Patent ID: 6426400
Filing Date: 2002-07-30
Classification: A61K

Abstract:
A compound for labeling a ligand which binds to a cell surface antigen, said compound comprising a molecule of formula (I): wherein â€”NHâ€” is an amino end and â€ƒis a carboxyl end of the molecule; wherein AA is an amino acid residue; wherein n is an integer having a value of at least 3; wherein R1 is H or an amino protecting group; wherein R2 is H or a carboxyl protecting group, with the proviso that R1&boxH;R2&boxH;H is an unsatisfied condition with said molecule; wherein R1 or R2 is H; wherein at least three amino acid residues are positively charged; wherein at least one amino acid residue is a D-amino acid; wherein the molecule does not comprise two or more contiguous L-amino acids; wherein at least one amino acid residue is coupled to a label; and wherein said molecule is sufficient to be coupled to a ligand which specifically binds to a cell surface antigen at only one of said amino end or said carboxyl end.