Patent ID: 7317000
Filing Date: 2008-01-08
Classification: A61K

Abstract:
1. An insulin derivative comprising a glucose-sensing group and a polyol moiety, wherein the glucose-sensing group is an aryl boronate group and is attached to the insulin moiety via a first linker, the first linker being selected from the group consisting of γ-glutamyl, α-glutamyl, β-aspartyl, α-aspartyl, β-alanine, 4-carboxy-phenylalanine, iminodiacetic acid, piperazine, and aniline, wherein the aryl boronate group is selected from the group consisting of A-Z and AA-AE below, wherein the substituent R in each of the groups designates the insulin moiety of the molecule including a polyol substituent and the first linker, wherein the polyol substituent is attached to the insulin moiety via the first linker, R′ designates a substituent selected among the options hydrogen, methyl, ethyl, propyl, isopropyl and benzyl and R″ designates a substituent selected among the options D-glucamine, L-glucamine, N-methyl-glucamine, galactamine, N-methyl-galactamine, mannamine, N-methyl-mannamine and tris(hydroxymethyl)aminomethane