Patent ID: 6441035
Filing Date: 2002-08-27
Classification: A61K,A61P,C07C

Abstract:
A composition for the treatment of dry eye and other disorders requiring the wetting of the eye comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of one or more compounds of the following formula I: wherein: R1 is CO2R, wherein R is H or CO2R forms an ophthalmically acceptable salt or an ophthalmically acceptable ester; K is C3-C6 alkyl, alkenyl, alkynyl or alkenyl group; A and X are the same or different and are a direct bond, CH2, NR7, O or S, with the proviso that at least one of A and X is NR7; B is H, or BB together comprises a double bonded O, S or NR8, with the proviso that BB comprises a double bonded O, S, or NR8 when A and X are the same or different and are NR7, O or S; wherein: NR7 and NR8 are the same or different and comprise a functionally modified amino group; p is 0 or 1; Dâ€”E and Gâ€”H are the same or different and are CH&boxH;CH or Câ‰¡C; and Y is