Patent ID: 6689799
Filing Date: 2004-02-10
Classification: C07D

Abstract:
A compound of formula I: wherein:R is CN, NO2, or a â€”COORâ€² group, wherein Râ€² is a lower alkyl group; R1 is R6 or R4; R2 is a lower alkoxy or R4; R3 is H or R4; R4 is a coumarin group of formula II: R5 is H, lower alkyl, lower alkoxy, halogene, nitro, hydroxyl or amino; R6 is H, lower alkyl, lower alkoxy, benzyloxy, cyano, nitro, carboxylic acid or carboxamide; X is a single bond, â€”(CH2)nâ€”Oâ€”, of â€”(CH2)mâ€”Yâ€”(CH2)kâ€”O, wherein n is from 1 to about 6, m and k are each equal to or greater than 1 and the sum of m and k is equal to or less than 4; Y is phenylene, cycloalkylene or a carbon atom substituted with 1 or 2 C1-C2-alkyl groups; wherein lower alkyl, lower alkoxy, benzyloxy, phenylene and cycloalkylene may be substituted with 1-3 groups chosen from hydroxyl, cyano, amino, halogen and nitro; wherein at least one of the groups R1, R2 and R3 is R4 or an N-oxide, stereoisomer or addition salt thereof with a pharmaceutically acceptable acid or base.