Patent ID: 8629157
Filing Date: 2014-01-14
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) X is NH; Ar phenyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, dioxanyl, tetrahydrofuranyl, oxazolyl, isoxazolyl, thiazolyl, pyrazolyl, pyrrolyl, imidazolyl, thienyl, thiadiazolyl, triazolyl, thiomorpholinyl, 1,1-Dioxo-1λ Ar benzoxazolyl, benzothiazolyl, benzimidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyrazolyl, pyrrolyl, imidazolyl, thienyl, thiadiazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, quinazolinyl, indazolyl, thieno[2,3-d]pyrimidinyl, indolyl, isoindolyl and benzofuranyl, each optionally substituted by 1-3 C L L wherein L R m is 0, 1 or 2; wherein each Ar the stereogenic carbon indicated with an arrow is in the (S) configuration; or a pharmaceutically acceptable salt thereof.