Patent ID: 8697644
Filing Date: 2014-04-15
Classification: A61K,A61P

Abstract:
1. A method of making a stable solution for parenteral injection, the method comprising: (a) drying a mixture comprising glucagon or a salt thereof in a non-volatile buffer to a dried glucagon powder, wherein the dried glucagon powder has a pH memory of from about 2 to 3; and (b) reconstituting from about 0.1 mg/mL up to the solubility limit of the dried glucagon powder in an aprotic polar solvent to obtain a solution, wherein the dried glucagon powder is solubilized in the aprotic polar solvent, wherein the aprotic polar solvent is dimethylsulfoxide (DMSO) or n-methyl pyrrolidone (NMP), or a mixture thereof, wherein the water content of the solution is less than 5%, and wherein the dried glucagon powder maintains the pH memory when the dried glucagon powder is reconstituted in the aprotic polar solvent.