Patent ID: 6702995
Filing Date: 2004-03-09
Classification: A61K

Abstract:
A composition of matter comprising a water-insoluble drug or other therapeutic or diagnostic agent that is carried internally within a hydraphobic or lipophilic pocket or pockets in a water-miscible amphiphilic polymer which comprises q monomer units of the formula[((CHR)nâ€”(CRR1)m(CHR)p)vâ€”A]and u monomer units of the formula[((CHR)râ€”(CRR2)sâ€”(CHR)t)wâ€”B], wherein A and B are independently CH2, or NH;wherein n, m, p, r, s, t independently are any whole number as long as (n+m+p)v+(r+s+t)w ranges from 1-1000, and the ratio v/w varies between 0.1 and 10.0; wherein the values of q and u independently are from 1-10; wherein each R, independently, is selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, alkenyl and alkynyl; wherein R1 is a hydrophobic moiety containing an aromatic hydrocarbon ring; wherein R2 is a hydrophobic moiety that provides water-solubility and is selected from the group consisting of â€”OH, a hydroxyalkyl, a polyoxyethylene moiety, a hydroxyphenyl, a substituted hydroxyphenyl, a pyrrolidine moiety, an N-oxide pyridine moiety, an N-oxide moiety, an N-oxide histidine moiety, a tryptophan moiety, a phenylalanine moiety, a tyrosine moiety, a phenyl sulphonate moiety, a naphthalene sulphonate moiety, an imidazole moiety, a water soluble naphthalene salt, an anthracene moiety, a phenanthrene moiety, a phenyl, a carbazole moiety, a xanthene moiety, an acridine moiety, a purine moiety, a pyridazine moiety, an indole moiety, â€”COOH, â€”COOM, SO3M, â€”NR2 and â€”NR3+Xâˆ’, wherein X is a halide ion and M is an alkali metal ion.