Patent ID: 8299293
Filing Date: 2012-10-30
Classification: C07B,C07C,C07D

Abstract:
1. A method, comprising: a) reacting an aldehyde represented by R b) reacting the dithioacetal with a carbonyl-containing electrophile in the presence of a strong base that comprises at least one member selected from the group consisting of n-butyllithium, tert-butyllithium, sodium amide, sodium hydride, potassium hydroxide, and potassium carbonate and hydrolyzing in a solvent represented by R c) converting the α,α-(dithio)carboxylic acid or derivative thereof represented by formula (III) by acid-catalyzed solvolysis in the presence of at least one molar equivalent of water with release of thiols of the formula R wherein R R R R R a diol represented by HO—R a triol represented by HOR an amine represented by HNR wherein R with the proviso that R