Patent ID: 6562849
Filing Date: 2003-05-13
Classification: A61K,A61P,C07D

Abstract:
An amine compound of the formula (I): wherein:R1 represents a carbamoyl group (which may have one or two substituents &agr; described later), a thiocarbamoyl group (which may have one or two substituents &agr; described later), a sulfonyl group (which has one substituent &agr; described later) or a carbonyl group (which has one substituent &agr; described later); R2 and R3 each represent a hydrogen atom, a C1--C10 alkyl group, a C6-C10 aryl group (which may have from 1 to 3 substituents &bgr; described later) or a C7-C16 aralkyl group (which may have from 1 to 3 substituents &bgr; described later on the aryl portion); W1, W2 and W3 each represent a single bond or a C1-C8 alkylene group; X, Y and Q each represent an oxygen atom or a sulfur atom; Z represents a &boxH;CHâ€” group or a nitrogen atom; Ar represents a benzene ring or a naphthalene ring; L represents from 1 to 4 substituents on the Ar ring and the or each substituent is a hydrogen atom, a C1-C6 alkyl group, a C6-C10 aryl group (which may have from 1 to 3 substituents &bgr; described later) or a C7-C16 aralkyl group (which may have from 1 to 3 substituents &bgr; described later on the aryl portion); the substituent a represents (i) a C1-C10 alkyl group, (ii) a C1-C6 halogenoalkyl group, (iii) a C3-C10 cycloalkyl group, (iv) a C6-C10 aryl group (which may have from 1 to 3 substituents &ggr; described later), (v) a C7-C16 aralkyl group (which may have from 1 to 3 substituents &ggr; described later on the aryl portion), (vi) a C4-C11 cycloalkylcarbonyl group, (vii) a C7-C11 arylcarbonyl group (which may have from 1 to 3 substituents &ggr; described later on the aryl portion), (viii) a C8-C17 aralkylcarbonyl group (which may have from 1 to 3 substituents &ggr; described later on the aryl portion), (ix) an aromatic heterocyclic group (which may have from 1 to 3 substituents &ggr; described later), (x) an aromatic heterocyclic carbonyl group (which may have from 1 to 3 substituents &ggr; described later), (xi) a C1-C6 alkylsulfonyl group, (xii) a C1-C6 halogenoalkylsulfonyl group, (xiii) a C6-C10 arylsulfonyl group (which may have from 1 to 3 substituents &ggr; described later on the aryl portion), or (xiv) a C7-C16 aralkylsulfonyl group (which may have from 1 to 3 substituents &ggr; described later on the aryl portion); the substituent &bgr; represents (i) a C1-C6 alkyl group, (ii) a C1-C6 halogenoalkyl group, (iii) a C1-C6 alkoxy group, (iv) a halogen atom, (v) a hydroxyl group, (vi) a C6-C10 aryl group (which may have from 1 to 3 substituents &dgr; described later), (vii) a C7-C16 aralkyl group (which may have from 1 to 3 substituents &dgr; described later on the aryl portion), (viii) a cyano group, (ix) a nitro group, or (x) an amino group (which may have one or two substituents &dgr; described later); the substituent &ggr; represents (i) a C1-C6 alkyl group, (ii) a C1-C6 halogenoalkyl group, (iii) a C1-C6 alkoxy group, (iv) a halogen atom, (v) a hydroxyl group, (vi) a cyano group, (vii) a nitro group, (viii) a C3-C10 cycloalkyl group, (ix) a C6-C10 aryl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents), (x) a C7-C16 aralkyl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents on the aryl portion), (xi) a C1-C7 aliphatic acyl group, (xii) a C1-C7 aliphatic acyloxy group, (xiii) an amino group, (xiv) a di-(C1-C6 alkyl)amino group or (xv) a C1-C4 alkylenedioxy group; the substituent &dgr; represents (i) a C1-C10 alkyl group, (ii) a C6-C10 aryl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents), (iii) a C7-C16 aralkyl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents on the aryl portion), (iv) a C1-C7 aliphatic acyl group, (v) a C4-C11 cycloalkylcarbonyl group, (vi) a C7-C11 arylcarbonyl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents), (vii) a C8-C17 aralkylcarbonyl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents on the aryl portion), (viii) an aromatic heterocyclic carbonyl group (which may have from 1 to 3 C1-C6 alkyl groups, C1-C6 halogenoalkyl groups, C1-C6 alkoxy groups or halogen atoms as the substituents); or a pharmacologically acceptable salt thereof.