Patent ID: 6310081
Filing Date: 2001-10-30
Classification: C07D

Abstract:
A compound of formula I having the structure ##STR20##whereinA is ##STR21##Q is ##STR22##B is nitrogen;D is oxygen, sulfur, or nitrogen;E is carbon or nitrogen;X is carbon, nitrogen, oxygen, or sulfur;Y is a bond, methylene, C(O), or CH(OH);Z is CH.dbd.CH, nitrogen, oxygen, or sulfur;the dashed line of Q represents an optional double bond;R.sup.1 is alkyl of 1 to 12 carbons, aryl of 6-10 carbon atoms, aralkyl of 7-15 carbon atoms, halogen, trifluoromethyl, alkoxy of 1-6 carbon atoms, Het-alkyl wherein the alkyl moiety contains 1-6 carbon atoms, or aryl of 6-10 carbon atoms mono-, di-, or tri-substituted with trifluoromethyl, alkyl of 1-6 carbon atoms or, alkoxy of 1-6 carbon atoms;Het is ##STR23##R.sup.7 is alkylene of 1 to 3 carbon atoms,G is oxygen, sulfur or nitrogen;R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, or trifluoromethyl;R.sup.3 and R.sup.4 are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, halogen, trifluoromethyl, alkoxy of 1-6 carbon atoms, aryl of 6-10 carbon atoms mono-, di-, or tri-substituted with trifluoromethyl, alkyl of 1-6 carbon atoms or, alkoxy of 1-6 carbon atoms, nitro, alkylsulfamide; arylsulfamide, cycloalkyl of 3-8 carbon atoms or a heterocyclic ring containing 5 to 7 ring atoms having 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur;R.sup.5 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or aralkyl of 7-15 carbon atoms;R.sup.6 is hydrogen, --OR.sup.5, or --OCOR.sup.5 ;with the proviso that when R.sup.1 is halogen,Y is a bond,or a pharmaceutically acceptable salt thereof.