Patent ID: 6403656
Filing Date: 2002-06-11
Classification: A61K,A61P,Y10S

Abstract:
A method for treating skin disorders related to an abnormality of the differentiation of epidermal cells comprising administering an effective amount of at least one activator of receptors of the PPAR-&ggr; type wherein the disorder related to an abnormality of the differentiation of epidermal cells is selected from the group consisting of psoriasis, eczema, lichen planus, skin lesions associated with lupus, dermatitides, seborrho or solar dermatitis, keratoses, senile, actinic, light-induced or follicular keratosis, common acne, keloids, nevi, warts, and ichthyoses and wherein the activator of receptors of the PPAR-&ggr; type is selected from the group consisting of 5-{4-[2-(methyl-pyrid-2-ylamino)ethoxy]benzl}thiazolidine-2,4-dione; 3-{4-[2-(benzoxazol-2-ylmethylamino)ethoxy]phenyl}-2-ethoxypropionic acid; (+)-3-{4-[2-(benzoxazol-2-ylmethylamino)ethoxy]phenyl}-2-ethoxypropionic acid; and (âˆ’)-3-{4-[2-(benzoxazol-2-ylmethylamino)ethoxy]phenyl}-2-ethoxypropionic acid.