Patent ID: 6831174
Filing Date: 2004-12-14
Classification: C07D

Abstract:
A process comprising:reacting a mercaptoacetaldehyde with a compound of formula RyOOCCHO, wherein Ry is C1-12 alkyl or C6-20 aryl to obtain a compound of formula (XV) converting the hydroxyl group of the compound of formula (XV) to a leaving group L to obtain a compound of formula (XVI): reacting the compound of formula (XVI) with a silylated R2-compound, in the presence of a Lewis acid, whereby said leaving group is displaced, to produce a compound of formula (XVII): whereinZ is S; R2 is selected from the following group: X is oxygen or sulfur; Y is oxygen or sulfur; R3 and R4 are independently selected from hydrogen, hydroxyl, amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-10 acyl or aracyl; and R5 and R6 are independently selected hydrogen, halogen, hydroxyl, amino, cyano, carboxy, carbamoyl, alkoxycarbonyl, hydroxymethyl, trifluoromethyl, thioaryl, C1-6 alkyl, C2-6 alkenyl, C1-6 alkynyl, and C1-10 acyloxy.