Patent ID: 6057317
Filing Date: 2000-05-02
Classification: A61P,C07D

Abstract:
A compound selected from those of formula (I): ##STR35## wherein: n is 0 or 1,Y represents oxygen, sulphur, or CH.sub.2 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, each represent hydrogen, halogen, (C.sub.3 -C.sub.7)cycloalkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxy, linear or branched (C.sub.1 -C.sub.6) hydroxyalkyl, linear or branched (C.sub.1 -C.sub.6)trihaloalkyl, linear or branched (C.sub.1 -C.sub.6)alkyl-carbonyl, formyl, cyano, carboxy, linear or branched (C.sub.1 -C.sub.6)alkoxy-carbonyl, nitro, or optionally-substituted amino,or, (R.sub.1 -R.sub.2) or (R.sub.2 -R.sub.3) or (R.sub.3 -R.sub.4) form with the carbon atoms bearing them an optionally-substituted saturated or unsaturated 5- or 6-member ring, at most three of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 representing hydrogen,R.sub.5 represents hydrogen, (C.sub.3 -C.sub.7)cycloalkyl or linear or branched (C.sub.1 -C.sub.6)alkyl optionally substituted by a C.sub.3 -C.sub.7)cycloalkyl group, and optionally substituted phenyl,or, with R.sub.4, forms a saturated or unsaturated 5-, 6-, or 7-member ring optionally substituted by one or more identical or different groups selected from: linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxy, oxo, and optionally-substituted amino,R.sub.6 and R.sub.7 each represent hydrogen, or together form an oxo group,R.sub.8 represents halogen, hydrogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkenyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)alkoxy optionally substituted by amino, pyrrolyl or piperidinyl, (C.sub.3 -C.sub.7)cycloalkyloxy, optionally-substituted phenyloxy, or optionally-substituted benzyloxy;or, with R.sub.7, forms a bond,their N-oxides, their enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.