Patent ID: 8252776
Filing Date: 2012-08-28
Classification: A61K,A61P

Abstract:
1. A method of distributing an oral dosage form, comprising: providing the oral dosage form, wherein the oral dosage form includes an oral minocycline and a slow continuous release vehicle for controlling release of the minocycline so that the minocycline is released in the patient, without an initial load dose, and at a release rate in gastric fluid that is either about 25% to about 52% within 1 hour, about 53% to about 89% within 2 hours, and at least 90% within about 4 hours, or about 30% to about 52% within 1 hour, about 53% to about 84% within 2 hours, and at least 85% within about 4 hours, and wherein the oral dosage form is administered, once daily, to the patient to provide the patient with about 0.70 mg/kg/day to about 1.3 mg/kg/day of the minocycline; distributing information for selection of the oral dosage form based on the body weight of the patient; and concomitantly distributing information that the oral dosage form may cause one or more adverse effects selected from pseudomembranous colitis, hepatotoxicity, vasculitis, tissue hyperpigmentation, and anaphylaxis.