Patent ID: 8257915
Filing Date: 2012-09-04
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method for identifying an agent that inhibits or reverses at least one cellular defect, wherein the at least one cellular defect comprises mis-localization of a farnesylated lamin, mis-localization of a non-farnesylated lamin, aggregation of lamin, nuclear lobulation, nuclear blebbing, cytoskeleton disruption, premature apoptosis, reduced secretion of MMP-3, or a combination of two or more thereof, the method comprising: contacting a cell expressing progerin or a progerin-like abnormal lamin A protein with a test agent under conditions sufficient to allow interaction between the cell and the agent; and determining whether the at least one cellular defect is inhibited or reversed.