Patent ID: 7049294
Filing Date: 2006-05-23
Classification: A61K,A61P

Abstract:
1. A method of treating a chronic skin ulcer in a subject, said method comprising administering to the chronic skin ulcer an effective amount of a polypeptide of between 14 to 23 amino acids in length, wherein the polypeptide comprises a thrombin receptor binding domain of the sequence Arg-Gly-Asp-Ala (SEQ ID NO.: 7) and a serine esterase conserved sequence, wherein the polypeptide is administered to the chronic skin ulcer for a duration sufficient to achieve at least 80% closure of the chronic skin ulcer, and wherein the polypeptide is administered to the chronic skin ulcer alone or in combination with an antimicrobial, a disinfectant, an antibiotic, an analgesic or an anti-inflammatory agent.