Patent ID: 6099563
Filing Date: 2000-08-08
Classification: A61L,Y10S

Abstract:
A medical device having a bio-active coating on at least a portion of a surface thereof, said bio-active coating comprising a first substantially water-insoluble coating layer formed from an aqueous dispersion or emulsion of an organic acid functional group-containing polymer and a polyfunctional cross-linking agent, wherein a portion of said polyfunctional cross-linking agent is covalently bonded to said organic acid groups on said polymer and further wherein an excess of said polyfunctional cross-linking agent is not covalently bonded to said organic acid groups on said polymer, and a second coating of an aqueous solution or dispersion containing an organic acid functional group-containing bio-active agent, said first coating covalently bonded to said second coating through said excess cross-linking agent and said organic acid functional groups on said bio-active agent.