Patent ID: 7785591
Filing Date: 2010-08-31
Classification: A61K,C07K

Abstract:
1. An antibody or an antigen-binding fragment thereof which comprises (a) a VH region which is encoded by the nucleic acid sequence SEQ ID NO: 63, SEQ ID NO: 67, SEQ ID NO: 75, SEQ ID NO: 79, SEQ ID NO: 81, SEQ ID NO: 83, SEQ ID NO: 85, SEQ ID NO: 87 or the H-CDR1-, H-CDR2- and H-CDR3 regions of one of these VH regions, and (b) a VL region which is encoded by the nucleic acid sequence SEQ ID NO: 65, SEQ ID NO: 69, SEQ ID NO: 77, SEQ ID NO: 59 or the L-CDR1-, L-CDR2- and L-CDR3-regions of one of these VL regions, wherein said antibody or antibody fragment specifically binds to the ED-B domain of fibronectin.