Patent ID: 6177423
Filing Date: 2001-01-23
Classification: A61P,C07D,Y02P

Abstract:
A compound of Formula I ##STR27##or a pharmaceutically acceptable salt thereofwherein:R is hydrogen;R.sub.1 -R.sub.5 are each independently chosen from H, Cl, Br, F, a heterocycle or bridged heterocycle of 4-9 atoms containing 1-3 heteroatoms, NO.sub.2, OCH.sub.3, CH.sub.3, and any two of R.sub.1 -R.sub.5 may form a substituted or unsubstituted ring of 5-7 total atoms having 0-2 heteroatoms and at least one or R.sub.1 -R.sub.5 is a heterocycle;n is an integer of from 0 to 5;m is an integer of from 0 to 3;R.sub.6 and R.sub.7 are independently hydrogen, a straight or branched alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons, a heterocycle of 5-6 atoms with 1-3 heteroatoms, or Ph, all of which may be optionally substituted;R.sub.8 is a cycloalkyl of 3-7 carbons or a heterocycle of 4-9 atoms with 1-4 heteroatoms;R' is R.sub.6, F, Br, Cl, OR.sub.6, N(R.sub.6).sub.2, and any two R's may form a ring of 3-6 total atoms with 0-2 heteroatoms;wherein the alkyls, cycloalkyls, heterocycles, and Ph may be optionally substituted; andwherein the substituents are selected from a straight or branched alkyl of 1-4 carbons, Br, F, Cl, --(CR'.sub.2).sub.n OR.sub.6, --(CR'.sub.2).sub.n N(R.sub.6).sub.2, --(CR'.sub.2).sub.n NR.sub.6 COR.sub.7, --(CR'.sub.2).sub.n NR.sub.6 SO.sub.2 OR.sub.7, --(CR'.sub.2).sub.n NR.sub.6 SO.sub.2 N(R.sub.6).sub.2, --(CR'.sub.2).sub.n OSO.sub.2 N(R.sub.6).sub.2, --(CR'.sub.2).sub.n CN, --(CR'.sub.2).sub.n C(NOR.sub.6)R.sub.7, NO.sub.2, CF.sub.3, --(CR'.sub.2).sub.n SO.sub.m R.sub.7, --(CR'.sub.2).sub.n CO.sub.2 R.sub.6, --(CR'.sub.2).sub.n R.sub.8, --(CR'.sub.2).sub.n CON(R.sub.6).sub.2, and Ph.