Patent ID: 9180261
Filing Date: 2015-11-10
Classification: A61K,A61M,A61P

Abstract:
1. A method for aerosolizing an insulin formulation, the method comprising: providing a preservative free insulin formulation comprising a major amount of water, and minor amounts of insulin, HCl and NaOH; supplying an amount of the insulin formulation in the range from about 40 μL to about 200 μL to a rear side of an aperture plate having a plurality of apertures where the amount is stored while resting on the rear side by force of gravity, wherein the aperture plate is dome shaped in geometry, and wherein the aperture plate is vibrated by an annular piezoelectric element that circumscribes the apertures; vibrating the aperture plate with the annular piezoelectric element while the amount of the insulin formulation is at the rear side, wherein vibration causes the supplied insulin to be ejected from a front side of the aperture plate that is beneath the rear side as an aerosolized spray without substantial foaming of the insulin formulation.