Patent ID: 7025991
Filing Date: 2006-04-11
Classification: A61K,A61P

Abstract:
1. A method for preparing a nanoparticle formulation for administering one or more physiologically effective substances to the central nervous system comprising; a) providing nanoparticles consisting essentially of a polymeric material comprising one or more monomeric or oligomeric precursors polymerized in the presence of one or more stablilizers, and loaded with one or more physiologically effective substances, wherein the stabilizers are selected from the group consisting of polysorbate 85, dextran 12,000 and mixtures thereof; and optionally b) loading an effective amount of one or more physiologically effective substances to be delivered to the central nervous system of the patient into or onto the nanoparticles or both; and optionally c) providing the nanoparticles in a medium allowing the transport of the nanoparticles to the central nervous system of a patient.