Patent ID: 6294332
Filing Date: 2001-09-25
Classification: A61K,C07K,C12N

Abstract:
A method of modulating the length of telomeres, comprising the step of administering to a cell in vitro, an amount of a molecule sufficient to modulate telomere length, wherein said molecule is:a) a nucleic acid sequence encoding hnRNP A1;b) a nucleic acid sequence encoding UP1;c) a trypsin-like protease involved in the conversion of hnRNP A1 into UP1;d) a purified hnRNP A1 polypeptide;e) a purified UP1 polypeptide;f) an hnRNP A1 nucleic acid molecule that is in vitro mutagenized in the portion which is absent in UP1, or a deletion, insertion, or fusion of the nucleic acid molecule of a) or b);g) an hnRNP A1 polypeptide that is in vitro mutagenized in the portion which is absent in UP1, or a deletion, insertion, or fusion of the molecule of any of c)-e); orh) an agent which is specific for hnRNP A1 and/or UP1.