Patent ID: 6297242
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A compound of Formula I: ##STR15##whereinR is H, alkyl, cycloalkyl, OR.sub.1, SR.sub.1, amino, NHR.sub.1, NR.sub.1 R.sub.2, C.sub.1 -C.sub.8 alkylaryl, or mono-, di-, tri- or per-halo-C.sub.1 -C.sub.8 alkyl;W is H, CN, COR.sub.1, COOR.sub.1, CONHR.sub.1, CO--NR.sub.1 R.sub.2, SO.sub.2 R.sub.2, SO.sub.2 NHR.sub.1, SO.sub.2 --NR.sub.1 R.sub.2, or NO.sub.2 ;R.sub.1 and R.sub.2 are independently H, alkyl, or mono-, di-, tri- or per-halo-C.sub.1 -C.sub.8 alkyl, or, in the case of --NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 taken together with the nitrogen may be a cyclic amino derivative;X is H, CN, COR.sub.1, COOR.sub.1, CONHR.sub.1, CO--NR.sub.1 R.sub.2, SOR.sub.1, SO.sub.2 R.sub.1, SO.sub.2 NHR.sub.1, SO.sub.2 --NR.sub.1 R.sub.2, NO.sub.2, C.sub.1 -C.sub.8 alkyl, OR.sub.1, SR.sub.1, amino, NHR.sub.1, NR.sub.1 R.sub.2, C.sub.1 -C.sub.8 alkylaryl, halogen, halo-alkyl, alkoxy, heteroaryl, or aryl; andY is 0 to 4 members independently selected from the group consisting of H, halogen, OH, mercapto, nitro, halo-C.sub.1-8 -alkyl, C.sub.1-8 alkoxyl, thio-C.sub.1-8 -alkyl, C.sub.1-8 alkyl-amino, di(C.sub.1-8 -alkyl-)amino, formyl, carboxy, alkoxycarbonyl, C.sub.1-8 alkyl-CO--O--, C.sub.1-8 alkyl-CO--NH--, carboxamide, aryl, substituted-aryl, heteroaryl, substituted-heteroaryl, CN, amine, alkoxy, NHCO--(C.sub.1-8 alkyl), C.sub.3-6 cycloalkyl, C.sub.1-8 alkyl optionally substituted with one or more members selected from the group consisting of F, Cl, OH, C.sub.1-8 alkoxyl and C.sub.1-8 acyloxy;and optical isomers, enantiomers, diastereomers, racemates and racemic mixtures thereof, or pharmaceutically acceptable salts thereof.