Patent ID: 7189819
Filing Date: 2007-03-13
Classification: A61K,A61P,C07K

Abstract:
1. A humanized immunoglobulin which specifically binds beta amyloid peptide (Aβ), or antigen binding fragment thereof, the humanized immunoglobulin or antigen binding fragment comprising a light chain comprising (i) the variable region complementarity determining regions (CDRs) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2, and (ii) a variable framework region from a human acceptor immunoglobulin light chain, provided that at least three framework residues selected from the group consisting of L1, L2, L36 and L46 (Kabat numbering convention) are substituted with the corresponding amino acid residues from the mouse 3D6 light chain variable region sequence.