Patent ID: 6239282
Filing Date: 2001-05-29
Classification: C07D

Abstract:
process for preparing a 2-alkyl-3-aminothiophene derivative represented by the formula (1): ##STR37##wherein, R represents a hydrogen atom, alkyl group or alkoxy group which may be substituted, aromatic or non-aromatic hydrocarbon ring which may be substituted, aromatic or non-aromatic heterocyclic ring which may be substituted, each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents a hydrogen atom or straight or branched alkyl group having 1 to 12 carbon atoms, and R.sup.1 and R.sup.2, R.sup.3 and R.sup.4, R.sup.1 and R.sup.3, R.sup.1 and R.sup.4, R.sup.2 and R.sup.3 or R.sup.2 and R.sup.4 may together form a cycloalkyl group,comprising reacting a compound represented by the formula (2): ##STR38##wherein, R is as defined above,with a compound represented by the formula (3): ##STR39##wherein, each of R.sup.1a, R.sup.2a, R.sup.3a and R.sup.4a independently represents a hydrogen atom, straight or branched alkyl group having 1 to 12 carbon atoms or straight or branched alkenyl group having 1 to 12 carbon atoms, and R.sup.1a and R.sup.2a, R.sup.3a and R.sup.4a, R.sup.1a and R.sup.3a, R.sup.1a and R.sup.4a, R.sup.2a and R.sup.3a or R.sup.2a and R.sup.4a may together form a cycloalkyl group or cycloalkenyl group,in the presence of an acid, and reducing the resulting reaction mixture.