Patent ID: 6756384
Filing Date: 2004-06-29
Classification: C07D

Abstract:
A compound of the formula (Ih): whereinq is 1, 2 or 3, Z is selected from C1-6-alkyl, C2-6-alkenyl, aryl, aryloxy, heteroaryl, C3-10-cycloalkyl, C3-8-heterocyclyl and aryl annulated with C3-8-heterocyclyl, which are unsubstituted or substituted with one or more substituents selected fromnitro, â€”NR12R13, â€”S(&boxH;O)2NR12R13, â€”C(&boxH;O)NR12R13, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C1-6-alkyl substituted with hydroxy, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy substituted with hydroxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR12, C1-6-alkylcarbonyl, â€”C(&boxH;NOR12)C1-6-alkyl, C3-10-cycloalkyl, C3-10cycloalkylcarbonyl, â€”C(&boxH;NOR12) C3-10-cycloalkyl, aryl-C1-6-alkyl, heteroarylâ€”C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, â€”C(&boxH;NOR12)aryl, â€”C(&boxH;NOR12)heteroaryl, arylthio, heteroarylthio and heteroaryloxy, wherein R12 and R13 independently are hydrogen or C1-6-alkyl, aryl and aryloxy, which are optionally substituted with one or more substituents selected from C1-6-alkyl, C1-6-alkoxy, halogen, â€”OCF3 or â€”CF3, C1-6-alkyl, C2-6-alkenyl, or C2-6-alkynyl, which are unsubstituted or substituted with one or more substituents selected fromheteroaryl, aryl, aryloxy, aroyl, C3-10-cycloalkyl, C3-8-heterocyclyl and aryl annulated with C3-8-heterocyclyl, which are optionally substituted with one or more substituents selected from nitro, â€”NR12R13, â€”S(&boxH;O)2NR12R13, â€”C(&boxH;O)NR12R13, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C1-6-alkyl substituted with hydroxy, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy substituted with hydroxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR12, C1-6-alkylcarbonyl, â€”C(&boxH;NOR12)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, &boxH;C(&boxH;NOR12)C3-10cycloalkyl, aryl-C1-6-alkyl, heteroaryl-C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, â€”C(&boxH;NOR12)aryl, â€”C(&boxH;NOR12)heteroaryl, arylthio, heteroarylthio and heteroaryloxy, wherein R12 and R13 independently are hydrogen or C1-6-alkyl, aryl and aryloxy, which are optionally substituted with one or more substituents selected from C1-6-alkyl, C1-6-alkoxy, halogen, â€”OCF3 or â€”CF3, and R1 is hydrogen or a group which can be converted to hydrogen in vivo,R2 is hydrogen,R3 and R4 independently are hydrogen or C1-6-alkyl, which is unsubstituted or substituted with aryl or heteroaryl, which are unsubstituted or substituted with one or more substituents selected from nitro, â€”NR7R8, â€”S(&boxH;O)2NR7R8, â€”C(&boxH;O)NR7R8, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR7, C1-6-alkylcarbonyl, â€”C(&boxH;NOR7)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, â€”C(&boxH;NOR7)C3-10-cycloalkyl, aryl-C1-6-alkyl, heteroarylâ€”C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, â€”C(&boxH;NOR7)aryl, â€”C(&boxH;NOR7)-heteroaryl, arylthio, heteroarylthio, aryloxy and heteroaryloxy, wherein R7 and R8 independently are hydrogen or C1-6-alkyl,and R11 is hydrogen or C1-6alkyl, orq is 0, Z is C3-8-cycloalkyl or C3-8heterocyclyl, which is unsubstituted or substituted with one or more substituents selected fromnitro, â€”NR12R13, â€”S(&boxH;O)2NR12R13, â€”C(&boxH;O)NR12R13, hydroxy, halogen, cyano, trifluoromethyl, â€”OCF3, â€”OCHF2, â€”OCH2CHF2, C1-6-alkyl, C1-6-alkyl substituted with hydroxy, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6alkoxy substituted with hydroxy, C1-6-alkylthio, C1-6-alkylsulfonyl, â€”C(&boxH;O)OR12, C1-6-alkylcarbonyl, â€”C(&boxH;NOR12)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, â€”C(&boxH;NOR12) C3-10cycloalkyl, aryl-C1-6-alkyl, heteroaryl-C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, â€”C(&boxH;NOR12)aryl, â€”C(&boxH;NOR12)heteroaryl, arylthio, heteroarylthio and heteroaryloxy, wherein R12 and R13 independently are hydrogen or C1-6-alkyl, aryl and aryloxy, which are optionally substituted with one or more substituents selected from C1-6-alkyl, C1-6-alkoxy, halogen, â€”OCF3 or â€”CF3, and R1, R2, R3, R4 and R11 are as defined above,or any optical or geometric isomer or tautomeric form thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof.