Patent ID: 6720308
Filing Date: 2004-04-13
Classification: A61K,A61P,C07H

Abstract:
A compound represented by the formula and the pharmaceutically acceptable salts, esters and prodrugs thereof, whereinL is selected from the group consisting of: (1) â€”CH(OH)CH3; (2) C1-C6 alkyl, optionally substituted with one or more substituents selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; (3) C2-C6 alkenyl, optionally substituted with one or more substituents selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; and (4) C2-C6 alkynyl, optionally substituted with one or more substituents selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R1 is selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl, each optionally substituted with one or more substituents selected from the group consisting of: (1) halogen; (2) aryl; (3) substituted aryl; (4) heteroaryl; (5) substituted heteroaryl; (6) â€”Oâ€”R5, where R5 is selected from the group consisting of: a. hydrogen; b. aryl; c. substituted aryl; d. heteroaryl; and e. substituted heteroaryl; (7) â€”Oâ€”C1-C6-alkyl-R5; (8) â€”Oâ€”C2-C6-alkenyl-R5; (9) â€”Oâ€”C2-C6-alkynyl-R5; and (10) â€”NR6R7, where R6 and R7 are each independently selected from the group consisting of: hydrogen; C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic; C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic; and C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic; or R6R7 taken together with the nitrogen atom to which they are connected form a 3- to 7-membered ring which may optionally contain one or more hetero functions selected from the group consisting of â€”Oâ€”, â€”NHâ€”, â€”N(C1-C6-alkyl)-, â€”N(aryl)-, â€”N(heteroaryl)-, â€”Sâ€”, â€”S(O)â€” and â€”S(O)2â€”; R2 is selected from the group consisting of: (1) hydrogen; (2) C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of: a. halogen; b. aryl; c. substituted aryl; d. heterocyclic; e. substituted heterocyclic; f. â€”Oâ€”R3, where R3 is selected from the group consisting of: i. hydrogen; ii. aryl; iii. substituted aryl; iv. heteroaryl; and v. substituted heteroaryl; g. â€”Oâ€”C1-C6-alkyl-R3; h. â€”Oâ€”C2-C6-alkenyl-R3; i. â€”Oâ€”C2-C6-alkynyl-R3; and j. â€”NR6R7; (3) C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of: a. halogen; b. aryl; c. substituted aryl; d. heterocyclic; e. substituted heterocyclic; f. â€”Oâ€”R3; g. â€”Oâ€”C1-C6-alkyl-R3; h. â€”Oâ€”C2-C6-alkenyl-R3; i. â€”Oâ€”C2-C6-alkynyl-R3; and j. â€”NR6R7; and (4) C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of: a. halogen; b. aryl; c. substituted aryl; d. heterocyclic; e. substituted heterocyclic; f. â€”Oâ€”R3; g. â€”Oâ€”C1-C6-alkyl-R3; h. â€”Oâ€”C2-C6-alkenyl-R3; i. â€”Oâ€”C2-C6-alkynyl-R3; and j. â€”NR6R7; X is selected from the group consisting of: (a) S(O)n, where n is 0, 1, or 2; (b) O; and (c) NR5; and Rp is hydrogen or a hydroxy protecting group.