Patent ID: 6221870
Filing Date: 2001-04-24
Classification: A61P,C07D

Abstract:
A compound of formula I ##STR8##whereinR.sub.1 is hydrogen, (C.sub.1-4)alkyl or a group of formula ##STR9##wherein n is 1 to 4 and R.sub.7 is fluorine, chlorine, hydroxy, (C.sub.1-4)alkyl or (C.sub.1-4)alkoxy,R.sub.2 is hydrogen, chlorine, bromine, iodine, (C.sub.1-4)alkyl or (C.sub.1-4) alkylthio,R.sub.3 is hydrogen or (C.sub.1-4)alkyl,R.sub.4 is (i) a group of formula ##STR10##wherein R.sub.8 is fluorine, chlorine, nitro or cyano and R.sub.11 is (C.sub.1-4)alkyl or (C.sub.2-5)alkenyl, or (ii) a group of formula ##STR11##wherein each X independently is O or S, andR.sub.5 and R.sub.6 are each hydrogen or form together a further bond between the two carbon atoms on which they are located,in free base or acid addition salt form.