Patent ID: 9045443
Filing Date: 2015-06-02
Classification: A61K,A61P,C07C,C07D

Abstract:
1. A compound of formula I: where: R R a is an integer from 2-5; R R R Z is —CH— or —N—; X is selected from —COOR R R R where R 40 is selected from —C 1-6 alkyl, —O—C 1-6 alkyl, —C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 41 R 42 , —CH[CH(CH 3 ) 2 ]—NH 2 , —CH[CH(CH 3 ) 2 ]—NHC(O)O—C 1-6 alkyl, and —CH(NH 2 )CH 2 COOCH 3 ; R 41 and R 42 are independently selected from H, —C 1-6 alkyl,and benzyl; or R 41 and R 42 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 O(CH 2 ) 2 —; and R 43 is selected from —O—C 1-6 alkyl, —O-benzyl, and —NR 41 R 42 ; b is 0 or 1; R c is 0 or an integer from 1 to 3; each R where each alkyl group in X is optionally substituted with 1 to 8 fluoro atoms; or a pharmaceutically acceptable salt thereof.