Patent ID: 6051226
Filing Date: 2000-04-18
Classification: A61K,A61P,C07K

Abstract:
A method of delivering a chemotherapeutic agent or toxic agent to a vertebrate cancer cell, which is abnormally expressing MN protein, wherein said method comprises contacting the cell with an antibody, or a biologically active antibody fragment, which antibody or antibody fragment specifically binds to a cell surface epitope of an MN protein and is linked to a chemotherapeutic agent or toxic agent;wherein said MN protein is encoded by a nucleotide sequence selected from the group consisting of:(a) SEQ ID NOS: 1 and 5;(b) nucleotide sequences that hybridize under stringent hybridization conditions of 0.15 to 0.9 M salt in the presence of 50% formamide at 42.degree. C. to the complements of SEQ ID NOS: 1 and 5, with a final wash of 0.1% SSPE and 0.1% SDS at 65.degree. C.; and(c) nucleotide sequences that differ from SEQ ID NOS: 1 and 5, or from the nucleotide sequences of (b) in codon sequence due to the degeneracy of the genetic code; wherein said cancer cell is not from stomach tissue.