Patent ID: 9102710
Filing Date: 2015-08-11
Classification: A61K,C07K

Abstract:
1. Cyclic monomeric peptides containing up to eight amino acids characterised in that they exert an agonist or antagonist action on the CXCR4 receptor and that they have the following general formula (I): wherein: the N- terminal group Nt of the peptide is selected between free amine and acetyl (Ac); the C terminal group Ct of the peptide is selected between free carboxylate, and primary amide (Nam); the N terminal sequence (Ns) optionally present has a formula selected between B-x-; and B-x-x; the C terminal sequence (Cs) optionally present is -x-B; wherein B represents an encoded basic amino acid residue selected from lysine (K) and arginine (R) and wherein x represents an encoded amino acid residue selected from glycine (G), alanine (A) and proline (P); wherein said sequences (Ns) and (Cs) may be present with mutual exclusion or both be absent; both amino acid residues Nc and Cc, are cysteine (C) and are both present; the bond tc that involves the amino acid residues Nc and Cc in the ring formation is—a disulphide bridge between cysteine side chains (css); the central sequence X or pharmacologically acceptable salts thereof.