Patent ID: 6770658
Filing Date: 2004-08-03
Classification: A61K,A61P,C07D,C07F

Abstract:
A compound of the formula wherein,each of the carbons at positions 3, 4, 5, 6, 7, 9, 10, 11, 12, 13, 15, 16, 17, 18, and 19, as well as the nitrogen at position 1, is independently substituted at each occurrence with H, â€”W or â€”R7(W)n, wherein W is selected from â€”NH2, â€”CONH2, â€”COOH, â€”CN, â€”CHO, â€”OCHO, â€”X, â€”OH, â€”NO2, â€”SH, â€”COX, â€”NHR8, â€”NR8R8, â€”CONHR8, â€”CONR8R8, â€”COOR8, â€”COR8, â€”OCOR8, â€”OR8, â€”BH2, â€”BHR8, â€”BR8R8, â€”BO2H2, â€”BO2R8R8, â€”PH2, â€”PHR8, â€”PR8R8, â€”POR8, â€”PO2R8, â€”PO3R8, â€”SR8; â€”SOR8, â€”SO2R8, â€”SONH2, â€”SONHR8, â€”SONR8R8, â€”SO2NH2, â€”SO2NHR8 and â€”SO2NR8R8; R7 is a C1-C30 hydrocarbyl, halocarbyl or hydrohalocarbyl group wherein n of the hydrogen or halogen atoms of R7 are substituted by an equal number of W groups independently selected at each location; R8 is a C1-C30 hydrocarbyl, halocarbyl or hydrohalocarbyl group; n is selected from 0, 1, 2, 3, 4 and 5; and X is selected from â€”Br, â€”Cl, â€”F, and â€”I; or a pharmaceutically acceptable salt or solvate thereof, or as a single stereoisomer or a mixture thereof.