Patent ID: 6747151
Filing Date: 2004-06-08
Classification: A61K,A61P,C07D

Abstract:
A compound of formula wherein Q is a single bond or â€”CR1R2; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, C1-C10 alkoxyalkyl, C1-C10 polyhydroxyalkyl, â€”(CH2)aCO2H, and â€”(CH2)bNR3R4; R3 and R4 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, C1-C10 polyhydroxyalkyl, and â€”(CH2)aCO2H; R5, R6, and R7 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, hydroxyl, â€”SO3H, C1-C10 alkoxyl, C1-C10 polyhydroxyalkyl, C1-C10 polyalkoxyalkyl, â€”(CH2)aCO2H, and â€”(CH2)bNR3R4; X is selected from the group consisting of â€”CR8R9, â€”Oâ€”, â€”NR3, â€”Sâ€”, and â€”C&boxH;O; Y is selected from the group consisting of â€”CR10R11, â€”Oâ€”, â€”NR3, â€”Sâ€”, and â€”C&boxH;O; Z is selected from the group consisting of â€”CR12R13, â€”Oâ€”, â€”NR3, â€”Sâ€”, and â€”C&boxH;O; R8 to R13 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, C1-C10 alkoxyalkyl, C1-C10 polyhydroxyalkyl, â€”(CH2)aCO2H, and â€”(CH2)bNR3R4; R5-R6, R6-R7, R8-R10, or R10-R12 together optionally form a six-membered ring; E is either a hydrogen atom or is selected from the group comprising antibodies, peptides, peptidomimetics, carbohydrates, glycomimetics, drugs, hormones, or nucleic acids; L is the linker unit â€”(CH2)câ€”, a and b independently range from 0 to 10, and c ranges from 1 to 10.