Patent ID: 7625696
Filing Date: 2009-12-01
Classification: A61K,A61P,G01N

Abstract:
1. A method of screening a compound that changes the binding properties of a protein comprising the amino acid sequence of SEQ ID NO:1 or 2 to a ligand capable of binding specifically to the protein, comprising: (a) contacting the ligand with the protein, and measuring the binding amount of the ligand bound to the protein; (b) contacting the ligand and a test compound with the protein, and measuring the binding amount of the ligand bound to the protein; and (c) comparing the amount in (a) with the amount in (b), wherein said ligand is a compound represented by the formula below: wherein R is hydroxymethyl, formyl or 4-hydroxyphenylcarbamoyl, and wherein the ligand is all trans-retinol, all trans-retinal or 4-hydroxyphenylretinamide.