Patent ID: 6903102
Filing Date: 2005-06-07
Classification: A61P,C07D

Abstract:
1. A compound of the formula (I): or a pharmaceutically acceptable salt of said compound wherein, R a) halogen; b) —OCF c) —CF d) —CN; e) alkyl or R f) heteroalkyl or R g) aryl or R h) heteroaryl or R i) arylalkyl or R j) heteroarylalkyl or R k) hydroxy; l) alkoxy; m) aryloxy; n) —SO o) —NR p) —N(R q) methylenedioxy; r) difluoromethylenedioxy; s) trifluoroalkoxy; t) —SCH u) —SO R R  and  provided that when Z and/or X is N, then R R R R R R R R R X is N and Z is C, wherein the term “heteroaryl” refers to 5- or 10-membered single or benzofused aromatic ring consisting of 1 to 3 heteroatoms independently selected from the group consisting of —O—, —S, and —N═, provided that the rings do not possess adjacent oxygen and/or sulfur atoms, wherein said heteroaryl can be unsubstituted or substituted with one, two, or three substituents independently selected from lower alkyl, halo, cyano, nitro, haloalkyl, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino and dialkylamino; the term “heteroarylalkyl” refers to a heteroaryl group bonded through an alkyl group; the term “heterocycloalkyl” refers to a non-aromatic, heterocyclic ring of 3-7 atoms containing 1-3 heteroatoms selected from N, O and S; and the term “heteroalkyl” refers to an alkyl group containing at least one heteroatom.