Patent ID: 6653331
Filing Date: 2003-11-25
Classification: A61K,C07D

Abstract:
A method of depleting intracellular Reduced Glutathione (GSH) levels in vivo which comprises utilizing an effective amount of a compound of the formula ID1-A1â€ƒâ€ƒI wherein D1 is Phâ€”CH(NH)â€”CH(OH)â€”COOCH3 or Phâ€”CH(NH)â€”COOCH3 and wherein the nitrogen atom of the NH group in D1 being covalently bonded to the sulfur atom of an A1 moiety; wherein the A1 moiety is: wherein X1 is a) â€”Câ€”, or b) â€”Nâ€”; wherein X2 is a) â€”Nâ€”, or b) â€”Sâ€”; wherein R1 is a) â€”H, b) â€”NO2, c) â€”Cl, d) â€”CF3, or e) â€”CN; wherein R2 is a) â€”H, b) â€”NO2, c) â€”Cl, d) CF3, or e) â€”CN; wherein R3 is a) â€”H, b) â€”C1-C5 alkyl, c) â€”Oâ€”C1-C5 alkyl, d) â€”OH, e) â€”NH2, f) â€”COOH, or g) â€”SH; or a pharmaceutically acceptable salt thereof; with the following proviso: 1) R1 and R2 are not both â€”H.