Patent ID: 8362207
Filing Date: 2013-01-29
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A fusion protein that has the formula, from N terminus to C terminus, selected from the group consisting of: A-B-C-D-E, E-D-C-B-A, A-B-D-C-E; and E-C-D-B-A, wherein: A is an IL-13Rα2 binding ligand and is IL-13 or an IL-13Rα2 binding fragment thereof; B is a cytosol localization element and is a C is a subcellular compartment localization signal element and is a nuclear localization element or a lysosomal localization element; D is present or absent and when present is a toxin; and E is present or absent and when present is an amphipathic antimicrobial peptide.