Patent ID: 7175856
Filing Date: 2007-02-13
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition in the form of an oral suspension of a normally unpalatable acidic drug, which is a quinolone-carboxylic acid derivative or a salt thereof or a naphthyridone carboxylic acid derivative or a salt thereof, which suspension is substantially devoid of bitter taste, which comprises particles of a readily soluble acidic drug which in solution has a bitter taste, and water for oral suspension, and one or more alkaline pH modifying agents mixed with the particles of drug which renders and maintains the drug in substantially insoluble form in the oral suspension, so that the bitter taste of the drug is masked without the use or need for polymer or wax coatings or microencapsulation wherein the pH modifying agents adjusts suspension pH to cause reduction in solubility or in-situ precipitation of the drug in the suspension.