Patent ID: 6268142
Filing Date: 2001-07-31
Classification: C12Q,G01N,Y10T

Abstract:
A method for determinjg whether a subject has or is predisposed to developing a disease or condition that is associated with an IL-1 inflammatory haplotype, comprising detecting an allelic pattern of at least two alleles selected from the group consisting of: allele 1 of +4845 IL-1A, allele 4 of 222/223 IL-1A allele, allele 4 of gz5/gz6 IL-1A, allele 1 of -889 IL-1A, allele 2 of -511 IL-.beta.B, allele 3 of gaat.p33330, allele 3 of Y31, allele 2 of +2018 IL-1RN, allele 2 of 1731 IL-1RN allele, allele 2 of 1812 IL-1RN, allele 2 of 1868 IL-1RN, allele 2 of 1887 IL-1RN, allele 2 of 8006 IL-1RN, allele 2 of 8061 IL-1RN and allele 2 of 9589 IL-1RN, allele 2 of +4845 IL-1A, allele 3 of 222/223 IL-1A allele, allele 3 of gz5 IL-1A, allele 2 of -889 IL-1A, allele 1 of -511 IL-1B, allele 4 of gaat.p33330, allele 6 of Y31 and allele 1 of +2018 IL-1RN, wherein the presence of the allelic pattern indicates that the subject is predisposed to the development or has tihe disease or condition.