Patent ID: 8187584
Filing Date: 2012-05-29
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A human tumor necrosis factor-alpha mutant protein, which specifically binds to both a TNF receptor having a molecular weight of 55 kilo daltons (TNF-R1) and a TNF receptor having a molecular weight of 75 kilo daltons (TNF-R2), and which has a higher binding affinity for said TNF-R1 or for said TNF-R2, wherein four or more amino acid residues selected from the group consisting of the 29th, 31st, 32nd, 84th to 89th, 145th, 146th and 147th amino acid residues of the amino acid sequence of SEQ ID NO:1 are replaced with other amino acid(s).