Patent ID: 6815449
Filing Date: 2004-11-09
Classification: A61P,C07D

Abstract:
A compound represented by formula (IA): wherein R1 represents lower alkyl (optionally substituted by one or more substituents independently selected from the group consisting of lower alkyl, hydroxy, lower alkoxy and halogen), lower alkanoyl (the lower alkyl moiety being optionally substituted by one or more substituents independently selected from the group consisting of lower alkyl, hydroxy, lower alkoxy and halogen), carboxy, lower alkoxycarbonyl, (wherein n represents 1 or 2) or COCH&boxH;CHR9 {wherein R9 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or NR10R11 (wherein R10 and R11 independently represent hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl-substituted lower alkyl, substituted or unsubstituted tetrahydropyranyl, or substituted or unsubstituted tetrahydropyranylmethyl, or R10 and R11 are combined together with the adjoining N to form a substituted or unsubstituted heterocyclic group)};R4 and R5 independently represent hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; R6 represents hydrogen or halogen; and R7 and R8 independently represent hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; or a pharmaceutically acceptable salt thereof, with the proviso that R1 cannot represent (E)-3-methoxyacryloyl when R4, R5, R6 and R7 represent hydrogen and R8 is acetyl.