Patent ID: 6057298
Filing Date: 2000-05-02
Classification: A01K,A61K,C07K,C12N

Abstract:
A method of treating skin cancer in a mammal comprising administering a K-1 keratin expression vector at or directly around the site of a skin cancer cell, wherein said vector comprises in operable association:a nucleic acid sequence encoding a functional p53 protein;a 5' flanking region from a mammalian gene including necessary sequences for expression of said nucleic acid sequence;a 3' flanking region from a mammalian K1 keratin gene which regulates expression predominantly in epidermal tissue; anda linker connecting said 5' flanking region to said nucleic acid sequence, said linker having a position in which said nucleic acid sequence is inserted,wherein expression of said p53 protein by said skin cancer cell results in inhibition of the cell's proliferation.