Patent ID: 8871447
Filing Date: 2014-10-28
Classification: A61K,A61P,C07K

Abstract:
1. A composition comprising an isolated conformational epitope of a soluble amyloid aggregate which a) forms in a human or animal and b) contributes to amyloid disease; said conformational epitope comprising five or more monomers, wherein the epitope is affixed to a curved or flat support surface, wherein affixation to the support surface causes the epitope to assume and be constrained in a three-dimensional conformation, wherein the three-dimensional confirmation causes the epitope to be recognized by an antibody that binds an Aβ peptide aggregate that is not a monomer, dimer, trimer, tetramer or Aβ fibril; and wherein the support surface comprises a material selected from; gold, zinc, cadmium, tin, titanium, silver, selenium, gallium, indium, arsenic, silicon, mixtures thereof and combinations thereof.