Patent ID: 9216963
Filing Date: 2015-12-22
Classification: A61K,A61P,C07D

Abstract:
1. A method of optically diagnosing renal function in a patient, comprising the steps of: administering a pyrazine derivative or a pharmaceutically-acceptable salt thereof to a patient; exposing the administered pyrazine derivative to visible and/or near infrared light; detecting spectral energy emanating from the administered pyrazine derivative; and determining clearance of the pyrazine derivative from the body of the patient; wherein the administered pyrazine derivative absorbs and emanates spectral energy in the visible and/or near infrared spectrum; wherein the pyrazine derivative is of the following Formula 1, and wherein: X is —Ar—Y, —C(R Ar is phenyl, biphenyl, pyridyl, pyridazyl, pyrimidinyl, pyrazinyl, pyrrolyl, furanyl, thiopheneyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazinyl, triazolyl or thiadiazolyl; with the proviso that if Ar is phenyl, pyrrolyl, or thiopheneyl, then at least one of R each Y is independently hydrogen, C each of, R (AA) (PS) each of R each of R each of a, b, and d is independently an integer from 1 to 10; and c is an integer from 1 to 100.