Patent ID: 9186318
Filing Date: 2015-11-17
Classification: A61K,A61P,C07D

Abstract:
1. A quinolyl-containing hydroxamic acid compound, having the molecular structure of formula (I) below: wherein, either of V either of R or R′ is a hydroxamic acid-containing Q group and the other is a hydrogen, methoxy, methoxyethoxy or the hydroxamic acid-containing Q group, wherein the hydroxamic acid-containing Q group is A is O, NH, S(═O) L is C J is O, NH, S(═O) X is —C(═O)—, —S(O) Y is C wherein, each of G 1 , G 2 , G 3 , Wand G 5 is H, —CN, —CF 3 , —CO 2 H, halogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6 aryl, C 5-6 heteroaryl, C 3-12 heteroalicyclyl, R 1 O—, R 1 R 2 N—, R 1 S(═O) m —, R 1 R 2 NS(═O) m —, R 3 C(═O)—, R 1 R 2 NC(═O)—, R 1 OC(═O)—, R 3 C(═O)O—, R 1 R 2 NC(═O)O—, R 3 C(═O)NR 1 —, R 1 R 2 NC(═O)NR 4 —, R 1 OC(═O)NR 4 —, R 1 S(═O) m NR 4 —, R 1 R 2 NS(═O) m NR 4 —, R 1 R 2 NC(═NR 5 )NR 4 —, R 1 R 2 NC(═CHNO 2 )NR 4 —, R 1 R 2 NC(═N—CN)NR 4 —, R 1 R 2 NC(═NR 5 )—, R 1 S(═O)(═NR 5 )NR 4 — or R 1 R 2 NS(═O)(═NR 5 )—; each of R m=0-2.