Patent ID: 7205103
Filing Date: 2007-04-17
Classification: A61K,C07K,C12N

Abstract:
1. A method to identify a compound that modulates chromatin remodeling of a specific DNA sequence within chromatin comprising: a) providing chromatin assembled DNA containing a specific DNA sequence, which specific DNA sequence comprises a binding site for a zinc finger DNA binding domain of a nucleic acid regulatory protein, which zinc finger DNA binding domain interacts directly with a SWI/SNF chromatin remodeling complex comprising BRG1; b) contacting the chromatin assembled DNA with: c) determining the level of chromatin remodeling in the presence and absence of a test compound; wherein a difference in the level of chromatin remodeling in the presence and absence of the test compound identifies the test compound as a compound that modulates chromatin remodeling of the specific DNA sequence within chromatin.