Patent ID: 8808739
Filing Date: 2014-08-19
Classification: A61K,A61P

Abstract:
1. A process for the preparation of an orodispersible tablet comprising sildenafil base, the process comprising: (i) mixing respective amounts of components (a), (b), (c), and (d) together, wherein: (ii) compacting the mixture of step (i); (iii) milling the compacted mixture of step (ii); (iv) mixing together the product of step (iii), a pharmaceutically-acceptable lubricant, an additional amount of a disintegrant, and at least one further pharmaceutical excipient; and (v) compressing the mixture of step (iv) to yield an orodispersible tablet, wherein the respective amount of sildenafil base (component (a)) selected in step (i) is sufficient to comprise no less than 45% by weight of the orodispersible tablet and is insufficient to comprise more than 70% by weight of the orodispersible tablet.