Patent ID: 6241965
Filing Date: 2001-06-05
Classification: A61K,C07K

Abstract:
A radiotherapeutic agent comprising:a) a linear peptide having a formula:X.sup.1 -A.sup.1 A.sup.2 -B.sup.1 B.sup.2 B.sup.3 B.sup.4 -C.sup.1 C.sup.2 -X.sup.2whereinX.sup.1 and X.sup.2 are each independently hydrophilic moieties;A.sup.1, A.sup.2 and C.sup.1 are each independently a lipophilic D-amino acid, a lipophilic L-amino acid, S-alkylated cysteine, penicillamine, homocysteine, or homohomocysteine;B.sup.1 is D-Phe, L-Phe, D-Tyr, L-Tyr, D-Nal, L-Nal, or Ain;B.sup.2 is D-Trp or L-Trp;B.sup.3 is D-Lys, L-Lys, Hly, Achxa, Amf, Aec, Apc, Aes, or Aps;B.sup.4 is D-Thr, L-Thr, Ser, Val, Phe, Ile, Abu, Nle, Leu, Nva, or Aib; andC.sup.2 is D-Thr, L-Thr, Ser, Val, Phe, Ile, Abu, Nle, Leu, Nva, Nal, or Aib; andb) a cytotoxic radioisotope.