Patent ID: 8283456
Filing Date: 2012-10-09
Classification: A61K,A61P,C07H

Abstract:
1. A method comprising the steps of: (a) providing a mixture of prosapogenins of formula IV-a: wherein: Y′ is hydrogen, halogen, alkyl, aryl, OR, OR W is Me, —CHO, —CH 2 OR x , or —C(O)R y ; V is hydrogen or —OR R R each occurrence of R each occurrence of R is independently hydrogen, an optionally substituted group selected from acyl, arylalkyl, 6-10-membered aryl, C two R on the same nitrogen atom are taken with the nitrogen to form a 4-7-membered heterocyclic ring having 1-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur; and each occurrence of R (b) treating said mixture of prosapogenins of formula IV-a under suitable conditions to form a mixture of prosapogenins of formula IV: wherein each of with the proviso that at least one R and (c) obtaining a prosapogenin of formula IV by suitable physical means.