Patent ID: 6653284
Filing Date: 2003-11-25
Classification: A61K,A61P,C07K,Y10S

Abstract:
A pharmaceutical composition, comprising:(a) a KGF-2 polypeptide in a concentration range of about 0.02 to about 40 mg/ml (w/v), wherein said KGF-2 polypeptide is selected from the group consisting of Ala (39)â€”Ser (208); Pro (47)â€”Ser (208); Ala (63)â€”Ser (208); Ser (69)â€”Ser (208); Val (77)â€”Ser (208); Glu (93)â€”Ser (208); Glu (104)â€”Ser (208); Val (123)-Ser (208); Gly (138)â€”Ser (208); Met (1)â€”Lys (153); Thr (36)â€”Lys (153); and Cys (37)â€”Lys (153) of SEQ ID NO:2; (b) a buffer having a buffering capacity of between about pH 5.0 and about pH 8.0 at a concentration range of about 5 mM to about 50 mM; (c) a diluent to bring the composition to a designated volume; (d) a chelating agent at a concentration range of about 0.1 mM to about 10 mM; and (e) NaCl at a concentration range of about 0.01 mM to about 150 mM, or a reaction product of (a), (b), (c), (d), (e) or any combination thereof formed by admixing the ingredients of said composition together.