Patent ID: 7626014
Filing Date: 2009-12-01
Classification: A61P,C07H,C12N

Abstract:
1. A double-stranded oligonucleotide comprising a first strand and a second strand, wherein said first strand and said second are represented independently by formula I: wherein X is H, —P(O)(OM) Z Z R R R R R R n m represents independently for each occurrence 1, 2, 3, 4, 5, 6, 7, or 8; m v represents independently for each occurrence 1, 2, 3, or 4; w represents independently for each occurrence 1, 2, or 3 in accord with the rules of valence; y represents independently for each occurrence 1, 2, 3, 4, or 5 in accord with the rules of valence; M represents independently for each occurrence an alkali metal or a transition metal with an overall charge of +1; A A A A B B R represents independently for each occurrence hydrogen or alkyl; A wherein R A B B A p represents independently for each occurrence 1, 2, 3, or 4; B A B B A B A B B A B