Patent ID: 6410724
Filing Date: 2002-06-25
Classification: C12Q

Abstract:
A composition for the predictive diagnosis of an hepatocellular carcinoma in a patient consisting essentially of a first isolated polynucleotide primer or a pair of isolated polynucleotide primers capable of specifically detecting or amplifying a first microsatellite DNA marker and a second isolated polynucleotide primer or a pair of isolated polynucleotide primers capable of specifically detecting or amplifying a second microsatellite DNA marker, wherein:said first microsatellite DNA marker is selected from the group consisting of D1S235, D1S238, D2S125, D2S336, D7S495, D8S263, D9S164, D9S273, and D17S928; and in that: said second microsatellite DNA marker is selected from the group consisting of D1S199, D1S235, D1S238, D1S247, D1S255, D1S436, D1S478, D1S2644, D1S2828, D2S125, D2S336, D4S400, D4S426, D4S1564, D4S1572, D4S1616, D4S2937, D4S2945, D6S305, D7S493, D7S495, D8S262, D8S263, D8S264, D8S277, D8S518, D8S1469, D8S1721, D8S1731, D8S1742, D8S1752, D8S1819, D9S164, D9S273, D13S284, D14S81, D14S265, D14S280, D14S292, D14S995, D16S402, D16S422, D16S505, D16S511, D16S3098, D17S786 and D17S928; and providing that said first and said second microsatellite DNA markers are not the same.