Patent ID: 8404852
Filing Date: 2013-03-26
Classification: A61K,A61P,C07D

Abstract:
1. A method of controlling, treating or reducing the advancement, severity or effects of a nosocomial or a non-nosocomial bacterial infection in a patient, wherein the bacterial infection is characterized by the presence of one or more of the following: Isoniazid resistant Mycobacterium or Rifampin resistant Mycobacterium comprising the step of administering to said patient a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is selected from nitrogen, CH, or CF; X is selected from CH or CF; Z is O or NH; R y is 0 or 1; T is a straight or branched C each R′ is independently selected from hydrogen, C Ar is a 3-8 membered saturated, unsaturated, or aryl ring, a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: R Ring A is a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, provided that said ring has a hydrogen-bond acceptor in the position adjacent to the point of attachment to Ring B, wherein: