Patent ID: 6241968
Filing Date: 2001-06-05
Classification: A61K,C07C,C07D,C08F,Y10S

Abstract:
An MRI contrast enhancer compound consisting of a complex of MRI-responsive paramagnetic metals chelated with an acrylic cycle chelate compound of the formula:(R.sup.1 R.sup.2)C.dbd.CR.sup.3 --CO--Z--A (1)in monomer, oligomer, homopolymer or copolymer form, in which R.sup.1, R.sup.2 and R.sup.3 represent H or a saturated or an unsaturated C.sub.1-10 aliphatic radical optionally substituted by one or more OH groups; Z is a covalent bond or a spacer linker and A is a cycle chelate moiety capable of complexing a paramagnetic metal by chelation.