Patent ID: 6716574
Filing Date: 2004-04-06
Classification: A61K,C07K,Y02A

Abstract:
A method for diagnosing the early stages of Lyme borreliosis, the method comprising contacting immunoglobulins or T-cells obtained from the subject with at least one immunological agent comprising a polypeptide fragment which has a length of at the most 60 amino acid residues and which contains carboxyterminally a peptide with the general formula I:A5-A4-A3-A2-A1 (SEQ ID NO: 41) whereA1 designates a residue of proline; A2 designates a residue of lysine; A3 designates a residue of lysine; A4 designates a residue of proline; and A5 designates residues of any amino acid, and subsequently detecting the degree, if any, of immunological reactivity between the immunoglobulins and the immunological agent or between the T-cells and the immunological agent, a immunological reaction being indicative of sensitization with OspC polypeptide from Borrelia burgdorferi sensu lato.