Patent ID: 6323348
Filing Date: 2001-11-27
Classification: C07C,C07D

Abstract:
A process for producing an optically active compound cycloalkyl[b]benzofuran represented by the formula (IV), comprising: ##STR39##converting a optically active compound represented by formula (III) as a starting material into a compound represented by formula (V) by a reaction using a transition metal, the Mitsunobu reaction, or a combination thereof, andcyclizing the compound represented by formula (V) using a metallic reagent or an organometallic reagent, ##STR40##wherein,R.sup.1 denotes an acyl group with a carbon number of 1 to 12, an aroyl group with a carbon number 7 to 15 or CO.sub.2 R.sup.2 group,R.sup.2 represents a linear or branched alkyl group with a carbon number of 1 to 12, a cycloalkyl group with a carbon number of 3 to 8, or an aryl group with a carbon number of 6 to 11,R.sup.3 denotes a linear or branched alkyl group with a carbon number of 1 to 12, an aralkyl group with a carbon number of 7 to 12, a linear or branched alkylsulfonyl group with a carbon number of 1 to 12, an arylsulfonyl group with a carbon number of 6 to 12, or R.sup.5,R.sup.5 denotes an aryl group with a carbon number of 6 to 11,X denotes halogen,n is an integer in the range of 0 to 4, andY and Z independently denote hydrogen, halogen, an alkyl group with a carbon number of 1 to 5, a cycloalkyl group with a carbon number of 3 to 8, a cycloalkylalkyl group with a carbon number of 4 to 9, a cycloalkenylalkyl group with a carbon number of 5 to 10, an aralkyl group with a carbon number of 7 to 12, an alkenyl group with a carbon number of 2 to 7, or an aryl group with a carbon number of 6 to 11.