Patent ID: 6476041
Filing Date: 2002-11-05
Classification: A61P,C07D

Abstract:
A compound having the formula: or a pharmaceutically acceptable salt thereof, whereinR1 is 2-benzimidazole, 2-imidazopyridine, purine, or 2-quinazoline, each optionally substituted with one to five substituents, each substituent independently being chloro, fluoro, bromo, C1-C4alkyl, trifluoromethyl, C1-C4alkylsulfonamide, hydroxy, or carboxy; R2 is phenyl, optionally substituted with one to five substituents, each substituent independently being chloro, fluoro, bromo, C1-C4alkyl, trifluoromethyl, C1-C4alkylsulfonamide, hydroxy, or carboxy; when R1 is 2-benzimidazole, L1 or L2 is not C1-C2alkyl, except when R1 is hydroxy-substituted 2-benzimidazole, L1 or L2 includes C1-C2alkyl; L1 and L2 are independently C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C4alkoxy, aminoC1-C4alkyl, hydroxyC1-C4alkyl, carbonyl, cycloC3-C6alkyl or aminocarbonyl; and optionally substituted at any of the 2, 3, 5, or 6 positions independently with X, wherein X is hydroxy, amino, C1-C4alkylamino, di(C1-C4)alkylamino, C1-C4alkyl, C1-C4alkylester, â€”OCOOC1-C4alkyl, â€”NHCOOC1-C4alkyl, â€”OCONHC1-C4alkyl, C1-C4alkylcarbonate, or C1-C4alkylether.