Patent ID: 8065093
Filing Date: 2011-11-22
Classification: C12Q,G16B,G16H,Y02A

Abstract:
1. A method for predicting disease outcome, the method comprising the steps of: obtaining gene expression profiles from a plurality of genes from tumor samples, wherein said tumor samples may be mutant or wildtype for the p53 gene; comparing said gene expression profiles to determine which genes are differentially expressed in the tumor samples that may be mutant or wild type for the p53 gene; deriving from said differentially expressed genes a set of sequences to predict p53 mutational status; and assessing the ability of the set of sequences based on microarray analysis and Kaplan-Meier analysis to predict disease outcome, wherein the sequences consist of SEQ ID NO: 22, SEQ ID NO: 31, SEQ ID NO: 11, SEQ ID NO: 9, SEQ ID NO: 1, SEQ ID NO: 29, SEQ ID NO: 28, SEQ ID NO: 5 and SEQ ID NO: 25 and wherein the disease is late-stage breast cancer.