Patent ID: 6780858
Filing Date: 2004-08-24
Classification: A61P,C07C,C07D

Abstract:
A compound having the formula: and pharmaceutically acceptable salts thereof; wherein R18 is selected from the group consisting of (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, (C1-C4)haloalkyl, (C1-C4)haloalkoxy and halogen; B is a phenyl group optionally substituted with one to three substituents selected from the group consisting of halogen (C1-C4)haloalkyl, (C1-C4)haloalkoxy, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, phenyl, phenoxy and â€”CO2Me; R16 and R17 are independently selected from the group consisting of hydrogen, (C1-C8)alkyl and (C1-C8)heteroalkyl; or R16 and R17 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring optionally having additional heteroatoms as ring members and optionally substituted with substituted with substituents selected from the group consisting of (C1-C8)alkyl, (C1-C8)heteroalkyl, hydroxyl, amino, acetoamido and phenyl.