Patent ID: 9044531
Filing Date: 2015-06-02
Classification: A61B,A61F,A61L,A61P,D01D,D01F,D04H,Y10T

Abstract:
1. A vascular closure device comprising: a preshaped, cylindrical fibrous plug formed prior to delivery from a nonwoven fabric of at least one randomly oriented and entangled fiber, the thickness of the nonwoven fabric ranging from about 0.25 to 2 mm, the basis weight of the nonwoven fabric ranging from about 0.01 to 0.2 g/in at least one agent, in therapeutic dosage, dispersed in the fiber matrix of the at least one randomly oriented fiber, and configured for controlled elution therefrom, the at least one agent comprises an agent selected from a group consisting of anti-proliferative agents, anti-thrombogenic agents, anti-restenotic agents, anti-viral agents, anti-inflammatory agents, cytostatic agents, immunosuppressive agents, anti-calcification agents, anti-encrustation agents, statins, hormones, anti-cancer agents, anti-coagulants, anti-migratory agents, tissue growth promoting agents, heparin, and combinations thereof.