Patent ID: 6384014
Filing Date: 2002-05-07
Classification: A61K,A61P,C07K

Abstract:
A cocrystallizate comprising at least one component from the streptogramin B group defined by the formula (I): in which:R1 represents a methyl or ethyl radical, R2 represents a hydrogen atom or a hydroxyl radical, and R3 represents a substituted benzyl radical of formula (III): â€ƒin which: (1) R2 in formula (1) is hydrogen, and R represents: NR4R5 wherein one of R4 and R5 is a hydrogen atom or a methyl radical and the other is a methyl radical, and Râ€² is a chlorine or bromine atom; or an alkenyl radical containing 3 to 5 carbon atoms when R4 and R5 are both methyl radicals; or, alternatively, (2) R represents a hydrogen atom and Râ€² represents a halogen atom, an alkylamino or dialkylamino radical an ether oxide residue OR0 where R0 is a methyl group, an ethyl group which is optionally substituted with a chlorine atom, an allyl group, or a trifluoromethyl group, an alkylthio radical, an alkyl radical containing 1 to 3 carbon atoms in a straight or branched chain or a trihalomethyl radical; or, alternatively, (3) R represents a halogen atom, an alkylamino radical containing 2 to 4 carbon atoms in a straight or branched chain, a dialkylamino radical in which the alkyl parts are identical or different and contain 2 to 4 carbon atoms in a straight or branched chain or a methylethylamino radical, a pyrrolidino radical, an alkenylalkylamino radical in which the alkenyl part contains 3 or 4 carbon atoms and the alkyl part is defined as above, a dialkenylamino radical in which the alkenyl parts are defined as above, an alkylcycloalkylmethylamino radical in which the alkyl part is defined as above and the cycloalkyl part contains 3 or 4 carbon atoms, an ether oxide residue OR0 where R0 is a methyl group, an ethyl group which is optionally substituted with a chlorine atom, an allyl group, or a trifluoromethyl group, an alkylthio radical, an alkylthiomethyl radical, an alkyl radical containing 1 to 6 carbon atoms in a straight or branched chain, an aryl radical or a trihalomethyl radical, and Râ€² is a hydrogen atom; or, alternatively, (4) R represents a halogen atom, an amino, alkylamino or dialkylamino radical, an ether oxide residue OR0 where R0 is a methyl group, an ethyl group which is optionally substituted with a chlorine atom, an allyl group, or a trifluoromethyl group, an alkylthio radical, an alkyl radical containing 1 to 6 carbon atoms in a straight or branched chain or a trihalomethyl radical and Râ€² represents a halogen atom, an alkylamino or dialkylamino radical, an ether oxide residue OR0 where R0 is a methyl group, an ethyl group which is optionally substituted with a chlorine atom, an allyl group, or a trifluoromethyl group, or an alkylthio or alkyl radical containing 1 to 3 carbon atoms in a straight or branched chain; and at least one component of the streptogramin A group, of formula (II): in which Râ€³ is a hydrogen atom or a methyl or ethyl radical;with the proviso that, except where specifically mentioned, the alkyl radicals are straight or branched and contain 1 to 4 carbon atoms.