Patent ID: 7514468
Filing Date: 2009-04-07
Classification: C07D

Abstract:
1. Compounds of general formula wherein X denotes an oxygen or sulphur atom, R R R a phenyl group mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C R R a cyano, nitro, amino, C a C a C a carboxy or C a C a 4- to 7-membered cycloalkyleneiminocarbonyl group wherein a 4- to 7-membered cycloalkyleneimino group wherein a C or R an N—(C a group of formula R R while the unsubstituted, mono- or disubstituted phenyl groups containedin the above definitions, whether singly bonded or fused on, may additionally be substituted by one or two fluorine, chlorine, bromine or iodine atoms or by one or two C the abovementioned alkyl groups including straight-chain and branched alkyl groups, wherein additionally one to 3 hydrogen atoms may be replaced by fluorine atoms, while, unless otherwise stated, the expression a heteroaryl group refers to a monocyclic 5- or 6-membered heteroaryl group optionally substituted in the carbon skeleton by a C and additionally any carboxy, amino or imino group present may be substituted by a group which can be cleaved in vivo, or may be present in the form of a prodrug, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, with the exception of the compounds (Z)-3-[1-(4-piperidinomethyl-phenylamino)-1-phenyl-methylidene]-6-chloro-2-indolinone and (Z)-3-[1-(4-piperidinomethyl-phenylamino)-1-phenyl-methylidene]-6-bromo-2-indolinone.