Patent ID: 8530181
Filing Date: 2013-09-10
Classification: C12Q,G01N

Abstract:
1. A method of screening for candidate compounds which affect cleavage of EphA7 by γ-secretase, comprising the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition that contains EphA7 in the presence of a candidate compound, and separately contacting said first biological composition with said second biological composition in the absence of the candidate compound, to allow EphA7 to be cleaved; (ii) measuring the cleavage of the EphA7 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA7 by γ-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA7 by γ-secretase.