Patent ID: 6462038
Filing Date: 2002-10-08
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 is selected from the group of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)mR9, C1-C8 alkyl, C1-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, C1-C8 aryl, C1-C8 arylalkyl, C1-C8 heteroaryl, C2-C8 alkynyl, and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted; R2 is selected from the group of F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)mR9, NR10R11, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, aryl, arylalkyl, heteroaryl, C2-C8 alkynyl, and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted; R3 is selected from the group of hydrogen, F, Cl, Br, I, OR9, S(O)mR9, NR10R11, or C1-C6 alkyl, C1-C6 heteroalkyl and C1-C6 haloalkyl and wherein the alkyl, heteroalkyl and haloalkyl groups are optionally substituted; R4 and R5 are each independently selected from the group of hydrogen, OR9, S(O)mR9, NR10R11, C(Y)OR11, C(Y)NR10R11, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, aryl, arylalkyl, heteroaryl, C2-C8 alkynyl, and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted, or R4 and R5 taken together form a saturated or unsaturated three- to seven-membered ring that is optionally substituted; R6 and R7 are each independently selected from the group of hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, aryl, arylalkyl, heteroaryl, C2-C8 alkynyl, and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted, or R6 and R7 taken together form a saturated or unsaturated three- to seven-membered ring that is optionally substituted, or R6 and R5 taken together form a saturated or unsaturated three- to seven-membered ring that is optionally substituted; R8 is selected from the group of hydrogen, C1-C4 alkyl, C1-C4 heteroalkyl, C1-C4 haloalkyl, F, Cl, Br, I, NO2, OR9, NR10R11 and S(O)mR9 and wherein the alkyl, heteroalkyl and haloalkyl groups are optionally substituted; R9 is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, aryl, heteroaryl, arylalkyl, C2-C4 alkynyl and C2-C8 alkenyl and wherein the alkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted; R10 is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, C(Y)R12, C(Y)OR12, aryl, heteroaryl, C2-C4 alkynyl, C2-C8 alkenyl, arylalkyl, SO2R12 and S(O)R12 and wherein the alkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted; R11 is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, aryl, heteroaryl, arylalkyl, C2-C4 alkynyl and C2-C8 alkenyl and wherein the alkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted; R12 is selected from the group of hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, aryl, heteroaryl, arylalkyl, C2-C4 alkynyl and C2-C8 alkenyl and wherein the alkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, alkynyl, and alkenyl groups are optionally substituted, R13 is selected from the group of hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, C2-C4 alkynyl and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkynyl, and alkenyl groups are optionally substituted; or R13 and R4 taken together form a saturated or unsaturated three- to seven-membered ring that is optionally substituted; or any two of R4 through R7, and R13 taken together form a saturated or unsaturated three- to seven-membered ring that is optionally substituted; R14 and R15 are each independently selected from the group of hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, aryl, heteroaryl, arylalkyl, C2-C8 alkynyl and C2-C8 alkenyl and wherein the alkyl, cycloalkyl, heteroalkyl, haloalkyl, aryl, heteroaryl, arylalkyl, alkynyl and alkenyl are optionally substituted; m is 0, 1 or 2; V is selected from the group of O, S and CR14R15; W is selected from the group of O, S, NH, NR13, NC(Y)R11 and NSO2R11; X and Z each independently is selected from the group of O, S(O)m, NH, NR11, NC(Y)R11, NSO2R12 and NS(O)R12; and Y is O or S; wherein when W is O or S, X is selected from the group of NH, NR11, NC(Y)R11, NSO2R12, and NS(O)R12; and wherein when X is O or S(O)m, W is selected from the group of NH, NR13, NC(Y)R11, and NSO2R11; and pharmaceutically acceptable salts thereof.