Patent ID: 7214793
Filing Date: 2007-05-08
Classification: C07D

Abstract:
1. A method of preparing 10H-dibenzo[b,f][1,4]thiazepin-11-one represented by Formula 1, comprising the steps of: (a) reacting dithiosalicylic acid represented by Formula 2 with 1-chloro-2-nitrobenzene in a basic aqueous solution in the presence or absence of a reducing agent, to prepare 2-(2-nitrophenylsulfuryl)benzoic acid represented by Formula 3; (b) subjecting the 2-(2-nitrophenylsulfuryl)benzoic acid represented by Formula 3 to nitro group reduction in the presence of hydrogen gas, a solvent and a heterogeneous metal catalyst, to prepare 2-(2-aminophenylsulfuryl)benzoic acid represented by Formula 4; and (c) directly cyclizing the 2-(2-aminophenylsulfuryl)benzoic acid represented by Formula 4 in an organic solvent in the presence or absence of an acid catalyst: