Patent ID: 8648087
Filing Date: 2014-02-11
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: A is O, C(═O), S, SO or SO G is N; B represents a fused 6-membered aryl ring; E is X is N or CH; D D D R each R each R wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl are optionally substituted with one or more groups independently selected from halogen, oxo, cyano, nitro, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, saturated or partially unsaturated cycloalkyl, saturated and partially unsaturated heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, trifluoromethoxy, difluoromethoxy, fluoromethoxy, trifluoromethyl, difluoromethyl, fluoromethyl, OR or R Q is Z is selected from and tautomers thereof; W and V are independently O, NR W Y is S, SO, SO provided that when W is O, NR when V is O, NR R each R or R R R or R or R or R or R or R each R R R wherein said alkyl, cycloalkyl and heterocyclyl portions are optionally substituted with one or more groups independently selected from halogen, cyano, nitro, trifluoromethyl, difluoromethyl, fluoromethyl, fluoromethoxy, difluoromethoxy, trifluoromethoxy, azido, oxo, OR R or any two of R or R R or R each R each R R or NR or NR j is 0, 1, 2 or 3; m is 1, 2, 3, or 4; n is 0, 1, 2, 3, or 4; q is 0, 1, 2, 3, 4, or 5; and p is 0, 1 or 2; wherein when said compound of Formula I is represented by the formula and R 3 is other than Q or Z, then E is not a benzofuranyl, indolyl, quinazolinyl, quinolinyl, or isoquinolinyl ring.