Patent ID: 6310095
Filing Date: 2001-10-30
Classification: C07B,C07C,C07D,C07F

Abstract:
A compound having Formula I ##STR4238##or a pharmaceutically acceptable salt thereof, whereinR.sub.1 is aryl-L.sub.2 --wherein aryl is phenyl, unsubstituted or substituted with at least one of X, Y, or Z wherein X, Y, and Z are independently selected from the group consisting ofalkenyl,alkynyl,alkoxy,cyano,halogen,haloalkyl,hydroxy,hydroxyalkyl,loweralkyl,thioalkoxy andL.sub.2 is absent;R.sub.2 is --L.sub.11 --C(R.sub.14)(R.sub.v)13 C(O)OR.sub.15 wherein L.sub.11 is --C(W)N(R)--whereinR is hydrogen and W i s O,R.sub.v is selected from the group consisting of hydrogen and loweralkyl,R.sub.15 is selected from the group consisting of(a) hydrogen,(b) alkanoyloxyalkyl,(c) loweralkyl, and(b) a carboxy-protecting group, andR.sub.14 is thioalkoxyalky;L.sub.1 is --L.sub.4 --N(R.sub.5)--L.sub.5 -- wherein L.sub.4 is absent or C.sub.1 -to-C.sub.10 -alkylene;L.sub.5 is absent or C.sub.1 -to-C.sub.10 -alkylene andR.sub.5 is selected from the group consisting ofhydrogen,alkanoyl,alkoxy,alkoxyalkyl,alkoxycarbonyl wherein the alkoxycarbonyl is unsubstituted or substituted with 1, 2 or 3 halogen,alkylaminocarbonylalkylcycloalkoxycarbonyl,cycloalkylaminocarbonyl,cycloalkylaminothiocarbonyl,cycloalkylalkyl,(cyclolalkyl)oyl,haloalkyl,loweralkyl, wherein the loweralkyl is unsubstituted or substituted with --NRR', wherein R and R' are independently hydrogen or loweralkyl;--S02-A, wherein A is loweralkyl optionally substituted with alkoxy or 1-5 halogen(s); andthioalkoxyalkyl;Z is a covalent bond,R.sub.3 is cycloalkyl, wherein the cycloalkyl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of(a) alkoxy,(b) loweralkyl,(c) halogen,(d) NR.sup.R3 R.sup.R3, wherein R3 and R3' are hydrogen, loweralkyl or cycloalkyl, and(e) oxo; andR.sub.4 is hydrogen.