Patent ID: 8932601
Filing Date: 2015-01-13
Classification: A61P,C07K

Abstract:
1. A hybrid protein consisting of: a functional unit of a complement regulatory protein, the functional unit consisting of Complement Control Protein repeats (CCPs) 2, 3 and 4 of human DAF or CCPs 1, 2, 3, and 4 of human DAF, the functional unit having decay accelerating activity against classical pathway and alternative pathway convertase, a targeting moiety that enhances binding of the hybrid protein to an animal tissue, wherein the targeting moiety is a lipid tail that targets a cell membrane bilayer, and a polypeptide spacer sequence is attached to and separates the functional unit and the targeting moiety, wherein the spacer sequence does not exhibit complement regulating properties and comprises at least 200 consecutive amino acids of SEQ ID NO: 3 CCPs 4-7 of CR1 (residues 239 to 496 of SEQ ID NO: 3) or CCPs 11-14 of CR1 (residues 689 to 874 through of SEQ ID NO: 3).