Patent ID: 7045348
Filing Date: 2006-05-16
Classification: C07K,C12N

Abstract:
1. A targeted recombinant adenovirus vector, comprising: (i) a gene encoding a heterologous protein; (ii) a modified fiber protein comprising a first zipper peptide, wherein said first zipper peptide is capable of forming heteroduplex with a second zipper peptide via formation of coiled coils; and (iii) a gene encoding a fusion protein comprising said second zipper peptide and a targeting ligand, wherein binding of said first zipper peptide to said second zipper peptide connects said targeting ligand to said modified fiber protein, thereby targeting said adenovirus vector to a cell that expresses a cell surface molecule that binds to said targeting ligand, wherein said zipper peptides are selected from the group consisting of SEQ ID NOs: 1, 2, 3, and 4.