Patent ID: 6545051
Filing Date: 2003-04-08
Classification: A61K,A61P

Abstract:
A method for the treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterial effective dose of a compound of formula (I): wherein:R1 represents hydrogen, hydroxy, amino, methyl, or trifluoromethyl; R2 represents a group R10â€”(X)nâ€”(ALK)â€” wherein R10 represents hydrogen, a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, trifluoromethyl, cyano, nitro, â€”COOH, â€”CONH2, â€”COORA, â€”NHCORA, â€”CONHRA, â€”NHRA, â€”NRARB, or â€”CONRARB wherein RA and RB are independently a (C1-C6)alkyl group, and ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent â€”NHâ€”, â€”Oâ€” or â€”Sâ€” linkages, X represents â€”NHâ€”, â€”Oâ€” or â€”Sâ€”, and n is 0 or 1; R represents hydrogen or C1-C6 alkyl, R3 represents the characterising group of a natural or non-natural a amino acid in which any functional groups may be protected; and R4 represents an ester or thioester group, or a pharmaceutically acceptable salt, hydrate or solvate thereof.