Patent ID: 8623606
Filing Date: 2014-01-07
Classification: G01N

Abstract:
1. A method of identifying a compound capable of forming a weak bond with a target domain of a G-protein coupled receptor comprising the steps of: (a) providing a receptor comprising said target domain and a first group linked to said target domain, wherein said target domain comprises the transmembrane or juxtamembrane domain of said G-protein coupled receptor, and wherein said first group comprises: (b) bringing into contact said receptor of (a) with a test molecule comprising a second group and said compound linked to each other, wherein said first group binds said second group, wherein said second group comprises a component selected from the group consisting of (c) determining, subsequent to the binding of said first group to said second group, whether said compound forms a weak bond to said target domain, and wherein said compound is a peptide, peptidomimetic or small organic molecule, thereby identifying a compound capable of forming a weak bond with a target domain of a G-protein coupled receptor.