Patent ID: 6482800
Filing Date: 2002-11-19
Classification: A61K,A61P,C07K

Abstract:
A method for increasing blood flow to ischemic cardiac tissue comprising the administration of an amount effective for increasing blood flow to ischemic cardiac tissue of at least one active agent comprising a sequence of at least five contiguous amino acids of groups R1-R8 in the sequence of general formula IR1-R2â€”R3-R4-R5-R6-R7-R8 whereinR1 is selected from the group consisting of H, Asp, Glu, Asn, Acpc (1-aminocyclopentane carboxylic acid), Ala, Me2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2) and Suc; R2 is selected from the group consisting of Arg, Lys, Ala, Om, Ser(Ac), Sar, D-Arg and D-Lys; R3 is selected from the group consisting of Val, Ala, Leu, norLeu, Ile, Gly, Pro, Aib, Acpc and Tyr; R4 is selected from the group consisting of Tyr, Tyr(PO3)2, Thr, Ala, Ser, homoSer and azaTyr; R5 is selected from the group consisting of Ile, Ala, Leu, norLeu, Val and Gly; R6 is selected from the group consisting of His, Arg and 6-NH2-Phe; R7 is selected from the group consisting of Pro and Ala; and R8 is selected from the group consisting of Phe, Phe(Br), Ile and Tyr, or is absent; excluding sequences including R4 as a terminal Tyr group; and wherein the active agent is not AII.