Patent ID: 8999317
Filing Date: 2015-04-07
Classification: A61L,A61P,C07K,C12N,C12Q,C12Y,G01N

Abstract:
1. A method of inhibiting viral infectivity in a cell comprising administering an inhibitor of the interaction between low molecular mass APOBEC3 G (LMM) dimers and high molecular mass APOBEC3G (HMM) conversion molecules to the cell, wherein the inhibitor stabilizes the LMM dimer, thereby inhibiting viral infectivity in the cell, wherein the inhibitor is selected from the group consisting of a small molecule, a peptide, a nucleic acid molecule, an antibody, and any combinations thereof, and wherein the inhibitor binds to at least one domain selected from the group consisting of the N-terminal pseudocatalytic domain and C-terminal pseudocatalytic domain of LMM.