Patent ID: 6452006
Filing Date: 2002-09-17
Classification: C07D

Abstract:
A process for the preparation of 5-(1-methyethyl)-6-(phenylmethyl)pyrimidine-2,4-(1H,3H)-dione of formula (I): comprising the steps of reacting a compound of formula (VI): by coupling, in the presence of a homogeneous metal catalyst, either with an organometallic compound of formula (V): in which M represents an alkali metal or other metal of Group II or Group III of the periodic table, and X represents a halogen atom, or with a benzyl halide in the presence of magnesium,to obtain a compound of formula (IV): and, where R1 is OR2 or a halogen atom, subjecting the compound of formula (IV) to acid hydrolysis, or where R1 is a halogen atom, subjecting the compound of formula (IV) to dialkoxylation followed by acid hydrolysis, to obtain the compound of formula (I).