Patent ID: 8586087
Filing Date: 2013-11-19
Classification: A61K,C08G

Abstract:
1. An amphiphilic pentablock copolymer that is temperature- and pH-sensitive and has superior gel strength, comprising: (a) a hydrophilic triblock copolymer that is temperature-sensitive and that is a copolymer of a poly(ethylene glycol)-based compound (PEG) and a biodegradable polymer that is one or more polymer selected from the group consisting of polylactide (PLA), polyglycolide (PGA), polycaprolactone (PCL), poly(caprolactone-lactide) random copolymer (PCLA), poly(caprolactone-glycolide) random copolymer (PCGA), poly(lactide-glycolide) random copolymer (PLGA), and mixtures thereof; coupled with (b) a polyurethane-based oligomer (PU) that is pH sensitive and that comprises a diisocyanate compound polymerized with a diol compound, wherein the diisocyanate compound is represented by a Formula as follows: wherein the diol compound has a tertiary amine on a main chain thereof, is one or more compound selected from the group consisting of 1,3-bis{1-(2-hydroxyethyl)-4-pyridyl}propane and 1,4-bis(2-hydroxyethyl)piperazine.