Patent ID: 6080867
Filing Date: 2000-06-27
Classification: C07D,Y02P

Abstract:
A process for the manufacture of a compound of formula I ##STR29## wherein R.sub.4 and R.sub.6 are each independently H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl or substituted phenyl;R.sub.5 is H; halogen; C.sub.1 -C.sub.6 alkyl optionally substituted with one or more C.sub.1 -C.sub.4 alkoxy groups; C.sub.1 -C.sub.6 alkenyl; phenyl or substituted phenyl; andR.sub.2 and R.sub.3 are each independently C.sub.1 -C.sub.6 alkyl, phenyl or substituted phenyl;which comprises reacting a compound of formula II or an alkali metal salt thereof ##STR30## wherein X is O or S; R.sub.1 is C.sub.1 -C.sub.6 alkyl, phenyl or substituted phenyl; and R.sub.2 and R.sub.3 are as described for formula I; with at least one molar equivalent of a compound of formula III ##STR31## wherein R.sub.4, R.sub.5 and R.sub.6 are as described for formula I; and an ammonia source in the presence of a solvent optionally at an elevated temperature.