Patent ID: 6452037
Filing Date: 2002-09-17
Classification: A61P,B82Y,C07C,Y10S

Abstract:
A compound of the following formula: whereinp and each q, independently, is an integer of 0-20; each a is an integer of 1-8; each b is 0 or 1; each c is an integer of 1-20, provided that when b is 0, c is 1, each n is 1 or 2; m is an integer of 1-20; F1 and each F2, indepedently, is a fullerene; each of S and T, independently, is â€”OH, â€”NH2, â€”NHR, or â€”SH, wherein R being C1-30 alkyl; each A, independently, is an oligoaniline, wherein each nitrogen atom is optionally substituted with â€”Z, â€”CH2â€”COâ€”OH, â€”CH2â€”COâ€”Oâ€”Z, â€”CH2â€”COâ€”Sâ€”Z, â€”CH2â€”COâ€”NH2, or â€”CH2â€”COâ€”NHâ€”Z; each benzene ring is optionally substituted with â€”Oâ€”Z, â€”Sâ€”Z, â€”NHâ€”Z; Z being â€”Eâ€”D, wherein E is â€”Râ€”, â€”Râ€”Arâ€”, â€”Arâ€”Râ€”, or â€”Arâ€”; and D is â€”OH, â€”SH, â€”NH2, â€”NHOH, â€”SO3H, â€”OSO3H, â€”CO2H, â€”CONH2, â€”CHâ€”(NH2)â€”CO2H, â€”P(OH)3, â€”PO(OH)2, â€”Oâ€”PO(OH)2, â€”Oâ€”PO(OH)â€”Oâ€”PO(OH)2, â€”Oâ€”PO(Oâˆ’)â€”Oâ€”CH2CH2NH3+, -glycoside, â€”OCH3, â€”OCH2(CHOH)4â€”CH2OH, â€”OCH2(CHOH)2â€”CH2OH, â€”C6H3(OH)2, â€”NH3+, â€”N30 H2Rb, â€”N+HRbRc, or â€”N+RbRcRd, R being C1-30 alkyl; each of Rb, Rc, and Rd, independently, being C1-20 alkyl; and Ar being aryl; each K, independently, is â€”H3â€”[N(X)â€”C6H4]1-3â€”NH2, â€”[N(X)â€”C6H4]1-3â€”NHâ€”C(&boxH;S)â€”SH, â€”[N(X)â€”C6H4]1-3â€”N&boxH;CHâ€”Arâ€”SH, â€”[N(X)â€”C6H4]1-3â€”NHâ€”COâ€”Arâ€”SH, wherein X is â€”H, â€”Z, â€”CH2â€”COâ€”OH, â€”CH2â€”COâ€”Oâ€”Z, â€”CH2â€”COâ€”Sâ€”Z, â€”CH2â€”COâ€”NH2, â€”CH2â€”COâ€”NHâ€”Z; and Ar is aryl; each G, independently, is â€”Oâ€”Bâ€”Râ€”Oâ€”, â€”NHâ€”Bâ€”Râ€”NHâ€”, â€”Oâ€”Bâ€”Râ€”NHâ€”, â€”NHâ€”Bâ€”Râ€”Oâ€”, â€”Oâ€”Bâ€”Râ€”Sâ€”, â€”NHâ€”Bâ€”Râ€”Sâ€”, wherein R is C1-30alkyl; B, independently, is â€”R1â€”Oâ€”[Si(CH3)2â€”Oâ€”]1-100, C1-2000 alkyl, C6-40 aryl, C7-60 alkylaryl, C7-60 arylalkyl, (C1-30 alkyl ether)1-100(C6-40 aryl ether)1-100, (C7-60 alkylaryl ether)1-100, (C7-60 alalkyl ether)1-100, (C1-30 alkyl tioether)1-100, (C6-40 aryl thioether)1-100, (C7-60 alkylaryl thioether)1-100, (C7-60 arylalkyl thioether)1-100, (C2-50 alkyl ester)1-100, (C7-60 aryl ester)1-100, (CK-70 alkylaryl ester)1-100, (C8-70 arylalkyl ester)1-100, â€”R1â€”COâ€”Oâ€”(C1-30 alkyl ether)1-100, â€”R1â€”COâ€”Oâ€”(C6-40 aryl ether)1-100, â€”R1â€”COâ€”Oâ€”(C7-60 alkylaryl ether)1-100, â€”R1â€”COâ€”Oâ€”(C7-60 arylalkyl ether)1-100, (C4-50 alkyl urethane)1-100, (C14-60 aryl urethane)1-100, (C10-80 alkylaryl urethane)1-100, (C10-80 arylalkyl urethane)1-100, (C5-50 alkyl urea)1-100, (C14-60 aryl urea)1-100, (C10-80 alkylaryl urea)1-100, (C10-80 arylalkyl urea)1-100, C2-50 alkyl amide)1-100, (C7-60 aryl amide)1-100, (C8-70 alkylaryl amide)1-100, (C8-70 arylalkyl amide)1-100, (C3-30 alkyl anhydride)1-100, (C8-50 aryl anhydride)1-100, (C9-60 alkylaryl anhydride)1-100, (C9-60 arylalkyl anhydride)1-100, (C2-30 alkyl carbonate)1-100, (C7-50 aryl carbonate)1-100, (C8-60 alkylaryl carbonate)1-100, (C8-60 arylalkyl carbonate)1-100, â€”R1â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C1-30 alkyl ether, C6-40 aryl ether, C7-60 alkylaryl ether, or C7-60 arylalkyl ether)1-100, â€”R1â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C2-50 alkyl ester, C7-60 aryl ester, C8-70 alkylaryl ester, or C8-70 arylalkyl ester)1-100, â€”R1â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C1-30 alkyl ether, C6-40 aryl ether, C7-60 alkylaryl ether, or C7-60 arylalkyl ether)1-100, â€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”, â€”R1â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C2-50 alkyl ester, C7-60 aryl ester, C8-70 alkylaryl ester, or C8-70 arylalkyl ester)1-100â€”R3â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”, â€”R1â€”NHâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C1-30 alkyl ether, C6-40 aryl ether, C7-60 alkylaryl ether, or C7-60 arylalkyl ether)1-100, â€”R1â€”NHâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”(C2-50 alkyl ester, C7-60 aryl ester, C8-70 alkylaryl ester, or C8-70 arylalkyl ester),1-100, â€”R1â€”NHâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C1-30 alkyl ether, C6-40 aryl ether, C760 alkylaryl ether, or C7-60 arylalkyl ether)1-100â€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”, â€”R1â€”NHâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”(C2-50 allyl ester, C7-60aryl ester, C8-70alkylaryl ester, or C8-70 arylalkyl ester),1-100â€”R3Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”Oâ€”, â€”R1â€”Oâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”NHâ€”(C2-50 alkyl amide, C7-60 aryl amide, C8-70 alkylaryl amide, or C8-70 arylalkyl amide)1-100, or â€”R1â€”NHâ€”COâ€”NHâ€”(R2 or Arâ€”R2â€”Ar)â€”NHâ€”COâ€”NHâ€”(C2-50 alkyl amide, C7-60 aryl amide, C8-70 alkylaryl amide, or C8-70 arylalkyl amide)1-100; wherein each of R1, R2and R3, independently, is C1-30 alkyl; and Ar is aryl.