Patent ID: 8110703
Filing Date: 2012-02-07
Classification: A61P,C07C

Abstract:
1. A retinoid derivative of the formula (I), or an isomer, enantiomer, racemate, diastereomer mixture, racemic mixture, or pharmaceutically acceptable salt thereof, wherein: R1 represents a structure of formula (II) or formula (III), and R2 represents a structure of formula (IV), R3-R7 are same or different, each independently selected from hydrogen, nitro, halogen, amino, acyl, sulfonamide, carboxy, carboxylate, amide, nitrile, hydroxy, carbamyl, thiourea, aminomethyl, cyano, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkylamino, substituted or unsubstituted lower alkylthio, substituted or unsubstituted lower alkylsulfo, substituted or unsubstituted lower alkylamide, substituted or unsubstituted lower aliphatic alkenyloxy, substituted or unsubstituted lower aliphatic alkynyloxy, substituted or unsubstituted aliphatic cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted arylcarbonyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted arylamino, substituted or unsubstituted heteroarylamino, substituted or unsubstituted arylthio, or substituted or unsubstituted heteroarylthio; R3′ and R4′ are methyl, R5′ to R10′ are hydrogen, and R11′ is methyl, R9-R13 are same or different, each independently selected from haloalkyl, haloalkoxy, hydrogen, nitro, halogen, amino, acyl, sulfonamide, carboxy, carboxylate, amide, nitrile, hydroxy, carbamyl, thiourea, aminomethyl, cyano, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkylamino, substituted or unsubstituted lower alkylthio, substituted or unsubstituted lower alkylsulfo, substituted or unsubstituted lower alkylamide, substituted or unsubstituted lower aliphatic alkenyloxy, substituted or unsubstituted lower aliphatic alkynyloxy, substituted or unsubstituted aliphatic cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted arylcarbonyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted arylamino, substituted or unsubstituted heteroarylamino, substituted or unsubstituted arylthio, or substituted or unsubstituted heteroarylthio; Z is O, S or NR14, R14 is selected from hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aliphatic cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; and the condition is that at least one of R9-R13 is haloalkyl or haloalkoxy.