Patent ID: 6737429
Filing Date: 2004-05-18
Classification: A61P,C07D

Abstract:
A compound of formula I or the hydrolyzable esters or ethers of such compound, or a pharmaceutically acceptable salt thereof,wherein R1 is methyl or ethyl substitute with pyridinyl; R2 is alkyl, cycloalkyl, aryl; R3 is hydrogen, alkyl, cycloalkyl, or aryl; R4 is hydrogen, alkyl, carboxyl, C(&boxH;O)R, CONRâ€²Râ€³, cyano or alkenyl; R is hydrogen, alkyl, alkoxy, trifluoromethyl, methyl-oxy-carbonyl or ethyl-oxy-carbonyl; Râ€² and Râ€³, are each independently selected from hydrogen, alkyl or aryl; R5 is alkyl, aryl or a group â€”Zâ€”C(&boxH;O)Râ€²â€³; Z is a single bond or â€”CH&boxH;CHâ€”; Râ€²â€³ is hydrogen or alkyl; and X represents S, S(O), S(O)2, or O; and provided that only one of R3 and R4 is hydrogen.