Patent ID: 6589952
Filing Date: 2003-07-08
Classification: A61P,C07D

Abstract:
A compound of the Formula I: wherein: X is CHR5, NR5, O, S, S(O)n or a single bond, wherein n is equal to 0, 1 or 2; D is aryl or heteroaryl attached through an unsaturated carbon atom and wherein said aryl or heteroaryl is optionally substituted at any available position with from 1-5 of A1, A2, A3, A4 and A5; A1, A2, A3, A4 and A5 are each independently H, C1-6 alkyl, C3-6 cycloalkyl, halo, C1-4 haloalkyl, cyano, nitro, â€”OR12, SH, â€”S(O)nR13, â€”COR12, â€”CO2R12, â€”OC(O)R13, â€”NR11COR12, â€”N(COR12)2, or â€”NR11CONR12R14, or wherein A1, A2, A3, A4 and A5 are each independently phenyl or phenyl substituted with from 1 to 4 of C1-3 alkyl, C1-3 alkoxy, halo, cyano, dimethylamino, CF3, C2F5, OCF3, SO2Me or acetyl; R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-8 cycloalkyl, C4-12 cycloalkylalkyl, NR6R7 or â€”C(R8)(R9)â€”Oâ€”R10; R2 is C1-4 alkyl or C3-8 cycloalkyl, each of which is optionally substituted with from 1-3 hydroxy, halogen or C1-4 alkoxy, or wherein when X is a bond, R2 is CN, CF3, or C2F5; R3 and R4 are independently H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-5 cycloalkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, halogen, CN, or NR6R7; R5 is H, C1-4 alkyl or C3-8 cycloalkyl; R6and R7 are each independently H, C1-4 alkyl, C1-4 haloalkyl, C2-8 alkoxyalkyl, C3-6 cycloalkyl, C4-12 cycloalkylalkyl, aryl, aryl(C1-4 alkyl)-, heteroaryl or heteroaryl(C1-4 alkyl)-; R8 and R9 are each independently H or C1-4 alkyl, or R8 and R9 are taken together as &boxH;CH2; R10 is H or C1-4 alkyl; R11 is H, C1-4 alkyl, C3-7 cycloalkyl, C4-12 cycloalkylalkyl, phenyl or benzyl, each phenyl or benzyl optionally substituted on the aryl moiety with 1-3 groups of C1-4 alkyl, halogen, C1-4 haloalkyl, nitro, C1-4 alkoxy, C1-4 haloalkoxy, or dimethylamino; and, R12, R13 and R14 are each independently H, C1-6 alkyl, C3-10 cycloalkyl, C4-16 cycloalkylalkyl or C1-4 haloalkyl.