Patent ID: 9044484
Filing Date: 2015-06-02
Classification: A61K,A61P

Abstract:
1. A multi-dose ophthalmic composition, comprising: a therapeutically effective amount of brimonidine; a first polyol, the first polyol being selected from mannitol, sorbitol or a combination thereof wherein the concentration of the first polyol in the composition is at least 0.15 w/v % but is less than 0.5 w/v %; a second polyol, the second polyol being selected from propylene glycol, glycerine or a combination thereof wherein the concentration of the second polyol in the composition is at least 0.3 w/v % but less than 1.2 w/v % of the composition; borate in the composition at a concentration that is at least 0.1 w/v % but less than about 0.5 w/v %; BAC as an anti-microbial preservative, the concentration of BAC in the composition being greater than 0.0007 w/v % but less than 0.0035 w/v %; and water; wherein the composition has a pH that is at least 4 but less than 7.0.