Patent ID: 6051210
Filing Date: 2000-04-18
Classification: A61K

Abstract:
% w/v to about 20% w/v of a compound selected from the group consisting of 3,5-bis(acetylmethylamino)-2,4,6-triiodo benzoic acid, the sodium salt of 3,5-bis(acetylmethylomino)-2,4,6-triiodo benzoic acid and the N-methyl-glucamine salt of 3,5,-bis(acetylmethylamino)-2,4,6-triiodo benzoic acid in bovine serum albumin,B) intravenously administering said composition to said mammal at a dosage of 40 to 80 mg iodine per kg of body weight to obtain a biodistribution:a) of from about 4.56% w/w to about 6.63% w/w of said compound per gram of blood within one minute of administration and from about 1.21% w/w to about 3.66% w/w per gram of blood within five minutes of administration;b) of from about 37.57% w/w to about 13.53% w/w of said compound per gram of tissue of kidney within one minute of administration, and of from about 21.50% w/w to about 12.65% w/w of tissue of kidney within five minutes of administration;c) of from about 15.75% w/w to about 12.30% w/w of said compound per gram of tissue of liver within one minute of administration, and of from about 15.