Patent ID: 8450490
Filing Date: 2013-05-28
Classification: A61P,C07D

Abstract:
1. A method for treating pulmonary inflammation or bronchoconstriction in a human in need thereof, comprising administering to said human an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: is selected from: wherein R 1 is CH 2 OH, CH 2 CH 2 OH, N(H)C(O)H, N(H)S(O 2 )CH 3 , and R 2 is H: or X is a bicyclic, fused heterocyclic ring selected from the group of: wherein said bicyclic fused heterocyclic ring is optionally substituted with one, two or three additional substituents independently selected from alkyl, oxo, and OH; R wherein said alkylene, alkenylene, alkynylene, cycloalkylene, or arylene is optionally substituted with 1, 2 or 3 substituents selected from halo, oxo, and OR 8 ; Het is 5-6 membered saturated or unsaturated heterocyclene selected from the group of: and wherein said 5-membered or 6-membered saturated or unsaturated heterocyclene is optionally substituted with 1, 2 or 3 substituents selected from halo, alkyl, alkoxy, oxo, and OH; R Y is C(O), C(O)N(R R R R wherein Z is O, S, S(O) R R