Patent ID: 6437167
Filing Date: 2002-08-20
Classification: B01D,B01J,C07B,C07C,C07K,G01N

Abstract:
A chiral selector of formula (I)wherein:X=NR1â€”CHR2R3 R1 is selected from: H, branched or linear alkyl having 1 to 6 carbon atoms, R2 is selected from: the group consisting of H, branched or linear alkyl having 1 to 6 carbon atoms, aryl or arylalkyl, containing or not containing a heteroatom, being said aryl or arylalkyl substituted or unsubstituted with â€”OH or â€”CH2CONH2, R3 is selected from: branched or linear alkyl having 1 to 6 carbon atoms, (CH2)pâ€”COOH, (CH2)pâ€”CONH2, (CH2)pâ€”CONHR4, (CH2)pâ€”NHCOR4, (CH2)pâ€”CON(R4R5), CONHCH(R4)CONHR4, (CH2)pâ€”NHCOCH(R4)NHCOR4, C6H4â€”CH2â€”NHCOCH(R4)NHCOR4 and CH2NH(CH2)pâ€”NHCOCH(R4)NHCOR4, where p is an integer from 0 to 4, R4 and R5 are independently selected from the group consisting of: (a) linear or cyclic alkyl having from 1 to 6 carbon atoms, (b) aryl, and (c) a spacer group of formula â€”(CH2)nâ€”Siâ€”(OR6)3 where n ranges from 1 and 10 and R6 is an alkyl with 1 to 4 carbon atoms; said groups (a) and (b) being substituted or unsubstituted with alkyl with 1 to 4 carbon atoms, aryl, cycloalkyl having 5-6 carbon atoms, NO2 and OCH3, or: (i) R1 forms together with R2, with the carbon atom bound to R2 and with the nitrogen, a 5-6 membered ring, or (ii) R2 forms with R3 and with the carbon atom bound to R2 and R3 a 5-6 membered ring substituted by â€”NHCOR4, or by â€”NHCOCH(R4)NHCOR4, where R4 is selected from the group consisting of: (a) linear or cyclic alkyl having from 1 to 6 carbon atoms, (b) aryl, and (c) a spacer group of formula â€”(CH2)nâ€”Siâ€”(OR)3 where n ranges from 1 and 10 and R6 is an alkyl with 1 to 4 carbon atoms, said groups (a) and (b) being unsubstituted or substituted from the group consisting of 1 to 4 carbon atom alkyl, aryl, cycloalkyl having 5-6 carbon atoms, NO2 and OCH3, Y and Z independently of each other are selected from the group consisting of chloro, X group where X is defined above, a spacer group of formula â€”A(CH2)nâ€”Siâ€”(OR6)3 where A represents NH or O, and n and R6 are defined above; with the proviso that said formula (I) contains: (a) one to three X groups containing at least one chiral atom, and (b) only one spacer group as above defined.