Patent ID: 6485514
Filing Date: 2002-11-26
Classification: A61K,A61L

Abstract:
A method for treating restenosis of a blood vessel by using a water-insoluble camptothecin compound in combination with a stent to treat tissue of the blood vessel, the method comprising:coating a stent with a water-insoluble camptothecin compound dispersed in 1% poly(L-lactic acid) solution in chloroform inserting the stent into a blood vessel; supporting the blood vessel with the stent to mechanically prevent the collapse and reocclusion of the blood vessel; and contacting tissue forming the blood vessel with the water-insoluble camptothecin compound, wherein the water-insoluble camptothecin compound is selected from the group consisting of 9-nitro-20(S)-camptothecin and 9-amino-20(S) camptothecin in a concentration sufficient to reduce restenosis In the blood vessel.