Patent ID: 6734205
Filing Date: 2004-05-11
Classification: A61P,C07D,C07F,C07H

Abstract:
A compound represented by the formula (1): wherein E is a single bond; R is a substituted or unsubstituted indole; wherein the group represented by â€”C(O)NHC(NH)NH2 in the formula (1) is attached to 2-position thereof; A is a single bond or a substituted or unsubstituted lower alkylene group (one or more of the â€”CH2â€” groups of said lower alkylene group may be replaced by one or more groups, which may be the same or different and are selected from the group consisting of a group represented by the formula: â€”Oâ€”, â€”Sâ€”, â€”N(R1)â€” or â€”C(&boxH;O)â€”, a benzene ring and a cycloalkane ring (one or more of the â€”CH2â€” groups in said cycloalkane ring may be replaced by one or more groups, which may be the same or different and are represented by the formula: â€”Oâ€”, â€”Sâ€”, â€”N(R2)â€” or â€”C(&boxH;O)â€”) and any two adjacent atoms of said lower alkylene group may form a double bond or a triple bond); G is a single bond or a group represented by the formula: â€”Oâ€” or â€”N(R11)â€”; Y is a group represented by the formula: â€”SO3H, or â€”PO3H2, provided that G is a single bond when Y is a group represented by the formula: â€”PO3H2; R1, R11 and R2 are independently a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted cycloalkenyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted heterocyclic group, or a substituted or unsubstituted acyl group; or a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or prodrug.