Patent ID: 9193674
Filing Date: 2015-11-24
Classification: C07B,C07C,C07D,Y02A

Abstract:
1. A process for the preparation of compound of general formula I: wherein R R (i). heating a mixture of amine (A) and D-(−)-pantolactone (B) in the ratio ranging from 1:1.5 to 1:2 in a solvent at a temperature in the range of 110 to 150° C. for a period in the range of 16 to 24 hours followed by raising the temperature of the mixture to a temperature in the range of 200-230° C. for a period in the range of 15 to 25 minutes to obtain a crude reaction mixture; wherein R (ii). cooling the crude reaction mixture as obtained in step (i) at a temperature in the range of 25 to 30° C. followed by purifying by silica gel column chromatography to obtain the compound of general formula I.