Patent ID: 6835379
Filing Date: 2004-12-28
Classification: C07K

Abstract:
In a method for producing IgG from plasma for medical applications, comprising: (iâ€²) removing any albumin, resulting in an IgG fraction, (iiâ€²) purifying IgG from said IgG fraction, by adsorbing IgG to a cation exchanger and collecting the adsorbed IgG fraction, and (iiiâ€²) inactivating any virus in said purified IgG wherein the improvement comprises(I) concentrating the IgG fraction obtained in step (iâ€²), (II) adjusting pH to 4Â±0.1 in the IgG released from the cation exchanger in step (iiâ€²), and maintaining the pH below 6.0 during the remaining steps of the method; and (III) carrying out the virus inactivation (step iiiâ€²) by using chemicals at a temperature of 30Â° C.Â±2Â° C. for at least 4 hours.