Patent ID: 6407123
Filing Date: 2002-06-18
Classification: C07D

Abstract:
A compound of the formula whereinR1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl, halogen, â€”CN, â€”NO2, â€”CO2R6, â€”COR6, â€”OR6, â€”SR6, â€”SOR6, â€”SO2R6, â€”CONR7R8, â€”NR6N(R7R8), â€”N(R7R8) or Wâ€”Yâ€”(CH2)nâ€”Z; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, or aryl; A is a six membered ring containing one nitrogen; W is O, NR6, or is absent; Y is â€”(CO)â€” or â€”(CO2)â€”, or is absent; Z is alkyl of 1 to 4 carbon atoms, â€”CN, â€”CO2R6, COR6, â€”CONR7R8, â€”OCOR6, â€”NR6COR7, â€”OCONR6, â€”OR6, â€”SR6, â€”SOR6, â€”SO2R6, SR6N(R7R8), â€”N(R7R8) or phenyl; G is a five membered ring containing an oxygen, sulfur, or nitrogen; X is a bond, and n is an integer from 1 to 6; or a pharmaceutical salt thereof.