Patent ID: 6355809
Filing Date: 2002-03-12
Classification: A61P,C07D

Abstract:
A process for the preparation of (2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl]pyrrolidine-2-carboxamide of the formula: or a solvate or hydrate thereof by cyclizing of (2S)-1-{[[4-chloro-2-(2-chlorobenzoyl)phenyl](3,4-dimethoxybenzenesulfonyl)amino]acetyl}pyrrolidine-2-carboxamide of the formula: in the presence of an alkali metal hydroxide in a mixture of water and a polyethylene glycol with an average molecular weight of between 200 and 600, wherein the reaction is carried out at a temperature of between 0Â° C. and 45Â° C.