Patent ID: 6358949
Filing Date: 2002-03-19
Classification: C07D

Abstract:
A compound of the formula: or pharmaceutically acceptable salts thereof wherein:R1 is not 3-fluorobenzyl and represents (i) (C2-C6)alkenyl; or (ii) R1 represents aryl(C1-C6)alkyl or heteroaryl(C1-C6)alkyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, nitro, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, amino, mono- or di(C1-C6)alkylamino, amino(C1-C6)alkyl, mono- or di(C1-C6)alkylamino(C1-C6)alkyl, mono- or di(C1-C6)alkylamino(C1-C6)alkoxy, or (iii) OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7 where n=1, 2, 3, or 4 and R7 and R8 are the same or different and represent hydrogen, SO2Me, or (C1-C6)alkyl; or R7 and R8 together with the nitrogen to which they are attached form a 5, 6 or 7 membered carbocyclic ring where up to two of the members in the ring are optionally hetero atoms selected from oxygen, sulfur and nitrogen, and where each member is optionally substituted with (C1-C6)alkyl; R2 represents hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, amino(C1-C6)alkyl, mono- or di(C1-C6)alkylamino(C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7 where n=1, 2, 3, or 4; and R7 and R8 are the same or different and represent hydrogen, SO2Me, or (C1-C6)alkyl; or R7 and R8 together with the nitrogen to which they are attached form a 5, 6 or 7 membered carbocyclic ring where up to two of the members are optionally hetero atoms selected from oxygen, sulfur and nitrogen, and where each member is optionally substituted with (C1-C6)alkyl; R3 represents (C1-C6)alkyl; R4 represents halogen or trifluoromethyl; R5 and R6 are the same or different and represent hydrogen, trifluoromethyl, trifluoromethoxy, cyano, (C1-C6)alkyl, halogen, (C1-C6)alkylamino(C1-C6)alkyl, mono or di(C1-C6)alkylamino(C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or R4 and R5 together with the carbon atoms to which they are attached form a 5 or 6 membered aromatic ring which is optionally substituted with one or two groups independently selected from halogen, nitro, trifluoromethyl, cyano, hydroxy, (C1-C6)alkyl, amino, or mono- or di(C1-C6)alkylamino; or OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7 where n=1, 2, 3, or 4; and R7 and R8 are the same or different and represent hydrogen, SO2Me, or (C1-C6)alkyl; or R7 and R8 together with the nitrogen to which they are attached form a 5, 6 or 7 membered carbocyclic ring where up to two of the members are optionally hetero atoms selected from oxygen, sulfur and nitrogen, and where each member is optionally substituted with (C1-C6)alkyl; X represents a bond or CH2, where the CH2 is optionally mono- or disubstituted with a (C1-C6)alkyl or (C1-C6)alkoxy; and A, B, C and D are the same or different a represent CRp or N where Rp represents hydrogen or C1-C6 alkyl or C1-C6 alkoxy where the alkyl portion of each is optionally substituted with carboxy, halogen, amino, or mono- or di(C1-C6)alkylamino, with the proviso that not more than two of A, B, C and D represent N.