Patent ID: 9169314
Filing Date: 2015-10-27
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated fusion protein which comprises an isolated polypeptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:36 fused to a heterologous polypeptide, said isolated polypeptide having a kunitz-type-protease-inhibitor (KPI) domain, wherein the KPI domain of the polypeptide comprises a Phe at a position corresponding to position 40 of SEQ ID NO:36, a Gly at a position corresponding to position 44 of SEQ ID NO: 36; a Cys at a position corresponding to position 45 of SEQ ID NO:36, a Phe at a position corresponding to position 52 of SEQ ID NO:36, and a Cys at a position corresponding to position 58 of SEQ ID NO:36.