Patent ID: 7112438
Filing Date: 2006-09-26
Classification: C07K

Abstract:
1. A polypeptide comprising the amino acid sequence X 1 -X 2 Cys-X 3 -X 4 Trp-X 5 -X 6 -Pro-Cys-X 7 -X 8 (SEQ ID NO:2), wherein: X 1 is Arg or His; X 2 is Gly, Ala, Arg, Leu or Pro; X 3 is Gly or Phe; X 4 is Ala or Ser; X 5 is Phe or Leu; X 6 is Arg, Asn or His; X 7 is Ala, Asp, His, Leu, Phe, Pro or Tyr; and X 8 is Ala, Arg, Asn, Asp or His, wherein the polypeptide binds factor VIII and wherein a terminal amino acid residue comprises a chemical modification.