Patent ID: 6458790
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein Q is Z is O, S, or NR4b; each n is independently 0, 1, or 2; R1 is selected from the group consisting of hydrogen, C1-8 alkyl, (CHR7)nâ€”C3-6 cycloalkyl, (CHR7)nâ€”O(CHR7)aryl, (CHR7)n-aryl, and (CHR7)n-heteroaryl; in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; R2 is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)nC3-6 cycloalkyl, and (CH2)n-aryl; each R3 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)nC3-6 cycloalkyl, (CH2)n-heteroaryl, and (CH2)n-heterocyclyl; in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; R4a and R4b are each independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)nC3-6 cycloalkyl, (CH2)n-heteroaryl, (CH2)n-heterocyclyl, COC(R7)2NH2, COR7, (CH2)nOR7, (CH2)nCO2R7, CH2Câ‰¡CH, CO2R7, CH2CHF2, CONR7R7, and SO2R7; in which aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; R5a and R5b are each independently selected from the group consisting of hydrogen, C1-8 alkyl, C3-8 cycloalkyl, and (CH2)n-aryl; wherein alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; and aryl is unsubstituted or substituted with one to three groups independently selected from R6; R6 is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)nC3-7 cycloalkyl, (CH2)n-heteroaryl, halogen, OR7, NHSO2R7, N(R7)2, Câ‰¡N, CO2R7, C(R7)(R7)N(R7)2, NO2, SO2N(R7)2, S(O)0-2R7, CF3, and OCF3; or two R6 substituents, when on the same carbon atom, can be taken together together with the carbon atom to which they are attached to form a cyclopropyl group; each R7 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; each R8 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)n-heteroaryl, (CH2)n-heterocyclyl, and (CH2)nC3-7 cycloalkyl; wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, heterocyclyl, and (CH2)n are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; or two R8 groups together with the atoms to which they are attached form a 5- to 8-membered mono- or bi-cyclic ring system optionally having an additional heteroatom selected from O, S, NR7, NBoc, and NCbz; each R9 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, (CH2)nC3-6 cycloalkyl, (CH2)n-heteroaryl, halogen, OR7, NHSO2R7, N(R7)2, Câ‰¡N, CO2R7, C(R7)(R7)N(R7)2, NO2, SO2N(R7)2, S(O)0-2R7, CF3, and OCF3; X is selected from the group consisting of C1-8 alkyl, (CH2)nC3-8 cycloalkyl, (CH2)naryl, (CH2)nheteroaryl, (CH2)nheterocyclyl, (CH2)nCâ‰¡N, (CH2)nCONR8R8, (CH2)nCO2R8, (CH2)nCOR8 (CH2)nNR8C(O)R8, (CH2)nNR8CO2R8, (CH2)nNR8C(O)N(R8)2, (CH2)nNR8SO2R8, (CH2)nS(O)0-2R8, (CH2)nSO2N(R8)(R8), (CH2)nOR8, (CH2)nOC(O)R8, (CH2)nOC(O)OR8, (CH2)nOC(O)N(R8)2, (CH2)nN(R8)(R8), and (CH2)nNR8SO2N(R8)(R8); wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups selected from R6; and alkyl, (CH2)n, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; Y is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)nC3-8 cycloalkyl, (CH2)naryl, (CH2)nheterocyclyl, and (CH2)nheteroaryl; wherein aryl and heteroaryl are unsubstituted or substituted with one to three groups selected from R6; and alkyl, (CH2)n, cycloalkyl, and heterocyclyl are optionally substituted with one to three groups selected from R6 and oxo.