Patent ID: 6803471
Filing Date: 2004-10-12
Classification: C07D

Abstract:
A method for producing an indolinospiroyran compound comprising the steps of:(i.) providing an indoline loaded resin of the formula: wherein wherein R1 is C1-C18 alkyl, allyl, phenyl, mono- or disubstituted phenyl, phen(C1-C4)alkyl, or (C1-C4)alkoxycarbonyl (C1-C4)alkyl, R2 and R3 are each independently C1-C4 alkyl, phenyl, mono- or di-substituted phenyl, benzyl, or combined to form a cyclic ring that is a cyclohexyl, norbornyl or adamantyl ring;(ii.) treating the loaded resin, under conditions suitable to form the indolinospiropyran compound, with a salicylaldehyde derivative of the formula: wherein R4 is hydrogen, hydroxy, trichloromethyl, trifluoromethyl, formyl, C1-C4 alkyl, halogen, C1-C4 alkoxy, nitro, cyano, C1-C1 monohaloalkyl, C1-C4 alkoxycarbonyl, or an aromatic sharing the two adjacent carbon atoms with the benzene portion of the pyran ring to form a condensed aromatic ring, and x equals 1, 2, or 3 to produce the indolinospiropyran compound; and(iii.) releasing the indolinospiropyran compound.