Patent ID: 8192738
Filing Date: 2012-06-05
Classification: A61K,A61P,C07H,C07K

Abstract:
1. An isolated antibody or binding fragment thereof that specifically binds to Delta-like ligand 4 (DLL4), wherein the antibody or binding fragment comprises: (a) a variable heavy (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of NYGIT (amino acid residues 31-35 of SEQ ID NO:30), a VH CDR2 comprising the amino acid sequence of WISAYNGNTNYAQKLQD (amino acid residues 50-66 of SEQ ID NO:30), and a VH CDR3 comprising the amino acid sequence of DRVPRIPVTTEAFDI (amino acid residues 99-113 of SEQ ID NO:30); and (b) a variable light (VL) CDR1 comprising the amino acid sequence of SGSSSNIGSYFVY (amino acid residues 23-35 of SEQ ID NO:32), a VL CDR2 comprising the amino acid sequence of RNNQRPS (amino acid residues 51-57 of SEQ ID NO:32), and a VL CDR3 comprising the amino acid sequence of AAWDDSLSGHWV (amino acid residues 90-101 of SEQ ID NO:32).