Patent ID: 7172764
Filing Date: 2007-02-06
Classification: A61K,A61P,B82Y,C12Y,Y02A

Abstract:
1. A method of treating a botulinum toxin intoxication in a mammal, the method comprising the step of administering to the mammal an effective amount of a glycosylated inactive botulinum toxin, wherein the effective amount of the glycosylated inactive botulinum toxin is an amount of glycosylated inactive botulinum toxin sufficient to compete with an active botulinum toxin for: (a) binding to a cell surface receptor, (b) translocation through an endosomal membrane, (c) binding to the cleavage site of a SNAP-25 protein, (d) binding to the cleavage of a synaptobrevin (VAMP), or (e) binding to the cleavage site of a syntaxin, wherein the glycosylated inactive thereby reducing the ability of the active