Patent ID: 6656964
Filing Date: 2003-12-02
Classification: A61P,C07D

Abstract:
A method of inhibiting a phosphodiesterase in a mammal which comprises administering an effective amount of a hydroxamic acid derivative selected from the group consisting ofa compound of the formula: wherein R4â€² is hydrogen or alkyl of 1 to 4 carbon atoms; R5 is C&boxH;O or CH2; each of R12 and R13, independently of the other, is alkoxy of 1 to 4 carbon atoms, cylcoalkoxy of 3 to 6 carbon atoms; C4-C6-cycloalkylidenemethyl, C2-C10-alkylidenemethyl, C6-C10-bicycloalkoxy, or indanyloxy; and each of R8, R9, R10, and R11, independently of the others, is hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkylamino, dialkylamino, acylamino, alkyl of 1 to 10 carbon atoms, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, or halo.