Patent ID: 6566362
Filing Date: 2003-05-20
Classification: A61P,C07D

Abstract:
A benzo[f]naphthyridine compound chosen from benzo[f]naphthyridine compounds of formula (I), stereoisomers thereof, mixtures of stereoisomers thereof, metal salts thereof, nitrogenous base addition salts thereof, and acid addition salts thereof: wherein R1, R2, and R3, which are identical or different, are chosen from a hydrogen atom, halogen atoms, and groups of formula (II): â€ƒwherein: R5 and R6 form, together with the nitrogen atom to which they are attached, a 5-, 6-, or 7-membered heterocycle, wherein 2 carbon atoms are optionally linked to each other by a bridge containing 1 or 2 carbon atoms, wherein said heterocycle optionally contains, in addition to said nitrogen atom, a heteroatom chosen from nitrogen, oxygen, and sulphur, and wherein said heterocycle is optionally substituted with at least one group chosen from (i) an unsubstituted phenyl group, (ii) a phenyl group substituted with at least one group chosen from halogen atoms, alkyl groups, haloalkyl groups, allyloxy groups, and a benzyloxy group, (iii) a benzyl groups (iv) alkyl groups, (v) a hydroxyl group, (vi) aminoalkyl groups, (vii) alkylaminoalkyl groups, (viii) dialkylaminoalkyl groups, and (ix) benzylaminoalkyl groups, provided that at least one of said R1, R2, and R3 is a group of formula (II), and provided that at least one of said R1, R2, and R3 is chosen from halogen atoms, and R4 is chosen from alkyl groups, fluoroalkyl groups, carboxyalkyl groups, (C3 to C5) cycloalkyl groups, a fluorophenyl group, a difluorophenyl group, alkyloxy groups, and alkylamino groups, wherein each of the foregoing alkyl groups are chosen from unbranched (C1 to C4) alkyl groups and branched (C1 to C4) alkyl groups.