Patent ID: 6607710
Filing Date: 2003-08-19
Classification: A61K,A61P,C07B,C07F

Abstract:
A bisphosphonic acid derivative or salt thereof represented by the following formula (1):Râ€”Yâ€”Aâ€ƒâ€ƒ(1) wherein A is a bisphosphonic acid or salt thereof, having a Pâ€”Câ€”P bond; Y is a bonding portion selected from the group consisting of â€”(CH2)â€”, â€”[(CH2)m(NHCO)r(CH2)n]qâ€”, â€”[(CH2)m(CONH)r(CH2)n]qâ€” and â€”(CH2)oâ€”Sâ€”(CH2)pâ€”; k, l, m, n, o, p, q and r each represents independently an integer, and k=0 or 1, l=1 to 6, m=0 to 6, n=1 to 6, o=0 to 6, p=0 to 6, q=1 to 6, and r=1 to 6; R is a group of any one of compounds selected from the group consisting of a polyaminopolycarboxylic acid, an aliphatic carboxylic acid, a mercaptoacetylpolyamino acid and a compound represented by the following formula (2), and in the formula (2), X is a halogen atom or its isotope, or an alkyl tin; Z is a group of any one of compounds selected from the group consisting of an aminocarboxylic acid, an alkylcarboxylic acid, a substituted-alkylcarboxylic acid, an alkylsulfonic acid and a substituted-alkylsulfonic acid.