Patent ID: 6331630
Filing Date: 2001-12-18
Classification: A61K,A61P,C07D

Abstract:
A dimeric arylisoquinoline of coupled first and second arylisoquinoline monomers selected from the group consisting of derivatives of dioncophylline D, wherein: (a) the configuration at C-1 or C-3 is instead S; one or more phenolic hydroxyl group(s) is instead an ester, sulfonate ester, or ether group; a methyl ether group is instead a phenolic hydroxyl group; one or more phenolic hydroxyl group(s) is instead an aromatic hydrogen substituent; the secondary amine site is instead an amide, sulfonamide, tertiary amine, alkyl quaternary ammonium salt or corresponding Hoffmann elimination product thereof; at least one CH.sub.3 is instead H; and/or the tetrahydroisoquinoline is instead a dihydroisoquinoline; and (b) a substituent at C-4 is azido, alkoxy, aryloxy, glycosyloxy or oxo; or any combination of the foregoing.