Patent ID: 6413542
Filing Date: 2002-07-02
Classification: A01N,A61K

Abstract:
A process for the control or elimination of external parasites from cattle and sheep, comprising topically applying, at least monthly, to a localized region on the back of the cattle or sheep, and diffusion therefrom over the animal's body and/or in the sebaceous glands of the animal and thereby obtain said control or elimination, a parasitically effective amount of a direct pour-on skin solution comprising from 0.05 to 25% weight/volume, relative to the total solution, of a compound of formula (I): wherein:R1 is CN; R2 is S(O)nR3; R3 is haloalkyl; R4 represents NH2; R11 represents a halogen atom; X is Câ€”R12; R12 represents a halogen atom; R13 represents a haloalkyl; n represents an integer equal to 0, 1 or 2 wherein the compound of formula (I) is formulated in a direct pour-on skin solution comprising the compound (I), for application in a volume of 5 to 20 ml per kg of animal, and designed to release the compound (I) onto the skin and the hairs for a contact action against the parasites; and said solution contains a vehicle or diluent and optionally one or more of: a solvent, and an emollient and/or spreading agent and/or film-forming agent; wherein the vehicle or diluent is oily; wherein the organic solvent is selected from the group consisting of acetyltributyl citrate, fatty acid esters, acetone, acetonitrile, benzyl alcohol, butyl diglycol, dimethyl-acetamide, dimethylformamide, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, etyhlene glycol monoethyl ether, ethylene glycol monomethyl ether, monomethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol, 2-pyrrolidone, N-methylpyrrolidone, diethylene glycol monoethyl ether, ethylene glycol and diethyl phthalate, and combinations thereof; and wherein the emollient and/or spreading agent and/or film forming agent is selected from the group consisting of: polyvinylpyrrolidone, polyvinyl alcohols, copolymers of vinyl acetate and vinylpyrrolidone, polyethylene glycols, benzyl alcohol, mannitol, glycerol, sorbitol, polyoxyethylenated sorbitan esters, lecithin, sodium carboxymethylcellulose, silicone oils, polydiorganosiloxane oils, polydimethylsiloxane oils, anionic surfactants selected from the group consisting of alkaline stearates, sodium stearate, potassium stearate, ammonium stearate, calcium stearate, triethanolamine stearate, sodium abietate, alkyl sulphates, sodium lauryl sulphate and sodium cetyl sulphate, sodium dodecylbenzenesulphonate, sodium dioctylsulphosuccinate, fatty acids, and fatty acids derived from coconut oil, cationic surfactants selected from the group consisting of water-soluble quaternary ammonium salts of formula N+Râ€²Râ€³Râ€²â€³Râ€³â€³, Yâˆ’ in which the radicals R are optionally hydroxylated hydrocarbon radicals and Yâˆ’ is an anion of a strong acid, amine salts of the formula N+Râ€²Râ€³Râ€²â€³ in which the radicals R are optionally hydrolated hydrocarbon radicals, nonionic surfactans such as sorbitan esters, which are optionally polyoxyethylenated, polyoxyethylenated alkyl ethers, polyoxypropylated fatty alcohols, polyoxyethylenated derivates of castor oil, polyglycerol esters, polyoxyethylenated fatty alcohols, polyoxyethylenated fatty acids, and copolymers of ethylene oxide and propylene oxide, amphoteric surfactants including substituted lauryl compounds of betaine, and combinations thereof.