Patent ID: 7749959
Filing Date: 2010-07-06
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A method of treating a condition in a patient characterized by an increased serum HMGB 1 level as compared to a suitable control, and activation of an inflammatory cytokine cascade, comprising administering to the patient a therapeutically effective amount of a polypeptide, an antagonist of TNF and a pharmaceutically acceptable excipient, wherein said polypeptide does not contain an HMGB B box, and wherein said polypeptide inhibits release of a proinflammatory cytokine from a vertebrate cell and comprises an amino acid sequence selected from the group consisting of: i) an amino acid sequence having at least 80% sequence identity to SEQ ID NO:22; ii) an amino acid sequence having at least 80% sequence identity to SEQ ID NO:57; iii) an amino acid sequence having at least 80% sequence identity to SEQ ID NO:4; iv) the amino acid sequence of SEQ ID NO:57; v) a biologically active fragment of SEQ ID NO:57; vi) the amino acid sequence of SEQ ID NO:22; vii) a biologically active fragment of SEQ ID NO:22; and viii) the amino acid sequence of SEQ ID NO:4.