Patent ID: 6071532
Filing Date: 2000-06-06
Classification: A61K,B82Y,C07H,C07K,Y10S,Y10T

Abstract:
A glycophospholipid or a peptide-phospholipid conjugate, comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine, said coniugate having the formula ##STR3## which conjugate is the product of the process of (a) coupling of an activated saccharide or peptide with a diol,(b) transformation of the remaining primary hydroxyl group to an aldehyde group,(c) reductive amination of the aldehyde with a phosphatidyl nitrogenous base and(d) removal of any protecting groups on the saccharide or peptide moiety;whereinR.sub.1 and R.sub.2 are independently selected from the group comprising straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl, alkenyl, alkynyl and aryl groups;Y is a cation;X is a secondary or tertiary amine linker, comprising two to twenty carbon atoms, wherein a substituent group of the amine is selected independently from a group comprising a hydrogen, a straight or branched, unsubstituted or substituted alkyl alkenyl, alkynyl and aryl groups; andZ is a saccharide, a peptide or a functionalized derivative thereof.