Patent ID: 6645970
Filing Date: 2003-11-11
Classification: A61K,A61P,C07D

Abstract:
A compound of formula I whereinRa is H; C1-4alkyl; or C1-4alkyl substituted by OH, NH2, NHC1-4alkyl or N(C1-4alkyl)2; Rb is H; or C1-4alkyl; R is a radical of formula (d) or (e) â€ƒwherein each of R8, R11 and R14 is OH; SH; a heterocyclic group, NR16R17 wherein each of R16 and R17, independently, is H or C1-4alkyl; or a radical of formula &agr;â€”Xâ€”Rcâ€”Yâ€ƒâ€ƒ(&agr;) wherein X is a direct bond, O, S or NR18 wherein R18 is H or C1-4alkyl, Rc is C1-4alkylene or C1-4alkylene wherein one CH2 is replaced by CRxRy wherein one of Rx and Ry is H and the other is CH3, each of Rx and Ry is CH3 or Rx and Ry form together â€”CH2â€”CH2â€”, and Y is bound to the terminal carbon atom and is selected from OH, a heterocyclic group residue and NR19R20 wherein each of R19 and R20 independently is H, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, aryl-C1-4alkyl or C1 4alkyl optionally substituted on the terminal carbon atom by OH, each of R9, R10, R12, R13, independently, is H, halogen, C1-4alkyl, CF3, OH, SH, NH2, C1-4alkoxy, C1-4alkylthio, NHC1-4alkyl, N(C1-4alkyl)2 or CN; E is â€”CH&boxH; and G is â€”N&boxH;; and ring A is optionally substituted, or a salt thereof.