Patent ID: 6762329
Filing Date: 2004-07-13
Classification: C07B,C07C

Abstract:
The method depicted in scheme 1: whereinAr and Arâ€² independently represent optionally substituted monocyclic or polycyclic aromatic or heteroaromatic moieties; X represents Cl, Br, I, â€”O3S(alkyl), or â€”O3S(aryl); Y represents O, S, Se, NR, PR, or AsR; Z represents H, a group that is lost under the reaction conditions to generate a negative charge on Y, or a group that is replaced by H under the reaction conditions; R represents H, alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, trialkylsilyl, acyl, or sulfonyl; catalyst is selected from the group consisting of copper carboxylates, copper carbonates, copper sulfates, copper sulfonates, and copper halides; co-catalyst represents a uncharged molecule comprising a Lewis basic pair of electrons; alkali salt represents a salt selected from the group consisting of cesium bicarbonate, cesium carbonate, cesium, carboxylates, and cesium phosphates; the reaction takes place at a temperature in the range of about 25-150Â° C.; and the method is not conducted in an amine solvent or an aqueous solvent.