Patent ID: 6768024
Filing Date: 2004-07-27
Classification: C07C,C07D

Abstract:
A compound of the formula: wherein:the dotted lines indicate that the depicted ring is selected from the group consisting of phenyl and cyclohexyl; n is 0, 1 or 2; R1 to R5 are, independently, selected from the group consisting of a hydrogen atom, halo, hydroxy, protected hydroxy, nitro, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 phenylalkyl, C7 to C12 substituted phenylalkyl, C3 to C7 cycloalkyl, C3 to C7 substituted cycloalkyl, C5 to C7 cycloalkenyl, C5 to C7 substituted cycloalkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1 to C6 alkoxy, C1 to C6 substituted alkoxy, phenoxy, substituted phenoxy, C1 to C6 alkylthio, C1 to C6 substituted alkylthio, C1 to C6 alkylsulfonyl, C1 to C6 substituted alkylsulfonyl, phenylthio, substituted phenylthio, phenylsulfonyl, substituted phenylsulfonyl, amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino and (disubstituted)amino; and when any one of adjacent position pairs R1 and R2, R2 and R3, and R3 and R and R4 and R5 together form a moiety selected from the group consisting of phenyl, substituted phenyl, heterocycle and substituted heterocycle, said moiety fused to the phenyl ring depicted in the above formula such that a bicyclic ring results; R6 is selected from the group consisting of C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 phenylalkyl, C7 to C12 substituted phenylalkyl, C11 to C16 naphthylalkyl and C11 to C16 substituted naphthylalkyl; where R7 is absent, R8 together with the attached nitrogen depicted in the above formula form a substituted heterocycle or a substituted cyclic C3 to C7 heteroalkylene, wherein at least one of said substitution is the formula -D-E, wherein D may be absent or present and, if present, is selected from the group consisting of C1 to C6 alkylene and C1 to C6 substituted alkylene; and E is selected from the group consisting of amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino and (disubstituted)amino group; and where R7 is selected from the group consisting of a hydrogen atom, C1 to C6 alkyl and C1 to C6 substituted alkyl, R8 is the formula Xâ€”CHâ€”Y, wherein the attached nitrogen depicted in the above formula is attached to the carbon atom of the formula Xâ€”CHâ€”Y, and wherein X is selected from the group consisting of a hydrogen atom, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 phenylalkyl, C7 to C12 substituted phenylalkyl, phenyl, substituted phenyl, naphthyl and substituted naphthyl, and Y is the formula â€”(CH2)nâ€”Z, wherein n is 1 to 6 and Z is selected from the group consisting of amino, protected amino, (monosubstituted)amino, protected (monosubstituted)amino and (disubstituted)amino; wherein, when a) the depicted ring is phenyl, and b) R1 to R5 and R7 are each hydrogen and c) R8 is the formula Xâ€”CHâ€”Y, where X is benzyl and Y is â€”CH2-amino, then R6 is not benzyl; or a pharmaceutically-acceptable salt thereof.