Patent ID: 6248712
Filing Date: 2001-06-19
Classification: A61K,A61P,C07K,C12N,C12Q,C12Y,G01N

Abstract:
A method for inhibiting localized extracellular proteolytic activity in a mammal, comprising inhibiting the activation of plasminogen to plasmin by preventing the binding of a plasminogen converting receptor binding form of urokinase-type plasminogen activator (u-or its proenzyme (pro-u-to a urokinase-type plasminogen activator receptor (u-PAR) in the mammal and thereby preventing said form of u-PA or its proenzyme (pro-u-from converting plasminogen into plasmin, wherein the prevention of the binding of said form of u-PA or its proenzyme (pro-u-to a u-is performed by administration, to the mammal, of a substance specifically binding to said form of u-PA or its proenzyme (pro-u-or to a u-PAR, the substance being administered in an amount effective to reduce the binding of said form of u-PA or its proenzyme (pro-u-to the receptor, thereby inhibiting activation of plasminogen to plasmin and hence inhibiting said proteolytic activity.