Patent ID: 9173885
Filing Date: 2015-11-03
Classification: A61K,A61P,C07D

Abstract:
1. A method of treatment of a disease selected from the group consisting: inflammatory host responses, impaired humoral and cell-mediated immune responses, leukocyte adhesion and migration processes in the endothelium, multiple sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy, mild cognitive impairment, Alzheimer's disease, Familial British Dementia, Familial Danish Dementia, neurodegeneration in Down Syndrome, Huntington's disease, rheumatoid arthritis, atherosclerosis, pancreatitis and restenosis, which comprises administering to a subject an effective amount of a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I), wherein said compound of formula (I) is the compound: or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: (a) R in which any of aforesaid heteroaryl groups may optionally be substituted by one or more groups selected from C in which any of aforesaid carbocyclyl groups may optionally be substituted by one or more groups selected from C (b) R (c) R (d) X and Z are independently selected as follows, (e) X and Z are jointly selected to represent two adjacent carbon atoms of a phenyl ring which is fused in that position and which is optionally substituted by one or more halogen or C (f) Y represents CHR wherein,