Patent ID: 6235309
Filing Date: 2001-05-22
Classification: A61K,Y10S

Abstract:
A composition for inhibiting the binding between a first cell having a receptor comprising selectin and a second cell having a ligand for said receptor, comprising one or more lipid assemblies, wherein said one or more lipid assembies comprise:a) lipid monomers wherein substantially all of said lipid monomers are unpolmerized;b) one or more surface exposed negatively charged oxyacid groups attached to said one or more lipid assemblies and, wherein said oxyacid groups are selected from the group consisting of carboxyl groups and groups of the form (XO.sub.n)(O.sup.-).sub.p, wherein n+p>2 and X is an atom capable of binding three or more oxygen atoms, wherein said one or more surface exposed negatively charged oxyacid groups meets the anionic binding requirement of said receptor; andc) one or more surface exposed carbohydrates which selectively binds to said receptor.