Patent ID: 8008352
Filing Date: 2011-08-30
Classification: A61P,C07C,Y10S

Abstract:
1. A method for the treatment of arrhythmias, life-threatening cardiac ventricular fibrillation, myocardial infarction, angina pectoris, ischemic states of the heart, heart failure or congestive heart failure in a subject in need thereof, said method comprising the administration to said subject a therapeutically effective amount of a pentafluorosulfanylbenzoylguanidine compound of the formula I or II in which R1 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, F, Cl, Br, I, CN, NR10R11, —O R10 and R11 are, independently of one another, hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or —CH m is zero, 1 or 2 n, o, p, q, r and s are, independently of one another, zero or 1; R2 is hydrogen, F, Cl, Br, I, —CN, —SO h is zero, 1 or 2; z is zero or 1; k is zero, 1, 2, 3 or 4; 1 is zero or 1; R3 and R4 are, independently of one another, hydrogen or F; or a pharmaceutically acceptable salt thereof.