Patent ID: 6235770
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
An indolyl-substituted phenylacetic acid compound of the formula: ##STR248##in whichR.sup.10 and R.sup.11 are identical or different and represent hydrogen, trifluoromethyl, halogen, or straight-chain or branched alkyl or alkoxy having in each case up to 6 carbon atoms;R.sup.8 and R.sup.9 are identical or different and represent hydrogen, cycloalkyl having 3 to 6 carbon atoms, phenyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or straight-chain or branched alkyl having up to 6 carbon atoms, which alkyl is optionally substituted by halogen;E and L are identical or different and represent hydrogen, halogen, trifluoromethyl, hydroxyl, or carboxyl, or represent straight-chain or branched alkyl, alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms;R.sup.1 represents cycloalkyl having 3 to 10 carbon atoms, straight-chain or branched alkyl having 1 to 10 carbon atoms, or phenyl, which phenyl is optionally substituted once or twice by identical or different substituents independently selected from the group consisting of halogen, cyano, hydroxyl, and straight-chain or branched alkyl or alkoxy having in each case up to 4 carbon atoms;R.sup.2 represents hydrogen or straight-chain or branched alkyl having up to 3 carbon atoms;R.sup.3 represents hydrogen, straight-chain or branched alkyl having up to 5 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, or phenyl, which phenyl is optionally substituted one to three times by identical or different substituents independently selected from the group consisting of halogen, nitro, phenyl, hydroxyl, or straight-chain or branched alkyl or alkoxy having up to 6 carbon atoms;R.sup.4 represents hydrogen, a group of the formula --CH.sub.2 --OH, or a group of the formula --CH.sub.2 --O--CO--R.sup.12 ;whereinR.sup.12 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, or phenyl, which phenyl is optionally substituted one to three times by identical or different substituents independently selected from the group consisting of halogen, hydroxyl, cyano, or straight-chain or branched alkyl or alkoxy having in each case up to 4 carbon atoms;or a salt thereof.