Patent ID: 6310053
Filing Date: 2001-10-30
Classification: A61K

Abstract:
A composition containing as active principle an amount of a tetracycline compound effective for antibiotic activity, either as the free base or a salt thereof with a physiologically acceptable acid, complexed with a substantially equimolar amount of a magnesium compound, solubilized in a water miscible solvent system comprising,a) glycerol formal in an amount of from about 10 to about 50% (v/v); withc) polyethylene glycol wherein,(i) when the polyethylene glycol hag a molecular weight of not more than about 200, the polyethylene glycol is present in an amount of from about 1% to about 2(0% (v/v);(ii) when the polyethylene glycol has a molecular weight of not more than about 400, the polyethylene glycol is present in an amount of from about 1% to about 15% (v/v);(iii) when the polyethylene glycol has about molecular weight of not more than about 6000, the polyethylene glycol is present in an amount of from about 1% to about 10% (v/v); and(iv) when the polyethylene glycol has a molecular weight of greater than about 6000, the polyethylene glycol is present in an amount of from about 1% to about 5% (v/v),said composition optionally containing a pH modifier in an amount sufficient to maintain a physiologically acceptable pH, the balance being made up with water q.s.