Patent ID: 6583163
Filing Date: 2003-06-24
Classification: A61K,A61P,Y10S

Abstract:
A method for inhibiting adhesion of neutrophils to vascular endothelial cells by administering to a patient in need thereof an agent for inhibiting adhesion of neutrophils to vascular endothelial cells comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula: wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the pheny ring; and R2 is a group represented by the formula: â€ƒwherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by â€”(A)lâ€”NR4R5 (wherein A is a lower alkylene group; R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group; and l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.