Patent ID: 6028224
Filing Date: 2000-02-22
Classification: C07B,C07C

Abstract:
A process for preparing 3-(methylamino)-1-phenylpropanol comprising the steps of:(a) reacting 5-phenyltetrahydrofuran-2-one with an excess of ammonia to provide 4-hydroxybenzenebutanamide;(b) reacting said 4-hydroxybenzenebutanamide with an oxidant to provide 6-phenyltetrahydrooxazin-2-one;(c) reacting said 6-phenyltetrahydrooxazin-2-one with a strong base followed by a methylating agent to provide 3-methyl-6-phenyltetrahydrooxazin-2-one; and(d) hydrolyzing said 3-methyl-6-phenyltetrahydrooxazin-2-one to provide 3-(methylamino)-1-phenylpropanol.