Patent ID: 6712963
Filing Date: 2004-03-30
Classification: A61J,A61M,B01D,B65B

Abstract:
A manifold system for biotechnology uses, comprising:a manifold unit which is pre-sterilized and disposable so as to be adapted for single-time usage, including: (a) at least one length of tubing having at least one inlet end portion, at least one outlet end portion, an outside surface, and an inside surface which is sterilized for passage of a biotechnology fluid therethrough, (b) at least one single-use bag having a primary access port, and (c) an aseptic connector means for operatively connecting said length of tubing with said primary access port of the single-use bag; and a plurality of pinch valves, at least one of which is remotely operable in response to a signal remote from said pinch valve, each said pinch valve engages said outside surface of the length of tubing at a discrete location therealong, each said pinch valve independently selectively allowing or stopping flow of the biotechnology fluid through said inside surface of the length of tubing at said discrete location for that pinch valve; and wherein said system is for automated preparative chromatography, wherein said tubing is in at least two sections including a chromatography feed section and a chromatographed fluid section, wherein said chromatography feed section has an outlet and a plurality of serially arranged inlet passageways having one of said aseptic connector means for operable connection with said single-use bag, wherein said chromatographed fluid section has an inlet and said outlet end portion of the tubing which has a plurality of serially arranged outlet passageways having one of said aseptic connector means for operable connection with said single-use bag, wherein said pinch valves control passage of the biotechnology fluid from said single-use bags to the chromatography feed section, and wherein another said pinch valve controls passage of the biotechnology fluid from the tubing chromatographed fluid section to the single-use bag of the chromatographed fluid section.