Patent ID: 6251910
Filing Date: 2001-06-26
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR18##wherein:R.sup.1 is a C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-8 -cycloalkyl or a phenyl group, each group being optionally substituted by one or more substituents selected from halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11 or C.sub.1-6 alkyl (itself optionally substituted by one or more halogen atoms);R.sup.2 is C.sub.1-8 alkyl optionally substituted by one or more substituents selected from the group consisting of halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11, or C.sub.3-8 -cycloalkyl, aryl (optionally substituted by one or more C.sub.1-6 alkyl groups and/or halogen atoms), and C.sub.1-6 -alkyl;or R.sup.2 is a C.sub.3-8 -cycloalkyl group optionally substituted by one or more substituents selected from the group consisting of halogen, OR.sup.8, NR.sup.9 R.sup.10, SR.sup.11, C.sub.1-6 -alkyl and phenyl, the latter two groups being optionally substituted by one or more substituents selected from the group consisting of halogen, NO.sub.2, C(O)R.sup.8, OR.sup.8, SR.sup.11, NR.sup.12 R.sup.13, 1,3-benzodioxolyl, phenyl and C.sub.1-6 -alkyl the latter two groups being optionally substituted by OR.sup.8, NR.sup.9 R.sup.10 or one or more halogen atoms;one of R.sup.3 and R.sup.4 hydroxy and the other is hydrogen, hydroxy or N.sup.9 R.sup.10 ;R is a group (CR.sup.5 R.sup.6).sub.m OR.sup.7 where m is 0 or 1, R.sup.5 and R.sup.6 are independently hydrogen, C.sub.1-6 alkyl or phenyl the latter two groups being optionally substituted by halogen, and R.sup.7 is hydrogen, C.sub.1-6 alkyl or (CR.sup.5 R.sup.6).sub.n R.sup.14 where R.sup.5 and R.sup.6 are as defined above, n is 1 to 3 and R.sup.14 is COOH, OR.sup.15, NR.sup.16 R.sup.17 or CONR.sup.16 R.sup.17 ;or R is a C.sub.1-4 alkyl or C.sub.2-4 alkenyl group, each of which is substituted by one or more groups selected from the group consisting of .dbd.S, .dbd.O, .dbd.NR.sup.20 and OR.sup.21 and optionally substituted by one or more groups selected from the group consisting of halogen, C.sub.1-4 alkyl, phenyl, SR.sup.21, NO.sub.2 and NR.sup.22 R.sup.23 (where R.sup.21, R.sup.22 and R.sup.23 are independently hydrogen, C.sub.1-4 alkyl or phenyl; R.sup.20 is OR.sup.24 or NR.sup.25 R.sup.26 where R.sup.24 is hydrogen, C.sub.1-4 alkyl or phenyl, and R.sup.25 and R.sup.26 are independently hydrogen, C.sub.1-4 alkyl, aryl, C.sub.1-6 acyl, arylsulphonyl or arylcarbonyl);R.sup.8 is hydrogen, C.sub.1-6 alkyl optionally substituted by halogen or R.sup.8 is phenyl optionally substituted by one or more substituents selected from halogen, NO.sub.2, C(O)R.sup.6, OR.sup.6, SR.sup.9, NR.sup.10 R.sup.11 ;R.sup.9, R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 alkyl;R.sup.12 and R.sup.13 are independently hydrogen, C.sub.1-6 alkyl, C.sub.1-6 acyl, C.sub.1-6 alkyl sulfonyl optionally substituted by halogen, or phenyl sulfonyl optionally substituted by C.sub.1 -C.sub.4 alkyl; andR.sup.15, R.sup.16 and R.sup.17 are independently hydrogen or C.sub.1-6 alkyl;or a pharmaceutically acceptable salt or solvate thereof.