Patent ID: 6306897
Filing Date: 2001-10-23
Classification: A61K,A61P,C07D

Abstract:
A method for inhibiting the activity of Tec family tyrosine kinase, comprising contacting the kinase with a compound of formula (I): ##STR12##where:R.sup.7 is --C(.dbd.O)R.sup.8, --CH(--OH)--R.sup.8, or --CH.sub.2 --R.sup.8 wherein R.sup.8 is (C.sub.1 -C.sub.4) alkyl, or R.sup.7 and X.sup.1 together form a fused pyran ring;R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.14, R.sup.15 and R.sup.16 are the same or different, and are each independently H, OH, SH, CN, halogen, (C.sub.1 -C.sub.4) alkoxy, (C.sub.1 -C.sub.4) alkylthio, (C.sub.1 -C.sub.4) alkyl, (C.sub.3 -C.sub.7) cycloalkyl, aryl, heteroaryl, or NR.sub.a R.sup.b ; wherein R.sup.a and R.sup.b are each independently hydrogen, (C.sub.1 -C.sub.4) alkyl, (C.sub.3 -C.sub.7) cycloalkyl, aryl, or heteroaryl; or R.sup.a and R.sup.b together with the nitrogen to which they are attached form a ring selected from pyrrolidino, morpholino, and thiomorpholino;-- -- -- is an optional bond;X.sup.1 is a hydrogen bonding group; andX.sup.2 is a hydrogen bonding group, with the proviso that when R.sup.16 is absent, X.sup.2 is a hydrogen bonding group that is doubly bonded to a ring carbon;or a pharmaceutically acceptable salt thereof.