Patent ID: 7468378
Filing Date: 2008-12-23
Classification: A61P,C07D

Abstract:
1. A compound of Formula (I) wherein: R and is attached to the 2 or 3 position of the quinoline group of Formula (I); m is an integer from 0 to 2; n is an integer from 0 to 4; p is an integer from 0 to 5; q is an integer from 0 to 3; r is a bond or an integer from 1 to 3; X is —N— or C(R X R 2 , R 7 , R 8 and R 9 are each independently selected from the group consisting of halo, —OH, —CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-, alkoxyalkyl- having 2 to 4 carbon atoms, halo-substituted(C 1 -C 4 )alkyl-, halo-substituted(C 1 -C 4 )alkoxy-, (C 1 -C 4 )alkylthio-, hydroxy(C 1 -C 4 )alkyl-, benzyloxy-, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, —C(O)N(R c )(R 11 ), —N(R 11 )C(O)R 12 , —N(R 11 )CO 2 R 12 , —N(R 11 )S(O) s R 12 , —C(O)R 12 , —CO 2 R 12 , —OC(O)R 12 , —SO 2 N(R c )(R 11 ) and —S(O) v R 12 ; each R s is the integer 1 or 2; v is an integer from 0 to 2; R R R R R Y is selected from the group consisting of H, (C each R each R R R where the (C the (C the phenyl group and the phenyl moiety of the phenylalkyl group are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, (C R where the (C the phenyl group and the phenyl moiety of the phenylalkyl group are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, (C R R R R where the (C the phenyl group and the phenyl moiety of the phenylalkyl group are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, (C R where the (C the (C the phenyl group and the phenyl moiety of the phenylalkyl group are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, (C