Patent ID: 8193316
Filing Date: 2012-06-05
Classification: A61K,A61P,C07K

Abstract:
1. A TACI-Fc fusion protein that comprises a TACI polypeptide that consists of amino acids 13 to 119 of SEQ ID NO:1, or a fragment thereof, that starts at any of amino acids 13 to 29 of SEQ ID NO:1, extends through, and terminates at, any of amino acids 105 to 119 of SEQ ID NO:1 and which binds to BLyS or APRIL or both, or a variant of said polypeptide or fragment thereof that has at least 90% sequence identity with said polypeptide or fragment and which binds to BLyS or APRIL or both; and wherein said fusion protein further comprises an Fc domain.