Patent ID: 7776536
Filing Date: 2010-08-17
Classification: C12Q,G16B

Abstract:
1. A process comprising the steps of: (a) providing an array comprising a plurality of target elements bound to a solid surface, each target element comprising a target nucleic acid, which target nucleic acid is not in a cell nucleus and lacks superstructure of a condensed chromosome; (b) contacting the target elements with a first collection of genomic DNA molecules comprising a plurality of first genomic DNA molecules each of which specifically hybridizes to a different target nucleic acid under pre-selected hybridization conditions, wherein said first collection of genomic DNA molecules is labeled with a detectable label; (c) detecting the amount of binding of the first genomic DNA molecules to the target nucleic acids; (d) storing the data regarding the amount of binding detected in step (c) in a computer; (e) comparing the amount of binding detected in step (c) to the amount of binding of at least a second collection of genomic DNA molecules to the target nucleic acids; and (f) identifying an increase or decrease in chromosomal copy number between the first collection of genomic DNA molecules and at least a second collection of genomic DNA molecules based on comparison step (e).