Patent ID: 7122682
Filing Date: 2006-10-17
Classification: A61P,C07D

Abstract:
1. A process for the manufacture of a compound of formula (22′) wherein R 2′ is hydrogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl or C 2 –C 4 alkynyl, optionally substituted by one or more halogen, said process comprising the ammonolysis of the corresponding compound of formula (6′) wherein R 1′ is C 1 –C 6 alkyl and R 2′ is hydrogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl or C 2 –C 4 alkynyl, optionally substituted by one or more halogen, in the presence of water.