Patent ID: 7531553
Filing Date: 2009-05-12
Classification: A61P,C07D

Abstract:
1. A compound of Formula I wherein W is NR 4 ; X is O; wherein Y 1 is N, Y 2 is O, dashed line “a” is absent and dashed line “b” indicates a bond; wherein ring A is phenyl; wherein R is selected from a) substituted or unsubstituted 6-10 membered aryl, or b) substituted or unsubstituted cycloalkyl wherein R 1 is substituted or unsubstituted quinolinyl, wherein R 2 is optionally substituted cycloalkyl, optionally substituted phenyl, cyano, alkylaminoalkoxy, alkylaminoalkoxyalkoxy, nitro, lower alkyl substituted with R 5 , lower alkenyl substituted with R 5 , and lower alkynyl substituted with R 5 ; wherein R 3 is independently selected from H, lower alkyl, lower aminoalkyl, lower alkylaminoalkyl, optionally substituted phenyl, optionally substituted 3-6 membered heterocyclyl, optionally substituted C 3 -C 6 -cycloalkyl, optionally substituted phenylalkyl, optionally substituted 3-6 membered heterocyclylalkyl, optionally substituted C 3 -C 6 cycloalkylalkyl, and lower haloalkyl; wherein R 4 is independently selected from H, and lower alkyl; and wherein R 5 is one or more substituents independently selected from H, halo, optionally substituted cycloalkyl, optionally substituted phenyl, cyano, alkylaminoalkoxy, and nitro; and enantiomers, diastereomers, pharmaceutically acceptable salts and solvates thereof.