Patent ID: 8586619
Filing Date: 2013-11-19
Classification: A61P,C07D

Abstract:
1. A compound having a structural Formula (I), or a salt, solvate, ester, and/or prodrug thereof: wherein: (1) [6-(2-Methoxy-benzylcarbamoyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (2) 3-(4-Methyl-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (3) 3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (4) 4-Oxo-3-thiophen-2-ylmethyl-10-oxa-3-aza-tricyclo[5.2.1.0 (5) 3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (6) 1-(2-{[3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (7) Diisobutyl-{3-[(4-oxo-3-thiophen-2-ylmethyl-10-oxa-3-aza-tricyclo[5.2.1.0 (8) 3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (9) 3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (10) 3-Allyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (11) 3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (12) 3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (13) 3-tert-Butyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (14) 4-Oxo-3-propyl-10-oxa-3-aza-tricyclo[5.2.1.0 (15) 3-Benzyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (16) 4-Oxo-3-(tetrahydro-furan-2-ylmethyl)-10-oxa-3-aza-tricyclo[5.2.1.0 (17) 3-(4-Methyl-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (18) 3-Benzyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (19) 4-Oxo-3-pyridin-3-ylmethyl-10-oxa-3-aza-tricyclo[5.2.1.0 (20) 3-(4-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (21) 3-(2-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (22) 3-(2,3-Dimethyl-cyclohexyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (23) 4-Oxo-3-thiophen-2-ylmethyl-10-oxa-3-aza-tricyclo[5.2.1.0 (24) 4-Oxo-3-(tetrahydro-furan-2-ylmethyl)-10-oxa-3-aza-tricyclo[5.2.1.0 (25) 2-[2-Cyclohexylcarbamoyl-6-(3-methoxy-phenylcarbamoyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (26) 4-Oxo-3-pyridin-3-ylmethyl-10-oxa-3-aza-tricyclo[5.2.1.0 (27) 3-(4-Methyl-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (28) 3-(4-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (29) 3-(2-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (30) 3-(4-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (31) 4-Oxo-3-(tetrahydro-furan-2-ylmethyl)-10-oxa-3-aza-tricyclo[5.2.1.0 (32) 3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (33) 3-Benzo[1,3]dioxol-5-ylmethyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (34) 3-(4-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (35) 3-(3-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (36) 3-(2-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (37) 3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (38) 3-(4-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (39) 3-(2,3-Dimethyl-cyclohexyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (40) 3-(3-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (41) 3-Benzo[1,3]dioxol-5-ylmethyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (42) 4-Oxo-3-(1-phenyl-ethyl)-10-oxa-3-aza-tricyclo[5.2.1.0 (43) 3-(2,3-Dimethyl-cyclohexyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (44) 3-(3-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (45) 3-(4-Methyl-cyclohexyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (46) 3-(2-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (47) 3-(4-Fluoro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (48) 3-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (49) 3-(3-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (50) 3-(4-Chloro-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (51) 3-[2-(4-Chloro-phenyl)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (52) 3-(1-Methyl-3-phenyl-propyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (53) 3-[2-(Benzyl-methyl-amino)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (54) 3-[3-(Benzyl-methyl-amino)-propyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0 (55) 3-[2-(Benzyl-methyl-amino)-ethyl]-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0