Patent ID: 8697049
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated genetically modified bacteriophage, which inhibits Staphylococcus aureus growth, said bacteriophage comprising an α/β small acid-soluble spore protein (SASP) gene encoding a SASP which is toxic to S. aureus , wherein the SASP gene is under the control of a constitutive promoter which is foreign to the bacteriophage and the SASP gene, which promoter drives the production of toxic levels of SASP when present in multiple copies in S. aureus , wherein a lysis gene of the bacteriophage genome is inactivated, wherein the modified bacteriophage is lysogenic and contains a single copy of the SASP gene functionally linked to said constitutive bacterial promoter, and wherein said bacteriophage is selected from the group consisting of: bacteriophage Twort, bacteriophage tIII-29S, bacteriophage ΦPVL, bacteriophage ΦPV83, bacteriophage Φ11, bacteriophage Φ12, bacteriophage Φ13, bacteriophage Φ42, bacteriophage Φ812, bacteriophage K, bacteriophage P3, bacteriophage P14, bacteriophage UC18, bacteriophage 15, bacteriophage 17, bacteriophage 29, bacteriophage 42d, bacteriophage 47, bacteriophage 52, bacteriophage 53, bacteriophage 79, bacteriophage 80, bacteriophage 81, bacteriophage 83, bacteriophage 85, bacteriophage 93, bacteriophage 95, and bacteriophage 187.