Patent ID: 7687631
Filing Date: 2010-03-30
Classification: A61P,C07D,C07F

Abstract:
1. A process for making a compound having the structure of compound 11: wherein R1 is an alkyl group of from 1 to about 4 carbon atoms, the process comprising: (a) reacting (5-halo-pyridin-2-yl)-methanol of the Formula 137A where X with an X where X (b) reacting compound 137 with a phosphite compound of the structure of Formula A: wherein R 9 is selected from alkyl, aryl, heteroaryl, and arylalkyl groups having 1 to 10 carbon atoms, to produce compound 138: wherein R (c) treating compound 138 with HX (d) reacting the hydrohalide salt from step “c” with a 3-flurophenylboronate compound of the structure of Formula B wherein R 11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, optionally in the presence of a palladium catalyst to produce compound 116.