Patent ID: 6066450
Filing Date: 2000-05-23
Classification: C12Q

Abstract:
A method of identifying an animal predisposed or susceptible to osteoporosis, said method comprising determining the presence of a C/F genotype or an F/F genotype in the 3' flanking region of an IL-6 gene in said animal, wherein said C/F genotype is correlated with decreased risk of osteoporosis and the F/F genotype is correlated with increased risk of osteoporosis, and wherein when said 3' flanking region of an IL-6 gene is amplified by PCR using nucleic acid primers having the nucleotide sequences as set forth in SEQ ID NO:1 and SEQ ID NO:2, said C/F genotype is indicated by obtaining DNA amplimers of sizes 695 bp and 675 bp and said F/F genotype is indicated by obtaining a DNA amplimer of size 675 bp.