Patent ID: 6121240
Filing Date: 2000-09-19
Classification: A61K,A61P,C07K,Y02A

Abstract:
A compound of the formula: ##STR18## where R.sub.10 is ##STR19## or a capping group, where X is NR.sub.12, CR.sub.12 R.sub.15, O, S, SR.sub.12, or SR.sub.12 R.sub.15 ; R.sub.1, R.sub.9, R.sub.11, R.sub.12 R.sub.15 are each independently H, lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, aryl-alkenyl, aryl-alkynyl, aryl-cycloalkyl, unsubstituted or substituted with 1-3 halo, OH, NH.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylarino, lower alkylthio, CN or NO.sub.2 ;R.sub.16 is ##STR20## H, lower alkyl, cycloalkyl, or lower alkenyl; R.sub.2 is aryl or aralkyl, unsubstituted or substituted with 1-3 halo, OH, NH.sub.2, CN, NO.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl;R.sub.3 and R.sub.5 are each independently H or lower alkyl;R.sub.4 is ##STR21## where R.sub.13 is H, lower alkyl, phenyl or benzyl, and R.sub.14 is H, aryl, aralkyl, or ##STR22## where R.sub.6 and R.sub.7 are each independently H, OH, NH.sub.2, CN, NO.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl, and n and m are each independently an integer from 1 to 3 inclusive;and pharmaceutically acceptable acid addition salts thereof.