Patent ID: 7235523
Filing Date: 2007-06-26
Classification: A61K,A61P,C07K

Abstract:
1. A method for the treatment of hepatobiliary damage in a subject comprising (a) identifying a subject in need of treatment for hepatobiliary damage; (b) administering to the subject a therapeutically effective amount of a composition comprising a RON receptor tyrosine kinase inhibitor wherein the RON receptor tyrosine kinase inhibitor is an HGFL protein antagonist and wherein the HGFL protein antagonist comprises a polypeptide sequence of at least the C-terminal serine protease-like domain of an MSP beta-chain protein (SEQ ID NO:2); wherein the polypeptide comprises at least 9 contiguous amino acids of SEQ ID NO:2 and is less than 100 amino acids in length; wherein the polypeptide sequence is lacking at least one kringle region selected from the group comprising the 2 nd (ΔK2), 3 rd (ΔK3) or 4 th (ΔK4) kringle domains; and wherein the polypeptide is capable of binding the RON receptor and preventing activation of the RON receptor by HGFL; and (c) continuing the administration of the composition for a time sufficient to treat hepatobiliary damage in the subject.