Patent ID: 7772200
Filing Date: 2010-08-10
Classification: A61P,C12N

Abstract:
1. An iRNA agent comprising a sense strand and an antisense strand, wherein each strand is 21 nucleotides in length, and wherein the sequence of the sense strand is identical to the sense strand sequence of agent number 6662 (SEQ ID NO:557), and wherein the sequence of the antisense strand is identical to the antisense strand sequence of agent number 6662 (SEQ ID NO:558), and wherein every pyrimidine in the sense strand except for deoxythimidine is 2′-O-methyl modified, and wherein every 5′-nucleotide in 5′-ua-3′ motifs in the antisense strand is 2′-O-methyl modified, and wherein the 21 nucleotides include two deoxythymidine nucleotides at the 3′ end of each strand.