Patent ID: 8188109
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. 13-Substituted 5,6-dihydrodibenzo[a,g]quinolizinium salt compounds (13-substituted protoberberines) of the general formula (I): wherein; R R X represents inorganic acid ion, organic acid ion or halide; and (a) n is an integer from 1 to 5 inclusive and G stands for —Y═(Ar) wherein any of said (C (b) n is 1 and G stands for —Z—Ar in which: Z is O(CH m is an integer from 0 to 3 inclusive; and Ar represents a 5-15 membered unsaturated or aromatic mono-, bi- or tricyclic carbocyclic or heterocyclic ring system, wherein any of said heterocyclic ring systems, for each occurrence, contains one o more heteroatoms selected from O, N, or S; and wherein any of said ring systems, for each occurrence, optionally contains from 1 to 4 substituents independently selected from halogen, cyano, nitro, hydroxy, amino, (di)(C or (c) n is 1 and G stands for —Z—Ar in which: trifluoromethyl, trichloromethyl, tribromomethyl, 3,3,3-trifluoroethyl, 3,3,3-trichloroethyl; hydroxy, methoxy, ethoxy, 3,3,3-trichloroethoxy, acetoxy, trifluoroacetoxy, trichloroacetoxy; amino, (di)methylamino, (di)ethylamino, acetamido, trifluoroacetamido; cyano, nitro, fluoro, chloro, iodo and bromo.