Patent ID: 6825190
Filing Date: 2004-11-30
Classification: A61P,C07D

Abstract:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:A-B is Nâ€”O or Oâ€”N; Ar is an optionally substituted C5-10 aryl group; T is a C1-4 alkylidene chain wherein one or two methylene units of T are optionally and independently replaced by O, NR, S, C(O), C(O)NR, NRC(O)NR, SO2, SO2NR, NRSO2, NRSO2NR, CO2, OC(O), NRCO2, or OC(O)NR; n is zero or one; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; each R2 is independently selected from R, halo, CN, OR, N(R)2, SR, C(&boxH;O)R, CO2R, CONR2, NRC(&boxH;O)R, NRCO2(C1-6 aliphatic), OC(&boxH;O)R, SO2R, S(&boxH;O)R, SO2NR2, or NRSO2(C1-6 aliphatic); each R3 is independently selected from R, halo, CN, OR, N(R)2, SR, C(&boxH;O)R, CO2R, CONR2, NRC(&boxH;O)R, NRCO2(C1-6 aliphatic), OC(&boxH;O)R, SO2R, S(&boxH;O)R, SO2NR2, or NRSO2(C1-6 aliphatic); and each R is independently selected from hydrogen, a C1-8 aliphatic group, or two R on the same nitrogen are taken together with the nitrogen to form a 4-8 membered heterocyclic ring having 1-3 heteroatoms selected from nitrogen, oxygen or sulfur.