Patent ID: 8569319
Filing Date: 2013-10-29
Classification: A61P,C07D

Abstract:
1. A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer or tautomer thereof, wherein: A is wherein the “*” is connected to the R1-substituted phenyl ring and the “#” is connected to the amide carbonyl; W is —(CH X1 is halogen or C1-C6 alkyl; X2 is halogen or C1-C6 alkyl; each R1 is individually and independently halogen, H, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, branched C3-C6 alkoxy, or cyano; Z1 and Z2 are independently and individually CR2 or N; Z3 is CR3 or N; with the proviso that ring B is a monocyclic ring which is not a tetrazine; each R2 is individually and independently H, halogen, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, branched C3-C6 alkoxy, or cyano; R3 is —NHR4, H, —NR6(R7), C1-C8 alkyl, C2-C3 alkynyl, C3-C8 cycloalkyl, C1-C6-alkoxy-C1-C6-alkyl-, hydroxy-C1-C6-alkyl-, cyano, cyano-C1-C6-alkyl-, C1-C6-SO R4 is H, C1-C8 alkyl, C3-C8 cycloalkyl, —(CH R5 is C1-C7 alkyl, branched C3-C8 alkyl, C3-C8 cycloalkyl, —(CH each R6 and R7 is individually and independently H, C1-C6 alkyl, or branched C3-C8 alkyl; each R8 is individually and independently C1-C6 alkoxy, H, halogen, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, branched C3-C6 alkoxy, or cyano; each alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl is independently and optionally substituted with —(R25) each R25 is individually and independently C1-C6 alkyl, branched C3-C8 alkyl, halogen, —(CH each m is individually and independently 0, 1, 2, or 3; n is 0, 1, or 2; and each p is individually and independently 1, 2, or 3.