Patent ID: 6485941
Filing Date: 2002-11-26
Classification: A61K,C07D,C07H

Abstract:
A method for inhibiting the carboxyltransferase activity of acetyl-CoA carboxylase, comprising reacting the acetyl-CoA carboxylase with a composition comprising Compound 1:phenylmethyl 5-(1-{[(2-{[N-(2,4-dihydroxy-3,3-dimethylbutanyl)-5-(6-aminooctahydro-9H-purin-9-yl)-4-(hydroxy-2-[(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate-&bgr;-alanyl]amino}ethyl)thio]acetyl}-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate; wherein the amount of the Compound 1 is sufficient to reduce the activity of carboxyltransferase by a statistically significant degree.