Patent ID: 6358982
Filing Date: 2002-03-19
Classification: A61P,C07D

Abstract:
A compound of the formula: wherein:R1 represents a carbon-linked 4 to 7 membered saturated heterocyclic ring containing as the hetero ring members a group NRa and a group Xa in which Xa represents CH2, CO, O, S or NRb; Ra represents hydrogen or (1-4C)alkyl; and Rb represents hydrogen or (1-4C)alkyl; L represents a bond or a group of formula â€”(La)mâ€”Xâ€”(Lb)nâ€” in which X represents O, S, NRc, CONH or NHCO; La represents (1-4C)alkylene; Lb represents (1-4C)alkylene; m is zero or 1; n is zero or 1; and Rc is hydrogen or (1-4C)alkyl; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either (a) one or two of R5, R6, R7 and R8 represents hydrogen; (1-6C)alkyl; aryl(1-6C)alkyl; (2-6C)alkenyl; aryl (2-6C)alkenyl or aryl, or (b) two of R5, R6, R7 and R8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R5, R6, R7 and R8 represent hydrogen; or a pharmaceutically acceptable salt thereof, provided that when L represents a group of formula â€”(La)mâ€”Xâ€”(Lb)nâ€” and m is 0, R1 is not pyrrolidinyl.