Patent ID: 6579967
Filing Date: 2003-06-17
Classification: A61P,C07K,Y10S

Abstract:
A cyclic somatostatin(SRIF) analog peptide which selectively binds the SRIF receptor SSTR3 in contrast to other SRIF receptors, wherein said peptide has the amino acid sequence (cyclo 3-14)Xaa1-Xaa2-Xaa3-Phe-Xaa7-D-Xaa8-Lys-Thr-Xaa11-Cys wherein Xaa1 is des-Xaa, D-Ala, Ala, Cbm, L-Hor or an acyl group having up to 20 carbon atoms; Xaa2 is Tyr, D-Tyr, Gly or des-Xaa; Xaa3 is Cys or D-Cys; Xaa7 is an amino acid selected from the group consisting of (A)Phe, Tyr or N&bgr;MeAgl(Bz) wherein A is H, Cl, F, Br, NO3, Me, OMe or NH(Q) where Q is H, Cbm or L-Hor; D-Xaa8 is an amino acid selected from the group consisting of D-Nal and N&bgr;MeD-Agl(Np); and Xaa11 is Phe, Aph(X) or Tyr with X being H, Ac or Cbm; provided that either Xaa7 is N&bgr;MeAgl(Bz) or D-Xaa8 is N&bgr;MeD-Agl(Np).