Patent ID: 8014960
Filing Date: 2011-09-06
Classification: C12Q,G01N

Abstract:
1. A method supporting a diagnosis of a risk of cancer recurrence, comprising: measuring in a malignant tumor sample collected from a patient an expression level of a first cyclin dependent kinase (CDK), an activity value of the first CDK, an expression level of a second CDK and an activity value of the second CDK from a malignant tumor collected from a cancer patient to be examined; calculating a recurrence risk score by a first formula comprising wherein X represents a first CDK specific activity which is a ratio of the activity value of the first CDK to the expression level of the first CDK, wherein Y represents a specific activity ratio which is a ratio of a second CDK specific activity to the first CDK specific activity, wherein the second CDK specific activity is a ratio of the expression level of the second CDK to the activity value of the second CDK, wherein F(X) is a function of a correlation of X with a cancer recurrence rate, and wherein G(Y) is a function of a correlation of Y with the cancer recurrence rate.