Patent ID: 8969330
Filing Date: 2015-03-03
Classification: A61P,C07C,C07J,Y10S

Abstract:
1. A process for preparing a compound of formula I: or a pharmaceutically acceptable salt or amino acid conjugate thereof, comprising: a) reacting 3α-hydroxy-7-keto-5β-cholan-24-oic acid with 3,4-dihydropyrane to prepare 3α-tetrahydropyranyloxy-7-keto-5β-cholan-24-oic acid; b) reacting 3α-tetrahydropyranyloxy-7-keto-5β-cholan-24-oic acid with an alkyl bromide of the formula R—Br, wherein R is ethyl, to prepare a compound of formula II: c) reacting the compound of formula II with sodium borohydride to prepare a compound of formula III: d) reacting the compound of formula II with sodium hydroxide to prepare the compound of formula I.