Patent ID: 7223872
Filing Date: 2007-05-29
Classification: A61P,C07K,Y02P

Abstract:
1. A process for the synthesis of compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein a compound of formula (II): wherein R1 represents a benzyl group or a linear or branched (C 1 –C 6 )alkyl group, is reacted with a compound of formula (III) having the S configuration: wherein X represents a halogen atom and R 2 represents a protecting group for the amino function, in the presence of a base, to yield, after deprotection of the amino function, a compound of formula (IV): which is reacted with ethyl 2-oxopentanoate under hydrogen pressure, in the presence of platinum-on-carbon, to yield a compound of formula (V): which is deprotected to yield the compound of formula (I).