Patent ID: 8236766
Filing Date: 2012-08-07
Classification: A61P,C07K

Abstract:
1. A method of prophylaxis or treatment of a kappa opioid receptor-associated disease or condition selected from the group consisting of pain, pancreatitis and pruritis, in a mammal, the method comprising administering to the mammal a composition comprising an effective amount of a synthetic peptide amide having the formula: or a stereoisomer, mixture of stereoisomers, pharmaceutically acceptable salt, hydrate, acid salt hydrate, or N-oxide thereof, wherein Xaa Xaa Xaa Xaa wherein G is is an optionally substituted 4 to 8-membered heterocyclic ring moiety wherein Y is C or N and Z is C, N, O, S, SO, or SO wherein W is selected from the group consisting of: wherein V is C wherein (a) R (b) R (c) R (d) R wherein each of said optionally substituted 4-, 5-, 6-, 7-, 8-, and 9-membered heterocyclic ring moieties comprising R provided that when the Y and Z-containing ring moiety is a six or seven membered ring comprising a single ring heteroatom and wherein such heteroatom is N, and e is zero, then R provided further that when the Y and Z-containing ring moiety is a six membered ring comprising two ring heteroatoms, both Y and Z are N, W is null, and -V lastly, provided that if the Y and Z-containing ring moiety is a six membered ring comprising an S or O ring heteroatom, or if the Y and Z-containing ring moiety is a six membered ring comprising two ring heteroatoms, wherein both Y and Z are N and W is null, or if the Y and Z-containing ring moiety is a six membered aromatic ring comprising a single ring heteroatom, which heteroatom is N, then, when e is zero, R