Patent ID: 8951735
Filing Date: 2015-02-10
Classification: C12Q,Y02A

Abstract:
1. A method for determining a susceptibility to breast cancer in a human individual, comprising: analyzing nucleic acid from a biological sample from the individual with respect to at least one allele of at least one polymorphic marker, selected from the group consisting of rs999737 (SEQ ID NO:6) allele C, rs2005154 (SEQ ID NO:1) allele T, rs2184380 (SEQ ID NO:2) allele G, rs2224696 (SEQ ID NO:3) allele T, rs2242503 (SEQ ID NO:4) allele C, rs12291026 (SEQ ID NO:5) allele G, rs9956546 (SEQ ID NO:7) allele A, rs11912922 (SEQ ID NO:8) allele T, rs6001954 (SEQ ID NO:9) allele G, and correlated alleles of polymorphic markers in linkage disequilibrium therewith, wherein the step of analyzing the nucleic acid sample comprises at least one nucleic acid analysis technique selected from: polymerase chain reaction, allele-specific probe hybridization, allele-specific primer extension, allele-specific amplification, nucleic acid sequencing, 5′-exonuclease digestion, molecular beacon assay, oligonucleotide ligation assay, size analysis, single-stranded conformation analysis and microarray technology, detecting the presence of the at least one allele in the nucleic acid, determining an increased susceptibility to breast cancer for the individual from the presence of the at least one allele in the nucleic acid by calculating risk measure for the individual that includes a relative risk or odds ratio of at least 1.08 attributable to the presence of the at least one allele in the nucleic acid, wherein the calculating of the risk measure is performed with an apparatus that comprises: performing a clinical screening for breast cancer selected from clinical breast examination (CBE), X-ray mammography, and contrast-enhanced magnetic resonance imaging (CE-MRI) in the individual determined to have the increased susceptibility.