Patent ID: 6492389
Filing Date: 2002-12-10
Classification: A61K

Abstract:
A method of inducing apoptosis of cells in a subject, which said cells are regulated by Bcl-2, comprising administering to the subject an effective amount of an active compound of the formula III: wherein:X is selected from the group consisting of CH2; CHOCH3; NH; NCH3; O; and S; R1 is selected from the group consisting of OH; NH2; CHO; COCH3; COOH; N(C1-3 alkyl)2; NH(C1-3 alkyl); OCOCH3; OCOCH2CH3; NHCOCH3; NHNHCOCH3; NHNHCONH2; N(C1-3 alkyl)2; NH(C1-3 alkyl); R2 is selected from the group consisting of C1-3 alkyl; C1-3 alkoxy; OH; NH2; CHO; COCH3; OCOCH3; OCOCH2CH3; COOH; COOCH3;COOCH2CH3; COOCH2CH2CH3; R3 is selected from the group consisting of C1-3 alkyl; C1-3 alkoxy; CN; CH2CN; CH2NO2; CHO; COCH3; COOH; OCOCH3; OCOCH2CH3; NHCOCH3; NHNHCOCH3; NHNHCONH2; CH&boxH;CH2; CH2CH&boxH;CH2; CH2CHO; R4 is selected from the group consisting of C1-3 alkyl; C1-3 alkoxy; CN; CH2CN; CH2NO2; CHO; COCH3; COCH3; COOH; COOCH3; COOCH2CH3; COOCH2CH2CH3; OCOCH3; OCOCH2CH3; R5 is selected from the group consisting of hydrogen CH3; OCH3; OH: NH2; Br; Cl; and F; and R6, R7 and R8 are selected from the group consisting of hydrogen, CH3; CH2CH3; CF3; NH2; OH; OCH3; CN; NO2; Cl; Br; F; COOH; and COOCH3; provided, at least one member of the group R6, R7 or R8 must be Cl, Br or F when the remaining members of said group are hydrogen; or a pharmaceutically acceptable salt thereof when the compound includes at least one NH2 or COOH substituent.