Patent ID: 8252804
Filing Date: 2012-08-28
Classification: A61K,A61P,C07D

Abstract:
1. A compound of Formula I: wherein R R A is NR′, wherein R′ is either a H or an alkyl group having from 1 to 6 carbon atoms; wherein the bond at position 5-6 may either be a single or a double bond; wherein the five membered ring has a side chain attached at positions 5, 6 or 7, and optionally includes wherein the carbon atoms at positions 5 and 6, independently, have attached thereto either (a) two hydrogen atoms if the bond between carbon atoms 5 and 6 is a single bond or one hydrogen atom if the bond between carbon atoms 5 and 6 is a double bond, or (b) an alkyl group having from one to six carbon atoms and a hydrogen atom if the bond between carbon atoms at positions 5 and 6 is a single bond or an alkyl group having from one to six carbon atoms if the bond between carbon atoms 5 and 6 is a double bond, and combinations thereof, and R X is either a heterocycloalkyl-carbonyl-L-glutamate group, a heterocycloaryl-carbonyl-L -glutamate group, or a hydrogen (H), and wherein X is a hydrogen then R wherein R y is an integer ranging from zero up to and including 6; z is an integer ranging from zero up to and including seven, wherein the sum total of integers y and z is equal to or less than seven when the side chain attachment is at position 5, and wherein when the side chain attachment is at position 6 or 7 then (i) the sum total of integers y and z is five, six, or seven when X=H, (ii) the sum total of integers y and z is equal to zero when R wherein said side chain of Formula I has one or more double bonds consisting of E-isomers and Z-isomers, wherein the double bonds are formed when R