Patent ID: 7635696
Filing Date: 2009-12-22
Classification: A61P,C07D

Abstract:
1. A compound according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or an N-oxide thereof, wherein: X is O; V is O or NR R R q is an integer equal to zero; 1 or 2; (CH (CH Pir is a bivalent radical according to any one of Formula (IIa), (IIb) or (IIc), each radical optionally substituted with p radicals R each R p is an integer equal to zero; 1 or 2; Ar is phenyl or naphthyl; each radical optionally substituted with one or more halo, cyano, oxo, hydroxy, alkyl, formyl, alkyloxy or amino radicals; heteroaryl represents a monocyclic heterocyclic radical selected from the group of azetidinyl; pyrrolidinyl; dioxolyl; imidazolidinyl; pyrrazolidinyl; piperidinyl; homopiperidinyl; dioxyl; morpholinyl; dithianyl; thiomorpholinyl; piperazinyl; imidazolidinyl; tetrahydrofuranyl; 2H-pyrrolyl; pyrrolinyl; imidazolinyl; pyrrazolinyl; pyrrolyl; imidazolyl; pyrazolyl; triazolyl; furanyl; thienyl; oxazolyl; isoxazolyl; thiazolyl; thiadiazolyl; isothiazolyl; pyridinyl; pyrimidinyl; pyrazinyl; pyridazinyl and triazinyl; each heterocyclic radical optionally substituted with one or more radicals selected from the group of alkyl, phenyl, phenyl substituted with alkyl, benzyl, halo, cyano, oxo, hydroxy, formyl, alkyloxy, alkylcarbonyl, tetrahydrofurylcarbonyl and amino; and alkyl represents a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, each hydrocarbon radical optionally substituted with one or more halo, cyano, oxo, hydroxy, formyl or amino radicals.