Patent ID: 7605278
Filing Date: 2009-10-20
Classification: A61P,C07D,C07F,Y02P

Abstract:
1. A method for forming a taxane or precursor or analog thereof from a raw material, the raw material comprising a compound represented by the formula below: wherein, R R R R X=deprotonated sulfuric acid or deprotonated sulfur containing acid; deprotonated nitric acid or other nitrogen containing acid; deprotonated carboxylic acid, except trifluoro acetic acid; deprotonated phosphoric acid or any phosphorus containing acid; deprotonated tartaric acid; deprotonated p-toluene sulfonic acid; or deprotonated picric acid; and wherein said taxane or precursor or derivative thereof is in a solid, purified form; the method comprising benzoylating the raw material with a benzoylation solution comprising a benzoylating agent and a buffer such that the pH of the benzoylation solution is about 4 to about 6.