Patent ID: 6254870
Filing Date: 2001-07-03
Classification: A61K,A61P,C07K

Abstract:
A chimera protein comprising the sequence(SEQ ID NO:44) Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 1 5 10 Val Leu Ser Lys Leu Leu Arg Asp Ser His 15 20 Val Leu His Ser Arg Leu Ser Gln Cys Pro 25 30 Glu Val His Pro Leu Pro Thr Pro Val Leu 35 40 Leu Pro Ala Val Asp Phe Ser Leu Gly Glu 45 50 Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 55 60 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu 65 70 Leu Glu Gly Val Met Ala Ala Arg Gly Gln 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 85 90 Gly Gln Leu Ser Gly Gln Val Arg Leu Leu 95 100 Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr 105 110 Gln Gly Arg Thr Thr Ala His Lys Asp Pro 115 120 Asn Ala Ile Phe Leu Ser Phe Gln His Leu 125 130 Leu Arg Gly Lys Val Arg Phe Leu Met Leu 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu 145 150 Phe His Ala Tyr Val Glu Gly Gly Gly Gly 155 160 Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 165 170 Asn Met Ala Asn Cys Ser Ile Met Ile Asp 175 180 Glu Ile Ile His His Leu Lys Arg Pro Pro 185 190 Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn 195 200 Ser Glu Asp Met Asp Ile Leu Met Glu Arg 205 210 Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 215 220 Val Arg Ala Val Lys His Leu Glu Asn Ala 225 230 Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu 235 240 Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala 245 250 Pro Ser Arg His Pro Ile Ile Ile Lys Ala 255 260 Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu 265 270 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala 275 280 Gln Glu Gln Gln;and said chimera protein is optionally immediately preceded by Met.sup.-1, Ala.sup.-1 or Met.sup.-2 Ala.sup.-1.