Patent ID: 7291339
Filing Date: 2007-11-06
Classification: A61K,A61P,C07C,C07K

Abstract:
1. A hybrid protein comprising two different coexpressed amino acid sequences forming a heterodimer, each comprising: (a) at least one amino acid sequence selected from the group consisting of a chain of a homomeric-receptor, a chain of a heteromeric receptor, a ligand other than a gonadotropin, a fragment of said chain of said homomeric receptor, said chain of said heteromeric receptor, or said ligand, wherein said ligand or fragment thereof retains ligand-receptor binding capability and said chain of said homomeric receptor or fragment thereof, and said chain of said heteromeric receptor or fragment thereof retain ligand-receptor binding capability either alone or in association with a homologous or heterologous chain of said receptor; and (b) a heterodimeric scaffold which is a subunit of a circulating non-immunoglobulin protein, or a fragment thereof which retains the ability of the subunit to form a heterodimer with other subunits thereof; wherein sequences (a) and (b) are joined either directly or through a peptide linker, and in which the sequences (b) in each of said two coexpressed sequences aggregate with each other to dimerize and form a heterodimer.