Patent ID: 6248348
Filing Date: 2001-06-19
Classification: A61K,Y10S

Abstract:
A method for enhancing the transdermal flux of a drug from a transdermal device comprising:(a) incorporating into a reservoir of a transdermal 5-25 wt % poly-N-vinyl-2-pyrrolidone, wherein said device comprises:(i) a reservoir containing an estrogen and a progestin and a permeation enhancing amount of a monoglyceride or a mixture of monoglycerides of a fatty acid with a total monoesters content of at least 51% or a lactic ester of an alcohol, separately or in combination, said estrogen, progestin, and permeation enhancer being dispersed and/or dissolved in a polymeric carrier;(ii) a backing layer adjacent the skin distal surface of the device;(iii) means for maintaining the reservoir in drug and permeation enhancer transmitting relation with the skin; and(b) placing the device onto the skin of a person.