Patent ID: 8697070
Filing Date: 2014-04-15
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated cDNA encoding a PCSK9 specific antagonist antibody or antigen binding fragment thereof, wherein the antibody or antigen binding fragment comprises: a) a heavy chain variable region comprising a CDR1 domain having the amino acid sequence of SEQ ID NO: 13; a CDR2 domain having the amino acid sequence of SEQ ID NO: 15; and a CDR3 domain having the amino acid sequence of SEQ ID NO: 17; and/or b) a light chain variable region comprising a CDR1 domain having the amino acid sequence of SEQ ID NO: 3; a CDR2 domain having the amino acid sequence of SEQ ID NO: 5; and a CDR3 domain having the amino acid sequence of SEQ ID NO: 7; wherein the PCSK-9 specific antagonist antibody or antigen binding fragment thereof antagonizes PCSK-9 mediated inhibition of cellular LDL uptake.