Patent ID: 6261554
Filing Date: 2001-07-17
Classification: A61K,B82Y,C07K,C12N

Abstract:
A targeting gene delivery vehicle complex, said targeting gene delivery vehicle complex comprising:a gene delivery vehicle coupled with a bispecific conjugate, said gene delivery vehicle comprising:an expressible recombinant nucleic acid molecule encoding a gene product of interest;a capsid or an envelope having an exterior, said capsid or envelope enveloping said recombinant nucleic acid molecule; anda first member of a specific binding pair associated with said capsid or envelope exterior, which member of said specific binding pair is not directly associated with a surface of a target cell and wherein said first member of the specific binding pair is naturally or recombinantly expressed on said capsid or envelope exterior;wherein said bispecific conjugate comprises a second member of said specific binding pair covalently coupled to a targeting moiety capable of binding to a target molecule associated with the surface of the target cell.