Patent ID: 8957015
Filing Date: 2015-02-17
Classification: A61K,A61P,C07K,C12Q,G01N

Abstract:
1. A method of inhibiting cellular proliferation, the method comprising: increasing the amount of p47ING3 polypeptide in a cell, wherein the p47ING3 polypeptide comprises (i) an amino acid sequence having at least 95% identity to SEQ ID NO:1 and (ii) the amino acid sequence of SEQ ID NO:9; and wherein said cell produces a wild-type p53 molecule, wherein said increasing in the amount of p47ING3 is achieved by a method selected from the group consisting of transducing said cell with a p47ING3 expression cassette, activating the promoter of the endogenous p47ING3 gene in said cell with a DNA activation sequence, and microinjecting p47ING3 polypeptide into said cell.