Patent ID: 6423511
Filing Date: 2002-07-23
Classification: A61K,A61P,C07K,Y10S

Abstract:
An isolated nucleic acid sequence encoding an amino acid sequence of the H chain and L chain variable regions of a human CDR-grafted antibody containing a framework, FR, Kabat's Human sub Group, HSG, which comprises an amino acid sequence in which at least one amino acid of positions 38, 40, 67, 72, 84 and 98 in the FR of H chain variable region and positions 4, 11, 15, 35, 42, 46, 59, 69, 70, 71, 72, 76, 77 and 103 in the FR of L chain variable region is replaced with another amino acid and a complementary determinant region, CDR, of a heavy chain having the amino acid sequences as set forth in SEQ ID NO:105, SEQ ID NO:106 and SEQ ID NO:107 and a light chain having the amino acid sequences as set forth in SEQ ID NO:108, SEQ ID NO:109 and SEQ ID NO:h110.