Patent ID: 6500822
Filing Date: 2002-12-31
Classification: A61P,C07D

Abstract:
A compound Formula I wherein:R1, and R2 are independently in each occurrence hydrogen, halogen, (C1-6)-alkyl, â€”ORâ€², â€”SRâ€², â€”NRâ€²Râ€³, â€”SORâ€², â€”SO2Râ€², â€”COORâ€², â€”OCORâ€², â€”OCONRâ€²Râ€³, â€”OSO2Râ€², â€”OSO2NRâ€²Râ€³; â€”NRâ€²SO2Râ€³, â€”NRâ€²CORâ€³, â€”SO2NRâ€²Râ€³, â€”SO2 (CH2)1-3CONRâ€²Râ€³, â€”CONRâ€²Râ€³, cyano, haloalkyl, or nitro; wherein Râ€² and Râ€³ are independently in each occurrence hydrogen, (C1-6)-alkyl, substituted lower alkyl, aryl, heterocyclyl, heteroaryl, aryl-(C1-3)-alkyl, heteroaryl-(C1-3)-alkyl, heterocyclyl-(C1-3)- alkyl, cycloalkylalkyl, cycloalkyl, or Râ€² and Râ€³ together with the nitrogen they are attached may also form a 5- to 7-membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O)0-2; R3 is independently in each occurrence (C1-6) alkyl, (C1-6) alkenyl, (C1-6) alkynyl, or cycloalkyl; or Y is Nâ€”R4 and X and Z are CH2, or Z is Nâ€”R4 and X and Y are CH2; R4 is hydrogen, (C1-6)-alkyl, haloalkyl, aryl(C1-6)alkyl, heteroaryl(C1-6)alkyl, â€”(C1-6)â€”CRâ€²Râ€²Râ€², â€”COORâ€², â€”SO2Râ€², â€”C(O)Râ€², â€”SO2(CH2)0-3NRâ€²Râ€³, â€”CONRâ€²Râ€³, or â€”PO(ORâ€²)2, wherein Râ€² and Râ€³ are as defined above; substituted lower alkyl means a lower alkyl having one to three substituents selected from the group consisting of hydroxyl, alkoxy, amino, amido, carboxyl, acyl, halogen, cyano, nitro and thiol; heterocyclyl means a monovalent saturated cyclic radical, consisting of one to two rings, of three to eight atoms per ring, incorporating one or two ring heteroatoms (chosen from N,O or S(O)0-2, and which can optionally be substituted with one or two substituents selected from the group consisting of hydroxyl, oxo, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminofarbonyl, arylaminocarbonyl, alkylcarbonylamino, or arylcarbonylamino; heteroaryl means a monovalent aromatic cyclic radical having one to three rings, of four to eight atoms per ring, incorporating one or two heteroatoms (chosen from nitrogen, oxygen, or sulfur) within the ring which can optionally be substituted with one or two substituents selected from the group consisting of hydroxy, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonlamino and arylcarbonylamino; cycloalkyl means a monovalent saturated carbocyclic radical consisting of one or two rings, of three to eight carbons per ring, which can optionally be substituted with one or two substituents selected from the group consisting of hydroxy, cyano, lower alkyl, lower alkoxy, lower haloalkoxy, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; p is an integer from 1 to 3 inclusive; m is 2; n is an integer from 1 to 6 inclusive; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof.