Patent ID: 9012642
Filing Date: 2015-04-21
Classification: A61K,C07D

Abstract:
1. A compound selected from the group consisting of: 2-(1-benzyl-4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(4-fluorobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(2-methoxyethyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-isobutyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, (S)-2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(3,4-difluorobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-1-(2-(piperidin-1-yl)ethyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-1-(2-(piperidin-1-yl)ethyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-1((2-methylthiazol-4-yl)methyl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-(2((2-hydroxy-4-methylphenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-1-(1-phenylethyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(1-benzyl-3-bromo-4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(1-benzyl-4-(4-chlorophenyl)-3,6-dimethyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-((4-fluorophenyl)sulfonyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-1-((1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(1-benzyl-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(1-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(1-(4-boronobenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(tert-butoxy)-2-(1-(4-carbamoylbenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-7-oxo-4-(p-tolyl)-1-(4-((trifluoromethyl)thio)benzyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, (S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-7-oxo-1-(thiophen-2-ylmethyl)-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-fluorophenethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-1-(4-(methylsulfonyl)benzyl)-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(3,4-difluorobenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-methoxybenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-chloro-3-fluorobenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-7-oxo-4-(p-tolyl)-1-(3,4,5-trifluorobenzyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(1-(benzo[d][1,3]dioxol-5-ylmethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(tert-butoxy)-2-(1-(4-fluorophenyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-4-(4-fluorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid, 2-(tert-butoxy)-2-(1,6-dimethyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, (S)(M)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-(pyridin-2-ylmethyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(2-methoxyethyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-chlorobenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(3-fluorobenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-(4-(trifluoromethyl)benzyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-1-(4-nitrobenzyl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(2,5-difluorobenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-(thiazol-4-ylmethyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(cyclohexylmethyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid, tert-Butoxy-[2-methyl-4-(5-methyl-chroman-6-yl)-1-oxo-1,2,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-c]pyridin-3-yl]-acetic acid, 2-(tert-butoxy)-2-(9-(4-fluorobenzyl)-2-methyl-1-oxo-4-(p-tolyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-butoxy)-2-(2,9-dimethyl-1-oxo-4-(p-tolyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-butoxy)-2-(5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3′,4′:4,5]pyrrolo[2,3-c]pyridin-8-yl)acetic acid, 2-(tert-butoxy)-2-(9-(4-fluorobenzyl)-2-methyl-1-oxo-4-(p-tolyl)-2,5,6,7,8,9-hexahydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-butoxy)-2-(2,9-dimethyl-1-oxo-4-(p-tolyl)-2,5,6,7,8,9-hexahydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-butoxy)-2-(9-(4-methoxybenzyl)-2-methyl-1-oxo-4-(p-tolyl)-2,5,6,7,8,9-hexahydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-butoxy)-2-(9-(4-methoxybenzyl)-2-methyl-4-(5-methylchroman-6-yl)-1-oxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,4-b]indol-3-yl)acetic acid, 2-(tert-Butoxy)-2-(4-(3,4-dimethylphenyl)-1-(4-methoxybenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[3,4-c]pyridin-5-yl)acetic, 2-(tert-Butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridin-5-yl)acetic acid, 2-(tert-Butoxy)-2-(1-(4-methoxybenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[3,4-c]pyridin-5-yl)acetic acid yl)acetic, 2-(tert-Butoxy)-2-(6-methyl-4-(5-methylchroman-6-yl)-7-oxo-1-(pyridin-2-ylmethyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridin-5-yl)acetic acid, 2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[3,4-c]pyridin-5-yl)acetic acid, and pharmaceutically acceptable salts thereof.