Patent ID: 6071936
Filing Date: 2000-06-06
Classification: C07D

Abstract:
A compound of Formula I ##STR58## or a pharmaceutically acceptable salt thereof wherein: R.sup.1 is selected from the group consisting of:(a) CH.sub.3,(b) NH.sub.2,(c) NHC(O)CF.sub.3 and(d) NHCH.sub.3 ;Ar is a mono-, di-, or tri-substituted pyridinyl or pyridinyl-N-oxide, wherein the substituents are selected from the group consisting of:(a) hydrogen,(b) halo,(c) C.sub.1-6 alkoxy,(d) C.sub.1-6 alkylthio,(e) CN,(f) C.sub.1-6 alkyl,(g) C.sub.1-6 fluoroalkyl,(h) N.sub.3,(i) --CO.sub.2 R.sup.3,(j) hydroxy,(k) --C(R.sup.4)(R.sup.5)--OH,(l) --C.sub.1-6 alkyl-CO.sub.2 --R.sup.6 and(m) C.sub.1-6 fluoroalkoxy;R.sup.2 is selected from the group consisting of:(a) CN,(b) C.sub.1-6 fluoroalkyl,(c) --CO.sub.2 C.sub.1-6 alkyl,(d) --C(R.sup.8)(R.sup.9)--OH and(e) --C.sub.1-6 alkyl-CO.sub.2 --R.sup.10 ; andR.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.8, R.sup.9 and R.sup.10 are each independently selected from the group consisting of:(a) hydrogen and(b) C.sub.1-6 alkyl,or R.sup.4 and R.sup.5 or R.sup.8 and R.sup.9 together with the atom to which they are attached form a saturated monocyclic ring of 3, 4, 5, 6 or 7 atoms.