Patent ID: 6844175
Filing Date: 2005-01-18
Classification: A01K,A61K,A61P,C12N

Abstract:
1. A method for inhibiting a binding event between a selectin and a selectin ligand, said method comprising: contacting a cell that produces said selectin ligand with an agent that inhibits the sulfation activity of a glycosyl sulfotransferase-3 (GST-3) polypeptide, wherein the GST-3 polypeptide catalyzes the transfer of a sulfate group from a donor compound to a selectin ligand precursor, wherein the GST-3 polypeptide is encoded by a nucleic acid comprising a sequence that is at least 75% identical to the sequence set forth in SEQ ID NO:2, and wherein inhibition of said sulfation activity inhibits a binding event between the selectin and the selectin ligand.