Patent ID: 7776826
Filing Date: 2010-08-17
Classification: A61F,A61K,A61P,Y10S

Abstract:
1. A method of inducing bone formation in a subject suffering from diminished bone mass or bone trauma, said method comprising a medical treatment including the steps of: (a) targeting for treatment at least one bone of said subject, each said targeted bone defining a bone marrow cavity therein, said bone marrow cavity containing a quantity of bone marrow and a plurality of osteoblasts; (b) mechanically altering the contents of said cavity by a surgical treatment thereof to thus induce an increase in osteoblast activity therein; and (c) administering to said subject at least one bone anabolic agent for a duration and at a concentration sufficient to raise blood levels of said anabolic agent within said subject above natural levels thereof to thereby prolong said increased osteoblast activity, such that the mechanical alteration of the bone marrow cavity permits specific bones of said subject to be targeted by said method to permit enhanced bone formation therein, wherein step (b) is performed no later than step (c) and in sufficient time proximity that the elevated concentration of said bone anabolic agent and said increased osteoblast activity at least partially overlaps.