Patent ID: 7056500
Filing Date: 2006-06-06
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition, comprising: a polymer conjugate comprising a water soluble and non-peptidic polymer covalently attached to an opioid antagonist, wherein the molecular weight of the polymer is less than about 2,000 Da, and a pharmaceutically acceptable carrier a pharmaceutically acceptable carrier, wherein the polymer conjugate has the structure: wherein: POLY is the water soluble and non-peptidic polymer; X is a hydrolytically stable linkage; Y is selected from the group consisting of C1–C6 alkyl, substituted C1–C6 alkyl, C3–C6 cycloalkyl, substituted C3–C6 cycloalkyl, C2–C6 alkenyl, substituted C2–C6 alkenyl, alkenyl, C2–C6 alkynyl, substituted C1–C6 alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocylce, and substituted heterocycle; Z is H or OH; and, the dashed line represents an optional double bond.