Patent ID: 7998685
Filing Date: 2011-08-16
Classification: A01K,A61K,A61P,C07K,C12N,G01N

Abstract:
1. A method of identifying a candidate compound as a modulator of body mass or adiposity in a mammal, comprising the steps of: (a) contacting the candidate compound with a G protein-coupled receptor (GPCR) comprising an amino acid sequence having at least 80% identity to SEQ ID NO: 2; wherein the receptor couples to a G protein; (b) determining the ability of the compound to inhibit or stimulate functionality of the GPCR; (c) administering a compound which inhibits or stimulates functionality of the GPCR in step (b) to a mammal; and (d) determining whether the compound modulates body mass or adiposity in said mammal.