Patent ID: 7769575
Filing Date: 2010-08-03
Classification: C07K,C12N,Y02A

Abstract:
1. A computer-implemented method of identifying a drug candidate compound for the treatment of an angiogenesis mediated or vascular stabilization disorder, comprising: a) providing on a computer readable storage medium X, Y, and Z atomic structure coordinates as set forth in b) generating and/or imaging a three-dimensional structure of all or a portion of the HPTP-β catalytic domain (SEQ ID NO: 7) from the X, Y, and Z coordinates of step (a); c) positioning one or more candidate compounds at one or more potential drug candidate compound binding sites of the imaged three-dimensional structure from step (b) by determining the binding mode(s) of said one or more candidate compounds with said site(s) of the imaged-three dimensional structure, wherein the binding sites are selected from the group consisting of: (a) the P(0), P(+1), and/or P(−1) binding sites, (b) amino acids 152, 74-77, 209-214, 244-253, 288-290 and 293 of SEQ ID NO: 7, (c) amino acids 48-66, 76-80, 284-292 and 212-214 of SEQ ID NO: 7, (d) amino acids 69-76, 119-123 and 149-154 of SEQ ID NO: 7, (e) d) identifying from the one or more candidate compounds those with the best fit and which may bind or modulate HPTP-β as drug candidate compounds useful for the treatment of an angiogenesis mediated or vascular stabilization disorder.