Patent ID: 8748405
Filing Date: 2014-06-10
Classification: A61K,A61P,C07H,C07K,C12N

Abstract:
1. A chimeric molecule comprising a human STAT3 sense strand and a human CpG(D19)-STAT3 antisense strand, wherein the human STAT3 sense strand comprises an oligonucleotide having nucleotides set forth in SEQ ID NO:4, wherein the human CpG(D19)-STAT3 antisense strand comprises (a) a first oligonucleotide having the nucleotides set forth in SEQ ID NO:16, (b) a C3 carbon chain or propanediol linker and (c) a second oligonucleotide having the nucleotides set forth in SEQ ID NO:5 that is the antisense strand, and wherein the sense strand and the antisense strand anneal to form a double stranded siRNA.