Patent ID: 6558913
Filing Date: 2003-05-06
Classification: C07K,C12Q,G01N

Abstract:
A method for determining whether a test person is homozygotic or heterozygotic for a mutation in Factor V and/or Factor Va or Factor VIII and/or Factor VIIIa comprising carrying out a method for determining whether a defect is present in response to APC, comprising adding APTT reagent and CaCl2 in an amount of more than 25 mM to a sample to be tested and further carrying out determination of a value for a parameter known to be useful for diagnosis of the defect, and comparing the value obtained with a value obtained in the same manner for a sample from a normal individual or from an individual known to be homozygotic or heterozygotic, thereby establishing whether the test person is homozygotic or heterozygotic for a mutation in Factor V and/or Factor Va or Factor VIII and/or Factor VIIIa.