Patent ID: 8709731
Filing Date: 2014-04-29
Classification: A61K,A61P,C07K,C12Q,G01N,Y10T

Abstract:
1. A method for identifying a subject in need of therapy for a cancer, the method comprising: (a) contacting an antibody against DKK1 protein with a blood or blood derived sample from a subject suspected of suffering from a cancer selected from the group consisting of pancreatic cancer, gastric cancer, prostate cancer, bile duct cancer and cervical cancer to determine a blood concentration of a DKK1 protein in the blood or blood derived sample; (b) obtaining a biological sample comprising pancreatic, gastric, prostate, bile duct, or cervical tissue from the subject by surgery or biopsy if the blood concentration of DKK1 protein in the blood or blood derived sample from the subject is greater than a normal control level in a blood or a blood derived sample; and (c) determining the level of DKK1 protein in the biological sample, and (d) identifying the subject in need of therapy for a cancer if the level of DKK1 protein in the biological sample is greater than the level in a control biological sample comprising pancreatic, gastric, prostate, bile duct, or cervical tissue.