Patent ID: 6462093
Filing Date: 2002-10-08
Classification: A61K

Abstract:
A method for producing a solid dispersion of a sparingly water-soluble medical substance comprisingheat treating a sparingly water-soluble medical substance, an amorphous state-inducing agent selected from the group consisting of amino acid or its salt, Aspartame, erythorbic acid or its salt, ascorbic acid or its salt, stearic acid ester, aminoethylsulfonic acid, inositol, ethylurea, citric acid or its salt, glycyrrhizinic acid or its salt, gluconic acid or its salt, creatinine, salicylic acid or its salt, tartaric acid or its salt, succinic acid or its salt, calcium acetate, sodium saccharin, aluminum hydroxide, sorbic acid or its salt, dehydroacetic acid or its salt, sodium thiomalate, nicotinic acid amide, urea, fumaric acid or its salt, macrogols, maltose, maltol, maleic acid, mannitol, meglumine, sodium desoxycholate and phosphatidylcholine, and an amorphous state-stabilizing agent selected from the group consisting of cellulose derivatives, polyvinyl pyrrolidone, cross-linked polyvinyl pyrrolidone, polyvinyl alcohol, polyvinyl acetate, vinyl alcohol/vinyl acetate copolymer, ethylene/vinyl acetate copolymer, polyethylene oxide derivatives, sodium polystyrene sulfonate, gelatin, soluble starch, pullulan, dextran, gum arabic, chondroitin sulfuric acid or its sodium salt, hyaluronic acid, pectin, chitin, chitosan, &agr;, &bgr;, &ggr;-cyclodextrin, alginic acid derivatives, acryl resins, polyvinyl acetal diethylaminoacetate, silicon dioxide and aluminium hydroxide, wherein the method excludes a solvent method and a mechanochemical method.