Patent ID: 8765390
Filing Date: 2014-07-01
Classification: C12N,G01N

Abstract:
1. A method for characterizing a head and throat squamous carcinoma from a patient, the method comprising: (a) contacting a sample of said head and throat squamous carcinoma with reagents that bind CD44, reagents that bind lineage markers CD2, CD3, CD10, CD16, CD18, CD31, CD64, and CD140b, and reagents that bind involucrin, and one or both of CK5 and/or CK14, wherein said head and throat squamous carcinoma sample is CK5/14 positive and involucrin negative; (b) quantitating the number of CD44 positive, lineage marker negative cancer cells; and (c) identifying cancer stem cells as CD44 positive, lineage marker negative cancer cells of head and throat squamous carcinoma.