Patent ID: 7846951
Filing Date: 2010-12-07
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating cystic fibrosis, hereditary emphysema, or COPD, comprising administering to a patient a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein X is O or S; R Z is a bond or is an optionally substituted C each occurrence of R is independently hydrogen or an optionally substituted C R R wherein m, and q are each independently 0 or 1, p is 1, and U and V are each independently an optionally substituted C 1-4 alkylidene chain, wherein up to two methylene units of the chain are optionally and independently replaced by —CO—, —CO 2 —, —COCO—, —CONR—, —OCONR—, —NRNR—, —NRNRCO—, —NRCO—, —NRCO 2 —, —NRCONR—, —SO—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, —NRSO 2 NR—, —O—, —S—; or —NR—; T is an optionally substituted C Cy R wherein r is 0, 1, or 2; one of X 3 , X 4 , or X 5 is CH—V p -Cy 1 or N—V p -Cy 1 , and the others of X 3 , X 4 , or X 5 is CHR′ or NR′; and each occurrence of X 1 , when present, and X 2 are each independently C(R′) 2 , —CO—, or —CS—.