Patent ID: 8574836
Filing Date: 2013-11-05
Classification: C12Q,G01N

Abstract:
1. A method for generating an interphase chromosome profile comprising: obtaining a sample containing cells having at least one interphase chromosome for profiling; obtaining a plurality of different species specific, chromosome specific, and location specific DNA probes, wherein said DNA probes contain different specific fluorescent labels and are capable of marking a normal control chromosome of the at least one interphase chromosome for profiling at substantially equidistant locations on the normal control chromosome; hybridizing said sample with said DNA probes such that differential fluorescent major color bands are produced on the at least one interphase chromosome for profiling; comparing said differential fluorescent major color bands on the at least one interphase chromosome for profiling with differential fluorescent major color bands on the normal control chromosome by visual analysis and determining the interphase chromosome profile of the at least one interphase chromosome for profiling, wherein said differential fluorescent major color bands on said normal control chromosome are generated by hybridizing said normal control chromosome with said DNA probes and detecting the hybridization of said DNA probes to said normal chromosome using said specific fluorescent labels, and each band of said differential major color bands on said normal control chromosome are spaced at substantially the same distance.