Patent ID: 6271349
Filing Date: 2001-08-07
Classification: A61K,C07K

Abstract:
A polypeptide selected from the group consisting of:a) a polypeptide having an amino acid sequence of amino acids 234 to 422 of SEQ ID NO:6, wherein said polypeptide is capable of binding TRAF 6;b) a polypeptide having an amino acid sequence of amino acids 422-616 of SEQ ID NO:6, wherein said polypeptide is capable of binding a TRAF selected from the group consisting of TRAF 1, TRAF 2, TRAF 3, TRAF 5 and TRAF 6;c) a polypeptide having an amino acid sequence of amino acids 339-422 of SEQ ID NO:6, wherein said polypeptide is capable of binding TRAF 6;d) a polypeptide having an amino acid sequence of amino acids 545-616 of SEQ ID NO:6, wherein said polypeptide is capable of binding a TRAF selected from the group consisting of TRAF 1, TRAF 2, TRAF 3, TRAF 5 and TRAF 6;e) a polypeptide having an amino acid sequence of amino acids 339-362 of SEQ ID NO:6, wherein said polypeptide is capable of binding TRAF 6;f) a polypeptide encoded by a DNA capable of hybridization to a DNA having a nucleotide sequence as set forth in SEQ ID NO:5 under stringent conditions, wherein said stringent conditions include hybridizing at 6.times.SSC at 63.degree. C. and washing in 3.times.SSC at 55.degree. C., and further wherein the polypeptide is capable of binding a TRAF selected from the group consisting of TRAF 1, TRAF 2,TRAF 3, TRAF 5 and TRAF 6;g) fragments of the polypeptides of (a), (c) or (e), wherein the fragments are capable of binding TRAF 6; andh) fragments of the polypeptides of (b), (d) or (f), wherein the fragments are capable of binding a TRAF selected from the group consisting of TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.