Patent ID: 6911306
Filing Date: 2005-06-28
Classification: C07K,C12Q

Abstract:
1. A method for identifying a subject at risk of developing a cancer characterized by abnormally increased methylation of a CpG island containing TMS1 nucleic acid molecule comprising determining a level of methylation of a CpG island of a TMS1 nucleic acid molecule in a biological sample from a subject, and comparing the level of methylation of the CpG island of the TMS1 nucleic acid molecule in the biological sample to a control wherein the CpG island of the TMS1 nucleic acid molecule is selected from the group consisting of wherein the TMS1 nucleic acid molecule codes for a TMS1 polypeptide comprising a caspase recruiting domain and having apoptosis inducing activity, and wherein an increase in the level of methylation of the CpG island of the TMS1 nucleic acid molecule in the biological sample compared to the control identifies a subject at risk of developing the cancer.