Patent ID: 9120856
Filing Date: 2015-09-01
Classification: C07K

Abstract:
1. An anti-CD19 antibody modified to comprise a variant human IgG Fc region, wherein this variant region comprises an amino acid substitution at each of the amino acid positions 243, 292, 300, 305 and 396 of the human IgG Fc region, with the proviso that position 326 or 333 or both positions 326 and 333 are not substituted, wherein the numbering of the amino acid residues in the Fc region is the one of Kabat, and wherein the antibody has been produced in wild-type rodent cells, wherein the antibody recognizes a non-internalizing epitope on the CD19 antigen, and wherein the antibody comprises the CDRs of the antibodies mR005-1 or mR005-2 whose amino acid sequences are depicted on the following table: