Patent ID: 7332164
Filing Date: 2008-02-19
Classification: A61K,A61P

Abstract:
1. A compound of the formula: wherein: X R R R y, p, y′ and p′ are independently zero or a positive integer; n and n′ are independently 0 or a positive integer; a and b are independently zero or a positive integer, provided that a+b is greater than or equal to 2; z is a positive integer; D wherein B is selected from the group consisting of biologically active moieties, diagnostic agents and OH; said leaving groups are selected from the group consisting of halogens, activated carbonates, carbonyl imidazole, cyclic imide thiones, isocyanates, N-hydroxysuccinimidyl, para-nitrophenol, N-hydroxyphtalimide, N-hydroxybenzotriazolyl, imidazole, and tosylates; and said terminal groups are selected from the group consisting of: wherein: Y R R Ar is a moiety which forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group; L e and f′ are independently selected positive integers; c, c′ and e′ are independently zero or a positive integer; d, f and d′ are independently zero or one; and B′ is selected from the group consisting of leaving groups, activating groups, OH, biologically active moieties and diagnostic agents wherein said leaving groups are selected from the group consisting of halogens, activated carbonates, carbonyl imidazole, cyclic imide thiones, isocyanates, N-hydroxysuccinimidyl, para-nitrophenol, N-hydroxyphtalimide, N-hydroxy-benzotriazolyl, imidazole, and tosylates provided that n and n′ are positive integers when both a and b are positive integers.