Patent ID: 7064132
Filing Date: 2006-06-20
Classification: A61K

Abstract:
1. A method of increasing mammalian external auditory canal patency while simultaneously providing protection against the occurrence of otitis externa therewithin comprising administering a dose of a mixture of lipid crystals, as an aerosol, through an external auditory meatus of a mammal, said mixture being comprised of at least one lipid surfactant in an amount effective in lowering surface tension of an air/liquid interface resident upon epithelial tissue lining said external auditory canal, at least one spreading agent in an amount effective in distributing said surfactant upon said interface and at least one propellant in which said surfactants and spreading agents are not soluble, said lipid surfactants and said spreading agents being selected from the group consisting of lipids, sterols, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, all in powder form; whereupon when said mixture is so administered, the propellants are evaporated from said mixture as said lipid crystals come into contact with, and deposit upon the epithelial lining of the external auditory canal and form an amorphous spread film thereupon so as to reduce the surface tension thereof while also forming a barrier thereupon to exogenous fluids.