Patent ID: 7195890
Filing Date: 2007-03-27
Classification: A61K

Abstract:
1. A method for identifying an agent which primes a cell for preconditioning and/or inducing preconditioning of a cell, tissue, or organ comprising: a) obtaining a cell, tissue, or organ that comprises an endogenous preconditioning protein, selected from the group consisting of isocitrate dehydrogenase NAD+ specific subunit alpha, succinyl CoA ligase, 23 kDa mitochondrial precursor subunit of Complex I, 24 kDa mitochondrial precursor subunit of Complex I, 30 kDa mitochondrial precursor subunit of Complex I, δ chain of the F b) providing the agent to said cell, tissue, or organ; c) detecting an increase in abundance of the preconditioning protein in the presence of the agent as compared to the abundance of preconditioning protein in the absence of the agent; and thereby d) identifying an agent that primes a cell for preconditioning and/or inducing preconditioning of a cell, tissue, or organ.