Patent ID: 6677359
Filing Date: 2004-01-13
Classification: A61P,C07D

Abstract:
A compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein:X is NR1; A, B and R1 are independently (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, wherein 1 or 2 hydrogen atoms in said alkyl, alkenyl or alkynyl are optionally and independently replaced with a monocyclic aromatic ring comprising 5-7 ring atoms independently selected from C, N, O, or S, and wherein 1-4 ring atoms are independently selected from N, O, or S; or R1 is independently hydrogen; wherein R3 is selected from hydrogen, (C1-C4)-straight or branched alkyl, (C3-C4)-straight or branched alkenyl or alkynyl, or (C1-C4) bridging alkyl, wherein said bridge is formed between the nitrogen atom to which said R3 is bound and any carbon atom of said alkyl, alkenyl or alkynyl to form a ring, and wherein said ring is optionally benzofused; wherein E is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in E are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, Oâ€”[(C1-C6)-straight or branched alkyl], Oâ€”[(C3-C6)-straight or branched alkenyl], (CH2)nâ€”N(R4)(R5), (CH2)nâ€”NH(R4)â€”(CH2)nâ€”Z, (CH2)nâ€”N(R4â€”(CH2)nâ€”Z)(R5â€”(CH2)nâ€”Z, (CH2)nâ€”Z, Oâ€”(CH2)nâ€”Z, (CH2)nâ€”Oâ€”Z, Sâ€”(CH2)nâ€”Z, CH&boxH;CHâ€”Z, 1,2-methylenedioxy, C(O)OH, C(O)Oâ€”[(C1-C6)-straight or branched alkyl], C(O)Oâ€”(CH2)nâ€”Z or C(O)â€”N(R4)(R5); wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S; wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z, each n is independently 0 to 4; each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S; and wherein no more than 4 ring atoms are selected from N, O or S; wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, Oâ€”(C1-C3)-straight or branched alkyl, C(O)Oâ€”[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or Nâ€”[(C1-C3)-straight or branched alkyl]2; K is selected from E, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E; wherein K is optionally substituted with up to 3 substituents selected from halogen, OH, Oâ€”(C1-C6)-alkyl, Oâ€”(CH2)n-Z, NO2, CO2H, C(O)â€”Oâ€”(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)nâ€”Z; or, G-, â€”C(O)â€”C(O)â€”; Y is oxygen, or N(R6); wherein R6 is hydrogen, E, (C1-C6)-straight or branched alkyl, (C3-C6)-straight or branched alkenyl or alkynyl; or wherein R6 and D are taken together with the atoms to which they are bound to form a 5 to 7 membered ring system wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from O, S, N, NH, SO, or SO2; and wherein said ring is optionally benzofused; D is hydrogen, (C1-C7)-straight or branched alkyl, (C2-C7)-straight or branched alkenyl or alkynyl, or phenyl; wherein 1 to 2 of the CH2 groups of said alkyl, alkenyl or alkynyl chains in D is optionally replaced by â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, â€”S(O2)â€”, or â€”N(R3).