Patent ID: 7824695
Filing Date: 2010-11-02
Classification: A61K,A61P

Abstract:
1. A method of systemically delivering an effective dose of a bioactive moiety to produce a systemic effect in a mammal in need thereof, said method comprising contacting a mucosal membrane of the mammal with a recombinant protein drug that comprises: (1) a cell recognition moiety that binds to an α2 macroglobulin receptor, and (2) the bioactive moiety, which: wherein, the bioactive moiety is translocated across the mucosal membrane of a mammal from the apical surface of the membrane through the basal surface of the membrane to enter a sub-membrane space below the mucosal membrane in an amount which delivers an effective dose of the protein drug to the mammal to produce the systemic effect; and further, wherein, when the protein drug comprises a