Patent ID: 6329566
Filing Date: 2001-12-11
Classification: A01K,A61K,A61P,C07K,C12N,C12Q,G01N

Abstract:
A method for identifying a gene involved in neurodegeneration, said method comprising the steps of:a) providing a nematode comprising an expression construct, said expression construct comprising a promoter derived from a cAMP regulatory gene selected from the group consisting of an acy-1 gene, an eat-4 gene, an unc-36 gene, and a glutamate receptor-encoding gene, said promoter operably linked to a reporter gene;b) isolating a nematode comprising a mutation on the basis that said nematode exhibits an altered level of reporter gene expression relative to an unmutated nematode comprising said expression construct; andc) identifying said gene comprising said mutation, said gene being involved in neurodegeneration.