Patent ID: 6407086
Filing Date: 2002-06-18
Classification: A61P,C07J

Abstract:
A method of regulating meiosis comprising administering to a subject in need thereof an effective amount of the compound of formula Ic: wherein R1 is hydrogen, halogen, methyl, hydroxyl or oxo; R2 is selected from the group consisting of hydrogen, hydroxyl, C1-C3 alkyl, vinyl, C1-C3 alkoxy and halogen; R3 is selected from the group consisting of optionally substituted alkoxy, acyloxy, sulphonyloxy, and phosphonyloxy; Râ€²3 designates hydrogen or hydroxyl; R4 and Râ€²4, which are different or identical with the proviso that they are not both hydroxyl, are selected from the group comprising hydrogen, halogen, hydroxyl and C1-C6 alkyl which may be substituted by halogen, hydroxyl or cyano; R5 is hydrogen, halogen, hydroxyl, lower alkyl, cyano, hydroxymethyl, a carbaldehyde, an oxime derived from a carbaldehyde, a carboxylic acid, a primary or secondary amide derived from a carboxylic acid or an ester with a C1-C6-alcohol group; R6 is hydrogen, hydroxyl, halogen or oxo; R7 is selected form the group consisting of hydrogen, hydroxyl, lower alkoxy, acyloxy, halogen and lower alkyl; Râ€²7 is hydrogen, or, if R7 is lower alkyl, Râ€²7 is hydrogen or hydroxyl; R8 designates together with R9 an additional bond between the carbon atoms at which R8 and R9 are placed; R11 is selected from the group consisting of hydrogen, hydroxyl, lower alkoxy, acyloxy, halogen and lower alkyl; Râ€²11 is hydrogen or, if R11 is lower alkyl, Râ€²11 is hydrogen or hydroxyl; R12 is selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, methylene, hydroxyl, lower alkoxy, acyloxy, oxo and a group of the general formula &boxH;NOR33 wherein R33 is hydrogen or C1-C3 alkyl; R14 designates together with R15 an additional bond between the carbon atoms at which R14 and R15 are placed; R16 is selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, methylene, hydroxyl, lower alkoxy, oxo and a group of the general formula &boxH;NOR34 wherein R34 is hydrogen or lower alkyl; R17 is hydrogen or hydroxyl; R20 is selected from the group consisting of hydrogen, lower alkyl and hydroxymethyl or R20 and Râ€²20 together designate methylene or oxo; Râ€²20 is hydrogen, halogen, lower alkyl or hydroxyl; Râ€²22 is hydrogen, hydroxyl or oxo; R22 is cyclohexyl or cyolohexylalkyl, each optionally substituted by one or more of the following groups which substituents may be different or identical: hydroxyl, lower alkoxy, halogen, amino, cyano, carboxy, a group of the general formula â€”COOR39, oxo, N-alkylamino or N,N-dialkylamino wherein the N-alkylamino or N,N-dialkylamino substituent optionally is substituted by carboxy, lower alkoxy or lower alkylthio; and wherein R39 is lower alkyl or aralkyl.