Patent ID: 6294569
Filing Date: 2001-09-25
Classification: A61P,C07D,Y02P

Abstract:
A compound of the following formula: ##STR34##and the salts thereof, whereinA is hydrogen, halo, hydroxy, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo C.sub.1 -C.sub.6 alkoxy, oxo, OY wherein Y is a hydroxy protecting group, or absent;the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent;Ar.sup.1 is phenyl optionally substituted by one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy, CF.sub.3, carboxy-C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alkoxy-carbonyl-C.sub.1 -C.sub.4 alkoxy;Ar.sup.2 is phenyl, being optionally substituted by one or more substituents selected from halo, hydroxy, amino, nitro, carboxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylamino, di C.sub.1 -C.sub.4 alkylamino, halo C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkylthio and sulfonyl methyl;R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or OY wherein Y is a hydroxy protecting group; and--Ar.sup.2 --C(.dbd.O)--N(R.sup.2)-- is a phthalimide group and R.sup.3 is C.sub.1 -C.sub.7 alkyl.