Patent ID: 8394947
Filing Date: 2013-03-12
Classification: C12N,C12Y

Abstract:
1. A composition comprising a first oligomeric compound and a second oligomeric compound, wherein: the first oligomeric compound is capable of hybridizing with at least a portion of the second oligomeric compound and to a selected target nucleic acid; each of the first and the second oligomeric compounds independently comprises a contiguous sequence of from about 19 to about 23 nucleosides linked by internucleoside linking groups; each of the first and the second oligomeric compounds optionally comprises a phosphate group, a 3′ or 5′-overhang or a conjugate group; and the first oligomeric compound having a plurality of modified ribofuranosyl nucleosides at defined positions, and the modified ribofuranosyl nucleosides consisting of 2′-OCH