Patent ID: 6660734
Filing Date: 2003-12-09
Classification: A61K,C07D,Y02P

Abstract:
A process for the production of a compound of the formula (I) or a pharmaceutically acceptable salt thereof, comprising condensation of a carboxyl-protected N-hydroxy alpha-amino acid with 3-hydroxy-protected-4-bromobutanoic acid, and removal of the protecting groups, wherein said compound of formula (I) is:wherein R is the side chain of a D- or L-alpha amino acid, R2 is OH, NH2 or NHCOR3; R3 is a substituent known to confer antibacterial activity when present in the side chain of penicillin or cephalosporin; R4 is H or lower alkyl; R5 is H, OH, NH2 or NHCOR3; R6 is H, OH, NH2 or NHCOR3 or R5 and R6 taken together comprise the oxygen of a carbonyl group.