Patent ID: 9156896
Filing Date: 2015-10-13
Classification: A61B,A61K,A61P,C07K,C12N

Abstract:
1. A method of treating a refractory wound, comprising: a. measuring the size of a skin wound upon initial presentation for treatment to obtain a first size measurement; b. administering compression bandaging to the wound; c. measuring the size of the wound after 2-4 weeks of administering the compression to obtain a second size measurement; d. determining that the second size indicator of the wound is within a predetermined range from about −30 to about +35% of the first size measurement, thereby identifying a refractory wound; and e. administering to the refractory wound a pharmaceutical composition comprising a pharmaceutical carrier suitable for topical administration of an anti-connexin polynucleotide to a connexin selected from connexin 26, connexin 30 and connexin 43.