Patent ID: 8188239
Filing Date: 2012-05-29
Classification: A61K,A61P,B82Y,C07K

Abstract:
1. A composition comprising a tetravalent targetable complex comprising the structure (IgG1) 2 -(scFv) 4 , wherein said tetravalent targetable complex is formed by linking two IgG1-(scFv) 2 molecules with a targetable construct comprising four DTPA (diethylenetriamine-pentaacetic acid) residues, wherein each IgG1-(scFv) 2 molecule comprises a pair of heavy chains and a pair of light chains, wherein each heavy chain comprises a humanized, chimeric or human IgG1 heavy chain and an scFv, wherein said scFv is fused to the C-terminus of said IgG1 heavy chain, wherein each scFv binds to a DTPA residue and wherein greater than 75% of the complexes in the composition have a stoichiometry of two molecules of IgG1-(scFv) 2 and one molecule of the targetable construct.