Patent ID: 7179833
Filing Date: 2007-02-20
Classification: A61K,A61P,C07D,C07K

Abstract:
1. A process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof, wherein a compound of formula (II): is reacted with a compound of formula (III): wherein R 1 represents imidazolyl, benzimidazolyl or tetrazolyl, to yield a compound of formula (IV): which is reacted with a compound of formula (V): wherein R 2 represents hydrogen, benzyl or linear or branched (C 1 –C 6 )alkyl, or an addition salt thereof with a mineral or organic acid, to yield, after isolation, a compound of formula (VI): which is hydrogenated in the presence of a catalyst, under a hydrogen pressure of from 1 to 30 bars, to yield, after deprotection of the acid function where necessary, perindopril of formula (I), which is converted, if desired, into a pharmaceutically acceptable salt.