Patent ID: 6133442
Filing Date: 2000-10-17
Classification: A61P,C07C,C07D

Abstract:
A compound of formula: ##STR6## wherein R.sup.1 is phenyl, substituted phenyl or heterocyclyl;R.sup.2 is phenyl or substituted phenyl;R.sup.3 is hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, substituted phenyl, heterocyclyl or a residue --CONR.sup.5 R.sup.6 or --NR.sup.5 COR.sup.7 ;R.sup.4 is hydrogen or lower-alkyl;R.sup.5 is hydrogen or a residue R.sup.7, andR.sup.6 is --(CH.sub.2).sub.m R.sup.7 ; orR.sup.5 and R.sup.6 together with the N atom associated with them is a heterocyclic residue;R.sup.7 is phenyl, substituted phenyl, cycloalkyl, heterocyclyl, lower-alkyl, cyano-lower-alkyl, hydroxy-lower-alkyl, di-lower-alkylamino-lower-alkyl, carboxy-lower-alkyl, lower-alkoxycarbonyl-lower-alkyl, lower-alkoxycarbonylamino-lower-alkyl or phenyl-lower-alkoxycarbonyl;R.sup.a is hydrogen, lower-alkyl or hydroxy;R.sup.b is hydrogen or lower-alkyl;Z is hydroxy, amino or a residue --OR.sup.8, --OC(O)NHR.sup.8, --OC(O)OR.sup.8, --NHC(O)NHR.sup.8 or --NHC(O)OR.sup.8 ;R.sup.8 is heterocyclyl, phenyl, substituted phenyl or lower-alkyl;A and Y each independently is oxygen or sulphur,X is nitrogen;m is 0, 1 or 2; andn is 0, 1 or 2;or a pharmaceutically usable salt thereof.