Patent ID: 7459444
Filing Date: 2008-12-02
Classification: A61P,C07F

Abstract:
1. A compound of Formula (I) wherein R  is selected from the group consisting of aryl, heteroaryl, benzo fused heterocyclyl, cyclopropyl when n is 0 and one of R R R Cy is a heterocyclyl optionally substituted with a substituent selected from the group consisting of C and any one of the foregoing C 1-6 alkyl- or C 1-6 alkoxy-containing substituents of R 14 is optionally substituted on a terminal carbon atom with a substituent selected from —NR 29 R 30 , aryl, heteroaryl, one to three halogen atoms, or hydroxy; wherein R 29 and R 30 are independently hydrogen; C 1-6 alkyl optionally substituted with hydroxy, aryl, —C(═O)C 1-4 alkoxy, NH 2 , NH(C 1-6 alkyl), or —N(C 1-6 )dialkyl; or aryl; and R 29 and R 30 are optionally taken together with the atoms to which they are attached to form a ring of five to seven members; n is 0 or 1; W is O or S; X is hydrogen or C Y is independently selected from SO R R Z is a seven to fifteen membered monocyclic or polycyclic ring system selected from the group consisting aryl, heteroaryl, benzo fused heterocyclyl, or benzo fused cycloalkyl; and pharmaceutically acceptable salts thereof.