Patent ID: 6541474
Filing Date: 2003-04-01
Classification: A61P,C07D

Abstract:
A heterocycle-containing carboxylic acid derivative represented by the following formula (I): whereinA is a group represented by the following formula: R1 and R2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, a lower alkoxy group which may have a substituent, a cycloalkyloxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an aryloxy group which may have a substituent, a heteroaryloxy group which may have a substituent, a cycloalkylalkyl group which may have a substituent, an arylalkyl group which may have a substituent, a heteroarylalkyl group which may have a substituent, a cycloalkylalkyloxy group which may have a substituent, an arylalkyloxy group which may have a substituent, a heteroarylalkyloxy group which may have a substituent, an alkenyl group which may have a substituent or an alkynyl group which may have a substituent, or R1 and R2 are coupled together to form a cycloalkylene group which may have a substituent, a carbon group forming said cycloalkylene group may be substituted by a sulfur atom, an oxygen atom, a sulfinyl group, a sulfonyl group or >NR4, R4 representing a hydrogen atom or a lower alkyl group provided that R1 and R2 are not both hydrogen; B is a heteroarylene group which may have a substituent, an arylene group which may have a substituent, or a group represented by the following formula: wherein R5 represents a hydrogen atom or a lower alkyl group; D is an arylene group which may have a substituent, a heteroarylene group which may have a substituent; n1 is one; M is a hydroxyl group a lower alkoxy group or a group represented by the following formula: â€”NR16R17 in which R16 and R17 are the same or different and each independently represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a hydroxylakyl group, or an aryl group or a heteroaryl group or R16 and R17 are coupled together with the adjacent nitrogen atom to form an oxygen- or sulfur-containing ring.