Patent ID: 6403613
Filing Date: 2002-06-11
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound selected from the group consisting of(a) a substantially chirally pure (R)-enantiomer, a substantially chirally pure (S)-enantiomer, or a mixture of the (R)- and (S)-enantiomers of a 2-(2,6-dioxopiperidin-3-yl)-isoindoline of the formula: in which a first of R1 and R2 is halo, alkyl of from 1 to 4 carbon atoms, alkoxy of from 1 to 4 carbon atoms, dialkylamino in which each alkyl is of from 1 to 4 carbon atoms, cyano, or carbamoyl, the second of R1 and R2, independently of the first, is hydrogen, halo, alkyl of from 1 to 4 carbon atoms, alkoxy of from 1 to 4 carbon atoms, alkylamino in which alkyl is of from 1 to 4 carbon atoms, dialkylamino in which each alkyl is of from 1 to 4 carbon atoms, cyano, or carbamoyl, and R3 is hydrogen, alkyl of from 1 to 4 carbon atoms, or benzyl, and (b) an acid addition salt of said 2-(2,6-dioxopiperidin-3-yl)-isoindolines which contain a nitrogen atom capable of being protonated.