Patent ID: 6590071
Filing Date: 2003-07-08
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A compound of Formula I in which R2 is selected from the group consisting of hydrogen, lower alkyl, and aryl, wherein the lower alkyl and aryl are optionally substituted with one or more alkoxy, alkanoyl, nitro, cycloalkyl, alkenyl, alkynyl, acyloxy, lower alkyl or halogen;R3 is a naturally occurring lipid, a hydrophobic branched or unbranched hydrocarbon comprising about 4 to about 26 carbon atoms, a fatty acid or ester thereof, or a surfactant; one of R4 and R5 is a biologically active amino group-containing substance selected from the group consisting of an amine-containing drug, a natural or unnatural amino acid, a peptide and a protein and the other of R4 and R5 is OR6 where R6 is selected from the group consisting of hydrogen, an alkali metal and a negative charge; X is oxygen or sulfur; Y is a bridging natural or unnatural amino acid; n is zero or 1; and m is an integer from zero to 10.