Patent ID: 9115238
Filing Date: 2015-08-25
Classification: C08F,C12N

Abstract:
1. A microcarrier for cell culture, comprising: (A) a polymeric microcarrier base formed from copolymerization of a mixture of monomers comprising: (B) a polypeptide conjugated to the microcarrier base, wherein the microcarrier base, prior to conjugation of the polypeptide, has an equilibrium water content (EWC) of greater than 75% in distilled, deionized water at room temperature, wherein EWC is determined by according to the following formula: EWC(%)=[(Wgel−Wdry)]*100, where Wgel is the weight of the microcarrier base, inclusive of water, after swelling in the deionized water and Wdry is the dry weight of the microcarrier base, and wherein the microcarrier base, prior to conjugation of the polypeptide, has pendant carboxylic acid groups of 2 milliequivalents or greater per gram of the microcarrier base.