Patent ID: 8829210
Filing Date: 2014-09-09
Classification: A61K,A61P,C07D

Abstract:
1. A process of preparation of docetaxel trihydrate (I)— comprising the steps of— a. selectively chloroacylating 7 and 10 hydroxy functions of 10-Deacetyl baccatin III (or 10 DAB III) in halohydrocarbon solvent and pyridine to get (A); b. condensing (A) with benzyl protected side chain (B) in presence of a condensing agent and a moderator in an organic hydrocarbon solvent; c. selective debenzylation of side chain using a reducing agent in an organic solvent to get (D); d. selectively deprotecting 7,10-di-O-chloroacyl group from (D) using a base to get docetaxel (E)— e. treating docetaxel (E) or purified docetaxel (F) in the presence of organic solvents selective from—2-alkoxy ethanol or dimethylsulphoxide and with water.