Patent ID: 8278499
Filing Date: 2012-10-02
Classification: A01K,G01N

Abstract:
1. A rodent showing a symptom of human nonalcoholic steatohepatitis consisting of lipid droplet deposition, inflammatory cell infiltration and fibrosis in the hepatic tissue, the rodent being obtained by a method comprising: a first step of transplanting human hepatocytes into an immunodeficient hepatopathic rodent to produce a chimeric rodent; and a second step of transplanting human hepatocytes that are propagated in the body of the chimeric rodent into an immunodeficient hepatopathic rodent of the same species as the immunodeficient hepatopathic rodent described above, the second step being conducted once or a plurality of times, wherein the resultant immunodeficient hepatopathic rodent has a blood human albumin level of 0.1 mg/ml or more and shows a symptom of human nonalcoholic steatohepatitis consisting of lipid droplet deposition, inflammatory cell infiltration and fibrosis in the hepatic tissue.