Patent ID: 6546340
Filing Date: 2003-04-08
Classification: C12Q,G16B,Y10S

Abstract:
A computer program product that calls an unknown base in a sample nucleic acid sequence, comprising:computer code that defines a set of potential base calls, said base calls including at least one of A, C, G, T(U), deletion, insertion, and a plurality of ambiguous calls; computer code that inputs a plurality of measurements for hybridization between a plurality of probes and said sample nucleic acid sequence or nucleic acid derived from said sample nucleic acid sequence; computer code that determines a plurality of probabilities, each of said probabilities reflecting the likelihood that one of the potential base calls is correct, said probabilities being calculated according to a distribution model, said hybridization measurements and sequences of said plurality of probes; computer code that calls the unknown base according to the probabilities of said potential base calls; and a computer readable medium that stores the computer codes.