Patent ID: 9084792
Filing Date: 2015-07-21
Classification: A61K,A61P,C07D

Abstract:
1. A method for preparing an acyclovir 2/3 hydrate, the method comprising: mixing acyclovir with water at a weight ratio of from 1:5 to 1:50; dissolving the acyclovir in water at 50-100° C. thereby obtaining an acyclovir water solution; subjecting the acyclovir water solution to filtration; cooling the filtrate to 0-30° C. to precipitate crystals; collecting the crystals by filtration; and drying the crystals at 50-150° C. for 0.5-24 hours, thereby obtaining the acyclovir 2/3 hydrate, wherein the acyclovir 2/3 hydrate has the following characteristic peaks expressed in terms of 2θ and interplanar spacings d value in the X-ray powder diffraction pattern obtained with Cu-Kα radiation: and wherein the acyclovir 2/3 hydrate has a weight-loss as measured by Thermogravimetric Analysis of 5.1% by weight.