Patent ID: 7696238
Filing Date: 2010-04-13
Classification: A61P,C07D

Abstract:
1. A substituted benzo[d]isoxazol-3-yl amine compound corresponding to formula I wherein R R R R R R R R R wherein the aforementioned C the aforementioned C the aforementioned heterocycloalkyl groups each comprise a 4-, 5-, 6- or 7-membered ring containing 1 or 2 heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen, and may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —CN, —OH, —SH, —C the aforementioned aryl groups each independently denote a phenyl, anthracenyl or naphthyl group, which optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —CF —NO 2 , cyclohexyl, —SF 5 , —CN, —OH, —SH, —C 1-5 -alkyl, —O—C 1-5 -alkyl, —S—C 1-5 -alkyl, —C(═O)—OH, —O(C═O)C 1-2 -alkyl, —C(═O)—OC 1-5 -alkyl, —NH 2 , —N(H)(C 1-5 -alkyl), —N(C 1-5 -alkyl)(C 1-5 -alkyl), —C(═O)NH 2 , —C(═O)N(H)(C 1-5 -alkyl), —C(═O)N(C 1-5 -alkyl)(C 1-5 -alkyl), —S(═O) 2 NH 2 , —S(═O) 2 N(H)(C 1-5 alkyl), —S(═O) 2 N(C 1-5 -alkyl)(C 1-5 -alkyl), —S(═O) 2 -phenyl, —S(═O) 2 —C 1-5 -alkyl, phenyl, phenoxy, benzyl, benzyloxy, thiophenyl (thienyl), furanyl and pyridinyl; and the aforementioned heteroaryl groups each independently denote a 5- or 6-membered aromatic ring containing 1, 2 or 3 heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen, and may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —CF or a pharmaceutically acceptable salt thereof.