Patent ID: 6313180
Filing Date: 2001-11-06
Classification: A61P,C07J

Abstract:
A steroid compound having the formula ##STR3##whereinR.sub.3 is .dbd.O; --OH; .dbd.NOR; --OR or OOCR, in which R is an alkyl group having 1 to 6 carbon atoms;R.sub.6 is H; .dbd.CH.sub.2 or --(CH.sub.2).sub.m H with m is 1 or 2;R.sub.7 is H; C.sub.1-4 -alkyl; C.sub.2-5 -alkenyl or C.sub.2-5 -alkynyl, wherein the alkyl, alkenyl or alkynyl group may be substituted with 1 to 3 halogen atoms independently selected from the group consisting of fluorine and chlorine atoms;R.sub.11 is H;E represents, together with carbon atoms 16 and 17 of ring D, a four to seven-membered ring, said ring being .alpha. with respect to the D-ring, substituted with R.sub.E and optionally comprising one or two endocyclic double bonds;R.sub.E is H; C.sub.1-6 -alkyl; C.sub.2-6 -alkenyl; C.sub.2-6 -alkynyl; C.sub.1-6 -alkylidene; C.sub.2-6 -spiro-anellated cycloalkyl; --OR'; --SR'; --OOCR'; --NHR'; --NR'R'; --NHCOR', wherein R' (and in the case of R.sub.E being --NR'R' each R' independently of the other) is an alkyl with 1 to 6 carbon atoms; --NCO; --(CH.sub.2).sub.n --N.sub.3 or --(CH.sub.2).sub.n --CN, with n is 0 to 5, wherein the alkyl, alkenyl, alkynyl, alkylidene or cycloalkyl group may be substituted with 1 to 3 substituents independently selected from the group consisting of --OR'; --SR'; --OOCR'; --NHR'; --NR'R'; --NHCOR', with R' being defined as above; fluorine atoms and chlorine atoms;R.sub.17 is --OH; --OCH.sub.2 OR; --OR or --OOCR wherein R is an alkyl with 1 to 6 carbon atoms; wherein the steroid compound optionally may have one or more double bonds chosen from the group of .DELTA.9(10); .DELTA.5(10); .DELTA.4(5); .DELTA.11(12); .DELTA.14(15); or any of the rings A or B may be aromatic.