Patent ID: 6753428
Filing Date: 2004-06-22
Classification: C07D

Abstract:
A method for the racemization of an enantiomer, or an enantiomerically enriched mixture of a compound of formula, wherein said method comprises the steps of:contacting said enantiomer or enantiomerically enriched mixture with an alkali alkoxide in a C1-C6 primary alcohol at a selected racemization reaction temperature whereby said enantiomer or enantiomerically enriched mixture is racemized to yield a racemic mixture; and isolating the racemic mixture, wherein R1 is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; R2 is alkyl, oxaalkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; and R5, R6, R7 and R8 are independently chosen from hydrogen, alkyl, alkoxy, halogen, fluoroalkyl, nitro, dialkylamino, alkylsulfonyl, alkylsulfonamido, sulfonamidoalkyl, sulfonamidoaryl, alkylthio, carboxyalkyl, carboxamido, aminocarbonyl, aryl and heretoaryl.