Patent ID: 6420523
Filing Date: 2002-07-16
Classification: A61K,C07K,C12N,Y02A

Abstract:
A composition comprising a polypeptide expressed by an insect cell which contains a baculovirus vector that encodes said polypeptide, wherein said polypeptide consists of a fragment of surface protein gp195 from Plasmiodium falciparum, said fragment consisting of an amino acid sequence selected from the group consisting of:(a) amino acids 1 to 373 of the amino acid sequence of SEQ ID NO:2; (b) amino acids 1 to 354 of the amino acid sequence of SEQ ID NO:3; (c) amino acids 1 to 373 of the amino acid sequence of SEQ ID NO:4; and (d) amino acids 1 to 356 of the amino acid sequence of SEQ ID NO:5, wherein the amino acid sequence of (a), (b), (c) or (d) of said polypeptide is more immunogenic in a mammalian host than is a polypeptide having the same amino acid sequence expressed in yeast.