Patent ID: 6706254
Filing Date: 2004-03-16
Classification: A61K,C09B

Abstract:
The compound of formula wherein each W6 and X6 is C((CH2)OH)2; Y6 is â€”(CH2)2â€”CONH-Bm; Z6 is â€”(CH2)2â€”CONH-Dm; A4 is a single bond; A4, B4, C4, and D4 together form a 6-membered carbocyclic ring wherein B4, C4, and D4 are selected from the group consisting of â€”CR1R2, â€”CR1, and â€”C&boxH;O; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C20 aryl, C1-C10 alkoxyl, C1-C10 polyalkoxyalkyl, C1-C20 polyhydroxyalkyl, C5-C20 polyhydroxyaryl, C1-C10 aminoalkyl, cyano, nitro, halogen, saccharide, peptide, â€”CH2(CH2OCH2)bâ€”CH2â€”OH, â€”(CH2)aâ€”CO2H, â€”(CH2)aâ€”CONH-Bm, â€”CH2â€”(CH2OCH2)bâ€”CH2â€”CONH-Bm, â€”(CH2)aâ€”NHCO-Bm, â€”CH2â€”(CH2OCH2)bâ€”CH2â€”NHCO-Bm, â€”(CH2)aâ€”OH and â€”CH2â€”(CH2OCH2)bâ€”CO2H; a6 is 1; a is independently from 1 to 20: b is independently from 1 to 100; R67 is galactose; each R68 to R79 is hydrogen; Bm is Octreotate; and Dm is bombesin.