Patent ID: 7452883
Filing Date: 2008-11-18
Classification: A61K,A61P,C07D

Abstract:
1. A method for inhibiting the formation of advanced glycosylation end products (AGE) in a patient that has and is being treated for atherosclerosis and/or Alzheimer's disease, comprising: administering to said patient in need thereof an effective amount of a compound of formula (I) in which: R1 and R2 are chosen independently from the groups: wherein R3 and R4 are chosen independently from the groups: R3 and R4 can form with the nitrogen atom an n-membered ring (n between 3 and 8) optionally comprising one or more heteroatoms chosen from N, O, S, R5 and R6 are chosen independently from the groups:  wherein R5 and R6 can form with the carbon atom to which they are attached an m-membered ring (m between 3 and 8) optionally comprising one or more heteroatoms chosen from N, O, S and being capable of being substituted with hydroxyl, (C  wherein when R1 and R2 represent a hydrogen, or R3 and R4 represent a hydrogen, then R3 and R4 or R1 and R2 are defined as above with the exception of hydrogen, or a form selected from the group consisting of tautomeric, enantiomeric, diastereoisomeric and epimeric or the pharmaceutically acceptable salt thereof.