Patent ID: 6645972
Filing Date: 2003-11-11
Classification: A61K,A61P,Y10S

Abstract:
A method for treating a patient with leukemia comprising administering to a patient that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor a therapeutically effective amount of a compound having the formula I: wherein B is cytosine or 5-fluorocytosine and R is selected from H, monophosphate, diphosphate, triphosphate, carbonyl substituted with a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, and wherein each Rc is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and an hydroxy protecting group.