Patent ID: 6713604
Filing Date: 2004-03-30
Classification: A61K,A61P,C07K

Abstract:
A cyclic disulfide peptide of from 6 to about 8 amino acid residues that inhibits the binding of the integrin &agr;4&bgr;1 to VCAM-1 or fibronectin, the peptide having (a) an N-terminal Cys-amine group; and (b) a C-terminal Cys-carboxylic acid or Cys-amide group; said peptide comprising the contiguous amino acid residue sequence Xaa1-Xaa2-Asp-Xaa3 (SEQ ID NO:15), where Xaa1 is Trp, Xaa2 is Leu, and Xaa3 is Val.