Patent ID: 6537996
Filing Date: 2003-03-25
Classification: A61P,C07D

Abstract:
A compound of formula 1: wherein R1 is lower alkyl, or OR5, where R5 is aryl, heterocyclyl, acyl, wherearyl and heterocyclyl are substituted with 1-3 R6 substituents selected from the group consisting of H, lower alkyl, lower alkenyl, OH, NO2, NH2, halo, trihalomethyl, â€”CN, SH, SO, SO2, SO3H, â€”OR, â€”COR, â€”COOR, â€”CONHR, â€”OCOR, and â€”NCOR, where R is lower alkyl; R2 is H or lower alkyl; R3 is aryl substituted with 1-3 R6 substituents; R4 is H, lower alkyl, aryl, aralkyl, â€”OH, â€”NH2, â€”NHR, or â€”OR, where R is lower alkyl or aryl-lower alkyl; and A is â€”CHâ€” or â€”Nâ€”; and pharmaceutically acceptable salts thereof.