Patent ID: 6419918
Filing Date: 2002-07-16
Classification: A61K,C07K

Abstract:
A preparation of isolated and purified human pluripotent colony stimulating factor having the ability to induce the acquisition of increased receptors for chemotactic peptide and increased glycoconjugate synthesis,wherein the human pluripotent colony stimulating factor has the following characteristics: a) a molecular weight of about 19,600 daltons under reducing and non-reducing conditions as determined by SDS-PAGE; b) a molecular weight of about 32,000 daltons as determined by gel filtration; c) an isoelectric point of about 5.5; d) the ability to induce differentiation of the leukemia cell line WEHI-3B (D+); and e) the ability to stimulate growth or early hematopoietic progenitor cells.