Patent ID: 7160855
Filing Date: 2007-01-09
Classification: A61K,A61P

Abstract:
1. A method for enhancing iron release from a ferritin comprising a ferritin pore and a site of iron release, said method comprising exposing the ferritin to a protein unfolding agent, a reducing agent, and an iron chelator, wherein the protein unfolding agent locally alters the ferritin structure at the ferritin pore or destabilizes the site of iron release, but does not promote ferritin disassembly, generalized unfolding, or global denaturation, wherein said method is performed in vitro, and wherein said protein unfolding agent is selected from the group consisting of a non-detergent chaotropic agent, the peptide consisting of SEQ ID NO: 1, the peptide consisting of SEQ ID NO: 2, the peptide consisting of SEQ ID NO: 3, the peptide consisting of SEQ ID NO: 4, the peptide consisting of SEQ ID NO: 5, the peptide consisting of SEQ ID NO: 6, and the peptide consisting of SEQ ID NO: 7.