Patent ID: 6500464
Filing Date: 2002-12-31
Classification: A61F,Y10S

Abstract:
A process for preparing a collagen construct comprising a porous, cell-permeable collagen layer, a cell-impermeable transitional collagen layer, and a cell-hospitable attachment layer comprising a collagen material which is different from the collagen material of the cell-impermeable transitional layer which comprisesa) providing a collagen suspension on a surface and placing a porous; cell-permeable collagen sponge thereon, whereby the porous, cell-permeable sponge imbibes the suspension to a desired depth into the sponge, b) drying the collagen suspension on the porous, cell-permeable sponge thereby creating on the cell-permeable collagen sponge a cell-impermeable collagen layer connected to said collagen sponge via a transition layer having an external surface, and c) applying to the external surface of the cell-impermeable layer a solution of a collagen material which is different from the collagen material of the cell-impermeable transitional layer and drying the resulting construct.