Patent ID: 6685933
Filing Date: 2004-02-03
Classification: A61K,C07K

Abstract:
A purified hybrid interferon-&agr; polypeptide, comprisinga first amino acid sequence consisting of residues 1-75 of interferon-&agr;2c; a second amino acid sequence consisting of residues 76-81 of interferon-&agr;2c or residues 76-81 of interferon-&agr;21a; a third amino acid sequence consisting of the sequence LDKFXTELXQQLND or the sequence LEKFXTELXQQLND, wherein X is any amino acid residue; and a fourth amino acid sequence consisting of residues 96-166 of interferon-&agr;21a; wherein the C-terminal residue of the first amino acid sequence is fused to the N-terminal residue of the second amino acid sequence; and the C-terminal residue of the second amino acid sequence is fused to the N-terminal residue of the third amino acid sequence; and the C-terminal residue of the third amino acid sequence is fused to the N-terminal residue of the fourth amino acid sequence; and wherein the hybrid interferon-&agr; polypeptide has interferon-&agr; protein biological activity.