Patent ID: 6554853
Filing Date: 2003-04-29
Classification: A61K

Abstract:
A method for improving a specificity and an extent with which a photosensitizer is taken up by abnormal tissue within a patient, compared to normal tissue, comprising the steps of:(a) providing a microparticle that is characterized by being inert and biocompatible, a photosensitizer, an antibody that is targeted at antigens of the abnormal tissue, and a polymer; (b) conjugating said antibody and said photosensitizer to said microparticle, forming a microparticle based antibody targeted photosensitizer conjugate that is adapted to link with the abnormal tissue; (c) coating said microparticle based antibody targeted photosensitizer conjugate with a polymers forming a polymer coated microparticle based antibody targeted photosensitizer conjugate that is characterized by a prolonged in vivo residence time for the microparticle based antibody targeted photosensitizer conjugate in the patient; and (d) administering the polymer coated microparticle based antibody targeted photosensitizer conjugate to the patient, so that said antibody on the microparticle based antibody targeted photosensitizer conjugate links with the abnormal tissue, uptake of the polymer coated microparticle based antibody targeted photosensitizer conjugate by the abnormal tissue being substantially improved compared with a microparticle based antibody targeted photosensitizer conjugate that is not coated by the polymers and uptake of the polymer coated microparticle based antibody targeted photosensitizer conjugate by the normal tissue being substantially reduced compared with a microparticle based photosensitizer that is coated by the polymer.