Patent ID: 6627636
Filing Date: 2003-09-30
Classification: A61P,C07D

Abstract:
A compound having the structure whereinX is O, S, SO, SO2 or NR7; Z is â€ƒalso referred to as the 3-lactone; n is 0 or 1; R1 and R2 are the same or different and are independently selected from alkyl, arylalkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, heteroaryl or cycloheteroalkyl; R3 is H or lower alkyl or a metal ion R4 is H, halogen, CF3, hydroxy, alkyl, alkoxy, carboxyl, carboxyalkyl-, aminoalkyl, amino, alkanoylamino, aroylamino, cyano, alkoxyCON(R7d)-, R7fR7gNCO2â€”, R7fR7gNCOâ€”, R7eSO2N(R7d)-, R7fR7gNSO2N(R7d)-, R7eOCO2 or R7eOCO; R7 is H, alkyl, aryl, alkanoyl, aroyl or alkoxycarbonyl, R7aSO2â€”, R7bR7cNSO2â€” or R7bR7cNCOâ€”; R7a and R7e are the same or different and are independently selected from alkyl, arylalkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, heteroaryl or cycloheteroalkyl; R7b and R7c, and R7f and R7g, and R7d are the same or different and are independently selected from H, alkyl, arylalkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, heteroaryl or cycloheteroalkyl; R8 is H or lower alkyl; R9 and R10 are the same or different and are independently selected from H or alkyl; or where at least one of R9 and R10 is alkyl, R9 and R10 may be taken together with the carbon to which they are attached to form a 3 to 7 membered spirocyclic ring; and  represents a single bond or a double bond (which may be cis or trans); or a pharmaceutically acceptable salt thereof (where R3 is H), or an ester thereof, or a stereoisomer thereof.