Patent ID: 7817840
Filing Date: 2010-10-19
Classification: G01N,G06K,G06T

Abstract:
1. A method of assessing the hepatotoxicity of a stimulus, the method comprising: (a) exposing a hepatocyte culture to the stimulus; (b) imaging the hepatocytes with an optical image acquisition system configured to capture digital images; (c) analyzing a digital image of the hepatocytes to extract features characterizing the hepatocytes by executing instructions on a computer system; (d) classifying the stimulus by quantitatively evaluating the extracted features to identify one or more hepatotoxic pathologies resulting from the stimulus by executing instructions on a computer system, wherein hepatotoxic pathology classifications include two or more of the following: necrosis, cholestasis, steatosis, fibrosis, apoptosis, and cirrhosis; and (e) displaying the one or more hepatotoxic pathology classifications on a display.