Patent ID: 6617322
Filing Date: 2003-09-09
Classification: A61K,A61P,C07D

Abstract:
A method to identify a blocker of ion channel activity which method comprises contacting cells which display an ion channel of interest with a candidate compound under conditions wherein activation of said ion channel would occur in the absence of said compound; andassessing the ability of said candidate compound to inhibit said activation whereby a candidate compound whose presence results in inhibition of activation is identified as a blocker of said ion channel, and wherein said library comprises compounds of the formula wherein m is 0, 1 or 2; wherein when m is 0, Z is 0, when m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH2, or an organic moiety of 1-20C, optionally additionally containing 1-8 heteroatoms selected from the group consisting of N, P, O, S and halo; each l1 and l2 is independently 0-5; l3 is 0 or 1; each of R1, R2 and R3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R1 and R2 may independently be halo, COOR, CONR2, CF3, CN or NO2, wherein R is H or lower alkyl (1-4C) or alkyl (1-6C); n is 0 or 1; and X is a linker.