Patent ID: 7807782
Filing Date: 2010-10-05
Classification: A61K,C07K,C12N

Abstract:
1. Method for linking of two or more molecular substances with each other through adapter segments, said method comprising: (a) modifying one of the molecular substances in such a way that it exhibits as an adapter segment, in at least one region, a WW domain, (b) modifying another molecular substance in such a way that it exhibits as an adapter segment, in at least one region, a proline-rich sequence, which binds to the WW domain, and (c) forming a covalent bond between the molecular substances by interaction between said WW domain and said proline-rich sequence, wherein said molecular substances are members selected from the group consisting of antibodies, substances analogous to antibodies, enzymes, structural proteins, peptide antibiotics, isolated structure-forming, catalytic, or regulatory protein domains, fragments or proteins, peptides, peptide analogs, antigen-bearing substances, glucoproteins, lipoproteins, and proteoglycans.