Patent ID: 6492356
Filing Date: 2002-12-10
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I in which:R1 and R2 together are a saturated or unsaturated bivalent (C2-C9)-alkylene radical and thereby form a ring, which is unsubstituted or is substituted by one or more groups selected from the group consisting of halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C6)-alkyl-, (C5-C14)-heteroaryl, (C5-C14)-heteroaryl-(C1-C6)-alkyl-, (C3-C12)-cycloalkyl, (C3-C12)-cycloalkyl-(C1-C6)-alkyl- and oxo, where a 5-membered to 7-membered saturated or unsaturated ring may be fused to adjacent carbon atoms of the (C2-C9) alkylene radical, thereby forming a bicyclic structure and is unsubstituted or is substituted by R3, wherein said 5-membered to 7-membered saturated or unsaturated ring is a carbocyclic ring or a heterocyclic ring containing one or two nitrogen atoms; R3 is (C1-C8)-alkyl, (C1-C8)-alkoxy, (C5-C14)-aryl, (C5-C14)-aryl(C1-C4)-alkyl-, halogen, trifluoromethyl, hydroxyl, nitro, or amino; R4 is hydrogen, (C1-C6)-alkyl-COâ€”Oâ€”(C1-C4)-alkyl- or (C1-C6)-alkyl, which is unsubstituted or substituted by a radical selected from the group consisting of hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl-S(O)2â€”, NR7R7â€² and N+R7, R7â€²R7â€³Q31 , wherein R7, R7â€²and R7â€³independently of one another are hydrogen, (C1-C6)-alkyl, (C5-C14)-aryl or (C5-C14)-aryl-(C1-C6)-alkyl- and Qâˆ’ is a physiologically tolerable anion, â€ƒor in which R4 is one of the radicals in which the bonds, via which the radicals are bonded, are indicated by dashed lines;R5 is (C1-C6)-alkyl, (C6-C14)-aryl-(C1-C6)-alkyl- or (C5-C14)-heteroaryl-(C1-C6)-alkyl-, where the aryl radical or the heteroaryl radical is unsubstituted or is substituted by one, two or three radicals R3; R6 is hydrogen, (C1-C6)-alkyl-Oâ€”COâ€”, hydroxyl, (C1-C6)-alkyl-Oâ€”COâ€”Oâ€” or nitro; A is CH2, O, S or NH; m is 1, 2or 3; n is 0 or 1; in all its stereoisomeric forms and mixtures thereof in all ratios, or its physiologically tolerable salt.