Patent ID: 8765670
Filing Date: 2014-07-01
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A Growth Differentiation Factor-3 (GDF3) propeptide fusion protein comprising: a first polypeptide comprising a GDF3 propeptide and a heterologous polypeptide covalently fused to the first polypeptide, wherein the GDF3 propeptide comprises an amino acid sequence at least 95% identical to amino acids 1-219 of SEQ ID NO: 1, wherein the GDF3 propeptide contains no more than 20 contiguous amino acids of the mature portion of human GDF3; and wherein the GDF3 propeptide has one or more of the following characteristics: i) binds to mature GDF3 with a Kd of at least 10 ii) inhibits GDF3 signaling in a cell.