Patent ID: 6153775
Filing Date: 2000-11-28
Classification: A61K,C07C,C07F

Abstract:
A ligand of formula: where:A is N, CR.sup.1, P, P.dbd.O, cis,cis,cis-1,3,5-trisubstituted-cyclohexane or an N,N',N""-trisubstituted-triaza 9 to 14 membered macrocyclic ring;L.sup.1, L.sup.2, L.sup.3 are linker groups which are independently chosen from C.sub.1-4 alkylene, C.sub.4-6 cycloalkylene or C.sub.4-6 o-arylene;Y.sup.1, Y.sup.2, Y.sub.3 are independently chosen from --NH.sub.2, --B(.dbd.O)OZ, --N.dbd.CR--B(.dbd.O)OZ, --NR--CR.sub.2 --B(.dbd.O)OZ, --N[CR.sub.2 --B(.dbd.O)Q].sub.2 and --O--CR.sub.2 --B(.dbd.O)OZ where B is C or PR.sup.2, each Q is independently --OZ or --NR.sub.2 and Z is H or a counter-ion;each R and R.sup.1 group is independently chosen from H, C.sub.1-5 alkyl, C.sub.1-5 alkoxyalkyl, C.sub.1-5 hydroxyalkyl, C.sub.1-5 aminoalkyl, C.sub.5-10 aryl or C.sub.1-8 fluoroalkyl;R.sup.2 is OH, C.sub.1-6 alkyl, C.sub.1-8 alkoxyalkyl, C.sub.1-6 fluoroalkyl, C.sub.1-10 alkoxy or C.sub.5-10 aryl;with the proviso that at least one of Y.sup.1, Y.sup.2 and Y.sup.3 is --N.dbd.CR--B(.dbd.O)OZ.