Patent ID: 6028110
Filing Date: 2000-02-22
Classification: A61P,C07C,Y10S

Abstract:
A pharmaceutical or veterinary composition comprising a compound of formula I ##STR35## wherein X is a --CO.sub.2 H group;R.sub.1 is hydrogen;R.sub.2 represents a linear saturated or unsaturated C.sub.13 -C.sub.24 hydrocarbon chain, wherein the hydrocarbon chain(i) may be interrupted by one or more non-adjacent --O-- or --S-- atoms or --C(.dbd.O)--, --S(.fwdarw.O)--, --S(.dbd.O).sub.2 -- or N(R.sub.x)-- groups wherein R.sub.x is hydrogen, methyl or ethyl, provided that the maximum length of the chain is no more than 28 C, O, S and N atoms, and/or(ii) may be substituted with one or more groups selected from C.sub.1 -C.sub.6 alkyl, OH, OMe, halogen, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2, CO.sub.2 H, CO.sub.2 CH.sub.3, COCH.sub.3, CHO, CONH.sub.2, CONHCH.sub.3, CON(CH.sub.3).sub.2, CH.sub.2 OH, NHCOCH.sub.3, provided that the maximum length of the chain is no more than 28 C, O, S and N atoms;R.sub.3 is the characterizing side chain of a natural or non-natural .alpha. amino acid in which any functional groups may be protected, with the proviso that R.sub.3 does not represent hydrogen;R.sub.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, (C.sub.1 -C.sub.4)perfluoroalkyl or a group D-(C.sub.1 -C.sub.6 alkyl) wherein D represents hydroxy, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio, acylamino, optionally substituted phenyl or heteroaryl, NH.sub.2, or mono or di-(C.sub.1 -C.sub.6) alkyl amino;R.sub.5 is hydrogen or a (C.sub.1 -C.sub.6)alkyl group;or a salt, hydrate or solvate thereof, and a pharmaceutically or veterinarily acceptable excipient or carrier.