Patent ID: 8012487
Filing Date: 2011-09-06
Classification: A61K,C07K

Abstract:
1. A synthetic polypeptide comprising amino acid sequences of at least one immunogenic epitope cluster (IEC) of at least two different human autoantigens related to multiple sclerosis (MS) selected from the group consisting of myelin-associated glycoprotein (MAG), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), myelin-oligodendrocytic basic protein (MOBP), oligodendrocyte-specific protein (OSP) and proteolipid protein (PLP), and wherein said IEC's are altered from their native sequence and are selected from the group consisting of the MOG-AL peptides of SEQ ID NOs: 48-53 and 232-233; the MBP-AL peptides of SEQ ID NOs: 54-61; the OSP-AL peptides of SEQ ID NOs: 62-69; the MOBP-AL peptides of SEQ ID NOs: 70-73; and the PLP-AL peptides of SEQ ID NOs: 74-86.