Patent ID: 8435528
Filing Date: 2013-05-07
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a tumor comprising administering to a subject in need of treatment an effective amount of a maytansinoid-cell-binding agent conjugate or a pharmaceutically acceptable salt or solvate thereof, wherein the maytansinoid-cell-binding agent conjugate comprises at least one maytansinoid linked to the cell-binding agent, wherein the maytansinoid is represented by formula (II-L), (II-D) or (II-D, L): wherein: Y R R l, m and n are each independently an integer of from 1 to 5, and in addition n can be 0; and May represents a maytansinoid which bears the side chain at C-3, C-14 hydroxymethyl, C-15 hydroxy or C-20 desmethyl.