Patent ID: 6506582
Filing Date: 2003-01-14
Classification: A61K,A61P,C07K

Abstract:
An isolated nucleic acid encoding a polypeptide with interleukin-16 (IL-16) activity, wherein the IL-16 activity is at least one activity selected from the group consisting of (1) binding to T cells via the CD4 receptor, (2) stimulating the expression of the IL-2 receptor and/or HLA-DR antigen on CD4* lymphocytes, (3) stimulating the proliferation of T helper cells in the presence of IL-2, (4) suppressing the proliferation of T helper cells stimulated with anti-CD3 antibodies, and (5) suppressing the replication of viruses, wherein the nucleic acid sequence is selected from the group consisting of(A) the nucleic acid sequence of SEQ ID NO:1, (B) the nucleic acid sequence if SEQ ID NO:1 extended at the 5â€²-end by an aspartic acid codon, and (C) the nucleic acid sequence of SEQ ID NO:1 shortened at the 3â€²-end by 1 to 8 amino acid codons.