Patent ID: 7504401
Filing Date: 2009-03-17
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically-acceptable salt thereof, wherein: A A A R R n is 1, and L is —C(O)— X is Ar, HetAr or BiHetAr, wherein Ar is an aryl group having 6-10 carbons in the ring portion, HetAr is a 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, or HetAr is a 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, and BiHetAr is a heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur; wherein Ar, HetAr and BiHetAr are each optionally substituted with one or two substituents independently selected from the group consisting of halo, hydroxy, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, nitro, cyano, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, amino, monoalkylamino, dialkylamino, formylamino, alkylcarbonylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, sulfonyl-amino, alkylsulfonylamino, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, morpholinyl and formyloxyalkoxyalkyl; provided that: (1) when A at least one of R (2) when each of R X is HetAr or BiHetAr.