Patent ID: 8501800
Filing Date: 2013-08-06
Classification: A61K,A61P

Abstract:
1. An ophthalmically acceptable drug delivery vehicle, comprising: an aqueous suspension having a first viscosity, said suspension comprising from about 0.1% to about 6.5% by weight, based on the total weight of the suspension, of a polycarbophil prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent, said weight percentages of monomers being based on the total weight of monomers polymerized, said polycarbophil having average particle size of not more than about 50 μm in equivalent spherical diameter, and no more than 5% of said polycarbophil has a particle size below 1 μm, and; a sufficient amount of chitosan to allow said polycarbophil to remain suspended, wherein upon contact with tear fluid, said vehicle gels to a second viscosity which is greater than the first viscosity.