Patent ID: 6017928
Filing Date: 2000-01-25
Classification: A61K,A61P,C07C,C07D,C07K

Abstract:
A method for treating a retroviral infection in a mammal comprising administering to said mammal:(a) an effective amount of a first retroviral protease inhibitor; and(b) an effective amount of a second retroviral protease inhibitor wherein said second retroviral protease inhibitor is effective against at least one retroviral strain that is resistant to said first retroviral protease inhibitor;wherein said first retroviral protease inhibitor is (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)-amino)ca rbonyl)valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-dipheny l-3-hydroxyhexane and said second retroviral protease inhibitor is N-tert-Butyl decahydro-2-(2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-L-asparag inyl)amino)butyl)-(4aR,8aS)-isoquinoline-3(S)-carboxamide.