Patent ID: 6984773
Filing Date: 2006-01-10
Classification: A01K,A61K,C07K,C12N,C12Q,G01N

Abstract:
1. A transgenic mouse whose genome contains a transgene comprising a gene encoding a human steroid and xenobiotic receptor (SXR) polypeptide operably linked to an albumin promoter/enhancer, wherein said SXR polypeptide is a member of the steroid/thyroid hormone superfamily and forms a heterodimer with retinoid X receptor, wherein said heterodimer binds to a direct or inverted repeat response element comprising at least two half sites RGBNNM separated by a spacer of 0 up to 15 nucleotides, wherein: with the proviso that at least 4 nucleotides of said -RGBNNM- sequence are identical with the nucleotides at corresponding positions of the sequence AGTTCA; wherein said transgenic mouse expresses said SXR polypeptide, and wherein said SXR polypeptide inducibly activates transcription in response to a wide variety of natural and synthetic steroid hormones, including at least compounds that induce catabolic enzymes, steroid receptor agonists and antagonists, and bioactive dietary compounds.