Patent ID: 6753014
Filing Date: 2004-06-22
Classification: A61K

Abstract:
A method of preparing homogeneous microparticles comprising a pharmaceutically active substance, wherein the method uses a spray freezing technique and comprises the steps of:a) atomizing into droplets a liquid medium having a minimum dry content of 15% by volume and comprising: i) a pharmaceutically active substance; ii) a polymer selected from the group consisting of water soluble polymers and non-water soluble polymers, said polymer being present in an amount of at least 5 per cent by weight based upon the dry content of the medium; iii) a liquid in which the pharmaceutically active substance and polymer are suspended, dissolved or emulsified; and iv) optionally a dispersing agent; b) freezing the formed droplets; and c) sublimating the frozen liquid of the droplets to obtain dry, homogeneous microparticles.