Patent ID: 8716459
Filing Date: 2014-05-06
Classification: A61K,A61P,C07K

Abstract:
1. An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of: (a) a polynucleotide having sequence set forth in SEQ ID NO 23; (b) a polynucleotide encoding a polypeptide having the amino acid sequences set forth in SEQ ID NO: 24; (c) a polynucleotide encoding a polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth at amino acids 25 through 134 of SEQ ID NO:18, wherein the polypeptide comprises an amino acid substitution at position 28 of SEQ ID NO:18; (d) a polynucleotide encoding a polypeptide comprising an amino acid sequence at least 98% identical to the amino acid sequence set forth at amino acids 25 through 134 of SEQ ID NO:18, wherein the polypeptide comprises an amino acid substitution at position 28 of SEQ ID NO:18; and (e) a polynucleotide encoding a polypeptide comprising an amino acid sequence at least 99% identical to the amino acid sequence set forth at amino acids 25 through 134 of SEQ ID NO:18, wherein the polypeptide comprises an amino acid substitution at position 28 of SEQ ID NO:18.