Patent ID: 6084112
Filing Date: 2000-07-04
Classification: C07C,C07K

Abstract:
A method for preparing a compound having the formula ##STR8## said method comprising: (a) reacting a cycloalkanone compound having the formula: ##STR9## with formic acid an hydroxylamine-O-sulfonic acid to provide a lactam having the formula: ##STR10## (b) reacting said lactam with an aqueous base to form an amine salt; and (c) acylating said amine salt with a compound having the formula: ##STR11## or a Boc protected amino acid succinate ester; whereinY is carbonyl or oxycarbonyl;Z is a bond or an amino acid residue;R.sup.1 is C.sub.5 -C.sub.9 alkyl;R.sup.2 is hydrogen;R.sup.3 is tert-butyl or hydroxyphenyl;R.sup.4 is hydrogen; andX is a leaving group.