Patent ID: 6258833
Filing Date: 2001-07-10
Classification: A61K,A61P,C07D,Y02A

Abstract:
A compound having a formula: ##STR168##wherein R.sup.1 is lower alkyl, bridged alkyl, aralkyl, cycloalkyl, a 5- or 6-membered saturated heterocycle, C.sub.1-3 alkylenecycloalkyl, aryl- or heteroaryl-substituted propargyl, aryl- or heteroaryl-substituted allyl, or halocycloalkyl;R.sup.2 is hydrogen, methyl, or halo-substituted methyl;R.sup.3 is C(.dbd.O)OR.sup.7 or C(.dbd.O)R.sup.7 ;R.sup.4 is hydrogen, lower alkyl, haloalkyl, cycloalkyl, or aryl;R.sup.8 is lower alkyl, alkynyl, haloalkyl, cycloalkyl, or aryl;R.sup.6 is hydrogen, lower alkyl, or C(.dbd.O)R.sup.7 ;R.sup.7 is lower alkyl, branched or unbranched, cycloalkyl, or aryl, either optionally substituted with one or more of R.sup.8 O, NR.sup.8 R.sup.9, or SR.sup.8 ; andR.sup.8 and R.sup.9, same or different, are selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, and aralkyl, or R.sup.8 and R.sup.9 together form a 4-membered to 7-membered ring;R.sup.10 is hydrogen, alkyl, haloalkyl, cycloalkyl, aryl, C(.dbd.O)alkyl, C(.dbd.O)cycloalkyl, C(.dbd.O)aryl, C(.dbd.O)O-alkyl, C(.dbd.O)Ocycloalkyl, C(.dbd.O)aryl, CH.sub.2 OH, CH.sub.2 Oalkyl, CHO, CN, NO.sub.2, or SO.sub.2 R.sup.11 ; andR.sup.11 is alkyl, cycloalkyl, trifluoromethyl, aryl, aralkyl, or NR.sup.8 R.sup.9.