Patent ID: 9061024
Filing Date: 2015-06-23
Classification: A61K

Abstract:
1. A method of providing an opioid agonist to a mammalian subject in a manner that inhibits peripheral effects of the opioid agonist, without blocking substantial central effects, the method comprising: orally administering to the subject at least one unit dosage of an analgesic composition, formulated for oral administration, the unit dosage including: (a) the opioid agonist in an amount sufficient to confer analgesia in the subject; (b) a non-aversive neutral opioid antagonist in an amount sufficient to substantially inhibit peripheral effects and insufficient to block substantial central effects of the agonist in the subject, the opioid antagonist selected to have an access to a central nervous system of the subject that is weak compared to access by the opioid agonist; wherein the amounts of the neutral opioid antagonist and the opioid agonist are selected so that a weight/weight (w/w) ratio of (1) an amount of 6β-naltrexol equivalent to the amount of neutral opioid antagonist divided by (2) an amount of morphine equivalent to the opioid agonist is at least 0.15; and (c) a pharmaceutically acceptable carrier.