Patent ID: 6525055
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound of formula (I) whereinA is a 5-7 membered heterocycle having from 1 to 4 nitrogen atoms, optionally partially or totally unsaturated, and optionally substituted by a (C1-4)alkyl group in turn optionally substituted; Z is NH, methylene, a C2-6 alkylene chain optionally branched and/or unsaturated and/or interrupted by a C5-7 cycloalkyl residue; Cy is phenyl or heterocycle optionally substituted by one or more substituents, or a COR4 group wherein R4 is hydroxy, alkoxy, amino optionally substituted by one or two (C1-6)alkyl groups or by hydroxy; R is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; R1 is hydrogen; a (C1-8)-alkyl, (C2-8)-alkenyl or (C2-8)-alkynyl group optionally substituted by hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatoms or heterogroups; a (C1-4)alkoxy group or a (C4-7)cycloalkoxy group optionally having an oxygen atom and optionally substituted by a polar substituent in the cyclic moiety, aryloxy, aryl-(C1-10)-alkoxy wherein the polar substituent is selected from the group consisting of a hydroxy and keto group; the Nâ†’O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof.