Patent ID: 6348216
Filing Date: 2002-02-19
Classification: A61K,A61P,Y10S

Abstract:
A pharmaceutical tablet comprising a compressed composition substantially free of lactose and polyvinylpyrrolidone, said compressed composition comprising a granule comprised of:a) ibuprofen; b) hydrocodone bitartrate; c) colloidal silicon dioxide; d) a filler selected from the group consisting of microcrystalline cellulose and powdered cellulose; e) a disintegrant; and a f) starch; wherein the granule is formed by a wet granulation process and said granule comprises the ibuprofen and the hydrocodone bitartrate in a single phase; and wherein the composition further comprises an extra granule material comprising a lubricant; and wherein the composition flows well, has good compression performance and can be compressed over a wider range of compression forces with no substantial change in the disintegration time of the tablet; and wherein said ibuprofen, said hydrocodone bitartrate, and said lubricant are present in said tablet in a single phase.