Patent ID: 8519151
Filing Date: 2013-08-27
Classification: C07C,C07D

Abstract:
1. A process for the preparation of the compound of formula I which process comprises a) reacting a compound of formula II wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula III wherein X is chloro or bromo; reacting the halobenzyne of formula III so formed with a fulvene of formula IV to a compound of formula V wherein X is chloro or bromo; b) hydrogenating the compound of formula V in the presence of a suitable metal catalyst to a compound of formula VI wherein X is chloro or bromo; and either c1) reacting the compound of formula VI with NH and d) reacting the compound of formula VII in the presence of a base with a compound of formula VIII to the compound of formula I; or c2) reacting the compound of formula VI wherein X is chloro or bromo; in the presence of a solvent, a base, a copper catalyst and at least one ligand with the compound of formula VIIIa to the compound of formula I.