Patent ID: 9012490
Filing Date: 2015-04-21
Classification: A61K,A61M,C07C,C07D

Abstract:
1. A method for treating cognitive decline in a subject having HIV, wherein the cognitive decline is mediated by the decrease of BDNF mRNA levels in the brain, the method comprising administering to a subject infected with HIV at least one compound of any of formulas (I) to (VIII), a pharmaceutically acceptable salt thereof, or combination thereof amount in a therapeutically effective amount to increase BDNF mRNA levels in the brain: each X is independently selected from H, CH n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include —CH or —CH where X is O, NH, S, or CH Y is O, NH, S, or CH n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include —CH or —CH where each X is independently selected from NH, O, or S; where R R n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include —CH or —CH where R R each R R n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include —CH or —CH where each R is independently selected from alkyl or phenyl, which may optionally be substituted at any position with halogen or alkyl having 1 to 3 carbons, n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include —CH or —CH salt thereof, or combination thereof.