Patent ID: 7057066
Filing Date: 2006-06-06
Classification: C07C,C07D,Y02P

Abstract:
1. A process for preparing a 3-amino-2-hydroxypropionic acid derivative represented by the general formula (1): wherein R converting a N-protected-3-amino-2-hydroxypropionic acid derivative having a steric configuration at 2-position carbon reverse to that of the above compound (1) and represented by the general formula (2): wherein R S S by a reaction for introducing a leaving group, into a N-protected-3-aminopropionic acid derivative represented by the general formula (3): wherein R L represents a leaving group selected from the group consisting of a sulfonyloxy group, a halosulfinyloxy group and a halogen atom; and S then converting the derivative (3), by a reaction for inverting the steric configuration at 2-position, into a substituted-3-amino-2-hydroxypropionic acid derivative having an inverted steric configuration at 2-position carbon and represented by the general formula (4): wherein R S S S S and then converting the derivative (4), by a reaction for removing substituents S