Patent ID: 8642577
Filing Date: 2014-02-04
Classification: A61K,A61P,C12N

Abstract:
1. A method for the treatment of a poxvirus infection comprising administering an effective amount of a prodrug of cidofovir having the structure: or a pharmaceutically acceptable salt thereof, in combination or alternation with at least a second anti-pox virus agent to a host in need thereof, wherein the second anti-pox agent is Siga-246 (4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide), and the prodrug or a pharmaceutically acceptable salt thereof and the second anti-pox virus agent are each administered orally.