Patent ID: 8565862
Filing Date: 2013-10-22
Classification: A61B

Abstract:
1. A method for detecting an abnormality within a tissue said method comprising using a processing unit: obtaining measurements of said tissue using a plurality of optical source-detector pairs; applying a non-linear least square (NNLS) solution of an inverse problem to said measurements to determine optical properties of constituents of said tissue; optically reconstructing a volume of said tissue by synthesizing said measurements through the NNLS solution of the inverse problem; the NNLS solution being derived from the equation: where is the wavelength dependent extinction coefficient of the i-th chromophore and C i its concentration; obtaining a value related to an optical property of said tissue from each of at least two regions of interest (ROIs), wherein said at least two ROIs are contained within said optically reconstructed volume of said tissue; comparing pair-wise said values from said at least two ROIs to generate, for each ROI pair of the at least two ROIs, a ratio of said values, wherein said ratio is indicative of a presence of said abnormality in one of said at least two ROIs.