Patent ID: 8324361
Filing Date: 2012-12-04
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A nucleic acid molecule encoding a soluble Frizzled (FZD) receptor, wherein the soluble FZD receptor comprises: (a) a fragment of the extracellular domain of a human FZD receptor comprising the Fri domain of the human FZD receptor; and (b) a non-FZD receptor protein sequence comprising human Fc, wherein the fragment of the extracellular domain of the human FZD receptor is linked in-frame to the non-FZD receptor protein sequence, and wherein the soluble FZD receptor has a longer half-life in vivo than a soluble FZD receptor comprising the extracellular domain of the FZD receptor linked in-frame to the non-FZD receptor protein sequence.