Patent ID: 8258314
Filing Date: 2012-09-04
Classification: C07D

Abstract:
1. Process for the preparation of substituted heteroaromatics of the general formula (I) where X is oxygen, sulphur or NR R R A) of a halogenated heteroaromatic of the general formula (II) where X has the meaning given for formula (I) and R R with a Grignard reagent of the general formula (III) where R Hal is bromine, iodine or chlorine or B) reaction of the halogenated heteroaromatics of the formula (II) with magnesium firstly to give a Grignard compound of the general formula (IIIa) where Hal is bromine, iodine or chlorine and X and R and further reaction with a halogenated compound of the general formula (IV) where R Hal is bromine, iodine or chlorine, where the reactions A) or B) are in each case carried out in the presence of an Ni or Pd catalyst, characterized in that the process is carried out in the presence of cyclopentyl methyl ether as solvent and optionally one or more further solvents.