Patent ID: 8748564
Filing Date: 2014-06-10
Classification: A61K,A61P,C07K

Abstract:
1. A compound represented by structural Formula I: wherein W and X are independently selected from CH A is an amino acid selected from: alanine substituted on the side chain with a 5- or 6-membered heteroaromatic ring; and phenylalanine substituted on the phenyl ring with halogen, C B is an amino acid selected from: isoleucine; and glycine substituted on the α-carbon with C C is an amino acid selected from: proline, optionally substituted on the side chain with hydroxyl, C D is an amino acid selected from: leucine; homoleucine; isoleucine; and glycine substituted on the α-carbon with C E is an amino acid selected from: glycine and azaglycine, with the proviso that if C is 4-hydroxyproline, then A must be either phenylalanine substituted on the phenyl ring with halogen, or C with the further proviso that if A is phenylalanine substituted on the phenyl ring with C with the further proviso that if A is phenylalanine substituted on the phenyl ring with halogen, then either B or D must be glycine substituted on the α-carbon with C