Patent ID: 6335352
Filing Date: 2002-01-01
Classification: A61K,A61P,Y02A

Abstract:
A method of treating a chemokine mediated disease state, wherein the chemokine binds to an IL-8 &agr; or &bgr; receptor in a mammal, which comprises administering to said mammal an effective amount of a compound of the formula: whereinZ is cyano; R is OH; R1 is independently selected from hydrogen; halogen; nitro; cyano; halosubstituted C1-10 alkyl; C1-10 alkyl; C2-10 alkenyl; C1-10 alkoxy; halosubstituled C1-10 alkoxy; azide; (CR8R8)q S(O)tR4; hydroxy; hydroxy C1-4alkyl; aryl; aryl C1-4 alkyl; aryloxy; aryl C1-4 alkyloxy; aryl C2-10 alkenyl; (CR8R8)qNR4R5; C2-10 alkenyl C(O)NR4R5; (CR8R8)q C(O)NR4R5; (CR8R8)q C(O)NR4R10; S(O)3H; S(O)3R8; (CR8R8)q C(O)R11; C2-10 alkenyl C(O)R11; C2-10 alkenyl C(O)OR11; (CR8R8)q C(O)OR12; (CR8R8)q OC(O)R11; (CR8R8)qNR4C(O)R11; (CR8R8)q NHS(O)2R19; (CR8R8)q S(O)2NR4R5; or a 5 to 6 membered saturated or unsaturated ring, and wherein the aryl moiety may be optionally substituted; m is an integer having a value of 1 to 3; q is 0, or an integer having a value of 1 to 10; s is an integer having a value of 1 to 3; t is 0, or an integer having a value of 1 or 2; v is 0, or an integer having a value of 1 to 4; R4 and R5 are independently hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, or optionally substituted aryl C1-4alkyl; HET is a six-membered ring with one nitrogen atom; R6 and R7 are independently hydrogen or a C1-4 alkyl group; R8 is independently selected from hydrogen or C1-4 alkyl; R10 is C1-10 alkyl C(O)2R8; R11 is hydrogen, C1-4 alkyl, optionally substituted aryl, or optionally substituted aryl C1-4alkyl; R12 is hydrogen, C1-10 alkyl, optionally substituted aryl or optionally substituted arylalkyl; R13 and R14 are independently hydrogen or C1-4 alkyl; R15 and R16 are independently hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, or optionally substituted aryl C1-4alkyl; R17 is C1-4 alkyl, NR15R16, OR11, optionally substituted aryl, or optionally substituted aryl C1-4alkyl; R18 is optionally substituted C1-4 alkyl, optionally substituted aryl, or optionally substituted aryl C1-4alkyl; R19 is C1-4alkyl, aryl, or aiylalkyl, wherein the all of these moieties may be optionally substituted; Rd is NR6R7, alkyl, arylC1-4 alkyl, arylC2-4 alkenyl, wherein the alkyl, or aryl containing moieities may be optionally substituted; the Eâ€² containing ring is optionally selected from