Patent ID: 6818403
Filing Date: 2004-11-16
Classification: B01J,B01L,B82Y,C40B,G01N,G06T

Abstract:
A method of monitoring haptotaxis comprising:providing a device for monitoring haptotaxis having a housing defining a chamber, the chamber including: a first well region including at least one first well, the first well region configured to receive immobilized test biomolecules therein and further including test biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region with test biomolecules immobilized therein and including at least one channel connecting the first well region and the second well region with one another. forming a surface concentration gradient along a longitudinal axis of the chamber by decreasing the concentration of test biomolecules from the at least one first well to the at least one second well; placing a first sample comprising cells in the at least one second well; and monitoring haptotaxis of the cells.