Patent ID: 8865903
Filing Date: 2014-10-21
Classification: C07D

Abstract:
1. A method for the continuous alkylation of cyclic tertiary amines comprising: continuously feeding a solution of a cyclic tertiary amine in a suitable solvent or mixture of solvents and of an alkylating agent into a continuous-flow reactor, wherein said suitable solvents or mixture of solvents are polar aprotic solvents selected from the group consisting of amides, nitriles and sulphoxides; maintaining the temperature within the range of 20-200° C.; collecting the solution containing the pure quaternary cyclic ammonium compound; and isolating the pure quaternary cyclic ammonium compound; respectively, wherein R is a linear or branched C R X is a halogen atom or a carbonate, sulfate or triflate; and A is a radical forming, optionally substituted monocyclic, bicyclic or tricyclic ring with the nitrogen atom, said ring being selected among from optionally substituted monocyclic rings having from 4 to 7 atoms, optionally including 1 or 2 heteroatoms selected among from N, O and S, in addition to the nitrogen atom to which they are linked; optionally substituted bicyclic rings having from 6 to 9 atoms, optionally including 1 or 2 heteroatoms selected among from N, O and S, in addition to the nitrogen atom to which they are linked; and optionally substituted tricyclic ring having from 8 to 12 atoms, optionally including 1 or 2 heteroatoms selected among from N, O and S, in addition to the nitrogen atom to which they are linked.