Patent ID: 6114143
Filing Date: 2000-09-05
Classification: A61K,C07K

Abstract:
A monoclonal antibody produced by the hybridoma deposited with the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology and having the accession number FERM BP-4561, or a fragment thereof which has an ability to neutralize HIV having an epitope, to which said monoclonal antibody binds, defined by a sequence of six amino acids selected from the group consisting of Xaa-Gly-Pro-Gly-Arg-Ala (SEQ ID NO: 59) wherein Xaa is Ala, Ile, Leu, Met, Asn, Pro, Gln, Ser, Thr, Val, or Tyr; Ile-Gly-Pro-Gly-Arg-Xaa (SEQ ID NO: 60), wherein Xaa is Ala, Cys, Asp, Glu, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; Val-Gly-Pro-Gly-Arg-Thr (SEQ ID NO: 61); Val-Gly-Pro-Gly-Arg-Ser (SEQ ID NO: 62); and Ile-Gly-Pro-Ala-Arg-Ala (SEQ ID NO: 63) within the principle neutralization domain (PND) in the third variable region (V3) of glycoprotein antigen having a molecular weight of about 1.2.times.10.sup.5 daltons (gp120) on a human immunodeficiency virus (HIV) external envelope.