Patent ID: 6355633
Filing Date: 2002-03-12
Classification: A61P,C07C,C07D

Abstract:
A method of providing contraception in a female mammal in need thereof which comprises administering to said mammal a contraceptive effective amount of a compound of formula I having the structure whereinQ is hydrogen or â€”SO2R1; X is a bond, O, S(O)n, â€”CH&boxH;CHâ€”, â€”CH2CH2â€”, CHâ€”, â€”Câ‰¡Câ€”, or â€”CH2S(O)nCH2â€”; R1 is OH, NH2, C1 to C6 alkoxy, C1 to C3 perfluoroalkoxy; R2 and R4 are each, independently, hydrogen, OR6, â€”S(O)mR6, â€”NHR6, â€”N(R6)2, or â€”CH2SO2CH3; R3 and R5 are each, independently, hydrogen, â€”NO2, â€”NH2, â€”SO2R9, or â€”CH2R9; R6 is hydrogen, C1 to C6 alkyl, C3 to C6 alkenyl, â€”CH2CH2Z, â€”CH2COR7, â€”CH2CH&boxH;CHCOR7, Y1 and Y3 are each, independently, N, or CH; Y2 and Y4 are each independently, O, S, or NR13; R7 is â€”OR8, â€”NHR8, â€”N(R8)2, or â€”NHCH2CH2OR8; Z is â€”OR8, â€”OCH2CH2OR8, â€”N(R8)2, or R8 is hydrogen, or C1 to C3 alkyl; R9 is C1 to C6 alkyl, C3 to C6 alkenyl, OH, NHR10, N(R10)2, CH2COR11, â€”CH2CH&boxH;CHCOR11, or R10 is C1 to C3 alkyl, C3 to C4 alkenyl, phenyl, â€”CH2CH2OCH3, or R11 is â€”OR12, â€”NHR12, â€”N(R12)2, or â€”NHCH2CH2OR12; R12 is hydrogen, or C1 to C3 alkyl; R13 is hydrogen, or C1 to C3 alkyl; W is a bond, CH2, CH2CH2, O, S(O)q, NCHO, NCOCH3, or NR12; m is 0-2; n is 0-2; q is 0-2, with the proviso that R2 and R3 are not both hydrogen; or pharmaceutically acceptable salt thereof.