Patent ID: 6780998
Filing Date: 2004-08-24
Classification: A61K,A61Q,C07C,C07D

Abstract:
A substituted 2-aminoalkyl-1,4-diaminobenzene compound of the formula (I): wherein R1, R2, R3 and R4, independently of each other, are each hydrogen, a C1- to C6-alkyl group, a C1- to C4-hydroxyalkyl group, a C2- to C4-dihydroxyalkyl group or a C1- to C4-alkoxy-(C1- to C2-)alkyl group, or R1 and R2 together with N form a four member to eight member aliphatic ring; and wherein at least two of said R1, R2, R3 and R4 represent hydrogen and wherein R3 and R4 are not both simultaneously a C1- to C6-alkyl group; R5 represents hydrogen, a halogen atom, a C1- to C4-alkyl group, a C1- to C4-hydroxyalkyl group or a C1- to C4-alkoxy group; R6 and R7, independently of each other, each represent hydrogen, a C1- to C2-alkoxy group, a C1- to C6-alkyl group, a C1- to C6-alkenyl group, a C1- to C4-hydroxyalkyl group, a C3- to C4-dihydroxyalkyl group, a C1- to C4-aminoalkyl group, a C1- to C4-dimethylaminoalkyl group, a C1- to C4-acetylamino-alkyl group, a C1- to C4-methoxyalkyl group, a C1- to C4-ethoxyalkyl group, a C1- to C4-cyanoalkyl group, a C1- to C4-carboxyalkyl group, a C1- to C4-aminocarbonylalkyl group, a pyridylmethyl group, a furfuryl group, a hydrogenated furfuryl group, a substituted pyridyl group, a group of the formula II: a group of the formula III: a group of the formula IV: wherein at least one of R6 and R7 is not hydrogen or R6 and R7 together with N form one of the following rings: R8 represents hydrogen or a C1- to C6-alkyl group; R9 represents hydrogen, a carboxy group or an aminocarbonyl group; R10 and R11, independently of each other, each represent hydrogen, a hydroxy group, an aminocarbonyl group, a methylthiomethyl group, a substituted phenyl group having a phenyl group substituent or a hydroxy group substitutent or a group of the formula: wherein R12, R13, R14, R15 and R16 are each, independently of each other, hydrogen, a halogen atom, a cyano group, a hydroxy group, a C1- to C4-alkoxy group, a C1- to C4-hydroxyalkoxy group, a C1- to C6-alkyl group, a C1- to C4-alkylthioether group, a mercapto group, a nitro group, an amino group, an alkylamino group, an alkylamino group, hydroxyalkylamino group, a dialkylamino group, a di(hydroxyalkyl)amino group, a (dihydroxyalkyl)amino group, a (hydroxyalkyl)-alkylamino group, a trifluoromethane group, a â€”C(O)H group, a â€”C(O)CH3 group, a â€”C(O)CF3 group, a â€”Si(CH3)3 group, a C1- to C4-hydroxyalkyl group, a C3- to C4-dihydoxyalkyl group, or two of the groups R12 to R16 next to each other form an â€”Oâ€”CH2â€”Oâ€” bridge; R17 represents a C1- to C4-alkyl group or a C1- to C4-hydroxyalkyl group; R18 represents hydrogen or a C1- to C6-alkyl group; R19 represents one or more hydrogen, hydroxy, carboxy, aminocarbonyl or hydroxymethyl group or groups; and R20 represents hydrogen or a C1- to C6-alkyl group, with the proviso that R1, R2 and R8 are not each hydrogen when (i) R5 is in the 5-position of the aromatic ring and R5 is hydrogen, a C1- to C4-alkyl group or a halogen atom, and when (ii) R6 and R7, independently of each other, are a C1- to C4-alkyl group or a phenyl group; or or a physiologically compatible, water-soluble salt thereof.