Patent ID: 6288029
Filing Date: 2001-09-11
Classification: A61K,A61P,C07K

Abstract:
A method of reducing airway resistance in a patient suffering from a bronchial disease or condition, comprising administering a therapeutically effective dose of a NPY or PPY agonist to said patient, wherein said NPY or PPY agonist comprises:a) a template comprising a cyclized peptide 3 to 10 amino acid in length, wherein at least two residues in said cyclized peptide are joined by a naphthyl ring at the 2 and 8 position of said naphthyl ring; andb) at least one linear peptide between 12 and 37 amino acids in length covalently bound to said template, wherein said linear peptide has a C-terminal sequence selected from the group consisting of: RHYINLITRQRY, (SEQ ID NO:3); and RHYLNLVTRQRY (SEQ ID NO:4); and wherein the C-terminal tyrosine of said linear peptide is amidated.