Patent ID: 6339092
Filing Date: 2002-01-15
Classification: A61P,C07D

Abstract:
A compound selected from those of the formula (I): wherein:R1 represents hydrogen, halogen, linear or branched (C1-C6)alkyl, or linear or branched (C1-C6)alkoxy, R2 represents hydroxy, linear or branched (C1-6)alkoxyl, or â€”NHOH, Ar1 represents phenylene or biphenylene, X represents oxygen, sulphur, NR, â€”Câ‰¡Câ€”, or a bond, R represents hydrogen or linear or branched (C1-C6)alkyl, n is 0 to 6 inclusive, Ar2 represents: phenyl substituted by a heteroaryl group, biphenyl substituted by a heteroaryl group, pyridinyl substituted by a heteroaryl group, or a heterocyclic group, its isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, it being understood that:â€œheteroaryl groupâ€  is understood to mean mono-cyclic aromatic or bi-cyclic aromatic group wherein at least one cycle is aromatic containing one, two or three identical or different hetero atoms selected from nitrogen, oxygen and sulphur, optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, linear or branched trihalo-(C1-C6)alkyl, linear or branched trihalo-(C1-C6)alkoxy, and hydroxy, â€œheterocyclic groupâ€  is understood to mean saturated or partially saturated, mono-or bi-cyclic non-aromatic group containing one, two or three identical or different hetero atoms selected from nitrogen, oxygen and sulphur, optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, linear or branched trihalo-(C1-C6)alkyl, linear or branched trihalo-(C1-C6)alkoxy, and hydroxy.