Patent ID: 7790679
Filing Date: 2010-09-07
Classification: A61K,C07K

Abstract:
1. A stable aqueous sterile formulation comprising (a) Darbepoetin (SEQ. ID NO.: 1) or erythropoietin (SEQ. ID NO.: 2) or an erythropoietin analog with at least 90% homology to SEQ. ID NO.: 2 at a concentration of up to about 15 mg/ml, (b) a destabilizing concentration of benzyl alcohol at a concentration of at least about 0.065 M or benzalkonium chloride at a concentration of up to about 0.1 M, and (c) glycerol at a concentration of up to about 5 M or trimethylamine N-oxide at a concentration of up to about 2 M or proline at a concentration of up to about 2 M, wherein the concentration of glycerol, trimethylamine N-oxide or proline mitigates the destabilizing effect of said benzyl alcohol or benzalkonium chloride.