Patent ID: 7588752
Filing Date: 2009-09-15
Classification: A61K,A61P,A61Q,C07K

Abstract:
1. A method of treating or prophylactically treating dental caries or periodontal disease in a subject, the method comprising the step of administering a peptide to the teeth or gums of the subject in need of such treatment, wherein the peptide is selected from: a) a peptide consisting of the amino acid sequence AVESTVATLEASPEVIESPPE (SEQ ID NO:3), wherein serine at amino acid residue 12 of SEQ ID NO:3 is a phosphoseryl residue; b) a peptide consisting of the amino acid sequence AVESTVATLEDSPEVIESPPE (SEQ ID NO:4), wherein serine at amino acid residue 12 of SEQ ID NO:4 is a phosphoseryl residue; c) MAIPPKKNQDKTEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:8), wherein serine at amino acid residue 44 of SEQ ID NO:8 is a phosphoseryl residue; d) a peptide consisting of the amino acid sequence MAIPPKKNQDKTEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:9), wherein serine at amino acid residue 22 and amino acid residue 44 of SEQ ID NO:9 are phosphoseryl residues; e) MAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:10), wherein serine at amino acid residue 44 of SEQ ID NO:10 is a phosphoseryl residue; f) MAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO: 11), wherein serine at amino acid residue 22 and amino acid residue 44 of SEQ ID NO:11 are phosphoseryl residues; g) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:12), wherein serine at amino acid residue 33 of SEQ ID NO:12 is a phosphoseryl residue; h) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:13), wherein serine at amino acid residue 11 and serine at amino acid residue 33 of SEQ ID NO:13 are phosphoseryl residues; i) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:14), wherein serine at amino acid residue 33 of SEQ ID NO:14 is a phosphoseryl residue; and j) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:15), wherein serine at amino acid residue 11 and serine at amino acid residue 33 of SEQ ID NO:15 are phosphoseryl residues.