Patent ID: 6525200
Filing Date: 2003-02-25
Classification: C07D

Abstract:
A multicyclic aromatic compound comprising the formula: wherein R1, R2 and R3 are the same or different and at least one is selected from the group consisting of a hydrophillic substituent, a directly or indirectly linked quencher molecule, a substituted or unsubstituted heterocyclic ring structure, and a combination thereof, with the remainder being hydrogen, wherein R1â€², R2â€² and R3â€² are the same or different and at least one is selected from the group consisting of a hydrophillic substituent, a substituted or unsubstituted heterocyclic ring structure, a directly or indirectly linked fluorophore, R1â€² and R2â€² together form a five- or six-membered cyclic ring fused to a substituted or unsubstituted heterocyclic ring structure, and a combination thereof, with the remainder being hydrogen; wherein R4 and R4â€² are the same or different and are selected from the group consisting of hydrogen, a hydrophillic substituent, a substituted or unsubstituted heterocyclic ring structure, a directly or indirectly linked quencher molecule, a directly or indirectly linked fluorophore and a combination thereof, or R4 and R4â€² together form a five- or six-membered cyclic ring fused to a substituted or unsubstituted heterocyclic ring structure; wherein A and Aâ€² are the same or different and are selected from the group consisting of carbon, nitrogen, oxygen, sulfur and a combination thereof; wherein X and Xâ€² are the same and different and are a substituted or unsubstituted chain of 0 to 10 atoms selected from the group consisting of carbon, nitrogen, oxygen, sulfur, and a combination thereof; wherein R1 and R1â€² are not both selected from the group consisting of a carboxy group, a carboxylate and a combination thereof, when R2, R2â€², R3, R3â€², R4, and R4â€² are hydrogen, A and Aâ€² are methylene, and X and Xâ€² are methylene; and wherein R1 is not selected from the group consisting of a carboxy group and a carboxylate, when R1â€² is a substituted heterocyclic ring structure being a pyridine with substituents other than amines or alcohols.