Patent ID: 6545001
Filing Date: 2003-04-08
Classification: A61P,C07D,C07H,C40B,Y02P

Abstract:
A compound wherein said compound is a cis-nucleoside of formula (I): or a pharmaceutically acceptable salt thereof,wherein: n is 1 or 2; R4 is H, COOH, CONH2, OH, SH, NH2, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, or CORa; Ra is a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or COORb; Rb is a C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; R3 is H or a C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl; X is H, monophosphate, diphosphate, triphosphate, carbonyl substituted with a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, or Rc is in each case independently, H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or a hydroxy protecting group selected from acetyl-2-thioethyl ester, pivaloyloxymethyl ester and isopropyloxycarbonyloxymethyl ester; and wherein said nucleoside is present in the (âˆ’) enantiomer form and is at least 95% free of the (+) enantiomer form.