Patent ID: 8263103
Filing Date: 2012-09-11
Classification: A61L

Abstract:
1. A medical article comprising (a) a biodegradable polymer that produces acidic molecules upon degradation within a subject; and (b) an acid neutralizing cationic species, wherein said cationic species is a polycationic polymer, wherein said biodegradable polymer and said acid neutralizing cationic species are blended within a polymeric region in the form of a biodegradable coating that is provided over a metallic or ceramic substrate, said medical article being an implantable or insertable medical article, and wherein said medical article comprises a single therapeutic agent as the only therapeutic species, which therapeutic agent is not electrostatically bound to or entrapped within said cationic species, which therapeutic agent is selected from an uncharged therapeutic agent and a cationic therapeutic agent, and which is released from said article within said subject.