Patent ID: 6160114
Filing Date: 2000-12-12
Classification: A61P,C07D

Abstract:
A compound of formula 1 having the structure ##STR5## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are each independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, phenylalkyl of 7-10 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy of 7-12 carbon atoms, fluoroalkoxy of 1-6 carbon atoms, trifluoromethyl, alkylthio of 1-3 carbon atoms, alkylsulfonyl of 1-3 carbon atoms, --SCF.sub.3, nitro, alkylamino in which the alkylamino moiety has 1-6 carbon atoms, or dialkylamino in which each alkyl group has 1-6 carbon atoms;R.sup.6 is hydrogen; andR.sup.7 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, or arylalkyl of 7-12 carbon atomsor a pharmaceutically acceptable salt thereof; with the proviso that at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is not hydrogen, and further provided that when any of R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is halogen, alkoxy of 1-6 carbon atoms, or nitro, at least two of R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are not hydrogen.