Patent ID: 8003658
Filing Date: 2011-08-23
Classification: A61P,C07D

Abstract:
1. A quinazoline derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein, R R R Y is —(CR 11 R 12 )—, phenyl or a 5-membered heteroaryl having 1 sulfur atom, R 11 and R 12 being each independently hydrogen, halogen, hydroxy, carboyC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, phenyl, or optionally fused to each other to form a 3 membered non-aromatic ring, or R 11 or R 12 may be fused to R 2 to form together with the carbon and nitrogen they are attached to a 4 to 8-membered non-aromatic ring, optionally comprising additional heteroatom S; R R R n is an integer in the range of 1 to 4; p is 0 or 1; X is a halogen, nitro, cyano, trifluoromethyl, C