Patent ID: 8859538
Filing Date: 2014-10-14
Classification: A61P,C07D

Abstract:
1. A method of activation of a cannabinoid receptor in a mammalian subject, in need thereof, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor is associated with an inflammatory disease, disorder or condition associated with elevated levels of one or more cytokines selected from the group consisting of TNFα, IL-1 β, IL-6, IL-8 and GM-CSF, and wherein formula I is as follows: Y is selected from the group consisting of NR Z is selected from the group consisting of a bond, —(CH R R wherein the alkyl, alkenyl and aryl of R b are each optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 4 alkoxy, aryl, 5-, 6-, and 7-membered heterocyclyl, halo, —OH, —NH 2 , —CN and —NO 2 ; R R R R R R R R R R R R R X m is an integer selected from 1 and 2; each instance of p is independently an integer from 1 to 6; and each instance of q is independently zero or an integer from 1 to 4; and provided that when R