Patent ID: 8715341
Filing Date: 2014-05-06
Classification: A61F,A61K,A61L,A61P

Abstract:
1. An endovascular stent for placement at a vascular injury site, for inhibiting restenosis at the site, comprising a body having an open-lattice structure formed of linked filaments said filaments having outside, side and inside surfaces, and carried on the one or more filaments a drug-release coating having a thickness of between 3-30 microns, wherein the coating is applied as a fluid to the outside surfaces but not on the inside surfaces of said filaments, wherein the inside surfaces are free of any coatings; and the coating is composed of (i) a poly-lactide polymer substrate and (ii) a macrocyclic triene compound having the form: where R is CH 2 —CH 2 —OH or H, said stent being expandable from a contracted condition in which the stent can be delivered to a vascular injury site via catheter, and an expanded condition in which the stent coating can be placed in contact with the vessel at the injury site, said coating being effective to release an amount of the compound to inhibit restenosis at the site.