Patent ID: 7345022
Filing Date: 2008-03-18
Classification: A61K,C07K

Abstract:
1. A compound for inhibiting the toxicity of an amyloid protein or amyloid peptide, wherein the amyloid protein or amyloid peptide comprises an aggregation-inducing sequence of at least four modified or unmodified amino acids; said compound comprising a peptidyl sequence selected from the group consisting of: wherein: (a) X (b) Y (c) (S) (d) either or both ends of said peptidyl sequence optionally comprise additional functionality that does not adversely affect the compound's ability to inhibit the toxicity of an amyloid protein or amyloid peptide, as compared to an otherwise identical compound lacking such additional functionality; (e) the number of amino acids in the aggregation sequence of the amyloid protein or amyloid peptide may be the same as, or different from, the number of natural or synthetic amino acids in said peptidyl sequence; and (f) said compound is neither Lys-Dibg-Val-Dbzg-Phe-Dpg-(Lys)