Patent ID: 8293900
Filing Date: 2012-10-23
Classification: A61P,C07D

Abstract:
1. A compound of structural formula IIIa or IIIb of the indicated trans relative stereochemical configuration: or a pharmaceutically acceptable salt thereof; wherein X is oxygen or CH Y is C(R Z is independently selected from the group consisting of: provided that when Z is N, R R wherein heteroaryl is unsubstituted or substituted with one to three groups independently selected from R R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C R wherein alkyl is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C each R wherein alkyl, phenyl, heteroaryl, heterocycloalkyl, naphthyl, cycloalkyl, bicycloalkyl and (CH each R wherein heteroaryl is unsubstituted or substituted with one to three groups independently selected from R each R wherein phenyl, naphthyl, and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R each R wherein phenyl is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C each R r is 2; s is 1; n is 0, 1, 2, or 3; and p is 0, 1, or 2.