Patent ID: 8680047
Filing Date: 2014-03-25
Classification: A61K,A61P,C07K

Abstract:
1. A method of treating a FAS-related pathology comprising administering to a mammal suffering from said FAS-related pathology a therapeutically effective amount of a Fas mimetic represented by the formula (I) wherein B1 and B9 are independently a peptide of 1-6 genetically encoded amino acids, at least one of which is a genetically encoded hydrophobic amino acid, or a genetically encoded aromatic amino acid, Z Z X X X X X “—” is a covalent linkage comprising an amide or a substituted amide thereof, and “═” is a covalent linkage, or a pharmaceutically acceptable salt thereof, wherein said FAS-related pathology is selected from the group consisting of rheumatoid arthritis, Sjogren's syndrome, multiple sclerosis, hepatitis, retinal neovascularization, corneal neovascularization, renal injury, graft rejection, HIV infection and macular degeneration.