Patent ID: 6267966
Filing Date: 2001-07-31
Classification: A61K,A61P,C07K,Y10S

Abstract:
A recombinant microorganism which is able to express Bacillus anthracis protective antigen which is able to generate an immune response in a mammal which response is protective against Bacillus anthracis, said microorganism comprising a sequence which encodes PA wherein at least one of (i) a gene of said microorganism which encodes a catabolic repressor protein (CcpA) and/or a transition state regulator, AbrB, is inactivated, and/or (ii) a region of the said PA sequence which acts as a catabolic repressor biding site is mutated so that it is inactivated; and/or (iii) a region of said PA sequence which acts as an AbrB binding site is mutated so that it is inactivated.