Patent ID: 8129352
Filing Date: 2012-03-06
Classification: A61P,C07K,C12N

Abstract:
1. A method of inhibiting replication of a Flaviviridae positive strand RNA virus selected from yellow fever virus, Dengue virus, tick born encephalitis virus, and West Nile virus, comprising: administering to mammalian host cells a virus-inhibitory amount of an antisense oligonucleotide analog characterized by (i) a nuclease-resistant backbone, (ii) being capable of uptake by mammalian host cells, (iii) containing up to 25 nucleotide bases, (iv) being composed of morpholino subunits linked by phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, and (v) having a targeting sequence that comprises the sequence set forth in SEQ ID NO:47, 49, 51, or 55, wherein the antisense oligonucleotide analog disrupts a stem-loop structure in the 5′-terminal region of the RNA virus and inhibits virus production.