Patent ID: 6060487
Filing Date: 2000-05-09
Classification: A61P,C07D

Abstract:
An indanol compound selected from those of formula I: ##STR21## wherein: .diamond-solid.R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, each represents hydrogen or halogen, (C.sub.1 -C.sub.5)alkyl, (C.sub.2 -C.sub.5)alkenyl, or (C.sub.2 -C.sub.5)alkynyl, those radicals being linear or branched, cycloalkylalkyl in which cycloalkyl contains 3 to 7 carbon atoms inclusive and alkyl contains 1 to 5 carbon atoms inclusive, trifluoromethyl, CHO, COOH, COO(C.sub.1 -C.sub.5)alkyl, CO(C.sub.1 -C.sub.5)alkyl, CH.sub.2 OH, hydroxy, (C.sub.1 -C.sub.5)-alkoxy, (C.sub.2 -C.sub.5)alkenoxy, (C.sub.2 -C.sub.5)alkynoxy, benzyloxy, cyano, nitro, or a group of formula: ##STR22## wherein R.sub.5 and R.sub.6, which may be identical or different, each represents hydrogen, halogen, (C.sub.1 -C.sub.5)alkyl, --CO(C.sub.1 -C.sub.5)alkyl, or --COO(C.sub.1 -C.sub.5)alklyl, or.diamond-solid.R.sub.1, R.sub.2, R.sub.3 and R.sub.4 , taken in pairs in adjacent positions, form with the carbon atoms of the phenyl ring to which they are bonded a 5- to 7-membered ring, containing one or more double bonds and consisting of atoms selected from carbon and oxygen, and the rest of these substituents, being not taken in pairs in adjacent positions, each represents a hydrogen atom,.diamond-solid.X--Y represents respectively: ##STR23## .diamond-solid.A forms with the two carbon atoms of the phenyl ring to which it is bonded a 5- to 7-membered heterocycle containing one or more double bonds and comprising one or two heteroatoms, which may be identical or different, selected from oxygen and sulphur,.diamond-solid.Z represents hydrogen or halogen, hydroxy, or (C.sub.1 -C.sub.5)alkoxy,.diamond-solid.Z' represents hydrogen, oxo, hydroxy, (C.sub.1 -C.sub.5)alkoxy, or CH.sub.2 OH,in the form of cis or trans isomers, each of those being in racemic or optically active form, and pharmaceutically-acceptable acid addition salts thereof.