Patent ID: 6994974
Filing Date: 2006-02-07
Classification: A01K,A61K,C07K,C12N,C12Y,G01N

Abstract:
1. A method for determining whether an agent inhibits binding of human ERAB polypeptide (SEQ. ID. NO: 2), or a fragment thereof, to amyloid-beta peptide which comprises: (a) incubating human ERAB polypeptide (SEQ. ID. NO: 2), or a fragment thereof, the agent and amyloid-beta peptide under suitable binding conditions; (b) determining the amount of amyloid-beta peptide bound to the polypeptide or fragment from the incubate of (a); and (c) comparing the amount of bound amyloid-beta peptide determined in step (b) to an amount of amyloid-beta peptide bound to the polypeptide or fragment determined in the absence of the agent, wherein when the amount of amyloid-beta polypeptide bound to the polypeptide or fragment thereof is decreased in the presence of said agent, the agent inhibits binding of human ERAB polypeptide (SEQ. ID. NO: 2), or the fragment thereof.