Patent ID: 8119340
Filing Date: 2012-02-21
Classification: A61P,C07K,G01N

Abstract:
1. A method of (a) determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL susceptible to treatment directed to eliminating idiotype-specific B cell receptor-bearing B-CLL cells, or (b) following the progression of treatment of B-CLL in a patient having a form of B-CLL susceptible to treatment directed to eliminating idiotype-specific B cell receptor-bearing B-CLL cells, the method comprising determining whether a B cell receptors on a B-CLL from the patient is encoded by antibody genes comprising a light chain antibody gene and a heavy chain antibody gene, wherein the light chain antibody gene and the heavy chain antibody gene are selected from the group consisting of V wherein if the B cell receptor on the B-CLL cells has an idiotype encoded by the antibody genes, the patient has a form of B-CLL susceptible to treatment directed to eliminating idiotype-specific B cell receptor-bearing B-CLL cells or the treatment of the patient has not eliminated the idiotype-specific B cell receptor-bearing B-CLL cells.