Patent ID: 7462733
Filing Date: 2008-12-09
Classification: A61P,C07F,C07H

Abstract:
1. A method of preparing an α-keto phosphonate of the formula the method comprising: i) forming a reaction mixture comprising a rhodium(II) catalyst, an alkene oxide and an α-diazo phosphonate having formula IV: wherein X is selected from the group consisting of —C(═O)OR3, —C(═O)N(R4)(R5), and —P(═O)(OR6)(R7), wherein R1, R2 R3, R4, R5 and R6 and each independently selected from the group consisting of alkyl, and aryl; R7 is selected from the group consisting of alkyl, aryl, and OR8, wherein R8 is selected from the group consisting of alkyl, aryl and nucleosidyl; and ii) oxidizing the α-diazo phosphonate to form an α-keto phosphonate.