Patent ID: 7449460
Filing Date: 2008-11-11
Classification: A61P,C07D

Abstract:
1. A compound of Formula 1 wherein: Ar is a radical of the form:  wherein; A′ is a phenyl ring; wherein the phenyl ring is optionally mono- or di-substituted with a substituent selected from an alkyl of 1-6 carbon atoms, an alkenyl of 2-6 carbon atoms, an alkynyl of 2-6 carbon atoms, azido, a hydroxyalkyl of 1-6 carbon atoms, a halogen, a halomethyl, an alkoxymethyl of 2-7 carbon atoms, an alkanoyloxymethyl of 2-7 carbon atoms, an alkoxy of 1-6 carbon atoms, an alkylthio of 1-6 carbon atoms, hydroxy, a trifluoromethyl, a cyano, a nitro, a carboxy, an alkoxycarbonyl of 2-7 carbon atoms, an alkanoyl of 2-7 carbon atoms, a phenoxy, a phenyl, a thiophenoxy, a benzoyl, a benzyl, an amino, an alkylamino of 1-6 carbon atoms, a dialkylamino of 2 to 12 carbon atoms, a phenylamino, a benzylamino, an alkanoylamino of 1-6 carbon atoms, an alkenoylamino of 3-8 carbon atoms, an alkynoylamino of 3-8 carbon atoms, a carboxyalkyl of 2-7 carbon atoms, a carboalkoxyalkyl of 3-8 carbon atoms, an aminoalkyl of 1-5 carbon atoms, a N-alkylaminoalkyl of 2-9 carbon atoms, a N,N-dialkylaminoalkyl of 3-10 carbon atoms, an N-alkylaminoalkoxy of 3-9 carbon atoms, a N,N-dialkylaminoalkoxy of 4-10 carbon atoms, a mercapto, a methylmercapto, an alkanoyloxy of 1-6 carbon atoms, a alkenoyloxy of 3-8 carbon atoms, an alkynoyloxy of 3-8 carbon atoms, a carbamoyl, a N-alkylcarbamoyl of 2-7 carbon atoms, a N,N-dialkylcarbamoyl of 3-13 carbon atoms, and benzoylamino; T is substituted at a carbon of the phenyl ring with —O(CH L is an imidazole, pyridyl or a phenyl ring wherein the imidazole, pyridyl or phenyl ring is optionally substituted at a carbon or nitrogen with one, two, or three substituents independently selected from an alkyl of 1-6 carbon atoms, an alkenyl of 2-6 carbon atoms, an alkynyl of 2-6 carbon atoms, azido, a hydroxyalkyl of 1-6 carbon atoms, a halogen, a halomethyl, an alkoxymethyl of 2-7 carbon atoms, an alkanoyloxymethyl of 2-7 carbon atoms, an alkoxy of 1-6 carbon atoms, an alkylthio of 1-6 carbon atoms, a hydroxy, a trifluoromethyl, a cyano, a nitro, a carboxy, an alkoxycarbonyl of 2-7 carbon atoms, an alkanoyl of 2-7 carbon atoms, a phenoxy, a phenyl, a thiophenoxy, a benzoyl, a benzyl, an amino, an alkylamino of 1-6 carbon atoms, a dialkylamino of 2 to 12 carbon atoms, a phenylamino, a benzylamino, an alkanoylamino of 1-6 carbon atoms, an alkenoylamino of 3-8 carbon atoms, an alkynoylamino of 3-8 carbon atoms, a carboxyalkyl of 2-7 carbon atoms, a carboalkoxyalkyl of 3-8 carbon atoms, an aminoalkyl of 1-5 carbon atoms, an N-alkylaminoalkyl of 2-9 carbon atoms, an N,N-dialkylaminoalkyl of 3-10 carbon atoms, a N-alkylaminoalkoxy of 3-9 carbon atoms, a N,N-dialkylaminoalkoxy of 4-10 carbon atoms, a mercapto, a methylmercapto, an alkanoyloxy of 1-6 carbon atoms, an alkenoyloxy of 3-8 carbon atoms, an alkynoyloxy of 3-8 carbon atoms, a carbamoyl, an N-alkylcarbamoyl of 2-7 carbon atoms, a N,N-dialkylcarbamoyl of 3-13 carbon atoms, a benzoylamino, a 5- or 6-membered heteroaryl ring where the heteroaryl ring contains 1 to 3 heteroatoms selected from N, O, and S and where the heteroaryl ring may be optionally mono- or di-substituted with a substituent independently selected from a halogen, an oxo, a thiocarbonyl, an alkyl of 1-6 carbon atoms, an alkenyl of 2-6 carbon atoms, an alkynyl of 2-6 carbon atoms, azido, a hydroxyalkyl of 1-6 carbon atoms, a halomethyl, an alkoxymethyl of 2-7 carbon atoms, an alkanoyloxymethyl of 2-7 carbon atoms, an alkoxy of 1-6 carbon atoms, an alkylthio of 1-6 carbon atoms, a hydroxy, a trifluoromethyl, a cyano, a nitro, a carboxy, an alkoxycarbonyl of 2-7 carbon atoms, an alkanoyl of 2-7 carbon atoms, a phenoxy, a phenyl, a thiophenoxy, a benzoyl, a benzyl, an amino, an alkylamino of 1-6 carbon atoms, a dialkylamino of 2 to 12 carbon atoms, a phenylamino, a benzylamino, an alkanoylamino of 1-6 carbon atoms, an alkenoylamino of 3-8 carbon atoms, an alkynoylamino of 3-8 carbon atoms, a carboxyalkyl of 2-7 carbon atoms, a carboalkoxyalkyl of 3-8 carbon atoms, an aminoalkyl of 1-5 carbon atoms, an N-alkylaminoalkyl of 2-9 carbon atoms, a N,N-dialkylaminoalkyl of 3-10 carbon atoms, a N-alkylaminoalkoxy of 3-9 carbon atoms, a N,N-dialkylaminoalkoxy of 4-10 carbon atoms, a mercapto, a methylmercapto, an alkanoyloxy of 1-6 carbon atoms, an alkenoyloxy of 3-8 carbon atoms, an alkynoyloxy of 3-8 carbon atoms, a carbamoyl, an N-alkylcarbamoyl of 2-7 carbon atoms, a N,N-dialkylcarbamoyl of 3-13 carbon atoms, and a benzoylamino; m is 0; n is 0; X is NH; R is alkyl of 1-6 carbon atoms; R R R R a crystalline form or a pharmaceutically acceptable salt thereof.