Patent ID: 6706740
Filing Date: 2004-03-16
Classification: A01N,A61K,C07D

Abstract:
A compound having the following formula wherein:(a) X1 is N; X2, X3, and X4 are CRâ€³, where Râ€³ is independently H, halogen, cyano, hydroxy, C1-C3 alkyl, C1-C3 haloalkyl, cyclopropyl, C1-C3 alkoxy, C1-C3 haloalkoxy, C1-C3 alkylthio, substituted or unsubstituted aryl, C1-C3 NHC(O)alkyl, NHC(O)H, C1-C3 haloalkylthio, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, CC2-C4 haloalkynyl or nitro; (b) Z is O, S or NORZ in which RZ is H or C1-C3 alkyl; (c) A is where *=point of attachmentâ€ƒin which Q1, Q2 are each O or S, W is O, CH2, CHR6, or a bond, R1 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl, R2 is H, C1-C3 alkyl, C2-C5 alkenyl or C2-C5 alkynyl, R3 is H, R1, OR1, OC(O)OR1 or OC(O)NR1R6, R4 and R5 are independently H, C1-C6 alkyl, or C2-C6 alkenyl, provided that the sum of carbons for R4 plus R5 is six or less, and further provided that R4 and R5 may be joined into a C3-C6 ring, R6 and R7 are independently H, C1-C6 alkyl, C3-C6 cycoalkyl, C2-C5 alkenyl or C2-C5 alkynyl provided that at least one of R6 and R7 is H; with the proviso that the following compounds are excluded wherein R1 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, or C3-C8 cycloalkyl, R3 is H, R1, OR1, OC(O)OR1, or OC(O)NR1R6, R6 is H, C1-C6 alkyl, C1-C6 cycloalkyl, C2-C5 alkenyl, or C2-C5 alkynyl, and M is H, C(O)R8, or SO2R9 where R8 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, alkoxyalkyl, haloalkyl, alkoxyalkenyl, haloalkenyl, alkoxyalkynyl, haloalkynyl, substituted and unsubstituted arylalkyl, substituted and unsubstituted arylalkenyl, substituted and unsubstituted arylalkynyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, C1-C6 alkoxy, C3-C6 cycloalkoxy, C1-C6 haloalkoxy, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C1-C6 thioalkoxy, substituted and unsubstituted arylalkoxy, substituted and unsubstituted arylalkenyloxy, substituted and unsubstituted arylalkyloxy, substituted and unsubstituted boxy, substituted and unsubstituted heteroaryloxy, amino unsubstituted or substituted with one or two C1-C6 alkyl groups, and R9 is C1-C6 alkyl, C2-C6 alkenyl, C3-C6 alkynyl, C3-C6 cycloalkyl, aryl, or heteroaryl; (d) M is Si(t-Bu)Me2, Si(Ph)Me2, SiEt3, SiMe3, C(Z)R8, SO2R9 where R8 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, alkoxyalkyl, haloalkyl, alkoxyalkenyl, haloalkenyl, alkoxyalkynyl, haloalkynyl, substituted and unsubstituted arylalkyl, substituted and unsubstituted arylalkenyl, substituted and unsubstituted arylalkynyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, C1-C6 alkoxy, C3-C6 cycloalkoxy, C1-C6 haloalkoxy, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C2-C6 alkylyloxy, C2-C6 haloalkynyloxy, C1-C6 thioalkoxy, substituted and unsubstituted arylalkoxy, substituted and unsubstituted arylalkenyloxy, substituted and unsubstituted arylalkynyloxy, substituted and unsubstituted aryloxy, substituted and unsubstituted heteroaryloxy, amino unsubstituted or substituted with one or two C1-C6 alkyl groups, and R9 is C1-C6 alkyl, C2-C6 alkelyl, C3-C6 alkynyl, C3-C6 cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.