Patent ID: 9029508
Filing Date: 2015-05-12
Classification: A61K,A61P,C07K,G01N,Y02A,Y10S

Abstract:
1. A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker; X2 is an Fc region; n is 0 or 1; wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding VEGF and DLL4, wherein the first and second polypeptide chains of the binding protein comprise: SEQ ID NOs: 239 and 240, SEQ ID NOs: 411 and 412, SEQ ID NOs: 413 and 414, SEQ ID NOs: 419 and 420, SEQ ID NOs: 435 and 436, SEQ ID NOs: 445 and 446, SEQ ID NOs: 449 and 450, SEQ ID NOs: 453 and 454, SEQ ID NOs: 461 and 462, SEQ ID NOs: 465 and 466, SEQ ID NOs: 469 and 470, SEQ ID NOs: 473 and 474, SEQ ID NOs: 475 and 476, SEQ ID NOs: 477 and 478, SEQ ID NOs: 479 and 480, SEQ ID NOs: 481 and 482, SEQ ID NOs: 483 and 484, SEQ ID NOs: 485 and 486, SEQ ID NOs: 489 and 490, SEQ ID NOs: 493 and 494, SEQ ID NOs: 497 and 498, SEQ ID NOs: 501 and 502, SEQ ID NOs: 503 and 504, SEQ ID NOs: 507 and 508, SEQ ID NOs: 509 and 510, SEQ ID NOs: 511 and 512, SEQ ID NOs: 513 and 514, SEQ ID NOs: 517 and 518, SEQ ID NOs: 525 and 526, SEQ ID NOs: 529 and 530, SEQ ID NOs: 533 and 534, SEQ ID NOs: 537 and 538, SEQ ID NOs: 541 and 542, SEQ ID NOs: 543 and 544, SEQ ID NOs: 545 and 546, SEQ ID NOs: 557 and 558, SEQ ID NOs: 559 and 560, SEQ ID NOs: 561 and 562, SEQ ID NOs: 585 and 586, SEQ ID NOs: 589 and 590, or SEQ ID NOs: 593 and 594.