Patent ID: 7989645
Filing Date: 2011-08-02
Classification: C07D

Abstract:
1. (S)-(+)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile or Escitalopram with chiral purity greater than 99.8% obtained without chiral chromatographic separation of (±)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile in more than 50% yield based on the S-enantiomer of the compound of formula IVa, wherein Z is a cyano group or a group that may be converted to a cyano group selected from the group consisting of halogen, —OH, —CHO, —CH wherein Y is O or S; R