Patent ID: 9212348
Filing Date: 2015-12-15
Classification: A61K,A61P,C07D,C12N

Abstract:
1. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, the method comprising expanding CD 34+ hematopoietic stem cells and/or hematopoietic progenitor cells by contacting the hematopoietic stem cells in an ex vivo culture with stem cell factor (SCF) and a pyrazole compound represented by the formula (1): wherein: R R when there are two neighboring R R X is —(CR each of R each of R R when there are two neighboring R D2 is an aromatic heterocyclic rings represented by the following structural formula, F1 to F2 are rings represented by the following formulae, respectively, R R R R R R Z is a halogen atom, or C a, e, k are integers of from 1 to 5; s2 is an integer of from 0 to 3; n is an integer of 1; a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof.