Patent ID: 7271266
Filing Date: 2007-09-18
Classification: A61P,C04B,C07D

Abstract:
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein; R 1 is selected from: (1) hydrogen, (2) halogen, (3) C (4) cycloheteroalkyl, (5) cycloheteroalkyl-C (6) heteroaryl, (7) aryl-C (8) heteroaryl-C (9) —OR (10) —SR (11) —O—(CR (12) —O—(CR (13) —O—(CR (14) —O—(CR (15) —O—(CR (16) —NR (17) —C(O)R (18) —CO (19) —CN, (20) —C(O)NR (21) —NR (22) —NR (23) —NR wherein the alkyl groups are optionally substituted with one to four substituents independently selected from R a , and cycloheteroalkyl, aryl and heteroaryl are optionally substituted with one to four substituents independently selected from R b ; R 2 is selected from: (1) hydrogen, (2) cyano, (3) —C(O)OR (4) —C(O)NR (5) halogen, (6) nitro, (7) trifluoromethyl, and (8) C(O)NH—NR provided that R 1 and R 2 are not both hydrogen; R 3 is selected from: (1) hydrogen, (2) C (3) cycloalkyl, and (4) trifluoromethyl, wherein alkyl, and cycloalkyl are optionally substituted with one to four substituents independently selected from R a ; R 4 , R 5 , R 6 and R 7 are each independently selected from: (1) hydrogen, (2) halogen, (3) amino, (4) carboxy, (5) C (6) (7) aryl, (8) aryl C (9) trifluoromethyl, (10) —OC(O)C (11) —OC(O)NR provided that R 6 and R 7 are not both hydrogen; each R a is independently selected from: (1) —C(O)R (2) —CO (3) —CO (4) —OC(O)R (5) —CN, (6) —C(O)NR (7) —NR (8) —OC(O)NR (9) —NR (10) —NR (11) —CR (12) —CF (13) —OCF (14) C each R b is independently selected from: (1) R (2) C (3) C (4) C (5) aryl, and (6) aryl-C wherein alkyl, alkenyl, alkynyl, and aryl are optionally substituted with one to four substituents selected from a group independently selected from R c ; each R c is independently selected from: (1) halogen, (2) amino, (3) carboxy, (4) —OR (5) —NR (6) —NO (7) halogen, (8) —S(O) (9) —SR (10) —S(O) (11) —S(O) (12) —NR (13) —O(CR (14) C (15) C (16) aryl, (12) aryl C (13) hydroxy, (14) CF (15) —OC(O)C (16) —OC(O)NR R d and R a are independently selected from: (1) hydrogen, (2) C (3) C (4) C (5) cycloalkyl, unsubstituted or substituted with one to three substituents selected from R (6) cycloalkyl-C (7) cycloheteroalkyl, unsubstituted or substituted with one to three substituents selected from R (8) cycloheteroalkyl-C (9) aryl, unsubstituted or substituted with one to three substituents selected from R (10) heteroaryl, unsubstituted or substituted with one to three substituents selected from R (11) aryl-C (12) heteroaryl-C R d and R e together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—R h , unsubstituted or substituted with one or two oxo groups; R f and R g are independently selected from (1) hydrogen, and (2) C 1-4 alkyl; each R h is independently selected from: (1) halogen, (2) amino, (3) hydroxycarbonyl, (4) C (5) C (6) aryl, (7) aryl C (8) hydroxy, (9) —CF (10) —OC(O)C (11) aryloxy, (12) C (13) —C(O)—NH—C m is selected from 1 and 2; n is selected from 1, 2, 3 and 4; p is selected from 0, 1, and 2; and and pharmaceutically acceptable salts thereof.