Patent ID: 8232084
Filing Date: 2012-07-31
Classification: G01N

Abstract:
1. A device for measuring an extracellular potential of a test cell, said device comprising: a substrate including a well formed in the base and the intermediate layer such that the well extends from the base to an exposed portion of the first surface of the plate, wherein the through-hole is arranged such that an opening of the through-hole opens to a bottom of the well so as to allow the well to communicate with the second surface of the plate, the through-hole having an inner wall surface which extends from the bottom of the well to the second surface of the plate; an insulator arranged such that a first portion of the insulator is provided on the exposed portion of the first surface of the plate within the well, the first portion of the insulator being connected to the intermediate layer, and such that a second portion of the insulator is provided on the base; and an electrode, wherein the intermediate layer has a resistivity greater than a resistivity of the plate, wherein the intermediate layer has a side surface exposed to an interior of the well, and the base has a side surface facing towards the interior of the well, wherein the second portion of the insulator is provided on the side surface of the base and is connected directly to the side surface of the intermediate layer so as to prevent the side surface of the base from being exposed to the interior of the well, wherein the electrode is arranged such that a first portion of the electrode is provided along the second surface of the plate, and such that a second portion of the electrode is provided along the inner wall surface of the through-hole, and wherein the through-hole is arranged to allow the test cell to be held at the opening of the through-hole.