Patent ID: 7332517
Filing Date: 2008-02-19
Classification: A61P,C07D

Abstract:
1. A method of treating a disorder selected from the group consisting of acromegaly, hypophyseal adenomas, endocrine gastroenteropancreatic tumors bleeding in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound of the formula in racemic or enantiomeric form, R1 is selected from the group consisting of (C Z1 is selected from the group consisting of H, (C Z2 is selected from the group consisting of amino, (C NH—C—(O)—O—(CH R2 is selected from the group consisting of H, (C R3 is H or(CH Z3 is selected from the group consisting of (C bis-arylalkyl or Y1 is O, S, NH or is absent; R4 is (CH Z4 is selected from the group consisting of amino, (C and N (R6)(R7), R6 and R7 taken togetber with the nitrogen atom which they carry form together a heterocycle of 5 to 7 ring members; R5 is selected from the group consisting of H, —(CH Z5 is unsubstituted or substituted member selected from the group consisting of —(C it being understood that the above substitutes of Z5 are selected from the group consisting of Cl, F, Br, I, CF 3 , NO 2 , OH, NH 2 , CN, N 3 , —OCF 3 , (C 1 -C 12 ) alkyl, (C 1 -C 12 ) alkoxy, —(CH 2 ) p -phenyl-(X 1 ) q , —NH—CO—(C 1 -C 6 ) alkyl, —NH—C(O)O—(C 1 -C 6 ) alkyl, —S—(C 1 -C 6 ) alkyl, —S-phenyl-(X1) q , —O—(CH 2 ) p -phenyl-(X1) q , —(CH 2 ) p —C(O)—O—(C 1 -C 6 ) alkyl, —(CH 2 ) p —C(O)—(C 1 -C 6 ) alkyl, —O—(CH 2 ) p —NH 2 , —O—(CH 2 ) p —NH—(C 1 -C 6 ) alkyl, —O—(CH 2 ) p —N-di((C 1 -C 6 ) alkyl) and (C 0 -C 12 ) alkyl-(X1) q ; X1, each time that it occurs, is independently selected from the group consisting of H, Cl, F, Br, I, CF p each time that it occurs is independently an integer from 0 to 6; q each time that it occurs is independently an integer from 1 to 5; X is O or S; n in the chemical structure is 0; n in Z3 is 0; and m is 1, 2 or 3; or a pharmaceutically acceptable salt of said compound sufficient to treat said disorder.