Patent ID: 6346534
Filing Date: 2002-02-12
Classification: C07D

Abstract:
A compound having the following structure: and stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein:m is an integer from 1 to 6; R1 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, aryl(CR3cR3d)n, substituted aryl(CR3cR3d)n, heteroaryl(CR3cR3d)n or substituted heteroaryl(CR3cR3d)n; R2 is hydrogen, alkyl or substituted alkyl; or R1 and R2 taken together with the nitrogen atom to which they are attached form a heterocycle ring or a substituted heterocycle ring; R3a, R3b, R3c and R3d are the same or different and independently at each occurrence hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, thioalkyl, amino, alkylamino, dialkylamino, cyano, halogen, â€”C(&boxH;O)OR7 or â€”C(&boxH;O)NR7R8; or R3a and R3b, or R3c and R3d, taken together with the carbon atom to which they are attached form a carbocyclic ring or substituted carbocyclic ring; or R3a and R1, taken together with the carbon atom and nitrogen atom, respectively, to which they are attached form a heterocyclic ring or substituted heterocyclic ring; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; R5 is hydrogen, halogen, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, thioalkyl or mono- or di-alkylamine; R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, substituted heterocycle, â€”OR7, â€”SR7, â€”SOR7, â€”SO2R7, â€”OSO2R7, â€”SO2OR7, â€”SO2NR7R8, â€”NR9SO2R7, â€”C(&boxH;O)R7, â€”C(&boxH;O)OR7, â€”OC(&boxH;O)R7, â€”NR7R8, â€”C(&boxH;O)NR7R8, â€”OC(&boxH;O)NR7R8, â€”NR9C(&boxH;O)R7, â€”NR9C(&boxH;O)NR7R8, â€”NR8C(&boxH;O)OR7 or â€”C(OH)R7R8; R7, R8 and R9 are the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; or R7 and R8 taken together with the nitrogen atom to which they are attached form a heterocycle ring or a substituted heterocycle ring; n is an integer from 1 to 6; and B and Ar are as follows: B is nitrogen or CR10 when Ar is heteroaryl or substituted heteroaryl and R10 is hydrogen; or B is CR10 when Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl and R10 is halogen, cyano, nitro, amino, mono- or di-alkylamino or alkyl.