Patent ID: 8524709
Filing Date: 2013-09-03
Classification: A61P,C07D,C12Q

Abstract:
1. A method of treating a disease or disease symptom that is modulated by a kinase enzyme in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I), or pharmaceutical salt thereof, wherein the disease or disease symptom is selected from the group consisting of renal cell carcinoma, GI stromal tumor, pancreatic neuroendocrine tumor, lung cancer, colorectal cancer, age-related macular degeneracy (AMD), glioblastoma, ovarian cancer, and hepatocellular carcinoma; Cy is a cyclic structure that can be cycloalkyl, heterocyclic, or heteroaryl, each optionally substituted with Z R (1) hydrogen or R (2) —OH or —OR (3) —SH or —SR (4) —C(O) (5) —SO 6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) —Z (12) —P(O)(OR R (1) hydrogen or R′ (2) —OH or —OR (3) —SH or —SR (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) —Z (12) —P(O)(OR R (1) hydrogen or R (2) R (3) any two of R Z (1) hydrogen or Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z (13) any two of Z Z (1) a single bond; (2) —Z (3) —Z (4) —Z (5) —Z (6) —Z (7) —Z Z (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; each Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z each Z each Z each Z each Z each Z (2) —OH or —OZ (3) —SH or —SZ (4) —C(O) (5) —SO (6) halo; (7) cyano; (8) nitro; (9) —Z (10) —Z (11) oxo; (12) —O—C(O)—Z where Z where any two of Z provided said compound is other than a compound of formula IIa or IIb: