Patent ID: 6271263
Filing Date: 2001-08-07
Classification: A61K,C07C

Abstract:
A compound of the formula: ##STR12##wherein n is 0 or 1;each of R.sub.1 and R2 are independently hydrogen, substituted or unsubstituted C.sub.1 -C.sub.4 alkyl, or halogen;R.sub.3 is hydrogen, substituted or unsubstituted C.sub.1 -C.sub.4 alkyl, hydroxy, or substituted or unsubstituted C.sub.1 -C.sub.4 alkoxy;R.sub.4 is hydrogen, or substituted or unsubstituted C.sub.1 -C.sub.12 alkyl; andR.sub.5 is --C(O)--R.sub.6, --Y--(O)--NR.sub.9 R.sub.10 or Y--(SO.sub.2)NR.sub.9 R.sub.10,wherein R.sub.6 is substituted C.sub.1 -C.sub.12 alkyl, substituted C.sub.6 -C.sub.14 aryl, substituted or unsubstituted C.sub.7 -C.sub.12 aralkyl, or A--N--R.sub.11 R.sub.l2,wherein A is substituted or unsubstituted C.sub.1 -C.sub.12 alkylene, andeach of R.sub.11 and R.sub.12 are independently substituted or unsubstituted C.sub.1 -C.sub.12 alkyl, substituted orunsubstituted C.sub.6 -C.sub.12 aryl, or substituted or unsubstituted C.sub.7 -C.sub.12 aralkyl, or indanyl,Y is substituted or unsubstituted C.sub.1 -C.sub.12 alkylene, and each of R.sub.9 and R.sub.10, are independently hydrogen, substituted or unsubstituted C.sub.1 -C.sub.12 alkyl, substituted or unsubstituted C.sub.1 -C.sub.12 aryl, substituted or unsubstituted C.sub.7 -C.sub.12 aralkyl or indanyl, provided that when R.sub.9 is hydrogenand R.sub.10 is phenyl, R.sub.3 is not dimethyl; and racemic mixtures, enantiomers, and salts thereof.