Patent ID: 7256005
Filing Date: 2007-08-14
Classification: A61K

Abstract:
1. A method of screening for an inhibitor of HCV p7 protein, comprising: (a) incorporating a full-length HCV p7 protein into a membrane to create an HCV p7-containing membrane, wherein the HCV p7-containing membrane has an increased permeability relative to a membrane that does not contain HCV p7 protein; (b) contacting the HCV p7 protein with a test compound; (c) comparing the permeability of the HCV p7-containing membrane, wherein the HCV p7 protein has been contacted with a test compound, to the permeability of a HCV p7-containing membrane, wherein the HCV p7 protein has not been contacted with the test compound; and (d) observing a decrease in the permeability in the HCV p7-containing membrane, thereby identifying the inhibitor of HCV p7 protein.