Patent ID: 7544809
Filing Date: 2009-06-09
Classification: A61P,C07D

Abstract:
1. A process for preparing a compounds of formula IV, comprising reacting an aromatic aldehyde of formula I with an α-ketoxime of formula II wherein: R R R R R R W is CH, N, if o=1; W is O, S, NR12, if o=0; o is 0 or 1; R12 is H, (C1-C6)-alkyl, (C1-C6)-alkylenephenyl, or phenyl; R R or R R to get an N-oxide of formula III wherein R n1 is 0, 1, ½ or ⅓; and reacting the N-oxide of formula III with the reagent R to yield the compound of formula IV wherein R X X3 is Cl, Br, CH n2 is 0 or 1.