Patent ID: 8715691
Filing Date: 2014-05-06
Classification: A61K,A61P,C07K,C12N

Abstract:
1. An isolated or recombinant polypeptide, which polypeptide is selected from the group consisting of: a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1; b) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1 comprising at least one amino acid substitution selected from the group consisting of K119E, K119N and A186D; c) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1 comprising the K119E and A186D amino acid substitutions; d) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1 comprising the K119N and A186D amino acid substitutions; e) a polypeptide comprising an amino acid sequence of SEQ ID NO: 1 comprising a D222G and/or Q223R substitution; f) a polypeptide comprising an amino acid sequence of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising at least one amino acid substitution selected from the group consisting of K119E, K119N and A186D; g) a polypeptide comprising an amino acid sequence of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising the K119E and A186D amino acid substitutions; h) a polypeptide comprising an amino acid sequence of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising the K119N and A186D amino acid substitutions; i) a polypeptide comprising the amino acid sequence of residues 1-327 of SEQ ID NO:1; j) a polypeptide comprising the amino acid sequence of residues 1-327 of SEQ ID NO: 1 comprising at least one amino acid substitution selected from the group consisting of K119E, K119N and A186D; k) a polypeptide comprising the amino acid sequence of residues 1-327 of SEQ ID NO: 1 comprising the K119E and A186D amino acid substitutions; l) a polypeptide comprising the amino acid sequence of residues 1-327 of SEQ ID NO: 1 comprising the K119N and A186D amino acid substitutions; m) a polypeptide comprising an amino acid sequence of residues 1-327 of SEQ ID NO: 1 comprising a D222G and/or Q223R substitution; n) a polypeptide comprising an amino acid sequence of residues 1-327 of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising at least one amino acid substitution selected from the group consisting of K119E, K119N and A186D; o) a polypeptide comprising an amino acid sequence of residues 1-327 of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising the K119E and A186D amino acid substitutions; p) a polypeptide comprising an amino acid sequence of residues 1-327 of SEQ ID NO: 1 (i) comprising a D222G and/or Q223R substitution, and (ii) further comprising the K119N and A186D amino acid substitutions; q) a polypeptide comprising the amino acid sequence of SEQ ID NO:6; r) a polypeptide comprising the amino acid sequence of residues 1-327 of SEQ IDNO:6; s) a polypeptide comprising an amino acid sequence having at least 95%, at least 98%, at least 98.5%, at least 99%, at least 99.2%, at least 99.4%, at least 99.6%, at least 99.8% or at least 99.9% sequence identity to the amino acid sequence of the polypeptide of any one of (a) to (r); t) a polypeptide comprising an amino acid sequence of the polypeptide of any one of (a) to (r) in which less than 3, less than 5, less than 10, less than 15, less than 20 amino acid residues were substituted, deleted or inserted; u) a polypeptide comprising an amino acid sequence of the polypeptide of anyone of (a) to (r) and further comprising the H273Y substitution; and v) a polypeptide comprising the amino acid sequence of SEQ ID NO:8.