Patent ID: 6730700
Filing Date: 2004-05-04
Classification: C07C

Abstract:
A method for treating a mammal with an inflammation-related condition selected from the group consisting of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and systemic lupus erythematosus which method comprises administering to said mammal a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective inflammation-reducing amount of a compound of formula I: whereinR1 is selected from the group consisting of: each R2 is independently selected from a group of the formula: R3 is selected from the group consisting or hydrogen, alkyl, cycloalkyl and aryl; R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R5 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; or R6 and R7 can be joined to form an alkylene or substituted alkylene group having from 2 to 10 carbon atoms; R8 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; or R8 and R9 can be joined to form an alkylene or substituted alkylene group having from 2 to 10 carbon atoms; R10 is selected from the group consisting of hydrogen, lower alkyl and lower cycloalkyl; or R1 and R10 can be joined to form an alkylene, substituted alkylene, â€”C(O)â€”â€”S(O)â€” or â€”S(O)2â€” group; R11 and R12 are independently selected from the group consisting of lower alkyl and lower cycloalkyl; or R11 and R12 can be joined to form an alkylene group having from 2 to 10 carbon atoms; X is oxygen, sulfur, â€”S(O)â€” or â€”S(O)2â€”; and W is oxygen or sulfur; and pharmaceutically-acceptable salts thereof.