Patent ID: 8697657
Filing Date: 2014-04-15
Classification: A61K,A61P

Abstract:
1. A method for treating ischemia and/or reperfusion injury in a subject in need thereof, the method comprising administering an effective amount of (i) an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, wherein the aromatic-cationic peptide is selected from the group consisting of: Tyr-D-Arg-Phe-Lys-NH 2 ; 2′,6′-Dmt-D-Arg-Phe-Lys-NH 2 ; Phe-D-Arg-Phe-Lys-NH 2 ; 2′,6′-Dmp-D-Arg-Phe-Lys-NH 2 ; and D-Arg-2′,6′-Dmt-Lys-Phe-NH 2 and (ii) an additional active agent consisting of cyclosporine; wherein the aromatic-cationic peptide is linked to cyclosporine by a linker.