Patent ID: 8951524
Filing Date: 2015-02-10
Classification: A61K,A61P,C07K

Abstract:
1. A method for the treatment of cancers expressing the O-acetylated form of GD2 ganglioside selected in the group consisting of neuroblastomas, lymphomas, melanomas, glioblastomas and small cell lung cancers, said method comprising administering to a patient in need thereof an antibody specifically binds to O-acetylated GD2 ganglioside, wherein said antibody has the complementarity-determining regions of the H chain variable region comprising amino acid sequences represented in SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4 and has the complementarity-determining regions of the L chain variable region comprising amino acid sequences represented in SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, wherein said antibody has an affinity of at least ten times lower for the non O-acetylated form of GD2 ganglioside and wherein an effective amount of said antibody provides cytotoxic activity against said cancer cells.