Patent ID: 7309615
Filing Date: 2007-12-18
Classification: B82Y,C07D,G01N,Y10S

Abstract:
1. A reagent for the detection or quantification of an analyte comprising a hydrophilic, high quantum yield acridinium compound attached to an analyte, an analyte analog, or a binding molecule for an analyte; wherein the acridinium compound comprises a carboxyl group at the C-9 position of the acridinium nucleus which is linked to a substituted aryl moiety to form a phenolic ester, said acridinium compound comprising electron-donating functional groups of the form —OR*, where R* is a group comprising a sulfopropyl moiety or ethylene glycol moieties, or a combination thereof, at the C-2 and/or the C-7 position of the acridinium ring, wherein the high quantum yield acridinium compound has a relative quantum light yield greater than 1 as compared with a corresponding acridinium compound without electron-donating functional groups at the C-2 and/or the C-7 position of the acridinium ring.