Patent ID: 6093735
Filing Date: 2000-07-25
Classification: A61K,A61P,C07D

Abstract:
A method of promoting growth, efficiency of feed utilization and/or production of lean body mass in a non-human animal, comprising administering to the non-human animal a compound of the formula: ##STR204## wherein: R.sub.1 is ##STR205## the bond between A.sub.3 and A.sub.4 is either a single or double bond; A.sub.3 and A.sub.4 are independently carbon or nitrogen;R.sub.7 is hydrogen, halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, CN, COOR.sub.2, CONHR.sub.2, NHCOR.sub.2,OR.sub.2, NHR.sub.2, SR.sub.2, SO.sub.2 R.sub.2, SO.sub.2 NHR.sub.2, or SOR.sub.2 ;R.sub.2 and R.sub.3 are independently hydrogen, C.sub.1 -C.sub.4 alkyl, or aryl;X.sub.1 is --OCH.sub.2 --, --SCH.sub.2 --, or a bond;R.sub.4 is an optionally substituted heterocycle or a moiety selected from the group consisting of: ##STR206## X.sub.2 is a bond, or a 1 to 5 carbon straight or branched alkylene; R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sub.6 is hydrogen or C.sub.1 -C.sub.4 alkyl;or R.sub.5 and R.sub.6 combine with the carbon to which each is attached to form a C.sub.3 -C.sub.6 cycloalkyl;or R.sub.6 combines with X.sub.2 and the carbon to which each is attached to form a C.sub.3 -C.sub.8 cycloalkyl;R.sub.8 is independently H, halo or C.sub.1 -C.sub.4 alkyl;R.sub.9 is halo, CN, OR.sub.10, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, CO.sub.2 R.sub.2, CONR.sub.11 R.sub.12, CONH(C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy), SR.sub.2, CSNHR.sub.2, CSNR.sub.11 R.sub.12, SO.sub.2 R.sub.2, SO.sub.2 NR.sub.11 R.sub.12, SOR.sub.2, NR.sub.11 R.sub.12, optionally substituted aryl, optionally substituted heterocycle, or C.sub.2 -C.sub.4 alkenyl substituted with CN, CO.sub.2 R.sub.2 or CONR.sub.11 R.sub.12 ;R.sup.10 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, (CH.sub.2).sub.n C.sub.3 -C.sub.8 cycloalkyl, (CH.sub.2).sub.n aryl, (CH.sub.2).sub.n heterocycle, (CH.sub.2).sub.n C.sub.3 -C.sub.8 optionally substituted cycloalkyl, (CH.sub.2).sub.n optionally substituted aryl, or (CH.sub.2).sub.n optionally substituted heterocycle;R.sub.11 and R.sub.12 are independently hydrogen, C.sub.1 -C.sub.4 alkyl, aryl, (CH.sub.2).sub.n aryl, or R.sub.11 and R.sub.12 combine with the nitrogen to which each is bound to form morpholinyl, piperidinyl, pyrrolidinyl, or piperazinyl;n is 0, 1, 2, or 3; andm is 0 or 1;or pharmaceutically acceptable salts thereof provided that when X.sub.1 is a bond then A.sub.3 and A.sub.4 are both carbon or both nitrogen.