Patent ID: 6589986
Filing Date: 2003-07-08
Classification: A61K,A61P,Y10S

Abstract:
A method of treatment or inhibition of anxiety disorders in a mammal, the method comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of the formula: wherein: R1 is selected from hydrogen, C1-C6-alkyl, C2-C6-alkanoyl or the radical Ar; R2 is selected from hydrogen or C1-C6-alkyl; R3 is selected from C1-C6-alkoxy, NH2, C1-C6-alkylamino, C1-C6-dialkylamino, amino substituted by the radical Ar, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, the radical Ar or the radical ArOâ€”; R4 is selected from hydrogen, C1-C6-alkyl or the radical Ar; R5 is selected from hydrogen or C1-C6-alkyl or the radical Ar; Alk is a straight or branched alkylene group with 1-9 carbon atoms, which can also be substituted by the radical Ar; Ar is a phenyl radical substituted by the radicals R6, R7 and/or R8 where these radicals R6, R7 and R8 are the same or different and represent C1-C6-alkyl, C3-C7-cycloalkyl, hydroxy, C1-C6-alkoxy, C2-C6-alkanoyloxy, halogen, hydroxy, C1-C6-halogenoalkyl, â€”CN, â€”NH2, â€”NHâ€”C1-C6-alkyl, â€”N(C1-C6-alkyl)2, â€”CO2H, â€”COâ€”C1-C6-alkyl, â€”COâ€”Oâ€”C1-C6-alkyl, â€”COAr, â€”COâ€”OAr, â€”CONH2, â€”CONHâ€”C1-C6-alkyl â€”CON(C1-C6-alkyl)2, â€”CONHAr, â€”NHâ€”COâ€”C1-C6-alkyl, â€”NHCOâ€”Ar, â€”NHCOâ€”C1-C6-alkoxy, â€”Nâ€”Hâ€”COâ€”Ar, â€”NHCOâ€”NH2, â€”NHCOâ€”N(â€”C1-C6-alkyl)2, â€”NHCOâ€”NHAr, â€”NHâ€”SO2â€”Câ€”1C6-alkyl, â€”NHâ€”SO2Ar, â€”NHâ€”SO2-nitrophenyl, â€”SO2â€”OH, â€”SO2â€”C1-C6-alkyl, â€”SO2â€”Ar, â€”SO2â€”C1-C6-alkoxy, â€”SO2â€”OAr, â€”SO2â€”NH2, â€”SO2â€”NHâ€”C1-C6-alkyl, â€”SO2â€”N(C1-C6-alkyl)2, â€”SO2â€”NHAr, or â€”SO2â€”C1-C6-alkoxy; and n is 0 or 1; or a pharmaceutically acceptable salt thereof.