Patent ID: 8772462
Filing Date: 2014-07-08
Classification: A61K,A61P,B01D,C07K

Abstract:
1. A method for reducing the amount of a serine protease or a serine protease zymogen in a plasma-derived target protein composition, the method comprising the steps of: (a) enriching a plasma-derived target protein, in a first target protein enrichment step comprising alcohol fractionation of a Cohn pool, thereby forming a first enriched plasma-derived target protein composition (b) contacting the first enriched plasma-derived target protein composition, or a further enriched composition thereof, with finely divided silicon dioxide (SiO (c) separating the SiO wherein the at least one serine protease or serine protease zymogen is Factor XIa (FXIa), Factor XIIa (FXIIa), Factor XI (FXI), or Factor XII (FXII) and further wherein the plasma-derived target protein is selected from albumin, alpha-1-antitrypsin (A1PI), a protein of the complement system, and an inter-alpha-trypsin inhibitor (IαI).