Patent ID: 7534423
Filing Date: 2009-05-19
Classification: A61K,A61P

Abstract:
1. A method of controlling the extent of inflammation in an individual in vivo via CD73-dependent adenosine production, which comprises administering to said individual (1) a cytokine selected from the group consisting of interferon alpha, interferon beta and interferon gamma in an amount effective to induce endothelial CD73 expression and (2) an agent in an amount effective for maintaining adenosine levels in said individual, wherein said agent is selected from the group consisting of (i) adenosine monophosphate (AMP), (ii) an adenylate kinase inhibitor which prevents AMP from conversion into adenosine diphosphate (ADP) or adenosine triphosphate (ATP) and (iii) an adenosine deaminase inhibitor which prevents the decomposition of adenosine.