Patent ID: 6077844
Filing Date: 2000-06-20
Classification: A61P,C07D

Abstract:
A compound, and pharmaceutically acceptable salts thereof, having the formula: ##STR50## wherein X and Y are the same or different and are selected from the group consisting of OH and NH.sub.2 ;wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is selected from the group consisting of a single bond and a double bond, L and M are carbon when the bond is a double bond, and L and M are CH when the bond is a single bond;wherein Z.sub.4, Z.sub.5 and Z.sub.6 are different and are selected from the group consisting of R.sub.4, R.sub.5 and ##STR51## wherein A is selected from the group consisting of CH, sulfur and zero; wherein B is selected from the group consisting of sulfur, nitrogen, oxygen, CH, N--CH.sub.2, CH.sub.2 --N, CH.sub.2 --CH.sub.2, and zero;wherein R.sub.1 is selected from the group consisting of hydrogen, a lower alkyl group, a nitroso group, a formyl group and zero, and R.sub.1 is zero when B is sulfur, oxygen or zero;wherein R.sub.2 is selected from the group consisting of a lower alkyl group, p-aroyl-L-glutamate, an aryl group, an alkylaryl group, a substituted aryl group, a substituted alkylaryl group, a diaryl group, a triaryl group, an alkyldiaryl group, an alicyclic hydrocarbon group, an alkyltriaryl group, a substituted diaryl group, and a substituted triaryl group, and each substituent of the substituted aryl group, diaryl group, triaryl group, or the substituted alkylaryl group, alkyldiaryl group, or alkyltriaryl group is the same or different and is selected from the group consisting of a lower alkyl group, an alkyl group, an alkoxy, an alkoxyaryloxy group, a halogen and zero;wherein R.sub.3 is selected from the group consisting of hydrogen, a lower alkyl group and zero, and R.sub.3 is zero when A is zero;wherein R.sub.4 is selected from the group consisting of hydrogen and a lower alkyl group;wherein R.sub.5 is selected from the group consisting of hydrogen and a lower alkyl group;where R.sub.4 is the same or different than R.sub.5 ;wherein each of said R.sub.4, R.sub.5 and ##STR52## substituents is used once; and wherein each lower alkyl group is independently selected from the group consisting of lower alkyl groups having from about 1 to 6 carbons.