Patent ID: 6645971
Filing Date: 2003-11-11
Classification: A61P,C07D

Abstract:
A method for treating urinary incontinence or pollakiuria, which comprises administering a compound given by general formula (1): [wherein T represents oxygen or sulfur atom, and Y represents alkyl, cycloalkyl, cycloalkylalkyl, phenyl, substituted phenyl, aralkyl, substituted aralkyl, heteroaryl or substituted heteroaryl group; ring W represents benzene, a 5-10 membered cycloalkene or a 5-10 membered cycloalkane ring; R1 and R2 represent independently hydrogen atom, lower alkyl group, halogen atom, cyano, trifluoromethyl, nitro, amino, substituted amino, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl group; R3 represents hydrogen atom, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, aralkyl or substituted aralkyl group;Z represents a group given by formula (1a) or (1b): {wherein A1 and A2 represent independently hydrogen atom, alkyl, substituted alkyl, cycloalkyl, saturated heterocyclic, cycloalkylalkyl, cycloalkenylalkyl, aralkyl, substituted aralkyl, heteroarylalkyl, substituted heteroarylalkyl or â€”CH2R4 group (wherein R4 represents alkenyl or alkynyl group), or A1 and A2 are combined together and form heterocyclic ring; G represents straight chain alkylene having 1-6 of the carbon number, branched alkylene having 2-8 of the carbon number, a group given by formula: (wherein p and m represent independently 0, 1 or 2 and D represents cycloalkane ring)} or {wherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A3 represents hydrogen atom, alkyl, substituted alkyl, cycloalkyl, saturated heterocyclic, cycloalkylalkyl, cycloalkenylalkyl, aralkyl, substituted aralkyl, heteroarylalkyl, substituted heteroarylalkyl or â€”CH2R4 group (wherein R4 represents alkenyl or alkynyl group), or forms bicyclo ring together with ring E}], or pharmaceutically acceptable salt to a subject in need thereof.