Patent ID: 6610664
Filing Date: 2003-08-26
Classification: A61K,C07D,C07K,Y10T

Abstract:
A method comprising introducing into a subject a complex of a lipid having the structure A1 whereineach R is independently hydrogen or a lipohpilic moiety, provided that both R are not hydrogen; R1 and R2 are independently hydrogen, â€”(CH2)2â€”N(R4)2, â€”(CH2)zNR4â€”C(NH)â€”N(R5)2, or W1, provided that at least one of R1 and R2 is W1; each R3 is independently hydrogen, alkyl (C1-10), â€”CH2â€”(CF2)pâ€”CF3, aryl, a protecting group, or both R3 together are a protecting group, or one R3 is hydrogen and the other R3 is â€”C(O)CH2NH2 or â€”C(O)CHCH3NH2, provided that both R3 are not aryl; each R4 is independently hydrogen, alkyl (C1-6), a protecting group, â€”CH2â€”(CF2)pâ€”CF3, or both R4 together are a protecting group; each R5 is independently hydrogen, alkyl (C1-6), a protecting group, or both R5 together are a protecting group; each W1 is independently â€ƒm is an integer having the value 0, 1, 2, 3, or 4; n is an integer having the value 0, 1, 2, 3, or 4; p is an integer having the value 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; s is an integer having the value 0, 1, or 2; z is an integer having the value 1, 2, 3, or 4; and positions designated * are carbon atoms with linked substituents in the R, S or RS configuration; and a therapeutic agent, a nucleic acid or an oligonucleotide.