Patent ID: 7956183
Filing Date: 2011-06-07
Classification: A61K,A61P,C07D,Y02A

Abstract:
1. A method for the synthesis of a diaminophenothiazinium compound of the following formula: wherein: each of R each of R each of R X is one or more anionic counter ions to achieve electrical neutrality; which method comprises at least the following steps, in order: (a) purifying a corresponding acylated reagent compound of the following formula, wherein R 10 is independently a saturated aliphatic C 1-5 alkyl, phenyl, p-methoxyphenyl, or p-nitrophenyl: (b)(i) deacylating the acylated reagent compound (ARC) to give a corresponding deacylated compound of the following formula: (b)(ii) optionally purifying the deacylated compound; (c)(i) oxidizing the deacylated compound to give the diaminophenothiazinium compound; and (c)(ii) optionally purifying the diaminophenothiazinium compound.