Patent ID: 7939111
Filing Date: 2011-05-10
Classification: A23L,A61K,A61P,A61Q

Abstract:
1. A composition comprising: a first extract of lingonberry fruit, said first extract comprised of 5-20 wt % of anthocyanin, 50-95 wt % of proanthocyanin, less than 2 wt % of resveratrol, and the balance of other components, and a second extract of lingonberry fruit, said second extract comprising 60-98 wt % of resveratrol, wherein said first extract of lingonberry fruit is obtained by: (a) extracting lingonberry fruit with a first solvent, said first solvent being an aqueous acid solution or an aqueous acid-alcohol solution containing no more than 10 wt % of hydrochloric acid, sulfuric acid, acetic acid or citric acid, or an aqueous solution containing 0.05-0.2 wt % of cellulase or pectinase; (b) evaporating said first extract solution to obtain a crude first extract; and (c) purifying said crude first extract to obtain a said first extract, wherein said purifying comprises: to form said first extract; and wherein said second extract of lingonberry fruit is obtained by steps of: (d) re-extracting the extracted lingonberry fruit of step (a) with a second solvent to obtain a second extract solution, wherein said second solvent is ethyl acetate, benzene, toluene, chloroform, dichloromethane, n-hexane, acetone, methanol, ethanol, or a mixture thereof, or 70-95 wt % methanol or ethanol aqueous solution, or an enzyme aqueous solution containing 0.01-0.3 wt % of cellulase or pectase; (e) concentrating said second extract solution to obtain a crude second extract; and (f) purifying said crude second extract using silica gel column chromatography with n-hexane, ethyl acetate, acetone, chloroform, dichlormethane, methanol, ethanol, or a mixture thereof as the eluent, to form said second extract, and wherein said first extract and said second extract are combined to form said composition.