Patent ID: 8420815
Filing Date: 2013-04-16
Classification: C07D

Abstract:
1. A method of preparing N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), stereoisomers, tautomers, racemics, or pharmaceutically acceptable salt thereof, wherein R1 is independently selected from H or a straight chain or branched C1-C6 Alkyl, R2 is selected from C1-C6 Alkyl, substituted or nonsubstituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups, comprising the step of: reacting a 2,3-dihydro-1H-pyrrolo[2,3-b]quinoline with a carbonyl chloride in the presence of 4-(dimethylamino)pyridine and pyridine at about room temperature, wherein the 2,3-dihydro-1H-pyrrolo[2,3-b]quinoline has the formula: wherein R1 is defined as above; and, wherein the carbonyl chloride has the formula R2COCl and R2 is defined as above.