Patent ID: 6638513
Filing Date: 2003-10-28
Classification: A61K,A61P,Y10S

Abstract:
A glycoconjugate comprising substantially homogenous sized Neisseria meningitidis serogroup B (MenB) capsular oligosaccharides in which sialic acid residue N-acetyl groups are replaced with saturated N-propionyl groups,wherein said MenB oligosaccharides are covalently attached to a protein carrier molecule, have an average degree of polymerization (Dp) of 10 to 20, and further comprise a C3-C16 long-chain aliphatic lipid covalently attached thereto; and wherein said glycoconjugate has a saccharide-to-protein ratio ranging from 0.10 to 0.25 by weight, and elicits antibodies that do not bind to the human neuroblastoma cell line CHP-134.