Patent ID: 7611832
Filing Date: 2009-11-03
Classification: A01K,A61P,C07K,G01N

Abstract:
1. A method of identifying a compound as having cardioprotective activity comprising: (a) contacting a candidate compound with a G protein-coupled receptor (GPCR) comprising an amino acid sequence having at least 95% identity to SEQ ID NO:3, wherein said GPCR is present on a cell or isolated membrane thereof and wherein overexpression of the GPCR promotes survival of cardiomyocytes; (b) determining whether said compound stimulates the GPCR; (c) identifying a compound as having an activity that stimulates said GPCR; (d) determining whether said compound of step (c) has cardioprotective activity by: (e) identifying a compound as having cardioprotective activity.