Patent ID: 6013650
Filing Date: 2000-01-11
Classification: A61K

Abstract:
A method for treating a subject non-human animal or domestic pet exhibiting symptoms of anxiety comprising administering to the subject an effective anxiolytic amount of a compound of formula A or a pharmaceutically acceptable salt thereof, where formula A has the formula: ##STR30## or the pharmaceutically acceptable non-toxic salts thereof wherein: X is oxygen or sulfur;W isphenyl, thienyl, or pyridyl, orphenyl, thienyl, or pyridyl, each of which may be mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, amino, mono or dialkylamino where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms; ##STR31## wherein: A represents nitrogen or C--R.sub.1 ;B represents nitrogen or C--R.sub.2 with the proviso that not both A and B are nitrogen and not both A and B are carbon;C represents nitrogen or C--R.sub.1 ;D represents nitrogen or C--R.sub.2 with the proviso that not both C and D are nitrogen;E represents oxygen, sulfur or N--R.sub.5 ;R.sub.1 and R.sub.4 are the same or different and representhydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;R.sub.2 ishydrogen, halogen, amino, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridyalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms, 1-indanyl, 1-(1,2,3,4-tetrahydronaphthyl);1-indanyl or 1-(1,2,3,4-tetrahydronaphthyl), each of which is monosubstituted with halogen, straight or branched chain lower alkyl having 1-6, carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;OR.sub.5, COR.sub.5, CO.sub.2 R.sub.5, or OCOR.sub.5, where R.sub.5 is hydrogen, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms;--CONR.sub.6 R.sub.7 or --(CH.sub.2).sub.n NR.sub.6 R.sub.7 wheren is 0, 1, or 2;R.sub.6 is hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms; andR.sub.7 is hydrogen, phenyl, pyridyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenylalkyl or pyridylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; orNR.sub.6 R.sub.7 forms a heterocyclic group which is morpholyl, piperidyl, pyrrolidyl, or N-alkyl piperazyl; orC(OH)R.sub.10 R.sub.11 where R.sub.10 and R.sub.11 are the same or different and represent straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl, or phenylalkyl where each alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms; andR.sub.3 and R.sub.5 are the same or different and represent hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms.