Patent ID: 6265536
Filing Date: 2001-07-24
Classification: A61K,A61P,C07K

Abstract:
A polypeptide compound of the following general formula (SEQ ID NO:1): ##STR133##wherein R.sup.1 is lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent(s);lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least ore oxygen atom which may have one or more suitable substituent(s);lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one or more suitable substituent(s);lower alkanoyl substituted with saturated 3 to 8 membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent(s);ar(lower)alkenoyl substituted with aryl which may have one or more suitable substituent(s);naphthyl(lower)alkenoyl which may have one or more higher alkoxy;lower alkynoyl which may have one or more suitable substituent(s);(C.sub.2 -C.sub.6)alkanoyl substituted with naphthyl having higher alkoxy;ar(C.sub.2 -C.sub.6)alkanoyl substituted with aryl having one or more suitable substituent(s), in which, ar(C2-C6)alkanoyl may have one or more suitable substituent(s);aroyl substituted with heterocyclic group which may have one or more suitable substituent(s), in which aroyl may have one or more suitable substituent(s);aroyl substituted with aryl having lower alkoxy(higher)alkoxyl;aroyl substituted with aryl having lower alkyl;aroyl substituted with aryl having higher alkyl;ar(lower)alkoxy(lower)alkanoyl which may have one or more suitable substituent(s);arylamino(lower)alkanoyl which may have one or more suitable substituent(s);lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy;lower alkoxy(higher)alkanoyl, in which higher alkanoyl may have one or more suitable substituent(s);aroyl substituted with cyclo(lower)alkyl having lower alkyl; indolylcarbonyl having higher alkyl;naphthoyl having lower alkyl;naphthoyl having higher alkyl;naphthoyl having lower alkoxy(higher)alkoxy;aroyl substituted with aryl having lower alkoxy(lower)alkoxy(higher)alkoxy;aroyl substituted with aryl having lower alkoxy(lower)alkoxy;aroyl substituted with aryl which has aryl having lower alkoxy(lower)alkoxy;aroyl substituted with aryl having heterocyclicoxy(higher)alkoxy;aroyl substituted with aryl having aryloxy(lower)alkoxy;lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy;higher alkanoyl having hydroxy;higher alkanoyl having ar(lower)alkyl and hydroxy; or 3-methyl-tridecenoyl; and a pharmaceutically acceptable salt thereof.