Patent ID: 8945546
Filing Date: 2015-02-03
Classification: A61K,A61P,C07K

Abstract:
1. A method of inhibiting an inflammatory or autoimmune response mediated by activated T cells or NK cells, comprising contacting the T cells or NK cells with an antibody, or antigen-binding portion thereof, which specifically binds IP-10 (SEQ ID NO: 121), such that the inflammatory or autoimmune response is inhibited, wherein the antibody or antigen-binding portion thereof: (a) comprises heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 5, 17, and 28, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 55, 66, and 77, respectively; (b) comprises heavy and light chain variable region sequences comprising SEQ ID NOs: 39 and 88, respectively; or (c) binds an epitope on human IP-10 (SEQ ID NO: 121) recognized by a reference antibody, wherein the reference antibody comprises heavy and light chain variable region sequences as set forth in SEQ ID NOs: 39 and 88, respectively.