Patent ID: 6455701
Filing Date: 2002-09-24
Classification: C07C,C07D

Abstract:
A compound of the formula wherein R1 is C1-10alkyl, 1-adamantyl, 2-tetrahydropyranoxy, trialkylsilanyloxy where alkyl has up to 6 carbons, OH, alkoxy where the alkyl group has up to 10 carbons, alkylthio where the alkyl group has up to 10 carbons, or OCH2OC1-6alkyl;R2 is lower alkyl of 1 to 6 carbons, F, Cl, Br, I, CF3, CF2CF3, NO2, N(R3)2, CN, N3, COR3, or NHCOR3, COOH, COOR3; X is S, or O; Z is â€”Câ‰¡Câ€”, â€”(CR3&boxH;CR3) â€”COâ€”NR3â€”, â€”COOâ€”, R3 is independently H or lower alkyl of 1 to 6 carbons; Y2 is pyridyl being unsubstituted or substituted with one or two R2 groups; Y3 is phenyl or naphthyl said phenyl or naphthyl groups being unsubstituted or substituted with one to three R4 groups, where R4 is alkyl of 1 to 10 carbons, fluoro-substituted alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons and having 1 to 3 double bonds, alkynyl having 2 to 10 carbons and 1 to 3 triple bonds, F, Cl, Br, I, NO2, CN, NR3, N3, COOH, COOC1-6alkyl; OH, SH, OC1-6alkyl, SC1-6alkyl; A is (CH2)8, where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds, and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, â€”CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CH(OR13O), â€”COR7, CR7(OR12)2, CR7(OR13O), or Si(C1-6alkyl)3, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons or (trimethylsilyl)alkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl, hydroxyphenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, or a pharmaceutically acceptable salt of said compound.