Patent ID: 7442788
Filing Date: 2008-10-28
Classification: A61P,C07H,C12N

Abstract:
1. An antisense molecule comprising: a nucleic acid selected from the group consisting of DNA, RNA, and derivatives thereof; and a molecule coupled to said nucleic acid and selected from the group consisting of monomeric or polymeric mono-, oligo-, or polyamino acids-nucleosides represented by the general formula (3): wherein each X is the same or different and represents a pyrimidine or purine base or a derivative thereof; each Y and Y′ is the same or different and represents at least one amino acid or amino acid derivative selected from the group consisting of serine, threonine, ornithine, aspartic acid, glutamic acid, lysine, arginine, cysteine, methionine, δ-hydroxylysine, N-aminoethylglycine, N-aminoethylserine, N-aminoethyllysine, N-aminoethylomithine, N-aminoethylaspartic acid, N-aminoethylglutamic acid, homoglutamic acid, β-thiocarbonylaspartic acid, γ-thiocarbonylglutamic acid, and δ-thiocarbonylhomoglutamic acid, A represents a single bond or a carbonyl or thiocarbonyl group, 1 is an integer of 0 to 5, and n is an integer of 1 to 100.