Patent ID: 6147078
Filing Date: 2000-11-14
Classification: C07D

Abstract:
A compound of having the formula ##STR17## or a pharmaceutically acceptable salt thereof, wherein R.sup.3 is--CH.sub.2 OH,--CH.sub.2 OCH.sub.3,--CH.sub.2 SCH.sub.3,--CH.sub.2 SPh,--SCH.sub.3, or--S(O)CH.sub.3 ;W isC.sub.1-7 alkyl, unsubstituted or substituted with one or more of hydroxy,COOH,amino,phenyl,naphthyl,C.sub.3-7 cycloalkyl,CF.sub.3,N(CH.sub.3).sub.2,--C.sub.1-3 alkylphenyl,--C.sub.1-3 alkylnaphthyl , orheteroaryl;A is ##STR18## wherein Y.sup.1 and Y.sup.2 are independently hydrogaen,C.sub.1-4 alkylC.sub.1-4 alkoxy,C.sub.3-7 cycloalkyl,halogen, ortrifluoromethyl;R.sup.4 isa) hydrogen,b) C.sub.1-4 alkyl,c) C.sub.1-4 alkoxy,d) halogen,e) --OCH.sub.2 CF.sub.3,f) --OCH.sub.2)CN,g) --COOH,h) --OH,i) --COOR.sup.6, where R.sup.6 is C.sub.1-4 alkyl,j) --CONR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are independentlyhydrogen or C.sub.1-4 alkyl,k) --(CH.sub.2).sub.1-4 OH,l) --CH.sub.2 NHC(O)CH.sub.3,m) --CH.sub.2 NHC(O)CF.sub.3,n) --CH.sub.2 NHSO.sub.2 CH.sub.3,o) --SO.sub.2 NH.sub.2,p) --(CH.sub.2).sub.1-4 SO.sub.2 NR.sup.7 R.sup.8,q) --(CH.sub.2).sub.1-4 SO.sub.2 R.sup.6,r) --ZCH.sub.2 CO.sub.2 H,s) --ZCH.sub.2 CO.sub.2 CH.sub.3,t) --ZCH.sub.2 R.sup.14,u) --ZCH.sub.2 CO.sub.2 (CH.sub.2).sub.1-3 CH.sub.3,v) --Z(CHR.sup.9).sub.1-3 C(O)NR.sup.10 R.sup.11,whereinR.sup.9 is H or C.sub.1-4 alkyl,R.sup.10 and R.sup.11 are independentlyi) hydrogen,ii) C.sub.3-7 cycloalkyl,iii) aryl,iv) heteroaryl,v) --(CH.sub.2).sub.1-2 NCH.sub.2 CH.sub.3,vi) C.sub.1-4 alkyl unsubstituted or substituted with one or more of:hydroxy,COOH,amino,aryl, orheteroaryl, orR.sup.10 and R.sup.11 are joined to form a four to seven membered cycloalkyl ring unsubstituted or substituted with hydroxy, amino or aryl,wherein Z is O, S or CH.sub.2, andR.sup.5 ishydrogen,halogen,C.sub.1-4 alkyl,C.sub.1-4 alkoxy,CF.sub.3,CN, orCO.sub.2 NH.sub.2.