Patent ID: 6472390
Filing Date: 2002-10-29
Classification: A61K,A61P

Abstract:
A method for prophylaxis or treatment of a patient with a disease of the vasculature involving constriction or proliferation of smooth muscle or other pathologic condition involving constriction or proliferation of smooth muscle, or at risk for such, except for acute thrombotic complications of restenosis or platelet embolism or other thromboembolic events, said method comprising administering to said patient an NO donor that donates nitric oxide or a related redox species and provides bioactivity that is identified with nitric oxide and which is capable of acutely lowering mean arterial blood pressure or pulmonary artery pressure by more than 10% in a therapeutically effective amount which is insufficient to acutely lower mean arterial blood pressure or pulmonary artery pressure by more than 10%, with the proviso that when the NO donor is ethyl nitrite, it is administered in a liquid, orally or by infusion.