Patent ID: 7338952
Filing Date: 2008-03-04
Classification: C07C,C07D

Abstract:
1. A method for treating or ameliorating a reactive oxygen species mediated inflammatory disorder in a subject in need thereof wherein the reactive oxygen species mediated inflammatory disorder is a phosphorylation mediated disorder, a polymorphonuclear leukocyte mediated disorder, a macrophage mediated disorder, a lipopolysaccharide mediated disorder, a tumor necrosis factor-α mediated disorder, a cytokine IFN-γ mediated disorder, an interleukin-2 mediated disorder, inflammatory arthritis, potassium peroxochromate arthritis, rheumatoid arthritis, osteoarthritis or Alzheimer's disease, said method comprising administering to the subject a therapeutically effective amount of the compound of Formula (I): wherein: A is (C B is aryldiyl or heteroaryldiyl; E is aryldiyl or heteroaryldiyl; R R R R R (R (R (R (R (R R R q is 1, 2, 3, 4 or 5; and, s is 1 or 2; and enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.