Patent ID: 6602852
Filing Date: 2003-08-05
Classification: A61P,C07K

Abstract:
An NST300 compound capable of selectively binding to membranes upon CMLA loss of the general formula I comprising the following components:X1â€”[(X3)a/(X4)b]wherein:X1 stands for a saturated or unsaturated fatty acid residue comprising 6-20 carbon atoms; or a cysteine residue bound through a thioether bond to a prenyl group comprising 5-20 carbon atoms; said residue being linked to the adjacent component of the compound through an amide bond; X3 comprises 1-6 amino acids, of which 1-6 are positively charged, the other amino acid residues being polar uncharged amino acids; and X4 comprises 1-6 amino acids, of which 1-2 are aromatic amino acids, the other amino acids being selected among polar uncharged amino acids and hydrophobic amino acids; â€ƒwherein: a stands for an integer of 1-8; b stands for an integer of 1-8; and (X3)a comprises at least 6 positively charged amino acids; the groups X3 and X4 being located at various places in the compound, wherein the compound is capable of binding to a cell membrane having a loss of cell membrane lipid asymmetry (CLMA).