Patent ID: 7253254
Filing Date: 2007-08-07
Classification: A61K,A61P,C07K

Abstract:
1. A bone morphogenetic protein (BMP) or a growth differentiation factor (GDF) polypeptide variant with increased heparin-binding ability, characterized in that (i) added to the amino acid sequence of a BMP or GDF polypeptide is at least one oligopeptide comprising the amino acid sequence X (ii) inserted into the amino acid sequence of a BMP or GDF polypeptide is at least one oligopeptide comprising the amino acid sequence X (iii) at least one oligopeptide sequence naturally occurring within the amino acid sequence of a BMP or GDF polypeptide is substituted by an oligopeptide comprising an amino acid sequence X wherein X X X X X X 6 =not K, R, H, but any other or no amino acid (SEQ ID NO: 1).