Patent ID: 6310059
Filing Date: 2001-10-30
Classification: A61K,A61P,C07D,C40B

Abstract:
A method to treat conditions associated with undesired calcium channel activity in a subject which method comprises administering to a subject in need of such treatment a compound of the formula ##STR8##or the salts thereof,wherein Z is N or CH;wherein n is 0 or 1;X.sup.1 and X.sup.2 are linkers;Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic rings, andCy represents one or two substituted or unsubstituted aliphatic cyclic or heterocyclic moietics, or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic moiety and one substituted or unsubstituted aromatic or heteroaromatic moiety,Y is O, S, NR or CR.sub.2 where R is H or alkyl (1-6C);each l.sup.1 and l.sup.2 is independently 0-4;l.sup.3 is 0 or 1;each of R.sup.1, R.sup.2 and R.sup.3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or may independently be halo, OR, SR, NR.sub.2, OOCR, NROCR, COR, COOR, CONR.sub.2, CF.sub.3, CN or NO.sub.2, wherein R is H or alkyl (1-6C), andwherein the dotted lines represent optional .pi.-bonds, orcompounds of formulas (1a) or (1b) where (X.sup.2).sub.n Ar or (X.sup.2).sub.n Cy is replaced by alkyl (1-6C).