Patent ID: 8097708
Filing Date: 2012-01-17
Classification: A61K,A61P,C07H

Abstract:
1. A 10a-azalide compound represented by the formula (I): {wherein, in the formula (I), R 1 is: hydrogen atom, a halogen atom, or a C R one of them is hydrogen atom, and the other is: hydrogen atom, hydroxyl group, a protected hydroxyl group, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X  wherein X one of R hydrogen atom, amino group, hydroxyl group, a protected hydroxyl group, a group represented by the formula —OCON(R a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X or one of R a group represented by the formula —CH a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X or R oxo group, oxime group, a group represented by the formula ═N—X a group represented by the formula ═N—X a group represented by the formula ═N—X a group represented by the formula ═N—X  wherein X R hydrogen atom, a group represented by the formula —CONHCO a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X or R one of R hydrogen atom, hydroxyl group, a protected hydroxyl group, amino group, a protected amino group, a halogen atom, a group represented by the formula —OCONH a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X or may combine with R or R oxo group, oxime group, a group represented by the formula ═N—NH a protected oxime group, a group represented by the formula ═N—X a group represented by the formula ═N—X a group represented by the formula ═N—X a group represented by the formula ═N—X R hydrogen atom, hydroxyl group, a protective group of amino group, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X R hydrogen atom, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X R hydrogen atom, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X R hydrogen atom, a protective group of hydroxyl group, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X R hydrogen atom, a protective group of amino group, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X R hydrogen atom, hydroxyl group, a protected hydroxyl group, a group represented by the formula —X a group represented by the formula —X a group represented by the formula —X X a single bond a group represented by the formula —O—, a group represented by the formula —OCO—, a group represented by the formula —OCO a group represented by the formula —OCON(R a group represented by the formula —S(O) a group represented by the formula —SO a group represented by the formula —OCS—, a group represented by the formula —CO—, a group represented by the formula —CO a group represented by the formula —CON(R a group represented by the formula —CH═N—, a group represented by the formula —CH═N—O—, a group represented by the formula —CH═N(R a group represented by the formula —CH═N(R a group represented by the formula —CH═N(R a group represented by the formula —CH═N(OR a group represented by the formula —CH═N—N(R a group represented by the formula —CS—, a group represented by the formula —C(S)O—, a group represented by the formula —CSN(R a group represented by the formula —O—N═CH—, a group represented by the formula —N═CH—, a group represented by the formula —N(R a group represented by the formula —N(R a group represented by the formula —N(R a group represented by the formula —N(R a group represented by the formula —N(R a group represented by the formula —N(R A a divalent C an arylene group, or a divalent heterocyclic group, R a C a C a C a C a C an aryl group which may be substituted, or a heterocyclic group which may be substituted, substituents of the groups “which may be substituted” mentioned above each mean arbitrary 1 to 5 substituents selected from the following group of substituents, and the group of substituents consists of: carboxyl group, a halogen atom, oxo group, hydroxyl group, cyano group, nitro group, oxido group, sulfonic acid group, and thiol group, as well as the following group which may be substituted with groups of the group A: a C a C a C a C a C a C a C a carboxy(C a cyano(C a C a C an arylsulfonyl group which may be substituted with a C a C a C a (C a (C a C a C a C a (C a benzoyl group which may be substituted with 1 to 3 of halogen atoms or nitro groups, a C an aminosulfonyl group which may be substituted with 1 or 2 of C a C a C a benzenesulfonylamino group which may be substituted with C succinimido group, maleimido group, phthalimido group, a C a C tri-(C a group represented by the formula —N(R a group represented by the formula —CON(R a group represented by the formula —OCON(R a group represented by the formula —CH a group represented by the formula —O(CH “an aryl group, a heterocyclic group, an aryloxy group, an arylthio group, a heterocyclyloxy group or a heterocyclylthio group” which may be substituted with 1 to 5 of groups arbitrarily selected from the group consisting of “a C wherein group A consists of “an aryl group, a heterocyclic group, a heterocyclylthio group or an aryloxy group” which may be substituted with “a halogen atom, a C R p mentioned above is an integer of 0 to 2, n mentioned above is 1 or 2, and m mentioned above is an integer of 2 to 4}, or a pharmaceutically acceptable salt thereof.