Patent ID: 6242459
Filing Date: 2001-06-05
Classification: A61K,A61P,C07D

Abstract:
A method of treating a CCR5-mediated disease state in mammals which comprises administering to a mammal in need of such treatment, an effective amount of a compound of formula (IA) or a pharmaceutically acceptable salt thereof: ##STR25##wherein:X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are independently one or more of H, OR', or halo;R' is H or optionally substituted C.sub.1-6 alkyl;R.sub.1 is H, C.sub.1-6 alkyl, or one of R.sub.1 is --CO(CF.sub.3);n is 1 or 2; andR is H or C.sub.1-6 alkyl,provided that when R.sub.1 are both H, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are not all hydrogen; and provided that when n is 1, R.sub.1 are both H, and X.sub.2 and X.sub.3 are each hydrogen, X.sub.1 and X.sub.4 are not each 4-ethyl, 3-methoxy, 4-butoxy; and, provided that when n is 1, and R.sub.1 are both H, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are not 2-methoxy-6-chloro; and, provided that when n is 2, and R.sub.1 are both H, X.sub.1, X.sub.2, X.sub.3, and X.sub.4 are not 2-methoxy-6-chloro or 2-fluoro-6-chloro.