Patent ID: 6391890
Filing Date: 2002-05-21
Classification: C07D

Abstract:
A compound of formula I whereinR1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; X is ortho-phenylene, â€”Oâ€”, â€”Sâ€”, â€”C(R6R7)â€”, â€”CH2CH2â€”, â€”CH&boxH;CHâ€”CH2â€”, â€”CH2â€”CH&boxH;CHâ€”, â€”CH2â€”(C&boxH;O)â€”, â€”(C&boxH;O)â€”CH2â€”, â€”CH2CH2CH2â€”, â€”CH&boxH;CHâ€”, â€”N(R8)â€”(C&boxH;O)â€”, â€”(C&boxH;O)â€”N(R8)â€”, â€”Oâ€”CH2â€”, â€”CH2â€”Oâ€”, â€”OCH2Oâ€”, â€”Sâ€”CH2â€”, â€”CH2â€”Sâ€”, â€”(CH2)N(R8)â€”, â€”N(R8)(CH2)â€”, â€”N(CH3)SO2â€”, â€”SO2N(CH3, â€”, â€”CH(R10)CH2â€”, â€”CH2CH(R10)â€”, â€”(C&boxH;O)â€”, â€”N(R9)â€” or â€”(S&boxH;O)â€” wherein R6, R7, R8 and R9 independently are hydrogen or C1-6-alkyl, and wherein R10 is C1-6-alkyl or phenyl; Y is C; ---- is optionally a single bond or a double bond m is 1, 2, 3, 4, 5 or 6;and Z is wherein R3 is H or C1-6-alkyl; or a pharmaceutically acceptable salt thereof.