Patent ID: 6617324
Filing Date: 2003-09-09
Classification: A61P,C07D

Abstract:
A compound, a tautomer of the compound, or a pharmaceutically-acceptable salt of the compound or tautomer, wherein:the compound corresponds in structure to the following formula: as to R1:R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkylalkyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, arylalkyl, arylalkenyl, arylalkynyl, carboxy, carboxyalkyl, alkoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl, aryloxyalkyl, alkoxyalkoxy, mercaptoalkyl, alkylthioalkyl, alkenylthioalkyl, alkylthioalkenyl, amino, aminoalkyl, alkylamino, alkenylamino, alkynylamino, arylamino, alkylsulfinyl, alkenylsulfinyl, alkynylsulfinyl, arylsulfinyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, arylsulfonyl, alkylaminoalkyl, alkylsulfonylalkyl, acyl, acyloxycarbonyl, alkoxycarbonylalkyl, aryloxycarbonylalkyl, alkoxycarbonylaryl, aryloxycarbonylaryl, alkylcarbonylalkyl, arylcarbonylalkyl, alkylcarbonylaryl, arylcarbonylaryl, alkylcarbonyloxyalkyl, arylcarbonyloxyalkyl, alkylcarbonyloxyaryl, and arylcarbonyloxyaryl, or R1 corresponds in structure to the following formula: i is an integer from zero to 9; and R25 is selected from the group consisting of hydrogen, alkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, alkylaminoalkyl, arylaminoalkyl, alkylcarbonylalkyl, and arylcarbonylalkyl; and R26 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkylalkyl, arylalkyl, alkoxycarbonylalkyl, and alkylaminoalkyl; and as to R27;R27 is selected from the group consisting of alkyl, cycloalkyl, alkynyl, aryl, arylalkyl, cycloalkylalkyl, cycloalkenylalkyl, cycloalkylaryl, cycloalkylcycloalkyl, alkylaryl, alkylarylalkyl, arylalkylaryl, alkoxyalkyl, alkoxyaryl, alkoxyarylalkyl, alkoxyalkoxyaryl, aryloxyaryl, arylalkoxyaryl, aryloxyalkoxyaryl, alkoxycarbonylalkyl, aminoalkyl, alkylaminoalkyl, arylaminocarbonylalkyl, alkoxyarylaminocarbonylalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, alkylaminocarbonylalkyl, arylcarbonylalkyl, alkoxycarbonylaryl, aryloxycarbonylaryl, alkylaryloxycarbonylaryl, arylcarbonylaryl, alkylarylcarbonylaryl, alkoxycarbonylalkoxylaryl, alkylthioalkyl, cycloalkylthioalkyl, alkylthioaryl, arylalkylthioaryl, arylthioalkylaryl, arylsulfonylaminoalkyl, alkylsulfonylaryl, and alkylaminosulfonylaryl, wherein: the alkyl, cycloalkyl, arylalkyl, alkoxyaryl, aryloxyaryl, arylaminocarbonylalkyl, aryloxycarbonylaryl, arylcarbonylaryl, alkylthioaryl, arylthioalkylaryl, or alkylsulfonylaryl may be optionally substituted with one or more substituents independently selected from the group consisting of alkyl, halo, haloalkyl, alkoxy, keto, amino, nitro, and cyano, or R27 is â€”CHR28R29; and R28 is alkoxycarbonyl; and R29 is selected from the group consisting of arylalkyl, arylalkoxyalkyl, alkoxycarbonylalkyl, alkylthioalkyl, and arylalkylthioalkyl, wherein: the arylalkyl may be optionally substituted with one or more substituents independently selected from the group consisting of alkyl and nitro; and R2 is â€”R200-cyclohexyl, wherein: the cyclohexyl may be optionally substituted with one or more substituents independently selected from the group consisting of halo, keto, amino, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, arylalkyl, heterocyclylalkyl, epoxyalkyl, amino(hydroxyalkyl) carboxy, alkoxy, aryloxy, arylalkoxy, haloalkyl, alkylamino, alkynylamino, alkylaminoalkylamino, heterocyclylalkylamino, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, arylsulfonyl, and arylalkylsulfonyl; and R200 is selected from the group consisting of: â€”(C(R200)(R203))yâ€”, â€”N(R202)â€”, Sâ€”, â€”Oâ€”, and a bond; and R202 and R203 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, phenyl, and benzyl; and R3 is selected from the group consisting of pyridinyl and pyrimidyl, wherein: the pyridinyl or pyrimidyl may be optionally substituted with one or more substituents independently selected from the group consisting of halo, alkyl, arylalkyl, arylalkenyl, haloarylalkyl, haloarylalkenyl, haloarylalkylamino, carboxy, carboxyalkyl, alkoxy, aryloxy, alkylthio, arylthio, arylsulfinyl, arylsulfonyl, arylalkoxy, amino, alkylamino, alkenylamino, alkynylamino, cycloalkylamino, cycloalkenylamino, arylamino, aminocarbonyl, cyano, hydroxy, hydroxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkoxycarbonylamino, alkoxyarylalkylamino, alkylaminoalkylamino, hydroxyalkylamino, arylalkylamino, nitro, alkylaminocarbonyl, alkylcarbonylamino, halosulfonyl, aminoalkyl, haloalkyl, alkylcarbonyl, hydrazinyl, alkylhydrazinyl, arylhydrazinyl, and â€”NR44R45; and R44 is selected from the group consisting of alkylcarbonyl and amino; and R45 is selected from the group consisting of alkyl and arylalkyl; and R4 is phenyl, wherein: the phenyl may be optionally substituted with one or more substituents independently selected from the group consisting of halo, alkyl, alkenyl, alkynyl, aryl, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfinylalkyl, arylsulfinylalkyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, arylalkoxy, arninocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, and hydroxy.