Patent ID: 6713499
Filing Date: 2004-03-30
Classification: A61P,C07D

Abstract:
A compound of the formula I whereinR1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl, C3-6-cycloalkyl, tetrahydropyran-2,3 or 4-yl, piperidin-4-yl, piperidin-4-yl substituted by lower alkyl, â€”(CH2)nâ€”O-lower alkyl, â€”(CH2)nâ€”NRâ€²Râ€³, â€”C(O)-lower alkyl, â€”(CH2)nâ€”C(O)-lower alkyl, â€”(CH2)nâ€”C(O)â€”C3-6-cycloalkyl, â€”(CH2)nâ€”C(O)â€”NRâ€²Râ€³, â€”(CH2)n-phenyl, â€”(CH2)n-phenyl substituted by lower alkyl, lower alkoxy or NRâ€²Râ€³, â€”(CH2)n-pyridinyl, â€”(CH2)n-pyridinyl substituted by lower alkyl, lower alkoxy or NRâ€²Râ€³, â€”(CH2)n-morpholinyl, â€”(CH2)n-tetrahydropyran-2,3 or 4-yl, â€”(CH2)n-piperidin-1 or 4-yl, â€”(CH2)n-piperidin-1 or 4-yl substituted by lower alkyl, â€”C(O)â€”C5,6-cycloalkyl, â€”C(O)-tetrahydropyran-2,3 or 4-yl, â€”C(O)-morpholinyl, â€”C(O)-piperidin-1-yl and â€”C(O)-pyrrolidin-1-yl, or R1 and R2 form together with the N atom to which they are attached the ring 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, an azetidinyl ring, or an azetidinyl ring substituted by lower alkyl or lower alkoxy; R3 is lower alkoxy, phenyl, phenyl substituted by halogen, â€”(CH2)n-halogen, or â€”(CH2)nâ€”N(Râ€²)â€”(CH2)n+1â€”O-lower alkyl, pyridinyl, pyridinyl substituted by lower alkyl, halogen or morpholinyl, morpholinyl, piperidin-1-yl disubstituted in the 4 position by lower alkyl and â€”(CH2)nâ€”OH, or 2-aza-bicyclo[2.2.2] octane; n is 1 or 2; Râ€² and Râ€³ are each independently selected from hydrogen or lower alkyl or together may form with the N atom an azetidinyl-, pyrrolidinyl- or piperidinyl group; and pharmaceutically acceptable acid addition salts thereof.