Patent ID: 7884212
Filing Date: 2011-02-08
Classification: A61P,C07D,Y02P

Abstract:
1. A process for the preparation of candesartan cilexetil of formula (I) which comprises deprotection of the triphenylmethane (trityl) of (+/−)-1-[[cyclohexyloxy) carbonyl]oxy]-ethyl-2-ethoxy-1-[[2′-(N-triphenyl-methyltetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (trityl candesartan cilexetil) in an organic solvent and in the presence of a Lewis acid selected from the group consisting of boron trifluoride, aluminum trihalide and zinc dihalide, adding a second solvent and heating the reaction mixture, isolation of the obtained candesartan cilexetil of formula (I).