Patent ID: 6294539
Filing Date: 2001-09-25
Classification: C07D

Abstract:
A compound having the structure and pharmaceutical acceptable salts thereof; ##STR22##wherein:the broken line represents an optional double bond;X is H or O;n is 0 or 1;R.sub.1 is hydrogen, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, said alkyl and alkenyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.2 is hydrogen, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, said alkyl, alkenyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.3 and R.sub.4 independently are hydrogen, trifluoromethyl, C.sub.5 -C.sub.10 aryl, C.sub.5 -C.sub.10 heteroaryl, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.4 -C.sub.10 heterocyclyl, C.sub.5 -C.sub.10 aryl-C.sub.1 -C.sub.10 alkyl, C.sub.5 -C.sub.10 heteroaryl-C.sub.1 -C.sub.10 alkyl, --COR.sub.8, --CO.sub.2 R.sub.8, --CONR.sub.8 R.sub.9, --SO.sub.2 NR.sub.8 R.sub.9, said aryl, heteroaryl, alkyl, alkenyl, cycloalkyl, and heterocyclyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.5 is hydrogen, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, said alkyl and alkenyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.6 is hydrogen, trifluoromethyl, C.sub.5 -C.sub.10 aryl, C.sub.5 -C.sub.10 heteroaryl, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.4 -C.sub.10 heterocyclyl, C.sub.5 -C.sub.10 aryl-C.sub.1 -C.sub.10 alkyl, C.sub.5 -C.sub.10 heteroaryl-C.sub.1 -C.sub.10 alkyl, said aryl, heteroaryl, alkyl, alkenyl, cycloalkyl, and heterocyclyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.7 is C.sub.5 -C.sub.10 aryl, C.sub.5 -C.sub.10 heteroaryl, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.10 heterocyclyl, said aryl, heteroaryl, alkyl, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of R.sub.s ;R.sub.8 and R.sub.9 independently are hydrogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.4 -C.sub.10 heterocyclyl, C.sub.5 -C.sub.10 aryl, C.sub.5 -C.sub.10 heteroaryl;R.sub.s represents a member selected from the group consisting of halo, cyano, nitro, trihalomethyl, carbamoyl, hydroxy, trifluoromethoxy acyl, aryl, heteroaryl, --S(O)R.sub.8, .dbd.N(OR.sub.8), --SO.sub.2 R.sub.8, --COOR.sub.8, --CONR.sub.8 R.sub.9, --C.sub.1 -C.sub.6 alkylCONR.sub.8 R.sub.9, C.sub.1 -C.sub.6 alkyloxy, aryloxy, arylC.sub.1 -C.sub.6 alkyloxy, thio, C.sub.1 -C.sub.6 alkylthio, arylthio, arylC.sub.1 -C.sub.6 alkylthio, NR.sub.7 R.sub.8, C.sub.1 -C.sub.6 alkylamino, arylamino, arylC.sub.1 -C.sub.6 alkylamino, di(arylC.sub.1 -C.sub.6 alkyl)amino, C.sub.1 -C.sub.6 alkylcarbonyl, arylC.sub.1 -C.sub.6 alkylcarbonyl, C.sub.1 -C.sub.6 alkylcarboxy, arylC.sub.1 -C.sub.6 alkylcarboxy, --NR.sub.9 CO.sub.2 R.sub.8, --NR.sub.9 COR.sub.8, --NR.sub.9 O.sub.2 R.sub.8, --NR.sub.9 O.sub.2 R.sub.8, --CONR.sub.8 R.sub.9, --SO.sub.2 NR.sub.8 R.sub.9, --OCONR.sub.8 R.sub.9, --C.sub.1 -C.sub.6 alkylaminoCONR.sub.8 R.sub.9, arylC.sub.1 -C.sub.6 alkylcarbonylamino, tetrahydrofuryl, morpholinyl, piperazinyl, or a saturated or partial saturated cyclic 5,6 or 7 membered amine or lactam.