Patent ID: 9126942
Filing Date: 2015-09-08
Classification: A61K,A61P,C07D

Abstract:
1. A method of treating a condition in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula (1): or a tautomer, stereoisomer, N-oxide, or a pharmacologically acceptable salt of any of the foregoing, wherein: R R R R R R R R R R R R wherein: an asterisk (*) marks the bond to the S-atom, n is 0 or 1,  is chosen from an aryl and heteroaryl group, X, Y and Z are independently chosen from C, N, O and S, with the proviso that bonds in the ring with X, Y, and Z are single or double bonds, any X, Y, or Z that is C or N is substituted with H-atoms only, and R and R′ are independently chosen from hydrogen, halogen, alkyl(C with the proviso that the compounds of formula (1) are not: wherein the condition is chosen from Huntington's chorea, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, and type-2 diabetes.