Patent ID: 6110962
Filing Date: 2000-08-29
Classification: A61K,C07D

Abstract:
A compound of formula I having the structure ##STR19## wherein A is hydrogen, halogen, or OH;B and D are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, nitro, amino or OR;R is hydrogen, alkyl of 1-6 carbon atoms, -COR.sup.1, -CH.sub.2 CO.sub.2 R.sup.1, -CH(R.sup.1a)CO.sub.2 R.sup.1, or -SO.sub.2 R.sup.1 ;R.sup.1 and R.sup.1a are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms or aryl;E is S, SO, SO.sub.2, O;X is hydrogen, halogen, alkyl of 1-6 carbon atoms, CN, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy of 6-12 carbon atoms, nitro, amino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, or -OCH.sub.2 CO.sub.2 R.sup.1b ;R.sup.1b is hydrogen or alkyl of 1-6 carbon atoms;Y and Z are each, independently, hydrogen or OR.sup.2 ;R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, or -CH.sub.2 CO.sub.2 R.sup.3 ;R.sup.3 is hydrogen or alkyl of 1-6 carbon atoms;C is hydrogen, halogen or OR.sup.4 ;R.sup.4 is hydrogen, alkyl of 1-6 carbon atoms, -CH(R.sup.5)W, -C(CH.sub.3).sub.2 CO.sub.2 R.sup.6, 5-thiazolidine-2,4-dione, -CH(R.sup.7)CH.sub.2 CO.sub.2 R.sup.6, -COR.sup.6, PO.sub.3 (R.sup.6).sub.2, or -SO.sub.2 R.sup.6 ;R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl, aryl, CH.sub.2 (1 H-imidazol-4-yl), -CH.sub.2 (3-1 H - indolyl), -CH.sub.2 CH.sub.2 (1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH.sub.2 CH.sub.2 (1-oxo-1,3-dihydro-isoindol-2-yl), -CH.sub.2 (3-pyridyl), or -CH.sub.2 CO.sub.2 H;W is -CO.sub.2 R.sup.6, -CONH.sub.2, -CONHOH, CN, -CONH(CH.sub.2).sub.2 CN, 5-tetrazole, -PO.sub.3 (R.sup.6).sub.2, -CH.sub.2 OH, or -CH.sub.2 Br, -CONR.sup.6 CHR.sup.7 CO2R.sup.8,R.sup.6 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl;R.sup.7 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl;R.sup.8 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl;with the proviso that at least one of A,B,C, and D is not hydrogen or a pharmaceutically acceptable salt thereof.