Patent ID: 6350761
Filing Date: 2002-02-26
Classification: A61P,C07D

Abstract:
A compound of formula (I): wherein:A is â€”Oâ€” or â€”N(R7)â€”; W is â€”N(R4)â€”, â€”Sâ€” or â€”Oâ€”; each m is independently 0, 1, 2, 3 or 4; n is 0 or 1; R1 is hydrogen, alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, â€”C(NH)â€”NH2, â€”C(NH)N(H)OR7, â€”C(NH)N(H)C(O)OR9, â€”C(NH)N(H)C(O)R9, â€”C(NH)N(H)S(O)2R9, or â€”C(NH)N(H)C(O)N(H)R7), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, â€”C(NH)â€”NH2, â€”C(NH)N(H)OR7, â€”C(NH)N(H)C(O)OR9, â€”C(NH)N(H)C(O)R9, â€”C(NH)N(H)S(O)2R9, or â€”C(NH)N(H)C(O)N(H)R7), mono[dialkoxycarbonyl]alkylaminocarbonyl, mono[dicarboxy]alkylaminocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl; R2 is â€”[C(R7)2]mâ€”, â€”[C(R7)2]mâ€”C(O)â€”N(R8)â€”, or â€”[C(R7)2]mâ€”[C(R8)]&boxH;CHâ€”; or R2 is R3 is â€”C(NH)NH2, â€”C(NH)N(H)OR7, â€”C(NH)N(H)C(O)OR9, â€”C(NH)N(H)C(O)R9, â€”C(NH)N(H)S(O)2R9, or â€”C(NH)N(H)C(O)N(H)R7; R4 is hydrogen, alkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or â€”C(NH)CH3; each R5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; R6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy); each R7 and R8 is independently hydrogen, alkyl, aryl, or aralkyl; and each R9 is alkyl or aralkyl; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.