Patent ID: 6235061
Filing Date: 2001-05-22
Classification: A61F,A61L,C08G

Abstract:
A polymeric matrix for repair or replacement of bone formed of a biodegradable, biocompatible polyphosphazene formed from the repeat unit ##STR2##, wherein R is a side chain selected from the group consisting of aliphatic, aryl, aralkyl, alkaryl, carboxylic acid, heteroaromatic, carbohydrates, heteroalkyl, halogen, (aliphatic)amino, heteroaralkyl, di(aliphatic)amino, arylamino, diarylamino, alkylarylamino, oxyaryl, oxyaliphatic, oxyalkaryl, oxyaralkyl, thioaryl, thioaliphatic, NHC(O)O-(aryl or aliphatic), --O--[(CH.sub.2).sub.x O].sub.y --(CH.sub.2).sub.x NH.sub.2, --O--[(CH.sub.2).sub.x O].sub.y CH.sub.2).sub.x NH(CH2).sub.x SO.sub.3 H, and --O--[(CH.sub.2).sub.x O].sub.y -(aryl or aliphatic), wherein x is 1-8 and y is an integer of 1 to 20,wherein the matrix is a porous structure with pore dimensions of between 100 and 250 microns.