Patent ID: 6358973
Filing Date: 2002-03-19
Classification: A61P,C07D

Abstract:
A compound of formula I: whereinA is a 6-membered unsaturated or saturated heterocycle containing a nitrogen atom that may be optionally substituted by an oxo group (&boxH;O); R is: hydrogen, (C4-7)cycloalkyl, aryl selected from phenyl, napthyl or indanyl; (C1-8)alkyl optionally branched and/or substituted by (C4-7) cycloalkyl or aryl selected from phenyl, naphthyl or indanyl; Y is methylene or ethylene; W is a heterocycle optionally substituted by a halogen, (C1-4)alkyl, hydroxy, nitro or carboxy; R1 is: hydrogen, (C4-7)cycloalkyl or a (C2-8)alkyl optionally substituted by (C4-7)cycloalkyl or aryl selected from phenyl, naphthyl or indanyl, or a heterocycle selected from the group consisting of pyrrole, imidazole, pyrazole, pyridine, pyrazine, pyrimidine, pyridazine, piperazine, triazine, morpholine, pyrrolidine, pyrroline, imidazoline, pyrazoline, pyrazolidine, imidazolidine, piperidine, furan, pyran, isothiazole, isoxazole, and thiophene, wherein R1 may be optionally interrupted by one or more heteroatoms or heterogroups; R2 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; and the Nâ†’O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof; provided that when Y is methylene and R is hydrogen, R1 is not hydrogen.