Patent ID: 6420392
Filing Date: 2002-07-16
Classification: A61P,C07D,Y10S

Abstract:
A compound having the following structure: wherein:Ar1 is either Ar2 is and wherein:W is methyl sulfonyl; X is O, S, S(O), CR5; Y1, Y2 are independently selected from the group consisting of: (a) hydrogen; (b) lower alkyl, lower alkoxy, lower alkenyl, lower alkynyl, alkylaryl; (c) â€”AN(OM)C(O)N(R3)R4, â€”AN(R3)C(O)N(OM)R4, â€”AN(OM)C(O)R4, â€”AC(O)N(OM)R4, â€”AN(R3)C(O)N(OM)R4, â€”C(O)N(OM)R4, and â€”C(O)NHR3; wherein A is selected from the group consisting of substituted or unsubstituted lower alkyl, lower alkyl-alkoxy, -lower alkyl-heteroaromatic-lower alkyl, lower alkenyl, lower alkynyl, alkaryl or aralkyl;M is selected from hydrogen, a pharmaceutically acceptable cation, and a metabolically cleavable leaving group; R1 and R2 are independently selected from hydrogen, lower alkyl, C3-8 cycloalkyl, halo lower alkyl, halo, â€”COOH; R3 and R4 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkyl where one or more carbon atoms are replaced by S, N, or O, substituted or unsubstituted cycloalkyl of from 3 to 8 carbon atoms, where one or more carbons are replaced by S, N, or O, alkenyl, alkynyl, aryl, aralkyl, alkaryl, C1-6alkoxy-C1-10alkyl, C1-6alkylthio-C1-10alkyl, C1-6hydroxy-C1-6alkyl, C1-6carbonyl-C1-6alkyl, C1-6amino-C1-6alkyl; R5 is selected from the group consisting of: (a) hydrogen; (b) lower alkyl lower alkenyl, lower alkynyl, alkaryl; (c) â€”AN(OM)C(O)N(R3)R4, â€”AN(R)C(O)N(OM)R4, â€”AN(OM)C(O)R4, â€”AC(O)N(OM)R4, â€”AS(O)nR3, â€”AS(O)nCH2C(O)R3, â€”AS(O)nCH2CH(OH)R3, â€”AC(O)NHR3; wherein each n is independently 0, 1 or 2; A is selected from the group consisting of substituted or unsubstituted lower alkyl, lower alkyl-alkoxy, lower alkenyl, lower alkynyl, alkaryl and aralkyl; M is selected from hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable leaving group.