Patent ID: 7531313
Filing Date: 2009-05-12
Classification: A61K,A61P,C07K

Abstract:
1. A method of screening for biologically active agents that modulate the binding of relaxin to LGR7 the method comprising: combining a candidate biologically active agent in vitro with (a) a human LGR7 polypeptide that specifically binds relaxin or (b) a cell comprising a nucleic acid encoding a human LGR7 polypeptide that specifically binds relaxin and comparing in the presence and absence of said agent one or more of: (i) the level of binding of relaxin to LGR7, (ii) the level of binding of relaxin to said agent, and (iii) the level of cAMP production, to thereby identify a biologically active agent that modulates the binding of relaxin to LGR7.