Patent ID: 6113899
Filing Date: 2000-09-05
Classification: A61K,A61P,C07K

Abstract:
A method for suppressing cellular growth including the step of administration of an antibody selected from the group consisting of:(a) an antibody raised against recombinant cpn10 which has the amino acid sequence GSMAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEK SQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLP EYGGTKVVLDDKDYFLFRDGDILGKYVD (SEQ ID NO:21);(b) an antibody raised against a peptide Ac-AGQAFRKFLPLC (SEQ ID NO:13); AGQAFRKFLPLC (SEQ ID NO:26); EKSQGKVLQATC SEQ ID NO:14); and(c) an antibody raised against the following peptides(i) AGQAFRKFLPL (SEQ ID NO:1)(ii) Ac-AGQAFRKFLPI (SEQ ID NO:2)(iii) EKSQGKVLQAT (SEQ ID NO:3)and any one of peptides i, ii and iii modified by a single amino acid deletion, addition or substitution, wherein the antibody is capable of suppressing cellular growth.