Patent ID: 8962586
Filing Date: 2015-02-24
Classification: A61K,A61P,C12N,C12Q,C12Y

Abstract:
1. A method of upregulating function of and/or the expression of a Pyrroline-5-carboxylate reductase 1 (PYCR1) polynucleotide having SEQ ID NO: 1 in mammalian cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 12 to 26 nucleotides in length wherein said at least one oligonucleotide has at least 90% sequence identity to a reverse complement of a polynucleotide comprising 12 to 26 consecutive nucleotides within nucleotides 1 to 380 of SEQ ID NO: 2; thereby upregulating a function of and/or the expression of the Pyrroline-5-carboxylate reductase 1 (PYCR1) polynucleotide in said cells or tissues in vivo or in vitro.