Patent ID: 6827934
Filing Date: 2004-12-07
Classification: A61K,C07K

Abstract:
A method of inhibiting the interaction of a first cell bearing a B7-2 receptor with a second cell bearing B7-2, comprising contacting said second cell with an effective amount of a humanized immunoglobulin having binding specificity for B7-2, said immunoglobulin comprising:a) at least one antigen binding region of nonhuman origin and b) a portion of an immunoglobulin heavy chain of human origin derived from the III2R (SEQ ID NOS: 25, 29) variable region and a portion of an immunoglobulin light chain of human origin derived from the H2F (SEQ ID NOS: 26, 30) variable region, wherein humanized immunoglobulin has a binding affinity of at least about 107 Mâˆ’1.