Patent ID: 6617456
Filing Date: 2003-09-09
Classification: A61K,A61P,C08B

Abstract:
A compound comprising a camptothecin compound represented by the formula (I): whereinany two substituent variables R1, R2, R3, R4 and R5 that are adjacent to one another combine to form an alkylene group, two of the remaining three substituent variables among R1, R2, R3, R4 and R5 are hydrogen, and the remaining substituent variable among R1, R2, R3, R4 and R5 is a group of the formula: â€”Xn-Alkm-R6, wherein one or two methylene groups of the alkylene group is optionally replaced with â€”Oâ€”, â€”Sâ€” or â€”NHâ€”, X is â€”Oâ€” or â€”NHâ€”, Alk is an alkylene group, R6 is â€”NHâ€”R7, a group of the formula: m and n are both 0 or 1, or m is 1 and n is 0, and R7 is an amino acid or peptide, provided that R3 and R4 do not combine to form a methylenedioxy group; or a salt thereof.