Patent ID: 6468537
Filing Date: 2002-10-22
Classification: A61K,G01N,Y10S

Abstract:
A method of treating an animal having systemic lupus erythematosus (SLE) and a SLE-associated manifestation of nephritis, autoantibodies, and inflammation associated with autoantibodies, said method comprising administering to said animal an isolated peptide comprising a portion of a nucleosome histone protein wherein said peptide consists of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-5, 7, 9-10, 14, 18-19, and 22-26, and further wherein said isolated peptide is capable of specifically binding with a T cell receptor present on a cell, and further wherein said isolated peptide is capable of promoting immunological tolerance in an animal, thereby treating said SLE and said SLE-associated manifestation.