Patent ID: 8043829
Filing Date: 2011-10-25
Classification: A61K,A61P,C07K

Abstract:
1. A DNA encoding a recombinant fusion protein, wherein the fusion protein comprises a ShK toxin peptide, wherein said fusion protein comprises, in the N-terminal to C-terminal direction: (a) an immunoglobulin or a portion thereof comprising: (b) a peptidyl linker 4 to 40 amino acid residues long and comprising at least one protease cleavage site; and (c) an immunoglobulin Fc domain or a CH2 domain thereof, wherein if (a) comprises (ii), (c) is a second immunoglobulin Fc domain or a CH2 domain thereof; and wherein the amino acid sequence of the ShK toxin peptide is SEQ ID NO:914, SEQ ID NO:915, SEQ ID NO:916, or SEQ ID NO:917, covalently linked to the N-terminal end of (a) or C-terminal end of (c).