Patent ID: 7935819
Filing Date: 2011-05-03
Classification: A61P,C07D

Abstract:
1. A compound of formula (I): in which: Ra and Rb represent CH3 or form, together with the carbon atom to which they are attached, a cycloalkyl radical, X1 and X2 are such that: either one represents hydrogen and the other represents alkyl, or one represents —OCF3 or —SCF3 and the other represents the radical NH—CO—R6, or X1 and X2 form, with the phenyl radical to which they are attached, a dihydroindole radical optionally substituted with one or more alkyl radicals and on its nitrogen atom with a radical CO-alkyl-R3, R represents a pyridyl or pyrimidinyl radical substituted with a radical NR1R2, NR1R2 being such that: one from among R1 and R2 represents a hydrogen atom or an alkyl radical, and the other from among R1 and R2 is chosen from a hydrogen atom and alkyl radicals optionally substituted with a radical chosen from hydroxyl, alkoxy, aziridyl, azetidinyl, pyrrolidinyl, piperidyl, morpholinyl, and piperazinyl, which is itself optionally substituted on its second nitrogen atom with an alkyl radical; optionally substituted cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals; and the radical CO—R3 with R3 chosen from NR4R5 and optionally substituted alkoxy, heterocycloalkyl, aryl, aryloxy and heteroaryl radicals; R4 and R5, which may be identical to or different from R1 and R2, are such that: either one from among R4 and R5 represents a hydrogen atom or an alkyl radical, and the other from among R4 and R5 is chosen from a hydrogen atom and alkyl radicals optionally substituted with a radical chosen from hydroxyl, alkoxy, aziridyl, azetidinyl, pyrrolidinyl, piperidyl, morpholinyl, and piperazinyl, which is itself optionally substituted on its second nitrogen atom with an alkyl radical; optionally substituted cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals; or R4 and R5 form, with the nitrogen atom to which they are attached, a cyclic amine optionally containing another heteroatom chosen from N and O, which is optionally substituted, all the above aryl, phenyl, aryloxy and heteroaryl radicals, and also the cyclic amine NR4R5, being optionally substituted with one to three radicals, which may be identical or different, chosen from halogen atoms and alkyl, phenyl, NH2, NHAlk, N(Alk)2, CO—NHAlk and CO—N(Alk)2 radicals; R6 represents alkyl optionally substituted with one or more radicals, which may be identical or different, chosen from the values of R3, or an addition salt with a mineral or organic acid or with a mineral or organic base of said compound of formula (I); said compound being in any possible racemic, enantiomeric or diastereoisomeric isomer form.