Patent ID: 6184361
Filing Date: 2001-02-06
Classification: A61K,C07C

Abstract:
A complex comprising a metal and a ligand, which ligand comprises formula Ia, Ib or Ic: ##STR48##wherein at least one R' is --(A).sub.p --R.sub.2 where (A).sub.p is a linking group and R.sub.2 is a nitro-heterocyclic hypoxia localizing moiety; and wherein the other R' groups, that are not --(A).sub.p --R.sub.2, and the R groups are the same, or different and are independently selected from hydrogen, halogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, aryl, --COOR.sub.3, ##STR49##--NH.sub.2, hydroxyalkyl, alkoxyalkyl, hydroxyaryl, haloalkyl, arylalkyl, alkyl-COOR.sub.3, -alkyl-CON(R.sub.3).sub.2, -alkyl-N(R.sub.3).sub.2, -aryl-COOR.sub.3, -aryl-CON(R.sub.3).sub.2, -aryl-N(R.sub.3).sub.2, 5- or 6-membered nitrogen- or oxygen-containing heterocycle; or two R groups taken together with the one or more atoms to which they are attached form a carbocyclic or heterocyclic, saturated or unsaturated spiro or fused ring which may be substituted with R groups;R.sub.1 is hydrogen, a thiol protecting group or --(A).sub.p --R.sub.2 ;R.sub.3 is hydrogen, alkyl or aryl;m=2 to 5;p=0 to 20.