Patent ID: 7767390
Filing Date: 2010-08-03
Classification: C12Q

Abstract:
1. A method for detecting extracellular RNA from all or a portion of a drug-resistance-associated gene in blood plasma or serum from a human or animal with a neoplasm in the human or animal's brain for evaluating, monitoring, predicting, treating, or making a determination of drug-resistance in the brain neoplasm, the method comprising the steps of: a) extracting extracellular mammalian RNA from blood plasma or serum of a human or animal with a neoplasm in the brain; b) amplifying or signal amplifying a portion of the extracted RNA or cDNA prepared therefrom, wherein said fraction comprises extracellular RNA from a drug-resistance-associated gene, and wherein amplification is performed qualitatively or quantitatively using primers or probes specific for said RNA or cDNA to produce an amplified product or signal; and c) detecting the amplified product or signal.