Patent ID: 7700823
Filing Date: 2010-04-20
Classification: A01K,C12N

Abstract:
1. A transgenic mouse whose genome comprises a homozygous mutation in the endogenous presenilin 1 gene and an insertion of a nucleic acid sequence under the control of an exogenous Thy-1 promoter encoding a mutant Aβ peptide precursor protein (APP), wherein the amino acid sequence encoded by the presenilin 1 gene consists of the following two mutations a threonine residue at position 233 and a proline residue at position 235 of the murine presenilin 1 protein as set forth in SEQ ID No: 3; wherein the amino acid sequence encoding the mutation in the human Aβ peptide precursor comprises human APP751 having Swedish (K670N/M671 L) and London (V7171) mutations; and wherein the transgenic mouse exhibits elevated Aβ protein levels, elevated Aβ 42levels, an Aβ 42 to total Aβ ratio greater than about 0.9, increased density of Aβ deposits, increased size of Aβ deposits, increased distribution of Aβ deposits, loss of neuronal cells and loss of glial cells.