Patent ID: 6548523
Filing Date: 2003-04-15
Classification: A61P,C07C,C07D

Abstract:
A process for preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: wherein R1 is an aryl, pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group, optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C1-6alkoxy, C1-6alkyl, hydroxymethyl, trifluoromethyl, â€”NR6R6, and â€”NHSO2R6, where each R6 is independently hydrogen or C1-4alkyl;R2 is hydrogen or C1-6alkyl; R3 is CO2R7 where R7 is hydrogen or C1-6alkyl; R4 and R5 are independently hydrogen, C1-6alkyl, or â€”CO2C1-6alkyl; and Y is N or OH comprising the step of preparing a diamide of Formula (II) or a pharmaceutically acceptable salt thereof: wherein R1 is an aryl, pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group, optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C1-6alkoxy, C1-6alkyl, hydroxymethyl, trifluoromethyl, â€”NR6R6, and â€”NHSO2R6, where each R6 is independently hydrogen or C1-4alkyl;R2 is hydrogen or C1-6alkyl; R3 is CO2R7 where R7 is C1-6alkyl; R4 and R5 are independently hydrogen, C1-6alkyl, or â€”CO2C1-6alkyl; and Y is N or CH.