Patent ID: 6723742
Filing Date: 2004-04-20
Classification: A61P,C07D,Y10S

Abstract:
A compound of formula (II) wherein each of R1 and R5, independently, is hydrogen; halogen; lower alkyl; halo-lower alkyl; lower alkoxy; halo-lower alkoxy; carboxyl; carbamoyl; N-lower alkylcarbamoyl; N,N-di- lower alkylcarbamoyl; or nitrile; each of R2 and R4, independently, is hydrogen; unsubstituted lower alkanoyl; lower alkanoyl substituted by halogen, hydroxyl, lower alkoxy, trifluoromethyl, cyclo-lower alkyl or phenyl; unsubstituted aroyl; or aroyl substituted by one or two substituents selected from lower alkyl, lower alkoxy, hydroxyl, nitro, halogen, trifluoromethyl, carboxyl, lower alkoxycarbonyl, amino, N-lower alkylamino, N,N-di-lower alkylamino, aminocarbonyl, lower alkylaminocarbonyl, di-lower alkylaminocarbonyl and nitrile; R3 is R6R7Nâ€”C(O)-lower alkyl; aryl substituted by heterocycloalkyl, heteroaryl or heterocycloalkylcarbonyl: aryl-lower alkyl substituted by pyrrolidino; unsubstituted heteroaryl; heteroaryl substituted by one or two substituents selected from lower alkyl, halogen, trifluoromethyl, carboxyl and lower alkoxycarbonyl; unsubstituted heteroaralkyl; or heteroaralkyl substituted by one or two substituents selected from lower alkyl, halogen, trifluoromethyl, carboxyl and lower alkoxycarbonyl; and R6 and R7, together with the nitrogen atom to which they are bonded, form an unsubstituted azaalicyclic ring; or an azaalicyclic ring substituted by halogen or lower alkyl; or a salt thereof.