Patent ID: 6166222
Filing Date: 2000-12-26
Classification: C07D

Abstract:
A process for preparing chiral 3,4-dehydroprolines of the formula I ##STR4## where R is a chiral group,R' is hydrogen or a C.sub.1 -C.sub.6 -alkyl, C.sub.2-7 -alkenyl, C.sub.7-9 -arylalkyl or tri-C.sub.1-4 -alkylsilyl radical andR"" is a protective group,which comprises reacting a pyrrolecarboxylic acid derivative of the formula II ##STR5## in ammonia with an alkali metal or alkaline earth metal and then with an aqueous salt solution or a compound of the formula IIIR'--X III,where X is a leaving group.