Patent ID: 6187779
Filing Date: 2001-02-13
Classification: A61K

Abstract:
A method of treating a mammal having precancerous lesions comprising administering a pharmacologically effective amount of a compound of Formula I or pharmaceutically acceptable salt thereof: ##STR41##wherein A is an oxiranyl group, optionally substituted by straight-chain or branched alkyl with up to 8 carbon atoms, which in turn may be substituted by phenyl, or A is selected from the group consisting of ##STR42##wherein R.sup.1 is selected from the group consisting of hydrogen or a straight-chain or branched alkyl with up to 6 carbon atoms;R.sup.2 is selected from the group consisting of a straight-chain or branched alkyl with up to 8 carbon atoms, which is optionally substituted by phenyl;R.sup.3 is selected from the group consisting of a straight-chain or branched alkyl with up to 5 carbon atoms or a group with the formula --OR.sup.6,wherein R.sup.6 is selected from the group consisting of hydrogen, a hydroxy-protecting group, or a straight-chain or branched alkyl with up to 5 carbon atoms;R.sup.4 is selected from the group consisting of a straight-chain or branched alkyl with 2 to 10 carbon atoms, which is optionally substituted by phenyl;L is selected from the group consisting of --CO--, --CH(OH), --CH.sub.2, --CH(N.sub.3), or --CH(OSO.sub.2 R.sup.7);wherein R.sup.7 is selected from the group consisting of a straight-chain or branched alkyl with up to 4 carbon atoms or phenyl;R.sup.5 is selected from the group consisting of a straight-chain or branched alkyl with 3 to 8 carbon atoms, which is optionally substituted by phenyl, or benzyl or 2-phenylethyl;D is selected from the group consisting of hydrogen or a group with the formula --SO.sub.2 --NR 8R.sup.9 ;wherein R.sup.8 and R.sup.9 are the same or different and are selected from the group consisting of hydrogen, phenyl, or straight-chain or branched alkyl with up to 6 carbon atoms, which is optionally substituted by hydroxy, or R.sup.8 and R.sup.9 together with the nitrogen atom they form a 5- to 6-membered heterocyclic ring with up to 2 other hetero atoms selected from the group consisting of S, N, and/or O, which is optionally also substituted through a free N function by straight-chain or branched alkyl with up to 6 carbon atoms, which in turn may be substituted by hydroxy;E is a straight-chain or branched alkyl with up to 8 carbon atoms; and their tautomers and salts.