Patent ID: 8703428
Filing Date: 2014-04-22
Classification: G01N

Abstract:
1. A method for characterizing the response of live-cells a to a stimulus, the method comprising: contacting the live-cells immobilized on a resonance waveguide grating (RWG) biosensor with a stimulus for a selected cellular target; interrogating and detecting the dynamic mass redistribution (DMR) of each individual cell of the stimulus contacted live-cells using a spatially resolved swept wavelength RWG biosensor imaging system, wherein the system uses a wavelength tunable light source to illuminate and interrogate the biosensor and a digital camera to detect and record the resonant wavelength image of the RWG biosensor with a pixelated resolution less than the average size of the individual live-cells; and determining the effect of the stimulus on the cell-signaling of the cellular target in the different individual cells among the stimulus contacted live-cells.