Patent ID: 8268324
Filing Date: 2012-09-18
Classification: A61K,A61P,C07K,Y02A

Abstract:
1. A protein, or a salt thereof, comprising a mutant galectin 9 protein having β-galactoside binding activity and having the structure (N-CRD)-Linker-(C-CRD), wherein N-CRD (N-terminal Carbohydrate Recognition Domain) is a polypeptide having the amino acid sequence of SEQ ID NO: 3, a variant thereof differing from the amino acid sequence of SEQ ID NO: 3 by a deletion, substitution or addition of 1 to 8 amino acid residues and maintaining a carbohydrate recognition activity of N-CRD of natural galectin 9, or a variant thereof having an amino acid sequence at least 70% homologous to SEQ ID NO: 3 and maintaining a carbohydrate recognition activity of N-CRD of natural galectin 9; C-CRD (C-terminal Carbohydrate Recognition Domain) is a polypeptide having the amino acid sequence of SEQ ID NO: 4, a variant thereof differing from the amino acid sequence of SEQ ID: 4 by a deletion, substitution or addition of 1 to 21 amino acid residues and maintaining a carbohydrate recognition activity of C-CRD of natural galectin 9, or a variant thereof having an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and maintaining a carbohydrate recognition activity of C-CRD of natural galectin 9; and Linker is an amino acid sequence consisting of 2 arbitrary natural amino acid residues, or having the sequence Arg Ile Pro.