Patent ID: 7910097
Filing Date: 2011-03-22
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting metastasizing tumor cells that CLEVER-1-binding malignant cells from entering lymph nodes in a patient in need of the same, said method comprising administering, to said patient, an agent that inhibits CLEVER-1 mediated endothelial cell binding to said CLEVER-1-binding malignant cells in said patient, wherein said agent is a CLEVER-1 antagonist antibody or a fragment thereof that contains an antigen binding site, and wherein said anti-CLEVER-1 antibody or a fragment thereof binds an epitope on CLEVER-1 recognized by monoclonal antibody 3-266 produced by the hybridoma DSM ACC2519 or monoclonal 3-372 produced by the hybridoma DSM ACC2520.