Patent ID: 9152758
Filing Date: 2015-10-06
Classification: A61P,G06K,G16B,Y02A,Y10T

Abstract:
1. A method of analyzing a mass spectrum, comprising the steps of: a) obtaining a mass spectrum of a blood-based sample from a human patient; b) subtracting background contained in the mass spectrum to produce a background subtracted spectrum, wherein the subtracting step comprises (i) estimating, in a moving window comprising a range of m/z values in said mass spectrum using robust asymmetric estimates, nonconstant levels of background and (ii) subtracting the estimated background from the mass spectrum; c) normalizing the background subtracted spectrum; d) aligning the normalized, background subtracted spectrum to a predefined mass scale, the predefined mass scale associated with common peaks or peak clusters identified from a group of other mass spectra from other blood-based samples; and e) classifying the mass spectrum using a training set comprising class-labeled mass spectra of blood-based samples of other human patients; wherein the aligning step d) further comprises the step of aligning the normalized, background subtracted spectrum to a list of peak clusters identified from a group of mass spectra from blood-based samples which are both close in m/z position and well separated from each other in the m/z axis; wherein the list of peak clusters are characterized by a center (m/z position) and a width (m/z range), and wherein one or more of the following m/z positions are within the list of peak clusters: 6434.50, 6632.18, 11686.94, 15131.14, 15871.47 and 28102.55.