Patent ID: 6544780
Filing Date: 2003-04-08
Classification: A61K,A61P,C07K,C12N,Y02A

Abstract:
A recombinant adenovirus comprising:in an E1, E3 or E4 region of the adenovirus, an antigen sequence that is heterologous to a native progenitor of the recombinant adenovirus and encodes a first viral antigen from a first pathogenic virus and a second viral antigen from a second pathogenic virus, the first and second viral antigens being expressed bicistronically under transcriptional control of a first promoter located in the same region as the antigen sequence; and in an E4, E3 or E1 region of the adenovirus that does not comprise the antigen sequence, an immuno-stimulator sequence that is heterologous to the native progenitor of the recombinant virus and encodes a first immuno-stimulator, the immuno-stimulator being expressed under transcriptional control of a second promoter located in the same region as the immuno-stimulator sequence, wherein a portion of or the whole native E1, E3 or E4 region is deleted to such an extent that renders the recombinant adenovirus replication-incompetent.