Patent ID: 6297376
Filing Date: 2001-10-02
Classification: A61P,C07D

Abstract:
A process for the preparation of a compound of formula (I) ##STR9##wherein R.sub.2 and R.sub.3 are independently selected from the group consisting of:(1) hydrogen,(2) C.sub.1-6 alkyl.(3) C.sub.2-6 alkenyl, and(4) phenyl; R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of:(1) hydrogen,(2) C.sub.1-6 alkyl,(3) fluoro,(4) chloro,(5) bromo,(6) iodo, and(7) -CF.sub.3 ; R.sup.11, R.sup.12 and R.sup.13 are independently selected from the group consisting of:(1) hydrogen,(2) C.sub.1-6 alkyl,(3) fluoro,(4) chloro(5) bromo,(6) iodo, and(7) -CF.sub.3 ; and Z is C.sub.1-4 alkyl,which comprises:(i) reacting a compound of formula (II) ##STR10##or a salt thereof, wherein R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13 and Z are as previously defined, with compound of formula (III) ##STR11##wherein LG is a leaving group selected from halogen or an alkyl- or arylsulfonate group, in an organic solvent and in the presence of a base; and(ii) collecting the resultant crystalline compound of formula (I).