Patent ID: 6017458
Filing Date: 2000-01-25
Classification: B01D,B01J,G01N

Abstract:
A process of producing an improved chromatographic separation material comprising any of the following steps:(a) reacting a regiodefined mono- (or di)azido perfunctionalized cyclodextrin with a support that carries free NH.sub.2 groups;(b) reacting a regiodefined mono- (or di)azido perfunctionalized cyclodextrin with an alkenyl amine to produce a product comprising a C.dbd.C group linked to a side chain via a urethane linkage, further hydrosilating the C.dbd.C group of said product with an active silane, and chemically immobilizing the product onto the surface of a support;(c) reacting a regiodefined mono- (or di)azido perfunctionalized cyclodextrin with an aminosilane containing at least one further reactive group to form a product, and chemically immobilizing the product onto a surface of a support; and(d) reducing a regiodefined mono- (or di)azido perfunctionalized cyclodextrin to a mono- or diamino perfunctionalized cyclodextrin, and then anchoring the mono- or diamino perfunctionalized cyclodextrin onto the surface of a support by a coupling reagent.