Patent ID: 6121475
Filing Date: 2000-09-19
Classification: C07F

Abstract:
In a process for preparing an optically active .beta.-hydroxyester derivative having the formula (1): ##STR8## wherein R.sup.13 stands for an alkenyl group, an alkadienyl group, an alkynyl group, an aryl group, or a group represented by --CH.sub.2 R.sup.14 in which R.sup.14 is an alkyl group, an alkenyl group, an alkadienyl group, an alkynyl group, an aryl group, an aralkyl group, an alkoxyalkyl group or an aryloxyalkyl group, in which any of R.sup.13 and .sup.14 may have one or more substituent groups, and each of R.sup.15, R.sup.16, R.sup.18, R.sup.19 and R.sup.20 independently stands for a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an alkoxyalkyl group, an aryloxy group, or an aryloxyalkyl group; and R.sup.17 stands for an alkyl group, an aryl group, or aralkyl group; provided that two groups selected from the group consisting of R.sup.15 R.sup.16 and R.sup.17 may form a ring in conjunction with the adjacent atom or atoms,by enantioselective aldol addition reaction between an aldehyde having the formula (2) and a ketene silylacetal having the formula (3): ##STR9## wherein each of R.sup.13, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19 and R.sup.20 has the same meaning as above,the improvement which comprises performing the enantioselective aldol addition reaction in the presence of an organic base and a platinum-containing catalyst comprising an optically active bisphosphine-platinum complex having two P--Pt bondings which are equivalent to each other.