Patent ID: 6399568
Filing Date: 2002-06-04
Classification: A61K,A61P,C07K

Abstract:
A cyclic tetrapeptide derivative represented by any of the following general formulae (I), (Iâ€²), (Iâ€³), and (Iâ€²â€³): wherein:R11, R12, R21 and R22 independently denote a monovalent group selected from hydrogen, a linear alkyl group with 1 to 6 carbon atoms, a branched alkyl group with 3 to 6 carbon atoms, a linear &ohgr;-aminoalkyl group with 1 to 5 carbon atoms, a branched aminoalkyl group with 3 to 5 carbon atoms, an N-acyl-aminoalkyl group which is formed by substituting the amino group on said linear &ohgr;-aminoalkyl or branched aminoalkyl groups with an acyl group or a halogeno-substituted acyl group that has 3 or less carbon atoms, a benzyl group, a 4-methoxybenzyl group, a 3-indolylmethyl group, an (N-methoxy-3-indolyl)methyl group, an (N-acyl-3-indolyl)methyl group having an acyl group with 3 or less carbon atoms as a substituent on the ring-forming nitrogen atom, and a methyl group substituted with an aryl group comprising 4 or less rings; R3 denotes a divalent group selected from a linear alkylene group with 3 or 4 carbon atoms in the chain which may have a branched chain on the chain; a linear alkenylene group with 3 or 4 carbon atoms in the chain which may have a branched chain on the chain; a linear alkadienylene group with 4 carbon atoms in the chain which may have a branched chain on the chain; a divalent group in which the branched chain added onto said linear alkylene, linear alkenylene or alkadienylene group forms a fused ring structure; and a divalent group in which among the carbon atoms constituting the linear alkylene, linear alkenylene or alkadienylene group, one of the carbon atoms other than that having a free valence has been replaced with a heteroatom oxygen, sulfur or nitrogen; R4 denotes a divalent group having a chained hydrocarbon group with 4 to 6 carbon atoms in the chain which may have a branched chain on said chain, or a divalent group in which among the carbon atoms constituting the chained hydrocarbon group, at least one of the carbon atoms other than that having a free valence has been replaced with a heteroatom oxygen, sulfur or nitrogen; and R5 in the general formulae (Iâ€³) or (Iâ€²â€³) denotes a methyl group or halogeno-substituted methyl group, or a pharmaceutically acceptable salt thereof.