Patent ID: 9107950
Filing Date: 2015-08-18
Classification: A61K,B01J

Abstract:
1. A microbubble method comprising: generating a plurality of microbubbles by ultrasonically agitating an interface between a lipid solution and a first gas in a reaction volume, each generated microbubble having a lipid monolayer shell surrounding a core of the first gas; freezing the generated plurality of microbubbles so as to remove water and the first gas therefrom, leaving behind freeze-dried lipid monolayer shells; sealing the freeze-dried lipid monolayer shells in a storage container under vacuum; storing the freeze-dried lipid monolayer shells under vacuum in the sealed storage container for at least a first time period; and after the first time period, exposing the freeze-dried lipid monolayer shells to an atmosphere of a second gas such that the core of each lipid monolayer shell is filled with the second gas, wherein the second gas is different from the first gas.