Patent ID: 8623412
Filing Date: 2014-01-07
Classification: A61K,A61P

Abstract:
1. An abuse-resistant controlled-release pharmaceutical composition comprising a plurality of microspheres, each microsphere comprises: (i) a water insoluble matrix material, and (ii) a plurality of discrete particles distributed throughout the water insoluble matrix material, each particle comprises a pharmaceutically effective amount of an active water soluble compound capable of abuse and having surfaces that are wetted with a coating of the water insoluble matrix material, wherein said water insoluble matrix material is present in an abuse-reducing amount whereby crushing, compressing, fracturing, tumbling, rolling, or milling of said controlled-release pharmaceutical composition results in an increase in the aqueous dissolution of said active water soluble compound by less than about 15% of the total pharmaceutically effective amount of the active water soluble compound in the composition in the first hour of in vitro dissolution testing, wherein the water soluble compound capable of abuse is an opioid agonist, and wherein the composition does not include an antagonist of the water soluble compound capable of abuse.