Patent ID: 6110916
Filing Date: 2000-08-29
Classification: A61K,C07C,C07F,C12N,Y10S

Abstract:
A compound having the formula: and salts thereof where:X is N;x is an integer ranging from 1 to about 20;n.sub.i, where i-1 to x, independently of one another, are integers that can have a value ranging from 1 to about 6;r is 0 or 1 with N positively charged when r is 1;R.sub.A and R.sub.B, independently or one another, are selected from the group consisting of H, an alkyl, hydroxyalkyl and thiol-substituted alkyl group having from 1 to 6 carbon atoms except that when x=1, R.sub.A and R.sub.B are not hydrogens;R.sub.1 and R.sub.2, independently of other R.sub.1 and R.sub.2, are selected from the group consisting of alkyl groups having from 1 to about 6 carbon atoms;A.sub.1, independently of other A.sub.1 groups, and A.sub.2 are selected from the group consisting of the groups:(a) a straight-chain or branched alkyl, alkenyl, or alkynyl group having from 2 to about 22 carbon atoms wherein one or more non-neighboring --CH.sub.2 -- groups can be replaced with an O or S atom;(b) a straight-chain or branched alkyl group substituted with one or two OH, SH, NH.sub.2 or amine groups within about 3 carbon atoms of the bond between A.sub.1 or A.sub.2 and N;(c) a substituted straight-chain or branched alkyl, alkenyl or alkynyl group having from 2 to about 22 carbon atoms wherein the substituent is an aromatic, alicyclic heterocyclic or polycyclic ring and wherein one or more of the non-neighboring --CH.sub.2 -- groups of said alkyl, alkenyl or alkynyl group can be substituted with an O or S atom;(d) a-B-L group where B is selected from the group consisting of --CO--, --CO.sub.2 --, --O--C--O--, --CO--NH--, --O--CO--NH--, --O--CH.sub.2 --, --S--CH.sub.2 --, --CH.sub.2 --S--, and --CH.sub.2 -- and L is selected from the group consisting of those groups defined in (a) or (c), above, an aromatic, alicyclic, heterocyclic, and a polycyclic ring moiety; or(e) a --CH(D-L).sub.2 or a --C(D-L).sub.3 group where D is selected from the group --CO--, --CO.sub.2 --, --OCO--, --CO--NH--, --O--CO--NH--, --O--, and --S-- and L is selected from the group consisting of those groups defined in (a) or (c), above, an aromatic, alicyclic, heterocyclic, and a polycyclic ring moiety andwherein two A.sub.1 groups or an A.sub.1 and an A.sub.2 group are covalently linked with one another to form a cyclic moiety.