Patent ID: 6352844
Filing Date: 2002-03-05
Classification: A61K,A61P,Y10S

Abstract:
A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a hyperproliferative disorder treatment effective amount of:(a) a ceramide-generating retinoid comprising a retinoic acid derivative or a pharmaceutically acceptable salt thereof; and (b) a ceramide degradation inhibitor or a pharmaceutically acceptable salt thereof; wherein said hyperproliferative disorder is a tumor selected from the group consisting of neuroblastoma, lung cancer, melanoma, prostate cancer, colon cancer, breast cancer, and pancreatic cancer; and wherein the retinoic acid derivative is given in an amount effective to produce necrosis, apoptosis, or both in the tumor, and the ceramide degradation inhibitor is given in an amount effective to increase the necrosis, apoptosis or both produced in the tumor over that expected to be produced by the sum of that produced by the retinoic acid derivative and the ceramide degradation inhibitor when given separately.