Patent ID: 9011865
Filing Date: 2015-04-21
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an antibody antagonist to c -Met, or a cMet-binding fragment thereof, and an aminoheteroaryl compound, wherein: i) said antibody antagonist to c-Met comprises a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3 comprising, respectively, the amino acid sequences SEQ ID Nos. 47, 48 and 49; and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 comprising, respectively, the amino acid sequences SEQ ID Nos. 50, 51 and 52; and ii) said aminoheteroaryl compound is selected from the group consisting of compounds of formula I: wherein: Y is N or CR R R each R each R each R each R each R R each R each m is independently 0, 1 or 2; each n is independently 0, 1, 2, 3 or 4; each p is independently 1 or 2; and a pharmaceutically acceptable salt, hydrate or solvate thereof.