Patent ID: 9035024
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method of treating breast cancer, the method comprising: selecting a subject diagnosed as having breast cancer associated with overexpression of Survivin; and administering to the selected subject a therapeutically effective amount of a pharmaceutical composition comprising a compound: (i) consisting of a D-amino acid peptide selected from the group consisting of: (D-Leu)-(D-Phe)-(D-Ala)-(D-Cys)-(D-Gly)-(D-Ser)-(D-Ser)-(D-His)-(D-Lys); (D-Cys)-(D-Gly)-(D-Ser)-(D-Ser)-(D-His); and (D-Gly)-(D-Ser)-(D-Ser)-(D-His)-(D-Lys); or (ii) comprising the formula X-A or A-X, wherein A consists of a D-amino acid sequence selected from the group consisting of: (D-Leu)-(D-Phe)-(D-Ala)-(D-Cys)-(D-Gly)-(D-Ser)-(D-Ser)-(D-His)-(D-Lys); (D-Cys)-(D-Gly)-(D-Ser)-(D-Ser)-(D-His); and (D-Gly)-(D-Ser)-(D-Ser)-(D-His)-(D-Lys); and X consists of an internalization peptide sequence of a protein selected from the group consisting of: Tat, Antennapedia, VP22, Pep-1, and transportan, or a retro-inverso version of said internalization peptide sequence.