Patent ID: 6653471
Filing Date: 2003-11-25
Classification: A61P,C07D

Abstract:
A compound of the formula or a pharmaceutically acceptable salt thereof wherein: the b-ring is a 7 membered ring with one nitrogen; E represents (CR1R2)k, â€”CR1&boxH;CR2â€”, â€”N&boxH;CR1â€”, â€”CR1&boxH;Nâ€”, â€”NRâ€²â€”(CR1R2)â€”, or â€”(CR1R2)â€”NRâ€²â€”, wherein R1 and R2 independently represent hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono- or di- (C1-C6)alkylamino, C2-C6alkenyl, C2-C6alkynyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, amino(C1-C6)alkyl, or mono- or di(C1-C6)alkylamino(C1-C6)alkyl, or phenyl, pyridyl, phenyl(C1-C6)alkyl, or pyridyl (C1-C6) alkyl, where each phenyl or pyridyl is optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, and mono- or di(C1-C6)alkylamino; k is 2; Râ€² represents hydrogen, C1-C6 alkyl, C1-C6 alkanoyl, C1-C6 alkoxy(C1-C6)alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, amino(C1-C6)alkyl, or mono- or di(C1-C6)alkylamino(C1-C6)alkyl, or aryl, heteroaryl, aryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl, where each aryl and heteroaryl is optionally substituted with up to 3 groups independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, and mono- and di(C1-C6)alkylamino; G is oxygen or NH; J represents (CR5R6)d where d is 1 ; and R5 and R6 together form a carbonyl group; or R5 and R6 are independently hydrogen or R100, where each R100 is independently selected from halogen, hydroxy, nitro, cyano, R10, amino, â€”NH(R10), â€”N(R10)(R10), â€”COOH, â€”O(R10) , â€”SO2NH2, â€”SO2NH(R10) , â€”SO2N(R10)(R10), â€”NHCO(R10), â€”N(R10)CO(R10), â€”NHCO2(R10), â€”N(R10)CO2(R10), â€”NNSO2(R10), â€”N(R10)SO2(R10), â€”SO2NHCO(R10) , â€”SO2N(R10)CO(R10), â€”CONHSO2(R10), â€”CON(R10)SO2(R10), â€”CONH2, â€”CONH(R10), â€”CON(R10)(R10), â€”CO2(R10), â€”CO(R10), â€”SR10, SO(R10), â€”SO2(R10), aryl having from 1 to 3 rings, and heteroaryl, said heteroaryl having from 1 to 3 rings, 5 to 7 ring members in each ring, and in at least one of said rings from 1 to about 3 heteroatoms selected from nitrogen, oxygen and sulfur, and where each aryl and heteroaryl is optionally substituted with 1, 2, or 3 groups independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, and mono- or di(C1-C6)alkylamino; each R10 is independently a straight, branched, or cyclic alkyl group having up to 8 carbon atoms, contains zero or one or more double or triple bonds, and is optionally substituted with one or more substituents independently selected from hydroxy, oxo, halogen, amino, mono- or di-(C2-C6)alkylamino, cyano, nitro, C1-C6alkoxy, â€”COOH, â€”SO2NH2, â€”SO2NH(C1-C6 alkyl), â€”SO2N(C1-C6alkyl)(C1-C6alkyl), â€”NHCO(C1-C6alkyl), â€”N(C1-C6alkyl)CO(C1-C6alkyl), NHCO2(C1-C6alkyl), â€”N(C1-C6alkyl)CO2(C1-C6alkyl), â€”NHSO2(C1-C6alkyl), â€”N(C1-C6alkyl)SO2(C1-C6alkyl), â€”SO2N(C1-C6alkyl)CO(C1-C6alkyl), â€”SO2NHCO(C1-C6alkyl), â€”CON(C1-C6alkyl)SO2(C1âˆ C6alkyl), â€”CONHSO2(C1-C6alkyl), â€”CONH2, â€”CONH(alkyl), â€”CON(alkyl)(alkyl), â€”CO2(alkyl), â€”CO(alkyl), â€”SO0-2(C1-C6alkyl), and C3-C7cycloalkyl; the group â€ƒis the A ring and represents an optionally substituted saturated, partially unsaturated, or aromatic heterocyclic ring containing at least one nitrogen, oxygen, or sulfur atom, where the A ring is optionally substituted with up to three groups independently selected from R100; V is nitrogen, carbon, or CH; Y is carbon or CH; X is hydrogen, hydroxy, amino, mono- or di(C1-C6) alkylamino, C1-C6alkyl, or C1-C6 alkoxy; T is hydrogen, halogen, hydroxy, amino, mono- or di(C1-C6) alkylamino, C1-C6 alkyl, or C1-C6 alkoxy; Q is a saturated carbocyclic or heterocyclic group, partially unsaturated carbocyclic or heterocyclic group, an aryl group, or heteroaryl group, where each group has from 1 to 3 rings where each ring contains from 3 to 8 ring members, and where each heterocyclic and heteroaryl group contains at least one ring having from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; and where each carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally substituted with 1, 2, or 3 groups independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, oxo, cyano, nitro, amino, C1-C6 haloalkyl, C1-C6 haloalkoxy, and mono- or di(C1-C6) alkylamino; W is a bond, oxygen, NH, sulfur, â€”CH&boxH;CHâ€”, â€”Câ‰¡Câ€”, or CR7R8 where R7 and R8 are the same or different and represent hydrogen, C1-C6 alkyl, halo(C1-C6)alkyl, amino(C1-C6)alkyl, hydroxy(C1-C6)alkyl, or C1-C6 alkoxy(C1-C6)alkyl, or CR7R8 represents C3-C7 cycloalkyl; Z is hydrogen, hydroxy, hydroxy(C1-C6)alkyl, C1-C6 alkoxy, â€”CO(C1-C6)alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl (C1-C6)alkyl, C3-C7 cycloalkyl(C1-C6)alkoxy, amino, mono- or di(C1-C6) alkylamino, or NR11 COR12 where R11 and R12 are the same or different and represent hydrogen or C1-C6 alkyl, or NCOR11R12 represents a heterocycloalkanone ring, or Z is a saturated carbocyclic or heterocyclic group, a partially unsaturated carbocyclic or heterocyclic group, an aryl group, or a heteroaryl group, where each group has from 1 to 3 rings where each saturated ring contains from 3 to 8 ring members and each aromatic or partially unsaturated ring contains from 5-8 ring members, and where each heterocyclic and heteroaryl group contains at least one ring having from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; and where each carbocyclic, heterocyclic, aryl, and heteroaryl group is optionally substituted with 1, 2, or 3 groups independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, C1-C6 haloalkyl, C1-C6 haloalkoxy, and mono- or di(C1-C6)alkylamino; â€ƒindependently represent saturated carbon chains optionally substituted with one or more substituents independently selected from halogen, cyano, nitro, amino, mono- or di(C1-C6)alkylamino, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkyl, and C3-C7 cycloalkyl; m is 0, 1, 2, or 3; and n is 0, 1, 2, or 3; provided that when V is nitrogen, E does not contain nitrogen.