Patent ID: 8900567
Filing Date: 2014-12-02
Classification: A61K,A61P,C12N

Abstract:
1. A method of preserving cone cells in a diseased eye of a mammal suffering from a retinal degenerative disease comprising isolating from the bone marrow of the mammal a lineage negative hematopoietic stem cell population that includes endothelial progenitor cells, transfecting cells from the stem cell population with a gene that encodes an antiangiogenic fragment of human tryptophanyl tRNA synthetase (TrpRS), and subsequently intravitreally injecting the transfected cells into the diseased eye in an amount sufficient to inhibit the degeneration of cone cells in the retina of the diseased eye; wherein at least about 50% of the total cells of the stem cell population express CD31, at least about 50% of the total cells of the stem cell population express CD117, and not more than about 1 percent of the total cells of the stem cell population express Tie-2.