Patent ID: 6576765
Filing Date: 2003-06-10
Classification: C07C,C07D

Abstract:
A process for producing an amic acid ester represented by the following general formula (7): (wherein A is a substituted or unsubstituted lower alkylene group, a substituted or unsubstituted cycloalkylene group, a substituted or unsubstituted arylene group, a substituted or unsubstituted cycloalkylalkylene group or a substituted or unsubstituted aralkylene group; R1 is a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted cycloalkylalkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heterocyclic group or a substituted or unsubstituted heterocyclic alkyl group; and R3 is a hydrogen atom or a lower alkyl group), which process comprises reacting, in the presence of water, an amino acid represented by the following general formula (1): â€ƒ(wherein A has the same definition as given above) with a halogenated carbonic acid ester represented by the following general formula (2): â€ƒ(wherein R1 has the same definition as given above and X is a halogen atom) to form an amide compound represented by the following general formula (3): â€ƒ(wherein A and R1 have the same definitions as given above), then reacting the amide compound with a halogenated carbonic acid ester represented by the following general formula (4): â€ƒ(wherein R2 is a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted cycloalkylalkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heterocyclic group or a substituted or unsubstituted heterocyclic alkyl group; and X is a halogen atom) to form, in the system, a mixed acid anhydride represented by the following general formula (5): â€ƒ(wherein A, R1 and R2 have the same definitions as given above), and reacting the mixed acid anhydride with an amine compound represented by the following general formula (6): â€ƒ(wherein R3 has the same definition as given above and Het is a substituted or unsubstituted heterocyclic group).