Patent ID: 6270957
Filing Date: 2001-08-07
Classification: A61K,C07K

Abstract:
Non-immunosupressive cyclosporins comprising a cyclic undecapeptide of Formula I: ##STR55##wherein V is a MeLeu(3-OH), MeLeu, MeSer, MeSer-PG, MeThr, or MeThr-PG residue;W is a (D)-N-methyl-amino acid or an N-methylglycyl residue;X and X' are independently an N-methyl-leucinyl or an N-methylalanyl residue;Y is a lysyl, homo-lysyl, ornithinyl, lysyl-PG, homo-lysyl-PG, or ornithinyl-PG residue;wherein each PG is, independently, a side-chain protecting group; andZ is absent or is an HIV protease inhibitor moiety conjugated to Y via a side-chain on Y and selected from the group consisting of ##STR56##wherein R is Ac-Ser-Leu-Asn; and salts thereof.