Patent ID: 8512706
Filing Date: 2013-08-20
Classification: A61K,A61P,C07K,Y10S

Abstract:
1. A composition comprising F(ab′) 2 antibody fragments substantially free from albumin and whole antibodies and substantially free of pyrogens, wherein the composition binds to a purified antigenic molecule or a mixture of antigenic molecules found in spider venom, and wherein the F(ab′) 2 antibody fragments are obtained by a method which comprises: (a) contacting a source of antibodies with pepsin under conditions to prepare an antibody digest containing F(ab′) (b) treating the antibody digest with two steps of ammonium sulfate precipitation, (i) one step at about 16% to about 22% weight by volume of ammonium sulfate, and (ii) another step at about 32% to about 38% weight by volume of ammonium sulfate, to thereby obtain a suspension containing F(ab′)