Patent ID: 6111084
Filing Date: 2000-08-29
Classification: A61K,A61P,C07H,C07K

Abstract:
A sialyl Lewis mimetic represented by the following structure: ##STR14## wherein: X is a radical selected from a group consisting of --O-- and --NH--;R.sub.4 is hydrogen or a radical selected from a group consisting of --(CH.sub.2 CH.sub.2 --O--).sub.n --(CH.sub.2).sub.m --CH.sub.3 --(C.sub.1 -C.sub.20 alkyl), -phenyl, -benzyl, -nitrobenzyl, -trityl, -allyl, -furoyl, -cinnamoyl, -thiophenesulfonyl, [--CH.sub.n CO.sub.2 --(C.sub.1 -C.sub.20 alkyl) --CH.sub.n CO.sub.2 -allyl, and --Ch.sub.n CO.sub.2 H] --(CH.sub.2).sub.n CO.sub.2 --(C.sub.1 -C.sub.20 alkyl), --(CH.sub.2).sub.n CO.sub.2 -allyl, and --(CH.sub.2).sub.n CO.sub.2 H;R.sub.10 is a radical selected from a group consisting of --CH(OH)--CH.sub.2 (OH), --CH(OBn)--CH.sub.2 --(OH), and CH(OH)--CH.sub.2 --(OBn);R.sub.11 is a radical selected from a group consisting of --(CH.sub.2).sub.p CO.sub.2 H, --(CH.sub.2).sub.p CO.sub.2 Bn, --(CH.sub.2).sub.p PO(OBn).sub.2, and --(CH.sub.2).sub.p PO(OH).sub.2 ;1.ltoreq.n.ltoreq.10;1.ltoreq.m.ltoreq.10; and1.ltoreq.p.ltoreq.5;with the following proviso:if R.sub.1 is hydrogen or --(C.sub.1 -C.sub.20 alkyl), then R.sub.11 is neither --(CH.sub.2).sub.3 CO.sub.2 H nor --(CH.sub.2).sub.3 CO.sub.2 Bn.