Patent ID: 6465523
Filing Date: 2002-10-15
Classification: C07C,C07D

Abstract:
A compound having the Formula (I): wherein:R1, R2, and R3, are, independently, hydrogen; halogen; nitro; cyano; alkyl of 1 to 10 carbon atoms optionally substituted with halogen; cycloalkyl of 3 to 10 carbon atoms; â€”OR7; amino; alkylamino of 1 to 10 carbon atoms; â€”SO3H; â€”SO2NH2; â€”SONH2; â€”NHSO2R7; â€ƒâ€”SO2R7; carboxyl; aryl of 6 to 12 carbon atoms optionally substituted with one to three substituents each independently selected from the group halogen, carboxy, alkyl of 1 to 10 carbon atoms, nitro, amino, alkoxy of 1 to 10 carbon atoms, and alkyl amino of 1 to 10 carbon atoms; or aroyl of 7 to 12 carbon atoms optionally substituted with one to three substituents each independently selected from the group halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, â€”CF3 and phenyl; A is a moiety selected from the group consisting of â€”CH2â€”, â€”CH&boxH;CHâ€” and â€”CHCOR6; W is carbon wherein the carbon atom may be optionally substituted with â€”R1, â€”R2 and â€”R3; R4is a alkyl of 1 to 10 carbon atoms; cycloalkyl of 3 to 10 carbon atoms; aralkyl of 7 to 20 carbon atoms; wherein the aryl group of the aralkyl group of R4 is optionally substituted with alkyl of 1 to 10 carbon atoms, nitro, halogen cyano, â€”OR7, â€ƒtrifluoromethyl or trifluoromethoxy; R5 is hydrogen; alkyl of 1 to 10 carbon atoms; formyl; alkanoyl of 2 to 7 carbon atoms; alkenoyl of 3 to 7 carbon atoms; â€ƒâ€”SO2R7; aroyl of 7 to 12 carbon atoms optionally substituted with one to three substituents each independently selected from the group halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, â€”CF3 and phenyl; arylalkenoyl of 9 to 20 carbon atoms wherein the aryl group is optionally substituted with one to three substituents each independently selected from the group halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, CF3, and phenyl and substituted phenyl where the substituents are selected from halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms and â€”CF3; arylsulfonyl of 6 to 12 carbon atoms wherein the aryl group is optionally substituted with one to three substituents each independently selected from the group halogen, carboxy, alkyl of 1 to 10 carbon atoms, nitro, amino, alkoxy of 1 to 10 carbon atoms, and alkyl amino of 1 to 10 carbon atoms; arylalkanoyl of 8 to 12 carbon atoms wherein the aryl group is optionally substituted with one to three substituents each independently selected from the group halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, CF3, and phenyl and substituted phenyl where the substituents are selected from halogen, cyano, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms and â€”CF3; or arylalkylsulfonyl of 7 to 12 carbon atoms wherein the aryl group is optionally substituted with one to three substituents each independently selected from the group halogen, carboxy, alkyl of 1 to 10 carbon atoms, nitro, amino, alkoxy of 1 to 10 carbon atoms, and alkyl amino of 1 to 10 carbon atoms; R6 is alkyl of 1 to 10 carbon atoms; or aryl of 6 to 12 carbon atoms wherein the aryl group is optionally substituted with one to three substituents each independently selected from the group halogen, carboxy, alkyl of 1 to 10 carbon atoms, nitro, amino, alkoxy of 1 to 10 carbon atoms, and alkyl amino of 1 to 10 carbon atoms; R7 is a alkyl of 1 to 10 carbon atoms optionally substituted with halogen; Aryl means a homocyclic aromatic radical, whether or not fused, having 6 to 12 carbon atoms optionally substituted with one to three substituents; Aroyl of 7 to 12 carbon atoms refers to â€”C(O)aryl; or pharmaceutically acceptable salts thereof.