Patent ID: 8410176
Filing Date: 2013-04-02
Classification: C07B,C07C,C07F

Abstract:
1. A process for the preparation of a compound of formula (A): or stereoisomers, pharmaceutically acceptable salts, or combination thereof, comprising steps (a), (b1), (c1), (d) and (e); or (a), (b2), (c2), (d) and (e): a) a Horner-Wadsworth-Emmons (HWE) reaction between 1-(3-methoxy-phenyl)-propan-1-one and a phosphonate compound of formula (I) to obtain a compound of formula (II):  wherein each R is independently alkyl or aryl which is optionally substituted with an electron withdrawing group; R′ is (i) —NR R″ is H, alkyl, aryl, heteroalkyl, heteroaryl, alkylaryl or cycloalkyl; b1) and c1): hydrogenating compound (II) to obtain the compound of formula (III):  and optionally, when R′ is other than NMe  or b2) and c2) optionally, when R′ is other than NMe  and hydrogenating compound (V) to obtain the compound of formula (IV): d) reducing the resultant compound of formula (IV) obtained in steps (c1) or (c2) to a compound of formula (VI):  and e) converting the compound of formula (VI) to a compound of formula (A):