Patent ID: 7001913
Filing Date: 2006-02-21
Classification: A61P,C07D

Abstract:
1. A compound of formula (I) or a pharmaceutically acceptable salt or N-oxide thereof: wherein: one of Z R amino optionally substituted by one or two (C carboxy; (C 1-6 )alkoxycarbonyl; aminocarbonyl, wherein the amino group is optionally substituted by hydroxy, (C 1-6 )alkyl, hydroxy(C 1-6 )alkyl, aminocarbonyl(C 1-6 )alkyl, (C 2-6 )alkenyl, (C 1-6 )alkylsulphonyl, trifluoromethylsulphonyl, (C 1-6 )alkenylsulphonyl, (C 1-6 )alkoxycarbonyl, (C 1-6 )alkylcarbonyl, (C 2-6 )alkenyloxycarbonyl or (C 2-6 )alkenylcarbonyl and optionally further substituted by (C 1-6 )alkyl, hydroxy(C 1-6 )alkyl, aminocarbonyl(C 1-6 )alkyl or (C 2-6 )alkenyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R 10 ; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R 10 ; or 5-oxo-1,2,4-oxadiazol-3-yl; or (C in addition when R when R (C (C R n is 0, 1 or 2; A is NR wherein: each of R or R or R provided that: when A is NR when A is CO, B is not CO, O or SO when n is 0 and A is NR when A is CR when n is 0, B is not NR when A–B is CR R R