Patent ID: 6627396
Filing Date: 2003-09-30
Classification: C12Q,G01N,Y10S,Y10T

Abstract:
A sensor for detection of tetrameric multivalent neuraminidase within a sample, where a positive detection indicates presence of a target virus containing tetrameric multivalent neuraminidase within said sample, said sensor comprising:a surface; recognition molecules each bound through a spacer group of a defined length to an individual trifunctional linker moiety situated movably at said surface through an alkyl chain, each individual trifunctional linker moiety further including a single fluorescence label thereon for generating a fluorescent signal upon a predetermined binding event, said recognition molecules having a binding affinity with tetrameric multivalent neuraminidase; and, a means of measuring for change in fluorescent properties in response to binding between multiple recognition molecules and said tetrameric multivalent neuraminidase where a change in fluorescence indicates presence of said target virus.