Patent ID: 9028806
Filing Date: 2015-05-12
Classification: A61K,A61P,Y02A

Abstract:
1. Batch method for impregnating a polymeric pharmaceutical carrier with an active substance, wherein it comprises the following consecutive steps: a) mixing the active substance and the non-porous polymeric pharmaceutical carrier chosen from disintegrating agents, filler agents, or mixtures thereof, the pharmaceutical carrier being in solid form and insoluble in supercritical CO b) performing a molecular diffusion step in the absence of water by contacting, in static mode without stirring, the mixture obtained in step a) with supercritical CO c) recovering the polymeric pharmaceutical carrier impregnated with the active substance obtained in step b), the impregnated pharmaceutical carrier being non-porous and being in solid form and the active substance being in amorphous form, and in that the method is implemented in the absence of an additional solvent.