Patent ID: 9221827
Filing Date: 2015-12-29
Classification: A61P,C07D

Abstract:
1. A compound having the formula: or a tautomer thereof, or a pharmaceutically acceptable salt, ester, or prodrug of said compound or tautomer, wherein X Y R wherein each (ff) through (nn) is optionally substituted with one or more R alternatively, wherein two substituents selected from R 6 , R 7 , and R 8 are taken together with the carbon atom to which they are attached to form (a) -3-7 membered saturated or unsaturated carbocyclic or (b) -3-7 membered saturated or unsaturated heterocyclic ring containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; wherein each (a) through (b) is optionally substituted with one or more R 12 ; each R wherein each (y) through (hh) is optionally substituted with one or more R alternatively two R R wherein R wherein each (s) through (x) is optionally substituted with one or more R alternatively, one or more pairs of substituents selected from R wherein each (a) through (b) is optionally substituted with one or more R alternatively, wherein two substituents selected from R wherein each (a) through (b) is optionally substituted with one or more R alternatively, wherein two substituents selected from R U is selected from —O—, —S(O) T is selected from —NR alternatively, one R wherein each (a) through (b) is optionally substituted with one or more R R wherein R wherein each (r) through (w) is optionally substituted with one or more R alternatively, one or more pairs of substituents selected from R wherein each (a) through (c) is optionally substituted with one or more R alternatively, two substituents selected from R wherein each (a) through (b) is optionally substituted with one or more R alternatively, two substituents selected from R Z is selected from —O—, —S(O) W is selected from —NR alternatively, one R wherein each (a) through (b) is optionally substituted with one or more R R wherein each (aa) through (jj) is optionally substituted with one or more R R 13 is independently selected from (a) hydrogen, (b) halogen, (c) —C 1 -C 8 alkyl, (d) —C 2 -C 8 alkenyl, (e) —C 2 -C 8 alkynyl, (f) -haloalkyl, (g) —OH, (h) —OC 1 -C 8 alkyl, (i) —OC 2 -C 8 alkenyl, (j) —OC 2 -C 8 alkynyl, (k) —OCF 3 , (l) —OCH 3 , (m) —OCF 2 H, (n) —OCFH 2 , (o) —NH 2 , (p) —CN, (q) —N 3 , (r) —S(O) p C 1 -C 8 alkyl, (s) -3-14 membered saturated, unsaturated, or aromatic heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and (t) -3-14 membered saturated, unsaturated, or aromatic carbocycle; p is 0, 1, or 2; and t is 0, 1, or 2.