Patent ID: 6200599
Filing Date: 2001-03-13
Classification: A61K,A61P,C07D

Abstract:
A compound having the formula ##STR4##wherein:R.sup.1 is a member selected from the group consisting of optionally substituted (C.sub.7 -C.sub.17)alkyl, optionally substituted (C.sub.7 -C.sub.17)alkenyl and optionally substituted (C.sub.7 -C.sub.17)alkynyl;R.sup.2 is a member selected from the group consisting of (C.sub.1 -C.sub.18)alkoxy and (C.sub.1 -C.sub.18)alkylthio;R.sup.3 is hydrogen; alternatively,R.sup.2 and R.sup.3 and the carbons to which they are bound join to form a 5,6-membered; a 6,6-membered; a 6,7-membered; or a 7,7-membered bicyclic ortho ester or ortho thioester ring;A and A.sup.1 are members independently selected from the group consisting of oxygen and sulfur;x and y are independently selected from the integers 0, 1 and 2;Z is a member selected from the group consisting of optionally substituted alkylene, optionally substituted alkyleneoxyalkylene and optionally substituted alkyleneaminoalkylene;Q is a member selected from the group consisting of carboxyl, thiocarboxyl, dithiocarboxyl, carbonate, carbamate, phospho, phosphothio, phosphoro and thiophosphoro; andR.sup.4 is a nitrogen containing headgroup wherein the nitrogen can be unsubstituted, mono-substituted, di-substituted, or a quaternary nitrogen salt and wherein the nitrogen substituent(s) are member(s) independently selected from the group consisting of optionally substituted (C.sub.1 -C.sub.18)alkyl, optionally substituted (C.sub.1 -C.sub.18)alkenyl, and optionally substituted (C.sub.1 -C.sub.18)alkynyl and wherein R.sup.4 and Q are optionally linked with a (C.sub.1 -C.sub.5)alkylene or (C.sub.2 -C.sub.5)alkenyl group.