Patent ID: 8962579
Filing Date: 2015-02-24
Classification: A61K,A61P,C12N

Abstract:
1. A polynucleotide consisting of a nucleotide sequence of the formula: 5′-N n TGCN m -3′, wherein 5′-TGC-3′ is a TLR7-inhibitory sequence located at or 1 nucleotide from the 5′ end of the polynucleotide, each N is a nucleotide, n is 0 or 1, m is an integer from 5 to 50, and N m comprises 5′- S 1 S 2 S 3 S 4 -3′, wherein 5′- S 1 S 2 S 3 S 4 -3′ is a TLR9-inhibitory sequence, at least one of S 1 , S 2 , S 3 , and S 4 is inosine, wherein remaining S 1 , S 2 , S 3 , and S 4 , if any, are G, and wherein the polynucleotide does not comprise a CG dinucleotide.