Patent ID: 6406839
Filing Date: 2002-06-18
Classification: A01N,A61K,A61P,Y10S

Abstract:
A method for increasing the circulating volume of a hypovolemic subject, the method of compromising;administering to said subject a physiologically compatible non-naturally occurring aqueous blood substitute solution comprising: (i) a macromolecular oncotic agent selected from the group consisting of cyclodextrins, polysaccharides and hydroxyethylstarch; (ii) Na+ in an amount ranging from 70 to 160 mM; (iii) Clâˆ’ in an amount ranging from 70 to 160 mM; (iv) K+ in an amount ranging from 0 to 5 mM; (v) Ca2+ in an amount ranging from about 0.5 to 4 mM; (vi) Mg2+ in an amount ranging from 0 to 10 mM; (vii) a simple sugar in a range from 2 to 10 mM; (viii) a dynamic buffering system comprising a carboxylic acid, salt or ester thereof of the formula: RCOOX â€ƒwhere: R is an alkyl, or aryl, branched or straight chained, containing 1 to 30 carbons, which carbons may be substituted; and X is hydrogen or sodium or other biologically compatible ion substituent which can attach at the oxygen position, or is a short straight or branched chain alkyl containing 1-4 carbons; wherein the blood substitute solution is terminally heat sterilized and does not include a conventional biological buffer.