Patent ID: 6696274
Filing Date: 2004-02-24
Classification: A61K,C07K

Abstract:
A polypeptide comprising an amino acid sequence of the formula Y1-Y2-X3-Y4-X5-Y6-X7-Y8 whereY1 is a positively charged amino acid selected from the group consisting of Arg and Lys Y2 is Val, Leu, Ile or Met X3 is a natural alpha-amino acid Y4 is a negatively charged amino acid selected from the group consisting of Glu and Asp X5 is natural alpha-amino acid Y6 is a negatively charged amino acid selected from the group consisting of Glu and Asp X7 is natural alpha-amino acid Y8 is Thr or Ser wherein said polypeptide crosses the blood brain barrier or the gastrointestinal barrier.