Patent ID: 7872052
Filing Date: 2011-01-18
Classification: A61K,A61P

Abstract:
1. A method for treatment of a skin disease in a mammal, wherein the skin disease is selected from the group consisting of atopic dermatitis, contact dermatitis, eczema, psoriasis, acne, epidermal hyperkeratosis, acanthosis, epidermal inflammation, dermal inflammation and pruritus, and wherein the mammal has symptoms of the skin disease and the treatment reduces the symptoms wherein the method comprises topically administering to the mammal an effective amount of at least one compound with formula I or II: wherein X is O or S; Y is independently O, S, NH or N if the nitrogen atom is bonded to an adjacent carbon atom via a double bond; Z is independently O, NH or N if the nitrogen atom is bonded to an adjacent carbon atom via a double bond; W, Q, V, and T are independently CH, CH ring A, ring B, ring C and ring D may be aromatic, saturated or partly saturated; R or R R R or a pharmaceutical acceptable salt thereof.