Patent ID: 6281237
Filing Date: 2001-08-28
Classification: C07D,G01N

Abstract:
A compound of the formula: ##STR20##or a pharmaceutically acceptable non-toxic salt thereof wherein:A represents N;G represents halogen, trifluoromethyl, trifluoromethoxy, cyano, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, hydroxy, hydroxy(C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, --SH, (C.sub.1 -C.sub.6)alkylthio-, thio (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkyl thio(C.sub.1 -C.sub.6)alkyl;R.sub.1 represents hydrogen, (C.sub.1 -C.sub.6)alkyl, or hydroxy(C.sub.1 -C.sub.6)alkyl;R.sub.2 represents hydrogen or (C.sub.1 -C.sub.6)alkyl; andR.sub.3, and R.sub.4 are the same or different and represent hydrogen, halogen, trifluoromethyl, trifluoromethoxy, cyano, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, hydroxy, hydroxy(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl, --SH, (C.sub.1 -C.sub.6)alkylthio, thio(C.sub.1 -C.sub.6) alkyl or (C.sub.1 -C.sub.6)alkyl thio(C.sub.1 -C.sub.6)alkyl;R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and represent hydrogen, halogen, trifluoromethyl, trifluoromethoxy, cyano, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkoxy, hydroxy(C.sub.1 -C.sub.6)alkoxy, hydroxy, hydroxy(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6) alkoxy(C.sub.1 -C.sub.6)alkyl, --SH, (C.sub.1 -C.sub.6)alkylthio, thio(C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkyl thio(C.sub.1 -C.sub.6)alkyl.