Patent ID: 6455307
Filing Date: 2002-09-24
Classification: A61K,C12N,C12Y,Y02P

Abstract:
A compound 20 to 50 nucleobases in length targeted to nucleobases 21 through 51 or nucleobases 56 through 95 of a 5â€²-untranslated region, nucleobases 180 through 237, nucleobases 251 through 280, nucleobases 285 through 316, nucleobases 393 through 468, nucleobases 479 through 641, nucleobases 646 through 686, nucleobases 707 through 736, nucleobases 750 through 769, nucleobases 872 through 891, nucleobases 950 through 969, nucleobases 978 through 997, nucleobases 1004 through 1045, nucleobases 1056 through 1075, nucleobases 1099 through 1118, nucleobases 1146 through 1165, or nucleobases 1184 through 1203 of a coding region, a stop codon region, or a 3â€²-untranslated region of a nucleic acid molecule encoding Casein kinase 2-alpha prime of SEQ ID NO: 3, or a coding region, a stop codon region or a 3â€²-untranslated region of a nucleic acid molecule encoding mouse Casein kinase 2-alpha prime of SEQ ID NO: 10, wherein said compound specifically hybridizes with one of said regions and inhibits the expression of Casein kinase 2-alpha prime.