Patent ID: 7276495
Filing Date: 2007-10-02
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is —(CR 7 R 7a ) m —R 4 , —(CR 7 R 7a ) n —S—R 4 , —(CR 7 R 7a ) n —O—R 4 , —(CR 7 R 7a ) m —N(R 7b )—R 4 , —(CR 7 R 7a ) n —S(═O)—R 4 , —(CR 7 R 7a ) n —S (═O) 2 —R 4 , or —(CR 7 R 7a ) n —C(═O)—R 4 ; provided when n is 0, then R 4 is not H; m is 1, 2, or 3; n is 0, 1, or 2; R 4 is H, C 1 -C 8 alkyl substituted with 0-3 R 4a , C 2 -C 8 alkenyl substituted with 0-3 R 4a , C 2 -C 8 alkynyl substituted with 0-3 R 4a , C 3 -C 10 carbocycle substituted with 0-3 R 4b , aryl substituted with 0-3 R 4b , or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 4a , at each occurrence, is independently selected from is H, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , OR 14a , OR 22 , SR 22 , C(═O)OR 22 , NR 21 R 22 , S(═O)R 22 , S(═O) 2 R 22 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 haloalkyl-S—, C 3 -C 10 carbocycle substituted with 0-3 R 4b , aryl substituted with 0-3 R 4b , and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 4b , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, and C 1 -C 4 haloalkyl-S—; R 5 is H; C 1 -C 6 alkyl substituted with 0-3 R 5b ; C 2 -C 6 alkenyl substituted with 0-3 R 5b ; C 2 -C 6 alkynyl substituted with 0-3 R 5b ; C 3 -C 10 carbocycle substituted with 0-3 R 5c ; aryl substituted with 0-3 R 5c ; and 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 5b , at each occurrence, is independently selected from: H, C 1 -C 6 alkyl, CF 3 , Cl, F, Br, I, ═O, CN, NO 2 , NR 15 R 16 ; C 3 -C 10 carbocycle substituted with 0-3 R 5 ; aryl substituted with 0-3 R 5c ; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 5c , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, and C 1 -C 4 haloalkoxy, and C 1 -C 4 haloalkyl-S—; R 6 is H; C 1 -C 6 alkyl substituted with 0-3 R 6a ; C 3 -C 10 carbocycle substituted with 0-3 R 6b ; or aryl substituted with 0-3 R 6b ; R 6a , at each occurrence, is independently selected from H, C 1 -C 6 alkyl, OR 14 , Cl, F, Br, I, ═O, CN, NO 2 , NR 15 R 16 , aryl or CF 3 ; R 6b , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, and C 1 -C 4 haloalkoxy; R 7 , at each occurrence, is independently H or C 1 -C 4 alkyl; R 7a , at each occurrence, is independently H or C 1 -C 4 alkyl; R 7b is H or C 1 -C 4 alkyl; Ring B is selected from: R 11 , at each occurrence, is independently selected from H, C 1 -C 4 alkoxy, Cl, F, Br, I, ═O, CN, NO 2 , NR 18 R 19 , C(═O)R 17 , C(═O)OR 17 , C(═O)NR 18 R 19 , S(═O) 2 NR 18 R 19 , CF 3 ; C 1 -C 6 alkyl optionally substituted with 0-3 R 11a , aryl substituted with 0-3 R 11b ; C 3 -C 10 carbocycle substituted with 0-3 R 11b ; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 11a , at each occurrence, is independently selected from H, C 1 -C 6 alkyl, OR 14 , Cl, F, Br, I, ═O, CN, NO 2 , NR 15 R 16 , CF 3 ; phenyl substituted with 0-3 R 11b ; C 3 -C 6 cycloalkyl substituted with 0-3 R 11b ; and 5 to 6 membered heterocycle containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 6 membered heterocycle is substituted with 0-3 R R 11b , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, and C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, and C 1 -C 4 haloalkyl-S—; W is a bond or —(CR 8 R 8a ) p —; p is 0, 1, 2, 3, or 4; R 8 and R 8a , at each occurrence, are independently selected from H, F, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl and C 3 -C 8 cycloalkyl; X is a bond; aryl substituted with 0-3 R Xb ; C 3 -C 10 carbocycle substituted with 0-3 R Xb ; or 5 to 10 membered heterocycle substituted with 0-2 R R Xb , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, and C 1 -C 4 halothioalkoxy; Y is a bond or —(CR 9 R 9a ) t -V—(CR 9 R 9a ) u —; t is 0, 1, or 2; u is 0, 1, or 2; R 9 and R 9a , at each occurrence, are independently selected from H, F, C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl; V is a bond, —C(═O)—, —O—, —S—, —S(═O)—, —S(═O) 2 —, —N(R 19 )—, —C(═O)NR 19b —, —NR 19b C(═O)—, —NR 19b S(═O) 2 —, —S(═O) 2 NR 19b —, —NR 19b S(═O)—, —S(═O)NR 19b —, —C(═O)O—, or —OC(═O)—; Z is H; C 1 -C 8 alkyl substituted with 0-3 R 12a ; C 2 -C 6 alkenyl substituted with 0-3 R 12a ; C 2 -C 6 alkynyl substituted with 0-3 R 12a ; aryl substituted with 0-4 R 12b ; C 3 -C 10 carbocycle substituted with 0-4 R 12b ; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 12a , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 15 R 16 , —C(═O)NR 15 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 haloalkyl-S—, aryl substituted with 0-4 R 12b ; C 3 -C 10 carbocycle substituted with 0-4 R 12b ; or 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R R 12b , at each occurrence, is independently selected from H, OH, Cl, F, Br, I, CN, NO 2 , NR 16 R 16 , CF 3 , acetyl, SCH 3 , S(═O)CH 3 , S(═O) 2 CH 3 , aryl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, and C 1 -C 4 haloalkyl-S—; R 13 , at each occurrence, is independently selected from C 1 -C 6 alkyl, C 2 -C 4 alkoxy, Br, CN, NO 2 , and NR 15 R 16 , R 14 is H, phenyl, benzyl, C 1 -C 6 alkyl, C 2 -C 6 alkoxyalkyl, or C 3 -C 6 cycloalkyl; R 14a is H, phenyl, benzyl, or C 1 -C 4 alkyl; R 15 , at each occurrence, is independently selected from H, C 1 -C 6 alkyl, benzyl, phenylethyl, (C 1 -C 6 alkyl)-C(═O)—, and (C 1 -C 6 alkyl)-S(═O) 2 —; R 16 , at each occurrence, is independently selected from H, OH, C 1 -C 6 alkyl, benzyl, phenylethyl, (C 1 -C 6 alkyl)-C(═O)—, and (C 1 -C 6 alkyl)-S(═O) 2 —; alternatively, R 15 and R 16 , together with the nitrogen to which they are attached, may combine to form a 4-7 membered ring wherein said 4-7 membered ring optionally contains an additional heteroatom selected from O or NH; R 17 is H, C 1 -C 6 alkyl, C 2 -C 6 alkoxyalkyl, aryl substituted by 0-4 R 17a , or —CH 2 -aryl substituted by 0-4 R 17a ; R 17a is H, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, —OH, F, Cl, Br, I, CF 3 , OCF 3 , SCH 3 , S(O)CH 3 , SO 2 CH 3 , —NH 2 , —N(CH 3 ) 2 , or C 1 -C 4 haloalkyl; R 18 , at each occurrence, is independently selected from H, C 1 -C 6 alkyl, phenyl, benzyl, phenylethyl, (C 1 -C 6 alkyl)-C(═O)—, and (C 1 -C 6 alkyl)-S(═O) 2 —; R 19 , at each occurrence, is independently selected from H, OH, C 1 -C 6 alkyl, phenyl, benzyl, phenylethyl, (C 1 -C 6 alkyl)-C(═O)—, and (C 1 -C 6 alkyl)-S(═O) 2 —; R 19b , at each occurrence, is independently is H or C 1 -C 4 alkyl; R 21 is H, phenyl, benzyl, or C 1 -C 4 alkyl; and R 22 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, or C 3 -C 4 alkynyl.