Patent ID: 7687500
Filing Date: 2010-03-30
Classification: A61P,C07D

Abstract:
1. A compound, comprising: an oxetane of Formula 1, a pharmaceutically acceptable salt, diastereomer, or mixture thereof wherein: B is a pyrimidin-1-yl or a heterocyclic isostere of a pyrimidin-1-yl, wherein the pyrimidin-1-yl or heterocyclic isostere of a pyrimidin-1-yl comprises wherein V is O or S; X is C or N; Q, T, or K are each independently hydrogen; hydroxy; halogen; cyano; azido; nitro; hydroxyamino; —COOR —CONR —OR —SR phenyl, —O(phenyl), benzyl, —O(benzyl), heterocyclic or —O(heterocyclic) group which may be unsubstituted, or mono-, di- or trisubstituted with one or more of hydroxy, amino, azido, nitro, cyano, halogen, sulfonamide, carboxyl, C —NR —NHC(O)R straight or branched C C C —CH wherein m is 1-5; wherein R hydrogen; hydroxy; amino; azido; nitro; cyano; halogen; sulfonamide; —COOR —CONR straight or branched C —C —OR —SR —O—R —NR —N(R phenyl, —O(phenyl), —O(benzyl), heterocyclic, or —O(heterocyclic) group which may be unsubstituted, or mono-, di-, or trisubstituted with one or more of hydroxy, amino, —NHC(O)R wherein R hydroxy; amino; azido; nitro; cyano; halogen; sulfonamide; —COOR —CONR —OR —SR —O—R —NR —N(R phenyl, —O(phenyl), —O(benzyl), heterocyclic, or —O(heterocyclic) group which may be unsubstituted, or mono-, di-, or trisubstituted with one or more of hydroxy, amino, —NHC(O)R wherein any two of R with the proviso that at least one of R