Patent ID: 6646114
Filing Date: 2003-11-11
Classification: C07F,C07H

Abstract:
A reagent for the preparation of a mixed sequence oligonucleotide comprising a compound having the formula: wherein:each Q is independently O, S, CH2, CHF or CF2; each Bx is independently a nucleosidic base; each X is independently, OH, SH, SCH3, F, OCN, O(CH2)nNH2, C1 to C10 lower alkyl, C1 to C10 substituted lower alkyl, alkaryl, aralkyl, Cl, Br, CN, CF3, OCF3, O-alkyl, S-alkyl, N-alkyl, O-alkenyl, S-alkenyl, N-alkenyl, SOCH3, SO2CH3, ONO2, NO2, N3, NH2, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a conjugate, a reporter group, or an intercalator; W is a 3â€² hydroxyl protecting group; each Z is independently O or S; each T is independently a phosphorous blocking group each Y is H or a hydroxyl protecting group; and n is 1, 3, 5 or 7.