Patent ID: 6528514
Filing Date: 2003-03-04
Classification: A61K,A61P,C07D,C07K

Abstract:
A method for inhibiting IgE antibody production in a patient, which comprises administrating to the patient an IgE antibody production inhibiting effective amount of a heterocyclic amide compound of the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; wherein R represents a hydrogen atom, alkyl, â€”CHO, â€”COOH, â€”CONH2, â€”COR , â€”COOR1, â€”CONHOR1, â€”CONHR1, â€”CONR1R1â€², â€”CONHSO2R1, COSR1, â€”COCOR2, â€”COCOOR2, â€”CONHCOOR2, â€”COCONR3R4, â€”CSXR1, â€”SO2WR1, â€”SO2NR1R1â€² or â€”SO2E; R1 and R1â€² may be the same or different and each represents alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle or heterocyclic alkyl; R2, R3 and R4 may be the same or different and each represents a hydrogen atom, alkyl or arylalkyl, or R3 and R4 of â€”NR3R4 may be combined with each other to form a heterocycle; X represents a single bond, an oxygen atom, a sulfur atom, or â€”NHâ€”; W represents a single bond, â€”NHâ€”, â€”NHCOâ€”, â€”NHCOOâ€”, or â€”NHCONHâ€”; E represents hydroxyl group or amino; R5 and R7 may be the same or different and each represents a hydrogen atom or alkyl, or one of R5 and R7 represents aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl or heteroarylalkenyl, with each of the remaining two representing a hydrogen atom; M represents a nitrogen atom; Y represents cycloalkyl, aryl or heteroaryl; Z represents a hydrogen atom, â€”CF2R8, â€”CF2CONR9R10, â€”CF2COOR9, â€”COOR9, â€”CONR9R10, a group of the following formula (i), a group of the formula (ii), or a group of the following formula (iii); R8 represents a hydrogen atom, halogen, alkyl, perfluoroalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxyalkyl, hydroxyalkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl or heteroarylalkenyl; R9 and R10 may be the same or different and each represents a hydrogen atom, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclic alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl or heteroarylalkenyl, or R9 and R10 of â€”NR9R10 may be combined with each other to form a heterocycle; â€ƒwherein a, b, c, and d respectively represents a carbon atom or one of a, b, c, and d represents a nitrogen atom with each of the remaining three representing a carbon atom; R11, R12, R13 and R14 may be the same or different and each represents a hydrogen atom, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, halogen, trifluoromethyl, cyano, nitro, â€”NR17R17â€², â€”NHSO2R17, â€”OR17, â€”COOR17, â€”CONHSO2R17 or â€”CONR17R17â€²; provided that when one of a, b, c and d represents a nitrogen atom, R11, R12, R13 or R14 combined to the nitrogen atom mentioned for a, b, c, or d does not exist; R15 and R16 may be the same or different and each represents a hydrogen atom, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, halogen, trifluoromethyl, cyano, nitro, â€”NR17R17â€², â€”NHSO2R17, â€”OR17, â€”COOR17, â€”CONHSO2R17 or â€”CONR17R17â€²; R17 and R17â€² may be the same or different and each represents a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl or trifluoromethyl, or R17 and R17â€² of â€”NR17R17â€² may be combined with each other to form a heterocycle; A represents an oxygen atom, a sulfur atom or â€”NR18â€”; R18 represents a hydrogen atom, alkyl, cycloalkyl or cycloalkylalkyl; n represents 0 or 1; said alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heterocycle and heterocyclic alkyl may be substituted by one or more substituents respectively.