Patent ID: 7422908
Filing Date: 2008-09-09
Classification: C07F

Abstract:
1. An alkene intermediate corresponding to the formula: wherein R 7 is selected from the group consisting of alkyl, aryl, aralkyl, alkaryl, heteroalkyl, heteroaryl, cycloalkyl, cycloheteroalkyl, alkyletheralkyl, alkyletheraryl, alkyl (etheralkyl) 2 , alkyl (etheralkyl) 3 , alkyletherhaloalkyl, alkyl(etherhaloalkyl) 2 , alkylalkene, alkylalkyne, arylalkene, arylalkyne, halogenated alkyl (mono, di, tri or any position in normal or branched or cyclic chain), alkylalcohol, alkylnitrile, alkylamine, alkylacid, (mono or dibasic) or the inorganic salts thereof, haloalkylalcohol, haloalkylnitrile, haloalkylamine, haloalkylacid, mono or dibasic, or the inorganic salts thereof, a linker-fluorescent molecule, a linker-antibody , a linker-antigen, a linker-biotin, a linker-avidin, a linker-protein, a linker-carbohydrate or a linker-lipid; Ar is aryl and may be phenyl, substituted phenyl, naphthyl, substituted naphthyl, anthryl, substituted anthryl, or other fluorescent or non-fluorescent aromatic group; Y is a hydrogen, alkyl, acetate, t-butyldimethylsilyl or an enzyme cleavable group, or an antibody cleavable group and R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, alkylaryl or substituted alkylaryl, arylalkyl or substituted arylalkyl; X is chloro or hydrogen.