Patent ID: 6376503
Filing Date: 2002-04-23
Classification: C07D

Abstract:
A compound of the formula: whereinQ is E, G, L and M are each independently selected from hydrogen, C1-8 alkyl, C3-8 cycloalkyl, (CH2)0-4OR15, (CH2)0-4N(R16)2, (CH2)0-4CN, (CH2)0-4CF3, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4SO2R16, or (CH2)0-4SO2N(R16)2; J is selected from hydrogen, C1-8 alkyl, C3-8 cycloalkyl, (CH2)1-4OR15, (CH2)1-4N(R16)2, (CH2)1-4CN, (CH2)0-4CF3, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4SO2R16, or (CH2)0-4SO2N(R16)2; R1 is selected from unsubstituted, mono- or poly-substituted phenyl wherein the substituents on the phenyl are independently selected from halogen, CF3, cyano, nitro, N(R16)2, NR16COR18, NR16COR20, NR16CON(R18)2, NR16CONR16CON(R18)2, NR16SO2R18, NR16SO2N(R18)2, OR15, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4SO2N(R16)2, (CH2)0-4SO2R15, (CH2)0-4SO2R22 or C1-4 alkyl; or unsubstituted, mono- or poly-substituted pyridyl, pyrazinyl, pyrimidinyl, thienyl, thiazolyl, furanyl, isoquinolinyl, quinazolinyl or naphthyl wherein the substituents on the pyridyl, pyrazinyl, pyrimidinyl, thienyl,thiazolyl, furanyl, isoquinolinyl, quinazolinyl or naphthyl are independently selected from CF3, cyano, nitro, amino, NR16COR18, NR16COR20, NR16SO2R18, NR16CONR16CON(R18)2, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4SO2N(R16)2, (CH2)0-4SO2R15, (CH2)0-4SO2R22, phenyl OR15, halogen, C1-4 alkyl or C3-8 cycloalkyl; R2 and R7 are each independently selected from hydrogen, C1-8 alkyl, C4-8 cycloalkyl, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4COR16, (CH2)2-4OR15, (CH2)1-4CF3, (CH2)0-4SO2R16, (CH2)0-4SO2N(R16)2 or (CH2)1-4CN; R3 and R6 are each independently selected from hydrogen, C1-8 alkyl, C3-8 cycloalkyl, (CH2)2-4OR15 or (CH2)0-4CF3; R4 is selected from hydrogen, (CH2)0-4COR15, (CH2)0-4CN, (CH2)0-4CF3, (CH2)0-4CO2R16, (CH2)0-4CON(R16)2, (CH2)0-4SO2R15 or (CH2)0-4SO2N(R16)2; R5 is selected from hydrogen, C1-8 alkyl, C3-8 cycloalkyl, (CH2)1-4OR15 or (CH2)0-4CF3; R15 is selected from hydrogen, C1-8 alkyl, C3-8 cycloalkyl or (CH2)0-4CF3; R16 and R18 are each independently selected from hydrogen, C1-8 alkyl, C4-8 cycloalkyl or (CH2)1-4CF3; R20 is furanyl or C1-8 alkyl furanyl; R22 is piperazinyl or C1-8 alkylpiperazinyl; each X is independently selected from halogen, cyano, nitro, C1-8 alkyl, C3-8 cycloalkyl, (CH2)0-4OR15 or (CH2)0-4CF3; q is an integer from zero to four; o is an integer from two to five; and r is an integer from zero to one; or a pharmaceutically acceptable salt thereof.