Patent ID: 6622037
Filing Date: 2003-09-16
Classification: A61N

Abstract:
A transdermal administrating device comprising:an active electrode having a conductive electrode layer and a conductive drug layer applied on one surface of said conductive electrode layer, said conductive drug layer being capable of being placed in contact with skin; an inert electrode which is made of a conductive material, and which is capable of being placed in contact with skin and spaced from said active electrode; means for applying a variable bias voltage across said active electrode and said inert electrode; a set of first and second conductive electrode layers which are each made of a material having a different standard single electrode potential, and which are capable of being placed in contact with skin and spaced from each other; a controller connected to said first and said second conductive electrode layers in a non-dermocontact region for measuring an internal resistance of skin tissue between said first and said second electrode layers, said internal resistance being distinct from a contact resistance and a leak resistance between the first and second conductive electrode layers, and controlling an electric current passing through the skin tissue between said active electrode and said inert electrode based on said measured internal resistance; and dermocontact means for keeping said active electrode, said inert electrode, and said set of said first and said second electrodes in contact with skin.