Patent ID: 9211264
Filing Date: 2015-12-15
Classification: A61K,A61P

Abstract:
1. A pharmaceutical composition of (i) spheroid particles comprising: (a) 63.64 weight percent of (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide maleate; (b) 27.27 weight percent of microcrystalline cellulose; and (c) 9.1 weight percent of a polysorbate, said spheroid particles comprising 85 weight percent of the total composition; (ii) a sub-coating applied to said spheroid particles comprising 1.2 weight percent gain of hydroxypropylmethylcellulose and (iii) 16.9 weight percent gain of Acryl-Eze MP as an enteric coating applied to said sub-coating, said coating components (ii) and (iii) comprising 15.3 weight gain of the total composition.