Patent ID: 6565842
Filing Date: 2003-05-20
Classification: A61K,C07K,C08F,C08H,C12N

Abstract:
A chemically modified polypeptide having the formula:Pâ€”(Aâ€”C(O)â€”Y)n wherein:P is a non-denatured protein selected from the group consisting of albumin, casein, fibronectin, vitronectin, laminin, fibrinogen, hirudin, proinsulin, muramyl dipeptide, &agr;-1 antitrypsin, &agr;-2-macroglobulin, lactalbumin, and ovalbumin, A is â€”Oâ€”, â€”Sâ€”, or â€”NRâ€”, wherein R is hydrogen or lower alkyl, wherein A, in combination with a carbonyl moiety, directly links Y to P, Y is: â€”C(R)&boxH;CRâ€²2, or â€”Câ‰¡CRâ€²â€ƒwherein: R is hydrogen, lower alkyl or substituted lower alkyl, and Râ€² is hydrogen or lower alkyl, and n is at least 1, and wherein said chemically modified polypeptide is capable of homopolymerizing under conditions that are nontoxic to living cells.