Patent ID: 7318931
Filing Date: 2008-01-15
Classification: A61K,A61P

Abstract:
1. A composition, comprising: an organic solvent; a protein; a polyol selected from the group consisting of mannitol, trehalose and polyethylene glycol; and a metal cation; wherein the metal cation is divalent, the metal cation is zinc, the mass ratio of polyol to protein is from 100:1 to 1:100, the molar ratio of zinc to protein is from 1:1 to 10:1, the amount of polyol is from 1 to 10 weight % of the total mass of the polyol, zinc and protein, the polyol and zinc together provide a synergistic protection of the protein conformation and activity, and the polyol and zinc together provide superior protection against protein denaturing after exposure to an organic solvent selected from the group consisting of ethanol, NMP and benzyl alcohol.