Patent ID: 6255301
Filing Date: 2001-07-03
Classification: A61P,C07D

Abstract:
A compound of formula I, ##STR16##whereinR.sup.1 represents H, C(O)R.sup.11, SiR.sup.12 R.sup.13 R.sup.14 or C.sub.1-6 alkyl which latter group is optionally substituted or terminated by one or more substituent selected from OR.sup.15 or (CH.sub.2).sub.q R.sup.16 ;R.sup.12, R.sup.13, and R.sup.14, independently represent H, phenyl or C.sub.1-6 alkyl;R.sup.16 represents C.sub.1-4 alkyl, phenyl, OH, C(O)OR.sup.17 or C(O)N(H)R.sup.18 ;R.sup.18 represents H, C.sub.1-4 alkyl or CH.sub.2 C(O)OR.sup.19 ;R.sup.15 and R.sup.17 independently represent H, C.sub.1-6 alkyl or C.sub.7-9 alkylphenyl;R.sup.11 and R.sup.19 independently represent H or C.sub.1-4 alkyl; andq represents 0, 1 or 2;R.sup.2 and R.sup.3 independently represent H, C.sub.1-4 alkyl, cyclohexyl or phenyl;R.sup.x represents a structural fragment of formula IIa, IIb or IIc, ##STR17##whereink, l and m independently represent 0, 1, 2, 3 or 4;R.sup.4 and R.sup.5 independently represent H, Si(Me).sub.3, 1- or 2-naphthyl, a polycyclic hydrocarbyl group, CHR.sup.41 R.sup.42 or C.sub.1-4 alkyl, which latter group is optionally substituted by one or more fluorine atoms, or C.sub.3-8 cycloalkyl phenyl, methylenedioxyphenyl, benzodioxanyl, benzofuranyl, dihydrobenzofuranyl, benzothiazolyl, benzoxazolyl, benzimidazolyl, coumaranonyl, coumarinyl or dihydrocoumarinyl, which latter twelve groups are optionally substituted by one or more of C.sub.1-4 alkyl, which latter group is optionally substituted by one or more halo substituents, C.sub.1-4 alkoxy, halo, hydroxy, cyano, nitro, SO.sub.2 NH.sub.2, C(O)OH or N(H)R.sup.43 ;R.sup.41 and R.sup.42 independently represent cyclohexyl or phenyl;R.sup.6 and R.sup.7 independently represent H, C.sub.1-4 alkyl, C.sub.3-8 cycloalkyl, phenyl which latter group is optionally substituted by one or more of C.sub.1-4 alkyl, which latter group is optionally substituted by one or more halo substituents, C.sub.1-4 alkoxy, halo, hydroxy, cyano, nitro, SO.sub.2 NH.sub.2, C(O)OH or N(H)R.sup.44) or together with the carbon atom to which they are attached form a C.sub.3-8 cycloalkyl ring;R.sup.43 and R.sup.44 independently represent H or C(O)R.sup.45 ; andR.sup.45 represents H, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;Y represents CH.sub.2 ;n represents 0, 1, 2, 3 or 4; andB represents a structural fragment of formula IVa, IVb or IVc ##STR18##whereinX.sup.1 and X.sup.2 independently represent CH.sub.2 ;or a pharmaceutically acceptable salt thereof.