Patent ID: 7915306
Filing Date: 2011-03-29
Classification: A61P,C07D

Abstract:
1. A pharmaceutical composition for systemic administration comprising a pharmaceutically suitable carrier or diluent and a compound having the structure: or a pharmaceutically acceptable salt or ester thereof; wherein R R R R R R n is 1; R R R wherein R wherein X —N(alkyl), or wherein X p is 2-10, and R R R X is O; Y is CHR wherein each occurrence of R wherein oxygen protecting groups are selected from the group consisting of methyl ethers, methoxymethyl ether, methylthiomethyl ether, benzyloxymethyl ether, p-methoxybenzyloxymethyl ether, ethyl ethers, benzyl ethers, silyl ethers, trimethylsilyl ether, triethylsilylether, triisopropylsilyl ether, t-butyldimethylsilyl ether, tribenzyl silyl ether, t-butyldiphenyl silyl ether, esters, formate, acetate, benzoate, trifluoroacetate, dichloroacetate, carbonates, cyclic acetals and ketals and wherein nitrogen protecting groups are selected from the group consisting of carbamates, Troc, amides, cyclic imides, N-alkyl amines, N-aryl amines, imines, and enamines; and wherein C