Patent ID: 7713538
Filing Date: 2010-05-11
Classification: A61F,A61L,A61P,Y10T

Abstract:
1. An intravascular stent comprising a metal body having a coating comprising a polymer and a restenosis inhibiting agent, wherein the restenosis inhibiting agent is a sparingly water soluble matrix metallo-proteinase inhibitor (MMPI) and the polymer in the coating is a cross-linked amphiphilic polymer formed from an ethylenically unsaturated zwitterionic monomer comprising a hydrophilic zwitterionic group; an ethylenically unsaturated hydrophobic monomer comprising a pendant hydrophobic group; and an ethylenically unsaturated reactive monomer comprising a pendant reactive group capable of forming intermolecular cross-linkers, wherein the zwitterionic monomer has the general formula I: wherein B is a straight or branched alkylene, alkyleneoxaalkylene or alkylene oligo-oxaalkylene chain optionally containing one or more fluorine atoms or, if X or Y contains a terminal carbon atom bonded to B, a valence bond; X is a zwitterionic group; and Y is an ethylenically unsaturated polymerisable group selected from  CH wherein: R is hydrogen or a C R R K is a group selected from —(CH p is from 1 to 12; and R