Patent ID: 6372495
Filing Date: 2002-04-16
Classification: A61M,C12M,C12N

Abstract:
A bio-artificial organ system comprising a wall surrounding a space, said space comprising:(a) a solid support for cell cultivation consisting of a three dimensional matrix in the form of a highly porous sheet or mat, wherein the three dimensional matrix comprises a physiologically acceptable network or fibers or a physiologically acceptable open pore foam structure, wherein the matrix has a porosity of from 40 to about 95% and a pore size of from 10 &mgr;m to 100 &mgr;m, and an overall height of from 50 &mgr;m to about 200 &mgr;m; and (b) conduits for supplying gaseous oxygen; wherein said conduits are hollow fibers made of a hydrophobic material and having an outer diameter of 0.1 mm to 1.0 mm, wherein said hollow fibers are evenly distributed through the three dimensional matrix and are arranged in parallel running from one end of the matrix to the other end of the matrix, wherein the distance between individual hollow fibers is between 0.1 mm and 5 mm.