Patent ID: 6777443
Filing Date: 2004-08-17
Classification: A61K,A61P,C07K

Abstract:
A compound of the formula whereinR represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl or cycloalkyl-lower alkyl; R1 represents lower alkyl, cycloalkyl, carbocyclic or heterocyclic aryl, or biaryl; or R1 represents (cycloalkyl, carbocyclic aryl, heterocyclic aryl or biaryl)-lower alkyl; alk represents lower alkylene; R3 represents hydrogen or acyl; R4 represents hydrogen, optionally substituted lower alkyl, carbocyclic or heterocyclic aryl, (carbocyclic or heterocyclic aryl)-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl, biaryl-lower alkyl; oxacycloalkyl, thiacycloalkyl, azacycloalkyl, or (oxacycloalkyl, thiacycloalkyl or azacycloalkyl)-lower alkyl; R5 represents hydrogen or lower alkyl; or R4 and R5, together with the carbon atom to which they are attached, represent cycloalkylidene, benzo-fused cycloalkylidene; or 5- or 6-membered (oxacycloalkylidene, thiacycloalkylidene or azacycloalkylidene), each optionally substituted by lower alkyl or aryl-lower alkyl; R6 represents lower alkyl, carbocyclic or heterocyclic aryl, (carbocyclic or heterocyclic aryl)-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl or biaryl-lower alkyl; R7 represents lower alkyl, (carbocyclic or heterocyclic aryl)-lower alkyl, cycloalkyl-lower alkyl or biaryl-lower alkyl; or R6 and R7, together with the carbon atom to which they are attached, represent 3- to 10-membered cycloalkylidene which may be substituted by lower alkyl or aryl-lower alkyl or may be fused to a saturated or unsaturated carbocyclic 5- to 7-membered ring; or 5- or 6-membered (oxacycloalkylidene, thiacycloalkylidene or azacycloalkylidene), each optionally substituted by lower alkyl or aryl-lower alkyl; or 2,2-norbonylidene; X represents â€”Oâ€”, â€”S(O)nâ€”, â€”NHSO2â€”, or â€”NHCOâ€”; n is zero, one or two; and COOR2 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; or a disulfide derivative derived from a said compound wherein R3 is hydrogen; or a pharmaceutically acceptable salt thereof.