Patent ID: 6818645
Filing Date: 2004-11-16
Classification: A61P,C07D

Abstract:
A compound of Formula I wherein:R1, and R2 are independently in each occurrence hydrogen, halogen, (C1-6)-alkyl, â€”ORâ€², â€”SRâ€², â€”NRâ€²Râ€³, â€”SORâ€², â€”SO2Râ€², â€”COORâ€², â€”OCORâ€², â€”OCONRâ€²Râ€³, â€”OSO2Râ€², â€”OSO2NRâ€²Râ€³; â€”NRâ€²SO2Râ€³, â€”NRâ€²CORâ€³, â€”SO2NRâ€²Râ€³, â€”SO2(CH2)1-3CONRâ€²Râ€³, â€”CONRâ€²Râ€³, cyano, haloalkyl, or nitro; Râ€² and Râ€³ are independently in each occurrence hydrogen, (C1-6)-alkyl, substituted lower alkyl, aryl, heterocyclyl, heteroaryl, aryl-(C1-3)-alkyl, heteroaryl-(C1-3)-alkyl, heterocyclyl-(C1-3)-alkyl, cycloalkylalkyl, cycloalkyl, or Râ€² and Râ€³ together with the nitrogen they are attached may also form a 5- to 7-membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O)0-2; R3 is independently in each occurrence (C1-6) alkyl, (C1-6) alkenyl, (C1-6) alkynyl, or cycloalkyl; R4 is hydrogen, (C1-6)-alkyl, haloalkyl, aryl(C1-6)alkyl, heteroaryl(C1-6)alkyl, â€”(C1-6)â€”CRâ€²Râ€²Râ€², â€”COORâ€², â€”SO2Râ€², â€”C(O)Râ€², â€”SO2(CH2)0-3NRâ€²Râ€³, â€”CONRâ€²Râ€³, or â€”PO(ORâ€²)2, wherein Râ€² and Râ€³ are as defined above; â€œsubstituted lower alkylâ€  means the lower alkyl having one to three substituents, selected from the group consisting of hydroxyl, alkoxy, amino, amido, carboxyl, ncyl, halogen, cyano, nitro and thiol; â€œheteroarylâ€  means the monovalent aromatic cyclic radical having one to three rings of four to eight atoms per ring, incorporating one or two heteroatoms (chosen from nitrogen, oxygen or sulfur), within the ring which can optionally be substituted with one or two substituents selected from the group consisting of hydroxy, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, alkylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; â€œheterocyclylâ€  means the monovalent saturated cyclic radical, consisting of one or two rings, of three to eight atoms per ring, incorporating one or more ring heteroatoms (chosen from N,O or S(O)0-2), and which can optionally be substituted with one or two substituents selected from the group consisting of hydroxy, oxo, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; â€œcycloalkylâ€  means the monovalent saturated carbocyclic radical consisting or one or two rings, of three to eight carbons per ring, which can optionally be substituted with one or two substitutents, selected from the group consisting of hydroxy, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; p is an integer from 1 to 3 inclusive; n is an integer from 1 to 6 inclusive; and, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof.