Patent ID: 6455548
Filing Date: 2002-09-24
Classification: A61K,C07D

Abstract:
A compound of the formula I: wherein:R1 is selected from the group consisting of:(1) â€”CH2-phenyl, and (2) â€”CH2-(2,4-dicholorophenyl wherein R5 is C1-8alkyl, which is substituted, where the substituents are independently selected from:(a) hydroxy, (b) C1-3alkoxy, (c) â€”Oâ€”C1-3alkylâ€”Oâ€”C1-3alkyl, (d) â€”Oâ€”C1-3alkyl-hydroxy, (e) â€”Oâ€”C1-3alkyl-cyclopropyl, (f) â€”Oâ€”C1-3alkyl-cyclobutyl, (g) â€”Oâ€”C3-4alkenyl (h) â€”OC(C1-6alkyl), (i) â€”NH2, (j) â€”NHCO(C1-6alkyl), (k) â€”NHSO2(C1-6alkyl), (l) cyclobutyl, (m) cyclopentyl, (n) cyclohexyl, (o) cycloheptyl, (p) tetrahydropranyl, (q) piperidinyl, and (r) Nâ€”(C1-6alkyl)piperidinyl; and wherein R11 is selected from: (1) â€”hydrogen, (2) â€”OH, (3) â€”C1-6alkyl, and (4) â€”halogen; R3 is 3â€”thienyl; R4c, R4d, and R4f are independently selected from the group consisting of: (1) hydrogen, and (2) C1-6 alkyl; and pharmaceutically acceptable salts thereof and individual diastereomers thereof.