Patent ID: 7393548
Filing Date: 2008-07-01
Classification: A61K,A61Q,B82Y

Abstract:
1. A method for facilitating stratum corneum and dermal penetration of at least one bioactive agent having at least one hydrophobic moiety, the method comprising administering a topical cosmetic or pharmaceutical composition in the form of an oil-in-glycerin emulsion to a subject in need or desirous thereof, wherein said topical cosmetic or pharmaceutical composition comprises: a continuous glycerin phase, wherein the continuous glycerin phase comprises at least 50% glycerin; at least one oil comprising an internal phase, wherein the oil is present in an amount ranging from about 0.1-40 wt/wt %; at least one emulsifying stabilizer, selected from the group consisting of saccharide esters or ethers, alkyl glucoside, sucrose esters, and sorbitan esters, wherein the emulsifying stabilizer is present in an amount ranging from about 0.1-10 wt/wt %; and the at least one bioactive agent comprising at least one hydrophobic moiety within its structure, wherein the at least one bioactive agent is present in an amount ranging from about 0.1-20 wt/wt %; wherein the emulsion has a mean droplet size below one micron; and said topical cosmetic or pharmaceutical composition facilitates stratum-corneum and dermal penetration of said at least one bioactive agent.