Patent ID: 7994119
Filing Date: 2011-08-09
Classification: A61K,A61P

Abstract:
1. A method for controlling an NPY mediated physiological response in a subject comprising administering to said subject a compound having the formula: wherein: R8 is H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-(SEQ. ID. NO.1), H-[X(Y)]  (SEQ. ID. NO. 9), Ac-Arg-Tyr-Arg-Gly-Asp-Leu-Gly-Leu-Gly-Arg-Arg (SEQ. ID. NO. 10), or  SEQ. ID. NO. 11); A1 is a D or L-amino acid selected from Cys, Leu, Dap, Trp, Gln, a tethered amino acid with an indole ring, Phe, Hyp, a Trp derivative; C Linker is a compound that forms a peptide bond with A1 and forms one of either a peptide or ester bond with R8; A2 is a D or L-amino acid selected from Gly, Cys, Trp, Arg, N-Me-Arg, C A3 is a D or L-amino acid selected from Glu, Tyr, N-Me-Tyr, C n=1, 2 or 3 W is —OH, —N-R3R4, or OR5 where R3, R4, and R5, independently, is H, C1-C12 alkyl, C6-C18 aryl, C1-C12 acyl, C7-C18 aralkyl, or C7-C18 alkaryl; or a pharmaceutically acceptable salt thereof; and each bond between two amino acids or amino acid derivatives, represented by a dash (“-”), can be either a peptide bond or a pseudopeptide bond; or a pharmaceutically acceptable salt thereof.