Patent ID: 6110970
Filing Date: 2000-08-29
Classification: C07C,C07D

Abstract:
A compound represented by the formula: ##STR16## wherein R is C.sub.3 to C.sub.6 alkyl, alkenyl or alkynyl, any of which can be optionally substituted with aryl, heteroaryl, halo, alkyl, alkoxy, hydroxy, amino, cyano, nitro, trifluoromethyl, acylamino or carbamoyl;R.sup.1 and R.sup.2 are independently H, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, or C.sub.2 -C.sub.10 alkynyl, any of which can be optionally substituted with halo, alkoxy, amino, trifluoromethyl, aryl or heteroaryl;R.sup.3 is(1) a nitrogen-containing heterocycloalkyl or heteroaryl group, wherein said heteroaryl group can have up to two additional substituents;(2) an aryl or aralkyl group having one or two nitrogen-containing substituents selected from the group consisting of amino, monoalkylamino, dialkylamino, trialkylammonium salts, and acylamino, wherein said aryl or aralkyl group can have up to two additional substituents; or(3) a C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, or C.sub.5 to C.sub.7 cycloalkyl group having one or two nitrogen-containing substituents selected from the group consisting of amino, monoalkylamino, dialkylamino, trialkylammonium salts, acylamino, arylcarbonylamino and ureido; ora pharmaceutically-acceptable salt thereof;with the provisos that R is not substituted or unsubstituted n-propyl; that when R is t-butyl and R.sup.1 and R.sup.2 are both hydrogen, then R.sup.3 can not be 3-aminopropyl or 3-(t-butoxycarbonylamino)propyl; that when R is isopropyl and R.sup.1 and R.sup.2 are both hydrogen, then R.sup.3 can not be 2-amino-6-chlorophenyl or 8-(3,7-dichloroquinoline); and that when R is isopropyl, R.sup.1 is hydrogen, and R.sup.2 is methyl, then R.sup.3 can not be 4-(methylamino)cyclohexane.