Patent ID: 8754210
Filing Date: 2014-06-17
Classification: A61P,C07D

Abstract:
1. A method for preparing an oxazolidinone derivative of formula (I) or a pharmaceutically acceptable salt thereof, comprising the steps of: introducing an amino protecting group to a cyclic amidrazone of formula (V) to obtain a compound of formula (VI); reducing the nitro group of the compound of formula (VI) to obtain a compound of formula (VII); subjecting the compound of formula (VII) to a reaction with 5-chloro-N-(((S)-oxiran-2-yl)methyl)thiophene-2-carboxamide to obtain a compound of formula (VIII) having a chlorothiophene group; conducting a carbonylation reaction of the compound of formula (VIII) using a phosgene equivalent to obtain an oxazolidinone of formula (IX); and removing the amino protecting group from the amidrazone ring of the oxazolidinone of formula (IX), wherein, R′ is hydrogen, C PG is formyl, (C