Patent ID: 6255494
Filing Date: 2001-07-03
Classification: A61K,C07D

Abstract:
A compound of the formula ##STR443##wherein:R.sup.1 is phenoxy(C.sub.1 -C.sub.6 alkylenyl)-,of which phenoxy moieties may be substituted with one or more groups selected from the group consisting of halo, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, nitro, amino, t-butoxycarbonylamino, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylamino, heterocyclic, unsaturated heterocyclic, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, phenyl, phenoxy, phenyl(C.sub.1 -C.sub.6 alkylenyl)-, phenyl(C.sub.1 -C.sub.6 alkoxy)-, benzoyl, phenyl(C.sub.2 -C.sub.7 alkanoyl)-, and phenyl(C.sub.2 -C.sub.7 alkanoyloxy)-;R.sup.2 is C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.2 -C.sub.7 alkanoyl, C.sub.1 -C.sub.6 alkoxy, heterocyclic(C.sub.2 -C.sub.6 alkylenyl)-, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, unsaturated heterocyclic(C.sub.2 -C.sub.6 alkylenyl)-, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, phenyl, phenyl(C.sub.1 -C.sub.6 alkylenyl)-, naphthyl, naphthyl(C.sub.1 -C.sub.6 alkylenyl)-, phenoxy(C.sub.1 -C.sub.6 alkylenyl)-, naphthyloxy(C.sub.1 -C.sub.6 alkylenyl)-, benzoyl(C.sub.1 -C.sub.6 alkylenyl)-, C.sub.2 -C.sub.7 carbamoyl, C.sub.2 -C.sub.7 amido, C.sub.1 -C.sub.6 alkoxycarbonyl-, or C.sub.1 -C.sub.6 haloalkyl,any one of which phenyl, naphthyl, phenoxy, naphthyloxy, benzoyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, heterocyclic, or unsaturated heterocyclic moieties may be substituted with one or more groups selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, phenyl, naphthyl, phenyl(C.sub.1 -C.sub.6 alkylenyl)-, naphthyl(C.sub.1 -C.sub.6 alkylenyl)-, halo, trifluoromethyl, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, heterocyclic, unsaturated heterocyclic, heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, C.sub.2 -C.sub.7 alkanoyl, C.sub.2 -C.sub.7 alkanoyloxy, C.sub.1 -C.sub.6 alkylamino, dimethylamino, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 haloalkyl, amino, nitro, and hydroxy,or R.sup.2 may also be --(CH.sub.2).sub.n --NR.sup.7 R.sup.8, where,n is 2 to 10, andR.sup.7 and R.sup.8 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkanoyl, C.sub.1 -C.sub.6 alkoxy, heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, phenyl, phenyl(C.sub.1 -C.sub.6 alkylenyl)-, naphthyl, naphthyl(C.sub.1 -C.sub.6 alkylenyl)-, phenoxy(C.sub.1 -C.sub.6 alkylenyl)-, naphthyloxy(C.sub.1 -C.sub.6 alkylenyl)-, benzoyl(C.sub.1 -C.sub.6 alkylenyl)-, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, C.sub.1 -C.sub.6 haloalkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.3 -C.sub.8 cycloalkenyl, or C.sub.3 -C.sub.8 cycloalkyl,any one of which phenyl, naphthyl, phenoxy, naphthyloxy, C.sub.3 -C.sub.8 cycloalkyl, benzoyl, heterocyclic, unsaturated heterocyclic, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, or unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)- moieties may be substituted with one or more groups selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, trifluoromethyl, alkoxy, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, heterocyclic, unsaturated heterocyclic, heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, C.sub.2 -C.sub.7 alkanoyl, C.sub.2 -C.sub.7 alkanoyloxy, C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.6 alkylthio, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.1 -C.sub.6 haloalkyl, amino, nitro, and hydroxy;andR.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkynyl, C.sub.2 -C.sub.7 alkanoyl, C.sub.2 -C.sub.7 alkanoyloxy, C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.6 alkylthio, benzoyl, phenoxy, phenyl(C.sub.1 -C.sub.6 alkylenyl)-, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl, phenyl(C.sub.1 -C.sub.6 alkoxy)-, phenyl(C.sub.1 -C.sub.6 alkyleneamino)-, phenyl(C.sub.1 -C.sub.6 alkyleneamino)-, phenyl(C.sub.2 -C.sub.7 alkanoyl)-, phenyl(C.sub.2 -C.sub.7 alkanoyloxy)-, heterocyclic, unsaturated heterocyclic, heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkylenyl)-, unsaturated heterocyclic(C.sub.1 -C.sub.6 alkoxy)-, amino, nitro, hydroxy, trifluoromethyl, or --(CH.sub.2).sub.n --NR.sup.7 R.sup.8 ;or a salt or solvate thereof.