Patent ID: 9175082
Filing Date: 2015-11-03
Classification: A61K,A61P,C07K

Abstract:
1. A fully human antibody of an IgG class that binds to a PD-L1 epitope, that has a heavy chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 35, SEQ ID NO. 51, SEQ ID NO. 137, SEQ ID NO. 155, SEQ ID NO. 157, SEQ ID NO. 159, SEQ ID NO. 161, SEQ ID NO. 163, SEQ ID NO. 165, SEQ ID NO. 179, SEQ ID NO. 183, SEQ ID NO. 185, SEQ ID NO. 213, SEQ ID NO. 215, SEQ ID NO. 217, and SEQ ID NO. 219, and that has a light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 36, SEQ ID NO. 52, SEQ ID NO. 138, SEQ ID NO. 156, SEQ ID NO. 158, SEQ ID NO. 160, SEQ ID NO. 162, SEQ ID NO. 164, SEQ ID NO. 166, SEQ ID NO. 180, SEQ ID NO. 184, SEQ ID NO. 186, SEQ ID NO. 214, SEQ ID NO. 216, SEQ ID NO. 218, and SEQ ID NO. 220, and wherein the antibody has a heavy chain/light chain variable domain sequence selected from the group consisting of SEQ ID NO. 35/SEQ ID NO. 36 (called H6 herein), SEQ ID NO. 51/SEQ ID NO. 52 (called RC5 herein), SEQ ID NO. 137/SEQ ID NO. 138 (called SH1A1Q herein), SEQ ID NO. 155/SEQ ID NO. 156 (called SH1B3 herein), SEQ ID NO. 157/SEQ ID NO. 158 (called SH1D1 herein), SEQ ID NO. 159/SEQ ID NO. 160 (called SH1D2 herein), SEQ ID NO. 161/SEQ ID NO. 162 (called SH1D12 herein), SEQ ID NO. 163/SEQ ID NO. 164 (called SH1E1 herein), SEQ ID NO. 165/SEQ ID NO. 166 (called SH1G9 herein SEQ ID NO. 179/SEQ ID NO. 180 (called SH1E6 herein), SEQ ID NO. 183/SEQ ID NO. 184 (called SH1A2 herein), SEQ ID NO. 185/SEQ ID NO. 186 (called SH1B1 herein), SEQ ID NO. 213/SEQ ID NO. 214 (called H6B1L herein), SEQ ID NO. 215/SEQ ID NO. 216 (called H6A1 herein), SEQ ID NO. 217/SEQ ID NO. 218 (called H6B1 herein), and SEQ ID NO. 219/SEQ ID NO. 220 (called H6B2 herein).