Patent ID: 9035022
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K

Abstract:
1. A cyclic corticotropin releasing factor (CRF) antagonist peptide, or a pharmaceutically acceptable salt thereof, which peptide has the amino acid sequence: wherein Y is an acyl group having up to 20 carbon atoms; R 17 is Glu or C α CH 3 -L-leucine (CML); R 19 is 2-aminoisobutyric acid (Aib), CML, C α CH 3 -L-phenylalanine (CMP), or C α CH 3 -L-valine (CMV); R 24 is Aib, CML, D-CML, D-Aph(Cbm) or D-Aph(Hor); R 26 is Asn or Aib, R 32 is CMP, CMV, CML, or Aib.