Patent ID: 6559164
Filing Date: 2003-05-06
Classification: C07D

Abstract:
A compound having the formula and pharmaceutically active salts of said compounds, wherein:R is selected from the group consisting of â€”CH2OPO3R1R2, â€”CH2OHâ€”CH2OCOR3, â€”H2OCO2R3, â€”CH2OCONHR3, and â€”CONHR3; R1 and R2 are selected from the group consisting of H, Na and NH4 and are the same unless either R1 or R2 is H, in which case the other can be different, or alternatively, R1 and R2 together represent calcium; R3 is selected from the group consisting of alkyl which optionally may be substituted by one or more substituents selected from the group consisting of â€”CO2R4, â€”NR5R6, polyethylene glycol, â€”OPO3R1R2, hydroxy, alkoxy and aryl; alkenyl which optionally may be substituted by one or more substituents selected from the group consisting of â€”CO2R4, â€”NR5R6, polyethylene glycol, â€”OPO3R1R2, hydroxy, alkoxy and aryl; cycloalkyl which optionally may be substituted by one or more substituents selected from the group consisting of â€”CO2R4, â€”NR5R6, polyethylene glycol, â€”OPO3R1R2, hydroxy, alkoxy and aryl, heterocycle, which when having N as a heteroatom, the N optionally may be substituted with the group consisting of lower alkyl and â€”COR7, and aryl which optionally may be substituted by one or more substituents selected from the group consisting of CO2R4, hydroxy, alkoxy, polyethylene glycol, OPO3R1R2, and alkyl which itself may be substituted with hydroxy alkoxy, carboxy and substituted amino, provided that when aryl represents pyridine, the nitrogen may be substituted with lower alkyl; R4 is selected from the group consisting of H, Na and lower alkyl; R5 and R6 are each independently selected from the group consisting of H, lower alkyl, and â€”COR7, or alternatively, the group â€”NR5R6 together form a 5 or 6 membered heterocyclic ring; and R7 is lower alkyl which optionally may be substituted with carboxy, polyethylene glycol, and substituted amino.