Patent ID: 9192583
Filing Date: 2015-11-24
Classification: A61K,A61P

Abstract:
1. A multiparticulate dosage form comprising a plurality of individual enteric coated particulates having (a) a solid core containing an effective amount of at least one volatile terpene-based active ingredient, (b) a continuous proteinaceous subcoating over the core, and (c) an enteric coating over the subcoating, the subcoating being effective to prevent the volatile terpene-based active ingredient(s) from substantially penetrating the subcoating and contacting the enteric coating when stored at a temperature of 40 degrees C. and 75% relative humidity from between 1 day to 30 days; wherein: the solid core comprises about 10% w/w to about 35% w/w of the at least one volatile terpene-based active ingredient, about 40% w/w to about 75% w/w microcrystalline cellulose, and about 2% w/w to about 10% w/w methyl cellulose; the subcoating comprises about 3.5% w/w to about 25% w/w of the enteric coated cores; and the enteric coating comprises about 2% w/w to about 35% w/w of the enteric coated cores.