Patent ID: 6030973
Filing Date: 2000-02-29
Classification: C07D

Abstract:
A compound of formula (I) ##STR62## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein X represents O or S; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different and represent hydrogen, halogen, hydroxy, cyano, nitro; or optionally substituted groups selected from alkyl, (C.sub.3 -C.sub.6)cycloalkyl, alkoxy, (C.sub.3 -C.sub.6)cycloalkyloxy, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl selected from aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl or piperazinyl; aryloxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylamino, arylamino, amino, aminoalkyl, hydroxyalkyl, alkoxyalkyl, thioalkyl, alkylthio, acyl, acylamino, aryloxycarbonylamino, aralkoxycarbonylamino, alkoxycarbonylamino, carboxylic acid or its derivatives, acyloxy, sulfonic acid or its derivatives; W represents a group NR.sup.9 ; R.sup.6 and R.sup.9 are the same or different and represent hydrogen; or optionally substituted groups selected from alkyl, (C.sub.3 -C.sub.6)cycloalkyl, aryl; aralkyl, heterocyclyl selected from aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl, or piperazinyl; heteroaryl, heteroaralkyl, acyl, hydroxyalkyl, aminoalkyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, alkylthio, or thioalkyl groups; R.sup.5 represents hydrogen, hydroxy or halogen or optionally substituted groups selected from alkyl, aryl, heteroaryl, acyl, alkoxy, aralkyl, or aralkoxy; n is an integer ranging from 1-4; Ar represents an optionally substituted divalent aromatic or heterocyclic group, R.sup.7 and R.sup.8 are the same or different and individually represent hydrogen, halogen, hydroxy, lower alkyl, optionally substituted aralkyl, or together form a bond; and B represents an oxygen atom or a sulfur atom.