Patent ID: 6110951
Filing Date: 2000-08-29
Classification: A61K

Abstract:
A method for controlling essential hypertension and its related cardiovascular syndrome in a mammalian host in need thereof by administration of an effective amount of a 5-aryl substituted thiazolidine derivative of formula I ##STR47## where: R.sub.1 is an aromatic carbocyclic or an aromatic heterocyclic;X is a lower alkylene or a bond, or --HC.dbd.CH--,Y is oxo or imino;Z is oxo or imino; orpharmaceutically acceptable salts thereof with the proviso that R.sub.1 is not of the formula. ##STR48## where n is 1-4, and where R.sub.31 is a hydrogen or a lower alkyl of 1-4 carbons and the cyclohexane ring may be optionally substituted at any available methylene with a single oxo or hydroxy;and, when Z and Y are both oxo, R.sub.1 cannot be an oxyalkylamine substituted phenyl wherein the amine is a secondary or tertiary amine.