Patent ID: 7589106
Filing Date: 2009-09-15
Classification: A61K,A61P

Abstract:
1. A pharmaceutically acceptable formulation of the compound of formula I or a pharmaceutically acceptable salt thereof, which is solubilized in an aqueous solution, said formulation comprising (a) argatroban of formula I or a pharmaceutically acceptable salt thereof (b) methionine, pharmaceutically acceptable salts thereof, and mixtures thereof; (c) a member selected from the group consisting of one or more non-amino acid pH adjusting organic acids, organic bases, inorganic acids or inorganic bases, or salts thereof and mixtures thereof; and (d) a member selected from the group consisting of lactobionic acid and pharmaceutically acceptable salts thereof, which formulation is substantially free of ethanol and substantially free of a sugar alcohol and has a pH in excess of 8.5.