Patent ID: 8921074
Filing Date: 2014-12-30
Classification: C12Q,G01N,G16B

Abstract:
1. A method for identifying whether a human test subject is more likely to have colorectal cancer than to not have colorectal cancer, comprising (a) amplifying test DNA from blood of the human test subject complementary to a test mRNA to obtain values for levels of test mRNA expressed specifically by a set of genes consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1, comprising the steps of (b) comparing the product of step (a) to the value for the level of control mRNA expressed specifically by the set of genes consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1 obtained from blood of a human control subject, the human control subject not having colorectal cancer, wherein the value for the level of test mRNA encoded by the ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6 and/or VNN1 gene in the human test subject higher than the level of control mRNA encoded by the ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6 and/or VNN1 gene in the human control subject identifies the human test subject as more than likely to have colorectal cancer and wherein the value for the level of test mRNA encoded by the IL2RB gene in the human test subject lower than the level of control mRNA encoded by the IL2RB gene in the human control subject identifies the human test subject as more than likely to have colorectal cancer.