Patent ID: 9168568
Filing Date: 2015-10-27
Classification: B01L,B07C,G01N

Abstract:
1. A particle manipulation system, comprising: a sample channel, a sort channel and a waste channel in fluid communication with one another and formed in a surface of a substrate, wherein a flow in the sample channel is substantially parallel to the surface, and wherein the sample channel flows to at least one of the sort channel and the waste channel when the flow is forward; an interrogation means disposed in the sample channel, wherein target particles provide detection signals; a microfabricated particle sorting mechanism which moves in a plane parallel to the surface, and directs the target particles from the sample channel into the waste channel when the microfabricated particle sorting mechanism is in a first position, and which directs the other particles into the sort channel when in a second position; and a fluid control means for controlling a direction and rate of fluid flow in the channels, wherein the fluid control means reverses the flow from at least one of the sort channel and the waste channel back to the sample channel, such that the fluid passes through the interrogation region and the microfabricated particle sorting mechanism a plurality of times and wherein the microfabricated particle sorting mechanism moves from the first position to the second position in response to a force, and wherein the motion is substantially in a plane parallel to the surface of the substrate and wherein at least one of the sort channel and the waste channel is substantially orthogonal to the surface and directly below at least a portion of the microfabricated particle sorting mechanism over at least a portion of its motion.