Patent ID: 8334383
Filing Date: 2012-12-18
Classification: C07D

Abstract:
1. A method for making 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert.butyl ester having the formula comprising reacting 2,4-dichloro-5-trifluoromethylpyrimidine having the formula with 4-amino-benzoic acid tert-butyl ester having the formula in the presence of a non-nucleophilic auxiliary base which is N,N-diisopropyl-ethylamine, in a solvent or mixture of solvents selected from non-nucleophilic alcohols to form 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert.butyl ester having the formula characterized in that said reaction is conducted without any Lewis acidic metal cation.