Patent ID: 6251893
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A compound according to Formula I and a salt, solvate or hydrate thereof: ##STR84##wherein:R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from the group consisting of H, halo, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, C.sub.4-7 cycloalkenyl, C.sub.3-7 cycloalkoxy, C.sub.3-7 cycloalkylthio, halo-substituted-C.sub.1-6 alkyl, C.sub.1-6 alkylthio, C.sub.2-7 alkanoyl, C.sub.2-7 alkanoyloxy, nitro, cyano, optionally substituted phenyl, optionally substituted furanyl, optionally substituted thienyl, optionally substituted phenyloxy, NR.sup.8 R.sup.9, C(O)NR.sup.8 R.sup.9, SO.sub.2 NR.sup.8 R.sup.9, CH.sub.2 SO.sub.2 NR.sup.8 R.sup.9, CO.sub.2 R.sup.10, NHC(O)R.sup.11, NHC(NR.sup.12)R.sup.11, C(NR.sup.13)NR.sup.14 R.sup.15, C(O)R.sup.16, OC(O)R.sup.16, SCF.sub.3, SO.sub.2 CF.sub.3, formyl, CF.sub.3 and CF.sub.3 O;R.sup.5 is selected from the group consisting of SO.sub.2 Ar, C(O)Ar, CH.sub.2 Ar and Ar;R.sup.6 is independently selected from the group consisting of H, C.sub.1-6 alkyl, optionally substituted phenyl and optionally substituted benzyl R.sup.7 is independently selected from the group consisting of H, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, optionally substituted phenyl, optionally substituted benzyl, optionally substituted phenoxy and optionally substituted benzyloxy;-- -- -- -- -- represents a single or double bond;n is selected from an integer of from 1-3;X is selected from the group consisting of CR.sup.17 and N;Z is selected from the group consisting of C, CH and N, provided that when -- -- -- -- -- is a double bond, Z is C and when -- -- -- -- -- is a single bond, Z is selected from CH and N;Ar is an optionally substituted aromatic group selected from the group consisting of phenyl, pyridyl, thienyl, furanyl, naphthyl, quinolyl and isoquinolyl wherein the optional substituents are independently selected from 1-4 members of the group consisting of halo, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, CF.sub.3 and CF.sub.3 O;R.sup.8, R.sup.9 and R.sup.10 are independently selected from the group consisting of H, C.sub.1-6 alkyl and phenyl or R.sup.8 and R.sup.9 may form an alkylene chain, --(CH.sub.2).sub.m --, where m=3-6, to form, together with the nitrogen to which they are attached a 4- to 7-membered ring;R.sup.11 is selected from the group consisting of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, phenyl, phenoxy, NH.sub.2, alkylamino, dialkylamino, benzyl and benzyloxy;R.sup.12 is selected from the group consisting of H and C.sub.1-6 alkyl;R.sup.13 is selected from the group consisting of H and C.sub.1-6 alkyl;R.sup.14 and R.sup.15 are independently selected from the group consisting of H and C.sub.1-6 alkyl or one of R.sup.14 and R.sup.15, together with R.sup.13, forms an alkylene chain, --(CH.sub.2).sub.p --, where p=2 or 3, bridging the nitrogen atoms to which they are attached;R.sup.16 is selected from the group consisting of optionally substituted phenyl, optionally substituted pyridyl, optionally substituted thienyl, optionally substituted furanyl and optionally substituted naphthyl; andR.sup.17 is selected from the group consisting of H, C.sub.1-6 alkyl and benzyl.