Patent ID: 6812331
Filing Date: 2004-11-02
Classification: A61P,C07H

Abstract:
A compound having a formula selected from the group consisting of wherein R2 is hydrogen or halogen, R3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, ORâ€²4 is a protected â€”OH, Râ€³4 is hydrogen or Râ€²4 and Râ€³4 together with the carbons to which they are attached form R5 is hydrogen or alkyl of 1 to 4 carbon atoms, R6 is alkyl or â€”CH2â€”O-alkyl of up to 8 carbon atoms, R7 is hydrogen or alkyl or 1 to 8 carbon atoms, R8 and R9 are individually â€”OH or protected â€”OH, Z is hydrogen or X is selected from the group consisting of &boxH;O, &boxH;N-Nalk and &boxH;NOAlk2, alk and alk2 are individually alkyl of 1 to 12 carbon atoms optionally interrupted by a member of the group consisting of oxygen, sulfur and nitrogen and unsubstituted or substituted by at least one halogen or a group Re and Rf are individually hydrogen or alkyl of 1 to 6 carbon atoms or taken with the nitrogen form a heterocycle optionally containing a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and R1 is selected from the group consisting ofa) hydrogen and â€”OH, b) alkyl, alkenyl and alkynyl of up to 12 carbon atoms optionally interrupted by a member of the group consisting of oxygen, sulfur and nitrogen and unsubstituted or substituted with at least one member of the group consisting of halogen, â€”OH, â€”CN, â€”NO2 and c) alkoxy of 1 to 8 carbon atoms unsubstituted or substituted with at least one member of the group consisting of halogen, â€”OH, â€”CN, â€”NO2 and â€ƒRa and Rb are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing a second heteroatom selected from the group consisting of oxygen, sulfur and nitrogen; Rc and Rd are individually selected from the group consisting of hydrogen and alkyl of 1 to 12 carbon atoms optionally interrupted by a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally substituted by at least one member of the group consisting of halogen, â€”OH, â€”CN2 and â€”NO2 or taken together with the nitrogen form a heterocycle optionally containing a second heteroatom selected from the group consisting of oxygen, sulfur and nitrogen.