Patent ID: 7872137
Filing Date: 2011-01-18
Classification: C07D

Abstract:
1. A process for the preparation of mivacurium chloride having a purity degree higher than 97.5%, said process comprising the following steps: (i) coupling of N-3-hydroxypropyl-1-(R)-5′-methoxylaudanosinium chloride with (E)-4-octene-1,8-dioic acid dichloride, in a suitable organic solvent, to obtain raw mivacurium chloride; (ii) extraction of raw mivacurium chloride with water; (iii) treatment of the aqueous solution of raw mivacurium chloride with a suitable nonionic polymeric adsorbent resin insoluble in water; and (iv) recovery from the aqueous solution of step iii) of mivacurium chloride having a purity degree higher than 97.5%.