Patent ID: 6306862
Filing Date: 2001-10-23
Classification: A61P,C07J

Abstract:
A triterpene derivative represented by the formula (II) or a pharmaceutically acceptable salt thereof: ##STR19##whereinR.sup.1 represents a hydroxyl group,C.sub.1-6 alkoxy,C.sub.1-6 alkylcarbonyloxy, oraralkyloxy which may be optionally substituted;R.sup.2 represents C.sub.1-6 alkyl,--CH.sub.2 OR.sup.5 wherein R.sup.5 represents a hydrogen atom, C.sub.1-6 alkyl, aralkyl which may be optionally substituted, or C.sub.1-6 alkylcarbonyl,formyl,--COOR.sup.6 wherein R.sup.6 represents a hydrogen atom or C.sub.1-6 alkyl), or--CH.sub.2 N(R.sup.7)R.sup.8 wherein R.sup.7 and R.sup.8, which may be the same or different, represent a hydrogen atom or C.sub.1-6 alkyl; orR.sup.1 and R.sup.2 may combine with each other to form --O--CR.sup.9 (R.sup.10)--OCH.sub.2 -- wherein R.sup.9 and R.sup.10, which may be the same or different, represent a hydrogen atom, a C.sub.1-6 alkyl group, or an aryl group;R.sup.3 and R.sup.4, which may be the same or different, representC.sub.1-6 alkyl,hydroxy C.sub.1-6 alkyl,formyl,--COOR.sup.11 wherein R.sup.11 represents a hydrogen atom or C.sub.1-6 alkyl, or--OR.sup.12 wherein R.sup.12 represents C.sub.1-6 alkyl, aralkyl which may be optionally substituted, arylcarbonyl, C.sub.2-6 alkenyl, C.sub.2-6 alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally substituted; orR.sup.3 and R.sup.4 may combine with each other to form a methylene group;-- -- -- represents a single or double bond, provided that, when -- -- -- represents a double bond, R.sup.4 is absent;when R.sup.1 and R.sup.2 combine with each other to form --O--CR.sup.9 (R.sup.10)--OCH.sub.2 -- wherein any one of R.sup.9 and R.sup.10 represents aryl, R.sup.3 and R.sup.4 may further represent a hydrogen atom or a hydroxyl group;when any one of R.sup.3 and R.sup.4 represents a C.sub.1-6 alkyl group, the other substituent may further represent a hydroxyl group.