Patent ID: 9066882
Filing Date: 2015-06-30
Classification: A61K,A61Q,B01J,B82Y

Abstract:
1. A method for production of thermolabile nanoparticles from thermolabile biocompatible matrix material(s) selected from lipids, biopolymers, and proteins, optionally with therapeutic, cosmetic or protein active agents, comprising of the following steps: (a) atomizing a solution of the thermolabile, biocompatible matrix material(s) in aqueous or organic solvent(s), with said active agents, by mixing the solution with carrier gas using an atomizer to create droplets from the solution, wherein solute concentration in the solution ranges from 0.001 mg/ml to 10 mg/ml, (b) suspending said droplets in said carrier gas, wherein the carrier gas is selected from the group consisting of nitrogen gas or inert gas, (c) passing the droplets suspended in carrier gas from the atomizer to a pulse-heat zone of a pulse-heat aerosol reactor and subjecting said carrier gas with droplets, suspended therein, to pulse heating for controlled evaporation in the pulse-heat zone of the pulse-heat aerosol reactor to form a heated aerosol comprising the suspended nanoparticles and carrier gas under predetermined heat pulse of controlled magnitude and duration comprising exposing the suspended droplets to heating at a temperature in the range of 25° C. to 110° C. for a pulse duration between 0.1 to 1 seconds, to achieve control over nanoparticle properties, (d) passing the aerosol formed in step c) along with a gas stream line through a quenching zone to cool the aerosol containing the suspended nanoparticles formed in step c by dilution with cooling gas selected from nitrogen gas or an inert gas, to prevent prolonged heating and thermal damage, (e) collecting the nanoparticles produced.