Patent ID: 6506701
Filing Date: 2003-01-14
Classification: B01J,C07B,C07C,C07D,C08F,C08G,C40B,Y10S

Abstract:
A method for enhancing the purity of a solid compound which comprises:step (a) treating a crude reaction product which contains the solid compound, unreacted starting materials and/or byproducts with at least one polymer-supported quenching reagent of Formula I, Pâ€”Lâ€”Qâ€ƒâ€ƒI â€ƒwherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is selected from the group consisting of NHCH2CH2N(CH2CH2NH2)2, O(CH2)3CHO, O-(3-formylpheny), NHC(&boxH;S)NH2, NHCH2CH2SH, 1-thiomorpholine, and 1-maleimide; L is a group between P and Q selected from the group consisting of CH2â€”N, â€”CH2â€” and â€”CH2â€”CH2â€”O; step (b) allowing the polymer-supported quenching reagent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized reagent of Formula II, â€ƒPâ€”Lâ€”Qâ€”Xâ€ƒâ€ƒIIâ€ƒwherein X is unreacted starting material and/or byproduct and P, L, and Q are as defined above; and step (c) separating the reagents of Formula I and Formula II from the solution and removing solvent to afford a solid compound of enhanced purity.