Patent ID: 7374770
Filing Date: 2008-05-20
Classification: A61K,A61P,A61Q,Y10S

Abstract:
1. A topical composition for follicular delivery of an ornithine decarboxylase inhibitor to an area of mammalian skin containing hair follicles, the composition comprising: a) an amount of an ornithine decarboxylase inhibitor selected from the group consisting of 2-(difluoromethyl)-2,5 -diaminopentanoic acid, alpha-ethynyl ornithine, 6heptyne-2,5-diamine,2-methyl-6-heptyne-2,5-diamine, and pharmaceutically acceptable salts, hydrates, optical enantiomers, and racemic mixtures thereof sufficient to deliver 1 to 2000 micrograms of the omithine decarboxylase inhibitor per square centimeter (cm b) 1.0 to 25% of a follicular delivery enhancer, which provides a follicular enhancement ratio of at least 1.3 and is selected from the group consisting of poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, steareth-100, and mixtures thereof; and c) a pharmaceutically acceptable carrier.