Patent ID: 9156875
Filing Date: 2015-10-13
Classification: A61K,A61P,C07H,C12N,Y02A

Abstract:
1. A method of inducing a Th-1 type immune response in a subject in need thereof, said method comprising the step of administering to the subject an amount of an isolated oligoribonucleotide (ORN) effective to induce said Th-1 type immune response in the subject, wherein said ORN comprises a 5′-triphosphate analog provided as: or a pharmaceutically acceptable salt thereof, wherein X X X each Y is independently selected from O, S, and NH; and each Z is independently selected from H, OH, SH, NH n is an integer between 0 and 3, inclusive, provided that n is 0 only when X with the proviso that the 5′-triphosphate analog is not 5′-triphosphate.