Patent ID: 7311916
Filing Date: 2007-12-25
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A conjugate polypeptide formed from two or more amino acid sequences that comprise: (a) a first gp41 polypeptide having an amino acid sequence corresponding to a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:3 and is capable of forming a stable coiled-coil structure; and (b) a second gp41 polypeptide having an amino acid sequence corresponding to a polypeptide comprising the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6 and is capable of forming an amphipathic α helical segment; wherein at least three polypeptides of (a) and (b) are alternately linked to one another via a peptide bond to form the conjugate polypeptide or at least two polypeptides of (a) and (b) are linked by an amino acid linking sequence consisting of about 2 to about 25 amino acids to form the conjugate polypeptides.