Patent ID: 8586737
Filing Date: 2013-11-19
Classification: A61P,C07D

Abstract:
1. A process for preparing a quaternary ammonium salt of formula (4): wherein X is halogen atom, C Y is a substituent of the following formula (3a) or (3b): wherein R Z is ═N—R comprising reacting a compound of formula (1): wherein Z is as defined above with 1 to 2 mole of a compound of formula (2): wherein X is independently selected from the above-defined ones, and Y is as defined above, per one mole of the compound of formula (1) in the presence of 1 to 5 mole of a phosphate per one mole of the compound of formula (1) and 0.01 to 0.1 part by weight of water per one part by weight of the phosphate.