Patent ID: 6849639
Filing Date: 2005-02-01
Classification: A61P,C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein g, h and j are each independently 0 or 1; provided when h is 0, then g is 0; each Alk is independently a alkyl radical; U represents guanidino, —(G-alkyl) wherein k is 0 or 1; G represents a bond, O, S or NH; Q represents O, S, NH, N—CN or N-alkyl; R is a radical of hydrogen or alkyl; R wherein R each R V represents a radical of formula wherein each W 2 , W 3 , W 4 and W 5 C—R 4 ; provided the total number of cycloalkyl, aryl, heteroaryl, heterocyclyl, carboxy, —C(O)—O—R 19 , —C(O)—R 19 , —C(O)—NH—R 19 , —C(O)—N(R 19 ) 2 and —R 19 radicals in W 2 , W 3 , W 4 and W 5 is 0-2; each W each R R A represents a radical of formula R B represents a radical of formula wherein (a) R 15 is a hydrogen or alkyl radical; and R 17 is (1) an aryl, heteroaryl, —NH—C(O)—R 19 , —C(O)—NH—R 19 , —NH—C(O)—NH—R 19 , —O—C(O)—NH—R 19 , —NH—C(O)—O—R 19 , —S(O) 2 —R 19 , —NH—S(O) 2 —R 19 , —S(O) 2 —NH—R 19 or —NH—S(O) 2 —NH—R 19 radical, or (2) an alkyl radical substituted by a radical of aryl, heteroaryl, —NH—C(O)—R 19 , —C(O)—NH—R 19 , —NH—C(O)—NH—R 19 , —O—C(O)—NH—R 19 , —NH—C(O)—O—R 19 , —S(O) 2 —R 19 —NH—S(O) 2 —R 19 , —S(O) 2 —NH—R 19 or —NH—S(O) 2 —NH—R 19 ; wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of R 2 ; or (b) R provided that when a nitrogen atom is attached to the carbon atom to which R wherein R R E is a radical of carboxy, amido, tetrazolyl, —C(O)—O—R wherein R provided that when U represents guanidino, —C(Q)—NH—R