Patent ID: 6825201
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A compound of Formula I, including pharmaceutically acceptable salts thereof, wherein:Q is â€”represents a bond; A is phenyl; T is U is NR7; V is C(H)kR1 or N(R7â€²)k; W is CR3; X is CR4; Y is CR5; Z is CR6; k is 0; R1, R2, R3, R4, R5, and R6 are each independently selected from the group consisting of a bond, hydrogen, halogen, cyano, Xâ€²R24, C1-6alkyl, triazolyl, methyl-substituted triazolyl, C(O)NR28R29 and CO2R25; R7 and R7â€² are each independently selected from the group consisting of a bond and (CH2)rH, wherein r is 0-6; m and p are each 1; R9 is hydrogen or C1-6alkyl; R11, R12, R13, R14, R15, R16, R17, and R18 are each independently selected from hydrogen or C1-3alkyl; Xâ€² is selected from the group consisting of NR9 and O; R24 is hydrogen or C1-6alkyl; R25 is C1-6alkyl; R28 and R29 are independently selected from the group consisting of hydrogen, C1-6alkyl; provided when U is NR7; V is C(H)kR1; W is CR3; X is CR4; Y is CR5; Z is CR6; then R2 is not a bond; and provided that at any given time only one of the members selected from the group consisting of R1, R2, R3, R4, R5, R6, R7 and R7â€² is a bond, and further provided that said bond is the point of attachment to the adjacent carbon atom in the compound of Formula 1.