Patent ID: 6096788
Filing Date: 2000-08-01
Classification: A61K,Y02A

Abstract:
A pharmaceutical composition composed of a physiologically acceptable excipient and, as the active substance, a compound comprising the following general formula (1): ##STR4## wherein: R1 designates a hydrocarbon group with 1 to 20 carbon atoms, andR2 and R3 are identical or different and independently designate a hydrocarbon group with 1 to 20 carbon atoms having methyl or ethyl substitution groups, or halogen substitution groups wherein said halogen substitution groups are selected from chlorine, bromine and iodine, or trifluoromethyl, trifluoroethyl or trifluoropropyl substitution groups,where R1 is different from an ethyl group, R2 and R3 are not simultaneously methyl groups, orR1 designates a hydroxylalkyl group composed of 1 to 5 carbon atoms, where the hydroxyl groups are etherified by a methyl, ethyl group substitution of the hydrogen atom or substituted with silicyl derivatives of --Si(CH.sub.3).sub.3, andR2 and R3 are identical or different and designate a saturated hydrocarbon which is substituted with halogen groups wherein said halogen substitution groups are selected from chlorine, bromine and iodine, or with trifluoromethyl, trifluoroethyl or trifluoropropyl groups, orR1 designates a mono-or polyunsaturated hydrocarbon with 1 to 6 carbon atoms, andR2 and R3 are identical or different and designate a straight- or branched-chain alkyl group composed of 1 to 20 hydrocarbon units having methyl or ethyl substitution groups, or halogen substitution groups wherein said halogen substitution groups are selected from chlorine, bromine and iodine, or trifluoromethyl, trifluoroethyl or trifluoropropyl substitution groups, orR1 designates a hydrocarbon with 1 to 20 carbon atoms, andR2 and R3 form, together with nitrogen, a saturated heterogeneous cycle composed of 4 to 5 carbon atoms where one of the carbon atoms is replaced by a silicium atom, an oxygen atom or a sulfur atom, this cycle having an alkyl substitution with 1 to 3 carbon atoms which are hydroxylated, halogenated, or silicylated,where R1', R2' and R3' have the same definition as R1, R2 and R3 in the formula (1), without the restriction concerning the methyl and ethyl groups, the two polar heads being identical or not;and where X designates a hydrocarbon having an alkyl substitution with 1 to 3 carbon atoms, the hydrocarbon chain having 12 to 26 carbon atoms, excluding the following compounds:(CH.sub.3).sub.3 --N.sup.4 --(CH.sub.2).sub.16 --N.sup.4 --(CH.sub.3).sub.3 2Br.sup.-(HOCH.sub.2 CH.sub.2)(CH.sub.3).sub.2 --N.sup.4 --(CH.sub.2).sub.18 --N.sup.4 --(CH.sub.3).sub.2 (CH.sub.2 CH.sub.2 OH)2Br.sup.-(ROCH.sub.2 CH.sub.2)(CH.sub.3 CH.sub.2).sub.2 --N.sup.4 --(CH.sub.2).sub.18 --N.sup.4 --(CH.sub.2 CH.sub.3).sub.2 (CH.sub.2 CH.sub.2 OH)2Br.sup.- ##STR5##