Patent ID: 7635676
Filing Date: 2009-12-22
Classification: A01N,A61K,A61P,C07K

Abstract:
1. A method of protecting an organ or a tissue susceptible to ischemia reperfusion injury (IRI), comprising administering to a patient who is a recipient of an organ transplant a composition comprising an isolated annexin dimer at least 95% identical to a protein selected from the group consisting of SEQ ID NO: 6, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 19, SEQ ID NO: 23, SEQ ID NO: 3-linker-SEQ ID NO: 3, SEQ ID NO: 12-linker-SEQ ID NO: 12, and SEQ ID NO: 15-linker-SEQ ID NO: 15, SEQ ID NO: 3-linker-SEQ ID NO: 12, SEQ ID NO: 3-linker-SEQ ID NO: 15, SEQ ID NO: 12-linker-SEQ ID NO: 15, SEQ ID NO: 12-linker-SEQ ID NO: 3, SEQ ID NO: 15-linker-SEQ ID NO: 3 and SEQ ID NO: 15-linker-SEQ ID NO: 12, wherein the linker is at least one glycine-serine sequence, and whereby said administering protects said organ and tissue.