Patent ID: 6821972
Filing Date: 2004-11-23
Classification: A61P,C07D

Abstract:
A compound of formula (I): or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in which,X is C1-6 alkylene or C2-6 alkenylene, each of which is unsubstituted or substituted by one or more fluorine atoms; R is aryl, C5-8 cycloalkenyl or C3-8 cycloalkyl unsubstituted or substituted by one or more fluorine atoms; wherein aryl comprises phenyl unsubstituted or substituted by one or more substituents independently selected from the group consisting of R1, OH, SO2(C1-4 alkyl) and C(O)p(C1-4 alkyl) groups; wherein p=0, 1 or 2; [HET] is a divalent heterocyclic moiety selected from: wherein Z is H or C1-4 alkyl; Y is a mono- or bicyclic unsaturated ring system containing from 5 to 10 ring atoms, of which up to 4 of said ring atoms are hetero-atoms independently selected from the group consisting of N, O and S, and said ring system is unsubstituted or substituted by one or more substituents independently selected from the group consisting of &boxH;O, C1-4 alkyl, C1-4 alkoxy, NR1R2, SO2NR1R2, CO2R1, CONR1R2, CH2CO2R1, NR1CO2R2, NR1SO2R2 and het1; wherein R1 and R2 are each independently selected from H or C1-4 alkyl unsubstituted or substituted by C1-4 alkoxy; wherein het1 is a N-linked 4- to 6-membered mono- or bicyclic heterocycle unsubstituted or containing 1 or 2 further hetero ring atoms independently selected from the group consisting of N and O, which heterocycle is unsubstituted or substituted by one or more substituents independently selected from the group consisting of &boxH;O, C1-4 alkyl, C1-4 alkoxy, NR1R2, SO2NR1R2, CO2R1, CONR1R2, CH2CO2R1, NR1CO2R2, NR1SO2R2 and het2; wherein het2 is a N-linked 4- to 6-membered mono- or bicyclic heterocycle unsubstituted or containing 1 or 2 further hetero ring atoms independently selected from the group consisting of N and O.