Patent ID: 8258312
Filing Date: 2012-09-04
Classification: C07D

Abstract:
1. A process for the preparation of Valsartan, comprising a) reacting a compound of formula II:  with tributyltin azide in a solvent; b) quenching the reaction with a base; c) treating the reaction mixture with charcoal and washing with organic solvent; d) adjusting the pH of the reaction mixture to 6.0-8.0 using an acid and treating with charcoal and filtering; e) adding a chelating agent to the reaction mixture; f) adjusting the pH to 3.0-5.0 using an acid; g) extracting the aqueous layer with an organic solvent; h) evaporating the solvent to obtain a residue; i) taking the residue in ethyl acetate and cooling; j) filtering and drying the precipitates.