Patent ID: 6147188
Filing Date: 2000-11-14
Classification: A61K,A61P,C07D

Abstract:
Cathepsin or calpain inhibitors of the formula: ##STR52## where B is H or an N-terminal blocking group;R.sub.1 is an amino acid side chain of an amino acid other than Asp;each P.sub.n is an amino acid residue, or is a heterocyclic replacement of the amino acid;m is 0 or a positive integer;R.sub.4 is a hydroxyl, alkoxyl, acyl, hydrogen, alkyl or phenyl;R.sub.5 and R.sub.6 are jointly a carboxyl group or a double bond terminating in an alkyl or an aryl group, or are independently acyl, aryl or heteroaryl if R.sub.4 is hydrogen, alkyl or phenyl, or are independently acyl, alkyl, hydrogen, aryl or heteroaryl otherwise; and X is N, S, O or CH.sub.2.