Patent ID: 8854617
Filing Date: 2014-10-07
Classification: B82Y,G01N,Y10T

Abstract:
1. A surface enhanced Raman scattering (SERS) marker comprising a metal particle; a self-assembled monolayer on the metal particle, the self-assembled monolayer consisting essentially of moieties comprising a Raman-active reporter group Ra and a group X which couples the moiety to the metal particle, wherein X can be comprised in Ra; an encapsulant surrounding the self-assembled monolayer, wherein the encapsulant is directly bound to the moieties comprising Ra; and a group Y which allows coupling of the SERS marker to a binding molecule; wherein the self-assembled monolayer consisting essentially of moieties comprising a Raman-active reporter group Ra comprises at least 85% the number of Raman-active reporter groups Ra compared with a metal particle entirely covered with a self-assembled monolayer formed solely of said moieties comprising Ra.