Patent ID: 9193703
Filing Date: 2015-11-24
Classification: A61P,C07D

Abstract:
1. A process for preparing N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutically acceptable salts thereof, comprising reacting a salt of (5-amino-2-butyl-1-benzofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II) where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), and n is 1 if A is dibasic acid, and n is 1 or 2 if A is a monobasic acid, with a mesylating reagent in a heterogeneous reaction, optionally, in the presence of a phase transfer catalyst.