Patent ID: 8993538
Filing Date: 2015-03-31
Classification: A61K,A61L,A61P

Abstract:
1. A method of treating damaged cardiac tissue in a subject in need thereof, comprising administering a pharmaceutical preparation containing a cross-linked alginate polymer by injection or intra-arterial administration into damaged cardiac tissue of the subject, thereby treating the damaged cardiac tissue, wherein the pharmaceutical preparation is cross-linked by multivalent cations and has an elastic response equal to or greater than a viscous response with crossover between the viscous response and the elastic response in the linear viscoelastic limit (0.1-10 Hz), the alginate is present in an amount ranging from 0.1 to 4% (w/v) with a molecular weight ranging from 10-100 kDa, and the multivalent cations are present in an amount from 0.005-0.04% w/v.