Patent ID: 6835727
Filing Date: 2004-12-28
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinis selected from the group consisting of â€”(CH2)pâ€”NHâ€”S(O)2â€”R3, â€”(CH2)pâ€”NHâ€”COâ€”R4, â€”(CH2)pNR7R8, â€”CN, â€”NH(CH2)pR3, â€”C(O)NHR6 and â€”C(O)NR6; R2 is selected from the group consisting of hydrogen, alkyl, oxo, â€”(CH2)pâ€”NHâ€”S(O)2â€”R3, â€”(CH)2)pâ€”NHâ€”COâ€”R4, â€”C(O)2R6, â€”(CH2)pOR5, â€”OR6, â€”(CH2)pNR7R8, â€”CN, â€”NH(CH2)pR3, â€”(CH2)pR3, â€”R3, â€”C(O)NHR6 and â€”C(O)NR6; R3 is selected from the group consisting of aryl, arylalkyl, cycloalkyl, and heterocycloalkyl, wherein said aryl, arylalkyl and cycloalkyl groups are either unsubstituted or substituted with 1, 2 or 3 halogen atoms; R4 is selected from the group consisting of aryl, cycloalkyl, heterocycloalkyl, biaryl, CH(R10)â€”NHC(O)2R3, OR5, (CH2)pR9, (CH2)p(R9)q, wherein said aryl, cycloalkyl, heterocycloalkyl and biaryl, groups are either unsubstituted or substituted with 1, 2 or 3 halogen atoms; R5 is selected from the group consisting of alkyl, alkenyl, alkynyl, and (CH2)pR9; R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, and CH(R10)â€”NHC(O)2R3; R7 and R8 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, and â€”(CH2)pR3; or R7 and R8 are joined together to form a system selected from the group consisting of aryl and heterocycloalkyl; R9 is selected from the group consisting of aryl, cycloalkyl and heterocycloalkyl; R10 is selected from the group consisting of the side chains of the naturally occurring amino acids or unnaturally occurring amino acids; n is one or two; each p is independently an integer from zero to six; q is independently an integer from zero to four; or a pharmaceutically acceptable salt thereof.