Patent ID: 6740305
Filing Date: 2004-05-25
Classification: A61K

Abstract:
A method of measuring gastric emptying time comprising: providing to a patient a meal comprising a breath test food additive substrate, wherein said substrate is a linear acyl aminoacid peptidomimetic that includes a radioactive or non-radioactively labeled carbon atom, and wherein said substrate is selected from the group consisting of: whereR2=H, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl tert-butyl, isopentyl, isohexyl, phenyl, phenylmethyl; and R3=H, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl tert-butyl, isopentyl, isohexyl, phenyl, phenylmethyl, R4=acetyl; R5=H, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl tert-butyl, isopentyl, isohexyl, phenyl, phenylmethyl; and R6=H, if R5â‰ H; CH2-OH, CH2-SH, CH2-CH2-CH2-OH, CH2-CH2-Sâ€”CH3, CH2-COOR2, CH2-CH2-COOR2, CH2-CH2-CH2-COOR3, CH2-CH2-CONâ€”R3, CH2-CH2-CH2-NH2, or CH2-CH2-CH2-CH2-NH2 having said patient digest said meal so that the carbon labeled nutrients therein are absorbed in the small intestine and metabolized to labeled CO2; and detecting the level of CO2 in breath samples taken from the patient at periodic intervals to determine the rate of gastric emptying.