Patent ID: 6632426
Filing Date: 2003-10-14
Classification: A61K,A61P,C07K,Y02A

Abstract:
A G-CSF molecule, optionally with an N-terminal methionyl residue, comprising:(a) a G-CSF internal core of helices A, B, C and D as set forth in FIG. 4, said internal core helices comprising corresponding amino acid residues as set forth in SEQ. ID. NO. 2, optionally with the cysteine residue at position 18 altered to serine or alanine residue; (b) an external loop between helices A and B comprising corresponding amino acid residues as set forth in SEQ. ID. NO. 2; (c) an external loop between helices B and C comprising corresponding amino acid residues as set forth in SEQ. ID. NO. 2; (d) an external loop between helices D and A; and (e) a N-terminus and a C-terminus, said N-terminus being connected to helix D and said C-terminus being connected to helix C, said N-terminus and said C-terminus each comprising a portion of amino acids 120-146 of SEQ. ID. NO. 2.