Patent ID: 6951955
Filing Date: 2005-10-04
Classification: A61K,C07B,C07C,C07K

Abstract:
1. A process for the preparation of a compound of Formula I: wherein: R R R R comprising: a) treating a nitrile of the formula: with a reducing agent followed by acid hydrolysis to obtain an aldehyde of the formula: b) reacting the aldehyde (step a) with alkali metal cyanide in the presence of an alkyl amine of the formula R c) hydrolyzing the nitrile (step b) with an alkali metal hydroxide to give an amide of the formula: d) reacting the amide (step c) with an organic carbonate, of the formula O[CO e) hydrolyzing triblocked amide (step d) with an alkali metal hydroxide to give racemic blocked amine of the formula: f) reacting racemic blocked amine (step e) with a resolving base (NH and g) treating the resolved blocked amine salt with aqueous alkali metal hydroxide and acidifying with acid to give a compound of Formula I: