Patent ID: 7534561
Filing Date: 2009-05-19
Classification: B01J,B82Y,C12Q,C40B

Abstract:
1. A method of producing a nucleic acid microarray comprising two or more different nucleic acids immobilized at different locations on a surface, said method comprising: (a) identifying a collection of feature locations of the nucleic acid microarray in which to produce control probes during synthesis of the nucleic acid microarray using an in situ microarray synthesis protocol, wherein said protocol utilizes a pulse-jet fluid deposition device having a total number of nozzle groups Y that traverse an entire array surface in one or more passes during said protocol, wherein each pass of said protocol is made up of a total number of swaths Z, and wherein said collection of feature locations samples less than all of said nozzle groups Y in any given swath but all of said nozzle groups Y in said total number of swaths Z of any given pass; and (b) producing said nucleic acid microarray using said in situ microarray synthesis protocol, wherein said control probes are produced in said collection of feature locations.