Patent ID: 6710064
Filing Date: 2004-03-23
Classification: A61P,C07D

Abstract:
A compound having the formula (I), or a pharmaceutically-acceptable salt thereof, in which:Z is hydrogen, alkyl, or substituted alkyl, except Z is not arylalkyl or heteroarylalkyl; R1 is Q-aryl or Q-heteroaryl, wherein Q is â€”Wâ€”(CH2)mâ€”; W is selected from â€”Oâ€”, â€”NR10â€”, â€”Sâ€”; R3 is attached to any available carbon atom of ring A and at each occurrance is selected independently of each other R3 from halogen, alkyl, substituted alkyl, alkenyl, nitro, cyano, OR8, NR8R9, CO2R8, (C&boxH;O)R8, C(&boxH;O)NR8R9, NR8C(&boxH;O)R9, NR8C(&boxH;O)OR9, OC(&boxH;O)R8, OC(&boxH;O)NR8R9, SR8, S(O)qR8a, NR8SO2R9, SO2NR8R9, aryl, heteroaryl, heterocyclo, cycloalkyl, and keto (&boxH;O), provided that when R3 is attached to the atom designated as the C-5 atom of ring A, then R3 is not aryl or heteroaryl; R4a and R4b are selected independently of each other from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, alkenyl, nitro, cyano, hydroxy, alkoxy, substituted alkoxy, phenyloxy, benzyloxy, CO2H, C(&boxH;O)H, amino, alkylamino, substituted alkylamino, CO2alkyl, (C&boxH;O)alkyl, and alkylthio; R8 and R9 (i) selected independently of each other are hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, alkoxy, cycoalkyl, aryl, heteroaryl, or heterocyclo; or (ii) taken together form a heterocyclo ring; R8a is alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclo; R10 is hydrogen, alkyl, or substituted alkyl; n is 0, 1, or 2; q is 1, 2, or 3; and m is 0, 1, 2, 3, or 4.