Patent ID: 7169795
Filing Date: 2007-01-30
Classification: A61P,C07D

Abstract:
1. A compound of formula Ia–If: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein; the central lactam ring is substituted with 0–2 R G is a group of formula IIa or IIb: ring D, including the two atoms of ring E to which it is attached, is a 5–6 membered ring consisting of: carbon atoms and 0–2 heteroatoms selected from the group consisting of N, O, and S(O) ring D is substituted with 0–2 R and there are 0–3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1–3 R; alternatively, ring D is absent, and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1–3 R; alternatively, ring D is absent, ring E is selected from phenyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1 R and with a 5–6 membered ring consisting of: carbon atoms and 0–4 heteroatoms selected from the group consisting of N, O, and S(O) R is selected from H, C alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; G G B is selected from —CN, C R R R R R R alternatively, NR R R R R R R alternatively, NR R R R R R R R R R R alternatively, R R n, at each occurrence, is selected from 0, 1, 2, and 3; p, at each occurrence, is selected from 0, 1, and 2; r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5, and 6; and t, at each occurrence, is selected from 0, 1, 2, and 3.