Patent ID: 6265413
Filing Date: 2001-07-24
Classification: A61P,C07D,Y02P

Abstract:
A camptothecin compound of the formula I, or a pharmaceutically acceptable salt thereof ##STR18##wherein:R is hydrogen or -(CH.sub.2).sub.2 --NR.sub.1 R.sub.2, where R.sub.1 is hydrogen or an amino protecting group and R.sub.2 is a lower alkyl, hydroxyethyl or acetoxyethyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, form a cyclic moiety;n is 1 or 2; andR.sub.3 is hydrogen or -OR.sub.4, where R.sub.4 is hydrogen, COR.sub.5, CONHR.sub.6, or CH.sub.2 OR.sub.7, where R.sub.5 is methyl or CH.sub.3 OCH.sub.2 --, R.sub.6 is isopropyl, phenyl or --CH.sub.2 CH.sub.2 Cl and R.sub.7 is methyl, ethyl, or CH.sub.3 OCH.sub.2 CH.sub.2 --;with the provisos that:R and R.sub.3 cannot both be hydrogen;when n is 2 and R is --(CH.sub.2).sub.2 --N(Cbz)CH.sub.3, then R.sub.3 cannot be hydrogen;when n is 2 and R.sub.3 is OH, then R cannot be hydrogen; andwhen R is --CH.sub.2 CH.sub.2 NHCH.sub.3, then R.sub.3 cannot be hydrogen.