Patent ID: 6803388
Filing Date: 2004-10-12
Classification: A61K,A61P,C07B,C07C,C07D

Abstract:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein;n is 1 or 2; R1 is haloalkyl or haloalkoxyalkyl, with the proviso that R1 is selected to have the highest Cahn-Ingold-Prelog stereochemical system ranking of three groups bonded to the hydroxy-substituted carbon to which R1 and R2 are attached in radical Ia: â€ƒwhich radical Ia is a fragment of the Formula I and with the further proviso that said haloalkyl has two or more halo substituents; R2 is hydrido; R3 is hydrido; R4, R8, R9, and R13 are independently hydrido or halo; R5, R6, R7, R10, R11, and R12 are independently selected from the group consisting of hydrido, perhaloaryloxy, alkanoylalkyl, alkanoylakoxy, alkanoyloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-alkylcarboxamido, N-haloalkylcarboxamido, N-cycloalkylcarboxamido, N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aroylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, hterocyclyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, cycloalkoxy, cycloalkylalkoxy, hydroxy, amino, thio, nitro, alkylamino, alkylthio, arylamino, aralkylamino, arylthio, arylthioalkyl, alkylsulfonyl, alkylsulfonamido, monoarylamidosulfonyl, arylsulfonyl, heteroarylthio, heteroarylsulfonyl, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, hteroaroyl, aralkanoyl, hteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkylenedioy, haloalylenedioxy, cycloalkyl , cycloalkylalkanoyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl, hydroxyhaloalkoxy, hydroxyalkyl, aryl, alryloxy, aralkoxy, saturated heterocyclcyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, heteroaralkyl, arylakenyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboxamido, carboxamidoalkyl, and cyano; with the proviso that at least one of R4, R5, R6, R7, and R8 is not hydrido and with the further proviso that at least one of R9, R10, R11, R12, arid R13 is not hydrido.