Patent ID: 7749999
Filing Date: 2010-07-06
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A cytokine inhibitor having Formula IA: stereoisomers thereof; tautomers thereof, and pharmaceutically acceptable salts thereof, wherein: X is C(O)or C(S); G is a C Ar is —(Y)—(C Y is —C(O)—, —C(NNRC(O)OR)—, —C(NNRR)—, —C(NNHC(O)NRR)— or —C(NOR)—; L is a covalent bond or a saturated or unsaturated branched or unbranched C each m is independently 0, 1 or 2; Q is —NR′R′, cycloalkyl, aryl, heterocyclyl, C each R is independently hydrogen or substituted or unsubstituted C each R′ is independently hydrogen, substituted or unsubstituted C each R each R each R″ is independently substituted or unsubstituted C each R each R each R R R each R each R provided however that when Ar is —(Y)-(bicyclic aryl) and G is N-(substituted or unsubstituted phenyl)-pyrazolyl, the pyrazolyl is additionally substituted with one or more R IA is not N-(4-chloro-3-methyl-isothiazol-5-yl)-2-[2-(2,2-dimethyl-propyl)-benzooxazol-5-yl]-2-oxo-acetamide.