Patent ID: 7033797
Filing Date: 2006-04-25
Classification: A61K,C07K,C12N

Abstract:
1. A method to distinguish between the presence of human papillomavirus 6 (HPV 6) and human papillomavirus 11 (HPV 11) antibodies in a sample suspected of containing either or both types of said antibodies comprising the steps of: a) contacting the sample with a modified recombinant human papillomavirus 6 (HPV6) L1 protein which comprises an HPV 11 conformational epitope; wherein the modified HPV 6 protein comprises a mutation at locations selected from the group consisting of: b) detecting binding between the antibodies present in the sample and the modified HPV6 protein; wherein binding to a heterologous HPV 11 conformational epitope indicates the presence of HPV 11 antibodies in the sample, and binding to a HPV 6 conformational epitope indicates the presence of HPV 6 antibodies in the sample.