Patent ID: 6194450
Filing Date: 2001-02-27
Classification: A61K,A61P,A61Q,C07D

Abstract:
A method for treating a keratinization disorder in a mammalian organism in need of such treatment, comprising administering to such organism a therapeutically effective amount of a pharmaceutical composition containing a polyaromatic heterocyclic compound having the structural formula (I): ##STR12##in which Z is --O--; Ar is either a radical having the following structural formula (II): ##STR13##or a radical having the following structural formula (III): ##STR14##wherein m is equal to 0 or 1; R.sub.1 is (i) a hydrogen atom, (ii) the --CH.sub.3 radical, (iii) a radical --(CH.sub.2).sub.p --O--R.sub.12, (iv) a radical --OR.sub.12, (v) a radical: ##STR15##or (vi) a radical --S(O).sub.t R.sub.14, wherein R.sub.12, R.sub.13, R.sub.14, p and t are as defined below; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl radical or a radical --OR.sub.12, wherein R.sub.12 is as defined below; R.sub.3 and R.sub.4, which may be identical or different, are each a halogen atom, a hydrogen atom, a lower alkyl radical or a radical OR.sub.12, wherein R.sub.12 is as defined below; R.sub.5 is a halogen atom, a hydrogen atom, a lower alkyl radical or a radical --OR.sub.15, wherein R.sub.15 is as defined below; R.sub.6, R.sub.7, R.sub.8 and R.sub.9, which may be identical or different, are each a hydrogen atom, a halogen atom, an alkyl radical, a cycloalkyl radical, a radical --(Z.sub.1).sub.n --(CH.sub.2).sub.q --CO--R.sub.13, or a radical --Z.sub.2 --R.sub.12, with the proviso that at least two of the radicals R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are other than a hydrogen atom and further wherein Z.sub.1, Z.sub.2, R.sub.12, R.sub.13, n and q are as defined below; R.sub.10 and R.sub.11 are lower alkyl radicals; Y is a divalent radical selected from among --C(R.sub.11).sub.2 --, --O--, --S--, --CH(OH)--, --CO--, --SO-- and --SO.sub.2 --, wherein R.sub.11 is as defined above, with the proviso that R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 cannot simultaneously each be a hydrogen atom; R.sub.12 is a hydrogen atom, a lower alkyl radical, an aryl radical, an aralkyl radical, a polyhydroxyalkyl radical, a polyether radical or a lower acyl radical; R.sub.13 is (a) a hydrogen atom, (b) a radical: ##STR16##wherein r and r' are as defined below, or (c) a radical --OR.sub.14, wherein R.sub.14 .sub.4 is as defined below; R.sub.14 is a hydrogen atom, an alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or aralkyl radical, or a sugar or amino acid residue; R.sub.15 is a hydrogen atom, a lower alkyl radical, an aryl radical, an aralkyl radical or a polyether radical; r and r', which may be identical or different, are each a hydrogen atom, a lower alkyl radical, an optionally substituted aryl radical, or an amino acid or sugar residue, or r and r' may together form, with the nitrogen atom from which they depend, a heterocycle; Z.sub.1 is O, S or Nr'; Z.sub.2 is O or S, n is equal to 0 or 1; p is equal to 0, 1, 2 or 3; q is an integer ranging from 0 to 10; t is equal to 0, 1, 2 or 3; and the pharmaceutically/cosmetically acceptable optical and geometric isomers and salts thereof, contained in a pharmaceutically acceptable carrier, diluent or vehicle therefor.