Patent ID: 9102756
Filing Date: 2015-08-11
Classification: A23K,A61K,A61P,C07K

Abstract:
1. A proteinase-resistant analog of a biologically active peptide or polypeptide factor, which peptide or polypeptide factor has an amino acid sequence including a proteinase substrate sequence P 2 -P 1 -P′ 1 that is cleaved under physiological conditions by dipeptidyl peptidase IV (DPP IV), wherein said analog has an amino acid sequence corresponding to said peptide or polypeptide factor where the P′ 1 residue of said proteinase substrate sequence is replaced with an amino acid analog having a tetrasubstituted Cβ carbon, which P′ 1 residue replacement reduces the susceptibility of the analog to cleavage by DPP IV relative to said peptide or polypeptide factor; P the peptide or polypeptide factor is capable of binding a GLP-1, GLP-2, GIP, NPY, PP, or PYY receptor; the analog of the peptide or polypeptide factor is capable of binding a GLP-1, GLP-2, GIP, NPY, PP, or PYY receptor, and has an amino acid sequence at least 90% identical to GLP-1 (7-37) (SEQ ID NO:1), GLP-1 (7-36)NH the amino acid analog has the structure shown in Formula II: wherein R R mis 0,1, or 2.