Patent ID: 8912207
Filing Date: 2014-12-16
Classification: A01N,A61P,C07D

Abstract:
1. A compound of Formula I: wherein R 1 is: H; C C C phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R —(CHR —C(═O)R —C(═S)R —C(═O)OR —C(═S)OR —(CHR —C(═O)N(R —C(═S)N(R m is an integer from 1 to 3; R 2 is: H; or C alternatively R 1 and R 2 may be taken together to form: ═CR R 3 is independently C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 5 haloalkyl, C 2 -C 6 alkylcarbonyl, C 2 -C 6 alkylaminocarbonyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylaminocarbonyl, benzyl, phenyl, or 5- or 6-membered heteroaromatic ring, wherein each (hetero)aryl, phenyl, benzyl, or 5- or 6-membered heteroaromatic ring may be optionally substituted with 1 to 3 substituents independently selected from R 5 ; R 4 is independently halogen, C 1 -C 6 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 haloalkylthio, amino, C 1 -C 3 alkylamino, C 2 -C 6 alkoxycarbonyl, C 2 -C 6 alkylcarbonyl, or C 2 -C 6 alkylaminocarbonyl; R 5 is independently halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 haloalkylthio, amino, C 1 -C 6 alkylamino, C 2 -C 6 dialkylamino, C 2 -C 6 alkoxycarbonyl, or C 2 -C 6 alkylcarbonyl, nitro, or cyano; R 6 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl or benzyl wherein each of the phenyl or benzyl may be optionally substituted with 1 to 3 substituents independently selected from R 5 ; R 7 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxyalkyl, C 2 -C 6 alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or benzyl may be optionally substituted with 1 to 3 R 5 , or a 5- or 6-membered saturated or unsaturated ring containing 1 to 3 heteroatoms wherein each ring may be optionally substituted with 1 to 3 substituents independently selected from R 5 ; R 8 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxyalkyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1 to 3 R 5 , or a 5- or 6-membered saturated or unsaturated ring containing 1 to 3 heteroatoms wherein each ring may be optionally substituted with 1 to 3 substituents independently selected from R 5 ; R 9 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxyalkyl, C 2 -C 6 alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R 5 , or a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R 5 ; R 10 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxyalkyl, C 2 -C 6 alkylcarbonyl, benzyl, wherein the benzyl may be optionally substituted with 1-3 R 5 alternatively R 9 and R 10 may be taken together to form: a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R R 11 is H or C 1 -C 4 alkyl; R 12 is H, C 1 -C 4 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 , alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R 5 ; alternatively R 11 and R 12 may be taken together to form: a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R R 13 is H, C 1 -C 4 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 , alkylcarbonyl, phenyl or benzyl wherein each of the phenyl or the benzyl may be optionally substituted with 1-3 R 5 ; alternatively R 12 and R 13 may be taken together to form: a 5- or 6-membered saturated or unsaturated ring containing 1-3 heteroatoms wherein each ring may be optionally substituted with 1-3 R