Patent ID: 6376648
Filing Date: 2002-04-23
Classification: A61K,A61P,C07K

Abstract:
An kallikrein inhibitor comprising the sequence (SEQ ID NO: 1):X1-Val-Cys-Ser-Glu-Gln-Ala-Glu-X2-Gly-X3-Cys-Arg-Ala-X4-X5-X6-X7-Trp-Tyr-Phe-Asp-Val-Thr-Glu-Gly-Lys-Cys-Ala-Pro-Phe-X8-Tyr-Gly-Gly-Cys-X9-X10-X11-X12-Asn-Asn-Phe-Asp-Thr-Glu-Glu-Tyr-Cys-Met-Ala-Val-Cys-Gly-Ser-Ala-Ile, wherein:X1 is selected from Glu-Val-Val-Arg-Glu (SEQ ID NO: 2), Asp, or Glu; X2 is selected from Thr, Val, Ile and Ser; X3 is selected from Pro and Ala; X4 is selected from Arg, Ala, Leu, Gly, or Met; X5 is selected from Ile, His, Leu, Lys, Ala, or Phe; X6 is selected from Ser, Ile, Pro, Phe, Tyr, Trp, Asn, Leu, His, Lys, or Glu; X7 is selected from Arg, His, or Ala; X8 is selected from Phe, Val, Leu, or Gly; X9 is selected from Gly, Ala, Lys, Pro, Arg, Leu, Met, or Tyr; X10 is selected from Ala, Arg, or Gly; X11 is selected from Lys, Ala, or Asn; X12 is selected from Ser, Ala, or Arg; provided that:when X4 is Arg, X6 is Ile; when X9 is Arg, X4 is Ala or Leu; when X9 is Tyr, X4 is Ala or X5 is His; and either X5 is not Ile; or X6 is not Ser; or X9 is not Gly, Leu, Met, or Tyr, or X10 is not Gly; or X11 is not Asn; or X12 is not Arg.