Patent ID: 8067025
Filing Date: 2011-11-29
Classification: A61K,A61L,A61P

Abstract:
1. A medical device comprising a polymer and a metal complex, the metal complex comprising a metal and at least one ligand, wherein the polymer forms the medical device or a coating of the medical device; wherein the at least one ligand of the metal complex covalently attaches to a surface of the medical device or the coating on the medical device via a spacer, wherein the spacer is a phenyl group, an aryl group, a short chain peptide, biocompatible oligomer, or biocompatible polymer functionalized by a reactive group selected from carboxyl, hydroxyl, thiol, amine, acid halide, N-hydroxysuccinimide, acryloyl, and vinyl sulfone, and wherein the polymer is a copolymer of monomers selected from 2-hydroxyethyl methacrylate (HEMA), hydroxypropyl methacrylate (HPMA), hydroxypropylmethacrylamide, PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethylphosphorylcholine (MPC), methacrylic acid (MA), and acrylic acid (AA); wherein the metal complex catalyzes the generation of nitric oxide in the blood stream or a tissue adjacent to the medical device wherein the medical device is a bioabsorbable polymer stent.