Patent ID: 7344872
Filing Date: 2008-03-18
Classification: A61K,A61P,C07K,C12N

Abstract:
1. A recombinant virus comprising an adenovirus capsid, which capsid comprises one or more fragments of the C68 hexon protein having the amino acid sequence of SEQ ID NO: 16 fused to a heterologous adenovirus hexon peptide, said capsid encapsidating a molecule for delivery to a target cell, wherein the molecule comprises an adenovirus 5′ inverted terminal repeat sequence (ITRs), a minigene, and an adenovirus 3′ ITR, wherein said one or more fragments of the C68 hexon protein consists of an amino acid sequence selected from the group consisting of: (a) amino acids 125 to 443 of SEQ ID NO:16; (b) amino acids 131 to 441 of SEQ ID NO:16; (c) amino acids 138 to 44l of SEQ ID NO:16; (d) amino acids 138 to 163 of SEQ ID NO:16; (e) amino acids 170 to 176 of SEQ ID NO:16; (f) amino acids 195 to 203 of SEQ ID NO:16; (g) amino acids 233 to 246 of SEQ ID NO:16; (h) amino acids 253 to 264 of SEQ ID NO:16; (i) amino acids 287 to 297 of SEQ ID NO:16; and (j) amino acids 404 to 430 of SEQ ID NO:16.