Patent ID: 6746677
Filing Date: 2004-06-08
Classification: A61K,A61P,Y10S

Abstract:
A method for preventing or controlling helminthiasis, infection by acarids and arthropod endo- and ectoparasites and bacterial and viral disease in warm-blooded animals selected from the group consisting of sheep, cattle, horses, swine, deer, camels, poultry, dogs, cats and goats, which method comprises parenterally administering to the animals an effective amount of a vaccine composition which comprises on a weight basis about 0.05% to 2.5% of a compound selected from the group consisting of an LL-F28249&agr;-&lgr;, a 23-oxo or 23-imino derivative of an LL-28249&agr;-&lgr;, a milbemycin, an avermectin and mixtures thereof; about 0.1% to 6% of a water soluble organic solvent selected from the group consisting of benzyl alcohol, methanol, ethanol, a propylene glycol and glycerol formal; about 1% to 8% of a dispersing agent selected from the group consisting of a polyethylene oxide sorbitan mono-oleate, a polyoxyethylene alcohol, sodium lauryl sulfate, dioctyl sodium sulfosuccinate, a propylene glycol and an &agr;-hydro-&ohgr;-hydroxypoly(oxyethylene)poly(oxypropylene)poly(oxyethylene)block copolymer; about 10% to 50% of an adjuvant selected from the group consisting of aluminum hydroxide, potassium alum, protamine, aluminum phosphate and calcium phosphate; at least one disease antigen selected from the group consisting of Clostridium perfringens type A, B, C and D, Clostridium septicum, Clostridium tetani, Clostridium chauvoei, Clostridium novyi type B, Clostridium sordelli, Clostridium haemolytica, Pasteurella haemolytica, Pasteurella maltocida and Corynebacterium pseudotuberculosis; up to about 0.1% of a preservative; and saline or water or a mixture thereof.