Patent ID: 6627755
Filing Date: 2003-09-30
Classification: C07D

Abstract:
A compound of the formula whereinB is phenyl, pyridyl or pyrimidyl; X is N or CH; R2 is halo, cyano, (C1-C6) alkyl optionally substituted with from one to three fluorine atoms, nitro, amino, (C1-C6)alkylthio, (C1-C6)alkoxy optionally substituted with from one to three fluorine atoms, hydroxy, Hâ€”C(&boxH;O), (C1-C6)alkyl-Oâ€”C(&boxH;O)â€” or NH2-C(&boxH;O)â€”; R3 and R4 are selected, independently, from hydrogen, (C1-C6)alkyl optionally substituted with from one to three fluorine atoms, halo, cyano, hydroxy (C1-C6)alkoxy optionally substituted with from one to three fluorine atoms, â€”C(&boxH;O)H, â€”CH2OR5 and â€”CH2NR6R7; R5 is hydrogen, (C1-C6)alkyl or â€”C(&boxH;O)(C1-C6)alkyl; and R6 and R7 are selected, independently, from hydrogen, (C1-C6)alkyl and â€”C(&boxH;O)(C1-C6)alkyl; or R6 and R7, taken together with the nitrogen to which they are attached, form a four to seven membered saturated or unsaturated ring wherein one of the carbon atoms of such ring may optionally be replaced by oxygen or nitrogen; and Y-Z is â€”CH2NHâ€”, and R1 is fluoro; or a pharmaceutically acceptable salt of such compound.