Patent ID: 6723831
Filing Date: 2004-04-20
Classification: A61K,A61P,B01J,C07K

Abstract:
A polyamide conjugate comprising either (a) an oligosaccharide terminating with an alpha-linked D-galactopyranose or N-glycol-neuraminic acid at its reducing end; or (b) cellulose, agarose, or sepharose, bound to a linear polyamide backbone, wherein the polyamide backbone comprises at least one structural element of formula I and in case (b) additionally at least one structural element of formula II whereineach of A and Aâ€², independently, is a trivalent bridging group; each of R1 and R1, independently, is a direct bond or C1-C6 alkylene; each of X1 and X1, independently, is â€”C(O)Oâ€”, â€”C(O)NRâ€”, â€”NRâ€”, â€”Sâ€”, or â€”Oâ€”. each of R2 and R2, independently, is a direct bond or a bivalent bridging group; each of X2 and X2â€², independently, is a direct bond or â€”Oâ€” or â€”NRâ€”; wherein R is hydrogen, OH, C1-C12alkyl, C2-C12alkenyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, C2-C7heterocycloalkyl, C2-C11heterocycloalkenyl, C6 or C10aryl, C5-C9heteroaryl, C7-C16aralkyl, C8-C16aralkenyl with C2-C6alkenylene and C6 or C10aryl, or di-C6 or C10aryl-C1-C6-alkyl; and each of Y and Yâ€², independently, is a direct bond or a bivalent bridging group; with the proviso that X1 or X1â€², is not â€”NRâ€”, â€”Sâ€” or â€”Oâ€” when R1 or R1â€² is a direct bond.