Patent ID: 6825220
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A compound of formula I: wherein:R1 is H, CN, halo, C1-C6 alkyl, C1-C4 haloalkyl, CO2R8, CONHR8, NHCOR8, NHR8, OR8, SR8, SOR8, SO2R8 or SO2NHR8; R1a is H, halo or C1-C6 alkyl; R2 and R3 combine with the carbon to which each are attached to form a C3-C7 carbocyclic ring; R4 is H or C1-C6 alkyl; R5 and R6 are independently H or C1-C6 alkyl; or R5and R6 combine with the carbon to which each are attached to form a C3-C6 carbocyclic ring; or R6 combines with X1, the carbon to which both are attached, and the phenyl group to which X1 is attached to form a moiety selected from the group consisting of: wherein: m and n are independently 0, 1, 2, or 3 provided that the sum of n+q is &lE;5 and that R5 is H; R7 is hydrogen, optionally substituted phenyl or optionally substituted heterocycle; R8 is H or C1-C6 alkyl; X is OCH2, SCH2 or a bond; and X1 is a bond or a C1-C5 divalent hydrocarbon moiety; and X2 is O, S, NH, NHSO2, SO2NH, CH2 or a bond; or a pharmaceutical salt thereof.