Patent ID: 6063785
Filing Date: 2000-05-16
Classification: C07D

Abstract:
A compound of Formula I ##STR44## wherein: R.sup.1 is hydrogen, halogen, C.sub.1-5 alkoxy, hydroxyl, or C.sub.1-5 alkyl;R.sub.2 is C.sub.1-6 alkyl, substituted C.sub.1-6 alkylwhere the alkyl substituents are independently selected from one or more halogens,phenyl,substituted phenylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl,phenylC.sub.1-5 alkyl, orsubstituted phenylC.sub.1-5 alkylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, halogen, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl;R.sub.3 is hydrogen, hydroxy or C.sub.1-5 alkoxy if the dashed line is absent or is oxygen if the dashed line is present;R.sub.4 is hydrogen, C.sub.1-5 alkyl, phenylC.sub.1-5 alkyl or substituted phenylC.sub.1-5 alkylwhere the phenyl substitutents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl;R.sub.5 is hydrogen, halogen, hydroxy, C.sub.1-8 alkyl, substituted C.sub.1-8 alkylwhere the alkyl substitutents are independently selected from one or more halogens,C.sub.1-5 alkoxy, amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, C.sub.1-5 alkylcarbonyl, C.sub.1-5 alkoxycarbonyl, nitrile, or nitro;R.sub.6 is hydrogen, halogen, hydroxy, C.sub.1-8 alkyl, substituted C.sub.1-8 alkylwhere the alkyl substitutents are independently selected from one or more halogens, C.sub.1-5 alkoxy, amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, C.sub.1-5 alkylcarbonyl, C.sub.1-5 alkoxycarbonyl, or nitro;R.sub.7 is hydrogen, halogen, hydroxy, C.sub.1-8 alkyl, substituted C.sub.1-8 alkylwhere the alkyl substitutents are independently selected from one or more halogens, C.sub.1-5 alkoxy, amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, C.sub.1-5 alkylcarbonyl, C.sub.1-5 alkoxycarbonyl, or nitro;A is nitrogen or carbon;B is nitrogen or carbon,E is nitrogen or carbon;with the proviso that if A is nitrogen, B and E are carbon, if B is nitrogen A and E are carbon or if E is nitrogen, A and B are carbon,pharmaceutically acceptable salts thereof; and stereoisomers, racemic mixtures, as well as enantiomers thereof.