Patent ID: 6235766
Filing Date: 2001-05-22
Classification: A61P,C07D

Abstract:
A compound of formula (I) ##STR34##in which:R(1) is(1) halogen;(2) hydroxyl;(3) (C.sub.1 -C.sub.4)-alkoxy;(4) (C.sub.1 -C.sub.8)-alkoxy, wherein 1 to 6 carbon atoms are replaced by the heteroatoms O, S, or NH,(5) (C.sub.1 -C.sub.4)-alkoxy, substituted by a saturated cyclic ether;(6) O-(C.sub.1 -C.sub.4)-alkenyl;(7) O-(C.sub.1 -C.sub.4)-alkylaryl; or(8) phenoxy, unsubstituted or substituted by a substituent selected from halogen, (C.sub.1 -C.sub.3)-alkyl, (C.sub.1 -C.sub.3)-alkoxy, and trifluoromethyl;R(2) is(1) CHO;R(3) is(1) (C.sub.1 -C.sub.4)-alkyl; or(2) aryl;R(4) is(1) hydrogen;(2) halogen; or(3) (C.sub.1 -C.sub.4)-alkyl;X is(1) oxygen; or(2) sulfur;Y is(1) oxygen; or(2) --NH--;R(5) is(1) hydrogen;(2) (C.sub.1 -C.sub.6)-alkyl; or(3) (C.sub.1 -C.sub.4)-alkylaryl;where R(5) can only be hydrogen if Y has the meaning mentioned under (2); andR(6) is(1) (C.sub.1 -C.sub.5)-alkyl;in any stereoisomeric form or mixture thereof in any ratio, or a physiologically acceptable salt thereof.