Patent ID: 6043269
Filing Date: 2000-03-28
Classification: C07D

Abstract:
A compound of the formula: ##STR40## wherein: R.sup.1 is SO.sub.2 NR.sub.2.sub.4, SO.sub.2 NHR.sup.4 or benzyl;R.sup.2 and R.sup.3 are arranged in cis-configuration;R.sup.2 is phenyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 alkoxy and phenyl;R.sup.3 is phenyl substituted with --X--(CH.sub.2).sub.n --Y, wherein:X is a valency bond, O or S,n is an integer in the range of 1 to 12,Y is H, halogen, OH, OR.sup.4, NHR.sup.4, NR.sub.2.sup.4, NHCOR.sup.4, NHSO.sub.2 R.sup.4,CONHR.sup.4,CONR.sub.2.sup.4, COOH, COOR.sup.4, SO.sub.2 R.sup.4, SOR.sup.4, SONHR.sup.4, SONR.sub.2.sup.4, a pyrrolidinyl ring, optionally being substituted with 1 to 3 substituents independently selected from the group consisting of H, OH, halogen, nitro, cyano, SH, SR.sup.4, trihalo-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl and C.sub.1 -C.sub.6 -alkoxy; andR.sup.4 is C.sub.1 -C.sub.6 -alkyl;and optical and geometrical isomers, pharmaceutically acceptable esters, ethers and salts thereof.