Patent ID: 6525202
Filing Date: 2003-02-25
Classification: A61P,C07D

Abstract:
A compound of formula I having the structure whereinA is Ar; X is a bond; T1 is (CH2)m; T2 is (CH2)n; T is a bond; R1, R2, and R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, hydroxy, halogen, trifluoromethyl, alkoxy of 1-6 carbon atoms, benzyloxy, allyloxy, propargyloxy, acyloxy of 2-7 carbon atoms, cyano, nitro, amino, aminocarbonyl, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, formamido, ureido, acylamino of 2-7 carbon atoms, alkylsulfonylamino of 1-6 carbon atoms, arylsulfonylamino, dialkyloxyphosphorylamino of 1-6 carbon atoms per alkyl group, dihydroxyphosphorylamino, â€”CO2-alkyl of 1-6 carbon atoms, or Ar optionally substituted with R11; R4 is hydrogen, alkyl of 1-6 carbon atoms, halogen, hydroxy, alkyoxy of 1-6 carbon atoms, alkylthio of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, carboxy, acyl of 2-7 carbon atoms, ArCOâ€”, alkoxycarbonyl of 2-7 carbon atoms, aminocarbonyl, alkylaminocarbonyl of 2-7 carbon atoms, alkylsulfonyl of 1-6 carbon atoms, or alkylsulfonylamino of 1-6 carbon atoms, R5 is Aa is (i) an amino acid, wherein the nitrogen of amino acid attached to the adjacent carbonyl of R5; or (ii) an alkyl ester of an amino acid, wherein the nitrogen of amino acid attached to the adjacent carbonyl of R5, and the alkyl moiety of the alkyl ester contains 1-6 carbon atoms; Y and Z are each, independently, NR7, O, or S; X1 and X2 are each, independently, CO or SO2; a dotted line represents and optional double bond; R6, and R7 are each, independently, hydrogen; alkyl of 1-6 carbon atoms optionally substituted by R11, R12, and R13; alkenyl of 2-7 carbon atoms optionally substituted by R11, R12, and R13; alkynyl of 2-7 carbon atoms optionally substituted with R11; cycloalkyl of 3-8 carbon atoms optionally substituted by R11, R12, and R13; bicycloalkyl of 7-11 carbon atoms optionally substituted by R11, R12, and R13; â€”CO2-alkyl of 1-6 carbon atoms; or Ar optionally substituted by R11, R12, and R13; R11, R12, or R13 are each, independently, alkyl of 1-6 carbon atoms, halogen, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, cycloalkyl of 3-8 carbon atoms, Ar-alkyl having 1-6 carbon atoms in the alkyl moiety, Ar optionally substituted with R14, hydroxy, alkoxy of 1-6 carbon atoms, Ar-oxy, oxo, â€”CN, â€”CHO, â€”CO2H, â€”OCO2-alkyl of 1-6 carbon atoms, â€”CO2-alkyl of 1-6 carbon atoms, â€”CO2â€”Ar, â€”CO2-alkyl-Ar wherein the alkyl moiety has 1-6 carbon atoms, â€”OCO2â€”Ar, â€”CONH2, â€”CONHOH, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, â€”NHCONH-alkyl of 1-6 carbon atoms, -NHSO2-alkyl of 1-6 carbon atoms, â€”NHSO2-Ar, or when R11 and R12 are contained on a common carbon atom of an alkyl moiety, they may be taken together to form a spiro cycloalkyl ring of 3-8 carbon atoms; R14 is halogen, alkoxy of 1-6 carbon atoms, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, hydroxy, acyl of 2-7 carbon atoms, â€”SO2-alkyl of 1-6 carbon atoms, CO2-alkyl of 1-6 carbon atoms, or alkoxycarbonylalkyl of 3-13 carbon atoms; Ar is an aromatic ring system containing 1-2 carbocyclic aromatic rings having 6-10 carbon atoms; m=2; n=2; or a pharmaceutically acceptable salt thereof.