Patent ID: 6200972
Filing Date: 2001-03-13
Classification: A61P,C07D

Abstract:
A non-immunosuppressive compound of formula I: ##STR7##or a pharmaceutically acceptable salt thereof, wherein:A and B, together with the nitrogen and carbon atoms to which they are respectively attached, form a 6 membered saturated or unsaturated heterocyclic ring containing, in addition to the nitrogen atom, one additional O, S, SO, or SO.sub.2 heteroatom in any chemically stable oxidation state;X is O or S;Z is O, NH or NR.sub.1 ;W and Y are independently O, S, CH.sub.2 or H.sub.2 ;R.sub.1 is C.sub.1 -C.sub.6 straight or branched chain alkyl or alkenyl, which is substituted in one or more position(s) with (Ar.sub.1).sub.n, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl connected by a C.sub.1 -C.sub.6 straight or branched chain alkyl or alkenyl, Ar.sub.2 ;n is 1 or 2;R.sub.2 is either C.sub.1 -C.sub.9 straight or branched chain alkyl or alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.7 cycloalkenyl, or Ar.sub.1, wherein said alkyl, alkenyl, cycloalkyl or cycloalkenyl is either unsubstituted or substituted in one or more position(s) with C.sub.1 -C.sub.4 straight or branched chain alkyl or alkenyl, hydroxyl, or a combination thereof; andAr.sub.1 and Ar.sub.2 are independently a mono-, bi- or tricyclic, carbo- or heterocyclic ring, wherein the ring is either unsubstituted or substituted in one to three position(s) with halo, hydroxyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 straight or branched chain alkyl or alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkenyloxy, phenoxy, benzyloxy, amino, or a combination thereof; wherein the individual ring sizes are 5-6 members; and wherein the heterocyclic ring contains 1-6 heteroatom(s) selected from the group consisting of O, N, S, and a combination thereof.