Patent ID: 8946295
Filing Date: 2015-02-03
Classification: A61K,Y10S

Abstract:
1. A method for promoting a wound healing process in skin, mucosa, or cornea, comprising applying to a wound in a subject in the inflammation phase or the tissue forming phase of the wound healing process a pharmaceutical composition including a therapeutically effective amount of a histone deacetylase inhibitor or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the histone deacetylase inhibitor is selected from the group consisting of trichostatin A, trichostatin C, sodium butyrate, isovalerate, valerate, 4-phenylbutyrate, sodium phenylbutyrate, propionate, butyramide, isobutyramide, phenylacetate, 3-bromopropionate, valproic acid, valproate, and tributyrin, and wherein the wound is selected from the group consisting of ulcer resulting from a chemical injury, phototoxic reactions, ulcer from an infectious process, desquamation resulting from drug eruption, oral aphthae, contact and irritant stomatitis, and dental erosion.