Patent ID: 6599887
Filing Date: 2003-07-29
Classification: A61K,B82Y,C07H

Abstract:
A method for inhibiting a viral polymerase in a virally infected mammalian cell without killing the cell, said method comprising administering to a mammal in need thereof an effective antiviral amount of a liponucleotide compound comprising:an antiviral nucleoside analogue having an ability to selectively inhibit said viral polymerase enzyme without killing the cell; and a lipid moiety selected from the group consisting of glycerolipids having the structure â€ƒwherein said R1 and R2 independently have from 0 to 6 sites of unsaturation, and have the structure CH3â€”(CH2)aâ€”(CH&boxH;CHâ€”CH2)bâ€”(CH2)câ€”Y wherein the sum of a and c is from 1 to 23; and b is 0 to 6; and wherein Y is selected from the group consisting of â€”CH2â€”O, â€”CH&boxH;CHâ€”Oâ€”, â€”CH2â€”Sâ€”, and â€”CH&boxH;CHâ€”Sâ€”; wherein the antiviral nucleoside analogue is covalently bound to the lipid moiety through a mono-phosphate linkage to the 5â€² carbon of the pentose residue of the nucleoside analogue corresponding to the 5â€² carbon of naturally occurring nucleosides.