Patent ID: 8088413
Filing Date: 2012-01-03
Classification: A61B,A61K,A61N,A61P

Abstract:
1. A process for increasing the efficacy of cancerous disease inhibiting therapeutic agents delivered to a tumor in need thereof comprising the steps of: exposing a predetermined volume of said tumor to hypothermic treatment resulting in formation of one or more regions selected from a hard ice region, a slush region, and a supra-zero hypothermia region within said tumor; inducing at least one cellular or molecular event associated with a thermal stress response resulting in the expression of one or more cold stress proteins which promote one or more pro-apoptotic mediators in said tumor that works synergistically with a sustained release microencapsulated cancerous disease inhibiting therapeutic agent; and delivering said sustained-release microencapsulated cancerous disease inhibiting therapeutic agent to said tumor when said cold stress proteins are expressed, thereby sensitizing said tumor to the effects of said therapeutic agent by promoting programmed cell death; whereby the increased efficacy of cancerous disease inhibition of said therapeutic agent within said treatment region results from the interaction of said mediators and the available sustained released agent.