Patent ID: 6451828
Filing Date: 2002-09-17
Classification: A61K

Abstract:
A method of selectively inhibiting glutaminase in a cell or tissue, comprising administering to said cell or tissue an effective amount of a compound of formula I: whereX is sulfur or oxygen, and R1 and R2 are independently selected from the group consisting of lower alkyl, lower alkoxy, aryl, thiophenyl and â€”(CH2 )n-aryl, where n is 0 or 1, and aryl is a monocyclic aromatic or heteroaromatic group, having ring atoms selected from the group consisting of carbon, nitrogen, oxygen, and sulfur, and having at most three non-carbon ring atoms, which group may be unsubstituted or substituted with one or more substituents selected from halogen, lower alkyl, lower alkoxy, amino, lower alkyl amino, amino(lower alkyl), or halo(lower alkyl).