Patent ID: 6750239
Filing Date: 2004-06-15
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable derivative thereof, whereinB is a phenyl ring having a substituent â€”Lâ€”A and 0-3 R2 substituents; L is an optionally substituted C1-C6 alkylidene chain; wherein at least 1 and optionally up to 2 methylene units are replaced by â€”Oâ€”, â€”C(O)â€”, â€”C(O)C(O)â€”,â€”C(O)NR8â€”, â€”C(O)NR8NR8â€”, â€”CO2â€”, â€”OC(O)â€”, â€”NR8CO2â€”, â€”NR8C(O)NR8â€”, â€”OC(O)NR â€”, â€”NR8â€”, â€”NR8NR8â€”, â€”NR8COâ€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”SO2NR8â€”, â€”NR8SO2â€”, â€”NR8SO2NR8â€”, â€”N(R8)Oâ€”, or â€”ON(R8)â€”; Q is an optionally substituted C1-C6 alkylidene chain, wherein up to two methylene units are replaced by â€”C(O)â€”, â€”C(O)C(O)â€”, â€”C(O)NR7â€”, â€”C(O)NR7NR7â€”, â€”CO2â€”, â€”OC(O)â€”, â€”NR7CO2â€”, â€”Oâ€”, â€”NR7C(O)NR7â€”, â€”OC(O)NR7â€”, â€”NR7NR7â€”, â€”NR7C(O)â€”, â€”Sâ€”, â€”SOâ€”, â€”SO2â€”, â€”NR7â€”, â€”SO2NR7â€”, â€”NR7SO2â€”, or â€”NR7SO2NR7â€”; n is zero or one; R1 is hydrogen, R, fluoro, â€”CN, N(R7)2, OR7, NR7C(O)R7, NR7C(O)N(R7)2, C(O)N(R7)2, SO2R7, NR7SO2R7, or SO2N (R7)2; each R2 is independently selected from R, OH, OR, SH, SR, nitro, N(R7)2, halogen, CF3, or cyano; R3 is hydrogen, R, OH, OR, N(R7)2, fluoro, or CN; R4 is selected from â€”(CH2)yR6, â€”(CH2)yR10, â€”(CH2)yCH(R6)2, â€”(CH2)yCH(R10)2, â€”(CH2)yCH(R10)CH(R6)2, â€”(CH2)yCH(R10)(R6), â€”N(R5)2, or â€”NR5(CH2)yN(R5)2; each R is independently selected from an optionally substituted group selected from C1-6 aliphatic or C6-10 aryl; each R5 is independently selected from R, â€”(CH2)yR6, â€”(CH2)yCH(R6)2, R7 â€”C(O)R7, â€”CO2R7, â€”C(O)N(R7)2, or â€”SO2R7; each y is independently 0-6; each R6 is independently selected from hydrogen, R, â€”(CH2)yR, â€”OH, â€”OR, â€”CO2R, â€”(CH2)yN(R7)2, â€”N(R7)2, â€”OR7, â€”SR7, â€”NR7C(O)R7, â€”NR7C(O)N(R7)2, â€”C(O)N(R7)2, â€”SO2R7, â€”NR7SO2R7, â€”C(O)R7, â€”CN, or â€”SO2N(R7)2; each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group; each R8 is independently selected from hydrogen, R, â€”(CH2)yR9, â€”(CH2)yCH(R9)2, â€”(CH2)yC(O)R9, R9, or R7; each R9 is independently selected from hydrogen, R, â€”OH, â€”OR, â€”SR, â€”S(O)R, â€”SO2R, â€”C(O)R6, â€”CO2R6, NR2, halo, cyano, or nitro; each R10 is independently selected from R, â€”(CH2)wOR7, â€”(CH2)wN(R5)2, or â€”(CH2)wSR7; and each w is independently 0-4; provided that when Qnâ€”R4 is R1 is H, and R3 is H, and R2 is a meta substituent Cl, then â€”Lâ€”A is not a para substituent or andwhen Qnâ€”R4 is R1 is NH2, R2 is a meta substituent Cl, and R3 is H, then â€”Lâ€”A is not a para substituent