Patent ID: 8435959
Filing Date: 2013-05-07
Classification: A61K,A61P,C07H

Abstract:
1. A method for identifying and treating a patient having a tumor or cancer cell with enhanced sensitivity to triciribine (TCN) comprising: (a) determining whether a patient has a tumor or cancer cell with enhanced sensitivity to triciribine comprising: wherein a 1.5 fold greater expression of Akt in the tumor or cancer cell compared to a control tissue is indicative of a patient having a tumor or cancer cell with enhanced sensitivity to triciribine; and (b) administering to the patient having a tumor or cancer cell with enhanced sensitivity to triciribine at least one compound of the formula: wherein said treatment comprises administering 45 mg/m 2 or less of at least one compound over a one-hour intravenous infusion on days 1, 8, and 15 every 28 days until regression of the tumor or cancer cell is evident.