Patent ID: 6010719
Filing Date: 2000-01-04
Classification: A61K,Y10S

Abstract:
Freeze-dried disintegrating tablets, said tablets containing at least a therapeutic agent, a matrix forming agent and a binding agent, in which the tablets contain more than 20% by weight of a matrix forming agent selected from the group consisting of maltodextrins having a DE value between 12 and 40, isomalt and mixtures thereof, the weight ratio between said matrix forming agent and the binding agent being comprised between 2:1 and 50:1, in which said matrix forming agent and the binding agent are present in the tablets in an amount for ensuring a strength of the tablets of at least 1.5N and a disintegration time of the tablets between 10 and 120 seconds, said strength being the maximal force recorded when penetrating at a speed of 0.1 mm/second a cone probe over a depth of 1 mm in a tablet.