Patent ID: 6528677
Filing Date: 2003-03-04
Classification: A61P,C07C,C07D

Abstract:
A retinoid, wherein the retinoid is a compound of formula I: whereinthe dotted bond is either present and forms a double bond, or is absent; R1, R2, R3, R4 are independently of each other hydrogen or alkyl; X is R8R9C<each R8 and each R9 is independendy hydrogen or alkyl; R5 is hydrogen, alkyl, alkoxy, alkoxy-alkyl-, alkythio, alkyl-NR10-, alkenyl, alkenyloxy, alkynyl, benzyl, cycloalkyl-alkyl, or phenyl-alkyl; R10 is hydrogen or alkyl; m is 0 when the dotted bond is present; and m is 1 when the dotted bond is absent; and Ar surrounded by hexagon shown above is phenyl and Y and â€”C(O)OR7 are para to each other; R6 is hydrogen, halogen, alkoxy or hydroxy; R7 is hydrogen or alkyl; and Y â€”COOâ€”, â€”OCOâ€”, â€”CONR10â€”, â€”NR10COâ€”, â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, â€”COCH&boxH;CHâ€”, â€”CHOHCH&boxH;CHâ€”, â€”CH2Oâ€”, â€”CH2Sâ€”, â€”CH2SOâ€”, â€”CH2SO2â€”, â€”CH2NR10â€”, â€”OCH2â€”, â€”SCH2â€”, â€”SOCH2â€”, â€”SO2CH2â€” or â€”NR10CH2â€”, with the proviso that when Y is â€”OCOâ€”, â€”NR10COâ€”, â€”OCH2â€”, â€”SCH2â€”, â€”SOCH2â€”, â€”SO2CH2â€” or â€”NR10CH2â€”, R5 is hydrogen, alkyl, , alkoxy-alkyl-, alkenyl, alkynyl, benzyl, cycloalkyl-alkyl or phenyl-alkyl; or where R7 is hydrogen, a pharmaceutically active salt of the compound.