Patent ID: 9125880
Filing Date: 2015-09-08
Classification: A61K,A61P,C07K,G01N

Abstract:
1. A composition comprising a detergent and a non-glycosylated interferon-beta conjugate prepared by selectively coupling one or more synthetic water-soluble polymers to the amino-terminal amino acid of a non-glycosylated interferon-beta, wherein said one or more synthetic water-soluble polymers is selected from the group consisting of one or more polyethylene glycols and one or more polyethylene oxides, wherein said amino-terminal amino acid is located remotely from the receptor-binding domain(s) of said interferon-beta, and wherein said conjugate has increased in vitro biological potency as compared to said non-glycosylated interferon-beta that has not been coupled with one or more synthetic water-soluble polymers when assayed under the same conditions.