and R 10 are each methyl, or R 9 and R 10 , together with the nitrogen to which they are attached, combine to form azetidinyl, pyrrolidinyl, or piperidinyl.