Patent ID: 6013633
Filing Date: 2000-01-11
Classification: A61K,H01L

Abstract:
A method for suppressing an NPY-mediated physiological response in a subject comprising administering to said subject a compound having the formula: ##STR11## wherein each R1 and R2, independently, is selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C1-C18 acyl, C7-C18 aralkyl, C7-C18 alkaryl, and a dihydrotrigonellinate group;A1 is an amino acid selected from the group consisting of Trp, Gln, a tethered amino acid with an indole ring Phe, Hyp, any Trp derivative, C.alpha.Me-Trp, C.alpha.Me-Gln, Des-amino-Trp, Pyr, Bth, Nal, Tcc, Asn, Nva, Abu, Tyr, Tic-OH, Phe, Tip, and Dip;A2 is an amino acid selected from the group consisting of Arg, N-Me-Arg, C.alpha.Me-Arg Orn, Cit, hArg(R)2, where R is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, and alkylaryl, and Lys-e-NH-R, where R is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, and alkylaryl;A3 is an amino acid selected from the group consisting of N-Me-Tyr, C.alpha.Me-Tyr, Tic-OH, Tic, Dip, Trp, Phe, des-carboxylic-Tyr (tyramine), and Tyr-(R), where R is hydrogen or a lipophilic group;W is selected from the group consisting of --OH, --N-R3R4, and OR5, where R3, R4, and R5, independently, is selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C1-C12 acyl, C7-C18 aralkyl, C7-C18 alkaryl, and a pharmaceutically acceptable salt thereof; andeach dash (""-"") between two amino acids or amino acid derivatives represents either a peptide bond or a pseudopeptide bond.