Patent ID: 7786314
Filing Date: 2010-08-31
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a compound of formula (IA): wherein R 1 and R 2 are each selected from the group consisting of (1) hydrogen, (2) C (3) C (4) —(CH wherein n is 1 or 2, and said alkyl, cycloalkyl and phenyl are unsubstituted or substituted with one or more halogen, hydroxy, C 1-6 alkyl or C 1-6 alkoxy; X is selected from the group consisting of (1) halogen, and (2) hydrogen; or pharmaceutically acceptable salts thereof, comprising: (A) oxidizing a compound of formula (II): wherein R 3 is selected from the group consisting of (1) —OH, (2) —O—R (3) —NR R wherein R p is 1 or 2; q is an integer selected from 1-10; and to form a compound of formula (IV): (B) deprotecting the compound of formula (IV) to form a compound of formula (V): (C) reacting the compound of formula (V) with a compound of formula (VI): wherein R 5 and R 6 are each independently selected from the group consisting of (1) C (2) C (3) (CH wherein m is 0, 1 or 2, and R 7 is selected from the group consisting of (1) hydrogen, and (2) Si—(R to give a compound of formula (VII): (D) oxidizing the compound of formula (VII) to give a compound of formula (VIII): (E) converting the compound of formula (VIII) to a compound of formula (IX): and (F) converting the compound of formula (IX) to the compound of formula (IA).