Patent ID: 7786083
Filing Date: 2010-08-31
Classification: A61K,A61P,C07K

Abstract:
1. A compound selected from the group consisting of: Ac-D-Tyr-Hyp-Asn-Thr-Cha-Gly-Ala(cPr)-Arg(Me)-Trp-NH Ac-D-Tyr-Hyp-Asn-Thr-Cha-Glyψ((E)CH═CH)Leu-Arg(Me)-Trp-NH Ac-D-Tyr-Hyp-Alb-Thr-Cha-Glyψ((E)CH═CH)Leu-Arg(Me)-Trp-NH Ac-D-Tyr-Hyp-Asn-Thr-Cha-Glyψ((E)CH═CH)Leu-Arg-Trp-NH Ac-D-Tyr-Hyp-Alb-Thr-Cha-Glyψ((E)CH═CH)Leu-Arg-Trp-NH Ac-D-Tyr-Hyp-Alb-Thr-Cha-Gly-Ala(cPr)-Arg(Me)-Trp-NH Ac-D-Tyr-Pro(4F)-Asn-Thr-Cha-Gly-Ala(cPr)-Arg(Me)-Trp-NH or a salt thereof, wherein Hyp is trans-4-hydroxyproline, Cha is cyclohexylalanine, Ala(cPr) is cyclopropylalanine, Arg(Me) is N Glyψ((E)CH═CH)Leu is Gly-Leu wherein the CONH between Gly and Leu is substituted with (E) type alkene, Alb is 2-amino-3-ureidopropionic acid, and Pro(4F) is trans-4-fluoroproline.