Patent ID: 6017927
Filing Date: 2000-01-25
Classification: A61P,C07D,C09K

Abstract:
A quinuclidine derivative represented by the following formula (I): ##STR344## where the symbols in the formula have the following meanings: Ring A:(1) an aryl group having 6 to 14 carbon atoms(3) a cycloalkyl group having 3 to 8 carbon atoms(4) a cycloalrenye group having 3to 8 carbon atoms;wherein groups (1) to (5) above may be unsubstituted or substituted by one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a lower acyl group, a mercapto group, a lower alkylthio group, a sulfonyl group, a lower alkylsulfonyl group, a sulfinyl group, a lower alkylsulfinyl group, a sulfonamido group, a lower alkanesulfonamido group, a carbamoyl group, a thiocarbamoyl group, a mono- or di-lower aklylcarbamoyl group, a nitro group, a cyano group, an amino group, a mono- or di-lower alkylamino group, a methylenedioxy group, an ethylenedioxy group, and a lower alkyl group which may be substituted by a halogen atom, a hydroxyl group, a lower alkoxyl group, an amino group or mono- or di-lower alkylamino groupX: a single bond or a methylene group;R: a halogen atom, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a lower acyl group, a mercapto group, a lower alkylthio group, a sulfonyl group, a lower akylsulfonyl group, a sulfinyl group, a lower alkylsufinyl group, a sulfonamido group, a lower alkanesulfonamido group, a carbamoyl group, a thiocarbamoyl group, a mono- or di-lower alkylcarbamoyl group, a nitro group, a cyano group, an amino group, a mono- or di-lower alkylamino group, a methylenedioxy group, an ethylenedioxy group or a lower alkyl group which may be substituted by a halogen atom, a hydroxyl group, a lower alkoxy group, an amino group or a mono- or di-lower alkylamino group;l: 0 or 1;m: 0 or an integer of 1 to 3, andn: an integer of 1 or 2,a salt thereof, an N-oxide thereof, or a quaternary ammonium salt thereof.