Patent ID: 7998960
Filing Date: 2011-08-16
Classification: B01J,C07D,C12Q,G01N

Abstract:
1. A method for purifying plasminogen or a protein that is a plasminogen analogue, wherein said method comprises contacting a sample containing plasminogen or a plasminogen analogue with an affinity adsorbent of formula II wherein one X is N and the other X is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is OH or a primary amino; and q is 2 to 6; whereby plasminogen or a plasminogen analogue present in the sample binds to the affinity adsorbent of formula II and wherein said method further comprises removing the plasminogen, or analogue thereof, from the affinity adsorbent to obtain plasminogen, or analogue thereof, of greater than 85% purity.