Patent ID: 6103715
Filing Date: 2000-08-15
Classification: A61P,C07D

Abstract:
A compound of Formula I: ##STR30## wherein: A and B independently are both benzene optionally substituted with 1 or 2 substituents selected independently from hydroxyl, halo, selected independently from hydroxyl, halo, C.sub.1-4 alkyl, amino, nitro, cyano, halo-substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halo-substituted C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 acyl, halo-substituted C.sub.1-4 acyl cyclo-C.sub.1-7 alkyl, thio-C.sub.1-4 alkylene, C.sub.1-4 alkylthio, halo-substituted C.sub.1-4 alkylthio, cyanothio, tetrazolyl, N-piperidinyl, N-piperazinyl, N-morpholinyl, acetamido, C.sub.1-4 alkylsulfonyl, halosulfonyl, halo-substituted C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfoxyl, sulfonamido C.sub.1-4 alkylseleno, and OSO.sub.3 H;X.sub.1 is selected from NH, N--C.sub.1-4 alkyl and N-acetyl,X.sub.2 is N=Y is selected from CH and N;R.sub.1 represents C.sub.1-4 alkyl;n is 0, 1 or 2;q is 1 or 2;R.sub.2 is C.sub.1-6 alkylene optionally incorporating an intervening or terminating heteroatom selected from N, O and S;D is cyclohexane or benzene; andE is a saturated or unsaturated 5- or 6-membered heterocycle incorporating 1, 2 or 3 heteroatoms selected from O, N, and S, wherein E is optionally substituted with 1 or 2 substituents selected from halogen, C.sub.1-4 alkyl and halogen-substituted C.sub.1-4 alkyl;and acid addition salts, solvates or hydrates thereof.