Patent ID: 8865752
Filing Date: 2014-10-21
Classification: A61P,C07D

Abstract:
1. A method for the treatment or lessening of the severity of a disease selected from fibrosis, cirrhosis and prostate cancer, wherein treatment is effected by increasing ATRA, or decreasing androgen or estrogen levels, comprising administering to a subject in need thereof a compound or a pharmaceutical composition comprising a compound represented by Formula (I): or an E or Z isomer thereof, syn or anti isomer thereof, an optically pure isomer thereof, or pharmaceutically acceptable salt thereof, wherein: X is an unsaturated heterocycle selected from pyrrolyl, pyrazolyl, imidazolyl, triazolyl, benzimidazolyl, benzotriazolyl, tetrazolyl, thiazole, 3-pyridinyl or 4-pyridinyl, any of which is optionally substituted with one or more independent R R R or R G Y is a bond, hydrogen, halogen, an oxygen atom, sulfur atom, —CN, R Z is -aryl-, -arylalkyl-, -aryloxy-, -oxyaryl-, -arylalkenyl-, -alkenylaryl-, -hetaryl-, -hetarylalkyl-, -alkylhetaryl-, -hetarylalkenyl-, or -alkenylhetaryl-, any of which is optionally substituted with one or more independent halo, cyano, hydroxy, nitro, R Q R R R aryl-C n1, n2, n3, n4, n6, and n7 are each independently equal to 0, 1 or 2.