Patent ID: 6733744
Filing Date: 2004-05-11
Classification: A61K,C07D,C09B

Abstract:
An indole compound having the formula wherein R37, R38, R39, R40, R41, R42, R43, R44 and R45, Y5, and Z5 are independently from the group consisting of â€”H, C1-C10 alkoxyl, C1-C10 polyalkoxyalkyl, C1-C20 polyhydroxyalkyl, C5-C20 polyhydroxyaryl, saccharides, amino, C1-C10 aminoalkyl, cyano, nitro, halogen, hydrophilic peptides, arylpolysulfonates, C1-C10 alkyl, C5-C20 aryl, â€”SO3T, â€”CO2T, â€”OH, â€”(CH2)aSO3T, â€”(CH2)aOSO3T, â€”(CH2)aNHSO3T, â€”(CH2)aCO2(CH2)bSO3T, â€”(CH2)aOCO(CH2)bSO3T, â€”(CH2)aCONH(CH2)bSO3T, â€”(CH2)aNHCO(CH2)bSO3T, â€”(CH2)aNHCONH(CH2)bSO3T, â€”(CH2)aNHCSNH(CH2)bSO3T, â€”(CH2)aOCONH(CH2)bSO3T, â€”(CH2)aPO3HT, â€”(CH2)aPO3T2, â€”(CH2)aOPO3HT, â€”(CH2)aOPO3T2, â€”(CH2)aNHPO3HT, â€”(CH2)aNHPO3T2, â€”(CH2)aCO2(CH2)bPO3HT, â€”(CH2)aCO2(CH2)bPO3T2, â€”(CH2)aOCO(CH2)bPO3HT, â€”(CH2)aOCO(CH2)bPO3T2, â€”(CH2)aCONH(CH2)bPO3HT, â€”(CH2)aCONH(CH2)bPO3T2, â€”(CH2)aNHCO(CH2)bPO3HT, â€”(CH2)aNHCO(CH2)bPO3T2, â€”(CH2)aNHCONH(CH2)bPO3HT, â€”(CH2)aNHCONH(CH2)bPO3T2, â€”(CH2)aNHCSNH(CH2)bPO3HT, â€”(CH2)aNHCSNH(CH2)bPO3T2, â€”(CH2)aOCONH(CH2)bPO3HT, and â€”(CH2)aOCONH(CH2)bPO3T2, â€”CH2(CH2â€”Oâ€”CH2)câ€”CH2â€”OH, â€”(CH2)dâ€”CO2T, â€”CH2â€”(CH2â€”Oâ€”CH2)eâ€”CH2â€”CO2T, â€”(CH2)fâ€”NH2, â€”CH2â€”(CH2â€”Oâ€”CH2)gâ€”CH2â€”NH2, â€”(CH2)hâ€”N(Ra)â€”(CH2)iâ€”CO2T, and â€”(CH2)jâ€”N(Rb)â€”CH2â€”(CH2â€”Oâ€”CH2)kâ€”CH2â€”CO2T; W5 and X5 are â€”CRcRd; V5 is a single bond or is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”Seâ€”, and â€”NRa; D5 is a single or a double bond; A5 and B5 are CRc; E5 is â€”Oâ€”; A5, B5, D5, and E5 may together form a 6 or 7 membered carbocyclic ring or a 6 or 7 membered heterocyclic ring optionally containing one or more oxygen, nitrogen, or sulfur atom; a, b, d, f, h, i, and j independently vary from 1-10; c, e, g, and k independently vary from 1-100; a5 and b5 vary from 0 to 5; Ra, Rb, Rc, and Rd are defined in the same manner as Y5; and T is either H or a negative charge.