Patent ID: 6403588
Filing Date: 2002-06-11
Classification: A61K,A61P,C07D

Abstract:
An imidazolidine derivative represented by formula (I) or salts thereof; wherein R1 represents â€”H, -a lower alkyl, -a lower alkenyl, lower alkyl, -a cycloatkyl, -a cycloalkenyl, -a halogen, â€”NO2, â€”CN, -a halogenated lower alkyl, â€”ORa, â€”SRa, â€”SO2Ra, â€”SORa, â€”CO2Ra, â€”COâ€”Ra, -an aryl, -a lower alkylene-an aryl, â€”O-a lower alkylene-an aryl, â€”CONRaRb, â€”CO-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”SO2NRaRb, â€”SO2-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”SO3H, -(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”NRaRb, â€”CONRa-a lower alcylene-ORb, â€”CONRa-a lower alkylene-NRbRc, â€”CONRa-a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”O-a lower alkylene-ORa, â€”O-a lower alkylene-O-a lower alkylene-ORa, â€”O-a lower alkylene-NRaRb, â€”O-a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”O-a lower alkylene-O-a lower alkylene-NRaRb, â€”O-a lower alkylene-O-a lower alkylene-(a nitrogen-containing saturated hetermcyclic group which may be substituted by a lower alkyl group), â€”O-a lower alkylene-NRc-a lower alkylene-NRaRb, â€”O-a lower alkylene-NRc-a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”OCOâ€”NRaRb, â€”OCO-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”NRa-SO2Rb, â€”NRc-a lower alkylene-NRaRb, â€”NRc-a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), â€”N(a lower alkylene-NRaRb)2, â€”N(a lower alkylene-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group))2, â€”CONRaâ€”ORb, â€”NRaâ€”CORb, â€”NRaâ€”COâ€”NRbRc, â€”NRaâ€”CO-(a nitrogen-containing saturated heterocyclic group which may be substituted by a lower alkyl group), or â€”OCORa; Ra, Rb and Rc which may be the same or different, represent â€”H, -a lower alkyl or -an aryl; T represents N or CR1a, U represents N or CR3; N represents an integer, 1, 2 or 3; in Y1 . . . Y2 . . . Y3, . . . represents a single bond on one side and a single or double bond on the other side, Y1 represents CR5 or CR5aR5b, Y2 represents N, NH, CR4a or CR4bR4c, and Y3 represents NR6, CR4d or CR4eR4f, whereas Y3 represents NR6 when Y2 represents CR4a or CR4bR4c; X represents S, SO or SO2; â€œAâ€  represents a linkage, a lower alkylene, a lower alkenylene or a lower alkenylene; R2 represents -a lower alkyl which may have one or more substituents, -a lower alkenyl which may have one or more subsituents, -a lower alkynyl which may have one or more subsituents, -a cycloalkyl which may have one or more subsituents, -a cycloalkenyl which may have one or more subsituents, â€”N&boxH;O, -an aryl which may have one or more subsituents, or -a heteroaryl which may have one or more subsituents; R1a, R3, R4a, R4b, R4c, R4d, R4e, R4f, R5a, and R5b, which may be the same or different, represent a group defined by R1, whereas R4b and R4c, R4c and R4f, or R5a and R5b may be combined with each other to form an oxo group (&boxH;O); R5 and R6 which may be the same or different, represent â€”H, -a lower alkyl which may have one or more subsituents, -a lower alkenyl which may have one or more subsituents, -a lower alkynyl which may have one or more subsituents.