Patent ID: 7371562
Filing Date: 2008-05-13
Classification: B01L,G01N,G02B,Y10S

Abstract:
1. A biosensor comprising: (a) a one-dimensional grating surface structure comprised of a material having a low refractive index; (b) a high refractive index material layer that is applied on top of the low refractive index one-dimensional grating layer; and (c) one or more specific binding substances immobilized on a surface of the high refractive index layer opposite of the one-dimensional grating surface structure comprised of a material having a low refractive index; wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free, wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.