Patent ID: 8173674
Filing Date: 2012-05-08
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein n is 0 or 1 R1, R2, R3, and R4 are independently H, (C1-C8) alkyl, (C0-C4) alkylene-(C3-C7) cycloalkyl, or (C0-C4) alkylene-(C6-C10) aryl, wherein the alkyl and alkylene are independently unsubstituted or 1- to 3-times substituted by F; R5 and R6 are independently H, (C1-C8) alkyl, (C0-C4) alkylene-(C3-C7) cycloalkyl, or (C0-C4) alkylene-(C6-C10) aryl, wherein the alkyl and alkylene are independently unsubstituted or 1- to 3-times substituted by F, or R5 and R6 together with the carbon atom to which they are attached form a (C3-C7) cycloalkyl ring, wherein one carbon atom can be replaced by one heteroatom selected from O, S and N; R7 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, or (C3-C7) cycloalkyl, wherein the alkyl and alkylene are unsubstituted or 1- to 3-times substituted by F; R8 and R9 are independently H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, (C3-C7) cycloalkyl, —CO—O—(C0-C4)-alkylene-H, CO—O-phenyl, or —C0-NR12R13, wherein the alkyl and alkylene are unsubstituted or 1- to 3-times substituted by F or NR12R13, and wherein the phenyl is unsubstituted or 1- to 3-times substituted by halogen, (C1-C4) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, or NR12R13, or R8 and R9 together with the carbon atoms to which they are bonded form a (C5-C7) cycloalkyl ring, wherein one carbon atom can be replaced by one heteroatom O, S, N; R10 and R11 are independently H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, (C3-C7) cycloalkyl, or (C6-C10) aryl, wherein the cycloalkyl and aryl are unsubstituted or 1- to 2-times substituted by (C1-C4) alkyl, and wherein the alkyl and alkylene are unsubstituted or 1- to 3-times substituted by F; and R12 and R13 are independently H, (C1-C6) alkyl; or a stereoisomer or tautomer thereof, or a physiologically acceptable salt thereof.