Patent ID: 6358512
Filing Date: 2002-03-19
Classification: A61K,A61P,C07K,C12N,G16H,Y02A

Abstract:
A modified spike or spicule (S) polypeptide expressed by the nucleotide sequence of the feline infectious peritonitis virus (FIPV) S gene having the nucleotide sequence of the 79-1146 FIPV strain S gene modified in a codon selected from the group consisting of:(i) the codon coding for Asp at position 568; (ii) the codon coding for Asp at position 591; (iii) the codon coding for Asp at position 643; (iv) the codon coding for Arg at position 649; and (v) the codon coding for Arg at position 656; said modification being such that the modified S protein expressed by said modified sequence no longer induces enhancing antibodies.