Patent ID: 8063206
Filing Date: 2011-11-22
Classification: C07D

Abstract:
1. A process for the preparation of a compound of formula (II) or a hydrate or pharmaceutically acceptable salt, ester or amide thereof; wherein p is an integer selected from 1 and 2; R q is an integer selected from 0, 1 and 2; each R R each R R R alternatively, R each R comprising reacting a compound of formula (XXIII) with a source of bisulfite; in a polar organic solvent; to yield the corresponding bisulfite, the compound of formula (XXVII); reacting the compound of formula (XXVII) with a compound of formula (XXIV); in the presence of a reducing agent; in the presence of an organic or inorganic base; in an organic solvent; to yield the corresponding compound of formula (II); wherein the compound of formula (XXIV) is present in an amount greater than one equivalent; and optionally reacting the compound of formula (II) to yield the corresponding hydrate or pharmaceutically acceptable salt, ester or amide of the compound of formula (II).