Patent ID: 8163920
Filing Date: 2012-04-24
Classification: A61P,C07D

Abstract:
1. A process for preparing 1-isopropyl-2-oxo-1,2-dihydroquinoline -3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl -amino)propyl]-8-aza-bicyclo[3.2.1]oct-3-yl}amide (I″) the process comprising reacting 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-azabicyclo[3.2.1]oct-3-yl}amide (IV') with N-methyl-N-[(S)-2-oxiran-2-ylmethyl]methanesulfonamide (XI') to provide compound I″.