Patent ID: 6310060
Filing Date: 2001-10-30
Classification: C07C,C07D

Abstract:
The compounds of Formula I ##STR12##wherein:R.sub.1 is hydrogen, hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, halo, trifluoromethyl, or CN;R.sub.2 is hydrogen;R.sub.3, R.sub.4, and R.sub.5 independently are hydrogen, hydroxy, halo, trifluoromethyl, C.sub.1 -C.sub.8 alkyl, CN, or --(O or NH).sub.m --(CH.sub.2).sub.n --R.sub.9, where R.sub.9 is hydrogen, hydroxy, COOH, or NR.sub.10 R.sub.11 ;n is 0-4;m is 0 or 1;R.sub.10 and R.sub.11 independently are hydrogen or C.sub.1 -C.sub.8 alkyl, or taken together with the nitrogen to which they are attached can complete a 3-10 member cyclic ring optionally containing 1, 2, or 3 additional heteroatoms selected from O, S, NH, or N--C.sub.1 -C.sub.8 alkyl;Z is COOR.sub.7, tetrazolyl, CONR.sub.6 R.sub.7, or CH.sub.2 OR.sub.7 ;R.sub.6 and R.sub.7 independently are hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl,C.sub.2 -C.sub.8 alkynyl, ##STR13##aryl, heteroaryl, C.sub.3 -C.sub.10 cycloalkyl, orC.sub.3 -C10 cycloalkyl, optionally containing one, two, or three heteroatoms selected from O, S, NH, or N alkyl; or R.sub.6 and R.sub.7 together with the nitrogen to which they are attached complete a 3-10 member cyclic ring optionally containing 1, 2, or 3 additional heteroatoms selected from O, S, NH, or N alkyl; and wherein any of the foregoing alkyl, alkenyl, and alkynyl groups can be unsubstituted or substituted by halo, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cycloalkyl, aryl, aryloxy, heteroaryl, or heteroaryloxy, and the pharmaceutically acceptable salts thereof.