Patent ID: 7956182
Filing Date: 2011-06-07
Classification: C07B,C07C,C07D

Abstract:
1. A process for producing an optically active alcohol of formula (V) comprising the steps of reducing an aromatic ketone represented by formula (I), (II) or (III), wherein R 1 is selected from a hydrogen atom, halogen atom, lower alkyl group having 1 to 5 carbon atoms, lower haloalkyl group having 1 to 5 carbon atoms, lower alkoxycarbonyl group having 1 to 5 carbon atoms, lower alkoxy group having 1 to 5 carbon atoms, hydroxyl group, nitro group, cyano group, lower acyloxy group having 1 to 5 carbon atoms, lower alkylthio group having 1 to 5 carbon atoms, lower alkylsulfonyl group having 1 to 5 carbon atoms, substituted and unsubstituted amino group, substituted and unsubstituted carbamoyl group, substituted and unsubstituted aromatic ring or heterocyclic group, R 2 is —(CH 2 )n-R 3 wherein n is an integer of from 1 to 5, R 3 is selected from a hydrogen atom, halogen atom, lower alkoxycarbonyl group having from 1 to 5 carbon atoms, lower alkoxy group having from 1 to 5 carbon atoms, lower alkylthio group having from 1 to 5 carbon atoms, lower alkylsulfonyl group having from 1 to 5 carbon atoms, substituted and unsubstituted amino group, unsubstituted carbamoyl group, substituted and unsubstituted aromatic ring or heteroaromatic ring, formula (II) wherein R 4 is a lower alkyl group having from 1 to 5 carbon atoms, substituted and unsubstituted aromatic ring, and substituted and unsubstituted benzyl group, and formula (III): wherein R 5 and R 6 are the same or different and are selected from a hydrogen atom, halogen atom, lower alkyl group having 1 to 5 carbon atoms, lower haloalkyl group having 1 to 5 carbon atoms, lower alkoxycarbonyl group having 1 to 5 carbon atoms, lower alkoxy group having 1 to 5 carbon atoms, lower acyloxy group having 1 to 5 carbon atoms, hydroxyl group, nitro group, cyano group, substituted and unsubstituted benzyloxy group, substituted silyloxy group, lower alkylthio group having 1 to 5 carbon atoms, lower alkylsulfonyl group having 1 to 5 carbon atoms, substituted and unsubstituted amino group, substituted and unsubstituted carbamoyl group, substituted and unsubstituted aromatic ring or heteroaromatic ring, substituted and unsubstituted tetrahydropyranyl group, lower alkyl group containing a substituted or unsubstituted tetrahydropyranyl group having 1 to 5 carbon atoms, lower alkyl group containing an amino group having 1 to 5 carbon atoms, by sodium borohydride, chlorotrimethylsilane and an optically active 2-[bis(4-methoxyphenyl)hydroxy-methyl]pyrrolidine represented by formula (IV) to give the optically active alcohol.