Patent ID: 8785602
Filing Date: 2014-07-22
Classification: C07K

Abstract:
1. An isolated antibody that competes for binding to the extracellular loop of a human Epithelial Membrane Protein2 (EMP2) (SEQ ID NO:42) with an EMP2 inhibitor, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises three heavy chain complementary determining regions (HCDRs) and wherein the light chain variable region comprises three light chain variable regions (LCDRs), wherein: the sequence of HCDR1 is SEQ ID NO:14, the sequence of HCDR2 is SEQ ID NO:16, the sequence of HCDR3 is SEQ ID NO:37, the sequence of LCDR1 is SEQ ID NO:19, the sequence of LCDR2 is SEQ ID NO:22, and the sequence of LCDR3 is SEQ ID NO:38.