Patent ID: 6159936
Filing Date: 2000-12-12
Classification: A01N,A61K,C07K,Y02A

Abstract:
A purified and isolated or recombinantly produced compound which has antimicrobial or antiviral activity and which has the formulaA.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --A.sub.18 ( 1)or a pharmaceutically acceptable salt or an N-terminal acylated or a C-terminal amidated or esterified form thereof, which is either in a linear form or in a cystine-bridged form, wherein:each of A.sub.1 and A.sub.9 is independently a basic amino acid;each of A.sub.2 and A.sub.3 is independently a small amino acid;each of A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 is independently a hydrophobic amino acid;A.sub.4 is a basic or a small amino acid;A.sub.10 is a basic or a small amino acid or is proline;A.sub.11 is a basic or a hydrophobic amino acid;A.sub.17 is not present or, if present, is a small amino acid;A.sub.18 is not present or, if present, is a basic amino acid; andeach of C.sub.6, C.sub.8, C.sub.13 and C.sub.15 is independently selected from the group consisting of cysteine, a hydrophobic amino acid, a large polar amino acid and a small amino acid.