Patent ID: 6799122
Filing Date: 2004-09-28
Classification: C12Q,Y02A

Abstract:
A method for identifying polymorphic markers in a population, comprising the steps of:selecting a first and second individual from a plurality of individuals of the population; providing a reference genomic DNA microarray; hybridizing genomic DNA of each of the first and second individuals to the reference microarray; determining segments of hybridization between the genomic DNA of each of the first and second individuals and the reference microarray; calculating a hybridization intensity ratio for each hybridized and non-hybridized segment; converting each intensity ratio into a binary digit consisting of a 0 or 1 bit such that each segment of the reference microarray is represented by a 0 or 1 bit; compiling data consisting of the numerical elements to produce a bit string for each individual, each bit string having the same total number of bits and each bit having a unique position common to both strings; and analyzing the data to identify patterns of hybridization present in the population, wherein the relatedness of the bit strings is determined by comparing the value of each bit within the bit string of the first individual to the value of each bit within the bit string of the second individual.