Patent ID: 6861522
Filing Date: 2005-03-01
Classification: C07D

Abstract:
1. A process for the preparation of a compound of the formula and optionally its E/Z-isomers, E/Z-isomer mixtures and/or tautomers, in each case in free form or in salt form, in which Q is CH or N; Y is NO Z is CHR R R R R a) a compound of the formula  which is known or can be prepared by known methods, and in which X is a leaving group, is reacted with a halogenating agent to give a compound of the formula  In which W is a halogen atom, or optionally a tautomer, in each case in free form or in salt form; and in which the work-up of the compound of formula (III) involves an extraction of the compound of formula (III) with hydrochloric acid of concentration between 10 and 50% by weight; and b) the resulting compound of the formula (III) is reacted with a compound of the formula  in which R wherein the preparation of the compound of the formula (III) according to process stage a) involves a purification step in which the crude product which has formed is treated with water in the acidic pH range.