Patent ID: 6117889
Filing Date: 2000-09-12
Classification: A61K,C07D

Abstract:
An -azabicyclo(2.2.1)-heptane or -heptene compound of the formula: ##STR54## wherein: R.sup.1 and R.sup.4 are independently hydrogen or alkyl;R.sup.3, R.sup.5 and R.sup.6 are independently hydrogen, alkyl, alkylhydroxy, alkyloxyalkyl, alkylthioalkyl, alkylamino, alkylaminoalkyl or alkylaminodialkyl, oxyalkyl, thioalkyl, halo, haloalkyl, NH.sub.2, alkylamino or dialkylamino, cyclic dialkylamino, ##STR55## amidine, ##STR56## --CO.sub.2 H; CO.sub.2 alkyl, --C(O)alkyl, --CN, --C(O)NH.sub.2, --C(O)NH(alkyl), --C(O)N(alkyl).sub.2, allyl, --SO.sub.2 (alkyl), --SO.sub.2 aryl, --S(O)alkyl, --S(O)aryl, aryl; or ##STR57## or pyridyl unsubstituted or substituted with halo, oxyalkyl, or CO.sub.2 alkyl,R.sub.5 and R.sub.6 together are optionally alkylidene or haloalkylidene, epoxide (--O--), episulfide (--S--); imino (--N(alkyl)-- or --N(H)--;R.sub.2 is Q;R.sup.7 is --CH.sub.2 CH.sub.2 (C.sub.6 H.sub.5), alkylamino(alkyl).sub.2, alkyloxyalkyl, alkylthioalkyl, dialkyl to from a quaternary ammonium; ##STR58## wherein R.sup.9 is hydrogen or alkyl; wherein Y' is CN, NO.sub.2, alkyl, OH, --O-alkyl;wherein Z is O or S;wherein R.sup.10 and R.sup.11 are each independently --O, --OH, --O-alkyl, --O-aryl, --NH.sub.2, --NH(akyl), --N(alkyl).sub.2, --NH(aryl) and --N(aryl).sub.2 ;wherein Q is ##STR59## and wherein the Q moiety is optionally substituted with 1 to 3 W substituents; andW is alkyl, halo, aryl, OH, oxyalkyl, SH, thioalkyl, --SO(alkyl), --SO.sub.2 alkyl, OCH.sub.2 CH.dbd.CH.sub.2, --OCH.sub.2 (C.sub.6 H.sub.5), CF.sub.3, CN, alkylenedioxy, --CO.sub.2 H, --CO.sub.2 alkyl, --OCH.sub.2 CH.sub.2 OH, --NO.sub.2, --NH.sub.2, --NH(alkyl), --N(alkyl).sub.2, NHC(O)alkyl, --SO.sub.2 CF.sub.3, or --NHCH.sub.2 aryl, and wherein the - - - indicates an optional double bond.