Patent ID: 6211250
Filing Date: 2001-04-03
Classification: A61K,A61P,Y10S

Abstract:
A substantially homogenous liquid composition capable of percutaneous delivery of one more physiologically active agents, the composition comprising at least one physiologically active agent, a volatile solvent, and a rate modulating carrier, said rate modulating carrier consisting essentially of(i) a hydrophilic polymer selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolldone, carbomer, PVM/MA decadiene cross polymer and hydroxypropylguar and copolymers thereof, said hydrophilic polymer being present in an amount of from 0.001 to 50% w/w of the total liquid composition and(ii) a hydrophobic polymer selected from the group consisting of octylacrylamide, octylpropenamide acrylate copolymer, aminoalkyl methacrylate copolymer, ammonio methacrylate copolymer, PVP/VA copolymer, PVA, PVM/MA butylester copolymer, shellac and alkyl acrylates and copolymers thereof, said hydrophobic polymer being present in an amount of from 0.001 to 50% w/w of the total liquid composition,the combination of hydrophilic and hydrophobic polymers being selected to enable modulation of the rate of delivery of said physiologically active ingredient.