Patent ID: 8703713
Filing Date: 2014-04-22
Classification: A61K,A61P

Abstract:
1. A method of treating pancreatic cancer in a subject, comprising administering to said subject (i) and (ii); (i) one or more peptides selected from the group consisting of; (a) a peptide consisting of the amino acid sequence selected from the group consisting of RFVPDGNRI (SEQ ID NO: 1), VYSSEEAEL (SEQ ID NO: 2), GYRIYDVVL (SEQ ID NO: 3), SYMISYAGM (SEQ ID NO: 4), KWEFPRDRL (SEQ ID NO: 5), and DFLTLEHLI (SEQ ID NO: 6), (b) the peptide of (a), in which 1 or 2 amino acids are substituted, or added, and wherein said peptide has cytotoxic T cell inducibility; (c) the peptide of (b), wherein the second amino acid from the N-terminus is phenylalanine, tyrosine, methionine, or tryptophan; and (d) the peptide of (b) or (c), wherein the C-terminal amino acid is phenylalanine, leucine, isoleucine, tryptophan, or methionine (ii) one or more chemotherapeutic agents selected from the group consisting of gemcitabine, a pharmaceutically acceptable salt thereof, and a prodrug thereof.