Patent ID: 7358042
Filing Date: 2008-04-15
Classification: G01N

Abstract:
1. A method for detecting multidrug resistance in a test neoplastic cell, comprising: a) measuring a level of cell surface-expressed triosephosphate isomerase protein in the test neoplastic cell of a given origin or cell type, and b) comparing the level of cell surface-expressed triosephosphate isomerase protein in the test neoplastic cell to the level of cell surface-expressed triosephosphate isomerase in a control, nonresistant, neoplastic cell of the same origin or cell type, wherein the test neoplastic cell is multidrug resistant or has multidrug resistance potential if the level of cell surface-expressed triosephosphate isomerase in the test neoplastic cell is detectable greater than the level of cell surface-expressed triosephosphate isomerase in the nonresistant neoplastic cell.