Patent ID: 6326166
Filing Date: 2001-12-04
Classification: C07K

Abstract:
A nucleic acid encoding a chimeric protein comprising a composite nucleic acid-binding region, wherein the composite nucleic acid-binding region comprises(a) at least two nucleic acid-binding domains, each of which binds a portion of the composite binding site, and wherein at least two of these nucleic acid-binding domains(i) do not occur in the same protein in nature;(ii) do not occur in the same protein in the order in which they are present in the chimeric protein; or(iii) do not occur in nature with the same spacing that is present in the chimeric protein, and(b) at least one additional domain, distinct from said nucleic acid-binding domains, which binds to a ligand and mediates formation of protein-protein complexes in a ligand-dependent manner.