Patent ID: 9102632
Filing Date: 2015-08-11
Classification: A61P,C07D

Abstract:
1. A method for treating diabetes associated with lack of insulin production or for treating type II diabetes, comprising administering to a subject in need thereof an effective amount of a compound of formula (I), or a racemic form, tautomer, enantiomer, diastereomer, epimer or polymorph thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof wherein n=0, 1, or 2; R1 is alkyl, alkenyl, or alkynyl, which is optionally substituted by one or more substituents Y; R2 is hydrogen, halogen, heteroaryl, or Z; R3 is hydrogen, halogen, aryl, heteroaryl, or Z, wherein aryl and heteroaryl groups are optionally substituted by one or more substituents Y; R4 is arylalkyl, aryloxyalkyl, arylalkoxyalkyl, arylthioalkyl, arylalkylthioalkyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heteroarylalkoxyalkyl, heteroarylthioalkyl, heteroarylalkylthioalkyl, heterocycloalkyl, heterocycloalkyloxyalkyl, heterocycloalkylalkoxyalkyl, heterocycloalkylthioalkyl, heterocycloalkylalkylthioalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkyloxyalkyl, cycloalkylalkoxyalkyl, cycloalkylthioalkyl, or cycloalkylalkylthioalkyl, which is optionally substituted by one or more substituents Y, wherein heteroaryl and heterocycloalkyl groups include one or more heteroatoms each selected from the group consisting of N, O and S, or is m=1-6; R7 and R8 are each independently hydrogen, aryl, heteroaryl, or Z, wherein aryl and heteroaryl groups are optionally substituted by one or more substituents Y; or R7 and R8 together constitute a heterocycle, which includes one or more heteroatoms each selected from the group consisting of N, O and S; p=1-6; R9 is aryl, heteroaryl, O—R10, or Z, wherein aryl and heteroaryl groups are optionally substituted by one or more substituents Y; R10 is hydrogen, alkyl, aryl, or arylalkyl, wherein alkyl, aryl, and arylalkyl groups are optionally substituted by one or more substituents Y; Z is alkyl, alkenyl, alkynyl, aryl, arylalkyl, aryloxyalkyl, arylalkoxyalkyl, arylthioalkyl, arylalkylthioalkyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heteroarylalkoxyalkyl, heteroarylthioalkyl, heteroarylalkylthioalkyl, heterocycloalkyl, heterocycloalkylalkyl, heterocycloalkyloxyalkyl, heterocycloalkylalkoxyalkyl, heterocycloalkylthioalkyl, heterocycloalkylalkylthioalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkyloxyalkyl, cycloalkylalkoxyalkyl, cycloalkylthioalkyl, or cycloalkylalkylthioalkyl, which is optionally substituted by one or more substituents Y, wherein heteroaryl and heterocycloalkyl groups include one or more heteroatoms each selected from the group consisting of N, O and S; Y is hydroxy, halogen, cyano, trifluoromethoxy, trifluoromethyl, carboxy, carboxy methyl, carboxyethyl, alkyl, alkoxy, alkylamino, aryl, aryl sulfonylalkyl, aryloxy, arylalkoxy, amino, NR5R6, azido, nitro, guanidino, amidino, phosphono, carbamoyl, alkylsulfonyl, alkylsulfinyl, or alkylthio, or two Y groups form a methylenedioxy; and R5 and R6 are independently hydrogen, alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, wherein alkyl, aryl and heteroaryl groups are optionally substituted by one or more substituents Y; or R5 and R6 together constitute a heterocycle; which includes one or more heteroatoms each selected from the group consisting of N, O and S.