Patent ID: 6468548
Filing Date: 2002-10-22
Classification: A61K,A61P,Y10S

Abstract:
A method for stabilizing an ophthalmic composition comprising dexamethasone, ketotifen or an ophthalmically acceptable salt of ketotifen, comprising:admixing an ophthalmically acceptable carrier, a drug selected from dexamethasone, ketotifen, and an ophthalmically acceptable salt of ketotifen and an amount of a stabilizer selected from the group consisting of ethylenediamine tetraacetic acid, salts of ethylenediamine tetraacetic acid, desferoxamine, salts of desferoxamine, chelating agents having phosphonic acid groups, and chelating agents having phosphonate groups, wherein said amount of stabilizer is sufficient to stabilize the drug against decomposition upon autoclaving, to provide a mixture; and autoclaving said mixture.