Patent ID: 6719958
Filing Date: 2004-04-13
Classification: A61K,C07C,C07D

Abstract:
A compound of formula (I):L[NH2]p[NHF]z[N[F]2]xâ€ƒâ€ƒ(I), in whichL is a polyaminic organic moiety; F is a â€”CH2â€”Tâ€”K group, representing a chelant/chelate residue, where T is a C2-C5 aliphatic chain, interrupted or not by one or more heteroatoms selected from O, N, S or by functional groups selected from carbonyl, thiocarbonyl, amide, ester, thiourea, thioamide groups, said chain being linked covalently to an atom of a residue K, K is a tetraazacyclododecyl containing group, or one of its metal chelates, or one of its salts and where the total number of the F groups is 3 to 2 m; pis a number from 0 to m âˆ’ 2,zis a number from 0 to mâˆ’ 1, andxis a number from 1 to m,â€ƒwhere m is a number from 2 to 1000, m being the total number of the primary amino groups originally present on L and where p+x+z=m, with the proviso that, when x=1, then zâ‰ 0, and in which the chelated metal ions are bi- or trivalent paramagnetic ions or radioisotopes.