Patent ID: 8236803
Filing Date: 2012-08-07
Classification: A61K,A61P,C07D

Abstract:
1. A compound selected from the group consisting of (racemic)-3-[6-(4-fluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (3R,4S)-3-[6-phenyl-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.1]heptane, (3S,4R)-3-[6-phenyl-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.1]heptane, (R)-3-[6-(4-chloro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-chloro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (racemic)-3-[6-(2-methoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-trifluoromethyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-fluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-chloro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-fluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-fluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3,4-dichloro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-trifluoromethyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3,5-dichloro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(1-isobenzofuranyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-fluoro-4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4,5-dimethyl-2-fluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-ethyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-fluoro-5-trifluoromethyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3,4OCH2O-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-methoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-fluoro-4-methoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-difluoromethoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-methoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-isopropyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3,4-dimethyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2,5-difluoro-4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-fluoro-5-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(3-trifluoromethoxy-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (3R,4S)-3-[6-(2-fluoro-4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.1]heptane, (3S,4R)-3-[6-(2-fluoro-4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.1]heptane, (R)-3-[6-(2,5-difluoro-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(4-n-propyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-chloro-4-methyl-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(indan-5-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(6-tetralinyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-naphthyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, (R)-3-[6-(2-benzothienyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane, and (R)-3-[6-(1-naphthyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane; in free base or acid addition salt form.