Patent ID: 6498147
Filing Date: 2002-12-24
Classification: A01K,A61K,A61P,C12N

Abstract:
An antisense oligonucleotide of complementary to translation initiation region of a nuclear factor-&kgr;B (NF-&kgr;B) subunit mRNA and that hybridizes to a target nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4, wherein the antisense oligonucleotide has a sequence comprising at least an eight nucleotide portion of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8, wherein the antisense oligonucleotide contains not more than 40 nucleotides, and wherein the antisense oligonucleotide hybridizes to the NF-&kgr;B subunit amd inhibits translation of the mRNA.