Patent ID: 6113919
Filing Date: 2000-09-05
Classification: A61K,B01F,Y10S

Abstract:
A composition in the form of an oil-in-water emulsion, comprising:a continuous aqueous phase; anda discontinuous phase comprising:an amphiphilic surfactant with a hydrophilic part and a lipophilic part, or a mixture of such surfactants;0.01-10% w/v of a lipophilic/fluorophilic compound with a lipophilic part and a fluorophilic part wherein said lipophilic part comprises a linear, branched or cyclic saturated or unsaturated alkyl group having between 4 and 18 carbon atoms, the lipophilic/fluorophilic compound being present in an effective molar ratio to the surfactant to impart the composition with enhanced particle size stability; anda fluorocarbon liquid, wherein said fluorocarbon liquid is different than said lipophilic/fluorophilic compound;wherein the discontinuous phase is in the form of discrete droplets of said fluorocarbon liquid comprising an outer layer of the amphiphilic surfactant oriented such that the hydrophilic part thereof is substantially associated with and the lipophilic part thereof is substantially associated with the lipophilic part of the stabilizing compound, the fluorophilic part of the stabilizing compound being substantially associated with the fluorocarbon liquid.