Patent ID: 6132987
Filing Date: 2000-10-17
Classification: A61K,A61P,C07K

Abstract:
An isolated polypeptide comprising the amino acid sequence of an MCP-1R polypeptide which is(a) a polypeptide having a sequence at least 90% identical to the sequence of MCP-1RA as shown in SEQ ID NO: 2,(b) a polypeptide having a sequence at least 90% identical to the sequence of MCP-1RB as shown in SEQ ID NO: 4, or(c) a fragment of a polypeptide according to (a) or (b) which binds specifically to MCP-1, wherein the sequence of the fragment is at least 90% identical to the corresponding portion of SEQ ID NO: 2 or SEQ ID NO: 4;wherein the MCP-1R polypeptide binds specifically to MCP-1 but not to MIP-1.alpha., MIP-1.beta., RANTES, or IL-8 under physiological conditions.