Patent ID: 6982283
Filing Date: 2006-01-03
Classification: A61K,A61P

Abstract:
1. A method for treating drug-induced constipation comprising a step of administering an effective amount of 15-keto-prostaglandin compound to a subject suffering from drug-induced constipation or in need thereof of such treatment, wherein the 15-keto-prostaglandin compound is one represented by formula (I): wherein L,M and N are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl or oxo, wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have at least one double bond; A is —CH B is —CH R Ra is a saturated or unsaturated lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, oxo, hydroxy, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group; cyclo(lower)alkyl; cyclo(lower)alkyloxy; aryl; aryloxy; heterocyclic group; heterocyclic-oxy group.