Patent ID: 8642091
Filing Date: 2014-02-04
Classification: A61K,A61P,B01D,B01J

Abstract:
1. A method for producing a suspension or dispersion of solid composite lipid/drug nanoparticles in an aqueous liquid comprising: dissolving a lipid that is a solid phase material at 1 atmosphere pressure and 15° C. temperature and a drug in a suitable organic solvent to form a solution, wherein the weight ratio of the drug to the lipid in the solution is from about 5:95 to about 40:60 and wherein the drug/lipid loading in the solution is from 1% to about 50% by weight of the organic solvent; emulsifying the solution in the aqueous liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the aqueous liquid; and contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing the lipid and the drug to precipitate from the micelles into the aqueous liquid in the form of solid composite lipid/drug nanoparticles that are suspended or dispersed in the aqueous liquid.