Patent ID: 7871995
Filing Date: 2011-01-18
Classification: A61K,A61P

Abstract:
1. A drug delivery system for parenteral, or rectal administration, comprising an estrogenic component and a progestogenic component, said drug delivery system being selected from the group consisting of suppositories, systems for intravaginal delivery, injectable or implantable depot preparations, inhalers, nasal sprays and transdermal delivery systems, wherein the system contains at least 0.01 mg of the estrogenic component, wherein said estrogenic component is selected from the group consisting of substances represented by the following formula: in which formula R 1 , R 2 , R 3 , R 4 , independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; and no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method, which precursors are derivatives of the substances represented by the formula, wherein the hydrogen atom of at least one of the hydroxyl groups in said formula has been substituted by an acyl radical of a hydrocarbon carboxylic, sulfonic or sulfamic acid of 1-25 carbon atoms; tetrahydrofuranyl; tetrahydropyranal; or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue; and mixtures of one or more of the aforementioned substances and/or precursors, and wherein the system does not contain a luteinizing hormone releasing hormone (LHRH) composition or a gonadotropin hormone releasing hormone (GnRH) composition.