Patent ID: 6207665
Filing Date: 2001-03-27
Classification: A61P,C07D

Abstract:
A compound of formula (Ia): ##STR16##wherein:R.sup.1a is a substituent selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, (hydroxy)aralkyl, haloalkylcarbonylaminoalkyl, alkoxyalkyl, monoalkylaminoalkyl, monoaralkylaminoalkyl, (alkoxycarbonylalkyl)ureidoalkyl, hydroxyalkylaminoalkyl, aryloxyalkylcarbonyloxyalkyl, alkoxycarbonyl, and alkoxycarbonylalkyl;or R.sup.1a is two substituents, wherein one substituent is an alkyl radical and the other substituent is selected from the group consisting of alkyl, (hydroxy)aralkyl, hydroxyalkyl, alkylthioalkyl, aralkoxyalkyl, (hydroxy)alkylthioalkyl, alkylcarbonylalkyl, dialkylaminoalkyl, cycloalkylaminoalkyl, morpholin-4-ylalkyl, and piperazin-4-ylalkyl;R.sup.2 is fluoro in the 4-position;R.sup.3 is phenyl optionally substituted by one to three substituents selected from the group consisting of halo, alkoxy, alkylcarbonylamino, and piperazin-4-ylalkyl (wherein the piperazinyl radical is optionally substituted by phenylcarbonyl where the phenyl radical is optionally substituted by haloalkyl);R.sup.4 is --O--;R.sup.5 is methylene; andR.sup.6 is --C(O)--;as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.