Patent ID: 7396646
Filing Date: 2008-07-08
Classification: C12Q,Y10S

Abstract:
1. A method of generating an alien sequence comprising steps of: A) providing a naturally-occurring sequence; B) determining one or more natural sequence statistics of the naturally-occurring sequence; C) applying a Hidden Markov Model algorithm to the one or more natural sequence statistics of the naturally-occurring sequence to generate an alien sequence, wherein the sequence statistic is selected from the group consisting of: codon occurrence, codon boundary di-nucleotide frequencies, and combinations thereof; D) generating and displaying the alien sequence, with the proviso that, at an adjustable frequency, at least one of the natural sequence statistics of the naturally-occurring sequence is switched to a sequence statistic that is inversely proportional to the natural sequence statistic, such that the alien sequence comprises intermittent highly improbable sequence patterns or subsequences throughout its length.