Patent ID: 8088380
Filing Date: 2012-01-03
Classification: A61P,C07K

Abstract:
1. A method for inducing lysis of a tumor cell that expresses EGFR, comprising contacting the tumor cell with an antigen binding molecule (ABM) in an amount effective to induce lysis of the tumor cell, wherein the ABM comprises a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain comprises a sequence selected from the group consisting of: SEQ ID NO:28, SEQ ID NO:129, SEQ ID NO:130, SEQ NO:131, SEQ ID NO:132, SEQ NO:133, SEQ ID NO:134, SEQ NO:136, and SEQ ID NO:138; wherein the light chain variable domain comprises a sequence selected from the group consisting of: SEQ ID NO:45, SEQ NO:139, SEQ ID NO:140, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, and SEQ NO:147; and wherein the ABM binds to EGFR expressed on the tumor cell and is capable of competing with the ICR62 antibody for binding to EGFR.