Patent ID: 6969593
Filing Date: 2005-11-29
Classification: A61K,C07K,C12N

Abstract:
1. A method for the selective survival or selective growth of a bacterial target cell comprising the steps of: a) contacting the bacterial target cell with a conjugate compound A-B, wherein A is a selective antibody or antibody derivative recognizing the target cell and B is an enzyme able to inactivate an antibiotic, wherein said antibiotic inhibits the growth of the bacterial target cell; and b) contacting the bacterial target cell with the antibiotic; wherein said antibiotic is a β-lactam antibiotic, chloramphenicol, or an aminoglycoside, and/or wherein the enzyme is a β-lactamase, a chloramphenicol-acetyltransferase, an aminoglycoside-N-acetyltransferase, an aminoglycoside-O-nucleotidyltransferase, or an aminoglycoside-Q-phosphotransferase.