Patent ID: 6521601
Filing Date: 2003-02-18
Classification: A61K,C07H,C12N

Abstract:
A method of inhibiting replication of a virus in an infected cell in vivo, comprisingselecting a DNA fragment having (i) a first region having 6-30 bases whose sequence corresponds to a sequence of DNA recognized by a viral-specific transcription factor, (ii) a second region having a sequence of nucleotides complementary to said first region, when said first and second regions are positioned in an anti-parallel configuration, and (iii) joining said first and said second regions in a 5â€² to 3â€² direction, a tetranucleotide sequence X1X2X3X4, where X1 is U or T, and X2 is U, T, G, A or C, and X3 is C, and X4 is G (SEQ ID NO: 14); or X1 is G, and X2 is U, T, G, A or C, and X3 is G or A, and X4 is A (SEQ ID NO: 15); or X1 is C, and X2 is U or T, and X3 is U or T, and X4 is G (SEQ ID NO: 16), and introducing the fragment into the cell in an amount sufficient to inhibit replication of the virus in the cell.