Patent ID: 9079977
Filing Date: 2015-07-14
Classification: A61K,A61P,C07K,C12Y,Y02A

Abstract:
1. A composition formulated for the delivery of a hydrophobic drug, the composition comprising an isolated trypanocidal peptide, wherein the isolated trypanocidal peptide consists of 17 to 25 amino acid residues and comprises a positively charged amino acid at position minus five relative to the C-terminus of the trypanocidal peptide, and wherein the trypanocidal peptide comprises at least seventeen consecutive amino acid residues of SEQ ID NO: 1 or a derivative of SEQ ID NO: 1, wherein a derivative of SEQ ID NO: 1 has a tryptophan substitution at position 1, 8, and/or 18, a deletion of a single leucine from the C-terminal leucine triplicate, one hydrophobic amino acid residue of SEQ ID NO: 1 exchanged for another hydrophobic amino acid, or one positively charged amino acid residue of SEQ ID NO: 1 exchanged for another positively charged amino acid and wherein the isolated trypanocidal peptide induces rigidification of the plasma membrane of a bloodstream form of a kinetoplastid protozoan of the genus