Patent ID: 6849650
Filing Date: 2005-02-01
Classification: A61K

Abstract:
1. A compound of formula I: wherein A is selected from the group consisting of: where R Z is selected from the group consisting of (a) a group having the formula —CX′X″C(O)— where X′ is hydrogen, hydroxy or fluoro; X″ is hydrogen, hydroxy or fluoro, or X′ and X″ together form an oxo group; (b) a group having the formula -T-CX′X″C(O)— where T is selected from the group consisting of oxygen, sulfur and —NR (c) a group having the formula —CX′X″-T-C(O)— where T is selected from the group consisting of oxygen, sulfur and —NR R R m is an integer equal to 0 or 1: and p is an integer equal to 0 or 1; where R T′ is selected from the group consisting of a bond covalently linking R W and X are independently selected from the group consisting of —(CR and with the further proviso that when W is oxygen, then X is not also oxygen; X′ is hydrogen, hydroxy or fluoro, X″ is hydrogen, hydroxy or fluoro, or X′ and X″ together form an oxo group; R where R T′ is selected from the group consisting of a bond covalently linking R W and X are independently selected from the group consisting of —(CR X′ is hydrogen, hydroxy or fluoro, X″ is hydrogen, hydroxy or fluoro, or X′ and X″ together form an oxo group; R B is selected from the group consisting of: where R W and X are independently selected from the group consisting of (CR and with the further proviso that when W is oxygen, then X is not also oxygen; R W and X are independently selected from the group consisting of (CR R (iv) when A is either formula (ii) or (iii) as defined above, then B can also be a covalent bond linking A to C; C is selected from the group consisting of: where Y is selected from the group consisting of: (a) alkyl or cycloalkyl, (b) substituted alkyl with the proviso that the substitution on said substituted alkyl do not include a-haloalkyl, α-diazoalkyl, α-OC(O)alkyl, or α-OC(O)aryl groups, (c) alkoxy or thioalkoxy, (d) substituted alkoxy or substituted thioalkoxy, (e) hydroxy, (f) aryl, (g) heteroaryl, (h) heterocyclic, (i) —NR′R″ where R′ and R″ are independently selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, substituted alkenyl, cycloalkyl, aryl, heteroaryl, heterocyclic, where one of R′ or R″ is hydroxy or alkoxy, and where R′ and R″ are joined to form a cyclic group having from 2 to 8 carbon atoms optionally containing 1 to 2 additional heteroatoms selected from oxygen, sulfur and nitrogen and optionally substituted with one or more alkyl, alkoxy or carboxylalkyl groups, (j) —NHSO (k) —NR (l) —ONR where each R where A, together with —C═N—, forms a heterocyclic group which is optionally fused to form a bi- or multi-fused ring system (preferably no more than 5 fused rings) with one or more ring structures selected from the group consisting of cycloalkyl, cycloalkenyl, heterocyclic, aryl and heteroaryl group which, in turn, each of such ring structures is optionally substituted with 1 to 4 substituents selected from the group consisting of hydroxyl, halo, alkoxy, substituted alkoxy, thioalkoxy, substituted thioalkoxy, nitro, cyano, carboxyl, carboxyl esters, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl, heterocyclic, —NHC(O)R with the proviso that when A has structure (i) and B has structure (i), then C does not have structure (i) or (ii); with the further provisos that A. when A has structure (i) with R B. when A has structure (i) with R C. when A has structure (ii) wherein R D. when A has structure (i) wherein R