Patent ID: 9078418
Filing Date: 2015-07-14
Classification: A01K,C07K,C12N

Abstract:
1. A genetically modified mouse, wherein the genome of said mouse comprises a replacement at an endogenous mouse IL-6 locus of a mouse gene encoding IL-6 with a human gene encoding human IL-6, wherein the human gene encoding human IL-6 is under control of endogenous mouse regulatory elements at the endogenous mouse IL-6 locus and is expressed, and the replaced mouse IL-6 gene is not expressed; wherein the genome of said mouse further comprises a replacement at an endogenous mouse IL-6Rα locus of a mouse nucleic acid encoding a mouse IL-6Rα ectodomain with a human nucleic acid encoding a human IL-6Rα ectodomain to form a humanized IL-6Rα gene, wherein the humanized IL-6Rα gene is under control of endogenous mouse regulatory elements at the endogenous mouse IL-6Rα locus, wherein the humanized IL-6Rα gene is expressed and encodes a humanized IL-6Rα protein which comprises said human IL-6Rα ectodomain and mouse IL-6Rα transmembrane and cytoplasmic domains; and wherein the mouse exhibits an acute phase response to an acute phase inducer.