Patent ID: 6433005
Filing Date: 2002-08-13
Classification: A61P,C07D

Abstract:
A compound selected from the group of compounds represented by Formula I whereinY is O or S; A is a â€”CH2â€”, â€”C(O)â€”, â€”Oâ€”, â€”Sâ€”, â€”S(O)â€”, or â€”S(O)2â€”; Ar is an optionally substituted phenyl; R1 is hydrogen, alkyl, alkoxy, hydroxy, halo, cyano, â€”C(O)NR4R5, â€”COOR4, â€”NR4R5, wherein R4 and R5 are each independently in each occurrence hydrogen or alkyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, halo, haloalkyl, nitro, cyano, or â€”NR4R5, wherein R4 and R5 are as defined previously; R3 is â€”SR6, â€”SOR6, â€”SO2R6, or â€”SO2NR4R5 wherein R6 is alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, or alkoxycarbonylalkyl; and R4 and R5 are as defined previously; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof.