Patent ID: 6204293
Filing Date: 2001-03-20
Classification: C07B,C07C,C07D,C07F

Abstract:
A compound having Formula I ##STR3642##or a pharmaceutically acceptable salt thereof, whereinR.sub.1 is phenyl, wherein the phenyl is unsubstituted or substituted with loweralkyl;R.sub.2 is selected from the group consisting of --L.sub.11 --C(R.sub.14)(R.sub.v)--C(O)OR.sub.15 and --C(O)NH--CH(R.sub.14)--C(O)NHSO.sub.2 R.sub.16 ; whereinL.sub.11 is --C(O)--;R.sub.v is hydrogen;R.sub.14 is selected from the group consisting of alkylsulfonylalkyl and thioalkoxyalkyl;R.sub.15 is selected from the group consisting of hydrogen and loweralkyl;R.sub.16 is aryl, wherein the aryl is unsubstituted or substituted with a substituent selected from the group consisting of loweralkyl and halogen;L.sub.1 is --L.sub.4 --O--L.sub.5 --, whereinL.sub.4 is absent or selected from the group consisting of C.sub.1 -to-C.sub.10 -alkylene and C.sub.2 -to-C.sub.16 -alkenylene, wherein the alkylene and alkenylene groups are unsubstituted or substituted with 1, 2 or 3 substitutents independently selected from the group consisting of alkoxyalkyl, alkyl[S(O).sub.q ]alkyl, arylalkyl, hydroxyl, cycloalkoxyalkyl, cycloalkylalkyl, oxo, and arylalkoxyalkyl, wherein the arylalkoxyalkyl is unsubstituted or substituted with alkoxy;q is zero, one or two;L.sub.5 is absent or selected from the group consisting of C.sub.1 -to-C.sub.10 -alkylene and C.sub.2 -to-C.sub.16 -alkenylene wherein the alkylene and alkenylene is unsubstituted or substituted as defined previously;with the proviso that at least one of L.sub.4 and L.sub.5 is not absent;Z is a covalent bond;R.sub.3 is selected from the group consisting of aryl, cycloalkyl, and cycloalkenyl, wherein the aryl is unsubstituted or substituted with a substituent selected from the group consisting of alkanoyl, alkoxyalkyl, alkoxycarbonyl, arylalkyl, aryl, aryloxy, (aryl)oyl, carboxaldehyde, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, halogen, haloalkyl, hydroxyl, hydroxyalkyl, loweralkyl, nitro, --NRR', thioalkoxy, and alkoxy, wherein the alkoxy is unsubstituted or substituted with cycloalkyl; whereinR and R' are independently selected from the group consisting of hydrogen and loweralkyl; andR.sub.4 is selected from the group consisting of hydrogen and arylalkyl.