Patent ID: 7846969
Filing Date: 2010-12-07
Classification: A61K,A61P,A61Q

Abstract:
1. A process for production of a ceramide emulsion comprising: adding (C) one or more ceramides to (A) one or more sphingosines, and then adding (B) an acidic compound and water thereby forming one or more sphingosine salts; wherein said one or more sphingosine salts emulsify said (C) one or more ceramides thereby forming said ceramide emulsion; said (A) one or more sphingosines being represented by Formula (1): wherein R 1 represents a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group, a carbonyl group or an amino group; Y represents a methylene group, a methine group or an oxygen atom; X 1 , X 2 and X 3 each represent independently a hydrogen atom, a hydroxyl group or an acetoxy group, and X 4 represents a hydrogen atom, an acetyl group or a glyceryl group or, together with an adjacent oxygen atom, forms an oxo group, wherein when Y is a methine group, either one of X 1 and X 2 is a hydrogen atom, and the other is not present, and when X 4 forms an oxo group, X 3 is not present; R 2 and R 3 each represent independently a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; groups “R”s each are independently a hydrogen atom or an amidino group or each represent independently a linear or branched, saturated or unsaturated hydrocarbon group having in total 1 to 8 carbon atoms which optionally have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group; “a” represents a number of 2 or 3; and a bond represented by a “broken line and solid line” represents a single bond or a double bond; said (B) acidic compound being selected from inorganic acids and organic acids having a molecular weight of 200 or less; and said (C) one or more ceramides being represented by Formula (2): wherein R 7 represents a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group, a carbonyl group or an amino group; Z represents a methylene group, a methine group or an oxygen atom; X 5 , X 6 and X 7 each represent independently a hydrogen atom, a hydroxyl group or an acetoxy group, and X 4 represents a hydrogen atom, an acetyl group or a glyceryl group or, together with an adjacent oxygen atom, forms an oxo group, wherein when Z is a methine group, one of X 5 and X 6 is a hydrogen atom, and the other is not present, and when X 4 forms an oxo group, X 7 is not present; R 8 and R 9 each represent independently a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; R 10 represents a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 5 to 60 carbon atoms which is optionally substituted with a hydroxyl group, a carbonyl group or an amino group and which optionally have an ether bond, an ester bond or an amide bond in a principal chain; R 11 represents a hydrogen atom or a linear or branched, saturated or unsaturated hydrocarbon group having in total 1 to 8 carbon atoms which optionally have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group; and a bond represented by a “broken line and solid line” represents a single bond or a double bond.