Patent ID: 6673341
Filing Date: 2004-01-06
Classification: A61K,A61P,C07K,G01N

Abstract:
A method of inhibiting a proliferative disease in a vertebrate, wherein the proliferative disease is characterized by cells that secrete endogenous TGF-&bgr; and the disease is further characterized by angiogenesis, comprising inhibiting endogenous TGF-&bgr; activity by contacting the proliferating cells with less than 5 mg of an anti-TGF-&bgr; antibody, resulting in the inhibition of endogenous TGF-&bgr;-mediated angiogenesis, thereby inhibiting the proliferative disease, wherein the proliferative disease is selected from the group consisting of benign tumors and malignant tumors, and wherein the proliferative disease is clear-cell renal carcinoma.