Patent ID: 8591951
Filing Date: 2013-11-26
Classification: A61K,A61P,B82Y,C08G,C12N

Abstract:
1. A composition comprising (a) vesicular nano spheres of a triblock oligomer consisting of a single A-B-A structure wherein each A end block is a poly(alkylene oxide) having the structure: and the B middle block is hydrophobic with the same or different repeating units having the structure according to Formula II: wherein X is Z is an integer, between 2 and about 100, inclusive, that provides a middle block with a weight-average molecular weight between about 1000 and about 25,000 g/mol; R 1 is CH═CH or (CH 2 ) n wherein n is from 0 to 18, inclusive; R 2 is selected from the group consisting of hydrogen and straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms; and R is selected from the group consisting of a bond or straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms; and (b) a hydrophobic compound complexed by said nanospheres; wherein m for each A is independently selected to provide a molecular weight for each A between about 1000 and about 15,000 g/mol; R wherein said triblock oligomer is fully resorbable and degrades by hydrolysis in vivo into biocompatible and non-cytotoxic degradation products.