Patent ID: 8753820
Filing Date: 2014-06-17
Classification: A61P,G01N

Abstract:
1. A method of identifying a compound useful in treating a disease or condition of the oral cavity, wherein said disease or condition of the oral cavity is gingivitis or periodontitis, the method comprising: obtaining a first gingival sample from a mammal suffering from said disease or condition of the oral cavity; obtaining a second gingival sample from the oral cavity of said mammal; contacting said first sample with a test compound; contacting said second sample with a positive control, wherein said positive control is a halogenated diphenylether compound which is known to down-regulate the expression of one or more biomarkers selected from the group consisting of: FAS, IL-1B, IL-8, MMP-9, DEFB4, CTSS, IL-17B, CARD10, BGN, BE, IL-12A, IL-6, LCN8, LPO and MMP-13; measuring the extent to which the expression of one or more of said biomarkers is down-regulated by said test compound; measuring the extent to which the expression of one or more of said biomarkers is down-regulated by said positive control; and comparing the extent to which the expression of one or more of said biomarkers is down-regulated by said test compound, with the extent to which the expression of one or more of said biomarkers is down-regulated by said positive control; wherein a test compound that down-regulates the expression of one or more of said biomarkers to an equal or greater extent than said positive control, is a compound useful in treating said disease or condition of the oral cavity.