Patent ID: 9222105
Filing Date: 2015-12-29
Classification: C07K,C12N,C12Y

Abstract:
1. A non-naturally occurring fusion protein comprising a zinc finger protein that binds to an endogenous hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene and a nuclease cleavage domain, wherein the fusion protein modifies the endogenous HPRT gene and further wherein the zinc finger protein comprises 5 or 6 zinc finger domains, each zinc finger domain comprising a recognition helix region, wherein the zinc finger protein comprises the recognition helix regions in the order shown in a single row of rows 3 to 5 or 10 to 23 of Table 1 and further wherein the zinc finger protein targets a sequence selected from the group consisting of SEQ ID NO: 41, 42 or 125-136.