Patent ID: 7514416
Filing Date: 2009-04-07
Classification: A61K,A61P,C12N

Abstract:
1. A method of suppressing growth of pancreatic tumors or cancer cells having a K-ras gene point mutation in a mammal, comprising: administering therapeutically effective amounts of adenoviral vector and antisense K-ras expressing vector to pancreatic cancer cells of the mammal via intratumoral administration, wherein the adenoviral vector comprises a DNA sequence encoding human IFN-alpha and operably linked to a promoter, wherein the pancreatic cancer cells to which the adenoviral vector is administered express the human IFN-alpha; and the antisense K-ras expressing vector comprises an antisense K-ras nucleotide sequence operably linked to a promoter, wherein the pancreatic cancer cells to which the anti-sense K-ras expressing vector is administered express the antisense K-ras nucleotide sequence; whereby expression of the human IFN-alpha and the antisense K-ras nucleotide sequence suppresses growth of pancreatic tumor or cancer cells in the mammal.