Patent ID: 6046034
Filing Date: 2000-04-04
Classification: A61K,C07K

Abstract:
A substituted interferon-gamma (IFN-.gamma.) protein comprising:(a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 whereinXaa at position 8 is Glu or Cys,Xaa at position 70 is Ser or Cys,Xaa at position 18 is Ala or Cys,Xaa at position 112 is His or Cys,Xaa at position 81 is Lys or Cys,Xaa at position 121 is Leu or Cys,Xaa at position 49 is Gln or Cys, andXaa at position 96 is Leu or Cys,wherein Cys residues are present at both positions of at least one pair selected from the group consisting of positions 8 and 70, 18 and 112, 81 and 121, and 49 and 96;(b) a polypeptide which differs from a polypeptide according to (a) by the deletion of 1 to 10 amino acids from the C-terminus; or(c) a homodimer of a polypeptide according to (a) or (b).