Patent ID: 6310206
Filing Date: 2001-10-30
Classification: C07C

Abstract:
A process for preparing a N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamide of the formula (I) ##STR17##whereinR represents in each case unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl,comprising the steps of:a) reacting a 2-amino-4,5-difluoro-benzonitrile of the formula (II) ##STR18##with a sulphonyl halide of the formula (III)X--SO.sub.2 --R (III)whereinR is as defined above andX represents halogenin the presence of an acid acceptor and in the presence of a diluent at a temperature between 0.degree. C. and 150.degree. C.; andb) reacting a N-(2-cyano-4,5-difluoro-phenyl)sulphonamide of the formula (IV) obtained in step a) ##STR19##whereinR is as defined above with ammonia in the presence of a diluent at a temperature between 100.degree. C. and 200.degree. C.