Patent ID: 8535672
Filing Date: 2013-09-17
Classification: C07K

Abstract:
1. An isolated and purified peptide, consisting of: (a) a peptide consisting of an amino acid sequence that is a dimer interface of human CD28, said amino acid sequence being amino acid residues 10-15 or 116-121 of SEQ ID NO:22; (b) a peptide having a total of one or two substitutions from a peptide of (a); (c) a peptide of (a) or (b) that is extended at the N-terminus and/or the C-terminus by up to three amino acids present in corresponding positions of the amino acid sequence of the corresponding naturally occurring T-cell costimulatory pathway member; (d) a peptide of (a), (b) or (c) that is extended at the N-terminus and/or the C-terminus (e) a dimer or multimer of a peptide of (a), (b), (c) or (d).