Patent ID: 6130235
Filing Date: 2000-10-10
Classification: A61P,C07D

Abstract:
A compound of the formula: ##STR21## and the pharmaceutically acceptable salts thereof wherein Ar.sup.1 is indole, benzimidazole, or benzotriazole, optionally substituted with lower alkyl (1-4C), halo, or lower alkoxy (1-4C);when Ar.sup.1 is benzimidazole, Ar.sup.1 is coupled to X.sup.1 through the 3, 4, 5, or 6 position;when Ar.sup.1 is indole, Ar.sup.1 is coupled to X.sup.1 through the 5 or 6 position;X.sup.1 is CO, SO, SO.sub.2 or CHOH;Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl;n is 0 or 1;Z is CH;X.sup.2 is CH, X.sup.1 ; andAr.sup.2 consists of one or two phenyl moieties directly coupled to X.sup.2 and optionally substituted by halo, nitro, alkyl (1-6C), CN or CF.sub.3, or by RCO, COOR, CONR.sub.2, NR.sub.2, OR or SR, wherein R is H or alkyl (1-6C) or by phenyl, itself optionally substituted by the foregoing substituents.