Patent ID: 6329362
Filing Date: 2001-12-11
Classification: A61K,A61P,C07C,C07D,C07K,Y10S

Abstract:
A compound of formula (1): ##STR13##whereinR.sup.1, R.sup.2 and R.sup.3 which may be the same or different is each an atom or group --L.sup.2 (Alk.sup.2).sub.t L.sup.3 (R.sup.8).sub.u in which L.sup.2 and L.sup.3 which may be the same or different is each, a covalent bond or a linker atom or group, t is zero or the integer 1, u is zero or an integer 1, 2 or 3, Alk.sup.2 is an aliphatic or heteroaliphatic chain and R.sup.8 is a hydrogen or halogen atom or a group selected from alkyl, --OR.sup.9 (where R.sup.9 is a hydrogen atom or an optionally substituted alkyl group), --SR.sup.9 --NR.sup.9 R.sup.10 (where R.sup.10 is as just defined for R.sup.9 and may be the same or different), --NO.sub.2, --CN, --CO.sub.2 R.sup.9, --OCO.sub.2 R.sup.9, --CONR.sup.9 R.sup.10, --OCONR.sup.9 R.sup.10, --CSNR.sup.9 R.sup.10, --COR.sup.9, --OCOR.sup.9, --N(R.sup.9)COR.sup.10, --N(R.sup.9)CSR.sup.10, --SO.sub.2 N(R.sup.9)(R.sup.10), --N(R.sup.9)SO.sub.2 R.sup.10, --N(R.sup.9)CON(R.sup.10)(R.sup.11) (where R.sup.11 is a hydrogen atom or an optionally substituted alkyl group), --N(R.sup.9)CSN(R.sup.10)(R.sup.11) or --N(R.sup.9)SO.sub.2 N(R.sup.10)(R.sup.11) provided that when one of R.sup.1, R.sup.2 or R.sup.3 is at the 3-position of the phenyl ring it is an atom or group --L.sup.2 (Alk.sup.2).sub.t L.sup.3 (R.sup.8).sub.u, in which R.sup.8 is as just defined other than a --N(R.sup.9)CON(R.sup.10)(R.sup.11) or --N(R.sup.9)CSN(R.sup.10)(R.sup.11) group;Alk.sup.1 is an optionally substituted aliphatic or heteroaliphatic chain;L.sup.1 is a covalent bond or a linker atom or group;R.sup.4 and R.sup.5, which may be the same or different, is each a hydrogen or halogen atom or an alkyl, alkoxy, hydroxy or nitro group;R.sup.6 is an atom or group --L.sup.2 (Alk.sup.2).sub.t L.sup.3 R.sup.12 in which L.sup.2, L.sup.3, Alk.sup.2 and t are as previously defined and R.sup.12 is a hydrogen or halogen atom or an --OR.sup.9,--NR.sup.9 R.sup.10, --NO.sub.2, --CN, --CO.sub.2 R.sup.9, --CONR.sup.9 R.sup.10, --COR.sup.9, --N(R.sup.9)COR.sup.10, --N(R.sup.9)CSR.sup.10, --SO.sub.2 N(R.sup.9)(R.sup.10), --N(R.sup.9)SO.sub.2 R.sup.9, --N(R.sup.9)CON(R.sup.10)(R.sup.11), --N(R.sup.9)CSN(R.sup.10)(R.sup.11), --N(R.sup.9)SO.sub.2 N(R.sup.10)(R.sup.11), or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group;R.sup.7 is an --L.sup.2 R.sup.12a or --L.sup.2 Alk.sup.2 R.sup.12a group in which R.sup.12a is an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group;r is zero or the integer 1;R is a carboxylic acid (--CO.sub.2 H) or a derivative thereof;and the salts, solvates, hydrates and N-oxides thereof, for use in modulating cell adhesion.