Patent ID: 6294541
Filing Date: 2001-09-25
Classification: A61P,C07D

Abstract:
A compound of the formula (III): ##STR10##whereinR.sub.3 represents a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, halogen, C.sub.1-10 haloalkyl, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2,or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CH.dbd.NOH, CH.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1 -.sub.4), optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 cycloalkoxy; a five to seven membered heterocyclyl ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms; and heterocyclylalkyl (C.sub.1 -C.sub.4) wherein said heterocyclyl moiety is a five to seven membered ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms;R.sub.8 represents H or a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, halogen, C.sub.1-10 haloalkyl, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2,or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, C.sub.1-6 alkoxy, C.sub.3-6 cycloalkoxy, CH.dbd.NOH, CH.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1 -.sub.4), optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, nitro, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 cycloalkoxy; a five to seven membered heterocyclyl ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms; and heterocyclylalkyl (C.sub.1 -C.sub.4) wherein said heterocyclyl moiety is a five to seven membered ring having at least one carbon atom and up to three nitrogen atoms, up to two oxygen atoms, and up to two sulfur atoms;provided that when R.sub.8 is H, R.sub.3 is not methyl;and pharmaceutically acceptable salts thereof.