Patent ID: 9162014
Filing Date: 2015-10-20
Classification: A61K,A61L,A61M

Abstract:
1. An insertable medical device for delivering a 17β-estradiol pro-healing agent to tissues in proximity with a stent deployed in a blood vessel, the insertable medical device comprising: a catheter balloon; a surface of the catheter balloon; a plurality of nano-carriers coated on the surface, each nano-carrier of the plurality of nano-carriers of a size within a range between approximately 100 nanometers and approximately 1000 nanometers and including at least one nano-particle of the 17β-estradiol pro-healing agent surrounded by individual nano-particles of a biological agent LIPOID E80 egg lecithin mixture, each nano-particle of the biological agent LIPOID E80 egg lecithin mixture of a size within a range between approximately 70 nanometers and approximately 500 nanometers, wherein the plurality of nano-carriers are released from the catheter balloon to the tissues in response to expanding the catheter balloon at the tissues, wherein the plurality of nano-carriers upon releasing from the catheter balloon penetrate the tissues leading to dissolution of the nano-particles of the biological agent LIPOID E80 egg lecithin mixture and subsequent release of the 17β-estradiol pro-healing agent in the tissues; wherein the surface is on the catheter balloon and comprises a layer of a hydrophilic lubricious coating material coated on one or more portions of the surface, the surface further comprising one or more exposed hydrophilic lubricious surfaces, the one or more exposed hydrophilic lubricious surfaces created at one or more portions of the catheter balloon by not coating each exposed hydrophilic lubricious surface with the plurality of nano-carriers on the one or more portions of a distal end of the hydrophilic lubricious surface and one or more portions of a proximal end of the hydrophilic lubricious surface; the surface further comprising one or more underlying hydrophilic lubricious surfaces between the nano-carriers and the catheter balloon; and wherein the exposed hydrophilic lubricious surfaces dissolve rapidly when exposed to the tissues thereby exposing a part of the one or more underlying hydrophilic lubricious surfaces to the tissues causing a rapid release of approximately 70% to 80% of the nano-carries from the catheter balloon within approximately 60 seconds when the catheter balloon is inflated.