Patent ID: 9197859
Filing Date: 2015-11-24
Classification: H04N

Abstract:
1. A device for counting rare discrete moieties in a large surface area sample chamber, the device comprising: (a) a sample holder for receiving and containing a non-flowing opaque fluid sample, said holder having walls arranged to create a volumetric chamber with at least one facial surface of a predetermined chamber length and width, and a surface area of at least 1 cm (b) a light source for producing a beam of illuminating light impinging upon the chamber to illuminate the sample in the chamber in its entirety, said sample including at the time of illumination suspended complexes of rare discrete moieties and an optically-active cell-targeting agent, and said beam having a wavelength selected so as to be disposed to interact at least in part with said optically active agent and to produce a modified light in addition to the illuminating light as a result of said interaction; (c) an imaging light detector arranged to detect said modified light, and for providing a detected image; and, (d) image analysis hardware, software or both for determining the presence, absence, count, or concentration of said cells or discrete moieties based upon said detected image.