Patent ID: 6620815
Filing Date: 2003-09-16
Classification: A61K,C07D

Abstract:
A compound having the structure: wherein each X is independently O or S; wherein each R2 is independently H; â€”(CH2)tXR3; â€”(CH2)tCO2R3; â€”CO2R3; straight chained or branched C1-C7 alkyl, aminoalkyl, carboxamidoalkyl; straight chained or branched C2-C7 alkenyl, or alkynyl; or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; wherein each t is an integer from 1 to 4 inclusive; wherein each R3 is independently H; straight chained or branched C1-C7 alkyl, straight chained or branched C2-C7 alkenyl, or alkynyl; or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; wherein R4 is aryl, heteroaryl, C1-C7 alkyl substituted with one or two aryl, or C1-C7 alkyl substituted with one or two heteroaryl; wherein the aryl or heteroaryl may be substituted with one or more of F, Cl, Br, I, â€”CN, â€”NO2, â€”N(R3)2, â€”COR3, â€”(CH2)tXR3, â€”(CH2)nCO2R3, straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl or carboxamidoalkyl, or straight chained or branched C2-C7 aminoalkyl, alkenyl or alkynyl, or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; wherein each n independently is an integer from 0 to 7 inclusive; wherein R5 is H; aryl, C1-C7 alkyl substituted with aryl, heteroaryl, or C1-C7 alkyl substituted with heteroaryl; wherein the aryl or heteroaryl may be substituted with one or more of F, Cl, Br, I, â€”CN, â€”NO2, â€”N(R3)2, â€”COR3, â€”(CH2)tXR3, â€”(CH2)nCO2R3, straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl or carboxamidoalkyl, or straight chained or branched C2-C7 aminoalkyl, alkenyl or alkynyl, or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; where R5 and one R2 on adjacent carbon atoms together may form aryl, heteroaryl, indane or tetrahydronaphthyl, C3-C7 cycloalkyl, or heterocycloalkyl wherein one or two heteroatoms may be O, N or S; wherein R1 is where each R6 is independently aryl or heteroaryl, wherein the aryl or heteroaryl may be substituted with one or more of F, Cl, Br, I, â€”(CH2)nXR3, â€”COR3, â€”(CH2)nC(X)N(R3)2, â€”(CH2)nCO2R3, â€”CN, â€”NO2, â€”N(R3)2, â€”SO2R3, straight chained or branched C1-C7 alkyl, monofluoroalkyl or polyfluoroalkyl, straight chained or branched C2-C7 alkenyl or alkynyl, or C3-C7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or C5-C7 cycloalkenyl; where each R7 is independently H; F; Cl; Br; I; â€”COR3; â€”CO2R3; â€”(CH2)nXR3; â€”(CH2)nC(X)N(R3)2; â€”(CH2)nCO2R3; â€”CN; â€”NO2; â€”N(R3)2; straight chained or branched C1-C7 alkyl, hydroxyalkyl, aminoalkyl, carboxamidoalkyl, alkoxyalkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C2-C7 alkenyl or alkynyl; C3-C7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or C5-C7 cycloalkenyl, wherein the alkyl, aminoalkyl, carboxamidoalkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl may be substituted with one or more aryl or heteroaryl, wherein the aryl or heteroaryl may be substituted with one or more of F, Cl, Br, I, â€”(CH2)nXR3â€”COR3, â€”(CH2)nC(X)N(R3)2, â€”(CH2)nCO2R3, â€”CN, â€”NO2, â€”N(R3)2, â€”SO2R3, straight chained or branched C1-C7 alkyl, monofluoroalkyl or polyfluoroalkyl, straight chained or branched C2-C7 alkenyl or alkynyl, or C3-C7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or C5-C7 cycloalkenyl; aryl or heteroaryl, wherein the aryl or heteroaryl may be substituted with one or more of F, Cl, Br, I, â€”(CH2)nXR3, â€”COR3, â€”(CH2)nC(X)N(R3)2, â€”(CH2)nCO2R3, â€”CN, â€”NO2, â€”N(R3)2, â€”SO2R3, straight chained or branched C1-C7 alkyl, straight chained or branched C1-C7 monofluoroalkyl or polyfluoroalkyl, straight chained or branched C2-C7 alkenyl or alkynyl, or C3-C7 cycloalkyl, monofluorocycloalkyl, polyfluorocycloalkyl or C5-C7 cycloalkenyl; wherein each R10 is independently H; â€”(CH2)tXR3; â€”(CH2)tCO2R3; straight chained or branched C1-C7 alkyl or carboxamidoalkyl; straight chained or branched C2-C7 aminoalkyl, alkenyl, or alkynyl; or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; wherein R11 is substituted aryl, heteroaryl, C1-C7 alkyl substituted with one or two aryl, or C1-C7 alkyl substituted with one or two heteroaryl; wherein any substituted aryl independently is or any heteroaryl independently may be substituted with one or more of F, Cl, Br, I, â€”CN, â€”NO2, â€”N(R3)2, â€”COR3, â€”(CH2)nSR3, â€”(CH2)nOR3 wherein R3 is straight chained C1-C7 alkyl, â€”(CH2)nC(X)N(R3)2, â€”(CH2)nCO2R3, straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, or carboxamidoalkyl, straight chained or branched C2-C7 aminoalkyl, alkenyl, or alkynyl, or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; wherein each m independently is an integer from 0 to 3 inclusive; wherein Z is â€ƒor C2-C7 alkenyl, wherein the C2-C7 alkenyl may be unsubstituted or substituted with one or more R9 groups; where R8 is H; â€”(CH2)tXR3; â€”(CH2)tCO2R3; straight chained or branched C1-C7 alkyl, carboxamidoalkyl; straight chained or branched C2-C7 aminoalkyl, alkenyl, or alkynyl; or C3-C7 cycloalkyl or C5-C7 cycloalkenyl; where each R9 is independently H; F; Cl; Br; I; â€”(CH2)mXR3; â€”(CH2)mCO2R3; straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, or carboxamidoalkyl; straight chained or branched C2-C7 alkenyl, or alkynyl; or C3-C7 cycloalkyl or C1-C7 cycloalkenyl; wherein Y is S, O, or NR8; or a pharmaceutically acceptable salt thereof.