Patent ID: 6716837
Filing Date: 2004-04-06
Classification: A61P,C07D,C07F

Abstract:
A compound selected from the group consisting of a compound of Formula I: wherein:W is a CH group or a N atom; Z is C-R4; B and D are selected independently from C and CH; A is a group of Formula III or IV, such that group A contains at least 1 N atom; NR7 is either â€”NHâ€” or â€”N&boxH;;  is a single or double bond; X is a N atom, a CH group or a C(OH) group when  is a single bond; or, when  is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH2 group; U and V each represent a N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to 3; d is an integer from 1 to 3; e is an integer from 1 to 2; f is an integer from 0 to 3; g is an integer from 3 to 6 and h is an integer from 2 to 3; such that the sum of c and d is at least 2 and the sum of e and f is at least 2; R1 is selected from the group consisting of H, alkyl including C(1-12)alkyl alkyloxy, alkanoyl, aminoalkylenyl, alkylaminoalkylenyl, a hydroxyalkylenyl group, an alkyloxyalkylenyl group, a cycloalkyl group, a cycloalkylalkylenyl group, a heterocycloalkyl group, a heterocycloalkylenyl group, an aryl group, a heteroaryl group, an amido group, a thioamido group, an arylcarbonyl group and an arylsulfonyl group; R4 is selected from the group consisting of H, alkyl and cycloalkyl; CR5 represents a group selected from â€”CH2â€”, CH(OH)â€”, â€”C(O)â€”, â€”CH(alkyl)- and â€”CH(alkyloxy)-; R6 is selected from the group consisting of H, alkyl, aryl, halogen, hydroxy, alkyloxy, amino, monoalkylamino and di-substitutedalkylamino; R8 is selected from the group consisting of â€”CHâ€” and â€”CH2â€” such that when R8 is bonded by one single bond and one double bond R8 is CH, and when R8 is bonded by two single bonds R8 is CH2, and salts thereof.