Patent ID: 6642203
Filing Date: 2003-11-04
Classification: A61K,A61P,C07K

Abstract:
A purified antimicrobial peptide obtained from penaeid prawns with a molecular mass of about 5 to 7 kDa and an isoelectric pH greater than or equal to 9; said peptide comprising:a) a N-terminal region (A) of about 15 to 25 amino acids, which comprises the following motif (I): ProXaa1 ProXaa2 ProXaa3 Pro(SEQ ID NO:15 or 19) in which Xaa1 is a nonpolar neutral amino acid, Xaa2 is a basic amino acid and Xaa3 is a proline or a peptide bond; andb) a C-terminal region (B) of about 20 to 30 amino acids, which contains 6 cysteine residues forming three intramolecular disulfide bridges and arranged according to the following motif (IV): Cys S1 Cys S2 Cys Cys S3 Cys Cys (SEQ ID NO: 16 or 20) in which S1 is an amino acid or a peptide sequence of 2 or 3 amino acids, S2 is a peptide sequence of 10 amino acids, and S3 is a peptide sequence of 5 amino acids.