Patent ID: 8945646
Filing Date: 2015-02-03
Classification: A23L,A61K,A61P,C07D

Abstract:
1. A method for manufacturing a polymethoxyflavone, the method comprising: (1) distilling a citrus plant peel oil under a pressure of 1 Pa to 100 Pa and at a temperature of 120° C. to 220° C. and thereby removing at least one volatile component to obtain a distillation residue (1); (2) distilling the distillation residue (1) with a thin-film vacuum distillation apparatus under a pressure of 0.1 Pa to 5 Pa and at a temperature of 190° C. to 260° C. to obtain a fraction (2); (3) extracting the fraction (2) with an aqueous ethanol solution to obtain an extract (3); and (4) after removing at least one insoluble oil, contacting the extract (3) with an active carbon to produce at least one polymethoxyflavone of formula (I): wherein: R the at least one polymethoxyflavone is highly stable over time and has a reduced residual pesticide level relative to polymethoxyflavones produced without the extracting (3) and the contacting (4).