Patent ID: 6645998
Filing Date: 2003-11-11
Classification: A61P,C07D

Abstract:
A method for the treatment of a cell proliferative disease comprising administering to an animal a pharmacologically effective dose of a compound having a structural formula: wherein X is oxygen; R1 is â€”C1-10 alkylene-COOH â€”C1-4 alkylene-CONH2, â€”C1-4 alkylene-COOâ€”C1-4 alkyl, â€”C1-4 alkylene-CON(C1-4 alkylene-COOH)2, C1-4 alkylene-OH, C1-4alkylene-NH3-halo, or C1-4 alkylene-OSO2NH(C1-4 alkyl)3; R2, R3 are H or C1-4 alkyl; R4 is C1-4 alkyl; and R5 is methyl, C7-17 alkyl, COOH, C7-17 olefinic group containing 3 to 5 ethylenic bonds, â€”C&boxH;Câ€”COOâ€”C1-4 alkyl or C1-4 alkylene-COOâ€”C1-4 alkyl with the proviso that R1 cannot be â€”C2-4 alkylene-COOH when R2, R3, and R4 are methyl, and R5 is a C16 alkyl; or a pharmaceutical composition thereof.