Patent ID: 6514948
Filing Date: 2003-02-04
Classification: A61K,A61P

Abstract:
A method for enhancing an immune response to an antigenic substance, comprising administering intranasally a polynucleotide comprising an immunostimulatory nucleotide sequence (ISS) to a subject antigenic about one day to about seven days prior to exposure to the antigenic substance by the subject, wherein the ISS comprises the sequence 5â€²-rrcgyy-3â€² (SEQ ID NO: 1), 5â€²-rycgyy-3â€² (SEQ ID NO: 2), 5â€²-rrcgyycg-3â€² (SEQ ID NO: 3) or 5â€²-rycgyycg-3â€² (SEQ ID NO: 4), andwherein upon exposure to the antigenic substance, an immune response specific for the antigenic substance antigenic is enhanced relative to an immune response produced by administration of the substance alone.