Patent ID: 8383844
Filing Date: 2013-02-26
Classification: C07D

Abstract:
1. A process, comprising: (a) producing (±)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan-2(1H)-ones by cyclizing a homofarnesylic acid amide or a monocyclohomofarnesylic acid amide in the presence of an acid agent, then hydrolyzing the cyclized product; (b) producing a crude (±)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan by subjecting the (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furan-2(1H)-ones to reduction reaction and then to a cyclization reaction; (c) treating the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furan by heating in the presence of an alcohol and a metal hydroxide; and (d) washing the treated (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furan with an aqueous acid solution.