Patent ID: 6174895
Filing Date: 2001-01-16
Classification: A61P,C07D

Abstract:
A compound of the formula ##STR37##or the pharmaceutically acceptable salt thereof; whereinR.sup.1 is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.6 -C.sub.10 )aryl, (C.sub.5 -C.sub.9)heteroaryl and (C.sub.2 -C.sub.9)heterocycloalkyl wherein the alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl groups are optionally substituted by halo, hydroxy, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, amino, (C.sub.1 -C.sub.6)alkylamino, ((C.sub.1 -C.sub.6)alkyl).sub.2 amino, thio, (C.sub.1 -C.sub.6)alkylthio, cyano, carboxy, carboxy(C.sub.1 -C.sub.6)alkyl, hydroxy(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)acyl, aminosulfonyl, (C.sub.1 -C.sub.6)alkylaminosulfonyl or ((C.sub.1 -C.sub.6)alkyl).sub.2 aminosulfonyl;R.sup.2 is (C.sub.6 -C.sub.10)aryl or (C.sub.5 -C.sub.9)heteroaryl; andR.sup.3 is hydrogen, halo, hydroxy, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, amino, (C.sub.1 -C.sub.6)alkylamino, ((C.sub.1 -C.sub.6)alkyl).sub.2 amino, thio, (C.sub.1 -C.sub.6)alkylthio, carboxy, carboxy(C.sub.1 -C.sub.6)alkyl, hydroxy(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)acyl, aminosulfonyl, (C.sub.1 -C.sub.6)alkylaminosulfonyl or ((C.sub.1 -C.sub.6)alkyl).sub.2 aminosulfonyl.