Patent ID: 6335444
Filing Date: 2002-01-01
Classification: C07B,C07C,C07D

Abstract:
An amino alcohol derivative of formula (2):R2â€”CH2â€”(C*)H(NHP1)â€”(C*)H(OH)â€”R1â€ƒâ€ƒ(2) wherein C* is an asymmetric carbon atom; P1 is an alkyl group having from 3 to 18 carbon atoms or an amino-protecting group selected from the group consisting of (i) a benzyloxycarbonyl group which may be substituted with a nitro group, a halogen atom, a lower alkoxyl group, a (lower alkoxyl)phenylazo group or a phenylazo group and (ii) an alkoxycarbonyl group having a straight, branched or cyclic alkyl group which may be substituted with a fluorenyl group or a methylsulfonyl group; R1 is an alkyl group, a cycloalkyl group or an aryl group; and R2 is wherein R3 and R4 are the same or different and each is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a hydroxyl-lower-alkyl group, a lower alkoxyalkyl group, an amino-lower-alkyl group, a cycloalkyl group, a hydroxycycloalkyl group, an aralkyl group or a piperazino group which may be substituted with a lower alkyl group; and when R3 and R4 each is a hydrogen atom; R7 is a lower alkylene group which may be discontinued by an oxygen atom; R8 and R9 are the same or different and each is a hydrogen atom, a lower alkyl group or a hydroxyl-lower-alkyl group, or R8 and R9 are together with a nitrogen atom to which each is bound, a piperidino group or a morpholino group, each of which may be substituted with a lower alkyl group; p is 2 or 3; and X is formula (VII) or (VIII): wherein R10 is a hydrogen atom, a lower alkyl group, an acyl group, a (lower alkoxyl)carbonyl group or a pyridyl group.