Patent ID: 6518285
Filing Date: 2003-02-11
Classification: A61P,C07D

Abstract:
A compound of Formula I wherein(a) R3 is selected from H, alkyl, â€”COR4, â€”(CH2)theteroaryl, â€”CHR5R6, â€”(CH2)taryl, â€”SO2NR5R6, and â€”SO2R9; (b) R4 is selected from H, â€”OR5, alkyl, alkylaryl, â€”(CH2)taryl, â€”(CH2)theteroaryl, â€”(CH2)tOR5, â€”(CH2)tNR7R8, â€”CHR5R6, and â€”NR5R6 optionally forming a cyclic amino derivative; (c) R5 and R6 are independently selected from H, alkyl, alkylaryl, haloaryl, â€”(CH2)taryl, â€”(CH2)theteroaryl, and acyl; (d) R7 and R8 are independently selected from H, alkyl, â€”COR9, â€”SO2R9 and â€”CO2R9; and (e) R9 is selected from H, alkyl, aryl and alkylaryl; R2 is selected from C(O)RG and C(O)OR9, R2a is H or acyl with the proviso that when R3 is selected from alkyl, â€”(CH2)taryl, â€”(CH2)theteroaryl, and â€”CHR5R6, R2a is H; X is Nor CH; Y is selected from H, halogen, alkoxy, and alkyl; and t is an integer of 0 to 4; or an optical isomer, enantiomer, diastereomer, racemate or racemic mixture thereof, or a pharmaceutically acceptable salt thereof.