Patent ID: 7166708
Filing Date: 2007-01-23
Classification: A61K,A61P,Y02A,Y10S

Abstract:
1. A process for preparing a hapten-protein-polysaccharide conjugate comprising: a) reacting a protein with a hapten to produce at least a hapten-protein conjugate, and any unreacted protein and any unreacted hapten; b) reacting the hapten-protein conjugate with a polysaccharide to produce at least a hapten-protein-polysaccharide conjugate, and unreacted hapten-protein conjugate; c) removing at least one unreacted hapten or low-molecular weight component from the mixture without removing unreacted protein or unreacted hapten-protein conjugate, if present, to provide a purified mixture that contains the hapten-protein-polysaccharide conjugate and at least one of unreacted protein and unreacted hapten-protein conjugate, to thereby provide a conjugate mixture including the hapten-protein-polysaccharide conjugate, and at least one of hapten-protein conjugate and unreacted protein.