Patent ID: 6544987
Filing Date: 2003-04-08
Classification: A61P,C07D

Abstract:
A compound of formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: A is C3-C5 alkylene optionally substituted with one or more suitable substituents excluding 6-membered fused aryl groups and optionally any one of the CH2 groups of the alkylene group may be replaced by O, S, SO or SO2; B is â€ƒwhere E and G are independently Ar, H, C1-C6 straight or branched alkyl, C1-C6 straight or branched alkenyl, C1-C6 straight or branched alkyl or alkenyl that is substituted with a C5-C7 cycloalkyl, C1-C6 straight or branched alkyl or alkenyl that is substituted with a C5-C7 cycloalkenyl, or Ar substituted with C1-C6 straight or branched alkyl or alkenyl, wherein, in each case, one or two of the CH2 groups of the alkyl or alkenyl chains may be replaced by 1-2 moieties selected from the group consisting of oxygen, sulfur, SO, SO2, and â€ƒwhere J is H, C1-C6 straight or branched alkyl, or C1-C6 straight or branched alkenyl; and K is Ar or substituted 5-7 membered cycloalkyl with substituents at positions 3 and 4 which are independently selected from the group consisting of H, OH, â€”Oâ€”(CH2)m-alkyl, â€”Oâ€”(CH2)m-alkenyl and carbonyl, wherein m is 1-4; where Ar is selected from the group consisting of unsubstituted and substituted phenyl, 1-napthyl, 2-naphthyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, and monocyclic and bicyclic heterocyclic ring systems with each ring having 5 or 6 ring atoms optionally, 1-4 heteroatoms independently selected from O, N and S; wherein when substituted, the substituents are from one to three substituents independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, C1-C6 straight or branched alkyl, C2-C6 straight or branched alkenyl, Oâ€”(C1-C4 straight or branched alkyl), Oâ€”(C2-C4 straight or branched alkenyl), O-benzyl, O-phenyl, 1,2-methylenedioxy, amino, carboxyl and phenyl; and n is an integer from 0 to 4; D is C1-C6 straight or branched alkyl, C1-C6 straight or branched alkenyl, C5-C7 cycloalkyl, C5-C7 cycloalkenyl substituted with C1-C4 straight or branched alkyl or C1-C4 straight or branched alkenyl, [(C2-C4)-alkyl or (C2-C4)-alkenyl)]-Ar, or Ar excluding benzyl; and X is NR10 or O, where R10 is H, C1-C4 alkyl, C1-C4 alkenyl, or hydroxy.