Patent ID: 9140708
Filing Date: 2015-09-22
Classification: A61P,C07K,G01N

Abstract:
1. A method of treating enamel erosion of dietary etiology in a mammal, comprising: identifying a mammal that is in need of treatment for dietary enamel erosion; and administering to the oral cavity of said mammal an effective amount of an agent or product that reduces dentin or enamel erosion; wherein: said identifying is performed by a process comprising the steps of: a. obtaining a sample of whole mouth saliva from the oral cavity of the mammal; b. measuring the concentration of one or more of the following biomarkers: c. comparing the mucin B concentration; the carbonic anhydrase 6 concentration; wherein said control value is the concentration of said biomarker in a whole mouth saliva sample taken from the oral cavity of a mammal not suffering from erosion; and wherein a lower mucin 5B concentration relative to said control value for mucin 5B indicates a heightened susceptibility to enamel erosion; wherein a lower carbonic anhydrase 6 concentration relative to said control value for carbonic anhydrase 6 indicates a heightened susceptibility to enamel erosion; and wherein a higher statherin concentration relative to a control value for statherin indicates a heightened susceptibility to enamel erosion.