Patent ID: 7541043
Filing Date: 2009-06-02
Classification: A61K,A61P,C12N,Y02A

Abstract:
1. An immunoprotective composition comprising Salmonella enterica serovar Typhi strain Ty21a expressing an antigen comprising the S. sonnei form I O-polysaccharide wherein said strain Ty21a comprises a polynucleotide comprising the genes wbgT, wbgU, wzx, wzy, wbgV, wbgW, wbgX, wbgY, and wbgZ from the S. sonnei rfb/rfc gene cluster or Plesiomonas shigelloides ( P. shigelloides ) O17 gene cluster operably linked to transcriptional promoter and termination signals, wherein the polynucleotide does not include at least one of the following genes: IS1, wzz, IS630, aqpZ, IS629, IS91, and IS911.