Patent ID: 7947254
Filing Date: 2011-05-24
Classification: A61P,C07K,G01N

Abstract:
1. A method of detecting the presence or absence of a neuromyelitis optica (NMO)-specific autoantibody in a biological sample from an individual, comprising the steps of: contacting said biological sample with an antigenic aquaporin-4 polypeptide or fragment thereof for which a NMO-specific autoantibody has specific binding affinity; and detecting the presence or absence of binding of said antigenic aquaporin-4 polypeptide or fragment thereof to said NMO-specific autoantibody in said biological sample, wherein the presence of said binding of said antigenic aquaporin-4 polypeptide or fragment thereof to said NMO-specific autoantibody is indicative of NMO in said individual.