Patent ID: 8637436
Filing Date: 2014-01-28
Classification: C12Q,C40B,G01N,H01L

Abstract:
1. An integrated biosensor array, comprising, in order, a molecular recognition layer, an optical layer, and a sensor layer integrated in a sandwich configuration, wherein: (a) the molecular recognition layer comprises a plurality of different probes attached at different independently addressable locations, each of said independently addressable locations configured to receive an excitation photon flux directly from a single source located on a single side of said molecular recognition layer, wherein the molecular recognition layer transmits light to the optical layer; (b) the optical layer comprises an optical filter layer, wherein the optical layer transmits light from the molecular recognition layer to the sensor layer, whereby the transmitted light is filtered; and (c) the sensor layer comprises an array of optical sensors that detect the filtered light transmitted through the optical layer, said sensor layer comprising sensor elements fabricated using a CMOS fabrication process; wherein said molecular recognition layer, said optical layer and said sensor layer comprise an integrated structure in which said molecular layer is in contact with said optical layer and said optical layer is in contact with said sensor layer.