Patent ID: 6558710
Filing Date: 2003-05-06
Classification: A61K,A61P,Y10S

Abstract:
A composition for topical skin application comprising:a pharmaceutically acceptable carrier base including one or more topical solid or semi-solid materials; zinc oxide and optionally at least one additional zinc compound; and at least one amino acid which is a monocarboxylic amino acid capable of forming a complex with said zinc oxide; wherein said at least one amino acid is present in an amount corresponding to from approximately 2 to 20 molar equivalents relative to zinc in the composition, said composition contains from about 1 mg to about 20 mg zinc for each gram of said composition, wherein zinc of the zinc oxide and said at least one additional zinc compound which is optionally present has a modified irritant effect so as to cause minimal skin irritation, wherein said composition provides free zinc ions for local absorption and zinc availability on an order of one thousand times a normal blood level of zinc, and wherein said zinc oxide serves to form a complex of divalent zinc with said monocarboxylic amino acid and said complex is a zinc glycine complex having a formula Zn(C2H4NO2)2Â·nH2O in which n has a value of 1, 1Â½, or 2, combined with from 0.3 to 5.4 parts by weight of anhydrous glycine.