Patent ID: 6713043
Filing Date: 2004-03-30
Classification: A61K,Y02A

Abstract:
A method of inhibiting activity of enoyl reductase enzyme in a cell which comprises contacting the cell with a compound consisting of the structure set forth below, or a pharmaceutically acceptable salt or ester thereof, which compound is in an amount effective to inhibit the activity of the enzyme: wherein each of R1, R2, R3, R4, R5 and R6 is independently selected from the group consisting of H, F, Cl, Br, I, â€”OH, â€”OR7, â€”CN, â€”COR7, â€”SR7, â€”N(R7)2, â€”NR7COR8, â€”NO2, â€”(CH2)pOR7, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl; wherein each of R7 and R8 is independently selected from the group consisting of H, F, Cl, Br, I, â€”OH, â€”CN, â€”COH, â€”SH2, â€”NH2, â€”NHCOH, â€”(CH2)pOH, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl; wherein A is selected from the group consisting of â€”N2â€”, â€”NHâ€”, â€”CH&boxH;C&boxH;CHâ€”, â€”Câ‰¡Câ€”CHOHâ€”, â€”Câ‰¡Câ€”CH2â€”, â€”CH2â€”CH2â€”Oâ€”, â€”CH2â€”CH2â€”CH2â€”Oâ€”, â€”Sâ€”, â€”S(&boxH;O)2â€”, â€”C(&boxH;O)â€”, â€”C(&boxH;O)â€”Oâ€”, â€”NHâ€”C(&boxH;O)â€”, and â€”C (&boxH;O)â€”NHâ€”; and wherein each of Q and p are independently an integer from 1 to 10, and if Q is 1, A is selected from the group consisting of a (C1-C10)-alkyl chain, a (C2-C10)-alkenyl chain, a (C2-C10)-alkylene chain or a (C2-C10)-alkynyl chain which is branched or unbranched, substituted or unsubstituted and is optionally interrupted 1 to 3 times by â€”Oâ€” or â€”Sâ€” or â€”Nâ€”.