Patent ID: 7432403
Filing Date: 2008-10-07
Classification: A61P,C07F

Abstract:
1. A cyclopalladated compound, which is an organometallic compound comprising palladium, a Sigma C—Pd bond and a coordination bond Y→Pd, originating an organic cycle with formula corresponding to the structure below: wherein: X represents an element chosen from the group consisting of: halogen; pseudo-halogen and acetate; and Y is a nitrogen atom (N) within a moiety selected from the group consisting of N,N-dimethyl-1-phenethylamine (dmpa), pyridinyl-phenyl-ethyne, 1-phenyl-3-N,N-dimethylamine-propyne; C is selected from the group consisting of a carbon atom at the ortho position of the dmpa, a carbon atom within the pyridinyl-phenyl-ethyne, a carbon atom within the 1-phenyl-3-N,N-dimethylamine-propyne; and the carbon atom is covalently bonded to the atom of palladium; the ring containing C, Y and Pd can be constituted of three to eight atoms; between C and Y, represented by a curved line, there is a succession of atoms designated as a cyclopalladated ring; L represents a coordinated ligand which is a donating atom from group V of the Periodic Table (N, P, As, Sb, Bi) within a bis-diphenylphosphine-ferrocene compound as detailed by Scheme 2 below, with the schematic representation L-L indicating the presence of two linkers L within the structure of said bis-diphenylphosphine-ferrocene compound, while R1 and R2 are each phenyl groups, and R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are individually selected from the group consisting of the following radicals, which can be present in any order: hydrogen (H), alkyl, aryl, dienyl, alkoxy, siloxy, hydroxy (OH), amine (—NH2), imide, halogen (F, Cl, Br, I), imine, and nitro (—NO2); or a pharmaceutically acceptable salt or adduct of the cyclopalladated compound.