Patent ID: 9067971
Filing Date: 2015-06-30
Classification: A61K,A61M,A61P,C07K

Abstract:
1. A polypeptide having Formula VI (SEQ ID NO: 81): or an amide, an ester or a salt of the polypeptide wherein: X1 is the N-terminus of the polypeptide and is either absent or is selected from pE, R, Isn, Q, A, K, and 5-amino-valeric acid; X2 is R, A, r, N-Me-R, K, H, hF, hK, F, E or Orn; X4 is R, A, r, N-Me-R, F, E; X5 is L, Cha, A, D-L, N-Me-L, K, D, 4-PhF or F; X8 is K, k, F, f, A, hF, N-Me-R, E or 4-amino-Isn; X9 is G, N-Me-G, A, D, L, R or Aib; X10 is P, A, p, 4-PhP or pipecolic acid, X11 is M, D-Nle, Nle, N-Me-Nle, M(O), A, F, Y, L, K, 3-PyA or Cha; and X13 is the C-terminus and is absent or is selected from F, f, N-Me-F, Nal, D-Nal, 3-Br-F, (S)-β-3-F, I, A, a, K, Dap, H and E; wherein: Nle is L-norleucine; hF is L-homophenylalanine; hK is L-lysine; Nal is L-naphathaline; Orn is ornithine; Aib is α-aminoisobutyric acid; Dab is (S)-diaminobutyric acid; Dap is (S)-2,3-diaminopropionic acid; M(O) is methionine sulfone; Cha is (S)-β-cyclohexylalanine; 4-amino-Isn is 4-aminopiperidine-4-carboxylic acid; Isn is isonipecotinoyl; pE is L-pyroglutamic acid; 3-PyA is 3-(3-pyridyl)-L-alanine; 4-PhF is 4-Phenyl-L-phenylalanine; wherein the N-terminus and the C-terminus optionally form a ring together with 1, 2, 3 or 4 glycine amino acids; and wherein the amino group in the side chain of K, Orn, Dab, Dap, hK or 4-amino-Isn is optionally linked to a lipophilic group via an amide bond.