Patent ID: 8323615
Filing Date: 2012-12-04
Classification: A61K,B01D

Abstract:
1. A method of processing multi-phasic dispersions comprising: providing a multi-phasic dispersion including dispersed and continuous phases, the dispersion comprising solid microparticles and at least a first non-volatile material; providing a non-solvent, combining the multi-phasic dispersion and the non-solvent; and selectively effecting migration of the microparticles into or through the non-solvent such that a majority of the microparticles is separated from the dispersion, wherein the continuous phase is either aqueous or aqueous-miscible, the first non-volatile material comprises a non-ionic aqueous-soluble polymer or a non-ionic aqueous-miscible polymer, the microparticles arc substantially insoluble in the non-solvent and the non-solvent has either a density which is greater than that of the continuous phase or a viscosity which is greater than that of the continuous phase, wherein providing the non-solvent comprises introducing the non-solvent into a centrifugation apparatus, thereby forming a non-solvent layer therein, combining the multi-phasic dispersion and the non-solvent comprises layering the multi-phasic dispersion on a top surface of the non-solvent layer, thereby forming a layered composition; and selectively effecting migration of the microparticles into or through the non-solvent comprises centrifuging the layered composition.