Patent ID: 6066642
Filing Date: 2000-05-23
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula ##STR36## or a pharmaceutically acceptable salt thereof, wherein R.sub.2 is a C.sub.1 -C.sub.6 alkyl; R.sub.6 is phenyl which may be further substituted with C.sub.1 -C.sub.6 alkyl, halo, nitro, furyl, or thienyl; R.sub.3 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyloxycarbonyl, aryl C.sub.1 -C.sub.6 alkyloxycarbonyl, C.sub.1 -C.sub.6 alkylthiocarbonyl, C.sub.1 -C.sub.6 alkylaminocarbonyl, and C.sub.1 -C.sub.6 alkyloxy C.sub.1 -C.sub.6 alkylcarbonyl, or R.sub.3 together with R.sub.2 forms a ring having 2-4 methylene groups, and C.sub.1 -C.sub.6 alkenyloxycarbonyl; R.sub.4 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, aryl C.sub.2 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.6 alkyl silyl C.sub.1 -C.sub.6 alkyloxy, aryl, heterocyclic, aryl C.sub.1 -C.sub.6 alkyl, phenylacetylenyl which may be further substituted with nitro, C.sub.1 -C.sub.6 alkyl, hydroxy, halo, amino, carboxy, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 haloalkyl, or C.sub.1 -C.sub.6 alkylamino, and styryl whose phenyl ring may be further substituted with one or more substituents selected from the group consisting of halo, nitro, amino, hydroxy, C.sub.1 -C.sub.6 alkyl, cyano, C.sub.1 -C.sub.6 alkyloxy, C.sub.1 -C.sub.6 alkyloxycarbonyl, C.sub.1 -C.sub.6 alkylcarbonyl, hydroxy C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 haloalkyl, carboxy, aminocarbonyl, C.sub.1 -C.sub.6 alkylamino, amino C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 dialkylamino; and R.sub.5 is selected from the group consisting of C.sub.1 -C.sub.6 alkyloxycarbonyl, aryl C.sub.1 -C.sub.6 alkyloxycarbonyl, C.sub.1 -C.sub.6 alkyloxy C.sub.1 -C.sub.6 alkyloxycarbonyl, aryloxy C.sub.1 -C.sub.6 alkyloxycarbonyl, aryl C.sub.1 -C.sub.6 alkyloxy C.sub.1 -C.sub.6 alkyloxycarbonyl, silyl C.sub.1 -C.sub.6 alkyloxycarbonyl, C.sub.1 -C.sub.6 alkylthio, hydroxy, and C.sub.1 -C.sub.6 alkylamino, wherein the aryl moiety of said R.sub.5 may be further substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 halo alkyl, trifluoromethyl, halo, nitro, C.sub.1 -C.sub.6 amino alkyl, C.sub.1 -C.sub.6 aminoalkylamino, or C.sub.1 -C.sub.6 amino alkylamino carbonyl; wherein the aryl moiety of said R.sub.3, R.sub.4, R.sub.5, and R.sub.6 is independently phenyl or naphthyl.