Patent ID: 6107315
Filing Date: 2000-08-22
Classification: A61K,A61P

Abstract:
A method of treating peripheral neuropathy in a patient suffering from peripheral neuropathy comprising administering to a patient an effective peripheral neuropathy treating amount of a composition having as the active agent a compound selected from the group consisting of alpha-phenyl t-butyl nitrone (PBN); 5,5-dimethyl pyrroline N-oxide (DMPO); alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN) and derivatives thereof selected from the group consisting of hydroxy PBNs, POBNs and DMPOs; PBN, POBN and DMPO esters; acetoxy PBNs, POBNs and DMPOs; alkyl PBNs, POBNs and DMPOs; alkoxy PBNs, POBNs and DMPOs; and phenyl PBNs, POBNs and DMPOs having spin trapping activity in vivo in tissue; anda pharmaceutically acceptable carrier therefor.