Patent ID: 8614332
Filing Date: 2013-12-24
Classification: A61P,C07F

Abstract:
1. A method for modulating glucokinase activity, which comprises administering to a mammalian patient in need thereof a therapeutically effective amount of a compound having the structure: or a pharmaceutically acceptable salt thereof, wherein: R R R where q=1, 2, or 3; R where q=1, 2, or 3, or where q=1, 2, or 3; where q=1, 2, or 3 or where q=1, 2, or 3; Z is a single bond, alkylene, or alkenylene wherein said alkylene or alkenylene may be optionally substituted with hydroxy, alkoxy, aminoalkyl, aminoaralkyl, aminoheteroaralkyl, aminoaryl, aminoheteroaryl, or carboxy; m is zero, 1, or 2; n is 1 or 2; R X is a single bond; Y is R s is zero; and R