Patent ID: 6787153
Filing Date: 2004-09-07
Classification: A61K,C07K,Y10S

Abstract:
A pharmaceutical composition comprising a therapeutically effective amount of a monoclonal antibody fragment bound to the surface of a liposome enclosing an anti-cancer agent or toxin to cancer cells and a pharmaceutically acceptable carrier therefor,said liposome comprising phosphatidylcholine, cholesterol and phosphatidylethanolamine, said liposome being modified with poly(ethylene glycol), wherein the poly(ethylene glycol) is bound to the surface of the liposome through a maleimide group, said antibody fragment belonging to IgG class or IgM class and specifically binding to a surface antigen of a stomach and colon cancer cell membrane, and said antibody fragment having a variable region of the heavy chain which comprises the amino acid sequence shown in SEQ ID No:5 and having a variable region of the light chain which comprises the amino acid sequence shown in SEQ ID No:6.