Patent ID: 7211695
Filing Date: 2007-05-01
Classification: C07B,C07C,C07D,C07K,C40B,G01N

Abstract:
1. A process for preparing a compound of formula (II′): wherein Ar or a protected derivative thereof; wherein the stereochemistry at *C is (R), (S), or (RS); W is alkylene; Ar X is a bond; Q is —N(R R or a salt thereof; the process comprising: (a) deprotecting a compound of formula (II′) wherein Ar (b) deprotecting a compound of formula (II′) wherein R (c) (i) reacting a compound of formula (1):  with a compound of formula (2):  to form a reaction mixture; to the reaction mixture of step (c)(i); then adding a reducing agent; (d) reacting a compound of formula (1) with a compound of formula (a):  then adding a reducing agent; (e) reacting a compound of formula (a) with a compound of formula (b): (f) when Ar and for steps (a), (b), (c), (d), (e), and (f), optionally removing any protecting groups; to provide a compound of formula (II′) or a salt thereof.