Patent ID: 8538520
Filing Date: 2013-09-17
Classification: A61K,A61N

Abstract:
1. A method for cardiac protection, the method comprising: sensing one or more parameters indicative of an ischemic event in a mammal using an implantable medical device; detecting the ischemic event from the one or more parameters, including detecting an end of the ischemic event, using the implantable medical device; initiating one or more cardiac protection biologic therapies using the implantable medical device in response to the detection of the ischemic event, the one or more cardiac protection biologic therapies each including at least one signaling and non-signaling period, the at least one signaling period having a signaling duration during which at least one gene regulatory signal is delivered, the at least one non-signaling period having a non-signaling duration during which the at least one gene regulatory signal is not delivered, the at least one gene regulatory signal is capable of directly or indirectly regulating a regulatable transcriptional control element without inducing cardiac depolarization, the regulatable transcriptional control element is operably linked to an open reading frame forming an expression cassette, wherein the expression cassette is present in the mammal, and wherein expression of the open reading frame in an effective amount inhibits damage to tissue in the mammal resulting from ischemia; and delivering the at least one gene regulatory signal from the implantable medical device during at least one of the signaling periods, wherein the one or more cardiac protection biologic therapies include at least one postconditioning cardiac biologic therapy, and initiating the one or more cardiac protection biologic therapies includes initiating the at least one postconditioning cardiac biologic therapy using the implantable medical device when a post-ischemia time interval expires, the post-ischemia time interval starting at the detected end of the ischemic event and ending after a predicted reperfusion period following the ischemic event has started.