Patent ID: 7521051
Filing Date: 2009-04-21
Classification: A61K,A61P,C07K

Abstract:
1. A method of upmodulating adaptive immune response comprising: contacting a lymphocyte with an isolated anti-PD-1 antibody, wherein the antibody comprises: a VH domain or an antigen-binding fragment thereof that comprises 3 CDRs; and a VL domain or an antigen-binding fragment thereof that comprises 3 CDRs; wherein the antibody comprises at least 3 VH domain CDRs having sequences of: SEQ ID NO:23, SEQ ID NO:24 and SEQ ID NO:25; or SEQ ID NO:29, SEQ ID NO:30 and SEQ ID NO:31; or SEQ ID NO:35, SEQ ID NO:36 and SEQ ID NO:37; or at least 3 VL domain CDRs having sequences of: SEQ ID NO:26, SEQ ID NO:27 and SEQ ID NO:28; or SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34; or SEQ ID NO:38, SEQ ID NO:39 and SEQ ID NO:40.