Patent ID: 6326387
Filing Date: 2001-12-04
Classification: A61K,A61P

Abstract:
A pharmaceutically acceptable composition comprising:a) a neurotrophic amount of a compound with affinity for FKBP12 having the formula (I): ##STR11##or pharmaceutically acceptable derivatives thereof, wherein A in O, NH, or N--(C1-C4 alkyl);B is hydrogen, CHL--Ar, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, (C5-C7)-cycloalkyl, (C5-C7)-cycloalkenyl or Ar substituted (C1-C6)-alkyl or (C2-C6)-alkenyl, or ##STR12##wherein L and Q are independently hydrogen, (C1-C6)-straight or branched alkyl or (C2-C6)-straight or branched alkenyl; andT is Ar or substituted cyclohexyl with substituents at positions 3 and 4 which are independently selected from the group consisting of hydrogen, hydroxyl, O--(C1-C4)-alkyl or O--(C2-C4)-alkenyl;wherein Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2-furyl, 3-furyl, 2-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl and phenyl having one to three substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, CF.sub.3, (C1-C6)-straight or branched alkyl or (C2-C6)-straight or branched alkenyl, O--(C1-C4)-straight or branched alkyl or O--((C2-C4)-straight or branched alkenyl), O-benzyl, O-phenyl, amino and phenyl;D is U;E is either oxygen or CH--U, provided that if D is hydrogen, then E is CH--U or if E is oxygen then D is not hydrogen;wherein each U is independently selected from hydrogen, O--(C1-C4)-straight or branched alkyl or O--((C2-C4)-straight or branched alkenyl), (C1-C6)-straight or branched alkyl or (C2-C6)-straight or branched alkenyl, (C5-C7)-cycloalkyl or (C5-C7)-cycloalkenyl substituted with (C1-C4)-straight or branched alkyl or (C2-C4)-straight or branched alkenyl, 2-indolyl, 3-indolyl, [(C1-C4)-alkyl or (C2-C4)-alkenyl]-Ar or Ar;J is hydrogen or C1 or C2 alkyl;K is (C1-C4)-straight or branched alkyl, benzyl or cyclohexylmethyl; or J and K are taken together to form a 5-6 membered heterocyclic ring which contains a second heteroatom or heterogroup selected from O, S, SO or SO.sub.2 ; or J and K are taken together to form a 7-membered heterocyclic ring optionally containing a second heteroatom or heterogroup selected from O, S, SO or SO.sub.2 ; andthe stereochemistry at carbon position 1 is R or S;b) a neurotrophic factor; andc) a pharmaceutically acceptable carrier.