Patent ID: 7265088
Filing Date: 2007-09-04
Classification: A61K

Abstract:
1. A method of reducing mucus hypersecretion in the airways of a subject suffering from asthma comprising administration to the airways of said subject a pharmaceutical formulation comprising a mucus-inhibitory amount of a N-terminal myristoylated peptide selected from the group consisting of the MANS peptide and a N-terminal myristoylated peptide fragment thereof comprising at least the first 10 amino acids of the MANS peptide, wherein said MANS peptide consists of a N-terminal myristoylated peptide of SEQ ID NO: 1, wherein said N-terminal myristoylated peptide reduces MARCKS protein-related mucus hypersecretion, and whereby mucus hypersecretion in said airways is reduced compared to that which would occur in the absence of said peptide.