Patent ID: 7514095
Filing Date: 2009-04-07
Classification: A61B,A61K,A61L,A61P,D01F,D06M,Y10T

Abstract:
1. A method of fabricating fibers with a linear gradient of biomolecules, said method comprising: a) obtaining a first polymer solution comprising a first biodegradable polymer at a concentration between 5 to 30 wt % and a first solvent, and a second polymer solution comprising a second biodegradable polymer; and b) mixing said first polymer solution and said second polymer solution in a continuously changing ratio to obtain a mixture of said first and second polymer solutions, while extruding said mixture into a coagulating bath, wherein the coagulating bath comprises a second solvent that is miscible with the first solvent and is a non-solvent for the first and second polymers, and wherein at least one of said first polymer solution and said second polymer solution is a surfactant stabilized water-in-oil type emulsion of an aqueous phase comprising a biomolecule of interest.