Patent ID: 6191150
Filing Date: 2001-02-20
Classification: C07D

Abstract:
A compound of the formula ##STR143##whereR.sub.1 is ##STR144##whereA.sub.1 is alkylene, alkenylene, alkynylene, or a direct bond;A.sub.2 is O, S, SO, SO.sub.2, or a direct bond;A.sub.3 is alkyl, alkenyl, alknyl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, aryl, or hydrogen;R.sub.2 is ##STR145##whereD.sub.1 is ##STR146##or a direct bond,D.sub.2 is alkylene, alkenylene, alkynylene, or a direct bond,D.sub.3 is cycloalkylene, cycloalkenylene, heterocyclylene, arylene, hetereroarylene, or a direct bond,D.sub.4 is alkyl, aryl, heteroaryl, or hydrogen;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is ##STR147##whereE.sub.1 is alkylene, alkenylene, alkynylene, or a direct bond,E.sub.2 is S, O, SO, SO.sub.2, C(O)O, OC(O), NR.sub.7, C(O)NR.sub.7, NR.sub.7 C(O), SO.sub.2 NR.sub.7, or a direct bond, where R.sub.7 is as defined;E.sub.3 is alkylene, cycloalkylene, cycloalkenylene, arylene, heterocyclylene, heteroarylene, or a direct bond;E.sub.4 is ##STR148##E.sub.5 is lower alkyl or hydrogen;R.sub.5 is hydrogen or lower alkyl;R.sub.6 is ##STR149##whereZ.sub.1 is heteroarylene or a direct bond;Z.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, aryl, NR.sub.8 R.sub.9, OR.sub.8, or hydrogen, where R.sub.8 and R.sub.9 are as defined; andR.sub.7, R.sub.8, and R.sub.9 are, independently, hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, or heteroaryl;or a pharmaceutically acceptable salt, solvate, biohydrolyzable ester, biohydrolyzable amide, affinity reagent, or prodrug thereof.