Patent ID: 6734302
Filing Date: 2004-05-11
Classification: A61P,C07D

Abstract:
At least one compound selected from a compound of formula I or pharmaceutically acceptable salts or esters thereof, whereinR is â€”C&boxH;OR1, wherein R1 is selected from C1-C4 alkyl, â€”C&boxH;CHCOOH, â€”NHCH2CH2R2, â€”N(CH2CH2OH)CH2CH2OH, â€”N(CH3)CH2CH2NCH3, â€”N(CH3)CH2CH2N(CH3)CH3, saturated 4-, 5- and 6-membered rings, and saturated and unsaturated 5- and 6-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O and being optionally substituted with a group selected from lower alkyl, â€”C&boxH;Oâ€”R5, â€”OH, lower alkyl substituted with hydroxy, lower alkyl substituted with â€”NH2, N-lower alkyl, â€”SO2CH3, &boxH;O, â€”CH2C&boxH;OCH3, and 5- and 6-membered saturated rings containing at least one hetero atom selected from S, N and O, wherein R5 is selected from H, lower alkyl, â€”NH2, â€”N-lower alkyl, lower alkyl substituted with hydroxy, and lower alkyl substituted with NH2, wherein R2 is selected from â€”N(CH3)CH3, â€”NHCH2CH2NH2, â€”NH2, morpholinyl and piperazinyl, X1, X2 and X3 are independently selected from â€”OH, C1-C2 alkyl, C1-C5 alkoxy, â€”Cl, â€”Br, â€”F, â€”CH2OCH3, and â€”CH2OCH2CH3, or one of X1, X2 or X3 is H and the other two are independently selected from hydroxy, lower alkyl, lower alkoxy, Cl, Br, F, â€”CF3, â€”CH2OCH3, â€”CH2OCH2CH3, â€”OCH2CH2R3, â€”OCH2CF3, and â€”OR4, or one of X1, X2 or X3 is H and the other two taken together with the two carbon atoms and the bonds between them from the benzene ring to which they are substituted form a 5- or 6-membered saturated ring that contains at least one hetero atom selected from S, N, and O, wherein R3 is selected from â€”F, â€”OCH3, â€”N(CH3)CH3, unsaturated 5- and 6-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O, wherein R4 is a 3- to 5-membered saturated ring and Y1 and Y2 are each independently selected from â€”Cl, â€”Br, â€”NO2, â€”Câ‰¡N, and â€”Câ‰¡CH.