Patent ID: 6503703
Filing Date: 2003-01-07
Classification: A61K,C07K,C12N,G01N

Abstract:
A method for identifying a test compound that inhibits the interaction between an NS1-BP protein and an influenza virus NS1 protein, said method comprising:a) contacting an NS1-BP protein or a peptide fragment of the NS1-BP protein comprising the binding site for an NS1 protein with an immobilized NS1 protein or a peptide fragment of the NS1 protein comprsing the binding site for an NS1-BP protein, under conditions and for a time sufficient to pemit the NS1-BP protein or NS1-BP peptide fragment to bind to and form a complex with the NS1 protein or NS1 peptide fragment; b) removing unbound NS1-BP protein or NS1-BP peptide fragment; and c) detecting the complex, so if there is a decrease in the complex detected in c) as compared to the amount of complex detected in the absence of the test compound, a test compound that inhibits the interaction between an NS1-BP protein and an NS1 protein is identified.