Patent ID: 6262089
Filing Date: 2001-07-17
Classification: A61P,C07D

Abstract:
A D-proline compound of the formula: ##STR100##whereinR.sup.1 is hydrogen or halogen;X is --(CH.sub.2).sub.n --; --CH(R.sup.2)(CH.sub.2).sub.n --; --CH.sub.2 O(CH.sub.2).sub.n --; --CH.sub.2 NH--; benzyl; --C(R.sup.2).dbd.CH--; --CH.sub.2 CH(OH)--; or thiazol-2,5-diyl;Y 2,6-pyridyl;X' is --(CH.sub.2).sub.n --; --(CH.sub.2).sub.n CH(R.sup.2)--; --(CH.sub.2).sub.n OCH.sub.2 --; --NHCH.sub.2 --; benzyl; --CH.dbd.C(R.sup.2)--; --CH(OH)CH.sub.2 ; or thiazol-2,5-diyl;R.sup.2 is lower alkyl, lower alkoxy, or benzyl;{character pullout} is a single or a double bond; andn is 0-3,or a pharmaceutically acceptable salt, monoester, or diester thereof.