Patent ID: 8013152
Filing Date: 2011-09-06
Classification: A61P,C07D

Abstract:
1. A compound of formula I: wherein: a is 0 or an integer of from 1 to 5; each R b is 0 or an integer of from 1 to 4; each R W is —O— or —NW c is 0 or an integer from 1 to 5; each R m is 0 or 1; Z is selected from —C(O)N(R s is 0, 1 or 2; Ar is a phenylene substituted with (R t is 0, 1 or 2; R or optionally substituted with one to three —C 1-5 alkyl groups, or where: d is 1 or 2; e is 0, 1 or 2; f is 0, 1, 2 or 3; R 8 is selected from —C 1-5 alkyl and ═O; R 9 is selected from —H, —C 1-5 alkyl, hydroxyphenyl, heteroaryl, and —X 9 R 9a ; where X 9 is selected from —C 1-5 alkylene, —C(O)—, —C 1-5 alkylene-C(O)—, —C(O)—C 1-5 alkylene, —S(O 2 )—, —C 1-5 alkylene-S(O 2 )—, and —S(O 2 )—C 1-5 alkylene; and R 9a is selected from —H, —OH, —C 1-5 alkyl, —C 1-5 alkoxy, aryl, heteroaryl, heterocyclyl, and —NR 9b R 9c , where R 9b and R 9c are independently —H or —C 1-5 alkyl; wherein each alkyl and alkoxy group in R or a pharmaceutically acceptable salt or stereoisomer thereof.