Patent ID: 7247625
Filing Date: 2007-07-24
Classification: A61K,C07D

Abstract:
1. A progesterone receptor modulator having the formula: wherein: R R R or R (i) 3 to 8 membered saturated spirocyclic ring; (ii) 3 to 8 membered spirocyclic ring having in its backbone one or more carbon-carbon double bonds; or (iii) 3 to 8 membered saturated spirocyclic ring having in its backbone one to three heteroatoms selected from the group consisting of O, S, and N; R R R Q is O, S, NR R R or CR R X is O; or a pharmaceutically acceptable salt, or tautomer thereof; wherein: said substituted alkyl, substituted alkenyl, and substituted alkynyl is an alkyl, alkenyl, and alkynyl, respectively, comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted aryl is an aryl comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted cycloalkyl is a cycloalkyl comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted alkoxy is an alkoxy comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted aminoalkyl is an aminoalkyl comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted heterocyclic is a heterocycle comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted aryloxy is an aryloxy comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO said substituted thioalkoxy is a thioalkoxy comprising one or more substituents selected from the group consisting of halogen, CN, OH, NO