Patent ID: 6262094
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
Compound having the general formula I ##STR40##where:P--Q is a C, C double bond or an epoxide;G is ##STR41##R is selected from the group of H, alkyl, and substituted alkyl;R.sup.1 is selected from the group consisting of ##STR42##G.sup.1 is selected from the group of H, halogen, CN, alkyl and substituted alkyl;G.sup.2 is selected from the group of H, alkyl, and substituted alkyl;G.sup.3 is selected from the group of O, S, and NZ.sup.1 ;G.sup.4 is selected from the group of H, alkyl, substituted alkyl, OZ.sup.2, NZ.sup.2 Z.sup.3, Z.sup.2 C.dbd.O, Z.sup.4 SO.sub.2, and optionally substituted glycosyl;G.sup.5 is selected from the group of halogen, N.sub.3, NCS, SH, CN, NC, N(Z.sup.1).sub.3.sup.+ and heteroaryl;G.sup.6 is selected from the group of H, alkyl, substituted alkyl, CF.sub.3, OZ.sup.5, SZ.sup.5, and NZ.sup.5 Z.sup.6 ;G.sup.7 is CZ.sup.7 or N;G.sup.8 is selected from the group of H, halogen, alkyl, substituted alkyl, OZ.sup.10, SZ.sup.10, NZ.sup.10 Z.sup.11 ;G.sup.9 is selected from the group of O, S, --NH--NH-- and --N.dbd.N--;G.sup.10 is N or CZ.sup.12 ;G.sup.11 is selected from the group of H.sub.2 N, substituted H.sub.2 N, alkyl, substituted alkyl, aryl, and substituted aryl;Z.sup.1, Z.sup.6, Z.sup.9, and Z.sup.11 are independently selected from the group H, alkyl, substituted alkyl, acyl, and substituted acyl;Z.sup.2 is selected from the group of H, alkyl, substituted alkyl, aryl, substituted aryl, and heterocycle;Z.sup.3, Z.sup.5, Z.sup.8, and Z.sup.10 are independently selected from the group H, alkyl, substituted alkyl, acyl, substituted acyl, aryl, and substituted aryl;Z.sup.4 is selected from the group of alkyl, substituted alkyl, aryl, substituted aryl, and heterocycle;Z.sup.7 is selected from the group of H, halogen, alkyl, substituted alkyl, aryl, substituted aryl, OZ.sup.8, SZ.sup.8, and NZ.sup.8 Z.sup.9 ; andZ.sup.12 is selected from the group of H, halogen, alkyl, substituted alkyl, aryl, and substituted aryl;with the proviso that when R.sup.1 is ##STR43##G.sup.1, G.sup.2, G.sup.3 and G.sup.4 cannot simultaneously have the following meanings:G.sup.1 and G.sup.2 =H, G.sup.3 =O and G.sup.4 =H or Z.sup.2 C.dbd.O where Z.sup.2 =alkyl groupand with the proviso that when R.sup.1 is ##STR44##G.sup.1, G.sup.2, and G.sup.5 cannot simultaneously have the following meanings: G.sup.1 and G.sup.2 =H, and G.sup.5 =F.