Patent ID: 6165477
Filing Date: 2000-12-26
Classification: A61K,A61P,C07K,C12N,G01N,Y02A

Abstract:
An immunogenic composition which generates protective, neutralizing antibody responses to a Flavivirus in a murine host which responses confer protection against intracerebral challenge by the homologous Flavivirus, said strain of Flavivirus selected from the group consisting of a strain of dengue, a strain of Japanese encephalitis virus (JEV), a strain of yellow fever virus (YF), and a strain of tick-borne encephalitis virus (TBE)which composition contains an adjuvant; anda portion of the envelope protein (E) of the Flavivirus strain against which said responses are sought, which portion is 80% E, wherein said 80% E represents that portion of the envelope protein that constitutes 80% of its length starting from amino acid 1 at its N-terminus and which portion has been secreted as a recombinantly produced protein from Drosophila cells.