Patent ID: 6489449
Filing Date: 2002-12-03
Classification: A61K

Abstract:
A peptide that can inhibit the infection of HIV, wherein said peptide comprises:i) 19 amino acids (628th-646th region) of C-terminal helical region of gp41, or ii) 19 amino acids (628th-646th region) of C-terminal helical region of gp41, wherein at least one amino acid has been mutated from the wild type sequence in order to promote a helical structure in the peptide, and helix-capping motifs appended to at least one end of the peptide, wherein the peptide is chosen from: a) a peptide consisting of from 19 to 27 amino acids; and b) a bivalent peptide with two symmetrical halves each consisting of from 24 to 26 amino acids, joined by an amino acid.