Patent ID: 6982335
Filing Date: 2006-01-03
Classification: A61P,C07B,C07C,C07D

Abstract:
1. A method of preparing an alkylated thiazoline carboxylic acid or a derivative thereof represented by Structural Formula (I): or a salt thereof, wherein R 1 is a substituted or unsubstituted alkyl group; each R R n is an integer from 1 to 5, the method comprising: (a) coupling a compound represented by Structural Formula (II):  wherein each R  with a cysteine ester represented by Structural Formula (III):  thereby forming a substituted thiazoline carboxylic acid ester represented by Structural Formula (IV): (b) optionally, hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid represented by Structural Formula (V): (c) optionally, protecting the carboxyl group of the substituted thiazoline carboxylic acid to form a protected thiazoline carboxylic acid represented by Structural Formula (VI): (d) alkylating the optionally protected thiazoline carboxylic acid represented by Structural Formula (VII):  with a compound having the formula R (e) optionally, hydrolyzing the optionally protected alkylated thiazoline carboxylic acid and cleaving ether groups, thereby forming the compound represented by Structural Formula (I).