Patent ID: 6696420
Filing Date: 2004-02-24
Classification: C07K,C12N

Abstract:
A method of transferring a nucleic acid sequence encoding a hepatitis B virus S antigen to a mammal to induce an antibody response against HBV S antigen in said mammal, comprising:administering a defective recombinant Ad2 adenoviral vector to the mammal intravenously, wherein the vector comprises: a) an E1A promoter; b) a deletion of the entire E1A coding region; and c) a nucleic acid sequence encoding the hepatitis B virus S antigen operatively linked to the E1A promoter; wherein the hepatitis B virus S antigen is expressed in the mammal, thereby inducing an antibody response to the hepatitis B virus S antigen in the mammal, wherein the antibody response is detectable in the blood of the mammal.