Patent ID: 6077845
Filing Date: 2000-06-20
Classification: A61P,C07D

Abstract:
An acridin compound corresponding to formula I: ##STR11## wherein R.sup.1 denotes A, andR.sup.2 denotes H or OR.sup.12, or R.sup.2 and R.sup.3 together form a double bond,R.sup.3 denotes H, or R.sup.3 and R.sup.2 together form a double bond,R.sup.4 denotes CH.sub.2 NR.sup.14 R.sup.15 ;R.sup.5 denotes H or C.sub.1-6 alkyl;R.sup.6 denotes H or C.sub.1-6 alkyl;R.sup.7 denotes H;R.sup.8 denotes H;orR.sup.3 denotes A, andR.sup.1 denotes H or R.sup.1 and R.sup.4 form a double bond together;R.sup.2 denotes H;R.sup.4 denotes H or OR.sup.12, or R.sup.4 and R.sup.1 form a double bond together or R.sup.4 and R.sup.5 form a double bond together;R.sup.5 denotes H, or R.sup.5 and R.sup.4 form a double bond together;R.sup.6 denotes CH.sub.2 NR.sup.14 R.sup.15 ;R.sup.7 denotes H;R.sup.8 denotes H;orR.sup.5 denotes A, andR.sup.1 denotes H;R.sup.2 denotes H;R.sup.3 denotes H, or R.sup.3 and R.sup.6 form a double bond together;R.sup.4 denotes H;R.sup.6 denotes H or OR.sup.12, or R.sup.6 and R.sup.3 form a double bond together, or R.sup.6 and R.sup.7 form a double bond together;R.sup.7 denotes H, or R.sup.7 and R.sup.6 form a double bond together;R.sup.8 denotes CH.sub.2 NR.sup.14 R.sup.15 ;andA denotes ##STR12## R.sup.9 and R.sup.10 are identical or different from each other and denote H, OH, C.sub.1-6 alkoxy, Cl, F, CF.sub.3, CN, COOH, CONR.sup.17 R.sup.18 or COOR.sup.16 ;R.sup.11 denotes H, OH, C.sub.1-6 alkoxy, O--C.sub.3-7 cycloalkyl, O-aryl or O-heterocyclyl;R.sup.12 denotes H, C.sub.1-6 alkyl, aryl or COR.sup.13R.sup.13 denotes C.sub.1-6 alkyl or aryl,R.sup.14, R.sup.15 are identical or different from each other and denote C.sub.1-6 alkyl, aryl or C.sub.3-7 -cycloalkyl;R.sup.16 denotes C.sub.1-6 alkyl or aryl,R.sup.17, R.sup.18 are identical or different from each other and denote C.sub.1-6 alkyl or aryl; andX represents N and Y represents CH, or X represents CH and Y represents N,or a pharmaceutically acceptable salt thereof.