Patent ID: 6635653
Filing Date: 2003-10-21
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein W is hydrogen, C1-10 alkyl, C3-12 cycloalkyl, C3-12 cycloalkylC1-4alkyl-, C1-10 alkoxy, C3-12 cycloalkoxy, C1-10 alkyl substituted with 1-3 halogen, C3-12 cycloalkyl substituted with 1-3 halogen, C3-12 cycloalkylC1-4alkyl-substituted with 1-3 halogen, C1-10 alkoxy substituted with 1-3 halogen, C3-12 cycloalkoxy-substituted with 1-3 halogen, â€”COOV1, â€”C1-4COOV1, â€”CH2OH, â€”SO2N(V1)2, hydroxyC1-10alkyl-, hydroxyC3-10cycloalkyl-, cyanoC1-10alkyl-, cyanoC3-10cycloalkyl-, â€”CON(V1)2, NH2SO2C1-4alkyl-, NH2SOC1-4alkyl-, sulfonylaminoC1-10alkyl-, diaminoalkyl-, -sulfonylC1-4alkyl, a 6-membered aromatic ring, a 6-membered aromaticC1-4 alkyl-, â€”C1-5(&boxH;O)W1, â€”C1-5(&boxH;NH)W1, â€”C1-5NHC(&boxH;O)W1, â€”C1-5NHS(&boxH;O)2, W1, â€”C1-5NHS(&boxH;O)W1, wherein W1 is hydrogen, C1-10 alkyl C3-12 cycloalkyl, C1-10 alkoxy, C3-12 cycloalkoxy, â€”CH2OH, amino, C1-4alkylamino-, or diC1-4alkylamino-; wherein each V1 is independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, benzyl or phenyl, provided that V1 is a C3-6 cycloalkyl, benzyl or phenyl whjen a substituent of R1; Q is a 6 membered aromatic group; n is an integer from 0 to 3; A, B and C are hydrogen; Z is selected from the group consisting of a bond, methyl or ethyl; R1 is selected from the group consisting of C3-12 cycloalkyl, C3-12cycloalkylamino-, â€”COOV1, â€”C1-4COOV1, cyanoC3-10cycloalkyl-, benzyl, C3-12 cycloalkenyl-, a monocyclic, bicyclic or tricyclic aryl, and a spiro ring system of the formula (II): â€ƒwherein X1 and X2 are CH2; and wherein said cycloalkyl, C3-12cycloalkylamino-, or benzyl of R1 is optionally substituted with 1-3 substituents selected from the group consisting of halogen, hydroxy, C1-10 alkyl, C1-10 alkoxy, nitro, trifluoromethyl-, cyano, â€”COOV1, â€”C1-4COOV1, cyanoC1-10alkyl-, â€”C1-5&boxH;OW1, â€”C1-5NHS(&boxH;O)2W1, â€”C1-5NHS(&boxH;O)W1, phenyl, benzyl, benzyloxy, said phenyl, benzyl, and benzyloxy optionally being substituted with 1-3 substituents selected from the group consisting of halogen, C1-10 alkyl-, C1-10 alkoxy-, and cyano; and wherein said C3-12 cycloalkyl, C3-12 cycloalkenyl, monocyclic, bicyclic or tricyclic aryl, or spiro ring system of the formula (II) is optionally substituted with 1-3 substituents selected from the group consisting of halogen, C1-10 alkyl, C1-10 alkoxy, nitro, trifluoromethyl-, phenyl, benzyl, phenyloxy and benzyloxy, wherein said phenyl, benzyl, phenyloxy or benzyloxy is optionaly substituted with 1-3 substituents selected from the group consisting of halogen, C1-10 alkyl, C1-10 alkoxy, and cyano; R2 is selected from the group consisting of hydrogen, C1-10 alkyl, C3-12 cycloalkyl and halogen, said alkyl or cycloalkyl optionally substituted with an oxo, amino, alkylamino or dialkylamino group; or a pharmaceutically acceptable salt thereof or solvate thereof.