Patent ID: 6096766
Filing Date: 2000-08-01
Classification: A61P,C07D

Abstract:
A compound of formula (I): ##STR14## wherein R.sup.1 represents a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur, which is optionally substituted by one or two substituents, selected from C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, SR.sup.x, SOR.sup.x, SO.sub.2 R.sup.x, phenyl, NR.sup.a R.sup.b, NR.sup.a COR.sup.x, CH.sub.2 COCF.sub.3 and CF.sub.3, where R.sup.a and R.sup.b are independently hydrogen or C.sub.1-4 alkyl and R.sup.x is C.sub.1-4 alkyl;R.sup.2 represents halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CF.sub.3, OCF.sub.3, NO.sub.2, CN, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or C.sub.1-4 alkyl substituted by C.sub.1-4 alkoxy, where R.sup.a and R.sup.b each independently represent hydrogen or C.sub.1-4 alkyl;R.sup.3 represents hydrogen or C.sub.1-6 alkyl;R.sup.4 represents hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, CF.sub.3, NO.sub.2, CN, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or C.sub.1-4 alkyl substituted by C.sub.1-4 alkoxy, where R.sup.a and R.sup.b each independently represent hydrogen or C.sub.1-4 alkyl;R.sup.5 represents hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy substituted by C.sub.1-4 alkoxy or CF.sub.3 ;R.sup.6a represents hydrogen, methyl or ethyl;R.sup.6b represents C.sub.1-6 alkyl substituted by a hydroxy group;R.sup.9 represents halogen, C.sub.1-6 alkyl, oxo, CO.sub.2 R.sup.a or CONR.sup.a R.sup.b ;m is zero or 1;n is 2;p is zero, 1 or 2; andq is zero, 1 or 2;or a pharmaceutically acceptable salt or prodrug thereof.