Patent ID: 9110061
Filing Date: 2015-08-18
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A method for detecting a Mycobacterium tuberculosis infection in a test subject, comprising: (A) incubating in vitro (i) a blood sample or a lavage sample that comprises lymphocytes from the test subject, with (ii) ESAT6 protein and CFP10 protein, and (iii) at least one of: wherein said step of incubating is for a time and under conditions sufficient for: (B) detecting a test level of the effector molecule that is produced by lymphocytes stimulated according to step (A), wherein the detected test level of the effector molecule is greater than a detectable effector molecule level that can be produced by said lymphocytes incubated only with said ESAT6 and CFP10 proteins, wherein if the test level of the effector molecule that is detected is higher than a control level of the effector molecule that is detected following incubation of control lymphocytes from a healthy control subject, then the test level indicates that the test subject is infected with, or has been previously exposed to,