Patent ID: 7247645
Filing Date: 2007-07-24
Classification: A61P,C07D

Abstract:
1. A dihydropyridine of formula (1) or a pharmaceutically acceptable salt thereof: wherein A represents a group of formula (2), or 1-naphthyl, 2-naphthyl, thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl, pyridine-2-yl, indole-2-yl or indole-3-yl group: wherein R B represents cyano group, carboxyl group, or a group of formula (3): wherein R C and E may be the same or different from each other and each represent hydrogen atom; a lower alkyl group; dimethoxymethyl group; cyano group; a hydroxy-lower alkyl group; a carboxy-lower alkyl group; a halogeno-lower alkyl group; an amino-lower alkyl group, in which the amino group may be substituted with one or two of a lower alkyl group, a lower cycloalkyl group, an aryl group or an aryl-lower alkyl group; an azido-lower alkyl group; an aryl group; a pyridyl group; a furyl group; an aryl-lower alkyl group; a pyridyl-lower alkyl group; a furyl-lower alkyl group; a pyridyl-lower alkoxymethyl group; a furyl-lower alkoxymethyl group; a pyridinylethoxymethyl group; or a carbamoyl-lower alkyl group, in which the carbamoyl group may be substituted with one or two of a lower alkyl group, a lower cycloalkyl group, an aryl group or an aryl-lower alkyl group; a piperidinylethoxymethyl group; wherein said lower alkyl portion of said lower alkyl group, hydroxy-lower alkyl group, carboxy-lower alkyl group, halogeno-lower alkyl group, amino-lower alkyl group, azido-lower alkyl group, aryl-lower alkyl group, and carbamoyl-lower alkyl group may contain a hetero atom, which is selected from the group consisting of oxygen and nitrogen; D represents a hydrogen atom; F represents a group of formula (4): wherein G and H each represent phenyl group, and I represents hydrogen atom or hydroxyl group; X represents an interatomic bond, —CH Y represents an alkylene group having 2 or 3 carbon atoms.