Patent ID: 8652491
Filing Date: 2014-02-18
Classification: A61K,A61P

Abstract:
1. A transdermal or transmucosal composition comprising: oxybutynin as an anti-cholinergic agent in an amount between 1 to 2% by weight of the composition; and a delivery vehicle comprising a C2 to C4 alkanol or a mixture thereof present in an amount of 45 to 63%, a polyalcohol present in an amount of 1 to 5% selected from the group consisting of propylene glycol, dipropylene glycol, polyethylene glycol, glycerin, and mixtures thereof, a monoalkyl ether of diethylene glycol or a mixture thereof present in an amount of 2 to 10%, and water present in an amount of about 10 to about 25%; wherein all percentages are calculated by weight of the composition, and the weight ratio of the polyalcohol to the monoalkyl ether of diethylene glycol is between 1:2 and 1:10 to deliver the anticholinergic agent to a subject who receives the composition on a skin surface; and wherein the composition is substantially free of additional permeation enhancers to avoid deeper penetration of the anti-cholinergic agent and undesirable odor and irritation effects caused by permeation enhancers of conventional fatty compounds during use of the composition.