Patent ID: 6395762
Filing Date: 2002-05-28
Classification: A61P,C07C,C07D

Abstract:
A compound of formula I having the structure (a) phenyl optionally substituted with 1-3 Y groups; (b) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; (c) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; or (d) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, having a second phenyl ring fused to the heterocyclic ring, optionally substituted with 1-2 Y groups; X is â€”OCH2â€” or a bond; Y is hydroxy, halogen, cyano, â€”SOmR4, â€”SOnNR4R5, â€”NHSO2R4, â€”NR4R5, alkyl of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkoxy of 1-10 carbon atoms, arylalkoxy, â€”COR4, or â€”CO2R4; R1 and R2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-8 carbon atoms; R3 is (a) alkyl of 1-10 carbon atoms, optionally substituted with 1-5 groups selected from the goup consisting of halogen; hydroxy; spirocycloalkyl of 5-7 carbon atoms, phenyl optionally mono- or di-substituted with Z; oxo; â€”CO2H; â€”CO2R4; amino; â€”NR4R5; and â€”NHCOR4; (b) cycloalkyl of 3-8 carbon atoms; (c) arylalkyl wherein the alkyl moiety contains 1-10 carbon atoms; (d) heterocycle or heterocyclealkyl, wherein the alkyl moiety contains 1-6 carbon atoms, and the heterocycle is i) a 5-6 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; ii) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, optionally substituted with 1-2 Y groups; or iii) a phenyl fused heterocycle having 1-4 heteroatoms selected from O, N, and S, having a second phenyl ring fused to the heterocyclic ring, optionally substituted with 1-2 Y groups; R4 and R5 are each, independently, hydrogen, alkyl of 1-10 carbon atoms, or cycloalkyl of 3-8 carbon atoms; Z is halogen, alkyl of 1-10 carbon atoms, â€”CO2R4, benzyloxy, â€”NHC(O)NHR4, â€”NR4R5, â€”OR4, â€”COR4, â€”S(O)mR4; or â€”S(O)nNR4R5; m=0-2; n=1-2; or a pharmaceutically acceptable salt thereof.