Patent ID: 6358994
Filing Date: 2002-03-19
Classification: A61P,C07D

Abstract:
A compound of the formula wherein:R1 and R2 are independently hydrogen, halo, C1-C6 alkyl, hydroxy, or C1-C6 alkoxy; R5, R6, and R7, are independently hydrogen, halo, C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl, or hydroxy; R3 is hydrogen, C2-C7 alkanoyl, glycyl, or dimethylglycyl; n is 1-6; D is â€”S(O)mâ€”, â€”NHâ€”, â€”C(O)â€”, or â€”Oâ€”, m is 0, 1, or 2; R8 and R9 are independently hydrogen, hydroxy, substituted C1-C6 alkyl, substituted C1-C6 alkoxy, C1-C6 alkylthio, C2-C7 alkoxycarbonyl(C1-C6 alkylenyl)-, C2-C7 alkanoyloxy, trifluoromethoxy, trichloromethoxy, C1-C6 alkylthio, formyl, cyano, R10R11N(C1-C6 alkylenyl)-, pyrrolyl, pyrazolinyl, triazolyl, imidazolyl, tetrazolyl, thiazolyl, thiazolinyl, thiadiazolyl, thiadiazolinyl, piperidyl, pyrrolidyl, morpholinyl, morpholinocarbonyl, hexamethyleneiminyl, methylsulfonyl, methylsulfinyl, phenoxy, benzyloxy, carboxy, carbamoyl, or C2-C7 alkylcarbamoyl(C1-C6 alkylenyl)-, R10 and R11 are independently hydrogen or C1-C6 alkyl, said substituted C1-C6 alkyl or substituted C1-C6 alkoxy groups being substituted with one, two, or three moieties selected from the group consisting of hydroxy, acetyl, oxo, halo, cyano, amino, nitro, carboxy, carbamoyl, and thiol; or R8 and R9 can combine, together with the benzo ring to which they are attached, to form a naphthyl, dihydronaphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 2-coumaranonyl, 3-coumaranonyl, benzothiazolyl, benzimidazolyl, indolyl, benzothienyl, benzofuryl, 2,3-dihydrobenzofuryl, indolinyl, or 2,3-dihydrobenzothienyl group, which can be attached to D at any position of the bicyclic group; with the proviso that when D is â€”Oâ€” or when m=0, R8 and R9 cannot both be hydrogen; or a pharmaceutically acceptable salt or solvate thereof.