Patent ID: 6271217
Filing Date: 2001-08-07
Classification: A61K,A61P

Abstract:
A method of treating cancer susceptible to treatment in a warm blooded mammal comprising:administering to the mammal a safe and effective amount of a cyclophosphamide to reduce the cancer significantly; andadministering to the mammal a pharmaceutical composition comprising an enhanced safe and effective amount of a benzimidazole of the formula: ##STR5##wherein:X is hydrogen, halogen, alkyl of less than 7 carbon atoms, or alkoxy of less than 7 carbon atoms;n is a positive integer of less than 4;Y is hydrogen, chloro, nitro, methyl, or ethyl;R is hydrogen, an alkyl group of from 1 to 8 carbon atoms, or CONHR.sub.3 wherein R.sub.3 is alkyl of less than 7 carbons; andR.sub.2 is 4-thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is an aliphatic hydrocarbon of less than 7 carbon atoms.