Patent ID: 6039931
Filing Date: 2000-03-21
Classification: A61K,C07C,C07F

Abstract:
A method of enhancing an NMR image comprising administering to a patient a compound of the formula ##STR4## wherein one of Z.sup.1 and Z.sup.2 is H and the other is--(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,whereinm and n, independently, are each 0-20,k, l, q and r are each, independently, 0 or 1,R is H, C.sub.1 -C.sub.6 -alkyl, OR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl or CH.sub.2 COOR.sup.1,R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl or benzyl; andX is, in each case, a hydrogen atom or a metal ion equivalent of an element of atomic number 21-29, 42, 44 or 58-70;with the provisos that:at least two X groups represent a metal ion equivalent of atomic number 21-29, 42, 44 or 58-70;when n and l are each 0, then k and r are not each simultaneously 1;--(O).sub.r -R is not --OH;Z.sup.1 and Z.sup.2 are not --C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOCH.sub.2 C.sub.6 H.sub.5 or --CH.sub.2 --C.sub.6 H.sub.4 --O--(CH.sub.2).sub.5 --COOCH.sub.2 C.sub.6 H.sub.5 ; andat least one of q and l is 1;or a physiologically acceptable salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide.