Patent ID: 7329648
Filing Date: 2008-02-12
Classification: A61K,A61P,C12N

Abstract:
1. A method for increasing the immunostimulatory effect of a CpG-containing oligonucleotide, the method comprising introducing into the oligonucleotide a 2′-5′ internucleoside linkage at a position selected from the group consisting of 3rd nucleoside 5′ to the CpG dinucleotide, 4th nucleoside 5′ to the CpG dinucleotide, 5th nucleoside 5′ to the CpG dinucleotide, 6th nucleoside 5′ to the CpG dinucleotide, 2 nd nucleoside 3′ to the CpG dinucleotide, 3rd nucleoside 3′ to the CpG dinucleotide, 4th nucleoside 3′ to the CpG dinucleotide, 5th nucleoside 3′ to the CpG dinucleotide, 6th nucleoside 3′ to the CpG dinucleotide, and combinations thereof.