Patent ID: 6596258
Filing Date: 2003-07-22
Classification: A61K,G01R,Y10T

Abstract:
A method of obtaining extracellular or intracellular pH images in a biological system by magnetic resonance, the method comprising administering to said biological system a suitable amount of an imidazole compound selected from the group consisting of whereinR1 and R2 are H or an alkyl substituent which may comprise 19F; and R is alkyl; and detecting pH by performing magnetic resonance measurement using a method selected from the group consisting of proton magnetic resonance chemical shift imaging (1H CSI), proton magnetic resonance spectroscopic imaging (1H MRSI), fluorine magnetic resonance chemical shift imaging (19F CSI), fluorine magnetic resonance spectroscopic imaging (19F MRSI), and combinations thereof to obtain a pH image.