Patent ID: 8515508
Filing Date: 2013-08-20
Classification: A61B,G01N

Abstract:
1. A method for measuring a concentration of a biological substance contained in a living body having a particle chip implanted therein, wherein the particle chip includes on the surface thereof, a plurality of particles each of which has a longitudinal axis, the method comprising steps of: applying a linear-polarized light to the particle chip; modulating, before the step of applying the linear-polarized light, a polarization direction of the linear-polarized light, in order to cause an angle θ to be periodically varied over time t through rotation of the polarization direction, wherein the angle θ is formed by the polarization direction and a direction x, and the longitudinal axes of the particles are oriented in the direction x; receiving a surface enhanced Raman scattering light generated from emission on the particle chip of the linear-polarized light that has undergone the rotation of its polarization direction in the step of modulating, to obtain a signal of the surface enhanced Raman scattering light; and calculating the concentration of the biological substance based on a magnitude of the obtained signal in the step of receiving, which varies in response to the periodically varied angle θ.