Patent ID: 6586602
Filing Date: 2003-07-01
Classification: A61K,C07K

Abstract:
A compound of formula I: whereR1 is selected from the group consisting of alkyl, substituted alkyl, phenyl, substituted phenyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, heteroaryl and substituted heteroaryl; R2 and R3, together with the nitrogen atom bound to R2 and the carbon atom bound to R3, form a saturated heterocyclic group or a saturated substituted heterocyclic group with the proviso that when monosubstituted, the substituent on said saturated heterocyclic group is not carboxyl; R5 is selected from the group consisting of â€”(CH2)n-aryl and â€”(CH2)n-heteroaryl, where n is an integer equal to 1 to 4; Q is â€”C(X)NR7â€” wherein R7 is selected from the group consisting of hydrogen and alkyl, and X is selected from the group consisting of oxygen and sulfur; and pharmaceutically acceptable salts thereof with the proviso that when R1 is 2,4,6-trimethylphenyl, R2 and R3 together with the pendent nitrogen and carbon atoms form a pyrrolidinyl ring and Q is â€”C(O)NHâ€”, then R5 is not benzyl.