Patent ID: 9216152
Filing Date: 2015-12-22
Classification: A61K,A61L

Abstract:
1. An injectable microparticle composition in a kit, the kit comprising a population of microparticles, comprising: (1) a blend of immiscible polymers, (2) a blend of polymers which phase separate into identifiable domains, (3) a copolymer comprising segments which are immiscible, (4) a copolymer comprising segments which phase separate into identifiable domains, or (5) blends thereof, the polymers or copolymers containing monomers selected from the group consisting of glycolide, lactide, caprolactone, and 4-hydroxybutyrate, wherein at least one polymer or blend of polymers is selected from the group consisting of (1) a blend of poly(L-lactide) (L-PL) or poly(DL-lactide) (DL-PL) and polycaprolactone; (2) a copolymer of DL-lactide or L-lactide and caprolactone; (3) a copolymer of DL-lactide or L-lactide, glycolide, and caprolactone; and (4) a blend of L-PL or DL-PL and poly(caprolactone) admixed with poly(lactide-co-glycolide) (PLG), and a liquid vehicle for suspension of the microparticles to produce a solids content of between 10 wt % and less than 100 wt %, wherein the microparticles are injectable when suspended in a vehicle consisting of water, 0.5 wt % sodium carboxymethylcellulose, USP low viscosity grade, and 0.1 wt % polysorbate 80 and a means for injection of the suspension of the microparticles comprising a needle or other device with a lumen, the needle or device having an inner and an outer diameter, wherein (a) the ratio of the needle inner diameter to the mean particle size of the population of microparticles is from 2.0 to 4.5 when the vehicle added to the microparticles forms a suspension with a solids content from 10 wt. % to <30 wt. % or (b) the ratio of the needle inner diameter to the mean particle size of the population of microparticles is from 4.0 to 8.0 when the vehicle added to the microparticles forms a suspension with a solids content ≧30 wt. %.