Patent ID: 6103269
Filing Date: 2000-08-15
Classification: A61K,A61Q,Y10S,Y10T

Abstract:
An active compound-containing powder, granule or pellet, comprising a dispersion of at least one active compound or active compound having poor absorbability in vivo in a matrix which essentially includes a structure-forming agent comprising hydrophilic macromolecules which are selected from the group consisting of collagen, gelatin, fractionated gelatin, collagen hydrolyzates, succinylated gelatin, plant proteins, plant protein hydrolyzates, elastin hydrolyzates, and mixtures thereof, which is prepared by a process that comprises the step of:a) dissolving a structure-forming agent comprising hydrophilic macromolecules selected from the group consisting of collagen, gelatin, fractionated gelatin, collagen hydrolyzates, succinylated gelatin, plant proteins, plant protein hydrolyzates, elastin hydrolyzates, in an aqueous or aqueous-organic solvent;b) dispersing the active compound andc) adding the mixture of dissolved structure-forming agent and dispersed active compound dropwise to a deeply-cooled, easily evaporable liquid and thus forming powders, granules or pellets, andd) drying the powders, granules or pellets thus formed by evaporation or sublimation of the solvent in a customary manner until the solvent is removed.