Patent ID: 6509459
Filing Date: 2003-01-21
Classification: C07H,Y02P

Abstract:
A process for synthesizing an oligonucleotide, the process comprising coupling to a nucleoside a nucleoside synthon having a nucleoside base protecting group having the structure wherein n1, n2 and n3 are independently 0-10, wherein a, b, c, d and e are each independently hydrogen, carbon or nitrogen, and wherein the ring structure bearing substituent R3 is aromatic or heterocyclic, wherein the nitrogen displayed is the protected amino moiety of the nucleoside base, wherein R1, R2 and R3 are independently hydrogen, or an alkyl, aryl, aralkyl, ether, hydroxy, nitrile, nitro, ester, carboxyl, or aldehyde group, and wherein dotted lines represent alternative exocyclic or endocyclic double bonds; and removing the nucleoside base protecting group in ammonia gas.