Patent ID: 6992100
Filing Date: 2006-01-31
Classification: A61K

Abstract:
1. A tetracyclic compound of formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein; E n is 1, 2 or 3 and y is an appropriate number of hydrogen atoms based on the value of (n) and also based on ring unsaturation; R wherein; R R and Z is selected from an amide, thioamide, oxime amide, oxime thioamide, glyoxylamide, hydrazide, ureido or acetamide group represented by the formulae, wherein X is oxygen or sulfur, R a and R a′ are independently selected from hydrogen, (C 1 –C 8 )alkyl, aryl, (C 1 –C 8 )alkaryl, (C 1 –C 8 )alkoxy, aralkyl and —CN; R or the group —(L wherein Y is oxygen; R 6a is selected from the group consisting of OH, (C 1 –C 6 )alkoxy, and aryloxy; and wherein R 6b is hydrogen or an organic substituent selected from the group consisting of (C 1 –C 8 )alkyl, aryl, (C 7 –C 14 )aralkyl, (C 7 –C 14 )alkaryl, (C 3 –C 8 )cycloalkyl, (C 1 –C 8 )alkoxyalkyl and these groups substituted with halogen, —CF 3 , —OH, (C 1 –C 8 )alkyl, amino, carbonyl, and —CN; or R wherein R 6c is selected from the group consisting of H, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, heteroaryl and aryl, —CF 3 ; and wherein NR 6d is an amino acid residue of an amino acid with the nitrogen atom being part of the amino group of the amino acid, R R