Patent ID: 6613944
Filing Date: 2003-09-02
Classification: C07B,C07C,C07D

Abstract:
A process for the preparation of an (S)-3-carbon amino alcohol salt of the formula (V)X2â€”CH2â€”C*H(OH)â€”CH2â€”NH3+â€ƒâ€ƒ(V) where:(I) X2 is: (A) â€”Cl, (B) â€”Br, (C) p-CH3â€”&phgr;SO2â€”, (D) m-NO2â€”&phgr;SO2â€” which comprises: (1) contacting phthalimide (VI) with an (S)-protected-epoxide of formula (III)X2â€”CH2â€”C*#Hâ€”CH2â€”O#â€”â€ƒâ€ƒ(III) in the presence of potassium phthalimide in DMF or DMAC where:(I) # indicates that the atoms marked with a (#) are bonded to each other resulting in the formation of a ring; (II) X2 is as defined above; to give an (S)-phthalimide alcohol of formula (IVC) â€ƒwhere X2 is as defined above and (2) contacting the product of step (1) with aqueous acid.