Patent ID: 8470963
Filing Date: 2013-06-25
Classification: A61K,A61P,C07K

Abstract:
1. A synthetic bifunctional non-antibody compound comprising one or more effector moieties and two or more binder moieties, wherein the effector moieties are operably linked to the binder moieties via a linker, the effector moieties are ligands to at least one pathogen pattern recognition receptor (PRR) and the binder moieties are peptides or peptidomimetics that bind to a marker of a tumor cell, the binder comprising any of the following peptide sequences: SEQ ID NO 2; SEQ ID NO 3; Dhb-pLDIK; Dhb-pLDI; SEQ ID NO 4; SEQ ID NO 5; SEQ ID NO 6; cyclo(RGDfK); RGDfK; SEQ ID NO 7; SEQ ID NO 8; SEQ ID NO 9; SEQ ID NO 10; SEQ ID NO 11; SEQ ID NO 12; SEQ ID NO 13; SEQ ID NO 14; SEQ ID NO 15; DUP-1; SEQ ID NO 16; SEQ ID NO 17; cyclo(SRESPHP); SEQ ID-NO 18; SEQ ID NO 19; SEQ ID NO 20; SEQ ID NO 21; SEQ ID NO 22; SEQ ID NO 23; cyclo(CVGNDNSSC); SEQ ID NO 24; SEQ ID NO 25; SEQ ID NO 26; SEQ ID NO 27; SEQ ID NO 28; SEQ ID NO 29; SEQ ID NO 30; SEQ ID NO 31; SEQ ID NO 32; SEQ ID NO 33; SEQ ID NO 34; SEQ ID NO 35; SEQ ID NO 36; SEQ ID NO 37; MXXP, wherein X denotes any amino acid.