Patent ID: 6399614
Filing Date: 2002-06-04
Classification: C07D

Abstract:
A compound of the formula whereinR=hydrogen; R1 is chosen from the group consisting of hydrogen and lower alkyl; R2 is chosen from the group consisting of alkoxy, phenoxy, nitro, cyano, acyl, amino, acylamino, alkylsulphonylamino, alkoxycarbonyl, N-acylaminocarbonyl, N-alkylaminocarbonyl, N,N,-dialkylaminocarbonyl, aminocarbonyl, halo, trifluoromethyl or polyfluroalkoxy group; n=1 or 2; B is chosen from the group consisting of, optionally substituted aryl, optionally substituted bicyclic aryl group, optionally substituted 9-member bicyclic heteroaromatic containing one heteroatom, and an optionally substituted benzyl group, with the proviso that if B is aryl and is substituted by an alkoxy group, the alkoxy group must be at the two position; if R1 is hydrogen and R2 is a nitro group and n=1, then B cannot be a phenyl, 2 methoxyphenyl 4-chlorophenyl, 3 acetylphenyl, 3,4,5 trimethoxyphenyl, 2-chloro-4-methylphenyl or 2-pyridyl group; and if R is hydrogen and B is an optionally substituted phenyl ring, then R2 cannot be acyl, acylamino, alkoxycarbonyl, N-acylaminocarbonyl, N-alkylamino carbonyl or N,N-dialkylamino carbonyl; or enantiomers, N-oxides, hydrates, and pharmaceutically acceptable salts thereof.