Patent ID: 6716851
Filing Date: 2004-04-06
Classification: A61K,C07D

Abstract:
A compound selected from the group consisting of:4-(3-Methoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4(4Methoxyanilino)-6-methyl-2(2pyridinyl)pyrimidine; 4-(3-Fluoroanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Methylanilino)-6-methyl-2-(2pyridinyl)pyrimidine; 4-(4-Methoxyanilino)-2(3methylphenyl)-6-(methoxyethyl)pyrimidine; 4-(3-Benzyloxyanilino)-6methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Ethoxyanilino)-6-methyl-2-(2pyridinyl)pyrimidine; 4-(3 Cyanoanilino)-6-methyl-2-(2pyridinyl)pyrimidine; 4-(3-Acetophenonanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Methoxyanilino)-2-(3-methylphenyl)-6(methoxymethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-(Trifluoromethyl)anilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Acetoanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Nitroanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-(Trifluoromethoxy)anilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-(Methylthio)anilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Dimethylaminoanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Isopropylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine; 4-(3-Methoxy-phenoxy)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Methoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-5-methoxy-2-(2-pyridinyl)pyrimidine; 4-(3-Methoxyanilino)-6-(methoxymethyl)-2-(2-methyl-1-3-thiazol-4-yl)pyrimidine; 4-(2,5-Dimethoxyanilino)-6-(methoxymethyl)-2-(2-methyl-1-3-thiazol-4-yl)pyrimidine; 6-Morpholino-4-(3-methoxyanilino)-2-phenyl-pyrimidine; 6-Morpholino-4-(2,5-dimethoxyanilino)-2-phenyl-4-pyrimidine; 4-(2-Chloro-5-methoxyanilino)-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine; 4-[3-(4-Bromo-1-methyl-1H-pyrazol-3-yl)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(2-Methyl-pyrimidin-4-yl)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Phenylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(3-Nitrophenyl)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(2,3,4,5,6-Pentafluorophenoxy)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(2-Ethyl-1-phenyl-pyrazolin-5-one-3-yl)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(Phenylsulfone)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-(N-phenylamide)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Hydroxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(3,4-Methylenedioxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,4-Methylenedioxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,4-Methylenedioxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Methoxyanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(3-Methoxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,4-Dimethoxyanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(3,4-Dimethoxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,4-Methylenedioxyanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-(3,4-Methylenedioxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Methoxy-5-phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine 4-[2-Methyl-5-(carboxymethylester)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Methoxy-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Fluoro-2-methylanhlino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Methyl-5-trifluoromethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Methyl-5-nitroanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Amino-2-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(3-Ethoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Ethylanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5Methoxy-2-methylanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4(2Chloro-5-methoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4(3Methylmercaptoanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3 Hydroxyanilino)-2-(3-pyridinyl)-6(trifluoromethyl)pyrimidine hydrochloride; 4(3Hydroxyanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(3-Hydroxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2,4-Dimethoxyanilino)-6-methyl-2-(2-pyridinyl)-pyrimidine hydrochloride; 4-(3,5-Dimethoxyanilino)-6-methyl-2-(2-pyridinyl)-pyrimidine hydrochloride; 4-(2,5-Diethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Carboxyl-2-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(3-Methoxybenzylamino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Carboxyl-2-hydroxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-hydroxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-hydroxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,6-Dimethylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Methoxyanilino)-2,6-di(2-pyridinyl)pyrimidine; 4-(2,5-Dimethoxyanilino)-2,6-di(2-pyridinyl)pyrimidine; 4-(5-Methoxy-2-methylanilino)-2,6-di(2-pyridiflyl)pyrimidine; 4-(2-Methoxy-5-methylanilino)-2,6-di(2-pyridinyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2,6-di(2-pyridinyl)pyrimidine; 4-(2,5-Dimethylanilino)-2,6-di(2-pyridinyl)pyrimidine; 4-(2,5 Dimethylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2Methoxy-5-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4(5Hydroxy-2-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5 Hydroxy-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Methoxy-2-piperidino-anilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Cyano-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,5-Dimethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3,5-Dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2-Chloro-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(3-Methoxy-5-trifluoromethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-[6-(trifluoromethyl)-3-pyridinyl]-6-(trifluoromethyl)pyrimidine; 4-(5-Bromo-2-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Bromo-5-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-[3-Methyl-5-(trifluoromethyl)anilino]-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Chloro-2-hydroxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(4-Chloro-2,5-dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2-Chloro-5-methoxyanilino)-2-morpholino-6-(methyl)pyrimidine; 4-(2,4-Dichloro-5-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(Indol-4-ylamino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Acetyl-4,5-dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Methyl-5-nitroanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(5-Amino-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; N-[4-Methyl-3-(2-pyridin-3-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; 4-(2,5-Diethoxy-4-morpholinoanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-Methyl-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; N-[4-Methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]nicotinamide; 6-Chloro-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]nicotinamide; N-[4-Methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]-4-morpholino-benzamide; 4-Chloro-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; 4-Methoxy-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; 4-Chloromethyl-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; 4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]benzamide; 4-(2,5-Dimethyl-4-hydroxy-anilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2,5-Dimethyl-4-hydroxy-anilino)-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2,5-Dimethyl-4-hydroxy-anilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(4-Chloro-2,5-dimethoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(4-Chloro-2,5-dimethoxyanilino)-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(4,5-Dimethoxy-2-methylanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(4,5-Dimethoxy-2-methylanilino)-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(4,5-Dimethoxy-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2-Chloro-5-methoxyanilino)-6-methyl-2-aminopyrimidine; 4-(3Trifluoromethoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(4,5Dimethoxy-2-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine 4-(4-Chloro-2,5-dimethoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(2-Hydroxy-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(N-Methyl-3-methoxy-anilino)-2-(2-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(3,5-Dimethoxy-anilino)-2-(4-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(5-Chloro-2-methoxy-anilino)-2-(4-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(3,5-Dimethoxy-anilino)-2-(2,6-dichloro-4-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(2-Chloro-5-methoxy-anilino)-2-(2,6-dichloro-4-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(2-Methoxy-5-methyl-4-nitro-anilino)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(Indol-5-ylamino)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(5-Methoxy-2-methyl-4-nitro-anilino)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(3-Trifluoromethyl-1-pyrazolyl)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(4,5-Dihydro-2-thiazolyl-amino)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(1-Pyrazolyl)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(4,5,6,7-Tetrahydro-indazol-1-yl)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 4-(1H-3-Pyrazolyl-amino)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine; 6-Methyl-2-(2-pyridinyl)-4-(3-trifloromethylbenzylamino)-pyrimidine; 6-Methyl-4-(3-phenoxyanilino)-2-(2-pyridinyl)pyrimidine; 4-(3-Chloroanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3,4-Dimethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(4-Fluoro-3-methoxy-anilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3-Isopropoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine; 4-(3,4-Dimethoxyanilino)-6-trifluoromethyl-2-(2-pyridinyl)pyrimidine; 4-(5-Chloro-2-methoxy-anilino)-2-(4-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Methoxy-5-nitroanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Methoxy-2-nitro-anilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(3,5-Dimethoxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Carboxy-2-methoxy-anilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Hydroxy-2-nitro-anilino)-2-(3-pyridinyl)-6-trifluoromethylpynmidine; 4-(2-Ethanesulfonyl-5-hydroxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(2-Methoxy-5-methylanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Hydroxy-2-methyl-anilino)-2-(2-pyridinyl)-6-trifluoromethylpyrlmidine; 4-(2-Chloro-5-hydroxyanilino)-2-(2-pyridinyl)-6-trifluormethylpyrimidine; 4-(2-Methoxy-5-methylanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Ethanesulfonyl-5-hydroxyanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Hydroxy-5-isopropylanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine; 4-(5-Hydroxy-2-methyl-anilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(2-Chloro-5-hydroxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(3,5-Dimethoxyanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2,5-Dimethylanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Chloro-2-methoxy-anilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Chloro-2-hydroxy-anilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine; 4-(5-Hydroxy-2-isopropyl-anilino)-2-(2-pyrazinyl)-6-trifluoromethypyrimidine; 4-(2,5-Dimethoxyphenylethylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2,5-Dimethyl-4-hydroxyanilino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(3,4,5-Trichloroanilino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Cyano-4,5-dimethoxyanilino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(3-Methoxy-dibenzofuran-4-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(1,5,6-Trimethyl-benzimidazol-4-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2,6-Dimethoxypyridin-3-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Methoxy-pyridin-5-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(4,6-Dimethoxy-pyrimidin-2-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(5-Chloro-2-methyl-pyrimidin-4-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Hydroxy-5-methyl-pyrimidin-4-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(1,3,4-Triazol-1-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(Indol-4-ylamino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Methyl-indol-5-ylamino)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine; 4-(2-Chloro-5-methoxy-anilino)-2-(2-pyrimidinyl)-6-trifluoromethylpyrimidine hydrochloride; 4-(2-Chloro-5-methoxyanilino)-2-(3-pyridinyl)-6-(t-butyl)pyrimidine; 4-(3-Methoxyanilino)-2-(2-piperidinyl)-6-(trifluoromethyl)pyrimidine; 4-(2-Chloro-5-methoxyanilino)-2-(4-pyridinyl-N-oxide)-6-(trifluoromethyl)pyrimidine; 4-(4-Chloro-2-methoxy-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; 4-(2,4,5-Trimethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine; and 4-(2,4-Dichloro-5-hydroxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine.