Patent ID: 6326391
Filing Date: 2001-12-04
Classification: A61K,A61P,C07D,Y02A

Abstract:
A method for enhancing the antibacterial action of fluorquinolones comprising contacting a bacterium with an indole inhibitor of NorA, said indole having the formula: ##STR39##wherein R.sub.1 is phenyl, 2-napthyl, o-anisole, R.sub.2 is H or CH.sub.3, R.sub.1 and R.sub.2 are two napthyl groups fused to the indole ring, R.sub.3 is H, R.sub.4 is NO.sub.2, SO.sub.3 H, NH.sub.2, CF.sub.3 or CCl.sub.3, R.sub.5 is H, and R.sub.6 is H.