Patent ID: 8828932
Filing Date: 2014-09-09
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A pharmaceutical composition comprising a polypeptide comprising: a first domain comprising a portion of soluble CD4, wherein said portion of soluble CD4 comprises the D1D2 domain of soluble CD4; a second domain comprising a human immunodeficiency virus (HIV) gp41 functional domain-binding sequence selected from the group consisting of N-terminal heptad repeat (NHR)-binding peptides, C-terminal heptad repeat (CHR)-binding peptides and fusion peptide (FP)-binding peptides; and a flexible linker linking the amino acid sequences of said first domain and said second domain, wherein said linker comprises the amino acid sequence (GGGGS) wherein the polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:37-62.