Patent ID: 6747034
Filing Date: 2004-06-08
Classification: A61P,C07D

Abstract:
A compound having the following structure:including stereoisomers and pharmaceutically acceptable salts thereof, wherein:R1 is â€”CH(R4)(R5); R2 is C1-6alkyl; R3 is hydrogen or C1-6alkyl; R4 is hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl, or C1-6alkyloxyC1-6alkyl, and R5 is C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar1CH2, C3-6alkenyl, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl, â€”CH2Obenzyl, or a radical of the formula â€”(C1-6alkanediyl))â€”Oâ€”COâ€”Ar1, or R4 and R5 taken together with the carbon atom to which they are bonded form a C5-8cycloalkyl optionally substituted with one or more substituents independently selected from C1-6alkyl; Ar is phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, trifluoromethyl, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino, and mono- or di(C1-6alkyl)amino; or an aromatic C3-12heterocycle optionally substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino, mono- or di(C1-6alkyl)amino, and piperidinyl; and Ar1is phenyl, pyridinyl, or phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C1-6alkyl, C1-6alkyloxy, di(C1-6alkyl)aminoC1-6alkyl, trifluoromethyl and C1-6alkyl substituted with morpholinyl.