Patent ID: 6987128
Filing Date: 2006-01-17
Classification: A61K,A61P,A61Q,C07K

Abstract:
1. A compound chosen from compounds of formula (I): wherein: Y is chosen from O and S, R wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH (iii) radicals chosen from —OR; —NH wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH R optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH R wherein: optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH optionally substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR; —O—COR; —SH; —SR; —S—COR; —NH wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radical containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH X is a radical chosen from —OH, —OR wherein R wherein R and R′, which may be identical or different, are each chosen from linear, branched and cyclic, saturated and unsaturated hydrocarbon-based radicals containing from 1 to 6 carbon atoms, which are optionally substituted with at least one halogen, the said radicals R and R′ optionally forming, together with N in the —NRR′, a 5- or 6-membered carbon-based ring which may further comprise at least one hetero atom chosen from O, N and S in the ring, and/or which may be substituted with 1 to 5 groups, which may be identical or different, chosen from —OH; —OR″; —O—COR″; —SH; —SR″; —S—COR″; —NH the said radicals R the mineral acid and organic acid salts thereof, and the optical isomers thereof, in isolated form and as a racemic mixture, with the exception of the following compounds: N-acetylglycyl-N-(benzyl)-DL-valylglycine tert-butyl ester; N-acetylglycyl-N-(2-nitrobenzyl)-DL-valylglycine tert-butyl ester; and N-acetylglycyl-N-(2,4-dimethyloxybenzyl)-DL-valylglycine tert-butyl ester.