Patent ID: 9181636
Filing Date: 2015-11-10
Classification: A61F,A61L,D01D,D01F

Abstract:
1. A method of preparing an osteoinductive and osteoconductive scaffold to facilitate bone repair, the method comprising the steps: (a) preparing a ceramic-polymer solution comprising a bioactive ceramic component comprising from about 10-50% (w/w) of a 20:80 ratio of hydroxyapatite (HA)/tricalcium phosphate (TCP), and a polymer component comprising from about 50-90% (w/w) of polycaprolactone (PCL) dissolved in a solvent selected from the group consisting of methylene chloride (MC), dimethyl formamide (DFM), and a combination thereof; and (b) electrospinning the ceramic-polymer solution, and thereby forming a ceramic-polymer composite, and depositing a three-dimensional nonwoven matrix of micron sized electrospun fibers comprising the ceramic-polymer composite on a collector, the three dimensional-nonwoven matrix of electrospun fibers including a plurality of micron sized pores, each micron sized pore of the plurality of micron sized pores having a pore size of at least about 20 microns in diameter.