Patent ID: 6407132
Filing Date: 2002-06-18
Classification: A61P,C07D,Y10S

Abstract:
A compound of the formula wherein R1 is selected from C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 alkylthio, carboxy, carboxy(C1 to C6)alkyl, formyl, C1 to C6 alkylcarbonyl, C1 to C6 alkylcarbonylalkoxy, nitro, trihalomethyl, hydroxy, amino, C1 to C6 alkylamino, di(C1 to C6 alkyl)amino, aryl, C1 to C6 alkylaryl, halo, sulfamoyl and cyano;R2 represents a bond or C1 to C5 hydrocarbylene; R3 is selected from the groups recited above for R1; R4 represents a bond or C1 to C5 hydrocarbylene; R5 is hydrogen, C1 to C3 alkyl, R8â€”Oâ€”(C1 to C3)alkyl (wherein R8 is hydrogen or C1 to C3 alkyl), aryl, aryl(C1 to C3)alkyl or heterocyclic(C1 to C3)alkyl; R6 represents a bond or â€”NR9â€”, wherein R9 is any of the groups recited above for R5; R7 is cycloalkyl(C1 to C3 alkyl), phenyl (C1 to C3 alkyl), naphthyl or naphthyl(C1 to C3)alkyl, optionally substituted by C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 alkylthio, carboxy, carboxy(C1 to C6)alkyl, formyl, C1 to C6 alkylcarbonyl, C1 to C6 alkylcarbonylalkoxy, nitro, trihalomethyl, hydroxy, amino, C1 to C6 alkylamino, di(C1 to C6 alkyl)amino, halo, sulfamoyl or cyano; a is from 0 to 2; and b is from 0 to 3; or a pharmaceutically acceptable salt thereof.