Patent ID: 8992929
Filing Date: 2015-03-31
Classification: A61K,A61P,C07K

Abstract:
1. A monoclonal antibody or antibody fragment which specifically binds to a conformational epitope of H5 hemagglutinin, wherein the conformational epitope of H5 hemagglutinin is one to which murine monoclonal antibody 4C2 as produced by hybridoma 4C2 which is deposited with the American Type Culture Collection with Accession Number PTA-11241 specifically binds, wherein the conformational epitope is comprised of amino acid 155 (Ser) and amino acid 189 (Arg) of mature H5 hemagglutinin, and wherein the complementarity determining regions of the light chain variable region (LCDRs) are within the amino acid sequence set forth in SEQ ID NO:2 and the complementarity determining regions of the heavy chain variable region (HCDRs) are within the amino acid sequence set forth in SEQ ID NO:4.