Patent ID: 8034619
Filing Date: 2011-10-11
Classification: C12N

Abstract:
1. A method for treatment of NF-κB-associated diseases which comprises administering to an animal an effective amount of a concatemerized NF-κB chromosomal binding site decoy which antagonizes NF-κB-mediated transcription of a gene located downstream of a NF-κB binding site, wherein the concatemerized decoy comprises two or more end-to-end repeated copies of a domain, wherein each of the domains comprises a nucleotide sequence that acts as a NF-κB binding site decoy, wherein the concatemerized decoy is delivered by a polymeric vector, wherein the polymeric vector is a polyhydroxylamidoamine selected from the group consisting of a poly(L-tartaramidoamine) depicted by the following structural formula: wherein n is 1 or greater than 1, a poly(D-glucaramidoamine) depicted by the following structural formula: wherein n is 1 or greater than 1, a poly(galactaramidoamine) depicted by the following structural formula: wherein n is 1 or greater than 1, and a poly(D-mannaramidoamine) depicted by the following structural formula: wherein n is 1 or greater than 1.