Patent ID: 8759398
Filing Date: 2014-06-24
Classification: A23V,A61K

Abstract:
1. A composition for inhibiting absorption of phosphorus-containing anions from the gastrointestinal tract of a subject consisting of: a source of ionized calcium, a stool softener, and a non-gelatin capsule, wherein: a) the source of ionized calcium is a calcium succinate composition, b) the quantity of the calcium succinate composition provides ionized calcium in a quantity sufficient to bind with said phosphorus-containing anions in the gastrointestinal tract of the subject, c) the quantity of said stool softener is sufficient to reduce the incidence of constipation but not sufficient to increase the incidence of diarrhea, d) said stool softener is selected from the group consisting of docusate and lactulose, e) said stool softener does not interfere with the binding of said phosphorus-containing anions by said ionized calcium, f) said stool softener does not interfere with the manufacture of said composition, g) dissolution of the composition in water at 37° C. that is stirred at 50 RPM under the dissolution conditions described in the U.S. Pharmacopeia for Apparatus II releases at least about 80% of the calcium in the composition as ionized calcium in 30 minutes.