Patent ID: 8658794
Filing Date: 2014-02-25
Classification: A61P,C07D

Abstract:
1. A compound according to formula I or a pharmaceutically acceptable salt thereof wherein R1 is one or two groups independently selected from hydrogen, hydroxy, (1-6C)alkoxy, (1-6C)alkyl, halogen or cyano; R2 is H or (1-6C)alkyl; R3 is (R31)(R32)CH—O; or R3 is (3-7C)cycloalkoxy which is optionally substituted with one or more substituents selected from fluoro or hydroxy; or R3 is heteroaryl, which is optionally substituted with one or more substituents selected from R34, R35, R36, halogen, hydroxy or cyano; R31 is H or (1-5C)alkyl optionally substituted with one or more fluoro, hydroxy or (1-6C)alkoxy; R32 is (1-5C)alkyl optionally substituted with one or more fluoro; R34 is (1-6C)alkyl optionally substituted with one or more fluoro; R35 is (1-6C)alkoxy optionally substituted with one or more fluoro; R36 is hydrogen or (1-6C)alkyl optionally substituted with one or more fluoro; or R4 is (1-4C)alkyl, optionally substituted independently by one or more substituents selected from R8, fluoro or hydroxy; wherein m is 1, 2 or 3; n is 1, 2 or 3; r is 1 or 2; Y is CR5 or N; X is O, CHR6, C(R66)(R67), NR7 or C═O; Z is O or Z forms with R9a 5 or 6 membered heterocyclyl optionally substituted by R91; R5 is H or (1-6C)alkyl optionally substituted with one or more fluoro; R6 is R61, R62, R63, R65, H, hydroxy or fluoro; R7 is R71, R72, R73, R74 or H; R8 is heteroaryl, optionally substituted with one or more groups selected from (1-4C)alkyl, hydroxy, (1-6C)alkoxy, amino, (di)[(1-4C)alkyl]amino, [(1-4C)alkyl]amino or halogen; R9 is H or (1-6C)alkyl optionally substituted with one or more fluoro; R61 is (1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-3C)alkyl, amino(1-4C)alkyl, [(1-6C)alkyl]amino(1-4C)alkyl, (di)[(1-6C)alkyl]amino(1-4C)alkyl, [(1-4C)alkylcarbonyl]amino(1-4C)alkyl, [(1-4C)alkyl][(1-4C)alkylcarbonyl]amino(1-4C)alkyl, [(1-4C)alkoxycarbonyl]amino(1-4C)alkyl or [(1-4C)alkyl][(1-4C)alkoxycarbonyl]amino(1-4C)alkyl, all of the alkyl groups of R61 are optionally substituted with one or more fluoro; R62 is (1-6C)alkoxy, hydroxy(1-6-C)alkoxy, (1-3C)alkoxy(2-4C)alkoxy, R621-(2-4C)alkoxy, (1-4C)alkylcarbonyloxy, (1-4C)alkylaminocarbonyloxy or (3-6C)cycloalkylaminocarbonyloxy, all of the alkyl groups of R62 are optionally substituted with one or more fluoro; R63 is amino, [(1-6C)alkyl]amino, (di)[(1-6C)alkyl]amino, [hydroxy(2-6C)alkyl]amino, [(1-6C)alkyl][hydroxy(2-6C)alkyl]amino, (1-6C)alkoxycarbonylamino, (1-6C)alkylaminocarbonylamino, [(1-6C)alkoxy(2-6C)alkyl]amino, [(1-6C)alkyl][(1-6C)alkoxy(2-6C)alkyl]amino, (1-6C)alkylcarbonylamino or [(1-6C)alkylcarbonyl][(1-6C)alkoxy(2-6C)alkyl]amino, all of the alkyl groups of R63 are optionally substituted with one or more fluoro; R65 is N-attached heterocyclyl which is optionally substituted with one or more oxo, fluoro or one or more R651; R66 is (1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-3C)alkyl, amino(1-4C)alkyl, [(1-6C)alkyl]amino(1-4C)alkyl, (di)[(1-6C)alkyl]amino(1-4C)alkyl, [(1-4C)alkylcarbonyl]amino(1-4C)alkyl, [(1-4C)alkyl][(1-4C)alkylcarbonyl]amino(1-4C)alkyl, [(1-4C)alkoxycarbonyl]amino(1-4C)alkyl, [(1-4C)alkyl][(1-4C)alkoxycarbonyl]amino(1-4C)alkyl, all of the alkyl groups of R66 are optionally substituted with one or more fluoro; R67 is hydroxy, (1-4C)alkoxy or fluoro; R71 is (1-6C)alkyl, (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-3C)alkyl, any of which is optionally substituted with one or more fluoro; R72 is (1-4C)alkyl, which is substituted with one group selected from R721, R722, R724 and R725; R73 is R732-carbonyl, R733-carbonyl, or R735-carbonyl; R74 is heterocyclyl which is optionally substituted with one or more groups independently selected from fluoro or R741; R91 is (1-6C)alkyl optionally substituted with one or more fluoro; R621 is amino, [(1-6C)alkyl]amino, (di)[(1-6C)alkyl]amino, any of the alkyl groups is optionally substituted with one or more fluoro; or R621 is N-attached heterocyclyl, optionally substituted with one or more fluoro; R651 is (1-4C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-3C)alkyl or (1-4C)alkylcarbonyl, all of the alkyl groups of R651 are optionally substituted with one or more groups independently selected from fluoro or hydroxy; R721 is (1-6C)alkoxy, (3-6C)cycloalkoxy, (1-6C)alkoxy-(3-6C)cycloalkyl, (1-3C)alkoxy(2-4C)alkoxy, amino(2-4C)alkoxy, [(1-6C)alkyl]amino(2-4C)alkoxy, (di)[(1-6C)alkyl]amino(2-4C)alkoxy, [hydroxy(2-6C)alkyl]amino(2-4C)alkoxy, [(1-6C)alkyl][hydroxy(2-6C)alkyl]amino(2-4C)alkoxy, [(1-6C)alkoxy(2-6C)alkyl]amino(2-4C)alkoxy, [(1-6C)alkyl][(1-6C)alkoxy(2-6C)alkyl]amino(2-4C)alkoxy, (cyclyl-N)-(2-4C)alkoxy, [(1-6C)alkylcarbonyl]amino(1-6C)alkoxy, [(1-6C)alkyl][(1-6C)alkylcarbonyl]amino(1-6C)alkoxy, [(3-6C)cycloalkylcarbonyl]amino(1-6C)alkoxy, [(1-6C)alkyl][(3-6C)cycloalkylcarbonyl]amino(1-6C)alkoxy, aminocarbonyl(1-6C)alkoxy, [(1-6C)alkyl]aminocarbonyl(1-6C)alkoxy, (di)[(1-6C)alkyl]aminocarbonyl(1-6C)alkoxy, [hydroxy(1-6C)alkyl]aminocarbonyl(1-6C)alkoxy or (cyclyl-N)carbonyl(1-6C)alkoxy, all of the alkyl groups of R721 are optionally substituted with one or more groups independently selected from fluoro or hydroxy; R722 is amino, [(1-6C)alkyl]amino, (di)[(1-6C)alkyl]amino, [hydroxy(2-6C)alkyl]amino, [(1-6C)alkyl][hydroxy(2-6C)alkyl]amino, [(1-6C)alkoxy(2-6C)alkyl]amino, [(1-6C)alkyl][(1-6C)alkoxy(2-6C)alkyl]amino or cyclyl-N, all of the alkyl groups of R722 are optionally substituted with one or more fluoro; R724 is (1-6C)alkoxycarbonylamino, [(1-6C)alkoxycarbonyl(1-6C)alkyl]amino, (1-6C)alkylaminocarbonylamino, (cyclyl-N)carbonylamino; R725 is aminocarbonyl, [(1-6C)alkyl]aminocarbonyl, (di)[(1-6C)alkyl]aminocarbonyl, [hydroxy(2-6C)alkyl]aminocarbonyl, [(1-6C)alkyl][hydroxy(2-6C)alkyl]aminocarbonyl, [(1-6C)alkoxy(2-6C)alkyl]aminocarbonyl, [(1-6C)alkyl][(1-6C)alkoxy(2-6C)alkyl]aminocarbonyl, (cyclyl-N)carbonyl, amino(2-4C)alkoxycarbonyl or [(1-6C)alkyl]amino(2-4C)alkoxycarbonyl, all of the alkyl groups of R725 are optionally substituted with one or more fluoro; R732 is (1-4C)alkyl, amino(1-4C)alkyl, [(1-6C)alkyl]amino(1-4C)alkyl, (di)[(1-6C)alkyl]amino(1-4C)alkyl, [hydroxy(2-6C)alkyl]amino(1-4C)alkyl, [(1-6C)alkyl][hydroxy(2-6C)alkyl]amino(1-4C)alkyl, [(1-6C)alkoxy(2-6C)alkyl]amino(1-4C)alkyl, [(1-6C)alkyl][(1-6C)alkoxy(2-6C)alkyl]amino(1-4C)alkyl, (cyclyl-N)(1-4C)alkyl, [(1-6C)alkylcarbonyl]amino(1-4C)alkyl, [(1-6C)alkyl][(1-6C)alkylcarbonyl]amino(1-4C)alkyl, hydroxy(1-4C)alkyl, (1-6C)alkoxy(1-4C)alkyl, (3-6C)cycloalkoxy(1-4C)alkyl, aminocarbonyl(1-4C)alkyl, [(1-6C)alkyl]aminocarbonyl(1-4C)alkyl, (di) [(1-6C)alkyl]aminocarbonyl(1-4C)alkyl, [hydroxy(1-6C)alkyl]aminocarbonyl(1-4C)alkyl, [(1-6C)alkyl][hydroxy(1-6C)alkyl]aminocarbonyl(1-4C)alkyl or [(1-6C)alkoxy(2-6C)alkyl]aminocarbonyl(1-4C)alkyl, all of the alkyl groups of R732 are optionally substituted with one or more fluoro; R733 is (1-6C)alkoxy; R735 is amino, [(1-6C)alkyl]amino, (di)[(1-6C)alkyl]amino or cyclyl-N, all of the alkyl groups of R735 are optionally substituted with one or more fluoro; R741 is (1-4C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-3C)alkyl, (1-6C)alkoxy or (1-4C)alkylcarbonyl all, of the alkyl groups of R741 are optionally substituted with one or more fluoro or hydroxy.