Patent ID: 6825360
Filing Date: 2004-11-30
Classification: A61K,A61P,A61Q,C07C,C07D

Abstract:
A bicyclic aromatic compound, having the general formula (I): wherein,R1 represents: (i) the â€”CH3 radical; (ii) the radical â€”CH2OR5; or (iii) the radical â€”COR6; Ar is a radical of the formula (c) or (d): X represents â€ƒor R2 and R3, which may be identical or different, represent (i) a hydrogen atom; (ii) an alkyl radical having at least 3 carbon atoms, among which the carbon attached to the phenyl radical is substituted with at least two carbon atoms; (iii) a radical â€”OR5; (iv) a radical â€”SR5; or R2 and R3, taken together, form with the adjacent aromatic ring a 5- or 6-membered ring optionally substituted with methyl groups and/or optionally interrupted by an oxygen or sulphur atom, with the proviso that: R2 and R3 cannot both be hydrogen; R2 and R3 cannot both be a radical â€”OR5; R2 and R3 cannot both be a radical â€”SR5; when R2 is hydrogen, R3 cannot be a radical â€”OR5 or a radical â€”SR5; when R2 is a radical â€”OR5, R3 cannot be hydrogen or a radical â€”SR5; when R2 is a radical â€”SR5, R3 cannot be a radical â€”OR5 or hydrogen; when R3 is hydrogen, R2 cannot be a radical â€”OR5 or a radical â€”SR5; when R3 is a radical â€”OR5, R2 cannot be hydrogen or a radical â€”SR5; when R3 is a radical â€”SR5, R2 cannot be a radical â€”OR5 or hydrogen; R4 and R7, which may be identical or different, represent a hydrogen atom, a halogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms or a radical â€”OR5, R5 represents a hydrogen atom, a lower alkyl radical or a radical â€”COR10 R6 represents: (a) a hydrogen atom; (b) a lower alkyl radical; (c) a radical of formula: or (d) a radical â€”OR11 R8 and R9, which may be identical or different, represent a hydrogen atom or a lower alkyl radical, R10 represents a lower alkyl radical, R11 represents a hydrogen atom, a linear or branched alkyl radical having from 1 to 20 carbon atoms, and alkenyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical, a sugar residue or an amino acid or peptide residue, Râ€² and Râ€³, which may be identical or different, represent a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid or sugar residue, or alternatively, taken together form a heterocycle, a salt thereof or an optical or geometrical isomer thereof.