Patent ID: 8815256
Filing Date: 2014-08-26
Classification: A61K,A61P,C07K

Abstract:
1. A method of inducing immunity against a cancer expressing folate binding protein (SEQ ID NO:10) in an individual, the method comprising administering to the individual an effective amount of a first peptide comprising the amino acid sequence of a variant of a peptide fragment of the polypeptide of SEQ ID NO: 10, wherein the peptide is of at least 9 amino acids or up to about 30 amino acids and is selected from the group consisting of: a) a peptide comprising the amino acid sequence of SEQ ID NO: 268 but for the substitution therein of amino acids at positions 5 and 7 thereof by phenylalanine and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; b) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acid at position 5 thereof by phenylalanine, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; c) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acids at positions 1, 5, 6, and 7 thereof by phenylalanine, phenylalanine, alanine, and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; d) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acids at positions 6 and 7 thereof by alanine and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; e) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acids at positions 1 and 7 thereof by phenylalanine and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; f) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acids at positions 1, 5, and 7 thereof by phenylalanine, phenylalanine, and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein; and g) a peptide comprising the amino acid sequence of SEQ ID NO:268 but for substitution therein of the amino acids at positions 1 and 7 thereof by glycine and threonine, respectively, and from 0 to 21 additional contiguous amino acids of SEQ ID NO: 10 that flank SEQ ID NO: 268 as contained therein.