Patent ID: 6537527
Filing Date: 2003-03-25
Classification: A61K,A61Q,C07C,C07D,Y02P,Y10S

Abstract:
A skin lightening composition comprising:a) a skin lightening active having the structure: wherein(i) each X is halo; (ii) m is an integer from 1 to 4; (iii) each Râ€² and each Râ€³ is independently selected from the group consisting of hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH2 or SH; wherein up to two of Râ€² and Râ€³ combined are other than hydrogen; (iv) each R is, independently, selected from the group consisting of hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; (v) n is an integer from 1 to 5, wherein (CRâ€²Râ€²) adjacent to Z has other than amino, SH, CN or hydroxy as Râ€²; (vi) Z is O; and (vii) any carbon, when disubstituted, having as one substituent selected from the group consisting of hydroxy, amino, cyano and tiol, has the other substituent selected from the group consisting of hydrogen, C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl, whether this substituent is Râ€² or Râ€³; in an amount effective to lighten skin; andb) a pharmaceutically-acceptable carrier therefor.