Patent ID: 6187936
Filing Date: 2001-02-13
Classification: C12P

Abstract:
A process for the preparation of: ##STR8##which comprises the enzymatic kinetic resolution of trans 3-phenylglycidates of formula: ##STR9##whereinR is linear or branched C.sub.1 -C.sub.4 alkyl;R.sub.1 is hydrogen, linear or branched C.sub.1 -C.sub.3 alkyl, linear or branched C.sub.1 -C.sub.3 alkoxy, aryl or halogen;by transesterification of the mixture of trans enantiomers of formula I catalysed by enzymes in organic solvent with aminoalcohols of formula: ##STR10##whereinn is an integer from 2 to 4;R.sub.2 is hydrogen or linear or branched C.sub.1 -C.sub.4 alkyl;R.sub.3 is linear or branched C.sub.1 -C.sub.4 alkyl; orR.sub.2 and R.sub.3 together with the nitrogen atom form a 5 to 7 membered saturated cycle;to give a mixture of trans esters, non transesterified and transesterified, having an opposite absolute configuration, of formula III and IV respectively: ##STR11##wherein R, R.sub.1, R.sub.2, R.sub.3 and n have the above reported meanings,and the subsequent separation of such a mixture of esters of formula III and IV.