Patent ID: 6555582
Filing Date: 2003-04-29
Classification: A61K,A61P,Y10S

Abstract:
A method of inhibiting hyaluronic acid secretion in cells in an eye comprising:topically applying an effective amount of a synthetic thyroid hormone to an eye, thereby inhibiting hyaluronic acid secretion by cells in the eye, wherein said synthetic thyroid hormone at a concentration of 10 micromolar or less inhibits at least 10% of total hyaluronic acid secretion from cultured human trabecular meshwork cells after three days culture at 37Â° C. compared to human trabecular meshwork cells cultured in the absence of said synthetic thyroid hormone after three days of culture at 37Â° C., and with the proviso that said non-systemically applying does not include topical application of T3 or T4 isolated from naturally occurring tissues.