Patent ID: 6537749
Filing Date: 2003-03-25
Classification: B01J,B82Y,C03C,C07B,C07K,C12Q,C40B,G01N

Abstract:
A method for generating an addressable array of molecules, said method comprising:(a) providing a solid support having a linker layer on its surface, said linker layer linking to derivatized capture probes, each of said capture probes comprising a non-nucleosidic spacer group located proximal to the linker layer and an oligonucleotide sequence located distal to the linker layer, said capture probes immobilized as an array on said solid support, wherein said oligonucleotide sequence is complementary to that of an addressable molecule; and (b) contacting said solid support with a population of addressable molecules whereby said addressable molecules orient themselves on said solid support by sequence-dependent recognition of and binding to said oligonucleotide sequences of said capture probes, wherein an addressable array of molecules is generated.