Patent ID: 6809107
Filing Date: 2004-10-26
Classification: A61P,C07D

Abstract:
A compound having the structure or a pharmaceutically acceptable salt thereof, wherein(a) R1 is selected from the group consisting of H, COCOR2, COOR3 and SO2R3, (i) R2 being selected from the group consisting of C1-6 straight or branched alkyl, C1-6 straight or branched alkenyl, C5-7 cycloalkyl, 2-thienyl, 3-thienyl or phenyl, the phenyl having one to three substituents independently selected from the group consisting of H, lower alkyl, lower alkoxyl, hydroxyl and halogen, and (ii) R3 being phenylalkyl, wherein the phenyl has one to three substituents independently selected from the group consisting of H, lower alkyl, lower alkoxyl, hydroxyl and halogen; (b) â€ƒis either a saturated five-membered nitrogen containing heterocyclic ring, said ring containing one nitrogen atom, or a benzo-fused saturated six-membered nitrogen containing heterocyclic ring; (c) â€ƒis an oxazole, an oxadiazole or a thiazole; and (d) A is attached to a carbon of the five-membered heteroaromatic ring and is selected from the group consisting of COO(CH2)mAr, â€ƒ(such R1 being the same as or different than the R1 described in part (a)), CONR4(CH2)mAr, and (CH2)mO(CH2)nAr (wherein R1 cannot be COCOR2 or SO2R3), (i) R4 being H or C1-4 alkyl; (ii) Ar being selected from the group consisting of 2-pyridyl, 3-pyridyl, and 4 pyridyl; (iii) m being 1-4; and (iv) n being 0-4.