Patent ID: 6548486
Filing Date: 2003-04-15
Classification: A61P,C07D,C07H

Abstract:
A pharmaceutical composition for the treatment of viral infections comprising a monoester pharmaceutical composition of formula I:Nu-O-Fa wherein O is an oxygen, Nu is a nucleoside or nucleoside analogue, excluding adenosine, cytidine, guanosine, thymidine, 2'-deoxyadenosine, 2'-deoxycytidine, 2'-deoxyguanosine, and uridine, and Fa is an acyl group of a mono-unsaturated C18 or C20 &ohgr;-9 fatty acid, which fatty acid is esterified with a hydroxyl group in the 5â€²-position of the sugar moiety of the nucleoside or nucleoside analogue or with a hydroxyl group on the non-cyclic chain of the nucleoside analogue, wherein Nu-O-Fa is not 5â€²-O-oleyl-ara-cytidine or 2,2â€²-anhydro-5â€²-O-oleyl-ara-cytidine, and a pharmaceutically acceptable carrier or excipient.