Patent ID: 7297334
Filing Date: 2007-11-20
Classification: A61K,A61P,C07K

Abstract:
1. A method for inhibiting VEGF-induced angiogenesis in a subject, comprising administering to said subject an effective amount of a humanized anti-VEGF antibody which binds human VEGF with a K d value of no more than about 1×10 −8 M, said humanized anti-VEGF antibody having a heavy chain variable domain comprising the following heavy chain complementarity determining region (CDR) amino acid sequences: CDRH1(GYX 1 FTX 2 YGMN, wherein X 1 is T or D and X 2 is N or H; SEQ ID NO:128), CDRH2 (WINTYTGEPTYAADFKR; SEQ ID NO:2) and CDRH3 (YPX 1 YYGX 2 SHWYFDV, wherein X 1 is Y or H and X 2 is S or T; SEQ ID NO:129) and a light chain variable domain comprising the following light chain CDR amino acid sequences: CDRL1 (SASQDISNYLN; SEQ ID NO:4), CDRL2 (FTSSLHS; SEQ ID NO:5) and CDRL3 (QQYSTVPWT; SEQ ID NO:6).