Patent ID: 8884028
Filing Date: 2014-11-11
Classification: C07C,C07D

Abstract:
1. A process for preparing a compound of formula III wherein R comprising a) reacting compounds of formula (IV), (V) and (VI) wherein R wherein M is a lithium, sodium or potassium ion and R wherein R to form an enolate of formula VII wherein M is as defined for formula V and R b) releasing the compound of formula VIII wherein R from the enolate of formula VII by means of an acid, c) converting the compound of formula VIII, in the presence of the salt formed from cation M and the anion of the acid in step b), to a compound of formula II, wherein R d) reacting the compound of formula II with methylhydrazine in the presence of water to form a compound of formula III e) separating the compound of formula III from the salt formed from cation M and the anion of the acid in step b) wherein step d) is carried out in the presence of a water-immiscible solvent and in step e) the compound of formula III is separated from the salt by separating the organic phase containing the compound of formula III from the aqueous phase containing the salt.