Patent ID: 9079149
Filing Date: 2015-07-14
Classification: A61K,A61Q,B01J

Abstract:
1. A process for the preparation of a minisuspoemulsion of submicron core/shell particles CS, wherein the starting material is a minisuspoemulsion of a first disperse liquid phase I in a second continuous liquid phase II, said process comprising: adding submicron core-forming particles C to said first disperse liquid phase I, dissolving, in a molecularly disperse manner, a precursor substance PS for the shell S and, optionally, a reactant R, in the first disperse liquid phase I containing the submicron core-forming particles C, and then emulsifying said first disperse liquid I containing the submicron core-forming particles C and the precursor substance PS and, optionally, a reactant R, in said second continuous liquid phase II, thereby forming at least one shell S about the surfaces of the core-forming particles C, wherein said emulsifying occurs by supplying energy in the form of turbulent kinetic energy, in the form of ultrasound waves, by a static mixer, by a micromixer, by impressing laminar drag in the presence of a membrane, by impressing laminar extensional flow in the presence of a membrane, by impressing turbulent drag in the presence of a membrane, or by impressing turbulent extensional flow in the presence of a membrane, wherein the first disperse liquid phase I is in the form of droplets comprising the submicron core-forming particles C for forming the core and the precursor substance PS for forming the shell S dissolved in a molecularly disperse form, wherein the droplets have a mean droplet diameter of ≦5 μm, and wherein two to ten shells S surround the core, each shell S present on top of the previous shell S.