Patent ID: 7932225
Filing Date: 2011-04-26
Classification: A61K,A61P,B82Y

Abstract:
1. A method of reducing lung volume in a lung of a subject in need thereof comprising: providing a glue composition comprising a first adhering moiety connected with a second adhering moiety, wherein the first and second adhering moieties are independently selected from the group consisting of a) alpha-1 antitrypsin, b) elafin, and c) serpin, and wherein the first and second adhering moieties adhere to different sites bearing elastase in a lung; administering an effective amount of the glue composition to a localized region of damaged lung tissue of the subject; adhering the first adhering moiety to a first site bearing elastase in the localized region of damaged lung tissue of the subject; collapsing a first portion or all of the lung of said subject wherein the first portion comprises the localized region of damaged lung tissue; adhering the second adhering moiety to a second site bearing elastase in the damaged lung tissue; and re-inflating a second portion of the lung of the subject wherein the second portion does not comprise the damaged lung tissue, thereby reducing the lung volume.