Patent ID: 6177425
Filing Date: 2001-01-23
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR11##(relative stereochemistry indicated)wherein:R.sup.1 represents C.sub.1-6 alkyl;R.sup.2 represents C.sub.2-4 alkyl or C.sub.2-4 alkenyl;X represents CO or SO.sub.2 ;R.sup.3 represents:(a) C.sub.2-8 alkenyl NR.sup.4 R.sup.5 ;(b) phenyl substituted by (CH.sub.2).sub.a Q(CH.sub.2).sub.b NR.sup.4 R.sup.5(c) a 5 or 6 membered heterocyclic aromatic ring containing 1 or 2 heteroatoms selected from N, S and O substituted by (CH.sub.2).sub.a Q(CH.sub.2).sub.b NR.sup.4 R.sup.5 ;(d) phenyl substituted by NHCOC.sub.1-8 alkyl;(e) a group as defined in (b), (c), or (d) further substituted on the phenyl or heterocyclic ring by one or more groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen and nitro; or(f) C.sub.1-8 alkylNR.sup.4 R.sup.5 ;R.sup.4 and R.sup.5 independently represent hydrogen, C.sub.1-8 alkyl, --(CH.sub.2).sub.1-4 CONR.sup.6 R.sup.7, COC.sub.1-4 alkyl or (CH.sub.2).sub.0-2 Ph where Ph represents phenyl optionally substituted by one or more C.sub.1-4 alkyl or halogen groups or NR.sup.4 R.sup.5 together represents azetidinyl, pyrrolidinyl, piperidinyl, azepinyl, morpholinyl, piperazinyl or N--C.sub.1-6 alkyl-piperazinyl or such a heterocyclic ring optionally substituted by one or more C.sub.1-4 alkyl, CONR.sup.6 R.sup.7 or COOR.sup.6 groups;Q represents a bond, S, O or NR.sup.8 ;a represents 0 to 4 and b represents 2 to 4 save that a+b lies in the range 2 to 6 except when Q represents a bond in which case b may also represent 0 or 1 and a+b may lie in the range 0 to 6;R.sup.6, R.sup.7 and R.sup.8 independently represent hydrogen or C.sub.1-4 alkyl;and salts and solvates thereof.