Patent ID: 6046188
Filing Date: 2000-04-04
Classification: A61K,A61P,A61Q,C07C,C07F

Abstract:
A method for treating inflammation in a mammal, said method comprising administering to said mammal a therapeutically effective amount of a salen-metal complex of the formula: ##STR16## wherein: M is selected from the group consisting of Mn, Co, Fe, V, Cr, and Ni;A is an anion;n is either 0, 1, or 2;X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are independently selected from the group consisting of hydrogen, silyls, aryls, arylalkyls, primary alkyls, secondary alkyls, tertiary alkyls, alkoxys, aryloxys, aminos, quaternary amines, heteroatoms, and hydrogen;Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Y.sub.5, and Y.sub.6 are independently selected from the group consisting of hydrogen, halides, alkyls, aryls, arylalkyls, silyl groups, aminos, alkyls or aryls bearing heteroatoms, alkoxys, and halide; andR.sub.1, R.sub.2 R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, aryl, fatty acid esters, substituted alkoxyaryls, heteroatom-bearing aromatic groups, arylalkyls, primary alkyls, secondary alkyls, and tertiary alkyls.