Patent ID: 6515122
Filing Date: 2003-02-04
Classification: C07D

Abstract:
A single compound of the formula: wherein:R1 is selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, phenyl, substituted phenyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, cyano, C1 to C12 acyl, C1 to C12 substituted acyl, C1 to C12 alkoxycarbonyl, C1 to C12 substituted alkoxycarbonyl, C1 to C12 alkylaminocarbonyl, C1 to C12 substituted alkylaminocarbonyl, phenylaminocarbonyl, substituted phenylaminocarbonyl, C1 to C10 alkylthio, C1 to C10 substituted alkylthio, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C10 alkylsulfoxide, C1 to C10 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl, substituted phenylsulfonyl, heterocycle, substituted heterocycle, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, naphthyl, substituted naphthyl, C5 to C7 cycloalkyl, C5 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl and C5 to C7 substituted cycloalkenyl; R2, R3, R5, R6, R8 and R9 are, independently, selected from the group consisting of a hydrogen atom, halo, hydroxy, protected hydroxy, cyano, C1 to C12 alkyl, C2 to C12 alkenyl, C2 to C12 alkynyl, C1 to C12 substituted alkyl, C2 to C12 substituted alkenyl, C2 to C12 substituted alkynyl, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, C1 to C12 acyloxy, C1 to C12 acyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, heterocyclic ring, substituted heterocyclic ring, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, C1 to C10 alkylamino, C1 to C10 alkyl protected amino, C1 to C10 alkyl (monosubstituted)amino, C1 to C10 alkyl, protected (monosubstituted)amino, C1 to C10 alkyl(disubstituted)amino, C1 to C10 substituted alkylamino, C1 to C10 substituted alkyl protected amino, C1 to C10 substituted alkyl (monosubstituted)amino, C1 to C10 substituted alkyl protected (monosubstituted)amino, C1 to C10 substituted alkyl(disubstituted)amino, carboxamide, protected carboxamide, C1 to C10 alkylthio, C1 to C10 substituted alkylthio, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C10 alkylsulfoxide, C1 to C10 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl, substituted phenylsulfonyl and and the group consisting of (i) the formula â€”C(O)NR11R12, (i) the formula â€”C(O)R11, (iii) the formula â€”NR11R12, (iv) the formula â€”SR11, (v) the formula â€”OR11 and (vi) the formula â€”C(O)OR11, wherein R11 and R12 are, independently, selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, C1 to C12 acyl, C1 to C12 substituted acyl, phenylsulfonyl, substituted phenylsulfonyl, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C12 alkylaminocarbonyl, C1 to C12 substituted alkylaminocarbonyl, phenylaminocarbonyl, and substituted phenylaminocarbonyl, or, in the formula â€”C(O)NR11R12, R11 and R12 join the nitrogen atom in the formula to form a heterocycle or substituted heterocycle; R4 is selected from the group consisting of halo, hydroxy, protected hydroxy, cyano, C1 to C12 alkyl, C2 to C12 alkenyl, C2 to C12 alkynyl, C1 to C12 substituted alkyl, C2 to C12 substituted alkenyl, C2 to C12 substituted alkynyl, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, C1 to C12 acyloxy, C1 to C12 acyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, heterocyclic ring, substituted heterocyclic ring, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, C1 to C10 alkylamino, C1 to C10 alkyl protected amino, C1 to C10 alkyl (monosubstituted)amino, C1 to C10 alkyl, protected (monosubstituted)amino, C1 to C10 alkyl(disubstituted)amino, C1 to C10 substituted alkylamino, C1 to C10 substituted alkyl protected amino, C1 to C10 substituted alkyl (monosubstituted)amino, C1 to C10 substituted alkyl protected (monosubstituted)amino, C1 to C10 substituted alkyl(disubstituted)amino, carboxamide, protected carboxamide, C1 to C10 alkylthio, C1 to C10 substituted alkylthio, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C10 alkylsulfoxide, C1 to C10 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl, substituted phenylsulfonyl and and the group consisting of (i) the formula â€”C(O)NR11R12, (i) the formula â€”C(O)R11, (iii) the formula â€”NR11R12, (iv) the formula â€”SR11, (v) the formula â€”OR11 and (vi) the formula â€”C(O)OR11, wherein R11 and R12 are, independently, selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, C1 to C12 acyl, C1 to C12 substituted acyl, phenylsulfonyl, substituted phenylsulfonyl, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C12 alkylaminocarbonyl, C1 to C12 substituted alkylaminocarbonyl, phenylaminocarbonyl, and substituted phenylaminocarbonyl, or, in the formula â€”C(O)NR11R12, R11 and R12 join the nitrogen atom in the formula to form a heterocycle or substituted heterocycle; R7 is selected from the group consisting of a halo, hydroxy, protected hydroxy, cyano, C1 to C12 alkyl, C2 to C12 alkenyl, C2 to C12 alkynyl, C1 to C12 substituted alkyl, C2 to C12 substituted alkenyl, C2 to C12 substituted alkynyl, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, C1 to C12 acyloxy, C1 to C12 acyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, heterocyclic ring, substituted heterocyclic ring, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, cyclic C2 to C7 alkylene, substituted cyclic C2 to C7 alkylene, cyclic C2 to C7 heteroalkylene, substituted cyclic C2 to C7 heteroalkylene, carboxy, protected carboxy, hydroxymethyl, protected hydroxymethyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino, (disubstituted)amino, C1 to C10 alkylamino, C1 to C10 alkyl protected amino, C1 to C10 alkyl (monosubstituted)amino, C1 to C10 alkyl, protected (monosubstituted)amino, C1 to C10 alkyl(disubstituted)amino, C1 to C10 substituted alkylamino, C1 to C10 substituted alkyl protected amino, C1 to C10 substituted alkyl (monosubstituted)amino, C1 to C10 substituted alkyl protected (monosubstituted)amino, C1 to C10 substituted alkyl(disubstituted)amino, carboxamide, protected carboxamide, C1 to C10 alkylthio, C1 to C10 substituted alkylthio, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C10 alkylsulfoxide, C1 to C10 substituted alkylsulfoxide, phenylthio, substituted phenylthio, phenylsulfoxide, substituted phenylsulfoxide, phenylsulfonyl, substituted phenylsulfonyl and and the group consisting of (i) the formula â€”C(O)NR11R12, (i) the formula â€”C(O)R11, (iii) the formula â€”NR11R12, (iv) the formula â€”SR11, (v) the formula â€”OR11, and (vi) the formula â€”C(O)OR11, wherein R11 and R12 are, independently, selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl, C1 to C12 substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, C1 to C12 acyl, C1 to C12 substituted acyl, phenylsulfonyl, substituted phenylsulfonyl, C1 to C10 alkylsulfonyl, C1 to C10 substituted alkylsulfonyl, C1 to C12 alkylaminocarbonyl, C1 to C12 substituted alkylaminocarbonyl, phenylaminocarbonyl, and substituted phenylaminocarbonyl; and R10 is selected from the group consisting of a hydrogen atom, C1 to C12 alkyl, C1 to C12 substituted alkyl, C2 to C12 alkenyl, C2 to C12 substituted alkenyl, C7 to C18 phenylalkyl, C7 to C18 substituted phenylalkyl, C1 to C12 heterocycloalkyl and C1 to C12 substituted heterocycloalkyl; or a pharmaceutically acceptable salt of a compound thereof.