Patent ID: 6197980
Filing Date: 2001-03-06
Classification: A61P,C07D

Abstract:
4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1.beta.,7.beta.,10.beta.-tr ihydroxy-9-oxo-11-taxen-13.alpha.-yl (2R,3S)-3-t-butoxycarbonylamino-3-phenyl-2-hydroxypropionate trihydrate, obtained by a process of centrifugal partition chromatography, said process comprisingcentrifuging impure 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1.beta.,7.beta.,10.beta.-tr ihydroxy-9-oxo-11-taxen-13.alpha.-yl (2R,3S)-3-t-butoxycarbonylamino-3-phenyl-2-hydroxypropionate and at least four solvents, which are capable of forming two partially miscible phases in a suitable centrifugal partition chromatography apparatus, for a time sufficient to purify said 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1.beta.,7.beta.,10.beta.-tr ihydroxy-9-oxo-11-taxen-13.alpha.-yl (2R,3S)-3-tbutoxycarbonylamino-3-phenyl-2-hydroxypropionate, wherein said solvents are an aliphatic hydrocarbon, an ester, an alcohol, and water; andwherein the partition coefficient between the two partially miscible phases ranges from 0.1 to 10.