Patent ID: 7776919
Filing Date: 2010-08-17
Classification: A61P,C07C,C07D

Abstract:
1. A method for treating Alzheimer's disease by inhibiting a Receptor for Advanced Glycated Endproducts (RAGE) which comprises administering to a subject in need thereof a therapeutically effective amount of at least one RAGE inhibitor compound of Formula (I) wherein G G f) a group of the formula R R wherein m and n are independently selected from 1, 2, 3, or 4; X is a direct bond, CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—, -Q R R R wherein the aryl and/or alkyl group(s) in R R R or a pharmaceutically acceptable salt thereof, wherein a therapeutically effective amount comprises sufficient RAGE inhibitor compound to at least partially inhibit the binding of a ligand to the RAGE.