Patent ID: 7943743
Filing Date: 2011-05-17
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. An isolated human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody or antigen-binding portion thereof cross-competes for binding to PD-L1 with a reference antibody or reference antigen-binding portion thereof comprising: (a) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:1 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:11; (b) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:2 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:12; (c) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:3 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:13; (d) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:4 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:14; (e) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:5 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:15; (f) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:6 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:16; (g) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:7 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:17; (h) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:8 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:18; (i) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:9 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:19; or (j) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:10 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO:20.