Patent ID: 6248888
Filing Date: 2001-06-19
Classification: A61P,C07D

Abstract:
A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate which comprises reacting by heating 2-chloro-4-amino-6,7-dimethoxyquinazoline and 1-(2-tetrahydrofuroyl)piperazine in a polar organic reaction solution, wherein said polar organic reaction solution comprises a polar organic solvent and a minimum amount of added water effective to produce said 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofiuroyl)piperazine hydrochloride dihydrate by precipitation.