Patent ID: 6248238
Filing Date: 2001-06-19
Classification: A61M,B01D

Abstract:
Medical apparatus for the extracorporeal treatment of blood or plasma, comprising a semi-permeable membrane comprising at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges, wherein the semi-permeable membrane has a negative electric charge density greater than 100 .mu.eq per ml of swollen polymer wherein, before sterilization of the apparatus, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, wherein the anti-protease agent is present in sufficient quantities to prevent activation of the kallikrein-kinin system during treatment of blood or plasma, said agent being bound in the membrane by bulk adsorption or semi-bulk adsorption and/or being bound by an ionic interaction with the electronegative sites of the membrane.