Patent ID: 6893633
Filing Date: 2005-05-17
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. A method of promoting the maturation of monocytcs into dendritic cells in a subject having cancer comprising: identifying a subject having cancer, administering at least one monocyte maturation-promoting agent selected from the group consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF), Interleukin-4 (IL-4), Interleukin-6 (IL-6), TNF-α, granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and Interleukin-18 (IL-18); and administering a reactive oxygen species (ROS) production or release inhibiting compound selected from the group consisting of histamine, histamine salts, histamine receptor agonist, serotonin, 5HT agonists, and an endogenous histamine releasing compound.