Patent ID: 6228865
Filing Date: 2001-05-08
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR226##or a pharmaceutically acceptable salt or solvate thereof, wherein:a represents N or NO--;R.sup.1 and R.sup.3 are the same or different halo atom;R.sup.2 and R.sup.4 are selected from H and halo, provided that at least one of R.sup.2 and R.sup.4 is H;the dotted line {character pullout} represents an optional bond;X is C when the optional bond is present, or CH when the optional bond is absent;T is a substituent selected from: ##STR227##wherein:A represents --(CH.sub.2).sub.b --;B represents --(CH.sub.2).sub.d --;b and d are independently selected from: 0, 1, 2, 3, or 4 such that the sum of b and d is 4; andY is selected from: O; ##STR228##wherein:D represents --(CH.sub.2).sub.e --;E represents --(CH.sub.2).sub.f --;e and f are independently selected from: 0, 1, 2, or 3 such that the sum of e and f is 2 or 3; andZ is O; ##STR229##wherein:F represents --(CH.sub.2).sub.g --;G represents --(CH.sub.2).sub.h --;U represents --(CH.sub.2).sub.i --;h represents 1, 2, or 3g and i are independently selected from: 0, 1 or 2 such that the sum of h, g and i is 2 or 3; andV and W are independently selected from O, S, SO, or SO.sub.2 ; ##STR230##wherein:the dotted line {character pullout} represents an optional bound;k is 1 or 2 such that when the optional bond is present k represents 1, and when the optional double bond is absent then k represents 2;R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are the same alkyl; orR.sup.5 and R.sup.7 are the same alkyl, and R.sup.6 and R.sup.8 are H; ##STR231##wherein:the dotted lines {character pullout} represent optional bonds 1 and 2 such that optional bonds 1 and 2 are both present, or optional bonds 1 and 2 are both absent;Y represents O; ##STR232##wherein:Y represents O; ##STR233##wherein:R.sup.9 is selected from: --CN, --CO.sub.2 H, or --C(O)N(R.sup.10).sub.2 ;Y represents O:each R.sup.10 is the same or different alkyl group; ##STR234##wherein:I represents --(CH.sub.2).sub.m --;m represents 3;Y represents O; andR.sup.11 represents alkyl.