Patent ID: 7994123
Filing Date: 2011-08-09
Classification: A61P,C07K,C12N

Abstract:
1. A fusion polypeptide comprising (a) a targeting polypeptide that comprises a human neuregulin heparin binding domain (N-HBD); and (b) fused directly C-terminally to the N-HBD, a peptide linker or spacer (S) that is the natural amino acid spacer of human neuregulin, the sequence of which is residues 131-195 of SEQ ID NO: 14, and (c) fused directly C-terminally to S, a targeted polypeptide that comprises human erbB4 receptor extracellular domain (B4-ECD) that is to be targeted and localized to the heparan sulfate-rich cell or tissue surface; wherein