Patent ID: 6528505
Filing Date: 2003-03-04
Classification: A61K,C07D,C07K

Abstract:
A compound which are represented by formula I or Ia below: wherein:R1 together with Râ€² and the carbon and nitrogen atoms attached thereto, respectively, form a nitrogen containing optionally substituted heterocyclic in formula I or a nitrogen containing unsaturated optionally substituted heterocyclic or an optionally substituted heteroaryl group in formula Ia; Râ€³ is selected from the group consisting of hydrogen, alkyl, substituted alkyl and an optionally substituted aryl; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted heterocyclic; and W is a cyclic group selected from the group consisting of: â€ƒwherein: each R6 is independently selected from the group consisting of acyl, acylamino, acyloxy, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, alkyl, substituted alkyl, alkynyl, substituted alkynyl, amino, substituted amino, aminoacyl, optionally substituted aryl, optionally substituted aryloxy, carboxyl, carboxyalkyl, cyano, cycloalkyl, substituted cycloalkyl, halo, optionally substituted heteroaryl, optionally substituted heterocyclic, nitro, thioalkoxy, substituted thioalkoxy, optionally substituted thioaryloxy, optionally substituted thioheteroaryloxy, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-optionally substituted aryl, â€”SO-optionally substituted heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl â€”SO2-optionally substituted aryl, and â€”SO2-optionally substituted heteroaryl; each R7 is independently selected from the group consisting of acyl, acylamino, acyloxy, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, alkyl, substituted alkyl, alkynyl, substituted alkynyl, amino, substituted amino, aminoacyl, optionally substituted aryl, optionally substituted aryloxy, carboxyl, carboxyalkyl, cyano, cycloalkyl, substituted cycloalkyl, halo, optionally substituted heteroaryl, optionally substituted heterocyclic, nitro, thioalkoxy, substituted thioalkoxy, optionally substituted thioaryloxy, optionally substituted thioheteroaryloxy, â€”SO-alkyl, â€”SO-substituted alkyl, â€”SO-optionally substituted aryl, â€”SO-optionally substituted heteroaryl, â€”SO2-alkyl, â€”SO2-substituted alkyl, â€”SO2-optionally substituted aryl, and â€”SO2-optionally substituted heteroaryl; R8 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, optionally substituted aryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, optionally substituted heteroaryl and optionally substituted heterocyclic; each R9 is independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, optionally substituted aryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, optionally substituted heteroaryl and optionally substituted heterocyclic; g is an integer from 0 to 2; p is an integer from 0 to 4; and q is an integer from 0 to 4; and pharmaceutically acceptable salts thereof.