Patent ID: 9221918
Filing Date: 2015-12-29
Classification: A61P,C07K,C12P,C12Q

Abstract:
1. A polynucleotide molecule encoding a VH domain and/or a VL domain of an antigen binding polypeptide, said VH domain comprising hypervariable loops H1, H2 and H3, and said VL domain comprising hypervariable loops L1, L2 and L3, wherein said VH domain and/or said VL domain are each fused to one or more IgG constant domains of a human antibody, wherein each of the hypervariable loops H1-H3 and L1-L3 are obtained from a conventional antibody of a Lama species by active immunization of the Lama species with the human target antigen, wherein said conventional antibody is a heterotetrameric IgG antibody composed of two identical light chains and two identical heavy chains, and wherein at least one of the hypervariable loops H1, H2, L1, L2 and L3 exhibits a predicted or actual canonical fold structure which is identical or substantially identical to a canonical fold structure of a corresponding H1, H2, L1, L2 or L3 hypervariable loop which occurs in a human antibody.