Patent ID: 9035021
Filing Date: 2015-05-19
Classification: A61K,A61P,C07K,Y02P

Abstract:
1. A process for the production of a compound of formula or a salt thereof, comprising cyclising a linear peptide selected from the group consisting of DTrp-Lys-Xa1-Phe-Xa2-Xa3, Xa3-DTrp-Lys-Xa1-Phe-Xa2, Xa2-Xa3-DTrp-Lys-Xa1-Phe, Phe-Xa2-Xa3-DTrp-Lys-Xa1, Xa1-Phe-Xa2-Xa3-DTrp-Lys, and Lys-Xa1-Phe-Xa2-Xa3-Trp, wherein Xa1 represents O-benzyl-tyrosine, Xa2 represents 2-carboxy-4-(2-aminoethyl-carbonyloxyamino)pyrrolidine, and Xa3 represents phenylglycine, respectively, in protected form or in protected and polymer bound form and removing the protecting group(s) or cleaving from the polymer and removing the protecting group(s), in such a way to obtain said compound, and recovering said compound in free or salt form.