Patent ID: 8357494
Filing Date: 2013-01-22
Classification: C07K,G01N

Abstract:
1. Isolated oligoclonal antibodies able to recognize and bind the antigenic epitope of at least one glycosylated cytoplasmic or non glycosylated nuclear isoform of human clusterin in a selective and specific way, wherein the antigenic epitope of the non glycosylated nuclear isoform is selected from the antigenic epitope consisting of SEQ ID NO: 1 (QFNWVSRLAN wherein the antigenic epitope of the glycosylated cytoplasmic isoform is selected from the antigenic epitope consisting of SEQ ID NO: 2 (TKLKELPGVCNETMMALWEE) glycosylated at its N residue, the antigenic epitope consisting of SEQ ID NO: 3 (TNEERKTLLSNLEEAK), or the antigenic epitope consisting of SEQ ID NO: 4 (METVAEKALQEYRKK), and wherein said epitope is immunogenic.