Patent ID: 6423494
Filing Date: 2002-07-23
Classification: G01N

Abstract:
A method for determining whether a test compound alters the expression of DR6 mRNA in a cell, the method comprising:a) measuring the level of DR6 mRNA in a sample comprising cells not exposed to the test compound; b) measuring the level of DR6 mRNA in a sample comprising cells exposed to the test compound; and c) determining that test compound alters the expression of DR6 mRNA when the level of DR6 mRNA measured in step a) differs from the level of DR6 mRNA measured in step b); wherein the DR6 mRNA is selected from the group consisting of: i) an mRNA comprising the nucleotide sequence of SEQ ID NO:3 wherein each T is replaced by a U; ii) an mRNA encoding the amino acid sequence of SEQ ID NO:2; and iii) an mRNA comprising the coding sequence of the cDNA insert of plasmid epDR6 deposited with the ATCCÂ® as Accession No. PTA-1881 wherein each T is replaced by a U.