Patent ID: 8879058
Filing Date: 2014-11-04
Classification: A61B,G01J,G02B

Abstract:
1. A miniaturized multi modal imaging system, comprising: A miniaturized multi modal imaging system, a laser delivery subsystem operates to generate an excitation signal in one of two forms, a first form having a pump beam and a second form having a pump beam combined with a Stokes beam, where the laser delivery subsystem includes a first prechirp unit disposed in the pump path and operable to compensate the pump beam for dispersion; a second prechirp unit disposed in the Stokes path and operable to compensate the Stokes beam for dispersion; and an optical element configured to receive both the pump beam and the Stokes beam and operates to form the excitation signal from the pump beam and Stokes beam a scanning mechanism configured to receive the excitation signal and operates to direct the excitation signal in a given direction towards a sample; an optics subsystem configured to receive the excitation signal from the scanning mechanism and focus the excitation signal onto the sample, wherein the optics subsystem includes a field lens, a front end objective lens and at least one relay lens interposed between the field lens and the front end objective lens, such that the relay lens images the excitation signal from the scanning mechanism onto the front end objective lens and each lens is comprised of at least two different types of glass which operate to compensate for chromatic aberration in the excitation signal; an optical fiber that optically couples the laser delivery subsystem to the scanning mechanism; a detector configured to receive an emission resulting from non-linear interaction of the excitation signal with the sample; and a dichroic mirror disposed between the scanning mechanism and the optics subsystem, the dichroic mirror configured to receive the emission from the sample in a direction opposite the given direction and direct the emission along a collection path to the detector; and a controller interfaced with the laser delivery subsystem, wherein the controller, in a first mode, controls the laser delivery subsystem to output an excitation signal having only a pump beam and, in a second mode, controls the laser delivery subsystem to output an excitation signal having a pump beam combined with a Stokes beam.