Patent ID: 6667025
Filing Date: 2003-12-23
Classification: A61K,A61P,Y10S

Abstract:
A method for identifying the presence or absence of accelerated lymphocyte homing immunosuppressive activity in a sample comprising:providing a mammal with transplanted tissue or cells, administering the sample to the mammal, assaying for the survival of the transplanted tissue or cells in the mammal following the administration, and assaying for the amount of circulating blood lymphocytes to the amount of lymphocytes in peripheral or mesenteric lymphoid tissue in the mammal; wherein a decrease in the amount of circulating blood lymphocytes and an increase in the amount of lymphocytes in the peripheral or mesenteric lymphoid tissue indicates the presence of accelerated lymphocyte immunosuppressive homing activity, and wherein the absence of a decrease in the amount of circulating blood lymphocytes and the absence of an increase in the amount of lymphocytes in the peripheral or mesenteric lymphoid tissue indicates the absence of accelerated lymphocyte immunosuppressive homing activity.