Patent ID: 6114325
Filing Date: 2000-09-05
Classification: A61K,A61Q,C07C,C07D

Abstract:
A 1,2-di-substituted benzene-carboxamide derivative or a salt thereof expressed by the following Formula (I): ##STR89## wherein each of A and B is R.sup.1 or --(CH.sub.2)n-NR.sup.2 R.sup.3, wherein when A is R.sup.1, B is --(CH.sub.2)n-NR.sup.2 R.sup.3 and when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, B is R.sup.1 ;Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --;R.sup.1 is a hydrocarbon group of C.sub.10-30 ;R.sup.2 and R.sup.3 individually represent a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, or together represent a heterocyclic ring having 3-7 members;when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.2 may be a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, and R.sup.3 and R.sup.5 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms;when --Z--B is --OCONR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.2 may be a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, and R.sup.3 and R.sup.6 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms;R.sup.4 is selected from the group consisting of a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylamino group, a lower acylamino group, a lower alkoxy group and a lower acyloxy group;R.sup.5 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, or when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.5 and R.sup.3 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms;R.sup.6 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, or when --Z--B is --OCONR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.6 and R.sup.3 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms;l is an integer of 0-2; andn is an integer of 0-5.