Patent ID: 6518045
Filing Date: 2003-02-11
Classification: A61K,C07K

Abstract:
A DNA having a nucleotide sequence coding for(1) a feline IL12 p40 polypeptide having the amino acid sequence as shown in SEQ ID NO:l, SEQ ID NO:1 with deletion, insertion or substitution at any one to several amino acid residues; SEQ ID NO:2; or SEQ ID NO:2 with deletion, insertion or substitution at any one to several amino acid residues; or a portion of the amino acid sequence as shown in SEQ ID NO:1; or any of foregoing polypeptides that is a recombinant polypeptide prepared by using a genetic recombination technique; or (2) a feline IL12 p35 polypeptide having the amino acid sequence as shown in SEQ ID NO:3; SEQ ID NO:3 with deletion, insertion or substitution at any one to several amino acid residues wherein the C-terminal amino acid sequence is Ala-Phe-Arg-Ile-Arg-Ala-Val-Thr-Ile-Asn-Arg-Met-Met-Ser-Tyr-Leu-Asn-Ser-Ser as shown in SEQ ID NO:10; SEQ ID NO:4; SEQ ID NO:4 with deletion, insertion or substitution at any one to several amino acid residues wherein the C-terminal amino acid sequence is Ala-Phe-Arg-Ile-Arg-Ala-Val-Thr-Ile-Asn-Arg-Met-Met-Ser-Tyr-Leu-Asn-Ser-Ser as shown in SEQ ID NO:10; or a portion of the amino acid sequence as shown in SEQ ID NO:3; or any of foregoing polypeptides that is a recombinant polypeptide prepared by using a genetic recombination technique; or (3) a protein of a homologous dimer of any of the polypeptides in the group (1); or (4) a protein of a homologous dimer of any of the polypeptides in the group (2); or (5) a protein of a heterologous dimer of any of the polypeptides in the group (1) with any of the polypeptides in the group (2).