Patent ID: 7901911
Filing Date: 2011-03-08
Classification: A61K,C07K,C12N

Abstract:
1. An isolated polynucleotide encoding an IL-6 receptor•IL-6 fusion protein, comprising: (A) a polynucleotide encoding for an IL-6 receptor represented by the amino acid sequence set forth in SEQ ID NO:63 or a partial sequence of IL-6 receptor that binds to IL-6 wherein the partial sequence of IL-6 receptor has an amino terminus at any one of Leu at the 20 (B) a polynucleotide encoding for an IL-6 represented by the amino acid sequence of SEQ ID NO:64, or a partial sequence of IL-6 that binds to the IL-6 receptor of (A) wherein the partial sequence of IL-6 has an amino terminus at any one of Ala at the 28 wherein (A) and (B) are linked via a peptide bond from the carboxy terminus of (A) to the amino terminus of (B), and wherein said fusion protein induces gp130 for signal transmission.