Patent ID: 7105180
Filing Date: 2006-09-12
Classification: A61K

Abstract:
1. An oral pharmaceutical formulation comprising a benzimidazole compound of the formula I wherein R1 is hydrogen, methoxy or difluoromethoxy, R2 is hydrogen, methyl or methoxy, R3 is methoxy, 2,2,2-trifluoroethoxy or 3-methoxypropoxy, and R4 is hydrogen, methyl or methoxy, comprising (a) an inert core; (b) thereon, an active ingredient layer comprising the benzimidazole compound of the formula I mixed with an acidic reacting compound said active ingredient layer containing no alkaline reacting compound; (c) at least one inert layer; and (d) an outer layer, comprising an enteric coating, applied to the inert layer wherein an aqueous suspension of the active ingredient layer provides a pH of less than 7.