Patent ID: 7727554
Filing Date: 2010-06-01
Classification: A61K,A61P,B82Y,Y10S

Abstract:
1. A sustained-release nanoparticle composition comprising a therapeutic agent and a cross-linked copolymer of N-isopropylacrylamide, N-vinyl pyrrolidone and polyethylene glycol-maleic acid conjugate in nanoparticle form, wherein the weight per weight ratio of the N-isopropylacrylamide, N-vinyl pyrrolidone and polyethylene glycol-maleic acid conjugate is 70-90:9-20:1-10, said therapeutic agent being encapsulated in said copolymer and said nanoparticle composition being effective to release said therapeutic agent for more than three weeks and to release more than 80% of said therapeutic agent within twenty-eight days.