Patent ID: 8716448
Filing Date: 2014-05-06
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A recombinant factor VII fusion protein comprising a factor VII polypeptide fused to an extended recombinant polypeptide (XTEN), wherein the XTEN comprises at least 36 amino acid residues, which comprises an amino acid sequence that has at least 90% sequence identity to SEQ ID NO: 36, and wherein the XTEN is characterized in that (a) the sum of glycine (G), aspartate (D), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P) residues constitutes at least 80% of the total amino acids of the XTEN; and (b) the XTEN is non-repetitive such that