Patent ID: 6250298
Filing Date: 2001-06-26
Classification: A61J,A61K,A61M

Abstract:
A method of improving reproducibility of a drug delivered via lungs by inhalation, comprising:(a) aerosolizing a formulation comprising a pharmaceutically active drug;(b) inhaling the aerosolized formulation into the lungs of a patient, the formulation being inhaled with a first total inhaled volume;(c) allowing particles of formulation to settle in the lungs, migrate into the patient's circulatory system and thereby increase the concentration of the drug to a first maximum level in the patient's blood in a first period of time;(d) repeating the aerosolizing of formulation comprised of pharmaceutically active drug;(e) inhaling the aerosolized formulation of (d) into the lungs of a patient, the formulation being inhaled with a second total inhaled volume different from the first total inhaled volume;(f) allowing particles of formulation to settle in the lungs, migrate into the patient's circulatory system and thereby increase the concentration of the drug to a second maximum level in the patient's blood in a second period of time;whereby the difference between the first total inhaled volume and the second total inhaled volume does not substantially effect the difference between the first maximum level of drug and the second maximum level of drug.