Patent ID: 6787546
Filing Date: 2004-09-07
Classification: A61P,C07D

Abstract:
A compound of the formula [I] or a salt thereof:Aâ€”Bâ€”Dâ€”Eâ€”â€ƒâ€ƒ[1]whereinA is a 5- or 6-membered heteroaryl group having one or two nitrogen atoms as ring-composing members or its oxide; B is an ethenylene group optionally substituted by cyano, bromo or C1â€”C6 alkyl; D is a phenylene group optionally substituted by hydroxyl, halogen, amino, C1â€”C6 alkyl or C1â€”C6 alkoxy; and E is a group of the formula: wherein G is a phenyl group optionally substituted by hydroxyl of C1â€”C6 alkoxy; and R is a 5- or 6-membered heteroaryl group having one or two nitrogen atoms as ring-composing members or a 5- or 6-membered heteroarylmethyl group having one or two nitrogen atoms as ring-composing members, or a group of the formula: wherein n is an integer of 1 to 5; R5 and R6 are the same or different and independently selected from the group consisting of hydrogen, C1â€”C6 alkyl, or R5 and R6 taken together with the adjacent nitrogen atom may form a 5- to 7-membered cyclic amino group for â€”NR5(R6) which may optionally be substituted by one or two substituents selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, a 5- to 6-membered heteroaryl group having one to two nitrogen atoms and a 5- to 7-membered cyclic amino group.