Patent ID: 8673842
Filing Date: 2014-03-18
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. An SP-C mimic compound comprising an N-terminal component of 2 residues selected from N-substituted glycine residues N oc , N pm and N hd , and Phe and combinations thereof; a sequence selected from peptide sequence ProValHisLeuLysArg (SEQ ID NO: 1) and biomimetic sequences thereof wherein said biomimetic sequences are peptide sequences of SEQ ID NO: 1 wherein at least one peptide sequence residue of SEQ ID NO: 1 is replaced with an N-substituted glycine residue, said N-substituent is the α-carbon sidechain moiety of said replaced peptide sequence residue; and a hydrophobic C-terminal component of said compound of about 12 to about 20 N-substituted glycine residues selected from N pm , N spe and N ssb residues and combinations thereof.