Patent ID: 8709734
Filing Date: 2014-04-29
Classification: G01N

Abstract:
1. A method of identifying an agent that modulates the function of GPR1, the method comprising: a) contacting a GPR1 polypeptide with a Humanin polypeptide in the presence or absence of a candidate modulator under conditions permitting the interaction of the Humanin polypeptide with the GPR1 polypeptide; and b) measuring the interaction of the GPR1 polypeptide with the Humanin polypeptide, wherein an increase or a decrease in interaction in the presence of the candidate modulator, relative to the interaction in the absence of the candidate modulator, identifies the candidate modulator as an agent that modulates the function of GPR1; wherein the Humanin polypeptide is a polypeptide having at least 95% sequence identity to polypeptides of SEQ ID NO: 12, 13, 14 or 15 that specifically binds to and/or activates a signaling activity of a GPR1 polypeptide having the sequence of SEQ ID NO: 2.