Patent ID: 6492434
Filing Date: 2002-12-10
Classification: A61K,A61L,Y10S

Abstract:
A method for inhibiting the formation of surface skin ulceration characterized by either decubitus ulcers or diabetic ulcers in a patient which method comprises:identifying an unbroken, uninfected, unwounded skin surface area prone to decubitus or diabetic ulceration; applying to said unbroken, uninfected, unwounded skin surface area prone to said ulceration a sufficient amount of a cyanoacrylate adhesive so as to cover said area; and polymerizing the cyanoacrylate adhesive so as to form a flexible, waterproof, adhesive polymer coating which adheres to the area where the adhesive was applied, wherein the cyanoacrylate, in monomeric form, is represented by formula I: where R is selected from the group consisting of:alkyl of 2 to 10 carbon atoms, alkenyl of from 2 to 10 carbon atoms, cycloalkyl groups of from 5 to 8 carbon atoms, phenyl, 2-ethoxyethyl, 3-methoxybutyl, and a substituent of the formula: wherein each Râ€² is independently selected from the group consisting of:hydrogen and methyl, and Râ€³ is selected from the group consisting of:alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms, alkynyl of from 2 to 6 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms, aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl, phenyl, and phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.