Patent ID: 6159971
Filing Date: 2000-12-12
Classification: A61K,A61P

Abstract:
A combination comprising a first component (a) which is a 5-HT reuptake inhibitor and a second component (b) which is a selective h5-HT.sub.1B antagonist or partial agonist having the formula I ##STR35## wherein X is CH.sub.2, or O; Y is CONH, or NHCO;R.sub.1 is H, C.sub.1 -C.sub.6 alkyl, or C.sub.3 -C.sub.6 cycloalkyl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, or halogen;R.sub.3 is ##STR36## R.sub.4 and R.sub.5 independently are H or C.sub.1 -C.sub.4 alkyl, wherein the component (b) is in the racemate, R-enantiomer or S-enantiomer form, and wherein said components (a) and (b) are in the form of a free base, solvate or pharmaceutically acceptable salt thereof.