Patent ID: 6268516
Filing Date: 2001-07-31
Classification: A61K,C07C,C07J,C12N

Abstract:
Cationic lipids for liposomal gene transfer comprising a general formula Ia, ##STR19##wherein n=2, 3, 4, 6, or 8 and m=2, 3, 6, or 8 and R.sub.1 =H, CH.sub.3, or CH.sub.2 CH.sub.2 OH; R.sub.2 =H, CH.sub.3, CH.sub.2 CH.sub.2 OH, or (CH.sub.2).sub.3 N.sup.+ (R.sub.1).sub.3, R.sub.3 =H, CH.sub.3, CH.sub.2 CH.sub.2 OH, or (CH.sub.2).sub.3 N.sup.+ (R.sub.1).sub.3, R.sub.4 represents a straight chain saturated or unsaturated aliphatic group C.sub.7 -C.sub.21, Z=CH.sub.2, O, or NH, Y=CH.sub.2, O or NH and X=Cl, Br, I, CH.sub.3 COO, or CF.sub.3 COO.