Patent ID: 6861434
Filing Date: 2005-03-01
Classification: A61P,C07D

Abstract:
1. A compound of formula I wherein R Z is defined by NR  wherein Y is hydrogen, hydroxy, cycloalkyl of 3 to 15 carbon atoms or phenyl, substituted phenyl, phenoxy, substituted phenoxy, naphthyl, substituted naphthyl, naphthyloxy, substituted naphthyloxy, heteroaryl, substituted heteroaryl, heteroaryloxy or substituted heteroaryloxy, wherein the heteroaryl or the heteroaryl group of heteroaryloxy is selected from thiophene, furan, pyridine, indole, chroman, coumarin, carbostyril, and quinoline; R n is an integer from 0 to 6; R R R Q is C═O, CHOH, or (CH m is an integer from 0 to 4; Ar is phenyl or indole, each optionally substituted; or R R R R R R 9 , R 10 and R 11 are, independently hydrogen, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof.