Patent ID: 7732604
Filing Date: 2010-06-08
Classification: A61P,C07D

Abstract:
1. A compound of the formula I: wherein: R R R R R R each n is independently 0, 1, 2, 3 or 4; wherein 3-8 membered heteroalicyclic and 3-8 membered heterocycle are independently selected from the group consisting of aziridinyl, oxetanyl, thiapanyl, azepanyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrolidinyl, tetrahydropyranyl, tetrahydrothioipyranyl, piperidinyl, 1,4-dioxanyl, 1,4-oxathianyl, morpholinyl, 1,4-dithianyl, piperazinyl, 1,4-azathianyl, azepanyl, 1,4-oxaazepanyl, 1,4-dithiepanyl, 1,4-thieazapanyl, 1,4-diazepanyl, 3,4-dihydro-2H-pyranyl, 5,6-dihydro-2H-pyranyl, 2H-pyranyl, 1,2,3,4-tetrahydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2-dihydropyridyl, and imidazolidinyl; wherein 8-10 membered heterobicyclic is selected from the group consisting of benzofuranyl, benzothiphenyl, indolyl, benzimidazolyl, indazolyl, benzotriazolyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[3,2-b]pyridinyl, pyrrolo[3,2-c]pyridinyl, imidazo[4,5-b]pyridinyl, imidazo[4,5-c]pyridinyl, pyrazolo[4,3-d]pyridinyl, pyrazolo[4,3-c]pyridinyl, pyrazolo[3,4-c]pyridinyl, pyrazolo[3,4-b]pyridinyl, isoindolyl, Quinolinyl, isoquinoliinyl, quinazolinyl, quinaxolinyl, indazolyl, purinyl, indolininyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, pyrrolo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 3H-indolyl, indolyl, isoindolinyl, 2,3-dihydrobenzofuranyl, 1,3-dihydrobenzofuranyl, 1H-isoindolyl, 1,2,3,4-tetrahydroquinoxalinyl, 1,2-dihydroquinoxalinyl, 1,2-dihydroquinazolinyl, 3,4-dihydroquinazolinyl, 3,3a-dihydropyrazolo[1,5-a]pyrimidinyl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazinyl, octahydropyrrolo[1,2-a]pyrazine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl, and 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine; wherein 5-7 membered heteroaryl is selected from the group consisting of pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, thiazolyl, 1,2,3-triazolyl, 1,3,4-triazolyl, 1-oxa-2,3-diazolyl, 1-oxa-2,4-diazolyl, 1-oxa-2,5-diazolyl, 1-oxa-3,4-diazolyl, tetrazolyl, pyridinyl, pyridazinyl, and pyrimidinyl; or a pharmaceutically acceptable salt thereof.