Patent ID: 8412460
Filing Date: 2013-04-02
Classification: C12Q,C40B,G01N,G16B

Abstract:
1. A method for characterizing a cellular constituent as being associated or not being associated with a biological function, said method comprises on a suitably programmed computer identifying one or more response profiles associated with a known biological function as either correlating or not correlating with a response profile for the cellular constituent being characterized, wherein: (a) each of said one or more response profiles associated with said known biological function comprises changes of a plurality of cellular constituents in a biological sample in which a particular cellular constituent, other than the cellular constituent being characterized, that is associated with said known biological function is perturbed, (b) said response profile for the cellular constituent being characterized comprises changes of measured amounts of a plurality of cellular constituents in a biological sample in which the cellular constituent being characterized is perturbed, and (c) either the cellular constituent being characterized is characterized as being associated with said known biological function if said response profile for said cellular constituent being characterized correlates with said response profile associated with said known biological function, or the cellular constituent being characterized is characterized as not being associated with said known biological function if said response profile for said cellular constituent being characterized does not correlate with said response profile associated with said known biological function, and wherein the one or more response profiles associated with a known biological function that correlate with the response profile for the cellular constituent being characterized are identified by a method which comprises: clustering a plurality of response profiles so that response profiles that are correlated are located within a particular cluster; and identifying response profiles that cluster with the response profile for the cellular constituent being characterized.