Patent ID: 6833381
Filing Date: 2004-12-21
Classification: A61K,A61P,C07D

Abstract:
A method for inhibiting a TNF-&agr; in mammals comprising administering to a mammal an effective amount of a heterocyclic compound having an angiotensin II antagonistic activity which is represented by the formula: wherein ring B is an optionally substituted nitrogen-containing heterocyclic ring, R1 is a group capable of forming an anion or a group capable of being converted into such a group, X denotes that a phenylene group and a phenyl group are bound directly or through a spacer having 2 or less of atomic chains, and n is an integer of 1 or 2, or its prodrug or a salt thereof, provided that the compound is not (5,7-dimethyl-1-{[2â€²-(1H-tetrazol-5-yl)-1,1â€²-biphenyl-4-yl]methyl}-3,4-dihydro-1,6-naphthylidine-2(1H)-one).