Patent ID: 6124299
Filing Date: 2000-09-26
Classification: A61K,A61P,C07D

Abstract:
A method for treating a bone-related disorder involving bone resorption, the method comprising administering to a subject suffering from such disorder an effective amount of an anti-resorptive compound of formula I: ##STR12## wherein A is a member independently selected from group consisting of: ##STR13## B is a member independently selected from the group consisting of aryl, substituted aryl, carbocyclic ring, substituted carbocyclic ring, heterocyclic ring, substituted heterocyclic ring, and combinations thereof, said combinations being fused or covalently linked and said substituents being selected from the group consisting of halogen, haloalkyl, hydroxy, aryloxy, benzyloxy, alkoxy, haloalkoxy, amino, monoalkylamino, dialkylamino, acyloxy, acyl, alkyl and aryl;R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen and alkyl groups having from 1 to 6 carbon atoms, or taken together form a ring selected from the group consisting of saturated or unsaturated five-member rings, saturated or unsaturated six-member rings and saturated or unsaturated seven-member rings;Y.sup.1 and Y.sup.2 are each independently a bond or a divalent radical selected from the group consisting of --CH2--, --NHC(O)--, --NRC(O)--, --NHC(S)--, --NRC(S)--, --NHC(.dbd.NH)--, --OC(O)--, --C(O)--, or --C(S)--, in which R is a lower alkyl group of from one to six carbon atoms; andn is an integer of from zero to four.