Patent ID: 8283446
Filing Date: 2012-10-09
Classification: A61K,A61P,C07K

Abstract:
1. A T cell receptor (TCR) having the property of binding to SEQ ID NO: 1-Human Leukocyte Antigen (HLA)-A1 complex and comprising a TCR α variable domain and a TCR β variable domain, wherein: the TCR α variable domain has the amino acid sequence from K1 to P114 of SEQ ID NO: 2 and the TCR β variable domain has the amino acid sequence from K1 to T112 of SEQ ID NO: 3 except that, in the TCR a variable domain, at least one of the following mutations is present: 50I is mutated to 50V; 51Q is mutated to 51R; 52S is mutated to 52P; 53S is mutated to 53Y; and/or in the TCR beta variable domain, at least one of the following mutations is present: 50F is mutated to 50T; 51S is mutated to 51D; 52E is mutated to 52M; 53T is mutated to 53L; 54Q is mutated to 54L.