Patent ID: 8575319
Filing Date: 2013-11-05
Classification: A61K,A61P

Abstract:
1. A method of making a cancer vaccine which comprises conjugating an immunogenic carrier comprising keyhole limpet hemocyanin (KLH) with a partially-reduced tumor-specific idiotypic immunoglobulin using a linker comprising a first reactive moiety which is maleimide and a second reactive moiety under conditions which permit the formation of a thio-ether bond between the partially-reduced tumor-specific idiotypic immunoglobulin and the first reactive moiety and a covalent bond between the immunogenic carrier and the second reactive moiety to give the cancer vaccine, wherein the thio-ether bond between the linker and the partially-reduced tumor-specific idiotypic immunoglobulin is cleavable under lysosomal processing conditions, and wherein the tumor-specific idiotypic immunoglobulin is associated with a B-cell proliferative disease selected from the group consisting of B-cell lymphoma, leukemia, multiple myeloma and light chain amyloidosis.