Patent ID: 8954283
Filing Date: 2015-02-10
Classification: A61P,C12Q,G16B

Abstract:
1. A method of identifying a human subject having an aggressive form of multiple myeloma, comprising the steps of: obtaining a bone marrow sample from the subject; binding a probe to a chromosome in cells of said subject sample; binding the probe to the chromosome in cells of a control sample; detecting via fluorescent in situ hybridization a signal from the probe upon binding to a locus of said chromosome in the subject sample and a signal from the probe upon binding to the locus of said chromosome in the control sample; and determining, from the detected signals, an amplification of CKS1B gene on chromosome 1q21, or a deletion of AHCYL1 gene on chromosome 1p13, wherein amplification of the 1q21 gene or deletion of the 1p13 gene in the subject sample compared to the control sample indicates the human subject has the aggressive form of multiple myeloma.