Patent ID: 9115210
Filing Date: 2015-08-25
Classification: A61K,A61P,C07K,C12N,C12Y

Abstract:
1. A purified mutant streptokinase polypeptide having a cysteine residue substituted for at least one amino acid selected from the group consisting of: H16, A17, D62, G80, G166, S157, A181, I205, S210, D212, D213, D219, D222, D237, K238, D239, E265, K273, D290, D291, L296, D298, S322, I371, N372, K373, K374, S375, L377, E398, K399, F404, D420, L438, L443, A450, D464, D477, R489, H518, A519, D564, and G582, relative to the sequence of SEQ ID NO: 24, and wherein said mutant has biological activity as measured by a standard assay.