Patent ID: 8188078
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. A compound of formula (Ia): Wherein: R represents a hydrogen atom, a halogen atom or an alkyl radical, A represents NH or S; R6 represents an aryl or heteroaryl radical optionally substituted with one or more radicals, which may be identical or different, selected from halogen atoms, hydroxyl, alkoxy, NR3R4 radicals, and alkyl, phenyl and phenylalkyl radicals, these last three radicals themselves are optionally substituted with one or more radicals selected from halogen atoms and hydroxyl, alkyl, alkoxy, NH2, NHalk and N(alk)2 radicals; and W represents a hydrogen atom or the radical COR7 in which R7 represents: wherein R3 and R4, identical or different, are such that one of R3 and R4 represents a hydrogen atom or an alkyl radical and the other of R3 and R4 represents a hydrogen atom, a cycloalkyl, CO2Alk radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, selected from hydroxyl, alkoxy, NH2, NHalk, N(alk)2 radicals and heteroaryl, heterocycloalkyl, and phenyl radicals optionally substituted with one or more radicals selected from halogen atoms and hydroxyl, alkyl and alkoxy radicals; or alternatively R3 and R4 form with the nitrogen atom to which they are attached a cyclic radical optionally containing one or more other heteroatoms selected from O, S, N and NH, said radical including the NH that it possibly contains are optionally substituted as indicated below; the heterocycloalkyl, heteroaryl, aryl and phenyl radicals defined above as well as the cyclic radicals that R1 and R2 or R3 and R4 can form with the nitrogen atom to which they are attached, are optionally substituted with one or more radicals selected from halogen atoms, hydroxyl, oxo, alkoxy, NH2, NHalk, N(alk)2, free or esterified carboxyl radicals and alkyl, cycloalkyl, heterocycloalkyl, phenyl, heteroaryl, (heterocycloalkyl)alkyl, (phenyl)alkyl, (heteroaryl)alkyl, —CO-heterocycloalkyl, —CO-phenyl, —CO-heteroaryl, —S-heterocycloalkyl, —S-aryl, —S-heteroaryl, —O-heterocycloalkyl, —O-aryl and —O-heteroaryl radicals, such that in these last-mentioned radicals, the heterocycloalkyl, phenyl and heteroaryl radicals are themselves optionally substituted with one or more radicals selected from halogen atoms and hydroxyl, oxo, alkyl and alkoxy radicals containing from 1 to 4 carbon atoms, NH2, NHalk and N(alk)2; and wherein: -R6 bears at least one halogen atom; -R7 does not represent a methoxy radical; or an addition salt thereof with a mineral or organic acid or with a mineral or organic base.