Patent ID: 8410263
Filing Date: 2013-04-02
Classification: A61K,A61P,C07C,C07D,C07F

Abstract:
1. In a process for synthesizing a purified sample of a compound of Formula 1: wherein: M is Gd each X is independently selected from the group consisting of OH R R R R each x is independently selected from the group consisting of 1, 2, 3, 4, 5, and 6; the improvement comprises synthesizing a purified sample of a compound of Formula 1 wherein each x is 3 in at least about 98.4% of compounds of Formula 1 in the purified sample; the process comprising the steps of: i. pegylating a compound of Formula 6 comprising reacting a compound of Formula 7 in tetrahydrofuran to provide a compound of Formula 5 having the structure: