Patent ID: 8491871
Filing Date: 2013-07-23
Classification: G01N

Abstract:
1. A method of determining risk of heart failure in a mammal comprising; i) determining in a biological sample obtained from the mammal the concentration level of each of IL-6, MCP-1, IL-10, VEGF, and EGF biomarkers in the sample; ii) comparing the level of each biomarker in the sample to a median concentration of each of the biomarkers in a given population; iii) determining whether or not the level of each biomarker constitutes a positive result, wherein a positive result is represented by an increase in the concentration of any of IL-6, MCP-1, IL-10 and VEGF and a decrease in the concentration of EGF in the sample as compared with the median concentration; and iv) identifying the mammal as at risk of heart failure on determination of a positive result of at least three of said biomarkers in the sample.