Patent ID: 6867036
Filing Date: 2005-03-15
Classification: C12N

Abstract:
1. A composition comprising a nucleic acid, wherein said nucleic acid comprises: (a) a cell type-specific promoter for activating the expression of a gene in a specific cell type, wherein the cell type-specific promoter is human Tyr300 (SEQ ID. NO. 1); (b) a therapeutic gene sequence operably linked to said cell type-specific promoter; (c) an amplification promoter element for amplifying transcription of said therapeutic gene in said specific cell type, wherein said amplification promoter element is a heat shock element (HSE); and (d) a sequence encoding a transcription activator, said transcription activator for activating said amplification promoter element, and wherein said transcription activator is heat shock factor-1 (HSF-1).