Patent ID: 7427637
Filing Date: 2008-09-23
Classification: A61P,C07D

Abstract:
1. A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; n is 0 or 1; r is 0 or 1; s is 0 or 1; u is 2, 3, 4 or 5; a dashed line represents an optional double bond, provided that one and only one double bond is present in the ring; X is —CH Y is O; Z is —C(═O)—, R said aryl, cycloalkyl, aralkyl and heterocyclyl is optionally substituted with one or more substituents selected from R 10 ; R said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, aralkyl and heterocyclyl is optionally substituted with one or more substituents selected from R 10 ; or R —N(R R said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, alkylene and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ; R said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 11 , or R R said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R R