Patent ID: 6207698
Filing Date: 2001-03-27
Classification: A61P,C07C,C07D

Abstract:
A pharmaceutical composition comprising a compound of formula I: ##STR627##wherein R.sup.1 is optionally substituted lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl;R.sup.2 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl;R.sup.3 is optionally substituted heteroarylene;R.sup.4 is a bond, --(CH.sub.2).sub.m --, --CH.dbd.CH--, --C.tbd.C--, --CO--, --CO--NH--, --N.dbd.N--, --N(R.sup.A)--, --NH--CO--NH--, --NH--CO--, --O--, --S--, --SO.sub.2 --NH--, --SO.sub.2 --NH--N.dbd.CH--, or tetrazol-diyl;R.sup.5 is optionally substituted lower alkyl, optionally substituted C.sub.3 -C.sub.8 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or an optionally substituted non-aromatic heterocyclic group;R.sup.A is hydrogen or lower alkyl;Y is --NHOH or --OH; andm is 1 or 2;provided R.sup.2 is hydrogen when Y is --NHOH andR.sup.5 is not lower alkyl when R.sup.4 is --CO--NH-- or --NH--CO--NH--,its optically active substance, pharmaceutically acceptable salt, or hydrate thereof and a pharmaceutically acceptable carrier.