Patent ID: 8216589
Filing Date: 2012-07-10
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An HBV vaccine particle comprising an entire recombinant HBV surface antigen (L-HBsAg), wherein the entire recombinant HBV surface antigen consists of L surface protein, M surface protein and S surface protein co-expressed by a recombinant expression vector comprising a base sequence of SEQ ID NO:1, wherein the L surface protein comprises a preS1 antigen, a preS2 antigen and an S antigen, the M-surface protein comprises a preS2 antigen and an S antigen and the S protein comprises an S antigen, and wherein the preS1 and preS2 antigens are located on the external surface of the particle formed by bonds between S antigens.