Patent ID: 7229641
Filing Date: 2007-06-12
Classification: A61K

Abstract:
1. A method of preparing an oral dosage composition that rapidly disintegrates in a mouth of a mammal comprising the steps of: a) melting at least one binder in an amount from about 0.01% to about 70% by weight with a salivating agent in an amount from about 0.05% to about 15% by weight, to form a first mixture b) mixing a therapeutically effective amount of an active ingredient with at least one lubricant to form a second mixture wherein said lubricant is selected from the group consisting of fats, emulsifiers, magnesium stearate, calcium stearate, talc, starches, silicon dioxide, and mixtures thereof; c) combining said first mixture with said second mixture to form a compressible mixture; d) compressing said compressible mixture into an oral dosage composition; e) heating said oral dosage composition to a temperature 40 to 60° C. for a period of 1 to 10 minutes in order to convert said kinder to a bonding agent; and f) cooling said heated oral dosage composition, wherein said composition disintegrates without the necessity of biting or chewing in the mouth of said mammal less than 20 seconds of administration.