Patent ID: 6034060
Filing Date: 2000-03-07
Classification: A61K,A61P,C07K

Abstract:
A peptide having the ability to promote the activation of protein C by thrombin, comprising an amino acid sequence represented by the following formula (I):Val Glu Pro Val Asp Pro Cys Phe Arg Ala (I) - Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn - Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu - Gly Phe Ala Pro Ile Pro His Glu Pro His - Arg Cys Gln Met Phe Cys Asn Gln Thr Ala - Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln - Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile - Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile - Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser - Gly Val Cys His Asn Leu Pro Gly Thr Phe - Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu - Val Arg His Ile Gly Thr Asp Cys, and not containing an amino acid sequence represented by the formula:Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu - Cys Leu Val Val Ala Leu Leu Ala Leu Leu - Cys His Leu Arg Lys Lys Gln Gly Ala Ala - Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala - Pro Ser Lys Glu Val Val Leu Gln His Val - Arg Thr Glu Arg Thr Pro Gln Arg Leu.