Patent ID: 8946156
Filing Date: 2015-02-03
Classification: A01K,A61K,A61P,C07K,C12N,Y02A

Abstract:
1. A fusion protein comprising: a serum cholinesterase polypeptide fused to an albumin polypeptide, wherein said serum cholinesterase polypeptide comprises a variant of serum cholinesterase, wherein the variant comprises a polypeptide having an amino acid sequence that is at least 90% identical to amino acids 29 to 602 of SEQ ID NO:52; and wherein said albumin polypeptide comprises: i) a full-length albumin; ii) a fragment of albumin; iii) a polypeptide consisting of an amino acid sequence at least 95% identical to the sequence set forth as SEQ ID NO:18; iv) amino acids 1 to 585 of SEQ ID NO:18; v) amino acids 1 to 387 of SEQ ID NO:18; vi) amino acids 1 to 194 of SEQ ID NO:18; vii) amino acids 195 to 387 of SEQ ID NO:18; viii) amino acids 388 to 585 of SEQ ID NO:18; ix) amino acids 195 to 585 of SEQ ID NO:18; or x) amino acids 1 to 194 of SEQ ID NO:18 combined with amino acids 388 to 585 of SEQ ID NO:18 wherein said fusion protein has serum cholinesterase activity and a prolonged serum half-life compared to the unfused serum cholinesterase polypeptide.