Patent ID: 8981053
Filing Date: 2015-03-17
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A synthetic peptide molecule that specifically binds the FXYD2-gamma-a isoform of pancreatic beta cells, wherein the peptide molecule comprises an amino acid sequence of: (a) X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-X25 (SEQ ID NO: 1) and the functional equivalents thereof, wherein X1 is leucine or isoleucine, X2 is proline, X3 is leucine or isoleucine, X4 is serine or threonine, X5 is arginine, lysine or histidine, X6 is histidine, arginine or lysine, X7 is tyrosine, X8, X9 and X10 are glycine, X11 is serine or threonine, X12 is valine, leucine or isoleucine, X13 is proline, X14 is phenylalanine or leucine, X15 is tyrosine, X16 is serine or threonine, X17 is histidine, arginine or lysine, X18 is serine or threonine, X19 is asparagine or glutamine, X20 is threonine or serine, X21 and X22 are histidine, arginine or lysine, X23 is threonine or serine, X24 is serine or threonine, X25 is methionine or cysteine; or (b) X26-X27-X28-X29-X30-X31-X32-G-G-G-S-V-P-F-Y-S-H-S-X33-X34-X35-X36-X37-X38-X39 (SEQ ID NO: 3) and the functional equivalents thereof, wherein X26 is histidine arginine or lysine, X27 is aspartic acid or glutamic acid, X28 is arginine, lysine or histidine, X29 is leucine or isoleucine, X30 is lysine, arginine or histidine, X31 is serine or threonine, X32 is histidine, lysine or arginine, X33 is isoleucine or leucine, X34 is histidine, arginine or lysine, X35 is alanine, X36 is histidine, lysine or arginine, X37 is leucine or isoleucine, X38 is proline, X39 is glutamine or asparagine.