Patent ID: 8026358
Filing Date: 2011-09-27
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (I), optionally in the form of a salt: in which: R is a hydrogen, —CH═CH wherein R′a is hydrogen, methyl, ethyl, n-propyl, or i-propyl, R′ is hydrogen or R′b wherein R′b is methyl, ethyl, n-propyl or i-propyl, the method comprising: condensing, in an acidic medium, a compound of formula (II) in which R′b is as defined above for (I), with a compound of formula (III): in which R″ is selected from hydrogen, —CH═CH 2 , —CH 2 —CH 3 , —CH(OH)CH 3 , —C(O)CH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 OC(O)CH 3 and —CH 2 CH 2 Cl or —CH 2 CH 2 COOR′a, wherein R′a is hydrogen, methyl, ethyl, n-propyl, or i-propyl, so as to form the compound of formula (I′): in which R″ and R′b are as defined above for (II) and (III), and, when R″ and R are not the same moiety, further comprising converting R″ to R, and when R′═H, further comprising eliminating R′b so as to form —COOH moieties, optionally in the form of a salt.