Patent ID: 6534486
Filing Date: 2003-03-18
Classification: A61P,C07H,Y10S

Abstract:
A compound of formula (I): whereinR1 and R2 independently represent a group selected from: (i) C3-8cycloalkyl-; (ii) hydrogen; (iii) aryl2CHCH2â€”; (iv) C3-8cycloalkylC1-6alkyl-; (v) C1-8alkyl-; (vi) arylC1-6alkyl-; (vii) R4R5Nâ€”C1-6alkyl-; (viii) C1-6alkyl-CH(CH2OH)â€”; (ix) arylC1-5alkyl-CH(CH2OH)â€”; (x) arylC1-5alkyl-C(CH2OH)2â€”; (xi) C3-8cycloalkyl independently substituted by one or more â€”(CH2)pR6 groups; (xii) H2NC(&boxH;NH)NHC1-6alkyl-; (xiii) a group of formula â€ƒor such a group in which one methylene carbon atom adjacent to X, or both if such exist, is substituted by methyl; (xiv) â€”C1-6alkyl-OH; (xv) â€”C1-8haloalkyl; (xvi) a group of formula (xvii) aryl; and (xviii) â€”(CH2)fSO2NHg(C1-4alkyl-)2âˆ’g or â€”(CH2)fSO2NHg(arylC1-4alkyl-)2âˆ’g where f is 2 or 3 and g is an integer 0 to 2; Z5 represents N; Z1, Z2, Z3 and Z4 together with the carbon atom form a 5-membered heterocyclic aromatic ring; R4 and R5 independently represent hydrogen, C1-6alkyl, aryl, arylC1-6alkyl- or NR4R5 together may represent pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, azetidinyl, azepinyl, piperazinyl or Nâ€”C1-6alkylpiperazinyl; R6 represents OH, NH2, NHCOCH3 or halogen; R7 represents hydrogen, C1-6alkyl, â€”C1-6alkylaryl or â€”COC1-6alkyl; X represents NR7, O, S, SO or SO2; p represents 0 or 1; a and b independently represent an integer 0 to 4 provided that a+b is in the range 3 to 5; c, d and e independently represent an integer 0 to 3 provided that c+d+e is in the range 2 to 3; and salts and solvates thereof.