Patent ID: 6063801
Filing Date: 2000-05-16
Classification: A61P,C07D

Abstract:
A compound of formula I: ##STR7## wherein R.sub.1 and R.sub.2 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, trifluoromethoxy, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylthio, (C.sub.1 -C.sub.6)alkanoyloxy, aryl, or aryl(C.sub.1 -C.sub.6)alkyl; or R.sub.1 and R.sub.2 taken together are methylenedioxy; or R.sub.1 and R.sub.2 taken together are benzo;R.sub.3, R.sub.4, and R.sub.5 are each independently selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.2 -C.sub.6)alkanoyloxy, aryl, and aryl(C.sub.1 -C.sub.6)alkyl;R.sub.6 and R.sub.7 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, trifluoromethoxy, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylthio, or (C.sub.1 -C.sub.6)alkanoyloxy;R.sub.8 is hydroxy, halo, nitro, cyano, mercapto, carboxy, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkoxy, --NR.sub.a R.sub.b, halo(C.sub.1 -C.sub.6)alkyl, trifluoromethoxy, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylthio, (C.sub.1 -C.sub.6)alkanoyloxy, or aryloxy; or R.sub.8 is (C.sub.1 -C.sub.6)alkyl substituted by 1, 2, or 3 substituents independently selected from the group consisting of hydroxy, nitro, cyano, mercapto, carboxy, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkoxy, --NR.sub.a R.sub.b, trifluoromethoxy, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylthio, (C.sub.1 -C.sub.6)alkanoyloxy, and aryloxy; andeach R.sub.a and R.sub.b is independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, aryl, aryl(C.sub.1 -C.sub.6)alkyl, or arylcarbonyl;wherein each aryl independently represents a phenyl radical or an ortho-fused bicyclic carbocyclic radical having nine or ten ring atoms in which at least one ring is aromatic; andwherein any aryl or benzo of R.sub.1 -R.sub.5, R.sub.8, R.sub.a, and R.sub.b may optionally be substituted by 1, 2, or 3 substituents independently selected from the group consisting of (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)cycloalkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.6)alkoxy, hydroxy, halo, nitro, cyano, mercapto, carboxy, hydroxy(C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, trifluoromethoxy, (C.sub.1 -C.sub.6)alkanoyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, (C.sub.1 -C.sub.6)alkylthio, and (C.sub.1 -C.sub.6)alkanoyloxy;or a pharmaceutically acceptable salt thereof.