Patent ID: 8614295
Filing Date: 2013-12-24
Classification: A61K,A61P,C07K

Abstract:
1. An antagonistic antibody which binds human OX40 comprising a heavy chain and a light chain, wherein the variable domain of the heavy chain comprises a CDR having the sequence given in SEQ ID NO:1 for CDR-H1, a CDR having the sequence given in SEQ ID NO:2 or SEQ ID NO:20 for CDR-H2 and a CDR having the sequence given in SEQ ID NO:3 for CDR-H3 and wherein the variable domain of the light chain comprises a CDR having the sequence given in SEQ ID NO:4 or SEQ ID NO:21 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:6 for CDR-L3 .