Patent ID: 9109051
Filing Date: 2015-08-18
Classification: A61K,A61P,A61Q,C08B,C08J,C08L,Y10T

Abstract:
1. A method of producing crosslinked hyaluronic acid microbeads, said method comprising: (a) providing an aqueous alkaline solution comprising an alkali metal hydroxide and hyaluronic acid, or a salt thereof; (b) adding the aqueous solution from part (a) to an organic or oil phase to form a water in organic or water in oil (W/O) emulsion, wherein the amount of organic or oil phase used is from 20% to less than 50% by weight based on the sum of organic or oil phase and water; and (c) adding a solution comprising a crosslinking agent to the emulsion from part (b), wherein reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads.