Patent ID: 6025354
Filing Date: 2000-02-15
Classification: A61P,C07D

Abstract:
A method of treating an asthmatic disorder, inhibiting the formation of TNF, inhibiting the formation of phosphodiesterase IV, or treating allergic or inflammatory diseases, comprising administering an effective amount of a compound of formula I ##STR4## wherein R.sup.1 and R.sup.2 are each independently H or A,R.sup.3 and R.sup.4 are each independently --OH, OR.sup.10, --S--R.sup.10, --SO--R.sup.10, --SO.sub.2 --R.sup.10, Hal, methylenedioxy, --NO.sub.2, --NH.sub.2, --NHR.sup.10 or --NR.sup.10 R.sup.11,R.sup.5 is a phenyl radical which is unsubstituted or is mono- or disubstituted by R.sup.6 and/or R.sup.7,Q is absent or is C.sub.1-6 alkylene,R.sup.6 and R.sup.7 are each independently --NH.sub.2, --NR.sup.8 R.sup.9, --NHR.sup.10, --NR.sup.10 R.sup.11, --NO.sub.2, Hal, --CN, --OA, --COOH or --COOA,R.sup.8 and R.sup.9 are each independently H, C.sub.1-8 -alkanoyl optionally substituted by 1-5 fluorine and/or chlorine atoms, --COOA, --S--A, --SO--A, --SO.sub.2 A, --CONH.sub.2, --CONHA, --CONA.sub.2, --CO--COOH, --CO--COOA, --CO--CONH.sub.2, --CO--CONHA or --CO--CONA.sub.2,A is C.sub.1-6 -alkyl optionally substituted by 1-5 fluorine and/or chlorine atoms,R.sup.10 and R.sup.11 are each independently A, C.sub.3-7 -cycloalkyl, C.sub.4-8 -methylenecycloalkyl or C.sub.2-8 -alkenyl,andHal is F, Cl, Br or I,or a physiologically acceptable salt thereof.