Patent ID: 7622100
Filing Date: 2009-11-24
Classification: G01N

Abstract:
1. A method for aiding in the diagnosis that a human is having transient ischemic attacks (TIA), pre-stroke, acute stroke, or traumatic brain injury (TBI) comprising: a) obtaining a test sample of human blood, serum, or plasma from a human subject at the time the human subject is suspected of having transient ischemic attacks (TIA), pre-stroke, acute stroke, or traumatic brain injury (TBI); b) analyzing the obtained test sample for the amount of NR2A N-terminal domain fragment peptide having SEQ ID NO:3 and NR2B N-terminal domain fragment peptide having SEQ ID NO:12 (NR2A-B receptor peptides); c) comparing the result of step (b) with a corresponding reference amount of said NR2A-B receptor peptides, wherein the corresponding reference amount is derived from a population of apparently healthy human subjects; and d) if the amount determined in step (b) exceeds the corresponding reference amount, diagnosing said human as having an increased probability of having transient ischemic attacks (TIA), pre-stroke, acute stroke, or traumatic brain injury (TBI).