Patent ID: 9050321
Filing Date: 2015-06-09
Classification: A61K,C07K

Abstract:
1. An anti-αvβ6 integrin antibody obtained by inserting the amino acid sequence consisting of AVPNLRGDLQVLAQKVA (SEQ ID NO: 19) between adjacent amino acid residues Thr98 and Gly99 (in Kabat numbering) of CDR H3 of a parent antibody, wherein the parent antibody comprises the following complementarity determining regions (CDRs): (a) Heavy Chain CDR 1: Asp Ser Tyr Met His (SEQ ID NO: 53); and (b) Heavy Chain CDR 2: Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly (SEQ ID NO; 54); and (c) Heavy Chain CDR 3: (i) Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr (SEQ ID NO: 55), or (ii) Gly Thr Pro Thr Gly Pro Tyr Pro Phe Asp Tyr (SEQ ID NO: 56); and (d) Light Chain CDR 1: (i) Ser Ala Ser Ser Ser Val Pro Tyr Met His (SEQ ID NO: 57), or (ii) Ser Ala Ser Ser Ser Val Ser Tyr Met His (SEQ ID NO: 58); and (e) Light Chain CDR 2: (i) Ser Thr Ser Asn Leu Ala Ser (SEQ ID NO: 59), or (ii) Leu Thr Ser Asn Leu Ala Ser (SEQ ID NO: 60); and (f) Light Chain CDR 3: Gln Gln Arg Ser Ser Tyr Pro Leu Thr (SEQ ID NO: 61).