Patent ID: 6093707
Filing Date: 2000-07-25
Classification: A61K,A61P,C07J

Abstract:
A hormonal or antihormonal steroid compound of structure I, ##STR10## wherein R.sup.1 is ##STR11## where q is 0 or 1, Y is --(CH.sub.2).sub.m -- where m is an integer of 0 to 5, where the CH.sub.2 groups may be optionally substituted; orR.sup.1 is N-imidazolyl-, N-pyrrolyl-2'-furyl, 3'-furyl-, 2'-thiophenyl, 3'-thiophenyl-, 2'-pyridyl, 3'-pyridyl, 4'-pyridyl-, 2'-thiazolyl-, 2'-N-methylimidazolyl- or 5'-pyrimidinyl-; andR.sup.12 is H or halo; orX is O or NOR.sup.5, where R.sup.5 is H or C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or C.sub.6-12 aryl, any of which may be optionally substituted; orX is (H, H), (H, OH), (H, OSi(C.sub.1-6 alkyl).sub.3), or (H, OCOR.sup.5), where R.sup.5 is C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.6-12 aryl, aralkyl, aralkenyl, aralkynyl, any of which may be optionally substituted; orR.sup.6 is H, C.sub.1-6 alkyl, or halogen;R.sup.7 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.2-6 alkynyl, C.sub.3-8 cycloalkyl, C.sub.6-12 aryl, aralkyl, aralkenyl, or aralkynyl any of which may be optionally substituted, and pharmaceutically acceptable salts thereof.