Patent ID: 8796211
Filing Date: 2014-08-05
Classification: A61K,A61P

Abstract:
1. A method for treating a human patient for coronary artery disease, comprising: administering a therapeutically effective amount of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active, terminally truncated fragment of said FGF-2 into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for said coronary artery disease, wherein said therapeutically effective amount is about 0.2 μg/kg to 48 μg/kg of patient weight; wherein said recombinant FGF-2 is human FGF-2 and has the amino acid sequence set forth in SEQ ID NO: 2 with a threonine residue substituted for the serine residue at position 112 of SEQ ID NO: 2 and a serine residue substituted for the proline residue at position 128 of SEQ ID NO: 2, and wherein said fragment of said FGF-2 comprises at least residue numbers 30-110 of SEQ ID NO: 2.