Patent ID: 8188117
Filing Date: 2012-05-29
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I) or of the formula (I′) wherein R1 is H, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, [(C1-C6)alkylene]0-1-(C3-C8)cycloalkyl, [(C1-C6)alkylene]0-1-(C5-C10)heterocyclyl, [(C1-C6)alkylene]0-1-(C6-C10)aryl, C(O)—(C1-C6)alkyl, C(O)(C2-C6)alkenyl, C(O)—(C2-C6)alkynyl, C(O)—[(C1-C6)alkylene]0-1-(C3-C8)cycloalkyl, C(O)—[(C1-C6)alkylene]0-1-(C5-C10)heterocyclyl, or C(O)—[(C1-C6)alkylene]0-1-(C6-C10)aryl; R2 is H, (C1-C6)alkyl, [(C1-C6)alkylene]0-1-R′, [(1-C6)alkylene]0-1-O—(C1-C6)alkyl, [(C1-C6)alkylene]0-1-O—R′, [(C1-C6)alkylene]0-1-NH2, [(C1-C6)alkylene]0-1-NH(C1-C6)alkyl, [(C1-C6)alkylene]0-1-N[(C1-C6)alkyl] R3 is H, halogen, CN, (C1-C6)alkyl, (C1-C6)alkylene-R′, OH, O—R″, NH2, NHR″, NR″R″ or NH—C(O)—R″; R4 is H, halogen, OH, CN, (C1-C6)alkyl, (C3-C8)cycloalkyl, (C1-C6)alkylene-R′ or NH—(C6-C10)aryl; R5 is H, halogen, CN, NO2, (C1-C6)alkyl, (C2-C6)alkenyl, R′, (C1-C6)alkylene-R′, (C1-C6)alkylene-(C6-C10)aryl, (C2-C6)alkenylene-(C6-C10)aryl, (C1-C6)alkylene-(C5-C10)heterocyclyl, NH2, NH—R′, NH—SO2H, NH—SO2-(C1-C6)alkyl, NH—SO2-R′, NH—C(O)—(C1-C6)alkyl, NH—C(O)—R′, C(O)N[(C1-C6)alkyl]2, C(O)OH or C(O)O—(C1-C6)alkyl; R6 is H, R′, (C1-C8)alkyl, (C1-C6)alkylene-R′, (C1-C6)alkylene-O—(C1-C6)alkyl, (C1-C6)alkylene-O—R′, (C1-C6)alkylene-CH[R′]2, (C1-C6)alkylene-C(O)—R′, (C1-C6)alkylene-C(O)NH2, (C1-C6)alkylene-C(O)NH—R′, or (C1-C6)alkylene-C(O)N[R′]2; R7 and R8 are independently of each other H, halogen, CN, NO2, (C1-C6)alkyl, O—(C1-C6)alkyl, O—[(C1-C6)alkylene]0-1-R′, (C2-C6)alkenyl, R′, (C2-C6)alkenylene-(C6-C10)aryl, (C1-C6)alkylene-R′, NH2, NH—R′, NH—SO2H, NH—SO2-(C1-C6)alkyl, NH—SO2-R′, SO2-NH2, SO2-NHR′, NH—C(O)—(C1-C6)alkyl, NH—C(O)—R′, C(O)N[(C1-C6)alkyl]2, C(O)OH or C(O)O—(C1-C6)alkyl; R9 is halogen or (C1-C6)alkyl; R′ is (C3-C8)cycloalkyl, (C5-C10)heterocyclyl or (C6-C10)aryl; R″ is (C3-C8)cycloalkyl, (C5-C10)heterocyclyl, (C6-C10)aryl, (C1-C6)alkyl, (C1-C6)alkylene-R′, (C1-C6)alkylene-O—(C1-C6)alkyl, (C1-C6)alkylene-O—R′, or (C1-C6)alkylene-NRxRy; Rx and Ry are independently of each other (C1-C6)alkyl, (C5-C10)heterocyclyl, (C6-C10)aryl, (C1-C4)alkylene-(C5-C10)heterocyclyl, (C1-C4)alkylene-(C6-C10)aryl, (C1-C4)alkylene-NH(C1-C6)alkyl, (C1-C4)alkylene-N[(C1-C6)alkyl]2, (C1-C4)alkylene-N [(C6-C10)aryl]2, or (C1-C4)alkylene-N[(C5-C10)heterocyclyl]2; n is 0, 1, 2, 3 or 4; and L is O or O—(C1-C6)alkylene; wherein in residues R4, R5, R7 and R8 one alkyl or alkylene hydrogen atom can optionally be substituted by OH, OCH3, COOH, COOCH3, NH2, NHCH3, N(CH3)2, CONH2, CONHCH3 or CON(CH3)2, or an alkyl or alkylene may be halogenated once or more; or a pharmaceutically acceptable salt thereof, stereoisomeric form thereof or physiologically functional derivative thereof, pharmaceutically acceptable salt of a stereoisomeric form thereof or physiologically functional derivative thereof, or stereoisomeric form of a physiologically functional derivative thereof.