Patent ID: 7161008
Filing Date: 2007-01-09
Classification: C07D

Abstract:
1. A process for preparing a compound of formula (III) or its diastereoisomer wherein R R R and Y* provided that R comprising reacting compounds of formulae (IV), (V), (VI) and (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the present claim, and HY* is the optically active, organic Brønsted acid, without a solvent or in one or more suitable solvents, (i) simultaneously in a direct Mannich reaction, or (ii) sequentially wherein initially the compounds of formulae (IV) and (V) are reacted to give an imine of formula (X) or an aminal of formula (XI), either of which is optionally isolated, and then reacting the compound of formula (X) or (XI) with the compounds of formula (VI) and (VII).