Patent ID: 8980303
Filing Date: 2015-03-17
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition, comprising: an antimycotic component and a prebiotic component, wherein the pharmaceutical composition is effective for prevention and treatment of vaginosis, vaginitis and vulvovaginitis in a dosage form suitable for local application; wherein the antimycotic component comprises one or more compound selected from the group consisting of terconazole, tioconazole, butoconazole, ketoconazole, clotrimazole, miconazole, omoconazole, fenticonazole, oxiconazole, bifonazole, econazole, isoconazole, naftifine, terbinafine, amphotericin B, natamycin, nystatin, levorin, nifuratel, furazolidone, and their pharmaceutically acceptable combinations; and wherein the prebiotic component is lactulose present in pharmaceutically acceptable concentrations, mixed in the composition such that the composition comprises, in weight/volume concentrations per composition mass: (i) antimycotic, from 0.0001% to 5%; (ii) lactulose, from 0.1% to 40%; (iii) the balance: dosage form base and/or excipients wherein said composition is both water and lipid soluble; wherein the pharmaceutical composition further comprises PEG (polyethylene glycol) and/or Witepsol as a base; wherein the pharmaceutical composition further comprises Cremophor RH40 as a solubilizing agent.