Patent ID: 8198487
Filing Date: 2012-06-12
Classification: A61B,C07C,C07F

Abstract:
1. A method for carrying out a lithium exchange reaction comprising mixing at least two fluids, one of the at least two fluids comprising, a compound able to react with a lithium exchange reagent in a lithium exchange reaction (1 st reactant), and another fluid comprising a lithium exchange reagent (2 nd reactant), said mixing taking place in a microreactor comprising at least one flow path for one of the at least two fluids comprising either the 1 st or 2 nd reactant, said flow path(s) comprising at least two reaction regions, each reaction region comprising an injection point for feeding the other one of the two fluids comprising either the 2 nd or 1 st reactant, a mixing zone in which the at least two fluids contact each other and a reaction zone, and wherein the microreactor optionally provides one or more additional residence time volumes or has additional residence time volumes attached, and wherein in said method one of the at least two fluids comprising either the 1 st or 2 nd reactant establishes a first flow and wherein the other one of the at least two fluids comprising either the 2 nd or 1 st reactant is injected into said first flow at least at two injection points along said flow path(s) in a way such that at each injection point less than the total amount necessary to reach completion of the lithium exchange reaction is injected.