Patent ID: 6146633
Filing Date: 2000-11-14
Classification: A61P,C07K

Abstract:
Polyclonal antibodies reactive with a reproductive protein hormone endogenous and non-immunogenic to a selected mammalian species, said antibodies being non-immunogenic to and produced in a mammal of said selected species by administering to said mammal, an effective amount of a polypeptide determinant of said reproductive hormone conjugated to a carrier biologically foreign to said selected mammalian species, said polypeptide determinant selected from a group consisting of said reproductive protein hormone endogenous to said selected mammalian species, a fragment of said protein hormone, and a synthetic polypeptide including at least one epitope of said endogenous protein hormone; said polypeptide determinant selected from said group having the properties of:a) prior to conjugation to said carrier, being essentially non-immunogenic to said mammal; andb) after conjugation to said carrier and said administration, causing said antibodies to be formed in said mammal of said selected species which are reactive against said endogenous reproductive protein hormone.