Patent ID: 6794376
Filing Date: 2004-09-21
Classification: A61K

Abstract:
A method of enhancing diffusion of a therapeutic agent through a mammalian tissue, comprising:delivering said therapeutic agent to said tissue; delivering a permeabilizer to the tissue; and using a device to elevate the temperature of the tissue to above normal body temperature; wherein the permeabilizer is of the structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or &boxH;Nâ€”â€”R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, and each of R, R1, R1, R2, R3, R4, R5 and R6 is independently hydrogen or an alkyl group having from 1 to 6 carbon atoms which may be straight chained or branched provided that only one of R1 to R6 can be an alkyl group, with the proviso that when p, q and r have a value of 0 and Y is oxygen, m+n is at least 11, and with the further proviso that when X is an imino group, q is equal to 1, Y is oxygen, and p and r are O, then m+n is at least 11.