Patent ID: 7927795
Filing Date: 2011-04-19
Classification: A61P,C12Q,G01N,Y10S

Abstract:
1. A method of detecting ovarian serous papillary carcinoma in an individual, comprising the steps of: examining a tumor sample from said individual by the expression level of a group of genes consisting of LAMC2, CLDN4, CLDN3, TACSTD1, TFAP2A, KRT6E, CDKN2A, UGT2B7, L1CAM, TACSTD2, LAD1, KIBRA, HBP17, PAX8, CLDN7, LAMA3, S100A1, CDH6, LCN2, FOLR3, DEFB1, BIK, FGF18, LAMB3, S100A2, WNT7A, GAL, CD24, EPHAT, HDAC9, DUSP4, ERBB3, CELSR1, NMU, ANXA3, KLK10, TRIM29, SERPINB2, ITGB4, CCNA1, CDH1, IL1RN, DKK1, DSP, TNNT1, ERBB2, SPP1, BUB1B, KLK6, BMP7, TSPAN-1, IMP-3, LISCH7, HOXB2, TTK, FGFR2, TGFA, NUP210, NFE2L3, CCND1, SFN, SRCAP, CCNE1, KRT6E, MAP17, MKI67, CDC6, PRSSB, SPP1, ITPR3, UPK1B, SERPINB5, TOP2A, CA2, KRT7, PLS1, MAL, KIF11, PITX1, ARHGAP8, TRIM16, HOXB5, PKP3, CXADR, TFAP2C, FGFR3, MAPK13, ITGA3, STHM, DUSP10, RAI3, TPX2, DHCR24, MGC29643, MUC1, JUP, SLPI, CDC2; HMMR, PTPRR, LMNB1, C14orf78, CD47, C16orf34, ST14, CDKN3, MCM4, VAMP8, TNFAIP2, FOXM1, SPINT1, MKI67, UBE2C, GPR56, RAU, ZNF339, ITPR3, and EFNA1; and performing hierarchical cluster analysis on the expression levels of said genes as compared to those in normal individual, wherein over-expression of said genes indicates that said individual has ovarian serous papillary carcinoma.