Patent ID: 6538116
Filing Date: 2003-03-25
Classification: A61K,A61P,C07C

Abstract:
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 on a monomeric basis, wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than 25, wherein a substituent Q is attached to the tertiary carbon and consists of a chain moiety containing from 1 to 12 chain atoms consisting of 1 to 10 carbon atoms, 0 to 2 nitrogen atoms, and 0 to 2 oxygen atoms covalently bonded to a cyclic moiety which is monocyclic, bicyclic, tricyclic, tetracyclic or pentacyclic, and contains 5 to 24 ring atoms consisting of 2 to 20 carbon atoms, 0 to 4 nitrogen atoms, 0 to 1 oxygen atoms and 0 to 1 sulfur atoms, which is obtained by nitrosylating a tertiary carbon of a therapeutic agent without NO donor effect or of said agent modified to modify the carbon acid pKa thereof, said C-nitroso compound being in dimeric form where two moieties of the same chemical composition are joined by nitrogen to nitrogen bonding.