Patent ID: 6193994
Filing Date: 2001-02-27
Classification: A61K,A61P,Y10S

Abstract:
A locally administrable, biodegradable and sustained-release delivery system for treatment of periodontitis comprising:A) microspheres releasing therapeutically active substances for treating periodontitis which comprises:1) active substance in an amount of more than 20 weight % of the microsphere,2) biodegradable polymer selected from the group consisting of polylactic acid and poly(lactic-co-glycolic) acid whose weight average molecular weight is in the range of 4,000 to 50,000; andB) bivalent metal ion complex of polysaccharides selected from the group consisting of pectin, carrageenan, gellan gum, sodium alginate and chitosan,wherein the release of the active substance is determined by said microspheres and is not affected by polysaccharide which is used as a supporter or a binder of the microspheres and has a property of disintegrating slowly in accordance with substituting the complexed bivalent metal ion with monovalent metal ion abundant in body fluid.