Patent ID: 6458959
Filing Date: 2002-10-01
Classification: A61P,C07D

Abstract:
A compound of the formula: whereinR is selected from the group consisting of hydrogen. lower alkyl, amino, lower alkylamino, di(lower alkyl)amino, lower alkanoylamino, (lower alkoxycarbonyl)amino, di(lower alkoxycarbonyl)amino and {(lower alkylamino)carbonyl}amino; and Z is C(O)â€”NR2BR3B wherein: R2B is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, phenyl(lower alkyl), phenyl(lower alkyl) monosubstituted or disubstituted on the aromatic portion thereof with a halo hydroxy, lower alkoxy, lower alkyl or trifluoromethoxy; lower cycloalkyl, (lower cycloalkyl)-(lower alkyl) or {1-hydroxy-(lower cycloalkyl}-(lower alkyl); and R3B is lower alkyl, phenyl(lower alkyl), phenyl(lower alkyl) monosubstituted or disubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy, lower alkyl or trifluoromethoxy; 1-indanyl, 2-indanyl, lower cycloalkyl, (lower cycloalkyl)-(lower alkyl) or {1-hydroxy-(lower cycloalkyl)}-(lower alkyl); or R3B is: â€ƒwherein R4B is hydrogen, lower alkyl, phenyl(lower alkyl), phenyl(lower alkyl) monosubstituted or disubstituted on the aromatic portion thereof with a halo, hydroxy, lower alkoxy, lower alkyl or trifluoromethoxy or (lower cycloalkyl)-(lower alkyl); R5B has the same significance as R2B in this claim and R6B has the same significance as R3B in this claim; or R3B is (CH2)tNR5BR6B wherein t is 1 or 2 and R5B and R6B are as defined in this claim; or R3B is CH(R7)CH2OH wherein R7B has the same significance as R4B in this claim; or a therapeutically acceptable acid addition salt thereof.