Patent ID: 6458951
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound of formula (VA) or (VB): whereinR1 is C1 to C3 alkyl, optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group is optionally substituted by one or more substituents selected from C1 to C4 alkoxy; halo; CN; CF3; OCF3 or C1 to C4 alkyl wherein said C1 to C4 alkyl group is optionally substituted by C1 to C4 haloalkyl or haloalkoxy either of which is substituted by one or more halo atoms; R2 is C1 to C6 alkyl; R13 is OR3or NR5R6; R3 is C1 to C6 alkyl optionally substituted with one or two substituents selected from C3 to C5 cycloalkyl, OH, C1 to C4 alkoxy, benzyloxy, NR5R6, phenyl, furanyl and pyridinyl; C3 to C6 cycloalkyl; 1-(C1 to C4 alkyl)piperidinyl; tetrahydrofuranyl or tetrahydropyranyl and wherein said C1 to C6 alkyl or said C1 to C4 alkoxy groups are optionally substituted by haloalkyl; R5 and R6 are each independently selected from H and C1 to C4 alkyl, optionally substituted with C3 to C5 cycloalkyl or C1 to C4 alkoxy, or, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholinyl group; Het is a C-linked 6-membered heterocyclic group containing one or two nitrogen atoms, optionally in the form of its mono-N-oxide, or a C-linked 5-membered heterocyclic group containing two or three nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1 to C4 alkyl, C1 to C4 alkoxy or NHR15 wherein R15 is H, C1 to C4 alkyl or C1 to C4 alkanoyl; and halo is Br, Cl, F or I.