Patent ID: 6068858
Filing Date: 2000-05-30
Classification: A61K

Abstract:
A method of preparing a nanoparticulate composition comprising a crystalline HIV protease inhibitor having a solubility in water of less than about 10 mg/ml, said HIV protease inhibitor having adsorbed on the surface thereof a cellulosic surface stabilizer in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, wherein said method comprises:(1) dispersing a HIV protease inhibitor in a liquid dispersion medium, wherein the HIV protease inhibitor is poorly soluble and dispersible in the liquid dispersion medium;(2) wet grinding the HIV protease inhibitor in the presence of rigid grinding media having an average particle size of less than about 3 mm and a cellulosic surface stabilizer to reduce the particle size of the HIV protease inhibitor to an effective average particle size of less than about 1000 nm; and(3) isolating the resultant nanoparticulate HIV protease inhibitor composition from the grinding media.