Patent ID: 6420549
Filing Date: 2002-07-16
Classification: C07H,C12N,C12Q,Y02P

Abstract:
A compound having Formula: wherein:Z is a covalent intersugar linkage selected from the group consisting of 3â€²-CH2â€”NHâ€”Oâ€”, 3â€²-CH2â€”N(CH3)â€”Oâ€”, 3â€²-amino phosphoramidate, and 3â€²-amino phosphorothioamidate; each T1 and T2 is, independently, â€”OH, â€”OR1, â€”CH2R1, â€”NH(R1), â€”SH, â€”SR1, or a blocked hydroxyl; R1 is C1-C12 alkyl; BX is a heterocyclic base; X is F, â€”Oâ€”R, â€”Sâ€”R or â€”NR(R2); R is alkyl, or a ring system having from about 4 to about 7 carbon atoms or having from about 3 to about 6 carbon atoms and 1 or 2 hetero atoms wherein said hetero atoms are selected from oxygen, nitrogen and sulfur and wherein said ring system is aliphatic, unsaturated aliphatic, aromatic or heterocyclic; and wherein any available hydrogen atom of said ring system is each replaceable with an alkoxy, alkylamino, urea or alkylurea group; or R has one of the formulas: â€ƒwherein Q is O, S or NR2; m is from 1 to 10; y is from 0 to 10; E is N(R2)(R3), N&boxH;C(R2)(R3), C1-C10 alkyl, or C1-C10 substituted alkyl wherein said substituent is N(R2)(R3); and each R2 and R3 is, independently, H, C1-C10 alkyl, alkylthioalkyl, a nitrogen protecting group, or R2 and R3, together, are a nitrogen protecting group or wherein R2 and R3 are joined in a ring structure that can include at least one heteroatom selected from N and O.