Patent ID: 7560451
Filing Date: 2009-07-14
Classification: A61P,C07D,C07F

Abstract:
1. A compound having the structural formula or an isomer, pharmaceutically acceptable salt of said compound or said isomer, wherein W is —S(O)—, —S(O) R R or optionally, any two of R a) a 3- to 8-membered cycloalkyl ring optionally substituted by 1 to 5 R b) 1-4 of the atoms in the above 3-8 membered cycloalkyl ring can be replaced by —O—, —S—, —N(R R R R R R R R wherein R 23 numbers 0 to 5 substituents, m is 0 to 6 and n is 1 to 5; R or two R R R and wherein each of the arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylaryl, heterocycloalkenylaryl groups in R or two R and when R R R R R R wherein “heteroaryl” means a group selected from pyridyl, pyrazinyl, furanyl, thienyl, pyrimidinyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, pyrrolyl, pyrazolyl, triazolyl, 1,2,4-thiadiazolyl, pyrazinyl, pyridazinyl, quinoxalinyl, phthalazinyl, imidazo[1,2-a]pyridinyl, imidazo[2,1 -b]thiazolyl, benzofurazanyl, indolyl, azaindolyl, benzimidazolyl, benzothienyl, guinolinyl, imidazolyl, thienopyridyl, quinazolinyl, thienopyrimidyl, pyrrolopyridyl, imidazopyridyl, isoquinolinyl, benzoazaindolyl, 1,2,4-triazinyl, and benzothiazolyl, wherein “heterocycloalkyl” means a group selected from piperidyl, pyrrolidinyl, piperazinyl, morpholinyl, thiomorpholinyl, thiazolidinyl, 1,3-dioxolanyl, 1,4-dioxanyl, tetrahydrofuranyl, tetrahydrothiophenyl, and tetrahydrothiopyranyl, and wherein “cycloalkyl” means a mono or multicyclic group selected from cyclopropyl, cyclopentyl, cyclohexyl, cycloheptyl, 1-decalin, norbornyl, adamantyl,