Patent ID: 7826975
Filing Date: 2010-11-02
Classification: G01N,G16B

Abstract:
1. A computer-assisted method for identifying functionalities to add to an organism-specific microbial metabolic network to enable a desired biotransformation in a production host, comprising: a computer having an organism-specific microbial metabolic network representation stored in a memory and implementing instructions for; accessing reactions from a universal database to provide stoichiometric balance to metabolic reactions; identifying at least one stoichiometrically balanced pathway at least partially based on the reactions of said universal database and a substrate, wherein said identified at least one stoichiometrically balanced pathway increases the yield of a product and minimizes a number of non-native functionalities in the production host; identifying functionalities of said at least one stoichiometrically balanced pathway, thereby identifying functionalities to add to the organism-specific microbial metabolic network to enable a desired biotransformation in a production host; and producing a visual output to a user of the identified functionalities of said at least one stoichiometrically balanced pathway.