Patent ID: 6252131
Filing Date: 2001-06-26
Classification: A01K,C07K,C12N

Abstract:
A transgenic mouse whose genome comprises its endogenous 5-HT.sub.3 gene encoding the 5HT.sub.3 recetor and a transgene, wherein said transgene comprises a murine 5-HT.sub.3 transgene operably linked to a rat CAM kinsas II.mu. promoter, wherein said 5-HT.sub.3 transgene encodes the 5-HT.sub.3 receptor, and wherein said mouse express said endogenous 5-HT.sub.3 gene and the transgene, wherein the mouse is characterized by at least one characteristic selected from the group consisting of decreased craving for alcohol and decreased aggressiveness relative to non-transgenic mice of the parental strain.