Patent ID: 6379396
Filing Date: 2002-04-30
Classification: A61K,A61Q

Abstract:
A composition for the oxidation dyeing of keratinous fibers wherein said composition comprises, in a medium suitable for dyeing:at least one coupler chosen from 2-chloro-6-methyl-3-aminophenol and acid addition salts thereof; and at least two oxidation bases that are different from one another chosen from at least two of the following: (a) paraphenylenediamines of formula (I) and acid addition salts thereof; â€ƒin which: R1 is chosen from a hydrogen atom, C1-C4 alkyl radicals, C1-C4 monohydroxyalkyl radicals, C2-C4 polyhydroxyalkyl radicals, (C1-C4)alkoxy(C1-C4)-alkyl radicals, and C1-C4 alkyl radicals substituted by a nitrogenous, phenyl or 4â€²-aminophenyl group; R2 is chosen from a hydrogen atom, C1-C4 alkyl radicals, C1-C4 monohydroxyalkyl radicals, C2-C4 polyhydroxyalkyl radicals, (C1-C4)alkoxy(C1-C4)-alkyl radicals and C1-C4 alkyl radicals substituted by a nitrogenous group; R3 is chosen from a hydrogen atom, C1-C4 alkyl radicals, C1-C4 monohydroxyalkyl radicals, C1-C4 hydroxyalkoxy radicals, C1-C4 acetylaminoalkoxy radicals, C1-C4 mesylaminoalkoxy radicals and C1-C4 carbamoylaminoalkoxy radicals; and R is chosen from a hydrogen atom, a halogen atom and C1-C4 alkyl radicals; with the proviso that: at least one of the R1, R2, R3 and R4 radicals is other than a hydrogen atom, when the R1, R2 and R4 radicals simultaneously represent a hydrogen atom, then the R3 radical is other than a methyl radical, when the R1, R2 and R3 radicals simultaneously represent a hydrogen atom and when the R4 radical occupies the 6 position, then R4 is other than a methyl radical, when one of the R1 and R2 radicals represents a C1-C4 alkyl radical or a C1-C4 monohydroxyalkyl radical and when the other R1 or R2 radical represents a hydrogen atom, then at least one of the R3 and R1 radicals is other than a hydrogen atom; when R1 and R2 simultaneously represent a C1-C4 monohydroxyalkyl radical, then at least one of the R3 and R4 radicals is other than a hydrogen atom; when R3 and R4 simultaneously represent a hydrogen atom, and when one of R1 and R2 is a C1-C4 alkyl radical, the other radical R1 or R2 is not a C1-C4 alkoxy (C1-C4)alkyl radical; and with the proviso that the paraphenylenediamines of formula (I) are not 2-(&bgr;-hydroxyethyl)-para-phenylenediamine, 2-(&bgr;-hydroxyethyloxy)-para-phenylenediamine, N-ethyl-N-p-hydroxyethyl-p-phenylenediamine, N,N-dimethyl-p-phenylenediamine or 2-chloro-p-phenylenediamine; (b) double bases of formula (II) and acid addition salts thereof: â€ƒin which: Z1 and Z2, which are identical or different, are chosen from a hydroxyl and â€”NH2 radicals which can be substituted by a C1-C4 alkyl radical or by a connecting arm Y; the connecting arm Y is chosen from linear and branched alkylene chains comprising from 1 to 14 carbon atoms which can be interrupted or terminated by at least one entity chosen from nitrogenous groups and heteroatoms, and which is optionally substituted by at least one radical chosen from hydroxyl and C1-C6 alkoxy radicals; R5 and R6 are chosen from a hydrogen atom, a halogen atom, C1-C4 alkyl radicals, C1-C4 monohydroxyalkyl radicals, C2-C4 polyhydroxyalkyl radicals, C1-C4 aminoalkyl radicals and a connecting arm Y; R7, R8, R9, R10, R11 and R12, which are identical or different, are chosen from a hydrogen atom, a connecting arm Y and C1-C4 alkyl radicals; with the proviso that the compounds of formula (II) only comprise a single connecting arm Y per molecule; (c) para-aminophenols of formula (III) and acid addition salts thereof: â€ƒin which: R13 is chosen from a halogen atom, C1-C4 alkyl radicals, C1-C4 monohydroxyalkyl radicals, (C1-C4)alkoxy(C1-C4)alkyl radicals, C1-C4 aminoalkyl radicals and hydroxy(C1-C4)alkylamino-(C1-C4)alkyl radicals; and R14 represents a hydrogen atom; (d) ortho-aminophenols; (e) pyridine derivatives and acid addition salts thereof chosen from 2,5-diaminopyridine, 2-(4-methoxyphenyl)amino-3-aminopyridine, 2,3-diamino-6-methoxypyridine, 2-(&bgr;-methoxyethyl)amino-3-amino-6-methoxypyridine and 3,4-diaminopyridine; (f) pyrimidine derivatives and acid addition salts thereof chosen from 2,5,6-triaminopyrimidine; (g) pyrazole derivatives and acid addition salts thereof chosen from 4,5-diamino-1-methylpyrazole, 3,4-diaminopyrazole, 4,5-diamino-1-(4â€²-chlorobenzyl)pyrazole, 4,5-diamino-1,3-dimethylpyrazole, 4,5-diamino-3-methyl-1-phenylpyrazole, 4,5-diamino-1-methyl-3-phenylpyrazole, 4-amino-1,3-dimethyl-5-hydrazinopyrazole, 1-benzyl-4,5-diamino-3-methyl-pyrazole, 4,5-diamino-3-tert-butyl-1-methylpyrazole, 4,5-diamino-1-tert-butyl-3-methylpyrazole, 4,5-diamino-1-(&bgr;-hydroxyethyl)-3-methylpyrazole, 4,5-diamino-1-ethyl-3-methylpyrazole, 4,5-diamino-1-ethyl-3-(4â€²-methoxyphenyl)pyrazole, 4,5-diamino-1-ethyl-3-(hydroxymethyl)pyrazole, 4,5-diamino-3-hydroxymethyl-1-methylpyrazole, 4,5-diamino-3-hydroxy-methyl-1-isopropylpyrazole, 4,5-diamino-3-methyl-1-isopropylpyrazole, 4-amino-5-(2â€²-aminoethyl)amino-1,3-dimethylpyrazole, 3,4,5-triamino-pyrazole, 1-methyl-3,4,5-triaminopyrazole, 3,5-diamino-1-methyl-4-(methylamino)pyrazole, and 3,5-diamino-4-(&bgr;-hydroxyethyl)amino-1-methylpyrazole; and (h) pyrazolopyrimidine derivatives of the formula (IV), and acid and base additional salts thereof, and tautomeric forms thereof, when there exists a tautomeric equilibrium: â€ƒin which: R15, R16, R17 and R18, which are identical or different, are chosen from a hydrogen atom; C1-C4 alkyl radicals; aryl radicals; C1-C4 hydroxyalkyl radicals; C2-C4 polyhydroxyalkyl radicals; (C1-C4)alkoxy(C1-C4)alkyl radicals; C1-C4 aminoalkyl radicals wherein the amine is optionally protected by an acetyl, amido or sulphonyl radical; (C1-C4)alkylamino(C1-C4)alkyl radicals; di(C1-C4)alkylamino(C1-C4)alkyl radicals wherein the dialkyls optionally form a carbonaceous ring or a heterocycle with 5 or 6 ring members; hydroxy(C1-C4)alkylamino(C1-C4)alkyl radicals; and dihydroxy(C1-C4)alkylamino(C1-C4)alkyl radicals; the X radicals, which are identical or different, are chosen from a hydrogen atom; C1-C4 alkyl radicals; aryl radicals; C1-C4 hydroxyalkyl radicals; C2-C4 polyhydroxyalkyl radicals; C1-C4 aminoalkyl radicals; (C1-C4)alkylamino(C1-C4)alkyl radicals; di(C1-C4)alkylamino(C1-C4)alkyl radicals wherein the dialkyls optionally form a carbonaceous ring or a heterocycle with 5 or 6 ring members; hydroxy(C1-C4)alkylamino(C1-C4)alkyl radicals; dihydroxy(C1-C4)alkyl-amino(C1-C4)alkyl radicals; amino radicals; (C1-C4)alkylamino radicals; di(C1-C4)alkylamino radicals; halogen atoms; carboxylic acid groups; and sulphonic acid groups; i has the value 0, 1, 2 or 3; p has the value 0or 1; q has the value 0or 1; n has the value 0 or 1; with the proviso that: the sum p+q is other than 0; when p+q is equal to 2, then n has the value 0 and the NR15R16 and R17R18, groups occupy the (2,3), (5,6), (6,7), (3,5) or (3,7) positions; when p+q is equal to 1, then n has the value 1 and the NR15R16 or NR17R18 group and the OH group occupy the (2,3), (5,6), (6,7), (3,5) or (3,7) positions; with the proviso that said composition does not simultaneously include 2-(&bgr;-hydroxyethyl)-para-phenylenediamine and tetraaminopyrimidine, either in the form of free bases or as salts thereof.