Patent ID: 6355823
Filing Date: 2002-03-12
Classification: C07F

Abstract:
A compound of formula (I): where:A1 and A2 are the same or different aryl groups collectively bearing at least one hydrophilic substituent; E1 and E2 are the same or different and are O, S, or NR2 (where R2 is H or a linear or branched C1-C20 carbon containing group); M is H or a pharmaceutically acceptable monovalent cation; R1 is a linear or branched, saturated or unsaturated, C1-C20 carbon containing group; Z is a single bond, a carbonyl, CE3E4, or CR3E41, where E3 and E4 are the same or different and are OR4, SR41, and NR42, where R3 is a linear or branched C1-C20 carbon containing group, and R4 is H or a linear or branched C1-C20 carbon containing group; and n is 0 or 1, or a pharmaceutically acceptable salt thereof, provided that, when E1 is O and when Z is a carbonyl and when A1 is a phenyl ring and when E1 is at the 2-position of the phenyl ring A1, A1 is not further substituted in the 4- and 6-positions of the phenyl ring A1 with OR5 groups (where R5 is a carbon containing group having between 1 and 4 carbon atoms); and further provided that the compound is not 4â€²-phosphophloretin or a pharmaceutically acceptable salt thereof.