Patent ID: 6190692
Filing Date: 2001-02-20
Classification: A61K

Abstract:
A method for time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of said pharmaceutically active agent, said method comprising administering to said patient, a pharmaceutical formulation comprising:(a) a core which comprises a capsule containing a liquid form of said pharmaceutically active agent, and(b) a swellable polymeric coating layer substantially surrounding said core, that delays the release of said pharmaceutically active agent from said core for a predetermined period of time dependent upon the thickness of said swellable polymeric coating layer; and wherein said swellable polymeric coating layer is provided by alternately (I) wetting said core with a binder solution, and (ii) coating said core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.