Patent ID: 8859216
Filing Date: 2014-10-14
Classification: G01N

Abstract:
1. A method for prediction or diagnosis of intra-amniotic inflammation or infection in a pregnant female subject comprising: 1) measuring in a sample of amniotic fluid leaked through the cervix into the vagina in the subject the concentration of one or more inflammatory marker(s) selected from the group consisting of interleukin-6 (IL-6), IL-1β, IL-8, monocyte chemoattractant protein-1 (MCP-1), and GRO-α (Growth Related Oncogene-α); and 2) predicting or diagnosing the risk for inflammation or infection in the subject if the concentration of IL-6 measured is higher than a cut-off value of 1 to 10 ng/ml, the concentration of IL-1β measured is higher than a cut-off value of 100 to 1000 pg/ml, the concentration of IL-8 measured is higher than a cut-off value of 1 to 30 ng/ml, the concentration of MCP-1 measured is higher than a cut-off value of 500 to 2500 pg/ml, or the concentration of GRO-α measured is higher than a cut-off value of 500 to 5000 pg/ml.