Patent ID: 6288261
Filing Date: 2001-09-11
Classification: C07C

Abstract:
A compound of formula I: ##STR12##or a pharmaceutically acceptable salt or produrug thereof, whereinR.sup.1 is selected from the group consisting of (a) a covalent bond, (b) --O--, and (c) --S(O).sub.q -- wherein q is 0, 1, or 2;R.sup.2 is hydrogen or alkyl;R.sup.3 is selected from the group consisting of (a) --HNSO.sub.2 --, (b) --O--, (c) --S(O).sub.q --, (d) --C(.dbd.O)--, and (e) --C(.dbd.NOH)--; andn is 1, 2, or 3;Ar.sup.1 is phenyl substituted with 0, 1, or 2 substituents independently selected from the group consisting of (a) alkyl, (b) perfluoroalkyl, (c) halo, (d) haloalkyl, (e) alkoxy, (f) hydroxy, (g) hydroxyalkyl, (h) alkoxyalkyl, and (i) nitro;Y is selected from the group consisting of (a) a covalent bond, (b) --O--, (c) alkylene, (d) piperidineneyl, (e) alkenylene, (f) alkynylene, (g) --S(O).sub.q --, (h) --NHC(.dbd.O)--, and (i) --C(.dbd.O)--; andAr.sup.2 is selected from the group consisting of (a) phenyl, (b) pyridyl, (c) pyrazinyl, (d) pyridazinyl, (e) furyl, (f) thienyl, (g) isoxazolyl, (h) oxazolyl, (i) thiazolyl, and (j) isothiazolyl wherein the groups defining Ar.sup.2 are substituted with 0, 1, 2, or 3 substituents independently selected from the group consisting of (1) alkyl, (2) alkoxy, (3) alkoxyalkoxy, (4) alkyloxycarbonylalkyl, (5) alkoxyalkyl, (6) cyano, (7) cyanoalkyl, (8) halo, (9) haloalkyl, (10) hydroxy, (11) hydroxyalkyl, (12) thioalkoxy, (13) thioalkoxyalkyl, (14) phenylalkoxy, (15) phenoxy, (16) --N(R.sup.2)SO.sub.2 R.sup.2' wherein R.sup.2 is defined previously and R.sup.2' is hydrogen or alkyl, (17) --SO.sub.2 N(R.sup.2)(R.sup.2') wherein R.sup.2 and R.sup.2' are defined previously, (18) phenoxyalkyl, (19) (heterocycle)oxy, (20) (heterocycle)oxyalkyl, (21) perfluoroalkyl, (22) perfluoroalkoxy, (23) sulfinylalkyl, (24) sulfonylalkyl, (25) ##STR13##wherein X.sup.1 is selected from the group consisting of --CH.sub.2 --, --CH.sub.2 O--, and --O--, and Z.sup.1 is --C(.dbd.O)-- or --(C(R.sup.2).sub.2).sub.v --, wherein R.sup.2 is defined previously, and v is 1-3, and (26) -alkyl-NR.sup.x R.sup.y wherein R.sup.x and R.sup.y are independently selected from the group consisting of(i) alkyl,(ii) phenyl substituted with 0, 1, or 2 substituents selected from the group consisting of halo and alkoxy, and(iii) phenylalkyl wherein the phenyl group is substituted with 0, 1, or 2 substituents selected from the group consisting of halo and alkoxy.