Patent ID: 6818772
Filing Date: 2004-11-16
Classification: C07D

Abstract:
A compound of formula (I), or a therapeutically suitable salt or prodrug thereof, wherein R1, R2 and R3 are each independently a member selected from the group consisting of hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxy and RARBNâ€” wherein RA and RB are each independently a member selected from the group consisting of hydrogen and alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl and RCRDNcarbonyl, wherein RC and RD are each independently a member selected from the group consisting of hydrogen, alkyl and aryl; R4 is a member selected from the group consisting of hydrogen and alkyl; R5 is â€”(CH2)mâ€”Y-A-B; m is from 0-6; A is absent or is a member selected from the group consisting of alkoxyalkylene, alkylene and hydroxyalkylene; B is a member selected from the group consisting of aryl, arylC(O)â€”, arylS(O)2â€”, arylalkenyl, aryloxyalkyl, biaryl, biarylalkyl, cycloalkyl, heterocycle, heterocycleC(O)â€”, heterocycleS(O)2â€”, haloalkyl, RERFNâ€”, RERFNC(O)â€”, RGSâ€” and RGOâ€”, wherein the heterocycles may be substituted or unsubstituted and can be selected from the group consisting of azetidinyl, azepanyl, aziridinyl, diazepinyl, 1,3-dioxolanyl, dioxanyl, dithianyl, furyl, imidazolyl, imidazolinyl, imidazolidinyl, isothiazolyl, isothiazolinyl, isothiazolidinyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, morpholinyl, oxadiazolyl, oxadiazolinyl, oxadiazolidinyl, oxazolyl, oxazolinyl, oxazolidinyl, piperazinyl, piperidinyl, pyranyl, pyrazinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrazinyl, tetrazolyl, thiadiazolyl, thiadiazolinyl, thiadiazolidinyl, thiazolyl, thiazolinyl, thiazolidinyl, thienyl, thiomorpholinyl, 1,1-dioxidothiomorpholinyl (thiomorpholine sulfone), thiopyranyl, triazinyl, triazolyl, trithianyl, benzimidazolyl, benzodioxinyl, benzothiazolyl, benzothienyl, benzotriazolyl, benzoxazolyl, benzofuranyl, benzopyranyl, benzothiopyranyl, cinnolinyl, indazolyl, indolyl, 2,3-dihydroindolyl, indolizinyl, naphthyridinyl, isobenzofuranyl, isobenzothienyl, isoindolyl, isoquinolinyl, phthalazinyl, 4H-pyrido(1.2-a)pyrimidin-4-one, pyranopyridinyl, quinolizinyl, quinoxalinyl, acridinyl, carbazolyl, carbolinyl, dibenzo(b,d)furanyl, dibenzo(b,d)thienyl, naphtho(2,3-b)furan, naphtho(2.3-b)thienyl, phenazinyl, phenothiazinyl, phenoxazinyl, thianthrenyl, thioxanthenyl and xanthenyl; RE and RF are independently a member selected from the group consisting of hydrogen, alkyl, alkylC(O)â€”, aryl, arylalkyl, heterocycle, heterocyclealkyl, arylC(O)â€” and arylS(O)2â€”; RG is a member selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl and heterocycle; Y is a member selected from the group consisting of â€”C(O)â€”, â€”Sâ€”, â€”S(O)â€” and â€”S(O)2â€”, or is absent; R6 is a member selected from the group consisting of hydrogen, alkyl and arylcarboxyalkyl; and R7, R8, R9, and R10 are each independently a member selected from the group consisting of hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy and hydroxy or R7 and R8 taken together with the carbon atom that they are attached form oxo; with the following provisos P1-P5: P1 if Y is absent, m is 0 and if A is absent or is a member selected from the group consisting of alkoxyalkylene, alkylene and hydroxyalkylene, then B is a member selected from the group consisting of hydrogen, alkyl, arylC(O)â€”, arylS(O)2â€”, arylalkenyl, aryloxyalkyl, biarylalkyl, cycloalkyl, heterocycle, heterocycleC(O)â€”, heterocycleS(O)2â€”, haloalkyl, RERFNâ€”, RERFNC(O)â€”, RGSâ€” and RG(O)â€”; or P2 if Y is â€”C(O)â€”, m is 0 and A is absent, then B is a member selected from the group consisting of hydrogen, alkyl, arylalkenyl, aryloxyalkyl, cycloalkyl, heterocycle, haloalkyl, and RERFNC(O)â€”; or P3 if Y is â€”C(O)â€”, A is absent and B is aryl or heterocycle, then m is 1-6; or P4 if Y is â€”C(O)â€” and B is a member selected from the group consisting of arylC(O)â€”, arylS(O)2â€”, heterocycleC(O)â€”, heterocycleS(O)2â€”, then A is a member selected from the group consisting of alkoxyalkylene, alkylene and hydroxyalkylene; or P5 if Y is absent, m is 2, and A is absent, then B is not aryl.