Patent ID: 6667301
Filing Date: 2003-12-23
Classification: A61K,A61P,C07D

Abstract:
A compound of Formula I wherein:R1, R2 and R3 are independently in each occurrence hydrogen, halogen, (C1-6)-alkyl, â€”ORâ€², â€”SRâ€², â€”NRâ€²Râ€³, â€”SORâ€², â€”SO2Râ€², â€”COORâ€², â€”OCORâ€², â€”OCONRâ€²Râ€³, â€”OSO2Râ€², â€”OSO2NRâ€²Râ€³; â€”NRâ€²SO2Râ€³, â€”NRâ€²CORâ€³, â€”SO2NRâ€²Râ€³, â€”SO2(CH2)1-3CONRâ€²Râ€³, â€”CONRâ€²Râ€³, cyano, haloalkyl, or nitro; or R1 and R2 if adjacent, taken together with the carbons to which they are attached may also form a 5- to 7-membered aromatic, saturated or unsaturated ring, optionally incorporating one or two ring heteroatoms chosen from N, S (O)0-2, or O, and optionally substituted with (C1-6)-alkyl, halo, cyano or lower alkoxy; Râ€² and Râ€³ are independently in each occurrence hydrogen, (C1-6)-alkyl, substituted lower alkyl, (C0-3)alkylalkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C1-3)-alkyl, heteroaryl-(C1-3)-alkyl, heterocyclyl-(C1-3)-alkyl, cycloalkylalkyl, cycloalkyl, or Râ€² and Râ€³ together with the nitrogen they are attached may also form a 5- to 7-membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O)0-2; R4 is independently in each occurrence (C1-6) alkyl; R5 is independently in each occurrence (C1-6) alkyl, (C1-6) alkenyl, (C1-6) alkynyl, or cycloalkyl; one of X, Y or Z is independently S, O, or Nâ€”R6, the others are CH2; R6 is hydrogen, (C1-6)-alkyl, haloalkyl, aryl(C1-6)alkyl, heteroaryl(C1-6)alkyl, â€”(C1-6)â€”CRâ€²Râ€²Râ€², â€”COORâ€², â€”SO2Râ€², â€”C(O)Râ€², â€”SO2(CH2)0-3NRâ€²Râ€³, â€”CONRâ€²Râ€³, â€”C(O)OCH2OC(O)Râ€², â€”C(O)OCH2SC(O)Râ€², or â€”PO(ORâ€²)2, where Râ€² and Râ€³ are as defined above; m is 2; n is an integer from 1 to 6 inclusive; or a pharmaceutically acceptable salt or solvate thereof.