Patent ID: 8293722
Filing Date: 2012-10-23
Classification: A61K,A61P

Abstract:
1. A method for treating or ameliorating a bone defect, wherein the bone defect is the result of a post-traumatic injury or a delayed healing or non-union of bone fractures in a mammal in need of such treatment, comprising the step of administering an amount of an oversulfated polysaccharide effective to inhibit cathepsin K, and thereby treat or ameliorate the bone defect, wherein the bone defect is the result of a post-traumatic injury or a delayed healing or non-union of bone fractures, wherein the effective amount an oversulfated polysaccharide is 0.1-30 mg/kg of body weight, wherein the oversulfated polysaccharide is selected from the group consisting of calcium xylopyranose polysulfate and calcium pentosan polysulfate.