Patent ID: 8449912
Filing Date: 2013-05-28
Classification: A61K

Abstract:
1. A sustained release formulation for providing continuous sustained release of alfuzosin comprising: a) a first layer comprising alfuzosin or pharmaceutically acceptable salts thereof and about 0.1% to about 5% of at least one hydrophilic rate controlling polymer; b) a second layer comprising alfuzosin or pharmaceutically acceptable salts thereof and about 0.5% to about 95% of at least one hydrophilic rate controlling polymer; and c) an optional third layer comprising one or more hydrophilic rate controlling polymers, wherein about 35% or less amount of alfuzosin is released within first hour and about 50% or more amount of alfuzosin is released within next 19 hours when the dissolution is measured using USP Type II apparatus at 100 rpm and using 0.01 M hydrochloric acid at 37° C.±2° C.