Patent ID: 6720452
Filing Date: 2004-04-13
Classification: A61P,C07C,C07D

Abstract:
A compound of general formula wherein D represents CH2 or CH2CH2;E represents C(O)NH or NHC(O); R1 and R2 each independently represent a hydrogen or halogen atom, or an amino, nitro, C1-C6 alkyl or trifluoromethyl group; R3 represents a group of formula â€ƒX represents an oxygen or sulphur atom or a group NH, SO or SO2; Y represents an oxygen or sulphur atom or a group NR11, SO or SO2; Z represents a group â€”OH, â€”SH, â€”CO2H, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6-alkylsulphinyl, C1-C6-alkylsulphonyl, â€”NR6R7, â€”C(O)NR8R9, imidazolyl, 1-methylimidazolyl, â€”N(R10)C(O)â€”C1-C6 alkyl, C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyloxy, â€”OC(O)NR12 R13, â€”OCH2OC(O)R14, â€”OCH2OC(O)OR15 or â€”OC(O)OCH2OR6; R4 represents a linear or branched C2-C6 alkylene group; R5 represents a linear or branched C1-C6 alkylene group; R6, R7, R8, R9, R10, R12 and R13 each independently represent a hydrogen atom, or a C1-C6 alkyl group optionally substituted by at least one hydroxyl group; R11 represents a hydrogen atom, or a C1-C6 alkyl group optionally substituted by at least one substituent independently selected from hydroxyl and C1-C6 alkoxy; and R14, R15 and R16 each independently represent a C1-C6 alkyl group; with the provisos that (i) when E represents NHC(O), X represents O, S or NH and Y represents O, then Z represents â€”NR6R7 where R6 represents a hydrogen atom and R7 represents either a hydrogen atom or a C1-C6 alkyl group substituted by at least one hydroxyl group, and (ii) when E represents NHC(O), X represents O, S or NH, Y represents NH and R5 represents CH2CH2, then Z is not â€”OH or imidazolyl; or a pharmaceutically acceptable salt or solvate thereof.