Patent ID: 6417220
Filing Date: 2002-07-09
Classification: C07D

Abstract:
A prophylactic and/or therapeutic method for treating a disease caused by mitochondrial functional abnormality, or a disease with mitochondrial functional abnormality, comprising:administering a prophylactically and/or therapeutically effective amount, to a patient in need of such treatment, of a medicament comprising as an active ingredient a substance having a stabilizing effect on mitochondrial membranes by suppressing or eliminating depolarization of mitochondrial membranes which is caused by elevation of intracellular calcium ion concentration; wherein the disease comprises abnormality of mitochondnrial enzyme activity, mitochondrial gene mutation disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), mitochondrial encephalomyopathy, Niemann-Pick's disease, renal failure, hepatic failure, or at least one of a gas poisoning, an alcoholic poisoning, a drug poisoning, a pesticide poisoning, a heavy metal poisoning, and a poisoning caused by a toxin of an animal or a plant.