Patent ID: 6063400
Filing Date: 2000-05-16
Classification: A61K,A61P,B82Y,Y10S

Abstract:
A liposomal construct for delivering a diagnostic or therapeutic agent to a mammal comprising:a) a liposomal carrier;b) a diagnostic or therapeutic agent comprising a biogenic amine selected from the group consisting of L-.beta.-3,4dihydroxyphenylanine, 3-(2-aminoethyl)-5-hydroxyindole, 2-(4-imidazolyl)ethylamine, 4-[1-hydroxy-2-[(methylamino)]ethyl]-1,2-benzenediol, 1-[3,4-dihydroxyphenyl]-2-aminoethanol, .gamma.-amino-n-butyric acid and acetylcholine, entrapped within or associated with said liposomal carrier; andc) a separate sequestering agent selected from the group consisting of a nucleotide derivative selected from the group consisting of adenosine 5'-triphosphate (ATP), cytidine 5'-triposphate(CTP), guanosine 5'-triphosphate (GTP), thymidine 5'triphosphate (TTP), uridine 5'-triphosphate (UTP), adenosine 5'-diphosphate (ADP), cytidine 5'-diphosphate (CDP), guanosine 5'-diphosphate (GDP), thymidine 5'-diphosphate (TDP), uridine 5'-diphosphate (UDP), adenosine 5'-monophosphate (AMP),cytidine 5'-monophosphate (CMP), guanosine 5'-monophosphate (GMP), thymidine 5'-mononhosphate (TMP), uridine 5'-monophosphate (UMP), adenosine 5'-tetraphosphate, guanosine 5'-tetraphosphate and thymidine 5'-tetraphosphate, a polyphosphate derivative selected from the group consisting of phytic acid and the hexaphoshate of inositol and phosvitin, and an amino acid polymer, distributed within said liposomal carrier, said sequestering agent being present in an amount effective to reduce leakage of the diagnostic or therapeutic agent from the liposomal construct prior to delivery and being in addition to said diagnostic or therapeutic agent.