Patent ID: 6242199
Filing Date: 2001-06-05
Classification: C07K,C12Q,G01N

Abstract:
A method to determine the presence of a growth hormone secretagogue receptor ligand comprising:a) introducing a nucleic acid which encodes a growth hormone secretagogue receptor (GHSR) into a cell under conditions so that said growth hormone secretagogue receptor is expressed:b) introducing a detector molecule or a nucleic acid encoding a detector molecule into the cell, wherein the detector molecule is directly or indirectly responsive to a GHSR-ligand binding event;c) contacting the cell with a compound suspected of being a growth hormone secretagogue receptor ligand; andd) determining whether the compound is a growth hormone secretagogue receptor ligand by detecting a response of the detector molecule, wherein a response of the detector molecule indicates the presence of a GHSR-ligand.