Patent ID: 7094550
Filing Date: 2006-08-22
Classification: A61K,C07K,G01N

Abstract:
1. An in vitro method comprising: (a) contacting a mammalian physiological sample with a capture moiety comprising a TGF-beta type II receptor extracellular domain to form a capture complex; (b) contacting the capture complex with a detection moiety to form a detectable complex, wherein the detection moiety is capable of binding to TGF-beta-1 or TGF-beta-3, and comprises a detectable label or a site which binds a detectable label; and (c) detecting the presence of the detectable complex, thereby identifying a mammal at risk for atherosclerosis or the effect of administering to a mammal a therapeutic agent which increases the level of TGF-beta-1 or TGF-beta-3 in the sample that is bound by the capture and detection moieties.