Patent ID: 6865407
Filing Date: 2005-03-08
Classification: A61B

Abstract:
1. A method of calibrating a non-invasive sensor for a first physiologic parameter in tissue, comprising: (a) non-invasively measuring first values of the first physiologic parameter and of a second physiologic parameter in the tissue, a known relationship existing between the first and second physiologic parameters; (b) acting on the tissue so as to change the first and second physiologic parameters; (c) non-invasively measuring second values of the first physiologic parameter and of the second physiologic parameter in the tissue, the measurements of the first and second values of the second physiologic parameter being absolutely calibrated; and (d) determining a calibrated value for at least one of the first and second values of the first physiologic parameter from the first and second values of both the first and second physiologic parameters; wherein non-invasively measuring the first values of the first physiologic parameter includes exciting the tissue with excitation light and detecting a resulting fluorescent signal.