Patent ID: 6579976
Filing Date: 2003-06-17
Classification: C07H

Abstract:
A process for producing a nucleoside derivative represented by the formula (II): wherein B represents a nucleic acid base residue or a derivative thereof, R represents a hydrogen atom or a hydroxy group-protecting group, and one of Yâ€² and Xâ€² represents a hydrogen atom and the other represents a hydrogen atom, a fluorine atom, a hydroxyl group or a protected hydroxyl group, respectively, which comprises allowing a nucleoside derivative represented by the formula (I): wherein B and R have the same meanings as defined above, and one of Y and X represents a leaving group and the other represents a hydrogen atom, a fluorine atom, a hydroxyl group or a protected hydroxyl group, respectively, to react with at least one compound selected from hypophosphorous acids, or salts thereof and esters of phosphorous acid in the presence of a radical reaction initiator.