Patent ID: 6075137
Filing Date: 2000-06-13
Classification: A61K,C07K,G01N

Abstract:
An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide having at least 80% identity to the amino acid sequence of SEQ ID NO:2, which may include up to n.sub.a amino acid alterations over the entire length of SEQ ID NO: 2, wherein n.sub.a is the maximum number of amino acid alterations, and is calculated by the formulan.sub.a .ltoreq.x.sub.a -(x.sub.a .multidot.y),in which x.sub.a is the total number of amino acids in SEQ ID NO:2, and y has a value of 0.80, wherein any non-integer product of x.sub.a and y is rounded down to the nearest integer prior to subtracting such product from x.sub.a.