Patent ID: 6734337
Filing Date: 2004-05-11
Classification: A01K,C12N,G01N

Abstract:
A method of screening for an inhibitor of acetyl-CoA carboxylase 2 isoform activity, comprising the steps of:administering a potential inhibitor to one or more wild type mouse; and screening said one or more mouse for a phenotype exhibited by a transgenic mouse whose genome comprises a homozygous disruption of an endogenous ACC2 gene for the acetyl-CoA carboxylase 2 isoform of acetyl-CoA carboxylase, wherein said disruption inactivates said gene and wherein said mouse does not produce any functional acetyl-CoA carboxylase 2, selecting the inhibitor when given to a wild type mouse whose phenotype is exhibited the same as that of the transgenic mouse.