Patent ID: 6670393
Filing Date: 2003-12-30
Classification: A61K,C07C,C07J,C07K

Abstract:
A lipid having the structure: or a salt, or solvate, or enantiomers thereof wherein: (a) R1 is a lipophilic moiety selected from the group consisting of a straight chain alkyl of 5 to about 24 carbon atoms, a straight chain alkenyl of 2 to about 24 carbon atoms, a symmetrical branched alkyl or alkenyl of about 10 to about 50 carbon atoms, a unsymmetrical branched alkyl or alkenyl of about 10 to about 50 carbon atoms, and CH(R3R4), wherein R3 and R4 are independently a straight chain alkyl moiety of about 10 to about 30 carbon atoms, or a branched alkyl moiety of 3 to about 30 carbon atoms; (b) R2 is selected from the group consisting of an amino acid residue having a positively charged group on the side chain, an alkylamine moiety of 3 to 10 carbon atoms, fluoroalkylamine moiety or a perfluoroalkylamine moiety of 1 to 6 carbon atoms, anarylamine moiety or an aralkylamine moiety of 5 to 10 carbon atoms, a guanidinium moiety, an enamine moiety, an aromatic or non-aromatic cyclic amine moiety of 3 to about 9 carbon atoms, an amidine moiety, an isothiourea moiety, a heterocyclic amine moiety, a heterocyclic moiety and an alkyl moiety of 1 to 6 carbon atoms substituted with a substituent selected from the group consisting of NH2, C(&boxH;O)NH2, NHR6, C(&boxH;O)NHR6, NHR6R7, or C(&boxH;O)NHR6R7, wherein R6 and R7 are independently selected from an alkyl moiety of 1 to 24 carbon atoms, an alkenyl moiety of 2 to 24 carbon atoms, an aryl moiety of 5 to 20 carbon atoms and an aralkyl moiety of 6 to 25 carbon atoms; (c) n is an integer from 1 to 8; (d) X is an anion or polyanion; and (e) m is a integer from 0 to a number equivalent to the positive charge(s present on the lipid.