Patent ID: 6063789
Filing Date: 2000-05-16
Classification: A61P,C07D,C07F

Abstract:
A compound of formula I ##STR16## wherein: R represents(i) phenyl, benzothiazolyl or a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms, which phenyl, benzo ring of the benzothiazolyl or heterocyclic aromatic ring is optionally substituted by alkyl C1 to 6, alkoxy C1 to 6, halogen, hydroxy, thioalkyl C1 to 6, benzyloxy, or a group --Q(CH.sub.2).sub.p NR.sup.4 R.sup.5 ; or(ii) alkyl C1 to 8, cycloalkyl C3 to 8, alkynyl C2 to 8, piperidyl, phenylalkyl C7 to 14, which alkyl, cycloalkyl, alkynyl, or piperidyl is optionally substituted by a group --(CH.sub.2).sub.p NR.sup.4 R.sup.5, the phenylalkyl being optionally substituted by a group --(CH.sub.2).sub.p NR.sup.5 R.sup.5, alkyl C1 to 6, alkoxy C1 to 6, halogen or nitro; or(iii) a 5 membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O, N or S, optionally substituted by alkyl C1 to 6, phenylalkyl C7 to 14 or halogen; or(iv) hydrogen or phenylalkynyl C7 to 14;Q represents O, NR.sup.6 or a bond;R.sup.1 represents hydrogen, alkyl C1 to 6, alkoxy C1 to 6, trimethylsilyl or halogen;R.sup.2 represents hydrogen, alkyl C1 to 6 or phenyl optionally substituted by alkyl C1 to 6, alkoxy C1 to 6, halogen or hydroxy;R represents hydrogen or halogen;R.sup.4, R.sup.5 and R.sup.6 independently represent hydrogen or alkyl C1 to 6,or --NR.sup.4 R.sup.5 together represents piperidyl, pyrrolidinyl or morpholinyl;p represents an integer 1 to 5; andA represents a thieno or benzo ring;provided that when A represents a benzo ring and Q represents O, p does not represent 1; or a pharmaceutically acceptable salt, enantiomer or tautomer thereof;provided that when A represents a benzo ring, compounds of formula I in which R represents hydrogen, alkyl C1 to 6 or phenyl, R.sup.1 represents hydrogen, alkyl C1 to 6, alkoxy C1 to 6 or halogen, R.sup.2 represents hydrogen, alkyl C1 to 6 or unsubstituted phenyl and R.sup.3 represents hydrogen are disclaimed.