Patent ID: 8530634
Filing Date: 2013-09-10
Classification: C07D,C07H

Abstract:
1. A method for linking a reporter moiety to an oligonucleotide, comprising: reacting a reporter moiety having an alkylazide group (Y—X—N wherein X is an aliphatic linker having a length of 1-20 atoms, where chain is comprised of carbon atoms, optionally substituted by one or more hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur; Y is reporter molecule; W is a chain of atoms having a length of 1-20 atoms, where chain is comprised of carbon atoms, optionally substituted by one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; Z is controlled pore glass (CPG), polystyrene, or oligonucleotide chain attached to solid support; and R