Patent ID: 6514944
Filing Date: 2003-02-04
Classification: C07H

Abstract:
A compound of the formula whereinRa is substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl; substituted or unsubstituted arylalkyl; or ORa is replaced by H; Rb is H or halogen; Rc is H or a protecting group; Rdâ€² is H, substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (3-10C); substituted or unsubstituted arylalkyl (4-10C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group; L is methylene or carbonyl; T is â€”Oâ€”, â€”N(R)â€”, or â€”N(OR)â€”, â€”N(NHCOR)â€”, â€”N(N&boxH;CHR)â€”, or â€”N(NHR)â€” wherein R is H or Ra as defined above, with the proviso that when L is methylene, T is â€”Oâ€”; one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or Z and Y together are &boxH;O, &boxH;NOH or a derivatized oxime; or a pharmaceutically acceptable salt thereof or a stereoisomeric form or a mixture of stereoisomeric forms thereof.