Patent ID: 6518287
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound, or an enantiomer, a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt or solvate of said compound, with said compound having the general structure shown in Formula I: whereinG is selected from the group consisting of C1-C6 alkyl or a bond; M is a moiety selected from the group consisting of â€”C&boxH;Câ€”, â€”Câ‰¡Câ€”, â€”C(&boxH;NR7)â€”NR6â€”, â€”NR6â€”C(&boxH;NR7)â€”, â€”NR6â€”C(O)â€”NR6â€”, â€”NR6â€”C(O)â€”Oâ€”, â€”Oâ€”C(O)â€”NR6â€”, â€”NR6â€”C(O)â€”, â€”C(O)â€”NR6â€”, â€”Oâ€”, â€”NR6â€”, â€”C(O)â€”, â€”N+R6R8â€”, and p is 1-6 V is C1-C6 alkyl; X and Y may be the same or different and are independently selected from the group consisting of N, CH, or N-oxide, with the proviso that at least one of X and Y is N or N-oxide; R1 and R2 may each number 1-4 and are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, polyhalolower alkyl, â€”OH, â€”N(R6)2, â€”NO2, â€”CN, â€”COOR6, â€”CONR6R8, and â€”NR6â€”C(O)â€”R7(wherein R7 is not â€”OH or â€”CN); R3 is selected from hydrogen, lower alkyl, lower alkoxy, hydroxyl, polyhalolower alkyl, and a bond forming a double bond towards the moiety G when G is C1-C6 alkyl; R4 and R5 are independently selected from the group consisting of hydrogen, lower alkyl, and polyhalolower alkyl; R6 and R8 are independently selected from hydrogen, lower alkyl, aralkyl, alkylaryl, polyhalolower alkyl, substituted or unsubstituted phenyl; and substituted or unsubstituted benzyl; and R7 is selected from H, OH, alkoxy, cyano, phenyl, substituted phenyl, benzyl, and substituted benzyl; with the proviso that when G is a bond, M is not â€”NR6C(O)Oâ€”, and with the proviso that when G is a bond and when M is either â€”Oâ€” or â€”Oâ€”C(O)â€”NR6â€”, then one of X and Y is N; and with the further proviso that when R3 is â€”OH or alkoxyl, and G is a bond, then Mâ‰ O or NR6.