Patent ID: 6812250
Filing Date: 2004-11-02
Classification: A61P,C07C,C07D

Abstract:
A compound of the formula I, in whichA is phenyl or naphthyl, where the phenyl or naphthyl is unsubstituted or substituted 1, 2, or 3 times wherein each substituent is independently chosen from F, Cl, Br, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, Oâ€”(C2-C6)-alkenyl, Oâ€”(C2-C6)alkynyl, Sâ€”(C1-C6)-alkyl, Sâ€”(C2-C6)-alkenyl, Sâ€”(C2-C6)-alkynyl, SOâ€”(C1-C6)-alkyl, SO2â€”(C1-C6)-alkyl, SO2â€”NH2, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkylene, (C0-C6)-alkylene-COOH, (C0-C6)-alkylene-COOâ€”(C1-C7)-alkyl, (C0-C6)-alkylene-COOâ€”(C2-C7)-alkenyl, CONH2, CONHâ€”(C1-C6)-alkyl, CONâ€”[(C1-C6)-alkyl]2, CONHâ€”(C3-C6)-cycloalkyl, (C0-C6)-alkylene-NH2, (C0-C6)-alkylene-NHâ€”(C2-C6)-alkyl, (C0-C6)-alkylene-Nâ€”[(C1-C6)-alkyl]2, NHâ€”COâ€”(C1-C6)-alkyl, NHâ€”CO-phenyl, and NHâ€”SO2-phenyl, wherein the phenyl of NHâ€”CO-phenyl and and NHâ€”SO2-phenyl is unsubstituted or substituted 1 or 2 times wherein each substituent is independently chosen from F, Cl, CN, OH, (C1-C6)-alkyl, Oâ€”(C1-C6)-alkyl, CF3, OCF3, COOH, COOâ€”C1-C6)-alkyl and CONH2; R1, R2 are, independently of one another, H, (C1-C6)-alkyl, Oâ€”(C1-C6)-alkyl, COâ€”(C1-C6)-alkyl or COOâ€”(C1-C6)-alkyl; R3, R4, R5, R6 are, independently of one another, H, F, Cl, Br, OH, CF3, NO2, CN, OCF3, Oâ€”(C1-C6)-alkyl, Oâ€”(C2-C6)-alkynyl, Oâ€”(C2-C6)-alkynyl, Sâ€”(C1-C6)-alkyl, Sâ€”(C2-C6)-alkenyl, Sâ€”(C2-C6)-alkynyl, SOâ€”(C1-C6)-alkyl, SO2â€”(C1-C6)-alkyl, SO2â€”NH2, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C4)-alkylene, COOH, COOâ€”(C1-C6)-alkyl, COâ€”NH2, COâ€”NHâ€”(C1-C6)-alkyl, COâ€”Nâ€”[(C1-C6)-alkyl]2, COâ€”NHâ€”(C3-C7)-cycloalkyl, NH2, NHâ€”(C1-C6)-alkyl, Nâ€”[(C1-C6)-alkyl]2, NHâ€”COâ€”(C1-C6)-alkyl, NHâ€”CO-phenyl, or NHâ€”SO2-phenyl, wherein the phenyl of NHâ€”CO-phenyl and NHâ€”SO2-phenyl is unsubstituted or substituted 1 or 2 times wherein each substituent is independently chosen from F, Cl, CN, OH, (C1-C6)-alkyl, Oâ€”(C1-C6)-alkyl, CF3, OCF3, COOH, COOâ€”(C1-C6)-alkyl and COâ€”NH2; R7 is H, (C1-C6)-alkyl, or CO(C1-C6)-alkyl; R8 is H, (C1-C10)-alkyl, where the alkyl is unsubstituted or substituted 1, 2, or 3 times wherein each substituent is independently chosen from OH, CF3, CN, COOH, COOâ€”(C1-C6)-alkyl, COâ€”NH2, NH2, NHâ€”(C1-C6)-alkyl, Nâ€”[(C1-C6)-alkyl]2, NCOâ€”(C1-C6)-alkyl, NCOOâ€”(C1-C6)-alkyl, NCOOâ€”(C1-C6)-alkenyl, NCOOâ€”(C1-C6)-alkenyl and NCOOâ€”(C1-C4)-alkylene-(C6-C10)-aryl; or (CH2)m-aryl, where m ranges from 0-6, and aryl is phenyl, O-phenyl, CO-phenyl, tetrahydronaphthyl or naphthyl, where the aryl is unsubstituted or substituted by at least one R9; R9 is F, Cl, Br; OH, NO2, CF3, OCF3, (C1-C6)-alkyl, (C1-C6)-alkyl-OH, Oâ€”(C1-C6)-alkyl, Sâ€”(C1-C6)-alkyl, (C1-C4)-alkylphenyl, COOH, or COOâ€”(C1-C6)-alkyl; or a physiologically tolerable salt thereof, in any stereoisomeric form[, or a mixture of any such compounds in any ratio].