Patent ID: 6096904
Filing Date: 2000-08-01
Classification: A61P,C07C,C07D,C07F,Y02P

Abstract:
A process for producing a diene having formula: ##STR71## wherein: R.sub.1, R.sub.2, R.sub.7, R.sub.8, R.sub.11, and R.sub.12 are, independently, C.sub.1 -C.sub.10 alkyl;R.sub.3, R.sub.6 and R.sub.16 are, independently, selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl;R.sub.4, R.sub.9, R.sub.14 and R.sub.15 are, independently, acid labile hydroxyl protecting groups; andR.sub.25 is an acid stable hydroxyl protecting group;comprising contacting a phosphonium salt having formula: ##STR72## wherein R.sub.18 is C.sub.1 -C.sub.6 aryl and X is a halogen with a base and a compound having formula: ##STR73## for a time and under conditions effective to form said diene.