Patent ID: 8623418
Filing Date: 2014-01-07
Classification: A61K

Abstract:
1. A method of treating moderate to severe chronic pain in a patient in need thereof comprising orally administering to the patient an intact multi-layer pharmaceutical composition comprising: a core; an opioid antagonist layer, coating the core; a sequestering polymer layer which contains a charge-neutralizing additive and a hydrophobicity-enhancing additive and which coats said opioid antagonist layer; an opioid agonist layer coating the sequestering polymer layer, and; an osmotic pressure regulating agent located immediately beneath the agonist layer; wherein administration of the intact form of the composition to the patient once or twice daily for a time period of at least two weeks results in zero release of the antagonist over the time period as determined by the antagonist concentration in the plasma of the patient.