Patent ID: 6013626
Filing Date: 2000-01-11
Classification: A61P,C07D,Y10S

Abstract:
A cryptophycin represented by the structure: ##STR47## wherein: Ar is phenyl or any unsubstituted or substituted aromatic or heteroaromatic group;R.sub.1 is a halogen, SH, amino, monoalkylamino, dialkylamino, trialkylammonium, alkythio, dialkysulfonium, sulfate, or phosphate;R.sub.2 is OH or SH; orR.sub.1 and R.sub.2 may be taken together to form an epoxide ring, an aziridene ring, an episulfide ring, a sulfate ring or a monoalkylphosphate ring; orR.sub.1 and R.sub.2 may be taken together to form a second bond between C.sub.18 and C.sub.19 ;R.sub.3 is a lower alkyl group;R.sub.4 is H;R.sub.5 is H;R.sub.4 and R.sub.5 may be taken together to form a second bond between C.sub.13 and C.sub.14 ;R.sub.6 is a benzyl, hydroxybenzyl, alkoxybenzyl, halohydroxybenzyl, dihalohydroxybenzyl, haloalkoxybenzyl, or dihalohydroxybenzyl group;R.sub.7 is H or a lower alkyl group;R.sub.8 is H or a lower alkyl group;R.sub.9 is H or a lower alkyl group;R.sub.10 is H or a lower alkyl group;X is O, NH or alkylamino; andY is O, NH or alkylaminowherein the following structures are excluded: ##STR48##