Patent ID: 6900232
Filing Date: 2005-05-31
Classification: A61P,C07D

Abstract:
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein is a 4-8 membered monocyclic ring or 7-12 membered bicyclic ring; which ring is optionally saturated or unsaturated, which ring is optionally substituted with one or more substituent selected from the group consisting of alkyl, haloalkyl, aryl, heteroaryl, halogen, alkoxyalkyl, aminoalkyl, hydroxy, nitro, alkoxy, hydroxyalkyl, thioalkyl, amino, alkylamino, arylamino, alkylsulfonamide, acyl, acylamino, alkylsulfone, sulfonamide, allyl, alkenyl, methylenedioxy, ethylenedioxy, alkynyl, carboxamide, cyano, and —(CH 2 ) m COR; m is 0 to 2; R is hydroxy, alkoxy, alkyl or amino; A optionally substituted by one or more R k selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino, alkylamino, halogen, acylamino, sulfonamide and —COR; R is hydroxy, alkoxy, alkyl or amino; with respect to z and NRk; at the para or meta position relative to the X substituent; n is 0 to 2; R X R R q is 0 or 1; with respect to X, X forms a cycloalkyl, optionally substituted with one or more substituent selected from the group consisting of alkyl, halogen, cyano, carboalkoxy, haloalkyl, alkoxyalkyl, alkylsulfone, aryl, heteroaryl, aralkyl, heteroaralkyl, or alkoxy; and