Patent ID: 6203788
Filing Date: 2001-03-20
Classification: A61K,C07K

Abstract:
A method for treating a demyelinating neurological disease in a mammal, comprising implanting in a mammal:(a) a cell adhesion modulating agent that is 6-50 amino acid residues in length, wherein said modulating agent comprises the sequence His-Ala-Val and at least one flanking amino acid residue present within an endogenous N-cadherin sequence selected from the group consisting of SEQ ID NOs:3-5, and wherein said modulating agent inhibits N-cadherin-mediated cell adhesion; and(b) one or more cells selected from the group consisting of Schwann cells and oligodendrocyte progenitor cells from individuals not affected with a demyelinating disease;wherein said modulating agent and said cell(s) are implanted into the mammal's central nervous system in an amount sufficient to inhibit N-cadherin-mediated cell adhesion, thereby facilitating said cell(s) migration and treating a demyelinating neurological disease.