Patent ID: 8834920
Filing Date: 2014-09-16
Classification: A61K,A61P,C07K

Abstract:
1. A composition, comprising liposomes comprised of (i) vesicle-forming lipids; (ii) a lipopolymer; (iii) a conjugate comprised of a hydrophobic moiety, a hydrophilic polymer, and a peptide which exhibits one or more properties selected from a) competitive binding with known EGFR ligands, EGF and TGF-α; b) ability to compete with the neutralizing monoclonal antibody cetuximab for binding to EGFR; c) binding to a non-ligand binding domain on EGFR; and d) ability to bind to extracellular domain of EGFR in the presence of EGF; and (iv) an entrapped drug, wherein the peptide has the amino acid sequence selected from SEQ ID NOs 6, 7, 8, 9 or 55.