Patent ID: 6635637
Filing Date: 2003-10-21
Classification: A61P,C07D

Abstract:
A compound of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof, wherein:R1 is one of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl, any of which is optionally substituted; Z is one of â€”OSO2â€”, â€”SO2Oâ€”, â€”OC(RyRz)â€”, or â€”C(RyRz)Oâ€”; Ry and Rz are each independently one of hydrogen, alkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or carboxy; R3, R4, R5 and R6 are each independently one of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamido, â€”CO2Rx, â€”CH2ORx or â€”ORx, or when present on adjacent carbon atoms, R4 and R3 may also be taken together to form one of â€”CH&boxH;CHâ€”CH&boxH;CHâ€” or â€”(CH2)qâ€”, where q is from 2 to 6, and R5 and R6 are defined as above; Rx, in each instance, is independently one of hydrogen, alkyl or cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations; Y is one of â€”Oâ€”, â€”NR10â€”, â€”Sâ€”, â€”CHR10â€” or a covalent bond; and R10, in each instance, is independently one of hydrogen, alkyl, aralkyl, aryl, hydroxy(C2-10)alkyl, amino(C2-10)alkyl, monoalkylamino(C2-10)alkyl, dialkylamino(C2-10)alkyl or carboxyalkyl; A is one of wherein:Ra, Rb and Rc are independently hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano or â€”CO2Rw, where Rw is alkyl, cycloalkyl, phenyl, benzyl, â€ƒwhere Rd and Rc are independently hydrogen, C1-6 alkyl, C2-6 alkenyl or phenyl, Rf is hydrogen, C1-6 alkyl, C2-6 alkenyl or phenyl, Rg is hydrogen, C1-6 alkyl, C2-6 alkenyl or phenyl, and Rh is aralkyl or alkyl; n and nâ€² are each from zero to 4; m is from zero to 2; mâ€² is zero or 1; and j and jâ€² are each from zero to 2; provided that n, nâ€², m, mâ€², j and jâ€² are not all zero.