Patent ID: 6781000
Filing Date: 2004-08-24
Classification: A61K,A61P,C07K

Abstract:
A compound having the formula: whereinX2 is Arâ€”X3, wherein Ar is indolyl or substituted indolyl; and X3 is â€”CH2C(O)â€”; R1 and R2 are independently alkyl of 1-10 carbon atoms, or alkyl of 1-10 carbon atoms with a substituent chosen from the group consisting of hydroxy, â€”CO2H, â€”CONH2, cyclohexyl, pyridyl, and aryl optionally substituted by hydroxy; X1 is wherein: R3 is hydrogen, alkyl of 1-10 carbon atoms, or alkyl of 1-10 carbon atoms with a substituent chosen from the group consisting of amino, hydroxy, â€”CO2H, â€”CONH2, phenyl, â€”NH(&boxH;NH)NH2, cyclohexyl, imidazolyl, thiazolyl, pyridyl, and aryl optionally substituted by hydroxy; and X4 is hydroxy.