Patent ID: 6573259
Filing Date: 2003-06-03
Classification: A61K,A61P,C07K,Y02A

Abstract:
A compound represented by formula (III): wherein:Y is C is pyrido, wherein any hydrogen bound to any ring atom is optionally replaced by â€”R4, R1 is -aryl, -heteroaryl, -alkylaryl, or -alkylheteroaryl, wherein each aryl or heteroaryl is optionally singly or multiply substituted with R17; R2 is a bond, â€”CH2C(O)â€”, â€”C(O)â€”, â€”C(O)C(O)â€”, â€”S(O)2â€”, â€”OC(O)â€”, â€”N(H)C(O)â€”, â€”N(H)S(O)2â€”, â€”N(H)C(O)C(O)â€”, â€”CH&boxH;CHC(O)â€”, â€”OCH2C(O)â€”, â€”N(H)CH2C(O)â€”, â€”N(R19)C(O)â€”, â€”N(R19)S(O)2â€”, â€”N(R19)C(O)C(O)â€”, â€”N(R19)CH2C(O)â€”, or â€”C(O)C(&boxH;NOR11)â€”, provided that when R2 is not a bond, R2 is bonded to the NH attached to the 7-membered ring through carbonyl or sulfonyl; R3 is -aryl, -heteroaryl, -cycloalkyl, -alkyl, â€”N(alkyl)2, R4 is â€”OH, â€”F, â€”Cl, â€”Br, â€”I, â€”NO2, â€”CN, â€”NH2, â€”CO2H, â€”C(O)NH2, â€”N(H)C(O)H, â€”N(H)C(O)NH2, -alkyl, -cycloalkyl, -perfluoroalkyl, â€”O-alkyl, â€”N(H) (alkyl), â€”N(alkyl)2, â€”C(O)N(H)alkyl, â€”C(O)N(alkyl)2, â€”N(H)C(O)alkyl, â€”N(H)C(O)N(H)alkyl, â€”N(H)C(O)N(alkyl)2, â€”S-alkyl, â€”S(O2)alkyl, â€”C(O)alkyl, â€”CH2NH2, â€”CH2N(H)alkyl, or â€”CH2N(alkyl)2; R5 is â€”OH, â€”OR8, or â€”N(H)OH; R6 is â€”H, â€”CH2OR9, â€”CH2SR10, â€”CH2NHR9, â€”CH2N(R9)R12, â€”C(H)N2, â€”CH2F, â€”CH2Cl, â€”C(O)N(R11)R12, â€”R13, or â€”R14; R8 is -alkyl, -cycloalkyl, -aryl, -heteroaryl, -alkylaryl, -alkylheteroaryl, or alkylheterocycle; R9 is â€”H, â€”C(O)aryl, â€”C(O)heteroaryl, â€”C(O)alkylaryl, â€”C(O)alkylheteroaryl, -alkylaryl, -alkylheteroaryl, -aryl, -heteroaryl, or â€”P(O)R15R16; R10 is -alkylaryl, -aryl, -heteroaryl, or -alkylheteroaryl; each R11 and R12 is independently â€”H, -alkyl, -aryl, -heteroaryl, -cycloalkyl, -alkylaryl, or -alkylheteroaryl; R13 is -alkylaryl, -alkenylaryl, -alkynylaryl, or -alkylheteroaryl; R14 is wherein any hydrogen bound to (i) is optionally replaced with R17 and any hydrogen bound to (ii) is optionally replaced with R17, R18 or R20; each R15 and R16 is independently â€”H, â€”OH, -alkyl, -aryl, -heteroaryl, -cycloalkyl, -alkylaryl, -alkylheteroaryl, â€”Oalkyl, â€”Oaryl, â€”Oheteroaryl, â€”Oalkylaryl, or â€”Oalkylheteroaryl; R17 is â€”OH, â€”F, â€”Cl, â€”Br, â€”I, â€”NO2, â€”CN, â€”NH2, â€”CO2H, â€”C(O)NH2, â€”N(H)C(O)H, â€”N(H)C(O)NH2, â€”S(O)2NH2, â€”C(O)H, -alkyl, -cycloalkyl, -perfluoroalkyl, â€”O-alkyl, â€”N(H)alkyl, â€”N(alkyl)2, â€”CO2alkyl, â€”C(O)N(H)alkyl, â€”C(O)N(alkyl)2, â€”N(H)C(O)alkyl, â€”N(H)C(O)N(H)alkyl, â€”N(H)C(O)N(alkyl)2, â€”S(O)2N(H)alkyl, â€”S(O)2N(alkyl)2, â€”S-alkyl, â€”S(O2)alkyl, or â€”C(O)alkyl; R18 is -aryl, -heteroaryl, -alkylaryl, -alkylheteroaryl, â€”O-aryl, â€”O-heteroaryl, â€”O-alkylaryl, â€”O-alkylheteroaryl, â€”N(H)aryl, â€”N(aryl)2, â€”N(H)heteroaryl, â€”N(heteroaryl)2, â€”N(H)alkylaryl, â€”N(alkylaryl)2, â€”N(H)alkylheteroaryl, â€”N(alkylheteroaryl)2, â€”S-aryl, â€”S-heteroaryl, â€”S-alkylaryl, â€”S-alkylheteroaryl, â€”C(O)aryl, â€”C(O)heteroaryl, â€”C(O)alkylaryl, â€”C(O)alkyheteroaryl, â€”CO2aryl, â€”CO2heteroaryl, â€”CO2alkylaryl, â€”CO2alkylheteroaryl, â€”C(O)N(H)aryl, â€”C(O)N(aryl)2, â€”C(O)N(H)heteroaryl, â€”C(O)N(heteroaryl)2, â€”C(O)N(H)alkylaryl, â€”C(O)N(alkylaryl)2, â€”C(O)N(H)alkylheteroaryl, â€”C(O)N(alkylheteroaryl)2, â€”S(O)2-aryl, â€”S(O)2-heteroaryl, â€”S(O)2-alkylaryl, â€”S(O)2alkylheteroaryl, â€”S(O)2N(H)aryl, â€”S(O2)N(H)heteroaryl, â€”S(O2)N(H)alkylaryl, â€”SO)2N(H)alkylheteroaryl, â€”S(O)2N(aryl)2, â€”S(O)2N(H)(heteroaryl)2, â€”S(O)2N(alkylaryl)2, â€”S(O)2N(alkylheteroaryl)2, â€”N(H)C(O)N(H)aryl, â€”N(H)C(O)N(H)heteroaryl, â€”N(H)C(O)N(H)alkylaryl, â€”N(H)C(O)N(H)alkylheteroaryl, â€”N(H)C(O)N(aryl)2, â€”N(H)C(O)N(heteroaryl)2, â€”N(H)C(O)N(alkylaryl)2, or â€”N(H)C(O)N(alkylheteroaryl)2; R19 is â€”H, -alkyl, -cycloalkyl, -aryl, -heteroaryl, -alkylaryl, -alkylheteroaryl, or -alkylheterocycle; R20 is -alkyl-R18; m is 0 or 1; and X is O or S.