Patent ID: 6399779
Filing Date: 2002-06-04
Classification: C07C,C07D,C07F

Abstract:
A process for covalently coupling an aromatic ring compound with an organic compound which comprises the following steps:(i) reacting an aromatic ring compound having at a ring coupling position a halogen substituent or other substituent which undergoes substitution with a diboronic acid ester, with a diboronic acid ester in the presence of a Group VIII metal catalyst and a base which catalyzes, promotes or assists the reaction to form an arylboronic acid ester, said reaction proceeding by a substitution reaction between said diboronic acid ester and said halogen or other substituent of the aromatic ring compound, and (ii) reacting the arylboronic acid ester so formed with an organic compound having at a coupling position a halogen substituent or other substituent which undergoes substitution with the arylboronic acid ester, in the presence of a Group VIII metal catalyst and a base which catalyzes, promotes or assists the reaction, whereby the aromatic ring compound is coupled to the organic compound via a direct bond between respective coupling positions, wherein said aromatic ring compound has at least one further substituent selected from the group consisting of hydroxy, amino, imino, acetylene, carboxy, carboximidyl, sulfo, sulfinyl, sulfinimidyl, sulfinohydroximyl, sulfonimidyl, sulfondiimidyl, sulfonohydroximyl, sultamyl, phosphinyl, phosphinimidyl, phosphonyl, dihydroxyphosphanyl, hydroxyphosphanyl, phosphono, phosphonato, hydrohydroxyphosphoryl, allophanyl, guanidino, hydantoyl, ureido, and ureylene.