Patent ID: 7704987
Filing Date: 2010-04-27
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting the binding of one or more metal ions to a β-amyloid peptide in a patient in need thereof comprising exposing the peptide in said patient to a metal complex of a 1,10-phenanthroline said metal being Mn, Co, Ni, Cu, Ru, Pd, Ag, Cd, Pt, Au, Rh or Hg, wherein the metal complex binds to at least one histidine selected from the group of His 6, His 13 and His 4 of the N-terminal loop of the β-amyloid peptide, thereby blocking the binding of Cu 2+ , Zn 2+ and/or Fe 2+ ions to said at least one histidine residue.