Patent ID: 7262327
Filing Date: 2007-08-28
Classification: C07C

Abstract:
1. A recycling process for preparing sertraline (1S, 4S) comprising: a) providing a mixture containing sertralone, mandelic acid, and sertraline distereoisomers (1S, 4R), (1S, 4S), (1R, 4R) and (1R, 4S); b) removing sertralone from the mixture; c) removing mandelic acid from the mixture; d) isomerizing the mixture to increase the 4S to 4R ratio; e) oxidizing the isomerized mixture to obtain an imine or a ketone at the C f) reducing the imine to a mixture of 4 stereoisomers, or transforming the ketone to the imine and then reducing the imine to a mixture of the 4 stereoisomers; g) recovering sertraline from the mixture; and h) optionally repeating steps (a) to (g), or steps (d) to (g).