Patent ID: 6915227
Filing Date: 2005-07-05
Classification: G01N

Abstract:
1. A process for correcting a time axis of local chromatographic data to match reference chromatographic data while maintaining peak areas, comprising: obtaining reference calibration data from a reference chromatographic system; obtaining local calibration data from a local chromatographic system; generating local system correction functions based on an appropriate mathematical relationship using the reference calibration and the local calibration data; and applying the local system correction functions to local chromatographic data to generate corrected local chromatographic data, wherein the corrected local chromatographic data match with the reference calibration data on time axis and wherein peak areas in the local chromatographic data are maintained in the corrected local chromatographic data, wherein the local system correction functions include a smoothed x-axis correction function and a y-axis correction function generated using one or more mathematical curve fitting techniques, said y-axis correction function is a first derivative of the x-axis correction function.