Patent ID: 7795033
Filing Date: 2010-09-14
Classification: C12Q,Y10T

Abstract:
1. A method of predicting the outcome of treatment with antidepressant medication in a patient comprising: (a) obtaining a sample of genetic material from the patient; (b) assaying the sample for the presence of a genotype in the patient which is associated with the outcome of treatment with antidepressant medication; and (c) predicting the outcome of treatment with antidepressant medication in the patient based on the presence of the genotype in the sample, wherein the genotype is characterized by a polymorphism in a gene having at least one marker, wherein the gene is selected from the group consisting of 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A); glutamine receptor, ionotropic, kainate 4 (GRIK4); B-cell leukemia/lymphoma 2 (BCL2); and a combination thereof, and wherein when the selected gene is HTR2A, the polymorphism is located within intron 2 of HTR2A, and the marker is selected from the group consisting of rs7997012, rs1928040, rs7333412, rs977003 and rs1745837, and/or the polymorphism is located within the 3′ untranslated region of HTR2A.