Patent ID: 6316431
Filing Date: 2001-11-13
Classification: A61K,A61P

Abstract:
A method for the treatment of decreased androgen to estrogen ratio in men, said method comprising administering to the patient an effective amount of an aromatase inhibitor said aromatase inhibitor being a compound of formula (I) ##STR2##wherein R.sub.1 is hydrogen, methyl, methoxy, nitro, amino, cyano, trifluoromethyl, difluoromethyl, monofluoromethyl or halogen, R.sub.2 is a heterocyclic radical selected from 1-imidazolyl, triazolyl, tetrazolyl, pyrazolyl, pyrimidinyl, oxazolyl, thiazolyl, isoxazolyl and isothiazolyl; R.sub.3 is hydrogen or hydroxy; R.sub.4 is hydrogen; R.sub.5 is hydrogen or hydroxy; or R.sub.4 is hydrogen and R.sub.3 and R.sub.5 combined form a bond; or R.sub.3 is hydrogen and R.sub.4 and R.sub.5 combined form .dbd.O; R.sub.6 is methylene, ethylene, --CHOH--, --CH.sub.2 CHOH--, --CHOH--CH.sub.2 --, --CH.dbd.CH-- or --C(.dbd.O)--; or R.sub.4 is hydrogen and R.sub.3 and R.sub.5 combined is .dbd.CH-- or .dbd.CH--CH.sub.2 --; or a stereoisomer, or a non-toxic pharmaceutically acceptable acid addition salt thereof.