Patent ID: 7491722
Filing Date: 2009-02-17
Classification: A61P,C07D

Abstract:
1. A pyridazin-3(2H)-one derivative compound of formula (I): wherein R a hydrogen atom; a group chosen from acyl, hydroxycarbonyl, alkoxycarbonyl, carbamoyl, monoalkylcarbamoyl and dialkylcarbamoyl; an alkyl, alkenyl or alkynyl group, wherein said alkyl, alkenyl or alkynyl group is optionally substituted by one or more substituents chosen from halogen atoms, hydroxy, alkoxy, aryloxy, alkylthio, oxo, amino, mono- and di-alkylamino, acylamino, carbamoyl and mono- and di-alkylcarbamoyl groups; an aryl or heteroaryl group, wherein said aryl or heteroaryl group is optionally substituted by one or more substituents chosen from halogen atoms, hydroxy, hydroxyalkyl, hydroxycarbonyl, alkoxy, alkylenedioxy, alkoxyacyl, aryloxy, acyl, acyloxy, alkylthio, amino, nitro, cyano, mono- and di-alkylamino, acylamino, carbamoyl, mono- and di-alkylcarbamoyl, difluoromethyl, trifluoromethyl, difluoromethoxy and trifluoromethoxy groups; a saturated or unsaturated heterocyclic group, which is optionally substituted by one or more substituents chosen from halogen atoms, hydroxy, hydroxyalkyl, hydroxycarbonyl, alkoxy, alkylenedioxy, alkoxyacyl, aryloxy, acyl, acyloxy, alkylthio, oxo, amino, nitro, cyano, mono- and di-alkylamino, acylamino, carbamoyl, mono- and di-alkylcarbamoyl, difluoromethyl, trifluoromethyl, difluoromethoxy and trifluoromethoxy groups; a group of formula wherein n is an integer from 0 to 4 and R R R wherein R wherein n and R R wherein n and R or a N-oxide obtainable from heteroaryl radicals present in the structure when said heteroradical comprise at least one N atom or a pharmaceutically acceptable salt thereof; with the proviso that when R