Patent ID: 6613874
Filing Date: 2003-09-02
Classification: A61K,A61P,C07K

Abstract:
A cyclic peptide having the formula: wherein B is a bridge moiety selected from: E is selected from the group consisting of hydrogen; halo; â€”OR13; â€”SR13; â€”NR13R13â€²; â€”N(R13)SO2R13â€³; â€”SO2R13â€³; â€”SO2â€”NR13R13â€²; and â€”(CH2)rP(O)(OH)R15; r is 0 to 10; R15 is selected from the group consisting of â€”OH, hydrogen; alkyl; alkenyl; alkynyl; cyano; nitro; CF3; aryl; heteroaryl; cycloalkyl; and heterocycloalkyl; provided that when each X is hydrogen, E is not hydrogen; each R13 and R13â€² is independently selected from the group consisting of hydrogen, alkyl, acyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; and R13â€³ is selected from the group consistinig of hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; X1, X2, X3, and X4 which each represents the four substituents on the phenyl ring other than E, is independently selected from hydrogen; halo; OR8; â€”SR8; â€”NR8R8â€²; â€”N(R8)SO2R8â€³; â€”SO2R8â€³; â€”SO2â€”NR8R8â€²; and â€”(CH2)rP(O)(OH)R14 r is 0 to 10 and R14 is selected from the group consisting of â€”OH, hydrogen and alkyl; alkenyl; alklynyl; cyano; nitro, CF3; aryl, heteroaryl; cycloalkyl; and heterocycloalkyl; each R8 and R8â€² is independently selected from the group consisting of hydrogen, alkyl, acyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl and R8â€³ is selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; Z1, Z2, Z3, and Z4 is one or more substituents independently selected from the group consisting of hydrogen, hydroxy, halo, thiol, â€”Oâ€”R9, â€”SR9, â€”NR9R9â€², alkyl, acyl, alkenyl, alkynyl, cyano, nitro, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; each R9 and R9â€² is independently selected from hydrogen, alkyl, acyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; G is selected from a substituted or unsubstituted aryl or heteroaryl ring, the index q is from 1 to 3.