Patent ID: 7176296
Filing Date: 2007-02-13
Classification: A61K

Abstract:
1. A compound having increased or reduced immunostimulatory effect, the compound comprising a 5′-CpG-3′ dinucleotide, wherein C is cytosine and G is guanosine or a substituted guanosine, and an immunomodulatory moiety, wherein the immunomodulatory moiety is selected from the group consisting of abasic nucleoside, 1,3-propanediol linker, nitropyrrole, nitroindole, deoxyuridine, inosine, isoguanosine, 2-aminopurine, nebularine, 7-deazaguanosine, 4-thiodeoxyuridine, 4-thiothymidine, d-isoguanosine, d-iso-5-methylcytosine, P-base, and 3′-3′ linkage, wherein the compound is 12 to 35 nucleotides in length, wherein the compound does not have antisense activity, and wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the immunomodulatory moiety.