Patent ID: 6077690
Filing Date: 2000-06-20
Classification: A61K,A61P,C07K

Abstract:
A isolated DNA fragment which is selected from the group consisting of:(a) a DNA sequence encoding the amino acid sequence represented by the sequence shown in SEQ ID No:1;(b) a DNA sequence which is degenerate as a result of the genetic code to the DNA sequence (a) above; and(c) a DNA sequence which hybridizes under stringent conditions to the complementary sequence of the DNA sequences (a) or (b) above; said isolated DNA fragment encoding a protein of about 54 kDa in molecular weight (determined by Western blotting) which induces proliferation of a Toxoplasma gondii specific human T-cell clone, and is(i) capable of being recognized by and binds to antibodies in sera or other biological samples of T. gondii chronically infected humans or animals; or(ii) capable of raising and raises antibodies following internal administration to a human or an animal.