Patent ID: 6376472
Filing Date: 2002-04-23
Classification: A61P,C07D,C07H

Abstract:
A compound of the formula: wherein:K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methyl allyl, 2-butenyl, or cycloalkyl; X is: where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, hetereocyclylalkyl, or substituted heterocyclylalkyl, said heterocyclyl having from 4 to 10 ring members comprising one or more heteroatoms selected from the group consisting of N, O and S; and n and p are independently with 0, 1, 2, or 3, provided that n+p is at least 1; T is hydrogen, alkyl, alkyl carbonyl, alkyl thiocarbonal, halo, carboxyl or R3Oâ€”CH2; R1, R2 and R3 are independently H, alkyl or cycloalkyl; A is hydrogen, alkyl, hydroxyalkyl, alkoxyaokyl, or ORâ€²; B is hydrogen, alkyl, hydroxyalkyl, alkoxyaokyl, or ORâ€³; Râ€² and Râ€³ are independently hydrogen, alkyl, aralkyl,carbamoyl; alkyocarbamoyl, dialkylcarbamoyl, alkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl; aryloxycarbonyl, or, when A or B are ORâ€² and ORâ€³, respectively, Râ€² and Râ€³ together may form where Rc is hydrogen or alkyl, where Rd and Re are independently hydrogen, alkyl, or together with the carbon atom to which they are attached may form a 1,1-cycloalkyl group;or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable pro drug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.