Patent ID: 7015213
Filing Date: 2006-03-21
Classification: A61P,C07D

Abstract:
1. A method for treating a condition selected from the group consisting of acromegalia, hypophyseal adenomas and endocrinic gastroenteropancreatic tumors in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound selected from the group consisting of a compound of the formula wherein W is hydrogen or R—X—C(Y)—, R is unsubstituted or substituted aryl or heteroaryl with at least one substituent selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, lower alkylsulfonyl, halogen, —CF 3 , —OCF 3 , —OH, —NO 2 , —CN, aryl, aryloxy, cycloalkyl and heterocycloalkyl, X is —(CH 2 ) n — Z , Z is selected from the group consisting of a covalent bond, —NH—, —O— and —S—, n is 0, 1 or 2, Y is oxygen or sulfur, R 1 is selected from the group consisting of hydrogen, —OH, halogen, lower alkyl and lower alkoxy, the alkyl and alkoxy being unsubstituted or substituted with at least one member of the group consisting of —CF 3 , lower alkoxy, —NH 2 and mono- and di-lower alkylamino, R 2a and R 2b are individually hydrogen or methyl, R 3 is selected from the group consisting of hydrogen, halogen, —NO 2 , —CN, unsubstituted or substituted alkyl of 1 to 10 carbon atoms, unsubstituted or substituted lower alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aralkyl, unsubstituted or substituted lower aryloxyalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl and —Z 31 R 31 , the substituents being selected from the group consisting of halogen, aryl, and —Z 32 —R 34 , Z 31 is selected from the group consisting of —O—, —C(O)—, —OC(O)— and —S—, R 31 is selected from the group consisting of hydrogen, lower alkyl, aryl and lower aralkyl, R 32 and R 33 are individually selected from the group consisting of hydrogen, lower alkyl, aralkyl and alkylcarbonyl or together with the nitrogen form a heterocycloalkyl, Z 32 is selected from the group consisting of oxygen, sulfur, —C(O)—, —S(O)—, —O—CO— and —SO 2 —, R 34 is selected from the group consisting of hydrogen, lower alkyl, aryl and lower aralkyl and its non-toxic pharmaceutically acceptable salts sufficient to treat said condition.