Patent ID: 8574588
Filing Date: 2013-11-05
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A non-glycosylated fusion protein comprising a portion of at least one flagellin selected from the group consisting of a Salmonella typhimurium flagellin type 2 (fljB/STF2), an E. coli fliC, and a S. muenchen fliC and at least a portion of at least one Dengue viral envelope protein selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein, wherein the portion of the flagellin is a Toll-like Receptor 5 agonist, the portion of the Dengue viral envelope protein is an antigen, and wherein the fusion protein activates Toll-like Receptor 5 and induces antibodies that neutralize a Dengue virus.