Patent ID: 6403652
Filing Date: 2002-06-11
Classification: A61K,A61P

Abstract:
A composition comprising:(a) at least about 5 wt. % of a surfactant or mixture thereof; and (b) an antibacterial effective amount of a compound of at least minimum effectiveness against methicillin drug resistant bacteria, said compound of the formula: wherein R1 is selected from the group consisting of branched alkyl of four to about twenty carbon atoms, cycloalkyl of from four to about eight carbon atoms, mono cycloalkyl substituted alkyl of from four to about twelve carbon atoms where cycloalkyl is about four to about eight carbon atoms, and mono to tetra alkyl substituted cycloalkyl of from four to about eight carbon atoms wherein alkyl is one to about four carbon atoms; R2 is at the 4 or 5 position and is selected from the group consisting of branched alkyl of four to about twenty carbon atoms, cycloalkyl of from four to about eight carbon atoms, mono cycloalkyl substituted alkyl of from four to about twelve carbon atoms where cycloalkyl is about four to about eight carbon atoms, and mono to tetra alkyl substituted cycloalkyl of from four to about eight carbon atoms wherein alkyl is one to about four carbon atoms; wherein n is 0 or 1 and R4 is selected from the group consisting of hydrogen, alkyl of one to twenty carbon atoms, cycloalkyl of four to about eight carbon atoms, and mono to tetra alkyl substituted cycloalkyl of from four to about eight carbon atoms wherein alkyl is one to about four carbon atoms; R3 is selected from the group consisting of hydrogen and alkyl of one to three carbon atoms with the proviso that when R2 is at the 4 position then R3 is at the 5 position and when R2 is at the 5 position then R3 is at the 4 position; and pharmaceutically acceptable salts thereof.