Patent ID: 8809520
Filing Date: 2014-08-19
Classification: A61P,C07F,C07H

Abstract:
1. A process for preparing a compound represented by the general formula (II): wherein: X B is selected from the group consisting of adeninyl, thyminyl, uracilyl, cytosinyl and guaninyl, R R R R n is an integer representing the number of methylene groups between X or a pharmaceutically acceptable salt thereof, the process comprising the step of coupling a nucleobase B selected from the group consisting of adenine, thymine, uracil, cytosine and guanine, in the presence of a Lewis acid catalyst, with a precursor represented by the general formula wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 14 , and n are as defined in formula (II) and wherein R 9 is an O-acyl group.