Patent ID: 6380193
Filing Date: 2002-04-30
Classification: A61K,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein:Y represents the atoms necessary to form a fused 5- to 6-membered, aromatic or non-aromatic-N-heterocyclic ring, containing 1-3 nitrogen atoms (or 1-2 carbocyclic fused rings) wherein Y and any heteroatom(s) therein is unsubstituted or independently substituted with non-interfering hydroxy, amino, nitro, dimethylamino, alkylamino, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl substituents; R3 is double bonded oxygen; R2, when present, is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl; R1, R4, R5 and R6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or aryl; whereinR2, R4, R5 and R6 are unsubstituted or independently substituted with a moiety selected from the group consisting of alkyl, alkenyl, alkoxy, phenoxy, benzyloxy, cycloalkyl, cycloalkenyl, hydroxy, carboxy, carbonyl, amino, dimethylamino, alkylamino, amido, cyano, isocyano, nitro, nitroso, nitrilo, isonitrilo, imino, azo, diazo, sulfonyl, sulfoxy, thio, thiocarbonyl, sulfhydryl, halo, haloalkyl, trifluoromethyl and aryl; provided that (i) where R1, R2, R4, R5 and R6 are not each hydrogen when Y is a 5-membered, unsaturated-N-heterocyclic ring; and (ii) when R2 is methyl and R4, R5 and R6 are hydrogen, Y is not methyl or phenyl 2-substituted pyrrolyl.