Patent ID: 8470967
Filing Date: 2013-06-25
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. An environmentally responsive polypeptide comprising at least ten repeats of an amino acid sequence Z 1 Z 2 PX 1 X 2 X 3 X 4 GZ 3 , wherein P is Proline, G is Glycine, X 1 , X 2 , X 3 and X 4 are an amino acid that is not Proline or Glycine and X 1 , X 2 and X 3 are optionally absent, Z 1 , Z 2 and, Z 3 are each an amino acid, and wherein the polypeptide upon stimulation undergoes a conformational change that is accompanied by aggregation.