Patent ID: 7267990
Filing Date: 2007-09-11
Classification: A61K,Y10T

Abstract:
1. A method for selectively binding a neutral, positively-charged, or negatively-charged molecule, in solution or in the solid state, said method comprising contacting the molecule with a compound comprising a porphyrin macrocycle, and further comprising one or more carboranyl groups that are linked to the porphyrin macrocycle by carbon-carbon bonding; wherein said selective binding comprises one or more of the following steps (a) through (c): (a) coordination to a pentacoordinated or hexacoordinated metal ion in the core of the porphyrin macrocycle; or (b) electrostatic interaction with one or more carboranyl groups; or (c) π-π interaction with the porphyrin macrocycle; wherein the compound has structure I: wherein M is 2H or a pentacoordinated or hexacoordinated metal ion; R1 and R2 are each independently hydrogen, C 1 to C 4 alkyl or hydroxyalkyl; and R3, R4, R5, and R6 are each independently hydrogen, phenyl, or substituted phenyl having structure II: wherein R7, R8, R9, R10, and R11 are independently hydrogen or a carboranyl group, wherein such a carboranyl group is linked to the phenyl group by a carbon-carbon bond; and wherein one or two of R7, R8, R9, R10, and R11 are such a carboranyl group; wherein at least one of R3, R4, R5, and R6 is a substituted phenyl having structure II and having at least one such a carboranyl group; and wherein one or more of the following conditions (d) through (f) are satisfied: (d) M is an iron(III), manganese(III), aluminum(III), or tin(IV) ion; or (e) at least one of R3, R4, R5, and R6 is a substituted phenyl having structure II and having at least one such carboranyl group at R7 or R11; or (f) at least one of the carboranyl groups is a closo-carboranyl group.