Patent ID: 8343514
Filing Date: 2013-01-01
Classification: A61K,A61L,A61P,B82Y,C01B,C01G,C01P,Y10S

Abstract:
1. A sol-gel nanostructured titania reservoir in the form of a xerogel comprising silica, titania and silica-titania, obtained by the method comprising the steps of: i) putting in a three-necked flask a mixture consisting of 36 ml of deionized water; from 0 to 50 ml of ethylene diamine tetraacetic acid (EDTA) and 190 ml of tert-butanol; ii) adding HNO iii) adding 87 ml of titanium n-butoxide and 21.5 ml of tetraethoxysilane to the solution being refluxed to obtain a colloidal suspension; iv) refluxing the colloidal suspension for an additional period of 24 hours; v) drying the samples under vacuum conditions at 104 mm Hg in order to remove excess water and alcohol; and vi) drying the samples at 30° C. for 72 hours using an inert atmosphere furnace, increasing the temperature at a rate of 0.25° C/min in order to reach the final drying temperature of 30° C., wherein the pH is verified continually by means of a potentiometer during said refluxing; said reservoir having, if it comprises a drug, a constant rate of drug release over periods of 6 months to 3 years.