Patent ID: 8501970
Filing Date: 2013-08-06
Classification: A61P,C07D

Abstract:
1. A method of introducing a nucleophilic aromatic moiety onto an unsubstituted C-4 carbon of a compound having a flavan-3-ol structure, comprising the steps of (a) converting the hydroxy group of the compound having the flavan-3-ol structure to an oxo group to form a flavan-3-one of that compound; (b) contacting the flavan-3-one of that compound with a compound containing the nucleophilic aromatic moiety in the presence of an oxidising agent; (c) allowing a carbon to carbon bond to form between the C-4 carbon of the flavan-3-one compound and a carbon of the nucleophilic aromatic moiety; and (d) reducing the flavan-3-one moiety to obtain the corresponding flavan-3-ol compound which is substituted by the nucleophilic moiety on the C-4 carbon.