Patent ID: 7329659
Filing Date: 2008-02-12
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): wherein Ar is phenyl, a six-membered heteroaromatic group containing one, two or three nitrogen atoms or a five-membered heteroaromatic group containing one, two, three or four heteroatoms chosen from oxygen, nitrogen and sulfur, at most one heteroatom being oxygen or sulfur, Ar being optionally substituted with one, two or three groups independently chosen from halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, amino, haloC 1-6 alkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, hydroxyC 1-6 alkyl, hydroxyC 2-6 alkenyl, hydroxyC 2-6 alkynyl, cyano, nitro, aminoC 1-6 alkyl, aminoC 2-6 alkenyl, aminoC 2-6 alkynyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, C 1-6 alkylthio, C 1-6 alkoxycarbonyl, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, NR 4 R 5 , CONR 4 R 5 or CO 2 NR 4 R 5 where each R 4 and R 5 is independently hydrogen or C 1-6 alkyl; R R R one X, Y and Z is N and the other two are CR or a pharmaceutically acceptable salt thereof.