Patent ID: 8173635
Filing Date: 2012-05-08
Classification: A61P,C07D

Abstract:
1. A compound represented by structural formula I: or a pharmaceutically acceptable salt thereof wherein: A and A′ are independently —N— or —C(R R T1 is absent or a C1-10 aliphatic wherein one or more methylene units of T1 are optionally and independently replaced by G wherein G is —O—, —S(O) Q1 is absent or a 3-8 membered saturated, partially saturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from the groups consisting of O, N, and S, or an 8-12 membered saturated, partially saturated, or fully unsaturated bicyclic ring having 0-5 heteroatoms independently selected from the group consisting of O, N, and S, wherein Q1 is optionally and independently substituted with one or more J R each R R each R each J each J each R each R each R′ is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R^ is independently —H, C1-10 alkyl, or aralkyl wherein each R^ is optionally and independently substituted with up to five halogen groups; each R″ is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R* is independently —H or C-10 alkyl optionally and independently substituted with up to five halogen groups; x is 0 or 1; y is 0, 1 or 2; each n is independently 0, 1, 2, or 3; and each p is independently 0, 1, or 2.