Patent ID: 6489297
Filing Date: 2002-12-03
Classification: A61K,A61P,C07K,Y10S

Abstract:
A vasoactive intestinal peptide analog of the formula (I)His-Ser-Asp-R1-Val-R2-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln R3Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 wherein R1 is Aib, Deg or Ac5c, R2 is Phe or 4-Cl-D-Phe, R3 is Met, Leu Dpg or a hydrolyzable carboxy protecting group; or pharmaceutically acceptable salts thereof wherein Aib is &agr;-amino-isobutyric acid, Deg is diethylglycine, Ac5c is 1-aminocyclopentane carboxylic acid and Dpg is di-n-propylglycine.