Patent ID: 8778880
Filing Date: 2014-07-15
Classification: A61K,A61P,C07H,C07K,C08G,G01N

Abstract:
1. A human growth hormone (hGH) polypeptide comprising an amino acid sequence of SEQ ID NO: 2, wherein said hGH polypeptide comprises one or more polyethylene glycol moieties wherein the molecular weight of said polyethylene glycol is in a range of 10 k-40 k Dalton and wherein at least one polyethylene glycol moiety is attached to a para-acetyl-phenylalanine that is ribosomally incorporated into the hGH polypeptide at position 35 of SEQ ID NO: 2 and wherein the hGH polypeptide has a serum half-life at least three-fold greater than the serum half-life of an unmodified hGH polypeptide.