Patent ID: 6413947
Filing Date: 2002-07-02
Classification: C07C,C07D,C07F

Abstract:
A compound of the formula: whereinR1 is phenyl, furyl, thiophenyl, pyridyl, cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl or tetrahydropyranyl, each of which may be substituted, W is a divalent group of the formula: â€ƒwherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur atom or oxygen atom, Z is a chemical bond or a divalent group, R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: â€ƒwherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5 and R6 are independently an optionally substituted hydrocarbon group or an optionally substituted amino group, or R5 and R6 may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a pharmaceutically acceptable salt thereof.