Patent ID: 8304425
Filing Date: 2012-11-06
Classification: A61P,C07D

Abstract:
1. A compound of formula I, II, III, or IV, or pharmaceutically acceptable salts thereof: wherein: R1, R2, and R3 are independently selected from the group consisting of H, F, Cl, Br, I, —NR7R8, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —O—(C3-C9) cycloalkyl, and —O—(C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; R4 is selected from the group consisting of H, —(C1-C4) alkyl, and —(C1-C4) substituted alkyl; R5 is selected from the group consisting of H, —(C1-C6) alkyl, —CH R6 is selected from the group consisting of —O—P(═O)(OH) R7 and R8 are independently selected from the group consisting of H and —(C1-C6) alkyl; R9, R10, and R11 are independently selected from the group consisting of H, NHR12, —(C1-C6)alkyl, —(C1-C6) substituted alkyl, —(C3-C9)cycloalkyl, —(C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; Q is selected from the group consisting of indolyl, substituted indolyl, aryl, heteroaryl, heterocyclyl, and alkyl; V and Z are independently selected from the group consisting of O, S, H X is selected from the group consisting of —CH R12 is selected from the group consisting of H, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —C(═O)—O—(C1-C6) alkyl, and —C(═O)—O—(C1-C6) substituted alkyl; W is selected from the group consisting of —CH m is 0, 1 or 2.