Patent ID: 6271247
Filing Date: 2001-08-07
Classification: A61P,C07C,C07D

Abstract:
A compound selected from those of formula (I):R--NH--A--CO--NH--NH--(W).sub.n --Z (I)wherein:n is 0 or 1,W represents --CO-- or S(O).sub.r wherein r is 0, 1 or 2,Z represents a group selected from optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl,R represents a group selected from:Z.sub.1 --T--CO--Z.sub.1 --O--T--CO--Z.sub.1 --T--O--CO--Z.sub.1 --T--S (O).sub.q --wherein:Z.sub.1 represents optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl,T represents a .sigma. bond, alkylene, alkenylene, or alkynylene,q represents 0, 1 or 2,when n=1A represents linear or branched alkylene having 3 to 8 carbon atoms, linear or branched alkenylene having 3 to 8 carbon atoms, linear or branched alkynylene having 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene, ##STR9##wherein B.sub.1 represents optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl, or A forms with the nitrogen atom a grouping ##STR10##when n=0A represents linear or branched alkenylene having 3 to 8 carbon atoms, linear or branched alkynylene having 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene, ##STR11##wherein B.sub.1 represents optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl, or A forms with the nitrogen atom a grouping ##STR12##wherein B.sub.2 represents saturated or unsaturated mono- or bicyclic system having 5 to 11 ring members, optionally containing 1 to 3 additional hetero atoms selected from nitrogen, oxygen and sulphur,with the proviso that when simultaneously n is 0, A represents ##STR13##B.sub.1 being benzyl,and Z represents optionally substituted phenyl, then R is other than benzoyl,at least one of R, Z, and A being or containing a heterocycle, heteroaryl, or heteroarylalkyl, their enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base,it being understood that:at least one of R, Z, and A being or containing a heterocycle, heteroaryl, or heteroarylalkyl,the term ""alkyl"" denotes a linear or branched group having 1 to 6 carbon atoms,the term ""alkylenene"" denotes a linear or branched bivalent radical containing 1 to 6 carbon atoms, unless indicated otherwise,the term ""alkenylene"" denotes a linear or branched bivalent radical containing from 2 to 6 carbon atoms and 1 to 3 double bonds, unless indicated otherwise,the term `alkynylene"" denotes a linear or branched bivalent radical containing 2 to 6 carbon atoms and 1 to 3 triple bonds, unless indicated otherwise,the term ""aryl"" denotes phenyl, naphthyl, dihydronaphthyl or tetrahydronaphthyl, and the term ""arylene"" denotes a bivalent radical of the same type, the term ""heteroaryl"" denotes an unsaturated or partially unsaturated mono- or bi-cyclic group having 5 to 11 ring members, containing 1 to 4 hetero atoms selected from nitrogen, oxygen, and sulphur,the term ""alkylenecycloalkylene"" represents --A.sub.1 --A.sub.2 --, the term ""cycloalkylene-alkylene"" represents --A.sub.2 --A.sub.1 --, and the term ""alkylenecycloalkylenealkylene"" represents --A.sub.1 --A.sub.2 --A.sub.1, the term ""alkylenearylene"" represents --A.sub.1 --A.sub.3 --, the term ""arylenealkylene"" represents --A.sub.3 --A.sub.1 --, the term ""alkylenearylenealkylene"" represents --A.sub.1 --A.sub.3 --A.sub.1 --, wherein A.sub.1 is alkylene as defined hereinbefore, A.sub.2 is (C.sub.4 -C.sub.8)cycloalkylene, and A.sub.3 is arylene as defined hereinbefore,the expression ""optionally substituted"" applied to the terms ""aryl"", ""arylalkyl"", ""heteroaryl"" and ""heteroarylalkyl"" indicates that those groups are substituted on their cyclic moiety by 1 to 5 identical or different substituents selected from linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, halogen, hydroxy, perhalo-(C.sub.1 -C.sub.6)alkyl in which the alkyl moiety is linear or branched, nitro, linear or branched (C.sub.1 -C.sub.6)acyl, linear or branched (C.sub.1 -C.sub.6)alkylsulphonyl, and amino (amino optionally being substituted by one or two linear or branched (C.sub.1 -C.sub.6)alkyl and/or linear or branched (C.sub.1 -C.sub.6)acyl).