Patent ID: 6297264
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound of formula (1) ##STR21##wherein.dbd.W-- is .dbd.N--;L is --XR, --C(R.sup.11).dbd.C(R.sup.1)(R.sup.2) or --(CHR.sup.11).sub.n CH(R.sup.1)(R.sup.2), wherein n is zero or the integer 1;Z is (1) a group --C(R.sup.3)(R.sup.4)C(R.sup.5)(R.sup.6)(R.sup.7) or --C(R.sup.4).dbd.C(R.sup.5)(R.sup.6);X is --O--, --S(O).sub.m --, or --N(R.sup.b)--, wherein m is zero or an integer 1 or 2;R is an optionally substituted alkyl or alkenyl group;R.sup.b is hydrogen or an optionally substituted alkyl group;R.sup.1 and R.sup.2 are independently hydrogen, fluorine, --CN, --NO.sub.2, or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkylthio, --CO.sub.2 R.sup.8, --CONR.sup.9 R.sup.10 or --CSNR.sup.9 R.sup.10 group;R.sup.3 is hydrogen, fluorine, or an optionally substituted straight or branched alkyl group;R.sup.4 is --X.sup.a L.sup.1 R.sup.12, --Alk.sup.1 R.sup.12, --CH.sub.2 L.sup.1 R.sup.12a, --X.sup.a R.sup.12a or --C(X.sup.b)R.sup.12a, wherein:X.sup.a is --O--, --S(O).sub.m -- or --N(R.sup.b)--;X.sup.b is --O-- or --S--;L.sup.1 is --(Alk.sup.2).sub.r (X.sup.a).sub.s (Alk.sup.3).sub.t -- where r, s and t are zero or the integer 1;R.sup.12 and R.sup.12a are independently an optionally substituted cycloaliphatic group or an optionally substituted monocyclic or bicyclic aryl group;Alk.sup.1 is an optionally substituted straight or branched alkenylene or alkynylene chain optionally interrupted by one or more --O-- or --S-- atoms or --N(R.sup.b)--, carbocyclic or heteroatom-containing groups; andAlk.sup.2 and Alk.sup.3 are independently an optionally substituted straight or branched alkylene, alkenylene or alkynylene chain optionally interrupted by one or more heteroatoms or carbocyclic or heteroatom-containing groups;R.sup.5 is a --(CH.sub.2).sub.p Ar group where p is zero or an integer 1, 2 or 3 and Ar is an optionally substituted six-membered heteroaryl group containing one nitrogen atom;R.sup.6 is hydrogen, fluorine, or an optionally substituted alkyl group;R.sup.7 is hydrogen, fluorine, an optionally substituted straight or branched alkyl group, or --OR.sup.c, where R.sup.c is hydrogen, formyl, alkoxyalkyl, alkanoyl, carboxamido, thiocarboxamido or an optionally substituted alkyl or alkenyl group;R.sup.8, R.sup.9 and R.sup.10 are independently hydrogen or an optionally substituted alkyl group; andR.sup.11 is hydrogen, fluorine or methyl; orZ is (2) a group --C(R.sup.4)C(R.sup.5)(R.sup.6)(R.sup.7), where R.sup.4 is .dbd.CH.sub.2, or --CH(L.sup.1).sub.n R.sup.12 ;with the provisos that when one of r, s and t is 0, then at least one of the other of r, s and t is 1, when s is 1, then r is 1, and when L.sup.1 is adjacent to X.sup.a and s is 1, then r is also 1;and the salts, solvates, hydrates and N-oxides thereof.