Patent ID: 6114151
Filing Date: 2000-09-05
Classification: C12Q

Abstract:
A method for diagnosing an individual as having atopy or a predisposition thereto, which comprises demonstrating in the individual the presence or absence of either: (i) a variant form of the gene which codes for the beta sub-unit of the high affinity receptor for IgE (Fc.epsilon.RI.beta.), the variant form comprising a variation in exon 7 which encodes a glycine at amino acid residue 237 instead of glutamic acid which appears at residue 237 in individuals without atopy; or (ii) a polymorphic form of the amino acid sequence for Fc.epsilon.RI.beta., the polymorphic form comprising glycine at amino acid residue 237 instead of glutamic acid which appears at residue 237 in individuals without atopy.