Patent ID: 8741921
Filing Date: 2014-06-03
Classification: A61P,B65D,C07D

Abstract:
1. A method of treating a disorder associated with the alpha 2 adrenergic receptor agonism, wherein the disorder is a retinal disease selected from: glaucoma, elevated intraocular pressure, optic neuropathy, corneal pain, ischemic neuropathies, diabetic retinopathy, retinal degenerative conditions, age related macular degeneration, wet macular degeneration, dry macular degeneration, geographic atrophy, diabetic retinopathy, diabetic macular edema, retinal vein occlusion, ocular hypertension, glaucoma, retinitis pigmentosa, neuritis secondary, and multiple sclerosis; pain selected from: visceral pain, headache pain, migraine, cancer pain, back pain, irritable bowel syndrome pain, muscle pain and pain associated with diabetic neuropathy; and stroke, drug dependence and addiction, withdrawal symptoms, obsessive-compulsive disorders, obesity, insulin resistance, diarrhea, diuresis, nasal congestion, spasticity, attention deficit disorder, psychoses, anxiety, depression, autoimmune disease, Crohn's disease, gastritis, Alzheimer's, and Parkinson's ALS, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I: wherein: R Y is CH or N; X is O, S, NR; and R is H or C