Patent ID: 9150831
Filing Date: 2015-10-06
Classification: A61P,C07K,C12N

Abstract:
1. A method of producing a population of conditionally immortalized hematopoietic stem cells, comprising: a) introducing into a plurality of hematopoietic stem cells: so as to produce at least one conditionally immortalized hematopoietic stem cell; b) culturing the plurality of hematopoietic stem cells in media comprising at least one of: IL-3, IL-6, stem cell factor, thrombopoietin, Flt3 ligand, or a combination thereof such that a population of conditionally immortalized hematopoietic stem cells is produced, and wherein the first polypeptide, the second polypeptide, or both the first and second polypeptides comprise a TAT sequence.