Patent ID: 8883148
Filing Date: 2014-11-11
Classification: A61K

Abstract:
1. A method for treating or reducing the risk of joint destruction in a joint or musculoskeletal disease, comprising identifying a subject suffering from the disease, and administering a composition consisting of a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier to the subject, wherein the joint or musculoskeletal disease is selected from the group consisting of osteonecrosis, Paget's disease, Gaucher's disease, abnormally increased bone turnover, osteoclasis, periprosthetic osteolysis, degenerative joint disease, osteoarthritis, gouty arthritis, osteogenesis imperfecta, and a joint damage resulting from trauma, surgery, chemotherapy, or radiotherapy.