Patent ID: 6011002
Filing Date: 2000-01-04
Classification: A61K,A61P,C07K,C12N

Abstract:
A circularly permuted ligand selected from the group consisting of interleukin 4 (IL-4), interleukin 2 (IL-2), granulocyte colony stimulating factor (G-CSF), and granulocyte/macrophage colony stimulating factor (GM-CSF) that is a modification of an original ligand having amino acid residues numbered sequentially 1 through J with an amino terminus at residue 1 and a carboxyl terminus at residue J, said modified ligand having the formula shown below:X.sup.1 --(L).sub.a --X.sup.2in which:a is 0 or 1:X.sup.1 is a peptide consisting of an amino acid sequence having the sequence of residues n+1 through J of said original ligand;X.sup.2 is a peptide consisting of an amino acid sequence having the sequence of residues 1 through n of said original ligand;n is an integer ranging from 1 to J-1; andL is a linker; and further wherein the amino acid terminus of the modified ligand is located in X.sup.1 and the carboxyl terminus of the modified ligand is located in X.sup.2.