Patent ID: 6060455
Filing Date: 2000-05-09
Classification: A61K,C07C,C12N

Abstract:
A compound of the formula (I) ##STR2## in which R.sub.1 is a saturated or unsaturated C(O)--C.sub.1-23 or saturated or unsaturated C.sub.1-24 chain,A is selected from A.sub.1 and A.sub.2A.sub.1 is an O--R.sub.2 group in which R.sub.2 has the meaning stated for R.sub.1 and can be the same as or different from R.sub.1,A.sub.2 is an NR.sub.3 X or an N.sup.+ R.sub.3 R.sub.4 R.sub.5 Y.sup.- residue in whichR.sub.3, R.sub.4 are independently selected from the group consisting of hydrogen, an alkyl group with 1 to 4 C atoms, a (CH.sub.2).sub.n --OH and a (CH.sub.2).sub.n --NH.sub.2 group where n=2-6, provided that R.sub.3 and R.sub.4 are not both hydrogen,R.sub.5 which can be the same as or different from R.sub.3 and R.sub.4, is hydrogen, an alkyl group with 1 to 4 C atoms, a (CH.sub.2).sub.n --OH, a (CH.sub.2).sub.n -halogenide or a ((CH.sub.2).sub.m NH).sub.o --(CH).sub.2).sub.n group in which m is an integer from 2 to 6 and is equal to or different from n and o wherein n is a number from 2 to 6 and o is an integer from 0 to 4,X has the meaning for R.sub.5 or has the following meaning: an amidically bound amino acid, an amidically bound peptide or polypeptide, a C(O)--CHR.sub.6 N(R.sub.7).sub.2, a C(O)--CHR.sub.6 N.sup.+ (R.sub.7).sub.3, a C(O)--CHR.sub.6 N.sup.+ (R.sub.7).sub.2 R.sub.8 or a C(O)--CHR.sub.6 NR.sub.7 R.sub.8 group, provided that if R.sub.3 X is an amidically bound amino acid, an amino acid derivative, a peptide or polypeptide, wherein,R.sub.6 is a (CH.sub.2).sub.m --NR.sub.7 R.sub.8, a (CH.sub.2).sub.m --N.sup.+ (R.sub.7).sub.3 R.sub.8 or a (CH.sub.2).sub.m --N.sup.+ (R.sub.7).sub.2 R.sub.8 residue and m is a number from 1 to 5,R.sub.7 is hydrogen or an alkyl group with 1 or 4 C atoms,R.sub.8 is a (CH.sub.2).sub.n --N(R.sub.7).sub.2 or (CH.sub.2).sub.n --N.sup.+ (R.sub.7).sub.3 group in which n is a number from 2 to 4 and R.sub.7 can have the meaning stated above andY is a pharmaceutically acceptable anion,B is selected from B.sub.1 and B.sub.2,B.sub.1 is an NH[C(O)--(CH.sub.2).sub.p --NH].sub.q --Z residue in which p is a number from 1 to 6 and q is a number from 0 to 2,Z is an amidically bound amino acid, an amidically bound peptide or polypeptide, a C(O)--CHR.sub.6 N(R.sub.7).sub.2, a C(O)--CHR.sub.6 N.sup.+ (R.sub.7).sub.3, a C(O)--CHR.sub.6 N.sup.+ (R.sub.7).sub.2 R.sub.8 or a C(O)--CHR.sub.6 NR.sub.7 R.sub.8 group wherein R.sub.6 to R.sub.8 and m have the aforementioned meanings andB.sub.2 has the meaning stated for A.sub.1 and when A is A.sub.1, B is B.sub.1 and when A is A.sub.2, B is B.sub.2.