Patent ID: 8338110
Filing Date: 2012-12-25
Classification: A61P,C07K,G01N

Abstract:
1. A method for characterizing a subject's risk of having cardiovascular disease, comprising: determining levels of one or more oxidized apolipoprotein A-I (apoA-I)-related biomolecules in a biological sample of blood, serum, or plasma from the subject, wherein the one or more oxidized apoA-I-related biomolecules are oxidized HDL, oxidized apoA-I, oxidized apoA-I peptide fragments derived from an oxidized apoA-I, or a combination thereof; wherein said oxidized apoA-I fragments are at least three amino acids in length and comprise an oxidized amino acid; wherein the oxidized apoA-I and the oxidized apoA-I peptide fragments are lipid-free or bound to a lipid; wherein the oxidized apoA-I and the oxidized apoA-I from which the oxidized apoA-I peptide fragments are derived have reduced cholesterol efflux stimulating activity as compared to un-oxidized apoA-I; and wherein elevated levels of the one or more apoA-I-related oxidized biomolecules in the biological sample as compared to a control value or an internal standard indicates that the subject is at risk of having cardiovascular disease.