Patent ID: 8841459
Filing Date: 2014-09-23
Classification: A61P,C07D

Abstract:
1. A method of treating a subject with a hyperproliferative disease comprising administering to the subject an effective amount of a MEK inhibitor, wherein the hyperproliferative disease is related to the hyperactivity of MEK and diseases modulated by the MEK cascade in mammals, and wherein the MEK inhibitor is a compound according to Formula (II): or a pharmaceutically acceptable salt thereof, wherein: R provided that R R R R R W is selected from —C(O)OR provided that W is not —C(O)OH; R R′ and R″ are independently selected from hydrogen, C X is N or N j is 1 or 2, with the proviso that 3-Phenylamino-isonicotinic acid methyl ester and 3-Oxo-3-(3-phenylamino-pyridin-4-yl)-propionic acid ethyl ester are not included.