Patent ID: 8415378
Filing Date: 2013-04-09
Classification: A61P,C07D

Abstract:
1. A compound, or a pharmaceutically acceptable salt thereof, selected from: 5-((2S,4S)-2-Benzylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-Benzylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Benzylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-Benzylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Isobutylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-Isobutylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-Isobutylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Phenethylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-Phenethylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-Phenethylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(4-tert-Butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-tert-Butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-Neopentylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Neopentylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(2-Methyl-2-phenylpropyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Methyl-2-phenylpropyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(Cyclohexylmethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(Cyclohexylmethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(Cyclohexylmethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,4-Difluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,4-difluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Chlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(4-Chlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-chlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-(Trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-(Trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-(Trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(4-(Trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-tert-Butylphenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-tert-butylphenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-(Methylsulfonyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((Trans-2-(4-(methylsulfonyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(6-(Trifluoromethyl)pyridin-3-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(6-(trifluoromethyl)pyridin-3-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(5-tert-Butylthiophen-2-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(5-tert-Butylthiophen-2-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,4-Difluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Chloro-2-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-chloro-2-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Chloro-4-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2-chloro-4-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Chloro-3-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-chloro-3-fluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,4-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(2,4-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(2,4-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(2,4-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,5-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,5-Dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,5-dichlorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2-fluoro-4-(trifluoromethoxy)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,4,5-Trifluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,4,5-Trifluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,4,5-trifluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,4,5-Trifluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(2,4,5-Trifluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Chloro-3,5-difluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-chloro-3,5-difluorophenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-Methyl-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-Methyl-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3-methyl-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,5-Difluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,5-difluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Methyl-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2-fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-Fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-phenylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-phenylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Cyclohexylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-Cyclohexylpiperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Methyl-2H-tetrazol-5-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2-methyl-2H-tetrazol-5-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(1-Methyl-1H-tetrazol-5-yl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(Cyclohexyloxymethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(Cyclohexyloxymethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(cyclohexyloxymethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(Difluoromethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(difluoromethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-((4,4-Difluorocyclohexyl)methyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-((4,4-Difluorocyclohexyl)methyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-((4,4-difluorocyclohexyl)methyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(4-Fluorophenethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(4-Fluorophenethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-fluorophenethyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(3,3-Dimethylbutyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,3-Dimethylbutyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(4-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(3-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(2-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((42R,4R)-2-(2-Fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(4-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(4-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2-(Trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(2-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-(Trifluoromethoxy)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-(trifluoromethoxy)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-Chlorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-chlorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(4-(Methylsulfonyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(4-(Methylsulfonyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(4-(methylsulfonyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(3,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(3,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(2,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2,5-difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,6-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(2,6-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2,6-difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4S)-2-(3,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4R)-2-(3,5-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(2,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(2,4-Difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(2,4-difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-Fluoro-5-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-Fluoro-5-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3-fluoro-5-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3-Fluoro-4-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3-Fluoro-4-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3-fluoro-4-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,4,5-Trifluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,4,5-Trifluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,4,5-trifluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-(3,5-Di-tert-butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2S,4R)-2-(3,5-Di-tert-butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-(Trans-2-(3,5-di-tert-butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one; 5-((2R,4S)-2-Benzyl-2,3,4,5,6-d 5-((2S,4R)-2-Benzyl-2,3,4,5,6-d 5-(Trans-2-benzyl-2,3,4,5,6-d and pharmaceutically acceptable salts thereof.