Patent ID: 6784158
Filing Date: 2004-08-31
Classification: C07K

Abstract:
A method for preparing a compound of formula I or a salt thereof, comprising (a) treating a compound of formula II â€ƒor a salt thereof, wherein P is a protecting group, with an agent that forms an amide or ester or mixed carbonic anhydride or anhydride or acid halide, in a solvent selected from the group consisting of an organic solvent, a mixture of organic solvents, and a mixture of organic solvent(s) and water, to form a compound of formula III; â€ƒ(b) removing (i) any excess agent that forms the ester or mixed anhydride, (ii) any excess of the compound of formula II, and (iii) the solvent used in the reaction of step (a); (c) isolating the compound of formula III; (d) reacting, for a period of time and under conditions effective to produce a compound of formula V, the isolated compound of formula III, or a salt thereof, wherein R together with the carbonyl moiety is an amide or ester or mixed carbonic anhydride or anhydride or acid halide, with a compound of formula (IV) â€ƒin a solvent selected from an organic solvent, a mixture of organic solvents, and a mixture of organic solvent(s) and water, to produce the compound of formula (V) or a salt thereof, (e) deprotecting the compound of formula V in a conventional manner to obtain the compound of formula (I); (f) optionally converting the compound of formula (I) into a salt thereof; and (g) isolating the compound of formula (I) or a salt thereof.