Patent ID: 6218396
Filing Date: 2001-04-17
Classification: A61P,C07D

Abstract:
A compound of Formula I ##STR33##R.sub.1 is hydrogen, halogen, C.sub.1-5 alkoxy, hydroxyl, or C.sub.1-5 alkyl;R.sub.2 is C.sub.1-6 alkyl, substituted C.sub.1-6 alkylwhere the alkyl substituents are independently selected from one or more halogens,phenyl, substituted phenylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl,phenylC.sub.1-5 alkyl, or substituted phenylC.sub.1-5 alkylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, halogen, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl;R.sub.3 is hydrogen, hydroxy or C.sub.1-5 alkoxy if the dashed line is absent or is oxygen if the dashed line is present;R.sub.4 is hydrogen, C.sub.1-5 alkyl, phenylC.sub.1-5 alkyl or substituted phenylC.sub.1-5 alkylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, and trihaloC.sub.1-5 alkyl;R.sub.5 is C.sub.1-6 alkyl,substituted C.sub.1-6 alkylwhere the alkyl substituents are independently selected from one or more halogens,phenyl, substituted phenylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-8 alkyl, hydrogen, halogen, hydroxy, C.sub.1-8 alkyl, substituted C.sub.1-8 alkylwhere the alkyl substituents are independently selected from one or more halogens,C.sub.1-5 alkoxy, amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, C.sub.1-5 alkylcarbonyl, C.sub.1-5 alkoxycarbonyl, arylcarbonyl, nitrile, aminosulfonyl, C.sub.1-5 alkylsulfonyl, phenylsulfonyl, and substituted phenylsulfonylwhere the phenyl substituents are independently selected from one or more members the group consisting of C.sub.1-8 alkyl hydrogen, halogen, hydroxy and nitro;phenylC.sub.1-5 alkyl, substituted phenylC.sub.1-5 alkylwhere the phenyl substituents are independently selected from one or more members of the group consisting of C.sub.1-8 alkyl hydrogen, halogen, hydroxy, C.sub.1-8 alkyl, substituted C.sub.1-8 alkylwhere the alkyl substituents are independently selected from one or more halogens, C.sub.1-5 alkoxy, amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, C.sub.1-5 alkylcarbonyl, C.sub.1-5 alkoxycarbonyl, and nitro;X is oxygen, sulfur or NH;pharmaceutically acceptable salts thereof;and stereoisomers, racemic mixtures, as well as enantiomers thereof.