Patent ID: 6031073
Filing Date: 2000-02-29
Classification: A61K,C07K

Abstract:
A cyclic polypeptide having at least one polypeptide loop, said loop comprising a thioether linkage, and said cyclic polypeptide represented by the formula (SEQ ID NO:1): ##STR4## wherein S is a sulfur atom; C is a carbon atom;N is a nitrogen atom; O is an oxygen atom;L.sup.1 and L.sup.2 are independently divalent hydrocarbyl moieties of 1 to 10 carbon atoms;R.sup.1 and R.sup.2 are independently --H or an alkyl group having 1 to 6 carbon atoms;R.sup.1 and R.sup.2 are attached to carbon atoms, C, which independently have chirality R or S;X.sup.1 is represented by the formula J.sup.N --(AA).sub.p --;X.sup.2 is represented by the formula --(AA).sub.q --;X.sup.3 is represented by the formula --(AA).sub.r --J.sup.C ;wherein AA denotes an amino acid;J.sup.N is an N-terminal substituent;J.sup.C is a C-terminal substituent;p, q, and r are independently whole numbers from 0 to 50; andwherein R.sup.N1 and R.sup.N2 are independently --H or --CH.sub.3.