Patent ID: 6525061
Filing Date: 2003-02-25
Classification: C07D

Abstract:
A compound having the formula: wherein:R1 is phenyl optionally substituted with chloro, bromo, fluoro, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 2 to 6 carbon atoms, or alkoxy of 1 to 6 carbon atoms, straight chain alkyl of 1 to 6 carbon atoms optionally substituted with hydroxyl, amino, guanidino, thiol, phenyl, substituted phenyl, COOH, or CONH2, or branched chain alkyl of 3 to 7 carbon atoms, optionally substituted with hydroxyl, amino, guanidino, thiol, phenyl, substituted phenyl, COOH, or CONH2; R2 is hydrogen, fluoro, chloro, bromo, nitro, straight chain alkyd of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenyl substituted with fluoro, chloro, bromo, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkoxy of 1 to 6 carbon atoms, or methylenedioxy; R3 is hydrogen, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, straight chain alkenyl of 2 to 6 carbon atoms, branched chain alkenyl of 3 to 9 carbon atoms, straight chain alkynyl of 3 to 9 carbon atoms, branched chain alkynyl of 4 to 9 carbon atoms, phenylalkyl of 7 to 12 carbon atoms, phenyl or acyl; and R4 is hydroxy, alkoxy of 1 to 6 carbon atoms or amino; and pharmaceutical salts thereof with the proviso that when R1 is phenyl and R3 is hydrogen, R2 is not hydrogen.