Patent ID: 6495566
Filing Date: 2002-12-17
Classification: A61P,C07D,Y02P

Abstract:
A method for the treatment or prophylaxis of pain in a subject in need thereof comprising administering an effective amount of a compound of formula (I): or a salt or a non-toxic metabolically labile ester thereof, whereinY is a carbon atom; Z is the group CH which is linked to the group Y via a double bond and X is CH, or Z is methylene or NR11 and X is a carbon atom linked to the group Y via a double bond; A is C1-2alkylene chain optionally substituted by one or two groups selected from the group consisting of &boxH;O and C1-6alkyl optionally substituted by hydroxy, amino, C1-4alkyl amino or C1-4dialkyl amino; R is a halogen atom or C1-4alkyl group; R1 is a hydrogen, a halogen atom or C1-4alkyl group; R2 is selected from the group consisting of phenyl optionally substituted with up to 3 groups selected from the group consisting of halogen, hydrogen, or (CH2)nR3 wherein R3 is COR4, NR6R5, NHCOR7, NHCONR9R8 or NHSO2R10; a 5 membered heteroaryl group containing 1 to 3 heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen; and a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms R4 is an amino, a hydroxyl or C1-4 alkoxy group; R5 and R6 are each independently hydrogen or C1-4alkyl group or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 5-7 membered heterocyclic group optionally containing an additional heroatom selected from oxygen, sulphur and nitrogen R7 is a hydrogen atom, C1-4alkyl, C1-4alkoxy, or phenyl; R8 is hydrogen or C1-4alkyl group; R9 is hydrogen, C1-4alkyl optionally substituted by one or more of hydroxy, carboxyl or amino groups, or phenyl; R11 is hydrogen or C1-4alkyl group; R10 is hydrogen, C1-4alkyl or a nitrogen protecting group; and n is 0, 1 or 2.