Patent ID: 7785819
Filing Date: 2010-08-31
Classification: A61K,A61P,G01N

Abstract:
1. A method for selecting an antigen-specific treatment regimen for a patient with multiple sclerosis comprising: (a) providing an autoantigen array comprising at least two autoantigen elements associated with multiple sclerosis wherein each autoantigen element further comprises at least one immunologic epitope(s); (b) physically contacting the autoantigen array from step (a) with a patient sample comprising antibodies from a patient having multiple sclerosis; (c) identifying the autoantigens associated with multiple sclerosis within the array that bind to antibodies within the patient sample from step (b); (d) comparing the antibodies from the patient sample bound to the autoantigens in step (c) with (1) antibodies from a positive reference or control sample wherein the antibodies from the positive reference or control sample are known to be associated with multiple sclerosis; and, (2) antibodies from a negative reference or control sample wherein the antibodies from the negative reference or control sample are not associated with multiple sclerosis, thereby determining an antibody specificity profile specific for the patient; (e) selecting an antigen-specific treatment regimen based on the antibody specificity profile; and (f) administering the antigen-specific treatment regimen, wherein the antigen-specific regimen comprises administering one or more autoantigens identified in step (c).