Patent ID: 7943342
Filing Date: 2011-05-17
Classification: A61K,A61P,C07K

Abstract:
1. A purified nucleic acid molecule comprising a nucleotide sequence that encodes a heavy chain immunoglobulin variable domain of an antibody molecule that binds to IL-13 with a K D of less than 10 −7 M, wherein the heavy chain immunoglobulin variable domain comprises the amino acid sequence of: wherein the nucleotide sequence encoding the heavy chain immunoglobulin variable domain comprises a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence that hybridizes under high stringency conditions in 6×SSC at about 45° C. followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C. to either (i) the complement of the nucleotide sequence encoding the heavy chain variable domain of V2.11 as set forth in SEQ ID NO:80, or (ii) the complement of the nucleotide sequence set forth in SEQ ID NO:172; (b) a nucleotide sequence (i) that encodes an amino acid sequence that is at least 90% identical to the amino acid sequence of the heavy chain variable domain of V2.11 as set forth in SEQ ID NO:80, or (ii) that is 90% identical to the nucleotide sequence set forth in SEQ ID NO:172; (c) a nucleotide sequence (i) that encodes an amino acid sequence that is at least 95% identical to the amino acid sequence of the heavy chain variable domain of V2.11 as set forth in SEQ ID NO:80, or (ii) that is 95% identical to the nucleotide sequence set forth in SEQ ID NO:172; (d) a nucleotide sequence encoding the amino acid of the heavy chain variable domain of V2.11 as set forth in SEQ ID NO:80; and (e) a nucleotide sequence comprising the nucleotide sequence set forth in SEQ ID NO:172.