Patent ID: 7354600
Filing Date: 2008-04-08
Classification: A61K,A61P,C08B

Abstract:
1. A thiolated mucoadhesive polymer selected from the group consisting of: a thiolated copolymer of acrylic acid and divinyl glycol, a thiolated polymer of chitosan, a thiolated polymer of sodium carboxymethylcellulose, a thiolated polymer of sodium alginate, a thiolated polymer of sodium hydroxypropylcellulose, a thiolated polymer of hyaluronic acid, and a thiolated polymer of pectin, wherein: (a) said thiolated mucoadhesive polymer comprises at least one non-terminal thiol group, and (b) said thiolated mucoadhesive polymer exhibits a total work of adhesion (TWA) of more than 120 μJ to intestinal mucosa at a pH of 7.