Patent ID: 7332608
Filing Date: 2008-02-19
Classification: A61P,C07C,C07D

Abstract:
1. A process for preparing a compound of formula I, in which: A is —C O is oxygen; D is a bond or oxygen; E is —C R(8) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or C R(9) is hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms; R(10) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, aryl or heteroaryl, R(11) is cycloalkyl having 3, 4, 5 or 6 carbon atoms, phenyl, naphthyl, thienyl, furyl, pyridyl, pyrazinyl, pyridazinyl, or pyrimidyl, R(12) alkyl having 1, 2, 3 or 4 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, aryl or heteroaryl, R(13) is C p H 2p —R′(14); R′(14) is cycloakyl having 3, 4, 5 or 6 carbon atoms tetrahydrofuranyl, tetrahydropyranyl, aryl or heteroaryl, R(15) is cycoalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms; R(2) is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R(3) is alkyl having 3, 4, 5, 6 or 7 carbon atoms, cycloalkyl having 3, 4, 5 and 6 carbon atoms, phenyl or naphthyl, where phenyl or naphthyl are unsubstituted of substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF R(4), R(5), R(6) and R(7) are, independently of one another, selected from the group consisting of hydrogen, F, Cl, Br, I, CF or a pharmaceutically acceptable salt thereof, which comprises, a) reacting an aminocarboxylic acid of formula II with a sulfonyl chloride of formula R(3)-SO 2 —Cl or a sulfonic acid anhydride in the presence of a base, and b) reacting the resulting sulfonylaminocarboxylic acid of formula III with an amine of formula HR(1) to the compound of formula I, where, in the compounds of the formulae II and III, R1 to R7 are each as defined in formula I.