Patent ID: 6359145
Filing Date: 2002-03-19
Classification: A61P,C07D,C07F

Abstract:
A compound of the formula whereinR1 is hydrogen, hydroxy, protected hydroxy, unsubstituted aryl or aryl substituted with at least one substituent selected from the group consisting of halo(lower)alkyl, halogen, hydroxy, protected carboxy, carbamoyl, lower alkylenedioxy, lower alkoxy optionally substituted with aryl, and lower alkyl optionally substituted with hydroxy or protected carboxy; R2 is hydrogen or lower alkyl; R3 is hydroxy or protected hydroxy; R4 is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, unsubstituted carbamoyl or carbamoyl substituted with at least one substituent selected from the group consisting of amino, hydroxy, lower alkyl, lower alkylsulfonyl and aminoimino(lower)alkyl optionally substituted with hydroxy; and â€”Aâ€” is â€”Qâ€” or â€”Oâ€”Qâ€”, wherein Q is single bond or lower alkylene, provided that when R2 is lower alkyl, then R1 is hydroxy, protected hydroxy, or aryl optionally substituted with at least one substituent selected from the group consisting of halo(lower)alkyl, halogen, hydroxy, protected carboxy, carbamoyl, lower alkylenedioxy, lower alkoxy optionally substituted with aryl, and lower alkyl optionally substituted with hydroxy or protected carboxy; its prodrug, or its salt.