Patent ID: 8440712
Filing Date: 2013-05-14
Classification: A61P,C07D

Abstract:
1. A pharmaceutical composition comprising crystalline sodium atorvastatin and a diluent or excipient, wherein the crystalline sodium atorvastatin is prepared by a method comprising: (a) adding amorphous sodium atorvastatin to a first organic solvent to form a first solution; (b) adding a second organic solvent to the first solution to form a second solution; (c) allowing sodium atorvastatin to crystallize out from the solution; and (d) collecting the crystallized sodium atorvastatin, wherein the first organic solvent is ethanol and wherein the second organic solvent is butanone thereby obtaining crystalline sodium atorvastatin which exhibits an X-ray diffraction pattern comprising peaks expressed in degrees two-theta at approximately 3.67±0.2, 5.05±0.2, 6.85±0.2, 7.18±0.2, 8.33±0.2, 8.62±0.2, 9.38±0.2, 10.02±0.2, 10.35±0.2, 10.71±0.2, 11.76±0.2, 12.66±0.2, 13.87±0.2, 16.01±0.2, 16.38±0.2, 17.1±0.2, 19.1±0.2, 19.42±0.2, 20.88±0.2, 21.16±0.2, 22.9±0.2, 23.6±0.2, 30.12±0.2, 33.12±0.2, 37.92±0.2 and 41.47±0.2.